Miracle-dz/UniFAR-FTUs huggingface dataset:
The fit between business model innovation and demand-side dynamics: catch-up of China’s latecomer mobile handset manufacturers

Abstract This paper aims to answer an important question: whether and how, in emerging markets, latecomer firms with limited technological endowments can catch up with industry incumbents that dominate the technological and market frontiers. Adopting the perspective of demand-side dynamics and analyzing the case of China’s mobile handset manufacturing industry between 1998 and 2008, the paper finds that in emerging markets, latecomer firms with limited technological innovation capability are able to achieve market share catch-up by using effectiveness-centered business model innovation. Specifically, business model innovations that provided the most effective (though not necessarily the most efficient or novel) solutions to cater to changing customer preferences were the winners in helping latecomers achieve catch-up.
SPECT/CT Lymphoscintigraphy of Heterotopic Cardiac Grafts Reveals Novel Sites of Lymphatic Drainage and T Cell Priming

The normal function of lymphatic vessels is to facilitate the trafficking of antigen presenting cells to draining lymph nodes where they evoke an immune response. Donor lymphatic vessels are not connected to that of recipients’ during organ transplantation. The pathophysiology of this disruption has received little attention. Murine heterotopic cardiac transplantation has been used extensively in transplantation research. Following vascularized organ transplantation, the main site of allosensitization is thought to be in the spleen of the recipient as a result of migration of donor passenger leukocytes via blood. Here, using Single Photon Emission Computed Tomography/Computerized Tomography (SPECT/CT) lymphoscintigraphy, we studied the pattern of lymphatic flow from mouse heterotopic abdominal cardiac grafts and identified mediastinal lymph nodes as the draining nodes for the donor graft. Staining with HY tetramer after transplantation of HY mismatched heart grafts and ELISPOT following allogeneic grafts to detect donor specific T cells revealed them as important sites for allosensitization. Our data indicates that mediastinal lymph nodes play a crucial role in the alloimmune response in this model, and should be used for ex vivo and adoptive transfer studies after transplantation in addition to the spleen.
Individual and parallel behavior of high current density, high-voltage 4h-silicon carbide PiN diodes

The preferred method of switching the very high currents and voltages present in electromagnetic launch systems is to use arrays of solid-state devices. The effort to reduce the overall switch mass and volume has generated interest in advanced high-power, high-temperature semiconductor materials such as silicon carbide (SiC). Devices produced from SiC are expected to provide significant performance improvements in very high-power switching devices over current devices based on silicon (Si) materials. The performance improvement expectations are based on SiC's superior material properties, most notably for power devices are a band gap of 3.26 eV (three times that of Si), a breakdown field of 2-4 MV cm/sup -1/ (order of magnitude better than Si), a thermal conductivity of 4.5 W cm/sup -1/ K/sup -1/ (three times that of Si), and a saturated drift velocity of 2/spl times/10/sup 7/ cm s/sup -1/ (two times that of Si). This paper describes the results of recent experiments at the Institute for Advanced Technology at The University of Texas at Austin in which SiC PiN diodes arranged in parallel pairs are subjected to high current density pulses. The failure modes of paralleled devices are compared to the failure modes seen in individual devices subjected to high current density pulses (maximum of 2.34/spl times/10/sup 4/ A cm/sup -2/). The results show current equalization between paralleled high-voltage diodes when subjected to high current densities, which suggests that high-voltage SiC active devices will also function well in parallel arrangements.
La construcción mediática de la migración en el Mediterráneo: ¿no-ciudadanía en la prensa española?

