Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of a reporter gene interrupted by the Candida albicans group I intron is inhibited by base analogs.

We previously reported the identification of an intron (CaLSU) in the 25S ribosomal RNA of some Candida albicans yeast strains. CaLSU was shown to self-splice and has the potential to adopt a secondary structure typical of group I introns. The presence of CaLSU inC. albicans strains correlates with a high degree of susceptibility to base analog antifungal agents, 5-fluorocytosine (5-FC) or 5-fluorouracil (5-FU). Cell death, resulting from addition of base analogs to growing cultures, precluded demonstration of a causal relationship between CaLSU presence and susceptibility to base analogs. In the present study, CaLSU was inserted in a non-essential lacZ reporter gene and expression was examined in Saccharomyces cerevisiae. Different mutations affecting in vitro self-splicing also had similar effects on reporter gene expression in vivo. This indicates that in vivo removal of CaLSU from the reporter gene occurs through the typical self-splicing mechanism of group I introns. Base analogs inhibited expression of the reporter gene product in a concentration-dependent manner upon their addition to the cultures. This supports a model in which disruption of intron secondary structure, consecutive to the incorporation of nucleotide analogs, is a major factor determining the susceptibility of C.albicans cells to base analogs.
The Effect of Multi-mode Operations to Routing and Scheduling on Wireless Sensor Networks

This article develops a comprehensive model for optimal dat a re rieval using multimode wireless sensors in a network setting. The proposed max imum data retrieval (MDR) problem jointly optimizes routing and scheduling decision over time subject to spatial reuse and sensor resource (energy and storage) constraints . Optimal solutions to sample cases of the NP-Hard MDR problem leads to closed form models o f optimal store-andforward (S&F) operations and insights of energy efficient sc heduling and routing policies.
Sport in Britain, 1945-2000

Preface. 1. Playing and Watching. 2. Reconstruction, 1945--1952. 3. Amateurism. 4. The Professionals. 5. Media and Celebrity. 6. Civic and National Identity. 7. Governments and Sport. Conclusion. Bibliography. Index.
Rights vs. Responsibilities: The Supreme Court and the Media

Introduction: Rights and Responsibilities, Politics and Philosophies Functions and Canons: Defining Media Responsibility The Early Years--1931-1953 The Warren Court Years--1953-1969 The Centrist Years--1969-1981 The move to Conservatism--1981-1996 Positivism and Policy Appendix: Chronological Case List Bibliography Index
Development of a Separation and Detection System for Bacillus anthracis Spores Based on Peptide Conjugates Identified from Peptide Library

A simple, specific and rapid identification system against Bacillus anthracis spores was developed using specific capture peptides conjugated with a bead-based biosensor, which was tightly and specifically bound onto the spore surface of B. anthracis. We successfully detected and separated B. anthracis spores from the spores of B. thuringiensis and B. cereus using this peptide-magnetic bead conjugates by fluorescence and anthrax-specific analyses. For more convenient mediation of high-throughput detection against B. anthracis spores, streptavidin-biotin interactions of spore-peptide and spore-peptide-magnetic bead conjugates were performed, and we demonstrated the separation and detection of B. anthracis spores using this method. In the presence of mixed condition of several types of Bacillus spores, the B. anthracis spores were easily separated using the oligopeptide-conjugated magnetic beads, thus allowing the clear detection of B. anthracis spores from B. cereus, B. subtilis, and B. thuringiensis spores. This oligopeptidebased strategy was rapidly and unambiguously identified as little as one viable B. anthracis spore in less than 1 h with a simple binding assay format. When assessed for its effectiveness for specifically and selectively detection of environmental spores phylogenetically similar to B. anthracis spores, such as B. thuringiensis and B. cereus spores, the system was free of false-positive signals.
Dynamic Power Partitioning and Control for Performance Optimization in Chip Multiprocessors

Since power consumption has become a major constraint for the further throughput improvement of chip multiprocessors (CMPs), a key challenge is to optimize the performance of a CMP within a power budget limited by the CMP's cooling, packaging, and power supply capacities. Most existing solutions rely solely on dynamic voltage and frequency scaling (DVFS) to adapt the power consumption of CPU cores, without coordinating with on-chip L2 caches. However, dynamic cache resizing can be adopted to put rarely accessed cache ways into low-power modes, allowing power to be shifted to the CPU cores for improved performance. In this paper, we propose a novel chip-level power control strategy that can dynamically shift power among the CPU cores and shared L2 caches in a CMP based on the workload characteristics measured online, while maintaining the total power of the CMP below a given budget. Specifically, we implement an online model es-timator to dynamically measure the performance contributed by each core and the shared caches and then use linear programming to optimally partition the chip-level power budget among them. We then design power control algorithms based on feedback control theory for CPU cores and caches such that their power consumption is controlled to their respective local budgets. We compare our solution with several state-of-the-art power control solutions. Our extensive experimental results demonstrate that our solution achieves 10.2% better performance on average, in terms of instructions per cycle (IPC), than the best-performing baseline.
Development of a Serial Order in Speech Constrained by Articulatory Coordination

