Miracle-dz/UniFAR-FTUs huggingface dataset:
Naringenin and 17β‐estradiol coadministration prevents hormone‐induced human cancer cell growth

Flavonoids have been described as health‐promoting, disease‐preventing dietary components. In vivo and in vitro experiments also support a protective effect of flavonoids to reduce the incidence of certain hormone‐responsive cancers. In particular, our previous results indicate that the flavanone naringenin (Nar), decoupling estrogen receptor α (ERα) action mechanisms, drives cancer cells to apoptosis. Because these studies were conducted in the absence of the endogenous hormone 17β‐estradiol (E2), the physiological relevance of these findings is not clear. We investigate whether the antiproliferative Nar effect persists in the presence of physiological E2 concentration (i.e. 10 nM), using both ERα‐transfected (HeLa cells) and ERα‐containing (HepG2 cells) cancer cell lines. Ligand saturation experiments indicate that Nar decreases the binding of E2 to ERα without impairing the estrogen response element (ERE)‐driven reporter plasmid activity. In contrast, Nar stimulation prevents E2‐induced extracellular regulated kinases (ERK1/2) and AKT activation and still induces the activation of p38, the proapoptotic member of mitogen‐activating protein kinase (MAPK) family. As a consequence, Nar stimulation impedes the E2‐induced transcription of cyclin D1 promoter and reverts the E2‐induced cell proliferation, driving cancer cell to apoptosis. Thus, these results suggest that coexposure to this low‐affinity, low‐potency ligand for ERα specifically antagonizes the E2‐induced ERα‐dependent rapid signals by reducing the effect of the endogenous hormone in promoting cellular proliferation. As a whole, these data indicate that Nar is an excellent candidate as a chemopreventive agent in E2‐dependent cancers. © 2009 IUBMB IUBMB Life, 62(1):51–60, 2010
DETECTION OF SINGLE CELLS SECRETING IFN‐GAMMA, IL‐6, AND IL‐10 IN IRREVERSIBLY REJECTED HUMAN KIDNEY ALLOGRAFTS, AND THEIR MODULATION BY IL‐2 AND IL‐4

The frequency of isolated low-density graft-infiltrating cells (GIC) secreting IFN-γ, IL-6, and IL-10 was studied in 8 cases of irreversible rejection of human renal allografts, using ELISA and SPOT-forming cells (ELISPOT) assays. The GIC were mostly CD8+ T cells, although CD4+ T cells, B cells, and macrophages could also be detected. On the average, in 106 cells, 189 secreted IFN-γ, 747 IL-10, and 17114 IL-6. Culture of GIC in the presence of IL-2 resulted in an increase in the frequency of IFN-γ-producing cells (IFN-γ-PC), in a dose-dependent manner, with an optimal 6.5-fold increase at 50 U/ml. In contrast, 25 U/ml IL-4 decreased the frequency of spontaneous and IL-2-induced IFN-γ-PC by 71.3% and 52.8%, respectively. Furthermore, IL-4 reduced the frequency of IL-6-PC (56.8%). By this new approach to graft rejection, it becomes easier to determine cytokine profiles within an allograft and to study their modulation by different agents. It could be a useful model of study for the development of new treatment.
Integrate Military with Distributed Cloud Computing and Secure Virtualization

Cloud computing is known as a novel information technology (IT) concept, which involves facilitated and rapid access to networks, servers, data saving media, applications and services via Internet with minimum hardware requirements. Use of information systems and technologies at the battlefield is not new. Information superiority is a force multiplier and is crucial to mission success. Distributed cloud computing in the Military systems are operational today. In the near future extensive use of military clouds at the battlefield is predicted. Integrating cloud computing logic to military applications will increase the flexibility, cost-effectiveness, efficiency and accessibility capabilities. In this paper, distributed cloud computing concepts are defined. Cloud computing supported battlefield applications are analyzed. The effects of cloud computing systems on the information domain in future warfare are discussed. Battlefield opportunities and novelties which might be introduced by distributed cloud computing systems are researched. The role of military clouds in future warfare is proposed in this paper. It was concluded that military clouds will be indispensible components of the future battlefield. Military clouds have the potential of increasing situational awareness at the battlefield and facilitating the settlement of information superiority.
mwetoolkit+sem: Integrating Word Embeddings in the mwetoolkit for Semantic MWE Processing

