Miracle-dz/UniFAR-FTUs huggingface dataset:
SAE TECHNICAL PAPER SERIES 2006-01-0961 Optimizing Vehicle Occupant Packaging

Occupant packaging practice relies on statistical models codified in SAE practices, such as the SAE J941 eyellipse, and virtual human figure models representing individual occupants. The current packaging approach provides good solutions when the problem is relatively unconstrained, but achieving good results when many constraints are active, such as restricted headroom and sightlines, requires a more rigorous approach. Modeling driver needs using continuous models that retain the residual variance associated with performance and preference allows use of optimization methodologies developed for robust design. Together, these models and methods facilitate the consideration of multiple factors simultaneously and tradeoff studies can be performed. A case study involving the layout of the interior of a passenger car is presented, focusing on simultaneous placement of the seat and steering wheel adjustment ranges. Tradeoffs between adjustability, driver accommodation, and exterior vision are explored under this paradigm. These results are contrasted with those obtained using boundary manikins.
Protection of silver nanoparticles using Eysenhardtia polystachya in peroxide-induced pancreatic β-Cell damage and their antidiabetic properties in zebrafish

Background The aim was to explore the efficacy of extract of Eysenhardtia polystachya-loaded silver nanoparticles (EP/AgNPs) on pancreatic β cells, INS-1 cells, and zebrafish as a valuable model for the study of diabetes mellitus. Materials and methods EP/AgNPs were synthesized using methanol/water bark extract of E. polystachya and characterized using various physicochemical techniques. Results Immersion of adult zebrafish in 111 mM glucose solution resulted in a sustained hyperglycemic, hyperlipidemic state, and serum insulin levels decreased. The synthesized EP/AgNPs showed an absorption peak at 413 nm on ultraviolet–visible spectroscopy, revealing the surface plasmon resonance of the nanoparticles. Transmission electron microscopy indicated that most of the particles were spherical, with a diameter of 10–12 nm, a polydispersity index of 0.197, and a zeta potential of −32.25 mV, suggesting high stability of the nanoparticles. EP/AgNPs promote pancreatic β-cell survival, insulin secretion, enhanced hyperglycemia, and hyperlipidemia in glucose-induced diabetic zebrafish. EP/AgNPs also showed protection of the pancreatic β-cell line INS-1 against hydrogen peroxide-induced oxidative injury. Conclusion The results indicate that EP/AgNPs have good antidiabetic activity and therefore could be used to prevent the development of diabetes.
Derivation of the short form of the Oral Health Impact Profile in Spanish (OHIP-EE-14).

BACKGROUND AND OBJECTIVE The Oral Health Impact Profile is the most frequently used and validated of the Oral Health Quality of Life instruments. Several short versions have been developed; and a validation of the OHIP-49 in Spanish has been published. The objective was to develop the short version of the Oral Health Impact Profile in Spanish (OHIP-EE-14). METHODS Cross-sectional study. One hundred and thirty-one persons aged ≥60 years attending a social centre for the elderly, residents of a nursing home and persons seeking dental care at a dental school in Mexico City were interviewed and examined. The validity of each of the 49 questions was evaluated, and, to construct the short version, 14 items were selected. The perceived need for dental treatment, number of teeth, presence of coronal caries, root caries, presence of dental plaque and utilisation of removable prosthesis were measured. Internal consistency, repeatability and discriminant validity were calculated. RESULTS The OHIP-EE-14 was reliable (Cronbach's-α = 0.918, ICC = 0.825). Significant associations were found between OHIP-EE-14 and the number of teeth and perceived need for dental treatment. CONCLUSIONS The OHIP-EE-14 is a reliable and valid instrument and can be used in subjects aged 60 years and over from Mexico City.
A single position loop control strategy for high-speed voice coil motor based on active disturbance rejection control

