Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploiting Temporal Information in Documents and Query to Improve the Information Retrieval Process: Application to Medical Articles

In the medical field, scientific articles represent a very important source of knowledge for researchers of this domain. But due to the large volume of scientific articles published on the web, an efficient detection and use of this knowledge is quite a difficult task. In this paper, we propose a novel method for semantic indexing of medical articles by using the semantic resource MeSH (Medical Subject Headings) and the temporal information provided in the documents. The proposed indexing approach was evaluated by intensive experiments. These experiments were conducted on document test collections of real world clinical extracted from scientific collections, namely, CISMEF and CLEF. The results generated by these experiments demonstrate the effectiveness of our indexing approach.
A 0.75-3.6GHz SiGe direct-conversion quadrature-modulator

A 0.75-3.6GHz SiGe direct-conversion quadrature-modulator has been implemented in 0.8/spl mu/m SiGe with integrated baluns in its RF-signal paths. Measured performance in 0.75-3.6GHz includes IRR better than -40dBc with output power levels in excess of -20dBm. For this performance circuit draws 46mA from a single 2.5V supply.
Parametric structural optimization with radial basis functions and partition of unity method

This paper presents the parametric approach of the structural optimization that combines the theory of radial basis function (RBF) interpolation and the partition of unity (POU) method. A surface is represented implicitly through a level function and its boundary is the zero level set, the evolution of the dynamic boundary is determined by the parameters of the RBF. In order to deal with these large point sets, we organize the point sets into some overlapping local sub-domains and reconstruct these local surfaces into the octree cells; POU method blends them into a global surface with higher numerical efficiency. Finally, we give the numerical examples to demonstrate the versatility of these methods.
Classifying Indonesian Online Articles as Advertisement Placement Base Using Text Mining

Rapid development in technological aspect resulting in growing level of human needs for the latest news, so that emerged a new trend of publishing and accessing news through online media or usually called online journalism. In addition, the number of people who sell and purchase through online sites also continues to increase and this opportunity is utilized by the company and the advertiser by implementing targeted web advertising. However, the high number of articles that have been published and accessed leads to great opportunities for errors in determining where to place the ads. Therefore, it needs a system that can categorize articles accessed by users as the basis of advertisement placement by the company and this classification system can be done by applying the method of Data Mining and Text Mining. This research uses document data in the form of article content that will be categorized into twenty categories of class of advertisement by using Text Mining technique with Support Vector Machine algorithm. The results of this study may be used by companies or advertisers as a basis for placement of ads on selected online media sites.
Distribution of cytokine gene polymorphisms in five Malay subethnic groups in Peninsular Malaysia

In this survey, we have successfully genotyped 22 single nucleotide polymorphisms in the 13 cytokine genes for five Malay subethnic groups (Kelantan, Acheh, Mandailing, Minangkabau and Patani Malays) using polymerase chain reaction–sequence‐specific primer cytokine genotyping kit (Invitrogen, Carlsbad, CA, USA). Most of the cytokine genes showed similar pattern of allelic spectra with wild‐type alleles (e.g. ILIa−889/C, ILIB+3962/C and IL6 nt565/G) that represent more than 80% in the studied Malay subethnic groups. These newly observed cytokine alleles and subsequent analyses clearly indicate genetic contribution from Asia in the studied Malay subethnic groups with evidence of admixture from neighbouring populations in Patani Malays. The cytokine data sets for the five Malay subethnic groups deposited in this report can also be used as reference standard for searching suitable donor for allograft transplant and diseases association study. This is particularly relevance as our analyses showed differences between the Malay subethnic groups and other populations screened for cytokine genes.
Uniform magnetic field of the planar coil with new winding structure for displacement-insensitive WPT

In near field wireless power transfer (WPT), the uniformity of magnetic field distribution near the transmitting coil is needed since it would affect the stability of transfer efficiency when the receiving coil is moving. In this paper, we proposed a new coil structure constructed of 3 or more spiral coils in series based on the relationship between current distribution and magnetic field distribution. Compared with previous literatures, this proposed coil can generate a more uniform magnetic field distribution.
Leptin Enhances TH2 and ILC2 Responses in Allergic Airway Disease*

