The variability of cardiopulmonary adaptation to pregnancy at rest and during exercise.

OBJECTIVE To examine the cardiopulmonary adaptation to normal pregnancy in sitting women during rest and bicycle exercise. DESIGN A longitudinal study beginning early in pregnancy and ending 8-12 months after delivery. SETTING University Hospital, Zurich, Switzerland. SUBJECTS 20 women were monitored every second week during pregnancy from 8 to 14 weeks gestation, twice in the puerperium and twice 6-8 weeks and twice 8-12 months after delivery. All the women finished the study, but not all of them participated in every visit. MEASUREMENTS AND MAIN RESULTS The results obtained 8-12 months after delivery are considered the non-pregnant data and are presented first so that any change in pregnancy will be more obvious. Values given below refer to the median except when stated otherwise. At rest: 1. Oxygen consumption increased significantly from a median of 182 ml/min in the non-pregnant state to 256 ml/min by 8-11 weeks gestation, and peaked at 300 ml/min at 32 weeks. At 6-8 weeks after delivery the value was 225 ml/min. 2. Oxygen consumption per kg increased significantly from 3.0 ml/min in the non-pregnant state to 4.3 ml/min by 8-11 weeks gestation and peaked at 5.0 ml/min soon after delivery. At 6-8 weeks after delivery the value was 3.4 ml/min. 3. Carbon dioxide production generally showed changes similar to those of oxygen consumption. 4. Respiratory quotient did not show any significant changes. 5. Ventilation increased from a median of 9.4 l/min in the non-pregnant state to 10.5 l/min by 8-11 weeks and then slowly increased to 12.6 l/min in late pregnancy. 6. Respiratory rate did not change significantly. 7. Tidal volume showed a median of 563 ml in the non-pregnant women and rose significantly to 632 ml in early pregnancy, peaking at 715 ml in late pregnancy. 8. Alveolar ventilation increased significantly from a non-pregnant value of 3.4 l/min to 6.2 l/min in early pregnancy, peaking at 6.7 l/min at term; 6-8 weeks after delivery the value was 4.5 l/min. 9. Ventilation equivalent for oxygen fell significantly from the median non-pregnant value of 52 to 42 in early pregnancy and remained at that level until 6-8 weeks after delivery when it was 44. 10. Ventilation equivalent for carbon dioxide showed similar changes to those for oxygen. 11. Alveolar carbon dioxide tension fell significantly from a median non-pregnant level of 4.6 kPa (34 mmHg) to 4.0 kPa (30 mmHg) in early pregnancy. It began to increase in the puerperium and was 4.3 kPa (33 mmHg) 6-8 weeks after delivery. 12. Mixed venous carbon dioxide tension fell significantly from a median of 5.9 kPa (44 mmHg) to 5.2 kPa (39 mmHg) during pregnancy. 13. Transcutaneous carbon dioxide tension decreased significantly in early pregnancy from 8.8 kPa (66 mmHg) in the non-pregnant women, and from 20 weeks gestation remained at 6.9 kPa (52 mmHg). 14. Transcutaneous oxygen tension showed a non-significant increase from 10.0 kPa (75 mmHg) in the non-pregnant women to 11.1 kPa (83 mmHg) during pregnancy. 15. Cardiac frequency increased gradually from a non-pregnant median of 80 b.p.m. to about 90 b.p.m. in the last 2 months of pregnancy. In the puerperium the median was 75 b.p.m. 16. Cardiac output increased significantly by almost 50% from the non-pregnancy level to that at 8-11 weeks gestation. 17. Cardiac output per kg also increased significantly by 50% from the non-pregnant level to that at 8-11 weeks gestation. From mid-pregnancy there was a gradual fall until delivery. 18. Stroke volume increased significantly from a median of 31 ml in the non-pregnant state to 51 ml in early pregnancy, and remained at this level until delivery. In the puerperium the stroke volume was 63 ml. 19. Oxygen pulse increased significantly from a median of 2.2 ml in the non-pregnant women to 3.1 ml in early pregnancy and remained at that level. 20. Individual curves. (ABSTRACT TRUNCATED AT 400 WORDS)