Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictors of Burnout for Psychiatric Occupational Therapy Personnel

Burnout is inherent in many health care professions. This research investigation was conducted to determine if burnout existed at significant levels and if a relationship between burnout, work environment factors and demographic characteristics existed among a group of psychiatric occupational therapy personnel. The study design was a descriptive survey format utilizing mailed questionnaires. Eighty-nine respondents completed the Maslach Burnout Inventory, the Work Environment Scale and a demographic questionnaire. A series of regression analyses were performed. The results indicated that the following were significant predictors of burnout: work involvement, a large percentage of clients on one's caseload diagnosed with schizophrenia, work pressure, age, income level, the length of time working in psychiatric occupational therapy, caseload size and the amount of overtime performed on a weekly basis. Implications for psychiatric occupational therapy practice are discussed and recommendations for future research are made.
WCDMA for UMTS: Radio Access for Third Generation Mobile Communications

From the Publisher: WCDMA for UMTS provides a complete picture of the Wideband CDMA (Code Division Multiple Access) air interface of the 3rd generation cellular systems - UMTS (Universal Mobile Telecommunications Systems). WCDMA is designed for multimedia communications including high quality images and video, and access to services with high data rates. These capabilities will create new business opportunities for manufacturers, operators and for the providers of content and applications. * Explains the key parts of the WCDMA standard and provides guidelines for its efficient use * Presents network dimensioning and coverage and capacity planning of WCDMA * Introduces radio resource management algorithms in the WCDMA network * Examines the coverage and capacity of WCDMA up to 2Mbps using numerous simulation results * Introduces the TDD (Time Divisions Duplex) mode * Discusses the co-existence of TDD and FDD (Frequency Divisions Duplex) and highlights their main differences Now includes the main modifications made to the 3GPP standard up until the end of 2000 and features the following new material: * Reference terminal classes * Current status of UMTS licensing * Capacity upgrade paths and capacity per km2 * Inter-frequency handovers and inter-system handovers to GSM * Antenna diversity gain measurements in the WCDMA experimental system Written by leading experts in the field, this practical approach to the key features in WCDMA will have wide-ranging appeal to Research and Development Engineers, Practising Engineers, Cellular Operators, Technical Managers and Students on Telecommunications courses.
Wavelets on graphs for very high resolution multispectral image texture segmentation

This paper proposes a texture-based segmentation method for very high spatial resolution imagery. Indeed, our main objective is to perform a sparse image representation modeled by a graph and then to exploit the wavelet transform on graph for the final purpose of image segmentation. Here, a set of pixels of interest, called representative pixels, is first extracted from the image and considered as vertices for constructing a weighted graph. Once the wavelet transform on graph is generated, their coefficients serve as textural features and will be exploited for unsupervised segmentation. Experimental results show the effectiveness of the proposed method when applied for very high spatial resolution multi-spectral images in terms of good segmentation precision as well as low complexity requirement.
Familiarization Protocol Influences Reproducibility of 20-km Cycling Time-Trial Performance in Novice Participants

Introduction: Exercise performance is reproducible in experienced athletes; however, less trained participants exhibit greater variability in performance and pacing. To reduce variability, it is common practice to complete a familiarization prior to experimental testing. However, there are no clear guidelines for familiarizing novice participants to a cycling time-trial (TT), and research findings from novice populations may still be influenced by learning effects. Accordingly, the aims of this study were to establish the variability between TTs after administering differing familiarization protocols (duration or type) and to establish the number of familiarization trials required to limit variability over multiple trials. Methods: Thirty recreationally active participants, with no prior experience of a TT, performed a 20-km cycling TT on five separate occasions, after completing either a full (FF, 20-km TT, n = 10), a half (HF, 10-km TT, n = 10) or an equipment familiarization (EF, 5-min cycling, n = 10). Results: Variability of TT duration across five TTs was the lowest after completing FF (P = 0.69, ηp2 = 0.05) compared to HF (P = 0.08, ηp2 = 0.26) and EF (P = 0.07, ηp2 = 0.21). In the FF group after TT2, the effect size for changes in TT duration was small (d < 0.49). There were large differences between later TTs in HF (d = 1.02, TT3-TT4) and EF (d = 1.12, TT4-TT5). The variability in mean power output profiles between trials was lowest within FF, with a similar pacing profile reproduced between TT3-TT5. Discussion: Familiarization of the exercise protocol influenced reproducibility of pacing and performance over multiple, maximal TTs, with best results obtained after a full experience of the exercise compared to HF and EF. The difference of TT1 to later TTs indicates that one familiarization is not adequate in reducing the variability of performance for novice participants. After the FF and an additional TT, performance changes between TTs were small, however, a reproducible pacing profile was not developed until after the FF and two additional TTs. These findings indicate that a minimum of three full familiarizations are necessary for novice participants to limit systematic error before experimental testing.
Squatting Mechanics in People With and Without Anterior Cruciate Ligament Reconstruction

