Miracle-dz/UniFAR-FTUs huggingface dataset:
Bone metastasis in breast cancer is treated by high-dose tamoxifen.

PURPOSE Bone metastases in breast cancer are quite common, and some patients may have no other site of metastasis. An effective treatment is often endocrine agents administration (tamoxifen or antiaromatases), given mainly to postmenopausal women. Radiation treatment is also effective, although difficult to perform in cases of extensive skeletal disease. Chemotherapy does not help. The purpose of this study was to investigate the effectiveness of high-dose tamoxifen in female patients with breast cancer and bone metastasis. METHODS 28 patients with breast cancer were treated with high-dose tamoxifen. All of them had been pretreated with hormonal therapy including low-dose tamoxifen. RESULTS The results were extremely positive with clinical amelioration and also disappearance of osteolysis in some patients. Twenty six out of 28 patients responded to the treatment, the criteria being mainly pain reduction and body mobilization (an amelioration which lasted 8 months-4 years). CONCLUSION Tamoxifen is efficient when readministered at high dose to breast cancer patient with bone metastasis.
Design and Creation of Ontologies for Environmental Information Retrieval1

1. Copyright MCC and Telcordia Technologies, Inc., 1999. Domain Specific Ontologies are increaingly being used for information gathering and analysis over distributed and networked information sources. An example of such a system is the InfoSleuth system, where agents interpret user queries based on a domain specific ontology and cooperate with each other to retrieve the data corresponding to a query. We discuss the EDEN system for environmental information, where the ontology thus plays a crucial role. We propose an approach for designing an ontology for information retrieval based on: (a) the schemas of the databases; and (b) a collection of queries that are of interest to the users. In some cases, standardized vocabularies and data dictionaries may also aid the design and creation of the ontology. Our approach is presented in the context of the environmental information domain and minimizes the need for involvement of a domain expert for ontology construction. We discuss the EDEN ontology which was developed based on the environmental databases, CERCLIS 3, ITT, ERPIMS, HAZDAT, the data identified by the Basel Convention; and the set of user queries proposed by the user group. We discuss how an environmental data dictionary, the EDR repository and a standardized vocabulary such as the GEMET thesaurus can be used to improve the EDEN ontology.
Molecular characterization and transcriptional analysis of type 8 capsule genes in Staphylococcus aureus

A 20.5-kb contiguous DNA fragment from Staphylococcus aureus Becker affecting type 8 capsule (CP8) biosynthesis was previously cloned. Sequencing analysis indicated that 16 open reading frames (ORFs) encoded within this fragment might be involved in CP8 synthesis. Using various plasmids containing DNA inserts derived from the 20.5-kb region, we showed by complementation of chemical mutants that 8 of the 16 ORFs were required for CP8 synthesis. To determine the involvement of the remaining eight ORFs, nonpolar gene-specific chromosomal mutations located in each of these ORFs were constructed. We found that three additional ORFs were also involved in the CP8 synthesis. Thus, 11 of the 16 ORFs were shown to affect CP8 synthesis. Complementation analyses of these 11 type 8 capsule (cap8) genes affecting CP8 production showed several promoters within the cap8 gene cluster. However, by Northern hybridization using either the entire cap8 gene cluster or the internal fragments of individual ORFs as probes, one 17-kb cap8-specific transcript was detected. Using xylE as the reporter gene, we found that the promoter at the beginning of the cap8 operon was much stronger than any of the internal promoters. These results suggest that the cap8 genes are transcribed mainly as a single large transcript. In addition, Southern hybridization analyses showed that cap8H, cap8I, cap8J, and cap8K, located in the central region of the cap8 gene cluster, were CP8 specific.
Relationships between working memory and intelligence from a developmental perspective: Convergent evidence from a neo-Piagetian and a psychometric approach