To improve the dynamic performance of voice coil motor, a single position loop control method based on active disturbance rejection control is proposed in this paper. The feedback law is sufficiently analyzed and well designed considering both sinusoidal input and step reference input. Moreover, stability analysis is conducted on the basis of a state-space model and Routh-Hurwitz criterion, which is proved to be stable and convergent under proper parameter arrangement. Further, simulation and experimental validation indicate that the proposed control strategy has faster step response and better tracking accuracy compared with traditional three-loop PI controller with only one eighth of settling time and less than half of the tracking error compared to PI controller.
Evaluation of a novel non-invasive preimplantation genetic screening approach

Objective To assess whether embryonic DNA isolated from blastocyst culture conditioned medium (BCCM) combined with blastocoel fluid (BF) could be used for blastocyst stage non-invasive preimplantation genetic testing for chromosomal aneuploidy (non-invasive preimplantation genetic screening, NIPGS). Patients 47 embryos from 35 patients undergoing IVF. Interventions DNA analysis of combined BCCM plus BF in comparison with trophectoderm (TE) biopsy and/or whole blastocyst (WB)using next generation sequencing (NGS). Results Embryonic DNA was successfully amplified in 47/47 NIPGS samples (28 frozen-thawed and 19 fresh culture samples) ranging from 6.3 to 44.0 ng/μl. For frozen-thawed embryos, the concordance rate for whole chromosome copy number per sample was equivalent between NIPGS vs. TE biopsy, NIPGS vs. WB and TE vs. WB samples taken from the same embryo was 87.5%; 96.4% and 91.7% respectively (P>0.05), and the rate of concordance per single chromosome was 99.3%, 99.7% and 99.7%, respectively (P>0.05). In fresh cases (Day 4 to Day 5/6 culture), the concordance rate for whole chromosome copy number per sample between NIPGS vs. TE samples taken from the same embryo was 100%, and the rate of concordance per single chromosome was 98.2% (P>0.05). Conclusions A combination of BCCM and BF contains sufficient embryonic DNA for whole genome amplification and accurate aneuploidy screening. Our findings suggest that aneuploidy screening using BCCM combined with BF could potentially serve as a novel NIPGS approach for use in human IVF.
Genetic Divergence of an Avian Endemic on the Californian Channel Islands

The Californian Channel Islands are near–shore islands with high levels of endemism, but extensive habitat loss has contributed to the decline or extinction of several endemic taxa. A key parameter for understanding patterns of endemism and demography in island populations is the magnitude of inter–island dispersal. This paper estimates the extent of migration and genetic differentiation in three extant and two extinct populations of Channel Island song sparrows (Melospiza melodia graminea). Inter–island differentiation was substantial (G''ST: 0.14–0.37), with San Miguel Island having the highest genetic divergence and lowest migration rates. Santa Rosa and Santa Cruz Island populations were less diverged with higher migration rates. Genetic signals of past population declines were detected in all of the extant populations. The Channel Island populations were significantly diverged from mainland populations of M. m. heermanni (G''ST: 0.30–0.64). Ten mtDNA haplotypes were recovered across the extant and extinct Channel Island population samples. Two of the ten haplotypes were shared between the Northern and Southern Channel Islands, with one of these haplotypes being detected on the Californian mainland. Our results suggest that there is little contemporary migration between islands, consistent with early explanations of avian biogeography in the Channel Islands, and that song sparrow populations on the northern Channel Islands are demographically independent.
Reporting Qualitative Research: Standards, Challenges, and Implications for Health Design

Objective: This Methods column describes the existing reporting standards for qualitative research, their application to health design research, and the challenges to implementation. Intended for both researchers and practitioners, this article provides multiple perspectives on both reporting and evaluating high-quality qualitative research. Background: Two popular reporting standards exist for reporting qualitative research—the Consolidated Criteria for Reporting Qualitative Research (COREQ) and the Standards for Reporting Qualitative Research (SRQR). Though compiled using similar procedures, they differ in their criteria and the methods to which they apply. Creating and applying reporting criteria is inherently difficult due to the undefined and fluctuating nature of qualitative research when compared to quantitative studies. Conclusions: Qualitative research is expansive and occasionally controversial, spanning many different methods of inquiry and epistemological approaches. A “one-size-fits-all” standard for reporting qualitative research can be restrictive, but COREQ and SRQR both serve as valuable tools for developing responsible qualitative research proposals, effectively communicating research decisions, and evaluating submissions. Ultimately, tailoring a set of standards specific to health design research and its frequently used methods would ensure quality research and aid reviewers in their evaluations.
Expanding NEURON's Repertoire of Mechanisms with NMODL

