Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation and simulation of LPI radar signals' low probability of exploitation

With the development of investigation technology, stealthy performance of modern LPI radar is not only related to the signal waveform, but also related to the signal processing methods the intercept receiver used. Using the most common signal processing methods extract the signal feature, and distinguish them by Neural Networks algorithm, take the recognition rate results as the metrication of LPE, to quantify and evaluate the effect that the secure waveform design have on minimizing the risk of divulging radar. And combine it with LPI coefficient to analyze signal waveform. The simulation result indicates that Poly-Phase Shift Keying signal has the best stealthy performance, Linear Frequency Modulation signal has low probability of interception, but high probability of exploitation, Frequency Shift Keying signal has the temperate stealthy feature and the result can be referred, when it comes to the LPI signal waveform design.
Parameter Estimation of Unstable Aircraft using Extreme Learning Machine

The parameter estimation of unstable aircraft using extreme learning machine method is presented. In the past, conventional methods such as output error method, filter error method, equation error method and non-conventional method such as artificial neural-network based methods have been used for aircraft’s aerodynamic parameter estimation. Nowadays, a trend of finding an accurate nonlinear function approximation is required to represent the aircraft’s equations-of-motion. Such type of nonlinear function approximation is usually achieved using artificial neural-network which is trained with the aircraft input-output flight data using a training algorithm. The accuracy of estimated parameters, which is achieved using the trained network, is highly dependent on the generalisation capability of the network which can be improved using extreme learning machine based network in contrast to artificial neural-network. To estimate the unstable aircraft parameters from the simulated flight data, Gauss-Newton based optimisation method has been used with a predefined aerodynamic model using the trained network. Further, the confidence of the estimated parameters has been shown in comparison to that of the standard parameter estimation methods in terms of the Cramer-Rao bounds.
Comparing Cognitive, Metacognitive, and Acceptance and Commitment Therapy Models of Depression: a Longitudinal Study Survey

Abstract This study analyzed the interrelationships between key constructs of cognitive therapy (CT; depressogenic schemas), metacognitive therapy (MCT; dysfunctional metacognitive beliefs), and acceptance and commitment therapy (ACT; psychological inflexibility) in the prediction of depressive symptoms. With a lapse of nine months, 106 nonclinical participants responded twice to an anonymous online survey containing the following questionnaires: the Depression subscale of the Depression Anxiety and Stress Scales (DASS), the Dysfunctional Attitude Scale Revised (DAS-R), the Positive beliefs, Negative beliefs and Need to control subscales of the Metacognitions Questionnaire-30 (MCQ-30), and the Acceptance and Action Questionnaire – II (AAQ-II). Results showed that when controlling for baseline levels of depressive symptoms and demographic variables, psychological inflexibility longitudinally mediated the effect of depressogenic schemas (path ab = .023, SE = .010; 95% BC CI [.008, .048]) and dysfunctional metacognitive beliefs on depressive symptoms (positive metacognitive beliefs: path ab = .052, SE = .031; 95% BC CI [.005, .134]; negative metacognitive beliefs: path ab = .087, SE = .049; 95% BC CI [.016, .214]; need to control: path ab = .087, SE = .051; 95% BC CI [.013, .220]). Results are discussed emphasizing the role of psychological inflexibility in the CT and MCT models of depression.
Mutational analysis of human T-cell leukemia virus type 2 Tax

A mutational analysis of human T-cell leukemia virus type 2 (HTLV-2) Tax (Tax-2) was performed to identify regions within Tax-2 important for activation of promoters through the CREB/ATF or NF-kappaB/Rel signaling pathway. Tax-2 mutations within the putative zinc-binding region as well as mutations at the carboxy terminus disrupted CREB/ATF transactivation. A single mutation within the central proline-rich region of Tax-2 disrupted the transactivation of the NF-kappaB/Rel pathway. Surprisingly, this mutation, which is thought to be in a separate activation domain, was suppressed by mutations within or around the putative zinc-binding region, suggesting an interaction between these two regions. These analyses indicate that the functional regions or domains important for transactivation through the CREB/ATF or NF-kappaB/Rel signaling pathway are similar, but not identical, in Tax-1 and Tax-2. Identification of these distinct Tax-2 mutants should facilitate comparative biological studies of HTLV-1 and HTLV-2 and ultimately lead to the determination of the functional importance of Tax trans-acting capacities in T-lymphocyte transformation by HTLV.
Effects of reduced joint mobility and training on Na, K‐ATPase and Ca‐ATPase in skeletal muscle

