Miracle-dz/UniFAR-FTUs huggingface dataset:
Procedural Memory Consolidation in Attention-Deficit/Hyperactivity Disorder Is Promoted by Scheduling of Practice to Evening Hours

In young adults without attention-deficit/hyperactivity disorder (ADHD) training on a novel movement sequence results not only in large within-session (online) gains in task performance but also in additional (delayed, off-line) gains in the performance, expressed after an interval of sleep. In contrast, young people with ADHD, given an identical practice, were shown to improve online but expressed much smaller delayed gains overnight. As delayed gains in performance are taken to reflect procedural (“how to”) memory consolidation processes, this may explain skill learning deficits in persons with ADHD. However, motor training is usually provided in morning sessions, and, given that persons with ADHD are often evening types, chronobiological constraints may constitute a hidden factor. Here, we tested the hypothesis that evening training, compared to morning training, would result in larger overnight consolidation gains following practice on a novel motor task in young women with ADHD. Participants with (N = 25) and without (N = 24) ADHD were given training on a finger opposition sequence tapping task, either in the morning or at evening. Performance was assessed before and immediately after training, overnight, and at 2 weeks post-training. Individuals with ADHD reported a general preference for evening hours. Evening training was equally effective in participants with and without ADHD, both groups showing robust consolidation gains in task performance overnight. However, the ability to express delayed gains overnight was significantly reduced in participants with ADHD if trained in the morning. Typical peers were as effective in expressing overnight consolidation phase gains irrespective of the time-of-day wherein the training session was afforded. Nevertheless, even after morning training, participants with ADHD fully retained the gains acquired within the first 24 h over an interval of about 2 weeks. Our results suggest that procedural memory consolidation processes are extant and effective in ADHD, but require that specific biobehavioral conditions be met. The affordance of training in the evening hours can relax some of the constraints on these processes in ADHD. The current results are in line with the notion that the control of what is to be retained in procedural memory is atypical or more stringent in ADHD.
Dynamic knobs: shape change as a means of interaction on a mobile phone

In this paper, we introduce the change of a mobile phone's hardware shape as a means of tactile interaction. The alteration of shape is implemented in a hardware prototype using a dynamic knob as an interaction device for the user. The knob alters the phone's shape according to different events and states, like incoming calls, new voice mail, or missed calls. Therefore, the user can explore the phone's status by touching it -- ambiently, even through the pocket. Initial user testing showed that this form of tactile interaction was easy to understand and handy to interact with, also for unexperienced users.
Méthodes pour la mise en relations des terminologies médicales : contribution à l'interopérabilité sémantique Inter et Intra terminologique

Depuis une vingtaine d'annees, l'acces et l'utilisation des donnees medicales sont devenus des enjeux majeurs pour les professionnels de sante comme pour le grand public. Dans ce contexte, plusieurs terminologies medicales specialisees ont ete creees. Ces terminologies ont pour la plupart des formats de representation et visees differentes : la nomenclature SNOMED 3. 5 pour le codage d'informations cliniques, les classifications CIM10 et CCAM pour le codage epidemiologique puis medico-economique, le thesaurus MeSH pour la bibliographie. Devant ce constat et la necessite grandissante de permettre la cooperation de differents acteurs de la sante et des systemes d'information associes, il apparait necessaire de rendre les terminologies "interoperables". Notre travail qui s'inscrit dans le cadre du projet ANR InterSTIS (Interoperabilite Semantique des Terminologies dans les Systemes d'informations de Sante Francais), vise a mettre en œuvre des methodes permettant de contribuer a l'interoperabilite entre les differentes terminologies francophones qui seront integrees dans un meme serveur Multi-Terminologique. De plus, nous utilisons nos differents algorithmes conjointement avec le metathesaurus UMLS afin d'apporter une plus grande couverture au niveau des relations entre les terminologies. Nous beneficions, notamment, dans le cadre de cette these, d'une experience riche dans le domaine du Traitement Automatique de la Langue (TAL) issue des precedents travaux de recherche dans les equipes CISMeF et LERTIM.
57Co SPECT, 99mTc-ECD SPECT, MRI and neuropsychological testing in senile dementia of the Alzheimer type

