Miracle-dz/UniFAR-FTUs huggingface dataset:
Reducing anxiety sensitivity with exercise

Background: Exercise interventions repeatedly have been shown to be efficacious for the treatment of depression, and initial studies indicate similar efficacy for the treatment of anxiety conditions. To further study the potential beneficial role of prescriptive exercise for anxiety‐related conditions, we examined the role of exercise in reducing fears of anxiety‐related sensations (anxiety sensitivity). Methods: We randomly assigned 60 participants with elevated levels of anxiety sensitivity to a 2‐week exercise intervention, a 2‐week exercise plus cognitive restructuring intervention, or a waitlist control condition. Assessment of outcome was completed at pretreatment, midtreatment, 1‐week posttreatment, and 3‐week follow‐up. Results: We found that both exercise conditions led to clinically significant changes in anxiety sensitivity that were superior to the waitlist condition, representing a large controlled effect size (d=2.15). Adding a cognitive component did not facilitate the effects of the exercise intervention. Consistent with hypotheses, changes in anxiety sensitivity mediated the beneficial effects of exercise on anxious and depressed mood. Conclusions: We discuss these findings in terms of the potential role of exercise as an additional psychosocial intervention for conditions such as panic disorder, where anxiety sensitivity is a prominent component of pathology. Depression and Anxiety 25:689–699, 2008. © 2008 Wiley‐Liss, Inc.
Research on the Financial Risk Evaluation of Listed Coal Companies Based on Entropy TOPSIS Method

The coal industry is a pillar industry in China. It is very important for risk assessment of listed companies in the coal industry. Selecting 24 listed companies in the coal industry in China as the research object, build risk assessment indicators for listed coal companies from five aspects: debt-paying ability, profitability, operational ability, development ability, and cash flow ability, and use entropy weight method and TOPSIS method to calculate the weight of each index, finally calculated the closeness and ranking of each listed company and the best plan, and provided guidance for the risk management of coal enterprises.
Early Correlated Network Activity in the Hippocampus: Its Putative Role in Shaping Neuronal Circuits

Synchronized neuronal activity occurring at different developmental stages in various brain structures represents a hallmark of developmental circuits. This activity, which differs in its specific patterns among animal species may play a crucial role in de novo formation and in shaping neuronal networks. In the rodent hippocampus in vitro, the so-called giant depolarizing potentials (GDPs) constitute a primordial form of neuronal synchrony preceding more organized forms of activity such as oscillations in the theta and gamma frequency range. GDPs are generated at the network level by the interaction of the neurotransmitters glutamate and GABA which, immediately after birth, exert both a depolarizing and excitatory action on their targets. GDPs are triggered by GABAergic interneurons, which in virtue of their extensive axonal branching operate as functional hubs to synchronize large ensembles of cells. Intrinsic bursting activity, driven by a persistent sodium conductance and facilitated by the low expression of Kv7.2 and Kv7.3 channel subunits, responsible for IM, exerts a permissive role in GDP generation. Here, we discuss how GDPs are generated in a probabilistic way when neuronal excitability within a local circuit reaches a certain threshold and how GDP-associated calcium transients act as coincident detectors for enhancing synaptic strength at emerging GABAergic and glutamatergic synapses. We discuss the possible in vivo correlate of this activity. Finally, we debate recent data showing how, in several animal models of neuropsychiatric disorders including autism, a GDPs dysfunction is associated to morphological alterations of neuronal circuits and behavioral deficits reminiscent of those observed in patients.
Nominal and Robust Loop Shaping

In this paper, classical frequency-response multivariable comnpensator design is studied. This problem consists of chosing a linear controller which gives the sensitivity and complementary sensitivity functions desirable properties. The problem is given two formulations as optimal multivariable stability margin (km) synthesis (or ¿-synthesis, robustness margin synthesis) problems, thereby establishing the consistency with and unification of the present problem with modern robust control theory. These formulations are termed the nominal and the robust loop shaping problems. A quantitative assessment of how well the standard H¿-theory performs in this context is given for the multivariable case, using new bounds. The primary conclusion is that the existing H¿-theory does surprisingly well in handling multivariable problems with classical frequency response specifications.
Low Energy Intracardiac Cardioversion of Persistent Atrial Fibrillation

