Miracle-dz/UniFAR-FTUs huggingface dataset:
Conference on Modelling of Machining Operations The CEL method as an alternative to the current modelling approaches for Ti 6 Al 4 V orthogonal cutting simulation

The finite element approach is often adopted to study the machining process. The Lagrangian and Eulerian formulations or even Arbitrary Eulerian-Lagrangian (ALE), one of their combinations, are the most employed in the current literature; each having their pros and cons. One of the most challenging issue in finite element modelling is the large strains during the cutting process that induce high deformation levels in the elements of the mesh. Remeshing contributes to decreasing mesh deformation but the criterion adopted to control it influences the results. The Coupled Eulerian-Lagrangian (CEL) method proposes to combine the Lagrangian and Eulerian formalisms without any element deformation problem. This paper studies its implementation in Ti6Al4V orthogonal cutting. The results are then compared to an experimental reference, as well as more standard models: an ALE model developed with Abaqus, an implicit Lagrangian model developed with Deform and an explicit Lagrangian model developed with AdvantEdge. The comparison is mainly based on the cutting forces and the chip morphology. It shows that the CEL formulation is a competitive alternative to the more standard models. © 2017 The Authors. Published by Elsevier B.V. Peer-review under responsibility of the scientific committee of The 16th CIRP Conference on Modelling of Machining Operations, in the person of the Conference Chairs Prof. J.C. Outeiro and Prof. G. Poulachon.
Signal transducer and activator of transcription 1 (Stat1) maintains basal mRNA expression of pro‐survival stat3‐target genes in glioma C6 cells

The STAT proteins (signal transducers and activators of transcription) are transcription factors mediating cytokine/growth factor signaling, which play important role in controlling cell cycle progression and apoptosis. In many cancer cell lines and tumors (including gliomas) the STAT proteins (in particular Stats 1, 3, and 5) are persistently activated. In this study, we employed DNA decoys, siRNAs, and protein overexpression, to elucidate the role of Stat1 and Stat3 in regulation of expression of endogenous Stat3‐target genes (Bcl2l1, Myc, Ccnd1) and a Stat‐driven reporter plasmid, in rat C6 glioma cells. The results obtained with the decoys and siRNA suggest that in proliferating C6 cells, Stat1 supports the basal expression of Bcl2l1, while the decoy and chromatin immunoprecipitation results suggest it also plays a similar role for Myc. In the Stat‐driven reporter system, overexpression of Stat1 stimulated, while overexpression of Stat3 inhibited the reporter gene expression. The level of Stat1 phosphorylation observed under basal conditions in proliferating glioma C6 cells is very low. Therefore, we speculate that it is the activity of the unphosphorylated Stat1 that is inhibited by Stat1 decoy or Stat1 siRNA. Taken together, our results demonstrate that it is Stat1 not Stat3 that maintains the expression of Bcl2l1 and possibly Myc in proliferating glioma C6 cells. An established paradigm is that Stat3 exerts a pro‐survival and potentially oncogenic effects, while Stat1 is mainly associated with the immune response. Our results add to a number of reports that challenge this paradigm. J. Cell. Biochem. 112: 3685–3694, 2011. © 2011 Wiley Periodicals, Inc.
Expressive speech analysis for epoch extraction using zero frequency filtering approach

The present work discusses the issues of epoch extraction from expressive speech signals. Epochs represent the accurate glottal closure instants in voiced speech which in turn give the accurate instants of maximum excitation of the vocal tract. Even though, there are many existing methods for epoch extraction, which provide near perfect epoch estimation from clean or neutral speech, these methods show significant drop in the epoch extraction performance for expressive speech signals. The occurrence of uncontrolled and rapid pitch variations in expressive speech signals cause degradation in the epoch extraction performance. The objective of the present work is to improve the epoch extraction performance of the speech signals with various perceptually distinct expressions compared to neutral speech using zero frequency filtering (ZFF) approach. In order to capture the rapid and uncontrolled variations in expressive speech utterances, trend removal is performed on short segments (25 ms) of the output obtained from the cascade of three zero frequency resonators (ZFR). The epoch estimation performance of the proposed method is compared with the conventional ZFF method, existing refined ZFF method proposed for expressive speech and recently proposed zero band filtering (ZBF) approach. The effectiveness of the approach is confirmed by the improved epoch identification rate and reduced miss and false alarm rates compared with that of the existing methods.
Safety and immunogenicity of Onderstepoort Biological Products’ Rift Valley fever Clone 13 vaccine in sheep and goats under field conditions in Senegal

