Miracle-dz/UniFAR-FTUs huggingface dataset:
Antimicrobial activity of wet chemically engineered spherical shaped ZnO nanoparticles on food borne pathogen.

Nanotechnology is being envisioned as a hurriedly developing field, it has potential to revolutionize food systems and improve the conditions of the food quality. The present study reports the synthesis of ZnO nanoparticles using wet chemical method and used as antimicrobial agent against Food borne Pathogens. The antibacterial activity of ZnO nanoparticles was examined against E. coli, and Pseudomonas aueroginosa, the maximum inhibition was occurred at 100 μl. The concentration of ZnO in 100 μl is 100 μg. The antifungal activity of ZnO nanoparticles was also analyzed against Aspergillus niger and the maximum inhibition was found at 400 μl. This wet chemical mediated synthesis of ZnO nanoparticles is a rapid and it could not produce any toxic chemical along with the nanoparticles. Moreover, the antimicrobial effect of ZnO nanoparticles against food borne pathogen may leads to the proficient application in food packaging and preservation process.
Design and Implementation of a Database Programming Language for XML-based Applications

XML is the de facto standard for data exchange between arbitrary applications. These applications are written in object-oriented programming languages like Java or C# for example. Consequently the need arises to integrate XML into existing object-oriented programming languages. Moreover, many applications have to keep and deal with persistent data and objects. A lot of frameworks are currently being developed which are trying to solve mismatch problems between the transient object model and the persistent data model. Due to performance reasons relational databases are taken in general. Although existing approaches try to minimize the mapping effort, true transparent persistency is not gained at the moment. In this work transparent persistency means that objects can be stored regardless of type, algorithms remain unchanged whether they operate on persistent or transient data and finally that programmers, if at all, deal with persistency on a very high level. In addition many persistence solutions do not even support the main object-oriented concepts like inheritance and polymorphism. As well object-oriented databases are limited to a single programming language and are rarely available. All that the frameworks or approaches mentioned so far have got in common is that the programmer has to add special code when dealing with persistent objects or classes. The code includes communication with a so-called persistency manager for example. In the past several database programming languages have been developed, but they all have tried to integrate the relational model. Consequently, a holistic and transparent solution is needed that integrates XML and persistency into an existing object-oriented programming language. In this work XOBEDBPL (XML OBjEts DataBase Programming Language) is developed as an extension of the object-oriented programming language Java. XOBEDBPL is based on its predecessor project XOBE. In XOBE XML and XPath are already integrated and checked statically at compile time against an XML schema. XML Schemas and DTDs are supported as XML schema description languages. In XOBEDBPL XML objects can now be manipulated with the help of updates. Moreover the type checking process of XOBE is extended to support updates and more complex queries as well. Additionally, transparent type independent persistency supporting all object-oriented concepts is introduced in XOBEDBPL for the first time. The prototypical implementation is based on a persistency layer using web services. The persistency layer keeps persistent objects and data and offers the possibility to exchange data among arbitrary languages and applications. Moreover, it is shown that the introduced concepts can also be realized as a semantical extension of Java. Consequently programmers do not have to learn
Anatomy and function of the anal longitudinal muscle

