Miracle-dz/UniFAR-FTUs huggingface dataset:
Software and Hardware Cooperate for 1-D FFT Algorithm Optimization on Multicore Processors

Multicore architecture is becoming a promise to keep Moore’s Law and brings a revolution in both research and industry which results new design space for software and architecture. Fast Fourier Transform (FFT), computing intensive and bandwidth intensive, is one of the most popular and important applications in the world. Compared with the computing resource on multicore architecture, the on-chip memory resource is much more expensive because of the limitation of physical chip size. Efficient implementation of FFT algorithm on multicore with good scalability is a challenge for both software and hardware developers. In this paper, supported by the Godson-T architecture, an optimized implementation of 1-D FFT has been developed with matrix transpose conceal and computation/communication overlapping, which achieve more than 30% performance improvement as well as almost 1/3 L2 cache consumption reduce comparing with the base six-step FFT. The limitation of scalability is also analyzed and the conclusion is that on Godson-T when frequency and simultaneous data access happen, the limited access bandwidth of L2 cache is the bottleneck and result in the longer on-chip network latency.
Color texture feature selection by MIFS for image classification

The work presented in this article consists in evaluating the contribution of the use of a texture-color combination in forest mapping. We transform a Spot image into different color spaces, then we extract nine parameters using Laws filter. The resulting set of parameters is reduced using MIFS algorithm based on mutual information. The results are promising and give satisfying classification results.
Estimating perimeter using graph cuts

We investigate the estimation of the perimeter of a set by a graph cut of a random geometric graph. For $\Omega \subset D = (0,1)^d$, with $d \geq 2$, we are given $n$ random i.i. d. points on $D$ whose membership in $\Omega$ is known. We consider the sample as a random geometric graph with connection distance $\varepsilon>0$. We estimate the perimeter of $\Omega$ (relative to $D$) by the, appropriately rescaled, graph cut between the vertices in $\Omega$ and the vertices in $D \backslash \Omega$. We obtain bias and variance estimates on the error, which are optimal in scaling with respect to $n$ and $\varepsilon$. We consider two scaling regimes: the dense (when the average degree of the vertices goes to $\infty$) and the sparse one (when the degree goes to $0$). In the dense regime there is a crossover in the nature of approximation at dimension $d=5$: we show that in low dimensions $d=2,3,4$ one can obtain confidence intervals for the approximation error, while in higher dimensions one can only obtain error estimates for testing the hypothesis that the perimeter is less than a given number.
Investigation of folate-conjugated fluorescent silica nanoparticles for targeting delivery to folate receptor-positive tumors and their internalization mechanism

Multifunctionalized nanoparticles (NPs) are emerging as ideal tools for gene/drug delivery, bioimaging, labeling, or intracellular tracking in biomedical applications, and have attracted considerable attention owing to their unique advantages. In this study, fluorescent silica NPs were synthesized by a modified Stöber method using conjugates of 3-mercaptopropyltrimethoxysilane (MPS) and maleimide-fluorescein isothiocyanate (maleimide-FITC). Mean diameters of the NPs were controlled between 212–2111 nm by regulating MPS concentration in the reaction mixture. Maleimide-FITC molecules were doped into NPs or conjugated to the surface of NPs through the chemical reaction of maleimide and thiol groups. The data showed that the former NPs are better than the latter by comparing their fluorescence intensity. Furthermore, folate molecules were linked to the FITC-doped silica NPs by using polyethylene glycol (PEG) (NH2-PEG-maleimide) as a spacer, thus forming folate receptor targeting fluorescent NPs, referred to as NPs(FITC)-PEG-Folate. The quantitative analysis of cellular internalization into different cancer cells showed that the delivery efficiency of KB cells (folate receptor-positive cells) is more than six-fold higher than that of A549 cells (folate receptor-negative cells). The delivery efficiency of KB cells decreased significantly after free folate addition to the cell culture medium because the folate receptors were occupied by the free folate. The NPs endocytosis mechanism was also investigated. It was shown that clathrin, an inhibitor of cell phagocytosis, markedly decreased the NPs uptake into KB cells, suggesting that it plays an important role in NPs cellular internalization. These results demonstrated that the novel particles of NPs(FITC)-PEG-Folate are promising for fluorescent imaging or targeting delivery to folate receptor-positive tumors.
Effect of 12 Months of Intense Exercise Training on Stroke Volume in Patients with Coronary Artery Disease

