Miracle-dz/UniFAR-FTUs huggingface dataset:
Technology-based interventions in health care

There are several converging forces that create a particularly opportune time for technological solutions to enhance cost efficiency in healthcare. Health care costs are unsustainable, yet many patients do not have adequate access to state-of-the-art treatments or to ongoing disease management. Consumerism is an increasingly powerful force in healthcare and the emphasis on personalised medicine will help to define future research and clinical treatment strategies. At the same time, the phenomenal advances in internet utilisation and mobile device applications provide possibilities that have never before existed. We have reason to be very optimistic about these opportunities, but appropriate research will be required to develop scalable and sustainable methods as well as determine expected outcomes.
A Statistical Model for Simulating the Effect of LTPS TFT Device Variation for SOP Applications

In this paper, the variation characteristics of low-temperature polycrystalline silicon (LTPS) thin-film transistors (TFTs) are investigated with a statistical approach. A special layout is proposed to investigate the device variation with respect to various devices distances. Two non-Gaussian equations are proposed to fit the device parameter distributions, whose the coefficients of determination (R2) are both near 0.9, reflecting the validity of the model. Two benchmark circuits are used to compare the difference between the proposed model and the conventional Gaussian distribution for the device parameter distribution. The output behaviors of the digital and analog circuits show that the variation in the short range would greatly affect the performance of the analog circuits and would instead be averaged in the digital circuits.
Systematic Mutagenesis of the Saccharomyces cerevisiae MLH1 Gene Reveals Distinct Roles for Mlh1p in Meiotic Crossing Over and in Vegetative and Meiotic Mismatch Repair

ABSTRACT In eukaryotic cells, DNA mismatch repair is initiated by a conserved family of MutS (Msh) and MutL (Mlh) homolog proteins. Mlh1 is unique among Mlh proteins because it is required in mismatch repair and for wild-type levels of crossing over during meiosis. In this study, 60 new alleles of MLH1 were examined for defects in vegetative and meiotic mismatch repair as well as in meiotic crossing over. Four alleles predicted to disrupt the Mlh1p ATPase activity conferred defects in all functions assayed. Three mutations, mlh1-2, -29, and -31, caused defects in mismatch repair during vegetative growth but allowed nearly wild-type levels of meiotic crossing over and spore viability. Surprisingly, these mutants did not accumulate high levels of postmeiotic segregation at the ARG4 recombination hotspot. In biochemical assays, Pms1p failed to copurify with mlh1-2, and two-hybrid studies indicated that this allele did not interact with Pms1p and Mlh3p but maintained wild-type interactions with Exo1p and Sgs1p. mlh1-29 and mlh1-31 did not alter the ability of Mlh1p-Pms1p to form a ternary complex with a mismatch substrate and Msh2p-Msh6p, suggesting that the region mutated in these alleles could be responsible for signaling events that take place after ternary complex formation. These results indicate that mismatches formed during genetic recombination are processed differently than during replication and that, compared to mismatch repair functions, the meiotic crossing-over role of MLH1 appears to be more resistant to mutagenesis, perhaps indicating a structural role for Mlh1p during crossing over.
Preoperative Evaluation of Potential Living Related Kidney Donors with High-Spatial-Resolution Magnetic Resonance (MR) Angiography at 3 Tesla: Comparison with Intraoperative Findings