Sir The recent paper by Mr Anderson and colleagues ( R r J Surg 1992; 79: 1080-1) is clearly a step in the right direction to minimize an otherwise major surgical intervention. There is no doubt, however, that a great deal of skill and care is required to ensure that the correct loop of bowel is withdrawn. I am aware of one such operation where the sigmoid colon was transected and the distal loop brought to the surface by mistake. with catastrophic results. In two patients 1 have used a laparoscopic technique to create a colostomy, both for palliation. The advantages are clear in that a thorough inspection of the abdominal contents is usually possible, the loop to be brought up is readily identified and can be dissected free, and the surgical insult to the patient is minimal. The initial pneumoperitoneum and laparoscopy is performed using the Hasson technique of open laparoscopy'. particularly if there has been previous surgery or in the presence of obstruction. Before operation two stoma points are marked: one convenient for sigmoid colon and one for transverse colon. One or other of these sites is used to insert a second trocar. A third cannula is inserted in the right side of the abdomen at a convenient site, and this should be 12 mm to allow the passage of an Endo-CIA (Auto Suture. Ascot. U K ) stapler. In both cases it was possible to mobilize the sigmoid colon, pass a vascular sling, and wilhdraw it up to the colostomy cannula. I t is important to remember that i n the insufflated (and therefore distended ) abdo'men the colon may not reach as easily to the surface, and one should make a trial of deflating the abdomen to ensure adequate but not excessive mobilization. In the first patient. whose pelvis was obstructed by a massive carcinoma of the prostate, i t was possible to extend the incision around the cannula and pull up the loop. An oxalbumin buffer (Biethium; Ethicon. Edinburgh, U K ) was inserted as a bridge, which was sutured in place using 0 Vicryl (Ethicon), and then the colostomy was opened and sutured to the skin as usual using 2. 0 catgut. This procedure created a definitive loop stoma without the need for glass rods o r plastic bridges. In the second patient, with irresectable rectal carcinoma, the Endo-CIA stapler was used to transect the distal sigmoid, requiring two passes of the instrument to ensure a good seal (the advent of the new 60-mm staplers will make this far easier). It was then possible to place further vascular staples across the mesentery to separate the bowel ends adequately. The proximal end was brought out as an end colostomy and sutured to the skin with catgut after widening the left iliac fossa port. N o complications occurred with either patient, both ofwhom are alive 6 months later after radiotherapy and chemotherapy.
Extending open compilers

Domain-specic language implementation is in general not an easy task. This is the main reason that kept them from getting more attention and reaching the expectations of domain-specic language researchers. Implementation of a domain-specic language can be demanding, but also very rewarding. Once the hard work is done, we can prot a lot from the effort invested. The purpose of this paper is to present a domain specic language construction with extending the open compilers. Their source code n available, well organized and clear n gives the language designers a possibility to incorporate their domain specic constructs into the general-purpose language by extending its compiler. In this paper, we present extension of Mono C# compiler with representative domain-specic language.
UH Cancer Center Hotline: the training and education program of the University of Guam/University of Hawai'i Cancer Center Partnership.

Although funding from United States and international health organizations is contributing to infrastructure development and health systems strengthening in the Pacific region, Guam and the neighboring US-Affiliated Pacific Islands (USAPI) have historically lacked the infrastructure (eg, cancer screening and treatment facilities, scientific laboratories, long-standing cancer registries) and trained personnel (eg, researchers, clinicians, data registrars) necessary to conduct effective cancer research. Weaknesses in the regional educational pipeline (K-12), particularly in mathematics and science, contribute to the low numbers of Americans of Pacific Island ancestry in master's and doctoral degree programs across the country.1 Relatively low faculty salaries, geographical isolation, limited funding, outdated facilities, institutional barriers, and outmigration further challenge efforts led by academic and leading research institutions to establish research training programs and research partnerships in the region. Despite the many challenges, however, it is clear that research and research training must be part of the solution if the Pacific region and Pacific Islanders are to realize improved health, less suffering, and fewer deaths in the 21st century. The University of Hawai‘i Cancer Center (UHCC) and the University of Guam (UOG) have shared a commitment to serve the needs of populations and communities in the Pacific region through improving cancer research, care, training and education, and outreach to ultimately reduce cancer health disparities in the region. Funding from the National Cancer Institute's (NCI) Center to Reduce Cancer Health Disparities supports the long-standing partnership of the two institutions, initiated in 2002 to increase the number of minority scientists of Pacific Islander ancestry engaged in cancer research while building capacity at the University of Guam to conduct cancer research, and to sharpen the focus at UHCC in addressing cancer health disparities relevant to the Pacific region. Towards this objective, the UOG/UHCC Partnership supports a Training and Education Program. The aims of the Training and Education Program include: Train minority Pacific Islander students in cancer research at the MS level at the University of Guam and at the PhD level at the University of Hawai‘i; Stimulate cancer research efforts at the University of Guam through mentorship and faculty development; and Develop a cancer health disparities track in the Micronesian Studies Program, a master's program at the University of Guam.
Peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3‐II

