Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Data-Reuse Transformations on Multimedia Applications for Application Specific Processors

Multimedia applications are characterized by an increased number of data transfers and storage operations. Appropriate transformations can be applied at the algorithmic level to improve crucial implementation characteristics. In this paper, the effect of data-reuse transformations on power consumption and performance of multimedia applications, realized on application specific instruction set processors (ASIP), is examined. An ASIP for multimedia applications, designed based on a complete methodology is used to evaluate this effect. Results prove the efficiency of the ASIP solution and indicate that this approach can benefit, from such transformations, in terms of energy consumption and performance.
E1 Ubiquitin-Activating Enzyme UBA-1 Plays Multiple Roles throughout C. elegans Development

Poly-ubiquitination of target proteins typically marks them for destruction via the proteasome and provides an essential mechanism for the dynamic control of protein levels. The E1 ubiquitin-activating enzyme lies at the apex of the ubiquitination cascade, and its activity is necessary for all subsequent steps in the reaction. We have isolated a temperature-sensitive mutation in the Caenorhabditis elegans uba-1 gene, which encodes the sole E1 enzyme in this organism. Manipulation of UBA-1 activity at different developmental stages reveals a variety of functions for ubiquitination, including novel roles in sperm fertility, control of body size, and sex-specific development. Levels of ubiquitin conjugates are substantially reduced in the mutant, consistent with reduced E1 activity. The uba-1 mutation causes delays in meiotic progression in the early embryo, a process that is known to be regulated by ubiquitin-mediated proteolysis. The uba-1 mutation also demonstrates synthetic lethal interactions with alleles of the anaphase-promoting complex, an E3 ubiquitin ligase. The uba-1 mutation provides a sensitized genetic background for identifying new in vivo functions for downstream components of the ubiquitin enzyme cascade, and it is one of the first conditional mutations reported for the essential E1 enzyme in a metazoan animal model.
An Integrated Analysis of the Genome-Wide Profiles of DNA Methylation and mRNA Expression Defining the Side Population of a Human Malignant Mesothelioma Cell Line

Intratumoral heterogeneity is a hallmark of all cancers and functions as the major barrier against effective cancer therapy. In contrast to genetic mutations, the role of epigenetic modifications in the generation and maintenance of heterogeneous cancer cells remains largely undetermined. This study was performed to evaluate the epigenetic mechanisms involved in the tumor cell heterogeneity using side population (SP) and non-SP cells isolated from a human malignant mesothelioma (HMM) cell line. The subpopulations of cancer cells were analyzed by methylated DNA immunoprecipitation combined with high-throughput sequencing (MeDIP-seq) and RNA-seq methodology. The RNA-seq data were analyzed with the MeDIP-seq data in an integrated way to identify the epigenetically modified genes that defined the SP. Concomitant changes in mRNA expression and DNA methylation were found in 122 genes, including 118 down-regulated genes with hypermethylation and 4 up-regulated genes with hypomethylation. Gene ontology revealed that a large portion of the genes belonged to the groups of biological processes such as stem cell maintenance, stem cell development, stem cell differentiation, and the negative regulation of the developmental process. Among these genes, BNC1, RPS6KA3, TWSG1 and DUSP15 contained aberrant methylation in the CpG islands of the promoter region, indicating that the genes regulated by DNA methylation characterized a distinct subpopulation of HMM cells. The present study provided valuable information to shed light on the epigenetic contributions to the generation and maintenance of tumor cell heterogeneity.
Millimeter-Wave Imaging Sensor

A scanning 3-mm radiometer system has been built and used on a helicopter to produce moderate resolution (0.5°) images of the ground. This mm-wave sensor can be used for a variety of remote sensing applications, and produces images through clouds, smoke, and dust when visual and IR sensors are not usable. The system is described, and imaging results are presented.
Moving markup: repositioning freeform annotations

Freeform digital ink annotation allows readers to interact with documents in an intuitive and familiar manner. Such marks are easy to manage on static documents, and provide a familiar annotation experience. In this paper, we describe an implementation of a freeform annotation system that accommodates dynamic document layout. The algorithm preserves the correct position of annotations when documents are viewed with different fonts or font sizes, with different aspect ratios, or on different devices. We explore a range of heuristics and algorithms required to handle common types of annotation, and conclude with a discussion of possible extensions to handle special kinds of annotations and changes to documents.
Development of a model for clinical assessment of religious coping: Initial validation of the Process Evaluation Model

