Miracle-dz/UniFAR-FTUs huggingface dataset:
Contact of dual mobility implants: effects of cup wear and inclination

Cup wear and inclination on the pelvic bone are significant factors, which change the contact of the articulating surfaces, thus, impacting the long-term performance of hip implants. This paper presents a finite element (FE) analysis of the contact of the dual mobility implants under the influence of cup wear and inclination. A 3D FE model of the implant was developed with the application of equivalent physiological loading and boundary conditions. Effects of cup inclination angle ranging from 45° to 60° and the wear depth ranging from 0 to 2.46 mm equivalent to up to 30 years of the implant's life on the contact pressure and von Mises stress were investigated. Simulation results show that the contact pressure and von Mises stress decrease significantly with a modest wear depth and remains quite in-sensitive to the cup inclination angle and wear depth up to 1.64 mm. With wear depth further up to 2.46 mm, the cup thickness (i.e. cup thinning on worn region) may be more predominant than increasing of contact area between the cup and the head. The wear on the inner surface of the cup is found to rule out the overall contact pressure and stress in the implant. Furthermore, individual and combined effects of both important parameters are analysed and discussed with respect to available clinical/laboratory studies.
Direct Identification of an HPV-16 Tumor Antigen from Cervical Cancer Biopsy Specimens

Persistent infection with high-risk human papilloma viruses (HPV) is the worldwide cause of many cancers, including cervical, anal, vulval, vaginal, penile, and oropharyngeal. Since T cells naturally eliminate the majority of chronic HPV infections by recognizing epitopes displayed on virally altered epithelium, we exploited Poisson detection mass spectrometry (MS3) to identify those epitopes and inform future T cell-based vaccine design. Nine cervical cancer biopsies from HPV-16 positive HLA-A*02 patients were obtained, histopathology determined, and E7 oncogene PCR-amplified from tumor DNA and sequenced. Conservation of E7 oncogene coding segments was found in all tumors. MS3 analysis of HLA-A*02 immunoprecipitates detected E711–19 peptide (YMLDLQPET) in seven of the nine tumor biopsies. The remaining two samples were E711–19 negative and lacked the HLA-A*02 binding GILT thioreductase peptide despite possessing binding-competent HLA-A*02 alleles. Thus, the conserved E711–19 peptide is a dominant HLA-A*02 binding tumor antigen in HPV-16 transformed cervical squamous and adenocarcinomas. Findings that a minority of HLA-A*02:01 tumors lack expression of both E711–19 and a peptide from a thioreductase important in processing of cysteine-rich proteins like E7 underscore the value of physical detection, define a potential additional tumor escape mechanism and have implications for therapeutic cancer vaccine development.
Prediction of turning points for chaotic time series using ensemble ANN model

A machine learning approach to predict turning points for chaotic time series was proposed through incorporating chaotic analysis into ensemble artificial neural network (ANN) modeling. The EM-like parameter learning algorithm for ensemble ANN model was presented. We then gave a new GA-based threshold optimization procedure using out-of-sample validation. The proposed approach was demonstrated on the benchmark chaotic time series like Mackey-Glass system. Our experimental results show significant improvement in performance over ANN model alone.
The Relationship between the Curriculum and Test Development: Some Considerations for the Future.

ABSTRACT This paper presents future interactions between curriculum and test content, particularly standardized achievement test content. Three topics are discussed in question-answer form. (1) Will standardized testing dictate the curriculum in the future? An analysis of major curriculum change indicates two changes in the past 25 years: a revolution within particular content areas (e.g., mathematics and linguistics) and a narrowing of the curriculum to basic skills. Standardized tests seem to r:rercise little influence upon these types of major curricula change. Inferences from historical patterns indicate that testing will exercise little influence on the curriculum in the future. (2) Will test . :overage provide a better match for the curriculum in the future? While the present curriculum-test content match is believed to be quite good, it is hoped that conclusions drawn from present studies will lead to developments in the theory of content validity for multi-level achievement batteries. (3) Will recent developments in testing methodology influence the test-curriculum match? Dielovents in Item Response Theory and Latent Trait Methodology have been shifting interest from curriculum-test content match to trait methodology. The inevitable result of tipping the balance in favor of a trait methodology will be to attenuate the strict fit between curriculum content and test content. (PN)
Polo-Like Kinase 2-Dependent Phosphorylation of NPM/B23 on Serine 4 Triggers Centriole Duplication

