Miracle-dz/UniFAR-FTUs huggingface dataset:
Corruption: what are the effects on government effectiveness? Empirical evidence considering developed and developing countries

Abstract This study analyses the impact of corruption on government effectiveness for a sample of 130 countries. The findings suggest that less-corrupt countries have better quality of public service, better quality in the formulation and adoption of policies and greater credibility and government's commitment to such policies. The findings also suggest that the effect of corruption on government effectiveness is higher in developed countries. Moreover, the estimates also reveal that countries with the most indebted governments and with higher inflation rates have less-efficient governments, and an increase in rule of law represents a good strategy to improve government effectiveness. In turn, regarding developing countries, the findings show that countries with more democratic regimes have a higher degree of government effectiveness.
Development of a TEM Compatible Nanowire Characterization Platform With Self-Forming Contacts

A nanowire characterization platform is designed and fabricated in MEMS-technology for the thermoelectric and structural characterization of single nanowires. The latter is achieved by making the chip compatible to TEM holder, by restricting its thickness to less than 160 μm and its diagonal dimensions to less than 3 mm. Two different fabrication technologies are presented for the realization of such platform, based on a design reproducing the functional requirements. Our first fabrication technique is based on ICP etching, using (100)-silicon wafers, and a subsequent rear grinding. However, as the design includes a vertical wall trench structures, ICP etching of such deep recesses is time-consuming and expensive. Therefore, a second fabrication process is developed, making use of wet-etched (110)-silicon. With these substrates a challenge arises from the intersection of inclined {111} facets. To solve this natural limitation, we introduce a novel fabrication process. Our technique relies on damaging the intersecting {111} planes, to make them etchable again and to produce deeper trenches with vertical walls in a wet-chemical etching process. Additionally, the electrical contacts at the platform are made from porous metal to increase the surface-to-volume ratio, to increase the possibility of a spontaneous electrical contact between the electrodes and nanowires.
Diorganotin(IV) Derivatives of N-Methyl p-Fluorobenzo-Hydroxamic Acid: Preparation, Spectral Characterization, X-ray Diffraction Studies and Antitumor Activity

Three diorganotin(IV) complexes of the general formula R2Sn[RcC(O)N(RN)O] (Rc = aryl, RN = Alkyl) have been synthesized by refluxing in toluene the corresponding diorganotin(IV) oxides with the free ligand N-methyl p-fluorobenzohydroxamic acid, using a Dean and Stark water separator. The ligand was derived from the reaction of the corresponding p-fluorobenzoyl chloride and N-methylhydroxylamine hydrochloride in the presence of sodium hydrogen carbonate. The isolated free ligand and its respective diorganotin compounds have been characterized by elemental analysis, IR and 1H-, 13C-, 119Sn-NMR spectroscopies. The crystal structures of the diorganotin complexes have been confirmed by single crystal X-ray diffraction methods. The investigations carried out on the diorganotin(IV) complexes of N-methyl p-fluorobenzohydroxamic acid confirmed a 1:2 stoichiometry. The complex formation took place through the O,O-coordination via the carbonyl oxygen and subsequent deprotonated hydroxyl group to the tin atom. The crystal structures of three diorganotin complexes were determined and were found to adopt six coordination geometries at the tin centre with coordination to two ligand moieties.
Soleus Neurotomy for Treatment of the Spastic Equinus Foot

