Miracle-dz/UniFAR-FTUs huggingface dataset:
Charge-based femto-farad capacitance measurement technique for MEMS applications

This paper presents design and simulation of CMOS circuits intended for on-chip differential-mode charge based capacitance measurements in the femto-farad range. The circuits can be integrated with MEMS sensors in CMOS-compatible technology. The reported circuits are characterized by very high sensitivity and a linear C-V response. The performance of differential CBCM circuits using simple current mirrors and novel current-voltage mirrors has also been covered.
Spatiotemporal Expression Patterns of Metalloproteinases and Their Inhibitors in the Postnatal Developing Rat Cerebellum

Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade the components of the extracellular matrix (ECM). The balance between MMPs and their inhibitors [tissue inhibitors of metalloproteinases (TIMPs)] in the pericellular environment determines the most significant proteolytic events in tissue remodeling. In vitro evidence is accumulating that these molecules may be crucial in the maturation of neural cells. Here, we investigated thein vivo expression of MMPs 2, 3, and 9 and TIMPs 1, 2, and 3 in the developing and adult rat cerebellum using immunohistochemistry and in situ hybridization. During postnatal development, all Purkinje (PK) cell somata expressed all the MMPs and TIMPs studied, whereas their growing dendritic trees expressed only MMP 3 and TIMP 3. In the adult, MMP 3 was confined to PK cell bodies, whereas TIMP 3 was expressed in PK cell somata and processes. Irrespective of the developmental stage, Bergmann glial processes contained only MMP 9, but their somata contained both TIMP 1 and MMP 9. In granular cells, MMPs 3 and 9 and TIMPs 1, 2, and 3 were chiefly detected at a time when migration is known to be maximal; except for that of TIMP 1, their expression persisted in the internal granular layer in the adult. The functional relevance of MMP expression was verified by gelatin zymography. MMP 9 activity was maximal on postnatal day 10 (P10) and was detectable at a low level on P15 and in the adult, whereas MMP 2 activity remained similar throughout postnatal development. Regional and cell-specific expression of MMPs and TIMPs closely reflects the successive stages of cerebellar development, thereby suggesting a pivotal role for ECM proteolysis in brain development and plasticity.
Templates to derive security metric based on attack patterns

Attack pattern system exhibits a unique property of pattern sequential cascading nature applied during the design phase of an application system. In this paper a mathematical framework based on predicate and propositional logic is applied to verify and check the mentioned property with the help of design specification. The framework also defines few predicate operators to construct the results in terms of propositions that each pattern displays during the design in the context of security scenario. Finally the results are presented against number of patterns along with number of propositions, operators, other resources where pattern consumes during the implementation scenario. Templates are proposed to present the pattern data to derive the desired security metric.
Development of a UAV-LiDAR System with Application to Forest Inventory

We present the development of a low-cost Unmanned Aerial Vehicle-Light Detecting and Ranging (UAV-LiDAR) system and an accompanying workflow to produce 3D point clouds. UAV systems provide an unrivalled combination of high temporal and spatial resolution datasets. The TerraLuma UAV-LiDAR system has been developed to take advantage of these properties and in doing so overcome some of the current limitations of the use of this technology within the forestry industry. A modified processing workflow including a novel trajectory determination algorithm fusing observations from a GPS receiver, an Inertial Measurement Unit (IMU) and a High Definition (HD) video camera is presented. The advantages of this workflow are demonstrated using a rigorous assessment of the spatial accuracy of the final point clouds. It is shown that due to the inclusion of video the horizontal accuracy of the final point cloud improves from 0.61 m to 0.34 m (RMS error assessed against ground control). The effect of the very high density point clouds (up to 62 points per m2) produced by the UAV-LiDAR system on the measurement of tree location, height and crown width are also assessed by performing repeat surveys over individual isolated trees. The standard deviation of tree height is shown to reduce from 0.26 m, when using data with a density of 8 points perm2, to 0.15mwhen the higher density data was used. Improvements in the uncertainty of the measurement of tree location, 0.80 m to 0.53 m, and crown width, 0.69 m to 0.61 m are also shown.
Role of oxygen in phagocyte microbicidal action.