Abstract This blinded field safety study was conducted in Senegal to assess safety and immunogenicity of administration of the registered dose of Rift Valley fever virus (RVFV) Clone 13 vaccine (Onderstepoort Biological Products) to sheep and goats of West African breeds under natural conditions. A total of 267 small ruminants (220 sheep, 47 goats) were included; half received RVFV Clone 13 vaccine at the recommended dose and half received the diluent (as placebo) only. The study was performed on three commercial farms in the northern and eastern region of Senegal in accordance with veterinary good clinical practices. The animals were observed daily for 3 days after vaccination, and then weekly for 1 year. In both sheep and goats vaccinated against RVFV seroconversion rates above 70% were recorded. No seroconversion related to RVFV was observed in placebo-treated animals. No statistically significant differences were determined between placebo and vaccinated groups for mean rectal temperatures for the first 3 days after administration (p > 0.05). No abnormal clinical signs related to treatment were noted, and only one slight injection site reaction was observed in one vaccinated animal for 2 days after vaccination. Out of 176 births assessed over 1 year (93 from the vaccinated group, 83 from the placebo group), 9 were abnormal in the placebo group and 3 in the vaccinated group (p > 0.05). The frequency of adverse events was similar in the placebo and vaccinated groups. RVFV Clone 13 vaccine administered according to the manufacturer's instructions was safe and well tolerated in West African breeds of sheep and goats, including animals of approximately 6 months of age and pregnant females, under field conditions in Senegal. Antibody levels persisted up to 1 year after vaccination.
Whispering gallery modes at 800 nm and 1550 nm in concentric Sinc / Er : SiO 2 microdisks

We examined a concentric Si nanocrystal (Si-nc) and Er doped SiO2 (Er:SiO2) microdisk structure supporting high-Q whispering gallery modes (WGMs) at both visible and telecom wavelengths. This structure provides a means to utilize Si-nc luminescence as an optical pump for an Er:SiO2 cavity without subjecting a telecom-wavelength, Er:SiO2-based mode to loss mechanisms associated with the Si-nc material. After fabricating a concentric microdisk consisting of an inner Si-nc disk and an outer Er:SiO2 ring, we characterize visible wavelength WGMs excited by the Si-nc photoluminescence and observed spectrometer limited quality factors as high as 10. Telecom-wavelength photoluminescence from the Er:SiO2 ring was measured to have a quality factor as high as 10 in the erbium luminescence region using a passive pulled fiber setup. Keyword: microresonator, nanocrystal, whispering gallery mode
Evolutionary processes driving spatial patterns of intraspecific genetic diversity in river ecosystems

Describing, understanding and predicting the spatial distribution of genetic diversity is a central issue in biological sciences. In river landscapes, it is generally predicted that neutral genetic diversity should increase downstream, but there have been few attempts to test and validate this assumption across taxonomic groups. Moreover, it is still unclear what are the evolutionary processes that may generate this apparent spatial pattern of diversity. Here, we quantitatively synthesized published results from diverse taxa living in river ecosystems, and we performed a meta‐analysis to show that a downstream increase in intraspecific genetic diversity (DIGD) actually constitutes a general spatial pattern of biodiversity that is repeatable across taxa. We further demonstrated that DIGD was stronger for strictly waterborne dispersing than for overland dispersing species. However, for a restricted data set focusing on fishes, there was no evidence that DIGD was related to particular species traits. We then searched for general processes underlying DIGD by simulating genetic data in dendritic‐like river systems. Simulations revealed that the three processes we considered (downstream‐biased dispersal, increase in habitat availability downstream and upstream‐directed colonization) might generate DIGD. Using random forest models, we identified from simulations a set of highly informative summary statistics allowing discriminating among the processes causing DIGD. Finally, combining these discriminant statistics and approximate Bayesian computations on a set of twelve empirical case studies, we hypothesized that DIGD were most likely due to the interaction of two of these three processes and that contrary to expectation, they were not solely caused by downstream‐biased dispersal.
Case management is associated with improved antiretroviral adherence and CD4+ cell counts in homeless and marginally housed individuals with HIV infection.

