Miracle-dz/UniFAR-FTUs huggingface dataset:
The complete mitochondrial genome of the flesh fly, Parasarcophaga portschinskyi (Diptera: Sarcophagidae)

Abstract The complete mitochondrial genome of Parasarcophaga portschinskyi (Diptera: Sarcophagidae), a forensically important entomology was sequenced for the first time. The 14,929 bp circular genome contains the 37 genes found in a typical Metazoan genome: 13 protein-coding genes, 2 ribosomal RNA genes and 22 transfer RNA genes. It also contains one non-coding A + T-rich region. All the protein initiation codons are ATN, except for cox1 that begins with TCG. Each of the base composition on heavy strand was as follows A: 38.94%, G: 9.69%, C: 14.13%, T: 37.24% and the A + T content 76.18%. The mitochondrial genome of Parasarcophaga portschinskyi presented will be valuable for resolving phylogenetic relationships within the family Sarcophagidae and order Diptera, and could be used to identify favorable genetic markers for species identifications for forensic purposes.
Lipopolysaccharide—cell interaction and induced cellular activation in whole blood of septic patients

We used biotinylatedLPS (LPSb) and flow cytometry to study LPS—monocyte interaction and LPS-induced cellular activation in whole blood from septic patients (SP). Expression of surface activation markers was evaluated on monocytes (HLA-DR) and T lymphocytes (CD69 and CD95), and intracellular TNF-α on monocytes. Saturating curve and kinetics of LPSb detection on monocytes were similar in SP and healthy volunteers (HV). LPSb bound to monocytes was detected after 5 min of incubation in both groups, with a more pronounced decay in SP. Monocytes from SP had a lower expression of HLA-DR as compared to HV, both constitutive and upon LPS stimulation. The proportion of monocytes producing TNF-α after LPS stimulus was higher in HV than SP (mean ± SD = 25.2 ± 14.2% and 2.2 ± 2.6%, respectively, P < 0.001). LPS-induced CD69 on T CD8+ and CD8— lymphocytes was similar for patients and controls. Expression of CD95 on T lymphocytes was higher in SP as compared to HV on T CD8+ cells (GMFI, mean ± SD = 22.3 ± 14.6 and 8.6 ± 5.0, respectively, P = 0.01) and CD8— cells (GMFI, mean ± SD = 28.3 ± 7.7 and 14 ± 4.3 respectively, P < 0.001). Thus, monocytes and lymphocytes seem to respond differently to LPS in septic patients. Monocyte hyporesponsiveness appears not to be related to a decreased binding capacity of LPS, but rather to an impaired signal transduction.
Dynamics of early postischemic myocardial functional recovery. Evidence of reperfusion-induced injury?

BACKGROUND The present study was designed to explore the relation between the duration of ischemia and the rate and extent of myocardial functional recovery after reperfusion. METHODS AND RESULTS Isolated rat hearts were perfused with blood from a support animal for 15 minutes (flow rate, 2.5 mL/min; perfusion pressure, 60.1 +/- 1.3 mm Hg). Control left ventricular developed pressure (LVDP) was measured, and the hearts (six per group) were subjected to 10, 20, 30, 40, 50, 60, 70, or 80 minutes of global ischemia (37 degrees C) and 60 minutes of reperfusion. Pacing (320 beats per minute) was instituted before and after ischemia. In all groups, transient arrhythmias occurred at the onset of reperfusion, to be followed by an early phase of recovery that peaked after 2 to 3 minutes of reperfusion. The relation between the extent of this initial recovery and the duration of preceding ischemia was described by a bell-shaped curve. Thus, the maximum initial mean recovery after 10, 20, 30, 40, 50, 60, 70, or 80 minutes of ischemia was 97%, 108%, 145%, 154%, 118%, 34%, 41%, and 24%, respectively, of preischemic LVDP. Possibly indicative of reperfusion-induced injury, LVDP then declined in all groups so that after 20 minutes of reperfusion, the mean recovery was 63%, 53%, 48%, 50%, 56%, 12%, 9%, and 5%, respectively. In the 10-, 20-, 30-, and 40-minute ischemia groups, there then was a secondary increase in LVDP, possibly indicating the start of recovery from stunning. After 60 minutes of reperfusion, the mean recovery of LVDP was 82%, 65%, 59%, 54%, 47%, 9%, 7%, and 4%, respectively; this second phase of recovery was inversely proportional to the duration of ischemia. To define the early phase of recovery that had been obscured by reperfusion-induced arrhythmias, we repeated the experiments with the inclusion of a cardioplegic infusion (St Thomas' solution for 2 minutes before ischemia). This significantly reduced the incidence of ventricular fibrillation during early reperfusion. The extent of the initial postischemic recovery of LVDP was similar to that observed without cardioplegia; however, the mean secondary recovery was greater in all groups. Again, the relation of early transient (2 to 5 minutes) recovery to the duration of ischemia was represented by a bell-shaped curve, whereas the secondary recovery was inversely related. CONCLUSIONS Although the results of the present study confirm the protective properties of cardioplegia, they also shed some light on the nature of reperfusion-induced injury and myocardial stunning and their complex relation to the severity of the preceding ischemia.
Knowledge sharing in Thai SMEs in manufacturing sector

