Miracle-dz/UniFAR-FTUs huggingface dataset:
Empirically Based Assessment of Child and Adolescent Psychopathology: Practical Applications

Principles, Methods, and Goals of Empirically Based Assessment Strategies for Using Empirically Based Assessment The Nature and Correlates of Empirically Based Syndromes Applying Empirically Based Assessment Case Illustrations for Elementary School Ages Case Illustrations for Adolescents Illustrations of Special Assessment Needs Essential Features of Empirically Based Assessment
An Efficient Sleep Mode Management Scheme in IEEE 802.16e Networks

In IEEE 802.16e networks, the mobility of mobile stations (MSs) induces that energy saving becomes an important issue for the battery-powered MSs to extend their operational lifetime. Based on the characteristics of power saving class (PSC) types and data delivery service types defined in IEEE 802.16e standard, we propose an efficient sleep mode management scheme to save energy. Using the quality of service (QoS) parameters associated with transport connections, we not only design the downlink and uplink PSC parameters, but also introduce the PSC anti-expansion mechanism. The analyses and simulation results demonstrate that the proposed scheme can minimize the energy consumption of MSs under the condition that the QoS requirements of each connection are guaranteed.
Theobrominium perchlorate dibenzo-18-crown-6 3.25-hydrate

The co-crystal, C7H9N4O2 +·ClO4 −·C20H24O6·3.25H2O, consists of theobrominium (3,7-dimethyl-2,6-dioxo-1H-purin-9-ium) cations, perchlorate anions and dibenzo-18-crown-6 and water molecules. The crown ether is in a bent conformation, in which the planes of the aromatic rings subtend an angle of 63.7 (1)°. Intermolecular O—H⋯O hydrogen bonding between the water molecules and the O atoms of the cyclic ether delimit an empty space reminiscent of a hollow cage. The water molecules are additionally linked to the cations by N—H⋯O hydrogen bonding. One of the positions of the water molecules is occupied only fractionally (25%) and is located outside this framework.
Phenylalanine containing hydrophobic nanospheres for antibody purification

In this study, novel hydrophobic nanospheres with an average size of 158 nm utilizing N‐methacryloyl‐(L)‐phenylalanine methyl ester (MAPA) as a hydrophobic monomer were produced by surfactant free emulsion polymerization of 2‐hydroxyethyl methacrylate (HEMA) and MAPA conducted in an aqueous dispersion medium. MAPA was synthesized using methacryloyl chloride and L‐phenylalanine methyl ester. Specific surface area of the nonporous nanospheres was found to be 1874 m2/g. Poly(HEMA–MAPA) nanospheres were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Average particle size, size distribution, and surface charge measurements were also performed. Elemental analysis of MAPA for nitrogen was estimated as 0.42 mmol/g polymer. Then, poly(HEMA–MAPA) nanospheres were used in the adsorption of immunoglobulin G (IgG) in batch system. Higher adsorption values (780 mg/g) were obtained when the poly (HEMA–MAPA) nanospheres were used from both aqueous solutions and human plasma. The adsorption phenomena appeared to follow a typical Langmuir isotherm. It was observed that IgG could be repeatedly adsorbed and desorbed without significant loss in adsorption amount. These findings show considerable promise for this material as a hydrophobic support in industrial processes.
Guidelines for Establishing a Donor Human Milk Depot

Human milk is the preferred choice for infant feeding. When a sick or premature infant’s own mother’s milk is unavailable, donor human milk is becoming more widely used. Many potential milk donors do not live within close proximity to the 10 North American not-for-profit milk banks. Transporting milk via commercial carriers can be inconvenient and costly for recipient banks. A network of donor human milk depots is one practical way to increase the quantity of available donor human milk. This article provides guidelines and practical suggestions for establishing a donor human milk depot.
Validation of an established prognostic score after re-irradiation of recurrent glioma

