Miracle-dz/UniFAR-FTUs huggingface dataset:
Response of symptom dimensions in obsessive-compulsive disorder to treatment with citalopram or placebo.

OBJECTIVE There is increasing evidence that the symptoms of obsessive-compulsive disorder lie on discrete dimensions. Relatively little work has, however, explored the relationship between such factors and response to pharmacotherapy. METHOD Data from a multi-site randomized placebo-controlled study of citalopram in obsessive-compulsive disorder were analyzed. Factor analysis of individual items and symptom categories of the Yale-Brown Obsessive-Compulsive Scale Checklist were undertaken, and the impact of symptom dimensions on treatment outcomes was analysed. RESULTS Factor analysis of Yale-Brown Obsessive-Compulsive Scale Checklist individual items yielded 5 factors (contamination/cleaning, harm/checking, aggressive/sexual/religious, hoarding/symmetry, and somatic/hypochondriacal). Hoarding/symmetry was associated with male gender, longer duration of obsessive-compulsive disorder and early onset, whereas contamination/cleaning was associated with female gender. Citalopram was more effective than placebo, but high scores on the symmetry/hoarding and contamination/cleaning subscales predicted worse outcome at the end of study while high scores on the aggressive/religious/sexual subscale predicted better outcome. Factor analysis of Yale-Brown Obsessive-Compulsive Scale Checklist symptom clusters yielded a 4 factor solution, but confirmed that symmetry/ordering was associated with male gender, early onset, and long duration of obsessive-compulsive disorder while high scores on the hoarding subscale predicted worse response to pharmacotherapy. CONCLUSION Citalopram shows good efficacy across the range of obsessive-compulsive disorder symptom dimensions. The relatively worse response of symmetry/hoarding to a selective serotonin reuptake inhibitor is consistent with other evidence that this symptom dimension is mediated by the dopamine system. There may be associations between symmetry/hoarding, male gender, early onset, tics, and particular genetic variants; further work is, however, needed to delineate fully obsessive-compulsive disorder subtypes and their underlying neurobiology.
A novel corpus-based stemming algorithm using co-occurrence statistics

We present a stemming algorithm for text retrieval. The algorithm uses the statistics collected on the basis of certain corpus analysis based on the co-occurrence between two word variants. We use a very simple co-occurrence measure that reflects how often a pair of word variants occurs in a document as well as in the whole corpus. A graph is formed where the word variants are the nodes and two word variants form an edge if they co-occur. On the basis of the co-occurrence measure, a certain edge strength is defined for each of the edges. Finally, on the basis of the edge strengths, we propose a partition algorithm that groups the word variants based on their strongest neighbors, that is, the neighbors with largest strengths. Our stemming algorithm has two static parameters and does not use any other information except the co-occurrence statistics from the corpus. The experiments on TREC, CLEF and FIRE data consisting of four European and two Asian languages show a significant improvement over no-stem strategy on all the languages. Also, the proposed algorithm significantly outperforms a number of strong stemmers including the rule-based ones on a number of languages. For highly inflectional languages, a relative improvement of about 50% is obtained compared to un-normalized words and a relative improvement ranging from 5% to 16% is obtained compared to the rule based stemmer for the concerned language.
Influence of cultural contexts on the appreciation of different cultural ecosystem services based on social network analysis

Since the Millennium Ecosystem Assessment, ecosystem science domain has made tremendous progress in the study of ecosystem services, but debates on neglected cultural ecosystem services (CES) have persisted. A recent approach established by the Intergovernmental Panel for Biodiversity and Ecosystem Services (IPBES) identifies and advocates incorporation of the CES through the role of local knowledge across other ecosystem services. However, approaches and tools that enable engagement of CES are limited. In this study, we examine how cultural contexts influence the appreciation of different CES, by identifying the behavioural aspects and the indigenous knowledge that has evolved on the basis of Social Network Analysis (SNA). SNA measures the network of relations between people and groups developed traditionally for a long time and their relational values with natural resources and ecosystem services. Through a comprehensive literature review of scholarly research published in Scopus data base, this study explicitly illustrates the interrelationship between SNA and CES. Keywords associated with SNA and cultural ecosystem services including forests, fisheries and agriculture (farming) were used. It was found that various aspects of social network uphold relational values of cultural importance and enhance resilience in groups amidst the social changes and times as societies progress. For instance, in the case of homophily, actors who are attracted to one another chose to interact in their defined network (e.g. fishing network) forming a strong social capital. Consequently, they shared similar beliefs and values that were eventually handed to the next generation of the network which shaped their heritage and identity. Social learning networks in various communities were also found to play a key role in information exchange and knowledge sharing among members compared to information from foreign technical experts. To fully integrate CES into sustainable decision making, this review suggests incorporation of the analysis of social networks formed in different cultural contexts globally.
System-Level Early Power Estimation for Memory Subsystem in Embedded Systems

