Miracle-dz/UniFAR-FTUs huggingface dataset:
Conversion and Coding Practices for HDR/WCG ICTCP 4:2:0 Video

ICTCP is a colour difference signal representation recently standardized in Rec. ITU-R BT.2100. One design criteria of ICTCP for HDR/WCG imagery is to address issues in Non-Constant Luminance (NCL) Y'CbCr with HDR/WCG signals. In this paper, the superior performance of ICTCP in preserving constant luminance over the NCL Y'CbCr is analyzed in detail. The fundamental limitations of Y'CbCr luma adjustment algorithm which aims at fixing chroma subsampling artifact of Y'CbCr is discussed as well. This paper also provides guidance on signaling of ICTCP and feasible encoder settings with HEVC Main 10 codec. Experimental results suggest that for HDR content with real BT. 2100 (BT. 2020) colour gamut, to perform chroma subsampling and compression in ICTCP have significant value.
Vancomycin Resistance, esp, and Strain Relatedness: a 1-Year Study of Enterococcal Bacteremia

ABSTRACT The prevalence of esp, a gene associated with infection-derived and outbreak strains, in enterococcal blood isolates from 2002 was determined. Fifty-five of 137 (40.1%) Enterococcus faecalis isolates, 30 of 58 (51.7%) E. faecium isolates, 1 of 1 E. raffinosus isolate, 0 of 4 E. gallinarum isolates, and 0 of 1 E. casseliflavus isolate were positive. esp wasn't associated with vancomycin resistance (VR) or clinical service. VR E. faecium isolates were less genetically diverse than vancomycin-susceptible strains. A large cluster of VR isolates, belonging to esp-positive E. faecium, was revealed. These data support the hypothesis that esp and VR may contribute to dissemination of particular clones.
Long-term bond strengths to dentin treated with different re-wetting solutions.

PURPOSE To evaluate the microtensile bond strengths (microTBS) of two etch-and-rinse one-bottle adhesive systems to air-dried dentin re-wet with different agents. METHODS 48 bovine teeth were ground flat to 600-grit and were assigned for treatment with either Single Bond or One-Step adhesives. Each group had three subgroups of re-wetting agents: water, Gluma Desensitizer and Aqua-Prep F. The teeth were acid-etched, air-dried for 5 seconds and re-wet with water, Gluma Desensitizer or Aqua-Prep F for 30 seconds and blot dried. Control specimens were prepared using a moist bonding technique. The adhesives were applied and the teeth were restored with Filtek Z250 or Renew composite. After 24 hours in distilled water at 37 degrees C, the teeth were sectioned into 0.7 mm-thick slabs, trimmed, and immediately tested for microTBS or stored for 6 months or 1 year prior to testing. Fracture sites were examined under scanning electron microscope (SEM). Data were evaluated by one- and three-way ANOVA, and Fisher's PLSD test (P<0.05). RESULTS Except for Aqua-Prep F, the microTBS in the control, water and Gluma Desensitizer subgroups did not change significantly after 1-year for both Single Bond and One-Step groups. SEM analysis showed no specific pattern of fracture in the Single Bond specimens. One-Step had the majority of the fractures at the interface at baseline, and becoming a mixture of fractures at the interface and within the adhesive resin after 1 year.
Recent Progress with the Engine Health Diagnostics Using Radar System

[Abstract] Engine health monitoring is an important aspect of aircraft design, essential for safety and necessary for good maintenance practice. This paper describes an engine health monitoring system which uses radar to capture data from an air intake or the inside of an engine. The Engine Health Diagnostics Using Radar System has been successfully tested to identify Foreign Object Debris. It has also been tested on aircraft jet engines to collect data from engine fan blades for High Cycle Fatigue, vibration and blade displacement.
Anti-tumor activity of motesanib in a medullary thyroid cancer model