Abstract Background: Re-irradiation (Re-RT) is offered widely in clinical routine, and has been established as a key element in the treatment of recurrent gliomas. At our center, generally re-resection is performed widely by an experienced neurosurgical team. Thus, Re-RT mostly offered to patients with macroscopic residuals or irresectable lesions, is applied later compared to other centers. Therefore, we sought to validate the Combs Prognostic Score developed in 2012 using our independent patient cohort. Patients and methods: We included 199 patients treated from 2002 until April 2016 for recurrent glioma at the Department of Radiation Oncology at the Klinikum Rechts der Isar, Munich. Different concepts of Re-RT were applied. Results: Median follow-up after Re-RT was 2.5 months. Median overall survival (OS) after Re-RT was 7.9 months for WHO IV gliomas, 11.3 months for WHO III gliomas, and 13.6 months for low-grade gliomas (WHO I/II). Univariate analyses confirmed the prognostic factors primary histology (p = 0.001), age (p = 0.002), and time between primary radiotherapy and Re-RT (p < 0.001). We also tested Karnofsky Performance Score (KPS), gender, and neurological symptoms before Re-RT as well as planning target volume and found only KPS also significant at p < 0.001. Comparing the prognostic score groups, the outcome was highly statistically significant at p < 0.001. Conclusion: In our analysis, we validated the Combs Prognostic Score. Validation in this independent large patient cohort confirms the significance of the score for glioma recurrences. Thus, the role of the Combs Prognostic Score might be an essential component of future clinical decision making and patient stratification.
Perceptions of Instrumental Music Teachers regarding the Development of Effective Rehearsal Techniques

The purpose of this study was to examine the perceptions of two third-year instrumental music teachers concerning their early career development of successful rehearsal techniques. Participants were observed over the course of three days in their classroom environment and posed questions based upon the rehearsal techniques they incorporated into their instruction. Triangulation was achieved through interviews of both participants regarding the same subject matter, as well as interviews with the instrumental music teachers that work alongside the participants on a daily basis (in-house colleagues). Both participants credited their in-house colleague and reflection-on-action as the two most influential elements found within their teaching setting. Through those influences, the participants cited their development in regard to planning, pacing, repertoire selection, and classroom management. Regarding influential factors pursued outside of their teaching responsibilities, both participants identified their community colleagues as well as the act of recording of their own rehearsals as most beneficial to their development. The results of this study reinforce the need for early teaching experiences in combination with the acquisition of teaching techniques in pre-service music education methods courses. Experiences in pre-service instruction that facilitate reflection-on-action may also benefit early career music educators in their rehearsal technique development.
Multi-Object Geodesic Active Contours ( MOGAC ) : A Parallel Sparse-Field Algorithm for Image Segmentation

An important task for computer vision systems is to segment adjacent structures in images without producing gaps or overlaps. Multi-object Level Set Methods (MLSM) perform this task with the benefit of sub-pixel accuracy. However, current implementations of MLSM are not as computationally or memory efficient as their region growing and graph cut counterparts which lack sub-pixel accuracy. To address this performance gap, we present a novel parallel implementation of MLSM that leverages the sparse properties of the segmentation algorithm to minimize its memory footprint for multiple objects. The new method, Multi-Object Geodesic Active Contours (MOGAC), can represent N objects with just two functions: a label image and unsigned distance field. The time complexity of the algorithm is shown to be O((M^d)/P) for M^d pixels and P processing units in dimension d={2,3}, independent of the number of objects. Results are presented for 2D and 3D image segmentation problems.
Evaluation of EBV transformation of human memory B-cells isolated by FACS and MACS techniques

