Miracle-dz/UniFAR-FTUs huggingface dataset:
The Best of Both Worlds: An Eclectic Approach to the Use of Computer Technology in Music Education

The term ’computer technology’ as it applies to music education incorporates not only a wide range of microprocessor-based equipment but also an equally-wide range of applications of this equipment. The computer-based hardware ranges from general-purpose microcomputers (with or without specialized music peripheral devices) to dedicated music computer systems, to computer musical instruments (CMIs) such as digital synthesizers, digital samplers and ’drum machines’. With appropriate software the applications of computer technology to music education range from the use of microcomputers for Computer-Assisted Instruction (CAI) or Computer-Aided Learning (CAL) on the one hand to the use of microcomputers and other microprocessor-based devices as personal tools for learning and creativity on the other.
Effect of resin thickness, and curing time on the micro-hardness of bulk-fill resin composites

Background Bulk-fill resin composite has been introduced, their manufacturers claimed that they can be applied in bulks of 4mm, without necessitating a prolonged curing time, or a light curing unit with increased irradiance. Thus this study was conducted to evaluate the effect of resin thickness, and curing time on the micro-hardness of two bulk -fill resin composites; Tetric Evo-Ceram [TE], and X-trafil [XF]. Material and Methods 120 cylindrical specimens were prepared, and divided into 24 groups (n=5/group), representing the two bulk-fill resin composites, three different material thicknesses (2, 3 and 4 mm) and the four curing times used in the study (10, 20, 40, and 60 seconds). The specimens were light-cured from the top surface only. Specimens were stored in light proof containers in complete darkness at 37°C for 24 hours. Micro-hardness test was conducted on both top and bottom surfaces using Vickers micro-hardness tester with 500 g load and a dwell time of 15 seconds. Data were statistically analyzed by Four-way ANOVA of Variance. The significance level was set at P ≤ 0.05. Pearson Correlation used to determine significant correlations between mean micro-hardness (top) and (bottom) surfaces. Results Four way-ANOVA shows that different tested materials produce a statistically significant effect on mean micro-hardness (VHN) at p≤0.001, while thickness, curing time, and surface revealed statistically non significant effect on mean micro-hardness (VHN) at p≥0.05. [XF] (92.01±3.15 VHN) showed statistically significant higher mean micro-hardness than [TE] (54.13±4.96 VHN). Pearson Correlation revealed that there was a significant direct correlation between micro-hardness (bottom) and mean micro-hardness (top) (mm), r = 0.985, p (2-tailed) ≤0.001. Conclusions Within the limitations of this study, the bulk-fill resin composites used in this study can be placed and cured properly in the 4 mm bulk. Key words:Bulk-fill resin composite, micro-hardness, thickness, curing time.
Accurate Power Loss Model Derivation of a High-Current Dual Active Bridge Converter for an Automotive Application

An accurate power loss model for a high-efficiency dual active bridge converter, which provides a bidirectional electrical interface between a 12-V battery and a high-voltage (HV) dc bus in a fuel cell car, is derived. The nominal power is 2 kW, the HV dc bus varies between 240 and 450 V, and the battery voltage range is between 11 and 16 V. Consequently, battery currents of up to 200 A occur at nominal power. In automotive applications, high converter efficiency and high power densities are required. Thus, it is necessary to accurately predict the dissipated power for each power component in order to identify and to properly design the heavily loaded parts of the converter. In combination with measured efficiency values, it is shown that conventional converter analysis predicts substantially inaccurate efficiencies for the given converter. This paper describes the main reasons why the conventional method fails and documents the different steps required to predict the power losses more accurately. With the presented converter prototype, an efficiency of more than 92% is achieved at an output power of 2 kW in a wide input/output voltage range.
Affective style and eating disorders: A field study

Eating disorders (ED) are a heterogeneous group of problems related to restraint and/or overeating. It is proposed that individual differences in affective reactivity and moods (affective style) might be related to these behaviours. Variations in affective style are expressed by differing levels of sensitivity to the motivation systems of approach and avoidance. The present study tested whether a relation exists between ED and variations in the sensitivity of motivational systems as well as mood dispositions. A total of 2020 undergraduate students completed the Eating Disorder Diagnostic Scale (EDDS), the Behavioural Inhibition System and Behavioural Activation System Scales (BIS/BAS), and the Positive and Negative Affect Schedule (PANAS). The results showed a significant within-subject interaction of Alimentary group × Motivation (F=4.056; p<0.007). It was also observed that the Overeating group had lower levels of motivation asymmetry than the Normal (p<0.01) and Restrictive (p<0.005) groups and marginally lower levels than the Purgative group (p<0.07). The study results suggest mainly that the avoidance/inhibition motivational system is related to eating problems connected with overeating, including chronic alimentary restraint (chronic dieters). The theoretical and clinical implications of these findings are discussed.
Impact of traffic mix on caching performance in a content-centric network

