Miracle-dz/UniFAR-FTUs huggingface dataset:
Recent Studies in the Design of a Self-paced Brain Interface with Low False Positive Rate

The findings of two recent studies that aim at developing a self-paced brain interface (BI) system with low false positive rates are discussed. The first study examines the use of information extracted from different neurological phenomena and the second study examines the wavelet coefficients extracted from a single neurological phenomenon. The analysis of the data of two subjects shows that both are successful at yielding low false positive rates. These studies also show that for each subject, a unique set of features and EEG channels lead to superior performance
Automatic extraction of numerical values from unstructured data in EHRs

Clinical data recorded in modern EHRs are very rich, although their secondary use research and medical decision may be complicated (eg, missing and incorrect data, data spread over several clinical databases, information available only within unstructured narrative documents). We propose to address the issue related to the processing of narrative documents in order to detect and extract numerical values and to associate them with the corresponding concepts (or themes) and units. We propose to use a CRF supervised categorisation for the detection of segments (themes, numerical sequences and units) and a rules-based system for the association of these segments among them in order to build semantically meaningful sequences. The average results obtained are competitive (0.96 precision, 0.78 recall, and 0.86 F-measure) and we plan to use the system with larger clinical data.
Smile! Social Reward Drives Attention

Human social behavior is fine-tuned by interactions between individuals and their environments. Here we show that social motivation plays an important role in this process. Using a novel manipulation of social reward that included elements of real-life social exchanges, we demonstrate the emergence of attentional orienting for coincidental spatial associations that received positive social reward. After an interaction with the experimenter, participants completed a computerized task in which they received positive, negative, or no social reward for their performance to spatially congruent, spatially incongruent, and neutral cue–target pairings, respectively. Even though cue–target spatial correspondences remained at chance, attentional benefits emerged and persisted a day later for targets that received positive social reward. Our data further revealed that participants’ level of social competence, as measured by the Autism-Spectrum Quotient scale, was predictably related to the magnitude of their reward-driven attentional benefits. No attentional effects emerged when the social interaction and social reward manipulations were removed. These results show that motivational incentives available during social exchanges affect later individual cognitive functioning, providing one of the first insights into why seemingly ambiguous social signals produce reliable and persistent attentional effects.
Expression of Nerve Growth Factor and Its Receptors NTRK1 and TNFRSF1B Is Regulated by Estrogen and Progesterone in the Uteri of Golden Hamsters1

Abstract Experiments were conducted using female golden hamsters to identify the presence of nerve growth factor (NGF) and its receptors NTRK1 and TNFRSF1B in the uteri of female animals and regulation on their expression by estrogen and progesterone. NGF and its receptor NTRK1 were immunolocalized to luminal epithelial cells, glandular cells, and stromal cells. TNFRSF1B was immunolocalized in luminal epithelial and glandular cells, with no staining found in stromal cells of the uterine horns of normal cyclic golden hamsters. Strong immunostaining of NGF and its receptors NTRK1 and TNFRSF1B was observed in uteri on the day of proestrus as compared to the other stages of the estrous cycle. Results of immunoblot analysis of NGF revealed that there was a positive correlation between uterine NGF expression and plasma concentrations of estradiol-17β. To clarify the effects of estrogen and progesterone on NGF, NTRK1, and TNFRSF1B expression, adult female golden hamsters were ovariectomized and treated with estradiol-17β and/or progesterone. Immunoblot analysis and immunohistochemistry indicated that estradiol-17β stimulated expression of NGF and its two receptors in the uterus. Treatment with progesterone also increased NGF and NTRK1 expression in the uterus. However, no additive effect of these steroids on expression of NGF and its receptors was observed. Changes in uterine weights induced by estradiol-17β and/or progesterone showed the same profile with that of NGF, suggesting that a proliferative act of NGF may be involved in uterine growth. These results suggest that NGF may play important roles in action of steroids on uterine function.
Depression, pain intensity, and interference in acute spinal cord injury.

