Miracle-dz/UniFAR-FTUs huggingface dataset:
In-office treatment for dentin hypersensitivity: a systematic review and network meta-analysis.

AIM Dentin hypersensitivity, caused by the exposure and patency of dentinal tubules, can affect patients' quality of life. The aim of this study was to undertake a systematic review and a network meta-analysis, comparing the effectiveness in resolving dentin hypersensitivity among different in-office desensitizing treatments. MATERIALS AND METHODS A literature search was performed with electronic databases and by hand until December 2011. The included trials were divided into six treatment groups as placebo, physical occlusion, chemical occlusion, nerve desensitization, laser therapy and combined treatments. The treatment effects between groups were estimated with standardized mean differences by using a Bayesian network meta-analysis. RESULTS Forty studies were included. The standardized mean difference between placebo and physical occlusion was -2.57 [95% credible interval (CI): -4.24 to -0.94]; placebo versus chemical occlusion was -2.33 (95% CI: -3.65 to -1.04); placebo versus nerve desensitization was -1.72 (95% CI: -4.00 to 0.52); placebo versus laser therapy was -2.81 (95% CI: -4.41 to -1.24); placebo versus combined treatment was -3.47 (95% CI: -5.99 to -0.96). The comparisons of the five active treatments showed no significant differences. CONCLUSIONS The results from network meta-analysis showed that most active treatment options had significantly better treatment outcome than placebo.
Detecting Inner-Ear Anatomical and Clinical Datasets in the Linked Open Data (LOD) Cloud

Linked Open Data (LOD) Cloud is a mesh of open datasets coming from dierent domains. Among these datasets, a notable amount of datasets belong to the life sciences domain linked together forming an interlinked \Life Sciences Linked Open Data (LSLOD) Cloud". One of the key challenges for data publishers is to identify and establish links between newly generated domain specic datasets and LSLOD Cloud. While a number of publishing tools exist for creating links from new to existing datasets, tools to detect domain-specic relevant datasets for linking purposes are missing. In this paper, we propose an extended technique for automatically identifying relevant datasets in LSLOD Cloud for inner-ear anatomical and clinical terminologies. We validate the proposed technique with experiments over the publicly accessible LSLOD Cloud using real- world terminologies and datasets provided by clinical organizations.
Comparing One Repetition Maximum and Three Repetition Maximum Between Conventional and Eccentrically Loaded Deadlifts

Abstract Bishop, A, DeBeliso, M, Sevene, TG, and Adams, KJ. Comparing one repetition maximum and three repetition maximum between conventional and eccentrically loaded deadlifts. J Strength Cond Res 28(7): 1820–1825, 2014—This study determined if an eccentrically loaded deadlift yields a higher 1 repetition maximum (1RM) and 3RM than a conventional deadlift and if the 1RM conventional and eccentrically loaded deadlift can be accurately estimated from the 3RM (3RM = 93% of 1RM). Division 1 football players (n = 15; 20.3 ± 1.9 years; 95.8 ± 18.2 kg; 184.4 ± 6.6 cm) participated. Deadlift 1RM and 3RM were measured in the conventional and eccentrically loaded deadlift. Dependent t-tests showed no significant difference between the 3RM and 1RM conventional deadlift and the 3RM and 1RM eccentrically loaded deadlift (p = 0.30 and p = 0.20, respectively). Pearson correlation between the 1RM conventional deadlift estimate and 1RM conventional deadlift actual was r = 0.91 (p ⩽ 0.01); a dependent t-test indicated the 1RM conventional deadlift estimate was significantly less than the 1RM conventional deadlift actual (p = 0.007). Pearson correlation between the 1RM eccentrically loaded deadlift estimate and 1RM eccentrically loaded deadlift actual was r = 0.84 (p ⩽ 0.01); a dependent t-test indicated the 1RM eccentrically loaded deadlift estimate was nearly significantly less than the 1RM eccentrically loaded deadlift actual (p = 0.061). Results suggest that conventional and eccentrically loaded deadlifts may be interchangeable within a training program; this may elicit the benefits of using a broader variety of ground-based multijoint compound movements in an athlete's strength and power training. Additionally, because of differences between predicted and actual 1RM scores in the deadlift, strength coaches should prioritize actual 1RM testing of their athletes to optimize deadlift training loads across the RM continuum.
Influence of Grain Boundary on Activation of Slip Systems in Magnesium: Crystal Plasticity Analysis

