Miracle-dz/UniFAR-FTUs huggingface dataset:
Complete modification rescheduling method for semiconductor wafer fabs

To solve rescheduling problem for semiconductor wafer fabs effectively,a swarmintelligence-based complete modification rescheduling method was proposed.Firstly,the Swarm-Intelligence-based Rescheduling Model(SIRM) was presented.Based on SIRM,the Complete Modification Rescheduling Algorithm(CMRA) was proposed.Finally,a simulation model based on an actual wafer fab was built to compare CMRA with the existing scheduling method in the fab.Simulation results showed that CMRA was prior to the existing method of the fab on movement,Work in Process(WIP)move speed and operation due date with better performance under uncertain chip manufacturing environment.At present,the proposed method has been applied to the actual wafer fab with better performance.
DONALD: a workbench for interactive design space exploration and sizing of analog circuits

Presents the program DONALD. DONALD constitutes a new approach to the use of numerical computation in circuit sizing. The program is able to numerically invert an analytic design model of an analog circuit in any arbitrary direction. It is therefore possible to answer with DONALD both design questions: analysis questions, as well as technology questions. To accomplish this, the program uses a new, heuristic algorithm for detection of minimal clusternodes in bipartite graphs. A graphical, mouse oriented user interface allows the user to make strategic and optimum moves through a circuit's design space. <<ETX>>
Time-Limited, Structured Youth Mentoring and Adolescent Problem Behaviors

Youth mentoring can have a profound impact on the lives of high-risk youth. This study presents the Campus Corps program, a time-limited (12-week), structured mentoring program for high-risk youth (ages 11–18), and results from a quasi-experimental pilot evaluation. Baseline and post-intervention problem behavior data from 315 offending youth were used in multiple regression analyses. After accounting for baseline group differences, pre-intervention scores, and demographic covariates, Campus Corps participants (n = 187, 63.1% male) reported less engagement in problem behavior, lower acceptance of problem behavior, and a greater sense of autonomy from marijuana use post-intervention than participants in the comparison condition (n = 128, 66.4% male). Conversely, post-intervention group differences were not observed for peer refusal skills or autonomy from alcohol use. A description of the Campus Corps program design and supplemental preliminary findings contribute to the growing knowledge base of youth mentoring program designs and outcomes.
Hepatitis C Virus Is Released via a Noncanonical Secretory Route

ABSTRACT We analyzed hepatitis C virus (HCV) morphogenesis using viral genomes encoding a mCherry-tagged E1 glycoprotein. HCV-E1-mCherry polyprotein expression, intracellular localization, and replication kinetics were comparable to those of untagged HCV, and E1-mCherry-tagged viral particles were assembled and released into cell culture supernatants. Expression and localization of structural E1 and nonstructural NS5A followed a temporospatial pattern with a succinct decrease in the number of replication complexes and the appearance of E1-mCherry punctae. Interaction of the structural proteins E1, Core, and E2 increased at E1-mCherry punctae in a time-dependent manner, indicating that E1-mCherry punctae represent assembled or assembling virions. E1-mCherry did not colocalize with Golgi markers. Furthermore, the bulk of viral glycoproteins within released particles revealed an EndoH-sensitive glycosylation pattern, indicating an absence of viral glycoprotein processing by the Golgi apparatus. In contrast, HCV-E1-mCherry trafficked with Rab9-positive compartments and inhibition of endosomes specifically suppressed HCV release. Our data suggest that assembled HCV particles are released via a noncanonical secretory route involving the endosomal compartment. IMPORTANCE The goal of this study was to shed light on the poorly understood trafficking and release routes of hepatitis C virus (HCV). For this, we generated novel HCV genomes which resulted in the production of fluorescently labeled viral particles. We used live-cell microscopy and other imaging techniques to follow up on the temporal dynamics of virus particle formation and trafficking in HCV-expressing liver cells. While viral particles and viral structural protein were found in endosomal compartments, no overlap of Golgi structures could be observed. Furthermore, biochemical and inhibitor-based experiments support a HCV release route which is distinguishable from canonical Golgi-mediated secretion. Since viruses hijack cellular pathways to generate viral progeny, our results point toward the possible existence of a not-yet-described cellular secretion route.
Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

