Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrated insulin pump therapy with continuous glucose monitoring for improved adherence: technology update

Insulin pump therapy combined with real-time continuous glucose monitoring, known as sensor-augmented pump (SAP) therapy, has been shown to improve metabolic control and to reduce the rate of hypoglycemia in adults with type 1 diabetes compared to multiple daily injections or standard continuous subcutaneous insulin infusion. Glycemic variability is also reduced in patients on SAP therapy. This approach allows patients to monitor their glucose levels being informed of glycemic concentration and trend. Trained diabetic patients, therefore, can appropriately modify insulin infusion and/or carbohydrate intake in order to prevent hypo- or hyperglycemia. For these reasons, SAP therapy is now considered the gold standard for type 1 diabetes treatment. To be clinically effective, however, devices and techniques using advanced technology should not only have the potential to theoretically ameliorate metabolic control, but also be well accepted by patients in terms of satisfaction and health-related quality of life, because these factors will improve treatment adherence and consequently overall outcome. SAP therapy is generally well tolerated by patients; however, many clinical trials have identified significant noncompliance in the use of this device, most notably in the pediatric and adolescent populations. In this review we aim to analyze the main reasons for good or poor adherence to SAP therapy and to provide useful tips in order to fully benefit from this kind of novel therapeutic approach.
The Price of Uncertainty: Chance-Constrained OPF vs. in-Hindsight OPF

The operation of power systems has become more challenging due to feed-in of volatile renewable energy sources. Chance-constrained optimal power flow (CCOPF) is one possibility to explicitly consider volatility via probabilistic uncertainties resulting in mean-optimal feedback policies. These policies are computed before knowledge of the realization of the uncertainty is available. On the other hand, the hypothetical case of computing the power injections knowing every realization beforehand-called in-hindsight OPF (hoPF)-cannot be outperformed w.r. t. costs and constraint satisfaction. In this paper, we investigate how ccOPF feedback relates to the full-information hOPF. To this end, we introduce different dimensions of the price of uncertainty. Using mild assumptions on the uncertainty we present sufficient conditions when ccOPF is identical to hOPF. We suggest using the total variational distance of probability densities to quantify the performance gap of hO PF and ccOPF. Finally, we draw upon a tutorial example to illustrate our results.
A Polyketide Synthase Acyltransferase Domain Structure Suggests a Recognition Mechanism for Its Hydroxymalonyl-Acyl Carrier Protein Substrate

We have previously shown that the acyl transferase domain of ZmaA (ZmaA-AT) is involved in the biosynthesis of the aminopolyol polyketide/nonribosomal peptide hybrid molecule zwittermicin A from cereus UW85, and that it specifically recognizes the precursor hydroxymalonyl-acyl carrier protein (ACP) and transfers the hydroxymalonyl extender unit to a downstream second ACP via a transacylated AT domain intermediate. We now present the X-ray crystal structure of ZmaA-AT at a resolution of 1.7 Å. The structure shows a patch of solvent-exposed hydrophobic residues in the area where the AT is proposed to interact with the precursor ACP. We addressed the significance of the AT/ACP interaction in precursor specificity of the AT by testing whether malonyl- or methylmalonyl-ACP can be recognized by ZmaA-AT. We found that the ACP itself biases extender unit selection. Until now, structural information for ATs has been limited to ATs specific for the CoA-linked precursors malonyl-CoA and (2S)-methylmalonyl-CoA. This work contributes to polyketide synthase engineering efforts by expanding our knowledge of AT/substrate interactions with the structure of an AT domain that recognizes an ACP-linked substrate, the rare hydroxymalonate. Our structure suggests a model in which ACP interaction with a hydrophobic motif promotes secondary structure formation at the binding site, and opening of the adjacent substrate pocket lid to allow extender unit binding in the AT active site.
SENSdesc: Connect Sensor Queries and Context

