Miracle-dz/UniFAR-FTUs huggingface dataset:
A three-part input-output clustering-based approach to fuzzy system identification

This article presents a clustering-based approach to fuzzy system identification. In order to construct an effective initial fuzzy model, this article tries to present a modular method to identify fuzzy systems based on a hybrid clustering-based technique. Moreover, the determination of the proper number of clusters and the appropriate location of clusters are one of primary considerations on constructing an effective initial fuzzy model. Due to the above reasons, a hybrid clustering algorithm concerning input, output, generalization and specialization has hence been introduced in this article. Further, the proposed clustering technique, three-part input-output clustering algorithm, integrates a variety of clustering features simultaneously, including the advantages of input clustering, output clustering, flat clustering, and hierarchical clustering, to effectively perform the identification of clustering problem.
The Place Code of Saccade Metrics in the Lateral Bank of the Intraparietal Sulcus

The lateral intraparietal area (LIP) of monkeys is known to participate in the guidance of rapid eye movements (saccades), but the means it uses to specify movement variables are poorly understood. To determine whether area LIP devotes neural space to encode saccade metrics spatially, we used the quantitative [14C]deoxyglucose method to obtain images of the distribution of metabolic activity in the intraparietal sulcus (IPs) of rhesus monkeys trained to repeatedly execute saccades of the same amplitude and direction for the duration of the experiment. Different monkeys were trained to perform saccades of different sizes and in different directions. A clear topography of saccade metrics was found in the cytoarchitectonically identified area LIP ventral (LIPv) contralateral to the direction of the eye movements. We demonstrate that the representation of the vertical meridian runs parallel to the fundus of the IPs and that it is not orthogonal to the representation of the horizontal meridian. Instead, the latter runs through the middle of LIPv parallel to its border with area LIP dorsal (LIPd). The upper part of oculomotor space is represented rostrally and dorsally relative to the horizontal meridian toward the LIPv–LIPd border, whereas the lower part of oculomotor space is represented caudally and ventrally toward the caudal edge of the IPs. Saccade amplitude is also represented in an orderly manner.
Parts Obsolescence Challenges for the Electronics Industry

The lifetime of electronic parts has decreased over the years. The result is that companies designing embedded systems with long life-time would have problems. Thus, there are problems with manufacturing the products for as many years as they would like to as well as being able to provide spare parts for customers. To be able to analyze the extent of the problem as well as learning about how the industry copes with the problem, we have conducted a survey among the foremost Norwegian original equipment manufacturer (OEM) companies and contract manufacturers. This paper presents the main observations from this survey. The main conclusion from the survey is that obsolescence is a problem but the extent of it depends on how much proactive focus a company has. The companies taking precautions would benefit from that by extending the time span before they have to redesign their systems.
Parallel Genetic and Proteomic Screens Identify Msps as a CLASP–Abl Pathway Interactor in Drosophila

Regulation of cytoskeletal structure and dynamics is essential for multiple aspects of cellular behavior, yet there is much to learn about the molecular machinery underlying the coordination between the cytoskeleton and its effector systems. One group of proteins that regulate microtubule behavior and its interaction with other cellular components, such as actin-regulatory proteins and transport machinery, is the plus-end tracking proteins (MT+TIPs). In particular, evidence suggests that the MT+TIP, CLASP, may play a pivotal role in the coordination of microtubules with other cellular structures in multiple contexts, although the molecular mechanism by which it functions is still largely unknown. To gain deeper insight into the functional partners of CLASP, we conducted parallel genetic and proteome-wide screens for CLASP interactors in Drosophila melanogaster. We identified 36 genetic modifiers and 179 candidate physical interactors, including 13 that were identified in both data sets. Grouping interactors according to functional classifications revealed several categories, including cytoskeletal components, signaling proteins, and translation/RNA regulators. We focused our initial investigation on the MT+TIP Minispindles (Msps), identified among the cytoskeletal effectors in both genetic and proteomic screens. Here, we report that Msps is a strong modifier of CLASP and Abl in the retina. Moreover, we show that Msps functions during axon guidance and antagonizes both CLASP and Abl activity. Our data suggest a model in which CLASP and Msps converge in an antagonistic balance in the Abl signaling pathway.
Correlation Between DNase I Hypersensitive Site Distribution and Gene Expression in HeLa S3 Cells

