Miracle-dz/UniFAR-FTUs huggingface dataset:
The Proportion of Mitochondrial Isoenzyme of Aspartate Aminotransferase Is Not Elevated in Reye's Syndrome

Summary: We reexamined a previously reported, highly specific increase in the relative proportion of the mitochondrial isoenzyme of asparate aminotransferase (AST) in the serum of patients with Reye's Syndrome. Using ion exchange chromatography, we measured mitochondrial, cytosolic, and total AST in serum samples from (1) 10 patients early in the course of Reye's Syndrome; (2) nine controls with normal serum AST; and (3) seven controls with other diseases causing an increase in serum AST. The mitochondrial percentage (2.8 ± 2.0%) in Reye's Syndrome was significantly lower (P < 0.05) than that of both the normal control group (6.1 ± 7.1%) and the group with increased AST (5.6 ± 4.0%). We thus failed to confirm the previous report of a specific increase in the % of mitochondrial isoenzyme in Reye's Syndrome, and conclude that the % of mitochondrial isoenzyme is not likely to be a useful marker of (or predictor for progression to) Reye's Syndrome.
Social and relational identification as determinants of care workers’ motivation and well-being

A growing body of research in the field of health and social care indicates that the quality of the relationship between the person giving care and the person receiving it contributes significantly to the motivation and well-being of both. This paper examines how care workers’ motivation is shaped by their social and relational identification at work. Survey findings at two time points (T1, N = 643; T2, N = 1274) show that care workers’ motivation increases to the extent that incentives, the working context (of residential vs. domiciliary care), and the professionalization process (of acquiring vs. not acquiring a qualification) serve to build and maintain meaningful identities within the organization. In this context care workers attach greatest importance to their relational identity with clients and the more they perceive this as congruent with their organizational identity the more motivated they are. Implications are discussed with regard to the need to develop and sustain a professional and compassionate workforce that is able to meet the needs of an aging society.
Antisense Oligonucleotide Inhibition of Bcl-xL and Bid Expression in Liver Regulates Responses in a Mouse Model of Fas-Induced Fulminant Hepatitis

Activation of the cell-surface receptor Fas can lead to apoptosis in parenchymal cells in the liver, and if severe enough, result in fulminant hepatic failure and animal death. In the present study, we have examined the roles played by the Bcl-2 family members Bcl-xL and Bid in regulating this response. To do this, we have developed chemically modified 2′-O-(2-methoxy) ethyl antisense inhibitors of both Bid and Bcl-xL expression. In Balb/c mice, dosing with these antisense oligonucleotides reduced expression of the targeted mRNA by greater than 80% in the liver. This reduction was highly dependent upon oligonucleotide sequence and oligonucleotide dose. Reduction of Bcl-xL expression resulted in a potentiation of Fas-mediated apoptosis in liver and significant increase of the lethality of Fas-mediated fulminant hepatitis (p < 0.0001). In contrast, reduction of Bid expression protected the animals against Fas-mediated fulminant hepatitis and death (p < 0.0001). Simultaneous dosing of mice with Bcl-xL and Bid-targeting antisense oligonucleotides resulted in an inhibition of expression of both targeted proteins and protection of the animals from Fas-mediated apoptosis. These results demonstrate, for the first time, the role of Bcl-xL in regulating responses to proapoptotic Fas signaling in mouse liver. In addition, this is the first reported example demonstrating the ability of antisense inhibitors to reduce expression of multiple proteins in animals by simultaneous dosing.
Grasp and tabu search for redesigning web communities

Web topologies are commonly characterised by hierarchical structures and highly unbalanced compositions, as illustrated by the difference of centrality and connectivity as to their elements. The major interest of the problem addressed in this paper lies in restructuring web communities to reduce these initial disequilibria so as to democratise information access or even for the purpose of preserving contents distributed on the Internet. Discussion of this issue thus leads to a hub location problem, formalised by network and integer programming models. Due to its highly complex nature, a GRASP and a tabu search heuristics were developed to find good quality feasible solutions to the problem. The set of test instances includes web communities obtained by crawling the web and using epistemic boundaries, as well as other randomly generated communities, built with specific network analysis software. The experiment demonstrated that the metaheuristics produced low costs and balanced structures, at least for the lower dimension web communities considered. All the redesigned web communities are more closely connected than before and the average distance among their elements reduced
A new adaptive long-term spectral estimation voice activity detector

