Miracle-dz/UniFAR-FTUs huggingface dataset:
2016 Ieee International Conference on Big Data (big Data) an Integrated Assessment Approach to Different Collaborative Filtering Algorithms

Collaborative Filtering (CF) Recommendation System is a prominent technology which is widely online. Large variety of available CF algorithms and the multitude of their possible parameters have a huge impact on quality of the outcome on E-Commerce. Unfortunately, the literature on CF recommender system evaluation presents different evaluation metrics at different situation and could not provide any suggestion about the best. At the same time, it is a fact to accept that the accuracy measure should be different for each CF algorithm and depends upon the classification accuracy of that particular algorithm. As an initiative to address this problem in the present research paper, predictive accuracy metrics, classification accuracy metrics and rank accuracy metrics are considered as the classification accuracy metrics to know the overall competence for significant features of the chosen CF algorithms. At this juncture, normalization, a distinctive evaluation methodology, has been adopted to accomplish unique evaluation results of recommender systems. In this research paper, different accuracy metrics assessment would be brought into a common scale by taking into consideration of normalization process to evaluate metrics of the CF algorithms. A comprehensive comparative analysis is carried out and tabulated.
The communication complexity of coalition formation among autonomous agents

It is self-evident that in numerous Multiagent settings, selfish agents stand to benefit from cooperating by forming coalitions. Nevertheless, negotiating a stable distribution of the payoff among agents may prove challenging. The issue of coalition formation has been investigated extensively in the field of cooperative n-person game theory, but until recently little attention has been given to the complications that arise when the players are software agents. The bounded rationality of such agents has motivated researchers to study the computational complexity of the aforementioned problems.In this paper, we examine the communication complexity of coalition formation, in an environment whore each of the n agents knows only its own initial resources and utility function. Specifically, we give a tight Θ(n) bound on the communication complexity of the following solution concepts in unrestricted games: Shapley value, the nucleolus and the modified nucleolus, equal excess theory, and the core. Moreover, we show that in some intuitively appealing restricted games the communication complexity is constant, suggesting that it is possible to achieve sublinear complexity by constraining the environment or choosing a suitable solution concept.
Fine-grain dynamic instruction placement for L0 scratch-pad memory

We present a fine-grain dynamic instruction placement algorithm for small L0 scratch-pad memories (SPMs), whose unit of transfer can be an individual instruction. Our algorithm captures a large fraction of instruction reuse missed by coarse-grain placement algorithms whose unit of transfer is restricted to loops or functions within the capacity of SPMs. Evaluation of L0 SPMs with our fine-grain algorithm in 17 applications shows that the energy consumed by instruction storage hierarchy is reduced by 38% and 31% compared to that of L0 instruction caches and L0 SPMs with an ideal coarse-grain algorithm, respectively.
LIMSI’s experiments in domain adaptation for IWSLT11

LIMSI took part in the IWSLT 2011 TED task in the MT track for English to French using the in-house n-code system, which implements the n-gram based approach to Machine Translation. This framework not only allows to achieve state-of-the-art results for this language pair, but is also appealing due to its conceptual simplicity and its use of well understood statistical language models. Using this approach, we compare several ways to adapt our existing systems and resources to the TED task with mixture of language models and try to provide an analysis of the modest gains obtained by training a log linear combination of in- and out-of-domain models.
Illness during pregnancy and bacterial vaginosis are associated with in-utero HIV-1 transmission

HIV-1 transmission in utero accounts for 20–30% of vertical transmission events in breast-feeding populations. In a prospective study of 463 HIV-1-infected mothers and infants, illness during pregnancy was associated with 2.6-fold increased risk of in-utero HIV-1 transmission [95% confidence interval (CI) 1.2–5.8] and bacterial vaginosis with a three-fold increase (95% CI 1.0–7.0) after adjusting for maternal HIV-1 viral load. Interventions targeting these novel risk factors could lead to more effective prevention of transmission during pregnancy.
Analysis of Directional Logging Tools in Anisotropic and Multieccentric Cylindrically-Layered Earth Formations

