Miracle-dz/UniFAR-FTUs huggingface dataset:
Building IT Capability to Increase Organizational Performance: A Path-Oriented Process

Most studies on information technology (IT) capability have drawn their conceptualization from the tenets of resource-based view (RBV). Though path dependence is central to the concept of RBV, very few studies have examined the developmental paths of IT capabilities, which are typically treated as first-order constructs with their effects on firm performance investigated as direct causal links. This paper conceptualizes IT capability as the outcome of a path- specific resource building process, driven by the e-business skills and knowledge of a firm’s IT human resources, which we refer to as e-business centric IT expertise. We posit that through the use of appropriate IT infrastructure, and the development of back-end integration and front-end functionalities, e-business centric IT expertise could be harnessed to provide the right information to the right customers at the right time, giving rise to a firm-specific IT capability. We further contend that IT capability is a source of competitive advantage, offering inimitable differentiation in market responsive agility, which is a key to securing sales in an increasingly customer-centric market. We operationalize these conceptualizations as a structural equation model (SEM) and tested 12 hypothesized relationships using data drawn from a survey of 310 fast-growth smallto-medium sized companies in Australia. The test results uphold 10 of the 12 formulated hypotheses, supporting our conceptualization that IT capability building is a path-specific process. To affirm our contention that IT capability is developed from the interacting effects of a suite of IT resources, and not the sum of the disjointed effects of individual resources, we also formulated and tested an alternative model that links individual IT resources directly to market responsive agility. Combined with a series of mediation tests, our SEM exercises confirm that IT resources interact in a specific way to give rise to IT capability to enhance market responsive agility and achieve sales performance. We discuss the implications of these findings in the context of IT investment.
Development of hypertension over 6 years in a birth cohort of young middle‐aged men: the Cardiovascular Risk Factor Study in southern Sweden (CRISS)

Abstract. Henriksson KM, Lindblad U, Gullberg B, Ågren B, Nilsson‐Ehle P, Råstam L (Lund University, Skaraborg Institute and Helsingborg County Hospital, Sweden). Development of hypertension over 6 years in a birth cohort of young middle‐aged men: the Cardiovascular Risk Factor Study in southern Sweden (CRISS). J Intern Med 2002; 252: 21–26.
Explorer Bounded Query Rewriting Using Views

A query Q has a bounded rewriting using a set of views if there exists a query Q expressed in the same language as Q, such that given a dataset D, Q(D) can be computed by Q that accesses only cached views and a small fraction DQ of D. We consider datasets D that satisfy a set of access constraints, a combination of cardinality constraints and associated indices, such that the size |DQ| of DQ and the time to identify DQ are independent of |D|, no matter how big D is. This paper studies the problem for deciding whether a query has a bounded rewriting given a set V of views and a set A of access constraints. We establish the complexity of the problem for various query languages, from Σp3-complete for conjunctive queries (CQ), to undecidable for relational algebra (FO). We show that the intractability for CQ is rather robust even for acyclic CQ with fixed V and A, and characterize when the problem is in PTIME. To make practical use of bounded rewriting, we provide an effective syntax for FO queries that have a bounded rewriting. The syntax characterizes a core subclass of such queries without sacrificing the expressive power, and can be checked in PTIME.
Sequence of a cDNA coding for human IRF-2.

Nucleic Acids Research Sequence of a cDNA coding for human IRF-2 Susumu Itoh*, Hisashi Harada, Takashi Fujita, Tsutomu Mimura and Tadatsugu Taniguchi Institute for Molecular and Cellular Biology, Osaka University, Yamadaoka 1-3, Suita-Shi, Osaka 565 and 'Faculty of Pharmaceutical Science, Osaka University, Yamadaoka 1-6, Suita-shi, Osaka 565, Japan Submitted September II, 1989 EMBL accession no. XI5949 We have previously isolated a cDNA done, a mouse interferon regulatory factor-2 (IRF-2) (Harada, H , Fujita, T., Miyamoto, ivL, Kimura, Y., Maruyama, M, Furia, A., Miyata, T. and Taniguchi, T., 1989, Cell, 5J, 729-739). We have isolated a human IRF-2 cDNA coding for human IRF-2 by crosshybridization with the mouse IRF-2 full length cDNA probe, using the human T cell line, Jurkat-111 cDNA library. One of the positive clones, pfflRF4S-51, was sequenced. This cDNA includes 98 bp of 5"untranslated, 1047 bp of coding and 999 bp of 3'-untranslated regions. The deduced amino acid sequence is the 349 amino acid protein and this protein shows 93.5% homology, compared with mouse IRF-2. Furthermore, the amino terminal hah' of human IRF-2 from 1 to 113 amino acid has 73% homology to human IRF-1 (Maruyama, M., Fujita, T. and Taniguchi, T., Nucleic Acidi Research, 1989, 7,3292).
Fine Mapping of an Epitope Recognized by an Invasion-inhibitory Monoclonal Antibody on the Malaria Vaccine Candidate Apical Membrane Antigen 1*

