Miracle-dz/UniFAR-FTUs huggingface dataset:
Traffic Allocation for Low-Latency Multi-Hop Millimeter-Wave Networks with Buffers

For millimeter-wave (mm-wave) buffer-aided tandem networks consisting of relay nodes and multiple channels per hop, we consider two traffic allocation schemes, namely local allocation and global allocation, and investigate the end-to-end latency of a file transfer. We formulate the problem for generic multi-hop queuing systems and subsequently derive closed-form expressions of the end-to-end latency. We quantify the advantages of the global allocation scheme relative to its local allocation counterpart, and we conduct an asymptotic analysis on the performance gain when the number of channels in each hop increases to infinity. The traffic allocations and the analytical delay performance are validated through simulations. Furthermore, taking a specific two-hop mm-wave network as an example, we derive lower bounds on the average end-to-end latency, where Nakagami-$m$ fading is considered. Numerical results demonstrate that, compared to the local allocation scheme, the advantage of global allocation grows as the number of relay nodes increases, at the expense of higher complexity that linearly increases with the number of relay nodes. It is also demonstrated that a proper deployment of relay nodes in a linear mm-wave network plays an important role in reducing the average end-to-end latency, and the average latency decays as the mm-wave channels become more deterministic. These findings provide insights for designing multi-hop mm-wave networks with low end-to-end latency.
Content based image authentication with error correction

A watermarking scheme for content based image authentication is proposed which, in addition to authentication, has the ability to localize and correct modifications / errors. The watermark is based on the frequency domain features of an image and it is protected using error correcting codes. The use of error correcting codes helps in error localization and correction. The frequency domain features are additionally protected using an approximate message authentication code. This provides tolerance in image authentication when some of the image data cannot be reconstructed due to transmission errors or by legitimate image processing operations such as quantization, compression etc. The minor variations in the image data might not change the content of the image and therefore by correcting some errors, and being tolerant to the errors below a pre defined threshold, results in successful content authentication. Simulation results support that some unintentional data modifications, such as those due to minor channel noise, can be localized and corrected resulting in successful content authentication. Additionally, the simulation results for intentional modifications show the error localization and forgery detection capability of the proposed algorithm.
N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine

Cyclin-dependent kinases (CDKs) and their regulators show frequent abnormalities in tumors. Ten low molecular weight pharmacologic inhibitors of CDKs are currently in clinical trials against various cancers, including the 2,6,9-trisubstituted purine (R)-roscovitine (CYC202/Seliciclib). We here report the characterization of N-&-N1, a bioisoster of roscovitine displaying improved antitumoral properties. N-&-N1 shows exquisite selectivity for CDKs, with 2- to 3-fold enhanced potency compared with (R)-roscovitine. Inhibition of retinoblastoma protein phosphorylation and RNA polymerase II Ser2 phosphorylation in neuroblastoma SH-SY5Y cells exposed to N-&-N1 indicates that N-&-N1 is able to inhibit CDKs in a cellular context. N-&-N1 also down-regulates the expression of RNA polymerase. Cocrystal structures of N-&-N1 and (R)-roscovitine in complex with CDK2/cyclin A reveal that both inhibitors adopt similar binding modes. A competitive assay shows that, compared with (R)-roscovitine, N-&-N1 has reduced affinity for Erk2 and pyridoxal kinase. N-&-N1 triggers cell death in a panel of diverse cell lines. Cell death is accompanied by events characteristic of apoptosis: cytochrome c release, activation of effector caspases, and poly(ADP-ribose) polymerase cleavage. Induction of p53 and p21CIP1 and down-regulation of the Mcl-1 antiapoptotic factor were also observed. Studies in mice show that N-&-N1 has pharmacokinetics properties similar to those of (R)-roscovitine. Altogether, these results show that analogues of (R)-roscovitine can be designed with improved antitumor potential. [Mol Cancer Ther 2008;7(9):2713–24]
BrownPepper: A SystemC-based simulator for performance evaluation of Networks-on-Chip

The design space of Networks-on-Chip (NoCs) is very large, and there are several architectural alternatives for implementation. In order to select the best configuration of a NoC for a given application, it is necessary to have tools which aid the designer in the evaluation of each configuration. In this context, this work presents an integrated environment based on SystemC which allows evaluating different configurations of a NoC by means of simulation. The SystemC models are implemented by using RTL (Register Transfer Level) and mixed RTL/TL (Transaction Level) modeling. The simulator includes an interface that automates the design and the execution of experiments. It also provides instruments for performance evaluation by using graphical tools which make easier the analysis of results.
Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects.