Inflammatory mechanisms contribute to the pathophysiology of senile dementia of the Alzheimer type (sDAT). Previous studies have shown that 57Co single photon emission computed tomography (SPECT) is able to visualize inflammatory lesions, probably by means of the final common pathway of Ca2+ homeostasis disturbance in both neuronal degeneration and inflammation. The aims of this study were: (1) to detect 57Co SPECT changes in sDAT patients; (2) to correlate these findings with those of conventional neuroimaging techniques and neuropsychological testing (NPT); and (3) to compare 57Co SPECT findings in sDAT patients with those in other types of dementia. Six patients suffering from probable sDAT were included and compared with four patients suffering from other types of dementia. All patients had a magnetic resonance imaging (MRI) scan, NPT, 57Co and 99mTc-ethyl cysteinate dimer (ECD) SPECT scan. Perfusion SPECT images were semiquantitatively evaluated by comparison with an age-matched normal database, while 57Co SPECT scans were assessed qualitatively. MRI and 99mTc-ECD SPECT scans yielded conclusive results with regard to the exclusion of other pathologies and the confirmation of the diagnosis. Using visual analysis, 57Co SPECT scans were unable to show any regional raised uptake, irrespective of the disorder, depth or extent of the perfusion defects, presence of atrophy on MRI or the results of NPT.
STATIC OUTPUT FEEDBACK ROBUST CONTROL OF UNCERTAIN LINEAR DISCRETE – TIME SYSTEMS Danica Rosinová

The output feedback robust stabilization problem is studied in this paper for uncertain discrete-time linear system described in state space using polytopic model. The necessary and sufficient conditions for output feedback stabilizability with guaranteed cost are provided as well as the algorithm for computation of output feedback gain matrix. The LMI formulation enables to employ standard efficient computational tools (MATLAB).
Dialect Variation in Stop Consonant Voicing

Recent sociophonetic research has shown significant differences in the pronunciation of vowels among dialects. However, dialectal differences in stop consonant productions have not been as widely researched. This study examines the differences between speakers from south-central/southeastern Wisconsin and westernmost North Carolina, specifically in terms of the way the voiced stop /b/ is produced. Twenty female speakers were selected from recordings, ten from Wisconsin and ten from North Carolina. Each subject read two sets of thirty sentences that included five sets of target words. Acoustic measurements of the consonant /b/ and the target word itself were completed. From these measurements the following variables were calculated: closure duration, word duration, proportion of closure duration to word duration, duration of voicing during closure, proportion of voicing in closure and frequency of complete voicing through closure. The results of these analyses show there are significant differences in the ways the consonant /b/ is produced in Wisconsin and North Carolina. The greatest differences were found in the total duration of voicing during consonant closure, proportion of voicing in closure and the proportion of times the stop closure was completely voiced. The present results provide a comprehensive set of data for a detailed dialect comparison of stop production in these two dialects of American English.
Genes that can bypass the CLN requirement for Saccharomyces cerevisiae cell cycle START

Cell cycle START in Saccharomyces cerevisiae requires at least one of the three CLN genes (CLN1, CLN2, or CLN3). A total of 12 mutations bypassing this requirement were found to be dominant mutations in a single gene that we named BYC1 (for bypass of CLN requirement). We also isolated a plasmid that had cln bypass activity at a low copy number; the gene responsible was distinct from BYC1 and was identical to the recently described BCK2 gene. Strains carrying bck2::ARG4 disruption alleles were fully viable, but bck2::ARG4 completely suppressed the cln bypass activity of BYC1. swi4 and swi6 deletion alleles also efficiently suppressed BYC1 cln bypass activity; Swi4 and Swi6 are components of a transcription factor previously implicated in control of CLN1 and CLN2 expression. bck2::ARG4 was synthetically lethal with cln3 deletion, suggesting that CLN1 and CLN2 cannot function in the simultaneous absence of BCK2 and CLN3; this observation correlates with low expression of CLN1 and CLN2 in bck2 strains deprived of CLN3 function. Thus, factors implicated in CLN1 and CLN2 expression and/or function are also required for BYC1 function in the absence of all three CLN genes; this may suggest the involvement of other targets of Swi4, Swi6, and Bck2 in START.
Robust pictorial structures for x-ray animal skeleton tracking

