Miracle-dz/UniFAR-FTUs huggingface dataset:
An Integrated Approach for Collection Center Selection in Reverse Logistics

In this paper, a hybrid multi-criteria decision-making (MCDM)-method and mixed integer linear programming (MILP) approach in order to evaluation of the returned products' collectors along with their ordered quantities, is utilized. Firstly, the most important criteria of collection center in the car industry are identified. Then, in order to evaluate these proposed criteria, a hybrid Fuzzy Decision-Making Trial And Evaluation Laboratory (FDEMATEL)- evaluation of mixed qualitative and quantitative data (EVAMIX) approach is applied. By this method, the most important criteria and their weights along with collection centers' score are determined. In addition, an MILP mathematical model is proposed for selection of the best collection center and computation of ordering quantities. An efficient approach for collection center selection and a novel application of combined FDEMATEL, EVAMIX, and MILP model can be considered as the main contributions of this paper. It should be noted that, to measure the performance of this method a recycling company as a case study in Iran has considered which of this firm collects effete tire and ball bearings of cars. Implementation of this case study can be considered as the other contributions of this paper. At last, with help of obtained results the proper collection center and their ordered quantities are computed. In addition, for measure efficiency of the proposed model, some numerical example, in various dimensions is considered. Moreover, the managers of this industry with the help of a simple methodology can choose the appropriate suppliers.
Characterisation of the Binding of Cationic Amphiphilic Drugs to Phospholipid Bilayers Using Surface Plasmon Resonance

The interactions of three cationic amphiphilic drugs (CPZ, AMI, PROP) with phospholipid vesicles comprising DOPC, DMPC, or DSPC were investigated using surface plasmon resonance (SPR). Responses for CAD concentrations in the range 15.625 to 1500 μM were measured. The greatest uptake by each phospholipid bilayer occurred with CPZ. Inclusion of CAD concentrations between 750 and 1500 μM provided evidence for a second nonsaturable binding process, which may arise from intercalation of the drugs within the lipid bilayer. CAD binding was additionally shown to be dependent on membrane fluidity. Responses were initially fitted over a concentration range of 15.625 to 500 μM using a model which incorporated terms for a saturable binding site. This yielded very poor values of KD and nonsensible values of saturation responses. Subsequently, responses were fit to the expression for a model which incorporated terms for both a saturable binding site and second nonsaturable site. Measurable binding affinities (KD values ranged from 170 to 814 μM) were obtained for DOPC and DMPC bilayers which are similar to values reported previously. This work demonstrates that SPR studies with synthetic phospholipid bilayers provide a potentially useful approach for characterising drug–membrane binding interactions and for providing insight into the processes that contribute to drug–membrane binding.
Anonymity,Unlinkability,Unobservability for Routing Protocol in MANETs

Privacy protection of mobile ad hoc networks is more demanding than that of wired networks due to the open nature and mobility of wireless media. In wired networks, one has to gain access to wired cables so as to eavesdrop communications. Privacy-preserving routing is crucial for some ad hoc networks that require stronger privacy protection. In hostile environments, the enemy can launch traffic analysis against interceptable routing information embedded in routing messages and data packets. Allowing adversaries to trace network routes and infer the motion pattern of nodes at the end of those routes may pose a serious threat to covert operations. A number of schemes have been proposed to protect privacy in ad hoc networks. However, none of these schemes offer complete unlink ability or unobservability property since data packets and control packets are still linkable and distinguishable in these schemes. In this paper, we define stronger privacy requirements regarding privacypreserving routing in mobile ad hoc networks. Anonymous key establishment process and route discovery process authenticates the routing paths taken by individual messages. Achieving anonymity is a different problem than achieving data confidentiality. While data can be protected by cryptographic means, the recipient node address and maybe the sender node address of a packet cannot be simply encrypted because they are needed by the network to route the packet.
A survey for selected avian viral pathogens in backyard chicken farms in Finland

ABSTRACT Backyard poultry are regaining popularity in Europe and increased interest in the health and management of non-commercial farms has resulted. Furthermore, commercial poultry farm owners have become concerned about the risk represented by contagious avian diseases that nearby backyard poultry could transmit. Fifty-one voluntary backyard chicken farms were visited between October 2012 and January 2013. Blood samples and individual cloacal swabs were collected from 457 chickens. In 44 farms (86%), one or more of the tested chickens had antibodies against avian encephalomyelitis and chicken infectious anaemia viruses, 24 farms (47%) had chickens seropositive for infectious bronchitis virus, 10 farms (20%) had chickens seropositive for infectious bursal disease virus, six farms (12%) had chickens seropositive for infectious laryngotracheitis virus and two farms (5.4%) had chickens seropositive for avian influenza virus. No farms had chickens seropositive for Newcastle disease virus. Of the 51 farms, five (10%) had chickens positive for coronavirus reverse transcription polymerase chain reaction. A phylogenetic analysis showed that all backyard chicken coronaviruses collected were QX type infectious bronchitis viruses. All chickens tested for avian influenza and Newcastle disease viruses using real time reverse transcription polymerase chain reaction were negative. To our knowledge, there is no evidence to date to suggest that these diseases would have been transmitted between commercial and non-commercial flocks.
IgA antiendomysium antibodies in human umbilical cord sections as a screening test in relatives of patients with celiac disease

