Miracle-dz/UniFAR-FTUs huggingface dataset:
A Novel Model of one-class Bearing Fault Detection using RNCS Algorithm based on HOS

A novel model of bearing fault detection based on improved real-valued negative clone selection algorithm (RNCS) is presented In this paper. In many bearing fault detection application, only positive (normal) samples are available for training purposes, Then RNCS is used to generate probabilistically a set of fault detectors that can detect any abnormalities(including faults and damages) in the behavior pattern of bearings. Faults occurring in machine elements are often related to non-linear effects which may lead to non-linearity in the machine vibration signature. HOS make it possible to analyze the structure of the output signal and to provide information related to the non-linearity within the system. The extracted HOS features matrix from original signals are transformed to SVD features which are used as inputs to RNCS for one-class (normal) recognition to address the problem of difficultly collecting abnormal samples in bearing fault detection. Comparison of the performance of detection of RNCS with different detector's numbers is experimented. This proposed approach is compared against other MTP detection techniques. The results show the relative effectiveness of the proposed classifiers in detection of the bearing condition with some concluding remarks.
Attenuation of hyperoxic lung injury in rabbits with superoxide dismutase: effects on inflammatory mediators

Background. Superoxide dismutase (SOD) has been shown to attenuate hyperoxic lung injury. This effect is thought to be exhibited by scavenging superoxide released from neutrophils and other aerobic cells. The aim of the current study was to investigate the effect of pre‐treatment with SOD on the chemical mediators in hyperoxic lung injury.
Solid Lipid Nanoparticles Loaded with Edaravone for Inner Ear Protection After Noise Exposure

Background: Antioxidants and the duration of treatment after noise exposure on hearing recovery are important. We investigated the protective effects of an antioxidant substance, edaravone, and its slow-release dosage form, edaravone solid lipid nanoparticles (SLNs), in steady noise-exposed guinea pigs. Methods: SLNs loaded with edaravone were produced by an ultrasound technique. Edaravone solution or edaravone SLNs were administered by intratympanic or intravenous injection after the 1st day of noise exposure. Guinea pigs were exposed to 110 dB sound pressure level (SPL) noise, centered at 0.25–4.0 kHz, for 4 days at 2 h/d. After noise exposure, the guinea pigs underwent auditory brainstem response (ABR) threshold measurements, reactive oxygen species (ROS) were detected in their cochleas with electron spin resonance (ESR), and outer hair cells (OHCs) were counted with silvernitrate (AgNO3) staining at 1, 4, and 6 days. Results: The ultrasound technique was able to prepare adequate edaravone SLNs with a mean particle size of 93.6 nm and entrapment efficiency of 76.7%. Acoustic stress-induced ROS formation and edaravone exerted a protective effect on the cochlea. Comparisons of hearing thresholds and ROS changes in different animal groups showed that the threshold shift and ROS generation were significantly lower in treated animals than in those without treatment, especially in the edaravone SLN intratympanic injection group. Conclusions: Edaravone SLNs show noticeable slow-release effects and have certain protective effects against noise-induced hearing loss (NIHL).
Lower education and living in countries with lower wealth are associated with higher disease activity in rheumatoid arthritis: results from the multinational COMORA study

Objectives To investigate the relationship of socioeconomic status (SES) on an individual and country level with disease activity in rheumatoid arthritis (RA) and explore the mediating role of uptake of costly biological disease-modifying antirheumatic drugs (bDMARDs) in this relationship. Methods Data from a cross-sectional multinational study (COMOrbidities in RA) were used. Contribution of individual socioeconomic factors and country of residence to disease activity score with 28-joint assessment (DAS28) was explored in regression models, adjusting for relevant clinical confounders. Next, country of residence was replaced by gross domestic product (GDP) (low vs high) to investigate the contribution of SES by comparing R2 (model fit). The mediating role of uptake of bDMARDs in the relationship between education or GDP and DAS28 was explored by testing indirect effects. Results In total, 3920 patients with RA were included (mean age 56 (SD 13) years, 82% women, mean DAS28 3.7 (1.6)). After adjustment, women (vs men) and low-educated (vs university) patients had 0.35 higher DAS28. Adjusted country differences in DAS28, compared with the Netherlands (lowest DAS28), varied from +0.2 (France) to +2.4 (Egypt). Patients from low GDP countries had 0.98 higher DAS28. No interactions between individual-level and country-level variables were observed. A small mediation effect of uptake of bDMARDs in the relationship between education and DAS28 (7.7%) and between GDP and DAS28 (6.7%) was observed. Conclusions Female gender and lower individual or country SES were independently associated with DAS28, but did not reinforce each other. The association between lower individual SES (education) or lower country welfare (GDP) with higher DAS28 was partially mediated by uptake of bDMARDs.
Élasticité de la demande d'autoroutes à péage au Mexique = : Demand elasticity for Mexican toll roads

