Miracle-dz/UniFAR-FTUs huggingface dataset:
On The Protection by The Combination of CeO2 Nanoparticles and Sodium Selenite on Human Lymphocytes against Chlorpyrifos-Induced Apoptosis In Vitro

Objective Chlorpyrifos (CP) as an organophosphorus pesticide is thought to induce oxidative stress in human cells via producing reactive oxygen species (ROS) that leads to the presence of pathologic conditions due to apoptosis along with acetylcholinesterase (AChE) inhibition.This study aimed to evaluate the apoptotic effects of CP and to assess the protective potential of CeO2nanoparticle (CNP) and sodium selenite (SSe) by measuring cascades of apoptosis, oxidative stress, inflammation, and AChE inhibition in human isolated lymphocytes. Materials and Methods In the present experimental study, we examined the anti-oxidative and AChE activating potential of CNP and SSe in CP-treated human lymphocytes. Therefore, the lymphocytes were isolated and exposed to CP, CP+CNP, CP+SSe, and CP+CNP+SSe after a three-day incubation. Then tumor necrosis factor-alpha (TNF-α) release, myeloperoxidase (MPO) activity, thiobarbituric acid-reactive substances (TBARS) levels as inflammatory/oxidative stress indices along with AChE activity were assessed. In addition, the apoptotic process was measured by flow cytometry. Results Results showed a significant reduction in the mortality rate, TNF-α, MPO activity, TBARS, and apoptosis rate in cells treated with CNP, SSe and their combination. Interestingly, both CNP and SSe were able to activate AChE which is inhibited by CP. The results supported the synergistic effect of CNP/SSe combination in the prevention of apoptosis along with oxidative stress and inflammatory cascade. Conclusion CP induces apoptosis in isolated human lymphocytes via oxidative stress and inflammatory mediators. CP firstly produces ROS, which leads to membrane phospholipid damage. The beneficial effects of CNP and SSe in reduction of CP-induced apoptosis and restoring AChE inhibition relate to their anti-oxidative potentials.
Analysis of Healthcare Workflows in Accordance with Access Control Policies

Healthcare information systems deal with sensitive data across complex workflows. They often allow various stakeholders from different environments to access data across organizational boundaries. This elevates the risk of exposing sensitive healthcare information to unauthorized personnel, leading ‘controlling access to resources' a major concern. To prevent unwanted access to sensitive information, healthcare organizations need to adopt effective workflows and access control mechanisms. Many healthcare organizations are not yet considering or do not know how to accommodate the ‘context' element as a crucial element in their workflows and access control policies. The authors envision the future of healthcare where ‘context' will be considered as a crucial element. They can accommodate context through a new element ‘environment' in workflows, and can accommodate context in policies through well-known attribute based access control mechanism (ABAC). This research mainly addresses these problems by proposing a model to integrate workflows and access control policies and thereby identifying workflow activities that are not being protected by access control policies and improving the workflow activities and/or existing access control policies using SARE (Subject, Action, Resource, and environment) elements.
A novel robot for arm motor therapy with homogeneous mechanical properties

Robotic platforms developed to assist conventional motor therapy and to investigate human motor control have received an increasing interest over the past decades. However, for most of the proposed solutions, bulkiness and expensiveness have limited the use of such devices to specialized clinics that can afford their cost. This paper presents the H-Man, a two degree-of-freedom planar device designed according to three main principles: cost-effectiveness, portability and ease of control. The key component of the device is a planar H-shaped cable differential mechanism which ensures a constant Jacobian and homogeneous perceived inertia over the entire workspace. The paper presents the mechanical design as well as the performance evaluation in terms of perceived impedance.
A Min-Edge Cost Flow Framework for Capacitated Covering Problems