In guinea pigs, the ankle joint was partly immobilized in a position reducing dorsiflection to 105° (as compared to the normal value of 30°). When compared with the contralateral unrestrained leg, this led to a significant atrophy and a decrease in contractile force (−23%) of the gastrocnemius and plantaris muscle reaching minimum (−19% and −23%) after 3 weeks, but no evidence of degenerative changes. Total contents of Ca and Ca‐ATPase were increased by 27% and 22%, respectively. After 4 to 5 weeks of reduced mobility, the concentration of [3H]ouabain binding sites in gastrocnemius muscle returned to control level. The lowest concentration of [3H]ouabain binding sites reached during reduced mobility was 258 ± 13 pmol/g wet wt. , and the maximum value attained following 3 weeks of reduced mobility and 3 weeks of training by running was 498 ± 25 pmol/g wet wt. , i.e, 93% higher. In soleus, training produced an increase of 25%. Clinically, it is important to realize that movable braces cannot prevent the development of muscular atrophy. The observed spontaneous recovery of the Na, K‐pump concentration may partly explain why patients using movable casts show a better capacity for physical performance than those treated with complete immobilization. In conclusion, the total concentration of Na, K‐pumps in guinea pig skeletal muscle undergoes downregulation and upregulation as a function of contractile activity as well as muscle length under conditions mimicking the constraints on mobility frequently used in the clinical treatment of lesions. © 1992 John Wiley & Sons, Inc.
Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome*

Background: The inflammasome is a multimolecular complex that regulates the processing of the pro-inflammatory cytokine interleukin-1β. Results: Inhibitors of deubiquitinase (DUB) enzymes inhibited the release of interleukin-1β. Conclusion: DUBs regulate assembly of the inflammasome. Significance: DUBs may represent new anti-inflammatory drug targets for the treatment of inflammatory disease. IL-1β is a potent pro-inflammatory cytokine produced in response to infection or injury. It is synthesized as an inactive precursor that is activated by the protease caspase-1 within a cytosolic molecular complex called the inflammasome. Assembly of this complex is triggered by a range of structurally diverse damage or pathogen associated stimuli, and the signaling pathways through which these act are poorly understood. Ubiquitination is a post-translational modification essential for maintaining cellular homeostasis. It can be reversed by deubiquitinase enzymes (DUBs) that remove ubiquitin moieties from the protein thus modifying its fate. DUBs present specificity toward different ubiquitin chain topologies and are crucial for recycling ubiquitin molecules before protein degradation as well as regulating key cellular processes such as protein trafficking, gene transcription, and signaling. We report here that small molecule inhibitors of DUB activity inhibit inflammasome activation. Inhibition of DUBs blocked the processing and release of IL-1β in both mouse and human macrophages. DUB activity was necessary for inflammasome association as DUB inhibition also impaired ASC oligomerization and caspase-1 activation without directly blocking caspase-1 activity. These data reveal the requirement for DUB activity in a key reaction of the innate immune response and highlight the therapeutic potential of DUB inhibitors for chronic auto-inflammatory diseases.
Marriage and Same-sex Couples after Obergefell

Author(s): Gates, Gary; Brown, Taylor NT | Abstract: This research brief analyzes the impact of the US Supreme Court’s decisions in Windsor v. United States (June 2013) and Obergefell v. Hodges (June 2015) on marriage by same-sex couples. In 2013, the year that the Windsor ruling was issued, an estimated 230,000 same-sex couples were married, 21% of all same-sex couples. By June 2015, when Obergefell was decided, 390,000 same-sex couples were married, 38% of all same-sex couples. As of October 2015, 486,000 same-sex couples were married, or 45% of all same-sex couples. The legal benefits and obligations of marriage now support these married couples, more than a quarter of whom are raising children, and the visibility of these families will likely continue to accelerate public support for marriage equality in the United States.
A common mode noise filter for high speed and wide band differential mode signal transmission

