Miracle-dz/UniFAR-FTUs huggingface dataset:
A novel SIMD DSP architecture for software defined radio

In this paper, a new DSP architecture for baseband processing in multistandard software-defined radios, is presented. Very high data throughput is achieved by means of massively parallel arithmetic units. The single-instruction multiple-data (SIMD) architecture provides best support for vector-oriented algorithms commonly used in many signal processing applications. Based on a radix-4 butterfly structure and optimized for complex-valued arithmetic, the processor's datapath enables extremely fast FFT computations. Furthermore, exceptional programming flexibility and increased code efficiency are offered by a reconfigurable instruction set. Initial performance assessments have shown remarkable speedup factors for various DSP algorithms in comparison with conventional DSP architectures.
Patient Reported Determinants of Health: A Qualitative Analysis of Veterans with Chronic Obstructive Pulmonary Disease

Abstract Although COPD is a common disorder of veterans who receive care from the Veterans Healthcare Administration (VHA), the perceptions of veterans with COPD about their disease, its effects on their lives, and their interactions with the VHA have not been determined. Utilizing qualitative methodology, we conducted focus groups of veterans with COPD at the Cincinnati VA Medical Center. Participants were selected by systematic sampling from the top quintile of veterans stratified by the cost of healthcare utilization related to a primary diagnosis of COPD and grouped by age and use of supplemental oxygen. All 42 participants were male and had a mean age of 65 years. Analysis of the focus group transcripts demonstrated five major themes: 1) Physical and Functional Limitations: work and employment constraints, recreation restrictions, limits on activities of daily living, reduced sexuality, concerns about housing and finances, and physical symptoms; 2) Restricted Social Interactions/Altered Social Networks: altered relationships with friends and family and reliance upon family and care givers; 3) Emotional Effects: reduced self-worth, vulnerability, depression, perseverance and adaptation, hopelessness, fear, pride, and lack of control; 4) Limitations in the Understanding of COPD: unawareness of diagnosis, triggers and reaction to disease manifestations, COPD management; and 5) Complex Healthcare Interactions. COPD pervasively and extensively affects all aspects of veterans’ lives and causes significant consequences for their care and management.
Lifetime Influences for Cannabis Cessation in Male Incarcerated Indigenous Australians

Abstract Introduction: Urban non-indigenous populations report life events (marriages, employment) as influences for self-initiated cannabis cessation. However, this hasn’t been investigated in remote indigenous populations with different social paradigms. Methods: We investigate cannabis use, harms, and poly-substance misuse in 101 consenting male incarcerated indigenous Australians. Interviews applied quantitative and qualitative questions assessing demographic characteristics, criminal history, drug use, the Marijuana Problems Inventory (MPI), and cannabis-cessation influences. Comparisons used Chi Square, Analysis of Variance, and Nvivo software. Results: Cannabis use groups (current users, ex-users, and never users) were demographically similar except that current users reported more juvenile legal problems, younger school departure, and lower school achievement (p < 0.05). Mean cannabis consumption was 12.3 cones/day. Incarceration and family responsibilities were the strongest cessation influences. Employment responsibilities and negative self-image were rarely cited as influences. Discussion: High cannabis use, with its associated problems, is concerning. These identified influences indicate incarceration should be used for substance reduction programs, plus post-release follow-up. Community-based programs focusing on positive influences, such as family responsibilities and social cohesion, may be successful within indigenous populations with strong kinship responsibilities, rather than programs that focus solely on substance harms.
Overexpression of a constitutively active form of c‐src in skin epidermis increases sensitivity to tumor promotion by 12‐O‐tetradecanoylphorbol‐13‐acetate

Transgenic mice were developed to study the role of c‐src in epithelial tumorigenesis through targeted expression of a constitutively active form of murine c‐src (src529). Src529 was targeted to the interfollicular epidermis with the human keratin 1 (HK1) promoter. The skin phenotype of these mice was characterized by exaggerated epidermal hyperplasia and hyperkeratosis within the first week after birth. The severity of this phenotype correlated with overall src kinase activity, both of which subsided with age. Treatment of adult HK1.src529 transgenic mice with the phorbol ester tumor promoter 12‐O‐tetradecanoylphorbol‐13‐acetate resulted in an increase in epidermal hyperplasia and labeling index significantly greater than that seen in nontransgenic littermates. In addition, HK1.src529 transgenic mice developed papillomas earlier and in significantly greater numbers compared with nontransgenic littermates in a standard initiation‐promotion experiment. The data support the hypothesis that activation of c‐src kinase plays a role in skin tumor promotion. © 2002 Wiley‐Liss, Inc.
Stable H °°Controller Design for the Longitudinal Dynamics of an Aircraft