In this work, we introduce the Cov-MECF framework, a special case of minimum-edge cost flow in which the input graph is bipartite. We observe that several important covering (and multi-covering) problems are captured in this unifying model and introduce a new heuristic LPO for any problem in this framework. The essence of LPO harnesses as an oracle the fractional solution in deciding how to greedily modify the partial solution. We empirically establish that this heuristic returns solutions that are higher in quality than those of Wolsey's algorithm. We also apply the analogs of Leskovec et. al.'s [25] optimization to LPO and introduce a further freezing optimization to both algorithms. We observe that the former optimization generally benefits LPO more than Wolsey's algorithm, and that the additional freezing step often corrects suboptimalities while further reducing the number of subroutine calls. We tested these implementations on randomly generated testbeds, several instances from the Second DIMACS Implementation Challenge and a couple networks modeling realworld dynamics.
AI Meets Online Dating Predicting Attractiveness in Profile Pictures

We construct a learning model to predict the attractiveness of facial images. We use a face detection API to tag several facial landmarks and use the pairwise distances between these landmarks as the features for our model. We find that our model rates images similarly to humans, making the same rating that an average human would nearly three quarters of the time. Our work may be useful for the online dating community and/or computer vision community.
Design By Contract. The Eiffel Method

It is indeed possible to use object-oriented technology to produce, almost routinely, software systems that reach a degree of reliability without any equivalent in conventional methods, languages and tools. This requires a strict application of pure object-oriented concepts, in particular seamlessness (the use of a consistent method and notation throughout the software lifecycle), information hiding, automatic garbage collection, static typing, and the combination of static typing and dynamic binding. Another key component of this approach is the notion of design by contract, which leads to the production of system whose correctness is built-in rather than ensured ex post facto.
Bath Salts and Other Emerging Toxins

Abstract Novel classes of synthetic drugs, including synthetic cathinones (“bath salts”) and synthetic cannabinoids (“spice” or “K2”), have recently emerged as popular drugs of abuse. Salvia divinorum, a naturally occurring herb, has gained popularity in the last decade as a hallucinogenic as well. The legal status of these substances has been undergoing rapid changes and has been confusing to lawmakers and medical practitioners alike. We present an up-to-date information about the legality of these substances. We also discuss the historical background, chemical composition, patterns of abuse, clinical presentations, laboratory analysis, and management strategies for these drugs, with an emphasis on synthetic cathinones.
The Impact of Internal Migration on under-Five Mortality in 27 Sub-Saharan African Countries

Objective The literature on the impact of internal migration on under-five mortality in sub-Saharan Africa has been limited. This study examined the impact of internal migration on under-five mortality rate in 27 sub-Saharan African countries. Design The analysis used cross-sectional data from the most recent Demographic and Health Surveys of 27 sub-Saharan African countries. Information on the number of live births and the number of under-five deaths in the five years preceding the surveys in these countries was examined. Using variables from which migration data were generated, four migration statuses were computed, and the impact of each migration status on under-five mortality was analysed by using multivariate Cox proportional hazards regression models. Results Of the 96333 live births, 7036 deaths were reported. In the unadjusted model, we found that, compared to urban non-migrant mothers, hazard of under-five mortality was 20% [HR: 1.20; 95% confidence interval (CI): (1.06–1.35)], 40% [HR: 1.40; 95% CI: (1.29–1.53)], and 43% [HR: 1.43; 95% CI: (1.30–1.58)] higher among urban-rural migrant, rural non-migrant, and rural-urban migrant mothers respectively. The likelihood of children dying did not change considerably when country and demographic variables were adjusted for. However, after controlling for health care service utilization factors, the results remained consistently significant for rurality. That is, mortality rates remained significantly higher among children of rural non-migrant [(HR: 1.20; 95% CI: (1.08–1.33), P-value (p) < 0.001] and rural-urban migrant [HR: 1.29; 95% CI: (1.15–1.45), p < 0.001] mothers than those of urban non-migrant mothers. Conclusion Although under-five child mortality rate declined by 52% between 1990 and 2015 (from 179 to 86 per1000 live births) in sub-Saharan Africa, the continent still has the highest rate in the world. This finding highlights the need to consider providing education and health care services in rural areas, when implementing interventions meant to reduce under-five mortality rates among internal migrant mothers.
CD8+-Cell-Mediated Suppression of Virulent Simian Immunodeficiency Virus during Tenofovir Treatment

