Miracle-dz/UniFAR-FTUs huggingface dataset:
ADAM9 Expression Is Associate with Glioma Tumor Grade and Histological Type, and Acts as a Prognostic Factor in Lower-Grade Gliomas

The A disintegrin and metalloproteinase 9 (ADAM9) protein has been suggested to promote carcinoma invasion and appears to be overexpressed in various human cancers. However, its role has rarely been investigated in gliomas and, thus, in the current study we have evaluated ADAM9 expression in gliomas and examined the relevance of its expression in the prognosis of glioma patients. Clinical characteristics, RNA sequence data, and the case follow-ups were reviewed for 303 patients who had histological, confirmed gliomas. The ADAM9 expression between lower-grade glioma (LGG) and glioblastoma (GBM) patients was compared and its association with progression-free survival (PFS) and overall survival (OS) was assessed to evaluate its prognostic value. Our data suggested that GBM patients had significantly higher expression of ADAM9 in comparison to LGG patients (p < 0.001, t-test). In addition, among the LGG patients, aggressive astrocytic tumors displayed significantly higher ADAM9 expression than oligodendroglial tumors (p < 0.001, t-test). Moreover, high ADAM9 expression also correlated with poor clinical outcome (p < 0.001 and p < 0.001, log-rank test, for PFS and OS, respectively) in LGG patients. Further, multivariate analysis suggested ADAM9 expression to be an independent marker of poor survival (p = 0.002 and p = 0.003, for PFS and OS, respectively). These results suggest that ADAM9 mRNA expression is associated with tumor grade and histological type in gliomas and can serve as an independent prognostic factor, specifically in LGG patients.
Why do some UK SMEs still find the implementation of a new product development process problematical

Purpose – The long‐term survival of a business often hinges on its ability to successfully introduce new products into the marketplace. These new products and their successful development can be the lifeblood of a company. This paper aims to examine why product development delays occur in SMEs, the nature of these delays, and what can be done in order to avoid them.Design/methodology/approach – This research is exploratory in nature and provides empirical support to several propositions found in the innovation management literature on the development of new products.Findings – Various reasons for delays in new product development are found, including poor definition of product requirements, technological uncertainties, senior management support, lack of resources, and poor project management. Major concerns raised included management and organisational style, lack of attention to detail, limited support for innovation, lack of strategic thinking, and poor manufacturing capabilities.Originality/value – The.
Temporal Identification of Latent Communities on Twitter

User communities in social networks are usually identified by considering explicit structural social connections between users. While such communities can reveal important information about their members such as family or friendship ties and geographical proximity, they do not necessarily succeed at pulling like-minded users that share the same interests together. In this paper, we are interested in identifying communities of users that share similar topical interests over time, regardless of whether they are explicitly connected to each other on the social network. More specifically, we tackle the problem of identifying temporal topic-based communities from Twitter, i.e., communities of users who have similar temporal inclination towards the current emerging topics on Twitter. We model each topic as a collection of highly correlated semantic concepts observed in tweets and identify them by clustering the time-series based representation of each concept built based on each concept's observation frequency over time. Based on the identified emerging topics in a given time period, we utilize multivariate time series analysis to model the contributions of each user towards the identified topics, which allows us to detect latent user communities. Through our experiments on Twitter data, we demonstrate i) the effectiveness of our topic detection method to detect real world topics and ii) the effectiveness of our approach compared to well-established approaches for community detection.
The Removal of Rubber Particles from Skim Rubber Latex by Batch Adsorption Technique Using Organoclay

Clay modified with organic surfactant, DDA-MMT, Closite 15A, 20A, and 25A, act as effective adsorbent in organic wastewater applications. Due to the inorganic character of MMT, the organic adsorption ability of MMT was improved by replacing the exchangeable cation. The experiment was tested using wastewaters from removal of skim NR from concentrated NR industry. The ability to remove organic contaminants from aqueous solution, based on different molecular structures of organically modified clays, was evaluated using UV/VIS spectroscopy, chemical oxygen demand (COD), and biological oxygen demand (BOD). In addition, other quality indicators of wastewater and product were measured before and after the treatment with coagulating method.
Perturbations From Ducts on the Modes of Acoustic Thermometers

