Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhancing early childhood outcomes: connecting child welfare and Head Start

Head Start is a preschool program for families with low incomes and nearly 85% of child welfare-involved families are low-income, yet little is known about Head Start and child welfare collaboration. This study uses data from 28 Head Start directors to describe collaboration facilitators and barriers, and collaborative mechanisms in place. The mixed-methods study used data from a statewide survey and focus groups. Quantitative analysis used descriptive means and proportions. Qualitative analysis used a general inductive approach. Results show that nearly all Head Start programs prioritise enrollment for child welfare-involved children and know about foster care placement, but lack memoranda of understanding (50%), co-located staff (14%) and policies concerning joint service planning (9%). Directors report that Head Start staff need more support, including making referrals to child welfare. Cross-training, shared case planning, and streamlined processes could help move the organisations further along the developmental continuum of collaboration.
Anatomy of the AGN in NGC 5548 VIII. XMM-Newton's EPIC detailed view of an unexpected variable multilayer absorber

In 2013, we conducted a large multi-wavelength campaign on the archetypical Seyfert 1 galaxy NGC 5548. Unexpectedly, this usually unobscured source appeared strongly absorbed in the soft X-rays during the entire campaign, and signatures of new and strong outflows were present in the almost simultaneous UV HST/COS data. Here we carry out a comprehensive spectral analysis of all available XMM-Newton observations of NGC 5548 (precisely 14 observations from our campaign plus three from the archive, for a total of ~763 ks) in combination with three simultaneous NuSTAR observations. We obtain a best-fit underlying continuum model composed by i) a weakly varying flat (Γ ~ 1.5-1.7) power-law component; ii) a constant, cold reflection (FeK + continuum) component; iii) a soft excess, possibly owing to thermal Comptonization; and iv) a constant, ionized scattered emission-line dominated component. Our main findings are that, during the 2013 campaign, the first three of these components appear to be partially covered by a heavy and variable obscurer that is located along the line of sight (LOS), which is consistent with a multilayer of cold and mildly ionized gas. We characterize in detail the short timescale (mostly ~ks-to-days) spectral variability of this new obscurer, and find it is mostly due to a combination of column density and covering factor variations, on top of intrinsic power-law (flux and slope) variations. In addition, our best-fit spectrum is left with several (but marginal) absorption features at rest-frame energies ~6.7-6.9 keV and ~8 keV, aswell as a weak broad emission line feature redwards of the 6.4 keV emission line. These could indicate a more complex underlying model, e.g. a P-Cygni-type emission profile if we allow for a large velocity and wide-angle outflow. These findings are consistent with a picture where the obscurer represents the manifestation along the LOS of a multilayer of gas, which is also in multiphase, and which is likely outflowing at high speed, and simultaneously producing heavy obscuration and scattering in the X-rays, as well as broad absorption features in the UV.
Clozapine in the Treatment of Newly Admitted Schizophrenic Patients A Pilot Study

cals, New Jersey. It has been reported that clozapine has au ant ipsychotie effect1; and it seems that its extrapyramidal spectrum may differ from that of the classical neuroleptics in that it induces tremors and hypersalivation, while rarely causing dystonic reactions, akathisia, or rigidity. Other side effects such as drowsiness and hypotension have been noted. The basic advantages of this antipsychotic drug are its apparent absence of extrapyramidal side effects, such as rigidity, and the possibility that tardive dyskinesia is not induced. The purpose of this study, which was carried out in a Brief Therapy Unit, was to evaluate the effect of clozapine in the treatment of newly admitted schizophrenic patients. The Brief Therapy Unit was chosen so that the relative efficacy of elozapine could be evaluated in a shortterm setting, the main advantage of which is that the patient can be sent back into the community without a lengthy hospitalization period. Since the study was not double blind, it was decided that all patients would be evaluated by two psychiatrists. A total of five psychiatrists participated in the study.
Safety cases: A review of challenges

