Miracle-dz/UniFAR-FTUs huggingface dataset:
Estimating the Impact of Taxes on the Economic Growth in the United States

Abstract In a research paper, the authors provide an empirical approach to taxes and economic growth in the United States in the period 1996-2016. The basic goal is to explore how taxes affect economic growth. The subject of the research is measuring the effects of tax revenue growth and tax form as a personal income tax, corporate income tax and social security contributions on gross domestic product as a proxy for economic growth. Methodology framework includes several tests to clear the potential problem of heteroscedasticity, autocorrelation, multicollinearity and specification of the model. Based on diagnostic tests, a regression model is adequately created where fundamental econometric procedures are applied. Correlation matrix reflects a strong and positive relationship between tax revenue growth and corporate income tax on the one side and gross domestic product growth, on the another side. Also, personal income tax and social security contributions are weakly related to gross domestic product growth. The model shows a significant effect of tax revenue growth and social security contributions, while personal income tax and corporate income tax do not have a significant impact on gross domestic product growth. Interestingly, personal income tax as the main tax form in the tax structure of the United States has no significant impact on economic growth compared to social security contributions which percentage share is lesser.
Consumption of a Polyphenol-Rich Grape-Wine Extract Lowers Ambulatory Blood Pressure in Mildly Hypertensive Subjects

Polyphenols in grape and wine have been suggested to contribute to the cardiovascular health benefits of the Mediterranean lifestyle. The reported effects of grape products on blood pressure (BP) remain, however, equivocal. In a double-blind placebo controlled crossover study, the effect of two grape extracts on BP and vascular function was assessed in 60 untreated, mildly hypertensive subjects after four weeks intervention. Both extracts (grape-red wine and grape alone) had high concentrations of anthocyanins and flavonols, but the grape alone was relatively poor in catechins and procyanidins. Parameters measured included ambulatory and office BP, flow-mediated vasodilation, arterial distensibility, platelet function and plasma lipoproteins. Results showed that 24-hour ambulatory systolic/diastolic BPs were significantly lower in the grape-wine extract intervention (135.9 ± 1.3/84.7 ± 0.8 mmHg; mean ± SEM) compared to placebo (138.9 ± 1.3/86.6 ± 1.2 mmHg), predominantly during daytime. Plasma concentrations of the vasoconstrictor endothelin-1 decreased by 10%, but other measures of vascular function were not affected. Grape juice extract alone had no effect on BP or any measures of vascular function. Polyphenol-rich food products, and may be specifically catechins and procyanidins, may thus help sustain a healthy BP and contribute to the healthy Mediterranean lifestyle.
Quantitative magnetic resonance spectroscopy in the entire human cervical spinal cord and beyond at 3T

Quantitative magnetic resonance spectroscopy (MRS) amends differential diagnostics of neurological pathology. However, due to technical challenges, it has rarely been applied to the spinal cord and has mainly been restricted to the very upper part of the cervical spine. In this work, an improved acquisition protocol is proposed that takes technical problems as strong magnetic field inhomogeneities, pulsatile flow of the cerebrospinal fluid (CSF), and small voxel size into account. For that purpose, inner‐volume saturated point‐resolved spectroscopy sequence (PRESS) localization, ECG triggering, and localized higher‐order shimming and F0 determination, based on high‐resolution cardiac‐triggered static magnetic field B0 mapping, are combined. For inner‐volume saturation a highly selective T1‐ and B1‐insensitive outer‐volume suppression (OVS) sequence based on broadband RF pulses with polynomial‐phase response (PPR) is used. Validation is performed in healthy volunteers and patients with multiple sclerosis and intramedullary tumors. The applicability of spinal cord MRS is extended to the entire cervical spine. Spectral quality and its consistency are improved. In addition, high quality MRS patient data from a lesion that occluded the spinal canal in the thoracic spinal cord could be acquired. A quantitative analysis of patient spectra and spectra from healthy volunteers at different positions along the spinal cord underlines the diagnostic value of spinal cord MRS. Magn Reson Med 59:1250–1258, 2008. © 2008 Wiley‐Liss, Inc.
Perspectives for the development of key industrial capabilities for Canada’s defence sector

ABSTRACT With the Canada First Defence Strategy, Canada has put forth a major opportunity to reconcile national security imperatives and industrial policy. The Jenkins Report (2013) set out to examine ways to use that procurement effort to foster key industrial capabilities (KICs) that would put the Canadian defence industry at an advantage both nationally and internationally. The Canadian defence industry should then develop highly focused capabilities with a view to moving up global value chains. As such, KICs that hold the best potential should be selected. They should be sustained through a range of strategies that are however contingent on the elimination of policy gaps. This leads to a balancing act between the need to control intellectual property assets versus accessing them in a world where national boundaries are eroded. Canada’s industry should target opportunities outside North America while continuing to focus on better integration with the North American industry.
Influence of transformational-servant leadership styles and justice perceptions on employee burnout: a moderated mediation model