Crystal plasticity finite element analysis method considering the accumulation of geometrically necessary (GN) dislocations was applied to monotonic loading of pure magnesium bi-crystal. The deformation mechanisms considering in the present analysis method are basal slip , prismatic slip , 1st order pyramidal slip , 2nd order pyramidal slip and tensile twinning . Tensile twinning is incorporated into crystal plasticity analysis assuming that twinning plane and direction of shear by twinning are equivalent to slip plane and slip direction, respectively. Critical resolved shear stresses (CRSSs) for each slip system in the literatures were used. Analysis model is designed to investigate the influence of grain boundary on the activation of slip systems. That is, one grain consisting of bi-crystal (grain A) had the crystal orientation whose Schmid factor for prismatic slip is 0.5. The crystal orientation of the other grain (grain B) was slightly deviated from that of grain A. The result of the calculation of tensile loading of the bi-crystal showed that both grains are deformed by the multiple slip of basal slip system, which resulted in the formation of GN dislocation bands.
Torque coordinated control of PHEV based on the fuzzy and sliding mode method with load torque observer

Due to the torque fluctuation in the mode transition caused by the different response speed of motor and engine, a novel torque coordinated control strategy is proposed in this paper. First, a simplified model of parallel hybrid electric vehicle(PHEV) is constructed. Then a coordinated control method based on the sliding mode control is studied. In order to improve the control performance, the fuzzy control is used to adjust the switching gain of the sliding mode control, and an observer is designed to estimate the load torque in order to improve the ability of resisting load disturbance. In the end, the simulation model of vehicle power system is established in Matlab/Simulink, and the simulation results show that the method can reduce the torque ripple effectively, which will contribute to improve the comfort of the vehicle.
Linear Image Upscaling :A Reveiw

Image upscaling is an important field of digital image processing. It is often required to create higher resolution images from the lower resolution images at hand in computer graphics, media devices, satellite imagery etc. Upscaling is also referred to as 'single image super- resolution'. Upscaling an image does not add new definition in the image, it increases the spatial resolution of the image and thus the total number of pixels in the image. The process of upscaling is a tradeoff between efficiency, computation time and the quality of output images obtained. Upscaling introduces some level of artifacts or blurriness in the output image. This paper is a brief review of some linear methods of image interpolation.
Frequency-Dependent Magnetic Susceptibility of Magnetite and Cobalt Ferrite Nanoparticles Embedded in PAA Hydrogel

Chemically responsive hydrogels with embedded magnetic nanoparticles are of interest for biosensors that magnetically detect chemical changes. A crucial point is the irreversible linkage of nanoparticles to the hydrogel network, preventing loss of nanoparticles upon repeated swelling and shrinking of the gel. Here, acrylic acid monomers are adsorbed onto ferrite nanoparticles, which subsequently participate in polymerization during synthesis of poly(acrylic acid)-based hydrogels (PAA). To demonstrate the fixation of the nanoparticles to the polymer, our original approach is to measure low-field AC magnetic susceptibility spectra in the 0.1 Hz to 1 MHz range. In the hydrogel, the magnetization dynamics of small iron oxide nanoparticles are comparable to those of the particles dispersed in a liquid, due to fast Néel relaxation inside the particles; this renders the ferrogel useful for chemical sensing at frequencies of several kHz. However, ferrogels holding thermally blocked iron oxide or cobalt ferrite nanoparticles show significant decrease of the magnetic susceptibility resulting from a frozen magnetic structure. This confirms that the nanoparticles are unable to rotate thermally inside the hydrogel, in agreement with their irreversible fixation to the polymer network.
Characterisation of an antibody specific for coagulation factor VIII that enhances factor VIII activity

