Miracle-dz/UniFAR-FTUs huggingface dataset:
Inflammation after embolization of intracranial aneurysms.

Angiographic recanalization of embolized intracranial aneurysms occurs in a significant number of patients. In recent years, different coil modifications have been introduced to decrease recanalization rates. The two main coil modifications currently available for clinical application include polyglycolic acid/polylactic acid coating to trigger a “more aggressive” inflammatory reaction (Matrix, Boston Scientific; Cerecyte, Micrus; and Nexus, MicroTherapeutics), and coating with an expandable gel to achieve a tighter packing of the aneurysm (HydroCoil, MicroVention). With the widespread introduction of these coil modifications, unexpected adverse effects have been observed in some patients, while the effectiveness of these devices in improving recanalization rates has yet to be convincingly demonstrated. In their article, Fanning and coworkers report their observations in a large cohort of patients with ruptured and unruptured intracranial aneurysms who received follow-up with magnetic resonance (MR) imaging studies after endovascular treatment. The goal of the study was to assess the degree, pattern, and course of MR imaging changes induced by coil embolization. The main findings of this study are as follows: 1) enhancement of the aneurysm wall on MR imaging was not uncommon after endovascular treatment (31.5% of patients); 2) de novo perianeurysmal edema developed in 8.9% of treated unruptured aneurysms; 3) communicating hydrocephalus occurred in 18% of unruptured aneurysms treated with HydroCoils; and 4) the observed MR imaging changes were much more common after embolization with HydroCoils. Aneurysm wall enhancement is probably a reflection of the inflammatory reaction triggered by coil embolization. Postmortem histological analysis of intracranial aneurysms treated with coil embolization demonstrates an inflammatory reaction starting at the periphery of the sac and proceeding centripetally toward the center. 1,10,13 A denser infiltration of the fibrin layer by polymorphonuclear neu
The CAESAR project: a 3-D surface anthropometry survey

The CAESAR study (Civilian American and European Surface Anthropometry Resource) is a survey of body measurements for people ages 18-65 in three countries: USA, The Netherlands, and Italy. It is a collaborative effort with partners from several countries and many industries. It employs the latest in 3D measurement technology, and is the first 3D surface anthropometry survey of the US and Europe. Data from the study will allow us to effectively design everything from better fitting clothes and protective equipment to better seats and workstations, as well as dramatically reducing the cost to design and manufacture them.
Family Firms and the Stock Market Performance of Acquisitions and Divestitures

Research Summary This paper explores the stock market performance of acquisitions and divestitures where both, one, or neither of the companies in the transaction are family firms. We find that acquirer shareholder returns are highest when family firms buy businesses from non‐family firm divesters, especially when family chief executive officer (CEO) acquirers buy businesses from non‐family CEO divesters. Additionally, divester shareholder returns are highest when family firms sell businesses to non‐family firm acquirers, especially when family CEO divesters sell businesses to non‐family CEO acquirers. These findings reveal that it is important to consider the characteristics of both the acquiring and divesting firms when analyzing acquisition and divestiture performance, and that the expected gains to family firm acquisitions and divestitures are driven by transactions in which the counterparties are non‐family firms. Managerial Summary This paper explores how investors react to acquisitions and divestitures where both, one, or neither of the companies in the deal are family firms. The stock market performance of acquiring firms is highest when family firms buy businesses from non‐family firms, relative to the other three possible combinations of family and non‐family firm acquirers and divesters. Likewise, the stock market performance of divesting firms is highest when family firms sell businesses to non‐family firms, again relative to the other three possible combinations of family and non‐family acquirers and divesters. These findings suggest that investors take into consideration the identities of both the acquiring and divesting firms when evaluating acquisitions and divestitures, and that this has significant implications for the expected performance gains of these transactions.
Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. We sequenced nine exomes and transcriptomes, and two genomes of GISTs for integrated analyses. We detected 306 somatic variants in nine GISTs and recurrent protein-altering mutations in 29 genes. Transcriptome sequencing revealed 328 gene fusions, and the most frequently involved fusion events were associated with IGF2 fused to several partner genes including CCND1, FUS, and LASP1. We additionally identified three recurrent read-through fusion transcripts: POLA2-CDC42EP2, C8orf42-FBXO25, and STX16-NPEPL1. Notably, we found intragenic deletions in one of three exons of the VHL gene and increased mRNAs of VEGF, PDGF-β, and IGF-1/2 in 56% of GISTs, suggesting a mechanistic link between VHL inactivation and overexpression of hypoxia-inducible factor target genes in the absence of hypoxia. We also identified copy number gain and increased mRNA expression of AMACR, CRIM1, SKP2, and CACNA1E. Mapping of copy number and gene expression results to the KEGG pathways revealed activation of the JAK-STAT pathway in small intestinal GISTs and the MAPK pathway in wild-type GISTs. These observations will allow us to determine the genetic basis of GISTs and will facilitate further investigation to develop new therapeutic options.
On the Far Reaching Effects of Using Biased Estimates of Score Reliability: An Examination of the Problem in 20 Data Analyses

