Miracle-dz/UniFAR-FTUs huggingface dataset:
A Visual-Attention Model Using Earth Mover's Distance-Based Saliency Measurement and Nonlinear Feature Combination

This paper introduces a new computational visual-attention model for static and dynamic saliency maps. First, we use the Earth Mover's Distance (EMD) to measure the center-surround difference in the receptive field, instead of using the Difference-of-Gaussian filter that is widely used in many previous visual-attention models. Second, we propose to take two steps of biologically inspired nonlinear operations for combining different features: combining subsets of basic features into a set of super features using the Lm-norm and then combining the super features using the Winner-Take-All mechanism. Third, we extend the proposed model to construct dynamic saliency maps from videos by using EMD for computing the center-surround difference in the spatiotemporal receptive field. We evaluate the performance of the proposed model on both static image data and video data. Comparison results show that the proposed model outperforms several existing models under a unified evaluation setting.
Phase structure development as preheating UHMWPE powder temperature changes in the micro-UPM process

In this study, using high-speed mechanical drilling on printed circuit boards (PCBs) with two micro carbide drill bits with diameters of 0.15 mm and 0.20 mm, two different PCB micro-cylinder array inserts are fabricated using the micro-ultrasonic powder moulding (micro-UPM) process. According to the temperature curves recorded by a measurement module, when viscoelastic heating dominated, the temperature increasing rate was about three times the rate when interfacial friction heating dominated. From the differential scanning calorimetry and nanoindentation test results, if the ultra-high molecule weight polyethylene (UHMWPE) powder was not preheated, then the micro-cylinder array polymer parts generally consisted of nascent and melt-recrystallised phases as a whole. However, when the micro-cavity and compressed UHMWPE powder grew from room temperature of 28 °C to 85 °C, the two-phase structure gradually developed into a single melt-recrystallised phase. According to single-crystal x-ray diffraction test results, the crystallinity of the base region of the micro-UPM cylinder array part is higher than that of the micro-cylinder region, whereas the grain size of the (1 1 0) crystal surface is larger than that of the (2 0 0) crystal surface.
Osteoprotegerin Is Associated With Major Bleeding But Not With Cardiovascular Outcomes in Patients With Acute Coronary Syndromes: Insights From the PLATO (Platelet Inhibition and Patient Outcomes) Trial

Background Elevated levels of osteoprotegerin, a secreted tumor necrosis factor–related molecule, might be associated with adverse outcomes in patients with coronary artery disease. We measured plasma osteoprotegerin concentrations on hospital admission, at discharge, and at 1 and 6 months after discharge in a predefined subset (n=5135) of patients with acute coronary syndromes in the PLATO (Platelet Inhibition and Patient Outcomes) trial. Methods and Results The associations between osteoprotegerin and the composite end point of cardiovascular death, nonprocedural spontaneous myocardial infarction or stroke, and non–coronary artery bypass grafting major bleeding during 1 year of follow‐up were assessed by Cox proportional hazards models. Event rates of the composite end point per increasing quartile groups at baseline were 5.2%, 7.5%, 9.2%, and 11.9%. A 50% increase in osteoprotegerin level was associated with a hazard ratio (HR) of 1.31 (95% confidence interval [CI], 1.21–1.42) for the composite end point but was not significant in adjusted analysis (ie, clinical characteristics and levels of C‐reactive protein, troponin T, NT‐proBNP [N‐terminal pro‐B‐type natriuretic peptide], and growth differentiation factor‐15). The corresponding rates of non–coronary artery bypass grafting major bleeding were 2.4%, 2.2%, 3.8%, and 7.2%, with an unadjusted HR of 1.52 (95% CI, 1.36–1.69), and a fully adjusted HR of 1.26 (95% CI, 1.09–1.46). The multivariable association between the osteoprotegerin concentrations and the primary end point after 1 month resulted in an HR of 1.09 (95% CI, 0.89–1.33); for major bleeding after 1 month, the HR was 1.33 (95% CI, 0.91–1.96). Conclusions In patients with acute coronary syndrome treated with dual antiplatelet therapy, osteoprotegerin was an independent marker of major bleeding but not of ischemic cardiovascular events. Thus, high osteoprotegerin levels may be useful in increasing awareness of increased bleeding risk in patients with acute coronary syndrome receiving antithrombotic therapy. Clinical Trial Registration URL: http://www.clinicaltrials. gov. Unique identifier: NCT00391872.
Establishment and Evaluation of a Stable Cattle Type II Alveolar Epithelial Cell Line

