Miracle-dz/UniFAR-FTUs huggingface dataset:
Semefulness: a social semiotics of touch

This paper explores the multiple significances (semefulness) of touch, as experienced by us as embodied subjects. Prompted by the development of a range of touch-based technologies, I consider the current writings about touch in a range of fields and how these have contributed to contemporary understandings of the meanings of touch. I then explore a number of these meanings – connection, engagement, contiguity, differentiation, positioning – for their contribution to our understanding of the world and of our own embodied subjectivity. I also explore the deployment of these meanings by contemporary technologies.
Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell- mediated immunity

BALB/c mice infected with the intracellular protozoan Leishmania major mount a T helper cell 2 (Th2) response that fails to control growth of the parasite and results in the development of visceral leishmaniasis. Separation of CD4+ T cells into CD45RBhigh and CD45RBlow subsets showed that the L. major-specific Th2 cells were contained within the CD45RBlow population as these cells produced high levels of antigen- specific interleukin 4 (IL-4) in vitro and transferred a nonhealing response to L. major-infected C.B-17 scid mice. In contrast, the CD45RBhighCD4+ population contained L. major-reactive cells that produced interferon gamma (IFN-gamma) in vitro and transferred a healing Th1 response to L. major-infected C.B-17 scid mice. Transfer of the Th1 response by the CD45RBhigh population was inhibited by the CD45RBlow population by a mechanism that was dependent on IL-4. These data indicate that L. major-specific Th1 cells do develop in BALB/c mice, but their functional expression is actively inhibited by production of IL-4 by Th2 cells. In this response, the suppressed Th1 cells can be phenotypically distinguished from the suppressive Th2 cells by the level of expression of CD45RB. Although the CD45RBhigh population mediated a protective response to L. major, C.B-17 scid mice restored with this population developed a severe inflammatory response in the colon that was independent of L. major infection, and was prevented by cotransfer of the CD45RBlow population. The colitis appeared to be due to a dysregulated Th1 response as anti-IFN-gamma, but not anti-IL-4, prevented it. Taken together, the data show that the CD4+ T cell population identified by high level expression of the CD45RB antigen contains cells that mediate both protective and pathogenic Th1 responses and that the reciprocal CD45RBlow population can suppress both of these responses. Whether suppression of cell- mediated immunity is beneficial or not depends on the nature of the stimulus, being deleterious during L. major infection but crucial for control of potentially pathogenic inflammatory responses developing in the gut.
A focus on gender similarities in work experiences in senior management

Purpose – The purpose of this paper is to propose a shift in emphasis from gender differences to gender similarities in the explanations of the findings of future gender in management research. The results from a study in a major Australian bank help build the case. Such a focus on gender similarities (FGS) hopefully will bring about positive organizational change that might stimulate an increase in women's representation in senior management in the future.Design/methodology/approach – To make a case for the proposed FGS approach the paper uses results from a survey of 178 senior managers and interviews with 14 executives in one Australian bank. The paper draws on the masculine culture and organizational silence literatures to explain how women and men in senior management can have similar work experiences and hold similar views of their organizations.Findings – The paper finds that male and female respondents held similarly unfavorable views of the organization's culture, but men felt constrained in rais.
Extracting and Aggregating False Information from Microblogs

During the 2011 East Japan Earthquake and Tsunami Disaster, we had found a number of false information spread on Twitter, e.g., “The Cosmo Oil explosion causes toxic rain. ” This paper extracts pieces of false information exhaustively from all the tweets within one week after the earthquake. Designing a set of linguistic patterns that correct false information, this paper proposes a method for detecting false information. More specifically, the method extracts text passages that match to the correction patterns, clusters the passages into topics of false information, and selects, for each topic, a passage explaining the false information the most suitably. In the experiment, we report the performance of the proposed method on the data set extracted manually from Web sites that are specialized in collecting false information.
Efficient Diagnosis of Vulvovaginal Candidiasis by Use of a New Rapid Immunochromatography Test

ABSTRACT The clinical symptoms of vulvovaginal candidiasis (VVC) are nonspecific, and misdiagnosis is common, leading to a delay in the initiation of antifungal treatment. We evaluated a new immunochromatography test (ICT), the CandiVagi assay (SR2B, Avrille, France), for the rapid diagnosis of VVC. This test, which employs an immunoglobulin M antibody directed against the β-1,2-mannopyranosyl epitopes found in the yeast cell wall, was compared with direct microscopic examination and culture of vaginal swabs. Two-hundred five women were investigated, including 130 women with symptomatic vaginitis and 75 asymptomatic controls. Two vaginal swabs were obtained from each woman: one was used to prepare a wet mount and Gram-stained preparations for direct microscopic examination and was also cultured on Sabouraud dextrose agar for the isolation of Candida spp. , and the second swab was used for ICT. The sensitivities of microscopic examination, culture, and ICT for the diagnosis of VVC were 61%, 100%, and 96.6%, respectively, while the specificities of the three methods were 100%, 82%, and 98.6%, respectively. ICT had a negative predictive value of 98.6%, a positive predictive value of 96.6%, and an efficiency of 98%. ICT provided a rapid result and a better compromise between sensitivity and specificity than conventional microscopy and culture for the diagnosis of VVC. This easy-to-perform diagnostic test will be useful to practitioners treating women with symptoms of vaginitis.
Come-ons and Put-offs: Unmarried Students' Strategies for Having and Avoiding Sexual Intercourse

