Miracle-dz/UniFAR-FTUs huggingface dataset:
Robust guaranteed cost control for a class of large scale networked control systems

In this paper a decentralized guaranteed cost control for a class of interconnected large scale networked control system is presented. For this purpose a local state feedback controller is designed for each system. There is high interconnection between each subsystem. The control loop of each subsystem is closed via communication network. Packet Loss, network induced delay and delays at interconnected states are considered in problem formulation. New sufficient conditions for the existence of guaranteed cost controllers are proposed by introducing a Lyapunov-Krasovskii functional. An explicit expression for the desired robust decentralized local state feedback control law is also given. Finally, numerical example shows the efficiency of proposed method in comparison with conventional controls.
Systematic characterization of porcine ileal Peyer’s patch, II. A role for CD154 on T cells in the positive selection of immature porcine ileal Peyer’s patch B cells

We previously demonstrated that the majority (≥ 90%) of porcine ileal Peyer’s patch (IPP) follicular cells are immature B cells destined to die by apoptosis, when incubated at 37°. In this paper we approached the mechanisms responsible for positive selection of porcine IPP follicular immature B‐cell selection, by screening for various cell types, cytokines and polyclonal and monoclonal antibodies for promoting the survival of IPP B cells. Of these reagents, only CD3 cross‐linked purified T cells from mesenteric lymph nodes were able to rescue IPP follicular B cells from apoptosis, although polyclonal anti‐IPP lymphocyte antibodies delayed apoptosis. This survival effect could be reproduced simply by incubating IPP follicular B cells with soluble and cell membrane‐expressed CD154, an observation consistent with the demonstrated presence of CD40 and CD154 on porcine IPP follicular B cells and activated T cells, respectively. The IPP follicular B cells rescued in this manner expressed a more mature surface marker phenotype. Immunohistology and fluorescence‐activated cell sorter analysis demonstrated that subpopulations of IPP follicular T cells (less than 0·5%) express CD154. Thus, perhaps unexpectedly, CD154 on T cells may play a role in the positive selection of immature B cells in the porcine IPP. The origin and control of the activated T cells identified within the porcine IPP remains to be investigated.
Effect of innervation‐zone distribution on estimates of average muscle‐fiber conduction velocity

Muscle‐fiber conduction velocity (MFCV) may be a diagnostic variable, but the factors affecting its estimate from surface electromyographic (SEMG) signals are still not fully understood. We investigated the effect of innervation‐zone distribution on estimates of average MFCV from simulated SEMG signals. Single‐fiber action potentials were simulated using a computer model that describes an idealized cylindrical volume conductor comprised of bone, muscle, subcutaneous, and skin tissues. A model describing the characteristics and control of a motor‐neuron pool was used to simulate 60 s of SEMG. Five innervation‐zone distributions, inclined with respect to the fiber direction, were simulated within the muscle tissue, based on data from the literature and an experimental analysis. Two parameters were varied concurrently: (1) excitation level (5%–100%, 5% increments); and (2) subcutaneous tissue thickness (4 and 10 mm). The MFCV estimates were affected by the distribution of innervation zones with bias varying with excitation level and thickness of subcutaneous tissue. The MFCV estimates ranged from 3.95 to 11.67 m/s for single‐differential and from 3.99 to 5.23 m/s for double‐differential recordings when all simulated motor units were assigned the same conduction velocity of 4 m/s. Amplitude and characteristic spectral frequencies were also influenced by the distribution of innervation zones. The effect of innervation‐zone distribution on MFCV estimates is thus substantial and may be a significant confounding factor in experimental and clinical studies on muscles with diffuse innervation zones. Muscle Nerve, 2007
Mesure inertielle pour l'analyse du mouvement humain. Optimisation des méthodologies de traitement et de fusion des données capteur, intégration anatomique