Modern developments confront us with an ever increasing amount of streaming data: different sensors in environments like hospitals or factories communicate their measurements to other applications. Having this data at disposal faces us with a new challenge: the data needs to be integrated to existing frameworks. As the availability of sensors can rapidly change, these need to be flexible enough to easily incorporate new systems without having to be explicitly configured. Semantic Web applications offer a solution for that enabling computers to ‘understand’ data. But for them the pure amount of data and different possible queries which can be performed on it can form an obstacle. This paper tackles this problem: we present a formalism to describe stream queries in the ontology context in which they might become relevant. These descriptions enable us to automatically decide based on the actual setting and the problem to be solved which and how sensors should be monitored further. This helps us to limit the streaming data taken into account for reasoning tasks and make stream reasoning more performant. We illustrate our approach on a health-care use case where different sensors are used to measure data on patients and their surrounding in a hospital.
Strength Aspects of Glass Fibre Reinforced Concrete

Glass Fibre Reinforced concrete (GFRC) is a recent introduction in the field of concrete technology. It has been extensively used in over 100 countries since its introduction in 1980ÂÂs. This product is covered by international standards and has been practiced all over the world. GFRC has advantage of being light weight and thereby reducing the overall cost of construction there by bringing economy in construction. This work is only an accumulation of information about GFRC from all over the internet and some text books. GFRC is concrete that uses glass fibres for reinforcement instead of steel. It is typically cast in a thin section of around ½ÂÂ to ¾ÂÂ. Since the fibres cannot rust like steel, there is no need for a protective concrete cover thickness to prevent rusting. With the thin, hollow construction of GFRC products, they can weigh a fraction of weight of traditional precast concrete.
Experiences of women who reported sexual assault at a provincial hospital, South Africa

Background Sexual assault poses a serious health problem to both the survivor and the health system. Experiencing sexual assault requires women to seek medical and psychological assistance as part of their journey towards recovery. This study examined the experiences of women who received post-sexual assault services from a specialised care centre within a provincial hospital. Methods A qualitative, exploratory and contextual design was used to explore and describe experiences of women. Data were obtained through individual in-depth interviews from a total of 18 women aged between 18 and 55 years. Interviews were supplemented by the researcher’s field notes and audiotape recordings. Results Findings yielded two main themes: Women expressed their lived experiences of sexual assault characterised by different forms of trauma. The second theme was an expression of a need for safety and support. Conclusion Women who experience sexual assault are left with devastating effects such as physical and psychological harm and social victimisation. There is also a need for safety and support towards the recovery of these women. This study recommends that professional practitioners involved in the management of sexual assault be sensitised regarding the ordeal experienced by women and stop perceiving survivors as crime scene ‘clients’ from whom only medico-legal evidence has to be collected. Professional practitioners and family members must be supportive, non-judgemental and considerate of the dignity of survivors. The establishment of sexual assault response teams (SART) is also recommended. There should also be inter-professional education for better coordination of services rendered to sexually assaulted women.
Eating Patterns and Health Outcomes in Patients With Type 2 Diabetes

Purpose: To evaluate the relationship between eating patterns and therapeutic target’s achieving in patients with type 2 diabetes. Methods: In this cross-sectional study, patients underwent clinical, laboratory, and nutritional evaluations. Dietary intake was assessed by a quantitative food frequency questionnaire and eating patterns identified by cluster analysis. The therapeutic targets were as follows: blood pressure, <140/90 mm Hg; BMI, <25 kg/m2 (<27 kg/m2 for elderly); waist circumference, <94 cm for men and <80 cm for women; fasting plasma glucose, <130 mg/dL; HbA1c, <7%; triglycerides, <150 mg/dL; HDL-cholesterol, >40 mg/dL for men and >50 mg/dL for women; LDL-cholesterol, <100 mg/dL. Results: One hundred ninety seven patients were studied. We identified two eating patterns: “unhealthy” (n = 100)—high consumption of refined carbohydrates, ultra-processed foods, sweets and desserts (P < 0.05); and “healthy” (n = 97)—high intake of whole carbohydrates, dairy, white meat, fish, fruits and vegetables (P < 0.05). The healthy group more frequently achieved therapeutic targets for fasting plasma glucose, HbA1c, and LDL-cholesterol than the unhealthy group. Poisson regression confirmed the association of healthy eating pattern with attaining the therapeutic target for fasting plasma glucose [PR, 1.59 (95% CI, 1.01 to 2.34); P = 0.018], HbA1c [PR, 2.09 (95% CI, 1.17 to 3.74); P = 0.013], and LDL-cholesterol [PR, 1.37 (95% CI, 1.01 to 1.86); P = 0.042]. Conclusions: A healthy eating pattern, including the frequent intake of whole carbohydrates, dairy, white meat, fish, fruits, and vegetables, is associated with reduced fasting plasma glucose, HbA1c, and LDL cholesterol levels in patients with type 2 diabetes.
Development of non-destructive inspection technology of titanium

