Miracle-dz/UniFAR-FTUs huggingface dataset:
THE EFFECT OF LACK OF PENETRATION DEFECTS ON STATIC TENSILE BEHAVIOR OF HIGH-STRENGTH STRUCTURAL STEEL WELDMENTS

This paper investigates the effect of lack of penetration (LOP) in welded T-1 steel plates on tensile properties. Tensile tests of welded plates having varying sizes of LOP were conducted and monitored for acoustic emissions. Fracture surfaces were examined. Using a documented computer program the J integral of fracture mechanics was evaluated at several points for each specimen. An anticipated decrease in tensile strength and ductility with increasing LOP was observed. The fracture surface was found to pass in and out of the weld metal, the extent depending on LOP. The J integral analysis showed that welded T-1 steel joints with LOP are well approximated by the rigid-plastic model. This permits a critical value of the J integral to be computed from the load and deflection at peak load. There appears to be a critical LOP value below which the J integral is not valid. Moreover, the fracture occurs in the base metal for LOP less than one critical value, and in the weld metal for LOP greater than a second critical value higher than the first. For intermediate LOP values, failure occurs in the weld metal, but gross elongation occurs in the base metal. By using base metal yield and tensile strength, a net section criterion and a limit load stress, four modes of fracture behavior can be identified. These modes indicate three ranges of influence of LOP size on fracture. For LOP size less than a lower critical value, base metal dominates fracture. For LOP size greater than a larger critical value, LOP size controls fracture. For intermediate LOP size, the LOP dominates but does not fully control fracture.
Transmission and Reflection Coefficients for Damage Identification in 1D Elements

According to the latest research results presented in the literature changes in propagating waves are one of the most promising parameters for damage identification algorithms. Numerous publications describe methods of damage identification based on the analysis of signals reflected from damage. They also include complicated signal processing techniques. Such methods work well for damage localisation, but it is rather difficult to use them in order to estimate the size of damage. It is natural that propagating wave reflects from any structural discontinuity. The bigger the disturbance the bigger part of a propagating wave reflects from it. The amount of energy reflected and transmitted through any discontinuity can expressed as reflection and transmission coefficients. In the literature different application for these coefficients may be found – the most often cited application is connected with localising changes in the geometry of structures. Changes in the coefficients due to cross section variations in rods and beams or due to existence of stiffeners in plates are well documented. However there are no application of using the reflection and transmission coefficients for damage size identification. For this reason the analysis presented in this paper has been carried out. The article presents a method of damage identification in 1D elements based on the wave propagation phenomenon and changes in reflection and transmission coefficients. The changes in transmission and reflection coefficients for waves propagating in isotropic rods with different types of damage have been analysed. The rods have been modelled with the elementary, two and three mode theories or rods. For numerical modelling the Spectral Finite Element Method has been used. Several examples are given in the paper.
Weekly Versus Triweekly Cisplatin-Based Chemotherapy Concurrent With Radiotherapy in the Treatment of Cervical Cancer: A Meta-Analysis

Background The aim of this study was to evaluate toxicity, compliance, recurrence and the survival of weekly and triweekly cisplatin-based concomitant chemoradiation in treatment of cervical cancer. Materials and Methods The databases were searched from 1995 until 2015 to identify eligible studies on weekly versus triweekly cisplatin chemoradiotherapy. The data were analyzed by RevMan 5.3 software. Results A total of 5 randomized controlled trials were included in this review. Weekly cisplatin regimen significantly reduced the incidence of Hematologic toxicity. However, there was no significantly different between the 2 arms in compliance, recurrence and the survival rate (all P >0.05). Conclusions Weekly cisplatin regimen had the similar therapeutic effect as the triweekly cisplatin regimen but with less hematologic toxicity. Therefore, we recommend the weekly cisplatin 30 to 40 mg/m2 chemoradiotherapy as the strong candidate for the optimal cisplatin dose and dosing schedule in the treatment of locally advanced cervical cancer.
The cytoplasmic domain of the Plasmodium falciparum ligand EBA-175 is essential for invasion but not protein trafficking

