Miracle-dz/UniFAR-FTUs huggingface dataset:
Suicidal ideation among suburban adolescents: The influence of school bullying and other mediating risk factors

Objective: Prior research has identified multiple factors that influence suicidal ideation (SI) among bullied youth. The effects of school bullying on SI cannot be considered in isolation. In this study, we examined the influence of school bullying on SI, through a constellation of risks, which include depressive and anxiety symptoms, family conflict, and alcohol, tobacco, and other drug (ATOD) use. We also provide recommendations for therapists working with bullied youth. Method: Our sample consisted of 488 adolescents (ages 10-18 years) from a northern New Jersey, United States suburban community. Students were recruited through the district’s physical education and health classes. Students responded to multiple measures, which included family cohesion/conflict, ATOD use, mental health indicators, SI, and school bullying experiences. Following preliminary analyses, several logistic regression models were used to assess the direct influence of bullying on SI, as well as the unique effects of family conflict, depressive and anxiety symptoms, and substance use. In addition, a parallel multiple mediating model with the PROCESS macro in SPSS was used to further assess mediating effects. Results: Logistic regression results indicated that school bullying increased the odds of SI among males and females and that when mediating variables were added to the model, bullying no longer had a significant influence on SI. Overall, these results display that for both males and females, school bullying was a significant contributor to SI. Results from the parallel multiple mediating model further illustrated the mediating effects that family conflict, depression, and ATOD use had between bullying and SI. Some variation was noted based on gender. Conclusion: This study draws attention to the multiple experiences associated with school bullying on SI, and how these results may differ by gender. The results of this study are particularly important for those working directly and indirectly with bullied youth. Therapists that engage bullied youth need to consider the multiple spheres of influence that may increase SI among male and female clients. To holistically and adequately assess SI among bullied youth, therapists must also consider how these mechanisms vary between gender groups.
Identifications small molecules inhibitor of p53-mortalin complex for cancer drug using virtual screening

Mortalin was over expressed in tumor cells and bind to p53 protein. This interaction was suggested to promote sequestration of p53 in the cytoplasm, thereby inhibiting its nuclear activity. The p53 is a tumor suppressor that is essential for the prevention of cancer development and loss of p53 function is one of the early events in immortalization of human cells. Therefore, abrogation p53-mortalin interaction using small molecule is guaranteed stop cancer cell grow. However study interaction of p53-mortalin, and its inhibition using small molecule is still challenging because specific site of mortalin that bind to p53, vice versa, is still debatable. This study has aims to analyze the p53-binding site of mortalin using molecular docking and to screen drug-like compounds that have potential as inhibitors of p53-mortalin interaction using virtual screening. The result showed that the lowest energy binding of p53-mortalin complex is -31.89 kcal/mol, and p53 protein bind to substrate binding domain of mortalin (THR433; VAL435; LEU436; LEU437; PRO442; ILE558; LYS555). Furthermore, the p53-binding domain of mortalin was used as receptor to screen 9000 drug-like compounds from ZINC database using molecular docking program Auto Dock Vina in PyRx 0.8 (Virtual Screening Tools). Here, we have identified three drug-like compounds that are ZINC01019934, ZINC00624418 and ZINC00664532 adequate to interrupt stability of p53-mortalin complex that warrant for anticancer agent.
CYTODIFFERENTIATION DURING SPERMIOGENESIS IN LUMBRICUS TERRESTRIS

The structural changes during spermiogenesis were studied on developing spermatids in seminal vesicles and receptacles of Lumbricus terrestris fixed in glutaraldehyde-osmium tetroxide and embedded in Epon-Araldite. The centriole plays a prominent role in the morphogenesis and organization of the microtubules of the manchette and flagellum. Microtubules arising from the centriole extend anteriorly to encase the developing middle piece, the nucleus, and the acrosome. The manchette not only provides a supporting framework for the cell during elongation, but also may provide the motive force for the elimination of both nucleoplasm and cytoplasm. The manchette participates in segregation and elimination of the nuclear vesicle that contains the nonchromatin nucleoplasm. Compartmentalization and conservation may also be a function of the manchette since those elements which remain within the framework of microtubules are retained, while all the cytoplasm outside the manchette is discarded. At maturation, the endoplasmic reticulum plays a key role in dismantling the manchette and reducing the cytoplasm external to it. During the early stages of middle-piece formation, six ovoid mitochondria aggregate at the posterior pole of the spermatid nucleus. Concurrent with manchette formation, the mitochondria are compressed laterally into elongate wedge-shaped components, and their outer limiting membranes fuse to form an hexagonal framework that surrounds the dense intramitochondrial matrices. Dense glycogen granules are arranged linearly between the peripheral flagellar tubules and the outer membrane of the mature sperm tail.
Moral Impression Management