Face aux limites auxquelles doivent faire face les systemes optoelectroniques (materiel lourd, champ de mesure limite), les capteurs inertiels constituent une alternative prometteuse pour la mesure du mouvement humain. Grâce aux dernieres avancees techniques, notamment en termes de miniaturisation des capteurs, leur utilisation en ambulatoire c’est-a-dire de facon autonome et embarquee est devenue possible. Mais ces operations de miniaturisation ne sont pas sans effet sur les performances de ces capteurs. En effet, une telle mesure est degradee par differents types de perturbations (stochastiques et deterministes) qui sont alors propagees au cours du processus dit de fusion des donnees visant a estimer l'orientation des segments humains. Classiquement, cette operation est realisee a l'aide d'un filtre de Kalman dont le role est justement d'estimer une grandeur a partir d'une mesure bruitee en la confrontant a un modele d'evolution.Dans ce contexte, nous proposons diverses methodologies dans le but d'acceder a une mesure suffisamment precise pour etre exploitee dans le cadre de l'analyse du mouvement humain. La premiere partie de cette these se focalise sur les capteurs. Tout d'abord, nous etudions les bruits de mesure issus des capteurs inertiels, puis nous leur attribuons un modele afin de les prendre en compte au sein du filtre de Kalman. Ensuite, nous analysons les procedures de calibrage et evaluons leurs effets reels sur la mesure afin d'emettre quelques propositions en termes de compromis performance/facilite de realisation.Dans une seconde partie, nous nous consacrons a l'algorithme de fusion des donnees. Apres avoir propose un filtre de Kalman adapte a la mesure du mouvement humain, nous nous focalisons sur un probleme recurrent a ce stade : l'identification des matrices de covariance dont le role est d'attribuer une caracterisation globale aux erreurs de mesure. Cette methode, basee sur une confrontation de la mesure avec une reference issue d'un systeme optoelectronique, met en evidence la necessite de traiter ce probleme rigoureusement.Dans une troisieme partie, nous commencons a aborder les problemes lies a l'utilisation des capteurs inertiels pour la mesure du mouvement humain, notamment le calibrage anatomique et le positionnement des capteurs.En conclusion, les gains apportes par les diverses propositions avancees dans cette these sont evalues et discutes.
Global scaling inductor models with temperature effect

This paper presents global lumped-element circuit models of spiral inductor and differential inductor respectively considering quality factor dependence on temperature. Metal resistance components in equivalent circuits of spiral inductor and differential inductor were adopted to reflect quality factor dependence on temperature in global model. And the global models were shown to give excellent agreement with measured data for inductors of various dimension over temperature range from -40°C to 125°C, which will facilitate customers to design circuits for worst temperature conditions in real world applications.
Telomeric sequences, radiation sensitivity and genomic instability

Purpose : To review the basic features of telomeres with particular emphasis on their potential importance in radiation biology. Recent findings suggest that telomere length can influence radiation sensitivity in mouse and that several human radiosensitive disorders also show abnormalities in telomere dynamics. Numerous studies indicate that telomeric sequences may play a role in determining the stability of certain genomic regions both spontaneously and following irradiation. Furthermore, a number of transmissible genomic instability systems have been described in which it appears that telomere metabolism may be contributing to the delayed effects observed. Features of telomeres and telomere biology relevant to these topics are reviewed. Conclusions : The evidence that telomeres and the molecular pathways of telomere maintenance can play a role in determining the outcome of radiation exposure is now substantial. Thus, the field of telomere biology deserves continued attention from radiobiologists.
An optical metasurface planar camera

Optical metasurfaces are 2D arrays of nano-scatterers that modify optical wavefronts at subwavelength spatial resolution. They are poised to revolutionize optical design by enabling complex low cost systems where multiple metasurfaces are lithographically stacked on top of each other and are integrated with electronics. For imaging applications, metasurface stacks can perform sophisticated image corrections and can be directly integrated with image sensors. Here, we demonstrate this concept with a miniature flat camera integrating a monolithic metasurface lens doublet corrected for monochromatic aberrations, and an image sensor. The doublet lens, which acts as a fisheye photographic objective, has an f-number of 0.9, an angle-of-view larger than 60$^\circ$$\times$60$^\circ$, and operates at 850 nm wavelength with large transmission. The camera exhibits high image quality, which indicates the potential of this technology to produce a paradigm shift in future designs of imaging systems for microscopy, photography and computer vision.
Baseline 6 Clicks + 6 Drags Ours 1 Select + 1 Drag or = Final ResultRotoscoping Intermediate Frame Keyframes