This paper shows an efficient voice activity detector (VAD) that is based on the estimation of the long-term spectral diver- gence (LTSD) between noise and speech periods. The proposed method decomposes the input signal into overlapped speech frames, uses a sliding window to compute the long-term spec- tral envelope and measures the speech/non-speech LTSD, thus yielding a high discriminating decision rule and minimizing the average number of decision errors. In order to increase non- speech detection accuracy, the decision threshold is adapted to the measured noise energy while a controlled hang-over is ac- tivated only when the observed signal-to-noise ratio (SNR) is low. An exhaustive analysis of the proposed VAD is carried out using the AURORA TIdigits and SpeechDat-Car (SDC) databases. The proposed VAD is compared to the most com- monly used ones in the field in terms of speech/non-speech detection and recognition performance. Experimental results demonstrate a sustained advantage over G.729, AMR and AFE VADs.
MULTIVARIATE STABILIZING SELECTION AND PLEIOTROPY IN THE MAINTENANCE OF QUANTITATIVE GENETIC VARIATION

Abstract We investigate maintenance of quantitative genetic variation at mutation-selection balance for multiple traits. The intrinsic strength of real stabilizing selection on one of these traits denoted the “target trait” and the observed strength of apparent stabilizing selection on the target trait can be quite different: the latter, which is estimable, is much smaller (i.e., implying stronger selection) than the former. Distinguishing them may enable the mutation load to be relaxed when considering multivariate stabilizing selection. It is shown that both correlations among mutational effects and among strengths of real stabilizing selection on the traits are not important unless they are high. The analysis for independent situations thus provides a good approximation to the case where mutant and stabilizing selection effects are correlated. Multivariate stabilizing selection can be regarded as a combination of stabilizing selection on the target trait and the pleiotropic direct selection on fitness that is solely due to the effects of real stabilizing selection on the hidden traits. As the overall fitness approaches a constant value as the number of traits increases, multivariate stabilizing selection can maintain abundant genetic variance only under quite weak selection. The common observations of high polygenic variance and strong stabilizing selection thus imply that if the mutation-selection balance is the true mechanism of maintenance of genetic variation, the apparent stabilizing selection cannot arise solely by real stabilizing selection simultaneously on many metric traits.
Adaptive Iterative Learning Control for a Class of Nonlinear Systems with Unknown Control Directions

An adaptive iterative learning control(ILC) approach is proposed for a class of uncertain nonlinear systems without prior knowledge about system control directions. The Nussbaum-type gain and the positive definite discrete ma- trix kernel are proposed for dealing with selection of the unknown control gain and learning of the repeatable uncertain- ties, respectively. Asymptotic convergence for a trajectory tracking within a finite time interval is achieved through repeti- tive tracking. Simulations are carried out to show the validity of the proposed control method.
Ensemble‐based chemical data assimilation. II: Covariance localization

Data assimilation is the process of integrating observational data and model predictions to obtain an optimal representation of the state of the atmosphere. As more chemical observations in the troposphere are becoming available, chemical data assimilation is expected to play an essential role in air‐quality forecasting, similar to the role it has in numerical weather prediction. Considerable progress has been made recently in the development of variational tools for chemical data assimilation. In this paper we implement, and assess the performance of, a localized ‘perturbed‐observations’ ensemble Kalman filter (LEnKF). We analyse different settings of the ensemble localization, and investigate the joint assimilation of the state, emissions and boundary conditions. Results with a real model and real observations show that LEnKF is a promising approach for chemical data assimilation. The results also point to several issues on which future research is necessary. Copyright © 2007 Royal Meteorological Society
The use of prediction for accelerating upgrade misses in cc-NUMA multiprocessors

This work is focused on accelerating upgrade misses in cc-NUMA multiprocessors. These misses are caused by store instructions for which a read-only copy of the line is found in the L2 cache. Upgrade misses require a message sent from the missing node to the directory, a directory lookup in order to find the set of sharers, invalidation messages being sent to the sharers and responses to the invalidations being sent back. Therefore, the penalty paid by these misses is not negligible, mainly if we consider that they account for a high percentage of the total miss rate. We propose the use of prediction as a means of providing cc-NUMA multiprocessors with a more efficient support for upgrade misses by directly invalidating sharers from the missing node. Our proposal comprises an effective prediction scheme achieving high hit rates as well as a coherence protocol extended to support the use of prediction. Our work is motivated by two key observations: first, upgrade misses present a repetitive behavior and, second, the total number of sharers being invalidated is small (one, in some cases). Using execution-driven simulations, we show that the use of prediction can significantly accelerate upgrade misses (latency reductions of more than 40% in some cases). These important improvements translate into speed-ups on application performance up to 14%. Finally, these results can be obtained including a predictor with a total size of less than 48 KB in every node.
Picture scenarios for representing use context in design