The objective of this study is twofold. First, to provide price demand elasticity estimates for each road segment of Mexico's largest tolled motorway network. Second, to establish which factors can explain the variation of these estimates. Unawareness about the users' sensitivity to toll variations can lead to crucial mistakes as has already happened during Mexico's first road concession program. We estimate toll elasticities for each road segment using a panel data regression approach. Our results show that on average Mexican toll road users are more sensitive to tariff variations than usually expected. Furthermore, the absolute value of the short term elasticity decreases with the toll road segment length and with the freeway's proportion of heavy traffic. This could indicate that toll road users become less sensitive to tariff changes as time savings increase with the distance and as the freeway conditions are deteriorated by freight trucks. A mi familia, quien siempre me ha apoyado À ma famille, qui m'a toujours soutenu To my family, who always support me
Validity of family history data on PD

Objective: To study the validity of information provided by case and control subjects (or their proxies) about PD among their first-degree relatives. Methods: Secondary cases of PD were assessed both through a single informant (family history method) and through the study of each relative (family study method). The family study method was considered as the standard for comparison, and the sensitivity and specificity of the family history method were studied. Results: A total of 133 population-based case subjects and their 655 relatives were recruited, and 119 population-based control subjects and their 511 relatives. Sensitivity was 68% (95% CI = 47 to 85) for cases and 45% (95% CI = 17 to 77) for controls. Specificity was 99% (95% CI = 98 to 99) for cases and 100% (95% CI = 99 to 100) for controls. The odds ratio (OR) for family history of PD was 4.34 (95% CI = 1.63 to 11.58, p = 0.003) using the family history method and 1.86 (95% CI = 0.78 to 4.44, p = 0.16) using the family study method. The former significant OR more than doubled the latter not significant OR (relative bias = 133%). Bias was more pronounced for proxy interviews and for women informants, and when the relatives were siblings, were living, and were examined or had medical record documentation. Conclusions: Case subjects with PD (or their proxies) are more aware of PD among their first-degree relatives than control subjects (or their proxies); however, they overreport PD in relatives who are not affected. This causes a substantial family information bias.
Rethinking the Social Welfare Regime Model: The Case of Public Policy Toward Israeli Philanthropists

Following a study on the changing relations between government and philanthropy in Israel, this study highlights the need to rethink the typology of social welfare regimes proposed by Anheier and Daly (2007). The findings of our study indicate that there has been a rapprochement between government and philanthropy in Israel. This trend has led to formal dialogue and collaborations. This trend has also promoted the development of policies toward philanthropy in various government ministries and agencies. The development and implementation of these policies have been facilitated by changes in the unique contextual factors of Israel’s welfare regime. Based on the findings, we propose a conceptualization for understanding governmental policies toward philanthropy in shifting welfare regimes. With regard to the theoretical and practical implications of the study, we propose a model for hybrid welfare regimes that are experiencing ongoing changes.
Cutting Edge: Ectopic Expression of CD40 Ligand on B Cells Induces Lupus-Like Autoimmune Disease1