Neuronal function involves the interaction of electrical and chemical signals that are distributed in time and space. The mechanisms that generate these signals and regulate their interactions are marked by a rich diversity of properties that precludes a one size fits all approach to modeling. This article presents a summary of how the model description language NMODL enables the neuronal simulation environment NEURON to accommodate these differences.
Towards Generating Multiple-Choice Tests for Evaluating Comprehension of Arbitrary English Texts

We develop a method for generating multiple-choice test for evaluating comprehension of an arbitrary English text and its answer to support more extensive reading in English. Our test consists of one sentence (a correct optional sentence) that is consistent with the selected English text and several sentences (distractor optional sentences) that are inconsistent with this text. Learners select one sentence consistent with the text from multiple optional sentences on reading the text. In our proposed method, the system extracts several important sentences from the text, and replaces at least one word in each of these sentences with its synonym (if possible). One of these sentences is then selected as the correct response, while further changes to the polarities or nouns in the remaining sentences are carried out to generate distractor sentences for the multiple-choice test. Our method has potential to improve the learning effect associated with extensive reading.
Dipeptidyl peptidase‐4 inhibition prevents cell death via extrinsic and intrinsic apoptotic pathways in rat pancreas with insulin resistance

The study aims to evaluate the effect of saxagliptin, a specific inhibitor of dipeptidyl peptidase‐4 enzymes, on body weight gain, lipid profiles, and cell death through apoptosis in rats with insulin resistance (IR). Male adult Sprague‐Dawley rats (n = 32) were divided into 4 groups: control (Ctrl), IR, saxagliptin control, and IR treated with saxagliptin(IR + S). Insulin resistance was induced by 10% fructose in the drinking water for 8 weeks. Saxagliptin (10 mg/kg/day) was administrated by oral gavage for 2 weeks. Biochemical parameters were measured spectrophotometrically. Peptides were determined by the streptavidin‐biotin‐peroxidase method. Although the amount of food and liquid consumed are inversely proportional, the calories received are almost equal between both Ctrl and IR groups, as well as IR and IR + S groups. Increased homeostasis model assessment for insulin resistance, HOMA‐β, triglycerides, and very low‐density lipoprotein in the IR group were comparatively decreased by saxagliptin administration. The area percentage of caspase‐3 and apoptotic peptidase activating factor‐1 immunopositive cells in the IR + S group decreased compared with the IR group. Similarly, the percentages of caspase‐8 and ‐9 immunopositive cells in the IR group were higher than the IR + S group. It was observed that the percentage of poly (ADP‐ribose) polymerase‐1 immunopositive cells was increased in the IR + S group compared with the IR group. Thus, saxagliptin may prevent IR‐induced apoptotic cell death and regulate impaired homeostasis model assessment for insulin resistance and serum lipid levels.
2D phase‐sensitive inversion recovery imaging to measure in vivo spinal cord gray and white matter areas in clinically feasible acquisition times

To present and assess a procedure for measurement of spinal cord total cross‐sectional areas (TCA) and gray matter (GM) areas based on phase‐sensitive inversion recovery imaging (PSIR). In vivo assessment of spinal cord GM and white matter (WM) could become pivotal to study various neurological diseases, but it is challenging because of insufficient GM/WM contrast provided by conventional magnetic resonance imaging (MRI).
Optical trapping and binding in air: Imaging and spectroscopic analysis

We report on an experimental study of direct and spectroscopic imaging of optically trapped Mie droplets in air. The scattering of the trapping beams gives glare points at the droplets' azimuths. Spectroscopic measurements involving polarized light are performed to precisely determine both the droplet sizes and refraction index using Mie scattering theory. Experimental pictures are compared to rigorous numerical simulations. We also include some results on imaging of whispering gallery resonances and conclude with a brief discussion on the possibility of efficiently exciting whispering gallery resonances via radiative coupling.
Congruent representation of visual and acoustic space in the superior colliculus of the echolocating bat Phyllostomus discolor