Purpose:The purpose of this prospective study was to determine the feasibility and accuracy of high-spatial-resolution MR imaging at 3 Tesla (T) in the preoperative evaluation of potential living related kidney donors. Materials and Methods:Eighteen potential donors (8 men, 10 women; mean age, 50.1 ± 14.2 years) for renal transplantation were evaluated with 3 T MR imaging. A high-spatial-resolution 3-dimensional (3D) gradient-echo MR angiography (repetition time/echo time, 3.0/1.14 ms; flip, 19–23°; matrix, 512; slice thickness, 1.0 mm) using parallel acquisition technique (GRAPPA) with an acceleration factor of 3 was performed on a whole body scanner. Images were evaluated in a prospective and blinded fashion by 2 MR radiologists. The number of renal arteries, presence of early branches (defined as a branch arising within 2 cm of the main renal ostium), and renal artery stenosis were analyzed. The renal parenchyma, collecting system and ureters, were evaluated on the MR urograms. Interpretation of MR images were compared with surgical findings. Results:Based on MR angiography data sets, a total of 36 main and 9 accessory renal arteries was found. There were 5 renal arteries presenting an early branching (≤2 cm). The correct venous anatomy was identified in 13 of 14 patients (93%), including a single left renal vein anterior to the aorta (n = 3), retroaortic left renal vein (n = 2), and single right renal vein (n = 9). A single collecting system in all harvested kidneys was identified correctly with MR imaging. Overall, the sensitivity and positive predictive value of MRI in correctly determining the vascular and parenchymal anatomy in the harvested kidney was 85% and 93%, respectively. Conclusions:High-spatial-resolution contrast-enhanced MR angiography at 3 T can predict successful donor nephrectomy in potential living related kidney donors.
GERMINATION, INITIAL GROWTH AND COTYLEDON PROTEIN CONTENT OF BEAN CULTIVARS UNDER SALINITY STRESS 1

4 ABSTRACT- Excess salts in the root zone inhibit water uptake by plants, affect nutrient uptake and may result in toxicities due to individual salts in the soil solution. Excess exchangeable sodium in the soil may destroy the soil structure to a point where water penetration and root aeration become impossible. Sodium is also toxic to many plants. Beans (Phaseolus vulgaris L.) are consumed as protein source in northeastern Brazil, although little is known about common bean cultivar tolerance to salinity. The germination of bean cultivars under salt stress was studied. The cultivars 'Carioca' and 'Mulatinho' were submitted to germination test in a germinator at 25 0 C, at the Seed Analysis Laboratory of the Brazilian Agricultural Research Corporation unit in the Semi- Arid region (Embrapa Semi Arido), Petrolina, Pernambuco State. These seeds were germinated on "germitest" papers imbibed in distilled water or in 10, 50, 100 e 200 mol.m -3 sodium chloride (NaCl) solutions. At the first and second counts of the germination test, normal seedlings were counted, measured, weighed and dried, supplying data for vigor, total germination, fresh matter weight and dry matter weight and seedlings length. Total protein was quantified in cotyledons at 3, 6 and 9 days after sowing. The results indicated that the NaCl content influenced seed germination and concentrations above 50 mol.m -3 decreased germination and seedling growth.
A plant's perspective of extremes: terrestrial plant responses to changing climatic variability

We review observational, experimental, and model results on how plants respond to extreme climatic conditions induced by changing climatic variability. Distinguishing between impacts of changing mean climatic conditions and changing climatic variability on terrestrial ecosystems is generally underrated in current studies. The goals of our review are thus (1) to identify plant processes that are vulnerable to changes in the variability of climatic variables rather than to changes in their mean, and (2) to depict/evaluate available study designs to quantify responses of plants to changing climatic variability. We find that phenology is largely affected by changing mean climate but also that impacts of climatic variability are much less studied, although potentially damaging. We note that plant water relations seem to be very vulnerable to extremes driven by changes in temperature and precipitation and that heatwaves and flooding have stronger impacts on physiological processes than changing mean climate. Moreover, interacting phenological and physiological processes are likely to further complicate plant responses to changing climatic variability. Phenological and physiological processes and their interactions culminate in even more sophisticated responses to changing mean climate and climatic variability at the species and community level. Generally, observational studies are well suited to study plant responses to changing mean climate, but less suitable to gain a mechanistic understanding of plant responses to climatic variability. Experiments seem best suited to simulate extreme events. In models, temporal resolution and model structure are crucial to capture plant responses to changing climatic variability. We highlight that a combination of experimental, observational, and/or modeling studies have the potential to overcome important caveats of the respective individual approaches.
Model order reduction of large scale power system by modal decomposition

This paper proposes an approach for estimating dynamic equivalents retaining the oscillatory modes through an optimal formulation. This approach defines equivalent generators for representing an external area while preserves the study area. The optimal formulation estimates the corresponding parameters of the equivalent generators, minimizing the difference between the main inter-area modes for the full and the reduced systems. The proposed model order reduction is applied to the Mexican interconnected high voltage grid. Simulation results demonstrate that the equivalent system may represent suitably the dynamic characteristics of the original system, diminishing the computing and analysis times.
Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase.

