Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic Significance of Body Mass Index in Asian Patients With Localized Renal Cell Carcinoma

We investigated the prognostic value of BMI (body mass index) in Asian patients with RCC (renal cell carcinoma). We evaluated 170 Asian patients who underwent surgery for localized RCC (pathologic T1-4 tumors in the absence of nodal or distant metastases) between 1996 and 2004 at our institution. Patients were stratified by BMI: 22 or less vs. greater than 22. Overall, CSS (cancer-specific survival) and RFS (recurrence-free survival) was estimated using the Kaplan-Meier method. Multivariate analysis was performed with the Cox regression model. The mean age and BMI of all patients was 62.4 ± 11.4 yr and 23.1 ± 3.2 kg/m2, respectively. Patients’ population consisted of 114 (67.1%) men and 56 (32.9%) women. The median follow-up was 50 mo. The BMI was less than 22 in 83 (49%) patients and greater than 22 in 87 (51%). There was a trend toward worse Eastern Cooperative Oncology Group (ECOG) performance status, less likely to have an incidentaloma, higher pathological stage, and more frequent microvascular invasion with lower BMI. Only the correlations between BMI and ECOG performance status (P = 0.003) and pathological stage (P = 0.015) were statistically significant. Of other relevant factors including gender, mode of presentation, ECOG performance status, C-reactive protein, histological type, Fuhrman nuclear grade, microvascular invasion, pathological stage, and adjuvant cytokine therapy, smaller BMI remained an independent predictor for worse CSS (44.5 mo vs. 56.0 mo, P = 0.041, HR = 10.99) and RFS (43.0 mo vs. 55.0 mo, P = 0.03, HR = 2.653), but not for OS (overall survival) (46.0 mo vs. 55.5 mo, P = 0.13, HR = 2.217) on multivariate analysis. Our findings identify increasing BMI in the Asian population as an independent predictor for favorable CSS and RFS in patients with RCC treated by surgery. Further studies, including a multiinstitutional, prospective Asian cohort, are required to confirm these findings.
Global template matching for guiding the learning of human detector

This work investigates a semantic-driven human detection algorithm, which employs global human template matching to inspire the local features based Adaboosting algorithm. We use distance transform to analyze distances between training samples and human contour template to obtain a classifier based on human outline features. At the training stage, the global outline feature will be coordinated into the Adaboost framework to guide the learning of a set of HOGs local classifiers. In other words, we make a stronger human classifier by dynamically tuning the hyper-plane of the support vector machine to combine both global and local features for attaining a better accuracy. A global fused error rate is also proposed to enhance the modified Adaboost iterative calculation such that a human detector called strong classifier can be obtained. The experiments illustrate that the detection rate received from the presented framework is above 20% better than original HOGs-based human detector.
Fuzzy Keyword Search with Safe Index over Encrypted Cloud Computing

As cloud computing becomes more and more utilized, sensitive data are being stored in cloud central servers. To ensure privacy, these data are usually encrypted before uploading, which makes searching complicated. In this paper we propose architecture of fuzzy keyword search with safe index. Bloom filter is used to build safe index which increases the searching effectiveness on a large dataset. The size of index is fixed so that the space efficiency is promoted. The experiment result shows that our searching scheme is effective and can be adapted to large encrypted file system. DOI: http://dx.doi. org/10.11591/telkomnika.v11i10. 3419
TREE: Routing strategy with guarantee of QoS for industrial wireless sensor networks

As considerable progress has been made in wireless sensor networks (WSNs), we can expect that sensor nodes will be applied in industrial applications. Most available techniques for WSNs can be transplanted to industrial wireless sensor networks (IWSNs). However, there are new requirements of quality of service (QoS), that is, real‐time routing, energy efficiency, and transmission reliability, which are three main performance indices of routing design for IWSNs. As one‐hop neighborhood information is often inadequate to data routing in IWSNs, it is difficult to use the conventional routing methods. In the paper, we propose the routing strategy by taking the real‐time routing performance, transmission reliability, and energy efficiency (TREE, triple R and double E) into considerations. For that, each sensor node should improve the capability of search range in the phase of data route discovery. Because of the increase of available information in the enlarged search range, sensor node can select more suitable relay node per hop. The real‐time data routes with lower energy cost and better transmission reliability will be used in our proposed routing guideline. By comparing with other routing methods through extensive experimental results, our distributed routing proposal can guarantee the diversified QoS requirements in industrial applications. Copyright © 2012 John Wiley & Sons, Ltd.
A PID autotuner utilizing GPC and constraint optimization

