Miracle-dz/UniFAR-FTUs huggingface dataset:
New Crossover Operator for the Single Machine Scheduling Problem with Sequence-dependent Setup Times

An ergonomic musician's pick or pick holder for use with string instruments, such as a guitar, mandolin, bass guitar, or ukelele, has a curved finger grip portion on one side adapted to form a finger cradle for either the thumb or index finger of a user and has a flat generally planar area on another side against which the other fingers of a user may be pressed to allow the user to securely and comfortably grasp the pick for playing. The grip portion positively locates the fingers in a generally predetermined angular relationship to the string engaging pick tip. Different individual picks of the invention may have different angular relationships. The pick functions in the same way to bring the same advantages of the invention to any conventional and some non-standard or custom picks. Holder provides the added advantage that various picks may be used and the angular relationship may be more easily varied through various arrangements for attaching the pick to the holder. The simplicity of construction allows use of various materials in various thicknesses, sizes, and hardnesses, and materials to satisfy a wide range of playing conditions and preferences. The pick and holder have a folded configuration which is efficiently manufactured and allows convenient storage on the instrument strap or stings. The ergonomic grip design allows a more relaxed, and low pressure grip which is less likely to cause physical problems such as carpal tunnel syndrome and arm and back pain.
Galactic cold cores - III. General cloud properties

Context. In the project galactic cold cores we are carrying out Herschel photometric observations of cold regions of the interstellar clouds as previously identified with the Planck satellite. The aim of the project is to derive the physical properties of the population of cold clumps and to study its connection to ongoing and future star formation. Aims. We examine the cloud structure around the Planck detections in 71 fields observed with the Herschel SPIRE instrument by the summer of 2011. We wish to determine the general physical characteristics of the fields and to examine the morphology of the clouds where the cold high column density clumps are found. Methods. Using the Herschel SPIRE data, we derive colour temperature and column density maps of the fields. Together with ancillary data, we examine the infrared spectral energy distributions of the main clumps. The clouds are categorised according to their large scale morphology. With the help of recently released WISE satellite data, we look for signs of enhanced mid-infrared scattering (”coreshine”), an indication of growth of the dust grains, and have a first look at the star formation activity associated with the cold clumps. Results. The mapped clouds have distances ranging from similar to 100 pc to several kiloparsecs and cover a range of sizes and masses from cores of less than 10 M-circle dot to clouds with masses in excess of 10 000 M-circle dot. Most fields contain some filamentary structures and in about half of the cases a filament or a few filaments dominate the morphology. In one case out of ten, the clouds show a cometary shape or have sharp boundaries indicative of compression by an external force. The width of the filaments is typically similar to 0.2-0.3 pc. However, there is significant variation from 0.1 pc to 1 pc and the estimates are sensitive to the methods used and the very definition of a filament. Enhanced mid-infrared scattering, coreshine, was detected in four clouds with six additional tentative detections. The cloud LDN183 is included in our sample and remains the best example of this phenomenon. About half of the fields are associated with active star formation as indicated by the presence of mid-infrared point sources. The mid-infrared sources often coincide with structures whose sub-millimetre spectra are still dominated by the cold dust.
A Randomized Control Intervention Investigating the Effects of Acute Exercise on Emotional Regulation.

OBJECTIVES Exercise may help to cope with hectic or demanding events after a stressful situation occurs. Limited research has evaluated whether exercise, prior to a stressor, helps to facilitate subsequent emotional regulation. This pilot study addresses this novel paradigm. We employed a randomized controlled trial evaluating the effects of acute exercise on emotional regulation. METHODS Participants were randomly assigned to stretch (control group, N = 10), walk (N = 9), or jog (N = 8) for 15-minutes, after which they were exposed to a film clip intended to elicit a negative emotional response. Participants' emotions were monitored before and during exercise, as well as after the film clip. Emotional responses were evaluated using the Exercise Induced Feeling Inventory and Affective Circumplex Scale. RESULTS A group x time splitplot interaction effect was significant for anger (p = .046) and anxiousness (p = .038). Follow-up analyses showed that only the stretching group (p = .048) had a significantly increased anger score from baseline to post-film clip, suggesting a protective emotional effect from walking and jogging. CONCLUSIONS Exercise was effective in regulating anger and anxiousness after a stressful event. These findings provide evidence for potential preventive effects of exercise in facilitating emotional regulation.
Navigating the Social Governance Gap: An Exploration of Rio Tinto’s Administration of Citizenship Rights

