Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognosis and Outcome of Non-Hodgkin Lymphoma in Primary Sjögren Syndrome

AbstractSjögren syndrome (SS) has been associated with the development of non-Hodgkin lymphoma (NHL). From a cohort of 584 SS patients followed in our department from 1980 to 2010, we retrospectively analyzed 53 consecutive NHL cases. Considerations included histologic type, clinical manifestation and NHL staging, treatment, response rate and overall survival (OS), event-free survival (EFS), and standardized mortality ratio (SMR). Mucosa-associated lymphoid tissue (MALT) lymphomas constituted the majority (59%) of NHL subtypes, followed by nodal marginal zone lymphomas (NMZLs) (15%) and diffuse large B-cell lymphomas (DLBCLs) (15%). Six lymphoma patients died during the median follow-up of 40.8 months. The corresponding age/sex-adjusted SMR of SS with and without NHLs versus the general population was 3.25 (95% confidence interval [CI] 1.32–6.76) and 1.08 (95% CI, 0.79–1.45), respectively. A “watch and wait” policy was adopted for 9 patients with asymptomatic localized salivary MALT lymphomas. Eight patients with limited-stage MALT lymphomas and extraglandular manifestations were treated with rituximab. Ten MALT lymphoma patients with disseminated disease received chemotherapy with or without rituximab. The 3-year OS and EFS in patients with MALT lymphomas was 97% and 78%, respectively. Rituximab plus CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) was the chosen therapeutic intervention for patients with DLBCLs. A successful outcome was recorded for this group, with 100% OS and EFS at 3 years. Patients with NMZLs had a less favorable outcome, with a 3-year OS of 80% and EFS of 53%. Our results describe the course and prognosis of SS-associated NHL and highlight the need for a risk-stratified treatment approach.
Stiffness Characteristics of Joshi ’ s External Stabilization System under Axial Compression : a Finite Element Method Based Study

A finite element model of fractured tibia with Joshi’s External Stabilizing System (JESS) mounted on it was developed using 3D beam elements in the ANSYS software. The model was loaded in axial compression and the average axial stiffness of the model was calculated. The analytical value of axial stiffness was compared with reported experimental value to validate the finite element model. The validated model was used to carry out parametric studies on the model to determine the axial properties of JESS. It was observed that axial stiffness of JESS increased by 58% when k-wire diameter was varied from 2 mm to 4 mm while keeping other geometric configurations of the device constant; however, the axial stiffness of the device does not show any significant improvement when the diameter of medio-lateral pins in diaphyseal hold were increased. The findings should help in understanding the axial properties of JESS so that it can be used judiciously in clinical applications.
Stability and change in children with Developmental Coordination Disorder.

BACKGROUND Children with Developmental Coordination Disorder (DCD) are a heterogeneous group who have a marked impairment in the performance of functional motor skills. Provision for these children is usually made via a paediatrician through occupational or physiotherapy; though with a prevalence rate of 5%, regular provision is rarely possible because of limited professional resources. METHODS This study covers a period of nearly 4 years and initially examined a group of 31 children first identified as having DCD at 7-9 years of age. The children were observed and assessed before, during and after a total of 16 weeks of intervention carried out by parents and teachers. This was followed by a period of monitoring of performance for 26 of the children in the motor domain plus other abilities such as educational progress and self-concept. Individual children were tracked using a variety of qualitative and quantitative approaches, building up longitudinal whole child profiles. RESULTS Following intervention, 14 of the 26 children have shown improvement and stability in all areas and no longer display DCD symptoms. Eight children have profiles which have shown variability, with the children moving in and out of the DCD classification, while the remaining four children have consistently scored poorly in their movement skills and in addition received ongoing support in school for academic subjects. CONCLUSIONS The study has confirmed that children with DCD show varying profiles over a period of time and that the profiles have distinct characteristics related to events in the child's life. This approach to examining stability and change in the progressions of children's difficulties is in keeping with an ecological approach to explaining development with its multilayered influences creating changes.
Genetic Testing in Pheochromocytoma‐ and Paraganglioma‐Associated Syndromes