We performed the serum IgA antiendomysium antibody (EmA) assay by indirect immunofluorescence on human umbilical cord sections in 86 subjects with celiac disease, in 187 first‐degree relatives of such patients, and in a control group of 68 unrelated subjects, to investigate the suitability of the method in the screening of populations at risk of gluten sensitivity. Conventional EmA assay using monkey esophagus sections was performed in parallel experiments. The results obtained showed a perfpect correlation between the two methods. All the celiac patients and none of the controls were positive for EmA. EmA positivity was also observed in 11 apparently healthy relatives: intestinal biopsy performed in five of them invariably showed villous atrophy and increase of mucosal lymphocytes. Taking into account the low cost of EmA assay on human umbilical cord, especially when compared to monkey esophagus sections, the method is probably suitable and effective in identifying latent, asymptomatic gluten sensitivity in at‐risk populations.
Fast Dissolving Dosage Forms

Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Recently fast dissolving dosage forms have started gaining popularity and acceptance as new drug delivery systems due to their unique properties. They quickly disintegrate and dissolve in the mouth and can be administered without water, making them particularly suitable for paediatric and geriatric patients. Fast dissolving dosage forms include tablets, films and microspheres. Tablets are the most commonly used amongst them. The aim of the present investigation is to analyze and review rapidly dissolving dosage forms.
Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation.

BACKGROUND & AIMS Inducible heat shock proteins (iHsp), Hsp25/27 and Hsp70, play essential roles in protecting cells against stress and, in intestinal mucosal inflammation, potentially lessening the extent and severity of injury. We examined the expression and regulation of iHsp in human and experimental inflammatory bowel diseases (IBD) and in vitro. METHODS iHsp expression and regulation were assessed in normal and IBD colonic biopsy specimens, IL-10(-/-) mice, and young adult mouse colonic epithelial cells by immunohistochemistry, Western blot, and real-time polymerase chain reaction (PCR). Phosphorylation of double-stranded RNA-dependent protein kinase (PKR) and eukaryotic initiation factor-2alpha (eIF-2alpha) was determined by Western blot. RESULTS Hsp25/27 and Hsp70 levels were selectively reduced in areas of active mucosal inflammation associated with human IBD and IL-10(-/-) mice with colitis. Wild-type mice treated in vivo with interferon (IFN)-gamma + tumor necrosis factor (TNF)-alpha also demonstrated reduced colonic Hsp25/27 and Hsp70. In young adult mouse colonic epithelial cells, IFN-gamma+TNF-alpha inhibited heat induction of Hsp25/27 and Hsp70, an effect not associated with changes in iHsp messenger RNA or protein half-lives but caused by suppressed de novo iHsp synthesis. IFN-gamma+TNF-alpha cotreatment activated PKR, resulting in phosphorylation and inactivation of eIF-2alpha, an essential factor in protein translation. These effects were not due to induced apoptosis and could be negated by PKR-inhibitor and short interfering RNA to PKR. Increased phosphorylation of PKR and eIF-2alpha were also observed in active IBD tissues. CONCLUSIONS Mucosal inflammation is associated with iHsp down-regulation, an effect that appears mediated by translational down-regulation by proinflammatory cytokines. In the context of IBD, we propose that this mechanism contributes to the severity, extent, and persistence of inflammation-induced mucosal injury.
Small and Medium‐Sized Enterprises' Collaborative Buyer–Supplier Relationships: Boundary Spanning Individual Perspectives

Boundary‐spanning individuals (BSIs) play a critical role in supply chain management, especially in small and medium‐sized enterprises (SMEs) where interactions with buyers and suppliers can depend heavily on just a few individuals. This study, utilizing data from Korean manufacturing‐sector SMEs, explores whether cooperative social value orientations of SMEs' BSIs influence the effects of collaborative buyer‐supplier initiatives. The results suggested that the performance implication of decision‐sharing initiative increases when BSIs have a high level of cooperative social value orientation. However, it also negatively moderates the relationship between risk/benefit sharing (involving financial losses or gains) and performance suggesting possible negative side effects. However, we found that such orientation also negatively moderates the relationship between risk/benefit sharing (involving direct financial losses or gains) and relationship performance suggesting possible negative side effects.
Forecast Evolution in the Final Order Problem with Product Returns

We consider the final order problem of a spare parts provider who faces customer demands and receives product returns. The returns can be remanufactured for reuse, or can be disposed. There are forecasts for both demands and returns over the remainder of the product life. We consider an evolution of forecasts and examine its influence on remanufacturing policies and costs. We prove the structure of the optimal policy. Using stochastic dynamic programming, we find the following results: (i) In many instances, there exists a flexibility effect of forecast evolution. Under this effect, we place larger final orders and keep more returns than without forecast evolution. This gives us the ability to respond to new information. (ii) There is a pull-away-from-center effect when there is no forecast update. If we can update the forecasts, then the last buy quantity is less sensitive to the costs, i.e. we buy less at lower costs and more at higher costs compared to the last buy without a forecast update. In a numerical study, we find that a consideration of forecast evolution yields significant cost savings, especially if we have time-dependent demands. The largest part of the savings is obtained from updating the demand forecasts; updating the return forecasts has only a small influence.
Plasma Amprenavir Pharmacokinetics and Tolerability following Administration of 1,400 Milligrams of Fosamprenavir Once Daily in Combination with either 100 or 200 Milligrams of Ritonavir in Healthy Volunteers

ABSTRACT Once-daily (QD) fosamprenavir (FPV) at 1,400 mg boosted with low-dose ritonavir (RTV) at 200 mg is effective when it is used in combination regimens for the initial treatment of human immunodeficiency virus infection. Whether a lower RTV boosting dose (i.e., 100 mg QD) could ensure sufficient amprenavir (APV) concentrations with improved safety/tolerability is unknown. This randomized, two 14-day-period, crossover pharmacokinetic study compared the steady-state plasma APV concentrations, safety, and tolerability of FPV at 1,400 mg QD boosted with either 100 mg or 200 mg of RTV QD in 36 healthy volunteers. Geometric least-square (GLS) mean ratios and the associated 90% confidence intervals (CIs) were estimated for plasma APV maximum plasma concentrations (Cmax), the area under the plasma concentration-time curve over the dosing period (AUC0-τ), and trough concentrations (Cτ) during each dosing period. Equivalence between regimens (90% CIs of GLS mean ratios, 0.80 to 1.25) was observed for the plasma APV AUC0-τ (GLS mean ratio, 0.90 [90% CI, 0.84 to 0.96]) and Cmax (0.97 [90% CI, 0.91 to 1.04]). The APV Cτ was 38% lower with RTV at 100 mg QD than with RTV at 200 mg QD (GLS mean ratio, 0.62 [90% CI, 0.55 to 0.69]) but remained sixfold higher than the protein-corrected 50% inhibitory concentration for wild-type virus, with the lowest APV Cτ observed during the 100-mg QD period being nearly threefold higher. The GLS mean APV Cτ was 2.5 times higher than the historical Cτ for unboosted FPV at 1,400 mg twice daily. Fewer clinical adverse drug events and smaller increases in triglyceride levels were observed with the RTV 100-mg QD regimen. Clinical trials evaluating the efficacy and safety of FPV at 1,400 mg QD boosted by RTV at 100 mg QD are now under way with antiretroviral therapy-naïve patients.
Knowledge Management for Health Care and Long-Term Care in the Technology-Organization-Environment Context

The objective of this chapter is to propose a framework examining the impacts of technological, organizational and environmental factors on the innovation adoption of knowledge management (KM) in long-term care context. This chapter begins with the definition, rationale and importance of KM. Secondly, KM stories, KM in long-term care, prior frameworks in long-term care and knowledge barriers in health care settings will be reviewed. Furthermore, the KM for long-term care in Technology-Organization-Environment (TOE) framework is discussed and proposed. The technology dimension includes security, complexity and costs. Besides, organizational dimension is composed of top management support, firm size, nursing leadership and the readiness. For environmental dimensions, this chapter will focus on competitive pressure and vendor support. As KM is proven to understand performance in long-term care organizations, the proposed framework provides insight to health care organization leaders on how to enhance the effectiveness of KM system.
Performance of a Medium Size, Constant Superheating PC-Controlled Expansion Valve for Chillers