This study shows the noise reduction characteristics of a noise filter composed of a common mode choke and a differential mode choke. A common mode choke is usually used for the common mode noise reduction on a differential mode signal transmission line. The common mode choke attenuates the common mode noise and passes the differential mode signal on the signal transmission line. The common mode choke works as a high impedance element for the common mode noise and as a low impedance element for the differential mode signal. However, it is difficult to realize a large reduction effect of noise in wide frequency range by using only a common mode choke. A special feature of the common mode noise filter proposed in this paper is to have a differential mode choke added to a common mode choke. The differential mode choke works as a low impedance element for common mode noise and as a high impedance element for differential mode signal. The noise filter studied in this paper reduces common mode noise 20dB or more and demonstrates the good transmission characteristics of a differential mode signal in the wide frequency range from 1MHz to 1GHz. In addition, this filter generates very small differential mode component converted from a common mode noise.
Factors that affect Students Decision to Choose Private Universities in Medan City Indonesia

This study is aimed to determine the factors that influence student decisions in choosing private universities in Medan. The variables that observed were: education fee, promotion, brand image, motivation and facility as exogenous variable and student decision as endogen variable. The sample was determined by quota sampling on 150 students as respondents. The research data was obtained by surveys, questionnaires and interviews that then tested by testing the validity of the construct (indicator) and reliability test of the value of construct reliability. Data analysis used factor tests with regression weights and Confirmatory Factory Analysis (CFA). The model feasibility test used sample size, normality test and goodness of fit test. The results of this study indicate that the fee of education, promotion, brand image, motivation and facilities have a positive and significant effect on the decision of students in choosing private universities in Medan. All constructs forming each variable can explain its existence to latent variables. Moreover, the results of respondents' answers were also found that accreditation is a determining factor for prospective students in choosing private universities in Medan.
Effect of proinflammatory cytokines on interleukin-8 mRNA expression and protein production by isolated human alveolar epithelial cells type II in primary culture.

Alveolar epithelial cells type II (AEC-II) are ideally situated to regulate the recruitment and activation of different types of cells through the production of chemokines in response to inflammatory stimulation from the alveolar space. We hypothesized that these cells are important producers of interleukin-8 (IL-8) in the lung. This lead us to investigate the capacity of isolated human AEC-II cells to release IL-8 and whether this IL-8 release is regulated by proinflammatory cytokines, i.e. IL-1 beta, TNF-alpha and IFN-gamma. We isolated AEC-II from tumor-free sections of human lungs obtained by pneumectomy and purified the cells by magnetic activated cell sorting. For control experiments the AEC-II-like cell line A549 was used. IL-8 concentration was measured by ELISA in supernatants of unstimulated and LPS-, IL-1 beta-, TNF-alpha- and IFN-gamma- stimulated cells. IL-8 mRNA expression was evaluated by RT-PCR. Spontaneous IL-8 mRNA expression and protein secretion by AEC-II were significantly higher in comparison with A549 cells. TNF-alpha increased both IL-8 mRNA expression and protein production, whereas IL-1 beta slightly increased IL-8 release but did not change mRNA expression in AEC-II. LPS and IFN-gamma did not influence IL-8 expression in AEC-II and A549 cells. These results show considerable differences between A549 cell and AEC-II. The latter are capable of producing IL-8 under the control of proinflammatory cytokines. Our findings demonstrate that the modulation of IL-8 release in AEC-II may have an important impact on the immunoreactivity of these cells during pulmonary inflammation in vivo.
Cellular Form of Prion Protein Inhibits Reelin-Mediated Shedding of Caspr from the Neuronal Cell Surface to Potentiate Caspr-Mediated Inhibition of Neurite Outgrowth

