Miracle-dz/UniFAR-FTUs huggingface dataset:
High-power CMUTs: design and experimental verification

Capacitive micromachined ultrasonic transducers (CMUTs) have great potential to compete with piezoelectric transducers in high-power applications. As the output pressures increase, nonlinearity of CMUT must be reconsidered and optimization is required to reduce harmonic distortions. In this paper, we describe a design approach in which uncollapsed CMUT array elements are sized so as to operate at the maximum radiation impedance and have gap heights such that the generated electrostatic force can sustain a plate displacement with full swing at the given drive amplitude. The pro- posed design enables high output pressures and low harmonic distortions at the output. An equivalent circuit model of the array is used that accurately simulates the uncollapsed mode of operation. The model facilities the design of CMUT parameters for high-pressure output, without the intensive need for computationally involved FEM tools. The optimized design requires a relatively thick plate compared with a conventional CMUT plate. Thus, we used a silicon wafer as the CMUT plate. The fabrication process involves an anodic bonding process for bonding the silicon plate with the glass substrate. To eliminate the bias voltage, which may cause charging problems, the CMUT array is driven with large continuous wave signals at half of the resonant frequency. The fabricated arrays are tested in an oil tank by applying a 125-V peak 5-cycle burst sinusoidal signal at 1.44 MHz. The applied voltage is in- creased until the plate is about to touch the bottom electrode to get the maximum peak displacement. The observed pressure is about 1.8 MPa with -28 dBc second harmonic at the surface of the array.
Singular Vectors in Logarithmic Conformal Field Theories Mic h̄ ael

Null vectors are generalized to the case of indecomposable representations which are one of the main features of logarithmic conformal field theories. This is done by developing a compact formalism with the particular advantage that the stress energy tensor acting on Jordan cells of primary fields and their logarithmic partners can still be represented in form of linear differential operators. Since the existence of singular vectors is subject to much stronger constraints than in regular conformal field theory, they also provide a powerful tool for the classification of logarithmic conformal field theories. ∗email: flohr@sns.ias. edu
Interfacing polymeric scaffolds with primary pancreatic ductal adenocarcinoma cells to develop 3D cancer models

We analyzed the interactions between human primary cells from pancreatic ductal adenocarcinoma (PDAC) and polymeric scaffolds to develop 3D cancer models useful for mimicking the biology of this tumor. Three scaffold types based on two biocompatible polymeric formulations, such as poly(vinyl alcohol)/gelatin (PVA/G) mixture and poly(ethylene oxide terephthalate)/poly(butylene terephthalate) (PEOT/PBT) copolymer, were obtained via different techniques, namely, emulsion and freeze-drying, compression molding followed by salt leaching, and electrospinning. In this way, primary PDAC cells interfaced with different pore topographies, such as sponge-like pores of different shape and size or nanofiber interspaces. The aim of this study was to investigate the influence played by the scaffold architecture over cancerous cell growth and function. In all scaffolds, primary PDAC cells showed good viability and synthesized tumor-specific metalloproteinases (MMPs) such as MMP-2, and MMP-9. However, only sponge-like pores, obtained via emulsion-based and salt leaching-based techniques allowed for an organized cellular aggregation very similar to the native PDAC morphological structure. Differently, these cell clusters were not observed on PEOT/PBT electrospun scaffolds. MMP-2 and MMP-9, as active enzymes, resulted to be increased in PVA/G and PEOT/PBT sponges, respectively. These findings suggested that spongy scaffolds supported the generation of pancreatic tumor models with enhanced aggressiveness. In conclusion, primary PDAC cells showed diverse behaviors while interacting with different scaffold types that can be potentially exploited to create stage-specific pancreatic cancer models likely to provide new knowledge on the modulation and drug susceptibility of MMPs.
Detection of Sindbis and Inkoo Virus RNA in Genetically Typed Mosquito Larvae Sampled in Northern Sweden

