Miracle-dz/UniFAR-FTUs huggingface dataset:
The SRT method: randomized strategies for exploration

We present a method for sensor-based exploration of unknown environments by a mobile robot. The method is based on the randomized incremental generation of a data structure called sensor-based random tree (SRT), which represents a roadmap of the explored area with an associated safe region. Different exploration strategies may be obtained by instantiating the general method with different perception techniques. Two such techniques are discussed: the first, conservative and particularly suited to noisy sensors, results in an exploration strategy called SRT-Ball. The second perception technique is more confident, and the corresponding strategy is called SRT-Star. The two strategies are critically compared by simulations as well as by experiments on the MagellanPro robot.
Long-term effects of rTMS on motor recovery in patients after subacute stroke.

OBJECTIVE Repetitive transcranial magnetic stimulation (rTMS) has been recognized as a promising intervention for treatment of stroke patients. However, most previous reports have described the short-term effects of rTMS on motor performance. We conducted a sham-controlled trial to evaluate long-term effects of high-frequency rTMS on motor recovery in subacute stroke patients. METHODS Twenty-eight patients were randomly divided into two groups, and received either real or control rTMS. Both treatments were accompanied by motor practice. A daily dose of 1000 pulses of subthreshold 10 Hz rTMS was applied over the primary motor cortex of the affected hemisphere for 10 days within one month after onset of stroke. Motor function was assessed before and after treatment, and 3 months after the stroke. RESULTS Motor function improved in both groups after treatment; however, patients who received real rTMS experienced additional improvement in motor function of the affected upper limb. Over 3 months after the stroke, the time and type of intervention for the Motoricity Index of the affected upper extremity showed significant interaction. CONCLUSION Positive long-term effects on motor recovery could be achieved after 10 daily sessions of high-frequency rTMS in conjunction with motor practice during the sub-acute period of stroke.
Regenerated Sciatic Nerve Axons Stimulated through a Chronically Implanted Macro-Sieve Electrode

Sieve electrodes provide a chronic interface for stimulating peripheral nerve axons. Yet, successful utilization requires robust axonal regeneration through the implanted electrode. The present study determined the effect of large transit zones in enhancing axonal regeneration and revealed an intimate neural interface with an implanted sieve electrode. Fabrication of the polyimide sieve electrodes employed sacrificial photolithography. The manufactured macro-sieve electrode (MSE) contained nine large transit zones with areas of ~0.285 mm2 surrounded by eight Pt-Ir metallized electrode sites. Prior to implantation, saline, or glial derived neurotropic factor (GDNF) was injected into nerve guidance silicone-conduits with or without a MSE. The MSE assembly or a nerve guidance conduit was implanted between transected ends of the sciatic nerve in adult male Lewis rats. At 3 months post-operation, fiber counts were similar through both implant types. Likewise, stimulation of nerves regenerated through a MSE or an open silicone conduit evoked comparable muscle forces. These results showed that nerve regeneration was comparable through MSE transit zones and an open conduit. GDNF had a minimal positive effect on the quality and morphology of fibers regenerating through the MSE; thus, the MSE may reduce reliance on GDNF to augment axonal regeneration. Selective stimulation of several individual muscles was achieved through monopolar stimulation of individual electrodes sites suggesting that the MSE might be an optimal platform for functional neuromuscular stimulation.
Study design and rationale for Optimal aNtiplatelet pharmacotherapy guided by bedSIDE genetic or functional TESTing in elective percutaneous coronary intervention patients (ONSIDE TEST): a prospective, open-label, randomised parallel-group multicentre trial (NCT01930773).

