Miracle-dz/UniFAR-FTUs huggingface dataset:
Web-Based Cognitive Behavior Therapy for Depression With and Without Telephone Tracking in a National Helpline: Secondary Outcomes From a Randomized Controlled Trial

Background An earlier report indicated that callers to a telephone counseling service benefited from the addition of an evidence-based Web intervention for depression. It is not known whether the Web intervention would also lower alcohol use and stigma, or improve quality of life and knowledge of depression and its treatments. Objective To report the secondary outcomes of a trial of a Web-based cognitive behavior therapy (CBT) intervention for depression, including hazardous alcohol use, quality of life, stigma, depression literacy, and CBT literacy. Methods We recruited a sample of 155 callers to Lifeline, a national telephone counseling service in Australia, who met the criteria for moderate to high psychological distress. Participants were randomly assigned to 1 of 4 conditions: (1) Web CBT plus weekly telephone tracking, (2) Web CBT only, (3) weekly telephone tracking only, and (4) neither Web CBT nor telephone tracking. Participants were assessed at preintervention, postintervention, and 6 and 12 months postintervention. Results At postintervention, participants who completed the Web intervention either with or without telephone support had lower levels of hazardous alcohol use (without tracking: P = .008, effect size = 0.23; with tracking: P = .003, effect size = 0.26), improved quality of life (without tracking: P = .001, effect size = 0.81; with tracking: P = .009, effect size = 0.63), and improved CBT literacy (without tracking: P = .01, effect size = 0.71; with tracking: P < .001, effect size = 0.80) compared with those who did not receive the Web intervention or telephone support. Results for quality of life and CBT literacy were maintained at 6- and 12-month’s follow-up, but differences in hazardous alcohol use were not significantly different between conditions at 6 and 12 months. Although omnibus tests for depression literacy and stigma were nonsignificant, contrasts revealed that those in the Web-only condition showed significantly lower levels of stigma than participants in the control condition at postintervention. This was true for participants in the Web-only and Web plus tracking conditions at 6 months. Similarly, those in the Web-only and Web plus tracking conditions had significantly higher depression literacy at postintervention, and this was maintained in the Web-only condition at 6-months’ follow-up. No significant differences were found in depression literacy and stigma between conditions at 12 months. Conclusions Evidence-based Web interventions for depression can be effective not only in reducing depression symptoms but also in improving other health outcomes, including quality of life, hazardous alcohol use, and knowledge about effective strategies for depression self-management. Trial Registration International Standard Randomized Controlled Trial Number (ISRCTN): 93903959; http://www.controlled-trials.com/ISRCTN93903959/ (Archived by WebCite at http://www.webcitation.org/65y61nSsH)
Methodology development of warpage analysis of polymer based packaging substrate

Warpage of packaging substrate has been at issue due to thin and flexible substrate. It is occurred during manufacturing processes. Although warpage research based on thin metal film and silicon substrate was actively studied, it has difficulty about research of polymer based electronic due to its flexibility and low stiffness compared to metal and silicon substrate. We suggest a new methodology of warpage analysis to predict the warpage behavior of polymer composite substrate based bilayer specimen during temperature rising. The warpage analysis is performed in the sequence of scanning 3D surface, calculating curvature and built-in stress of film and verifying the result using FEM simulation. Two main factors of warpage behavior are built-in stress in film layer and stress induced by misfit of coefficient of thermal expansion between film and substrate. Built-in stress, arisen from built-in strain, is generated during film lay-up process such as electro-plating of copper, curing process of polymer. It is computed from the curvature at room temperature using the strain-curvature relation. Though this analysis method, the predicted curvature through temperature cycle showed good agreement with the experiment.
Optimizing quality of resilience in the cloud