Immune information in the form of inflammatory mediators directs phagocyte locomotion and increases expression of opsonin receptors such that contact with an opsonized microbe results in receptor ligation and activation of microbicidal metabolism. Carbohydrate dehydrogenation and O2 consumption feed reactions that effectively lower the spin quantum number (S) of O2 from 1 to 1/2 and finally to 0. Oxidase-catalyzed univalent reduction of O2 (S = 1; triplet multiplicity) yields hydrodioxylic acid (HO2) and its conjugate base superoxide, O2- (S = 1/2; doublet multiplicity). Acid or enzymatic disproportionation of superoxide yields H2O2 (S = 0; singlet multiplicity). Haloperoxidase catalyzes H2O2-dependent oxidation of Cl- yielding HOCl (S = 0), and reaction of HOCl with H2O2 yields singlet molecular oxygen, 1O2 (S = 0; singlet multiplicity). The Wigner spin conservation rule restricts direct reaction of S = 1 O2 with S = 0 organic molecules. Lowering the S of O2 overcomes this spin restriction and allows microbicidal combustion. High exergonicity dioxygenation reactions yield electronically excited carbonyl products that relax by photon emission, i.e., phagocyte luminescence. Addition of high quantum yield substrates susceptible to spin allowed dioxygenation, i.e., chemiluminigenic substrates, greatly increases detection sensitivity and defines the nature of the oxygenating agent. Measurement of luminescence allows high sensitivity, real-time, and substrate-specific differential analysis of phagocyte dioxygenating activities. Under assay conditions where immune mediator and opsonin exposure are controlled, luminescence analysis of the initial phase of opsonin-stimulated oxygenation activity allows functional assessment of the opsonin receptor expression per circulating phagocyte and can be used to gauge the in vivo state of immune activation.
Exploring motion VEPs for gaze-independent communication

Motion visually evoked potentials (mVEPs) have recently been explored as input features for brain–computer interfaces, in particular for the implementation of visual spellers. Due to low contrast and luminance requirements, motion-based intensification is less discomforting to the user than conventional approaches. So far, mVEP spellers were operated in the overt attention mode, wherein eye movements were allowed. However, the dependence on eye movements limits clinical applicability. Hence, the purpose of this study was to evaluate the suitability of mVEPs for gaze-independent communication. Sixteen healthy volunteers participated in an online study. We used a conventional speller layout wherein the possible selections are presented at different spatial locations both in the overt attention mode (fixation of the target) and the covert attention mode (central fixation). Additionally, we tested an alternative speller layout wherein all stimuli are sequentially presented at the same spatial location (foveal stimulation), i.e. eye movements are not required for selection. As can be expected, classification performance breaks down when switching from the overt to the covert operation. Despite reduced performance in the covert setting, conventional mVEP spellers are still potentially useful for users with severely impaired eye movements. In particular, they may offer advantages—such as less visual fatigue—over spellers using flashing stimuli. Importantly, the novel mVEP speller presented here recovers good performance in a gaze-independent setting by resorting to the foveal stimulation.
Multivariate backhaul compression for the downlink of cloud radio access networks

In the downlink of cloud radio access networks, a central encoder is connected to multiple multi-antenna base stations (BSs) via finite-capacity backhaul links. At the central encoder, precoding is followed by compression in order to produce the rate-limited bit streams delivered to each BS over the corresponding backhaul link. In current state-of-the-art schemes, the signals intended for different BSs are compressed independently. In contrast, this work proposes to leverage joint compression, also referred to as multivariate compression, of the signals for different BSs in order to better control the effect of the additive quantization noises at the mobile stations (MSs). The problem of maximizing the weighted sum-rate over precoding and compression strategies is formulated subject to power and backhaul capacity constraints. An iterative algorithm is proposed that achieves a stationary point of the problem. From numerical results, it is confirmed that the proposed joint precoding and compression strategy outperforms conventional approaches based on independent compression across the BSs.
Behavioral Interface Contracts for Java ( Rice University CS TR 00-366 )