Abstract: Genetic understanding of pheochromocytoma (PHEO) and paraganglioma (PGL) syndromes has recently expanded with the identification of the involvement of the mitochondrial complex II peptides, namely the succinate dehydrogenase subunit B (SDHB), subunit C (SDHC), and subunit D (SDHD). In patients with PHEO and/or PGL genetic testing for germline mutations in SDHD and SDHB has been recommended, in addition to the PHEO susceptibility genes VHL and RET. After careful clinical assessment of the patient, suspected familial disease may direct the clinician to the appropriate gene for testing. In the absence of obvious features of familial disease, the decision regarding the appropriate gene for testing is more difficult. Such testing can be costly and time consuming, but a rational prioritization of gene testing can streamline the process. Therefore in order to achieve this for apparently sporadic cases we propose a decision matrix based on site of tumor, functionality, and age at presentation.
Rates of sediment recycling beneath the Acapulco trench: Constraints from (U-Th)/He thermochronology

[1] The Sierra Madre del Sur mountain range is an uplifted forearc associated with the subduction of the Cocos plate along the Acapulco trench beneath mainland southern Mexico. The shallow subduction angle, the truncation of geologic features along the modern Acapulco trench, and direct seismic and drill hole observations in the trench through deep sea drilling data suggest that subduction erosion is an important process during the evolution of this margin. Turbidites derived from the uplifted forearc are the predominant sedimentary input into this trench, while pelagic sediments are subordinate. Apatite (U-Th)/He ages were obtained on 23 samples from two transects across the Sierra Madre del Sur (Acapulco and Puerto Escondido) and reveal slow cooling during the Miocene. (U-Th)/He ages range between ∼25 and 8 Ma and correlate inversely with elevation. Long-term erosional exhumation rates inferred from these ages range from 0.11 to 0.33 km/m.y. , with higher rates in the range core, and suggest that the Sierra Madre del Sur has been a slowly decaying mountain range, since at least the early Miocene. Apparent Miocene-Pliocene sedimentation (“preservation”) rates in the Acapulco trench derived from Deep Sea Drilling Project data are about an order of magnitude smaller than the Miocene forearc erosion rates estimated from (U-Th)/He ages, suggesting that the terrigenous input to the trench was almost entirely recycled via subduction erosion, at least during the Miocene. The Miocene subducted flux per unit length of the margin is about 30 km3/(km m.y.), or a subducted volume per unit time of 44 × 103 km3/m.y. , when integrated over the length of the trench.
Research and Development Expenses under IFRS Mandatory Implementation: A Value Relevance Approach

The paper focuses on the degree to which the accounting treatment of R&D expenditure is stock price informative following the adoption of IAS. Therefore, using recent data of French listed companies, starting from the year in which IFRS were applied, 2005-2015, the present study examines the value relevance of the different R&D accounting treatments. Unlike evidence regarding the pre-IFRS period in France, we find that the capitalized portion of R&D is not correlated with market values, suggesting that under IFRS mandatory implementation, R&D assets are not value relevant. The expensed portion of R&D is positively related to market values only for manufacturing companies. Accordingly, we conclude that IFRS implementation has implications on the valuation of R&D expenditure by investors in French firms. DOI: 10.15458/85451.67
THE INFLUENCE OF COMPANY SIZE, MANAGERIAL SHARE OWNERSHIP,AND PROFITABILITY ON FIRM VALUE OF MANUFACTURING COMPANY LISTED ON BEI

The primary goal of the company is to maximize firm value. Firm value is investor perception of the company's success rate, it is often associated with stock prices. This research aims to examine the effect of company size ,insider ownership, and profitability, towards the value of the company.This research uses secondary data, of the manufacturing companies which listed on BEI with periods 2014-2016. Research sample of 39 manufacturing companies, where the method used is purposive sampling is a sampling method that takes an object with the specified criteria. Analysis of the data used to analyze the factors that affect firm value is multiple regression analysis. The results of this research finds three independents variable have a significant effect on firm value . Three independents variable have significantly effect on firm value in this research: (i) company size is that of positive significant, (ii) managerial share ownership is that positive significant, (iii) profitability is that positive significant. Keywords : firm value, managerial share ownership, profitability, and company size
Induction of protective immunity to Plasmodium falciparum in Saimiri sciureus monkeys with partially purified exoantigens

