Miracle-dz/UniFAR-FTUs huggingface dataset:
Seven-level reduced flying capacitor inverter with improved harmonic distortion using hybrid phase-shifted carrier phase-disposition PWM

This paper proposes a simple modulation technique and a hybrid carrier-based PWM named as phase-shifted carrier phase-disposition PWM (PSC-PD-PWM) to reduce the switching states and the overall switching frequency of the state-of-art multiceli inverter. By doing so, higher number of output phase voltage levels can be synthesized with the number of flying capacitors and power semiconductor switches significantly reduced. Hence, a lower cost and lighter weight of reduced flying capacitor inverter (RFCI) is achieved as compared to the classical multilevel flying capacitor inverter (MFCI) based on phase-shifted carrier PWM (PSC-PWM). On top ofthat, the total harmonic distortion (THD) performance is found to be improved in RFCI with the proposed hybrid PSC-PD-PWM especially for the synthesized output line-to-line voltages. Comparative studies of MFCI and RFCI are discussed in this paper and highlighted the improvements made. In addition to that, the performance of the proposed RFCI with PSC-PD-PWM is evaluated under dynamic conditions. Results have proven the feasibility of the RFCI concepts with the proposed hybrid PSC-PD-PWM.
Acute oral dose of sodium nitrite causes redox imbalance and DNA damage in rat kidney

Sodium nitrite (NaNO2) is widely used as a food additive and preservative in fish and meat products. We have evaluated the effect of a single acute oral dose of NaNO2 on oxidative stress parameters, antioxidant capacity, and DNA in rat kidney. Male Wistar rats were divided into four groups and given single oral dose of NaNO2 at 20, 40, 60, and 75 mg/kg body weight; untreated rats served as the control group. All animals in NaNO2‐treated groups showed marked alterations in various parameters of oxidative stress as compared to the control group. This included increase in lipid peroxidation, protein oxidation, hydrogen peroxide levels, and decrease in reduced glutathione content and antioxidant capacity. Administration of NaNO2 also increased DNA damage as evident from release of free nucleotides and confirmed by comet assay. It also led to greater cross‐linking of DNA to proteins. Histological analysis showed marked morphological changes in the kidney of NaNO2‐treated animals. These alterations could be due to increased free radical generation or direct chemical modification by reaction intermediates. Our results suggest that nitrite‐induced nephrotoxicity is mediated through redox imbalance and results in DNA damage.
Increase in Tomato Locule Number Is Controlled by Two Single-Nucleotide Polymorphisms Located Near WUSCHEL1[C][W]

In tomato (Solanum lycopersicum) fruit, the number of locules (cavities containing seeds that are derived from carpels) varies from two to up to 10 or more. Locule number affects fruit shape and size and is controlled by several quantitative trait loci (QTLs). The large majority of the phenotypic variation is explained by two of these QTLs, fasciated (fas) and locule number (lc), that interact epistatically with one another. FAS has been cloned, and mutations in the gene are described as key factors leading to the increase in fruit size in modern varieties. Here, we report the map-based cloning of lc. The lc QTL includes a 1,600-bp region that is located 1,080 bp from the 3′ end of WUSCHEL, which encodes a homeodomain protein that regulates stem cell fate in plants. The molecular evolution of lc showed a reduction of diversity in cultivated accessions with the exception of two single-nucleotide polymorphisms. These two single-nucleotide polymorphisms were shown to be responsible for the increase in locule number. An evolutionary model of locule number is proposed herein, suggesting that the fas mutation appeared after the mutation in the lc locus to confer the extreme high-locule-number phenotype.
Simvastatin-induced sphingosine 1−phosphate receptor 1 expression is KLF2-dependent in human lung endothelial cells

