Miracle-dz/UniFAR-FTUs huggingface dataset:
[Gilbert's syndrome in children--our experience].

INTRODUCTION Gilbert's syndrome represents the most frequent hereditary disorder of bilirubin metabolism. It occurs in 2-7% of subjects in general population, and is manifested by mild unconjugated hyperbilirubinaemia of benign nature. OBJECTIVE The study was conducted in order to analyse our experience related to the circumstances of disclosure, age at onset and sex distribution of Gilbert's syndrome in children. METHOD The diagnosis of Gilbert's syndrome was based on the findings of mild unconjugated hyperbilirubinaemia in the absence of haemolysis and organic liver disease, as well as significant increase of bilirubin unconjugated fraction in serum after a 3-day hypocaloric diet (400 kcal/daily). RESULTS Of 58 subjects with Gilbert's syndrome, there were 40 (68.97%) boys and 18 (31.03%) girls, indicating a 2.22 fold higher incidence of boys than girls. The age at diagnosis of the disorder was similar in boys and girls, and was 12.2-18 (X =14.71 +/- 1.55) years for boys and 10.5-16.4 (X = 14.38 +/- 2.10) years for girls (p > 0.05). Except for 3 girls aged below 12 years, in all other patients the diagnosis was made after that age; in 20, between age 12 and 14 years and in 14, between age 14 and 16 years, while in 10 patents, it was made at age between 16 and 18 years. In 20 (34.48%) subjects, hyperbilirubinaemia was disclosed on routine paediatric examination, in 19 (32.76%) when differentiating the cause of recurrent or acute abdominal pain, in 17 (29.3%) during febrile condition and in 2 during insufficient caloric intake. The values of unconjugated bilirubinaemia, both before a hypocaloric test and after a 3-day energy deprivation, were higher in boys than girls, but this difference was statistically significant only after the 3-day hypocaloric diet in age group between 16 and 18 years (p = 0.038). Also, no significant difference was found in bilirubinaemia level between the different age groups either in boys or girls. CONCLUSION According to our findings, in children, Gilbert's syndrome is manifested only in puberty, and 2.22 times more often in boys than girls. It is most frequently revealed during a routine paediatric examination, as well as when investigating the cause of abdominal pain and fever. A significantly higher level of serum bilirubin in boys as related to girls is registered only after a hypocaloric diet in age group between 16 and 18 years.
Evaluation of subsampling and fixation procedures used for counting rumen protozoa

Total numbers of protozoa can be significantly lower in rumen fluid than in whole rumen contents, depending on the time of sampling and the procedure used to separate the fluid and solid fractions. Moreover, generic distribution in rumen fluid was significantly affected in all cases tested. The percentage of Entodinium spp. increased, whereas percentages of Diplodinium spp. and Ophryoscolex spp. decreased. Microscopic observation of fresh and fixed rumen contents did not indicate any marked attachment of protozoa to particulate matter. In addition, dilution of whole rumen contents with water, 5 mM sucrose, or 0.1% Tween 80 before fixation did not affect total numbers or generic composition of protozoa. It was thus concluded that attachment to feed particles is probably not a problem in counting procedures. Blending of whole rumen contents to facilitate subsampling caused a decrease in numbers of protozoa. The concentration of formaldehyde used for preservation of rumen contents, 4, 10, or 18.5%, did not affect the total count.
Alzheimer disease‐like clinical phenotype in a family with FTDP‐17 caused by a MAPT R406W mutation

We report clinical, molecular, neuroimaging and neuropathological features of a Danish family with autosomal dominant inherited dementia, a clinical phenotype resembling Alzheimer’s disease and a pathogenic mutation (R406W) in the microtubule associated protein tau (MAPT) gene. Pre‐symptomatic and affected family members underwent multidisciplinary (clinical, molecular, neuroimaging and neuropathological) examinations. Treatment with memantine in a family member with early symptoms, based on the clinical phenotype and the lack of specific treatment, appears to stabilize the disease course and increase the glucose metabolism in cortical and subcortical areas, as determined by serial [F18]FDG‐PET scanning before and after initiation of treatment. Neuropathological examination of a second affected and mutation‐positive family member showed moderate atrophy of the temporal lobes including the hippocampi. Microscopy revealed abundant numbers of tau‐positive neurofibrillary tangles in all cortical areas and in some brainstem nuclei corresponding to a diagnosis of frontotemporal lobe degeneration on the basis of a MAPT mutation. The clinical and genetic heterogeneity of autosomal dominant inherited dementia must be taken into account in the genetic counselling and genetic testing of families with autosomal dominantly inherited dementia in general.
{4-Chloro-N′-[(2-oxidonaphthalen-1-yl-κO)methylidene]benzohydrazidato-κ2 N′,O}dimethyltin(IV)