espanolEl objetivo del presente articulo es desvelar el relato de la prensa espanola sobre los migrantes que intentan cruzar la frontera de la Union Europea pero se ven estancados en la misma a causa de la estrecha vigilancia. Para ello, se ha llevado a cabo el analisis de contenido y el analisis critico del discurso de una muestra de noticias de varios periodicos nacionales, de aquellas que informan sobre la migracion irregular en el Mediterraneo. No se han encontrado grandes diferencias en el tratamiento de las noticias publicadas por los periodicos seleccionados. La construccion del discurso sigue la logica de las politicas migratorias de la Union Europea, que consisten en la externalizacion de las fronteras (la gestion de las mismas fuera de la UE) y la produccion estatal y mediatica del estatuto de irregularidad de la migracion. En el discurso mediatico los migrantes son retratados en la mayoria de los casos como agentes pasivos, como victimas de las mafias o como objeto de atencion asistencial por parte de diferentes entidades. En algunas noticias aparecen como actores que hacen uso de la violencia para alcanzar su proposito, mientras que son pocos los casos en los que aparecen como sujeto activo no asociado a conflictos. En suma, el relato dominante “desciudadaniza” a estas personas en los distintos discursos analizados. EnglishThe main purpose of the present article is to uncover the account of the Spanish press about migrants who try to cross the European Union border but find themselves at a standstill caused by the strong surveillance. In order to that, we use both content analysis and critical discourse analysis of a news sample of several national newspapers, specifically of those news which inform about irregular migration in the Mediterranean Sea. We haven’t found huge differences in the news treatment offered by selected newspapers. The way that the discourse concerning migration is elaborated follows the logic of European migration policy, which is based on the externalization of borders (the management of EU borders abroad) and the state and media production of the statute of irregularity of migrants. According to the discourse of the media, migrants are reflected in most cases as passive agents, mafia victims or assisted by different entities. Sometimes they appear as actors using violence to reach their purpose while the image of them as an active subject which is not linked to conflicts is limited. To sum up, the prevailing discourse “takes citizenship away” from these people, as we have seen in the analyses of the different media outlets.
Creative Collaboration General Examination Administered by Mitch Resnick

The rapid diffusion of systems such as email and discussions boards, instant messaging, wikis, and social media, has facilitated collaboration among previously unprecedentedly large groups. For example, English Wikipedia integrates the work of hundreds of thousands of contributors each month and today represents the aggregate product of millions of individuals’ work (Ortega, 2009). Facebook now involves more than a billion users engaged in collaborative information gathering and distribution, sensemaking (Weick, 1995), and social interaction. Making sense of this phenomena is difficult enough. The challenges to supporting and reproducing the most successful of these examples are overwhelming.
Intracoronary streptokinase after primary percutaneous coronary intervention.

BACKGROUND Microvascular perfusion is often impaired after primary percutaneous coronary intervention (PCI). We proposed that in situ thrombosis might contribute to poor myocardial perfusion in this setting. To test this hypothesis, we evaluated the effect of low-dose intracoronary streptokinase administered immediately after primary PCI. METHODS Forty-one patients undergoing primary PCI were randomly assigned to receive intracoronary streptokinase (250 kU) or no additional therapy. Two days later, cardiac catheterization was repeated, and coronary hemodynamic end points were measured with the use of a guidewire tipped with pressure and temperature sensors. In patients with anterior myocardial infarction, the deceleration time of coronary diastolic flow was measured with transthoracic echocardiography. At 6 months, angiography, echocardiography, and technetium-99m single-photon-emission computed tomography were performed. RESULTS Two days after PCI, all measures of microvascular function (means +/-SD) were significantly better in the streptokinase group than in the control group, including coronary flow reserve (2.01+/-0.57 vs. 1.39+/-0.31), the index of microvascular resistance (16.29+/-5.06 U vs. 32.49+/-11.04 U), the collateral-flow index (0.08+/-0.05 vs. 0.17+/-0.07), mean coronary wedge pressure (10.81+/-5.46 mm Hg vs. 17.20+/-7.93 mm Hg), systolic coronary wedge pressure (18.24+/-6.07 mm Hg vs. 33.80+/-11.00 mm Hg), and diastolic deceleration time (828+/-258 msec vs. 360+/-292 msec). The administration of intracoronary streptokinase was also associated with a significantly lower corrected Thrombolysis in Myocardial Infarction frame count (the number of cine frames required for dye to travel from the ostium of a coronary artery to a standardized distal coronary landmark) at 2 days. At 6 months, however, there was no evidence of a difference between the two study groups in left ventricular size or function. CONCLUSIONS In our pilot trial, the administration of low-dose intracoronary streptokinase immediately after primary PCI improved myocardial reperfusion but not long-term left ventricular size or function. These findings require clarification in a larger trial. (ClinicalTrials.gov number, NCT00302419.)
MicroRNA-Regulated Network Motifs with Drug Association in Lung Cancer

