Miracle-dz/UniFAR-FTUs huggingface dataset:
Simplified treatment of the atrophic posterior maxilla via immediate/early function and tilted implants: A prospective 1-year clinical study.

BACKGROUND Posterior maxillae are often difficult to treat owing to the sinus antrum. Placing implants in remaining bone regions in the atrophic maxilla, without performing sinus grafting, is a challenge. Immediate function adds to this challenge. PURPOSE The purpose of this study was to suggest and evaluate a simplified treatment concept for the rehabilitation of the atrophic maxilla using tilted implants subjected to immediate/early function. MATERIALS AND METHODS Eighteen patients were included in the study. Sixty implants were placed to support 19 fixed partial or full-arch prostheses. Immediate/early function was applied. The patients were followed for a minimum of 1 year after prosthesis connection. Stability measurements and radiographic evaluation of the change of the marginal bone level were performed. RESULTS One axial and one tilted implant failed in one patient, giving a cumulative survival rate of 96.7%. No failure of provisional prostheses occurred. The mean marginal bone resorption recorded after 1 year was low (0.82 mm for axial implants and 0.34 mm for tilted implants). CONCLUSION The results of the present study suggest that tilted implants placed in immediate function may be a viable treatment approach for the rehabilitation of the atrophied maxilla. Simplified treatment procedures, reduced surgical invasion, shorter treatment time, and reduced costs constitute some of the benefits for the patient and the clinician.
Spatial genome organization during T-cell differentiation

The spatial organization of genomes within the mammalian cell nucleus is non-random. The functional relevance of spatial genome organization might be in influencing gene expression programs as cells undergo changes during development and differentiation. To gain insight into the plasticity of genomes in space and time and to correlate the activity of specific genes with their nuclear position, we systematically analyzed the spatial genome organization in differentiating mouse T-cells. We find significant global reorganization of centromeres, chromosomes and gene loci during the differentiation process. Centromeres were repositioned from a preferentially internal distribution in undifferentiated cells to a preferentially peripheral position in differentiated CD4+ and CD8+ cells. Chromosome 6, containing the differentially expressed T-cell markers CD4 and CD8, underwent differential changes in position depending on whether cells differentiated into CD4+ or CD8+ thymocytes. Similarly, the two marker loci CD4 and CD8 showed distinct behavior in their position relative to the chromosome 6 centromere at various stages of differentiation. Our results demonstrate that significant spatial genome reorganization occurs during differentiation and indicate that the relationship between dynamic genome topology and single gene regulation is highly complex.
The Effect of Ownership Structure on Market Valuation of Firms in India: Evidence from BSE-100 Index Companies

This study aims to test whether ownership and control concentration influences corporate market value of firms in BSE 100 Index companies in India from 2000-2014 covering all major sectors. The conceptual model is developed through a review of literature and is then implemented in the context of BSE (Bombay Stock Exchange) in India. A total data of BSE 100 Index companies for 15 years were considered. The panel data regression model is applied in order to draw the causal relationship between the variables considered for the study. The variables used are found to have a very good fit as it shows that every aspect of ownership has its own impact on market valuation. The study thus establishes that the non-promoters holding (if taken as an individual variable) and non-promoters non institutional holding have a significant impact on market capitalization of the firm. Furthermore, it is found that the non-promoters institutional holding and non-promoters non institutional holding have a significant impact on PB value of the firm. The study uses market capitalisation and PB value to check market valuation of firms. Also, this study has taken broader aspect of ownership structure into account. All parameters used in this study have not been studied in previous studies in Indian context. This study tries to fill this gap.
Developmental-stage-specific regulation of the polyubiquitin receptors in Drosophila melanogaster

