Miracle-dz/UniFAR-FTUs huggingface dataset:
The Italian microbrewing experience: features and perspectives

The so-called Italian craft beer revolution is a new phenomenon characterised by a rapidly growing number of microbreweries and popularity of their products. The evolution of the Italian craft beer sector has interesting potentialities in terms of local/rural development. The analysis is based on available statistics as well as on a survey carried out in May 2014 which discloses features, motivations and expectations of the craft beer producers. Together with the risk of overproduction due to the high number of recent entries, the creation of local supply chains (from barley cultivation to its transformation into malt) is emerging as a possible evolution of the sector, thanks to the advent of a new typology of microbrewery, the agricultural brewery.
An open-label expanded access study of lapatinib and capecitabine in patients with HER2-overexpressing locally advanced or metastatic breast cancer.

BACKGROUND The Lapatinib Expanded Access Program (LEAP) was designed to provide access to lapatinib plus capecitabine for HER2-positive metastatic breast cancer patients who previously received an anthracycline, a taxane, and a trastuzumab and had no other treatment options. PATIENTS AND METHODS LEAP opened globally and enrollment continued until lapatinib received regulatory approval in each participating country. Patients were assessed for progression-free survival (PFS) and overall survival (OS) and monitored for serious adverse events (SAEs). RESULTS As of 30 September 2008, 4283 patients from 45 countries enrolled in LEAP. The median treatment duration was 24.7 weeks. The most common drug-related SAEs were diarrhea (9.7%), vomiting (4.3%), and nausea (2.4%) and were mainly grade 3 or higher. The incidences of special interest SAEs were decreased left ventricle ejection fraction (0.5%), interstitial lung disease/pneumonitis (0.2%), and serious hepatobiliary events (0.4%). This safety profile is consistent with the overall lapatinib program. The median PFS and OS were 21.1 [95% confidence interval (CI) = 20.1-22.3] and 39.6 (95% CI = 37.7-40.7) weeks, respectively (n = 4006). Subgroup analysis showed longer PFS and OS in patients who had not received prior capecitabine. CONCLUSIONS These results demonstrate the safety and efficacy of lapatinib in a broader patient population compared with a clinical trial.
Feeding Different Omega-3 Polyunsaturated Fatty Acid Sources Influences Renal Fatty Acid Composition, Inflammation, and Occurrence of Nephrocalcinosis in Female Sprague-Dawley Rats *

The general population is encouraged to increase omega-3 polyunsaturated fatty acid (n-3 PUFA) intake in order to optimize health for preventative health care. Consumers are typically unaware that different amounts, types, and structural forms of n-3 PUFA have different efficacy. Therefore, the objectives of this study were to characterize different sources of n-3 PUFAs and to determine whether consumption of these oils influences renal fatty acid composition and renal health. Lipid classes and fatty acid profile of corn (CO), flaxseed (FO), menhaden (MO), salmon (SO), tuna (TO) or krill (KO) oils were determined by thin-layer and gas chromatography. All dietary oils consisted of >65% triglyceride with the exception of KO. KO and FO also contained phospholipids. FO was rich in the n-3 PUFA, alpha-linolenic acid (18:3n-3) whereas, the marine oils were rich in the long-chain n-3 PUFAs (>18 carbons). Following characterization of the oil sources, female Sprague-Dawley rats (age 28 d) were randomly assigned (n = 10/group) to be fed a high fat 12% (wt) diet consisting of these different oil sources for 8 weeks. Rats fed MO, TO, and SO had significantly higher renal eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) deposition and this in turn, modulated inflammatory responses. Feeding rats MO, SO and TO reduced urinary excretion of 13,14-dihydro-15-keto prostaglandin E2. Feeding rats TO and SO reduced (P ≤ 0.002) nuclear factor kappa B activity and circulating TNFα (P P P < 0.001) urinary phosphorus excretion associated with the phospholipids content of KO. The study results indicated that consumption of n-3 PUFAs influences renal health and the effects varied depending on the n-3 PUFA source consumed.
neMEMSi: One step forward in wireless attitude and heading reference systems

This work presents neMEMSi, a novel MEMS based inertial and magnetic system-on-board with embedded processing and wireless communication capabilities, providing an ultra low-power and easy to use Attitude and Heading Reference System (AHRS). Main target applications are navigation systems and inertial based motion tracking technologies. The paper describes the architecture of neMEMSi and provides an evaluation of the performance in terms of key features of state-of-the-art AHRS.
Gd‐DTPA2− as a measure of cartilage degradation