We have demonstrated that simvastatin and sphingosine 1−phosphate (S1P) both attenuate increased vascular permeability in preclinical models of acute respiratory distress syndrome. However, the underlying mechanisms remain unclear. As Krüppel-like factor 2 (KLF2) serves as a critical regulator for cellular stress response in endothelial cells (EC), we hypothesized that simvastatin enhances endothelial barrier function via increasing expression of the barrier-promoting S1P receptor, S1PR1, via a KLF2-dependent mechanism. S1PR1 luciferase reporter promoter activity in human lung artery EC (HPAEC) was tested after simvastatin (5 μM), and S1PR1 and KLF2 protein expression detected by immunoblotting. In vivo, transcription and expression of S1PR1 and KLF2 in mice lungs were detected by microarray profiling and immunoblotting after exposure to simvastatin (10 mg/kg). Endothelial barrier function was measured by trans-endothelial electrical resistance with the S1PR1 agonist FTY720-(S)-phosphonate. Both S1PR1 and KLF2 gene expression (mRNA, protein) were significantly increased by simvastatin in vitro and in vivo. S1PR1 promoter activity was significantly increased by simvastatin (P < 0.05), which was significantly attenuated by KLF2 silencing (siRNA). Simvastatin induced KLF2 recruitment to the S1PR1 promoter, and consequently, significantly augmented the effects of the S1PR1 agonist on EC barrier enhancement (P < 0.05), which was significantly attenuated by KLF2 silencing (P < 0.05). These results suggest that simvastatin upregulates S1PR1 transcription and expression via the transcription factor KLF2, and consequently augments the effects of S1PR1 agonists on preserving vascular barrier integrity. These results may lead to novel combinatorial therapeutic strategies for lung inflammatory syndromes.
Evaluation of the Sketch Engine Thesaurus on Analogy Queries

Recent research on vector representation of words in texts bring new methods of evaluating distributional thesauri. One of such methods is the task of analogy queries. We evaluated the Sketch Engine thesaurus on a subset of analogy queries using several similarity options. We show that Jaccard similarity is better than the cosine one for bigger corpora, it even substantially outperforms the word2vec system.
On the Smallest Enclosing Balls

In the paper a theoretical analysis is given for the smallest ball that covers a finite number of points p1, p2,··· , pN 2 R n . Several fundamental properties of the smallest enclosing ball are described and proved. Particularly, it is proved that the k-circumscribing enclosing ball with smallest k is the smallest enclosing ball, which dramatically reduces a possible large number of computations in the higher dimensional case. General formulas are deduced for calculating circum- scribing balls. The difficulty of the closed-form description is discussed. Finally, as an application, the problem of finding a common quadratic Lyapunov function for a set of stable matrices is consid- ered.
Ordinal probability effect measures for group comparisons in multinomial cumulative link models

We consider simple ordinal model‐based probability effect measures for comparing distributions of two groups, adjusted for explanatory variables. An “ordinal superiority” measure summarizes the probability that an observation from one distribution falls above an independent observation from the other distribution, adjusted for explanatory variables in a model. The measure applies directly to normal linear models and to a normal latent variable model for ordinal response variables. It equals Φ(β/2) for the corresponding ordinal model that applies a probit link function to cumulative multinomial probabilities, for standard normal cdf Φ and effect β that is the coefficient of the group indicator variable. For the more general latent variable model for ordinal responses that corresponds to a linear model with other possible error distributions and corresponding link functions for cumulative multinomial probabilities, the ordinal superiority measure equals exp(β)/[1+exp(β)] with the log–log link and equals approximately exp(β/2)/[1+exp(β/2)] with the logit link, where β is the group effect. Another ordinal superiority measure generalizes the difference of proportions from binary to ordinal responses. We also present related measures directly for ordinal models for the observed response that need not assume corresponding latent response models. We present confidence intervals for the measures and illustrate with an example.
Could late measurement of serum creatinine be missed for patients without early increase in serum creatinine following coronary angiography?