Summary Many reports have identified factor (F)VIII inhibitory antibodies with epitopes located in all subunits of the FVIII molecule. Antibodies that promote FVIII activity do not appear to have been reported. We characterised, for the first time, a unique anti-FVIII monoclonal antibody, mAb216, that enhanced FVIII coagulant activity. The mAb216 shortened the activated partial thromboplastin time and specifically increased FVIII activity by ~1.5-fold dose-dependently. FXa generation and thrombin generation were similarly increased by ~1.4- and ~2.5-fold, respectively. An A2 epitope, not overlapping the common A2 epitope, was identified and the antibody was shown to enhance thrombin (and FXa)-catalysed activation of FVIII by modestly accelerating cleavage at Arg372. The presence of mAb216 mediated an ~1.5-fold decrease in Km for the FVIII-thrombin interaction. Enhanced FVIII activity was evident to an equal degree, even the presence of anti-FVIII neutralising antibodies with epitopes in each subunit. In addition, mAb216 depressed the rates of heat-denatured loss of FVIII activity and FVIIIa decay by 2 to ~2.5-fold. We have developed an anti-A2, FVIII mAb216 that augmented procoagulant activity. This enhancing effect could be attributed to an increase in thrombin-induced activation of FVIII, mediated by cleavage at Arg372 and a tighter interaction of thrombin with the A2 domain. The findings may cast new light on new principles for improving the treatment of haemophilia A patients.
Why Does the “Sinner” Act Prosocially? The Mediating Role of Guilt and the Moderating Role of Moral Identity in Motivating Moral Cleansing

Numerous studies have found that people tend to commit prosocial acts subsequent to previous immoral acts, as a response to the latter. This phenomenon is called moral cleansing or moral compensation. However, the specific mechanism how previous immoral acts motivate moral compensatory behaviors is still not fully understood. This study aimed to examine the roles of guilt and moral identity in the relation between previous immoral acts and subsequent prosocial behaviors to clarify the mechanism. Based on the extant research, the current study proposed a moderated mediation model to illustrate the process of moral cleansing. Specifically, a previous immoral act motivates guilt, which further leads to subsequent prosocial behaviors, while moral identity facilitates this process. The participants were primed by a recalling task (immoral act vs. a neutral event). The results support the hypothesized model and provide a framework that explains moral cleansing by integrating the roles of guilt and moral identity. These findings highlight the dynamic nature of people’s morality with regard to how people adapt moral behaviors to protect their moral self-image.
Lipid A antiserum-mediated protection against lipopolysaccharide- and lipid A-induced fever and skin necrosis

The antiendotoxic activity of lipid A antiserum was studied in rabbits, using lipid A (lipopolysaccharide)-induced fever and skin necrosis as test systems. It was found that lipid A antiserum had no significant antipyretic effect when it was incubated with lipid A or injected intravenously before lipid A challenge. However, in animals that were pretreated (day 0) with a single dose of lipid A (lipopolysaccharide), a significant protective effect of passively transferred antiserum (day 1) to lipid A (lipopolysaccharide fever) (day 2) was observed. Also, the lipid A (lipopolysaccharide)-induced local shwartzman reaction could be prevented by lipid A antiserum. In the fever system, the degree of protection depended on the preparative and the challenge doses as well as on the amount of antiserum transferred. The fever protection mediated by lipid A antiserum seemed to be lipid A (lipopolysaccharide) specific with regard to both the preparative and the challenge injections. Lipid A specificity of the protective factor present in the antiserum was indicated by the fauggest that the factor might be identical with lipid A-specific immunoglobulin. The significance of the preparative injection is not understood at the present time. Iti is concluded, however, that in the fever protection system described, besides specific humoral factors, other factors, perhaps cellular, are involved.
Construction and Applications of CRT Sequences

Protocol sequences are used for channel access in the collision channel without feedback. Each user accesses the channel according to a deterministic zero-one pattern, called the protocol sequence. In order to minimize fluctuation of throughput due to delay offsets, we want to construct protocol sequences whose pairwise Hamming cross-correlation is as close to a constant as possible. In this paper, we present a construction of protocol sequences which is based on the bijective mapping between one-dimensional (1-D) sequence and two-dimensional (2-D) arrays by the Chinese Remainder Theorem (CRT). In the application to the collision channel without feedback, a worst-case lower bound on system throughput is derived.
Functional Human α7 Nicotinic Acetylcholine Receptor (nAChR) Generated from Escherichia coli*