The ubiquitously expressed nonreceptor tyrosine kinase c-Abl contains three nuclear localization signals, however, it is found in both the nucleus and the cytoplasm of proliferating fibroblasts. A rapid and transient loss of c-Abl from the nucleus is observed upon the initial adhesion of fibroblasts onto a fibronectin matrix, suggesting the possibility of nuclear export [Lewis, J., Baskaran, R. , Taagepera, S. , Schwartz, M. & Wang, J. (1996) Proc. Natl. Acad. Sci. USA 93, 15174-15179]. Here we show that the C terminus of c-Abl does indeed contain a functional nuclear export signal (NES) with the characteristic leucine-rich motif. The c-Abl NES can functionally complement an NES-defective HIV Rev protein (RevDelta3NI) and can mediate the nuclear export of glutathione-S-transferase. The c-Abl NES function is sensitive to the nuclear export inhibitor leptomycin B. Mutation of a single leucine (L1064A) in the c-Abl NES abrogates export function. The NES-mutated c-Abl, termed c-Abl NES(-), is localized exclusively to the nucleus. Treatment of cells with leptomycin B also leads to the nuclear accumulation of wild-type c-Abl protein. The c-Abl NES(-) is not lost from the nucleus when detached fibroblasts are replated onto fibronectin matrix. Taken together, these results demonstrate that c-Abl shuttles continuously between the nucleus and the cytoplasm and that the rate of nuclear import and export can be modulated by the adherence status of fibroblastic cells.
Multipoint-to-multipoint routing for multimedia communication service

In the near future, it will be essential for multimedia networks to satisfy multiple quality of service (QoS) requirements, such as bandwidth, transmission reliability, end-to-end delay etc. On the other hand, multicast technology is being increasingly used in various continuous media applications that involve video and audio. In particular, multipoint-to-multipoint communication services, including multimedia collaborations such as video conferencing and shared workspaces, will be widespread. However, when a conventional multicast routing algorithm is applied to such services it may result in traffic concentration on some links. Therefore, we propose a new multipoint-to-multipoint routing method based on the Fallback+ algorithm, which can satisfy multiple QoS requirements and avoid traffic concentrations. Finally, simulation experiments show that this method results in improved traffic load balance and efficient use of network resources.
TEMPORAL AND SPATIAL VARIATION IN POLLINATION OF A MONTANE HERB: A SEVEN-YEAR STUDY

Pollination by animals is critical to sexual reproduction of most angiosperms. However, little is known about variation in pollination service to single plant species. We report results of a long-term study of Ipomopsis aggregata, a semelparous montane herb whose flowers are visited by hummingbird and insect pollinators as well as “floral larcenists. ” We censused flower visitors over seven summers at permanent study sites separated by several hundred meters, and counted pollen delivered to flowers on a subset of plants observed for visitation. The species composition of the community of visitors varied significantly across years and within the flowering season; sites varied significantly only in the magnitude of parallel annual changes in the visitor community. Rates of flower visitation fluctuated over an order of magnitude or more. Variation in mean stigma pollen load among plants flowering in the same site and year was explained by a causal path model in which visitation rates by pollinators and larcen.
The Adoption of ERP Applications in China

The adoption of enterprise resource planning (ERP) applications started in the early 1990s in the US and Europe. Although many researchers have studied the critical success factors (CSFs) or developed implementation framework to guide the deployment of the complex IT projects, there have been many failed implementations. The implementation of ERP systems in China began in the late 1990s but has resulted in a disappointing success rate of about 10 percent. This paper will investigate which issues facilitate or hinder the adoption of ERP applications in China in the light of previous research reported on Western firms. The research methodology is secondary data collection and case narratives. Twenty small case studies about the implementation of ERP systems in Chinese organisations will be discussed. Since the data has been collected and presented by other practitioners for certain purposes, the limitations of this research are also considered.
QbD-based carbopol transgel formulation: characterization, pharmacokinetic assessment and therapeutic efficacy in diabetes

