Miracle-dz/UniFAR-FTUs huggingface dataset:
The subsyndromal phenomenology of borderline personality disorder: a 10-year follow-up study.

OBJECTIVE The purpose of this study was to characterize the course of 24 symptoms of borderline personality disorder in terms of time to remission. METHOD The borderline psychopathology of 362 patients with personality disorders, all recruited during inpatient stays, was assessed using two semistructured interviews of proven reliability. Of these, 290 patients met DSM-III-R criteria as well as Revised Diagnostic Interview for Borderlines criteria for borderline personality disorder, and 72 met DSM-III-R criteria for another axis II disorder. Over 85% of the patients were reinterviewed at five distinct 2-year follow-up waves by interviewers blind to all previously collected information. RESULTS Among borderline patients, 12 of the 24 symptoms studied showed patterns of sharp decline over time and were reported at 10-year follow-up by less than 15% of the patients who reported them at baseline. The other 12 symptoms showed patterns of substantial but less dramatic decline over the follow-up period. Symptoms reflecting core areas of impulsivity (e.g., self-mutilation and suicide efforts) and active attempts to manage interpersonal difficulties (e.g., problems with demandingness/entitlement and serious treatment regressions) seemed to resolve the most quickly. In contrast, affective symptoms reflecting areas of chronic dysphoria (e.g., anger and loneliness/emptiness) and interpersonal symptoms reflecting abandonment and dependency issues (e.g., intolerance of aloneness and counterdependency problems) seemed to be the most stable. CONCLUSIONS The results suggest that borderline personality disorder may consist of both symptoms that are manifestations of acute illness and symptoms that represent more enduring aspects of the disorder.
A novel unit selection method for concatenation speech system using similarity measure

This paper presents a new approach to unit selection for corpus-based TTS system, in which the units are selected according to their similarity with synthetic target generated by a parametric synthesizer. In the training stage, a group of classifiers are trained based on human perceptual judgments. The outputs of the classifiers are used to make a distinction rather than using traditional methods such as continuously-valued cost. In order to obtain a better classification result, different combinations of features are tried as input vectors, and the similarity rating is carried out dexterously. Subjective listening tests on a Mandarin female TTS system show that the proposed classifier based speech synthesis system outperforms the traditional unit-selection system.
A Cortically Blind Patient With Preserved Visual Imagery

Background/ObjectiveThe loss or preservation of visual imagery in patients with cortical blindness may be helpful in resolving the controversial roles assigned by some researchers to the early visual cortex during the process of visual imagery. Patient and MethodsHere we report a patient with complete permanent cortical blindness coupled with denial of the blindness (Anton syndrome) as a result of bilateral occipital infarction. ResultsInterestingly, the patient's ability to visualize objects, color, and spatial imagery was preserved, although cerebral computed tomography, magnetic resonance imaging, and positron emission tomography scans detected what was likely complete bilateral damage to the primary visual cortex. ConclusionsOur findings may support the hypothesis that the primary visual cortex, in which retinal spatial geometry is preserved, is not critical for visual imagery.
Biofilm imaging in porous media by laboratory X-Ray tomography: Combining a non-destructive contrast agent with propagation-based phase-contrast imaging tools

