Miracle-dz/UniFAR-FTUs huggingface dataset:
The professional socialization of the athletic trainer serving as a preceptor.

CONTEXT The role of the preceptor requires the athletic trainer to be versed in effective instructional techniques, supervisory skills, and communication skills beyond his or her competence as an athletic trainer, but many have not received formal training in educational techniques. OBJECTIVE To gain a better understanding about the professional socialization process for the athletic trainer assuming the role of the preceptor. DESIGN Qualitative study. SETTING Athletic training education programs. PATIENTS OR OTHER PARTICIPANTS Twenty-four preceptors (11 men, 13 women; age = 32 ± 7 years, clinical experience = 9 ± 6 years, preceptor experience = 5 ± 3 years) employed in the collegiate (n = 12) or secondary school (n = 12) setting. DATA COLLECTION AND ANALYSIS We gathered data using asynchronous, in-depth interviewing via QuestionPro. We analyzed data using a general inductive approach to uncover the dominant themes. Credibility was secured by using consistency and stakeholder checks and a peer review. RESULTS We identified 2 main themes by which preceptors develop in their roles as clinical instructors: formal processes and informal processes. The participants used observations, previous experiences or interactions with role models, and self-reflection and evaluation as informal socialization processes. Formal socialization processes included preceptor training/workshops, professional development, and formal teacher certification. CONCLUSIONS Athletic trainers who serve as preceptors learned their roles by a combination of informal and formal processes. Preceptor training sessions appeared to be effective in initially helping preceptors learn their responsibilities, whereby more informal processes seemed to help them refine their skills. Furthermore, one socialization strategy did not appear to dominate role learning; rather, a combination of several processes fostered an understanding.
Exploring Patient Activation in the Clinic

Objective. To further conceptualize and operationalize patient activation (PA), using measures from patient, physician, and researcher perspectives. Data Source/Study Setting. Multimethod observation in 2010 within a family medicine clinic. Study Design. Part of an intervention with 130 patients with type 2 diabetes, this observational study further looked at PA in 19 physician–patient dyads. Data Collection. Observations occurred in a teaching hospital, which served as recruiting and study site. Principal Findings. PA correlated with knowledge, self-efficacy, promotion orientation, and exercise intent. Patient-reported PA did not correlate with researcher-observed or physician-reported PA behavior. Researcher-observed PA correlated with physician-observation items. Conclusions. Results provide evidence for measuring different perspectives in studies of PA. When patients report they are activated in self-management, behavior does not indicate they are active in clinical communication, a critical component of collaborative decision making.
The glycopeptide vancomycin does not enhance toll-like receptor 2 (TLR2) activation by Streptococcus pneumoniae.

OBJECTIVES The exposure of Streptococcus pneumoniae to cell-wall-active antibiotics in vivo and in vitro results in the release of bacterial components that can induce proinflammatory activation of human cells via toll-like receptor 2 (TLR2). The aim of this study was to compare the activation of human TLR2 pathways after exposure of S. pneumoniae to faropenem, cefotaxime and vancomycin. MATERIALS AND METHODS Streptococcus pneumoniae D39 was exposed to cefotaxime, faropenem or vancomycin for 6 h during lag or early log phase growth. IL-8 promoter activity of HeLa cells was measured using a dual luciferase reporter plasmid system. HeLa cells were transfected with an expression vector containing TLR2/CD14, or empty vector/CD14 and IL-8 promoter activity was measured using luminescence. Cells were stimulated with antibiotic-treated bacteria, untreated bacteria or medium-only controls. RESULTS Lag phase S. pneumoniae treated at sub-MIC (1/8 MIC) cefotaxime or faropenem induced 11-fold and 8-fold increases, respectively, in TLR2-mediated IL-8 promoter activity when compared with untreated bacteria. Early log MIC cefotaxime or faropenem-treated bacteria also enhanced TLR2 activation by 3-fold and 4-fold, respectively, when compared with untreated bacteria. Vancomycin treatment had no effect on TLR2 induction at any growth stage or MIC ratio tested. CONCLUSIONS beta-Lactam antibiotics induce surface changes and release of cell wall structures from bacteria that are proinflammatory via TLR2, but the glycopeptide vancomycin does not.
Improvement of sensitivities of concentric single-layer elements for the design of reflectarrays using split double-ring