GPR7 and GPR8 are orphan G protein-coupled receptors that are highly similar to each other. These receptors are expressed predominantly in brain, suggesting roles in central nervous system function. We have purified an endogenous peptide ligand for GPR7 from bovine hypothalamus extracts. This peptide, termed neuropeptide B (NPB), has a C-6-brominated tryptophan residue at the N terminus. It binds and activates human GPR7 or GPR8 with median effective concentrations (EC50) of 0.23 nM and 15.8 nM, respectively. In situ hybridization shows distinct localizations of the prepro-NPB mRNA in mouse brain, i.e., in paraventricular hypothalamic nucleus, hippocampus, and several nuclei in midbrain and brainstem. Intracerebroventricular (i.c.v.) injection of NPB in mice induces hyperphagia during the first 2 h, followed by hypophagia. Intracerebroventricular injection of NPB produces analgesia to s.c. formalin injection in rats. Through EST database searches, we identified a putative paralogous peptide. This peptide, termed neuropeptide W (NPW), also has an N-terminal tryptophan residue. Synthetic human NPW binds and activates human GPR7 or GPR8 with EC50 values of 0.56 nM and 0.51 nM, respectively. The expression of NPW mRNA in mouse brain is confined to specific nuclei in midbrain and brainstem. These findings suggest diverse physiological functions of NPB and NPW in the central nervous system, acting as endogenous ligands on GPR7 and/or GPR8.
Preparing NERSC users for Cori, a Cray XC40 system with Intel many integrated cores

The newest NERSC supercomputer Cori is a Cray XC40 system consisting of 2,388 Intel Xeon Haswell nodes and 9,688 Intel Xeon‐Phi “Knights Landing” (KNL) nodes. Compared to the Xeon‐based clusters NERSC users are familiar with, optimal performance on Cori requires consideration of KNL mode settings; process, thread, and memory affinity; fine‐grain parallelization; vectorization; and use of the high‐bandwidth MCDRAM memory. This paper describes our efforts preparing NERSC users for KNL through the NERSC Exascale Science Application Program, Web documentation, and user training. We discuss how we configured the Cori system for usability and productivity, addressing programming concerns, batch system configurations, and default KNL cluster and memory modes. System usage data, job completion analysis, programming and running jobs issues, and a few successful user stories on KNL are presented.
Long-Term Low-Dose Treatment With Reserpine of Cholesterol-Fed Rabbits Reduces Cholesterol in Plasma, Non-High Density Lipoproteins and Arterial Walls

The effects of long-term low-dose treatment with reserpine on plasma lipoproteins and arterial cholesterol were determined in cholesterol-fed rabbits. Hepatic low-density lipoprotein (LDL) receptors; uptake of LDL by liver, heart, and kidneys; plasma fibrinogen; blood pressure; and heart rate were also determined. Reserpine at 43 &mgr;g/kg · d was continuously infused subcutaneously via implanted minipumps for 6 weeks into conscious unrestrained male New Zealand White rabbits (n = 5) fed a 0.2% cholesterol-enriched diet. Compared with controls, reserpine (n = 4) significantly reduced the elevated levels of plasma total cholesterol and esterified and unesterified cholesterol throughout the study, and at 6 weeks of treatment these reductions were 42, 41, and 49%, respectively. The increased cholesterol in the aortic walls (n = 5) produced by the atherogenic diet was reduced by 73% (p < 0.004) and 125I-tyramine cellobiose-labeled LDL by 67 to 86% (0.05 < p <0.004), respectively. The aortic intimal-medial thickness ratio was reduced by 70%. The decrease in elevated plasma total cholesterol was mainly due to cholesterol reductions in both LDL (41%) and non–high density lipoprotein (HDL) of density < 1.019 g/ml (51%). HDL cholesterol and triglyceride levels were unchanged. Reserpine had no significant effects on the clearance of 125I-tyramine cellobiose-LDL from plasma and there was a trend towards an increase in hepatic LDL receptor expression. Heart rate was decreased by 28%. There were no significant effects on blood pressure, liver and heart lipids, hematocrit, or plasma fibrinogen. The results suggest that treatment of cholesterol-fed rabbits with reserpine at a low dose over a long period prevents increases in plasma atherogenic lipoproteins. Reserpine decreases the cholesterol in aortic walls and the intima-media thickness ratio. This anti-atherosclerotic effect of reserpine may have therapeutic implication.
PM359. A prospective cohort study for metabolic measures during antipsychotic treatments in patients with schizophrenia and schizoaffective disorder: A cross-sectional analysis of baseline data