Background: Medullary thyroid cancer (MTC) is frequently associated with mutations in the tyrosine kinase Ret and with increased expression of vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2). Motesanib is an investigational, orally administered small molecule antagonist of VEGFR1, 2, and 3; platelet-derived growth factor receptor (PDGFR); Kit; and possibly Ret. Aim: The aim of this study was to investigate the effects of motesanib on wild-type and mutant Ret activity in vitro and on tumor xenograft growth in a mouse model of MTC. Methods/Results: In cellular phosphorylation assays, motesanib inhibited the activity of wild-type Ret (IC50=66 nM), while it had limited activity against mutant Ret C634W (IC50=1100 nM) or Ret M918T (IC50>2500 nM). In vivo, motesanib significantly inhibited the growth of TT tumor cell xenografts (expressing Ret C634W) and significantly reduced tumor blood vessel area and tumor cell proliferation, compared with control. Treatment with motesanib resulted in substantial inhibition of Ret tyrosine phosphorylation in TT xenografts and, at comparable doses, in equivalent inhibition of VEGFR2 phosphorylation in both TT xenografts and in mouse lung tissue. Conclusions: The results of this study demonstrate that motesanib inhibited thyroid tumor xenograft growth predominantly through inhibition of angiogenesis and possibly via a direct inhibition of VEGFR2 and Ret expressed on tumor cells. These data suggest that targeting angiogenesis pathways and specifically the VEGF pathway may represent a novel therapeutic approach in the treatment of MTC.
Genomic analyses of the cup-shaped cotyledon 1 network

El desarrollo de la flor ha sido un importante campo de investigacion por muchos anos y el analisis extensivo de interacciones geneticas resulto en un marco de referencia que permitio entender como se produce la especificacion de los organos florales. Recientemente, la introduccion de tecnologias de nivel genomico permitio confrimar y expandir los modelos existentes sobre el establecimiento de la identidad de los organos florales y otros eventos importantes que ocurren durante la formacion de la flor. A pesar de esto, hay otros aspectos del desarrollo floral para los cuales no existen modelos generales, como el caso de la formacion de los limites entre los organos de la flor. El gen CUP-SHAPED COTYLEDON1 (CUC1) Arabidopsis thaliana es un factor de transcripcion clave involucrado en la regulacion del desarrollo floral mediante el control de la formacion de estos limites o fronteras. En las plantas, la separacion correcta entre distintos tejidos es fundamental para el mantenimiento de los meristemos y para coordinar la formacion de nuevos organos. Esto ocurre a traves de todo el desarrollo de la planta, desde la separacion temprana de cotiledones en las dicotiledoneas, hasta la fromacion de limites entre ovulos durante la fase reproductiva. CUC1 reprime el crecimiento en la zona de los limites que contribuye a establecer y se propuso que lo hace afectando la division celular. A pesar de este rol crucial de CUC1, los mecanismos moleculares a traves de los cuales controla la formacion de limites no estan descriptos de manera extensiva. Aqui, la red regulatoria de CUC1 es caracterizada a nivel genomico, usando tecnologias de ultima generacion. En este trabajo, varios aspectos de la funcion de CUC1 fueron analizados por primera vez mediante la combinacion de enfoques complementarios que incluyen la transcriptomica, el perfil de union al DNA del factor de transcripcion y el analisis de interaccion entre proteinas. Los resultados obtenidos por estas tecnicas permitieron dilucidar un set de dianas transcripcionales, vias moleculares e interactores proteicos de CUC1 que ayudan a delinear los mecanismos por los cuales este factor de transcipcion del tipo NAC contribuye al establecimiento de los limites entre organos florales. Estos resultados representan un avance sustancial para la comprension de los eventos moleculares controlados por CUC1 en esta etapa fundamental del desarrollo de una planta. En este sentido, esta Tesis provee un cuerpo de trabajo fundacional que puede utilizarse para explorar la red regulatoria de CUC1 mas profundamente.
Expression of P450(arom) in Malaclemys terrapin and Chelydra serpentina: a tale of two sites.