Abstract Several studies have been performed to develop effective neutralizing monoclonal antibodies. The Epstein–Barr virus (EBV) can efficiently immortalize B-cells to establish lymphoblastoid cell lines (LCL) and so it has been used extensively for transformation of B-cells to produce and secrete immunoglobulin. The present study addressed the effect of TLR7/8 agonist (R848), feeder cells layer and ﬂuorescence-activated cell sorting (FACS) and magnetic-activated cell sorting (MACS) cell separation methods on the transformation efficiency of antibody-producing memory B-cells. For these studies, the antigen used for analyses of antibody formation was the tetanus neurotoxin (TeNT) derived from Clostridium tetani. The results here showed that employing an HFFF.PI6 feeder cell layer, R848 agonist and FACS-mediated purification of memory B-cells led to increased transformation efficiency. Altogether, the effects of the R848 and the feeder cells provided an efficient method for EBV transformation of human B-cells. Moreover, there was an advantage in using FACS sorting of B-cells over the MACS method in the context of EBV transformation and immortalization of precursors of antigen-specific B-cells.
Control of the Bacillus subtilis Antiterminator Protein GlcT by Phosphorylation

Bacillus subtilis transports glucose by the phosphotransferase system (PTS). The genes for this system are encoded in the ptsGHI operon, which is induced by glucose and depends on a termination/antitermination mechanism involving a riboswitch and the RNA-binding antitermination protein GlcT. In the absence of glucose, GlcT is inactive, and a terminator is formed in the leader region of the ptsG mRNA. If glucose is present, GlcT can bind to its RNA target and prevent transcription termination. The GlcT protein is composed of three domains, an N-terminal RNA binding domain and two PTS regulation domains, PTS regulation domain (PRD) I and PRD-II. In this work, we demonstrate that GlcT can be phosphorylated by two PTS proteins, HPr and the glucose-specific enzyme II (EIIGlc). HPr-dependent phosphorylation occurs on PRD-II and has a slight stimulatory effect on GlcT activity. In contrast, EIIGlc phosphorylates the PRD-I of GlcT, and this phosphorylation inactivates GlcT. This latter phosphorylation event links the availability of glucose to the expression of the ptsGHI operon via the phosphorylation state of EIIGlc and GlcT. This is the first in vitro demonstration of a direct phosphorylation of an antiterminator of the BglG family by the corresponding PTS permease.
Managing Laser Power in Silicon-Photonic NoC Through Cache and NoC Reconfiguration

In manycore systems, the silicon-photonic link technology is projected to replace electrical link technology for global communication in network-on-chip (NoC) as it can provide as much as an order of magnitude higher bandwidth density and lower data-dependent power. However, a large amount of fixed power is dissipated in the laser sources required to drive these silicon-photonic links, which negates any bandwidth density advantages. This large laser power dissipation depends on the number of on-chip silicon-photonic links, the bandwidth of each link, and the photonic losses along each link. In this paper, we propose to reduce the laser power dissipation at runtime by dynamically activating/deactivating L2 cache banks and switching ON/OFF the corresponding silicon-photonic links in the NoC. This method effectively throttles the total on-chip NoC bandwidth at runtime according to the memory access features of the applications running on the manycore system. Full-system simulation utilizing Princeton application repository for shared-memory computers and Stanford parallel applications for shared-memory-2 parallel benchmarks reveal that our proposed technique achieves on an average 23.8% (peak value 74.3%) savings in laser power, and 9.2% (peak value 26.9%) lower energy-delay product for the whole system at the cost of 0.65% loss (peak value 2.6%) in instructions per cycle on average when compared to the cases where all L2 cache banks are always active.
The European puzzle. The political structuring of cultural identities at a time of transition

