Miracle-dz/UniFAR-FTUs huggingface dataset:
Distributed Optimal Control of Smart Electricity Grids With Congestion Management

In this paper, we consider the balancing problem in a hierarchical market-based structure for smart energy grids that is based on the Universal Smart Energy Framework. The large-scale introduction of renewable, intermittent energy sources in the power system can create a mismatch between the forecasted (day ahead) and the actual supply and demand. Without a proper control strategy, this deviation could lead to network overloads and commercial losses. We present a multilevel distributed optimal control formulation to the problem, in which the appliances of prosumers that can provide flexibility are optimally dispatched based on local information. The control strategy takes the capacity limitations of the distribution network into account. We provide example simulation results, obtained by distributed model predictive control.
LED Packaging for Lighting Applications: Design, Manufacturing and Testing

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Covariance Analyses of Self-Shielding Factor and Its Temperature Gradient for Uranium-238 Neutron Capture Reaction

Covariances of the self-shielding factor and its temperature gradient for the uranium-238 neutron capture reaction have been evaluated from the resonance parameter covariance matrix and the sensitivity of the self-shielding factor and its temperature gradient to the resonance parameters. The resonance parameters and their covariance matrix for uranium-238 were taken from JENDL-3.3, while the sensitivity coefficients were calculated by varying resonance parameters and temperature. A set of computer code modules has been developed for the calculation of the sensitivity coefficients at numerous resonance levels. The present result shows that the correlation among resonance parameters yields a substantial contribution to the standard deviations of the self-shielding factor and its temperature gradient. In addition to the standard deviations of these quantities, their correlation matrices in the JFS-3 70 group structure are also obtained.
Comparing autotransporter β-domain configurations for their capacity to secrete heterologous proteins to the cell surface

Monomeric autotransporters have been extensively used for export of recombinant proteins to the cell surface of Gram-negative bacteria. A bottleneck in the biosynthesis of such constructs is the passage of the outer membrane, which is facilitated by the β-domain at the C terminus of an autotransporter in conjunction with the Bam complex in the outer membrane. We have evaluated eight β-domain constructs for their capacity to secrete fused proteins to the cell surface. These constructs derive from the monomeric autotransporters Hbp, IgA protease, Ag43 and EstA and the trimeric autotransporter Hia, which all were selected because they have been previously used for secretion of recombinant proteins. We fused three different protein domains to the eight β-domain constructs, being a Myc-tag, the Hbp passenger and a nanobody or VHH domain, and assessed expression, membrane insertion and surface exposure. Our results show that expression levels differed considerably between the constructs tested. The constructs that included the β-domains of Hbp and IgA protease appeared the most efficient and resulted in expression levels that were detectable on Coomassie-stained SDS-PAGE gels. The VHH domain appeared the most difficult fusion partner to export, probably due to its complex immunoglobulin-like structure with a tertiary structure stabilized by an intramolecular disulfide bond. Overall, the Hbp β-domain compared favorably in exporting the fused recombinant proteins, because it showed in every instance tested a good level of expression, stable membrane insertion and clear surface exposure.
Prognostic utility of FDG PET/CT and bone scintigraphy in breast cancer patients with bone-only metastasis

Abstract We performed this retrospective clinical study to examine the prognostic power of bone scintigraphy (BS) and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in terms of overall survival (OS) of breast cancer with bone-only metastasis. We retrospectively evaluated 100 female invasive ductal breast cancer patients (mean age 48.1 years) with bone-only metastasis. Twenty-five patients had human epidermal growth factor receptor 2 (HER2)-positive tumors, 65 were estrogen receptor (ER) and/or progesterone receptor (PR)-positive, HER2-negative tumors, and 10 were triple negative tumors. The patients were treated properly with various treatments, including chemotherapy, radiotherapy, hormone, and bisphosphonate therapy, based on their clinical status. All patients underwent BS and FDG PET/CT at baseline and 1 year after treatment. The baseline and follow images were visually compared, and the patients were grouped as responders or nonresponders based on their images. OS was compared between the groups. The mean OS after the diagnosis of bone-only metastasis was 57.6 months. Fifty-one patients (51%) died within 5 years after diagnosis of metastasis. No difference in survival was evident between responders and nonresponders based on BS imaging data (P = .090). The response status based on PET imaging data waste only significant independent prognostic factor on multivariate analysis (P = .001). Survival was lower in nonresponders than in responders based on PET imaging (32.7% vs 66.4%; P < .001). Our findings suggest that the response status according to FDG PET imaging can be used to predict OS in breast cancer patients with bone-only metastasis.
Following transforming DNA in Helicobacter pylori from uptake to expression

