Miracle-dz/UniFAR-FTUs huggingface dataset:
Porphyromonas gingivalis within Placental Villous Mesenchyme and Umbilical Cord Stroma Is Associated with Adverse Pregnancy Outcome

Intrauterine presence of Porphyromonas gingivalis (Pg), a common oral pathobiont, is implicated in preterm birth. Our aim was to determine if the location of Pg within placental and/or umbilical cord sections was associated with a specific delivery diagnosis at preterm delivery (histologic chorioamnionitis, chorioamnionitis with funisitis, preeclampsia, and preeclampsia with HELLP-syndrome, small for gestational age). The prevalence and location of Pg within archived placental and umbilical cord specimens from preterm (25 to 32 weeks gestation) and term control cohorts were evaluated by immunofluorescent histology. Detection of Pg was performed blinded to pregnancy characteristics. Multivariate analyses were performed to evaluate independent effects of gestational age, being small for gestational age, specific preterm delivery diagnosis, antenatal steroids, and delivery mode, on the odds of having Pg in the preterm tissue. Within the preterm cohort, 49 of 97 (51%) placentas and 40 of 97 (41%) umbilical cord specimens were positive for Pg. Pg within the placenta was significantly associated with shorter gestation lengths (OR 0.63 (95%CI: 0.48–0.85; p = 0.002) per week) and delivery via caesarean section (OR 4.02 (95%CI: 1.15–14.04; p = 0.03), but not with histological chorioamnionitis or preeclampsia. However, the presence of Pg in the umbilical cord was significantly associated with preeclampsia: OR 6.73 (95%CI: 1.31–36.67; p = 0.02). In the term cohort, 2 of 35 (6%) placentas and no umbilical cord term specimens were positive for Pg. The location of Pg within the placenta was different between preterm and term groups in that Pg within the villous mesenchyme was only detected in the preterm cohort, whereas Pg associated with syncytiotrophoblasts was found in both preterm and term placentas. Taken together, our results suggest that the presence of Pg within the villous stroma or umbilical cord may be an important determinant in Pg-associated adverse pregnancy outcomes.
Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection1

Background. Dendritic cells secrete a population of “antigen-presenting vesicles,” called exosomes, expressing functional class I and II major histocompatibility complex (MHC) and co-stimulatory molecules. The subcutaneous administration of syngeneic exosomes expressing tumor antigens has been shown to induce specific antitumor immune responses in vivo. The authors hypothesized that antigen presentation by exosomes, depending on the context of their administration, may induce tolerance rather than immunity. Methods. The authors therefore tested the capacity of exosomes derived from donor bone marrow dendritic cells, given before transplantation, to modulate heart allograft rejection. Results. The authors show here that donor type but not syngeneic exosomes induced a significant prolongation of allograft survival, with a few recipients having long-term graft survival. During the first week after transplantation, allografts from exosome-treated rats displayed a significant decrease in graft-infiltrating leukocytes and in the expression of interferon-&ggr; mRNA compared with allografts from untreated animals. Moreover, when tested in vitro, spleen CD4+ T cells from exosome-treated recipients displayed a significant decrease in anti-donor responses, suggesting a decrease in anti-donor T-cell responses. However, the authors also found that allogeneic donor-derived exosomes increased anti-donor MHC class II alloantibody production. Conclusions. The authors demonstrate an effect of allogeneic exosomes on the modulation of immune responses in vivo, suggesting that, like donor cells, exosomes can stimulate or regulate antigen-specific immune responses.
Dermatologic Complications of Dermabond after Orthopaedic Surgery: A CaseReport and Review of the Literature

We present a case of allergic contact dermatitis in a patient after multiple orthopaedic procedures. The patient demonstrated a foreign body reaction as well as classic contact dermatitis in response to two exposures to Dermabond. Both reactions were successfully treated with topical corticosteroids. As the popularity of Dermabond increases within the medical community, awareness of potential complications is necessary to improve patient care and outcomes.
Productivité agricole et rattrapage technologique : le cas des exploitations de grandes cultures du Nord-Pas-de-Calais