The formation of estrogens from androgens in all vertebrates is catalyzed by the "aromatase" complex, which consists of a membrane bound P(450) enzyme, P(450) aromatase (which binds the androgen substrate and inserts an oxygen into the molecule), and a flavoprotein (NADPH-cytochrome P450 reductase). Among vertebrates, the two major sites of aromatase expression are the brain and gonads. Given the importance of estrogen in reptile sex determination, we set out to examine whether P450arom was involved in the initiation and/or stabilization of sex determination in turtles. We examined the expression of aromatase activity in the brain and gonads of two turtle species exhibiting temperature dependent sex determination (TSD), the diamondback terrapin (Malaclemys terrapin), and the common snapping turtle (Chelydra serpentina). Estradiol when applied at stage 14 of the terrapin induces expression of aromatase in the gonad of embryos incubated at male temperatures (26.5 degrees C). The level of expression is similar to that of a normal embryonic ovary. When applied at stage 22, estradiol does not induce aromatase expression in the terrapin. The xenoestrogen, nonylphenol, sex reverses terrapin embryos at 26.5 degrees C. Letrazole, a nonsteroidal aromatase inhibitor, suppresses aromatase activity in the brain at either incubation temperature. Ovotestes are produced by letrazole administration in the terrapin when incubated at 30.5 degrees C. In the snapping turtle at stage 23, gonadal and brain aromatase activity in embryos incubated at female temperatures (30.5 degrees C) is nearly half that exhibited in terrapin embryos at the same temperature. Moreover, letrazole administration suppresses aromatase expression to nearly basal levels. At male incubation temperatures (26.5 degrees ), brain aromatase expression is nearly three times higher than at female temperatures, while gonadal expression levels are nearly one third lower. However, the gonadal expression levels at male temperatures in the snapping turtle are nearly 25 times higher than that found in the terrapin. Estradiol administration elevates this level nearly three fold. These data suggest that is not merely the expression of aromatase that is important for ovarian development, but that the level of expression may be more important.
Development of Web Production Drawings Management System Based on Fingerprint Recognition Technology

Aiming at the behindhand management and ineffective supervision existing in production management and production supervision,it proposes a web production drawings management system solution based on fingerprint recognition technology.It describes the modularized system design framework integrating fingerprint recognition and drawings management system according to the production information flow,illustrates the main function and its realization of fingerprint recognition technology.The system can monitor the production information flow with the fingerprint information embedded in the production drawing.It evaluates the proposed solution by the application of the web production drawings management system.The result shows that the system can improve the production monitoring capability distinctly.
High serum IgG4 concentrations in patients with sclerosing pancreatitis.

BACKGROUND Sclerosing pancreatitis is a unique form of pancreatitis that is characterized by irregular narrowing of the main pancreatic duct, lymphoplasmacytic inflammation of the pancreas, and hypergammaglobulinemia and that responds to glucocorticoid treatment. Preliminary studies suggested that serum IgG4 concentrations are elevated in this disease but not in other diseases of the pancreas or biliary tract. METHODS We measured serum IgG4 concentrations using single radial immunodiffusion and an enzyme-linked immunosorbent assay in 20 patients with sclerosing pancreatitis, 20 age- and sex-matched normal subjects, and 154 patients with pancreatic cancer, ordinary chronic pancreatitis, primary biliary cirrhosis, primary sclerosing cholangitis, or Sjögren's syndrome. Serum concentrations of immune complexes and the IgG4 subclass of immune complexes were determined by means of an enzyme-linked immunosorbent assay with monoclonal rheumatoid factor. RESULTS The median serum IgG4 concentration in the patients with sclerosing pancreatitis was 663 mg per deciliter (5th and 95th percentiles, 136 and 1150), as compared with 51 mg per deciliter (5th and 95th percentiles, 15 and 128) in normal subjects (P<0.001). The serum IgG4 concentrations in the other groups of patients were similar to those in the normal subjects. In patients with sclerosing pancreatitis, serum concentrations of immune complexes and the IgG4 subclass of immune complexes were significantly higher before glucocorticoid therapy than after four weeks of such therapy. Glucocorticoid therapy induced clinical remissions and significantly decreased serum concentrations of IgG4, immune complexes, and the IgG4 subclass of immune complexes. CONCLUSIONS Patients with sclerosing pancreatitis have high serum IgG4 concentrations, providing a useful means of distinguishing this disorder from other diseases of the pancreas or biliary tract.
Parametric Programming Applied to Reliability Optimization Problems

In practical reliability optimization models, finding an optimal solution to the model is not the only requirement. One may also be interested in solutions that are close to optimum, or one may want to know what happens if a change is made in the model. This paper presents new reliability optimization models which can be formulated as parametric nonlinear integer programming problems. Solution methods are illustrated with examples and flow charts.
The hepatitis B virus core and e antigens elicit different Th cell subsets: antigen structure can affect Th cell phenotype

