Miracle-dz/UniFAR-FTUs huggingface dataset:
Strategic Business Requirements for Master Data Management Systems

Master Data Management (MDM) is of increasing importance because it is seen as a promising approach in companies torespond to a number of strategic business requirements, such as complying with an increasing number of regulations,supporting internal and external business process integration, and establishing a 360-degree-view on the customer. As aresult, software vendors such as IBM, Oracle, SAP, and TIBCO are offering MDM application systems. However, the usercommunity feels a significant mismatch between their own strategic requirements and the functionality currently offered bythe software products. As the Information Systems (IS) research community has remained silent so far regarding this researchproblem, the research presented in this paper makes intensive use of knowledge from the practitioners' community in order todesign a framework for strategic business requirements to be met by MDM systems. As an outcome of a design-orientedresearch process, the framework is an artifact which advances the scientific body of knowledge while at the same timeproviding benefit for practitioners. The framework includes seven design principles which are translated into 23requirements. The requirements form a baseline for internal and external communication in companies and for the design ofconcrete MDM systems.
Retarded embryonic development and pregnancy termination in ovariectomized guinea-pigs: progesterone deficiency and decidual collapse.

Examination of serially sectioned conceptuses from ovariectomized female guinea pigs 12-16 days pregnant is reported. Ovariectomy was performed on Day 4 or 5 of pregnancy. Colcemid was administered 1 mg/kg body weight before death to facilitate comparisons of cell divisions. Progesterone was given in some cases to examine its effect on pregnancies of ovariectomized females. From Day 12 a conspicuous de generation of part of the decidua was seen to occur interfering with normal development in the adjacent placenta. Total collapse of the decidua with massive hemorrhage on Day 16 abolished surviving pregnancies. In the unmated guinea pig the deciduoma breaks down at the end of the 16-day cycle when corpora lutea regress before the next estrus. Progesterone in adequate doses given early in pregnancy to ovarietomized guniea pigs can prevent decidual degeneration. In cases where progesterone had been deferred until Day 14 areas of decidual deg eneration persist for some days.
NFX1-123 Increases hTERT Expression and Telomerase Activity Posttranscriptionally in Human Papillomavirus Type 16 E6 Keratinocytes

ABSTRACT High-risk human papillomavirus (HPV) E6 protein induces telomerase activity through transcriptional activation of hTERT, the catalytic subunit of telomerase. HPV type 16 (HPV16) E6 interacts with two splice variants of NFX1 to increase hTERT expression. NFX1-91 is a transcriptional repressor of hTERT that is polyubiquitinated and targeted for degradation by HPV16 E6 in concert with E6-associated protein. We previously showed that NFX1-123 augments hTERT expression through binding to cytoplasmic poly(A) binding proteins (PABPCs). In this study, we determined that unlike NFX1-91, NFX1-123 is a cytoplasmic protein that colocalized with PABPCs but does not shuttle with PABPCs between the nucleus and cytoplasm. NFX1-123 requires both its PAM2 motif, with which it binds PABPCs, and its R3H domain, which has putative nucleic acid binding capabilities, to increase hTERT mRNA levels and telomerase activity in keratinocytes expressing HPV16 E6. In keratinocytes expressing HPV16 E6 and overexpressing NFX1-123, there was increased protein expression from in vitro-transcribed RNA fused with the 5′ untranslated region (5′ UTR) of hTERT. This posttranscriptional increase in expression required the PAM2 motif and R3H domain of NFX1-123 as well as the coexpression of HPV16 E6. NFX1-123 bound endogenous hTERT mRNA and increased its stability in HPV16 E6-expressing human foreskin keratinocytes, and NFX1-123 increased the stability of in vitro-transcribed RNA fused with the 5′ UTR of hTERT. Together, these studies describe the first evidence of posttranscriptional regulation of hTERT, through the direct interaction of the cytoplasmic protein NFX1-123 with hTERT mRNA, in HPV16 E6-expressing keratinocytes.
Genew: the Human Gene Nomenclature Database

