Miracle-dz/UniFAR-FTUs huggingface dataset:
The Value of Flexibility in the Italian Water Service Sector: A Real Option Analysis

We analyze the optimal investment strategy of a monopolist which has subscribed a concession contract to provide a public utility, i.e. water service. We present a strategic model in which a monopolist chooses both the timing of the investment and the capacity. We focus not only on the value of the immediate investment, but rather on the value of the investment opportunity. We then extend the model to two interdependent projects, where investing in the first project provides the opportunity to acquire the benefits of the new investment by making a new outlay. We show that flexibility to defer an investment may generate, ceteris paribus, additional profits which may induce positive effects in terms of policy and consumers surplus.
Why Do Non-Investment Grade Rated Companies Issue Convertible Bonds Instead of Bonds in Norway?

I find non-investment graded companies motives for issuing convertible bonds in the Norwegian market by evaluating logistic regression results from a two-step security choice model from samples of 28 convertible bond-, 102 bond- and 229 equity issuances from 2005 to 2011. The findings indicate that companies in the Norwegian market substitute convertibles for bonds if they have valuable investment opportunities at hand and are associated with risk and uncertainty. This paper argues that the issuers of convertible bonds substitute convertibles for bonds to mitigate the asset substitution problem and mitigate debt-related financing costs under the asymmetric information theory. I further deduce that convertibles are used as a debt-instrument in the Norwegian market, different from the US market and more similar to the Western European market. Finding the issuers motives for issuing convertibles in Norway extend current academic research, and can be a fundament for investors when evaluating different convertible bond investment opportunities.
Significance of a common single nucleotide polymorphism in exon 10 of the follicle-stimulating hormone (FSH) receptor gene for the ovarian response to FSH: a pharmacogenetic approach to controlled ovarian hyperstimulation

The p.N680S sequence variation of the follicle-stimulating hormone (FSH) receptor gene was previously shown to influence the ovarian response to FSH in normo-ovulatory women undergoing controlled ovarian hyperstimulation. In this prospective, randomized, controlled study, we tested whether the same daily dose of FSH results in lower levels of oestradiol in women homozygous for the p.N680S sequence variation, and whether the difference can be overcome by higher FSH doses. Women undergoing controlled ovarian hyperstimulation for in vitro fertilization or intracytoplasmic sperm injection and homozygous for the wild-type or for the p.N680S FSH receptor were randomly assigned to group I (Ser/Ser, n=24), receiving an FSH dose of 150 U/day, or group II (Ser/Ser, n=25), receiving an FSH dose of 225 U/day. In group III (Asn/Asn, n=44), the FSH dose was 150 U/day. Age and basal FSH levels were not different between groups. At ovulation induction, total FSH doses were comparable in group I (1631±96 U) and group III (1640±57 U) but significantly higher in group II (2421±112 U) (P<0.001). Peak oestradiol levels on the day of human chorionic gonadotrophin (hCG) administration were significantly lower in group I (5680±675 pmol/l) compared to group III (8679±804 pmol/l) (P=0.028). Increasing the FSH dose from 150 to 225 U/day overcame the lower oestradiol response in women with Ser/Ser (group II, 7804±983 pmol/l). In women undergoing controlled ovarian hyperstimulation, the p.N680S sequence variation results in lower oestradiol levels following FSH stimulation. This lower FSH receptor sensitivity can be overcome by higher FSH doses.
The Cross-Sectional Risk Premium of Decomposed Market Volatility in UK Stock Market

We decompose UK market volatility into short- and long-run components using EGARCH component model and examine the cross-sectional prices of the two components. Our empirical results suggest that these two components are significantly priced in the cross-section and the negative risk premia are consistent with the existing literature. The Fama-French three-factor model is improved by the inclusion of the two volatility components. However, our ICAPM model using market excess return and the decomposed volatility components as state variables compares inferiorly to the traditional three-factor model.
Point-of-Care Platelet Function Testing