Quality of Resilience (QoR) is natively connected to cloud computing to enable high-availability of services and secure access to information. QoR, in such dynamic contexts, cannot simply rely on reactive protection models, such as the primary-backup model supported by the Stream Control Transport Protocol (SCTP). Indeed, proactive mechanisms are required to enable an optimal QoR. In this paper we propose the use of multiple criteria that assess the performance of services operating in the cloud to trigger proactive resilient mechanisms. Such criteria, considering the maximization of benefits and decrease of costs, are combined through Multiple Attribute Decision Mechanisms (MADM) to optimize quality of resilience, going beyond mechanisms relying simply on network criteria. In this context, TOPSIS and MeTH are implemented to enhance data transfer services. Evaluation results, from the tests performed in the cloud environment of a Telecom Operator, demonstrate that MeTH is able to enhance high volume data transfers in comparison to TOPSIS and also to improve resilience support of SCTP, in the presence of different kinds of failures, network conditions and server loads.
UVB-irradiated T-cells undergoing apoptosis lose L-selectin by metalloprotese-mediated shedding.

PURPOSE L-selectin (CD62L) is a prerequisite for leucocyte adhesion to endothelial cells of blood vessels and consequently for transmigration. Its expression on the cell surface therefore regulates the ability of lymphocytes to enter lymph nodes, to re-enter blood vessels or to invade tissues at sites of inflammation. The aim of this study was to determine the expression of CD62L on apoptotic lymphocytes after UVB irradiation. MATERIALS AND METHODS Peripheral blood mononuclear cells (PBMC) were isolated from peripheral blood of normal healthy volunteers. Cells were stimulated with phorbol myristate acetate (PMA) and ionomycin for activation. Apoptosis in peripheral T-cells and Jurkat cells was induced by irradiation with UVB (120 mJ/cm2). In addition, T-cells or Jurkat cells were cultured for the indicated time with anti-Fas antibody CH11. The CH11-induced apoptosis was inhibited by the pan-caspase inhibitor zVAD-fmk. For detection of apoptosis, cells were analysed by cytofluorometry for morphological changes typical for apoptosis. The reliability of the apoptotic cell gate was confirmed by staining with FITC-labelled annexin-V in the presence ofpropidium iodide (PI). For FACS analysis of CD62L expression on the cell-surface immunofluorescence was performed using FITC-conjugated anti-CD62L and PE-conjugated anti-CD3 antibodies. Soluble CD62L (sCD62L) in the cell supernatants was measured by standard ELISA technique. Assays were performed in the presence and absence of metalloprotease inhibitor KB8301. RESULTS PBMC from healthy volunteers undergoing apoptosis following UVB irradiation selectively shed CD62L, whereas the expression of the lineage-specific marker CD3 showed only minor changes. Shedding was blocked by the hydroxamic acid-based metalloprotease inhibitor KB8301. When Jurkat cells were treated with the caspase inhibitor zVAD-fmk, anti-CD95 antibodies did not induce apoptosis, and the expression of CD62L remained unaltered. CONCLUSION UVB or ionizing radiation induce apoptosis in lymphocytes. The loss of CD62L is associated with apoptosis and will influence lymphocyte trafficking and, by excluding them from CD62L-mediated adhesion and tissue invasion, might contribute to the regulation of inflammation.
Determination of Heavy Metal Ions by Capillary Electrophoresis with Contactless Conductivity Detection after Field-amplified Sample Injection

A method has been developed for determining of heavy metal ions by field-amplified sample injection capillary electrophoresis with contactless conductivity detection. The effects of the 2- N -morpholinoethanesulfonic acid/histidine (MES/His) concentration in the sample matrix, the injection time and organic additives on the enrichment factor were studied. The results showed that MES/His with a low concentration in the sample matrix, an increase of the injection time and the addition of acetonitrile improved the enrichment factor. Four heavy metal ions (Zn^2+, Co^2+, Cu^2+ and Ni^2+) were dissolved in deionized water, separated in a 10 mM MES/His running buffer at pH 4.9 and detected by contactless conductivity detection. The detection sensitivity was enhanced by about three orders of magnitude with respect to the non-stacking injection mode. The limits of detection were in the range from 5 nM (Zn^2+) to 30 nM (Cu^2+). The method has been used to determine heavy metal ions in tap water.
Mutational Analysis of the Bunyamwera Orthobunyavirus Nucleocapsid Protein Gene