Pexophagy can be experimentally induced in mammalian cells by removing the culture serum. Pex14p, a peroxisomal membrane protein essential for matrix protein import in docking of soluble receptor Pex5p, is involved in the mammalian autophagic degradation of peroxisomes and interacts with the lipidated form of LC3, termed LC3‐II, an essential factor for autophagosome formation, under the starvation condition in CHO‐K1 cells. However, molecular mechanisms underlying the Pex14p‐LC3‐II interaction remain largely unknown. To verify whether Pex14p directly binds LC3‐II, we reconstituted an in vitro conjugation system for synthesis of LC3‐II. We show here that Pex14p directly interacts with LC3‐II via the transmembrane domain of Pex14p. Pex5p competitively inhibited this interaction, implying that Pex14p preferentially binds to Pex5p under the nutrient‐rich condition. Moreover, a Pex5p mutant defective in PTS1‐protein import lost its affinity for Pex14p under the condition of nutrient deprivation, thereby more likely explaining why Pex14p prefers to interact with LC3‐II under the starvation condition in vivo. Together, these results suggest that Pex14p is a unique factor that functions in the dual processes in peroxisomal biogenesis and degradation with the coordination of Pex5p in response to the environmental changes.
IT Enabled Organisational Agility: Evidence from Chinese Firms

This paper examines the role of information technology IT in enabling organisational agility. The authors focus on two IT capabilities, IT exploration and IT exploitation. On the basis of conceptualisation of the capability lifecycle and a hierarchy of dynamic capabilities, the authors establish a theoretical linkage between lower-order capability and higher-order capability, i.e., IT exploration capability to IT exploitation capability to organisational agility. Using the partial least square approach, the authors empirically test the proposed relationships using data from 289 manufacturers in the Pearl River Delta region of Guangdong province, People's Republic of China. Our results suggest the positive effects of IT exploration and exploitation capabilities on customer, operational and partner agilities. In addition, the authors find that IT exploitation capability mediates the relationship between IT exploration capability and organisational agility. On the basis of our findings, implications for theory and practice as well as future research opportunities are discussed.
Generation of a Stable Transgenic Swine Model Expressing a Porcine Histone 2B-eGFP Fusion Protein for Cell Tracking and Chromosome Dynamics Studies

Transgenic pigs have become an attractive research model in the field of translational research, regenerative medicine, and stem cell therapy due to their anatomic, genetic and physiological similarities with humans. The development of fluorescent proteins as molecular tags has allowed investigators to track cell migration and engraftment levels after transplantation. Here we describe the development of two transgenic pig models via SCNT expressing a fusion protein composed of eGFP and porcine Histone 2B (pH2B). This fusion protein is targeted to the nucleosomes resulting a nuclear/chromatin eGFP signal. The first model (I) was generated via random insertion of pH2B-eGFP driven by the CAG promoter (chicken beta actin promoter and rabbit Globin poly A; pCAG-pH2B-eGFP) and protected by human interferon-β matrix attachment regions (MARs). Despite the consistent, high, and ubiquitous expression of the fusion protein pH2B-eGFP in all tissues analyzed, two independently generated Model I transgenic lines developed neurodegenerative symptoms including Wallerian degeneration between 3–5 months of age, requiring euthanasia. A second transgenic model (II) was developed via CRISPR-Cas9 mediated homology-directed repair (HDR) of IRES-pH2B-eGFP into the endogenous β-actin (ACTB) locus. Model II transgenic animals showed ubiquitous expression of pH2B-eGFP on all tissues analyzed. Unlike the pCAG-pH2B-eGFP/MAR line, all Model II animals were healthy and multiple pregnancies have been established with progeny showing the expected Mendelian ratio for the transmission of the pH2B-eGFP. Expression of pH2B-eGFP was used to examine the timing of the maternal to zygotic transition after IVF, and to examine chromosome segregation of SCNT embryos. To our knowledge this is the first viable transgenic pig model with chromatin-associated eGFP allowing both cell tracking and the study of chromatin dynamics in a large animal model.
Data Sufficiency for Online Writer Identification: A Comparative Study of Writer-Style Space vs. Feature Space Models

