Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical information systems in private hospitals

With the tremendous developments in Information Technology (IT), many organizations in private sectors use IT to transform their services and operation. Like any other sectors, the health sector has been benefited from the adoption of IT in transforming their services for society well-being. The applications of IT have greatly improved accessibility, quality and cost-effectiveness of healthcare. Clinical Information Systems (CIS) are one of the examples of the applications of IT in healthcare. CIS are computer applications that support the operations of clinicians engaged in providing care to patients. However, CIS does not always improve the outcomes and performance of the health professionals, but might bring about negative impacts on their performance and practices. Studies on medical errors have shown that errors in healthcare and medicine are not rare and may bring about severe harm to patients. This paper aims to understand the use of CIS in hospitals and their impact on patient safety. Using interviews with medical practitioners in private hospitals in Malaysia, the findings provide insights for system developers and hospital managers on the usability of CIS to ensure the delivery of better patient care since error reduction is one of the dimensions of health service quality.
Conformational changes induced in the protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides

A critical event in signaling in immune cells is the interaction of Syk or ZAP-70 protein tyrosine kinases with multisubunit receptors that contain an approximately 18-amino-acid domain called the immunoreceptor tyrosine-based activation motif (ITAM). Tyrosine-phosphorylated Syk from activated cells was in a conformation different from that in nonstimulated cells as demonstrated by changes in immunoreactivity. The addition of tyrosine-diphosphorylated ITAM peptides resulted in a similar conformational change in Syk from nonactivated cells. The peptides based on FcepsilonRIgamma were more active than those based on Fcepsilon RIbeta. In vitro autophosphorylation of Syk was dramatically enhanced by the addition of the diphosphorylated ITAM peptides. The conformational change and the enhanced autophosphorylation required the presence of both phosphorylated tyrosines on the same molecule. These conformational changes in Syk by tyrosine phosphorylation or binding to diphosphorylated ITAM could be critical for Syk activation and downstream propagation of intracellular signals.
Cloning and sequencing of a complementary DNA encoding a Mr 70,000 human breast epithelial mucin-associated antigen.

The human milk fat globule (HMFG) membrane contains several glycoproteins that have been referred to as breast differentiation antigens and that are expressed in normal breast, breast tumors, breast tumor-derived cell lines, and are found in breast cancer patient serum. These antigens include a high molecular weight mucin and several smaller components including Mr 150,000; 70,000; and 46,000 glycoproteins. We have used 2 monoclonal antibodies (McR2 and Mc13) that bind the Mr 70,000 component of HMFG to immunoscreen a lambda gt11 expression library prepared from human lactating breast tissue. We report here the sequence of a complementary DNA clone (BA70-1) that codes for a peptide that binds both McR2 and Mc13 but not monoclonal antibodies to the breast mucin or other components of HMFG.A 1.8-kilobase RNA was detected in 9 of 9 breast tumor cell lines using 32P-labeled BA70-1 as probe. The BA70-1 RNA was highly expressed in 6 of 9 cells lines of breast and several other carcinomas lines compared with a lymphoblastoid cell line (Raji). The BA70-1 complementary DNA sequence has no extensive homology with previously reported sequences including the high-molecular weight mucin complementary DNA. Since the Mr 70,000 molecule appears to be associated with the breast mucin by disulfide bonds, its study could help elucidate the structure of this latter complex and how it is organized in the cell membrane, and prove useful in diagnosis and therapy of breast cancer.
Research on Orthogonal Direction Algorithm Using Direction Error

For the orthogonal direction algorithm, the iteration direction is the direction vector, and the iteration error of the adaptive filter is caused by the input vector. These two directions are not the same one, which leads to more deviation for the iteration error. In this paper, an orthogonal direction algorithm using direction error is presented to settle this problem, which the iteration error is caused by the iteration direction. By setting the weight error to be zero in the direction vector, the optimal step-size is obtained, which improves the adaptive filtering convergence rate. DOI : http://dx.doi. org/10.11591/telkomnika.v12i2. 4216
Relationship between arterial stiffness assessed by brachial-ankle pulse wave velocity and coronary artery disease severity assessed by the SYNTAX score.