Early power estimation is important to guide architectural design, especially for embedded systems. Since the power consumption of memory subsystem dominates, while DRAM and NAND Flash are the two main storage mediums nowadays, we analyze the power model of DRAM and propose a power model for NAND Flash, considering its system-level behaviors. Experimental results show that the accuracy of model proposed can be up to 95% .
The EGFR/ErbB3 Pathway Acts as a Compensatory Survival Mechanism upon c-Met Inhibition in Human c-Met+ Hepatocellular Carcinoma

Background c-Met, a high-affinity receptor for Hepatocyte Growth Factor (HGF), plays a critical role in tumor growth, invasion, and metastasis. Hepatocellular carcinoma (HCC) patients with activated HGF/c-Met signaling have a significantly worse prognosis. Targeted therapies using c-Met tyrosine kinase inhibitors are currently in clinical trials for HCC, although receptor tyrosine kinase inhibition in other cancers has demonstrated early success. Unfortunately, therapeutic effect is frequently not durable due to acquired resistance. Methods We utilized the human MHCC97-H c-Met positive (c-Met+) HCC cell line to explore the compensatory survival mechanisms that are acquired after c-Met inhibition. MHCC97-H cells with stable c-Met knockdown (MHCC97-H c-Met KD cells) were generated using a c-Met shRNA vector with puromycin selection and stably transfected scrambled shRNA as a control. Gene expression profiling was conducted, and protein expression was analyzed to characterize MHCC97-H cells after blockade of the c-Met oncogene. A high-throughput siRNA screen was performed to find putative compensatory survival proteins, which could drive HCC growth in the absence of c-Met. Findings from this screen were validated through subsequent analyses. Results We have previously demonstrated that treatment of MHCC97-H cells with a c-Met inhibitor, PHA665752, results in stasis of tumor growth in vivo. MHCC97-H c-Met KD cells demonstrate slower growth kinetics, similar to c-Met inhibitor treated tumors. Using gene expression profiling and siRNA screening against 873 kinases and phosphatases, we identified ErbB3 and TGF-α as compensatory survival factors that are upregulated after c-Met inhibition. Suppressing these factors in c-Met KD MHCC97-H cells suppresses tumor growth in vitro. In addition, we found that the PI3K/Akt signaling pathway serves as a negative feedback signal responsible for the ErbB3 upregulation after c-Met inhibition. Furthermore, in vitro studies demonstrate that combination therapy with PHA665752 and Gefitinib (an EGFR inhibitor) significantly reduced cell viability and increased apoptosis compared with either PHA665752 or Gefitinib treatment alone. Conclusion c-Met inhibition monotherapy is not sufficient to eliminate c-Met+ HCC tumor growth. Inhibition of both c-Met and EGFR oncogenic pathways provides superior suppression of HCC tumor growth. Thus, combination of c-Met and EGFR inhibition may represent a superior therapeutic regimen for c-Met+ HCC.
Male Nurse Practitioners' Views on Nursing Education as a Career Option: An Inductive Qualitative Content Analysis

