Miracle-dz/UniFAR-FTUs huggingface dataset:
A Model-Based Approach to Optimizing Ultradian Forced Desynchrony Protocols for Human Circadian Research

The human circadian system regulates internal 24-h rhythmicity and plays an important role in many aspects of human health and behavior. To investigate properties of the human circadian pacemaker such as intrinsic period and light sensitivity, experimental researchers have developed forced desynchrony (FD) protocols in which manipulations of the light-dark (LD) cycle are used to desynchronize the intrinsic circadian rhythm from the rest-activity cycle. FD protocols have typically been based on exposure to long LD cycles, but recently, ultradian FD protocols with short LD cycles have been proposed as a new methodology for assessing intrinsic circadian period. However, the effects of ultradian FD protocol design, including light intensity or study duration, on estimates of intrinsic circadian period have not, to our knowledge, been systematically studied. To address this gap, we applied a light-sensitive, dynamic mathematical model of the human circadian pacemaker to simulate ultradian FD protocols and analyze the effects of protocol design on estimates of intrinsic circadian period. We found that optimal estimates were obtained using protocols with low light intensities, at least 10 d of exposure to ultradian cycling, and a 7-h LD cycle duration that facilitated uniform light exposure across all circadian phases. Our results establish a theoretical framework for ultradian FD protocols that can be used to provide insights into data obtained under existing protocols and to optimize protocols for future experiments.
A bioinspired multi-modal flying and walking robot

With the aim to extend the versatility and adaptability of robots in complex environments, a novel multi-modal flying and walking robot is presented. The robot consists of a flying wing with adaptive morphology that can perform both long distance flight and walking in cluttered environments for local exploration. The robotʼs design is inspired by the common vampire bat Desmodus rotundus, which can perform aerial and terrestrial locomotion with limited trade-offs. Wings’ adaptive morphology allows the robot to modify the shape of its body in order to increase its efficiency during terrestrial locomotion. Furthermore, aerial and terrestrial capabilities are powered by a single locomotor apparatus, therefore it reduces the total complexity and weight of this multi-modal robot.
Negative Entropy, Zero temperature and stationary Markov Chains on the interval

We analyze some properties of maximizing stationary Markov probabilities on the Bernoulli space $[0,1]^\mathbb{N}$, More precisely, we consider ergodic optimization for a continuous potential $A$, where $A: [0,1]^\mathbb{N}\to \mathbb{R}$ which depends only on the two first coordinates. We are interested in finding stationary Markov probabilities $\mu_\infty$ on $ [0,1]^\mathbb{N}$ that maximize the value $ \int A d \mu,$ among all stationary Markov probabilities $\mu$ on $[0,1]^\mathbb{N}$. This problem correspond in Statistical Mechanics to the zero temperature case for the interaction described by the potential $A$. The main purpose of this paper is to show, under the hypothesis of uniqueness of the maximizing probability, a Large Deviation Principle for a family of absolutely continuous Markov probabilities $\mu_\beta$ which weakly converges to $\mu_\infty$. The probabilities $\mu_\beta$ are obtained via an information we get from a Perron operator and they satisfy a variational principle similar to the pressure. Under the hypothesis of $A$ being $C^2$ and the twist condition, that is, $\frac{\partial^2 A}{\partial_x \partial_y} (x,y) \neq 0$, for all $(x,y) \in [0,1]^2$, we show the graph property.
Conversational Agents and Natural Language Interaction: Techniques and Effective Practices

Conversational Agents and Natural Language Interaction: Techniques and Effective Practices is a reference guide for researchers entering the promising field of conversational agents. It provides an introduction to fundamental concepts in the field, collects experiences of researchers working on conversational agents, and reviews techniques for the design and application of conversational agents. The book discusses the successes of and challenges faced by researchers, designers, and programmers who want to use conversational agents for e-commerce, help desks, website navigation, personalized service, and training or education applications.
Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells1

