Miracle-dz/UniFAR-FTUs huggingface dataset:
RESEARCH STUDIES AND PROCEDURES

PROMISING LINES FOR RESEARCH STUDIES ON THE HARDENING OF PAYING ASPHALTS ARE DISCUSSED. PROMISING RECOMMENDATIONS ARE: (1) FURTHER ELUCIDATION OF CHEMICAL MECHANISMS SINCE RECENT ADVANCES IN HIGH MASS SPECTROMETRY, INFRARED SPECTROSCOPY AND CHROMATOGRAPHY COULD BE UTILIZED TO DETERMINE THE SPECIFIC NATURE OF OXIDATION REACTIONS WHICH LEAD TO HARDENING, (2) EFFECT OF ENVIRONMENT ON HARDENING RATE USING MICROFILM TECHNIQUES TO ACCELERATE THE ACCUMULATION OF QUANTITATIVE INFORMATION, AND (3) IMPROVED TECHNIQUES FOR MEASURING 'STIFFNESS' AT LOW TEMPERATURES AND SHORT LOADING TIMES BY DEVELOPMENT OF MEASURING TECHNIQUES OF THE STRESS-STRAIN RELATIONSHIP OF MICRO-SAMPLES OF ASPHALTS IN THE PURELY ELASTIC AND VISCO-ELASTIC REGIONS.
Female Sex Is a Risk Modifier Rather Than a Risk Factor for Stroke in Atrial Fibrillation: Should We Use a CHA2DS2-VA Score Rather Than CHA2DS2-VASc?

Background: Stroke risk in atrial fibrillation is assessed by using the CHA2DS2-VASc score. Sex category (Sc, ie, female sex) confers 1 point on CHA2DS2-VASc. We hypothesized that female sex is a stroke risk modifier, rather than an overall risk factor, when added to a CHA2DS2-VA (sex-independent thromboembolism risk) score scale. Methods: Using 3 nationwide registries, we identified patients with incident nonvalvular atrial fibrillation from January 1, 1997, through December 31, 2015. Patients receiving oral anticoagulant treatment at baseline were excluded, and person-time was censored at the time of treatment initiation (if any). CHA2DS2-VA scores were calculated for men and women, and were followed for up to 1 year in the Danish National Patient Registry. The primary outcome was a primary hospital code for ischemic stroke or systemic embolism (thromboembolism). We calculated crude event rates for risk strata as events per 100 person-years. For quantifying absolute risk of stroke, we calculated risks based on the pseudovalue method. Female sex as a prognostic factor was investigated by inclusion as an interaction term on the CHA2DS2-VA score to calculate the thromboembolic risk ratio for different score points. Results: A total of 239 671 patients with atrial fibrillation (48.7% women) contributed to the analyses. The mean ages for women and men were 76.6 years and 70.3 years, respectively; the mean CHA2DS2-VA scores were 2.7 for women and 2.3 for men. The overall 1-year thromboembolic rate per 100 person-years for women was 7.3 and 5.7 for men. The 1-year absolute risk of thromboembolism was 0.5% among men and women with a CHA2DS2-VA score of 0 and increased up to >7% among very comorbid patients (score >5). The risk ratio (male as reference) across points >1 indicated that women exhibit a higher stroke risk. The interaction was statistically significant (P<0.001). Conclusions: Female sex is a risk modifier for stroke in patients with atrial fibrillation. Initial decisions on oral anticoagulant treatment could be guided by a CHA2DS2-VA score (ie, excluding the sex category criterion), but the Sc risk component modifies and accentuates stroke risk in women who would have been eligible for oral anticoagulant treatment on the basis of ≥2 additional stroke risk factors.
Topographic Organization of Hippocampal Inputs to the Anterior Olfactory Nucleus

