Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice.

The revelation that many covalent binding estimates are falsely low due to flawed normalization discloses that protection by N-acetyl-L-cysteine against acetaminophen hepatotoxicity is accompanied routinely by a 50 to 80% decline in arylation. Elevated glutathione may be responsible for inhibiting covalent binding but above-normal concentrations have never been demonstrated in vivo after N-acetyl-L-cysteine treatment or separated adequately from other possible hepatoprotective actions including direct reduction of the toxic acetaminophen metabolite by the antidote. This led us to compare the conventional L-isomer of the antidote to its nonphysiologic stereoisomer, N-acetyl-D-cysteine, because the latter should be capable of reducing the toxic metabolite but not of stimulating glutathione biosynthesis. Oral coadministration of N-acetyl-D-cysteine (1200 mg/kg), however, failed in preventing the elevation of serum alanine aminotransferase activity, in decreasing hepatocellular necrosis, in interdicting covalent binding of the toxic metabolite to hepatocellular proteins and in preventing the depletion of liver glutathione caused by 500 mg/kg of acetaminophen. N-acetyl-L-cysteine succeeded in decreasing these measures of acetaminophen hepatotoxicity while driving liver glutathione concentrations 2-3 fold above control values. The L-isomer also increased urinary excretion of glutathione-derived acetaminophen metabolites whereas the D-isomer increased only acetaminophen sulfate excretion and reversed the customary predominance of acetaminophen cysteine over the mercapturic acid conjugate. Liver uptake of N-acetyl-D-cysteine was reflected in organ concentrations 7-fold higher than noted for the L-isomer. (ABSTRACT TRUNCATED AT 250 WORDS)
The Intersection of Ownership and Leadership in Texas Ranch House: Lessons in Leadership for the Family Business

The Intersection of Ownership and Leadership in Texas Ranch House: Lessons in Leadership for the Family Business. (May 2012) Tony Warren Brown, B.S., Texas A&M University; M.S., Texas A&M University; D.V.M., Texas A&M University Chair of Advisory Committee: Dr. Richard L. Cummins A family business often behaves and operates differently than a nonfamilyowned business. Family matters and dynamics can influence organizational health and business sustainability. Accordingly, leadership in a family business can embody challenges that are both different and magnified in comparison to leadership in other businesses. There is a particular requirement of owners of family businesses to structure the interface of family and business in a manner that assures a successful business while accommodating the interests of the family. This case study identifies lessons in leadership. The report embraces an overarching question regarding the roles and functions of an executive-level organizational leader and narrows the analysis to a focus on the application of the leadership lessons learned to the roles and functions of the owner-leader and his spouse in a start-up, family-owned business enterprise. The examined case is the short-lived Cooke Ranch, documented in the television miniseries Texas Ranch House. A family-owned business needs specific contributions from its ownership in order to thrive and endure. Prominent among these contributions are clarity and
Social services to claim legitimacy: comparing autocracies’ performance

ABSTRACT Autocrats cannot rule by repression and co-optation alone, and need to instil some sense of legitimacy in the populace. Lacking democratic legitimacy, and being in shortage of other identity-based sources of diffuse support, legitimation claims in post-Cold War autocracies increasingly rests on rulers’ ability to achieve concrete outcomes, including the improvement of citizen living conditions. However, autocracies differ from each other, and different institutional arrangements could influence a leader’s ability to deliver social services, and chase performance-based legitimation. Accordingly, this article compares the social service performance of different post-Cold War authoritarian regimes. The analysis demonstrates that so-called electoral autocracies outperform single-party and military regimes, although they show a capacity to provide for their citizens that is similar to hereditary regimes. These findings suggest that the legitimacy returns of introducing semi-competitive and participatory institutions could grow exponentially. Besides procedural legitimacy, these institutions could help rulers pursue legitimation through social services.
An Evaluation of a Rape Prevention Program.