Abstract Introduction: Mosquito-borne viruses have a widespread distribution across the globe and are known to pose serious threats to human and animal health. The maintenance and dissemination of these viruses in nature are driven through horizontal and vertical transmission. In the temperate climate of northern Sweden, there is a dearth of knowledge on whether mosquito-borne viruses that occur are transmitted transovarially. To gain a better understanding of mosquito-borne virus circulation and maintenance, mosquito larvae were sampled in northern Sweden during the first and second year after a large outbreak of Ockelbo disease in 2013 caused by Sindbis virus (SINV). Materials and Methods: A total of 3123 larvae were sampled during the summers of 2014 and 2015 at multiple sites in northern Sweden. The larvae were homogenized and screened for viruses using RT-PCR and sequencing. Species identification of selected larvae was performed by genetic barcoding targeting the cytochrome C oxidase subunit I gene. Results and Discussion: SINV RNA was detected in mosquito larvae of three different species, Ochlerotatus (Oc.) communis, Oc. punctor, and Oc. diantaeus. Inkoo virus (INKV) RNA was detected in Oc. communis larvae. This finding suggested that these mosquitoes could support transovarial transmission of SINV and INKV. Detection of virus in mosquito larva may serve as an early warning for emerging arboviral diseases and add information to epidemiological investigations before, during, and after outbreaks. Furthermore, our results demonstrated the relevance of genetic barcoding as an attractive and effective method for mosquito larva typing. However, further mosquito transmission studies are needed to ascertain the possible role of different mosquito species and developmental stages in the transmission cycle of arboviruses.
Motor evoked potentials in a rhesus macaque model of neuro-AIDS.

Previous work using bone marrow passaged SIVmac239 (simian immunodeficiency virus) has shown that macrophage tropic strains of this virus enter the rhesus macaque brain early following inoculation (Sharma et al, 1992; Desrosiers et al, 1991; Zhu et al, 1995; and Narayan et al, 1997). As part of an effort to more fully characterize the extent of neurologic impairment associated with SIV infection of the brain, we used transcranial electrical stimulation of motor cortex and the spinal cord to evoke EMG potentials in two forelimb (EDC and APB) and two hindlimb (LG and AH) muscles. The latencies, magnitudes and thresholds of motor evoked potentials (MEPs) recorded from nine monkeys infected with neurovirulent SIVmac R71/17E were compared to pre-inoculation records from the same monkeys. Seven of nine monkeys developed simian AIDS within 4 months of inoculation and were euthanized. Two monkeys remained free of AIDS-related clinical illness for over 18 months following inoculation. Six of the seven monkeys with rapidly progressing disease showed post-inoculation latency increases ( > or = 2 s.d. of control) in at least one cortical MEP. Increases in cortical MEP latency ranged from 21-97% in different monkeys. All seven rapidly progressing animals showed post-inoculation increases in at least one spinal cord MEP latency. Maximum spinal cord MEP latency increases ranged from 22-147%. Increases in central conduction time (CCT) ranged up to 204% and exceeded two standard deviations of control in four monkeys. Neither of the two monkeys with slowly progressing disease showed significant increases in either cortical or spinal cord MEP latency or CCT. Only the monkeys with rapidly progressing disease exhibited classic AIDS-related neuropathology, although there was no consistent relationship between the severity of neuropathology and the extent of MEP abnormalities. In conclusion, our results demonstrate clear deficits in the functional integrity of both central and peripheral motor system structures associated with SIV infection and further support the use of SIV-infected rhesus macaques as a model of neuro-AIDS.
General and cardiac toxicity of doxorubicin-loaded gelatin nanoparticles.