Recognition of polyubiquitylated substrates by the proteasome is a highly regulated process that requires polyubiquitin receptors. We show here that the concentrations of the proteasomal and extraproteasomal polyubiquitin receptors change in a developmentally regulated fashion. The stoichiometry of the proteasomal p54/Rpn10 polyubiquitin receptor subunit, relative to that of other regulatory particle (RP) subunits falls suddenly at the end of embryogenesis, remains low throughout the larval stages, starts to increase again in the late third instar larvae and remains high in the pupae, adults and embryos. A similar developmentally regulated fluctuation was observed in the concentrations of the Rad23 and Dsk2 extraproteasomal polyubiquitin receptors. Depletion of the polyubiquitin receptors at the end of embryogenesis is due to the emergence of a developmentally regulated selective proteolytic activity. To follow the fate of subunit p54/Rpn10 in vivo, transgenic Drosophila melanogaster lines encoding the N-terminal half (NTH), the C-terminal half (CTH) or the full-length p54/Rpn10 subunit were established in the inducible Gal4-UAS system. The daughterless-Gal4-driven whole-body expression of the full-length subunit or its NTH did not produce any detectable phenotypic changes, and the transgenic products were incorporated into the 26S proteasome. The transgene-encoded CTH was not incorporated into the 26S proteasome, caused third instar larval lethality and was found to be multi-ubiquitylated. This modification, however, did not appear to be a degradation signal because the half-life of the CTH was over 48 hours. Accumulation of the CTH disturbed the developmentally regulated changes in subunit composition of the RP and the emergence of the selective proteolytic activity responsible for the depletion of the polyubiquitin receptors. Build-up of subunit p54/Rpn10 in the RP had already started in 84-hour-old larvae and reached the full complement characteristic of the non-larval developmental stages at the middle of the third instar larval stage, just before these larvae perished. Similar shifts were observed in the concentrations of the Rad23 and Dsk2 polyubiquitin receptors. The postsynthetic modification of CTH might be essential for this developmental regulation, or it might regulate an essential extraproteasomal function(s) of subunit p54/Rpn10 that is disturbed by the expression of an excess of CTH.
PCOS Analysis of heart rate variability in polycystic ovary syndrome

Objective. To compare the modulation of heart rate in a group of volunteers with polycystic ovary syndrome (PCOS) to that of a group of healthy ovulatory women on the basis of R-R interval variability and analyze the relationships between heart rate variability (HRV) and other cardiovascular risk factors. Methods. In a cross-sectional study, HRV and anthropometric, biochemical and hormonal parameters were measured in 23 women with PCOS and 23 age-matched controls. Mean outcomes measures: HRV indexes in the time (SDNN and rMSSD) and frequency domain (low frequency–LF and high frequency–HF). Differences between groups and correlation analysis were performed. Results. Intergroup analysis showed significant differences (p5 0.05) between groups, with lower SDNN, rMSSD, LF and HF indexes in PCOS women when compared to the control group. There was significant negative correlation between BMI and SDNN, LF and HF, indicating a decrease in the autonomic modulation of heart rate with increasing weight. A negative correlation was also found between the high-sensitivity C-reactive protein level and the rMSSD index. Conclusion. Our results show that PCOS is associated with alterations in the autonomic modulation of heart rate, possibly due to the influence of weight gain.
Transposon vectors containing non-antibiotic resistance selection markers for cloning and stable chromosomal insertion of foreign genes in gram-negative bacteria

