Miracle-dz/UniFAR-FTUs huggingface dataset:
Abstract—in This Paper a Novel Approach for Evaluating

features is proposed, along with its applications in the diagnosis of faults. As most existing methods for this task make use of a number of assumptions about the features, their evaluations may not always be very reliable. The proposed methodology aims to address this issue. In this paper three distinct metrics based on an assumption-free framework have been developed and presented, along with a GUI to facilitate their use. The features assessed are based on a real world dataset from a project the authors are involved in. The results of the analysis conducted appear to be promising.
Mutational screening of VSX1, SPARC, SOD1, LOX, and TIMP3 in keratoconus

Purpose To evaluate the involvement of Visual System Homeobox 1 (VSX1), Secreted Protein Acidic and Rich in Cysteine (SPARC), Superoxide Dismutase 1 (SOD1), Lysyl Oxidase (LOX), and Tissue Inhibitor of Metalloproteinase 3 (TIMP3) in sporadic and familial keratoconus. Methods Mutational analysis of the five genes was performed by sequencing and fragment analysis in a large cohort of 302 Italian patients, with a diagnosis of keratoconus based on clinical examination and corneal topography. The variants identified in VSX1 and SPARC were also assessed in the available relatives of the probands. Results A novel mutation p.G239R and previously reported mutations were found in VSX1. Novel and already reported variants were identified in SPARC and SOD1, whose pathogenic significance has not been established. No pathogenic variants have been identified in LOX and TIMP3. Conclusions Molecular analysis of the five genes in a cohort of 225 sporadic and 77 familial keratoconus cases confirms the possible pathogenic role of VSX1 though in a small number of patients; a possible involvement of LOX and TIMP3 could be excluded; and the role played by SOD1 and SPARC in determining the disease as not been definitively clarified. Further studies are required to identify other important genetic factors involved in the pathogenesis and progression of the disease that in the authors’ opinion, and according with several authors, should be considered as a complex disease.
A mutation in human immunodeficiency virus type 1 protease at position 88, located outside the active site, confers resistance to the hydroxyethylurea inhibitor SC-55389A

The hydroxyethylurea human immunodeficiency virus type 1 (HIV-1) protease inhibitors SC-55389A and SC-52151 were used to select drug-resistant variants in vitro. One clinical HIV-1 strain (89-959) and one laboratory HIV-1 strain (LAI) were passaged in peripheral blood mononuclear cells or CEMT4 cells in the presence of SC-55389A. Resistant isolates from both strains consistently had a mutation to serine for asparagine at amino acid 88 (N88S) in the protease gene either alone or in combination with a change to phenylalanine at position 10. The N88S mutation, recreated by oligonucleotide-mediated site-directed mutagenesis in HXB2, was sufficient to confer resistance to SC-55389A. In contrast, SC-52151-resistant variants selected from the monocytotropic strain SF162 had multiple substitutions in the protease gene (I11V, M461, F53L, A71V, and N88D), and the N88D mutation, re-created by oligonucleotide-mediated site-directed mutagenesis in HXB2, did not confer resistance to SC-52151. The potencies of L735,524 and Ro31-8959 were not reduced when these compounds were assayed against variants with either the N88S or N88D substitution. Position 88 is in a helix that lies behind the substrate binding pocket and may indirectly influence inhibitor binding through interactions with the amino acid at position 31. The selected mutations were persistent in the viral populations after more than 20 passages in the absence of drugs. Passaging of virus first in SC-55389A alone and then in combination with SC-52151 resulted in the accumulation of more mutations in the protease gene (L10F, D35E, D37M, I47V, 154L, A71V, V82I, and S88D) and in the selection of a variant that was cross-resistant to multiple protease inhibitors. These results indicate that a mutation in the HIV-1 protease at a position that is located outside of the substrate binding pocket confers resistance to a protease inhibitor and that mutations in the protease gene accumulate with increasing selection pressure and can persist in the absence of selection pressure.
Percolate or die: Multi-percolation decides the struggle between competing innovations