The objective of this paper, in line with the other papers of this special issue, is to show the potentialities of combining intelligence research and cognitive psychology. The development of intelligence is here addressed from two usually separate perspectives, a psychometric one, and a neo-Piagetian one. Two studies are presented. In Experiment 1, children aged 6, 7, 9, and 11 years (N = 100) were administered two working memory tasks and three Piagetian tasks. In Experiment 2, children aged 8–12 years (N = 207), young adults aged 20–35 (N = 160), and older adults aged 60–88 years (N = 135) were administered working memory and processing speed tasks, as well as the Raven Standard Matrices task. Regression and commonality analyses were run to analyse the age-related variance in the Piagetian tasks (Study 1), and in the Raven task (Study 2). In both experiments, working memory accounted for a large part of the age differences observed, but more so in Study 1 (Piagetian tasks) than in Study 2 (Raven task). It is concluded that working memory mediates the effect of age on fluid intelligence during childhood and during adulthood.
On the fusion matrix of the N=1 Neveu-Schwarz blocks

We propose an exact form of the fusion matrix of the Neveu-Schwarz blocks that appear in a correlation function of four super-primary fields. Orthogonality relation satisfied by this matrix is equivalent to the bootstrap equation for the four-point super-primary correlator in the N = 1 supersymmetric Liouville field theory.
Selected Pool of Peptides from ESAT-6 and CFP-10 Proteins for Detection of Mycobacterium tuberculosis Infection

ABSTRACT We have validated a new test for detecting Mycobacterium tuberculosis infection. A pool of synthetic peptides derived from ESAT-6 and CFP-10 proteins was used to detect the number of specific gamma interferon-producing T cells by means of an enzyme-linked immunospot assay. Sixty-eight individuals positive for M. tuberculosis infection, either human immunodeficiency virus-seropositive or -seronegative, were studied. The test results were highly specific (87.5%) and sensitive (93.1%), more so than a classical lymphoproliferative assay (specificity and sensitivity of 77.27%), opening new possibilities for diagnosis and screening of tuberculosis. Moreover, the test allowed us to distinguish individuals infected with M. tuberculosis from those vaccinated with BCG.
Estructura conductual en deportes sociomotores: fútbol

Resumen Este estudio presenta un modelo probabilístico para el fútbol construido a partir de la observación de diversos partidos de fútbol de primera división de la liga española. Este modelo aporta más información que los tradicionales análisis que consideran únicamente cómo se ganaron partidos o se perdieron. La capacidad de predicción del modelo, a pesar del restringido número de conductas observadas (tiros, pérdidas, recuperaciones y posicionamientos defensivos) y los resultados asociados (a las zonas y a los errores) es variable. Un jugador no produce siempre la misma conducta consistente ante la misma situación cuando compite contra equipos diferentes, no obstante se asume que existe un grado de incertidumbre en cuanto a saber si los resultados son una función particular del análisis empleado. No cabe duda que la predicción de la conducta deportiva es una manera de buscar datos críticos acerca de la ejecución deportiva. Para llevar a cabo este trabajo se ha construido un sistema de categorías para observar la acción de juego en el fútbol. La codificación del flujo de conducta obtenido con la utilización de este sistema de categorías es sometido a un análisis secuencial utilizando la técnica de retardos. Los patrones de conducta estimados son cotejados con los resultados obtenidos de someter estos mismos datos a un análisis de Permutaciones Exactas. Finalmente se describen los principales patrones de conducta y sus correspondientes implicaciones psicosociales. La característica más destacada del trabajo, además de la utilización de software específico tanto en la codificación como en el análisis de los registros observacionales, es la propuesta de un modelo predictivo.
Dynamics and Genetics of Hippocampal Network Activity