In this article, we address safety cases as special cases of the more general class of assurance cases, which were developed as an extension to the concept of safety case. Related to the development and use of safety cases, there remain challenges, such as their size, readability, and identifying fallacious reasoning used in arguments. Some of these challenges are reviewed in the current article and followed by a review of challenges for the assessment of safety cases by regulators.
RISPERIDONE-INDUCED NEUROLEPTIC MALIGNANT SYNDROME : A CASE REPORT

A young male schizophrenic presented with neuroleptic malignant syndrome (NMS). Risperidone was the probable precipitating agent. Rigidity and elevated CPK levels poorly responded to bromocriptine, but showed good response to dantrolene. The role of specific treatment and the differential response of the symptom clusters are discussed.
Genome-Wide Association Study to Characterize Serum Bilirubin Elevations in Patients with HCV Treated with Gs-9256, An HCV Ns3 Serine Protease Inhibitor

Background Protease inhibitors for the treatment of HCV can cause mild and reversible elevations of unconjugated bilirubin. We sought to characterize genetic determinants of bilirubin elevations using a genome-wide approach among patients with genotype 1 HCV who received combination therapy that included GS-9256, a novel potent inhibitor of HCV NS3 serine protease, as part of a Phase IIb trial. Methods Of the 200 patients sampled, 176 had confirmed European ancestry and were included in the analysis. Infinium HumanOmni5BeadChip (Illumina, Inc., San Diego, CA, USA) was used for genotyping. A categorical analysis of low (grade 0–1) versus high (grade 2–4) bilirubin toxicity grade and a quantitative trait locus mapping of peak bilirubin concentrations was performed. Results A total of 4,466,809 genetic markers were analysed. No single variant showed a statistically significant association with observed bilirubin elevations in this patient population. In a targeted analysis of single nucleotide polymorphisms in genes known to be involved in bilirubin transport, no significant differences in allele frequency between high and low bilirubin toxicity grade were observed. Conclusions These results indicate that risk for bilirubin elevation in patients receiving GS-9256 is unlikely to be strongly influenced by common genetic variants with large effects. The current study cannot rule out a role for common variants of weak effect, or a more complex model, including multiple contributing factors, such as rare variants and as yet unidentified environmental influences.
Classroom Strategies for Teaching Veterans with Post-Traumatic Stress Disorder and Traumatic Brain Injury.

Postsecondary institutions currently face the largest influx of veteran students since World War II. As the number of veteran students who may experience learning problems caused by Post-Traumatic Stress Disorder and/or Traumatic Brain Injury continues to rise, the need for instructional strategies that address their needs increases. Educators may unwittingly expose these students to uncomfortable or distressing situations. Equipped with basic knowledge about the brain and memory, college faculty can provide instruction and assessment in ways that allow all students in the classroom to feel successful, including “wounded warriors. ” This article provides suggestions for research-supported strategies that postsecondary faculty can use to promote wider access for an increasingly diverse student population.
When Collaboration Becomes a Struggle

Purpose: In this study a collaboration project in Swedish youth care is analysed. The aim of the project was to enhance coordination between the Social Services and the Swedish National Board of Institutional Care in order to make the efforts more efficient. The project also employed a number of coordinators. The overall purpose of this study is to analyse conflicts, alliances and comparisons identifiable in interviews and observations. The analytic findings are put into an overall “collaboration context” represented by earlier research on the social phenomenon of “collaboration”. In this way the study tries to contribute to a sociological understanding of a contemporary widespread phenomenon.
Polynomial Solution of Sylvester Matrix Equation

LetMn(K) (resp. M(n;m)(K)) be the ring of all square n n (resp. of all rectangular n m ) matrices with entries from a eld K. Let A 2 Mn(K), B 2 Mm(K) and C 2 M(n;m)(K). The Sylvester matrix equation (SME)
Inferring protein-protein interaction networks from protein complex data

