Miracle-dz/UniFAR-FTUs huggingface dataset:
What constitutes an effective community pharmacy?--development of a preliminary model of organizational effectiveness through concept mapping with multiple stakeholders.

OBJECTIVE To develop a multi-constituent model of organizational effectiveness for community pharmacy. DESIGN Using Concept Systems software, a project with 14 stakeholders included a three stage process: (i) face to face brainstorming to generate statements describing what constitutes an effective community pharmacy, followed by (ii) statement reduction and approval by participants, followed by (iii) sorting of the statements into themes with rating of each statement for importance. SETTING Primary care in a government-funded, national health care system. PARTICIPANTS A multi-constituent group representing policy-makers and health care providers including; community pharmacy, professional pharmacy organizations, primary health care funders and policy-makers, general practitioners and general practice support organizations. RESULTS Statement clusters included: 'has safe and effective workflows', 'contributes to the safe use of medicines', 'manages human resources and has leadership', 'has a community focus', 'is integrated within primary care', 'is a respected innovator', 'provides health promotion and preventative care', 'communicates and advocates'. These clusters fit into a quadrant model setting stakeholder focus against role development. The poles of stakeholder focus are 'internal capacity' and 'social utility'. The poles of role development are labelled 'traditional safety roles' and 'integration and innovation'. CONCLUSIONS Organizational effectiveness in community pharmacy includes the internal and external focus of the organization and role development. Our preliminary model describes an effective community pharmacy and provides a platform for investigation of the factors that may influence the organizational effectiveness of individual community pharmacies now and into the future.
Gender, Role, and Power: A Content Analysis of Speech

It seems possible that gender differences may often be reducible to differences in role. The authors sought to explore the effects of role and gender on hostile and anxious communications. Role was manipulated through the use of the Melian Dialogues, a technique borrowed from community organization training that asks participants alternately to assume roles of superior and inferior power. Fourteen groups of college students, each with a four-member team of women and a four-member team of men, engaged in the Dialogues. Their communications, recorded and transcribed verbatim, were coded according to the Gottschalk-Gleser method of content analysis. A multivariate analysis of variance revealed that while role had a highly significant effect (p < .0001) on the content of the communications, neither gender nor the order in which roles were assumed exerted a significant influence. Results were interpreted as a consequence of role justification.
Gambling and social gambling: An exploratory study of young people's perceptions and behaviour

Background and aims: Gambling-type games that do not involve the spending of money (e.g., social and ‘demo’ [demonstration] gambling games, gambling-like activities within video games) have been accused in both the legal and psychological literature of increasing minors’ propensity towards prohibited forms of gambling thus prompting calls for gambling regulation to capture address such games and subject them to age restrictions. However, there is still a shortage of empirical data that considers how young people experience monetary and non-monetary gambling, and whether they are sufficiently aware of the differences. Methods: Data was collected from 23 qualitative focus groups carried out with 200 young people aged between 14 and 19 years old in schools based in London and Kent. As the study was exploratory in nature, thematic analysis was adopted in order to capture how pupils categorise, construct, and react to gambling-like activities in comparison to monetary forms of gambling without the constrains of a predetermined theoretical framework. Results: Despite many similarities, substantial differences between monetary and non-monetary forms of gambling were revealed in terms of pupils’ engagement, motivating factors, strengths, intensity, and associated emotions. Pupils made clear differentiation between non-monetary and monetary forms of gambling and no inherent transition of interest from one to the other was observed among participants. Only limited evidence emerged of ‘demo’ games being used as a practice ground for future gambling. Conclusion: For the present sample, non-monetary forms of gambling presented a different proposition to the real-money gambling with no inherent overlap between the two. For some the ‘softer’ form minimised the temptation to try other forms of gambling that they were not legally allowed to engage in, but ‘demo’ games may attract those who already want to gamble. Policy implications: Regulators must recognise and balance these two conflicting aspects.
The relationship between quantity, type, and timing of external childcare and child problem behaviour in Switzerland

This study aimed to investigate the relationship between external childcare and child problem behaviour at age 7 in a culturally diverse urban sample from Switzerland. We used data from the Zurich Project on the Social Development of Children and Youths (z-proso). Findings suggested that the quantity of group-based childcare (but not individual childcare) was related to aggression, ADHD, non-aggressive externalizing behaviour, and anxiety and depression at age 7. Analyses on timing of childcare suggested that the accumulation of childcare over the life course, and not so much childcare in the first years of life, was associated with child problem behaviour. In addition, childcare at age 5 to 7 had a unique relationship with problem behaviour over and above quantity of group-based childcare received in other age periods.
Computational fluid dynamics modeling of intracranial aneurysms: effects of parent artery segmentation on intra-aneurysmal hemodynamics.

