Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute myeloid leukemia with translocation t ( 3 ; 5 ) : new molecular insight by

Publisher's Disclaimer. E-publishing ahead of print is increasingly important for the rapid dissemination of science. Haematologica is, therefore, E-publishing PDF files of an early version of manuscripts that have completed a regular peer review and have been accepted for publication. E-publishing of this PDF file has been approved by the authors. After having E-published Ahead of Print, manuscripts will then undergo technical and English editing, typesetting, proof correction and be presented for the authors' final approval; the final version of the manuscript will then appear in print on a regular issue of the journal. All legal disclaimers that apply to the journal also pertain to this production process.
INFLUENCE OF MISSING DATA IMPUTATION METHOD ON THE CLASSIFICATION ACCURACY OF THE MEDICAL DATA

Aim of this study is to show the dangers of filling missing data particularly medical data. Because there are many dedicated medical expert systems and medical decision support systems, a special attention must be paid on the construction of classifiers. Medical data are almost never complete, and completion of the missing data requires a special care. The safest approach of dealing with missing data would be removing records with missing parameters and/or removing parameters that are missing in the records. Unfortunately reducing data set that is already very small is not always an option. Dangers coming out from data imputation are shown in the article, which presents the influence of selected missing data filling algorithms on the classification accuracy.
Physical activity and epithelial ovarian cancer risk: A case‐control study in China

A case‐control study was conducted in China during 1999–2000 to investigate the effects of intensity and duration of physical activity on the risk of epithelial ovarian cancer. Cases were 254 patients with histologically confirmed epithelial ovarian cancer. The 652 controls comprised 340 hospital visitors, 261 non‐neoplasm hospital outpatients and 51 women recruited from the community. Physical activity was measured by a validated questionnaire. The risks of ovarian cancer were assessed using multivariate logistic regression analysis accounting for age, demographic, lifestyle and familial factors, hormonal status, family ovarian cancer history and total energy intake. The study found that increasing total physical activity was associated with a lower ovarian cancer risk among Chinese women. The odds ratio was 0.54 (95% CI 0.34–0.87) for high vs. low levels of total weekly metabolic equivalent tasks. Ovarian cancer risk tended to decline with increasing duration of strenuous sports and frequency of activity‐induced sweating among pre‐menopausal women, with adjusted OR 0.13 (95% CI 0.03–0.64) and 0.45 (95% CI 0.24–0.85), respectively. Increasing duration of moderate activity in post‐menopausal women also appeared to be protective against ovarian cancer, with adjusted OR 0.36 (95% CI 0.18–0.73). © 2003 Wiley‐Liss, Inc.
The morphology of the human lymphatic vessels in the head and neck

Previously little has been written about the morphology of the human lymphatic vessels since Sappey (Sappey [ 1874 ] Anatomie, Physiologie, Pathologie des Vaisseaux Lymphatiques, Paris: Adrien Delahaye) over 100 years ago. There needs to be an accurate re‐evaluation of scientific observations to aid clinical management. Forty‐nine combinations of tissue from the head and neck of 20 unembalmed human cadavers were studied. Six percent hydrogen peroxide was used to find the vessels. They were injected with radio‐opaque mixture, dissected, photographed, and radiographed. Final results were transferred to the computer for analysis. Different sized lymphatic valves were found in the precollecting and collecting lymph vessels, the lymphatic trunks, and ducts. The intervals between the valves were of various lengths. Diverse lymphatic ampullae and diverticula were seen in precollecting and collecting lymph vessels. Initial lymph vessels arose from the dermis, the galea, and the mucosal membrane. The vasculature of the direct and indirect precollecting and collecting lymph vessels, lymphatic trunks, and ducts was recorded. The morphology of the human lymphatic vessels in the head and neck has been described and recorded using radiographs and photographs. Clin. Anat. 23:654–661, 2010. © 2010 Wiley‐Liss, Inc.
Molecular Identification of Oligoalginate Lyase ofSphingomonas sp. Strain A1 as One of the Enzymes Required for Complete Depolymerization of Alginate