Ongoing neuronal oscillations in vivo exhibit non-random amplitude fluctuations as reflected in a slow decay of temporal auto-correlations that persist for tens of seconds. Interestingly, the decay of auto-correlations is altered in several brainrelated disorders, including epilepsy, depression and Alzheimer’s disease, suggesting that the temporal structure of oscillations depends on intact neuronal networks in the brain. Whether structured amplitude modulation occurs only in the intact brain or whether isolated neuronal networks can also give rise to amplitude modulation with a slow decay is not known. Here, we examined the temporal structure of cholinergic fast network oscillations in acute hippocampal slices. For the first time, we show that a slow decay of temporal correlations can emerge from synchronized activity in isolated hippocampal networks from mice, and are maximal at intermediate concentrations of the cholinergic agonist carbachol. Using zolpidem, a positive allosteric modulator of GABAA-receptor function, we found that increased inhibition leads to longer oscillation bursts and more persistent temporal correlations. In addition, we asked if these findings were unique for mouse hippocampus, and we, therefore, analyzed cholinergic fast network oscillations in rat prefrontal cortex slices. We observed significant temporal correlations, which were similar in strength to those found in mouse hippocampus and in human cortex. Taken together, our data indicate that fast network oscillations with temporal correlations can be induced in isolated networks in vitro in different species and brain areas and, therefore, may serve as model systems to investigate how altered temporal correlations in disease may be rescued with pharmacology.
Activation/Division of Lymphocytes Results in Increased Levels of Cytoplasmic Activation/Proliferation-Associated Protein-1: Prototype of a New Family of Proteins1

We purified from activated T lymphocytes a novel, highly conserved, 116-kDa, intracellular protein that occurred at high levels in the large, dividing cells of the thymus, was up-regulated when resting T or B lymphocytes or hemopoietic progenitors were activated, and was down-regulated when a monocytic leukemia, M1, was induced to differentiate. Expression of the protein was highest in the thymus and spleen and lowest in tissues with a low proportion of dividing cells such as kidney or muscle, although expression was high in the brain. The protein was localized to the cytosol and was phosphorylated, which is consistent with a previous report that the Xenopus laevis ortholog was phosphorylated by a mitotically activated kinase (1 ). The cDNA was previously mischaracterized as encoding p137, a 137-kDa GPI-linked membrane protein (2 ). We propose that the authentic protein encoded by this cDNA be called cytoplasmic activation/proliferation-associated protein-1 (caprin-1), and show that it is the prototype of a novel family of proteins characterized by two novel protein domains, termed homology regions-1 and -2 (HR-1, HR-2). Although we have found evidence for caprins only in urochordates and vertebrates, two insect proteins exhibit well-conserved HR-1 domains. The HR-1 and HR-2 domains have no known function, although the HR-1 of caprin-1 appeared necessary for formation of multimeric complexes of caprin-1. Overexpression of a fusion protein of enhanced green fluorescent protein and caprin-1 induced a specific, dose-dependent suppression of the proliferation of NIH-3T3 cells, consistent with the notion that caprin-1 plays a role in cellular activation or proliferation.
Improving activity recognition via automatic decision tree pruning

Activity recognition enables many user-facing smartphone applications, but it may suffer from misclassifications when trained models attempt to classify previously-unseen real-world behavior. Our system mitigates this problem by first identifying spurious classifications and then automatically pruning a decision tree model to remove labels that tend to produce wrong inferences, resulting in a 10% classification improvement based on our data set.
Adaptation of Perceptual Responses to Low-Load Blood Flow Restriction Training