This paper presents mwetoolkit+sem: an extension of the mwetoolkit that estimates semantic compositionality scores for multiword expressions (MWEs) based on word embeddings. First, we describe our implementation of vector-space operations working on distributional vectors. The compositionality score is based on the cosine distance between the MWE vector and the composition of the vectors of its member words. Our generic system can handle several types of word embeddings and MWE lists, and may combine individual word representations using several composition techniques. We evaluate our implementation on a dataset of 1042 English noun compounds, comparing different configurations of the underlying word embeddings and word-composition models. We show that our vector-based scores model non-compositionality better than standard association measures such as log-likelihood.
Anterior Prefrontal Function and the Limits of Human Decision-Making

The frontopolar cortex (FPC), the most anterior part of the frontal lobes, forms the apex of the executive system underlying decision-making. Here, we review empirical evidence showing that the FPC function enables contingent interposition of two concurrent behavioral plans or mental tasks according to respective reward expectations, overcoming the serial constraint that bears upon the control of task execution in the prefrontal cortex. This function is mechanistically explained by interactions between FPC and neighboring prefrontal regions. However, its capacity appears highly limited, which suggests that the FPC is efficient for protecting the execution of long-term mental plans from immediate environmental demands and for generating new, possibly more rewarding, behavioral or cognitive sequences, rather than for complex decision-making and reasoning.
Christianity and the Social Crisis

Walter Rauschenbusch was the primary architect of the Social Gospel, a movement that responded to the changing social and industrial conditions in the United States during the late nineteenth and early twentieth centuries. In this book, he presents his path-breaking and prophetic interpretation of Jesus and the kingdom and his understanding of troubling conditions that call the church to faithful witness and to work toward meaningful political and economic reforms. The Library of Theological Ethics series focuses on what it means to think theologically and ethically. It presents a selection of important and otherwise unavailable texts in easily accessible form. Volumes in this series will enable sustained dialogue with predecessors though reflection on classic works in the field.
MR molecular imaging of tumors based on an optimal hTERT promoter tyrosinase expression system

The early diagnosis and treatment of tumors is of vital significance to increase patient survival. Therefore, we constructed a lentiviral vector expressing tyrosinase (TYR) driven by an optimized human telomerase reverse transcriptase (hTERT) promoter or a cytomegalovirus(CMV) promoter in the hopes of performing noninvasive and real-time tumor-specific imaging. First, hTERT-TYR and CMV-TYR were constructed to infect cancer cell lines (telomerase-negative cell line: U2OS; telomerase-positive cell lines: SGC-7901, SW480 and HepG2). Subsequently, stable tyrosinase-expressing cell lines were sorted by flow cytometry out of these infected cancer cell lines. Then, the mRNA and protein levels of tyrosinase were analyzed. Thetyrosinase activity, melanin production and ferric ion adsorption were measured followed by an MR scan. Consequently the results showed that tyrosinase was only expressed in telomerase-positive tumor cells infected by hTERT-TYR, whereas tyrosinase was expressed in both telomerase-negative and telomerase-positive tumor cells infected by CMV-TYR. Finally, we performed in vivo tumor MR using a clinical 3T MR scanner and found increased signals at T1W1 from telomerase-positive cells infected by hTERT-TYR, which revealed that MR scanning could distinguish cells with hTERT -positive cells from hTERT-negative cells infected with the optimized lentivirus. The mechanism underlying this effect is that tyrosinase promotes melanin production and ferric ion adsorption only in hTERT-expressing cells. Taken together, these data show that this optimized hTERT promoter-driving tyrosinase expression system might be a useful diagnostic tool for the detection of tumors using MR imaging.
The Development of Working Memory in Children