CD40 ligand (CD40L) is ectopically expressed on B cells in patients with systemic lupus erythematosus (SLE) and lupus-prone BXSB mice. To assess the role of the ectopic CD40L expression in development of SLE, we have established transgenic mice expressing CD40L on B cells. Some of the 12- to 14-mo-old CD40L-transgenic mice spontaneously produced autoantibodies such as antinuclear Abs, anti-DNA Abs, and antihistone Abs. Moreover, approximately half of the transgenic mice developed glomerulonephritis with immune-complex deposition, whereas the kidneys of the normal littermates showed either no pathological findings or only mild histological changes. These results indicate that CD40L on B cells causes lupus-like disease in the presence of yet unknown environmental factors that by themselves do not induce the disease. Thus, ectopic CD40L expression on B cells may play a crucial role in development of SLE.
The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold

The Epstein–Barr virus (EBV) nuclear antigen 1 (EBNA1) is one of the earliest viral proteins expressed after infection and is the only latent protein consistently expressed in viral-associated tumors. EBNA1's crucial role in viral DNA replication, episomal maintenance, and partitioning is well examined whereas its importance for the immortalization process and the tumorgenicity of EBV is unclear. To address these open questions, we generated, based on the maxi-EBV system, an EBNA1-deficient EBV mutant and used this strain to infect primary human B cells. Surprisingly, lymphoblastoid cell lines (LCL) emerged from these experiments, although with very low frequency. These cell lines were indistinguishable from normal LCLs with respect to proliferation and growth conditions. A detailed analysis indicated that the entire viral DNA was integrated into the cellular genome. At least 5 of the 11 latent EBV proteins were expressed, indicating the integrity of the EBV genome. EBNA1-positive and ΔEBNA1-EBV-LCLs were injected into severe combined immunodeficient (SCID) mice to examine their tumorgenicity in comparison. Both groups supported tumor growth, indicating that EBNA1 is not mandatory for EBV's oncogenic potential. The results shown provide genetic evidence that EBNA1 is not essential to establish LCLs but promotes the efficiency of this process significantly.
Injecting risk behaviour and related harm among men who use performance- and image-enhancing drugs.

INTRODUCTION AND AIMS Performance- and image-enhancing drugs have the potential to be a significant public health issue. Detailed data on PIEDs injection are difficult to obtain because of the illicit and unsupervised way in which many PIEDs are used, and the hidden nature of the group. Our study examines the patterns of use, risk behaviours and related harm associated with PIEDs injection. We also report the ways in which PIEDs users currently seek injecting equipment and harm-reduction advice. DESIGN AND METHOD Data were obtained via a structured questionnaire administered in face-to-face interviews with 60 men who used PIEDs (primarily anabolic androgenic steroids) for non-medical purposes. RESULTS Although the rates of needle sharing were low (5%), the men more frequently reported re-use of needles/equipment, injecting from a shared container (bladders, vials, etc.), injecting other illicit drugs, injecting insulin and targeting small muscle groups. Self-reports of being hepatitis C antibody positive were associated with lifetime use of heroin and injection of other illicit drugs. All HIV positive participants were gay/bisexual men. Participants reported a range of other injection-related injuries and diseases such as fevers, scarring and abscesses. 'Risky' injectors (38% of participants) were more likely to initiate PIEDs use at a younger age, use PIEDs in a larger number of cycles per year and report involvement in a violent/aggressive incident than 'low risk' injectors and report involvement in a violent/aggressive incident than 'low risk' injectors. Participants mainly reported seeking information about PIEDs from internet sites (62%) and friends (55%). CONCLUSIONS An over-reliance on personal networks and internet forums limits this groups' access to objective harm reduction advice and primary care services. Targeted, PIEDs-specific interventions are needed.
Diaquabis(2,2′-bi-1H-imidazole-κ2 N 3,N 3′)nickel(II) bis(3-methylbenzoate) 3-methylbenzoic acid disolvate

In the title compound, [Ni(C6H6N4)2(H2O)2](C8H7O2)2·2C8H8O2, the NiII atom (site symmetry ) is coordinated by two N,N′-bidentate 2,2′-biimidazole ligands and two water molecules, resulting in a slightly distorted trans-NiO2N4 geometry for the metal ion. In the crystal, the components are linked by N—H⋯O and O—H⋯O hydrogen bonds, generating an infinite two-dimensional network running parallel to (100). The methyl group of the benzoic acid molecule is disordered over two sites in a 0.563 (17):0.437 (17) ratio.
Flux-Balancing Scheme for PD-Modulated Parallel-Interleaved Inverters

