Miracle-dz/UniFAR-FTUs huggingface dataset:
The prevalence of metabolic syndrome and Framingham cardiovascular risk scores in adult inpatients taking antipsychotics - a retrospective medical records review.

BACKGROUND The objective of this retrospective records review was to evaluate the prevalence of metabolic syndrome (MetS) and Framingham cardiovascular risk scores in adult inpatients taking antipsychotics. SUBJECTS AND METHODS Hospital records of 62 patients (27 women and 35 men) taking antipsychotics were retrospectively reviewed for: body height and weight, waist circumference, cigarette smoking, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides (TGA), fasting plasma glucose (FPG), blood pressure, concomitant use of antidiabetic, antihypertensive and antihyperlipidemic medications. RESULTS MetS was diagnosed in 29.0% (ATPIII), 35.5% (ATPIII A) and 41.9% (IDF) of patients. The prevalence of MetS components was: central obesity 50.0% (ATPIII and ATPIII A), 75.8% (IDF); hypertension 40.3% (ATPIII, ATPIII A and IDF); reduced HDL cholesterol 51.6% (ATPIII, ATPIII A and IDF); raised TGA 38.7% (ATPIII and ATPIII A), 41.9% (IDF); raised FPG 11.3% (ATPIII), 24.2% (ATPIII A) and 24.2% (IDF). Most of cardiovascular risk scores were higher in subjects with MetS. Mean BMI (28.4 kg/m2) and waist circumference (97.8 cm) were above cut-points for overweight and IDF-defined abdominal obesity. Mean total cholesterol (203.2 mg/dL) and TGA (159.1 mg/dL) levels were above upper limit of normal ranges. Overweight or obesity and abdominal obesity (more frequent in women: 88.9% vs. 65.7%; P=0.035) were found in 69.4% and 75.8% of the patients, respectively. Over 60% of subjects with hyperlipidemia (77.4% of the whole group) had no hypolipidemic therapy on discharge. CONCLUSIONS The prevalence of MetS in subjects taking antipsychotics exceeds the prevalence in general population. Its presence increases the risk of cardiovascular events. Increased body weight and metabolic abnormalities were frequent in our group of patients (particularly in women) taking antipsychotics. Most patients with hyperlipidemia had no antihyperlipidemic introduced.
DISTRIBUTION OF AN IDIOTYPE IN INBRED IV[ICE

Idiotypic determinants are present on myeloma proteins (1) and on induced antibodies (2, 3), where they are characterized by their association with antibody of a given specificity. Shared determinants are ordinarily not detectable in nonspecific IgG, 1 in preimmune serum, nor in antibodies of other specificities from the same animal. As would be predicted, idiotypic determinants are localized in the Fab fragment of immunoglobulin molecules (6). In many antibodies the region of the active site appears to be an important idiotypic determinant, as shown by the capacity of specific haptens to inhibit the reaction with anti-idiotypic antibody (7-10). 2 Complete blocking by haptens is generally not observed, which suggests the presence of additional idiotypic determinants on the Fab fragment. This is supported by the capacity of Fab fragments from some, although not all, immunoglobulins to form specific precipitates with their anti-idiotypic antibodies (11); this property would require antigenic multivalence. Mice of an inbred strain are frequently observed to produce antibodies of a given specificity with shared idiotype. Intrastrain cross-reactions have been observed among the anti-phosphorylcholine (anti-PC) 3 antibodies of different BALB/c mice (12, 13), the anti-p-azobenzoate antibodies of A/J mice (14), A/J anti-p-azophenylarsonate (anti-At) antibodies (14), BALB/c anti-p-azobenzoate antibodies (14), BALB/c anti-oe,l,3-dextran antibodies (15), and A/J antistreptococcal carbohydrate antibodies (16). In contrast, intrastrain idiotypic cross-reactions among the anti-p-
On the relationships of DIN xs , nitrogen fixation and differential remineralization in the North Atlantic ocean

