Miracle-dz/UniFAR-FTUs huggingface dataset:
Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy

Background and purpose: A functional link between seizure‐induced P‐glycoprotein overexpression at the blood–brain barrier and therapeutic failure has been suggested by several studies using rodent epilepsy models and human epileptic tissue. Recently, we reported that interference with the mechanisms that up‐regulate P‐glycoprotein in response to seizure activity might provide a novel approach to control its expression in the epileptic brain. Based on these data, we hypothesized that blocking the appropriate signalling cascade by cyclooxygenase‐2 inhibition should improve brain penetration of antiepileptic drugs and help to overcome drug resistance.
Adaptive Robust Motion/Force Control of Holonomic-Constrained Nonholonomic Mobile Manipulators

In this paper, adaptive robust force/motion control strategies are presented for mobile manipulators under both holonomic and nonholonomic constraints in the presence of uncertainties and disturbances. The proposed control is robust not only to parameter uncertainties such as mass variations but also to external ones such as disturbances. The stability of the closed-loop system and the boundedness of tracking errors are proved using Lyapunov stability synthesis. The proposed control strategies guarantee that the system motion converges to the desired manifold with prescribed performance and the bounded constraint force. Simulation results validate that the motion of the system converges to the desired trajectory, and the constraint force converges to the desired force
Understanding validity issues in international large scale assessments

Purpose – This policy brief, the third in the AERI-NEPC eBrief series “Understanding validity issues around the world”, discusses validity issues surrounding International Large Scale Assessment (ILSA) programs. ILSA programs, such as the well-known Programme of International Student Assessment (PISA) and the Trends in International Mathematics and Science Study (TIMSS), are rapidly expanding around the world today. In this eBrief, the authors examine what “validity” means when applied to published results and reports of programs like the PISA. Design/methodology/approach – This policy brief is based on a synthesis of conference proceedings and review of selected pieces of extant literature. It begins by summarizing perspectives of an invited expert panel on the topic. To that synthesis, the authors add their own analysis of key issues. They conclude by offering recommendations for test developers and test users. Findings – ILSA programs and tests, while offering valuable information, should be read and u.
Designing accounting transaction ontology

Accounting has a very important role in determining the measures taken by the management of company. Accounting transactions ontology construction is an interactive process that requires the collaboration of both ICT and accountant experts. Building accounting transaction ontology can be used as a basis for making knowledge in accounting domain that will be used in accounting intelligent system. This paper describes about designing accounting transaction ontology.
The Adjustment to U.S. Rural College Campuses for Bisexual Students in Comparison to Gay and Lesbian Students: An Exploratory Study

Previous research suggests that sexual minority (lesbian, gay, and bisexual [LGB]) university students face unique challenges during the adjustment to college that their heterosexual peers do not. Furthermore, sexual minority students, and particularly those identifying as bisexual, at rural campuses in the United States may experience additional struggles because of their environment. The authors undertook this study in an attempt to understand the challenges facing LGB students as they transition to college life on rural campuses. A small, exploratory sample of 56 sexual minority participants attending rural colleges in the United States provided data on measures of college adjustment. Using content analysis of qualitative data and correlational analysis of quantitative data, the following themes emerged: challenges making new friends, difficulty with roommates, and when or whether to disclose sexual orientation. Comparisons between sexual minorities (bisexual to homosexual) were also conducted to explore the unique experiences of bisexual individuals.
Mandala Drawing: Facilitating Creative Growth in Children with ADD or ADHD

AbstractUsing a single-subject, multiple-baseline research design, this study investigates the creative growth and behavioral changes precipitated by the work done in art therapy through the employment of the mandala as an active centering device with children who have been diagnosed with Attention-Deficit Disorder (ADD) or Attention-Deficit Hyperactivity Disorder (ADHD), accompanied by a history of impulsivity. During specified intervals of treatment, a drawing was requested, “Draw a person picking an apple from a tree,” and rated according to the guidelines of the Formal Elements Art Therapy Scale (FEATS). Through examination of the drawings and objective findings of this scale, it appears that a visual measurement of creative growth was achieved. Preliminary findings indicate that the mandala exercise has the effect of increasing attentional abilities and decreasing impulsive behaviors over time, allowing for better decision making, completion of task, general growth in developmental level, and an inte.
The influence of bone and marrow on cartilage hypertrophy and degradation during 30‐day serum‐free culture of the embryonic chick tibia

In this study, an organ culture system is defined which demonstrates complete loss of cartilage matrix from embryonic chick tibiae. Efficient loss of the cartilage matrix occurs within 30 days of serum‐free culture only when the intact tibiae containing bone, marrow, and cartilage tissue are cultured. During organ culture nonhypertrophic chondrocytes become hypertrophic and stain positively for type X collagen and alkaline phosphatase. The cartilage loses Safranin O staining, and finally all cartilage matrix disappears leaving the bony collar and marrow cells. If the tibial cartilage is separated from the bony collar and cultured alone in serum‐free medium, the nonhypertrophic chondrocytes also hypertrophy; the matrix loses Safranin O staining; however, some components of the matrix including type X collagen still remain after 30 days. In the presence of serum, the chondrocytes will hypertrophy but cartilage degradation is not evident. The results of this study support the conclusions that (1) hypertrophy is inherently programmed in the chondrocyte and (2) while Safranin O staining of cartilage cultured alone is diminished in serum‐free organ culture, the degradation of cartilage is complete only when bone and marrow are also present. © 1992 Wiley‐Liss, Inc.
Speech enhancement based on robust NMF solved by alternating direction method of multipliers

A robust version of non-negative matrix factorization (RNMF) with generalized Kullback-Leibler divergence designed for the task of unsupervised monaural speech enhancement is proposed. RNMF tackles unsupervised speech enhancement problem through factorizing the magnitude spectrum of mixture into the sum of a non-negative sparse matrix and a non-negative low-rank matrix. The parameters of nonnegative components are estimated through minimizing the reconstruction error defined by the divergence. The closed-from updating formulae of RNMF are derived using alternating direction method of multipliers. Experimental results demonstrated that the proposed algorithm yields superior results compared with the multiplicative updates at the expense of more computational complexity.
Implications for Learning Analytics Tools : A Meta-Analysis of Applied Research Questions

Educators are in need for powerful Learning Analytics tools in order to improve the effectiveness of their courses and to enhance the performance of their students. In order to design such tools, knowledge about teachers‟ interests and research activities is required. In this paper, we present the results of a meta-analysis of case studies described in the conference proceedings of the approved German eLearning conference “Deutsche eLearning Fachtagung Informatik” (DeLFI). By answering the following two questions: „What research questions are teachers asking for improving Technology-Enhanced Learning? ‟ and „Which methods do teachers apply to answer their research questions? ‟, our aim is to help TEL researchers generate indicators which can be used as a basis for Learning Analytics tools.
Inter-cell interference coordination based on softer frequency reuse in OFDMA cellular systems

In this paper, a novel interference coordination scheme based softer frequency reuse (SerFR) to mitigate inter-cell interference in Orthogonal Frequency Division Multiple Access (OFDMA) cellular systems is presented. In OFDMA systems, inter-cell interference is the most important interference source. Inter-cell interference coordination is considered to improve coverage and increase date rate at cell edge. Soft Frequency Reuse (SFR) interference coordination scheme is proposed in 3GPP Long Term Evolution (LTE). But the scheme cause frequency selective scheduling gain loss, and the peak rate for cell edge users is low because the cell edge users only can use a fraction of the entire frequency band. However, in SerFR scheme, cell edge users can use the entire frequency band, so there are more frequency selective scheduling garn and more peak date rate than SFR scheme.
Improving the quantity and quality of attendance data to enhance student retention

This article draws attention to local and global attendance monitoring in higher education. The paper outlines benefits of attendance monitoring for both the individual learner and university, and compares traditional paper‐based attendance monitoring systems with an electronic system piloted in the Business School and School of Technology at the University of Glamorgan. Typical problems associated with attendance monitoring are examined, and both attendance monitoring approaches are evaluated in terms of quantity and quality of data capture. Finally, student views on having attendance closely monitored are evaluated. This paper is of interest to anyone who uses attendance data, particularly for those who work in the field of student retention.
International social-related accountability standards: Using ANT towards a multi-stakeholder analysis

This article illustrates and critically discusses how organizations manage, interact with, and involve stakeholders in social-related international accountability standards through the theoretical lens of actor-network theory. Theorizations on international accountability standards have largely focused on opportunities and problems related to their adoption from a macro-economic or governance perspective. The role of stakeholders and related management practices remain overlooked, with little evidence-based understanding of the interaction between internal and external organizational actors in multi-stakeholder involvement processes. Although overall generally relational approach to conceptualizing stakeholders is not new, this research focuses on the case of a well-known human-resource corporation and the way it involves stakeholders in a social-related accountability standard. The results reveal that gaining stakeholder involvement is a social innovation process supported by a strong network of stakeholders whose interests and agendas are taken into serious consideration by the corporation. The strength and the sustainability of the network established between the company and its stakeholders are subsequently dependent on the way the corporation translates its own interests and those of the stakeholders into common goals.
Swing-up Control of the Acrobot Using a New Partial Linearization Controller Based on the Lyapunov Theorem

