Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative performance Analysis of the Machine Intelligent Quotient ( MIQ ) and Human – Machine Cooperative Systems

This paper presents results of investigation into the development of a measurement of the machine intelligent quotient (MIQ) criterion. This scheme has been devised as an alternative to the traditional human to human natural way of conducting a survey type search. Information in control engineering education awareness results (data) is stored in the computer for ease of retrieval as and when necessary. A plethora of existing intelligence-based modelling and control strategies biased towards cybernetic techniques such as forecasting, prediction and training have been utilised for the purposes of identification, modelling, simulation, analysing and evaluation. A comparison of traditional search approaches and the new improved cybernetic search technique has shown that the improved technique has yielded better results. The cybernetic balance search method can be automated. Past and current data can be retrieved and future trend of data be predicted at the touch of a button, and the results have shown that, when optimally formulated, performance of the cybernetic system can be enhanced, either by explicit optimisation methods or extensive computation. This research will help researchers to asses intelligent machines that are designed to perform human-like qualities with a high degree of autonomy.
Pharmacodynamics of Vildagliptin in Patients With Type 2 Diabetes During OGTT

This randomized, open‐label, placebo‐controlled, 7‐period crossover study assessed dose‐response relationships following single oral doses (10–400 mg) of vildagliptin in 16 patients with type 2 diabetes mellitus. Plasma levels of parent drug, dipeptidyl peptidase‐4 activity, glucose, insulin, and glucagon were measured during 75‐g oral glucose tolerance tests performed after an overnight fast, 30 minutes after drug administration. The tmax for parent drug was observed between 0.5 and 1.5 hours postdose. Both Cmax and AUC0–8 h increased dose proportionately. Both onset and duration of dipeptidyl peptidase‐4 inhibition were dose dependent, but >90% inhibition occurred within 45 minutes and was maintained for ≥4 hours after each dose. Glucose excursions and glucagon levels during oral glucose tolerance tests were significantly and similarly decreased after each dose of vildagliptin, and insulin levels were significantly and similarly increased after each dose level. Unlike findings during mixed‐meal challenges, vildagliptin increases plasma insulin levels during oral glucose tolerance tests in patients with type 2 diabetes mellitus.
Internal Dynamics of ABCG 209 at z ~ 0.21

We report the results about the internal dynamics of the rich galaxy cluster ABGC 209 on the basis of new spectroscopic and photometric data. ABCG209 is a peak of 112 detected member galaxies at z= 0.209, characterised by a high value of the line–of–sight velocity dispersion, σv ∼ 1400 km s−1. The cluster shows evidence of relevant substructure and dynamical segregation, and is characterised by a preferential SE–NW direction. The observational scenario suggests that ABCG209 is a strongly evolving cluster, possibly in an advanced phase of merging.
The influence of age on propofol pharmacodynamics.

BACKGROUND The authors studied the influence of age on the pharmacodynamics of propofol, including characterization of the relation between plasma concentration and the time course of drug effect. METHODS The authors evaluated healthy volunteers aged 25-81 yr. A bolus dose (2 mg/kg or 1 mg/kg in persons older than 65 yr) and an infusion (25, 50, 100, or 200 microg x kg(-1) x min(-1)) of the older or the new (containing EDTA) formulation of propofol were given on each of two different study days. The propofol concentration was determined in frequent arterial samples. The electroencephalogram (EEG) was used to measure drug effect. A statistical technique called semilinear canonical correlation was used to select components of the EEG power spectrum that correlated optimally with the effect-site concentration. The effect-site concentration was related to drug effect with a biphasic pharmacodynamic model. The plasma effect-site equilibration rate constant was estimated parametrically. Estimates of this rate constant were validated by comparing the predicted time of peak effect with the time of peak EEG effect. The probability of being asleep, as a function of age, was determined from steady state concentrations after 60 min of propofol infusion. RESULTS Twenty-four volunteers completed the study. Three parameters of the biphasic pharmacodynamic model were correlated linearly with age. The plasma effect-site equilibration rate constant was 0.456 min(-1). The predicted time to peak effect after bolus injection ranging was 1.7 min. The time to peak effect assessed visually was 1.6 min (range, 1-2.4 min). The steady state observations showed increasing sensitivity to propofol in elderly patients, with C50 values for loss of consciousness of 2.35, 1.8, and 1.25 microg/ml in volunteers who were 25, 50, and 75 yr old, respectively. CONCLUSIONS Semilinear canonical correlation defined a new measure of propofol effect on the EEG, the canonical univariate parameter for propofol. Using this parameter, propofol plasma effect-site equilibration is faster than previously reported. This fast onset was confirmed by inspection of the EEG data. Elderly patients are more sensitive to the hypnotic and EEG effects of propofol than are younger persons.
Comparison of the calcaneal pitch angle and modified projection area per length squared method for medial longitudinal arch evaluation of the foot.