Natural transformation is a potent driver for genetic diversification in bacterial populations. It involves exogenous DNA binding, uptake, transport and internalization into the cytoplasm, where DNA can be processed and integrated into the host chromosome. Direct visualisation of transforming DNA (tDNA) has been limited to its binding to the surface or, in the case of Gram‐negative species, to its entrance into the periplasm. We present here for the first time the direct visualisation of tDNA entering the bacterial cytoplasm. We used as a model the Gram‐negative pathogen Helicobacter pylori, characterised by a large intraspecies variability that results from high mutation rates and efficient horizontal gene transfer. Using fluorescently labelled DNA, we followed for up to 3 h the fate of tDNA foci formed in the periplasm and eventually internalised into the cytoplasm. By tracking at the single cell level the expression of a fluorescent protein coded by the tDNA, we show that up to 50% of the cells express the transforming phenotype. The overall transformation process in H. pylori, from tDNA uptake to expression of the recombinant gene, can take place in less than 1 h, without requiring a growth arrest, and prior to the replication of the chromosome.
DICE: Compressing DRAM caches for bandwidth and capacity

This paper investigates compression for DRAM caches. As the capacity of DRAM cache is typically large, prior techniques on cache compression, which solely focus on improving cache capacity, provide only a marginal benefit. We show that more performance benefit can be obtained if the compression of the DRAM cache is tailored to provide higher bandwidth. If a DRAM cache can provide two compressed lines in a single access, and both lines are useful, the effective bandwidth of the DRAM cache would double. Unfortunately, it is not straight-forward to compress DRAM caches for bandwidth. The typically used Traditional Set Indexing (TSI) maps consecutive lines to consecutive sets, so the multiple compressed lines obtained from the set are from spatially distant locations and unlikely to be used within a short period of each other. We can change the indexing of the cache to place consecutive lines in the same set to improve bandwidth; however, when the data is incompressible, such spatial indexing reduces effective capacity and causes significant slowdown. Ideally, we would like to have spatial indexing when the data is compressible and TSI otherwise. To this end, we propose Dynamic-Indexing Cache comprEssion (DICE), a dynamic design that can adapt between spatial indexing and TSI, depending on the compressibility of the data. We also propose low-cost Cache Index Predictors (CIP) that can accurately predict the cache indexing scheme on access in order to avoid probing both indices for retrieving a given cache line. Our studies with a 1GB DRAM cache, on a wide range of workloads (including SPEC and Graph), show that DICE improves performance by 19.0% and reduces energy-delay-product by 36% on average. DICE is within 3% of a design that has double the capacity and double the bandwidth. DICE incurs a storage overhead of less than 1KB and does not rely on any OS support.
STUDY OF SENSORY PARAMETERS OF NAAN USING LACTIC ACID PRODUCED FROM CORN COBS

The organic acids are occurring widely in nature and the lactic acid is one of them found in nature. Lactic acid is a weak acid, which can be broken down easily in water and other solvents. It has pleasant sour taste with little odor, and used for different food applications such as in syrups, jams, jellies and soft drinks. It has long been used by the food industry as an additive for preservation, flavor and acidity. Lactic acid has been considered to be the safe for health because it does not give any residual undesirable element in food. In the present study, the lactic acid obtained from corn cobs (Food waste material) was used in different doses and it was found that the sensory characteristics of the naan were not affected. The storage time (0,24,48,72 and 96 hours) and different treatments of lactic acid 0%,0.1%,0.3%, 0.4%) significantly affected the external characters like color of crust, taste, texture, flavor, Chewability, foldingability and overall acceptability of naan, while their interaction was found to be non-significant for these characteristics.
Gli family zinc finger 1 is associated with endothelin receptor type B in Hirschsprung disease

