Miracle-dz/UniFAR-FTUs huggingface dataset:
Chromosomal Translocation Apoptosis in Cells of an Infantile Leukemia Cell Line Carrying Chimeric Transcript Inhibits Cell Growth and Induces MLL-LTG 19 Antisense Oligodeoxyribonucleotide against the Updated

To clarify the role of the multiple lineage leukemia gene-leukemia translocation gene of chromosome 19 (MLL-LTG19) protein in leukemogenesis, we synthesized antisense Oligodeoxyribonucleotide (ODN) against the fused region of the MLL-LTG19 chimi-rie transcript and treated KOCL33 cells carrying the t(ll;19) translocation with antisense ODN. The antisense ODN inhibited cell growth and induced apoptosis in KOCL33 cells but not in Daudi cells, which have no nil:! 'Â»). The levels of MLL-LTG19 mRNA and MLL-LTG19 protein in KOCL33 cells treated with antisense ODN were shown to decrease with time by reverse transcription-PCR and Western blot analysis. These results suggest that the MLL-LTG19 fusion protein contributes to cell proliferation and malig nant transformation in infantile acute leukemia cells carrying the t(ll;19) translocation.
Preparation of Sesquiterpenoids from Tussilago farfara L. by High-speed Counter-current Chromatography

Background: Sesquiterpenoids, such as tussilagone, has effects of raising blood pressure, antiplatelet aggregation, and anti-inflammation activities, which is regarded as index compound for quality control of Tussilago farfara L. Objective: This study was aimed to obtain an effective method for fast isolation of sesquiterpenoids from T. farfara L. by high-speed counter-current chromatography (HSCCC). Materials and Methods: A solvent optimization method for HSCCC was presented, i.e., the separation factors of compounds after the K values of solvent system should be investigated. Results: A ternary solvent system of n-hexane:methanol:water (5:8:2, v/v/v) was selected and applied for the HSCCC, and 56 mg of tussilagone (2) was isolated from T. farfara L. , along with two other sesquiterpenoids 5.6 mg of 2,2-dimethyl-6-acetylchromanone (1) and 22 mg of 14-acetoxy-7 β-(3'-ethyl cis-crotonoyloxy)-lα-(2'-methylbutyryloxy)-notonipetranone (3) by HSCCC with high purities. Their chemical structures were elucidated by liquid chromatography-mass spectrometry and nuclear magnetic resonance experiments. Conclusion: These results offered an efficient strategy for preparation of potentially health-relevant phytochemicals from T. farfara L. , which might be used for further chemical research and pharmacological studies by preparative HSCCC. Abbreviations used: HSCCC: High-Speed Counter-Current Chromatography; LC-MS: Liquid Chromatograph-Mass Spectrometer; NMR: Nuclear Magnetic Resonance; TCM: Traditional Chinese Medicine; HPLC: High Performance Liquid Chromatography; ESI-MS: Electrospray Ionization Mass Spectrometry; PE: petroleum ether
Psychological measurement between physics and statistics

This contribution discusses the physical perspective on psychological measurement represented by additive conjoint measurement and the statistical perspective represented by item response theory, and argues that both fail to adequately address the real measurement problem in psychology: this is the absence of well-developed theories about psychological attributes. I argue that the two perspectives leave psychology out of the equation and by doing so come up with proposals for psychological measurement that are fruitless. Only the rigorous development of attribute theories can lead to meaningful measurement. I provide two examples of the measurement of theoretically well-developed attributes and suggest future directions for psychological measurement.
Thymus-derived Glucocorticoids Regulate Antigen-specific Positive Selection

While it is generally believed that the avidity of the T cell antigen receptor (TCR) for self antigen/major histocompatibility complex (MHC) determines a thymocyte's fate, how the cell discriminates between a stimulus that causes positive selection (survival) and one that causes negative selection (death) is unknown. We have previously demonstrated that glucocorticoids are produced in the thymus, and that they antagonize deletion caused by TCR cross-linking. To examine the role of glucocorticoids during MHC-dependent selection, we examined thymocyte development in organ cultures in which corticosteroid biosynthesis was inhibited. Inhibition of glucocorticoid production in thymi from α/β-TCR transgenic mice resulted in the antigen- and MHC-specific loss of thymocytes that normally recognize self antigen/MHC with sufficient avidity to result in positive selection. Furthermore, inhibition of glucocorticoid production caused an increase in apoptosis only in CD+CD8+ thymocytes bearing transgenic TCRs that recognized self antigen/MHC. These results indicate that the balance of TCR and glucocorticoid receptor signaling influences the antigen-specific thymocyte development by allowing cells with low-to-moderate avidity for self antigen/MHC to survive.
THE CONCEPTS OF BALANCE, CONGRUITY, AND DISSONANCE