ABSTRACT A bacterium, Sphingomonas sp. strain A1, can incorporate alginate into cells through a novel ABC (ATP-binding cassette) transporter system specific to the macromolecule. The transported alginate is depolymerized to di- and trisaccharides by three kinds of cytoplasmic alginate lyases (A1-I [66 kDa], A1-II [25 kDa], and A1-III [40 kDa]) generated from a single precursor through posttranslational autoprocessing. The resultant alginate oligosaccharides were degraded to monosaccharides by cytoplasmic oligoalginate lyase. The enzyme and its gene were isolated from the bacterial cells grown in the presence of alginate. The purified enzyme was a monomer with a molecular mass of 85 kDa and cleaved glycosidic bonds not only in oligosaccharides produced from alginate by alginate lyases but also in polysaccharides (alginate, polymannuronate, and polyguluronate) most efficiently at pH 8.0 and 37°C. The reaction catalyzed by the oligoalginate lyase was exolytic and thought to play an important role in the complete depolymerization of alginate in Sphingomonas sp. strain A1. The gene for this novel enzyme consisted of an open reading frame of 2,286 bp encoding a polypeptide with a molecular weight of 86,543 and was located downstream of the genes coding for the precursor of alginate lyases (aly) and the ABC transporter (algS,algM1, and algM2). This result indicates that the genes for proteins required for the transport and complete depolymerization of alginate are assembled to form a cluster.
Algorithm selection of reinforcement learning algorithms

Dialogue systems rely on a careful reinforcement learning (RL) design: the learning algorithm and its state space representation. In lack of more rigorous knowledge, the designer resorts to its practical experience to choose the best option. In order to automate and to improve the performance of the aforementioned process, this article tackles the problem of online RL algorithm selection. A meta-algorithm is given for input a portfolio constituted of several off-policy RL algorithms. It then determines at the beginning of each new trajectory, which algorithm in the portfolio is in control of the behaviour during the next trajectory, in order to maximise the return. The article presents a novel meta-algorithm, called Epochal Stochastic Bandit Algorithm Selection (ESBAS). Its principle is to freeze the policy updates at each epoch, and to leave a rebooted stochastic bandit in charge of the algorithm selection. The algorithm comes with theoretical guarantees and proves to be practically efficient on a simulated dialogue task, even outperforming the best algorithm in the portfolio in most settings.
Mirtazapine in social anxiety disorder: a pilot study

Fourteen patients with social anxiety disorder (generalized type), according to DSM-IV criteria, were treated with mirtazapine 30 mg for 12 weeks. Twelve patients completed the study. Two patients (14.3%) dropped out due to side-effects. Generally, mirtazapine was well tolerated. Five out of 12 patients (41.7%) were classified as responders, based on a Clinical Global Improvement score of 1 or 2 and a reduction of the Liebowitz Social Anxiety Scale (LSAS) of 40%. The mean total score on the LSAS, as well as the anxiety and avoidance subscores, decreased significantly. This open pilot study suggests that further investigations are warranted to prove the efficacy of mirtazapine in generalized social anxiety disorder.
Interactive spatial copy wall for embodied interaction in a virtual co-existing space

A significance of a sense of togetherness or co-existence among remote communication partners has been pointed out in computer mediated communication area. In order to create such a co-existing situation, the presence of remote partners should be expressed at each place. In this paper, we propose a novel tangible human avatar display for remote interpersonal communication based on an idea integrating a video avatar expressing the fidelity of the embodiment, with a robot avatar as the physical presence. As a result, we devised "interactive spatial copy wall" ("ISCW") system, which represents a three-dimensional shape of remote partners with hundreds of movable pipes and remote participants can interact with each other by operating these movable pipes. We design this system based on modularity and we construct "ISCW" system of 192 cylinder modules. At the end, we discuss a possibility of this tangible avatar display when compared to the previous communication systems.
A comparative study of ofloxacin and cefixime for treatment of typhoid fever in children. The Dong Nai Pediatric Center Typhoid Study Group.

