Miracle-dz/UniFAR-FTUs huggingface dataset:
PHASE-SHIFTING DIFFRACTION INTERFEROMETER FOR INSPECTING NIF IGNITION-TARGET SHELLS

OVERVIEW OF THE DESIGN This paper describes the top-level design of a phase-shifting diffraction interferometer (PSDI) system for mapping the outer surface of small spherical parts (a shell), with emphasis on the PSDI head and the motion control system used to position it with respect to a shell. The method of operation of the PSDI, which consists of a laser front-end and an interferometer head, is described extensively elsewhere [1, 2, 3] and a brief description is included at the end of this paper. The interferometer head is adapted to an XYZ linear stage stack, and the shell to be measured is held by vacuum in a transfer chuck mounted to a Theta-Phi rotary stage stack (elevation-azimuth, relative to the shell). Figure 1 shows a model of this system, and Figure 2 shows a detail from that model.
3 D change detection – approaches and applications

Due to the unprecedented technology development of sensors, platforms and algorithms for 3D data acquisition and generation, 3D spaceborne, airborne and close-range data, in the form of image based, Light Detection and Ranging (LiDAR) based point clouds, Digital Elevation Models (DEM) and 3D city models, become more accessible than ever before. Change detection (CD) or time-series data analysis in 3D has gained great attention due to its capability of providing volumetric dynamics to facilitate more applications and provide more accurate results. The state-of-the-art CD reviews aim to provide a comprehensive synthesis and to simplify the taxonomy of the traditional remote sensing CD techniques, which mainly sit within the boundary of 2D image/spectrum analysis, largely ignoring the particularities of 3D aspects of the data. The inclusion of 3D data for change detection (termed 3D CD), not only provides a source with different modality for analysis, but also transcends the border of traditional top-view 2D pixel/object-based analysis to highly detailed, oblique view or voxel-based geometric analysis. This paper reviews the recent developments and applications of 3D CD using remote sensing and close-range data, in support of both academia and industry researchers who seek for solutions in detecting and analyzing 3D dynamics of various objects of interest. We first describe the general considerations of 3D CD problems in different processing stages and identify CD types based on the information used, being the geometric comparison and geometric-spectral analysis. We then summarize relevant works and practices in urban, environment, ecology and civil applications, etc. Given the broad spectrum of applications and different types of 3D data, we discuss important issues in 3D CD methods. Finally, we present concluding remarks in algorithmic aspects of 3D CD.
A METAMATERIAL DESCRIPTION OF A VOLUMETRIC ARTIFICIAL MAGNETIC CONDUCTOR

Several planar and volumetric metamaterial slabs have been investigated that act as artificial magnetic conductors (AMCs), i.e., that produce in-phase reflections. It has been found that a volumetric metamaterial constructed from a periodic arrangement of capacitively loaded loops (CLLs) acts as a PMC when the incident wave first interacts with the capacitor side of the CLLs and as a PEC from the opposite direction. The equivalent material model of the CLL-based AMC is shown to consist of a two time derivative material (2TDLM) model for the permittivity and a Drude model for the permeability. The resonance of the real part of the 2TDLM model and the zero crossing of the real part of the Drude model occur at the frequency, fcrit, for which the in-phase reflection occurs. This concurrence of the critical frequencies of both models produces a metamaterial slab with a high-Z state at fcrit. Numerical simulation and experimental results for the CLL-based metamaterial slab will be presented.
Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assay

Abstract We investigated the potential of four well-characterized amorphous silica nanoparticles to induce chromosomal aberrations and gene mutations using two in vitro genotoxicity assays. Transmission electron microscopy (TEM) was used to verify the manufacturer's nominal size of 10, 30, 80 and 400 nm which showed actual sizes of 11, 34, 34 and 248 nm, respectively. The 80 (34) nm silica nanoparticles induced chromosomal aberrations in the micronucleus assay using 3T3-L1 mouse fibroblasts and the 30 (34) and 80 (34) nm silica nanoparticles induced gene mutations in mouse embryonic fibroblasts carrying the lacZ reporter gene. TEM imaging demonstrated that the majority of nanoparticles were localized in vacuoles and not in the nucleus of 3T3-L1 cells, indicating that the observed DNA damage was most likely a result of indirect mechanisms. Further studies are needed to reveal these mechanisms and to determine the biological relevance of the effects of these particular silica nanoparticles in vivo.
ANXA 1 Ac 2-26 peptide reduces ID 1 expression in cervical carcinoma cultures

