Miracle-dz/UniFAR-FTUs huggingface dataset:
Human satellite-III non-coding RNAs modulate heat-shock-induced transcriptional repression

ABSTRACT The heat shock response is a conserved defense mechanism that protects cells from physiological stress, including thermal stress. Besides the activation of heat-shock-protein genes, the heat shock response is also known to bring about global suppression of transcription; however, the mechanism by which this occurs is poorly understood. One of the intriguing aspects of the heat shock response in human cells is the transcription of satellite-III (Sat3) long non-coding RNAs and their association with nuclear stress bodies (nSBs) of unknown function. Besides association with the Sat3 transcript, the nSBs are also known to recruit the transcription factors HSF1 and CREBBP, and several RNA-binding proteins, including the splicing factor SRSF1. We demonstrate here that the recruitment of CREBBP and SRSF1 to nSBs is Sat3-dependent, and that loss of Sat3 transcripts relieves the heat-shock-induced transcriptional repression of a few target genes. Conversely, forced expression of Sat3 transcripts results in the formation of nSBs and transcriptional repression even without a heat shock. Our results thus provide a novel insight into the regulatory role for the Sat3 transcripts in heat-shock-dependent transcriptional repression. Highlighted Article: The satellite-III non-coding RNAs, expressed only during heat shock in human cells, recruit transcription factors to their nuclear foci, contributing to heat-shock-induced transcriptional repression.
Explicit Constructions for Type-1 QC-LDPC Codes With Girth 12

Given any <inline-formula> <tex-math notation="LaTeX">$J\times J\,\,(J>3)$ </tex-math></inline-formula> square matrix over <inline-formula> <tex-math notation="LaTeX">$\textbf {Z}_{P}$ </tex-math></inline-formula> such that the differences of any two row vectors contain each element in <inline-formula> <tex-math notation="LaTeX">$\textbf {Z}_{P}$ </tex-math></inline-formula> at most once, a class of <inline-formula> <tex-math notation="LaTeX">$(3,L)$ </tex-math></inline-formula>-regular quasi-cyclic low-density parity-check codes is explicitly constructed with lengths <inline-formula> <tex-math notation="LaTeX">$PJL^{2}$ </tex-math></inline-formula> and girth 12, where <inline-formula> <tex-math notation="LaTeX">$L$ </tex-math></inline-formula> is any integer satisfying <inline-formula> <tex-math notation="LaTeX">$3<L\leq J$ </tex-math></inline-formula>. Simulation results show that the new codes perform very well for moderate rates and lengths.
Design Envelopes and Optical Feature Extraction Techniques for Survivability of SnAg Lead-free Packaging Architectures Under Shock and Vibration

In this paper, a design-envelope approach based on optical feature extraction techniques has been investigated for drop and shock survivability of electronic packaging has been presented for 6-lead-free solder alloy systems. Solder alloy systems investigated include, Sn1Ag0.5Cu, Sn3Ag0.5Cu, Sn0.3Ag0. 7Cu, Sn0.3Ag0. 7Cu0.1Bi, Sn0.2Ag0. 7Cu0.1Bi-0.1Ni, 96.5Sn 3.5Ag. Previously, digital image correlation (DIC) has been used for measurement of thermally induced deformation and material-characterization. In this paper, DIC has been used for transient dynamic measurements, and optical feature extraction. Board assemblies have been subjected to shock-impact in various orientations including the JEDEC zero-degree drop and the vertical free-drop. Transient deformation has been measured using both digital image correlation and the strain gages. Measurements have been taken on both the package and the board side of the assemblies. Accuracy of high-speed optical measurement has been compared with that from discrete strain gages. Package architectures examined include-flex ball-grid arrays, tape-array ball-grid arrays, and metal lead-frame packages. Explicit finite-element models have been developed and correlated with experimental data. Models developed include, smeared property models, and Timoshenko-beam models. The potential of damage identification and tracking for various solder alloys has been investigated. Data on identification of damage proxies for competing failure mechanisms at the copper-to-solder, solder-to-printed circuit board, and copper-to-package substrate has been presented. Design envelopes have been developed based on statistical pattern recognition. The design-envelope is intended for component integration to ensure survivability in shock and vibration environments at a user-specified confidence level.
Network-Adaptive Scheduling of Data-Intensive Parallel Jobs with Dependencies in Clusters

