Miracle-dz/UniFAR-FTUs huggingface dataset:
Widespread Expression of γ-Glutamyl Cyclotransferase Suggests It Is Not a General Tumor Marker

γ-Glutamyl cyclotransferase (GGCT) contributes to the γ-glutamyl cycle that regulates glutathione metabolism. Although GGCT has been implicated in several studies as a possible cancer marker, little is known about its distribution in cells and tissues. The authors investigated GGCT expression in normal tissues and tumors using Western blots and immunohistochemistry with a novel anti-GGCT monoclonal antibody. GGCT was detected in most organs and was mainly found in epithelial cells. Although the intracellular distribution was mainly cytoplasmic, in some situations, nuclear staining was strong. A significant increase in the expression of GGCT was found in tumors of the lung, esophagus, stomach, bile duct, and uterine cervix. In contrast, there was a significant decrease in expression in renal and urothelial tumors. These results suggest that GGCT may be a biomarker of tumors in a limited range of organs.
On the Use of Missing Feature Theory with Cepstral Features

Missing feature theory has been proposed as a solution for either ignoring or compensating the unreliable components of feature vectors corrupted mainly by bandlimited background noise. Since the corruption often occurs in the frequency domain, and it is smeared by the discrete cosine transform used to obtain cepstral features, algorithms utilizing the missing feature theory are usually restricted to spectral features. In many cases cepstral features might be preferable. We propose an algorithm for performing the missing feature operations in the frequency domain while utilizing standard Mel-cepstral features. The algorithm is based on transforming the cepstral difference operation into the Mel-spectrum domain, weighting (marginalizing) it there, and transforming it back into the cepstrum domain. The algorithm was tested in a German connected digit recognition system. Experimental results are shown first with artificially corrupted speech and then with speech corrupted using more realistic noise. While the results with data having clearly localized frequency domain corruption prove the viability of the proposed method, the results with car noise with more wideband-like characteristics were disappointing.
Molecular Characterization of Preintegration Latency in Human Immunodeficiency Virus Type 1 Infection

ABSTRACT Most current evidence suggests that the infection of resting CD4+ T cells by human immunodeficiency virus type 1 (HIV-1) is not productive due to partial or complete blocks in the viral life cycle at steps prior to integration of the viral genome into the host cell chromosome. However, stimulation of an infected resting T cell by antigen, cytokines, or microenvironmental factors can overcome these blocks and allow for the production of progeny virions. In this study, we sought to understand the structure and fate of the virus in unstimulated resting CD4+ T cells. Using a novel linker-mediated PCR assay designed to detect and characterize linear unintegrated forms of the HIV-1 genome, we demonstrate that reverse transcription can proceed to completion following the infection of resting T cells, generating the substrate for the retroviral integration reaction. However, reverse transcription in resting T cells is far slower than in activated T cells, requiring 2 to 3 days to complete. The delay in completing reverse transcription may make the viral DNA genome more susceptible to competing decay processes. To explore the relationship between the formation of the linear viral genome and the stability of the preintegration state, we employed a recombinant HIV-1 virus expressing the enhanced green fluorescent protein to measure the rate at which HIV-1 decays in the preintegration state. Our results demonstrate that the preintegration state is labile and decays rapidly (half-life = 1 day) following the entry of HIV-1 into a resting T cell, with significant decay occurring during the slow process of reverse transcription.
Performance analysis for voice/data integration on a finite-buffer mobile system

Personal communication service (PCS) networks offer mobile users diverse telecommunication applications, such as voice, data, and image, with different bandwidth and quality-of-service (QoS) requirements. This paper proposes an analytical model to investigate the performance of an integrated voice/data mobile network with finite data buffer in terms of voice-call blocking probability, data loss probability, and mean data delay. The model is based on the movable-boundary scheme that dynamically adjusts the number of channels for voice and data traffic. With the movable-boundary scheme, the bandwidth can be utilized efficiently while satisfying the QoS requirements for voice and data traffic. Using our model, the impact of hot-spot traffic in the heterogeneous PCS networks, in which the parameters (e.g., number of channels, voice, and data arrival rates) of cells can be varied, can be effectively analyzed. In addition, an iterative algorithm based on our model is proposed to determine the handoff traffic, which computes the system performance in polynomial-bounded time. The analytical model is validated by simulation.
Epicardial fat registration by local adaptive morphology-thresholding based 2D segmentation

