Miracle-dz/UniFAR-FTUs huggingface dataset:
On the Recording Reference Contribution to EEG Correlation, Phase Synchorony, and Coherence

The degree of synchronization in electroencephalography (EEG) signals is commonly characterized by the time-series measures, namely, correlation, phase synchrony, and magnitude squared coherence (MSC). However, it is now well established that the interpretation of the results from these measures are confounded by the recording reference signal and that this problem is not mitigated by the use of other EEG montages, such as bipolar and average reference. In this paper, we analyze the impact of reference signal amplitude and power on EEG signal correlation, phase synchrony, and MSC. We show that, first, when two nonreferential signals have negative correlation, the phase synchrony and the absolute value of the correlation of the two referential signals may have two regions of behavior characterized by a monotonic decrease to zero and then a monotonic increase to one as the amplitude of the reference signal varies in [0, +∞). It is notable that even a small change of the amplitude may lead to significant impact on these two measures. Second, when two nonreferential signals have positive correlation, the correlation and phase-synchrony values of the two referential signals can monotonically increase to one (or monotonically decrease to some positive value and then monotonically increase to one) as the amplitude of the reference signal varies in [0, + ∞). Third, when two nonreferential signals have negative cross-power, the MSC of the two referential signals can monotonically decrease to zero and then monotonically increase to one as reference signal power varies in [0, + ∞). Fourth, when two nonreferential signals have positive cross-power, the MSC of the two referential signals can monotonically increase to one as the reference signal power varies in [0, + ∞). In general, the reference signal with small amplitude or power relative to the signals of interest may decrease or increase the values of correlation, phase synchrony, and MSC. However, the reference signal with high relative amplitude or power will always increase each of the three measures. In our previous paper, we developed a method to identify and extract the reference signal contribution to intracranial EEG (iEEG) recordings. In this paper, we apply this approach to referential iEEG recorded from human subjects and directly investigate the contribution of recording reference on correlation, phase synchrony, and MSC. The experimental results demonstrate the significant impact that the recording reference may have on these bivariate measures.
Mid-term Results of Intramuscular Lengthening of Gastrocnemius and/or Soleus to Correct Equinus Deformity in Flatfoot

Background: Intramuscular lengthening of the gastrocnemius and/or soleus (Baumann procedure) is widely used in patients who have cerebral palsy, with several advantages over other lengthening techniques. Tightness of the gastrocnemius or gastrocnemius-soleus complex has been confirmed to be related to flatfoot deformity. The purpose of this study was to evaluate the mid-term results of the Baumann procedure as a part of the treatment of flatfoot with equinus deformity. Methods: We reviewed 35 pediatric and adult patients (43 feet) with flatfoot who underwent the Baumann procedure for the concomitant equinus deformity. The mean duration of follow-up was 39.4 months. Preoperative and follow-up evaluations included the maximal angle of dorsiflexion of the ankle with the knee fully extended and with the knee flexed to 90 degrees, the American Orthopaedic Foot & Ankle Society ankle-hindfoot (AOFAS-AH) scores, and postoperative complications. Results: Preoperatively, the mean angle of passive ankle dorsiflexion with the knee extended was −4.7 ± 2.7 degrees and that with the knee flexed was 2.3 ± 2.5 degrees. At the final follow-up, both values improved significantly by a mean of 13.6 degrees (P < .001) and 9.7 degrees (P < .001), respectively. The average AOFAS-AH scores improved from 56.8 points preoperatively to 72.1 at the final follow-up. Recurrence of equinus was observed in 3 patients (4 feet). There were no cases of overcorrection, neurovascular injury, or healing problems. Conclusions: Our results indicate that the Baumann procedure can effectively and sequentially correct the tightness of the gastrocnemius or the gastrocnemius-soleus complex in patients with flatfoot deformity, without obvious postoperative complications. Level of Evidence: Level IV, retrospective case series.
Concurrency control in real-time broadcast environments q

