Miracle-dz/UniFAR-FTUs huggingface dataset:
Mapping Martian Atmospheric Pressure with Ground-Based Near Infrared Spectroscopy

Abstract We present images of Mars obtained in the 2.0 μm CO2 band with the United Kingdom Infrared Telescope (UKIRT). The images reveal topographic features of the Martian surface that are usually invisible in direct albedo images at visible or IR wavelengths, but agree remarkably well with the topography of the planet as mapped by the MOLA instrument on Mars Global Surveyor. The CO2 band depth is a measure of the absorbing column of CO2 and hence determined primarily by the surface atmospheric pressure. The surface pressure variations are detected with a sensitivity of 4–5 Pa. We compare our data with radiative transfer models and find that the measured CO2 variation with pressure is consistent with the models. We discuss the possibility that similar observations might be used to observe atmospheric pressure changes due to Martian weather systems.
The Role of Vascular Resection in Pancreatic Cancer Treatment

Currently, porto‐mesenteric vein resection is a standard procedure at high‐volume pan‐ creatic centers. Experience in vascular surgery is indispensable for a modern pancreatic surgeon. Nowadays, only arterial resections still are a controversial issue. Nevertheless, attempts at resection involving reconstruction of the main arteries such as the coeliac axis, hepatic artery, and superior mesenteric artery (SMA) have been reported, although in small case series. An overview of the historical and contemporary methods for surgical management of superior mesenteric/portal vein involvement as well as arterial involve‐ ment by pancreatic cancer is presented. We compare the data from the literature with our data based on the examination and long‐term follow‐up of more than 300 radical pan‐ creatic resections. Seventy‐two of the presented patients underwent pancreatic resection with simultaneous vascular resection—SMPV in 65 cases (44 with resection of the portal vein, 15 with resection of the superior mesenteric vein, 6 with resection of the porto‐ mesenterial confluence), arterial in 2 and partial resections of IVC in 5 cases. Combined vascular resections were done in three cases. Both groups PVR and PR showed similarly close results in complication rates, mortality, and morbidity. Three and 5 years survival rates were 42 and 38% in PD group and 28 and 19% in the PVR group. The vascular resec ‐ tion must be performed only upon carefully selected patients with data for presence of resectable tumors or tumors with borderline resectability from the preoperative imaging studies. The prompt management of pancreatic cancer with vascular involvement should involve multidisciplinary consultation in high‐volume centers.
Zhenbao pill protects against acute spinal cord injury via miR-146a-5p regulating the expression of GPR17

The aim of the present study was to observe the effect of zhenbao pill on the motor function of acute spinal cord injury (ASCI) rats and the molecular mechanisms involving miR-146a-5p and G-protein-coupled receptor 17 (GPR17). ASCI rat model was established by modified Allen method, and then the rats were divided into three groups. SH-SY5Y cells were cultured overnight in hypoxia condition and transfected with miR-146a-5p mimic or miR-146a-5p inhibitor. The hind limb motor function of the rats was evaluated by Basso, Beattie, Bresnahan (BBB) scoring system. Quantitative real-time PCR (qRT-PCR) and Western blot were used to detect the expression of miR-146a-5p, GPR17, inducible nitric oxide synthase (iNOS), interleukin 1β (IL-1β), and tumor necrosis factor α (TNF-α). Neuronal apoptosis was measured using flow cytometry assay. Luciferase reporter assay was performed to determine the regulation of miR-146a-5p on GPR17. Zhenbao pill could enhance hind limb motor function and attenuate the inflammatory response caused by ASCI. Moreover, zhenbao pill increased the level of miR-146a-5p and decreased GPR17 expression in vivo and in vitro. Bioinformatics software predicted that GPR17 3′-UTR had a binding site with miR-146a-5p. Luciferase reporter assay showed that miR-146a-5p had a negative regulatory effect on GPR17 expression. Knockdown of miR-146a-5p could reverse the effect of zhenbao pill on the up-regulation of GPR17 induced by hypoxia, reversed the inhibitory effect of zhenbao pill on the cell apoptosis induced by hypoxia and the recovery of zhenbao pill on hind limb motor function in ASCI rats. Zhenbao pill could inhibit neuronal apoptosis by regulating miR-146a-5p/GPR17 expression, and then promoting the recovery of spinal cord function.
Diabetes Prevention through Village Health Support Guides in Cambodia: A Qualitative Investigation of Opportunities and Challenges

