Miracle-dz/UniFAR-FTUs huggingface dataset:
Normal serum alkaline phosphatase isoenzymes examined by acrylamide and starch gel electrophoresis and by isoenzyme analysis using organ-specific inhibitors.

The serum alkaline phosphatase isoenzymes of 56 normal individuals have been studied from three points of view: the partition of intestinal type alkaline phosphatase from nonintestinal by L-phenylalanine inhibition and their respective heat sensitivities; the performance of starch gel electrophoresis; and acrylamide gel electrophoresis of all sera. The improved acrylamide gel electrophoresis technic did separate bone and liver isoenzymes more effectively than starch gel electrophoresis. The liver position of every subject was seen as the fastest moving compact band and had relatively low heat inactivation, whereas the bone band was slower, less compact, and had a high heat inactivation. The intestinal position was easily observed on starch gel electrophoresis, and was visualized on acrylamide gel by the subsequent use of the liver and bone inhibitor, L-homoarginine, in the substrate medium. These results show the heterogeneity of alkaline phosphatase isoenzymes in the serum of the normal individual.
Characterisation, cloning and sequencing of a conformation-dependent monoclonal antibody to the α IIb β 3 integrin: interest for use in thrombus detection

The detection of newly formed thrombi is of primary importance in clinical medicine. The activated platelet is a potential target for the localization of thrombotic lesions in arteries. The integrin f IIb g 3 membrane changes conformation upon activation. A novel anti- f IIb g 3 monoclonal antibody (MAb), XIIF9, is described which recognizes an epitope whose expression was enhanced by activation. Radioiodinated XIIF9 bound to a single class of sites on the g 3 subunit, with 13600 - 2000 molecules bound per unstimulated platelet and a K d of 34.5 nM. Platelets stimulated with 0.5 U/ml of thrombin bound 66000 - 4000 molecules/cell ( K d = 51.6 nM). Moreover, XIIF9 binding to unstimulated platelets could be increased 4-fold by treatment of the f IIb g 3 complex with 5 mM EDTA. Thus, XIIF9 recognized an epitope on the g 3 subunit whose accessibility was increased upon thrombin activation or EDTA treatment. Sequence analysis of the gene segment encoding the XIIF9 heavy chain revealed interesting motifs shared with cyclic CX6-7C anti- f IIb g 3 peptides or with AC7, a published MAb specific for activated f IIb g 3 . In vivo experiments in atherosclerotic rabbits followed by immunohistological analysis, revealed a specific binding of XIIF9 on platelets engaged in thrombus formation, demonstrating real clinical potential for such MAbs in imaging.
Errors of phase and group delays in SAW RFID with phase modulation

In order to obtain the exact time delay of pulses in the surface acoustic wave (SAW) based radio frequency identification (RFID) at unknown temperature, we propose a method for obtaining a high phase ambiguity resolution by measuring group delays and constructing some restriction on the exact positions of reflectors. To define the restriction parameters for a SAW RFID system with large code capacity and reliable identification, it is imperative to have a priori knowledge on the errors of group delay and phase. In this paper, we present the experimental and simulation errors for both phases and group delay, originated from the design procedure, the temperature effect, the fabrication process and the measurement. The temperature range in our investigation is -5deg -45degC. The average error of phase delay is about 4deg; the maximum error of phase delay is about 16deg. The maximum error of group delay is about 10 periods.
Swarm Intelligence Approach to Minimize the Transmission Line Losses