The concept of consistency in man, a special case of a concept of universal consistency, has in recent years been productive of systematic theories and programs of research. Attitude change has been a focal area in this theoretical development. Consistency doctrines, however, lack specification of the conditions under which their predictions will hold. People like to make sense of their world, but they also seek out the magician to be entertained by incongruity. Historically the concept of consistency resembles the concept of vacuum in physics-a useful doctrine for organizing knowledge, although full of exceptions and contradictions. The author is an Assistant Program Director at the Research Center for Group Dynamics, an Assistant Professor of Psychology at the University of Michigan, and a member of the Editorial Board of Contemporary Psychology and of Human Relations.
Promoting social inclusion? The impact of village services on the lives of older people living in rural England

ABSTRACT Drawing on data from a qualitative study, this paper explores the impact of ‘village services’ on the lives of people aged 70 or more years living in rural England. Throughout the paper, the phrase ‘village services’ refers to six community-based services and activities provided to help meet the needs of older rural residents, namely lunch clubs, welfare rights information and advice services, befriending schemes and community warden support, in rural areas in three regions of England. It is argued that, in various ways, village services promote social inclusion by enhancing older rural residents' access to the resources, rights, goods and services that encourage social interaction and meaningful participation in community life. It is clear, however, that the overwhelming majority of users of village services are female, that older men are often reluctant to engage with the services on offer, and that the providers of village services need to find new and innovative ways of engaging with older men in rural areas. It is concluded that restricted revenue and capital resources means that the expansion of village services so that they may better meet the requirements of older rural men is unlikely.
Back to the Unchanging Past

The standard philosophical view of time travel has it that time travelers cannot change the past. It has been argued by some that the standard view is false, and that this can be shown using a two-dimensional model of time. I defend the standard view against this attack. I show, first, that the addition of a second temporal dimension does not provide a model of changing the past and, second, that neither does the addition of n temporal dimensions for any n > 1.
Secondary contact between Lycaeides idas and L. melissa in the Rocky Mountains: extensive admixture and a patchy hybrid zone

Studies of hybridization have increased our understanding of the nature of species boundaries, the process of speciation, and the effects of hybridization on the evolution of populations and species. In the present study we use genetic and morphological data to determine the outcome and consequences of secondary contact and hybridization between the butterfly species Lycaeides idas and L. melissa in the Rocky Mountains. Admixture proportions estimated from structure and geographical cline analysis indicate L. idas and L. melissa have hybridized extensively in the Rocky Mountains and that reproductive isolation was insufficient to prevent introgression for much of the genome. Geographical patterns of admixture suggest that hybridization between L. idas and L. melissa has led to the formation of a hybrid zone. The hybrid zone is relatively wide, given estimates of dispersal for Lycaeides butterflies, and does not show strong evidence of cline concordance among characters. We believe the structure of the Lycaeides hybrid zone might be best explained by the patchy distribution of Lycaeides, local extinction and colonization of habitat patches, environmental variation and weak overall selection against hybrids. We found no evidence that hybridization in the Rocky Mountains has resulted in the formation of independent hybrid species, in contrast to the outcome of hybridization between L. idas and L. melissa in the Sierra Nevada. Finally, our results suggest that differences in male morphology between L. idas and L. melissa might contribute to isolation, or perhaps even that selection has favoured the spread of L. melissa male genitalia alleles.
An exploration of participation in leisure activities post-stroke.

AIM The purpose of this study was to illuminate the experiences of older adults' return to leisure activities, following rehabilitation, post-stroke. METHOD A phenomenological approach was used to explore the experiences of re-engaging in leisure occupations post-stroke. In-depth interviews were conducted with five community-dwelling individuals (three men, two women) aged 68-74 years who had experienced a stroke in the past year. Data were analysed using thematic analysis. FINDINGS Four themes emerged: (i) Re-engaging in leisure activities, (ii) acceptance of physical limitations post-stroke, (iii) gratitude for help and support and (iv) looking forward to the future. CONCLUSION Implications revealed that post-stroke interventions need a more occupation-focussed approach, including return to leisure at an earlier stage of stroke rehabilitation.
Unsupervised soccer video abstraction based on pitch, dominant color and camera motion analysis

