Miracle-dz/UniFAR-FTUs huggingface dataset:
Generalized Models on Self-Decoupled Dual Pick-up Coils for Large Lateral Tolerance

Self-decoupled dual pick-up coils for large lateral tolerance and low electromagnetic field for pedestrians are proposed. Analytical models are developed that are applicable to any self-decoupled coils, regardless the coil types such as single/dual pick-ups and core/coreless coils. An optimum decoupling distance between adjacent pick-up coils is determined and found to be independent of the existence of a core plate. Maximum load power over a large lateral tolerance is obtained for the optimum decoupling distance. The proposed models are so general that they can be applied to any self-decoupled pick-up coils for stationary charging and dynamic charging systems. Moreover, the self-decoupled coils are compatible with any compensation method such as serial, parallel, and serial-parallel. A prototype system of 1.5 kW and Q = 60 for roadway powered electrical vehicles was implemented and showed fairly good agreements with the theoretical models and simulations. The measured lateral tolerance was 90 cm, which is about 1.5 times of the coil width.
Differences in the perceptions of farmers and veterinary surgeons about the efficacy of mitigation strategies for controlling bluetongue

This study used adaptive conjoint analysis to quantify veterinary surgeons' and farmers' perceptions of a number of previously identified, viable mitigation strategies for controlling bluetongue. Data were collected using a questionnaire survey and face-to-face interviews. A total of 178 completed questionnaires were collected, 121 from farmers and 57 from veterinary surgeons. There were strong significant differences between the strength of preference of farmers and veterinary surgeons for a number of strategies. There was also large variation in the strength of preference among veterinary surgeons with respect to options involving vaccination. The results suggest uncertainty among both veterinary surgeons and farmers regarding the efficacy of current strategies, and suggest the need for dissemination of information to veterinary surgeons and farmers to be better coordinated.
Partial discharge. III. Cavity-induced PD in solid dielectrics

For pt.II see ibid., vol.6, no.5, p.35 et seq. (1990). The question of how to relate the magnitude of the measured, effective, partial discharge (PD) to the size, shape, and position of the cavity within a solid dielectric system is addressed. The causes of cavities are examined, and a brief review of gas breakdown is given. It is then shown that for a range of geometries, such as parallel plate and coaxial, one can develop analytic solutions (i.e. formulas), and that for any system the solution can be found using computer-based methods for calculating the electric field throughout a sample. Scaling rules are derived from the physical model. <<ETX>>
Adenovirus-Mediated Expression of a Ribozyme to c-mybmRNA Inhibits Smooth Muscle Cell Proliferation and Neointima Formation In Vivo

ABSTRACT Smooth muscle cell (SMC) proliferation is an important component of restenosis in response to injury after balloon angioplasty. Inhibition of proliferation in vivo can limit neointima hyperplasia in animal models of restenosis. Ribozymes against c-myb mRNA have been shown to be effective inhibitors of SMC proliferation in vitro. The effectiveness of adenovirus as a gene therapy vector in animal models of restenosis is well documented. In order to test the utility of ribozymes to inhibit SMC proliferation by a gene therapy approach, recombinant adenovirus expressing ribozymes against c-mybmRNA was generated and tested both in vitro and in vivo. This adenovirus ribozyme vector is shown to inhibit SMC proliferation in culture and neointima formation in a rat carotid artery balloon injury model of restenosis.
Annual Scientific Meeting of ASCEPT 2003 IDENTIFICATION AND CHARACTERIZATION OF THE MOUSE AND RAT RELAXIN RECEPTORS AS THE NOVEL ORTHOLOGUES OF HUMAN LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN-COUPLED RECEPTOR 7