BACKGROUND AND AIM High platelet reactivity (HPR) and presence of CYP2C19 loss-of-function alleles are associated with higher risk for periprocedural myocardial infarction in clopidogrel-treated patients undergoing percutaneous coronary intervention (PCI). It is unknown whether personalised treatment based on platelet function testing or genotyping can prevent such complications. METHODS The ONSIDE-TEST is a multicentre, prospective, open-label, randomised controlled clinical trial aiming to assess if optimisation of antiplatelet therapy based on either phenotyping or genotyping is superior to conventional care. Patients will be randomised into phenotyping, genotyping, or control arms. In the phenotyping group, patients will be tested with the VerifyNow P2Y12 assay before PCI, and patients with a platelet reactivity unit greater than 208 will be switched over to prasugrel, while others will continue on clopidogrel therapy. In the genotyping group, carriers of the *2 loss-of-function allele will receive prasugrel for PCI, while wild-type subjects will be treated with clopidogrel. Patients in the control arm will be treated with standard-dose clopidogrel. The primary endpoint of the study is the prevalence of periprocedural myocardial injury within 24 h after PCI in the controls as compared to the phenotyping and genotyping group. Secondary endpoints include cardiac death, myocardial infarction, definite or probable stent thrombosis, or urgent repeat revascularisation within 30 days of PCI. Primary safety outcome is Bleeding Academic Research Consortium (BARC) type 3 and 5 bleeding during 30 days of PCI. SUMMARY The ONSIDE TEST trial is expected to verify the clinical utility of an individualised antiplatelet strategy in preventing periprocedural myocardial injury by either phenotyping or genotyping. TRIAL REGISTRATION ClinicalTrials.gov: NCT01930773.
Inclusion complexes of beta-cyclodextrin with tranquilizing drugs phenothiazines in aqueous solution.

The interaction of tranquilizing drugs phenothiazines with β-cyclodextrin in aqueous solution was studied by circular dichroism, ultraviolet (UV) absorption, and proton magnetic resonance spectroscopies. The induced circular dichroism bands and UV absorption changes were quantitatively investigated and stoichiometric ratio, which was found to be 1 : 1, and formation constants of inclusion complexes were obtained. In β-cyclodextrin-drug system, protons located in a cavity of β-cyclodextrin were found to be subjected to anisotropic shielding, while protons of phenyl and N-substituted groups in the drug shifted to low field, in which all peaks caused remarkable broadening. Formation constants were correlated well with partition coefficient of drug and also with the magnitude of proton magnetic resonance spectral broadening. These spectral changes strongly suggested that aromatic portion of drug was included into hydrophobic cavity of β-cyclodextrin, while N-substituents of drug interacted with the outside groups of β-cyclodextrin cavity.
The Effects of Substituents and Solvents on the Conformation of Benzophenones

Motivation. Natural and synthetic benzophenones are compounds of great scientific and applied interest due to the varied biological and physicochemical properties that they posses. As part of a program aimed at investigating new physicochemical properties of substituted benzophenones, we carry out a study on the influence of the substituents and solvents upon the molecular conformations of these compounds. In the future, we expect to propose relationships between the molecular structural parameters with diverse experimental properties of the compounds that are currently being determined in our laboratory. Method. The HF/6–31G(d) and B3LYP/6–31G(d) methods were used for calculations. Onsager’s and Tomasi’s models were used to analyze the solvent effects on the nine benzophenones studied. Results. A conformational equilibrium was proposed between the two conformers of benzophenones with the greatest thermodynamic stability. The total energies, torsional angles, dipole moments, structural and reactivity molecular parameters, and conformational equilibrium constants were calculated in vacuum, ethanol, methanol and water. The calculated magnitudes were correlated with Hammett’s substituent constants and parameters of solvating solvents. Conclusions. The benzophenones investigated have non–planar structures. Very good linear relationships between the molecular dihedral angles and Hammett’s p–substituent constants were obtained. Electron–donating substituents increase the planarity of the substituted benzoyl group that involves phenyl ring A of the molecules, as well as the folding of phenyl ring B. The conformational equilibrium constants of o–hydroxy–benzophenones ranged approximately between 10
Intravitreal Injection of the Attenuated Pseudorabies Virus PRV Bartha Results in Infection of the Hamster Suprachiasmatic Nucleus Only by Retrograde Transsynaptic Transport via Autonomic Circuits

