Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti-Exodus: Countermemory, Gender, Race, and Everyday Life in Toni Morrison's Paradise

This article examines the critique of communal politics of life in Paradise focusing upon the two tropes through which Morrison dramatizes the frictions of such politics. On the one hand, she re-invokes the Exodus-trope of African American national politics for her critique of Ruby's racist and patriarchal "covenant of life. " On the other hand, she puts forward an Anti-Exodus trope through which, in her sections on the Convent women's practice of everyday life, Patricia Best's use of countermemory, and Piedade's songs, she explores some of the possibilities and risks of a cross-racial, women-centered, and transnational politics of life.
EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity

Tumor metastasis is a multistep process that requires the concerted activity of discrete biological functions. The epithelial-to-mesenchymal transition (EMT) is the most critical mechanism implicated in tumor progression that is controlled by the inflammatory microenvironment. Understanding how an inflammatory microenvironment is maintained and contributes to tumor progression will be crucial for the development of new effective therapies. Here, we report that etoposide induced 2.4 (EI24) has a multifaceted role against tumor progression that is regulated by both EMT and inflammation. Decreased expression levels of EI24 in epithelial tumor cells induced EMT in association with increased cell motility and invasiveness and resistance to anoikis. Overexpression of EI24 resulted in the opposite cell biological characteristics and suppressed in vivo metastatic behavior. EI24 attenuated NF-κB activity by binding to the Complex I component TRAF2 and inducing its lysosome-dependent degradation, leading to transcriptional alterations of EMT-and inflammation-related genes. Analysis of clinical samples demonstrated that reduced EI24 expression and copy number was positively correlated with tumor malignancy and poor prognosis. Collectively, these findings establish EI24 as a critical suppressor of tumor progression and implicate EI24 expression level in malignant tumors as a useful therapeutic and diagnostic marker.
Imitation of High-Interest Comic Strip Models' Appropriate Classroom Behavior: Acquisition and Generalization.

Animated cartoons depicting aggressive behavior have been used widely in the investigation of reinforced and generalized imitation in the laboratory. Little research has examined the use of either animated or comic strip cartoons in the teaching and encouragement or desirable skills and activities in real-life settings. The present study employed comic strip drawings of high-interest cartoon models to symbolize and teach skills contributing to the social and educational development of children in a child care center. The results demonstrate that high-interest cartoon models are both effective and feasible agents for positive behavioral change when used within the generalized imitation framework. In addition, four alternative explanations of generalized imitation were tested: the failure to discriminate explanation, the variable-ratio schedule explanation, the demand characteristics explanation and the reinforcement value of stimulus similarity explanation. The findings contradicted the first three and off.
NRG1‐ErbB signalling promotes microglia activation contributing to incision‐induced mechanical allodynia

Spinal microglia activation is one of the pathologic mechanisms involved in post‐operative pain, which results from surgical injuries in skin, fascia, muscle and small nerves innervating these tissues. Recent research has shown that neuregulin‐1 (NRG1) and its receptor erythroblastosis oncogene B (ErbB) family mediate microglia proliferation and chemotaxis contributing to the development of neuropathic pain. However, it is unclear whether NRG1‐ErbB signalling contributes to incision‐induced mechanical allodynia.
Concept-based Semantic Search over Encrypted Cloud Data

Cloud computing is a technology that allows companies and individuals to outsource their data and their applications. The aim is to take advantage from the power of storage and processing offered by such technology. However, in order to preserve data privacy, it is crucial that all data must be encrypted before being outsourced into the cloud. Moreover, authorized users should be able to recover their outsourced data. This process can be complicated due to the fact that data are encrypted. The traditional information retrieval systems only work over data in the clear. Therefore, dedicated information retrieval systems were developed to deal with the encrypted cloud data. Several kinds of search over cloud data have been proposed in the literature such as Boolean search, multi-keyword ranked search and fuzzy search. However, the semantic search is little addressed in the literature. In this paper, we propose an approach called SSE-S that take into account the semantic search in the cloud by using Wikipedia ontology to understand the meaning of documents and queries with maintaining the security and the privacy issues.
Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium–Sensing Receptor