SUMMARY 1. Relaxin is an extracellular matrix (ECM)-remodellinghormone that is functionally important in reproductive tissues,brain, lung and heart.2. Recently, the human relaxin receptor was identiﬁed asleucine-rich repeat-containing G-protein-coupled receptor 7(LGR7). 3. Using human LGR7 as a template, we identiﬁed mouseand rat LGR7 orthologues in the Celera and National Centrefor Biotechnology Information databases.4. At the protein level, mouse and rat LGR7 share 85.2 and85.7% identity with human LGR7, respectively.5. Mouse LGR7 mRNA was detected in all tissues whererelaxin binding is observed.6. Mouse and rat LGR7 bound [ 33 P]-relaxin with highafﬁnity and, upon relaxin treatment, both receptors stimulatedcAMP production in transfected HEK 293T cells.7. These results indicate that mouse and rat LGR7 are therelaxin receptors in these species.8. The actions of relaxin in rodents are well characterized,providing an established platform for research into themolecular pharmacology of the highly conserved relaxinreceptor.Key words: extracellular matrix, insulin-like peptide 3(INSL3), insulin-like peptides, leucine-rich repeat-containingG-protein-coupled receptor 7 (LGR7), pregnancy, relaxin.
Malware detection using Markov Blanket based on opcode sequences

Generally malwares are defined as security threat for computing systems and computer networks. Today's common and most used method for detecting malwares is signature-based method. There is also another way that focuses on file behavior. More over, recent researches used data mining and machine learning and other heuristic solutions for malware detection. In the current research, new method based on opcode sequences extraction has been introduced. Markov Blanket Algorithm has been used as a feature selection method to reduce the number of features. Using Markov Blanket reduced features size about 99%. Finally, a Hidden Markov Model has been trained based on the best features. Experimental results revealed that the trained model detects malwares with about 99% precision and 98% sensitivity.
Surface-enhanced Raman scattering on tunable plasmonic nanoparticle substrates

Au and Ag nanoshells are investigated as substrates for surface-enhanced Raman scattering (SERS). We find that SERS enhancements on nanoshell films are dramatically different from those observed on colloidal aggregates, specifically that the Raman enhancement follows the plasmon resonance of the individual nanoparticles. Comparative finite difference time domain calculations of fields at the surface of smooth and roughened nanoshells reveal that surface roughness contributes only slightly to the total enhancement. SERS enhancements as large as 2.5 × 1010 on Ag nanoshell films for the nonresonant molecule p-mercaptoaniline are measured.
A Social Network Analysis methods based on ontology

Social Network Analysis mainly make use of graph theory and matrix technology to analyze relationship data, but relationships are various and different, the edges in the graph or the numerical values in the matrix are incapable of express the plentiful semantics that the relationships. In this paper, a social network analysis method based on ontology is proposed, which can describe the semantic of relationship. We create the relationship ontology, and illuminate the attribute and constraints of ontology, so the computer can know the relationship semantic and implement the reasoning.
The N-terminal Structure of HIV-1 Tat Is Required for Suppression of CD26-dependent T Cell Growth*

Evidence exists that the human immunodeficiency virus-1 (HIV-1) transactivator Tat occurs extracellularly and is involved in the immunosuppression of non-HIV-1-infected T cells of acquired immunodeficiency syndrome (AIDS) patients. The mechanism of this immunosuppressive activity of Tat has been controversially discussed. Interestingly, Tat binds to the T cell activation marker CD26, which has been shown to play a key role in the regulation of growth of lymphocytes and to inhibit its dipeptidyl peptidase IV (DP IV) activity. Here we show that the N-terminal nonapeptide MDPVDPNIE of Tat is a competitive inhibitor of DP IV and suppresses DNA synthesis of tetanus toxoid-stimulated peripheral blood mononuclear cells. Amino acid exchanges at positions 5 and 6 strongly weaken these effects.1H nuclear magnetic resonance and molecular dynamics simulations of Tat(1–9), I5-Tat(1–9), and L6-Tat(1–9) suggest a similar backbone conformation for Tat(1–9) and L6-Tat(1–9). The solution conformation of I5-Tat(1–9) considerably differs from the other two. However, Tat(1–9) fits into our previously proposed active site model of DP IV in contrast to I5-Tat(1–9) and L6-Tat(1–9). Conformational alterations with regard to the parent peptide and spatial hindrances between these both compounds and DP IV can explain the loss of inhibitory activity. Our data suggest that the N-terminal residues of HIV-1 Tat do interact directly with the active site of DP IV and that DP IV does mediate Tat’s immunosuppressive effects.
Regulation of Epstein–Barr virus reactivation from latency

