Miracle-dz/UniFAR-FTUs huggingface dataset:
Multi-hop scheduling and local data link aggregation dependant Qos in modeling and simulation of power-aware wireless sensor networks

In this study of wireless sensor networks (WSN) protocols, the application Qos, system, and protocol performance metrics are measured for a large scalable wireless deployment using a typical wireless radio and an energy model. As there are many different types of WSN algorithms, we have categorized it into pro-active, re-active, and query driven information processing. A typical Qos is based on the useful lifetime of sensor nodes, after which reliability of the sensor data cannot be guaranteed and typically, a threshold such as a percentage of the sensor drains out of energy or a minimum through-put of real-time data from the sensor network is expected, which is used to compare the Qos of the routing algorithm. The results from lifetime based Qos, measured in simulation seconds, for the implemented protocols show that with varying sampled data sources for a BE Qos multi-hop deployment and varying percentage of cluster heads in a time- synchronized deployment, the lifetime is based on network size and protocol invariant. However, low sensing ranges result in dense networks, and therefore, it becomes necessary to achieve an efficient medium-access protocol subjected to power constraints. Scalability of sensor network applications are based on energy energy-harvesting techniques in which the various layers of the network inter-operate and extend the system network lifetime, the battery residual power per node, and the application reliability in terms of cross-layer energy savings. In this study, we have extended the lifetime metrics from a constant metrics into a break down of how much percentage of time is spent for Tx, Rx, and Idle tasks, respectively. This helps one to highlight the cross-layer energy dissipation per node and how the performance of an algorithm differs in terms of duty-cycling. Furthermore, we have shown that the energy savings due owing to the distributed algorithms in a large sensor network will not be practical without a complimentary lower-layer MAC. We show have demonstrated that the Qos is very much related to the ambient conditions, namely, are the Rx and Idle modes. From these preliminary results, we have added a new category of WSN protocols which are based ion the renewable energy resources, namely, the Fusion Ambient Renewable Measuring Sensors (FARMS). The study of sensor FARMS -harvesting applications allows one to measure the impact on Idle, Sleep, and renewable energy cycles as well as their unique deployment (density) needs, as all the sensor are not active(Rx) at all times. We have also shown that the efficiency of cross-layer Qos performance of routing algorithms with MAC losses has a long tail which is similarly observed in Power Law. In this sensor network model we like to show the complexity of clustering, messaging and data rate in terms of O(√(N) log N), O(N) and O(log2 N) where N is the number of nodes.
A 420µW, 4 GHz approximate zero IF FM-UWB receiver for short-range communications

A low-power FM-UWB receiver intended for short range communications in wireless sensor networks is presented in this paper. It utilizes an “approximate zero IF” architecture which combines a free-running ring oscillator as the RF LO with a modified delay-line demodulator. The main benefit comes from implementing the gain stages and the demodulator at the IF instead of RF, allowing significant power savings. Integrated in a 65nm CMOS technology, the whole receiver chain consumes 420μW from a 1V supply while achieving -68dBm sensitivity at the data rate of 100 kb/s.
Bmc Developmental Biology Quantitative Evaluation and Selection of Reference Genes in Mouse Oocytes and Embryos Cultured in Vivo and in Vitro

Background: Real-time PCR is an efficient tool to measure transcripts and provide valuable quantitative information on gene expression of preimplantation stage embryos. Finding valid reference genes for normalization is essential to interpret the real-time PCR results accurately, and understand the biological dynamics during early development. The use of reference genes also known as housekeeping genes is the most widely applied approach. However, the different genes are not systematically compared, and as a result there is no uniformity between studies in selecting the reference gene. The goals of this study were to compare a wide selection of the most commonly used housekeeping genes in mouse oocytes and preimplantation stage embryos produced under different culture conditions, and select the best stable genes for normalization of gene expression data.
Bidirectional light incidence in rigorous coupled-wave analysis applied to 4π-microscopy

