Miracle-dz/UniFAR-FTUs huggingface dataset:
Angiopoietin Balance in Septic Shock Patients With Acute Lung Injury: Effect of Direct Hemoperfusion With Polymyxin B‐Immobilized Fiber

Acute lung injury (ALI) in sepsis is characterized by an increase in microvascular permeability, resulting in pulmonary edema. Several studies have suggested that angiopoietin‐1 and ‐2 play a contributory role in the pathogenesis of ALI. Polymyxin B‐immobilized fiber column hemoperfusion is effective for sepsis‐induced ALI. We investigated the angiopoietin levels before and after direct hemoperfusion with polymyxin B‐immobilized fiber column (PMX) therapy. Enzyme‐linked immunoassay was used to measure the serum angiopoietin‐1 and ‐2 levels in 25 patients with septic shock treated with PMX. Eleven of the 25 patients were diagnosed with ALI. There was a significant positive correlation between the angiopoietin‐1 level and the PaO2/FiO2 ratio, but there was a significant inverse correlation between the angiopoietin‐2 level and the PaO2/FiO2 ratio. The mean angiopoietin‐1 level before PMX therapy in the ALI group was significantly lower and the mean angiopoietin‐2 level was significantly higher than in the non‐ALI group. The mean angiopoietin‐1 level of the ALI patients in response to PMX therapy was increased during PMX therapy, but that of the non‐ALI patients with newly occurring ALI showed a decreased angiopoietin‐1 level. On the other hand, the mean angiopoietin‐2 level of the responders was decreased during PMX therapy, but that of patients with newly occurring ALI showed an increased angiopoietin‐2 level. This result suggested that each angiopoietin‐1 and ‐2 level may play a role in the pathogenesis of ALI and that PMX therapy ameliorates the angiopoietin balance in patients with ALI in sepsis.
Social Network Analysis: Methods and Applications

Part I. Introduction: Networks, Relations, and Structure: 1. Relations and networks in the social and behavioral sciences 2. Social network data: collection and application Part II. Mathematical Representations of Social Networks: 3. Notation 4. Graphs and matrixes Part III. Structural and Locational Properties: 5. Centrality, prestige, and related actor and group measures 6. Structural balance, clusterability, and transitivity 7. Cohesive subgroups 8. Affiliations, co-memberships, and overlapping subgroups Part IV. Roles and Positions: 9. Structural equivalence 10. Blockmodels 11. Relational algebras 12. Network positions and roles Part V. Dyadic and Triadic Methods: 13. Dyads 14. Triads Part VI. Statistical Dyadic Interaction Models: 15. Statistical analysis of single relational networks 16. Stochastic blockmodels and goodness-of-fit indices Part VII. Epilogue: 17. Future directions.
Sectorised horn antenna array using an RF MEMS rotary switch

A sectorised horn antenna array, comprising eight Vivaldi antennas and a single-pole multiple-throw RF MEMS rotary switch, has been demonstrated for the first time. Details of the design and fabrication are presented, together with preliminary measurements for a proof-of-concept prototype which confirm the principle of operation. It is believed that with further work a much higher performance can be achieved.
Construction of an Immobilized Thermophilic Esterase on Epoxy Support for Poly(ε-caprolactone) Synthesis

Developing an efficient immobilized enzyme is of great significance for improving the operational stability of enzymes in poly(ε-caprolactone) synthesis. In this paper, a thermophilic esterase AFEST from the archaeon Archaeoglobus fulgidus was successfully immobilized on the epoxy support Sepabeads EC-EP via covalent attachment, and the immobilized enzyme was then employed as a biocatalyst for poly(ε-caprolactone) synthesis. The enzyme loading and recovered activity of immobilized enzyme was measured to be 72 mg/g and 10.4 U/mg using p-nitrophenyl caprylate as the substrate at 80 °C, respectively. Through the optimization of reaction conditions (enzyme concentration, temperature, reaction time and medium), poly(ε-caprolactone) was obtained with 100% monomer conversion and low number-average molecular weight (Mn < 1300 g/mol). Further, the immobilized enzyme exhibited excellent reusability, with monomer conversion values exceeding 75% during 15 batch reactions. Finally, poly(ε-caprolactone) was enzymatically synthesized with an isolated yield of 75% and Mn value of 3005 g/mol in a gram-scale reaction.
Detailed 3D mapping based on image edge-point ICP and recovery from registration failure