One-hundred and twenty male and 109 female unmarried college students participated in a questionnaire study of actual and expected male-female differences in the use of 10 strategies for having and avoiding sexual intercourse. As predicted, both men and women viewed strategies for having sex as used predominantly by males and strategies for avoiding sex as used predominantly by females. However, sex-role attitudes were unrelated to students' expectations of sexual encounters. Both traditional and profeminist students expected that strategies for having sex would be used predominantly by males and strategies for avoiding sex would be used predominantly by females. It appeared that students still stereotyped having sex as a male goal and avoiding sex as a female goal. Men and women were unexpectedly similar in their personal strategies for influencing a sexual encounter. Both men and women reported using more indirect strategies to have sex and more direct strategies to avoid having sex. These findings suggest that when men and women share the same goals (such as having or avoiding sex), expected differences between male and female influencing agents disappear
Improved 3D assisted pose-invariant face recognition

Recent face recognition algorithm can achieve high accuracy when testing face samples are frontal. However, when face pose changes largely, the performance of existing methods drop drastically. In this paper, we propose an improved algorithm aiming at recognizing faces of different poses when each face class has only one frontal training sample. For each sample, a 3D face is constructed by using 3D Morphable Model (3DMM). The shape and texture parameters of 3DMM are recovering by fitting the model to the 2D face sample which is a non-linear optimization problem. The virtual faces of different views are generated from the 3DMM to assist face recognition. Different from the conventional optimization energy function, proposed energy function takes not only image intensity but also shape constraint into account. In this paper, we locate 88 sparse points from the 2D face sample by automatic face fitting and use their correspondence in the 3D face as shape constraint. We experiment proposed method on the publicly available CMUPIE database which includes faces viewed from 11 different poses and the results show that proposed method is effective and the face recognition results towards pose-variant are promising.
NoC-MRAM architecture for memory-based computing: Database-search case study

The paper presents a novel flexible low-power architecture for memory-based computing that relies on a NoC and power-gated distributed MRAM. The proposed approach is demonstrated with a database search application implemented with a Sparse-Neural-Network (SNN). Multiple SystemC simulations have been conducted over the MRAM-based computing architecture targeting hundreds of database queries. The results show hit rates of about 95%, impressive power gains compared to SRAM, and significant impact of power-gating. The results also provide an evidence on the feasibility of using power-gated MRAM associated with a NoC as a solution for low power implementation of memory-based computing.
Cyclin B-Cdk1 Kinase Stimulates ORC- and Cdc6-Independent Steps of Semiconservative Plasmid Replication in Yeast Nuclear Extracts

ABSTRACT Nuclear extracts from Saccharomyces cerevisiae cells synchronized in S phase support the semiconservative replication of supercoiled plasmids in vitro. We examined the dependence of this reaction on the prereplicative complex that assembles at yeast origins and on S-phase kinases that trigger initiation in vivo. We found that replication in nuclear extracts initiates independently of the origin recognition complex (ORC), Cdc6p, and an autonomously replicating sequence (ARS) consensus. Nonetheless, quantitative density gradient analysis showed that S- and M-phase nuclear extracts consistently promote semiconservative DNA replication more efficiently than G1-phase extracts. The observed semiconservative replication is compromised in S-phase nuclear extracts deficient for the Cdk1 kinase (Cdc28p) but not in extracts deficient for the Cdc7p kinase. In a cdc4-1 G1-phase extract, which accumulates high levels of the specific Clb-Cdk1 inhibitor p40 SIC1 , very low levels of semiconservative DNA replication were detected. Recombinant Clb5-Cdc28 restores replication in a cdc28-4 S-phase extract yet fails to do so in the cdc4-1 G1-phase extract. In contrast, the addition of recombinant Xenopus CycB-Cdc2, which is not sensitive to inhibition by p40 SIC1 , restores efficient replication to both extracts. Our results suggest that in addition to its well-characterized role in regulating the origin-specific prereplication complex, the Clb-Cdk1 complex modulates the efficiency of the replication machinery itself.
Avaliação da prática de gerenciamento de resultados na apuração de lucro por companhias abertas brasileiras conforme seu grau de alavancagem financeira