3D heart registration has become an important issue in cardio vascular diagnosis and treatment. This is mainly due to advanced medical imaging technologies that provide significant amount of data with high precision. One of the important features of the heart that has recently drawn attention is epicardial fat (surrounds the heart), which according to some preliminary studies can be correlated well with risk prediction of various cardiovascular diseases. Consequently, automatic detection and registration of epicardial fat is considered as important task for medical doctors to include as additional feature within the already existing software for medical imaging and visualization. In this paper, we analyze heart images obtained by 4D CT technology and propose a segmentation scheme that automatically extracts epcardial fat in each 2D slice in order to perform 3D epicardial fat registration and visualization. The segmentation algorithm first enhances input image after which it performs patch based labeling and clustering of the selected features. The experimental results indicate good epicardial fat registration performance in comparison to manual segmentation obtained by the medical doctors.
Mode-Division Multiplexing Over 96 km of Few-Mode Fiber Using Coherent 6 $\,\times\,$6 MIMO Processing

We report simultaneous transmission of six spatial and polarization modes, each carrying 40 Gb/s quadrature-phase-shift-keyed channels over 96 km of a low-differential group delay few-mode fiber. The channels are successfully recovered by offline DSP based on coherent detection and multiple-input multiple-output processing. A penalty of <;1.2 dB is achieved by using 6 × 6 feed-forward equalizers with 120 taps each. The 6 × 6 impulse-response matrix fully characterizing the few-mode fiber is presented, revealing the coupling characteristics between the modes. The results are obtained using mode multiplexers based on phase plates with a mode selectivity of >;28 dB.
Pseudomonas aeruginosa bacteremia: resistance to antibiotics, risk factors, and patient mortality.

UNLABELLED The aim of our study was to determine the prevalence of Pseudomonas aeruginosa bacteremia, risk factors, and outcome of patients treated at the Hospital of Kaunas University of Medicine. MATERIAL AND METHODS All hospitalized patients with blood culture positive for Pseudomonas aeruginosa during the 5-year period were included. A retrospective data analysis was performed to evaluate patients' risk factors and mortality caused by P. aeruginosa bacteremia. RESULTS A total of 47 (58.8%) bacteremia episodes occurred in an intensive care unit (ICU). A primary source of bacteremia was identified in 50 (62.5%) episodes. Overall mortality rate was 58.8%. Univariate risk factors analysis showed the factors, which significantly increased the risk of death: mechanical ventilation (13.67 times, P<0.001), patient hospitalization in the ICU (8.51 times, P<0.001), acute respiratory failure (8.44 times, P<0.001), infection site in the respiratory tract (4.93 times, P=0.003), and central vein catheter (4.44 times, P=0.002). Timely and appropriate treatment and surgery were significant protective factors for 30-day mortality (11.1 and 5.26 times, respectively; P=0.001). Meropenem-resistant Pseudomonas aeruginosa strains caused bacteremia more frequently in patients older than 65 years than meropenem-sensitive strains (57.9%, n=11). All 19 patients with meropenem-resistant Pseudomonas aeruginosa bacteremia received inappropriate empirical antibiotic therapy. CONCLUSIONS Treatment at the intensive care unit, mechanical ventilation, acute respiratory failure, source of infection in respiratory tract, and central vein catheter are the major risk factors associated with an increased mortality rate in patients with Pseudomonas aeruginosa bacteremia. The patients older than 65 years are at increased risk for bacteremia caused by carbapenem-resistant Pseudomonas aeruginosa strains. Carbapenems are not antibiotics of the choice of treatment for Pseudomonas aeruginosa bacteremia at the Hospital of Kaunas University of Medicine.
Cytotoxic Characteristics and Sensitivities of Vero Cells Exposed to Organic Chemicals Pollutant and the Feasibilities in Bio-Toxicity Test of Drinking Water Concerning