PURPOSE The purpose of this study is to show the influence of the upstream parent artery geometry on intraaneurysmal hemodynamics of cerebral aneurysms. METHODS Patient-specific models of 4 cerebral aneurysms (1 posterior communicating artery [PcomA], 2 middle cerebral artery [MCA], and 1 anterior communicating artery [AcomA]) were constructed from 3D rotational angiography images. Two geometric models were constructed for each aneurysm. One model had the native parent vessel geometry; the second model was truncated approximately 1 cm upstream from the aneurysm, and the parent artery replaced with a straight cylinder. Corresponding finite element grids were generated and computational fluid dynamics simulations were carried out under pulsatile flow conditions. The intra-aneurysmal flow patterns and wall shear stress (WSS) distributions were visualized and compared. RESULTS Models using the truncated parent vessel underestimated the WSS in the aneurysms in all cases and shifted the impaction zone to the neck compared with the native geometry. These effects were more pronounced in the PcomA and AcomA aneurysms where upstream curvature was substantial. The MCA aneurysm with a long M1 segment was the least effected. The more laminar flow pattern within the parent vessel in truncated models resulted in a less complex intra-aneurysmal flow patterns with fewer vortices and less velocity at the dome. CONCLUSIONS Failure to properly model the inflow stream contributed by the upstream parent artery can significantly influence the results of intra-aneurysmal hemodynamic models. The upstream portion of the parent vessel of cerebral aneurysms should be included to accurately represent the intra-aneurysmal hemodynamics.
Homocysteine lowering and cardiovascular events after acute myocardial infarction.

BACKGROUND Homocysteine is a risk factor for cardiovascular disease. We evaluated the efficacy of homocysteine-lowering treatment with B vitamins for secondary prevention in patients who had had an acute myocardial infarction. METHODS The trial included 3749 men and women who had had an acute myocardial infarction within seven days before randomization. Patients were randomly assigned, in a two-by-two factorial design, to receive one of the following four daily treatments: 0.8 mg of folic acid, 0.4 mg of vitamin B12, and 40 mg of vitamin B6; 0.8 mg of folic acid and 0.4 mg of vitamin B12; 40 mg of vitamin B6; or placebo. The primary end point during a median follow-up of 40 months was a composite of recurrent myocardial infarction, stroke, and sudden death attributed to coronary artery disease. RESULTS The mean total homocysteine level was lowered by 27 percent among patients given folic acid plus vitamin B12, but such treatment had no significant effect on the primary end point (risk ratio, 1.08; 95 percent confidence interval, 0.93 to 1.25; P=0.31). Also, treatment with vitamin B6 was not associated with any significant benefit with regard to the primary end point (relative risk of the primary end point, 1.14; 95 percent confidence interval, 0.98 to 1.32; P=0.09). In the group given folic acid, vitamin B12, and vitamin B6, there was a trend toward an increased risk (relative risk, 1.22; 95 percent confidence interval, 1.00 to 1.50; P=0.05). CONCLUSIONS Treatment with B vitamins did not lower the risk of recurrent cardiovascular disease after acute myocardial infarction. A harmful effect from combined B vitamin treatment was suggested. Such treatment should therefore not be recommended. (ClinicalTrials.gov number, NCT00266487.).
Domain Independent Event Analysis for Log Data Reduction

Analyzing the run time behavior of large software systems is a difficult and challenging task. Log analysis has been proposed as a possible solution. However, such an analysis poses unique challenges, mostly due to the volume and diversity of the logged data that is collected, thus making this analysis often intractable for practical purposes. In this paper, we present a log analysis technique that aims to compute a smaller, compared to the original, collection of events that relate to a given analysis objective. The technique is based on computing a similarity score between the logged events and a collection of significant events that we refer to as beacons. The major novelties of the proposed technique are that it is domain independent and that it does not require the use of a pre-existing training data set. The technique has been evaluated against the DARPA Intrusion Detection Evaluation 1999 and the KDD 1999 data sets with promising results.
Leader, president, person: Lexical ambiguities and interpretive implications

This article discusses the possible ambiguities that exist between three different words: personalization, presidentialization and leader. In recent times, and mostly in Europe, the first two words have been used very frequently by media scholars and political scientists to point out changes taking place both in the decision-making process and in the public arena. At the same time, the older word, leader, is still alive and very much used. Do these words, and the processes they involve, have the same meaning? Do they refer to different changes? Are they used without the sufficient cognitive awareness? The article proposes three dimensions that may be useful to understand similarities and differences in the use of these three words.
Quantum Thermodynamics: A Dynamical Viewpoint