ii ACKNOWLEDGMENTS . iii DEDICATION . iv LIST OF TABLES . viii LIST OF ABBREVIATIONS . ix CHAPTER I –INTRODUCTION . 10 Problem Statement . 11 Purpose . 12 Operational Definitions . 13 Assumptions, Limitations, Scope, and Delimitations . 13 Significance of the Study . 14 Transition Statement . 15 Summary . 16 CHAPTER II – REVIEW OF THE LITERATURE. 17 Introduction . 17 Current Nursing Shortage and Potential Solutions . 18 Males in Nursing Programs . 21 Vocational Choices for Males in Nursing . 25 Summary . 28 vi CHAPTER III METHOD . 29 Introduction . 29 Research Design and Approach . 29 Trustworthiness . 30 Role of the Researcher . 31 Instrument Development . 33 Procedures for Participant Selection . 34 Measures for Ethical Protection of the Participants . 34 Criteria for Selecting Participants . 35 Data Collection . 36 Data Analysis . 36 Summary . 38 CHAPTER IV – PRESENTATION AND ANALYSIS OF DATA . 39 Evidence of Quality . 40 Findings. 40 Description of the Findings by Interview Question . 46 Question 1 . 46 Question 2 . 47 Question 4 . 48 Question 5 . 49 vii Question 6 . 50 Question 7 . 51 Question 8 . 51 Question 9 . 52 Summary . 52 CHAPTER V – DISCUSSION, CONCLUSIONS, AND . 56 Recommendations . 56 Interpretation of Findings . 57 Implications for Social Change . 59 Recommendations for Action . 61 Reflections . 63 Conclusion . 63 APPENDIX A – Interview Questions . 66 APPENDIX B Inductive Content Analysis . 67 APPENDIX C – Permission Letter . 68 APPENDIX D – Oral Presentation . 74 APPENDIX E Consent Form . 75 APPENDIX F Demographic Questionnaire . 76 APPENDIX G – IRB Approval Letter . 77 REFERENCES . 78
Sensitivity of transitions in internal rotor molecules to a possible variation of the proton-to-electron mass ratio

Author Institution: Institute for Lasers, Life and Biophotonics, VU University Amsterdam, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands; Laboratoire Interuniversitaire des Systemes Atmospheriques, CNRS et Universites Paris Diderot et; Paris Est, 61 av. General de Gaulle, 94010; Creteil, France; Department of Physics and Centre for Laser, Atomic and Molecular Sciences, University of New Brunswick, Saint John, New Brunswick E2L 4L5, Canada
Forthcoming : Journal of Political Economy , February 2004 Capital Structure and Stock Returns ∗

U.S. corporations do not issue and repurchase debt and equity to counteract the mechanistic effects of stock returns on their debt equity ratios. Thus, over 1–5 year horizons, stock returns can explain about 40% of debt ratio dynamics. Although corporate net issuing activity is lively, and although it can explain 60% of debt ratio dynamics (long-term debt issuing activity being most capital structure relevant), corporate issuing motives remain largely a mystery. When stock returns are accounted for, many other proxies used in the literature, play a much lesser role in explaining capital structure.
Following Live Kidney Donation Perioperative Mortality and Long-term Survival

Supplementary material http://jama.ama-assn.org/cgi/content/full/303/10/959/DC1 eSupplement Correction Contact me if this article is corrected. Citations Contact me when this article is cited. This article has been cited 1 time. Topic collections Contact me when new articles are published in these topic areas. Other; Prognosis/ Outcomes Endocrine Surgery; Transplantation; Kidney Transplantation; Transplantation, Quality of Care; Patient Safety/ Medical Error; Surgery; Surgical Interventions;
Validity of Quantitative Lymphoscintigraphy as a Lymphedema Assessment Tool for Patients With Breast Cancer

