Miracle-dz/UniFAR-FTUs huggingface dataset:
State reduction in wireless software defined network with LSP multiplexing

Wireless Software Defined Network (W-SDN) is the application of SDN technology in wireless network and has been widely used in sensor network, 5G communication network, et al. Since SDN needs to install flow entries at every hop to match each data packet, then it may bring heavy burden to the wireless nodes as the wireless node usually has much smaller memory space comparing with network devices in wired network and the flow entry matching process may consume too much energy. Therefore, how to reduce the state information, which wireless node stores in form of flow entries, has a great significance to the scalability and practicality of W-SDN. In this paper, we propose a LSP multiplexing method which leverages both the concept of Label Switch Path (LSP) in MPLS technology and source routing mechanism. Through simulations, it can be demonstrated that the method proposed in this paper can effectively reduce the state information that wireless node stores, while achieve a much shorter packet header comparing with the source routing.
Widespread occurrence of a domestic dog mitochondrial DNA haplotype in southeastern US coyotes

Sequence analysis of the mitochondrial DNA control region from 112 southeastern US coyotes (Canis latrans) revealed 12 individuals with a haplotype closely related to those in domestic dogs. Phylogenetic analyses grouped this new haplotype in the dog/grey wolf (Canis familiaris/Canis lupus) clade with 98% bootstrap support. These results demonstrate that a male coyote hybridized with a female dog, and female hybrid offspring successfully integrated into the coyote population. The widespread distribution of this haplotype from Florida to West Virginia suggests that the hybridization event occurred long ago before the southeastern USA was colonized by coyotes. However, it could have occurred in the southeastern USA before the main front of coyotes arrived in the area between male coyotes released for sport and a local domestic dog. The introgression of domestic dog genes into the southeastern coyote population does not appear to have substantially affected the coyote's genetic, morphological, or behavioural integrity. However, our results suggest that, contrary to previous reports, hybridization can occur between domestic and wild canids, even when the latter is relatively abundant. Therefore, hybridization may be a greater threat to the persistence of wild canid populations than previously thought.
Fertility Status of Married Women and Its Determinants in Ethiopia

This study investigates determinant factors of fertility among married women in Ethiopia, the second most populous country in Africa with rapid population growth. The data used for the analysis was obtained from the 2014 Ethiopia Mini Demographic and Health Survey which was carried out by the Central Statistical Agency. A generalized linear model (GLM) analysis was carried out to investigate the effect of socioeconomic and demographic factors on the number of children ever born by a married woman of age 15-49 years. High fertility was independently associated with residing in urban areas, increased household economic status, younger age at first birth and not using contraceptives. Current age and media exposure, household head gender and media exposure, household head gender and regional state, mother’s education and, regional state and media exposure and regional state were found to jointly affect fertility level.
Structuring Decisions for Managing Threatened and Endangered Species in a Changing Climate

The management of endangered species under climate change is a challenging and often controversial task that incorporates input from a variety of different environmental, economic, social, and political interests. Yet many listing and recovery decisions for endangered species unfold on an ad hoc basis without reference to decision‐aiding approaches that can improve the quality of management choices. Unlike many treatments of this issue, which consider endangered species management a science‐based problem, we suggest that a clear decision‐making process is equally necessary. In the face of new threats due to climate change, managers’ choices about endangered species require closely linked analyses and deliberations that identify key objectives and develop measurable attributes, generate and compare management alternatives, estimate expected consequences and key sources of uncertainty, and clarify trade‐offs across different dimensions of value. Several recent cases of endangered species conservation decisions illustrate our proposed decision‐focused approach, including Gulf of Maine Atlantic salmon (Salmo salar) recovery framework development, Cultus Lake sockeye salmon (Oncorhynchus nerka) management, and Upper Columbia River white sturgeon (Acipenser transmontanus) recovery planning.
In vitro studies of prolonged synaptic depression in the neonatal rat spinal cord.