The purpose of this study was to determine whether 12 months of intense endurance exercise training can induce an increase in left ventricular stroke volume and in stroke work during exercise in patients with coronary artery disease. Eleven male patients were studied. With training, mean maximal oxygen uptake capacity (Vo2max) increased 39%, from 1.85 ± 0.36 to 2.57 ± 0.43 1/min. Stroke volume during upright exercise that required 35–65% of Vo2max was 18% higher after training. At the same percentage of Vo2max, mean blood pressure was the same before and after training; as a result, left ventricular stroke work (mean blood pressure x stroke volume) increased 18% (p < 0.01). These findings suggest that in patients with coronary artery disease, prolonged, intense training induces an increase in stroke volume, and this is a result of cardiac rather than peripheral adaptations.
Hypermethylation Is Associated with Higher Tumor Stage in Prostate Cancer

Purpose: Zinc is involved in several physiologic processes, including cell growth and proliferation. Although in normal prostate tissue zinc levels are high, there is a marked decrease in prostate cancer. Metallothioneins control the bioavailability of zinc and one isoform, MT1G, was reported down-regulated in prostate cancer. Here, we investigated whether promoter methylation might cause MT1G silencing in prostate cancer. Patients and Methods: The MT1G promoter was assessed by quantitative methylation-specific PCR on prospectively collected tissue samples from 121 patients with prostate cancer, 39 paired high-grade prostatic intraepithelial neoplasias (HGPIN), 29 patients with benign prostatic hyperplasia, 13 normal prostate tissue samples from cystoprostatectomy specimens, and prostate cancer cell lines. The methylation levels were calculated and were correlated with clinical and pathologic variables. Reverse transcription-PCR was done in cell lines to assess MT1G mRNA expression before and after demethylating treatment. Results: MT1G promoter hypermethylation was found in 29 of 121 prostate cancer, 5 of 39 HGPIN, 3 of 29 benign prostatic hyperplasia, and 0 of 13 normal prostate tissue samples. No significant differences in methylation frequencies or levels were found (P = 0.057, for both). Methylation levels were found to correlate with tumor stage but not with Gleason grade. MT1G hypermethylation was more frequent in prostate cancer that spread beyond the prostate capsule. All prostate cancer cell lines tested showed MT1G promoter methylation, but no differences in expression were apparent after demethylation. Conclusions: Our findings suggest that MT1G promoter methylation is associated with tumor aggressiveness in prostate cancer and it might be a marker of locally advanced disease. (Cancer Epidemiol Biomarkers Prev 2005;14(5):1274–8)
Intracellular Free Calcium Concentration During Long Exposures to Simulated Ischemia in Isolated Mammalian Ventricular Muscle