X-ray tomography is a powerful tool giving access to the morphology of biofilms, in 3D porous media, at the mesoscale. Due to the high water content of biofilms, the attenuation coefficient of biofilms and water are very close, hindering the distinction between biofilms and water without the use of contrast agents. Until now, the use of contrast agents such as barium sulfate, silver-coated micro-particles or 1-chloronaphtalene added to the liquid phase allowed imaging the biofilm 3D morphology. However, these contrast agents are not passive and potentially interact with the biofilm when injected into the sample. Here, we use a natural inorganic compound, namely iron sulfate, as a contrast agent progressively bounded in dilute or colloidal form into the EPS matrix during biofilm growth. By combining a very long source-to-detector distance on a X-ray laboratory source with a Lorentzian filter implemented prior to tomographic reconstruction, we substantially increase the contrast between the biofilm and the surrounding liquid, which allows revealing the 3D biofilm morphology. A comparison of this new method with the method proposed by Davit et al (Davit et al., 2011), which uses barium sulfate as a contrast agent to mark the liquid phase was performed. Quantitative evaluations between the methods revealed substantial differences for the volumetric fractions obtained from both methods. Namely, contrast agent—biofilm interactions (e.g. biofilm detachment) occurring during barium sulfate injection caused a reduction of the biofilm volumetric fraction of more than 50% and displacement of biofilm patches elsewhere in the column. Two key advantages of the newly proposed method are that passive addition of iron sulfate maintains the integrity of the biofilm prior to imaging, and that the biofilm itself is marked by the contrast agent, rather than the liquid phase as in other available methods. The iron sulfate method presented can be applied to understand biofilm development and bioclogging mechanisms in porous materials and the obtained biofilm morphology could be an ideal basis for 3D numerical calculations of hydrodynamic conditions to investigate biofilm-flow coupling.
A reduced field‐of‐view method to increase temporal resolution or reduce scan time in cine MRI

In some dynamic applications of MRI, only a part of the field‐of‐view (FOV) actually undergoes dynamic changes. A class of methods, called reduced‐FOV (rFOV) methods, convert the knowledge that some part of the FOV is static or not very dynamic into an increase in temporal resolution for the dynamic part, or into a reduction in the scan time. Although cardiac imaging is an important example of an imaging situation where changes are concentrated in a fraction of the FOV, the rFOV methods developed up to now are not compatible with one of the most common cardiac sequences, the so‐called retrospective cine method. The present work is a rFOV method designed to be compatible with cine imaging. An increase by a factor n in temporal resolution or a decrease by n in scan time is obtained in the case where only one nth of the FOV is dynamic (the rest being considered static). Results are presented for both Cartesian and spiral imaging. Magn Reson Med 43:549–558, 2000. © 2000 Wiley‐Liss, Inc.
Exaggerated MK‐801‐induced motor hyperactivity in rats with the neonatal lesion of the ventral hippocampus

Neonatal lesions of the ventral hippocampus in rats produce changes in spontaneous and pharmacologically induced dopamine‐dependent behaviors that emerge in early adulthood. Neural mechanisms underlying these changes may have implications for understanding the neurobiology of schizophrenia, putatively a neurodevelopmental disorder. In this study, we evaluated the effects of MK‐801 (dizocilpine), on automated measures of distance traveled and stereotypies in adult rats with neonatal (postnatal day 7) lesions, and tested the effects of haloperidol, clozapine and an AMPA antagonist LY293558 on the MK‐801‐induced behaviors. The lesioned rats showed significantly greater increases in motor activity after 0.05 and 0.1 mg/kg of MK‐801 than did controls. Both haloperidol (0.1 and 0.4 mg/kg) and clozapine (4 and 10 mg/kg) reduced hyperlocomotion elicited by 0.2 mg/kg MK‐801 in the ventral hippocampus (VH)‐lesioned and sham rats. Haloperidol was more potent than clozapine in decreasing MK‐801‐induced stereotypy, especially in the lesioned rats. Moreover, an AMPA antagonist normalized exaggerated MK‐801‐induced hyperolocomotion in the lesioned rats at doses that had no effect in controls. These results demonstrate that the lesioned rats are more sensitive to MK‐801 during adulthood than control rats, and that antidopaminergic drugs as well as AMPA antagonists antagonize the MK‐801‐induced behaviors. The neonatal lesion rat model may be useful to further our understanding of the interactions between dopamine and glutamate and their role in the pathophysiology of schizophrenia.
Lactate Dehydrogenase Is an AU-rich Element-binding Protein That Directly Interacts with AUF1*