Violation of either of two basic assumptions in classical test theory may lead to biased estimates of reliability. Violation of the assumption of essential tau-equivalence may produce underestimates, and the presence of correlated errors among measurement units may result in overestimates. The ubiquity of circumstances in which this problem may occur is not fully comprehended by many workers. This article surveys a variety of settings in which biased reliability estimates may be found in an effort to increase awareness of the prevalence of the problem.
Proteomic analysis of rat hippocampal plasma membrane: characterization of potential neuronal‐specific plasma membrane proteins

The hippocampus is a distinct brain structure that is crucial in memory storage and retrieval. To identify comprehensively proteins of hippocampal plasma membrane (PM) and detect the neuronal‐specific PM proteins, we performed a proteomic analysis of rat hippocampus PM using the following three technical strategies. First, proteins of the PM were purified by differential and density‐gradient centrifugation from hippocampal tissue and separated by one‐dimensional electophoresis, digested with trypsin and analyzed by electrospray ionization (ESI) quadrupole time‐of‐flight (Q‐TOF) tandem mass spectrometry (MS/MS). Second, the tryptic peptide mixture from PMs purified from hippocampal tissue using the centrifugation method was analyzed by liquid chromatography ion‐trap ESI‐MS/MS. Finally, the PM proteins from primary hippocampal neurons purified by a biotin‐directed affinity technique were separated by one‐dimensional electrophoresis, digested with trypsin and analyzed by ESI‐Q‐TOF‐MS/MS. A total of 345, 452 and 336 non‐redundant proteins were identified by each technical procedure respectively. There was a total of 867 non‐redundant protein entries, of which 64.9% are integral membrane or membrane‐associated proteins. One hundred and eighty‐one proteins were detected only in the primary neurons and could be regarded as neuronal PM marker candidates. We also found some hypothetical proteins with no functional annotations that were first found in the hippocampal PM. This work will pave the way for further elucidation of the mechanisms of hippocampal function.
Joint effects of inflammation and androgen metabolism on prostate cancer severity

Multiple pathways of prostate carcinogenesis have been proposed, including those involving androgen metabolism and inflammation. These pathways are not independent, and may act together in prostate cancer etiology: androgens promote both inflammatory processes and serve as mitogens in prostate tumor growth. To explore the possible joint effects of these pathways in prostate cancer severity, we studied 1,090 Caucasian prostate cancer cases to evaluate whether tumor severity is influenced by a history of benign prostatic hyperplasia (BPH) interacting with genotypes involved in inflammation or androgen metabolism including MSR1, RNASEL, AR, CYP3A4, CYP3A43, CYP3A5 and SRD5A2. We observed a statistically significant interaction between a number of genotypes and BPH. After considering the potential for false positive associations, the only remaining significant associations involved CYP3A43 P340A genotypes and history of BPH on both Gleason grade (interaction p‐value = 0.026) and tumor stage (interaction p‐value = 0.017). These results suggest that androgen metabolism may act in concert with inflammatory phenotypes such as BPH in determining prostate cancer severity. © 2008 Wiley‐Liss, Inc.
Evaluation of propofol and remifentanil for intravenous sedation for reducing shoulder dislocations in the emergency department

