Miracle-dz/UniFAR-FTUs huggingface dataset:
Ultra-high performance, low-power, data parallel radar implementations

Radar involves similar operations applied to large amounts of data. It is thus well suited to data parallel (SEMD) hardware. In the past, large data-parallel machines have been applied to radar with limited success. This has been due to such reasons as programming issues, cost, and the hardware being too big for most embedded applications. Most SBVED machines went away a decade ago. There is now a new generation of SIMD COTS technology with powerful processing elements (PEs) and floating-point hardware. WorldScape is applying these chips to radar processing, and has demonstrated significantly more performance with much lower power dissipation (GFLOPS/Watt). These implementations provide attractive alternatives to traditional FPGA and DSP solutions. Lockheed-Martin has provided benchmark validation testing and support for these implementations. The current implementation is based on a 64 PE, 25 GFLOP CS-301 chip supplied by ClearSpeed Technology PLC. WorldScape has demonstrated FFT, Pulse Compression, a form of QR factorization, and other applications on this generation of hardware using a mix of C-level programming and optimized assembly. The next generation chip is compatible, but also has several improvements that will significantly enhance I/O performance as well as raw GFLOP throughput. An updated demonstration and discussion of a scalable processing platform for embedded radar processing which significantly improves I/O performance and provides a roadmap to government-qualified hardware for technology insertion. Architectures, data parallel coding approaches, additional functionality of the scalable processing platform, and relevance to embedded defense radar applications will be discussed.
Vav Proteins in Neutrophils Are Required for FcγR-Mediated Signaling to Rac GTPases and Nicotinamide Adenine Dinucleotide Phosphate Oxidase Component p40(phox)1

Phagocytes generate reactive oxygen species, the regulation of which is important in eliminating ingested microbes while limiting tissue damage. Clustering of FcγRs results in the activation of Vav proteins, Rho/Rac guanine nucleotide exchange factors, and results in robust superoxide generation through the NADPH oxidase. In this study, studies in neutrophils isolated from mice deficient in Vav or Rac isoforms demonstrate a critical role for Vav3 in Rac2-dependent activation of the NADPH oxidase following FcγR clustering. However, studies in cytokine-primed cells revealed a strict requirement for Vav1 and Vav3 and Rac1 and Rac2 in the FcγR-mediated oxidative burst. In comparison, Vav was not essential for PMA or G protein-coupled receptor-mediated superoxide generation. The FcγR-mediated oxidative burst defect in Vav-deficient cells was linked to aberrant Rac activation as well as Rac- and actin-polymerization-independent, but PI3K-dependent, phosphorylation of the NADPH oxidase component p40(phox). In macrophages, Vav regulation of Rac GTPases was required specifically in FcγR-mediated activation of the oxidative burst, but not in phagocytosis. Thus, Vav proteins specifically couple FcγR signaling to NADPH oxidase function through a Rac-dependent as well as an unexpected Rac-independent signal that is proximal to NADPH oxidase activation and does not require actin polymerization.
Pension Funds and the Yield Curve: The Role of Preference for Maturity

What is the effect on the yield curve of an increase in market participation of a large institutional investor? To answer this question, we introduce a simplification of the model with heterogeneity of preference for maturity first proposed by Vayanos and Vila (2009). We show that our simplification entails little loss in fit and interpretation, while it provides greater simplicity and tractability. We take Chilean data of the sovereign fixed income market, and conclude that; for an additional one percent of higher market share of Pension Funds Administrators in said market, interest rates of the 10-year (5-year) associated instruments, are reduced by 6bp (4bp).
Chaperone-mediated autophagy regulates proliferation by targeting RND3 in gastric cancer

ABSTRACT LAMP2A is the key protein of chaperone-mediated autophagy (CMA), downregulation of LAMP2A leads to CMA blockade. CMA activation has been implicated in cancer growth, but the exact mechanisms are unclear. Elevated expression of LAMP2A was found in 8 kinds of tumors (n=747), suggesting that LAMP2A may have an important role in cancer progression. Unsurprisingly, LAMP2A knockdown in gastric cancer (GC) cells hindered proliferation, accompanied with altered expression of cell cycle-related proteins and accumulation of RND3/RhoE. Interactomic and KEGG analysis revealed that RND3 was a putative CMA substrate. Further study demonstrated that RND3 silencing could partly rescue the proliferation arrest induced by LAMP2A knockdown; RND3 was increased upon lysosome inhibition via both chemicals and LAMP2A-shRNA; Furthermore, RND3 could interact with CMA components HSPA8 and LAMP2A, and be engulfed by isolated lysosomes. Thus, constant degradation of RND3 by CMA is required to sustain rapid proliferation of GC cells. At last, the clinical significance of LAMP2A was explored in 593 gastric noncancerous lesions and 173 GC tissues, the results revealed that LAMP2A is a promising biomarker for GC early warning and prognosis of female GC patients.
Modern modified ‘ultra’ Goeckerman therapy: A PASI assessment of a very effective therapy for psoriasis resistant to both prebiologic and biologic therapies