Background: Single-legged squat mechanics change after anterior cruciate ligament (ACL) reconstruction and rehabilitation, but it is unclear if changes in squat mechanics are graft specific. Purpose: To investigate graft differences in biomechanics of the knee, hip, and trunk during the single-legged squat in patients with ACL-reconstructed knees, determine if these factors were associated with deficits in knee extension moment, and determine if subjective knee function and squat biomechanics are related. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 106 individuals were grouped based on surgical status and graft type (51 control, 34 bone–patellar tendon–bone [BPTB], 21 ipsilateral semitendinosus and gracilis autograft [ISGA]). Motion capture interfaced with force plates was used to capture single-legged squat performance in the ACL reconstructed and dominant control limbs. Variables were captured at peak knee flexion. Results: Controls exhibited greater knee extension moment (P = .04), knee flexion (P = .002), and hip adduction angles (P = .04) compared with the reconstructed groups. The ISGA group demonstrated greater forward (P = .01) and lateral (P = .002) trunk flexion over the reconstructed limb. Summated extension moment did not differ between groups (P = .42). Knee extension moment was correlated with lateral trunk flexion (r = −0.31, P = .03) in the control group and knee flexion angle (r = −0.44, P = .04) in the ISGA group. Subjective knee function scores were correlated with lateral trunk flexion (r = −0.45, P = .008) in the BPTB group and with hip adduction angle (r = −0.46, P = .04) and hip extension moment (r = 0.48, P = .03) in the ISGA group. Conclusion: Knee and hip biomechanics were related to surgical status but not graft type. Increased forward and lateral trunk motion in the ISGA group may be a mechanism to protect the knee by minimizing motion during squatting or related to surgical selection bias. Secondary findings (summated extensor moments and correlations) most likely represent a strategy to shift the squat demands from the knee to the hip. Clinical Relevance: Clinicians should target these neuromuscular deficits during rehabilitation and training programs after ACL reconstruction.
Altered Structural and Mechanistic Properties of Mutant Dihydropteridine Reductases (*)

Nine single genetic mutants of rat dihydropteridine reductase (EC 1.6.99.7), D37I, W86I, Y146F, Y146H, K150Q, K150I, K150M, N186A, and A133S and one double mutant, Y146F/K150Q, have been engineered, overexpressed in Escherichia coli and their proteins purified. Of these, five, W86I, Y146F, Y146H, Y146F/K150Q, and A133S, have been crystallized and structurally characterized. Kinetic constants for each of the mutant enzyme forms, except N186A, which was too unstable to isolate in a homogeneous form, have been derived and in the five instances where structures are available the altered activities have been interpreted by correlation with these structures. It is readily apparent that specific interactions of the apoenzyme with the cofactor, NADH, are vital to the integrity of the total protein tertiary structure and that the generation of the active site requires bound cofactor in addition to a suitably placed W86. Thus when the three major centers for hydrogen bonding to the cofactor are mutated, i.e. 37, 150, and 186, an unstable partially active enzyme is formed. It is also apparent that tyrosine 146 is vital to the activity of the enzyme, as the Y146F mutant is almost inactive having only 1.1% of wild-type activity. However, when an additional mutation, K150Q, is made, the rearrangement of water molecules in the vicinity of Lys is accompanied by the recovery of 50% of the wild-type activity. It is suggested that the involvement of a water molecule compensates for the loss of the tyrosyl hydroxyl group. The difference between tyrosine and histidine groups at 146 is seen in the comparably unfavorable geometry of hydrogen bonds exhibited by the latter to the substrate, reducing the activity to 15% of the wild type. The mutant A133S shows little alteration in activity; however, its hydroxyl substituent contributes to the active site by providing a possible additional proton sink. This is of little value to dihydropteridine reductase but may be significant in the sequentially analogous short chain dehydrogenases/reductases, where a serine is the amino acid of choice for this position.
A Generalized Wedelin Heuristic for Integer Programming

A very important ingredient for solving hard general integer programs are heuristics that try to quickly find good feasible solutions. One of these heuristics is Wedelin's algorithm, which works for the limited class of 0-1 integer programs. A big advantage of Wedelin's approach is that it does not depend on a solution of the linear programming (LP) relaxation as many other heuristics do. This makes it extremely fast in practice and makes it easy to use the parallelism of the upcoming multicore CPUs, as in an integer programming (IP) solver it could be applied in parallel to the traditional branch-and-bound algorithm. In this paper, we present several extensions and generalizations to Wedelin's algorithm (most can be handled in an implicit manner without much performance cost) and investigate different ways of improving it. We give all necessary details and parameters. We strive for an algorithm that is faster than other heuristics but achieves comparable solution quality. We evaluate the performance of the algorithm on a large set of more than 100 instances from different sources. The results indicate that our heuristic often finds solutions comparable to or even better than those found using current state-of-the-art heuristics while typically needing only a fraction of their running time. Additionally, we report positive findings on the application of the heuristic on feasibility instances from discrete tomography. Our algorithm always finds the IP optimum in less time than the simplex/barrier algorithms and often in less time than it takes the volume algorithm to find just the LP optimum.
The intermediate filament protein nestin is expressed in the developing kidney and heart and might be regulated by the Wilms ’ tumor suppressor Wt 1