Background Monocrotaline has been widely used to establish an animal model of pulmonary hypertension. The molecular target underlying monocrotaline‐induced pulmonary artery endothelial injury and pulmonary hypertension remains unknown. The extracellular calcium–sensing receptor (CaSR) and particularly its extracellular domain hold the potential structural basis for monocrotaline to bind. This study aimed to reveal whether monocrotaline induces pulmonary hypertension by targeting the CaSR. Methods and Results Nuclear magnetic resonance screening through WaterLOGSY (water ligand‐observed gradient spectroscopy) and saturation transfer difference on protein preparation demonstrated the binding of monocrotaline to the CaSR. Immunocytochemical staining showed colocalization of monocrotaline with the CaSR in cultured pulmonary artery endothelial cells. Cellular thermal shift assay further verified the binding of monocrotaline to the CaSR in pulmonary arteries from monocrotaline‐injected rats. Monocrotaline enhanced the assembly of CaSR, triggered the mobilization of calcium signaling, and damaged pulmonary artery endothelial cells in a CaSR‐dependent manner. Finally, monocrotaline‐induced pulmonary hypertension in rats was significantly attenuated or abolished by the inhibitor, the general or lung knockdown or knockout of CaSR. Conclusions Monocrotaline aggregates on and activates the CaSR of pulmonary artery endothelial cells to trigger endothelial damage and, ultimately, induces pulmonary hypertension.
MAP estimation of speech spectral component under GGD a priori

This paper presents Maximum A Posteriori (MAP) estimation of the spectral components of clean speech from the observed data noised by the additive background noise having Gaussian or non-Gaussian statistical distribution. In the proposed algorithm MAP estimator for the spectral components of clean signal is derived using Generalized Gaussian Distribution (GGD) function as a priori statistical models for the spectral components of speech as well as noise. Since the spikiness of the GGD can be controlled by the shape parameter, it is possible to model Gaussian as well as non-Gaussian noise, corrupting the speech signal. The enhancement results for the speech signal corrupted by the Gaussian noise and nonGaussian noise are presented to show the usefulness of the estimator. Denoising performance for the Laplacian noise and white Gaussian noise have also been compared with that of the conventional Wiener filtering, which assumes Gaussian distributions for both the speech and noise.
Motor Planning in Chronic Upper-Limb Hemiparesis: Evidence from Movement-Related Potentials

Background Chronic hemiplegia is a common long-term consequence of stroke, and subsequent motor recovery is often incomplete. Neurophysiological studies have focused on motor execution deficits in relatively high functioning patients. Much less is known about the influence exerted by processes related to motor preparation, particularly in patients with poor motor recovery. Methodology/Principal Findings The current study investigates motor preparation using a modified response-priming experiment in a large sample of patients (n = 50) with moderate-to-severe chronic hemiparesis. The behavioural results revealed that hemiparetic patients had an increased response-priming effect compared to controls, but that their response times were markedly slower for both hands. Patients also demonstrated significantly enhanced midline late contingent negative variation (CNV) during paretic hand preparation, despite the absence of overall group differences when compared to controls. Furthermore, increased amplitude of the midline CNV correlated with a greater response-priming effect. We propose that these changes might reflect greater anticipated effort to respond in patients, and consequently that advance cueing of motor responses may be of benefit in these individuals. We further observed significantly reduced CNV amplitudes over the lesioned hemisphere in hemiparetic patients compared to controls during non-paretic hand preparation, preparation of both hands and no hand preparation. Two potential explanations for these CNV reductions are discussed: alterations in anticipatory attention or state changes in motor processing, for example an imbalance in inter-hemispheric inhibition. Conclusions/Significance Overall, this study provides evidence that movement preparation could play a crucial role in hemiparetic motor deficits, and that advance motor cueing may be of benefit in future therapeutic interventions. In addition, it demonstrates the importance of monitoring both the non-paretic and paretic hand after stroke and during therapeutic intervention.
Age differences in the retention of knowledge by young and elderly students

Nearly 400 former students aged between 25 and 77 were tested for retention of knowledge from an undergraduate degree course in cognitive psychology. Retention intervals ranged from three months to 12 years. Tests were designed to examine both recognition and recall of names and concepts; general and specific facts; conceptual relations and principles of experimental design. Retention interval and the grade originally achieved were found to be the most important predictors of retention. There was no age difference in the rate of forgetting. Small effects of age were apparent in memory for highly specific facts but memory for general facts, principles and conceptual relations was not significantly affected by age. The pattern of results suggests that general knowledge Schemas are age-resistant although lower-level specific knowledge is slightly age-impaired. Overall, the findings indicate that intelligent, highly motivated elderly people show very little deficit in the retention of formally acquired knowledge.
Modeling metamorphism in collisional orogens intruded by magmas: II. Fluid flow and implications for Barrovian and Buchan metamorphism, Scotland

