Miracle-dz/UniFAR-FTUs huggingface dataset:
A pattern-based approach to DSL development

Tool support for the development of Domain-specific Languages (DSLs) is continuously increasing. This reduces implementation effort for DSLs and enables the development of rather complex languages within reasonable amounts of time. However, the lack of commonly agreed and applied language engineering processes, many times turns DSL development into a set of creative activities, whose outcomes depend on the experience of the developers involved. Consequently, outcomes of language engineering activities are unpredictable with respect to their quality, and are often not maintainable either. We have therefore developed an approach that transfers the concept of architecture and design patterns from software engineering to language development. In this paper, we propose this approach and evaluate its applicability in a case study.
Frog2: Efficient 3D conformation ensemble generator for small compounds

Frog is a web tool dedicated to small compound 3D generation. Here we present the new version, Frog2, which allows the generation of conformation ensembles of small molecules starting from either 1D, 2D or 3D description of the compounds. From a compound description in one of the SMILES, SDF or mol2 formats, the server will return an ensemble of diverse conformers generated using a two stage Monte Carlo approach in the dihedral space. When starting from 1D or 2D description of compounds, Frog2 is capable to detect the sites of ambiguous stereoisomery, and thus to sample different stereoisomers. Frog2 also embeds new energy minimization and ring generation facilities that solve the problem of some missing cycle structures in the Frog1 ring library. Finally, the optimized generator of conformation ensembles in Frog2 results in a gain of computational time permitting Frog2 to be up to 20 times faster that Frog1, while producing satisfactory conformations in terms of structural quality and conformational diversity. The high speed and the good quality of generated conformational ensembles makes it possible the treatment of larger compound collections using Frog2. The server and documentation are freely available at http://bioserv.rpbs. univ-paris-diderot.fr/Frog2.
Steroid Injection for Reinke's Edema Using Fiberoptic Laryngeal Surgery

Objective Since 1990, we have performed steroid injections into the vocal fold under topical anesthesia using fiberoptic laryngeal surgery (FLS) in an outpatient clinic. The aim of this study was to retrospectively assess the usefulness of this treatment method in 44 patients with mild Reinke's edema. Material and Methods Using fiberoptic monitoring of the larynx, a curved injection needle was inserted via the oral cavity and triamcinolone acetonide was injected into Reinke's space of the bilateral vocal fold. Results Remission or improvement was observed in almost all patients in terms of both patients' self-rating of hoarseness and endoscopic vocal fold findings The maximum phonation time was a mean of 9.0 s before operation and 11.4 safter operation, and this increase was significant (p < 0.01). Voice pitch also improved, from 168 to 181 Hz, in female patients, and this increase was also significant (p < 0.05). Conclusion Steroid injection is considered to be useful for treating mild Reinke's edema.
The strategic value of sustainability and its disclosure : Three essays on the Impact of Sustainability Performance, Disclosure & Reputation on Firms’ Financial Performance

The signaling perspective argues that when a firm limits the extent of its sustainability disclosure, it prevents stakeholders from evaluating its achieved degree of sustainability performance, and may thus reach higher financial returns. However, transparency is an institutionalized norm that stakeholders value, and firms may not be able to limit their disclosure without being penalized. This thesis therefore raises the question of whether firms can strategically limit their sustainability disclosure to reach higher profits, or if pressure for conformity to the norm of transparency exists and weakens such strategies. Using econometrical methods, this thesis empirically shows that sustainability raters do not converge in their assessment of firms’ sustainability performance, supporting the assumption that firmsmay prevent stakeholders from evaluating their actual degree of sustainability. It also shows that less sustainable and more reputed firms are more likely to limit their sustainability disclosure, that highly sustainable firms encounter higher short and long term financial returns when they adopt an extensive disclosure, and that less sustainable firms, on the contrary are more profitable in the short term when theylimit their disclosure. This thesis therefore shows that in line with the signaling perspective, firms may strategically adjust the extent on their disclosure to reach higher returns in the short term. However, in the long term, normative pressure for transparency is too high and weakens the benefits of such strategies.
A user-based design process for Web sites