OBJECTIVE To compare the calcaneal pitch angle (CPA) values measured on direct lateral radiographs of feet, and the modified projection area per length squared (PAL), which was calculated as a new method for the evaluation of the medial longitudinal arch (MLA) of the foot. MATERIAL AND METHODS Direct lateral radiographs of patients who had weightbearing feet radiographies for any reason except trauma were retrospectively obtained from the archives. Direct lateral radiographs of the feet were printed and a transparent sheet was placed on it. A straight line was drawn between the most plantar process of the calcaneus and the head of the first metatarsal bone for the calculation of the PAL of the MLA. Two semilunar arcs were drawn upon this straight line. PAL1 and PAL2 were estimated using a point-counting technique. The CPA, lateral talo-calcaneal angles (LTCA), and talo-first metatarsal angles (TFMA) were measured. The correlations between PAL1, PAL2 of right and left feet and CPA, LTCA, and TFMA were explored. RESULTS Fifty patients (27 females, 23 males) with a mean age of 40.12 (4-78) years were evaluated. Significant correlations were detected between PAL1, PAL2 and CPA, and TFMA for both right and left feet (p<0.05). CONCLUSION A significant correlation was detected between the modified PAL method as a new technique and the standard CPA method for MLA evaluation. The PAL method is suggested as a simple and practical method for MLA evaluation.
Optimal Synthesis of Directivity Constrained Pencil Beams by Means of Circularly Symmetric Aperture Fields

The problem of the optimal synthesis of circularly symmetric aperture distributions able to radiate pencil beams fulfilling well-defined requirements on the far-field and/or the directivity is addressed and solved. In particular, constraints concerning both the sidelobe level (SLL) and the directivity within a coverage zone are dealt with while being careful not to incur into the so called super-directive sources or into aperture fields actually difficult to be realized. The case wherein a constraint is enforced on the dynamics of the excitations is also considered. Numerical examples concerning cases of practical relevance are also shown in support to the given theory.
Prediction of Heart Disease using Data Mining Techniques

Data mining is process to analyses number of data sets and then extracts the meaning of data. It helps to predict the patterns and future trends, allowing business in decision making. Data mining applications are able to give the answer of business questions which can take much time to resolve traditionally. High amount of data that can be generated for the prediction of disease is analyzed traditionally and is too complicated along with voluminous to be processed. Data mining provides methods and techniques for transformation of the data into useful information for decision making. These techniques can make process fast and take less time to predict the heart disease with more accuracy. The healthcare sector assembles enormous quantity of healthcare data which cannot be mined to uncover hidden information for effectual decision making. However, there is a plenty of hidden information in this data which is untapped and not being used appropriately for predictions. It becomes more influential in case of heart disease that is considered as the predominant reason behind death all over the world. In medical field, Data Mining provides several methods which are widely used in the medical and clinical decision support systems which should be helpful for diagnosis and predicting of various diseases. These data mining techniques can be used in heart diseases takes less time and make the process much faster for the prediction system to predict diseases with good accuracy to improve their health. In this paper we survey different papers in which one or more algorithms of data mining used for the prediction of heart disease. By Applying data mining techniques to heart disease data which requires to be processed, we can get effective results and achieve reliable performance which will help in decision making in healthcare industry. It will help the medical practitioners to diagnose the disease in less time and predict probable complications well in advance. Identify the major risk factors of Heart Disease categorizing the risk factors in an order which causes damages to the heart such as diabetes, high blood cholesterol, obesity, hyper tension, smoking, poor diet, stress, etc. Data mining techniques and functions are used to identify the level of risk factors which helps the patients to take precautions in advance to save their life.
Radiographic Findings in Revision Anterior Cruciate Ligament Reconstructions from the MARS Cohort

