Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of radiation dose on concurrent chemoradiotherapy for limited-stage small-cell lung cancer

Purpose To evaluate clinical outcomes according to radiation dose in patients with limited-stage small-cell lung cancer (LS-SCLC) treated with concurrent chemoradiotherapy (CCRT). Materials and Methods From January 2006 to December 2015, 38 patients with LS-SCLC were treated with CCRT with etoposide and cisplatin. Total radiation doses ranged from 45 Gy to 66 Gy (1.8–2 Gy/fraction) and were classified into three groups: 45–54 Gy, 60–63 Gy, and 66 Gy. The impact of radiation dose on survival outcomes were evaluated. Toxicities were evaluated according to the Common Terminology Criteria for Adverse Events version 4.03. Results The median follow-up period was 21 months. The 2-year overall survival (OS) and local failure-free survival (LFFS) rates were 45.8% and 67.5%, respectively. The 2-year LFFS rates were 33.3% for 45–54 Gy group, 68.6% for 60–63 Gy group, and 87.1% for 66 Gy group (p = 0.014). In multivariate analysis, radiation dose was a significant factor for LFFS (p = 0.015). Although radiation dose was not a significant factor for OS and disease-free survival (DFS) in multivariate analysis, both OS and DFS of 66 Gy group tended to be better than that of 45–63 Gy group in univariate analysis. However, there were no differences in severe toxicities among three groups. Conclusion Higher radiation dose achieved better local control in patients with LS-SCLC treated with CCRT. In addition, a total dose of 66 Gy tended to improve OS and DFS.
Multi-tap analog self-interference cancellation for full-duplex communications

A single antenna multi-tap (MT) canceller is considered for full-duplex (FD) communications, where the tap coefficients are obtained from the estimated self-interference (SI) channel state information (CSI). The estimated SI channel suffers from the radio frequency (RF) impairment imperfections of the transmit and receive RF chains, which should be calibrated to obtain more accurate CSI. Then, the residual SI power with RF impairment imperfections calibrated and uncalibrated after the MT cancellation are calculated respectively. Considering the dynamic range of the analog-to-digital converter and the linearity of the receiver chain, the achievable capacity of FD transceivers is derived as a function of the residual SI power after MT cancellation. Furthermore, the simulation results demonstrate that the RF impairment coefficients and the tap delay alignment error, i.e., the error between the corresponding tap delay of the canceller and that of the SI channel, reduce the cancellation ability and bring rate gain loss over half-duplex transceivers.
Big Five Personality Stability, Change, and Codevelopment Across Adolescence and Early Adulthood

Using data from 2 large and overlapping cohorts of Dutch adolescents, containing up to 7 waves of longitudinal data each (N = 2,230), the present study examined Big Five personality trait stability, change, and codevelopment in friendship and sibling dyads from age 12 to 22. Four findings stand out. First, the 1-year rank-order stability of personality traits was already substantial at age 12, increased strongly from early through middle adolescence, and remained rather stable during late adolescence and early adulthood. Second, we found linear mean-level increases in girls’ conscientiousness, in both genders’ agreeableness, and in boys’ openness. We also found temporal dips (i.e., U-shaped mean-level change) in boys’ conscientiousness and in girls’ emotional stability and extraversion. We did not find a mean-level change in boys’ emotional stability and extraversion, and we found an increase followed by a decrease in girls’ openness. Third, adolescents showed substantial individual differences in the degree and direction of personality trait changes, especially with respect to conscientiousness, extraversion, and emotional stability. Fourth, we found no evidence for personality trait convergence, for correlated change, or for time-lagged partner effects in dyadic friendship and sibling relationships. This lack of evidence for dyadic codevelopment suggests that adolescent friends and siblings tend to change independently from each other and that their shared experiences do not have uniform influences on their personality traits.
Cosimulation of Intelligent Power Systems: Fundamentals, Software Architecture, Numerics, and Coupling