Nestin is an intermediate filament protein originally described in neural stem cells and a variety of progenitor cells. More recently, nestin was detected in rat kidney podocytes. We show here that nestin is expressed in a developmentally regulated pattern in the kidney. Nestin was detected by immunohistochemistry in the condensing mesenchyme surrounding the ureter, in developing glomeruli, in podocytes of the adult kidney, and in a podocyte cell line. Nestin shared a strikingly overlap in expression with the Wilms’ tumor suppressor Wt1. Nestin was significantly up-regulated in a cell line with inducible Wt1 expression upon induction of Wt1. Co-transfection experiments in human embryonic kidney cells (HEK293) revealed stimulation of a nestin intron 2 enhancer element up to 6-fold by the Wt1(-KTS) splice variant. Nestin expression was significantly reduced in an inducible mouse model of glomerular disease. This model is based on podocyte-specific over-expression of Pax2 and associated with a loss of Wt1 expression [33]. Furthermore, also in the developing heart, nestin was found in an overlapping pattern with Wt1 in the epicardium and the forming coronary vessels. Strikingly, in the hearts of Wt1 knockout mice, nestin was barely detectable when compared to the hearts of wild-type embryos. Our results show that nestin is expressed at different stages of kidney and cardiac development and suggest that its expression in these organs might be regulated by the Wilms’ tumor suppressor Wt1.
What Ignites a Reply?: Characterizing Conversations in Microblogs

Nowadays, microblog platforms provide a medium to share content and interact with other users. With the large-scale data generated on these platforms, the origin and reasons of users engagement in conversations has attracted the attention of the research community. In this paper, we analyze the factors that might spark conversations in Twitter, for the English and Spanish languages. Using a corpus of 2.7 million tweets, we reconstruct existing conversations, then extract several contextual and content features. Based on the features extracted, we train and evaluate several predictive models to identify tweets that will spark a conversation. Our findings show that conversations are more likely to be initiated by users with high activity level and popularity. For less popular users, the type of content generated is a more important factor. Experimental results shows that the best predictive model is able obtain an average score $F1=0.80$. We made available the dataset scripts and code used in this paper to the research community via Github.
Precise assessment of noncompliance with the antihypertensive therapy in patients with resistant hypertension using toxicological serum analysis

Background: The aim of our study was to assess the prevalence of pseudo-resistance caused by noncompliance with treatment among patients with severe resistant hypertension and to analyze the contributing factors. Method: Three hundred and thirty-nine patients (195 men) with resistant essential hypertension were studied. The first group consisted of 176 patients admitted for hospitalization for exclusion of a secondary cause to our hypertension centre (103 men); the second one consisted of 163 out-patients (92 men) investigated for the first time in an out-patient hypertension clinic. Unplanned blood sampling for assessment of serum antihypertensive drug concentrations by means of liquid chromatography–mass spectrometry was performed in all patients. Results: Our main finding is a surprisingly low compliance with drug treatment in out-patients with resistant hypertension (23% partially noncompliant and 24% totally noncompliant – in total, 47% prevalence of noncompliance). Eighty-one percent of hospitalized patients were positive, in 10% the results were partially positive and in 9% of the patients, the drugs were all negative. The compliance among hospitalized patients was probably better due to lower numbers of prescribed drugs and expected thorough investigation. More frequently, noncompliance was found in nonworking (potential purpose-built behaviour), younger and less well educated patients. The most frequent noncompliance was to doxazosine, spironolactone and hydrochlorothiazide. We have observed a surprisingly low compliance with treatment among out-patients with severe hypertension. Conclusion: We conclude that the evaluation of antihypertensive drugs concentrations is a useful and precise method for assessment of noncompliance in patients with resistant hypertension. This evaluation is useful before starting the diagnostic work-up of secondary forms of hypertension and before assignment patients into protocols with new therapy modalities such as renal denervation.
X-ray insights into star and planet formation