Abstract Most patients are discharged early (within 24 hours) after coronary angiography (CAG) and may miss identification the late (24–48 hours) increase in serum creatinine (SCr), whose characteristics and prognosis have been less intensively investigated. We prospectively recruited 3065 consecutive patients with SCr measurement, including only1344 patients with twice SCr measurement (both early and late). The late contrast-induced acute kidney injury (CI-AKI) was defined as significantly increase in SCr (≥0.3 mg/dL or ≥50%) not in early phase, but only in late phase after the procedure, and the early CI-AKI experienced a significantly increase in early phase. Overall, CI-AKI developed in 134 patients (10%), and the incidence of late and early CI-AKI were 3.6% and 6.4%, respectively. There were no difference in age, renal, and heart function, contrast volume among patients with late and early CI-AKI. With mean follow-up period of 2.45 years, long-term mortality (3 years, 29.7% and 35.6%, respectively, P = .553) was similar for patients with late and early CI-AKI. Cox analysis showed that both late (adjusted HR 2.05; 95% CI, 1.02–4.15) and early (adjusted HR 2.68; 95% CI, 1.57–4.59) CI-AKI was significantly associated with long-term mortality (all P < .001). Only late increase in SCr, as late CI-AKI, accounted for about one-third of CI-AKI incidence and has similar good predictive value for long-term mortality with that of an early increase, early CI-AKI, among patients with SCr measured twice, supporting the importance of late repeating SCr measurement after CAG, even without an early significant increase in SCr.
A Long-Distance RF-Powered Sensor Node with Adaptive Power Management for IoT Applications

We present a self-sustained battery-less multi-sensor platform with RF harvesting capability down to −17 dBm and implementing a standard DASH7 wireless communication interface. The node operates at distances up to 17 m from a 2 W UHF carrier. RF power transfer allows operation when common energy scavenging sources (e.g., sun, heat, etc.) are not available, while the DASH7 communication protocol makes it fully compatible with a standard IoT infrastructure. An optimized energy-harvesting module has been designed, including a rectifying antenna (rectenna) and an integrated nano-power DC/DC converter performing maximum-power-point-tracking (MPPT). A nonlinear/electromagnetic co-design procedure is adopted to design the rectenna, which is optimized to operate at ultra-low power levels. An ultra-low power microcontroller controls on-board sensors and wireless protocol, to adapt the power consumption to the available detected power by changing wake-up policies. As a result, adaptive behavior can be observed in the designed platform, to the extent that the transmission data rate is dynamically determined by RF power. Among the novel features of the system, we highlight the use of nano-power energy harvesting, the implementation of specific hardware/software wake-up policies, optimized algorithms for best sampling rate implementation, and adaptive behavior by the node based on the power received.
A new conception for enhancement of fatigue life of large number of fastener holes in aircraft structures

A new conception for increasing fatigue life of large number of fastener holes in aircraft structures is developed. It is accomplished by a new method, called friction stir hole expansion (FSHE). This method not only reduces labour and time consumption, but it also decreases the overall cost for processing a large number of holes in structures made of aerospace grade 2024-T3 aluminium alloy. FSHE combines the advantages of friction stir processing with these of mandrel cold working methods in two ways: a micro effect, expressed in hole surface modification, and a macro effect, expressed by the introduction of beneficial compressive residual macro stresses. The effectiveness of the method has been assessed by fatigue tests. Finite element simulations have been carried out. It has been proven that the greater fatigue life of fastener holes, processed by FSHE, is a consequence of the obtained micro effect.
Determination of Chloride Content in Cementitious Materials: From Fundamental Aspects to Application of Ag/AgCl Chloride Sensors

This paper reports on the advantages and drawbacks of available test methods for the determination of chloride content in cementitious materials in general, and the application of Ag/AgCl chloride sensors in particular. The main factors that affect the reliability of a chloride sensor are presented. The thermodynamic behaviour of silver in the presence or absence of chloride ions is described and kinetic restrictions are addressed. The parameters that can affect the activity of chloride ions in the medium and/or the rate of ion exchange and dissolution/precipitation processes at the sensor’s surface are also considered. In this regard, the contribution of morphology and microstructure of the AgCl layer, binding of chloride ions and the compactness of hydration products around the chloride sensor are highlighted. The important parameters for a reliable sensor’s response are discussed and the possible causes of inaccuracies are evaluated.
Clinical features associated with increased severity of illness in tertiary clinic referred patients with obsessive compulsive disorder