The aims of the study were to verify the efficacy and safety of low energy internal Cardioversion (LEIC) in patients with persistent at rial fibrillation (AF) and to identify the factors affecting the at rial defihrillation threshold (ADT). Forty‐nine patients with persistent (lasting ≥ 10 days) AF underwent LEIC. In each patient, two 6 Fr custom‐made catheters with large active surface areas were positioned in the coronary sinus (cathode) and the lateral right wall (anode), respectively, for shock delivery, and a tetrapolar lead was placed in the fight ventricular apex for R wave synchronization. Truncated, biphasic (3 ms+3 ms). exponential shocks were used, beginning at 50 V and increasing in steps of 50 V until sinus rhythm had been restored. Mild sedation (diazepam 5 mg IV) was administered to 12 patients. Sinus rhythm was restored in all the subjects with mean voltage and energy levels of 352.0 ± 80.3 V and 8.2 ± 3.4 J, respectively. The ADT in patients pretreated with amiodarone (6.4 ± 1.8 J) was lower than that of patients who had not received any antiarrhythmic drugs (9.2 ± 3.7) (P = 0.04). No ventricular arrhythmias were induced by any of the atrial shocks, and no other complications were observed. During a mean follow‐up of 162.9 ± 58.7 days, AF recurred in 21 (43%) patients; 71% of these occurred in the first week after Cardioversion. LEIC is effective in restoring sinus rhythm in patients with persistent AF. The technique seems to be safe and does not require general anesthesia or, in most cases, sedation. Patients pretreated with amiodarone have lower ADTs.
Resilience of Malaysian Public Sector Construction Industry to Supply Chain Disruptions

The uncertainty and complexity of the interdependent global economy have amplified collective exposure of supply chains to disruptive events. In the construction world, the fragmented nature of the temporary project teams and the uncertain operating environment make construction supply chains more vulnerable to these disruptive events. In Malaysia, the construction industry has become the focal point for development through the Government’s “Malaysia Vision 2020” transformation programme, in the effort to become a developed country by the year 2020. However, despite good plans for the development of public projects, the Malaysian Auditor General Report 2014 identified several weaknesses in the delivery of construction projects that caused poor project performance. The dynamics and effects of interconnected risks among construction organisations tend to be overlooked across the Malaysian public project supply chains, making them highly vulnerable to supply chain disruptions. This calls for the need to go beyond the traditional silo approach of the risk management process. This research aims to investigate the Malaysian public sector supply chain’s resilience capabilities and vulnerabilities in handling disruptions in the effort to build supply chain resilience against disruptions and improve the delivery of public projects. A comprehensive questionnaire survey was conducted with 105 construction professionals from two groups of respondents, the public and private organisations in the public sector supply chain to identify their current vulnerabilities and capabilities. Data were analysed using descriptive statistics and compared using the Mann-Whitney U and Kruskal-Wallis tests. The findings revealed that the public organisations faced significantly higher political threats whilst the private organisations faced significant market pressures. Subsequent semistructured interviews were conducted with 12 professionals in the field to identify the inherent pathogens that make the supply chain highly vulnerable in these critical areas. The emergent pathogenic influences include practice, circumstance, convention, organisation and behavior. Finally, a resilience response framework was developed based on the triangulation of these results. The framework allows the experts from the public sector supply chain to understand the critical vulnerabilities and pathogenic influences of their organisation and their supply chain members, along with the set of capabilities to reduce the disruptive impacts arising from these critical vulnerabilities.
A new target for the old regulator: H‐NS suppress T6SS secretory protein EvpP, the major virulence factor in the fish pathogen Edwardsiella tarda

The evpP gene in fish pathogen Edwardsiella tarda, coding the T6SS secretory protein EvpP and carrying an evpA‐evpO independent promoter region, was crucial for host cell invasion. The transcription of evpP was positively regulated by either the two‐component system EsrA‐EsrB or iron concentration, and its overexpression was known to enhance the invasion ability in our previous study. This work demonstrated that the H‐NS protein, a pleiotropic regulator of gene expression, was a new transcriptional modulator of evpP gene. The results showed that in vivo the transcriptional level of evpP was downregulated by H‐NS and in vitro this global regulator interacted directly with evpP promoter region. Moreover, DNase I footprinting experiments mapping the interaction regions of H‐NS and evpP revealed that this global regulator bound to evpP promoter and neighbouring areas at multiple sites. We provided a new insight into evpP regulation network and demonstrated the repression of H‐NS to the transcription of evpP gene.
Supporting customer retention through analytics in banking industry

