Miracle-dz/UniFAR-FTUs huggingface dataset:
Policy-driven digital infrastructure development in the U.S. healthcare industry : shifting from local to national resistance in new information technology implementation

The increasing capabilities of information technologies (IT) stand to change various types of work. Realizing the transformative potential of IT applications such as artificial intelligence and Big Data analytics relies upon the construction of digital infrastructures capable of capturing, storing, and communicating large amounts of data. In many industries, digital infrastructure development occurs organically as organizations decide to adopt IT that enable access to the infrastructure, with the goal of innovating work processes, collaborating with other organizations, or providing new strategies for evaluating and managing work. Recently, though, government agencies have begun expediting the digital infrastructure creation and growth processes in hopes that infrastructures will enable data-driven innovation, collaboration, and evaluation in public sectors, including education and healthcare. The literature on IT implementations in organizations tells us that the deployment of new IT rarely goes smoothly, particularly when IT use requires substantial changes to everyday practices, existing roles, or established power hierarchies. When workers perceive the effort or threat of IT use to outweigh the benefits of use, they resist the IT in various ways (e.g., by misusing the IT or voicing concerns to managers). Given that digital infrastructure development requires commitment from workers in contributing
Inhibition of Histone Deacetylases in Inflammatory Bowel Diseases

This review, comprised of our own data and that of others, provides a summary overview of histone deacetylase (HDAC) inhibition on intestinal inflammation as well as inflammation-mediated carcinogenesis. Experimental colitis in mice represents an excellent in vivo model to define the specific cell populations and target tissues modulated by inhibitors of HDAC. Oral administration of either suberyolanilide hydroxamic acid (SAHA) or ITF2357 results in an amelioration in these models, as indicated by a significantly reduced colitis disease score and histological score. This effect was paralleled by suppression of proinflammatory cytokines at the site of inflammation as well as specific changes in the composition of cells within the lamina propria. In addition, tumor number and size was significantly reduced in two models of inflammation-driven tumorigenesis, namely interleukin (IL)-10-deficient mice and the azoxymethane-dextran sulfate sodium (DSS) model, respectively. The mechanisms affected by HDAC inhibition, contributing to this antiinflammatory and antiproliferative potency will be discussed in detail. Furthermore, with regard to the relevance in human inflammatory bowel disease, the doses of ITF2357 considered safe in humans and the corresponding serum concentrations are consistent with the efficacious dosing used in our in vivo as well as in vitro experiments. Thus, the data strongly suggest that HDAC inhibitors could serve as a therapeutic option in inflammatory bowel disease.
Development of a remanence measurement-based SQUID system with in-depth resolution for nanoparticle imaging

We present a remanence measurement method using a superconducting quantum interference device (SQUID) to detect trace amounts of magnetic nanoparticles (MNPs). Based on this method, a one-dimensional scanning system was established for imaging. The system was calibrated with 25 nm diameter Fe2O3 nanoparticles (NPs), and the sensitivity of the NPs was found to be 10 ng at a distance of 1.7 cm and the spatial resolution was ∼1 cm. A theoretical model of this system was developed and applied to the deconvolution of scanned images of phantoms with two NP injection spots. Using the developed SQUID system, we were able to determine not only the amount and horizontal positions of the injections, but also their depths in the phantoms.
Amino acids associated with DNA of tumors.

The quantity of amino acids firmly bound to the DNA of a variety of tumors and normal tissues was determined. The DNA from rodent tumors contains 5.4–30 µmoles/100 mg in contrast to 0.8–5.6 in the host tissues. Similar observations were made with human tissues. In a small series of tumors, there were more amino acids in the DNA from the more malignant tumors. There is no correlation between amounts of amino acids and growth rates of tumors, but DNA from regenerating liver has more than that from normal liver. Not only are the total amounts different in tumors, but the relative amounts also differ. Tumor DNA contains less of the basic amino acids. Most striking is the observation that an unusual substance chromatographically similar to the aromatic amino acids appears in a small number of tumors and in normal gastric tissue. This compound is not found in the proteins of these same tissues. It is possible that these amino acid residues are related to function of the DNA.
Rational or Irrational Herding in Online Microloan Markets: Evidence from China