When business organisations become involved in contributing to and resolving social issues, they enter areas traditionally seen as the purview of governments. In doing so, they begin to take on the expectations and responsibilities of government; they become politicised. This politicisation is a product of business’s success and power and appears largely unavoidable. Adopting Matten & Crane’s (2005a) extended view of corporate citizenship, business organisations’ responsibilities extend to the administration of citizens’ social, civil and political rights. We term these areas where business organisations take over the administration of citizenship rights as the social governance gap. Drawing upon the agenda of Margolis and Walsh (2003), we seek to enhance the understanding of how business navigates its responsibilities within the social governance gap, including its function as a significant actor influencing societal development and wellbeing. We do this through an exploration of Rio Tinto’s involvement in the WA Future Fund. This paper forms part of an introductory scoping case study of the Rio Tinto WA Future fund and its function as one of Rio Tinto’s diverse responses to community development issues in Western Australia.
Respiratory Motion Correction in 3-D PET Data With Advanced Optical Flow Algorithms

The problem of motion is well known in positron emission tomography (PET) studies. The PET images are formed over an elongated period of time. As the patients cannot hold breath during the PET acquisition, spatial blurring and motion artifacts are the natural result. These may lead to wrong quantification of the radioactive uptake. We present a solution to this problem by respiratory-gating the PET data and correcting the PET images for motion with optical flow algorithms. The algorithm is based on the combined local and global optical flow algorithm with modifications to allow for discontinuity preservation across organ boundaries and for application to 3-D volume sets. The superiority of the algorithm over previous work is demonstrated on software phantom and real patient data.
Optimization of Fault Monitoring Method Based on Acceleration Sensor

With the continuous progress of the space station project, the rotary mechanism is widely used in the space station. Serious failure of rotating mechanism can cause motor burnout and then safety problems. Therefore, it is necessary to monitor and diagnose rotating mechanism. The vibration signal of the rotating mechanism is nonlinear and non-stationary. Therefore, the acceleration sensor vibration signal is decomposed by CEEMD method to get the intrinsic mode function. Next, Fourier transform is used to obtain time-frequency information according to the obvious components of fault characteristics, and the information entropy of time-frequency information is calculated. The degree of dimensionality reduction about fault feature is determined by selecting the number of principal components through adaptive cumulative contribution. Finally, the fault feature is trained by support vector machine and tested with data. Experimental results show that the optimized method is less computational and can accurately extract fault feature information.
Identification of a 15-kDa cAMP-dependent Protein Kinase-anchoring Protein Associated with Skeletal Muscle L-type Calcium Channels*

Voltage-dependent potentiation of skeletal muscle L-type calcium channels requires phosphorylation by cAMP-dependent protein kinase (PKA) that is localized by binding to a cMP-dependent protein inase-nchoring rotein (AKAP). L-type calcium channels purified from rabbit skeletal muscle contain an endogenous co-purifying protein kinase activity that phosphorylates the α1 and β subunits of the channel. The co-purifying kinase also phosphorylates a known PKA peptide substrate, is stimulated by cAMP, and is inhibited by PKA inhibitor peptide-(5-24), indicating that it is PKA. PKA activity co-immunoprecipitates with the calcium channel, suggesting that the channel and the kinase are physically associated. Using biotinylated type II regulatory subunit of PKA (RII) as a probe, we have identified a 15-kDa RII-binding protein in purified calcium channel preparations, which we have designated AKAP-15. Anti-peptide antibodies directed against the α1 subunit of the calcium channel co-immunoprecipitate AKAP-15. Together, these findings demonstrate a physical link between PKA and the calcium channel and suggest that AKAP-15 may mediate their interaction.
De Novo Donor-Specific Human Leukocyte Antigen Antibodies in Nonsensitized Kidney Transplant Recipients After T Cell-Mediated Rejection