We examine the perturbations of the modes of an acoustic thermometer caused by circular ducts used either for gas flow or as acoustic waveguides coupled to remote transducers. We calculate the acoustic admittance of circular ducts using a model based on transmission line theory. The admittance is used to calculate the perturbations to the resonance frequencies and half-widths of the modes of spherical and cylindrical acoustic resonators as functions of the duct’s radius, length, and the locations of the transducers along the duct's length. To verify the model, we measured the complex acoustic admittances of a series of circular tubes as a function of length between 200 Hz and 10 kHz using a three-port acoustic coupler. The absolute magnitude of the specific acoustic admittance is approximately one. For a 1.4 mm inside-diameter, 1.4 m long tube, the root mean square difference between the measured and modeled specific admittances (both real and imaginary parts) over this frequency range was 0.018. We conclude by presenting design considerations for ducts connected to acoustic thermometers.
Port Decoupling for Small Arrays by Means of an Eigenmode Feed Network

An alternative approach to port decoupling and matching of arrays with tightly coupled elements is proposed. The method is based on the inherent decoupling effect obtained by feeding the orthogonal eigenmodes of the array. For this purpose, a modal feed network is connected to the array. The decoupled external ports of the feed network may then be matched independently by using conventional matching circuits. Such a system may be used in digital beam forming applications with good signal-to-noise performance. The theory is applicable to arrays with an arbitrary number of elements, but implementation is only practical for smaller arrays. The principle is illustrated by means of two examples.
Minimal backups of cryptographic protocol runs

As cryptographic protocols execute they accumulate information such as values and keys, and evidence of properties about this information. As execution proceeds, new information becomes relevant while some old information ceases to be of use. Identifying what information is necessary at each point in a protocol run is valuable for both analysis and deployment. We formalize this necessary information as the minimal backup of a protocol. We present an analysis that determines the minimal backup at each point in a protocol run. We show that this minimal backup has many uses: it serves as a foundation for job-migration and other kinds of fault-tolerance, and also assists protocol designers understand the structure of protocols and identify potential flaws. In a cryptographic context it is dangerous to reason informally. We have therefore formalized and verified this work using the Coq proof assistant. Additionally, Coq provides a certified implementation of our analysis. Concretely, our analysis and its implementation consume protocols written in a variant of the Cryptographic Protocol Programming Language, CPPL.
Spinning process using robot technology

product. It is suitable for production of a wide variety of products in small quantities due to low cost forming dies. We have achieved fabrication of non-axisymmetric shapes by using robot technology, which was difficult to realize by conventional methods. A prototype of a practical spinning machine has been developed in collaboration with a spinning machinery manufacturer. In this research, we have basically set preference for commercial realization over academic contribution. This research was carried out in a bottom-up and trial-and-error manner, and the targets of this research were frequently modified depending on the situation. Bricolage, utilizing the combination of available and limited resources at hand, has played a key role in the research activity. Decision-making has reflected Three-actuality theory, which values actual field site, actual material, and actuality. We have added the increase of customer satisfaction to the criteria of value and have set the sales activities as a part of the research. キーワード： スピニング加工、ロボット、塑性加工、ボトムアップ、ブリコラージュ、三現主義
Through-Thickness Mechanical Characterization of Woven Fabric Composites

The objective of this study was to investigate the interlaminar orthrough-thickness deformation and failure of woven fabric composites subjected toquasi-static loading and develop testing methods and specimens that would provideboth elastic properties and strengths for moderately thick composites. This study wasperformed on a thick composite consisting of a satin weave carbon fabricimpregnated with an amine-cured epoxy resin. All through-thickness mechanicalproperties under compressive, tensile, and shear loading with their correspondingfailure mechanisms were determined. These properties were also correlated with thecorresponding ones for a unidirectional composite having the same fiber and matrix.
Out of Control!? How Loss of Self-Control Influences Prosocial Behavior: The Role of Power and Moral Values

Lack of self-control has been suggested to facilitate norm-transgressing behaviors because of the operation of automatic selfish impulses. Previous research, however, has shown that people having a high moral identity may not show such selfish impulses when their self-control resources are depleted. In the present research, we extended this effect to prosocial behavior. Moreover, we investigated the role of power in the interaction between moral identity and self-control depletion. More specifically, we expected that power facilitates the externalization of internal states, which implies that for people who feel powerful, rather than powerless, depletion decreases prosocial behavior especially for those low in moral identity. A laboratory experiment and a multisource field study supported our predictions. The present finding that the interaction between self-control depletion and moral identity is contingent upon people’s level of power suggests that power may enable people to refrain from helping behavior. Moreover, the findings suggest that if organizations want to improve prosocial behaviors, it may be effective to situationally induce moral values in their employees.
Frankenplace: Interactive Thematic Mapping for Ad Hoc Exploratory Search