This paper presents a method of 3D mapping using a binocular stereo camera with automatic recovery from registration failure. We employ edge points as map element, and apply a variant of ICP algorithm to the inter-frame registration. The method detects failure in the registration due to erratic camera motion or moving objects and recovers from the failure by searching a good image to resume the registration using edge-point SIFT descriptors. In experiments, our method successfully coped with registration failure in 3D mapping in indoor and outdoor environments under various conditions.
Macrostructure in the narratives of monolingual Finnish and bilingual Finnish–Swedish children

ABSTRACT The narrative macrostructure of 16 Finnish–Swedish bilingual children (M age = 5 years, 8 months) was assessed in both of their languages. In the case of the Finnish language, the macrostructure was compared with that of 16 monolingual same-age peers. The narratives were analyzed for story structure, structural complexity, and internal state terms in two conditions (telling and retelling). There were no differences in macrostructure between the two languages of bilingual children, or between the monolingual and bilingual children. However, the results revealed differences between elicitation tasks. The story structure score for bilingual children was lower in a telling task than in a retelling task in Finnish. Further, the retelling task elicited higher structural complexity and more internal state terms, regardless of the language.
Inhibition of Axotomy-induced Neuronal Apoptosis by Extracellular Delivery of a Bcl-XL Fusion Protein*

Bcl-2 and Bcl-XL prevent neuronal apoptosis during development, neurodegenerative disease, and trauma. To test a new anti-apoptosis strategy for neuroprotection, we engineered nontoxic components of anthrax toxin into a Bcl-XL delivery system. Delivery of Bcl-XL by this system prevented apoptosis of cultured rat cerebellar granule cells and macrophages, and the prevention depended on both the Bcl-XL and the anthrax toxin receptor binding/translocation moieties. Furthermore, neuronal death in vivo in a retinal ganglion cell model of axotomy-induced apoptosis was inhibited by administration of this fusion protein. Thus, Bcl-XL protein can be delivered into cells from the medium or interstitial space, offering a new way to block apoptosis upstream of many caspases and the mitochondria dysfunction phase of apoptosis.
Drosophila melanogaster homologs of the raf oncogene

A murine v-raf probe, representing the kinase domain, was used to identify two unique loci in Drosophila melanogaster DNA. The most closely related to v-raf was mapped by in situ hybridization to position 2F5-6 (Draf-1) on the X chromosome, whereas the other raf-related gene (Draf-2) was found at position 43A2-5 on chromosome 2. The nucleotide and amino acid homologies of Draf-1 to the kinase domain of v-raf are 61 and 65%, respectively. The large amount of a 3.2-kilobase Draf-1 transcript detected in eggs as a maternal message decreases during embryonic development, and significant steady-state levels are observed throughout the remainder of morphogenesis. We speculate that the Draf-1 locus plays an important role in early embryogenesis.
Relational Inference with Freebase

We are interested in developing a method to accurately infer the type of an edge based on the neighboring entities and the local graph structure that it is embedded in. Working with a modified Freebase network, we project a node into a latent space learned from the neighboring relations with different entities and use its affinity to other nodes in such a space for making predictions. With this model, we were able to achieve an accuracy of 94.2%, which is an improvement over the Naive Bayes baseline (84.5%). With this method, we also hope to augment the current knowledge base and discover interesting relationships in the existing Freebase data.
RF MEMS reference oscillator platform with ±0.5ppm frequency stability for wireless handsets