Rotoscoping (cutting out different characters/objects/layers in raw video footage) is a ubiquitous task in modern post-production and represents a significant investment in person-hours. In this work, we study the particular task of professional rotoscoping for high-end, live action movies and propose a new framework that works with roto-artists to accelerate the workflow and improve their productivity. Working with the existing keyframing paradigm, our first contribution is the development of a shape model that is updated as artists add successive keyframes. This model is used to improve the output of traditional interpolation and tracking techniques, reducing the number of keyframes that need to be specified by the artist. Our second contribution is to use the same shape model to provide a new interactive tool that allows an artist to reduce the time spent editing each keyframe. The more keyframes that are edited, the better the interactive tool becomes, accelerating the process and making the artist more efficient without compromising their control. Finally, we also provide a new, professionally rotoscoped dataset that enables truly representative, real-world evaluation of rotoscoping methods. We used this dataset to perform a number of experiments, including an expert study with professional roto-artists, to show, quantitatively, the advantages of our approach. CR Categories: I.3. 7 [Computer Graphics]: Methodology and Techniques—Interaction Techniques; I.4. 1 [Image Processing and Computer Vision]: Scene Analysis—Shape
A table soccer game recorder

Our table soccer robot can already challenge even professional human players. Next, the robot should play games by using human-like skills. As a foundation of this research, our table soccer game recorder can save and replay games played by humans. This video shows the construction and functionality of the recording system. We use three types of sensors mounted on a regular game table. The movement of a game rod is measured by an optical distance sensor. Its turning is observed by a magnetic rotary encoder. Two laser measurement systems are synchronized to determine the position of the ball. The raw sensor data is smoothed by an approach using multi-model Kalman filter. We developed several software modules for the system. The modules provide a basis for the future research.
An algorithm for distinguishing the types of objects on the road using laser radar and vision

Describes a method for distinguishing the types of forward objects detected on and alongside the road using a vehicle-mounted scanning laser radar (SLR) and a camera. This method can measure the distance to a preceding vehicle in the same lane as well as to other forward vehicles in adjacent lanes. Objects are detected on the basis of SLR digital signal data and are categorized as vehicles, delineators, and signs based on their motion and positions relative to white lane markers. The motions of detected objects are judged by the relationship between the path of the host vehicle and changes in the positions of the objects. The host vehicle's path is computed using steering maneuver data and the vehicle velocity. White lane markers are detected by an image processing technique. The proposed algorithm has been validated in an experiment conducted with a simulator. Data recorded at a driving speed of more than 40 km/h on Japanese expressways were used in the simulation. The types of objects detected on the road were successfully distinguished as expected.
Discrete-time parallel robot motion control using adaptive neuro-fuzzy inference system based on improved subtractive clustering

This paper addresses a high precision discrete-time model-free PID adaptive neuro-fuzzy logic motion controller in case the physical models that describe a robot are not known. The advantage of this kind controller is that it uses an improved subtractive clustering technique to obtain the structure of the system model in order to ensure the high accuracy of the intelligent control. Moreover, the information used is directly from the nonlinear system response without the knowledge of the robot physical parameters and complex models. Furthermore, the controller is designed in discrete-time domain for allowing its implementation. To conceive this kind intelligent control, first adaptive neuro-fuzzy inference system with an improved subtractive clustering computing is used to accomplish the integration of information of joint angular displacement and velocity for torque identification. The learning datasets are generated by using a discrete-time PID feedback control, which desired position is sufficiently rich to ensure that the learning system would include most characteristics of the nonlinear dynamics of the system. Then a discrete-time fuzzy feed forward control, combined with a conventional PID and the adaptive neuro-fuzzy inference system, is designed for the mechanism motion control. Simulation results from numerical experiment on a 4-bar planar parallel mechanism show the proposed controller can reduce joint position and velocity tracking errors with higher accuracy and higher reliability than a traditional PID controller and a computed torque controller.
15 d-Prostaglandin J 2 Protects Brain From Ischemia-Reperfusion Injury