Post-transcriptional pathways provide a major means of regulating eukaryotic gene expression. Reiterations of the AU-rich element (ARE) within the 3′-untranslated region of many cytokine and proto-oncogene mRNAs serve as signals for rapid degradation and translational repression. The identification of thiscis-acting stability determinant has fueled the search for ARE-binding proteins (AUBP) that function as trans-acting factors that transduce this function. Previous work identified heterogeneous nuclear ribonucleoprotein (hnRNP) A1 as a major AUBP capable of binding the ARE of granulocyte-macrophage colony stimulating factor (GM-CSF) RNA in the context of a full-length mRNA. We report here that functional studies failed to indicate a role for hnRNP A1 in ARE-dependent mRNA turnover. In an effort to identify other functionally relevant AUBP, the major GM-CSF ARE-specific binding protein in cells lacking hnRNP A1 was purified from CB3 mouse erythroleukemia cells. Microsequencing identified this protein as the glycolytic enzyme lactate dehydrogenase (LDH) M. RNA binding by LDH was shown to occur in the NAD+-binding region (Rossmann fold). Polysome gradient analysis demonstrates that LDH is found in the translationally active fraction. Polysomal localization of LDH was dependent on RNA binding. Moreover, polysomal LDH exists in a complex with AUF1 and hsp-70, which has been implicated previously in the regulation of mRNA turnover. The interaction between LDH and AUF1 is direct as it can be demonstrated in vitro with purified proteins. Collectively these data implicate a role for LDH in the post-transcriptional regulation of gene expression.
Learning a tool's homogeneous transformation by tactile-based interaction

We propose a tactile-based manipulation strategy to learn the homogeneous transformation of a grasped rigid tool, using tactile sensing delivered through a tactile matrix sensor covering the tool surface. Exploiting the self-learning tactile servoing controller, a robot safely use the tactile tool to implement different tactile-based exploration primitives (EPs). Considering EPs as input and observing the tactile contacts as output, the robot can robustly estimate the tool's homogeneous transformation. The learned transformation are combined with the known robot's kinematics model to form a new tool manipulation kinematics chain, thereby realizing a step towards a “plastic body schema” for flexible tool use by a robot. We numerically evaluate the method's feasibility and robustness assuming that measurements are only polluted by Gaussian white noise, then evaluate the proposed method with a real robot setup - a KUKA LWR and a SCHUNK SDH-2 hand grasping a rigid tactile tool. With the new manipulation chain, we demonstrate two tactile tool's servoing experiments: reactively sliding and rolling tool and tracking an unknown object edge.
Research Note: Modeling of the Water Quality of Büyüksu Stream, Bolu, Turkey

The QUAL2E model was applied to the Büyüksu Stream, Bolu, Turkey, to predict the effect of conventional and industrial pollutant sources on stream quality. The model parameters were conditioned using data from eight sampling stations on a 24‐km stretch of the stream during a steady‐state period between May 2003 and June 2004. The higher biochemical oxygen demand (>50 mg/L) and lower dissolved oxygen concentrations measured (<4.0 mg/L), with their expected values, indicated that the water quality of the Büyüksu Stream was threatened by industrial and domestic pollution. The oxygen‐sag curves obtained by the model calculations proved that discharges of the Bolu City wastewater and wood‐processing plant effluent were the two primary pollutant sources affecting the stream. Results suggested that the conditioned model can be used as a tool to show the effects of pollutant sources on the Büyüksu Stream and to assess improvements expected by reducing the contribution of pollutant sources.
Significance of Oral Administration of Sodium Perchlorate in Planning Liver-Directed Radioembolization