Objectives: Lifestyle modification can prevent type II diabetes. Rates of diabetes are high in Cambodia. The Cambodian genocide and its aftermath resulted in destruction of the healthcare system and a critical shortage in the Cambodian healthcare workforce. Cambodia has a well-established system of community health workers, or village health support guides (Guides). This study explored opportunities for and challenges to training Guides to deliver diabetes prevention interventions. Design: In depth interviews were conducted with 12 Guides in Khmer. Guides also completed a 22-item validated Khmer language quiz regarding their knowledge of diabetes. Results: Participants were 75% female, on average 52 years old, with 8 years of education and 9 years Guides experience. Guides were aware that diabetes is a problem for their communities and were eager to address it. However, they had very low diabetes knowledge (quiz mean=57% correct). Three themes emerged: dedication to being a Guide, current responsibilities and need for additional and high quality training, and striving to do a good job in the face of barriers and insufficient resources. Participants easily identified factors that would support their own training in diabetes, and factors that would promote their teaching diabetes prevention in their villages. Conclusions: Diabetes prevention is overdue in Cambodia. Guides are poised to be trained to deliver these programs. Such training should be responsive to their perceived needs. Political will must be cultivated to support appropriate resources.
Protein Function Prediction Using Deep Restricted Boltzmann Machines

Accurately annotating biological functions of proteins is one of the key tasks in the postgenome era. Many machine learning based methods have been applied to predict functional annotations of proteins, but this task is rarely solved by deep learning techniques. Deep learning techniques recently have been successfully applied to a wide range of problems, such as video, images, and nature language processing. Inspired by these successful applications, we investigate deep restricted Boltzmann machines (DRBM), a representative deep learning technique, to predict the missing functional annotations of partially annotated proteins. Experimental results on Homo sapiens, Saccharomyces cerevisiae, Mus musculus, and Drosophila show that DRBM achieves better performance than other related methods across different evaluation metrics, and it also runs faster than these comparing methods.
Ecological risk assessment of pelagic sharks caught in Atlantic pelagic longline fisheries

An ecological risk assessment (ERA; also known as productivity and susceptibility analysis, PSA) was conducted on eleven species of pelagic elasmobranchs (10 sharks and 1 ray) to assess their vulnerability to pelagic longline fisheries in the Atlantic Ocean. This was a level-3 quantitative assessment consisting of a risk analysis to evaluate the biological productivity of these species and a susceptibility analysis to assess their propensity to capture and mortality in pelagic longline fisheries. The risk analysis estimated productivity (intrinsic rate of increase, r) using a stochastic Leslie matrix approach that incorporated uncertainty in age at maturity, lifespan, age-specific natural mortality and fecundity. Susceptibility to the fishery was calculated as the product of four components, which were also calculated quantitatively: availability of the species to the fleet, encounterability of the gear given the species vertical distribution, gear selectivity and post-capture mortality. Information from observer programs by several ICCAT nations was used to derive fleet-specific susceptibility values. Results indicated that most species of pelagic sharks have low productivities and varying levels of susceptibility to pelagic longline gear. A number of species were grouped near the high-risk area of the productivity-susceptibility plot, particularly the silky (Carcharhinus falciformis), shortfin mako (Isurus oxyrinchus), and bigeye thresher (Alopias superciliosus) sharks. Other species, such as the oceanic whitetip (Carcharhinus longimanus) and longfin mako (Isurus paucus) sharks, are also highly vulnerable. The blue shark (Prionace glauca) has intermediate vulnerability, whereas the smooth hammerhead (Sphyrna zygaena), scalloped hammerhead (Sphyrna lewini), and porbeagle (Lamna nasus) sharks are less vulnerable, and the pelagic stingray (Pteroplatytrygon violacea) and common thresher (Alopias vulpinus) sharks have the lowest vulnerabilities. As a group, pelagic sharks are particularly vulnerable to pelagic longline fisheries mostly as a result of their limited productivity.
Probabilistic Word Selection via Topic Modeling