This study assessed the effectiveness of an interactive, co-educational date rape prevention program. Participants for the study (n=192, 97% Caucasian) consisted of sorority and fraternity members of a larger midwestern university. Eighty-four individuals were assigned to a control group with the rest making up the intervention group. All subjects answered questions on sexual attitudes, sexual stereotypes, and other issues one week prior to the intervention program, immediately after the program, and again, one month later. The intervention group watched an interactive, improvisational theater performance in which actors portrayed a date'rape. Audience members were.then encouraged by a male/female team of counselors to offer feedback as to how the rape could have been avoided. The actors then replayed the scene, incorporating audience suggestions, and the rape did not occur. When both groups' pretest and immedige post-test scores were compared, those who watched the program, i.e., the intervention group, were less likely to endorse the kinds of rape myths and stereotypic beliefs thought to be :. ssociated with date rape. However, between-group differences were no longer evident in the one month follow up, suggesting that the program did not create lasting change. (RJM) :************************* Reproductions supplied by EDRS are the best that can be made from the original document. ***********************************************i*********************** U.S. DEPARTMENT Of EDUCATION Office of Educational Research and improvement ECJCATIONAL RESOURCES INFORMATION CENTER (ERIC; 0 This document has been reproduced as received from the person or organization originating it 0 Minor changes have been made to improve An Evaluation of a Rape PreventiOn Program reproduction quality Points of view Or Opinions stated", this clacument do not neceSSInly represent official Patricia Frazier, Gale Valtinson, and Suzanne Candela OEM position or policy C? University of Minnesota Department of Psychology CUniversity of Minnesota "PERMISSION TO REPRODUCE THIS Minneapolis, MN 55455 MATERIAL HAS BEEN GRANTED BY Poster presented at the 1993 meetIng of the American Psychological Association, Toronto. Abstract TO THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC). "TO THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC). " The purpose of this study was to evaluate the effectiveness of a coeducational rape prevention program among members of sororities and fraternities. The intervention group (n = 108) participated in an interactive theater program and completed measures of attitudes toward sexual behavior, sex role stereotypes, and dating behaviors one week prior to, and immediately and one month following, the program. The control group (n = 84) completed the same measures at corresponding time periods. Significant between-group differences were evident at the post-test but not the follow-up in the desired direction (i.e., positive change in the intervention group). Implications for programming and future research are discussed.
Optical coherence tomography: Technology and applications

Summary form only given. In the last two decades optical coherence tomography (OCT) has established itself as a unique non-invasive, optical medical diagnostic imaging modality, enabling unprecedented in vivo cross-sectional tomographic visualization of internal microstructure in a variety of biological systems. Ophthalmology has been the most successful and commercially most active medical field for OCT so far, but several other OCT applications, e.g. in cardiology, dentistry, gastroenterology or dermatology, are on the verge of expanding their market comparable to or larger than that of ophthalmology.Especially in the last decade ultrabroad bandwidth light sources as well as spectral/frequency domain OCT detection technology enabled three-dimensional ultrahigh resolution OCT with unprecedented axial resolution, approaching resolution levels of conventional histopathology, enabling optical biopsy of biological tissue. Furthermore emerging swept source laser technologies and parallel or full-field OCT techniques enabled multiple millions of A-scan rates per second, allowing large area OCT scans with high definition sampling, investigation of dynamic processes or four-dimensional (3D over time) imaging. In addition, extensions of OCT are under development that should provide enhanced contrast or non-invasive depth resolved functional imaging of the investigated tissue, including extraction of birefringent, spectroscopic, blood flow or physiologic tissue information. These extensions of OCT should not only improve image contrast, but should also enable the differentiation and early detection of pathologies via localized functional state. Recently OCT has also been combined with different complementary imaging technologies (photoacoustics, CARS, multi-photon microscopy, fluorescent imaging, ultrasound, adaptive optics) to hybrid/multi-modal approaches to compensate fundamental limits of OCT in order to significantly enhance its performance towards molecular imaging.
Against Intellectual Monopoly