Un des principaux objectifs des differentes reformes successives de la PAC est de soumettre davantage l’offre agricole europeenne aux signaux des marches. De fait, la recherche de competitivite devient une preoccupation majeure des agriculteurs. Les moins performants doivent rattraper les plus efficaces en essayant d’adopter progressivement les meilleures pratiques. Notre etude tente de reveler et de mesurer ces eventuels phenomenes de convergence des performances productives entre les exploitations agricoles. Elle porte sur 178 exploitations specialisees en grandes cultures et situees dans un meme bassin de production (Nord-Pas-de-Calais), au cours de la periode 1994-2001 (periode d’application de la reforme Mac Sharry et des premieres mesures d’Agenda 2000). A partir d’estimations des niveaux de la productivite globale des facteurs basees sur la notion de fonction de distance, nos resultats indiquent clairement des processus de rattrapage, a la fois technique, et d’echelle entre les exploitations
Regulation of Indian hedgehog mRNA levels in chondrocytic cells by ERK1/2 and p38 mitogen‐activated protein kinases

Indian hedgehog (Ihh) is produced by growth plate pre‐hypertrophic chondrocytes, and is an important regulator of endochondral ossification. However, little is known about the regulation of Ihh in chondrocytes. We have examined the role of integrins and mitogen‐activated protein (MAP) kinases in Ihh mRNA regulation in CFK‐2 chondrocytic cells. Cells incubated with the β1‐integrin blocking antibody had decreased Ihh mRNA levels, which was accompanied by decreases of activated extracellular signal‐regulated kinases (ERK1/2) and activated p38 MAPK. Ihh mRNA levels were also inhibited by U0126, a specific MEK1/2 inhibitor, or SB203580, a specific p38 MAPK inhibitor. Cells transfected with constitutively active MEK1 or MKK3 had increased Ihh mRNA levels, which were diminished by dominant‐negative MEK1, p38α or p38β. Stimulation of the PTH1R with 10−8 M rPTH (1–34) resulted in dephosphorylation of ERK1/2 that was evident within 15 min and sustained for 1 h, as well as transient dephosphorylation of p38 MAPK that was maximal after 25 min. PTH stimulation decreased Ihh mRNA levels, and this effect was blocked by transfecting the cells with constitutively active MEK1 but not by MKK3. These studies demonstrated that activation of ERK1/2 or p38 MAPK increased Ihh mRNA levels. Stimulation of the PTH1R or blocking of β1‐integrin resulted in inhibition of ERK1/2 and p38 MAPK and decreased levels of Ihh mRNA. Our data demonstrate the central role of MAPK in the regulation of Ihh in CFK‐2 cells. © 2004 Wiley‐Liss, Inc.
Notice of RetractionThe empirical study of the affecting factors on disclosure of the internal control information — Based on the company governance

This paper analyzed the affecting factors, from company internal government structure to external governance system, on the disclosure of internal control information of the listed company, taken the 2009 annual report of company listed on GEM board as a sample for study. According to analysis of covariance, chow test, the conclusion indicated that the disclosure degree of internal control information has negative correlation to the state-owned shares nature of the first big shareholders and has positive correlation to the authority of the auditing office and the number of worker supervisors.
Design of a Nonlinear Anti-Windup Gain by Using a Composite Quadratic Lyapunov Function

This technical note revisits the problem of designing a static anti-windup gain for enlarging the domain of attraction of the resulting closed-loop system. By utilizing a composite quadratic Lyapunov function, which was originally proposed to study the stabilization problem for linear systems under actuator saturation, an existing LMI based design algorithm is enhanced to result in a nonlinear, possibly continuous, anti-windup gain. This nonlinear anti-windup gain enables us to obtain an estimate of the domain of attraction in the form of the convex hull of a group of ellipsoids, instead of a single ellipsoid that would result from a single Lyapunov function based design. Simulation results demonstrate the features of the proposed design the composite quadratic Lyapunov function brings about.
Optimising exercise training in prevention and treatment of diastolic heart failure (OptimEx-CLIN): rationale and design of a prospective, randomised, controlled trial