IL-15 and IL-15Rα are required for generation of memory-phenotype CD8 T cells in unimmunized mice. However, the role of IL-15 in primary expansion and generation of Ag-specific memory CD8 T cells in vivo has not been investigated. We characterized the CD8 T cell response against vesicular stomatitis virus (VSV) in IL-15−/− and IL-15Rα−/− mice. Surprisingly, IL-15 was required for primary expansion of VSV-specific CD8 T cells. The generation of VSV-specific memory CD8 T cells was also impaired without IL-15 signaling, and this defect correlated with a decrease in memory CD8 T cell turnover. Despite minimal proliferation without IL-15, a subset of memory cells survived long-term. IL-15Rα expression was low on naive CD8 T cells, up-regulated on Ag-specific effector cells, and sustained on memory cells. Thus, IL-15 was important for the generation and the subsequent maintenance of antiviral memory CD8 T cells.
Substitution invariant Beatty sequences

if the infinite strings fƒÆ=f1f2f3 •c and W(fƒÆ)=w fi w f2 w f3 •c coincide. This situation was discussed by Brown [2] who displays non-trivial substitu tions W for certain quadratic irrationals ƒÆ. Subsequently Crisp, Moran, Pollington and Shiue [3] gave a complete description of all 6 admitting an invariant substitu tion. Their result agrees with the slightly different discussion of Ito and Yasutomi
2D vs 3D, implications on spatial memory

Since the introduction of graphical user interfaces (GUI) and two-dimensional (2D) displays, the concept of space has entered the information technology (IT) domain. Interactions with computers were re-encoded in terms of fidelity to the interactions with real environment and consequently in terms of fitness to cognitive and spatial abilities. A further step in this direction was the creation of three-dimensional (3D) displays which have amplified the fidelity of digital representations. However, there are no systematic results evaluating the extent to which 3D displays better support cognitive spatial abilities. The aim of this research is to empirically investigate spatial memory performance across different instances of 2D and 3D displays. Two experiments were performed. The displays used in the experimental situation represented hierarchical information structures. The results of the test show that the 3D display does improve performances in the designed spatial memory task.
On the Relationship between Perception of Usability and Subjective Mental Workload of Web Interfaces

Inspection methods and cheap self-reporting procedures have been significantly employed in the field of Human-Computer Interaction for assessing the usability of interfaces, systems and technologies. However, there is a tendency to overlook aspects related to the context and features of the users during the usability assessment process. This research introduces the concept of mental workload as an aid to enhance usability measurement. A user-study has been designed and executed in the context of human-web interaction. The aim was to investigate the relationship between the perception of usability of three popular web-sites, and the mental workload imposed by a set of typical tasks executed over them. Scores obtained with the System Usability Scale were compared to the mental workload scores obtained from the NASA Task Load Index and the Workload Profile assessment procedures. Findings suggest that perception of usability and mental workload are likely to be two non-overlapping constructs, and there is no clear evidence of their interaction. They measure two different aspects of human-system interaction and therefore they could be jointly employed to better describe user experience.
Comparison of arterial and capillary blood gas values in poisoning department assessment

The aim of this study was to compare simultaneously obtained arterial and capillary blood gas (CBG) values in comatose-poisoned patients presented with stable vital signs. Forty-five adult patients with a diagnosis of coma because of poisoning and stable vital signs were included in this prospective study. With respect to pH, the arterial blood gas (ABG) and CBG values correlated satisfactorily (r2 = .91) and had an acceptable limit of agreements (LOAs; —0.04 to 0.06). With respect to base excess (BE), the ABG and CBG values correlated well (r2 = .85), but their 95% LOAs seem too wide to allow substitution (—4.4 to 2.7). PCO2 (r2 = .61), HCO3 (r2 = .71) and PO2 (r2 = .53) correlated less reliably. A capillary PCO2 of 51.7 mm Hg had a sensitivity of 100% and a specificity of 95.12% for detecting hypercarbia (area under the curve, 0.99; 95% Confidence Interval, 0.90-0.99; p < .0001). In conclusion, CBG analysis for pH may be a reliable substitute for ABG analysis in the initial evaluation of patients presenting with coma and stable vital signs to the poisoning emergency department (PED). Subsequent ABG may be required in patients with capillary PCO2 > 51.7 mm Hg.
Study of antioxidant levels in patients with multiple myeloma