Duplication of the centrosome is well controlled during faithful cell division while deregulation of this process leads to supernumary centrosomes, chromosome missegregation and aneuploidy, a hallmark of many cancer cells. We previously reported that Polo-like kinase 2 (Plk2) is activated near the G1/S phase transition, and regulates the reproduction of centrosomes. In search for Plk2 interacting proteins we have identified NPM/B23 (Nucleophosmin) as a novel Plk2 binding partner. We find that Plk2 and NPM/B23 interact in vitro in a Polo-box dependent manner. An association between both proteins was also observed in vivo. Moreover, we show that Plk2 phosphorylates NPM/B23 on serine 4 in vivo in S-phase. Notably, expression of a non-phosphorylatable NPM/B23 S4A mutant interferes with centriole reduplication in S-phase arrested cells and leads to a dilution of centriole numbers in unperturbed U2OS cells. The corresponding phospho-mimicking mutants have the opposite effect and their expression leads to the accumulation of centrioles. These findings suggest that NPM/B23 is a direct target of Plk2 in the regulation of centriole duplication and that phosphorylation on serine 4 can trigger this process.
Topic Models for Meaning Similarity in Context

Recent work on distributional methods for similarity focuses on using the context in which a target word occurs to derive context-sensitive similarity computations. In this paper we present a method for computing similarity which builds vector representations for words in context by modeling senses as latent variables in a large corpus. We apply this to the Lexical Substitution Task and we show that our model significantly outperforms typical distributional methods.
Modeling And Harmonic Analysis Of Domestic / Industrial Loads

This paper discusses the modeling of nonlinear electrical loads used in domestic and small scale industrial distribution systems. Harmonic analysis of the distribution system is essential to study the behavior of equipments connected in the non-sinusoidal system environment for designing and optimal location of filters. Simulation models are developed for various nonlinear loads based on practical waveforms of voltage and current obtained in the laboratory. Analysis of voltage and current harmonics is performed for these loads individually. These models are used for harmonic analysis of typical domestic and industrial loads. Validation of the load models is done by performing case study for an industrial supply system and comparing the THDs obtained from simulation using PSCAD/EMTDC package with the THD values obtained by measurement.
Behavioral and Brain Functions

Background: Individuals with social phobia are more likely to misinterpret ambiguous social situations as more threatening, i.e. they show an interpretive bias. This study investigated whether such a bias also exists in specific phobia. Methods: Individuals with spider phobia or social phobia, spider aficionados and non-phobic controls saw morphed stimuli that gradually transformed from a schematic picture of a flower into a schematic picture of a spider by shifting the outlines of the petals until they turned into spider legs. Participants' task was to decide whether each stimulus was more similar to a spider, a flower or to neither object while EEG was recorded. Results: An interpretive bias was found in spider phobia on a behavioral level: with the first opening of the petals of the flower anchor, spider phobics rated the stimuli as more unpleasant and arousing than the control groups and showed an elevated latent trait to classify a stimulus as a spider and a response-time advantage for spider-like stimuli. No cortical correlates on the level of ERPs of this interpretive bias could be identified. However, consistent with previous studies, social and spider phobic persons exhibited generally enhanced visual P1 amplitudes indicative of hypervigilance in phobia. Conclusion: Results suggest an interpretive bias and generalization of phobia-specific responses in specific phobia. Similar effects have been observed in other anxiety disorders, such as social phobia and posttraumatic stress disorder. Published: 19 November 2007 Behavioral and Brain Functions 2007, 3:59 doi:10.1186/1744-9081-3-59 Received: 12 August 2007 Accepted: 19 November 2007 This article is available from: http://www.behavioralandbrainfunctions. com/content/3/1/59 © 2007 Kolassa et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linking stack overflow to issue tracker for issue resolution

Issue resolution is a central task for software development. The efficiency of issue fixing largely relies on the issue report quality. Stack Overflow, which hosts rich and real-time posts about programming-specific problems, is a valuable external source of knowledge for issue resolution. In this paper, we present CrossLink, an analysis framework that automatically introduce related posts in Stack Overflow to issues in Android Issue Tracker. This helps developers to leverage the abundant and professional knowledge from massive programmers in Stack Overflow for issue resolution. CrossLink explores the semantic similarities as well as the temporal associations between the two types of repositories to recommend Stack Overflow posts to Android issues. The internal links in Stack Overflow are also employed to improve the linking accuracy. The experiments prove the effectiveness of CrossLink with precision of 62.51% for top-10 recommendations, which is significantly higher than the state-of-art method.
Mild cognitive impairment and structural brain abnormalities in a sexagenarian with a history of childhood traumatic brain injury

In this report, we present a case study involving an older, female patient with a history of pediatric traumatic brain injury (TBI). Magnetic resonance imaging and diffusion tensor imaging volumes were acquired from the volunteer in question, her brain volumetrics and morphometrics were extracted, and these were then systematically compared against corresponding metrics obtained from a large sample of older healthy control (HC) subjects as well as from subjects in various stages of mild cognitive impairment (MCI) and Alzheimer disease (AD). Our analyses find the patient's brain morphometry and connectivity most similar to those of patients classified as having early‐onset MCI, in contrast to HC, late MCI, and AD samples. Our examination will be of particular interest to those interested in assessing the clinical course in older patients having suffered TBI earlier in life, in contradistinction to those who experience incidents of head injury during aging.
Prevalence and characteristics of alexithymia in Parkinson's disease.