The characteristics of morphological change of Mammalian Vero cells exposed to typical chemical pollutant 2, 4, 6-trichlorophenol (TCP) were studied, and its sensitivity and correlation were compared to that of cells proliferation inhibition tested by methylthiazol-2-yl-2, 5-diphenyl tetrazolium bromide (MTT) assay. The morphological change of Vero cell exposed to leachate from the Products Related to Drinking Water (PRDW) was also investigated, in order to test the reliability of this method to evaluate composite toxicity of trace chemicals in environment. The results showed that: 1) Less than 0.5 mg/l TCP already had some effects on cell morphology, and the proportion of morphology changed cells increased along with the elevation of TCP concentration. However, under the low TCP condition (less than 1.0 mg/1), the inhibition of cell proliferation tested by MTT Assay seemed to be irregular. 2) Exposed to the leachate of PRDW extracted at different temperature, the percentage of morphology changed cells increased with extracting temperature, but MTT assay failed to reflect the correlation between extracting temperature and proliferation inhibition of Vero cells. Therefore, the cell morphological changes should be a more sensitive and reliable method to indicate the composite bio-toxicity of trace chemicals than the proliferation inhibition, and its quantification should be studied further.
Effect of Prunus Tomentosa Thumb Total Flavone on hair growth

The preliminary laboratory study found that Prunus Tomentosa Thumb Total Flavone (PTTTF) had certain protection function on skin tissues and its subsidiary organs. Combined with civilian application experience, the study adopted C57BL 6 mouse phalacrosis models, the models were randomly divided into 5 groups with 10 in each group, namely: saline group (1 time / day), 70% ethanol group (1 time / day), PTTTF group I (1% PTTTF tincture, 1 time / day), 5% minoxidil tincture group (1 time / day) and PTTTF group II (1% PTTTF tincture, 2 times / day), with the PTTTF was used in external local parts continuously, the length mean of new hair was measured, meanwhile, the tissues of the phalacrosis zones were selected for pathological analysis. The results showed that PTTTF can prominently prolong the hair growth cycle, promote hair growth and promote follicle maturation. Tip: PTTTF has stronger role in promoting hair growth.
Pedagogik på social omsorgsgrund för personer med utvecklingsstörning

Huvudsyftet i avhandlingen ar, med utgangspunkt i samhallets styrdokument, att beskriva hur det kan vara att leva och bo i samhallet om man ar en vuxen person med utvecklingsstorning. Det ar av speciellt intresse att satta dessa personers livsvillkor i relation till begrepp som goda levnadsvillkor och att reflektera over deras chanser att fa en god fard genom livet.Forskningsmetoden har sin utgangspunkt i empowermentrorelsen, dar den enskildes maktgorande star i centrum.Avhandlingen speglar ytterst hur 17 personer med utvecklingsstorning, i tre olika grupper, samtalat med varandra om sina egna, levda livsprojekt. Utifran dessa samtal har sedan aktuella fragestallningar bearbetats - data har kategoriserats under begreppen kunskap, kansla och viljeyttring.Resultatet visar att dessa 17 manniskor erfarit fenomen som bland annat utanforskap, utsatthet, maktloshet, krankning och skam. Dessa begrepp bearbetades i relation till avhandlingens teoretiska ram, empowerment och fenomenologi.Avslutningsvis gors en reflektion over arbetssattets anvandbarhet och utveckling inom pedagogik pa social omsorgsgrund.
Non-supersymmetric conformal field theories from stable anti-de Sitter spaces

We describe new non-supersymmetric conformal field theories in three and four dimensions, using the CFT/AdS correspondence. In order to believe in their existence at large N_c and strong 't Hooft coupling, we explicitly check the stability of the corresponding non-supersymmetric anti-de Sitter backgrounds. Cases of particular interest are the relevant deformations of the N=4 SCFT in SU(3) and SO(5) invariant directions. It turns out that the former is a stable, and the latter an unstable non-supersymmetric type IIB background.
K-mappings and Regression trees