In the title complex, [Sn(CH3)2(C18H11ClN2O2)], the SnIV ion is coordinated by two O atoms and an N atom from a 4-chloro-N′-[(2-oxidonaphthalen-1-yl)methylidene]benzohydrazidate ligand and two C atoms from two methyl ligands in a distorted trigonal–bipyramidal geometry [Sn—O = 2.092 (3) and 2.144 (3) Å; Sn—N = 2.160 (4) Å]. The dihedral angle between the naphthalene ring system and the benzene ring is 8.6 (2)°. In the crystal, adjacent molecules are linked by weak C—H⋯O hydrogen bonds, forming a chain along the b-axis direction.
Multiple sclerosis patients with and without sexual dysfunction: are there any differences?

Objective Sexual dysfunction (SD) severely affects the quality of life in patients with multiple sclerosis (MS). The aim of this study is to investigate the type and frequency of sexual complaints in MS patients, to analyse their relationship to various clinical and psychosocial variables and to clarify the differences between MS patients with and without SD. Methods Thirty-five relapsing-remitting (RR), nine secondary progressive and seven primary progressive MS patients were included in this study. A structured face-to-face interview regarding sexual function and other physical problems which may interfere with sexual functioning was administered to each patient. They also filled out Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19), which includes items for primary (direct physical), secondary (indirect physical) and tertiary (psychosocial) causes of SD. Disability, cognitive functions and psychological functioning were also evaluated. Results Forty-one patients (80.4%) reported primary SD; decreased libido was the most frequent complaint (80.5%). These patients were older and more disabled, however 39% had low disability scores. SD was a common problem for both men and women. Patients with RRMS were affected less in all items of primary SD. Several items of secondary SD-problems with memory and concentration, bladder symptoms, bowel symptoms-showed correlation with different items of primary SD; these were altered genital sensation, decreased libido, increased time for arousal, decreased lubrication/difficulties with erection. Total MSISQ-19 scores were correlated with disease duration, age, disability, disease course, Beck depression scale, temporary and long-standing anxiety and low level of education. Conclusion SD is an underestimated, common symptom of MS. It may occur in MS even in the absence of severe disability. Physicians’ awareness of this problem may help to bring about appropriate treatments and management, and improve the quality of life for these patients.
Identities in Practice: A Trans-Atlantic Ethnography of Sikh Immigrants in Finland and in California

REVIEWS I One cannot deny the fervor and passion with which Gill engages in dance: Dancing and studying dancing have revealed to me hints about how to compre- hend the amazing profundity and complexity of dancing. My feelings about dancing are those of a new religious convert. I see dancing as at the core of what constitutes us as human beings. I believe dancing to be the realization of human potential. I be- lieve that dancing has the potential to offer new paradigms for the study of culture and religion (193) . In his final chapter, Dancing, Gill demonstrates the multiple ways in which dance engages with religion, his field of study, and how other schol- ars might profit from studying dance and dancing. The importance of this book for dance scholars is that it engages with dance from outside the field, and Gill amply demonstrates this with his engagement with his own field of religion and the mul- tiple ways in which dance intersects with religious practices, even embodying them. He states, Since dancing is often intimately connected with religion, even with traditions that forbid it, there is much promise for religion and dance studies (55). His ~tudy demonstrates the multiple ways in which scholars outside of the field can profit by the use of the works of dance scholars. Food for thought. REFERENCES DESMOND, Jane c. Embodying differences: Issues in dance and cultural studies. In Meaning in Motion, ed. Jane C. Desmond, 29-54· Durham and London: Duke University Press. FISHER, Jennifer, and Anthony SHAY, eds. 2008 When Men Dance: Dancing Across Borders of Masculinities. NY: Oxford Uni- versity Press. ROYCE, Anya Peterson Anthropology of Dance. Bloomington: Indiana University Press. Anthony Shay Pomona College Laura Hirvi, Identities in Practice: A Trans-Atlantic Eth11og1·aphy of Sikh Immigrants in Fi nland and in California Helsinki: SKS, 2013. r85 pages. Glossary, appendices, references, index. Paperback, (44.00. ISBN 978-952-222-470-5. LAURA HIRVI's comparative (she prefers contrastive) ethnography of Sikh immigrants in Finland and California is an impressive work. She conducted fieldwork at two sites, Helsinki in Finland and Yuba City in California, both the densest Sikh settlements in these countries. Hirvi's study of the Helsinki Sikhs is the first such study, while for Yuba City she builds on several earlier studies. The numbers, timing, and family and
Perceived significance of information security governance to predict the information security service quality in software service industry: An empirical analysis

