Miracle-dz/UniFAR-FTUs huggingface dataset:
Maturation of digestive function is retarded and plasma antioxidant capacity lowered in fully weaned low birth weight piglets

The digestive function of low birth weight (LBW) pigs post-weaning has been poorly studied. Therefore, newborns from eleven hyperprolific sows were weighed, weaned at 27·2 d and fed a starter diet until sampling. Sampling was done between 18 and 28 d post-weaning. An LBW piglet (n 19) was defined as a piglet having a birth weight less than 1 kg and less than the lower quartile of litter birth weights. Normal birth weight (NBW) piglets (n 13) were having a birth weight close to the mean litter birth weight. For each piglet, eighty-eight variables were determined. Data were analysed with linear models with type of piglet and litter as predictors. A principal component analysis was performed to determine the most important discriminating variables. In the LBW pig, the development of the digestive tract post-weaning was delayed: lower small-intestinal weight:length ratio due to a thinner tela submucosa and tunica muscularis and a higher secretory capacity, both in the distal jejunum. These observations might be a consequence of lower circulating insulin-like growth factor-1 (IGF-1) concentrations (126 (se 10·0) v. 158 (se 12·0) ng/ml for LBW and NBW, respectively) and a lower density of IGF-1 receptors in the proximal small intestine. Additionally, the plasma antioxidant capacity was lower for the LBW pig. Taken together, in the LBW piglet, the normal gut maturation post-weaning was retarded and this did not seem to be related to the weaning transition as such.
A new, two-switch, isolated, three-phase AC-DC converter

In this paper, a new, three-phase, single-stage, isolated ac-dc converter (rectifier) that employs only two switches and achieves less than 5 % total harmonic distortion (THD) of the three-phase input currents and provides a tightly regulated, isolated, output voltage is introduced. The rectifier features zero-voltage-switching (ZVS) of both switches over the entire input and load range without any additional soft-switching circuitry. The rectifier is derived by combining the three-phase, frequency-controlled, power-factor-correction (PFC), discontinuous-current-mode (DCM) boost rectifier with the conventional LLC resonant half-bridge converter. The evaluation was performed on a 1-kW prototype operating with a three-phase line-voltage range from 180 VL-L to 264 VL-L and delivering a tightly-regulated, isolated, output voltage of 54 V.
QUARTZ CRYSTAL MICROBALANCE INVESTIGATION OF CELLULOSOME ACTIVITY FROM CLOSTRIDIUM THERMOCELLUM ON MODEL CELLULOSE FILMS

OF THESIS QUARTZ CRYSTAL MICROBALANCE INVESTIGATION OF CELLULOSOME ACTIVITY FROM CLOSTRIDIUM THERMOCELLUM ON MODEL CELLULOSE FILMS The cost of deconstructing cellulose into soluble sugars is a key impediment to the commercial production of lignocellulosic biofuels. The use of the quartz crystal microbalance (QCM) to investigate reaction variables critical to enzymatic cellulose hydrolysis is investigated here, extending previous studies of fungal cellulase activity for the first time to whole cell cellulases. Specifically, the activity of the cellulases of Clostridium thermocellum, which are in the form of cellulosomes, was investigated. To clearly differentiate the activity of free cellulosome and cell-bound cellulosome, the distribution of free cellulosome and cell-bound cellulosome in crude cell broth at different growth stages of C. thermocellum (ATCC 27405) was quantified. Throughout growth, greater than 70% of the cellulosome in the crude cell broth was unattached to the cell. The frequency response of the QCM was shown to capture adsorption and hydrolysis of amorphous cellulose films by the whole-cell cellulases. Further, both crude cell broth and free cellulosomes were found to have similar inhibition pattern (within 0 10 g/L cellobiose). Thus, kinetic models developed for the cell-free cellulosomes, which allow for more accurate interfacial adsorption analysis by QCM than their cell-attached counterparts, may provide insight into hydrolysis events in both systems.
Big Data and Named Entity Recognition Approaches for Urdu Language

