Miracle-dz/UniFAR-FTUs huggingface dataset:
Automated Security Test Approach for SIP-based VoIP Softphones

Voice over Internet Protocol based systems become more and more part of business critical IT infrastructures. To increase the robustness of voice applications, automated security testing is required to detect security vulnerabilities in an efficient way. In this paper we present a fuzzer framework to detect security vulnerabilities in Voice over Internet Protocol Softphones, which implement Session Initiation Protocol. The presented approach automates the Graphical User Interface interaction for softphones during fuzzing and also observes the behavior of the softphone Graphical User Interfaces to automatically detect application errors. Results of testing two open source softphones by using our fuzzer showed that various unknown vulnerabilities could be identified with the implemented fuzzer and some vulnerabilities were found that are only detectable by using Graphical User Interface observation.
Identification, Characterization, and Structure of Tm16 from Trichuris muris

Trichuriasis is a disease of poverty for which excretory and secretory (ES) products that induce the protective immunity are being investigated as candidate vaccines antigens. In this study, ES products of T. muris and immune sera were produced. The immune sera recognized more than 20 proteins on a 2D-gel of ES products of T. muris adult worms. Tm16 was one of the proteins identified by mass spectrometry. Tm16 shares 57% sequence identity with Ov16, an immunodominant diagnostic antigen from Onchocerca volvulus. Recombinant Tm16 with a carboxyl terminal hexahistidine was produced using Pichia pastoris. Polyclonal antibodies against rTm16 were generated by one-prime and two-boost immunization of three female Balb/c mice with 25 μg of recombinant Tm16 emulsified with ISA720 adjuvant. These polyclonal antibodies confirmed that Tm16 is localized to the ES products and the soluble fraction of the adult worm. Additionally, the high-resolution crystal structure of Tm16 was solved by molecular replacement. Tm16 belongs to the phosphatidylethanolamine-binding-like protein (PEBP1) family and this is the first structure of a PEBP1 from a parasite.
Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG

Hypothermia has a profound impact on the electrophysiological mechanisms of the heart. Experimental investigations provide a better understanding of electrophysiological alterations associated with cooling. However, there is a lack of computer models suitable for simulating the effects of hypothermia in cardio-electrophysiology. In this work, we propose a model that describes the cooling-induced electrophysiological alterations in ventricular tissue in a temperature range from 27°C to 37°C. To model the electrophysiological conditions in a 3D left ventricular tissue block it was essential to consider the following anatomical and physiological parameters in the model: the different cell types (endocardial, M, epicardial), the heterogeneous conductivities in longitudinal, transversal and transmural direction depending on the prevailing temperature, the distinct fiber orientations and the transmural repolarization sequences. Cooling-induced alterations on the morphology of the action potential (AP) of single myocardial cells thereby are described by an extension of the selected Bueno-Orovio model for human ventricular tissue using Q10 temperature coefficients. To evaluate alterations on tissue level, the corresponding pseudo electrocardiogram (pECG) was calculated. Simulations show that cooling-induced AP and pECG-related parameters, i.e. AP duration, morphology of the notch of epicardial AP, maximum AP upstroke velocity, AP rise time, QT interval, QRS duration and J wave formation are in good accordance with literature and our experimental data. The proposed model enables us to further enhance our knowledge of cooling-induced electrophysiological alterations from cellular to tissue level in the heart and may help to better understand electrophysiological mechanisms, e.g. in arrhythmias, during hypothermia.
Judicial Retirement Strategies

If judges are politically strategic, they may try to retire at times that maximize the chances that an ideologically compatible successor will be appointed. Using biographical data on all appellate judges who have retired since 1892, a heteroscedastic panel probit model is used to examine retirement timing as a function of personal and political factors. We determine whether retirement from the bench can be explained exclusively by personal factors such as salary, pension, and workload, or if political considerations enter into the decision. The data reveal that retirement decisions are affected primarily by nonpolitical considerations, but presidential elections may factor into a judge's decision. The only important strategic political consideration in evidence is whether a judge contemplating retirement faces an opposing party president and how far off that president's next election is.
Discussion on the Transformation of Enterprise Production Management Model in the Environment of ERP