Ad hoc keyword search engines built using modern information retrieval methods do a good job of handling fine-grained queries. However, they perform poorly at facilitating spatial and spatially-embedded thematic exploration of the results, despite the fact that many queries, e.g. "civil war," refer to different documents and topics in different places. This is not for lack of data: geographic information, such as place names, events, and coordinates are common in unstructured document collections on the web. The associations between geographic and thematic contents in these documents can provide a rich groundwork to organize information for exploratory research. In this paper we describe the architecture of an interactive thematic map search engine, Frankenplace, designed to facilitate document exploration at the intersection of theme and place. The map interface enables a user to zoom the geographic context of their query in and out, and quickly explore through thousands of search results in a meaningful way. And by combining topic models with geographically contextualized search results, users can discover related topics based on geographic context. Frankenplace utilizes a novel indexing method called geoboost for boosting terms associated with cells on a discrete global grid. The resulting index factors in the geographic scale of the place or feature mentioned in related text, the relative textual scope of the place reference, and the overall importance of the containing document in the document network. The system is currently indexed with over 5 million documents from the web, including the English Wikipedia and online travel blog entries. We demonstrate that Frankenplace can support four distinct types of exploratory search tasks while being adaptive to scale and location of interest.
Shape Complexity from Image Similarity

We present an approach to automatically compute the complexity of a given 3D shape. Previous approaches have made use of geometric and/or topological properties of the 3D shape to compute complexity. Our approach is based on shape appearance and estimates the complexity of a given 3D shape according to how 2D views of the shape diverge from each other. We use similarity among views of the 3D shape as the basis for our complexity computation. Hence our approach uses claims from psychology that humans mentally represent 3D shapes as organizations of 2D views and, therefore, mimics how humans gauge shape complexity. Experimental results show that our approach produces results that are more in agreement with the human notion of shape complexity than those obtained using previous approaches.
The role of medial prefrontal cortex in early social cognition

One major function of our brain is to enable us to behave with respect to socially relevant information. Much research on how the adult human brain processes the social world has shown that there is a network of specific brain areas, also called the social brain, preferentially involved during social cognition. Among the specific brain areas involved in the adult social brain, functional activity in prefrontal cortex (PFC), particularly the medial prefrontal cortex (mPFC), is of special importance for human social cognition and behavior. However, from a developmental perspective, it has long been thought that PFC is functionally silent during infancy (first year of life), and until recently, little was known about the role of PFC in the early development of social cognition. I shall present an emerging body of recent neuroimaging studies with infants that provide evidence that mPFC exhibits functional activation much earlier than previously thought, suggesting that the mPFC is involved in social information processing from early in life. This review will highlight work examining infant mPFC function across a range of social contexts. The reviewed findings will illustrate that the human brain is fundamentally adapted to develop within a social context.
Influence of compression and network impairments on the picture quality of video transmissions in tele-medicine

With the continuous increase in network capacities, video transmissions in medicine are becoming an effective tool for second-opinion diagnosis, archiving and teaching environments. This study investigates video compression delay times and transmission impairments for different compression formats and describes the resulting picture qualities. For the evaluation, endoscopic video sequences were produced with different compression formats and bandwidth requirements. In a second step, an impairment tool was used to introduce error rates to the video material to simulate network behavior. A group of medical experts evaluated the video sequences, rating the visibility of errors, artifacts, sharpness, overall picture quality and suitability for medical diagnosis. The results clearly establish lower bounds for picture quality deteriorated by compression and network impairments, and introduce limits for medical assessments.
Morphological evidence of the shedding of chondrocytes from the articular surface in neonatal rats: Relationship to the interlacunar network

The superficial zone of the femoral head articular cartilage of 5‐ to 15‐day old rats was examined by light and electron microscopy for evidence of shedding into the joint space. Chondrocytes deepest in the superficial zone were round, surrounded by a capsule, and connected to adjacent chondrocytes by the interlacunar network, whereas cells in the middle ofthe zone appeared similar but with less cytoplasm. At the articular surface, chondrocytes were small, with pyknotic nuclei and poorly defined organelles. These cells occasionally protruded from the articular surface but maintained at least partial connection with the network and their capsule. Depressions in the articular surface were lined with material similar to that of the network and were the only locations found where the network did not terminate at a cell surface. This static evidence suggested at least two hypotheses: (1) Degenerating chondrocytes moved up through the superficial zone tothe articular surface and were shed into the joint space. This movement maybe facilitated by the network as part of neonatal cartilage development. (2) During joint formation, the surface of the articular cartilage was eroded down tothe chondrocytes, which were exposed to the joint fluid, causing cell degeneration, death, and shedding. Evidence of cell shedding was rarely seen after 2 weeks of age. Likewise, the interlacunar network disappeared from the superficial zone during this period. A physiological as well as structural relationship may exist between the chondrocytes and interlacunar network.
Thermo-mechanical analysis of a W-Ta-ODS divertor transition joint