Competition is one of the most fundamental phenomena in physics, biology and economics. Recent studies of the competition between innovations have highlighted the influence of switching costs and interaction networks, but the problem is still puzzling. We introduce a model that reveals a novel multi-percolation process, which governs the struggle of innovations trying to penetrate a market. We find that innovations thrive as long as they percolate in a population, and one becomes dominant when it is the only one that percolates. Besides offering a theoretical framework to understand the diffusion of competing innovations in social networks, our results are also relevant to model other problems such as opinion formation, political polarization, survival of languages and the spread of health behavior.
Plant-Based Microarray Data at the European Bioinformatics Institute. Introducing AtMIAMExpress, a Submission Tool for Arabidopsis Gene Expression Data to ArrayExpress

ArrayExpress is a public microarray repository founded on the Minimum Information About a Microarray Experiment (MIAME) principles that stores MIAME-compliant gene expression data. Plant-based data sets represent approximately one-quarter of the experiments in ArrayExpress. The majority are based on Arabidopsis (Arabidopsis thaliana); however, there are other data sets based on Triticum aestivum, Hordeum vulgare, and Populus subsp. AtMIAMExpress is an open-source Web-based software application for the submission of Arabidopsis-based microarray data to ArrayExpress. AtMIAMExpress exports data in MAGE-ML format for upload to any MAGE-ML-compliant application, such as J-Express and ArrayExpress. It was designed as a tool for users with minimal bioinformatics expertise, has comprehensive help and user support, and represents a simple solution to meeting the MIAME guidelines for the Arabidopsis community. Plant data are queryable both in ArrayExpress and in the Data Warehouse databases, which support queries based on gene-centric and sample-centric annotation. The AtMIAMExpress submission tool is available at http://www.ebi.ac.uk/at-miamexpress/. The software is open source and is available from http://sourceforge.net/projects/miamexpress/. For information, contact miamexpress@ebi.ac.uk.
Intrusion Prevention in Information Systems: Reactive and Proactive Responses

Intrusion prevention requires effective identification of and response to malicious events. In this paper, we model two important managerial decisions involved in the intrusion prevention process: the configuration of the detection component, and the response by the reaction component. The configuration decision affects the number of alarms the firm has to investigate. It is well known that the traditional intrusion detection system generates too many false alarms. The response decision determines whether alarms are going to be investigated or rejected outright. By jointly optimizing these two decision variables, a firm may apply different strategies in protecting its informational assets: slow but accurate, rapid but inaccurate, or a mixture of the two strategies. We use the optimal control approach to study the problem. Unlike previous literature, which studied the problem with a static model, in our model, the decision on balancing the desire to detect all malicious events with the opportunity costs required to do so is time dependent. Furthermore, we show how the choice of an optimal mixture of reactive and proactive responses depends on the values of cost parameters and investigation rate parameters. We find that in our model, a high damage cost does not immediately translate to a preference of proactive response, or a high false rejection cost does not translate to a preference of reactive response. The dynamics of the problem, such as how fast alarms accumulate and how fast they can be cleared, also affect the decisions.
Specific gravity and creatinine as corrections for variation in urine concentration in humans, gorillas, and woolly monkeys

Hormones excreted in the urine are widely used to assess the physiological and psychological condition of unrestrained animals. In order to control for variation in the water concentration of urine samples, the hormone concentration is often indexed to the concentration of creatinine. Because there are several problems with using creatinine, we have investigated the efficacy of specific gravity as an alternative basis for adjusting the hormone concentration in humans, gorillas, and woolly monkeys. In an experimental manipulation of human urine hydration, ten volunteers drank a water load proportional to body weight, and provided complete urine collection and saliva samples for four consecutive 20 min intervals. From the urine, we measured cortisol (radioimmunoassay), creatinine (colorimetric assay), and specific gravity (refractometer). Only cortisol was assayed from saliva. During 80 min following water ingestion, cortisol, creatinine, and specific gravity declined as urine became diluted; however, total cortisol excretion remained constant. Only cortisol concentration indexed to specific gravity accurately reflected the consistent cortisol excretion. Specific gravity and creatinine‐corrected cortisol values were highly correlated but were significantly different. Salivary cortisol provided evidence for the relative stability of serum cortisol. To determine the utility of these corrections in other primates, we compared specific gravity‐ and creatinine‐corrected cortisol in urine samples from captive gorillas (N=16) and woolly monkeys (N=8). As with the human study, the two corrections were strongly correlated in each species, but the means were different. Specific gravity correction was superior in revealing the circadian variation in cortisol. Am. J. Primatol. 72:1082–1091, 2010. © 2010 Wiley‐Liss, Inc.
Using the Web for Associative Anaphora Resolution