Top-down processes conveying contextual information play a major role in shaping odor representations within the olfactory system, yet the underlying mechanisms are poorly understood. The hippocampus (HPC) is a major source of olfactory top-down modulation, providing direct excitatory inputs to the anterior olfactory nucleus (AON). However, HPC-AON projections remain uncharacterized. In an effort to understand how hippocampal inputs are distributed within the AON, we systematically outlined their organization using anterograde and retrograde tracing methods. We found that AON-projecting hippocampal pyramidal neurons are located mostly in the ventral two-thirds of the HPC and are organized topographically such that cells with a ventral to intermediate hippocampal point of origin terminate, respectively, at the medial to lateral AON. Our neuroanatomical findings suggest a potential role for the HPC in the early processing and contextualization of odors which merits further investigation.
Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non–Small Cell Lung Cancer

Blocking CD47 interactions was a potent antitumor therapy for NSCLC. Cells resist death by increasing autophagy; simultaneously inhibiting autophagy provided a synergistic antitumor effect, providing a scientific basis for enhancing the efficacy of immune checkpoint inhibitors. CD47-specific antibodies and fusion proteins that block CD47–SIRPα signaling are employed as antitumor agents for several cancers. Here, we investigated the synergistic antitumor effect of simultaneously targeting CD47 and autophagy in non–small cell lung cancer (NSCLC). SIRPαD1-Fc, a novel CD47-targeting fusion protein, was generated and was found to increase the phagocytic and cytotoxic activities of macrophages against NSCLC cells. During this process, autophagy was markedly triggered, which was characterized by the three main stages of autophagic flux, including formation and accumulation of autophagosomes, fusion of autophagosomes with lysosomes, and degradation of autophagosomes in lysosomes. Meanwhile, reactive oxygen species and inactivation of mTOR were shown to be involved in autophagy initiation in SIRPαD1-Fc–treated cells, indicating a probable mechanism for autophagy activation after targeting CD47 by SIRPαD1-Fc. Inhibition of autophagy enhanced macrophage-mediated phagocytosis and cytotoxicity against SIRPαD1-Fc–treated NSCLC cells. In addition, simultaneously targeting both CD47 and autophagy in NSCLC xenograft models elicited enhanced antitumor effects, with recruitment of macrophages, activated caspase-3, and overproduction of ROS at the tumor site. Our data elucidated the cytoprotective role of autophagy in CD47-targeted therapy and highlighted the potential approach for NSCLC treatment by simultaneously targeting CD47 and autophagy. Cancer Immunol Res; 5(5); 363–75. ©2017 AACR. See related Spotlight by Kaufman, p. 355.
Sphingomyelin in microdomains of the plasma membrane regulates amino acid‐stimulated mTOR signal activation

Sphingomyelin (SM) is required for cells to proliferate, but the reason is not fully understood. In order to asses this question, we employed a cell line, ZS, which lacks both SMS1 and SMS2, isolated from mouse embryonic fibroblasts in SMS1 and 2 double knockout mouse, and SMS1 or SMS2 re‐expressing cells, ZS/SMS1 or ZS/SMS2, respectively. We investigated regulation of SM in activating the mammalian target of rapamycin (mTOR) signal induced by essential amino acids (EAA), using these cells. EAA‐stimulated mTOR signal was more activated in ZS/SMS1 and ZS/SMS2 cells than in controls. Treatment with methyl‐b‐cyclodextrin dramatically inhibited the activation. Interestingly, we found that the expression of CD98, LAT‐1 and ASCT‐2, amino acid transporters concerned with mTOR activation, was down‐regulated in ZS cells. Transporters localized in microdomains and formed a functional complex. Our results indicate that SM affect proliferation through the transport of amino acids via SM‐enriched microdomains.
Scaling Multicore Databases via Constrained Parallel Execution

Multicore in-memory databases often rely on traditional con- currency control schemes such as two-phase-locking (2PL) or optimistic concurrency control (OCC). Unfortunately, when the workload exhibits a non-trivial amount of contention, both 2PL and OCC sacrifice much parallel execution op- portunity. In this paper, we describe a new concurrency control scheme, interleaving constrained concurrency con- trol (IC3), which provides serializability while allowing for parallel execution of certain conflicting transactions. IC3 combines the static analysis of the transaction workload with runtime techniques that track and enforce dependencies among concurrent transactions. The use of static analysis simplifies IC3's runtime design, allowing it to scale to many cores. Evaluations on a 64-core machine using the TPC- C benchmark show that IC3 outperforms traditional con- currency control schemes under contention. It achieves the throughput of 434K transactions/sec on the TPC-C bench- mark configured with only one warehouse. It also scales better than several recent concurrent control schemes that also target contended workloads.
Blood Conservation in Cardiac Surgery