Mapping DNase I hypersensitive sites (DHSs) within nuclear chromatin is a traditional and powerful method of identifying genetic regulatory elements. DHSs have been mapped by capturing the ends of long DNase I-cut fragments (>100,000 bp), or 100–1200 bp DNase I-double cleavage fragments (also called double-hit fragments). But next generation sequencing requires a DNA library containing DNA fragments of 100–500 bp. Therefore, we used short DNA fragments released by DNase I digestion to generate DNA libraries for next generation sequencing. The short segments are 100–300 bp and can be directly cloned and used for high-throughput sequencing. We identified 83,897 DHSs in 2,343,479 tags across the human genome. Our results indicate that the DHSs identified by this DHS assay are consistent with those identified by longer fragments in previous studies. We also found: (1) the distribution of DHSs in promoter and other gene regions of similarly expressed genes differs among different chromosomes; (2) silenced genes had a more open chromatin structure than previously thought; (3) DHSs in 3′untranslated regions (3′UTRs) are negatively correlated with level of gene expression.
Anti-angiogenic and antitumor activities of Huaier aqueous extract

Traditional Chinese medicine, a rich source of potent cancer chemopreventive agents, is attracting increasing attention worldwide. Recently, the anticancer activity of Trametes robiniophila Murr. (Huaier) has been widely investigated. However, the mechanisms are not yet fully understood. This study aimed to elucidate the inhibitory effect of Huaier extract on angiogenesis and tumor growth. Incubation with Huaier extract inhibited the proliferation of human umbilical vein endothelial cells (HUVECs) and mouse mammary tumor cells (4T1). In addition, treatment with Huaier extract decreased the motility and tube formation of HUVECs in a dose-dependent manner in vitro. As determined by western blot analysis, Huaier extract dose-dependently decreased the levels of phosphorylated extracellular signal-regulated kinase (ERK), transcription factor p65, c-Jun N-terminal kinase (JNK), signal transducer and activator of transcription 3 (STAT3) and the expression of vascular endothelial growth factor (VEGF). In ex vivo experiments, new vessel growth was suppressed as shown by chick embryo chorioallantoic membrane (CAM) and rat aortic ring assays in the presence of Huaier extract. To further evaluate the inhibitory effect, 4T1 cells were injected subcutaneously into BALB/c mice. The administration of Huaier extract suppressed tumor volume, decreased microvessel density and induced apoptosis. These data suggest that Huaier extract may serve as a potent anti-angiogenic and antitumor agent.
Reprogramming of Fibroblasts From Older Women With Pelvic Floor Disorders Alters Cellular Behavior Associated With Donor Age

We aimed to derive induced pluripotent stem cell (iPSC) lines from vaginal fibroblasts from older women with pelvic organ prolapse. We examined the effect of donor age on iPSCs and on the cells redifferentiated from these iPSCs. Vaginal fibroblasts were isolated from younger and older subjects for reprogramming. iPSCs were generated simultaneously using an excisable polycistronic lentiviral vector expressing Oct4, Klf4, Sox2, and cMyc. The pluripotent markers of iPSCs were confirmed by immunocytochemistry and quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR). Spectral karyotyping was performed. The ability of the iPSCs to differentiate into three germ layers was confirmed by embryoid body and teratoma formation. Senescence marker (p21, p53, and Bax) expressions were determined by qRT‐PCR and Western blot. The iPSCs were redifferentiated to fibroblasts and were evaluated with senescence‐associated β‐galactosidase (SA) activity and mitotic index using time‐lapse dark‐field microscopy. iPSCs derived from both the younger and older subjects expressed pluripotency markers and showed normal karyotype and positive teratoma assays. There was no significant difference in expression of senescence and apoptosis markers (p21, p53, and Bax) in iPSCs derived from the younger subject compared with the older subject. Furthermore, fibroblasts redifferentiated from these iPSCs did not differ in SA activity or mitotic index. We report successful derivation of iPSCs from women with pelvic organ prolapse. Older age did not interfere with successful reprogramming. Donor age differences were not observed in these iPSCs using standard senescence markers, and donor age did not appear to affect cell mitotic activity in fibroblasts redifferentiated from iPSCs.
Adapting Standard Open-Source Resources To Tagging A Morphologically Rich Language: A Case Study With Arabic