Antibodies that inhibit red blood cell invasion by the Plasmodium merozoite block the erythrocytic cycle responsible for clinical malaria. The invasion-inhibitory monoclonal antibody (mAb) 4G2 recognizes a conserved epitope in the ectodomain of the essential Plasmodium falciparum microneme protein and vaccine candidate, apical membrane antigen 1 (PfAMA1). Here we demonstrate that purified Fab fragments of 4G2 inhibit invasion markedly more efficiently than the intact mAb, suggesting that the invasion-inhibitory activity of this mAb is not due solely to steric effects and that the epitope lies within a functionally critical region of the molecule. We have taken advantage of a synthetic gene encoding a modified form of PfAMA1, and existing x-ray crystal structure data, to fully characterize this epitope. We first validate the gene by demonstrating that it fully complements the function of the authentic gene in P. falciparum.We then use it to identify a group of residues within the previously described domain II loop of PfAMA1 that are critical for recognition by mAb 4G2 and demonstrate that the epitope lies exclusively within this loop with no contributions from residues in other domains of the molecule. This is the first complete characterization of a conserved invasion-inhibitory epitope on PfAMA1. Our results will aid in the design of subunit vaccines designed to generate a broadly effective, focused anti-PfAMA1 protective immune response and may help elucidate the function of PfAMA1.
VALUE CHAIN ANALYSIS OF BROILER TO INCREASE COMPETITIVENESS (CASE STUDY AT PT. CHAROEN POKPHAND INDONESIA, TBK)

The objectives of this research are to (1) map the value chain in broiler at PT. Charoen Pokphand Indonesia, Tbk (CPI); (2) analyze the value chain governance in broiler at CPI; (3) analyze the margin of marketing at broiler industry both on farm or off farm; (3) analyze the gap between the expectation and the performance of consumers (farmers) upon using products of CPI and (4) recognize factors influencing competitiveness in broiler industry; and (5) to formulate strategy for value chain upgrading at CPI in order to increase competitiveness of broiler. As revealed by the value chain analysis, the role of CPI in this value chain is highly significant. All poultry inputs (DOC, feed, veterinary medicine, and poultry equipments) are supplied by CPI. As for downstream sector, CPI processes broiler into its derivatives. The type of value chain governance between feed supplier, DOC, and veterinary medicine, poultry equipment, and poultry derivates belongs to market value chain. Whereas the type of value chain governance between carcass supplier and restaurant belongs to captive value chain. Based on the margin of marketing analysis, the party that gains the lowest margin is farmer and the party that receives the highest margin is the processor. In gap analysis, the lowest attribute of competitiveness is the feed spending and the highest attribute is the spending on veterinary medicine for two months. Factors that influence the competitiveness in poultry industry are condition, demand, industry competition, main industries and supporting industries, and government’s role.Keywords: Value Chain, Competitiveness, Broiler, PT. Charoen Pokphand Indonesia, Tbk, Margin of Marketing Analysis, Gap Analysis, SWOT Analysis
Autoimmune Aspects of Pemphigus Vulgaris and Mucosal Pemphigoid