1. Synaptic transmission between dorsal root afferents and alpha‐motoneurones was studied in the in vitro hemisected spinal cord preparation isolated from neonatal rats. 2. Repetitive stimulation of the dorsal roots depressed the monosynaptic reflex recorded from the homologous ventral roots. The depression developed within the first five to six pulses in a stimulus train and stabilized at a plateau‐like level for many seconds of stimulation. 3. The magnitude of the reflex depression depended on the stimulation interval and was capable of reducing the reflex to 17% of its undepressed control during 5 Hz stimulus trains. Complete recovery from depression was obtained at stimulation intervals greater than or equal to 30 s. 4. Monosynaptic excitatory postsynaptic potentials (EPSPs) were recorded intracellularly after reduction of the activity in polysynaptic pathways by addition of mephenesin to the bathing media. These EPSPs exhibited a prolonged, frequency‐dependent synaptic depression. The depression reduced the amplitude of the EPSP to 25% of the undepressed control during 5 Hz stimulus trains, and was alleviated completely at stimulus interval greater than or equal to 60 s. 5. The prolonged EPSP depression was not altered by blockade of glycinergic and type‐A gamma‐aminobutyric acid (GABAA‐ergic) receptors underlying postsynaptic inhibition in the spinal cord. Injection of current steps to motoneurones before and during the prolonged depression revealed similar values of the membrane time constant and input resistance. These excluded changes in the passive properties of the motoneurone membrane as an explanation for the observed synaptic depression. 6. Extracellular recordings of terminal potentials and their accompanying synaptic fields from motor nuclei in the ventrolateral cord revealed that the frequency‐dependent depression in the synaptic fields was not preceded by any detectable changes in the amplitude or the shape of the terminal potential, suggesting that the depression cannot be attributed to impairment of action potential invasion to the afferent terminals. 7. Reduction of the basic level of transmitter release in the spinal cord by increasing the Mg2+/Ca2+ ratio of the bathing solution or by application of 2 microM of L(‐)baclofen markedly diminished the synaptic potential depression at all the stimulation intervals tested in this study. Recovery from depression was evident for stimulation intervals greater than or equal to 5 s. Under these conditions, short tetanic trains (5 pulses at 25 Hz) revealed a substantial facilitation and potentiation of the EPSPs. 8. We suggest that prolonged depression of synaptic potentials in the neonatal rat reflects decreased transmitter output from the activated afferent terminals. (ABSTRACT TRUNCATED AT 400 WORDS)
Displacement of SATB1-Bound Histone Deacetylase 1 Corepressor by the Human Immunodeficiency Virus Type 1 Transactivator Induces Expression of Interleukin-2 and Its Receptor in T Cells

ABSTRACT One hallmark of human immunodeficiency virus type 1 (HIV-1) infection is the dysregulation of cytokine gene expression in T cells. Transfection of T cells with human T-cell leukemia type 1 or 2 transactivator results in the induction of the T-cell-restricted cytokine interleukin-2 (IL-2) and its receptor (IL-2Rα). However, no T-cell-specific factor(s) has been directly linked with the regulation of IL-2 and IL-2Rα transcription by influencing the promoter activity. Thymocytes from SATB1 (special AT-rich sequence binding protein 1) knockout mice have been shown to ectopically express IL-2Rα, suggesting involvement of SATB1 in its negative regulation. Here we show that SATB1, a T-cell-specific global gene regulator, binds to the promoters of human IL-2 and IL-2Rα and recruits histone deacetylase 1 (HDAC1) in vivo. SATB1 also interacts with Tat in HIV-1-infected T cells. The functional interaction between HIV-1 Tat and SATB1 requires its PDZ-like domain, and the binding of the HDAC1 corepressor occurs through the same. Furthermore, Tat competitively displaces HDAC1 that is bound to SATB1, leading to increased acetylation of the promoters in vivo. Transduction with SATB1 interaction-deficient soluble Tat (Tat 40-72) and reporter assays using a transactivation-negative mutant (C22G) of Tat unequivocally demonstrated that the displacement of HDAC1 itself is sufficient for derepression of these promoters in vivo. These results suggest a novel mechanism by which HIV-1 Tat might overcome SATB1-mediated repression in T cells.
Community policing and young people: a critical insight into young people's perceptions in Leicester

