Miracle-dz/UniFAR-FTUs huggingface dataset:
An Adenovirus Type 5 Mutant with the Preterminal Protein Gene Deleted Efficiently Provides Helper Functions for the Production of Recombinant Adeno-Associated Virus

ABSTRACT Production of recombinant adeno-associated virus (rAAV) requires helper functions that have routinely been provided by infection of the producer cells with adenovirus. Complete removal and/or inactivation of progeny adenovirus, present in such rAAV preparations, presents significant difficulty. Here, we report that an adenovirus type 5 (Ad5) mutant with the preterminal protein (pTP) gene deleted can provide helper function for the growth of rAAV. At high multiplicity, Ad5dl308ΔpTP was as efficient as the phenotypically wild-type Ad5dl309 in permitting growth of rAAV. Use of Ad5dl308ΔpTP, which is incapable of replication in the absence of complementation for pTP, as a helper avoids the need to remove contaminating adenovirus infectious activity by heat inactivation or by purification. Comparison of the transducing ability of rAAV generated with either Ad5dl308ΔpTP or Ad5dl309 as a helper demonstrated that the heat inactivation protocol generally used does not remove all of the helper Ad5dl309 function.
Evaluating power and energy consumption of FPGA-based custom computing machines for scientific floating-point computation

This paper evaluates the actual power consumption and the total energy for scientific floating-point computations accelerated by FPGA-based custom computing machines. With our FPGA-based machines: the streaming accelerator for computational fluid dynamics and the programmable systolic-array processor for numerical simulations based on difference schemes, we measure the power of the entire systems including a host PC and an FPGA board, and obtain the total energy for each computation. We report that the FPGAs perform the same computation with 5% to 30% of the total energy consumed by a microprocessor, while the FPGAs accelerate the computation.
Does the p53 Up-Regulated Gadd45 Protein Have a Role in Excision Repair?

in the edge velocity may have been perceived by the animal because of the curvature of the eye. 18. The value of ox, when measured in conditions of translating and looming stimuli, ranged between 2.9 and 15 rad 1 for angular velocities between 314 and 625 degrees s 1 in different animals. Single exponential fits were consistently better than linear fits; determination coefficients (r2) are 0.962 and 0.935 for exponential fits for Figs. 2E (625 degrees s'1) and 2F (-625 degrees s-1) versus 0.850 and 0.835 for linear fits, respectively. 19. M. O'Shea and C. H. Rowell, J. Exp. Biol. 65, 289 (1976). 20. The exact value of C is unimportant; it is not the absolute firing rate that matters, but the fact that the firing rate peaks and then decreases. 21. The function f (t) will peak when its time derivative is 0. From Eq. 1, df/dt = 0 if 0(tpeak -) =i02(tpeak -) From simple geometrical considerations (Fig. 1 A), 0(t)
Making Connections : Linking Marketing Knowledge and Culture to Entrepreneurial Marketing

Innovation is the lifeblood of entrepreneurship. Innovation, as a construct linking novelty and creativity and the ability to learn, is the key differentiator between entrepreneurial marketing and mainstream marketing. How can this mix be enabled? is a central question for entrepreneurial marketing as a discipline, or sub-discipline. This paper addresses the connections to be made between creating marketing knowledge and using it. To learn there needs to be shared meaning and these meanings have to be shared within and across organisations and their customers. These patterns of meanings therefore have to cross cultures. We propose a couple of conceptual models that link dynamic culture creation with learning, with external market information and signals. We ask the following questions: How can this be useful in enabling innovation? How might these issues be relevant to marketing entrepreneurship? In sum, how in product and service innovation it is possible to discern and develop patterns of meaning between the firm and its network of stakeholders. INTRODUCTION Increasingly the firm is seen as a social community, whose central function is the transfer of knowledge (Hampden-Turner, 1999, Kogut & Zander, 1993), or as a series of re-negotiated contracts (Kay, 1995), where managers, and therefore, marketers, are less rational planners and more ‘symbolic actors, whose primary function is to develop desirable patterns of meaning’ (Starkey, 1998, p.125). The marketing question is how desirable patterns of meaning can be understood and conveyed cross-culturally, both within the firm and to a range of stakeholders. In other words, there is a need for understanding to transcend cultural borders in terms of staff, suppliers and customers. This would appear to be the case regardless of size of firm. Indeed a smaller firm may be able to pay heed to this more easily. An entrepreneurial firm needs to continue to develop these patterns of meaning in order to continue to innovate. The flexibility required for success in start-up situations may be linked to the shared mindset required for successful learning. This need highlights the value of nurturing any latent capacity for learning and those skills that enable and motivate learning, in order to develop shared understandings of all the cultures crossed. Western firms often miss the pivotal place of this ability to learn. For Hamel, Doz and Prahalad (1989) lament that where: the Japanese have generally learnt more than their UK or US partners, this is not due to oriental deviousness, but to occidental indolence. The key to competing through collaboration is to have the mindset to learn. (p.147)
Signet ring cell differentiation in mucinous colorectal carcinoma