The detailed understanding of animals in locomotion is a relevant field of research in biology, biomechanics and robotics. To examine the locomotor system of birds in vivo and in a surgically non-invasive manner, high-speed X-ray acquisition is the state of the art. For a biological evaluation, it is crucial to locate relevant anatomical structures of the locomotor system. There is an urgent need for automating this task, as vast amounts of data exist and a manual annotation is extremely time-consuming. We present a biologically motivated skeleton model tracking framework based on a pictorial structure approach which is extended by robust sub-template matching. This combination makes it possible to deal with severe self-occlusions and challenging ambiguities. As opposed to model-driven methods which require a substantial amount of labeled training samples, our approach is entirely data-driven and can easily handle unseen cases. Thus, it is well suited for large scale biological applications at a minimum of manual interaction. We validate the performance of our approach based on 24 real-world X-ray locomotion datasets, and achieve results which are comparable to established methods while clearly outperforming more general approaches.
Robust models for linear programming with uncertain right hand side

We propose new robust models for handling right hand side uncertainty in linear problems. A cutting plane‐like method could be devised to solve the resulting robust problems, but the subproblem to solve at each step involves a bilinear objective. Upper approximations are thus constructed based on linear decision and zero‐order rules on the adjustable variables. Tractable reformulations are given on some uncertainty sets arising in practice. Heuristics are also proposed to compute lower bounds. To assess the methodology we consider its application to the capacity assignment problem. © 2016 Wiley Periodicals, Inc. NETWORKS, Vol. 68(3), 200–211 2016
Evaluation of Shoulder Muscular Fatigue Induced During VDT Tasks

This study was designed to evaluate localized muscular fatigue induced during visual display terminal (VDT) tasks. In the experimental paradigm used, electromyography (EMG) signals were not recorded during the VDT task but during isometric contractions in which the load imposed on the shoulder muscle was kept constant. The change in mean power frequency (MPF) and the root mean square values of EMG signals with time were explored. The correspondence between these measures and the psychological rating of localized muscular fatigue also were examined. The effectiveness of the experimental paradigm and of the measures used for evaluation of localized muscular fatigue are discussed. MPF measured during isometric contraction was found to be a sensitive measure of localized muscular fatigue.
Pandora Meets the NICU Parent or Whither Hope?

Hope is hard to locate when a family gives birth to a baby in need of intensive medical care. Our work in the neonatal unit helps families find a narrative of hope that anchors them as they navigate the shoals of trauma, panic, and depression, allowing them to begin a more normal process of parental preoccupation. This article includes vignettes from experiences with families, some data on prematurity and its effects on mothers, and a discussion of our use of Tavistock-oriented infant observation with the parents. How the neonatal intensive care work has influenced listening with other patients is briefly discussed.
Neurotrophins Induce Death of Hippocampal Neurons via the p75 Receptor

Nerve growth factor (NGF) and related neurotrophins influence neuronal survival and differentiation via interactions with the trk family of receptors. Recent studies have demonstrated that neurotrophins may also induce cell death via the p75 receptor. The importance and generality of neurotrophin-induced death in the brain have not been defined but may play a critical role during development and in disease-associated neuronal death. Here we demonstrate for the first time that all four members of the neurotrophin family directly elicit the death of hippocampal neurons via the p75 receptor. The hippocampus is a complex structure with many different neuronal subpopulations, and signals that influence neuronal death during development may have a critical impact on the mature function of this structure. In these studies we show that each neurotrophin causes the death of hippocampal neurons expressing p75 but lacking the cognate trk receptor. Neurotrophin-induced neuronal death is mediated by activation of Jun kinase. These studies demonstrate that neurotrophins can regulate death as well as survival of CNS neurons.
Enhancing the reach and impact of parenting interventions for toddler externalising and aggressive behaviours