We present a novel approach to solving definite descriptions in unrestricted text based on searching the web for a particular type of lexico-syntactic patterns. Using statistics on these patterns, we intend to recover the antecedents for a predefined subset of definite descriptions occurring in two types of anaphoric relations: identity anaphora and associative anaphora. Preliminary results obtained with this method are promising and compare well with other methods.
Developmental Normative Data for the Corsi Block-Tapping Task

The Corsi Block-Tapping task has been utilized as a measure of spatial memory in both clinical and research contexts for several decades. Despite its wide application, the task has been employed with extraordinary variability in administration and scoring and in the composition of stimulus item sets. We have generated a set of test items containing quasi-randomly derived block-tapping sequences. In another study, we investigated item difficulty as a function of path configuration and showed a decline in performance with increasing span capacity load. In the current cross-sectional study, we evaluated developmental differences in span capacity by measuring performances of school children from grade 1 (M age = 7 years) to grade 8 (M age = 14) and a young adult sample (M age = 21 years). Mean span capacity increased incrementally and linearly with age, and no gender difference was observed. The increase in performance with advancing age supports the notion that spatial immediate memory capacity increases with maturation throughout childhood. Comparisons indicated that the span capacity of eighth graders (M = 6.9) was not statistically different from that of the young adults (M = 7.1), suggesting an upper developmental plateau for spatial span in early adolescence. This study provides a normative database for this widely utilized measure of spatial memory. Some of the data contained in this paper were presented at the meeting of the International Neuropsychological Society, Honolulu, February 2003.
Comparison of Two Methods of RNA Extraction from Formalin-Fixed Paraffin-Embedded Tissue Specimens

The present study aimed to compare two different methods of extracting RNA from formalin-fixed paraffin-embedded (FFPE) specimens of diffuse large B-cell lymphoma (DLBCL). We further aimed to identify possible influences of variables—such as tissue size, duration of paraffin block storage, fixative type, primers used for cDNA synthesis, and endogenous genes tested—on the success of amplification from the samples. Both tested protocols used the same commercial kit for RNA extraction (the RecoverAll Total Nucleic Acid Isolation Optimized for FFPE Samples from Ambion). However, the second protocol included an additional step of washing with saline buffer just after sample rehydration. Following each protocol, we compared the RNA amount and purity and the amplification success as evaluated by standard PCR and real-time PCR. The results revealed that the extra washing step added to the RNA extraction process resulted in significantly improved RNA quantity and quality and improved success of amplification from paraffin-embedded specimens.
Maximizing the channel capacity of multicarrier transmission by suitable adaptation of the time-domain equalizer

An adaptation algorithm for determining the time-domain equalizer coefficients is described that maximizes the total channel capacity for all carriers of a multitone (discrete multitone) transmission. It takes into account the crosstalk noise environment and the interblock interference as a common disturbance. Furthermore, the leakage effect of the discrete Fourier transform (fast Fourier transform) is considered, too. Including this into the algorithm for the equalizer coefficients leads to a notable improvement in the signal-to-noise ratio, especially at lower frequencies for a typical asymmetrical digital subscriber line application.
Traffic Management using Multilevel Explicit Congestion Notification