"The book claims that its primary aim is to reconcile unity and diversity by offering an interdisciplinary approach to questions of European identity/identities. Despite the variety of approaches and themes develA--oped, the book successfully bridges this interdisciplinarity and provides a coherent flow of analysis of European identity which, as the title best illustrates, still remains a puzzle to be explored. The book therefore highlights the complexity of constructing European identity from political and cultural means.Overall it intellectually alerts the reader to some of the most significant challenges facing European identity and will be very useful to experts in the field. " * Political Studies Review The twin concepts of "Culture" and "Identity" are inescapable in any discussion of European Integration and yet over the last ten years their meaning has become increasingly contested. By combining an anthropological and political perspective, the authors challenge the traditional boundaries within the issue of the construction of Europe. In the first part, historians and anthropologists from various national traditions discuss the process of the construction of Europe and its implications for cultural identities. The second section examines a number of topics at the core of the process of Europeanization and presents up-to-date information on each of these issues: political parties, regions, football, cities, the Euro, ethnicity, heritage and European cinema. Emphasis is be placed on the political structuring of cultural identities by contrasting top-down and bottom-up processes that define the tensions between the unity and diversity of the European Community. Marion Demossier is a senior lecturer in French and Anthropology at the University of Bath. She is the co-ordinator of a postgraduate Euromasters and Trans-Atlantic Masters course on 'Culture and identity in Europe' which has provided the material for this book. She has published extensively on the Anthropology of rural France and has recently edited a book on Recollections of France: Memories, Identities and Heritage (Berghahn, 2001). Her first monograph Hommes et Vins, une anthropologie du vignoble bourguignon was published in 1999 (editions universitaires de Dijon) and won a prize. She is currently preparing a monograph on Wine Culture and Consumption in France.
A New Proof of The Rhodes Type II Conjecture

For a given finite monoid M we explicitly construct a finite group G and a relational morphism τ:M→G such that only elements of the type II construct Mc relate to 1 under τ. This provides an elementary and constructive proof of the type II conjecture of John Rhodes. The underlying idea is also used to modify the proof of Ash's celebrated theorem on inevitable graphs. For any finite monoid M and any finite graph Γ a finite group G is constructed which "spoils" all labelings of Γ over M which are not inevitable.
Making Boys at Home in School? Theorising and Researching Literacy (Dis)connections

The relationship between home and school is often raised in public discussion about boys' education as an aspect of boys' overall lower achievement in school, and particularly in literacy, relative to girls. A critical review of two influential Australian and one UK government commissioned reports into boys' education sets the scene for our analysis in this paper. Analysing these reports, we demonstrate that their conclusions are drawn on the basis of minimal research engagement with students' out of school lives, relying instead on extrapolation from boys' orientations to school activities. We then examine conceptual resources developed by researchers taking a socio-cultural lens to relationships between students' in- and out- of school lives. We describe how we have drawn on these resources in designing and implementing a research project in collaboration with teachers in six schools in South Australia In this paper, we report how, given the constraints of a mostly school-based project, we nevertheless were able to generate significant knowledge about students' encounters with literacy practices outside the formal classroom. What we learned as a result of our analysis of multiple data sets raises questions about the models which construct conflicting relationships between in and out of school learning, and how these models map onto gender. At the same time, we show how resourcing teachers to generate knowledge about boys' out-of-school literacies produced some pedagogical changes which benefitted the 'boys of concern' and all students.
Presynaptic dopaminergic dysfunction in schizophrenia: a positron emission tomographic [18F]fluorodopa study.