This paper presents the results of two-dimensional numerical modeling of crustal fluid flow in a collisional overthrust setting during emplacement of syn-metamorphic mafic sills. An important feature of the fluid flow in the presence of magmatic intrusions is the long-lived prograde up-temperature (up-T) flow of fluid. This upward flow is driven by dehydration reactions in the rocks underlying the intrusions and upward is the consequence of the inverted thermal profile that appears within the depth range of magmatism. If magma is intruded at mid-crustal depths following crustal collision, the up-T flow regime may persist for as much as 5 Myr. Such long-lived up-T fluid flow is not observed in models without magmatism. Strong retrograde reactions in rocks surrounding intrusions may give rise to downward up-temperature flow into the heated but rapidly cooling areas of the crust during exhumation, but the fluid fluxes in these areas are typically small. The total time-integrated fluid fluxes produced by magmatism and crustal overthickening in the middle and deep crust are substantial, in some cases reaching 3,000 m3 m−2 over 35 Myr. Early magmatic events may give rise to fluid fluxes exceeding 1,000 m3 m−2 in only 1 Myr. The strong dehydration that accompanies the emplacement of hot magma into the relatively low-temperature wall rock leads to hydrofracturing of large volumes of crustal rocks surrounding intrusions. The fractured rock region may extend over tens of kilometers from the zone of magma emplacement. More hydrofracturing is predicted for the middle and deep crust than for the shallow crust because of the exponential decrease of crustal permeability with depth that is assumed in our models. Endothermic dehydration, exothermic retrograde hydration, and the latent heat of wall rock fusion can all influence thermal budgets. In the final part of the paper we integrate the results of the fluid flow modeling presented here, the reconstructions of thermal evolution presented in Part I, and field-based data for the type locality of Barrovian and Buchan metamorphism in Scotland. Many key phenomena predicted by our numerical models are observed in the Scottish Dalradian, including the very short thermal peaks attained over a relatively narrow time span across a broad range of metamorphic zones; penecontemporaneous Barrovian, Buchan, and granulite facies metamorphism; steep Metamorphic Field Temperature Gradients (MFTGs) in the vicinity of intrusions; and petrological evidence consistent with up-temperature fluid flow. Our results suggest that some controversial aspects of regional metamorphism in the Scottish Dalradian, including heat transfer processes and the steep MFTGs, may be plausibly explained by the effects of plutonism.
Pancreatic Cancer in HIV-Positive Patients: A Clinical Case-Control Study

Objectives Pancreatic cancer (PC) is the fourth and fifth most common cause of cancer-related death among men in United States and in Europe, respectively. No data are available for HIV-positive patients. The aim of this study was to investigate and to compare clinical presentation and outcome between HIV-positive and HIV-negative PC patients. Methods From April 1988 to June 2010, the Italian Cooperative Group on AIDS and Tumors identified 16 cases of HIV-positive PC patients. Each HIV-positive patient from our institution was randomly matched (ratio 1:2) with HIV-negative patients (32 controls) based on sex and year of PC diagnosis. Differences in clinical presentation, treatment, and overall survival were assessed. Results At multivariate analysis, HIV-positive patients compared with HIV-negative patients had a higher risk of an unfavorable performance status (PS ≥2) and a younger age (<50 years) at cancer diagnosis. At multivariate analysis, HIV-positive status and PS of 2 or greater were the only 2 features that significantly reduced PC patients’ survival. Conclusions Our data show, for the first time, that HIV-positive PC patients, compared with HIV-negative patients, are younger at cancer diagnosis. Furthermore, they share a more unfavorable PS and a shorter survival.
Teaching mindfulness-based cognitive therapy to trainee psychologists: Qualitative and quantitative effects

Mindfulness training has been related in previous research to reduced stress and increases in therapy-relevant characteristics, such as empathy, in health professionals. The present study investigated the experience of clinical psychology trainees as they completed mindfulness training and the impact it had on their stress and development as psychologists. Eleven trainee clinical psychologists completed the eight-week mindfulness-based cognitive therapy programme. Assessments were conducted prior to and following training, and again after two months, using semi-structured interviews and self-report measures of perceived stress, empathy and mindfulness. Thematic analysis of interview transcripts revealed four higher level themes: challenging experience; altered stress experience; altered therapy experience; and expanded knowledge. Statistically significant changes were found for one empathy sub-scale and three facets of a self-report mindfulness scale. Benefits developed through the mindfulness training were largely maintained, or developed further, over the two-month follow-up period. The impact of the course appeared to be influenced more by participants’ personal engagement with the training rather than amount of meditation practice. The implications for the training of psychologists are discussed.
Re-analysis of protein data reveals the germination pathway and up accumulation mechanism of cell wall hydrolases during the radicle protrusion step of seed germination in Podophyllum hexandrum- a high altitude plant

