Miracle-dz/UniFAR-FTUs huggingface dataset:
Orthotopic Xenograft Model of Cervical Cancer for Studying Microenvironmental Effects on Metastasis Formation and Response to Drug Treatment

Cancers arising in the uterine cervix are usually squamous cell carcinomas that develop from preneoplastic lesions. They invade locally, and then typically metastasize to the regional lymph nodes and eventually to distant sites. Orthotopically grown xenografts are technically challenging to perform, but recapitulate the clinical situation to a greater extent than xenografts grown at subcutaneous or intramuscular sites. Thus, orthotopic xenografts develop lymphovascular invasion and metastasize to the para‐aortic lymphatic chain in a pattern similar to that seen in patients. The extent of (lymph node) metastases is particularly apparent when the implanted tumor cells are transfected to express a fluorescent marker, such as DsRed, which allows the exposed retroperitoneum to be examined by fluorescence microscopy. Described in this unit is a surgical technique for orthotopic implantation and the use of this model for investigating the effects of novel agents as inhibitors of tumor growth and metastasis. Curr. Protoc. Pharmacol. 53:14.19. 1‐14.19. 11. © 2011 by John Wiley & Sons, Inc.
On Consistency and Sparsity for Principal Components Analysis in High Dimensions

Principal components analysis (PCA) is a classic method for the reduction of dimensionality of data in the form of n observations (or cases) of a vector with p variables. Contemporary datasets often have p comparable with or even much larger than n. Our main assertions, in such settings, are (a) that some initial reduction in dimensionality is desirable before applying any PCA-type search for principal modes, and (b) the initial reduction in dimensionality is best achieved by working in a basis in which the signals have a sparse representation. We describe a simple asymptotic model in which the estimate of the leading principal component vector via standard PCA is consistent if and only if p(n)/n → 0. We provide a simple algorithm for selecting a subset of coordinates with largest sample variances, and show that if PCA is done on the selected subset, then consistency is recovered, even if p(n) ≫ n.
C Block Location BLocation AGardens Point RoadCaptain Cook Bridge ADV Location AGardens Point Road Stairwells ADV Location B Flow constriction 2 20 Gardens Point Road A D V Water

In urbanized areas, flood flows constitute a hazard to populations and infrastructure, as illustrated during major floods in 2011. During the 2011 Brisbane River flood, some turbulent velocity data were collected using acoustic Doppler velocimetry in an inundated street. The field deployment showed some unusual features of flood flow in the urban environment. That is, the water elevations and velocities fluctuated with distinctive periods between 50 and 100 s linked with some local topographic effects. The instantaneous velocity data were analyzed using a triple decomposition. The velocity fluctuations included a large energy component in the slow fluctuation range, whereas the turbulent motion components were much smaller. The suspended sediment data showed some significant longitudinal flux. Altogether, the results highlighted that the triple decomposition approach originally developed for periodic flows is well-suited to complicated flows in an inundated urban environment. DOI: 10.1061/(ASCE)HY.1943-7900.0000666. © 2013 American Society of Civil Engineers. CE Database subject headings: Flood plains; Urban areas; Turbulence; Measurement; Suspended sediment; Rivers and streams; Australia. Author keywords: Flood plain; Urban environment; Turbulence measurements; Triple decomposition; Suspended sediment concentration SSC; Water body resonance; Brisbane River.
pH Sensing and Low-Frequency Noise Characteristics of Low Temperature (400 °C) p-Channel SOI Schottky ISFETs

Planar platinum silicide (PtSi) Schottky barrier (SB) p-channel silicon-on-insulator (SOI) ion-sensitive field effect transistors (ISFETs) have been fabricated at low temperature (400 °C) for biosensor applications. The use of PtSi not only eliminates the ion implantation process and associated high temperature annealing, it also simplifies the process complexity. Both dc and low frequency noise have been characterized. It is found that the SB p-channel SOI ISFET shows a high sensitivity of 55 mV/pH and a resolution limit of 0.0136% of a pH shift with 1 Hz bandwidth. All these suggest that the low temperature PtSi SB SOI ISFET is one of the promising candidates for biochemical detection.
A wide tuning range QCCO based on CMOS active inductors