Intracellular free calcium concentration ((Ca2"]1) was measured in isolated ferret ventricular papillary muscles during and after long exposures to ischemia. All experiments were performed at 37°C, and the muscles were stimulated at 1 Hz. Ischemia was simulated by changing from superfusion with oxygenated Tyrode's solution to superfusion with water-saturated gas (95% N2-5% C02), thus simultaneously stopping oxygenation and restricting the extracellular space. [Ca21]1 was measured with aequorin, which was microinjected into superficial cells of the preparation. Exposure to ischemia caused a complex series of changes in [Ca211i. In the first few minutes the changes in [Ca2,11 were variable; however, after approximately 5 minutes all preparations exhibited a progressive increase in amplitude and duration of the stimulated rise in [Ca2]i1 (the calcium transient). The amplitude of the calcium transients peaked after approximately 18 minutes of ischemia, when they were 339% of the control value. After this peak, the calcium transients progressively failed to occur in response to stimulation and declined in amplitude; simultaneously, spontaneous oscillations of [Ca211j appeared and increased in size and frequency. The oscillations in turn then gradually became less frequent until a large, prolonged (5-10 minute) increase in [Ca21]i occurred, after which [Ca2+11 returned to a low level. There were no further oscillations after this event, which was seen on average after 37 minutes of ischemia. A slowly progressive contracture often began to develop at about this time. A gradual rise in resting [Ca2'] occurred during the remainder of the exposure to ischemia. When muscles were reperfused after long exposures to ischemia, there was a very large and prolonged increase in [Ca211i, which was usually associated with a contracture and failure of recovery of developed tension. The large increase in [Ca2]1i could be reduced by the inclusion of 3 mM nickel chloride in the reperfusing solution. Comparison between reperfusion with 02 gas versus reperfusion with anoxic Tyrode's solution indicated that reoxygenation was more beneficial to the muscle than resumption of bulk flow. These results reveal the complex spectrum of changes in [Ca2+11 that occur during ischemia and on reperfusion. These changes in [Ca2]1j are likely to play an important role in the generation of ischemic arrhythmias and muscle damage. (Circulation Research 1992;71:58-69) KEY WoRDs * heart * cardiac muscle * ischemia * intracellular free calcium concentration a
Advanced visual analytics interfaces for adverse drug event detection

Adverse reactions to drugs are a major public health care issue. Currently, the Food and Drug Administration (FDA) publishes quarterly reports that typically contain on the order of 200,000 adverse incidents. In such numerous incidents, low frequency events that are clinically highly significant often remain undetected. In this paper, we introduce a visual analytics system to solve this problem using (1) high scalable interfaces for analyzing correlations between a number of complex variables (e.g., drug and reaction); (2) enhanced statistical computations and interactive relevance filters to quickly identify significant events including those with a low frequency; and (3) a tight integration of expert knowledge for detecting and validating adverse drug events. We applied these techniques to the FDA Adverse Event Reporting System and were able to identify important adverse drug events, such as the known association of the drug Avandia with myocardial infarction and Seroquel with diabetes mellitus, as well as low frequency events such as the association of Boniva with femur fracture. In our evaluation, we found over 90% of the adverse drug events that were published in the Institute for Safe Medication Practices (ISMP) reports from 2009 to 2012. In addition, our domain expert was able to identify some previously unknown adverse drug events.
Development of EHF-band 10W solid-state transmitter

EHF-band will be used in the next generation satellite communication. The transmitter is the major part of RF front-end and the power amplifier is the key component of the transmitter. The design of an EHF-band 10W solid-state transmitter is presented. The transmitter converts signals of Sband to EHF-band and achieves an output power of 10 watts in EHF-band by power combining. The combining efficiency of the EHF-band power amplifier module reaches 80%. The results measured indicate that the transmitter designed has a wide application prospect in the EHF-band satellite communication systems.
Algorithm for facial weight-change [image weight-change simulator]

A facial weight-change simulator is presented. It is intended for use in the evaluation of self-perception distortion of anorexia nervosa (AN) patients. Processing begins with the extraction of the face from the background. Using minimal user intervention, the face is then divided into regions characterized by different weight-change patterns. A mathematical transformation that models growth and shape modification in living organisms is applied to each region. Finally, a unified color face image is generated, in which the face appears fatter or thinner as intended.
Ipriflavone reverses the adverse effects of a low-calcium diet on the histology of the tibia in caged layers