Cardiac surgery is one of the largest users of blood and blood products – currently estimated at 15% of UK blood stocks. While the blood supply could be considered to be the safest it has ever been, there are well recognised risks associated with the transfusion of red cells and blood products. It is appropriate that attempts should be made to decrease and optimise the transfusion of blood and blood products.
Scalable Energy Management for Low Voltage Microgrids Using Multi-Agent Storage System Aggregation

This paper proposes multi-agent energy storage system aggregation as a means of scaling energy management to low voltage microgrids with distributed energy storage systems. Based on this concept, a hierarchical control strategy is developed for an AC microgrid with distributed battery and ultracapacitor energy storage systems. On the tertiary control level, the energy management problem is made scalable by considering each type of energy storage system in aggregate. This addresses the “curse of dimensionality,” since additional energy storage systems do not increase the optimization problem dimension, and allows nonlinear energy storage models to be used for optimization, accounting for variable efficiency, self-discharge, and lifetime degradation. On the secondary control level, multi-agent state of charge balancing, reactive power sharing, frequency restoration, and voltage restoration are combined, to aggregate energy storage systems for the tertiary control. This includes the novel use of multi-agent sliding mode control for state of charge balancing between AC microgrid energy storage systems. Unlike a linear state of charge balancing strategy, circulating currents are prevented, increasing efficiency and reducing lifetime degradation. An RTDS Technologies real-time digital simulator was used to verify the performance of the proposed control strategy.
Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration

Proteomics studies have revealed that SUMOylation is a widely used post-translational modification (PTM) in eukaryotes. However, how SUMO E1/2/3 complexes use different SUMO isoforms and recognize substrates remains largely unknown. Using a human proteome microarray-based activity screen, we identified over 2500 proteins that undergo SUMO E3-dependent SUMOylation. We next constructed a SUMO isoform- and E3 ligase-dependent enzyme-substrate relationship network. Protein kinases were significantly enriched among SUMOylation substrates, suggesting crosstalk between phosphorylation and SUMOylation. Cell-based analyses of tyrosine kinase, PYK2, revealed that SUMOylation at four lysine residues promoted PYK2 autophosphorylation at tyrosine 402, which in turn enhanced its interaction with SRC and full activation of the SRC-PYK2 complex. SUMOylation on WT but not the 4KR mutant of PYK2 further elevated phosphorylation of the downstream components in the focal adhesion pathway, such as paxillin and Erk1/2, leading to significantly enhanced cell migration during wound healing. These studies illustrate how our SUMO E3 ligase-substrate network can be used to explore crosstalk between SUMOylation and other PTMs in many biological processes.
School-Based HIV/STD Testing Behaviors and Motivations Among Black and Hispanic Teen MSM: Results From a Formative Evaluation.

BACKGROUND This evaluation explores experiences with, and motivations for, human immunodeficiency virus (HIV) and sexually transmitted disease (STD) testing among black and Hispanic school-aged young men who have sex with men (YMSM). METHODS Participants were recruited at community-based organizations that serve YMSM in New York City, Philadelphia, and San Francisco. Eligible participants were 13- to 19-year-old black or Hispanic males who reported attraction to or sexual behavior with other males and/or identified as gay or bisexual, and attended at least 90 days of school in the previous 18 months. Participants (N = 415) completed web-based questionnaires and/or in-depth interviews (N = 32). RESULTS In the past year, 72.0% of questionnaire participants had been tested for HIV, 13.5% of them at school or school clinic. Participants reported that they would be more likely to get an HIV test if they could be tested close to or at school (34.4%), and 64.4% would use HIV testing if offered in schools. Most interview participants reported willingness to use school-based services if they were offered nonjudgmentally, privately, and confidentially by providers with experience serving YMSM. CONCLUSION Schools can provide opportunities to make HIV and STD testing accessible to school-aged YMSM, but the services must be provided in ways that are comfortable to them.
Surface tension powered self-assembly of 3-D micro-optomechanical structures