Purpose – Information security is a growing concern in society, across businesses and government. As the offshore IT services market continues to grow providing numerous benefits, there are also perceived risks with respect to the quality of information security delivered in the supply chain. This paper aims to examine, as a case, the perceptions of Indian software services provider (service provider) employees with respect to information security governance and its impact on information security service quality that is delivered to customers. Design/methodology/approach – The paper provides a framework built upon the existing dimensions and instruments for total quality management and service quality, suitably modified to reflect the context of information security. SmartPLS, a structural equation modelling technique, has been used to analyse field survey data collected from across various Indian cities and companies. Findings – Significant finding is that information security governance in an IT outsour.
Yes-associated protein is not an independent prognostic marker in breast cancer.

BACKGROUND The development of tissue microarray (TMA) technology has provided the opportunity to perform analyses of tissue samples on a large scale in an uniform fashion. This study was designed with the use of TMA to explore the Yes-associated protein (YAP) status in breast cancer. PATIENTS AND METHODS YAP expression in tumor and tumor-free samples from 94 patients with primary breast cancer was analyzed by TMA. The clinicopathological data for age, estrogen receptor status, histological grading and TNM staging were also collected. RESULTS There were 29 patients (30.8%) with 1(+) expression, in YAP, 59 patients (62.8%) with 2(+) expression and 6 (6.4%) with 3(+) expression. There was no significant relationship between YAP expression and the other clinicopathological variables. By multivariate analysis, YAP expression failed to produce any significant relationship with the overall survival rate. CONCLUSION YAP expression is not an independent prognostic factor in patients with breast cancer.
TGF- b SIGNALING PATHWAY: ITS ROLE IN GASTROINTESTINAL PATHOPHYSIOLOGY AND MODULATION OF ULCER HEALING

Gastrointestinal ulcer healing is a complex process, involving cell migration, proliferation, angiogenesis and extracellular matrix deposition, all ultimately leading to reconstruction of tissue architecture within the ulcer scar. These processes are controlled by growth factors, cytokines and hormones. Transforming growth factor-b (TGF- b ), one of the multifunctional peptide growth factors, has been reported to positively regulate gastrointestinal ulcer healing. Although TGF- b inhibits cell proliferation in a variety of cells, it induces cell migration, angiogenesis, and enhances extracellular matrix production necessary for gastrointestinal ulcer healing. TGF- b exerts its action by binding to its transmembrane serine/threonine kinase receptors, which in turn triggers activation of various intracellular signaling pathways. Smads are intermediate effector proteins that play key roles in biological activities of TGF- b by transmitting the signals from the cell surface directly into the nucleus and initiating transcription. New insight into the mechanisms underlying TGF- b -Smad modulation of gastrointestinal ulcer healing will likely enhance our understanding of the mechanisms controlling the healing processes of gastrointestinal ulcers.
Spectral approach for kernel-based interpolation

We describe how the resolution of a kernel-based interpolation problem can be associated with a spectral problem. An integral operator is defined from the embedding of the considered Hilbert subspace into an auxiliary Hilbert space of square-integrable functions. We finally obtain a spectral representation of the interpolating elements which allows their approximation by spectral truncation. As an illustration, we show how this approach can be used to enforce boundary conditions in kernel-based interpolation models and in what it offers an interesting alternative for dimension reduction.
Medetomidine-ketamine anesthesia in red-eared slider turtles (Trachemys scripta elegans).