Programs should consist of off-the-shelf, interchangeable, black-box components that are produced by a network of independent software companies. These components should not only come with type signatures but also with contracts that describe other aspects of their behavior. One way to express contracts is to state preand postconditions for externally visible functions. These preand post-conditions should then be validated during evaluation or possibly even during compilation. If a function call fails to satisfy its contract, the run-time system should blame the faulty program component. Behavioral contracts in the form of assertions are well-understood in the world of procedural languages. Their addition to class and interface hierarchies in object-oriented programming languages, however, raises many new and interesting questions. The most complicating factor is that objects can pass between components and trigger callbacks. Another problem is that object-oriented languages allow objects to satisfy several interfaces at once. In this paper, we analyze existing approaches to adding contracts to class-based languages and show how they blame the wrong component in certain situations for breach of contract. We then present a conservative extension of Java that allows programmers to specify method contracts in interfaces. The extension is a compromise between a consistent enforcement of contracts and language design concerns. In the future, we plan to clarify the relationship between contracts and contract violations with a rigorous analysis. 1 Contracts and Assertions Beugnard, Jézéquel, Plouzeau, and Watkins [1] suggest that software components should come with contracts. They describe four levels of contracts: 1. syntactic contracts (type systems), 2. behavorial contracts (invariants, preand post-conditions), 3. synchronization contracts, and 4. quality of service contracts. Type systems and other syntactic contracts for components have been studied extensively in object-oriented, functional, and higher-order contexts [2, 10, 16]. Behavioral contracts have been studied in procedural contexts [11, 19, 20, 25, 26]. Behavioral contracts have also been added to object-oriented languages [4, 9, 12, 13, 14, 21, 22, 24]. Adding behavioral contracts to object-oriented languages, however, is subtle. Each of the referenced systems fails
Effects of low-frequency repetitive transcranial magnetic stimulation of the contralesional primary motor cortex on movement kinematics and neural activity in subcortical stroke.

BACKGROUND Following the concept of interhemispheric competition, downregulation of the contralesional primary motor cortex (M1) may improve the dexterity of the affected hand after stroke. OBJECTIVE To determine the effects of 1-Hz repetitive transcranial magnetic stimulation (rTMS) of the contralesional M1 on movement kinematics and neural activation within the motor system in the subacute phase after subcortical stroke. DESIGN Crossover investigation. SETTING A university hospital. METHODS Fifteen right-handed patients with impaired dexterity due to subcortical middle cerebral artery stroke received 1-Hz rTMS for 10 minutes applied to the vertex (control stimulation) and contralesional M1. For behavioral testing, patients performed finger and grasp movements with both hands at 2 baseline conditions, separated by 1 week, and following each rTMS application. For functional magnetic resonance imaging, patients performed hand grip movements with their affected or unaffected hand before and after each rTMS application. RESULTS Application of rTMS to the contralesional M1 improved the kinematics of finger and grasp movements in the affected hand. At the neural level, rTMS applied to the contralesional M1 reduced overactivity in the contralesional primary and nonprimary motor areas. There was no significant correlation between the rTMS-induced reduction in blood oxygen level-dependent responses within the contralesional M1 and the degree of behavioral improvement of the affected hand. Overactivity of the contralesional dorsal premotor cortex, contralesional parietal operculum, and ipsilesional mesial frontal cortex at baseline predicted improvement of movement kinematics with the affected hand after rTMS of the contralesional M1. CONCLUSION The functional magnetic resonance imaging data suggest that rTMS of the contralesional M1 may normalize neural activation within the cortical motor network after subcortical stroke. Identifying patients suitable for rTMS intervention based on individual patterns of cortical activation may help to implement rTMS in motor rehabilitation after stroke.
Comprehensive Analysis of Bacterial Flora in Postoperative Maxillary Cyst Fluid by 16S rRNA Gene and Culture Methods