The midbrain superior colliculus (SC) commonly features a retinotopic representation of visual space in its superficial layers, which is congruent with maps formed by multisensory neurons and motor neurons in its deep layers. Information flow between layers is suggested to enable the SC to mediate goal‐directed orienting movements. While most mammals strongly rely on vision for orienting, some species such as echolocating bats have developed alternative strategies, which raises the question how sensory maps are organized in these animals. We probed the visual system of the echolocating bat Phyllostomus discolor and found that binocular high acuity vision is frontally oriented and thus aligned with the biosonar system, whereas monocular visual fields cover a large area of peripheral space. For the first time in echolocating bats, we could show that in contrast with other mammals, visual processing is restricted to the superficial layers of the SC. The topographic representation of visual space, however, followed the general mammalian pattern. In addition, we found a clear topographic representation of sound azimuth in the deeper collicular layers, which was congruent with the superficial visual space map and with a previously documented map of orienting movements. Especially for bats navigating at high speed in densely structured environments, it is vitally important to transfer and coordinate spatial information between sensors and motor systems. Here, we demonstrate first evidence for the existence of congruent maps of sensory space in the bat SC that might serve to generate a unified representation of the environment to guide motor actions.
The prognostic effect of cardiac rehabilitation in the era of acute revascularisation and statin therapy: A systematic review and meta-analysis of randomized and non-randomized studies – The Cardiac Rehabilitation Outcome Study (CROS)

Background The prognostic effect of multi-component cardiac rehabilitation (CR) in the modern era of statins and acute revascularisation remains controversial. Focusing on actual clinical practice, the aim was to evaluate the effect of CR on total mortality and other clinical endpoints after an acute coronary event. Design Structured review and meta-analysis. Methods Randomised controlled trials (RCTs), retrospective controlled cohort studies (rCCSs) and prospective controlled cohort studies (pCCSs) evaluating patients after acute coronary syndrome (ACS), coronary artery bypass grafting (CABG) or mixed populations with coronary artery disease (CAD) were included, provided the index event was in 1995 or later. Results Out of n = 18,534 abstracts, 25 studies were identified for final evaluation (RCT: n = 1; pCCS: n = 7; rCCS: n = 17), including n = 219,702 patients (after ACS: n = 46,338; after CABG: n = 14,583; mixed populations: n = 158,781; mean follow-up: 40 months). Heterogeneity in design, biometrical assessment of results and potential confounders was evident. CCSs evaluating ACS patients showed a significantly reduced mortality for CR participants (pCCS: hazard ratio (HR) 0.37, 95% confidence interval (CI) 0.20–0.69; rCCS: HR 0.64, 95% CI 0.49–0.84; odds ratio 0.20, 95% CI 0.08–0.48), but the single RCT fulfilling Cardiac Rehabilitation Outcome Study (CROS) inclusion criteria showed neutral results. CR participation was also associated with reduced mortality after CABG (rCCS: HR 0.62, 95% CI 0.54–0.70) and in mixed CAD populations. Conclusions CR participation after ACS and CABG is associated with reduced mortality even in the modern era of CAD treatment. However, the heterogeneity of study designs and CR programmes highlights the need for defining internationally accepted standards in CR delivery and scientific evaluation.
Chemical–gene relation extraction using recursive neural network