In this paper, a design of swing-up controller of an Acrobot is proposed. The Acrobot is a model of a horizontal bar gymnast, it has only one actuator at the joint of both links and is a typical example of a nonlinear underactuated system. Since the robot has a large range of motion, the Acrobot has a highly nonlinear characteristic and swing-up control of the Acrobot is a difficult problem. The Acrobot has a simple structure and its control objective is clear, hence it is used as a controlled object of not only the nonlinear underactuated control problem but also a remote network control problem recently. For swing-up control of the Acrobot, this paper proposes a controller, which uses pumping energy of the first link. In the controller, a newly proposed partial linearization is used. The nonlinear feedback is constructed based on the Lyapunov theorem. The new feature of the proposed partial linearization method is to guarantee that the linearized sub-systems track the time-variant reference function, which is not guaranteed in previous methods. Numerical simulation is performed to show the effectiveness of the proposed method
Did something change? using statistical techniques to interpret service and resource metrics

In a perfect world, one would always know the answer to that question. Unfortunately, nobody works in a perfect world. This paper will explore statistical techniques used to look for deviations in metrics that are due to assignable causes as opposed to the period to period variation that is normally present. Hypothesis Testing, Statistical Process Control, Multivariate Adaptive Statistical Filtering, and Analysis of Variance will be compared and contrasted. SAS code will be used to perform the analysis. Exploratory analysis techniques will be used to build populations for analysis purposes.
Known and potential functions for the SLP‐76 adapter protein in regulating T‐cell activation and development

The hematopoietic adapter protein SLP‐76 is a critical component of multiple biochemical signaling ‘circuits’ in T cells that integrate proximal signaling events initiated by ligation of the T‐cell receptor (TCR) into more distal pathways. Given the important role ascribed to TCR signaling in directing the outcome of thymocyte selection, it seems likely that SLP‐76 may also function in signaling pathways that ultimately impact the establishment of the peripheral T‐cell repertoire. It is generally accepted that the peripheral T‐cell repertoire is selected in large part during T‐cell development in the thymus. Molecular interactions between the TCR and self‐peptide/major histocompatibility complexes expressed on thymic stromal elements dictate the fate of developing thymocytes. Thymocyte survival and further maturation (positive selection) require an active signal delivered to the cell as a consequence of TCR ligation. This raises the intriguing question of how a thymocyte can, for a narrow window of developmental time, obtain responsiveness to self while maintaining tolerance to these same determinants upon export to the periphery. This article reviews the current literature describing SLP‐76‐dependent signaling pathways in mature T cells and developing thymocytes. A potential role for this critical signaling intermediate in integrating signals leading to positive and negative selection of the peripheral T‐cell repertoire is also discussed.
Benchmarks for reasoning with syntax trees containing binders and contexts of assumptions

A variety of logical frameworks supports the use of higher order abstract syntax in representing formal systems. Although these systems seem superficially the same, they differ in a variety of ways, for example, how they handle a context of assumptions and which theorems about a given formal system can be concisely expressed and proved. Our contributions in this paper are two-fold: (1) We develop a common infrastructure and language for describing benchmarks for systems supporting reasoning with binders, and (2) we present several concrete benchmarks, which highlight a variety of different aspects of reasoning within a context of assumptions. Our work provides the background for the qualitative comparison of different systems that we have completed in a separate paper. It also allows us to outline future fundamental research questions regarding the design and implementation of meta-reasoning systems.
A quantitative evaluation of traffic-aware routing strategies

S u n n n a r y In this research, we address a simple question: how much benefit can be achieved by traffic-aware routing of lntemet traffic? Efficient routing on packet-switched networks has attracted considerable ~ h attention from the early days of the Interoet to the present day, yet current routing practice still relies on weighted shortest paths to route traffic, using algorithms that do not take the distribution of traffic demand into account. Compared to trafficaware routing, static muting potentially reduces Internet performance and/or increases operational and infrastructure costs, as networks must overprovision to avoid congestion.
Optimal location and size of SVC and TCSC for multi-objetive static voltage stability enhancement

A Non-dominated Sorting Particle Swarm Optimization (NSPSO) is used to solve a mixed conti uousdiscreet Multi-objective optimization problem witch consist of optimal location and size of Static Var Compensa tors (SVC) and Thyristor Controlled Series Capacitors (TCSC) in order to maximize Static Voltage Stability Margin (SVSM), reduce power losses (PL) and minimize load Voltage Deviations (VD). While finding the optimal location, thermal limits for the lines and voltage limits for the buses are taken as security constraints. The optimization is performed considering two and three objectives for various combinations of FACTS. Simula tions are performed on IEEE 14 test system for optimal locat ion and size of FACTS devices. The obtained results are v ery encouraging and reveal the capability of the method to generate well-distributed non-dominated Pareto front. Keywords—Static voltage stability margin, SVC, TCSC, Multi-objective optimization, Non-dominated Sorting Particle Swarm Optimization.
Unveiling the Content-Centric Features of TCP

Content-centric networks have been proposed as a new network paradigm that is centered around the distribution of content. A key idea of content-centric networks is to address content by name and to enable nodes in the network to respond to content requests. Most proposals for content-centric networks require a "clean slate" approach and a replacement of today's TCP/IP protocol stack, which raises questions about a feasible deployment path. In this paper, we ask the question to which extent the ideas of content-centric networks can be realized on top of today's IP protocol suite. We explore an approach for name-based addressing that extends today's TCP/IP protocols in a fully standard compliant way. We implement our new method in order to demonstrate its feasibility and evaluate the performance of the system using both latency and processing overhead as measures. The obtained results demonstrate that name-based addressing on IP is feasible. We also acknowledge that content-centric networks designed from the ground up go beyond what can be achieved on top of IP.
Background modeling methods for visual detection of maritime targets

We propose a system for real-time detection of maritime targets based on monocular video data. In the absence of a priori knowledge about their appearance, targets are detected implicitly via the statistical modeling of the scene's nonstationary background. A probabilistic treatment regarding target compactness is also presented. The proposed system currently acts as a stand-alone maritime surveillance application, and may also be used as an early detection stage within a larger maritime target tracking framework.
Nursing assistance at the hospital discharge after cardiac surgery: integrative review

The study aimed to analyze the available evidence in the literature on nursing care in the hospital post-cardiac surgery. Data were collected from electronic databases LILACS, SciELO, MEDLINE, via DeCS thoracic surgery, hospital, nursing care, in the period 2001 to 2011. Ten articles were selected that showed the need to develop a plan of nursing discharge focusing on prevention of complications and coping with physical limitations resulting from heart surgery. Thus, the discharge should be considered from the time of admission, with carefully planned actions involving patient and family.
Intramyocardial, Autologous CD34+ Cell Therapy for Refractory Angina

Rationale: A growing number of patients with coronary disease have refractory angina. Preclinical and early-phase clinical data suggest that intramyocardial injection of autologous CD34+ cells can improve myocardial perfusion and function. Objective: Evaluate the safety and bioactivity of intramyocardial injections of autologous CD34+ cells in patients with refractory angina who have exhausted all other treatment options. Methods and Results: In this prospective, double-blind, randomized, phase II study (ClinicalTrials.gov identifier: NCT00300053), 167 patients with refractory angina received 1 of 2 doses (1×105 or 5×105 cells/kg) of mobilized autologous CD34+ cells or an equal volume of diluent (placebo). Treatment was distributed into 10 sites of ischemic, viable myocardium with a NOGA mapping injection catheter. The primary outcome measure was weekly angina frequency 6 months after treatment. Weekly angina frequency was significantly lower in the low-dose group than in placebo-treated patients at both 6 months (6.8±1.1 versus 10.9±1.2, P=0.020) and 12 months (6.3±1.2 versus 11.0±1.2, P=0.035); measurements in the high-dose group were also lower, but not significantly. Similarly, improvement in exercise tolerance was significantly greater in low-dose patients than in placebo-treated patients (6 months: 139±151 versus 69±122 seconds, P=0.014; 12 months: 140±171 versus 58±146 seconds, P=0.017) and greater, but not significantly, in the high-dose group. During cell mobilization and collection, 4.6% of patients had cardiac enzyme elevations consistent with non-ST segment elevation myocardial infarction. Mortality at 12 months was 5.4% in the placebo-treatment group with no deaths among cell-treated patients. Conclusions: Patients with refractory angina who received intramyocardial injections of autologous CD34+ cells (105 cells/kg) experienced significant improvements in angina frequency and exercise tolerance. The cell-mobilization and -collection procedures were associated with cardiac enzyme elevations, which will be addressed in future studies.
Tamper resistant software: extending trust into a hostile environment

In this paper we illustrate how Tamper Resistant Software or TRS, can within a temporal window extend trust into a hostile environment such as mobile devices and set top boxes. We state and reference our approach to TRS and illustrate a high level attack. We currently estimate that it would take a Class II attacker a month to reverse engineer the TRS we can automatically produce from an existing program. This is based on Data Flow encoding only. With Control Flow encoding and improved Data Flow encodings we expect the attack times to exceed a year.