OBJECTIVEThis prospective, nonrandomized, noncontrolled study was performed to evaluate the results of a new type of neurotomy, namely the soleus neurotomy, for treatment of the spastic equinus foot. METHODSBetween May 1996 and March 1998, 46 patients were treated for a spastic equinus foot. Clinical status, spasticity (Ashworth Scale score), and kinematic parameters of the gait were determined before and after surgery. The neurotomy was performed on the upper nerve of the soleus in all cases and was associated with other neurotomies (lower nerve of the soleus, 21 patients; gastrocnemius, 9 patients, tibialis posterior, 18 patients; flexor hallucis longus, 16 patients; and flexor digitorum longus, 17 patients). RESULTSThe mean follow-up period was 15 months (range, 8–28 mo). The equinus deformity disappeared clinically in all patients. Before the operation, all patients had an Ashworth Scale score of 2, with an inexhaustible clonus present on knee extension and persisting with knee flexion (Tardieu Scale score, 4), which was abolished in 95% of the patients after surgery. Two patients still had some clonus on knee extension; this did not interfere with their clinical improvement. Knee recurvatum disappeared in eight patients. Analysis of kinematic parameters demonstrated a statistically significant increase in joint motion of the second rocker (P = 0.0026) of the ankle during stance. The duration of the stance or swing phase, length of the walking cycle, and velocity or rate of spontaneous walking were not significantly modified. CONCLUSIONThe study demonstrated that soleus neurotomy is effective for the treatment of spastic equinus foot, leading to abolition of spasticity and improvement in the range of ankle motion during the stance phase of gait.
A hybrid GA-IWO scheduling algorithm

Cloud computing is the latest need of the hour network which is convenient. It is an on-demand network accessed over a shared group of computing resources. Only minimal management effort is needed to be released with no communication with a service-provider. Optimization problem such as Invasive Weed Optimization is used in cloud computing but the challenges in this technique is its premature convergence and cannot achieve global optimum, specifically for multimodal issues. In the case of Genetic Algorithm (GA), it does not always come with global optimum always, mainly the population is varied when overall solution is required. GA is a technique which is complex to be understood. To overcome these drawbacks Genetic Algorithm-Invasive Weed Optimization (GA-IWO) method is proposed. Less computation time is required in GA-IWO and it is easy to implement on embedded systems and this makes the proposed techniques beneficial in the case of real-time decision making situations. Results show that better performance can be achieved through GA-IWO.
Dimensioning optical clouds with shared-path shared-computing (SPSC) protection

Service relocation represents a promising strategy to provide flexible and resource efficient resiliency from link failures in the optical cloud environment. However, when a failure affects a node hosting a datacenter (DC), service relocation from the affected DC is not possible. One alternative to protect against DC failures relies on using design strategies that duplicate the IT (i.e., storage and processing) resources in a backup DC at the expense of increasing resource overbuild (i.e., cost) of the network. This work proposes a dimensioning strategy based on the shared-path shared-computing (SPSC) concept able to protect against any single link, server, or DC failure scenario with minimal resource overbuild for the network and IT infrastructures. SPSC is based on the intuition that only storage units need complete replication in backup DC, while processing units can be instantiated only after the occurrence of a failure, leaving the design strategy some leeway to minimize their number. As result, the proposed SPSC design shows a considerable reduction in the amount of backup resources when compared to the dedicated protection strategies.
Deletion analysis of AGD1 reveals domains crucial for plasma membrane recruitment and function in root hair polarity

ABSTRACT AGD1, a plant ACAP-type ADP-ribosylation factor-GTPase activating protein (ARF-GAP), functions in specifying root hair polarity in Arabidopsis thaliana. To better understand how AGD1 modulates root hair growth, we generated full-length and domain-deleted AGD1-green fluorescent protein (GFP) constructs, and followed their localization during root hair development. AGD1-GFP localized to the cytoplasm and was recruited to specific regions of the root hair plasma membrane (PM). Distinct PM AGD1-GFP signal was first detected along the site of root hair bulge formation. The construct continued to mark the PM at the root hair apical dome, but only during periods of reduced growth. During rapid tip growth, AGD1-GFP labeled the PM of the lateral flanks and dissipated from the apical-most PM. Deletion analysis and a single domain GFP fusion revealed that the pleckstrin homology (PH) domain is the minimal unit required for recruitment of AGD1 to the PM. Our results indicate that differential recruitment of AGD1 to specific PM domains is an essential component of the membrane trafficking machinery that facilitates root hair developmental phase transitions and responses to changes in the root microenvironment. Summary: The spatiotemporal recruitment of AGD1, a plant ACAP-type ARF-GAP, to specific root hair plasma membrane domains is essential for maintaining symmetric tip growth in root hair cells.
Structure and transcription of the Drosophila melanogaster vermilion gene and several mutant alleles