Soluble Plasmodium falciparum exoantigens in crude culture supernatant fluids induced protective immunity against experimental falciparum malaria in Bolivian Saimiri sciureus monkeys. Susceptible squirrel monkeys were vaccinated with an aluminum hydroxide-fortified fraction purified from culture supernatants of P. falciparum Indochina I and Geneve/SGE-1 by cation-exchange (sulfopropyl-trisacryl) chromatography. Animals immunized with sulfopropyl-purified and corresponding control immunogens were challenged with whole blood containing monkey-adapted virulent organisms of the Indochina I strain. Hematological, serological, and parasitological profiles, including the appearance of crisis forms, served as potential indicators of protection. This immunogen conferred significant clinical protection of squirrel monkeys against needle challenge with the homologous Indochina I strain and a moderate degree of heterologous strain immunity.
IBP-SVD: A practical method for learning adaptive dictionaries for image de-noising

In recent years, there is a growing interest in the research of sparse representations for signals over an overcomplete dictionary. The Dictionaries can be either pre-specified transforms or designed by learning from a set of training signals. The K-SVD is a dictionary training algorithm recently proposed. However, It can not find the truly sparse representations in sparse coding stage. We analyze the relationship between matching pursuit and basis pursuit algorithms and present another practical method, called IBP-SVD, which can find the sparsest representations frequently. It effectively improves the training speed and the precision of the trained dictionary. Experimental results of image de-noising show that IBP-SVD has a better performance than K-SVD method and reduces time in the process of learning dictionaries.
Helper T‐Cell Subsets: Phenotype, Function and the Role of Lymphokines in Regulating their Development

We have concentrated here on the lymphokines which might serve to regulate the different pathways of precursor development. We suggest that, as a result of antigenic stimulation, specific precursor cells both proliferate and become committed to develop into either an effector cell, a memory cell or an anergized cell. Anergy has not been dealt with in this review, but it is likely to be one of the options available. The development of an effector population takes 4-7 d (quite analogous to the time it takes for CTLp to become CTL and for resting B to become Ab-forming cells). The effector populations are large, generally IL-2R-positive cells. These cells have upregulated many adhesion molecule systems [e.g., Pgp-1, LFA-1 and ICAM-1 (Swain unpublished)], but downregulated the Mel-14 homing receptor. Effectors are ready to respond to APC such as specific B cells with a rapid synthesis and secretion of lymphokines. The effector population is then quickly downregulated, both by the turn off of lymphokine synthesis/secretion and possibly by its own suicide. This kind of pattern makes teleological sense since the cells making such high titers of lymphokines could have many potent pleitropic effects. It also seems to be the strategy employed in the generation of other terminally differentiated effectors (such as CTL and plasma cells). The requirement for restimulation and the requirement for direct and perhaps prolonged contact between the helper effector and the APC-B cell can be expected to help ensure that these lymphokines are localized (reviewed in Swain & Dutton 1987, Swain & Croft 1990) and effectively delivered to specific responding cells. We postulate that at the same time, or perhaps subsequent to this, another set of signals drives precursors to generate prememory cells. Our studies suggest these emerging memory cells may be phenotypically unique and we postulate that they are specialized to become a "long-lived" population of memory cells that will persist indefinitely as a protective population of increased frequency for the antigen encountered and which is also able to respond more rapidly and effectively. The greater effectiveness of the memory response would thus be due to dramatically increased frequency, to characteristic and stable changes in adhesion molecule expression and to the fact that, in addition to IL-2, resting memory cells also secrete at least low titers of IL-3, IL-4, IFN-gamma and other lymphokines upon initial restimulation. (ABSTRACT TRUNCATED AT 400 WORDS)
Mixing by shear instability at high Reynolds number