Abstract Martín-Hernández, J, Ruiz-Aguado, J, Herrero, AJ, Loenneke, JP, Aagaard, P, Cristi-Montero, C, Menéndez, H, and Marín, PJ. Adaptation of perceptual responses to low-load blood flow restriction training. J Strength Cond Res 31(3): 765–772, 2017—The purpose of this study was to determine the adaptive response of ratings of perceived exertion (RPE) and pain over 6 consecutive training sessions. Thirty subjects were assigned to either a blood flow restriction training (BFRT) group or a high-intensity resistance training (HIT) group. Blood flow–restricted training group performed 4 sets (30 + 15 + 15 + 15, respectively) of unilateral leg extension at an intensity of 20% one repetition maximum (1RM) while a restrictive cuff was applied to the most proximal part of the leg. The HIT group performed 3 sets of 8 repetitions with 85% 1RM. Ratings of perceived exertion and pain were assessed immediately after each exercise set along the 6 training sessions and were then averaged to obtain the overall RPE and pain per session. Statistical analyses showed significant main effects for group (p ⩽ 0.05) and time (p < 0.001). Ratings of perceived exertion values dropped from session 1 to session 6 in both BFRT (8.12 ± 1.3 to 5.7 ± 1.1, p < 0.001) and HIT (8.5 ± 1.2 to 6.40 ± 1.2, p < 0.001). Similar results were observed regarding pain ratings (BFRT: 8.12 ± 1.3 to 5.90 ± 1.55, p < 0.001; HIT: 6.22 ± 1.7 to 5.14 ± 1.42, p < 0.01). Our results indicate that RPE was higher after HIT, whereas differences did not reach significance regarding pain. These perceptual responses were attenuated over time, and the time course of this adaptive response was similar between BFRT and HIT. In summary, BFRT induces a marked perceptual response to training, comparable with that observed with HIT. However, this response becomes attenuated with continuous practice, leading to moderate values of RPE and pain. Perceptual responses may not limit the application of BFRT to highly motivated individuals.
Network-coding-based video transmission via WiFi direct in local mobile networks

It will incur high expense by sharing large-scale files (such as video) with others through commercial 4G networks. When the users are located at the same area, the traffic cost could be saved via the technology of WiFi direct. In this paper, a network-coding-based video transmission scheme is proposed for such scenario. In the scheme, when a source user needs to transmit a video to others, it equally splits the original file into multiple segments. When a neighbour connects to it and requests a segment, the user will linearly generate a new segment with all the segments it buffers, and then send the re-encoded segment to other neighbours. After the neighbours receive all or part of the segments, they could become a new source and send data to their own neighbours through the technology of WiFi direct. The results show that compared with the traditional scheme, the transmission scheme based on network coding could be used to complete transmission at a higher rate.
Are People with Intellectual Disabilities Getting More or Less Intelligent?

It has been well documented that over the last 60 years there has been a gradual increase in the intellectual ability of the population as a whole which has included people with low intellectual ability. The present study examined if this trend was still continuing in the UK by comparing the scaled scores given for individual raw scores on three common subtests (Symbol Search, Coding, and Digit Span) of the UK versions of the WISC-III and WISC-IV. It was found that over the 12.5 years between the two assessments being standardised there was an overall increase in intellectual ability. However, this increase was greater for those with high intellectual ability. For those with low intellectual ability there was a decline in their intellectual ability.
Total k-independence in Digraphs

Let k ≥ 2 be an integer. A function f : V(D)→ {−1, 1} defined on the vertex set V(D) of a digraph D is a signed total k-independence function if ∑ x∈N−(v) f (x) ≤ k − 1 for each v ∈ V(D), where N−(v) consists of all vertices of D from which arcs go into v. The weight of a signed total k-independence function f is defined by w( f ) = ∑ x∈V(D) f (x). The maximum of weights w( f ), taken over all signed total k-independence functions f on D, is the signed total k-independence number αst(D) of D. In this work, we mainly present upper bounds on αst(D), as for example α k st(D) ≤ n − 2d(∆− + 1 − k)/2e and αst(D) ≤ ∆ + 2k − δ − 2 ∆+ + δ+ · n, where n is the order, ∆− the maximum indegree and ∆ and δ are the maximum and minimum outdegree of the digraph D. Some of our results imply well-known properties on the signed total 2-independence number of graphs. 1. Terminology and Introduction In this paper, all digraphs are finite without loops or multiple arcs. The vertex set and arc set of a digraph D are denoted by V(D) and A(D), respectively. The order n = n(D) of a digraph D is the number of its vertices. If uv is an arc of D, then we write u→ v, and we say that v is an out-neighbor of u and u is an in-neighbor of v. For a vertex v of a digraph D, we denote the set of in-neighbors and out-neighbors of v by N−(v) = N− D(v) and N(v) = N D(v), respectively. The numbers d − D(v) = d −(v) = |N−(v)| and d+D(v) = d(v) = |N+(v)| are the indegree and outdegree of v, respectively. The minimum indegree, maximum indegree, minimum outdegree and maximum outdegree of D are denoted by δ− = δ−(D), ∆− = ∆−(D), δ = δ(D) and ∆ = ∆(D), respectively. A digraph D is called inregular or r-inregular if δ−(D) = ∆−(D) = r and outregular or r-outregular if δ(D) = ∆(D) = r. We say that D is regular or r-regular if it is r-inregular and r-outregular. If X ⊆ V(D) and v ∈ V(D), then E(X, v) is the set of arcs from X to v and E(v,X) the set of arcs from v to X. If X and Y are two disjoint vertex sets of a digraph D, then E(X,Y) is the set of arcs from X to Y. The number of vertices of odd indegree and even indegree are denoted by no and ne, respectively. If X ⊆ V(D) and f is a mapping from V(D) into some set of numbers, then f (X) = ∑ x∈X f (x). For a vertex v in V(D), we denote f (N−(v)) by f [v] for notational convenience. The associated digraph D(G) of a graph G is the digraph obtained from G when each edge e of G is replaced by two oppositely oriented arcs with the same ends as e. 2010 Mathematics Subject Classification. Primary 05C20 ; Secondary 05C69,
Electrical characterization of DNA molecules in solution using impedance measurements