A key factor in building effective writer identification/verification systems is the amount of data required to build the underlying models. In this research we systematically examine data sufficiency bounds for two broad approaches to online writer identification -- feature space models vs. writer-style space models. We report results from 40 experiments conducted on two publicly available datasets and also test identification performance for the target models using two different feature functions. Our findings show that the writer-style space model gives higher identification performance for a given level of data and further, achieves high performance levels with lesser data costs. This model appears to require as less as 20 words per page to achieve identification performance close to 80% and reaches more than 90% accuracy with higher levels of data enrollment.
Neural network-based model predictive control for wastegate of a turbocharged gasoline engine

In this paper, a model predictive control strategy based on neural network is developed for the boost pressure tracking of a turbocharged gasoline engine. Firstly, the predictive model is trained by neural network due to its capacity of learning nonlinear process, institutive structure and simple training procedure. Secondly, the online linearization of neural network model is deduced by Taylor's expansion, and the feasibility of neural network model and linear predictive model are accessed. Thirdly, with the requirements of boost pressure tracking control, a linear model predictive controller is designed to track the desired boost pressure by adjusting the wastegate. Finally, the simulation results show the effectiveness of the proposed controller.
Pedigree disequilibrium tests for multilocus haplotypes

Association tests of multilocus haplotypes are of interest both in linkage disequilibrium mapping and in candidate gene studies. For case‐parent trios, I discuss the extension of existing multilocus methods to include ambiguous haplotypes in tests of models which distinguish between the cis and trans phase. A likelihood‐ratio test is proposed, using the expectation‐maximization (E‐M) algorithm to account for haplotype ambiguities. Assumptions about the population structure are required, but realistic situations, including population stratification, which violate the assumptions lead to conservative tests. I describe a permutation procedure for the null hypothesis of interest, which controls for violation of the assumptions. For general pedigrees, I describe extensions of the pedigree disequilibrium test to include uncertain haplotypes. The summary statistics are replaced by their expected values over prior distributions of haplotype frequencies. If prior distributions are not available, a valid test is possible by using the E‐M algorithm to estimate the null distribution of haplotype frequencies. Similar methods are available for quantitative traits. Exact permutation tests are difficult to construct in small samples, but an approximate procedure is appropriate in large samples, and can be used to account for dependencies between tests of multiple haplotypes and loci. Genet Epidemiol 25:115–121, 2003. © 2003 Wiley‐Liss, Inc.
An expanded definition of the adult respiratory distress syndrome.

