Miracle-dz/UniFAR-FTUs huggingface dataset:
Chemoradiotherapy Combined With Intracavitary Hyperthermia for Anal Cancer: Feasibility and Long-Term Results From a Phase II Randomized Trial

Purpose:The purpose of this study was to investigate in a randomized way the clinical benefit of addition of intracavitary hyperthermia (ICHT) to a conventional chemoradiotherapy schedule in patients with T2-T3N0M0 anal cancer. Methods and Materials:Patients were randomly assigned to undergo chemotherapy with 5-fluorouracil (5-FU) and mitomycin-C combined with radiotherapy with (arm A: 24 patients) or without ICHT (arm B: 25 patients). A microwave applicator operating at 433 MHz inserted into the anal–rectal cavity was used for ICHT. Patients in both arms received 1000 mg/m2 per day of 5-FU on days 1–4 and days 28–31 plus 15 mg/m2 mitomycin-C on day 1. Radiotherapy was administered with a dose of 41.4 Gy (1.8 Gy per fraction) plus a booster dose of 14 Gy (2 Gy per fraction). Results:One patient from group A developed severe mucositis, whereas no severe morbidity was noted in the rest of the patients in both groups. The incidence of lower-intestine acute reactions was higher in the ICHT arm. After a 5-year follow up in the hyperthermia arm, 23 of 24 patients (95.8%) preserved their anorectal function and avoided permanent colostomy, whereas in the second arm, 17 of 25 (68.0%) had sphincter preservation. Local recurrence-free survival time was significantly higher in the ICHT arm (P = 0.0107, log rank test), whereas no significant difference in overall survival was noted. Conclusion:The addition of ICHT to the chemoradiotherapy schedule of anal cancer seems to offer a new effective and safe therapeutic modality. The preservation of anorectal function seems to be the significant clinical benefit of adjuvant ICHT.
Brownian motion near a partial-slip boundary: A local probe of the no-slip condition

Motivated by experimental evidence of violations of the no-slip boundary condition for liquid flow in micrometer-scale geometries, we propose a simple, complementary experimental technique that has certain advantages over previous studies. Instead of relying on externally induced flow or probe motion, we suggest that colloidal diffusivity near solid surfaces contains signatures of the degree of fluid slip exhibited on those surfaces. To investigate, we calculate the image system for point forces Stokeslets oriented perpendicular and parallel to a surface with a finite slip length, analogous to Blake’s solution for a Stokeslet near a no-slip wall. Notably, the image system for the point source and perpendicular Stokeslet contain the same singularities as Blake’s solution; however, each is distributed along a line with a magnitude that decays exponentially over the slip length. The image system for the parallel Stokeslet involves a larger set of fundamental singularities, whose magnitude does not decay exponentially from the surface. Using these image systems, we determine the wall-induced correction to the diffusivity of a small spherical particle located “far” from the wall. We also calculate the coupled diffusivities between multiple particles near a partially slipping wall. Because, in general, the diffusivity depends on “local” wall conditions, patterned surfaces would allow differential measurements to be obtained within a single experimental cell, eliminating potential cell-to-cell variability encountered in previous experiments. In addition to motivating the proposed experiments, our solutions for point forces and sources near a partial-slip wall will be useful for boundary integral calculations in slip systems. © 2005 American Institute of Physics. DOI: 10.1063/1.2083748
ARTEMIS @ MediaEval 2013: A Content-Based Image Clustering Method for Public Image Repositories

In this paper, we describe our approach and its results as part of the MediaEval 2013 Retrieving Diverse Social Images Task evaluation. We illustrate a content - based technique relying on a single type of visual descriptors that makes it possible to identify groups of similar instances of a given landmark and select the most representative images from each such group out of a set of relatively noisy or redundant images. This method builds for each landmark a matching graph through quantized interest points similarities and identifies groups of similar instances of the landmark as connected components. In this approach we do not make use of the textual metadata of the images or any other external source of information.
Coordinated Morphogenetic Mechanisms Shape the Vertebrate Eye

