Miracle-dz/UniFAR-FTUs huggingface dataset:
Improved Hysteresis Current Control of a Single Phase, Three Level, Double PFC Converter

Single ended, single phase, power factor corrector (PFC) Boost Converter, is one of the most popular AC/DC converters, because of a number of advantages i.e. its step up voltage ratio, simplest topology and high efficiency. However, for high voltage or high power applications, three level PFC converter is one of the most promising solutions. For high power applications, current operation frequency and Bandwidth must be limited to avoid Electromagnetic EMI interference. This paper presents a fixed frequency hysteresis current control for Three level Single-Phase, Boost double PFC Converter. The proposed methodoly presents hysteresis current control with adaptive band error to constrain switching frequency for a given range. A fast response, a relative small bandwidth and reduced harmonic content are qualities of the technique proposed; furthermore, coupling Output Voltage problem is avoided, by means of compensating current reference. Simulation results confirm the proposed technique.
A corpus study of the prosody of polysyllabicwords in Mandarin Chinese

This paper presents a corpus study of polysyllabic words in Standard Mandarin Chinese. In particular, this study investigates their prosodic features with respect to the notions of prosodic strength and stress. We find a robust strong-weak alternation with respect to F0, but different patterns for duration. In disyllabic words the first syllable tends be slightly longer than the second. However, for three and four syllable words the last syllable is the longest, followed by the first. These patterns suggest that F0 is a reliable phonetic indicator of metrical structure in Mandarin Chinese, rather than duration.
Checking and Measuring the Architectural Structural Conformance of Object-Oriented Systems

Abstract : The benefits of architectural analyses are only achieved if one can guarantee that the implementation conforms to the architecture. We propose an approach for checking and measuring the structural conformance of a software system's implementation to its execution architecture. In contrast to existing approaches, our approach uses static analyses, and works with existing Java-like programming languages, existing object-oriented designs and existing integrated development environments. We address the problem with a multi-pronged approach, as follows: "a" express and enforce architectural intent related to object encapsulation and communication directly in code using ownership domain annotations; "b" extract a sound execution architecture from the annotated program semi-automatically; and "c" compare the as-built extracted architecture to the as-designed architecture semi-automatically; and "d" obtain a measure of conformance. We present an initial evaluation of the approach on two extended examples. In both cases, we extract as- built execution architectures that convey meaningful abstractions, convert them into standard component-and-connector architectures, and obtain measures of conformance between the as-designed and the as-built architectures that seem consistent with our intuition.
Similarity-based Decision Models ∗

This paper introduces similarity-based models of decision making for decision situations in which data on the attributes of options are not available. We propose that an actor, to evaluate a given option, can rely on the utility similar actors derive from this option, or on the utility she derived from similar options. We propose two models to assess the similarity of actors and options. We analyze the proposed models through numerical analyses, and illustrate their workings on a dataset in which reviewers rate restaurants. We nd that the proposed decision making models provide reasonable prediction even if information is not available on the attributes of the options and/or the preferences of the actors. Finally, we discuss the ndings and the implications to other domains of decision making. In reality, all arguments from experience are founded on the similarity which we discover among natural objects, and by which we are induced to expect e ects similar to those which we have found to follow from such objects. (.) From causes which appear similar we expect similar e ects. This is the sum of all our experimental conclusions. David Hume: An Enquiry Concerning Human Understanding, 2004: 21 (1748) ∗This paper bene tted from discussions with Jerker Denrell. All remaining errors are my own. Corresponding address: USI Institute of Management, Via Bu 13, Lugano, Switzerland 6900. Email: kovacsb@usi.ch
Therapeutic Mechanism in Seasonal Affective Disorder: Do Fluoxetine and Light Operate Through Advancing Circadian Phase?