Intravitreal injection of the attenuated strain of pseudorabies virus (PRV Bartha) results in transneuronal spread of virus to a restricted set of central nuclei in the rat and mouse. We examined the pattern of central infection in the golden hamster after intravitreal inoculation with a recombinant strain of PRV Bartha constructed to express enhanced green fluorescent protein (PRV 152). Neurons in a subset of retinorecipient nuclei [i.e., suprachiasmatic nucleus (SCN), intergeniculate leaflet, olivary pretectal nucleus (OPN), and lateral terminal nucleus] and autonomic nuclei [i.e., paraventricular hypothalamic nucleus and Edinger–Westphal nucleus (EW)] are labeled by late stages of infection. Infection of the EW precedes infection in retinorecipient structures, raising the possibility that the SCN becomes infected by retrograde transsynaptic infection via autonomic (i.e., EW) circuits. We tested this hypothesis in two ways: (1) by removing the infected eye 24 hr after PRV 152 inoculation, well before viral infection first appears in the SCN; and (2) by examining central infection after intravitreal PRV 152 injection in animals with ablation of the EW. The pattern and time course of central infection were unchanged after enucleation, whereas EW ablation before intravitreal inoculation eliminated viral infection in the SCN. The results of EW lesions along with known connections between EW, OPN, and SCN indicate that intravitreal injection of PRV Bartha produces a retrograde infection of the autonomic innervation of the eye, which subsequently labels a restricted set of retinorecipient nuclei via retrograde trans-synaptic infection. These results, taken together with other genetic data, indicate that the mutations in PRV Bartha render the virus incapable of anterograde transport. PRV Bartha is thus a retrograde transsynaptic marker in the CNS.
Comparison of Two Target Selection Methods for Two-Thumb Touchpad Typing

ABSTRACT As an option for remote text entry, the possibility of bimanual text entry was explored using a touchpad that is called two-thumb touchpad typing (4-T). The design of a 4-T interface presents a few important design options to examine, and one of them is a target selection method. In this study, two 4-T interfaces were designed, called SlideType and FlyType. These interfaces use two different target selection methods, slide-and-click and fly-and-touch, respectively, and their prototypes were implemented using an optical hover-tracking touchpad. An experiment with the prototypes showed that FlyType was faster than SlideType and could achieve a text entry speed over 24 words per minute after practicing 2 hr. In addition, a microanalysis of thumb movements during the experiment showed that there are clear quantitative differences between the two methods in the degree of ballisticity of finger motions, in the concurrency of the movements of the two thumbs, and in the degree of integration between reaching and selecting actions, and that FlyType supports a more integral, ballistic, and concurrent motor skill than SlideType.
An Eulerian path approach to DNA fragment assembly

For the last 20 years, fragment assembly in DNA sequencing followed the “overlap–layout–consensus” paradigm that is used in all currently available assembly tools. Although this approach proved useful in assembling clones, it faces difficulties in genomic shotgun assembly. We abandon the classical “overlap–layout–consensus” approach in favor of a new euler algorithm that, for the first time, resolves the 20-year-old “repeat problem” in fragment assembly. Our main result is the reduction of the fragment assembly to a variation of the classical Eulerian path problem that allows one to generate accurate solutions of large-scale sequencing problems. euler, in contrast to the celera assembler, does not mask such repeats but uses them instead as a powerful fragment assembly tool.
Can Resveratrol Treatment Control the Progression of Induced Periodontal Disease? A Systematic Review and Meta-Analysis of Preclinical Studies