The relationship of religion to mental health has been widely researched in recent years, and has pointed to both positive and negative implications of religious coping. Traditionally, those interested in evaluating coping have looked at the efficacy of a particular coping activity. However, coping theory suggests that no one coping strategy is always effective or ineffective. Instead the efficacy of the coping process depends more on the flow, or process, of coping versus simply the outcomes of coping. This study proposes the Process Evaluation Model of religious coping, which defines well being as the degree to which the elements of the coping process are well integrated. Mental health practitioners and clergy (n = 166) completed a survey instrument developed for this study consisting of six vignettes. Each story reflected different degrees of integration in an individual coping with a personal crisis. Using a mixed design, we found support for the Process Evaluation Model. All participants were able to identify well integrated versus poorly integrated religious coping processes. Clinicians and clergy did not differ in their evaluation despite the historical rift between mental health and religion. Implications for clinical assessment and intervention are discussed as well as future directions for research using the Process Evaluation Model.
D2 Dopamine Receptor-Mediated Modulation of Voltage-Dependent Na+ Channels Reduces Autonomous Activity in Striatal Cholinergic Interneurons

Striatal cholinergic interneurons are critical elements of the striatal circuitry controlling motor planning, movement, and associative learning. Intrastriatal release of dopamine and inhibition of interneuron activity is thought to be a critical link between behaviorally relevant events, such as reward, and alterations in striatal function. However, the mechanisms mediating this modulation are unclear. Using a combination of electrophysiological, molecular, and computational approaches, the studies reported here show that D2 dopamine receptor modulation of Na+ currents underlying autonomous spiking contributes to a slowing of discharge rate, such as that seen in vivo. Four lines of evidence support this conclusion. First, D2 receptor stimulation in tissue slices reduced the autonomous spiking in the presence of synaptic blockers. Second, in acutely isolated neurons, D2 receptor activation led to a reduction in Na+ currents underlying pacemaking. The modulation was mediated by a protein kinase C-dependent enhancement of channel entry into a slow-inactivated state at depolarized potentials. Third, the sodium channel blocker TTX mimicked the effects of D2 receptor agonists on pacemaking. Fourth, simulation of cholinergic interneuron pacemaking revealed that a modest increase in the entry of Na+ channels into the slow-inactivated state was sufficient to account for the slowing of pacemaker discharge. These studies establish a cellular mechanism linking dopamine and the reduction in striatal cholinergic interneuron activity seen in the initial stages of associative learning.
Prognostic significance of her‐2/neu expression in breast cancer and its relationship to other prognostic factors

Archival surgical specimens from 1,210 female breast cancer patients treated between 1968 and 1971 and with a 19‐year follow‐up were reanalyzed with special reference to several parameters, such as size of the primary tumor, axillary nodal involvement, histologic grade, degree of inflammatory infiltrate (LPI) of the tumor and expression of the neu onco‐protein (p185) as detected by immunohistochemistry. In a multifactorial analysis the 4 former factors were found to be independent prognostic parameters. Over‐expression of p 185 was found to be related to tumor size and grade and to LPI but not to pathologic nodal status. Over‐expression of p185 showed a negative impact upon survival in node‐positive but not in node‐negative patients. However, in the subset of node‐negative patients without LPI, p185 over‐expression showed the same correlation with a poor prognosis as in node‐positive patients. In contrast, in node‐negative and LPI‐positive patients, p185 over‐expression correlated with a good prognosis. Also, the prognosis of patients with positive nodes, presence of LPI and no p185 over‐expression was similar to that of patients with negative nodes, absence of LPI and p185 over‐expression.
Overview of NTCIR-10

This is an overview of NTCIR-10, the tenth sesquiannual workshop for the evaluation of Information Access technologies. NTCIR-10 celebrates its tenth cycle of the research activities attracting the largest and most diverse set of evaluation tasks led by cutting-edge researchers worldwide. This paper presents a brief history of NTCIR and overall statistics of NTCIR-10, followed by an introduction of eight evaluation tasks. We conclude the paper by discussing the future directions of NTCIR. Readers should refer to individual task overview papers for their activities and ﬁndings.
Image-Based Surface Detail Transfer