In the context of Lewy's phase delay hypothesis, the present study tested whether effective treatment of winter Seasonal Affective Disorder (SAD) is mediated by advancing of circadian phase. Following a baseline week, 78 outpatients with SAD were randomized into 8 weeks of treatment with either fluoxetine and placebo light treatment or light treatment and placebo pill. Depression levels were measured on the Ham17+7 and the BDI‐II, and circadian phase was estimated on the basis of daily sleep logs and self‐reported morningness‐eveningness. Among the 61 outpatients with complete data, both treatments were associated with significant antidepressant effect and phase advance. However, pre‐ and post‐treatment comparisons found that the degree of symptom change did not correlate with the degree of phase change associated with treatment. The study therefore provides no evidence that circadian phase advance mediates the therapeutic mechanism in patients with SAD. Findings are discussed in terms of the limitations of the circadian measures employed.
Association of Adiponectin With Cerebrovascular Disease: A Nested Case–Control Study

Background and Purpose— Even though adiponectin is associated with many traditional cardiovascular risk factors, studies assessing the association between adiponectin and cerebrovascular disease (CVD) are scarce. We assessed the odds of CVD at different plasma levels of adiponectin. Methods— A nested case–control study was conducted involving 5243 subjects, drawn from 12 490 subjects of the Jichi Medical School Cohort Study, whose blood samples had been drawn between 1992 and 1995. Over an average of 9.7 years of follow-up, through 2005, 179 patients with cerebrovascular events were identified, in addition to 630 controls matched for age, sex, and community (total n=809). Odds ratios were estimated relative to the highest quartile of adiponectin level. Results— There was neither a significant difference in the odds of stroke between the lowest and highest adiponectin quartiles, nor a significant linear trend toward a reduced risk of stroke at higher adiponectin levels. These results did not change after excluding participants with diabetes, impaired glucose metabolism, or metabolic syndrome. The odds of ischemic stroke in the lowest quartile were significantly higher than in the highest quartile, when adjusted for age and sex (OR 2.04 [95% CI, 1.09 to 3.80]). However, the odds failed to achieve statistical significance when adjusted further for other cardiovascular risk factors. Again exclusion of subjects with diabetes, impaired glucose metabolism, or metabolic syndrome did not alter results. Conclusions— Adiponectin levels are not independently associated with stroke or brain infarction. The use of adiponectin as a cerebrovascular disease predictor may be premature.
An effective thermal conductivity model for fractal porous media with rough surfaces

Quantitative evaluation of the effective thermal conductivity of porous media has received wide attention in science and engineering since it is a key thermophysical parameter in characterizing heat transfer properties. Based on fractal characters of tortuous capillary tubes and rough surfaces in micro-pores, we proposed a theoretical model of the effective thermal conductivity in porous media with rough surfaces. This model considers the geometrical parameters of porous media, including porosity, micro-pore fractal dimension, tortuosity fractal dimension, and relative roughness. The calculated normalized effective thermal conductivity was then validated against published experimental data. The results show good agreement between them. The influence of geometrical factors, porosity and relative surface roughness, on the effective thermal conductivity in porous media with rough surfaces are discussed and analyzed extensively. Cited as : Qin, X. , Zhou, Y. , Sasmito, A.P. An effective thermal conductivity model for fractal porous media with rough surfaces. Advances in Geo-Energy Research, 2019, 3(2): 149-155, doi: 10.26804/ager.2019. 02.04.
The central domain of Rhizobium meliloti NifA is sufficient to activate transcription from the R. meliloti nifH promoter

The Rhizobium meliloti nifA product (NifA) shares extensive homology in its central region and at its C-terminal end with Rhizobium leguminosarum DctD and with NtrC from several species. All three proteins are transcriptional activators of NtrA (RpoN)-RNA polymerase-dependent promoters. Several large deletions of R. meliloti NifA were constructed to investigate the role of the conserved and divergent domains of NifA in transcriptional activity and posttranscriptional regulation by oxygen. The ability of NifA expressed from the Escherichia coli lacZ promoter to activate the R. meliloti nifH promoter in E. coli and R. meliloti was tested under a range of defined atmospheric oxygen partial pressures. Deletion of the divergent N-terminal domain of NifA had little effect on NifA activity and no effect on oxygen sensitivity. Deletion of the conserved C-terminal helix-turn-helix motif of NifA did not eliminate NifA-dependent activation of the nifH promoter, although it did decrease NifA activity about twofold in E. coli and 10-fold in R. meliloti. A NifA carrying both the N-terminal and C-terminal deletions and consisting of only the central highly conserved domain and 50 divergent amino acids retained the ability to activate transcription from the nifH promoter. The transcriptional activity of the conserved central domain is consistent with the prediction that the core domain is the part of NifA which interacts with the transcriptional machinery to stimulate transcription.
Simultaneous Control of Subthreshold and Gate Leakage Current in Nanometer-Scale CMOS Circuits