Objective To evaluate the validity of quantitative lymphoscintigraphy as a useful lymphedema assessment tool for patients with breast cancer surgery including axillary lymph node dissection (ALND). Methods We recruited 72 patients with lymphedema after breast cancer surgery that included ALND. Circumferences in their upper limbs were measured in five areas: 15 cm proximal to the lateral epicondyle (LE), the elbow, 10 cm distal to the LE, the wrist, and the metacarpophalangeal joint. Then, maximal circumference difference (MCD) was calculated by subtracting the unaffected side from the affected side. Quantitative asymmetry indices (QAI) were defined as the radiopharmaceutical uptake ratios of the affected side to the unaffected side. Patients were divided into 3 groups by qualitative lymphoscintigraphic patterns: normal, decreased function, and obstruction. Results The MCD was highest in the qualitative obstruction (2.76±2.48) pattern with significant differences from the normal (0.69±0.78) and decreased function (1.65±1.17) patterns. The QAIs of the axillary LNs showed significant differences among the normal (0.82±0.29), decreased function (0.42±0.41), and obstruction (0.18±0.16) patterns. As the QAI of the axillary LN increased, the MCD decreased. The QAIs of the upper limbs were significantly higher in the obstruction (3.12±3.07) pattern compared with the normal (1.15±0.10) and decreased function (0.79±0.30) patterns. Conclusion Quantitative lymphoscintigraphic analysis is well correlated with both commonly used qualitative lymphoscintigraphic analysis and circumference differences in the upper limbs of patients with breast cancer surgery with ALND. Quantitative lymphoscintigraphy may be a good alternative assessment tool for diagnosing lymphedema after breast cancer surgery with ALND.
DIRECT DEGREE ELEVATION OF NURBS CURVES

In this paper we provide the guidelines for the direct degree elevation of NURBS curves. Through the analysis of linear equation systems of quartic and lower degree splines we derive a direct relation between the knot vector of a spline and the degree elevation coefficients. We also present a direct degree elevation scheme and several algorithms based on the discovered relation. Experimental results indicate that the direct degree elevation algorithms are up to twice more time-efficient than Piegl and Tiller’s degree elevation method. This proves the inefficiency of Bspline calculation schemes based on blossoming that involve redundant operations with control points. It also negates Piegl and Tiller’s claim about the inefficiency of linear equation system solving method for quartic and lower degrees.
STRUCTURAL DAMAGE ASSESSMENT USING THE ANT COLONY OPTIMIZATION TECHNIQUE

Structural systems in a variety of applications including aerospace vehicles, automobiles and engineering structures such as tall buildings, bridges and offshore platforms, accumulate damage during their service life. In several situations, such damage may not be visually observable. From the standpoint of both safety and performance, it is desirable to monitor the occurrence, location and extent of such damage. System identification methods, which may be classified in a general category of nondestructive evaluation techniques, can be employed for this purpose. Using experimental data, such as eigenmodes and static displacements, and an analytical structural model, parameters of the structures can be identified. The approach used in the present work is one where the structural properties of the analytical model are varied to minimize the difference between the analytically predicted and empirically measured response. This is an inverse problem where the structural parameters are identified. In this work a reduced number of static displacements and vibration modes were used as the measured response. For the damage assessment problem a close analytical model of the structural system is available and the model of the damaged structure will be identified. Damage will be represented by a reduction in the elastic stiffness properties of the structure. The problem described above was solved using global methods of optimization due to the fact that depending on the number of variables or the location of damage the resulting design space is nonconvex presenting several local minima. In the present work, the ant colony optimization (ACO) was used. It is a metaheuristic inspired by the ant’s behavior developed initially for combinatorial optimization and extended for continuous domains. The approach was applied to simple truss structures with different levels of damage and presented promising results.
Constrained feature selection for localizing faults

Developers often take much time and effort to find buggy program elements. To help developers debug, many past studies have proposed spectrum-based fault localization techniques. These techniques compare and contrast correct and faulty execution traces and highlight suspicious program elements. In this work, we propose constrained feature selection algorithms that we use to localize faults. Feature selection algorithms are commonly used to identify important features that are helpful for a classification task. By mapping an execution trace to a classification instance and a program element to a feature, we can transform fault localization to the feature selection problem. Unfortunately, existing feature selection algorithms do not perform too well, and we extend its performance by adding a constraint to the feature selection formulation based on a specific characteristic of the fault localization problem. We have performed experiments on a popular benchmark containing 154 faulty versions from 8 programs and demonstrate that several variants of our approach can outperform many fault localization techniques proposed in the literature. Using Wilcoxon rank-sum test and Cliff's d effect size, we also show that the improvements are both statistically significant and substantial.
Generalized Weinberg sum rules in deconstructed QCD