A new surface micromachining process for surface tension powered self-assembly of silicon-based microstructures is described. Mechanical parts are formed from bonded silicon-on-insulator material and rotated out-of-plane by melting photoresist pads at tow temperature. Simple mechanisms that allow accurate control of the final angle are introduced and used to construct fixed 45/spl deg/ mirrors and scanning mirror assemblies.
SCLERAL IMBRICATION COMBINED WITH VITRECTOMY AND GAS TAMPONADE FOR REFRACTORY MACULAR HOLE RETINAL DETACHMENT ASSOCIATED WITH HIGH MYOPIA

Purpose: To evaluate scleral imbrication with vitrectomy and gas tamponade for refractory macular hole retinal detachment associated with high myopia. Methods: We retrospectively reviewed the medical records of eight eyes with macular hole retinal detachment and high myopia treated with temporal scleral imbrication, pars plana vitrectomy, and gas tamponade for refractory macular hole retinal detachment with history of pars plana vitrectomy. Retinal reattachment and macular hole closure were assessed. Postoperative changes in axial length and surgically induced astigmatism were evaluated. Results: The retinas were reattached in all eyes and the macular holes closed in 6 (75%) eyes. The mean baseline logarithm of the minimum angle of resolution best-corrected visual acuity of 1.43 ± 0.48 significantly (P < 0.01) improved to 0.87 ± 0.34 at the final visit (889 ± 173 postoperative days). The mean baseline axial length of 29.5 ± 1.3 mm decreased significantly (P < 0.01) to 27.1 ± 1.9 mm 1 month after scleral imbrication and 28.1 ± 1.7 mm at the final visit (P < 0.05 vs. baseline, P = 0.13 vs. 1 month). The mean 1-month surgically induced astigmatism of 3.6 ± 1.4 diopters (D) after scleral imbrication significantly (P < 0.05) decreased to 2.4 ± 1.5 D at the final visit. Conclusion: Scleral imbrication with vitrectomy and gas tamponade resulted in high reattachment and macular hole closure rates for treating refractory macular hole retinal detachment.
Simultaneous Spectral-Spatial Feature Selection and Extraction for Hyperspectral Images

In hyperspectral remote sensing data mining, it is important to take into account of both spectral and spatial information, such as the spectral signature, texture feature, and morphological property, to improve the performances, e.g., the image classification accuracy. In a feature representation point of view, a nature approach to handle this situation is to concatenate the spectral and spatial features into a single but high dimensional vector and then apply a certain dimension reduction technique directly on that concatenated vector before feed it into the subsequent classifier. However, multiple features from various domains definitely have different physical meanings and statistical properties, and thus such concatenation has not efficiently explore the complementary properties among different features, which should benefit for boost the feature discriminability. Furthermore, it is also difficult to interpret the transformed results of the concatenated vector. Consequently, finding a physically meaningful consensus low dimensional feature representation of original multiple features is still a challenging task. In order to address these issues, we propose a novel feature learning framework, i.e., the simultaneous spectral-spatial feature selection and extraction algorithm, for hyperspectral images spectral-spatial feature representation and classification. Specifically, the proposed method learns a latent low dimensional subspace by projecting the spectral-spatial feature into a common feature space, where the complementary information has been effectively exploited, and simultaneously, only the most significant original features have been transformed. Encouraging experimental results on three public available hyperspectral remote sensing datasets confirm that our proposed method is effective and efficient.
An ATPG Method for Double Stuck-At Faults by Analyzing Propagation Paths of Single Faults

As fabricated circuitry becomes larger and denser, the modern industrial automatic test pattern generation techniques, which focus on the detection of single faults, become more likely to overlook multiple (simultaneous) faults. Although there are exponentially more multiple faults than single faults in any given circuit design, only a few additional test patterns are needed to cover all of the multiple faults, if the test generation starts from the complete test set for single faults. In this paper, we first show the case where test patterns for single faults are sufficient to cover all multiple faults, and then explain in which conditions some of the multiple faults may be overlooked. Based on this analysis, we propose a method that can efficiently generate the complete test set for double faults without traversing all the faults. Since most of the double faults can be detected by the single faults’ test set, the proposed method only selects the uncovered double faults by analyzing the propagation paths of single faults, and then generating new test patterns only for those uncovered faults. The experimental results show that based on the single faults’ test set, the proposed method only needs to create a small number of additional test patterns to cover all double faults in most of the given circuits. By repeating the same process, the proposed method can be incrementally applied to deal with all multiple faults.
New Views on Cesarean Section, its Possible Complications and Long-Term Consequences for Children’s Health