The value of microRNAs as therapeutic targets is now widely recognized. The regulation of microRNAs has an important role in cancer progression, and increasing importance of microRNA is the use of microRNA signatures in the diagnosis, prognosis and also drug treatment of many kinds of cancer such as lung cancer, breast cancer, and colon cancer. This study aim to understand the role of microRNA associated in cancer therapies and drug discovery, we identified microRNAs and their down-stream protein-protein interaction motifs for lung cancer based on a network topology analysis approach which is Clique Percolation Clustering Method (CPM). Then, target drugs of each significant motif were investigated by drug-gene interaction databases. It is expected that this study may insight explore the role of microRNA in cancer therapy and associated with drug response.
Germinal epithelium, folliculogenesis, and postovulatory follicles in ovaries of rainbow trout, Oncorhynchus mykiss (Walbaum, 1792) (Teleostei, protacanthopterygii, salmoniformes)

The rainbow trout, Oncorhynchus mykiss (Walbaum, 1792), is a salmoniform fish that spawns once per year. Ripe females that had ovulated naturally, and those induced to ovulate using salmon gonadotropin‐releasing hormone, were studied to determine whether follicles were forming at the time of spawning and to describe the process of folliculogenesis. After ovulation, the ovaries of postspawned rainbow trout were examined histologically, using the periodic acid‐Schiff procedure, to stain basement membranes that subtend the germinal epithelium and to interpret and define the activity of the germinal epithelium. After spawning, the ovary contained a few ripe oocytes that did not ovulate, numerous primary growth oocytes including oocytes with cortical alveoli, and postovulatory follicles. The germinal epithelium was active in postspawned rainbow trout, as determined by the presence of numerous cell nests, composed of oogonia, mitotic oogonia, early diplotene oocytes, and prefollicle cells. Cell nests were separated from the stroma by a basement membrane continuous with that subtending the germinal epithelium. Furthermore, follicles containing primary growth oocytes were connected to the germinal epithelium; the basement membrane surrounding the follicle joined that of the germinal epithelium. After ovulation, the basement membrane of the postovulatory follicle was continuous with that of the germinal epithelium. We observed consistent separation of the follicle, composed of an oocyte and surrounding follicle cells, from the ovarian stroma by a basement membrane. The follicle is derived from the germinal epithelium. As with the germinal epithelium, follicle cells derived from it never contact those of the connective tissue stroma. As with epithelia, they are always separated from connective tissue by a basement membrane. J. Morphol. , 2007. © 2007 Wiley‐Liss, Inc.
A second global regulator gene (arcB) mediating repression of enzymes in aerobic pathways of Escherichia coli

In Escherichia coli anaerobic growth lowers the basal or induced levels of numerous enzymes associated with aerobic metabolism. Mutations in arcA (dye) at min 0 relieve this pleiotropic anaerobic repression and render the cell sensitive to the redox dye toluidine blue. In this study we identified a second pleiotropic control gene, arcB, at min 69.5. Mutations, including a deletion, in this gene also relieved the anaerobic repression and caused sensitivity to toluidine blue. Mutations in arcA or arcB did not significantly change the catabolite repression of the target phi(sdh-lacZ) operon, in which lacZ is fused to a structural gene for succinate dehydrogenase, nor did the mutations strikingly influence the pattern of excretion products during glucose fermentation. The presence of arcA+ in a multicopy plasmid restored anaerobic repression in arcB mutants, as indicated by the expression of phi(sdh-lacZ). The arcB product might be a sensor protein for the redox or energy state of the arc regulatory system.
Lipid Transfer Proteins and Allergy to Oranges