BACKGROUND The high prevalence of pain and depression in persons with spinal cord injury (SCI) is well known. However the link between pain intensity, interference, and depression, particularly in the acute period of injury, has not received sufficient attention in the literature. OBJECTIVE To investigate the relationship of depression, pain intensity, and pain interference in individuals undergoing acute inpatient rehabilitation for traumatic SCI. METHODS Participants completed a survey that included measures of depression (PHQ-9), pain intensity ("right now"), and pain interference (Brief Pain Inventory: general activity, mood, mobility, relations with others, sleep, and enjoyment of life). Demographic and injury characteristics and information about current use of antidepressants and pre-injury binge drinking also were collected. Hierarchical multiple regression was used to test depression models in 3 steps: (1) age, gender, days since injury, injury level, antidepressant use, and pre-injury binge drinking (controlling variables); (2) pain intensity; and (3) pain interference (each tested separately). RESULTS With one exception, pain interference was the only statistically significant independent variable in each of the final models. Although pain intensity accounted for only 0.2% to 1.2% of the depression variance, pain interference accounted for 13% to 26% of the variance in depression. CONCLUSION Our results suggest that pain intensity alone is insufficient for understanding the relationship of pain and depression in acute SCI. Instead, the ways in which pain interferes with daily life appear to have a much greater bearing on depression than pain intensity alone in the acute setting.
The Effects of Different Level Cluster Tip Reduction and Foliar Boric Acid Applications on Yield and Yield Components of Italia Grape Cultivar

This study was carried out on Italia grape variety (Vitis vinifera L.) in Konya province, Turkey in 2016. The cultivar is five years old and grown on 1103 Paulsen rootstock. It was determined the effects of applications of the Control (C), 1/3 Cluster Tip Reduction (1/3 CTR), 1/6 Cluster Tip Reduction (1/6 CTR), 1/9 Cluster Tip Reduction (1/9 CTR), 1/3 CTR+Boric Acid (BA), 1/6 CTR+BA, 1/9 CTR+BA, on yield and yield components of the Italia grape variety. The results were obtained as the highest fresh grape yield (4.74 g) with 1/9 CTR+BA application; the highest cluster weight (220.08 g) with 1/3 CTR application; the highest 100 berry weight (565.85 g) with 1/9 CTR+BA application; as the highest maturity index (49.28) with 1/9 CTR+BA application; as the highest must yield (685.33 ml/kg) with 1/3 CTR+BA and (685.33 ml/kg) with 1/9 CTR+BA applications. To increase the fresh grape yield, 100 berry weight and maturity index in the Italia grape variety, the 1/9 CTR+BA application can be recommended. Keywords—Italia grape variety, boric acid, cluster tip reduction, yield, yield components.
Logic Picture-Based Dynamic Power Estimation for Unit Gate-Delay Model CMOS Circuits

In this research, a fast methodology to calculate the exact value of the average dynamic power consumption for CMOS combinational logic circuits is developed. The delay model used is the unit-delay model where all gates have the same propagation delay. The main advantages of this method over other techniques are its accuracy, as it is deterministic and it requires less computational effort compared to exhaustive simulation approaches. The methodology uses the Logic Pictures concept for obtaining the nodes’ toggle rates. The proposed method is applied to well-known circuits and the results are compared to exhaustive simulation and Monte Carlosimulation methods.
Pmr1, a Golgi Ca2+/Mn2+-ATPase, is a regulator of the target of rapamycin (TOR) signaling pathway in yeast

The rapamycin·FKBP12 complex inhibits target of rapamycin (TOR) kinase in TORC1. We screened the yeast nonessential gene deletion collection to identify mutants that conferred rapamycin resistance, and we identified PMR1, encoding the Golgi Ca2+/Mn2+-ATPase. Deleting PMR1 in two genetic backgrounds confers rapamycin resistance. Epistasis analyses show that Pmr1 functions upstream from Npr1 and Gln-3 in opposition to Lst8, a regulator of TOR. Npr1 kinase is largely cytoplasmic, and a portion localizes to the Golgi where amino acid permeases are modified and sorted. Nuclear translocation of Gln-3 and Gln-3 reporter activity in pmr1 cells are impaired, but expression of functional Gap1 in the plasma membrane of a pmr1 strain in response to nitrogen limitation is enhanced. These two phenotypes suggest up-regulation of Npr1 function in the absence of Pmr1. Together, our results establish that Pmr1-dependent Ca2+ and/or Mn2+ ion homeostasis is necessary for TOR signaling.
Efecto del yoduro de potasio sobre la respuesta inmune en la esporotricosis