Objectives: To assess the combination of propofol and remifentanil for sedation to reduce shoulder dislocations in an ED. Methods: Eleven patients with anterior glenohumeral dislocation were given propofol 0.5 mg/kg and remifentanil 0.5 μg/kg iv over 90 seconds and then further doses of 0.25 mg/kg and 0.25μg/kg, respectively, if needed. Another practitioner attempted reduction using the Milch technique. Results: Reduction was achieved in all patients within four minutes of giving sedation (range 0.3–4; mean 1.6). Seven required one attempt at shoulder reduction, three required two attempts, and one required three attempts. Mean time to recovery of alert status was three minutes (range 1–6). The mean pain score during the reduction was 1.7 out of 10 (range 0–5). Nine patients had full recall, one had partial recall, and one had no recall at all. Eight patients were “very satisfied” with the sedation and three were “satisfied”. There were no respiratory or haemodynamic complications that required treatment. Conclusions: Propofol and remifentanil provide excellent sedation and analgesia for the reduction of anterior glenohumeral dislocation, enabling rapid recovery.
TCP-AFEC: An adaptive FEC code control for end-to-end bandwidth guarantee

Recently TCP is often used for video streaming applications. Since TCP congestion control is designed to be responsible for varying network conditions, its sending rate adaptation results in throughput fluctuations and leads to poor video quality. To address the problem, a FEC scheme is useful. Since lost packets can be recovered by redundant packets and are concealed from TCP, TCP can maintain higher throughput. To effectively utilize the FEC scheme, the redundancy level has to be appropriately determined so that redundant packets do not waste network bandwidth. Although many dynamic FEC mechanisms are proposed, these mechanisms are not appropriate for TCP video streaming because they do not try to satisfy the required rate. In this paper, we propose a new adaptive FEC scheme called TCP-AFEC that optimizes extra bandwidth usage for the redundancy level. Simulation evaluations show that the proposed mechanism performs better than previous FEC control approaches in various network conditions.
Multi-objective optimization for computation offloading in mobile-edge computing

Mobile-edge cloud computing is a new cloud platform to provide pervasive and agile computation augmenting services for mobile devices (MDs) at anytime and anywhere by endowing ubiquitous radio access networks with computing capabilities. Although offloading computations to the cloud can reduce energy consumption at the MDs, it may also incur a larger execution delay. Usually the MDs have to pay cloud resource they used. In this paper, we utilize queuing theory to bring a thorough study on the energy consumption, execution delay and price cost of offloading process in a mobile-edge cloud system. Specifically, both wireless transmission and computing capabilities are explicitly and jointly considered when modelling the energy consumption and delay performance. Based on the theoretical analysis, the multi-objective optimization problem is formulated with the joint objectives to minimize the energy consumption, execution delay and price cost by finding the optimal offloading probability and optimal transmission power for each MD. The scalarization scheme and interior point method are applied to address the formulated problem. Through extensive simulations, the effectiveness of the proposed scheme can be demonstrated.
Neurogliaform cells and other interneurons of stratum lacunosum‐moleculare gate entorhinal–hippocampal dialogue