Shear instability is the dominant mechanism for converting fluid motion to mixing in the stratified ocean and atmosphere. The transition to turbulence has been well characterized in laboratory settings and numerical simulations at moderate Reynolds number—it involves “rolling up”, i.e., overturning of the density structure within the cores of the instabilities. In contrast, measurements in an energetic estuarine shear zone reveal that the mixing induced by shear instability at high Reynolds number does not primarily occur by overturning in the cores; rather it results from secondary shear instabilities within the zones of intensified shear separating the cores. This regime is not likely to be observed in the relatively low Reynolds number flows of the laboratory or in direct numerical simulations, but it is likely a common occurrence in the ocean and atmosphere.
Pulsed Electromagnetic Field Radiation From a Wide Slot Antenna With a Dielectric Layer

Analytic time-domain expressions are derived for the pulsed electromagnetic field radiated by a wide slot antenna with a dielectric layer in a two-dimensional model configuration. In any finite time window of observation, exact pulse shapes for the propagated, reflected and refracted wave constituents are constructed with the aid of the modified Cagniard method (the Cagniard-DeHoop method). Numerical results are presented for field pulse shapes at the dielectric/free-space interface, the pulse time widths of the excitation being chosen such that the separate arrivals from the two edges of the slot can be distinguished. Applications are found in any system whose operation is based on pulsed electromagnetic field transfer and where digital signals are detected and interpreted in dependence on their pulse shapes.
Band-Rejected Ultrawideband Planar Monopole Antenna With High Frequency Selectivity and Controllable Bandwidth Using Inductively Coupled Resonator Pairs

A novel band-rejected ultrawideband (UWB) planar monopole antenna is investigated. By utilizing the resonance nature of folded strips and a new inductive coupling scheme, the antenna demonstrates bandstop-filter-like response with high frequency selectivity and controllable bandwidth at the rejection band. The design methodology is introduced. The simulated and measured results including impedance matching, radiation patterns, and gain responses are investigated. An antenna equivalent circuit model with improved accuracy is discussed as well. When compared with our previous work, the new design demonstrates substantial improvements in many aspects. The argument will be discussed and verified carefully throughout the communication.
MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition

Multidrug resistance (MDR) translocators recently identified in bacteria constitute an excellent model system for studying the MDR phenomenon and its clinical relevance. Here we describe the identification and characterization of an unusual MDR gene (mdfA) from Escherichia coli. mdfA encodes a putative membrane protein (MdfA) of 410 amino acid residues which belongs to the major facilitator superfamily of transport proteins. Cells expressing MdfA from a multicopy plasmid are substantially more resistant to a diverse group of cationic or zwitterionic lipophilic compounds such as ethidium bromide, tetraphenylphosphonium, rhodamine, daunomycin, benzalkonium, rifampin, tetracycline, and puromycin. Surprisingly, however, MdfA also confers resistance to chemically unrelated, clinically important antibiotics such as chloramphenicol, erythromycin, and certain aminoglycosides and fluoroquinolones. Transport experiments with an E. coli strain lacking F1-F0 proton ATPase activity indicate that MdfA is a multidrug transporter that is driven by the proton electrochemical gradient.
Estimating Demand for Long-term Care Insurance in Thailand: Evidence from a Discrete Choice Experiment

At present, the Thai public health insurance schemes cover medical care. However, the financial risk associated with long-term care needs is unprotected. The increasing likelihood of Thai elderly living longer and living alone has raised great concern about their quality of life. In the wake of the declining informal support capacity, a public long-term care insurance (LTCI) system has been considered as a potential alternative. Because the public will have to contribute to the LTCI fund, this paper explores whether the Thai people are willing to pay for such a provision. The LTCI demand is estimated based on the stated preference survey data. Our results show that most respondents are willing to pay to insure against their risk associated with long-term care expenditure, but their preferences are very heterogeneous. Gains and losses for different policy scenarios, measured by consumer surplus, are discussed.
Decomposition of efficiency using DEA window analysis