The molecular bases of vertebrate eye formation have been extensively investigated during the past 20 years. This has resulted in the definition of the backbone of the gene regulatory networks controlling the different steps of eye development and has further highlighted a substantial conservation of these networks among vertebrates. Yet, the precise morphogenetic events allowing the formation of the optic cup from a small group of cells within the anterior neural plate are still poorly understood. It is also unclear if the morphogenetic events leading to eyes of very similar shape are indeed comparable among all vertebrates or if there are any species-specific peculiarities. Improved imaging techniques have enabled to follow how the eye forms in living embryos of a few vertebrate models, whereas the development of organoid cultures has provided fascinating tools to recapitulate tissue morphogenesis of other less accessible species. Here, we will discuss what these advances have taught us about eye morphogenesis, underscoring possible similarities and differences among vertebrates. We will also discuss the contribution of cell shape changes to this process and how morphogenetic and patterning mechanisms integrate to assemble the final architecture of the eye.
Delivering Energy Proportionality with Non Energy-Proportional Systems - Optimizing the Ensemble

With power having become a critical issue in the operation of data centers today, there has been an increased push towards the vision of "energy-proportional computing", in which no power is used by idle systems, very low power is used by lightly loaded systems, and proportionately higher power at higher loads. Unfortunately, given the state of the art of today's hardware, designing individual servers that exhibit this property remains an open challenge. However, even in the absence of redesigned hardware, we demonstrate how optimization-based techniques can be used to build systems with off-the-shelf hardware that, when viewed at the aggregate level, approximate the behavior of energy-proportional systems. This paper explores the viability and tradeoffs of optimization-based approaches using two different case studies. First, we show how different power-saving mechanisms can be combined to deliver an aggregate system that is proportional in its use of server power. Second, we show early results on delivering a proportional cooling system for these servers. When compared to the power consumed at 100% utilization, results from our testbed show that optimization-based systems can reduce the power consumed at 0% utilization to 15% for server power and 32% for cooling power.
A Growth Initiation Factor for Host-Independent Derivatives of Bdellovibrio bacteriovorus

Host-independent (H-I) derivatives of Bdellovibrio bacteriovorus 109 Davis could not be isolated when concentrated suspensions of host-dependent (H-D) cultures, washed free of spent medium, were plated on host-free media. However, H-I colonies did appear when spent broth was incorporated into the isolation medium, indicating the presence of a factor in the spent medium essential for the growth of H-I cells. This growth factor (GIF) was also present in cell-free extracts of Escherichia coli and a variety of other microorganisms including H-D and H-I derivatives of strain 109 Davis. GIF was heat stable, non-dialyzable, and present in both soluble and particulate fractions of extracts. Heating of extracts at 70 C for 10 min resulted in 10- to 40-fold stimulation in GIF activity, and evidence for a heat-labile inhibitor was obtained. Colonies appearing on host-free medium in these experiments were shown to be those of typical H-I derivatives by isolation and subsequent host-independent cultivation of these organisms. GIF was a conditional requirement dependent on age and size of inoculum for all H-I derivatives characterized. Although GIF stimulated the growth of washed exponential phase cells transferred to fresh medium, it was not essential for growth. However, it was essential for the initiation of growth of washed stationary phase cells from small inocula transferred to fresh medium. It is proposed that GIF is required to initiate growth of metabolically quiescent cells.
Socioenvironmental, Personal, and Behavioral Correlates of Severe Obesity among an Ethnically/Racially Diverse Sample of US Adolescents.