The performance of data-intensive parallel jobs is often constrained by the cluster's hard-to-scale network bisection bandwidth. Previous solutions do not consider inter-job data dependencies and schedule jobs independently from one another. In this work, we find that aggregating and co-locating the data and tasks of dependent jobs offers an extra opportunity of data locality that can help to greatly enhance the performance of clusters and jobs. We propose and design Dawn, a network-adaptive scheduler that includes an online plan and an adaptive task scheduler for jobs with dependencies. The online plan, taking job dependencies into consideration, determines preferred locations (e.g., racks) for tasks to proactively aggregate dependent data. The task scheduler, based on the output of online plan and dynamic network bandwidth status, adaptively schedule tasks to co-locate with the dependent data in order to take advantage of data locality. We implement Dawn on Apache Yarn and evaluate it on clusters using various benchmark workloads. Results show that Dawn effectively improves system throughput by 42-51% and 21-28% compared to Fair Scheduler and ShuffleWatcher, respectively.
Development of a novel ODEP chip using polymer photoconductive material and FTO electrode

A novel ODEP (optical dielectrophoresis) chip using a polymer photoconductive material and fluorine doped tin oxide (FTO) conductive film is demonstrated to manipulate micron-sized polystyrene beads. Instead of using the traditional hydrogenated amorphous silicon (a-Si:H) as photoconductive layers, a thin film of a mixture of poly (3-hexylthiophene) (P3HT) and [6,6]-phenyl C61-butyric acid methylester (PCBM) photoconductive polymer is used in this novel ODEP chip. When the polymer layer is illuminated by a light beam, many electron-hole pairs are created, which increase the conductivity of the polymer. Consequently, localized non-uniform electric field can be generated when an AC bias is applied across the ODEP chip, and localized DEP forces are then generated. The distribution of electrical field induced by a ring-shaped optical electrode is simulated and the maximum trapping velocity is calculated according to Stokes' law for this ODEP chip. The effect of the polymer thickness to the magnitude of the generated DEP force has also been investigated. The maximum trapping velocity and the induced DEP force exerted on 20 µm polystyrene beads are estimated to be 77 µm/s and 15 pN, respectively. Finally, performance of the polymer-based ODEP chip is compared with an a-Si:H-based ODEP chip by trapping and sorting polystyrene beads with identical parameters. The experimental results indicate that the polymer photoconductive material used in our work is promising for rapid fabrication of ODEP chips for microparticles manipulation.
INFLUENCE OF AGRICULTURAL TRADE LIBERALIZATION POLICIES ON POVERTY REDUCTION AMONG GHANAIA N RURAL SMALLHOLDER RICE FARMERS

AnAng, S. A. and T. YAnwen, 2014. Influence of Agricultural trade liberalization policies on poverty reduction among Ghanaian rural smallholder rice farmers. Bulg. J. Agric. Sci., 20: 746-753 The objective of the study was to assess the influence of Agricultural trade liberalization policies on production and poverty reduction among rural smallholder rice farmers in Ghana. The study areas were chosen due to the intense cultivation of rice and the presence of a large number of smallholder farmers in those areas. Both cross-sectional and secondary data were used in the study. One hundred (100) respondents were sampled from six (6) districts across the six agro-ecological zones in the country using the simple random sampling technique across the study districts and structured questionnaire was administered to them. Data analyses involved the use of multiple regression and logistic or logit regression. Descriptive statistics was also employed to summarize the data. The study indicated that, government’s investment in the agricultural sector and the total land area cultivated of rice significantly influence positively the gross output of rice production while total imports of rice significantly influence negatively the gross output of rice. Again, provision of extension services, input services, market services, and the size of land cultivated and import tariffs showed a higher likelihood of enhancing increase in rice production. Imports of rice were likely to significantly and negatively reduce increase in rice production. The study also found that agricultural trade liberalization policies have generally contributed to the increase in income levels of the farmers. The study concluded that Agricultural trade liberalization policies adopted by Ghana in the early 1980s generally have had both positive and negative effects on the production of rice over the years looking at the production trend of rice but has contributed to the increase in incomes of the farmers hence contributed to poverty reduction.
Towards Full Text Shallow Discourse Relation Annotation: Experiments with Cross-Paragraph Implicit Relations in the PDTB

