Miracle-dz/UniFAR-FTUs huggingface dataset:
Global and Extended Coagulation Monitoring during Extracorporeal Lung Assist with Heparin-Coated Systems in ARDS Patients

Heparin-coated systems for extracorporeal lung-assist (ECLA) were developed to reduce hemorrhagic risk by lowering the systemic heparinization, monitored by global tests, e.g. activated coagulation time (ACT) and activated partial thromboplastin time (APTT). Since this strategy gives no insight into procoagulant states, five ARDS patients receiving ECLA with heparin-coated systems were investivated for changes in coagulation using both global and extended tests. During ECLA onset the APTT and ACT were within or near normal ranges, platelets decreased 76.5% within 48h, fibrinogen decreased 28.7%, thrombin-antithrombin-III complexes were elevated before ECLA (53 μg/L), but demonstrated an additional peak (238 μg/L), plasminogen-activator-inhibitor-1 increased 12-fold, and the C1-inhibitor dropped 14.1%. In conclusion, after the onset of ECLA from a previous prethrombotic state, the precoagulant, anticoagulant, fibrinolytic and complement systems were activated in a similar way to that reported for non-heparinized systems with high-dose heparin. This was however only monitored by an extended test panel which was unable to predict thromboembolic events during ECLA.
Nursing Home Deficiencies: An Exploratory Study of Interstate Variations in Regulatory Activity

ABSTRACT This study examines nursing home regulatory activity by the states, assesses interstate variations in the volume and severity of nursing home deficiencies, and explores state-level factors that may account for these differences. Nursing home deficiency citation data over a 5-year period (2000–2004) were obtained from the Centers for Medicare and Medicaid Services. We examined interstate variations in regulatory activity and identified predictors of deficiency volume and severity at the state level (demographics, elected officials, industry characteristics, etc.) using the linear mixed model. Deficiency volume remained stable across the 50 states from 2000 to 2004, while deficiency severity decreased significantly. California had the highest volume of deficiencies per nursing home; Wisconsin had the lowest. New Hampshire had the highest percentage of severe deficiencies; California had the lowest. Higher deficiency volume was found in states with lower median household income, a lower proportion of residents aged 85 and older, and a Democratic legislature. Higher deficiency severity was associated with higher median household income and a higher proportion of Medicaid nursing home residents in a state. In contrast, greater state agency funding, higher state standards for nursing home administrators, and a Democratic and more professional legislature predicted lower deficiency severity. Nursing home residents in the United States receive unequal protection from abuse and neglect, and this is partly due to their state of residence. Interstate variations in deficiency volume and severity are due to a complex set of factors beyond nursing home quality.
Women And Men In Entrepreneurship

This paper of female entrepreneurship has been inspired by gender equality issues. Today research and policy have been more and more fuelled by the idea that female entrepreneurs are important for economic progress. Female entrepreneurs were assumed to experience gender-related discrimination and to experience more difficulties when starting up and running a business than their male counterparts. Even when issues such as barriers and obstacles to female entrepreneurs are raised in the gender and entrepreneurship debate, this is usually done from the perspective that female entrepreneurs are an untapped resource and have potential to contribute to a country’s economic performance. Indeed, although gender equality is one of the arguments underlying the support for female entrepreneurs within the European Union, the argument that female entrepreneurs (have the potential to)contribute to economic performance continues to play a role here. The global growth of female entrepreneurship in the last decades has been accompanied by an increase in the number of studies on female entrepreneurship.
Cerebral Amyloid Angiopathy or Frontotemporal Dementia? A Case Study

A 67 year old patient developed progressive behavioral abnormalities and executive dysfunction corresponding to the diagnosis of behavioral variant of frontotemporal dementia (bvFTD). Unexpectedly, MRI showed multiple vascular ischemic and hemorrhagic lesions as typically found in sporadic cerebral amyloid angiopathy (SCAA). Based on clinical, laboratory and imaging findings the diagnosis of possible SCAA was made. SCAA may represent another important differential diagnosis among the various underlying disease pathologies of the bvFTD syndrome.
A UHF voltage multiplier circuit using a threshold-voltage cancellation technique