Glycosaminoglycans (GAGs) are the main source of tissue fixed charge density (FCD) in cartilage, and are lost early in arthritic diseases. We tested the hypothesis that, like Na+, the charged contrast agent Gd‐DTPA2‐ (and hence proton T1) could be used to measure tissue FCD and hence GAG concentration. NMR spectroscopy studies of cartilage explants demonstrated that there was a strong correlation (r > 0.96) between proton T1 in the presence of Gd‐DTPA2‐ and tissue sodium and GAG concentrations. An ideal one‐compartment electrochemical (Donnan) equilibrium model was examined as a means of quantifying FCD from Gd‐DTPA2‐ concentration, yielding a value 50% less but linearly correlated with the validated method of quantifying FCD from Na+. These data could be used as the basis of an empirical model with which to quantify FCD from Gd‐DTPA2‐ concentration, or a more sophisticated physical model could be developed. Spatial distributions of FCD were easily observed in T1‐weighted MRI studies of trypsin and interleukin‐1 induced cartilage degradation, with good histological correlation. Therefore, equilibration of the tissue in Gd‐DTPA2‐ gives us the opportunity to directly image (through T1, weighting) the concentration of GAG, a major and critically important macromolecule in cartilage. Pilot clinical studies demonstrated Gd‐DTPA2‐ penetration into cartilage, suggesting that this technique is clinically feasible.
Reversibility of delirium in terminally ill patients and predictors of mortality

In this study, factors related to reversibility and mortality in consecutive cases of Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) delirium [n = 121] occurring in palliative care patients were evaluated. Delirium was assessed with the revised Delirium Rating Scale (DRS-R98) and Cognitive Test for Delirium (CTD). Patients were followed until recovery from delirium or death. In all, 33 patients (27%) recovered from delirium before death. Mean time until death was 39.7 ± 69.8 days in patients with reversible delirium [n = 33] versus 16.8 ± 10.0 days in those with irreversible delirium [n = 88; P < 0.01]. DRS-R98 and CTD scores were higher in irreversible delirium (P < 0.001) with greater disturbances of sleep, language, long-term memory, attention, vigilance and visuospatial ability. Irreversible delirium was associated with greater disturbance of CTD attention and higher DRS-R98 visuospatial function. Survival time was predicted by CTD score (P < 0.001), age (P = 0.01) and organ failure (P = 0.01). Delirium was not necessarily a harbinger of imminent death. Less reversible delirium involved greater impairment of attention, vigilance and visuospatial function. Survival time is related to age, severity of cognitive impairment and evidence of organ failure.
Measuring Search Retrieval Accuracy of Uncorrected OCR : Findings from the Harvard-Radcliffe Online Historical Reference Shelf Digitization Project

This report presents the findings of an investigation to evaluate the conditions for search retrieval successes and failures when using uncorrected OCR for indexing. The purpose of the study was to assess whether low-cost, high-production techniques for text conversion were adequate to produce digital reproductions of consistent quality and usability. We sought to identify attributes of the original material or the OCR-produced text that could predict when additional, costly processes (OCR correction or keying) would be needed to meet retrieval requirements for text digitization projects.
Closed-Cell Foam Skin Thickness Measurement Using a Scanning Electron Microscope

Abstract Closed cell polymer foam skin thickness can be assessed by taking backscatter electron (BSE) images in a scanning electron microscope (SEM) at a series of accelerating voltages. Under a given set of experimental conditions, the electron beam mostly passes through thin polymer skin cell walls. That cell appears dark compared to adjacent thicker-skinned cells. Higher accelerating voltages lead to a thicker skin being penetrated. Monte Carlo modeling of beam-sample interactions indicates that at 5 keV, skin less than ∼0.5 μm in thickness will appear dark, whereas imaging at 30 keV allows skin thicknesses up to ∼4 μm to be identified. The distribution of skin thickness can be assessed over square millimeters of foam surface in this manner. Qualitative comparisons of the skin thicknesses of samples can be made with a simple visual inspection of the images. A semiquantitative comparison is possible by applying image analysis. The proposed method is applied to two example foams. Characterizing foam skin thickness by this method is possible using any SEM that is capable of collecting useful BSE images over a range of accelerating voltages. Imaging in low vacuum, where an electrically conductive metal coating is not required, leads to more sensitivity in skin thickness characterization.
Nearfield Acoustical Holography Research & Application On Compressor & Refrigerator

Noise is one important factor for product performance of compressor & refrigerator. Products must satisfy with not only meeting the national standards but also the consumers’ gradually increasing requirements for sound quality because of market competition. Near field acoustical holography is a high-resolution imaging technique for reconstructing the vibro-acoustical field that will guide to locate noise source and understand the relationship between structure vibration and sound radiation. Near field acoustical holography method based on the Equivalent Source Method is applied to analyze the vibro-acoustical characteristics of both compressor and refrigerator. Equivalent Source Method is applicable for arbitrary shaped vibrating surface, presenting calculation faster than the Boundary Element Method, and better than the Helmholtz Equation Least Square Method, especially for elongated and planar sources. In virtue of this approach, velocity & sound pressure distribution over the sample geometry of compressor & refrigerator were gotten at critical frequencies, so main noise sources were located. 1. FOREWORDS
The Role of Research and Innovation in Promoting