El yoduro de potasio (KI), tratamiento de eleccion para la esporotricosis, aparentemente no tiene una accion directa sobre el Sporothrix schenckii. Las curaciones espontaneas y la variabilidad de la presentacion clinica han fortalecido la idea de que el KI interacciona con la respuesta inmune del huesped. En los individuos con esporotricosis, el proceso fagocitico es ineficiente y se ha observado que los mecanismos microbicidas de halogenacion fallan para controlar la enfermedad. Existen evidencias de que el bloqueo de los radicales libres disminuye con la participacion del KI. Se desconoce como actuan en la esporotricosis la inmunidad humoral y celular, por lo que queda por determinar si en esta micosis existe una influencia del KI a traves de otros procesos o factores de la respuesta inmune.
Identification of tyrosine sulfation in Conus pennaceus conotoxins α‐PnIA and α‐PnIB: further investigation of labile sulfo‐ and phosphopeptides by electrospray, matrix‐assisted laser desorption/ionization (MALDI) and atmospheric pressure MALDI mass spectrometry

Liquid chromatography/electrospray ionization mass spectrometry was used to investigate the peptide composition of the venom of Conus pennaceus, a molluscivorous cone shell from the Red Sea. Based on observed Mrs, this venom contained all known conotoxins previously isolated and identified from this species. Interestingly, the doubly protonated species of only two of these conotoxins, α-PnIA and α-PnIB, showed additional related ions at +40 m/z (+80 Da), indicating the presence of either sulfation or phosphorylation in both components. High-performance liquid chromatographic (HPLC) fractions containing these two conotoxins were examined by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry in both positive and negative ion modes, as well as by MALDI high-energy collision-induced dissociation. These experiments established the presence of a single sulfated tyrosine residue within both α-PnIA and α-PnIB. Hence their post-translationally modified sequences are GCCSLPPCAANNPDY(S)C-NH2 (α-PnIA) and GCCSLPPCALSNPDY(S)C-NH2 (α-PnIB). This assignment was supported by comparison of their mass spectral behavior with that of known sulfated and phosphorylated peptides. This data clarified further the distinguishing features of the ionization and fragmentation of such modified peptides. Selective disulfide folding of synthetic α-PnIB demonstrated that both sulfated and non-sulfated toxins co-elute on reversed-phase HPLC and that α-PnIB possesses the same disulfide connectivity as other ‘classical’ α-conotoxins reported previously. Copyright © 1999 John Wiley & Sons, Ltd.
Unified Maximum Likelihood Estimates for Closed Capture–Recapture Models Using Mixtures

Summary. Agresti (1994, Biometrics50, 494–500) and Norris and Pollock (1996a, Biometrics52, 639–649) suggested using methods of finite mixtures to partition the animals in a closed capture‐recapture experiment into two or more groups with relatively homogeneous capture probabilities. This enabled them to fit the models Mh, Mbh (Norris and Pollock), and Mth (Agresti) of Otis et al. (1978, Wildlife Monographs62, 1–135). In this article, finite mixture partitions of animals and/or samples are used to give a unified linear‐logistic framework for fitting all eight models of Otis et al. by maximum likelihood. Likelihood ratio tests are available for model comparisons. For many data sets, a simple dichotomy of animals is enough to substantially correct for heterogeneity‐induced bias in the estimation of population size, although there is the option of fitting more than two groups if the data warrant it.
The relationship between national identity, subjective well-being and meaning in life