Nowadays data is stored in digital form and Terabyte of data is generated on daily basis. It is diﬃcult task to extract useful information from Big data eﬃciently. From unstructured text Information extraction is a technique which used to extract information. Named Entity Recognition (NER) is an essential component of information extraction in the ﬁeld of Natural Language Processing (NLP). Further, Urdu language has various challenges to NER due to its agglutinative, inﬂectional nature and rich morphology. Therefore, NER systems for Urdu language are not mature yet due to lack of resources and ambiguities. This paper speciﬁcally addresses the diﬀerent approaches to NER and explore the existing work for NER in Urdu language.
Photosynthetic responses of young cashew plants to varying environmental conditions

O objetivo deste trabalho foi caracterizar as respostas das trocas gasosas de plantas jovens de cajueiro a densidade de fluxo de fotons fotossintetico (DFFF), temperatura, deficit de pressao de vapor (DPV) e concentracao interna de CO 2 (C i ), sob condicoes controladas. Cursos diarios das trocas gasosas e de variaveis de fluorescencia da clorofila a foram obtidos sob condicoes naturais. A taxa de assimilacao de CO 2 maxima foi de cerca de 13 mmol m -2 s -1 , com saturacao pela luz em torno de 1.000 mmol m -2 s -1 . As temperaturas das folhas entre 25 o C e 35 o C corresponderam a faixa otima para a fotossintese. Os estomatos mostraram-se sensiveis ao CO 2 e se fecharam com aumentos de C i . Aumentos do DPV exerceram pequeno efeito sobre a taxa de assimilacao de CO 2 , com uma pequena diminuicao acima de 2,5 kPa. Os estomatos, no entanto, foram fortemente afetados pelo DPV, com fechamento gradativo acima de 1,5 kPa. As condutâncias estomaticas, reduzidas em altos DPVs, foram eficientes em restringir as perdas de agua pela transpiracao e demonstraram adaptacao da especie a ambientes secos. Sob irradiância natural, a taxa de assimilacao de CO 2 apresentou saturacao no inicio da manha, variando posteriormente com as variacoes da DFFF. Decrescimos transientes da razao F v /F m foram registrados em torno de 11h, o que indica a ocorrencia de fotoinibicao. Decrescimos da eficiencia de captura da energia de excitacao, decrescimos da eficiencia efetiva do fotossistema II e aumentos da extincao nao-fotoquimica foram consistentes com a ocorrencia de fotoprotecao sob irradiância excessiva.
Mind-Body Therapies for African-American Women at Risk for Cardiometabolic Disease: A Systematic Review

Background A major determinant in cardiometabolic health is metabolic syndrome (MetS), a cluster of symptoms that portend the development of cardiovascular disease (CVD). As mind-body therapies are thought to help in lowering physiological and environmental CVD risk factors including blood pressure and psychological stress, they may also be beneficial for the primary prevention of CVD. Objectives To synthesize and summarize existing knowledge on the effectiveness of mind-body therapies on MetS outcomes in African-American (AA) women, a US subpopulation at high risk for CVD. Search Methods A systematic search of eight databases was conducted in order to identify published papers addressing the topic. We included trials involving AA adult women, ages 18–64, and we included RCTs that involved multifactorial interventions. Outcomes of interest were MetS, chronic disease, and CVD risk factors (blood pressure, blood lipids, blood glucose, BMI, waist circumference, and mental health domains). Two authors independently selected trials for inclusion, extracted data, and assessed risks of bias. Main Results We identified five trials for inclusion in this review. One study reported outcomes associated with the full MetS symptom cluster. The included trials were small, short term, and at high risk of bias. All interventions lasted at least 6 weeks.
DREAM Is Involved in the Genesis of Inflammation-Induced Prolabour Mediators in Human Myometrial and Amnion Cells