The nucleotide sequence and intron-exon structure of the Drosophila melanogaster vermilion (v) gene have been determined. In addition, the sites of several mutations and the effects of these mutations on transcription have been examined. The major v mRNA is generated upon splicing six exons of lengths (5' to 3') 83, 161, 134, 607, 94, and 227 nucleotides (nt). A minor species of v mRNA is initiated at an upstream site and has a 5' exon of at least 152 nt which overlaps the region included in the 83-nt exon of the major v RNA. The three v mutations, v1, v2, and vk, which can be suppressed by mutations at suppressor of sable, su(s), are insertions of transposon 412 at the same position in exon 1, 36 nt downstream of the major transcription initiation site. Despite the 7.5-kilobase insertion in these v alleles, a reduced level of wild-type-sized mRNA accumulates in suppressed mutant strains. The structure and transcription of several unsuppressible v alleles have also been examined. The v36f mutation is a B104/roo insertion in intron 4 near the splice donor site. A mutant carrying this alteration accumulates a very low level of mRNA that is apparently polyadenylated at a site within the B104/roo transposon. The v48a mutation, which deletes approximately 200 nt of DNA, fuses portions of exons 3 and 4 without disruption of the translational reading frame. A smaller transcript accumulates at a wild-type level, and thus an altered, nonfunctional polypeptide is likely to be synthesized in strains carrying this mutation. (ABSTRACT TRUNCATED AT 250 WORDS)
Tissue-Specific Plantar Fascia-Stretching Exercise Enhances Outcomes in Patients with Chronic Heel Pain: A Prospective, Randomized Study

Background: Approximately 10% of patients with plantar fasciitis have development of persistent and often disabling symptoms. A poor response to treatment may be due, in part, to inappropriate and nonspecific stretching techniques. We hypothesized that patients with chronic plantar fasciitis who are managed with the structure-specific plantar fascia-stretching program for eight weeks have a better functional outcome than do patients managed with a standard Achilles tendon-stretching protocol. Methods: One hundred and one patients who had chronic proximal plantar fasciitis for a duration of at least ten months were randomized into one of two treatment groups. The mean age was forty-six years. All patients received prefabricated soft insoles and a three-week course of celecoxib, and they also viewed an educational video on plantar fasciitis. The patients received instructions for either a plantar fascia tissue-stretching program (Group A) or an Achilles tendon-stretching program (Group B). All patients completed the pain subscale of the Foot Function Index and a subject-relevant outcome survey that incorporated generic and condition-specific outcome measures related to pain, function, and satisfaction with treatment outcome. The patients were reevaluated after eight weeks. Results: Eighty-two patients returned for follow-up evaluation. With the exception of the duration of symptoms (p < 0.01), covariates for baseline measures revealed no significant differences between the groups. The pain subscale scores of the Foot Function Index showed significantly better results for the patients managed with the plantar fascia-stretching program with respect to item 1 (worst pain; p = 0.02) and item 2 (first steps in the morning; p = 0.006). Analysis of the response rates to the outcome measures also revealed significant differences with respect to pain, activity limitations, and patient satisfaction, with greater improvement seen in the group managed with the plantar fascia-stretching program. Conclusions: A program of non-weight-bearing stretching exercises specific to the plantar fascia is superior to the standard program of weight-bearing Achilles tendon-stretching exercises for the treatment of symptoms of proximal plantar fasciitis. These findings provide an alternative option to the present standard of care in the nonoperative treatment of patients with chronic, disabling plantar heel pain. Level of Evidence: Therapeutic study, Level I-1a (randomized controlled trial [significant difference]). See Instructions to Authors for a complete description of levels of evidence.
A novel avian hypothalamic peptide inhibiting gonadotropin release.

