Miracle-dz/UniFAR-FTUs huggingface dataset:
Real Time MODBUS Transmissions and Cryptography Security Designs and Enhancements of Protocol Sensitive Information

Information technology (IT) security has become a major concern due to the growing demand for information and massive development of client/server applications for various types of applications running on modern IT infrastructure. How has security been taken into account and which paradigms are necessary to minimize security issues while increasing efficiency, reducing the influence on transmissions, ensuring protocol independency and achieving substantial performance? We have found cryptography to be an absolute security mechanism for client/server architectures, and in this study, a new security design was developed with the MODBUS protocol, which is considered to offer phenomenal performance for future development and enhancement of real IT infrastructure. This study is also considered to be a complete development because security is tested in almost all ways of MODBUS communication. The computed measurements are evaluated to validate the overall development, and the results indicate a substantial improvement in security that is differentiated from conventional methods.
How to model a TCP/IP network using only 20 parameters

Most simulation models for data communication networks encompass hundreds of parameters that can each take on millions of values. Such models are difficult to understand, parameterize and investigate. This paper explains how to model a modern data communication network concisely, using only 20 parameters. Further, the paper demonstrates how this concise model supports efficient design of simulation experiments. The model has been implemented as a sequential simulation called MesoNet, which uses Simulation Language with Extensibility (SLX). The paper discusses model resource requirements and the performance of SLX. The model and principles delineated in this paper have been used to investigate parameter spaces for large (hundreds of thousands of simultaneously active flows), fast (hundreds of Gigabits/ second) simulated networks under a variety of congestion control algorithms.
Location as an Analysis and Design Metaphor in Work Settings with Complex Cooperations

Metaphor in Work Settings with Complex Cooperations Stefan Roock, Ingrid Wetzel, Henning Wolf, Heinz Züllighoven 1roock@informatik.uni-hamburg.de wetzel@informatik.uni-hamburg.de 1wolf@informatik.uni-hamburg.de zuelligh@informatik.uni-hamburg.de Software Engineering Group Dept. of Computer Science University of Hamburg Vogt-Kölln-Straße 30 +49 40 5494 2306 Organizations are subdivided into units. The services or products the organization provides as a whole are performed by employees of different units in close cooperation. This cooperative work is supported by a sophisticated environment. Current software systems normally lack this aspect by providing system support merely on the perspective of separated single users applying the desktop metaphor. This article claims that in work settings with complex cooperations the work environments need to be analyzed and captured in system design. The paper presents an approach using a wide range of different design documents for analyzing joint tasks in organizations and responsibilities and work environments of units. It uses the location metaphor for designing software systems capturing certain aspects of the real work environments.
Review of interventions to improve pragmatic language skills in children with behaviour and attention problems

Pragmatic language is the socially appropriate use of language in accordance with the context in which interactions take place. In view of this, deficiencies in pragmatic skills have a significant impact on psychosocial adjustment. Recent evidence has shown that children who present behavioural problems usually display these linguistic difficulties as well. The aim of this work is to analyse different interventions intended to improve the pragmatic skills of children with behavioural and/or attention problems and discuss the evidence of the results. After a literature search, nine interventions were found: five aimed at children with behavioural problems and four intended for children with attention and hyperactivity problems. The results showed that, while the characteristics of the interventions varied considerably, they generally achieved positive results, especially when they were implemented using a systemic approach with other educational agents participating (such as the family or peer group). Even so, the lack of available evidence suggests that further research into evidence-based interventions to help children improve their pragmatic, communicative, and social competences is required.
Invited Paper: Low-Cost Telerehabilitation

The hardware and software costs of telerehabilitation systems are summarized. Several hardware and software examples are given in order to look at what has been done, and what can be done in the future. At present only a single low-cost telerehabilitation system (developed at the University of California at Irvine) has been identified. The author does not claim this to be a comprehensive review, rather an attempt to motivate the reader to look at ways to overcome cost barriers to widespread telerehabilitation use.
The lattice as allosteric effector: Structural studies of αβ- and γ-tubulin clarify the role of GTP in microtubule assembly