The stratum lacunosum‐moleculare of the hippocampus is an area of integration that receives inputs from extrinsic excitatory fibres including those from the entorhinal cortex, and is under the control of several neuromodulators. A critical aspect is the presence in this hippocampal layer of specific interneurons that are likely to influence the strength and the temporal structure of entorhinal–CA1 hippocampal dynamics. I review here recent data on the physiological role of these interneurons. Special focus is devoted to one interneuron type, the so‐called neurogliaform cell, because recent studies have defined its unusual mode of cell‐to‐cell communication. Neurogliaform cells mediate feedforward inhibition of CA1 pyramidal cells, form a network of cells connected via chemical and electrical synapses, and evoke slow inhibitory synaptic currents mediated by GABAA and GABAB receptors. The modulation of entorhinal input by neurogliaform cells and their contribution to network theta rhythm are also discussed. I hope that novel information on neurogliaform cells will contribute to the ever‐growing appreciation of GABAergic cell type diversity, and will inspire neuroscientists interested not only in synaptic physiology but also in the brain's spatial representation system.
Enrichment medium for isolation of Campylobacter jejuni-Campylobacter coli

A broth enrichment medium for the improvement of isolation of Campylobacter jejuni-Campylobacter coli from stool samples and other specimens is presented. Of 1,228 samples examined in parallel, positive results were obtained from 81 by direct inoculation of selective media and from 112 after enrichment. Thus, an increase of 27.7% in the isolation rate was obtained by using the enrichment medium. The same medium without antibiotics allows the preservation of isolates of C. jejuni-C. coli for at least 2 months at 4 degrees C.
Radiometric Correction and Feature Extraction of Molecular Hyperspectral Imaging Data

Some molecular hyperspectral images of retina sections were collected. Due to the infection of lamp, a spectral curve extracted directly from the original hyperspectral data can not truly present biochemical character. The main preprocessing step of the hyperspectral data is radiometric correction. The paper provides the gray correction coefficient algorithm to eliminating the influence. Because hyperspectral data cube includes a great deal of single band image, data redundancy is very serious. The paper cites that PCA(Principal Component Analysis) algorithm can validly extract feature information and eliminate data redundancy and achieve dimensionality reduction.
Image based measurements for evaluation of pelvic organ prolapse

Magnetic resonance imaging (MRI) measurements are essential for the diagnosis of pelvic organ prolapse given the inaccuracy of clinical examination. However, MRI pelvic floor measurements are currently performed manually and can be inconsistent and time-consuming. In this paper, we present a scheme for semi-automatic measurement modeling on MRI based on image segmentation and intersecting point identification methods. The segmentation algorithm is a multi-stage mechanism based on block grouping, support vector machine classification, morphological operation and prior shape information. Block grouping is achieved by classifying blocks as bone or background based on image texture features. The classified blocks are then used to find the initial segmentation by the first phase morphological opening. Prior shape information is incorporated into the initial segmentation to obtain the final segmentation using registration with the similarity type transformation. After segmentation, points of reference that are used for pelvic floor measurements are identified using morphological skeleton operation. The experiments on the MRI images show that the presented scheme can detect the points of reference on the pelvic floor structure to determine the reference lines needed for the assessment of pelvic organ prolapse. This will lead towards more consistent and faster pelvic organ prolapse diagnosis on dynamic MRI studies, and possible screening procedures for predicting predisposition to pelvic organ prolapse by radiologic evaluation of pelvic floor measurements.
Analogue Adaptive Feedback Lineariser

A solid-state power amplifier (SSP A) linearisation technique based on the analogue implementation of the LMS algorithm is here presented. This technique leads to a linearisation scheme next to an hyperstable adaptive system, thus being suitable for the compensation of SSPA parameter variations. The lineariser is experimented on a class-A power amplifier backed-off by 3 dB.
Key factors for successful corporate entrepreneurship: a study of Indonesian contractors