This paper reports on the design of a complete RF MEMS reference oscillator platform to replace bulky quartz in wireless handsets targeting LTE specifications. 106 fs jitter, 76.8 MHz AlN-on-Si reference oscillator is designed with SiO2 layers for passive temperature compensation achieving frequency stability of 105 ppm across temperature ranges of -40°C to 85°C. The oscillator consumes 850 μA, with figure-of-merit FOM of 216 dB. Initial frequency offset of ±8000 ppm and temperature drift errors are combined and further addressed electronically. A novel simple digital compensation circuitry is presented in the paper. The circuit generates a compensation word as an input to 21 bit MASH 1-1-1 sigma delta modulator incorporated in RF LTE fractional N-PLL for frequency compensation. Temperature is sensed using low power band-gap front end circuitry with 12 bits temperature to digital converter TDC characterized by a resolution of 0.075°C, consuming only 4.6 μA. The achieved output frequency stability is ±0.5 ppm over temperature ranges from -40°C to 85°C for the most stringent 700 MHz LTE band.
Energy and spectrum efficiency trade-off for Green Small Cell Networks

Green Small Cell Networks aim at achieving high rates and low powers by offloading users with low signal-to-noise-ratios from macrocell to the pico base station. In this work, we propose to jointly optimise energy efficiency (EE) and spectrum efficiency (SE) such that the network providers can dynamically tune the trade-off parameter for different design requirements. This paper formulates the EE-SE trade-off as a multi-objective optimisation problem (MOP) in the uplink of multi-user two-tier Orthogonal Frequency Division Multiplexing Heterogeneous Networks. Using the weighted sum method, the MOP can be transformed into a single-objective optimisation problem (SOP). The proposed EE and SE trade-off optimisation problem is strictly quasi-concave. Hence, using Dual Decomposition approach, we derive the unique optimal solution. Numerical results demonstrate the effectiveness of the proposed approach and illustrate the fundamental tradeoff between EE and SE for different tradeoff parameters such as maximum transmission power and circuit power.
The pharmacokinetics of HIV protease inhibitor combinations

Purpose of review The clinical use of double-boosted protease inhibitor regimens has evolved recently. This strategy offers a number of unique benefits, including pharmacokinetic enhancement of two different protease inhibitors with low dose ritonavir. We review the pharmacologic rationale for the double-boosted protease inhibitor combinations and the complex drug–drug interactions that occur among different protease inhibitors when co-administered. Recent findings The discovery and widespread clinical use of low dose ritonavir as a pharmacoenhancer of other protease inhibitors has significantly improved the management of HIV infection treatment. This has subsequently led to the development of double-boosted protease inhibitor regimens which have been shown to be effective in heavily pre-treated patients, in whom it is crucial to maintain drug concentrations sufficient to suppress viruses with multiple resistance mutations. Interesting pharmacokinetic data have been recently produced showing the complexity of the interactions among three protease inhibitors. As the outcome of these multidrug interactions may be difficult to predict, formal pharmacokinetic studies have been fundamental to determine which protease inhibitors are best to administer in combination. Summary This review summarizes the current literature regarding the pharmacokinetics of double-boosted protease inhibitor regimens and general considerations regarding their usage in the treatment of HIV-infected patients. Abbreviations ARV: antiretroviral; AUC: area under the concentration–time curve; CYP450: cytochrome P450; NRTI: nucleoside reverse transcriptase inhibitor; TDM: therapeutic drug monitoring.
Decision Making as a Function of Self and others

Subjects read short scenarios involving a conflict of whether to sell or lease a business that they inherited. They were asked to rank points of arguments, for and against to selling or leasing as if (1) they were personally involved in the conflict or (2) they were to support one or the other position taken by a protagonist(s). Some points of argument were responded to differently as a function of one or the other orientations.
The Complexity of Deriving Multi-Labeled Trees from Bipartitions

