Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic expression profile of olfactory ensheathing cells is distinct from that of Schwann cells and astrocytes

Olfactory ensheathing cells (OECs) accompany the axons of olfactory receptor neurons, which regenerate throughout life, from the olfactory mucosa into the olfactory bulb. OECs have shown widely varying efficacy in repairing the injured nervous system. Analysis of the transcriptome of OECs will help in understanding their biology and will provide tools for investigating the mechanisms of their efficacy and interactions with host tissues in lesion models. In this study, we compared the transcriptional profile of cultured OECs with that of Schwann cells (SCs) and astrocytes (ACs), two glial cell types to which OECs have similarities. Two biological replicates of RNA from cultured OECs, SCs, and ACs were hybridized to long oligo rat 5K arrays against a common reference pool of RNA (50% cultured fibroblast RNA and 50% neonatal rat brain RNA). Transcriptional profiles were analyzed by hierarchical clustering, Principal Components Analysis, and the Venn diagram. The three glial cell types had similarly increased or decreased expression of numerous transcripts compared with the reference. However, OECs were distinguishable from both SCs and ACs by a modest number of transcripts, which were significantly enriched or depleted. Furthermore, OECs and SCs were more closely related to each other than to ACs. Expression of selected transcripts not previously characterized in OECs, such as Lyz, Timp2, Gro1 (Cxcl1), Ccl2 (MCP1), Ctgf, and Cebpb, was validated by real‐time reverse transcription‐polymerase chain reaction (RT‐PCR); immunohistochemistry in cultured OECs, SCs, and ACs, and adult tissues was performed to demonstrate their expression at the protein level. © 2005 Wiley‐Liss, Inc.
The Stubbed Great Toe: Importance of Early Recognition and Treatment of Open Fractures of the Distal Phalanx

Stubbing injuries to the great toe can be a cause of occult open fractures and osteomyelitis. Five such patients were identified after conducting a retrospective review of injuries to the hallux between January 1998 and December 1998. The study was conducted to draw attention to the association between this trivial trauma and its possible complications. All five children had open fractures of the distal phalanx of the great toe. Osteomyelitis did not develop in the children whose injuries were recognized early and who were treated with antibiotics. However, three children with delayed diagnoses and treatment developed osteomyelitis. At a mean follow-up of 10 months (range, 9–11) after injury, all five fractures had healed with no active signs of infection. Two of these children experienced a partial growth arrest and two experienced a full growth arrest of the distal phalanx of the great toe, the significance of which is yet unknown. Clinical signs such as bleeding from the eponychium and a laceration proximal to the nail bed should alert physicians to the presence of a possible open fracture. Early detection and treatment of these injuries may reduce or eliminate hospital stays and prolonged intravenous antibiotic treatment for osteomyelitis.
Labour Market Responsiveness of Greek Apprenticeships: An Empirical Investigation

The ongoing economic crisis in Greece has given rise to a new interest in apprenticeships, linked to the perception that such programmes can provide an alternative to an academic educational pathway that can boost the employment prospects of young people. Against this background and drawing on the findings of a large-scale, mostly qualitative, research project that reviewed the Greek apprenticeship system and involved surveying 150 stakeholders, this original exploratory article provides a critical, succinct, but also comprehensive exploration of three major themes associated with a key aspect of apprenticeships in Greece: labour market responsiveness. These themes which emerged from the thematic content analysis undertaken, are: (i) content-related issues; (ii) actor-related issues; and (iii) issues related to the mismatch between the offer of and demand for apprenticeship positions. The article argues that, despite some strengths, serious weaknesses jeopardize the potential of apprenticeships in Greece to function as an effective alternative to academic study and an efficient path towards labour market integration.
Efficacy of a Jellyfish Sting Inhibitor in Preventing Jellyfish Stings in Normal Volunteers

