Miracle-dz/UniFAR-FTUs huggingface dataset:
Decreased expression of p 73 in colorectal cancer

Introduction. The colorectal cancer (CRC) is one of the most frequent cancer in Poland and worldwide. This disease is characterized by distinct genetic alterations. p73 belongs to the p53 gene family; however, its role in the pathogenesis of CRC has not been completely understood. p73 gene encodes several mRNA variants and protein isoforms with its longest and fully functional p73a (mRNA) and TAp73a (protein) isoform. The aim of the study was to investigate p73 gene expression at the mRNA (p73a) and protein (TAp73a) levels in CRC. Material and methods. Small sections of the CRC tumor tissue and macroscopically unchanged colon mucosa and submucosa from the dissection margin were collected from 23 patients diagnosed with CRC. p73 mRNA levels were measured by Real-time PCR (QPCR) method and the expression level of TAp73a protein was assessed by Western blotting (WB) and immunohistochemical (IHC) staining. Results. We found a 37% decrease in the level of p73a mRNA in neoplastically changed (tumor) compared with unchanged normal colon tissue from the surgical margin (p = 0.041). No correlations were found between mRNA levels in cancer tissue and clinical-pathological parameters. The semi-quantification of TAp73a protein revealed lower and higher TAp73a protein contents in 11/23 and 12/23 of tumor samples, respectively, when compared with the median value of TAp73a protein in normal colon tissue (p = 0.61). The level of TAp73a protein level was 5 times lower in poorly differentiated cancer cells (G3) in comparison to moderately differentiated ones (G2; p = 0.02). No statistically significant correlations were observed between the level of the TAp73a protein and clinical-pathological patients’ characteristics. The IHC analysis of TAp73a protein presence in CRC samples showed decreased immunoreactivity when compared with matched sections of the unchanged colon wall in 4/9 patients, similar intensity of the IHC reaction in 4/9 patients and increased immunoreactivity in 1/9 patients. The TAp73a protein was localized mainly in the cytoplasm of the cancer cells. No statistically significant correlations between IHC results and clinical-pathological features of the patients were found. Conclusions. The obtained results suggest that the p73 gene may play a role as a tumor suppressor in the CRC progression. (Folia Histochemica et Cytobiologica 2016, Vol. 54, No. 3, 166–170)
ULTRA WIDEBAND POWER DIVIDER USING TAPERED LINE

A power divider with ultra-wideband (UWB) performance has been designed. The quarter-wave transformer in the conventional Wilkinson power divider is replaced by an exponentially tapered microstrip line. Since the tapered line provides a consistent impedance transformation across all frequencies, very low amplitude ripple of 0.2dB peak-to-peak in the transmission coe-cient and superior input return loss better than 15dB are achieved over an ultra-wide bandwidth. Two additional resistors are added along the tapered line to improve the output return loss and isolation. Simulation performed using CST Microwave Studio and measured results conflrm the good performance of the proposed circuit. The return loss and the isolation between the output ports are better than 15dB across the band 2{ 10.2GHz. Standard ofi-the-shelf resistance values can be selected by optimizing the physical locations to mount the resistors. Better performance can be achieved with more isolation resistors added. Hence, the number of isolation resistors to be used may be selected based on the desired bandwidth and level of isolation and return loss speciflcations.
Visual Speech and Speaker Recognition