In this paper, a broadband single-layer microstrip reflectarray element composed of a split double ring patch printed on composite substrate of low-cost, lossy materials FR4 and foam is presented and compared with the double square ring patch. The analyses are performed using the CST Microwave Studio software package. The proposed structure offers a slope value of 60°/mm, while the phase range is 450°. The 1 dB drop gain bandwidth of 19.5% over the frequency range of 12.4 GHz -15.1 GHz.
Distinct Interethnic Differences in Immunoglobulin G Class/Subclass and Immunoglobulin M Antibody Responses to Malaria Antigens but not in Immunoglobulin G Responses to Nonmalarial Antigens in Sympatric Tribes Living in West Africa

The well‐established relative resistance to malaria observed in the Fulani as compared with other sympatric tribes in West Africa has been attributed to their higher levels of serum immunoglobulin (Ig) G antibodies to malarial antigens. In this study, we confirm and extend the previous findings by analyses of the levels of IgM, IgG and IgG subclasses of anti‐malarial antibodies in asymptomatic individuals of different sympatric tribes in Burkina Faso (Fulani/Mossi) and Mali (Fulani/Dogon). The Fulani showed significantly higher median concentrations of anti‐malarial IgG and IgM antibodies than the sympatric tribes at both locations. Although the overall subclass pattern of antibodies did not differ between the tribes, with IgG1 and IgG3 as dominant, the Fulani showed consistently significantly higher levels of these subclasses as compared with those of the non‐Fulani individuals. No significant differences were seen in the levels of total IgG between the tribes, but the Fulani showed significantly higher levels of total IgM than their neighbours in both countries. While the antibody levels to some nonmalarial antigens showed the same pattern of differences seen for antibody levels to malaria antigens, no significant such differences were seen with antibodies to other nonmalarial antigens. In conclusion, our results show that the Fulani in two different countries show higher levels of anti‐malarial antibodies than sympatric tribes, and this appears not to be a reflection of a general hyper‐reactivity in the Fulani.
Atteintes amygdaliennes et troubles émotionnels dans la maladie d'Alzheimer : apport de nouvelles pistes pour le diagnostic