Macrophages and dendritic cells are recognized as key players in the defense against mycobacterial infection. Recent research has confirmed that alveolar epithelial cells (AECs) also play important roles against mycobacterium infections. Thus, establishing a stable cattle AEC line for future endogenous immune research on bacterial invasion is necessary. In the present study, we first purified and immortalized type II AECs (AEC II cells) by transfecting them with a plasmid containing the human telomerase reverse trancriptase gene. We then tested whether or not the immortalized cells retained the basic physiological properties of primary AECs by reverse-transcription polymerase chain reaction and Western blot. Finally, we tested the secretion capacity of immortalized AEC II cells upon stimulation by bacterial invasion. The cattle type II alveolar epithelial cell line (HTERT-AEC II) that we established retained lung epithelial cell characteristics: the cells were positive for surfactants A and B, and they secreted tumor necrosis factor-α and interleukin-6 in response to bacterial invasion. Thus, the cell line we established is a potential tool for research on the relationship between AECs and Mycobacterium tuberculosis.
Ground plane feature detection in mobile vision-aided inertial navigation

In this paper, a method for determining ground plane features in a sequence of images captured by a mobile camera is presented. The hardware of the mobile system consists of a monocular camera that is mounted on an inertial measurement unit (IMU). An image processing procedure is proposed, first to extract image features and match them across consecutive image frames, and second to detect the ground plane features using a two-step algorithm. In the first step, the planar homography of the ground plane is constructed using an IMU-camera motion estimation approach. The obtained homography constraints are used to detect the most likely ground features in the sequence of images. To reject the remaining outliers, as the second step, a new plane normal vector computation approach is proposed. To obtain the normal vector of the ground plane, only three pairs of corresponding features are used for a general camera transformation. The normal-based computation approach generalizes the existing methods that are developed for specific camera transformations. Experimental results on real data validate the reliability of the proposed method.
Fast optimized smooth handoff (FOSH)

The Mobile IP protocol and its extension optimized smooth handoff are significantly detrimental to quality requirements of real-time applications. In this paper we propose and discuss FOSH (fast optimized smooth handoff), a procedure aiming at extending the improvements introduced by optimized smooth handoff to obtain an efficient scheme for the transmission of real-time traffic in scenarios where frequent handoffs are likely. The basic idea of FOSH is to provide the foreign agent with a neighbours cache allowing it to store the IP addresses of its adjacent foreign agents. Using such cache, the foreign agent can advertise to mobile nodes in its wireless network mobility services offered from adjacent foreign agents. This mechanism is provided in addition to the conventional advertising in order to give the MN a description of the surrounding environment. Specifically, the mobile node is able to send the registration message in advance. Simulations are presented to show the efficiency of the proposed scheme.
Influence of Currents from Electrostatic Charges on WEC Formation in Rolling Bearings

ABSTRACT White etching crack (WEC) early bearing failures occur when the rolling contact is subjected to a so-called additional load such as an electrical current flowing through the bearing, in addition to the pure rolling load (pHz). Tests on rolling bearings showed that a low electrical direct current flow, such as that resulting from electrostatic charges, can lead to WEC failures in oil-lubricated roller bearings and greased ball bearings. The WEC formation in the performed tests was dependent on the current, electrical polarity, load type (rotating or stationary ring load), and bearing load. A black oxidation of the WEC critical bearing ring led to a significant increase in lifetime. Based on the findings, the failure hypothesis “cathodic WEC fatigue” for electrical direct current-initiated WEC failures was established.
Adaptive Co-Weighting Deep Convolutional Features for Object Retrieval