We propose selective supervised Latent Dirichlet Allocation (ssLDA) to boost the prediction performance of the widely studied supervised probabilistic topic models. We introduce a Bernoulli distribution for each word in one given document to selectthis word as a strongly or weakly discriminative one with respect to its assigned topic. The Bernoulli distribution is parameterized by the discrimination power of the word for its assigned topic. As a result, the document is represented as a “bag-of-selective-words” instead of the probabilistic “bag-of-topics” in the topic modeling domain or the flat “bag-of-words” in the traditional natural language processing domain to form a new perspective. Inheriting the general framework of supervised LDA (sLDA), ssLDA can also predict many types of response specified by a Gaussian Linear Model (GLM). Focusing on the utilization of this word selection mechanism for singe-label document classification in this paper, we conduct the variational inference for approximating the intractable posterior and derive a maximum-likelihood estimation of parameters in ssLDA. The experiments reported on textual documents show that ssLDA not only performs competitively over “state-of-the-art” classification approaches based on both the flat “bag-of-words” and probabilistic “bag-of-topics” representation in terms of classification performance, but also has the ability to discover the discrimination power of the words specified in the topics (compatible with our rational knowledge).
Contrasat - A Contrarian SAT Solver

The SAT solver Contrasat is a small variation of the well-established Minisat solver. It was entered in the Minisat hack track of the 2011 SAT competition, and was judged to be first place in one category. This paper describes the code change and its motivation. The characterization as “contrarian” is explained. Experimental results are summarized.
Pain-Related Anxiety as a Predictor of Early Lapse and Relapse to Cigarette Smoking

Although emerging research suggests that pain-related anxiety may play a role in the maintenance of tobacco dependence, no previous work has examined pain-related anxiety as a predictor of smoking cessation outcomes. The current study aimed to test the hypothesis that pain-related anxiety would predict early lapse and relapse to cigarette smoking. These data were collected in the context of a primary study examining the role of emotional vulnerabilities in smoking cessation. The current analyses were conducted among 55 daily cigarette smokers who attempted to quit without psychosocial or pharmacological cessation aids. Pain-related anxiety was assessed at baseline using the Pain Anxiety Symptom Scale-20 (PASS-20). Early lapse and relapse were assessed using timeline follow-back procedures. Cox regression analyses indicated that pain-related anxiety was a significant predictor of both early smoking lapse and relapse such that for every 1-point increase on the PASS-20, the risk of early lapse increased by 3.7% and the risk of early relapse increased by 3.6%. These effects were evident above and beyond the variance accounted for by tobacco dependence, past 4-week pain severity, anxiety sensitivity, and the presence of current Axis I psychopathology. Kaplan-Meier survival analyses further revealed that among early lapsers, greater pain-related anxiety predicted a more rapid trajectory to lapse. Pain-related anxiety was also a significant predictor of early lapse when the sample was limited to smokers with past 4-week pain. These findings lend empirical support to the notion that pain-related anxiety may contribute to the maintenance of tobacco dependence among smokers who experience varying levels of pain intensity.
RESEARCH Integrative Cardiovascular Physiology and Pathophysiology VEGF nanoparticles repair the heart after myocardial infarction