General and cardiac toxicity of doxorubicin loaded gelatin nanoparticles cross-linked by glutaraldheyde were investigated in healthy rats. The rats were treated with free doxorubicin (DXR), unloaded nanoparticles (UNp), physical mixture of doxorubicin and unloaded nanoparticles (DRX/UNp), and DXR-loaded nanoparticles (DXR-Np). Each group of animals received the same dose of DXR (3 mg/kg) via i.p. once a week. Both electrocardiogram (ECG) parameters and body weight were measured 24 h before each administration. Rats treated with UNp behaved as controls. DXR/UNp provoked the same toxic effects as free DXR. On the contrary, DXR-Np resulted more toxic since significant variations of both the body weight and the ECG parameters were observed during the first week of treatment. In addition, the rats treated with DXR-Np died between the 3rd and the 5th day after the 2nd administration. These results demonstrate that, in these experimental conditions, the couplage of DXR to nanoparticles enhanced the cardiotoxicity of the drug. Since DXR was linked to the protein matrix of nanoparticles via glutaraldehyde, the high toxicity of DXR-loaded nanoparticles could be due to the covalent binding of the drug to the carrier.
Reasons for ERP Acquisition

Numerous reasons for Enterprise Resource Planning (ERP) system acquisitions in organizations have been proposed in the prior research. In this paper these different reasons for ERP system acquisitions are synthesized and categorized into technological and business reasons. Further, the prevalence of the different reasons is explored with an empirical data concerning the ERP acquisition in 41 Finnish companies.
Common Variable Learning and Invariant Representation Learning using Siamese Neural Networks

We consider the statistical problem of learning common source of variability in data which are synchronously captured by multiple sensors, and demonstrate that Siamese neural networks can be naturally applied to this problem. This approach is useful in particular in exploratory, data-driven applications, where neither a model nor label information is available. In recent years, many researchers have successfully applied Siamese neural networks to obtain an embedding of data which corresponds to a "semantic similarity". We present an interpretation of this "semantic similarity" as learning of equivalence classes. We discuss properties of the embedding obtained by Siamese networks and provide empirical results that demonstrate the ability of Siamese networks to learn common variability.
Design, Analysis and Dynamic Phenomena of MEMS Capacitive Power Harvester

Unwanted vibrations are all around us in our daily life. These vibrations can effectively be converted into electrical power through capacitive device. Even though the amount of power generated is small (μW), it is still sufficient to drive certain devices, such as devices in the field of Micro Electro Mechanical System (MEMS). We call these functional devices “self-powered devices”. This dissertation describes design, modeling, analysis, dynamic simulation and experimental testing of MEMS variable capacitors which are used for power harvesting based on external vibration. More specifically, it includes the electrostatic force and the forces provided by the stopper designed to prevent direct impact between capacitive plates. To more accurately reflect the status of power harvesting, rocking instability is discussed as well. However, the onset of rocking instability leads to more complicated dynamic phenomena. This dissertation not only introduces equation theory derivation and dynamic behaviors of the MEMS capacitive harvester, but also presents a comparison of power harvesting at broad frequencies and different amplitudes. These conclusions are helpful for the design of high efficiency “self-powered” MEMS capacitive power harvester.
Euclidean Upgrade from a Minimal Number of Segments

In this paper, we propose an algebraic approach to upgrade a projective reconstruction to a Euclidean one, and aim at computing the rectifying homog- raphy from a minimal number of 9 segments of known length. Constraints are derived from these segments which yield a set of polynomial equations that we solve by means of Grobner bases. We explain how a solver for such a system of equations can be constructed from simplified template data. Moreover, we present experiments that demonstrate that the given problem can be solved in this way.
Thermal Performance Enhancement of Phase Change Materials (PCMs) by Using Metal Foams

An investigation of thermal conductivity enhancement, melting and solidification processes of Phase Change Materials (PCMs) by using metal foams has been carried out. Two models have been used in the experiments, model I for measuring the effective thermal conductivity of metal foam embedded in paraffin wax, and model II used as a small scale thermal energy storage device with and without metal foam for investigating melting and solidification processes of the PCM under different cooling conditions (natural and forced convection). The theoretical investigation involves analytical solution of two models, the semi-infinite medium for calculating the thermal conductivity, and the thermal energy storage system TESS has been analyzed including several assumptions for determining the convective heat transfer coefficient and the factors that controlling forced convection and solidification of the PCM. The experimental results show that the thermal conductivity of wax with 10 PPI metal foam increased by (37-39) times that of pure wax. Effects of pore density (10 and 40 PPI), metal foam, and mass flow rate on solidification process have been studied and the effects of pore density and metal foam on the melting process have also been investigated. The present experimental results have been compared with the available previous studies and gave a good agreement.
A Dynamic Circuit-Based Ferromagnetic Model