The repercussions associated with young people's exclusion from policing can be detrimental. The police will lack a basic understanding of young people s problems, needs and expectations. In these situations, young people will be less inclined to report crimes and their own victimisation to the police, provide intelligence, and participate in the criminal justice system. This study is intended to provide a critical appraisal of young people s perceptions of Police and Community Support Officers (PCSOs) and community policing in Leicester, in an effort to delineate the implications of their exclusion from local policing and crime related issues. Community policing is a well-known policing philosophy, particularly for repairing police public relations through engagement and problem solving. The findings demonstrate that despite the fundamental benefits associated with community policing, conventional methods of engagement and problem solving have failed to reach out to young people who are, nevertheless, particularly enthusiastic about collaborating with the police. However, whilst the vast majority of young people are positive about getting involved in policing, there are important variations within young people in their perceptions and attitudes towards the police. Young ethnic minorities in general, blacks in particular, were passive and reluctant to collaborate with the police due to their experiences of stop and search and other repercussion associated with the law enforcement style of policing. A lot of these problems can be subsided by diverting police resources to community policing, but there are going to be strong financial, organisational and cultural challenges.
Mutual interactions of boar seminal plasma proteins studied by immunological and chromatographic methods

Mammalian fertilization includes highly regulated biochemical interactions: binding of seminal plasma proteins to the sperm surface during ejaculation, interaction of sperm surface proteins with oviductal epithelial cells, sperm capacitation, gamete recognition, primary binding of the sperm to the ovum, etc. Spermadhesins, sperm binding proteins of seminal plasma, play roles in all these events. The plasma membrane of spermatozoa undergoes extensive remodeling when sperm mixes with seminal plasma proteins at ejaculation. Some proteins of seminal plasma become sperm‐coating agents. Two types of interactions could be involved in this process: (i) the interaction of proteins with the sperm membrane, (ii) mutual interactions between protein components. The second type of interactions is the subject of the present communication. Proteins of boar seminal plasma have been shown to be present mostly as aggregates of different composition and binding properties. Mutual interactions of proteins of boar seminal plasma likely to form aggregates were investigated by gel chromatography and affinity chromatography on immobilized spermadhesins. The protein composition of boar seminal plasma fractions adsorbed to immobilized spermadhesins was found to correspond to that of aggregated forms of seminal plasma proteins. Mutual interactions of isolated proteins were tested by gel chromatography and by specific antibodies against spermadhesins. The results obtained confirmed the existence of complex formation between spermadhesins of the AQN and AWN families, as well as between proteins involved in the formation of heterodimer PSP I/PSP II. Aggregated forms of spermadhesins are likely to be physiologically important in fertilization.
Clinical Usefulness of Culturing H. Pylori from Gastric Juice in Patients with Severe Neurological Impairment