s of studies retrieved and reviewed (n = 176) Ineligible studies, excluded on the basis of title review (n = 3776) Papers selected for full review by two authors (n = 59) Ineligible studies, excluded on the basis of abstract review (n=117) Studies meeting inclusion criteria (n = 6) 53 excluded: •Duration >7 sessions = 41 •Universal intervention = 3 •Multi-component = 5 •Self-directed components = 2 •Not based on social learning theory = 1 •Children with medical condition = 1 assessed reporting of the study (9 items), external validity (3 items), internal validity (10 items) and power (1 item). Each checklist item was scored 0 (no/unable to determine) or 1 (yes) with a maximum possible score of 23. The two reviewers resolved disagreements regarding quality assessment through discussion. Table 1 summarises the abstracted information from the six articles and the Quality Index Score. Where statistical analyses were conducted with MANOVAs, the results in Table 1 include only the findings of the ANOVAs where MANOVAs were significant. Due to the small number of papers identified and significant variations in
Performance evaluation of the reliable cooperative MAC protocol in ad hoc networks

A new reliable cooperative MAC protocol called RCO-MAC is proposed, and the protocol's performance is evaluated with numerical analysis and computer simulation. The key concept for this RCO-MAC protocol is to give the responsibility of the error recovery by retransmission for a frame to the node that transmits the frame. The system throughput is used as a performance metric. According to numerical results, it is shown that the scheme proposed in this paper provides over 20% more system throughput than the rDCF scheme.
Advanced front-end for robust speech recognition in extremely adverse environments

In this paper, a unified approach to speech enhancement, feature extraction and feature normalization for speech recognition in adverse recording conditions is presented. The proposed frontend system consists of several different, independent, processing modules. Each of the algorithms contained in these modules has been independently applied to the problem of speech recognition in noise, significantly improving the recognition rates. In this work, these algorithms are merged in a single front-end and their combined performance is demonstrated. Specifically, the proposed advanced front-end extracts noise-invariant features via the following modules: Wiener filtering, voice-activity detection, robust feature extraction (nonlinear modulation or fractal features), parameter equalization and frame-dropping. The advanced front-end is applied to extremely adverse environments where most feature extraction schemes fail. We show that by combining speech enhancement, robust feature extraction and feature normalization up to a fivefold error rate reduction can be achieved for certain tasks. Index Terms: Speech Recognition, Nonlinear Features, Parameter Equalization, Noise Suppression, Noise Invariant Features
Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling

Many adaptor proteins involved in endocytic cargo transport exhibit additional functions in other cellular processes which may be either related to or independent from their trafficking roles. The endosomal adaptor protein Tollip is an example of such a multitasking regulator, as it participates in trafficking and endosomal sorting of receptors, but also in interleukin/Toll/NF-κB signaling, bacterial entry, autophagic clearance of protein aggregates and regulation of sumoylation. Here we describe another role of Tollip in intracellular signaling. By performing a targeted RNAi screen of soluble endocytic proteins for their additional functions in canonical Wnt signaling, we identified Tollip as a potential negative regulator of this pathway in human cells. Depletion of Tollip potentiates the activity of β-catenin/TCF-dependent transcriptional reporter, while its overproduction inhibits the reporter activity and expression of Wnt target genes. These effects are independent of dynamin-mediated endocytosis, but require the ubiquitin-binding CUE domain of Tollip. In Wnt-stimulated cells, Tollip counteracts the activation of β-catenin and its nuclear accumulation, without affecting its total levels. Additionally, under conditions of ligand-independent signaling, Tollip inhibits the pathway after the stage of β-catenin stabilization, as observed in human cancer cell lines, characterized by constitutive β-catenin activity. Finally, the regulation of Wnt signaling by Tollip occurs also during early embryonic development of zebrafish. In summary, our data identify a novel function of Tollip in regulating the canonical Wnt pathway which is evolutionarily conserved between fish and humans. Tollip-mediated inhibition of Wnt signaling may contribute not only to embryonic development, but also to carcinogenesis. Mechanistically, Tollip can potentially coordinate multiple cellular pathways of trafficking and signaling, possibly by exploiting its ability to interact with ubiquitin and the sumoylation machinery.
A novel locus for pure recessive hereditary spastic paraplegia maps to 10q22.1‐10q24.1

