Miracle-dz/UniFAR-FTUs huggingface dataset:
An Interdomain KCNH2 Mutation Produces an Intermediate Long QT Syndrome

Hereditary long QT syndrome is caused by deleterious mutation in one of several genetic loci, including locus LQT2 that contains the KCNH2 gene (or hERG, human ether‐a‐go‐go related gene), causing faulty cardiac repolarization. Here, we describe and characterize a novel mutation, p.Asp219Val in the hERG channel, identified in an 11‐year‐old male with syncope and prolonged QT interval. Genetic sequencing showed a nonsynonymous variation in KCNH2 (c.656A>T: amino acid p.Asp219Val). p.Asp219Val resides in a region of the channel predicted to be unstructured and flexible, located between the PAS (Per‐Arnt‐Sim) domain and its interaction sites in the transmembrane domain. The p.Asp219Val hERG channel produced K+ current that activated with modest changes in voltage dependence. Mutant channels were also slower to inactivate, recovered from inactivation more readily and demonstrated a significantly accelerated deactivation rate compared with the slow deactivation of wild‐type channels. The intermediate nature of the biophysical perturbation is consistent with the degree of severity in the clinical phenotype. The findings of this study demonstrate a previously unknown role of the proximal N‐terminus in deactivation and support the hypothesis that the proximal N‐terminal domain is essential in maintaining slow hERG deactivation.
Exploring the Intention-Behavior Relationship in the Prediction of Sexual Risk Behaviors: Can It Be Strengthened?

Many theoretical models examining health risk behaviors, such as sexual risk taking, assume intentions directly predict behavior, and intentions are sometimes measured as a proxy for behavior. Given that there is often a discrepancy between intentions and behaviors (e.g., Sheeran, 2002), this study addressed factors that predict intention–behavior congruence. Specifically, utilizing a prospective design, the goal of the study was to determine if characteristics of university students' last sexual encounter predicted whether those students who intended to use condoms, contraception, or dual methods did so in their last sexual encounter with both relationship and casual partners. The seven tested variables were condom planning and preparatory behaviors, mood, sexual arousal, substance use, perceived partner attractiveness, intention certainty, and intention stability. Data were collected from 520 American undergraduate students at a medium-sized university. The six discriminant function analyses examining the intention–behavior relationship were able to correctly classify between 74% and 92% of the participants concerning whether intenders engaged in safe sex behaviors. The variables that best discriminated between behavior engagement over the six analyses were intention stability, intention certainty, and engagement in condom preparatory behaviors. The implications of these results for sexual risk prevention and intervention research are discussed.
Whittaker models and the integral Bernstein center for GL_n

We establish integral analogues of results of Bushnell and Henniart for spaces of Whittaker functions arising from the groups GL_n(F) for F a p-adic field. We apply the resulting theory to the existence of representations arising from the conjectural "local Langlands correspondence in families" of Emerton-Helm, and reduce the question of the existence of such representations to a natural conjecture relating the integral Bernstein center of GL_n(F) to the deformation theory of Galois representations.
Transformative reality: Augmented reality for visual prostheses

Visual prostheses such as retinal implants provide bionic vision that is limited in spatial and intensity resolution. This limitation is a fundamental challenge of bionic vision as it severely truncates salient visual information. We propose to address this challenge by performing real time transformations of visual and non-visual sensor data into symbolic representations that are then rendered as low resolution vision; a concept we call Transformative Reality. For example, a depth camera allows the detection of empty ground in cluttered environments that is then visually rendered as bionic vision to enable indoor navigation. Such symbolic representations are similar to virtual content overlays used in Augmented Reality but are registered to the 3D world via the user's sense of touch. Preliminary user trials, where a head mounted display artificially constrains vision to a 25×25 grid of binary dots, suggest that Transformative Reality provides practical and significant improvements over traditional bionic vision in tasks such as indoor navigation, object localisation and people detection.
Fast Lattice Point Enumeration with Minimal Overhead

