Miracle-dz/UniFAR-FTUs huggingface dataset:
Value of diagnostic tools for myocardial ischemia used in routine clinical practice to predict cardiac events in patients with type 2 diabetes mellitus: a prospective study.

OBJECTIVE To analyze tests used in routine clinical practice for the diagnosis of myocardial ischemia to predict the development of cardiac events in type 2 diabetic patients. METHODS The occurrence of cardiac events (new myocardial infarct, myocardial re-vascularization procedures, congestive heart failure, acute pulmonary edema, sudden death, and death after myocardial infarction or pulmonary edema) were prospectively assessed in a cohort of 135 type 2 diabetic patients after up to seven years of follow-up. At baseline, coronary artery disease was assessed by the WHO cardiovascular questionnaire, resting electrocardiogram, and stress myocardial scintigraphy. RESULTS Forty-eight cardiac events were observed in 41 patients (10.5 events/100 patients-year). In a Cox's proportional-hazard model only the presence of symptoms of coronary artery disease on the WHO cardiovascular questionnaire alone (RR = 2.13, 95% CI 1.11-4.07, P= 0.022) or in combination with abnormalities on resting ECG (RR= 2.03, 95% CI 1.05-3.92, P= 0.034) or on myocardial scintigraphy (RR= 1.89, 95% CI 1.001-3.57, P= 0.050) predicted cardiac events, adjusted for fasting plasma glucose, mean blood pressure, body mass index, peripheral vascular disease and diabetic nephropathy. CONCLUSION The WHO cardiovascular questionnaire, a simple tool for the diagnosis of coronary artery disease, is a significant predictor of cardiac events in type 2 diabetic patients.
Optimizing lexical and N-gram coverage via judicious use of linguistic data

I study the effect of various types and amounts of North American Business language data on the quality of the derived vocabulary, and use my ﬁndings to derive an improved ranking of the words, using only 19% of the NAB corpus. I then study the conﬂicting effects of increased vocabulary size on a speech recognizer’s accuracy, and use the result to pick an optimal vocabulary size. A similar analysis of ngram coverage yields a very different outcome, with the best system being the one based on the most data.
Increased levels of neutrophil extracellular trap remnants in the serum of patients with rheumatoid arthritis

Neutrophil extracellular traps (NETs) comprise a unique form of non‐apoptotic cell death exhibited by neutrophils, which occurs in a stepwise process termed NETosis. It has been postulated that NETosis plays an important role in the pathogenesis of autoimmune disorders. The aim of this study was to evaluate serum levels of NET remnants in patients with rheumatoid arthritis (RA), as well as potential associations between NET remnants and indicators of RA.
Learning-based super-resolution via Canonical Correlation Analysis

The task of image super-resolution is to up sample a low resolution (LR) image while recovering sharp edges and high frequency details. In this paper, a single image super-resolution algorithm via canonical correlation analysis (CCA) is proposed. This method is based on the assumption that the corresponding LR and high resolution (HR) images have high correlation coefficients when transformed into a special space. The proposed approach includes two stages: training and testing. In the training stage, a couple of canonical bases for transformation are calculated with the prepared coupled training sets. In the testing stage, the HR image can be recovered by using the canonical bases obtained in the training stage. In addition, an iterative back projection algorithm is used to further improve the image quality. The experiments demonstrate that our algorithm can reconstruct richer details, with fewer artifacts. Moreover, this algorithm is of less complexity.
Wireless Technology in Industrial Networks

With the success of wireless technologies in consumer electronics, standard wireless technologies are envisioned for the deployment in industrial environments as well. Industrial applications involving mobile subsystems or just the desire to save cabling make wireless technologies attractive. Nevertheless, these applications often have stringent requirements on reliability and timing. In wired environments, timing and reliability are well catered for by fieldbus systems (which are a mature technology designed to enable communication between digital controllers and the sensors and actuators interfacing to a physical process). When wireless links are included, reliability and timing requirements are significantly more difficult to meet, due to the adverse properties of the radio channels. In this paper, we thus discuss some key issues coming up in wireless fieldbus and wireless industrial communication systems: 1) fundamental problems like achieving timely and reliable transmission despite channel errors; 2) the usage of existing wireless technologies for this specific field of applications; and 3) the creation of hybrid systems in which wireless stations are incorporated into existing wired systems.
A new method for estimation of losses in inverter-fed induction machines including electrical insulation losses