BACKGROUND Severe obesity among adolescents, also known as class 2 and 3 obesity, is increasing in prevalence, yet, little is known about adolescents with severe obesity. The objective of this study was to identify the socioenvironmental, personal, and behavioral correlates of severe obesity among an ethnically/racially diverse sample of US adolescents. METHODS A cross-sectional analysis of data from participants in the EAT 2010 study (n = 2706) was conducted. Adolescents completed in-class surveys, and height and weight were measured. Severe obesity was defined as a BMI ≥120% of the 95th percentile or ≥35 kg/m2; class 1 obesity as a BMI ≥95th percentile but below severe obesity cut points, overweight as a BMI <95th percentile but ≥85th percentile, and normal weight as a BMI <85th but >5th percentile. General linear models were used to identify differences between adolescents by weight status, adjusted for covariates. RESULTS Nine percent of adolescents had severe obesity. Compared with peers of other weight statuses, a greater proportion of adolescents with severe obesity reported parental encouragement to diet and peer weight teasing. Adolescents with severe obesity also reported lower self-esteem and body satisfaction. Binge eating was three times as prevalent among adolescents with severe obesity compared with peers of normal weight and twice as prevalent as among peers with class 1 obesity. CONCLUSIONS Adolescents with severe obesity report several unique socioenvironmental, personal, and behavioral concerns that may diminish quality of life and may predict increased weight gain over time.
R2: Incremental Reprogramming Using Relocatable Code in Networked Embedded Systems

We present R2, an incremental reprogramming approach using relocatable code, to improve program similarity for efficient incremental reprogramming in networked embedded systems. R2 achieves a higher degree of similarity than existing approaches by mitigating effects of both function shifts and data shifts. R2 adopts a content-aware differencing algorithm to generate small delta files for efficient dissemination. Besides, it makes efficient use of memory and does not degrade program quality. We implement R2 based on TinyOS 2.1 and demonstrate its advantages through detailed analysis of TinyOS examples. We also present case studies on the software programs of a large-scale sensor system GreenOrbs. Results show that R2 reduces the dissemination cost by approximately 65 percent compared to state-of-the-art network reprogramming approach Deluge, and reduces the dissemination cost by approximately 20 percent compared to Zephyr and Hermes the latest works on incremental reprogramming.
A Texture-Based Local Soft Voting Method for Vanishing Point Detection from a Single Road Image

SUMMARY Estimating a proper location of vanishing point from a single road image without any prior known camera parameters is a challenging problem due to limited information from the input image. Most edge-based methods for vanishing point detection only work well for structured roads with clear painted lines or distinct boundaries, while they usually fail in unstructured roads lacking sharply defined, smoothly curving edges. In order to overcome this limitation, texture-based methods for vanishing point detection have been widely published. Authors of these methods often calculate the texture orientation at every pixel of the road image by using directional filter banks such as Gabor wavelet filter, and seek the vanishing point by a voting scheme. A local adaptive soft voting method for obtaining the vanishing point was proposed in a previous study. Although this method is more effective and faster than prior texture-based methods, the associated computational cost is still high due to a large number of scanning pixels. On the other hand, this method leads to an estimation error in some images, in which the radius of the proposed half-disk voting region is not large enough. The goal of this paper is to reduce the computational cost and improve the performance of the algorithm. Therefore, we propose a novel local soft voting method, in which the number of scanning pixels is much reduced, and a new vanishing point candidate region is introduced to improve the estimation accuracy. The proposed method has been implemented and tested on 1000 road images which contain large variations in color, texture, lighting condition and surrounding environment. The experimental results demonstrate that this new voting method is both efficient and effective in detecting the vanishing point from a single road image and requires much less computational cost when compared to the previous voting method.
Memory Concerns, Memory Performance and Risk of Dementia in Patients with Mild Cognitive Impairment

Background Concerns about worsening memory (“memory concerns”; MC) and impairment in memory performance are both predictors of Alzheimer's dementia (AD). The relationship of both in dementia prediction at the pre-dementia disease stage, however, is not well explored. Refined understanding of the contribution of both MC and memory performance in dementia prediction is crucial for defining at-risk populations. We examined the risk of incident AD by MC and memory performance in patients with mild cognitive impairment (MCI). Methods We analyzed data of 417 MCI patients from a longitudinal multicenter observational study. Patients were classified based on presence (n = 305) vs. absence (n = 112) of MC. Risk of incident AD was estimated with Cox Proportional-Hazards regression models. Results Risk of incident AD was increased by MC (HR = 2.55, 95%CI: 1.33–4.89), lower memory performance (HR = 0.63, 95%CI: 0.56–0.71) and ApoE4-genotype (HR = 1.89, 95%CI: 1.18–3.02). An interaction effect between MC and memory performance was observed. The predictive power of MC was greatest for patients with very mild memory impairment and decreased with increasing memory impairment. Conclusions Our data suggest that the power of MC as a predictor of future dementia at the MCI stage varies with the patients' level of cognitive impairment. While MC are predictive at early stage MCI, their predictive value at more advanced stages of MCI is reduced. This suggests that loss of insight related to AD may occur at the late stage of MCI.
A 40-mW 7-bit 2.2-GS/s Time-Interleaved Subranging CMOS ADC for Low-Power Gigabit Wireless Communications