Author Riikka Säynätjoki Title Supporting customer retention through analytics in banking industry School LUT School of Business and Management Master’s Program International Marketing Management Year 2019 Master’s Thesis Lappeenranta University of Technology 108 pages, 1 figure, 8 tables, 2 appendices Examiners Associate Professor Anssi Tarkiainen Professor Sanna-Katriina Asikainen
Independent Validation of a Prognostic Genomic Signature (ColoPrint) for Patients With Stage II Colon Cancer

Objectives:The aim of this study was to independently validate a genomic signature developed both to assess recurrence risk in stage II patients and to assist in treatment decisions. Background:Adjuvant therapy is recommended for high-risk patients with stage II colon cancer, but better tools to assess the patients' prognosis accurately are still required. Methods:Previously, an 18-gene signature had been developed and validated on an independent cohort, using full genome microarrays. In this study, the gene signature was translated and validated as a robust diagnostic test (ColoPrint), using customized 8-pack arrays. In addition, clinical validation of the diagnostic ColoPrint assay was performed on 135 patients who underwent curative resection (R0) for colon cancer stage II in Munich. Fresh-frozen tissue, microsatellite instability status, clinical parameters, and follow-up data for all patients were available. The diagnostic ColoPrint readout was determined blindly from the clinical data. Results:ColoPrint identified most stage II patients (73.3%) as at low risk. The 5-year distant-metastasis free survival was 94.9% for low-risk patients and 80.6% for high-risk patients. In multivariable analysis, ColoPrint was the only significant parameter to predict the development of distant metastasis with a hazard ratio of 4.28 (95% confidence interval, 1.36–13.50; P = 0.013). Clinical risk parameters from the American Society of Clinical Oncology (ASCO) recommendation did not add power to the ColoPrint classification. Technical validation of ColoPrint confirmed stability and reproducibility of the diagnostic platform. Conclusions:ColoPrint is able to predict the development of distant metastasis of patients with stage II colon cancer and facilitates the identification of patients who may be safely managed without chemotherapy.
Comparison of the OH (8-3) and (6-2) band rotational temperature of the mesospheric airglow emissions

The airglow OH (8-3) and (6-2) band rotational temperatures were measured and compared using two scanning photometer at Cachoeira Paulista (23oS, 45oW) in 1999. The rotational temperature were obtained from the ratio between the P1(5) and P1(3) in the case of the (8-3) band and P1(4) and P1(2) lines for the (6-2) band. Three different Einstein coefficients, of Mies (1974), Langhoff et al., (1986) and Turnbull & Lowe (1989) were used and compared between them. It was shown that both the temperature did agree well with in an error range when the Langhoff et al.'s coefficients were used.
Excessive Fall of Blood Pressure During Maintenance Hemodialysis in Patients With Chronic Renal Failure Is Induced by Vascular Malfunction and Imbalance of Autonomic Nervous Activity

Acute hypotension during maintenance hemodialysis (HD) is not only a critical complication, but also an independent risk factor for mortality in patients with chronic renal failure (CRF). This study was designed to clarify the mechanisms underlying excessive fall of blood pressure during HD. Fifty‐six CRF patients with HD thrice a week were divided into two groups according to the intradialytic hypotension episodes after 4 weeks of the observation period; the hypotension group, showing four or more episodes of intradialytic hypotension, and the non‐hypotension group, showing three episodes of intradialytic hypotension or less. The intradialytic hypotension was defined as a fall of ≥30 mm Hg in the systolic blood pressure during HD. The brachial‐ankle pulse wave velocity (ba‐PWV), serum high‐sensitivity (hs)‐CRP, reactive oxygen species (ROS) generation, and serum malondialdehyde‐modified LDL (MDA‐LDL) were measured before HD. The high‐ frequency (HF) and low‐frequency components (LF) of the heart rate variability and entropy were analyzed by the maximal entropy method. The ba‐PWV, hs‐CRP, ROS generation, and MDA‐LDL were significantly higher in the hypotension group than in the non‐hypotension group. HF, LF/HF, and entropy during HD increased significantly in the non‐hypotension group, while entropy during HD decreased significantly in the hypotension group as compared with the baseline. LF/HF and entropy during HD were significantly lower in the hypotension group than in the non‐hypotension group. These findings suggest that the major factors causing excessive fall of blood pressure during HD in patients with CRF might be vascular malfunction and imbalance of autonomic nervous activity.
Dairy Cattle Mortality Management via Anaerobic Digestion