We develop a pseudoanalytical method for the analysis of directional resistivity well-logging tools consisting of multiple tilted-coil antennas in cylindrically-layered Earth formations which have anisotropic conductivities and where each layer may be eccentric to the others (multieccentric formations). The cylindrically-layered, anisotropic, and multieccentric scenarios considered here are often encountered in deviated/horizontal drilling for hydrocarbon exploration, where the logging tool may be eccentric to the borehole due to mechanical vibrations and/or gravitational pull, and where eccentric invaded zones (of mud filtrate into the formation) may also arise because of gravitational pull on the mud filtrate.
A Peptide Targeted Contrast Agent Specific to Fibrin-Fibronectin Complexes for Cancer Molecular Imaging with MRI

A peptide targeted contrast agent, CLT1-(Gd-DTPA), was synthesized for molecular imaging of fibronectin−fibrin complexes in tumor tissue with magnetic resonance imaging (MRI). The T1 and T2 relaxivities of CLT1-(Gd-DTPA) were 4.22 and 4.45 mM−1 s−1 at 3 T, respectively. The targeted contrast agent specifically bound to tumor tissue and resulted in significant tumor contrast enhancement at a dose of 0.1 mmol Gd/kg for at least 60 min in mice bearing HT-29 human colon carcinoma xenografts as shown in dynamic MR images. In contrast, a control nontargeted contrast agent, Gd(DTPA-BMA), was cleared rapidly with little tumor enhancement 60 min postinjection. Tumor enhancement with CLT1-(Gd-DTPA) was significantly reduced after coinjection with a 3-fold excess of free CLT1 peptide. The preliminary study has shown that CLT1-(Gd-DTPA) can specifically bind to the fibrin−fibronectin complexes in tumor tissues, resulting in significant tumor enhancement. The targeted contrast agent has a potential for cancer molecular imaging with MRI.
Decreased expression of CD44, alpha-catenin, and deleted colon carcinoma and altered expression of beta-catenin in ulcerative colitis-associated dysplasia and carcinoma, as compared with sporadic colon neoplasms.

BACKGROUND To clarify the cell adhesion status in ulcerative colitis (UC)-associated colon neoplasm, expression of cell adhesion molecules were investigated and compared with that of sporadic colon neoplasm. METHODS A total of 14 low grade dysplasias, 16 high grade dysplasias, and 8 adenocarcinomas associated with UC and 17 sporadic adenomas with mild to moderate dysplasia, 22 adenomas with severe dysplasia, and 15 invasive adenocarcinomas were immunohistochemically examined using monoclonal antibodies against CD44, E-cadherin, alpha- and beta-catenin, and deleted colon carcinoma (DCC). RESULTS CD44, especially its standard form, and DCC expression was stronger in the sporadic colon neoplasms than in the UC-associated lesions. Although E-cadherin did not show significant differences between the two cases, alpha-catenin was more expressed in sporadic colon adenomas with severe dysplasia and carcinomas than in their UC-associated counterparts. Membranous beta-catenin staining was stronger in UC-associated neoplasms, whereas sporadic lesions had greater cytoplasmic and nuclear expression. CONCLUSIONS The differences in cell adhesion molecule expression suggests that UC-associated and sporadic colon neoplasms arise from different pathways of tumorigenesis.
[Pterygium excision using bulbar conjunctival autograft with intraoperative mitomycin C for primary pterygium: a retrospective assessment of 1832 eyes].

PURPOSE To retrospectively assess the efficacy of pterygium excision using bulbar conjunctival autograft with intraoperative mitomycin C (MMC) for primary pterygium. METHODS Primary pterygium eyes of 1482 patients (1832 eyes) which had undergone excision surgery using bulbar conjunctival autograft with intraoperative MMC in Miyata Eye Hospital were studied. The patients' background and position and the size of the pterygium were reviewed. For 1188 eyes that were followed up 1 year or longer, the recurrence rate and periods were assessed. Factors such as age, occupation, sex, the size of pterygium and the skill of the surgeon were examined as risk factors for recurrence. RESULTS Mean age was 65.0 +/- 10.0 years. The pterygium was in the nasal side in 99.0% of eyes, and the size in 55.4% of eyes was equal to the distance between one and two thirds of the radius of the cornea. The recurrence rate was 3.96% and was noted 9 months after the surgery. Significant risk factors were age of patient (p = 0.028) and the skill of the surgeon (p = 0.022). CONCLUSION Pterygium excision using bulbar conjunctival autograft with intraoperative mitomycin C was effective in primary pterygium.
Wave regime of electronics metal enclosure shielding in microwave region of electromagnetic impact