GTP-dependent microtubule polymerization dynamics are required for cell division and are accompanied by domain rearrangements in the polymerizing subunit, αβ-tubulin. Two opposing models describe the role of GTP and its relationship to conformational change in αβ-tubulin. The allosteric model posits that unpolymerized αβ-tubulin adopts a more polymerization-competent conformation upon GTP binding. The lattice model posits that conformational changes occur only upon recruitment into the growing lattice. Published data support a lattice model, but are largely indirect and so the allosteric model has prevailed. We present two independent solution probes of the conformation of αβ-tubulin, the 2.3 Å crystal structure of γ-tubulin bound to GDP, and kinetic simulations to interpret the functional consequences of the structural data. These results (with our previous γ-tubulin:GTPγS structure) support the lattice model by demonstrating that major domain rearrangements do not occur in eukaryotic tubulins in response to GTP binding, and that the unpolymerized conformation of αβ-tubulin differs significantly from the polymerized one. Thus, geometric constraints of lateral self-assembly must drive αβ-tubulin conformational changes, whereas GTP plays a secondary role to tune the strength of longitudinal contacts within the microtubule lattice. αβ-Tubulin behaves like a bent spring, resisting straightening until forced to do so by GTP-mediated interactions with the growing microtubule. Kinetic simulations demonstrate that resistance to straightening opposes microtubule initiation by specifically destabilizing early assembly intermediates that are especially sensitive to the strength of lateral interactions. These data provide new insights into the molecular origins of dynamic microtubule behavior.
The Business Value of Recommendations: A Privacy-Preserving Econometric Analysis

We study the effectiveness of different types of mobile recommendations and their impact on consumers’ utility and product demand, using a privacy-preserving econometric analysis. We find that an increase by 10% in the number of recommendations raises demand by about 6.7%. Our findings highlight the importance of “in-the-moment” marketing. In particular, trending recommendations that provide “in-the-moment” content have a much stronger effect compared to traditional recommendations. This effect is stable across various levels of popularity, whereas traditional recommendations contribute to the rich-get-richer phenomenon. We also examine various moderating effects; for instance, we find that recommendations based on just the novelty of the alternative do not have a significant effect but novel alternatives accrue greater benefits from recommendations when the quality of the item is also taken into consideration. We validate the robustness of our findings using instruments based on a deep learning model as well as different treatment-effects estimators.
User Interface Design of a SLAM-based Handheld Augmented Reality Work Support System (マルチメディア・仮想環境基礎)

Handheld augmented reality (HAR) is an expanding novel technology and user studies are very important part for driving its design activities. In order to form design guidelines and principles, it is important to gain better understanding of the usage of HAR systems. This paper describes the iterative design process of a state-of-the-art pragmatic simultaneous localization and mapping (SLAM) based HAR work support system prototype. As a contribution, results from the user studies of the proposed system are presented as well as category-specific design guidelines for similar kinds of HAR SLAM-based systems. Keyword: augmented reality, work support system, SLAM, user interface design
Effects of Employees' Work Values and Organizational Management on Corporate Performance for Chinese and Taiwanese Construction Enterprises

Through questionnaire surveys, this study explored the discrepancies in work values and organizational management between employees and cadre members of construction enterprises on the two sides of the Taiwan Strait. Statistical methods including data reliability, regression analysis, and tests of significance were utilized for modelling a case study. The findings of this study included: (1) in terms of work values, employees from China focused on their lives “at present”, while those from Taiwan focused on their lives “in the future”, expecting to improve the quality of their lives later on through advanced studies and promotion; (2) according to the data obtained from the questionnaires, the answers regarding income and welfare in terms of work values and satisfaction were contradictory on the two sides of the Strait, which could be interpreted in terms of influence from society; and (3) there was a significant influence of organizational management on employees’ intentions to resign. If enterprises could improve current organizational management systems, their employees’ work attitudes would be improved and the tendency to resign would be reduced.
Kinematic ICP for Articulated Template Fitting

In this paper, we present an efficient optimization method to adapt an articulated 3D template model to a full or partial 3D mesh. The well-known ICP algorithm is enhanced to fit a generic template to a target mesh. Each iteration jointly refines the parameters for global rigid alignment, uniform scale as well as the rotation parameters of all joint angles. The articulated 3D template model is based on the publicly available SCAPE data set, enhanced with automatically learned rotation centers of the joints and Linear Blend Skinning weights for each vertex. In two example applications we demonstrate the effectiveness of this computationally efficient approach: pose recovery from full meshes and pose tracking from partial depth maps.
Immunomodulatory effects of ethanol extract of germinated ice plant (Mesembryanthemum crystallinum)

The purpose of this study was to investigate the immunomodulatory activity of ice plant (Mesembryanthemum crystallinum) extract (IPE) in vitro and in vivo. Raji (a human B cell line) and Jurkat (a human T cell line) cells were treated with various doses of IPE and cell proliferation was measured by WST assay. Results showed that IPE promoted the proliferation of both Raji and Jurkat cells in a dose-dependent manner. IPE also enhanced IL-6 and TNF-α production in macrophages in the presence of lipopolysaccharide (LPS), although IPE alone did not induce cytokine production. Moreover, IPE treatment upregulated iNOS gene expression in macrophages in a time- and dose-dependent manner and led to the production of nitric oxide in macrophages in the presence of IFNγ. In vivo studies revealed that oral administration of IPE for 2 weeks increased the differentiation of CD4+, CD8+, and CD19+ cells in splenocytes. These findings suggested that IPE has immunomodulatory effects and could be developed as an immunomodulatory supplement.
Evaluation of Eight Different Clinical Staging Systems Associated with Overall Survival of Chinese Patients with Hepatocellular Carcinoma