In this paper, a quadrature current-controlled oscillator (QCCO) based on active inductors has been implemented in SMIC 0.13 um 1P8M RF CMOS process. Simulation results show that this circuit can achieve a very wide tuning range of 85.7% from 400 MHz to 1 GHz and the phase noise is from -97.3 dBc/Hz@1MHz to -91.5 dBc/Hz@1MHz between the two ends of the tuning range. The QCCO core only draws approximately 3.5 mA current from a 1.2 V power supply. Due to the absence of conventional spiral inductors, this circuit occupies a much smaller areas.
Isolation and expression analysis of three zebrafish angiopoietin genes

The Tie1 and Tie2 receptor tyrosine kinases and the Tie2 ligands, the angiopoietins, play critical roles in vertebrate vascular embryogenesis, helping to mediate the interaction between endothelial cells and the pericytes or vascular smooth muscle cells that envelop and support them. We have obtained full‐length cDNA sequences for zebrafish orthologs of angiopoietin‐1 (ang1), angiopoietin‐2 (ang2), and angiopoietin‐like‐3 (angptl3). Ang1 is expressed in head ventral mesenchyme, in the ventromedial region of somites, in mesenchyme surrounding trunk axial vessels, and in the hypochord, a transient embryonic structure of endodermal origin that has been implicated in dorsal aorta assembly in both zebrafish and Xenopus. Ang2 is expressed in head and anterior trunk ventral mesenchyme and the developing pronephric glomeruli. Angptl3 is expressed in the yolk syncytial layer. © 2001 Wiley‐Liss, Inc.
An Exploration of the Relationships Between Multiple Mini-Interview Scores and Personality Traits

Objective. To explore the relationship between pharmacy students’ social and behavioral competencies assessed using multiple mini-interviews (MMIs) and their personality traits. Methods. A retrospective study was conducted using data from two Doctor of Pharmacy (PharmD) cohorts. Students’ self-reported scores from an externally validated tool completed during their first professional year that assessed five personality traits (openness to experiences, conscientiousness, extraversion, agreeableness, and emotionality) were collected. Students’ scores on empathy, integrity, adaptability, critical thinking, and collaboration were collected during MMIs conducted during the admissions process. Analysis of variance was used to test the homogeneity of the sample, and correlation analyses were used to determine the strength of relationships between variables. Results. When examining for associations between students’ personality traits and their social and behavioral competencies measured during the MMIs, we found a few significant but very weak correlations with extraversion. Conclusion. Our results revealed weak to negligible correlations between scores on competencies measured during the MMIs and personality traits, potentially because the assessments measured different constructs.
Multiple Provisioning Domain Architecture

This document is a product of the work of the Multiple Interfaces Architecture Design team. It outlines a solution framework for some of the issues experienced by nodes that can be attached to multiple networks simultaneously. The framework defines the concept of a Provisioning Domain (PvD), which is a consistent set of network configuration information. PvD-aware nodes learn PvD-specific information from the networks they are attached to and/or other sources. PvDs are used to enable separation and configuration consistency in the presence of multiple concurrent connections.
Plasma free fatty acid concentrations in obesity.

ADIPOSE tissue, previously thought to be metabolically inert, has now been recognized as one of the most active tissues in the body,1 being a major site of insulin activity and carbohydrate-lipid interaction. As a result, there has been a renewed interest in the problems of obesity, with a re-examination of lipid metabolism for possible differences between obese and normal subjects. The purpose of the present study is to analyze one parameter of lipid metabolism in obesity — namely, the concentration of plasma free fatty acid (FFA = nonesterified fatty acid = NEFA). The primary source from which lipid is mobilized .
Balloon-assisted coil embolization of intracranial aneurysms: incidence, complications, and angiography results.

