Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring the perspectives of 10‐, 11‐, and 12‐year‐old primary school students on physical activity engagement—“'Cause you can't just be sitting at a desk all the time!”

BACKGROUND Research indicates that 91% of Canadian children are not engaging in enough physical activity (PA) to achieve health benefits. Physical education (PE) classes have been identified as a way to improve child health by facilitating engagement in movement-based activities. The daily physical activity (DPA) initiative was created with similar intentions and requires that students participate in at least 20 min of PA daily via PE classes and/or during instructional time for other subjects. Despite recommendations that 150 min of exercise/play be incurred weekly through either avenue, nearly half of Canadian schools fail to achieve this goal. The disconnect between PA-related school policies and low reported participation rates suggests that additional research is warranted. The purpose of this study was to explore the perspectives of primary students regarding the facilitators, barriers, and recommendations for PA engagement at their schools. METHODS Researchers conducted nine group interviews with 53 children aged 10-12, representing six primary schools in Northwestern Ontario using a semi-structured interview format. Sessions were analysed using inductive content analysis. RESULTS Participants discussed several facilitators of PA including enjoying activities (alleviating boredom and participating with others), accomplishment (skill building and enhanced self-image), and benefits in the classroom (thinking clearly and enhanced readiness to learn). Barriers to PA participation included school rules and culture (PA/PE restrictions, heavy workload, and "no work, no PA"), personal struggles (physical challenges and varied skill levels), and technology (being addictive and a replacement for being active). Recommendations for enhancing engagement that were outlined by the children centred around PE and daily physical activity (increase opportunities and involve students in planning/delivery) and recess-based themes (decrease focus on safety and make equipment more available). CONCLUSION These student perspectives and related recommendations may be beneficial for administrators and teachers in similar contexts who are seeking to enhance PA engagement among students with the goal of improving child health.
SQUALE – Software QUALity Enhancement

The Squale project was born from industrial effort to control software quality. Its goals are to re¿ne and enhance Qualixo Model, a software-metric based quality model already used by large companies in France (Air France-KLM, PSA Peugeot-Citroën) and to support the estimation of return on investment produced by software quality. Qualixo Model is a software quality model based on the aggregation of software metrics into higher level indicators called practices, criterias and factors. The coordination of Squale is carried out by Qualixo.
Networked Fusion Estimation With Bounded Noises

Most of time-varying systems in fusion estimation are generally modeled without bounded noises. In this paper, we study the distributed fusion estimation problem for networked time-varying systems with bounded noises, where the resource constraints (i.e., bandwidth or energy) and quantization effect are described by a unified model. A new local estimator with time-varying gain is designed by solving a class of convex optimization problems such that the square error of the estimator is bounded. When each local estimate is transmitted to the fusion center over communication networks, the selection probability criterion is derived such that the mean square error of the each compensating state estimate is bounded. Then, a convex optimization problem on the design of an optimal weighting fusion criterion is established in terms of linear matrix inequalities, which can be solved by standard software packages. Target tracking system with time-varying sampling period is given to show the effectiveness of the proposed method.
Symmetry Aware Evaluation of 3D Object Detection and Pose Estimation in Scenes of Many Parts in Bulk

While 3D object detection and pose estimation has been studied for a long time, its evaluation is not yet completely satisfactory. Indeed, existing datasets typically consist in numerous acquisitions of only a few scenes because of the tediousness of pose annotation, and existing evaluation protocols cannot handle properly objects with symmetries. This work aims at addressing those two points. We first present automatic techniques to produce fully annotated RGBD data of many object instances in arbitrary poses, with which we produce a dataset of thousands of independent scenes of bulk parts composed of both real and synthetic images. We then propose a consistent evaluation methodology suitable for any rigid object, regardless of its symmetries. We illustrate it with two reference object detection and pose estimation methods on different objects, and show that incorporating symmetry considerations into pose estimation methods themselves can lead to significant performance gains. The proposed dataset is available at http://rbregier.github. io/dataset2017.
Growth of Chitinophaga pinensis on Plant Cell Wall Glycans and Characterisation of a Glycoside Hydrolase Family 27 β-l-Arabinopyranosidase Implicated in Arabinogalactan Utilisation