With the decline in the number of rendering operations due to industry consolidation and concern about Bovine Spongiform Encephalopathy (BSE) transmission, disposal of dairy and beef cattle mortalities by rendering either is not an option or is prohibitively expensive in many areas of the United States. On-site burial remains an alternative in many states, but impact on ground water quality is of concern. Many landfill operators either refuse to accept livestock mortalities for disposal, or the cost is difficult for producers to absorb. Incineration, an option for carcass disposal, has high investment and operating costs and is complicated by regulatory compliance issues. Another disposal alternative is co-composting with a carbonaceous material such as sawdust or straw. However, both incineration and composting generally are more suitable for the disposal of small animal mortalities such as those from poultry operations.
ESTIMAÇÃO ESPACIAL DA MIGRAÇÃO DE CONSUMIDORES RESIDENCIAIS PARA A TARIFA BRANCA EM SISTEMAS DE DISTRIBUIÇÃO DE ENERGIA ELÉTRICA

Neste trabalho o espaco geografico e incorporado ao estudo da analise das potencialidades de migracao de consumidores residenciais para uma nova opcao tarifaria: a tarifa branca. Os trabalhos avaliados no tema nao incorporam a analise espacial de dados geograficos. Em geral apresentam as classes de consumo que mais se beneficiam com a adocao da nova opcao tarifaria e aspectos relacionados a estrutura tarifaria de energia eletrica no Brasil. No entanto, o estudo das caracteristicas do lugar onde pode ser mais provavel a migracao massiva de consumidores para a tarifa branca pode trazer informacoes relevantes para direcionar a atencao das distribuidoras de energia na aquisicao de medidores eletronicos e outros equipamentos para determinadas regioes da cidade. Promove-se dessa forma um melhor dimensionamento do sistema eletrico. Os resultados deste trabalho sao mapas de probabilidades uteis para indicar as subareas onde ha maior probabilidade de migracao de consumidores para a tarifa branca. Esses mapas indicam que algumas regioes da cidade como a porcao central e leste para os anos de 2018 e 2019 exibem maior probabilidade de unidades consumidoras aptas a migrarem para a tarifa branca. Portanto, ha nessas regioes uma tendencia de reducao da demanda de ponta (ou de pico).
Health-related quality of life in children with moderate-to-severe traumatic brain injury

Objective: To investigate health-related quality of life (HRQOL) in a sample of ethnically diverse children with traumatic brain injury (TBI). Methods: Twenty children with moderate–severe TBI and their parents were recruited from a TBI clinic at a paediatric rehabilitation hospital. Children's self-reported HRQOL was assessed with the Pediatric Quality of Life Inventory. Parents completed a parallel proxy measure. Results: Children reported significantly lower Psychosocial HRQOL compared to their Total HRQOL, driven largely by low School HRQOL scores. Compared to other paediatric populations, children with TBI reported lower or equivalent HRQOL. Compared with children's self-reports, parents reported even lower HRQOL for their children across primary domains, with fair-to-moderate convergence between informants. Conclusions: Results provide preliminary evidence that children who have suffered moderate–severe TBI experience relatively poor HRQOL, particularly in the School domain. Limited convergence between informants suggests that children and parents perceive HRQOL differently, with parents reporting lower HRQOL.
Effect of a Combination of Mild-Temperature Hyperthermia and Nicotinamide on the Radiation Response of Experimental Tumors