Multiple myeloma (MM), neoplastic disorder, is a B-cell malignancy characterised by the accumulation of clonal population of plasma cells. Reactive oxygen species and other free radicals mediate phenotypic and genotypic changes leading from mutation to neoplasia in all cancers including MM. In the present study, 50 clinically diagnosed patients with MM at stage II of international staging system and 50 healthy controls were included. β2 microglobulin levels were estimated by ELISA. The circulating levels of enzymatic antioxidants; superoxide dismutase (SOD), glutathione peroxidase (GPX) were spectrophotometrically estimated using RANDOX kits whereas catalase, malondialdehyde (MDA), vitamin C and E were estimated by standardised protocols using spectrophotometer/fluorometer. The serum β2 microglobulin levels were significantly higher (>3 µg/mL) in patients with MM than healthy controls. The estimated levels of SOD, GPX and catalase (enzymatic antioxidants) and vitamin C and E (non-enzymatic antioxidants) were significantly declined in patients whereas MDA levels were elevated as compared with controls. These results suggest that MM is closely associated with oxidative stress and reduced antioxidant capacity and further investigation might provide an insight to understand a putative causal link between oxidative stress and MM disease progression.
Colloidal Double Quantum Dots

Conspectus Pairs of coupled quantum dots with controlled coupling between the two potential wells serve as an extremely rich system, exhibiting a plethora of optical phenomena that do not exist in each of the isolated constituent dots. Over the past decade, coupled quantum systems have been under extensive study in the context of epitaxially grown quantum dots (QDs), but only a handful of examples have been reported with colloidal QDs. This is mostly due to the difficulties in controllably growing nanoparticles that encapsulate within them two dots separated by an energetic barrier via colloidal synthesis methods. Recent advances in colloidal synthesis methods have enabled the first clear demonstrations of colloidal double quantum dots and allowed for the first exploratory studies into their optical properties. Nevertheless, colloidal double QDs can offer an extended level of structural manipulation that allows not only for a broader range of materials to be used as compared with epitaxially grown counterparts but also for more complex control over the coupling mechanisms and coupling strength between two spatially separated quantum dots. The photophysics of these nanostructures is governed by the balance between two coupling mechanisms. The first is via dipole–dipole interactions between the two constituent components, leading to energy transfer between them. The second is associated with overlap of excited carrier wave functions, leading to charge transfer and multicarrier interactions between the two components. The magnitude of the coupling between the two subcomponents is determined by the detailed potential landscape within the nanocrystals (NCs). One of the hallmarks of double QDs is the observation of dual-color emission from a single nanoparticle, which allows for detailed spectroscopy of their properties down to the single particle level. Furthermore, rational design of the two coupled subsystems enables one to tune the emission statistics from single photon emission to classical emission. Dual emission also provides these NCs with more advanced functionalities than the isolated components. The ability to better tailor the emission spectrum can be advantageous for color designed LEDs in lighting and display applications. The different response of the two emission colors to external stimuli enables ratiometric sensing. Control over hot carrier dynamics within such structures allows for photoluminescence upconversion. This Account first provides a description of the main hurdles toward the synthesis of colloidal double QDs and an overview of the growing library of synthetic pathways toward constructing them. The main discoveries regarding their photophysical properties are then described in detail, followed by an overview of potential applications taking advantage of the double-dot structure. Finally, a perspective and outlook for their future development is provided.
pyd Genes of Rhizobium sp. Strain TAL1145 Are Required for Degradation of 3-Hydroxy-4-Pyridone, an Aromatic Intermediate in Mimosine Metabolism