the real power transfers by maintaining voltage stability and system reliability. It is a critical element for a transmission operator to ensure the reliability of an electric system while minimizing the cost associated with it. Optimum scheduling of reactive power reduces the active power losses in the transmission system.This paper presents a Particle Swarm Optimization algorithm for Reactive Power Optimization problem. In this paper, reactive power optimization function is taken to minimize the real power losses. This paper covers the reactive power optimization problems, different optimization techniques, the basic concept of Particle Swarm Optimization and its algorithm for this problem and results obtained for 6-bus test system and IEEE 30-bus test system for PSO and Newton method. During the steady state operation of an AC power system the active power production must match the consumption plus the losses, otherwise the frequency will change. There is an equally strong relationship between the reactive power balance of a power system and the voltages. In itself, a reactive power balance will always inherently be present, but with an unacceptable voltages if the balance is not appropriate. An excess of reactive power in an area means high voltages and a deficit means low voltages. The reactive power balance of a power system also influences the active losses of the network, the heating of components and in some cases, the power system stability. Reactive power optimization is a sub-problem of the optimal power-flow (OPF) calculation, which determines all kinds of controllable variables, such as reactive power outputs of generators, tap ratios of transformers, outputs of shunt capacitors/reactors, etc., and minimizes transmission losses or other appropriate objective functions, while satisfying a given set of physical and operating constraints.
Glutaraldehyde Treated Autologous Pericardium in Complete Repair of Tetralogy of Fallot

Pericardium has been used for decades to facilitate the repair of tetralogy of Fallot (TOF). The Impact of glutaraldehyde preserved autologous pericardium when used as a right ventricular outflow tract (RVOFT) patch in TOF was analyzed in 36 consecutive children undergoing complete transventricular repair. In 18 (group 1) the pericardium was treated in conventional fashion (harvested and preserved in saline solution). In the other patients, the pericardium was treated in 0.625% glutaraldehyde solution for 20 minutes and then washed In saline prior to being implanted as an RVOFT patch (group II). The perioperative (prior to hospital discharge) as well as the 6‐month postoperative Doppler echocardiograms were assessed with 100% follow‐up. The studies were evaluated and graded by blinded observers for the presence and severity of an RVOFT dilatation (+0 to +4) relative to the size of the aortic valve annulus. The age of patients in group I and group II (29 months, 34 months) were similar as was the incidence of transannular patching (44%, 41%). Postrepair hernodynamics revealed no significant difference in the right ventricular/left ventricular pressure ratios (42%, 41%,) or in the systolic RVOFT pressure (24 mmHg, 29 mmHg). The predischarge echocardiograms showed no outflow tract (OFT) dllation in either group. There was no morbidity or mortality in either group. At approximately 6 months postoperatively (6.2 mo, 5.7 mo), 72% of group I patients had RVOFT diameters that were larger (+1, +2) than the predischarge diameters when reviewed by three observers. In group II there was a single patient with dilatation of the RVOFT and this graded as +1. The mean RVOFT dilation score in group I was 1.06 (+0.8) versus 0.06 (+0.24) in group II (p < 0.05). We conclude that dilute glutaraldehyde preservation of autologous pericardium is a safe and effective means of preventing RVOFT dilatation over the short term in patients in which a hemodynamically acceptable repair of TOF has been completed. (J Card Surg 1994;9:298–303)
The stochastic interpolation method: A simple scheme to prove replica formulas in Bayesian inference

In recent years important progress has been achieved towards proving the validity of the replica predictions for the (asymptotic) mutual information (or "free energy") in Bayesian inference problems. The proof techniques that have emerged appear to be quite general, despite they have been worked out on a case-by-case basis. Unfortunately, a common point between all these schemes is their relatively high level of technicality. We present a new proof scheme that is quite straightforward with respect to the previous ones. We call it the adaptive interpolation method because it can be seen as an extension of the interpolation method developped by Guerra and Toninelli in the context of spin glasses, with an interpolation path that is adaptive. In order to illustrate our method we show how to prove the replica formula for three non-trivial inference problems. The first one is symmetric rank-one matrix estimation (or factorisation), which is the simplest problem considered here and the one for which the method is presented in full details. Then we generalize to symmetric tensor estimation and random linear estimation. We believe that the present method has a much wider range of applicability and also sheds new insights on the reasons for the validity of replica formulas in Bayesian inference.
Characterization and transcriptional analyses of cDNAs encoding three trypsin‐ and chymotrypsin‐like proteinases in Cry1Ab‐susceptible and Cry1Ab‐resistant strains of sugarcane borer, Diatraea saccharalis