The operating range of passive UHF transponder systems is largely determined by the tag current consumption and the rectifier efficiency. Reading ranges of several meters have recently been reported for many state of the art RFID (Radio frequency IDentification) tags [1]. At this distance, the main issue for the rectifier design is the low amplitude of the high frequency antenna signal. Schottky diodes are often used for their low forward voltage drop and high switching speed. As an alternative to Schottky diodes, different circuit techniques for compensating the threshold voltage of standard transistor diodes have been utilized [4]. The transistor gates are biased near the threshold voltage, so that the devices effectively act as diodes with very low forward voltage drop. In the presented rectifier, a secondary diode charge pump is used to generate the DC bias for the threshold voltage compensation. The circuit is implemented in a standard CMOS technology and operates at a minimum available power of −11.3 dBm for an output DC power of 7.5 µW.
Comparative study of affective disorders in three Asian countries I. Differences in diagnostic classification

A study aimed at the standardization of symptom evaluation of patients with depression was carried out as the first step in an extensive collaborative study on affective disorders between centers in Nagasaki, Shanghai and Seoul. This study was initiated in order to clarify the factors affecting the low reported prevalence rates of depressive disorders in Asia. No significant difference in evaluation of psychiatric symptoms was observed between the 3 centers. Nevertheless, the diagnoses given by ICD‐9 showed very interesting differences. For any given case, Nagasaki tended to make a diagnosis of an affective psychosis depression, while Shanghai made a diagnosis of neurotic disorder. No significant tendency was observed in the Seoul center. These findings are discussed in terms of their importance for future international collaborative studies.
Asset Pricing and Truth

Truth is important in finance. Asset valuation, being a constitutive component of investment theory and the allocation of resources in the industry of financial services, is based on models that calculate true asset values as distinct from observed market prices. In financial economics, truth is essential in theoretical and empirical work in market microstructure, corporate finance and asset pricing. Drawing on theories of truth, this essay discusses what is meant by truth in asset valuation and provides an assessment of the diverse uses of “true values” in finance. The versatile use of true asset values is assessed in the context of those philosophical theories of truth which are most relevant to asset pricing debates: the correspondence theory of truth, the coherence theory as well as the pragmatist approach to truth. A key issue, common with all theories of truth, is that truth in asset valuation is not independent of the context of inquiry; it is always model-dependent. This finding motivates the argument that theory-independent reality should be explored on the level of structures that trigger market outcomes, rather than the level of asset values. Our findings on the context-dependent character of true asset values also necessitate the exploration of the structure of scientific inquiry in which some contexts prevail over others and some valuation models are widely adopted as measures of truth.
The Impact Of Fiscal Depreciation Over The Economic And Fiscal Performance Of The Company

Depreciation, together with net result, define self-financing capacity of the company and any movement at the depreciation generates inverse effects on profit tax. For this reason, the system of evaluation and depreciation of fixed assets should be coordinated with maintaining the capital. In the case of depreciation, accounting policy may concern choosing one of the methods of depreciation, for example linear depreciation, accelerated or diminishing. The choice of a method of depreciation involves an accountable option. Article presents a comparative approach of the methods of depreciation and its implications on the economic and fiscal performance of the company, but it all depends on the business objectives, the strategy and the fiscal management
Is there evidence that phonophoresis is more effective than ultrasound in treating pain associated with lateral epicondylitis?