This paper presents a new method for estimation of losses in inverter-fed induction machines. The estimated losses consists of core losses, Ohmic losses and electrical insulation losses. Output voltage of the inverter supplying induction machine contains a number of harmonics which increases the losses and stress on the insulations within the machine. These losses are compared in inverter-fed and line-start induction machines. In order to validate the results of the proposed method it is compared with the results of finite elements method and experimental results and reasonable agreement are achieved.
Permutation Tableaux and the Dashed Permutation Pattern 32-1

We give a solution to a problem posed by Corteel and Nadeau concerning permutation tableaux of length $n$ and the number of occurrences of the dashed pattern 32–1 in permutations on $[n]$. We introduce the inversion number of a permutation tableau. For a permutation tableau $T$ and the permutation $\pi$ obtained from $T$ by the bijection of Corteel and Nadeau, we show that the inversion number of $T$ equals the number of occurrences of the dashed pattern 32–1 in the reverse complement of $\pi$. We also show that permutation tableaux without inversions coincide with L-Bell tableaux introduced by Corteel and Nadeau.
nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer.

UNLABELLED Nanoparticle albumin-bound (nab)-paclitaxel, an albumin-stabilized paclitaxel formulation, demonstrates clinical activity when administered in combination with gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma (PDA). The limited availability of patient tissue and exquisite sensitivity of xenografts to chemotherapeutics have limited our ability to address the mechanistic basis of this treatment regimen. Here, we used a mouse model of PDA to show that the coadministration of nab-paclitaxel and gemcitabine uniquely demonstrates evidence of tumor regression. Combination treatment increases intratumoral gemcitabine levels attributable to a marked decrease in the primary gemcitabine metabolizing enzyme, cytidine deaminase. Correspondingly, paclitaxel reduced the levels of cytidine deaminase protein in cultured cells through reactive oxygen species-mediated degradation, resulting in the increased stabilization of gemcitabine. Our findings support the concept that suboptimal intratumoral concentrations of gemcitabine represent a crucial mechanism of therapeutic resistance in PDA and highlight the advantages of genetically engineered mouse models in preclinical therapeutic trials. SIGNIFICANCE This study provides mechanistic insight into the clinical cooperation observed between gemcitabine and nab-paclitaxel in the treatment of pancreatic cancer.
Classification of G-Protein Coupled Receptors , Based on Their Specific Ligand Coupling Patterns

Functional identification of G-Protein Coupled Receptors (GPCRs) is one of the current focus areas of pharmaceutical research. Although thousands of GPCR sequences are known, many of them remain as orphan sequences (the activating ligand is unknown). Therefore, classification methods for automated characterization of orphan GPCRs is imperative. In this study, for predicting Level 2 Subfamilies of Amine GPCRs, a novel method for obtaining fixed length feature vectors, based on the existence of activating ligand specific patterns, has been developed and utilized for a Support Vector Machine (SVM)-based classification. Our method classifies Level 2 Subfamilies of Amine GPCRs with a high predictive accuracy of 97.02% in a ten-fold cross validation test. This implies that there is a non-promiscuous relationship between the specific binding of GPCRs into their ligands and their functional classification. The presented machine learning approach, bridges the gulf between the excess amount of GPCR sequence data and their poor functional characterization.
Non-cooperative games with confirmed proposals