More than twenty years ago, Ashbaugh and coworkers, (1), in a now classic article, described. 12 patients whose striking but uniform clinical, physiologic, roentgenographic,and pathologic abnormalities distinguished them from among 272adult patients who had received respiratory support in the intensive care units of Colorado General Hospital and Denver General Hospital. The 12patients all had severedyspnea, tachypnea, cyanosis that was refractory to oxygen therapy, decreased respiratory system compliance, and diffuse alveolar infiltrations on their chest radiographs. Pathologic examination in seven patients who died revealed atelectasis, vascular congestion and hemorrhage, severe pulmonary edema and hyaline membranes. Shortly afterward, Petty and coworkers (2), called this constellation of findings the adult respiratory distress syndrome (ARDS). Since then, ARDS has been recognized as an entity throughout the world and has been the subject of numerous conferences, hundreds of articles, and several books. As a result of this activity, much descriptive information has been obtained about ARDS, and we have learned a lot about its clinical features, physiologic disturbances, prognosis, and pathologic findings. And yet formidable problems remain: there is disagreement about exactly what ARDS is and on what causes it; more importantly, available empiric treatment is inadequate, and mortality remains unacceptably high (600/0 or more) (3). This appears to be one of the few points of agreement among investigators, but even that statement is arguable (4). We believe that much of the controversy concerning ARDS is explained by the lack of a satisfactory definition of this elusivesyndrome. How can you collect, much less compare, epidemiologicdata and mortality figures when there is no uniformly accepted (and used) definition? How can you study basic pathophysiologic mechanisms, understand natural history, and above all, evaluate new therapeutic approaches in what appears now to be an amalgam of many different disorders? The purpose of this article, therefore, is to propose an expanded definition of ARDS that takes into account new knowledge about
[Value of urethral ultrasound in evaluation of pathologic urethral changes].

AIM To compare the evaluation of urethral stricture disease using ultrasonic urethrography and standard retrograde urethrography (RUG). METHOD 175 male patients suspected of having urethral stricture disease underwent urethral sonography prior to RUG in a prospective, non-randomized study. RESULTS A correct positive diagnosis was established in 98% of the cases; a correct negative diagnosis in 96%. The sensitivity and specificity of urethral ultrasound in detecting urethral strictures were 98% and 96%, respectively. CONCLUSION Ultrasound offers a three-dimensional study to evaluate the urethral without exposing the gonads to ionizing radiation. The exact length and depth of a stricture, the severity of the strictured segment as well as the anatomy of the periurethral scars were diagnosed accurately. Urethral ultrasound is a simple, inexpensive and rapid investigation of the urethra which should be the preferred diagnostic procedure in the evaluation of strictures in the anterior urethra of men.
Identifying root causes of inefficiencies in road haulage: case studies from Sweden, Switzerland and Germany

ABSTRACT Road haulage operations in general, and distribution in particular, are inefficient. Given the societal importance of road haulage and the low efficiency of the sector, road hauliers need to improve their operations and systematically tackle inefficiencies. However, the real causes of these inefficiencies, the ‘root causes’, have not been sufficiently examined in previous studies. This paper expands on prior research by adapting existing models that can be used to identify the root causes of inefficiencies, and to enable systematic improvements in road transport operations. Our research is based on a lean approach and an adapted version of Ishikawa’s model. It is shown as a matrix based on transport processes and the Ishikawa categories to identify the root causes of inefficiencies in road haulage that influence performance. The adapted model was tested in three road haulage case studies. Our findings suggest that most efficiency problems appear in the actual transport execution.
OBSERVING THE END OF COLD FLOW ACCRETION USING HALO ABSORPTION SYSTEMS

We use cosmological smoothed particle hydrodynamic simulations to study the cool, accreted gas in two Milky Way size galaxies through cosmic time to z = 0. We find that gas from mergers and cold flow accretion results in significant amounts of cool gas in galaxy halos. This cool circum-galactic component drops precipitously once the galaxies cross the critical mass to form stable shocks, Mvir = Msh ∼ 1012 M☉. Before reaching Msh, the galaxies experience cold mode accretion (T < 105 K) and show moderately high covering fractions in accreted gas: fc ∼ 30%–50% for R < 50 comoving kpc and 10^{16}$? > cm−2. These values are considerably lower than observed covering fractions, suggesting that outflowing gas (not included here) is important in simulating galaxies with realistic gaseous halos. Within ∼500 Myr of crossing the Msh threshold, each galaxy transitions to hot mode gas accretion, and fc drops to ∼5%. The sharp transition in covering fraction is primarily a function of halo mass, not redshift. This signature should be detectable in absorption system studies that target galaxies of varying host mass, and may provide a direct observational tracer of the transition from cold flow accretion to hot mode accretion in galaxies.