Abstract Corporate entrepreneurship (CE) is considered as an effective means to support the success of business in a competitive market. Although CE can be a solution for contractors to come up with the right corporate strategy, the concept of CE is very new and there is very little guidance. This paper is aimed at clarifying the CE concept for contractors and identifying key factors for CE in order to enable the implementation. To address this, firstly theoretical concepts and previous research on CE were explored, followed by 19 interviews with top managers of contractors in Indonesia. The data was analysed using thematic analysis to identify the key factors for successful CE in Indonesian contracting business. 21key factors of CE have been identified, which are discussed under five categories: autonomy, competitive aggressiveness, innovativeness, proactiveness and risk taking. All these key factors are found to be related to one another and hence have to be managed as a system for successful CE.
Role of Papillomavirus E1 Initiator Dimerization in DNA Replication

ABSTRACT Viral initiator proteins are polypeptides that form oligomeric complexes on the origin of DNA replication (ori). These complexes carry out a multitude of functions related to initiation of DNA replication, and although many of these functions have been characterized biochemically, little is understood about how the complexes are assembled. Here we demonstrate that loss of one particular interaction, the dimerization between E1 DNA binding domains, has a severe effect on DNA replication in vivo but has surprisingly modest effects on most individual biochemical activities in vitro. We conclude that the dimer interaction is primarily required for initial recognition of ori.
Consumption of non-alcoholic beverages and prostate cancer risk

Our objective was to investigate the relations between the consumption of coffee, tea and carbonated beverages and the development of prostate cancer. The design was a population-based case–control study set in Montreal. The analysis was restricted to the subset of men, aged 45–70 years, who underwent interviews in which aspects of lifelong consumption of non-alcoholic beverages were ascertained. There were 399 incident cases of prostate cancer, 476 population controls and 621 cancer controls. There was no association between the consumption of either coffee or carbonated beverages and the development of prostate cancer. Among daily tea drinkers, the odds ratio associated with the highest tertile of cumulative consumption was 2.0 (95% confidence interval (CI) 1.3–3.0) when using population controls and 1.6 (95% CI 1.0–2.4) when using cancer controls. In conclusion, the consumption of coffee or carbonated beverages does not influence the risk of prostate cancer. Our findings provide no support to the hypothesis that tea consumption may be protective. While tea consumption may increase prostate cancer risk, we were unable to rule out alternative explanations for the positive association that we observed.
Understanding Mobile Payment Service Continuous Use Intention: An Expectation - Confirmation Model and Inertia

Purpose: With significant interest in mobile payment service(MPS), the amount of research on MPS has increased. However, prior studies have focused on users’ first use adoption of MPS. Considering the length of time that has passed since MPSs were first introduced, it has become necessary to investigate usres’ continuous use intentions of MPS. Therefore, in this research, we aim to verify which factors are influensive on continuous use intention of MPS. Methodology/Approach: To achieve purpose, we adopt the expectation-confirmation model(ECM) and inertia. Also, we arranged our research in South Korea where has well developed market of MPS. We applied structural equation model to verify the hypothesis and conducted a survey on consumer who had an experiecne with MPS before. Findings: The findings of this study highlight that importance of perceived usefulness. In this research, percieved usefulness have a significant effect on satisfaction and continuous use intention. Also, our findings emphasize the significant effect of inertia on the continuous use intention of an MPS. These findings have somethig in common with previous researches. Research Limitation/implication: Because young user constitutes the majority of the respondents, generalizing the finding to individuals of all ages is difficult. Further, we only colledcted sample data form MPS usres in South Korea. Consumer perceptions and therir effects on intention may differ from culture to culture. The robustness of these results may be enhanced by replicating the study across various cultures and multiple consumer age groups. Also, because the previous study which is verifying effect of ECM on MPS is scant, theoretical basis seemed not that much robust. On this study, we struggle to build relationship adapting Inforamtion System (IS) context to MPS environment. On the further study, we expect additional reseraches which are using ECM on various IS environment. Originality/Value of paper: This paper is an early research verfiying influencial factors on continuous use intention of MPS. This attempts and research of findings enable to offer timely advice to manager of MPS. Also, we struggle to apply concept of inertia to MPS environment to reflect more actual behavior of consumers.