Miracle-dz/UniFAR-FTUs huggingface dataset:
Structural Ceramic Components by 3D Printing

The Three Dimensional Printing (3DP) Process hasbe~nadapted for processing of fine ceramic powders to •• prepare structllraLceramic components. Our preliminary study was designed to reveal those aspects ofthe.3DPprocesswhichmust be modified for use with fine ceramic powders. The basic elements of the modified process are to spread submicron alumina powder and printJatex binder. Several methods were used to spread thin layers of submicron powders. Gre.enparts are isostaticaUypressed followed by thermal decomposition prior to sintering to remove the polymer. The fired alumina components are greater than 99.2% dense and have·average flexural strength of324 MPa. This is lower than the best conventionally prepared alumina, but we believe that the strength results will improve as we learn more about the relationship between strength limiting flaws and the 3DP build process.
Comparison of the patterns of milk ejection during repeated breast expression sessions in women.

BACKGROUND This study aimed to investigate the consistency of milk ejections and milk expression characteristics within mothers at repeated expression sessions. METHODS Twenty-five breastfeeding mothers expressed their breasts simultaneously on three occasions within 3 weeks, and follow-up visits were performed at 6, 9, and 12 months of lactation. During the 15-minute expression, milk was collected onto a continuous weigh balance to measure milk flow rate. RESULTS The number of milk ejections was similar at the three sessions (5.1±2.0), decreasing at the 12-month follow-up (3.3±1.2). Mothers had a similar pattern of milk ejection at each session. The time that each milk ejection occurred was consistent for the first 9 months of lactation. Of the four milk ejection patterns identified, each removed a similar percentage of available milk but varied in the time to reach 80% of the total expression volume. The first two milk ejections produced the greatest percentage (62%) of total milk volume during breast expression. CONCLUSIONS For each individual mother, the timing, pattern, and number of milk ejections were consistent, suggesting a predetermined release of oxytocin. In light of the innate oxytocin release and milk removal characteristics in women, there is potential for individual tailoring of the duration of expression.
Liver Histology in Pediatric NAFLD HOW SAFE IS LIVER BIOPSY AS A TEST FOR NAFLD IN CHILDREN ?

The importance of nonalcoholic steatohepatitis (NASH) was first recognized formally at a National Institutes of Health Consensus Symposium in December 1998. Since then, there has been a rapid growth of knowledge regarding nonalcoholic fatty liver disease (NAFLD) in children. The greatest advances have been made in the realms of awareness, diagnosis, and understanding of associated comorbidities. Challenges that lie ahead are centered on clinical management—the ongoing search for valid noninvasive diagnostic tools and effective therapy. This review addresses key clinical questions for which progress has been made.
Successful Resuscitation of a Patient with Life-Threatening Metabolic Acidosis by Hemodialysis: A Case of Ethylene Glycol Intoxication

Background Ethylene glycol intoxication causes severe metabolic acidosis and acute kidney injury. Fomepizole has become available as its antidote. Nevertheless, a prompt diagnosis is not easy because patients are often unconscious. Here we present a case of ethylene glycol intoxication who successfully recovered with prompt hemodialysis. Case Presentation A 52-year-old Japanese male was admitted to a local hospital due to suspected food poisoning. The patient presented with nausea and vomiting, but his condition rapidly deteriorated, with worsening conscious level, respiratory distress requiring mechanical ventilation, hypotension, and severe acute kidney injury. He was transferred to the university hospital; hemodialysis was initiated because of hyperkalemia and severe metabolic acidosis. On recovering consciousness, he admitted having ingested antifreeze solution. Thirty-seven days after admission, the patient was discharged without requiring HD. Conclusions We reported a case of ethylene glycol intoxication who presented with a life-threatening metabolic acidosis. In a state of severe circulatory shock requiring catecholamines, hemodialysis should be avoided, and continuous hemodiafiltration may be a preferred approach. However, one should be aware of the possibility of intoxication by unknown causes, and hemodialysis could be life-saving with its superior ability to remove toxic materials in such cases.
Business models for eGovernment services

