Miracle-dz/UniFAR-FTUs huggingface dataset:
Extreme Maximum Margin Clustering

Maximum margin clustering (MMC) is a newly proposed clustering method that extends the large-margin computation of support vector machine (SVM) to unsupervised learning. Traditionally, MMC is formulated as a nonconvex integer programming problem which makes it difficult to solve. Several methods rely on reformulating and relaxing the nonconvex optimization problem as semidefinite programming (SDP) or second-order cone program (SOCP), which are computationally expensive and have difficulty handling large-scale data sets. In linear cases, by making use of the constrained concave-convex procedure (CCCP) and cutting plane algorithm, several MMC methods take linear time to converge to a local optimum, but in nonlinear cases, time complexity is still high. Since extreme learning machine (ELM) has achieved similar generalization performance at much faster learning speed than traditional SVM and LS-SVM, we propose an extreme maximum margin clustering (EMMC) algorithm based on ELM. It can perform well in nonlinear cases. Moreover, the kernel parameters of EMMC need not be tuned by means of random feature mappings. Experimental results on several real-world data sets show that EMMC performs better than traditional MMC methods, especially in handling large-scale data sets. key words: maximum margin clustering, unsupervised learning, extreme learning machine (ELM), random feature mapping
Comparative efficacy of a proprietary topical ibuprofen gel and oral ibuprofen in acute soft tissue injuries: a randomized, double‐blind study *

The efficacy of a novel, proprietary topical formulation of ibuprofen 5% gel (Ibugel™) and ibuprofen 400 mg tablets (1200 mg daily) was compared in a double‐blind, double‐dummy, parallel group study in patients with acute soft tissue injuries. Patients received either active gel plus placebo tablets (n=50) or active tablets plus placebo gel (n=50) for at least 7 days. The gel was applied and one tablet was taken three times daily. The two treatments showed similar efficacy. There were no significant differences between the groups for either the primary efficacy endpoint, the median time for the injury to be rated as ‘completely better’ by the patients (>14 days active gel, 13·5 days active tablets; P=0·59), or for other efficacy measures including the times to clinically significant relief from pain at rest or on movement and swelling. In summary, ibuprofen gel shows similar efficacy to oral ibuprofen 400 mg and may offer improved tolerability.
Improving the Retrieval of Related Questions in StackOverflow

StackOverflow is a very popular Q&A website, known to all software developers. Developers can either post their coding questions on the website to be answered by other developers or explore the existing questions and their answers to find the solution they are looking for. Finding questions which are related to the desired topic and might include either the exact answer or some hints which can help to resolve the issue is very helpful for users of StackOverflow. This will decrease the time that users have to spend on search engines trying different keywords or waiting on Q&A websites for other users to reply to them. In this work, I aim to improve related posts retrieved for each question in the StackOverflow website through information retrieval techniques customized for this website. The approach is based on text similarity algorithms applied on the content of posted questions including normal text and code. Firstly, I configured the algorithm based on the manual evaluation of the results of a small dataset. Then, I performed a user study with professional developers and graduate students in software engineering for evaluating the approach with the best configuration from the previous step in comparison to existing related posts in the StackOverflow. The results of this study revealed that my approach performs better than the algorithm used in StackOverflow website. Moreover, the statistical analysis of the results proved that this improvement is statistically significant.
Effects of Feedback on the One-sided Secrecy of Two-way Wiretap through Multiple Transmissions

In this paper, the one-sided secrecy of two-way wiretap channel with feedback is investigated, where the confidential messages of one user through multiple transmissions is guaranteed secure against an external eavesdropper. For one thing, one-sided secrecy satisfies the secure demand of many practical scenarios. For another, the secrecy is measured over many blocks since the correlation between eavesdropper's observation and the confidential messages in successive blocks, instead of secrecy measurement of one block in previous works. Thus, firstly, an achievable secrecy rate region is derived for the general two-way wiretap channel with feedback through multiple transmissions under one-sided secrecy. Secondly, outer bounds on the secrecy capacity region are also obtained. The gap between inner and outer bounds on the secrecy capacity region is explored via the binary input two-way wiretap channels. Most notably, the secrecy capacity regions are established for the XOR channel. Furthermore, the result shows that the achievable rate region with feedback is larger than that without feedback. Therefore, the benefit role of feedback is precisely characterized for two-way wiretap channel with feedback under one-sided secrecy.
Modular graphing technique for small-signal low-frequency characterizations of PWM DC/DC regulators