Objective To evaluate the protective effects of a jellyfish sting inhibitor formulated in sunscreen lotion vs conventional sunscreen against Chrysaora fuscescens and Chiropsalmus quadrumanus jellyfish. Methods Twenty-four healthy subjects at 2 research sites were randomly assigned to receive the jellyfish sting inhibitor (Nidaria Technology Ltd, Jordan Valley, Israel) to one forearm and conventional sunscreen to the other arm in a blinded fashion. Subjects were stung with jellyfish tentacles on each forearm for up to 60 seconds. Erythema and pain were assessed at 15-minute intervals over a 2-hour period. Results In the C fuscescens group, all 12 arms pretreated with conventional sunscreen demonstrated erythema, and all subjects noted subjective discomfort. In contrast, no arm pretreated with the jellyfish sting inhibitor had objective skin changes (P < .01). Two subjects noted minimal discomfort in the arm treated with the sting inhibitor (P < .01). In the C quadrumanus group, discomfort was reported in 3 of the 12 inhibitor-treated arms compared with 10 of the 12 placebo-treated arms (P < .05). Erythema was noted on 1 arm treated with the inhibitor and 9 arms treated with the placebo (P < .01). Conclusions The jellyfish sting inhibitor prevented sting symptoms of C fuscescens jellyfish in 10 of 12 subjects and diminished the pain of the jellyfish sting in the remaining 2 subjects. The jellyfish sting inhibitor also inhibited the more severe sting of the C quadrumanus jellyfish in the majority of subjects. The jellyfish sting inhibitor does not eliminate the sting from C fuscescens or C quadrumanus jellyfish but significantly reduces the frequency and severity of stings.
Validity of Research-Grade Actigraphy Unit for Measuring Exercise Intensity

This study was conducted in a free-living setting to investigate the measurement validity of a research-based actigraph for strolling and jogging, and to provide a reference for actual practice and research. Because inadequate physical activity (PA) or sedentary lifestyle has become the fourth leading risk factor for mortality worldwide, many countries have been vigorously promoting the concept of “active living”, and the public has been investing greater effort into intensifying their PA. Although research-grade actigraphs have been widely applied to evaluate PA in routine environments, the measurement results may not accurately reflect the wearers’ PA. Unlike most relevant research, which is conducted in well-controlled laboratory environments, the present study was implemented in the field to examine the sensitivity and convergent validity of the MicroMini Motionlogger® Actigraph during strolling and jogging. The following results were revealed: (1) Although the exercise movement speed while jogging was significantly faster than that while strolling, the actigraph readings showed no significant difference between strolling and jogging; (2) The actigraph readings were (significantly or nonsignificantly) negatively correlated with metabolic heat and nonsignificantly correlated with movement speeds. Hence, the actigraph validity for measuring PA intensity while strolling and jogging remains debatable.
Is mucosal healing more common than clinical remission in ulcerative colitis? – Is it the truth or only a myth coming from the studies?

Abstract Background. The most important goals of the recent therapies of ulcerative colitis (UC) are to induce and maintain clinical remission and to achieve mucosal healing (MH). Rate of endoscopic remission has been shown to be higher than that of clinical remission in large trials like ULTRA and PURSUIT. The aim of our study was to evaluate the correlation between clinical and endoscopic disease activities of UC defined by activity scores. Methods. Clinical and endoscopic activities were evaluated in 100 consecutive UC patients. Clinical activities were defined by two activity indices: the Rachmilewitz Activity Index (CAI) and the partial Mayo score. Colonoscopies and patient enrollments were performed by two experienced gastroenterologists and endoscopists. They graded the findings both according to the endoscopic part of the Rachmilewitz Endoscopic Activity Index (EI) and the Mayo endoscopic subscore. MH was defined as Mayo endoscopic subscore and EI of 0. Histological activity was scored by Riley score. Results. Clinical and endoscopic activities showed strong correlations using both scoring systems (p = 0.0029 and p = 0.0001). Endoscopic disease activity also correlated with the histological activity (p ≥ 0.001). Significant correlation was shown between the clinical activity and MH (p = 0.0012 and p ≥ 0.001). No association was showed with the extension of the disease and clinical or endoscopic activity. Conclusion. Assessment of MH is very important for guiding therapy and for evaluation of remission in patients with UC. Our result showed good correlation between the clinical, endoscopic, and histological activities of UC focusing on the importance of evaluating the endoscopic activity of the patients.
Second-Life Batteries on a Gas Turbine Power Plant to Provide Area Regulation Services