Objective—Brain expresses abundant lipocalin-type prostaglandin (PG) D2 (PGD2) synthase but the role of PGD2 and its metabolite, 15-deoxy12,14 PGJ2 (15d-PGJ2) in brain protection is unclear. The aim of this study is to assess the effect of 15d-PGJ2 on neuroprotection. Methods and Results—Adenoviral transfer of cyclooxygenase-1 (Adv-COX-1) was used to amplify the production of 15d-PGJ2 in ischemic cortex in a rat focal infarction model. Cortical 15d-PGJ2 in Adv-COX-1–treated rats was increased by 3-fold over control, which was correlated with reduced infarct volume and activated caspase 3, and increased peroxisome proliferator activated receptor(PPAR ) and heme oxygenase-1 (HO-1). Intraventricular infusion of 15d-PGJ2 resulted in reduction of infarct volume, which was abrogated by a PPAR inhibitor. Rosiglitazone infusion had a similar effect. 15d-PGJ2 and rosiglitazone at low concentrations suppressed H2O2-induced rat or human neuronal apoptosis and necrosis and induced PPAR and HO-1 expression. The anti-apoptotic effect was abrogated by PPAR inhibition. Conclusion—15d-PGJ2 suppressed ischemic brain infarction and neuronal apoptosis and necrosis in a PPAR dependent manner. 15d-PGJ2 may play a role in controlling acute brain damage induced by ischemia-reperfusion. (Arterioscler Thromb Vasc Biol. 2006;26:481-487.)
Comparative activities of several nucleoside analogs against duck hepatitis B virus in vitro

Duck hepatitis B virus (DHBV) replication in primary duck hepatocytes was monitored by examining the synthesis of both DHBV DNA and DHBV core antigen. Several nucleoside analogs which were previously shown to inhibit the replication of DNA viruses (i.e., herpesviruses) and retroviruses were examined for their inhibitory effects on the synthesis of DHBV core antigen in primary duck hepatocytes. (S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA], 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine, 2',3'-dideoxyadenosine, and 2',3'-dideoxycytidine inhibited DHBV core antigen synthesis at concentrations that were significantly lower than those found to be toxic to the primary hepatocytes. Of all the compounds tested, (S)-HPMPA showed the lowest 50% effective concentration (0.5 micrograms/ml). The selectivity index or ratio of the 50% cytotoxic concentration to the 50% effective concentration of (S)-HPMPA was greater than 300. (S)-HPMPA not only inhibited DHBV core antigen but also DHBV DNA synthesis in DHBV-infected hepatocytes.
Chronic streptococcosis in Nile tilapia, Oreochromis niloticus (L.), caused by Streptococcus agalactiae.

1 Key Laboratory for Aquatic Products Safety Department of the Ministry of Education/State Key Laboratory ofBiocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China2 College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China3 Guangdong Provincial Aquatic Animal Epidemic Disease Prevention and Control Center, Guangzhou,Guangdong, China4 Aquaculture Technology Service Station of Zhuhai, Zhuhai, Guangdong, China
A Word Line Pulse Circuit Technique for Reliable Magnetoelectric Random Access Memory

A word line pulse (WLP) circuit scheme is proposed toward the implementation of magnetoelectric random access memory (MeRAM). The circuit improves the write error rate (WER) and cell area efficiency by generating a better write pulse compared to conventional bitline pulse (BLP) techniques in terms of the pulse slew rate and amplitude. For the voltage-controlled magnetic anisotropy-induced precessional switching of the magnetic tunnel junction (MTJ), the write pulse shape has a large impact on the switching probability. Typically, a square shape pulse results in higher switching probability compared to that of a triangular shape pulse with long rise and falling edges, since the square shape pulse causes a more stable precessional trajectory of the free layer magnetization by providing a relatively constant in-plane-dominant effective field. Compared to the BLP scheme, the WLP can generate a better square shape pulse by eliminating discharge paths under the pulse condition, using the gain of the access transistor, and effectively diminishing the capacitive loading which needs to be driven. A macrospin compact model of voltage-controlled MTJ shows that the WLP can improve WER by ${10}^{7}$ times and allow MeRAM to have four-time improvement in area efficiency of driver circuits compared to the BLP.
Clonidine as an adjuvant to local anaesthetic axillary brachial plexus block: a randomized, controlled study.