Although stars and planets form in cold environments, X-rays are produced in abundance by young stars. This review examines the implications of stellar X-rays for star and planet formation studies, highlighting the contributions of NASA’s (National Aeronautics and Space Administration) Chandra X-ray Observatory. Seven topics are covered: X-rays from protostellar outflow shocks, X-rays from the youngest protostars, the stellar initial mass function, the structure of young stellar clusters, the fate of massive stellar winds, X-ray irradiation of protoplanetary disks, and X-ray flare effects on ancient meteorites. Chandra observations of star-forming regions often show dramatic star clusters, powerful magnetic reconnection flares, and parsec-scale diffuse plasma. X-ray selected samples of premain sequence stars significantly advance studies of star cluster formation, the stellar initial mass function, triggered star-formation processes, and protoplanetary disk evolution. Although X-rays themselves may not play a critical role in the physics of star formation, they likely have important effects on protoplanetary disks by heating and ionizing disk gases.
RAD51C (RAD51L2) is involved in maintaining centrosome number in mitosis

The RAD51C (RAD51L2) protein is one out of five RAD51 paralogs and forms a complex that includes either XRCC2 or XRCC3. Both of these complexes may have important functions in homologous recombination (HR). Here, we confirm that the frequency of DNA double-strand break (DSB)-induced HR is reduced in the RAD51C deficient cell line CL-V4B, in agreement with a role for RAD51C in HR. We report that mitotic RAD51C deficient CL-V4B cells also have an increased number of centrosomes in mitosis resulting in aberrant mitotic spindles. These data suggest that the RAD51C protein is important in maintaining correct centrosome numbers and that the complexes including RAD51C and XRCC2 or XRCC3 may be of importance in maintaining correct centrosome numbers in mitosis. Increased centrosome numbers following a RAD51C defect indicates that this protein might be important in preventing aneuploidy, suggesting that it could be a potential tumour suppressor in mammals.
Fourier transform infrared microspectroscopy for the analysis of the biochemical composition of C. elegans worms

ABSTRACT Changes in intermediary metabolism have profound effects on many aspects of C. elegans biology including growth, development and behavior. However, many traditional biochemical techniques for analyzing chemical composition require relatively large amounts of starting material precluding the analysis of mutants that cannot be grown in large amounts as homozygotes. Here we describe a technique for detecting changes in the chemical compositions of C. elegans worms by Fourier transform infrared microspectroscopy. We demonstrate that the technique can be used to detect changes in the relative levels of carbohydrates, proteins and lipids in one and the same worm. We suggest that Fourier transform infrared microspectroscopy represents a useful addition to the arsenal of techniques for metabolic studies of C. elegans worms.
Low occurrence of colistin-resistant Escherichia coli in faecal content of pigs in French commercial herds

Des souches d'Escherichia coli sentinelles ont ete isolees de matieres fecales de porcs presents dans des elevages naisseurs-engraisseurs conventionnes situes en France. Les souches ont ete selectionnees pour leur sensibilite a la colistine. Dans la plupart des elevages de l'etude (13 sur 16) la colistine etait administree aux porcelets en maternite et plus frequemment en post-sevrage. Parmi les 4333 souches testees, 23 souches (dont 22 isolees de porcelets) ont ete classees resistantes par la methode de l'antibiogramme standard et leur resistance a ete confirmee par determination de la CMI (de 4 a 16μg/ml). Ces resultats indiquent que la methode de l'antibiogramme standard est utilisable pour l'evaluation de la resistance a la colistine. De plus, il apparait que l'apparition de souches resistantes a la colistine en contexte d'utilisation est peu frequente.
Rapid prototyping of FPGA based digital controller of DSTATCOM for load compensation under distorted utility condition

This paper presents rapid prototyping of FPGA based digital controller for Distribution STATic COMpensator (DSTATCOM) using Matlab/Simulink and System Generator. The MATLAB/Simulink models are optimized and converted to target-specific synthesized VHDL code for FPGA implementation. Simulation, co-simulation, system level design and verification for rapid prototyping of FPGA-based digital controller are necessary to develop prototype in a relatively short time span by avoiding time-consuming manual coding. This enables increased productivity and facilitates the development of digital controller with more complex control algorithms. This prototype controller is developed and implemented on evaluation boardXUPV5 with Virtex-5 xc5vlx110t chip. This design is verified with System Generator co-simulation platform and found total harmonic distortion of load compensation well within the allowable range of IEEE standards with unit power factor achievement.
Offline writer verification using pen pressure information from infrared image

Writer verification methods from handwriting images have been widely used in biometrics, forensic casework and so on. However, their performance conducted by a computer is still far behind that of human beings. This study proposes an offline writer verification method which uses a new hybrid feature. The characteristics of this new feature are the combination of shape and pen pressure information. For shape information, the authors use the weighted direction code histogram, which is often used in Japanese handwriting recognition and writer verification methods. For pen pressure information, the authors use the texture features of infrared (IR) images obtained from a multi-band image scanner. Although the simple use of pen pressure information encoded in the IR image cannot improve the geometric mean (g-mean)-based error rate, the use of clipping process and second-order statistics can decrease the g-mean-based error rate from 4.8 to 3.2%.