—Production management is the process of production manufacturing and plays a crucial role in manufacturing enterprises. With the continuous progress and development of information technology and management methods, more and more companies use ERP systems for production management. After analyzing of tools such as master production schedule, material requirement planning, capability requirement planning and shop floor management in ERP system, the changes and impacts of the enterprise application ERP system to the enterprise production management methods are derived
Polarization analyzing CMOS sensor for microchamber/microfluidic system based on image sensor technology

Image sensor-based polarization analyzing CMOS sensor that will be integrated on the microchamber or microfluidic system is proposed. A CMOS image sensor with 2 x 2 -parallel operation scheme is designed for the polarization analysis. Embedded wire grid polarizer with various grid angles was configured on the photodiodes. The basic function of the polarization analyzing sensor is experimentally demonstrated, too. Polarization profile measurement and polarimetric measurement are successfully demonstrated with a photosensor array designed for the proposed measurement scheme.
Novel FLT3 tyrosine kinase inhibitors

Acute myeloid leukaemia (AML) is an aggressive haematological malignancy that is curable in ~ 40% of cases. Activating mutations of the receptor tyrosine kinase FLT3 (FMS-like tyrosine kinase-3) are the single most common molecular abnormalities in AML and are associated with a distinctly worse prognosis. In an effort to target this mutation and improve outcomes in this subgroup of AML patients, several novel small-molecule FLT3 tyrosine kinase inhibitors are currently in development. Some of these FLT3 inhibitors are useful only as laboratory tools, while others clearly have clinical potential. These compounds are derived from a wide variety of chemical classes and differ significantly both in their potency and selectivity. This review summarises these developments and examines these novel agents with regard to both the assays used to characterise them and their clinical potential.
Learning to work : the intermediate labour market response to social exclusion

Since New Labour was elected to government in 1997, policy-makers' responses to the complex problems of social exclusion have been almost exclusively focused on promoting paid work as the best way to address the issue. Policy measures in areas such as employment, education, and lifelong learning have all tended to prioritise the improvement of labour market supply-side skills as a means of moving people from social exclusion, characterised as long term unemployment and inactivity, towards successful engagement in the labour market. One measure which has been put in place to address issues of social exclusion is the Intermediate Labour Market (ILM). ILMs are holistic work experience interventions which aim to improve the employability of people who are at some distance from the labour market in order to move them into sustainable employment. They offer a period of temporary, paid employment together with a range of personalised support measures which aim to counter an individual's barriers to work. While focused on improving labour market supply, ILMs also create a 'market for intermediate labour' in which new, temporary jobs are developed, especially in the voluntary and community, or social enterprise,'third' sectors.During the years 2001 to 2004, Objective 1 in South Yorkshire financed a large ILM programme (SYCON ILM) which operated across the South Yorkshire sub-region and which was the case study example for this research project. The study developed a realistic evaluation approach, informed by critical realism, in order to assess the 'structures of employment' which SYCON created. It aimed to better understand the roles of individuals who participated in the programme, and to assess the enabling mechanisms which were triggered by their participation. This study has contributed to knowledge of realist methods and approaches, especially by developing an analytical framework, based on isolating contexts and mechanisms, with which to assess realist data collected from a variety of sources. It has also contributed to academic literature in the field of skills and learning, especially in relation to debates on the value of low level vocational qualifications, and those around aesthetic and emotional labour. The study engaged with discourses of 'the underclass', 'Chavs' and 'NEETS' but found no evidence of a widespread 'benefits culture' among the previously disengaged ILM participants. The implications of the study for policy interventions have been outlined and further research suggested.
Business Scenarios for the Ecosystem Surrounding Licensed Shared Access