Smart grids link various types of energy technologies-such as power electronics, machines, grids, and markets-via communication technology, which leads to a transdisciplinary, multidomain system. Simulation packages for assessing system integration of components typically cover only one subdomain, while simplifying the others. Cosimulation overcomes this by coupling subdomain models that are described and solved within their native environments, using specialized solvers and validated libraries. This article discusses the state of the art and conceptually describes the main challenges for simulating intelligent power systems. This article, part 1 of 2 on this subject, covers fundamental concepts. Part 2 will appear in a future issue of IEEE Electrification Magazine and cover applications.
Limitations in ROP Programs in 32 Neonatal Intensive Care Units in Five States in Mexico

Retinopathy of prematurity (ROP) is the main cause of avoidable blindness in children in Mexico despite National ROP Guidelines and examination of preterm infants being a legal requirement. Objective. To assess coverage of ROP programs and their compliance with national guidelines. Study Design. Thirty-two neonatal intensive care units (NICUs) in five of the largest states were visited. Staff were interviewed to collect information on their ROP programs which were defined as (1) compliant, if National Guidelines for screening and treatment were followed, (2) noncompliant, if other approaches were used, or (3) no program. Results. Only 10 (31.2%) had fully compliant programs and 11 (34.4%) had no program. In the remaining 11 (34.4%) different screening criteria were used (7 units): screening was undertaken by an ophthalmologist in unsalaried time (4), was not undertaken in the NICU (2), and was undertaken by a neonatologist (1) and/or Avastin was used as first-line treatment (7). Poorer states had poorer programs. Conclusions. Despite legislation mandating eye examination of preterm births, many ROP programs in the largest cities in Mexico require improvement or need to be established. Prevention of blindness due to ROP needs to be prioritized in Mexico to control the epidemic of ROP blindness.
Multi-path mmWave cooperative communications for delivering multimedia resources

With the explosive growth of mobile traffic, especially the multimedia traffic, the fifth-generation (5G) wireless networks are expected to not only reduce delay effectively but also increase the network throughput significantly, while guaranteeing the quality of service (QoS) for wireless multimedia traffics. Based on the millimeter wave (mmWave) multi-hop relay technology, latency, network throughput and energy efficiency are analyzed in 5G network scenarios for delivering multimedia resources in this paper. Furthermore, the multi-path mmWave cooperative communication (MMCC) scheme is developed to facilitate the multimedia resources delivering in 5G heterogeneous networks. Simulation results indicate that a higher network throughput is achieved by adopting the proposed MMCC scheme, compared with the existing conventional single-hop sub-6 GHz communication scheme.
On the Effectiveness of Sensor-enhanced Keystroke Dynamics Against Statistical Attacks

In recent years, simple password-based authentication systems have increasingly proven ineffective for many classes of real-world devices. As a result, many researchers have concentrated their efforts on the design of new biometric authentication systems. This trend has been further accelerated by the advent of mobile devices, which offer numerous sensors and capabilities to implement a variety of mobile biometric authentication systems. Along with the advances in biometric authentication, however, attacks have also become much more sophisticated and many biometric techniques have ultimately proven inadequate in face of advanced attackers in practice. In this paper, we investigate the effectiveness of sensor-enhanced keystroke dynamics, a recent mobile biometric authentication mechanism that combines a particularly rich set of features. In our analysis, we consider different types of attacks, with a focus on advanced attacks that draw from general population statistics. Such attacks have already been proven effective in drastically reducing the accuracy of many state-of-the-art biometric authentication systems. We implemented a statistical attack against sensor-enhanced keystroke dynamics and evaluated its impact on detection accuracy. On one hand, our results show that sensor-enhanced keystroke dynamics are generally robust against statistical attacks with a marginal equal-error rate impact (<0.14%). On the other hand, our results show that, surprisingly, keystroke timing features non-trivially weaken the security guarantees provided by sensor features alone. Our findings suggest that sensor dynamics may be a stronger biometric authentication mechanism against recently proposed practical attacks.
Learning to Rank : Using Bayesian Networks