A simple procedure for cloning and stable insertion of foreign genes into the chromosomes of gram-negative eubacteria was developed by combining in two sets of plasmids (i) the transposition features of Tn10 and Tn5; (ii) the resistances to the herbicide bialaphos, to mercuric salts and organomercurial compounds, and to arsenite, and (iii) the suicide delivery properties of the R6K-based plasmid pGP704. The resulting constructions contained unique NotI or SfiI sites internal to either the Tn10 or the Tn5 inverted repeats. These sites were readily used for cloning DNA fragments with the help of two additional specialized cloning plasmids, pUC18Not and pUC18Sfi. The newly derived constructions could be maintained only in donor host strains that produce the R6K-specified pi protein, which is an essential replication protein for R6K and plasmids derived therefrom. Donor plasmids containing hybrid transposons were transformed into a specialized lambda pir lysogenic Escherichia coli strain with a chromosomally integrated RP4 that provided broad-host-range conjugal transfer functions. Delivery of the donor plasmids into selected host bacteria was accomplished through mating with the target strain. Transposition of the hybrid transposon from the delivered suicide plasmid to a replicon in the target cell was mediated by the cognate transposase encoded on the plasmid at a site external to the transposon. Since the transposase function was not maintained in target cells, such cells were not immune to further transposition rounds. Multiple insertions in the same strain are therefore only limited by the availability of distinct selection markers. The utility of the system was demonstrated with a kanamycin resistance gene as a model foreign insert into Pseudomonas putida and a melanin gene from Streptomyces antibioticus into Klebsiella pneumoniae. Because of the modular nature of the functional parts of the cloning vectors, they can be easily modified and further selection markers can be incorporated. The cloning system described here will be particularly useful for the construction of hybrid bacteria that stably maintain inserted genes, perhaps in competitive situations (e.g., in open systems and natural environments), and that do not carry antibiotic resistance markers characteristic of most available cloning vectors (as is currently required of live bacterial vaccines).
Improving Quantitative Structure-Activity Relationships through Multiobjective Optimization

A multiobjective optimization algorithm was proposed for the automated integration of structure- and ligand-based molecular design. Driven by a genetic algorithm, the herein proposed approach enabled the detection of a number of trade-off QSAR models accounting simultaneously for two independent objectives. The first was biased toward best regressions among docking scores and biological affinities; the second minimized the atom displacements from a properly established crystal-based binding topology. Based on the concept of dominance, 3D QSAR equivalent models profiled the Pareto frontier and were, thus, designated as nondominated solutions of the search space. K-means clustering was, then, operated to select a representative subset of the available trade-off models. These were effectively subjected to GRID/GOLPE analyses for quantitatively featuring molecular determinants of ligand binding affinity. More specifically, it was demonstrated that a) diverse binding conformations occurred on the basis of the ligand ability to profitably contact different part of protein binding site; b) enzyme selectivity was better approached and interpreted by combining diverse equivalent models; and c) trade-off models were successful and even better than docking virtual screening, in retrieving at high sensitivity active hits from a large pool of chemically similar decoys. The approach was tested on a large series, very well-known to QSAR practitioners, of 3-amidinophenylalanine inhibitors of thrombin and trypsin, two serine proteases having rather different biological actions despite a high sequence similarity.
Visualization and replay memory database design for reinforcement learning in R

In this thesis, a basic intro to reinforcement learning, deep learning and database systems will be given. Reinforcement learning describes methods learning on data generated from acting in an environment. Unless conventional machine learning algorithms, these kind of artificial learners are meant to start with zero data. Additionally to the theoretical parts in this thesis, there will be several implementations in R not only for demonstration purposes, but also to help storing the generated data plus understanding the learning process in retrospective.
A comparative CAPEX Techno-economic Analysis of NFV Applicability on the ground segment of GEO / MEO / LEO Satellite Systems

This document contains information regarding the comparative CAPEX Techno-economic Analysis of NFV Applicability on the ground segment of GEO/MEO/LEO Satellite Systems. The views expressed in this document are not final, and are subject to change at any time. Although this document contains contributions from multiple parties, it is not a consensus document and does not necessarily reflect the views of any or all contributors. INFOLYSiS reserves all rights with respect to its technology and intellectual property that may be disclosed, covered, or reflected in this document. The only rights granted to you are to copy, print, and publicly display this document. All trademarks, service marks, trade names, trade dress, product names and logos appearing in this document are the property of their respective owners, including, in some instances, INFOLYSiS. All company, product and service names used in this document are for identification purposes only. Use of these names, logos, and brands does not imply endorsement. Neither INFOLYSiS nor any contributor to this document shall be responsible for any action taken by any person in reliance on anything contained herein.
LOCALLY LINEAR UNSUPERVISED FEATURE SELEC-