Cardiopulmonary bypass has unpredictably deleterious effects on platelet function. Patients with cardiovascular disease have treatments aimed at reducing platelet aggregation and are at risk of excessive bleeding during surgery. Transfusion of blood products, particularly platelets, probably causes increased morbidity and mortality. Conversely, patients with excessive platelet aggregation are at risk of thrombotic complications—undesirable outcomes in the context of myocardial revascularization and prevention of stroke. Platelet function is difficult to monitor. Laboratory tests take time, and the results are not immediately available. Point-of-care (POC) testing of platelet function should facilitate the clinical management of bleeding patients by rationalizing platelet transfusion and avoiding unnecessary transfusion. Furthermore, POC platelet function could alert the clinician to risks of excessive platelet activation and measure the efficacy of antiplatelet therapy. This article outlines some of the POC platelet function monitors available as well as their potential applications.
Host preference and host colonization of the Asian long-horned beetle, Anoplophora glabripennis (Coleoptera Cerambycidae), in Southern Europe

Abstract The Asian long-horned beetle (ALB), Anoplophora glabripennis (Motschulsky), is a highly polyphagous invasive pest with a broad range of host species, but showing relevant differences between infestation areas. Host preference and host colonization (female fecundity, egg and larval survival) were assessed in a population in Northern Italy by choice and no-choice experiments conducted in both field and laboratory conditions. During 5 years of field observations, ALB was found to infest seven genera of trees: Acer, Aesculus, Betula, Populus, Prunus, Salix and Ulmus. However, Acer, Betula, Ulmus and Salix resulted to be the preferred hosts corresponding to 97.5% (1112) of the 1140 infested trees. In both laboratory and field trials carried out on these four host genera, no-choice experiments recorded the highest host colonization of A. glabripennis on Acer trees, with the highest number of laid eggs and the lowest egg and larval mortality. Ulmus and Salix showed a lower number of laid eggs during laboratory choice test, but egg and larval mortality had mean values similar to Acer. On the contrary, despite the high number of Betula trees felled during the eradication plan carried out in the infestation area, this tree species showed the lowest beetle suitability in terms of number of laid eggs and insect survival. An overestimation of the number of infested Betula occurring during the tree survey may explain the discordance between high number of infested Betula and low beetle suitability. Instead, the large number of infested Acer recorded in the field was probably due to the high abundance of these trees occurring in parks and gardens within the infestation area and to the low adult dispersal of A. glabripennis. Overall, results from this study confirm that host species affects both beetle colonization and breeding performance. The study shows ALB host preference and host suitability varying between tree species, suggesting an ALB acceptance even of sub-optimal hosts.
A Fully-Analog Lock-In Amplifier With Automatic Phase Alignment for Accurate Measurements of ppb Gas Concentrations

A novel fully-analog lock-in amplifier for the accurate measurements of low quantities of gas in sensor applications is here presented. When compared with commercial lock-in and other solutions available in the literature, the proposed system implements an automatic alignment of the relative phase between input and reference signals, both at power-on and for any variation of the input signal phase and amplitude during the working time, so allowing to detect, accurately and in a continuous way, the mean value of the input signal coming from sensors (typically buried into noise). The circuit has been optimized to operate at a specified reference frequency, in particular 77 Hz; this value is suitable for gas sensor applications, since it avoids also any kind of interferences at 50 Hz net frequency and its harmonics. Experimental results have confirmed the correct functionality of the system, also tested for both carbon monoxide (CO) and ethylene glycol detections. With respect to the simpler resistive gas sensor interface, implemented by a resistive voltage divider, the improvement experimentally given by the proposed automatic lock-in amplifier, in terms of resolution, has been of a factor of about 100 for the CO and 230 for the ethylene glycol measurements, so allowing a theoretical gas detection in the order of ppb.
Sparse + smooth decomposition models for multi-temporal SAR images