geometric details is desirable in many real-world applications. We might want to know, for example, how a wall would look after adding some geometrical bumps, or how a person would look after adding wrinkles on his or her face. Direct methods for adding geometric details to an object require modeling the object and the surface details. It’s usually not a trivial task to build a 3D model for a real object. It’s also tedious and labor intensive to model and create surface details with existing geometric modeling tools. Bump mapping has acted as an alternative to adding geometrical details to an otherwise smooth object. But constructing visually interesting bump maps requires practice and artistic skills. Computer vision techniques have helped for modeling real-world objects and their surface details. Techniques include the use of laser scanner, stereo algorithms, shape from lighting variation, shape from shading, and so on. However, some of these techniques require specialized equipment. Many other techniques require at least two images of each object, and capturing highresolution geometrical details robustly can be difficult. Although the shape-from-shading technique only requires a single image, this approach usually requires knowledge of the lighting condition and reflectance functions of the surface material. Three-dimensional recognition and reconstruction from a single image have used linear classes of objects. But this reconstruction technique doesn’t generate accurate geometric details. In our approach, for cases where we only want to transfer geometrical details from one object to another, we might not need to explicitly compute 3D structures. In particular, our novel technique captures the geometrical details of an object from a single image in a way that is independent of the object’s reflectance property. We can then transfer geometrical details to another surface, producing the appearance of a new surface with added geometrical details while preserving the object’s reflectance property. Our method’s advantages are that it’s simple to implement, requires only a single image for each object, and produces effective results. An earlier version of this article appeared in the Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition. In this revised version, we show that this technique is suitable as a fast and effective touch-up tool for photo editing. In particular, it can remove wrinkles and color spots on face images.
The expenditures related to the use of antifungal drugs in patients with hematological cancers: a cost analysis

Objective The aim of this study is to analyze the expenditures related to the use of antifungal drugs in patients with hematological malignancies. Methods In this retrospective study, the expenditures related to use of antifungal drugs for treatment of invasive fungal infections in patients with hematological malignancies between November 2010 and November 2012 were analyzed. Expenditures of antifungal drugs were calculated by converting the price billed to the Republic of Turkey Social Security Institution per patient using the US dollar ($) exchange rate. Results We retrospectively analyzed the expenditures related to the use of antifungal drugs in 282 febrile episodes of 126 neutropenic patients. Voriconazole (VOR), caspofungin, and liposomal amphotericin B (L-AmB) were administered as a first-line antifungal therapy to treat 72 febrile episodes of 65 neutropenic patients, 45 febrile episodes of 37 neutropenic patients, and 34 febrile episodes of 32 neutropenic patients, respectively. The expenditures related to the use of antifungal drugs per febrile neutropenic episode were $3,857.85 for VOR; $15,783.34 for caspofungin, and $21,561.02 for L-AmB, respectively. The expenditure related to the use of posaconazole (POS) was $32,167.39 per patient for primary or secondary prophylaxis. Conclusion Improving conditions in the patient’s room, choosing pre-emptive antifungal treatment instead of empirical antifungal treatment, switching to tablet form of VOR after initiation of its intravenous form, secondary prophylaxis with VOR against invasive aspergillosis, primary prophylaxis with POS in high-risk patients, and choosing less L-AmB as being an alternative to other antifungal drugs, may reduce expenditures related to the use of antifungal drugs in the treatment of invasive fungal infections during febrile neutropenic episodes of patients with hematological malignancies.
Culturable fungal diversity of shrimp Litopenaeus vannamei boone from breeding farms in brazil

Litopenaeus vannamei, which is the most common shrimp species cultivated in the northeast of Brazil, is very susceptible to microbial diseases, and this consequently affects productivity. There are reports of bacteria, viruses and protozoa in these shrimp, but not fungi. This study aims to isolate and identify fungi present in shrimp Litopenaeus vannamei, and in their nursery waters, at two breeding farms in Brazil. The pathogenic potential of the isolates was assessed through the qualitative detection of proteases and aflatoxin B production. The 146 isolated fungi comprised 46 species. Aspergillus, Penicillium and Furarium were the three most relevant genera and Aspergillus flavus was the predominant species with a total of 33 isolates. Most of the isolated species are known as potentially pathogenic to humans and other animals. Eighteen isolates of A. flavus and two of A. parasiticus were able to produce aflatoxin B and 33 out of the 46 species produced protease, indicating that these fungi may also become pathogenic to shrimp and their consumers.
Qu'est-ce qu'une école juste ?

Ce texte part de la multiplicite des manieres de definir les enjeux de justice auxquels l’ecole fait face. Un premier modele est celui de l’egalite des chances meritocratique. Un second invite a rompre avec la stricte egalite pour compenser les inegalites sociales en donnant plus a ceux qui ont moins. Un troisieme modele met en avant la notion d’un minimum de savoirs et de competences garantis. Enfin, un quatrieme insiste sur l’independance des «spheres de justice», une ecole juste etant celle dont les hierarchies ont relativement peu de consequences au sortir de l’ecole, celle qui est d’abord soucieuse de l’integration sociale de tous et celle dont les classements n’affectent pas l’egale dignite des individus. De fait, chacune de ces conceptions de la justice s’avere contradictoire avec les autres, sinon dans l’ordre des principes, du moins dans celui des pratiques et des politiques scolaires. Pour eclairer les limites de chacun des modeles, le texte s’appuie sur les resultats etablis par la sociologie de l’education. La conclusion est que l’ecole juste ne peut etre le fruit d’un seul principe de justice, mais plutot le produit plus ou moins stabilise d’une combinaison de principes croises et attenuant reciproquement leurs effets.
Linking estrogen to Alzheimer's disease