A electronic expansion valve, developed by authors was tested in a chiller test bench and its performance compared with a similar thermostatic expansion valve. A PC operated PID control was used, using constant superheating as control strategy. The experimental results obtained suggest that the use of electronic valves can increase the COP in chillers due mainly to the increase of cooling capacity, was also observed good stability when chiller was submitted to changes in operational conditions. IN1RODUCTION In 1988, Brazil consumed 7,6 % of the total electric energy demand [1] for commercial and residential air conditioning and refrigeration. Taking into account that Brazil is in a world scale one of the countries that makes less intensive use of refrigeration systems, it means that a thoughtful analysis of best use and control of these systems is always required. One topic recently explored for control and optimal operation of refrigeration systems is the performance of expansion valves. Most of the research works deals with modelling of expansion valves, using orifice similarity models [2], [3], [4], [5]; in 1971, Najork [6] and in 1982 Broersen [7] studied thermostatic valves dynamic behaviour, in 1986, Van der Meer and Touber [8] published an accurate study about mass flow rate control problems; later in 1987 Van der Meer [9] analyzed control problems related to mass flow rate in vapour compression chilling systems (VCCS); recent works [10], [11] have also studied control of expansion valves towards a better operation of VCCS; the authors of this work observed that new ways of controlling expansion valves are an open door in nowadays research. This paper deals with the experimental analysis of a medium size, constant superheating, PC controlled expansion valve working in a VCCS system, comparing its operation with that of a conventional thermostatic expansion valve (TEV). ELECIRONIC EXJ;-ANSION VALVE PROTOTYPE DEVELOPED (EEVP) Figure [1] shows the scheme of the electronic expansion valve prototype developed and built by the authors, it is driven by a screw coupled to a step motor. The orifice diameter used is 2 mm, the pointer is a 30° conic shape, the step motor is characterized by 200 steps/round, and the screw used has a step of 0.8 rom/round; from totally close position to completely open, the valve is able to give 4.66 rounds.
The Investment Performance of Green versus Non-Green Stocks: A Cross-Sectional Analysis

The purpose of the research was to compare the investment performance of green and non-green stocks across four investment styles. Recent literature suggests a lack of consensus among researchers in respect of the performance of green investing, Environmental, Social and Governance (ESG) issues, or Socially Responsible Investing (SRI) relative to more traditional forms of investing. Previous research has focused predominantly on the performance of funds thereby taking into account the skills of fund managers in selecting stocks. Additionally, the existing literature’s focus has been on SRI relative to traditional investing or green relative to SRI investing. This research therefore contributes to closing a gap in the literature by investigating the performance of green stocks versus non-green stocks in the market. Monthly investment returns of green portfolios for four investment styles were compared to their non-green equivalent, over four different time periods. Time weighted returns and Sharpe ratios, to measure risk-adjusted returns, were also computed for further analysis. The research indicated that there was no significant difference between the monthly returns of green portfolios versus non-green portfolios in the four investments styles over all periods investigated. Time weighted returns showed that green portfolios outperformed non-green portfolios in 14 of the 16 style/periods investigated. The Sharpe ratios showed risk-adjusted returns were consistent with the findings of the time-weighted returns. However, the non-green value/mid-cap portfolio was the only portfolio to have positive returns and Sharpe ratio for the 2008-2009 crisis period. The importance of the research is to discover performance trends of green and non-green stocks within different investment styles, irrespective of fund manager skill, which may be informative and helpful for investors when choosing which stocks to invest in.
Customer Analysis and Firm Performance in the Polish Insurance Market : Perspective of Customer Profitability and Lifetime Value

The paper attempts to answer the research question whether conducting customer analysis improves firm performance. It presents results of research among Polish insurance agents. According to its findings, conducting customer analysis is positively correlated with firm performance. Other factors that determine firm performance to a large extent are related to economies of scale and established competitive position (i.e. co-workers, low perception of risk related to other channels, agents’ reputation). The use of dedicated CRM software does not influence firm performance. The research results are discussed with the perspective of customer profitability and customer lifetime value.
Selective carotid body ablation in experimental heart failure: a new therapeutic tool to improve cardiorespiratory control

What is the topic of this review? This review summarizes the physiological role played by the carotid body in the autonomic dysregulation and breathing disturbances during the progression of chronic heart failure and the therapeutic potential of carotid body ablation to control cardiorespiratory imbalance and improve survival in heart failure. What advances does it highlight? Carotid body ablation markedly improves breathing stability and normalizes autonomic function in chronic heart failure. More importantly, if carotid body ablation is performed early during the progression of the disease it significantly improves animal survival.
BrainCoqulus : A Formally Verified Compiler of Untyped Lambda Calculus to Brainfuck Thomas Lively Harvard University

We investigate compilation and verification techniques for functional language compilers by developing and verifying BrainCoqulus, a compiler from the untyped call-by-value lambda calculus to brainfuck. The input language is augmented only with a simple output operation and a notion of input using encoded lists of Church numerals, and the output language is assumed to conform to an idealized but reasonable brainfuck semantics. BrainCoqulus is constructed from layers of intermediate languages including a stack machine language used to cross from the functional to imperative paradigm. We use forward simulation to prove that each translation between intermediate languages preserves program semantics, and by transitivity that the entire compilation preserves semantics. Due to time constraints, we finished the end-toend implementation of the compiler in Coq but we were not able to prove all of the compilation correct.