Universal linguistic constraints seem to govern the organization of sound sequences in words. However, our understanding of the origin and development of these constraints is incomplete. One possibility is that the development of neuromuscular control of articulators acts as a constraint for the emergence of sequences in words. Repetitions of the same consonant observed in early infancy and an increase in variation of consonantal sequences over months of age have been interpreted as a consequence of the development of neuromuscular control. Yet, it is not clear how sequential coordination of articulators such as lips, tongue apex and tongue dorsum constrains sequences of labial, coronal and dorsal consonants in words over the course of development. We examined longitudinal development of consonant-vowel-consonant(-vowel) sequences produced by Japanese children between 7 and 60 months of age. The sequences were classified according to places of articulation for corresponding consonants. The analyses of individual and group data show that infants prefer repetitive and fronting articulations, as shown in previous studies. Furthermore, we reveal that serial order of different places of articulations within the same organ appears earlier and then gradually develops, whereas serial order of different articulatory organs appears later and then rapidly develops. In the same way, we also analyzed the sequences produced by English children and obtained similar developmental trends. These results suggest that the development of intra- and inter-articulator coordination constrains the acquisition of serial orders in speech with the complexity that characterizes adult language.
Online regeneration of bipedal walking gait pattern optimizing footstep placement and timing

We propose a new algorithm capable of online regeneration of gait patterns. The algorithm uses a nonlinear optimization technique to find step parameters that will bring the robot from the present state to a desired state. It modifies online not only the footstep positions, but also the step timing in order to maintain dynamic stability during walking. Inclusion of step time modification extends the robustness against rarely addressed disturbances, such as pushes towards the stance foot. The controller is able to recover dynamic stability regardless of the source of the disturbance (e.g. model inaccuracy, reference tracking error or external disturbance). We describe the robot state estimation and center-of-mass feedback controller necessary to realize stable locomotion on our humanoid platform COMAN. We also present a set of experiments performed on the platform that show the performance of the feedback controller and of the gait pattern regenerator. We show how the robot is able to cope with series of pushes, by adjusting step times and positions.
The Impossible Duo? Globalization and Monetary Independence in Emerging Markets

Once upon a time it was the impossible trinity—countries could not have capital mobility, an independent monetary policy, and fixed exchange rates all at once.1 Now, according to the conventional wisdom that has emerged after the Mexican,Asian, Russian, and Turkish crises, it is the impossible duo. You cannot enjoy free capital movements and a countercyclical monetary policy, regardless of your exchange rate regime. The culprit, allegedly, is original sin—past misbehavior keeps the country from being able to borrow in its own currency, causing a pervasive dollarization of liabilities. In that context, pundits argue, a monetary expansion accompanied by a real depreciation can do more harm than good, causing debt-service costs to shoot up while bankrupting local banks and firms. Sinful nations that suffer an adverse shock are therefore simply advised to turn the other cheek. Many have, from Hong Kong in 1997 to Argentina today, with predictably painful consequences. So much religion is allegedly uplifting, but the economics behind the emerging orthodoxy is not always clear. This paper argues that the impossibility of the duo is much less clear-cut than the post-Asia discussion suggests. There are indeed situations—particularly if the economy is in the midst of a speculative attack, caused by a bout of pessimism that could be self-fulfilling—in which a policy-induced depreciation may turn out to be lethal. But there are many others—for instance, if the economy suffers an adverse export shock—
Innovation panel surveys in Germany

Surveying innovation activities of enterprises has a long tradition in Germany. The first largescale survey instrument dates back to 1979 when the Munichbased Ifo Institute introduced its ‘Ifo Innovation Test’. It used a methodology that was close to that later proposed in the Oslo Manual, distinguishing product and process innovation and collecting information on innovation activities and expenditure as well as some context information such as information sources for innovation, objectives of innovation activity and factors that hamper innovation. The survey is part of the Institute’s wider activities to collect information on business climate and expectations in the manufacturing sector. The sample of the Ifo Innovation Test is drawn from Ifo’s monthly business climate survey and is confined to the manufacturing sector (including mining and quarrying). Conducted annually since its start, the Ifo Innovation Test is probably the longestlasting innovation panel survey in the world.1 Although it has influenced the methodological work on innovation surveys, the Ifo Innovation Test does not fully apply the standards set by the Oslo Manual or those by the EU Commission’s regulation on innovation statistics, which restricts international comparison. In addition, the survey’s size is confined to about 1000 observations per year, which further limits its analytical potential in terms of sector breakdown. In order to set up a survey that fully complied with the Oslo Manual (OECD 1992) and that could contribute to the then newly established Community Innovation Surveys (CIS), another innovation panel survey was introduced in Germany in 1993, the Mannheim Innovation Panel (MIP). This survey got its name from the city where the organization that conducts the survey is located, which is the Centre for European Economic Research (ZEW). 2 Commissioned by the Federal Ministry of Education and Research (BMBF), the MIP covers all production sectors (including mining, energy and water supply and construction) and a large number of service sectors, including trade, transportation, financial intermediation and businessrelated services. While the MIP shares many features of other national CIS, it holds some distinct characteristics that may make it worth discussing the experience gained from this survey instrument in
Financial reporting risk assessment and audit pricing