The hereditary spastic paraplegias (HSPs) are a group of clinically and genetically heterogeneous disorders characterized by progressive lower‐limb spasticity. In this study, we performed linkage analysis on an autosomal recessive pure HSP family and mapped the disease to chromosome 10q22.1‐10q24.1, a locus partially overlapping the existing SPG9 locus. We have either identified a novel locus for pure recessive HSP (SPG27), or we have found the first case of allelic disorders with different mode of inheritance in HSP. If the disorders are indeed allelic, our results have reduced the SPG9 interval by 3Mb with D10S536 and D10S1758 as flanking markers. Ann Neurol 2004;56:579–582
Meat Consumption, Cooking Methods, Mutagens, and Risk of Squamous Cell Carcinoma of the Esophagus: A Case-Control Study in Uruguay

The role of meat in squamous cell carcinoma of the esophagus (ESCC) has been considered conflictive. For this reason, we decided to conduct a case-control study on meat consumption and ESCC. Data included 234 newly diagnosed and microscopically examined ESCC and 2,020 controls with conditions not related to tobacco smoking nor alcohol drinking and without changes in their diets. We studied total meat, red meat, beef, lamb, processed meat, poultry, fish, total white meat, liver, fried meat, barbecued meat, boiled meat, heterocyclic amines, nitrosodimethylamine, and benzo[a]pyrene in relation with the risk of ESCC. Red meat, lamb, and boiled meat were directly associated with the risk of ESCC, whereas total white meat, poultry, fish, and liver were mainly protective against this malignancy.
Salvage Treatment of Metastatic Breast Cancer with Docetaxel and Carboplatin

Objectives: To evaluate the efficacy and safety of docetaxel in combination with carboplatin as salvage treatment in women with metastatic breast cancer (MBC). Patients and Methods: Chemotherapy-pretreated women with MBC were treated with docetaxel 75 mg/m2 as 1-hour i.v. infusion followed by carboplatin AUC 6 mg/ml·min, using the Calvert’s formula, as 30-min i.v. infusion. Cycles were repeated on an outpatient basis every 3 weeks. Results: Thirty-six patients received a total of 210 chemotherapy cycles (median 6 cycles/patient). All but one patient had previously received anthracyclines for the treatment of metastatic disease and half of the patients had failed to respond to front-line treatment. Twenty-eight (78%) patients had visceral disease. On an intention-to-treat analysis there were three (8%) complete and 19 (53%) partial responses for an overall response rate of 61% (95% CI: 45.2–77.0%). The response rate was 44% (2 CRs, 6 PRs) among 18 patients who had progressive or stable disease as best response to front-line treatment. The median duration of response was 8 months, the median time to tumor progression 10 months, and the probability of 1-year survival 66%. Grade 3–4 neutropenia was the main hematologic toxicity occurring in 16 (45%) patients or 36 (17%) cycles. Seven (19%) patients developed 8 (4%) febrile neutropenic episodes. Grade 3 thrombocytopenia occurred in 4 (11%) patients or 6 (3%) cycles. Non-hematologic toxicity was generally mild. G-CSF was used in 19 (53%) patients or 134 (64%) cycles. There was one sudden death possibly related to the treatment. Conclusion: The docetaxel-carboplatin combination is an active outpatient salvage regimen for the treatment of women with MBC relapsing or not responding to anthracycline-based front-line therapy.
Dependence and phase changes in random m‐ary search trees

We study the joint asymptotic behavior of the space requirement and the total path length (either summing over all root‐key distances or over all root‐node distances) in random m‐ary search trees. The covariance turns out to exhibit a change of asymptotic behavior: it is essentially linear when 3≤m≤13 , but becomes of higher order when m≥14 . Surprisingly, the corresponding asymptotic correlation coefficient tends to zero when 3≤m≤26 , but is periodically oscillating for larger m, and we also prove asymptotic independence when 3≤m≤26 . Such a less anticipated phenomenon is not exceptional and our results can be extended in two directions: one for more general shape parameters, and the other for other classes of random log‐trees such as fringe‐balanced binary search trees and quadtrees. The methods of proof combine asymptotic transfer for the underlying recurrence relations with the contraction method. © 2016 Wiley Periodicals, Inc. Random Struct. Alg. , 50, 353–379, 2017