Introduction The Working Memory Model How Is Working-Memory Measured? Working Memory and Typical Development: Part One Working Memory and Typical Development: Part Two Working Memory in Children with Intellectual Disabilities Working Memory, Dyslexia and Specific Language Impairment Working Memory in Children with Down's Syndrome and Williams Syndrome Working Memory in Children with Autistic Spectrum Disorders Concluding Comments
Preliminary Waveform Analysis for a New Concept of ATC Radar

The expected growth of air traffic in national and international airports requires the development of new, efficient air traffic management systems. A key objective is to develop new technologies for maximizing airspace and airport capacity and safety. The availability of accurate ground condition information, regardless of the information independently acquired by the aircraft or that provided by the controller via voice channel, is believed to be of considerable interest in increasing landing security. Currently, the radar surveillance function and the communication function toward approaching aircrafts are carried out separately: the airport's primary surveillance radar performs surveillance, while dedicated radio channels in the VHF band allow air-ground voice communications. In this context, this paper explores the possibility of combining the traditional tracking function performed by radar with the communication function, which automatically provides aircrafts, monitored near real time, with a series of data particularly useful for the final landing. The data at issue are typically those related to airport ground conditions, such as local air-meteorological conditions and airport runway management. This information is integrated into the waveform emitted by the radar, thus implementing a broadcast transmission channel, whose content can be automatically decoded by an aircraft equipped with an appropriate receiving system. The proposed study is a preliminary analysis of the topic, with the main purpose of assessing the feasibility of using radar and communication techniques in this particular application.
Divergence Function, Duality, and Convex Analysis

From a smooth, strictly convex function : Rn R, a parametric family of divergence function D() may be introduced: for x, y, int dom() and for R, with D(1 defined through taking the limit of . Each member is shown to induce an -independent Riemannian metric, as well as a pair of dual -connections, which are generally nonflat, except for = 1. In the latter case, D(1) reduces to the (nonparametric) Bregman divergence, which is representable using and its convex conjugate and becomes the canonical divergence for dually flat spaces (Amari, 1982, 1985; Amari & Nagaoka, 2000). This formulation based on convex analysis naturally extends the information-geometric interpretation of divergence functions (Eguchi, 1983) to allow the distinction between two different kinds of duality: referential duality ( -) and representational duality ( ). When applied to (not necessarily normalized) probability densities, the concept of conjugated representations of densities is introduced, so that -connections defined on probability densities embody both referential and representational duality and are hence themselves bidual. When restricted to a finite-dimensional affine submanifold, the natural parameters of a certain representation of densities and the expectation parameters under its conjugate representation form biorthogonal coordinates. The alpha representation (indexed by now, 1, 1) is shown to be the only measure-invariant representation. The resulting two-parameter family of divergence functionals D(, ), (, ) 1, 1 -1, 1 induces identical Fisher information but bidual alpha-connection pairs; it reduces in form to Amari's alpha-divergence family when =1 or when = 1, but to the family of Jensen difference (Rao, 1987) when = 1.
A novel strategy of radiofrequency hyperthermia (neothermia) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study

The safety of weekly regional hyperthermia performed with 8 MHz radiofrequency (RF) capacitive heating equipment has been established in rectal cancer. We aimed to standardize hyperthermia treatment for scientific evaluation and for assessing local tumor response to RF hyperthermia in rectal cancer. Forty‐nine patients diagnosed with rectal adenocarcinoma were included in the study. All patients received chemoradiation with intensity‐modulated radiation therapy 5 days/week (dose, 50 Gy/25 times) concomitant with 5 days/week for five times of capecitabine (1700 mg/m2 per day) and once a week for five times of 50 min irradiations by an 8 MHz RF capacitive heating device. Thirty‐three patients underwent surgery 8 weeks after treatment. Three patients did not undergo surgery because of progressive disease (PD) and 13 refused. Eight (16.3%) patients had a pathological complete response (ypCR) after surgery. Among patients without surgery, 3 (6.1%) had clinical complete response (CR) and 3 (6.1%) had local CR but distant PD (CRPD). Ninety percent of ypCR + CR patients were shown in 6.21 W min−1 m−2/treatment or higher group of average total accumulated irradiation output with 429°C min−1 m−2 or higher group of total accumulated thermal output. However, a patient with CRPD was in the higher total accumulated thermal output group. We propose a new quantitative parameter for the hyperthermia and demonstrated that patients can benefit from mild irradiation with mild temperature. Using these parameters, the exact output, optimal thermal treatment, and contraindications or indications of this modality could be determined in a multi‐institutional, future study.
Novel oncogene amplifications in tumors from a family with Li–Fraumeni syndrome