We present a soccer video abstraction method based on the analysis of the audio and video streams. This method could be applied to other sports as rugby or american football. The main contribution of this paper is the design of an unsupervised summarization method, and more specifically, the introduction of an efficient detector of excited speech segments. An excited commentary is supposed to correspond to an interesting moment of the game. It is simultaneously characterized by an increase of the pitch (or fundamental frequency) within the voiced segments and an increase of the energy supported by the harmonics of the pitch. The pitch is estimated from the autocorrelation function and its local increases are detected from a multiresolution technique. We introduce a specific energy measure for the voiced segments. A statistical analysis of the energy measures is performed to detect the most excited parts of the speech. A deterministic combination of excited speech detection, dominant color identification and camera motion analysis is then performed in order to discriminate between excited speech sequences of the game and excited speech sequences in commercials or in studio shots included in the processed TV programs. The method presented here does not need any learning stage. It has been tested on seven soccer videos for a total duration of almost 20 hours.
Recombinant Cysteine Proteinase from Leishmania (Leishmania) chagasi Implicated in Human and Dog T-Cell Responses

ABSTRACT High in vitro lymphoproliferative responses were induced in humans and dogs by a recombinant Leishmania (Leishmania) chagasi cysteine proteinase, with secretion of IFN-γ in asymptomatic subjects or of IFN-γ, interleukin 4 (IL-4), and IL-10 in oligosymptomatic subjects. In contrast, responses of symptomatic patients and dogs were lower, with production of IL-4 and IL-10.
Hantaan Virus Surveillance Targeting Small Mammals at Dagmar North Training Area, Gyeonggi Province, Republic of Korea, 2001–2005

ABSTRACT: In response to a hemorrhagic fever with renal syndrome case in November 2000, a seasonal rodent-borne disease surveillance program was initiated at Dagmar North Training Area (DNTA), Gyeonggi Province, Republic of Korea. From April 2001-December 2005, 1,848 small mammals were captured. Apodemus agrarius accounted for 92.5%, followed by Mus musculus (3.6%), Crocidura lasiura (2.1%), and Microtus fortis (1.1%). Three species of rodents were found to be antibody-positive (Ab+) for Hantaan virus (HTNV): A. agrarius (22.3%), M. musculus (9.1%), and M. fortis (5.0%). Ab+ rates for A. agrarius increased with increasing weight (age), except for those weighing <10 g. The peak HTNV transmission period in Korea coincided with the peak reproductive potential of A. agrarius during the fall (August/September) surveys. HTNV strains from DNTA were distinct from HTNV strains from the People's Republic of China. From these studies, more accurate risk assessments can be developed to better protect personnel from rodent-borne diseases.
Public Attitudes Toward Lethal Coyote Control

Predator control policies for coyotes are expensive and often controversial. A key aspect of this controversy is the public acceptability of different methods of coyote control, because some of the most controversial control methods are also the most cost-effective. This article casts further light on public preferences regarding lethal coyote control by analyzing data from Prince Edward Island, Canada. A distinction is made between the effects of sociodemographic characteristics on acceptability of control versus the acceptability of different lethal measures, based on damage caused by coyotes and rationale for control policies. The analysis confirms that lethal coyote control is more acceptable when coyotes are causing damage and that wildlife managers can minimize public opposition to control policies by carefully choosing among alternative methods of lethal control. I am grateful to Jerry Vaske and two anonymous referees for very useful comments on earlier drafts of the article. The project was funded by UCR grant No. 1308 St. Francis Xavier University.
The Picasso in Your Classroom How to Meet the Needs of Talented Artists in Elementary School

Cassidy, a talented artist in my third-grade classroom, struggled with classroom assignments. It’s not that she wasn’t capable of high-level work, but tasks such as spelling tests, arithmetic practice, and test preparation worksheets were making for a very unhappy child. Cassidy was consistently eager to participate in learning activities that had a visual arts component and would demonstrate focus and attention to detail, but her reading and math assignments were not completed with nearly the same care and proficiency. Her hasty work often included many incorrect answers and illegible writing, that is, if she would even complete the assignment at all. Most classroom indicators lead you to believe that Cassidy was a struggling learner; however, I had the good fortune of seeing a very different side of Cassidy through her artwork. Once, as an assignment to draw her family, she drew a flame to represent her dad’s warmth, a wave for her mother’s cool temperament, and a flower to represent her continued growth. This level of abstract thinking was certainly an indicator of her talent and abilities, but how could I tap into those abilities in the regular classroom?
In vivo function tests of hepatic drug‐oxidizing capacity in patients with liver disease

Aminopyrine, antipyrine and trimethadione have been widely used for some time as probe drugs to assess non‐selective P450 liver function. They have proved useful in evaluating pre‐ and post‐operative liver function when performing surgery, transplantations, etc., in addition to a general evaluation of liver function and drug interactions. Progress has recently been made both in these non‐selective P450 function tests and in the analysis of drug‐metabolizing enzymes at a molecular level, which has resulted in more selective P450 function tests.
Does the Dose of Acute Exercise Mediate Psychophysiological Responses to Mental Stress

