Miracle-dz/UniFAR-FTUs huggingface dataset:
SNOMED clinical terms: overview of the development process and project status

Two large health care reference terminologies, SNOMED RT and Clinical Terms Version 3 , are in the process of being merged to form a comprehensive new work referred to as SNOMED Clinical Terms. The College of American Pathologists and the United Kingdom s National Health Service have entered into a collaborative agreement to develop this new work. Both organizations have extensive terminology development and maintenance experience. This paper discusses the process and status of SNOMED CT development and how the resources and expertise of both organizations are being used to develop this new terminological resource. The preliminary results of the merger process, including mapping, the merger of upper levels of each hierarchy, and attribute harmonization are also discussed.
Additive manufactured W-band waveguide components

This paper presents several W-band (75–110 GHz) WR-10 waveguide components fabricated using both direct metal laser sintering (DMLS) and stereolithography (SLA), in aluminum, nickel and copper alloys and metal-coated plastic (MCP). The RF performance and surface roughness are measured, and the loss due to surface roughness quantified. The measured loss at 95 GHz ranges from 0.055 dB/cm for the copper-plated plastic waveguides to 0.37 dB/cm for the nickel alloy. From a loss budget study, it is found that standard models do not accurately predict loss due to surface roughness for very rough surfaces. This paper presents the current state-of-the-art in available additive manufactured (AM) waveguide components at W-band.
Prognostic implication of relative regional strain ratio in cardiac amyloidosis

Objective Cardiac amyloidosis (CA) is a rapidly progressive disease that portends poor prognosis. Our objective was to evaluate the prognostic impact of relative regional strain ratio (RRSR, a measure of the relative apical sparing of longitudinal strain (LS)) in CA. Methods This is a retrospective study evaluating 97 patients with CA from 2004 to 2013. Patients were included if they met criteria for CA based on endomyocardial biopsy or advanced imaging criteria coupled with either extracardiac biopsy or genetic analysis. Baseline clinical and imaging data were collected and compared between light-chain amyloidosis (AL) (n=59) and transthyretin amyloidosis (ATTR) (n=38) subtypes. RRSR was defined as the average apical LS divided by the sum of the average mid and basal LS values. A Cox proportional hazards model was used to assess the effects of clinical and echocardiographic characteristics, including RRSR, on the outcome of time to death or heart transplantation. Results Despite younger age, the AL subtype had a statistically significant association with the composite outcome as compared with ATTR (p=0.022). Log-transformed RRSR was independently associated with the composite outcome at 5 years (HR 2.45 (1.36 to 4.40), p=0.003). Patients with low ejection fraction and high RRSR had the worst prognosis. In multivariable analysis, RRSR remained predictive of the primary outcome (p=0.018). Addition of covariates related to systolic function (global LS and ejection fraction) to the model attenuated this effect. Conclusions High RRSR is adversely prognostic in patients with cardiac amyloid. This novel tool is both diagnostic and prognostic and may have implications in management and suitability for treatment.
Nitric oxide: Orchestrator of endothelium-dependent responses

Abstract The present review first summarizes the complex chain of events, in endothelial and vascular smooth muscle cells, that leads to endothelium-dependent relaxations (vasodilatations) due to the generation of nitric oxide (NO) by endothelial nitric oxide synthase (eNOS) and how therapeutic interventions may improve the bioavailability of NO and thus prevent/cure endothelial dysfunction. Then, the role of other endothelium-derived mediators (endothelium-derived hyperpolarizing (EDHF) and contracting (EDCF) factors, endothelin-1) and signals (myoendothelial coupling) is summarized also, with special emphasis on their interaction(s) with the NO pathway, which make the latter not only a major mediator but also a key regulator of endothelium-dependent responses.
MLPA vs multiprobe FISH: comparison of two methods for the screening of subtelomeric rearrangements in 50 patients with idiopathic mental retardation