The context of use has a major impact on mobile device design. However, there are few system design methods that assist user interface designers to represent use context in a useful and systematic manner throughout the design process. We report here on a method called Picture Scenarios that was used by four design teams whilst designing mobile information devices for a public square. Results show that Picture Scenarios helped the teams to better understand, negotiate and represent use context during their design activities.
Welfare benefits and work disincentives

Unemployment among people with mental health problems is disproportionately high. Despite this many wish to work. The welfare benefits system presents one of the most significant barriers to employment, training and study. This paper examines the financial implications of moving from welfare to work. Five case studies are presented and measures of welfare dependency are compared. The findings show that people with mental health problems face greater unemployment and poverty traps than the general population. It appears that there are few circumstances that would make a move into paid work financially viable. The recently introduced Disabled Persons' Tax Credit does little to improve this situation. Disincentives are created by complex, inflexible and arbitrary rules for disability and housing benefits. Further measures are required to promote the inclusion of people with mental health problems in the labour market.
Preventing Problem Behaviors: Primary, Secondary, and Tertiary Level Prevention Interventions for Young Children

The purpose of this report is to compare changes in social skills, problem behaviors, and academic competence for kindergarten or first grade students identified as being at risk for serious behavior problems who received primary, secondary, or tertiary level preventive interventions. Of the 93 participants in this study, 73% were male; 86% were Caucasian, and 65% were characterized as having externalizing behavior problems. A repeated measures analysis of variance indicated statistically significant differences (p < .01) between the groups based on type of intervention received the Self-Control subscale (e.g., controlling temper, responding appropriately to teasing) of the Social Skills Rating System (Gresham & Elliott, 1990). School-wide Positive Behavior Support is an effective primary prevention intervention, even for young children with serious internalizing or externalizing behavior problems.
PRESIDENTIAL SPEECHES AND TEACHING SOCIOLOGY (2009 MSSA PRESIDENTIAL ADDRESS)

In this address, I review available published presidential addresses written by presidents of various sociological organizations as a way of thinking about sociology and what sociologists may find important. Using Eller's categorizations, I divide the articles into three types including (1) query of the profession in which the author discussed the history of sociology or its future; (2) a call for new directions in methodologies or theories within sociology; and (3) a focus on the author/president's research. Then, I focus on what is missing in most presidential addresses given by sociologists: sociologists' role as educators and the impact we have upon students. I find that most presidential addresses do not include any or only passing nods to our responsibilities as teachers. I end the address with a call to consider our responsibilities and impact as teachers.
Behind the Mask: A Psychoanalytic Perspective on Interaction in the Design Studio

Abstract Design studio is routinely referred to as the center of architectural education, yet surprisingly little has been published about the nature of the interaction between instructors and students in the studio environment. This article draws upon ideas such as Donald Schön's description of design as “reflection-in-action” and D. W. Winnicott's discovery of the foundations of creativity in the “transitional phenomena” of early childhood to provide a basis for understanding the emotional power of the design studio experience and the ways in which phenomena identified by psychoanalysis can emerge in the interaction of studio instructors and students.
Heart rate recovery and methodological issues

1. Günaydın ZY, Gürel YE, Erdoğan G, Kaya A. Peripartum cardiomyopathy associated with triplet pregnancy. Anadolu Kardiyol Derg 2014; 14: 661-2. [CrossRef] 2. Rajab KE, Issa A. Peripartum Cardiomypathy. A five year hospital-based analytical study Bahrain Med Bull 2004; 26: 3. 3. Biteker M, Ilhan E, Biteker G, Duman D, Bozkurt B. Delayed recovery in peripartum cardiomyopathy: an indication for long-term follow-up and sustained therapy. Eur J Heart Fail 2012; 14: 895-901. [CrossRef] 4. Michael M. Givertz. Peripartum Cardiomyopathy Circulation 2013; 127: 622-6. [CrossRef] 5. Garg J, Palaniswamy C, Lanier G. Peripartum Cardiomyopathy: Definition, Incidence, Etiopathogenesis, Diagnosis and Management. Cardiol Rev 2014 Aug 8. Epub ahead of print. [CrossRef]
Normative Topographic ERP Analyses of Speed of Speech Processing and Grammar Before and After Grammatical Treatment