Diatraea saccharalis is a major corn borer pest. Midgut serine proteinases are essential for insect growth and development. Alteration of midgut proteinases is responsible for Bt resistance development in some species. To clone midgut trypsin and chymotrypsin cDNAs and to test if the Cry1Ab resistance in D. saccharalis is associated with changes in midgut proteinases, total midgut tryptic and chymotryptic activities, cDNA sequences, and gene expressions of three trypsin and three chymotrypsin genes were comparatively examined between Cry1Ab‐susceptible (Cry1Ab‐SS) and Cry1Ab‐resistant (Cry1Ab‐RR) strains. Full‐length cDNAs encoding three trypsin‐ and three chymotrypsin‐like proteinases were sequenced from Cry1Ab‐SS and Cry1Ab‐RR larvae. These cDNAs code for active forms of midgut serine proteinases with all functional motifs, including signal peptide, conserved His‐Asp‐Ser for the catalytic triad, three pairs of cysteines for disulfide bridge configurations, and conserved substrate specificity determination residues. In general, cDNA and putative protein sequences are highly similar between Cry1Ab‐SS and Cry1Ab‐RR strains, except for a few nucleotide and predicted amino acid substitutions, whose function need to be further clarified. Total trypsin and chymotrypsin activities were also similar between Cry1Ab‐SS and Cry1Ab‐RR strains. Transcriptional levels of the trypsin and chymotrypsin genes had numerical difference between Cry1Ab‐SS and Cry1Ab‐RR strains, but the difference was not statistically significant. Data suggest that the development of Cry1Ab resistance in D. saccharalis was not significantly associated with these trypsins and chymotrypsins. Results clarified the role of six midgut proteinases and provided a foundation for continuing examination of potential involvement of other midgut proteinases in Bt resistance development and other important biochemical processes.
Molecular-dynamics simulations of atomic-scale friction of diamond surfaces.

The friction which occurs when two diamond (111) hydrogen-terminated surfaces are placed in sliding contact is investigated for sliding in different crystallographic directions, as a function of applied load, temperature, and sliding velocity. We find a directional dependence to the friction coefficient, μ; that for certain crystallographic sliding directions μ increases with increasing load and as the temperature decreases; and that for the sliding speeds investigated here, μ is approximately independent of sliding velocity
Knockdown of NBCe1 in vivo compromises the corneal endothelial pump.

PURPOSE To evaluate the role of the sodium bicarbonate cotransporter (NBCe1) as a component of the corneal endothelial pump in the in vivo rabbit eye. METHODS Lentiviruses with NBCe1 shRNA and GFP expression cassettes were injected intracamerally. Knockdown efficacy was determined 1 week to 4 weeks later by immunofluorescence, Western blot analysis, and PCR. Functional effects were monitored by corneal thickness (CT) and brinzolamide sensitivity. RESULTS Within 24 hours there was a modest anterior chamber inflammation that resolved within 48 hours. At 4 × 10(6) IFU, more than 95% of the corneal endothelial surface showed GFP fluorescence above background within 7 days. At 14 to 21 days, signs of anterior chamber inflammation reemerged, and endothelial cell GFP fluorescence disappeared within 40 days after injection. The second phase of inflammation could be avoided by using GFP-less viruses. There was no significant difference in CT between scrambled sequence and NBCe1 shRNA-injected eyes over 3 weeks. Two drops of 1% brinzolamide produced 7.85% ± 3.3% corneal swelling within 5 hours of topical instillation. However, in corneas showing more than 25% NBCe1 knockdown (30 of 42 rabbits; 59% ± 15% knockdown), corneal swelling was significantly higher (10.1% ± 2.9%) relative to control eyes. CONCLUSIONS FIV-based lentiviral vectors can transfect CE with shRNA in rabbits. The response to GFP is consistent, with previous studies showing the production of anti-GFP antibodies. Partial knockdown of NBCe1 did not affect baseline CT, which is consistent with the corneal endothelium having a substantial functional reserve. Provocative testing using, brinzolamide, however, revealed an underlying deficiency, confirming the importance of NBCe1 bicarbonate transport and demonstrating the concerted action between NBCe1 and carbonic anhydrases.
Ionized Gas Outflows from the MAGNUM Survey: NGC 1365 and NGC 4945