Allergic asthma and obesity are the leading health problems in the world. Many studies have shown that obesity is a risk factor of development of asthma. However, the underlying mechanism has not been well established. In this study, we demonstrate that leptin, an adipokine elevated in obese individuals, promoted proliferation and survival of pro-allergic type 2 helper T cells and group 2 innate lymphoid cells and production of type 2 cytokines, which together contribute to allergic responses. Leptin activates mTORC1, MAPK, and STAT3 pathways in TH2 cells. The effects of leptin on TH2 cell proliferation, survival, and cytokine production are dependent on the mTORC1 and MAPK pathways as revealed by specific inhibitors. In vivo, leptin-deficiency led to attenuated experimental allergic airway inflammation. Our results thus support that obesity-associated elevation of leptin contributes to the increased susceptibility of asthma via modulation of pro-allergic lymphocyte responses.
p 13 suc 1 of Schizosaccharomyces pombe Regulates Two Distinct Forms of the Mitotic cdc 2 Kinase

suc1 is an essential gene initially identified for its ability to rescue certain temperature-sensitive alleles of cdc2 in Schizosaccharomyces pombe. The role of suc1 in the regulation of the cdc2 kinase is not well understood. In our study, we have characterized the biochemical effect of loss of suc1 function on specific cdc2-cyclin complexes. We show that the cig1 cyclin is associated with cdc2 and that the cdc2-cig1 kinase is activated at mitosis, with kinetics similar to those of the cdc2-cdc13 kinase. We provide evidence that loss of suc1 function affects the kinase activity of the two distinct mitotic forms of the cdc2 kinase. We also show that a dramatic increase in the level of the cdc13 protein is associated with loss of suc1. These results suggest that mitosis cannot be properly completed in the absence of suc1, possibly because of an increase in the level of cdc2-cdc13 complex, and support the idea of a role for suc1 in the regulation of multiple forms of the cdc2 kinase.
Correlates of Violent Assault Among Young Male Primary Care Patients

Correlates of violent assault (defined here as having been shot, stabbed, shot at, or beaten) were identified among young male primary care patients. Data were analyzed from a cohort of young men ages 17 to 29 during their initial visits to an urban primary care facility. Each underwent a clinical assessment, including a self-report health inventory and provider history. In multivariable analysis, history of incarceration (odds ratio [OR] = 6.29, 95 percent confidence interval [CI], 2.34-16.89), having children (OR = 3.06, 95 percent CI, 1.30-7.17), and a high school education or less (OR = 0.69, 95 percent CI, 0.50-0.96) were significantly associated with increased likelihood of violent assault. Patients reporting more serious traumatic experiences, such as incarceration, witnessing violence, or carrying a weapon, had the highest risk (OR = 9.91, 95 percent CI, 4.0-24.57). These findings may help primary care physicians identify young men at risk for violence and foster better interventions.
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain

Angiogenesis, the sprouting of new blood vessels from pre‐existing ones, is an essential physiological process in development, yet also plays a major role in the progression of human diseases such as diabetic retinopathy, atherosclerosis and cancer. The effects of the most potent angiogenic factors, vascular endothelial growth factor (VEGF), angiopoietin and fibroblast growth factor (FGF) are mediated through cell surface receptors that possess intrinsic protein tyrosine kinase activity. In this report, we describe a synthetic compound of the pyrido[2,3‐d]pyrimidine class, designated PD 173074, that selectively inhibits the tyrosine kinase activities of the FGF and VEGF receptors. We show that systemic administration of PD 173074 in mice can effectively block angiogenesis induced by either FGF or VEGF with no apparent toxicity. To elucidate the determinants of selectivity, we have determined the crystal structure of PD 173074 in complex with the tyrosine kinase domain of FGF receptor 1 at 2.5 resolution. A high degree of surface complementarity between PD 173074 and the hydrophobic, ATP‐binding pocket of FGF receptor 1 underlies the potency and selectivity of this inhibitor. PD 173074 is thus a promising candidate for a therapeutic angiogenesis inhibitor to be used in the treatment of cancer and other diseases whose progression is dependent upon new blood vessel formation.
Toughness of heterogeneous polymeric systems : a modeling approach

• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
Extraktion von semantischen Relationen aus natürlichsprachlichem Text mit Hilfe von maschinellem Lernen

Zusammenfassung: Inhalt der vorliegenden Arbeit ist die Entwicklung eines Lernverfahrens, das aus großen Textkorpora semantische Relationen automatisch extrahiert. Den Kern des Verfahrens bildet die Iteration von Suchschritt und Verifikationsschritt, in denen in gesuchter Relation stehende Wörter gefunden und überprüft werden. Auf diese Weise ist es möglich, mit wenigen bekannten Wörtern eine große Anzahl in derselben Relation stehende Wörter zu gewinnen. So können mit wenig Aufwand große Listen von Wörtern erstellt werden, die in einem semantischen Zusammenhang stehen. Nach der Skizzierung des Algorithmus werden theoretische Vorhersagen bezüglich der für das Verfahren geeigneten Relationen getroffen, sowie der Ablauf modelliert. Einige mit einer Implementierung des Verfahrens erzielte Ergebnisse werden für die Relation der Personennamen vorgestellt, evaluiert und diskutiert, des Weiteren werden Ausblicke und Verbesserungsmöglichkeiten angegeben.
MULTIFOCAL ELECTRORETINOGRAM IN BIRDSHOT CHORIORETINOPATHY

Purpose: To characterize multifocal electroretinogram parameters in patients with birdshot chorioretinopathy. Methods: Twenty-eight patients with birdshot chorioretinopathy consecutively included from 2006 to 2011 were matched to 27 healthy subjects for age, axial length, and lens status. Multifocal electroretinogram was prospectively evaluated using the Vision Monitor system. Results: Birdshot chorioretinopathy eyes differed significantly from healthy eyes by a decrease in mean root mean square values (−24.7%), P1 (−17.3%) and N2 (−27.5%) amplitude, and the P1/N1 ratio (−26.3%) as well as an increase in N1 (8.7%) and P1 (5.4%) implicit time (IT). An effect of the degree of eccentricity (5 zones) was found for root mean square (P < 0.001), P1 (P < 0.001) and N2 (P < 0.001) amplitude, and P1 IT (P < 0.001). Root mean square, the P1/N1 ratio, P1 and N2 amplitudes, P1 and N1 ITs were significantly correlated with visual acuity, mean defect of visual field, foveal threshold, and color vision score. The fluorescein angiographic score was significantly correlated to N1 and N2 amplitudes and N1 IT. Conclusion: Amplitudes and ITs of the multifocal electroretinogram parameters are impaired in patients with birdshot chorioretinopathy and are well correlated with other anatomical and functional tests. Periodic testing could guide the immunosuppressive treatment.
Technological complexity and the evolving structure of MNC subsidiary knowledge accumulation

The paper analyses the implications of increasing technological complexity and organizational restructuring for the knowledge accumulation activities of the subsidiaries of multinational corporations (MNCs). An analysis of foreign-owned subsidiaries in the German pharmaceutical industry in 1975-1995 indicates that the restructuring and intensification of knowledge exchange mechanisms in MNCs are an essential factor to enable subsidiaries to play a more creative role in knowledge generation. Although subsidiaries might use internal and external knowledge networks in their knowledge accumulation process in a complementary way, the purposes differ. In particular, the international internal knowledge networks of subsidiaries have been used increasingly for incremental knowledge building within the same field, whereas local external knowledge networks have been used far more for transferring more technologically complex knowledge.
The Effect of Brand Management and Product Quality on Firm Performance: The Italian Craft Brewing Sector

