Miracle-dz/UniFAR-FTUs huggingface dataset:
A systematic nomenclature for new translation initiation factor genes from S. pombe and other fungi

Eukaryotic translation initiation factors and their corresponding genes have been characterized using biochemical and genetic methods from a variety of different organisms. The designations of the factors relate to their apparent roles in the biochemical process. Many gene names indicate genetic interactions with other genes or the functional attributes used to identify them. On the other hand, progress in systematic sequencing of the genomes of organisms like Saccharomyces cerevisiae and Schizosaccharomyces pombe has revealed many genes homologous to known translation initiation factor genes. The genes defined by the systematic sequencing approach are assigned numerical designations completely unrelated to their biological function. So far there have been publications on only three genes encoding translation initiation factors from Schizosaccharomyces pombe. We therefore see this an an ideal opportunity to propose a systematic and logical nomenclature for genes encoding translation initiation factor genes that can be applied to all further genes of this type that are characterized in this fission yeast. Copyright © 1999 John Wiley & Sons, Ltd.
Ring polymers as model bacterial chromosomes: confinement, chain topology, single chain statistics, and how they interact

Chromosomes in living cells are strongly confined but show a high level of spatial organization. Similarly, confined polymers display intriguing organizational and segregational properties. Here, we discuss how ring topology influences self-avoiding polymers confined in a cylindrical space, i.e. individual polymers as well as the way they interact. Our molecular dynamics simulations suggest that a ring polymer can be viewed as a “parallel connection” of two linear subchains, each trapped in a narrower imaginary tube. As a consequence, ring topology “stiffens” individual chains about fivefold and enhances their segregation appreciably, as if it induces extra linear ordering. Using a “renormalized” Flory approach, we show how ring topology influences individual chains in the long chain limit. Our polymer model quantitatively explains the long-standing observations of chromosome organization and segregation in E. coli.
Early submucous resection of nasal septal cartilage. A pilot study in canine pups.

An experimental design was executed to determine the effects on snout and midfacial growth of performing submucous resections of large pieces of septal cartilage on 6-week-old canine pups. Some pieces of intact fresh cartilage were autografted. Gross findings failed to show any perceptible growth disturbances, and the autografts continued to grow more or less proportionately to the rest of the septum.
Pathophysiology, Prevention and Management of Chronic Kidney Disease in the Hypertensive Patient With Diabetes Mellitus

The authors concisely review the main clinical issues arising in the management of the hypertensive patient with type 2 diabetes, in whom chronic kidney disease is prevalent and heralds increased cardiovascular morbidity and mortality. Special attention is paid to the clinical meaning, relevance and limits of albumin excretion and glomerular filtration rate, the two widely used markers of reduced kidney function during the course of chronic diseases like diabetes and hypertension. The main therapeutic strategies involving blood pressure and glycemic control, treatment of dyslipidemia and improvement of lifestyle are discussed from the viewpoint of a general practitioner dealing with the clinical complexity of these patients. J Clin Hypertens (Greenwich). 2011;13:252–257. © 2011 Wiley Periodicals, Inc.
Transmission Between Retail And Producer Prices For Main Vegetable Crops In Tunisia

Recently in Tunisia, vegetables prices increased rapidly, especially green pepper, tomato and potato. The sharp rise in prices led to the deterioration of consumer’s purchasing power and the depletion of their food basket. Since price is the mechanism linking the different stages of the production chain, information on price transmission and causality can provide guidance on the actions to be taken by the actors. The results of the price transmission show a long-term relationship between retail prices and producer prices. The important role played by intermediaries influences the symmetric transmission mode. In the case of tomatoes, the transmission is asymmetric and the causality has gone from retail to producer prices, whereas for potatoes the transmission is symmetrical and the causality of production prices towards the retail price. For green pepper the transmission is also symmetrical and the causality is from retail price to the production price. The transmission depends on the causality but it also depends on the supply of the market and if the product is storable or not. Actions to be undertaken by the actors must concentrate on the control and transparency of commercial transactions along the food chain. Prices regulation must be placed on the wholesale level and not on the level of the producers in order to clear the margin of intermediaries and avoid the shortage of certain products in markets.
Millimeter and submillimeter planar measurement setup

A three-axes planar measurement setup for antenna characterization and inverse scattering applications is described. The need for a new measurement facility capable of working at millimeter and sub millimeter frequency bands is the main motivation of this work. The system can be divided into two main blocks devoted to mechanical and radiofrequency control respectively. Frequency band is extended up to 330 GHz by means of mixing heads, and a working surface of 1450×1500×1100 mm, with 0.01 mm positioning accuracy is achieved. Measurement setup is provided with an easy-to-use graphical user interface allowing configuration of mechanical and radiofrequency devices, as well as graphical representation of the results and post processing tasks.
Does Your Care Plan Tell My Story? Documenting Aspects of Personhood in Long-Term Care