Li–Fraumeni syndrome (LFS) represents an inherited tumor syndrome that is typically caused by germline mutations of the tumor suppressor gene TP53. TP53 dysfunction secondarily disturbs the genetic integrity of the cell. Here, we report a family with LFS harboring a germline TP53 mutation (R248W) located in the functional domain of the protein that binds to the minor groove of the DNA. In this family, tumors of the central nervous system were diagnosed as primary malignancies in all carriers of the mutation. The index patient developed an anaplastic medulloblastoma with unusual genomic profile exhibiting six distinct high‐level genomic amplifications, two of them targeting the MYCN and GLI2 genes, respectively. In an extrarenal rhabdoid tumor from the same patient, we found a novel high‐level amplification of the MYC oncogene. The father of this patient was diagnosed with myxopapillary ependymoma (WHO °I), whereas a brother died from an early relapse of a choroid plexus carcinoma. The analysis of this LFS familiy thus revealed novel oncogene amplifications as different second hits that are likely to also play a role in the pathogenesis of their sporadic counterparts. © 2009 Wiley‐Liss, Inc.
Low-rank bases for factorized hidden layer adaptation of DNN acoustic models

Recently, the factorized hidden layer (FHL) adaptation method is proposed for speaker adaptation of deep neural network (DNN) acoustic models. An FHL contains a speaker-dependent (SD) transformation matrix using a linear combination of rank-1 matrices and an SD bias using a linear combination of vectors, in addition to the standard affine transformation. On the other hand, full-rank bases are used with a similar DNN adaptation method which is based on cluster adaptive training (CAT). Therefore, it is interesting to investigate the effect of the rank of the bases used for adaptation. The increase of the rank of the bases improves the speaker subspace representation, without increasing the number of learnable speaker parameters. In this work, we investigate the effect of using various ranks for the bases of the SD transformation of FHLs on Aurora 4, AMI IHM and AMI SDM tasks. Experimental results have shown that when one FHL layer is used, it is optimal to use low-ranked bases of rank-50, instead of full-rank bases. Furthermore, when multiple FHLs are used, rank-1 bases are sufficient.
Magnetism of Asymmetrically Terminated FeRh(001) Thin Films: A First-Principle Study

Rh-terminated FeRh(001) film is known to be stable in a ferromagnetic (FM) state different from a G-type antiferromagnetic (G-AFM) bulk ground state, while an Fe-terminated FeRh(001) film has the same ground state as the bulk. In this paper, we investigate the magnetic properties of asymmetrically terminated FeRh(001) films: one surface is Fe-terminated and the other is Rh-terminated. We found that the films thicker than eight monolayers (MLs) have more or less complicated magnetic configuration: the topmost three layers from the Rh-terminated surface are FM while the rest are G-AFM. In particular, the magnetic configuration of the 8-ML FeRh(001) film has lower energy than the whole-layer G-AFM and FM states by 10.2 and 0.2 meV/Fe, respectively. The magnetic configuration of the asymmetrically terminated films is explained by the magnetic energy gain due to the magnetization of the Rh atoms.
Combination of Acoustic Classifiers Based on Dempster-Shafer Theory of Evidence