This report discusses different approaches to stable H °° controller design applied to the problem of augmenting the longitudinal dynamics of an aircraft. Stability of the H c° controller is investigated by analyzing the effects of changes in the performance index weights, and modifications in the measured outputs. The existerLce of a stable suboptimal controller is also investigated. It is shown that this is equivalent to finding a stable controller, whose infinity norm is less than a specified bound, for an unstable plant which is determined from parametrization of all H °° controllers. Examples are given for a gust alleviation and a command tracking problems. _This work was performed while the first author was a NASA/OAI Summer Faculty Fellow at NASA Lewis Research Center.
Genetic Diversity and Population structure of Chinese Panax japonicus

To detect the genetic divergence of Chinese Panax japonicus for its conservation, the population structure of P. japonicus among 12 wild populations of 6 provinces (Hubei, Hunan, Sichuan, Guizhou, Guangxi, and Yunan) were evaluated by using ISSR markers. Estimation of genetic parameters of P. japonicus populations showed that Guizhou and Yunan populations exhibited relatively higher levels of genetic diversity than others. The cluster analysis showed that most Sichuan populations formed a main cluster, whereas populations of other 5 provinces formed 4 discrete clusters. The STRUCTURE and PCA analyses demonstrated that all 12 populations were divided into 4 groups. Populations from Guangxi and Guizhou were gathered into a single group, which indicated their stronger relatedness. The extent of genetic variations and populations divergence of P. japonicus revealed in this study provide a better understanding of evolutionary processes and local adaption of P. japonicus in China, which is significant for further investigations on Panax species for regional conservation and pharmaceutical use.
Connoisseur Consumers, Dynamics Capabilities and Sustainability of Indonesian Single Origin Coffee Consumption

Sustainable consumption became the community’s attention as the respond of worrying consumption growth direction that tends to excessively exploit nature without considering the continuity of the next generation. Take into account the growing coffee consumption in Indonesia, this article tries to prove whether the connoisseur consumers (CCs) are capable to mediate dynamics capabilities (DCs) of single origin coffee shops (SOCSs) and to encourage the consumption sustainability. In-depth interview to 30 SOCS managers, 60 baristas and 450 consumers, it is found that CCs are capable of supporting the business continuity of SOCSs because they are loyal consumers with the contribution of more than 20% from the total consumers. Correlation testing between connoisseurs’ attributes and the number of visits also shows positive value. It means there is a significant relationship. In addition, related to the sustainability attribute, the existence of CCs has encouraged the practice of consumption sustainability. At the same time, CCs are capable to moderate SOCSs to improve sensing, seizing, and transforming shop management to put up with the competition. Based on the above findings, CCs are moderating SOCSs in improving their DCs to be more potential in improving the sustainable consumption of coffee commodity in the future.
Prioritization of lineare TV sub traffic in the IPTV over IMS session

The distribution of real-time ‘linear’ TV, VoD and PvR traffic, on IP infrastructure, requires strict QoS constraints especially low loss and latency of packets transmission. The main challenge to realize these objectives is how to design cross layer architecture which resolve many problems and failures in existing network, and develop a framework intended for control and improve QoS parameters in multimedia service for NGN. Improve these parameters for both wired and wireless network is up to convey these traffics in a convergence platform such as IMS. The aim of this paper is the investigation of the quality of Service (QoS) techniques For IPTV in IMS network by evaluation of video traffic parameters, then we propose a solution which is based on awareness of DiffServ routers to support the new values of the DSCP field assigned to the IPTV also the correct behavior in such a way as to classify BC (Broadcast), VoD (video on demand), PVR (personal video recorder) packets belonging to the same flows and to prioritize the BC ones
Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases

Brain metastases are a serious obstacle in the treatment of patients with human epidermal growth factor receptor-2 (HER2)–amplified breast cancer. Although extracranial disease is controlled with HER2 inhibitors in the majority of patients, brain metastases often develop. Because these brain metastases do not respond to therapy, they are frequently the reason for treatment failure. We developed a mouse model of HER2-amplified breast cancer brain metastasis using an orthotopic xenograft of BT474 cells. As seen in patients, the HER2 inhibitors trastuzumab and lapatinib controlled tumor progression in the breast but failed to contain tumor growth in the brain. We observed that the combination of a HER2 inhibitor with an anti–VEGF receptor-2 (VEGFR2) antibody significantly slows tumor growth in the brain, resulting in a striking survival benefit. This benefit appears largely due to an enhanced antiangiogenic effect: Combination therapy reduced both the total and functional microvascular density in the brain xenografts. In addition, the combination therapy led to a marked increase in necrosis of the brain lesions. Moreover, we observed even better antitumor activity after combining both trastuzumab and lapatinib with the anti-VEGFR2 antibody. This triple-drug combination prolonged the median overall survival fivefold compared with the control-treated group and twofold compared with either two-drug regimen. These findings support the clinical development of this three-drug regimen for the treatment of HER2-amplified breast cancer brain metastases.
Sound Deductive Compilation