The rigorous coupled-wave analysis (RCWA) is applied to the simulation of 4π-microscopy. To this end, we combine the concept of structured illumination with coherent two-sided light incidence. It is demonstrated how the latter is integrated into the RCWA framework. With these techniques we simulate two coherent counter-propagating converging beams incident upon a sample as in 4π-microscopy.
A Decision Support System for Local Government Regulatory Advice

This paper describes the implementation of a decision support system that helps non-technical front-line reception staff handle complex enquiries on a wide range of local government regulations. The paper describes the knowledge engineering and the knowledge level modelling undertaken for the project. The paper describes the design, implementation and architecture of the resulting distributed system that supports local customisation of the knowledge-base in a controlled managed process. The paper concludes by showing that INFOSHOP can be considered a CBR system that uses derivational replay to solve problems rather than the more common retrieval of problem-solution pairs.
Integrating Grid-Based and Topological Maps for Mobile Robot Navigation

Research on mobile robot navigation has produced two major paradigms for mapping indoor environments: grid-based and topological. While grid-based methods produce accurate metric maps, their complexity often prohibits efficient planning and problem solving in large-scale indoor environments. Topological maps, on the other hand, can be used much more efficiently, yet accurate and consistent topological maps are considerably difficult to learn in large-scale environments. This paper describes an approach that integrates both paradigms: grid-based and topological. Grid-based maps are learned using artificial neural networks and Bayesian integration. Topological maps are generated on top of the grid-based maps, by partitioning the latter into coherent regions. By combining both paradigms--grid-based and topological--, the approach presented here gains the best of both worlds: accuracy/consistency and efficiency. The paper gives results for autonomously operating a mobile robot equipped with sonar sensors in populated multi-room environments.
Diagnostic accuracy of fecal calprotectin in assessing the severity of inflammatory bowel disease: From laboratory to clinic

Background: Inflammatory bowel disease (IBD) involves chronic inflammation of the digestive tract. In the past decades, fecal calprotectin has been proposed as a useful biomarker for the differential diagnosis between IBD patients and healthy controls. We designed this study to evaluate the diagnostic ability of fecal calprotectin (FC) and conventional inflammatory markers in IBD patients. Methods: Thirty patients who underwent colonoscopy were cases and thirty healthy subjects undergoing colonoscopy as part of a medical check-up were the controls. These 2 groups were evaluated with regard to age and sex. Severity of the disease was evaluated based on disease endoscopic index. FC, Cross reactive protein (CRP) and Erythrocyte sedimentation rate (ESR) were measured using ELISA, colorimetric and Westergren methods, respectively. The obtained data were analyzed by independent test, correlation test and receiver operating characteristic (ROC) curve analysis. A p<0.05 was considered statistically significant. Results: Fecal calprotectin level in the case group increased compared to control group (p<0.05). Moreover FC has stronger correlation with disease endoscopic activity than conventional inflammatory markers (r=0.847 versus r= -0.44 for CRP and r=0.054 for ESR in Crohn's disease and r=0.798 versus r=0.463 for CRP and r=0.467 for ESR in ulcerative colitis). Receiver operating characteristic (ROC) curve analysis showed FC has larger area under the curve (AUC) than conventional inflammatory markers (1 versus 0.849 for CRP and 0.846 for ESR). Conclusion: Discriminating IBD patients from healthy controls was better for FC than conventional inflammatory markers. Additionally, the results produced by FC correlate with the severity of IBD.
Evidence-based instructional leadership in community colleges: a conceptual approach

Instructional leadership remains a complicated and debated issue for education. In fact, traditional theories of leadership from within both education and the organizational sciences increasingly face criticism. Drawing from ideas applicable to differentiated contexts of learning, this article develops an alternative model of instructional leadership for two-year, community colleges. It focuses on the potential and need for establishing a reciprocal relationship between administration and faculty in order to achieve effective instructional strategies through a pragmatic and research-based teaching practice that begins in the classroom. The model is itself justified through an analysis of literature on action research, organizational theory, community college strategic planning documents, and Carnegie Foundation recommendations.
Diversity and Spirituality Drive Young Adults at New Life Fellowship

Without extensive marketing or programming, New Life Fellowship in Elmhurst, Queens, NY, has managed to draw a growing number of young adults to its congregation housed in an imposing former Elks lodge on Queens Boulevard. Located in one of the most ethnically diverse neighborhoods in the United States, if not the world, New Life appears even more diverse than its surroundings on Sunday mornings—another feat accomplished without much initial planning.
How to Assess Transport in Animals?

