Miracle-dz/UniFAR-FTUs huggingface dataset:
Catching up with Jesse Jackson: Being oppressed and being somebody

Abstract Current anti‐racist thinking is unable to explain events such as the Rushdie affair for it rests on a sociology which makes it difficult or impossible to connect theoretically issues of race with ethnicity. Racial minority groups thus become shadows who make no contribution to outcomes. This not only leads to inadequate explanations but works to undermine group pride, a vital motor of racial equality. The law on racial discrimination is evidence of the dialectical relationship between race and ethnicity, for the concept of indirect racial discrimination is concrete proof that culture is no less than class is a distinct dimension of race and racial discrimination, and points the way to a policy of equality through pluralism.
PARALLEL PROCESSING OF DISTRIBUTED TREES : A PATTERN LANGUAGE AND APPLICATIONS

Parallelism could be used to provide better performance to heavy applications, while design patterns could be used to facilitate their design. There is a wide range of applications that rely on large hierarchical structures, like trees. A set of design patterns are presented that could be used to model such applications in a parallel and distributed way. This paper also presents the modeling of several parallel and distributed applications to which the presented set of design patterns are applied.
Relations of Inflammatory Biomarkers and Common Genetic Variants With Arterial Stiffness and Wave Reflection

Inflammation causes vascular dysfunction and perpetuates proatherosclerotic processes. We hypothesized that a broad panel of inflammatory biomarkers and single nucleotide polymorphisms in inflammatory genes is associated with vascular stiffness. We assessed 12 circulating inflammatory biomarkers (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase-A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, osteoprotegerin, P-selectin, and tumor necrosis factor receptor-II) in relation to tonometry variables (central pulse pressure, mean arterial pressure, forward pressure wave, reflected pressure wave, carotid-femoral pulse wave velocity, and augmentation index) measured in 2409 Framingham Heart Study participants (mean age: 60 years; 55% women; 13% ethnic/racial minorities). Single nucleotide polymorphisms (n=2195) in 240 inflammatory candidate genes were related to tonometry measures in 1036 white individuals. In multivariable analyses, biomarkers explained <1% of any tonometry measure variance. Applying backward elimination, markers related to tonometry (P<0.01) were as follows: tumor necrosis factor receptor-II (inversely) with mean arterial pressure; C-reactive protein (positively) and lipoprotein-associated phospholipase-A2 (inversely) with reflected pressure wave; and interleukin-6 and osteoprotegerin (positively) with carotid-femoral pulse wave velocity. In genetic association analyses, lowest P values (false discovery rate <0.50) were observed for rs10509561 (FAS), P=6.6×10−5 for central pulse pressure and rs11559271 (ITGB2), P=1.1×10−4 for mean arterial pressure. These data demonstrate that, in a community-based sample, circulating inflammatory markers tumor necrosis factor receptor-II (mean arterial pressure), C-reactive protein, lipoprotein-associated phospholipase-A2 activity (reflected pressure wave), interleukin-6, and osteoprotegerin (carotid-femoral pulse wave velocity) were significantly but modestly associated with measures of arterial stiffness and wave reflection. Additional studies are needed to determine whether variation in inflammatory marker genes is associated with tonometry measures.
The V Antigen of Yersinia pestisRegulates Yop Vectorial Targeting as Well as Yop Secretion through Effects on YopB and LcrG