Le diagnostic de la maladie d'« Alzheimer » (MA) repose essentiellement sur des tests neuropsychologiques, demontrant d'importants deficits mnesiques en lien avec l'atrophie de l'hippocampe. Parallelement a cela, l'existence d'une atteinte precoce de l'amygdale a tres recemment ete proposee dans une serie d'etudes, suggerant que cette structure pourrait etre un marqueur neuro-anatomique de l'entree dans la maladie. Les etudes ayant evalue les repercussions emotionnelles de ces atteintes amygdaliennes n'ont neanmoins pas permis d'aboutir a l'identification d'un profil convergent de deficits. L'objectif de cette these a donc ete de demontrer l'existence d'une atteinte de l'amygdale a un stade precoce de la MA entrainant des modifications des traitements emotionnels. Dans une premiere etude en neuroimagerie structurelle, nous avons montre des arguments robustes quant a l'existence d'atteintes anatomiques de l'amygdale chez des patients legerement atteints par la maladie. L'amplitude de cette atrophie s'est averee etre un indicateur particulierement sensible du niveau general d'atteintes cognitives mesurees chez nos patients. Dans les etudes suivantes, nous nous sommes interesses aux repercussions de cette atteinte sur des activites cognitives sous-tendues plus directement par le fonctionnement de cette structure : les traitements emotionnels. Par l'elaboration d'une meta-analyse, nous avons pu identifier un deficit precoce de la reconnaissance des emotions. Nous avons de plus demontre que les troubles cognitifs des patients expliquaient en partie le deficit emotionnel, sans toutefois l'expliquer dans sa totalite. Enfin, une serie d'etudes comportementales et en neuroimagerie fonctionnelle, a permis de confirmer que les atteintes anatomiques s'accompagnaient bien d'un dysfonctionnement de l'amygdale entrainant des deficits emotionnels, en particulier dans les mecanismes a l'origine de l'extraction spontanee de la saillance emotionnelle. L'ensemble de nos donnees convergent vers l'idee que l'atteinte amygdalienne et les alterations des mecanismes emotionnels seraient une piste prometteuse afin de preciser le diagnostic actuel de la MA.
Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system that causes motor, sensory, and cognitive deficits. The present study characterized demyelinated lesions in the cerebral cortex of MS patients. One hundred twelve cortical lesions were identified in 110 tissue blocks from 50 MS patients. Three patterns of cortical demyelination were identified: type I lesions were contiguous with subcortical white matter lesions; type II lesions were small, confined to the cortex, and often perivascular; type III lesions extended from the pial surface to cortical layer 3 or 4. Inflammation and neuronal pathology were studied in tissue from eight and seven patients, respectively. Compared to white matter lesions, cortical lesions contained 13 times fewer CD3‐positive lymphocytes (195 vs 2,596/mm3 of tissue) and six times fewer CD68‐positive microglia/macrophages (11,948 vs 67,956/mm3 of tissue). Transected neurites (both axons and dendrites) occurred at a density of 4,119/mm3 in active cortical lesions, 1,107/mm3 in chronic active cortical lesions, 25/mm3 in chronic inactive cortical lesions, 8/mm3 in myelinated MS cortex, and 1/mm3 in control cortex. In active and chronic active cortical lesions, activated microglia closely apposed and ensheathed apical dendrites, neurites, and neuronal perikarya. In addition, apoptotic neurons were increased significantly in demyelinated cortex compared to myelinated cortex. These data support the hypothesis that demyelination, axonal transection, dendritic transection, and apoptotic loss of neurons in the cerebral cortex contribute to neurological dysfunction in MS patients.
Tracheal aspirate VEGF and sphingolipid metabolites in the preterm infant with later development of bronchopulmonary dysplasia

Vascular endothelial growth factor (VEGF) and sphingolipid metabolites, sphingosine 1‐phosphate (S1P), and ceramides are important to lung development and repair. We hypothesized specific sphingolipid and VEGF alterations would be associated with BPD development and aimed to investigate the early tracheal aspirate (TA) VEGF and S1P relationship with later diagnosis of preterm infant bronchopulmonary dysplasia, BPD.
Drug review: Pazopanib

Pazopanib (Votrient®) is an oral small-molecule multi-kinase inhibitor that primarily inhibits vascular endothelial growth factor receptor-1, -2 and -3, platelet endothelial growth factor receptor-α, and -β, and the stem-cell factor receptor c-kit. In preliminary experiments using angiogenesis models with mice and rabbits, pazopanib inhibited angiogenesis caused by combined vascular endothelial growth factor and basic fibroblast growth factor. Although pazopanib was developed as a therapeutic agent against various tumors, it is currently approved in many countries for advanced soft-tissue sarcoma and renal cell carcinoma. The importance of pazopanib has been acknowledged, with positive results demonstrated in large-scale clinical trials involving patients with soft-tissue sarcoma and renal cell carcinoma. However, adverse events such as liver dysfunction and hypertension are common, often necessitating treatment discontinuation. These adverse events are generally manageable, and from the perspective of health-related quality of life and cost-effectiveness, pazopanib provides an improvement in quality-adjusted life years and decreases the treatment cost compared with other alternatives. In this review, we present the results of clinical trials and discuss the pharmacological action of pazopanib, with the aim of evaluating its current state by examining various associated issues.
Configurations of laser interference lithography for 2D/3D nanostructures of optical functional materials

This paper presents various methods of multi-beam laser interference lithography to form dense periodical nanostructures suitable for many optical functional materials or devices. Research results show that 2D and 3D inference patterns could be generated cheaply and easily by exposing the photosensitive materials using the periodically changed light intensity distributions of multi-beam interference fields. Different configurations of multi-beam interference setups are introduced. Simulation and experimental results are also obtained. It can be seen that the experimental results are in accordance with the physical principle, and the simulation results have also given the expected results clearly.
A preliminary comparison of front and back squat exercises.