Extension of axonal and dendritic processes in the CNS is tightly regulated by outgrowth-promoting and -inhibitory cues to assure precision of synaptic connections. We identify a novel role for contactin-associated protein (Caspr) as an inhibitory cue that reduces neurite outgrowth from CNS neurons. We show that proteolysis of Caspr at the cell surface is regulated by the cellular form of prion protein (PrP), which directly binds to Caspr. PrP inhibits Reelin-mediated shedding of Caspr from the cell surface, thereby increasing surface levels of Caspr and potentiating the inhibitory effect of Caspr on neurite outgrowth. PrP deficiency results in reduced levels of Caspr at the cell surface, enhanced neurite outgrowth in vitro, and more efficient regeneration of axons in vivo following spinal cord injury. Thus, we reveal a previously unrecognized role for Caspr and PrP in inhibitory modulation of neurite outgrowth in CNS neurons, which is counterbalanced by the proteolytic activity of Reelin.
AbaR4 replaces AbaR3 in a carbapenem-resistant Acinetobacter baumannii isolate belonging to global clone 1 from an Australian hospital.

OBJECTIVES To explore the diversity of genomic resistance islands in multiply antibiotic-resistant Acinetobacter baumannii isolates in global clone 1 (GC1) from Australian hospitals. METHODS PCR was used to characterize isolates, detect antibiotic resistance genes and insertion sequences and screen for genomic resistance islands. Structures of genomic islands were determined by PCR mapping and sequencing. Multilocus sequence typing was performed using the Oxford scheme. RESULTS Eleven isolates that belong to GC1 were found among 90 A. baumannii isolated between 2001 and 2010 at Australian hospitals, and 5 were carbapenem resistant. Ten isolates had the features characteristic of AbaR3 and related islands, but one carbapenem-resistant isolate did not. Instead, D36 carried the bla(OXA-23) gene in transposon Tn2006, with Tn2006 in AbaR4, and AbaR4 in the chromosomal comM gene, replacing the AbaR3-type island usually associated with multiply antibiotic-resistant GC1 isolates. D36 was resistant to gentamicin, kanamycin and tobramycin due to the aadB gene cassette in the context found in plasmid pRAY and to sulfamethoxazole due to the sul2 gene. D36 was of a rare sequence type (ST), ST247. Bioinformatic analysis identified five potential transposition genes in the AbaR backbone transposons. CONCLUSIONS Substantial diversity was observed among the GC1 isolates. This is the first report of AbaR4 replacing the AbaR3-type island seen in most GC1 isolates, and D36 represents a distinct new GC1 lineage. The AbaRs are members of a large, previously undocumented family of transposons that target comM.
Value of Medical Innovation in the United States: 1960-2000

Background: The increased use of medical therapies has led to increased medical costs. To provide insight into the value of this increased spending, we compared gains in life expectancy with the increased costs of care from 1960 through 2000. Methods: We estimated life expectancy in 1960, 1970, 1980, 1990, and 2000 for four age groups. To control for the influence of nonmedical factors on survival, we assumed in our base-case analysis that 50 percent of the gains were due to medical care. We compared the adjusted increases in life expectancy with the lifetime cost of medical care in the same years. Results: From 1960 through 2000, the life expectancy for newborns increased by 6.97 years, lifetime medical spending adjusted for inflation increased by approximately $69,000, and the cost per year of life gained was $19,900. The cost increased from $7,400 per year of life gained in the 1970s to $36,300 in the 1990s. The average cost per year of life gained in 1960â€“2000 was approximately $31,600 at 15 years of age, $53,700 at 45 years of age, and $84,700 at 65 years of age. At 65 years of age, costs rose more rapidly than did life expectancy: the cost per year of life gained was $121,000 between 1980 and 1990 and $145,000 between 1990 and 2000. Conclusions: On average, the increases in medical spending since 1960 have provided reasonable value. However, the spending increases in medical care for the elderly since 1980 are associated with a high cost per year of life gained. The national focus on the rise in medical spending should be balanced by attention to the health benefits of this increased spending.
Effects of prosodic emotional intensity on activation of associative auditory cortex

