Miracle-dz/UniFAR-FTUs huggingface dataset:
Physicians' Use of Clinical Information Systems in the Discharge Process: An Observational Study

This study has been performed in order to categorize and measure usage of different information sources and types in a well defined stage of clinical work. The underlying motivation is to improve computer-supported presentation and retrieval of relevant information and to be able to evaluate the functionality of a future improved interface to the electronic patient record (EPR). By observing and analyzing 52 discharge processes, we have seen that the EPR is primarily used for background information and verification. There is a large potential for improved EPR systems that support the clinicians in the plan/future part of the discharge.
Deep Constrained Local Models for Facial Landmark Detection

Among the well-established methods for facial landmark detection is the family of Constrained Local Models (CLMs). An important part of CLM landmark alignment pipeline are the local detectors that estimate the alignment probability of each individual landmark over the facial region. In this paper we present Deep Constrained Local Model (DCLM) algorithm and the novel Dense-Projection Network (DPN) as a local detector. DPN is a deep neural network that consists of two important layers: Template Projection layer and Dense Aggregate layer. In Template Projection layer, patches of facial region are mapped to a higher dimensional space allowing the pose and rotation variations to be captured accurately. In Dense Aggregate layer an ensemble of experts is simulated within one network to make the landmark localization task more robust. In our extensive set of experiments we show that DPNs outperform previously proposed local detectors. Furthermore, we demonstrate that our proposed DCLM algorithm is stateof-the-art in facial landmark detection. We significantly outperform competitive baselines, that use both CLM-based and cascaded regression approaches, by a large margin on three publicly-available datasets for image and video landmark detection.
Analysis of the Role of Ubiquitin-interacting Motifs in Ubiquitin Binding and Ubiquitylation*[boxs]

The ubiquitin-interacting motif (UIM) is a short peptide motif with the dual function of binding ubiquitin and promoting ubiquitylation. This motif is conserved throughout eukaryotes and is present in numerous proteins involved in a wide variety of cellular processes including endocytosis, protein trafficking, and signal transduction. We previously reported that the UIMs of epsin were both necessary and sufficient for its ubiquitylation. In this study, we found that many, but not all, UIM-containing proteins were ubiquitylated. When expressed as chimeric fusion proteins, most UIMs promoted ubiquitylation of the chimera. In contrast to previous studies, we found that UIMs do not exclusively promote monoubiquitylation but rather a mixture of mono-, multi-, and polyubiquitylation. However, UIM-dependent polyubiquitylation does not lead to degradation of the modified protein. UIMs also bind polyubiquitin chains of varying lengths and to different degrees, and this activity is required for UIM-dependent ubiquitylation. Mutational analysis of the UIM revealed specific amino acids that are important for both polyubiquitin binding and ubiquitin conjugation. Finally we provide evidence that UIM-dependent ubiquitylation inhibits the interaction of UIM-containing proteins with other ubiquitylated cellular proteins. Our results suggest a new model for the ubiquitylation of UIM-containing proteins.
Blog Content and Structure, Cognitive Style and Metacognition

Fifty blogs were analysed and classified according to both their content and formal structure. The SOLAT questionnaire, aimed at assessing the right i.e., intuitive-holistic vs. left i.e., systematic-analytical thinking style, was put online, and blog owners were asked to complete it in order to match their cognitive style to the "style" of their blog. Respondents were also asked some metacognitive questions in order to explore their awareness of the psychological processes that are activated by the blog that they had devised, both in their own and in other people's mind. Results showed that blog owners are able to use effective communication strategies by differentiating the formal structure of bogs according to the content, but they lack metacognitive awareness about the mental processes activated by the blog. No relationship between the blog owner's cognitive style and blog style was found. Implications for the educational use of blogs are discussed.
Designing, Playing, and Performing with a Vision-based Mouth Interface

The role of the face and mouth in speech production as well as non-verbal communication suggests the use of facial action to control musical sound. Here we document work on the Mouthesizer, a system which uses a headworn miniature camera and computer vision algorithm to extract shape parameters from the mouth opening and output these as MIDI control changes. We report our experience with various gesture-to-sound mappings and musical applications, and describe a live performance which used the Mouthesizer interface.
Perceptual space and adjective rating of sinusoidal vibrations perceived via mobile device