This paper addresses the development of a modular graphing technique for small-signal low-frequency characterizations of pulse-width-modulation (PWM) DC/DC regulators. The methodology starts with the derivation of a unified input sensitivity graph for a single circuit topology to correlate the state-variable sensitivities with the topology duration and the input source. By integrating with previously developed state-variable sensitivity graphing technique, the overall regulator sensitivities in one switching cycle, and hence the small-signal transfer characteristics are obtained by cascading the respective graphs in accordance with the sequence of the topologies. The proposed method is exemplified by analyzing a PWM boost regulator.
Strategies To Reduce Sodium Intake In The United States

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A New Data Assignment Mechanism Based on Genetic Algorithm in P2PVoD System

The data assignment in P2PVoD is in essence a parallel processor issue. Belonging to a NP-hard issue, it is unable to find a polynomial time optimal algorithm. In order to find a global optimized algorithm, a new data assignment mechanism based on Genetic Algorithm is presented in this paper. New methods are designed in this mechanism, such as encoding, fitness-evaluating methods, the punishment function of constricted fitness-evaluating and the patching schema which alleviates source server load. The experiment results indicate that this approach is superior in efficiency and it is propitious to improve the stabilization and expansibility of the system.
A geologic and biostratigraphic framework for Miocene sediments near Khaur Village, northern Pakistan

A litho- and chronostratigraphic framework for approximately 3500 m of late Miocene sedimentary deposits with lateral exposure of 30-40 km is now well established for Siwalik deposits in the vicinity of Khaur Village, north­ ern Pakistan. Based on paleomagnetic rever­ sal stratigraphy and the constraints of long range faunal correlations, the time spanned is between 15-12 and 6 my BP. Boundaries of the major lithostratigraphic units are timetransgressive with respect to a paleomag­ netic isochron traced laterally for 20-30 km. With reference to this datum, the zone of interfingering of the Dhok Pathan and Nagri For­ mations moves upward through approxi­ mately 1.5 my from east to west in the Khaur area. The major rock units represent adjacent alluvial deposits of two or more major fluvial systems with different characteristics of fossil preservation. Nearly 350 fossil-collecting localities can be placed in this litho- and chronostratigraphic framework. These localities span the entire 6-9 my interval, al­ though the lower half of the section is only poorly fossiliferous. The sequence of faunas encompasses Pilgrim's Kamlial through Dhok Pathan faunal zones, but with this new chronostratigraphic framework it is now ap
Level and pattern of HIV-1-RNA viral load over age: differences between girls and boys?

Objective To estimate RNA viral load patterns over age in vertically infected children that account for between- and within-individual variation, treatment and assay cut-off detection level. To investigate possible sex-based differences. Design A total of 118 infected children with 894 RNA viral load measurements enrolled in the European Collaborative Study were prospectively followed from birth for up to 15 years. Methods Fractional polynomial and mixed effects models with censored data to assess the non-linear pattern of viral load over age, allowing for repeated measures. Results The RNA viral load peaked at approximately 3 months of age, and gradually declined thereafter. The sex by age interaction was significant (χ2 = 19.7, P < 0.001); viral load peaked higher for girls than boys, but after 4 years the RNA load was consistently 0.25–0.5 log10 lower for girls than boys. The effects of sex and treatment on viral load vary over age (χ2 = 6.31, P = 0.043). Sex differences in RNA viral load relating to measurement without treatment were more pronounced than those under treatment. Disease progression was more rapid for girls than for boys up to the age of 4 years, and less rapid thereafter; the overall difference was not statistically significant. Conclusion Differences in RNA viral load over age between untreated boys and girls may have implications for policies for the initiation of antiretroviral therapy, but do not seem to translate into differences in progression to serious disease. The findings would suggest underlying biological explanations, which need further investigation.
Sentiment analysis for restaurant rating

The rating systems are important to find the quality of the product or service. These rating systems serve as a guide in finding the perfect one based on different user criteria. Therefore, a sentiment analysis system has been designed for automatic restaurant rating which will be useful to the people in picking their favorite restaurant. The sentiment analysis for restaurant rating system rates the restaurant depending upon the reviews given by the users. The system breaks user comments to check for sentiment keywords. Once the keywords are found, it associates the comment with a sentiment rank. Sentiment analysis can also be extended further to improve the business process. With the customers' reviews, one can understand the changes in the market and improve their product/service. It is also scalable to any type of environment.
Individuals’ feedback trading in market and limit trades: Trading behaviours on the Korean stock market

