Miracle-dz/UniFAR-FTUs huggingface dataset:
Visual Navigation for Micro Air Vehicles

Recent advances in state estimation, planning, mapping, and control algorithms combined with ever-increasing computational power available onboard micro air vehicles have enabled a number of researchers to demonstrate advanced autonomous capabilities in GPS-denied environments. Much of this work has focused around the use of laser range-finder sensors, however the use of a 2D sensor in a 3D environment requires a number of assumptions that limit the ability of the MAV to operate in unconstrained environments. In this talk, we describe a system for visual odometry and mapping using a stereo or RGB-D camera. By leveraging results from recent state-of-the-art algorithms and hardware, our system enables 3D flight and planning in cluttered environments using only onboard sensor data.
Identification of essential loops and residues of glucosyltransferase V (GtrV) of Shigella flexneri

Lipopolysaccharide (LPS), particularly the O-antigen component, is one of many virulence determinants necessary for Shigella flexneri pathogenesis. O-antigen modification is mediated by glucosyltransferase (gtr) genes encoded by temperate serotype-converting bacteriophages. The gtrV and gtrX genes encode the GtrV and GtrX glucosyltransferases, respectively. These are integral membrane proteins, which catalyze the transfer of a glucosyl residue via an α1,3 linkage to rhamnose II and rhamnose I of the O-antigen unit. This mediates conversion of S. flexneri serotype Y to serotype 5a and X, respectively. Essential regions in the topology of GtrV protein were identified by in vivo recombination and a PCR-mediated approach. A series of GtrX-GtrV and GtrV-GtrX chimeric proteins were constructed based on the fact that GtrV and GtrX share sequence similarity. Analysis of their respective serotype conversion abilities led to the identification of two important periplasmic loops: loops No 2 and No 10 located in the N- and C-termini, respectively. Within these two loops, three conserved motifs were identified; two in loop No 2 and one in loop No 10. These conserved motifs contain acidic residues which were shown to be critical for GtrV function.
Memory of the Traumatic Event is Associated With Increased Risk for PTSD: A Retrospective Study of Patients With Traumatic Brain Injury

ABSTRACT Studies of the relationship between explicit episodic memory of a traumatic event (MTE) and posttraumatic stress disorder (PTSD) are inconclusive. The authors examined whether memory for the details of the traumatic event as reported by patients with mild traumatic brain injury was associated with the development of PTSD. In a retrospective study of 120 participants, MTE was found to be associated with an increased risk of PTSD, particularly for the reexperiencing symptom cluster. Although less frequently, PTSD was nonetheless present even in the absence of explicit memory. Possible explanations for mechanisms that enable this phenomenon are considered.
Adapting an English Information Extraction System to Swedish

This paper presents work on adapting the Proteus Information Extraction sys­ tem to Swedish. It turned out that the cross-lingual adaptation as such was fairly straight-forward; however, the Proteus system design did not render itself that well to reconfiguration at such a low level as needed. To evaluate the adaptation, the system was tested on a Swedish version of the MUC-6 Scenario Template Task. The Swedish version performed excellently on a training corpus, but quite discouragingly on an unseen test corpus. As a consequence of that work, a new Information Extraction system is being designed and the layout of that system is described.
Draft Genome Sequence of Pseudomonas sp. Strain LFM046, a Producer of Medium-Chain-Length Polyhydroxyalkanoate

ABSTRACT Pseudomonas sp. LFM046 is a medium-chain-length polyhydroxyalkanoate (PHAMCL) producer capable of using various carbon sources (carbohydrates, organic acids, and vegetable oils) and was first isolated from sugarcane cultivation soil in Brazil. The genome sequence was found to be 5.97 Mb long with a G+C content of 66%.
Dual margin approach on a Lagrangian support vector machine