The establishment of the AEC in 2015 is expanded market, increase opportunity for SMEs, however, the market is more competitive in ASEAN. Nowadays, SMEs play significant roles in country economic. In order to survive during the transition period, SMEs need the correct supporting tools to improve their productivity and efficiency. Globally, the adoption of KM in SMEs is becoming widespread. Despite, a large number of studies on KM, only a few studies focus on SMEs especially in Thailand. Knowledge sharing is a key step in KM approach. Therefore, the aim of this study is to identify the current practice of Knowledge Sharing in Thai SMEs within the manufacturing sector. Questionnaires were distributed to SMEs in Thailand, via online and paper based version. The total numbers of responses were 311 respondents from 20 Thai SMEs in manufacturing sector. Overall, the result shown is the biggest cultural and practical barrier sharing is Knowledge sharing is an extra workload and lack of time, respectively.
Do Lower-Body Dimensions and Body Composition Explain Vertical Jump Ability?

Abstract Caia, J, Weiss, LW, Chiu, LZF, Schilling, BK, Paquette, MR, and Relyea, GE. Do lower-body dimensions and body composition explain vertical jump ability? J Strength Cond Res 30(11): 3073–3083, 2016—Vertical jump (VJ) capability is integral to the level of success attained by individuals participating in numerous sport and physical activities. Knowledge of factors related to jump performance may help with talent identification and/or optimizing training prescription. Although myriad variables are likely related to VJ, this study focused on determining if various lower-body dimensions and/or body composition would explain some of the variability in performance. Selected anthropometric dimensions were obtained from 50 university students (25 men and 25 women) on 2 occasions separated by 48 or 72 hours. Estimated body fat percentage (BF%), height, body weight, hip width, pelvic width, bilateral quadriceps angle (Q-angle), and bilateral longitudinal dimensions of the feet, leg, thigh, and lower limb were obtained. Additionally, participants completed countermovement VJs. Analysis showed BF% to have the highest correlation with countermovement VJ displacement (r = –0.76, p < 0.001). When examining lower-body dimensions, right-side Q-angle displayed the strongest association with countermovement VJ displacement (r = –0.58, p < 0.001). Regression analysis revealed that 2 different pairs of variables accounted for the greatest variation (66%) in VJ: (a) BF% and sex and (b) BF% and body weight. Regression models involving BF% and lower-body dimensions explained up to 61% of the variance observed in VJ. Although the variance explained by BF% may be increased by using several lower-body dimensions, either sex identification or body weight explains comparatively more. Therefore, these data suggest that the lower-body dimensions measured herein have limited utility in explaining VJ performance.
An Online Temperature Measurement System Based Wireless Communication Technology

This paper describes an online temperature measurement system using wireless communication technology. The system is used in a temperature monitor of high-voltage equipments. A low power-consumption CPU and a precise thermo- resistance constitute the circuit of temperature measurement device, which can accurately measure temperature of equipments. To the indoor equipments, the real-time temperature datum sampled by the temperature measurement device is sent to receiver with infrared communication, and to the outdoor, with RF wireless communication. The scheme is a guarantee the security to isolate between high voltage side and low voltage side. And the devices are a part of an online temperature monitor system. This system has been putting into practice operation.
[Prevalence of malnutrition in the elderly Spanish population].