Learning about aspects of one's personhood allows the nurse to know the individual as a person and to individualize the care provided. A pilot project was conducted on a supportive residential care unit to explore why health records in long-term care rarely reveal who the person is. Five nurse participants generated a list of features of an individual's personhood that they felt should be known by members of the team. They subsequently gathered that information from a variety of sources, with documentation in a designated location provided on the plan of care. They were thus able to overcome some of the previously encountered barriers to collecting and documenting the personhood data reflecting their knowledge of the individual as a person. Although nurses were successful in learning who the persons were, changes in approach to care as a result of the new knowledge have not been measured.
An empirical table based HBT large signal model

An Empirical Table Based HBT Large Signal Model is proposed and experimentally evaluated. The important features of the model are that the model is a combination between an Empirical HBT model and a Table Based Model. The main model parameters are determined directly from measurements. The model was evaluated by DC, S-parameters, Power Spectrum and LSNA measurements. Good correspondence was obtained between measurements and simulations.
Induction of Antifertility with Lupeol Acetate in Male Albino Rats

The present study was undertaken to evaluate the antifertility activity of the active principle, i.e. lupeol acetate, isolated from benzene extract of Alstonia scholaris in male albino rats. The treatment with lupeol acetateat the dose level of 10 mg/rat/day did not cause any significant change in the body weights, but significant reduction in the weight of reproductive organs, i.e. testes, epididymides, seminal vesicle and ventral prostate, was observed. Testicular sperm count, epididymal sperm count and motility were found significantly declined when compared with controls, which resulted in reduction of male fertility by 100%. Arrest of spermatogenesis was noted at various stages with production of primary spermatocytes (preleptotene and pachytene), secondary spermatocytes and step-19 spermatids were decreased by 52.36, 54.91, 55.67 and 69.65%, respectively. The seminiferous tubules appeared reduced in size by 24.62%. Cross-sectional surface area of Sertoli cells as well as their counts were found to be significantly depleted. Leydig cell nuclear area and number of mature Leydig cells were decreased by 27.65 and 35.47%. Biochemical parameters of tissues i.e. protein, sialic acid, glycogen and cholesterol content of testes and seminal vesicular fructose also showed significant reduction.
Membrane potential and conductance during transport of sodium, potassium and rubidium in frog muscle

1. Muscles with high intracellular sodium concentrations can extrude sodium into solutions which contain 10 m‐equiv/l. of either potassium or rubidium. Potassium or rubidium replaces the extruded intracellular sodium. These cation movements take place equally well when the external anion is chloride or sulphate, though muscles deteriorate if left for long periods in sulphate solutions.
Exploring High-Dimensional Topologies for NoC Design Through an Integrated Analysis and Synthesis Framework

Networks-on-chip (NoCs) address the challenge to provide scalable communication bandwidth to tiled architectures in a power-efficient fashion. The 2-D mesh is currently the most popular regular topology used for on-chip networks in tile-based architectures, because it perfectly matches the 2-D silicon surface and is easy to implement. However, a number of limitations have been proved in the open literature, especially for long distance traffic. Two relevant variants of 2-D meshes are explored in this paper: high-dimensional and concentrated topologies. The novelty of our exploration framework includes the use of fast and accurate transaction level simulation to provide constraints to the physical synthesis flow, which is integrated with standard industrial toolchains for accurate physical implementation. Interestingly, this work illustrates how effectively the compared topologies can handle synchronization-intensive traffic patterns and accounts for chip I/O interfaces.
Computerized tomography-guided kryorhizotomy in 76 patients with lumbar facet joint syndrome.

OBJECT The authors prospectively evaluated the therapeutic effect of computerized tomography (CT)-guided kryorhizotomy in the treatment of patients with lumbar facet joint syndrome (LFJS) and assessed prognostic factors that predict this effect. METHODS Between February 2001 and March 2004, CT-guided kryorhizotomy of facet joints was performed in 76 patients with LFJS. A diagnosis was established after three positive CT-guided medial nerve branch blocks. Outcome was determined by evaluating the results of a standardized questionnaire, including visual analog scale (VAS) score, use of medication, ability to work, and physical conditions. Measurement was performed before treatment and repeated postoperatively at 3 days, 3 months, and every 6 months thereafter. On September 2004 all patients underwent clinical reevaluation. The median follow-up period was 22.5 months (range 6-43 months); the median interval to pain reduction was 6 months (range 0.1-31 months) after the first kryorhizotomy. The mean VAS pain score was 6.7 preoperatively and 2.9, 3.2, and 3.4 at 3 days, 3 months, and 6 months postoperatively, respectively. In 40% of patients pain was reduced for 12 months or longer. In patients in whom there was no prior surgical treatment of the relevant spinal segment, the duration of pain relief was significantly longer than in patients who had previously undergone surgery (p < 0.03). Eighteen patients underwent a second, seven a third, and one a fourth kryorhizotomy. No patient reported any side effect. The use of CT guidance guarantees an exact needle-tip position control and documentation for repeated procedures. CONCLUSIONS Computerized tomography-guided kryorhizotomy is a minimally invasive and repeatable treatment that yields good long-term results in patients with LFJS.
‘Smart’ Visitor Mobility Management in the Tourist-Historic City