In this paper, we propose a new support vector machine (SVM) called dual margin Lagrangian support vectors machine (DMLSVM). Unlike other SVMs which use only support vectors to determine the separating hyperplanes, DMLSVM utilizes all the available training data for training the classifier, thus producing robust performance. The training data are weighted differently depending on whether they are in a marginal region or surplus region. For fast training, DMLSVM borrows its training algorithm from Lagrangian SVM (LSVM) and tailors the algorithm to its formulation. The convergence of our training method is rigorously proven and its validity is tested on a synthetic test set and UCI dataset. The proposed method can be used in a variety of applications such as a recommender systems for web contents of IPTV services.
Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers

Background The potential predictive role of programmed death-ligand-1 (PD-L1) expression on tumor cells in the context of solid tumor treated with checkpoint inhibitors targeting the PD-1 pathway represents an issue for clinical research. Methods Overall response rate (ORR) was extracted from phase I-III trials investigating nivolumab, pembrolizumab and MPDL3280A for advanced melanoma, non-small cell lung cancer (NSCLC) and genitourinary cancer, and cumulated by adopting a fixed and random-effect model with 95% confidence interval (CI). Interaction test according to tumor PD-L1 was accomplished. A sensitivity analysis according to adopted drug, tumor type, PD-L1 cut-off and treatment line was performed. Results Twenty trials (1,475 patients) were identified. A significant interaction (p<0.0001) according to tumor PD-L1 expression was found in the overall sample with an ORR of 34.1% (95% CI 27.6-41.3%) in the PD-L1 positive and 19.9% (95% CI 15.4-25.3%) in the PD-L1 negative population. ORR was significantly higher in PD-L1 positive in comparison to PD-L1 negative patients for nivolumab and pembrolizumab, with an absolute difference of 16.4% and 19.5%, respectively. A significant difference in activity of 22.8% and 8.7% according to PD-L1 was found for melanoma and NSCLC, respectively, with no significant difference for genitourinary cancer. Conclusion Overall, the three antibodies provide a significant differential effect in terms of activity according to PD-L1 expression on tumor cells. The predictive value of PD-L1 on tumor cells seems to be more robust for anti-PD-1 antibody (nivolumab and pembrolizumab), and in the context of advanced melanoma and NSCLC.
Evaluation of infertile women: Mini-review

Evaluation of infertility indicated for women failed to conceive after one year of unprotected intercourse and for women over 35 years failed to conceive after 6 mo of unprotected intercourse, because the fertility decline as women approach 40 years. Evaluation of infertile couple should begin with semen analysis of male partner. If the semen analysis is within normal range, evaluation then move on to female partner. Evaluation of the infertile woman should be carried in cost-effective manner to identify the causes of infertility using the least invasive methods. Methods of evaluation of infertile women include: 1) history and physical examination; 2) evaluation of the male partner; 3) documentation of ovulation; 4) evaluation of the ovarian reserve; 5) evaluation of cervical causes of infertility; 6) evaluation of uterine causes of infertility; 7) documentation of the tubal patency; and 8) exclusion of peritoneal causes of infertility. Evaluation of infertile couple should include evaluation of both partners. Semen analysis for the male partner, followed by documentation of ovulation and evaluation of genital tract patency. PCT is not used as routine evaluation of infertile women. Laparoscopy is not used as routine evaluation of infertile women unless there is suspected peritoneal factors of infertility or endometriosis or tubal occlusion. Ovarian reserve should only be done for infertile women with diminished response to external gonadotropins (not routine).
Cancer Therapy: Preclinical GDC-0941, a Novel Class I Selective PI3K Inhibitor, Enhances the Efficacy of Docetaxel in Human Breast CancerModels by Increasing Cell Death In Vitro and In Vivo