Thank you very much for reading against intellectual monopoly. As you may know, people have look hundreds times for their chosen readings like this against intellectual monopoly, but end up in harmful downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they juggled with some infectious virus inside their computer. against intellectual monopoly is available in our digital library an online access to it is set as public so you can download it instantly. Our digital library saves in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Merely said, the against intellectual monopoly is universally compatible with any devices to read.
High-Efficiency Device Localization in 5G Ultra-Dense Networks: Prospects and Enabling Technologies

The deployment of future 5G ultra-dense small cell networks provides unprecedented opportunities to create an advanced localization system that meets the demands of future location-based services and functionalities. In this paper, we present technical enablers for obtaining location information of user nodes (UNs) in a network-centric manner. More specifically, we focus on signal properties, access node (AN) hardware and AN deployments in the envisioned 5G systems. Moreover, we provide illustrative examples of the expected localization performance and indicate how to efficiently predict the UN location. Finally, we offer insights into the utilization of location-awareness and location prediction, and show that it provides substantial benefits compared to existing radio networks.
Decreased memory performance in healthy humans induced by stress-level cortisol treatment.

BACKGROUND Glucocorticoids (GCs) can regulate hippocampal metabolism, physiologic functions, and memory. Despite evidence of memory decreases during pharmacological GC treatment, and correlations between memory and cortisol levels in certain disease conditions, it remains unclear whether exposure to the endogenous GC cortisol at levels seen during physical and psychological stress in humans can inhibit memory performance in otherwise healthy individuals. METHODS Randomized, double-blind, placebo-controlled comparison of 2 fixed oral doses of cortisol (40 mg/d and 160 mg/d using split doses to approximate circadian rhythm) given for 4 days to matched groups of healthy subjects (n = 51). Lower-dose treatment approximated cortisol exposure during mild stress, whereas the higher dose approximated cortisol exposure during major stress. Cognitive testing and plasma sampling were done at baseline, after 1 and 4 days of treatment, and after a 6-day washout period, hypothesizing dose-dependent decreases in verbal declarative memory. RESULTS Cortisol treatment at the higher dose produced reversible decreases in verbal declarative memory without effects on nonverbal memory, sustained or selective attention, or executive function. A significant interaction between time and treatment condition for paragraph recall was explained by treatment-induced differences in performance after 4 treatment days, with lower immediate and delayed recall performance during higher-dose cortisol treatment compared with lower-dose treatment and placebo. CONCLUSIONS Several days of exposure to cortisol at doses and plasma concentrations associated with physical and psychological stress in humans can-similar to pharmacological GC treatment-reversibly decrease specific elements of memory performance in otherwise healthy individuals.
Early vascular aging and the role of central blood pressure

Vascular aging is described as a gradual process involving biochemical, enzymatic, and cellular changes of the vasculature and modification of the signals that modulate them. On the basis of this conception a new pathophysiological model for deeper understanding of cardiovascular risk and its treatment was introduced. The idea of early vascular aging, that is the acceleration of vascular aging seems to be a promising tool for clinical guidance in individuals at increased cardiovascular risk or a strong family history of early cardiovascular manifestations. Increased arterial stiffness, dilation of central elastic arteries, impaired endothelial function and vasodilatation are dominant aspects of this premature process.
Brazilian grid-connected photovoltaic inverters standards: A comparison with IEC and IEEE

This paper discusses the Brazilian photovoltaic grid-connected inverters standard comparatively with their European and North American counterparts. The electrical characteristics between the photovoltaic grid-connected inverter system and the electrical distribution network, required by the ABNT NBR 16149 standard, are described in detail. A comparison with its related standards in Europe (IEC Std. 61727) and United States (IEEE Std. 1547) is carried out, and finally is presented the standards implications.
Office of the First Minister and Deputy First Minister (OFMDFM)