AIM The SYNTAX score is a semi-quantitative angiographic tool used to determine the extent and severity of coronary artery disease (CAD). Automatic computer-assisted measurement of the brachial-ankle pulse wave velocity (baPWV) is a reproducible and valid method by which to assess arterial stiffness. Limited information is available for the association between the SYNTAX score and arterial stiffness in a CAD patient. We aim to assess the association between arterial stiffness determined by PWV and CAD severity assessed by angiography and the SYNTAX score. METHODS 321 subjects underwent measurement of both baPWV and angiography from 2010 to 2011. BaPWV was divided into tertiles. Multiple logistic and linear regression analyses were used to evaluate the relationship between the SYNTAX score and baPWV. RESULTS After adjusting for age, body mass index, smoking habits, family history of CAD, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), total cholesterol, triglycerides, LDL-cholesterol, fasting glucose, serum creatinine, uric acid and cysteine proteinase, analyses revealed that baPWV groups were significantly associated with the SYNTAX score. Compared with the lowest baPWV tertile, the adjusted odds ratios (ORs) of having a SYNTAXHIG for the MID and HIG baPWV tertiles were 4.76 (95% confidence interval: 1.71-6.33) and 4.13 (95% confidence interval: 1.12-5.27), respectively. We also used multiple linear regression analyses to assess the association between baPWV and the SYNTAX score, which showed that baPWV was associated with the SYNTAX score. CONCLUSION Arterial stiffness determined by PWV is related to CAD severity assessed by angiography and the SYNTAX score.
Do repeated risk factor measurements influence the impact of education on cardiovascular mortality?

Objective It has been questioned if the excess cardiovascular disease (CVD) mortality by lower educational level can be fully explained by conventional modifiable CVD risk factors. Our objective was to examine whether repeated measures over time of risk factors (smoking, physical inactivity, blood pressure, total cholesterol and body mass index) explain more of the socioeconomic gradient in CVD mortality than if they are measured only once. Methods A cohort of 34 884 men and women attended all three screenings (1974–1978, 1977–1983 and 1985–1988) in the Norwegian Counties Study and were followed for CVD mortality through 2009 by linkage to the Norwegian Cause of Death Registry. Results Age-adjusted and sex-adjusted HR of CVD mortality was 2.32 (95% CI 1.93 to 2.80) for basic relative to tertiary educated individuals. The HR was attenuated by 48% (HR 1.54 (1.28 to 1.87)) when adjusted for CVD risk factors measured at baseline and by 56% (HR 1.45 (1.20 to 1.75)) when two repeated measurements ascertained 5 years apart were added to the model. Similarly, absolute risk difference in CVD mortality by education was attenuated by 62% when adjusted for baseline and by 72% when adjusted for repeated measurements of risk factors. Conclusions In this cohort, repeated measurements of risk factors seemed to explain more of the educational gradient in CVD mortality. This suggests that a substantial part of the excess CVD mortality among those with lower education might be explained by conventional risk factors.
Modelling wind farm with synthetic inertia for power system dynamic studies

The requirement to increase system wind power penetration while providing better frequency quality has necessitated the wind turbines to emulate inertial response of the classical synchronous generators. This paper presents a simulation study done in order to understand the main factors that affect the potential for inertia emulation in a variable speed variable pitch wind turbine. A small power system consisting of three synchronous generators and one wind farm is modelled. Dynamic models are applied for all components in order to gain a more realistic understanding of the underlying phenomenon. The results show how the applied inertia emulation scheme influences the operation of the wind turbine. It is found that while the inertia time constant dominates inertia emulation in an under frequency event, the dynamics of the pitching system dominates inertia emulation in an over frequency event. The study provides an insight into how to design the inertia controller.
RGS3 and RGS4 Differentially Associate with G Protein-coupled Receptor-Kir3 Channel Signaling Complexes Revealing Two Modes of RGS Modulation

