Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiac Arrest Cases and Automated External Defibrillator Use in Railroad Stations in Tokyo

Objective: Nationwide dissemination of public-access defibrillation (PAD) contributed to an increase of survival rate in Japan. We analysed cardiac arrests (CAs) that occurred in railroad stations in Tokyo to evaluate PAD in the metropolis. Methods: We collected Utstein data from the Tokyo Fire Department (TFD) and analysed CA cases that occurred in stations. In total, 245 non-traumatic CAs from January 1, 2007 to March 31, 2008 were analysed; CAs in children under 8 years were excluded. Results: The rates of pre-hospital return of spontaneous circulation (ROSC) were 41 out of 145 witnessed CA patients (28.3%) and 12 ROSC out of 100 unwitnessed CA patients (12%). Of 245 CA cases, bystander cardiopulmonary resuscitation (CPR) performed in 156 (63.7%), automated external defibrillator (AED) used in 117 (47.8%) and shock delivered in 65 (26.5%). Rates of ROSC were 31.6% (37/117) with AED use significantly higher than those of 12.5% (16/128) without AED use (P < 0.001). Most CAs occurred on platforms; the use of AEDs on platforms increased from 18/31 (58.1%) in 2007 to 32/43 (74.4%) in 2008 and ROSC rates increased from 8 (25.8%) to 14 (32.6%), respectively. On train CAs: ROSC cases were very few, 1 case each year (8.3%; 7.7%) while the use of AED increased from 8/12 (66.7%) in 2007 to 10/13 (76.9%) in 2008. Conclusion: Bystander CPR and the use of AED at railroad stations improved ROSC for out-of-hospital cardiac arrest (OHCA) patients. AED location and strategies for dealing with CAs on trains should be re-evaluated.
Abusir 3D survey 2015

In 2015, in collaboration with the Czech Institute of Egyptology, we, a Japanese consortium, initiated the Abusir 3D Survey (A-3DS) for the 3D documentation of the site’s pyramids, which have not been updated since the time of the architectural investigations of Vito Maragioglio and Celeste Rinaldi in the 1960s to the 1970s. The first season of our project focused on the exterior of Neferirkare’s pyramid, the largest pyramid at Abusir. By developing a strategic mathematical 3D survey plan, step-by-step 3D documentation to suit specific archaeological needs, and producing a new display method for the 3D data, we successfully measured the dimensions of the pyramid in a cost-effective way. Abusir – Old Kingdom – Fifth Dynasty – Neferirkare – pyramid – 3D survey – SFM/MVS Yukinori Kawae (yukinegy@gmail.com) Research Center for Cultural Heritage and Texts, Graduate School of Letters, Nagoya University Yoshihiro Yasumuro (yasumuro@kansai-u.ac.jp) Faculty of Environmental and Urban Engineering, Kansai University Ichiroh Kanaya (kanaya@pineapple.cc) School of Information Systems, the University of Nagasaki Hiroshige Dan (dan@kansai-u.ac.jp) Faculty of Environmental and Urban Engineering, Kansai University Fumito Chiba (f-chiba@lang-co.jp) LANG CO., LTD ABUS IR 3D SURVEY 2015 P E S X V I I / 2 0 1 6 11 PES XVII_2016_reports_3-35_PES 13.12. 16 11:47 Stránka 11
Conjunctive Queries with Inequalities Under Updates