Abstract Abstract Abstract This paper continues the empirical research line started by Crepon et al. (1998) about the impact of research and development on innovation and innovation on productivity of firms. In this paper we estimate a structural model using Asymptotic Least Squares (ALS) which corrects for selectivity and simultaneity biases taking in consideration the particular characteristics of the available data. We find that most of the Schumpeterian hypotheses are confirmed: research and innovative activities are related with firm size and market power. However, in the case of Chile, firms productivity is not affected by innovative results nor by research expenditures in the short run.
The impact of strategic human resource management on organizational resilience: an empirical study on hospitals

The aim of this study was to explore the impact of strategic human resource management practices (strategic value of human resource practices, human resource analytics and high-performance work practices) on organizational resilience (cognitive, behavioral and contextual dimensions) in private hospitals. The required data for the purpose of this study were collected by a questionnaire developed on the basis of related works. The questionnaire was developed based on exploratory and confirmatory factor analyses. It consisted of 30 items divided into two domains, the first one to measure strategic resource management practices (15 items), and the second one to measure organizational resilience (15 items). The study population was consisted of employees working at private hospitals. The questionnaires were distributed to a random sample of 500 administrative staff working in private hospitals. A total of 449 valid responses were retrieved with a response rate of 89.9%, which is high percent because the researcher visited the hospitals and distributed the questionnaires personally. Using IBM SPSS 24.0 and AMOS 22, the results confirmed that strategic human resource management practices have a positive impact on organizational resilience. In terms of the separate effects of strategic HRM practices, the results showed that strategic value of human resource practices was the most influential variable on organizational resilience, followed by human resource analytics, then high performance work practices The study concluded that the hospital’s ability to be resilient requires an advance planning when formulating the human resources strategy that is supposed to be integrated into the hospital’s strategy.
The Synergistic Effect of Daidzein and α-Tocopherol or Ascorbic Acid on Microsome and LDL Oxidation

WangH. ,�MartinM.W. ,�YinS. �(2010): The synergistic effect of daidzein and α-tocopherol or ascorbic acid on microsome and LDL oxidation. �CzechJ. �FoodSci. , 28:�385-391. Isoflavonedaidzein bringspotentialhealthbenefits. � Itsantioxidantpropertiesareconsideredtoberesponsible� inpartforitsprotectiveeffects. �Weinvestigatedtheantioxidanteffectsofdaidzeinanditsinteractiveeffectswith�� α-tocopherolorascorbicacidonFe 2+ /ascorbate-induced �oxidationofratlivermicrosomesandcopper-inducedhuman� low-densitylipoprotein �(LDL)�oxidation. �Althoughtheinhibitoryeffectofdaidzeinonlipidperoxidationinmicro - somewasweak, �iteffectivelypreventedLDLagainstoxidativemodificationbyprolongingthelagtime, �decreasing� thepropagatingrate, �andsuppressingmalonaldehyde �(MDA)�andcarbonylsformation. �Whendaidzeinwascombined� with �α-tocopherolinmicrosomesoxidationandwithascorbicacidinLDLoxidation, �theprotectionwassignificantly� greaterthanthecalculatedadditiveeffectofthetwoindividualactions. �Thus,�daidzeincanprotectLDLfromoxida - tivemodification, �anditscombinationwithnutrientsmaybesuperiortotheactionofitalone. �Theseresultscanhelp� togetabetterunderstandingoftheinteractionsofdifferentantioxidantsin vivo.
Methods of Reducing the Power Supply Outage Time of Rural Consumers

The chapter analyzes the power supply restoration time. The analysis shows that this time consists of the time for obtaining information about failure, the time of information recognition about failure, the damage repair time and the time of connection and disconnection harmonization. Each of them, in turn, is also considered in more detail that allows identifying reserves to reduce the power supply outage time. The chapter proposes reducing the power supply restoration time by going to the monitoring system combination of both operating modes and technical condition of power networks. Based on the study results, there are methods allowing to reduce the power supply outage time of rural consumers by means of automating rural electrical networks and improving the operating mode monitoring of power supply systems. The chapter also suggests a set of devices that allows to implement the proposed methods.
Diffusion Model for the Adoption of Smartphone Brands under Competitive Pricing

We extend the Bass diffusion model to capture the dynamic adoption and competitive pricing of two smartphone brands: Apple and Samsung. We use publicly available historical data to regress the model parameters. We find our model to reasonably fit the data, and we provide some insights on the competition between the smartphones brands with respect to our model and the available data.
MULTI-VERSION MUSIC SEARCH USING ACOUSTIC FEATURE UNION AND EXACT SOFT MAPPING