Development of a robust transition joint between refractory-based PFC components and external cooling piping system is critical for the successful operation of future fusion power reactors. A helium cooled tungsten-based divertor and a steel-based cooling system joint is particularly challenging, due in part to the large mismatch of thermo-physical properties between the materials and because of the high operating temperatures. A strong metallurgical bond is required in such a duplex joint structure. Drawing on broad existing industrial experience, a joint was designed using Ta as a transition material between W and steel. Thermo-structural FEM analyses were performed to investigate the mechanical response of this joint during powerup, steady state, and shut down of divertor operation.
An efficient distributed privacy-preserving recommendation system

Implementing a recommendation system on the data of mobile social networks exploits knowledge about behavior and preferences of its users and hence raises serious privacy concerns. Leveraging the wealth of aggregated information in these services promises an immense benefit by allowing suggestions for presumably appreciated, yet previously unseen restaurants, sights, and further types of locations. Privacy preserving recommenders based on homomorphic encryption have been proposed, which have a systematic draw-back: while recommender systems often store their information as real values, all homomorphic encryption schemes used today process only data from other algebraic structures, e.g., the ring of integers modulo some integer n. Therefore, we present a novel distributed recommender and a homomorphic encryption scheme, which works directly on real numbers and which possesses some remarkable properties: it is conceptually simple, efficient, and provably secure.
GENERALIZED SIZE EFFECT EQUATION FOR QUASIBRITTLE MATERIALS

— Structures made of quasibrittle materials show a marked decrease in strength as their size increases; this is the well known size effect on strength. This contribution proposes a general formula to predict with great accuracy the size effect of pre-cracked specimens. Such a formula provides the basis to determine experimentally the fracture parameters of a cohesive crack model from the measurement of the peak load in specimens with an initial crack. The formula is applicable whenever the fracture of the material can be described by a cohesive crack model with initial linear softening, as is generally accepted for concrete. Experimental evidence is presented showing that the formula is reasonably accurate also for rock.
Dot Pattern Designing on Light Guide Plate of Backlight Module by the Method of Molecular Potential Energy

An approach for dot pattern designing on the light guide plate of backlight module is proposed in this paper. The proposed approach employs molecular potential energy model to generate random-dot patterns for light guide designed for backlight systems. The methods of developing dot patterns are various. We chose AutoCAD-VBA programme method for its visible interface. The algorithm can be divided into two steps: Firstly, an AutoCAD-VBA programme is compiled to generate random initial dot patterns, which contains 69 091 points. Secondly, a variable equilibrium distances system are found by the Mathematica software to fine tune distances among those points. At last, we have derived dot patterns which can satisfy the uniformity luminance requirement demanded by liquid-crystal displays, testing results show that the optical uniformity can reach 89.3%.
Etl2, a novel putative type-I cytokine receptor expressed during mouse embryogenesis at high levels in skin and cells with skeletogenic potential.

The regulatory effects of signaling proteins like hormones, growth factors, and cytokines are mediated by specific cell surface receptors which are grouped into distinct families on the basis of structural criteria. Here we report on the isolation and embryonic expression of a novel mouse gene, Etl2 (enhancer trap locus 2) which, based on its deduced amino acid sequence, constitutes a new member of the cytokine type-I receptor family. Among type-I receptors Etl2 is most similar to the alpha subunits of the human ciliary neurotrophic factor (CNTF) receptor and the mouse interleukin-6 (IL6) receptor with 32 and 30% identical amino acids, respectively. From Day 9 p.c. (postcoitum) onward low levels of Etl2 mRNA were detected in mesenchymal cells throughout the embryo and in parts of the nervous system, in particular in the ependymal linings of the spinal cord and the developing brain vesicles and in the neuronal layer of the retina. Highest levels of Etl2 expression were found on Day 12.5 p.c. in the craniofacial mesenchyme and during subsequent development in mesenchymal cells around all developing cartilages. At later stages, Etl2 transcripts were abundant in the dental papilla, the dermis, and hair follicles, as well as in the perichondrium and periost, i.e., in regions containing chondro and osteo progenitor cells. Etl2 mRNA was not detected, however, in mature odontoblasts, chondroblasts, osteoblasts, chondrocytes, and osteocytes. Our results suggest that Etl2 is a new orphan receptor belonging to the type-I cytokine receptor family and that Etl2 might have regulatory functions, particularly in the control of proliferation and/or differentiation of skeletogenic progenitor and other mesenchymal cells.