Miracle-dz/UniFAR-FTUs huggingface dataset:
Crystal structure of methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087) at 2.2 Å resolution

Introduction. The enzyme 5,10-methenyltetrahydrofolate synthetase (MTHFS), also known as 5-formyltetrahydrofolate cyclo-ligase, is involved in folate metabolism. MTHFS catalyzes the obligatory initial metabolic step in the intracellular irreversible conversion of 5-formyltetrahydrofolate to other reduced folates, which requires ATP and magnesium. The product is then interconverted into other reduced folates involved in one-carbon metabolism. The reduced tetrahydrofolates (THFs) serve as cofactors that carry one-carbon moieties for the de novo synthesis of purines (supply the number 2 and number 8 carbons of the purine ring) and thymidylate (used for the methylation of dUMP to dTMP), and for the remethylation of homocysteine to methionine. Methionine can be adenylated to form S-adenosylmethionine, a cofactor and one-carbon donor for numerous cellular methylation reactions. The substrate of MTHFS, 5-formyltetrahydrofolate (5-FTHF), is used in chemotherapy (clinically known as Leucovorin), either to rescue patients from methotrexate toxicity or to enhance the effectiveness of 5-fluorouracil. MTHFS from Mycoplasma pneumoniae shares significant sequence homology with human MTHFS. Although sequence information for MTHFS from various organisms is available, no structural information for this family of enzymes has been obtained. To provide a structural basis for understanding the function of the MTHFS protein family, we have determined the crystal structure of M. pneumoniae MTHFS at 2.2 Å resolution.
E-Service Innovation in Rural Africa Through Value Co-Creation

E-Services have great potential, even in resource-poor environments such as in sub-Saharan Africa. However, contextual factors pose significant challenges for development, feasibility, deployment and sustainability of e-services. This chapter presents a case of e-service value co-creation in a rural context, with targeted end users in regions characterized by limited electricity infrastructure and poor or absent internet, strong diversity in languages spoken, high illiteracy rates and limited purchasing power. It offers a methodology to upfront analyze business model sustainability for e-service innovation in severely resource-constrained contexts. This is illustrated by an extensive case study in which a voice-based microblogging e-service was developed and deployed with local stakeholders in rural Mali.
Isolation and characterization of microsatellite markers in the endangered species Taxus wallichiana using the FIASCO method.

The Himalayan yew, Taxus wallichiana Zucc. , is an endangered species with a scatted distribution in the Eastern Himalayas and southwestern China. In the present study, 10 microsatellite markers from the genome of T. wallichiana were developed using the protocol of fast isolation by amplified fragment length polymorphism of sequences containing repeats (FIASCO). Polymorphism of each locus was assessed in 28 samples from four wild populations of the Himalayan yew. The allele number of the microsatellites ranged from two to five with an average of 2.9 per allele. The observed and expected heterozygosity varied from 0.00 to 1.00 and from 0.3818 to 0.7552, respectively. Cross-species amplification in another two yew species showed eight of them holding promise for sister species. Two of the 10 loci (TG126 and TC49) significantly deviated from Hardy-Weinberg expectations. No significant linkage disequilibrium was detected between the comparisons of these loci. These polymorphic microsatellite markers would be useful tools for population genetics studies and assessing genetic variations to establish conservation strategy of this endangered species.
Notice of RetractionLogistics service quality evaluation on logistics park

Logistics parks as infrastructures promoting modern logistics, have an extremely important role in the modern logistics system. This article firstly analyses the logistics services process of logistics parks, and finds out the elements of logistics services quality. Then, the paper designs a service quality evaluation model through analytic hierarchy process and fuzzy comprehensive evaluation methods. The evaluation model could help the enterprises to understand the logistics quality level, identify the factors affecting their level of service and problems existing in service process, and finally provide evidence for enterprises to improve operational efficiency and service quality.
Where Knowledge Management Resides within Project Management

EXECUTIVE SUMMARY This chapter explores how an engineering consulting company creates, manages, and reuses knowledge within its projects. It argues that the informal transfer and reuse of knowledge plays a more crucial role than formal knowledge in providing the greatest benefit to the organization. The culture of the organization encourages a reliance on networks (both formal and informal) for the exchange of tacit knowledge, rather than utilizing explicit knowledge. This case study highlights the importance of understanding the drivers of knowledge transfer and reuse in projects. This will provide researchers with an insight into how knowledge management integrates with project management.
A pr 2 01 5 Structure and Dynamics of the Instantaneous Water / Vapor Interface Revisited by Path-Integral and Ab-Initio Molecular Dynamics Simulations