Studies have shown a strong relationship between national identity and some of the constructs of positive psychology. So far, these topics have rarely been researched in the Macedonian context. The purpose of this study was to examine the relationship between national identity, subjective well-being and meaning in life. Thus, 204 undergraduate students participated in the study, 146 female and 58 male students at the age of 18 to 23 years. The data was acquired with the following four scales: national identity was measured with The National Identity Scale (NIS); the meaning in life was measured with the Meaning in Life Questionnaire (MIQ); the cognitive aspect of subjective well-being was measured with the Satisfaction With Life Scale (SWLS); and the affective aspect was measured with the Positive and Negative Affect Schedule (PANAS). It has been hypothesized that the students with higher national identity would have higher satisfaction with life, more positive affects and higher meaning in life; contrary to the students with lower national identity who would have lower satisfaction with life, more negative affects and lower meaning in life. The relationships between each dimension were estimated with the Pearson Product Moment Correlation Coefficient, and the results partially confirmed the predictions. Positive significant correlation was found between national identity, satisfaction with life and the presence of meaning in life. No significant relationship was found between national identity and the affective (positive and negative) aspects of subjective well-being. These findings are important because they provide a new insight into the relationship between the construct of national identity and the constructs of positive psychology, meaning in life and the aspects of subjective well-being.
Semi-Supervised Feature Selection with Universum Based on Linked Social Media Data

Independent and identically distributed (i.i.d) assumptions are commonly used in the machine learning community. However, social media data violate this assumption due to the linkages. Meanwhile, with the variety of data, there exist many samples, i.e., Universum, that do not belong to either class of interest. These characteristics pose great challenges to dealing with social media data. In this letter, we fully take advantage of Universum samples to enable the model to be more discriminative. In addition, the linkages are also taken into consideration in the means of social dimensions. To this end, we propose the algorithm Semi-Supervised Linked samples Feature Selection with Universum (U-SSLFS) to integrate the linking information and Universum simultaneously to select robust features. The empirical study shows that U-SSLFS outperforms state-of-theart algorithms on the Flickr and BlogCatalog. key words: universum, feature selection, social media, semi-supervised learning
Abordagem centrada na pessoa : um estudo sobre as implicações dos trabalhos com grupos intensivos para a terapia centrada no cliente

Este estudo baseia-se nos principios teoricos da Abordagem Centrada na Pessoa - denominacao generica adotada pelo psicologo americano Carl R. Rogers e colaboradores para englobar atividades desenvolvidas em diversos campos. Historicamente, esta abordagem teve origem no Aconselhamento e na Psicoterapia, passando a incluir, posteriormente, o Ensino Centrado no Aluno, os Grupos de Encontro, os Workshops de Grandes Grupos Intensivos, e os Encontros de Comunidade. O objetivo da pesquisa consiste em analisar esta evolucao, de forma a caracterizar a influencia das experiencias com Grandes Grupos Intensivos na pratica da Terapia Centrada no Cliente. A enfase recai sobre a necessidade de um desenvolvimento teorico consistente e que respeite os aspectos presentes na pratica atual, conferindo-lhe legitimidade como uma abordagem psicossocial aos problemas humanos. Esta nao e apenas uma pesquisa bibliografica, pois inclui uma revisao teorica, levada a efeito atraves de uma leitura reflexiva da literatura existente, a partir da qual descrevem-se as tendencias do campo analisado, sob a perspectiva do metodo psicoterapeutico. O estudo compoe-se de duas partes: Parte I - descreve as fases percorridas pela Terapia Centrada no Cliente, ao longo de sua evolucao, atraves da compilacao de dados historicos e caracteriza as varias formas de trabalhos com Grupos na Abordagem Centrada na Pessoa. de forma a incluir a Psicoterapia de Grupo. os Grupos de Encontro e os Encontros de Comunidade; Parte II - contem uma analise de fatores descritos nos trabalhos com Grupos Intensivos com implicacoes para a psicoterapia individual; descreve as limitacoes das formulacoes teoricas da Terapia Centrada no Cliente e apresenta uma proposta no sentido de supera-las. de forma a possibilitar uma nova configuracao a qual denomina-se Psicoterapia Centrada na Pessoa; o ultimo Capitulo. discorre sobre possiveis aplicacoes desta abordagem ao campo da Saude Mental Publica no Brasil Abstract
Involvement of Gas7 in nerve growth factor‐independent and dependent cell processes in PC12 cells