Quantum thermodynamics addresses the emergence of thermodynamic laws from quantum mechanics. The viewpoint advocated is based on the intimate connection of quantum thermodynamics with the theory of open quantum systems. Quantum mechanics inserts dynamics into thermodynamics, giving a sound foundation to finite-time-thermodynamics. The emergence of the 0-law, I-law, II-law and III-law of thermodynamics from quantum considerations is presented. The emphasis is on consistency between the two theories, which address the same subject from different foundations. We claim that inconsistency is the result of faulty analysis, pointing to flaws in approximations.
Microgadgets: Size Does Matter in Turing-Complete Return-Oriented Programming

Return-oriented programming (ROP) has gained a lot of popularity lately, as an attack against currently implemented defenses in modern operating systems. Several kinds of ROP-based attacks and anti-ROP defenses have been proposed in recent years. The original attack technique depends on the existence of a hand-picked set of byte sequences (called gadgets) in the program, while subsequent approaches use complex scanners, which perform semantic analysis on the code to locate gadgets. The latter ones are efficient at finding gadgets and building an attack, but incur a significant cost in time. We propose a ROP attack technique, based on a handpicked but flexible and Turing-complete set of gadgets. One novelty in this approach is the use of microgadgets, which are gadgets restricted to 2 or 3 bytes in length. Our approach splits gadgets into several classes of varying sizes (from 1 to more than 800). Only a single gadget from each class is required for Turing-completeness. The short length of the gadgets, as well as the large size of the classes, increase the likelihood of finding all required gadgets. We also describe an efficient scanner which locates these gadgets in a given program. We then use this scanner on the /usr/bin directories from several Linux distributions, to show that many programs indeed contain a Turing-complete set of microgadgets, which attackers can use to perform arbitrary computations.
High Precision SC Cavity Diagnostics with HOM Measurements

Experiments at the FLASH linac at DESY have demonstrated that the Higher Order Modes induced in Superconducting Cavities can be used to provide a variety of beam and cavity diagnostics. The centers of the cavities can be determined from the beam orbit which produces minimum power in the dipole HOM modes. The phase and amplitude of the dipole modes can be used as a high resolution beam position monitor, and the phase of the monopole modes to measure the beam phase relative to the accelerator RF. Beam orbit feedback which minimizes the dipole HOM power in a set of structures has been demonstrated. For most SC accelerators, the existing HOM couplers provide the necessary signals, and the downmix and digitizing electronics are straightforward, similar to those for a conventional BPM.
Scalable Inference for Latent Dirichlet Allocation

We investigate the problem of learning a topic model - the well-known Latent Dirichlet Allocation - in a distributed manner, using a cluster of C processors and dividing the corpus to be learned equally among them. We propose a simple approximated method that can be tuned, trading speed for accuracy according to the task at hand. Our approach is asynchronous, and therefore suitable for clusters of heterogenous machines.
Do background images improve "draw a secret" graphical passwords?

Draw a secret (DAS) is a representative graphical password scheme. Rigorous theoretical analysis suggests that DAS supports an overall password space larger than that of the ubiquitous textual password scheme. However, recent research suggests that DAS users tend to choose weak passwords, and their choices would render this theoretically sound scheme less secure in real life. In this paper we investigate the novel idea of introducing background images to the DAS scheme, where users were initially supposed to draw passwords on a blank canvas overlaid with a grid. Encouraging results from our two user studies have shown that people aided with background images tended to set significantly more complicated passwords than their counterparts using the original scheme. The background images also reduced other predictable characteristics in DAS passwords such as symmetry and centering within the drawing grid, further improving the strength of the passwords. We estimate that the average strength of successfully recalled passwords in the enhanced scheme was increased over those created using the original scheme by more than 10 bits. Moreover, a positive effect was observed with respect to the memorability of the more complex passwords encouraged by the background images.
Particle agglutination assays for rapid detection of fibronectin, fibrinogen, and collagen receptors on Staphylococcus aureus

Latex beads (0.8-micron diameter; Difco Laboratories) were coated with fibronectin, fibrinogen, collagen type I, or denatured collagen (gelatin) and evaluated in a particle agglutination assay (PAA) for the rapid detection of fibronectin, fibrinogen, or collagen binding to Staphylococcus aureus. These assays were compared with a commercial test for detecting the binding of fibrinogen and immunoglobulin G (Staphaurex). Bacterial cells (approximately 10(10) cells per ml) suspended in 0.02 M potassium phosphate buffer (pH 6.8) caused the clumping of standard fibronectin, collagen, gelatin, and fibrinogen latex suspensions within 2 min on glass slides. The test results were scored semiquantitatively from strongly positive ( ) to weakly positive (+) and negative (-) reactions. The negative PAA reactions corresponded to a median value of 11.5% relative to the binding of 125I-labeled protein to strain Cowan 1, indicating the high sensitivity of the test. The reactions with fibronectin and fibrinogen latex suspensions and with Staphaurex were optimal for cells grown on tryptic soy and brain heart infusion broth media. Blood agar was optimal for reactions with collagen and gelatin latex suspensions. Media containing high salts (mannitol salt agar and staphylococcus medium 110) enhanced the tendency of cells to autoaggregate. These assays were also clinically evaluated on 187 S. aureus isolates. The PAA reagents were stable, and the assays were highly specific, sensitive, and reproducible, thus making PAA suitable for the rapid screening of the binding of various bacterial pathogens to serum and connective-tissue proteins.
Jointly modeling the relationship between longitudinal and survival data subject to left truncation with applications to cystic fibrosis