ABSTRACT Rhizobium sp. strain TAL1145 degrades the Leucaena toxin mimosine and its degradation product 3-hydroxy-4-pyridone (HP). The aim of this investigation is to characterize the Rhizobium genes for HP degradation and transport. These genes were localized by subcloning and mutagenesis on a previously isolated cosmid, pUHR263, containing mid genes of TAL1145 required for mimosine degradation. Two structural genes, pydA and pydB, encoding a metacleavage dioxygenase and a hydrolase, respectively, are required for degradation of HP, and three genes, pydC, pydD, and pydE, encoding proteins of an ABC transporter, are involved in the uptake of HP by TAL1145. These genes are induced by HP, although both pydA and pydB show low levels of expression without HP. pydA and pydB are cotranscribed, while pydC, pydD, and pydE are each transcribed from separate promoters. PydA and PydB show no homology with other dioxygenases and hydrolases in Sinorhizobium meliloti, Mesorhizobium loti, and Bradyrhizobium japonicum. Among various root nodule bacteria, the ability to degrade mimosine or HP is unique to some Leucaena-nodulating Rhizobium strains.
Large scale Semi-Global Matching on the CPU

Semi-Global Matching (SGM) is widely used for real-time stereo vision in the automotive context. Despite its popularity, only implementations using reconfigurable hardware (FPGA) or graphics hardware (GPU) achieve high enough frame rates for intelligent vehicles. Existing real-time implementations for general purpose PCs use image and disparity sub-sampling at the expense of matching quality. We study methods to improve the efficiency of SGM on general purpose PCs, through fine grained parallelization and usage of multiple cores. The different approaches are evaluated on the KITTI benchmark, which provides real imagery with LIDAR ground truth. The system is able to compute disparity maps of VGA image pairs with a disparity range of 128 values at more than 16 Hz. The approach is scalable to the number of available cores and portable to embedded processors.
Methods for Designing Privacy Aware Information Systems: A Review

A major challenge in the field of software engineering is to make users trust the software that they use in their everyday professional or recreational activities. Trusting software depends on various elements, one of which is the protection of user privacy. Protecting privacy is about complying with user’s desires when it comes to handling personal information. It can also be defined as the right to determine when, how and to what extend information about them is communicated to others. The aim of this paper is to bring forward the modern practices for ensuring privacy during the design of information systems. To this end, it provides an overview of recent requirements engineering approaches which focus on the elicitation and management of privacy requirements. Comparative analysis of these approaches based on a systematic framework reflects on current research trends as well as open issues that provide a foundation for further research.
Neurological and endocrine phenotypes of fragile X carrier women

Women who carry fragile X mental retardation 1 (FMR1)gene premutation expansions frequently report neurological or endocrine symptoms and prior studies have predominantly focused on questionnaire report of medical issues. Premutation carrier (PMC) women (n = 33) and non‐carrier controls (n = 13) were recruited and evaluated by a neurologist, neuropsychologist, and endocrinologist. Blood and skin biopsies were collected for molecular measures. Scales for movement disorders, neuropathy, cognitive function, psychiatric symptoms, sleep, and quality of life were completed. The average age of the women was 51 years (n = 46) and average CGG repeat size was 91 ± 24.9 in the FMR1 PMC women. Seventy percent of the PMC women had an abnormal neurological examination. PMC women had significantly higher scores on the Fragile X‐Associated Tremor Ataxia Syndrome (FXTAS) rating scale, more neuropathy, and difficulty with tandem gait compared to controls. Central sensitivity syndromes, a neuroticism profile on the NEO Personality Profile, and sleep disorders were also prevalent. Discrepancies between subject report and examination findings were also seen. This pilot study suggests that women with the FMR1 premutation may have a phenotype that overlaps with that seen in FXTAS. Additional research with larger sample sizes is warranted to better delineate the clinical features.
On Minimum Variance Unbiased Estimation of Clock Offset in a Two-Way Message Exchange Mechanism