Abstract The Multicenter ACL (anterior cruciate ligament) Revision Study (MARS) group was developed to investigate revision ACL reconstruction outcomes. An important part of this is obtaining and reviewing radiographic studies. The goal for this radiographic analysis is to establish radiographic findings for a large revision ACL cohort to allow comparison with future studies. The study was designed as a cohort study. Various established radiographic parameters were measured by three readers. These included sagittal and coronal femoral and tibial tunnel position, joint space narrowing, and leg alignment. Inter- and intraobserver comparisons were performed. Femoral sagittal position demonstrated 42% were more than 40% anterior to the posterior cortex. On the sagittal tibia tunnel position, 49% demonstrated some impingement on full-extension lateral radiographs. Limb alignment averaged 43% medial to the medial edge of the tibial plateau. On the Rosenberg view (45-degree flexion view), the minimum joint space in the medial compartment averaged 106% of the opposite knee, but it ranged down to a minimum of 4.6%. Lateral compartment narrowing at its minimum on the Rosenberg view averaged 91.2% of the opposite knee, but it ranged down to a minimum of 0.0%. On the coronal view, verticality as measured by the angle from the center of the tibial tunnel aperture to the center of the femoral tunnel aperture measured 15.8 degree ± 6.9% from vertical. This study represents the radiographic findings in the largest revision ACL reconstruction series ever assembled. Findings were generally consistent with those previously demonstrated in the literature.
eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways

Messenger RNA translation, or protein synthesis, is a fundamental biological process affecting cell growth, survival and proliferation. Initiation is the rate limiting and hence the most regulated step of translation. In eukaryotes, translation initiation is facilitated by multiple protein factors collectively called eIFs (for eukaryotic translation initiation factors). The complex consisting of the eIF4 group factors including the mRNA cap-binding eIF4E protein, large scaffolding protein eIF4G and RNA helicase eIF4A is assisted by the eIF4B co-factor to unwind local secondary structures and create a ribosome landing pad on mRNA. Recruitment of the ribosome and augmentation in the mRNA scanning process culminates in the positioning of the ribosome over the start codon. Deregulated translational control is believed to play an important role in oncogenic transformation. Indeed, many eIFs are bona fide proto-oncogenes. In many types of human cancers, eIFs are either overexpressed or ectopically activated by Ras-MAPK and PI3K-mTOR signaling cascades, resulting in increased survival and accelerated proliferation. In this review we will analyze the bulk of data describing eIF4B and its role in cell survival and proliferation. Recent studies have shown that eIF4B is phosphorylated and activated by Ras-MAPK and PI3K-mTOR signaling cascades. In addition, eIF4B regulates translation of proliferative and pro-survival mRNAs. Moreover, eIF4B depletion in cancer cells attenuates proliferation, sensitizes them to genotoxic stress driven apoptosis. Taken together, these findings identify eIF4B as a potential target for development of anti-cancer therapies.
Preventing Parental Child Abduction: Analysis of a National Project