We propose a bargaining process as a way of playing and solving non cooperative games. We focus on social dilemma situations and show that sequential proposals which, if confirmed by players, determine real play, may give rise to equilibrium outcomes which differ from the standard non cooperative solution. Specifically, we show that, under standard assumptions, in a prisoners’ dilemma with confirmed proposals, there is a unique confirmed agreement between players to behave cooperatively. In these games the equilibrium strategy can be unique even though the strategy space of each of the two players and the stages of the game itself are infinite. The experimental evidence obtained on this setup strongly confirms our theoretical predictions, given that almost all the pairs in the lab reach a cooperation agreement. Our specific bargaining structure seems to lead to even more cooperation than does an almost infinitely (indefinitely) repeated game which we studied in the lab for comparison purposes. JEL classification: C72; C73; C91.
Information System for Graphological Identification

In this paper an automated information system is presented, that classifies scripts to corresponding writers using graphology. The methodology is based on the idea of creating a representative of each alphabet symbol in each script via proper fitting of all realizations of the specific symbol in it. The decision for writer identification is based on pair-wise comparisons of statistical quantities computed for all representatives. The system was applied to ancient Greek inscriptions of classical era which were correctly attributed to 6 different hands.
Optimizing XML querying using type-based document projection

XML data projection (or pruning) is a natural optimization for main memory query engines: given a query Q over a document D, the subtrees of D that are not necessary to evaluate Q are pruned, thus producing a smaller document D'; the query Q is then executed on D', hence avoiding to allocate and process nodes that will never be reached by Q. In this article, we propose a new approach, based on types, that greatly improves current solutions. Besides providing comparable or greater precision and far lesser pruning overhead, our solution—unlike current approaches—takes into account backward axes, predicates, and can be applied to multiple queries rather than just to single ones. A side contribution is a new type system for XPath able to handle backward axes. The soundness of our approach is formally proved. Furthermore, we prove that the approach is also complete (i.e., yields the best possible type-driven pruning) for a relevant class of queries and Schemas. We further validate our approach using the XMark and XPathMark benchmarks and show that pruning not only improves the main memory query engine's performances (as expected) but also those of state of the art native XML databases.
Electroconvulsive Therapy Training in Canada: A Call for Greater Regulation

Objective: A national survey of senior psychiatric residents' experience of electroconvulsive therapy (ECT) training was undertaken in Canada in 1989. Since then, guidelines have been published in Canada and the US with respect to ECT training in psychiatry residency programs. This study examines whether there has been any change in the Canadian resident ECT training experience through a second national survey. Methods: Confidential questionnaires assessing the training in and the attitudes toward ECT were sent to all 133 psychiatric residents in their final year of training in Canadian medical schools. Results: We attained a response rate of 68.3%. Of respondents, 88% felt that theoretical and practical ECT training should be a mandatory component of psychiatric residency programs. No marked improvements have occurred with respect to didactic and bedside training in ECT, compared with the original 1989 study. Only 18% of respondents reported that they feel completely competent administering ECT. Despite this, 59.3% anticipate working in an inpatient setting. Conclusions: The publication of training guidelines has made little impact on training in and attitudes toward ECT in senior psychiatric residents in Canada. Despite senior residents' acknowledgement of ECT's value, few feel competent to administer ECT after completing their training.
The Longitudinal Axis Rotation of the Apical Vertebra, the Vertebral, Spinal, and Rib Cage Deformity in Idiopathic Scoliosis Studied by Computer Tomography

The correlation between the lateral curve, the location and the length of the curve, and the longitudinal axis rotation of the apical vertebra has been studied in 65 patients with idiopathic scoliosis using computer-assisted tomography. This method provides the opportunity to describe the relationship between the rib hump, the longitudinal axis rotation, the lateral curve, and the kyphosis-lordosis with exceedingly small radiation doses. The vertebral rotation was found to be correlated to the lateral curve but not to the location or the length of the curve. The longitudinal axis rotation of the vertebrae is the most important factor for the development of the rib hump which is further accentuated by increased lordosis.
High-spatial resolution SED of NGC 1068 from near-IR to radio - Disentangling the thermal and non-thermal contributions