Financial information that has being deteriorated by fraud will misled users. Hence, the main objective of this paper is to identify the association between five ratios of financial reporting risks to predict fraud. Furthermore, this paper also investigates the impacts of fraud detection on audit fee. Thus, sample of 10 of fraudulent companies and sample of 40 non fraudulent companies are being identified to achieve the objective. Stepwise logistic regression was being employed. The results clearly indicate that changes in sales, receivables and allowance for doubtful debts have significant effect of fraud detection. However, fraud detection gives no or little impact on audit fees.
Fabric defect detection by Fourier analysis

Many fabric defects are very small and undistinguishable, which are very difficult to detect by only monitoring the intensity change. Faultless fabric is a repetitive and regular global texture and Fourier transform can be applied to monitor the spatial frequency spectrum of a fabric. When a defect occurs in fabric, its regular structure is changed so that the corresponding intensity at some specific positions of the frequency spectrum would change. However, the three-dimensional frequency spectrum is very difficult to analyze. In this paper, a simulated fabric model is used to understand the relationship between the fabric structure in the image space and in the frequency space. Based on the three-dimensional frequency spectrum, two significant spectrum diagrams are defined and used for analyzing the fabric defect. These two diagrams are called the central spatial frequency spectrums. The defects are broadly classified into four classes: (1) double yarn; (2) missing yarn; (3) webs or broken fabric; and (4) yarn densities variation. After evaluating these four classes of defects using some simulated models and real samples, seven characteristic parameters for central spatial frequency spectrum are extracted for defect classification.
Experiments in TREC 2004 Novelty Track at CAS-ICT

The main task in Novelty Track is to retrieve relevant sentences and remove duplicates from a document set given a TREC topic. This track took place for the first time in TREC 2002 and it is refined to four tasks in TREC 2003. Besides 25 relevant documents, irrelevant ones are given in this year of Novelty track. In other words, a given document is either relevant or irrelevant to the topic. There are 1808 documents in 50 TREC topics. Average 11.18 documents are noise for each topic. In topic N75, the number of noise is 45. Once we mistook an irrelevant document as relevance, all results in the document are wrong. Except the document retrieval, more limited information could be applied in the last three tasks than ever. Among the first 5 given documents, average 3.14 documents are relevant and average 2.76 are new. Especially, 9 topics have no relevant sentence in the first 5 ones. In TREC2004, ICT divided Novelty track into four sequential stages. It includes: customized language parsing on original dataset, document retrieval, sentence relevance and novelty detection. The architecture in novelty is given in Figure 1. In the first preprocessing stage, we applied sentence segmenter, tokenization, part-of-speech tagging, morphological analysis, stop word remover and query analyzer on topics and documents. As for query analysis, we categorized words in topics into description words and query words. Title, description and narrative parts are all merged into query with different weights. In the stage of document and sentence retrieval, we introduced vector space model (VSM) and its variance, probability model OKAPI and statistical language model. Based on VSM, we tried various query expansion strategies: pseu-feedback, term expansion with synset or synonym in WordNet[1] and expansion with highly local co-occurrence terms. With regard to the novelty stage, we defined three types of new degree: word overlapping and its extension, similarity comparison and information gain. In the last three tasks, we used the known results to adjust threshold, estimate the number of results, and turned to classifier, such as inductive and transductive SVM. Topic/Doc Parsing
Implied Distribution as a Function of the Volatility Smile

The aim of this paper is to obtain the risk-neutral density of an underlying asset price as a function of its option implied volatility smile. We derive a known closed form non-parametric expression for the density and decompose it into a sum of lognormal and adjustment terms. By analyzing this decomposition we also derive two no-arbitrage conditions on the volatility smile. We then explain how to use the results. Our methodology is applied first to the pricing of a portfolio of digital options in a fully smile-consistent way. It is then applied to the fitting of a parametric distribution for log-return modelling, the Normal Inverse Gaussian.
Regulation of DNA repair in serum-stimulated xeroderma pigmentosum cells