We use a combination of simple scalings and analytical expressions as well as an 10 idealized numerical model of basin-scale circulation, biogeochemical cycles and ecology, to elucidate and illustrate factors which regulate the distribution of tracer DINxs = NO − 3 − 16PO 4 , its temporal variability, and the distribution of diazotrophs in the North Atlantic. We infer that the observed subsurface maximum of DINxs in the subtropical thermocline and increase in temporal variability of DINxs with depth are both consistent with 15 an enhanced remineralization rate for organic phosphorus, relative to organic nitrogen. The observed confinement of diazotrophs largely to warm, tropical waters can be (partly) explained in terms of resource control, competitive in more oligotrophic, nitrogen limited waters, but themselves inviable due to phosphorus limitation in the most oligotrophic waters of the models subtropics. 20
USC at THUMOS 2014

We submitted one run for THUMOS 2014 action recognition task. The system used improved dense trajectory features and fisher vector coding. Since testing videos are temporally untrimmed, we applied a sliding window of 100 frames for both training and testing videos. We utilized the background videos by iteratively training SVM classifiers and selecting hard negative samples. Video-level scores were generated by maximum pooling.
SMARTPAPER: An Interactive and User Friendly Sketching System

This paper describes an interactive sketching system for 3D design/modeling that diverts from the conventional menu‐and‐button interfaces of CAD tools. The system, dubbed SMARTPAPER, offers a unified sketching environment that supports direct sketching as well as gestured sketching with more emphasis on the former to encourage natural sketching styles. SMARTPAPER also provides a unified 2D and 3D drawing domain by allowing the user to sketch directly on a 3D model in addition to the usual 2D sketching from scratch. A natural sketching experience is offered by supporting casual sketching consisting of wiggly, discontinuous, overlapping strokes. The system is empowered by an array of seamlessly integrated 2D and 3D features such as 2D sketch cleaning, 3D reconstruction from 2D sketch, 3D transformations, sketching on 3D, and conventional 3D CSG operations like cutting and joining. The key to the success of SMARTPAPER is efficient and robust 3D reconstruction from a single freehand 2D sketch with minimal hints. We have employed and improved Lipson's optimization method, originally designed for offline reconstruction of engineering drawings, in our interactive system by leveraging additional clues obtained by interaction during sketching.
E2F and Ras Synergize in Transcriptionally Activating p14ARF Expression

The INK4a/ARF locus, which is frequently inactivated in human tumors, encodes two distinct tumor suppressive proteins, ARF and p16INK4a. ARF stabilizes and activates p53 by negating the effects of mdm2 on p53. Furthermore, its function is not restricted to the p53 pathway and it also inhibits cell proliferation in cells lacking p53. Expression of ARF is up-regulated in response to a number of oncogenic stimuli including E2F1. We show here that while oncogenic Ras does not significantly affect p14ARF expression in normal human cells it activates p14ARF in cells containing deregulated E2F. Moreover, oncogenic Ras and E2F1 synergize in activating p14ARF expression. Activation of p14ARF promoter by E2F1 persists in the absence of the consensus E2F-binding sites in this promoter, indicating that this activation also occurs through non- canonical binding sites. The activation by oncogenic Ras requires both E2F and Sp-1 activity, demonstrating the complex regulation of p14ARF in response to oncogenic stimuli.
Rule Based Replacement of Pronoun by Corresponding Noun for Bangla News Documents

The object of this research work is to replace pronoun by corresponding noun for Bangla news documents. To the best of our knowledge, this is the first initiative to solve the problem of dangling pronoun where corresponding noun is not available. If the information retrieval procedures extract any sentence with dangling pronoun, it may raise confusion to the user. To mitigate this problem, a method has been proposed here by using general and special tagging, dependency parsing, full name identifying and finally pronoun replacing. For achieving the target of this method, 3000 Bangla news documents have been analyzed and some grammar books have been studied. Seven knowledgeable persons in the arena of Bangla language also helped us in this research work. Finally, the proposed method shows 71.80% accuracy in the evaluation for replacing pronoun.
A 10 MS / s 11b 0 . 19 mm 2 Algorithmic ADC with Improved Clocking