Public sector information furnishes a valuable information resource for many businesses. Thus, the design of value chains across different stakeholders and corresponding business models capitalising on public sector information is a challenge. Business models have been investigated mostly in the realms of eCommerce and rarely for public private partnerships. Thus, they are strongly tailored to financial incentives. So far, the modelling of policies and arguments have been neglected in eCommerce approaches. This paper describes a new modelling method named BMeG (Business Models for eGovernment) supporting the planning of business models for eGovernment services. BMeG facilitates the modelling of options of value chains with public and private partners, their relationships with individual advantages and disadvantages for policies. Hence, BMeG unveils business opportunities and their rationales.
Antitumor activity of crude extract and fractions from root tuber of Cynanchum auriculatum Royle ex Wight

Antitumor activity of the ethanol extract from the root tuber of Cynanchum auriculatum Royle ex Wight and four fractions of the ethanol extract were investigated, both in vitro and in vivo. The five samples exhibited cytotoxic activity on human tumor cell lines K562, SHG44, HCT‐8, A549, PC3, in vitro and inhibition in mouse implanted sarcoma S180, in vivo. Among the five samples, fraction E was noted to be of the highest antitumor activity. Copyright © 2005 John Wiley & Sons, Ltd.
Are XORs in logic synthesis really necessary?

This paper follows recent research on insufficient synthesis performance for XOR-intensive circuits, and introduces a novel logic representation with a native support of XOR gates, the XOR-AND-Inverter Graphs (XAIGs). A rewriting algorithm over XAIG has been implemented in the logic synthesis and optimization package ABC, as the first step towards a complete synthesis process. The results show that XAIG based rewriting can help to discover XORs and improves the area of a mapped network in some cases.
Evaluation of an audiovisual-FM system: Speechreading performance as a function of distance

A research program was undertaken to evaluate the efficacy of an audiovisual-FM system as a speechreading aid. The present study investigated the effects of the distance between the talker and the speechreader on a visual-speech perception task. Sentences were recorded simultaneously with a conventional Hi8 mm video camera, and with the microcamera of an audiovisual-FM system. The recordings were obtained from two talkers at three different distances: 1.83 m, 3.66 m, and 7.32 m. Sixteen subjects completed a visual-keyword recognition task. The main results of the investigation were as follows: For the recordings obtained with the conventional video camera, there was a significant decrease in speechreading performance as the distance between the talker and the camera increased. For the recordings obtained with the microcamera of the audiovisual-FM system, there were no differences in speechreading as a function of the test distances.The findings of the investigation confirm that in a classroom setting the use of an audiovisual-FM system may constitute an effective way of overcoming the deleterious effects of distance on speechreading performance.
Driving the Gaseous Evolution of Massive Galaxies in the Early Universe

Studies of the molecular interstellar medium that fuels star formation and supermassive black hole growth in galaxies at cosmological distances have undergone tremendous progress over the past few years. Based on the detection of molecular gas in >120 galaxies at z=1 to 6.4, we have obtained detailed insight on how the amount and physical properties of this material in a galaxy are connected to its current star formation rate over a range of galaxy populations. Studies of the gas dynamics and morphology at high spatial resolution allow us to distinguish between gas-rich mergers in different stages along the "merger sequence" and disk galaxies. Observations of the most massive gas-rich starburst galaxies out to z>5 provide insight into the role of cosmic environment for the early growth of present-day massive spheroidal galaxies. Large-area submillimeter surveys have revealed a rare population of extremely far-infrared-luminous gas-rich high-redshift objects, which is dominated by strongly lensed, massive starburst galaxies. These discoveries have greatly improved our understanding of the role of molecular gas in the evolution of massive galaxies through cosmic time.
Isolation and characterization of 17 microsatellite loci for the Chinese longsnout catfish (Leiocassis longirostris)