The invasion of host cells by the malaria parasite Plasmodium falciparum requires specific protein–protein interactions between parasite and host receptors and an intracellular translocation machinery to power the process. The transmembrane erythrocyte binding protein-175 (EBA-175) and thrombospondin-related anonymous protein (TRAP) play central roles in this process. EBA-175 binds to glycophorin A on human erythrocytes during the invasion process, linking the parasite to the surface of the host cell. In this report, we show that the cytoplasmic domain of EBA-175 encodes crucial information for its role in merozoite invasion, and that trafficking of this protein is independent of this domain. Further, we show that the cytoplasmic domain of TRAP, a protein that is not expressed in merozoites but is essential for invasion of liver cells by the sporozoite stage, can substitute for the cytoplasmic domain of EBA-175. These results show that the parasite uses the same components of its cellular machinery for invasion regardless of the host cell type and invasive form.
Detecting p53 Immunoexpression inEsophageal Mucosa with Exfoliative Cytologyin Individuals at Risk for Squamous CellCarcinoma of the Esophagus

OBJECTIVE To determine the prevalence of p53 expression in cytologic smear collected by the RS Balloon in high-risk individuals, and test its yield in the cytologic screening of squamous cell carcinoma of the esophagus (SCCE). STUDY DESIGN Asymptomatic individuals at risk for SCCE underwent esophageal exfoliative cytology with the RS Balloon immediately followed by upper gastrointestinal endoscopy with biopsies of unstained areas after iodine mucosal staining of the esophagus. For each patient, cytologic expression of p53 was compared with the worst endoscopic biopsy diagnosis and the histologic expression of p53. RESULTS One hundred seventy-one individuals were submitted to the study's protocol. There were 8 lost cases (4.7%) due to inadequate cytologic samples. The final sample consisted of 163 individuals where 150 were male (92%), mean age of 52.6 +/- 12.0 years old. There were 3 cases of dysplasia/SCCE. Immunohistochemical expression of p53 protein was positive in 38 patients (23.6%), with basal layer expression in 29 (76.3%), middle layer expression in 8 (21.1%) and superficial layer in 1 (2.6%). All patients with dysplasia/SCCE had positive immunohistochemical expression of p53 protein. Immunocytochemical expression of p53 protein in cytologic smear was negative in all cytology samples. CONCLUSION The negative results of immunocytochemical expression of p53 protein suggest that its use does not contribute to improving the performance of conventional cytology of the esophagus in the screening for SCCE and its precursor lesions.
Development and Validation of a Measure of Self-Critical Rumination

Self-criticism is a form of negative self-evaluation that has strong associations with many forms of psychopathology. Rumination is a maladaptive form of repetitive thinking that is associated with many psychological disorders. Although measures of several different types of rumination (e.g., general rumination, depressive rumination, anger rumination) have been developed, none focuses specifically on self-critical rumination. An initial pool of items addressing self-critical rumination was developed by adapting items from existing rumination measures and through a writing task administered to both student and clinical samples. Following an evaluation of content validity, 24 items were administered to a large sample of undergraduates along with measures of related constructs. The final 10-item version of the Self-Critical Rumination Scale showed excellent internal consistency, a clear single-factor structure, convergent relationships with related constructs, and incremental validity over other measures of self-criticism and rumination in predicting both general distress and features of borderline personality disorder.
Gastrointestinal ultrasound in inflammatory bowel disease: an underused resource with potential paradigm-changing application

Evolution of treatment targets in IBD has increased the need for objective monitoring of disease activity to guide therapeutic strategy. Although mucosal healing is the current target of therapy in IBD, endoscopy is invasive, expensive and unappealing to patients. GI ultrasound (GIUS) represents a non-invasive modality to assess disease activity in IBD. It is accurate, cost-effective and reproducible. GIUS can be performed at the point of care without specific patient preparation so as to facilitate clinical decision-making. As compared with ileocolonoscopy and other imaging modalities (CT and MRI), GIUS is accurate in diagnosing IBD, detecting complications of disease including fistulae, strictures and abscesses, monitoring disease activity and detecting postoperative disease recurrence. International groups increasingly recognise GIUS as a valuable tool with paradigm-changing application in the management of IBD; however, uptake outside parts of continental Europe has been slow and GIUS is underused in many countries. The aim of this review is to present a pragmatic guide to the positioning of GIUS in IBD clinical practice, providing evidence for use, algorithms for integration into practice, training pathways and a strategic implementation framework.
Models of emission line profiles and spectral energy distributions to characterize the multi-frequency properties of active galactic nuclei