a Department of Biology, Institute of Biosciences, Letters and Science — IBILCE/UNESP, São José do Rio Preto, SP, Brazil b Department of Clinical Medical, Foundation Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo — FCFRP/USP, Ribeirão Preto, SP, Brazil c Department of Molecular, Biology Faculty of Medicine of São José do Rio Preto — FAMERP, São José do Rio Preto, SP, Brazil d Department of Biology and Animal Science, Faculty of Engineering of Ilha Solteira — FEIS/UNESP, Ilha Solteira, SP, Brazil
Title : Requirements and conceptual design of techniques and methods for trustworthy & agile operation of smart IoT systems

Copyright © 2018 by the ENACT consortium – All rights reserved. The research leading to these results has received funding from the European Community's H2020 Programme under grant agreement n° 780351 (ENACT). Title: Requirements and conceptual design of techniques and methods for trustworthy & agile operation of smart IoT systems Authors: Haroon Ahmed (CA), Nicolas Ferry (SINTEF), Smrati Gupta (CA), Stéphane Lavirotte (CNRS), Andreas Metzger (UDE), Victor Muntés (CA), Phu NGuyen (SINTEF), Alexander Palm (UDE), Andreas Reiss (CA), Marc Solé (CA), Jean-Yves Tigli (CNRS) Editors: Stéphane Lavirotte (CNRS), Jean-Yves Tigli (CNRS) Reviewers: Anne Gallon (Evidian), Eider Iturbe Zamalloa (Tecnalia) Identifier: Deliverable # D3.1 v1.5 Nature: Report Date: 31 October 2018 Status: Delivered Diss. level: Public
MyD88-Dependent Signaling Affects the Development of Meningococcal Sepsis by Nonlipooligosaccharide Ligands

ABSTRACT The Toll-like receptors (TLRs) and the adaptor myeloid differentiation factor 88 (MyD88) are important in the innate immune defenses of the host to microbial infections. Meningococcal ligands signaling via TLRs control inflammatory responses, and stimulation can result in fulminant meningococcal sepsis. In this study, we show that the responses to nonlipooligosaccharide (non-LOS) ligands of meningococci are MyD88 dependent. An isogenic LOS-deficient mutant of the serogroup C meningococcal strain FAM20 caused fatal disease in wild type C57BL/6 mice that was not observed in MyD88−/− mice. Fatality correlated with high proinflammatory cytokine and C5a levels in serum, high neutrophil numbers in blood, and increased bacteremia at 24 h postinfection in the wild-type mice. Infection with the parent strain FAM20 resulted in fatality in 100% of the wild-type mice and 50% of the MyD88−/− mice. We conclude that both LOS and another neisserial ligand cause meningococcal sepsis in an in vivo mouse model and confirm that meningococcal LOS can act via both the MyD88- dependent and -independent pathways, while the non-LOS meningococcal ligand(s) acts only via the MyD88-dependent pathway.
EVALUATION ON HEAT AND MATERIALS BALANCE OF CO 2 INVOLVED IN CONVERTER PROCESS FOR M-LCFECR PRODUCTION