Congestion remains the main obstacle to the Quality of Service on the Internet. We believe that a good solution to Internet congestion should optimally combine congestion signaling from network and source reaction, having as main goals: minimum losses and delays, maximum network utilization, fairness among flows and last but not least scalability of the solution. In this paper we present a new traffic management scheme based on an enhanced Explicit Congestion Notification (ECN) mechanism. In particular we used multilevel ECN, which conveys more accurate feedback information about the network congestion status than the current two levels ECN. We have designed a TCP source reaction that takes advantage of the extra information about congestion and tunes better its response to the congestion than the current schemes. Our analysis and simulations results shows that our scheme performed better than the current ones, having less losses, better network utilization, better fairness, and the solution is scalable.
The long-term psychological effects of child sexual abuse

Work on the long-term mental health sequels of child sexual abuse in Britain and Canada, in relation to family context, is reviewed. It is argued that the Canadian data show that sexual abuse in childhood is quite prevalent for both males and females, and is particularly prevalent in dysfunctional families. Such abuse often has a negative impact on self-esteem, and increases depression, suicidal feelings and behavior, and poor mental health. Further cross-cultural work in this field is proposed.
Personality in Work Organizations

Introduction to the Series Preface 1. The Role of Personality in Organizations John's Description of His Supervisor The View of John's Coworkers Use of Personality and Social Cognition to Explain Individual Differences in Framing General Comment: Personality in Organizations Organization of This Book 2. Fundamental Concepts of Personality Traits: The Behavioral Indicators of Personality Causes of Traits: Needs (Motives) The Mediating Role of Social Cognition in Need-Trait Relationships Concluding Comments 3. Personality Variables Prominent Traits in Contemporary Personality Broad Categories of the Social Cognitions That Are Used to Justify Characteristic Behavioral Adjustments Implicit Biases: Wanted or Unwanted 4. The Measurement of Personality in Organizational Settings Criteria for Evaluating Measurement Procedures Exemplars of Measurement Techniques for Personality An Efficient, Indirect System for Measuring Implicit Reasoning Biases Model for Empirical Validation Analyses Psychometric Evaluation of the Conditional Reasoning Test for Aggression Concluding Comments 5. Three Fertile Domains for Future Personality Research in Organizations Integrative Models of Personality Assessment Coherence Differential Framing Closing Comments References Index About the Authors
LT World: Ontology and Reference Information Portal

LT World (www.lt-world.org) is an ontology-driven web portal aimed at serving the global language technology community. Ontology-driven means, that the system is driven by an ontological schema to manage the research information and knowledge life-cycles: identify relevant concepts of information, structure and formalize them, assign relationships, functions and views, add states and rules, modify them. For modelling such a complex structure, we employ (i) concepts from the research domain, such as person, organisation, project, tool, data, patent, news, event (ii) concepts from the LT domain, such as technology and resource (iii) concepts from closely related domains, such as language, linguistics, and mathematics. Whereas the research entities represent the general context, that is, a research environment as such, the LT entities define the information and knowledge space of the field, enhanced by entities from closely related areas. By managing information holistically ― that is, within a research context ― its inherent semantics becomes much more transparent. This paper introduces LT World as a reference information portal through ontological eyes: its content, its system, its method for maintaining knowledge-rich items, its ontology as an asset.
A Chinese text paraphrase detection method based on dependency tree

Paraphrase detection is regarded as an important subtask in lots of natural language processing tasks. For example, in question answering, finding similar relations between questions needs paraphrase detection, also it is widely used in information retrieval, machine translation, document clustering, etc. Traditional solutions are mainly divided to two types. One is based on bag of words, which only considers the words in the sentences and similarity degrees between words. The other type is based on word embedding and deep neural networks, which learns word vectors to sentence vectors in deep models, in these models, deep layers may represent deep information in a sentence like phrase information and syntactic information, but these models may also lose some sentence information. We proposed a new method that considers word similarity and also directly uses dependency relations in sentences. We train our model in a Chinese text corpus. By working out dependency relation similarities and word similarities, we decide whether a sentence is a paraphrase of another one.
Proper English: Readings in Language, History and Cultural Identity