In this paper we investigate combination of neural net based classifiers using Dempster-Shafer theory of evidence. Under some assumptions, combination rule resembles a product of errors rule observed in human speech perception. Different combination are tested in ASR experiments both in matched and mismatched conditions and compared with more conventional probability combination rules. Proposed techniques are particularly effective in mismatched conditions.
South African Educators' Voice on the Potential Role of Traditional Healers (THs) in Education Support Services

The aim of this qualitative research was to explore and describe perceptions of the potential role of traditional healers in education support services. Participants were 42 teachers (males = 13, females = 29) from a school district in the Eastern Cape province of South Africa. Interview and questionnaire data were collected and analysed, using a phenomenological method. Two main themes emerged from the analysis for the role of THs as education support providers: as 1) representatives of African culture and 2) contributors towards harmonising diversity in schools. The recommendations made were in line with the findings.
NATURAL COMPUTING/UNCONVENTIONAL COMPUTING AND ITS PHILOSOPHICAL SIGNIFICANCE

Classical computing has well-established formalisms for specifying, refining, composing, proving, and otherwise reasoning about computations. These formalisms have matured over the past 70 years or so. Unconventional Computing includes the use novel kinds of sub- strates – from black holes and quantum effects, through to chem- icals, biomolecules, even slime moulds – to perform computations that do not conform to the classical model. Although many of these substrates can be “tortured” to perform classical computation, this is not how they “naturally” compute. Our ability to exploit unconventional computing is partly ham- pered by a lack of corresponding programming formalisms: we need models for building, composing, and reasoning about programs that execute in these substrates. What might, say, a slime mould program- ming language look like? Here I outline some of the issues and properties of these uncon- ventional substrates that need to be addressed to find “natural” ap- proaches to programming them. Important concepts include embod- ied real values, processes and dynamical systems, generative systems and their meta-dynamics, and embodied self-reference.
Compact complex manifolds with the DOP and other properties

Abstract We point out that a certain complex compact manifold constructed by Lieberman has the dimensional order property, and has U-rank different from Morley rank. We also give a sufficient condition for a Kähler manifold to be totally degenerate (that is, to be an indiscernible set, in its canonical language) and point out that there are K3 surfaces which satisfy these conditions.
Efficient Cooperative Spectrum Sensing for Cognitive Wireless Relay Networks over Rayleigh Flat Fading Channels

This paper is concerned with cooperative spectrum sensing (CSS) mechanisms in cognitive wireless relay networks (CWRNs). Conventionally, the decision of available spectrum for cognitive radio (CR) users is carried out based on the global decision at a fusion center (FC). In this paper, we propose a new CSS scheme to improve the spectrum sensing performance by exploiting both local decisions at the CR users and global decisions at the FC. Particularly, by deriving the probabilities of missed detection and false alarm for a practical scenario where all sensing, reporting, and backward channels suffer from Rayleigh fading, we show that our proposed CSS scheme achieves an improved sensing performance over the conventional scheme. Furthermore, we propose a CSS scheme based on network coding (NC) for a specific CWRN where the transmission from a source node to a destination node is realized with the aid of two groups of CR users located in the transmission coverage of two primary users (PUs). The proposed NC-based CSS scheme helps reduce one phase of sensing for a higher system throughput compared to the conventional scheme which requires eight phases in total to monitor all available spectrums of both PUs.
A Short Overview of AspectL

AspectL adds a number of features to the Common Lisp Object System (CLOS) that have been developed in the recent years in the AOSD community. According to the Lisp spirit, some of them have been generalized in the process of translating them to Common Lisp. These generalizations are likely to be interesting for designers of other aspectoriented programming languages as well since the bulk of AspectL does not rely on Common Lisp specifics. However, this paper requires at least a general understanding of CLOS, as for example provided in the overviews by DeMichiel and Gabriel [2] and Gabriel, White and Bobrow [5]. Especially the notion of generic functions that are collections of methods, and the fact that it is the generic functions and not the methods that are called should be well understood. An understanding of the CLOS Metaobject Protocol (MOP) is not required it is only mentioned in notes that are not essential to the rest of the presentation.