Resveratrol is an anti-inflammatory compound found in several foods. Periodontal disease (PD) is associated to other systemic diseases, and inflammation may be responsible for the association. Consequently, controlling inflammation not only may benefit oral health but also may assist with the management of other chronic inflammatory conditions. We aimed to investigate the effects of resveratrol administration on PD control in preclinical studies. A systematic search was performed for scientific articles using both electronic databases and a manual search using combinations of the following keywords: “resveratrol” OR “3,5,4′-trihydroxystilbene” AND “periodontal disease” OR “periodontitis” OR “gingivitis”. Only in vivo original studies investigating resveratrol treatment on experimental animal models of PD were selected. A quality assessment of the studies was performed using the Animal Research Reporting In Vivo Experiment (ARRIVE) guidelines, and the risk of bias was assessed using the Syrcle tool. The search returned 570 articles, and 11 matched the inclusion criteria. A meta-analysis showed that resveratrol treatment attenuated alveolar bone loss (τ2 = 0.0041; 95% CI: −0.14; −0.04). The ARRIVE criteria reported a good quality of studies in general (mean score 28.5 ± 2.5). However, five Syrcle domains indicated a high risk of bias or did not present information clearly. We concluded that, in preclinical studies, resveratrol treatment prevented PD progression.
Photo Voltaic (PV) fed Three Phase Induction Motor Drive for Rural Pumping Applications based on Single Stage Power Conversion

This paper emphasizes on proposing a cost effective photovoltaic (PV) fed 3 phase Induction motor drive which serves for rural pumping applications. Generally in a standalone system, the solar panels generate direct current energy which is then stored in rechargeable batteries and the battery set up in turn will serve as a source for the inverter. But here in this proposed work a new single stage battery-less power conversion is employed by designing a maximum power point tracker (MPPT) embedded boost converter which revolutionizes the present tradition and makes the overall cost of the setup to go down considerably. The proposed work is realized as a prototype consisting PV array of 500watts, MPPT aided boost converter, three phase inverter and a three phase squirrel cage induction drive of 357 watts. An efficient and low cost micro controller dspic4011 is used as the platforms to code and implement the prominent perturb and observe MPPT technique. Sinusoidal pulse width modulation (SPWM) is the control technique employed for the three phase inverter. To validate the experimental results simulation of the whole set up is carried out in Matlab/Simulink environment. Simulation and hardware results reveal that the system is versatile.
On the Asymptotic Efficiency of Approximate Bayesian Computation Estimators

Many statistical applications involve models for which it is difficult to evaluate the likelihood, but from which it is relatively easy to sample. Approximate Bayesian computation is a likelihood-free method for implementing Bayesian inference in such cases. We present results on the asymptotic variance of estimators obtained using approximate Bayesian computation in a large-data limit. Our key assumption is that the data are summarized by a fixed-dimensional summary statistic that obeys a central limit theorem. We prove asymptotic normality of the mean of the approximate Bayesian computation posterior. This result also shows that, in terms of asymptotic variance, we should use a summary statistic that is the same dimension as the parameter vector, p; and that any summary statistic of higher dimension can be reduced, through a linear transformation, to dimension p in a way that can only reduce the asymptotic variance of the posterior mean. We look at how the Monte Carlo error of an importance sampling algorithm that samples from the approximate Bayesian computation posterior affects the accuracy of estimators. We give conditions on the importance sampling proposal distribution such that the variance of the estimator will be the same order as that of the maximum likelihood estimator based on the summary statistics used. This suggests an iterative importance sampling algorithm, which we evaluate empirically on a stochastic volatility model.
A Dynamic Quality-Adjustable H.264 Video Encoder for Power-Aware Video Applications

This paper proposes a dynamic quality-adjustable H.264 baseline profile (BP) video encoder that comprises 470 Kgates and 13.3 kB SRAM in a core size of 4.3 × 4.3 mm2 using TSMC 0.13 ¿m 1P8M CMOS technology. Exploiting parameterized algorithms for motion estimation and intra prediction, the proposed design can dynamically configure the encoding modes with the design trade-off between power consumption and video quality for various video encoding applications. In addition, the proposed basic unit (BU)-based rate control hardware can maintain a constant and stable bit rate for network video transmission. It achieves real-time H.264 video encoding on CIF, D1, and HD720@30 frames/s with 7 mW to 25 mW, 27 mW to 162 mW, and 122 mW to 183 mW power dissipation in different quality modes.
A Decentralized Model Predictive Control for Operation of Multiple Distributed Generators in an Islanded Mode