This study evaluated the effects of high and low dosages of medetomidine-ketamine in red-eared slider turtles (Trachemys scripta elegans) and the reversibility of the anesthesia with atipamezole. Thirty healthy adult turtles were assigned randomly to one of two dosage groups. The lower dosage group received 0.1 mg medetomidine/kg body weight intramuscularly (i.m.) combined with 5 mg ketamine/kg i.m. The higher dosage group received 0.2 mg medetomidine/kg i.m. combined with 10 mg ketamine/kg i.m. Physiologic parameters evaluated included heart rate, palpebral reflex, limb and neck relaxation, and cloacal temperature. Responses to minor procedures such as i.m. injection (0.1 ml 0.9% NaCl) and endotracheal intubation also were evaluated. In addition, the higher dosage group was evaluated for responsiveness to a skin incision and placement of a skin suture. Both dosage trials resulted in a level of anesthesia deep enough for performing a physical examination, minor procedures, and endotracheal intubation. The higher dosage produced a level of anesthesia sufficient for performing a skin incision and suture placement. Heart rate and cloacal temperatures remained stable throughout the entire procedure for both groups. Atipamezole was administered i.m. at five times the dose of medetomidine (0.5 mg/kg i.m. or 1 mg/kg i.m.) 60 min after the medetomidine-ketamine was administered. All of the turtles were swimming 60 min after atipamezole administration.
OBSERVATIONS OF MASS LOSS FROM THE TRANSITING EXOPLANET HD 209458b

Using the new Cosmic Origins Spectrograph on the Hubble Space Telescope, we obtained moderate-resolution, high signal/noise ultraviolet spectra of HD 209458 and its exoplanet HD 209458b during transit, both orbital quadratures, and secondary eclipse. We compare transit spectra with spectra obtained at non-transit phases to identify spectral features due to the exoplanet's expanding atmosphere. We find that the mean flux decreased by 7.8% ± 1.3% for the C ii 1334.5323 Å and 1335.6854 Å lines and by 8.2% ± 1.4% for the Si iii 1206.500 Å line during transit compared to non-transit times in the velocity interval −50 to +50 km s−1. Comparison of the C ii and Si iii line depths and transit/non-transit line ratios shows deeper absorption features near −10 and +15 km s−1 and less certain features near −40 and +30–70 km s−1, but future observations are needed to verify this first detection of velocity structure in the expanding atmosphere of an exoplanet. Our results for the C ii lines and the non-detection of Si iv 1394.76 Å absorption are in agreement with Vidal-Madjar et al., but we find absorption during transit in the Si iii line contrary to the earlier result. The 8% ± 1% obscuration of the star during transit is far larger than the 1.5% obscuration by the exoplanet's disk. Absorption during transit at velocities between −50 and +50 km s−1 in the C ii and Si iii lines requires high-velocity ion absorbers. Assuming hydrodynamic model values for the gas temperature and outflow velocity at the limb of the outflow as seen in the C ii lines, we find mass-loss rates in the range (8–40)×1010 g s−1. These rates assume that the carbon abundance is solar, which is not the case for the giant planets in the solar system. Our mass-loss rate estimate is consistent with theoretical hydrodynamic models that include metals in the outflowing gas.
Efficient IR drop analysis and alleviation methodologies using dual threshold voltages with gate resizing techniques

IR drop impacts circuit delay time and reliability. The IR drop comes from unexpected peak current (Ipeak) consumption. This paper proposes an efficient methodology with in-house EDA tools named IPR to analyze and reduce the Ipeak. IPR adopts dual threshold voltages (Vth) and gate resizing techniques, lowers the short, dynamic and static leakage current consumption without degrading system performance. IPR consists of two parts, i.e. Ipeak analysis and Ipeak alleviation processes. Nonlinear static/dynamic timing analysis techniques in cooperation with dual Vth cell library provide two kinds of accurate Ipeak calculation methods used in IPR. Using the incremental timing analysis, the Ipeak processing time can be accelerated. Demonstration of the ISCAS89 benchmark circuits shows that IPR can reduce Ipeak by 39%, power consumption by 14%, and delay time by 19%. In addition, it provides 334 times faster computation with 2% and 10% estimation errors of the Ipeak and power in gate level, respectively as compared to circuit level simulation results.
The Relation of Personality Characteristics to Body Image Disturbances in Juvenile Anorexia Nervosa: A Multivariate Analysis