Recently, multi-labeled trees have been used to help unravel the evolutionary origins of polyploid species. A multi-labeled tree is the same as a phylogenetic tree except that more than one leaf may be labeled by a single species, so that the leaf set of a multi-labeled tree can be regarded as a multiset. In contrast to phylogenetic trees, which can be efficiently encoded in terms of certain bipartitions of their leaf sets, we show that it is NP-hard to decide whether a collection of bipartitions of a multiset can be represented by a multi-labeled tree. Even so, we also show that it is possible to generalize to multi-labeled trees a well-known condition that characterizes when a collection of bipartitions encodes a phylogenetic tree. Using this generalization, we obtain a fixed-parameter algorithm for the above decision problem in terms of a parameter associated to the given multiset.
Longitudinal Phylogenetic Surveillance Identifies Distinct Patterns of Cluster Dynamics

Objective:Through the application of simple, accessible, molecular epidemiology tools, we aimed to resolve the phylogenetic relationships that best predicted patterns of cluster growth using longitudinal population level drug resistance genotype data. Methods:Analysis was performed on 971 specimens from drug naïve, first time HIV positive subjects collected in British Columbia between 2002 and 2005. A 1240bp fragment of the pol gene was amplified and sequenced with relationships among subtype B sequences inferred using Neighbour-Joining analysis. Apparent clusters of infections having both a mean within group distance <0.031 and bootstrap value >80% were systematically identified. The entire 2002-2005 dataset was then re-analyze to evaluate the relationship of subsequent infections to those identified in 2002. BED testing was used to identify recent infections (<156 days). Results:Among the 2002 infections, 136 of 300 sequences sorted into 52 clusters ranging in size from 2 to 9 members. Aboriginal ethnicity and intravenous drug use were correlated, and both were linked to cluster membership in 2002. Although cluster growth between 2002 and 2005 was correlated with the size of the original cluster, more related infections were found in clusters seeded from nonclustered infections. Finally, all large growth clusters were seeded from infections that were much more likely to be recent. Conclusions:This population level phylogenetic analysis suggests that a greater increase in cluster size is associated with recently infected individuals, which may represent the leading edge of the epidemic. The most impressive increase in cluster size is seen originating from initially nonclustered infections. In contrast, smaller existing clusters likely describe historical patterns of transmission and do not substantially contribute to the ongoing epidemic. Application of this method for cross-sectional analysis of existing sequences from defined geographic regions may be useful in predicting trends in HIV transmission.
Aldursbundnar breytingar á þéttni kalkkirtlahormóns kannaðar með mismunandi rannsóknaraðferðum

assays was 0.787 (P<0.001) for women and 0.69 (P<0.001) for men. Kappa statistic was 0.486 (P<0.001) for women and 0.283 (P<0.001) for men, indicating fair to good agreement. PTH elecsys increased with age (P=0.03 and P=0.01 for women and men, respectively) but not PTH cap (P=0.7 and P=0.09 for women and men, respectively). PTH elecsys was positively associated with cystatin C (P<0.05 for both genders), but the correlation between PTH cap and Cystatin C was not statistically significant. The association with body mass index was similar for the two assays (r=0.16 to 0.24, P<0.05) for both genders. Conclusions: There is a significant difference between these two PTH assays. It is likely that increases in intact PTH observed with age and worsening renal function are related to large breakdown products of PTH whereas the PTH increase seen with higher weight seems to be related to PTH(1-84) itself.
The Kissing-Loop Motif Is a Preferred Site of 5′ Leader Recombination during Replication of SL3-3 Murine Leukemia Viruses in Mice

ABSTRACT A panel of mouse T-cell lymphomas induced by SL3-3 murine leukemia virus (MLV) and three primer binding site mutants thereof (A. H. Lund, J. Schmidt, A. Luz, A. B. Sørensen, M. Duch, and F. S. Pedersen, J. Virol. 73:6117–6122, 1999) were analyzed for the occurrence of recombination between the exogenous input virus and endogenous MLV-like sequences within the 5′ leader region. Evidence of recombination within the region studied was found in 14 of 52 tumors analyzed. Sequence analysis of a ∼330-bp fragment of 44 chimeric proviruses, encompassing the U5, the primer binding site, and the upstream part of the 5′ untranslated region, enabled us to map recombination sites, guided by distinct scattered nucleotide differences. In 30 of 44 analyzed sequences, recombination was mapped to a 33-nucleotide similarity window coinciding with the kissing-loop stem-loop motif implicated in dimerization of the diploid genome. Interestingly, the recombination pattern preference found in replication-competent viruses from T-cell tumors is very similar to the pattern previously reported for retroviral vectors in cell culture experiments. The data therefore sustain the hypothesis that the kissing loop, presumably via a role in RNA dimer formation, constitutes a hot spot for reverse transcriptase-mediated recombination in MLV.
Lymphedema in breast cancer: dilemmas and challenges.