Functional magnetic resonance imaging was used to investigate hemodynamic responses to adjectives pronounced in happy and angry intonations of varying emotional intensity. In separate sessions, participants judged the emotional valence of either intonation or semantics. To disentangle effects of emotional prosodic intensity from confounding acoustic parameters, mean and variability of volume and fundamental frequency of each stimulus were included as nuisance variables in the statistical models. A linear dependency between hemodynamic responses and emotional intensity of happy and angry intonations was found in the bilateral superior temporal sulcus during both tasks, indicating that increases of hemodynamic responses in this region are elicited by both positive and negative prosody independent of low-level acoustic properties and task instructions.
Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants

Significance We carried out functional analysis of the oat enzyme AsCYP51H10, which is a divergent member of the CYP51 cytochrome P450 family and showed that this enzyme is able to catalyze both hydroxylation and epoxidation of the simple triterpene β-amyrin to give 12,13β-epoxy-3β,16β-dihydroxy-oleanane (12,13β-epoxy-16β-hydroxy-β-amyrin). In contrast, the canonical CYP51 enzymes are highly conserved and catalyze only sterol demethylation. We further show that the C12,13 epoxy group is critical for antifungal activity, a discovery that has important implications for triterpene metabolic engineering for food, health, and industrial biotechnology applications. Members of the cytochromes P450 superfamily (P450s) catalyze a huge variety of oxidation reactions in microbes and higher organisms. Most P450 families are highly divergent, but in contrast the cytochrome P450 14α-sterol demethylase (CYP51) family is one of the most ancient and conserved, catalyzing sterol 14α-demethylase reactions required for essential sterol synthesis across the fungal, animal, and plant kingdoms. Oats (Avena spp.) produce antimicrobial compounds, avenacins, that provide protection against disease. Avenacins are synthesized from the simple triterpene, β-amyrin. Previously we identified a gene encoding a member of the CYP51 family of cytochromes P450, AsCyp51H10 (also known as Saponin-deficient 2, Sad2), that is required for avenacin synthesis in a forward screen for avenacin-deficient oat mutants. sad2 mutants accumulate β-amyrin, suggesting that they are blocked early in the pathway. Here, using a transient plant expression system, we show that AsCYP51H10 is a multifunctional P450 capable of modifying both the C and D rings of the pentacyclic triterpene scaffold to give 12,13β-epoxy-3β,16β-dihydroxy-oleanane (12,13β-epoxy-16β-hydroxy-β-amyrin). Molecular modeling and docking experiments indicate that C16 hydroxylation is likely to precede C12,13 epoxidation. Our computational modeling, in combination with analysis of a suite of sad2 mutants, provides insights into the unusual catalytic behavior of AsCYP51H10 and its active site mutants. Fungal bioassays show that the C12,13 epoxy group is an important determinant of antifungal activity. Accordingly, the oat AsCYP51H10 enzyme has been recruited from primary metabolism and has acquired a different function compared to other characterized members of the plant CYP51 family—as a multifunctional stereo- and regio-specific hydroxylase in plant specialized metabolism.
Preventing Participation of Insincere Workers in Crowdsourcing by Using Pay-for-Performance Payments

We propose a method for finding an appropriate setting of a pay-per-performance payment system to prevent participation of insincere workers in crowdsourcing. Crowdsourcing enables fast and low-cost accomplishment of tasks; however, insincere workers prevent the task requester from obtaining high-quality results. Instead of a fixed payment system, the pay-per-performance payment system is promising for excluding insincere workers. However, it is difficult to learn what settings are better, and a naive payment setting may cause unsatisfactory outcomes. To overcome these drawbacks, we propose a method for calculating the expected payments for sincere and insincere workers, and then clarifying the conditions in the payment setting in which sincere workers are willing to choose a task, while insincere workers are not willing to choose the task. We evaluated the proposed method by conducting several experiments on tweet labeling tasks in Amazon Mechanical Turk. The results suggest that the pay-per-performance system is useful for preventing participation of insincere workers. key words: crowdsourcing, mechanism design