This paper reports on Phase II of a two‐part project to identify and implement user‐based design criteria in World Wide Web sites. The test site is a Web page for the academic business community. As an alternative to existing, largely ad hoc design processes, the authors developed a user‐based design process, gathering user input at three different times in the process. Delineating this four‐stage process (information‐gathering; development; test and evaluation; and implementation) is a major focus of the paper. In addition to explaining the process in detail, the paper reports on the second stage of this process, which involves operationalizing definitions of the criteria and translating the criteria into Web page features and, to some extent, on the evaluation activities undertaken during Stage 3. Already reported are the results of Stage 1, which gathered user criteria for evaluating Web sites through a focus group session.
Evaluation and Application of 600 V GaN HEMT in Cascode Structure

Gallium nitride high electron mobility transistor (GaN HEMT) has matured dramatically over the last few years. A progressively larger number of GaN devices have been manufactured for in field applications ranging from low power voltage regulators to high power infrastructure base-stations. Compared to the state-of-the-art silicon MOSFET, GaN HEMT has a much better figure of merit and shows potential for high-frequency applications. The first generation of 600 V GaN HEMT is intrinsically normally on device. To easily apply normally on GaN HEMT in circuit design, a low-voltage silicon MOSFET is in series to drive the GaN HEMT, which is well known as cascode structure. This paper studies the characteristics and operation principles of a 600 V cascode GaN HEMT. Evaluations of the cascode GaN HEMT performance based on buck converter at hard-switching and soft-switching conditions are presented in detail. Experimental results prove that the cascode GaN HEMT is superior to the silicon MOSFET, but it still needs soft-switching in high-frequency operation due to considerable package and layout parasitic inductors and capacitors. The cascode GaN HEMT is then applied to a 1 MHz 300 W 400 V/12 V LLC converter. A comparison of experimental results with a state-of-the-art silicon MOSFET is provided to validate the advantages of the GaN HEMT.
Disambiguation of morphological analysis in Bantu languages

The paper describes problems in disambiguating the morphological analysis of Bantu languages by using Swahili as a test language. The main factors of ambiguity in this language group can be traced to the noun class structure on one hand and to the bi-directional word-formation on the other. In analyzing word-forms, the system applied utilizes SWATWOL, a morphological parsing program based on two-level formalism. Disambiguation is carried out with the latest version (April 1996) of the Constraint Grammar Parser (CGP). Statistics on ambiguity are provided. Solutions for resolving different types of ambiguity are presented and they are demonstrated by examples from corpus text. Finally, statistics on the performance of the disambiguator are presented.
Transcriptome-Wide Survey and Expression Profile Analysis of Putative Chrysanthemum HD-Zip I and II Genes

The homeodomain-leucine zipper (HD-Zip) transcription factor family is a key transcription factor family and unique to the plant kingdom. It consists of a homeodomain and a leucine zipper that serve in combination as a dimerization motif. The family can be classified into four subfamilies, and these subfamilies participate in the development of hormones and mediation of hormone action and are involved in plant responses to environmental conditions. However, limited information on this gene family is available for the important chrysanthemum ornamental species (Chrysanthemum morifolium). Here, we characterized 17 chrysanthemum HD-Zip genes based on transcriptome sequences. Phylogenetic analyses revealed that 17 CmHB genes were distributed in the HD-Zip subfamilies I and II and identified two pairs of putative orthologous proteins in Arabidopsis and chrysanthemum and four pairs of paralogous proteins in chrysanthemum. The software MEME was used to identify 7 putative motifs with E values less than 1e-3 in the chrysanthemum HD-Zip factors, and they can be clearly classified into two groups based on the composition of the motifs. A bioinformatics analysis predicted that 8 CmHB genes could be targeted by 10 miRNA families, and the expression of these 17 genes in response to phytohormone treatments and abiotic stresses was characterized. The results presented here will promote research on the various functions of the HD-Zip gene family members in plant hormones and stress responses.
S‐glutathiolation impairs phosphoregulation and function of cardiac myosin‐binding protein C in human heart failure