Hirschsprung disease (HSCR) is a newborn colorectal disease characterized by an absence of ganglia in the distal gut. Hedgehog (Hh) and endothelin signaling serve important roles in gastrointestinal tract formation. Alterations in the signaling pathways disrupt the development of enteric neural crest cells (ENCCs). It is not known whether there is any coordination between these pathways in the pathogenesis of HSCR. In the present study, tissue samples from 35 patients with HSCR, including stenotic aganglionosis gut and normal ganglionic gut, were obtained. The expression of Gli family zinc finger 1 (Gli1) and endothelin receptor type B (EDNRB) was determined using reverse transcription-quantitative polymerase chain reaction, immunohistochemistry and western blotting. In addition, the SK-N-SH cell line was used to investigate the association between Hh signaling and the expression of EDNRB. The results revealed aberrant expression of Gli1 in the aganglionic segments, as well as decreased expression of Gli1 in tissues from 7 patients with HSCR exhibited, whereas tissues from 9 patients with HSCR exhibited increased Gli1 expression compared with the expression in the normal tissues. There was a negative association between EDNRB expression and Gli1 expression in the same sample. Knockdown of Gli1 by small interfering RNA and inhibition of Hh signaling by Vismodegib in SK-N-SH cells increased EDNRB expression. By contrast, upregulation of Gli1 expression by plasmids and activation of Hh signaling by Purmorphamine decreased EDNRB expression. Furthermore, premature enteric ganglia were observed in 4 patients with HSCR with decreased Gli1 expression. Thus, the results of the present study suggest that altered Gli1 expression negatively regulates EDNRB expression in patients with HSCR. The increased expression of EDNRB induced by decreased Gli1 expression may represent a novel mechanism in HSCR.
Prioritizing key success factors of software projects using fuzzy AHP

The main purpose of most software projects is to build an effective and efficient product that satisfies the user's requirements under constraints of basic available resources. Thus, recognizing the critical features that may affect developing the application could be imperative. In this study, we apply the fuzzy analytic hierarchy process (AHP) to the issue of ordering key success factors (KSFs) for software development projects. To do this, we first simplified the constrained fuzzy AHP method, and then from systematic literature reviews, a preliminary list of potential KSFs that influences software development projects was identified and compiled. Subsequently, on the basis of the criteria of the frequency of citation in previous studies, closely related and similar functionality, the preliminary list was consolidated into a final set of 15 possible KSFs and considered at 4 perspectives of project management, development team, product, and processes. Pairwise comparisons, required by fuzzy AHP method, were done by 22 experienced professional internal stakeholders to determine the preference weights of factors and perspectives in terms of natural language expressions. The results reveal that project management has the highest importance in comparison with other 3 perspectives, and the factor of efficient project management skills/methodologies is the major. The procedure used in this paper is simple and accurate to implement and concludes both relative weights and rankings of alternatives in a fuzzy environment.
Metabolomics analysis reveals an effect of homocysteine on arachidonic acid and linoleic acid metabolism pathway

An increase in serum homocysteine level has been associated with an increased risk of vascular disease; however, the biochemical mechanisms that underlie these effects remain largely unknown. The present study aimed to use high-performance liquid chromatography-mass spectrometry (HPLC-MS) to demonstrate the effects of serum homocysteine on human blood metabolites. A total of 75 fasting serum samples were investigated in the present study. Using a threshold of 15 µmol/l serum homocysteine level, samples were divided into high- and low-homocysteine groups, and the serum extracts were analyzed with an HPLC-MS-based method. A total of 269 features exhibited significant differences and correlation with serum homocysteine levels in the electrospray ionization-positive [ESI(+)] mode, and 69 features were identified in the ESI(−) mode between the two groups. The principal component analysis plot revealed a separation between the high- and the low-homocysteine groups. Metabolite set enrichment analysis identified arachidonic acid metabolism and linoleic acid metabolism as the two pathways with significantly enriched differences. These results revealed that arachidonic acid and linoleic acid metabolism may be associated with serum homocysteine levels and may be involved in homocysteine-induced vascular disease.
Influence of experimental parameters on iron oxide nanoparticle properties synthesized by thermal decomposition: size and nuclear magnetic resonance studies

A study of the experimental conditions to synthesize monodisperse iron oxide nanocrystals prepared from the thermal decomposition of iron(III) acetylacetonate was carried out in the presence of surfactants and a reducing agent. The influence of temperature, synthesis time and surfactant amounts on nanoparticle properties is reported. This investigation combines relaxometric characterization and size properties. The relaxometric behavior of the nanomaterials depends on the selected experimental parameters. The synthesis of iron oxide nanoparticles with a high relaxivity and a high saturation magnetization can be obtained with a short reaction time at high temperature. Moreover, the influence of surfactant concentrations determines the optimal value in order to produce iron oxide nanoparticles with a narrow size distribution. The optimized synthesis is rapid, robust and reproductive, and produces nearly monodisperse magnetic nanocrystals.
On the issue of camera calibration with narrow angular field of view