Abstract 1. Ipriflavone (IP) has been widely studied in humans and is effective for inhibiting osteoclastic bone resorption and enhancing osteoblastic bone formation. The aim of this study was to investigate the effects of IP on the structural histology and histomorphometric parameters of tibia in laying hens fed on a low-calcium diet. 2. A total of 200 Hy-Line Brown laying hens, 24 weeks of age, were divided randomly into 4 groups which were fed on one of 4 diets (CaN, standard diet; CaL, low-calcium diet; IP1, low-calcium diet + 8 mg/kg of IP; IP2, low-calcium diet + 20 mg/kg of IP) for 60 d after which 10 hens of each group, chosen at random, were killed and the tibiae were processed and assessed under a fluorescent microscope 3. The cortical bone showing resorption cavities had become porous, and medullary bone did not completely fill the marrow cavity in the CaL group compared with the CaN group. However, in the IP2 group, the cortical bone showed a structure comparable to the CaN group with an absence of resorption cavities, and more medullary bone filled the marrow cavity compared with the CaL group. 4. The CaL hens had significantly lower trabecular bone area, trabecular perimeter, per cent trabecular area, trabecular number and trabecular thickness and significantly wider trabecular separation compared with CaN. These results indicated that the low-calcium diet led to increased loss of tibial bone, eventually causing osteoporosis. However, compared with the CaL group, the IP2 group caused a significant increase in trabecular bone area and bone quality. 5. It is concluded that even in hens fed on a low-calcium diet, the addition of 20 mg/kg IP exerted beneficial effects on histological structure and structural histomorphometric parameters of tibia, indicating an alleviation of caged layer osteoporosis (CLO).
Poisson-Dirichlet Statistics for the extremes of the two-dimensional discrete Gaussian free field

In a previous paper, the authors introduced an approach to prove that the statistics of the extremes of a log-correlated Gaussian field converge to a Poisson-Dirichlet variable at the level of the Gibbs measure at low temperature and under suitable test functions. The method is based on showing that the model admits a one-step replica symmetry breaking in spin glass terminology. This implies Poisson-Dirichlet statistics by general spin glass arguments. In this note, this approach is used to prove Poisson-Dirichlet statistics for the two-dimensional discrete Gaussian free field, where boundary effects demand a more delicate analysis.
Viscous Liquids and the Glass Transition at Extremely High Pressure: Optical Techniques Applied to Cumene in a Diamond Anvil Cell

This dissertation presents the results from experiments studying the pressure-dependence of properties associated with the glass transition in the glass-forming liquid cumene. Through the use of a diamond anvil cell, we achieve extremely high pressures over 40,000 atmospheres. A new technique is refined to directly measure the glass transition temperature Tg extremely accurately, and we show that thermodynamic scaling is capable of describing the liquid glass transition boundary up to record-high pressures. Optical techniques are also implemented to probe the system dynamics in the viscous regime leading up to the glass transition. We present laser light-scattering measurements of the dynamic susceptibility spectra χ ¬¬ ω , obtained under isothermal conditions at 75 ` C, from which we measure the system’s relaxation time as it slows down with increasing pressure. Through a more in-depth analysis, we determine the crossover density ρc predicted by mode coupling theory, and by combining this with previous measurements, the dynamic crossover boundary is mapped up to record-high pressures for any system. Lastly, another isothermal light-scattering experiment probing the longitudinal and transverse acoustic modes is presented, providing an alternative probe to structural relaxation processes. Through the combination of all of these high-pressure techniques on a single glass-forming system, a much greater understanding of viscous liquids and the glass transition is achieved. Furthermore, the development of these techniques represents a major contribution to the field, allowing other researchers to perform similar high-pressure experiments on other systems.
Proficiency of graphene oxide in adsorption and removal of methylene blue from water: An overview

Ever-increasing demands of dye and printing technology has resulted in uncontrolled disposal of dyes into water bodies leading to tremendous environmental pollution. Methylene blue (MB), a popular, water soluble blue dye, has been reported as a major component of water pollutant. It is carcinogenic as well as has enormous toxic effects on the aquatic organisms, thereby considerably affecting ecological food chain. The removal of these types of dyes from water is thus, an important issue and consequently modern technology strongly recommend for less expensive, facile techniques in this regard. Graphene oxide (GO), oxidized form of graphene containing oxygen functionalities, is found to exhibit superior adsorption property compared to available carbon-based materials and therefore possesses significant roles in waste water treatment technology. This overview categorically narrates recent progresses on the fabrication, performances and achievements of GO as adsorbent with a first-hand idea of plausible mechanism of adsorption of MB. A concise outline on the challenges and future prospects of this field has also been highlighted.
Tryptophan to phenylalanine substitutions allow differentiation of short‐ and long‐range conformational changes during denaturation of goat α‐lactalbumin