&NA; The relationship between Minnesota Multiphasic Personality Inventory (MMPI) factors and two separate measures of body image‐estimation of body size and subjective report of distorted bodily experiences‐was investigated using multivariate analyses in adolescent females with anorexia nervosa. A canonical correlational analysis of these data indicated the presence of two orthogonal dimensions defining the relation between personality and body image scores. In the first canonical variate, size overestimation and subjective body image distortion were both associated with MMPI scales reflecting somatization, anxiety, and atypical thinking; in the second variate, size overestimation alone was found to be associated with introversion and depression, while subjective body image distortion aligned with somatization and atypical thinking. The results suggest that different measures of body image disturbance are associated with different personality characteristics. Results are discussed in terms of the importance of personality factors in the pathogenesis of body image disturbances in anorexia nervosa.
Statistical Prediction of the Type of Gastric Aspiration Lung Injury Based on Early Cytokine/Chemokine Profiles

Background:Unwitnessed gastric aspiration can be a diagnostic dilemma, and early discrimination of different forms may help to identify individuals with increased risk of development of severe clinical acute lung injury or acute respiratory distress syndrome. The authors hypothesized that inflammatory mediator profiles could be used to help diagnose different types of gastric aspiration. Methods:Diagnostic modeling using a newly modified receiver operator characteristic approach was applied to recently published data from our laboratory on lavaged inflammatory mediators from rodents given intratracheal normal saline, hydrochloric acid, small nonacidified gastric particles, or a combination of acid and small gastric particles. Multiple animal groups and postaspiration times of injury were analyzed to gauge the applicability of the predictive approach: rats (6 and 24 h), C57/BL6 wild-type mice (5 and 24 h), and transgenic mice on the same background deficient in the gene for monocyte chemoattractant protein 1 (MCP-1 [−/−] mice; 5 and 24 h). Results:Overall, the four types of aspiration were correctly discriminated in 85 of 96 rats (89%), 72 of 78 wild-type mice (92%), and 59 of 73 MCP-1 (−/−) mice (81%) by models that used a maximum of only two mediators. The severe “two-hit” aspirate of the combination of acid and small gastric particles was correctly predicted in 21 of 24 rats, 23 of 23 wild-type mice, and 21 of 21 MCP-1 (−/−) mice. Specific best-fit mediators or mediator pairs varied with aspirate type, animal type, and time of injury. Cytokines and chemokines that best predicted the combination of acid and small gastric particles were cytokine-induced neutrophil chemoattractant 1 (6 h) and MCP-1 (24 h) in rats, tumor necrosis factor α/macrophage inflammatory protein 2 (5 h) and tumor necrosis factor α/MCP-1 (24 h) in wild-type mice, and tumor necrosis factor α/macrophage inflammatory protein 2 (5 h) and tumor necrosis factor α/keratinocyte-derived cytokine (24 h) in MCP-1 (−/−) mice. Conclusions:These results support the potential feasibility of developing predictive models that use focused measurements of inflammatory mediators to help diagnose severe clinical forms of unwitnessed gastric aspiration, such as the combination of acid and small gastric particles, that may have a high risk of progression to acute lung injury/acute respiratory distress syndrome.
Rumination as a Marker of Psychological Improvement in Transsexual Women Postoperative

Abstract Purpose: This study aimed to analyze rumination levels of transsexual women before and after gender affirmation surgery (GAS). Rumination scores may represent a broader measure of GAS success and an alternative to patient-reported satisfaction, quality of life, well-being, or the presence of “caseness” for anxiety or depression as previously established in the literature. Methods: Thirty-nine transsexual women were recruited. The participants completed the rumination scale of the Response Styles Questionnaire (RSQ) and were divided into three subsets according to the treatment time. Results: The rumination scores were lower in the transsexual women who had undergone surgical procedures on primary sexual characteristics and gradually decreased with each additional procedure completed with respect to secondary sexual characteristics. Conclusion: Rumination appears to comprise an important marker of improvement in post-GAS transsexual women.