The Epstein–Barr virus (EBV) is a human gamma‐herpesvirus that is implicated in various types of proliferative diseases. Upon infection, it predominantly establishes latency in B cells and cannot ever be eradicated; it persists for the host's lifetime. Reactivation of the virus from latency depends on expression of the viral immediate‐early gene, BamHI Z fragment leftward open reading frame 1 (BZLF1). The BZLF1 promoter normally exhibits only low basal activity but is activated in response to chemical or biological inducers, such as 12‐O‐tetradecanoylphorbol‐13‐acetate, calcium ionophore, histone deacetylase inhibitor, or anti‐Ig. Transcription from the BZLF1 promoter is activated by myocyte enhancer factor 2, specificity protein 1, b‐Zip type transcription factors and mediating epigenetic modifications of the promoter, such as histone acetylation and H3K4me3. In contrast, repression of the promoter is mediated by transcriptional suppressors, such as ZEB, ZIIR‐BP, and jun dimerization protein 2, causing suppressive histone modifications like histone H3K27me3, H3K9me2/3 and H4K20me3. Interestingly, there is little CpG DNA methylation of the promoter, indicating that DNA methylation is not crucial for suppression of BZLF1. This review will focus on the molecular mechanisms by which the EBV lytic switch is controlled and discuss the physiological significance of this switching for its survival and oncogenesis.
A Dual Pressure Linear Ion Trap Orbitrap Instrument with Very High Sequencing Speed*

Since its introduction a few years ago, the linear ion trap Orbitrap (LTQ Orbitrap) instrument has become a powerful tool in proteomics research. For high resolution mass spectrometry measurements ions are accumulated in the linear ion trap and passed on to the Orbitrap analyzer. Simultaneously with acquisition of this signal, the major peaks are isolated in turn, fragmented and recorded at high sensitivity in the linear ion trap, combining the strengths of both mass analyzer technologies. Here we describe a next generation LTQ Orbitrap system termed Velos, with significantly increased sensitivity and scan speed. This is achieved by a vacuum interface using a stacked ring radio frequency ion guide with 10-fold higher transfer efficiency in MS/MS mode and 3–5-fold in full scan spectra, by a dual pressure ion trap configuration, and by reduction of overhead times between scans. The first ion trap efficiently captures and fragments ions at relatively high pressure whereas the second ion trap realizes extremely fast scan speeds at reduced pressure. Ion injection times for MS/MS are predicted from full scans instead of performing automatic gain control scans. Together these improvements routinely enable acquisition of up to ten fragmentation spectra per second. Furthermore, an improved higher-energy collisional dissociation cell with increased ion extraction capabilities was implemented. Higher-collision energy dissociation with high mass accuracy Orbitrap readout is as sensitive as ion trap MS/MS scans in the previous generation of the instrument.
Is coffee consumption associated with a lower level of serum C-reactive protein? A meta-analysis of observational studies

Abstract The association between coffee consumption and the level of C-reactive protein (CRP) has been evaluated in several epidemiological studies with conflicting results. This study aims to examine the relationship between coffee consumption and the serum CRP level. A comprehensive literature search up to August 2017, using PUBMED, EMBASE and Web of Science databases, was conducted to identify the relevant observational studies that examined the association between coffee consumption and the serum CRP level. A total of nine cross-sectional studies were included in this meta-analysis. According to the combined standard mean difference (SMD) between the highest and the lowest coffee intake category, coffee consumption was associated with a lower level of serum CRP level (SMD = −0.34, 95%CI: −0.62 to −0.06; p = .016). Subgroup analysis for CRP marker showed that coffee consumption was associated with a lower level of serum high-sensitivity CRP (hsCRP) (SMD = −0.51, 95%CI: −0.88 to −0.14; p = .007), but not standard CRP (SMD = 0.02, 95%CI: −0.28 to 0.32; p = .913). The existing evidence suggested that coffee consumption was associated with a lower level of serum CRP. More well-designed prospective cohort studies are needed to elaborate the concerned issues further.
Predictors of smoking cessation among adult smokers in Malaysia and Thailand: findings from the International Tobacco Control Southeast Asia Survey.