BACKGROUND Despite concerns about safety in children, fluoroquinolone antibiotics have become the treatment of choice in patients with multidrug-resistant typhoid fever in Vietnam. However, quinolone-resistant strains of Salmonella typhi have recently been reported from Vietnam; and if quinolone resistance becomes established, alternative oral treatment options will be needed. OBJECTIVE Cefixime, an orally administered third generation cephalosporin, was compared with ofloxacin for the treatment of uncomplicated typhoid fever in children. METHODS In an open trial children with suspected typhoid fever were randomized to receive either ofloxacin (10 mg/kg/day in two divided doses) for 5 days or cefixime (20 mg/kg/day in two divided doses) for 7 days. RESULTS S. typhi was isolated from 82 patients (44 in the cefixime group, 38 in the ofloxacin group) and 70 (85%) of the isolates were multidrug-resistant. Median (95% confidence interval, range) fever clearance times were 4.4 (4 to 5.2, 0.2 to 9.9) days for ofloxacin recipients and 8.5 (4.2 to 9, 1.8 to 15.2) days for cefixime-treated patients (P < 0.0001). There were 11 treatment failures (10 acute and one relapse) in the cefixime group and 1 acute treatment failure in the ofloxacin group (mean difference, 22%; 95% confidence interval, 9 to 36%). CONCLUSION Short course treatment with cefixime may provide a useful alternative treatment in cases of uncomplicated typhoid fever in children, but it is less effective than short course treatment with ofloxacin.
Context-Aware Smoothing for Neural Machine Translation

In Neural Machine Translation (NMT), each word is represented as a low-dimension, real-value vector for encoding its syntax and semantic information. This means that even if the word is in a different sentence context, it is represented as the fixed vector to learn source representation. Moreover, a large number of Out-Of-Vocabulary (OOV) words, which have different syntax and semantic information, are represented as the same vector representation of “unk”. To alleviate this problem, we propose a novel context-aware smoothing method to dynamically learn a sentence-specific vector for each word (including OOV words) depending on its local context words in a sentence. The learned context-aware representation is integrated into the NMT to improve the translation performance. Empirical results on NIST Chinese-to-English translation task show that the proposed approach achieves 1.78 BLEU improvements on average over a strong attentional NMT, and outperforms some existing systems.
EFFECTS OF FEEDING COLOSTRUM AND MILK OF HOLSTEIN COWS ON GROWTH RATE , IMMUNOGLOBULIN LEVELS AND METABOLIC TRAITS IN JERSEY CALVES PRODUCED BY EMBRYO TRANSFER : COMPARISON WITH HOLSTEIN CALVES

The aim of the present study was to assess the effects of Holstein dam’s colostrum and milk on growth rate, immunoglobulin levels, and metabolic traits in Jersey calves produced by embryo transfer: comparison with Holstein calves. All calves received colostrum within half an hour after birth at the rate of 2.4-3.9 L were 10% BW basis, and continued for the first 3 days and milk from after that to weaning at 8 weeks; they were fed twice daily in equal amounts more or less 5-10% of their BW. Also, calves were provided water ad libitum, grass hay, and calf starter at 7 days after birth. Results exhibited the content and immunoglobulin levels of colostrum gradually decreased with increasing age after birth. Jersey calves had lower BW (P<0.05) at preweaning period and mean ADG over 56 days compared with Holstein calves (P>0.05). However, feed efficiency was higher in Jersey than in Holstein calves (P>0.05). The level of plasma IgG was over 10 mg/mL, which indicated the successful transfer of passive immunity in Jersey and Holstein calves. Indeed, feeding the milk of Holstein dams did not significantly affect plasma total protein, glucose, urea nitrogen, and NEFA concentrations of Jersey calves as compared with Holstein calves. Therefore, these data suggest that feeding Holstein dam’s milk will not affect the growth performance, immunoglobulin level and metabolic traits of Jersey calves produced by embryo transfer.
A randomized controlled trial on the long‐term effects of proprioceptive neuromuscular facilitation training, on pain‐related outcomes and back muscle activity, in patients with chronic low back pain