We describe the isolation and development of 17 polymorphic dinucleotide microsatellite loci for the Chinese longsnout catfish (Leiocassis longirostris). All loci were polymorphic in the 30 individuals tested. The number of alleles per variable locus ranged from 6 to 18, with a mean of 11.71. Observed and expected heterozygosities ranged from 0.467 to 1.000 and from 0.540 to 0.929, respectively. Eight loci were found to have deviated from HWE in the sampled population after Bonferroni correction. Linkage disequilibrium tests revealed significant linkage between two loci (LLW5 and LL27). These microsatellite loci will be useful for revealing population structure, genetic diversity, and phylogeography of the Chinese longsnout catfish.
Experimental Evaluations of Printed Circuit Board and On-Chip Inductors Backed by AMC Surfaces

This letter investigates the role of artificial magnetic conductor (AMC) surfaces in increasing the inductance of printed inductors. Both printed circuit board (PCB) and on-chip loop inductor prototypes backed by spiral AMC surfaces are designed and fabricated for this purpose. Measurements of PCB prototypes demonstrate that the loop inductance increases by a factor of 2 or higher within the AMC operation bands. Furthermore, experimental evaluations of the developed test-chips prove successful miniaturization of a loop inductor when the AMC reflector is employed. The drawback of this technique is degradation of the quality factor near the AMC operation regions, which is shown to be caused by the generation of eddy currents in the spiral conductor paths of the AMC surface.
Variants, haplotypes and htSNPs of UDP-glucuronosyltransferase 1A9, 1A7 and 1A1 genes in Chinese Tibetan Population

No data about the genetic information of UGT1A9, 1A7, 1A1 loci in Tibetan population were available up to now. In the present study, we systematically studied the polymorphisms of promoters, exon 1 of the UGT1A9, 1A7, 1A1 gene and common exons 2-5 in 100 unrelated healthy Chinese Tibetan subjects, using direct sequencing. A total of 36 variants, including eight novel ones were detected in our study. Four, five and six alleles and seven, eight and nine genotypes were detected in UGT1A9, 1A7 and 1A1, respectively. Two LD blocks were calculated; eight common haplotypes were identified for block 1 (account for 98.1% of UGT1A7 haplotype diversity) and three common haplotypes (account for 99.5% of exons 2-5 haplotype diversity) for block 2. The htSNPs were selected based on haplotype measure. The present knowledge of UGT haplotypes and htSNPs can improve understanding of genetic risk factors and increase the safety and efficiency of individualization of drug dosage while avoiding intoxication by studying drug response and developing the targeted drug therapy for individual patients in Chinese Tibetan.
Differentiating COPD From Asthma in Clinical Practice

It has been recognized that features of chronic obstructive pulmonary disease (COPD) and asthma overlap, often rendering a firm diagnosis difficult to achieve for the clinical practitioner. There are hypotheses suggesting that both asthma and COPD may indeed share common origins with differences in phenotypic presentation being related to disease evolution or interaction between endogenous and exogenous factors. Others suggest that the two conditions are clinically and pathophysiologically distinct. Studies of the underlying inflammation demonstrate a difference in the preponderance of inflammatory cells and mediators in each disease, yet many shared characteristics in the inflammatory process can be found when examining the two conditions. Generally, later age of presentation favors a diagnosis of COPD; fully reversible airflow limitation on pulmonary function testing suggests a diagnosis of asthma; hyperinflation at rest makes a diagnosis of COPD likely; impaired diffusing capacity is associated with COPD whereas these measurements in patients suffering from asthma are usually normal or even elevated; reduced elastic recoil is the hallmark of COPD, particularly those who pathophysiologically demonstrate abnormal enlargement of air spaces with wall destruction seen in emphysema; and finally history of atopy favors a diagnosis of asthma, particularly if presenting at a younger age. This review reflects discussion of the differences and similarities in diagnosis and treatment.
A low-power ESD-protected 24GHz receiver front-end with π-type input matching network

This paper presents a full ESD-protected receiver front-end for wireless communications around 24GHz, comprising LNA, mixer, VGA, and on-chip balun. A π-type input matching network incorporating ESD capacitance is constructed to realize the source impedance transformation for higher gain. With it, the gain of the first stage is improved while the noise figure is just degraded slightly. The measured results show an input return loss of less than −12dB, 36dB voltage gain, 6.9dB noise figure, and 2dBm output P1dB. The chip has an HBM ESD robustness of ±2kV and consumes 34mA from a 1.2V supply with a total area of 1×0.8 mm2 using 0. 13µm RF CMOS process.
Intérêt de la PCR dans le diagnostic de l'aspergillose invasive chez les patients immunodéprimés