Batteries are used in the electricity grid to provide ancillary services. Area regulation seems to provide substantial revenues and profit, but Li-ion batteries are still too expensive to enter widely into this market. On the other hand, electric vehicle (EV) batteries are considered inappropriate for traction purposes when they reach a state of health (SoH) of 80%. The reuse of these batteries offers affordable batteries for second-life stationary applications. This study analyzes two possible scenarios where batteries may give power and energy support to a gas turbine cogeneration power plant, and how long these batteries may last under different loads.
Magnetic, structural and magnetocaloric properties of Ni-Si and Ni-Al thermoseeds for self-controlled hyperthermia

Abstract Self-controlled hyperthermia is a non-invasive technique used to kill or destroy cancer cells while preserving normal surrounding tissues. We have explored bulk magnetic Ni-Si and Ni-Al alloys as a potential thermoseeds. The structural, magnetic and magnetocaloric properties of the samples were investigated, including saturation magnetisation, Curie temperature (TC), and magnetic and thermal hysteresis, using room temperature X-ray diffraction and magnetometry. The annealing time, temperature and the effects of homogenising the thermoseeds were studied to determine the functional hyperthermia applications. The bulk Ni-Si and Ni-Al binary alloys have Curie temperatures in the desired range, 316 K–319 K (43 °C–46 °C), which is suitable for magnetic hyperthermia applications. We have found that TC strictly follows a linear trend with doping concentration over a wide range of temperature. The magnetic ordering temperature and the magnetic properties can be controlled through substitution in these binary alloys.
Observations on experimental marginal periodontitis in rats.

OBJECTIVE The purpose of this study was to assess periodontal destruction following experimentally induced marginal periodontitis in rats by ligatures over a 60-day observation period. The extent to which the physiological movement of teeth influenced the effect of the ligatures was also examined. In addition, two methods for measuring bone loss in the defleshed jaw were compared. METHODS Thirty-five male Sprague-Dawley rats (SD) were divided into five groups. Marginal periodontitis was induced by ligatures on the second maxillary molars. Rats were killed after 15, 30, and 60 days. Rats in the control group were killed on day 1 and day 60. Bone loss was determined with two different methods on the buccal and palatinal surfaces of the defleshed jaw. In the first method, the distance of the cementoenamel junction (CEJ) from the alveolar bone crest (ABC) was measured at different sites; in the second method, the area of the exposed root surface of the molars was measured. RESULTS Comparison of the control groups from day 1 and day 60 using both measuring methods showed significant differences in bone loss. In the area where the ligature was located, test rats exhibited significantly greater bone loss than control rats. Comparison of control rats from day 1 with test rats from day 15 showed that the increase in bone loss between the groups within the area of the ligature was significantly greater than outside it. The age-dependent bone loss increases over the entire observation period of 60 days. The ligature-induced bone loss increased most from day 1 to day 15; on days 30 and 60, slighter increases in bone loss were observed. CONCLUSIONS The application of this model can only be recommended for short (</=15 days) observation periods. The distance method should be preferred to the area method.
Curriculum for the Hospitalized Aging Medical Patient Review

Geriatricians, hospitalists, general medicine faculty, and PhD educators at the University of Chicago Pritzker School of Medicine designed the Curriculum for the Hospitalized Aging Medical Patient (CHAMP) with support from the Donald W. Reynolds Foundation. It represents a comprehensive faculty development curriculum in hospital‐based geriatrics. The program comprises multiple educational modules including PowerPoint presentations, bedside teaching triggers, and workshops for faculty learners. The curriculum includes evaluation instruments, observed structured teaching exercises, and pocket teaching cards with pearls for ward‐based teaching.
SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome

Summary Sorting nexins (SNXs) are key regulators of the endosomal network. In designing an RNAi-mediated loss-of-function screen, we establish that of 30 human SNXs only SNX3, SNX5, SNX9, SNX15 and SNX21 appear to regulate EGF receptor degradative sorting. Suppression of SNX15 results in a delay in receptor degradation arising from a defect in movement of newly internalised EGF-receptor-labelled vesicles into early endosomes. Besides a phosphatidylinositol 3-phosphate- and PX-domain-dependent association to early endosomes, SNX15 also associates with clathrin-coated pits and clathrin-coated vesicles by direct binding to clathrin through a non-canonical clathrin-binding box. From live-cell imaging, it was identified that the activated EGF receptor enters distinct sub-populations of SNX15- and APPL1-labelled peripheral endocytic vesicles, which do not undergo heterotypic fusion. The SNX15-decorated receptor-containing sub-population does, however, undergo direct fusion with the Rab5-labelled early endosome. Our data are consistent with a model in which the EGF receptor enters the early endosome following clathrin-mediated endocytosis through at least two parallel pathways: maturation through an APPL1-intermediate compartment and an alternative more direct fusion between SNX15-decorated endocytic vesicles and the Rab5-positive early endosome.
Return and Volatility Spillover across Equity Markets Between China and Southeast Asian Countries

Purpose This paper aims to study the daily returns and volatility spillover effects in common stock prices between China and four countries in Southeast Asia (Vietnam, Thailand, Singapore and Malaysia). Design/methodology/approach The analysis uses a vector autoregression with a bivariate GARCH-BEKK model to capture return linkage and volatility transmission spanning the period including the pre- and post-2008 Global Financial Crisis. Findings The main empirical result is that the volatility of the Chinese market has had a significant impact on the other markets in the data sample. For the stock return, linkage between China and other markets seems to be remarkable during and after the Global Financial Crisis. Notably, the findings also indicate that the stock markets are more substantially integrated into the crisis. Practical implications The results have considerable implications for portfolio managers and institutional investors in the evaluation of investment and asset allocation decisions. The market participants should pay more attention to assess the worth of across linkages among the markets and their volatility transmissions. Additionally, international portfolio managers and hedgers may be better able to understand how the volatility linkage between stock markets interrelated overtime; this situation might provide them benefit in forecasting the behavior of this market by capturing the other market information. Originality/value This paper would complement the emerging body of existing literature by examining how China stock market impacts on their neighboring countries including Vietnam, Thailand, Singapore and Malaysia. Furthermore, this is the first investigation capturing return linkage and volatility spill over between China market and the four Southeast Asian markets by using bivariate VAR-GARCH-BEKK model. The authors believe that the results of this research’s empirical analysis would amplify the systematic understanding of spillover activities between China stock market and other stock markets.
Dual frequency microstrip patch antenna for GPS and WiMAX application

This paper presents the design of a microstrip patch antenna (MPA) for dual-frequency operation at 2.1 GHz and 5.8 GHz for Global Positioning System (GPS) and WiMAX applications respectively. The size of the antenna is 65 mm × 88 mm and simulated using Computer Simulation Technology (CST) software. Upon achieving an optimum performance, the antenna was implemented on a FR4 substrate with dielectric constant, εr = 5, loss tangent, tanδ = 0.02 and thickness, h=1.6 mm and tested using the Vector Network Analyzer (VNA). Both the simulation and experimental results were then compared and analysed. It was found that the antenna operates well near the designed frequencies of operations. Good agreements have been achieved for both the simulation and experimental results
Final kissing balloon inflation by classic crush stenting did not improve the clinical outcomes for the treatment of unprotected left main bifurcation lesions: The importance of double‐kissing crush technique

The mechanisms contributing to final kissing balloon inflation between classic crush and double‐kissing (DK) crush stenting techniques for the treatment of coronary bifurcation lesions contrast. The authors compared the clinical outcomes in patients with unprotected distal left main bifurcation lesions treated by classic crush or DK crush stenting techniques.
Effect of high‐frequency bio‐oxidative ozone therapy for masticatory muscle pain: a double‐blind randomised clinical trial