Background Heart failure with preserved left ventricular ejection fraction (HFpEF) currently affects more than seven million Europeans and is the only cardiovascular disease increasing in prevalence and incidence. No pharmacological agent has yet been shown to improve symptoms or prognosis. The most promising way to improve pathophysiology and deprived exercise-tolerance in HFpEF patients seems to be exercise training, but the optimal approach and dose of exercise is still unknown. Objectives The major objective of the optimising exercise training in prevention and treatment of diastolic heart failure study (OptimEx-CLIN) is to define the optimal dose of exercise training in patients with HFpEF. In order to optimise adherence, supervision and economic aspects of exercise training a novel telemedical approach will be introduced and investigated. Study design In a prospective randomised multi-centre study, 180 patients with stable symptomatic HFpEF will be randomised (1:1:1) to moderate intensity continuous training, high intensity interval training, or a control group. The training intervention includes three months supervised followed by nine months of telemedically monitored home-based training. The primary endpoint is change in exercise capacity, defined as change in peak oxygen uptake (VO2peak) after three months, assessed by cardiopulmonary exercise testing. Secondary endpoints include diastolic filling pressure (E/e′) and further echocardiographic and cardiopulmonary exercise testing (CPX) parameters, biomarkers, quality of life and endothelial function. Training sessions and physical activity will be monitored and documented throughout the study with accelerometers and heart rate monitors developed on a telemedical platform for the OptimEx-CLIN study. Inclusion of patients started in July 2014, first results are expected in 2017.
Simultaneous relaxation estimation and image reconstruction in MPI

Blurring of the images due to the relaxation effects of the magnetic nanoparticles is one of the important issues in Magnetic Particle Imaging (MPI)[1-4]. In x-space reconstructed images, relaxation blurs the image along the scanning direction, and deteriorates both the resolution and the signal-to-noise ratio (SNR) of the image[5]. Hence, removing the effects of relaxation without distorting the underlying image is crucial for increasing the efficiency of the MPI technique. Theoretically, relaxation is modelled as an exponential function r(t) = (1/τ)exp(-t/τ)u(t) using the first-order Debye process, where r(t) is then convolved with the adiabatic MPI signal[5]. Previous studies have looked into estimating the relaxation time constant, τ, using a calibration scan on a point source or using an MPI relaxometer setup[5]. In theory, if one can estimate the relaxation time constant, a deconvolution technique could be employed to obtain the underlying adiabatic MPI signal, which would yield an image unaffected by the relaxation blur. In this work, we propose a solution for blind estimation of τ directly from the MPI signal, without using a calibration scan and without the knowledge of the Langevin response of the nanoparticles.
Fatty acid amide hydrolase controls mouse intestinal motility in vivo.

BACKGROUND & AIMS Fatty acid amide hydrolase (FAAH) catalyzes the hydrolysis both of the endocannabinoids (which are known to inhibit intestinal motility) and other bioactive amides (palmitoylethanolamide, oleamide, and oleoylethanolamide), which might affect intestinal motility. The physiologic role of FAAH in the gut is largely unexplored. In the present study, we evaluated the possible role of FAAH in regulating intestinal motility in mice in vivo. METHODS Motility was measured by evaluating the distribution of a fluorescent marker along the small intestine; FAAH messenger RNA (mRNA) levels were analyzed by reverse-transcription polymerase chain reaction (RT-PCR); endocannabinoid levels were measured by isotope-dilution, liquid chromatography, mass spectrometry. RESULTS Motility was inhibited by N-arachidonoylserotonin (AA-5-HT) and palmitoylisopropylamide, 2 selective FAAH inhibitors, as well as by the FAAH substrates palmitoylethanolamide, oleamide, and oleoylethanolamide. The effect of AA-5-HT was reduced by the CB1 receptor antagonist rimonabant and by CB1 deficiency in mice but not by the vanilloid receptor antagonist 5'-iodoresiniferatoxin. In FAAH-deficient mice, pharmacologic blockade of FAAH did not affect intestinal motility. FAAH mRNA was detected in different regions of the intestinal tract. CONCLUSIONS We conclude that FAAH is a physiologic regulator of intestinal motility and a potential target for the development of drugs capable of reducing intestinal motility.
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 421 Winter Fatigue and Winter Depression Prevalence and Treatment with Bright Light