During the production of Medium-Low Carbon Ferrochromium (M-LCFeCr) or Medium-Low Carbon Ferromanganese (M-LCFeMn) in converter process with introduction of oxygen, the oxidation reactions of main and tramp elements by oxygen are all exothermic reactions, hence lead to energy surplus in the production process. Essentially there are three practical strategies to deal with energy surplus:  Dilute the surplus energy by adding coolants.  Remove the surplus energy by blowing inert gases (like argon).  Neutralize the surplus energy by injecting part CO2. The first method is used frequently nowadays, but the additional coolants including silicochromium and MLCFeCr are costly and cause the temperature variation in a wide margin. The second way is not cost effective to remove small amount of heat by introducing the expensive argon. The last method could be moderate and worth to study. CO2 introduction is aimed to realize controlling the bath temperature flexibly because C+CO2=2CO is an endothermic reaction, enhancing the yield of Cr (Mn) because of its weaker oxidation ability, prolonging the life time of the converter lining because of less thermal shock. However, those advantages need to be proved by theoretical and experimental work. The heat and material balance calculation can provide a theoretical basis for the production practice with introduction of CO2 in converter process. The authors pay attention to this aspect with the aim to optimize the amount of CO2 and the materials requirements. The optimal ratio of CO2 and O2 for producing M-LCFeCr and M-LCFeMn with different carbon content has been determined.
Urban traffic control using a fuzzy multi-agent system

This paper presents a fuzzy multi-agent system for control of the traffic signals of an urban network, where the aim is to reduce the total average delay time of the vehicles. The large-scale traffic system is first divided into sub-areas and an agent, using a fuzzy controller, is considered for each sub-area. In order to develop the fuzzy rule bases for the agents, an extensive set of data is collected and the corresponding origin-destination (OD) matrices are calculated. The OD matrices are then clustered using a new clustering algorithm proposed in this paper. Finally, the resulting cluster centers, which are matrices of the same dimension as the OD matrices, are mapped to a 2-dimensional space and the corresponding triangular fuzzy sets are extracted. An optimal cycle plan is found for each fuzzy set and this way the fuzzy rule bases are constructed (the triangular fuzzy sets form the IF-parts and the optimal cycle plans form the THEN-parts). In a case study the proposed multi-agent control system is applied to a microscopic urban traffic network and the results are compared with a controller that applies optimal signal plans calculated by PASSER V. The results show that the proposed fuzzy multi-agent system outperforms the non-fuzzy control system, where the average delay time of the traveling vehicles is decreased by 19% using the multi-agent control system.
Vimentin Expressed on Mycobacterium tuberculosis-Infected Human Monocytes Is Involved in Binding to the NKp46 Receptor1

We previously showed that human NK cells used the NKp46 receptor to lyse Mycobacterium tuberculosis H37Ra-infected monocytes. To identify ligands on H37Ra-infected human mononuclear phagocytes, we used anti-NKp46 to immunoprecipitate NKp46 from NK cells bound to its ligand(s) on H37Ra-infected monocytes. Mass spectrometry analysis identified a 57-kDa molecule, vimentin, as a putative ligand for NKp46. Vimentin expression was significantly up-regulated on the surface of infected monocytes, compared with uninfected cells, and this was confirmed by fluorescence microscopy. Anti-vimentin antiserum inhibited NK cell lysis of infected monocytes, whereas antiserum to actin, another filamentous protein, did not. CHO-K1 cells transfected with a vimentin construct were lysed much more efficiently by NK cells than cells transfected with a control plasmid. This lysis was inhibited by mAb-mediated masking of NKp46 (on NK cells) or vimentin (on infected monocytes). ELISA and Far Western blotting showed that recombinant vimentin bound to a NKp46 fusion protein. These results indicate that vimentin is involved in binding of NKp46 to M. tuberculosis H37Ra-infected mononuclear phagocytes.
Purification of plant-derived anti-virus mAb through optimized pH conditions for coupling between protein A and epoxy-activated beads