To evaluate the effect of bio-oxidative ozone application at the points of greatest pain in patients with chronic masticatory muscle pain. A total number of 40 (40 women, with a mean age of 31·7) were selected after the diagnosis of myofacial pain dysfunction syndrome according to the Research Diagnostic Criteria for temporomandibular disorder (RDC/TMD). The patients were randomly divided into two groups: patients received the ozone therapy at the point of greatest pain, ozone group (OG; n = 20); patients received the sham ozone therapy at the point of greatest pain, placebo group (PG; n = 20). Ozone and placebo were applied three times per week, for a total of six sessions. Mandibular movements were examined, masticator muscles tenderness were assessed and pressure pain threshold (PPT) values were obtained. Subjective pain levels were evaluated using visual analogue sale (VAS). These assessments were performed at baseline, 1 month and 3 months. Ozono therapy decreased pain intensity and increased PPT values significantly from baseline to 1 month and 3 months in OG compared with PG. PPTs of the temporal (OG = 24·85 ± 6·65, PG = 20·65 ± 5·43, P = 0.035) and masseter (OG = 19·03 ± 6·42, PG = 14·23 ± 2·95, P = 0.007) muscles at 3 months of control (T2) were significantly higher in the OG group. PPT value of the lateral pole was also significantly higher at T2 in the OG group (OG = 21·25 ± 8·43, PG = 15·35 ± 4·18, P = 0.012). Mandibular movements did not show significant differences between treatment groups except right lateral excursion values at T2 (OG = 8·90 ± 1·77, PG = 6·85 ± 2·41, P = 0.003); however, OG demonstrated significantly better results over time. Overall improvements in VAS scores from baseline to 3 months were OG 67·7%; PG 48·4%. Although ozone therapy can be accepted as an alternative treatment modality in the management of masticatory muscle pain, sham ozone therapy (placebo) showed significant improvements in the tested parameters.
Ferromagnetic insulating and spin glass behavior in Cr substituted La0.85Ag0.15MnO3 compounds

Single phase samples of polycrystalline La0.85Ag0.15Mn1−yCryO3 (y = 0, 0.05, 0.10, 0.15, 0.20) were prepared by the solid-state route. These samples were studied by recording x-ray diffraction patterns to investigate their crystal structure, by measuring temperature and frequency variations of ac susceptibility and high temperature magnetization to investigate their magnetic properties and by measuring magneto-resistivity. X-ray diffraction patterns could be refined by using the space group. The lattice parameters and Mn–O bond lengths were found to decrease with Cr doping. Paramagnetic to ferromagnetic transitions followed by low temperature spin glass like behavior have been observed from ac susceptibility results. The above transitions could be understood on the basis of double exchange ferromagnetic interaction in Mn3+–O2−–Mn4+, super-exchange ferromagnetic interaction in Cr3+–O2−–Mn3+ and super-exchange antiferromagnetic interaction in Mn4+–O2−–Mn4+ networks. Even though a strong ferromagnetic signal was observed in all the Cr doped samples, no metal–insulator transition has been observed. Thus Cr doping gives rise to a ferromagnetic insulating state and the Cr might take part in super-exchange ferromagnetic interactions. Colossal magneto-resistivity has been observed up to 20% of Cr doping in a wide temperature range down to low temperatures.
Survival of primordial follicles following prolonged transportation of ovarian tissue prior to cryopreservation.

BACKGROUND Cryopreservation of ovarian tissue for fertility preservation is becoming increasingly common. Treatment of diseases that may deprive the ovaries of follicles is often performed at local hospitals that are without the necessary facilities and expertise to cryopreserve ovarian tissue. The aim of the present study was to evaluate whether primordial follicles of ovarian cortex survive transport for up to 4 h prior to cryopreservation. METHODS Immediately after recovery of one ovary from each of four patients, the cortex was roughly isolated, placed in IVF culture medium, kept on ice and transported for 3-4 h to the centre where final dissection and cryopreservation took place. Transplantation of pieces of thawed ovarian cortex under the skin of ovariectomized immunodeficient mice for a period of 4 weeks was used to assess the survival of primordial follicles. RESULTS After transplantation, ovarian tissue from each of the four patients contained surviving follicles. CONCLUSIONS Transport of roughly isolated ovarian cortex cooled on ice for a period of up to 4 h allows survival of primordial follicles following cryopreservation and transplantation to immunodeficient mice.