Miracle-dz/UniFAR-FTUs huggingface dataset:
Genome Sequence of Pseudomonas stutzeri SDM-LAC, a Typical Strain for Studying the Molecular Mechanism of Lactate Utilization

ABSTRACT Pseudomonas stutzeri SDM-LAC is an efficient lactate utilizer with various applications in biocatalysis. Here we present a 4.2-Mb assembly of its genome. The annotated four adjacent genes form a lactate utilization operon, which could provide further insights into the molecular mechanism of lactate utilization.
Training rather than walking: the test in -train out program for home-based rehabilitation in peripheral arteriopathy.

BACKGROUND Exercise training reduces walking disability in peripheral arterial disease (PAD). This non-randomized study evaluates the effects on walking ability and hemodynamic parameters of a novel approach to home-based rehabilitation, the test in -train out program (Ti-To), compared with the traditional home-based free walking exercise (Tr-E). METHODS AND RESULTS A total of 143 patients with claudication (117 men, average age 68+/-10 years), were included in a Ti-To (n=83) or Tr-E program (n=60). Evaluations, which were carried out upon entry and at 1, 2, 3, 4 and 6 months, included: self-reported claudication, walking ability (ie, absolute claudication distance, pain threshold speed), resting/exercise heart rates (HR), systolic/diastolic brachial pressure (SBP/DBP), ankle pressure (AP), ankle-brachial index (ABI). Ti-To involved 2 daily 10-min home walking sessions at maximal asymptomatic speed and the patient attending monthly check-ups at hospital. Tr-E involved 20-30 min of daily walking at self-selected speeds up to pain tolerance. A total of 126 patients (Ti-To, n=74; Tr-E, n=52) completed the program. Ti-To induced better relief from claudication (p=0.001). Functional parameters improved significantly for both groups (p<0.0001) with significant intergroup difference for Ti-To (p<0.0001). SBP and exercise HR decreased significantly in both groups, with Ti-To improving resting HR (p=0.0002), DBP (p=0.003), lowest AP worse limb (p=0.004) and ABI worse limb (p=0.0002). CONCLUSIONS In patients with PAD, a Ti-To program had more positive effects on perceived claudication, and functional and hemodynamic parameters than did a Tr-E program.
Physical Activity Promotion Among Underserved Adolescents: “Make It Fun, Easy, and Popular”

There is a paucity of studies regarding noncurricular physical activity promotion interventions among adolescents, and even less such research pertaining to underserved youth. This article describes the development and implementation of a noncurricular, school-based physical activity promotion program designed for a multiethnic, underserved population of adolescents. The program’s impact on leisure-time physical activity (LTPA) and on physical activity enjoyment (PAE) is also presented. The 16-week program, named FunAction, utilizes social marketing principles. Control (n = 90) and intervention (n = 131) students are assessed pre- and postintervention for levels of LTPA and PAE. Results indicate that although the program did not contribute to an increase in LTPA or PAE among intervention group students, participation in the program was elevated. This study offers preliminary evidence that noncurricular physical activity promotion programs that apply social marketing principles can be effective in engaging multiethnic, underserved adolescents in physical activity.
An Exploration of Enterprise Architecture Research

Management of the enterprise architecture has become increasingly recognized as a crucial part of both business and IT management. Still, a common understanding and methodological consistency seems far from being developed. Acknowledging the significant role of research in moving the development process along, this article employs different bibliometric methods, complemented by an extensive qualitative interpretation of the research field, to provide a unique overview of the enterprise architecture literature. After answering our research questions about the collaboration via co-authorships, the intellectual structure of the research field and its most influential works, and the principal themes of research, we propose an agenda for future research based on the findings from the above analyses and their comparison to empirical insights from the literature. In particular, our study finds a considerable degree of co-authorship clustering and a positive impact of the extent of co-authorship on the diffusion of works on enterprise architecture. In addition, this article identifies three major research streams and shows that research to date has revolved around specific themes, while some of high practical relevance receive minor attention. Hence, the contribution of our study is manifold and offers support for researchers and practitioners alike.
FUZZY BASED DECISION MAKING FOR PROMOTIONAL MARKETING CAMPAIGNS