A 7-bit, 2.2-GS/s time-interleaved subranging CMOS analog-to-digital converter (ADC) for low-power gigabit wireless communication system-on-a-chip (SoC) is presented. A time-splitting subranging architecture is invented to significantly boost the speed of individual ADC channels. In addition, a low-power and fast-settling distributed resistor array for reference voltages is proposed to mitigate gain mismatches within channels. Moreover, the channel offset mismatches are calibrated through the digital- controlled corrective current sources embedded in the track-and-hold amplifiers of each sub-ADC. The prototype is implemented in 65 nm CMOS, occupying only 0.3 mm2 chip area and consuming 40 mW at 2.2 GS/s from a 1 V supply. Measured signal-to-noise and distortion ratio (SNDR) and spurious-free dynamic range (SFDR) are 38 dB and 46 dB, respectively, with a 1.08 GHz input at 2.2 GS/s sampling rate. The effective number of bits (ENOB) is 6.0 bits at Nyquist rate, and the figure-of-merit (F.O.M.) is 0.28 pJ/conv. -step. This prototype has also been integrated into a gigabit self-healing wireless transceiver SoC.
Hybridization masks speciation in the evolutionary history of the Galápagos marine iguana

The effects of the direct interaction between hybridization and speciation—two major contrasting evolutionary processes—are poorly understood. We present here the evolutionary history of the Galápagos marine iguana (Amblyrhynchus cristatus) and reveal a case of incipient within-island speciation, which is paralleled by between-island hybridization. In-depth genome-wide analyses suggest that Amblyrhynchus diverged from its sister group, the Galápagos land iguanas, around 4.5 million years ago (Ma), but divergence among extant populations is exceedingly young (less than 50 000 years). Despite Amblyrhynchus appearing as a single long-branch species phylogenetically, we find strong population structure between islands, and one case of incipient speciation of sister lineages within the same island—ostensibly initiated by volcanic events. Hybridization between both lineages is exceedingly rare, yet frequent hybridization with migrants from nearby islands is evident. The contemporary snapshot provided by highly variable markers indicates that speciation events may have occurred throughout the evolutionary history of marine iguanas, though these events are not visible in the deeper phylogenetic trees. We hypothesize that the observed interplay of speciation and hybridization might be a mechanism by which local adaptations, generated by incipient speciation, can be absorbed into a common gene pool, thereby enhancing the evolutionary potential of the species as a whole.
T Cell and APC Dynamics In Situ Control the Outcome of Vaccination

The factors controlling the progression of an immune response to generation of protective memory are poorly understood. We compared the in situ and ex vivo characteristics of CD8 T cells responding to different forms of the same immunogen. Immunization with live Listeria monocytogenes, irradiated L. monocytogenes (IRL), or heat-killed L. monocytogenes (HKL) induced rapid activation of CD8 T cells. However, only IRL and live L. monocytogenes inoculation induced sustained proliferation and supported memory development. Gene and protein expression analysis revealed that the three forms of immunization led to three distinct transcriptional and translational programs. Prior to cell division, CD8 T cell–dendritic cell clusters formed in the spleen after live L. monocytogenes and IRL but not after HKL immunization. Furthermore, HKL immunization induced rapid remodeling of splenic architecture, including loss of marginal zone macrophages, which resulted in impaired bacterial clearance. These results identify initial characteristics of a protective T cell response that have implications for the development of more effective vaccination strategies.
Personalized Multi-Regression Models for Predicting Students ’ Performance in Course Activities