Preterm birth is the primary cause of perinatal morbidity and mortality worldwide. Inflammation induces a cascade of events leading to preterm birth by activating nuclear factor-κB (NF-κB). In nongestational tissues, downstream regulatory element antagonist modulator (DREAM) regulates NF-κB activity. Our aims were to analyse DREAM expression in myometrium and fetal membranes obtained at term and preterm and to determine the effect of DREAM inhibition on prolabour mediators in primary myometrial and amnion cells. DREAM mRNA expression was significantly higher in fetal membranes obtained after spontaneous labour compared to nonlabour and in amnion from women with histological preterm chorioamnionitis when compared to amnion from women without chorioamnionitis. In primary myometrial and amnion cells, the effect of DREAM silencing by siRNA was a significant decrease in the expression of proinflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, the adhesion molecule ICAM-1, MMP-9 mRNA expression and activity, and NF-κB transcriptional activity when stimulated with the proinflammatory cytokine IL-1β, the bacterial products fsl-1 or flagellin, or the viral dsRNA analogue poly(I:C). These data suggest that, in states of heightened inflammation, DREAM mRNA expression is increased and that, in myometrial and amnion cells, DREAM regulates proinflammatory and prolabour mediators which may be mediated via NF-κB.
Real-Time Coordinated Voltage Control of PV Inverters and Energy Storage for Weak Networks With High PV Penetration

There are more large-scale photovoltaic (PV) plants being established in rural areas due to availability of low-priced land. However, distribution grids in such areas traditionally have feeders with low X/R ratios, which makes the independent reactive power compensation method less effective on voltage regulation. Consequently, upstream step voltage regulator (SVR) may suffer from excessive tap operations with PV-induced fast voltage fluctuations. Although a battery energy storage system (BESS) can successfully smooth PV generation, frequent charge/discharge will substantially affect its cost effectiveness. In this paper, a real-time method is designed to coordinate PV inverters and BESS for voltage regulation. To keep up with fast fluctuations of PV power, this method will be executed in each 5 s control cycle. In addition, charging/discharging power of BESS is adaptively retuned by an active adjustment method in order to avoid BESS premature energy exhaustion in a long run. Finally, through a voltage margin control scheme, the upstream SVR and downstream PV inverters and BESS are coordinated for voltage regulation without any communication. This research is validated via a real-time digital simulator MatLab cosimulation platform, and it will provide valuable insights and applicable strategies to both utilities and PV owners for large-scale PV farm integration into rural networks.
Nipple Reduction With the Chullo-Hat Technique.

BACKGROUND Although various techniques of nipple reduction have been described in the literature, many are difficult to design or have unreliable outcomes. For men, as well as women who do not plan to breastfeed, it is not necessary to apply a complicated technique that protects the lactiferous ducts. OBJECTIVES The authors introduce a simple technique for nipple reduction that has achieved consistent, reproducible results. METHODS The desired nipple length is marked, and a chullo-hat excision pattern is drawn. After infiltration of a local anesthetic solution around the nipple, excision of the excess nipple tissue is performed, comprising 2 triangular flaps. The remaining 2 pillars are approximated with 5-0 Nylon simple interrupted sutures. However, the wound is not completely closed in the central area of the nipple, which promotes the drainage of discharge. RESULTS Fifty-three women (106 nipples) underwent this surgery between December 2009 and December 2013. The follow-up period ranged from 6 months to 2 years (mean, 10 months). No major complications occurred, and the scars were very inconspicuous. The postoperative appearance of nipples was consistently similar in size and shape. CONCLUSIONS This simple technique was safe and effective in nipples of different sizes. The results were reliable and consistent with expectations. Although this study included only women, the authors believe that outcomes would be successful in men as well. LEVEL OF EVIDENCE 4 Therapeutic.
Influence of the occlusal contacts in formation of Abfraction Lesions in the upper premolar

Objective: The aim of this study was to observe the influence of different occlusal contacts in a superior pre-molar structure using Finite Element Analysis. Material and Methods: A three-dimensional model of a superior pre-molar was designed to simulate three occlusion situations, namely central occlusion and two types of lateral occlusion contacts. The model presents enamel, dentin, a periodontal ligament and a fixation cylinder separately. All materials were considered isotropic, linear and homogeneous, and the contacts of each structure were perfectly bonded. On analysis software, a load was applied to an occlusal surface at 40° to the long axis on lateral contacts, and directed to the long axis on central occlusion contact. Results: The results were obtained in stress maps and the maximum values were then plotted in table for quantitative comparison, with the enamel concentrating more stress than dentin and the occlusal contact presenting the worst biomechanical behavior. Conclusion: Within the limitations of this study, it is possible conclude that: eccentric contacts have higher potential to develop abfraction lesions on the cervical region of teeth, thus increasing the magnitude of tensile and shear stresses. Keywords Finite Elements Analysis, Abfraction; Stress distribution; Occlusion, Premolar.
Reflections on integrated care from those working in and leading integrated respiratory teams*