D.S. is a 40-year-old woman who completed all treatment for stage III breast cancer six months ago. At the time of diagnosis, a 3 cm mass was found in the upper outer quadrant of her left breast, and she had four positive lymph nodes at the time of definitive surgical treatment. She was treated with partial mastectomy and axillary node dissection followed by adjuvant chemotherapy. She did not need a ventricular assist device. Radiation therapy directed to her whole breast and axilla followed completion of chemotherapy. D.S. is married and works part-time as a computer programmer. Her children are ages 4 and 8. Now she presents for an acute care appointment after noting pain in her upper arm for several days followed one week later by swelling in her left hand. Prior to the onset of symptoms, D.S. had been very active with her daughter’s birthday party held outdoors in August during hot, humid weather.
Dosage Effects on School Readiness: Evidence from a Randomized Classroom-Based Intervention

Variations in the dosage of social interventions and the effects of dosage on program outcomes remain understudied. This study examines the dosage effects of the Chicago School Readiness Project, a randomized, multifaceted classroom-based intervention conducted in Head Start settings. Using a principal score matching method to address the issue of selection bias, the study finds that high-dosage levels of teacher training and mental health consultant class visits have larger effects on children’s school readiness than the effects estimated through intention-to-treat (ITT) analyses. Low-dosage levels of treatment are found to have effects that are smaller than those estimated in ITT analyses or to have no statistically significant program effects. Moreover, individual mental health consultation services provided to high-risk children are found to have statistically significant effects on their school readiness. The study discusses the implications of these findings for research and policy.
Fully-differential low-offset interface for capacitive sensors

A novel fully-differential capacitor measuring circuit is presented in this paper. Baseline drift is reduced by using a reference branch and the offsets of two op-amps are cancelled by each other. The simulation results show that linearity of this measuring circuit achieves 99.98%, baseline drift reduces to 4mV and sensitivity error between simulated result and theoretical calculated result is below 3%.
Proceedings of the International Workshop on Semantic Technologies meet Recommender Systems & Big Data SeRSy 2012 co-located with the :

We present a general and novel framework for predicting links in multirelational graphs using a set of matrices describing the various instantiated relations in the knowledge base. We construct matrices that add information further remote in the knowledge graph by join operations and we describe how unstructured information can be integrated in the model. We show that efficient learning can be achieved using an alternating least squares approach exploiting sparse matrix algebra and low-rank approximations. We discuss the relevance of modeling nonlinear interactions and add corresponding model components. We also discuss a kernel solution which is of interest when it is easy to define sensible kernels. We discuss the relevance of feature selection for the interaction terms and apply a random search strategy to tune the hyperparameters in the model. We validate our approach using data sets from the Linked Open Data (LOD) cloud and from other sources.
A space of one’s own: spatial and identity liminality in an online community of mothers

ABSTRACT This paper investigates the role of an online community in the life of 11 Taiwanese women living in the UK and considers the implications this empirical case has for theorising about motherhood and the spatial dimensions of online/on-site space. Findings from a nethnographic and ethnographic fieldwork show how online discussions reflect and amplify the liminal identities of the community’s members. In looking at doing mothering at a collective rather than at the individual level, this study highlights how collective practices of consumption perpetuate liminal identities, exacerbating consumers’ sense of being out of place. It shows how online space is at the same time the product of online and on-site liminal identities and liminal social interactions and the re-producer of such interactions.