The regulation of DNA repair during serum stimulation of quiescent cells was examined in normal human cells, in fibroblasts from three xeroderma pigmentosum complementation groups (A, C, and D), in xeroderma pigmentosum variant cells, and in ataxia telangiectasia cells. The regulation of nucleotide excision repair was examined by exposing cells to ultraviolet irradiation at discrete intervals after cell stimulation. Similarly, base excision repair was quantitated after exposure to methylmethane sulfonate. WI-38 normal human diploid fibroblasts, xeroderma pigmentosum variant cells, as well as ataxia telangiectasia cells enhanced their capacity for both nucleotide excision repair and for base excision repair prior to their enhancement of DNA synthesis. Further, in each cell strain, the base excision repair enzyme uracil DNA glycosylase was increased prior to the induction of DNA polymerase using the identical cells to quantitate each activity. In contrast, each of the three xeroderma complementation groups that were examined failed to increase their capacity for nucleotide excision repair above basal levels at any interval examined. This result was observed using either unscheduled DNA synthesis in the presence of 10 mM hydroxyurea or using repair replication in the absence of hydroxyurea to quantitate DNA repair. However, each of the three complementation groups normally regulated the enhancement of base excision repair after methylmethane sulfonate exposure and each induced the uracil DNA glycosylase prior to DNA synthesis. These results suggest that there may be a relationship between the sensitivity of xeroderma pigmentosum cells from each complementation group to specific DNA damaging agents and their inability to regulate nucleotide excision repair during cell stimulation.
A privacy preserving clustering technique using hybrid data transformation method

Despite many successful stories of data mining in a wide range of applications, this technique has raised some issues related to privacy and security of individuals. Due to these issues, data owners are often unwilling to share their sensitive information with data miners. In this paper, we present a novel method for privacy preserving clustering over centralized data. The proposed method is built upon the application of Double-Reflecting Data Perturbation Method (DRDP) and Rotation Based Translation (RBT) in order to provide secrecy of confidential numerical attributes without losing accuracy in results. The experiments demonstrate that the proposed method is effective and provides a feasible approach to balancing privacy and accuracy.
Paperscope : Chronicling the History of Computer Architecture Research

Computer architecture, like many other well established research fields, has witnessed periodic trends in research interests. Certain research topics transcend the test of time, while others enjoy surges in popularity followed by a period of decline and interest. However, there is little actual data that corroborates or rebukes these patterns of popularity within our community. To substantiate these observations, we use latent Dirichlet allocation (LDA) to build a topic model over all publications from three top tier computer architecture conferences up until 2015. Our results show that LDA provides an excellent method for chronicling the trajectory of the computer architecture research community, and accurately quantifies historical trends and patterns in computer architecture research.
Institutionalization and organizational long-term success

Institutionalization processes have an ambivalent effect on organizational long-term success. Even though they foster organizational stability and permanence, they also bring about rigidity and resistance to change. As a result, successful organizations are likely to lose their competitive advantage over time. The paper addresses this issue through the investigation of the institutionalization processes of two long-lived companies: General Electric, a firm that has been a long-term success and its rival, Westinghouse, which was broken up after eleven decades of existence. The longitudinal, multilevel analysis of firms and industry has identified two different modes of organizational institutionalization. The reactive mode gives rise to rigidity and change resistance, much like institutional theory predicts; the proactive mode, on the other hand, neutralizes those negative effects of institutionalization processes. In the reactive mode, structure predominates. In the proactive mode, agency plays a major role in organizational institutionalization, and in managing the organization's relations with the environment, clearly contributing to environmental institutionalization.
Compact Marx generators modified for fast risetime

Traditionally, the 1.6-MV Marx generator offered by APELC operates at a charge voltage of 40 kV, an erected voltage of 1.6 MV, a stored energy of 260 J, and an output pulse rise time between 6-8 ns. APELC has developed a pulse conditioning system (PCS) that can be retrofitted into the existing MV Marx generator housing to improve output pulse rise time at a minimal cost of stored energy. The performance characteristics of the newly developed PCS driven by a slightly modified version of APELC's MV Marx generator will be provided. APELC has also retrofitted its staple 15-stage, 33-J, Marx generator with a scaled version of the same PCS. Preliminary results of the scaled version of the PCS are presented as well.
Simple perception-action strategy based on hierarchical temporal memory

This paper presents a simple strategy for perception-action of robots in indoor environments using Hierarchical Temporal Memory which is the theory of modeling the rationale of the neocortex. The main idea of the present study is that the input of the HTM network is images of objects that robot perceives in environment, and the output of HTM network is action, such as moving along the wall, moving away, opening, and moving forward, etc. Experiments results show that the proposed method can be applied for robot learning and navigation because it imitates humans' thinking mode to process the information it receives.