The main goal of this research was to determine optimum pH conditions for coupling between protein A and epoxy-activated Sepharose beads for purification of monoclonal antibodies (mAbs) expressed in plants. To confirm the effect of pH conditions on purification efficacy, epoxy-activated agarose beads were coupled to protein A under the pH conditions of 8.5, 9.5, 10.5, and 11.5 (8.5R, 9.5R, 10.5R, and 11.5R, respectively). A total of 300 g of fresh leaf tissue of transgenic Arabidopsis expressing human anti-rabies mAb (mAbP) SO57 were harvested to isolate the total soluble protein (TSP). An equal amount of TSP solution was applied to five resin groups including commercial protein A resin (GR) as a positive control. The modified 8.5R, 9.5R, 10.5R, and 11.5R showed delayed elution timing compared to the GR control resin. Nano-drop analysis showed that the total amount of purified mAbPSO57 mAbs from 60 g of fresh leaf mass were not significantly different among 8.5R (400 μg), 9.5R (360 μg), 10.5R (380 μg), and GR (350 μg). The 11.5R (25 μg) had the least mAbPSO57. SDS–PAGE analysis showed that the purity of mAbPSO57 was not significantly different among the five groups. Rapid fluorescent focus inhibition tests revealed that virus-neutralizing efficacies of purified mAbPSO57 from all the five different resins including the positive control resin were similar. Taken together, both pH 8.5 and 10.5 coupling conditions with high recovery rate should be optimized for purification of mAbPSO57 from transgenic Arabidopsis plant, which will eventually reduce down-stream cost required for mAb production using the plant system.
Early divergence of mutational processes in human fetal tissues

Different mutational processes are active in the fetal intestine than in the fetal liver. A developing human fetus needs to balance rapid cellular expansion with maintaining genomic stability. Here, we accurately quantified and characterized somatic mutation accumulation in fetal tissues by analyzing individual stem cells from human fetal liver and intestine. Fetal mutation rates were about fivefold higher than in tissue-matched adult stem cells. The mutational landscape of fetal intestinal stem cells resembled that of adult intestinal stem cells, while the mutation spectrum of fetal liver stem cells is distinct from stem cells of the fetal intestine and the adult liver. Our analyses indicate that variation in mutational mechanisms, including oxidative stress and spontaneous deamination of methylated cytosines, contributes to the observed divergence in mutation accumulation patterns and drives genetic mosaicism in humans.
Dietary supplementation of black soldier fly (Hermetica illucens) meal modulates gut microbiota, innate immune response and health status of marron (Cherax cainii, Austin 2002) fed poultry-by-product and fishmeal based diets

The present study aimed to evaluate the dietary supplementary effects of black soldier fly (Hermetia illucens) (BSF) meal on the bacterial communities in the distal gut, immune response and growth of freshwater crayfish, marron (Cherax cainii) fed poultry-by-product meal (PBM) as an alternative protein source to fish meal (FM). A total of 64 marron were randomly distributed into 16 different tanks with a density of four marron per tank. After acclimation, a 60-days feeding trial was conducted on marron fed isonitrogenouts and isocalorific diets containing protein source from FM, PBM, and a combination of FM + BSF and PBM + BSF. At the end of the trial, weight gain and growth of marron were found independent of any dietary treatment, however, the two diets supplemented with BSF significantly (P < 0.05) enhanced haemolymph osmolality, lysozyme activity, total haemocyte counts, and protein and energy contents in the tail muscle. In addition, the analysis of microbiota and its predicted metabolic pathways via 16s rRNA revealed a significantly (P < 0.05) higher bacterial activity and gene function correlated to biosynthesis of protein, energy and secondary metabolites in PBM + BSF than other dietary groups. Diets FM + BSF and PBM + BSF were seen to be associated with an up-regulation of cytokine genes in the intestinal tissue of marron. Overall, PBM + BSF diet proved to be a superior diet in terms of improved health status, gut microbiota and up-regulated expression of cytokine genes for marron culture.
Clinical comparison between a percutaneous hydraulic pressure delivery system and balloon tamp system using high-viscosity cement for the treatment of osteoporotic vertebral compression fractures