ABSTRACT The bunyavirus nucleocapsid protein, N, is a multifunctional protein that encapsidates each of the three negative-sense genome segments to form ribonucleoprotein complexes that are the functional templates for viral transcription and replication. In addition, N protein molecules interact with themselves to form oligomers, with the viral L (RNA polymerase) protein, with the carboxy-terminal regions of either or both of the virion glycoproteins, and probably also with host cell proteins. Bunyamwera virus (BUNV), the prototype bunyavirus, encodes an N protein of 233 amino acids in length. To learn more about the roles of individual amino acids in the different interactions of N, we performed a wide-scale mutagenic analysis of the protein, and 110 single-point mutants were obtained. When the mutants were employed in a minireplicon assay to examine their effects on viral RNA synthesis, a wide range of activities compared to those of wild-type N protein were observed; changes at nine amino acid positions resulted in severely impaired RNA synthesis. Seventy-seven mutant clones were selected for use in the bunyavirus reverse genetics system, and 57 viable recombinant viruses were recovered. The recombinant viruses displayed a range of plaque sizes and titers in cell culture (from approximately 103 to 108 PFU/ml), and a number of viruses were shown to be temperature sensitive. Different assays were applied to determine why 20 mutant N proteins could not be recovered into infectious virus. Based on these results, a preliminary domain map of the BUNV N protein is proposed.
SNP DISCOVERY: NEXT GENERATION SEQUENCING Next-generation RAD sequencing identifies thousands of SNPs for assessing hybridization between rainbow and westslope cutthroat trout

The increased numbers of genetic markers produced by genomic techniques have the potential to both identify hybrid individuals and localize chromosomal regions responding to selection and contributing to introgression. We used restriction-site-associated DNA sequencing to identify a dense set of candidate SNP loci with fixed allelic differences between introduced rainbow trout (Oncorhynchus mykiss) and native westslope cutthroat trout (Oncorhynchus clarkii lewisi). We distinguished candidate SNPs from homeologs (paralogs resulting from whole-genome duplication) by detecting excessively high observed heterozygosity and deviations from Hardy‐Weinberg proportions. We identified 2923 candidate species-specific SNPs from a single Illumina sequencing lane containing 24 barcode-labelled individuals. Published sequence data and ongoing genome sequencing of rainbow trout will allow physical mapping of SNP loci for genome-wide scans
Effective error concealment algorithm of whole frame loss for H.264 video coding standard by recursive motion vector refinement

To benefit network transmission, the bit stream of the whole frame coded by H.264 is usually grouped into a single packet. However, the error and packet loss during the transmission will result in the distortion of reconstructed video. To deal with this problem, error concealment is widely used to recover the lost frames and to prevent error propagation. In this paper, we propose an accurate motion vector refinement algorithm to further refine the well-known motion copy error concealment method and thus improve the concealed results. By using the motion vector correlation from spatial and temporal domains, a possible motion vector difference variation area has been discovered by the recursive motion vector difference examining approach in the previous frame. Afterwards, a more precise motion vector difference can be derived from the selected motion vector difference variation area. Through the help of our proposed algorithm, the refined motion vectors can be obtained and thus improve the accuracy of motion vectors derived by a motion copy error concealment algorithm. Simulation results show that our proposed algorithm can achieve better performance compared to well-known schemes.
Cavalry equipment of the Roman army in the first century A.D.

The main aim of this paper is to identify and describe the elements that went together to make up Roman military horse (or riding) harness in the first century A.D.1 Closely linked with this, however, will be a consideration of just how much the archaeological evidence can tell us about the military use of mounts.2 It is to be hoped that the present work will at least serve to generate new interest in cavalry equipment and provoke discussion about the functions of its various components.
A net advantage? The internet, grassroots activism and American Middle-Eastern policy