A solution to the PID autotuning problem is presented which involves constraining the parameters of a discrete second-order discrete-time controller. The integrator is forced into the regulator by using a CARIMA model. The discrete-time regulator parameters are calculated by optimizing a generalized predictive control criterion, and the PID structure is ensured by constraining the parameters to a feasible set defined by the discrete-time Euler approximation of the ideal continuous-time PID controller. The algorithm is extended by incorporating constraints on the amplitude and slew-rate of the control signal. Simulation studies for a system of coupled tanks have indicated that the method performs well, and that signal limitations can be included in a straightforward manner. <<ETX>>
On convergence rates of Bayesian predictive densities and posterior distributions

Frequentist-style large-sample properties of Bayesian posterior distributions, such as consistency and convergence rates, are important considerations in nonparametric problems. In this paper we give an analysis of Bayesian asymptotics based primarily on predictive densities. Our analysis is unified in the sense that essentially the same approach can be taken to develop convergence rate results in iid, mis-specified iid, independent non-iid, and dependent data cases.
A novel method on adaptive backstepping control of buck choppers

In this paper, a novel method for designing Buck chopper controller based on adaptive backstepping is presented. This method is based on accurate modeling of converter considering effect of circuit parasitic elements, better modeling of semiconductor switches and assuming equivalent series resistance of inductor. Also, during controller design process, all the parameters existing in model assumed to be uncertain and an appropriate estimation of these parameters is done by choosing a suitable Lyapunov function. It should be mentioned that in all of the design equations, input voltage of the converter assumed to be time-variant. Simulation results clearly show that designed controller has zero steady-state error and fast dynamic response. More over it can stabilize the converter during wide variation of load resistance and input voltage through inductor saturation.
A refined ant colony algorithm for optimal path planning

To solve optimization problems in path planning, many methods have been proposed. One of these methods is to mimic ant's behavior in path finding, formally named as Ant Colony Optimization (ACO) algorithm. Since first proposed in the nineties of the last century, this algorithm has attracted a lot of attention of researchers and scientists. Many modified versions of the algorithm have been investigated to accelerate the decision process for the determination of the optimal solution. This paper presents a refined ACO algorithm, which is an integration in principle of several approaches of ACO algorithm, with Multiple Ant Colonies Algorithm plays the main role. Some simulations are performed to show its overwhelming performance in solving path finding problem.
Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression

Cancer cells metabolize glucose at elevated rates and have a higher sensitivity to glucose reduction. However, the precise molecular mechanisms leading to different responses to glucose restriction between normal and cancer cells are not fully understood. We analyzed normal WI‐38 and immortalized WI‐38/S fetal lung fibroblasts and found that glucose restriction resulted in growth inhibition and apoptosis in WI‐38/S cells, whereas it induced lifespan extension in WI‐38 cells. Moreover, in WI‐38/S cells glucose restriction decreased expression of hTERT (human telomerase reverse transcriptase) and increased expression of p16INK4a. Opposite effects were found in the gene expression of hTERT and p16 in WI‐38 cells in response to glucose restriction. The altered gene expression was partly due to glucose restriction‐induced DNA methylation changes and chromatin remodeling of the hTERT and p16 promoters in normal and immortalized WI‐38 cells. Furthermore, glucose restriction resulted in altered hTERT and p16 expression in response to epigenetic regulators in WI‐38 rather than WI‐38/S cells, suggesting that energy stress‐induced differential epigenetic regulation may lead to different cellular fates in normal and precancerous cells. Collectively, these results provide new insights into the epigenetic mechanisms of a nutrient control strategy that may contribute to cancer therapy as well as antiaging approaches. —Li, Y. , Liu, L. , Tollefsbol, T. O. Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression. FASEB J. 24, 1442–1453 (2010). www.fasebj. org
Somatic cells derived from haploid larvae are feasible as donors for nuclear transplant in zebrafish. Preliminary results

Summary Somatic cells derived from zebrafish haploid larval (both androgenetic and gynogenetic) cultures were used as donors for nuclear transplant into non-enucleated oocytes. Nuclei were transplanted either before or simultaneously with oocyte activation in the central region and in the incipient animal pole, respectively. Against expected results, 20% of transplanted embryos during oocyte activation using cells of gynogenetic origin reached the 100% epiboly stage, even two survived for up to 5 days, whereas no development was observed when cells from androgenetic origin were used. Results derived from this work open a novel possibility of studying somatic cell reprogramming and imprinting phenomena in zebrafish.
Filter bank design for subband adaptive microphone arrays

This paper presents a new method for the design of oversampled uniform DFT-filter banks for the special application of subband adaptive beamforming with microphone arrays. Since array applications rely on the fact that different source positions give rise to different signal delays, a beamformer alters the phase information of the signals. This in turn leads to signal degradations when perfect reconstruction filter banks are used for the subband decomposition and reconstruction. The objective of the filter bank design is to minimize the magnitude of all aliasing components individually, such that aliasing distortion is minimized although phase alterations occur in the subbands. The proposed method is evaluated in a car hands-free mobile telephony environment and the results show that the proposed method offers better performance regarding suppression levels of disturbing signals and much less distortion to the source speech.
Imputation of missing data when measuring physical activity by accelerometry.