Abstract Objective: Obsessive-compulsive disorder (OCD) is a prevalent and disabling condition. Specific patterns of psychiatric comorbidity, early age at onset, long duration of illness (DI) and untreated illness (DUI) have been associated with poor outcome in OCD. The present study was aimed to explore sociodemographic and clinical characteristics associated with increased severity of illness in a sample of OCD patients. Methods: A total of 124 OCD outpatients were recruited and divided into two groups on the basis of their severity of illness, as assessed through the Yale-Brown Obsessive Compulsive Scale (>24). Chi-squared test and t-test for independent samples were performed to compare sociodemographic and clinical variables between the two groups. Results: The group with increased severity of illness had a younger age, an earlier age at onset and age at first pharmacological treatment (p < .05). In addition, the same group showed a longer DI but a shorter DUI (p < .01). Moreover, significantly higher rates of psychiatric comorbidities (p < .01) were observed in the higher severity group. Conclusions: Earlier age, age at onset and age at first pharmacological treatment, longer DI, shorter DUI and higher rate of psychiatric comorbidities were associated with increased severity of OCD. Further studies on larger samples are warranted to confirm the reported results.
A Real-Time Contactless Pulse Rate and Motion Status Monitoring System Based on Complexion Tracking

Subject movement and a dark environment will increase the difficulty of image-based contactless pulse rate detection. In this paper, we detected the subject’s motion status based on complexion tracking and proposed a motion index (MI) to filter motion artifacts in order to increase pulse rate measurement accuracy. Additionally, we integrated the near infrared (NIR) LEDs with the adopted sensor and proposed an effective method to measure the pulse rate in a dark environment. To achieve real-time data processing, the proposed framework is constructed on a Field Programmable Gate Array (FPGA) platform. Next, the instant pulse rate and motion status are transmitted to a smartphone for remote monitoring. The experiment results showed the error of the pulse rate detection to be within −3.44 to +4.53 bpm under sufficient ambient light and −2.96 to + 4.24 bpm for night mode detection, when the moving speed is higher than 14.45 cm/s. These results demonstrate that the proposed method can improve the robustness of image-based contactless pulse rate detection despite subject movement and a dark environment.
Learning gene regulatory networks from next generation sequencing data

In recent years, next generation sequencing (NGS) has gradually replaced microarray as the major platform in measuring gene expressions. Compared to microarray, NGS has many advantages, such as less noise and higher throughput. However, the discreteness of NGS data also challenges the existing statistical methodology. In particular, there still lacks an appropriate statistical method for reconstructing gene regulatory networks using NGS data in the literature. The existing local Poisson graphical model method is not consistent and can only infer certain local structures of the network. In this article, we propose a random effect model‐based transformation to continuize NGS data and then we transform the continuized data to Gaussian via a semiparametric transformation and apply an equivalent partial correlation selection method to reconstruct gene regulatory networks. The proposed method is consistent. The numerical results indicate that the proposed method can lead to much more accurate inference of gene regulatory networks than the local Poisson graphical model and other existing methods. The proposed data‐continuized transformation fills the theoretical gap for how to transform discrete data to continuous data and facilitates NGS data analysis. The proposed data‐continuized transformation also makes it feasible to integrate different types of data, such as microarray and RNA‐seq data, in reconstruction of gene regulatory networks.
Transcriptomic analysis reveals the roles of gibberellin-regulated genes and transcription factors in regulating bolting in lettuce (Lactuca sativa L.)