99mTc-macroaggregated albumin (99mTc-MAA) scanning precedes radioembolization of the liver to detect extrahepatic shunting to the lung or gastrointestinal tract. Despite strict preventive measures in the production of 99mTc-MAA and in scanning protocols, the images frequently show a gastric concentration of free 99mTc-pertechnetate, hindering accurate evaluation of the gastroduodenal region. Our aim was to evaluate whether oral administration of sodium perchlorate (NaClO4) before 99mTc-MAA scanning will improve its accuracy by blocking free 99mTc-pertechnetate gastric uptake. Methods: In 144 patients, 171 diagnostic hepatic angiograms combined with a 99mTc-MAA scan were performed; 86 angiograms were performed after oral administration of NaClO4, and 85 were performed without this premedication. Clinical follow-up, esophagogastroduodenoscopy, and angiography served as reference standards. Results: 99mTc-MAA studies showed tracer uptake in the gastric region of 25 patients who did not receive NaClO4. The uptake was interpreted as a free 99mTc-pertechnetate concentration in 21 studies and as a 99mTc-MAA accumulation in 4 studies. In 5 patients with a free 99mTc-pertechnetate concentration, aberrant vessels were detected in angiographic reexamination, and 3 patients developed gastrointestinal ulcer. In 7 studies, gastric findings viewed pretherapeutically as free 99mTc-pertechnetate were retrospectively classified as equivocal. Of the patients receiving NaClO4, 2 showed gastric accumulation of 99mTc-MAA but no equivocal or free 99mTc-pertechnetate. Oral administration of NaClO4 increased the negative predictive value and accuracy of the test concerning the detection of gastric perfusion from 68% and 69%, respectively, to 93% and 94%, respectively. Conclusion: Oral administration of NaClO4 before the test angiogram with 99mTc-MAA resulted in effective avoidance of free 99mTc-pertechnetate concentration and, consequently, of equivocal findings in the gastroduodenal region. This technique increased test accuracy and reporter confidence, saved time in reviewing the angiograms, and can improve treatment planning and reduce therapeutic side effects.
Soft Error-Aware Voltage Scaling Technique for Power Minimization in Application-Specific Multiprocessor System-on-Chip

There is growing interest in evaluating the impact of soft errors on multiprocessor system-on-chip (MPSoC) at application-level rather than architectural-level, particularly in multimedia applications to optimize system design. This has recently led to the concept of application-level correctness. In this paper, we consider the relationship between application-level correctness and system-level power management using voltage scaling technique with the aim to generate designs that are optimized in terms of power consumption, while providing acceptable application-level correctness and meeting real-time performance deadlines. We propose a novel voltage scaling technique based on linear programming capable of identifying the appropriate supply voltage and frequency values of the processing cores in an MPSoC such that the power consumption is minimized for a given soft error rate (SER) and a specified performance deadline. We evaluate the effectiveness of our technique using an MPEG-2 video decoder as a case study and with peak signal-to-noise ratio (PSNR) as the application-level correctness metric. We show that the proposed voltage scaling technique can achieve up to 85% power reduction for SER of 3.98E? 8, while maintaining acceptable levels of real-time performance (29 frames/s) and application-level correctness (30dB PSNR). The above case study is based on an MPSoC architecture with four processing cores. We have also investigated the effect of varying the number of processing cores (architecture allocation) and application task mapping (distribution of tasks among cores of the MPSoC architecture) on the trade-offs between application-level correctness and power consumption minimization using the proposed voltage scaling technique.
Survey of option pricing methods

This paper first introduces the emergence and development of option pricing theory, then gives a more detailed description of the theoretical and empirical researches on the method. In particular, we focus on the such methods as deterministic arbitrage, e arbitrage and interval pricing, with applications to both complete markets and incomplete markets. Finally,conditions and characteristics of the various option pricing methods are discussed.
Reporting, Reviewing, and Responding to Harassment on Twitter