The spectra of Active Galactic Nuclei (AGNs) are often characterized by a wealth of emission lines with different profiles and intensity ratios that led to a complicated classification. Their electro-magnetic radiation spans more than 10 orders of magnitude in frequency. In spite of the differences between various classes, the origin of their activity is attributed to a combination of emitting components, surrounding an accreting Super Massive Black Hole, in the so called Unified Model. Currently, the execution of sky surveys, with instruments operating at various frequencies, provides the possibility to detect and to investigate the properties of AGNs on very large statistical samples. Thanks to the spectroscopic surveys that allow investigation of many objects, we have the opportunity to place new constraints on the nature and evolution of AGNs. In this contribution we present the results obtained by working on multi-frequency data and we discuss their relations with the available optical spectra. We compare our findings with the AGN Unified Model predictions, and we present a revised technique to select AGNs of different types from other line emitting objects. We discuss the multi-frequency properties in terms of the innermost structures of the sources.
Identification of New Factors Modulating Adhesion Abilities of the Pioneer Commensal Bacterium Streptococcus salivarius

Biofilm formation is crucial for bacterial community development and host colonization by Streptococcus salivarius, a pioneer colonizer and commensal bacterium of the human gastrointestinal tract. This ability to form biofilms depends on bacterial adhesion to host surfaces, and on the intercellular aggregation contributing to biofilm cohesiveness. Many S. salivarius isolates auto-aggregate, an adhesion process mediated by cell surface proteins. To gain an insight into the genetic factors of S. salivarius that dictate host adhesion and biofilm formation, we developed a screening method, based on the differential sedimentation of bacteria in semi-liquid conditions according to their auto-aggregation capacity, which allowed us to identify twelve mutations affecting this auto-aggregation phenotype. Mutations targeted genes encoding (i) extracellular components, including the CshA surface-exposed protein, the extracellular BglB glucan-binding protein, the GtfE, GtfG and GtfH glycosyltransferases and enzymes responsible for synthesis of cell wall polysaccharides (CwpB, CwpK), (ii) proteins responsible for the extracellular localization of proteins, such as structural components of the accessory SecA2Y2 system (Asp1, Asp2, SecA2) and the SrtA sortase, and (iii) the LiaR transcriptional response regulator. These mutations also influenced biofilm architecture, revealing that similar cell-to-cell interactions govern assembly of auto-aggregates and biofilm formation. We found that BglB, CshA, GtfH and LiaR were specifically associated with bacterial auto-aggregation, whereas Asp1, Asp2, CwpB, CwpK, GtfE, GtfG, SecA2 and SrtA also contributed to adhesion to host cells and host-derived components, or to interactions with the human pathogen Fusobacterium nucleatum. Our study demonstrates that our screening method could also be used to identify genes implicated in the bacterial interactions of pathogens or probiotics, for which aggregation is either a virulence trait or an advantageous feature, respectively.
Serum Samples That Have Been Stored Long-Term (>10 Years) Can Be Used as a Suitable Data Source for Developing Cardiovascular Risk Prediction Models in Large Observational Rheumatoid Arthritis Cohorts