s 228:162. Florida, USA; 1998. 40. Kjellman B. The photoperiod. In: Partonen T, Magnusson A, eds. Seasonal Affective Disorder, practice and research. Oxford: Oxford University Press; 2001:163-168. 41. Young MA, Meaden PM, Fogg LF, Cherin EA, Eastman CI. Which environmental variables are related to the onset of seasonal affective disorder? J Abnorm Psychol. 1997;106(4):554-62. 42. Lam RW, Levitan RD. Pathophysiology of seasonal affective disorder: a review. J Psychiatry Neurosci. 2000;25(5):469-80. 43. Sohn CH, Lam RW. Update on the biology of seasonal affective disorder. CNS Spectr. 2005;10(8):635-46; quiz 1-14. 44. Lewy AJ, Wehr TA, Goodwin FK, Newsome DA, Markey SP. Light suppresses melatonin secretion in humans. Science. 1980;210(4475):1267-9. 45. Brainard GC, Rollag MD, Hanifin JP. Photic regulation of melatonin in humans: ocular and neural signal transduction. J Biol Rhythms. 1997;12(6):537-46. 46. Wetterberg L, ed. Light and biological rhythms in man. Oxford: Pergamon Press Ltd; 1993. 47. Molin J, Mellerup E, Bolwig T, Scheike T, Dam H. The influence of climate on development of winter depression. J Affect Disord. 1996;37(2-3):151-5. 48. Reiter RJ. The mammalian pineal gland as an end organ of the visual system. In: Wetterberg L, ed. Light and biological rhythms in man. Oxford: Pergamon Press Ltd; 1993:145-160. 49. Lewy AJ, Lefler BJ, Emens JS, Bauer VK. The circadian basis of winter depression. Proc Natl Acad Sci U S A. 2006;103(19):7414-9.
A secret sharing scheme based on the Closest Vector Theorem and a modification to a private key cryptosystem

Abstract. We explain and perform the steps for an (n,t) secret sharing scheme based on the closest vector theorem. We then compare this scheme and its complexity to the secret sharing schemes of both Shamir and Panagopoulos. Finally we modify the (n,t) secret sharing scheme to a private key cryptosystem.
S-glutathionylation of ion channels: insights into the regulation of channel functions, thiol modification crosstalk, and mechanosensing.

SIGNIFICANCE Ion channels control membrane potential, cellular excitability, and Ca(++) signaling, all of which play essential roles in cellular functions. The regulation of ion channels enables cells to respond to changing environments, and post-translational modification (PTM) is one major regulation mechanism. RECENT ADVANCES Many PTMs (e.g., S-glutathionylation, S-nitrosylation, S-palmitoylation, S-sulfhydration, etc.) targeting the thiol group of cysteine residues have emerged to be essential for ion channels regulation under physiological and pathological conditions. CRITICAL ISSUES Under oxidative stress, S-glutathionylation could be a critical PTM that regulates many molecules. In this review, we discuss S-glutathionylation-mediated structural and functional changes of ion channels. Criteria for testing S-glutathionylation, methods and reagents used in ion channel S-glutathionylation studies, and thiol modification crosstalk, are also covered. Mechanotransduction, and S-glutathionylation of the mechanosensitive KATP channel, are discussed. FUTURE DIRECTIONS Further investigation of the ion channel S-glutathionylation, especially the physiological significance of S-glutathionylation and thiol modification crosstalk, could lead to a better understanding of the thiol modifications in general and the ramifications of such modifications on cellular functions and related diseases.
Echocardiographic assessment of left ventricular function in Duchenne's muscular dystrophy.

suMMARY Left ventricular function was assessed echocardiographically in 13 children with Duchenne's muscular dystrophy. Ejection fraction, mean velocity of circumferential fibre shortening, normalised left ventricular posterior wall velocity, maximal systolic endocardial velocity, and maximal diastolic endocardial velocity were determined manually by measuring.directly from the echocardiographic tracings. The echocardiograms were then digitised and results computed in order to study the peak rates ofchange of dimension, the peak lengthening rates, the peak shortening rates, and the time relation between the mitral valve and left ventricular posterior wall movement in early diastole. All the systolic phase indices were within normal limits. Though maximal diastolic endocardial velocity (11.1 ± 3 2 cm/s = mean ± SD) was reduced in patients with Duchenne's muscular dystrophy compared with normal controls (15.3 3-2 cm/s), the peak rates of change of dimension and the peak lengthening rates were identical with normal subjects. The time relation between the mitral valve and left ventricular posterior wall movement was not significantly different from normal. The maintenance of this close time relation and the fact that the ventricle is filling normally, as evidenced by normal peak filling rates, suggest that the myocardial function is well preserved in children with Duchenne's muscular dystrophy. The reduced maximal diastolic endocardial velocity may be the result of reduced overall movement of the heart within the thorax.
Nonsurgical Direct Delivery of Plasmid DNA Into Rat Heart: Time Course, Dose Response, and the Influence of Different Promoters on Gene Expression

