Miracle-dz/UniFAR-FTUs huggingface dataset:
Non-Convexity and the Optimal Allocation of Risk in an Exchange Economy

The traditional approach to demand analysis has generally assumed that preferences, prices, in come, and the quality of goods are all known with certainty. In many consumer decisions, uncertain ty can be neglected without serious consequences, but in others, uncertainty is at the heart of the problem. There is, for example, uncertainty in the selection of a desired portfolio of securities by con sumer units. Professor Arrow has presented a model in which both securities and uncertainty are introduced [1]. His model is an extension of de mand theory under conditions of certainty. The theory begins by postulating the objects of choice (claims on commodities) to be dependent on alternative states of nature. The occurrence of a certain state is known only on the basis of subjec tive probabilities. This approach parallels, almost exactly, the orthodox approach to demand theory where preference functions have a domain of com modity space. In reality, allocations are made by claims (securities) payable in money, not in com modities. The usual situation is that securities are sold which are payable in money, the amount depending on which state of nature has oc curred. The importance of Arrow's model is to do away with, in some sense, the claims on com modities, and to introduce securities payable in money. Once a particular state has occurred, the individual allocates his money income from the security in the usual manner. Arrow defines a Pareto efficient allocation of claims on commodities in an exchange economy. He shows that if a certain utility func tion is quasi-concave, along with other fairly traditional assumptions, there exists, for any Pareto efficient allocation of claims on com modities, a set of security prices, commodity prices, and incomes such that consumers, max imizing utility, subject to a budget constraint in volving these security prices, commodity prices, and incomes, will attain that Pareto efficient allocation. The securities are payable in money. The amount depends on the state of nature that occurs.
Dynamics of Aβ Turnover and Deposition in Different β-Amyloid Precursor Protein Transgenic Mouse Models Following γ-Secretase Inhibition

Human β-amyloid precursor protein (APP) transgenic mice are commonly used to test potential therapeutics for Alzheimer's disease. We have characterized the dynamics of β-amyloid (Aβ) generation and deposition following γ-secretase inhibition with compound LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-l-alaninamide]. Kinetic studies in preplaque mice distinguished a detergent-soluble Aβ pool in brain with rapid turnover (half-lives for Aβ40 and Aβ42 were 0.7 and 1.7 h) and a much more stable, less soluble pool. Aβ in cerebrospinal fluid (CSF) reflected the changes in the soluble brain Aβ pool, whereas plasma Aβ turned over more rapidly. In brain, APP C-terminal fragments (CTF) accumulated differentially. The half-lives for γ-secretase degradation were estimated as 0.4 and 0.1 h for C99 and C83, respectively. Three different APP transgenic lines responded very similarly to γ-secretase inhibition regardless of the familial Alzheimer's disease mutations in APP. Amyloid deposition started with Aβ42, whereas Aβ38 and Aβ40 continued to turn over. Chronic γ-secretase inhibition lowered amyloid plaque formation to a different degree in different brain regions of the same mice. The extent was inversely related to the initial amyloid load in the region analyzed. No evidence for plaque removal below baseline was obtained. γ-Secretase inhibition led to a redistribution of intracellular Aβ and an elevation of CTFs in neuronal fibers. In CSF, Aβ showed a similar turnover as in preplaque animals demonstrating its suitability as marker of newly generated, soluble Aβ in plaque-bearing brain. This study supports the use of APP transgenic mice as translational models to characterize Aβ-lowering therapeutics.
GROWTH CHARACTERISTICS OF ORNAMENTAL JUDAS TREE (Cercis siliquastrum L.) SEEDLINGS UNDER DIFFERENT CONCENTRATIONS OF LEAD AND CADMIUM IN IRRIGATION WATER