The paper, interested in unsupervised feature selection, aims to retain the features best accounting for the local patterns in the data. The proposed approach, called Locally Linear Unsupervised Feature Selection (LLUFS), relies on a dimensionality reduction method to characterize such patterns; each feature is thereafter assessed according to its compliance w.r. t. the local patterns, taking inspiration from Locally Linear Embedding (Roweis and Saul, 2000). The experimental validation of the approach on the scikit-feature benchmark suite demonstrates its effectiveness compared to the state of the art.
Illustrating Terrains using Direction of Slope and Lighting

Landscape illustrations and cartographic maps depict terrain surface in a qualitatively effective way. In this paper, we present a framework for line drawing techniques for automatically reproducing traditional illustrations of terrain by means of slope lines and tonal variations. Given a digital elevation model, surface measures are computed and slope lines of the terrain are hierarchically traced and stored. At run-time slope lines are rendered by stylized procedural and texture-based strokes. The stroke density of the final image is determined according to the light intensities. Using a texture based approach, the line drawing pipeline is encapsulated from the rendering of the terrain geometry. Our system operates on terrain data at interactive rates while maintaining frame-to-frame coherence.
Demonstration that bone mass is greater in black than in white children

Osteoporosis and hip fractures are less common and bone mass is greater in black than in white women. To determine if bone mass is greater in black than in white children, bone mineral density (BMD) of the midradius by single‐photon absorptiometry and BMD of the lumbar spine (L1‐L4), trochanter, and femoral neck by dual‐photon absorptiometry were measured in 20 black boys, 18 black girls, 33 white boys, and 35 white girls between the ages of 7 and 12 years. Mean age (10.4 ± 0.3 versus 10.2 ± 0.2 years) and body weight (39 ± 2 versus 38 ± 2 kg) in the blacks and whites, respectively, were not different in the two groups, and the ages and weights of the boys and girls were not different from each other. BMD were significantly greater in black than in white children at each site, in the black than in white boys at the trochanter and femoral neck, and in the black than in white girls at each site. In both races, BMD varied directly with age and body weight. Multivariate analysis showed that BMD were greater at the midradius, lumbar spine, trochanter, and femoral neck in the black than in the white children, that BMD of the lumbar spine was greater in the girls than in the boys, and that BMD of the trochanter and femoral neck were greater in the boys than in the girls. There were significant partial correlations between race and BMD and between BMD and body weight at each site, between sex and BMD at the lumbar spine, trochanter, and femoral neck, and between age and BMD at the midradius, trochanter, and femoral neck. Race, sex, age, and body weight together accounted for 49‐66% of the variation in bone mass. Thus, BMD of the midradius, spine, and hip are greater in black than in white children, body weight and age are important determinants of bone mass, and some sex differences in bone mass are present at this age.
Organic carbon sequestration and discharge from a deciduous forest catchment in Korea

Soil infiltration and surface discharge of precipitation are critical processes that affect the sequestration and discharge of dissolved organic carbon (DOC) and particulate organic carbon (POC) in forested catchments. Both DOC and POC are highly concentrated in the soil surface in most forest ecosystems and their discharge may not be negligible particularly under 15 the monsoon climate. In East Asia, however, there are little data available to evaluate the role of such processes in forest carbon budget. In this paper, we address two basic questions: (1) how does stream discharge respond to storm events in a forest catchment? and (2) how much DOC and POC are discharged from the catchment particularly during the summer monsoon period? To answer these questions, we collected hydrological data (e.g., precipitation, soil 20 moisture, runoff discharge, groundwater level) and conducted hydrochemical analyses (including DOC, POC, and six tracers) for a deciduous forest catchment in Gwangneung National Arboretum in west-central Korea. Based on the end-member mixing analysis of the six storm events during the summer monsoon in 2005, the surface discharge was estimated as 30 to 80% of the total runoff discharge. The stream discharge responded to precipitation 25 within 12 h during these storm events. The annual discharge of DOC and POC from the catchment was estimated as 0.04 and 0.05 t C ha yr, respectively. Approximately 70% of
Codigestion of solid wastes: A review of its uses and perspectives including modeling