Purpose The purpose of this paper is to examine empirically the efficiency types of Islamic and conventional banks. It seeks to show whether the efficiency level of conventional and Islamic banks significantly differs from each other. In addition, it investigates the influential factors on each type of efficiency. Design/methodology/approach The paper utilises the data envelopment analysis in its windows version to estimate the efficiency scores reflecting the time variance and compares between banking models. The paper uses pure technical efficiency (TE) and scale efficiency to achieve the objective of the study. In addition, the panel data technique is adopted to assess the determinants of the efficiency of the banks econometrically. Findings The findings of panel regression initially indicate that the pure TE is higher for conventional banks compared to Islamic banks. However, the Islamic banks are more scale efficient than their conventional counterpart. Macro and micro indicators have different impacts on the both types of efficiency. However, the unique factors that show consistent influence on the efficiency types were loans/finance, non-interest income/finance/liquidity and GDP. Furthermore, the determinants are shaped differently for Islamic and conventional banks when the banking model is controlled for. Originality/value This paper examines the efficiency types using a unique window analysis approach to examine the types of efficiency with a longitudinal set of data from 1996 to 2011.
Landmarks in Linguistic Thought Volume III: The Arabic Linguistic Tradition

The Early Islamic Grammatical TraditionLandmarks in Linguistic ThoughtBooks-in-Brief: Mapping Intellectual Building and the Construction of Thought and ReasonGreek elements in Arabic linguistic thinkingLe Deuxième SexePrinciples of Linguistic Change, Cognitive and Cultural FactorsNoam ChomskyLanguage and GestureLandmarks in Linguistic Thought Volume IIIThe Origins of MeaningThe Arabic LanguageThe Most Famous Landmarks of New York CityPhilosophy In The FleshLandmarks In Linguistic Thought Volume IThe Language-makersLandmarks in Linguistic Thought IIMapping Intellectual Building and the Construction of Thought and ReasonThe Explanation of Linguistic CausesLearner Contributions to Language LearningLandmarksTeaching and Researching Language Learning StrategiesLandmarks in Linguistic Thought 1Landmark Essays on ESL WritingEdinburgh History of the Book in Scotland, Volume 3: Ambition and Industry 1800-1880Through the Language GlassCognitive English GrammarLinguistic Relativity in SLALandmarks in Linguistic Thought IIIntroduction to Islamic Theology and LawMusic, Language, and the BrainSyntactic StructuresGlobish the World OverThe Language AnimalSocial Cognition and CommunicationHistory, Metaphors, FablesFoundations of Cognitive Grammar: Theoretical prerequisitesLandmarks in Linguistic Thought IIIThinking and Speaking in Two LanguagesLanguageThe Language Machine
Sentence boundary disambiguation for Indonesian language

Sentence boundary detection is essential for natural language processing (NLP). Sentence boundary detection in the Indonesian language has lots of problems, which includes punctuation, abbreviation, and character in the bracket. The disambiguation should be detected as sentence boundary. Thus the sentence boundary system can divide the sentences accurately. This study presents the development of a training dataset for the existing model to optimize supervised sentence boundary detection for the Indonesian language. Indonesian Translation of the Quran (ITQ) data set was used in this study by using the supervised method. The following is the process briefly: create the training data, apply sentence detection to separate sentences on ITQ, and calculate precision, recall, and F-measure. The result is quite promising, it gives as follows: Precision of 91.7%, Recall 81.6%, and F-Measure 86.4 %, respectively.
Method and the Agar Plate Method of Proportion . J . Comparison with the Radiometric BACTEC 460 TB to Four Major Antituberculous Drugs : tuberculosis MycobacteriumSystem for Testing Susceptibility of 2002 . Evaluation of Automated BACTEC MGIT 960

Clin. Microbiol. 40(2):607-610. Method and the Agar Plate Method of Proportion. J. Comparison with the Radiometric BACTEC 460TB to Four Major Antituberculous Drugs: tuberculosis Mycobacterium System for Testing Susceptibility of 2002. Evaluation of Automated BACTEC MGIT 960 et al. Enrico Tortoli, Marta Benedetti, Alessandra Fontanelli, Method of Proportion 460TB Method and the Agar Plate with the Radiometric BACTEC Comparison Antituberculous Drugs: to Four Major tuberculosis Mycobacterium Susceptibility of MGIT 960 System for Testing Evaluation of Automated BACTEC