In the past five years, how to utilize the haptics technology in the mobile device to improve its limited user interface has emerged as an attractive research topic. In this paper, we report two kinds of perceptual data related to vibrotactile signals perceived through a mobile device held in the hand. In Experiment I, we estimated perceptual dissimilarities between sinusoidal vibrations with seven frequencies in 40–250 Hz and two amplitudes of 30 and 40 dB SL. Multi-dimensional scaling was then applied to the perceptual distances, and led to a two-dimensional perceptual space. In the perceptual space, the vibrations of the two amplitudes formed distinct groups. The two groups showed similar structures with respect to the frequency variation. In particular, two perceptual dimensions that spanned a low frequency range (40–100 Hz) and a high frequency range (100–250 Hz) were close to be orthogonal. In Experiment II, we evaluated the subjective qualities of sinusoidal vibrations with different frequencies via adjective rating. Thirteen adjective pairs were carefully selected, and rated for the sinusoidal vibrations played through the mobile device. The results were regressed to the perceptual space, revealing several adjective pairs that can largely account for the distributions of vibration points in the perceptual space, such as ‘dark-bright,’ ‘dull-clear,’ ‘slow-fast,’ ‘vague-distinct,’ ‘thick-thin,’ and ‘heavy-light. ’ The findings of this paper can help understand the perceptual characteristics and subjective impressions of mobile device vibrations.
Endogenous testosterone attenuates neointima formation after moderate coronary balloon injury in male swine.

AIMS Previous studies from our laboratory have demonstrated that testosterone increases coronary smooth muscle protein kinase C delta (PKC delta) both in vivo and in vitro and inhibits coronary smooth muscle proliferation by inducing G(0)/G(1) cell cycle arrest in a PKC delta-dependent manner. The purpose of the present study was to determine whether endogenous testosterone limits coronary neointima (NI) formation in a porcine model of post-angioplasty restenosis. METHODS AND RESULTS Sexually mature, male Yucatan miniature swine were either left intact (IM), castrated (CM), or castrated with testosterone replacement (CMT; Androgel, 10 mg/day). Angioplasty was performed in both the left anterior descending and left circumflex coronary arteries with balloon catheter overinflation to induce either moderate (1.25-1.3 x diameter; 3 x 30 s) or severe (1.4x diameter; 3 x 30 s) injury, and animals were allowed to recover for either 10 or 28 days. Injured coronary sections were dissected, fixed, stained (Verheoff-Van Gieson, Ki67, PKC delta, p27), and analysed. Vessels without internal elastic laminal rupture were excluded. Following moderate injury, intimal area, intima-to-media ratio (I/M), and I/M normalized to rupture index (RI) were increased in CM compared with IM and CMT. RI, medial area, and intimal/medial thickness (IMT) were not different between groups. NI formation was inversely related to serum testosterone concentration. Conversely, following severe injury, there were no significant differences between the groups. Testosterone inhibited proliferation and stimulated PKC delta and p27(kip1) expression during NI formation (10 days post-injury). CONCLUSION These findings demonstrate that endogenous testosterone limits coronary NI formation in male swine and provides support for a protective role for testosterone in coronary vasculoproliferative diseases, such as restenosis and atherosclerosis.
Beyond demand–control: Emotional labour and symptoms of burnout in teachers

Abstract Teaching is a profession that involves a high level of emotional labour. This includes such behaviours as surface acting (displaying an emotion that is not actually felt), deep acting (the activity undertaken to actually feel a required emotion), and suppression of emotion. In many professions, this emotional labour is thought to be related to high levels of burnout. The aim of our study was to show that emotional labour has a unique relationship with burnout that is separate from its relationship with the variables of the Demand Control Support (DCS) model. Emotional labour was studied, together with the variables of the Karasek Job Demand Control Support model, in a random sample of 365 mathematics teachers in the Netherlands. We used the Dutch Questionnaire on Emotional Labor (D-QEL) that measures: (1) surface acting, (2) deep acting, (3) suppression, and (4) emotional consonance. In line with other studies, job characteristics were found to be specifically related to emotional exhaustion. Surface acting was significantly related to depersonalization, and emotional consonance (the absence of emotional labour) was related to personal accomplishment. We conclude that whereas the DCS model has been valuable for understanding emotional exhaustion, emotional labour provides an additional perspective for understanding work stress.
Critical Literacy in Australia: A Matter of Context and Standpoint.