Enumeration algorithms are the best currently known methods to solve lattice problems, both in theory (within the class of polynomial space algorithms), and in practice (where they are routinely used to evaluate the concrete security of lattice cryptography). However, there is an uncomfortable gap between our theoretical understanding and practical performance of lattice point enumeration algorithms. The algorithms typically used in practice have worst-case asymptotic running time 2O(n2), but perform extremely well in practice, at least for all values of the lattice dimension for which experimentation is feasible. At the same time, theoretical algorithms (Kannan, Mathematics of Operation Research 12(3):415-440, 1987) are asymptotically superior (achieving 2O(n log n) running time), but they are never used in practice because they incur a substantial overhead that makes them uncompetitive for all reasonable values of the lattice dimension n. This gap is especially troublesome when algorithms are run in practice to evaluate the concrete security of a cryptosystem, and then experimental results are extrapolated to much larger dimension where solving lattice problems is computationally infeasible. We introduce a new class of (polynomial space) lattice enumeration algorithms that simultaneously achieve asymptotic efficiency (meeting the theoretical nO(n) = 2O(n log n) time bound) and practicality, matching or surpassing the performance of practical algorithms already in moderately low dimension. Key technical contributions that allow us to achieve this result are a new analysis technique that allows us to greatly reduce the number of recursive calls performed during preprocessing (from super exponential in n to single exponential, or even polynomial in n), a new enumeration technique that can be directly applied to projected lattice (basis) vectors, without the need to remove linear dependencies, and a modified block basis reduction method with fast (logarithmic) convergence properties. The last technique is used to obtain a new SVP enumeration procedure with O(nn/2e) running time, matching (even in the constant in the exponent) the optimal worst-case analysis (Hanrot and Stehle, CRYPTO 2007) of Kannan's theoretical algorithm, but with far superior performance in practice. We complement our theoretical analysis with a preliminary set of experiments that not only support our practicality claims, but also allow to estimate the crossover point between different versions of enumeration algorithms, as well as asymptotically faster (but not quite practical) algorithms running in single exponential 2O(n) time and space.
Selective Attention Warps Spatial Representation

Selective attention not only influences which objects in a display are perceived, but also directly changes the character of how they are perceived—for example, making attended objects appear larger or sharper. In studies of multiple-object tracking and probe detection, we explored the influence of sustained selective attention on where objects are seen to be in relation to each other in dynamic multi-object displays. Surprisingly, we found that sustained attention can warp the representation of space in a way that is object-specific: In immediate recall of the positions of objects that have just disappeared, space between targets is compressed, whereas space between distractors is expanded. These effects suggest that sustained attention can warp spatial representation in unexpected ways.
Nature of global large‐scale sea level variability in relation to atmospheric forcing: A modeling study

The relation between large-scale sea level variability and ocean circulation is studied using a numerical model. A global primitive equation model of the ocean is forced by daily winds and climatological heat fluxes corresponding to the period from January 1992 to January 1994. The physical nature of sea level's temporal variability from periods of days to a year is examined on the basis of spectral analyses of model results and comparisons with satellite altimetry and tide gauge measurements. The study elucidates and diagnoses the inhomogeneous physics of sea level change in space and frequency domain. At midlatitudes, large-scale sea level variability is primarily due to steric changes associated with the seasonal heating and cooling cycle of the surface layer. In comparison, changes in the tropics and high latitudes are mainly wind driven. Wind-driven variability exhibits a strong latitudinal dependence in itself. Wind-driven changes are largely baroclinic in the tropics but barotropic at higher latitudes. Baroclinic changes are dominated by the annual harmonic of the first baroclinic mode and is largest off the equator; variabilities associated with equatorial waves are smaller in comparison. Wind-driven barotropic changes exhibit a notable enhancement over several abyssal plains in the Southern Ocean, which is likely due to resonant planetary wave modes in basins semienclosed by discontinuities in potential vorticity. Otherwise, barotropic sea level changes are typically dominated by high frequencies with as much as half the total variance in periods shorter than 20 days, reflecting the frequency spectra of wind stress curl. Implications of the findings with regards to analyzing observations and data assimilation are discussed.
Exceptionally mild reactive stripping of native ligands from nanocrystal surfaces by using Meerwein's salt.