A cool temperature is preferred for lettuce cultivation, as high temperatures cause premature bolting. Accordingly, exploring the mechanism of bolting and preventing premature bolting is important for agriculture. To explore this relationship in depth, morphological, physiological, and transcriptomic analyses of the bolting-sensitive line S39 at the five-leaf stage grown at 37°C were performed in the present study. Based on paraffin section results, we observed that S39 began bolting on the seventh day at 37°C. During bolting in the heat-treated plants, GA3 and GA4 levels in leaves and the indoleacetic acid (IAA) level in the stem reached a maximum on the sixth day, and these high contents were maintained. Additionally, bolting begins in the fifth day after GA3 treatment in S39 plants, GA3 and GA4 increased and then decreased, reaching a maximum on the fourth day in leaves. Similarly, IAA contents reached a maximum in the stem on the fifth day. No bolting was observed in the control group grown at 25°C, and significant changes were not observed in GA3 and GA4 levels in the controls during the observation period. RNA-sequencing data implicated transcription factors (TFs) in regulating bolting in lettuce, suggesting that the high GA contents in the leaves and IAA in the stem promote bolting. TFs possibly modulate the expression of related genes, such as those encoding hormones, potentially regulating bolting in lettuce. Compared to the control group, 258 TFs were identified in the stem of the treatment group, among which 98 and 156 were differentially up- and down-regulated, respectively; in leaves, 202 and 115 TFs were differentially up- and down-regulated, respectively. Significant changes in the treated group were observed for C2H2 zinc finger, AP2-EREBP, and WRKY families, indicating that these TFs may play important roles in regulating bolting.
Hybrid Signal Processing Technique to Improve the Defect Estimation in Ultrasonic Non-Destructive Testing of Composite Structures

This work proposes a novel hybrid signal processing technique to extract information on disbond-type defects from a single B-scan in the process of non-destructive testing (NDT) of glass fiber reinforced plastic (GFRP) material using ultrasonic guided waves (GW). The selected GFRP sample has been a segment of wind turbine blade, which possessed an aerodynamic shape. Two disbond type defects having diameters of 15 mm and 25 mm were artificially constructed on its trailing edge. The experiment has been performed using the low-frequency ultrasonic system developed at the Ultrasound Institute of Kaunas University of Technology and only one side of the sample was accessed. A special configuration of the transmitting and receiving transducers fixed on a movable panel with a separation distance of 50 mm was proposed for recording the ultrasonic guided wave signals at each one-millimeter step along the scanning distance up to 500 mm. Finally, the hybrid signal processing technique comprising the valuable features of the three most promising signal processing techniques: cross-correlation, wavelet transform, and Hilbert–Huang transform has been applied to the received signals for the extraction of defects information from a single B-scan image. The wavelet transform and cross-correlation techniques have been combined in order to extract the approximated size and location of the defects and measurements of time delays. Thereafter, Hilbert–Huang transform has been applied to the wavelet transformed signal to compare the variation of instantaneous frequencies and instantaneous amplitudes of the defect-free and defective signals.
Using step width to compare locomotor biomechanics between extinct, non-avian theropod dinosaurs and modern obligate bipeds

How extinct, non-avian theropod dinosaurs locomoted is a subject of considerable interest, as is the manner in which it evolved on the line leading to birds. Fossil footprints provide the most direct evidence for answering these questions. In this study, step width—the mediolateral (transverse) distance between successive footfalls—was investigated with respect to speed (stride length) in non-avian theropod trackways of Late Triassic age. Comparable kinematic data were also collected for humans and 11 species of ground-dwelling birds. Permutation tests of the slope on a plot of step width against stride length showed that step width decreased continuously with increasing speed in the extinct theropods (p < 0.001), as well as the five tallest bird species studied (p < 0.01). Humans, by contrast, showed an abrupt decrease in step width at the walk–run transition. In the modern bipeds, these patterns reflect the use of either a discontinuous locomotor repertoire, characterized by distinct gaits (humans), or a continuous locomotor repertoire, where walking smoothly transitions into running (birds). The non-avian theropods are consequently inferred to have had a continuous locomotor repertoire, possibly including grounded running. Thus, features that characterize avian terrestrial locomotion had begun to evolve early in theropod history.
Neutrophil-Associated Central Nervous System Inflammation in Tuberculous Meningitis Immune Reconstitution Inflammatory Syndrome

Tuberculous meningitis immune reconstitution inflammatory syndrome (TBM-IRIS) is characterized by severe, compartmentalized cerebral inflammation, involving mediators of innate and adaptive immune responses. A high baseline cerebrospinal fluid bacillary load predisposes to recurrent inflammation during antiretroviral therapy, manifesting as TBM-IRIS.