SAR images have distinctive characteristics compared to optical images: speckle phenomenon produces strong fluctuations, and strong scatterers have radar signatures several orders of magnitude larger than others. We propose to use an image decomposition approach to account for these peculiarities. Several methods have been proposed in the field of image processing to decompose an image into components of different nature, such as a geometrical part and a textural part. They are generally stated as an energy minimization problem where specific penalty terms are applied to each component of the sought decomposition. We decompose temporal series of SAR images into three components: speckle, strong scatterers and background. Our decomposition method is based on a discrete optimization technique by graph-cut. We apply it to change detection tasks.
Role of farm-level diversification in the adoption of modern technology in Brazil

The success of modern technology in increasing yields on high-potential lands has been so great that researchers and policymakers alike have been quick to use modern inputs on marginal lands as well. But the results of applying Green Revolution technologies to marginal lands have often been disappointing. What changes in policy and technologies are necessary for use of modern technology to increase the productivity of these marginal lands effectively and sustainably? Research indicates that farms that had substantial yield increases were those that specialized in a few farm products, usually in the products where technological advances were most pronounced. Roles of Farm-Level Diversification in the Adoption of Modern Technology in Brazil, Research Report 104, by Marc Nerlove, Stephen Vosti, and Wesley Basel, focuses on the links between technology adoption and farmers' decisions on product mix and output diversification on what crops or livestock to produce and in what proportions. The report asks the following questions: Does the production of certain types or combinations of products promote or inhibit the use of modern technology? Does concentration on particular products reduce or increase modern input use? Are farmers who have radically altered their product mix more likely to use modern technology intensively?
Logistics and Supply Chain in Malaysia: Issues and Challenges

Rather than being viewed as a supportive industry to other functional areas previously, now, logistics has been regarded as a strategic industry on its own. In the Asia Pacific region, the potential for growth is very promising. Despite of the remarkable expansion of the industry; particularly in Malaysia, there has been very little published research in the area of logistics and supply chain resulting in a very limited dissemination of information for the purpose of coordination, learning, advancement and etc. Thus, the purpose of this paper is to examine the issues and challenges faced by the practitioners as well as the relevant parties involved in the industry. By reviewing the logistics and supply chain management literature in Malaysia followed by a preliminary interviews with five organisations from different sectors, this study found four key issues and problems, namely the operational logistics, service response logistics, information flow, and policy-related issues. These issues have been the hindrance for logistics effectiveness in Malaysia. This paper attempts to open up various issues surrounding this complex and fragmented industry. It thus, provided a base for future researchers to examine any aspects of logistics and supply chain management in Malaysia.
Technical Report and Preliminary Clinical Data of a Novel Catheter for Luminal Re-Entry After Subintimal Dissection

Rationale and Objectives:The objective of this study was to evaluate the safety and the effectiveness of the Outback catheter for intraluminal re-entry after subintimal dissection in the crossing of chronic arterial occlusions. Methods:This study was a proof-of-concept feasibility. Ten patients with totally occluded arteries in the iliac artery to the distal femoral artery (mean occlusion length, 13.1 cm; range, 5–25 cm) were treated with the novel catheter. After successful re-entry, PTA or PTA plus stenting was performed. Results:No perforations, dissections, lacerations, or device complications occurred. The procedural re-entry success rate with the Outback catheter was 50% (5/10 patients). Conclusions:Although the Outback catheter is safe, the percentage of intraluminal reaccess should be ameliorated through engineering improvements because there is some evidence to suggest that subintimal recanalization could produce improved long-term results.
Why is the Market Share of Adjustable-Rate Mortgages so Low?

Over the past several years, U.S. homebuyers have increasingly favored fixed-rate mortgages over adjustable-rate mortgages (ARMs). Indeed, ARMs have dropped to less than 10 percent of all residential mortgage originations, a near-record low. One might speculate that the decline in the ARM share has been driven by ? one-off? factors relating to the financial crisis. However, a statistical analysis suggests that recent trends can largely be explained by the same factors that have historically shaped mortgage choice? most notably, the term structure of interest rates and its effects on the relative price of different types of mortgages. Supply-side factors, in particular a rise in the share of mortgages eligible to be securitized by the housing government-sponsored enterprises, also play a role in the low current ARM share.
Separase Is Required for Homolog and Sister Disjunction during Drosophila melanogaster Male Meiosis, but Not for Biorientation of Sister Centromeres

Spatially controlled release of sister chromatid cohesion during progression through the meiotic divisions is of paramount importance for error-free chromosome segregation during meiosis. Cohesion is mediated by the cohesin protein complex and cleavage of one of its subunits by the endoprotease separase removes cohesin first from chromosome arms during exit from meiosis I and later from the pericentromeric region during exit from meiosis II. At the onset of the meiotic divisions, cohesin has also been proposed to be present within the centromeric region for the unification of sister centromeres into a single functional entity, allowing bipolar orientation of paired homologs within the meiosis I spindle. Separase-mediated removal of centromeric cohesin during exit from meiosis I might explain sister centromere individualization which is essential for subsequent biorientation of sister centromeres during meiosis II. To characterize a potential involvement of separase in sister centromere individualization before meiosis II, we have studied meiosis in Drosophila melanogaster males where homologs are not paired in the canonical manner. Meiosis does not include meiotic recombination and synaptonemal complex formation in these males. Instead, an alternative homolog conjunction system keeps homologous chromosomes in pairs. Using independent strategies for spermatocyte-specific depletion of separase complex subunits in combination with time-lapse imaging, we demonstrate that separase is required for the inactivation of this alternative conjunction at anaphase I onset. Mutations that abolish alternative homolog conjunction therefore result in random segregation of univalents during meiosis I also after separase depletion. Interestingly, these univalents become bioriented during meiosis II, suggesting that sister centromere individualization before meiosis II does not require separase.
Endoscopic transsphenoidal surgery for acromegaly: remission using modern criteria, complications, and predictors of outcome.

CONTEXT Despite the growing application of endoscopic transsphenoidal surgery (ETSS), outcomes for GH adenomas are not clearly defined. OBJECTIVE We reviewed our experience with ETSS with specific interest in remission rates using the 2010 consensus criteria, predictors of remission, and associated complications. DESIGN AND SETTING This was a retrospective single institution study. PATIENTS, INTERVENTIONS, AND OUTCOME MEASURES: Sixty acromegalic patients who underwent ETSS were identified. Remission was defined as a normal IGF-I and either a suppressed GH less than 0.4 ng/ml during an oral glucose tolerance test or a random GH less than 1.0 ng/ml. RESULTS Remission was achieved in all 14 microadenomas and 28 of 46 macroadenomas (61%). Tumor size, age, gender, and history of prior surgery were not predictive on multivariant analysis. In hospital postoperative morning GH levels less than 2.5 ng/ml provided the best prediction of remission (P < 0.001). Preoperative variables predictive of remission included Knosp score (P = 0.017), IGF-I (P = 0.030), and GH (P = 0.042) levels. New endocrinopathy consisted of diabetes insipidus in 5%, adrenal insufficiency in 5.4%, and new hypogonadism in 29% of men and 17% of women. However, 41% of hypogonadal men had normal postoperative testosterone levels and 83% of amenorrheic women regained menses. The most common complaints after surgery were sinonasal (36 of 60, 60%) resolving in all but two. CONCLUSIONS ETSS for GH adenomas is associated with high rates of remission and a low incidence of new endocrinopathy. Despite the panoramic views offered by the endoscope, invasive tumors continue to have lower rates of remission.
Bistatic ISAR image reconstruction using sparse-recovery interpolation of missing data

When a bistatic inverse synthetic aperture radar (ISAR) system fails to collect complete radar cross section (RCS) datasets, bistatic ISAR (Bi-ISAR) images are usually corrupted using the conventional Fourier transform (FT)-based imaging algorithm. To overcome this problem, this paper proposes a new Bi-ISAR image reconstruction method that includes three steps: suboptimal estimation of parameters regarding the bistatic angle in the Bi-ISAR signal model via an orthogonal matching pursuit-type group-searching scheme, Bi-ISAR signal reconstruction using the estimated parameters, and Bi-ISAR image generation using the FT-based imaging algorithm applied to the reconstructed Bi-ISAR signal. To validate the reconstruction capability of the proposed method, bistatic-scattered field data using the physical optics technique as well as the point-scatterer model are used for Bi-ISAR image reconstruction. The results show that the proposed sparse-recovery-interpolation approach based on the Bi-ISAR signal model reconstruction combined with the classical FT-based algorithm can yield high reconstruction accuracy for incomplete bistatic RCS data compared to conventional numerical interpolation methods and existing direct sparse reconstruction techniques.
Cloning and characterization of the RNase P RNA genes from tow porcine mycoplasmas

We report the cloning of the RNase P RNA genes from the primary aetiological agent of porcine pneumonia, Mycoplasma hyopneumoniae, and the closely related commensal, Mycoplasma flocculare. The monocistronic genes each have promoters with AT‐rich ‐35 regions and Rho‐independent‐like transcription terminators which are retained in the RNase P RNA. Both of these RNase P RNA variants are shown to be catalytically active in vitro in spite of a low overall GC content (30%). Our results suggest a new example of a stable mini‐helix in the conserved core of the mycoplasmal RNase P RNAs. Deletion of the corresponding structural element in Escherichia coli RNase P RNA (M1 RNA) generated an RNase P RNA with an impaired substrate interaction. Displacement of this structural element with the mycoplasmal mini‐helix resulted in an enzyme with a phenotype similar to that of wild‐type M1 RNA. in addition, this structural element is important for lead ion‐induced cleavage at specific sites in M1 RNA.
Merging information in speech recognition: Feedback is never necessary

Top-down feedback does not benefit speech recognition; on the contrary, it can hinder it. No experimental data imply that feedback loops are required for speech recognition. Feedback is accordingly unnecessary and spoken word recognition is modular. To defend this thesis, we analyse lexical involvement in phonemic decision making. TRACE (McClelland & Elman 1986), a model with feedback from the lexicon to prelexical processes, is unable to account for all the available data on phonemic decision making. The modular Race model (Cutler & Norris 1979) is likewise challenged by some recent results, however. We therefore present a new modular model of phonemic decision making, the Merge model. In Merge, information flows from prelexical processes to the lexicon without feedback. Because phonemic decisions are based on the merging of prelexical and lexical information, Merge correctly predicts lexical involvement in phonemic decisions in both words and nonwords. Computer simulations show how Merge is able to account for the data through a process of competition between lexical hypotheses. We discuss the issue of feedback in other areas of language processing and conclude that modular models are particularly well suited to the problems and constraints of speech recognition.
VSOC - A Virtual Security Operating Center

Security in virtualised environments is becoming increasingly important for institutions, not only for a firm's own on-site servers and network but also for data and sites that are hosted in the cloud. Today, security is either handled globally by the cloud provider, or each customer needs to invest in its own security infrastructure. This paper proposes a Virtual Security Operation Center (VSOC) that allows to collect, analyse and visualize security related data from multiple sources. For instance, a user can forward log data from its firewalls, applications and routers in order to check for anomalies and other suspicious activities. The security analytics provided by the VSOC are comparable to those of commercial security incident and event management (SIEM) solutions, but are deployed as a cloud-based solution with the additional benefit of using big data processing tools to handle large volumes of data. This allows us to detect more complex attacks that cannot be detected with todays signature-based (i.e. rules) SIEM solutions.