A 10Ms/s 11-b algorithmic ADC with an active area of 0.19mm is presented. Using an improved clocking scheme, this design overcomes the speed limit of algorithmic ADCs. The proposed ADC employs amplifier sharing, DC offset cancellation, and input memory effect suppression to reduce area and power, and achieve high linearity. The ADC implemented in a 0. 13μm thick gate-oxide CMOS process achieves 69dB SFDR, 58dB SNR, and 56dB SNDR, while consuming 3.5mA from 3V supply.
Anthropometric factors and risk of molecular breast cancer subtypes among postmenopausal Norwegian women

Adult height and body weight are positively associated with breast cancer risk after menopause, but few studies have investigated these factors according to molecular breast cancer subtype. A total of 18,562 postmenopausal Norwegian women who were born between 1886 and 1928 were followed up for breast cancer incidence from the time (between 1963 and 1975) height and weight were measured until 2008. Immunohistochemical and in situ hybridization techniques were used to subtype 734 incident breast cancer cases into Luminal A, Luminal B [human epidermal growth factor receptor 2 (HER2−)], Luminal B (HER2+), HER2 subtype, basal‐like phenotype (BP) and five‐negative phenotype (5NP). We used Cox regression analysis to assess adult height and body mass index (BMI) in relation to risk of these subtypes. We found a positive association of height with risk of Luminal A breast cancer (ptrend, 0.004), but there was no clear association of height with any other subtype. BMI was positively associated with risk of all luminal breast cancer subtypes, including Luminal A (ptrend, 0.002), Luminal B (HER2−) (ptrend, 0.02), Luminal B (HER2+) (ptrend, 0.06), and also for the HER2 subtype (ptrend, 0.04), but BMI was not associated with risk of the BP or 5NP subtypes. Nonetheless, statistical tests for heterogeneity did not provide evidence that associations of height and BMI differed across breast cancer subtypes. This study of breast cancer risk among postmenopausal women suggests that height is positively associated with risk of Luminal A breast cancer. BMI is positively associated with risk of all luminal subtypes and for the HER2 subtype.
Procedural modeling of cracks and fractures

This work presents a procedural method for modeling cracks and fractures in solid materials such as glass, metal and stone. Existing physically based techniques are computationally demanding and lack control over crack and fracture propagation. Our procedural approach provides the designer with simple tools to control the pattern of the cracks and the size and shape of fragments. Given a few parameters, our method automatically creates a vast range of types of cracks and fragments of different shapes.
Software Module Clustering as a Multi-Objective Search Problem

Software module clustering is the problem of automatically organizing software units into modules to improve program structure. There has been a great deal of recent interest in search-based formulations of this problem in which module boundaries are identified by automated search, guided by a fitness function that captures the twin objectives of high cohesion and low coupling in a single-objective fitness function. This paper introduces two novel multi-objective formulations of the software module clustering problem, in which several different objectives (including cohesion and coupling) are represented separately. In order to evaluate the effectiveness of the multi-objective approach, a set of experiments was performed on 17 real-world module clustering problems. The results of this empirical study provide strong evidence to support the claim that the multi-objective approach produces significantly better solutions than the existing single-objective approach.
Proteomics of Mycoplasma genitalium: identification and characterization of unannotated and atypical proteins in a small model genome.

We present the results of a comprehensive analysis of the proteome of Mycoplasma genitalium (MG), the smallest autonomously replicating organism that has been completely sequenced. Our aim was to identify and characterize all soluble proteins in MG that are structurally and functionally uncharacterized. We were particularly interested in identifying proteins that differed significantly from typical globular proteins, for example, proteins which are unstructured in the absence of a 'partner' molecule or those that exhibit unusual thermodynamic properties. This work is complementary to other structural genomics projects whose primary aim is to determine the three-dimensional structures of proteins with unknown folds. We have identified all the full-length open reading frames (ORFs) in MG that have no homologs of known structure and are of unknown function. Twenty-five of the total 483 ORFs fall into this category and we have expressed, purified and characterized 11 of them. We have used circular dichroism (CD) to rapidly investigate their biophysical properties. Our studies reveal that these proteins have a wide range of structures varying from highly helical to partially structured to unfolded or random coil. They also display a variety of thermodynamic properties ranging from cooperative unfolding to no detectable unfolding upon thermal denaturation. Several of these proteins are highly conserved from mycoplasma to man. Further information about target selection and CD results is available at http://bioinfo.mbb. yale.edu/genome
Deriving translation units using small additional corpora