ABSTRACT The article contributes to the limited literature on marketing strategies of microfirms operating in new niches within mature industries. The study explores the effect of brand management processes and product quality on performance of microfirms in the Italian brewing industry. Preliminary qualitative interviews with eight entrepreneurs were realized. Then 92 questionnaires were collected from the entire population of 335 microbreweries operating in Italy for quantitative analysis. Findings suggest intrinsic product quality being the most relevant determinants of firms’ performance, while the adoption of brand management processes exerts a significant, negative impact. The article takes into account the relationship between brand management, quality, and performance by focusing on a single industry. Future research may enhance the significance of our findings by including multiple sectors. Entrepreneurs and microbusiness leaders should carefully assess both external (industry life-cycle stage) and internal (resource availability) factors before engaging in any brand management activity. In mature firms, it may be more beneficial and effective focusing on enhancing product quality. The article addresses an important gap regarding the adoption of brand management practices in microfirms, adding to the emerging strategic marketing literature in the small business field.
Rapid transformation of high cellulase‐producing mutant strains of Trichoderma reesei by microprojectile bombardment

Intact conidia of three industrially relevant strains of Trichoderma reesei were effectively transformed by particle bombardment. Transformations were carried out individually with plasmids carrying either the fungal amdS or bacterial hph gene as a selectable marker and by cotransformation with both plasmids. Transformant yields with single plasmids were up to 11 stable transformants per µg DNA at the bombardment distance of 6 cm. Mitotic stability of the transformants was 75–100% and the cotransformation efficiency averaged 92% when the first selection was performed on hygromycin B plates. The entire procedure could be completed in 1 week with the hph marker.
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation

Exposure to short-wavelength UV light (UVC) strongly induces p53 expression. In human RKO colorectal carcinoma cells, this increase was not due to elevated p53 mRNA abundance, cytoplasmic export of p53 mRNA, or UVC-triggered stabilization of the p53 protein. Instead, p53 translation was potently enhanced after UVC irradiation. The 3′ UTR of p53 was found to be a target of the RNA-binding protein HuR in a UVC-dependent manner in vitro and in vivo. HuR-overexpressing RKO cells displayed elevated p53 levels, whereas cells expressing reduced HuR showed markedly diminished p53 abundance and p53 translation. Our results demonstrate a role for HuR in binding to the p53 mRNA and enhancing its translation.
Inflammatory potential of diet and risk for hepatocellular cancer in a case–control study from Italy

Abstract Inflammation and diet have been suggested to be important risk factors for hepatocellular cancer (HCC). This Italian multicentre hospital-based case–control study conducted between 1999 and 2002 and including 185 cases with incident, histologically confirmed HCC, and 404 controls hospitalised for acute non-neoplastic diseases provided an opportunity to investigate the association between HCC and the dietary inflammatory index (DII). The DII was computed on the basis of dietary intake assessed 2 years before the date of interview by a validated sixty-three-item FFQ. Logistic regression models were used to estimate OR adjusted for age, sex, study centre, education, BMI, smoking, physical activity, serum markers of hepatitis B and C infection and energy intake. Energy adjustment for DII was performed using the residual method. Participants in the highest tertile of DII scores (i.e. with a more pro-inflammatory diet) had a higher risk for HCC (ORtertile 3 v, 1 2·43; 95 % CI 1·27, 4·68; P trend=0·03). When stratified by the presence or absence of hepatitis B/C infection and sex, DII was strongly associated with HCC in hepatitis B- and C-negative participants (ORtertile 3 v. 1 4·18; 95 % CI 1·53, 11·39; P trend=0·02) and among males (ORtertile 3 v. 1 3·60; 95 % CI 1·65, 7·87; P trend=0·001). These results indicate that a pro-inflammatory diet is associated with increased risk for HCC, in those without a history of hepatitis B/C infection and among males.
Community-based screening for chronic kidney disease, hypertension and diabetes in Dharan.