We investigate the idea that a sizable fraction of the interferometrically unresolved infrared emission of the nucleus of NGC 1068 might originate from processes other than thermal dust emission from the torus. We examine the contribution of free-free or synchrotron emission to the central mid- and near-IR parsec-scale emitting region of NGC 1068. Each mechanism is constrained using parsec scale radio data available for NGC 1068 in the 10 9 −10 11 Hz regime, and compared with the highest-resolution interferometric data available in the mid-infrared. It is shown that the unresolved emission in the interferometric observation (<1 pc) is still dominated by dust emission and not by contributions from synchrotron or free-free emission. As previous studies suggest, the interferometric observations appear to infer a clumpy structure of the dust distribution. Extrapolation of the radio free-free or synchrotron emission to the IR indicates that their contribution is <20% even for the unresolved fraction of the interferometric flux. The slope of the available radio data is consistent with a power law exponent α = 0.29 ± 0.07 that we interpret in terms of either free-free emission or synchrotron radiation from quasi-monochromatic electrons. We apply emission models for both mechanisms to obtain physical parameters. Furthermore, we attempt to quantify the possible contribution of the accretion disk to the near-infrared emission. It has been suggested, that the unresolved K-band flux in VLTI/VINCI interferometric observation at 46 m baseline (40% of the total K-band flux) might originate in the accretion disk. By using an accretion disk spectrum that has been adjusted to the luminosity and black hole mass of NGC 1068, we find that the expected accretion-disk flux in the K-band is negligible. Moreover, the scenario of detecting the accretion disk through holes in a clumpy torus is extremely unlikely. We conclude that all current IR data of NGC 1068 trace the torus dust emission, favoring a clumpy torus.
A Bayesian method for analysing spotted microarray data

In the decade since their invention, spotted microarrays have been undergoing technical advances that have increased the utility, scope and precision of their ability to measure gene expression. At the same time, more researchers are taking advantage of the fundamentally quantitative nature of these tools with refined experimental designs and sophisticated statistical analyses. These new approaches utilise the power of microarrays to estimate differences in gene expression levels, rather than just categorising genes as up- or down-regulated, and allow the comparison of expression data across multiple samples. In this review, some of the technical aspects of spotted microarrays that can affect statistical inference are highlighted, and a discussion is provided of how several methods for estimating gene expression level across multiple samples deal with these challenges. The focus is on a Bayesian analysis method, BAGEL, which is easy to implement and produces easily interpreted results.
Record 2.8mΩ-cm2 1.9kV enhancement-mode SiC VJFETs

Twenty amp normally-off enhancement mode 4H-SiC VJFETs are demonstrated with 1.9kV avalanche breakdown voltage and a specific on-resistance of 2. 8mΩ-cm2. The VJFETs shown near ideal subthreshold characteristics and maintain enhancement mode functionality to temperatures exceeding 175°C due to the optimized channel design with low DIBL characteristics. The low specific on-resistance enables the VJFET to have low intrinsic capacitances that result in low total switching times of less than 150ns at 15A at a Tj=175°C, and low total switching energies of 97µJ when switching 12A at Tj=25°C. Short circuit performance was also investigated with the VJFET exhibiting a rugged short circuit withstand capability in excess of 700µs at a VDS=600V.
Explicit evaluation of short circuit power dissipation for CMOS logic structures

For supply voltage standards such as Vdd > V TN + |V TP | short-circuit power dissipation significantly contributes to the total power dissipation in ICs. We propose a new alternative for the estimation of the short-circuit power dissipation, Psc, in CMOS structures. A first order calculation results in an explicit formulation for Psc, which clearly shows up the design and load parameters. Validations are performed on different configurations of inverters by comparison with HSPICE simulations. Discussions on the relative importance of short-circuit and dynamic power dissipation is given, together with considerations allowing an easy extension to gates.
Toward autonomic computing with DB2 universal database

As the cost of both hardware and software falls due to technological advancements and economies of scale, the cost of ownership for database applications is increasingly dominated by the cost of people to manage them. Databases are growing rapidly in scale and complexity, while skilled database administrators (DBAs) are becoming rarer and more expensive. This paper describes the self-managing or autonomic technology in IBM's DB2 Universal Database® for UNIX and Windows to illustrate how self-managing technology can reduce complexity, helping to reduce the total cost of ownership (TCO) of DBMSs and improve system performance.
Pubertal alterations in growth and body composition. V. Energy expenditure, adiposity, and fat distribution.