RGS3 and RGS4 are GTPase-activating proteins expressed in the brain and heart that accelerate the termination of Gi/o- and Gq-mediated signaling. We report here the determinants mediating selective association of RGS4 with several G protein-coupled receptors (GPCRs) that form macromolecular complexes with neuronal G protein-gated inwardly rectifying potassium (Kir3 or GIRK) channels. Kir3 channels are instrumental in regulating neuronal firing in the central and peripheral nervous system and pacemaker activity in the heart. By using an epitope-tagged degradation-resistant RGS4 mutant, RGS4(C2V), immunoprecipitation of several hemagglutinin-tagged Gi/o-coupled and Gq-coupled receptors expressed in Chinese hamster ovary (CHO-K1) cells readily co-precipitated both Kir3.1/Kir3.2a channels and RGS4(C2V). In contrast to RGS4(C2V), the closely related and functionally active RGS3 “short” isoform (RGS3s) did not interact with any of the GPCR-Kir3 channel complexes examined. Deletion and chimeric RGS constructs indicate both the N-terminal domain and the RGS domain of RGS4(C2V) are necessary for association with m2 receptor-Kir3.1/Kir3.2a channel complexes, where the GPCR was found to be the major target for RGS4(C2V) interaction. The functional impact of RGS4(C2V) “precoupling” to the GPCR-Kir3 channel complex versus RGS3s “collision coupling” was a 100-fold greater potency in the acceleration of G protein-dependent Kir3 channel-gating kinetics with no attenuation in current amplitude. These findings demonstrate that RGS4, a highly regulated modulator and susceptibility gene for schizophrenia, can directly associate with multiple GPCR-Kir3 channel complexes and may affect a wide range of neurotransmitter-mediated inhibitory and excitatory events in the nervous and cardiovascular systems.
Dual capacitive-inductive nature of graphene metasurface: Transmission characteristics at low-terahertz frequencies

We report on the dual nature (capacitive and inductive) of the surface impedance of periodic graphene patches at low-terahertz frequencies. The transmission spectra of a graphene-dielectric stack shows that patterned graphene exhibits both the low-frequency (capacitive) passband of metal patch arrays and the higher-frequency (inductive) passband of metal aperture arrays in a single tunable configuration. The analysis is carried out using a transfer matrix approach with two-sided impedance boundary conditions, and the results are verified using full-wave numerical simulations.
A semi-active control strategy for vibration isolation to improve the ride comfort of vehicles

This paper proposes and studies a new hybrid semi-active control strategy based on the conventional Rakheja-Sankar (R-S) semi-active control to provide better ride-handling quality for vehicle suspension systems, as well as industrial vibration isolators. This study combines the effect of dampers asymmetry and conventional control strategies to achieve higher performance. A simple one-degree-of-freedom quarter-car model is adopted to study the proposed system. To demonstrate the effectiveness of this new strategy, the analytical method of averaging and the numerical analysis are deployed. In addition, a one-degree-of-freedom test bed equipped with a semi-active magnetorheological (MR) damper is developed. The analytical, numerical and experimental methods confirm the advantages of the proposed strategy over the passive system and the conventional control strategies. This new semi-active control strategy could be easily adopted to be used with most of the existing semi-active control systems, offering a higher level of performance with minimal changes.
Calcium‐activated non‐selective cation currents are involved in generation of tonic and bursting activity in dopamine neurons of the substantia nigra pars compacta

Non‐technical summary The loss of dopamine‐containing neurons within the substantia nigra has been implicated in Parkinson's disease. Thus, the question why these neurons are particularly vulnerable to excitotoxicity has received considerable attention. Under physiological conditions dopamine neurons can generate a burst of activity that seems to require NMDA receptors and that is activated by high frequency glutamatergic inputs. Here, we show in a brain slice preparation of mice that NMDA receptor activation further excites the neurons by recruiting a calcium‐activated non‐selective cation current (ICAN) and we hypothesize that ICAN is specifically mediated by a transient receptor potential (TRP) channel. We used RT‐PCR methods to confirm expression of TRPM2 and TRPM4 mRNA in substantia nigra pars compacta. We propose that ICAN is selectively activated during burst firing to boost NMDA currents and allow plateau potentials. This boost mechanism may render DA cells vulnerable to excitotoxicity.
Evaluation of recurrence in 36 subacute thyroiditis patients managed with prednisolone.