ABSTRACT Yersinia pestis expresses a set of secreted proteins called Yops and the bifunctional LcrV, which has both regulatory and antihost functions. Yops and LcrV expression and the activity of the type III mechanism for their secretion are coordinately regulated by environmental signals such as Ca2+ concentration and eukaryotic cell contact. In vitro, Yops and LcrV are secreted into the culture medium in the absence of Ca2+ as part of the low-Ca2+ response (LCR). The LCR is induced in a tissue culture model by contact with eukaryotic cells that results in Yop translocation into cells and subsequent cytotoxicity. The secretion mechanism is believed to indirectly regulate expression oflcrV and yop operons by controlling the intracellular concentration of a secreted negative regulator. LcrG, a secretion-regulatory protein, is thought to block secretion of Yops and LcrV, possibly at the inner face of the inner membrane. A recent model proposes that when the LCR is induced, the increased expression of LcrV yields an excess of LcrV relative to LcrG, and this is sufficient for LcrV to bind LcrG and unblock secretion. To test this LcrG titration model, LcrG and LcrV were expressed alone or together in a newly constructed lcrG deletion strain, a ΔlcrG2mutant, of Y. pestis that produces low levels of LcrV and constitutively expresses and secretes Yops. Overexpression of LcrG in this mutant background was able to block secretion and depress expression of Yops in the presence of Ca2+ and to dramatically decrease Yop expression and secretion in growth medium lacking Ca2+. Overexpression of both LcrG and LcrV in the ΔlcrG2 strain restored wild-type levels of Yop expression and Ca2+ control of Yop secretion. Surprisingly, when HeLa cells were infected with the ΔlcrG2 strain, no cytotoxicity was apparent and translocation of Yops was abolished. This correlated with an altered distribution of YopB as measured by accessibility to trypsin. These effects were not due to the absence of LcrG, because they were alleviated by restoration of LcrV expression and secretion alone. LcrV itself was found to enter HeLa cells in a nonpolarized manner. These studies supported the LcrG titration model of LcrV’s regulatory effect at the level of Yop secretion and revealed a further role of LcrV in the deployment of YopB, which in turn is essential for the vectorial translocation of Yops into eukaryotic cells.
Unbiasing Truncated Backpropagation Through Time

\emph{Truncated Backpropagation Through Time} (truncated BPTT, \cite{jaeger2002tutorial}) is a widespread method for learning recurrent computational graphs. Truncated BPTT keeps the computational benefits of \emph{Backpropagation Through Time} (BPTT \cite{werbos:bptt}) while relieving the need for a complete backtrack through the whole data sequence at every step. However, truncation favors short-term dependencies: the gradient estimate of truncated BPTT is biased, so that it does not benefit from the convergence guarantees from stochastic gradient theory. We introduce \emph{Anticipated Reweighted Truncated Backpropagation} (ARTBP), an algorithm that keeps the computational benefits of truncated BPTT, while providing unbiasedness. ARTBP works by using variable truncation lengths together with carefully chosen compensation factors in the backpropagation equation. We check the viability of ARTBP on two tasks. First, a simple synthetic task where careful balancing of temporal dependencies at different scales is needed: truncated BPTT displays unreliable performance, and in worst case scenarios, divergence, while ARTBP converges reliably. Second, on Penn Treebank character-level language modelling \cite{ptb_proc}, ARTBP slightly outperforms truncated BPTT.
Outcome-specific Charlson Comorbidity Indices for Predicting Poor Inpatient Outcomes Following Noncardiac Surgery Using Hospital Administrative Data

Background:A need exists for adapting existing perioperative risk stratification methods such as the Charlson Comorbidity Index (CCI) for application with hospital administrative data in noncardiac surgery populations. Objective:Develop and validate outcome-specific CCIs for predicting inpatient mortality, and cardiac and renal morbidity in noncardiac surgery patients using hospital administrative data. Methods:We used hospital administrative data from the 2010 and 2011 California State Inpatient Database (SID) to develop (derivation cohort: 2010 SID, n=177,280) and validate (validation cohort: 2011 SID, n=179,145) 3 outcome-specific CCIs. Along with the 17 CCI comorbidities, the clinical importance and weighted point scores for age, male sex, race, emergent admission, and high-risk surgery were also determined from the coefficients of a logistic regression model. Cumulative outcome-specific CCI, CCI, and age-adjusted CCI (AACCI) scores were calculated for each patient. Receiver-operator characteristic curve analyses were used to determine the prognostic accuracy (area under the curve) of each outcome-specific CCIs, the CCI, and the AACCI. Risk was stratified according to cumulative point scores for each outcome-specific CCI, and posttest probabilities for each risk category were calculated. Results:All outcome-specific CCIs showed good performance as a prognostic tools (area under the curve>0.800 for all) and performed better than the CCI and AACCI. We attached clinical relevance to a given cumulative point score by determining posttest probabilities for each outcome-specific index. Conclusions:We successfully adapted and validated 3 outcome-specific CCIs for use in noncardiac surgery patients based on ICD-9 and hospital admission data. Further validation of these outcome-specific CCIs is warranted.
Comparison of MRI and Wrist Arthroscopy for Assessment of Wrist Cartilage