AGN feedback, acting through strong outflows accelerated in the nuclear region of AGN hosts, is invoked as a key ingredient for galaxy evolution by many models to explain the observed BH-galaxy scaling relations. Recently, some direct observational evidence of radiative mode feedback in action has been finally found in quasars at $z$>1.5. However, it is not possible to study outflows in quasars at those redshifts on small scales ($\lesssim$100 pc), as spatial information is limited by angular resolution. This is instead feasible in nearby active galaxies, which are ideal laboratories to explore outflow structure and properties, as well as the effects of AGN on their host galaxies. In this proceeding we present preliminary results from the MAGNUM survey, which comprises nearby Seyfert galaxies observed with the integral field spectrograph VLT/MUSE. We focus on two sources, NGC 1365 and NGC 4945, that exhibit double conical outflows extending on distances >1 kpc. We disentangle the dominant contributions to ionization of the various gas components observed in the central $\sim$5.3 kpc of NGC 1365. An attempt to infer outflow 3D structure in NGC 4945 is made via simple kinematic modeling, suggesting a hollow cone geometry.
Interaction quality between IS professionals and users: impacting conflict and project performance

The quality of the interaction between the information system project team and the users in a development project is not clearly linked to the success of projects in terms of meeting budgets and product goals. Quality interaction may be crucial in understanding why past research is equivocal in support of the development maxim that user involvement is crucial to the success of an information system project. In this study, internal conflict among the IS project team is separated from the conflict of project team members with external users. Both internal and external team conflicts are found to impact interaction quality negatively, which in turn is strongly and positively related to project performance. These relationships indicate that attention to both internal and external conflict is crucial in achieving project goals.
Rating Prediction with Topic Gradient Descent Method for Matrix Factorization in Recommendation

In many online review sites or social media, the users are encouraged to assign a numeric rating and write a textual review as feedback to each product that they have bought. Based on users’ history of feedbacks, recommender systems predict how they assesses the unpurchased products to further discover the ones that they may like and buy in future. A traditional approach to predict the unknown ratings is matrix factorization, while it uses only the history of ratings included in the feedbacks. In recent researches, its ignorance of textual reviews is pointed out to be the drawback that brings mediocre performance. In order to solve such issue, we propose a method of rating prediction which uses both the ratings and reviews, including a new first-order gradient method for matrix factorization, named Topic Gradient Descent (TGD). The proposed method firstly derives the latent topics from the reviews via Latent Dirichlet Allocation. Each of the topics is characterized by a probability distribution of words and is assigned to correspond to a latent factor. Secondly, to predict the ratings of the users, it uses matrix factorizaiton which is trained by the proposed TGD method. In the training process, the updating step of each latent factor is dynamically assigned depending on the stochastic proportion of its corresponding topic in the review. In evaluation, we both use YELP challenge dataset and per-category Amazon review datasets. The experimental results show that the proposed method certainly converges the squared error of the prediction, and improves the performance of traditional matrix factorization up to 12.23%.
DESENVOLVIMENTO DOS TRANSPORTES E INTEGRAÇÃO REGIONAL NO BRASIL — UMA PERSPECTIVA HISTÓRICA