Intracystic fluid was aseptically collected from 11 patients with postoperative maxillary cyst (POMC), and DNA was extracted from the POMC fluid. Bacterial species were identified by sequencing after cloning of approximately 580 bp of the 16S rRNA gene. Identification of pathogenic bacteria was also performed by culture methods. The phylogenetic identity was determined by sequencing 517–596 bp in each of the 1139 16S rRNA gene clones. A total of 1114 clones were classified while the remaining 25 clones were unclassified. A total of 103 bacterial species belonging to 42 genera were identified in POMC fluid samples by 16S rRNA gene analysis. Species of Prevotella (91%), Neisseria (73%), Fusobacterium (73%), Porphyromonas (73%), and Propionibacterium (73%) were found to be highly prevalent in all patients. Streptococcus mitis (64%), Fusobacterium nucleatum (55%), Propionibacterium acnes (55%), Staphylococcus capitis (55%), and Streptococcus salivarius (55%) were detected in more than 6 of the 11 patients. The results obtained by the culture method were different from those obtained by 16S rRNA gene analysis, but both approaches may be necessary for the identification of pathogens, especially of bacteria that are difficult to detect by culture methods, and the development of rational treatments for patients with POMC.
More about arc-fault circuit interrupters

Since the arc-fault circuit interrupter (AFCI) was commercially introduced in 1998, questions have arisen about how it detects arcs, whether it detects series and parallel arcs, and what types of AFCIs are available. Types other than the original branch/feeder AFCI are emerging. This paper is intended to provide an update regarding answers to those questions, following an earlier paper that introduced the basic functioning of the AFCI.
Numerical simulation analyses of the collapse response of masonry structures under earthquake

Masonry structures are very easily collapsed in earthquakes, but there are few researches on the collapse response of masonry structures. Numerical simulation analysis is a main method that studies on the collapse response of masonry structures under earthquake. This method can replay the whole collapse process, and the cause of the collapse of the structure can be discussed and the measures against the similar collapse of structures can be proposed according to the calculation results. The numerical simulation analyses of the collapse response of masonry structures under earthquakes in china are briefly summarized. The collapse responses simulation of a two-story masonry structures under earthquakes by ANSYS/LS-DYNA is given, the results show that ground floor and wall between windows of masonry structures are the weak parts under earthquakes.
Neuroscience and Biobehavioral Reviews a Systematic Review of Fatigue in Patients with Traumatic Brain Injury: the Course, Predictors and Consequences

Background: Fatigue is common after traumatic brain injury (TBI). Its risk factors, natural history and consequences are uncertain. Best-evidence synthesis was used to address the gaps. Methods: Five databases were searched for relevant peer-reviewed studies. Of the 33 articles appraised, 22 longitudinal studies were selected. Results were reported separately based on their timing of baseline assessment. Results: All studies document changes in fatigue frequency and severity with time, irrespective of setting or TBI severity. There is limited evidence for certain clinical and psychosocial variables as predictors of fatigue severity at follow-up. Early fatigue severity predicted persistent post-concussive symptoms and Glasgow outcome score at follow-up. Conclusions: Fatigue is present before and immediately following injury, and can persist long term. The variation in findings supports the idea of fatigue in TBI as a nonhomogeneous entity, with different factors influencing the course of new onset or chronic fatigue. To decrease the heterogeneity, we emphasize the need for agreement on a core set of relevant fatigue predictors, definitions and outcome criteria. PROSPERO registry number: CRD42013004262.
Impact of PWM Schemes on Induction Motor Losses