The multi-disciplinary study tries to establish interrelations between online mobile technology used for heritage interpretation and visitor mobility behaviour, exploring the implications that the changed behaviour patterns have for applied visitor management in UNESCO World Heritage listed historic city centres. Ubiquitous online mobile technology disperses delimitations between activities, time and space which affects and fundamentally changes everyday life including touristic utilized spaces and activities. In this ‘liquid modernity’, tourism is perceived as an essential form of mobility, increasingly changing under the influence of online mobile technologies. With this changing landscape of both, tourism and online mobile technology, interpretation of space, communication of information and the ensuing movement within a destination have to be amended accordingly. Tourism is often considered as one of the few options for economic vitality in historic cities. However, there is a fine line between tourism being an added value and support to conservation, and tourism becoming the reason for conservation. This study scrutinizes prevailing visitor mobility management strategies in historic cities in the context of changing visitor movement triggered by the increasing influence of online mobile media. For this purpose the technology awareness and acceptance of destination management organisations and the utilization of interpretive online mobile media is explored by conducting an online survey in 127 UNESCO World Heritage historic city centres, followed by an in-depth analysis in selected study areas of the compatibility of currently applied visitor mobility management strategies with prevailing behaviour of ‘connected’ visitors using sentiment analysis on data generated from social media mining.
Targets of B‐cell antigen receptor signaling: the phosphatidylinositol 3‐kinase/Akt/glycogen synthase kinase‐3 signaling pathway and the Rap1 GTPase

In this review, we discuss the role of phosphatidylinositol 3-kinase (PI3K) and Rap 1 in B-cell receptor (BCR) signaling. PI3K produces lipids that recruit pleckstrin homology domain-containing proteins to the plasma membrane. Akt is a kinase that the BCR activates in this manner. Akt phosphorylates several transcription factors as well as proteins that regulate apoptosis and protein synthesis. Akt also regulates glycogen synthase kinase-3, a kinase whose substrates include the nuclear factor of activated T cells (NF-AT)cl and beta-catenin transcriptional activators. In addition to Akt, PI3K-derived lipids also regulate the activity and localization of other targets of BCR signaling. Thus, a key event in BCR signaling is the recruitment of PI3K to the plasma membrane where its substrates are located. This is mediated by binding of the Src homology (SH) 2 domains in PI3K to phosphotyrosine-containing sequences on membrane-associated docking proteins. The docking proteins that the BCR uses to recruit PI3K include CD19, Cbl, Gab1, and perhaps Gab2. We have shown that Gab1 colocalizes PI3K with SH2 domain-containing inositol phosphatase (SHIP) and SHP2, two enzymes that regulate PI3K-dependent signaling. In contrast to PI3K, little is known about the Rap1 GTPase. We showed that the BCR activates Rap1 via phospholipase C-dependent production of diacylglycerol. Since Rap1 is thought to regulate cell adhesion and cell polarity, it may be involved in B-cell migration.
A relational view of self-protection amongst China’s food safety crises

ABSTRACT This article adopts a relational view to unpack farmers’ self-protection mechanisms and alternative safe food access when food safety crises escalate in China. It integrates literature from psychological and agricultural economy studies to investigate the obligational and emotional relationships between farmers and outside parties. Building on inductive analysis based on 60 farmers in Shouguang County at Shandong Province, China, we identified four types of interpersonal relationships developed by farmers. We further developed an emotion-obligation matrix to examine the relational boundary between “insiders” and “outsiders”. We noted that when balancing relational versus economic interests, farmers tend to provide insiders with “family food” and outsiders with “stranger food”.
Refinement of Ischemic Stroke Risk in Patients with Atrial Fibrillation and CHA2DS2‐VASc Score of 1

Patients with atrial fibrillation (AF) with CHA2DS2‐VASc score of 1 (where CHA2DS2‐VASc is CHA2DS2‐Vascular disease, Age 65–74 years, Sex category) are recommended to receive antithrombotic therapy. Nonetheless, it remains unclear whether individual components that constitute CHA2DS2‐VASc score contribute equally to the ischemic stroke risk, particularly in patients with CHA2DS2‐VASc score of 1. The objective was to describe and compare the risk of ischemic stroke of the six individual components constituting CHA2DS2‐VASc among AF patients with CHA2DS2‐VASc score of 1.
Reliable fuzzy output feedback control of nonlinear parabolic distributed parameter systems with sensor faults