Approximately 10% of all colorectal carcinomas are mucinous carcinomas, characterized by extracellular mucin. Occasionally, mucin accumulates intracellularly in these tumours, causing signet ring cell differentiation. We hypothesized that signet ring cells arise from a separate genetic pathway. In this study the molecular background of signet ring cell differentiation was investigated by analysing genetic changes, changes in the expression of adhesion molecules, and mucin content. Furthermore, its clinical relevance was addressed.
Extraction of Graph Information Based on Image Contents and the Use of Ontology.

A graph is an effective form of data representation used to summarize complex information. Explicit information such as the relationship between the Xand Y-axes can be easily extracted from a graph by applying human intelligence. However, implicit knowledge such as information obtained from other related concepts in an ontology also resides in the graph. As this is less accessible, automatic graph information extraction could prove beneficial to users. In this study, we proposed a novel method for extracting both explicit and implicit knowledge from graphs. This was based on our ontology that uses essential information pertaining to the graph and sentence dependency parsing. We focused on two graph types: bar graphs and two-dimensional (2D) charts. Different graph types require different extraction methods and have different extractable features. From the bar graph, we extracted axis labels, the global trend in the data, and the height of the bars. From the 2D charts, we additionally obtained local trends and regression types. The objective was to propose a method for acquiring the implicit and explicit information available in the graphs and entering this into our ontology. For evaluation purposes, we simulated an inquiry involving five questions. Accurate answers were retrieved and significant results were achieved by the shared concepts used in our ontology.
Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in subjects with type 2 diabetes mellitus: a randomized controlled trial: the Italian Diabetes and Exercise Study (IDES).

BACKGROUND This study aimed to assess the efficacy of an intensive exercise intervention strategy in promoting physical activity (PA) and improving hemoglobin A(1c)(HbA(1c)) level and other modifiable cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM). METHODS Of 691 eligible sedentary patients with T2DM and the metabolic syndrome, 606 were enrolled in 22 outpatient diabetes clinics across Italy and randomized by center, age, and diabetes treatment to twice-a-week supervised aerobic and resistance training plus structured exercise counseling (exercise group) vs counseling alone (control group) for 12 months. End points included HbA(1c) level (primary) and other cardiovascular risk factors and coronary heart disease risk scores (secondary). RESULTS The mean (SD) volume of PA (metabolic equivalent hours per week) was significantly higher (P < .001) in the exercise (total PA [nonsupervised conditioning PA + supervised PA], 20.0 [0.9], and nonsupervised, 12.4 [7.4]) vs control (10.0 [8.7]) group. Compared with the control group, supervised exercise produced significant improvements (mean difference [95% confidence interval]) in physical fitness; HbA(1c) level (-0.30% [-0.49% to -0.10%]; P < .001); systolic (-4.2 mm Hg [-6.9 to -1.6 mm Hg]; P = .002) and diastolic (-1.7 mm Hg [-3.3 to -1.1 mm Hg]; P = .03) blood pressure; high-density lipoprotein (3.7 mg/dL [2.2 to 5.3 mg/dL]; P < .001) and low-density lipoprotein (-9.6 mg/dL [-15.9 to -3.3 mg/dL]; P = .003) cholesterol level; waist circumference (-3.6 cm [-4.4 to -2.9 cm]; P < .001); body mass index; insulin resistance; inflammation; and risk scores. These parameters improved only marginally in controls. CONCLUSIONS This exercise intervention strategy was effective in promoting PA and improving HbA(1c) and cardiovascular risk profile. Conversely, counseling alone, though successful in achieving the currently recommended amount of activity, was of limited efficacy on cardiovascular risk factors, suggesting the need for a larger volume of PA in these high-risk subjects. Trial Registration isrctn.org Identifier: ISRCTN04252749.
How hard is it to automatically translate phrasal verbs from English to French?

The translation of English phrasal verbs (PVs) into French is a challenge, specially when the verb occurs apart from the particle. Our goal is to quantify how well current SMT paradigms can translate split PVs into French. We compare two inhouse SMT systems, phrase-based and hierarchical, in translating a test set of PVs. Our analysis is based on a carefully designed evaluation protocol for assessing translation quality of a specific linguistic phenomenon. We find out that (a) current SMT technology can only translate 27% of PVs correctly, (b) in spite of their simplistic model, phrase-based systems outperform hierarchical systems and (c) when both systems translate the PV similarly, translation quality improves.
Radiation‐induced necrosis and calcinosis of the breast: a case report