BACKGROUND Malnutrition in elderly has become an important problem of health, and is associated with an increase of morbidity and mortality in this age group. The aim of this study was to determine the prevalence of malnutrition in the Spanish institutionalized and living home elderly people. SUBJECTS AND METHOD A sample of 3,460 representative Spanish subjects older than 65 years old were studied (response rate of 96%). Nutritional status was gathered by Mini Nutritional Assessment questionnaire. RESULTS The prevalence of malnutrition was 3,3% among elderly living at home and 7,7% among institutionalized people. Malnutrition was more prevalent in women and people with a lower income. Increase of malnutrition with age was observed. CONCLUSIONS The observed prevalence of malnutrition in Spanish non-institutionalized elderly people was similar to observed in another populations. Sex, age and income were associated with a risk of malnutrition
Bidirectional Coupling between Ryanodine Receptors and Ca2+ Release-activated Ca2+ (CRAC) Channel Machinery Sustains Store-operated Ca2+ Entry in Human T Lymphocytes

Background: Ryanodine receptors (RyR) are intracellular Ca2+ release channels. Results: RyR are expressed in human T cells. Modulating the RyR activity in human T cells affects Ca2+ leakage from the store and store-operated Ca2+ entry. Conclusion: RyR strongly regulate Ca2+ influx in human T cells. Significance: RyR can be used as a target for manipulating immune responses in humans. The expression and functional significance of ryanodine receptors (RyR) were investigated in resting and activated primary human T cells. RyR1, RyR2, and RyR3 transcripts were detected in human T cells. RyR1/2 transcript levels increased, whereas those of RyR3 decreased after T cell activation. RyR1/2 protein immunoreactivity was detected in activated but not in resting T cells. The RyR agonist caffeine evoked Ca2+ release from the intracellular store in activated T cells but not in resting T cells, indicating that RyR are functionally up-regulated in activated T cells compared with resting T cells. In the presence of store-operated Ca2+ entry (SOCE) via plasmalemmal Ca2+ release-activated Ca2+ (CRAC) channels, RyR blockers reduced the Ca2+ leak from the endoplasmic reticulum (ER) and the magnitude of SOCE, suggesting that a positive feedback relationship exists between RyR and CRAC channels. Overexpression of fluorescently tagged RyR2 and stromal interaction molecule 1 (STIM1), an ER Ca2+ sensor gating CRAC channels, in HEK293 cells revealed that RyR are co-localized with STIM1 in the puncta formed after store depletion. These data indicate that in primary human T cells, the RyR are coupled to CRAC channel machinery such that SOCE activates RyR via a Ca2+-induced Ca2+ release mechanism, which in turn reduces the Ca2+ concentration within the ER lumen in the vicinity of STIM1, thus facilitating SOCE by reducing store-dependent CRAC channel inactivation. Treatment with RyR blockers suppressed activated T cell expansion, demonstrating the functional importance of RyR in T cells.
The glomerular filterability of insulin and of different molecular weight preparations of polyethylene glycol in the rabbit.

Jorgensen, K. E. , J. V. Mollerand M. I. Sheikh. The glomerular filterability of inulin and of different molecular weight preparations of polyethylene glycol in the rabbit. Acta physiol. scand. 1972. 84. 408–414. It has been claimed on the basis of clearance experiments that inulin is incompletely filterable through the glomerular membrane of the rat kidney (Berglund 1964, 1965). In the present study the renal excretion in the rabbit of inulin and different preparations of polyethylene glycol has been compared during constant infusion of these substances. Identical clearance values were obtained for inulin and polyethylene glycol, having molecular weights of 1500 (PEG–1500) and 4000 (PEG–4000). The ratio of the clearances between polyethylene glycol of a molecular weight of 6000 (PEG–6000) and inulin was smaller than unity (0.89±0.03). Gel filtration analysis of plasma and urine samples indicated unrestricted filtration of inulin through the glomerular membrane of this species. Furthermore, gel filtration and ultrafiltration experiments indicated that the molecular size of inulin and PEG–1500 is similar, while the molecular dimensions of PEG–6000 exceed that of the most high molecular weight fractions of inulin. It is concluded that the clearance of inulin, PEG–1500, and PEG–4000 may be used as a measure of the glomerular filtration rate in the rabbit, whereas the glomerular filtration of PEG–6000 is restricted to some extent. The incomplete filterability of PEG–6000 is attributed to the relatively larger molecular size.
Frequency Invariant Uniform Concentric Circular Arrays with Directional Elements