This paper describes the recent technological advances on the nondestructive testing (NDT) of titanium products, which was surveyed through the activities of the Japan Titanium Society. Titanium tubes are tested by ultrasonic testing (UT), eddy current testing (ET) or leakage testing (LT) based on JIS or ASTM standards, whereas titanium sheets, rods or wires are tested according to the requirements of customers or the specifications of manufacturers themselves, because no standards are available. Titanium sheets are tested by UT or liquid penetrant testing (PT). Titanium rods and wires are tested by UT, PT or ET.
Addiction to work and factors relating to this: a cross-sectional study on doctors in the state of Paraíba

ABSTRACT CONTEXT AND OBJECTIVE: Addiction to work is one of the new behavioral phenomena present in organizations and it is characterized by excess work and compulsion to work. This phenomenon may give rise to different sicknesses and may affect different professionals, including doctors. Thus, the aims of this study were to analyze the factorial validity and internal consistency of the Dutch Work Addiction Scale (DUWAS); to evaluate the prevalence of addiction to work among doctors in the state of Paraíba; and to investigate factors relating to addiction to work among these doctors. DESIGN AND SETTING: This was an exploratory, descriptive cross-sectional study with a quantitative approach conducted in municipalities in the state of Paraíba. METHODS: Data were gathered between June and October 2015, by applying a questionnaire containing sociodemographic questions and the Work Addiction Scale. RESULTS: The results showed that the Work Addiction Scale has internal consistency and factorial validity and that, in the population studied, only one factor was pointed out: addiction to work. Most of the doctors were not addicted to work; among the addicts, the addiction was not excessive; and the addiction had a positive correlation with the number of shifts done and a negative correlation with age. CONCLUSION: Greater attention to this phenomenon is required and further research on this topic is needed in order to elucidate the harm caused by addiction to work in daily medical practice.
Nitrogen‐Functionalized Hydrothermal Carbon Materials by Using Urotropine as the Nitrogen Precursor

Abstract Nitrogen‐containing hydrothermal carbon (N‐HTC) materials of spherical particle morphology were prepared by means of hydrothermal synthesis with glucose and urotropine as precursors. The molar ratio of glucose to urotropine has been varied to achieve a continuous increase in nitrogen content. By raising the ratio of urotropine to glucose, a maximal nitrogen fraction of about 19 wt % could be obtained. Decomposition products of both glucose and urotropine react with each other; this opens up a variety of possible reaction pathways. The pH has a pronounced effect on the reaction pathway of the corresponding reaction steps. For the first time, a comprehensive analytical investigation, comprising a multitude of analytical tools and instruments, of a series of nitrogen‐containing HTC materials was applied. Functional groups and structural motifs identified were analyzed by means of FTIR spectroscopy, thermogravimetric MS, and solid‐state NMR spectroscopy. Information on reaction mechanisms and structural details were obtained by electronic structure calculations that were compared with vibrational spectra of polyfuran or polypyrrole‐like groups, which represent structural motifs occurring in the present samples.
Psychoacoustic analysis of preference reverberation time for Gamelan Bali Concert Hall