repair the heart after myocardial infarction. Am J Physiol Heart Circ Physiol 314: H278–H284, 2018. Vascular endothelial growth factor (VEGF) is a well-characterized proangiogenic cytokine that has been shown to promote neovascularization in hearts of patients with ischemic heart disease but can also lead to adverse effects depending on the dose and mode of delivery. We investigated whether prolonged exposure to a low dose of VEGF could be achieved by encapsulating VEGF in polylactic coglycolic acid nanoparticles and whether treatment with VEGF-containing nanoparticles improved cardiac function and protected against left ventricular remodeling in the hearts of mice with experimentally induced myocardial infarction. Polylactic coglycolic acid nanoparticles with a mean diameter of ~113 nm were generated via double emulsion and loaded with VEGF; the encapsulation efﬁciency was 53.5 (cid:2) 1.7% (107.1 (cid:2) 3.3 ng VEGF/mg nano-particles). In culture, VEGF nanoparticles released VEGF continu- ously for at least 31 days, and in a murine myocardial infarction model, VEGF nanoparticle administration was associated with signif- icantly greater vascular density in the peri-infarct region, reductions in infarct size, and improvements in left ventricular contractile function 4 wk after treatment. Thus, our study provides proof of principle that nanoparticle-mediated delivery increases the angiogenic and thera- peutic potency of VEGF for the treatment of ischemic heart disease. NEW & NOTEWORTHY Vascular endothelial growth factor (VEGF) is a well-characterized proangiogenic cytokine but has a short half-life and a rapid clearance rate. When encapsulated in nanoparticles, VEGF was released for 31 days and improved left ventricular function in infarcted mouse hearts. These observations indicate that our new platform increases the therapeutic potency of VEGF.
Querying Probabilistic Ontologies with SPARQL

In recent years a lot of efforts was put into the field of Semantic Web research to specify knowledge as precisely as possible. However, optimizing for precision alone is not sufficient. The handling of uncertain or incomplete information is getting more and more important and it promises to significantly improve the quality of query answering in Semantic Web applications. My plan is to develop a framework that extends the rich semantics offered by ontologies with probabilistic information, stores this in a probabilistic database and provides query answering with the help of query rewriting. In this proposal I describe how these three aspects can be combined. Especially, I am focusing on how uncertainty is incorporated into the ABox and how it is handled by the database and the rewriter during query answering.
Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats

There have been a few descriptive studies in aged rodents about transcriptome changes in the hippocampus, most of them in males. Here, we assessed the age changes in spatial memory performance and hippocampal morphology in female rats and compared those changes with changes in the hippocampal transcriptome. Old rats displayed significant deficits in spatial memory. In both age groups, hole exploration frequency showed a clear peak at hole 0 (escape hole), but the amplitude of the peak was significantly higher in the young than in the old animals. In the hippocampus, there was a dramatic reduction in neurogenesis, whereas reactive microglial infiltrates revealed an inflammatory hippocampal state in the senile rats. Hippocampal RNA‐sequencing showed that 210 genes are differentially expressed in the senile rats, most of them being downregulated. Our RNA‐Seq data showed that various genes involved in the immune response, including TYROBP, CD11b, C3, CD18, CD4, and CD74, are overexpressed in the hippocampus of aged female rats. Enrichment analysis showed that the pathways overrepresented in the senile rats matched those of an exacerbated inflammatory environment, reinforcing our morphologic findings. After correlating our results with public data of human and mouse hippocampal gene expression, we found an 11‐gene signature of overexpressed genes related to inflammatory processes that was conserved across species. We conclude that age‐related hippocampal deficits in female rats share commonalities between human and rodents. Interestingly, the 11‐gene signature that we identified may represent a cluster of immune and regulatory genes that are deregulated in the hippocampus and possibly other brain regions during aging as well as in some neurodegenerative diseases and low‐grade brain tumors. Our study further supports neuroinflammation as a promising target to treat cognitive dysfunction in old individuals and some brain tumors. © 2017 Wiley Periodicals, Inc.
Computational Approaches to Pronoun Resolution

In this paper I review and analyze four proposals for pronoun refer- ence resolution: Hobbs' naive approach (5), an approach based on centering by Brennan, Friedman and Pollard (1), Lappin and Leass' salience method (8), and Kennedy and Boguraev's flat-syntax version of the salience method (7). I discuss to what extent the proposals can really claim to be computational and how this conformance to an algorithm and other related notions should guide our interpretation of published results about their quantitative performance. Their general coverage of the phenomenon and possibilities of being im- proved are treated in order to suggest about long term life of the approaches.
High Altitude Affects Nocturnal Non-linear Heart Rate Variability: PATCH-HA Study