Power gating has been widely used to reduce subthreshold leakage. However, its efficiency degrades very fast with technology scaling due to the gate leakage of circuits specific to power gating, such as storage elements and output interface circuits with a data-retention capability. A new scheme called supply switching with ground collapse is proposed to control both gate and subthreshold leakage in nanometer-scale CMOS circuits. Compared to power gating, the leakage is cut by a factor of 6.3 with 65nm and 8.6 with 45nm technology. Various issues in implementing the proposed scheme using standard-cell elements are addressed, from RTL to layout. The proposed design flow is demonstrated on a commercial design with 90nm technology, and the leakage saving by a factor of 32 is observed with 3% and 6% of increase in area and wirelength, respectively.
Enhancement and Suppression of Heat Transfer by MHD Turbulence

We study the effect of turbulence on heat transfer within magnetized plasmas for energy injection velocities both larger and smaller than the Alfvén speed. We find that in the latter regime the heat transfer is partially suppressed, while in the former regime the effects of turbulence depend on the intensity of driving. In fact, the scale lA at which the turbulent velocity is equal to the Alfvén velocity is an important new parameter. When the electron mean free path λ is larger than lA, the stronger the turbulence, the lower the thermal conductivity by electrons. The turbulent motions, however, induce their own advective heat transport, which, for the parameters of intracluster medium, provides effective heat diffusivity that exceeds the classical Spitzer value.
Human Talent Prediction in HRM using C4.5 Classification Algorithm

In HRM, among the challenges for HR professionals is to manage an organization's talents, especially to ensure the right person for the right job at the right time. Human talent prediction is an alternative to handle this issue. Due to that reason, classification and prediction in data mining which is commonly used in many areas can also be implemented to human talent. There are many classification techniques in data mining techniques such as Decision Tree, Neural Network, Rough Set Theory, Bayesian theory and Fuzzy logic. Decision tree is among the popular classification techniques, which can produce the interpretable rules or logic statement. The generated rules from the selected technique can be used for future prediction. In this article, we present the study on how the potential human talent can be predicted using a decision tree classifier. By using this technique, the pattern of talent performance can be identified through the classification process. In that case, the hidden and valuable knowledge discovered in the related databases will be summarized in the decision tree structure. In this study, we use decision tree C4.5 classification algorithm to generate the classification rules for human talent performance records. Finally, the generated rules are evaluated using the unseen data in order to estimate the accuracy of the prediction result. Keywords-Human talent; Classification, Prediction; Decision Tree; C4.5 classifier; Classification Algorithm
Investigation of the Hydrogen Stratification of the Metal of the Active Gas Pipeline

One of the most common types of metal destruction in the oil and gas industry is hydrogen embrittlement. Hydrogen corrosion is a complex of negative effects of hydrogen on steel, leading to the destruction of metal structures. Hydrogen passes through a defect-free metal, without lingering in it. In the presence of defects, hydrogen is retained in the metal forming a brittle solid solution, metal stratification along the segregation streamer, blistering. Studies of the metal of a gas pipeline made of steel 09G2S are presented in the article. The sample was selected from the local zone of destruction in the condensate collector, the metal of the pipe had typical for hydrogen corrosion stratifications. The scope of the study was identification of the most dangerous part of hydrogen corrosion on the sample taken from the local zone of destruction. Studies on the chemical composition and mechanical properties of 09G2S steel were also carried out. Stress-related characteristics of the metal microstructure of the failed gas pipeline were obtained and the character of the destruction progress was revealed. The presence of sulfides cluster in the metal of studied pipe was determined applying metallographic method for determining nonmetallic inclusions.
Measuring thrombin generation as a tool for predicting hemostatic potential and transfusion requirements following trauma