ABSTRACT Using all of individuals’ transactions on the Korean stock exchange from 1999 to 2009, I find that Korean individuals engage in negative feedback trading in market trades and positive feedback trading in limit trades. These patterns are stronger for smaller stocks and during down-market. These results indicate that the previously documented contrarian trading by individual investors is driven by their unique behavioural preference instead of their heavy use of limit order. Individuals produce relative gains by engaging in negative feedback trading in market trades, indicating that such trading behaviour is not irrational.
Cross-buying as a challenge in emerging markets: a study of the effect of technology adoption on cross-buying intentions

The primary focus of this study is to understand whether the banking customers who are more likely to adopt new technologies will increase their likelihood to buy more products and services from same provider. This aim was achieved by examining the effect of technology adoption by banking customers on their cross-buying intentions for financial services. Data were collected using structured questionnaire and analysed adopting structural equation modelling (SEM). A positive strong association was found between technology adoption and cross-buying intentions. Technology adoption was measured through familiarity, innovativeness and stance to new technologies. The results stress the importance of increasing usage and popularity of electronic channels among banking customers for encouraging cross-buying. The originality of the paper lies in the fact that this study goes one step further from previous research by examining the direct relationship between technology adoptions by banking customers on their cross-buying intentions.
Translational repression of TEM β‐lactamase synthesisas a response of Escherichia coli to heat shock

As a result of a temperature shift‐up from 30°C to 42°C, β‐lactamase synthesis in Escherichia coli carrying pBR322 ceased transiently, even though the level of β‐lactamase mRNA was not altered. pBR328‐directed pre‐β‐lactamase synthesis in an in vitro transcription‐translation coupled system was also repressed by incubation at the higher temperature. Translation of the lacZ sequence from the amp translation start signal, inserted into the open reading frame vector pORF1, was also repressed transiently upon the temperature shift‐up. Pre‐heating of the in vitro coupled system at 45°C specifically reduced its capacity for pre‐β‐lactamase synthesis. This capacity was restored by the addition of a 160000 × g supernatant prepared from E. coli grown at 30°C, but not by the supernatant from the cells incubated at 42°C. These and other results Indicate that (i) the 160000 × g supernatant contains a heat‐labile protein(s) that is required for efficient initiation of the translation of pre‐β‐lactamase mRNA, and (ii) the heat shock‐induced repression of β‐lactamase synthesis is due to inactivation of the protein(s) in the 160000 × g supernatant.
Integral terminal sliding mode formation control of non-holonomic robots using leader follower approach

SUMMARY Multi-robot formation control has become an important area of research due to its advantages and applications. This paper presents multi-robot formation control using a leader–follower approach without considering the leader's velocity information or estimation. The leader–follower formation is formulated by incorporating the model uncertainties and disturbances. A novel formation controller is presented using integral terminal sliding mode (ITSM) control, which drives the formation tracking error convergence to zero in finite-time. The stability of the close-loop control scheme is verified by using Lyapunov theory. Furthermore, obstacle detection and avoidance are incorporated to avoid collision while maintaining the formation. The effectiveness of the proposed controller is verified and validated using sine and lamniscate curve trajectories. Moreover, the performance of the proposed ITSM formation controller is compared with the standard linear sliding mode (LSM) control.
Experimental verification of the Generalized Nyquist stability criterion for balanced three-phase ac systems in the presence of constant power loads

Stability is a great concern for power systems with relatively small sources and multiple regulated power converters. Addressing this need, this paper presents the experimental verification of the Generalized Nyquist stability Criterion (GNC) for balanced three-phase ac systems. This criterion, developed by MacFarlane and Postlethwaite in the 1970's, was proposed as a stability analysis tool for ac interfaces in the d-q frame in the late 1990's. Since then, however, very few papers have addressed the verification of this theory in a real power system given the intricacies of three-phase impedance measurement in the d-q frame. In this paper, a voltage source inverter feeding a boost rectifier is used to implement an experimental balanced three-phase system, where by adjusting their respective control bandwidths, stable and unstable cases are found at their ac interface. To this end, the d-q frame impedances of both converters are measured, and the GNC is applied, showing how both stable and unstable cases can be effectively predicted.
Noninvasive Imaging of Cell-Mediated Therapy for Treatment of Cancer

Cell-mediated therapy (immunotherapy) for the treatment of cancer is an active area of investigation in animal models and clinical trials. Despite many advances, objective responses to immunotherapy are observed in a small number of cases, for certain tumor types. To better understand differences in outcomes, it is critical to develop assays for tracking effector cell localization and function in situ. The fairly recent use of molecular imaging techniques to track cell populations has presented researchers and clinicians with a powerful diagnostic tool for determining the efficacy of cell-mediated therapy for the treatment of cancer. This review highlights the application of whole-body noninvasive radioisotopic, magnetic, and optical imaging methods for monitoring effector cells in vivo. Issues that affect sensitivity of detection, such as methods of cell marking, efficiency of cell labeling, toxicity, and limits of detection of imaging modalities, are discussed.
Impulsive Differential Equations: Asymptotic Properties of the Solutions