BACKGROUND The role of exercise therapy in improving pain-related clinical outcomes and trunk muscle activity in patients with chronic low back pain (CLBP) has been widely reported. There is little information on the effect of proprioceptive neuromuscular facilitation (PNF) training in patients with CLBP. The purpose of the present study was therefore to investigate the persistence of the effects of PNF training on pain intensity, functional disability, patient satisfaction, health-related quality of life (HRQOL) and lower back muscle activity in patients with CLBP. METHODS Forty-two participants with CLBP were randomly assigned either to 4-week PNF training or to a control group receiving a Low back pain educational booklet. Pain-related outcomes, including pain intensity, functional disability, patient satisfaction, HRQOL and lumbar erector spinae (LES) muscle activity, were measured before and after the intervention, and at a follow-up session 12 weeks after the last intervention session. RESULTS Compared with the control group, after undergoing a 4-week PNF training intervention, participants showed a significant reduction in pain intensity and functional disability, and improved patient satisfaction and HRQOL (p < 0.01). These effects were still significant at the 12-week follow-up assessment (p < 0.01). LES muscle activity in the PNF training group was significantly increased throughout the measurement periods compared with controls (p < 0.01). CONCLUSIONS The study found that 4-week PNF training has positive long-term effects on pain-related outcomes, and increases lower back muscle activity in patients with CLBP.
Influence of Non-Ideal Factors on the Boundary Control of Buck Converters With Curved Switching Surfaces

In boundary control for Buck converters, the dynamic behavior characteristics are strongly influenced by some non-ideal factors. This influence is detailedly analyzed in this paper, and some design principles of the switching surface (SS) are proposed accordingly. First, by using the Adomian decomposition method, a general expression which can approximate the theoretically time-optimal SS with different degrees is obtained, and it can be seen as an extension of the existing second-order SSs. Second, the influences of load resistance, the ratio of capacitance and inductance, parasitic parameters, and the truncation order of SS are respectively shown by analyzing the behavior characteristics of the points along the SSs. For a specific SS, it is shown that the light load and low ratio of capacitance and inductance may cause overshoot of output voltage, which should be avoided in practical application. The simulation and experimental results are provided to confirm the correctness of theoretical analyses, which can give some instructions to determine the SS coefficients in the application of boundary control.
Electrophysiological approaches to noise sensitivity

ABSTRACT Background: Noise sensitivity describes an individual’s general reactivity to sound. It is a common trait found in many clinical populations and describes approximately 20% of the general population. Little is known about its underlying mechanisms, however. Objectives: Here we present findings from three studies designed to expose differences in electrophysiological measures between noise-sensitive and noise-resistant individuals. Method: Noise sensitivity was estimated using self-report measures, while electrophysiological indices included both cardiac (heart rate, heart rate variability) and electroencephalographic (event-related potential) measures. All three studies were designed with reference to preexisting theoretical frameworks. Results: Significant differences in heart rate change and heart rate variability indices between noise-sensitive and noise-resistant groups were found. Further, the noise-sensitive group exhibited less sensory gating than the noise-resistant group. Conclusions: While the findings from all three studies were not definitive in indicating a likely biological mechanism underlying noise sensitivity, they do suggest that electrophysiological investigation of noise sensitivity is viable and has potential to inform clinical research into a relatively understudied symptom.
Strongly Photoluminescent CdTe Nanocrystals by Proper Surface Modification

CdTe nanoclusters were prepared in aqueous solution by the reaction between Cd2+ and NaHTe in the presence of thioglycolic acid. Under reflux, the clusters start to crystallize and show a narrow band emission. The photoluminescence efficiency of CdTe nanocrystals strongly depends on the pH value of the colloidal solution. The maximum quantum yield at room temperature is approximately 18% when the pH value of the CdTe solution is brought to 4.5 by using thioglycolic acid. The optical spectroscopy studies imply that the pH-dependent behavior of the CdTe nanocrystals' fluorescence is caused by structural changes on the surface rather than the size of the nanocrystals. Systematic absorption and fluorescence studies on dialyzed samples suggest that in the acidic range a shell of cadmium thiol complexes is formed around the CdTe core. Thus, the fluorescence quantum yield is enhanced dramatically when the solution is made acidic. In contrast, such a shell can also be produced in the alkaline range, but only afte.
Janus kinase 2 and signal transducer and activator of transcription 3 activation is not essential for CCL3‐, CCL5‐ or CCL8‐induced chemotaxis