Full text discourse parsing relies on texts comprehensively annotated with discourse relations. To this end, we address a significant gap in the inter-sentential discourse relations annotated in the Penn Discourse Treebank (PDTB), namely the class of cross-paragraph implicit relations, which account for 30% of inter-sentential relations in the corpus. We present our annotation study to explore the incidence rate of adjacent vs. non-adjacent implicit relations in cross-paragraph contexts, and the relative degree of difficulty in annotating them. Our experiments show a high incidence of non-adjacent relations that are difficult to annotate reliably, suggesting the practicality of backing off from their annotation to reduce noise for corpus-based studies. Our resulting guidelines follow the PDTB adjacency constraint for implicits while employing an underspecified representation of non-adjacent implicits, and yield 62% inter-annotator agreement on this task.
Different cytokines regulate antigen uptake and presentation of a precursor dendritic cell line

Langerhans cells (LC) and dendritic cells (DC) need to be activated in order to perform their antigen‐presenting function. In this study, we explored the influence of cytokines on the uptake and presentation of protein antigens by the retrovirally immortalized myeloid cell line FSDC. This cell line was generated from mouse fetal skin and was previously shown to have the characteristics of early DC precursors. Both FSDC and bone marrow‐derived DC (BM‐DC) were more effective in the pinocytosis of FITC‐conjugated ovalbumin (FITC‐OVA) and dextran (FITC‐DX) than B cells or macrophages. Pretreatment of FSDC with granulocyte/macrophage colony‐stimulating factor (GM‐CSF) ± interleukin (IL)‐4 enhanced the pinocytic uptake of FITC‐OVA and FITC‐DX, but did not induce antigen‐presenting capacity. In contrast, untreated FSDC or FSDC pre‐incubated with GM‐CSF ± IL‐4 suppressed T cell responses. Treatment of FSDC with IFN‐γ reduced pinocytosis but increased the expression of MHC and co‐stimulatory/adhesion molecules and promoted efficient presentation of OVA protein or peptide to the specific DO11.10 T cell hybridoma or to naive CD4+ T cells from DO11.10 TCR‐transgenic mice. The results suggest that antigen uptake and antigen presentation in DC are regulated by different cytokine signals provided by the surrounding tissue.
Sleep disturbances in Chinese pregnant women

In a prospective study of 247 pregnant Chinese women, the prevalence of sleep disturbances across pregnancy has been assessed using a set of validated questionnaires including the Sleep and Health Questionnaire (SHQ) and the Epworth Sleepiness Scale (ESS). The frequency of self‐reported snoring increased from 29.7% in the first trimester to 40.5% and 46.2% in the second and third trimesters, respectively, with an increase in the prevalence of moderate or severe snoring from 1% in the first trimester to 7.2% in the third trimester (P < 0.01). There was a higher frequency of moderate to severe snoring intensity among subjects with BMI ≥25 compared with those with BMI <25 kg/m2 in the third trimester (20.8%vs 5.3%, P < 0.01). Subjective sleepiness, as determined by the ESS, increased significantly from 8.6 to 9.4 and 9.6 in the first, second and third trimesters, respectively.
Drug delivery strategies for poorly water-soluble drugs: the industrial perspective

Introduction: For poorly soluble compounds, a good bioavailability is typically needed to assess the therapeutic index and the suitability of the compound for technical development. In industry, the selection of the delivery technology is not only driven by technical targets, but also by constraints, such as production costs, time required for development and the intellectual property situation. Areas covered: This review covers current developments in parenteral and oral delivery technologies and products for poorly water-soluble compounds, such as nano-suspensions, solid dispersions and liposomes. In addition, the use of biorelevant dissolution media to assess dissolution and solubility properties is described. Suggestions are also included to systematically address development hurdles typical of poorly water-soluble compounds intended for parenteral or oral administration. Expert opinion: A holistic assessment is recommended to select the appropriate delivery technology by taking into account technical as well as intellectual property considerations. Therefore, first and foremost, a comprehensive physico-chemical characterization of poorly water-soluble compounds can provide the key for a successful selection and development outcome. In this context, the identified physical form of the compound in the formulation is used as a guide for a risk–benefit assessment of the selected oral delivery technology. The potential of nano-suspensions for intravenous administration is unclear. In the case of oral administration, nano-suspensions are mainly used to improve the oral absorption characteristics of micronized formulations. The development of an in situ instantaneous solubilization method, based on stable, standardized liposomes with low toxicity, opens new avenues to solubilize poorly water-soluble compounds.
Prevention and treatment of influenza.