Subtelomeric rearrangements not visible by conventional cytogenetic analysis have been reported to occur in approximately 5% of patients with unexplained mental retardation (MR). As the prevalence of MR is high, many patients need to be screened for these chromosomal abnormalities routinely. Multiplex ligation‐dependent probe amplification (MLPA) is a new technique for measuring sequence dosage, allowing large number of samples to be processed simultaneously and thus significantly reducing laboratory work. We have assessed its performance for the detection of subtelomeric rearrangements by comparing the results with those of our previous multiprobe fluorescence in situ hybridization (FISH) assay. We have tested 50 patients with idiopathic MR, dysmorphic features, congenital malformations, and/or familial history of MR. Our results show a high degree of concordance between the two techniques for the 50 samples tested. On the basis of these results, we conclude that MLPA is a rapid, accurate, reliable, and cost‐effective alternative to FISH for the screening of subtelomeric rearrangements in patients with idiopathic MR.
Frequency of Proliferation, Apoptosis, and Their Ratio During Rat Colon Carcinogenesis and Their Characteristic Pattern in the Dimethylhydrazine-Induced Colon Adenoma and Carcinoma

The imbalance between the cell proliferation and cell loss plays a crucial role in the carcinogenesis and tumor progression. However, the direction of these changes is still the matter of discussion. Thus, the aim of this study was to evaluate the proliferative activity, apoptotic activity, and proliferation/apoptosis ratio (P/A) assessed every 6 weeks in the colonic epithelium during 21 weeks of dimethylhydrazine (DMH) treatment in male Wistar rats. Moreover, it is necessary to answer the question whether these analyzed parameters correlate with the grade of differentiation or dysplasia of the induced tumors. It was found that DMH administration enhanced the proliferation in week 12 and 18 when compared with week 6. The proliferation in the control group did not change during the study. Up to week 12 of the experiment, there were no statistically significant differences between proliferative activity in the control and DMH-treated groups. In week 18, the proliferation in DMH-treated group was higher than in the control group. At all time points of the study, the apoptotic activity in the DMH-treated groups was significantly higher than in controls and in both groups, they dropped during the study. In the control group, apoptotic activity decreased in week 18 and was lower in comparison to that in week 6 and 12. In the group treated with DMH, apoptosis dropped at week 12 and was lower than in week 6. The P/A ratio did not change during the study in the control group, but increased in the DMH-treated group. After 21 weeks of DMH administration, 28 cases of colon adenocarcinoma and nine cases of colon adenoma were obtained and classified according to the WHO classification (1989) for human colon tumors. The adenocarcinomas were divided into four groups: well, moderately, poorly differentiated, and signet-ring cell carcinoma. The colon adenomas were divided into three groups: adenoma with mild, moderate, and severe grade of dysplasia. The proliferative activity in signet-ring cell carcinoma was significantly smaller than in well, moderately, and poorly differentiated adenocarcinoma and apoptotic activity was smaller than in well-differentiated adenocarcinoma. A weak (statistically nonsignificant) negative correlation was also observed between the proliferative and apoptotic activity in adenocarcinoma or adenoma and their grade of dedifferentiation or dysplasia, respectively.
A critical comparison between two classical and a kit‐based method for mitochondria isolation

Numerous protocols for isolation of mitochondria are available. Here, three methods for the isolation of intact mitochondria from mouse liver tissues are compared with regard to yield, purity and activity. Mitochondria were isolated by sucrose density gradient ultracentrifugation, free‐flow electrophoresis or a commercially available kit‐based method. Our analyses show that the sophisticated (and most expensive) free‐flow electrophoresis method enables isolation of intact mitochondria with an enrichment of approximately 70%. Using the classical density centrifugation method is very laborious and time‐consuming, but delivers about 57% intact mitochondria. Using standard laboratory equipment in a quick and simple procedure, the kit provides approximately 50% intact mitochondria, suitable for most standard investigations.
Applying graph models and Neural Networks on reconfigurable antennas for cognitive radio applications