To test the occurrence of local particularities during the unfolding of Ca2+‐loaded goat α‐lactalbumin (GLA) we replaced Trp60 and ‐118, either one or both, by Phe. In contrast with alternative studies, our recombinant α‐lactalbumins are expressed in Pichia pastoris and do not contain the extra N‐terminal methionine. The substitution of Trp60 leads to a reduction of the global stability. The effect of the Trp118Phe substitution on the conformation and stability of the mutant, however, is negligible. Comparison of the fluorescence spectra of these mutants makes clear that Trp60 and ‐118 are strongly quenched in the native state. They both contribute to the quenching of Trp26 and ‐104 emission. By the interplay of these quenching effects, the fluorescence intensity changes upon thermal unfolding of the mutants behave very differently. This is the reason for a discrepancy of the apparent transition temperatures derived from the shift of the emission maxima (Tm,Fl λ) and those derived from DSC (Tm,DSC). However, the transition temperatures derived from fluorescence intensity (Tm,Fl int) and from DSC (Tm,DSC), respectively, are quite similar, and thus, no local rearrangements are observed upon heat‐induced unfolding. At room temperature, the occurrence of specific local rearrangements upon GdnHCl‐induced denaturation of the different mutants is deduced from the apparent free energies of their transition state obtained from stopped‐flow fluorescence measurements. By ϕ‡‐value analysis it appears that, while the surroundings of Trp118 are exposed in the kinetic transition state, the surroundings of Trp60 remain native. Proteins 2005. © 2005 Wiley‐Liss, Inc.
Orion: RAN Slicing for a Flexible and Cost-Effective Multi-Service Mobile Network Architecture

Emerging 5G mobile networks are envisioned to become multi-service environments, enabling the dynamic deployment of services with a diverse set of performance requirements, accommodating the needs of mobile network operators, verticals and over-the-top (OTT) service providers. Virtualizing the mobile network in a flexible way is of paramount importance for a cost-effective realization of this vision. While virtualization has been extensively studied in the case of the mobile core, virtualizing the radio access network (RAN) is still at its infancy. In this paper, we present Orion, a novel RAN slicing system that enables the dynamic on-the-fly virtualization of base stations, the flexible customization of slices to meet their respective service needs and which can be used in an end-to-end network slicing setting. Orion guarantees the functional and performance isolation of slices, while allowing for the efficient use of RAN resources among them. We present a concrete prototype implementation of Orion for LTE, with experimental results, considering alternative RAN slicing approaches, indicating its efficiency and highlighting its isolation capabilities. We also present an extension to Orion for accommodating the needs of OTT providers.
Integrative Analysis of Metabolic Models – from Structure to Dynamics

The characterization of biological systems with respect to their behavior and functionality based on versatile biochemical interactions is a major challenge. To understand these complex mechanisms at systems level modeling approaches are investigated. Different modeling formalisms allow metabolic models to be analyzed depending on the question to be solved, the biochemical knowledge and the availability of experimental data. Here, we describe a method for an integrative analysis of the structure and dynamics represented by qualitative and quantitative metabolic models. Using various formalisms, the metabolic model is analyzed from different perspectives. Determined structural and dynamic properties are visualized in the context of the metabolic model. Interaction techniques allow the exploration and visual analysis thereby leading to a broader understanding of the behavior and functionality of the underlying biological system. The System Biology Metabolic Model Framework (SBM2 – Framework) implements the developed method and, as an example, is applied for the integrative analysis of the crop plant potato.
Using Tweets to Help Sentence Compression for News Highlights Generation

We explore using relevant tweets of a given news article to help sentence compression for generating compressive news highlights. We extend an unsupervised dependency-tree based sentence compression approach by incorporating tweet information to weight the tree edge in terms of informativeness and syntactic importance. The experimental results on a public corpus that contains both news articles and relevant tweets show that our proposed tweets guided sentence compression method can improve the summarization performance significantly compared to the baseline generic sentence compression method.