OBJECT The aim of this study was to assess the incidence, indications, complications, and angiography results associated with balloon-assisted coil embolization (BACE) of intracranial aneurysms and to compare these factors with those for conventional coil embolization (CE). METHODS Between 1995 and 2005, 827 intracranial aneurysms in 757 consecutive patients were packed with coils. Balloon-assisted coil embolization was used in 8.6% (71 of 827) of the coil insertion procedures and was more frequently used in large aneurysms, unruptured lesions, and those located on the vertebrobasilar system and carotid artery. Procedure-related complications leading to death or dependency were significantly higher in BACEs (14.1%) compared with those in CEs (3%). Packing densities and the results of 6-month follow-up angiography studies did not differ significantly between the two types of treatments. There was a strong trend for a higher retreatment rate in the aneurysms treated with BACE. CONCLUSIONS Balloon-assisted coil embolization of intracranial aneurysms is associated with a high complication rate and should only be used if conventional CE of these lesions is impossible or has failed and if anticipated surgical risks are too high. The BACE procedure does not improve the occlusion rates of the aneurysms on follow-up evaluation.
Mineralogy and geochemistry of feed coals and combustion residues of the Kangal power plant (Sivas, Turkey)

This study focuses on mineralogical and geochemical compositions of feed coal (FC) and combustion residues, namely fly ash (FA) and bottom ash (BA) samples, obtained from the Kangal coal-fired power plant in central Turkey. The X-ray powder diffraction data indicate that carbonate and clay minerals are dominant phases in the FC samples. In the FA samples, quartz, hematite, anhydrite, lime, and feldspar are generally dominant and abundant phases, whereas calcite, ettringite, and portlandite are generally more abundant in the BA samples. The elements Mo, Cs, and U are significantly enriched in the studied FC, FA, and BA samples. The statistical analysis and SEM-EDX data show that Ca, Ti, and the vast majority of trace elements are inorganically affiliated, and only Tl and U have prob-able organic affinity in the FC. In addition, the redox conditions in the paleomires presumably resulting in Mo and U enrichment in FC, whereas their enrichment in FA and BA is most likely related to retention by CaO and Ca-sulfate. The Cs enrichment in FA is due to retention by glass. The elements in the FA and BA are distinguished into four groups according to their volatility during combustion. The elements As, Mo, Cd, Tl, and U (Group I) are the most volatile elements during combustion and condensation in the FA. The elements Li, Zn, Ga, Rb, Nb, Cs, Ba, La, and Pb (Group IV) did not become more volatile or less volatile during combustion and are located in BA. Nevertheless, Zn and Pb in the BA seem to be related to the presence of unaffected pyrite and sphalerite, and are due to low combustion efficiency of the boiler during the sampling period. Overall, enriched elements and minerals in FA and BA suggest that their disposal should be undertaken with caution.
Cyber-attack detection based on controlled invariant sets

This paper explores a new method for detecting cyber-attacks on a controller. Specifically, the proposed detector is based on invariant sets in order to determine whether an attacker has hijacked the controller and perpetrated a cyber-attack. One particularity of this detection method is that few information about the controller is required. Thus, the detector becomes useful for a large range of control laws and its vulnerability can be reduced by limiting its accessibility. Finally, a simple but significant example is presented in order to show the benefits and the flaws of the proposed methodology.
Moral distress among critical care clinicians: Protective factors and consequences on clinicians’ well-being and quality of care