The general principles for assessing solute and fluid transport across the peritoneum in animal models are not different from those in human studies. Animal models allow for extensive standardization of experimental conditions and also for sampling of peritoneal tissues for analysis. The present review will focus on (1) the scaling issue between various species, (2) how to measure intraperitoneal volume in animal models, (3) the impact of an indwelling catheter, (4) the difference between acute and chronic experiments, and (5) the particular problems associated with transport measurements in mice. If done correctly and after proper scaling, mass transfer area coefficients and clearance measurements show marked similarity among different species. Although animal models only partly mimic human peritoneal dialysis, they are valuable tools for understanding the basic physiology and biology of peritoneal dialysis.
Learning Decision Lists over Tree Patterns and Its Application

This paper introduces a new concept, a decision tree (or list) over tree patterns, which is a natural extension of a decision tree (or decision list), for dealing with tree structured objects. The learnability of this class is studied within the framework of the Probably Approximately Correct learning model and the Identi cation in the Limit model. It is found that the class k-node-DLRTP, a subclass of decision lists over regular tree patterns, is not polynomial time PAC learnable if NP6=RP, but that the class knode-DLRTP(m), a subclass of k-node-DLRTP where the number of variables in each tree pattern is bounded by m, is polynomial time PAC learnable. We also show that the class of decision lists over regular tree patterns is polynomial time inferable in the limit. Then we propose a more practical learning algorithm which employs heuristics based on an information theoretical evaluation function. This algorithm is applied to learning control strategies of rules in various domains, and its e ectiveness is shown.
Expression and splicing patterns of human papillomavirus type‐16 mrnas in pre‐cancerous lesions and carcinomas of the cervix, in human keratinocytes immortalized by HPV 16, and in cell lines established from cervical cancers

We have analysed the splicing patterns of human papillomavirus (HPV) type‐16 mRNAs in a human epithelial cell line immortalized by HPV 16 (HPKII), in cell lines established from cervical carcinomas (SiHa and CaSki) and in pre‐invasive and invasive carcinomas of the cervix. The presence of mRNA species previously described, which could encode the E6, E6I, E6II, E6III, E7, E2, E2C, E4, E5 and L1 proteins, was determined, using the RNA polymerase chain reaction (PCR) technique with primers that flank unique splice sites. The state of the viral DNA in the tumor biopsies was established by Southern blot analysis. The various HPV 16 transcripts could be detected in cell lines and in tumor biopsies. The size of the RNA PCR products were in agreement with the previously mapped splice sites. The full range of transcripts was revealed in the HPKII cell line and in a number of pre‐invasive carcinomas. Messenger RNAs which could encode the E6III, E4 and E5 proteins were most prevalent in all types of tumor. The overall results of DNA and RNA analyses in cell lines and tumor specimens indicate that (1) expression of either of the early or late transcripts studied is not specifically related to (a) tumor stage or (b) the physical state of the viral genome; and (2) alterations in the splicing patterns of HPV 16 transcripts may not be involved in tumor progression.
Quantification of synchronous contraction of left ventricle in normal subjects using ECG-gated-SPECT images