Compiler verification is difficult and expensive. Instead of formally verifying a compiler, we introduce a sound deductive compilation approach, whereby verified bytecode is generated based on symbolic execution of source code embedded in a program logic. The program logic guarantees a weak bisimulation relation between the generated bytecode and the original source code relative to a set of observable locations. The framework is instantiated for Java source and bytecode. The compilation process is fully automatic and first-order solvers are employed for bytecode optimization.
Performance Characterization of AOA Geolocation Systems Using the Von Mises Distribution

Circular (angular) random variables, such as the angle of arrival(AOA) in direction finding systems and the phase error in digital phase-locked loops and digital phase interferometers, are best modeled by the von Mises distribution, not the ubiquitous Gaussian distribution. However, the Gaussian distribution has been commonly preferred in the performance analysis of AOA geolocation systems, mostly due to its mathematical tractability. This paper demonstrates the use of the von Mises distribution to model AOA measurement errors in direction finding systems and derives simple expressions for the Fisher information matrix (FIM) and the Cramer-Rao lower bound for the average miss distance. These results show that the use of the von Mises model in the performance analysis of AOA geolocation systems is entirely practicable.
Model Embedding dimension : 400-1000 Hidden layer dimension

Since the first online demonstration of Neural Machine Translation (NMT) by LISA (Bahdanau et al., 2014), NMT development has recently moved from laboratory to production systems as demonstrated by several entities announcing rollout of NMT engines to replace their existing technologies. NMT systems have a large number of training configurations and the training process of such systems is usually very long, often a few weeks, so role of experimentation is critical and important to share. In this work, we present our approach to productionready systems simultaneously with release of online demonstrators covering a large variety of languages (12 languages, for 32 language pairs). We explore different practical choices: an efficient and evolutive open-source framework; data preparation; network architecture; additional implemented features; tuning for production; etc. We discuss about evaluation methodology, present our first findings and we finally outline further work. Our ultimate goal is to share our expertise to build competitive production systems for ”generic” translation. We aim at contributing to set up a collaborative framework to speed-up adoption of the technology, foster further research efforts and enable the delivery and adoption to/by industry of use-case specific engines integrated in real production workflows. Mastering of the technology would allow us to build translation engines suited for particular needs, outperforming current simplest/uniform systems.
An Event-Driven Multiple Objects Surveillance System 35

Traditional surveillance systems are constrained because of a fixed and preset pattern of monitoring. It can reduce the reliability of the system and cause an increased generation of false alarms. It results in an increased processing activity of the system, which causes an augmented consumption of system resources and power. Within this framework, a human surveillance system is proposed based on the event-driven awakening and self-organization principle. The proposed system overcomes these downsides up to a certain level. It is achieved by intelligently merging an assembly of sensors with two cameras, actuators, a lighting module and cost-effective embedded processors. With the exception of low-power event detectors, all other system modules remain in the sleep mode. These modules are activated only upon detection of an event and as a function of the sensing environment condition. It reduces power consumption and processing activity of the proposed system. An effective combination of a sensor assembly and a robust classifier suppresses generation of false alarms and improves system reliability. An experimental setup is realized in order to verify the functionality of the proposed system. Results confirm proper functionality of the implemented system. A 62.3-fold system memory utilization and bandwidth consumption reduction compared to traditional counterparts is achieved, i.e. a result of the proposed system self-organization and event-driven awakening features. It confirms that the proposed system outperforms its classical counterparts in terms of processing activity, power consumption and usage of resources.
High-Gain Regime : 1 D 1

We discuss the free-electron laser physics in high-gain regime in 1D regime, which contains the most important aspects of the free-electron laser dynamics. The high-gain regime is particularly important when mirrors are not available to build oscillators, and has been used as the most straightforward way to produce intense X-rays from FELs.
Extended Neurosphere Culture of Brain Tumor Stem Cells with the PromoCell