The genome of the soil bacterium Chitinophaga pinensis encodes a diverse array of carbohydrate active enzymes, including nearly 200 representatives from over 50 glycoside hydrolase (GH) families, the enzymology of which is essentially unexplored. In light of this genetic potential, we reveal that C. pinensis has a broader saprophytic capacity to thrive on plant cell wall polysaccharides than previously reported, and specifically that secretion of β-l-arabinopyranosidase activity is induced during growth on arabinogalactan. We subsequently correlated this activity with the product of the Cpin_5740 gene, which encodes the sole member of glycoside hydrolase family 27 (GH27) in C. pinensis, CpArap27. Historically, GH27 is most commonly associated with α-d-galactopyranosidase and α-d-N-acetylgalactosaminidase activity. A new phylogenetic analysis of GH27 highlighted the likely importance of several conserved secondary structural features in determining substrate specificity and provides a predictive framework for identifying enzymes with the less common β-l-arabinopyranosidase activity.
Study on Language Rehabilitation for Aphasia

Objective: The aim is to update our clinical recommendations for evidence-based language rehabilitation of people with aphasia, based on a systematic review of the literature from 1999 to 2015. Data Sources: Articles referred to in this systematic review of the Medline and PubMed published in English language literatures were from 1998 to 2015. The terms used in the literature searches were aphasia and evidenced-based. Study Selection: The task force initially identified citations for 51 published articles. Of the 51 articles, 44 studies were selected after further detailed review. Six articles, which were not written in English, and one study related to laryngectomy rehabilitation interventions, were excluded from the study. This study referred to all the important and English literature in full. Results: Aphasia is the linguistic disability, which usually results from injuries to the dominant hemisphere of the brain. The rehabilitation of aphasia is until in the process of being debated and researched. Evidence-based medicine (EBM), EBM based on the clinical evidence, promotes the practice of combining the clinicians’ first-hand experience and the existing objective and scientific evidence encouraging making decisions based on both empirical evidence and the scientific evidence. Currently, EBM is being gradually implemented in the clinical practice as the aim of the development of modern medicine. Conclusions: At present, the research for the aphasia rehabilitation mainly focuses on the cognitive language rehabilitation and the intensive treatment and the precise treatment, etc. There is now sufficient information to support evidence-based protocols and implement empirically-supported treatments for linguistic disability after traumatic brain injury and stroke, which can be used to develop linguistic rehabilitation guidelines for patients with aphasia.
A User-Based Cross Domain Collaborative Filtering Algorithm Based on a Linear Decomposition Model

Sparsity is a tough problem in a single domain collaborative filtering (CF) recommendation system as it is difficult to compute the similarities among users accurately. Recently, cross domain CF is a new way to alleviate this difficulty. In this paper, we propose a user-based cross domain CF algorithm based on a linear decomposition model. We pour the items together and learn a linear decomposition model to explore the relationship between the total similarity and the local similarities of different domains. We first construct training samples by computing the similarities of any two users in different domains. Then, we solve a linear least square problem to obtain the decomposition coefficients. Finally, we compute the local similarity in the target domain using the decomposition model. Since we compute the similarity in the target domain with the help of rich ratings in other domains, this similarity would be expected to be more accurate than the measured similarity computed by the sparse ratings in the target domain. We conduct extensive experiments to show that the proposed algorithm is effective in addressing the data sparsity problem, as compared with many state-of-the-art CF methods.
Dysfunction of the Hypothalamic-Pituitary-Adrenal axis in HIV infection and disease