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a key component in adipocyte differentiation and fat-specific gene expression and may modulate macrophage functions, like proinflammatory activities, and stimulate oxidized low-density lipoprotein (ox-LDL) uptake. We hypothesized that the Pro12Ala polymorphism of the PPAR-gamma2 gene may affect the immune response to ox-LDL. Therefore, we investigated the association of the Pro12Ala polymorphism of the PPAR-gamma2 gene with ox-LDL autoantibodies, as well anticardiolipin antibodies, in a 10-year prospective study. The Pro12Ala polymorphism was genotyped in 119 nondiabetic subjects (age, 45 to 64 years; body mass index [BMI], 19 to 46 kg/m(2)) and 70 type 2 diabetic patients (age, 45 to 65 years; BMI, 19 to 46 kg/m(2)) by the polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) method. Ox-LDL autoantibodies and anticardiolipin antibodies were determined at baseline and after 10 years of follow-up. At baseline, the Pro12Ala polymorphism was not associated with ox-LDL autoantibodies in nondiabetic subjects, whereas type 2 diabetic patients having the Pro12Ala or the Ala12Ala genotypes tended to have higher levels of ox-LDL autoantibodies than did type 2 diabetic patients with the Pro12Pro genotype. At the 10-year follow-up, diabetic subjects having the Ala12 allele had higher ox-LDL autoantibody levels than did diabetic subjects with the Pro12Pro genotype (P =.043 after adjustment for age, gender, BMI, and hemoglobin A(1c) [HbA(1c)] at 5 years). In nondiabetic subjects and regarding anticardiolipin antibodies, no such relationship was observed. We conclude that the Pro12Ala polymorphism of the PPAR-gamma2 gene was associated with increased ox-LDL autoantibodies in type 2 diabetic subjects. Genotype may therefore modulate the oxidative modification of LDL in hyperglycemic milieu.
Suboptimal Event-Triggered Control for Time-Delayed Linear Systems

This technical note considers event-triggering conditions and controller synthesis approaches for delayed linear systems. Optimization problems for minimizing the upper bound of quadratic cost functions are formulated in the form of linear matrix inequalities (LMIs). By solving the optimization problems a unique control gain can be obtained. The performance considered in this technical note includes a linear quadratic cost function for quantifying the control performance and average event times at which the control input must be updated for quantifying the transmission reductions. Comparisons with other approaches in the literature are given to demonstrate the advantages with respect to the two performance indices. Furthermore, an experimental implementation of the proposed methods in an inverted pendulum system shows the applicability and effectiveness in real world.
Extending dichotomous choice contingent valuation methods to pre-test-market evaluation: the case of a cable television service

The purpose of this paper is to introduce and test an extension of dichotomous choice contingent valuation methods to pre-test-market evaluation using the specific case of a cable television service. On the whole, respondents accepted the contingent market and were willing to contribute a significant amount, on average. This willingness varies according to individual characteristics and concerns about the service. It is concluded that the methods are potentially a useful tool for decision-makers in considering the provision of the service.
The Role of the Public Sector in Rural Tourism: Respondents' Views

Using a four round Delphi survey, a focus group and semi-structured interviews, this study investigates the respondent perspective of the public sector role in providing an environment conducive to the development of the rural tourism sector in Britain and South Africa. Although South African respondents generally perceived a greater need of support for the rural tourism sector than did their British counterparts, many of the problems, concerns and frustrations that emerged from the study were similar. Respondents perceived the public sector as ‘leader’, ‘strategist’, ‘mentor’, ‘co-ordinator’, ‘champion’ and ‘partner’ in their endeavour to build the rural tourism sector. Grappling with the problems of uplifting the quality, viability and communal benefit of rural tourism is seen as a futile exercise if the facilitatory platform of rational policy, planning and support conducive to the sustainability of the sector, is not in place. Above all local authorities are seen as ‘the enabler’ of successful rural tourism projects that diversify the local economy and generate employment and entrepreneurial opportunities. However, whilst there is respondent acknowledgement of the role played by the public sector, there is evidence of widespread disenchantment with the efficacy with which this role is fulfilled.
Foresight Study on the Risk Governance of New Technologies: The Case of Nanotechnology

Technology‐led innovation represents an important driver of European economic and industrial competitiveness and offers solutions to societal challenges. In order to facilitate responsible innovation and public acceptance, a need exists to identify and implement oversight approaches focused on the effective risk governance of emerging technologies. This article describes a foresight study on the governance of new technologies, using nanotechnology as a case example. Following a mapping of the governance landscape, four plausible foresight scenarios were developed, capturing critical uncertainties for nanotechnology governance. Key governance elements were then stress tested within these scenarios to see how well they might perform in a range of possible futures and to inform identification of the strengths, weaknesses, opportunities, and threats for nanotechnology governance in Europe. Based on the study outcomes, recommendations are proposed regarding the development of governance associated with the responsible development of new technologies.
Mapping of Binding Domains of NontypeableHaemophilus influenzae HMW1 and HMW2 Adhesins