ABSTRACT The ability of tenofovir to suppress viremia in simian immunodeficiency virus (SIV)-infected macaques for years despite the presence of virulent viral mutants with reduced in vitro susceptibility is unprecedented in this animal model. In vivo cell depletion experiments demonstrate that tenofovir's ability to suppress viremia during acute and chronic infection is significantly dependent on the presence of CD8+ lymphocytes. Continuous tenofovir treatment was required to maintain low viremia. Although it is unclear whether this immune-mediated suppression of viremia is linked to tenofovir's direct antiviral efficacy or is due to independent immunomodulatory effects, these studies prove the concept that antiviral immune responses can play a crucial role in suppressing viremia during anti-human immunodeficiency virus drug therapy.
A Novel Form of Short QT Syndrome (SQT3) Is Caused by a Mutation in the KCNJ2 Gene

Short QT syndrome (SQTS) leads to an abbreviated QTc interval and predisposes patients to life-threatening arrhythmias. To date, two forms of the disease have been identified: SQT1, caused by a gain of function substitution in the HERG (IKr) channel, and SQT2, caused by a gain of function substitution in the KvLQT1 (IKs) channel. Here we identify a new variant, “SQT3”, which has a unique ECG phenotype characterized by asymmetrical T waves, and a defect in the gene coding for the inwardly rectifying Kir2.1 (IK1) channel. The affected members of a single family had a G514A substitution in the KCNJ2 gene that resulted in a change from aspartic acid to asparagine at position 172 (D172N). Whole-cell patch-clamp studies of the heterologously expressed human D172N channel demonstrated a larger outward IK1 than the wild-type (P<0.05) at potentials between −75 mV and −45 mV, with the peak current being shifted in the former with respect to the latter (WT, −75 mV; D172N, −65 mV). Coexpression of WT and mutant channels to mimic the heterozygous condition of the proband yielded an outward current that was intermediate between WT and D172N. In computer simulations using a human ventricular myocyte model the increased outward IK1 greatly accelerated the final phase of repolarization, and shortened the action potential duration. Hence, unlike the known mutations in the two other SQTS forms (N588K in HERG and V307L in KvLQT1), simulations using the D172N and WT/D172N mutations fully accounted for the ECG phenotype of tall and asymmetrically shaped T waves. Although we were unable to test for inducibility of arrhythmia susceptibility due to lack of patients’ consent, our computer simulations predict a steeper steady-state restitution curve for the D172N and WT/D172N mutation, compared with WT or to HERG or KvLQT1 mutations, which may predispose SQT3 patients to a greater risk of reentrant arrhythmias.
Immunologic properties of differentiated and undifferentiated mesenchymal stem cells derived from umbilical cord blood

The expression of immunogenic markers after differentiation of umbilical cord blood (UCB)-derived mesenchymal stem cells (MSC) has been poorly investigated and requires extensive in vitro and in vivo testing for clinical application. The expression of human leukocyte antigen (HLA) classes on UCB-derived MSC was tested by Fluorescence-activated cell sorting analysis and immunocytochemical staining. The undifferentiated MSC were moderately positive for HLA-ABC, but almost completely negative for HLA-DR. The MSC differentiated to chondrocytes expressed neither HLA-ABC nor HLA-DR. The proliferation of MSC was not significantly affected by the allogeneic lymphocytes stimulated with concanavalin A. The responder lymphocytes showed no significant decrease in proliferation in the presence of the MSC, but the apoptosis rate of the lymphocytes was increased in the presence of MSC. Taken together, these findings indicate that UCB-derived MSC differentiated to chondrocytes expressed less HLA class I and no class II antigens. The MSC showed an immunomodulatory effect on the proliferation and apoptosis of allogeneic lymphocytes. These data suggest that the differentiated and undifferentiated allogeneic MSC derived from umbilical cord blood can be a useful candidate for allogeneic cell therapy and transplantation without a major risk of rejection.
Thrombotic Processes in Multiple Sclerosis as Manifestation of Innate Immune Activation