We report on impedance measurements of fluids to examine the impact of the length and concentration of free-floating double-stranded DNA molecules. The impedance versus frequency characteristics were fitted to an equivalent circuit model including solution dielectric capacitance and conductance. The extraction of these parameters can be used to detect the presence of DNA molecules in the nanomolar range for a 400bp long molecule. Our results show that the extracted dielectric capacitance and conductance increase with molecule length and concentration owing to a corresponding increase in number of molecule dipoles and counterions in solution.
HYBRID DATAGATHERING SCHEME FOR ENERGY EFFICIENT WIRELESS SENSOR NETWORKS

Due to their ease of deployment, reliability, scalability, flexibility, and self-organization, the existing and potential applications of Wireless Sensor Networks (WSN's) span a wide spectrum in various domains, the environmental and technical requirements of which may differ significantly. The major bottle neck in WSN based data collection is the limited power back up. Due to some hostile environments periodic charging of wireless nodes is also not possible. The purpose of deploying a WSN is to collect relevant data for processing and reporting. In particular, based on data reporting, WSNs can be classified as time-driven, event-driven and data driven. In this paper, a hybrid data-gathering protocol that dynamically switches between the eventdriven data-reporting and data-driven data-reporting schemes is proposed. The novel aspect of this approach is that sensor nodes that seem to detect an event of interest in the near future, as well as those nodes detecting the event, become engaged in the adaptive transmission based data-reporting process. This capability enables data from neighboring nodes to be gathered proactively without requiring observer intervention. As such, the proposed protocol accurately analyzes the environment being monitored using only moderate resource consumption. The method makes a tradeoff between the energy consumption and data accuracy. The two algorithms named parameter-based Event Detection (PED) for dynamic switching and Parameter-based Area Detection (PAD) for area coverage are proposed and the effectiveness of the algorithm in a wireless scenario is
Toward an input-based perspective on categorization: : Investor reactions to chemical accidents

We build on the literature on categorization to develop and test a model of input-level spillover effects. Our model predicts that, when one firm suffers an accident with a particular input, investors will punish other users of that input by discounting their stocks, and that the magnitude of this negative spillover can be predicted by the nonresponsible firm’s level of input usage. We also hypothesize that the magnitude of the punishment will be moderated by intermediaries’ assessments of the input: Ex ante regulatory sanctions on the input will amplify negative spillovers, while the presence of input-level associations will weaken these effects. Finally, we predict that similarity between the responsible and nonresponsible firm in terms of two peripheral attributes— input portfolio and geographic location—will amplify the negative effect of input usage. We find strong support for our predictions in an event study that examines the stock market valuations of 270 nonresponsible manufacturing firms triggered by 78 industrial accidents involving a toxic chemical. We highlight our study’s theoretical and empirical contributions to the categorization and spillover literatures