Previous research revealed that emphasizing morality increases motivational processes that improve people’s task performance. Here we examined whether this emphasis differentially affects people’s performance in the presence of an in-group compared to an out-group member. Ostensibly while being evaluated by another person, participants performed an Implicit Association Test that was framed as a test of either their morality or their competence. Results showed a smaller bias toward Muslim women in the morality compared to the competence condition, but this effect was more pronounced when participants were evaluated by a member of their minimal in-group. Moreover, in that same condition, event-related potentials revealed increased perceptual attention (N1) and affected conflict and response monitoring (N450 and error-related negativity). These findings suggest that being moral is especially important when monitored by the in-group and reveal the cognitive processes associated with controlling intergroup bias in a social situation.
Adapting Life-Review Therapy for Elderly Female Survivors of Childhood Sexual Abuse

The author describes the use of life-review therapy in the resolution of childhood sexual abuse with older women through four case illustrations of older women in rural Appalachia. Therapists must take great care to preserve functional defense mechanisms for the survivor, utilize nonverbal techniques to process intense feelings and assist in the memory retrieval process, and incorporate creative techniques to address family-of-origin issues. The author discusses the importance of choice in empowering clients, even when clients reject treatment as an expression of empowerment.
Demands, resources, and work ability: A cross-national examination of health care workers

Understanding work ability, with the goal of promoting it, is important for individuals as well as organizations. It is especially important to study work ability in health care workers, who face many work-related challenges that may threaten work ability. We studied various job demands, job resources, and interactions of demands and resources relating to work ability using the Job Demands–Resources model as a framework. Acute care health care workers from six nations (US, Australia, UK, Brazil, Croatia, and Poland) completed a survey. Role demands related to work ability in the Australia sample only, and supervisor support related to work ability in the Australia sample only. Yet, high levels of supervisor support significantly moderated (buffered) negative relationships between physical demands and work ability in the US sample, along with negative relationships between role demands and work ability in both the Croatia and UK samples. Skill discretion related to work ability in every nation sample, and therefore appears to be particularly important to work ability perceptions. In addition, skill discretion moderated (buffered) a negative relationship between role demands and work ability in the Australia sample. We therefore recommend that interventions to help preserve or improve work ability target this important job resource.
Differential Regulation of Vitamin D Receptor (VDR) by the p53 Family

p63 and p73, members of the p53 family, have been shown to be functionally distinct from p53. Vitamin D receptor (VDR) is a ligand (vitamin D3)-dependent transcription factor, which is shown to play a major role in calcium homeostasis and keratinocyte differentiation. Vitamin D and its analogues in combination with DNA-damaging agents are extensively used for cancer chemotherapy. In this report, we examined whether p53 affects p63-mediated induction of VDR and studied the effect of DNA damage on VDR induction in p53 null cell lines. Our results demonstrate that p53 itself does not induce VDR expression, nor does it affect p63-mediated VDR induction in the cell lines tested in this study. Furthermore, we observed p53-independent activation of VDR upon DNA damage and associated the induction of VDR to p73. We have demonstrated that ectopic expression of various p73 isoforms can induce VDR expression. Inhibition of p73 in cells treated with DNA-damaging agents exhibited decreased VDR expression. Finally, we show that upon DNA damage, induction of VDR sensitizes the cells to vitamin D treatment. In conclusion, our results indicate that VDR is regulated by p63 and p73 and that the induction of VDR expression upon DNA damage is p73-dependent.
Virtual touch screen “VIRTOS” implementing virtual touch buttons and virtual sliders using a projector and camera

We propose a large interactive display with virtual touch buttons and sliders on a pale-colored flat wall. Our easy-to-install system consists of a front projector and a single commodity camera. A button touch is detected based on the area of the shadow cast by the user's hand; this shadow becomes very small when the button is touched. The shadow area is segmented by a brief change of the button to a different color when a large foreground (i.e., the hand and its shadow) covers the button region. Therefore, no time consuming operations, such as morphing or shape analysis, are required. Background subtraction is used to extract the foreground region. The reference image for the background is continuously adjusted to match the ambient light. Our virtual slider is based on this touch-button mechanism. When tested, our scheme proved robust to differences in illumination. The response time for touch detection was about 150 ms. Our virtual slider has a quick response and proved suitable as a controller for a Breakout-style game.
The Parallel Redundancy Protocol for industrial IP networks

The “Parallel Redundancy Protocol” (PRP) according to IEC 62439-3 realizes active network redundancy by packet duplication over two independent networks that operate in parallel. It has been specifically designed for industrial networks to meet highest availability requirements. In case of a single network failure, seamless redundancy is provided for data communication between PRP nodes that are connected to both networks. However, PRP was designed as a layer 2 Ethernet protocol that is transparent to higher protocol layers. In its current version, PRP is not able to support IP routing. This is because an IP router would change the source MAC address field of the Ethernet header which is used by a PRP receiver node for duplicate detection. In this work we propose and discuss a novel approach that keeps the PRP duplicate identification information across IP router boundaries.
EEG Source Localization and Global Dimensional Complexity in High- and Low- Hypnotizable Subjects: A Pilot Study