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Construction of The Measurement Scale of the Audit Committee Diligence: The Perception of Tunisian Internal Auditors

This paper aims at measuring scales of the audit committee diligence for audit committees or for other governance organ concerned with the audit committee diligence. The conception and the validation of this measurement scales were done on the Tunisian ground. To construct a measure of audit committee diligence, we adopted the Churchill’s approach [18]. That is based on data collected from qualitative and quantitative surveys. The principal component analysis (PCA) on each of the audit committee diligence emerges many axes among the diligence items revealed by Tunisian internal auditors. After that, a confirmatory analysis (CFA) aimed at helping us to validate the proposed model. Accordingly this approach developed a scale of 11diligence indicators distributed on two factors.
Facilitating accessibility and digital inclusion using gaze-aware wearable computing

Gaze interaction has been helping people with physical disabilities for many years but its use is still limited, in part because it has been designed for desktop platforms. In this paper we discuss how gaze-aware wearable computing can be used to create new applications that can significantly enhance the quality of life of people with disabilities, including the elderly, and also be used to promote digital inclusion for illiterate people.
Quantitative Proteomics Profiling of Murine Mammary Gland Cells Unravels Impact of Annexin-1 on DNA Damage Response, Cell Adhesion, and Migration*

Annexin 1 (ANXA1), the first characterized member of the annexin superfamily, is known to bind or annex to cellular membranes in a calcium-dependent manner. Besides mediating inflammation, ANXA1 has also been reported to be involved in important physiopathological implications including cell proliferation, differentiation, apoptosis, cancer, and metastasis. However, with controversies in ANXA1 expression in breast carcinomas, its role in breast cancer initiation and progression remains unclear. To elucidate how ANXA1 plays a role in breast cancer initiation, we performed stable isotope labeling of amino acids in cell culture analysis on normal mammary gland epithelial cells from ANXA1-heterozygous (ANXA1+/−) and ANXA1-null (ANXA1−/−) mice. Among over 4000 quantified proteins, we observed 214 up-regulated and 169 down-regulated with ANXA1−/−. Bioinformatics analysis of the down-regulated proteins revealed that ANXA1 is potentially implicated in DNA damage response, whereas the analysis of up-regulated proteins showed the possible roles of ANXA1 in cell adhesion and migration pathways. These observations were supported by relevant functional assays. The assays for DNA damage response demonstrated an accumulation of more DNA damage with slower recovery on heat stress and an impaired oxidative damage response in ANXA1−/− cells in comparison with ANXA1+/− cells. Overexpressing Yes-associated protein 1 or Yap1, the most down-regulated protein in DNA damage response pathway cluster, rescued the proliferative response in ANXA1−/− cells exposed to oxidative damage. Both migration and wound healing assays showed that ANXA1+/− cells possess higher motility with better wound closure capability than ANXA1−/− cells. Knocking down of β-parvin, the protein with the highest fold change in the cell adhesion protein cluster, indicated an increased cell migration in ANXA1−/− cells. Altogether our quantitative proteomics study on ANXA1 suggests that ANXA1 plays a protective role in DNA damage and modulates cell adhesion and motility, indicating its potential role in cancer initiation as well as progression in breast carcinoma.
Special Issue on Design and Development: Developing Products on "Internet Time": The Anatomy of a Flexible Development Process

Uncertain and dynamic environments present fundamental challenges to managers of the new product development process. Between successive product generations, significant evolutions can occur in both the customer needs a product must address and the technologies it employs to satisfy these needs. Even within a single development project, firms must respond to new information, or risk developing a product that is obsolete the day it is launched. This paper examines the characteristics of an effective development process in one such environment-the Internet software industry. Using data on 29 completed development projects we show that in this industry, constructs that support a more flexible development process are associated with better-performing projects. This flexible process is characterized by the ability to generate and respond to new information for a longer proportion of a development cycle. The constructs that support such a process are greater investments in architectural design, earlier feedback on product performance from the market, and the use of a development team with greater amounts of "generational" experience. Our results suggest that investments in architectural design play a dual role in a flexible process: First, through the need to select an architecture that maximizes product performance and, second, through the need to select an architecture that facilitates development process flexibility. We provide examples from our fieldwork to support this view.