Today's managers need to possess strong leadership skills in order to combat the dynamic organisational demands. This study provides a unique insight into how two popular leadership styles - transformational leadership and servant leadership, interact when faced with employee burnout. A moderated mediation model is formulated with transformational leadership moderating the indirect effect of servant leadership on employee burnout through organisational justice. This model is empirically tested and proved in an information technology firm. The results support the model and provide new avenues for leadership research by providing a unique insight on how different leadership styles can be effective together. The practical implications of this study and directions for future research are discussed.
BPSK Subcarrier Intensity Modulated Free-Space Optical Communications in Atmospheric Turbulence

Free-space optical communications (FSO) propagated over a clear atmosphere suffers from irradiance fluctuation caused by small but random atmospheric temperature fluctuations. This results in decreased signal-to-noise ratio (SNR) and consequently impaired performance. In this paper, the error performance of the FSO using a subcarrier intensity modulation (SIM) based on a binary phase shift keying (BPSK) scheme in a clear but turbulent atmosphere is presented. To evaluate the system error performance in turbulence regimes from weak to strong, the probability density function (pdf) of the received irradiance after traversing the atmosphere is modelled using the gamma-gamma distribution while the negative exponential distribution is used to model turbulence in the saturation region and beyond. The effect of turbulence induced irradiance fluctuation is mitigated using spatial diversity at the receiver. With reference to the single photodetector case, up to 12 dB gain in the electrical SNR is predicted with two direct detection PIN photodetectors in strong atmospheric turbulence.
Symbolic equids and Kushite state formation: a horse burial at Tombos

Abstract The recent discovery of a well-preserved horse burial at the Third Cataract site of Tombos illuminates the social significance of equids in the Nile Valley. The accompanying funerary assemblage includes one of the earliest securely dated pieces of iron in Africa. The Third Intermediate Period (1050–728 BC) saw the development of the Nubian Kushite state beyond the southern border of Egypt. Analysis of the mortuary and osteological evidence suggests that horses represented symbols of a larger social, political and economic movement, and that the horse gained symbolic meaning in the Nile Valley prior to its adoption by the Kushite elite. This new discovery has important implications for the study of the early Kushite state and the formation of Kushite social identity.
Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19.

Experiments using recombinant yeast-expressed human liver cytochromes P450 confirmed previous literature data indicating that ticlopidine is an inhibitor of CYP 2C19. The present studies demonstrated that ticlopidine is selective for CYP 2C19 within the CYP 2C subfamily. UV-visible studies on the interaction of a series of ticlopidine derivatives with CYP 2C19 showed that ticlopidine binds to the CYP 2C19 active site with a K(s) value of 2.8 +/- 1 microM. Derivatives that do not involve either the o-chlorophenyl substituent, the free tertiary amine function, or the thiophene ring of ticlopidine did not lead to such spectral interactions and failed to inhibit CYP 2C19. Ticlopidine is oxidized by CYP 2C19 with formation of two major metabolites, the keto tautomer of 2-hydroxyticlopidine (1) and the dimers of ticlopidine S-oxide (TSOD) (V(max) = 13 +/- 2 and 0.4 +/- 0.1 min(-1)). During this oxidation, CYP 2C19 was inactivated; the rate of its inactivation was time and ticlopidine concentration dependent. This process meets the chemical and kinetic criteria generally accepted for mechanism-based enzyme inactivation. It occurs in parralel with CYP 2C19-catalyzed oxidation of ticlopidine, is inhibited by an alternative well-known substrate of CYP 2C19, omeprazole, and correlates with the covalent binding of ticlopidine metabolite(s) to proteins. Moreover, CYP 2C19 inactivation is not inhibited by the presence of 5 mM glutathione, suggesting that it is due to an alkylation occurring inside the CYP 2C19 active site. The effects of ticlopidine on CYP 2C19 are very analogous with those previously described for the inactivation of CYP 2C9 by tienilic acid. This suggests that a similar electrophilic intermediate, possibly a thiophene S-oxide, is involved in the inactivation of CYP 2C19 and CYP 2C9 by ticlopidine and tienilic acid, respectively. The kinetic parameters calculated for ticlopidine-dependent inactivation of CYP 2C19, i.e., t(1/2max) = 3.4 min, k(inact) = 3.2 10(-3) s(-1), K(I) = 87 microM, k(inact)/K(I) = 37 L.mol(-1). s(-1), and r (partition ratio) = 26 (in relation with formation of 1 + TSOD), classify ticlopidine as an efficient mechanism-based inhibitor although somewhat less efficient than tienilic acid for CYP 2C9. Importantly, ticlopidine is the first selective mechanism-based inhibitor of human liver CYP 2C19 and should be a new interesting tool for studying the topology of the active site of CYP 2C19.
Local Currency Bond Markets