Background: Hepatocellular carcinoma (HCC) is a common cancer in China, an area of high hepatitis B virus (HBV) infection. Although several staging systems are available, there is no consensus on the best classification to use because multiple factors, such as etiology, clinical treatment and populations could affect the survival of HCC patients. Methods: This study analyzed 743 HBV-related Chinese HCC patients who received surgery first and evaluated the predictive values of eight different commonly used staging systems in the clinic. Results: The overall 1-, 3-, 5-year survival rates and a median survival were 91.5%, 70.3%, 55.3% and 72 months respectively. Barcelona Clinic Liver Cancer (BCLC) staging systems had the best stratification ability and showed the lowest Akaike information criterion (AIC) values (2896.577), followed by tumor-node-metastasis 7th (TNM 7th) (AIC = 2899.980), TNM 6th (AIC = 2902.17), Japan integrated staging score (AIC = 2918.085), Tokyo (AIC = 2938.822), Cancer of the Liver Italian Program score (AIC = 2941.950), Chinese University Prognostic Index grade (AIC = 2962.027), and Okuda (AIC = 2979.389). Conclusions: BCLC staging system is a better staging model for HBV infection patients with HCC in Chinese population among the eight currently used staging systems. These identifications afford a large group of Chinese HCC patients with HBV infection and could be helpful to design a new staging system for a certain population.
Brain-shift aware risk map for Deep Brain Stimulation Planning

In Deep Brain Stimulation surgery, the efficiency of the procedure heavily relies on the accuracy of the placement of the stimulating electrode. Meanwhile, the effectiveness of the placement is difficult due to brain shifts occurring during and after the procedure. We propose an approach to overcome the limitations of current planning software that ignores brain shift. In particular, we consider the motion of vascular structures in order to reduce risks of dissecting a vessel during the procedure. Facing the difficulty to produce an exact brain shift prediction, we propose to build a brain shift aware risk map which embeds the vascular motion risk. This risk map is extrapolated using simulation from clinical studies that provide statistics on the displacement of anatomical landmarks during the procedure. Risk maps can be directly integrated into automatic path planning algorithms to better predict optimal electrode trajectories. The method relies on a physics-based simulation that takes into account brain deformation, electrode placement, cerebrospinal fluid, and vascular motion. The goal is to reproduce the spread of brain shift situations that are noted in clinical studies. Preliminary results show that it is possible to compute safe electrode trajectories even in case of brain shift and yet optimal regarding the placement within the targeted area.
Sleep‐dependent activity of T cells and regulatory T cells

A number of immunological functions are dependent on circadian rhythms and regular sleep. This has impact on the type and magnitude of immune responses following antigenic challenge, for example in vaccination. Little is known about the underlying mechanisms. One possibility may be the circadian and sleep‐dependent modulation of CD4+CD25‐ T cell responses by CD4+CD25+ natural regulatory T cells (nTreg). In a variety of studies, nTreg have been shown to regulate T cell responses negatively. Thus, we investigated the influence of sleep and circadian rhythm on the number and function of nTreg as well as on the function of CD4+CD25‐ T cells. Seven healthy young men were examined under defined conditions on two occasions, i.e. during sleep and sleep deprivation. Venous blood was drawn periodically; numbers of nTreg, suppressive activity of nTreg, interleukin‐2 production and proliferation of CD4+CD25‐ T cells were explored in vitro. nTreg counts revealed a significant circadian rhythm with highest levels during the night (mean 95 nTreg/µl) and lowest levels during the day (mean 55 nTreg/µl). During normal sleep, the suppressive activity of nTreg was highest at 02.00 h and somewhat lower at 15.00 h. Surprisingly, almost no suppressive activity was present at 07.00 h. Deprivation of sleep abrogated this rhythm. CD4+CD25– T cell proliferation was dampened significantly by sleep deprivation. This is the first study in human cells to show that nTreg number and function follow a rhythm across the 24‐h period. Furthermore, sleep deprivation severely disturbs the functional rhythm of nTreg and CD4+CD25– T cells.
Competitive Food Sales in Schools and Childhood Obesity