Fuzzy logic starts with the introduction of a fuzzy set. A fuzzy set is a set in which the boundary is not precisely defined. It can contain elements with only a certain degree of membership. This paper presents a prediction of selection of customers for promotional marketing campaigns by incorporating fuzzy approach. A fuzzy model is proposed for selection of customers who should be targeted for deposit subscription schemes. Selection criteria are formulated on the basis of customer’s loan balance, customer’s age and annual income. Fuzzy logic approach is used for decision making for targeting specific customers for subscription.
The Experiential Analysis on Chinese High-tech Industries and Other Associated Industries Effects

Based on input-output theory and industry relevance theory, this paper re-integrates Chinese 2002 input-output table of 2001~2005 by input-output model. Then it estimates a series of economic parameters, including the direct consumption coefficient, sensitivity coefficients and influence coefficient. After quantitative analysis of the high-tech industries and other sectors of the national economy between the association effects, it classifies and analyzes its association effects. It finds out that the association effects between the high-tech industries and related industrial sectors, and the proportion of its affecting degree.
Why Civil Service Reforms do not Work

Public sector reform (PSR) efforts in developing countries have been less than successful in the past. Motivated by budgetary considerations, they have focused on downsizing and procedural changes without radically altering the outmoded incentive system, which, in many countries, is now characterised by declining real wages, wage compression, and a non-merit promotion and reward system. Using results from the incentives literature, this paper argues that, for a reform effort to succeed, public sector human resource management (HRM) will have to be reformed at an early stage to establish productivity incentives in the public sector. These will include introducing substantial autonomy to organisations in their work, incentive schemes, and HRM along the lines of the now well-accepted concept of central bank independence. Past PSR efforts have also attempted to conduct a unified reform effort led centrally by the ministry of finance. A continuous process like PSRspread out over a considerable period and involving many different people and organisationsmight need to build in decentralisation, local leadership and local incentives, and HRM. PSR must be based on the recognition that people are at the heart of public service. As a result, managing human resources must be at the centre of any effort. The people who are at the center of this change can either be its architects and beneficiaries or its losers and therefore opponents of change. Design and implementation of reforms must, therefore, be sensitive to this important fact. It is essential that the reform is led by individuals at the organisation level who understand the vision as well as process of change. Governments must empower such leadership to guide, initiate, innovate, and manage change.
Golden Hours in Severe Paraquat Poisoning-The Role of Early Haemoperfusion Therapy.

INTRODUCTION Paraquat is a commonly ingested poison especially in Southern India. There is no antidote for paraquat poison and consumption is often fatal. The usual cause of death is either acute lung injury or multi-organ failure. AIM To evaluate the role of early haemoperfusion as a therapy in paraquat poisoned patients. MATERIALS AND METHODS This study was a retrospective analysis of patients admitted to a Tertiary Medical College Hospital between January 2012 and December 2015 with history of paraquat consumption, comparing outcomes in those who received only gastric lavage and symptomatic treatment with those who received haemoperfusion as a therapy. The role of early haemoperfusion (≤ 6 hours) vs late haemoperfusion (> 6 hours) in paraquat poisoned patients was also compared. The data of these patients was extracted and analysed with respect to age, sex, mode of treatment, the outcome in patients who received early and late haemoperfusion. RESULTS A total of 101 patients were studied out of which 62 died. Deaths were more in those patients who received only gastric lavage with symptomatic treatment as therapy compared to those who received haemoperfusion i.e., 92.1% vs 42.9% respectively. We also found that, the survival rate was better in patients who received early haemoperfusion. CONCLUSION Early haemoperfusion was helpful in the management of severe paraquat poisoning and improved the survival rate in these patients.
Resolving the Paradox of Interdependency and Strategic Renewal in Activity Systems