Abstract In order to develop transdermal drug delivery system that facilitates the skin permeation of Pioglitazone (PZ) encapsulated in carbopol-based transgel system (proniosomes/niosome). The developed formulations were optimized using quality by design (QbD) approach and particle size, percentage entrapment and transdermal flux were determined. It was found to be more efficient delivery carriers with high encapsulation and enhanced flux value demonstrated that the permeation of PZ through skin was significantly increased with developed formulation. The transdermal enhancement from proniosome was 3.16 times higher than that of PZ from control formulation (ethanol buffer formulation, 3:7), which was further confirmed by confocal laser scanning microscopy. In vivo pharmacokinetic study of carbopol transgel showed a significant increase in bioavailability (2.26 times) compared with tablet formulation. It also showed better antidiabetic activity in comparison to marketed tablet, so our results suggest that carbopol-based transgel are an efficient carrier for delivery of pioglitazone through skin.
CHEWING PROBLEMS AND MORTALITY

sive effects. Both these effects contribute to regression of LVH and may explain the differences observed between treatment groups with regard to the LVH regressive effect in older adults. Various guidelines for the management of hypertension recommend ARBs as first-line treatment for people with hypertension with LVH. This study confirmed the efficacy of the ARB candesartan for regression of LVH in older adults as well as in adults with hypertension with LVH.
Mental disorders and comorbidity in suicide.

OBJECTIVE The purpose of this study was to investigate the prevalence and comorbidity of current mental disorders defined by DSM-III-R among a random sample of suicide victims from a nationwide suicide population. METHOD Using a psychological autopsy method, the authors collected comprehensive data on all suicide victims in Finland during 1 year. Retrospective axis I-III consensus diagnoses were assigned to 229 (172 male, 57 female) victims. RESULTS One or more diagnoses on axis I were made for 93% of the victims. The most prevalent disorders were depressive disorders (59%) and alcohol dependence or abuse (43%). The prevalence of major depression was higher among females (46%) than among males (26%). Alcohol dependence was more common among the males (39% versus 18% for females). A diagnosis on axis II was made for 31% and at least one diagnosis on axis III for 46% of the cases. Only 12% of the victims received one axis I diagnosis without any comorbidity. CONCLUSIONS The majority of suicide victims suffered from comorbid mental disorders. Comorbidity needs to be taken into account when analyzing the relationship between suicide and mental disorders and in planning treatment strategies for suicide prevention in clinical practice.
Characterization of an Integrable Single-Crystalline 3-D Tactile Sensor

Porous-Si-micromachining technique was used for the formation of single-crystalline force-sensor elements, capable of resolving the three vector components of the loading force. Similar structures presented so far are created from deposited polycrystalline Si resistors embedded in multilayered SiO2/Si3N4 membranes, using surface micromachining technique for a cavity formation. In this paper, the authors implanted four piezoresistors in an n-type-perforated membrane, having their reference pairs on the substrate in order to form four half bridges for the transduction of the mechanical stress. They successfully combined the HF-based porous-Si process with conventional doping and Al metallization, thereby offering the possibility of integration with readout and amplifying electronics. The 300times300 mum2 membrane size allows for the formation of large tactile arrays using single-crystalline-sensing elements of superior mechanical properties. They used the finite-element method for modeling the stress distribution in the sensor, and verified the results with real measurements. Finally, they covered the sensors with different elastic silicon-rubber layers, and measured the sensor's altered properties. They used continuum mechanics to describe the behavior of the rubber layer
Involvement of Phosphoinositide 3-Kinases in Neutrophil Activation and the Development of Acute Lung Injury1