Oral mucosal lesions of ulcerative, desquamative, and bullous character are major problems for clinicians and patients alike. Underlying such processes is the autoimmune reaction manifesting as specific subsets of immunopathology. Responsible for the maintenance of mucosal integrity within the oral cavity are numerous adhesion proteins which operate at the cell-to-cell and cell-to-connective-tissue-matrix level. Two of the better-understood conditions characterized by altered or disordered levels of adherence are the pemphigus and the pemphigoid groups of lesions. Autoantibodies in pemphigus vulgaris specifically attack normal proteins within the desmosomal structure. Cellular adhesion is affected by steric interference by antibodies directed against antigens residing within the intercellular space or the desmosome itself. Such alterations ultimately result in cell-to-cell separation, with production of the acantholytic element characteristic of pemphigus vulgaris. Mucous membrane pemphigoid is characterized by a separation at the junction of the epithelium and connective tissue at the level of the basement membrane complex. Histologically, a split occurs in the sub-basilar region, with antibodies directed to the 230-kDa protein component of the hemidesmosome. Minor antigens residing within the basement membrane area include a 180-kDa element as well as other less commonly found proteins near the membrane complex. Manifestations of these illnesses are often severe. Management strategies of pemphigus vulgaris have changed over the recent past, with new modalities supplementing the traditional corticosteroid approach. Both conditions are usually lifelong, with the implications of management a major consideration.
Lithium Dendrite Inhibition on Post-Charge Anode Surface: The Kinetics Role

We report experiments and molecular dynamics calculations on the kinetics of electrodeposited lithium dendrites relaxation as a function of temperature and time. We found that the experimental average length of dendrite population decays via stretched exponential functions of time toward limiting values that depend inversely on temperature. The experimental activation energy derived from initial rates as E_a~ 6-7 kcal/mole, which is closely matched by MD calculations, based on the ReaxFF force field for metallic lithium. Simulations reveal that relaxation proceeds in several steps via increasingly larger activation barriers. Incomplete relaxation at lower temperatures is therefore interpreted a manifestation of cooperative atomic motions into discrete topologies that frustrate monotonic progress by ‘caging’.
Effect of a Toolkit and a One-Day Teacher Education Workshop on ESD Teaching Content and Methods—A Study from Kosovo

Environmental education in Kosovo is currently under reform. The new strategy for sustainable development demands a strong focus on education for sustainability in schools. However, a lack of teacher education might impede new approaches in the classroom. This study investigated how teachers in Kosovo approach locally-relevant environmental issues in the classroom before and after a one-day in-service workshop on teaching approaches related to education for sustainable development (ESD). Data were gathered in nine classes with a systematic observation scheme and processed using Flanders’ interaction analysis categories system. During the workshop, a specially designed toolkit was introduced to the participants (nine biology teachers from the upper secondary level). The toolkit included teaching approaches suitable for ESD and focused on air and water pollution, waste management, energy saving, and the conservation of biodiversity. Before the workshop, teacher-talk occupied more than 90% of a typical 45-min lesson, and instructions were frontal and directive. After the workshop, pupil-talk strongly increased (up to 88%), and pupils were actively engaged in activities suitable for ESD. Supportive training can thus help teachers to improve their instructional practices. However, only those teachers who had reported support from head teachers and colleagues were still frequently using the toolkit after one year.
Template Requirements for De Novo RNA Synthesis by Hepatitis C Virus Nonstructural Protein 5B Polymerase on the Viral X RNA

ABSTRACT The hepatitis C virus (HCV)-encoded NS5B protein is an RNA-dependent RNA polymerase which plays a substantial role in viral replication. We expressed and purified the recombinant NS5B of an HCV genotype 3a from Esherichia coli, and we investigated its ability to bind to the viral RNA and its enzymatic activity. The results presented here demonstrate that NS5B interacts strongly with the coding region of positive-strand RNA, although not in a sequence-specific manner. It was also determined that more than two molecules of polymerase bound sequentially to this region with the direction 3′ to 5′. Also, we attempted to determine the initiation site(s) of de novo synthesis by NS5B on X RNA, which contains the last 98 nucleotides of HCV positive-strand RNA. The initiation site(s) on X RNA was localized in the pyrimidine-rich region of stem I. However, when more than five of the nucleotides of stem I in X RNA were deleted from the 3′ end, RNA synthesis initiated at another site of the specific ribonucleotide. Our study also showed that the efficiency of RNA synthesis, which was directed by X RNA, was maximized by the GC base pair at the penultimate position from the 3′ end of the stem. These results will provide some clues to understanding the mechanism of HCV genomic RNA replication in terms of viral RNA-NS5B interaction and the initiation of de novo RNA synthesis.
Simulation and Performance Evaluation of Different Propagation model under Urban, Suburban and Rural Environments for mobile communication