Objective. There is an unmet need for a specific cardiovascular risk (CV) algorithm for rheumatoid arthritis (RA) patients. Lipoprotein data are often not available in RA cohorts but could be obtained from frozen blood samples. The objective of this study was to estimate the storage effect on lipoproteins in long-term (>10 years) frozen serum samples. Methods. Data were used from an inception RA cohort. Multiple serum samples from 152 patients were analyzed for lipoproteins, being frozen for 1–26 years at −20°C. Storage effect on lipoproteins was estimated using longitudinal regression analyses and a lipid decay correction factor was developed. Clinical impact of the storage effect on lipoproteins was assessed by calculating the number of patients reclassified to another CV risk group according to the SCORE risk calculator after applying the decay correction factor. Results. There was a significant effect of storage time on total cholesterol (TC) (P < 0.001) and high density lipoprotein cholesterol (HDL-c) levels (P < 0.001), not LDL-c (P = 0.83). The lipid decay correction factor was 0.03 mmol/L and 0.024 mmol/L per additional year of storage for TC and HDL-c, respectively. The TC : HDL ratio decreased after correction for storage effect. After correction, only 5% of patients were reclassified to another CV risk group. Conclusion. A modest storage decay effect on lipoproteins was found that is unlikely to significantly affect CV risk stratification. Serum samples that have been stored long-term (>10 years) can be used to obtain valid lipid levels for developing CV risk prediction models in RA cohorts, even without applying a decay correction factor.
Early diagnosis of acute myocardial infarction in patients with pre-existing coronary artery disease using more sensitive cardiac troponin assays.

AIMS We sought to examine the diagnostic and prognostic utility of sensitive cardiac troponin (cTn) assays in patients with pre-existing coronary artery disease (CAD). METHODS AND RESULTS We conducted a multicentre study to examine the diagnostic accuracy of one high-sensitive and two sensitive cTn assays in 1098 consecutive patients presenting with symptoms suggestive of acute myocardial infarction (AMI), of whom 401 (37%) had pre-existing CAD. Measurements of Roche high-sensitive cTnT (hs-cTnT), Siemens cTnI-Ultra, Abbott-Architect cTnI and the standard assay (Roche cTnT) were performed in a blinded fashion. The final diagnosis was adjudicated by two independent cardiologists. Acute myocardial infarction was the final diagnosis in 19% of CAD patients. Among patients with diagnoses other than AMI, baseline cTn levels were elevated above the 99th percentile with Roche hs-cTnT in 40%, with Siemens TnI-Ultra in 15%, and Abbott-Architect cTnI in 13% of them. In patients with pre-existing CAD, the diagnostic accuracy at presentation, quantified by the area under the receiver operator characteristic curve (AUC), was significantly greater for the sensitive cTn assays compared with the standard assay (AUC for Roche hs-cTnT, 0.92; Siemens cTnI-Ultra, 0.94; and Abbott-Architect cTnI, 0.93 vs. AUC for the standard assay, 0.87; P < 0.01 for all comparisons). Elevated levels of cTn measured with the sensitive assays predicted mortality irrespective of pre-existing CAD, age, sex, and cardiovascular risk factors. CONCLUSION Sensitive cTn assays have high-diagnostic accuracy also in CAD patients. Mild elevations are common in non-AMI patients and test-specific optimal cut-off levels tend to be higher in CAD patients than in patients without history of CAD. Sensitive cTn assays also retain prognostic value. (ClinicalTrials.gov number, NCT00470587).
NODDI reproducibility and variability with magnetic field strength: A comparison between 1.5 T and 3 T

Diffusion models are advantageous for examining brain microstructure non‐invasively and their validation is important for transference into the clinical domain. Neurite Orientation Dispersion and Density Imaging (NODDI) is a promising model for estimating multiple diffusion compartments from MRI data acquired in a clinically feasible time. As a relatively new model, it is necessary to examine NODDI under certain experimental conditions, such as change in magnetic field‐strength, and assess it in relation to diffusion tensor imaging (DTI), an established model that is largely understood by the neuroimaging community. NODDI measures (intracellular volume fraction, νic, and orientation distribution, OD) were compared with DTI at 1.5 and 3 T data in healthy adults in whole‐brain tissue masks and regions of white‐ and deep grey‐matter. Within‐session reproducibility and between‐subject differences of NODDI with field‐strength were also investigated. Field‐strength had a significant effect on NODDI measures, suggesting careful interpretation of results from data acquired at 1.5 and 3 T. It was demonstrated that NODDI is feasible at 1.5 T, but with lower νic in white‐matter regions compared with 3 T. Furthermore, the advantages of NODDI over DTI in a region of complex microstructure were shown. Specifically, in the centrum‐semiovale where FA is typically as low as in grey‐matter, νic was comparable to other white‐matter regions yet accompanied by an OD similar to deep grey‐matter. In terms of reproducibility, NODDI measures varied more than DTI. It may be that NODDI is more susceptible to noisier parameter estimates when compared with DTI, conversely it may have greater sensitivity to true within‐ and between‐subject heterogeneity. Hum Brain Mapp 37:4550–4565, 2016. © 2016 Wiley Periodicals, Inc.
Active Galactic Nuclei Search