Transfer of genes encoding therapeutic proteins into the myocardium shows great potential for treatment of coronary artery disease. To quantitatively elucidate the behavior of plasmid DNA following cardiac gene transfer, time kinetics, dose-response relationship, systemic spread to the liver, and the influence of different promoters on plasmid DNA gene expression in rat hearts were examined using a novel nonsurgical direct delivery method that enables testing of large numbers of animals. Plasmids encoding either vascular endothelial growth factor A 165 or a fusion protein between enhanced green fluorescent protein (EGFP) luciferase were injected directly in rat hearts under echocardiographic guidance. The results show that gene expression is dose related and that the duration of gene expression is transient. These findings underscore the necessity to explore other efficient vectors or alternative methods of gene delivery to achieve increased and prolonged gene expression.
Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia*

Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes esterification of cellular cholesterol. To investigate the role of ACAT-1 in atherosclerosis, we have generated ACAT-1 null (ACAT-1−/−) mice. ACAT activities were present in the liver and intestine but were completely absent in adrenal, testes, ovaries, and peritoneal macrophages in our ACAT-1−/− mice. The ACAT-1−/− mice had decreased openings of the eyes because of atrophy of the meibomian glands, a modified form of sebaceous glands normally expressing high ACAT activities. This phenotype is similar to dry eye syndrome in humans. To determine the role of ACAT-1 in atherogenesis, we crossed the ACAT-1−/− mice with mice lacking apolipoprotein (apo) E or the low density lipoprotein receptor (LDLR), hyperlipidemic models susceptible to atherosclerosis. High fat feeding resulted in extensive cutaneous xanthomatosis with loss of hair in both ACAT-1−/−:apo E−/− and ACAT-1−/−:LDLR−/− mice. Free cholesterol content was significantly increased in their skin. Aortic fatty streak lesion size as well as cholesteryl ester content were moderately reduced in both double mutant mice compared with their respective controls. These results indicate that the local inhibition of ACAT activity in tissue macrophages is protective against cholesteryl ester accumulation but causes cutaneous xanthomatosis in mice that lack apo E or LDLR.
LEVEL SPACINGS DISTRIBUTION We have to examine two aspects of the proof of Theorem

We study the level-spacings distribution for eigenvalues of large N X N matrices from the classical compact groups in the scaling limit when the mean distance between nearest eigenvalues equals 1. Defining by 77N(S) the number of nearest neighbors spacings greater than s > 0 (smaller than s > 0) we prove functional limit theorem for the process (77N(S)-E%/N(S))/N1/2, giving weak convergence of this distribution to some Gaussian random process on [0, x). The limiting Gaussian random process is universal for all classical compact groups. It is Holder continuous with any exponent less than 1/2. Similar results can be obtained for the n-level-spacings distribution.
Hereditary ceruloplasmin deficiency with hemosiderosis: A clinicopathological study of a japanese family

A hereditary ceruloplasmin deficiency associated with severe iron deposition in visceral organ and brain tissues found on histopathological examination at autopsy is discussed. Three siblings of consanguineous Japanese parents were studied. Their clinical symptoms were progressive dementia, extrapyramidal disorders, cerebellar ataxia, and diabetes mellitus, all of which appeared when they were between 30 and 50 years old. All had serum ceruloplasmin deficiencies and increased serum ferritin concentrations. The dentate nucleus, thalamus, putamen, caudate nucleus, and liver of each one showed low signal intensities on T1‐ and T2‐weighted magnetic resonance images. Examination of the central nervous system revealed severe destruction of the basal ganglia and dentate nucleus, with considerable iron deposition in neuronal and glial cells, whereas the cerebral cortex showed mild iron deposition in glial cells without neuronal involvement. An electron microscopic study with energy‐dispersive x‐ray analysis showed iron depositions in the hepatocytes, of both the neural and glial cells of the brain. We consider this a new disease entity because of the primary ceruloplasmin deficiency.