Nowadays the Global System for Mobile Communication (originally from Groupe Special Mobile) –GSM technology becomes popular. GSM has potential success in its line-of-sight (LOS) and non line-of-sight (NLOS) conditions which operating in the 900 MHz or 1800/1900 MHz bands. There are going to be a surge all over the world for the deployment of GSM networks. Estimation of path loss is very important in initial deployment of wireless network and cell planning. Numerous path loss (PL) models (e.g. Okumura Model, Hata Model) are available to predict the propagation loss. If Path loss increases, then signal power decrease and also bit error rate increase. This paper compares and analyzes three path loss models namely COST 231 Hata model, Ericsson model and COST 231 Walfish-Ikegami model. AWGN channel is used for all simulations. These models are simulated with different frequencies, distance between transmitter and receiver, transmitter antenna and receiver antenna heights in urban, suburban and rural environments in Non Line of site (NLOS) condition. Our main concentration in this paper is to find out a suitable model for different environments to provide guidelines for cell planning of GSM Network.
A Grid of NLTE Line-blanketed Model Atmospheres of Early B-Type Stars

We have constructed a comprehensive grid of 1540 metal line-blanketed, NLTE, plane-parallel, hydrostatic model atmospheres for the basic parameters appropriate to early B-type stars. The BSTAR2006 grid considers 16 values of effective temperatures, 15,000 K ≤ Teff ≤ 30,000 K with 1000 K steps, 13 surface gravities, 1.75 ≤ log g ≤ 4.75 with 0.25 dex steps, six chemical compositions, and a microturbulent velocity of 2 km s-1. The lower limit of log g for a given effective temperature is set by an approximate location of the Eddington limit. The selected chemical compositions range from twice to one-tenth of the solar metallicity and metal-free. Additional model atmospheres for B supergiants (log g ≤ 3.0) have been calculated with a higher microturbulent velocity (10 km s-1) and a surface composition that is enriched in helium and nitrogen and depleted in carbon. This new grid complements our earlier OSTAR2002 grid of O-type stars (our Paper I). The paper contains a description of the BSTAR2006 grid and some illustrative examples and comparisons. NLTE ionization fractions, bolometric corrections, radiative accelerations, and effective gravities are obtained over the parameter range covered by the grid. By extrapolating radiative accelerations, we have determined an improved estimate of the Eddington limit in absence of rotation between 55,000 and 15,000 K. The complete BSTAR2006 grid is available at the TLUSTY Web site.
Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus

TGFβ activation and signaling have been extensively studied in experimental models of allergen-induced asthma as potential therapeutic targets during chronic or acute phases of the disease. Outcomes of experimental manipulation of TGFβ activity have been variable, in part due to use of different model systems. Using an ovalbumin (OVA)-induced mouse model of asthma, we here show that innate variation within TGFβ1 genetic modifier loci, Tgfbm2 and Tgfbm3, alters disease susceptibility. Specifically, Tgfbm2129 and Tgfbm3C57 synergize to reverse accentuated airway hyperresponsiveness (AHR) caused by low TGFβ1 levels in Tgfb1+/− mice of the NIH/OlaHsd strain. Moreover, epistatic interaction between Tgfbm2129 and Tgfbm3C57 uncouples the inflammatory response to ovalbumin from those of airway remodeling and airway hyperresponsiveness, illustrating independent genetic control of these responses. We conclude that differential inheritance of genetic variants of Tgfbm genes alters biological responses to reduced TGFβ1 signaling in an experimental asthma model. TGFβ antagonists for treatment of lung diseases might therefore give diverse outcomes, dependent on genetic variation.
Pixel-based correction for Charge Transfer Inefficiency in the Hubble Space Telescope Advanced Camera for Surveys