Genew, the Human Gene Nomenclature Database, is the only resource that provides data for all human genes which have approved symbols. It is managed by the HUGO Gene Nomenclature Committee (HGNC) as a confidential database, containing over 16 000 records, 80% of which are represented on the Web by searchable text files. The data in Genew are highly curated by HGNC editors and gene records can be searched on the Web by symbol or name to directly retrieve information on gene symbol, gene name, cytogenetic location, OMIM number and PubMed ID. Data are integrated with other human gene databases, e.g. GDB, LocusLink and SWISS-PROT, and approved gene symbols are carefully co-ordinated with the Mouse Genome Database (MGD). Approved gene symbols are available for querying and browsing at http://www.gene. ucl.ac. uk/cgi-bin/nomenclature/searchgenes.pl.
Decision-makers′ use of pharmacoeconomics: what does the research tell us?

Governments, organizations and industry routinely make decisions regarding the value of pharmaceuticals. The perspectives, techniques, decision constraints and available information differ across these decision–makers and sometimes within categories. Although pharmacoeconomics is consistent with the international trend toward evidence-based decisions in medicine and could benefit all of these decision-makers, the potential impact of these studies has been largely unrealized. Why is it that a field to which so much research funding has been devoted, has produced so little of clear use to major decision-makers? Would inflexible organizational barriers surrounding narrowly defined performance incentives and line item budget accountability limit the usefulness of even impeccably performed pharmacoeconomic studies? Or, are methodological and logistical considerations impeding the usefulness of pharmacoeconomics?
Dempster–Shafer Fusion of Multiple Sparse Representation and Statistical Property for SAR Target Configuration Recognition

Due to the characteristic of the synthetic aperture radar (SAR) image's sensitivity to the target aspect angles, a multiple sparse representation (MSR) method for SAR target configuration recognition is proposed. Making use of the prior information, dictionaries are constructed by using the samples of each configuration to better capture the detail information of the SAR images. The advantage of MSR over sparse representation for detail feature extraction is analyzed. Moreover, to achieve better recognition results, the Dempster-Shafer fusion is carried out to get comprehensive description of the target for configuration recognition. Two mass functions are constructed based on MSR and the sample statistical property. The combined mass function has the advantages of both the detail and global features of the target. Experiments on the moving and stationary target acquisition and recognition data sets validate the effectiveness and superiority of the proposed algorithm.
Design Optimization of Waveguide Bends in Photonic Crystals

In this paper, a fast and robust optimization scheme is presented and applied to the optimal design of planar photonic crystals. It is based on a parallel hybrid (stochastic-deterministic) algorithm coupled to a semi-analytic solution of ldquofull Maxwellrdquo equations by multiple scattering technique. The numerical results of the optimal design of different waveguide bends are presented.
Isolation and Identification of an Epibiotic Bacterium Associated with Heterocystous Anabaena Cells

Heterotrophic bacteria are commonly found in close associations with photosynthetic cyanobacteria in aquatic ecosystems. Some of these associations can be speciesspecific and mutualistic, resulting in optimal growth and nitrogen-fixing potential for the cyanobacteria. A two-membered culture, consisting of a heterotrophic, epibiotic bacterium attached to an Anabaena sp. was studied in the work reported here. The epibiotic bacterium was grown in pure culture, and both organisms were identified on the basis of their 16S rRNA gene sequence. The specificity of the epibiont for the Anabaena sp. heterocysts was confirmed by re-association experiments. The epibiont is a member of the Alphaproteobacteria in the order Rhizobiales, with close relatives that include a group of aerobic anoxygenic photosynthetic marine isolates commonly associated with dinoflagellate phytoplankton. The close association of the epibiotic bacterium with its Anabaena host, and its phylogenic affiliation allude to the evolutionary history of association with photosynthetic organisms for a group of Rhizobia and warrant further investigation. In diverse aquatic environments, bacteria routinely form close associations with photosynthetic cyanobacteria (1). These cyanobacteria represent a favorable habitat for heterotrophic bacteria because of their buoyancy, production of a mucilaginous sheath, and excretion of copious organic carbon and nitrogen compounds (2– 4). Some epibiotic bacteria exhibit specificity for their cyanobacterial hosts through chemotaxis and specificity for the site of their attachment (5–7). These relationships are mutualistic: for example, epibiotic cells incorporate fixed organic carbon and nitrogen from the cyanobacterium Anabaena within an hour under optimal conditions (8). Aerobic respiration of
Diethyl 3,3′-(phenylmethylene)bis(1H-indole-2-carboxylate)