Depuis la fin des annees 1990, des techniques de biologie moleculaire ont ete developpees afin d'ameliorer le diagnostic de l'aspergillose invasive chez les patients immunodeprimes. Nous avons passe enrevue les differentes techniques evaluees, avec leurs contraintes, leurs avantages et leurs inconvenients. Les resultats obtenus montrent qu'il n 'existe pas actuellement de technique de reference suffisamment performante pour l'utilisation diagnostique en routine au laboratoire. Cependant, la mise au point de techniques de PCR en temps reel, methodologie fiable et rapide, associee aux techniques d'extraction automatisees, va probablement permettre d'optimiser la sensibilite et la specificite de ces tests.
Cyber Security of FPGA-Based NPP I & C Systems : Challenges and Solutions

This paper presents an overview of the state-of-the-art of Field Programmable Gate Arrays(FPGA)-based Nuclear Power Plants (NPPs) Instrumentation and Control (I&C) systems cyber security assurance problem, starting from analysis of regulatory documents that cover various aspects of NPP I&C systems development and operation, FPGA technology implementation, as well as cyber security assessment and assurance in context of safety as a whole to reveal the most significant problems. Then, the paper briefly describes processand productoriented approach to analysis of FPGAbased NPP I&C system cyber security. Besides, the paper proposes a technique for cyber security assessment, which covers FPGA-based NPP I&C systems life cycle processes, products, and appropriate requirements. The proposed technique is based on Gap Analysis (GA) and Intrusion Modes and Effects Criticality Analysis (IMECA) procedures, and is applicable to complex I&C systems, including safety-critical FPGA-based I&C systems. Elements of GA-and-IMECA procedure of assessment are described. As an example, the proposed approach and technique are illustrated via some results of cyber security assessment for NPP I&C systems developed on the basis of the FPGA-based platform RadICS (Research and Production Corporation Radiy).
Lean Supply Chain Planning: A Performance Evaluation through Simulation

Nowadays companies look more and more for improving their efficiency to excel in the market. At the same time, the competition has moved from firm level to whole supply chain level. Supply chain are very complex systems and lacks of coordination among their members leads to inefficiency. Supply chain planning task is to improve coordination among supply chain members. Which is the best planning solution to improve efficiency is an open issue. On the other hand, Lean approach is becoming more and more popular among managers. Lean approach is recognize as efficiency engine for production systems, but effects of Lean implementation out of single firm boundaries is not clear. This paper aims at providing a theoretical and practical starting point for Lean implementation in supply chain planning issue. To reach it, a DES simulation model of a three-echelon and multi-product supply chain has been set. Lean management is a very broad topic and this paper focuses on two principles of “pull” and “create the flow”. Kanban system and setup-time and batch-size reductions are implemented in the lean-configured supply chain to apply “pull” and “create the flow” respectively. Lean principles implementations have been analyzed and compared with other supply chain planning policies: EOQ and information sharing (Visibility). Supported by the simulation study, this paper points Lean supply chain planning is a competitive planning policies to increase efficiency.
Targeting HER2 Aberrations in Non–Small Cell Lung Cancer with Osimertinib