Abnormalities of the Hypothalamic-Pituitary-Adrenal (HPA) axis have been documented in HIV patients in the early as well as late stages of the infection and range from subtle subclinical disturbances to frank adrenal insufficiency. Potential etiologies of these disorders include opportunistic infections, neoplasms, drugs administered to treat infections, cytokine abnormalities associated with the HIV disease process and acquired alterations in tissue sensitivity to glucocorticoids. In this article, we present a concise review of HPA abnormalities in HIV infection and disease with regard to their etiology with emphasis on syndromes of hypersensitivity/resistance to glucocorticoids associated with antiviral medications and/or the HIV infection itself.
Microparticles from Patients Undergoing Percutaneous Coronary Intervention Impair Vasodilatation by Uncoupling Endothelial Nitric Oxide Synthase

Objectives: Percutaneous coronary interventions (PCIs) save countless acute myocardial infarction (AMI) patients. However, endothelial injury is still an inevitable complication. Circulating microparticles (MPs) play important roles in vascular dysfunction. Whether PCI affects function of MPs remains unclear. Methods: MPs were obtained from AMI patients (n = 38) both preoperatively and 24 h after PCI, and healthy subjects (n = 20). MPs origins were tested by flow cytometry. Rat thoracic aortas were incubated with MPs to determine the effects of MPs on phosphorylation of endothelial nitric oxide synthase (eNOS), caveolin-1 expression, eNOS association with heat shock protein 90 (Hsp90), generation of nitric oxide (NO) and superoxide anion (O2−), and endothelial-dependent vasodilatation. Results: Compared with healthy subjects, MP concentrations increased in AMI patients. Undergoing PCI had no further effect on MPs concentration, but it results in increased endothelial-derived MPs proportion and decreased platelet-derived MP ratio. MPs from AMI patients decreased eNOS phosphorylation at Ser1177, increased eNOS phosphorylation at T495 and caveolin-1 expression, decreased eNOS association with Hsp90, decreased NO production but increased (O2−) generation, damaged endothelial-dependent vasodilatation. All of these effects of MPs were strengthened by PCI. Conclusions: PCI further enhances the vascular injury effect of MPs. Circulating MPs may be a potential therapeutic target for patients undergoing PCI.
Gene expression profile analysis of human intervertebral disc degeneration

In this study, we used microarray analysis to investigate the biogenesis and progression of intervertebral disc degeneration. The gene expression profiles of 37 disc tissue samples obtained from patients with herniated discs and degenerative disc disease collected by the National Cancer Institute Cooperative Tissue Network were analyzed. Differentially expressed genes between more and less degenerated discs were identified by significant analysis of microarray. A total of 555 genes were significantly overexpressed in more degenerated discs with a false discovery rate of < 3%. Functional annotation showed that these genes were significantly associated with membrane-bound vesicles, calcium ion binding and extracellular matrix. Protein-protein interaction analysis showed that these genes, including previously reported genes such as fibronectin, COL2A1 and β-catenin, may play key roles in disc degeneration. Unsupervised clustering indicated that the widely used morphology-based Thompson grading system was only marginally associated with the molecular classification of intervertebral disc degeneration. These findings indicate that detailed, systematic gene analysis may be a useful way of studying the biology of intervertebral disc degeneration.
Absolute risk reductions for local recurrence after postoperative radiotherapy after sector resection for ductal carcinoma in situ of the breast.