The purpose of this study was to compare the knee extensor demands and low back injury risks of the front and back squat exercises. Highly strength-trained college-aged males (n = 8), who performed each type of squat (Load = 75% of front squat one repetition maximum), were filmed (50 fps) from the sagittal view. The body was modeled as a five link system. Film data were digitized and reduced through Newtonian mechanics to obtain joint forces and muscle moments. Mean and individual subject data results were examined. The maximum knee extensor moment comparison indicated similar knee extensor demands, so either squat exercise could be used to develop knee extensor strength. Both exercises had similar low back injury risks for four subjects, but sizable maximum trunk extensor moment and maximum lumbar compressive and shear force differences existed between the squat types for the other subjects. The latter data revealed that with the influence of trunk inclination either exercise had the greatest low back injury risk (i.e., with greater trunk inclination: greater trunk extensor demands and lumbar shear forces, but smaller lumbar compressive forces). For these four subjects low back injury risk was influenced more by trunk inclination than squat exercise type.
Coxiella burnetii Avirulent Nine Mile Phase II Induces Caspase-1-Dependent Pyroptosis in Murine Peritoneal B1a B Cells

ABSTRACT Our recent study demonstrated that virulent Coxiella burnetii Nine Mile phase I (NMI) is capable of infecting and replicating within peritoneal B1a cells and that B1a cells play an important role in host defense against C. burnetii infection in mice. However, it remains unknown if avirulent Nine Mile phase II (NMII) can infect and replicate in B1a cells and whether NMI and NMII can differentially interact with B1a cells. In this study, we examined if NMI and NMII can differentially modulate host cell apoptotic signaling in B1a cells. The results showed that NMII induced dose-dependent cell death in murine peritoneal B1a cells but NMI did not, suggesting that NMI and NMII may differentially activate host cell apoptotic signaling in B1a cells. Western blotting indicated that NMII-induced B1a cell death was not dependent on either caspase-3 or PARP-1 cleavage, but cleavage of caspase-1 was detected in NMII-infected B1a cells. In addition, inhibition or deficiency of caspase-1 activity blocked NMII-induced B1a cell death. These results suggest that NMII induces a caspase-1-dependent pyroptosis in murine peritoneal B1a cells. We also found that heat-killed NMII and type 4 secretion system (T4SS) mutant NMII were unable to induce B1a cell death and that NMII infection did not induce cell death in peritoneal B1a cells from Toll-like receptor 2 (TLR-2)- or NLRP3 inflammasome-deficient mice. These data suggest that NMII-induced caspase-1-dependent pyroptosis may require its T4SS and activation of the TLR-2 and NLRP3 signaling pathways.
Does diabetes mellitus‐induced bladder remodeling affect lower urinary tract function?: ICI‐RS 2011

Due to an increase in aging population and changing eating habits diabetes mellitus (DM) type II is a rapidly increasing condition worldwide. Although not so detrimental as other co‐morbidities, uropathy contributes to a significantly reduced quality‐of‐life in those affected. The purpose of this ICS‐RS report is to highlight clinical and basic research data to outline directions for further research and possible treatment approaches.
Neurophysiological mechanisms of emotion regulation for subtypes of externalizing children