In this paper, graph models and Neural Networks (NNs) are applied to reconfigurable antennas and both techniques are analyzed to be used for cognitive radio applications. The use of NNs to synthesize different antenna configurations and the use of graph models to optimize the performance of such configurations are addressed and investigated. The application of both tools on reconfigurable antennas has proven to be beneficial in applications where software control and fast response are required. Thus the incorporation of such techniques on an FPGA (Field Programmable Gate Array) creates a self adjusting software defined antenna that can be applied to many wireless communication applications such as cognitive radio.
Testing the equality of two survival functions with right truncated data

To compare the survival functions based on right‐truncated data, Lagakos et al. proposed a weighted logrank test based on a reverse time scale. This is in contrast to Bilker and Wang, who suggested a semi‐parametric version of the Mann–Whitney test by assuming that the distribution of truncation times is known or can be estimated parametrically. The approach of Lagakos et al. is simple and elegant, but the weight function in their method depends on the underlying cumulative hazard functions even under proportional hazards models. On the other hand, a semi‐parametric test may have better efficiency, but it may be sensitive to misspecification of the distribution of truncation times. Therefore, this paper proposes a non‐parametric test statistic based on the integrated weighted difference between two estimated survival functions in forward time. The comparative results from a simulation study are presented and the implementation of these methods to a real data set is demonstrated. Copyright © 2006 John Wiley & Sons, Ltd.
Signal peptide amino acid sequences in Escherichia coli contain information related to final protein localization. A multivariate data analysis.

With few exceptions, the signal peptides from proteins inserted into, or translocated through, the membranes of gram‐negative bacteria or the endoplasmic reticulum of eukaryotes have no sequence homologies. Therefore these signal peptides have not been considered to contain information related to the different final localizations of the proteins. In this study, 43 signal peptide amino acid sequences from proteins with different final localizations in Escherichia coli have been subjected to a multivariate data analysis. Each amino acid residue was characterized by 20 physico‐chemical properties, yielding a multivariate property profile for each peptide. The similarities/dissimilarities in the property profiles for the signal peptides from different classes were compared with each other by generating few‐dimensional partial least squares (PLS) discriminant plots. With this approach, signal peptides from proteins localized to the periplasmic space (PS), the outer membrane (OM), and the extracellular surroundings (excreted proteins), were separated into distinct groups. Signal peptides from pili proteins were not separated from the OM signal peptides and only partly from the PS signal peptides, but were clearly different from the signal peptides of the excreted proteins. Signal peptides from inner membrane proteins were similar to those of the PS peptides. The size and the hydrophobicity of different peptide segments were responsible for the separation of the signal peptide classes. For example, the hydrophobicity of the N‐terminal segment of the signal peptides increased with an increased distance from the cytoplasm of the final localization for the corresponding proteins. Thus, many signal peptides from proteins with different final localizations in E. coli have different discernible physico‐chemical profiles.
Evidence for NQO1 and NQO2 catalyzed reduction of ortho- and para-quinone methides

Abstract NAD(P)H:quinone oxidoreductase (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) catalyze the two-electron reduction of quinones and thereby prevent generation of toxic radicals. Quinone methides (QMs) covalently react with cellular macromolecules to form DNA adducts and/or protein conjugates resulting in toxicity and carcinogenesis. Based on similar structural features of quinones and QMs, it is logical to assume that NQO1 and/or NQO2 could also catalyze the two-electron reduction of QMs. However, hitherto the reduction of QMs, as both endogenous and/or exogenous biological substrates, by either NQO1/NQO2 has never been demonstrated. Here we show for the first time that both NQO1 and NQO2 can catalyze the reduction of electrophilic ortho-/para-QMs. The involvement of the enzyme in the reduction of p-cresol quinone methide (PCQM) and o-cresol quinone methide (OCQM) was demonstrated by reappearance of NQO1/NQO2-FAD peak at 450 nm after addition of the QMs to the assay mixture. Further reduction of methides by NQO1/NQO2 was confirmed by analyzing the assay mixture by tandem mass spectrometry. Preliminary kinetic studies show that NQO2 is faster in reducing QMs than its homolog NQO1, and moreover, ortho-QMs are reduced faster than para-QMs. Enzyme-substrate docking studies showed results consistent with enzyme catalysis. Thus, NQO1/NQO2 can play a significant role in deactivation of QMs.
Maintaining Healthy Population Diversity Using Adaptive Crossover, Mutation, and Selection