We examine an intriguing paradox regarding whether interdependencies in an organization's activity system enable or hinder strategic renewal—the incremental process through which an organization continuously adapts to the environment and explores opportunities to invoke change in its activity choices and outputs. One research stream, the “inertial view,” argues that the pervasiveness of interdependencies among activities increases inertia, which inhibits strategic renewal. Another research stream, the “adaptive view,” argues that the pervasiveness of interdependencies among activities allows for a rich flow of resources and information, which enables strategic renewal. In this article we argue that both views provide important insights but arrive at conflicting conclusions because they focus on different dimensions of interdependency. To resolve this paradox, we distinguish between an activity system's interdependency patterns and interdependency rules. We propose that the dimensions of the interdependenc.
The role of ultrasonography in assessing disease activity in patients with rheumatoid arthritis and associated fibromyalgia.

AIM The purpose of this study is to compare and correlate US evaluation with clinical scores of the disease activity in patients with rheumatoid arthritis (RA) and concomitant fibromyalgia (FM). MATERIAL AND METHODS Ten patients diagnosed with RA according to the 2010 ACR/EULAR classification criteria and associated FM based on the ACR 1990 classification criteria and two control groups, one with RA (10 patients) and one with FM (10 patients), were included. Clinical assessment was performed and the disease activity scores were calculated. Synovial/tenosynovial hypertrophy, fluid collections in grey scale (GS), and Power Doppler (PD) US assessed by US in the 28 joints included in the disease activity score 28 (DAS28). RESULTS GS US score and PD US scores were correlated with DAS28 only in patients with RA (Pearson r coefficients 0.3 and 0.5). Mean DAS28 score was significantly higher in the RA/FM group, compared to RA and FM (5.6 versus 4.6 versus 4.5, respectively). Patients with RA/FM had similar median US scores to RA patients, while in FM group significantly lower median US scores were detected (16 versus 9.5 versus 0 for GS US and 3.5 versus 1.5 versus 0 for PD US, respectively). CONCLUSIONS Disease activity scores should be interpreted with caution in patients with RA and FM. When available, US should be used to guide treatment decisions in patients with RA and FM.
The Small GTPase Rap1 Is Required for Mn2+- and Antibody-induced LFA-1- and VLA-4-mediated Cell Adhesion*

In T-lymphocytes the Ras-like small GTPase Rap1 plays an essential role in stimulus-induced inside-out activation of integrin LFA-1 (αLβ2) and VLA-4 (α4β1). Here we show that Rap1 is also involved in the direct activation of these integrins by divalent cations or activating antibodies. Inhibition of Rap1 either by Rap GTPase-activating protein (RapGAP) or the Rap1 binding domain of RalGDS abolished both Mn2+- and KIM185 (anti-LFA-1)-induced LFA-1-mediated cell adhesion to intercellular adhesion molecule 1. Mn2+- and TS2/16 (anti-VLA-4)-induced VLA-4-mediated adhesion were inhibited as well. Interestingly, both Mn2+, KIM185 and TS2/16 failed to induce elevated levels of Rap1GTP. These findings indicate that available levels of GTP-bound Rap1 are required for the direct activation of LFA-1 and VLA-4. Pharmacological inhibition studies demonstrated that both Mn2+- and KIM185-induced adhesion as well as Rap1-induced adhesion require intracellular calcium but not signaling activity of the MEK-ERK pathway. Moreover, functional calmodulin signaling was shown to be a prerequisite for Rap1-induced adhesion. From these results we conclude that in addition to stimulus-induced inside-out activation of integrins, active Rap1 is required for cell adhesion induced by direct activation of integrins LFA-1 and VLA-4. We suggest that Rap1 determines the functional availability of integrins for productive binding to integrin ligands.
The effect of increased lipoprotein levels on the pharmacokinetics of cyclosporine A in the laboratory rat