This thesis presents a learning based approach to speech recognition and person recognition from image sequences. An appearance based model of the articulators is learned from example images and is used to locate, track, and recover visual speech features. A major difficulty in model based approaches is to develop a scheme which is general enough to account for the large appearance variability of objects but which does not lack in specificity. The method described here decomposes the lip shape and the intensities in the mouth region into weighted sums of basis shapes and basis intensities, respectively, using a Karhunen-Loeve expansion. The intensities deform with the shape model to provide shape independent intensity information. This information is used in image search, which is based on a similarity measure between the model and the image. Visual speech features can be recovered from the tracking results and represent shape and intensity information. A speechreading (lip-reading) system is presented which models these features by Gaussian distributions and their temporal dependencies by hidden Markov models. The models are trained using the EM-algorithm and speech recognition is performed based on maximum posterior probability classification. It is shown that, besides speech information, the recovered model parameters also contain person dependent information and a novel method for person recognition is presented which is based on these features. Talking persons are represented by spatio-temporal models which describe the appearance of the articulators and their temporal changes during speech production. Two different topologies for speaker models are described: Gaussian mixture models and hidden Markov models. The proposed methods were evaluated for lip localisation, lip tracking, speech recognition, and speaker recognition on an isolated digit database of 12 subjects, and on a continuous digit database of 37 subjects. The techniques were found to achieve good performance for all tasks listed above. For an isolated digit recognition task, the speechreading system outperformed previously reported systems and performed slightly better than untrained human speechreaders.
A Low-Complexity Decoding Algorithm for Coded Hierarchical Modulation in Single Frequency Networks

In this paper, the hierarchical modulation (HM) technique is adopted in a single frequency network (SFN) to provide both global and local information. In order to mitigate the interlayer interference and intercell interference, we develop a low-complexity successive interference cancellation (SIC) algorithm for the coded HM signals in the SFN. The proposed decoding algorithm can be applied to different soft-decision channel coding schemes (e.g., Turbo codes, LDPC codes) under various channel profiles. We analyzed the decoding complexity of the proposed algorithm, and evaluated the bit error rate performance. The simulations show that the new decoding algorithm can offer up to 0.7 dB carrier to noise ratio ((C/N)) gain compared with the traditional SIC approach under different channel models, while providing the comparable performance (up to 95% decoding complexity savings) with the multilayer iterative decoding approach. The performance evaluation and decoding complexity comparisons indicate that the proposed structured SIC approach offers a good performance-complexity trade-off, especially for the HM-based SFN scenarios.
Interleukin-2 levels in exhaled breath condensates, asthma severity, and asthma control in nonallergic asthma.

There was evidence that interleukin (IL)-2 and IL-10 in the airways play roles in regulating the asthmatic inflammatory response. The purpose of this study was to measure the levels of these cytokines in exhaled breath condensates (EBCs) from asthmatic airways and their correlation with a clinical assessment of asthma severity. The levels of IL-2 and IL-10 in EBC, Asthma Control Test (ACT) score, and the forced expiratory volume in 1 second (FEV1) were studied in 28 steroid-free asthmatic patients and 10 healthy volunteers. The results were analyzed according to their allergic status, asthma severity, and body weight. The correlations between IL-2 and IL-10 levels, percent predicted FEV1, ACT score, and body mass index were also determined. Both IL-2 and IL-10 levels in EBC significantly increased in asthmatic patients, especially in patients with moderate-to-severe persistent asthma, compared with those in normal controls. However, the signification correlations between IL-2 levels and ACT (r = -0.684; p = 0.007), as well as with percent predicted FEV1 (r = -0.671; p = 0.009), were established only in patients with nonallergic asthma. The elevation of IL-2 levels in EBC in obese subjects was observed but was probably related to asthma severity. The levels of IL-2 and IL-10 in EBC increase in asthmatic patients but only IL-2 levels significantly correlate with the ACT score and percent predicted FEV1 in nonallergic asthma. Additional studies should be explored to confirm the reliability of ACT score as a predictor of inflammatory response in asthmatic airways. Clinical trial NCT01246414, http://www.clinicaltrials. gov.
Microburst insulin infusion: results of observational studies – carbohydrate metabolism, painful diabetic neuropathy, and hospital/emergency department utilization

1Banner University Medical Center, USA 2Greater Miami Skin and Laser Center, USA 3Herbert Wertheim College of Medicine, USA 4Loma Linda University Newport Beach, USA 5Trina Health of Birmingham, USA 6Trina Health of West Los Angeles, USA 7Advanced Metabolic Care Associates, USA 8Trina Health of San Diego, USA 9Trina Health of Las Vegas, USA 10Trina Health of Oklahoma, USA 11Trina Health of Foley, USA 12Trina Health of Arizona, USA 13Trina Health of Dallas, USA 14Trina Health, USA 15NeoMark Ventures, USA
Ca2+-dependent Regulation of TrkB Expression in Neurons*