Cardiac myosin‐binding protein C (cMyBP‐C) regulates actin‐myosin interaction and thereby cardiac myocyte contraction and relaxation. This physiologic function is regulated by cMyBP‐C phosphorylation. In our study, reduced site‐specific cMyBP‐C phosphorylation coincided with increased S‐glutathiolation in ventricular tissue from patients with dilated or ischemic cardiomyopathy compared to nonfailing donors. We used redox proteomics, to identify constitutive and disease‐specific S‐glutathiolation sites in cMyBP‐C in donor and patient samples, respectively. Among those, a cysteine cluster in the vicinity of the regulatory phosphorylation sites within the myosin S2 interaction domain C1‐M‐C2 was identified and showed enhanced S‐glutathiolation in patients. In vitro S‐glutathiolation of recombinant cMyBP‐C C1‐M‐C2 occurred predominantly at Cys249, which attenuated phosphorylation by protein kinases. Exposure to glutathione disulfide induced cMyBP‐C S‐glutathiolation, which functionally decelerated the kinetics of Ca2+‐activated force development in ventricular myocytes from wild‐type, but not those from Mybpc3‐targeted knockout mice. These oxidation events abrogate protein kinase‐mediated phosphorylation of cMyBP‐C and therefore potentially contribute to the reduction of its phosphorylation and the contractile dysfunction observed in human heart failure. —Stathopoulou, K. , Wittig, I. , Heidler, J., Piasecki, A. , Richter, F. , Diering, S. , van der Velden, J., Buck, F. , Donzelli, S. , Schröder, E. , Wijnker, P. J. M. , Voigt, N. , Dobrev, D. , Sadayappan, S. , Eschenhagen, T. , Carrier, L. , Eaton, P., Cuello, F. S‐glutathiolation impairs phosphoregulation and function of cardiac myosin‐binding protein C in human heart failure. FASEB J. 30, 1849–1864 (2016). www.fasebj. org
A revision of the World Health Organisation psychiatric disability assessment schedule

The burden schizophrenia places on the individual, on the family and on society in general, is determined more by the associated disability rather than the manifest symptoms. Therefore, measurement of disability provides a baseline for evaluating change and directing treatment. This research has two main aims. The primary purpose of this study was to develop and validate a contemporary revision of the World Health Organisation Psychiatric Disability Assessment Schedule (1988). Data used was based on data from the WHO Collaborative Study on Determinants of Outcome of Severe Mental Disorders (Sartorius et al., 1986). The second aim of this study was to develop a methodology for the construction of a psychometrically rigorous instrument. This involved the use of standard, modified and original data checking and analysis techniques and input from content-experts. Results from this process indicated that the criteria and selection of experts is based upon the considered judgement of the researcher that the sum of the advantages of the expert validation process outweigh the disadvantages. This study has two discrete outcomes: The revised DAS can be used to assess disability in schizophrenia, and a "gold standard" methodology which can be applied during instrument development.
Comparison of a Multiplexed Herpes Simplex Virus Type-Specific Immunoglobulin G Serology Assay to Immunoblot, Western Blot, and Enzyme-Linked Immunosorbent Assays

ABSTRACT The human herpes simplex virus (HSV) is highly pathogenic, with infections caused by two distinct antigenic types, HSV-1 and HSV-2. Differentiation of antibodies to these specific antigens can provide useful information for the diagnosis of subclinical or undiagnosed HSV-2 infections, as well as for reducing the risk of maternal transfer of HSV to the neonate. In this study, a multiplex assay capable of concurrent detection of HSV-1 and -2 immunoglobulin G (IgG) antibodies was compared to immunoblot, Western blot, and enzyme-linked immunosorbent assays. Agreement of the multiplex assay was 95% or greater (n = 332) for both HSV-1 and -2 compared to the three assays. Sensitivities for HSV-1 ranged from 94.9 to 97.9%, with specificities of 93 to 97%. For HSV-2, the sensitivity and specificity ranges were 92.6 to 98.9% and 98.3 to 98.7%, respectively. Our studies show that the multiplexed microsphere-based assay offers a sensitive and specific alternative method for the detection HSV-1 and -2 type-specific antibodies. Advantages of the multiplex assay include multiple results per assay, the inclusion of internal controls for each specimen, and higher throughput of results.
Tomo-GENESIS: DLR's tomographic SAR processing system

Recently, several new algorithms for tomographic SAR inversion have been developed by DLR. These algorithms have been integrated into an efficient work flow: a system called Tomo-GENESIS. It consists of three main steps: pre-processing including APS estimation, tomographic processing and point cloud fusion. Final results over the test sites Las Vegas and Berlin are exemplified. 3D reconstructions of buildings are presented including their seasonal and linear deformations at resolution and coverage levels not possible so far.
The Antipsychotic Drug Loxapine Is an Opener of the Sodium-Activated Potassium Channel Slack (Slo2.2)

Sodium-activated potassium (KNa) channels have been suggested to set the resting potential, to modulate slow after-hyperpolarizations, and to control bursting behavior or spike frequency adaptation (Trends Neurosci 28:422–428, 2005). One of the genes that encodes KNa channels is called Slack (Kcnt1, Slo2.2). Studies found that Slack channels were highly expressed in nociceptive dorsal root ganglion neurons and modulated their firing frequency (J Neurosci 30:14165–14172, 2010). Therefore, Slack channel openers are of significant interest as putative analgesic drugs. We screened the library of pharmacologically active compounds with recombinant human Slack channels expressed in Chinese hamster ovary cells, by using rubidium efflux measurements with atomic absorption spectrometry. Riluzole at 500 μM was used as a reference agonist. The antipsychotic drug loxapine and the anthelmintic drug niclosamide were both found to activate Slack channels, which was confirmed by using manual patch-clamp analyses (EC50 = 4.4 μM and EC50 = 2.9 μM, respectively). Psychotropic drugs structurally related to loxapine were also evaluated in patch-clamp experiments, but none was found to be as active as loxapine. Loxapine properties were confirmed at the single-channel level with recombinant rat Slack channels. In dorsal root ganglion neurons, loxapine was found to behave as an opener of native KNa channels and to increase the rheobase of action potential. This study identifies new KNa channel pharmacological tools, which will be useful for further Slack channel investigations.
Vertibles: using vacuum self-adhesion to create a tangible user interface for arbitrary interactive surfaces

We present Vertibles, a set of Tangible User Interface (TUI) objects employing a vacuum-based adhesion effect. This effect allows attaching them to arbitrarily inclined surfaces, bringing the benefit of TUIs to vertical interactive surfaces. In contrast to other vertically attachable TUIs, Vertibles stick to a wide range of surface materials and work with optical as well as electric object tracking techniques for interactive surfaces. We present an overview of approaches for sticking objects onto vertical surfaces, describe the technical principle and properties of our solution, and document implementation details of a number of Vertibles prototypes.
Vulnerability and Growth. Developmental dynamics and differential effects of the loss of an intimate partner in the second half of life. IP 12: Study outline and first results

This working report gives an overview of the Individual Project 12 “Vulnerability and growth. Developmental dynamics and differential effects of the loss of an intimate partner in the second half of life” of the Swiss National Centre of Competence in Research LIVES led by Pasqualina Perrig-Chiello, University of Bern. This longitudinal and interdisciplinary project aims at examining vulnerability and personal growth after a critical life event, namely the break-up of a long-term intimate relationship in the second half of life, be it due to divorce or due to bereavement. In this report we present details about the rationale, the main research questions, the hypotheses and the methods of the study. Special attention is given to the methodological approach. The authors give a first sample description and report on the validity of the data by comparing the sample with Swiss Labour Force Survey and Swiss Health Survey data.
The effect of phenotypic plasticity on evolution in multipeaked fitness landscapes