Purpose: Docetaxel is a front-line standard-of-care chemotherapeutic drug for the treatment of breast cancer. Phosphoinositide 3-kinases (PI3K) are lipid kinases that regulate breast tumor cell growth, migration, and survival. The current study was intended to determine whether GDC-0941, an orally bioavailable class I selective PI3K inhibitor, enhances the antitumor activity of docetaxel in human breast cancer models in vitro and in vivo. Experimental Design: A panel of 25 breast tumor cell lines representing HER2þ, luminal, and basal subtypes were treated with GDC-0941, docetaxel, or the combination of both drugs and assayed for cellular viability, modulation of PI3K pathway markers, and apoptosis induction. Drug combination effects on cellular viability were also assessed in nontransformed MCF10A humanmammary epithelial cells. Human xenografts of breast cancer cell lines and patient-derived tumors were used to assess efficacy of GDC-0941 and docetaxel in vivo. Results: Combination of GDC-0941 and docetaxel decreased the cellular viability of breast tumor cell lines in vitro but to variable degrees of drug synergy. Compared with nontransformed MCF10A cells, the addition of both drugs resulted in stronger synergistic effects in a subset of tumor cell lines that were not predicted by breast cancer subtype. In xenograft models, GDC-0941 enhanced the antitumor activity of docetaxel with maximum combination efficacy observed within 1 hour of administering both drugs. GDC0941 increased the rate of apoptosis in cells arrested in mitosis upon cotreatment with docetaxel. Conclusion: GDC-0941 augments the efficacy of docetaxel by increasing drug-induced apoptosis in breast cancer models. Clin Cancer Res; 18(14); 3901–11. 2012 AACR.
Sequential Inference of Hospitalization ElectronicHealth Records Using Probabilistic Models

In the dynamic hospital setting, decision support can be a valuable tool for improving patient outcomes. Data-driven inference of future outcomes is challenging in this dynamic setting, where long sequences such as laboratory tests and medications are updated frequently. This is due in part to heterogeneity of data types and mixed-sequence types contained in variable length sequences. In this work we design a probabilistic unsupervised model for multiple arbitrary-length sequences contained in hospitalization Electronic Health Record (EHR) data. The model uses a latent variable structure and captures complex relationships between medications, diagnoses, laboratory tests, neurological assessments, and medications. It can be trained on original data, without requiring any lossy transformations or time binning. Inference algorithms are derived that use partial data to infer properties of the complete sequences, including their length and presence of specific values. We train this model on data from subjects receiving medical care in the Kaiser Permanente Northern California integrated healthcare delivery system. The results are evaluated against held-out data for predicting the length of sequences and presence of Intensive Care Unit (ICU) in hospitalization bed sequences. Our method outperforms a baseline approach, showing that in these experiments the trained model captures information in the sequences that is informative of their future values.
Cloning and chromosomal mapping of URA3 genes of Pichia farinosa and P. sorbitophila encoding orotidine‐5′‐phosphate decarboxylase

The PfURA3 gene, which encodes orotidine‐5′‐phosphate decarboxylase, of osmotolerant yeast Pichia farinosa NFRI 3621, was cloned by complementation of the ura3 mutation of Saccharomyces cerevisiae. The nucleotide sequence of the PfURA3 gene and its deduced amino acid sequence indicated that the gene encodes a protein (PfUra3p) of 267 amino acids. Pulsed‐field gel electrophoresis and subsequent Southern blot analysis showed that the genome of P. farinosa NFRI 3621 consisted of seven chromosomes, each approximately 1.1–2.2 Mb in size (11.8 Mb in total) and that PfURA3 was located on chromosome V. Pichia sorbitophila is considered as a synonym of P. farinosa. The genome of P. sorbitophila IFO10021 may consist of 12 chromosomes, each approximately 1.2–2.2 Mb in size. P. sorbitophila has two copies of URA3 genes, termed PsURA3 and PsURA30, which were located on chromosome VIII and III, respectively. The difference between PfURA3 and PsURA3 was only two amino acid substitutions, whereas that between PsURA3 and PsURA30 was six amino acid substitutions and the deletion of the C‐terminal amino acid by a stop codon insertion. The sequences of PfURA3, PsURA3 and PsURA30 have been deposited in the DDBJ data library under Accession Nos AB071417, AB109042 and AB109043, respectively. Copyright © 2003 John Wiley & Sons, Ltd.
Abuses of Factor Scores