BACKGROUND Case management (CM) coordinates care for persons with complex health care needs. It is not known whether CM is effective at improving biological outcomes among homeless and marginally housed persons with human immunodeficiency virus (HIV) infection. Our goal was to determine whether CM is associated with reduced acute medical care use and improved biological outcomes in homeless and marginally housed persons with HIV infection. METHODS We conducted a prospective observational cohort study in a probability-based community sample of HIV-infected homeless and marginally housed adults in San Francisco, California. The primary independent variable was CM, defined as none or rare (any CM in <or=25% of quarters in the study), moderate (>25% but <or=75%), or consistent (>75%). The dependent variables were 3 self-reported health service use measures (receipt of primary care, emergency department visits and hospitalizations, and antiretroviral therapy adherence) and 2 biological measures (increase in CD4(+) cell count of >or=50% and geometric mean HIV load of <or=400 copies/mL). RESULTS In multivariate models, CM was not associated with increased primary care, emergency department use, or hospitalization. Moderate CM, compared with no or rare CM, was associated with an adjusted beta coefficient of 0.13 (95% confidence interval [CI], 0.02-0.25) for improved antiretroviral adherence. Consistent CM (adjusted odds ratio [AOR], 10.7; 95% CI, 2.3-49.6) and moderate CM (AOR, 6.5; 95% CI, 1.3-33.0) were both associated with >or=50% improvements in CD4(+) cell count. CM was not associated with geometric HIV load <400 copies/mL when antiretroviral therapy adherence was included in the model. Study limitations include a lack of randomization. CONCLUSION CM may be a successful method to improve adherence to antiretroviral therapy and biological outcomes among HIV-infected homeless and marginally housed adults.
Enhancement of Heat Transfer Using Fe 3 O 4 / Water Nanofluid with Varying Cut-Radius Twisted Tape Inserts

An attempt is made to enhance the rate of heat transfer in heat exchangers using Fe3O4 nanofluid. In this work an experimental analysis on twisted tape inserts with varying cutradius in Hair pin heat exchanger using Fe3O4 water based nanofluid is presented. Experimental data is generated at the mass flow rates of ranging from 0.05Kg/s to 0.25Kg/s and the Reynolds number ranging between 3000 to 25000.where as the flow rate of the hot fluid in the annulus is maintained constant (0.1Kg/s). The Heat transfer coefficient and corresponding friction factors required for performance analysis are determined for various particle volume concentrations of 0.01% and 0.03%. The Nusselt number of entire pipe for 0.03% concentrations of nanofluid with radius of cut, r=6 insert of H/D=3 is enhanced by 32.01% as compared water. The friction factor of entire pipe for 0.03% concentration of nanofluid with radius of cut, r=6 twisted tape insert of H/D=3 is enhanced by 1.21 times as compared to water. The results of the investigation shows an enhancement in the performance parameter of the heat exchanger namely heat transfer coefficient friction factor with an increase in volume concentration of the nanofluid.
Novel Functions of Stomatal Cytokinesis-Defective 1 (SCD1) in Innate Immune Responses against Bacteria*

Eukaryotes employ complex immune mechanisms for protection against microbial pathogens. Here, we identified SCD1 (Stomatal Cytokinesis-Defective 1), previously implicated in growth and development through its role in cytokinesis and polarized cell expansion (Falbel, T. G., Koch, L. M., Nadeau, J. A., Segui-Simarro, J. M., Sack, F. D., and Bednarek, S. Y. (2003) Development 130, 4011–4024) as a novel component of innate immunity. In Arabidopsis, SCD1 is a unique gene encoding for the only protein containing a complete DENN (Differentially Expressed in Normal and Neoplastic cells) domain. The DENN domain is a largely uncharacterized tripartite protein motif conserved among eukaryotic proteins. We show that conditional scd1-1 plants containing a point mutation in a conserved DENN residue affected a subset of signaling responses to some bacterial pathogen-associated molecular patterns (PAMPs). Consistent with increased transcript accumulation of Pathogen-related (PR) genes, scd1-1 plants were more resistant to Pseudomonas syringae pathovar tomato (Pst) DC3000 infection implicating SCD1 as a negative regulator of basal resistance against bacteria. scd1-1 plants were different from known mutants exhibiting constitutive expressor of PR (cpr)-like phenotypes, in that growth impairment of scd1-1 plants was genetically independent of constitutive immune response activation. For scd1-1, shift to elevated temperature or introduction of a mutant allele in Salicylic acid Induction-Deficient 2 (SID2) suppressed constitutive defense response activation. sid2-2 also repressed the resistance phenotype of scd1-1. Temperature shift and sid2-2, however, did not rescue conditional growth and sterility defects of scd1-1. These results implicate SCD1 in multiple cellular pathways, possibly by affecting different proteins. Overall, our studies identified a novel role for eukaryotic DENN proteins in immunity against bacteria.
Asymmetric dimethylarginine and M 30 concentrations in heart failure