When facing the challenge of developing an individual that best fits its environment, nature demonstrates an interesting combination of two fundamentally different adaptive mechanisms: genetic evolution and phenotypic plasticity. Following numerous computational models, it has become the accepted wisdom that lifetime acclimation (e.g. via learning) smooths the fitness landscape and consequently accelerates evolution. However, analytical studies, focusing on the effect of phenotypic plasticity on evolution in simple unimodal landscapes, have often found that learning hinders the evolutionary process rather than accelerating it. Here, we provide a general framework for studying the effect of plasticity on evolution in multipeaked landscapes and introduce a rigorous mathematical analysis of these dynamics. We show that the convergence rate of the evolutionary process in a given arbitrary one‐dimensional fitness landscape is dominated by the largest descent (drawdown) in the landscape and provide numerical evidence to support an analogous dominance also in multidimensional landscapes. We consider several schemes of phenotypic plasticity and examine their effect on the landscape drawdown, identifying the conditions under which phenotypic plasticity is advantageous. The lack of such a drawdown in unimodal landscapes vs. its dominance in multipeaked landscapes accounts for the seemingly contradictory findings of previous studies.
Tied multi-rubber band model for camera distance, shape and head movement robust facial recognition

Facial Capturing cannot ensure the stable head and fix the head position as well as accurate camera distance. This variation degrades the face recognition accuracy. For improving the recognition a true estimator is required to cover the camera distance and the head movement impact. This paper presents a rubber characteristics transformation to generate manifold camera distance and facial shape mapping. The work tied three rubbers to achieve estimated facial variation under shape and distance aspects. Rubber length and relative size ratio mapping are applied managing the face over the database. First rubber is placed between the camera and the foremost facial point at perpendicular. Here distance and size ratio variation is done for facial mapping. Second tied rubber is on the person body up to neck for same size level variation. Third rubber tied to represent the head itself with rotational and shape variation. A ring specific change variation is applied head map. All possible shapes are fused to generate the true head image for mapping. These three rubbers collectively provided shapes, direction and distance robust facial recognition. The comparative experimentation is provided against PCA, LDA and PCA-LDA methods for different sample sets taken from Aberdeen Datasets. The experimental results show that the presented work model provided the improvement over the recognition for more than 30%. The experimentation is applied on the individual variation and mix variations sample sets.
Finding your way in qualitative research, E. Henning, W. van Rensburg and B. Smit : book review

Extracted from text . 509 Title: Finding your way in qualitative research Authors: E. Henning, W. van Rensburg and B. Smit Year: 2004 Publisher: Van Schaik ISBN: 0-627-02545-5 (paperback, 179 pages) 'It's like trying to navigate a dangerous, and mainly uncharted raging river, full of hidden currents and submerged rocks, only no-one will give you a boat that doesn't leak. ' This quote, taken from the diary of a postgraduate student attempting to conduct qualitative research for the first time, succinctly and trenchantly summarises the frustration and confusion often faced by 'novice' qualitative researchers. Whilst the use of qualitative methods in conducting research within .
Evaluation of collapsing methods for fault diagnosis

This paper presents two new single stuck-at fault collapsing methods to reduce the number of tests required for fault diagnosis. The impact of the proposed collapsing methods on diagnosis is evaluated in terms of time and space requirements for the diagnosis process. Experimental comparisons on the ISCAS'85 benchmarks demonstrate the impact of the proposed generalization over the traditional fault collapsing method
Broadcast trees for heterogeneous platforms

In this paper, we deal with broadcasting on heterogeneous platforms. Typically, the message to be broadcast is split into several slices, which are sent by the source processor in a pipeline fashion. A spanning tree is used to implement this operation, and the objective is to find the tree, which maximizes the throughput, i.e. the average number of slices sent by the source processor every time-unit. We introduce several heuristics to solve this problem. The good news is that the best heuristics perform quite efficiently, reaching more than 70% of the absolute optimal throughput, thereby providing a simple yet efficient approach to achieve very good performance for broadcasting on heterogeneous platforms.