What happens when a ‘radical’ educational idea moves from the political outlands to become a key concept in state curriculum? Postcolonial, feminist and sociological theory of the last two decades proposes a critical educational project as a key step in challenging and transforming dominant discourses and ideologies in postindustrial economies. Yet at the same time there has been heated dialogue at IRA conferences and events about US state and school-board controversies when literacy educators take public stances around issues of the recognition of difference and “social justice” (Young, 1995). What happens when a radical approach to literacy education moves into the tent of a secular state education system? Does it lose its critical edge? Is it a matter of appropriation, repressive tolerance and ‘selling out’? These are the central questions – perhaps obsessions – in this article. This article is an introduction to theories and practices of critical literacy (Muspratt, Luke & Freebody, 1997; Lankshear, 1997; Walton, 1996). It also asks an unresolved question about educational reform in New Times: about the sustainability of a socially-critical, discourse/text based approach to literacy in an conservative educational climate, one characterised not only by moral uncertainty and cultural redefinition, new and renewed forms of economic exclusion and disadvantage, but also by tight-fisted, managerialist responses to diminishing government resources (Apple, 1999; Luke, in press). The unwritten subtitle of this article, then, should probably be something like: Is critical literacy in a state-based educational system an oxymoron? Or: Is that really ‘critical literacy’ or just a watered down version of educational progressivism? Or, for those educational reformers who suddenly find themselves handed the keys to the car: We have we met the enemy and it is us. First, some cautionary advice about the lineage of this article. It is distinctively Australian, a broad outline of the moves to develop critical literacy as an educational project over the past 15 years. Many of us learned a costly lesson from the centre/margin relationships of international educational research: that it is dangerous to generalize any educational approach from one national/regional and cultural context to another. So I’m not proposing the extension of what we’ve done in Australia to other national, regional or local school systems. That is for you to decide, if indeed there are points of convergence and possibility with the cultural practices and textual work of your institutions, and with your normative beliefs about what should count as literacy. A key lesson from the history and sociology of literacy is that literacy education is always a situated response to particular political economies of education (Baker & Luke, 1991). By political economies, I refer to the institutional and governmental arrangements, and the distribution of discourse, material and spatial resources within societies that govern educational reform. In terms of literacy education, we can view our work in state schools as a
Filtering voluntary motion for pathological tremor compensation

This paper describes an algorithm to estimate tremor and voluntary motion from measured motion data. Estimation is performed by means of an extended Kalman filter (EKF), which also estimates tremor parameters. Comparison of the proposed method with techniques described in the literature are conducted with two experimental data sets from tremor patients performing the same task, drawing a spiral. The presented algorithm may be directly applied in real-time pathological tremor compensation systems.
Volumetric abnormalities of the brain in a rat model of recurrent headache

Voxel-based morphometry is used to detect structural brain changes in patients with migraine. However, the relevance of migraine and structural changes is not clear. This study investigated structural brain abnormalities based on voxel-based morphometry using a rat model of recurrent headache. The rat model was established by infusing an inflammatory soup through supradural catheters in conscious male rats. Rats were subgrouped according to the frequency and duration of the inflammatory soup infusion. Tactile sensory testing was conducted prior to infusion of the inflammatory soup or saline. The periorbital tactile thresholds in the high-frequency inflammatory soup stimulation group declined persistently from day 5. Increased white matter volume was observed in the rats three weeks after inflammatory soup stimulation, brainstem in the in the low-frequency inflammatory soup-infusion group and cortex in the high-frequency inflammatory soup-infusion group. After six weeks’ stimulation, rats showed gray matter volume changes. The brain structural abnormalities recovered after the stimulation was stopped in the low-frequency inflammatory soup-infused rats and persisted even after the high-frequency inflammatory soup stimulus stopped. The changes of voxel-based morphometry in migraineurs may be the result of recurrent headache. Cognition, memory, and learning may play an important role in the chronification of migraines. Reducing migraine attacks has the promise of preventing chronicity of migraine.
Impact of intensified testing for urogenital Chlamydia trachomatis infections: a randomised study with 9-year follow-up

Background DNA amplification assays are increasingly being used to facilitate the testing of asymptomatic individuals for urogenital Chlamydia trachomatis. The long-term clinical benefit in terms of avoided infertility and ectopic pregnancy is unknown. Methods In 1997, 15 459 women and 14 980 men aged 21–23 years were living in Aarhus County, Denmark. A random sample of 4000 women and 5000 men was contacted by mail and offered the opportunity to be tested for C trachomatis by means of a sample obtained at home and mailed directly to the laboratory. The remaining 11 459 women and 9980 men received usual care and constituted the control population. All men and women were subsequently followed for 9 years by the use of Danish health registers. Data were collected on pelvic inflammatory disease (PID), ectopic pregnancy (EP), infertility diagnoses, in-vitro fertilisation (IVF) treatment and births in women, and on epididymitis in men. The intervention and control groups were compared using Cox regression analyses and the intention-to-screen principle. Results Among women, no differences were found between the intervention group and the control group: HR (95% CI) for PID 1.12 (0.70 to 1.79); EP 0.97 (0.63 to 1.51); infertility 0.87 (0.71 to 1.07); IVF treatment 0.88 (0.62 to 1.26) and births 1.02 (0.95 to 1.10). In men, the HR for epididymitis was 1.25 (0.70 to 2.24). Conclusions A population-based offer to be tested for urogenital C trachomatis infection by the use of non-invasive samples and DNA amplification did not reduce the long-term risk of reproductive complications in women or of epididymitis in men. Trial registration number in www.clinicaltrials. gov NCT 00827970.
Ontology-based Process Support