Recently, Son and Stephanov have considered an ``open moose'' as a possible dual model of a QCD-like theory of chiral symmetry breaking. In this note we demonstrate that although the Weinberg sum rules are satisfied in any such model, the relevant sums converge very slowly and in a manner unlike QCD. Further, we show that such a model satisfies a set of generalized sum rules. These sum rules can be understood by looking at the operator product expansion for the correlation function of chiral currents, and correspond to the absence of low-dimension gauge-invariant chiral symmetry breaking condensates. These results imply that, regardless of the couplings and F-constants chosen, the open moose is not the dual of any QCD-like theory of chiral symmetry breaking. We also show that the generalized sum rules can be ``solved'', leading to a compact expression for the difference of vector- and axial-current correlation functions. This expression allows for a simple formula for the S parameter (L10), which implies that S is always positive and of order one in any (unitary) open linear moose model. Therefore the S parameter is positive and order one in any ``Higgsless model'' based on the continuum limit of a linear moose regardless of the warping or position-dependent gauge-coupling chosen.
A high assurance virtualization platform for ARMv8

This paper presents the first results from the ongoing research project HASPOC, developing a high assurance virtualization platform for the ARMv8 CPU architecture. Formal verification at machine code level guarantees information isolation between different guest systems (e.g. OSs) running on the platform. To use the platform in networking scenarios, we allow guest systems to securely communicate with each other via platform-provided communication channels and to take exclusive control of peripherals for communication with the outside world. The isolation is shown to be formally equivalent to that of guests executing on physically separate platforms with dedicated communication channels crossing the air-gap. Common Criteria (CC) assurance methodology is applied by preparing the CC documentation required for an EAL6 evaluation of products using the platform. Besides the hypervisor, a secure boot component is included and verified to ensure system integrity.
Cost-effectiveness of resuvastatin in comparison with generic atorvastatin and simvastatin in a Swedish population at high risk of cardiovascular events

Sanya K. Gandhi, Marie M. Jensen, Kathleen M. Fox, Lee Smolen, Anders Olsson and Thomas Paulsson, Cost-effectiveness of resuvastatin in comparison with generic atorvastatin and simvastatin in a Swedish population at high risk of cardiovascular events, 2012, ClinicoEconomics and Outcomes Research, (4), 1-11. http://dx.doi. org/10.2147/CEOR.S26621 Copyright: Dove Medical Press http://www.dovepress. com/
Emerging Paradigms in Genomics-Based Crop Improvement

Next generation sequencing platforms and high-throughput genotyping assays have remarkably expedited the pace of development of genomic tools and resources for several crops. Complementing the technological developments, conceptual shifts have also been witnessed in designing experimental populations. Availability of second generation mapping populations encompassing multiple alleles, multiple traits, and extensive recombination events is radically changing the phenomenon of classical QTL mapping. Additionally, the rising molecular breeding approaches like marker assisted recurrent selection (MARS) that are able to harness several QTLs are of particular importance in obtaining a “designed” genotype carrying the most desirable combinations of favourable alleles. Furthermore, rapid generation of genome-wide marker data coupled with easy access to precise and accurate phenotypic screens enable large-scale exploitation of LD not only to discover novel QTLs via whole genome association scans but also to practise genomic estimated breeding value (GEBV)-based selection of genotypes. Given refinements being experienced in analytical methods and software tools, the multiparent populations will be the resource of choice to undertake genome wide association studies (GWAS), multiparent MARS, and genomic selection (GS). With this, it is envisioned that these high-throughput and high-power molecular breeding methods would greatly assist in exploiting the enormous potential underlying breeding by design approach to facilitate accelerated crop improvement.
Multiple omnidirectional sound source tracking using sequential updating histogram

In this paper, a method for omnidirectional sound source tracking using a circular microphone array is proposed. The sequential updating histogram estimated every two microphones are integrated for the sound source tracking. The histogram is estimated by weighting those reliability to results obtained every adjacent microphone pair. In addition, the wrapped Cauchy mixture distribution is used to detect the omnidirectional DOA and the number of sound sources. As a result, the accurate omnidirectional sound source tracking can be achieved. Several experimental results are shown to present the effectiveness of the proposed method.