The neuropeptide control of gonadotropin secretion at the level of the anterior pituitary gland is primarily through the stimulatory action of the hypothalamic decapeptide, gonadotropin-releasing hormone (GnRH), which was originally isolated from mammals and subsequently from non-mammals. To date, however, an inhibitory peptide of gonadotropin release is unknown in vertebrates. Here we show, in a bird, that the hypothalamus also contains a novel peptide which inhibits gonadotropin release. Acetic acid extracts of quail brains were passed through C-18 reversed-phase cartridges, and then the retained material was subjected to the reversed-phase and cation-exchange high-performance liquid chromatography (HPLC). The peptide was isolated from avian brain and shown to have the sequence Ser-Ile-Lys-Pro-Ser-Ala-Tyr-Leu-Pro-Leu-Arg-Phe-NH(2). Cell bodies and terminals containing this peptide were localized immunohistochemically in the paraventricular nucleus and median eminence, respectively. This peptide inhibited, in a dose-related way, gonadotropin release from cultured quail anterior pituitaries. This is the first hypothalamic peptide inhibiting gonadotropin release reported in a vertebrate. We therefore term it gonadotropin-inhibitory hormone (GnIH).
Metal nanojunctions on silicon single nanowire devices

Direct patterning of silicon dioxide by electron beam lithography is used for the definition of metal nanojunction on wires fabricated on silicon on insulator (SOI) substrates. Devices based on a single silicon nanowire as small as 15 nm and several micrometers long are fabricated by means of a top down process based on electron beam lithography, silicon anisotropic etching and thermal oxidation. A metal gate is defined over a nanoscale opening into the silicon dioxide surrounding the wire obtained by means of the electron beam stimulated oxide etching. The behavior of the device like a silicon nanowire junction field effect transistor (SiNW-JFET) is confirmed by the electrical characterization at room temperature.
Effects of product characteristics on the bundling strategy implemented by recommendation systems

Recommendation system becomes popular in recent years, because it provides more information about products which consumers are more likely to be interested in. However, bundling module, as one way of recommendations, does not appear on any product's page. In this paper, we will explore the impact of product characteristics on the bundling strategy implemented by recommendation system. We found that both rank and quantity of comments have positive impacts on the number of bundles. While feedback rate does not play a lead role in this phenomenon, which has conflicts with the conclusion of the previous research.
The Role of the WTO Dispute Settlement Procedure on International Cooperation

The paper examines the role of the WTO dispute settlement procedure (DSP) when trade policies are not observable. Especially, we spotlight the information gathering function of the DSP, which reveals whether or not an accused country has actually de- viated from an international agreement. In a model of imperfect-monitoring, infinitely- repeated game, we find that the existence of the DSP enables two countries to keep lower rates of non-tari barriers and to attain higher levels of expected welfare.
Retiree Welfare and the 2009 Pension Increase: Impacts from an Australian Experiment

The welfare effects from the 2009 increase in the age pension are evaluated using a quasi-experimental, difference-in-difference regression framework. Using microdata to exploit the exogenous and large increase in the single-person pension rate, the research finds significant improvements in the material welfare of single age pensioners. In particular, non-housing and total consumption rose by 7 per cent and 4 per cent, respectively. The effects were amplified among the poorest retirees. The study extends the literature on the welfare benefits of pension programs, and provides evidence that the policy changes were highly effective in lifting the material welfare of the targeted beneficiaries.
Economic effects of tax cooperation in an enlarged European Union

This study evaluates the economic effects of different scenarios of tax cooperation in the enlarged European Union in the framework of a General Equilibrium Model. The study develops scenarios for a common corporate tax base applicable in all EU Member States, for full harmonisation of tax bases and tax rates, and for the exchange of savings information in the context of personal income taxation
Deriving Topology and Sequence Alignment for the Helix Skeleton in Low-Resolution protein Density Maps