Background Local inflammation is a potential cause of humoral alloimmune responses in renal transplantation, and de novo donor-specific anti–human leucocyte antigen antibodies (dnDSAs) have been associated with a history of acute rejection. Methods We investigated the frequencies and consequences of dnDSAs after a first episode of acute T-cell–mediated rejection (index TCMR) in previously unsensitized kidney transplant recipients. Results Of the 1,054 patients who underwent kidney transplantation between September 2004 and December 2010 at our center, we identified 75 unsensitized patients with at least one TCMR. Index TCMRs were diagnosed 4.4 ± 6.8 months after transplantation. The dnDSAs were assessed using the highly sensitive single-antigen human leukocyte antigen bead assay 5.1 ± 3.9 months after the index TCMR and were detected in 16 patients (21%). Patients who developed dnDSAs were more likely to have experienced pre-transplant sensitizing events and were indistinguishable in their clinical, biologic, and histologic variables at the time of index TCMR, although the tubulitis scores tended to be higher (P = 0.079). These patients experienced a significantly higher incidence of subsequent antibody-mediated rejection episodes (P < 0.001), but reduced death-censored graft survival was not observed after a median follow-up of 5.5 years post-transplantation. Follow-up biopsies revealed increased antibody-mediated changes with significantly higher glomerulitis scores and numerically higher C4d staining scores. Conclusion Monitoring anti–human leukocyte antigen antibodies after cellular rejection may be useful, especially among patients with a history of pretransplant exposure to alloantigens, to predict subsequent humoral events and their consequences.
Cell-Type-Specific Regulation of Degradation of Hypoxia-Inducible Factor 1α: Role of Subcellular Compartmentalization

ABSTRACT The hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that mediates adaptive cellular responses to decreased oxygen availability (hypoxia). At normoxia, HIF-1α is targeted by the von Hippel-Lindau tumor suppressor protein (pVHL) for degradation by the ubiquitin-proteasome pathway. In the present study we have observed distinct cell-type-specific differences in the ability of various tested pVHL-interacting subfragments to stabilize HIF-1α and unmask its function at normoxia. These properties correlated with differences in subcellular compartmentalization and degradation of HIF-1α. We observed that the absence or presence of nuclear localization or export signals differently affected the ability of a minimal HIF-1α peptide spanning residues 559 to 573 of mouse HIF-1α to stabilize endogenous HIFα and induce HIF-driven reporter gene activity in two different cell types (primary mouse endothelial and HepG2 hepatoma cells). Degradation of HIF-1α occurred mainly in the cytoplasm of HepG2 cells, whereas it occurs with equal efficiency in nuclear and cytoplasmic compartments of primary endothelial cells. Consistent with these observations, green fluorescent protein-HIF-1α is differently distributed during hypoxia and reoxygenation in hepatoma and endothelial cells. Consequently, we propose that differential compartmentalization of degradation of HIF-1α and the subcellular distribution of HIF-1α may account for cell-type-specific differences in stabilizing HIF-1α protein levels under hypoxic conditions.
Starch‐binding domains in the CBM45 family – low‐affinity domains from glucan, water dikinase and α‐amylase involved in plastidial starch metabolism

Starch‐binding domains are noncatalytic carbohydrate‐binding modules that mediate binding to granular starch. The starch‐binding domains from the carbohydrate‐binding module family 45 (CBM45, http://www.cazy.org) are found as N‐terminal tandem repeats in a small number of enzymes, primarily from photosynthesizing organisms. Isolated domains from representatives of each of the two classes of enzyme carrying CBM45‐type domains, the Solanum tuberosumα‐glucan, water dikinase and the Arabidopsis thaliana plastidial α‐amylase 3, were expressed as recombinant proteins and characterized. Differential scanning calorimetry was used to verify the conformational integrity of an isolated CBM45 domain, revealing a surprisingly high thermal stability (Tm of 84.8 °C). The functionality of CBM45 was demonstrated in planta by yellow/green fluorescent protein fusions and transient expression in tobacco leaves. Affinities for starch and soluble cyclodextrin starch mimics were measured by adsorption assays, surface plasmon resonance and isothermal titration calorimetry analyses. The data indicate that CBM45 binds with an affinity of about two orders of magnitude lower than the classical starch‐binding domains from extracellular microbial amylolytic enzymes. This suggests that low‐affinity starch‐binding domains are a recurring feature in plastidial starch metabolism, and supports the hypothesis that reversible binding, effectuated through low‐affinity interaction with starch granules, facilitates dynamic regulation of enzyme activities and, hence, of starch metabolism.
Personally familiar faces are perceived categorically in face‐selective regions other than the fusiform face area

Neuroimaging studies of humans have provided inconsistent evidence with respect to the response properties of the fusiform face area (FFA). It has been claimed that neural populations within this region are sensitive to subtle differences between individual faces only when they are perceived as distinct identities [P. Rotshtein et al. (2005)Nature Neuroscience, 8, 107–113]. However, sensitivity to subtle changes of identity was found in previous studies using unfamiliar faces, for which categorical perception is less pronounced. Using functional magnetic resonance adaptation and morph continua of personally familiar faces, we investigated sensitivity to subtle changes between faces that were located either on the same or opposite sides of a categorical perceptual boundary. We found no evidence for categorical perception within the FFA, which exhibited reliable sensitivity to subtle changes of face identity whether these were perceived as distinct identities, or not. On the contrary, both the posterior superior temporal sulcus and prefrontal cortex exhibited categorical perception, as subtle changes between faces perceived as different identities yielded larger release from adaptation than those perceived as the same identity. These observations suggest that, whereas the FFA discriminates subtle physical changes of personally familiar faces, other regions encode faces in a categorical fashion.
Quantitative Progesterone Receptor Expression and Efficacy of Anti‐estrogen Therapy in Breast Cancer

The central role of estrogen receptor (ER) presence in predicting which breast cancer patients are likely to benefit from anti‐estrogen therapies is well‐established, but the added benefit of progesterone receptor (PR) and in particular low levels of PR is less well understood. The objective of this study was to determine the quantitative relationship between borderline levels of PR and subsequent benefit from anti‐estrogen therapy. We examined data from 447 patients, age 50 or older. ER and PR levels were quantitated by conventional ligand binding assay and Scatchard plot analysis or by enzyme‐linked immunoassay. Comparison of clinical outcome in relation with ER and PR status was calculated using Kaplan‐Meier actuarial survival analysis and the log‐rank test. Subpopulation treatment effect pattern plot (STEPP) analysis was used to explore the interaction between treatment effects and ER or PR levels for the 409 patients with ER values greater than 0. For anti‐estrogen treated patients, when the ER and PR positivity cut‐off was set at 1.0 fmole/mg protein, there was a statistically significant advantage for patients with ER+PR+ over ER+ PR− tumors for both breast cancer‐free interval (BCFI) and overall survival (OS). STEPP analysis found no overall interaction between treatment outcome (5 year survival probability) and levels of hormone receptor. However, patients with borderline PR levels did not appear to benefit from anti‐estrogen therapy. PR levels above borderline in addition to the presence of ER predicts an increased probability of benefit from anti‐estrogen therapy in breast cancer patients.
Personalized Medicine in a Phase I Clinical Trials Program: The MD Anderson Cancer Center Initiative