A variant of the method of principal components analysis, which is due to Hotelling (1933), is currently perhaps the most popular choice for analyzing a group of variables into "factors. " The practitioner often refers to components analysis as "factor analysis with l's in the diagonal. " Kaiser's suggestion (1960; 1964) to retain only the same number of factors as there are latent roots greater than one of the matrix, R, of intercorrelations among the variables has gained wide acceptance. In a large percentage of analyses performed today called "factor analysis," Kaiser's rule for selecting the number of factors to retain after the resolution of R into principal components is used, then these are rotated orthogonally by means of Kaiser's varimax procedure (Kaiser, 1958). Not all factor analysis experts would agree that the truth is thus revealed, but few of them object to this procedure on the grounds that it lacks good psychometric and statistical justification. However, the techniques often used by researchers to calculate "factor scores" as the final step in the analysis have the blessings of no factor analysis specialists. Many researchers operate under the misapprehension that following a components-type factor analysis scores on a factor are obtained by weighting scores on variables by the loadings of the variables on the rotated factor, or that scores on a factor are obtained by summing the scores on the variables which have "high" (in absolute value) loadings on the factor. As an illustration of these two procedures, suppose that four variables have the following loadings on a varimax rotated factor:
The use of ChatGPT in higher education: The advantages and disadvantages

Higher education scholars are interested in an artificial intelligence (AI) technology called ChatGPT, which was developed by OpenAI. Whether ChatGPT can improve learning is still a topic of debate among experts. This concise overview of the literature examines the application of ChatGPT in higher education to comprehend and produce high-level instruction. By examining the essential literature, this study seeks to provide a thorough assessment of the advantages and disadvantages of utilizing ChatGPT in higher education settings. But it's crucial to consider both the positive and negative elements. For this rapid review, the researcher searched Google Scholar, Scopus, and others between January 2023 and July 2023 for prior research from various publications. These studies were examined. The study found that employing ChatGPT in higher education is beneficial for a number of reasons. It can provide individualized instruction, and prompt feedback, facilitate access to learning, and promote student interaction. These benefits could improve the learning environment and make it more fun for academics and students. The cons of ChatGPT are equally present. These problems include the inability to comprehend emotions, the lack of social interaction chances, technological limitations, and the dangers of depending too much on ChatGPT for higher education. Higher education should combine ChatGPT with other teaching techniques to provide students and lecturers with a comprehensive education. However, it is crucial to consider the positives, negatives, and moral issues before adopting ChatGPT in the classroom.
Efficient Privilege De-Escalation for Ad Libraries in Mobile Apps

The proliferation of mobile apps is due in part to the advertising ecosystem which enables developers to earn revenue while providing free apps. Ad-supported apps can be developed rapidly with the availability of ad libraries. However, today? s ad libraries essentially have access to the same resources as the parent app, and this has caused signi? cant privacy concerns. In this paper, we explore ef? cient methods to de-escalate privileges for ad libraries where the resource access privileges for ad libraries can be different from that of the app logic. Our system, PEDAL, contains a novel machine classi? er for detecting ad libraries even in the presence of obfuscated code, and techniques for automatically instrumenting bytecode to effect privilege de-escalation even in the presence of privilege inheritance. We evaluate PEDAL on a large set of apps from the Google Play store and demonstrate that it has a 98% accuracy in detecting ad libraries and imposes less than 1% runtime overhead on apps.
Imaging strongly scattering media using a multiple frequency distorted Born iterative method

The distorted Born iterative (DBI) method is a powerful approach for solving the inverse scattering problem for ultrasound tomographic imaging. This method alternates between solving the inverse scattering problem for the scattering function and the forward scattering problem for the total field and the inhomogeneous Green's function. The algorithm is initialized using the basic Born inverse solution. One fundamental problem is the algorithm diverges for strongly scattering media. This is caused by the limitation of the Born assumption in estimating the initial step of the algorithm. We present a multiple frequency DBI approach to alleviate this problem, thus extending the applicability of the DBI method to the level of dealing with biological tissue. In this multiple frequency approach, a low frequency DBI-based solution, is used to initialize the algorithm at higher frequencies. The low frequency allows convergence of the algorithm to a contrast level that is close to the true level, however, with a poor spatial resolution. The high frequency improves the spatial resolution while preserving convergence because the difference between the true contrast and the initial contrast is relatively small. We present numerical simulations that demonstrate the ability of this method to reconstruct strongly scattering regions.
The concurrent validity of the self directed search in identifying chronic career indecision among vocational education students