CONTEXT The dopamine overactivity hypothesis of schizophrenia remains one of the most influential theories of the pathophysiology of the illness. Radiotracer brain imaging studies are now directly testing aspects of the overactivity hypothesis. OBJECTIVE To assess presynaptic dopaminergic function in a large cohort of patients with schizophrenia by means of [18F]fluorodopa uptake and a high-sensitivity 3-dimensional positron emission tomograph. We predicted elevations in striatal [18F]fluorodopa uptake and reductions in prefrontal cortical [18F]fluorodopa uptake in patients with schizophrenia. DESIGN Case-control study. SETTING Research institute investigation recruiting hospital outpatients. PATIENTS Sixteen male medicated hospital outpatients with a DSM-IV diagnosis of schizophrenia (mean age, 38 years) and 12 age-matched male volunteers free of psychiatric and neurologic illness. INTERVENTION [18F]fluorodopa positron emission tomographic scanning. MAIN OUTDOME MEASURE: [18F]fluorodopa uptake constant Ki measured with statistical parametric mapping and region-of-interest analyses. RESULTS Statistical parametric mapping (P<.05 corrected) and region-of-interest analyses (P<.01) showed increased [18F]fluorodopa uptake, confined primarily to the ventral striatum in patients with schizophrenia. No reductions in prefrontal cortical [18F]fluorodopa uptake Ki were seen in the statistical parametric mapping and region-of-interest analyses, although dorsal anterior cingulate [18F]fluorodopa Ki correlated with performance on the Stroop Color-Word Test in both groups. CONCLUSIONS As in studies in unmedicated patients, presynaptic striatal dopamine dysfunction is present in medicated schizophrenic patients, adding further in vivo support for dopamine overactivity in the illness.
Teaching Clinical Pharmacology Using Team‐Based Learning: A Comparison Between Third‐ and Fourth‐Year Medical Students

The purpose of this study was to formulate evidence‐based recommendations on whether to deliver the team‐based learning (TBL)‐designed clinical pharmacology course at the American University of Beirut Faculty of Medicine (AUBFM) during the third year instead of the fourth and final year of the medical curriculum. Between June 2010 and May 2011, AUBFM offered the course to both classes simultaneously to compare their performance. The findings of this endeavor supported the introduction of the course during the third year, first because fourth‐year students did not outperform third‐year students despite having the advantage of an additional year of clinical experience, and second, third‐year teams seemed more likely to develop into better functioning teams. The findings also suggested that simultaneous delivery of TBL sessions to both third‐ and fourth‐year teams was less favorably recommended because of the varying learning pace of both student groups.
Analysis of Digital Circuit Dynamic Behavior With Timed Ternary Decision Diagrams for Better-Than-Worst-Case Design

Modern logic optimization tools tend to optimize circuits in a balanced way so that all primary outputs (POs) have the similar delay close to the cycle time. However, in reality, certain POs will be exercised more frequently than the rest. Among the critical POs, some may be stabilized very quickly by input vectors, even if their topological delays from primary inputs are very long. Knowing the dynamic behavior of a circuit can help optimize the most commonly activated paths and help engineers understand how resilient a PO is against dynamic environmental variations such as voltage fluctuations. In this paper, we describe a tool to analyze the dynamic behavior of a digital circuit utilizing probabilistic information. The techniques exploit the use of timed ternary decision diagrams (tTDD) to encode stabilization conditions for POs. To compute probabilities based on a tTDD, we propose false assignment pruning and random variable compaction to preserve probability calculation accuracy. To deal with the scalability issue, this paper proposes a new circuit partitioning heuristic to reduce the inaccuracy introduced by partitioning. Compared to the timed simulation results, on average our tool has a mean absolute error of 1.7% and a root mean square error of 3.9% for MCNC benchmarks and a mean absolute error of 2.2% and a root mean square error of 4.8% for ISCAS benchmarks. Compared to a state-of-the-art dynamic behavior analysis tool, our tool is 15&times; faster on average for MCNC benchmarks and 65× faster on average for ISCAS benchmarks, and can also handle circuits that the previous tool cannot. This dynamic behavior analyzer would enable fast and effective circuit optimizations for better-than-worst-case design.
New Options for Rapid Typing of Salmonella enterica Serovars for Outbreak Investigation

A number of different serovars of Salmonella enterica are often implicated in human nontyphoidal outbreaks. Globally, serovars Typhimurium and Enteritidis are often the causative agent of such outbreaks, but other serovars can also be significant (Table 1). Some serovars such as Infantis and Virchow are routinely linked to outbreaks of gastroenteritis. The consumption of raw food products or poor food handling practices and/or storage procedures is often a catalyst for such outbreaks (Behravesh et al., 2010).