Historical developments and advancements in cesarean section techniques and logistics have reduced the maternal and neonatal risks associated with the procedure, while increasing the number of operatively completed pregnancies for medically unjustifiable reasons. The uncritical attitude towards cesarean section and the fast emergence of ‘modern’ diseases such as obesity at a young age, asthma, type 1 diabetes mellitus and various forms of dermatitis have stimulated researches associating cesarean section with these diseases. Intestinal flora of the children born by cesarean section contains less bifidobacteria, i.e. their intestinal flora is similar to the intestinal flora in diabetic individuals. In children born by cesarean section, the ‘good’ maternal bacterial that are normally found in the maternal birth canal and rectum are lacking, while the ‘bad’ bacteria that may endanger the child’s immune system are frequently present. In children born by vaginal delivery, the ‘good’ maternal bacteria stimulate the newborn’s white blood cells and other components of the immune system, which has been taken as a basis for the hypotheses explaining the evident association of the above morbidities and delivery by cesarean section.
Park Smart

The paper presents Park Smart, a solution which aim is to solve the pain of finding a free parking space in public and private areas (e.g. cities, malls, etc.), and hence to optimize parking stalls allocation as well as to increase revenues for the companies which manage them. The proposed solution exploits cutting edge technologies such as IoT, Cloud Computing and Deep Learning.
Adaptive model-free consensus control for a network of nonlinear agents under the presence of measurement noise

In this paper, a decentralized model-free consensus control is proposed for a network of nonlinear agents with unknown nonlinear dynamics, unknown process disturbances and white noise measurement disturbances. Here, the main purpose of control protocol is to first synchronize the states of all follower agents in the network to a leader and then track a reference trajectory in the systems state-space. Here, the leader has at least one information connection with one of the follower agents in the network. The design procedure includes adaptive laws for estimating the unknown linear and nonlinear terms of each agent's dynamics. The estimation for nonlinear terms is in a model-free format. Moreover, a robust observer is designed to approximate the values of leader's control parameters at the agents without connection to the leader. Another observer is incorporated to filter the noisy measurements of the system states. The entire design procedure is analysed successfully for the stability using Lyapunov stability theorem. Finally, the simulation results for application of the algorithm on a network of Duffing-Holmes chaotic systems are presented.
Mean Hearing Thresholds Among School Children in Taiwan

Objectives: The primary aim of this study was to obtain the mean hearing thresholds among school-age children residing in the Datong and Jhongshan Districts of Taipei City, Taiwan. Design: Hearing thresholds were obtained from a stratified sample of 1411 students in grades 1, 4, 7, and 10 based on their participation in the annual health examination of school-age children carried out by the Taipei City Government. After otoscopic examination, audiometric testing was undertaken at 0.5 to 4 kHz along with tympanometric screening. The means and SDs obtained from these examinations are reported by grade, gender, ear, and frequency. Results: The mean hearing thresholds ranged between 6.8 and 16.7 dB HL, with the highest (poorest) hearing threshold being obtained at a test frequency of 0.5 kHz. At all the tested frequencies, the hearing thresholds of boys were found to be higher than those of girls. Logistic regressions demonstrating that those students with the highest odds ratios of hearing loss were to be found in the sample of children in grade 1. The odds ratios of hearing loss were also found to be higher among boys than girls and for the left ear rather than the right. Conclusions: These results indicate that the mean thresholds among the study sample were well above (meaning poorer) the pure-tone average of 15 dB HL, as recommended in a previous study. Therefore, the results of this study suggest the need to further determine the etiology of hearing loss among children in grades 1, 4, 7, and 10 in the Datong and Jhongshan Districts of Taipei City and perhaps Taiwan.