We determined whether activity energy expenditure (AEE, from doubly labeled water and indirect calorimetry) or physical activity [7-day physical activity recall (PAR)] was more related to adiposity and the validity of PAR estimated total energy expenditure (TEE(PAR)) in prepubertal and pubertal boys (n = 14 and 15) and girls (n = 13 and 18). AEE, but not physical activity hours, was inversely related to fat mass (FM) after accounting for the fat-free mass, maturation, and age (partial r = -0.35, P < or = 0.01). From forward stepwise regression, pubertal maturation, AEE, and gender predicted FM (r(2) = 0.36). Abdominal visceral fat and subcutaneous fat were not related to AEE or activity hours after partial correlation with FM, maturation, and age. When assuming one metabolic equivalent (MET) equals 1 kcal. kg body wt(-1). h(-1), TEE(PAR) underestimated TEE from doubly labeled water (TEE bias) by 555 kcal/day +/- 2 SD limits of agreement of 913 kcal/day. The measured basal metabolic rate (BMR) was >1 kcal. kg body wt(-1). h(-1) and remained so until 16 yr of age. TEE bias was reduced when setting 1 MET equal to the measured (bias = 60 +/- 51 kcal/day) or predicted (bias = 53 +/- 50 kcal/day) BMR but was not consistent for an individual child (+/- 2 SD limits of agreement of 784 and 764 kcal/day, respectively) or across all maturation groups. After BMR was corrected, TEE bias remained greatest in the prepubertal girls. In conclusion, in children and adolescents, FM is more strongly related to AEE than activity time, and AEE, pubertal maturation, and gender explain 36% of the variance in FM. PAR should not be used to determine TEE of individual children and adolescents in a research setting but may have utility in large population-based pediatric studies, if an appropriate MET value is used to convert physical activity data to TEE data.
Safety, tolerability, and biomarkers of the treatment of mice with aerosolized Toll-like receptor ligands

We have previously discovered a synergistically therapeutic combination of two Toll-like receptor ligands, an oligodeoxynucleotide (ODN) and Pam2CSK4. Aerosolization of these ligands stimulates innate immunity within the lungs to prevent pneumonia from bacterial and viral pathogens. Here we examined the safety and tolerability of this treatment in mice, and characterized the expression of biomarkers of innate immune activation. We found that neutrophils appeared in lung lavage fluid 4 h after treatment, reached a peak at 48 h, and resolved by 7 days. The peak of neutrophil influx was accompanied by a small increase in lung permeability. Despite the abundance of neutrophils in lung lavage fluid, only rare neutrophils were visible histopathologically in the interstitium surrounding bronchi and veins and none were visible in alveolar airspaces. The cytokines interleukin 6 (IL-6), tumour necrosis factor, and Chemokine (C-X-C motif) ligand 2 rose several hundred-fold in lung lavage fluid 4 h after treatment in a dose-dependent and synergistic manner, providing useful biomarkers of lung activation. IL-6 rose fivefold in serum with delayed kinetics compared to its rise in lavage fluid, and might serve as a systemic biomarker of immune activation of the lungs. The dose–response relationship of lavage fluid cytokines was preserved in mice that underwent myeloablative treatment with cytosine arabinoside to model the treatment of hematologic malignancy. There were no overt signs of distress in mice treated with ODN/Pam2CSK4 in doses up to eightfold the therapeutic dose, and no changes in temperature, respiratory rate, or behavioral signs of sickness including sugar water preference, food disappearance, cage exploration or social interaction, though there was a small degree of transient weight loss. We conclude that treatment with aerosolized ODN/Pam2CSK4 is well tolerated in mice, and that innate immune activation of the lungs can be monitored by the measurement of inflammatory cytokines in lung lavage fluid and serum.