Licensed Shared Access (LSA) is a regulatory approach in spectrum sharing which aims to meet the requirements of the high demand after frequency spectrum. Allowing incumbent spectrum users (license holders of the frequency bands) to share their underutilized spectrum with a limited number of LSA licensees (secondary users), LSA guarantees certain Quality of Service (QoS) under pre-defined sharing conditions between them. There exists numerous works related to the concept of spectrum sharing and LSA. Considering several studies only look at Mobile Network Operators (MNOs) as service providers wanting to use spectrum shared by license holders, there are limitations needed to be challenged. To ensure a streamlined migration from the traditional exclusive spectrum access to LSA, several aspects have to be examined. This thesis presents the business scenarios for LSA and its surrounding ecosystem. Possible deployment strategies and a business model for LSA will be presented, along with examination of ecosystem actors and corresponding benefits for those actors. Finally, an SCOC-Analysis will be provided for strategic decisions to understand the different strengths, opportunities and challenges for the deployment of LSA. A business model for LSA is provided by the Osterwalder business model canvas to answer what the cost structures look like and what the revenue streams devoted to LSA are. Furthermore, an strategic SCOC-analysis for LSA is proposed, and several challenges are addressed, including adoption of new technology and cross-border challenges. Lastly, the current state of the development of LSA and the technologies needed are presented along with possible reactions from key ecosystem actors for deployment strategies towards LSA. Conclusively, in order to assist for the progress of the adoption of LSA, regulators and standardization organizations have to establish compatibility and omnipresent deployment.
ChromothripsisDB: a curated database of chromothripsis

UNLABELLED Chromothripsis is a single catastrophic event that can lead to massive genomic rearrangements confined to one or a few chromosomes. It provides an alternative paradigm in cancer development and changes the conventional view that cancer develops in a stepwise progression. The mechanisms underlying chromothripsis and their specific impact on tumorigenesis are still poorly understood, and further examination of a large number of identified chromothripsis samples is needed. Unfortunately, this data are difficult to access, as they are scattered across multiple publications, come in different formats and descriptions, or are hidden in figures and supplementary materials. To improve access to this data and promote meta-analysis, we developed ChromothripsisDB, a manually curated database containing a unified description of all published chromothripsis cases and relevant genomic aberrations. Currently, 423 chromothripsis samples representing 107 research articles are included in our database. ChromothripsisDB represents an extraordinary resource for mining the existing knowledge of chromothripsis, and will facilitate the identification of mechanisms involved in this phenomenon. AVAILABILITY AND IMPLEMENTATION ChromothripsisDB is freely available at http://cgma.scu.edu.cn/ChromothripsisDB CONTACT: haoyang.cai@scu.edu.cn SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Streptococcus milleri Pyomyoma Simulating Infective Endocarditis

A 37-year-old woman with clinically occult, abscessed uterine myomas presented with fever, anemia, splenomegaly, and viridans streptococcal bacteremia. An initial diagnosis of endocarditis was made, but fever persisted despite appropriate antibiotics. Pelvic pain evolved and laparotomy revealed an infected myoma. Streptococcus milleri was isolated from both the blood and the uterine abscess. Infected uterine myomata may be clinically silent despite producing sustained bacteremia. The occurrence of suppurating myomas and the significance of S milleri isolates are briefly reviewed.
Low Complexity Channel Estimation for OFDM Systems Based on LS and MMSE Estimators

In this paper we investigate the block-type pilot channel estimation for orthogonal frequency-division multiplexing (OFDM) systems. The estimation is based on the minimum mean square error (MMSE) estimator and the least square (LS) estimator. We derive the MMSE and LS estimators’ architecture and investigate their performances. We prove that the MMSE estimator performance is better but computational complexity is high, contrary the LS estimator has low complexity but poor performance. For reducing complexity we proposed two different solutions which are the Simplified Least Square (SLS) estimator and the modified MMSE estimator. We evaluate estimator’s performance on basis of mean square error and symbol error rate for 16 QAM systems. We also evaluate estimator’s computational complexity.
Predictors of Outcome During a 6-Month Follow-Up Among Heroin Dependent Patients Receiving Buprenorphine/Naloxone Maintenance Treatment