Activated neutrophils contribute to the development and severity of acute lung injury (ALI). Phosphoinositide 3-kinases (PI3-K) and the downstream serine/threonine kinase Akt/protein kinase B have a central role in modulating neutrophil function, including respiratory burst, chemotaxis, and apoptosis. In the present study, we found that exposure of neutrophils to endotoxin resulted in phosphorylation of Akt, activation of NF-κB, and expression of the proinflammatory cytokines IL-1β and TNF-α through PI3-K-dependent pathways. In vivo, endotoxin administration to mice resulted in activation of PI3-K and Akt in neutrophils that accumulated in the lungs. The severity of endotoxemia-induced ALI was significantly diminished in mice lacking the p110γ catalytic subunit of PI3-K. In PI3-Kγ−/− mice, lung edema, neutrophil recruitment, nuclear translocation of NF-κB, and pulmonary levels of IL-1β and TNF-α were significantly lower after endotoxemia as compared with PI3-Kγ+/+ controls. Among neutrophils that did accumulate in the lungs of the PI3-Kγ−/− mice after endotoxin administration, activation of NF-κB and expression of proinflammatory cytokines was diminished compared with levels present in lung neutrophils from PI3-Kγ+/+ mice. These results show that PI3-K, and particularly PI3-Kγ, occupies a central position in regulating endotoxin-induced neutrophil activation, including that involved in ALI.
Recognizing Persons Climbing Fences

In this paper, we present two approaches to recognize a special type of human action, e.g. climbing a fence, from continuous monocular videos. Both approaches represent human activities as time series of discrete observations. In the first approach, we extract a feature vector from each frame, based on the relative configuration of human body parts against a fence. In the second approach, we propose a novel concept called "stable contact", to decompose the continuous human activities into adjacent but disjoint time intervals called primitive intervals. We then define a primitive motion unit (PMU) on each primitive interval with three attributes, thus converting each continuous activity into a sequence of PMUs. With the time series representations, we utilize Hidden Markov Model (HMM) techniques for recognition, including decoding in the first approach and searching in the second approach. Experimental results, on a set of image sequences with mixed human actions including walking and climbing a fence, show the effectiveness of the proposed methods. We compare the two approaches and discuss their applicability in different scenarios.
Composing with Absent Sound

This paper describes a process of ‘composing with absent sound’ in the realisation of Correlation Number One, an 8-channel computer music piece that uses high frequency tones to generate distortion-product otoacoustic emissions (DPOAE) in the listener’s ears. Following a survey of other works created using the phenomena, the artistic motivations and technical implementation of the piece are described. Through a reflection on form arising as a product of limitation in this case, that of the human auditory system a notion of the ear as an active, productive sense organ emerges, in contrast to contemporary sound studies discourse that favours a depiction of the ear as a passive receiver.
Functional imaging of procedural motor learning: Relating cerebral blood flow with individual subject performance

Changes of local synaptic activity during acquisition of a visuomotor skill were examined with positron emission tomography (PET) imaging of regional cerebral blood flow (rCBF). Eight subject learned the pursuit rotor task, a predictable tracking task, during three sequential PET scans (day 1). Subjects returned 2 days later and repeated the three pursuit trials and PET scans (day 2) after completing an extensive practice session. Control scans without movement bracketed the pursuit trials on both days to rule out time effects unrelated to motor skill learning. PET images were transformed to a common stereotaxic space using matched magnetic resonance imaging (MRI) scans. Group learning effects were determined by a repeated measures multivariate analysis of variance (ANOVA). During motor skill acquisition (day 1), increases of synaptic activity were identified in cortical motor areas and cerebellum, supporting the hypothesis that procedural motor learning occurs in motor execution areas. During long‐term practice (day 2), changes were limited to the bilateral putamen, bilateral parietal cortex, and left premotor cortex. To characterize differences in the rate of learning between subjects, each subject's performance data from day 1 was fit with a power function. The exponents were correlated with rCBF data on a pixel‐by‐pixel basis. Rapid skill acquisition was associated with increasing rCBF in premotor, prefrontal, and cingulate areas, and decreasing rCBF in visual processing areas located in the temporal and occipital cortex. This pattern in fast learners may reflect a more rapid shift from a visually guided strategy (accessing perceptual areas) to an internally generated model (accessing premotor and prefrontal areas). © 1994 Wiley‐Liss, Inc.