Landscape plantations are significantly water demanding in many parts of the world, particularly in dry regions. Adequate water supply is the main limiting factor behind landscape development, maintenance and beauty in such environments. On the other hand, monitoring the growth response of ornamental and landscape plants to irrigation water containing heavy metals can be useful in management and application of municipal wastewaters to these plantations instead of application in edible vegetable crops production, which is common in many urban areas. In the present study, one year old seedlings of Judas tree (Cercis siliquastrum) were irrigated for two years with water containing 0, 15 or 30 mg L–1 of lead (Pb) in absence or presence of cadmium (0 or 5 mg L–1) in a factorial design, and under greenhouse conditions. Heavy metal treatments had no significant effect on leaf SPAD value; however, plants treated with Pb15Cd0 combination had significantly higher SPAD value than Pb30Cd5 combination that showed the lowest leaf SPAD value. Increasing the lead and cadmium levels of irrigation water increased the number of chlorotic and necrotic leaves of plant than control, whereas it reduced the average leaf area and new shoot growth. The control plants or plants treated with lower level of heavy metals showed the highest leaf area and new shoot growth. Leaf photosynthesis rate was significantly reduced in all heavy metal treated plants than control plants, as the lowest amount was in Pb30Cd5 combination treatment. All heavy metal treatments showed higher leaf soluble carbohydrates and proline content than in control plants. Leaf soluble carbohydrates were highest in Pb30Cd0 and Pb30Cd5 treatments, and leaf proline was highest in Pb30Cd5 and Pb15Cd5 treatments. The results indicate that Judas tree is a relatively tolerant species to high concentrations of Pb and Cd in root medium added through the irrigation water, and long term dual application of these heavy metals can have additive harmful effects on plant growth.
Immunohistochemical detection of a novel 22- to 25-kilodalton glycoprotein of Paracoccidioides brasiliensis in biopsy material and partial characterization by using species-specific monoclonal antibodies

Two murine monoclonal antibodies (MAbs) specific to Paracoccidioides brasiliensis (as determined by enzyme-linked immunosorbent assay [ELISA] and Western blot [immunoblot]) were produced by using a modification of standard hybridization protocols, with cyclophosphamide included as an immunomodulator to abolish responses to highly cross-reactive immunodominant epitopes. MAbs PS14 and PS15 are two different clones which exhibit similar characteristics by ELISA and Western blot. They are directed against a 22- to 25-kDa antigen which is present in P. brasiliensis and which could not be identified in other dimorphic fungi by ELISA or Western blot. Partial purification of the antigen was accomplished by isoelectric focusing, and deglycosylation studies suggested that the 22- to 25-kDa antigen is a glycoprotein with a pI of between 4.5 and 5 and that O-linked sugars may be part of the recognized epitope. The MAbs stained the cytoplasm of P. brasiliensis yeast and hyphal cells in cryostat sections of fresh cultures of the fungus. In addition, the MAbs stained the wall of paracoccidioidomycotic granulomas, as well as the cytoplasm of the fungus, as determined by the use of immunofluorescence, immunoperoxidase, and immuno-alkaline phosphatase staining techniques in paraffin-embedded sections of human biopsy material, and they failed to stain granulomas resulting from other clinical conditions. These findings suggest that these MAbs have potential use in the immunohistochemical identification of P. brasiliensis.
An Independent Evaluation of the CryoXtract Instruments' CXT350 Frozen Sample Aliquotter Using Tissue and Fecal Biospecimens.

The ability to take targeted multiple cores from a single frozen biospecimen would enable several research projects to be fueled from one biospecimen, a small piece of tissue to be quality-control tested, and for pathologically-discrete areas of a biospecimen (e.g., tumor, stromal, and normal tissue) to be selectively sampled for comparative analyses. CryoXtract Instruments' CXT350 Frozen Sample Aliquotter can potentially achieve this by producing multiple cores from one cryopreserved biospecimen without thawing either the parent biospecimen or its daughter cores. It therefore has the potential to add significant value to a tissue banking workflow. We have evaluated its performance while using 614 cores from fecal, liver, kidney, lung, heart, and colon biospecimens. Coring densities of up to five complete and four fragmentary cores per cm(3) are achievable using 3 mm coring probes. Median core weights for tissue were 14.1-17.2 mg (depending on tissue type) and cores ≤325 mg could be taken from fecal biospecimens (depending on the fill-depth of the tube). The coefficient of variation for multiple cores taken from a fecal biospecimen was 11.7%. Between-sample contamination did not occur. RNA Integrity numbers and qRT-PCR analysis demonstrated that coring induced a statistically significant impact on RNA quality that was inconsequential in magnitude and in our view does not represent a barrier for the effective utilization of the technology.
Paternalistic Preferences, Interpersonal Transfers and Reciprocity