anatomically favourable dissection plane harnessed surgically in the elevation of skin flaps – providing a ‘path of least resistance’ and the rationale for why the true involved area may extend insidiously well beyond clinically identifiable boundaries. Further complicating the clinical picture, NF rarely may present at multiple non-contiguous sites. El-Khani et al. identified 31 citations for multifocal disease in the sole systematic review on the topic with one-third of the patients undergoing surgical debridement on average 7.8 days post admission, suggesting a delay in recognition. Small numbers and data heterogeneity limit what can be extrapolated from the series, but little appears to distinguish those from monofocal disease. There were, however, a number of notable observations. First and perhaps unsurprisingly, mortality (43%) was higher, likely attributable to the difficulty in achieving adequate surgical debridement. Secondly, in contrast to the trends seen in monofocal disease – where polymicrobial (type 1) infection predominates over monomicrobial (type 2) infection (80% versus 20%) – in multifocal NF, the incidence of monomicrobial, and in particular GAS infection, was much higher (52%). This is theoretically plausible. GAS virulence is well recognized being associated with a bacteraemia and toxic shock syndrome, and this systemic involvement would be consistent with septic embolization and disseminated infection. Lastly, there is often three-to-four limb involvement (15/33 cases in the series). In our case, non-contiguous right upper and lower limb lesions developed within 24 h of admission, and likely new septic lesions in the remaining limbs not 12 h subsequent to debridement. Subacute progression of the disease has been documented as late as 9 days post-admission. In our experience, the unusual presentation of the disease may have contributed to a delay in surgical referral and the time to definitive intervention. Prompt surgical referral for exploration/debridement of any patient with a similar clinical picture is recommended.
Measurement of oxygen consumption in infants.

Sir, The paper by Evans et al. (Archives, 1978, 53, 330) describing a simple method for measuring oxygen consumption contains inaccuracies I should like to correct. The assertion that methods using a lower flow rate 'almost certainly result in CO2 retention' is wrong. The method described by me (Smales, 1978) uses a flow rate of 1 1/min and by sampling continuously from the nares in a term infant we were unable to demonstrate any alteration in the CO2 profile using the Edward's medishield medical mass spectrometer. At 500 ml/min, however, baseline shift was observed. In addition when oxygen consumption was measured at various flow rates between 1 and 3 1/min no significant differences were observed. I would suggest that the reason for this is that when a constant bias flow is applied to the proximal channel, flow rates exceeding this may occur during expiration through the distal part of tubing. In the method described by Evans et al. the flow rate of mixed expiratory gases through the distal tubing is constant and must therefore be higher to avoid CO2 retention. Although they omitted my data from their list of comparative values of V02 in neonates, Evans et al. will find that there is also close agreement with previous workers. 0. R. C. SMALES Nottingham City Hospital, Hucknall Road, Nottingham NGS JPB
Fuzzy model-based decentralized robust piecewise static output feedback control for discrete-time large-scale nonlinear systems

This paper investigates the problem of decentralized robust output feedback control for a class of discrete-time large-scale nonlinear systems. The considered large-scale system consists of several nonlinear subsystems with interconnections and parametric uncertainties, and each nonlinear subsystem is represented by a Takagi–Sugeno (T–S) model. Our objective is to design a decentralized robust piecewise static output feedback (SOF) controller such that the closed-loop fuzzy control system is asymptotically stable with an disturbance attenuation level. Based on a piecewise Lyapunov function combined with some matrix inequality linearization techniques, and the descriptor system approach, sufficient conditions on the existence of a decentralized piecewise SOF controller are derived for the underlying large-scale T–S fuzzy system in terms of linear matrix inequalities. The effectiveness of the obtained results in this paper is validated by two numerical examples.
Géométrie et inférence dans l'optimisation et en théorie de l'information

Les problemes d'optimisation et de satisfaction de contraintes sur des ensembles de variables discretes sont l'objet principal de la complexite algorithmique. Ces problemes ont recemment beneficie des outils et des concepts de la physique des systemes desordonnes, a la fois theoriquement et algorithmiquement. En particulier, il a ete suggere que les difficultes pratiques soulevees par certaines instances dures de problemes d'optimisation sont liees a la structure fragmentee de leur espace de solutions, qui rappelle une phase vitreuse. Parallelement, les codes de correction d'erreur de pointe, qui peuvent etre ramenes a des problemes d'optimisation, reposent sur la separabilite de leurs messages afin d'assurer une communication fiable. L'objet de cette these est d'explorer, dans un cadre commun, cette relation entre les proprietes d'inference et l'organisation geometrique, dans les problemes issus de la complexite algorithmique et de la theorie de l'information. Apres une introduction physique des problemes et des concepts lies aux domaines sus-evoques, les methodes de passage de messages, basees sur l'approximation de Bethe, sont introduites. Ces methodes sont utiles d'un point de vue physique, car elle permettent d'etudier les proprietes thermodynamiques d'ensemble d'instances aleatoires. Elles sont egalement utiles pour l'inference. L'analyse de spectres de distances est ensuite effectuee a l'aide de methodes combinatoires et de passage de messages, et mises a profit afin de prouver et l'existence de la fragmentation dans les problemes de satisfaction de contraintes, et d'en etudier les aspects importants.
The Effects of Natural Flavonoids on Lipoxygenase-Mediated Oxidation of Compounds with a Benzene Ring Structure—A New Possible Mechanism of Flavonoid Anti-Chemical Carcinogenesis and Other Toxicities