J. Mark Conneran is an administrator in the Middlesex County Vocational and Technical High Schools, in New Jersey and is a doctoral student in Counseling Psychology at Seton Hall University. Bruce W. Hartman is a professor in the Counseling Psychology Department, College of Education, Seton Hall University, and a licensed psychologist in private practice. Address correspondence to J. Mark Conneran, MA, Seton Hall University, 400 So. Orange Ave, 102 McQuaid Hall, So. Orange, NJ 07079.
AGENTIVE VERBS OF MANNER OF MOTION IN SPANISH AND ENGLISH AS SECOND LANGUAGES

This article presents two experiments that examine the effects of the native language (L1) on the second language (L2) acquisition of argument structure. The linguistic focus is on agentive verbs of directed motion (march, walk) and change-of-state verbs (break, melt) in Spanish and English. Agentive verbs of directed motion undergo a transitivity alternation in English when there is a prepositional phrase (The captain marched the soldiers to the tents) but not in Spanish (*El capitán marchó a los soldados hasta el campamento). Two experiments are reported that examine whether Spanish and Turkish learners of English at the intermediate level undergeneralize the transitivity alternation with manner-of-motion verbs, and whether English learners of Spanish overgeneralize the alternation. In both experiments subjects performed a picture judgment task and a grammaticality judgment task. Results confirmed that the L1 constrains the acquisition of argument structure: There were overgeneralization errors with manner-of-motion verbs in the Spanish study and there were undergeneralization errors with these verbs in the English study. Learnability implications are discussed.
The selective extraction of histone fractions from deoxyribonucleoprotein.

Three methods are described for quantitative depletion of calf thymus and chicken erythrocyte chromatin of various histone fractions. All methods involve dissociation of the histone fractions in question from chromatin in the presence of the ion-exchange resin AG50W X 2 which, having strongly bound the free histones in solution, is easily removed from the chromatin. The depleted chromatins do not appear to be denatured. Method 1. In 0.45–0.65 M NaCl, 0.05 M sodium phosphate buffer pH 7.0, histone F1 is quantitatively and selectively removed from calf thymus chromatin. In 0.55–0.65 M NaCl, 0.05 M sodium phosphate buffer pH 7.0 and a limiting amount of ion-exchange resin, histone F2C is quantitatively and selectively removed from chicken erythrocyte chromatin. Histone F1 can be quantitatively and selectively removed from chicken erythrocyte chromatin by repeated extraction with 0.5 M NaCl pH 7. By further depletion with resin in 0.55–0.65 M NaCl, 0.05 M sodium phosphate buffer pH 7.0, chicken erythrocyte chromatin can be quantitatively and selectively depleted in both histones F1 and F2C. Method 2. In 0.25–0.45M NaCl, 0.05 M sodium phosphate buffer, 4 M urea pH 7.0, histones F1, F2B and F2A2 are quantitatively and selectively removed from calf thymus chromatin. Method 3. In 0.35 M NaCl, 30% ethanol, 4 M urea pH 7.0, an almost complete removal of histones F2A1 and F2A2 from calf thymus chromatin is achieved. In 0.35 M NaCl, 300% ethanol, 5–6 M urea pH 7.0, histone F3 is removed as well.
Design and user testing of a multi-paradigm query interface to an object-oriented database

This paper reports on experience obtained during the design, implementation and use of a multi-paradigm query interface to an object-oriented database. The specific system which has been developed allows equivalent data retrieval tasks to be expressed using textual, form-based and graph-based notations, and supports automatic translation of queries between these three paradigms. The motivation behind the development of such an interface is presented, as is the software architecture which supports the multi-paradigm functionality. Feedback from initial user trials with a dual-paradigm version of the system indicates that users can use it to perform complex query tasks without difficulty, that given the choice users overwhelmingly prefer the graph- based to the text-based interaction style, and that graphical visualisation of textual queries appears to aid users in query construction.