The neurotrophin brain-derived neurotrophic factor (BDNF), via activation of its receptor, tyrosine receptor kinase B (trkB), regulates a wide variety of cellular processes in the nervous system, including neuron survival and synaptic plasticity. Although the expression of BDNF is known to be Ca2+-dependent, the regulation of trkB expression has not been extensively studied. Here we report that depolarization of cultured mouse cortical neurons increased the expression of the full-length, catalytically active isoform of trkB without affecting expression of the truncated isoform. This increase in protein expression was accompanied by increased levels of transcripts encoding full-length, but not truncated, trkB. Depolarization also regulated transcription of the gene, TRKB, via entry of Ca2+ through voltage-gated Ca2+ channels and subsequent activation of Ca2+-responsive elements in the two TRKB promoters. Using transient transfection of neurons with TRKB promoter-luciferase constructs, we found that Ca2+ inhibited the upstream promoter P1 but activated the downstream promoter P2. Ca2+-dependent stimulation of TRKB expression requires two adjacent, non-identical CRE sites located within P2. The coordinated regulation of BDNF and trkB by Ca2+ may play a role in activity-dependent survival and synaptic plasticity by enhancing BDNF signaling in electrically active neurons.
Development and Validation of the Heidelberg Form for Emotion Regulation Strategies (HFERST): Factor Structure, Reliability, and Validity

The Heidelberg Form for Emotion Regulation Strategies (HFERST) was developed to complement previous emotion regulation (ER) questionnaires and addresses some of their limitations by measuring eight ER strategies. An initial item pool was developed in German following expert discussions and adaptation of the items from existing ER scales. Following a stepwise selection based on the experts’ judgments, 32 items with the best content validity were chosen. Results of an exploratory factor analysis in Study 1 (N = 399) and two confirmatory factor analyses in Studies 2 (N = 715) and 3 (N = 408) supported the eight-factor structure of the HFERST and provided evidence for its internal consistency, construct and criterion validity, and clinical utility. Study 4 supported a 2-week stability of the HFERST and Study 5 showed that, following an ER intervention, the HFERST captured a reduction in dysfunctional and an improvement in functional ER strategies, which again supports the clinical utility of the HFERST.
School-Based Mindfulness Instruction: An RCT

BACKGROUND AND OBJECTIVE: Many urban youth experiencesignificant and unremitting negative stressors, including those associated with community violence, multigenerational poverty, failing educational systems, substance use, limited avenues for success, health risks, and trauma. Mindfulness instruction improves psychological functioning in a variety of adult populations; research on mindfulness for youth is promising, but has been conducted in limited populations. Informed by implementation science, we evaluated an adapted mindfulness-based stress reduction (MBSR) program to ameliorate the negative effects of stress and trauma among low-income, minority, middle school public school students. METHODS: Participants were students at two Baltimore City Public Schools who were randomly assigned by grade to receive adapted MBSR or health education (Healthy Topics [HT]) programs. Self-report survey data were collected at baseline and postprogram. Deidentified data were analyzed in the aggregate, comparing MBSR and HT classes, by using regression modeling. RESULTS: Three hundred fifth- to eighth-grade students (mean 12.0 years) were in MBSR and HT classes and provided survey data. Participants were 50.7% female, 99.7% African American, and 99% eligible for free lunch. The groups were comparable at baseline. Postprogram, MBSR students had significantly lower levels of somatization, depression, negative affect, negative coping, rumination, self-hostility, and posttraumatic symptom severity (all Ps < .05) than HT. CONCLUSIONS: These findings support the hypothesis that mindfulness instruction improves psychological functioning and may ameliorate the negative effects of stress and reduce trauma-associated symptoms among vulnerable urban middle school students. Additional research is needed to explore psychological, social, and behavioral outcomes, and mechanisms of mindfulness instruction.
Colorectal tumour deposits in the mesorectum and pericolon; a critical review