A new approach for designing frequency invariant (FI) uniform concentric circular arrays (UCCAs) with directional elements is proposed, and their applications to direction-of-arrival (DOA) estimation and adaptive beamforming are studied. By treating the sensors along the radial direction of the UCCA as linear subarrays and using appropriately designed beamformers, each subarray is transformed to a virtual element with appropriate directivity. Consequently, the whole UCCA can be viewed as a virtual uniform circular array (UCA) with desired element directivity for broadband processing. By extending the approach for designing FI-UCAs, the frequency dependency of the phase modes of the virtual UCA is compensated to facilitate broadband DOA and adaptive beamforming. Both the linear array beamformers (LABFs) and compensation filters can be designed separately using second- order cone programming (SOCP). Moreover, a new method to tackle the possible noise amplification problem in such large arrays by imposing additional norm constraints on the design of the compensation filters is proposed. The advantages of this decoupled approach are 1) the complicated design problem of large UCCAs can be decoupled into simpler problems of designing the LABFs and compensation filters, and 2) directional elements, which are frequently encountered, can be treated readily under the proposed framework. Numerical examples are provided to demonstrate the effectiveness and improvement of the proposed methods in DOA estimation, adaptive beamforming, and elevation control over the conventional FI-UCCA design method.
Intact LIM 3 and LIM 4 Domains of Paxillin Are Required for the Association to a Novel Polyproline Region (Pro 2) of Protein-Tyrosine Phosphatase-PEST*

The focal adhesion protein p130Cas was identified as a substrate for the protein-tyrosine phosphatase (PTP)-PEST, and the specificity of this interaction is mediated by a dual mechanism involving a Src homology 3 domain-mediated binding and PTP domain recognition. Recently, paxillin was also demonstrated to interact with PTP-PEST (Shen, Y., Schneider, G., Cloutier, J. F., Veillette, A., and Schaller, M. D. (1998) J. Biol. Chem. 273, 6474–6481). In the present study, we show that amino acids 344–397 of PTP-PEST are sufficient for the binding to paxillin. We demonstrate that a proline-rich segment of PTP-PEST (Pro 2),355PPEPHPVPPILTPSPPSAFP374, is essential for this interaction in vivo. Furthermore, mutation of proline residues within the Pro 2 motif reveal that proline 362 is critical for the binding of paxillin. Conversely, using deletion and point mutants of paxillin, LIM 3 and 4 domains were both found to be necessary for binding of PTP-PEST. Finally, using a “substrate trapping” approach, we demonstrate that, unlike p130Cas, paxillin is not a substrate for PTP-PEST. In conclusion, we show that a novel proline-rich motif found in PTP-PEST serves as a ligand for the LIM domains of paxillin. Interestingly, the focal adhesion targeting of paxillin is mediated by LIM 3. Thus, we propose that PTP-PEST, by a competition with the ligand of paxillin in the focal adhesion complex, could contribute to the removal of paxillin from the adhesion sites and consequently promote focal adhesion turnover.
Assessment of antiretroviral therapy by plasma viral load testing: standard and ICD HIV-1 p24 antigen and viral RNA (QC-PCR) assays compared.