It is a Department with responsibilities which include the Programme for Government, economic policy, EU affairs and equality and human rights, all within Northern Ireland. Sector: General Address: Block A, Castle Buildings, Stormont, Belfast, Antrim, BT4 3SR Phone: +44 (0)28 9052 8400 Email:
Influence of traditional Chinese medicine on spermatozoa infected in vitro with Escherichia coli

Escherichia coli (E. coli) is the most common cause of urogenital infection and is implicated in genesis of male infertility. In this in vitro study, the influence of traditional Chinese medicine (TCM)‐Qinglishengjing pills on spermatozoa infected in vitro with E. coli was studied. Semen samples were prepared by standard technique and sperm suspension was coincubated respectively with E2888 EARLE’S (group A as normal control), E. coli suspension (group B), mixture of E. coli suspension and TCM (group C) and mixture of E. coli suspension and Furadantin (group D) in vitro. After coincubation, motility parameters, phosphatidylserine (PS) externalisation and morphology of spermatozoa were evaluated. No significant difference between the group C and group A was found in sperm motility parameters (P > 0.05), whereas difference between group B and group A was significant after 2 h (P < 0.05) and 4 h (P < 0.01). Mixed agglutination and ultrastructure damage could be observed in group B and no apparent similar agglutination and ultrastructure damage were observed in other groups. There was no difference in PS externalisation per cent between the groups A and C (P > 0.05) and there was significant difference between the groups A and D, A and B, B and D, C and D (P < 0.01). TCM‐Qinglishengjing pills could reverse E. coli effects on spermatozoa in vitro.
Application of support vector machine with simulated annealing algorithm in MBR membrane pollution prediction

In order to predict the MBR membrane flux more accurately, this paper studies the various models in the field of MBR, and it is difficult for the traditional neural network model to fall into the local minimum in the MBR film pollution application [1] The model of MBR film pollution prediction based on SA-SVM is established by using simulated annealing algorithm and support vector machine. In this paper, we first use the simulated annealing algorithm to search the three important parameters of the support vector machine, the insensitive coefficient and the kernel parameters, and then use the obtained optimal parameters as the initial parameters of the support vector machine and establish the MBR membrane pollution prediction model Finally, the factors influencing membrane fouling were analyzed by principal component analysis (PCA), and the main influencing factors were selected as the input of the model and the size of membrane flux as output. The experimental results show that the prediction model of MBR membrane contamination based on SA-SVM has better fitting effect and higher prediction accuracy than the previous GA-SVM model in membrane flux prediction.
MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer.

BACKGROUND Several lines of evidence have suggested that estrogen receptor alpha (ERalpha)-negative breast tumors, which are highly aggressive and nonresponsive to hormonal therapy, arise from ERalpha-positive precursors through different molecular pathways. Because microRNAs (miRNAs) modulate gene expression, we hypothesized that they may have a role in ER-negative tumor formation. METHODS Gene expression profiles were used to highlight the global changes induced by miRNA modulation of ERalpha protein. miRNA transfection and luciferase assays enabled us to identify new targets of miRNA 206 (miR-206) and miRNA cluster 221-222 (miR-221-222). Northern blot, luciferase assays, estradiol treatment, and chromatin immunoprecipitation were performed to identify the miR-221-222 transcription unit and the mechanism implicated in its regulation. RESULTS Different global changes in gene expression were induced by overexpression of miR-221-222 and miR-206 in ER-positive cells. miR-221 and -222 increased proliferation of ERalpha-positive cells, whereas miR-206 had an inhibitory effect (mean absorbance units [AU]: miR-206: 500 AU, 95% confidence interval [CI]) = 480 to 520; miR-221: 850 AU, 95% CI = 810 to 873; miR-222: 879 AU, 95% CI = 850 to 893; P < . 05). We identified hepatocyte growth factor receptor and forkhead box O3 as new targets of miR-206 and miR-221-222, respectively. We demonstrated that ERalpha negatively modulates miR-221 and -222 through the recruitment of transcriptional corepressor partners: nuclear receptor corepressor and silencing mediator of retinoic acid and thyroid hormone receptor. CONCLUSIONS These findings suggest that the negative regulatory loop involving miR-221-222 and ERalpha may confer proliferative advantage and migratory activity to breast cancer cells and promote the transition from ER-positive to ER-negative tumors.
LibsensorPy: A Library to Improve the Development of Ubiquitous Applications on Raspberry Pi