The development of a new dynamic circuit-based ferromagnetic model is described. The investigation of the behavior of a 24-gauge M19 silicon steel led to the conclusion that, for this material, a model that has static parameters is unable to accurately reproduce the behavior of the actual material over a large range of input frequencies and excitation levels without resorting to retuning the parameters of the model. This paper proposes two new mechanisms that dynamically adjust the parameters of the model. The provided results clearly show the effectiveness of these mechanisms.
A synthetic anti‐inflammatory sterol improves insulin sensitivity in insulin‐resistant obese impaired glucose tolerance subjects

To study the activity of HE3286 (17α‐ethynylandrost‐5‐ene‐3β,7β,17β‐triol), an anti‐inflammatory sterol that is active in models of obesity‐induced inflammation and insulin resistance in high body mass index (BMI) subjects with impaired glucose tolerance (IGT).
Occurrence of Potentially Pathogenic Bacterial-Endosymbionts in Acanthamoeba Spp.

Background: Acanthamoeba- bacteria interactions enable pathogenic bacteria to tolerate harsh conditions and lead to transmission to the susceptible host. The present study was aimed to address the presence of bacterial endosymbionts of Acanthamoeba isolated from recreational water sources of Tehran, Iran. To the best of our knowledge this is the first study regarding occurrence of bacteria in environmental Acanthamoeba spp. in Iran. Methods: A total of 75 samples of recreational water sources were collected. Samples were cultured on non- nutrient agar 1.5% plates. Positive Acanthamoeba spp. were axenically grown. DNA extraction and PCR reaction was performed using JDP1-2 primers. All positive samples of Acanthamoeba were examined for the presence of endosymbionts using staining and molecular methods. The PCR products were then sequenced in order to determine the genotypes of Acanthamoeba and bacteria genera. Results: Out of 75 samples, 16 (21.3%) plates were positive for Acanthamoeba according to the morphological criteria. Molecular analysis revealed that Acanthamoeba belonged to T4 and T5 genotypes. Five isolates (35.7%) were positive for bacterial endosymbionts using staining method and PCR test. Sequencing of PCR products confirmed the presence of Pseudomonas aeruginosa and Agrobacterium tumefasiens. Conclusion: The presence of Acanthamoeba bearing pathogenic endosymbionts in water sources leads us to public health issues including improved sanitation and decontamination measures in recreational water sources in order to prevent amoebae-related infection. To the best of our knowledge this is the first report regarding the isolation of A. tumefasiens from Acanthamoeba in Iran and worldwide.
SWORD: A Developer Toolkit for Web Service Composition

The formidable problem of automatic or semi-automatic composition of existing Web services is the subject of much current attention. We address a particular subset of this problem with SWORD, a set of tools for the composition of a class of web services including ``information-providing'' services. In SWORD, a service is represented by a rule that expresses that given certain inputs, the service is capable of producing particular outputs. A rule-based expert system is then used to automatically determine whether a desired composite service can be realized using existing services. If so, this derivation is used to construct a plan that when executed instantiates the composite service. As our working prototype and examples demonstrate, SWORD does not require (but could benefit from) wider deployment of emerging service-description standards such as WSDL, SOAP, RDF and DAML. We also distinguish SWORD from some other plausible existing approaches, especially information integration. We show that although SWORD's expressive capabilities are weaker, the abstractions it exposes capture more appropriately the limited kinds of queries supported by typical Web services and thus result in simplicity and efficiency. [Word Count: 7950 words]
Efficient Management and Fast Handovers in Software Defined Wireless Networks Using UAVs