Human Cys-loop receptors are important therapeutic targets. High-resolution structures are essential for rational drug design, but only a few are available due to difficulties in obtaining sufficient quantities of protein suitable for structural studies. Although expression of proteins in E. coli offers advantages of high yield, low cost, and fast turnover, this approach has not been thoroughly explored for full-length human Cys-loop receptors because of the conventional wisdom that E. coli lacks the specific chaperones and post-translational modifications potentially required for expression of human Cys-loop receptors. Here we report the successful production of full-length wild type human α7nAChR from E. coli. Chemically induced chaperones promote high expression levels of well-folded proteins. The choice of detergents, lipids, and ligands during purification determines the final protein quality. The purified α7nAChR not only forms pentamers as imaged by negative-stain electron microscopy, but also retains pharmacological characteristics of native α7nAChR, including binding to bungarotoxin and positive allosteric modulators specific to α7nAChR. Moreover, the purified α7nAChR injected into Xenopus oocytes can be activated by acetylcholine, choline, and nicotine, inhibited by the channel blockers QX-222 and phencyclidine, and potentiated by the α7nAChR specific modulators PNU-120596 and TQS. The successful generation of functional human α7nAChR from E. coli opens a new avenue for producing mammalian Cys-loop receptors to facilitate structure-based rational drug design.
Proteogenomics in microbiology: Taking the right turn at the junction of genomics and proteomics

High‐accuracy and high‐throughput proteomic methods have completely changed the way we can identify and characterize proteins. MS‐based proteomics can now provide a unique supplement to genomic data and add a new level of information to the interpretation of genomic sequences. Proteomics‐driven genome annotation has become especially relevant in microbiology where genomes are sequenced on a daily basis and limitations of an in silico driven annotation process are well recognized. In this review paper, we outline different strategies on how one can design a proteogenomic experiment, for example on genome‐sequenced (synonymous proteogenomics) versus unsequenced organisms (ortho‐proteogenomics) or with the aid of other “omic” data such as RNA‐seq. We touch upon many challenges that are encountered during a typical proteogenomic study, mostly concerning bioinformatics methods and downstream data analysis, but also related to creation and use of sequence databases. A large list of proteogenomic case studies of different microorganisms is provided to illustrate the mapping of MS/MS‐derived peptide spectra to genomic DNA sequences. These investigations have led to accurate determination of translational initiation sites, pointed out eventual read‐throughs or programmed frameshifts, detected signal peptide processing or other protein maturation events, removed questionable annotation assignments, and provided evidence for predicted hypothetical proteins.
Fabrication of Micro-Cantilevers Using RF Magnetron Sputtered Silicon Carbide Films

In the present work, silicon carbide (SiC) films were deposited by RF magnetron sputtering process on Si (100) substrates for micro-cantilever fabrication. The films were deposited without external substrate heating using a ceramic SiC target at 10 mTorr sputtering pressure, 200 W power and 50 mm target-to-substrate spacing. X-ray diffraction pattern shows that the films were amorphous in nature. In order to investigate the chemical inertness, the SiC coated Si substrates were dipped in buffered HF (BHF) at room temperature and in 40% KOH solution at 80 °C for varying length of time. Atomic force microscope was used to investigate surface roughness and morphology of the films before and after chemical processing. Micro-cantilever beams of the SiC film were fabricated by a single mask process. The SiC film was patterned using reactive ion etching (RIE) in SF6-O2 plasma. Thermally evaporated Al film was used as a mask during RIE process. This process also resulted in the formation of convex corners which were exploited for anisotropic etching of Si under the SiC film. The SiC cantilever beams were released by anisotropic etching of Si in KOH at 80 °C without using additional masking material. Scanning electron microscopy was used to observe the fabricated SiC micro-cantilever beams. The morphology of the SiC film after prolonged exposure to KOH was observed to be similar to that of the as-deposited film. The RF magnetron sputtered SiC films were found to be highly inert in KOH and BHF solutions. Due to difficulty in micromachining of bulk SiC material and its high cost, the RF sputtered SiC films on Si can provide a low cost structural material in MEMS.
A 2D–3D integrated tabletop environment for multi‐user collaboration