Abstract The concept of integrated care has been advocated for many years to address some of the challenges faced by the NHS. This report examines the experiences of respiratory healthcare specialists working in an integrated role. Twelve qualitative telephone interviews were undertaken with a range of integrated respiratory specialists and their teams working in both hospitals and the community. A descriptive and thematic approach to data analysis was adopted. Participants were very enthusiastic about their roles and saw themselves as ambassadors for this new way of working. Several key themes were identified from the analysis which participants identified as barriers or enablers to the successful undertaking of an integrated respiratory specialist role. These included the participants’ previous work experience and background, the range of multi-disciplinary expertise within or needed for the team, the structure of the team leadership and the measurement of outcomes to evaluate the team. Participants identified the need for clear job descriptions and roles, shared training and standards and appropriate outcome evaluation. More research is needed to understand how these new ways of working are developing and how they can be evaluated.
Heat Extraction and Droplet Impact Regimes Obtained with Continuous Casting Air-mist Nozzles

This work presents experimental results about heat extraction and drop impact regimes taking place when a local portion of a horizontal flat-fan air-mist jet impinges a metallic disk maintained at temperatures of interest to continuous casting. The mists were generated with a nozzle operating under conditions of practical interest, and the disk was placed at center and off-center positions located along the major axis of the mist footprint. These conditions cover a wide spectrum of mist characteristics. The heat flux correlated very well with average properties of free non-impinging mists. Visualization of mist-wall interaction using a high speed camera, aided by laser illumination, reveals different droplet impact regimes that influence intensity, efficiency and uniformity of the cooling process.
Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes

Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal gynaecological malignancy in the Western world. Therapeutic approaches need to account for inter-patient and intra-tumoural heterogeneity and detailed characterization of in vitro models representing the different histological and molecular ovarian cancer subtypes is critical to enable reliable preclinical testing. There are approximately 100 publicly available ovarian cancer cell lines but their cellular and molecular characteristics are largely undescribed. We have characterized 39 ovarian cancer cell lines under uniform conditions for growth characteristics, mRNA/microRNA expression, exon sequencing, drug response for clinically-relevant therapeutics and collated all available information on the original clinical features and site of origin. We tested for statistical associations between the cellular and molecular features of the lines and clinical features. Of the 39 ovarian cancer cell lines, 14 were assigned as high-grade serous, four serous-type, one low-grade serous and 20 non-serous type. Three morphological subtypes: Epithelial (n = 21), Round (n = 7) and Spindle (n = 12) were identified that showed distinct biological and molecular characteristics, including overexpression of cell movement and migration-associated genes in the Spindle subtype. Comparison with the original clinical data showed association of the spindle-like tumours with metastasis, advanced stage, suboptimal debulking and poor prognosis. In addition, the expression profiles of Spindle, Round and Epithelial morphologies clustered with the previously described C1-stromal, C5-mesenchymal and C4 ovarian subtype expression profiles respectively. Comprehensive profiling of 39 ovarian cancer cell lines under controlled, uniform conditions demonstrates clinically relevant cellular and genomic characteristics. This data provides a rational basis for selecting models to develop specific treatment approaches for histological and molecular subtypes of ovarian cancer.
A review of the families, genera and species of Dicyemida Van Beneden, 1876