BACKGROUND Thrombin is the central coagulation protease that activates clotting proteins, triggers platelet aggregation, and converts fibrinogen to fibrin. Relationships between thrombin generation (TG) and clinical outcomes have not been defined following trauma. We hypothesize that TG is predictive of transfusion requirements and patient outcomes. METHODS Plasma was collected from 406 highest-level activation trauma patients upon admission and 29 healthy donors. Standard coagulation tests were performed, and TG was measured by calibrated automated thrombogram. Mann-Whitney U-tests were used to compare healthy versus trauma patients, and subgroup analyses were used to compare hypocoagulable versus nonhypocoagulable patients. Hypocoagulability was determined by area under the receiver operating characteristic curve analysis and was defined as peak TG of less than 250 nM. Multiple logistic regressions were used to assess the ability of TG to predict massive transfusion and mortality. RESULTS The median (interquartile range) age was 39 years (28–52 years), with an Injury Severity Score (ISS) of 17 (9–26). The trauma patients had greater TG (peak, 316.2 nM [270.1–355.5 nM]) compared with the healthy controls (124.6 nM [91.1–156.2 nM]), p < 0.001. The overall rate of hypocoagulability was 17%. The patients with peak TG of less than 250 nM were more severely injured (ISS, 25 [13–30] vs. 16 [9–25], p = 0.003); required more transfusions of red blood cells (p = 0.02), plasma (p = 0.003), and platelets (p = 0.006); had fewer hospital-free days (p = 0.001); and had increased mortality (10% vs. 3% at 24 hours, p = 0.006, and 29% vs. 11% at 30 days, p = 0.0004). Peak TG of less than 250 nM was predictive of massive transfusion (odds ratio, 4.18; p = 0.01) and 30-day mortality (odds ratio, 2.78; p = 0.02). Finally, peak TG was inversely correlated with standard coagulation tests. CONCLUSION While the physiologic response to injury is to upregulate plasma procoagulant activity, the patients with reduced TG required more transfusions and had poorer outcomes. Measuring TG may provide an exquisitely sensitive tool for detecting disturbances in the enzymatic phases of coagulation in critically injured patients. LEVEL OF EVIDENCE Prognostic/epidemiologic study, level III.
Omics Meets Biology: Application to the Design and Preclinical Assessment of Antivenoms

Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact worldwide, mostly affecting poor people involved in agricultural activities in Africa, Asia, Latin America and Oceania. A key issue that complicates the treatment of snakebite envenomings is the poor availability of the only validated treatment for this disease, antivenoms. Antivenoms can be an efficacious treatment for snakebite envenoming, provided they are safe, effective, affordable, accessible and administered appropriately. The shortage of antivenoms in various regions, particularly in Sub-Saharan Africa and some parts of Asia, can be significantly alleviated by optimizing the use of current antivenoms and by the generation of novel polyspecific antivenoms having a wide spectrum of efficacy. Complementing preclinical testing of antivenom efficacy using in vivo and in vitro functional neutralization assays, developments in venomics and antivenomics are likely to revolutionize the design and preclinical assessment of antivenoms by being able to test new antivenom preparations and to predict their paraspecific neutralization to the level of species-specific toxins.
Nanocomposite Capacitors with Significantly Enhanced Energy Density and Breakdown Strength Utilizing a Small Loading of Monolayer Titania

The dielectric capacitor with high electric energy density is demanded for modern electronic and electrical power systems. However, their energy density is considerably limited by a low dielectric constant and low breakdown strength. Here, thin flexible polymer nanocomposites with high energy density are obtained by only adding a small loading of 2D monolayer titania along with concurrent improvements of dielectric constant and breakdown strength. This work not only first reveals that monolayer titania is an excellent filler that can be comparable to existing fillers in nanocomposite capacitors but also provides a facile approach to thin flexible compact dielectric films with ultrahigh energy density and breakdown strength for energy storage applications.
Silicon Micromachined W-Band Bandpass Filter Using DRIE Technique