ABSTRACT Nontypeable Haemophilus influenzae is an important cause of localized respiratory tract disease, which begins with colonization of the upper respiratory mucosa. In previous work we reported that the nontypeable H. influenzae HMW1 and HMW2 proteins are high-molecular-weight nonpilus adhesins responsible for attachment to human epithelial cells, an essential step in the process of colonization. Interestingly, although HMW1 and HMW2 share significant sequence similarity, they display distinct cellular binding specificities. In order to map the HMW1 and HMW2 binding domains, we generated a series of complementary HMW1-HMW2 chimeric proteins and examined the ability of these proteins to promote in vitro adherence byEscherichia coli DH5α. Using this approach, we localized the HMW1 and HMW2 binding domains to an ∼360-amino-acid region near the N terminus of the mature HMW1 and HMW2 proteins. Experiments with maltose-binding protein fusion proteins containing segments of either HMW1 or HMW2 confirmed these results and suggested that the fully functional binding domains may be conformational structures that require relatively long stretches of sequence. Of note, the HMW1 and HMW2 binding domains correspond to areas of maximal sequence dissimilarity, suggesting that selective advantage associated with broader adhesive potential has been a major driving force duringH. influenzae evolution. These findings should facilitate efforts to develop a subcomponent vaccine effective against nontypeableH. influenzae disease.
Institutional conditions for complementarities between urban leadership and community involvement

Institutional arenas may be regarded as the context in which actors ‘interact’ in policy processes (Ostrom et al. 1994). In this sense they shape the ‘playing ﬁeld’ for political leaders, community actors and other participants. The institutional rules that set the arena both provide and restrict participants’ possibilities to interact. They provide the actors with a set of behavioural alternatives and thus shape (but do not determine) their actions.
Periodicity extraction for voiced sounds with multiple periodicity

A periodicity extraction method is introduced to analyze voiced sounds with a complex excitation behavior. Although general voiced sound has only one periodicity, some voiced sounds such as the pathological voice and the singing voice often have multiple periodicities. A method for estimating multiple periodicities from voiced sounds to deal with these kinds of voices is proposed in this article. At ﬁrst, a deﬁnition of the multiple periodicity and its causes are explained, and then the principle of the proposed method is introduced. The proposed method was evaluated by using several artiﬁcial signals and pathological voices recorded in a real environment. The analysis results from the artiﬁcial signals indicated that the proposed method can extract multiple periodicities, and that of the pathological voices shows a similar tendency. These results suggest that the proposed method is effective at extracting the multiple period-icities.
Developing leadership in higher education: perspectives from the USA, the UK and Australia

It is broadly acknowledged that leaders in the twenty-first century are required to navigate an increasingly complex landscape and that the types of challenges individuals and organisations face in the knowledge era require the capacity to adapt and respond to continual fluctuations and change. Outcomes from previous leadership research, combined with the perspectives of colleagues and observation over the past decade, prompted concern that leadership in higher education (HE) institutions was, in the main, not demonstrating the level of readiness or capability to effectively respond to the challenges embodied in the transition to the knowledge era. In seeking to establish how well founded this concern was, this study, supported by a Peter Karmel International Travel Grant, investigated leadership development thinking, programmes and practices within the HE sector in the United States of America and the United Kingdom, and explored how this applies within the Australian context. A number of themes emerged that support the idea that the work of leadership will ideally be based on relationships rather than the ‘command and control’ models of the past and on distributed leadership processes and practices throughout the organisation.
Monitoring the Hepatitis A Virus in Oyster from Korea

Hepatitis A virus (HAV) causes many cases of oyster- or clam-associated gastroenteritis in various countries. HAV was detected on oyster by RT-PCR in 19.6% (11/56) in Korea. The percentages of HAV-positive samples in 2011 and 2012 were 27.6% and 11.1%, respectively. Phylogenetic analysis revealed that several nucleotide sequences highly similar to those of HAVs isolated in this study. Phylogenetic analysis of the coding regions of the viral protein VP4/VP2 revealed that all amplicons were classified into IA genogroup. It will provide useful data that aids in our understanding circulating HAVs and may contribute to future control.
Long Memory in Stock Market Volatility and the Volatility-in-Mean Effect: The FIEGARCH-M Model

We extend the fractionally integrated exponential GARCH (FIEGARCH) model for daily stock return data with long memory in return volatility of Bollerslev and Mikkelsen (1996) by introducing a possible volatility-in-mean effect. To avoid that the long memory property of volatility carries over to returns, we consider a filtered FIEGARCH-in-mean (FIEGARCH-M) effect in the return equation. The filtering of the volatility-in-mean component thus allows the co-existence of long memory in volatility and short memory in returns. We present an application to the S&P 500 index which documents the empirical relevance of our model.
An Equilibrium Theory of the Distribution of Income and Intergenerational Mobility