We describe a method for learning a piecewise affine approximation to a mapping f : ℝ<sup>d</sup> → R<sup>p</sup> given a labeled training set of examples {x<sub>1</sub>,. , x<sub>n</sub>} = X ⊂ ℝ<sup>d</sup> and targets {y<sub>1</sub> = f(x<sub>1</sub>), . , y<sub>n</sub> = f(x<sub>n</sub>)} = Y ⊂ ℝ<sup>p</sup>. The method first trains a binary subdivision tree that splits across hyperplanes in X corresponding to high variance directions in Y. A fixed number K of affine regressors of rank q are then trained via a K-means like iterative algorithm, where each leaf must vote on its best fit mapping, and each mapping is updated as the best fit for the collection of leaves that chose it.
Normalized characteristics of AC processing pickups

Recently, an AC processing pickup has been proposed and used in range of applications from stage lighting to EV charging. This new pickup has the advantage of producing high efficiency AC output while retaining a simple circuit topology. However, the exactly analysis of these pickups has been rather difficult and time domain solutions in the form of transcendental equations are required to numerically solve for the steady state operation. This paper produces a set of normalized tables for all the dependent variable for this type of pickup, hence aiding engineers in the design process.
Role of αv Integrins in Adenovirus Cell Entry and Gene Delivery

SUMMARY Adenoviruses (Ad) are a significant cause of acute infections in humans; however, replication-defective forms of this virus are currently under investigation for human gene therapy. Approximately 20 to 25% of all the gene therapy trials (phases I to III) conducted over the past 10 years involve the use of Ad gene delivery for treatment inherited or acquired diseases. At present, the most promising applications involve the use of Ad vectors to irradicate certain nonmetastatic tumors and to promote angiogenesis in order to alleviate cardiovascular disease. While specific problems of using Ad vectors remain to be overcome (as is true for almost all viral and nonviral delivery methods), a distinct advantage of Ad is the extensive knowledge of its macromolecular structure, genome organization, sequence, and mode of replication. Moreover, significant information has also been acquired on the interaction of Ad particles with distinct host cell receptors, events which strongly affect virus tropism. This review provides an overview of the structure and function of Ad attachment (coxsackievirus and Ad receptor [CAR]) and internalization (αv integrins) receptors and discusses their precise role in virus infection and gene delivery. Recent structure studies of integrin-Ad complexes by cryoelectron microscopy are also highlighted. Finally, unanswered questions arising from the current state of knowledge of Ad-receptor interactions are presented in the context of improving Ad vectors for future human gene therapy applications.
Graph-Based Metrics for Insider Attack Detection in VANET Multihop Data Dissemination Protocols

Vehicular networks (VANETs) are a growing research area with a large number of use cases. Foreseen applications include safety applications, traffic efficiency enhancements, and infotainment services. To make future deployment successful, it is imperative that all applications are matched with proper security mechanisms. Current proposals mostly focus on entity authorization by establishing a public key infrastructure. Such proactive security efficiently excludes nonauthorized entities from the network. However, in the face of insider attackers possessing valid key material, we need to consider data-centric methods to complement entity-centric trust. A promising approach for consistency checks, particularly in multihop scenarios, is to exploit redundant information dissemination. If information is received from both honest and malicious vehicles, chances are that attacks can be detected. In this paper, we propose three graph-based metrics to gauge the redundancy of dissemination protocols. We apply our metrics to a baseline protocol, a geocast protocol, and an aggregation protocol using extensive simulations. In addition, we point out open issues and applications of the metrics, such as colluding attackers and eviction of attacker nodes based on detected attacks. Results show that Advanced Adaptive Geocast behaves almost optimally from a routing efficiency point of view but fails to offer sufficient redundancy for data consistency mechanisms in many scenarios. The simulated aggregation protocol shows sufficient redundancy to facilitate data consistency checking.
Dual-Fed Hollow Dielectric Antenna for Dual-Frequency Operation With Large Frequency Ratio

A new dual-fed dual-frequency antenna that integrates a microwave hollow dielectric resonator antenna (DRA) with a high-gain millimeter-wave dielectric Fabry–Perot resonator antenna (FPRA) is investigated. To obtain the dual-frequency operation, the dielectric and air regions of the hollow DRA are designed to satisfy the resonance condition of the FPRA. The DRA and FPRA are excited by a strip and a WR-34 waveguide, respectively. For demonstration, a prototype that covers both 2.4- and 24-GHz ISM bands was fabricated and tested. The S-parameters, radiation pattern, antenna gain, and antenna efficiency are studied, and reasonable agreement between the measured and simulated results is found.
Improper Signaling for Virtual Full-Duplex Relay Systems