Present day approaches for the determination of protein-protein interaction networks are usually based on two hybrid experimental measurements. Here we consider a computational method that uses another type of experimental data: instead of direct information about protein-protein interactions, we consider data in the form of protein complexes. We propose a method for using these complexes to provide predictions of protein-protein interactions. When applied to a dataset obtained from a cat melanoma cell line we find that we are able to predict when a protein pair belongs to a complex with approximately 96% accuracy. Further, we are able to extrapolate the experimentally identified interaction pairs to the entire cat proteome.
Learning visual categories through a sparse representation classifier based cross-category knowledge transfer

To solve the challenging task of learning effective visual categories with limited training samples, we propose a new sparse representation classifier based transfer learning method, namely SparseTL, which propagates the cross-category knowledge from multiple source categories to the target category. Specifically, we enhance the target classification task in learning a both generative and discriminative sparse representation based classifier using pairs of source categories most positively and most negatively correlated to the target category. We further improve the discriminative ability of the classifier by choosing the most discriminative bins in the feature vector with a feature selection process. The experimental results show that the proposed method achieves competitive performance on the NUS-WIDE Scene database compared to several state of the art transfer learning algorithms while keeping a very efficient runtime.
Load-induced changes in bone stiffness and cancellous and cortical bone mass following tibial compression diminish with age in female mice

The vertebrate skeleton is an adaptive structure that responds to mechanical stimuli by increasing bone mass under increased mechanical loads. Although experimental animal models have shown the anabolic cortical bone response to applied load decreases with age, no consensus exists regarding whether this adaptive mechanism is affected by age in cancellous bone, the tissue most impacted by age-related bone loss. We used an established murine in vivo tibial loading model to characterize the load-induced cancellous, cortical and whole-bone responses to mechanical stimuli in growing and mature female mice at 6, 10 and 16 weeks of age. The effects of applied load on tibial morphology and stiffness were determined using microcomputed tomography and in vivo bone strains measured at the medial tibial midshaft during applied loading. At all ages, 2 weeks of applied load produced larger midshaft cortical cross-sectional properties (+13–72%) and greater cancellous bone volume (+21–107%) and thicker trabeculae (+31–68%) in the proximal metaphyses of the loaded tibiae. The relative anabolic response decreased from 6 to 16 weeks of age in both the cancellous and cortical envelopes. Load-induced tibial stresses decreased more in 6-week-old mice following loading, which corresponded to increased in vivo tibial stiffness. Stiffness in the loaded tibiae of 16-week-old mice decreased despite moderately increased cortical cross-sectional geometry, suggesting load-induced changes in bone material properties. This study shows that the cancellous and cortical anabolic responses to mechanical stimuli decline with age into adulthood and that cortical cross-sectional geometry alone does not necessarily predict whole-bone functional stiffness.
A Qualitative Assessment of "The Men's Program:" The Impact of a Rape Prevention Program on Fraternity Men

This qualitative study examined the impact of an all-male rape prevention program on fraternity men. Seven months after participating in “The Men’s Program,” fraternity men were asked whether during the previous year the program impacted their attitude or behavior and if so what about the program led to that change. Results point to the importance of establishing empathy with rape survivors to increase men’s awareness and sensitivity to rape.
Social Literacies: Critical Approaches to Literacy in Development, Ethnography and Education

Acknowledgements Introduction Section 1: Literacy, Politics and Social Change Introduction 1 Putting Literacies on the Political Agenda 2 Literacy and Social Change: The Significance of Social Context in the Development of Literacy Programmes Section 2: The Ethnography of Literacy Introduction 3. The Uses of Literacy and Anthropology in Iran 4. Orality and Literacy as Ideological Constructions: Some Problems in Cross-cultural Studies Section 3. Literacy in Education Introduction 5. The Schooling of Literacy 6. The Implications of the New Literacy Studies for Pedagogy Section 4: Towards a Critical Framework Introduction 7. A critical Look at Walter Ong and the `Great Divide' 8. Literacy Practices and Literacy Myths Index
Test–Retest Reliability of Self-Reported Sexual Behavior History in Urbanized Nigerian Women