Commonly, programmers who have no knowledge in elec- tronics, and engineers, who have no programming experi- ence, are involved in projects that aims to build ubiquitous systems. To create such systems, they often face the prob- lem of not having the specific knowledge to deal with activ- ities like: implement system's abstractions, configure logic connections between sensors and a computer device, cap- ture, understand and process data from sensors in order to make them understandable, etc. To fill this gap, this pa- per presents a library named LibsensorPy, an extensible li- brary which allows to abstract much of the complexity of these activities and more easily interact with an environ- ment through sensors and actuators coupled to a Raspberry Pi computer.
Vascular Smooth Muscle Mineralocorticoid Receptor Contributes to Coronary and Left Ventricular Dysfunction After Myocardial Infarction

Mineralocorticoid receptor (MR) antagonists slow down the progression of heart failure after myocardial infarction (MI), but the cell-specific role of MR in these benefits is unclear. In this study, the role of MR expressed in vascular smooth muscle cells (VSMCs) was investigated. Two months after coronary artery ligation causing MI, mice with VSMC-specific MR deletion (MI-MRSMKO) and mice treated with the MR antagonist finerenone (MI-fine) had improved left ventricular compliance and elastance when compared with infarcted control mice (MI-CTL), as well as reduced interstitial fibrosis. Importantly, the coronary reserve assessed by magnetic resonance imaging was preserved (difference in myocardial perfusion before and after induction of vasodilatation, mL mg −1 min−1: MI-CTL: 1.1±0.5, nonsignificant; MI-MRSMKO: 4.6±1.6 [P<0.05]; MI-fine: 3.6±0.7 [P<0.01]). The endothelial function, tested on isolated septal coronary arteries by analyzing the acetylcholine-induced nitric oxide-dependent relaxation, was also improved by MR deletion in VSMCs or by finerenone treatment (relaxation %: MI-CTL: 36±5, MI-MRSMKO: 54±3, and MI-fine: 76±4; P<0.05). Such impairment of the coronary endothelial function on MI involved an oxidative stress that was reduced when MR was deleted in VSMCs or by finerenone treatment. Moreover, short-term incubation of coronary arteries isolated from noninfarcted animals with low-dose angiotensin-II (10−9 mol/L) induced oxidative stress and impaired acetylcholine-induced relaxation in CTL but neither in MRSMKO nor in mice pretreated with finerenone. In conclusion, deletion of MR in VSMCs improved left ventricular dysfunction after MI, likely through maintenance of the coronary reserve and improvement of coronary endothelial function. MR blockage by finerenone had similar effects.
The Relationship Between High Education Unemployment and Macroeconomic Variables in Malaysia.

This study investigates the relationship between High Education Unemployment and Macroeconomic Variables ( gross domestic product, inflation, exchange rate and foreign direct investment ) in Malaysia. In this study, the time period we used is 33 years that is from 1982 to 2014. The methods that we used to conduct in this research is Augmented Dickey-Fuller (ADF) test and PhillipsPerron (PP) which is to examine the stationary of the data. Besides, we used the Johansen cointegration to test the long run relationship of the data. Moreover, Vector Error Correction Model (VECM), Variance Decomposition and Impulse – response Function are been conducted. The main finding of this study is all the independent variables have long run relationship with High Education Unemployment in Malaysia. The gross domestic product and foreign direct investment have negative relationship while the inflation and exchange rate have positive relationship with the high education unemployment in Malaysia. The relationship between high education unemployment and macroeconomic variables in Malaysia Page 1 Chapter 1: Research Overview