Modern application domains such as Composite Event Recognition (CER) and real-time Analytics require the ability to dynamically refresh query results under high update rates. Traditional approaches to this problem are based either on the materialization of subresults (to avoid their recomputation) or on the recomputation of subresults (to avoid the space overhead of materialization). Both techniques have recently been shown suboptimal: instead of materializing results and subresults, one can maintain a data structure that supports efficient maintenance under updates and can quickly enumerate the full query output, as well as the changes produced under single updates. Unfortunately, these data structures have been developed only for aggregate-join queries composed of equi-joins, limiting their applicability in domains such as CER where temporal joins are commonplace. In this paper, we present a new approach for dynamically evaluating queries with multi-way θ-joins under updates that is effective in avoiding both materialization and recomputation of results, while supporting a wide range of applications. To do this we generalize Dynamic Yannakakis, an algorithm for dynamically processing acyclic equi-join queries. In tandem, and of independent interest, we generalize the notions of acyclicity and free-connexity to arbitrary θ-joins. We instantiate our framework to the case where θ-joins are only composed of equalities and inequalities ( , ≥) and experimentally compare this algorithm, called IEDyn, to state of the art CER systems as well as incremental view maintenance engines. IEDyn performs consistently better than the competitor systems with up to two orders of magnitude improvements in both time and memory consumption.
Meta-models and Infrastructure for Smalltalk Omnipresent History

Source code management systems record dierent versions of code. Tool support can then compute deltas between versions. However there is little out of the box support to be able to perform queries and analysis over the complete history: for example tools have to build their own infrastructure to identify slices of changes and their dierences since the beginning of the project. We believe that this is due to the lack of a powerful code meta-model as well as an infrastructure. For example, in Smalltalk often several source code meta-models coexist: the Smalltalk reective API coexists with the one of the Refactoring engine or distributed versioning system such as Monticello. While having specic meta-models is an adequate engineered solution, it multiplies meta-models and it requires more maintenance eorts ( e.g., duplication of tests, transformation between models), and more importantly navigation tool reuse when meta-models do not oer polymorphic APIs. As a rst step to solve this problem, this article presents several source code models that could be used to support several activities and proposes an unied and layered approach to be the foundation for building an infrastructure for omnipresent version browsing.
Ten-year outcome of vagus nerve stimulation-implanted patients with treatment-resistant depression: two Italian cases

Over the last 15 years, vagus nerve stimulation (VNS) has been used as an augmentative therapeutic intervention in patients with treatment-resistant depression (TRD), whether with a lifetime diagnosis of major depressive disorder or bipolar disorder. From being a potentially effective treatment in the acute phase of TRD, recently published treatment guidelines seemed to converge on the indication that VNS’s greatest benefit may be seen mostly beyond the short term. However, with the exception of a recent multicenter American report, very few studies have assessed the long-term efficacy of VNS in TRD patients. Herein, we present the cases of two Italian patients with TRD, with 10-year VNS follow-up evaluation. Both patients were found to benefit from augmentative VNS, and the latency of their stimulation response, tolerability, associated pharmacological treatment, number and duration of recurrences, and overall level of functioning are described and discussed. Further reports with larger samples are needed to support the long-term efficacy and tolerability of VNS in TRD patients, particularly beyond 5 years of follow-up.
What's (Not) Validating Network Paths: A Survey

Validating network paths taken by packets is critical for a secure Internet architecture. Any feasible solution must both enforce packet forwarding along endhost-specified paths and verify whether packets have taken those paths. However, neither enforcement nor verification is supported by the current Internet. Due likely to a long-standing confusion between routing and forwarding, only limited solutions for path validation exist in the literature. This survey article aims to reinvigorate research in to the significant and essential topic of path validation. It crystallizes not only how path validation works but also where seemingly qualified solutions fall short. The analyses explore future research directions in path validation toward improving security, privacy, and efficiency.
Advanced Materials and Materials Genome—Review

Metamaterials are composite materials whose material properties (acoustic, electrical, magnetic, or optical, etc.) are determined by their constitutive structural materials, especially the unit cells. The development of metamaterials continues to redefine the boundaries of materials science. In the field of electromagnetic research and beyond, these materials offer excellent design flexibility with their customized properties and their tunability under external stimuli. In this paper, we first provide a literature review of metamaterials with a focus on the technology and its evolution. We then discuss steps in the industrialization process and share our own experience.
Great east Japan earthquake viewed from a URL shortener