This paper considers the issue of calibrating a camera with narrow angular field of view using standard, perspective methods in computer vision. In doing so, the significance of perspective distortion both for camera calibration and for pose estimation is revealed. Since narrow angular field of view cameras make it difficult to obtain rich images in terms of perspectivity, the accuracy of the calibration results is expectedly low. From this, we propose an alternative method that compensates for this loss by utilizing the pose readings of a robotic manipulator. It facilitates accurate pose estimation by nonlinear optimization, minimizing reprojection errors and errors in the manipulator transformations at the same time. Accurate pose estimation in turn enables accurate parametrization of a perspective camera.
Phase I Study of LY2940680, a Smo Antagonist, in Patients with Advanced Cancer Including Treatment-Naïve and Previously Treated Basal Cell Carcinoma

Purpose: The purpose of this study was to determine a recommended phase II dose and schedule of LY2940680 (taladegib) for safe administration to patients with locally advanced/metastatic cancer. Experimental Design: This was a phase I, multicenter, open-label study of oral LY2940680. The maximum tolerable dose (MTD) was determined using a 3+3 design, the dose was confirmed, and then treatment-naïve and previously hedgehog (Hh)-inhibitor–treated patients with basal cell carcinoma (BCC) were enrolled. Results: Eighty-four patients were treated (dose escalation, n = 25; dose confirmation, n = 19; and BCC dose expansion, n = 40). Common treatment-emergent adverse events were dysgeusia [41 (48.8%)], fatigue [40 (47.6%)], nausea [38 (45.2%)], and muscle spasms [34 (40.5%)]. Four patients experienced events (3 were grade 3; 1 was grade 2) that were considered dose-limiting toxicities (DLT). The MTD was determined to be 400 mg because of DLTs and dose reductions. Pharmacokinetic analyses showed no clear relationship between exposure and toxicity. Analysis of Gli1 mRNA from skin biopsies from unaffected areas suggested that all doses were biologically active [inhibition median of 92.3% (80.9% to 95.7%)]. All clinical responses (per RECIST 1.1) were in patients with BCC (n = 47); the overall and estimated response rate was 46.8% (95% confidence interval, 32.1%–61.9%). Responses were observed in patients previously treated with Hh therapy (11/31) and in Hh treatment–naïve (11/16) patients. Conclusions: LY2940680 treatment resulted in an acceptable safety profile in patients with advanced/metastatic cancer. Clinical responses were observed in patients with locally advanced/metastatic BCC who were previously treated with Hh therapy and in Hh treatment–naïve patients. Clin Cancer Res; 24(9); 2082–91. ©2018 AACR.
Life Chaos and Perceived Social Support Among Methamphetamine-Using Men Who Have Sex With Men Engaging in Transactional Sexual Encounters

ABSTRACT Objective: Social support and life chaos have been inversely associated with increased risk of HIV infection. The purpose of this study was to explore among a sample of HIV-negative methamphetamine-using men who have sex with men (MSM) the association between engaging in transactional sex, life chaos, and low social support. Methods: HIV-negative methamphetamine-using MSM completed an online questionnaire between July and October 2012 about recent substance use and sexual behavior. Bivariate and multivariate tests were used to obtain statistically significant associations between demographic characteristics, engaging in transactional sex, life chaos, and the participants' perception of their social support. Results: Of the 325 participants, 23.7% reported engaging in transactional sex, 45.2% reported high life chaos, and 53.5% reported low perceived social support. Participants who engaged in transactional sex were more likely to have high life chaos than participants who did not (aOR = 1.70, 95% CI = [1.01, 2.84]); transactional sex was not associated with social support. Participants with high life chaos were more out about their sexual orientation (aOR = 2.29, 95% CI = [1.18, 4.42]) and more likely to perceive they had low social support (aOR = 3.78, 95% CI = [2.31, 6.22]) than participants with low life chaos. Non-Latinos perceived they had less social support than Latinos (aOR = 0.48, 95% CI = [0.25, 0.92]). Conclusions: Methamphetamine-using MSM engaging in transactional sex experience more life chaos than those who do not engage in transactional sex. Outness, perceived social support, and ethnicity are associated with life chaos.