DOI: 10.4328/JCAM.4992 Received: 23.03. 2017 Accepted: 07.05. 2017 Printed: 01.12. 2017 J Clin Anal Med 2017;8(suppl 4): 280-3 Corresponding Author: Halef Okan Doğan, Biyokimya Laboratuvarı, CumhuriyetÜniversitesi Tıp Fakültesi Hastanesi, Sivas, Merkez, Türkiye. T. : +90 3462191010 E-Mai: halefokan@gmail.com Öz Amaç: Kardiyovasküler hastalıkların gelişiminde apoptozun önemi vurgulanmaktadır. Caspase cleaved cytokeratin 18 (M30) apoptotik hücre ölümü sırasında salınan bir biyobelirteçtir. Bu çalışmada M30’un kalp yetmezliği hastalarındaki düzeyinin belirlenmesi ve M30’un asimetrik dimetilarjinin (ADMA) ile olan korelasyonun değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya 30 kalp yetmezliği hastası ve 30 sağlıklı kontrol dahil edildi ve çalışma populasyonundaki bireylerin serum M30 ve ADMA düzeyleri ölçüldü. Bulgular: Hastalardaki M30 (p=0.01) ve ADMA (p = 0.012) düzeyleri sağlıklı kontrol grubundan daha yüksek bulundu. Hastalarda M30 konsantrasyonu ile ADMA düzeyi arasında pozitif korelasyon saptandı (p < 0.001, r= 0.627) ancak M30 düzeyi ile N terminal pro brain natriuretic peptide (NT-pro-BNP) düzeyi arasında herhangi korelasyon saptanmadı. Tartışma: Çalışmamızdan elde edilen bulgular kalp yetmezliği hastalarında M30’un apoptotik serum biyobelirteci olabileceğini göstermektedir. Ayrıca hastalarda artan ADMA düzeyinin aktive ettiği apoptotik kaskadın kalp yetmezliğinin oluşum mekanizmasında rol oynadığı düşünülmektedir.
CATALYSIS FOR TRANSFORMING BIOMASS TO VALUE ADDED CHEMICALS

Although fossil fuels will continue to be the prime energy source for next few years, its limited reserves and environmental impact drives us to initiate the transition to renewable and clean energy resources. Among various renewable energy options, biomass occupies a unique position because it is, (i) most abundant and carbon neutral, (ii) acts as energy collector and storage system, (iii) the only large-scale energy source, (iv) available at low capital cost and (v) source of various value added chemicals, befitting to the concept of ‘Biorefinery’. This paper presents a summary of our recent work on catalyst and process development for conversion of biomass derived molecules such as glycerol, levulinic acid and furfural to the respective diols, ring lactones and heterocycles having applications in variety of sectors including fuel and commodity.
Computer Implementation of “ Rational Pigs Game ” Extended Model and Humans ' Decision-Making in Related Scenarios

This paper examines the well-known Rational Pigs Game (RPG) scenario from game theory where two boxed gluttons try to consume as much food as possible from a common source. In our expanded game version, we introduced a third glutton and formulated computer game for playing in the laboratory, based on our previously featured software engine called Autogenerator. Thanks to this mechanism, the game theory model of the RPG acquires the attributes of a computer game and it can run by interaction of people, players on their computers. A laboratory experiment was performed where a total of 60 players using computers were engaged in decision-making in the role of gluttons. The players’ behavior allowed us to gain useful insights into their rationalization, decision-making and learning processes.
Implication of CXCL 5 ( epithelial neutrophil-activating peptide 78 ) in the development of insulin resistance in patients with rheumatoid arthritis