On March 11th 2011, a great earthquake and tsunami hit eastern Japan. After that, several web sites, especially those providing helpful disaster-related information, were overloaded due to flash crowds caused by Twitter users. In order to mitigate the flash crowds, we develop a new URL shortener that redirects Twitter users to a CDN instead of original sites, since Twitter users rely on URL shorteners like bit.ly to shorten long URLs. In this paper, we describe our experience of developing and operating the URL shortener in the aftermath of the giant earthquake. Since the flash crowds were a serious problem in an emergency, we had to develop it as quickly as possible with a spirit of so-called agile software development. We then explain our HTTP request log collected at the URL shortener (it is now available online). To investigate the cause of flash crowds, the log is examined with tweets (Twitter messages) provided by another research project; this collaboration is realized by the encouragement of the workshop committee. We hope our experience will be helpful in tackling future disasters.
MAQSA: a system for social analytics on news

We present MAQSA, a system for social analytics on news. MAQSA provides an interactive topic-centric dashboard that summarizes news articles and social activity (e.g., comments and tweets) around them. MAQSA helps editors and publishers in newsrooms understand user engagement and audience sentiment evolution on various topics of interest. It also helps news consumers explore public reaction on articles relevant to a topic and refine their exploration via related entities, topics, articles and tweets. Given a topic, e.g., "Gulf Oil Spill," or "The Arab Spring", MAQSA combines three key dimensions: time, geographic location, and topic to generate a detailed activity dashboard around relevant articles. The dashboard contains an annotated comment timeline and a social graph of comments. It utilizes commenters' locations to build maps of comment sentiment and topics by region of the world. Finally, to facilitate exploration, MAQSA provides listings of related entities, articles, and tweets. It algorithmically processes large collections of articles and tweets, and enables the dynamic specification of topics and dates for exploration. In this demo, participants will be invited to explore the social dynamics around articles on oil spills, the Libyan revolution, and the Arab Spring. In addition, participants will be able to define and explore their own topics dynamically.
Antibody-sandwich ELISA analysis of a novel blood biomarker of CST4 in gastrointestinal cancers

Background Members of the cystatin family have increasingly been proven to be involved in several tumors, including gastric cancer (GC) and colorectal cancer (CRC). Cystatin S (CST4) was found to be upregulated at the gene expression level in GC cells, making it a potential novel biomarker for the early diagnosis of gastrointestinal cancer. Materials and methods Quantitative real-time polymerase chain reaction and Western blotting analysis were used to explore CST4 expression in gastrointestinal cancer tissues and cell lines. We purified CST4 recombinant protein and generated anti-CST4 monoclonal antibodies to develop an antibody-sandwich enzyme-linked immunosorbent assay (ELISA) analysis system for blood CST4 detection. The performance and clinical efficacy of the detection method were evaluated using a training set and validation set, respectively. Results According to the quantitative real-time polymerase chain reaction and Western blotting results, CST4-mRNA expression and protein expression were upregulated in gastrointestinal cancer tissues and cell lines. The ELISA detection system for CST4 showed significantly better sensitivities of 69.0% and 69.0% and specificities of 85.6% and 83.6% for GC and CRC, respectively, than other common clinical biomarkers, carcinoembryonic antigen, CA19-9, CA125, and CA72-4. Clinical verification experiments using GC and CRC validation sets also found distinguishable CST4 median concentrations (177.7 pg·mL−1 and 174.2 pg·mL−1 respectively) and high positive detection rates (72.3% and 88.4% respectively), further confirming the specificity and sensitivity of this method. Conclusion We validated the overexpression of CST4 in gastrointestinal cancer tissues and cell lines and developed an antibody-sandwich ELISA analysis system for blood CST4 detection, which exhibited high specificity and sensitivity. Novel blood biomarkers of CST4 have enormous potential in terms of clinical diagnostic value in GC and CRC.
Aesthetics and Rejuvenation of the Temple

Abstract The temples are an often overlooked, but important element of facial rejuvenation. The anatomy of the temple should be understood prior to any intervention in this location. Multimodal treatment to re-establish youthful convexity, proper hairline position, and correct actinic damage is recommended for optimal results. Important anatomy, aesthetic goals, and methods of rejuvenation are reviewed in detail.
Eye care in young children: a parent survey exploring access and barriers