Background Studies assessing risk of sexual behavior and disease are often plagued by questions about the reliability of self-reported sexual behavior. In this study, we evaluated the reliability of self-reported sexual history among urbanized women in a prospective study of cervical HPV infections in Nigeria. Methods We examined test–retest reliability of sexual practices using questionnaires administered at study entry and at follow-up visits. We used the root mean squared approach to calculate within-person coefficient of variation (CVw) and calculated the intra-class correlation coefficient (ICC) using two way, mixed effects models for continuous variables and (κ^) statistics for discrete variables. To evaluate the potential predictors of reliability, we used linear regression and log binomial regression models for the continuous and categorical variables, respectively. Results We found that self-reported sexual history was generally reliable, with overall ICC ranging from 0.7 to 0.9; however, the reliability varied by nature of sexual behavior evaluated. Frequency reports of non-vaginal sex (agreement = 63.9%, 95% CI: 47.5–77.6%) were more reliable than those of vaginal sex (agreement = 59.1%, 95% CI: 55.2–62.8%). Reports of time-invariant behaviors were also more reliable than frequency reports. The CVw for age at sexual debut was 10.7 (95% CI: 10.6–10.7) compared with the CVw for lifetime number of vaginal sex partners, which was 35.2 (95% CI: 35.1–35.3). The test–retest interval was an important predictor of reliability of responses, with longer intervals resulting in increased inconsistency (average change in unreliability for each 1 month increase = 0.04, 95% CI = 0.07–0.38, p = 0.005). Conclusion Our findings suggest that overall, the self-reported sexual history among urbanized Nigeran women is reliable.
NeuCloud: Enabling Privacy-preserving Monitoring in Cloud Computing

Cloud computing has changed how services are provided and supported through the computing infrastructure. However, the lack of trust from both sides - the client and the cloud provider, is still a major obstacle to prevent many users from using the cloud, especially for users who are very concerned about the privacy of their computing and data in the cloud. There has been little research on architectures designed to monitor client VMs while preserving their privacy in cloud computing. Basedon the argument that service provider needs only the monitoring and management functionalities instead of a direct ownership of them, we propose a new architecture, called NeuCloud, for trusted neutral cloud computing. The new architecture provides an unpriv-ileged service domain to the service provider and deprive the direct monitoring and management privilege of him. Instead, a neutral domain, as part of a mutual agreement between the client and the service provider, supports security monitoring and cloud management with minimum attack surface. As a result, privacy-preserving monitoring can be enabled in NeuCloud. In this paper, we introduce the NeuCloud design and describe how to implement NeuCloud in both Type-I and Type-II virtualization. Our experiments show that the overhead of NeuCloud is negligible.
Globally exponentially stable Kalman filtering for SLAM with AHRS

The Simultaneous Localization And Mapping (SLAM) estimation problem using range or bearing angle sensors is an inherently nonlinear problem due to the nonlinear relationship between the measurements and the positions of the landmarks and the pose of the vehicle. Assuming an Attitude and Heading Reference System (AHRS) and that velocity is measured, it is shown that the nonlinear kinematic models in the inertial coordinate frame and the nonlinear measurement models can be re-formulated globally as a linear time-varying system. This allows a globally exponentially stable Kalman filter to be used for real-time recursive estimation, under natural assumptions on the trajectory of the vehicle relative to the landmarks. This ensures theoretical guarantees of robustness of the estimate of the vehicle and landmark positions to inaccuracies and arbitrary estimator initialization. Simulations are used to illustrate the results.
A symbolic/subsymbolic interface protocol for cognitive modeling

Researchers studying complex cognition have grown increasingly interested in mapping symbolic cognitive architectures onto subsymbolic brain models. Such a mapping seems essential for understanding cognition under all but the most extreme viewpoints (namely, that cognition consists exclusively of digitally implemented rules; or instead, involves no rules whatsoever). Making this mapping reduces to specifying an interface between symbolic and subsymbolic descriptions of brain activity. To that end, we propose parameterization techniques for building cognitive models as programmable, structured, recurrent neural networks. Feedback strength in these models determines whether their components implement classically subsymbolic neural network functions (e.g., pattern recognition), or instead, logical rules and digital memory. These techniques support the implementation of limited production systems. Though inherently sequential and symbolic, these neural production systems can exploit principles of parallel, analog processing from decision-making models in psychology and neuroscience to explain the effects of brain damage on problem solving behavior.
Efficient recombinase-mediated cassette exchange at the AAVS1 locus in human embryonic stem cells using baculoviral vectors