For a realistic traffic mix, we evaluate the hit rates attained in a two-layer cache hierarchy designed to reduce Internet bandwidth requirements. The model identifies four main types of content, web, file sharing, user generated content and video on demand, distinguished in terms of their traffic shares, their population and object sizes and their popularity distributions. Results demonstrate that caching VoD in access routers offers a highly favorable bandwidth memory tradeoff but that the other types of content would likely be more efficiently handled in very large capacity storage devices in the core. Evaluations are based on a simple approximation for LRU cache performance that proves highly accurate in relevant configurations.
Patrones de prosodia expresiva en pacientes con enfermedad de Alzheimer

Expressive prosodic patterns in individuals with Alzheimer's Disease. This paper describes a useful technique for quantifying the degree of speech deficits in dementia of GDS 4 Alzheimer's type (DAT). Production of prosodic speech in DAT patients and healthy older controls was analysed using variation in fundamental frequency (F0) measures on a reading task. The prosogram computational model was used to analyze the prosodic contours of the speech samples, using melodic styling of F0 based on perceptual principles and prominence detection of spectral and amplitude fluctuations in the speech signal. Results revealed significant differences in most of these prosodic parameters among the DAT group. Normal pitch variation in speech and variations in syllable timing were reduced in the DAT group, these features cause "flat" speech prosody in these patients. These speech parameters may have diagnostic and prognostic value for Alzheimer's disease and therefore could be a useful aid in clinical trials.
Caloric restriction: conservation of in vivo cellular replicative capacity accompanies life-span extension in mice.

In male mice of a long-lived hybrid strain (B6D2F1), long-term 40% caloric restriction (CR) extended both mean and maximum life spans by 36 and 20%, respectively, over that of ad libitum fed (AL) controls. Measurements of entry into S-phase were made in vivo of six different cell types in five different organs using 2-week exposures to BrdU. The labeling index (L.I.) in all organs studied was lower in young CR mice than in young AL fed mice. In most cases, the L.I. in AL mice fell to the levels of that in the CR mice by 13 months of age, and the two groups then remained so through old age. However, when the L.I. was measured in old CR mice which had been placed on the AL diet for a period of 4 weeks (this was termed refeeding (RF), it was found to be above that of similar age AL or CR mice and almost at the level of young AL mice. This was still true, but to a lesser degree, in a repeat study using an 8-week period of RF. In a separate but parallel in vitro study (companion paper, this volume), the superiority of CR over AL for retention of cellular replication capacity was confirmed by clone size distribution measurements made in several cell types in mice of several age groups. These results indicate that: (1) the rate of cell replication in AL diet mice diminishes greatly by early middle age in all organ sites studied and then plateaus or declines much more slowly; (2) CR broadly preserves in vivo cellular replicative capacity but often requires the energy levels provided by a switch to AL feeding to demonstrate this late in life; (3) accordingly, the replicative deficit in AL fed mice appears to be cumulative and is significant only in old age. The mechanism(s) involved is yet to be discovered but may be related to, or even the same as, that which extends life spans in CR animals. Correspondingly, and with corroborative data from our in vitro companion study, (W. R. Pendergrass et al., 1995. Exp. Cell. Res. 217, 309-316), we suggest that cell populations sustain an accrual of biochemical damage or physiological alterations which increasingly limit their replicative capacity as the animal ages, and that CR reduces the accrual of this damage.
Virtual proximity and facial expressions of computer agents regulate human emotions and attention

Emotion‐ and attention‐related subjective and physiological responses to virtual proximity and facial expressions of embodied computer agents (ECA) were studied. Thirty participants viewed female and male characters with a neutral, unpleasant, or pleasant facial expression. Agents' size was used to simulate three levels of proximity. Participants' electrical facial muscle and heart activity were registered, and subjective ratings of emotional and attentional experiences collected. Unpleasant and large (i.e., closer) agents were more alerting (i.e., unpleasant, arousing, and dominating) and attracted more stimulus‐driven attention than neutral, pleasant, and smaller (i.e., further away) agents. Pleasant agents attracted more voluntary attention than neutral and unpleasant agents. Heart rate (HR) responded to agent proximity, while the valence of the agent affected electrical facial muscle activity. Thus, the imitation of human social emotional cues in embodied computer agents (ECAs) could be used to regulate human–computer interaction. Copyright © 2010 John Wiley & Sons, Ltd.
G‐Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1