OBJECTIVE The incidence of subacute thyroiditis (SAT) is low and there are a few reports of recurrence of subacute thyroiditis. Current treatment protocols for SAT are not uniform. Prednisolone (PSL) is chosen more often for treatment than nonsteroidal anti-inflammatory drugs. This study was undertaken to confirm the recurrence rate of SAT managed by PSL, and to compare the initial laboratory data between the recurrent and the non-recurrent groups. METHODS After diagnosis, all patients were treated with PSL (starting at 30 mg or 25 mg per day, tapered by 5 mg per week) for 5 or 6 weeks. We evaluated data and symptoms at the first visit and during the therapy. PATIENTS Thirty-six patients who received only PSL for SAT at our hospital between January 1997 and December 1998 were referred. These patients asked to visit every 2 weeks for the monitoring of symptoms and laboratory data. RESULTS SAT symptoms recurred in eight patients (22%), most upon cessation of PSL. There was no difference in initial serum sialic acid, erythrocyte sedimentation rate, C-reactive protein, thyroglobulin, serum free thyroxine and free triiodothyronine before PSL treatment between the recurrent and non-recurrent patient populations. CONCLUSIONS The recurrence rate of SAT with treated PSL is about 20%. There was no difference in the laboratory data before starting the therapy between recurrent and non-recurrent groups. Therefore, a modified protocol of PSL administration may be needed to decrease the early recurrent rate of SAT.
Optical character recognition on grid and multi-core systems – performance analysis

Requirements of digital libraries for computing power, as well as needs of smaller users for automated document processing and digitization are growing, making grid environments and multi-core systems a preferred platform for optical character recognition applications. This paper examines character recognition performance on the CRO-NGI grid and on two multi-core systems by using from a single core up to all available cores. In addition, different models of load distribution on processing units are used. Comparison of the processing speed and the recognition accuracy is conducted. A developed optical character recognition application for parallel environments is used to obtain the results.
Association of size-resolved number concentrations of particulate matter with cardiovascular and respiratory hospital admissions and mortality in Prague, Czech Republic

We analyzed the association of particle number and PM2.5 concentrations with mortality and cardiorespiratory hospital admissions in Prague. Number concentrations of submicron particles in the range of 15–487 nm were measured continuously at a central site in 2006. The particle number concentrations were integrated into four groups with count median diameters of 31 (NC31), 128 (NC128), and 346 nm (NC346). The total number concentration of submicron particles 15–487 nm (NCtot) was also constructed. The studied health outcomes were the daily hospital admissions due to cardiovascular and respiratory diseases and daily cardiovascular and respiratory mortality and the total mortality. The Poisson regression was used for data analysis. The strongest association was found for the accumulation mode particles (NC346) (RR 1.164, 95% CI: 1.052–1.287 for cardiovascular and 1.334, 95% CI: 1.126–1.579 for respiratory admissions for a 7-day moving average for 1000 particles per 1 cm3 increase). Reasonable association between both the cardiovascular and respiratory admissions and NC346 was also found for lag 0, lag 1, lag 2 (not for respiratory admissions), and the 4-day moving average. For NC128 and NCtot, the association was also significant for both cardiovascular and respiratory admissions at lag 0, lag 1, and lag 2 (not for respiratory admissions) for the 4-day and 7-day moving average. The association between the PM2.5 and daily cardiovascular hospital admissions was significant at 2-day lag and for a 4-day average. Positive association with respiratory admissions was significant only for a 7-day average. No association was found between the studied air pollution variables and daily mortality.
An adaptive map-matching algorithm based on hierarchical fuzzy system from vehicular GPS data