This paper presents ACROMUSE, a novel genetic algorithm (GA) which adapts crossover, mutation, and selection parameters. ACROMUSEs objective is to create and maintain a diverse population of highly-fit (healthy) individuals, capable of adapting quickly to fitness landscape change and well-suited to the efficient optimization of multimodal fitness landscapes. A new methodology is introduced for determining standard population diversity (SPD) and an original measure of healthy population diversity (HPD) is proposed. The SPD measure is employed to adapt crossover and mutation, while selection pressure is controlled by adapting tournament size according to HPD. In addition to selection pressure control, ACROMUSE tournament selection selects individuals according to healthy diversity contribution rather than fitness. This proposed selection mechanism simultaneously promotes diversity and fitness within the population. The performance of ACROMUSE is evaluated using various multimodal benchmark functions. Statistically significant results are presented comparing ACROMUSEs fitness and diversity performance to that of several other GAs. By maintaining a diverse population of healthy individuals, ACROMUSE responds to fitness landscape change by restoring better fitness scores faster than other GAs. Analysis of the adaptive operators illustrates that the key benefit of ACROMUSE is the synergy of the operators working together to achieve an effective balance between exploration and exploitation.
Effectiveness of Shockwave Treatment Combined With Eccentric Training for Patellar Tendinopathy: A Double-Blinded Randomized Study

Objective: To evaluate the effectiveness of a combined treatment of focused shockwave therapy (ESWT) and eccentric training compared with sham-shockwave therapy (placebo) and eccentric training in participants with patellar tendinopathy (PT) after 24 weeks. Design: Randomized controlled trial. Setting: Sports medicine departments of a university hospital and a general hospital in the Netherlands. Participants: Fifty-two physically active male and female participants with a clinical diagnosis of PT (mean age: 28.6 years; range, 18-45) were randomly allocated to the ESWT (n = 22) or sham shockwave (n = 30). Interventions: Extracorporeal shockwave therapy and sham shockwave were applied in 3 sessions at 1-week intervals with a piezoelectric device. All participants were instructed to perform eccentric exercises (3 sets of 15 repetitions twice a day) for 3 months on a decline board at home. Main Outcome Measures: The Victorian Institute of Sport Assessment-Patella (VISA-P) scores (primary), pain scores during functional knee loading tests, and Likert score (secondary) were registered at baseline and at 6, 12, and 24 weeks after the start with the ESWT or sham-shockwave treatment. Results: No significant differences for the primary and secondary outcome measures were found between the groups. In the ESWT/eccentric group, the VISA-P increased from 54.5 ± 15.4 to 70.9 ± 17.8, whereas the VISA-P in the sham-shockwave/eccentric group increased from 58.9 ± 14.6 to 78.2 ± 15.8 (between-group change in VISA-P at 24 weeks −4.8; 95% confidence interval, −12.7 to 3.0, P = 0.150). Conclusions: This study showed no additional effect of 3 sessions ESWT in participants with PT treated with eccentric exercises. The results should be interpreted with caution because of small sample size and considerable loss to follow-up, particularly in the ESWT group.
Endovascular management of fusiform aneurysm of anterior temporal artery: Technical report

Background: The treatment of a rare, nontraumatic, fusiform aneurysm of the anterior temporal artery (ATA) via endovascular techniques is presented, and procedural nuances are highlighted. Methods: We performed a retrospective chart review and collected demographic and clinical data on the patient presented here; procedural details were extracted from operative notes. Results: Following successful balloon test occlusion (BTO) of the ATA, complete coil embolization of the ATA, and its associated fusiform aneurysm was performed. Postprocedurally, the patient did not suffer any adverse neurological sequelae. Conclusion: Selective BTO of intracranial branch vessels is safe, technically feasible, and could serve as a useful technical tool in the treatment of complex, fusiform intracranial aneurysms.
Conference report SysMus 2016