Native coordinating ligands acquired during the chemical synthesis of colloidal nanocrystals are optimized primarily for their ability to exert control over nanocrystal size, composition, morphology, and dispersibility, and not necessarily for their final application. [1] In general, they are hydrophobic and highly insulating, and constitute a significant barrier for charge or ion transport in devices configured therefrom. Bare nanocrystal surfaces, while desirable for many applications, can be difficult to obtain reliably and without undesirable consequences. For example, removal of native ligands from nanocrystal dispersions usually results in aggregation or etching, [2] while in thin films their chemical displacement (e.g., by hydrazine or formic acid) often gives inefficient removal of surface ligands. [3] Thermal treatments inevitably leave behind an undesirable residue, require lengthy annealing times, or result in particle sintering. [4] Nevertheless, these approaches have demonstrated that near-bare nanocrystal surfaces are useful in a broad spectrum of advanced energy applications, from light-emitting diodes to field-effect transistors and photovoltaics. [5, 6] Dispersions of bare nanocrystals would also be useful as nanoinks and for facilitating their transfer into polar media for biomedical applications and catalysis. [7] In pursuit of a universal reagent for producing
Temporal modifications in bone following spinal cord injury in rats

Introduction The aim of this study was to investigate the temporal modifications in bone mass, bone biomechanical properties and bone morphology in spinal cord injured rats 2, 4 and 6 weeks after a transection. Material and methods Control animals were randomly distributed into four groups (n = 10 each group): control group (CG) – control animals sacrificed immediately after surgery; spinal cord-injured 2 weeks (2W) – spinal cord-injured animals sacrificed 2 weeks after surgery; spinal cord-injured 4 weeks (4W) – spinal cord-injured animals sacrificed 4 weeks after surgery; spinal cord-injured 6 weeks (6W) – spinal cord-injured animals sacrificed 6 weeks after surgery. Results Biomechanical properties of the right tibia were determined by a three-point bending test and injured animals showed a statistically significant decrease in maximal load compared to control animals. The right femur was used for densitometric analysis and bone mineral content of the animals sacrificed 4 and 6 weeks after surgery was significantly higher compared to the control animals and animals sacrificed 2 weeks after surgery. Histopathological and morphological analysis of tibiae revealed intense resorptive areas in the group 2 weeks after injury only. Conclusions The results of this study show that this rat model is a valuable tool to investigate bone remodeling processes specifically associated with SCI. Taken together, our results suggest that spinal cord injury induced bone loss within 2 weeks after injury in rats.
Growth factors modify the epidermal growth factor receptor through multiple pathways

Previous results have shown that tumor promoters modify the properties of the epidermal growth factor (EGF) receptor through the activation of protein kinase C. Diacylglycerol‐generating factors such as platelet‐derived growth factor (PDGF) and p28sis should activate protein kinase C and alter EGF receptor properties in a similar manner. To test directly the involvement of protein kinase C in the action of media from v‐sis‐transformed cells on the EGF receptor, Swiss 3T3 cells were first extensively treated with various concentrations of the tumor‐promoter phorbol dibutyrate (PDBu) This treatment reduced levels of active protein kinase C in the cells, making them less responsive to subsequent rechallenge with the tumor promoter. The results demonstrate that there are at least two components to the action of media from v‐sis transformed cells on EGF binding: a labile factor that confers protein kinase C independence and a stable factor that appears to be dependent on protein kinase C. The action of the first factor cannot be mimicked by transforming growth factor‐β or EGF in either the presence or absence of PDGF. The action of the second factor is similar to that of PDGF. These findings indicate that heterologous regulation of the EGF receptor can occur through both protein kinase C‐dependent and ‐independent pathways.
Utility-driven anonymization in data publishing