In the title compound, C29H26N2O4, the benzene ring is twisted by 73.5 (5) and 84.9 (3)° with respect to the mean planes of the two indole ring systems; the mean planes of the indole ring systems are oriented at a dihedral angle of 82.0 (5)°. In the crystal, molecules are linked by pairs of N—H⋯O hydrogen bonds into chains.
Segmentation of Sinusoids in Hematoxylin and Eosin Stained Liver Specimens Using an Orientation-Selective Filter

The liver comprises cell layers of hepatocytes called trabeculae, which are separated by vascular sinusoids. Under- standing the structure of hepatic trabeculae and liver sinusoids in hematoxylin and eosin (HE)-stained liver specimens is important for the differential diagnosis of liver diseases. In this study, we develop an approach to extracting liver sinusoids from HE-stained images. The proposed approach involves: 1) a new orientation-selective filter (OS filter) for edge enhancement and image denoising, 2) the clustering of image pixels to identify candidate sinusoids, and 3) a classification procedure that discards unlikely candidates and selects the final sinusoid areas. Experimental studies using a database of 16 images with a resolution of 512 × 512 pixels showed that the proposed approach could segment liver sinusoid pixels with 81% of specificity and 94% of sensitivity. A comparison with a method based on bilateral filters showed that this method improved the sensitivity for all images with an average improvement of 4% and no difference in specificity. The results were presented to a group of pathologists and they confirmed that the images were highly representative of the tissue morphology features.
Hybrid Edge Detector

In this paper a hybrid edge detection algorithm has been envisaged. Real Images are often corrupted by noise from various sources. The classical edge detectors fail to give adequate intelligence of edges for images with depleted signal to noise ratio (SNR). A major dilemma in edge-detection for noisy images is the choice of optimum threshold which lacks generality. The dominance of noise in image reflects false edges in spatial domain. Addressing this dilemma, this paper presents a methodology and a framework in which smoothing effects of wavelet filters have been exploited prior to classical operators. Experimental results indicate that the hybrid edge detector gives qualitative and quantitative results comparable to Canny (1986), while it is simpler to implement.
Naval Architecture Applied to the Reconstruction of an Early XVII Century Portuguese

The Portuguese sailed yearly on the India Route during over two centuries, between the early XVI century and the XVIII century. Most ships employed in this route belonged to the Nau type and were among the largest and strongest ships of their time. Although extremely interesting, there is presently very little knowledge about the technical characteristics of these ships. The reason is that they were built in a pre-industrial era when technical design and documentation procedures almost did not exist. The method that is presently being applied by the authors to investigate the technical characteristics of these ancient ships combines the analysis of archaeological remains, the interpretation of contemporary texts on shipbuilding and modern Naval Architecture techniques. The paper starts by describing the ship wreck discovered recently at the mouth of the Tagus River, known as the Pepper Wreck, which was identified as the Portuguese ship Nossa Senhora dos Mártires, lost in this place on its return voyage from Cochim, in India, on September 14, 1606. This is the first significant ship wreck of a Portuguese Nau comprehensively excavated and analyzed by Nautical Archeologists and in fact the resulting data made possible the study presented here. Based on the analysis of the archaeological remains and on contemporary texts, including Portuguese shipbuilding treatises, a reconstruction of the lines plan and rigging is proposed, as well as the lightweight and cargo distribution on board. The cargo spaces resulting from the reconstruction of the hull are evaluated using ancient tonnage measurement techniques and modern Naval Architecture techniques to evaluate the cargo capacity of the ship. The intact floatability and stability of the ship are also investigated and compared with a modern stability criterion appropriate for large sailing vessels.
THE IMPACT OF DUST EVOLUTION AND PHOTOEVAPORATION ON DISK DISPERSAL