The increasing penetration of distributed and renewable generation presents power systems with a challenge of accommodating multiple inverter-based generators. Distributed generators (DGs), capable of operating in the islanded mode, are often installed in microgrids. However, a control system for operating multiple DGs in the islanded mode using voltage-sourced converters is a real challenge under uncertainties in load parameters, unbalanced phase conditions, and transients. This paper proposes a novel approach to decentralized control of multiple DGs. This approach is based on a combination of a voltage controller using model predictive control and a fast current controller using a discrete-time sliding-mode controller for limiting the inverter currents under overload conditions. Performance of the proposed control system is compared with a robust servomechanism program controller. The proposed control strategy provides fast tracking, robustness, and fast transient recovery in voltage and current under: 1) short-circuit conditions; 2) load transients; and 3) unbalanced loads. Various scenarios including reference signal tracking and robustness against the load perturbations are considered. Results are presented and discussed.
Working Paper No . 443 Personality and Earnings By

This paper studies personality as a potential explanation for wage differentials between apparently similar workers. This follows initial studies by Jencks (1979) that suggest that certain personality traits, such as industriousness and leadership, have an impact on earnings. The paper aims to provide a theoretical framework within which these effects may be analyzed. The study begins by outlining four issues as a backdrop to the model: rationality, the industry, firms, and workers. A crucial factor to the model is the meme—a mental gene that affects personality. Taking these four factors into consideration, the Contested Exchange model from Bowles and Gintis (1990) is used. Then, it is adapted to study memetic effects on the wage rate. This is followed by an analysis of how memes may affect personality and thus earnings. The issues that require further study and resolution are 1) which traits create wage ifferentials, and 2) two-way causality: does personality affect the wage, or does a wage premium become an incentive for a person to adopt new memes?
Protein-mediated protection as the predominant mechanism for defining processed mRNA termini in land plant chloroplasts

Most chloroplast mRNAs are processed from larger precursors. Several mechanisms have been proposed to mediate these processing events, including site-specific cleavage and the stalling of exonucleases by RNA structures. A protein barrier mechanism was proposed based on analysis of the pentatricopeptide repeat (PPR) protein PPR10: PPR10 binds two intercistronic regions and impedes 5′- and 3′-exonucleases, resulting in processed RNAs with PPR10 bound at the 5′- or 3′-end. In this study, we provide evidence that protein barriers are the predominant means for defining processed mRNA termini in chloroplasts. First, we map additional RNA termini whose arrangement suggests biogenesis via a PPR10-like mechanism. Second, we show that the PPR protein HCF152 binds to the immediate 5′- or 3′-termini of transcripts that require HCF152 for their accumulation, providing evidence that HCF152 defines RNA termini by blocking exonucleases. Finally, we build on the observation that the PPR10 and HCF152 binding sites accumulate as small chloroplast RNAs to infer binding sites of other PPR proteins. We show that most processed mRNA termini are represented by small RNAs whose sequences are highly conserved. We suggest that each such small RNA is the footprint of a PPR-like protein that protects the adjacent RNA from degradation.
How Evolutionary Visual Software Analytics Supports Knowledge Discovery

Evolutionary visual software analytics is a specialization of visual analytics. It is aimed at supporting software maintenance processes by aiding the understanding and comprehension of software evolution with the active participation of users. Therefore, it deals with the analysis of software projects that have been under development and maintenance for several years and which are usually formed by thousands of software artifacts, which are also associated to logs from communications, defect-tracking and software configuration management systems. Accordingly, evolutionary visual software analytics aims to assist software developers and software project managers by means of an integral approach that takes into account knowledge extraction techniques as well as visual representations that make use of interaction techniques and linked views. Consequently, this paper discusses the implementation of an architecture based on the evolutionary visual software analytics process and how it supports knowledge discovery during software maintenance tasks.