In this paper we investigate the possibility of creating a PoS tagger for Modern Standard Arabic by integrating open-source tools. In particular a morphological analyser, used in the disambiguation process with a PoS tagger trained on classical Arabic. The investigation shows the scarcity of open-source tools and resources, which complicated the integration process. Among the problems are different input/output formats of each tool, granularity of tag sets and different tokenisation schemes. The final prototype of the PoS tagger was trained on classical Arabic and tested on a sample text of modern standard Arabic. The results are not that impressive, only an accuracy of 73% is achieved. This paper however outlines the difficulties of integrating tools today and proposes ideas for future work in the field and shows that classical Arabic is not sufficient as training data for an Arabic tagger.
Development of lateral control module for zone(u-turn) maneuver of vehicle/driver cooperative autonomous driving system

This paper proposes a lateral control module for zone(u-turn) maneuver of vehicle/driver cooperative autonomous driving system. The lateral control module consists of the path tracker and primitive driver. The path tracker is using the two sub path tracker according to maneuver of local path planner of the Co-Pilot agent block. And it generates target steering angle by using local path information, current vehicle position and azimuth information from the agent block. The primitive driver controls steering actuator to follow the command steering angle. We propose Stanley algorithm for generating target steering angle, and apply the yaw damping algorithm for increasing yaw stability at zone maneuver. The primitive driver controls steering actuator by using PID (Proportional-Integral-Derivative) controller and compensator. We verified the lateral control module for zone(u-turn) maneuver through experimental test by using Co-Pilot system vehicle.
DeLLIS: A Data Mining Process for Fault Localization

Most fault localization methods aim at totally ordering program elements from highly suspicious to innocent. This ignores the structure of the program and creates clusters of program elements where the relations between the elements are lost. We propose a data mining process that computes program element clusters and that also shows dependencies between program elements. Experimentations show that our process gives a comparable number of lines to analyze than the best related methods while providing a richer environment for the analysis. We also show that the method scales up by tuning the statistical indicators of the data mining process.
Programming human-like point-to-point approaching movement by demonstrations with Large-Scale Direct Monocular SLAM

With the development of robotic technologies over last decades, the robotic mapping or the simultaneous localization and mapping (SLAM) has got matured correspondingly. The Large-Scale Direct Monocular SLAM (LSD-SLAM) is among the most promising methods in SLAM, which not only locally tracks the motion of the camera, but allows to build consistent and large-scale maps of the environment. In this paper, LSD-SLAM is implemented to model the surrounding environment of a three degrees-of-freedom robot manipulator. All the objects in the robot workspace have been recognized and located. And the robot will take the extracted information as visual input to perform a point-to-point approaching task A novel motion planning technique, programming by demonstrations (PbD), is used to transfer human approaching skills to the robot. Gaussian Mixture Models (GMM) and Gaussian Mixture Regression (GMR) are used to encode human demonstrations with a first-order differential dynamical systems model. Experimental results have verified the effectiveness of the proposed methods.
Diagnostic utility of dermatoscopy in hydroquinone‐induced exogenous ochronosis

Background Hydroquinone is the preferred topical bleaching agent used in the treatment of melasma. The adverse effects of its chronic use are confetti‐like depigmentation and exogenous ochronosis. Exogenous ochronosis manifests clinically with gray‐brown or blue‐black hyperpigmentation, as well as pinpoint hyperchromic caviar‐like papules over the malar region. Dermatoscopic findings of ochronosis are unique and point towards a clue for its diagnosis.
Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study.