This paper presents the results of an investigation into the impact of pulse width modulation (PWM) switching schemes on power losses in induction motors and their inverter drives. The PWM schemes considered include sinusoidal PWM, space-vector PWM and discontinuous PWM. Both experimental results and simulated predictions are presented for fractional horsepower and small integral horsepower motors. Direct loss measurements have been carried out using a calorimetric test rig; detailed simulations of the skewed motors have been carried out using multi-slice time-stepped 2D FEA. The simulated and measured losses under the different modulation schemes are compared and discussed
Differential cerebral response to somatosensory stimulation of an acupuncture point vs. two non-acupuncture points measured with EEG and fMRI

Acupuncture can be regarded as a complex somatosensory stimulation. Here, we evaluate whether the point locations chosen for a somatosensory stimulation with acupuncture needles differently change the brain activity in healthy volunteers. We used EEG, event-related fMRI, and resting-state functional connectivity fMRI to assess neural responses to standardized needle stimulation of the acupuncture point ST36 (lower leg) and two control point locations (CP1 same dermatome, CP2 different dermatome). Cerebral responses were expected to differ for stimulation in two different dermatomes (CP2 different from ST36 and CP1), or stimulation at the acupuncture point vs. the control points. For EEG, mu rhythm power increased for ST36 compared to CP1 or CP2, but not when comparing the two control points. The fMRI analysis found more pronounced insula and S2 (secondary somatosensory cortex) activation, as well as precuneus deactivation during ST36 stimulation. The S2 seed-based functional connectivity analysis revealed increased connectivity to right precuneus for both comparisons, ST36 vs. CP1 and ST36 vs. CP2, however in different regions. Our results suggest that stimulation at acupuncture points may modulate somatosensory and saliency processing regions more readily than stimulation at non-acupuncture point locations. Also, our findings suggest potential modulation of pain perception due to acupuncture stimulation.
A High-Throughput RNA Extraction for Sprouted Single-Seed Barley (Hordeum vulgare L.) Rich in Polysaccharides

Germinated seed from cereal crops including barley (Hordeum vulgare L.) is an important tissue to extract RNA and analyze expression levels of genes that control aspects of germination. These tissues are rich in polysaccharides and most methods for RNA extraction are not suitable to handle the excess polysaccharides. Here, we compare the current methods for RNA extraction applicable to germinated barley tissue. We found that although some of these standard methods produced high-quality RNA, the process of extraction was drastically slow, mostly because the frozen seed tissue powder from liquid N2 grinding became recalcitrant to buffer mixing. Our suggested modifications to the protocols removed the need for liquid N2 grinding and significantly increased the output efficiency of RNA extraction. Our modified protocol has applications in other cereal tissues rich in polysaccharides, including oat.
5-1-2008 Facilitating Issue Categorization & Analysis in Rulemaking

One task common to all notice-and-comment rulemaking is identifying substantive claims and arguments made in the comments by stakeholders and other members of the public. Extracting and summarizing this material may be helpful to internal decisionmaking; to produce the legally required public explanation of the final rule, it is essential. When comments are lengthy or numerous, natural language processing and machine learning techniques can help the rulewriter work more quickly and comprehensively. Even when a smaller volume of comment material is received, the ability to annotate relevant portions and store information about them in a way that permits retrieval and generation of reports can be useful to the agency, especially over time. We describe a prototype application for these purposes. The Workspace for Issue Categorization and Analysis (WICA) allows the rulewriter to create a list of relevant substantive categories and assign them to marked portions of comment text. She can then retrieve all instances of a given issue within the comment pool. Preliminary results of experiments that apply text categorization and active learning methods to comment sets suggest that these techniques can facilitate the marking and category assignment process in lengthy or numerous comment sets. WICA will incorporate these techniques. Other possible applications of WICA within the rulemaking process are discussed.