Privacy-preserving data publication has been studied intensely in the past years. Still, all existing approaches transform data values by random perturbation or generalization. In this paper, we introduce a radically different data anonymization methodology. Our proposal aims to maintain a certain amount of patterns, defined in terms of a set of properties of interest that hold for the original data. Such properties are represented as linear relationships among data points. We present an algorithm that generates a set of anonymized data that strictly preserves these properties, thus maintaining specified patterns in the data. Extensive experiments with real and synthetic data show that our algorithm is efficient, and produces anonymized data that affords high utility in several data analysis tasks while safeguarding privacy.
A new era! ? collaborative geological and geophysical mapping

A core function of the New South Wales Department of Mineral Resources is the ongoing geological mapping of the State of New South Wales. Until recently, airborne geophysical data were not used in field mapping. Now that Second Edition geological mapping has begun, and with assistance from the National Geoscience Mapping Accord, large areas of the State have been flown with high resolution airborne geophysical surveys. With the State Government now requiring more to be done with less, the integration of these airborne datasets with geology in a collaborative process is necessary to maximise efficiency of geological mapping. Integration is achieved by initially using standard data presentations in a pre-mapping interpretation, followed by a suite of data enhancements during the field mapping phase. On-going interpretation is further refined by the use of ground geophysics and potential field modelling to resolve specific problems. Post-mapping synthesis of the data in a GIS environment enables mismatch between datasets to be highlighted. The end result is more professionally produced, high quality geological maps.
The Study of Adolescents Worries and Wishes in the North of Fars ProvinceThe Study of Adolescents Worries and Wishes in the North of Fars Province

The worries & wishes of 14 -19 years-old adolescents of Abadeh, Bavanat & Khorambid cities in the north of Fars province are investigated in this research. The wishes & worries are measured by wishes measurement scale (WMS) and Ahwaz worry inventory (AWI) respectively. The Ss consisted of 300 Adolescents (150 girls & 150 Boys) that selected by ratio sampling method. The most important results of project are as following :( 1) there are significant positive correlations between wishes & worries. (2) Girls in comparison with boys have been significantly higher on emotional-psychological and moral-philosophical wishes. Further more, they haven't been different on somatic- physical & social - familial wishes. (3) In self -esteem, vocational, other relations, insecurity, detail problems worries and AWI, girls have been significantly worrier than boys. While in cognitive & future worry factors their situation have not been different. (4). According to the influence of gender on adolescents, worries and wishes for prompting of their mental health should be used in different ways.
Scholarly Digital Libraries as a Platform for Malware Distribution

Researchers from academic institutions and the corporate sector rely heavily on scholarly digital libraries for accessing journal articles and conference proceedings. Primarily downloaded in the form of PDF files, there is a risk that these documents may be compromised by attackers. PDF files have many capabilities that have been widely used for malicious operations. Attackers increasingly take advantage of innocent users who open PDF files with little or no concern, mistakenly considering these files safe and relatively non-threatening. Researchers also consider scholarly digital libraries reliable and home to a trusted corpus of papers and untainted by malicious files. For these reasons, scholarly digital libraries are an attractive target for cyber-attacks launched via PDF files. In this study, we present several vulnerabilities and practical distribution attack approaches tailored for scholarly digital libraries. To support our claim regarding the attractiveness of scholarly digital libraries as an attack platform, we evaluated more than two million scholarly papers in the CiteSeerX library that were collected over 8 years and found it to be contaminated with a surprisingly large number (0.3%-2%) of malicious scholarly PDF documents, the origin of which is 46 different countries spread worldwide. More than 55% of the malicious papers in CiteSeerX were crawled from IP’s belonging to USA universities, followed by those belonging to Europe (33.6%). We show how existing scholarly digital libraries can be easily leveraged as a distribution platform both for a targeted attack and in a worldwide manner. On average, a certain malicious paper caused high impact damage as it was downloaded 167 times in 5 years by researchers from different countries worldwide. In general, the USA and Asia downloaded the most malicious scholarly papers, 40.15% and 27.9%, respectively. The top malicious scholarly document downloaded is a malicious version of a popular paper in the computer forensics domain, with 2213 downloads in a worldwide coverage of 108 different countries. Finally, we suggest several concrete solutions for mitigating such attacks, including simple deterministic solutions and also advanced machine learning-based frameworks.
Decreasing or Non-decreasing Allocation of Dry Matter to Fruit in Japanese Tomato Cultivars in Spite of the Increase in Total Dry Matter of Plants by CO2 Elevation and Fogging