Metastatic spread in Ewing sarcomas (ES) is frequent and haematogenous. G‐protein coupled receptor 64 (GPR64), an orphan receptor with normal expression restricted to human epididymis is specifically over‐expressed in ES among sarcoma, but also up‐regulated in a number of carcinomas derived from prostate, kidney or lung. Inhibition of GPR64 expression in ES by RNA interference impaired colony formation in vitro and suppressed local tumour growth and metastasis in Rag2−/−γC−/− mice. Microarray analysis after GPR64 knock down revealed a GPR64‐mediated repression of genes involved in neuronal development like SLIT, drosophila, homolog of, 2 (SLIT2), and genes regulating transcription including pre‐B cell leukemia homeobox 2 (PBX2). Concurrently, the suppression of GPR64 increased ES susceptibility to TRAIL induced apoptosis. Moreover, a GPR64‐mediated induction of placental growth factor (PGF) in ES was observed. PGF suppression by RNA interference resulted in a reduction of metastatic growth similar to that observed after GPR64 knock down. Importantly, inhibition of GPR64 as well as PGF expression was associated with a reduced expression of matrix metalloproteinase (MMP) 1 and invasiveness in vitro. Furthermore, MMP1 knock down abrogated lung metastasis in Rag2−/−γC−/− mice. Thus, GPR64 expression in ES maintains an immature phenotype that is less sensitive to TRAIL‐induced apoptosis and via its up‐regulation of PGF and MMP1 orchestrates and promotes invasiveness and metastatic spread. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
BMP9 induces osteogenesis and adipogenesis in the immortalized human cranial suture progenitors from the patent sutures of craniosynostosis patients

The cranial suture complex is a heterogeneous tissue consisting of osteogenic progenitor cells and mesenchymal stem cells (MSCs) from bone marrow and suture mesenchyme. The fusion of cranial sutures is a highly coordinated and tightly regulated process during development. Craniosynostosis is a congenital malformation caused by premature fusion of cranial sutures. While the progenitor cells derived from the cranial suture complex should prove valuable for studying the molecular mechanisms underlying suture development and pathogenic premature suture fusion, primary human cranial suture progenitors (SuPs) have limited life span and gradually lose osteoblastic ability over passages. To overcome technical challenges in maintaining sufficient and long‐term culture of SuPs for suture biology studies, we establish and characterize the reversibly immortalized human cranial suture progenitors (iSuPs). Using a reversible immortalization system expressing SV40 T flanked with FRT sites, we demonstrate that primary human suture progenitor cells derived from the patent sutures of craniosynostosis patients can be efficiently immortalized. The iSuPs maintain long‐term proliferative activity, express most of the consensus MSC markers and can differentiate into osteogenic and adipogenic lineages upon BMP9 stimulation in vitro and in vivo. The removal of SV40 T antigen by FLP recombinase results in a decrease in cell proliferation and an increase in the endogenous osteogenic and adipogenic capability in the iSuPs. Therefore, the iSuPs should be a valuable resource to study suture development, intramembranous ossification and the pathogenesis of craniosynostosis, as well as to explore cranial bone tissue engineering.
The Policing of Families

In "The Policing of Families", Jacques Donzelot, a student and colleague of Michel Foucault, offers an account of public intervention in the regulation of family affairs since the 18th century, showing how this intervention effected radical changes in the structure of what had traditionally been a private domain. Treating the family as a focal point of a multitude of social practices and discourses, Donzelot examines the role of philanthropy, social work, compulsory mass education, and psychiatry in the contol of family life, and describes the transformation of mothers into agents of the state. Donzelot also provides a critique of Marxist, psychoanalytic and feminist conceptions of the family and shows how the policies of the state and the professions moulded working-class and middle-class families in quite different ways.
Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated

Summary Cullin4, Ddb1 and Cdt2 are core subunits of the ubiquitin ligase complex CRL4Cdt2, which controls genome stability by targeting Spd1 for degradation during DNA replication and repair in fission yeast. Spd1 has an inhibitory effect on ribonucleotide reductase (RNR), the activity of which is required for deoxynucleotide (dNTP) synthesis. The failure to degrade Spd1 in mutants where CRL4Cdt2 is defective leads to DNA integrity checkpoint activation and dependency. This correlates with a lower dNTP pool. Pools are restored in a spd1-deleted background and this also suppresses checkpoint activation and dependency. We hypothesized that fission yeast with RNR hyperactivity would display a mutator phenotype on their own, but also possibly repress aspects of the phenotype associated with the inability to target Spd1 for degradation. Here, we report that a mutation in the R1 subunit of ribonucleotide reductase cdc22 (cdc22-D57N), which alleviated allosteric feedback inhibition, caused a highly elevated dNTP pool that was further increased by deleting spd1. The &Dgr;spd1 cdc22-D57N double mutant had elevated mutation rates and was sensitive to damaging agents that cause DNA strand breaks, demonstrating that Spd1 can protect the genome when dNTP pools are high. In ddb1-deleted cells, cdc22-D57N also potently elevated RNR activity, but failed to allow cell growth independently of the intact checkpoint. Our results provide evidence that excess Spd1 interferes with other functions in addition to its inhibitory effect on ribonucleotide reduction to generate replication stress and genome instability.
The use of a narrative story stem technique with maltreated children: Implications for theory and practice