Aggregating deep convolutional features into a global image vector has attracted sustained attention in image retrieval. In this paper, we propose an efficient unsupervised aggregation method that uses an adaptive Gaussian filter and an element-value sensitive vector to co-weight deep features. Specifically, the Gaussian filter assigns large weights to features of region-of-interests (RoI) by adaptively determining the RoI's center, while the element-value sensitive channel vector suppresses burstiness phenomenon by assigning small weights to feature maps with large sum values of all locations. Experimental results on benchmark datasets validate the proposed two weighting schemes both effectively improve the discrimination power of image vectors. Furthermore, with the same experimental setting, our method outperforms other very recent aggregation approaches by a considerable margin.
Stomach-brain synchrony reveals a novel, delayed-connectivity resting-state network in humans

Resting-state networks offer a unique window into the brain’s functional architecture, but their characterization remains limited to instantaneous connectivity thus far. Here, we describe a novel resting-state network based on the delayed connectivity between the brain and the slow electrical rhythm (0.05 Hz) generated in the stomach. The gastric network cuts across classical resting-state networks with partial overlap with autonomic regulation areas. This network is composed of regions with convergent functional properties involved in mapping bodily space through touch, action or vision, as well as mapping external space in bodily coordinates. The network is characterized by a precise temporal sequence of activations within a gastric cycle, beginning with somato-motor cortices and ending with the extrastriate body area and dorsal precuneus. Our results demonstrate that canonical resting-state networks based on instantaneous connectivity represent only one of the possible partitions of the brain into coherent networks based on temporal dynamics.
Kinesin motility is driven by subdomain dynamics

The microtubule (MT)-associated motor protein kinesin utilizes its conserved ATPase head to achieve diverse motility characteristics. Despite considerable knowledge about how its ATPase activity and MT binding are coupled to the motility cycle, the atomic mechanism of the core events remain to be found. To obtain insights into the mechanism, we performed 38.5 microseconds of all-atom molecular dynamics simulations of kinesin-MT complexes in different nucleotide states. Local subdomain dynamics were found to be essential for nucleotide processing. Catalytic water molecules are dynamically organized by the switch domains of the nucleotide binding pocket while ATP is torsionally strained. Hydrolysis products are 'pulled' by switch-I, and a new ATP is 'captured' by a concerted motion of the α0/L5/switch-I trio. The dynamic and wet kinesin-MT interface is tuned for rapid interactions while maintaining specificity. The proposed mechanism provides the flexibility necessary for walking in the crowded cellular environment.
Variation on Molecular Structure, Crystallinity, and Optical Properties of Dentin Due to Nd:YAG Laser and Fluoride Aimed at Tooth Erosion Prevention

This in vitro study evaluated the compositional, crystalline, and morphological effects promoted by Nd:YAG laser on root dentin, and verified the effects of laser and topical acidulated phosphate fluoride application (APF-gel) on dentin erosion. 180 bovine dentin slabs were randomized into 4 groups (n = 45): G1–untreated, G2–APF-gel (1.23% F−, 4 min), G3–Nd:YAG (1064 nm, 84.9 J/cm2, 10 Hz), and G4–APF-gel application followed by Nd:YAG laser irradiation. The compositional, crystalline, and morphological effects promoted by treatments were investigated on five samples of each experimental group. The other samples were submitted to a 5-day, 10-day, or 15-day erosive and abrasive demineralization and remineralization cycling in order to create erosion lesions. The area and depth of lesions, as well as the optical attenuation coefficient, were assessed, and all data were statistically analysed (p < 0.05). Nd:YAG laser promoted the reduction of carbonate, the formation of tetracalcium phosphate, as well as the melting and recrystallization of the dentin surface. Laser significantly decreased the area and depth of erosion lesions and altered the optical attenuation coefficient when compared to untreated and APF-gel groups, but the association of APF-gel and laser did not promote an additional effect. Nd:YAG laser irradiation can be a promissory treatment to prevent dentin erosion and the abrasion process.
High performance wearable two-channel hybrid BCI system with eye closure assist