We present a novel strategy to derive new translation units using an additional bilingual corpus and a previously trained SMT system. The units were used to adapt the SMT system. The derivation process can be applied when the additional corpus is very small compared with the original train corpus and it does not require to compute new word alignments using all corpora. The strategy is based in the Levenshtein Distance and its resulting path. We reported a statistically significant improvement, with a confidence level of 99%, when adapting an Ngram-based CatalanSpanish system using an additional corpus that represents less than 0.5% of the original train corpus. The additional translation units were able to solve morphological and lexical errors and added previously unknown words to the vocabulary.
Effects of Organizational Characteristics on Outcomes and Resource Use in Patients With Cancer Admitted to Intensive Care Units.

PURPOSE To investigate the impact of organizational characteristics and processes of care on hospital mortality and resource use in patients with cancer admitted to intensive care units (ICUs). PATIENTS AND METHODS We performed a retrospective cohort study of 9,946 patients with cancer (solid, n = 8,956; hematologic, n = 990) admitted to 70 ICUs (51 located in general hospitals and 19 in cancer centers) during 2013. We retrieved patients' clinical and outcome data from an electronic ICU quality registry. We surveyed ICUs regarding structure, organization, staffing patterns, and processes of care. We used mixed multivariable logistic regression analysis to identify characteristics associated with hospital mortality and efficient resource use in the ICU. RESULTS Median number of patients with cancer per center was 110 (interquartile range, 58 to 154), corresponding to 17.9% of all ICU admissions. ICU and hospital mortality rates were 15.9% and 25.4%, respectively. After adjusting for relevant patient characteristics, presence of clinical pharmacists in the ICU (odds ratio [OR], 0.67; 95% CI, 0.49 to 0.90), number of protocols (OR, 0.92; 95% CI, 0.87 to 0.98), and daily meetings between oncologists and intensivists for care planning (OR, 0.69; 95% CI, 0.52 to 0.91) were associated with lower mortality. Implementation of protocols (OR, 1.52; 95% CI, 1.11 to 2.07) and meetings between oncologists and intensivists (OR, 4.70; 95% CI, 1.15 to 19.22) were also independently associated with more efficient resource use. Neither admission to ICUs in cancer centers compared with general hospitals nor annual case volume had an impact on mortality or resource use. CONCLUSION Organizational aspects, namely the implementation of protocols and presence of clinical pharmacists in the ICU, and close collaboration between oncologists and ICU teams are targets to improve mortality and resource use in critically ill patients with cancer.
Nuclease hypersensitive regions with adjacent positioned nucleosomes mark the gene boundaries of the PHO5/PHO3 locus in yeast.

The chromatin structure of two tandemly linked acid phosphatase genes (PHO5 and PHO3) from Saccharomyces cerevisiae was analyzed under conditions at which the strongly regulated PHO5 gene is repressed. Digestion experiments with DNase I, DNase II, micrococcal nuclease and restriction nucleases reveal the presence of five hypersensitive sites at the PHO5/PHO3 locus, two of them upstream of PHO5 at distances of 920 and 370 bp, one in between the two genes and two downstream of PHO3. Specifically positioned nucleosomes are located next to these hypersensitive sites as shown by indirect end‐labeling experiments. The positions deduced from these experiments could be verified by monitoring the accessibility of various restriction sites to the respective nucleases. Sites within putative linker regions were about 50‐60% susceptible, whereas sites located within nucleosome cores were resistant. Hybridizing micrococcal nuclease digests to a probe from in between the two upstream hypersensitive sites leads to an interruption of an otherwise regular nucleosomal DNA pattern. This shows directly that these hypersensitive sites represent gaps within ordered nucleosomal arrays.
Research on the Virtual Moving Object Recognition Based on the SSVEP-BCI