RATIONALE The pattern of IgE response (over time or to specific allergens) may reflect different atopic vulnerabilities which are related to the presence of asthma in a fundamentally different way from current definition of atopy. OBJECTIVES To redefine the atopic phenotype by identifying latent structure within a complex dataset, taking into account the timing and type of sensitization to specific allergens, and relating these novel phenotypes to asthma. METHODS In a population-based birth cohort in which multiple skin and IgE tests have been taken throughout childhood, we used a machine learning approach to cluster children into multiple atopic classes in an unsupervised way. We then investigated the relation between these classes and asthma (symptoms, hospitalizations, lung function and airway reactivity). MEASUREMENTS AND MAIN RESULTS A five-class model indicated a complex latent structure, in which children with atopic vulnerability were clustered into four distinct classes (Multiple Early [112/1053, 10.6%]; Multiple Late [171/1053, 16.2%]; Dust Mite [47/1053, 4.5%]; and Non-dust Mite [100/1053, 9.5%]), with a fifth class describing children with No Latent Vulnerability (623/1053, 59.2%). The association with asthma was considerably stronger for Multiple Early compared with other classes and conventionally defined atopy (odds ratio [95% CI]: 29.3 [11.1-77.2] versus 12.4 [4.8-32.2] versus 11.6 [4.8-27.9] for Multiple Early class versus Ever Atopic versus Atopic age 8). Lung function and airway reactivity were significantly poorer among children in Multiple Early class. Cox regression demonstrated a highly significant increase in risk of hospital admissions for wheeze/asthma after age 3 yr only among children in the Multiple Early class (HR 9.2 [3.5-24.0], P < 0.001). CONCLUSIONS IgE antibody responses do not reflect a single phenotype of atopy, but several different atopic vulnerabilities which differ in their relation with asthma presence and severity.
Direct measurement of the bulk spin structure of noncentrosymmetric BiTeCl

A strong spin-orbit interaction leads to a Rashba-type splitting of the bulk bands of BiTeCl, which results in toroidal Fermi surfaces with distinct spin structures depending on the chemical potential. Here, we present spin-and angle-resolved photoelectron spectroscopy measurements of the three-dimensional spin-orbit split state at the top of the valence band. Its polarization is systematically studied in dependence of the photon energy and compared to ab initio calculations of the initial state. The measured spin orientation is in plane to the (0001) surface and perpendicular to the momentum, independently of the photon energy.
Two-Point Coordinate Rings for GK-Curves

Giulietti and Korchmáros presented new curves with the maximal number of points over a field of size q6. Garcia, Güneri, and Stichtenoth extended the construction to curves that are maximal over fields of size q2n, for odd n ≥ 3. The generalized GK-curves have affine equations xq+x = yq+1 and yq2-y = zr, for r=(qn+1)/(q+1). We give a new proof for the maximality of the generalized GK-curves and we outline methods to efficiently obtain their two-point coordinate ring.
Music Composition from the Brain Signal: Representing the Mental State by Music

This paper proposes a method to translate human EEG into music, so as to represent mental state by music. The arousal levels of the brain mental state and music emotion are implicitly used as the bridge between the mind world and the music. The arousal level of the brain is based on the EEG features extracted mainly by wavelet analysis, and the music arousal level is related to the musical parameters such as pitch, tempo, rhythm, and tonality. While composing, some music principles (harmonics and structure) were taken into consideration. With EEGs during various sleep stages as an example, the music generated from them had different patterns of pitch, rhythm, and tonality. 35 volunteers listened to the music pieces, and significant difference in music arousal levels was found. It implied that different mental states may be identified by the corresponding music, and so the music from EEG may be a potential tool for EEG monitoring, biofeedback therapy, and so forth.
Performance Study of Untrusted Relay Network Utilizing Cooperative Jammer