This investigation examined the role that different doses of acute aerobic exercise (AE) have on psychophysiological responses to mental stress. Eighty women participated in one of four experimental conditions: (a) attention control, (b) 10 min of exercise, (c) 25 min of exercise, or (d) 40 min of exercise. All exercise sessions were performed at 70% of each subject's heart rate reserve. Following each condition, subjects rested for 20 min and then completed a modified Stroop test. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were monitored at rest and during the stressor. Positive and negative affect were assessed upon entry to the laboratory, postexercise (after the 20-min rest), prior to the stressor, and after a 5-min recovery period. A priori comparisons of the 40-min exercise condition versus the attention control manipulation revealed that a demanding bout of acute AE lowered DBP and MAP reactivity to the Stroop; however, there were no significant .
Undocumented Migration to the United States and the Wages of Mexican Immigrants

Prior work has documented the remarkable decline in the real wages of Mexican immigrant workers in the U.S. over the past several decades. Although some of this trend might be attributable to the changing characteristics of the migrants themselves, we argue that a more important change was the circumstances under within Mexican immigrants competed for jobs in the U.S. After 1986 a growing share of Mexican immigrants was undocumented, discrimination against them was mandated by federal law, and enforcement efforts rose in intensity. We combined data from the Mexican Migration Project (MMP) with independent estimates of the percentage undocumented among Mexicans living in the U.S. to estimate a series of regression models to test this hypothesis. Controlling for individual characteristics helps to explain the decline in the wages of immigrants, but does not eliminate the trend, which is only explained fully when the percentage undocumented is added to the model. A key date is 1986, confirmed by a Oaxaca—Blinder decomposition analysis, when undocumented hiring was criminalized and undocumented migration revived after IRCA's legalization programs ended. As the percentage undocumented rose to new heights in the face of employer sanctions, immigrant wages fell below what we would have observed under the former policy regime. Using newly available data from Warren and Warren (2013), we examined how variation in the percentage undocumented by state and year from 1990 through 2009 affected immigrant wages and confirmed a strong negative effect, but the addition of an interaction term to the model indicated that the negative effect was confined largely to undocumented migrants, whose wage penalty rose from 8 to 18 percent as the percentage undocumented rose from its observed minimum to maximum.
Memory Access Optimization of Motion Estimation Algorithms on a Native SIMD PLX Processor

With mostly non-sequential reference, memory access becomes the bottleneck of SIMD processor performance. In this paper, the authors present an approach for optimal H.264 motion estimation code generation over a SIMD platform with the objective to minimize memory access overhead. Specifically, we formulate the code generation task as a constrained optimization problem where the objective function is to minimize the amount of memory access overhead, subject to the constraint of the data-dependencies the algorithm. The target platform is based on a native SIMD processor architecture known as PLX developed at Princeton University. We illustrate with an example of generating PLX code for the H.264 variable-block size motion estimation algorithm. We show that the optimization yields significant performance enhancement
A study on the surveillance system using soft biometric information

Recently, with the spread of surveillance cameras, high-performance surveillance systems have been attracting much interest in information security and computer vision. On the other hand, there is also a need for simple surveillance systems that use less computer resources, have lower installation and operating costs, and consider the privacy of the people being identified. Moreover, human tracking and identification within and between cameras' views is required in surveillance systems. For this type of simple surveillance system, we propose a human tracking and identification method for within and between cameras' views by using soft biometric information. The results of the simulation using human gait video data confirmed the effectiveness of the proposed method.
Thematic structure and syntax: Revisiting English depictive predications

English depictive predicates have been analyzed as adjuncts, but their occurrences are not entirely free in that only certain types of predicates allow for the depictive predication constructions. Such restrictions have been analyzed in terms of the distinctions between Stage-Level Predicates and Individual-Level Predicates (Rapoport, 1993): both a main verb and a depictive predicate should be Stage-Level Predicates. However, I argue that the distinction is not sufficient to explain the English depictive predication constructions. Instead of the old distinctions, in this paper I suggest that it is more explanatory to analyze them on the bases of thematic roles: the predication subject of a depictive predicate bears either an agent or a theme role from a main verb. In this sense, I define them in terms of an Agent-Oriented Depictive (AOD) and a Theme-Oriented Depictives (TODs). They differ in that the AOD is predicated of the entity bearing an agent role, whereas the TOD is predicated of the entity bearing the theme role. The distinctive properties between AODs and TODs are explained by Thematic Hierarchy (Baker, 1988; Bresnan, 1989).