Methods that accurately predict the grade of a student at a given activity and/or course can identify students that are at risk in failing a course and allow their educational institution to take corrective actions. Though a number of approaches have been developed for building such performance prediction models, they either estimate a single model for all students based on their past course performance and interactions with learning management systems (LMS), or estimate student-specific models that do not take into account LMS interactions; thus, failing to exploit fine-grain information related to a student’s engagement and effort in a course. In this work we present a class of linear multi-regression models that are designed to produce models that are personalized to each student and also take into account a large number of features that relate to a student’s past performance, course characteristics, and student’s engagement and effort. These models estimate a small number of regression models that are shared across the different students along with studentspecific linear combination functions to facilitate personalization. Our experimental evaluation on a large set of students, courses, and activities shows that these models are capable of improving the performance prediction accuracy by over 20%. In addition, we show that by analyzing the estimated models along with the student-specific combination functions we can gain insights on the effectiveness of the educational material that is made available at the courses of different departments.
Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism in high-risk patients.

BACKGROUND It has been suggested that combined modalities (methods of treatment) are more effective than single modalities in preventing venous thromboembolism (defined as deep vein thrombosis and pulmonary embolism, or both) in high-risk patients. OBJECTIVES To assess the efficacy of intermittent pneumatic leg compression combined with pharmacological prophylaxis versus single modalities in preventing venous thromboembolism in high-risk patients. SEARCH STRATEGY The Cochrane Peripheral Vascular Diseases (PVD) Group searched their Specialized Register (last searched 17 July 2007) and the Cochrane Central Register of Controlled Trials (CENTRAL) (last searched The Cochrane Library 2008, Issue 3). We searched the reference lists of relevant articles to identify additional trials. SELECTION CRITERIA Randomized controlled trials (RCTs) or controlled clinical trials (CCTs) of combined intermittent pneumatic leg compression and pharmacological interventions used to prevent venous thromboembolism in high-risk patients. DATA COLLECTION AND ANALYSIS Data extraction was undertaken independently by two review authors using data extraction sheets. MAIN RESULTS Eleven studies, six of them randomized controlled trials, were identified. The trials included 7431 patients, in total. Compared with compression alone, the use of combined modalities reduced significantly the incidence of both symptomatic pulmonary embolism (PE) (from about 3% to 1%; odds ratio (OR) 0.39, 95% confidence interval (CI) 0.25 to 0.63) and deep vein thrombosis (DVT) (from about 4% to 1%; OR 0.43, 95% CI 0.24 to 0.76). Compared with pharmacological prophylaxis alone, the use of combined modalities significantly reduced the incidence of DVT (from 4.21% to 0.65%; OR 0.16, 95% CI 0.07 to 0.34) but the included studies were underpowered with regard to PE. The comparison of compression plus pharmacological prophylaxis versus compression plus aspirin showed a non-significant reduction in PE and DVT in favor of the former group. Repeat analysis restricted to the RCTs confirmed the above findings. AUTHORS' CONCLUSIONS Compared with compression alone, combined prophylactic modalities decrease significantly the incidence of venous thromboembolism. Compared with pharmacological prophylaxis alone, combined modalities reduce significantly the incidence of DVT but the effect on PE is unknown. The results of the current review support, especially in high-risk patients, the use of combined modalities. More studies on their role in PE prevention, compared with pharmacological prophylaxis alone, are urgently needed.
Performance investigation on constraint sufficient statistics distributed particle filter

The constraint sufficient statistics distributed particle filter is a novel and effective solution for bearings-only single target tracking. The algorithm achieves a significant reduction in communication overhead by factorizing the likelihood function without suffering a major decrease in accuracy. However, the algorithm has some limitations which we discuss and explore in this paper. In particular, the algorithm has a bias induced via the approximate likelihood calculation, depending on the geometry of the sensors relative to the target.