In this study, a brain-computer interface (BCI) paradigm based on steady-state visually evoked potentials (SSVEP) has been presented to seek the effects of the movement of the stimulus targets on classification accuracy in virtual environment, which was seldom noticed previously. Several paths including fixed, up/down, broken line, random path, and different speeds were set for searching performances' difference. Experiment results show that the accuracy of this novel paradigm is slightly lower than that of the conventional non-moving paradigms but it might be more practical. And different moving path brought about different performance, especially, crisscross's times was important to subject's judgment, more crisscross with flickering more erroneous judgment occur. It should be a base of target recognition in real environment.
Hepatocyte function in a radial-flow bioreactor using a perfluorocarbon oxygen carrier.

UNLABELLED The aims of this study were, first, to indicate the metabolic activity of hepatocytes in a radial-flow polyurethane foam matrix bioreactor relative to monocultures, and second, to evaluate the effect on the hepatocytes of including a synthetic perfluorocarbon (PFC) oxygen carrier to the recirculating medium. The efficient O2-carrying ability of PFCs may be beneficial to bioreactors employed in stressed cellular environments. Thus, they may also be useful in the treatment of an acute liver failure patient with a bioartificial liver support system (BALSS). Data on the function of three-dimensional (3-D) hepatocyte cultures exposed to emulsified PFCs are lacking. RESULTS the metabolic functions of the 3-D hepatocyte cultures were improved relative to monocultures. Three-dimensional cultures with and without PFC behaved similarly, and no adverse effects could be detected when PFC was included in the recirculating medium. The addition of PFC significantly improved lidocaine clearance possibly due to the presence of higher O2 tension in the medium. Imaging indicated that large aggregates formed and that seeding had followed flow through the matrix. Simulations indicated first, that the cell numbers used in this study had been insufficient to challenge the bioreactor O2 supply explaining the similarity in performance of the 3-D cultures, and second, that the benefit of adding PFC would be more pronounced at the cell densities likely to be used in a BALSS bioreactor.
The Detection of Liquid Slugging Phenomena in Reciprocating Compressors via Power Measurements

The presence of liquid refrigerant in the compressor cylinder during operation, or liquid slugging, is one of the most common causes of failure in reciprocating compressors. We propose to detect this fault by analyzing the electrical current flowing into the compressor and identifying the chan ge in the load on the motor caused by the presence of liquid in the compressor cylinder. Two different types of liquid slugging are examined in this paper. In the first, small volumes of liquid are ingested during the steady-state operation of the compressor; in the second, small volumes of liquid are present at the suction port of the compressor immediately prior to the compressor start. Experimental data from a 1-ton split air conditioning system is used to demonstrate methods for identifying these faults.
Honest signalling in trust interactions: smiles rated as genuine induce trust and signal higher earnings opportunities

We test the hypothesis that smiles perceived as honest serve as a signal that has evolved to induce cooperation in situations requiring mutual trust. Potential trustees (84 participants from Toulouse, France) made two video clips averaging around 15 seconds for viewing by potential senders before the latter decided whether to ‘send’ or ‘keep’ a lower stake (4 euro) or higher stake (8 euro). Senders (198 participants from Lyon, France) made trust decisions with respect to the recorded clips. If money was sent to the trustee, stakes were tripled and trustees could decide to keep all, two thirds or one half of the tripled stakes. Clips were further rated concerning the genuineness of the displayed smiles. We observe that smiles rated as more genuine strongly predict judgments about the trustworthiness of trustees, and willingness to send them money. We observe a relation between costs and benefits: smiles from trustees playing for higher stakes are rated as significantly more genuine. Finally, we show that those rated as smiling genuinely return more money on average to senders. An increase of one standard deviation in rating of smile genuineness is associated with an unconditional expected gain of about one dollar and thirty cents to senders in the two trials of the experiment. Potential gains for senders could be significantly increased from taking smiles rated as genuine into account.