PURPOSE Evaluate the effects of radiotherapy after sector resection for ductal carcinoma in situ of the breast (DCIS) in patient groups as defined by age, size of the lesion, focality, completeness of excision and mode of detection. PATIENTS AND METHODS A total of 1,067 women in Sweden were randomly assigned to either postoperative radiotherapy (RT) or control from 1987 to 1999, and 1,046 were followed for a mean of 8 years. The main outcome was new ipsilateral breast cancer events and distant metastasis-free survival analyzed according to intention to treat. RESULTS There were 64 ipsilateral events in the RT arm and 141 in the control group corresponding to a risk reduction of 16.0 percentage points at 10 years (95% CI, 10.3% to 21.6%) and a relative risk of 0.40 (95% CI, 0.30 to 0.54). There was no statistically significant difference in distant metastasis-free survival. There was an effect modification by age, yielding a low effect of RT in women younger than 50, but substantial protection in women older than 60 years. The age effect was not confounded by focality, lesion size, completeness of excision, or detection mode. There was no group as defined by our stratification variables that had a low risk without radiotherapy. CONCLUSION Our results indicate that younger women have a low protective effect of conventional RT after sector resection. Older women benefit substantially. We caution that the age effect was seen in a subgroup analysis. Further search with conventional clinical variables for a low risk group that does not need RT does not seem fruitful.
Respiratory Mites (Orthohalarachne diminuata) and β-hemolytic Streptococci-Associated Bronchopneumonia Outbreak in South American Fur Seal Pups (Arctocephalus australis)

Abstract: Although mites of the Orthohalarachne genus are common parasites of otariids, their role as agents of disease and in causing population-level mortality is unknown. In the austral summer of 2016, there was an increase in mortality among South American fur seal (Arctocephalus australis) pups at Guafo Island, Northern Chilean Patagonia. Pups found dead or terminally ill had moderate to marked, multifocal, mucopurulent bronchopneumonia associated with large numbers of respiratory mites (Orthohalarachne diminuata) and rare Gram-positive cocci. In lung areas less affected by bronchopneumonia, acute interstitial pneumonia with marked congestion and scant hemorrhage was evident. Bacteria from pups dying of bronchopneumonia were isolated and identified as Streptococcus marimammalium and Streptococcus canis. Respiratory mites obstructed airflow, disrupted airway epithelial lining, and likely facilitated the proliferation of pathogenic β-hemolytic streptococci, leading to severe bronchopneumonia and death of fur seal pups. An abrupt increase in sea surface temperature in Guafo Island corresponded to the timing of the bronchopneumonia outbreak. The potential role of environmental factors in the fur seal pup mortality warrants further study.
The role of infarct transmural extent in infarct extension: A computational study

Infarct extension, a process involving progressive extension of the infarct zone (IZ) into the normally perfused border zone (BZ), leads to continuous degradation of the myocardial function and adverse remodelling. Despite carrying a high risk of mortality, detailed understanding of the mechanisms leading to BZ hypoxia and infarct extension remains unexplored. In the present study, we developed a 3D truncated ellipsoidal left ventricular model incorporating realistic electromechanical properties and fibre orientation to examine the mechanical interaction among the remote, infarct and BZs in the presence of varying infarct transmural extent (TME). Localized highly abnormal systolic fibre stress was observed at the BZ, owing to the simultaneous presence of moderately increased stiffness and fibre strain at this region, caused by the mechanical tethering effect imposed by the overstretched IZ. Our simulations also demonstrated the greatest tethering effect and stress in BZ regions with fibre direction tangential to the BZ–remote zone boundary. This can be explained by the lower stiffness in the cross‐fibre direction, which gave rise to a greater stretching of the IZ in this direction. The average fibre strain of the IZ, as well as the maximum stress in the sub‐endocardial layer, increased steeply from 10% to 50% infarct TME, and slower thereafter. Based on our stress–strain loop analysis, we found impairment in the myocardial energy efficiency and elevated energy expenditure with increasing infarct TME, which we believe to place the BZ at further risk of hypoxia. Copyright © 2016 John Wiley & Sons, Ltd.
Effect of Ca2+ on the Steady-State and Time-Resolved Emission Properties of the Genetically Encoded Fluorescent Sensor CatchER