Purpose: HER2 (or ERBB2) aberrations, including both amplification and mutations, have been classified as oncogenic drivers that contribute to 2% to 6% of lung adenocarcinomas. HER2 amplification is also an important mechanism for acquired resistance to EGFR tyrosine kinase inhibitors (TKI). However, due to limited preclinical studies and clinical trials, currently there is still no available standard of care for lung cancer patients with HER2 aberrations. To fulfill the clinical need for targeting HER2 in patients with non–small cell lung cancer (NSCLC), we performed a comprehensive preclinical study to evaluate the efficacy of a third-generation TKI, osimertinib (AZD9291). Experimental Design: Three genetically modified mouse models (GEMM) mimicking individual HER2 alterations in NSCLC were generated, and osimertinib was tested for its efficacy against these HER2 aberrations in vivo. Results: Osimertinib treatment showed robust efficacy in HER2wt overexpression and EGFR del19/HER2 models, but not in HER2 exon 20 insertion tumors. Interestingly, we further identified that combined treatment with osimertinib and the BET inhibitor JQ1 significantly increased the response rate in HER2-mutant NSCLC, whereas JQ1 single treatment did not show efficacy. Conclusions: Overall, our data indicated robust antitumor efficacy of osimertinib against multiple HER2 aberrations in lung cancer, either as a single agent or in combination with JQ1. Our study provides a strong rationale for future clinical trials using osimertinib either alone or in combination with epigenetic drugs to target aberrant HER2 in patients with NSCLC. Clin Cancer Res; 24(11); 2594–604. ©2018 AACR. See related commentary by Cappuzzo and Landi, p. 2470
Is autonomous motivation the key to maintaining an active lifestyle in first‐episode psychosis?

Physical activity has the potential to improve the health of patients with first‐episode psychosis (FEP), yet many patients with FEP remain inactive. Exploring the theoretical basis of the motivational processes linked to the adoption and maintenance of physical activity behaviours in FEP patients can assist with the design and delivery of physical activity interventions. Within the self‐determination theory and the transtheoretical model (stages of change) frameworks, we investigated motives for physical activity adoption and maintenance in FEP.
HUANG, Po-Han, Poster

constraints may include as a cluster head a small cell that wouldn’t be picked by the optimal algorithm. Note that with coverage constraints the system is forced to select some remote cells to be cluster heads to relay traffic from remote cells to the macro cell, leading to faster system throughput saturation. Last, Fig. 3c plots the capacity of the backhaul links between cluster heads and the macro cell, as well as the proportion of small cells that are selected as cluster heads, as the number of small cells increase for a varying number of macro cell antennas. In contrast to Fig. 2c, coverage constraints cause the backhaul link capacities to decrease as the number of small cells increase, since a growing number of remote cluster heads are used to service remote small cells, and remote cluster heads require more antennas to achieve the same backhaul rates as cluster heads which are located closer to the macro cell. Also, like in Fig. 2c, the fraction of small cells which are cluster heads goes down since small cells increase but the number of cluster heads is bounded by the number of antennas. 3) Effect of the Number of Small Cells in Large-scale Scenario: We conduct large-scale experiments with 1001000 small cells, 200-1000 antennas at the macro cell, and 500m/200m radius for the macro/small cells respectively. Fig. 4a plots the capacity of the backhaul links between cluster heads and the macro cell, as well as the proportion of small cells that are selected as cluster heads, as the number of small cells increase for a varying number of macro cell antennas. The coverage constraints again force the system to select cluster heads which are relatively far from the macro cell such that traffic from remote small cells is relayed, resulting in a smaller backhaul link capacity as the number of small cells increases. Interestingly there is a local rebound on the link capacity before it goes down again. This happens when the number of cells are a bit larger than the number of antennas, because while the number of clusters heads can’t be increased further, new cluster heads can be selected which are closer to the macro cell achieving higher link rates with the same number of antennas. Like before the number of cluster heads saturates due to antenna constraints and as the number of small cells keeps on increases the portion of small cells which are cluster heads goes down.
Unified Interactive Wavelet Approach for 2D Sketch Segmentation and Editing

Style sketches are an essential tool for the expression and the definition of the shape of industrial products. We present a novel wavelet approach for sketch segmentation and editing expressly addressed to the designer needs. Starting from a 2D curve drawn by a user with a graphics tablet, our algorithm converts it in a B-spline representation, detects the style features, allows interactive smoothing and continuous local and global editing. The novelty compared to the existing literature is the combination of: (i) unified wavelet approach to segmentation, smoothing and editing, (ii) support for endpoint C0 and C1 continuity constraints and (iii) implementation with an interactive pen-tablet interface. Our approach requires low memory footprints with time complexity linear in the number of control points. We validated the algorithm with synthetic and practical tests.