Anthropologists since Bronislaw Malinowski [20] and Marcel Mauss [21] have observed that reciprocity is the primary defining characteristic of voluntary interpersonal transfers. While this perspective developed from observation of behaviors in exotic societies (e.g., the "kula ring" of Eastern New Guinea and the "potlatch" of the Kwakiutl tribe of the Pacific Northwest), contemporary observers find reciprocity to be an important feature of interpersonal transfers in modern societies' as well [7; 13; 14]. Sociologists such as Alvin Gouldner [17] and Claude Levi-Strauss [19] have given reciprocity the status of a social norm. Members of society are held to have a three-part obligation: to give gifts; to accept gifts; and to respond to a gift with a gift in return. In this literature, gift exchange serves to establish, perpetuate and define social relationships. Robert Sugden [25] suggests that social conventions and norms enable people to coordinate their behavior in the face of multiple Nash equilibria, where there is no uniquely rational choice and hence rationality alone is insufficient for decision-making. The purpose of this note is to demonstrate, by means of an example, how the norm of reciprocity can play this role in supporting transfers as the equilibrium of non-cooperative behavior. The example is based on the "paternalistic preferences" model that Robert Pollak [22] proposed as an extension of Gary Becker's [6] model of altruism in the family. Where Becker assumes that children's utility levels enter as arguments in their parents' utility function, Pollak assumes that in addition children's levels of consumption of certain goods directly affect parents' utility.2 Thus, Becker assumes that parental utility has the form UP(CP, Ui(Ci), Uj(CJ)), where UP, Ui, and Uj denote the utility functions of the parent and children i and j respectively, and CP, Ci and C' denote their respective consumption vectors. Pollak assumes instead that parental utility is given by UP (CP, Ci, Cj, Ui(Ci), Uj (C)), where the derivatives of UP with respect to the various elements of C' and Cj differ. This explains why intergenerational transfers within families are often tied to the children's consumption of particular goods or even take the form of in-kind transfers to the
Current Trends in the Molecular Classification of Renal Neoplasms

Renal cell carcinoma (RCC) is the most common form of kidney cancer in adults. RCC is a significant challenge for pathologic diagnosis and clinical management. The primary approach to diagnosis is by light microscopy, using the World Health Organization (WHO) classification system, which defines histopathologic tumor subtypes with distinct clinical behavior and underlying genetic mutations. However, light microscopic diagnosis of RCC subtypes is often difficult due to variable histology. In addition, the clinical behavior of RCC is highly variable and therapeutic response rates are poor. Few clinical assays are available to predict outcome in RCC or correlate behavior with histology. Therefore, novel RCC classification systems based on gene expression should be useful for diagnosis, prognosis, and treatment. Recent microarray studies have shown that renal tumors are characterized by distinct gene expression profiles, which can be used to discover novel diagnostic and prognostic biomarkers. Here, we review clinical features of kidney cancer, the WHO classification system, and the growing role of molecular classification for diagnosis, prognosis, and therapy of this disease.
Phytohormone metabolism in human cells: Cytokinins are taken up and interconverted in HeLa cell culture