This paper investigates the existence of earnings management and its association with leverage for Brazilian listed firms. The first section presents related research. The Model of Jones modified for the estimate of the discretionary countable adjustments was used, which indicated existence of earnings management in the examined firms; however it did not achieve to confirm with statistical significance that such practices were associated with its levels of indebtedness.
Receptor binding and functional selectivity of WNTs

To whom the correspondence should be addressed: Gunnar Schulte, Section of Receptor Biology & Signaling, Dept. Physiology & Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden. Tel. : +46-8-52487933; Fax: +46-8-341280; E-mail: gunnar.schulte@ki.se Rami N. Hannoush, Department of Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, United States. Tel. : +1-650-467-3696; E-mail: hannoush.rami@gene.com
Novel SVPWM switching pattern for high efficiency 15KW current-fed quasi-Z-source inverter in HEV motor drive application

The recently proposed current-fed QZSI[1] can buck and boost voltage and provide bidirectional power flow[2-6]. A crucial criterion for the size of three phase PWM converters is the cooling of the power semiconductors and thus determination of power dissipation at certain operating points. In the modified SVPWM control method for this circuit, different PWM sequences can lead to different switching loss, current ripple, total harmonic distortion, and also the voltage spike on the switching devices. In order to select the best PWM sequence to obtain the best performance and efficiency, A complete analysis and calculation for the four mentioned criterions are presented for different sequences. For each criterion, the best sequences are selected to obtain better performance. Finally, the optimized PWM sequence in the modified SVPWM control for this circuit is selected with the optimized hardware design together to achieve the best efficiency at full operation range. The optimized hardware design has been built in the lab, including the optimal design of the coupled inductor, optimal design and selection of Z-source capacitors and output capacitors, the selection of Z-source diode, and the final layout of the hardware. In order to bring the prototype into real application in hybrid electrical vehicle[3], the inverter efficiency is measured according to the motor P-V curve. The estimated efficiency curve and experiment results are plot and compared. The best efficiency at 15kW reaches 97.6% at unity voltage gain.
It Does Matter How You Normalise the Branch Distance in Search Based Software Testing

The use of search algorithms for test data generation has seen many successful results. For structural criteria such as branch coverage, heuristics have been designed to help the search. The most common heuristic is the use of approach level (usually represented with an integer) to reward test cases whose executions get close (in the control flow graph)to the target branch. To solve the constraints of the predicates in the control flow graph, the branch distance is commonly employed. These two measures are linearly combined. Because the approach level is more important, the branch distance is normalised, often in the range [0,1]. In this paper, we analyse different types of normalising functions. We found out that the one that is usually employed in the literature has several flaws. We hence propose a different normalizing function that is very simple and that does not suffer of these limitations. We carried out empirical and analytical analyses to compare these two functions. In particular, we studied their effect on two commonly used search algorithms, namely Simulated Annealing and Genetic Algorithms.
The Yeast v-SNARE Vti1p Mediates Two Vesicle Transport Pathways through Interactions with the t-SNAREs Sed5p and Pep12p

Membrane traffic in eukaryotic cells requires that specific v-SNAREs on transport vesicles interact with specific t-SNAREs on target membranes. We identified a novel Saccharomyces cerevisiae v-SNARE (Vti1p) encoded by the essential gene, VTI1. Vti1p interacts with the prevacuolar t-SNARE Pep12p to direct Golgi to prevacuolar traffic. vti1-1 mutant cells missorted and secreted the soluble vacuolar hydrolase carboxypeptidase Y (CPY) rapidly and reversibly when vti1-1 cells were shifted to the restrictive temperature. However, overexpression of Pep12p suppressed the CPY secretion defect exhibited by vti1-1 cells at 36°C. Characterization of a second vti1 mutant, vti1-11, revealed that Vti1p also plays a role in membrane traffic at a cis-Golgi stage. vti1-11 mutant cells displayed a growth defect and accumulated the ER and early Golgi forms of both CPY and the secreted protein invertase at the nonpermissive temperature. Overexpression of the yeast cis-Golgi t-SNARE Sed5p suppressed the accumulation of the ER form of CPY but did not lead to CPY transport to the vacuole in vti1-11 cells. Overexpression of Sed5p allowed growth in the absence of Vti1p. In vitro binding and coimmunoprecipitation studies revealed that Vti1p interacts directly with the two t-SNAREs, Sed5p and Pep12p. These data suggest that Vti1p plays a role in cis-Golgi membrane traffic, which is essential for yeast viability, and a nonessential role in the fusion of Golgi-derived vesicles with the prevacuolar compartment. Therefore, a single v-SNARE can interact functionally with two different t-SNAREs in directing membrane traffic in yeast.
RELATIONSHIP BETWEEN PERCEIVED LEARNING STYLE AND TEACHING STYLE OF JUNIOR COLLEGE EDUCATORS