A simple scheme to realize phase-disposition carrier pulse width modulation (PD PWM) for parallel two-level voltage-source converters (2L-VSCs) is presented in this paper. The proposed implementation only uses a single carrier signal and can easily be implemented using a digital signal processor. The operation of the parallel VSCs with the coupled inductor (CI) under the PD PWM is briefly discussed, and the associated dc flux injection problem is investigated. A CI saturation issue during the band transition under the PD PWM scheme is also explored, and the strategy to avoid this problem is presented. In addition, the proposed strategy also maintains a volt–second balance to synthesize desired reference space voltage vector during the band transition. As a result, a smooth transition from one modulation band to the other is ensured without causing disturbances in the line-to-line voltage. The switching losses and the harmonic performance of the proposed implementation are also compared with the commonly used phase-shifted carrier pulse width modulation. The implementation issues are discussed and the experimental results are also presented.
Social Anxiety and Sociometric Nomination in Spanish Students of Compulsory Secondary Education

Abstract Adolescents with social anxiety can manifest great interference in their relationship with classmates and other peers, as well as in their school performance. The aim of this study was to analyze the sociometric nominations and assessment of students with high social anxiety by their peers and teachers, and to determine whether these assessments differ significantly between evaluators (peers vs. teachers), in a sample of 2022 (51.1% male) Spanish adolescents aged between 12 and 16 years. Social anxiety was assessed using the Social Phobia and Anxiety Inventory questionnaire. Sociometric identification and assessment of various educational aspects of the students was performed through the Socio program and Teacher assessment scales, respectively. Results show that students with high social anxiety were nominated by peers as popular, rejected and neglected with the same frequency and proportionately less nominated as leaders, friendly, cooperative, and quarrelsome students than those without high social anxiety (d < .25). Teachers assessed the sociometric status of a student with low social anxiety in the same way as that of students with high social anxiety, although they considered the latter as less impulsive, less conflictive, less passive and more compliant with rules (d > .97). Finally, peers significantly nominated students with high social anxiety more as leaders, cooperative, quarrelsome, obedient and good students than their teachers (d < .42). In conclusion, this study shows that adolescents with high social anxiety are valued and nominated by their peers and teachers differently.
Hyporesponsiveness of Donor Cells to Lipopolysaccharide Stimulation Reduces the Severity of Experimental Idiopathic Pneumonia Syndrome: Potential Role for a Gut-Lung Axis of Inflammation1

Idiopathic pneumonia syndrome (IPS) is a major complication of allogeneic bone marrow transplantation (BMT). We have shown that experimental IPS is associated with increased levels of LPS and TNF-α in the bronchoalveolar lavage (BAL) fluid. We hypothesized that the deleterious effects of these inflammatory mediators in the lung may be linked to gut injury that develops after BMT. To test this hypothesis, we used mouse strains that differ in their sensitivity to LPS as donors in an experimental BMT model. Lethally irradiated C3FeB6F1 hosts received BMT from either LPS-sensitive or LPS-resistant donors. Five weeks after BMT, LPS-resistant BMT recipients had significantly less lung injury compared with recipients of LPS-sensitive BMT. This effect was associated with reductions in TNF-α secretion (both in vitro and in vivo), BAL fluid LPS levels, and intestinal injury. The relationship between TNF-α, gut toxicity, and lung injury was examined further by direct cytokine blockade in vivo; systemic neutralization of TNF-α resulted in a significant reduction in gut histopathology, BAL fluid LPS levels, and pulmonary dysfunction compared with control-treated animals. We conclude that donor resistance to endotoxin reduces IPS in this model by decreasing the translocation of LPS across the intestinal border and systemic and pulmonary TNF-α production. These data demonstrate a potential etiologic link between gut and lung damage after BMT and suggest that methods that reduce inflammatory responses to LPS, and specifically, those that protect the integrity of the gut mucosa, may be effective in reducing IPS after BMT.
Music Mood Wheel: Improving Browsing Experience on Digital Content through an Audio Interface