Multiple sclerosis (MS) is a chronic demyelinating inflammatory disease of the central nervous system (CNS) affecting prevalently young adults (1, 2). The pathogenesis of MS has long been attributed to self-reactive T cells but recently the relevant role of B cells has also been recognized (2, 3). Furthermore, it has been demonstrated that innate immunity has a pivotal role in the beginning and in advanced stages of MS (4–6). Innate immunity represents the immediate non-specific defense against infections and dangerous agents acting through its essential arms such as inflammation and blood coagulation (7–10). The coagulant processes are normally balanced by the natural anti-coagulant system needed to limit the host damage, and their imbalance leads to venous thrombosis (7, 8). Many evidences reported below support a significant presence of local and systemic thrombotic events in MS confirming the global over-stimulation of innate immunity for both its inflammatory and coagulant components.
Diffusion-weighted imaging of acute corticospinal tract injury preceding Wallerian degeneration in the maturing human brain.

BACKGROUND AND PURPOSE Wallerian degeneration, the secondary degeneration of axons from cortical and subcortical injury, is associated with poor neurologic outcome. Since diffusion-weighted (DW) imaging is sensitive to early changes of cytotoxic edema, DW imaging may depict the acute injury to descending white matter tracts that precedes Wallerian degeneration; this injury is not visible on conventional CT or MR images in the maturing human brain. METHODS Two neuroradiologists retrospectively analyzed clinical MR images in six children (aged 3 days to 5 months) with DW findings consistent with acute injury of the descending white matter tract due to territorial anterior or middle cerebral artery infarction. In five patients, images were obtained as a part of routine clinical evaluation. The remaining patient was a part of a prospective study of brain injury. Imaging findings were correlated with clinical outcomes. RESULTS In all six patients, DW imaging performed 2-8 days after the onset of ischemia depicted injury to the descending white matter tract ipsilateral to the territorial infarct. Conventional MR images of the ipsilateral descending white matter tracts were abnormal in three patients. In all five patients for which follow-up results were available, the presence of DW changes was correlated with persistent neurologic disability. CONCLUSION As shown in this retrospective analysis, DW imaging can depict acute injury to the descending white matter tract in neonates and infants, when conventional MR imaging may show normal findings. These DW findings likely precede the development of Wallerian degeneration, and they may portend a poor clinical outcome.
State-Dependent Contribution of the Hyperpolarization-Activated Na+/K+ and Persistent Na+ Currents to Respiratory Rhythmogenesis In Vivo

How rhythms are generated by neuronal networks is fundamental to understand rhythmic behaviors such as respiration, locomotion, and mastication. Respiratory rhythm is generated by the preBötzinger complex (preBötC), an anatomically and functionally discrete population of brainstem neurons, central and necessary for respiratory rhythm. In specific in vitro conditions, preBötC neurons depend on voltage-dependent inward currents to generate respiratory rhythm. In the mature and intact organism, where preBötC neurons are deeply embedded in the respiratory network, the contribution of ionic currents to respiratory rhythm is unclear. We propose that a set of ionic currents plays a key role in generating respiratory rhythm in the mature organism in vivo. By microperfusing ionic current blockers into the preBötC of adult rats, we identify the hyperpolarization-activated cation current as a critical component of the mechanism promoting respiratory rhythm, and that this current, in combination with the persistent sodium current, is essential to respiratory rhythm in vivo. Importantly, both currents contribute to rhythmic activity in states of anesthesia, quiet wakefulness, and sleep, but not when the organism is engaged in active behaviors. These data show that a set of ionic currents at the preBötC imparts the network with rhythmicity in reduced states of arousal, although the network can override their contribution to adjust its activity for nonrhythmic behaviors in active wakefulness.
Fast, compact, and lightweight shape-shifting system composed of distributed self-folding origami modules