Background: Lipid transfer proteins (LTPs) are relevant fruit allergens, recently proposed as model plant food allergens. No citrus fruit allergen has been characterized to date. We sought to identify and isolate citrus fruit LTPs and to explore their relevance in orange allergy. Methods: Twenty-seven patients, showing mainly oral allergy syndrome after orange ingestion, as well as positive prick responses and serum-specific IgE levels to orange, were selected. Natural orange and lemon LTPs, as well as a recombinant orange LTP isoform expressed in Pichia pastoris, were isolated by chromatographic methods and characterized by N-terminal amino acid sequencing and matrix-assisted laser desorption/ionizaion mass spectrometry, and DNA sequencing of the corresponding cDNA in the case of the recombinant allergen. Specific IgE determination, immunodetection, ELISA-inhibition assays and in vivo skin prick tests (SPTs) were performed with all three purified allergens and with the major peach LTP allergen, Pru p 3. Results: The natural allergens purified from orange (nCit s 3) and lemon (nCit l 3) showed very similar N-terminal amino acid sequences (18 out of 20 identical residues), typical of LTPs, and molecular masses of 9,610 and 9,618 Da, respectively. The recombinant orange isoform (rCit s 3) expressed in P. pastoris (16 out of 20 residues identical to its natural counterpart in the N-terminal region) presented 92 amino acid residues and 9,463 Da, and 67% sequence identity with rPru p 3. Of the 27 sera analyzed, specific IgE to the purified allergens was found in 54% for nCit l 3, 48% for nCit s 3, 46% for rCit s 3 and 37% for rPru p 3. Positive SPT responses were obtained in 7 out of 26 patients tested for nCit s 3, 3 out of 8 for nCit l 3 and 10 out of 26 for nPru p 3. ELISA-inhibition assays showed an equivalent IgE-binding pattern for the natural and recombinant orange LTPs, and IgE cross-reactivity among the purified orange, lemon and peach LTP allergens. Conclusions: Members of the LTP allergen family are involved in allergy to oranges, displaying positive in vitro and in vivo reactions in 30–50% of the patients studied. Both orange and lemon allergens show cross-reactivity with the major peach allergen Pru p 3.
Social Environment Determinants of Life Expectancy in Developing Countries: A Panel Data Analysis

Despite remarkable improvements in health over the past 50 years, there still remain a great number of health challenges around the world. This study examined the relationship between life expectancy rate (as a proxy for health status) with health expenditure, gross domestic product, education index, improved water coverage, and improved sanitation facilities in 108 selected developing countries using annual panel data within the period of 2006–2010. The empirical results from using the panel data approach showed a positive relationship between life expectancy rate and all of those explanatory variables. The relationship between life expectancy with education index and gross domestic product were significant at 1% and 5% significance levels, respectively. Furthermore, the causality finding showed that there is no short-run causality between life expectancy and its determinants. There is a unidirectional causality running from the independent variables of health expenditure, education index, improved water, and improved sanitation to life expectancy at birth. On the other hand, bidirectional causality exists between life expectancy and income in the long-run by employing VECM test. These independent variables can be considered as important determinants for investment in health status in the long-run. This study could be used as a guideline and may be significant for future researchers and policy makers who aim to improve the life expectancy in developing countries.
BIG DATA: A REVOLUTION THAT WILL CHANGE THE EDUCATION LANDSCAPE

The recent advance in Information and Communication Technologies has resulted in a considerable increase in the amount of information that is being generated. This data revolution commonly known as ‘Big Data’ is, actually, one of the highest IT trends that is made use of in various domains and for a variety of purposes. This data revolution will not only have an effect on how individuals and organizations process and use information, but will also drive revolutionary changes in many fields. However, one of main the fields on which big data can have a great impact is education. The objective of this paper is, therefore, to explore the potential influence that this voluminous amount of data can have on the education landscape. In this respect, it was found out that big data can provide valuable real-time insights on how students acquire and digest knowledge. Moreover, it can be used to provide every individual student with a more customized, effective and engaging learning experience. Finally, it enables students, teachers and decisions makers to receive immediate feedback needed to enhance the learning/teaching process.
Comparison of Randomly Amplified Polymorphic DNA Analysis and Pulsed-Field Gel Electrophoresis for Typing of Moraxella catarrhalis Strains