Online peer-to-peer (P2P) lending is a form of online microloan market that enables borrowers to reach individual lenders through online lending platforms rather than through traditional financial institutions such as banks. We investigate the lenders’ rationality via the perspective of herding behavior in this study. Based on the data from PPdai.com, the largest online P2P lending market in China, we found that herding phenomenon is salient in P2P lending market in China, and such herding is dominated by irrationality. Such result is quite different from what obtained based on the data from the Prosper.com in USA. We attribute this difference to the cultural and economical factors.
Position and attitude control of a spherical rolling robot equipped with a gyro

This paper deals with the problem of controlling the position and attitude of a spherical rolling robot. The driving torque for the rolling robot is generated by a new type of mechanism equipped with a gyro. We derive two types of models, a kinematic model and a dynamic model, from the equations of motion for the robot. A feedback controller for the kinematic model is designed by using our previous method that is based on Lyapunov control. And then, from the controller, we obtain a feedback controller for the dynamic model by backstepping technique. The effectiveness of both controllers is demonstrated by numerical simulations
Glial‐derived neurotrophic factor regulates intestinal epithelial barrier function and inflammation and is therapeutic for murine colitis

Although enteric glial cells (EGCs) have been demonstrated to play a key role in maintaining intestinal epithelial barrier integrity, it is not known how EGCs regulate this integrity. We therefore hypothesized that glial‐derived neurotrophic factor (GDNF) produced by EGCs might be involved in this regulation. Here we investigated the role of GDNF in regulating epithelial barrier function in vivo. Recombinant adenoviral vectors encoding GDNF (Ad‐GDNF) were administered intracolonically in experimental colitis induced by dextran sulphate sodium (DSS). The disease activity index (DAI) and histological score were measured. Epithelial permeability was assayed using Evans blue dye. The anti‐apoptotic potency of GDNF in vivo was evaluated. The expression of tumour necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), and myeloperoxidase (MPO) activity were measured by ELISA assay and/or RT‐PCR. The expression of ZO‐1, Akt, caspase‐3, and NF‐κB p65 was analysed by western blot assay. Our results showed that GDNF resulted in a significant reduction in enhanced permeability, inhibited MPO activity, IL‐1β and TNF‐α expression, and increased ZO‐1 and Akt expression. Moreover, GDNF strongly prevented apoptosis in vivo and significantly ameliorated experimental colitis. Our findings indicate that GDNF participates directly in restoring epithelial barrier function in vivo via reduction of increased epithelial permeability and inhibition of mucosal inflammatory response, and is efficacious in DSS‐induced colitis. These findings support the notion that EGCs are able to regulate intestinal epithelial barrier integrity indirectly via their release of GDNF in vivo. GDNF is namely an important mediator of the cross‐talk between EGCs and mucosal epithelial cells. GDNF may be a useful therapeutic approach to the treatment of inflammatory bowel disease. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Osteoblast maturation and new bone formation in response to titanium implant surface features are reduced with age

The surface properties of materials contribute to host cellular response and play a significant role in determining the overall success or failure of an implanted biomaterial. Rough titanium (Ti) surface microtopography and high surface free energy have been shown to enhance osteoblast maturation in vitro and increase bone formation in vivo. Whereas the surface properties of Ti are known to affect osteoblast response, host bone quality also plays a significant role in determining successful osseointegration. One factor affecting host bone quality is patient age. We examined both in vitro and in vivo whether response to Ti surface features was affected by animal age. Calvarial osteoblasts isolated from 1‐, 3‐, and 11‐month‐old rats all displayed a reduction in cell number and increases in alkaline phosphatase–specific activity and osteocalcin in response to increasing Ti surface microtopography and surface energy. Further, osteoblasts from the three ages examined displayed increased production of osteocalcin and local factors osteoprotegerin, vascular endothelial growth factor (VEGF)‐A, and active transforming growth factor (TGF)‐β1 in response to increasing Ti surface roughness and surface energy. Latent TGF‐β1 only increased in cultures of osteoblasts from 1‐ and 3‐month‐old rats. Treatment with the systemic osteotropic hormone 1α,25(OH)2D3 further enhanced the response of osteoblasts to Ti surface features for all three age groups. However, osteoblasts derived from 11‐month‐old animals had a reduced response to 1α,25(OH)2D3 compared to osteoblasts derived from 1‐or 3‐month‐old animals. These results were confirmed in vivo. Ti implants placed in the femoral intramedullary canal of old (9‐month‐old) mice yielded lower bone‐to‐implant contact and neovascularization in response to Ti surface roughness and energy compared to younger (2‐month‐old) mice. These results show that rodent osteoblast maturation in vitro as well as new bone formation in vivo is reduced with age. Whether comparable age differences exist in humans needs to be determined. © 2012 American Society for Bone and Mineral Research.
Sparse channel estimation using adaptive filtering and compressed sampling