Secretion of the hepatitis B virus (HBV) e antigen (HBeAg) has been conserved throughout the evolution of hepadnaviruses. However, the function of this secreted form of the viral nucleoprotein remains enigmatic. It has been suggested that HBeAg functions as an immunomodulator. We therefore examined the possibility that the two structural forms of the viral nucleoprotein, the particulate HBV core (HBcAg) and the nonparticulate HBeAg, may preferentially elicit different T helper (Th) cell subsets. For this purpose, mice were immunized with recombinant HBcAg and HBeAg in the presence and absence of adjuvants, and the immunoglobulin G (IgG) isotype profiles of anti-HBc and anti-HBe antibodies were determined. Second, in vitro cytokine production by HBcAg- and HBeAg-primed Th cells was measured. The immunogenicity of HBcAg, in contrast to that of HBeAg, did not require the use of adjuvants. Furthermore, HBcAg elicited primarily IgG2a and IgG2b anti-HBc antibodies, with a low level of IgG3, and no IgG1 anti-HBc antibodies. In contrast, the anti-HBe antibody response was dominated by the IgG1 isotype; low levels of IgG2a or IgG2b anti-HBe antibodies and no IgG3 anti-HBe antibodies were produced. Cytokine production by HBcAg- and HBeAg-primed Th cells was consistent with the IgG isotype profiles. HBcAg-primed Th cells efficiently produced interleukin-2 (IL-2) and gamma interferon (IFN-gamma) and low levels of IL-4. Conversely, efficient IL-4 production and lesser amounts of IFN-gamma were elicited by HBeAg immunization. The results indicate that HBcAg preferentially, but not exclusively, elicits Th1-like cells and that HBeAg preferentially, but not exclusively, elicits Th0 or Th2-like cells. Because HBcAg and the HBeAg are cross-reactive in terms of Th cell recognition, these findings demonstrate that Th cells with the same specificity can develop into different Th subsets based on the structural form of the immunogen. These results may have relevance to chronic HBV infection. Circulating HBeAg may downregulate antiviral clearance mechanisms by virtue of eliciting anti-inflammatory Th2-like cytokine production. Last, the influence of antigen structure on Th cell phenotype was not absolute and could be modulated by in vivo cytokine treatment. For example, IFN-alpha treatment inhibited HBeAg-specific Th2-mediated antibody production and altered the IgG anti-HBe isotype profile toward the Th1 phenotype.
Passive regenerative snubber cell applied to isolated DCM SEPIC converter

Isolated converter such as SEPIC has a high voltage stress in the main switch due to transformer leakage inductance. To solve this issue an active or passive clamp action is necessary. The common passive solution based on a RCD snubber is simple but impractical when the value of the leakage inductance is significant. In other hands, passive regenerative solutions generally compromise the isolation, making the search for a suitable snubber a challenge. In this paper, an effective passive regenerative snubber cell for isolated DCM SEPIC converters is presented. It is intended to improve the converter efficiency by transferring the energy stored in the transformer leakage inductance to the output. Analysis is presented in detail together with a practical design procedure. To validate the proposal, simulated and experimental results are performed for a 100 W, 100 V input and 50 V output voltage converter.
A review of the phenomenology and cognitive neuropsychological origins of the Capgras syndrome

In this article the epidemiology, aetiology, neuroanatomy and neuropsychology of the Capgras syndrome (CS) are reviewed in detail. CS is characterized by the delusional belief that one or a few highly familiar people have been replaced by impostors who are physically very similar to the original/s. The patient acknowledges that the double and known person look alike, but maintains the belief that the significant person, in psychological terms, is absent.
How Much We Think of Ourselves and How Little We Think of Others: An Investigation of the Neuronal Signature of Self-Consciousness between Different Personality Traits through an Event-Related Potential Study.