Podophyllum hexandrum Royle is an important high-altitude plant of Himalayas with immense medicinal value. Earlier, it was reported that the cell wall hydrolases were up accumulated during radicle protrusion step of Podophyllum seed germination. In the present study, Podophyllum seed Germination protein interaction Network (PGN) was constructed by using the differentially accumulated protein (DAP) data set of Podophyllum during the radicle protrusion step of seed germination, with reference to Arabidopsis protein–protein interaction network (AtPIN). The developed PGN is comprised of a giant cluster with 1028 proteins having 10,519 interactions and a few small clusters with relevant gene ontological signatures. In this analysis, a germination pathway related cluster which is also central to the topology and information dynamics of PGN was obtained with a set of 60 key proteins. Among these, eight proteins which are known to be involved in signaling, metabolism, protein modification, cell wall modification, and cell cycle regulation processes were found commonly highlighted in both the proteomic and interactome analysis. The systems-level analysis of PGN identified the key proteins involved in radicle protrusion step of seed germination in Podophyllum.
Research on gifted children and adolescents in Russia: A chronicle of theoretical and empirical development

During the time of the Soviet Union, Western experts did not receive detailed information about studies ofgiftedness in Russia. Since the 1960s, Russian psychologists have increasingly shared information about their studies of gifted children and adolescents with colleagues in Western countries. Krutetsky (1963, 1964) published reports that referred to special abilities. Matyushkin (1990) outlined a Soviet perspective on giftedness and creativity. Bogoyavlenskaya (1995a) compared creativity measured by the Torrance tests to an original technique that she developed for measuring creativity called Creative Field. Dorfman and Kovaleva (1996), and Dorfman, Kovaleva, and Kuz'mina (1997) reported on their study of creativity, measured by the Torrance tests, as moderator and mediator variables that affect the direction of or medh ate the relation between different personality characteristics. These recent studies are discussed below; however, they do not completely reflect the Russian literature on giftedness. In this article, the major goal is to present the history, methodology, and assessment of giftedness by Russian psychologists from the 1920s through the present.
Urban Street Grid Description and Verification Paper

While two-dimensional maps exist for most urban areas , the descriptions may be incomplete or out of date, or of insufficient resolution for the given application and features such a roads are not described as 3-D objects. Most of the past work on road detection has concentrated on either low resolution, primarily rural roads (usually producing " spaghetti " roads with no notion of intersections), high resolution road following without the topological information of the intersections, or pixel classification where there is no sense of the road as an object. This paper address the problem of extracting a street grid in an urban environment while maintaining the topological information of the intersections. Starting from an initial seed intersection, which gives the size and orientation of the expected grid, this system uses a feature-based hypothesis and verify paradigm to extract a 3-D description of the street grid. The verification uses the context provided by an intersection model and by an extended street model and other available sensors.
SEGMENT: identifying compositional domains in DNA sequences

MOTIVATION DNA sequences are formed by patches or domains of different nucleotide composition. In a few simple sequences, domains can simply be identified by eye; however, most DNA sequences show a complex compositional heterogeneity (fractal structure), which cannot be properly detected by current methods. Recently, a computationally efficient segmentation method to analyse such nonstationary sequence structures, based on the Jensen-Shannon entropic divergence, has been described. Specific algorithms implementing this method are now needed. RESULTS Here we describe a heuristic segmentation algorithm for DNA sequences, which was implemented on a Windows program (SEGMENT). The program divides a DNA sequence into compositionally homogeneous domains by iterating a local optimization procedure at a given statistical significance. Once a sequence is partitioned into domains, a global measure of sequence compositional complexity (SCC), accounting for both the sizes and compositional biases of all the domains in the sequence, is derived. SEGMENT computes SCC as a function of the significance level, which provides a multiscale view of sequence complexity.
Describing open distributed systems: a foundation

Outlines a semantic model for open distributed systems which provides a foundation for a corresponding architecture description language. This semantic model is based on architecture models reported by Berry et al. (1995) and in ISO/IEC 10746 (ODP), with a number of refinements to support abstraction and composition. The model is specifically designed to describe open distributed systems independent of implementation details such as communication protocols and middleware systems. The modelling concepts in the semantic model are: object (a model of an entity), event (a unit of interaction between an object and its environment), event relationship (a specification of behaviour defining the relationships amongst a set of events), interface (an abstraction of an object's interaction with its environment) and binding (a context for interaction between objects). The binding concept is particularly important because it can describe any kind of interaction in an open distributed system, ranging from remote procedure calls and multicasting to more complex, enterprise interactions. Special attention is given to the problem of composition and abstraction of events and behaviour in the model. This is needed to reflect the reuse, evolution and interworking requirements of open distributed systems. Our approach allows for the effective modelling of asynchrony, concurrency and complex flows of information in open distributed systems.