Lately, there has been increasing interest to design acoustic concert hall for Indonesia traditional music, for example Gamelan Bali. In order to obtain a good and comprehensive design, some research on acoustical properties of Gamelan itself must be conducted. One of the main concerns was to find the optimum value of reverberation time for Gamelan music. Unlike the orchestra and classical music performance, preference value of reverberation time for Gamelan Bali is not known yet. Psychoacoustic research was conducted to obtain the preference of reverberation time for Gamelan Bali. A number of respondents were included in the experiment to give the subjective ratings. The subjects were divided into three groups based on their knowledge and experience of Gamelan Bali music. The results suggest that group which is accustomed to Gamelan music produced more significant results in their subjective ratings than the other groups. Based on that results, the preference value of Gamelan reverberation time was concluded.
Obesity is a significant susceptibility factor for idiopathic AA amyloidosis

Abstract Background: To investigate obesity as susceptibility factor in patients with idiopathic AA amyloidosis. Methods: Clinical, biochemical and genetic data were obtained from 146 patients with AA amyloidosis. Control groups comprised 40 patients with long-standing inflammatory diseases without AA amyloidosis and 56 controls without any inflammatory disease. Findings: Patients with AA amyloidosis had either familial Mediterranean fever (FMF) or long-standing rheumatic diseases as underlying inflammatory disease (n = 111, median age 46 years). However, in a significant proportion of patients with AA amyloidosis no primary disease was identified (idiopathic AA; n = 37, median age 60 years). Patients with idiopathic AA amyloidosis were more obese and older than patients with AA amyloidosis secondary to FMF or rheumatic diseases. Serum leptin levels correlated with the body mass index (BMI) in all types of AA amyloidosis. Elevated leptin levels of more than 30 µg/l were detected in 18% of FMF/rheumatic + AA amyloidosis and in 40% of patients with idiopathic AA amyloidosis (p = .018). Finally, the SAA1 polymorphism was confirmed as a susceptibility factor for AA amyloidosis irrespective of the type of the disease. Conclusions: Obesity, age and the SAA1 polymorphism are susceptibility factors for idiopathic AA amyloidosis. Recent advances in treatment of FMF and rheumatic disorders will decrease the incidence of AA amyloidosis due to these diseases. Idiopathic AA, however, might be an emerging problem in the ageing and increasingly obese population.
A Mixed-Membership Model for Social Network Clustering

We propose a simple mixed membership model for social network clustering in this paper. A flexible function is adopted to measure affinities among a set of entities in a social network. The model not only allows each entity in the network to possess more than one membership, but also provides accurate statistical inference about network structure. We estimate the membership parameters using an MCMC algorithm. We evaluate the performance of the proposed algorithm by applying our model to two empirical social network data, the Zachary club data and the bottlenose dolphin network data. We also conduct some numerical studies based on synthetic networks for further assessing the effectiveness of our algorithm. In the end, some concluding remarks and future work are addressed briefly.
C and OpenCL generation from MATLAB

In many engineering and science areas, models are developed and validated using high-level programing languages and environments as is the case with MATLAB. In order to target the multicore heterogeneous architectures being used on embedded systems to provide high performance computing with acceptable energy/power envelops, developers manually migrate critical code sections to lower-level languages such as C and OpenCL, a time consuming and error prone process. Thus, automatic source-to-source approaches are highly desirable. We present an approach to compile MATLAB and output equivalent C/OpenCL code to target architectures, such as GPU based hardware accelerators. We evaluate our approach on an existing MATLAB compiler framework named MATISSE. The OpenCL generation relies on the manual insertion of directives to guide the compilation and is also capable of generating C wrapper code to interface and synchronize with the OpenCL code. We evaluated the compiler with a number of benchmarks from different domains and the results are very encouraging.
Sensing the Chinese Diaspora: How Mobile Apps Can Provide Insights Into Global Migration Flows