An improved hierarchical fuzzy inference method based on C-measure map-matching algorithm is proposed in this paper, in which the C-measure represents the certainty or probability of the vehicle traveling on the actual road. A strategy is firstly introduced to use historical positioning information to employ curve-curve matching between vehicle trajectories and shapes of candidate roads. It improves matching performance by overcoming the disadvantage of traditional map-matching algorithm only considering current information. An average historical distance is used to measure similarity between vehicle trajectories and road shape. The input of system includes three variables: distance between position point and candidate roads, angle between driving heading and road direction, and average distance. As the number of fuzzy rules will increase exponentially when adding average distance as a variable, a hierarchical fuzzy inference system is then applied to reduce fuzzy rules and improve the calculation efficiency. Additionally, a learning process is updated to support the algorithm. Finally, a case study contains four different routes in Beijing city is used to validate the effectiveness and superiority of the proposed method.
Characterization of proteins in the gonad of Limanda yokohamae from Masan Bay, Korea

The putative biological effects of the toxic organic pollutants polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and the dioxin-like polychlorinated biphenyls (DLPCBs) in the sediments of Masan Bay, Korea, on the gonad of Limanda yokohamae were investigated using proteomic and bioinformatic analyses. The results demonstrated that 11 protein spots from the bay site, Duckdong, were statistically different from the reference site Gaduck Island. We identified 20 proteins from the 11 altered protein spots and these were found to be involved in multi-cellular functions as previously demonstrated in a variety of species. The concentrations of toxic equivalents of PCDD/Fs and DLPCBs in the sediments of Masan Bay were approximately twenty six-fold higher than those from Gaduck Island. These findings indicate that the organic contaminants in the sediments of Masan Bay may have contributed to the change in the phenotypes of fish gonads.
Identification of three amino acid residues in the B subunit of Shiga toxin and Shiga-like toxin type II that are essential for holotoxin activity

Shiga toxin of Shigella dysenteriae type I and Shiga-like toxins I and II (SLT-I and SLT-II, respectively) of enterohemorrhagic Escherichia coli are functionally similar protein cytotoxins. These toxin molecules have a bipartite molecular structure which consists of an enzymatically active A subunit that inhibits protein synthesis in eukaryotic cells and an oligomeric B subunit that binds to globotriaosylceramide glycolipid receptors on eukaryotic cells. Regionally directed chemical mutagenesis of the B subunit of SLT-II was used to identify amino acids in the B subunit that are critical for SLT-II holotoxin cytotoxic activity. Three noncytotoxic mutants were isolated, and their mutations were mapped. The substitutions of arginine with cysteine at codon 32, alanine with threonine at codon 42, and glycine with aspartic acid at codon 59 in the 70-amino-acid mature SLT-II B polypeptide resulted in the complete abolition of cytotoxicity. The analogous arginine, alanine, and glycine residues were conserved at codons 33, 43, and 60 in the 69-amino-acid mature B polypeptide of Shiga toxin. Comparable mutations induced in the B-subunit gene of Shiga toxin by oligonucleotide-directed, site-specific mutagenesis resulted in drastically decreased cytotoxicity (10(3)- to 10(6)-fold) as compared with that of wild-type Shiga toxin. The mutant SLT-II and Shiga toxin B subunits were characterized for stability, receptor binding, immunoreactivity, and ability to be assembled into holotoxin.
Traffic-Aware Micro Base Station Planning in Wireless Cellular Networks

Micro base station (BS) is introduced to the cellular network to improve both system capacity and energy efficiency. This paper develops a traffic-aware micro BSs planning scheme that takes both physical and traffic layer characteristics into account. We formulate a general problem, which is a challenging combinatorial problem, pertaining to total BS number minimization while satisfying the requirement of inhomogeneous traffic in the network. To solve the problem efficiently, we propose a greedy algorithm which is shown to be a constant-factor approximation of optimal deployment under the proven of the submodularity of a function related with the system capacity. Extensive simulations under various traffic configurations demonstrate the performance of the proposed algorithm and potential performance gains that can be achieved.