Owing to the unique characteristics of real-time broadcast environments, serializability is too strong as a correctness criterion and not suitable for mobile real-time transactions. Considering that relaxing serializability such as epsilon and similarity serializability may sacrifice database consistency to some extent, we propose using a correctness criterion called weak serializability. In this paper, we formally define weak serializability at first. After the necessary and sufficient conditions for weak serializability are shown, corresponding concurrency control protocol based on this criterion is outlined for real-time broadcast environments. Finally, in a series of simulation studies, experimental results show that the proposed protocol helps more mobile real-time transactions to meet their deadlines and improves response time while database consistency is maintained. 2002 Elsevier Inc. All rights reserved.
The relation between children’s constructive play activities, spatial ability, and mathematical word problem-solving performance: a mediation analysis in sixth-grade students

The scientific literature shows that constructive play activities are positively related to children’s spatial ability. Likewise, a close positive relation is found between spatial ability and mathematical word problem-solving performances. The relation between children’s constructive play and their performance on mathematical word problems is, however, not reported yet. The aim of the present study was to investigate whether spatial ability acted as a mediator in the relation between constructive play and mathematical word problem-solving performance in 128 sixth-grade elementary school children. This mediating role of spatial ability was tested by utilizing the current mediation approaches suggested by Preacher and Hayes (2008). Results showed that 38.16% of the variance in mathematical word problem-solving performance is explained by children’s constructive play activities and spatial ability. More specifically, spatial ability acted as a partial mediator, explaining 31.58% of the relation between constructive play and mathematical word problem-solving performance.
Comprehension problems in children with specific language impairment: does mental imagery training help?

BACKGROUND Children with specific language impairment experience story comprehension deficits. Research with typically developing children, poor comprehenders and poor readers has shown that the use of mental imagery aids in the comprehension of stories. AIMS To evaluate the effectiveness of an intervention programme in the use of mental imagery to improve the literal and inferential comprehension of children with specific language impairment. METHODS & PROCEDURES Nine children with specific language impairment were trained to produce mental images for sentences and stories in five 30-min sessions. Their ability to answer literal and inferential questions about short narratives was assessed pre- and post-intervention and compared with the performance of 16 same-age typically developing controls. OUTCOME & RESULTS The intervention improved the question-answering performance of the children with specific language impairment for both literal and inferential questions: the improvement was only significant for the literal questions. CONCLUSIONS The findings demonstrate that a relatively short intervention in the use of mental imagery is an effective way to boost the story comprehension of children with specific language impairment.
Flux vacua attractors and generalized compactifications

We investigate whether there are attractor equations for N = 1 flux vacua in generalized compactifications. We fill a gap in the existing literature by verifying analytically that the recently proposed susy attractors, for type IIB CY(3) orientifold compactifications with flux, do give supersymmetric minima of the relevant scalar potential. Furthermore, our considerations clarify various confusions about existing proposals for generalization of the flux vacua attractors to non-Kahler compactifications. We explore different possibilities for generalization and find attractor equations for N = 1 Minkowski vacua only both for the heterotic string on SU(3) structure manifolds and for type IIA/B on SU(3) × SU(3) structure spaces
Micropatterned surfaces for reducing the risk of catheter-associated urinary tract infection: an in vitro study on the effect of sharklet micropatterned surfaces to inhibit bacterial colonization and migration of uropathogenic Escherichia coli.