Charge Transfer Inefficiency (CTI) due to radiation damage above the Earth's atmosphere creates spurious trailing in Hubble Space Telescope (HST) images. Radiation damage also creates unrelated warm pixels – but these happen to be perfect for measuring CTI. We model CTI in the Advanced Camera for Surveys (ACS)/Wide Field Channel and construct a physically motivated correction scheme. This operates on raw data, rather than secondary science products, by returning individual electrons to pixels from which they were unintentionally dragged during readout. We apply our correction to images from the HST Cosmic Evolution Survey (COSMOS), successfully reducing the CTI trails by a factor of ~30 everywhere in the CCD and at all flux levels. We quantify changes in galaxy photometry, astrometry and shape. The remarkable 97 per cent level of correction is more than sufficient to enable a (forthcoming) reanalysis of downstream science products and the collection of larger surveys.
Optimal estimation retrievals of the atmospheric structure and composition of HD 189733b from secondary eclipse spectroscopy

Recent spectroscopic observations of transiting hot Jupit ers have permitted the derivation of the thermal structure and molecular abundances of H2O, CO2, CO, and CH4 in these extreme atmospheres. Here, for the first time, we apply the tech nique of optimal estimation to determine the thermal structure and composition of an exoplanet by solving the inverse problem. The development of a suite of radiative transfer and retrieval tools for exoplanet atmospheres is described, building upon a retrieval algori thm which is extensively used in the study of our own solar system. First, we discuss the plausibility of detection of different molecules in the dayside atmosphere of HD 189733b and the best-fitting spectrum retrieved from all publicly available sets of secondary eclipse obser vations between 1.45 and 24 µm. Additionally, we use contribution functions to assess the vertical sensitivity of the emission spectrum to temperatures and molecular composition. Over the altitudes probed by the contribution functions, the retrieved thermal structure show s an isothermal upper atmosphere overlying a deeper adiabatic layer (temperature decreasing with altitude), which is consistent with previously-reported dynamical and observational results. The formal uncertainties on retrieved parameters are estimated conservatively using an analysis of the cross-correlation functions and the degeneracy between different atmospheric properties. The formal solution of the inverse problem suggests that the uncertainties on retr ieved parameters are larger than suggested in previous studies, and that the presence of CO and CH4 is only marginally supported by the available data. Nevertheless, by including as broad a wavelength range as possible in the retrieval, we demonstrate that available spectra of HD 189733b can constrain a family of potential solutions for the atmospheric structure.
Rivermead Mobility Index: a brief review of research to date

Objective: To determine the extent of use of the Rivermead Mobility Index (RMI) in published research and document findings relevant to the RMI in that research. Design: Literature search and document analysis. Results: Eight research articles in which the RMI was used were found. The RMI was described as reliable, correlated with other published scales, and responsive to changes over time. Conclusions: The RMI possesses characteristics desirable in a measurement scale. It warrants broader application.
An attempt at objective and subjective evaluation of the therapeutic efficacy of focused and radial shockwave applied to symptomatic heel spur.

PURPOSE The experiment was designed to evaluate and compare the efficacy of focused shockwave and radial shockwave in symptomatic heel spur treatment. Postural balance tests were used to ensure the objectivity of evaluations. METHODS Forty three patients with symptomatic heel spur were divided into two comparative groups that received respectively focused shockwave therapy (the FSWT group; 2000 impulses, 4 Hz, 0.4 mJ/mm2) and radial shockwave therapy (the RSWT group; 2000 impulses, 8 Hz, 5 bars + 2000 impulses, 8 Hz, 2.5 bars). Each patient received 5 treatments at weekly intervals. Before therapy started and 1, 3, 6 and 12 weeks after it ended, the intensity of pain experienced by the patients was assessed and static balance tests were performed on a force platform. RESULTS Successive measurements showed that the intensity of all kinds of pain under consideration was decreasing gradually and statistically significantly in both groups. The percentage reduction in pain intensity was similar between the groups. The standard deviation of the COP in the anterior-posterior and medial-lateral directions, 95% confidence ellipse area and COP velocity kept varying throughout the experiment, but in none of the groups changes were statistically significant. CONCLUSIONS Focused shockwave therapy and radial shockwave therapy improve the well-being of patients with symptomatic heel spur significantly and comparably. Posturography cannot deliver unambiguous data for tracking changes that the two therapies induce in these patients.