In this paper the wave regime of shielding the electronics metal enclosure in microwave region is under consideration. Physical interpretation of the formation of the resonance processes in wave regime is described. The potential levels of electromagnetic field penetration through the shielding shells that can include apertures are shown based on the analysis of the variety of experimental data. Summarized classification of the shielding frequency ranges taking into account the resonance of the electronics enclosure is given in conclusion.
Electron Microscopic Findings in Presbycusic Degeneration of the Basal Turn of the Human Cochlea

Three human temporal bones with presbycusis affecting the basal turn of the cochlea were studied by light and electron microscopy. Conditions in two ears examined by light microscopy were typical of primary neural degeneration, with a descending audiometric pattern, loss of cochlear neurons in the basal turn, and preservation of the organ of Corti. Ultrastructural analysis revealed normal hair cells and marked degenerative changes of the remaining neural fibers, especially in the basal turn. These changes included a decrease in the number of synapses at the base of hair cells, accumulation of cellular debris in the spiral bundles, abnormalities of the dendritic fibers and their sheaths in the osseous spiral lamina, and degenerative changes in the spiral ganglion cells and axons. These changes were interpreted as an intermediate stage of degeneration prior to total loss of nerve fibers and ganglion cells as visualized by light microscopy. In the third ear the changes observed were typical of primary degeneration of hair and supporting cells in the basal turn with secondary neural degeneration. Additional observations at an ultrastructural level included maintenance of the tight junctions of the scala media despite loss of both hair and supporting cells, suggesting a capacity for cellular “healing” in the inner ear. Degenerative changes were found in the remaining neural fibers in the osseous spiral lamina. In addition, there was marked thickening of the basilar membrane in the basal turn, which consisted of an increased number of fibrils and an accumulation of amorphous osmiophilic material in the basilar membrane. This finding supports the concept that mechanical alterations may occur in presbycusis of the basal turn.
Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission

Background Interventions to interrupt transmission of malaria from humans to mosquitoes represent an appealing approach to assist malaria elimination. A limitation has been the lack of systems to test the efficacy of such interventions before proceeding to efficacy trials in the field. We have previously demonstrated the feasibility of induced blood stage malaria (IBSM) infection with Plasmodium vivax. In this study, we report further validation of the IBSM model, and its evaluation for assessment of transmission of P. vivax to Anopheles stephensi mosquitoes. Methods Six healthy subjects (three cohorts, n = 2 per cohort) were infected with P. vivax by inoculation with parasitized erythrocytes. Parasite growth was monitored by quantitative PCR, and gametocytemia by quantitative reverse transcriptase PCR (qRT-PCR) for the mRNA pvs25. Parasite multiplication rate (PMR) and size of inoculum were calculated by linear regression. Mosquito transmission studies were undertaken by direct and membrane feeding assays over 3 days prior to commencement of antimalarial treatment, and midguts of blood fed mosquitoes dissected and checked for presence of oocysts after 7–9 days. Results The clinical course and parasitemia were consistent across cohorts, with all subjects developing mild to moderate symptoms of malaria. No serious adverse events were reported. Asymptomatic elevated liver function tests were detected in four of six subjects; these resolved without treatment. Direct feeding of mosquitoes was well tolerated. The estimated PMR was 9.9 fold per cycle. Low prevalence of mosquito infection was observed (1.8%; n = 32/1801) from both direct (4.5%; n = 20/411) and membrane (0.9%; n = 12/1360) feeds. Conclusion The P. vivax IBSM model proved safe and reliable. The clinical course and PMR were reproducible when compared with the previous study using this model. The IBSM model presented in this report shows promise as a system to test transmission-blocking interventions. Further work is required to validate transmission and increase its prevalence. Trial Registration Anzctr.org. au ACTRN12613001008718
24-Hour Changes in Circulating Prolactin, Follicle-Stimulating Hormone, Luteinizing Hormone, and Testosterone in Young Male Rats Subjected to Calorie Restriction