PURPOSE We consider the issue of summarizing accelerometer activity count data accumulated over multiple days when the time interval in which the monitor is worn is not uniform for every subject on every day. The fact that counts are not being recorded during periods in which the monitor is not worn means that many common estimators of daily physical activity are biased downward. METHODS Data from the Trial for Activity in Adolescent Girls (TAAG), a multicenter group-randomized trial to reduce the decline in physical activity among middle-school girls, were used to illustrate the problem of bias in estimation of physical activity due to missing accelerometer data. The effectiveness of two imputation procedures to reduce bias was investigated in a simulation experiment. Count data for an entire day, or a segment of the day were deleted at random or in an informative way with higher probability of missingness at upper levels of body mass index (BMI) and lower levels of physical activity. RESULTS When data were deleted at random, estimates of activity computed from the observed data and those based on a data set in which the missing data have been imputed were equally unbiased; however, imputation estimates were more precise. When the data were deleted in a systematic fashion, the bias in estimated activity was lower using imputation procedures. Both imputation techniques, single imputation using the EM algorithm and multiple imputation (MI), performed similarly, with no significant differences in bias or precision. CONCLUSIONS Researchers are encouraged to take advantage of software to implement missing value imputation, as estimates of activity are more precise and less biased in the presence of intermittent missing accelerometer data than those derived from an observed data analysis approach.
Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells

Casitas B-cell lymphoma (Cbl)-family E3 ubiquitin ligases are negative regulators of tyrosine kinase signaling. Recent work has revealed a critical role of Cbl in the maintenance of hematopoietic stem cell (HSC) homeostasis, and mutations in CBL have been identified in myeloid malignancies. Here we show that, in contrast to Cbl or Cbl-b single-deficient mice, concurrent loss of Cbl and Cbl-b in the HSC compartment leads to an early-onset lethal myeloproliferative disease in mice. Cbl, Cbl-b double-deficient bone marrow cells are hypersensitive to cytokines, and show altered biochemical response to thrombopoietin. Thus, Cbl and Cbl-b play redundant but essential roles in HSC regulation, whose breakdown leads to hematological abnormalities that phenocopy crucial aspects of mutant Cbl-driven human myeloid malignancies.
Three novel deletions in the alanine:glyoxylate aminotransferase gene of three patients with type 1 hyperoxaluria.

We describe three novel deletions in the human AGT gene in three patients with primary hyperoxaluria type 1, an autosomal recessive disease resulting from a deficiency of the liver peroxisomal enzyme, alanine glyoxylate aminotransferase (AGT; EC 2.6.1.44). A deletion of 4 nucleotides in the exon 6/intron 6 splice junction (679-IVS6+2delAAgt) is expected to cause missplicing. It would also code for a K227E missense alteration in any mRNA successfully spliced. A 2-bp deletion in exon 11 (1125-1126del CG, cDNA) results in a frameshift. A deletion of at least 5-6 kb, EX1 EX5del, spanned exons 1-5 and contiguous upstream sequence. All three deletions are heterozygous with previously documented missense mutations; the intron 6 deletion with F152I, the exon 11 deletion with G82E, and EX1 EX5del with the common mistargeting mutation, G170R.
Draft Genome Sequence of Botrytis cinerea BcDW1, Inoculum for Noble Rot of Grape Berries

ABSTRACT Botrytized wines are produced from grape berries infected by Botrytis cinerea under specific environmental conditions. Here, we report the draft genome sequence of B. cinerea BcDW1, a strain isolated from Sémillon grapes in Napa Valley in 1992 that is used with the intent to induce noble rot for botrytized wine production.
Using CDC's health-related quality of life scale on a college campus.