Abstract Ogawa, A. , Griffin, R. J. and Song, C. W. Effect of a Combination of Mild-Temperature Hyperthermia and Nicotinamide on the Radiation Response of Experimental Tumors. The effect of mild-temperature hyperthermia and nicotinamide individually or combined on tumor radiosensitivity was investigated with SCK tumors grown s.c. in the right hind limbs of A/J mice. An i.p. injection of nicotinamide at 50–250 mg/kg slightly enhanced the cell killing caused by 10–20 Gy of ionizing radiation as determined by the in vivo/in vitro tumor excision assay. Treatment of tumors with mild-temperature hyperthermia at 41.5°C for 60 min prior to tumor irradiation was significantly more effective than nicotinamide and the combination of nicotinamide and hyperthermia was far more effective than nicotinamide or hyperthermia alone in enhancing radiation-induced cell killing. Radiation-induced tumor growth delay was enhanced by a factor of 1.2 by 50 mg/kg nicotinamide, 2.1 by hyperthermia, and 3.6 by the combination of nicotinamide and hyperthermia. Taking these results and those of our previous studies together, we conclude that mild-temperature hyperthermia increases tumor blood flow and oxygenation and that combining mild-temperature hyperthermia and nicotinamide is more effective than either of these alone in increasing tumor radiosensitivity.
A New Transparent Way to Perform Competition, Market Structure and IPR Portfolio Analyses: Analysis of the Dynamics of Trademark Competition in Finland as a Case Example

The paper presents a new way to perform IPR portfolio analyses (trademark and patent analyses) and other market structure analyses. Trademark and patents analyses become more significant for the development of companies, especially in current conditions of technological disruption. We will reflect (1) current STI management and foresight, (2) most important IT technology trends for year 2017 and (3) the most evaluated technologies in the Gartner HC evaluations. Trademark analyses and especially novel LKI analysis can contribute to capturing relevant aspects of market and technology disruptions. Our demonstration is focused on trade marking and trademark registrations in Finland. The LKI analysis is scientifically as generic as Herfindahl-Hirchman Index (HHI) has been during its long history of indicator research. LKI approach makes us free from the scaling problems of conventional HHI. IPR portfolios with any size can now be analysed without potential statistical biases. We develop and introduce the HHI index and a new IPR and market analysis index: LKI (Lauraeus-Kaivo-oja Index). The evaluation results of the HHI analysis and the LKI analysis are compared. With the LKI, we are able to compare better the substance of Intellectual Property Right (IPR) portfolios and market structures. Furthermore, we show, why percentage numbers are easier to comprehend than HHI index points.
The language components in Verbmobil

This paper gives an overview of the main problems and their solutions in the language components of the Verbmobil speech translation system. Interpretation of spontaneously spoken language has to take into account that syntax and semantics differ from written language, that punctuation is missing, that accent and intonation have effects on the meaning and the translation, that the output of the speech recognizer may be noisy and that speakers produce errors due to distraction. The Verbmobil interpretation and translation components try to attack these problems by means of a grammar for spoken language, heavy use of prosodic information, a syntactic search on word hypothesis graphs and a shallow robust fall back translation device that is used in case the "deep" translation fails.
Safety of Outpatient Airway Dilation for Adult Laryngotracheal Stenosis

Objectives: To evaluate the safety of outpatient airway dilation for adult patients with subglottic or tracheal stenosis. Methods: The records of patients treated with airway dilation between October 2003 and September 2013 were reviewed. Outcomes of patients who underwent dilation as inpatients versus outpatients were compared. Emergency room visits, readmissions, and 3 or more primary care physician visits within 30 days postoperatively were specifically evaluated. Postoperative hemorrhage, airway edema, recurrent laryngeal nerve paralysis, reintubation, tracheostomy, tracheal rupture, pneumomediastinum, pneumothorax, acute respiratory distress, or death were also reviewed. Results: One hundred fourteen dilations performed in 53 patients with airway stenosis were included. Outpatient dilation was performed in 93 (82%); 21 (18%) underwent the procedure in the inpatient setting. Complications were low among both inpatient and outpatient groups (10% vs 1%, P = .09). No complications occurred during the overnight stay of the inpatient group. Conclusions: Outpatient airway dilation is a safe and feasible procedure. It can be routinely performed on an ambulatory basis.