The theory of inequality and intergenerational mobility presented in this essay assumes that each family maximizes a utility function spanning several generations. Utility depends on the consumption of parents and on the quantity and quality of their children. The income of children is raised when they receive more human and nonhuman capital from their parents. Their income is also raised by their "endowment" of genetically determined race, ability, and other characteristics, family reputation and "connections," and knowledge, skills, and goals provided by their family environment. The fortunes of children are linked to their parents not only through investments but also through these endowments acquired from parents (and other family members). The equilibrium income of children is determined by their market and endowed luck, the own income and endowment of parents, and the two parameters, the degree of inheritability and the propensity to invest in children. If these parameters are both less than unity, the distribution of income between families approaches a stationary distribution. The stationary coefficient of variation is greater, the larger the degree of in-heritability and the smaller the propensity to invest in children. Intergenerational mobility measures the effect of a family on the well-being of its children. We show that the family is more important when the degree of inheritability and the propensity to invest are larger. If both these parameters are less than unity, an increase in family income in one generation has negligible effects on the incomes of much later descendants. However, the incomes of children, grandchildren, and other early descendants could significantly increase; indeed, if the sum of these parameters exceeds unity, the changes in income rise for several generations before falling, and the maximum increase in income could exceed the initial increase.
Information: A critical factor in the process of performance appraisal

Performance appraisal plays an important role in many organizations, and how to improve its effectiveness is the major concern in the recent 50 years. Information is very useful in evaluating the performance of organizations or individuals while it is not noticed sufficiently in the literature In this paper, information has been identified as a determinant of accurate performance appraisal Comprehensive information enables accurate appraisal and the one who has information should be included and valued in the appraisal process. Customers, both internal and external, due to their enough information and powerful motivation, can enjoy a great consideration in the performance appraisal process.
How the West Was Won? The Dark Side of Institutional Entrepreneurship

Institutional entrepreneurs are often responsible for bringing practices to developing countries that, while novel for the latter, are highly institutionalized in the West. This cross-border diffusion often involves the exercise of power that while serving institutional entrepreneurs interests generates unintended consequences. Consideration of these unintended consequences illuminates power dynamics that led to them and thus extends our understanding of institutional entrepreneurship. Through a detailed study of the campaign to eliminate child labour in Pakistans soccer ball manufacturing industry, we identify how and why power was deployed and unintended consequences were produced. Our analysis problematizes the conventional understanding of institutional entrepreneurship and holds significant implications for future studies
Second‐order competences and Schumpeterian rents

Second-order competences, a type of dynamic capability, enable firms to engage in a process of Schumpeterian competition. This study examines the effects of marketing and R&D second-order competences (the abilities to create new market-related and technological resources) on firm profitability. Based on multiple informant surveys and archival data from U.S. public manufacturing firms, competitive turbulence is found to present contrasting contingencies for the effects of these competences on return on assets (ROA). The effect of marketing competence on ROA was positive under stable and moderate competitive conditions, whereas the effect of R&D competence on ROA was positive under volatile competitive conditions. Copyright © 2012 Strategic Management Society.
The need for effective biomedical imaging education.

There are several challenges to producing high-quality BMI education programs. These include limited opportunities for hands-on education; a dearth of textbooks targeted toward engineers, especially undergraduate engineers; and, like many fields, advancements so rapid that textbooks and other educational resources become out of date quickly, often before being released. Although there are many challenges to BMI education, there are many resources available that support its success. Many of these resources are Web based, including textbooks, tutorials, simulators, and teaching files. One online tutorial for ultrasound was shown to be as effective and more efficient than lectures in helping BME students learn the basics of ultrasound. Logical organization of imaging knowledge can be another learning resource by drawing out the parallels and hierarchy of concepts. Research on human learning and its implications for instruction, indicates that instruction designed around "anchored inquiry" of interesting challenges is particularly effective. Students' inquiry processes can be guided by an instructional sequence around a learning cycle called the "legacy cycle". Looking toward the future the trends indicate that demand for persons trained in BMI is increasing and can be expected to continue to increase in the foreseeable future. With increased demand for personnel and growing complexity of the field, the need for effective and efficient educational techniques will become more and more important. Online educational resources, allowing anytime/anywhere learning with the potential for educational interaction, will continue to grow in importance for BMI education. However, without a clear revenue model and with the volatility of the medium, it is uncertain that such online educational resources will ever attain the stature, prevalence, and continued utility of printed textbooks. Whatever the medium, hands-on learning exercises, simulators, and challenge-based learning should be included wherever possible to improve the effectiveness of BMI education.