To investigate the mechanism of yield increase by elevated carbon dioxide (CO2) and fogging in Japanese tomato cultivars (Solanum lycopersicum), total above-ground dry matter (TDM), fraction of dry matter distribution to fruit (FDF), and photosynthetic characteristics were measured in 3 Japanese cultivars grown in elevated CO2 with fogging and ambient CO2 without fogging. Fresh fruit yield and TDM were improved by the elevated CO2 and fogging in the 3 Japanese cultivars. Light use efficiency (LUE) was also increased by the elevated CO2 and fogging. No significant decrease in FDF was observed by the elevated CO2 and fogging in 2 Japanese cultivars, ‘Asabiyori 10’ and ‘Junkei Aichi Fast’. Thus, the increase in TDM by higher LUE contributed directly to the yield increase in these 2 cultivars. However, FDF in ‘Momotaro York’ was decreased significantly by the elevated CO2 and fogging. Thereby, the yield increase by the elevated CO2 and fogging was diminished in ‘Momotaro York’ in spite of the increase in TDM. The number of trusses having immature fruit in ‘Momotaro York’ under elevated CO2 and fogging was significantly higher than those of the others, although no increase in the number of trusses having immature fruit was observed in the other 2 cultivars. Although vegetative growth characteristics such as leaf area, LAI, and fresh and dry weights of leaves and stem were increased by the elevated CO2 and fogging, no negative effects such as a change in lightextinction coefficient and a decrease in maximum photosynthetic rate were observed. The elevated CO2 and fogging increased the number of harvested fruit but decreased weight per fruit, namely, fruit size, in the 3 cultivars.
A hybridized genetic parallel programming based logic circuit synthesizer

Genetic Parallel Programming (GPP) is a novel Genetic Programming paradigm. Based on the GPP paradigm and a local search operator - FlowMap, a logic circuit synthesizing system integrating GPP and FlowMap, a Hybridized GPP based Logic Circuit Synthesizer (HGPPLCS) is developed. To show the effectiveness of the proposed HGPPLCS, six combinational logic circuit problems are used for evaluations. Each problem is run for 50 times. Experimental results show that both the lookup table counts and the propagation gate delays of the circuits collected are better than those obtained by conventional design or evolved by GPP alone. For example, in a 6-bit one counter experiment, we obtained combinational digital circuits with 8 four-input lookup tables in 2 gate level on average. It utilizes 2 lookup tables and 3 gate levels less than circuits evolved by GPP alone.
Experience, adjustment, and engagement: the role of video in law enforcement

Questions about the effectiveness of increasingly ubiquitous video technology in law enforcement have prompted an examination of the practices surrounding this technology. We present the results of a multi-site study aimed at understanding the use of video in several phases of law enforcement, from crime prevention and response to investigation and prosecution. Our findings show that while video has provided numerous benefits to law enforcement agencies, in many cases the technology either fails to support key facets of work or introduces new tasks that present an additional burden to workers. We discuss the need to incorporate human experience and tacit knowledge, operator engagement, and the greater ecosystem of work into video deployments.