ABSTRACTObjective: The aim of this study was to evaluate the predictors of outcome during a 6-month follow-up among heroin dependent patients receiving buprenorphine/naloxone (BN) maintenance treatment.Methods: Three hundred and ninety-two heroin dependent patients, who were consecutively admitted to the clinic (n=106, 27.04%) or accepted as outpatients for BN maintenance treatment (n=286, 72.96%) were included in the study. Patients were investigated with the Bakirkoy Opioid Withdrawal Scale (BOWS), the Substance Craving Scale (SCS), the Drug Use Disorders Identification Test (DUDIT), the Drug Abuse Screening Test (DAST-10) and the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES) at baseline evaluation.Results: Among 392 heroin dependent patients, 287 (73.21%) were considered to have relapsed to substance use or to have dropped out of treatment, whereas 105 (26.79%) were considered to be compliant to the BN maintenance treatment. Rates of having a first degree relative with substance a.
Regulation of Virus Release by the Macrophage-Tropic Human Immunodeficiency Virus Type 1 AD8 Isolate Is Redundant and Can Be Controlled by either Vpu or Env

ABSTRACT The human immunodeficiency virus type 1 (HIV-1) Vpu and Env proteins are expressed from a bicistronic mRNA. To address the biological significance of the coordinated expression ofvpu and env, we compared the relative effects on particle release of HIV-1 isolates containing an intactvpu gene or carrying point mutations in its initiation codon or internal deletions, respectively. We found that the primary AD8 isolate, which is unable to express vpu due to a mutation in its translation initiation codon, was able to replicate in primary macrophages and peripheral blood mononuclear cells with efficiency similar to that of an isogenic variant expressing Vpu. Interestingly, AD8 lacking a vpu initiation codon produced higher levels of Env protein than its Vpu-expressing isogenic variant. In contrast, disabling Vpu without removing the vpuinitiation codon did not alter Env expression but significantly reduced virus production. AD8 Env when provided in trans was capable of enhancing release not only of AD8 particles but also of viruses of the T-cell-tropic NL4-3 isolate. We conclude that AD8 Env encodes a Vpu-like activity similar to that previously reported for HIV-2 Env proteins and is thus able to augment virus secretion. When expressed at elevated levels, i.e., following mutation of thevpu initiation codon, AD8 Env was able to compensate for the lack of Vpu and thereby ensure efficient virus release. Thus, the ability to regulate virus release is redundant in AD8 and can be controlled by either Vpu or Env. Since Vpu controls several independent functions, including CD4 degradation, our results suggest that some HIV-1 isolates may have evolved a mechanism to regulate Vpu activity without compromising their ability to efficiently replicate in the host cells.
A Conjoint Modeling Method of Horizontal and Vertical Product Differentiation Based on Transformation of Markets

Conjoint modeling for horizontal and vertical product differentiation took horizontal product differentiation and vertical product differentiation into account in a conjoint model. The aims of this paper were summing up and analyzing the existing conjoint modeling methods and putting forward a new conjoint modeling method. In this paper, the existing conjoint modeling methods were classified into two types, the conjoint modeling method of dividing consumers into large groups and that of applying econometric tools. The analyzing process of the former was so complex that its development was very constrained, while the latter was so dependent excessively for econometrics tools that it would be not helpful for the development of the economic theories of product differentiation. Thus, a new conjoint modeling method, the conjoint modeling method based on transformation of markets was put forward in this paper
Countering Terror Cells: Offence Versus Defence