Background: High altitude (HA) exposure can lead to changes in resting heart rate variability (HRV), which may be linked to acute mountain sickness (AMS) development. Compared with traditional HRV measures, non-linear HRV appears to offer incremental and prognostic data, yet its utility and relationship to AMS have been barely examined at HA. This study sought to examine this relationship at terrestrial HA. Methods: Sixteen healthy British military servicemen were studied at baseline (800 m, first night) and over eight consecutive nights, at a sleeping altitude of up to 3600 m. A disposable cardiac patch monitor was used, to record the nocturnal cardiac inter-beat interval data, over 1 h (0200–0300 h), for offline HRV assessment. Non-linear HRV measures included Sample entropy (SampEn), the short (α1, 4–12 beats) and long-term (α2, 13–64 beats) detrend fluctuation analysis slope and the correlation dimension (D2). The maximal rating of perceived exertion (RPE), during daily exercise, was assessed using the Borg 6–20 RPE scale. Results: All subjects completed the HA exposure. The average age of included subjects was 31.4 ± 8.1 years. HA led to a significant fall in SpO2 and increase in heart rate, LLS and RPE. There were no significant changes in the ECG-derived respiratory rate or in any of the time domain measures of HRV during sleep. The only notable changes in frequency domain measures of HRV were an increase in LF and fall in HFnu power at the highest altitude. Conversely, SampEn, SD1/SD2 and D2 all fell, whereas α1 and α2 increased (p < 0.05). RPE inversely correlated with SD1/SD2 (r = -0.31; p = 0.002), SampEn (r = -0.22; p = 0.03), HFnu (r = -0.27; p = 0.007) and positively correlated with LF (r = 0.24; p = 0.02), LF/HF (r = 0.24; p = 0.02), α1 (r = 0.32; p = 0.002) and α2 (r = 0.21; p = 0.04). AMS occurred in 7/16 subjects (43.8%) and was very mild in 85.7% of cases. HRV failed to predict AMS. Conclusion: Non-linear HRV is more sensitive to the effects of HA than time and frequency domain indices. HA leads to a compensatory decrease in nocturnal HRV and complexity, which is influenced by the RPE measured at the end of the previous day. HRV failed to predict AMS development.
It is not just about occupation, but also about where you work

OBJECTIVES Dentistry is characterized by a meaningful but also stressful psychosocial working environment. Job satisfaction varies among staff working under different organizational forms. The aim of this study was to identify (i) to what extent crucial psychosocial work environment characteristics differ among occupations in general public dental clinics in Sweden, and (ii) how much of the variation within each occupation is attributable to the organizational level. METHODS All staff (N=1782) employed in four public dental organizations received an email with personal log-in to an electronic questionnaire based on the Copenhagen Psychosocial Questionnaire. After two reminders, a response rate of 75% was obtained. Responses from 880 nonmanagerial dentists, dental hygienists and dental nurses working in general practices were included in our analyses. RESULTS First, we compared the three dental occupations. We found that job demands, task resources (eg influence, possibilities for development and role clarity), strain symptoms and attitudes to work differed among occupations, dentists having the least favourable situation. Next, we compared the four organizations for each occupational group, separately. For dentists, a significant and relevant amount of variance (P<.05 and ICC >.05) was explained by the organizational level for 15 of 26 subscales, least pronounced for task resources. By contrast, for dental nurses and hygienists, the corresponding number was 2 subscales of 26. The psychosocial working environment of people working at the organization with the highest levels of strain indicators and the least positive work-related attitudes differed systematically from the organization with the most favourable profile, in particular regarding job demands and leadership aspects. CONCLUSION In conclusion, the psychosocial working environment depended to a large degree on occupation and, for dentists in particular, also on their organizational affiliation. The findings suggest a potential for designing interventions at organizational level for improvements of the psychosocial working environment for dentists.