This paper discusses the topic of estimating sparse communication channels (i.e. having mostly zero entries) using classical adaptive filtering techniques and the recently-developedmethod of compressed sampling. For this purpose, the Least-Mean Squares (LMS) a variant of it known as 10-LMS are compared with the compressed sampling technique when used to estimate a communication channels having different levels of sparsity.
Antisense transcription of the myotonic dystrophy locus yields low-abundant RNAs with and without (CAG)n repeat

ABSTRACT The unstable (CTG·CAG)n trinucleotide repeat in the myotonic dystrophy type 1 (DM1) locus is bidirectionally transcribed from genes with terminal overlap. By transcription in the sense direction, the DMPK gene produces various alternatively spliced mRNAs with a (CUG)n repeat in their 3′ UTR. Expression in opposite orientation reportedly yields (CAG)n-repeat containing RNA, but both structure and biologic significance of this antisense gene (DM1-AS) are largely unknown. Via a combinatorial approach of computational and experimental analyses of RNA from unaffected individuals and DM1 patients we discovered that DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat. Moreover, its primary transcripts undergo alternative splicing, whereby the (CAG)n segment is removed as part of an intron. Thus, in patients a mixture of DM1-AS RNAs with and without expanded (CAG)n repeat are produced. DM1-AS expression appears upregulated in patients, but transcript abundance remains very low in all tissues analyzed. Our data suggest that DM1-AS transcripts belong to the class of long non-coding RNAs. These and other biologically relevant implications for how (CAG)n-expanded transcripts may contribute to DM1 pathology can now be explored experimentally.
Self-consistent Simulation of self-pulsating two-section gain-coupled DFB lasers

The role of cavity conditions in the dynamics of two-section gain-coupled distributed feedback (DFB) lasers is investigated using a self-consistent model. Self-sustained pulsation (SSP) exists only for devices with strongly coupled DFB gratings. As the coupling strength increases, multiple SSP regimes are developed. The SSP frequency tuning range increases as cavity length decreases. The frequency and modulation index predicted by the model agree well with experimental results. The facet condition of each section is found to affect SSP differently because of the asymmetrical behavior of the modes responsible for SSP.
A Semi-automatic and low-cost method to learn patterns for named entity recognition*

Abstract Named Entity Recognition is a basic task in Information Extraction that aims at identifying entities of interest within full text documents. The patterns used to recognize entities can be rule based, as in the popular JAPE system. However, hand-crafting effective patterns is often difficult, and yet there is little research devoted to methods capable of learning human-readable patterns, possibly with arbitrary sets of features. In this paper, we present a semi-automatic method to generate both regular expressions and a subset of the JAPE language. It does not need a corpus annotated beforehand. Instead, it employs active learning and combines clustering with an algorithm that finds alignments between symbols present in the entities discovered during the learning process. The method currently supports a fixed set of character features and an arbitrary set of token features, but it can incorporate other kinds of features as well. Through several experiments with an English corpus, we show the ability of the method to generate effective patterns at a low annotation cost, and how it can successfully help in the annotation of brand new corpora.
Growth of duck hepatitis virus in chicken embryos and in cell cultures derived from infected embryos.