Cryoelectron microscopy (cryoEM) is an experimental technique to determine the three-dimensional (3D) structure of large protein complexes. Currently, this technique is able to generate protein density maps at 6-9 A resolution, at which the skeleton of the structure (which is composed of alpha-helices and beta-sheets) can be visualized. As a step towards predicting the entire backbone of the protein from the protein density map, we developed a method to predict the topology and sequence alignment for the skeleton helices. Our method combines the geometrical information of the skeleton helices with the Rosetta ab initio structure prediction method to derive a consensus topology and sequence alignment for the skeleton helices. We tested the method with 60 proteins. For 45 proteins, the majority of the skeleton helices were assigned a correct topology from one of our top ten predictions. The offsets of the alignment for most of the assigned helices were within +/-2 amino acids in the sequence. We also analyzed the use of the skeleton helices as a clustering tool for the decoy structures generated by Rosetta. Our comparison suggests that the topology clustering is a better method than a general overlap clustering method to enrich the ranking of decoys, particularly when the decoy pool is small.
Antibiotic inhibition of the respiratory burst response in human polymorphonuclear leukocytes

Recently we found that certain antibiotics which are markedly concentrated by human polymorphonuclear leukocytes (PMN) failed to kill susceptible, intraphagocytic Staphylococcus aureus, even though cellular drug levels were quite high. The possibility that specific antibiotics might adversely affect phagocyte antibacterial function was considered. Thus, we studied the effects of multiple antibiotics and adenosine, a known modulator of the PMN respiratory burst response, on neutrophil antibacterial function. At nontoxic concentrations, these drugs had no effect on degranulation in stimulated PMN. Adenosine was a potent inhibitor of formyl-methionyl-leucyl-phenylalanine (FMPL)-stimulated superoxide and hydrogen peroxide generation in PMN but produced less inhibition of microbial particle-induced respiratory burst activity. Three of the tested antibiotics, all of which reach high concentrations in phagocytic cells, had a marked modulatory effect on the PMN respiratory burst. Clindamycin, which enters phagocytes by the cell membrane adenosine (nucleoside) transport system, had only a modest effect on FMLP-mediated superoxide production but inhibited the microbial particle-induced response by approximately 50%. Roxithromycin and trimethoprim were efficient inhibitors of PMN superoxide generation stimulated by FMLP and concanavalin A (also inhibited by erythromycin) but had less effect on zymosan-mediated respiratory burst activity. Antibiotics which entered phagocytes less readily had no effect on the respiratory burst response in PMN. These results, as well as those of experiments with inhibitors of cell membrane nucleoside receptors, indicated that the antibiotic effect is mediated through intraphagocytic pathways. The possibility that antibiotic-associated inhibition of the PMN respiratory burst response might alter leukocyte antimicrobial and inflammatory function deserves further evaluation.
Playing Favorites: Tax Incentives and Urban Growth in China, 1978–2010

This study examines whether locationally preferential tax incentives for firms encourage differential urban expansion in China. Using satellite-based data from 1978 to 2009, we find that zones established early tend to have large and persistent effects, and that provincially determined zones have little impact relative to those designated by national authorities. Zones established later tend only to have effects where counties already had an export-advantageous position. We conclude that such policies can encourage differential growth in the presence of significant distortions in the rest of the economy, but become less effective as these distortions are removed. (JEL O18, R58)
Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt

Controlling protein function through posttranslational manipulations has emerged as an attractive complementary technology to existing genetic systems. Often these methods involve developing pharmacological agents to probe protein function without the need to generate a unique compound for each protein family. One common strategy uses small molecules that act as chemical inducers of dimerization by mediating the interaction of two proteins. Herein we report the use of a chemical inducer of dimerization for the development of a posttranslational technology for the manipulation of protein function. This system, split ubiquitin for the rescue of function (SURF), places the complementation of genetically split ubiquitin under the control of rapamycin-induced dimerization of FK506-binding protein and FKBP12-rapamycin-binding protein. Before complementation a “degron” dooms a protein of interest for destruction by the proteasome. Addition of rapamycin results in a proteolytic shunt away from degradation by inducing ubiquitin complementation and cleavage of the protein of interest from the degron. Importantly, the native protein is rescued. We characterized this system with firefly luciferase and went on to apply it to members of three important classes of proteins: proteases (caspase-3), kinases (v-Src), and transcription factors (Smad3). This general strategy should allow for inducible rescue of a variety of proteins in such a way that their native structure and function are maintained.