The purpose of “Evidence in Practice” is to illustrate how evidence is gathered and used to guide clinical decision making. This article is not a case report. The examination, evaluation, and intervention sections are purposely abbreviated. A48-year-old woman was referred to our clinic with pain in the lateral epicondyle region of her right elbow. She is right-hand dominant. This pain started about 1 year ago, and the pain gradually increased throughout the past summer. During the warmer months she rides a motorcycle almost every day. The right hand is responsible for controlling the throttle of her motorcycle, and the wrist extensor muscles must contract to maintain active wrist extension for long periods of time. The right hand also controls the front brake lever, which is squeezed to apply the brake. This action also requires that the wrist extensor muscles contract to stabilize the wrist as the finger flexor muscles contract to squeeze the lever. The patient, therefore, uses her right wrist extensors continuously when riding a motorcycle, and these muscles might be overused during frequent or lengthy rides. For our patient, the duration of a ride depends upon her destination, with trips ranging from 30 minutes to 10 hours a day. During the winter months, the pain subsided. With the weather getting warmer, she resumed riding and was aware of a sudden increase in pain in the posterolateral region of her right elbow. Applying the brake increased her pain immediately. She also noticed increased pain when picking up a coffee mug or carrying groceries in plastic bags. She has tried to manage her pain conservatively with oral nonprescription analgesics and ice massage, but her pain has worsened considerably over the past 2 weeks. She was referred to our clinic after consulting with a physician for possible treatment. Examination revealed pain …
Increased protein secretion and adherence to HeLa cells by Shigella spp. following growth in the presence of bile salts

Growth of Shigella spp. in the presence of the bile salt deoxycholate or chenodeoxycholate enhanced the bacterial invasion of HeLa cells. Growth in the presence of other structurally similar bile salts or detergents had little or no effect. Deoxycholate-enhanced invasion was not observed when bacteria were exposed to deoxycholate at low temperatures or when chloramphenicol was added to the growth medium, indicating that bacterial growth and protein synthesis are required. Increased invasion is associated with the presence of an intact Shigella virulence plasmid and is correlated with increased secretion of a set of proteins, including the Ipa proteins, to the outer membrane and into the growth medium. The increased invasion induced by the bile salts appears to be due to increased adherence. The enhanced adherence was specific to Shigella spp. , since the enteroinvasive Escherichia coli strains tested did not exhibit the effect in response to growth in bile salts.
Protein diffusion in photopolymerized poly(ethylene glycol) hydrogel networks

In this study, protein diffusion through swollen hydrogel networks prepared from end-linked poly(ethylene glycol)-diacrylate (PEG-DA) was investigated. Hydrogels were prepared via photopolymerization from PEG-DA macromonomer solutions of two molecular weights, 4600 Da and 8000 Da, with three initial solid contents: 20, 33 and 50 wt/wt% PEG. Diffusion coefficients for myoglobin traveling across the hydrogel membrane were determined for all PEG network compositions. The diffusion coefficient depended on PEG molecular weight and initial solid content, with the slowest diffusion occurring through lower molecular weight, high-solid-content networks (Dgel = 0.16 ± 0.02 × 10−8 cm2 s−1) and the fastest diffusion occurring through higher molecular weight, low-solid-content networks (Dgel = 11.05 ± 0.43 × 10−8 cm2 s−1). Myoglobin diffusion coefficients increased linearly with the increase of water content within the hydrogels. The permeability of three larger model proteins (horseradish peroxidase, bovine serum albumin and immunoglobulin G) through PEG(8000) hydrogel membranes was also examined, with the observation that globular molecules as large as 10.7 nm in hydrodynamic diameter can diffuse through the PEG network. Protein diffusion coefficients within the PEG hydrogels ranged from one to two orders of magnitude lower than the diffusion coefficients in free water. Network defects were determined to be a significant contributing factor to the observed protein diffusion.
A generalised wavelet modulation scheme for single-phase inverters

More recently, a completely different and a promising PWM switching method, based on wavelet modulation (WM) has been reported for single phase inverters. The WM scheme has been tested with single-phase inverters; higher magnitudes of fundamental components and lower harmonic contents than those from the conventional PWM and Random PWM inverters are reported. However, a major problem with WM scheme, in its present form, is that it does not provide complete control on inverter output voltage. The existing WM scheme, in its present form, cannot fully control inverter output voltage magnitude. Contrary to the existing WM method, the method proposed in this paper, termed as generalised wavelet modulation (GWM) scheme is capable of producing wide range of variable magnitude and frequency fundamental voltages at inverter output without indulging any extra computational burden. The proposed GWM scheme of four pulse single phase inverter presented in the paper is implemented using a MATLAB code, and is finally converted to an equivalent SIMULINK block. Extensive simulations have been carried out on single phase voltage source inverter using the developed SIMULINK block to analyse the performance of the proposed scheme at different switching frequencies and for a wide range of inverters output voltage magnitudes.
Increased calcium entry into dystrophin‐deficient muscle fibres of MDX and ADR‐MDX mice is reduced by ion channel blockers