The texts in this book have been selected to illustrate the process by which particular forms of English usage are erected and validated as correct and standard. At the same time, the texts demonstrate how a certain group of people, and certain sets of cultural practices are privileged as correct, standard and central. Covering a period of 300 years, these writers, who include Locke, Swift, Webster, James, Newbolt and Marenbon, consider the questions of language change and decay, correct and incorrect usage and what to prescribe and proscribe. Reread in the light of recent debates about cultural identity - how is it constructed and maintained? what are its effects? - these texts attempt to demonstrate the formative roles of race, class and gender in the construction of "proper Englishness". This book should be of interest to students and teachers of English studies and language and linguistics including discourse theory and the history of language.
Glutathione Propagates Oxidative Stress Triggered by Myeloperoxidase in HL-60 Cells

Glutathione acts as a universal scavenger of free radicals at the expense of the formation of the glutathionyl radicals (GS·). Here we demonstrated that GS· radicals specifically interact with a reporter molecule, paramagnetic and non-fluorescent 4-((9-acridinecarbonyl)-amino)-2,2,6,6-tetramethylpiperidine-1-oxyl (Ac-Tempo), and convert it into a non-paramagnetic fluorescent product, identified as 4-((9-acridinecarbonyl)amino)-2,2,6,6-tetramethylpiperidine (Ac-piperidine). Horseradish peroxidase-, myeloperoxidase-, and cyclooxygenasecatalyzed oxidation of phenol in the presence of H2O2 and GSH caused the generation of phenoxyl radicals and GS· radicals, of which only the latter reacted with Ac-Tempo. Oxidation of several other phenolic compounds (e.g. etoposide and tyrosine) was accompanied by the formation of GS· radicals along with a characteristic fluorescence response from Ac-Tempo. In myeloperoxidase-rich HL-60 cells treated with H2O2 and phenol, fluorescence microscopic imaging of Ac-Tempo revealed the production of GS· radicals. A thiol-blocking reagent, N-ethylmaleimide, as well as myeloperoxidase inhibitors (succinyl acetone and azide), blocked formation of fluorescent acridine-piperidine. H2O2/phenolinduced peroxidation of major classes of phospholipids in HL-60 cells was completely inhibited by Ac-Tempo, indicating that GS· radicals were responsible for phospholipid peroxidation. Thus, GSH, commonly viewed as a universal free radical scavenger and major intracellular antioxidant, acts as a pro-oxidant during myeloperoxidase-catalyzed metabolism of phenol in HL-60 cells.
Poisson-Kingman partitions

This paper presents some general formulas for random partitions of a finite set derived by Kingman's model of random sampling from an interval partition generated by subintervals whose lengths are the points of a Poisson point process. These lengths can be also interpreted as the jumps of a subordinator, that is an increasing process with stationary independent increments. Examples include the two-parameter family of Poisson-Dirichlet models derived from the Poisson process of jumps of a stable subordinator. Applications are made to the random partition generated by the lengths of excursions of a Brownian motion or Brownian bridge conditioned on its local time at zero.
6K2-induced vesicles can move cell to cell during turnip mosaic virus infection

To successfully infect plants, viruses replicate in an initially infected cell and then move to neighboring cells through plasmodesmata (PDs). However, the nature of the viral entity that crosses over the cell barrier into non-infected ones is not clear. The membrane-associated 6K2 protein of turnip mosaic virus (TuMV) induces the formation of vesicles involved in the replication and intracellular movement of viral RNA. This study shows that 6K2-induced vesicles trafficked toward the plasma membrane and were associated with plasmodesmata (PD). We demonstrated also that 6K2 moved cell-to-cell into adjoining cells when plants were infected with TuMV. 6K2 was then fused to photo-activable GFP (6K2:PAGFP) to visualize how 6K2 moved intercellularly during TuMV infection. After activation, 6K2:PAGFP-tagged vesicles moved to the cell periphery and across the cell wall into adjacent cells. These vesicles were shown to contain the viral RNA-dependent RNA polymerase and viral RNA. Symplasmic movement of TuMV may thus be achieved in the form of a membrane-associated viral RNA complex induced by 6K2.