6. Hofstad, M. S. Antigenic and immunological studies on several isolates of avian infectious bronchitis virus. Avian Diseases 5:102-107. 1961. 7. Hofstad, M. S. , and S. C. Kenzy. Susceptibility of chicks hatched from recovered hens to infectious bronchitis. Cornell Vet. 40:87-89. 1950. 8. Hofstad, M. S. , and H. W. Yoder, Jr. Avian infectious bronchitis virus distribution in tissues of chicks. Avian Diseases 10:230-239. 1966. 9. Jones, R. C. , and F. T. W. Jordan. The exposure of day old chicks to infectious bronchitis and the subsequent development of the oviduct. Vet. Rec. 87:504-506. 1970. 10. Winterfield, R. W. Respiratory signs, immunity response and interference from vaccination with monovalent and multivalent infectious bronchitis vaccines. Avian Diseases 12:577-584. 1968.
Sleep quality and cognitive function in healthy old age: the moderating role of subclinical depression.

OBJECTIVE Previous research has yielded inconclusive results on the relationship between self-reported sleep quality and cognitive performance in healthy old age. Discrepant findings have been reported regarding processing speed and attention, executive functions, and episodic memory. However, sleep quality has also been found to be related to cognitive performance in patients with depression. Our aim was to clarify the relationship between sleep quality and cognitive performance in healthy older adults, and to evaluate the moderating role of subclinical depression on this relationship. METHOD The Pittsburgh Sleep Quality Index was used to assess subjective sleep quality in 107 participants (age ≥ 61 years). A broad battery of neuropsychological tests measured basic cognitive processes, executive functions, and memory processes. RESULTS Subclinical depression moderated the link between sleep quality and cognitive performance. More precisely, poorer sleep quality was associated with lower performance in reasoning, semantic fluency, and shifting in those with high versus low levels of subclinical depression. CONCLUSION Our findings suggest that poor sleep quality might affect higher order cognitive processes, particularly in those reporting higher levels of subclinical depression. Findings on the relationships between sleep quality, cognitive functioning, and depressive symptomatology are discussed in relation to neurobehavioral theories of sleep.
cGMP‐mediated phosphorylation of heat shock protein 20 may cause smooth muscle relaxation without myosin light chain dephosphorylation in swine carotid artery

1 Nitrovasodilators such as nitroglycerine, via production of nitric oxide and an increase in [cGMP], can induce arterial smooth muscle relaxation without proportional reduction in myosin light chain (MLC) phosphorylation or myoplasmic [Ca2+]. These findings suggest that regulatory systems, other than MLC phosphorylation and Ca2+, partially mediate nitroglycerine‐induced relaxation. 2 In swine carotid artery, we found that a membrane‐permeant cGMP analogue induced relaxation without MLC dephosphorylation, suggesting that cGMP mediated the relaxation. 3 Nitroglycerine‐induced relaxation was associated with a reduction in O2 consumption, suggesting that the interaction between phosphorylated myosin and the thin filament was inhibited. 4 Nitroglycerine‐induced relaxation was associated with a 10‐fold increase in the phosphorylation of a protein on Ser16. We identified this protein as heat shock protein 20 (HSP20), a member of a family of proteins known to bind to thin filaments. 5 When homogenates of nitroglycerine‐relaxed tissues were centrifuged at 6000 g, phosphorylated HSP20 preferentially sedimented in the pellet, suggesting that phosphorylation of HSP20 may increase its affinity for the thin filament. 6 We noted that a domain of HSP20 is partially homologous to the ‘minimum inhibitory sequence’ of skeletal troponin I. The peptide HSP20110‐121, which contains this domain, bound to actin‐containing filaments only in the presence of tropomyosin, a characteristic of troponin I. High concentrations of HSP20110‐121 abolished Ca2+‐activated force in skinned swine carotid artery. HSP20110‐121 also partially decreased actin‐activated myosin S1 ATPase activity. 7 These data suggest that cGMP‐mediated phosphorylation of HSP20 on Ser16 may have a role in smooth muscle relaxation without MLC dephosphorylation. HSP20 contains an actin‐binding sequence at amino acid residues 110–121 that inhibited force production in skinned carotid artery. We hypothesize that phosphorylation of HSP20 regulates force independent of MLC phosphorylation via binding of HSP20 to thin filaments and inhibition of cross‐bridge cycling.
Characterization and Regulation of Monocarboxylate Cotransporters Slc16a7 and Slc16a3 in Preimplantation Mouse Embryos1