This work analyzes the effect of calorie restriction on the 24 h variation of pituitary-testicular function in young male Wistar rats by measuring the circulating levels of prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone. Control animals were provided an equilibrium calorie diet and the experimental animals a calorie-restriction diet equivalent to 66% of food restriction for four weeks starting on day 35 of life. Different groups of control and experimental rats were killed at 6 h intervals around the clock, beginning 1 h after light on (HALO). Compared to the control animals, the mean secretion of prolactin was augmented and that of LH and testosterone decreased in calorie-restricted rats, whereas FSH release remained unchanged. Significant changes in the 24 h secretory pattern of circulating prolactin, LH, and testosterone occurred in the calorie-restricted rats. These include the appearance of a second maximum of plasma prolactin at 21 HALO, blunting of the LH peak seen at 13 HALO, and phase-shift of the testosterone peak from 13 HALO in controls to 17 HALO in calorie-restricted rats. The significant positive correlation between individual LH and testosterone levels found in controls was no longer observed in calorie-restricted rats. Availability of nutrients presumably affects the mechanisms that modulate the circadian variation of the pituitary-gonadal axis in growing male rats.
Tissue Engineered Strategies for Skeletal Muscle Injury

Skeletal muscle injuries are common in athletes, occurring with direct and indirect mechanisms and marked residual effects, such as severe long-term pain and physical disability. Current therapy consists of conservative management including RICE protocol (rest, ice, compression and elevation), nonsteroidal anti-inflammatory drugs, and intramuscular corticosteroids. However, current management of muscle injuries often does not provide optimal restoration to preinjury status. New biological therapies, such as injection of platelet-rich plasma and stem-cell-based therapy, are appealing. Although some studies support PRP application in muscle-injury management, reasons for concern persist, and further research is required for a standardized and safe use of PRP in clinical practice. The role of stem cells needs to be confirmed, as studies are still limited and inconsistent. Further research is needed to identify mechanisms involved in muscle regeneration and in survival, proliferation, and differentiation of stem cells.
Mechanical factors favoring release from fouling release coatings

For some twenty years the marine coatings industry has been intrigued by polymer surfaces with low adhesion to other materials, especially to the biological glues used by marine organisms. Polymers with fouling release surfaces have been made from sundry materials, and their resistance to marine fouling in both static and dynamic tests has been evaluated in the world's oceans. Although the polymer surface property most frequently correlated with bioadhesion is its critical surface tension (γ? ), resistance to fouling is also influenced by other bulk and surface properties of the polymer. This paper reviews the types of bonding associated with polymeric materials used in fouling resistant coatings, describes the removal process in terms of fracture mechanics, and discusses the importance of surface energy, elastic modulus and coating thickness in the release of biofoulants.
Microevolution of Group A Streptococci In Vivo: Capturing Regulatory Networks Engaged in Sociomicrobiology, Niche Adaptation, and Hypervirulence

The onset of infection and the switch from primary to secondary niches are dramatic environmental changes that not only alter bacterial transcriptional programs, but also perturb their sociomicrobiology, often driving minor subpopulations with mutant phenotypes to prevail in specific niches. Having previously reported that M1T1 Streptococcus pyogenes become hypervirulent in mice due to selection of mutants in the covRS regulatory genes, we set out to dissect the impact of these mutations in vitro and in vivo from the impact of other adaptive events. Using a murine subcutaneous chamber model to sample the bacteria prior to selection or expansion of mutants, we compared gene expression dynamics of wild type (WT) and previously isolated animal-passaged (AP) covS mutant bacteria both in vitro and in vivo, and we found extensive transcriptional alterations of pathoadaptive and metabolic gene sets associated with invasion, immune evasion, tissue-dissemination, and metabolic reprogramming. In contrast to the virulence-associated differences between WT and AP bacteria, Phenotype Microarray analysis showed minor in vitro phenotypic differences between the two isogenic variants. Additionally, our results reflect that WT bacteria's rapid host-adaptive transcriptional reprogramming was not sufficient for their survival, and they were outnumbered by hypervirulent covS mutants with SpeB−/Sdahigh phenotype, which survived up to 14 days in mice chambers. Our findings demonstrate the engagement of unique regulatory modules in niche adaptation, implicate a critical role for bacterial genetic heterogeneity that surpasses transcriptional in vivo adaptation, and portray the dynamics underlying the selection of hypervirulent covS mutants over their parental WT cells.
Simultaneous Physiological Motion Cancellation and Depth Adaptation in Flexible Endoscopy