Typically developing (TD) preschoolers and age-matched preschoolers with specific language impairment (SLI) received event-related potentials (ERPs) to four monosyllabic speech sounds prior to treatment and, in the SLI group, after 6 months of grammatical treatment. Before treatment, the TD group processed speech sounds faster than the SLI group. The SLI group increased the speed of their speech processing after treatment. Posttreatment speed of speech processing predicted later impairment in comprehending phrase elaboration in the SLI group. During the treatment phase, change in speed of speech processing predicted growth rate of grammar in the SLI group.
Schema matching over relations, attributes, and data values

Automatic schema matching algorithms are typically only concerned with finding attribute correspondences. However, real world data integration problems often require matchings whose arguments span all three types of elements in relational databases: relation, attribute and data value. This paper introduces the definitions and semantics of three additional correspondence types concerning both schema and data values. These correspondences cover the higher-order mappings identified in a seminal paper by Krishnamurthy, Litwin, and Kent. It is shown that these correspondences can be automatically translated to tuple generating dependencies (tgds), and thus this research is compatible with data integration applications that leverage tgds. Two methods for automatically identifying these correspondences are developed. One requires a limited number of duplicates across data sources. The other is a general instance-based method with no such requirement. Experiments conducted on four real world data sets demonstrate the effectiveness of the methods.
Jewish Thought and Scientific Discovery in Early Modern Europe

This book is a sally into the scientific dimension of Jewish intellectual history in the early modern world, dealing with many key personalities and topics in a novel way. Included are thumbnail sketches of stoicism, iatrochemistry and pantheism, in addition to reviews of the major issues in the Jewish historiography of the period. It offers comprehensive treatment of the impact of the scientific revolution on Jewish culture in early modern Europe and should be of value not only to students of Jewish intellectual history of this period, but also more generally to anyone interested in European cultural history or the history of medicine.
Implicit Theories and Their Role in Judgments and Reactions: A Word From Two Perspectives

In this target article, we present evidence for a new model of individual differences in judgments and reactions. The model holds that people's implicit theories about human attributes structure the way they understand and react to human actions and outcomes. We review research showing that when people believe that attributes (such as intelligence or moral character) are fixed, trait-like entities (an entity theory), they tend to understand outcomes and actions in terms of these fixed traits ("I failed the test because I am dumb" or "He stole the bread because he is dishonest"). In contrast, when people believe that attributes are more dynamic, malleable, and developable (an incremental theory), they tend to focus less on broad traits and, instead, tend to understand outcomes and actions in terms of more specific behavioral or psychological mediators ("I failed the test because of my effort or strategy" or "He stole the bread because he was desperate"). The two frameworks also appear to foster different r.
Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages

Macrophages are critical effectors of the early innate response to bacteria in tissues. Phagocytosis and killing of bacteria are interrelated functions essential for bacterial clearance but the rate‐limiting step when macrophages are challenged with large numbers of the major medical pathogen Staphylococcus aureus is unknown. We show that macrophages have a finite capacity for intracellular killing and fail to match sustained phagocytosis with sustained microbial killing when exposed to large inocula of S. aureus (Newman, SH1000 and USA300 strains). S. aureus ingestion by macrophages is associated with a rapid decline in bacterial viability immediately after phagocytosis. However, not all bacteria are killed in the phagolysosome, and we demonstrate reduced acidification of the phagolysosome, associated with failure of phagolysosomal maturation and reduced activation of cathepsin D. This results in accumulation of viable intracellular bacteria in macrophages. We show macrophages fail to engage apoptosis‐associated bacterial killing. Ultittop mately macrophages with viable bacteria undergo cell lysis, and viable bacteria are released and can be internalized by other macrophages. We show that cycles of lysis and reuptake maintain a pool of viable intracellular bacteria over time when killing is overwhelmed and demonstrate intracellular persistence in alveolar macrophages in the lungs in a murine model.
The practice of socialization and the socialization of practice

At the core of how societies operate, lies social interaction. Organizations as significant social bodies rely on social interaction both to get things done in order to remain sustainable and also impart a contribution to the wider society. Understanding the dynamics of social interactions in the way social agents and social action take place through the lens of social practice theory could yield powerful insights both about practices of socialization as well as the socialization of practices. The purpose of this paper is to fundamentally reveal the tensions that such interaction expose and the dynamics in negociating individual and collective priorities