Purpose: We initiated a personalized medicine program in the context of early clinical trials, using targeted agents matched with tumor molecular aberrations. Herein, we report our observations. Patient and Methods: Patients with advanced cancer were treated in the Clinical Center for Targeted Therapy. Molecular analysis was conducted in the MD Anderson Clinical Laboratory Improvement Amendments (CLIA)–certified laboratory. Patients whose tumors had an aberration were treated with matched targeted therapy, when available. Treatment assignment was not randomized. The clinical outcomes of patients with molecular aberrations treated with matched targeted therapy were compared with those of consecutive patients who were not treated with matched targeted therapy. Results: Of 1,144 patients analyzed, 460 (40.2%) had 1 or more aberration. In patients with 1 molecular aberration, matched therapy (n = 175) compared with treatment without matching (n = 116) was associated with a higher overall response rate (27% vs. 5%; P < 0.0001), longer time-to-treatment failure (TTF; median, 5.2 vs. 2.2 months; P < 0.0001), and longer survival (median, 13.4 vs. 9.0 months; P = 0.017). Matched targeted therapy was associated with longer TTF compared with their prior systemic therapy in patients with 1 mutation (5.2 vs. 3.1 months, respectively; P < 0.0001). In multivariate analysis in patients with 1 molecular aberration, matched therapy was an independent factor predicting response (P = 0.001) and TTF (P = 0.0001). Conclusion: Keeping in mind that the study was not randomized and patients had diverse tumor types and a median of 5 prior therapies, our results suggest that identifying specific molecular abnormalities and choosing therapy based on these abnormalities is relevant in phase I clinical trials. Clin Cancer Res; 18(22); 6373–83. ©2012 AACR.
Synchronization Between Two Complex Dynamical Networks Using Scalar Signals Under Pinning Control

In this paper, a new scheme for synchronization between two or more complex networks is proposed using scalar signals under pinning control. Unlike common synchronization schemes, where all states of the driving networks are transmitted to the response network and all the nodes in the response network are required to be controlled, here, it is suggested that only a few nodes in the response network are controlled and only a few scalar signals are required to be transmitted from the driving network to the response one. Some criteria for synchronization between two or more complex dynamical networks are given in the form of linear matrix inequality. Furthermore, how to choose the pinned nodes according to the network topology is discussed by a numerical simulation method. Some typical network configurations are simulated, and the simulation results show that the proposed synchronization scheme is effective for the synchronization between two or more complex networks.
Epidermal Growth Factor Receptor and Estrogen and Progesterone Receptors in Breast Cancers of Premenopausal and Postmenopausal Patients

Aims and backround The purpose of our research was to investigate the relations between the levels of epidermal growth factor receptor and estrogen and progesterone receptors in breast cancers of premenopausal and postmenopausal Polish women. Methods Cell membrane levels of epidermal growth factor receptor (EGF-R), and cytosol (c) estrogen (ER) and progesterone (PR) receptors were determined in 221 specimens of primary breast cancers. ERc and PRc were assayed using the dextran-coated charcoal procedure, and EGF-R were assayed by the radioligand method of specific saturation of the crude membrane fraction with 125I-EGF Results A statistically significant inverse correlation was found in all tumors between the concentrations of EGF-R and ERc, whereas for PRc significance of this correlation was not fully confirmed. ERc concentrations in tumors were positively correlated with age of patients, whereas EGF-R and PRc were not. In all, in premenopausal, and in postmenopausal EGF-R-positive tumors (≥ 10 fmol/mg of membrane protein), mean concentrations of ERc did not differ significantly. These groups of tumors seem to be homogeneous with respect to ERc concentrations. In EGF-R-negative (< 10 fmol/mg of membrane protein) postmenopausal tumors, the mean ERc concentration was significantly higher than in premenopausal tumors, hence these groups of tumors appear to be heterogeneous with regard to ERc con tens: Conclusions The present findings may have significance in differentiation of postmenopausal breast cancer.
A parameter adaptive particle swarm optimization algorithm for extreme learning machine

In this paper, a learning algorithm called APSO-ELM for single hidden layer feed-forward neural networks is proposed, in which the input weights and hidden biases are determined by the parameter adaptive particle swarm optimization technique. The performance of the proposed algorithm is verified by simulation of four function approximation and classification benchmark problems. Simulation results show that the proposed algorithm has better global approximation performance and generalization capability. And for a better elucidation of the effectiveness of the proposed algorithm, the algorithm is applied to the robot execution failures problem. Compared with the original ELM algorithm and existing prediction methods of robot execution failures, the classification rate of the proposed algorithm significantly improved and in 10 times' simulation, the proposed algorithm has nine times 100% classification rate, which promotes the practical application of the algorithm in the field of robotics.