The structure and dynamics of the water/vapour interface is revisited by means of path-integral and second-generation Car-Parrinello ab-initio molecular dynamics simulations in conjunction with an instantaneous surface definition [A. P. Willard and D. Chandler, J. Phys. Chem. B 114, 1954 (2010)]. In agreement with previous studies, we find that one of the OH bonds of the water molecules in the topmost layer is pointing out of the water into the vapor phase, while the orientation of the underlying layer is reversed. Therebetween, an additional water layer is detected, where the molecules are aligned parallel to the instantaneous water surface.
Factors affecting the adoption of mobile money services in the banking and financial industries of Botswana

This study set out to investigate factors affecting the adoption of mobile money services in the banking and financial industries of Botswana in the light of the Technology Acceptance Model (TAM) and demographic variables (that is, age of individuals, income, education level, bank account) from mobile money service adoption literature. To do this, a likert-like closed-ended questionnaire was administered to a total of 190 respondents from a targeted sample of 200 users and non-users of mobile banking services from four regions in Gaborone-Botswana. To ensure diversity in terms of demographic characteristics, stratified random sampling was done. The analysis of the results revealed that gross income and ownership of bank accounts appeared to be insignificant in determining the use of mobile money services in Botswana. However, the age of individuals did seem to be significant in determining whether an individuai used mobile money services or not, with more young people preferring to use mobile money services than older people. The education of individuals generally did not show any influence on the preference to use mobile money services to access banking and financial services. Sex/gender was shown to be significant with more males than females using mobile money services. Employment status was also significant with more employed individuals preferring to use mobile money services to access banking and financial services than unemployed. This study has therefore shown that, despite the lower penetration and absorption of mobile banking services in Botswana, indicators are that mobile banking is increasingly being adopted in Botswana especially by males, employed individuals and the youth. This is encouraging since mobile banking has the potential to improve access to financial and banking services in Botswana.
A simple body-limb coordination model that mimics primitive tetrapod walking

The coordination of body and limbs motions contributes to effective propulsion in limed locomotion. However, there is lack of understanding that characterizes the mechanism underlying the body-limb coordination. The aim of this study involves clarifying the mechanism through mathematical modeling and dynamic simulation. To this end, a body-limb coordination model was designed based on a simple rule by effectively using a pivot turn. The model successfully generated locomotion similar to primitive tetrapod walking, e.g. salamander and Polypterus walking based on their physical properties.
Corporate Culture: The Interview Evidence

We conduct in-depth interviews of senior executives representing over 20% of the market capitalization of the U.S. equity market to understand: (i) the importance, antecedents and consequences of corporate culture; (ii) the mechanisms that underlie the creation and effectiveness of corporate culture; as well as (iii) the factors that deter a firm from achieving its aspirational culture. Our interviews provide the following insights. First, executives characterize culture as “a beliefs system,” “a coordination mechanism,” and “an invisible hand. ” Second, most executives view culture as one of the top three factors that affect their firm’s value. Cultural fit in MA instead, they influence the choice of culture by picking the CEO and through their influence on specific policies like incentive compensation, hiring, firing, and promotion decisions, and the values the finance function embraces. Fifth, executives emphasize that for a firm’s culture to be effective, the firm’s espoused values must be backed up by actual behavior and norms. Sixth, an effective culture improves firm value and profitability by (i) fostering creativity and encouraging productivity; (ii) promoting more risk tolerance; (iii) mitigating myopic behavior; (iv) creating a climate for suggesting critiques and for allowing ideas to germinate organically; and (v) by compensating for mistakes in ways that the firm’s assets cannot. In addition to the above, executives suggest several sources of publicly available data to measure corporate culture.See our related paper Corporate Culture: Evidence from the Field.
Building class-based language models with contextual statistics

Novel clustering algorithms are proposed by using the contextual statistics of words for class-based language models. The minimum discriminative information (MDI) is used as a distance measure. Three algorithms are implemented to build bigram language models for a vocabulary of 50000 words over a corpus of over 200 million words. The computational cost of the algorithms and the resulting LM perplexity are studied. The comparisons between the MDI algorithm and the maximum mutual information algorithm are also given to demonstrate the effectiveness and the efficiency of the new algorithms. It is shown that the MDI approaches make the tree-building clustering possible with large vocabulary.
eWOM Marketing in Hospitality Industry

Due to its intangible nature, hospitality business finds it difficult to market its services. Past customer experiences are one of the best strategies that allow some quantification of the quality of the product. Word of mouth has been a key part of every effective marketing strategy for hospitality businesses. It is widely recognized that word of mouth, both positive and negative, has the potential to influence customer purchase decisions. With the technological advancement, the internet has been widely applied in various areas in the hospitality industry. Social media and the growth of web 2.0 have enabled word of mouth to be shared amongst millions of potential customers, one therefore can argue that electronic word of mouth (eWOM) has been the successor of the traditional word of mouth. Therefore, traditional Word-of-Mouth, which spread from person to person vocally has been replaced gradually by electronic Word-of-Mouth (eWOM). A growing trust on eWOM for making choices about hospitality products prompted the author to work on the present chapter.
Performance Measurement: A Stakeholder Approach