BACKGROUND AND PURPOSE Catheter-associated urinary tract infection (CAUTI) is the most common device-associated infection and can result in serious medical consequences. We studied the efficacy of a novel microscopic physical surface modification (Sharklet) for preventing bacterial colonization and migration of uropathogenic Escherichia coli on silicone elastomer. MATERIALS AND METHODS In vitro growth assays evaluated E coli colonization using three variations of micropatterned silicone surfaces vs a smooth silicone control. Enumeration techniques included quantification of colonies on surfaces and analysis of bacterial area coverage and colony size. In vitro migration assays involved placement of micropatterned and smooth silicone rod segments between two agar islands to measure incidence of migration. RESULTS All three variations of the Sharklet micropattern outperformed the control surfaces in inhibiting E coli colonization. On average, 47% reduction in colony-forming units (CFUs) and bacterial area coverage plus 77% reduction in colony size were achieved with the Sharklet surfaces in tryptic soy broth and artificial urine compared with the control nonpatterned surfaces. The incidence of E coli migration over the rod segments was reduced by more than 80% for the Sharklet transverse patterned rods compared with the unpatterned control rods. CONCLUSION The Sharklet micropattern is effective at inhibiting colonization and migration of a common uropathogen. This performance is achieved through a physical surface modification without the use of any antimicrobial agents. Because deterrence of bacterial colonization and migration is a critical step to prevent CAUTI, the Sharklet micropattern offers a novel concept in addressing this important problem.
Towards Computer-Aided Diagnostics of Screening Mammography Using Content-Based Image Retrieval

Screening mammography has been established worldwide for early detection of breast cancer, one of the main causes of death among women in occidental countries. In this paper, we aim at moving towards computer-aided diagnostics of screening mammography. Tissue and lesion are classified using the methodology of content-based image retrieval. In addition, we aim at comprehensive evaluation and have established a large database of annotated reference images (ground truth), which has been merged and unified from different sources publicly available to research. In total, 10,509 mammographic images have been collected from the different sources. From this, 3,375 images are provided with one and 430 radiographs with more than one chain code annotations. This data supports experiments with up to 12 classes, and 233 images per class if a equal distribution is required. Using a two-dimensional principal component analysis with four eigenvalues and a support vector machine with Gaussian kernel for feature extraction and image retrieval, respectively, the precision of computer-aided diagnosis is above 80%. It therefore may be used as second opinion in screening mammography.
Foot-and-Mouth Disease Virus Exhibits an Altered Tropism in the Presence of Specific Immunoglobulins, Enabling Productive Infection and Killing of Dendritic Cells

ABSTRACT Foot-and-mouth disease virus (FMDV) causes an acute vesicular disease of farm animals. The development of successful control strategies is limited by an incomplete understanding of the immune response to FMDV. Dendritic cells (DC) mediate the induction of immunity to pathogens, but their role in FMDV infection of cattle is uncharacterized. Bovine monocyte-derived DC (moDC) were exposed to integrin-binding and cell culture-adapted strains of FMDV in vitro. MoDC were not largely susceptible to infection by integrin-binding FMDV but were susceptible to culture-adapted virus. Binding specific antibodies to integrin-binding FMDV at neutralizing or subneutralizing IgG concentrations significantly enhanced infection via CD32 (FcγR). Monocytes also expressed CD32 but were nonsusceptible to FMDV immune complex (IC) infection, indicating a requirement for additional factors involved in cellular susceptibility. Infection of moDC by the FMDV IC was productive and associated with high levels of cell death. Infected moDC were unable to efficiently stimulate FMDV-specific CD4+ memory T cells, but exposing moDC to IC containing inactivated FMDV resulted in significantly increased T cell stimulation. Thus, neutralized FMDV concurrently loses its ability to infect susceptible cells while gaining the capacity to infect immune cells. This represents a change in the tropism of FMDV that could occur after the onset of the antibody response. We propose that IC could dynamically influence the anti-FMDV immune response and that this may explain why the early immune response to FMDV has evolved toward T cell independence in vivo. Moreover, we propose that DC targeting could prove useful in the development of effective vaccines against FMDV.
Soft output multiuser detection via a Markov chain Monte Carlo approach

This paper investigates the use of computational Bayesian methods for multiuser detection (MUD) of synchronous direct-sequence code-division multiple access (DS-CDMA) systems. The Markov chain Monte Carlo (MCMC) multiuser detection methods proposed in this paper are iterative, and offer near-optimal performance with manageable complexity even at high system loads. Moreover, posterior symbol probabilities produced by the detector are suitable for use as prior probabilities for soft-input channel decoders
Non-abelian 4-d black holes, wrapped 5-branes, and their dual descriptions