Abstract Maltreatment can impact the earliest stages of development during which time patterns of emotion regulation and attachment begin to be established (Carlson, Cicchetti, Barnett, & Braunwald, 1989b; Cicchetti, Ganiban, & Barnett, 1991). These disruptive patterns are problematic for early moral development and are likely to play a role in the development of conduct disorders (Aber & Cicchetti, 1984). Thus, maltreated children are clearly in a high-risk situation. To examine emotion regulation, internal representations of relationships, and early moral development, the use of a play narrative story stem technique (Bretherton, Ridgeway, & Cassidy, 1990; Buchsbaum & Emde, 1990) with maltreated children and a nonmaltreated disadvantaged comparison group of children is described. Representative case examples from each group are used to illustrate the effectiveness of this technique for eliciting themes about family relationships, conflicts, and their resolution or lack thereof as well as defenses and coping styles. The potential usefulness of this paradigm for clinical assessment and intervention are discussed.
Non-central Cameras for 3D Reconstruction Thesis Proposal

An apparatus for the high-frequency artificial respiration of living animals or human beings has a flexible endotracheal tube for introduction into the trachea thereof. The flexible endotracheal tube has an outlet end, a valve at the outlet end and control and air supplies along the endotracheal tube to the valve. The control operates the valve to produce steep-flanked respiratory-air pulses. The valve can serve simultaneously for removing used air through a conventional endotracheal tube as a sleeve about the other endotracheal tube.
An FPGA design and implementation framework combined with commercial VLSI CADs

Conventional full-custom reconfigurable logic device design and implementation are time consuming processes. In this research, we propose a design framework in order to improve FPGA IP core design efficiency by link academic FPGA design flow and commercial VLSI CADs based on the synthesizable method. A novel FPGA routing tool is developed in this framework, namely the EasyRouter. By using simple templates, EasyRouter can automatically generate the HDL codes and the configuration bitstream for an FPGA. With this design flow, accurate physical information can be reported when a new FPGA architecture is evaluated with reliable commercial VLSI CADs. For FPGA architectures that cannot be easily implemented with present VLSI process, EasyRouter provides a fast performance analysis flow, which improved delay accuracy 5.1 times than VPR on average.
Anywhere On-Keyboard Password technique

Traditional authentication technique generally requires an id and password to verify the identity of user. By nature, user is looking for a password that is easy to remember and secured from any attack. However, remembering many complicated passwords, especially when user has different accounts, is not an easy task. Moreover, Traditional technique is still vulnerable to attack such as hidden camera. To overcome these drawbacks, we propose a new password authentication technique called “Anywhere On-Keyboard Password (AOKP)”. The experiment results show that 40% of the spies succeed to catch the password shape but all of them fail to detect the number of the strokes. Therefore, the proposed technique provides more secure and memorable authentication method through changing password from text to mix shape and number of strokes. In addition, it has high level of scalability and simplicity though the freedom of writing the password anywhere on keyboard, password length and language independent.
Laparoscopic Splenectomy and Lymph Node Biopsy for Hematologic Disorders

ObjectiveThe authors audit the introduction of laparoscopic splenectomy and laparoscopic intra-abdominal lymph node biopsy and compare outcomes with a parallel cohort of patients undergoing open splenectomy. Summary Background DataLaparoscopic splenectomy was first reported in 1992. It was introduced into clinical practice at the Royal Brisbane Hospital in 1991. Between June 1991 and March 1994, 24 patients have undergone laparoscopic splenectomies and 23 patients have had laparoscopic intra-abdominal lymph node biopsies. MethodsLaparoscopic splenectomy was performed using a four- or five-port technique. The splenic hilum was secured using a linear stapler cutter, and the spleen was removed after placing it in a laparoscopic bag. Lymph node biopsy was performed using a three- or four-port technique, depending on the site and size of the lymphadenopathy. ResultsLaparoscopic splenectomy was completed in 22 patients (92%). Median hospital stay was 3 days (range 2–7 days) and morbidity occurred in two patients (8%). Lymph node biopsy was completed teparoscopically in 21 of 23 patients (91 %), with morbidity in two cases (9%). Median hospital stay was 2 days (range 1–6 days), with a diagnostic accuracy of 90%. Comparison with open splenectomy revealed that the laparoscopic approach took significantly longer to perform (p = 0.0002). but resulted in a significantly shorter hospital stay (p = 0.0005). ConclusionsBoth laparoscopic splenectomy and laparoscopic lymph node biopsy currently are used as the treatments of choice for hematologic disease in our institution.