In order to perform motion-preserving procedures for wrist arthritis rather than total joint fusion, it is important to determine the integrity of specific areas of wrist cartilage. This is generally performed using a wrist arthroscope and by directly visualising the cartilage. Twenty patients with wrist pain were investigated over a 1-year period with both MRI and wrist arthroscopy. Kappa analysis was used to compare the two methods of cartilage assessment. There is only a fair correlation (K = 0.38) between the two methods. With only a fair correlation between arthroscopy and MRI, it cannot be concluded that the two methods are equivalent for assessing wrist cartilage and, as such, wrist arthroscopy still has an important role to play in the assessment of a painful degenerative wrist.
Automatic Programming for Streams

Most automatic programming research has focused on programs which terminate and which produce output values upon termination. By contrast, programs which operate on streams of data usually do not terminate and usually produce streams of output data during execution. Such stream programs may be specified with a technique which is a generalization of specification techniques for conventional programs The use of transformations also seems to be an appropriate technique for automatically synthesizing stream programs.
Stability analysis for a hexapod robot walking on slopes

This paper describes a hexapod robot which uses CPG method to generate different gaits. Simulation results demonstrate the stability of the CPG model. In order to inspect the gradeability of the robot when climbing in uneven slopes, a criterion called force-angle stability is used to measure the performance of the robot which runs in complex environment with different gaits. And experiment shows the difference of various gaits. Thus a proper gait can be summarized and applied to complex environment or uneven slopes.
Mapping ecology of literacies in educational setting: the case of local mother tongues vis-à-vis Urdu and English languages in Pakistan

This study critically examines the literacy levels of undergraduate students in Pakistan to compare and contrast the proficiency levels, particularly reading and writing of their mother tongues versus Urdu and English, and to study real and perceived vitality of local/regional mother tongues vis-à-vis Urdu and English. The research investigated 162 undergraduate students using questionnaires, semi-structured interviews and participant observation. Drawing principally on Continua of Biliteracy, an ecological framework (“Revisiting the Continua of Biliteracy: International and Critical Perspectives.” Language and Education: An International Journal 14 (2): 96–122; Continua of Biliteracy: An Ecological Framework for Educational Policy, Research, and Practice in Multilingual Settings. Clevedon: Multilingual Matters), the data suggest that the respondents’ proficiency levels in academia-oriented skills like reading and writing are considerably lower in mother tongues than in Urdu and English languages. The respondents tend to attach greater value to academic literacy in Urdu and English over their mother tongues for they believe Urdu and English hold significant pragmatic and economistic value as languages of power and wealth. Local mother tongues are perceived to be good as identity carriers in a multilingual and multiethnic country, and their use could best be made in intra-ethnic interaction and family chitchat. As per Continua model, literacy situations across contexts, development and content indicate an explicit privileging of Urdu and English (traditionally more powerful end) of continuum over local mother tongues (traditionally less powerful end).
Essential role of endocytosis for interleukin-4-receptor-mediated JAK/STAT signalling

ABSTRACT Many important signalling cascades operate through specialized signalling endosomes, but a corresponding mechanism has as yet not been described for hematopoietic cytokine receptors. Based on live-cell affinity measurements, we recently proposed that ligand-induced interleukin-4 receptor (IL-4R) complex formation and thus JAK/STAT pathway activation requires a local subcellular increase in receptor density. Here, we show that this concentration step is provided by the internalization of IL-4R subunits through a constitutive, Rac1-, Pak- and actin-mediated endocytosis route that causes IL-4R subunits to become enriched by about two orders of magnitude within a population of cortical endosomes. Consistently, ligand-induced receptor dimers are preferentially detected within these endosomes. IL-4 signalling can be blocked by pharmacological inhibitors targeting the actin polymerization machinery driving receptor internalization, placing endocytosis unambigously upstream of receptor activation. Taken together, these observations demonstrate a role for endocytosis that is mechanistically distinct from the scaffolding function of signalling endosomes in other pathways. Summary: Constitutive receptor internalization is required for IL-4R signalling. Increased endosomal concentrations allow receptor dimerization that is disfavoured at endogenous plasma membrane densities.
Fibroblast Growth Factor Signaling and Basement Membrane Assembly Are Connected during Epithelial Morphogenesis of the Embryoid Body