The response of cyclosporine A (CyA) blood concentrations following changes in lipoprotein levels have been inconsistent. Some studies show increases in concentrations, whereas others have shown decreases. The intent of this study was to examine the effect of two rat models of increased lipoprotein on the pharmacokinetics of CyA. One was a simulated high fat content meal, in which 1% cholesterol in peanut oil was administered. The other was the poloxamer 407‐induced model of hyperlipidemia. Rats in these two groups were compared to a group fasted overnight before the study. In rats given a simulated high fat meal, at most time points the mean blood and plasma concentrations were lower, though not significantly, compared to fasted animals. Oral lipid led to no significant changes in the measured pharmacokinetic parameters of blood or plasma area under the concentration vs time curve (AUC), clearance (CL), volume of distribution (Vd) or plasma unbound fraction. In the poloxamer 407‐treated hyperlipidemic rats there were significant reductions in plasma unbound fraction plasma, Vd and terminal half‐life, but not AUC or CL, compared to normolipidemic rats. In contrast, the CL, Vd and t1/2 in the oral lipid‐fed rats were all significantly higher than the poloxamer 407 treated animals. Oral absolute bioavailability of CyA was unchanged by oral lipid. In humans and rats the pharmacokinetics of CyA in the face of increased lipoprotein levels do not correspond well to what is typically seen for other drugs that are known to bind to lipoproteins. Copyright © 2005 John Wiley & Sons, Ltd.
The avatar lecturer: learning and teaching in Second Life

Purpose – This paper aims to give the educator's perspective on developing learning and teaching activities within the virtual world Second Life (SL). The purpose of the research was to develop an understanding of the pedagogical issues involved, to introduce avatar‐based marketing into the marketing curriculum, and to evaluate the potential for this new technology to enhance student learning.Design/methodology/approach – The issues educators need to address in setting up such activities are considered, including context, design and pedagogical issues. It was decided to take an experiential learning approach following exploratory research. A mixed methods approach allowed the collection of quantitative data to profile the cohort and qualitative data to provide rich data of both the student and educators experience.Findings – There is a steep learning curve for educators developing such courses particularly as subject specialists rather than computing specialists. Students developed new skills, used knowle.
The relationship of service provider power motivation, empowerment and burnout to customer satisfaction

Purpose – Burnout, which is caused by chronic stress, is common in the service professions and has a negative effect, both on the service provider's job performance and customer satisfaction. Empowerment is a potential buffer against the stress involved in service roles, but its advantages may depend on the service provider's desire to be empowered. The study examines several interactive effects of empowerment and seeking power on service provider burnout. In addition, the study examined the relationship between service providers' burnout and customers' reports of their satisfaction with the service.Design/methodology/approach – Questionnaires were administered to 198 participants, comprising 99 service provider‐customer dyads coming from public service organizations, that is government offices, welfare services, health services, and education, and private services, that is banks and communication companies. The dyads selected for the study were engaged in a “service relationship,” that is, the customer h.
Model predictive power stabilizer optimized by PSO

An electric power system (EPS) often exhibits low frequency electromechanical oscillations due to insufficient damping caused by adverse operating conditions. In this paper, a model predictive power stabilizer (MPPS) is proposed to improve the oscillations in a single machine infinite bus (SMIB) power system. This approach is part of a small signal stability analysis that uses equations in incremental form around an operating point. The MPPS provides the optimal control inputs and design parameters were optimized using particle swarm optimization (PSO). A conventional power system stabilizer (CPSS), with parameters also optimized with PSO, was used for comparison. A large number of dynamic system responses for different values of power and system parameters have been used to validate our proposals.
Role of Contracts in Agro-Industrial Coordination: A Look Beyond Markets

This essay departs from the question about the limited adoption of the contractual approach in the field of Agricultural Economics in Brazil. It discusses the relevance of the contractual approach to the theory of the firm, presents the evolution of the studies of coordination in food chains in Brazil and abroad, and concludes suggesting a research and educational agenda for applied Agricultural Economics.
Application of soft computing methods to detect fault in A.C motor