When people experience harassment online, from individual threats or invective to coordinated campaigns of harassment, they have the option to report the harassers and content to the platform where the harassment has occurred. Platforms then evaluate harassment reports against terms of use and other policies to decide whether to remove content or take action against the alleged harasser — or not. On Twitter, harassing accounts can be deleted entirely, suspended (with content made unavailable pending appeal or specific changes), or sent a warning. Some platforms, including Twitter and YouTube, grant "authorized reporters" or "trusted flaggers" special privileges to identify and report inappropriate content on behalf of others.In November 2014, Twitter granted Women, Action, and the Media (WAM! ) this authorized reporter status. From November 6–26 2014, WAM! took in reports of Twitter-based harassment, assessed them, and escalated reports as necessary to Twitter for special attention. WAM! used a special intake form to collect data and promised publicly to publish what it learned from the data it collected. In three weeks, WAM! reviewers assessed 811 incoming reports of harassment and escalated 161 reports to Twitter, ultimately seeing Twitter carry out 70 account suspensions, 18 warnings, and one deleted account. This document presents findings from this three-week project; it draws on both quantitative and qualitative methods.Findings focus on the people reporting and receiving harassment, the kinds of harassment that were reported, Twitter’s response to harassment reports, the process of reviewing harassment reports, and challenges for harassment reporting processes.
Structure of the YibK methyltransferase from Haemophilus influenzae (HI0766): A cofactor bound at a site formed by a knot

The crystal structures of YibK from Haemophilus influenzae (HI0766) have been determined with and without bound cofactor product S‐adenosylhomocysteine (AdoHcy) at 1.7 and 2.0 Å resolution, respectively. The molecule adopts an α/β fold, with a topology that differs from that of the classical methyltransferases. Most notably, HI0766 contains a striking knot that forms the binding crevice for the cofactor. The knot formation is correlated with an alternative arrangement of the secondary structure units compared with the classical methyltransferases. Two loop regions undergo conformational changes upon AdoHcy binding. In contrast to the extended conformation of the cofactor seen in the classical methyltransferase structures, AdoHcy binds to HI0766 in a bent conformation. HI0766 and its close sequence relatives are all shorter versions of the more remotely related rRNA/tRNA methyltransferases of the spoU sequence family. We propose that the spoU sequence family contains the same core domain for cofactor binding as HI0766 but has an additional domain for substrate binding. The substrate‐binding domain is absent in HI0766 sequence family and may be provided by another Haemophilus influenzae partner protein, which is yet to be identified. Proteins 2003;51:56–67. © 2003 Wiley‐Liss, Inc.
Classification of voiceband data signals using the constellation magnitude

We discuss the real time classification of high speed (/spl ges/4800 b/s) voiceband data signals using blind or self-recovering equalization techniques. After equalization, the signals are classified, by means of their constellation magnitude, using a new classification scheme which computes the probability that the unknown test signal belongs to each of several predetermined classes. Heuristic rules are applied to these probability functions to perform the actual signal detection. Even in the presence of added channel impairments, the use of this new approach resulted in an overall classification accuracy of greater than 98%, measured using 5100 test segments collected from 6 classes of signals produced by V.29, V.32, and V.33 modems. Classification times range from median values of 0.090 s and 0.219 s for the V.29 modem at 4800 and 7200 b/s, respectively, up to a worse case time of 3.33 s for the 9600 b/s default class, chosen only if no other signal is detected within a prescribed amount of time.
Improved modelling of PMSMs taking into account conductive rotor parts

Permanent-magnet synchronous machines (PMSMs) are increasingly being used, not only in robotics but also in many other drives such as for traction, heat, ventilation and air-conditioning applications as an alternative for the induction machine. Advanced control of those PMSMs can require a machine model and a appropriate method to identify the model parameters. In conventional models, the only conductive part modelled is the stator winding. In this paper, a model for the PMSM is proposed that takes into account the conductive parts in the rotor as well, such as the electric steel laminations and the permanent magnets itself. These parts are represented by an equivalent winding. Further, the parameter identification of this model is discussed and the results are presented. As PMSMs operate at a variable magnetic state, the influence of magnetic saturation on the estimated electrical parameters is discussed.
Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium Fluctuations

Image brain function: Gd3+ chelates linked to a modified EGTA moiety were prepared in order to respond to extracellular Ca2+ fluctuations in the brain. Upon interaction with Ca2+, they exhibit high and reversible relaxivity changes in buffered solution or in a model of the brain extracellular medium. These efficient Ca2+ magnetic resonance imaging sensors might open new perspectives in functional molecular imaging.