The classification of the species in the phylum Dicyemida Van Beneden, 1876, a group of small organisms whichparasitise the renal appendages of benthic cephalopods, is reviewed. While dicyemid parasites have simple multicellularmorphology, their lifecycle is complex and it is uncertain whether their affinities are with the protozoans or metazoans.Hence they are commonly given an intermediate ‘mesozoan’ status. Although 112 species are described, confusion existsfor 20% of the taxa over the validity of certain families, genera and species, which has been attributed to incomplete andinformation-poor descriptions, loss of type specimens, errors in taxonomy and conceptual differences. The history ofdicyemids dating from the first known reference by Filippo Calvolini of Italy in 1787 is presented, along with thecharacteristics which are commonly used to classify genera and species. All species described to date are listed withreference to the original published records and the validity of ambiguous records is explored. A way forward usingalternative technologies such as molecular genetic methods based on next generation sequencing platforms is suggested,which may help to address unresolved systematic and life history questions surrounding this parasite group. This review aims to assist taxonomists to help unravel the confusion surrounding the poorly studied and little understood Dicyemida.
Phosphorylation of Nodulin 26 on Serine 262 Affects Its Voltage-sensitive Channel Activity in Planar Lipid Bilayers (*)

Nodulin 26 is an symbiosome membrane protein of soybean nodules that shows ion channel activity in planar lipid bilayers. Serine 262 of nodulin 26 is phosphorylated by calmodulin-like domain protein kinase. To study the effects of phosphorylation, nodulin 26 with Ser, Ala, or Asp at position 262 were expressed in Escherichia coli. The expressed protein possessed a histidine-rich leader sequence for purification by Nichelate fast protein liquid chromatography. Upon reconstitution into planar lipid bilayers, the recombinant proteins showed a large single channel conductance (3.1 nanosiemens (nS) in cis/trans and 1.6 nS in cis/trans) and weak anion selectivity, similar to native soybean nodulin 26. Nodulin 26 with Ser- or Ala-262 occupied the maximal open conductance state greater than 97% of the time (3.1 nS in cis/trans) regardless of applied voltage. However, nodulin 26 with Asp-262 showed increased gating and preferential occupancy of lower subconductance states (1.8 and 0.6 nS in cis/trans) at high applied voltages (e.g. 70 mV). In situ phosphorylation of Ser-262 of nodulin 26 by calmodulin-like domain protein kinase also resulted in increased voltage-dependent gating and preferential occupancy of lower subconductance states. These results suggest that phosphorylation of serine 262 of nodulin 26 modulates channel activity by conferring voltage sensitivity.
A novel PUF based on cell error rate distribution of STT-RAM

Physical Unclonable Functions (PUFs) have been widely proposed as security primitives to provide device identification and authentication. Recently, PUFs based on Non-volatile Memory (NVM) are widely proposed since the promise of NVMs' wide application. In addition, NVM-based PUFs are considered to be more immune to invasive attack and simulation attack than CMOS-based PUFs. However, the existing NVM-based PUF either shows the unreliability under environmental variations or need extra modifications to the IC manufacturing process. In this work, we propose err-PUF, a novel PUF design based on the cell error rate distribution of STT-RAM. Instead of using the distribution directly, we generate a stable fingerprint based on a novel concept called Error-rate Differential Pair (EDP) without modifications to the read/write circuits. Comprehensive results demonstrate that err-PUF can achieve sufficient reliability under environmental variations, which can significantly impact the cell error rates. Moreover, compared with existing approaches, err-PUF has a higher speed and lower power consumption with negligible overhead.
Comparison of Structure and Dynamics of Micelle-bound Human α-Synuclein and Parkinson Disease Variants*

Three point mutations (A30P, E46K, and A53T) as well as gene triplication genetically link the 140-residue protein α-synuclein (aS) to the development of Parkinson disease. Here, the structure and dynamics of micelle-bound aS(A30P) and aS(A53T) are described and compared with wild-type aS, in addition to describing the aS-micelle interaction. A53T is sensed only by directly adjacent residues and leaves the backbone structure and dynamics indistinguishable from the wild type. A30P interrupts one helix turn (Val26–Ala29) and destabilizes the preceding one. A shift in helix register following A30P disturbs the canonical succession of polar and hydrophobic residues for at least two turns. The shortened helix-N adopts a slightly higher helical content and is less bent, indicating that strain was present in the micelle-bound helix. In the vicinity of the A30P-induced perturbations, the underlying micelle environment has rearranged, but nevertheless all aS variants maintain similar interrelationships with the micelle. Moreover, aS-micelle immersion correlates well with fast and slow aS backbone dynamics, allowing a rare insight into protein-micelle interplay.