Recent data from a study indicate that child abduction by a parent is up to six times more frequent than previous estimates had suggested. Relative to parental child abductions, stranger abductions occur on a very infrequent basis. While much attention has been placed on prevention programs for stranger abductions, prevention programs for parental child abduction have been nonexistent. The present study analyzes data from a national hotline program that targeted prevention of parental child abduction. Data were collected on 86 consecutive telephone calls from parents contemplating abduction of their child(ren). These data provide information on demographic variables, level of interparental conflict/violence, reasons for contemplating abduction, and abduction plans. Data are also presented that indicate a mediation program may be effective in preventing some cases of parental child abduction. However, such a mediation program is a very difficult course of action and impacts only a small percentage of parental child abduction cases.
Multiband non-resonant antenna system with reduced ground clearance

Small and multiband antennas are crucial elements for wireless devices. On one hand, the space devoted to the antenna is small due to the presence of other electronic components in the device. On the other hand, the number of frequency bands with the inclusion of 4G is relevant. In order to achieve a small and multiband antenna, a strategy using a non-resonant element in combination with a passive multiband matching network is proposed. Also, in order to facilitate the integration of other electronic components in the device, the ground clearance is reduced and its impact on efficiency has been evaluated. The feasibility of the proposal is analyzed both in the simulation domain as well as with a prototype to validate the results. The proposed architecture comprises a non-resonant element of 12 mm × 3 mm × 2.4 mm (h) operating at 824MHz-960MHz and 1710MHz-2690MHz with a ground clearance of 20 mm × 11 mm suitable for smartphones.
A new flavellagic acid derivative and phloroglucinol from Rhodomyrtus tomentosa

A new flavellagic acid derivative, 3,3′,4,4′-tetra-O-methylflavellagic acid and six known compounds were isolated from the stems of Rhodomyrtus tomentosa while a new phloroglucinol, named rhodomyrtosone I, and six known compounds were isolated from the fruit. Their structures were elucidated by spectroscopic analyses as well as by comparisons with related compounds.
CARD10 Is a Novel Caspase Recruitment Domain/Membrane-associated Guanylate Kinase Family Member That Interacts with BCL10 and Activates NF-κB*

BCL10 belongs to the caspase recruitment domain (CARD) family of proteins that regulate apoptosis and NF-κB signaling pathways. Analysis of BCL10-deficient mice has revealed that BCL10 mediates NF-κB activation by antigen receptors in B and T cells. We recently identified a subclass of CARD proteins (CARD9, CARD11, and CARD14) that may function to connect BCL10 to multiple upstream signaling pathways. We report here that CARD10 is a novel BCL10 interactor that belongs to the membrane-associated guanylate kinase family, a class of proteins that function to organize signaling complexes at plasma membranes. When expressed in cells, CARD10 binds to BCL10 and signals the activation of NF-κB through its N-terminal effector CARD domain. We propose that CARD10 functions as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-κB.
Geometrical Blind Separation of Sources Based in a Discrete-Lattice of the Space of Observations

The techniques of Blind Separation of Sources (BSS) are used in many Signal Processing applications in which the data sampled by sensors are a mixture of signals from different sources, and the goal is to obtain an estimation of the sources from the mixtures. This work shows a new method for blind separation of sources, based on geometrical considerations concerning the observation space. This new method is applied to a mixture of two sources and it obtains the coefficients of the unknown mixture matrix A and separates the unknown sources, So. Following an introduction, we present a brief abstract of previous work by other authors, the principles of the method and a description of the algorithm, together with some simula tions.
Tenderisation of spent hen meat using ginger extract

Abstract 1. The purpose of this work was to study the effect of ginger extract (GE) on tenderness of spent hen meat. 2. Spent hen meat chunks at either the pre- or post-chilled stage were marinated with different concentrations (0%, 1%, 3% and 5% v/w) of GE and were evaluated after 24 h of treatment. 3. GE treatment increased the pH, moisture, cooking yield, total pigments, water holding capacity, collagen solubility, protein extractability, muscle fibre diameter and decreased the shear force values. 4. The electrophoretic pattern of muscle proteins revealed extensive proteolysis and reduction in number of protein bands in GE treated samples. 5. Tenderness scores were higher in samples treated at post-chilled stage. Of the different concentrations of GE examined, 3% was found optimum for tenderisation.
Vaccination of cows with a K99 extract to protect newborn calves against experimental enterotoxic colibacillosis