The uses to which social movements and other grassroots actors put the internet have gained considerable attention from researchers. Often, the internet's role in helping some activists to attain their goals has been cited as evidence that internet technology offers greater benefits to marginal interests than to those already enjoying access to mainstream political and media institutions. This article investigates the possibility that activist networks striving to alter American state policies towards Israel and Palestine will enjoy relatively greater advantages from their use of the internet than those working to uphold the political status quo. Evidence suggests that while the internet has become indispensable for the social movement organizations under consideration, it is unlikely to help them overcome the most significant barriers to influencing government policies and/or public opinion.
Top attention in line with time: A light-weight strategy

For video representation, dense sampling along trajectories or optical flow stacking are both heavy-cost computations. This paper aims to develop a light-weight strategy which could skip the computations of optical flow and trajectories. Particularly, taking frames as inputs to a pre-trained ConvNet, we extract top layers as video feature maps. Instead of trajectory pooling, we directly pooled these feature maps in line with time, which is named Line Pooling. We utilize the proposed Line-pooled Deep-convolutional Descriptors (LDDs) to weight regions with high motion saliency, which turns out to pay attention to actions in line with time. Experiments on UCF101 and HMDB51 demonstrate the efficiency, effectiveness, and promising performance of our method.
Photodetector fabrication by dielectrophoretic assembly of GaAs nanowires grown by a two-steps method

GaAs nanowires (NWs) are promising advanced materials for the development of high performance photodetectors in the visible and infrared range. In this work, we optimize the epitaxial growth of GaAs NWs compared to conventional procedures, by introducing a novel two-steps growth method that exhibits an improvement of the resulting NW aspectratio and an enhancement of the NW growth rate. Moreover, we investigate the contactless manipulation of NWs using non-uniform electric fields to assemble a single GaAs NW on conductive electrodes, resulting in assembly yields above 90%/site and an alignment yields of around 95%. The electrical characteristics of the dielectrophoretic contact formed between the NW and the electrode have been measured, observing that the use of n-type Al-doped ZnO (AZO) as electrode material for NW alignment produces Schottky barrier contacts with the GaAs NW body. Moreover, our results show the fast fabrication of diodes with rectifying characteristics due to the formation of a low-resistance contact between the Ga catalytic droplet at the tip of the NW and the AZO electrode. The current-voltage measurements of a single GaAs NW diode under different illumination conditions show a strong light responsivity of the forward bias characteristic mainly produced by a change on the series resistance.
Intrafamilial resource competition and mate competition shaped social‐group‐specific natal dispersal in the 18th and 19th century Krummhörn population

We describe the natal dispersal patterns of the Krummhörn population as the outcome of intrafamilial competition. Depending on the affiliation with a specific social group and the sex of the individual, this competition is driven by different factors and obeys a different functional logic: The dispersal patterns of the daughters of landless workers allow a mate competition scenario to be detected, whereas the dispersal behavior of the children of farmers (especially of the sons) is driven by a resource competition scenario. Am. J. Hum. Biol., 2008. © 2008 Wiley‐Liss, Inc.
Non-specific and sex-differential effects of routine vaccines: What evidence is needed to take these effects into consideration in low-income countries?

None of the original vaccines used in the child immunization programmes in low-income countries, including BCG, diphtheria-tetanus-pertussis (DTP), oral polio vaccine (OPV), and measles vaccine (MV), were tested for their overall effect on child mortality before being introduced. It was assumed that the effect on overall child mortality would be equivalent to the proportion of deaths caused by the targeted disease(s) (1). However, this is no longer a tenable assumption. Many studies have shown that these routine vaccines may have more general effects on the immune system than merely protecting against the targeted disease, i.e. so-called non-specific effects (NSE) (2). The NSE may well be more important for overall child survival than the lives saved by specific disease prevention (2-4). The WHO´s Global Advisory Committee on Vaccine Safety (GACVS) has recently stated that it will keep a watch on the non-specific effects (NSE) of vaccination. GACVS indicated that “conclusive evidence for or against non-specific effects of vaccines on mortality, including a potential deleterious effect of DTP vaccination on children’s survival as has been reported in some studies, was unlikely to be obtained from observational studies” (5). By insisting on new RCTs to provide conclusive evidence, GACVS is making it very difficult if not impossible to test the NSEs of the currently recommended vaccines. It would usually be considered unethical to test currently recommended vaccines as part of a trial withholding these vaccines from some children (6).
Energy-Efficient Transceivers for Ultra-Highspeed Computer Board-to-Board Communication