The last two years have witnessed a dramatic increase in the number of papers published on the subject of codigestion, highlighting the relevance of this topic within anaerobic digestion research. Consequently, it seems appropriate to undertake a review of codigestion practices starting from the late 1970s, when the first papers related to this concept were published, and continuing to the present day, demonstrating the exponential growth in the interest shown in this approach in recent years. Following a general analysis of the situation, state-of-the-art codigestion is described, focusing on the two most important areas as regards publication: codigestion involving sewage sludge and the organic fraction of municipal solid waste (including a review of the secondary advantages for wastewater treatment plant related to biological nutrient removal), and codigestion in the agricultural sector, that is, including agricultural – farm wastes, and energy crops. Within these areas, a large number of oversized digesters appear which can be used to codigest other substrates, resulting in economic and environmental advantages. Although the situation may be changing, there is still a need for good examples on an industrial scale, particularly with regard to wastewater treatment plants, in order to extend this beneficial practice. In the last section, a detailed analysis of papers addressing the important aspect of modelisation is included. This analysis includes the first codigestion models to be developed as well as recent applications of the standardised anaerobic digestion model ADM1 to codigestion. (This review includes studies ranging from laboratory to industrial scale.)
Correlation of Daptomycin Resistance in a Clinical Staphylococcus aureus Strain with Increased Cell Wall Teichoic Acid Production and d-Alanylation

ABSTRACT Cell wall thickening is a common feature among daptomycin-resistant Staphylococcus aureus strains. However, the mechanism(s) leading to this phenotype is unknown. We examined a number of cell wall synthesis pathway parameters in an isogenic strain set of S. aureus bloodstream isolates obtained from a patient with recalcitrant endocarditis who failed daptomycin therapy, including the initial daptomycin-susceptible parental strain (strain 616) and two daptomycin-resistant strains (strains 701 and 703) isolated during daptomycin therapy. Transmission electron microscopy demonstrated significantly thicker cell walls in the daptomycin-resistant strains than in the daptomycin-susceptible strain, a finding which was compatible with significant differences in dry cell weight of strain 616 versus strains 701 to 703 (P < 0.05). Results of detailed analysis of cell wall muropeptide composition, the degree of peptide side chain cross-linkage, and the amount of the peptidoglycan precursor, UDP-MurNAc-pentapeptide, were similar in the daptomycin-susceptible and daptomycin-resistant isolates. In contrast, the daptomycin-resistant strains contained less O-acetylated peptidoglycan. Importantly, both daptomycin-resistant strains synthesized significantly more wall teichoic acid (WTA) than the parental strain (P < 0.001). Moreover, the proportion of d-alanylated WTA species was substantially higher in the daptomycin-resistant strains than in the daptomycin-susceptible parental strain (P < 0.05 in comparing strain 616 versus strain 701). The latter phenotypic findings correlated with (i) enhanced tagA and dltA gene expression, respectively, and (ii) an increase in surface positive charge observed in the daptomycin-resistant versus daptomycin-susceptible isolates. Collectively, these data suggest that increases in WTA synthesis and the degree of its d-alanylation may play a major role in the daptomycin-resistant phenotype in some S. aureus strains.
ECE 543 Final Project Principle of Maximum Conditional Entropy

This report focuses on gaining a better understanding of the principle of maximum entropy and its relation to supervised learning problems. In particular, we aim to understand the minimax expected loss over a family of distributions and of its relation to the maximum conditional entropy. We then study how this may be leveraged to design decision rules that are robust over the set of distributions. Fundamentally, we aim to obtain a better understanding of the role of entropy and information functionals as a more general definition, in learning problems.