Compared to traditional networking, SDN has better controllability and visibility for network components, which enable better management by using the common controller. In this article, the standard architecture of SDN is enhanced to utilize UAVs as on-demand forwarding switches. The proposed approach can achieve efficient management and fast handovers by decreasing the handover latency, E2E delay, and signaling overheads. The illustrated scenarios will help in understanding the impact of existing handover approaches in the next generation wireless networks, especially the upcoming 5G, which includes small cells, UAVs, UEs, and so on. The simulation study shows that scenarios with both UAVs and small cells perform better than scenarios with only small cells. The results in this article show that the proposed SDNbased handover scenarios perform better than the existing 4G-LTE handover for UAVs.
Future Processing , Research Lab ALGORITHM FOR PRECISE FRONTAL FACE DETECTION

The paper presents an algorithm for frontal face detection. At first a set of face candidates is selected based on ellipse detection with the Hough transform. Subsequently, every candidate is verified and for positive verification the detection precision is improved, which is particularly important for face recognition purposes. Results of conducted experiments, which are discussed in the paper, confirm high speed and effectiveness of the algorithm.
Stroke Prevention in Atrial Fibrillation: Latest Clinical Trials and Guidelines

Atrial Fibrillation (AF) is the most common sustained arrhythmia and 1/6 strokes is attributed to AF. The cornerstone of treatment remains maintaining sinus rhythm or appropriate ventricular rate control in addition to prevention of stroke. Oral anticoagulation therapy (OAC) with vitamin K antagonists (VKAs) has been the gold standard for almost 50 years and a significant reduction in the risk of stroke in patients with AF has been demonstrated. Nonetheless, only 50% of patients with guideline recommendations for OAC treatment actually receive VKAs and half of these will discontinue therapy within 3 to 5 years with only another half achieving therapeutic ranges more than 50% of the time. The aforementioned limitations in addition with frequent blood monitoring have prompted the development of a series of new OAC therapies. The present review focuses on the current pharmacological management for stroke prevention in patients with AF based on current and emerging evidence.
Three-axis NC cutter path generation for subdivision surface

In this paper we propose methodologies and algorithms of NC cutter path generation for subdivision surfaces. We select Loop surface as the subdivision surface. A path plan including rough cut and finish-cut is developed based on LoD (level of detail) property of the subdivision surface. We generate a coarse mesh that covers the limit surface to implement rough cut. For finish-cut we use ball-end mills and offset cutter contact positions to generate cutter location. In these two steps we use a Z-map model and a collision detection and correction method is presented for the interference-free of these two steps. We implement our methods and present machining results. All of these two kinds of cutter paths are computed rapidly and automatically.
Expanded Polyglutamine-containing N-terminal Huntingtin Fragments Are Entirely Degraded by Mammalian Proteasomes*

Background: Huntington disease is caused by an expanded polyglutamine repeat within the protein huntingtin. Results: Proteasomal degradation of mutant huntingtin fragments is devoid of polyglutamine peptides as partial cleavage products. Conclusion: Mammalian proteasomes are capable of entirely degrading expanded polyglutamine sequences. Significance: Accelerating the mutant huntingtin degradation by the proteasomal pathway obviates toxic species and represents a beneficial therapeutic strategy. Huntington disease is a neurodegenerative disorder caused by an expanded polyglutamine (polyQ) repeat within the protein huntingtin (Htt). N-terminal fragments of the mutant Htt (mHtt) proteins containing the polyQ repeat are aggregation-prone and form intracellular inclusion bodies. Improving the clearance of mHtt fragments by intracellular degradation pathways is relevant to obviate toxic mHtt species and subsequent neurodegeneration. Because the proteasomal degradation pathway has been the subject of controversy regarding the processing of expanded polyQ repeats, we examined whether the proteasome can efficiently degrade Htt-exon1 with an expanded polyQ stretch both in neuronal cells and in vitro. Upon targeting mHtt-exon1 to the proteasome, rapid and complete clearance of mHtt-exon1 was observed. Proteasomal degradation of mHtt-exon1 was devoid of polyQ peptides as partial cleavage products by incomplete proteolysis, indicating that mammalian proteasomes are capable of efficiently degrading expanded polyQ sequences without an inhibitory effect on the proteasomal activity.