OBJECTIVES: Osteoporotic vertebral compression fractures (OVCFs) affect the elderly population, especially postmenopausal women. Percutaneous kyphoplasty is designed to treat painful vertebral compression fractures for which conservative therapy has been unsuccessful. High-viscosity cement can be injected by either a hydraulic pressure delivery system (HPDS) or a balloon tamp system (BTS). Therefore, the purpose of this study was to compare the safety and clinical outcomes of these two systems. METHODS: A random, multicenter, prospective study was performed. Clinical and radiological assessments were carried out, including assessments of general surgery information, visual analog scale, quality of life, cement leakage, and height and angle restoration. RESULTS: Using either the HPDS or BTS to inject high-viscosity cement effectively relieved pain and improved the patients' quality of life immediately, and these effects lasted at least two years. The HPDS using high-viscosity cement reduced cost, surgery time, and radiation exposure and showed similar clinical results to those of the BTS. In addition, the leakage rate and the incidence of adjacent vertebral fractures after the HPDS treatment were reduced compared with those after treatment using the classic vertebroplasty devices. However, the BTS had better height and angle restoration abilities. CONCLUSIONS: The percutaneous HPDS with high-viscosity cement has similar clinical outcomes to those of traditional procedures in the treatment of vertebral fractures in the elderly. The HPDS with high-viscosity cement is better than the BTS in the treatment of mild and moderate OVCFs and could be an alternative method for the treatment of severe OVCFs.
Maximize relative entropy approach to power allocation for gaussian signal detection problem

We consider a detection problem for Gaussian signal model. It is well known that likelihood-ratio test (LRT) is the optimal local sensor decision for both Bayesian and Nayman-Pearson (NP) criteria for a binary hypotheses testing problem. In general, the threshold computation of LRT is computationally intractable because of the high-dimensional integral caused by the multisensor measurements. Thus, it is very difficult to compute the detection probability and average error probability (Pe) exactly. In this case, approximation approaches are necessary in real problems. In this paper, we use relative entropy between two density functions as the measure of detection performance to study the power allocation in detection of Gaussian signals. The objective problem is not a convex problem. By the enhanced Fritz John necessary conditions we prove the local optimal solution satisfies the KKT conditions and also show existence and uniqueness of Lagrange multiplier. Then by the quality of convex function we show that D(P1 ∥ P0) is a monotonically increasing function of tr(Σs). Finally, we give some optimal power allocation matrices in special signal channels. Numerical examples show that average error probability (Pe) of new method we proposed and ergodic method decreases monotonically with transmit power P.
Developing Efficient Techniques for Clustering and Degradation Analysis in Time Series Data

Time series data mining is one of the most studied and researched areas. This need in mining time series data is engendered by proliferation of ubiquitous sensors collecting data on different aspects of our life, from measuring equipment parameters on chemical plants to counting heartbeats as we exercise. The hardware advances in recent years allow for producing large amounts of complex data to describe objects’ behaviors and changes in those behaviors.One of the most basic and widely used primitive for data mining is clustering, which finds its use as a subroutine in many higher-order algorithms. In the real world applications data often comes as a stream restricting random access to different data points and demanding to cluster coming data by processing each element only once. In this work, we propose a novel clustering algorithm for streaming data that can be used with any distance measure (not only metrics) and that is parameter-lite and exact. We demonstrate its utility on diverse real domains such as cardiology, entomology and biological audio processing.It was shown that for time series clustering it is often useful to ignore some data within each of the time series. A recently-proposed technique, u-shapelets, addresses this issue allowing us to consider only the relevant data for clustering. However, the original algorithms were intractable on large datasets. In this dissertation, we propose a speed-up technique that allows u-shapelet discovery up to two orders of magnitude faster than original algorithms without significant loss of clustering quality. We also demonstrate utility of our scheme on real datasets from diverse domains such as monitoring of physical activity of elderly people and bird song analysis.Finally, to allow monitoring of physical systems for aging and degradation signs, we propose a novel approach to extract and analyze the aging trend. Our algorithm can provide monitoring software with actionable information about the changes of the system’s behavior over time. This is critical to ensure timely repair of worn out components to maintain ceaseless work of the whole system.
Low Loss MEMS-Reconfigurable 1-Bit Reflectarray Cell With Dual-Linear Polarization

We present a X-band 1-bit reconfigurable reflectarray (RRA) cell capable of independent reflection phase control of each linear component of a dual-polarized wave. It presents the lowest loss ever reported in an operational RRA cell at microwave frequencies, thanks to particular design considerations and implementation in a monolithic micro-electromechanical systems (MEMS) process. The average reflection loss, including oblique incidence up to θ = 40°, is below 0.6 dB at the operating frequency. Low phase error and loss are preserved in a 12.5% bandwidth. Measurements demonstrate the viability of the concept as well as very good agreement between simulated and measured results.