A questionnaire was designed to investigate the attitudes of parents toward eye care for their young children (4–6‐year‐olds) and possible barriers to accessing eye care for this age group. An exploration was undertaken to determine whether these beliefs and barriers are influenced by certain demographic factors such as ethnicity, level of parental income, level of parental education, confidence with speaking English and a reported family history of eye problems.
STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus

Significance Superenhancers regulate the expression of genes that specify cell type-specific development, but little is known regarding their function and regulation in vivo. Here, we study the cytokines IL-2 and IL-21, which critically control the immune response. These cytokines induce the binding of transcription factors STAT5 and STAT3, respectively, at superenhancers in a cytokine- and gene-specific manner. STAT5-bound superenhancers regulate genes highly induced by IL-2, with STAT5 mediating chromatin looping within such genes, including Il2ra, which mediates responsiveness to IL-2. By deleting three STAT5 binding sites that mediate IL-2–induced chromatin looping at the Il2ra locus, we demonstrate that superenhancer elements cooperatively control gene expression. Overall, we elucidate cytokine-dependent superenhancer function in general and provide detailed analysis of the Il2ra superenhancer. Cytokines critically control immune responses, but how regulatory programs are altered to allow T cells to differentially respond to distinct cytokine stimuli remains poorly understood. Here, we have globally analyzed enhancer elements bound by IL-2–activated STAT5 and IL-21–activated STAT3 in T cells and identified Il2ra as the top-ranked gene regulated by an IL-2–activated STAT5-bound superenhancer and one of the top genes regulated by STAT3-bound superenhancers. Moreover, we found that STAT5 binding was rapidly superenriched at genes highly induced by IL-2 and that IL-2–activated STAT5 binding induces new and augmented chromatin interactions within superenhancer-containing genes. Based on chromatin interaction analysis by paired-end tag (ChIA-PET) sequencing data, we used CRISPR-Cas9 gene editing to target three of the STAT5 binding sites within the Il2ra superenhancer in mice. Each mutation decreased STAT5 binding and altered IL-2–induced Il2ra gene expression, revealing that individual elements within the superenhancer were not functionally redundant and that all were required for normal gene expression. Thus, we demonstrate cooperative utilization of superenhancer elements to optimize gene expression and show that STAT5 mediates IL-2–induced chromatin looping at superenhancers to preferentially regulate highly inducible genes, thereby providing new insights into the mechanisms underlying cytokine-dependent superenhancer function.
Nuclear factor-κB regulates expression of platelet phospholipase C-β2 (PLCB2)

Summary Phospholipase C (PLC)-β2 (gene PLCB2) is a critical regulator of platelet responses upon activation. Mechanisms regulating of PLC-β2 expression in platelets/MKs are unknown. Our studies in a patient with platelet PLC-β2 deficiency revealed the PLCB2 coding sequence to be normal and decreased platelet PLC-β2 mRNA, suggesting a defect in transcriptional regulation. PLCB2 5’- upstream region of the patient revealed a heterozygous 13 bp deletion (-1645/-1633 bp) encompassing a consensus sequence for nuclear factor-κB (NF-κB). This was subsequently detected in three of 50 healthy subjects. To understand the mechanisms regulating PLC-β2, we studied the effect of this variation in the PLCB2. Gel-shift studies using nuclear extracts from human erythroleukaemia (HEL) cells or recombinant p65 showed NF-κB binding to oligonucleotide with NF-κB site; in luciferase reporter studies its deletion reduced PLCB2 promoter activity. PLCB2 expression was decreased by siRNA knockdown of NF-κB p65 subunit and increased by p65 overexpression. By immunoblotting platelet PLC-β2 in 17 healthy subjects correlated with p65 (r=0.76, p=0.0005). These studies provide the first evidence that NF-kB regulates MK/platelet PLC-β2 expression. This interaction is important because of the major role of PLC-β2 in platelet activation and of NF-κB in processes, including inflammation and atherosclerosis, where both are intimately involved. Supplementary Material to this article is available online at www.thrombosis-online.com.
Differences in Abundances of Total Vibrio spp., V. vulnificus, and V. parahaemolyticus in Clams and Oysters in North Carolina