O trabalho examina a evolucao da percepcao do isolamento nacional como um problema de politica publica, e faz consideracoes sobre diversos planos, projetos e tentativas de se construir uma infra-estrutura de transportes no pais, com obje-tivos integracionistas e de modernizacao da economia nacional. Sua ideia basica e a de mos-trar por que a integracao das varias regioes brasileiras foi um processo lento, e por que o pais ingressou na era moderna do seu desenvolvimento sem contar com um sistema nacional de transportes multimodais e dependendo tao largamente da rodovia para a movimentacao de cargas e de passageiros.
Parallelize the Runtime Checks -- Not the Application

Sequential and parallel applications are both prone to security and dependability bugs. Compilers can reduce the impact of these bugs by instrumenting runtime checks into the generated code. These runtime checks can have a dramatic negative impact on the performance of an application. For instance, our measurements show that compiler generated array-bounds checks can increase the application’s runtime by 20x. To make compiler generated checks practically usable, the introduced application slowdowns must be decreased. Single thread performance is only expected to grow slowly. To compensate these single thread slowdowns, it is very desirable to parallelize checked applications and/or their runtime checks. In this paper, we provide evidence that it is more promising to parallelize the runtime checks than the application: We therefore compare two frameworks using two different parallelization approaches: (1) parallelizing the application together with the runtime checks, and (2) parallelizing only the runtime checks. We focus on two frameworks that were developed in our group: Tanger The first implementation is the compiler extension Tanger [2] for software transactional memory (STM). Tanger puts every memory access within transactions under the control of the TinySTM++ library [3]. To apply this approach, an application must be parallelizable with transactional memory. ParExC ParExC (Parallel Execution Checking) parallelizes the runtime checks but not the application itself. Therefore, it is also suited for applications that are difficult to parallelize. ParExC executes the application without any runtime checks in the so called predictor process. The predictor’s execution is partitioned into epochs. Each epoch is replayed by an executor process, but this time with runtime checks. We scale by running the executors in parallel to each other and the predictor. Like Speck [5], ParExC allows a fast execution of the application by speculating on the success of the runtime checks. Speck parallelizes using dynamic binary instrumentation. Unlike Speck, ParExC parallelizes compiler generated checks at compile time. Roadmap In Sections 2 and 3, we introduce the two approaches in more details. Our experiments in Section 4 show that the specialized ParExC approach scales better than applications instrumented by Tanger for a checker with heavy runtime overhead if at-most 8 cores are available.
The 5-HT2A –1438 A/G and 5-HTTLPR Polymorphisms and Personality Dimensions in Adolescent Anorexia Nervosa: Association Study

Disturbances of serotonergic neurotransmission and temperamental vulnerability have both been implicated in the pathogenesis of anorexia nervosa (AN). We genotyped the –1438 A/G polymorphism in the 5-HT2A receptor gene and serotonin transporter linked-polymorphic region (5-HTTLPR) in 132 adolescent subjects with AN and in 93 healthy controls. Personality dimensions in AN patients were assessed with the Temperament and Character Inventory. In a case-control model, we tested the hypothesis that these genetic variants confer susceptibility to AN. We also analyzed whether two polymorphisms show association with temperamental and character traits. No significant difference was found in the 5-HTTLPR frequency between AN patients and controls; however, there was a statistical trend towards a higher frequency of the A allele of the –1438 A/G polymorphism in patients than in controls (64.9 vs. 56.7%, χ2 test, p = 0.08). We also found a significant association between the A allele of this polymorphism and two temperamental traits. Patients homozygous for the A allele showed lower reward dependence than G/G homozygotes, and A/A homozygotes showed lower harm avoidance than heterozygotes. Low reward dependence and harm avoidance were more characteristic of the restrictive-type AN than of other subtypes of the disorder. No association of 5-HTTLPR with personality dimensions in AN patients was observed. Our results may suggest that the A allele of the –1438 A/G polymorphism confers some genetic risk for adolescent AN patients, especially in those with personality traits, which are typical of the restrictive-type AN.