We analyze the development of 49 local bond markets. Our main finding is that policies and laws matter: Countries with stable inflation rates and strong creditor rights have more developed local bond markets and rely less on foreign-currency-denominated bonds. The results suggest that "original sin" is a misnomer. Emerging economies are not inherently dependent upon foreign-currency debt. Rather, by improving policy performance and strengthening institutions they may develop local currency bond markets, reduce their currency mismatch, and lessen the likelihood of future crises.
Creativity in events: the untold story

The purpose of this paper is to report on untold stories that not only illustrate the creativity but also complexity of working in outdoor events. There has been global interest in the creative industries and the creative economy more generally. Events have not been identified or categorised as part of this. Experiences have been identified as part of the creative sectors (NESTA, 2006) and events are seen as experiences (Jackson, 2006; Berridge 2007). There has been little research undertaken about the creative nature of event experiences, especially in how they are created. ,A theoretical framework was created from literature on creativity more generally to inform the Creativity in Events research project. Interviews with those working in the outdoor events sector were the basis of the qualitative stage of the research project investigating the phenomenon of creativity in events. ,This paper identifies the core facets of creativity in the management of outdoor events. These were fluency, originality, imagination, elaboration, environment and complexity. A vignette is used to illustrate the intricacy of the nature of creativity in the production of outdoor event experiences. The overall findings were that event management was both creative and pragmatic and that both are necessary. There was a need for a creative environment with processes and familiarity that aided inspiration and originality. ,The background and findings are relevant to recognising events as part of the wider creative economy. A greater understanding of the nature of creativity in events informs both education and practice.
College Students’ Attitudes toward Debt

College student debt has gained much attention. This article uses survey data to examine the influence of psychological factors on college student attitudes toward debt. In the sample of 283 undergraduates enrolled in a personal finance elective course, financial self-confidence was significantly related to debt attitude, indicating that less financially self-confident students tended to have more positive attitudes toward debt. Two other psychological factors, ability to delay gratification and comparing oneself to others, were not significantly related to debt attitudes. Among the control variables, only gender was significantly related; women had more negative attitudes toward debt than men. College major, involvement with parents about personal finance, and financial knowledge were not significantly related to student attitudes toward debt. Future researchers should consider reexamining the use of the scales used in this research. Although the scales had been used by previous researchers, they may have less relevance to young adults whose debt attitudes were no doubt influenced by the Great Recession of 2007-2009.
The Influence of Extracorporeal Circulation on the Susceptibility of Erythrocytes to Oxidative Stress

Extracorporeal circulation (ECC), a necessary and integral part of cardiac surgery, can itself induce deleterious effects in patients. The pathogenesis of diffuse damage of several tissues is multifactorial. It is believed that circulation of blood extracorporeally through plastic tubes causes a whole body inflammatory response and a severe shear stress to blood cells. The aim of this study was to evaluate the level of oxidative stress and its deleterious effect on red blood cell (RBC) before (pre-ECC), immediately after (per-ECC) and 24 h after an ECC (24 h post-ECC). Several indicators of extracellular oxidative status were evaluated. The ascorbyl free radical (AFR) was directly measured in plasma using electron spin resonance (ESR) spectroscopy and expressed with respect to vitamin C levels in order to obtain a direct index of oxidative stress. Allophycocyanin assay was also used to investigate the plasma antioxidant status (PAS). Indirect parameters of antioxidant capacities of plasma such as vitamin E, thiol and uric acid levels were also quantified. RBC alterations were evaluated through potassium efflux and carbonyl levels after action of AAPH, a compound generating carbon centered free radicals. No changes in plasma uric acid and thiols levels were observed after ECC. However, vitamin E levels and PAS were decreased in per-ECC and 24 h post-ECC samples. Vitamin C levels were significantly lower in 24 h post-ECC and the AFR/ vitamin C ratio was increased. Differences in results had been noted when measurements took account of hemodilution. Increases of uric acid and thiols levels were observed after ECC. Vitamin E levels were not modified. However after hemodilution correction a significant decrease of vitamin C level was noted in 24 h post-ECC samples as compared to per-ECC sample. Whatever the way of measurement, vitamin C levels decreased suggesting the occurrence of ECC induced-oxidative stress. Concerning RBC, in the absence of AAPH, extracellular potassium remained unchanged between pre-, per- and 24 h post-ECC. AAPH induced a significant increase in extracellular potassium and carbonyls levels of RBC membranes, which was not modified by ECC. These results suggest the absence of alterations of RBC membrane during ECC despite the occurrence of disturbances in PAS. Such protection is of particular importance in a cell engaged in the transport of oxygen and suggests that RBC are equipped with mechanisms affording a protection against free radicals.
The Role of Financial Ratios in the Variance of Stock Trading Volume in Emerging Stock Markets