Intact heart muscles are believed to contract synchronously to produce maximum effective work at a minimum energy cost. Temporal correlation coefficients between the left ventricular volume and muscle contraction were introduced to assess the synchronicity of left ventricular contraction (synchronous contraction index, SCI), and applied to eight normal volunteers. Area-contraction and length-shortening parallel to and perpendicular to the long axis were computed from electrocardiogram (ECG)-gated single-photon emission computed tomographies (SPECT) using a homemade computer programme. The cardiac wall was divided into nine segments, and the average values of accumulation of perfusion agents, amplitude of contraction and SCI were obtained in each segment. The area-SCI was 91.4% ± 4.3% and relatively uniform over the whole cardiac wall (p = 0.014, analysis of variance (ANOVA)), whereas the accumulation and amplitude of contraction varied significantly in different segments (p < 0.0001, ANOVA). This study suggested that in normal subjects the myocardial contraction was synchronous, and that the amplitude of contraction was not spatially uniform.
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase–FGFR4 complex

Tumor cells use membrane type 1 matrix metalloproteinase (MT1-MMP) for invasion and metastasis. However, the signaling mechanisms that underlie MT1-MMP regulation in cancer have remained unclear. Using a systematic gain-of-function kinome screen for MT1-MMP activity, we have here identified kinases that significantly enhance MT1-MMP activity in tumor cells. In particular, we discovered an MT1-MMP/FGF receptor-4 (FGFR4) membrane complex that either stimulates or suppresses MT1-MMP and FGFR4 activities, depending on a tumor progression-associated polymorphism in FGFR4. The FGFR4-R388 allele, linked to poor cancer prognosis, increased collagen invasion by decreasing lysosomal MT1-MMP degradation. FGFR4-R388 induced MT1-MMP phosphorylation and endosomal stabilization, and surprisingly, the increased MT1-MMP in return enhanced FGFR4-R388 autophosphorylation. A phosphorylation-defective MT1-MMP was stabilized on the cell surface, where it induced simultaneous FGFR4-R388 internalization and dissociation of cell–cell junctions. In contrast, the alternative FGFR4-G388 variant down-regulated MT1-MMP, and the overexpression of MT1-MMP and particularly its phosphorylation-defective mutant vice versa induced FGFR4-G388 degradation. These results provide a mechanistic basis for FGFR4-R388 function in cancer invasion.
Irisin as a predictor of glucose metabolism in children: sexually dimorphic effects

Irisin, a novel myokine, increases energy expenditure and glucose tolerance and, thus, improves carbohydrate homeostasis in humans. This hormone has potential therapeutic applications for weight loss and improvement in insulin resistance in subjects with obesity and diabetes mellitus type 2 (T2DM). In this cross‐sectional study, we aimed to associate circulating levels of irisin and several anthropometric and metabolic parameters among Arab children.
Bifurcation of a Rural-Urban Regional Partnership: A Study of Hidden Dynamics

Region-based solutions present a promising avenue to addressing contemporary challenges facing municipalities. But regional formations require the messy reworking of networks of power among multiple stakeholders, often leading to power struggles. Challenges can be compounded when a rural-urban dimension is added to such an undertaking. This study examined the hidden power dynamics of a case involving 18 rural and urban municipalities in the Calgary region of Alberta called the Calgary Regional Partnership (CRP). In 2005 these municipalities voluntarily embarked on a major city-region initiative involving land-use planning and water sharing. However, by 2009 four rural municipalities had left the CRP, bifurcating the partnership along rural and urban lines. The dynamics of this case were traced through time and viewed through the lens of Foucault’s concepts of discourse and mechanisms of exclusion as well as Hajer’s concepts of metaphors, story-lines and discourse coalitions. The study demonstrates how mechanisms of exclusion led to the creation of dominant discourses, the formation of coalitions around counter-discourses, and the eventual disintegration of the rural-urban dimension of the partnership. Keywords: water, regionalism, Foucault, Hajer, discourse, power --------------------------------------------------- Resume Les solutions par region sont un moyen prometteur pour faire face aux defis contemporains des municipalites. Cependant, les formations regionales requierent le remaniement confus des reseaux de pouvoirs parmi de multiples parties prenantes, menant souvent a des luttes de pouvoir. Des defis peuvent etre amplifies lorsqu'une dimension rurale-urbaine est ajoutee a une telle entreprise. Cette etude examine les dynamiques de pouvoir cachees d'un cas impliquant 18 municipalites rurales et urbaines dans la region de Calgary, en Alberta, appelee Calgary Region Partnership (CRP) ou Region du Partenariat de Calgary. En 2005, ces municipalites volontaires se sont embarquees dans une initiative majeure municipalo-regionale impliquant la planification territoriale et le partage des eaux. Cependant, avant 2009, quatre municipalites rurales avaient deja quitte le CRP, separant les partenariats entre les lignes rurales et urbaines. Les dynamiques de ce cas ont ete tracees a travers le temps et considerees sous l'angle des concepts du discours et des mecanismes d'exclusion de Foucault ainsi que les concepts de metaphores, de scenarios et de coalitions discursives de Hajer. L'etude montre dans quelle mesure les mecanismes menent a la creation de discours dominants, a la formation de coalition autour de contre-courants, et a l'eventuelle desintegration d'une dimension rurale-urbaine d'un partenariat.
Development of a new experimental device and investigate human characteristics on visual feedback control and pointing movement