INTRODUCTION Limited longitudinal studies on smoking cessation have been reported in Asia, and it remains unclear whether determinants of quitting are similar to those found in Western countries. This study examined prospective predictors of smoking cessation among adult smokers in Thailand and Malaysia. METHODS Four thousand and four smokers were surveyed in Malaysia and Thailand in 2005. Of these, 2,426 smokers were followed up in 2006 (61% retention). Baseline measures of sociodemographics, dependence, and interest in quitting were used to predict both making quit attempts and point prevalence maintenance of cessation. RESULTS More Thai than Malaysian smokers reported having made quit attempts between waves, but among those who tried, the rates of staying quit were not considerably different between Malaysians and Thais. Multivariate analyses showed that smoking fewer cigarettes per day, higher levels of self-efficacy, and more immediate quitting intentions were predictive of both making a quit attempt and staying quit in both countries. Previous shorter quit attempts and higher health concerns about smoking were only predictive of making an attempt, whereas prior abstinence for 6 months or more and older age were associated with maintenance. DISCUSSION In Malaysia and Thailand, predictors of quitting activity appear to be similar. However, as in the West, predictors of making quit attempts are not all the same as those who predict maintenance. The actual predictors differ in potentially important ways from those found in the West. We need to determine the relative contributions of cultural factors and the shorter history of efforts to encourage quitting in Asia.
Renal Vascular Effects of Dilazep Antagonized by 3‐Isobutyl‐1‐Methyl‐Xanthine

Summary: The effects of different doses of dilazep on renal hemodynamics, urine formation, and renin release were studied in anesthetized dogs. Intrarenal arterial infusion of dilazep (1 μg/kg/min) increased renal blood flow, with no change in systemic arterial blood pressure and renal venous plasma renin activity. Renal vasodilation induced by dilazep was completely inhibited by intrarenal arterial infusion of 3-isobutyl-1-methyl-xanthine (IBMX; 11.1 μg/kg/min), a potent adenosine receptor antagonist, but not by indomethacin (13 mg/kg i.v.). These results suggest that dilazep has a vasodilatory action in the kidney—one that is independent of the renal renin-angiotensin system. The inhibitory action of IBMX on the dilazep-induced renal vasodilation indicates that the renal vascular effects of dilazep may be exerted by augmentation of endogenous adenosine and mediated through adenosine receptors.
Hydrodynamic and Spectroscopic Studies of Substrate Binding to Human Recombinant Deoxycytidine Kinase

Abstract Deoxycytidine kinase (dCK), a cytosolic enzyme with broad substrate specificity, plays a key role in the activation of therapeutic nucleoside analogues by their 5′-phosphorylation. The structure of human dCK is still not known and the current work was undertaken to determine its oligomeric and secondary structure. Biophysical studies were conducted with purified recombinant human dCK. The Mr determined by low-speed sedimentation equilibrium under nondenaturing conditions was 60,250 ± 1,000, indicating that dCK, which has a predicted Mr of 30,500, exists in solution as a dimer. Analysis of circular dichroism spectra revealed the presence of two negative dichroic bands located at 222 and 209 nm with ellipticity values of –11,900 ± 300 and −12,500 ± 300 deg·cm2·dmol−1, respectively, indicating the presence of approximately 40% α-helix and 50% β-structure. Circular Dichroism studies in the aromatic and far-ultraviolet range and UV difference spectroscopy indicated that binding of substrates to dCK reduced its α-helical content and perturbed tryptophan and tyrosine. Steady-state fluorescence demonstrated that deoxycytidine (the phosphate acceptor) and ATP (the phosphate donor) bound to different sites on dCK and fluorescence quenching revealed bimodal binding of deoxycytidine and unimodal binding of ATP. Spectroscopic studies indicated that substrate binding induced conformational changes, with the result that dCK exhibited different affinities for various substrates. These results are consistent with a random bi-bi kinetic mechanism of phosphorylation of dCyd with either ATP or UTP.
An Empirical Analysis of Reputation,Wealth and Rural Credit Rationing:Study on the Supply Behavior of Different Rural Financial Organizations in Less-developed Areas

Based on the survey data of about 800 rural households in Yunnan province and Ningxia province in 2006,the paper makes an empirical study on the credit supply behavior of rural financial organizations in less-developed areas.By differentiating between notional demand and effective demand,it indicates that rural cooperatives and banks favor the rich rural households.But informal financial organizations do not make a distinction between poor rural households and rich ones,so they cover more areas than formal financial organizations.Both of formal and informal financial organizations attach the great significance to the reputation of rural households,but the credit record is not shared.These difference stems from different information costs and transaction costs of financial organizations.
Aggregation Model-Based Optimization for Electric Vehicle Charging Strategy