Protoplanetary disks are dispersed by viscous evolution and photoevaporation in a few million years; in the interim small, sub-micron-sized dust grains must grow and form planets. The time-varying abundance of small grains in an evolving disk directly affects gas heating by far-ultraviolet (FUV) photons, while dust evolution affects photoevaporation by changing the disk opacity and resulting penetration of FUV photons in the disk. Photoevaporative flows, in turn, selectively carry small dust grains, leaving the larger particles—which decouple, from the gas—behind in the disk. We study these effects by investigating the evolution of a disk subject to viscosity, photoevaporation by EUV, FUV, and X-rays, dust evolution, and radial drift using a one-dimensional (1D) multi-fluid approach (gas + different dust grain sizes) to solve for the evolving surface density distributions. The 1D evolution is augmented by 1+1D models constructed at each epoch to obtain the instantaneous disk structure and determine photoevaporation rates. The implementation of a dust coagulation/fragmentation model results in a marginal decrease in disk lifetimes when compared to models with no dust evolution; the disk lifetime is thus found to be relatively insensitive to the evolving dust opacity. We find that photoevaporation can cause significant reductions in the gas/dust mass ratio in the planet-forming regions of the disk as it evolves, and may result in a corresponding increase in heavy element abundances relative to hydrogen. We discuss implications for theories of planetesimal formation and giant planet formation, including the formation of gas-poor giants. After gas disk dispersal, ∼ 3 × 10 − 4 ? > M ⊙ ? > of mass in solids typically remain, comparable to the solids inventory of our solar system.
Acute Graft‐versus‐Host Disease: Clinical Characteristics in the Cyclosporine Era

Graft-versus-host disease (GVHD) remains the major problem in allogeneic bone marrow transplantation. GVHD has limited the use of this technique to HLA-matched donor recipient pairs. Thus, only a quarter of patients who ultimately may have benefited from bone marrow transplantation are currently eligible. Even in matched patient recipient pairs, GVHD accounts for approximately 40% of the deaths following allogeneic bone marrow transplants. One of the major challenges for transplantation is to derive better strategies to prevent and treat GVHD while retaining the allogeneic benefit of graft-versus-leukemia. Current pharmacologic approaches have used cyclosporine, usually in combination with other drugs. More experimental approaches have removed lymphocytes from the marrow grafts. With either approach, maintaining the anti-leukemic benefit of an allogeneic transplant (i.e., immunologic attack of the leukemia resulting in a lower relapse rate), will need to be maintained if that approach will ultimately prove to be useful.
Immobilization of streptavidin-horseradish peroxidase onto a biotinylated poly(acrylic acid) backbone that had been radiation-grafted to a PTFE film

Films of polytetrafluoroethylene (PTFE) were modified by radiation graft polymerization of acrylic acid (AAc). Optimal conditions for efficient AAc grafting were studied, including pre-irradiation dose in air, monomer concentration, temperature and time of the grafting process. Carboxylic groups of the grafted polyAAc were activated with carbodiimide (EDC) for biotinylation by reaction with 5-(biotinamido) pentylamine. Streptavidin-horseradish peroxidase (SA-HRP) was immobilized by affinity complexation of the SA with the biotin groups on the PTFE surface. The amount of active HRP immobilized on the PTFE films was determined as a function of the extent of polyAAc grafting. This study has demonstrated the utility of combining the processes of (a) radiation grafting of polymers with reactive groups onto inert polymers such as PTFE, (b) biotinylation of the graft polymer reactive groups, (c) immobilization of streptavidin on the biotinylated surface sites, followed by (d) immobilization of biotinylated, biologically active molecules via complexation of their conjugates with streptavidin. In this study, the last two steps were combined by immobilizing the complex of streptavidin and biotinylated HRP onto the biotinylated surface sites. The unique nature of this process is the ability to immobilize biotinylated molecules on an inert surface as PTFE.
Manganese homeostasis and utilization in pathogenic bacteria