Although tumour deposits (TD) in the pericolic and mesorectal fat have been recognized since 1935, incorporation in the Tumour Node Metastasis (TNM)/American Joint Committee on Cancer (AJCC) system took place in 1997. The 3‐mm rule classified TD as lymph node metastases. This rule was changed in 2002, when the contour of the deposit became the diagnostic feature. This review has evaluated the 3714 patients described in the literature. The incidence of TD varies from 5 to 45%. Their origin has been shown to be heterogeneous; however, their presence indicates a poorer survival. The hazard ratio for death due to disease is 1.96. Various studies have tried to determine the importance of types of TD, based on contour, size and origin, but all fail to provide an evidence base to substantiate its use in the TNM system. To classify TD as positive lymph nodes after neoadjuvant therapy is a misconception, since the presence of tumour microfoci after therapy can be a sign of good response to treatment and indicative of a good prognosis. In conclusion, we did not find adequate evidence for the inclusion of TD in TNM/AJCC staging systems. Moreover, the current directives are confusing, and the definitions should not be used after neoadjuvant therapy.
Skinfold thicknesses: is there a need to be very precise in their location?

Skinfold thicknesses represent a comparatively simple and reasonably accurate assessment of body fatness which is an important part of the estimation of nutritional state. However, much emphasis is placed on the necessity to be very precise in the exact position of the skinfold being measured and there is frequently concern, also, about the variability of the measurement by different observers using different types of caliper. Fifty-three women and forty-five men had four skinfolds (biceps, triceps, supra-iliac and subscapular) measured first at the standard sites (Tanner, 1953; Edwards et al. 1955), and then at deliberately chosen sites about 20 mm distant from the ‘correct’ ones. The effect on the estimation of body fatness by this manoeuvre resulted in a difference of usually less then 1% and, at a maximum, 3%. In the light of the uncertainty of the basic assumptions which are made in extrapolating from skinfolds (or indeed densitometry, total body water, total body K, and others) to body fatness, these technical errors assume comparatively little importance.
Ambient particulate pollution and the world-wide prevalence of asthma, rhinoconjunctivitis and eczema in children: Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC)

Objectives To investigate the effect of ambient particulate matter on variation in childhood prevalence of asthma, rhinoconjunctivitis and eczema. Methods Prevalences of asthma, rhinoconjunctivitis and eczema obtained in Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC) were matched with city-level estimates of residential PM10 obtained from a World Bank model. Associations were investigated using binomial regression adjusting for GNP per capita and for clustering within country. For countries with more than one centre, a two stage meta-analysis was carried out. The results were compared with a meta-analysis of published multi-centre studies. Results Annual concentrations of PM10 at city level were obtained for 105 ISAAC centres in 51 countries. After controlling for GNP per capita, there was a weak negative association between PM10 and various outcomes. For severe wheeze in 13–14-year-olds, the OR for a 10 μg/m3 increase in PM10 was 0.92 (95% CI 0.84 to 1.00). In 24 countries with more than one centre, most summary estimates for within-country associations were weakly positive. For severe wheeze in 13–14-year-olds, the summary OR for a 10 μg/m3 increase in PM10 was 1.01 (0.92 to 1.10). This result was close to a summary OR of 0.99 (0.91 to 1.06) obtained from published multi-centre studies. Conclusions Modelled estimates of particulate matter at city level are imprecise and incomplete estimates of personal exposure to ambient air pollutants. Nevertheless, our results together with those of previous multi-centre studies, suggest that urban background PM10 has little or no association with the prevalence of childhood asthma, rhinoconjunctivitis or eczema either within or between countries.
A Continuous - Time Quantum Walk for Attributed Graphs Matching