Objectives: To clarify the diagnostic usefulness of culturing Helicobacter pylori from gastric juice for the diagnosis of H. pylori infection in patients with neurologic impairment. Methods: Seventy-five patients (44 males, 31 females) with severe neurologic impairment admitted to Tokyo Children’s Rehabilitation Hospital were included in this study. Samples of gastric juice obtained from these patients were put into Helicoporter™, a transport medium for H. pylori. Samples were then centrifuged and sediment was inoculated onto a culture medium. Polymerase chain reaction assays were performed on 41 gastric juice samples for comparison with results of culture. Tests for occult blood in gastric juice and serum anti-H. pylori immunoglobulin G were tested for all patients. Results: H. pylori was isolated from 33 of 75 gastric juice samples by culture (positive rate, 44%). There was agreement between results of culture and polymerase chain reaction assays in 38 samples (93%). Twenty-two samples were positive and 16 were negative by both methods. In H. pylori immunoglobulin G-positive patients, occult blood was more frequently found in the culture-positive group (92%) than in the culture-negative group (59%) (P <0.025). The rate of detection of occult blood in immunoglobulin G-negative patients was similar in the culture-positive group (44%) and culture-negative group (50%). Conclusions: The combination of a culture method using gastric juice and a serum H. pylori immunoglobulin G assay was not invasive and clinically useful for evaluating H. pylori infections among handicapped patients.
Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study

The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD‐MCI). Perfusion single photon emission computed tomography was performed in 15 PD‐MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS‐III scores were considered as confounding variables. PD‐MCI group (P < 0.05, false discovery rate–corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI‐PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly right cuneus and angular gyrus, and left precuneus and middle occipital gyrus. With a less conservative threshold (uncorrected P < 0.01), MCI‐PD showed hypoperfusion in a left parietal region, mainly including precuneus and inferior parietal lobule, and in a right temporal‐parietal‐occipital region, including middle occipital and superior temporal gyri, and cuneus‐precuneus, as compared to PD. aMCI versus PD‐MCI showed hypoperfusion in bilateral medial temporal lobe, anterior cingulate, and left orbitofrontal cortex. PD‐MCI patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD. The relevance of this pattern in predicting dementia should be evaluated in longitudinal studies. © 2008 Movement Disorder Society
Atlas‐based multichannel monitoring of functional MRI signals in real‐time: Automated approach

We report an automated method to simultaneously monitor blood‐oxygenation‐level‐dependent (BOLD) MR signals from multiple cortical areas in real‐time. Individual brain anatomy was normalized and registered to a pre‐segmented atlas in standardized anatomical space. Subsequently, using real‐time fMRI (rtfMRI) data acquisition, localized BOLD signals were measured and displayed from user‐selected areas labeled with anatomical and Brodmann's Area (BA) nomenclature. The method was tested on healthy volunteers during the performance of hand motor and internal speech generation tasks employing a trial‐based design. Our data normalization and registration algorithm, along with image reconstruction, movement correction and a data display routine were executed with enough processing and communication bandwidth necessary for real‐time operation. Task‐specific BOLD signals were observed from the hand motor and language areas. One of the study participants was allowed to freely engage in hand clenching tasks, and associated brain activities were detected from the motor‐related neural substrates without prior knowledge of the task onset time. The proposed method may be applied to various applications such as neurofeedback, brain‐computer‐interface, and functional mapping for surgical planning where real‐time monitoring of region‐specific brain activity is needed. Hum Brain Mapp 2008. © 2007 Wiley‐Liss, Inc.
Micropattern gas detector technologies and applications the work of the RD51 collaboration

The RD51 collaboration was founded in April 2008 to coordinate and facilitate efforts for development of micropattern gaseous detectors (mpgds). The 75 institutes from 25 countries bundle their effort, experience and resources to develop these emerging micropattern technologies. Mpgds are already employed in several nuclear and high-energy physics experiments, medical imaging instruments and photodetection applications; many more applications are foreseen. They outperform traditional wire chambers in terms of rate capability, time and position resolution, granularity, stability and radiation hardness. RD51 supports efforts to make mpgds also suitable for large areas, increase cost-efficiency, develop portable detectors and improve ease-of-use. The collaboration is organized in working groups which develop detectors with new geometries, study and simulate their properties, and design optimized electronics. Among the common supported projects are creation of test infrastructure such as beam test and irradiation facilities, and the production workshop.
Efficient “On‐the‐Fly” calculation of Raman Spectra from Ab‐Initio molecular dynamics: Application to hydrophobic/hydrophilic solutes in bulk water