Research on audio-based music retrieval has primarily concentrated on refining audio features to improve search quality. However, much less work has been done on improving the time efficiency of music audio searches. Representing music audio documents in an indexable format provides a mechanism for achieving efficiency. To address this issue, in this work Exact Locality Sensitive Mapping (ELSM) is suggested to join the concatenated feature sets and soft hash values. On this basis we propose audio-based music indexing techniques, ELSM and Soft Locality Sensitive Hash (SoftLSH) using an optimized Feature Union (FU) set of extracted audio features. Two contributions are made here. First, the principle of similarity-invariance is applied in summarizing audio feature sequences and utilized in training semantic audio representations based on regression. Second, soft hash values are pre-calculated to help locate the searching range more
Consumer acceptace of mobile banking in Germany

Technological innovations in the banking industry, as well as the telecommunications industry have led to a growing trend in mobile banking worldwide. With Germany having a good foundation for mobile banking, the usage rate is noticeably lower than other Western countries. This study sought to investigate the slow rate of mobile banking acceptance in Germany by conducting a quantitative research. Empirical data was conducted through a questionnaire addressed to German inhabitants in order to determine the factors influencing the consumer’s behavioral intention toward mobile banking usage based on an extended version of the Technology Acceptance Model (TAM). The results of the questionnaire were analyzed with the IBM SPSS statistical tool in order to analyze consumer behavioral intention to use mobile banking. The findings of this study imply that the TAM can be used to analyze mobile banking acceptance in Germany. Perceived usefulness, perceived ease of use, personal innovativeness, social norms and relative advantages were found to have a positive affect on the usage, whilst perceived costs and perceived risk lead to a negative effect. The outcomes may provide insights to the mobile banking industry in Germany, for managers and developers to take into consideration when introducing a new service. This study could contribute to further research within the area of technological innovations.
Corporate Cultural Strategy in Human Resource Management Practice: Indonesia Perspective

This study explores the corporate culture strategic implemented by human resource manager to address those culture differences at the parent company, subsidiary company and individual. Semi-structured interviews are conducted with 8 HR managers in Indonesia.The corporate culture strategic include the degree of standardization of HR, industrial relationship, and geographic differences.To implement a corporate culture strategy in HR practice, the managers encourage stronger partnerships with the subsidiaries company, standardization of HRM practice, paying closer attention to changes in labor laws, cultural training and development, leadership development, and cultural awareness.
Question 2 : What do we know about the pathophysiology of prediabetes ?

Type 2 diabetes is a modern world-wide epidemic. Its complications are now a significant cause of morbidity and mortality in every European country and the consequences of its explosive growth are an intolerable burden both to the individual and to healthcare systems. The management of diabetes has become increasingly sophisticated over the past decade. Self management has been recognised and developed, there are now over a dozen pharmacological agents available to lower blood glucose (as well as blood pressure and dyslipidaemia), a multitude of ancillary supplies and equipment available, and there is a clear recognition by health care professionals and patients that diabetes is a serious disease. The normalization of blood glucose for any appreciable period of time, however, is seldom achieved. Even in well-controlled so-called “intensively” treated patients, serious complications still occur, and the economic and personal sequelae of diabetes remain [1-3]. Given these facts, it is not surprising that efforts have been initiated to determine the feasibility and benefit of various strategies to prevent or delay the onset of type 2 diabetes. Much of that effort has focused on what is now called “Pre-diabetes”. Already, a more accurate definition and intense study of pre-diabetes has led to some important insights: • Pre-diabetes is extremely common (as many as 40% of 40-74 year olds) [4] and needs to be addressed in clinical practice. • People with pre-diabetes are at high risk of developing diabetes and cardiovascular disease (CVD) and are the ideal target population for prevention programs. • There are safe, potentially effective interventions, which can affect modifiable risk factors. • Intensive lifestyle interventions are efficacious and should be encouraged but they may be difficult to broadly apply and sustain. • Effective pharmacological therapies have been identified to use in combination with these lifestyle interventions. The enormous impact of diabetes on public health, and the impressive progress made recently in understanding and treating pre-diabetes have encouraged the production of this paper. Managing pre-diabetes is the most cost effective way to avoid the many sequelae of diabetes and importantly the cardiovascular disease that comes with it. If left untreated most of these individuals will go on to develop type 2 diabetes within 10 years and a high proportion of them will suffer from microor macrovascular disease [5-7]. A group of European physicians, a diabetes specialist nurse, and patient representatives has reviewed key issues about the nature, identification and management of prediabetes in the Europe. They have agreed the available evidence for each question (reviewed here) and where no data is available a consensus of opinion has been provided.