s | 31 yearly family income were included as covariates in model 1 and the child’s IQ was added as a covariate in model 2. Results: Children who were breastfed had higher listening (p = 0.048), speaking (p < 0.001), reading (p = 0.002), writing (p = 0.002), spelling (p = 0.001), mathematical calculation (p = 0.002), and learning quotient (p < 0.001) scores in the LDES in model 1. When adding the child’s IQ as a covariate, the speaking (p = 0.013), spelling (p = 0.041), and learning quotient (p = 0.042) still remained significant Conclusion: The results suggest that breastfeeding has a protective effect on learning disabilities in school-aged children.
Streptomyces nobilis C51 Suppresses Gray Mold Caused by Botrytis cinerea in Tomato

This study sought to develop a biological control agent against gray mold disease caused by Botrytis cinerea in tomato using a strain of Streptomyces, which showed significant antagonistic activity against B. cinerea. Such strain (C51) was screened by dual culture method from a total of 78 actinomycetes and was identified as Streptomyces nobilis by morphological, biochemical and molecular analysis. The influence of different environmental conditions, such as temperature degree, pH range and medium type on the expression of the antifungal activity was thoroughly examined. The metabolites involved in the antagonistic action of C51 strain showed to be produced independently by the presence of B. cinerea. We also found that the culture filtrate of C51 potently inhibited the mycelial growth of B. cinerea, and morphological changes such as hyphal swelling and Original Research Article Jiang et al.; BMRJ, 16(6): 1-13, 2016; Article no.BMRJ. 27284 2 abnormal shapes were observed using culture filtrates. The antifungal activity of the culture broth was stable across a broad range of temperatures (28-121°C) and pH (pH 2-12), suggesting a wide range of applications of Streptomyces nobilis C51. The results of greenhouse test showed that Streptomyces nobilis C51 had the same disease inhibition effect as well as azoxystrobin against B. cinerea. The current observations could support the application of Streptomyces nobilis C51 as a promise biocontrol agent.
EARP-1 - an evolvable analog research platform

This paper describes a new evolvable analog hardware research platform currently under development. This platform, called EARP-1, differs significantly from previous efforts, in that it has a coarse-grained, signal-flow architecture oriented towards implementing state-variable filters and control systems. This platform has been implemented in SSI CMOS digital and analog integrated circuits on several printed circuit board cards, and is controlled by a Windows/spl trade/-based PC.
HLA class II DPB1 and DRB1 polymorphisms associated with genetic susceptibility to beryllium toxicity

Objectives Chronic beryllium disease (CBD) is a hypersensitivity granulomatous pulmonary disease caused by exposure to the metal beryllium (Be2+). Our objective was to extend current knowledge of the genetics of beryllium disease by examining all HLA-DPB1 and HLA-DPR1 gene polymorphisms and the interactions between them. Methods DNA-based typing of HLA-DPB1 and HLA-DRB1 loci at the allele level was performed on 65 CBD, 44 beryllium sensitised (BeS) but without CBD and 288 non-affected, beryllium exposed controls. Results The DPβE69 residue regardless of zygosity, but particularly if present on non-*0201 alleles, was of primary importance for the development of CBD and BeS, while other negatively charged residues DPβDE55, 56 and DPβDE84, 85 incrementally increased, although not independently, the risk. The DPβE69 positive alleles with charge −7 or −9 were associated with both CBD and BeS. The polymorphic residues DPβE69, DPβDE55, 56 and DPβDE84, 85 were responsible for the −9 charge and the first two residues for the −7 charge. Conclusions In the absence of DPβE69, DRβE71 is a risk factor for CBD and BeS. DPβE69 and DRβE71 are adjacent to other amino acids that are also negatively charged, suggesting that the positively charged Be2+ modifies the local environment of the epitopes in a way that promotes interactions between peptides and T cells and results in CBD. Finally, the protective effect of the DPB1*0201 positive haplotype may involve particular polymorphisms outside of the DPB1 gene.
Improving multi-view human action recognition with spatial-temporal pooling and view shifting techniques