This paper presents an aggregation charging model for large numbers of electric vehicles (EVs). A genetic algorithm (GA) is employed to obtain the stochastic feature parameters of the aggregation model, and a charging strategy based on the aggregation model is developed to reduce the power fluctuation level caused by EV charging. In addition, an updatable optimization method is proposed to track the variation of the EV charging characteristics. The proposed charging strategy and optimization method are validated by the simulation results.
Accurate Determination of S-Phase Fraction in Proliferative Cells by Dual Fluorescence and Peroxidase Immunohistochemistry with 5-Bromo-2′-Deoxyuridine (BrdU) and Ki67 Antibodies

To ensure the maintenance of tissues in mammals, cell loss must be balanced with cell production, the proliferative activity being different from tissue to tissue. In this article, the authors propose a new method for the quantification of the proliferative activity, defined as the S-phase fraction of actively cycling cells, by dual labeling with fluorescence and peroxidase immunohistochemistry using BrdU (marker of S-phase) and Ki67 antibodies (marker of G1-, S-, G2-, and M-phases) after a one-step antigen retrieval. In the generative cell zones of fundic and pyloric glandular stomachs, where the majority of cells were cycling, the authors measured a proliferative activity of 31%. In the epithelium of the forestomach and the skin, where cycling cells are intermingled with G0 and differentiated cells, proliferative activities were 21% and 13%, respectively. In the adrenal cortex, in which cycling cells were sparsely distributed, the proliferative activity reached 32%. During the regenerative process in the skin after a lesion, the proliferative activity increased in proximity to the wound. The present one-step dual-labeling method has revealed that the proliferative activity is different between tissues and depends on the physiological or pathological state.
Golf swing motion detection using an inertial-sensor-based portable instrument

This paper presents an inertial-sensor-based portable instrument and its associated swing motion detection algorithm to detect the following several major stages of a full golf swing motion: address, back swing, top of swing, down swing, impact, follow through, and finish. The portable instrument consisting of a microcontroller, a triaxial accelerometer, a triaxial gyroscope, and a Bluetooth wireless transmission module can be mounted on the golf club to measure swing motion signals. A swing motion detection algorithm composed of the procedures of signal collection, signal preprocessing, and swing motion segmentation has been developed for recognizing golf swing motion stages. Experimental results show that the portable instrument with its swing motion detection algorithm is a promising tool for serving as a training assistant tool for golfers.
Ciliary Neurotrophic Factor Activates Spinal Cord Astrocytes, Stimulating Their Production and Release of Fibroblast Growth Factor-2, to Increase Motor Neuron Survival

At focal CNS injury sites, several cytokines accumulate, including ciliary neurotrophic factor (CNTF) and interleukin-1beta (IL-1beta). Additionally, the CNTF alpha receptor is induced on astrocytes, establishing an autocrine/paracrine loop. How astrocyte function is altered as a result of CNTF stimulation remains incompletely characterized. Here, we demonstrate that direct injection of CNTF into the spinal cord increases GFAP expression and astroglial size and that primary cultures of spinal cord astrocytes treated with CNTF, IL-1beta, or leukemia inhibitory factor exhibit nuclear hypertrophy comparable to that observed in vivo. Using a coculture bioassay, we further demonstrate that CNTF treatment of astrocytes increases their ability to support ChAT(+) ventral spinal cord neurons (presumably motor neurons) more than twofold compared with untreated astrocytes. Also, the complexity of neurites was significantly increased in neurons cultured with CNTF-treated astrocytes compared with untreated astrocytes. RT-PCR analysis demonstrated that CNTF increased levels of FGF-2 and nerve growth factor (NGF) mRNA and that IL-1beta increased NGF and hepatocyte growth factor mRNA levels. Furthermore, both CNTF and IL-1beta stimulated the release of FGF-2 from cultured spinal cord astrocytes. These findings demonstrate that cytokine-activated astrocytes better support CNS neuron survival via the production of neurotrophic molecules. We also show that CNTF synergizes with FGF-2, but not epidermal growth factor, to promote DNA synthesis in spinal cord astrocyte cultures. The significance of these findings is discussed by presenting a new model depicting the sequential activation of astrocytes by cytokines and growth factors in the context of CNS injury and repair.