5 INTRODUCTION . 7 CHAPTER 1. Psychological well-being and moral distress among critical care clinicians . 9 1. Psychological well-being of critical care clinicians . 9 2. Definition of moral distress . 12 3. Measures of moral distress . 15 4. The moral residue and the crescendo effect model . 17 5. Contributing factors and effects of moral distress.18 CHAPTER 2. Systematic review of moral distress and related constructs . 22 1. Abstract . 22 2. Introduction . 23 3. Methods . 24 4. Results . 26 5. Discussion . 35 CHAPTER 3. Study 1. Validation of the Italian Moral Distress Scale-Revised (MDS-R) among critical care clinicians . 40 1. Abstract . 40 2. Introduction . 41 3. Methods . 43 4. Results . 47 5. Discussion . 52 CHAPTER 4. Study 2. Value congruence and depressive symptoms in critical care clinicians: the mediating effect of moral distress.56 1. Abstract . 56 2. Introduction . 57 3. Methods . 60 4. Results . 64 5. Discussion . 67 CHAPTER 5. Study 3. Moral distress and family satisfaction with the quality of care: a preliminary study . 70 1. Abstract . 70 2. Introduction . 71
Miniaturisation of Defected Ground Plane Using Complementary Metallodielectric Electromagnetic Band Gap Structures

The concept of Complementary Electromagnetic Band-Gap Structures employing dipole elements as conductors and apertures is employed for the miniaturisation of Defected Ground Plane (DGS) structures. Conductor and aperture dipoles are placed in close proximity with a rotation of 90 o between them, in order to produce maximum coupling, which proves to yield maximum miniaturisation in the order of 2.3:1. An efficient numerical method based in Method of Moments (MoM) is used to simulate and predict the surface response of the complementary array. Dispersion curves have been produced to study the modes supported by the array. Simulated and measured surface wave responses are presented for finite size DGSs excited by a transmission line. A substantial decrease of the stop band frequency is observed, as the width of the conducting elements is increased. the incident electric field in this case. The apertures are rotated 90 0 with respect to the conductors, so that both elements will be polarized with the electric field. Floquet modal analysis has been employed for the rigorous full-wave simulation of the unit cell, in the absence of any circuitry. Two coupled Integral Equations are derived upon application of electromagnetic boundary conditions at each interface,. A Magnetic Field Integral Equation (MFIE) is formed for the fields within the apertures and an Electric Field Integral Equation (EFIE) for the currents in the conductors (3). These can be brought into matrix form with application of the Method of Moments (4,5) for the unknown fields and currents. The dispersion characterisation is based on the existence of non-trivial solution when the incidence is assumed zero. In order for the set of homogeneous linear equation to have non trivial solutions, the determinant of the matrix (Z) must be zero (characteristic determinant). By varying the β from zero to the boundary of the irreducible Brillouin zone, all the corresponding characteristic determinants are ploted out for each β. From the plot all the true set minima correspond to each individual propagation mode.
To sleep, or not to sleep – that is the question, for polysomnography

As the English dramatist Thomas Dekker wrote, “Sleep is that golden chain that ties health and our bodies together”. One of the most frequently sleep-related disorders (SRD) is obstructive sleep apnoea syndrome (OSAS). OSAS is a relatively “young” disease and at the same time, one of the most important respiratory conditions discovered in the last 50 years due to its incidence, prevalence, health-related impact on the patient’s life and economic burden [1]. Have we reached the point where respiratory polygraphy can replace polysomnography in the assessment of OSAS? http://ow.ly/UxCU30bNopq
Robust Extended Kalman Filtering in Hybrid Positioning Applications

The Kalman filter and its extensions has been widely studied and applied in positioning, in part because its low computational complexity is well suited to small mobile devices. While these filters are accurate for problems with small nonlinearities and nearly Gaussian noise statistics, they can perform very badly when these conditions do not prevail. In hybrid positioning, large nonlinearities can be caused by the geometry and large outliers (blunder measurements) can arise due to multipath and non line-of-sight signals. It is therefore of interest to find ways to make positioning algorithms based on Kalman-type filters more robust. In this paper two methods to robustify the Kalman filter are presented. In the first method the variances of the measurements are scaled according to weights that are calculated for each innovation, thus giving less influence to measurements that are regarded as blunder. The second method is a Bayesian filter that approximates the density of the innovation with a non-Gaussian density. Weighting functions and innovation densities are chosen using Hubers min-max approach for the epsilon contaminated normal neighborhood, the p-point family, and a heuristic approach. Six robust extended Kalman filters together with the classical extended Kalman filter (EKF) and the second order extended Kalman filter (EKF2) are tested in numerical simulations. The results show that the proposed methods outperform EKF and EKF2 in cases where there is blunder measurement or considerable linearization errors present.
Intraseasonal modulation of spring‐strong wind events associated with convection in northeastern Argentina