1 Single fibres were enzymatically isolated from interosseus muscles of dystrophic MDX mice, myotonic‐dystrophic double mutant ADR‐MDX mice and C57BL/10 controls. The fibres were kept in cell culture for up to 2 weeks for the study of Ca2+ homeostasis and sarcolemmal Ca2+ permeability. 2 Resting levels of intracellular free Ca2+, determined with the fluorescent Ca2+ indicator fura‐2, were slightly higher in MDX (63 ± 20 nm; means ±s.d.; n= 454 analysed fibres) and ADR‐MDX (65 ± 12 nm; n= 87) fibres than in controls (51 ± 20 nm; n= 265). 3 The amplitudes of electrically induced Ca2+ transients did not differ between MDX fibres and controls. Decay time constants of Ca2+ transients ranged between 10 and 55 ms in both genotypes. In 50% of MDX fibres (n= 68), but in only 20% of controls (n= 54), the decay time constants were > 35 ms. 4 Bath application of Mn2+ resulted in a progressive quench of fura‐2 fluorescence emitted from the fibres. The quench rate was about 2 times higher in MDX fibres (3.98 ± 1.9% min−1; n= 275) than in controls (2.03 ± 1.4% min−1; n= 204). The quench rate in ADR‐MDX fibres (2.49 ± 1.4% min−1; n= 87) was closer to that of controls. 5 The Mn2+ influx into MDX fibres was reduced to 10% by Gd3+, to 19% by La3+ and to 47% by Ni2+ (all at 50 μm). Bath application of 50 μm amiloride inhibited the Mn2+ influx to 37%. 6 We conclude that in isolated, resting MDX muscle fibres the membrane permeability for divalent cations is increased. The presumed additional influx of Ca2+ occurs through ion channels, but is well compensated for by effective cellular Ca2+ transport systems. The milder dystrophic phenotype of ADR‐MDX mice is correlated with a smaller increase of their sarcolemmal Ca2+ permeability.
The condensing engine: A heat engine for operating temperatures of 100 ℃ and below

The cost-effective utilisation of low-grade thermal energy with temperatures below 150 ℃ for electricity generation still constitutes an engineering challenge. Existing technology, e.g. the organic Rankine cycle machines, are complex and only economical for larger power outputs. At Southampton University, the steam condensation cycle for a working temperature of 100 ℃ was analysed theoretically. The cycle uses water as working fluid, which has the advantages of being cheap, readily available, non-toxic, non-inflammable and non-corrosive, and works at and below atmospheric pressure, so that leakage and sealing are not problematic. Steam expansion will increase the theoretical efficiency of the cycle from 6.4% (no expansion) to 17.8% (expansion ratio 1:8). In this article, the theoretical development of the cycle is presented. A 40 Watt experimental engine was built and tested. Efficiencies ranged from 0.02 (no expansion) to 0.055 (expansion ratio 1:4). The difference between theoretical and experimental efficiencies was attributed to significant pressure loss in valves, and to difficulties with heat rejection. It was concluded that the condensing engine has potential for further development.
The Irrigation Water Rental Market: A Case Study

Research on the market for irrigation water has been initiated to examine the institutional arrangements that have developed in certain areas to make irrigation water more readily transferable between farmers who have varying seasonal needs for water. This article outlines the manner and extent that farmers and irrigation companies in the South Platte Basin have developed arrangements for transferring water during a single crop season.
Bacterial utilization of dissolved free amino acids, dissolved combined amino acids and ammonium in the Delaware Bay estuary: effects of carbon and nitrogen limitation

The contribution of dissolved free amino acids (DFAA), dissolved combined amino acids (DCAA) and ammonium to the C and N requirements of bacterioplankton was examined in batch cultures enriched with various sources of C and N. DFAA sustained up to 14 and 34% of the C and N requirements, respectively, during exponential growth. DCAA constituted less than 10% of the C demand in all cultures during exponential growth and up to 24 % of the N demand in N-limited cultures. In C-limited cultures DFAA. DCAA. and NH,+ constituted 3 7 to 62%. 4 to 10% and 27 to 59% of total N uptake (DFAA + DCAA + NH,+) during exponential growth. In nitrogen-limited cultures the corresponding values were 78, 14, and 8 % of total N uptake. During the stationary phase the importance of DCAA as a C and N source increased as DFAA and NH,+ concentrations decreased. In addition to allowing us to examine the contribution of various compounds to supporting bacterial production, our data on uptake and concentrations suggest that bacteria release free and combined amino acids, especially during the stationary phase.
Image preprocessor of model-based vision system for assembly robots

A special purpose image preprocessor for the visual system of assembly robots has been developed. The main function unit is composed of look-up tables to utilize the advantage of semiconductor memory for large scale integration, high speed and low price. More than one units may be operated in parallel since it is designed on the standard IEEE 796 bus. The operation time of the preprocessor in line segment extraction is usually 200 ms per 500 segments, though it differs according to the complexity of scene image. The gray-scale visual system supported by the model-based analysis program using the extracted line segments recognizes partially visible or overlapping industrial workpieces, and detects these locations and orientations. In recognition test using plastic workpieces, the recognition time was about 9 seconds for five pieces. In most of conventional model-based vision systems, the feature extraction time was extremely longer than that of the model-based analysis. The image preprocessor we have developed reduces the time ratio of feature extraction and model-based analysis to about 1/10.
An automatic transient detection system which can be incorporated into an algorithm to accurately determine the fault level in networks with DG

The use of distributed generation is on the increase within the United Kingdom and the Distribution Network Operators (DNO's) require a novel approach of assessing potential fault levels in near “real-time” to assist with network planning and design. The short circuit current is the current expected to flow into a short circuit fault at a known point on the system, and therefore, the fault level is the product of the open circuit voltage and short circuit current. Recent techniques used by the industry involve power system software that calculates the fault level in accordance with BS EN 60909, however, this frequently provides a conservative answer and possibly this will be a factor restricting future connections of distributed generation. This paper will describe the initial stages of the development of an algorithm which can be used alongside a digital signal controller (a Texas Instruments TMS320F28335) to calculate in near “real-time” the fault level at a specified point on the distribution network. Matlab & Simulink are utilised to both simulate source faults and to create the initial elements of the algorithm which are analysed utilsing the test program. The implementation of a Short Time Fourier Transform (STFT) to determine when a fault occurs is discussed. Finally the results from these simulations are examined and presented alongside a discussion of future work.
BIOCHEMICAL ANALYSIS OF A PUBLIC H‐2 SPECIFICITY REVEALED BY AN ANOMALOUS REACTION OF AN ALLOANTISERUM WITH A CHEMICALLY INDUCED C57BL/10 FIBROSARCOMA

D‐25 is a H‐2 alloantiserum produced in (B10.D2 x C3H.NB) (H‐2d x H‐2p)F1 mice after immunization with B10.RIII(H‐2r) cells, and which is known to recognize the H‐2.25 public antigen on H‐2k haplotypes. The ‘anomalous’ reaction of D‐25 with a partially purified deoxycholate‐solubilized glycoprotein of B10‐1 (H‐2b) fibrosarcoma was studied with various biochemical techniques. The 125I‐labelled precipitates were analysed both in one‐ and two‐dimensional SDS‐PAGE and by a partial proteolysis peptide mapping (Cleveland's mapping). The results indicate first that the D‐25‐related antigen was a genuine H‐2 antigen normally associated with the B2‐microglobulin, second that this antigen was borne by the Kb but not Db gene products, and finally that D‐25 was able to precipitate the same antigen on normal H‐2b spleen cells. We conclude that this serum recognized a normal H‐2 specificity shared by H‐2b and H‐2r haplotypes and tentatively identified as the public antigen H‐2.54 which for the first time could be assigned to the K but not to the D region of the H‐2b haplotype.