Enabling the vast computational and throughput requirements of future high performance computer systems and data centers requires innovative approaches. In this paper, we will focus on the communication between computer boards. One alternative to the bottleneck presented by copper wire based cable-bound communication is the deployment of wireless links between nodes consisting of processors and memory on different boards in a system. In this paper, we present an interdisciplinary approach that targets an integrated wireless transceiver for short-range ultra-high speed computer board-to-board communication. Based on our achieved results and current developments, we will also estimate energy consumption of such a transceiver.
Biodistribution and pharmacokinetics of 125I‐labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma

Carbonic anhydrase IX (CA IX) is frequently expressed in human carcinomas and absent from the corresponding normal tissues. Strong induction by tumor hypoxia predisposes CA IX to serve as a target for cancer diagnostics and therapy. Here we evaluated targeting properties and pharmacokinetics of CA IX‐specific monoclonal antibody (MAb) M75. Binding parameters of 125I‐labeled M75, including equilibrium dissociation constant, hypoxia‐related binding to various cell lines and internalization, were analyzed in vitro. Biodistribution of 125I‐M75 in nude mice bearing HT‐29 human colorectal carcinoma xenografts with hypoxic pattern of CA IX expression was studied by measurements of radioactivity in dissected tissues and macroautoradiography of tissue sections. Pharmacokinetics of intravenously administered 125I‐M75 was described using a 2‐compartment model. Blood clearance showed a distribution phase t1/2(α) = 3.4 hr and an elimination phase t1/2(β) = 55.3 hr postinjection. Despite predominant CA IX localization in less accessible perinecrotic regions, 125I‐M75 exhibited specific accumulation in xenograft, with a mean uptake of 15.3 ± 3.6% of injected dose per gram of tumor tissue at 48 hr postadministration. Specificity of M75 localization was confirmed by low tumor uptake of control antibody. Altogether, our data demonstrate that M75 MAb is a promising tool for selective immunotargeting of hypoxic human tumors that express CA IX. © 2003 Wiley‐Liss, Inc.
On the use of Unified And-Or fuzzy aggregation operator for multi-criteria decision making in wind farm design process using wind turbines in 500 kW – 750 kW range

In recent years, wind energy has become an important field of study. A major focus of this study is the efficient design of wind farms. This design process involves consideration of a number of design criteria, which are often conflicting. Therefore, a balanced solution needs to be found that provides the best tradeoff between all design criteria. In this paper, a fuzzy logic based decision making approach is proposed to address the multi-criteria aspects of the problem which requires finding the optimum combination of two important design criteria, namely, hub height and zero output percentage. Using the Unified And-Or (UAO) aggregation operator, a mechanism is modelled and formulated to achieve the best tradeoff between the two design criteria. Results reveal the effectiveness of the proposed approach in addressing the issue of finding the optimal combination values for the hub height and zero output percentage.
MPC for tracking periodic reference signals

This paper is devoted to the design of a predictive controller for constrained linear systems to track periodic references. The only assumption on the dynamics of the reference is that it is periodic and its period is known. It is also assumed that the reference signal is a priori known by the controller. Inspired in the hierarchical control scheme based on the trajectory planification, the ideas of the MPC for tracking [Limon et al., 2008] are extended to this case. The proposed predictive controller has the future sequence of inputs and an artificial reference as decision variables. The cost function is divided into two terms: one penalizes the tracking error with the artificial reference and other penalizes the deviation of the artificial reference to the reference to be tracked. Stability is ensured thanks to the addition of two constraints: a terminal constraint on the predicted trajectory and a constraint that enforces the artificial reference to be periodic. It is proved that the proposed controller is recursively feasible and the controlled system satisfies the hard constraints, is asymptotically stable and converges to the best possible reachable trajectory. The properties of the proposed controller are illustrated in an example.