ABSTRACT Filter feeding shellfish can concentrate pathogenic bacteria, including Vibrio vulnificus and Vibrio parahaemolyticus, as much as 100-fold from the overlying water. These shellfish, especially clams and oysters, are often consumed raw, providing a route of entry for concentrated doses of pathogenic bacteria into the human body. The numbers of foodborne infections with these microbes are increasing, and a better understanding of the conditions that might trigger elevated concentrations of these bacteria in seafood is needed. In addition, if bacterial concentrations in water are correlated with those in shellfish, then sampling regimens could be simplified, as water samples can be more rapidly and easily obtained. After sampling of oysters and clams, either simultaneously or separately, for over 2 years, it was concluded that while Vibrio concentrations in oysters and water were related, this was not the case for levels in clams and water. When clams and oysters were collected simultaneously from the same site, the clams were found to have lower Vibrio levels than the oysters. Furthermore, the environmental parameters that were correlated with levels of Vibrio spp. in oysters and water were found to be quite different from those that were correlated with levels of Vibrio spp. in clams. IMPORTANCE This study shows that clams are a potential source of infection in North Carolina, especially for V. parahaemolyticus. These findings also highlight the need for clam-specific environmental research to develop accurate Vibrio abundance models and to broaden the ecological understanding of clam-Vibrio interactions. This is especially relevant as foodborne Vibrio infections from clams are being reported.
I-ATAC: interactive pipeline for the management and pre-processing of ATAC-seq samples

Assay for Transposase Accessible Chromatin (ATAC-seq) is an open chromatin profiling assay that is adapted to interrogate chromatin accessibility from small cell numbers. ATAC-seq surmounted a major technical barrier and enabled epigenome profiling of clinical samples. With this advancement in technology, we are now accumulating ATAC-seq samples from clinical samples at an unprecedented rate. These epigenomic profiles hold the key to uncovering how transcriptional programs are established in diverse human cells and are disrupted by genetic or environmental factors. Thus, the barrier to deriving important clinical insights from clinical epigenomic samples is no longer one of data generation but of data analysis. Specifically, we are still missing easy-to-use software tools that will enable non-computational scientists to analyze their own ATAC-seq samples. To facilitate systematic pre-processing and management of ATAC-seq samples, we developed an interactive, cross-platform, user-friendly and customized desktop application: interactive-ATAC (I-ATAC). I-ATAC integrates command-line data processing tools (FASTQC, Trimmomatic, BWA, Picard, ATAC_BAM_shiftrt_gappedAlign.pl, Bedtools and Macs2) into an easy-to-use platform with user interface to automatically pre-process ATAC-seq samples with parallelized and customizable pipelines. Its performance has been tested using public ATAC-seq datasets in GM12878 and CD4+T cells and a feature-based comparison is performed with some available interactive LIMS (Galaxy, SMITH, SeqBench, Wasp, NG6, openBIS). I-ATAC is designed to empower non-computational scientists to process their own datasets and to break to exclusivity of data analyses to computational scientists. Additionally, I-ATAC is capable of processing WGS and ChIP-seq samples, and can be customized by the user for one-independent or multiple-sequential operations.
Communicative Strategy in a Formal Model of Dispute

We study human-human dialogues in a natural language where the communicative goal of the initiator of dialogue is to bring the partner to a decision to do a certain action. If the partner does not accept the goal then dispute will start. Arguments for and against of doing the action will be presented by the participants and finally, one of them wins and another loses the dispute. We present a formal model of dispute which includes a model of argument. We discuss involvement of the notion of communicative strategy in the model. A communicative strategy is considered as an algorithm used by a participant for achieving his or her communicative goal. A communicative strategy determines also how a participant is moving in âcommunicative spaceâ during interaction. Communicative space is characterized by a number of coordinates (e.g. social distance between participants, intensity of communication, etc.). A limited version of the model of dispute is implemented on the computer.