The vast majority of American middle schools and high schools sell what are known as “competitive foods,” such as soft drinks, candy bars, and chips, to children. The relationship between consumption of sugar-sweetened drinks and snacks and childhood obesity is well established, but it remains unknown whether competitive food sales in schools are related to unhealthy weight gain among children. The authors examined this association using data from the Early Childhood Longitudinal Study, Kindergarten Class. Employing fixed effects models and a natural experimental approach, they found that children’s weight gain between fifth and eighth grades was not associated with the introduction or the duration of exposure to competitive food sales in middle school. Also, the relationship between competitive foods and weight gain did not vary significantly by gender, race/ethnicity, or family socioeconomic status, and it remained weak and insignificant across several alternative model specifications. One possible explanation is that children’s food preferences and dietary patterns are firmly established before adolescence. Also, middle school environments may dampen the effects of competitive food sales because they so highly structure children’s time and eating opportunities.
Structured query suggestion for specialization and parallel movement: effect on search behaviors

Query suggestion, which enables the user to revise a query with a single click, has become one of the most fundamental features of Web search engines. However, it is often difficult for the user to choose from a list of query suggestions, and to understand the relation between an input query and suggested ones. In this paper, we propose a new method to present query suggestions to the user, which has been designed to help two popular query reformulation actions, namely, specialization (e.g. from "nikon" to "nikon camera" ) and parallel movement (e.g. from "nikon camera" to "canon camera"). Using a query log collected from a popular commercial Web search engine, our prototype called SParQS classifies query suggestions into automatically generated categories and generates a label for each category. Moreover, SParQS presents some new entities as alternatives to the original query (e.g. "canon" in response to the query "nikon"), together with their query suggestions classified in the same way as the original query's suggestions. We conducted a task-based user study to compare SParQS with a traditional "flat list" query suggestion interface. Our results show that the SParQS interface enables subjects to search more successfully than the flat list case, even though query suggestions presented were exactly the same in the two interfaces. In addition, the subjects found the query suggestions more helpful when they were presented in the SParQS interface rather than in a flat list.
A hybrid approach for Robust Traffic Engineering

Phenomenal growth of Internet applications in recent years have made it difficult to forecast traffic patterns. Daily and weekly Internet traffic pattern shows that network is vulnerable to malicious attacks, flash crowds and distributed denial of service attacks (DDoS). In this paper we present a Robust Routing Technique (RRT) under dynamic traffic demand condition. Our simulation results are compared with OSPF-TE. Key feature of RRT is its convergence to generate the solution. It converges quickly to produce the simulation result on the family of topologies we consider in this paper. We are aiming a hybrid approach by combining best of proactive and reactive routing approaches in the RRT.
Psychometric properties of persian version of academic success inventory for college students

Background: The students' average achievement test scores cannot predict the students' academic success appropriately. Objectives: This study aimed to determine the psychometric properties of Persian version of the Academic Success Inventory for College Students (ASICS). Methods: The study was conducted in four steps of translation, face and content validity, exploratory factor analysis, and reliability assessment. Results: The final version of the Persian version has 38 items. Ten factors with an eigenvalue more than one were extracted. Internal consistency of the scale was 0.75. Item-total correlation ranged from 0.33 to 0.7 for all items and the mean item-total correlation was between 2.20 and 2.90. Conclusion: The Persian version of ASICS showed appropriate psychometric properties. It can be used to assess the academic success of Iranian college students.
At What Price? A Cost-Effectiveness Analysis Comparing Trial of Labour after Previous Caesarean versus Elective Repeat Caesarean Delivery

Objective To perform an economic evaluation on the costs and maternal health consequences associated with a trial of labour (TOL) after one previous caesarean delivery compared with elective repeat caesarean delivery (ERCD) for low risk women in an Irish context. Methods Incidence rates of adverse maternal health outcomes following a TOL and ERCD were unavailable for Ireland, therefore representative estimates were derived from a review of international literature and pooled data. Delivery/procedure costs were micro-costed based on information derived from primary data collection. Using a hypothetical cohort of 1,000 women, a cost-effectiveness analysis was performed where the measure of health gain was quality-adjusted life years (QALYs) over a six-week time horizon. Results TOL was substantially less expensive than ERCD (€1,744.48 versus €4039.87 respectively), and QALYs were modestly higher (0.84 versus 0.70). Despite maternal morbidities being twice as likely following a failed TOL than an ERCD, a TOL was found to be the most cost-effective method of delivery. The main advantages of a TOL were reduced length of stay in hospital and higher utility following a vaginal delivery. Our findings were supported by probabilistic sensitivity analysis, and net benefit analysis confirmed that the probability that a TOL was cost-effective was 100%. Conclusions In light of the revised NICE guidelines permitting caesarean delivery upon maternal request, clinicians need to be well informed of the benefits and risks of TOL among low risk women. Ideally, clinician-patient discourse would address differences in length of hospital stay, postpartum recovery time and potential obstetric complications.