Abstract In this article, we describe our system for the CHEMPROT task of the BioCreative VI challenge. Although considerable research on the named entity recognition of genes and drugs has been conducted, there is limited research on extracting relationships between them. Extracting relations between chemical compounds and genes from the literature is an important element in pharmacological and clinical research. The CHEMPROT task of BioCreative VI aims to promote the development of text mining systems that can be used to automatically extract relationships between chemical compounds and genes. We tested three recursive neural network approaches to improve the performance of relation extraction. In the BioCreative VI challenge, we developed a tree-Long Short-Term Memory networks (tree-LSTM) model with several additional features including a position feature and a subtree containment feature, and we also applied an ensemble method. After the challenge, we applied additional pre-processing steps to the tree-LSTM model, and we tested the performance of another recursive neural network model called Stack-augmented Parser Interpreter Neural Network (SPINN). Our tree-LSTM model achieved an F-score of 58.53% in the BioCreative VI challenge. Our tree-LSTM model with additional pre-processing and the SPINN model obtained F-scores of 63.7 and 64.1%, respectively. Database URL: https://github.com/arwhirang/recursive_chemprot
Aalto Aparat – A freely available tool for glottal inverse filtering and voice source parameterization

A software tool, Aalto Aparat, is introduced for glottal inverse filtering analysis of human voice production. The tool enables using two inverse filtering methods (Iterative adaptive inverse filtering, Quasi closed phase analysis) to estimate the glottal flow from speech. The inverse filtering analysis can be conducted using a graphical interface either automatically or in a semiautomatic manner by allowing the user to select the best glottal flow estimate from a group of candidates. The resulting glottal flow is parameterized with a multitude of know parameterization methods. Aalto Aparat is easy to use and it calls for no programming skills by the user. This new software tool can be downloaded as a stand-alone package free of charge to be run on two operating systems (Windows and Mac OS).
Safety of Human Papillomavirus 9-Valent Vaccine: A Meta-Analysis of Randomized Trials

Vaccination against human papillomavirus (HPV) has been progressively implemented in most developed countries for approximately 10 years. In order to increase the protection of the vaccines, a 9-valent vaccine (HPV9) was developed, which provides protection against nine types of the virus. Studies evaluating its safety are rare. Thus, we performed a meta-analysis of three clinical trials assessing adverse effects on women randomly vaccinated with HPV9 or tetravalent vaccine (HPV4), with the objective of analyzing whether the HPV9 is as safe as HPV4. An electronic data search was performed through the PubMed, Embase, Scopus, Web of Science, and SciELO databases. The studies selected 27,465 women who received one of the two vaccines. Pain (OR 1.72; 95% CI 1.62–1.82) and erythema (OR 1.29; 95% CI 1.21–1.36) occurred significantly more in the HPV9 group. However, there was no significant difference between the groups for the following adverse effects: headache (OR 1.07; 95% CI 0.99–1.15), dizziness (OR 1.09; 95% CI 0.93–1.27), and fatigue (OR 1.09; 95% CI 0.91–1.30), and the occurrence of serious events related to vaccination was similarly rare among those vaccinated. Therefore, our findings demonstrate that HPV9 in female patients is as safe as the tetravalent vaccine.
An Interdisciplinary Intervention for Fear of Falling: Lessons Learned from Two Case Studies

ABSTRACT This article describes two case studies using an interdisciplinary intervention for homebound older adults who experience fear of falling, resulting in debility and isolation. The patients discussed received separate home visits from a physical therapist (two and four visits) and psychologist (six and eight visits) and intervention components included an initial assessment of physical ability, prescription of home exercise program, exposure therapy, and cognitive restructuring. Both patients reported satisfaction with the fear of falling intervention and showed improved ability to walk, both in distance and in requiring less assistance. These findings suggest significant positive treatment effects can be achieved through interdisciplinary exposure-based interventions aimed at reducing unrealistic fear of falling and associated avoidance behaviors. Similar interventions should be considered for more systematic evaluation of effects and mechanisms of change as well as inclusion in interdisciplinary treatment planning.
Practical Method for Detection and Identification of Candida, Aspergillus, and Scedosporium spp. by Use of Rolling-Circle Amplification

ABSTRACT A sensitive rolling-circle amplification (RCA)-based method utilizing species-specific padlock probes targeted to the internal transcribed spacer 2 region of the fungal ribosomal DNA gene complex was developed. The assay was rapid (2 hours) and specific. Of 28 fungal isolates (16 of Candida, six of Aspergillus, and six of Scedosporium spp.), all were all identified correctly.