This paper describes a principled approach towards creating an IT-support environment for knowledge workers. Starting in the analysis phase our approach paves the way for putting an intelligent assistant to work within a typical business process environment. Thereby, this support intelligence is centred around the interdependencies between documents providing the background knowledge and business processes.
RecentProgress in NumericalMethods forthePoisson- Boltzmann Equation in Biophysical Applications

Efficiency and accuracy are two major concerns in numerical solutions of the Poisson-Boltzmann equation for applications in chemistry and biophysics. Recent developments in boundary element methods, interface methods, adaptive methods, finite element methods, and other approaches for the Poisson-Boltzmann equation as well as related mesh generation techniques are reviewed. We also discussed the chal- lenging problems and possible future work, in particular, for the aim of biophysical applications.
Multimodal functional and morphological nonrigid image registration

The aim of this work is to present the registration of two different and complementary imaging modalities of the human eye fundus. One is a widely used modality consisting of a color photograph of the human retina and the other consists of a functional imaging modality that assesses, in vivo, the human blood-retinal barrier function. The need for the nonrigid registration of these two modalities is demonstrated and is due to the acquisition mode of the functional modality. The two modalities here with registered are from two different devices, have different resolutions and different fields-of-view, i.e., the smaller is only a subset of the larger one. In this paper, all these problems were addressed and a solution proposed.
The Efficacy of Wii-Based Movement Therapy for Upper Limb Rehabilitation in the Chronic Poststroke Period: A Randomized Controlled Trial

Background More effective and efficient rehabilitation is urgently needed to address the prevalence of unmet rehabilitation needs after stroke. This study compared the efficacy of two poststroke upper limb therapy protocols. Aims and/or hypothesis We tested the hypothesis that Wii-based movement therapy would be as effective as modified constraint-induced movement therapy for post-stroke upper-limb motor rehabilitation. Methods Forty-one patients, 2–46 months poststroke, completed a 14-day program of Wii-based Movement Therapy or modified Constraint-induced Movement Therapy in a dose-matched, assessor-blinded randomized controlled trial, conducted in a research institute or patient's homes. Primary outcome measures were the Wolf Motor Function Test timed-tasks and Motor Activity Log Quality of Movement scale. Patients were assessed at prebaseline (14 days pretherapy), baseline, post-therapy, and six-month follow-up. Data were analyzed using linear mixed models and repeated measures analysis of variance. Results There were no differences between groups for either primary outcome at any time point. Motor function was stable between prebaseline and baseline (P > 0·05), improved with therapy (P < 0·001); and improvements were maintained at six-months (P > 0·05). Wolf Motor Function Test timed-tasks log times improved from 2·1 ± 0·22 to 1·7 ± 0·22 s after Wii-based Movement Therapy, and 2·6 ± 0·23 to 2·3 ± 0·24 s after modified Constraint-induced Movement Therapy. Motor Activity Log Quality of Movement scale scores improved from 67·7 ± 6·07 to 102·4 ± 6·48 after Wii-based Movement Therapy and 64·1 ± 7·30 to 93·0 ± 5·95 after modified Constraint-induced Movement Therapy (mean ± standard error of the mean). Patient preference, acceptance, and continued engagement were higher for Wii-based Movement Therapy than modified Constraint-induced Movement Therapy. Conclusions This study demonstrates that Wii-based Movement Therapy is an effective upper limb rehabilitation poststroke with high patient compliance. It is as effective as modified Constraint-induced Movement Therapy for improving more affected upper limb movement and increased independence in activities of daily living.
Family‐based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals

The objective of this study was to determine whether single nucleotide polymorphisms (SNPs) within candidate genes for ADHD are associated with quantitative phenotypes generated from inattentive and hyperactive‐impulsive symptoms. One hundred forty‐three SNPs were genotyped in and around five ADHD candidate genes. A highly heritable quantitative phenotype was generated at each SNP by weighting inattentive and hyperactive‐impulsive symptoms. Once these phenotypes were generated, a screening procedure was used to select and test the five SNP/phenotype combinations with the greatest power to detect an association for each candidate gene. Adjacent SNPs in the promoter region of DRD4, hCV26775267 and hCV26775266, were associated with the quantitative phenotypes generated from the ADHD symptoms (corrected P‐values = 0.012 for both SNPs). The correlations between the ADHD symptoms and quantitative phenotype revealed that inattentive symptoms had a strong influence on the generated phenotype. Subsequent family‐based association test‐principal components (FBAT‐PC) analyses using inattentive symptoms only also had significant associations. SNPs in the promoter region of DRD4 are associated with the phenotypes generated from ADHD symptoms. The strong correlation of the inattentive symptoms with these quantitative phenotypes and the subsequent FBAT‐PC analyses suggest this region is primarily associated with inattentive symptoms. This analysis adds to previous findings by suggesting that variants at these loci may be specifically associated with inattentive symptoms. © 2007 Wiley‐Liss, Inc.