Cytokinins (CKs) encompass a group of phytohormones, known to orchestrate many critical processes in plant development. Excluding Archaea, CKs are pervasive among all kingdoms, but much less is reported about their metabolism beyond plants. Recent evidence from mammalian tissues indicates the presence of six additional CK forms beyond the previously identified, single mammalian CK, N6‐isopentenyladenosine (i6A). There is limited understanding of CK biosynthesis pathways in mammalian systems; therefore, human cervical cancer (HeLa) cells were used to further characterize CK processing by tracking the interconversion of CKs into their various structural derivatives in mammalian cells in a time‐course study. Through high‐performance liquid chromatography‐positive electrospray ionization‐tandem mass spectrometry (HPLC‐(+ESI)‐MS/MS), we document changes in the functional profiles of endogenous CKs in a human cell line following metabolism by HeLa cell cultures. The nucleotide CK fraction (iPRP) was found exclusively within the cell pellet (0.34 pmol/106 cells), and the active free base (FB) form (iP) and riboside fraction (iPR) were found in greater abundance extracellularly (1.67 and 0.10 nmol/L respectively). For further confirmation, we demonstrate that HeLa cells metabolize an exogenously supplied CK, N6‐benzyladenosine (BAR). In the HeLa culture supernatant, a 12‐fold decrease in BAR concentration was observed within the first 24 hours of incubation accompanied by a fivefold increase in the FB form, N6‐benzyladenine (BA). These findings support the hypothesis that HeLa cells have the enzymatic pathways required for the metabolism of both endogenous and exogenous CKs.
Substituting Distribution for Growth: The Political Logic of Intergovernmental Transfers in the Russian Federation

Given limited resources and economic realities, how do politicians distribute monetary transfers in order to retain office? Previous work has largely focused on two models – a core model of rewarding loyal supporters and a swing model of purchasing the support of easily swayed voters. Empirical results have proven mixed, however. In this article, we argue that these mixed results are due to economic factors, which condition politicians' distributive strategies. In our model, we consider that politician and voters are involved in a repeated game, where past expectations condition future strategy. Current (core) supporters who receive few benefits and perceive themselves worse off than other, less loyal, groups are likely to be less loyal themselves tomorrow. In our model, politicians avoid this by providing their supporters consumption benefits directly, in the form of transfers, or indirectly, via strong economic growth. Where economic growth is good, politicians can distribute less to core supporters, who benefit from the rising economy. Where economic growth is weak, however, politicians make transfers to their core supporters to ensure future loyalty. We test our theory using data on federal transfers from the Russian Federal government to 78 Russian Regions from 2000–2008.
Research on carbon emission trading mechanisms: current status and future possibilities

In the year of 2005, the EU ETS came into effect. After then, carbon trading markets have been emerging across the world and a large number of studies have been conducted about the mechanisms of carbon trading. However, as an emerging market, carbon trading still faces many obstacles and needs more profound research support. For this reason, this paper reviews current related research progress on carbon trading market mechanisms, mainly including carbon emissions allowance allocation, carbon asset pricing and carbon price risk measurement. And then the paper discusses the limitations of existing research and puts forward some possible research directions in the future. Hopefully, the paper is helpful to better understand the research status and problems, and more importantly provide some references to optimise the carbon trading operations.
Isolation and characterization of Clostridium acetobutylicum mutants with enhanced amylolytic activity

Clostridium acetobutylicum mutants BA 101 (hyperamylolytic) and BA 105 (catabolite depressed) were isolated by using N-methyl-N'-nitro-N-nitrosoguanidine together with selective enrichment on the glucose analog 2-deoxyglucose. Amylolytic enzyme production by C. acetobutylicum BA 101 was 1.8- and 2.5-fold higher than that of the ATCC 824 strain grown in starch and glucose, respectively. C. acetobutylicum BA 105 produced 6.5-fold more amylolytic activity on glucose relative to that of the wild-type strain. The addition of glucose at time zero to starch-based P2 medium reduced the total amylolytic activities of C. acetobutylicum BA 101 and BA 105 by 82 and 25%, respectively, as compared with the activities of the same strains grown on starch alone. Localization studies demonstrated that the amylolytic activities of C. acetobutylicum BA 101 and BA 105 were primarily extracellular on all carbohydrates tested.
The Role of Representation Strength of the Prime in Subliminal Visuomotor Priming