Manganese (Mn) is a required cofactor for all forms of life. Given the importance of Mn to bacteria, the host has devised strategies to sequester Mn from invaders. In the macrophage phagosome, NRAMP1 removes Mn and other essential metals to starve intracellular pathogens; in the extracellular space, calprotectin chelates Mn and Zn. Calprotectin‐mediated Mn sequestration is a newly appreciated host defense mechanism, and recent findings are highlighted herein. In order to acquire Mn when extracellular concentrations are low, bacteria have evolved efficient Mn acquisition systems that are under elegant transcriptional control. To counteract Mn overload, some bacteria possess Mn‐specific export systems that are important in vivo, presumably for control of intracellular Mn levels. Mn transporters, their transcriptional regulators and some Mn‐requiring enzymes are necessary for virulence of certain bacterial pathogens, as revealed by animal models of infection. Furthermore, Mn is an important facet of the cellular response to oxidative stress, a host antibacterial strategy. The battle for Mn between host and pathogen is now appreciated to be a major determinant of the outcome of infection. In this MicroReview, the contribution of Mn to the host–pathogen interaction is reviewed, and key questions are proposed for future study.
Mass spectrometric peptide analysis of 2DE‐separated mouse spinal cord and rat hippocampus proteins suggests an NGxG motif of importance for in vivo deamidation

Asparagine deamidation is a common nonenzymatic post‐translational modification comprising the conversion of asparaginyl residues to aspartyl and isoaspartyl residues, respectively. As a result an additional negative charge is introduced that can affect the tertiary structure as well as the biological activity of a protein. Since deamidation reduces the protein's pI value, differentially deamidated forms of a protein can be separated in 2D gels. We have analyzed a dataset of 430 protein spots from 2D gels that contained mouse spinal cord proteins and estimated that roughly 10% of the spots in a Coomassie‐stained gel derive from in vivo deamidation at particular asparaginyl residues. Several of the deamidated protein forms, e.g. tropomodulin‐2, V‐type proton ATPase subunit B, and protein disulfide‐isomerase A3 were also found in 2D gels of proteins extracted from rat hippocampus. All identified deamidation sites contained a glycine residue on the carboxyl side of the asparaginyl residue. Strikingly, a second glycine residue at the +3 position was found in the majority of the deamidated peptides. We propose that the NGxG motif confers exceptional susceptibility to in vivo asparagine deamidation.
Recorded food intake of obese women with binge eating disorder before and after weight loss.

Because binge eating in obese individuals has been postulated to be a reaction to dietary restriction, we examined the recorded food intake of 17 obese women with and 16 obese women without binge eating disorder (BED) during 1-week periods before and 3 months after a very low calorie diet program in order to determine the effects of dietary restriction on binge eating frequency and severity. Before weight loss, rather than reporting severe caloric restriction, women with BED reported greater average energy intake than nonbinge eaters on both a total (2707 vs. 1869 k cal/day, p < .01) and weight-adjusted (25.1 vs. 18.1 kcal/kg, p < .01) basis, with both higher intake on nonbinge days and an increased frequency of binge days. After weight loss, there was no significant difference in energy intake, on either a total or weight-adjusted basis, between subjects with and without BED. Although average daily energy intake fell for both groups after weight loss, only subjects with BED reported significantly decreased energy intake when adjusted for change in body weight. This resulted from decreased intake on nonbinge days and a decreased frequency of binge days. Before weight loss, subjects with BED reported an average energy intake equivalent to 94% of their predicted energy expenditure. Whereas subjects without BED reported intake only 64% of predicted (p = .002). After weight loss, there was no significant difference between subjects with and without BED in the percentage of predicted energy expenditure reported as intake (64% vs. 58%). Restraint was similar in both groups before weight loss, but those with BED reported greater hunger and disinhibition. After weight loss treatment, restraint increased significantly, whereas disinhibition and hunger remained elevated in subjects with BED. Disinhibition, rather than restraint, appears to be a major contributor to the disordered eating of these individuals. Unlike normal-weight women with bulimia nervosa, dietary restriction does not appear to worsen symptoms of binge eating in obese women with BED. Over the short term, subjects with BED may respond to a standard weight loss treatment program with improvements in binge eating behaviors.