OBJECTIVES To evaluate the performance of the US Centers for Disease Control's health-related quality of life (HRQOL) scale among 522 college students. METHODS Chi-square analysis assessed scale construct validity and analysis of variance (ANOVA) with selected tobacco, alcohol, and substance use variables assessed known-groups validity of the scale's Healthy Days index. RESULTS Patterns of association among scale items were consistent with those hypothesized. ANOVA analyses revealed significant (P<.05) associations between the Healthy Days index and selected variables in predicted directions. CONCLUSIONS Preliminary evidence is provided that the HRQOL scale could serve as part of program evaluation, intervention, and surveillance efforts among college students.
Local intra‐arterial thrombolysis in a 4‐year‐old male with vertebrobasilar artery thrombosis

We report the case of a 4‐year‐old male with vertebrobasilar artery thrombosis for which he was treated with local intra‐arterial urokinase 60 hours after onset of symptoms. Initially the patient had dysarthria and dysphagia. Brain magnetic resonance imaging (MRI) in a community hospital showed abnormalities in the pons, and vertebrobasilar artery thrombosis was suspected. The patient was transferred to the university hospital because of neurological deterioration. Just before thrombolysis, his physical examination revealed a downward ocular deviation, stretching of the arms, and spontaneous movements of the legs. Brain MRI showed recent ischaemia in the pons and caudal part of the mesencephalon, and magnetic resonance angiography showed occlusion of the basilar artery. Intra‐arterial thrombolysis with urokinase (total dose 36 000U/kg) was performed 60 hours after onset of symptoms. After thrombolysis he was treated with heparin for 10 days, followed by aspirin. The patient recovered well. After 1 year he had only minor ataxia and performed all activities at school. Local vasculitis due to an infection with Borrelia burgdorferi was thought to be the cause of the local thrombosis. A review of the literature revealed 11 other case reports of successful local intra‐arterial thrombolysis in children and adolescents with ischaemic stroke. This suggests that intra‐arterial thrombolysis is feasible and safe in selected paediatric patients with ischaemic stroke.
GYROSCOPIC PUMPING OF LARGE-SCALE FLOWS IN STELLAR INTERIORS AND APPLICATION TO LITHIUM-DIP STARS

The maintenance of large-scale differential rotation in stellar convective regions by rotationally influenced convective stresses also drives large-scale meridional flows by angular-momentum conservation. This process is an example of “gyroscopic pumping” and has recently been studied in detail in the solar context. An important question concerns the extent to which these gyroscopically pumped meridional flows penetrate into nearby stably stratified (radiative) regions, since they could potentially be an important source of non-local mixing. Here, we present an extensive study of the gyroscopic pumping mechanism, using a combination of analytical calculations and numerical simulations both in Cartesian geometry and in spherical geometry. The various methods, when compared with one another, provide physical insight into the process itself, as well as increasingly sophisticated means of estimating the gyroscopic pumping rate. As an example of application, we investigate the effects of this large-scale mixing process on the surface abundances of the light elements Li and Be for stars in the mass range 1.3–1.5 M☉ (the so-called Li-dip stars). We find that gyroscopic pumping is a very efficient mechanism for circulating material between the surface and the deep interior, so much in fact that it overestimates Li and Be depletion by orders of magnitude for stars on the hot side of the dip. However, when the diffusion of chemical species back into the surface convection zone is taken into account, a good fit with observed surface abundances of Li and Be as a function of stellar mass in the Hyades cluster can be found for reasonable choices of model parameters.
A study on quality evaluation for travel agency's website

As finding and purchasing travel and tourism product through travel agency's website has become general practice in the market place, travel agencies exert themselves to improve quality of web site to attract maximum consumer satisfaction which has direct influence on market competitiveness. In developing quality evaluation model, this research focused on functional aspects as well as technical aspects of website and conducted empirical research on what and how the combined attributes affect agency's website quality to suggest travel agency effective ways of constructing, operating and marketing website
Human-Explainable Features for Job Candidate Screening Prediction

Video blogs (vlogs) are a popular media form for people to present themselves. In case a vlogger would be a job candidate, vlog content can be useful for automatically assessing the candidates traits, as well as potential interviewability. Using a dataset from the CVPR ChaLearn competition, we build a model predicting Big Five personality trait scores and interviewability of vloggers, explicitly targeting explainability of the system output to humans without technical background. We use human-explainable features as input, and a linear model for the systems building blocks. Four multimodal feature representations are constructed to capture facial expression, movement, and linguistic usage. For each, PCA is used for dimensionality reduction and simple linear regression for the predictive model. Our system’s accuracy lies in the middle of the quantitative competition chart, while we can trace back the reasoning behind each score and generate a qualitative analysis report per video.
A read-static-noise-margin-free SRAM cell for low-VDD and high-speed applications

To help overcome limits to the speed of conventional SRAMs, we have developed a read-static-noise-margin-free SRAM cell. It consists of seven transistors, several of which are low-Vth nMOS transistors used to achieve both low-VDD and high-speed operations. For the same speed, the area of our proposed SRAM is 23% smaller than that of a conventional SRAM. Further, we have fabricated a 64-kb SRAM macro using 90-nm CMOS technology and have obtained with it a minimum VDD of 440 mV and a 20-ns access time with a 0.5-V supply.