In this paper, we propose a new shape-shifting system. Shape-shifting is achieved by the integration of arranged identical transformable units. These are self-folding origami modules that transform their shape from a cubic to a flat shape, and vice versa, similarly to a three-dimensional (3D) morphing pixel. By changing the shape of individual modules, the system can generate desired shapes. Each module is based on a modified Kresling pattern, which has bi-stability during deployment so that it can maintain its shape in both states without any actuator force. Also, it can rapidly and reversibly transform its shape via folding and unfolding motions that are generated by a low-profile torsional SMA wire actuator positioned at fold lines. This approach is a hybrid of the modular and folding approaches so that the system can generate shape-shifting without complicated communication methodology between modules and bulky infrastructure, and has fast, compact and lightweight hardware. We demonstrate performance with a 3×3 matrix form of this module (40 mm side length) that can make five different shapes and it required only 15 seconds per transformation. This new shape-shifting system could be applied to design multi-functional self-folding origami such as a morphing 3D map.
A Grounded Ontology for Identity and Reference of Web Resources

The identity and reference of web resources used to be a critical subject, and recently it has become a key item in the research agenda of web science. After an introduction to the research related to web identity and reference, we present a new version of IRE, an OWL ontology of web resources and their referencing kinds. Finally, as a case study, we describe an implementation of IRE. Specifically, we show how IRE theory has been used to implement a semantic web application which supports the ontology-driven development and evolution of semantic web portals.
Exact Interior Reconstruction from Truncated Limited-Angle Projection Data

Using filtered backprojection (FBP) and an analytic continuation approach, we prove that exact interior reconstruction is possible and unique from truncated limited-angle projection data, if we assume a prior knowledge on a subregion or subvolume within an object to be reconstructed. Our results show that (i) the interior region-of-interest (ROI) problem and interior volume-of-interest (VOI) problem can be exactly reconstructed from a limited-angle scan of the ROI/VOI and a 180 degree PI-scan of the subregion or subvolume and (ii) the whole object function can be exactly reconstructed from nontruncated projections from a limited-angle scan. These results improve the classical theory of Hamaker et al. (1980).
What Sign Language Reveals about the Critical Period for Language

This chapter examines the critical period for language through the prism of deafness.The first topic is the concept of critical periods, followed by a summary of research investigating age of acquisition effects on the outcome of second-language learning (L2). The phenomenon of late first-language (LI) acquisition among deaf children is then described.The focus of this chapter is on a series of studies that compare and contrast the long-range outcome of LI and L2 acquisition in relation to age of acquisition. The effects of late LI acquisition are greater than those for L2 learning. The effects include a compromised ability to process and understand all forms of language. Late LI acquisition has deleterious effects on the ability to learn other languages and on reading development.The findings come from experiments in American Sign Language (ASL) and English using a variety of psycholinguistic paradigms across levels of linguistic structure and include narrative comprehension and shadowing, sentence shadowing and memory, grammatical judgment, and reading comprehension. How these psycholinguistic phenomena illuminate the critical period for language is then discussed.
Stimulated nuclear translocation of NF-κB and shuttling differentially depend on dynein and the dynactin complex

Translocation from the cytoplasm to the nucleus is required for the regulation of gene expression by transcription factors of the nuclear factor kappa B (NF-κB) family. The p65:p50 NF-κB heterodimer that predominates in many cell types can undergo stimulated movement, following degradation of the IκB inhibitor, as well as shuttling in the absence of stimulation with IκB bound. Disruption of the dynactin complex and knockdown of endogenous dynein were used to investigate the nuclear translocation requirements for stimulated and shuttling movement of NF-κB. A differential dependence of these two modes of transport on the dynein molecular motor and dynactin was found. NF-κB used active dynein-dependent transport following stimulation while translocation during shuttling was mediated by a dynein-independent pathway that could be potentiated by dynactin disruption, consistent with a process of facilitated diffusion. Nuclear translocation and activation of NF-κB-dependent gene expression showed a dependence on endogenous dynein in a variety of cell types and in response to diverse activating stimuli, suggesting that dynein-dependent transport of NF-κB may be a conserved mechanism in the NF-κB activation pathway and could represent a potential point of regulation.