Insertion of a transgene into a defined genomic locus in human embryonic stem cells (hESCs) is crucial in preventing random integration-induced insertional mutagenesis, and can possibly enable persistent transgene expression during hESC expansion and in their differentiated progenies. Here, we employed homologous recombination in hESCs to introduce heterospecific loxP sites into the AAVS1 locus, a site with an open chromatin structure that allows averting transgene silencing phenomena. We then performed Cre recombinase mediated cassette exchange using baculoviral vectors to insert a transgene into the modified AAVS1 locus. Targeting efficiency in the master hESC line with the loxP-docking sites was up to 100%. Expression of the inserted transgene lasted for at least 20 passages during hESC expansion and was retained in differentiated cells derived from the genetically modified hESCs. Thus, this study demonstrates the feasibility of genetic manipulation at the AAVS1 locus with homologous recombination and using viral transduction in hESCs to facilitate recombinase-mediated cassette exchange. The method developed will be useful for repeated gene targeting at a defined locus of the hESC genome.
Self-rated health and mortality in the high-functioning elderly--a closer look at healthy individuals: MacArthur field study of successful aging.

BACKGROUND This study tested the predictive value of self-rated health on 3-year mortality, with attention focused on healthy, high-functioning elders. METHODS Data from the MacArthur Field Study of Successful Aging were utilized. Subjects were 70-79-year-old (at baseline) residents of the communities of East Boston, MA, New Haven, CT, and a five-county area in and around Durham County, NC (N = 1192) which comprise three sites of the Established Populations for Epidemiologic Studies of the Elderly (EPESE). In-home interviews were conducted in 1988 and 1991. Logistic regression was performed to create odds ratios adjusted for age, sex, race, marital status, education, alcohol consumption, cigarette smoking, chronic diseases, past hospitalizations, and cognitive function. The sample was then divided into healthy and less healthy cohorts based on number of chronic diseases, and the analyses were repeated. RESULTS The adjusted odds ratios for self-rated health (poor/bad ratings compared to excellent ratings) in relation to mortality were 19.56 in the general sample, 93.51 in the healthy cohort, and 2.75 in the less healthy cohort. CONCLUSION Self-rated health is predictive of mortality in controlled analyses, with the greatest impact seen in healthy individuals. Health care professionals should be sensitive to the significance of poor self-rated health in apparently healthy patients.
Le Questionnaire sur l'Inquiétude et l'Anxiété. Validation dans des échantillons non cliniques et cliniques.

Bien que le trouble d'anxiete generalisee (TAG) soit l'un des troubles anxieux les plus frequents, les professionnels de la sante n'arrivent pas a bien le deceler chez leur clientele. Afin d'aider ceux-ci, il existe un instrument autoadministre qui permet d'evaluer les criteres diagnostiques du TAG : le Questionnaire sur l'inquietude et l'anxiete (QIA). Cette recherche comprend trois etudes qui ont mesure les qualites psychometriques du QIA. Les resultats de l'etude 1 indiquent que le QIA determine le degre d'inquietude de maniere specifique et sensible dans un echantillon non clinique. Pour ce qui est de l'etude 2, elle revele que le QIA distingue les patients atteints du TAG des sujets non cliniques. Enfin, les resultats de l'etude 3 demontrent que le QIA obtient un indice de fidelite test-retest satisfaisant dans un echantillon non clinique. Nous sommes donc en mesure d'affirmer que le QIA presente de bonnes qualites psychometriques dans des echantillons non cliniques et cliniques. Puisque le QIA se remplit en quelques minutes, il constitue un precieux outil diagnostique pour les professionnels de la sante.