Influenza is a disease known since antiquity that continues to afflict large numbers of people and cause many deaths throughout the world. The annual epidemic and the continued threat of a pandemic constitute a major infectious-disease problem.1–8 Although the prevention of the spread of virus by ill persons and the removal of virus in transit in the environment could theoretically contribute to the control of influenza, effective control requires the optimal use of vaccines and antiviral drugs. At present, a vaccine and four antiviral drugs are approved in the United States and many other countries for the prevention and .
Explicit Deep Holes of Reed-Solomon Codes

In this paper, deep holes of Reed-Solomon (RS) codes are studied. A new class of deep holes for generalized affine RS codes is given if the evaluation set satisfies certain combinatorial structure. Three classes of deep holes for projective Reed-Solomon (PRS) codes are constructed explicitly. In particular, deep holes of PRS codes with redundancy three are completely obtained when the characteristic of the finite field is odd. Most (asymptotically of ratio $1$) of the deep holes of PRS codes with redundancy four are also obtained.
An Automated Approach to Detect Oceanic Eddies From Satellite Remotely Sensed Sea Surface Temperature Data

Cyclonic (anticyclonic) oceanic eddies drive local upwelling (downwelling), leaving footprints in the sea surface temperature (SST) field as local extremes. Satellite-measured SST images can therefore be used to obtain information of the characteristics of oceanic eddies. Remotely sensed measurements represent very large data sets, both spatially and temporally. Manual eddy detection and analysis are thus practically impossible. In this letter, an automated scheme for eddy detection from remote sensing SST data is presented. The method is based on the analysis of velocity fields derived from SST measurements (thermal-wind velocity field). Using the geometric features of the velocity field, we can identify positions of eddy centers and derive eddy size, intensity, path, and lifetime. The scheme is applied to a realistic remotely sensed SST data set in a strong eddy activity region: Kuroshio Extension region.
CBF and CMRO2 during Continuous Etomidate Infusion Supplemented with N2O and Fentanyl in Patients with Supratentorial Cerebral Tumour. A Dose‐Response Study

In 14 patients with supratentorial cerebral tumours with midline shift below 10 mm, CBF and CMRo2 were measured (Kety & Schmidt) during craniotomy. The anaesthesia was continuous etomidate infusion supplemented with nitrous oxide and fentanyl. The patients were divided into two groups. In Group 1 etomidate infusion of 30 μg kg‐1 min‐1 was used throughout the anaesthesia, and CBF and CMRo2 were measured twice. In this group CMRo2 (± s. d.) averaged 2.31±0.43 ml O2 100 g‐1 min‐1 70 min after induction and 2.21 ± 0.38 ml O2 100 g‐1min‐1 130 min after induction. In Group 2 the etomidate infusion was increased from 30 to 60 μg kg‐1 min‐1 after the first study and a significant fall in CMRo2 from 2.52 ± 0.56 to 1.76 ± 0.40 ml O2 100 g‐1 min‐1 was found. Simultaneously, a significant fall in CBF was observed. The CO2 reactivity was preserved during anaesthesia.
The Design, Fabrication, and Testing of an Electromagnetic Micropump with a Matrix-Patterned Magnetic Polymer Composite Actuator Membrane