This paper presents a solution to improve performance of human action recognition from multiple camera views. For each camera view, we started by investigating a bag of words model that consists of STIP features to capture motion, a random forest for feature quantization and a SVM for action classification as baseline. However, to avoid background effect, we take STIP features only in the moving regions detected by background subtraction technique. Then, as some actions are very similar (interclass similarity), they discriminate against each others by some minor motions of body part (hand or foot) or/and by the order of movement during the action, we adopt a spatial-temporal pooling strategy of STIP features to take this difference into account. Finally we propose a strategy of shifting views in testing phase to deal with difference of camera viewpoints from training phase. The result from each view will be combined by late fusion. The proposed method has been evaluated on a benchmark multi-view dataset WVU. Experimental results show that this method achieves 92.28% of accuracy, that outperforms the baseline by 23.92%. It is evenly better than a method using advanced convolution neural network by 2.28%.
Greater age-related decline in markers of physical, mental and cognitive health among Israeli older adults exposed to lifetime cumulative adversity

Objectives: This longitudinal investigation addressed whether and how lifetime cumulative adversity and depressive symptoms moderated age-related decline in markers of physical, mental, and cognitive health.Method: 1248 older adults (mean age = 62 at Wave 1) who completed the first two waves of the Israeli component of the Survey of Health, Ageing and Retirement in Europe (SHARE-Israel) reported on exposure to potentially traumatic life events, depressive symptoms, and three outcomes – disability, quality of life, and cognitive markers.Results: Age was related to greater functional decline in outcome measures across the two waves (i.e., increase in disability and decrease in quality of life and cognitive functioning). This age-related decline became stronger as lifetime adversity increased. A three-way interaction showed that the greatest age-related functional decline in outcome measures was especially salient among those with high level of lifetime adversity and high level of depressive symptoms.Conclusion: Lifetime cumulative adversity is associated with a more noticeable process of age-related dysfunction across various markers of health. Although the majority of older adults are resilient to lifetime adversity, prevention and intervention programs should be aimed at mitigating the pronounced senescence observed when adversity accumulated to a large degree, and especially when it is accompanied with high level of distress.
Economic Dispatch Using the Reduced Hessian

In general, second derivative or Hessian based optimization methods have a much higher convergence efficiency than those techniques based on the gradient of the objective function. Unfortunately, for problems such as economic dispatch where the generation cost has to be minimized subject to the load flow equality constraints, the reduced Hessian with respect to the controllable variables is, in general, non-sparse and requires extensive computations to evaluate. In the literature this obstacle has been bypassed either by approximating the reduced Hessian or by handling equality constraints through penalty functions added to the cost. This last approach greatly simplifies the computation of the Hessian which also becomes sparse, but it has the drawback of requiring adjustments of the penalty functions weighting coefficients, a non-systematic step which may lead to numerical difficulties and to sub-optimal solutions.
Experimental evaluation of ROS compatible SLAM algorithms for RGB-D sensors

The recent adoption of the Robot Operating System (ROS) as a software standard in robotics has contributed to novel solutions for several problems on the area. One such problem is known as Simultaneous Localization and Mapping (SLAM), for which a number of algorithms from different classes are available as ROS packages ready to be used on any compatible robot. Considering that there is often a need to evaluate and choose an appropriate solution in any robotics application, this work presents an experimental evaluation of five SLAM algorithms usable on RGB-D sensors, namely, Gmapping, Hector SLAM, ORB SLAM, ORB SLAM 2 and RTAB-Map. The algorithms are assessed on data depicting realistic operation scenarios according to established criteria enumerated to emphasize practical aspects of the selected systems. The experiences reported on this work should provide insight for roboticists seeking a SLAM solution for indoor applications.
Anti‐Microbial Activity and Composition of Manuka and Portobello Honey