Chemokine receptors induce cell migration, but the molecular basis of the signal cascade involved is not completely understood. Therefore, we investigated here the molecular mechanisms of CCL3‐, CCL5‐ and CCL8‐induced cells migration and investigated whether the Janus kinase/signal transducer and activator of transcription (STAT) signalling pathway is involved. Some STAT3 inhibitors, like Cucurbitacin I, destroy the actin cytoskeleton inside the cells and therefore prevent any cellular migration. However, for inhibitors that do not affect the actin cytoskeleton or induce cell death, we show that chemokine‐induced cell migration is not dependent on activation of Janus kinase 2 or STAT3. Copyright © 2012 John Wiley & Sons, Ltd.
Atomic layer deposition of TiN layer on TiO2 nanotubes for enhanced supercapacitor performance

In this paper, vertical ordered TiO2 nanotubes (TNT) with highly conductive titanium nitride (TiN) are sequentially fabricated by electrochemical anodization on Ti foils and atomic layer deposition (ALD) technique. The hollow structure of TNT and highly conductive TiN allow the electrolyte to permeate into TNT and prompt faster charge transfer. Thus, the TNT-TiN composite electrode yields the maximum specific capacitance of 10.01 mF/cm2 at a scanning rate of 1mV/s, which is 24.4 times higher than that of pristine TNT. Importantly, TNT-TiN also present outstanding cycling stability with 91.9% retention of original specific capacitance after 2000 cycles. These excellent performances showed TNT-TiN electrodes could be regarded as promising material for electrical double-layer capacitor (EDLC) or as a good scaffold material for pseudocapacitors, which should be pave a new avenue for energy storage devices.
Burkholderia mallei CLH001 Attenuated Vaccine Strain Is Immunogenic and Protects against Acute Respiratory Glanders

ABSTRACT Burkholderia mallei is the causative agent of glanders, an incapacitating disease with high mortality rates in respiratory cases. Its endemicity and ineffective treatment options emphasize its public health threat and highlight the need for a vaccine. Live attenuated vaccines are considered the most viable vaccine strategy for Burkholderia, but single-gene-deletion mutants have not provided complete protection. In this study, we constructed the select-agent-excluded B. mallei ΔtonB Δhcp1 (CLH001) vaccine strain and investigated its ability to protect against acute respiratory glanders. Here we show that CLH001 is attenuated, safe, and effective at protecting against lethal B. mallei challenge. Intranasal administration of CLH001 to BALB/c and NOD SCID gamma (NSG) mice resulted in complete survival without detectable colonization or abnormal organ histopathology. Additionally, BALB/c mice intranasally immunized with CLH001 in a prime/boost regimen were fully protected against lethal challenge with the B. mallei lux (CSM001) wild-type strain.
Managing Titanium Mesh Exposure With Partial Removal of the Exposed Site: A Case Series Study.

ental implants have become a successful treatment modality for the totally 1 or partially 2 edentulous patient. Bone augmentation techniques have been introduced for clinical situations in which there is inadequate bone volume to successfully place dental implants. 3–5 Titanium mesh (TiMe) is a device for guided bone regeneration that has been used with the most desirable outcome in osseous wound space maintenance. 5,6 TiMe has been used successfully in alveolar ridge augmentation, 7–11 sinus augmentation, 12 treatment of cleft palate, 10,13 and in situations with simultaneous placement of dental implants. 14,15 Several authors have used the TiMe in conjunction with a variety of graft materials
Joint Estimation of Multiple Conditional Gaussian Graphical Models

In this paper, we propose a joint conditional graphical Lasso to learn multiple conditional Gaussian graphical models, also known as Gaussian conditional random fields, with some similar structures. Our model builds on the maximum likelihood method with the convex sparse group Lasso penalty. Moreover, our model is able to model multiple multivariate linear regressions with unknown noise covariances via a convex formulation. In addition, we develop an efficient approximated Newton’s method for optimizing our model. Theoretically, we establish the asymptotic properties of our model on consistency and sparsistency under the high-dimensional settings. Finally, extensive numerical results on simulations and real data sets demonstrate that our method outperforms the compared methods on structure recovery and structured output prediction. To the best of our knowledge, the joint learning of multiple multivariate regressions with unknown covariance is first studied.