A silicon micromachined W-band 3-pole bandpass filter using deep reactive ion etching technology with stacked silicon substrates is presented for the first time. The dimensions of the waveguide filter are calculated based on EM theory and optimized using the Ansoft HFSS 9.2 full wave simulator. The measured center frequency is 92.45GHz. The passband insertion loss is between 1.1 dB and 1.3 dB. The measured bandwidth is 4.83%. The attenuation is more than 30dB at 9GHz away from the center frequency
Structural Relaxation of L-Alanine Molecule with Water Molecules and its Electrons Density of States by Dft

National Conference on Recent Trends and Developments in Environmental and Basic Sciences (RTDEBS-2018) Organized by, Faculty of Science In collaboration with Internal Quality Assurance Cell (IQAC), Dr. S. D. D. Arts College & Commerce & Science College, Maharashtra, India. Association with International Journal of Scientific Research in Science and Technology © 2018 IJSRST | Volume 4 | Issue 3 | Print ISSN: 2395-6011 | Online ISSN: 2395-602X
High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells

Aldosterone synthase is the key rate‐limiting enzyme in adrenal aldosterone production, and induction of its gene (CYP11B2) results in the progression of hypertension. As hypertension is a frequent complication among patients with diabetes, we set out to elucidate the link between diabetes mellitus and hypertension. We examined the effects of high glucose on CYP11B2 expression and aldosterone production using human adrenal H295R cells and a stable H295R cell line expressing a CYP11B2 5′‐flanking region/luciferase cDNA chimeric construct. d‐glucose (d‐glu), but not its enantiomer l‐glucose, dose dependently induced CYP11B2 transcription and mRNA expression. A high concentration (450 mg·dL−1) of d‐glu time dependently induced CYP11B2 transcription and mRNA expression. Moreover, high glucose stimulated secretion of aldosterone into the media. Transient transfection studies using deletion mutants/nerve growth factor‐induced clone B (NGFIB) response element 1 (NBRE‐1) point mutant of CYP11B2 5′‐flanking region revealed that the NBRE‐1 element, known to be activated by transcription factors NGFIB and NURR1, was responsible for the high glucose‐mediated effect. High glucose also induced the mRNA expression of these transcription factors, especially that of NURR1, but NURR1 knockdown using its siRNA did not affect high glucose‐induced CYP11B2 mRNA expression. Taken together, it is speculated that high glucose may induce CYP11B2 transcription via the NBRE‐1 element in its 5′‐flanking region, resulting in the increase in aldosterone production although high glucose‐induced NURR1 is not directly involved in the effect. Additionally, glucose metabolism and calcium channels were found to be involved in the high glucose effect. Our observations suggest one possible explanation for the high incidence of hypertension in patients with diabetes.
Synthesis and antitumor activity of peptide‐paclitaxel conjugates

Paclitaxel (Pac) is the most important anticancer drug used mainly in treatment of breast, lung, and ovarian cancer and is being investigated for use as a single agent for treatment of lung cancer, advanced head and neck cancers, and adenocarcinomas of the upper gastrointestinal tract. In this work, we present the synthesis of five 2′‐paclitaxel‐substituted analogs in which paclitaxel was covalently bound to peptides or as multiple copies to synthetic carriers. Ac‐Cys(CH2CO‐2′‐Pac)‐Arg‐Gly‐Asp‐Arg‐NH2, Folyl‐Cys(CH2CO‐2′‐Pac)‐Arg‐Gly‐Asp‐Ser‐NH2, Ac‐[Lys‐Aib‐Cys(CH2CO‐2′‐Pac)]2‐NH2, Ac‐[Lys‐Aib‐Cys(CH2CO‐2′‐Pac)]3‐NH2 and Ac‐[Lys‐Aib‐Cys(CH2CO‐2′‐Pac)]4‐NH2 were synthesized using 2′‐halogeno‐acetylated paclitaxel derivatives. Paclitaxel conjugates showed greater solubility in water than paclitaxel and inhibited the proliferation of human breast, prostate, and cervical cancer cell lines. Although all synthesized compounds had an antiproliferative activity, the Ac‐[Lys‐Aib‐Cys(CH2CO‐2′‐Pac)]4‐NH2 derivative showed improved biological activity in comparison with paclitaxel in cervical and prostate human cancer cells. Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd.