Miracle-dz/UniFAR-FTUs huggingface dataset:
Generating single and multiple cooperative heuristics for the one dimensional bin packing problem using a single node genetic programming island model

Novel deterministic heuristics are generated using Single Node Genetic Programming for application to the One Dimensional Bin Packing Problem. First a single deterministic heuristic was evolved that minimised the total number of bins used when applied to a set of 685 training instances. Following this, a set of heuristics were evolved using a form of cooperative co-evolution that collectively minimise the number of bins used across the same set of problems. Results on an unseen test set comprising a further 685 problem instances show that the single evolved heuristic outperforms existing deterministic heuristics described in the literature. The collection of heuristics evolved by cooperative co-evolution outperforms any of the single heuristics, including the newly generated ones.
Phase noise characterization of oscillators through Ito calculus

Recent phase noise analysis techniques of oscillators mainly rely on solving a stochastic differential equation governing the phase noise process. This equation has been solved in the literature using a number of mathematical tools from probability theory like deriving the Fokker–Planck equation governing the phase noise probability density function. Here, a completely different approach for solving this equation in presence of white noise sources is introduced that is based on the Ito calculus for stochastic differential equations. Time‐domain analytical expressions for the correlation of the noisy variables of the oscillator are derived that in asymptotically large times give the steady‐state stochastic correlations as well as the power spectral densities of the variables. The validity of the new approach is verified by comparing its results against extensive Monte‐Carlo simulations. This approach is applied to an oscillator with a dielectric resonator at 4.127 GHz, and a very good agreement between its results with those of the Monte‐Carlo simulations and the previous approaches is observed. Copyright © 2014 John Wiley & Sons, Ltd.
Vascular assessment of wound healing: a clinical review

Although macrovascular screening of patients with chronic wounds, particularly in the lower extremities, is accepted as part of clinical practice guidelines, microvascular investigation is less commonly used for a variety of reasons. This can be an issue because most patients with macrovascular disease also develop concomitant microvascular dysfunction. Part of the reason for less comprehensive microvascular screening has been the lack of suitable imaging techniques that can quantify microvascular dysfunction in connection with non‐healing chronic wounds. This is changing with the introduction of fluorescence microangiography. The objective of this review is to examine macro‐ and microvascular disease, the strengths and limitations of the approaches used and to highlight the importance of microvascular angiography in the context of wound healing.
Zinc Acetate Lozenges May Improve the Recovery Rate of Common Cold Patients: An Individual Patient Data Meta-Analysis

Abstract Background A previous meta-analysis of 3 zinc acetate lozenge trials estimated that colds were on average 40% shorter for the zinc groups. However, the duration of colds is a time outcome, and survival analysis may be a more informative approach. The objective of this individual patient data (IPD) meta-analysis was to estimate the effect of zinc acetate lozenges on the rate of recovery from colds. Methods We analyzed IPD for 3 randomized placebo-controlled trials in which 80–92 mg/day of elemental zinc were administered as zinc acetate lozenges to 199 common cold patients. We used mixed-effects Cox regression to estimate the effect of zinc. Results Patients administered zinc lozenges recovered faster by rate ratio 3.1 (95% confidence interval, 2.1–4.7). The effect was not modified by age, sex, race, allergy, smoking, or baseline common cold severity. On the 5th day, 70% of the zinc patients had recovered compared with 27% of the placebo patients. Accordingly, 2.6 times more patients were cured in the zinc group. The difference also corresponds to the number needed to treat of 2.3 on the 5th day. None of the studies observed serious adverse effects of zinc. Conclusions The 3-fold increase in the rate of recovery from the common cold is a clinically important effect. The optimal formulation of zinc lozenges and an ideal frequency of their administration should be examined. Given the evidence of efficacy, common cold patients may be instructed to try zinc acetate lozenges within 24 hours of onset of symptoms.
Simultaneous dual-isotope solid-state detector SPECT for improved tracking of white blood cells in suspected endocarditis

Aims High-energy resolution and sensitivity of novel cadmium-zinc-telluride (CZT) detector equipped SPECT systems facilitate simultaneous imaging of multiple isotopes and may enhance the detection of molecular/cellular signals. This may refine the detection of endocarditis. This study was designed to determine the feasibility and diagnostic accuracy of simultaneous imaging of inflammation with 111In-labeled white blood cells (WBCs) and myocardial perfusion with 99mTc-sestamibi, for localization of WBCs relative to the valve plane in suspected endocarditis. Methods and results A dedicated cardiac CZT camera (Discovery 530c, GE Healthcare) was employed. Anthropomorphic thorax phantom studies were followed by clinical studies in 34 patients with suspected infection of native valves (n = 12) or implants (n = 22). Simultaneous 111In-WBC/99mTc perfusion imaging was performed, and compared with standard 111In-WBC planar scintigraphy and SPECT-CT. Phantom studies ruled out significant radioisotope crosstalk. Downscatter on 99mTc images was not observed for 111In activity as high as 2.5*99mTc activity. In patients, image quality was superior for CZT imaging vs. conventional SPECT-CT and planar scintigraphy (P < 0.01). Cadmium-zinc-telluride dual isotope imaging improved reader confidence for detection of inflammatory foci. Diagnostic accuracy based on surgery or Duke Criteria during follow-up was highest for CZT imaging (P < 0.001). Conclusion Novel CZT SPECT technology improves the accuracy of molecular/cellular cardiac imaging. Simultaneous multi-isotope imaging with 111In and 99mTc is feasible and aids in the workup of suspected endocarditis.
The Lane hash function

We propose the cryptographic hash function Lane as a candidate for the SHA-3 competition organised by NIST. Lane is an iterated hash function supporting multiple digest sizes. Components of the AES block cipher are reused as building blocks. Lane aims to be secure, easy to understand, elegant and flexible in implementation.
Coherent dependence clusters

Large clusters of mutual dependence can cause problems for comprehension, testing and maintenance. This paper introduces the concept of coherent dependence clusters, techniques for their efficient identification, visualizations to better understand them, empirical results concerning their practical significance. As the paper will show, coherent dependence clusters facilitate a fine grained analysis of the subtle relationships between clusters of dependence.
Limited sinking of Phaeocystis during a 12 days sediment trap study

There is a controversy discussion about the contribution of the genus Phaeocystis to the vertical carbon export with evidence for and against sedimentation of Phaeocystis. So far, the presence of Phaeocystis in sinking matter was investigated with methods depending on morphological features (microscopy) and fast degradable substances (biochemical analyses). In this study, we determine the occurrence and abundance of Phaeocystis antarctica in short‐term sediment traps and the overlying water column during a 12‐day time period in the Atlantic sector of the Southern Ocean with 454‐pyrosequencing and microscopy counting. In the sediment trap samples, we only found few sequences belonging to Phaeocystis, which was not reflecting the situation in the water column above. The cell counts showed the same results. We conclude that Phaeocystis cells are not generally transported downwards by active sinking or other sinking processes.
Social Role-Aware Emotion Contagion in Image Social Networks

Psychological theories suggest that emotion represents the state of mind and instinctive responses of one’s cognitive system (Cannon 1927). Emotions are a complex state of feeling that results in physical and psychological changes that influence our behavior. In this paper, we study an interesting problem of emotion contagion in social networks. In particular, by employing an image social network (Flickr) as the basis of our study, we try to unveil how users’ emotional statuses influence each other and how users’ positions in the social network affect their influential strength on emotion. We develop a probabilistic framework to formalize the problem into a role-aware contagion model. The model is able to predict users’ emotional statuses based on their historical emotional statuses and social structures. Experiments on a large Flickr dataset show that the proposed model significantly outperforms (+31% in terms of F1-score) several alternative methods in predicting users’ emotional status. We also discover several intriguing phenomena. For example, the probability that a user feels happy is roughly linear to the number of friends who are also happy; but taking a closer look, the happiness probability is superlinear to the number of happy friends who act as opinion leaders (Page et al. 1999) in the network and sublinear in the number of happy friends who span structural holes (Burt 2001). This offers a new opportunity to understand the underlying mechanism of emotional contagion in online social networks.
Erythropoietin signaling regulates heme biosynthesis

Heme is required for survival of all cells, and in most eukaryotes, is produced through a series of eight enzymatic reactions. Although heme production is critical for many cellular processes, how it is coupled to cellular differentiation is unknown. Here, using zebrafish, murine, and human models, we show that erythropoietin (EPO) signaling, together with the GATA1 transcriptional target, AKAP10, regulates heme biosynthesis during erythropoiesis at the outer mitochondrial membrane. This integrated pathway culminates with the direct phosphorylation of the crucial heme biosynthetic enzyme, ferrochelatase (FECH) by protein kinase A (PKA). Biochemical, pharmacological, and genetic inhibition of this signaling pathway result in a block in hemoglobin production and concomitant intracellular accumulation of protoporphyrin intermediates. Broadly, our results implicate aberrant PKA signaling in the pathogenesis of hematologic diseases. We propose a unifying model in which the erythroid transcriptional program works in concert with post-translational mechanisms to regulate heme metabolism during normal development. DOI: http://dx.doi. org/10.7554/eLife.24767. 001
Human whole body motion characterization from embedded Kinect

Non-verbal communications such as kinesthetics, or body language and posture are important codes used to establish and maintain interpersonal relationships. They can also be utilized for safe and efficient human robot interactions. A correct interpretation of the human activity through the analysis of certain spatio-temporal and dynamic parameters represent an outstanding benefit for the quality of human machine communication in general. This paper presents an effective markerless motion capture system provided by a mobile robot for sensing human activity, in non-invasive fashion. We present a physical model based method exploiting the embedded Kinect. Its performances are evaluated first comparing the results to those obtained with a precise 3D motion capture marker based system and to data obtained from a dynamic posturography platform. Then an experiment in real life conditions is performed to assess the system sensitivity to some gait disturbances.
A Novel Anti-Spoofing Solution for Iris Recognition Toward Cosmetic Contact Lens Attack Using Spectral ICA Analysis

In this study, we maneuvered a dual-band spectral imaging system to capture an iridal image from a cosmetic-contact-lens-wearing subject. By using the independent component analysis to separate individual spectral primitives, we successfully distinguished the natural iris texture from the cosmetic contact lens (CCL) pattern, and restored the genuine iris patterns from the CCL-polluted image. Based on a database containing 200 test image pairs from 20 CCL-wearing subjects as the proof of concept, the recognition accuracy (False Rejection Rate: FRR) was improved from FRR = 10.52% to FRR = 0.57% with the proposed ICA anti-spoofing scheme.
Eculizumab in secondary atypical haemolytic uraemic syndrome

Background. Complement dysregulation occurs in thrombotic microangiopathies (TMAs) other than primary atypical haemolytic uraemic syndrome (aHUS). A few of these patients have been reported previously to be successfully treated with eculizumab. Methods. We identified 29 patients with so‐called secondary aHUS who had received eculizumab at 11 Spanish nephrology centres. Primary outcome was TMA resolution, defined by a normalization of platelet count (>150 × 109/L) and haemoglobin, disappearance of all the markers of microangiopathic haemolytic anaemia (MAHA), and improvement of renal function, with a ≥25% reduction of serum creatinine from the onset of eculizumab administration. Results. Twenty‐nine patients with secondary aHUS (15 drug‐induced, 8 associated with systemic diseases, 2 with postpartum, 2 with cancer‐related, 1 associated with acute humoral rejection and 1 with intestinal lymphangiectasia) were included in this study. The reason to initiate eculizumab treatment was worsening of renal function and persistence of TMA despite treatment of the TMA cause and plasmapheresis. All patients showed severe MAHA and renal function impairment (14 requiring dialysis) prior to eculizumab treatment and 11 presented severe extrarenal manifestations. A rapid resolution of the TMA was observed in 20 patients (68%), 15 of them showing a ≥50% serum creatinine reduction at the last follow‐up. Comprehensive genetic and molecular studies in 22 patients identified complement pathogenic variants in only 2 patients. With these two exceptions, eculizumab was discontinued, after a median of 8 weeks of treatment, without the occurrence of aHUS relapses. Conclusion. Short treatment with eculizumab can result in a rapid improvement of patients with secondary aHUS in whom TMA has persisted and renal function worsened despite treatment of the TMA‐inducing condition.
Compressive Sensing : Single Pixel SWIR Imaging of Natural Scenes

Photos captured in the shortwave infrared (SWIR) spectrum are interesting in military applications because they are independent of what time of day the picture is captured because the sun, moon, stars and night glow illuminate the earth with short-wave infrared radiation constantly. A major problem with today’s SWIR cameras is that they are very expensive to produce and hence not broadly available either within the military or to civilians. Using a relatively new technology called compressive sensing (CS), enables a new type of camera with only a single pixel sensor in the sensor (a SPC). This new type of camera only needs a fraction of measurements relative to the number of pixels to be reconstructed and reduces the cost of a short-wave infrared camera with a factor of 20. The camera uses a micromirror array (DMD) to select which mirrors (pixels) to be measured in the scene, thus creating an underdetermined linear equation system that can be solved using the techniques described in CS to reconstruct the image. Given the new technology, it is in the Swedish Defence Research Agency (FOI) interest to evaluate the potential of a single pixel camera. With a SPC architecture developed by FOI, the goal of this thesis was to develop methods for sampling, reconstructing images and evaluating their quality. This thesis shows that structured random matrices and fast transforms have to be used to enable high resolution images and speed up the process of reconstructing images significantly. The evaluation of the images could be done with standard measurements associated with camera evaluation and showed that the camera can reproduce high resolution images with relative high image quality in daylight.
Sleep Duration and Sleep Disturbances as Predictors of Healthy and Chronic Disease–Free Life Expectancy Between Ages 50 and 75: A Pooled Analysis of Three Cohorts

Background The aim of this study was to examine the associations of sleep duration and sleep disturbances with healthy and chronic disease-free life expectancy (LE) between ages 50 and 75. Methods Data were drawn from repeated waves of three occupational cohort studies in England, Finland, and Sweden (n = 55,494) and the follow-up ranged from 6 to 18 years. Self-reported sleep duration was categorized into <7, 7-8.5, and ≥9 hours and sleep disturbances into no, moderate, and severe. Health expectancy was estimated with two health indicators: healthy LE based on years in good self-rated health and chronic disease-free LE based on years without chronic diseases. Multistate life table models were used to estimate healthy and chronic disease-free LE from age 50 to 75 years for each category of sleep measures in each cohort. Fixed-effects meta-analysis was used to pool the cohort-specific results into summary estimates. Results Persons who slept 7-8.5 hours could expect to live 19.1 (95% CI 19.0-19.3) years in good health and 13.5 (95% CI 13.2-13.7) years without chronic diseases between ages 50 and 75. Healthy and disease-free years were 1-3 years shorter for those who slept less than 7 hours or slept 9 hours or more. Persons who did not have sleep disturbances could expect to live 20.4 (95% CI 20.3-20.6) years in good health and 14.3 (95% CI 14.1-14.5) years without chronic diseases between ages 50 and 75. Healthy and disease-free years were 6-3 years shorter for those who reported severe sleep disturbances. Conclusions Sleeping 7-8.5 hours and having no sleep disturbances between ages 50 to 75 are associated with longer healthy and chronic disease-free LE.
Design of high performance two stage CMOS cascode op-amps with stable biasing

The technique of mirror biasing is introduced and applied to a very high gain two stage CMOS cascode op-amp, in order to desensitize its output voltage to bias variations. Various performance metrics like low frequency common mode and power supply rejection ratios, slew rate and the sensitivity of the systematic offset are substantially improved. The improved performance is theoretically predicted and substantiated through circuit simulations.
Relations among birth condition, maternal condition, and postnatal growth in captive common marmoset monkeys (Callithrix jacchus)

The present study characterizes the relations among maternal condition, litter size, birth condition, and growth in body weight for a population of common marmosets. The subjects of the study were marmosets born into a single colony between 1994 and 2001. Three sets of analyses were conducted to answer the following questions: 1) Is there a relationship between litter size, maternal condition, and birth condition? In the study population, maternal body weight, maternal age, litter size, and birth condition were related in a complex fashion. Birth weight and prenatal long‐bone growth, as reflected in knee–heel length, were both related to maternal age, with older mothers supporting higher prenatal growth. Age and maternal condition appeared to interact as determinants of long‐bone growth, as the combination of older and larger mothers resulted in significantly longer knee–heel lengths in their offspring. 2) Is there a relationship between birth condition or maternal condition and subsequent growth or final adult size? The early growth rate in this population was similar to early growth rates reported for three different marmoset colonies, suggesting that early growth may be relatively inflexible in this species. However, within this population, the variation that did occur in early growth rate was related to birth weight and maternal weight. Later growth and adult weight were related to birth weight and litter size: small twin infants displayed slower later growth rates and were smaller as adults than twins that began life at a higher birth weight, while the birth weight of triplets was not related to adult size. In these marmosets, small infants that were the result of increased litter size differed from small infants whose small birth size resulted from other factors. This reinforces the proposal that the causes of low birth weight will be relevant to the development of the marmoset as a model of prenatal environmental effects. Am. J. Primatol. 62:83–94, 2004. © 2004 Wiley‐Liss, Inc.
Adaptively adjusting ECN marking thresholds for datacenter networks

ECN thresholds have limited operational range and very strict scope. Lower thresholds exacerbate the queue underflow while higher thresholds increase the queueing delays. In this paper, an Adaptive ECN (A-ECN) marking scheme is proposed to enhance the performance of ECN. A-ECN can adaptively adjust ECN marking thresholds in different scenarios to achieve good generality. Therefore, network operators can directly deploy A-ECN in various environments regardless of underlying queue types and bandwidth.
Clinical efficacy of liposome-encapsulated Aloe vera on melasma treatment during pregnancy

ABSTRACT Background: Melasma is a challenging dermatological condition during pregnancy. The aim of this study was to determine the clinical efficacy of a topical liposome-encapsulated Aloe vera preparation, on melasma in pregnant women. In order to enhance the bioavailability of Aloe vera leaf gel extract (AGE), liposomes encapsulating Aloe vera were prepared and examined for their biochemical properties. Methods: In this double-blinded, randomized clinical trial, two groups of pregnant women with melasma who were at their second trimester of pregnancy or later were studied. The patients in the experimental group (90) received liposome-encapsulated AGE (in the form of gel), the other 90 patients were placed in the control group (AGE) for 5 weeks. The liposomes were prepared from a soybean lecithin (SLP-WHITE, 1.0 wt 15 %), with a high trapping efficiency for incorporating about 0.5 wt% AGE concentration. The stable liposomes were then prepared from 1.0 wt% of SLP-WHITE, and different concentrations of AGE were prepared by mechanochemical method using a microfluidizer and homogenizer. The liposomes obtained from 0.25 wt% of AGE were confirmed to be small unilamellar vesicles with a diameter < 200 nm, which remained well dispersed for at least 2 weeks. Our results are expressed as mean (±SD), the Melasma Area Severity Index (MASI) score was used to record melasma severity, and analysis of co-variance (ANCOVA) was used for data analysis. Results: After 5 weeks of melasma treatment in pregnant women, there was 32% improvement in the MASI score in the liposomal-AGE treatment group as compared to 10% improvement in the control group. The prevalence of melisma decreases with an increase in parity, i.e. 39 (43.35%), 34 (37.8%), 15 (16.7%) and 2 (2.2%) for the experimental groups, and 45 (50%), 35 (38.9%), 10 (11.1%) and 0 (0%) for the control group (p = 0.32). There was a significant difference between experimental and control groups in terms of mean MASI score after the trial. There was no significant difference between the groups regarding family history of melasma, occupation, frequency of sunscreen usage and hours of sun exposure. However, within each group, there was a slight to great significant difference observed. Conclusion: Liposome-encapsulated Aloe vera gel extract was superior to AGE in decreasing the severity of melasma in pregnancy due to their ease in percolation; it lightens the melasma, with only mild side effects.