Numerous studies have strongly suggested that flavonoids exhibit antimutagenic, anticarcinogenic, antiallergic, and anti-inflammatory properties, but the mechanism is still far from clear. In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated. Green tea polyphenol, epigallocatechin gallate, quercetin, and rutin can reduce the co-oxidation reaction speed of tested compounds mediated by soybean lipoxygenase and the production of oxidative products and free radical intermediates. Their median inhibition concentrations on guaiacol oxidation mediated by soybean lipoxygenase were 8.22 mg·L−1, 17.8 μmol·L−1, 41.5 μmol·L−1, and 46.3 μmol·L−1, respectively. These were all significantly lower than glutathione, dithiothreitol, butylated hydroxyanisole and gossypol. The data collected in this study suggest that flavonoids may have an anticarcinogenicity and antitoxicity effect through inhibition of oxidative activation.
The Influence of Quality of Management Accounting Information System on the Implementation of Good Corporate Governance and It Impacts on the Company Performance

The decrease of sharia commercial banks performance in the several years (2014-2017) may be caused by the low of implementation of good corporate governance’s (GCG) principles. And the low of implementation can caused by the low of Quality of Management Accounting Information System (QMAIS). This study aims to prove empirically that QMAIS can influence the implementation of GCG so that it has impact on company performance. The study uses survey as the research method which the method of data collection is by distributing the questionnaire to the managers in the middle management level. The research population is 42 banks of all banking institutions in Bandung City with the target population are 12 banks of all Sharia Commercial Banks in Bandung. The sampling technique uses convenience sampling. Further, the hypothesis testing will be done by using SEM-PLS statistical techniques. The study results show that QMAIS does not have influence on the implementation of GCG. Then, the implementation of GCG has positive and significant influence on company performance, it can be interpreted that the better the implementation of GCG, the better the company performance. Keywords—quality of management accounting information system; good corporate governance; company performance
Procedure guidelines for dynamic renal scintigraphy

Summary: This procedure guideline describes the procedures for dynamic renal scintigraphy with 99mTc-MAG3, 123I-hippuran and 99mTc-DTPA. Common clinical applications as well as a detailed description of the procedure are given. It also includes explanations and hints concerning the analysis, evaluation, interpretation, and presentation of the findings.
Effective dynamic susceptibility of a one-dimensional array of ferromagnetic wires

In this paper the calculation of the effective dynamic susceptibility for a one-dimensional array of permalloy rectangular nanowires periodic along the in-plane x direction is presented. The external magnetic field is assumed aligned along the long side of the wires (y direction) and the in-plane Bloch wave vector is along the wires width (x direction). The calculation is performed by means of a finite-difference micromagnetic approach, the Lagrangian-based dynamical matrix method. It is shown that the excited spin-wave mode is always the quasi-uniform or fundamental mode of the spectrum. This spin excitation has a non-uniform amplitude along the wire width due to confinement with no nodal planes and can be regarded as the metamaterial wave of the one-dimensional periodic system.
Validation of a rapid neurodevelopmental assessment tool for 10- to 16-year-old young adolescents in Bangladesh.

OBJECTIVE To validate a Rapid Neurodevelopmental Assessment (RNDA) tool for use by child health professionals to determine neurodevelopmental impairments (NDIs) in young adolescents aged 10-16 years in Bangladesh. STUDY DESIGN In a convenience sample of community children (n = 47), inter-rater reliability was determined between four testers, and concurrent validity was determined by simultaneous administration of an intelligence quotient (IQ) test (Wechsler Intelligence Scale for Children, Revised) by a child psychologist. RESULTS Inter-rater reliability was excellent between the testers on the 47 children administered the RNDA (kappa = 1.00). Significantly lower IQ scores were obtained in those identified with 'any (>1) NDI' (n = 34) compared with those with no NDI (n = 13) on Verbal IQ (P-value < 0.0001), Performance IQ (P-value < 0.0001) and Full-scale IQ (P-value < 0.0001) scores on the Wechsler Intelligence Scale for Children, Revised. CONCLUSION The RNDA shows promise as a tool for use by child health professionals for identifying NDIs in young adolescents aged 10-16 years. A larger study sample is needed to determine its usefulness for identification of some impairments not found in the study population, i.e. gross motor, fine motor, hearing and seizures.