A valveless electromagnetic (EM) micropump with a matrix-patterned magnetic polymer composite actuator membrane structure was successfully designed and fabricated. The composite membrane structure is made of polydemethylsiloxane (PDMS) that is mixed with magnetic particles and patterned in matrix blocks. The matrix magnetic composite membrane was fabricated using a soft lithography process and expected to have a compact structure having sufficient magnetic force for membrane deformation and maintained membrane flexibility. The magnetic membrane was integrated with the microfluidic system and functionally tested. The experimental results show that a magnetic composite actuator membrane containing of 6% NdFeB is capable of producing a maximum membrane deflection up to 12.87 µm. The functionality test of the EM actuator for fluid pumping resulted in an extremely low sample injection flow rate of approximately 6.523 nL/min. It was also concluded that there is a correlation between the matrix structure of the actuator membrane and the fluid pumping flow rate. The injection flow rate of the EM micropump can be controlled by adjusting the input power supplied to the EM coil, and this is believed to improve the injection accuracy of the drug dosage and have potential in improving the proficiency of the existing drug delivery system.
A Review on Grid-Connected Converter Control for Short-Circuit Power Provision Under Grid Unbalanced Faults

As an increasing amount of converter-based generation on power electronics is connected to power systems, transmission system operators are revising the grid-connection requirements to streamline the connectivity of the devices to maintain security of supply. Converter-based generation can behave significantly different from the traditional alternators under grid faults. In order to evaluate the potential impact of the future converter-based power systems on protective relays, it is necessary to consider diverse current control strategies of voltage-source converters (VSCs) under unbalanced faults as the performance of converters primarily depends on their control objectives. In this paper, current control strategies of VSCs under unbalanced faults for short-circuit power provision are reviewed in two groups, namely, power-characteristic-oriented and voltage-support-oriented control strategy, respectively. As the fault current provided by converters should be restricted within secure operation limits considering semiconductor capabilities, converter current limit issue is also discussed.
Dual effects of arsenic trioxide (As2O3) on non‐acute promyelocytic leukaemia myeloid cell lines: induction of apoptosis and inhibition of proliferation

Summary. Clinical efficacy of As2O3 has been shown in patients with relapsed acute promyelocytic leukaemia (APL). There is evidence that the effects of As2O3 are not restricted to events specific for APL. As2O3 might target mechanisms involved in the pathogenesis of other malignancies. We assessed susceptibility to induction of apoptosis by As2O3 and cytostatics in 22 myeloid and non‐myeloid malignant cell lines. As2O3 was used in concentrations of 0·01–10 µmol/l. Cell lines displayed different kinetics of response and different sensitivity to As2O3. The minimum concentration of As2O3 for induction of apoptosis was 0·1 µmol/l. High concentrations of As2O3 (5 µmol/l) induced apoptosis in a large proportion of cells in all cell lines tested. Low (1 µmol/l As2O3) concentrations induced apoptosis in NB‐4, HL‐60, U‐937, CEM, HL‐60, KG‐1a, PBL‐985, ML‐2 and MV‐4–11, but not in HEL, K‐562, KG‐1 and Jurkat up to 35 d of incubation. However, the non‐apoptotic population of 1 µmol/l As2O3‐treated HEL, K‐562, K‐562 (0·02), K‐562(0·1) and Jurkat showed reduced proliferation. CEM as well as its' multidrug‐resistant derivatives were sensitive to 1 µmol/l As2O3. In summary, these data demonstrate that As2O3‐induced apoptosis is not restricted to cell lines with t(15;17). Apoptosis was induced in vitro by As2O3 concentrations that are achievable in vivo after infusion of well‐tolerated As2O3 doses. Thus, As2O3 might be a suitable therapeutic agent for malignancies other than APL provided the adequate dose and duration of As2O3 treatment are used.
Residues of neonicotinoid insecticides in pollen and nectar from model plants1

Abstract Systemic insecticides used for ornamental horticulture crops can protect all portions of a plant with long-lasting effects. However, they may be hazardous to pollinators foraging on contaminated nectar or pollen. Two model plant cultivars were chosen based upon their ability to produce large quantities of pollen or nectar, enabling examination of the level of nectar or pollen contamination (e.g., insecticide “residues”) following insecticide treatments, rather than for the need or advisability to treat these plants in production nurseries or the landscape with systemic insecticides. These plants were sunflower (Helianthus annuus L. ‘Taiyo') for pollen, and swamp milkweed (Asclepius incarnata L. ‘Ice Ballet') for nectar. Plants were treated at labeled nursery rates with imidacloprid, dinotefuran, or thiamethoxam via foliar spray or soil drench at various times before bloom. Insecticide residues from pollen and nectar varied based upon application method, insecticide, and rate. Assuming that residu.