Mobile devices for listening to digital music can now contain a huge number of musical titles. Search for appropriate music content becomes difficult and time-consuming. The interfaces on MP3 CD players or flash MP3 players available on the market usually combine buttons, jog-wheels and small displays of one to three lines. The most common approach to music browsing is still either one-step forward and backward movement with two buttons, or moving inside a tree of options. In our approach, we shift from the "tree of options" paradigm to a "search by ear" browsing experience. Following the construction of a first rough prototype we found that our interface performed well in an experiment with 40 participants, on a collection of 3500 songs. Ongoing and future works cover the development of an advanced pro to type on a smartphone running the Windows mobile operating system and a new experiment in similar conditions
Reduced insulin secretion: an independent predictor of body weight gain.

A causal role in the pathogenesis of obesity has been proposed for hyperinsulinemia and insulin resistance in populations with a high prevalence of a "thrifty genotype. " An alternative hypothesis is that obesity-induced hyperinsulinemia is an adaptation which, by increasing central nervous system insulin signaling (which suppresses food intake), confers resistance to weight gain. To characterize the relationship between the level of insulin secretion and the risk of weight gain, we examined whether any of three different measures of the level of insulin secretion (the area under the plasma insulin curve during both a meal tolerance test and an oral glucose tolerance test, and the acute insulin secretory response to iv glucose) was predictive of weight gain in a prospective study of 97 Pima Indians (64 males and 33 females) with normal glucose tolerance. During a mean (+/- SD) follow-up period of more than 3 yr (males, 3.58 +/- 1.46 yr; females, 3.02 +/- 1.73 yr), average weight increased 2.1 +/- 3.0%/yr in males and 3.5 +/- 3.6%/yr in females, reflecting a mean annual increase in body fat content of 6.9%/yr in both sexes. Insulin secretion was negatively associated with the rate of weight gain, whether assessed by the insulin response during the meal tolerance test (r = -0.35; P < 0.001), the oral glucose tolerance test (r = -0.30; P = 0.004), or the acute insulin secretory response to iv glucose (r = -0.28; P = 0.002). Moreover, the significance of the relationship between each measure of insulin secretion and weight gain persisted after controlling for differences in age, sex, initial body weight, and insulin sensitivity. Relatively reduced insulin secretion, therefore, is a significant and independent predictor of the tendency to gain weight and adiposity in Pima Indians. The presence of relative insulin resistance also conferred an independent reduction in the risk of weight gain in some regression analyses. We conclude that insulin resistance and hyperinsulinemia are unlikely to play a causal role in the development of obesity, and that relatively reduced insulin secretion is a marker of an increased risk of weight gain in this population. These conclusions support the hypothesis that the level of insulin secretion plays an important role in long term body weight regulation.
A munkahelyi egészségprogramok értékteremtésének mérési lehetőségei

A fluktuacio, a hianyzas es a kimerulten valo munkavegzes sok kart okoz a cegeknek. E vesztesegek csokkentesenek egyik lehetseges eszkoze a vallalati egeszsegprogram műkodtetese. Az ilyen kezdemenyezesek nepszerűseget mutatja, hogy mig 2008-ban globalisan a multinacionalis vallalatok 34 szazaleka inditott ilyen programokat, 2014-ben mar 56, 2016-ban pedig 69 szazalekuk. De mennyire sikeresek ezek a programok? Hogyan merhető az altaluk teremtett ertek? E cikk nemzetkozi irodalomkutatasra epitve az egeszsegprogramok hatasainak meresi lehetősegeit tekinti at. Ez alapjan a hatekonysagot harom kulonboző szemleletben szoktak megkozeliteni. A penzben jol merhető vallalati előnyokre fokuszalo ROI-szemlelet mellett mind elterjedtebb a programok dolgozokra gyakorolt hatasat merő VOI-megkozelites. Ugyanakkor makroszinten a tarsadalmi hatasokat is lefedő, de csak penzben merő SROI-modszertan hasznalata lehet a celravezető.