It is important that companies maintain their contractual relationships with their stakeholder groups. Therefore, a companyâ€™s strategy needs to accommodate these relation-ships and, consequently, there is a need for appropriate performance measurement to deter-mine how well the company serves its stakeholders. Based on a literature review, this paper seeks to observe current performance measurement models from the view of stakeholder theo-ry. Although broader performance measurement models have been introduced in response to the existence of stakeholders, these models still rely on financial indicators as primary measures whilst using operational indicators as complementary measures. However, these measures have recognized the importance of business performance not only to measure cur-rent outcomes, but also to influence future outcomes. Problems in implementing broader measures of performance include identification of relevant variables, relating action and re-sults, and translation of projects and activities into measurable terms. Keywords: stakeholder, performance measurement, maintaining quality
The status of research on leadership in business process management: A call for action

Business Process Management is recognised as a holistic management strategy aimed at achieving higher performance by optimising business processes. BPM projects require high commitment and leadership capabilities. Leadership has constantly been recognised as one of the critical success factors of BPM projects. However, the nature and characteristics of leadership in BPM are relatively under-researched areas. This paper presents the outcomes of a systematic literature review on leadership in BPM. While our review confirms a strong consensus on the importance of leadership in BPM, it also depicts the dearth of research in this area. We present a detailed analysis on the key themes observed within the current research with identified gaps and a call for action with a recommended research agenda.
The Price of Commodity Risk in Stock and Futures Markets

We find that commodity risk is priced in the cross-section of US stock returns. Following the financialization of commodities, investors hedge commodity price risk directly in the futures market, primarily via commodity index investments, whereas before they gained commodity exposure mainly via the stock market. As a result, we find that the annualized average returns of high-minus-low commodity beta stocks change from -8% pre-financialization to 11% post-financialization. As stock market investors increasingly participate in commodity futures markets, stock market risk is also priced in the cross-section of commodity futures returns.
Depressive symptoms and alcohol correlates among Brazilians aged 14 years and older : a cross-sectional study Substance Abuse Treatment

Background: The associations between depressive symptoms and alcohol-related disorders, drinking patterns and other characteristics of alcohol use are important public health issues worldwide. This study aims to study these associations in an upper middle-income country, Brazil, and search for related socio-demographic correlations in men and women. Methods: A cross-sectional study was conducted between November 2005 and April 2006. The sample of 3,007 participants, selected using a multistage probabilistic sampling method, represents the Brazilian population aged 14 and older. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale and alcohol dependence was assessed using the Composite International Diagnostic Interview. Associations assessed using bi-variate analysis were tested using Rao-Scott measures. Gender specific multinomial logistic regression models were developed. Results: Among the participants with alcohol dependence, 46% had depressive symptoms (17.2% mild/moderate and 28.8% major/severe; p < 0.01); 35.8% (p = 0.08) of those with alcohol abuse and 23.9% (p < 0.01) of those with a binge-drinking pattern also had depressive symptoms. Alcohol abstainers and infrequent drinkers had the highest prevalence of major/severe depressive symptoms, whereas frequent heavy drinkers had the lowest prevalence of major/severe depressive symptoms. In women, alcohol dependence and the presence of one or more problems related to alcohol consumption were associated with higher risks of major/severe depressive symptoms. Among men, alcohol dependence and being ≥45 years old were associated with higher risks of major/severe depressive symptoms. Conclusions: In Brazil, the prevalence of depressive symptoms is strongly related to alcohol dependence; the strongest association was between major/severe depressive symptoms and alcohol dependence in women. This survey supports the possible association of biopsychosocial distress, alcohol consumption and the prevalence of depressive symptoms in Brazil. Investing in education, social programs, and care for those with alcohol dependence and major/severe depressive symptoms, especially for such women, and the development of alcohol prevention policies may be components of a strategic plan to reduce the prevalence of depression and alcohol problems in Brazil. Such a plan may also promote the socio-economic development of Brazil and other middle-income countries.
Realism of Rainfall in a Very High-Resolution Regional Climate Model

AbstractThe realistic representation of rainfall on the local scale in climate models remains a key challenge. Realism encompasses the full spatial and temporal structure of rainfall, and is a key indicator of model skill in representing the underlying processes. In particular, if rainfall is more realistic in a climate model, there is greater confidence in its projections of future change.In this study, the realism of rainfall in a very high-resolution (1.5 km) regional climate model (RCM) is compared to a coarser-resolution 12-km RCM. This is the first time a convection-permitting model has been run for an extended period (1989–2008) over a region of the United Kingdom, allowing the characteristics of rainfall to be evaluated in a climatological sense. In particular, the duration and spatial extent of hourly rainfall across the southern United Kingdom is examined, with a key focus on heavy rainfall.Rainfall in the 1.5-km RCM is found to be much more realistic than in the 12-km RCM. In the 12-km RCM, hea.
Intracranial Ependymomas in Children: The Role of Surgery And Adjuvant Treatment