ABSTRACT The analysis provides insights regarding the suitability of offensive versus defensive measures in countering a terror cell. It is shown that the optimal resource allocation is more offensive when the cell is aware of which targets have been protected, but does not distinguish between the values of different targets; than the case where it neither distinguishes between target values nor is the protection conspicuous. Also, the ability of the terror cell to inflict damage is least when it neither distinguishes between target values nor is the target protection conspicuous, and most when it shares the counter-terrorists’ target valuations and observes target protection. Hence, from the counter-terrorism (CT) point of view, there seems to be a rationale in making CT target valuations and target protection inconspicuous to the extent possible. The paper finally deals with the possibility of diverging target valuations from the CT standpoint and that of the terror cell and shows that if target protection is conspicuous to the cell and these are common knowledge, then the optimal CT allocation is at least as offensive as the case with identical valuation rankings.
Algoritmos de clustering basados en el concepto de líder

El objetivo principal de este proyecto final de carrera, que lleva por nombre “Algoritmos de clustering basados en el concepto de Lider”, consiste en obtener diferentes versiones de algoritmos de clustering modificando el algoritmo del Lider, asegurandose de que se conservan sus caracteristicas basicas y buenas propiedades, modificandolo con el objetivo de aumentar las buenas propiedades y ademas resolver algunos de los problemas que le son conocidos. Un algoritmo de clustering trata de formar grupos con las instancias que recibe como entrada buscando una cierta estructura en los datos. Se caracteriza por ser una tecnica no supervisada, es decir, no tiene en cuenta informacion de pertenencia previa de una instancia a un grupo. El algoritmo del Lider, en el cual se basa este proyecto, es un algoritmo clasico de clustering que realiza una sola pasada sobre las instancias de entrada. Sobre cada una comprueba su similitud con ciertas instancias “clave” ya pasadas, los lideres, que son los representantes de cada grupo de instancias creado hasta el momento. En base a los resultados de la comparacion se toma una decision: si la instancia es suficientemente similar a un lider, esta se incorpora al grupo de dicho lider. En cambio, si no es suficiente similar a ningun lider se crea un nuevo grupo con esa instancia como lider. El algoritmo basico del Lider tiene entre sus principales ventajas su rapidez de ejecucion y el no necesitar mas que una pasada sobre el conjunto de datos de entrada. Por el contrario, son varios los comportamientos que se podrian considerar defectuosos, como puede ser la dependencia del orden de los datos de entrada, asi como otros inconvenientes en el funcionamiento interno del algoritmo que le otorgan una serie de propiedades que no son deseables (o mas bien, le impiden contar con una serie de propiedades que se podrian considerar basicas y que son deseables para un algoritmo de este tipo). El algoritmo del Lider basa su funcionamiento en la comparacion de las nuevas instancias con los lideres. Para llevar a cabo estas comparaciones hay dos opciones, usar medidas de distancia o usar medidas de similitud, siendo esta ultima la elegida en el proyecto. El trabajo consta de dos ramas concretas: estudio teorico-reflexivo y desarrollo en pruebas del metodo para tratar de resolver sus inconvenientes por un lado, y, luego, estudio algoritmico del metodo con la intencion de mejorar su rendimiento dentro de los limites del lenguaje R, el elegido para el desarrollo del proyecto. Todo el proyecto se acompana de un estudio de articulos de diversos autores que otorgan un poco de luz a la hora de tomar ciertas decisiones, conocer experiencias similares o buscar nuevas soluciones a problemas que se nos plantean.
The Structure of Financial Resources for Corporate Training InThe Czech Republic

The aim of this contribution is to define the structure of financial resources for corporate training in the Czech Republic It is based on an analysis of the financial resources that companies in the Czech Republic set up for corporate training purposes. The sample set consisted of 607 companies. The companies were divided into four groupings according to their size: micro companies (1-9 employees); small companies (10-49 employees); medium-sized companies (50-249 employees); and large companies (250 or more employees). The hypothesis was put forward that 90% of all companies fund corporate training solely from their own resources.