This paper studies the problem of output feedback control for a class of nonlinear spatially distributed systems described by parabolic partial differential equations (PDEs) with Markovian jumping sensor faults. The nonlinear parabolic distributed parameter systems (DPSs) are firstly expressed by T-S fuzzy models with parameter uncertainties and the aim is to design a reliable distributed fuzzy static output feedback (SOF) Proportional-spatial Derivative (P-sD) controller guaranteeing the robust stochastic exponential stability of the resulting closed-loop system. Based on a Markovian Lyapunov functional, a descriptor system approach is developed for reliable fuzzy SOF P-sD controller synthesis for the underlying nonlinear parabolic DPSs. It is shown that the controller gains can be obtained by solving a set of finite linear matrix inequalities. Finally, an example is given to illustrate the effectiveness of the proposed method.
Indicators of Financial Stability of the Ukrainian Banking System

The object of this paper is to identify macroeconomic indicators that are most suitable for detection of instabilities in the Ukrainian banking system and for justification of the methods of evaluation of the financial stability of the Ukrainian banking system based on an integral index. It analyzes the dynamics of macroeconomic indicators of Ukraine's economy and proposes to use the ratio of the growth rate of loans to non-financial corporations to total GDP as the key macroeconomic indicator of financial stability, with GDP dynamics and dynamics of loan/deposit portfolio ratio of Ukrainian banks being supplementary indicators. It analyzes existing methods of formation of the integral index of the financial stability of the banking system and reveals their limitations. It refines the methods of the banking system financial stability evaluation by adding calculation of taxonomic indicators for the groups of capital adequacy, liquidity, business activity, performance and finding the overall financial stability index as a geometric mean of the taxonomic indicators. It was found that the dynamics of the proposed integral index is in agreement with the stages of development of the Ukrainian banking system; therefore it is practical to use it as a financial stability indicator.
Does stage tailoring matter in brief alcohol interventions for job-seekers? A randomized controlled trial.

AIMS To investigate whether or not a stage tailored intervention is more effective than a non-stage tailored intervention of the same intensity in reducing alcohol use among job-seekers with unhealthy alcohol use, and whether initial motivation to change is a moderator of efficacy. DESIGN A three-group randomized controlled trial with 3-, 6- and 15-month follow-ups. SETTING Three job agencies in Germany. PARTICIPANTS A total of 1243 job-seekers with unhealthy alcohol use were randomized to (i) stage tailored intervention based on the transtheoretical model of change (ST), (ii) non-stage tailored intervention based on the theory of planned behaviour (NST) and (iii) assessment only (controls). Participants received feedback letters and manuals at baseline and 3 months later. MEASUREMENTS Piecewise latent growth models were calculated measuring change in 'alcohol use' from baseline to month 3 (active intervention phase) and from months 3 to 15 (post-intervention phase, primary outcome). Motivation to change was included as a 4-point continuous measure. FINDINGS All groups reduced alcohol use from months 0 to 3 (controls: mean = -0.866, NST: mean = -0.883, ST: mean = -0.718, Ps ≤ 0.001). Post-intervention (months 3-15), low-motivated individuals in the ST group showed a greater reduction than those in the control group (β = 0.135, P = 0.039, Cohen's d = 0.42) and in the NST group (β = 0.180, P = 0.009, Cohen's d = 0.55). In contrast, compared to the ST group (β = 0.030, P = 0.361), alcohol use decreased more strongly with higher initial motivation in the NST group (β = -0.118, P = 0.010). CONCLUSIONS Among job-seekers with high levels of alcohol consumption, an intervention tailored to motivational 'stage of change' was more effective than a non-stage tailored intervention for reducing alcohol use 15 months after baseline assessment in participants with low initial motivation to change.
Does Corporate Philanthropy Contribute to Product Market Competition? - The Complementary Role of Advertising Investment

Despite the relationship between CSR initiatives and firm performance has been a subject of extensive investigation, existing research rarely focuses on the complementary role of advertising investment in exploring the boundary mechanism for the financial implications of corporate social responsibility. This study investigates a theoretical framework that hypothesizes (1) the impact of corporate philanthropy on product market competition and (2) the role of advertising investment in explaining the variability of this impact among different firms. Empirical analysis of secondary information for Chinese firms listed on stock exchanges from 2010−2016 shows that corporate philanthropy can indeed promote product market competition, and the results also indicate that advertising investment plays a complementary role in the corporate philanthropy-product market competition relationship. Keywords—Corporate philanthropy; Product Market Competition; Advertising Investment