Epidemiologic studies suggest that estrogen protects against AD.We employ ARROWSMITH, a novel computer-assisted approach, to identify possible links between estrogen and AD that are not explicit in the biomedical literature, by searching for substances or processes that are known targets of estrogen action and that have also been separately studied in relation to AD. Several links appear particularly promising (e.g., estrogen's antioxidant activity) and merit attention by neuroscientists. NEUROLOGY 1996;47: 809-810
Integrating auditory and visual perception for robotic soccer players

We present a method of integrating auditory and visual perception for RoboCup mobile robots. When humanoid robots are fielded for soccer game, they need to quickly react to the environment using all possible sensory inputs. While current robots heavily depends on visual inputs, auditory inputs actually play significant role in detecting events where visual inputs are not available, such as on the side and behind the face direction. Sound of other players kicking the ball, and shouting of team-mates are critical cues for sophisticated teamwork play, such as the offside trap. This paper presents an integration of auditory and visual perception for identifying sound sources and separating sounds at high accuracy using both auditory and visual inputs.
Internal derangement as a predictor of provoked pain on mouth opening: A magnetic resonance imaging study

Purpose This study investigated the relationship between pain and internal derangement in temporomandibular disorder (TMD) patients using magnetic resonance imaging (MRI). Materials and Methods This study analyzed 356 TMD patients (712 temporomandibular joints [TMJs]). The inclusion criteria were the presence of spontaneous or provoked pain on one or both TMJs and having undergone MRI. The patients with provoked pain were divided into 3 groups: pain on palpation, pain on mouth opening, and pain on mastication. MRI was performed using a 1.5-T scanner. T1- and T2-weighted parasagittal and paracoronal images were obtained. According to the findings on the T1-weighted images, another 3 groups were created based on internal derangement: normal, disc displacement with reduction, and disc displacement without reduction. The MRI findings were independently interpreted by 2 experienced oral and maxillofacial radiologists at 2 different times. Statistical analysis was performed by the chi-square test using SPSS (version 12.0; SPSS Inc., Chicago, IL, USA). Results Provoked pain on mouth opening was found to be correlated with internal derangement in TMD patients (P<.05). However, spontaneous pain and provoked pain on palpation or mastication were not associated with internal derangement (P>.05). Conclusion These results suggest that internal derangement was a significant predictor of provoked pain on mouth opening.
HSDPA Performance with Dual Stream MIMO in a Combined Macro-Femto Cell Network

3rd Generation Partnership Project (3GPP) responsible of the standardization of 3G systems selected dual stream Transmit Antenna Array (D-TxAA) as the Multiple Input - Multiple Output (MIMO) scheme for High Speed Downlink Packet Access (HSDPA) in 3GPP specification Release 7. MIMO doubles the theoretical peak data rate of HSDPA from 14.4 Mbps to 28.8 Mbps. However, successful reception of dual stream MIMO transmissions requires good signal conditions. Very high signal to noise ratios can be achieved with the use of femto base stations in small isolated areas with insufficient or no macro cell coverage. This paper studies the effect of D-TxAA concept in a combined single frequency macro and femto cell scenario with Linear Minimum Mean Squared Error (LMMSE) chip-level equalizer receivers used at user entities (UE). The impact of receivers employing MIMO transmission mode is analyzed as a function of indoor user penetration using fully dynamic system level simulations.
The Search for a Survival Value of Music

A most basic issue in the study of music perception is the question of why humans are motivated to pay attention to, or create, musical messages, and why they respond emotionally to them, when such messages seem to convey no real-time relevant biological information as do speech, animal utterances, and environmental sounds. Expanding on previous work (Roederer, 1979,1982) three possibly concurrent factors will be examined: (1) The inborn motivation to train language-handling networks of the brain in the processing of simple, organized sound patterns as a prelude to the acquisition of language; (2) The need to extract the information contained in the "musical" components of speech; (3) The value of music as a means of transmitting information on emotional states and its effect in congregating and behaviorally equalizing masses of people. In the discussion, special attention will be paid to the role of motivation and emotion in auditory perception, to the fact that in humans limbic system functions can be activated by internally evoked images in complete detachment from the current state of environment and organism, and to the existence of two distinct strategies of cerebral information processing, namely short-term time sequencing, as required in speech communication and thinking, and holistic pattern recognition, as required in music perception.