This study examined the relationship of perceptual learning style and teaching style of 138 junior college educators. The Perceptual Learning Style Inventory developed by James and Galbraith (1984) was used to determine learning style preference. The authors modified the inventory to assess preferred teaching style. The Spearman's rho procedure was employed to determine if a correlation existed for the entire group of educators and for each subgroup by major teaching area, sex, years of teaching experience, and by educational attainment. A high correlation existed for all variables except in three subgroup variables. Findings indicate that junior college educators tend to teach the way they prefer to learn. Implications for practice are provided that encourage educators to examine the teaching/learning process in an effort to make it a more effective and rewarding experience for instructors and learners
Contrast analysis of uniformity of simulation signal based on sequence of fuzzy numbers

The uniformity level of simulation signal is expressed as a fuzzy number by using the fitting method, and its contrast analysis is naturally ascribed to the sequence of fuzzy numbers. Considering the influence of information quantity upon sequence of fuzzy numbers, a sequencing method which ponders the generalized average value, deviation, and information quantity of fuzzy number comprehensively is proposed. Then, a contrast analysis method of uniformity of simulation signal based on the sequence of fuzzy numbers is presented. It is shown by the application of the method in simulation system of target acoustic signal that, the analysis result can provide auxiliary decision-making support for the adjustment and test of signal simulation system.
Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells

The androgen receptor (AR) is expressed ubiquitously and plays a variety of roles in a vast number of physiological and pathophysiological processes. Recent studies of AR knockout (ARKO) mouse models, particularly the cell type- or tissue-specific ARKO models, have uncovered many AR cell type- or tissue-specific pathophysiological roles in mice, which otherwise would not be delineated from conventional castration and androgen insensitivity syndrome studies. Thus, the AR in various specific cell types plays pivotal roles in production and maturation of immune cells, bone mineralization, and muscle growth. In metabolism, the ARs in brain, particularly in the hypothalamus, and the liver appear to participate in regulation of insulin sensitivity and glucose homeostasis. The AR also plays key roles in cutaneous wound healing and cardiovascular diseases, including atherosclerosis and abdominal aortic aneurysm. This article will discuss the results obtained from the total, cell type-, or tissue-specific ARKO models. The understanding of AR cell type- or tissue-specific physiological and pathophysiological roles using these in vivo mouse models will provide useful information in uncovering AR roles in humans and eventually help us to develop better therapies via targeting the AR or its downstream signaling molecules to combat androgens/AR-related diseases.
Unsettling the gender binary: experiences of gender in entrepreneurial leadership and implications for HRD

Purpose – This feminist standpoint study aims to make an empirical contribution to the entrepreneurial leadership and HRD fields. Women entrepreneur leaders' experiences of gender will be explored through a framework of doing gender well and doing gender differently to unsettle the gender binary.Design/methodology/approach – Against a backcloth of patriarchy, a theoretical gender lens is developed and a feminist standpoint research (FSR) approach taken in this study. There are five case studies of women entrepreneur leaders operating small businesses across North East England in sectors of IT, law, construction, beauty, and childcare. In each case study a two‐stage semi‐structured interview process was implemented and the women's voices analysed through a framework of doing gender well and differently.Findings – This paper highlights the complexities of gender experiences offering four themes of women entrepreneurs' experiences of gender within entrepreneurial leadership: struggling with entrepreneurial l.
Quantifying topological invariants of neuronal morphologies

Nervous systems are characterized by neurons displaying a diversity of morphological shapes. Traditionally, different shapes have been qualitatively described based on visual inspection and quantitatively described based on morphometric parameters. Neither process provides a solid foundation for categorizing the various morphologies, a problem that is important in many fields. We propose a stable topological measure as a standardized descriptor for any tree-like morphology, which encodes its skeletal branching anatomy. More specifically it is a barcode of the branching tree as determined by a spherical filtration centered at the root or neuronal soma. This Topological Morphology Descriptor (TMD) allows for the discrimination of groups of random and neuronal trees at linear computational cost.
Employee and customer perceptions of service in banks: Replication and extension.

Abstract : Survey data from 142 employees and 968 customers from 28 branches of a bank were analyzed with the following results: (1) Moderate support was found for previous work on correlates of role stress for boundary role employees and good support was found for relationships between branch employees' and branch customers' service perceptions and attitudes; (2) Some significant relationships were reported between branch employees' perceptions of organizational human resources practices and branch customers' attitudes about service; and (3) employee attitudes and customer attitudes were related to their own and one another's turnover intentions. Results were discussed from the perspective of promoting an integration of consumer and organizational behavior in the service sector.