Ranking is one of the key components of an Information Retrieval system. Recently supervised learning is involved for learning the ranking function and is called ’Learning to Rank’ collectively. In this study we present one approach to solve this problem. We intend to test this problem in different stochastic environment and hence we choose to use Bayesian Networks for machine learning. This work also involves experimentation results on standard learning to rank dataset ’Letor4.0’[6]. We call our approach as BayesNetRank. We compare the performance of BayesNetRank with another Support Vector Machine(SVM) based approach called RankSVM [5]. Performance analysis is also involved in the study to identify for which kind of queries, proposed system gives results on either extremes. Evaluation results are shown using two rank based evaluation metrics, Mean Average Precision (MAP) and Normalized Discounted Cumulative Gain (NDCG).
CELL VIABILITY AND DNA DAMAGE IN MRC 5 AND HeLa CELL LINES AFTER HISTONE H 1 KNOCKOUT BY CRISPR-Cas 9 GENOME EDITING TECHNOLOGY

Chromatin research mainly focused on the core histones, whereas the role of H1.5 linker histone is poorly understood. Today CRISPR-Cas9 (clustered, regularly interspaced, short palindromic repeats associated protein 9) genome editing technology provides an opportunity to analyze functions of different genes introducing targeted loss-of function mutations. Here we demonstrate the role of histone H 1.5 in cell viability and genome integrity in HeLa and MRC5 cells using trypan blue exclusion test and single-cell gel electrophoresis (comet) assay.
Lines of malicious code: insights into the malicious software industry

Malicious software installed on infected computers is a fundamental component of online crime. Malware development thus plays an essential role in the underground economy of cyber-crime. Malware authors regularly update their software to defeat defenses or to support new or improved criminal business models. A large body of research has focused on detecting malware, defending against it and identifying its functionality. In addition to these goals, however, the analysis of malware can provide a glimpse into the software development industry that develops malicious code. In this work, we present techniques to observe the evolution of a malware family over time. First, we develop techniques to compare versions of malicious code and quantify their differences. Furthermore, we use behavior observed from dynamic analysis to assign semantics to binary code and to identify functional components within a malware binary. By combining these techniques, we are able to monitor the evolution of a malware's functional components. We implement these techniques in a system we call Beagle, and apply it to the observation of 16 malware strains over several months. The results of these experiments provide insight into the effort involved in updating malware code, and show that Beagle can identify changes to individual malware components.
How hospital survey teams function

Purpose The purpose of this paper is to understand how inspection team members work together to conduct surveys of hospitals, the challenges teams may face and how these might be addressed. Design/methodology/approach Data were gathered through an evaluation of a new regulatory model for acute hospitals in England, implemented by the Care Quality Commission (CQC) during 2013-2014. The authors interviewed key stakeholders, observed inspections and surveyed and interviewed inspection team members and hospital staff. Common characteristics of temporary teams provided an analytical framework. Findings The temporary nature of the inspection teams hindered the conduct of some inspection activities, despite the presence of organisational citizenship behaviours. In a minority of sub-teams, there were tensions between CQC employed inspectors, healthcare professionals, lay people and CQC data analysts. Membership changes were infrequent and did not appear to inhibit team functioning, with members displaying high commitment. Although there were leadership authority ambiguities, these were not problematic. Existing processes of recruitment and selection, training and preparation and to some extent leadership, did not particularly lend themselves to addressing the challenges arising from the temporary nature of the teams. Research limitations/implications Conducting the research during the piloting of the new regulatory approach may have accentuated some challenges. There is scope for further research on inspection team leadership. Practical implications Issues may arise if inspection and accreditation agencies deploy temporary, heterogeneous survey teams. Originality/value This research is the first to illuminate the functioning of inspection survey teams by applying a temporary teams perspective.
Compact Dual-Wideband Bandpass Filter Using a Novel Multiple-Mode Resonator