Pregnant cows and heifers were vaccinated with a crude K99 extract prepared from an Escherichia coli K-12, K99 strain. A similar group, injected with an extract prepared from the K-12 parent strain, served as a control. Eleven calves were born to both groups and challenged orally with a mean of 1.6 x 10(11) bacteria of enterotoxic E. coli B41 (O101:K99+, ST+) at the time of first colostrum uptake (1 to 7 h after birth). As a result of challenge, no death occurred in the vaccine group, but four calves died in the control group. Six calves in the vaccine group and all calves in the control group developed diarrhea. Colostral anti-O101 titers were very similar in both groups. Anti-K99 titers of colostral samples from the vaccinated dams were, however, significantly higher as compared to those of the controls. It is suggested that colostral antibodies, raised against the crude K99 extract vaccine, exerted a protective effect on newborn calves against the challenge enterotoxigenic E. coli O101:K99+, Ent+ strain.
Small Dense Low-Density Lipoproteins and Associated Risk Factors in Patients with Stroke

Objective: Low-density lipoproteins (LDL) are a heterogeneous group of particles, with small, dense particles being more atherogenic. It remains controversial whether elevated plasma levels of small dense LDL (sd-LDL) are risk factors for stroke. The aim of the present study was to examine the plasma levels of sd-LDL in patients with stroke and to investigate the associations in a large Chinese case-control study. Methods: We recruited 299 stroke patients (159 cerebral thrombosis, 42 lacunar infarction, 98 intracerebral hemorrhage) and 299 controls. The semiquantitative analysis of plasma levels of sd-LDL was performed by nondenaturing gradient gel electrophoresis. Results: (1) The plasma levels of sd-LDL in patients with ischemic stroke or hemorrhagic stroke were higher than in controls. (2) Multiple regression analysis showed that there were significant relationships between sd-LDL and triglyceride, high-density lipoprotein cholesterol, LDL cholesterol, systolic blood pressure and history of diabetes, and a significant relationship between sd-LDL and stroke (r = 0.286, p < 0.001) even after adjusting for these factors. (3) Compared with the controls, the calculation of odds ratios indicated relative risk estimates of 3.111 for ischemic stroke (OR = 3.111 , 95% CI = 1.891–5.117, p < 0.001) and 3.164 for hemorrhagic stroke (OR = 3.164, 95% CI = 1.632–6.137, p < 0.01). Conclusion: Plasma sd-LDL was independently associated with both thrombotic and hemorrhagic stroke, suggesting it may be an independent predictor of as well as a risk factor for stroke in Chinese people, justifying clinical trials for primary and secondary prevention of stroke using statins or fibrates.
Symptom perception in pediatric asthma: relationship to functional morbidity and psychological factors.

OBJECTIVE Perception of changes in respiratory symptoms is a critical element in the self-management of pediatric asthma. The purpose of this study was to quantify perceptual accuracy in childhood asthma, to investigate links between symptom perception and functional morbidity, and to examine relationships between psychological variables and perceptual accuracy. METHOD Eighty-six children, aged 8 to 15 years, attending an asthma camp made subjective estimates of asthma severity immediately prior to spirometry an average of 31 times at camp. The correlation coefficient between these measures (the child's accuracy index) was analyzed in relation to morbidity data and to scores on instruments that assessed trait anxiety, repressive coping style, intelligence, behavior problems, and parental symptom-reporting patterns. RESULTS A wide range of perceptual ability was found, as children's subjective-objective r ranged from-. 39 to . 88. Greater perceptual accuracy was significantly related to fewer days missed from school and fewer emergency medical visits. Of the psychological variables assessed, only intelligence was significantly related to accuracy. CONCLUSIONS Symptom perceptual ability is an important psychosomatic factor affecting the course of asthma for some children. Further study is indicated to understand psychological variables in addition to intelligence that may determine a child's perceptual accuracy.