We previously designed a calcium sensor CatchER (a GFP-based Calcium sensor for detecting high concentrations in the high calcium concentration environment such as ER) with a capability for monitoring calcium ion responses in various types of cells. Calcium binding to CatchER induces the ratiometric changes in the absorption spectra, as well as an increase in fluorescence emission at 510 nm upon excitation at both 395 and 488 nm. Here, we have applied the combination of the steady-state and time-resolved optical methods and Hydrogen/Deuterium isotope exchange to understand the origin of such calcium-induced optical property changes of CatchER. We first demonstrated that calcium binding results in a 44% mean fluorescence lifetime increase of the indirectly excited anionic chromophore. Thus, CatchER is the first protein-based calcium indicator with the single fluorescent moiety to show the direct correlation between the lifetime and calcium binding. Calcium exhibits a strong inhibition on the excited-state proton transfer nonadiabatic geminate recombination in protic (vs deuteric) medium. Analysis of CatchER crystal structures and the MD simulations reveal the proton transfer mechanism in which the disrupted proton migration path in CatchER is rescued by calcium binding. Our finding provides important insights for a strategy to design calcium sensors and suggests that CatchER could be a useful probe for FLIM imaging of calcium in situ.
Resource-Driven Mission-Phasing Techniques for Constrained Agents in Stochastic Environments

Resource constraints restrict the set of actions that an agent can take, such that the agent might not be able to perform all its desired tasks. Computational time limitations restrict the number of states that an agent can model and reason over, such that the agent might not be able to formulate a policy that can respond to all possible eventualities. This work argues that, in either situation, one effective way of improving the agent's performance is to adopt a phasing strategy. Resource-constrained agents can choose to reconfigure resources and switch action sets for handling upcoming events better when moving from phase to phase; time-limited agents can choose to focus computation on high-value phases and to exploit additional computation time during the execution of earlier phases to improve solutions for future phases. This dissertation consists of two parts, corresponding to the aforementioned resource constraints and computational time limitations. The first part of the dissertation focuses on the development of automated resource-driven mission-phasing techniques for agents operating in resource-constrained environments. We designed a suite of algorithms which not only can find solutions to optimize the use of predefined phase-switching points, but can also automatically determine where to establish such points, accounting for the cost of creating them, in complex stochastic environments. By formulating the coupled problems of mission decomposition, resource configuration, and policy formulation into a single compact mathematical formulation, the presented algorithms can effectively exploit problem structure and often considerably reduce computational cost for finding exact solutions. The second part of this dissertation is the design of computation-driven mission-phasing techniques for time-critical systems. We developed a new deliberation scheduling approach, which can simultaneously solve the coupled problems of deciding both when to deliberate given its cost, and which phase decision procedures to execute during deliberation intervals. Meanwhile, we designed a heuristic search method to effectively utilize the allocated time within each phase. As illustrated in analytical and experimental results, the computation-driven mission-phasing techniques, which extend problem decomposition techniques with the across-phase deliberation scheduling and inner-phase heuristic search methods mentioned above, can help an agent judiciously emphasize high-value portions of a large problem, while paying less attention to others, to generate a better policy within its time limit.
Stem cell-compatible eumelanin biointerface fabricated by chemically controlled solid state polymerization

Relying on the water-dependent hybrid conductor properties of eumelanin biopolymers, a structurally controlled melanin thin film that can be reversibly switched-on and off by hydration–dehydration cycles and used as a biocompatible platform for stem cell growth and differentiation up to 11 days is reported. A key feature of the new eumelanin-based bioelectronic interface is its remarkable structural regularity and integrity, as the result of an ad hoc fabrication protocol involving ammonia-induced solid state polymerization (AISSP) technology of a 5,6-dihydroxyindole thin film. The AISSP technology is operationally simple and versatile, enabling the preparation of device-quality thin films (AFM and MALDI-MS evidence) on various substrates with efficient chemical control over molecular complexity. Overall the results of this study pave the way for the implementation of tailored eumelanin thin films for bioelectronic devices, e.g., in organic electrochemical transistors (OECTs).