Diverse facets Of the Theory of Quantum Walks on Graph are reviewed Till now . In specific, Quantum network routing, Quantum Walk Search Algorithm, Element distinctness associated to the eigenvalues of Graphs and the use of these relation /connection in the study of Quantum walks is furthermore described. Different Researchers had contribution and put their benchmark idea Pertaining with this research concept. I furthermore try to investigate recent Application of Quantum walks, In specific the problem pertained with Graph matching i.e Matching nodes(vertices) of the Graphs. In this research paper,I consider how Continuous-time quantum walk (CTQW) can be directed to Graph-matching problems. The matching problem is abstracted using weighted(attributed) Graphs that connects vertices's of one Graph to other and Try to compute the distance b/n those Graphs Node's Beside that finding the matched nodes and the Cost related to Matching. eventually measuring the distance between two Graphs which might have different size then by using k-nearest neighbor (k-NN) method try to classifying those graph based on closest training examples in the feature space.
Gaining Insight from Physical Activity Data using a Similarity-based Interactive Visualization

This paper presents a new interactive visualization approach which aims to help and support the user in gaining insight over his physical activity data. The main novelty of the proposed visualization approach is the representation of similarities in the physical activity patterns in time using data clustering techniques, in addition to the continuous physical activity representation over a circular chart. This grouping of similar activity patterns helps identifying meaningful events or behaviors, combined with the periodicity highlighting circular charts. The user is able to interact with the visualization during the knowledge discovery process by changing the represented time-scale, time-frame and the number of clusters used for the user’s physical activity pattern categorization. Additionally, the proposed visualization approach allows to easily report and store the insights gained during the visual data analysis process, by adding a textual description linked to the particular user tailored visualization configuration which led to that insight.
Multi-agent learning approach to dynamic security patrol routing

Patrols are groups of security personnel, such as police officers or soldiers, whose main job is patrolling an area to maintain peace. In this study, we simulate their activities in an artificial urban environment similar to a real city that has banks, shops, and other hotspots that may attract crime. It is believed that specific patrol routes have influence in reducing crime rates. We propose a multi-agent-based XCS learning classifier system implementation to generate their behaviors to learn better route to prevent a possible crime outbreak in the neighborhood.
Liquid-Crystal Terahertz Quarter-Wave Plate Using Chemical-Vapor-Deposited Graphene Electrodes

Quarter-wave operation or a phase shift of more than π/2, which is approximately ten times greater than that reported in previous works using liquid crystals (LCs) and graphene electrodes, was demonstrated. The device is transparent to the terahertz (THz) wave, and the driving voltage required was as low as approximately 2.2 V (rms), which is also unprecedented. Experimental results supported a theoretical formalism adapted for LC cells with THz wavelength-scale thickness. The scattering rate, DC mobility, and carrier mean free path of bilayer graphene were also determined using THz spectroscopic techniques; the parameters were inferior to those of monolayer graphene. This observation can be attributed to the higher density of charged impurities in the bilayer graphene. The device performances of LC phase shifters using monolayer and bilayer graphene as electrodes were essentially identical.
Development and Implementation of an Interactive Parallelization Assistance Tool for OpenMP: iPat/OMP

iPat/OMP is an interactive parallelization assistance tool for OpenMP. In the present paper, we describe the design concept of iPat/OMP, the parallelization sequence achieved by the tool and its current implementation status. In addition, we present an evaluation of the performance of the implemented functionalities. The experimental results show that iPat/OMP can detect parallelism and create an appropriate OpenMP directive for several for-loops.
The error probability of M-ary PSK block coded modulation schemes

A tight upper bound on the decoding error probability is derived for block-coded modulation structures where an M-ary phase shift keying (M-PSK) signal constellation is employed. This bound, called a tangential sphere bound, is tight for very low (as well as for high) signal-to-noise ratios (SNRs). Berlekamp's tangential union bound, previously derived for binary codes, can be derived for an M-PSK block coded modulation structure as well. However, it is proven that our tangential sphere bound is tighter than Berlekamp's (1980) tangential bound. For particular schemes, it is shown that for low SNRs our bound is considerably tighter than the tangential bound. As one of the examples, a multistage decoder is considered.