Gas7, a growth arrest‐specific gene originally isolated from serum‐starved mouse fibroblast cells, is expressed in vivo predominantly in the brain and is required for neurite formation in cultured mouse cerebellar neurons (Ju et al. [ 1998 ] Proc. Natl. Acad. Sci. USA 95: 11423–11428). Here we report that Gas7 plays a key role in the morphological differentiation of PC12 preneuronal rat pheochromocytoma cells (PC12 cells). We found that overexpression of murine Gas7 in PC12 cells leads to an expanded cell morphology and promotes spike‐like cell processes that resemble the early stages of neurite formation. These processes undergo elongation upon addition of nerve growth factor (NGF). We also found that the addition of NGF induces the production of endogenous rat‐Gas7 (rGas7), which is transiently elevated prior to the appearance of NGF‐promoted neurite outgrowths. Furthermore, inhibition of endogenous rGas7 production by antisense nucleotides complimentary to the translation initiation region of a rGas7 cDNA (AJ131902) reduces the NGF‐promoted neurite outgrowths. Our results demonstrate that Gas7 by itself influences early cell morphological development and likely functions as an early‐stage intermediary in NGF‐induced neuronal differentiation of PC12 culture cells. © 2003 Wiley‐Liss, Inc.
Vive la différence!* What morphology is about

What is morphology? What is part of it and what is not? Our contention is that these two questions are really one and the same. While it is true that the discovery procedures designed in the 40's and 50's to identify morphemes were fairly disconnected from theory, it seems only fair that a definition of morphology should be somewhat helpful in determining where it begins and where it ends. Whereas most linguists seem to believe that morphology is about similarities and 'recurring partials', we shall explore the idea, aphoristically advanced in Ford & Singh (1991), Ford, Singh, and Martohardjono (1997), and Singh & Dasgupta (1999), that it is actually about systematic exploitation of difference or contrast in l-lexica. In other words, we intend to show that a proper focus on difference (rather than on similarity) can help morphology get rid of problems it seems to have created for itself by going after the identification and segmentation of 'similar partials'.
Activated dynamics, loss of ergodicity, and transport in supercooled liquids.

The dynamics of the transition from supercooled liquid to glass is examined in terms of several probes: ergodic measures, self-diffusion coefficients, the Van Hove self-correlation functions, and the shear viscosity. Constant-pressure molecular-dynamics calculations at several temperatures are performed for a Lennard-Jones mixture and binary mixtures of soft spheres. The temperature dependence of the ergodicity diffusion parameters for both systems follow the Vogel-Fulcher law. On the other hand, the self-diffusion coefficients exhibit Arrhenius behavior for the soft-sphere system, but Vogel-Fulcher behavior for the Lennard-Jones system. These observations suggest that loss of effective ergodicity may be the universal feature of glass-forming substances. Various probes of the dynamics of the mixtures studied here suggest that the mechanism for mass transport dramatically changes from a simple diffusive process to one that involves activated transitions. The temperature at which this occurs is higher than the glass transition temperature ${\mathit{T}}_{\mathit{g}}$ and lies in the range 1.1T/${\mathit{T}}_{\mathit{g}}$1.3. In this temperature range the effective ergodic times also increase very rapidly and suggest that the relaxation process is dominated by the presence of barriers in configuration space. We also show that the Stokes-Einstein relation between the shear viscosity and the self-diffusion coefficients starts to break down in the temperature range where the ergodic convergence times increase dramatically.
Correction Old fossils – young species : evolutionary history of an endemic gastropod assemblage in Lake Malawi

Received Accepted Tribal war occurs when a coalition of individuals use force to seize reproduction-enhancing resources, and it may have affected human evolution. Here, we develop a population-genetic model for the coevolution of costly male belligerence and bravery when war occurs between groups of individuals in a spatially subdivided population. Belligerence is assumed to increase an actor’s group probability of trying to conquer another group. An actor’s bravery is assumed to increase his group’s ability to conquer an attacked group. We show that the selective pressure on these two traits can be substantial even in groups of large size, and that they may be driven by two independent reproduction-enhancing resources: additional mates for males and additional territory (or material resources) for females. This has consequences for our understanding of the evolution of intertribal interactions, as hunter-gatherer societies are well known to have frequently raided neighbouring groups from whom they appropriated territory, goods and women.