The paper investigates the effectiveness of Soft computing methods to detect the fault in A.C. Motor. In this paper Feed Forward Back Propagation (FFBP) and Radial Basis Function (RBF) Neural Network controller is used as soft computing method and Three Phase Induction motor is used as AC Motor. Both the neural network controller is used here as classifier to classify the healthy and unhealthy condition of the motor. Discrimination of the inner race and outer race bearing fault of the proposed motor is carried out using Park's Transformation with motor steady current signals. Both controllers' gives good results for the above purpose but The RBF neural networks shows very encouraging results for multi-class classification problems. which proves the effectiveness of the controller for setting up a base in incipient fault detection of Induction Motor.
Concurrent Alignment of Human Resource Management and Business Strategies

Main objective of the present survey is to study human resource management (HRM) and Business strategies alignment. This survey was conducted using the field-descriptive method. The historical study method was used to collect theoretical subjects and the field study method was applied to confirm or reject research hypotheses. Based on cluster-stratified sampling method, the statistical population of this research included all experts and managers at various levels in the Mapna Group. According to results of the present survey, there is a direct correlation between HRM and Business strategies.
Meta-analysis of published frequencies of the first decade of field-based mortality and seropositivity in avian species affected by West Nile virus in the United States

A meta-analysis approach was used to extract the frequency of avian seropositivity to West Nile Virus (WNV) (fS) and mortality from WNV (fM) from the literature published between the years 2001-2010. The indices, fS and fM, were used to represent states of resistance (seropositivity with no or limited mortality) and susceptibility in birds (detection of WNV with mortality), respectively. The indices fS and fM were calculated for each species across publications into different taxonomic strata, year, combined time intervals, and geographic location. The data were analyzed by logistic regression to assess the status of WNV infection amongst different avian taxonomic strata and infer changes of WNV infection status over time. Using level of peak viremia as a proxy for host competence among the avian species, the value of the phylogenetic signal was tested by
EFFECTIVE STRATEGIES FOR EXPANDING THE SYSTEM OF CARE APPROACH A Report on the Study of Strategies for Expanding Systems of Care

The views expressed herein do not necessarily reflect the official policies of the Department of Health and Human Services, nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. (2011). Effective strategies for expanding the system of care approach. A report on the study of strategies for expanding systems of care. Atlanta, GA: ICF Macro.
A Test Adaptation of the Modified Readiness for Inter-professional Learning Scale in Turkish

Background: There is a need for healthcare professionals to develop teamwork and collaboration skills before they graduate. Inter-professional education is a suitable modality for these learning outcomes and it will be effective if it begins early in the undergraduate curriculum. Objectives: “Inter-professional Collaboration for Patient Safety” has been taught as an elective course in Hacettepe University. This new educational modality requires measuring tools to determine the qualifications of the learners and support the learning process. This study aimed to adapt the readiness for inter-professional learning scale (RIPLS) for use in Turkey. Methods: The guideline developed by Sousa and Rojjanasrirat (2011) guided the adaptation processes. The students enrolled in the study from Child Development, Dentistry, Medicine, Nursing, Nutrition and Dietetics, Paramedic, Pharmacy, Physiotherapy and Rehabilitation programs. Four hundred and eighty-four students completed RIPLS questionnaires. Psychometric properties were analysed by confirmatory factor analysis. Results: The results were consistent with the original scale. When Sousa’s approach was followed: (i) improvements were needed for four items, (ii) the scale items were clear and understandable, (iii) the Turkish RIPLS presents good content validity, and (iv) the Turkish RIPLS has very good internal consistency (0.87, n=484). Conclusions: The Turkish RIPLS can be used as a valid and reliable measurement tool for evaluating the RIPL. Adaptation studies showed that the RIPLS was sensitive to cultural context. Researchers should be cautious on performing cross-cultural comparisons of subscale ‘roles and responsibilities’ because The Turkish RIPLS had the lowest value of reliability for this subscale, like the original and the other adapted scales.