BACKGROUND Alexithymia, a reduction in the tendency to think about emotions, together with a difficulty in identifying and describing feelings, has been characterized as a personality trait, but may be secondary to other pathological conditions. OBJECTIVE The authors aimed at investigating alexithymia in Parkinson's disease (PD). METHOD Seventy PD patients and 70 control subjects were administered the 20-item Toronto Alexithymia Scale. RESULTS The authors found that 21.4% of PD patients and 10.0% of controls could be classified as alexithymic. PD patients and controls significantly differed on global levels of alexithymia. However, univariate analyses showed that PD patients differed significantly only on the subscale investigating difficulty describing and communicating feelings. CONCLUSION These results indicate that some facets of alexithymia are a relevant feature of PD, possibly in relation to the neuropathological changes that characterize the disease.
Early onset of diabetes mellitus among visible minority and immigrant populations in Canada

Type 2 is a chronic condition that affects nearly over three million Canadians, including immigrants. The timing of the first onset of diabetes has been linked to several other severe ailments such as acute retinopathy, end-renal diseases and micro and macro vascular complications. Yet, there is a dearth of empirical studies that examine the timing of the first onset of diabetes among Canadians, in general, and among immigrants and ethnic minority populations within Canada, in particular. Applying event history techniques (Cox proportional hazards model) to the most recent Canadian Community and Health Survey (CCHS 2013), this study addresses this research void by examining factors that contribute to the first onset of diabetes among immigrant and visible minority populations in Canada (N=8905). Given the gendered patterns in the epidemiology of diseases, and the differences in risk factors for men and women, gender-specific models were estimated. These results showed that South Asian, Black and Filipino women developed diabetes earlier, compared to women from the UK. Similarly, South Asian, Chinese, Filipino, Black, South East Asian and Arab men developed diabetes earlier than men from the UK. A significant and important finding of this analysis was that the risks of developing diabetes earlier in life vanished completely for Black and Filipino women, after accounting for lifestyle factors. This finding implies by modifying behaviors that predispose them to developing this condition, the timing of the onset of diabetes among these ethnic groups could be significantly postponed. Similarly, for South Asian women, there was significant attenuation in their risks after accounting for lifestyle factors. However, the findings were strikingly different for immigrant men. Specifically, their risks of developing diabetes earlier increased after accounting for lifestyle factors. These results suggest the development of gender-specific interventions, targeted at specific immigrant groups with increased risks of developing diabetes earlier in the life course.
An Analytic Comparison of Alpha-False Eye Separation, Image Scaling and Image Shifting in Stereoscopic Displays

Stereoscopic display is a fundamental part of many virtual reality s ystems. Stereoscopic displays render two perspective views of a scene, each of which is seen by one eye of the user. Ideally the user’s natural visual system combines the stereo image pairs and the user perceives a single 3D image. In practice, however, users can have difficulty fusing the st er o image pairs into a single 3D image. Researchers have used a number of software methods t o reduce fusion problems. Some fusion algorithms act directly on the 3D geometry while ot ers act indirectly on the projected 2D images or the view parameters. Compared to the di rect techniques, the indirect techniques tend to alter the projected 2D images to a lesser degree . However while the 3D image effects of the direct techniques are algorithmically speci fied, the 3D effects of the indirect techniques require further analysis. This is important because fusion tech iques were developed in non-head-tracked displays that have distortion properties not found in the mode rn headtracked variety. In non-head-tracked displays, the non-head-tracked distort ion can mask the stereoscopic image artifacts induced by fusion techniques but in head-tra cked displays distracting effects of a fusion technique may become apparent. This paper is concerned with stereoscopic displays in which the head is tracked and the display is s tationary, attached to a desk, tabletop or wall. This paper rigorously and analytically compares the distortion artifacts of three indirect fusion techniques, α-false eye separation, image scaling and image shifting. We
Deep Inspection of the Noise in WiFi Time-of-Flight Echo Techniques

Time-of-flight (ToF) echo techniques have been proposed to estimate the distance between a local and a target station using regular WiFi radio devices. As of today, there is little understanding of the noise sources from ToF measurements. We conduct extensive experimental tests based on a customized WiFi echo technique implementation residing in the core of the 802.11 MAC processor and a high-resolution signal analysis of the WiFi traffic captured with a wideband oscilloscope. We discern the root of the error components in WiFi echo technique measurements and statistically characterize the offset noise added by the target station. Our measurements provide key insights to model the sources of noise and guidance for the design of robust distance estimators.
Acute and chronic pulmonary emboli: angiography-CT correlation.