This paper proposes a novel tabletop display system for natural communication and flexible information sharing. The proposed system is specifically designed to integrate two‐dimensional (2D) and three‐dimensional (3D) user interfaces by using a multi‐user stereoscopic display, IllusionHole. The proposed system takes awareness into consideration and provides both 2D and 3D information and user interfaces. On the display, a number of standard Windows desktop environments are provided as personal workspaces, as well as a shared workspace with a dedicated graphical user interface. In the personal workspaces, users can simultaneously access existing applications and data, and exchange information between personal and shared workspaces. In this way, the proposed system can seamlessly integrate personal, shared, 2D, and 3D workspaces with conventional user interfaces and effectively support communication and information sharing. To demonstrate the capabilities of the proposed display system, a modeling application was implemented. A preliminary experiment confirmed the effectiveness of this system. Copyright © 2006 John Wiley & Sons, Ltd.
Dendritic nonlinearities are tuned for efficient spike-based computations in cortical circuits

Cortical neurons integrate thousands of synaptic inputs in their dendrites in highly nonlinear ways. It is unknown how these dendritic nonlinearities in individual cells contribute to computations at the level of neural circuits. Here, we show that dendritic nonlinearities are critical for the efficient integration of synaptic inputs in circuits performing analog computations with spiking neurons. We developed a theory that formalizes how a neuron's dendritic nonlinearity that is optimal for integrating synaptic inputs depends on the statistics of its presynaptic activity patterns. Based on their in vivo preynaptic population statistics (firing rates, membrane potential fluctuations, and correlations due to ensemble dynamics), our theory accurately predicted the responses of two different types of cortical pyramidal cells to patterned stimulation by two-photon glutamate uncaging. These results reveal a new computational principle underlying dendritic integration in cortical neurons by suggesting a functional link between cellular and systems--level properties of cortical circuits. DOI: http://dx.doi. org/10.7554/eLife.10056. 001
Bulging Investigation of Cylinder Compression Forming Using Upper Bound Analysis

Bulging deformation during cylinder compression forming results in geometrical imprecision and flow stress prediction error. Consequently, the present study proposes a hybrid technique comprising the Upper Bound Method (UBM) and geometrical fitting method. It is noted that a volume conservation constraint and an elliptical curve-fitting method with UBM for predicting both the compression force and the bulge profile. It is shown that the predicted results for the compression force based on UBM under certain reduction ratios of 30%, 40%, 50% and 60% are in good agreement with those obtained by experiment, Finite Element Method (FEM), and Slab Method (SM). In addition, it is revealed that the use of an elliptical curve-fitting technique provides a reasonable approximation of the bulge profile obtained by experiment and FEM simulations. Generally, the proposed method effectively provides a low-cost, computationally straightforward means of estimating the compression force and bulge profile in cylinder compression forming. Therefore it can be utilized as the widespread applications in the metal forming field.
A 12.4μm2 133.4μW 4.56mV/°C resolution digital on-chip thermal sensing circuit in 45nm CMOS utilizing sub-threshold operation

Dynamic thermal management (DTM) schemes rely on physical sensors to provide them with feedback to ensure an accurate and closed-loop throttling mechanism. Power-density trends in current-generation, high-performance processors motivate the need for multiple low-area, low-power and high-sensitivity temperature monitoring circuits. To this end, we have proposed and implemented in 45nm CMOS, a novel, digital, on-chip thermal sensing circuit with a high thermal sensitivity of 4.56mV/ºC, low power dissipation of 133. 4μW and a compact layout occupying 12. 4μ2. The design is robust towards process and supply induced noise incurring a 1-σ accuracy loss of <=1. 24ºC for a +/-10% random variation in the physical and environmental parameters.