Generally, eye closure (EC) and eye opening (EO)-based alpha blocking has widely recognized advantages, such as being easy to use, requiring little user training, while motor imagery (MI) is difficult for some users to have concrete feelings. This study presents a hybrid brain-computer interface (BCI) combining MI and EC strategies - such an approach aims to overcome some disadvantages of MI-based BCI, improve the performance and universality of the BCI. The EC/EO is employed to control the machine to switch in different states including forward, stop, changing direction motions, while the MI is used to control the machine to turn left or right for 90° by imagining the hands grasp motions when the system is switched into “changing direction” state. Additionally, a wearable two-channel EEG device is utilized in order to increase the efficiency of EEG processing and improving the practical utility. Results show that proposed hybrid system can generate four control commands with the average accuracy of 87.72%, which is higher than only using MI. Besides, it is possible to reach the same good accuracy using two-channel EEG as with usual multi-channel EEG.
Toxicity research of smouldering and flaming pine timber treated with fire retardant solutions

Abstract The emission of toxic gaseous combustion products from timber constructions influences on the time required for evacuation of people from a building during a fire. In order to prolong the time interval until inflammation of timber constructions, fire retardant solutions are used. It is relevant and very important to determine how the emission of toxic gaseous combustion products from pine timber non-treated and treated with fire retardant solutions used in Lithuania differs during thermal destruction. Measuring carbon monoxide (CO) emissions, the paper focuses on toxicity analysis determined by nonstandard and standard research methods of smouldering and flaming pine timber, both non-treated and treated with fire retardant solutions. The description comprises specimens used in research and their preparation, nonstandard and standard research equipment and methods determining toxicity of smouldering and flaming pine timber, both non-treated and treated with fire retardant solutions. The article pr.
Development of controlled release silicone adhesive-based mupirocin patch demonstrates antibacterial activity on live rat skin against Staphylococcus aureus

Background Peritonitis is the most serious complication of peritoneal dialysis. Staphylococcus aureus infections could lead to peritonitis which causes reversal of peritoneal dialysis treatment back to hemodialysis. The aim of this study was to develop a controlled release silicone adhesive-based mupirocin patch for prophylactic effect and analyze its antibacterial effectiveness against S. aureus. Methods The matrix patches were prepared by using different polymers, with and without silicone adhesive, dibutyl sebacate and mupirocin. The patches were characterized for mechanical properties, drug content, moisture content, water absorption capacity and Fourier transform infrared spectrum. In vitro release studies were performed by using Franz diffusion cell. In vitro disk diffusion assay was performed on the Mueller–Hinton Agar plate to measure the zone of inhibition of the patches. The in vivo study was performed on four groups of rats with bacterial counts at three different time intervals, along with skin irritancy and histopathologic studies. Results The patches showed appropriate average thickness (0.63–1.12 mm), tensile strength (5.08–10.08 MPa) and modulus of elasticity (21.53–42.19 MPa). The drug content ranged from 94.5% to 97.4%, while the moisture content and water absorption capacities at two relative humidities (75% and 93%) were in the range of 1.082–3.139 and 1.287–4.148 wt%, respectively. Fourier transform infrared spectra showed that there were no significant interactions between the polymer and the drug. The highest percentage of drug release at 8 hours was 47.94%. The highest zone of inhibition obtained was 28.3 mm against S. aureus. The in vivo studies showed that the bacterial colonies were fewer at 1 cm (7×101 CFU/mL) than at 2 cm (1.3×102 CFU/mL) over a 24-hour period. The patches were nonirritant to the skin, and histopathologic results also showed no toxic or damaging effects to the skin. Conclusion The in vitro and in vivo studies indicated that controlled release patches reduced the migration of S. aureus on the live rat skin effectively, however, a longer duration of study is required to determine the effectiveness of the patch on a suitable peritonitis-induced animal model.
Clinical significance of nuclear factor erythroid 2-related factor 2 in patients with chronic obstructive pulmonary disease