Children referred for externalizing behavior problems may not represent a homogeneous population. Our objective was to assess neural mechanisms of emotion regulation that might distinguish subtypes of externalizing children from each other and from their normal age mates. Children with pure externalizing (EXT) problems were compared with children comorbid for externalizing and internalizing (MIXED) problems and with age-matched controls. Only boys were included in the analysis because so few girls were referred for treatment. We used a go/no-go task with a negative emotion induction, and we examined dense-array EEG data together with behavioral measures of performance. We investigated two event-related potential (ERP) components tapping inhibitory control or self-monitoring—the inhibitory N2 and error-related negativity (ERN)—and we constructed source models estimating their cortical generators. The MIXED children's N2s increased in response to the emotion induction, resulting in greater amplitudes than EXT children in the following trial block. ERN amplitudes were greatest for control children and smallest for EXT children with MIXED children in between, but only prior to the emotion induction. These results were paralleled by behavioral differences in response time and performance monitoring. ERP activity was localized to cortical sources suggestive of the dorsal anterior cingulate for control children, posterior cingulate areas for the EXT children, and both posterior cingulate and ventral cingulate/prefrontal regions for the MIXED children. These findings highlight different mechanisms of self-regulation underlying externalizing subtypes and point toward distinct developmental pathways and treatment strategies.We gratefully acknowledge the financial support provided by Grant 1 R21 MH67357-01 from the Developmental Psychopathology and Prevention Research branch of the National Institute of Mental Health (NIMH), as well as support from the Canadian Institutes for Health Research (CIHR). We are also grateful for support provided (to P.D.Z.) by the Canadian Foundation for Innovation.
Marginal Analysis of Incomplete Longitudinal Binary Data: A Cautionary Note on LOCF Imputation

Summary In recent years there has been considerable research devoted to the development of methods for the analysis of incomplete data in longitudinal studies. Despite these advances, the methods used in practice have changed relatively little, particularly in the reporting of pharmaceutical trials. In this setting, perhaps the most widely adopted strategy for dealing with incomplete longitudinal data is imputation by the “last observation carried forward” (LOCF) approach, in which values for missing responses are imputed using observations from the most recently completed assessment. We examine the asymptotic and empirical bias, the empirical type I error rate, and the empirical coverage probability associated with estimators and tests of treatment effect based on the LOCF imputation strategy. We consider a setting involving longitudinal binary data with longitudinal analyses based on generalized estimating equations, and an analysis based simply on the response at the end of the scheduled follow‐up. We find that for both of these approaches, imputation by LOCF can lead to substantial biases in estimators of treatment effects, the type I error rates of associated tests can be greatly inflated, and the coverage probability can be far from the nominal level. Alternative analyses based on all available data lead to estimators with comparatively small bias, and inverse probability weighted analyses yield consistent estimators subject to correct specification of the missing data process. We illustrate the differences between various methods of dealing with drop‐outs using data from a study of smoking behavior.
Improved Automatic Detection of New T2 Lesions in Multiple Sclerosis Using Deformation Fields

BACKGROUND AND PURPOSE: Detection of disease activity, defined as new/enlarging T2 lesions on brain MR imaging, has been proposed as a biomarker in MS. However, detection of new/enlarging T2 lesions can be hindered by several factors that can be overcome with image subtraction. The purpose of this study was to improve automated detection of new T2 lesions and reduce user interaction to eliminate inter- and intraobserver variability. MATERIALS AND METHODS: Multiparametric brain MR imaging was performed at 2 time points in 36 patients with new T2 lesions. Images were registered by using an affine transformation and the Demons algorithm to obtain a deformation field. After affine registration, images were subtracted and a threshold was applied to obtain a lesion mask, which was then refined by using the deformation field, intensity, and local information. This pipeline was compared with only applying a threshold, and with a state-of-the-art approach relying only on image intensities. To assess improvements, we compared the results of the different pipelines with the expert visual detection. RESULTS: The multichannel pipeline based on the deformation field obtained a detection Dice similarity coefficient close to 0.70, with a false-positive detection of 17.8% and a true-positive detection of 70.9%. A statistically significant correlation (r = 0.81, P value = 2.2688e-09) was found between visual detection and automated detection by using our approach. CONCLUSIONS: The deformation field–based approach proposed in this study for detecting new/enlarging T2 lesions resulted in significantly fewer false-positives while maintaining most true-positives and showed a good correlation with visual detection annotations. This approach could reduce user interaction and inter- and intraobserver variability.