BACKGROUND We compared the effects of clonidine added to levobupivacaine and bupivacaine on axillary brachial plexus block as well as the effectiveness of levobupivacaine alone compared with bupivacaine alone. METHODS In this prospective, randomized, controlled, double-blind trial, four groups of 20 patients each were investigated, using (i) 40 ml of levobupivacaine 0.5% plus 0.150 mg of clonidine, (ii) 40 ml of levobupivacaine 0.5% plus 1 ml of NaCl 0.9%, (iii) 40 ml of bupivacaine 0.5% plus 0.150 mg of clonidine, and (iv) 40 ml of bupivacaine 0.5% plus 1 ml of NaCl 0.9%, respectively. The onset of motor and sensory block and duration of sensory block were recorded. RESULTS There was no significant difference in duration between groups, but a significantly higher variance (P<0.001) was found in the two groups with clonidine than in the two groups without. CONCLUSIONS These findings suggest responder and non-responder behaviour is a result of the addition of clonidine.
A Role for USP7 in DNA Replication

ABSTRACT The minichromosome maintenance (MCM) complex, which plays multiple important roles in DNA replication, is loaded onto chromatin following mitosis, remains on chromatin until the completion of DNA synthesis, and then is unloaded by a poorly defined mechanism that involves the MCM binding protein (MCM-BP). Here we show that MCM-BP directly interacts with the ubiquitin-specific protease USP7, that this interaction occurs predominantly on chromatin, and that MCM-BP can tether USP7 to MCM proteins. Detailed biochemical and structure analyses of the USP7–MCM-BP interaction showed that the 155PSTS158 MCM-BP sequence mediates critical interactions with the TRAF domain binding pocket of USP7. Analysis of the effects of USP7 knockout on DNA replication revealed that lack of USP7 results in slowed progression through late S phase without globally affecting the fork rate or origin usage. Lack of USP7 also resulted in increased levels of MCM proteins on chromatin, and investigation of the cause of this increase revealed a defect in the dissociation of MCM proteins from chromatin in mid- to late S phase. This role of USP7 mirrors the previously described role for MCM-BP in MCM complex unloading and suggests that USP7 works with MCM-BP to unload MCM complexes from chromatin at the end of S phase.
Impact of Evidence-Based Guidelines on Outcomes of Hospitalized Patients With Clostridium difficile Infection

Objectives Clostridium difficile infection (CDI) is the most common healthcare-associated infection in the United States. Clinical practice guidelines for the treatment of CDI were updated in 2010 by the Society for Healthcare Epidemiology of America and the Infectious Diseases Society of America. An institutional guideline for the classification and management of CDI in accordance with the 2010 Society for Healthcare Epidemiology of America/Infectious Diseases Society of America guideline was developed and provided to attending physicians and medical residents in multiple formats. Methods We sought to determine the impact of an evidence-based guideline for the treatment of CDI at a community teaching hospital. A retrospective chart review was conducted to identify length of stay (LOS), readmission rates, direct cost, mortality, and physician adherence to guidelines in patients with International Classification of Diseases, Ninth Edition codes and laboratory confirmation of CDI between February 1, 2013 and January 31, 2014. Endpoints included LOS after diagnosis of CDI, 30-day readmission rates, direct cost after diagnosis of CDI, and mortality. Results A total of 351 patient encounters were included in the study. Although not statistically significant, it was found that guideline-based therapy (n = 131) was associated with a lower median LOS (6 days vs 8 days; P = 0.06). Thirty-day hospital readmission (25.2% vs 29.5%; P = 0.39) and median cost after diagnosis of CDI ($7238.48 vs $8794.81; P = 0.10) also were lower but not statistically significant. Patients with mild-to-moderate infection were found to have a significantly lower median LOS (5 days vs 7 days; P = 0.03) and median cost after diagnosis ($5257.85 vs $7680.56; P = 0.03) when treated with guideline-based therapy. Overall physician adherence to guidelines was low, at 38%. Conclusions Treatment with guideline-based therapy for CDI was associated with a trend toward a significantly lower LOS and cost. Barriers to physician adherence to guidelines still exist, despite education and guideline availability. Electronic health record–based order sets or clinical decision tools may improve recognition of and adherence to guidelines.