For many applications, distributed networks require the local clocks of the constituent nodes to run close to an agreed upon notion of time. Most of the widely used clock synchronization algorithms in such systems employ the sender-receiver protocol based on a two-way timing message exchange paradigm. Maximum likelihood estimator (MLE) of the clock offset based on the timing message exchanges between two clocks was derived in D. R. Jeske, On maximum likelihood estimation of clock offset[IEEE Trans. Commun. , vol. 53, pp. 53-54, Jan. 2005], when the fixed delays are symmetric and the variable delays in each direction assume an exponential distribution with an unknown mean. Herein, the best linear unbiased estimate using order statistics (BLUE-OS) of the clock offset between two nodes is derived assuming both symmetric and asymmetric exponential network delays, respectively. The Rao-Blackwell-Lehmann-Scheffe¿ theorem is then exploited to obtain the minimum variance unbiased estimate (MVUE) for the clock offset which it is shown to coincide with the BLUE-OS. In addition, it is found that the MVUE of the clock offset in the presence of symmetric network delays also coincides with the MLE. Finally, in the presence of asymmetric network delays, although the MLE is biased, it is shown to achieve lesser mean-square error (MSE) than the MVUE in the region around the point where the bidirectional network link delays are symmetric and hence its merit as the most versatile estimator is fairly justified.
PROACTIVE STRESS MANAGEMENT: THE NATURE, EFFECT AND IMPLICATIONS OF THE SOUTH AFRICAN POLICE SERVICE’S “MANAGING STRESS EFFECTIVELY” PROGRAMME

The need for a stress-management programme can generally be attributed to the fact that police work is often extremely stressful and that police officials tend to suffer from a variety of stressinduced physiological, psychological and behavioural disorders. McCraty, Atkinson and Tompson (1999:1-3) argue that particular attention should be given to occupational stress in policing as its potentially negative consequences affect society in more direct and critical ways than for most other organisations. It was, therefore, crucial that a stress-management programme should be developed for the South African Police Service (SAPS).
Sex on demand: geosocial networking phone apps and risk of sexually transmitted infections among a cross-sectional sample of men who have sex with men in Los Angeles county

Background Geosocial networking applications (GSN apps) used for meeting sexual partners have become increasingly popular with men who have sex with men (MSM) since 2009. The current study aimed to determine if self-identified HIV-negative, MSM clinic attendees who used GSN apps have an increased incidence of sexually transmitted infections (STI) compared to self-identified HIV-negative, MSM attendees who met sexual partners via in-person venues, such as bars or clubs or through MSM-specific hook-up websites. Methods Data were collected between August 2011 and January 2013 on all self-identified HIV-negative, MSM clients visiting the L.A. Gay & Lesbian Center for STI screening. A total of 7184 individuals tested for STIs and self-reported behaviours on drug use and social networking methods to meet sexual partners. Multivariate logistic regression models were used to analyse the results. Results Individuals who used GSN apps for meeting sexual partners had greater odds of testing positive for gonorrhoea (OR: 1.25; 95% CI 1.06 to 1.48) and for chlamydia (OR: 1.37; 95% CI 1.13 to 1.65) compared to individuals who met partners through in-person methods only. There were no significant differences in syphilis and HIV incidence between those who met partners via in-person venues only, on the internet or through GSN apps. Conclusions The present study concludes that sexual health clinic MSM attendees who are meeting on GSN apps are at greater risk for gonorrhoea and chlamydia than MSM attendees who meet in-person or on the internet. Future interventions should explore the use of these novel technologies for testing promotion, prevention and education.
Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3)

Mo1 (complement receptor type 3, CR3; CD11b/CD18) is an adhesion- promoting human leukocyte surface membrane heterodimer (alpha subunit 155 kD [CD11b] noncovalently linked to a beta subunit of 95 kD [CD18]). The complete amino acid sequence deduced from cDNA of the human alpha subunit is reported. The protein consists of 1,136 amino acids with a long amino-terminal extracytoplasmic domain, a 26-amino acid hydrophobic transmembrane segment, and a 19-carboxyl-terminal cytoplasmic domain. The extracytoplasmic region has three putative Ca2+- binding domains with good homology and one with weak homology to the "lock washer" Ca2+-binding consensus sequence. These metal-binding domains explain the divalent cation-dependent functions mediated by Mo1. The alpha subunit is highly homologous to the alpha subunit of leukocyte p150,95 and to a lesser extent, to the alpha subunit of other "integrin" receptors such as fibronectin, vitronectin, and platelet IIb/IIIa receptors in humans and position-specific antigen-2 (PS2) in Drosophila. Mo1 alpha, like p150, contains a unique 187-amino acid stretch NH2-terminal to the metal-binding domains. This region could be involved in some of the specific functions mediated by these leukocyte glycoproteins.