Virtual full-duplex (VFD) is a powerful solution to compensate the rate loss of half-duplex relaying without the need to full-duplex capable nodes. Inter-relay interference (IRI) challenges the operation of VFD relaying systems. Recently, improper signaling is employed at both relays of the VFD to mitigate the IRI by imposing the same signal characteristics for both relays. To further boost the achievable rate performance, asymmetric time sharing VFD relaying system is adopted with different improper signals at the half-duplex relays. The joint tuning of the three design parameters improves the achievable rate performance at different ranges of IRI and different relays locations. Extensive simulation results are presented and analyzed to show the achievable rate gain of the proposed system and understand the system behavior.
Face Detection in Color Images Using AdaBoost Algorithm Based on Skin Color Information

This paper proposes a novel technique for detecting faces in color images using AdaBoost algorithm combined with skin color segmentation. First,skin color model in the YCbCr chrominance space is built to segment the non-skin-color pixels from the image. Then, mathematical morphological operators are used to remove noisy regions and fill holes in the skin-color region, so we can extract candidate human face regions. Finally, these face candidates are scanned by cascade classifier based on AdaBoost for more accurate face detection. This system detects human face in different scales, various poses, different expressions, lighting conditions, and orientation. Experimental results show the proposed system obtains competitive results and improves detection performance substantially.
Solving minimal realisation problem of positive two-dimensional hybrid systems in the form of second Fornasini-Marchesini model

In this paper, the new alternative method for the determination of the set of all minimal realisations of the positive two-dimensional hybrid linear systems in a second Fornasini-Marchesini (IIF-M) model based on the two-dimensional digraphs theory has been presented. In addition, all realisations in the set are minimal. For the proposed method, parallel computing algorithm was constructed. Algorithm is based on GPGPU (General-Purpose Computing on Graphics Processing Units) computing method to gain needed speed and computational power for a such solution. Proposed method is discussed and illustrated with numerical examples.
Nuclear Uptake and Dosimetry of 64Cu-Labeled Chelator–Somatostatin Conjugates in an SSTr2-Transfected Human Tumor Cell Line

64Cu radiopharmaceuticals have shown tumor growth inhibition in tumor-bearing animal models with a relatively low radiation dose that may be related to nuclear localization of the 64Cu in tumor cells. Here we address whether the nuclear localization of 64Cu from a 64Cu-labeled chelator–somatostatin conjugate is related to the dissociation of the radio-copper from its chelator. The 64Cu complex of 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid (TETA) has demonstrated instability in vivo, whereas 64Cu-CB-TE2A (CB-TE2A is 4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6. 2]hexadecane) was highly stable. Methods: Receptor binding, nuclear uptake, internalization, and efflux assays were performed to characterize the interaction with the somatostatin receptor and the intracellular fate of 64Cu-labeled chelator–peptide conjugates in A427-7 cells. From these data, the absorbed dose to cells was calculated. Results: 64Cu-TETA-Y3-TATE (64Cu-[1]) and 64Cu-CB-TE2A-Y3-TATE (64Cu-[2]) had high affinity for somatostatin receptor subtype 2 (SSTr2) in A427-7 cells. After 3 h, 64Cu-[2] showed greater internalization (>30%) compared with 64Cu-[1] (∼15%). There was uptake of 64Cu-[1] in nuclei of 427–7 cells (9.4% ± 1.7% at 24 h), whereas 64Cu-[2] showed minimal nuclear accumulation out to 24 h (1.3% ± 0.1%). A427-7 cells were exposed to 0.40 Gy from 64Cu-[1] and exposed to 1.06 Gy from 64Cu-[2]. External beam irradiation of A427-7 cells showed <20% cell killing at 1 Gy. Conclusion: These results are consistent with our hypothesis that dissociation of 64Cu from TETA leads to nuclear localization. Dosimetry calculations indicated that the nuclear localization of 64Cu-[1] was not significant enough to increase the absorbed dose to the nuclei of A427-7 cells. These studies show that 64Cu localization to cell nuclei from internalizing, receptor-targeted radiopharmaceuticals is related to chelate stability.