The management of pediatric intracranial meningiomas poses a big challenge. We are presenting the role of extent of tumor resection and adjuvant therapy in the survival of children with ependymomas. This is a retrospective study of 56 children with non-metastatic intracranial ependymomas treated between 2010 and 2015.The mean age was 8 years ranging between 3 months and 15 years.The most frequent location was infra tentorial location in 67.8% of patients. Total tumor resection was possible in 42.8% (25 patients)while partial resection was performed in 35.7%More than half of the patients were between WHO histological grade I and II (Grade I: 12 patients and Grade II: 18 patients) while 44.6% of tumors were anaplasic ependymomas (Grade III: 25 patients). More than half of the patients have received radiotherapy as initial adjuvant treatment (55.3%), while less than half of all patients have received chemotherapy (21.4%). Four children have received radiotherapy and chemotherapy.Morbidity experienced included six patients CSF leakage, four patients meningitis and nine patients with neurologic deterioration, 2 patients with seizures and 2 patients with intraventricular hemorrhage. There were four deaths after 38 months follow up and all our patients were followed up for 05 years.
Viral Shedding and Environmental Cleaning in Middle East Respiratory Syndrome Coronavirus Infection

Viral shedding lasted 31 and 19 days from symptom onset in two patients with east respiratory syndrome coronavirus (MERS-CoV) pneumonia, respectively. Environmental real-time RT-PCR was weakly positive for bed guardrail and monitors. Even after cleaning the monitors with 70% alcohol-based disinfectant, RT-PCR was still weakly positive, and converted to negative only after wiping with diluted sodium chlorite. Further studies are required to clarify the appropriate methods to clean environments during and after treatment of patients with MERS-CoV infection.
UKIRT Widefield Infrared Survey for H2

Abstract We perform an unbiased search for outflows from YSOs along the Galactic Plane (GP). Our data has been taken as part of the UWISH2 survey (Froebrich et al. 2011). It uses as tracer the 1-0S(1) emission line of H2, and here we focus on a continuous 33 square degree sized region in Serpens and Aquila. We identify 130 outflows from which 94% are new discoveries. Thus, we increased the number of known MHOs by a factor of 15 in this area (Ioannidis & Froebrich 2012). The flux completeness limit for the flows is 3ċ10−18Wm−2. Typically, the known flows occupy the bright end of the flux distribution. Our survey thus increases the known integrated 1-0S(1) H2 flux from outflows only by a factor of two. We are able to assign possible driving sources to half of the outflows. Brighter MHOs are more likely to have a source candidate assigned to them. Foreground star counts to GMCs associated with the outflows and the Besancon Galaxy model are used to determine distances. The method is calibrated using objects from the RMS survey. This allows us to estimate distances with a scatter of 25% (Ioannidis & Froebrich 2012). The spatial distribution of the outflows shows that they follow the GMC complexes in the GP. However, there are large areas with high extinction where no flows are detected. About 2/3 of the survey area is more or less devoid of outflows. The flows typically occur in groups of 3–5 members with a size of 5pc. The scale height of flows is ∼25–30pc, similar to young clusters and OB stars. The 1-0S(1) luminosities range from a few 10−4L⊙ to 0.1L⊙, ten times brighter than in nearby SF regions. Our sample is complete for objects brighter than 10−3L⊙ at 5kpc. This corresponds to HH211 behind AK = 1mag. The luminosity distribution of the outflows is a power law with N ∝ LH2−1.9 and the integrated luminosities indicate a Milky Way SF rate (averaged over a typical jet lifetime) of more than 0.4M⊙yr−1. The energy and momentum of the jets is insufficient to sustain the typical local turbulence levels in their parental clouds. The projected jet length drops exponentially in number for longer jets. The fraction of parsec scale flows is 25%, twice as high as in nearby SF regions. A Monte-Carlo type model of jet speeds of 40–130kms−1 and ages between 4–20 × 103yrs can reproduce the length distribution. These lifetimes are an order of magnitude below estimates for the protostellar phase. For typical jet speeds the time gaps between the ejection of larger amounts of material are about 103yrs. According to the burst mode of SF models the creation of H2 knots is hence linked to low level fluctuations of the mass accretion rate and not FU-Ori type events. Their duty cycle is more in agreement with the total jet lifetime, which suggests these outburst as trigger (or stopping point or both) of a jet ejection phase. However, better constraints of the FU-Ori duty cycle and mechanism as well as more detailed models are required to draw any further conclusions.