This study investigated the role of representation strength of the prime in subliminal visuomotor priming in two experiments. Prime/target compatibility (compatible and incompatible) and preposed object type (jumbled lines, strong masking; and rectangular outlines, weak masking) were manipulated in Experiment 1. A significant negative compatibility effect (NCE) was observed in the rectangle condition, whereas no compatibility effect was found in the line condition. However, when a new variable, prime duration, was introduced in Experiment 2, the NCE was reversed with an increase in the prime duration in the rectangle condition, whereas the NCE was maintained in the line condition. This result is consistent with the claim that increasing the prime duration causes the prime representation to be too strong for inhibition in the rectangle condition but strong enough to reliably trigger inhibition in the line condition. The findings demonstrated that prime representation has a causal role in subliminal visuomotor priming.
RSVP: A Real-Time Surveillance Video Parsing System with Single Frame Supervision

In this demo, we present a real-time surveillance video parsing (RSVP) system to parse surveillance videos. Surveillance video parsing, which aims to segment the video frames into several labels, e.g., face, pants, left-legs, has wide applications, especially in security filed. However, it is very tedious and time-consuming to annotate all the frames in a video. We design a RSVP system to parse the surveillance videos in real-time. The RSVP system requires only one labeled frame in training stage. The RSVP system jointly considers the segmentation of preceding frames when parsing one particular frame within the video. The RSVP system is proved to be effective and efficient in real applications.
Purification of cereolysin and the electrophoretic separation of the active (reduced) and inactive (oxidized) forms of the purified toxin

Cereolysin was purified to apparent homogeneity by using ammonium sulfate fractionation, hydrophobic chromatography with AH-Sepharose, isoelectric focusing, and gel filtration. The active form of the toxin had an isoelectric point of 6.6, and the molecular weight of the protein was about 55,500 as judged by sodium dodecyl sulfate-gel electrophoresis, gel filtration, and gel electrophoresis using various concentrations of acrylamide. Cereolysin contained two half-cystine residues and was dependent on reducing agents, such as dithiothreitol, for maximal hemolytic activity and charge homogeneity. By using discontinuous acrylamide electrophoresis, two forms of the toxin could be observed: oxidized and reduced. If the toxin was purified in the absence of dithiothreitol, partial spontaneous oxidation resulted in the formation of an oxidized form of the toxin. Relative to the reduced form, the oxidized form moved slightly closer to the anode in gel electrophoresis at pH 9.0. If the toxin was purified in the presence of 5 mM dithiothreitol or if the spontaneously oxidized toxin was preincubated with dithiothreitol, only the reduced form of the protein was observed. When the logarithims of their relative mobilities were plotted against the concentration of acrylamide in the gels, the slopes for the reduced and oxidized forms were identical. This indicates that the two forms are identical in size and are separable because of different charges. The reduced protein could be inhibited by N-ethylmaleimide, 5,5'-dithiobis(2-nitrobenzoic acid), and p-hydroxymercuribenzoate. Inhibition by the latter two sulfhydryl reagents could be completely reversed by dithiothreitol. The reversibly oxidized form of the toxin did not appear to be inhibited by N-ethylmaleimide and apparently was either unable to bind to or had a decreased affinity for the erythrocyte membrane.
Skills and Strategies of African American Parents in the Management of ADHD: A Qualitative Study

Objective: The purpose of this study is to use a strengths-based approach to determine African American parents’ skills and strategies for management of children with ADHD. Method: Four focus groups were conducted to identify African American parent beliefs about appropriate ADHD management. Sixteen parents participated and reported having a total of 21 children diagnosed with ADHD. Results: Participants discussed several parenting challenges but advocated for the child by working closely with the child’s school and physician. They also managed relationships with family members to protect the child from possible physical or emotional harm. However, parents desired more social support for management of ADHD. Conclusion: African American parents possess key skills and strategies in their management of children with ADHD. Further research is needed to determine the roles and responsibilities of extended family members for children with this disorder, and to identify the social supports parents access to aid with ADHD management.
Understanding Small and Medium Scale Tilapia Culture in Nicaragua

75 Introduction. 76 Conceptual framework. 89 Methodology. 92 Results and discussion. 93 x Conclusions. 111 Literature cited. 117 V. SUMMARY. 124 VI. BIBLIOGRAPHY. 127 VII. APPENDICES. 137 Appendix A. Questionnaire for institutional analysis. 138 Appendix B. Questionnaire of socio-economic survey. 141