BACKGROUND Previous studies have revealed that self-related tasks (items) receive more attention than non-self-related, and that they elicit event-related potential (ERP) components with larger amplitudes. Since personality has been reported as one of the biological correlates influencing these components, as well as our behavioural differences, it is important to examine how it affects our self-consciousness in relation to tasks of varied relevance and the neurological basis. METHODS A total of 33 male and female undergraduate Malaysian medical students of Universiti Sains Malaysia (USM) participated in the study. The participants were divided into two groups, Ambivert (n = 18) and Extravert (n = 15) groups, using the USM personality inventory questionnaire. In the ERP experiment, squares containing standard stimuli of any word other than self and non-self-related nouns (e.g., Bola, Gigi, Anak, etc.; in English: Ball, Teeth, Kids, etc., respectively), those containing self-related pronouns (Saya, Kami or Kita; in English: I, Us or We, respectively), and non-self-related pronouns (Dia, Anda or Mereka; in English: He/She, You or They, respectively), were shown 58%, 21% and 21% of the time, respectively, in a three-stimulus visual oddball paradigm. All words were presented in Bahasa Melayu. The participants were instructed to press 1 for self and 2 for non-self, and ignore standard stimuli. RESULTS Comparison of both N200 and P300 amplitudes for self-related and non-self-related pronouns in the Extravert group revealed significant differences at seven electrode sites, with self-related having larger amplitude at anterior electrodes and less at posterior. This was not seen in the Ambivert group. CONCLUSION The present study suggests that self-relevant pronouns are psychologically more important to extraverts than to ambiverts; hence, they have more self-awareness. This may be due to large amount of dopamine in the brains of extraverts, which is more concentrated in the frontal lobe.
Performance comparison of correlation-based receive filters in an ultrasonic Indoor Positioning System

Accurate distance estimation is a key part for certain active sensing systems as ultrasonic Indoor Positioning Systems (IPSs). In these systems, receive filters play a key role for the achievement of robust and accurate position estimations. For that reason, this paper carries out the performance comparison of different receive filters, namely matched-filter, generalized cross-correlation function, adaptive generalized cross-correlation function and mismatched-filter in an ultrasonic indoor positioning system. Simulations and real results show that by using the appropriate receive filter the mean absolute error in positioning can be reduced by a percentage of about 70%.
Multivalent binding of K99 fimbriae to the N-glycolyl-GM3 ganglioside receptor

The ganglioside N-glycolyl-GM3 binds laterally at numerous positions to K99 fimbriae, as shown by electron microscopic detection and erythrocyte-binding activity. The data demonstrate the multivalent nature of K99 fimbriae with respect to their receptor-binding sites.
Three‐dimensional radial ultrashort echo‐time imaging with T2 adapted sampling

The application of 3D radial sampling of the free‐induction decay to proton ultrashort echo‐time (UTE) imaging is reported. The effects of T2 decay during signal acquisition on the 3D radial point‐spread function are analyzed and compared to 2D radial and 1D sampling. It is found that in addition to the use of ultrashort TE, the proper choice of the acquisition‐window duration TAQ is essential for imaging short‐T2 components. For 3D radial sampling, a maximal signal‐to‐noise ratio (SNR) with negligible decay‐induced loss in spatial resolution is obtained for an acquisition‐window duration of TAQ ≈ 0.69 T2. For 2D and 1D sampling, corresponding values are derived as well. Phantom measurements confirm the theoretical findings and demonstrate the impact of different acquisition‐window durations on SNR and spatial resolution for a given T2 component. In vivo scans show the potential of 3D UTE imaging with T2‐adapted sampling for musculoskeletal imaging using standard MR equipment. The visualization of complex anatomy is demonstrated by extracting curved slices from the isotropically resolved 3D UTE image data. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.
A 345 µW Multi-Sensor Biomedical SoC With Bio-Impedance, 3-Channel ECG, Motion Artifact Reduction, and Integrated DSP

This paper presents a MUlti-SEnsor biomedical IC (MUSEIC). It features a high-performance, low-power analog front-end (AFE) and fully integrated DSP. The AFE has three biopotential readouts, one bio-impedance readout, and support for general-purpose analog sensors The biopotential readout channels can handle large differential electrode offsets ( ±400 mV), achieve high input impedance ( >500 M Ω), low noise ( 620 nVrms in 150 Hz), and large CMRR ( >110 dB) without relying on trimming while consuming only 31 μW/channel. In addition, fully integrated real-time motion artifact reduction, based on simultaneous electrode-tissue impedance measurement, with feedback to the analog domain is supported. The bio-impedance readout with pseudo-sine current generator achieves a resolution of 9.8 m Ω/ √Hz while consuming just 58 μW/channel. The DSP has a general purpose ARM Cortex M0 processor and an HW accelerator optimized for energy-efficient execution of various biomedical signal processing algorithms achieving 10 × or more energy savings in vector multiply-accumulate executions.