INTRODUCTION Nepal cannot afford renal replacement therapy for End Stage Renal Disease due to lack of resources. Early diagnosis of Chronic Kidney Disease and its risk factors may reduce the need of renal replacement therapy. METHODS A community-based screening on, 3218 people ≥20 years were assessed by door-to-door survey in Dharan, Nepal. Health status, lifestyle habit, physical examination and blood pressure were evaluated. Spot urine was examined for proteins and glucose by dipstick. Fasting blood glucose and serum creatinine were measured in a subset of 1000 people and the prevalence of Chronic Kidney Disease was evaluated. RESULTS Overweight, obesity, hypertension, diabetes and proteinuria were found in 20%, 5.0%, 38.6%, 7.5%, and 5.1% respectively. In the subset group, Chronic Kidney Disease was detected in 10.6%. Multivariate analysis indicated age (P <0.0001) and diabetes (P = 0.027) as statistically significant predictors for Chronic Kidney Disease. Total of 848 patients entered the management program of lifestyle modification and pharmacologic intervention. Glycemic and blood pressure control was achieved in 60% and 72%, respectively. Regression or stabilization of proteinuria was reported in 52% of patients. CONCLUSIONS Burden of Chronic Kidney Disease and cardiovascular risk factors are high in Dharan. Reasonable control of blood sugar, hypertension and proteinuria was achieved in this program. Findings indicate that activation a large prevention and intervention program to tackle Chronic Kidney Disease and Cardiovascular Disease in Nepal is needed.
Template‐based docking of a prolactin receptor proline‐rich motif octapeptide to FKBP12: Implications for cytokine receptor signaling

A conserved proline‐rich motif (PRM) in the cytoplasmic domain of cytokine receptors has been suggested to be a signaling switch regulated by the action of the FK506 binding protein (FKBP) family of peptidylprolyl isomerases (O'Neal KD, Yu‐Lee LY, Shearer WT, 1995, Ann NY Acad Sci 766:282–284). We have docked the prolactin receptor PRM (Ile1‐Phe2‐Pro3‐Pro4‐Val5‐Pro6‐Gly7‐Pro8) to the ligand binding site of FKBP12. The procedure involved conformational search restricted by NMR restraints (O'Neal KD et al., 1996, Biochem J 315:833–844), energy minimization of the octapeptide conformers so obtained, template‐based docking of a selected conformer to FKBP12, and energy refinement of the resulting complex. The template used was the crystal structure of a cyclic FK506‐peptide hybrid bound to FKBP12. Val5‐Pro6 of the PRM was taken to be the biologically relevant Xaa‐Pro bond. The docked conformer is stabilized by two intramolecular hydrogen bonds, N7H7 → O4 and N2H2 → O8, and two intermolecular ones, Ile56: N‐H → O=C:Pro6 and Tyr82:O‐H → O=C:Gly7. This conformer features a Type I β‐turn and has extensive hydrophobic contacts with the FKBP12 binding surface. The observed interactions support the hypothesis that FKBP12 catalyzes cis‐trans isomerization in the PRM when it is part of the longer cytoplasmic domain of a cytokine receptor, and suggest a significant role for the PRM in signal transduction.
The Legitimacy of Institutional Theory: The Case of CSR Reporting in Cross-Cultural Settings

This paper puts forward an argument that cultural factors interact with the institutional structures of organizations; and thus influence their CSR reporting system. Observations on 403 annual reports, corporate websites and CSR stand-alone reports of 203 companies in China, Malaysia, India and the UK support the argument. The results show that in China, both the quality and quantity of CSR disclosure increase significantly with the existence of CSR board committees, where the culture is one of collectivism, rather than of individualism. The paper also demonstrated that government-owned companies in Malaysia provide CSR disclosure of a quality higher than non-government owned companies. A similar relationship does not apply to companies in other countries. The results testify to institutional theory — that CSR reporting is influenced by the organizational settings of a country and the culture of a country. For policy makers, it is suggested that CSR reporting policy should be drafted in a way that suits the local culture.
2 Reinforcement Learning 2 . 1 Markov Decision Processes

We introduce a new class of Reinforcement Learning algorithms designed to operate in perceptual spaces containing images. They work by classifying the percepts using a computer vision algorithm specialized in image recognition, hence reducing the visual percepts to a symbolic class. This approach has the advantage of overcoming to some extent the curse of dimensionality by focusing the attention of the agent on distinctive and robust visual features. The visual classes are learned automatically in a process that only relies on the reinforcement earned by the agent during its interaction with the environment. In this sense, the visual classes are learned interactively in a task-driven fashion, without an external supervisor. We also show how our algorithms can be extended to perceptual spaces, large or even continuous, upon which it is possible to define features.