We present the first results of medium-band photometric observations on the 1m Schmidt Telescope of Byurakan Astrophysical Observatory (Armenia). The object sample was created in the SA68 field. The medium-band filter set (13 filters with FWHM = 250 A + 5 broadband SDSS filters) allowed us to create low-resolution spectra of each object in the SA68 field. We compared them with the template spectra to select AGNs and to determine their photometric redshifts. Our sample consists of 330 objects with 0.5–5.1 redshift range and complete up to 23.0 AB magnitude. The comparison of our sample with SDSS DR10 and BOSS + MMT QSO showed that sufficiently more objects in the 3.2–5.1 redshift range were found.
Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos

Type I neurofibromatosis (NF1) is caused by mutations in the NF1 gene encoding neurofibromin. Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is thought to mediate cellular functions relevant to disease phenotypes. Loss of murine Nf1 results in embryonic lethality due to heart defects, while mice with monoallelic loss of function mutations or with tissue-specific inactivation have been used to model NF1. Here, we characterize previously unappreciated phenotypes in Nf1-/- embryos, which are inhibition of hemogenic endothelial specification in the dorsal aorta, enhanced yolk sac hematopoiesis, and exuberant cardiac blood island formation. We show that a missense mutation engineered into the active site of the Ras-GAP domain is sufficient to reproduce ectopic blood island formation, cardiac defects, and overgrowth of neural crest-derived structures seen in Nf1-/-embryos. These findings demonstrate a role for Ras-GAP activity in suppressing the hemogenic potential of the heart and restricting growth of neural crest-derived tissues. DOI: http://dx.doi. org/10.7554/eLife.07780. 001
A Nogo-Like Signaling Perspective from Birth to Adulthood and in Old Age: Brain Expression Patterns of Ligands, Receptors and Modulators

An appropriate strength of Nogo-like signaling is important to maintain synaptic homeostasis in the CNS. Disturbances have been associated with schizophrenia, MS and other diseases. Blocking Nogo-like signaling may improve recovery after spinal cord injury, stroke and traumatic brain injury. To understand the interacting roles of an increasing number of ligands, receptors and modulators engaged in Nogo-like signaling, the transcriptional activity of these genes in the same brain areas from birth to old age in the normal brain is needed. Thus, we have quantitatively mapped the innate expression of 11 important genes engaged in Nogo-like signaling. Using in situ hybridization, we located and measured the amount of mRNA encoding Nogo-A, OMgp, NgR1, NgR2, NgR3, Lingo-1, Troy, Olfactomedin, LgI1, ADAM22, and MAG, in 18 different brain areas at six different ages (P0, 1, 2, 4, 14, and 104 weeks). We show gene- and area-specific activities and how the genes undergo dynamic regulation during postnatal development and become stable during adulthood. Hippocampal areas underwent the largest changes over time. We only found differences between individual cortical areas in Troy and MAG. Subcortical areas presented the largest inter-regional differences; lateral and basolateral amygdala had markedly higher expression than other subcortical areas. The widespread differences and unique expression patterns of the different genes involved in Nogo-like signaling suggest that the functional complexes could look vastly different in different areas.
Protocol-Aware Recovery for Consensus-Based Storage

We introduce protocol-aware recovery (PAR), a new approach that exploits protocol-specific knowledge to correctly recover from storage faults in distributed systems. We demonstrate the efficacy of PAR through the design and implementation of corruption-tolerant replication (CTRL), a PAR mechanism specific to replicated state machine (RSM) systems. We experimentally show that the CTRL versions of two systems, LogCabin and ZooKeeper, safely recover from storage faults and provide high availability, while the unmodified versions can lose data or become unavailable. We also show that the CTRL versions have little performance overhead.