Individuals differ in hypnotizability. Information on hypnotizability-related EEG characteristics is controversial and incomplete, particularly on intracerebral source localization and EEG dimensionality. 19-channel, eyes-closed resting EEGs from right-handed, healthy, 8 high- and 4 low-hynotizable subjects (age: 26.7 ± 7.3 years) were analyzed. Hypnotizability was rated after the subjects’ ability to attain a deep hypnotic stage (amnesia). FFT Dipole Approximation analysis in seven EEG frequency bands showed significant differences (p < 0.04) of source gravity center locations for theta (6.5–8 Hz, more posterior and more left for highs), beta-1 and beta-2 frequencies (12.5–18 and 18.5–21 Hz; both more posterior and more right for highs). Low Resolution Electromagnetic Tomography (LORETA) specified the cortical anteriorization of beta-1 and beta-2 in low hypnotizables. Power spectral analysis of Global Field Power time series (curves) showed no overall power differences in any band. Full-band Global Dimensional Complexity was higher in high-hypnotizable subjects (p < 0.02). Thus, before hypnosis, high and low hypnotizables were in different brain electric states, with more posterior brain activity gravity centers (excitatory right, routine or relaxation left) and higher dimensional complexity (higher arousal) in high than low hypnotizables.
Cortical prediction markets

We investigate cortical learning from the perspective of mechanism design. First, we show that discretizing standard models of neurons and synaptic plasticity leads to rational agents maximizing simple scoring rules. Second, our main result is that the scoring rules are proper, implying that neurons faithfully encode expected utilities in their synaptic weights and encode high-scoring outcomes in their spikes. Third, with this foundation in hand, we propose a biologically plausible mechanism whereby neurons backpropagate incentives which allows them to optimize their usefulness to the rest of cortex. Finally, experiments show that networks that backpropagate incentives can learn simple tasks.
CONSCIOUS APPRAISAL AND THE MODIFICATION OF AUTOMATIC PROCESSES IN ANXIETY

Intrusive thoughts, flashbacks, panic attacks and sudden physiological arousal are each experienced as involuntary, are difficult to control, and lead to considerable distress. Such observations have led to the suggestion that anxiety disorders are associated with the operation of automatic information-processing biases. Clinical and experimental evidence for this proposal is reviewed and three different classes of routes to the development and modification of these automatic processes are described: an innate route, repetition/habituation, and conscious appraisal. The review focuses in particular on the third route, proposing that automatic processing biases can be altered by accessing and modifying conscious appraisals of internal and external events. Indirect evidence is provided by selective attention paradigms in anxiety, treatment studies and clinical observations, although further research will be necessary for a direct test of the pathway. The implications for the theory and practice of psychological therapy for anxiety disorders are described.
Will Educational Materials Reduce Negative Effects of Exposure to Sexual Violence

To study the effects of information designed to dissociate violence from sexuality on attitudes toward sexual violence, we constructed two brief films about the importance of concern for one's sexual partner and about the impact of rape on its victims. Both films were intended to modify mechanisms hypothesized to underlie associations between violence and sexuality by increasing sensitivity toward violent behavior and reducing aggressive tendencies associated with sexual cues. One of these films, or no informational film, was presented before showing one third of each group a commercial film that depicted sexual violence, nonviolent sexuality, or nonviolent, nonsexual material. Compared to the unbriefed group, the briefed groups showed a significant decline in beliefs in rape myths. They also reported greater empathy toward an alleged victim of rape, a greater tendency to find the accused assailant guilty, greater sensitivity to filmed violence against women, and greater physiological-emotional repulsion .
Loop-Mediated Isothermal Amplification Targeting 18S Ribosomal DNA for Rapid Detection of Acanthamoeba

Amoebic keratitis (AK) caused by Acanthamoeba is one of the most serious corneal infections. AK is frequently misdiagnosed initially as viral, bacterial, or fungal keratitis, thus ensuring treatment delays. Accordingly, the early detection of Acanthamoeba would contribute significantly to disease management and selection of an appropriate anti-amoebic therapy. Recently, the loop-mediated isothermal amplification (LAMP) method has been applied to the clinical diagnosis of a range of infectious diseases. Here, we describe a rapid and efficient LAMP-based method targeting Acanthamoeba 18S rDNA gene for the detection of Acanthamoeba using clinical ocular specimens in the diagnosis of AK. Acanthamoeba LAMP assays detected 11 different strains including all AK-associated species. The copy number detection limit for a positive signal was 10 DNA copies of 18S rDNA per reaction. No cross-reactivity with the DNA of fungi or other protozoa was observed. The sensitivity of LAMP assay was higher than those of Nelson primer PCR and JDP primer PCR. In the present study, LAMP assay based on directly heat-treated samples was found to be as efficient at detecting Acanthamoeba as DNA extracted using a commercial kit, whereas PCR was only effective when commercial kit-extracted DNA was used. This study showed that the devised Acanthamoeba LAMP assay could be used to diagnose AK in a simple, sensitive, and specific manner.
Model Checking Large Network Protocol Implementations