93 AIJ Electrical & Electronics Engineering, Vol 48, No. 2, Fall 2016 Please cite this article using: Kuhestani, A. , Mohammadi, A. , and Emadi, M. J., 2016. “Performance Study of Untrusted Relay Network Utilizing Cooperative Jammer”. Amirkabir International Journal of Electrical and Electronics Engineering, 48(2), pp. 93–99. DOI: 10.22060/eej.2016. 820 URL: http://eej.aut.ac.ir/article_820. html *Corresponding Author, Email: abm125@aut.ac.ir Performance Study of Untrusted Relay Network Utilizing Cooperative Jammer
Autism and Overcoming Job Barriers: Comparing Job-Related Barriers and Possible Solutions in and outside of Autism-Specific Employment

The aim of this study was to discover how individuals with autism succeed in entering the job market. We therefore sought to identify expected and occurred barriers, keeping them from taking up and staying in employment as well as to identify the solutions used to overcome these barriers. Sixty-six employed individuals with autism–17 of them with autism-specific employment–participated in an online survey. Results showed a variety of possible barriers. Individuals in autism-specific employment named formality problems–problems with organizational and practical process-related aspects of the job entry–most frequently while individuals in non-autism-specific employment mentioned social problems–obstacles concerning communication and human interaction–most. In terms of solutions, both groups used their own resources as much as external help, but differed in their specific strategies. In addition, correlations of an autism-specific employment with general and occupational self-efficacy as well as life and job satisfaction were examined. Possible implications of the results are discussed with regard to problem solving behavior and the use of strengths.
Plasma Aβ42 and Aβ40 as markers of cognitive change in follow-up: a prospective, longitudinal, population-based cohort study

Background Single measurements of plasma Aβ are not useful in the diagnostics of Alzheimer's disease (AD). However, changes in plasma Aβ levels during repeated testing may be helpful in the prediction and evaluation of progression of the incipient AD or mild cognitive impairment. Objective To examine the relation of baseline and serial plasma Aβ levels to cognitive change in follow-up. Methods 269 subjects (52 cognitively impaired and 217 controls) from a population-based cohort were clinically followed up from 3 to 6 years. Serial plasma samples were available from 70 subjects who were followed up for 3 years and 43 subjects followed for 6 years. The plasma Aβ levels were measured using ELISA. Results Subjects who declined cognitively during the follow-up had lower levels of plasma Aβ42 at the baseline. Plasma Aβ42 and the Aβ42/Aβ40 ratio decreased (−2.4 pg/ml for Aβ42 in 6 years) in those who declined in follow-up, whereas Aβ42 and the Aβ42/Aβ40 ratio increased in the subjects who remained cognitively stable or improved in follow-up. Subjects using acetylsalicylic acid, dipyridamole, antidiabetic or anticoagulant drugs as well as subjects with coronary heart disease had higher levels of Aβ40. Conclusions Low or decreasing plasma Aβ42 during the follow-up is associated with cognitive decline. Serial measurement of plasma Aβ42 may be useful in the detection of the subjects who are at risk for cognitive decline.
How to Maximally Support Local and Regional Biodiversity in Applied Conservation? Insights from Pond Management

Biodiversity and nature values in anthropogenic landscapes often depend on land use practices and management. Evaluations of the association between management and biodiversity remain, however, comparatively scarce, especially in aquatic systems. Furthermore, studies also tend to focus on a limited set of organism groups at the local scale, whereas a multi-group approach at the landscape scale is to be preferred. This study aims to investigate the effect of pond management on the diversity of multiple aquatic organism groups (e.g. phytoplankton, zooplankton, several groups of macro-invertebrates, submerged and emergent macrophytes) at local and regional spatial scales. For this purpose, we performed a field study of 39 shallow man-made ponds representing five different management types. Our results indicate that fish stock management and periodic pond drainage are crucial drivers of pond biodiversity. Furthermore, this study provides insight in how the management of eutrophied ponds can contribute to aquatic biodiversity. A combination of regular draining of ponds with efforts to keep ponds free of fish seems to be highly beneficial for the biodiversity of many groups of aquatic organisms at local and regional scales. Regular draining combined with a stocking of fish at low biomass is also preferable to infrequent draining and lack of fish stock control. These insights are essential for the development of conservation programs that aim long-term maintenance of regional biodiversity in pond areas across Europe.