We present a novel computational method to accurately calculate Raman spectra from first principles. Together with an extension of the second‐generation Car‐Parrinello method of Kühne et al. (Phys. Rev. Lett. 2007, 98, 066401) to propagate maximally localized Wannier functions together with the nuclei, a speed‐up of one order of magnitude can be observed. This scheme thus allows to routinely calculate finite‐temperature Raman spectra “on‐the‐fly” by means of ab‐initio molecular dynamics simulations. To demonstrate the predictive power of this approach we investigate the effect of hydrophobic and hydrophilic solutes in water solution on the infrared and Raman spectra. © 2015 Wiley Periodicals, Inc.
Proportional Response Based Bandwidth Allocation for Layered P2P Live Streaming

This paper presents the analysis and design of proportional response incentive mechanism for layered P2P live streaming systems. It is shown that, under the proportional response mechanism, high contribution peers are guaranteed to get a better streaming quality. Furthermore, the sensitivity parameter of the mechanism can be used to achieve the tradeoff between fairness and efficiency. It is also shown that, to avoid the content bottleneck problem, the sensitivity parameter must be within some specific ranges to ensure a high throughout of the P2P network. The theoretical results are then applied to the design of a layered P2P streaming system, where peers use a guided layer allocation algorithm to subscribe to the most suitable video layers and an efficient packet scheduling algorithm to exchange data with each other. Packet-level simulation experiments show that the optimized system outperforms other previous systems in both performance and fairness.
The multi-session audio research project (MARP) corpus: goals, design and initial findings

Abstract : This project describes the composition and goals of the Multi-session Audio Research Project (MARP) corpus and some initial experimental findings. The MARP corpus is a three year longitudinal collection of 21 sessions and more than 60 participants. This study was undertaken to test the impact of various factors on speaker recognition, such as inter-session variability, intonation, aging, whispering and text dependency. Initial results demonstrate the impact of sentence intonation, whispering, text dependency and cross session tests. These results highlight the sensitivity of speaker recognition to vocal, environmental and phonetic conditions that are commonly encountered but rarely explored or tested.
Human Parainfluenza Virus Type 4 Is Incapable of Evading the Interferon-Induced Antiviral Effect

ABSTRACT The V proteins of some paramyxoviruses have developed the ability to efficiently inactivate STAT protein function as a countermeasure for evading interferon (IFN) responses. Human parainfluenza virus type 4 (hPIV4) is one of the rubulaviruses, which are members of the family Paramyxoviridae, and has a V protein with a highly conserved cysteine-rich domain that is the hallmark of paramyxovirus V proteins. In order to study the function of the hPIV4 V protein, we established HeLa cells expressing the hPIV4A V protein (HeLa/FlagPIV4V). The hPIV4 V protein had no ability to reduce the level of STAT1 or STAT2, although it associated with STAT1, STAT2, DDB1, and Cul4A. It interfered with neither STAT1 and STAT2 tyrosine phosphorylation nor IFN-induced STAT nuclear accumulation. In addition, HeLa/FlagPIV4V cells are fully sensitive to both beta interferon (IFN-β) and IFN-γ, indicating that the hPIV4 V protein has no ability to block IFN-induced signaling. We further established HeLa cells expressing various chimeric proteins between the hPIV2 and hPIV4A V proteins. The lack of IFN-antagonistic activity of the hPIV4 V protein is caused by both the P/V common and V-specific domains. At least two regions (amino acids [aa] 32 to 45 and aa 143 to 164) of hPIV4 V in the P/V common domain and one region (aa 200 to 212) of the C terminus are involved in the inability to evade the IFN-induced signaling. Moreover, we established HeLa cells persistently infected with hPIV4 to make sure of the inability to escape IFN and confirmed that hPIV4 is the only paramyxovirus analyzed to date that can't evade the IFN-induced antiviral responses.