Numerous methods for joint analysis of longitudinal measures of a continuous outcome y and a time to event outcome T have recently been developed either to focus on the longitudinal data y while correcting for nonignorable dropout, to predict the survival outcome T using the longitudinal data y, or to examine the relationship between y and T. The motivating problem for our work is in joint modeling of the serial measurements of pulmonary function (FEV1% predicted) and survival in cystic fibrosis (CF) patients using registry data. Within the CF registry data, an additional complexity is that not all patients have been followed from birth; therefore, some patients have delayed entry into the study while others may have been missed completely, giving rise to a left truncated distribution. This paper shows in joint modeling situations where y and T are not independent, that it is necessary to account for this left truncation to obtain valid parameter estimates related to both survival and the longitudinal marker. We assume a linear random effects model for FEV1% predicted, where the random intercept and slope of FEV1% predicted, along with a specified transformation of the age at death follow a trivariate normal distribution. We develop an expectation‐maximization algorithm for maximum likelihood estimation of parameters, which takes left truncation and right censoring of survival times into account. The methods are illustrated using simulation studies and using data from CF patients in a registry followed at Rainbow Babies and Children's Hospital, Cleveland, OH. Copyright © 2012 John Wiley & Sons, Ltd.
Regulation of miR394 in Response to Fusarium oxysporum f. sp. cepae (FOC) Infection in Garlic (Allium sativum L)

MicroRNAs (miRNAs) are a class of post-transcriptional regulators that negatively regulate gene expression through target mRNA cleavage or translational inhibition and play important roles in plant development and stress response. In the present study, six conserved miRNAs from garlic (Allium sativum L.) were analyzed to identify differentially expressed miRNAs in response to Fusarium oxysporum f. sp. cepae (FOC) infection. Stem-loop RT-PCR revealed that miR394 is significantly induced in garlic seedlings post-treatment with FOC for 72 h. The induction of miR394 expression during FOC infection was restricted to the basal stem plate tissue, the primary site of infection. Garlic miR394 was also upregulated by exogenous application of jasmonic acid. Two putative targets of miR394 encoding F-box domain and cytochrome P450 (CYP450) family proteins were predicted and verified using 5′ RLM-RACE (RNA ligase mediated rapid amplification of cDNA ends) assay. Quantitative RT-PCR showed that the transcript levels of the predicted targets were significantly reduced in garlic plants exposed to FOC. When garlic cultivars with variable sensitivity to FOC were exposed to the pathogen, an upregulation of miR394 and down regulation of the targets were observed in both varieties. However, the expression pattern was delayed in the resistant genotypes. These results suggest that miR394 functions in negative modulation of FOC resistance and the difference in timing and levels of expression in variable genotypes could be examined as markers for selection of FOC resistant garlic cultivars.
Cerebellar representation of the eyeblink response as revealed by PET

&NA; Blink reflex‐related areas in the human cerebellum were studied using [15O]H2O PET in eight healthy subjects. Eyeblinks were evoked by airpuff stimulation and recorded via surface electrodes. PET analysis revealed a cerebellar increase of regional cerebral blood flow in vermal lobule VI and a small ipsilateral paravermal extension in the eyeblink condition compared to rest. This activation partly overlapped with areas found in recent fMRI and animal studies investigating the cerebellar involvement in control of the unconditioned and acquisition of the conditioned eyeblink response. In conclusion, vermal lobule VI extending to ipsilateral paravermal areas appears to be involved in control of the unconditioned eyeblink response. NeuroReport 14:1371–1374 © 2003 Lippincott Williams & Wilkins.
Implicit Theories of Creativity Across Cultures

One potential problem for creativity theory is whether both novelty and appropriateness are equally valid dimensions across cultures. Taking an implicit theory approach, the authors surveyed more than 400 students from Japan, China, and the United States. Using repeated measures scenarios of cooking and textbook products, novelty was found to be important across the three countries for evaluations of creativity. However, the Chinese were more swayed than were the Americans by the novelty manipulation in terms of how much they desired the products. Appropriateness was more important for Americans and Japanese for evaluations of creativity and desire for products. Both novelty and appropriateness had large effects. Rather than relying on assumed country variations, the authors argue that cross-cultural research be used to understand the nature of creativity.