─ This paper presents a novel dualwideband bandpass filter (BPF) structure, which consists of a two-end shorted stepped-impedance resonator with two pairs of non-identical steppedimpedance open stubs (SIOSs) and a uniformimpedance open stub (UIOS) symmetrically loaded on its high impedance section. The designed BPF has a directly coupled configuration, which can also introduce transmission zero (TZ) for filter design. The loaded SIOSs and UIOS not only excite multiple resonant modes but also introduce multiple TZs. After carefully arranging these resonant modes and TZs, the TZs can divide multiple resonant modes into multiple useful groups, which can be utilized to exploit two wideband passbands. The TZs between two passbands can improve passband selectivity and the band-toband isolation. As an example, a dual-wideband BPF centered at 1.57 / 5.59 GHz with -3 dB fractional bandwidth of 53% by 16% is designed and fabricated. The fabricated filter has a compact size of 0. 16λg × 0. 106λg. The measured results also exhibit a low insertion loss, good return loss and wide stopband. Index Terms Bandpass filter (BPF), dual-band, multiplemode resonator (MMR), and steppedimpedance resonator (SIR).
Dual Effect of Curcumin/BMP-2 Loaded in HA/PLL Hydrogels on Osteogenesis In Vitro and In Vivo.

In the present study, we evaluated the potential of poly-l-lysine/hyaluronic acid (HA/PLL) hydrogels containing curcumin (CUR) and bone morphogenetic protein-2 (BMP-2) as bone tissue regeneration scaffolds. Hydrogels HP-1˜2 were formed by amide bonds via the condensation reactions between 0.02 μmol HA and 0.06–0.12 μmol poly-l-lysine · hydrobromide (PLL · HBr). Physical, chemical, and thermal analyses revealed that the amount of PLL · HBr significantly influenced hydrogel properties. Based on an In Vitro MG-63 cell proliferation test, HP-1˜2 were cytocompatible, and all hydrogels containing different amounts of CUR and BMP-2, except for HA0.02/PLL0.06/CUR20/BMP-2100 (HPCB-4), resulted in cell proliferation above 80%. An In Vitro release test showed that CUR and BMP-2 were consistently released from HA0.02/PLL0.06/CUR15 (HPC), HA0.02/PLL0.06/BMP-2100 (HPB), HA0.02/PLL0.06/CUR15/BMP-210 , 50 , or 100 (HPCB-1˜3), and HA0.02/PLL0.06/CUR10 or 20/BMP-2100 (HPCB-4˜5) for 7 and 28 days, respectively. In Vitro ALP activity and calcium deposition and In Vivo micro-computed tomography (micro-CT) tests demonstrated the potential application of HPCB-3 as bone tissue regeneration scaffolds, suggesting that bone tissue regeneration can be optimized by controlling the amounts of CUR and BMP-2.
Traffic Analytics With Low-Frame-Rate Videos

In this paper, we investigate the possibility of monitoring highway traffic based on videos whose frame rate is too low to accurately estimate motion features. The goal of the proposed method is to <italic>recognize</italic> traffic conditions instead of <italic>measuring</italic> them, as is usually the case. The main advantage of our approach comes from its ability to process low-frame-rate videos for which motion features cannot be estimated. Our method takes advantage of the highly redundant nature of traffic scenes that are pictured from a top-down perspective showing vehicles on a predominant asphalted road surrounded by background objects. Due to the limited variety of objects pictured in traffic scenes, our method gets to learn features that are specific to such images. With these features, our method is able to segment traffic images, classify traffic scenes, and estimate traffic density without requiring motion features. Different convolutional neural network models are proposed to segment traffic images in three different classes (<italic>Road</italic>, <italic>Car</italic>, and <italic>Background</italic>), classify traffic images into different categories (<italic>Empty</italic>, <italic>Fluid</italic>, <italic>Heavy</italic>, and <italic>Jam</italic>), and predict traffic density. We also propose a procedure to perform transfer learning of any of these models to new traffic scenes.
THE PARTICIPATION DIVIDE: Content creation and sharing in the digital age1