While adherent cultures of brain tumor cells in fetal calf serum-containing standard media undergo changes in the form of partial differentiation, 3D cultures of brain cancer cells as neurospheres in serum-free conditions maintain – and therefore reflect better – the properties of primary tumors [1]. However, conventional serum-free media for 3D culturing of neural cancer stem cells as neurospheres struggle to efficiently maintain self-renewing driver subpopulations of cancer stem cells (CSCs). Consequently, the stem cell population in the culture is gradually lost along with its proliferation potential (see Fig. 1, grey chart). The PromoCell 3D Tumorsphere Medium XF is designed to meet your requirements for undifferentiated and extended serial 3D neurosphere culture of most commonly used brain tumor cell lines. Its advanced and defined formulation permits 3D expansion as self-renewing neurospheres while maintaining rigorous cellular selection for stem cell traits, i.e. self-renewal and anoikis resistance. This results in an optimal culture environment for brain CSCs, as is reflected in the sustained serial passage ability of 3D neurospheres with the 3D Tumorsphere Medium XF. Thus, efficient neurosphere expansion allows to easily access cells enriched for sharing these aforementioned stem cell properties (see Fig 1, red chart). PromoCell’s 3D Tumorsphere Medium XF is defined and ready to use, providing a standardized culture devoid of stimuli of uncharacterized origin. This is a significant benefit in terms of neural stem cells, which are highly responsive stem cells that require a reliable and reproducible control of the self-renewal/differentiation axis. The 3D Tumorsphere Medium XF is suitable for a cost-effective, standardized routine culturing of neural cancer cell lines as neurospheres. In contrast to the limited numbers of passages achieved with conventional serum-free formulations, the 3D Tumorsphere Medium XF supports long-term passageable neurosphere cultures of a broad variety of cell lines.
USA – 2010 ) Progress in Material Handling Research 2010 The Human-Centric Warehouse

In theory and in practice, the objective of warehouse design has long been to meet operational requirements of throughput and service performance at minimum cost. A natural product of this “bottom line” approach has been warehouse buildings and operations ill-suited to the humans who spend their working lives interacting with them. We offer an explanation for the current approach, and argue that a new approach— a new paradigm —is needed. We then describe a comprehensive approach to warehouse design that includes human well-being as a primary goal.
Regions of Differences Encoded Antigens as Targets for Immunodiagnosis of Tuberculosis in Humans

Tuberculosis is one of the major global health problems causing nearly 2 million deaths every year. It continues to be a leading cause of morbidity and mortality in developing countries. Accurate early diagnosis and proper treatment can control the spread of tuberculosis in the community. Currently used diagnostic tests have certain limitations such as low sensitivity and suboptimal turn‐around times. Hence, introduction of diagnostic methods that are comparatively more sensitive and specific can increase the efficiency of strategies to control tuberculosis. In recent years, there has been a remarkable progress in identifying new and potentially useful antigens for diagnosis of both latent and active tuberculosis. Regions of differences (RD) encoded proteins are among such promising candidate antigens (RD antigens). Some of these antigens are encoded by regions of differences located in the genome of Mycobacterium tuberculosis, M. africanum, M. bovis but are absent in all the Bacillus Calmette Guerin substrains and many of the environmental mycobacteria. Over the past few years, RD antigens, particularly RD‐based diagnostic methods such as improved tuberculin skin testing, interferon‐gamma release assays, and RD1‐based serological assays are being tested and have shown promising results. This article provides an overview of the use of RD antigens in the immunodiagnosis of tuberculosis infection and disease.
Transcription of the constitutively expressed yeast enolase gene ENO1 is mediated by positive and negative cis-acting regulatory sequences

There are two enolase genes, ENO1 and ENO2, per haploid yeast genome. Expression of the ENO1 gene is quantitatively similar in cells grown on glucose or gluconeogenic carbon sources. In contrast, ENO2 expression is induced more than 20-fold in cells grown on glucose as the carbon source. cis-Acting regulatory sequences were mapped within the 5'-flanking region of the constitutively expressed yeast enolase gene ENO1. A complex positive regulatory region was located 445 base pairs (bp) upstream from the transcriptional initiation site which was required for ENO1 expression in cells grown on glycolytic or gluconeogenic carbon sources. A negative regulatory region was located 160 bp upstream from the transcriptional initiation site. Sequences required for the function of this negative regulatory element were mapped to a 38-bp region. Deletion of all or a portion of these latter sequences permitted glucose-dependent induction of ENO1 expression that was quantitatively similar to that of the glucose-inducible ENO2 gene. The negative regulatory element therefore prevents glucose-dependent induction of the ENO1 gene. Hybrid 5'-flanking regions were constructed which contained the upstream regulatory sequences of one enolase gene fused at a site upstream from the TATAAA box in the other enolase gene. Analysis of the expression of enolase genes containing these hybrid 5'-flanking region showed that the positive regulatory regions of ENO1 and ENO2 were functionally similar, as were the regions extending from the TATAAA boxes to the initiation codons. Based on these studies, we conclude that the negative regulatory element plays the critical role in maintaining the constitutive expression of the ENO1 structural gene in cells grown on glucose or gluconeogenic carbon sources.