We study extremal and non-extremal generalizations of the regular non-abelian monopole solution of [23], interpreted in [9] as 5-branes wrapped on a shrinking S-2. Naively, the low energy dynamics is pure N = 1 supersymmetric Yang-Mills. However, our results suggest that the scale of confinement and chiral symmetry breaking in the Yang-Mills theory actually coincides with the Hagedorn temperature of the little string theory. We find solutions with regular horizons and arbitrarily high Hawking temperature. Chiral symmetry is restored at high energy density, corresponding to large black holes. But the entropy of the black hole solutions decreases as one proceeds to higher temperatures, indicating that there is a thermodynamic instability and that the canonical ensemble is ill-defined. For certain limits of the black hole solutions, we exhibit explicit non-linear sigma models involving a linear dilaton. In other limits we find extremal non-BPS solutions which may have some relevance to string cosmology.
Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1

Interferon stimulation of cells leads to the tyrosine phosphorylation of latent Stat1 and subsequent transient accumulation in the nucleus that requires canonical transport factors. However, the mechanisms that control the predominantly cytoplasmic localization in unstimulated cells have not been resolved. We uncovered that constitutive energy- and transport factor-independent nucleocytoplasmic shuttling is a property of unphosphorylated Stat1, Stat3, and Stat5. The NH2- and COOH-terminal Stat domains are generally dispensable, whereas alkylation of a single cysteine residue blocked cytokine-independent nuclear translocation and thus implicated the linker domain into the cycling of Stat1. It is revealed that constitutive nucleocytoplasmic shuttling of Stat1 is mediated by direct interactions with the FG repeat regions of nucleoporin 153 and nucleoporin 214 of the nuclear pore. Concurrent active nuclear export by CRM1 created a nucleocytoplasmic Stat1 concentration gradient that is significantly reduced by the blocking of energy-requiring translocation mechanisms or the specific inactivation of CRM1. Thus, we propose that two independent translocation pathways cooperate to determine the steady-state distribution of Stat1.
A feed-forward approach for DC cancellation in fully-differential instrumentation amplifiers

DC suppression consists of a mandatory procedure in several measurement applications. In many situations, its value is orders of magnitude above the desired information to be measured. In fully-differential instrumentation amplifiers, which present a very high common-mode rejection ratio, matched coupling capacitors are demanded for CMRR not to degrade. Stability problems can arise if active cancellation is employed. This paper presents a fully-differential instrumentation amplifier with DC suppression that employs a feed-forward scheme. A mathematical analysis of the proposed circuit is conducted in order to predict its behavior, followed by simulations and experimental measurements for analysis and validation. An excelent performance is achieved, even with standard precision components.
The lung cancer database project at the National Cancer Center, Japan: study design, corresponding rate and profiles of cohort.

BACKGROUND The lung cancer database project was established in 1999 at the National Cancer Center Hospital East, Japan, as an ongoing project to integrate data on various factors in lung cancer patients. The aim of the project was to construct a large-scale cancer registry for lung cancer that would contribute to basic research and clinical research in the future. METHODS Between July 1999 and July 2004, consecutive lung cancer patients were recruited into this project. The baseline survey consisted of self-administered questionnaires concerning various demographic data, health habits and psychological factors. Medical information was obtained from the patients' medical charts. Urine specimens and blood samples were collected, and DNA was extracted from blood lymphocytes. RESULTS Out of the 2506 patients who were asked to participate in the project, 2036 (81%) patients with newly diagnosed, untreated primary lung cancer were enrolled. The final analytic cohort consisted of 1995 patients. Virtually all of the 1995 patients (corresponding rate, 99%) completed the questionnaires on demographic data and health habits. The corresponding rates for the questionnaires on psychological factors and dietary habits were 99 and 94%, respectively. In a follow-up survey conducted to determine vital status as of December 2004, a total of 1051 patients (53%) had died and 44 patients (2%) were lost to follow-up. CONCLUSIONS This paper overviews the rationale for initiating the lung cancer database project, Japan. This database should prove useful for researchers examining the pathogenesis of lung cancer and may contribute to the formulation of a framework for cancer treatment.
Phenolic Composition, Anti‐Inflammatory, Antioxidant, and Antimicrobial Activities of Alchemilla mollis (Buser) Rothm.