Each year students from all over the world come together to share and discuss their knowledge on varying topics from the field of systematic musicology at the SysMus Conference. The 9th edition of this conference series, organised by students for students, took place in the idyllic town of Jyväskylä in Finland, and therefore for the first time in SysMus-history in one of the Nordic Countries. The 2016 conference was organised by student chairs Joshua Bamford and Susan Johnson with tremendous support from Birgitta Burger as supervising chair. With its international community and critically acclaimed researchers, SysMus 2016 proved to be a fruitful and exciting gathering.
Effect of Glutamine, Glutamic Acid and Nucleotides on the Turnover of Carbon (δ13C) in Organs of Weaned Piglets

Morphological and physiological alterations occur in the digestive system of weanling piglets, compromising the performance in subsequent phases. This experiment aimed at verifying the influence of glutamine, glutamate and nucleotides on the carbon turnover in the pancreas and liver of piglets weaned at 21 days of age. Four diets were evaluated: glutamine, glutamic acid or nucleotides-free diet (CD); containing 1% glutamine (GD); containing 1% glutamic acid (GAD) and containing 1% nucleotides (ND). One hundred and twenty-three piglets were utilized with three pigs slaughtered at day zero (weaning day) and three at each one of the experimental days (1, 2, 4, 5, 7, 9, 13, 20, 27, and 49 post-weaning), in order to collect organ samples, which were analyzed for the δ13C isotopic composition and compared by means of time. No differences were found (p>0.05) among treatments for the turnover of the 13C in the pancreas (T50% = 13.91, 14.37, 11.07, and 9.34 days; T95% = 46.22, 47.73, 36.79, and 31.04 days for CD, GD, GAD, and ND, respectively). In the liver, the ND presented accelerated values of carbon turnover (T50% = 7.36 and T95% = 24.47 days) in relation to the values obtained for the GD (T50% = 10.15 and T95% = 33.74 days). However, the values obtained for the CD (T50% = 9.12 and T95% = 30.31 days) and GAD (T50% = 7.83 and T95% = 26.03 days) had no differences (p>0.05) among other diets. The technique of 13C isotopic dilution demonstrated trophic action of nucleotides in the liver.
Critical Indigenous Literacies: Selecting and Using Children's Books about Indigenous Peoples

interchangeably, unless referring to a specific tribal nation. There are more than 500 federally recognized tribal nations in the United States today, each with distinct systems of governance, languages, locations, material cultures, religions, and, of course, stories! Some people are taken aback at the word “nation” as applied to Native nations because of the tendency to group Native peoples with other minority groups in the United States. However, that framework fails to encompass our single most important attribute: Native nationhood. Without this recognition, our status as sovereign nations whose people were— and are— Indigenous to this continent are erased. We were not the first Americans, since Native nations predate the United States of America by hundreds of years. In fact, European and then US leaders entered into diplomatic negotiations with leaders of Native nations who inhabited the lands from the beginning. The outcomes of those negotiations were treaties, much like the ones the United States forges with foreign nations today. Nonetheless, depictions of Native peoples as primitive or uncivilized are one of the reasons our nationhood is difficult to accept or understand. In fact, Native peoples had/have distinct in 1863, President lincoln issued a proclamation stating that the last Thursday of November would be a national day of thanksgiving. In 1990, President George H. W. Bush issued the first presidential proclamation that designated November as National Native American Heritage Month. With these two proclamations occurring in the same month, many teachers use November as the time to read aloud or assign children’s books that feature Native peoples. In this article, I ask teachers to rethink literature used to teach children about Indigenous peoples. In situating the experience of Native peoples across time, I begin with a clarification of terms. I am tribally enrolled at Nambé Pueblo, which means I am counted on the Nambé census. Most Native people prefer to name their specific tribal nation because being specific helps nonNative people learn that we are far more diverse than what the terms “American Indian” or “Native American” evoke. Historically, “Indian” was commonly used, but over time, more people began using “Native” instead. Most recently, “Indigenous” is emerging as an alternative, as seen in the movements to replace Columbus Day with Indigenous Peoples Day. I use the terms “Native” and “Indigenous”