OBJECTIVE The objective of our study was to review the classic direct and indirect angiographic signs of acute and chronic pulmonary embolism (PE) and correlate these findings with MDCT. CONCLUSION CT and angiography have complementary roles in the accurate diagnosis of acute and chronic thromboembolic disease. Conventional angiography should be used as a problem-solving technique after CT angiography has been performed because CT angiography is less invasive.
Changing Organizational Designs and Performance Frontiers

This paper develops and tests a multilevel organizational contingency theory for designing headquarters–subsidiary relations. We use frontier analysis to overcome problems that have hampered advancements in organizational contingency theory in general and headquarters–subsidiary relationships in particular. Based on a longitudinal study of a large medical group practice of 32 local community clinics, we compute the relative distance of clinics from a best-performance frontier, determine what proportions of changes in clinic performance are due to factors that are endogenous or exogenous to the clinics, and examine the organizational factors that may explain these performance changes. We find that uniform headquarters policies have differing effects on the performance of subsidiary units, benefiting some and hindering others through no fault of their own. We also find significant performance volatility with different types of unit designs, suggesting the need to examine the risks of changing organization designs.
Compound treatments, transportability, and the structural causal model: the power and simplicity of causal graphs.

I n “Compound treatments and transportability of causal inference” in this issue of E PIDEMIOLOGY , Herna´n and VanderWeele (H&V) 1 argue that causal analyses often fail to specify a causal question that adequately addresses the motivating policy issue. H&V highlight the issue of “compound treatments,” or treatments with multiple versions. An example used by H&V is an intervention to prevent obesity. They discuss how compound treatments can result in ill-deﬁned counterfactuals, complicate the articulation and evaluation of the consistency assumption
The Role of Innate APOBEC3G and Adaptive AID Immune Responses in HLA-HIV/SIV Immunized SHIV Infected Macaques

The AID/APOBEC family (activation induced deaminase/apolipoprotein B mRNA editing cytokine deaminase) in B cells play important roles in adaptive and innate immunity. Whereas APOBEC3G has been studied in CD4+ T cells and myeloid cells its functional potential in B cells has received little attention. AID combines two critical functions of antibodies, class switching and affinity maturation and may serve as a functional surrogate of protection. These functions were studied following systemic immunization of rhesus macaques with recombinant HLA constructs, linked with HIV and SIV antigens and HSP70 to dextran. The results showed significant upregulation of AID in CD20+ B cells, APOBEC 3G in CD27+ memory B cells and CD4+ effector memory T cells. After immunization the upregulated APOBEC 3G and AID were directly correlated in B cells (p<0.0001). Following challenge with SHIV SF162.P4 the viral load was inversely correlated with AID in B cells and APOBEC 3G in B and T cells, suggesting that both deaminases may have protective functions. Investigation of major interactions between DC, T cells and B cells showed significant increase in membrane associated IL-15 in DC and CD40L in CD4+ T cells. IL-15 binds the IL-15 receptor complex in CD4+ T and B cells, which may reactivate the DC, T and B cell interactions. The overall results are consistent with AID inhibiting pre-entry SHIV by eliciting IgG and IgA antibodies, whereas APOBEC 3G may contribute to the post-entry control of SHIV replication and cellular spread.
Products of Experts

Note thatMixture of Expert Modelsare usually associated with conditional models where the experts are of the formp(y|x) and the mixture coefficients (known as gating functions) may depend on x as well, α(x). Conditional PoEs may be defined as well. One can qualitatively understand the difference between mixtures and products by observing that a mixture distribution can have high probability for event x when only a single expert assigns high probability to that event. In contrast, a product can only have high probability for an event x when all experts assign high probability to that event. Hence, metaphorically speaking, a single expert in a mixture has the power to pass a bill while a single expert in a product has the power to veto it. Put another way, each component in a product represents a soft constraint , while each expert in a mixture represents a soft template or prototype. For an event to be likely under a product model, all constraints must
An Overview of e-Health in Indonesia: Past and Present Applications

Indonesia is the largest archipelagic country in the world. There are five major islands and thousands of smaller islands, most of which are in the distance. Therefore, its health services are hardly distributed. E-Health is one of the methods expected to deal with the problem of distance in health services. The development and use of technology in health area has given rise to several studies on the applications of e-Health in Indonesia. Based on a number of studies, we find that e-Health in Indonesia has been applied since 1985. The technologies and features used from time to time were growing in some period of time. However, the study also shows that from that point of time the number and variety of technologies and features provided are decreasing and the focus shifted to further analysis of the problems needed to be solved and provision of technologies and features only relevant to those problems. The development of e-Health applications in Indonesia has given promising results in providing health services, but they are still conducted by certain educational institutions and their uses are not evenly distributed throughout Indonesia.