The relationship between intraseasonal variability (IS; 10–90 days) and days which registered convection‐associated strong surface wind events (CSSWE) over northeastern Argentina (NEA) was studied. The climatological behaviour of these strong wind events showed a higher duration and occurrence in austral spring. CSSWE were categorized as a function of the wet and dry phases of the spring‐season intraseasonal (spring‐SIS) index, which describes the activity of the leading pattern of IS‐filtered outgoing longwave radiation (IS‐OLR) during that season in eastern South America. A modulation of the IS variability over localized and mesoscale phenomena as the CSSWE was found, showing significant peaks of wind variability in that timescale, and especially the submonthly timescale. The CSSWE were categorized according to the phases of the spring‐SIS pattern and most of them occurred before or during a wet phase, especially for the longer CSSWE. Moreover, the detection of CSSWE days during and before a dry phase was scarce. Rossby wave trains were observed to organize the circulation on intraseasonal timescales that configure regional cyclonic anomalies in such way that favours the development of CSSWE, promoting mid‐level ascents over NEA and northerly advection of humidity to the region. Together with the composites of IS‐OLR anomalies and the spectra of wind velocity, they support the fact that the higher‐frequency IS variability is the primary influence for the development of CSSWE.
An efficient multicasting method without a base station

Ad-hoc networks, which do not require a base station such as an access point, have a hidden node problem because nodes communicating in the same time cannot know each other's communication status. On the other hand, in the wireless infrastructure network the access point manages the communication with the node using RTS (Request to Send) and CTS (Clear to Send). However, in the broadcasting, we cannot use RTS/CTS method because the number of target nodes is not 1 but more than 2. In this paper, we propose a broadcasting method based on RTS/CTS to avoid this problem. The sender node selects the target node. And they communicate with each other. Neighboring nodes can listen to these packets. Then sender node can broadcast its information to multi nodes. We use wireless nodes specified by IEEE 802.15. 4 which is the physical layer's specification. And our experimental results show the effective transmissions.
Target Evaluation and Correlation Method (TECM) as an Assessment Approach to Global Earth Observation System of Systems (GEOSS)

The Global Earth Observation System of Systems (GEOSS) is a ten-year-long Implementation Plan, which commenced in 2005 as a group effort by numerous participating countries and organizations to build a large-scale network to effectively monitor and respond to the increasingly complex web of global environmental and socio-economic issues. This paper proposes the Target Evaluation and Correlation Method (TECM) as an assessment approach to GEOSS with its 241 Targets across the nine "Societal Benefit Areas," along with a method to identify Target Correlation Levels (TCL). Applying TECM allows concluding whether the chosen targets within the GEOSS fall into the domain of System of Systems (SoS), while using TCLs delineates the extent of inclusion for these targets in the form of a system. Furthermore, this research investigates the possible ways of raising the correlation levels of the targets for the cases in which TCLs are low.
Abusing Android permissions: A security perspective

The drastic increase of mobile apps and its direct impact on the security of user's device and data cannot be neglected. Such data nowadays is related to (almost) all life aspects. Even with the growing awareness to develop more secure apps, but still existed mobile apps found on app stores cannot be considered fully benign. This paper is giving a special attention to Android permissions and how they can be abused by security attacks. Most rated education apps have been selected to perform deep permissions analysis and categorization in terms of protection level and mostly abused ones. Moreover, the apps have been examined to check if they support advertisements or not. The results reveal that 80.3% of the apps are requesting permissions more than what they need and actually used. Consequently, such over-privileged apps would be exposed to serious malicious behaviors. The paper discusses possible solutions to overcome this issue and suggests possible ways to select the required permissions throughout the app development process.