This paper looks at the prevalence of creative activity and sharing in an age when the barriers to disseminating material have been considerably lowered compared with earlier times. The authors use unique data to explore the extent to which young adults create video, music, writing and artistic photography, as well as the prevalence of sharing such material online. Findings suggest that despite new opportunities to engage in such distribution of content, relatively few people are taking advantage of these recent developments. Moreover, neither creation nor sharing is randomly distributed among a diverse group of young adults. Consistent with existing literature, creative activity is related to a person's socioeconomic status as measured by parental schooling. The novel act of sharing online, however, is considerably different by gender with men much more likely to engage in it. However, once internet user skill is controlled for, men and women are equally likely to post their materials on the Web.
A search log mining based query expansion technique to improve effectiveness in code search

The effectiveness of a code search engine is reduced when query terms do not represent the information needs properly or terms are ambiguous. As a result, many irrelevant code snippets and software artifacts are retrieved that hinder the developers reusing existing source code. In this paper, a technique named QExpandator is proposed that improves the effectiveness in code search by expanding query terms with search topic and content specific keywords. It extracts user queries and clicked code fragments from the previous search history and represents each query in a vector document. Jaccard similarity score is calculated for each term in the document vector and a posting list of conceptually similar words is created based on the similarity score. Finally, to expand a user query, top scored terms are retrieved for each query term and appended to the original query. To evaluate the technique, 22 user queries were selected and an existing approach was employed. QExpandator shows 48.6% more effectiveness in terms of precision at 10 (P@10) than the existing one. Moreover, for each query, it increases P@10 from 60.9% to 90% on an average due to using search topic and context specific keywords.
Retrospective Study of Histomoniasis (Blackhead) in California Turkey Flocks, 2000–2014

SUMMARY The flagellate parasite Histomonas meleagridis causes a severe disease in turkeys. Since nitarsone, the last antiflagellate feed additive, was withdrawn from the market, H. meleagridis has gained increasing clinical and economic importance, and frequently entire turkey flocks are lost to the disease. Even before the antiflagellate market withdrawal, H. meleagridis has been recognized as a noteworthy disease in commercial turkeys. The aim of this study was to compile and analyze data on histomoniasis outbreaks diagnosed by the California Animal Health and Food Safety System in the years 2000 through 2014 while nitarsone was still available. Sixty-two cases were included in the study. In all cases, the parasite was detected by histopathology. Five cases were from breeder flocks, 44 from commercial meat turkey flocks, and 13 from other flocks such as backyard flocks or pet turkeys. There were between one and eight cases each year with no clear trend over time. Most cases occurred in the warmer months between April and October with a clear peak in August. Turkeys in the flocks with the disease were aged between 2 wk and 15 mo, with a median age of 9 wk. In cases for which mortality was reported, daily mortality ranged between 0.04% and 2% with an average of 0.34% and a median of 0.15%. Five-week mortality in infected houses on three infected ranches was between 1.3% and 68%. In 12 cases, the parasite was observed in organs other than ceca and liver. These included spleen, kidney, bursa of Fabricius, proventriculus, lung, pancreas, and crop. In 58 cases, histomoniasis was considered the most significant and primary diagnosis; in four cases histomoniasis was regarded as an incidental finding. In 14 other outbreaks, detailed information was available. In 11 cases, more than one house on the ranch was affected; in five cases the disease spread to all houses. Total mortality in turkeys from affected flocks ranged between 12% and 65%. In eight flocks, the birds were marketed with a weight that was considered too light. In conclusion, the present study shows that even with nitarsone available as antiflagellate feed, additive histomoniasis was a serious disease of turkeys in the United States with an epidemiology similar to that observed in Europe.