To assess the utility of quantitative competitive-polymerase chain reaction (QC-PCR) measurements of plasma human immunodeficiency virus type 1 (HIV-1) RNA and other viral load markers for assessment of antiretroviral therapy, we used archived cryopreserved specimens from a randomized controlled clinical trial of 135 patients (CD4+ T cell count < or = 500/mm3), comparing zidovudine (500 mg/day) versus the nonnucleoside reverse transcriptase inhibitor L-697, 661 (50, 300, or 1,000 mg daily). We evaluated treatment-associated changes in plasma viral load by standard and immune complex-dissociated (ICD) HIV-1 p24 antigen assays, and, in a representative subset of patients (n = 46), by QC-PCR determination of virion-associated HIV-1 RNA. At baseline, HIV-1 RNA was quantifiable by QC-PCR in all patients tested (100%), whereas standard and ICD HIV-1 p24 antigen tests were positive (> or = 30 pg/ml) in 42% and 56%, respectively. All viral load parameters showed significant decreases from baseline within 1 week of initiation of zidovudine, as measured by standard p24 antigen assay, ICD p24 assay, and QC-PCR. At 1 week, patients treated with either 300 or 1,000 mg/day of L-697,661 showed significant decreases from baseline in plasma standard and ICD p24 antigen and QC-PCR-determined HIV-1 RNA levels. Whereas viral load decreases seen with zidovudine were sustained for the duration of treatment, plasma viral markers often returned to pretreatment levels despite ongoing L-697,661 treatment, with evidence of the emergence of drug-resistant virus. Whereas standard p24, ICD p24, and viral RNA levels changed similarly in response to treatment, the superior sensitivity and available dynamic range of plasma viral RNA assays like QC-PCR analysis provide an advantage for clinical monitoring of plasma viral load, allowing tracking of treatment-related changes even in patients with earlier stage disease and lower levels of viral load.
The radical innovation affecting competitive advantage of the Thai furniture industry

Radical innovation has been considered as a main source of competitive advantage for Thai furniture industry which is the important industrial sector that needs creative ideas, skills to increase value added and industrial value. Innovative capability of firms in this industry is also required in order to enable them to survive and prosper in face of increasing both local and foreign competitors. This research aims to develop a structural model of radical innovation and the relevant factors of market orientation, organizational learning, and entrepreneurial orientation affecting competitive advantage of firms in the furniture industry. The populations of this study are the top executives and marketing managers of 4,118 firms in the furniture industry. The research methodologies applied are both in-depth interviews and 7-point Likert scale questionnaires. The result from value of this research will be a structural model of innovation that can be applied to improve competitive advantage of firms in the furniture industry.
Venlafaxine extended-release treatment of hoarding disorder

Hoarding disorder, classified as a separate disorder in Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5), is a common, chronic, and potentially disabling syndrome that can be difficult to treat. Only one previous study prospectively measured response to pharmacotherapy in compulsive hoarders, finding that hoarders responded as well to paroxetine as did nonhoarding obsessive-compulsive disorder patients. However, paroxetine was not tolerated well in that study, and the overall response was moderate. Therefore, we conducted an open-label trial of venlafaxine extended-release for hoarding disorder. Twenty-four patients fulfilling the DSM-5 criteria for hoarding disorder were treated with venlafaxine extended-release for 12 weeks. All patients were free of psychotropic medications for at least 6 weeks before the study. No other psychotropic medications, cognitive-behavioral therapy, organizers, or cleaning crews were permitted during the study. To measure the severity of hoarding, the Saving Inventory-Revised (SI-R) and the UCLA Hoarding Severity Scale (UHSS) were administered before and after treatment. Twenty-three of the 24 patients completed treatment. Hoarding symptoms improved significantly, with a mean 36% decrease in UHSS scores and a mean 32% decrease in SI-R scores. Sixteen of the 23 completers (70%) were classified as responders to venlafaxine extended-release. These results suggest that venlafaxine extended-release may be effective for the treatment of hoarding disorder.
The Responsive Workbench [virtual work environment]

The Responsive Workbench concept was developed as an alternative to the multimedia and virtual reality systems of the past decade. It was recognized that almost nobody wants simulations of their working worlds in a desktop environment. Generally. users want to focus on their tasks rather than on operating the computer. The Responsive Workbench is a virtual working environment that locates virtual objects and control tools on a real "workbench". The objects-computer-generated stereo images-are projected onto the surface of a workbench. This setting corresponds to the actual work situation in an architect's office, in surgery, and so forth. A human guide uses the virtual working environment while several collaborators watch events through stereo shutter glasses. The participants operate within a nonimmersive virtual environment. Depending on the application, the virtual workbench can integrate various input and output modules, such as motion, gesture, and voice recognition systems. This characterizes the general trend away from the classical human-machine interface. Several guides can work together in similar environments either locally or by using broadband communication networks. A responsive environment, consisting of powerful graphics workstations, tracking systems, cameras, projectors, and microphones, replaces the traditional multimedia desktop workstation. <<ETX>>