Background/Aims Several studies have identified a role for nuclear factor erythroid 2-related factor 2 (Nrf2) in the development of chronic obstructive pulmonary disease (COPD). However, the relationship between the plasma Nrf2 level and the extent of systemic inflammation associated with COPD status remains unclear. Methods Patients diagnosed with COPD were recruited from St. Paul’s Hospital, The Catholic University of Korea, between July 2009 and May 2012. Patients were classified into two groups according to the severity of their symptoms on initial presentation, a COPD-stable group (n = 25) and a COPD-exacerbation group (n = 30). Seventeen patients were enrolled as a control group (n = 17). The plasma levels of Nrf2 and other systemic inf lammatory biomarkers, including interleukin 6 (IL-6), surfactant protein D (SP-D), and C-reactive protein (CRP), were measured. We collected clinical data including pulmonary function test results, and analyzed the relationships between the biomarker levels and the clinical parameters. Results Plasma Nrf2 and CRP levels significantly increased in a stepwise manner with an increase in inflammatory status (control vs. COPD-stable vs. COPD-exacerbation) (p = 0.002, p < 0.001). Other biomarkers of systemic inflammation (IL-6, SP-D) exhibited similar tendencies, but significant differences were not apparent. Furthermore, we observed negative correlations between the plasma level of Nrf2 and both the forced expiratory volume in 1 second (FEV1) (r = –0.339, p = 0.015) and the forced expiratory ratio (FEV1/forced vital capacity [FVC]) (r = –0.342, p = 0.014). However, CRP level was not correlated with any measured parameter. Conclusions Plasma Nrf2 levels gradually increased in line with disease severity and the extent of systemic inflammation in patients with COPD.
Loquacious-PD facilitates Drosophila Dicer-2 cleavage through interactions with the helicase domain and dsRNA

Significance Drosophila melanogaster use RNA interference to respond to a viral infection. Dicer-2 cleaves viral double-stranded RNA (dsRNA), producing siRNAs that silence viral gene expression. Dicer-2 recognizes the ends of dsRNA, and this property likely evolved to distinguish between viral and cellular dsRNA. Loquacious-PD (Loqs-PD), a dsRNA binding protein, is not required for Dicer-2’s antiviral activity. However, by allowing Dicer-2 to cleave in a termini-independent manner, Loqs-PD facilitates cleavage of endogenous substrates with more complex termini. Our studies are significant because they provide a mechanistic basis for how Loqs-PD modulates Dicer-2 activity. For example, they reveal a previously unrecognized protein–protein interaction interface on the helicase domain of Dicer-2. Loquacious-PD (Loqs-PD) is required for biogenesis of many endogenous siRNAs in Drosophila. In vitro, Loqs-PD enhances the rate of dsRNA cleavage by Dicer-2 and also enables processing of substrates normally refractory to cleavage. Using purified components, and Loqs-PD truncations, we provide a mechanistic basis for Loqs-PD functions. Our studies indicate that the 22 amino acids at the C terminus of Loqs-PD, including an FDF-like motif, directly interact with the Hel2 subdomain of Dicer-2’s helicase domain. This interaction is RNA-independent, but we find that modulation of Dicer-2 cleavage also requires dsRNA binding by Loqs-PD. Furthermore, while the first dsRNA-binding motif of Loqs-PD is dispensable for enhancing cleavage of optimal substrates, it is essential for enhancing cleavage of suboptimal substrates. Finally, our studies define a previously unrecognized Dicer interaction interface and suggest that Loqs-PD is well positioned to recruit substrates into the helicase domain of Dicer-2.
ANALYSIS WITH MSC ADAMS OF A 5-FINGER AND 3-PHALANX /FINGER UNDER-ACTUATEDMECHANICAL HAND

This paper studies the analysis with MSC ADAMS of a 5-fingered and 3-phalanx/finger underactuated mechanical hand, designed by the author to work on industrial robots. Moreover, in order to increase grasping safety in the automated handling process, the author has fitted each finger with a locking sequence in the final phase of grasping. Thus, the mechanism of mechanical hand is considered to be a mechanical system and is treated like a set of rigid bodies connected by mechanical linkages and elastic elements. To model and simulate this mechanism with MSC ADAMS programme, the author covered the following stages: construction of the model, testing-simulation, validation, finishing, parameterization, and optimization