Many countries today have "country-centric mobile apps" which are mobile apps that are primarily used by residents of a specific country. Many of these country-centric apps also include a location-based service which takes advantage of the smartphone's API access to the smartphone's current GPS location. In this paper, we investigate how such country-centric apps with location-based services can be employed to study the diaspora associated with ethnic and cultural groups. Our methodology combines GPS hacking, automated task tools for mobile phones, and OCR to generate migration statistics for diaspora. As a case study, we apply our methodology to WeChat, an enormously popular app within China and among ethnic Chinese worldwide. Using WeChat, we collect data about the Chinese diaspora in 32 cities. The combined data provides interesting insights to the modern Chinese diaspora and how it has changed in recent years.
Interaction of Norepinephrine and Glucocorticoids Modulate Inhibition of Principle Cells of Layer II Medial Entorhinal Cortex in Male Mice

Spatial memory processing requires functional interaction between the hippocampus and the medial entorhinal cortex (MEC). The grid cells of the MEC are most abundant in layer II and rely on a complex network of local inhibitory interneurons to generate spatial firing properties. Stress can cause spatial memory deficits in males, but the specific underlying mechanisms affecting the known memory pathways remain unclear. Stress activates both the autonomic nervous system and the hypothalamic-pituitary-adrenal axis to release norepinephrine (NE) and glucocorticoids, respectively. Given that adrenergic receptor (AR) and glucocorticoid receptor (GR) expression is abundant in the MEC, both glucocorticoids and NE released in response to stress may have rapid effects on MEC-LII networks. We used whole-cell patch clamp electrophysiology in MEC slice preparations from male mice to test the effects of NE and glucocorticoids on inhibitory synaptic inputs of MEC-LII principal cells. Application of NE (100 μM) increased the frequency and amplitude of spontaneous inhibitory post-synaptic currents (sIPSCs) in approximately 75% of the principal cells tested. Unlike NE, bath application of dexamethasone (Dex, 1 μM), a synthetic glucocorticoid, or corticosterone (1 μM) the glucocorticoid in rodents, rapidly decreased the frequency of sIPSCs, but not miniature (mIPSCs) in MEC-LII principal cells. Interestingly, pre-treatment with Dex prior to NE application led to an NE-induced increase in sIPSC frequency in all cells tested. This effect was mediated by the α1-AR, as application of an α1-AR agonist, phenylephrine (PHE) yielded the same results, suggesting that a subset of cells in MEC-LII are unresponsive to α1-AR activation without prior activation of GR. We conclude that activation of GRs primes a subset of principal cells that were previously insensitive to NE to become responsive to α1-AR activation in a transcription-independent manner. These findings demonstrate the ability of stress hormones to markedly alter inhibitory signaling within MEC-LII circuits and suggest the intriguing possibility of modulation of network processing upstream of the hippocampus.
Examining Associations Among ADHD, Homework Behavior, and Reading Comprehension

Previous literature has indicated an important association between reading comprehension and both attention-deficit/hyperactivity disorder (ADHD) and homework habits. This investigation sought to extend previous knowledge by providing information about how ADHD and homework behavior (i.e., completing homework regularly) may jointly influence reading comprehension. Using a genetically sensitive design, this study examined the genetic and environmental influences on and between ADHD, homework behavior and reading comprehension. Participants for this study included 691 twin pairs (351 monozygotic, 340 same-sex dizygotic) from the Florida Twin Project on Behavior and Environment (FTP-BE) and 2647 twin pairs (865 monozygotic, 1782 dizygotic) from the larger Florida Twin Project on Reading (FTP-R) in Grades 3 through 7. Three separate models, each representing a different definition of ADHD (full ADHD, inattention only, and hyperactivity/impulsivity only), showed similar patterns of results; therefore, results of the full ADHD model are discussed. Overlapping genetic influences were found between ADHD, homework behavior, and reading comprehension, but no shared environmental influences among all three. However, shared environmental influences overlapped between homework behavior and reading comprehension. Although the sources of this environmental overlap are unknown, these results have implications for improving homework practices and their subsequent influence on literacy skills through homework environments.