Recently renewed interest in the therapeutic properties of honey has led to the search for new antimicrobial honeys. This study was undertaken to assess the antimicrobial activity and composition of a locally produced Portobello honey (PBH) on three bacteria known to infect wounds. Manuka honey (MH) was used for comparative purposes. Broth culture and agar disc diffusion assays were used to investigate the antimicrobial properties of honey. The honeys were tested at four concentrations: 75%, 50%, 10% and 1% (v/v) and compared with an untreated control. The composition of honey was determined by measuring: polyphenol content by Folin Ciocalteau method, antioxidant capacity by ferric ion reducing power assay, hydrogen peroxide (H2O2) by catalase test, pH and sugar content by pH strips and refractometer, respectively. Both honeys at 75% and 50% inhibited the majority of the three bacteria tested. 10% PBH exhibited antimicrobial activity to the lesser extent than 10% MH. The difference was very significant (p ≤ 0.001). Both honeys were acidic with pH 4, and both produced H2O2. The sugar content of PBH was higher than MH, but the difference was not significant. The MH had significantly higher levels of the polyphenols and antioxidant activity than PBH. Copyright © 2012 John Wiley & Sons, Ltd.
FACTORS AFFECTING THE ELABORATION BY CLOSTRIDIUM HISTOLYTICUM OF PROTEINASES CAPABLE OF DEBRIDING THIRD DEGREE BURN ESCHARS ON GUINEA PIGS

Berman, Sanford (Walter Reed Army Institute of Research, Washington, D. C.), Joseph P. Lowenthal, Marion E. Webster, Patricia L. Altieri, and Raymond B. Gochenour. Factors affecting the elaboration by Clostridium histolyticum of proteinases capable of debriding third degree burn eschars on guinea pigs. J. Bacteriol. 82:582–588. 1961. —A comparison of three strains of Clostridium histolyticum grown in two different media indicated that the H-4 strain produced the greatest yield of enzyme(s) capable of debriding third degree burn eschars on guinea pigs. Some of the nutritional and physiological factors affecting the elaboration of enzymes by this strain have been investigated. Maximal yields have been obtained after incubation for 14 to 16 hr at 30 C in a medium consisting of 5% proteose-peptone, 1.5% trypticase soy broth, and vitamins; pH 7.5. A medium consisting of 2% proteose-peptone and 2% Casamino acids yields somewhat lower enzyme titers, but has the compensating advantage of being less costly and may be more amenable to purification and concentration procedures because of its reduced precipitable nitrogen content.
Effect of a Nonsedative Dose of Propofol on Memory for Aversively Loaded Information in Rats

Background The effects of propofol on memory for aversive information are not well determined. The authors evaluated the effects of a minimal nonsedative dose of propofol or midazolam on memory in rats, using an apparatus composed of two compartments: a large bright anxiogenic one and a small dark neutral one. Methods Groups of rat received propofol (9 mg/kg, intraperitoneally) or midazolam (3 mg/kg). Anxiety was assessed in rats placed in the anxiogenic compartment as the time before the animals entered the neutral compartment. Memory for an aversive event was assessed in rats placed in the anxiogenic compartment as the time to enter the neutral one where they previously experienced foot shocks (fear conditioning). To assess the memory for a nonaversive event, rats were placed in the neutral compartment with no shocks (preexposure). The following day, rats were placed in it and they experienced foot shocks. As a result of the preexposure, rats exhibit less fear to enter it. Results Propofol and midazolam increased the time to enter the neutral compartment. Propofol or midazolam was given to rats before experiencing foot shocks in the neutral compartment. When later tested, the time to enter it was decreased. Propofol or midazolam was given to rats before the preexposure to the neutral compartment. When later tested, the latency to enter it was not modified by the preexposure. Conclusions Propofol and midazolam impaired memory for aversive and for nonaversive experiences at equianxiolytic doses that do not produce locomotor impairment in rats.
Time Severity for AKI Time Severity for Glucose Severity for CKD Stage I Time Severity for Diabetes Time

Electronic Medical Records (EMR) are the most fundamental resources used in healthcare data analytics. Since people visit hospital more frequently when they feel sick and doctors prescribe lab examinations when they feel necessary, we argue that there could be a strong bias in EMR observations compared with the hidden conditions of patients. Directly using such EMR for analytical tasks without considering the bias may lead to misinterpretation. To this end, we propose a general method to resolve the bias by transforming EMR to regular patient hidden condition series using a Hidden Markov Model (HMM) variant. Compared with the biased EMR series with irregular time stamps, the unbiased regular time series is much easier to be processed by most analytical models and yields better results. Extensive experimental results demonstrate that our bias resolving method imputes missing data more accurately than baselines and improves the performance of the state-of-the-art methods on typical medical data analytics.