Flexible endoscopes are used in many diagnostic exams and surgical procedures in gastroenterology as well as in natural orifice transluminal endoscopic surgery. In order to assist the surgeon during these difficult procedures, physiological motion cancellation has been successfully applied on a robotized endoscope. However, the stability and performance of the classical controllers were ensured only on a small working area, thus preventing the surgeon to manually move the endoscope during motion rejection. In this paper, we propose original methods to improve the physiological motion rejection while taking into account manual depth changes performed by the surgeon. For this purpose, an adaptive repetitive controller based on depth estimation is proposed. The validity of the approach is demonstrated in in vitro experiments.
Accuracy of Stereolithography Parts: Mechanism and Modes of Distortion for a "Letter-H" Diagnostic Part

Rapid Prototyping and Manufacturing (RP&M) users need to compare the accuracy of various commercially available RP&M materials and processes. A good diagnostic test for both material and the fabrication process involves a 4-inch long "letter-H" diagnostic part. This diagnostic part, known as "H-4", was developed to measure the inherent dimensional characteristics ofvarious RP&M build materials. It is also less dependent on the calibration status of particular RP&M machines, and is excellent for the purpose of generating simple but meaningful accuracy information, which can be used to further understand the mechanism and the modes of distortion in RP&M materials. H-4 parts were prepared and built in Stereolithography Apparatus (SLA) using Ciba-Geigy epoxy based resins SL 5170 and SL 5180, and results were compared to acrylate based SL 5149. Experimental data involving the magnitude, mechanism, and the modes of distortion for these three resins are analyzed in this paper.
Tissue-specific patterns of allelically-skewed DNA methylation

ABSTRACT While DNA methylation is usually thought to be symmetrical across both alleles, there are some notable exceptions. Genomic imprinting and X chromosome inactivation are two well-studied sources of allele-specific methylation (ASM), but recent research has indicated a more complex pattern in which genotypic variation can be associated with allelically-skewed DNA methylation in cis. Given the known heterogeneity of DNA methylation across tissues and cell types we explored inter- and intra-individual variation in ASM across several regions of the human brain and whole blood from multiple individuals. Consistent with previous studies, we find widespread ASM with > 4% of the ∼220,000 loci interrogated showing evidence of allelically-skewed DNA methylation. We identify ASM flanking known imprinted regions, and show that ASM sites are enriched in DNase I hypersensitivity sites and often located in an extended genomic context of intermediate DNA methylation. We also detect examples of genotype-driven ASM, some of which are tissue-specific. These findings contribute to our understanding of the nature of differential DNA methylation across tissues and have important implications for genetic studies of complex disease. As a resource to the community, ASM patterns across each of the tissues studied are available in a searchable online database: http://epigenetics.essex. ac.uk/ASMBrainBlood.
Stabhyli: a tool for automatic stability verification of non-linear hybrid systems

We present Stabhyli, a tool that automatically proves stability of non-linear hybrid systems. Hybrid systems are systems that exhibit discrete as well as continuous behavior. The stability property basically ensures that a system exposed to a faulty environment (e.g. suffering from disturbances) will be able to regain a "good" operation mode as long as errors occur not too frequently. Stabilizing Hybrid systems are omnipresent, for instance in control applications where a discrete controller is controlling a time-continuous process such as a car's movement or a particular chemical reaction. We have implemented a tool to automatically derive a certificate of stability for non-linear hybrid systems. Certificates are obtained by Lyapunov theory combined with decomposition and composition techniques.