ABSTRACT The study used quarterly panel data of 6 years from 2010 to 2015 of all companies listed on both Vietnamese stock markets including the Ho Chi Minh City Stock Exchange and Ha Noi Stock Exchange, and on three leading industries consisting of insurance-banking, foodstuff, and real estate to explore the relationship among four key financial ratios and stock trading volume. Two models, fixed effects model (FEM) and random effects model (REM), with robust standard errors, were applied for this study. The key findings showed that earnings before tax on sales, debt on owner’s equity, and owner’s equity on total assets significantly influenced trading volume.
Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine

The 4-aminoquinolines chloroquine (CQ) and amodiaquine (AM) were used to treat Gambian children with uncomplicated falciparum malaria in a randomized drug trial. Blood samples were taken immediately before treatment (day 0), and at day 7 and day 28 after treatment. Samples from those parasitologically positive at day 7 following treatment (‘early positives’) and those positive at day 28 but negative at day 7 (‘late positives’) have been studied by PCR followed by restriction enzyme digestion to determine the allelic status of the pfmdr 1 locus at the codon-86 position (asparagine or tyrosine), previously associated with resistance to CQ. A significantly higher prevalence of the tyr-86 allele was observed in samples taken immediately before treatment (day 0) in the early positives group when compared with the late positives group. This suggests the tyr-86 allele contributes to drug resistance in the early positives group. This association remained significant for both CQ and AM groups, implying a common genetic basis of resistance. Predominance of the allele at day 7 is consistent with a strong selection in the first week following treatment. In the late positives group, a significantly higher prevalence of the tyr-86 allele was observed in the samples at day 28 when compared with those at day 0, suggestive of selection during the period day 7 to day 28. Differences were observed in the extent of this selection in the CQ and AM groups. The samples were genotyped at 3 unlinked polymorphic loci. These analyses suggested that most parasites observed at day 7 were probably recrudescences whereas most of those at day 28 were reinfections.
Exercise‐induced changes in respiratory impedance in young wheezy children and nonatopic controls

Exercise‐induced bronchoconstriction (EIB) is a specific sign of active asthma, but its assessment in young children may be difficult with lung function techniques requiring active cooperation. The aim of the study was to assess the normal pattern of exercise‐induced responses of respiratory impedance by using impulse oscillometry (IOS), and to investigate how these responses discriminate wheezy children from control subjects. IOS measurements were performed in a consecutive sample of wheezy children aged 3–7 years (n = 130) and in an aged matched control group of nonatopic children without respiratory symptoms (n = 79) before and after a free running test. After exercise, wheezy children showed significantly larger responses in respiratory resistance (Rrs5), reactance (Xrs5), and the resonance frequency (Fr) than the control subjects. In the control group, the upper 95% confidence limit of the maximal change was 32.5% for Rrs5, 85.7% for Xrs5, and 53.1% for Fr. By using analysis of receiver operating characteristics, the change in Rrs5 distinguished the wheezy children from the control subjects more effectively than change in Xrs5 or Fr. In wheezy children, the response was significantly effected by the outdoor temperature and exercise intensity in terms of maximum heart rate. In conclusion, an increase of 35% in Rrs5 after a free running test can be regarded as an abnormal response. Wheezy children show an enhanced airway response, which is clearly distinguishable from the control subjects. IOS is a feasible method to detect EIB in young children. Pediatr Pulmonol. 2008; 43:538–544. © 2008 Wiley‐Liss, Inc.
Optimal Illumination and Color Consistency for Optical Remote-Sensing Image Mosaicking

Illumination and color consistency are very important for optical remote-sensing image mosaicking. In this letter, we propose a simple but effective technique that simultaneously performs image illumination and color correction for multiview images. In this framework, we first present an uneven illumination removal algorithm based on bright channel prior, which guarantees the illumination consistency inside a single image. We then adapt a pairwise color-correction method to coarsely align the color tone between source and reference images. In this stage, we give a new single-image quality metric which combines brightness deviation, color cast, and entropy together for automatic reference-image selection. Finally, we perform a least-squares adjustment (LSA) procedure to obtain optimal illumination and color consistency among multiview images. In detail, we first perform a pairwise image matching by using SIFT algorithm; once sparse local patch correspondences obtained, the illumination and color relationship between images can be established based on a global gamma correction model; the illumination and color errors can then be minimized by LSA. Extensive experiments on both challenging synthetic and real optical remote-sensing image data sets show that it significantly outperforms the compared state-of-the-art approaches. All the source code and data sets used in this letter are made public.11https://sites.google. com/site/jiayuanli2016whu/home