Abstract Concurrent with compaction, preimplantation mouse embryos switch from the high pyruvate consumption that prevailed during cleavage stages to glucose consumption against a constant background of pyruvate uptake. However, zygotes exposed to and subsequently deprived of glucose can form blastocysts by increasing pyruvate uptake. This metabolic switch requires cleavage-stage exposure to glucose and is one aspect of metabolic differentiation that normally occurs in vivo. Monocarboxylates, such as pyruvate and lactate, are transported across membranes via the SLC16 family of H+-monocarboxylate cotransporter (MCT) proteins. Thus, the increase in pyruvate uptake in embryos developing without glucose must involve changes in activity and localization of MCT. In mouse embryos, continued expression of Slc16a1 (MCT1) requires glucose supply. Messenger RNA for Slc17a7 (MCT2) and Slc16a3 (MCT4) has been detected in mouse preimplantation embryos; however, protein function, localization, and regulation of expression at the basis of these net pyruvate uptake changes remain unclear. The expression and localization of SLC16A7 and SLC16A3 have therefore been examined to clarify their respective roles in embryos derived from the reproductive tract and cultured under varied conditions. SLC16A3 appears localized to the plasma membrane until the morula stage and also maintains a nuclear distribution throughout preimplantation development. However, continued Slc16a3 mRNA expression is dependent on prior exposure to glucose. SLC16A7 localizes to apical cortical regions with punctate, vesicular expression throughout blastomeres, partially colocalizing in peroxisomes with peroxisomal catalase (CAT). In contrast to SLC16A3 and SLC16A1, SLC16A7 and CAT demonstrate upregulation in the absence of glucose. These striking differences between the two isoforms in expression localization and regulation suggest unique roles for each in monocarboxylate transport and pH regulation during preimplantation development, and implicate peroxisomal SLC16A7 as an important redox regulator in the absence of glucose.
A Comment on "Correlation as a Heuristic for Accurate and Comprehensible Ant Colony Optimization-Based Classifiers"

The paper provides a comment from the authors regarding the correlation as a heuristic for accurate and comprehensible ant colony optimization-based classifiers. Baig et al. proposed a new classification rule mining algorithm in IEEE TEC. The technique introduces a correlation-based function for the ant colony optimization (ACO) component. The authors compare variants of the technique with several existing ACO-based algorithms and the state-of-the art RIPPER algorithm. The AntMiner+ algorithm, proposed by Martens et al. (2007) in IEEE TEC, was also included in the comparison. However, the reported performance is far below what is expected and is more akin to making random predictions.
WEB ADMINISTRATION SUGGESTION BY MEANS OF MISUSING AREA AND QOS DATA

Web administrations are incorporated programming segments for the backing of interoperable machine-to-machine association over a system. Web administrations have been broadly utilized for building administration situated applications in both industry and the educated community in late years. The quantity of freely accessible Web administrations is consistently expanding on the Internet. Be that as it may, this multiplication makes it hard for a client to choose an appropriate Web administration among a lot of administration competitors. An improper administration determination may bring about numerous issues (e.g., illsuited execution) to the subsequent applications. In this paper, we propose a novel community separating based Web administration recommender framework to help clients select administrations with ideal Quality-of-Service (QoS) execution. Our recommender framework utilizes the area data and QoS qualities to bunch clients and administrations, and makes customized administration proposal for clients in view of the grouping results. Contrasted and existing administration suggestion techniques, our methodology accomplishes impressive change on the proposal precision. Extensive tests are led including more than 1.5 million QoS records of true Web administrations to exhibit the adequacy of our methodology.