Fibroblast growth factors and receptors are intimately connected to the extracellular matrix by their affinity to heparan sulfate proteoglycans. They mediate multiple processes during embryonic development and adult life. In this study, embryonic stem cell–derived embryoid bodies were used to model fibroblast growth factor signaling during early epithelial morphogenesis. To avoid redundancy caused by multiple receptors, we employed a dominant negative mutation of Fgfr2. Mutant-derived embryoid bodies failed to form endoderm, ectoderm, and basement membrane and did not cavitate. However, in mixed cultures they displayed complete differentiation induced by extracellular products of the normal cell. Evidence will be presented here that at least one of these products is the basement membrane or factors connected to it. It will be shown that in the mutant, collagen IV and laminin-1 synthesis is coordinately suppressed. We will demonstrate that the basement membrane is required for embryoid body differentiation by rescuing columnar ectoderm differentiation and cavitation in the mutant by externally added basement membrane proteins. This treatment induced transcription of Eomesodermin, an early developmental gene, suggesting that purified basement membrane proteins can activate inherent developmental programs. Our results provide a new paradigm for the role of fibroblast growth factor signaling in basement membrane formation and epithelial differentiation.
“Dye in the Water”

Many beaches are characterized by rip currents—strong, narrow flows that can quickly carry bathers offshore, often against their will. However, despite long-standing efforts at community education and awareness strategies, people continue to drown in rip currents at high rates. Here we describe a simple, but powerful visual-based risk communication approach involving imagery associated with releases of colored dye into rip currents that has been used as an outreach tool with success in Australia. This approach has the potential to transcend limitations of traditional education approaches and bring the rip current hazard to life for a largely unaware public.
Loading and Power Control for a High-Efficiency Class E PA-Driven Megahertz WPT System

In this paper, the loading effect of a Class E power amplifier (PA) driven 6.78 megahertz (MHz) wireless power transfer (WPT) system is analyzed at both circuit and system levels. A buck converter is introduced and controlled to track an optimal equivalent load that maximizes the system efficiency under uncertainties in the relative position of coils and the final load. For power control, an additional degree of freedom is provided by adding an ultracapacitor bank. A control strategy is proposed to track the maximum efficiency and charge/discharge the ultracapacitor bank through the on/off control of the Class E PA. Thus, high system efficiency can be maintained under various uncertainties and load power demands. Finally, the theoretical analysis and the control scheme are validated in experiments. The results show that the proposed Class E PA-driven MHz WPT system can stably achieve a high efficiency under different coil distances and various constant/pulsed power profiles. The measured highest system efficiency can reach 72.1% at a load power level of 10 W.
Alternative Professional Roles in Health Care Delivery: Leadership Patterns in Self-Help Groups

The increasing professionalization of health care delivery systems, improved client awareness, funding cutbacks, and an emphasis on voluntarism have led recipients of health services to turn increasingly to self-help groups. This article examines the leadership and organizational pattern of such groups, using a study of 43 self-help groups from around the U.S. whose members are parents of children with cancer. Three leadership patterns emerged: groups were independent and parent-led, were led by professionals, or had a shared leadership of parents and professionals. Data indicate that the professionally led groups were the smallest, leastformal, and had the narrowest range of activities. The groups with shared leadership had the greatest longevity, tended most often to retain as members parents of deceased children. The authors conclude that such coalitions of clients and professionals are vital for ensuring proper service delivery at a time when health care systems will likely remain bureaucratic and public resources for professional care are being reduced.
Characterization of a Clp Protease Gene Regulator and the Reaeration Response in Mycobacterium tuberculosis