ABSTRACT Randomly amplified polymorphic DNA (RAPD) and pulsed-field gel electrophoresis (PFGE) for the analysis of 13 Moraxella catarrhalis isolates, 11 successive strains isolated from sputa of five children and 2 isolates obtained the same day from twins, were compared. RAPD and PFGE both yielded nine types from the 13 isolates, showing a chronic colonization with one strain in three patients and a successive colonization with different strains in two patients. The promising results obtained with RAPD should be confirmed with a larger number of strains, but RAPD seems as suitable as PFGE for the typing ofM. catarrhalis.
Identification of an epidermal basement membrane defect in recessive forms of dystrophic epidermolysis bullosa by LH 7:2 monoclonal antibody: use in diagnosis

LH 7:2 is a monoclonal antibody that was raised against an extract of human epidermal cells and identifies an epitope within the lamina densa of the basement membrane of stratified squamous epithelia. Using indirect immunofluorescence we found intense labelling with LH 7:2 at the epidermal basement membrane (EBM) of normal skin, and in skin samples from patients with simplex, junctional, dominantly inherited dystrophic and acquired forms of epidermolysis bullosa (EB), as well as bullous pemphigoid. Staining was absent or only very faint in generalized recessive dystrophic EB (RDEB), and patchily reduced in the localized form of RDEB.
Investigation of the pharmacokinetics of celecoxib by liquid chromatography-mass spectrometry.

A new method for the quantification of celecoxib in human plasma based on reversed-phase high-performance liquid chromatography (HPLC) coupled to atmospheric pressure chemical ionization (APCI) mass spectrometry (MS) after liquid-liquid extraction is presented. The method is rapid, sensitive and highly selective. The retention time of celecoxib was 2.3 min. The limit of quantification was 5 microg/L. Rofecoxib was used as internal standard. After validation, the method was used to study the pharmacokinetic profile of celecoxib following administration of a single oral dose (200 mg) in 12 healthy volunteers. Since celecoxib should be metabolized primarily by cytochrome 2C9 (CYP2C9), a poor metabolizer (PM) for this cytochrome P450 enzyme was included in the study. Pharmacokinetic characteristics (mean +/- SD) of extensive metabolizers (EM) were t(max) 2.9+/-1.2h, c(max) 842+/-280 microg/L, AUC(infinity) 6246+/-2147 microg h/L and t(1/2) 7.8+/-2.7h. The area under the curve (AUC(infinity)) for the PM was 12561 microg h/L. However, we found no noticeable increase in half life in the PM (11.5 h) after a single dose of celecoxib.
Automobile security concerns

Automotive theft and hijacking are traditionally the major automobile security concerns. The Federal Bureau of Investigation (FBI) Uniform Crime Reports (UCR) state that the number of automobiles stolen each year fluctuated around 1,200,000 from 1997 to 2006 (Figure 1), without having a steady trend. Common ways of stealing cars include carjacking, breaking windows or jimmying locks to gain entry, deactivating the alarm or steering wheel lock by cutting wires, deceiving manufacturers to make a replacement key by providing specific information of automobiles, or (most frequently) keys left in the automobile by their careless owners. Admittedly these threats are low tech. Well-known automotive security features, such as alarms, entry lock, and transmission or wheel lock, prevent the threats to some extent.
Is the Gender Pay Gap in the US Just the Result of Gender Segregation at Work?

This study examines the gender wage gap between male and female workers in the US using a cross-section from the Current Population Survey (CPS) It shows that the extent of gender segregation by both industry and occupation is significantly greater than previously supposed. For the wage gap this creates problems of sample selection bias, of non-comparability between male and female employment. To address these problems the study uses a matching approach, which we also extend to a more recent methodological version with a yet stronger statistical foundation – Inverse Probability Weighted Regression Adjustment (IPWRA) – not previously used in related studies. Despite this, doubts remain about even these well founded and appropriate techniques in the presence of such strong gender segregation. To secure even greater precision we repeat the matching analysis for a small number of industries and occupations, each carefully selected for employing similar numbers of men and women. This is an approach that has not previously been explored in the relevant literature. The findings for the full sample are replicated at the level of industry and occupation, where comparability is more reliable. The study supports the view of the existing literature that the gender wage gap varies by factors such as age and parenthood. But it also finds that, even when these and other important "control" variables such as part-time working, industry and occupation are taken into account, a statistically significant gender wage gap remains.