Objective The chemokine molecule CXCL5 (C-X-C motif chemokine ligand 5, also known as epithelial neutrophil activating peptide 78 -ENA78-) constitutes a link between obesity, inflammation and insulin resistance (IR) in the general population. CXCL5 has also been found to play a role in rheumatoid arthritis (RA) pathogenesis. Since chronic inflammation promotes IR and impairs pancreatic beta cell function in RA patients, we assessed the role of CXCL5 in the development of IR in RA.
Visualizing thai stock performance using parallel coordinates

Data visualization plays a significant role in investment activities, since it directly provides the decision-relevant information to investors. The traditional Stock Chart provides limited information to investors as it only displays the price changes of the stock over a period of time. More information could be incorporated in the plot such as the return of a stock, the risk of a stock and the performance of the corporation issuing the stock. Based on the information what an investor concerns most about investment activities, a new style visualization method based on Parallel Coordinates is proposed. This paper will describe this visualization technique in the stock chart context and explain the Data Envelopment Analysis (DEA) model used to construct the Parallel Coordinate. In addition, the benefits of the Parallel Coordinates are illustrated.
Analysis of Fetal Development Using Ultrasound Images

The analysis of fetus behavior is observed using the medical imaging tool called the Ultrasound imaging. The quality of these images tend be low due the presence of noise. Hence, this noise needs to be suppressed or removed. Pre-processing steps are done before the fetal development analysis. The system helps the pregnant women to take care of her health with the suggestion from the expert.
Objective measures of breathy voice quality obtained using an auditory model.

While several acoustic measures have been proposed to quantify listener ratings of breathy voice quality, most have failed to give a consistent and high correlation with perceptual ratings of breathiness. One reason for these limitations is that most acoustic measures do not address the nonlinear processes that occur in the peripheral auditory system during the auditory perceptual process. It was hypothesized that modeling such nonlinear events during signal processing may provide objective parameters that better correspond to perceptual ratings of breathy voice quality. Ten listeners rated 27 voice stimuli using a five-point rating scale. Acoustic measures were determined from these stimuli and were selected based on their history of having a moderate to strong correlation to perceptual ratings of breathiness. The stimuli were also analyzed using an auditory model proposed by Moore, Glasberg, and Baer [J. Audio Eng. Soc. 45(4), 224-239 (1997)], and new measures were calculated from the output of this model. These measures included the partial loudness of the signal and the loudness of the aspiration noise. Measures obtained from the output of the auditory model were found to account for a high amount of variance in the perceptual ratings of breathiness.
Development and storage stability of RTE Bengal gram ( Cicer arietinum ) based spiced snacks –

A Ready-to-Eat (RTE) spiced Bengal gram snack (Chana Nibble) with 50.33±0.15% moisture, 17.92±1.12% protein, 9.36±0.56% crude fat, 20.39±1.12% carbohydrate, 2.27±0.05% ash, 16.54±1.25% total dietary fibers was developed. The effect of different heat treatments & preservatives on the RTE Bengal gram snack was evaluated with a view to stabilize the product at ambient storage conditions for more than three months. The process of Chana Nibble was based on soaking, cooking, and seasoning followed by in-pack preservation techniques. The product scored superior acceptability (8.3±0.1) on 9 point hedonic scale. Different heat treatments applied to the product packed in PP pouches (75 μ thickness) were able to increase shelf life from 2 days to 115 days with respect to microbial spoilage at ambient temperature. Thermal treatment with steam under pressure at 121±0.1°C for 15 minutes was able to not only prevent microbial spoilage but also to impart shelf stability to the product for more than 12-14 weeks whereas thermal treatment with boiling water was able to stabilize product for 7 days and heat treatment by heating the product in cabinet dryer at 90°C for 120 minutes remained stable for 12 weeks with respect to microbial spoilage.
Tackling Resource Interoperability : Principles , Strategies and Models

In order to accommodate the flexible exploitation and creation of knowledge resources in text and data mining (TDM) workflows, the TDM architecture will need to enable the re-use of resources encoding linguistic/terminological/ontological knowledge, such as ontologies, thesauri, lexical databases and the output of linguistic annotation tools. For this purpose resource interoperability is required in order to enable text mining tools to uniformly handle these knowledge resources and operationalise interoperable workflows. The Open Mining Infrastructure for Text and Data (OpenMinTeD) aims at defining this interoperability by adhering to standards for modelling and knowledge representation, and by defining a mapping structure for the harmonisation of information contained in heterogeneous resources.