Network protocols must work. The effects of protocol specification or implementation errors range from reduced performance, to security breaches, to bringing down entire networks. However, network protocols are difficult to test due to the exponential size of the state space they define. Ideally, a protocol implementation must be validated against all possible events (packet arrivals, packet losses, timeouts, etc.) in all possible protocol states. Conventional means of testing can explore only a minute fraction of these possible combinations. This paper focuses on how to effectively find errors in large network protocol implementations using model checking, a formal verification technique. Model checking involves a systematic exploration of the possible states of a system, and is well-suited to finding intricate errors lurking deep in exponential state spaces. Its primary limitation has been the effort needed to use it on software. The primary contribution of this paper are novel techniques that allow us to model check complex, real-world, well-tested protocol implementations with reasonable effort. We have implemented these techniques in CMC, a C model checker [30] and applied the result to the Linux TCP/IP implementation, finding four errors in the protocol implementation.
Loss of regional accent after damage to the speech production network

Lesion-symptom mapping studies reveal that selective damage to one or more components of the speech production network can be associated with foreign accent syndrome, changes in regional accent (e.g., from Parisian accent to Alsatian accent), stronger regional accent, or re-emergence of a previously learned and dormant regional accent. Here, we report loss of regional accent after rapidly regressive Broca’s aphasia in three Argentinean patients who had suffered unilateral or bilateral focal lesions in components of the speech production network. All patients were monolingual speakers with three different native Spanish accents (Cordobés or central, Guaranítico or northeast, and Bonaerense). Samples of speech production from the patient with native Córdoba accent were compared with previous recordings of his voice, whereas data from the patient with native Guaranítico accent were compared with speech samples from one healthy control matched for age, gender, and native accent. Speech samples from the patient with native Buenos Aires’s accent were compared with data obtained from four healthy control subjects with the same accent. Analysis of speech production revealed discrete slowing in speech rate, inappropriate long pauses, and monotonous intonation. Phonemic production remained similar to those of healthy Spanish speakers, but phonetic variants peculiar to each accent (e.g., intervocalic aspiration of /s/ in Córdoba accent) were absent. While basic normal prosodic features of Spanish prosody were preserved, features intrinsic to melody of certain geographical areas (e.g., rising end F0 excursion in declarative sentences intoned with Córdoba accent) were absent. All patients were also unable to produce sentences with different emotional prosody. Brain imaging disclosed focal left hemisphere lesions involving the middle part of the motor cortex, the post-central cortex, the posterior inferior and/or middle frontal cortices, insula, anterior putamen and supplementary motor area. Our findings suggest that lesions affecting the middle part of the left motor cortex and other components of the speech production network disrupt neural processes involved in the production of regional accent features.
Do Sticky Elites Produce Online Knowledge of Higher Quality?

Online knowledge production sites, such as Wikipedia or Stack Overflow, are dominated by small groups of contributors. How does this affect knowledge production and its quality? Does the persistent presence of some key contributors among the most productive members improve or not the quality of the knowledge, considered in the aggregate? The present paper considers these issues by correlating week-by-week value changes in contribution unevenness, elite resilience (stickiness), and content quality. The goal is to detect if and how changes in social structural variables may influence the quality of the knowledge produced by online knowledge production sites. The paper addresses such question by an extensive data analysis carried out on the datasets of two representative sites: Wikipedia and Stack Overflow. Results from the analysis show that on Stack Overflow both unevenness and elite stickiness have a curvilinear effect on quality. Quality is optimized at specific levels of elite stickiness and unevenness. At the same time, on Wikipedia, quality increases linearly with a decline on entropy, overall, and with an increase in stickiness in the maturation phase, after an entropy peak is reached.
The School as a Learning Organization

Any given school environment represents the interplay of school cultural values; the curricular, organizational, and human resources of the school; and student productivity, all seen through the lens of student, teacher, and parent perceptions of the school's climate. The environment of the school is not the actual cultural norms and expectations as lived and experienced but also the perception of that reality by the "significant others" of the school—student, teacher, and parent/community. The perception, in fact, is often more significant than the reality, since people act and react as they perceive something to be.