Mycobacterium tuberculosis (MTB) enters a non-replicating state when exposed to low oxygen tension, a condition the bacillus encounters in granulomas during infection. Determining how mycobacteria enter and maintain this state is a major focus of research. However, from a public health standpoint the importance of latent TB is its ability to reactivate. The mechanism by which mycobacteria return to a replicating state upon re-exposure to favorable conditions is not understood. In this study, we utilized reaeration from a defined hypoxia model to characterize the adaptive response of MTB following a return to favorable growth conditions. Global transcriptional analysis identified the ∼100 gene Reaeration Response, induced relative to both log-phase and hypoxic MTB. This response includes chaperones and proteases, as well as the transcription factor Rv2745c, which we characterize as a Clp protease gene regulator (ClgR) orthologue. During reaeration, genes repressed during hypoxia are also upregulated in a wave of transcription that includes genes crucial to transcription, translation and oxidative phosphorylation and culminates in bacterial replication. In sum, this study defines a new transcriptional response of MTB with potential relevance to disease, and implicates ClgR as a regulator involved in resumption of replication following hypoxia.
Measures of endothelial dysfunction predict response to cardiac resynchronisation therapy

Objectives Cardiac resynchronisation therapy (CRT) improves morbidity and mortality in heart failure (HF). Impaired endothelial function, as measured by flow-mediated dilation (FMD) is associated with increased morbidity and mortality in HF and may help to differentiate responders from non-responders. Methods 19 patients were recruited, comprising 94% men, mean age 69±8 years, New York Heart Association functional classes II–IV, QRSd 161±21 ms and mean left ventricular ejection fraction 26±8%. Markers of response and FMD were measured at baseline, 6 and 12 months following CRT. Results 14 patients were responders to CRT. Responders had significant improvements in VO2 (12.6±1.7 to 14.7±1.5 mL/kg/min, p<0.05), quality of life score (44.4±22.9–24.1±21.3, p<0.01), left ventricular end diastolic volume (201.5±72.5 mL–121.3±72.0 mL, p<0.01) and 6-min walk distance (374.0±112.8 m at baseline to 418.1±105.3 m, p<0.05). Baseline FMD in responders was 2.9±1.9% and 7.4±3.73% in non-responders (p<0.05). Conclusions Response to CRT at 6 and 12 months is predicted by baseline FMD. This study confirms that FMD identifies responders to CRT, due to endothelium-dependent mechanisms alone.
Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography: Theory, Procedure, and Normal Values

A method is described for quantifying regional cerebral blood flow (rCBF), oxygen extraction (rOER), and oxygen utilization (rCMRO2) in man noninvasivey, using inhaled 15O-labeled CO2 and O2 and positron emission tomography. The theoretical considerations and practical aspects are described. The results of rCBF, rCMRO2, and rOER for gray and white matter in normal volunteers are presented. The significance and limitations of the results are discussed. The method appears suitable for the study of human cerebral aerobic metabolism and blood flow under differing physiological conditions and in a wide variety of neurological disorders.
Multi-Oriented English Text Line Extraction Using Background and Foreground Information

In graphical documents (map, engineering drawing), artistic documents etc. there exist many printed materials where text lines are not parallel to each other and they are multi-oriented and curve in nature. For the OCR of such documents we need to extract individual text lines from the documents. Extraction of individual text lines from multi-oriented and/or curved text document is a difficult problem. In this paper, we propose a novel method to extract individual text lines from such document pages and the method is based on the foreground and background information of the characters of the text. To take care of background information, water reservoir concept is used here. In the proposed scheme at first, individual components are detected and grouped into 3-character clusters using their inter-component distance, size and positional information. Applying concept of graph, initial 3-character clusters are merged to have larger cluster group. Using inter-character background information, orientations of the extreme characters of a larger cluster are decided and based on these orientation, two candidate regions are formed from the cluster. Finally, with the help of these candidate regions, individual lines are extracted. From the experiment, we obtained encouraging result.