The current study was designed to evaluate the antioxidant, anti‐inflammatory and antimicrobial activities of Alchemilla mollis (Buser) Rothm. (Rosaceae) aerial parts extracts. Chemical composition was analyzed by spectrophotometric and chromatographic (HPLC) techniques. The antioxidant properties assessed included DPPH· and ABTS·+ radical scavenging, β‐carotene‐linoleic acid co‐oxidation assay. Antimicrobial activity was evaluated with disc diffusion and micro dilution method. In order to evaluate toxicity of the extracts, with the sulforhodamine B colorimetric assay L929 cell line (mouse fibroblast) was used. The anti‐inflammatory activities of the potent antioxidant extracts (methanol, 70% methanol, and water extracts) were determined by measuring the inhibitory effects on NO production and pro‐inflammatory cytokine TNF‐α levels in lipopolysaccharide stimulated RAW 264.7 cells. 70% methanol and water extracts which were found to be rich in phenolic compounds (184.79 and 172.60 mg GAE/g extract) showed higher antioxidant activity. Luteolin‐7‐O‐glucoside was the main compound in the extracts. Ethyl acetate and 70% methanol extracts showed higher antibacterial activity against Staphylococcus aureus and Salmonella enteritidis with MIC value of 125 μg/ml. 70% methanol extract potentially inhibited the NO and TNF‐α production (18.43 μm and 1556.22 pg/ml, respectively, 6 h).
Meis1 regulates Foxn4 expression during retinal progenitor cell differentiation

Summary The transcription factor forkhead box N4 (Foxn4) is a key regulator in a variety of biological processes during development. In particular, Foxn4 plays an essential role in the genesis of horizontal and amacrine neurons from neural progenitors in the vertebrate retina. Although the functions of Foxn4 have been well established, the transcriptional regulation of Foxn4 expression during progenitor cell differentiation remains unclear. Here, we report that an evolutionarily conserved 129 bp noncoding DNA fragment (Foxn4CR4.2 or CR4.2), located ∼26 kb upstream of Foxn4 transcription start site, functions as a cis-element for Foxn4 regulation. CR4.2 directs gene expression in Foxn4-positive cells, primarily in progenitors, differentiating horizontal and amacrine cells. We further determined that the gene regulatory activity of CR4.2 is modulated by Meis1 binding motif, which is bound and activated by Meis1 transcription factor. Deletion of the Meis1 binding motif or knockdown of Meis1 expression abolishes the gene regulatory activity of CR4.2. In addition, knockdown of Meis1 expression diminishes the endogenous Foxn4 expression and affects cell lineage development. Together, we demonstrate that CR4.2 and its interacting Meis1 transcription factor play important roles in regulating Foxn4 expression during early retinogenesis. These findings provide new insights into molecular mechanisms that govern gene regulation in retinal progenitors and specific cell lineage development.
Area-Feature Boundary Labeling

Boundary labeling is a relatively new labeling method. It can be useful in automating the production of technical drawings and medical drawings, where it is common to explain certain parts of the drawing with text labels, arranged on its boundary so that other parts of the drawing are not obscured. In boundary labeling, we are given a rectangle R which encloses a set of n sites. Each site s is associated with an axis-parallel rectangular label ls. The labels must be placed in distinct positions on the boundary of R and they must be connected to their corresponding sites with polygonal lines, called leaders, so that the labels are pairwise disjoint and the leaders do not intersect each other. In this paper, we study a version of the boundary labeling problem where the sites can ‘float’ within a polygonal region. We present a polynomial time algorithm, which runs in O(n3) time and produces a labeling of minimum total leader length for labels of uniform size placed in fixed positions on the boundary of rectangle R.