In present study, we developed a pointing movement experimental device with visual feedback control function that is capable of perform the cognitive psychological procedure relate to own hand movements. It can serve to determining the human characteristics of pointing movement with or without visual feedback restriction. The main part of present device consists of a touch monitor, one set of light control glass, a relay switch electric circuit and computer. The subjects can do the pointing movement on the touch monitor and the visual feedback restriction will carry out with a combination of light control glass and relay switch. In addition, all the control and measurement can be completed by the computer. However, present device can not realize the targets overlapping on the light control glass and touch monitor by bilateral ocular, owing to the human visual characteristics. So we compared pointing movement with bilateral ocular and lateral ocular with ten subjects. The results indicate that there is no significant difference between do pointing movement with bilateral and lateral ocular. Finally, ten young subjects consented to participate in a full vision and a vision restricted pointing movement tasks with lateral ocular. The results suggest that although the visual feedback was restricted, the pointing movement depend on the index difficulty of targets.
Is a p 53-responsive Gene Whose Four and a Half LIM Domain Protein Product Induces Apoptosis

DRAL is a four and a half LIM domain protein identified because of its differential expression between normal human myoblasts and the malignant counterparts, rhabdomyosarcoma cells. In the current study, we demonstrate that transcription of the DRAL gene can be stimulated by p53, since transient expression of functional p53 in rhabdomyosarcoma cells as well as stimulation of endogenous p53 by ionizing radiation in wild-type cells enhances DRAL mRNA levels. In support of these observations, five potential p53 target sites could be identified in the promoter region of the human DRAL gene. To obtain insight into the possible functions of DRAL, ectopic expression experiments were performed. Interestingly, DRAL expression efficiently triggered apoptosis in three cell lines of different origin to the extent that no cells could be generated that stably overexpressed this protein. However, transient transfection experiments as well as immunofluorescence staining of the endogenous protein allowed for the localization of DRAL in different cellular compartments, namely cytoplasm, nucleus, focal contacts, as well as Z-discs and to a lesser extent the M-bands in cardiac myofibrils. These data suggest that downregulation of DRAL might be involved in tumor development. Furthermore, DRAL expression might be important for heart function.
Unrecognized emboli to the lungs with subsequent cor pulmonale.

IN recent years interest in pulmonary embolization has centered largely about preventive measures, with emphasis on leg-vein ligation and anticoagulant therapy.1 , 2 The principal cause for concern has been the acute syndrome of pulmonary infarction with its all too familiar picture of chest pain, hemoptysis and sometimes sudden death. It is well known, however, that pulmonary emboli may occur without clinical recognition,3 4 5 and the incidental post-mortem finding of organized emboli involving scattered vessels is not uncommon. There is a special group of patients, however, in whom the emboli are so extensive that they ultimately result in serious obstruction to the flow .