Background: Compared with the original Goeckerman therapy devised by Dr Goeckerman in the 1930s, modern modified Goeckerman therapy in the second millennium shows significantly enhanced efficacy by improvements in technology (e.g. narrowband UVB) and the possibility of adding other relatively safe therapeutic options for more resistant cases to enhance efficacy without compromising the basic safety profile. Methods: For approximately 6 months, psoriasis patients undergoing Goeckerman therapy at the UCSF Psoriasis Center were followed from admission to discharge. A total of 25 consecutive psoriasis patients were treated with the Goeckerman regimen until (near‐) clearance or for a maximum period of 3 months, and their weekly improvements in terms of PASI (psoriasis area and severity index) were recorded. Results: In all, 100% reached PASI 75 by 12 weeks of treatment. In fact, by 8 weeks, 95% reached PASI 75 and most of the patients were discharged within 2 months. Conclusions: The onset of treatment effect was rapid. Goeckerman therapy is still a valuable and important part of the psoriatic armamentarium.
The Specificity of Health-Related Autobiographical Memories in Patients With Somatic Symptom Disorder

Objective Patients with somatic symptom disorder (SSD) have persistent distressing somatic symptoms that are associated with excessive thoughts, feelings, and behaviors. Reduced autobiographical memory specificity (rAMS) is related to a range of emotional disorders and is considered a vulnerability factor for an unfavorable course of pathology. The present study investigated whether the specificity of health-related autobiographical memories is reduced in patients with SSD with medically unexplained dyspnea complaints, compared with healthy controls. Methods Female patients with SSD (n = 30) and matched healthy controls (n = 24) completed a health-related Autobiographical Memory Test, the Beck Depression Inventory, the Ruminative Response Scale, and rumination scales concerning bodily reactions. Depressive symptoms and rumination were assessed because both variables previously showed associations with rAMS. Results Patients with SSD recalled fewer specific (F(1,52) = 13.63, p = . 001) and more categoric (F(1,52) = 7.62, p = . 008) autobiographical memories to health-related cue words than healthy controls. Patients also reported higher levels of depressive symptoms and rumination (all t > 3.00, p < .01). Importantly, the differences in memory specificity were independent of depressive symptoms and trait rumination. Conclusions The present study extends findings on rAMS to a previously unstudied sample of patients with SSD. Importantly, the presence of rAMS could not be explained by increased levels of depressive symptoms and rumination. We submit that rAMS in this group reflects how health-related episodes and associated symptoms are encoded in memory.
Bcl‐2 and Bcl‐x expression in the CD34+ cells of aplastic anaemia patients: relationship with increased apoptosis and upregulation of Fas antigen

Aplastic anaemia (AA) is a syndrome of haemopoietic failure involving increased apoptosis in stem cells. AA CD34+ cells often have upregulated Fas antigen, but this does not explain the increased apoptosis in all patients. To examine whether abnormal expression of the apoptotic modulators Bcl‐2 and Bcl‐x is involved in increased apoptosis in the CD34+ cells of patients, we examined cells from 19 AA patients and 18 normal controls by triple staining for CD34, Bcl‐2 or Bcl‐x, together with 7‐amino actinomycin D to determine viability or with staining for Fas antigen. We confirmed increased apoptosis of CD34+ cells in patients. All CD34+ cells in patients and controls expressed Bcl‐2 and Bcl‐x with no significant difference between the groups. In patients, viability of CD34+/Bcl‐2hi cells was similar to that of CD34+/Bcl‐2lo cells, but CD34+/Bcl‐xhi cells were significantly more viable than CD34+/Bcl‐xlo cells. CD34+ cells from AA patients expressed upregulated Fas antigen, but this did not correlate with Bcl‐2 or Bcl‐x expression. These results suggest a more significant role for Bcl‐x as an anti‐apoptotic regulator in CD34+ cells in AA than Bcl‐2. The induction of death by Fas antigen may bypass the anti‐apoptotic effect of Bcl‐2 and Bcl‐x in CD34+ cells in AA.
The secondary sources method analysis and experimantal modeling of the permanent magnet eddy currents suspansion

The article is devoted to theoretical analysis and experimental modeling of permanent magnet movement above the non-ferromagnetic conductive track. Magnet velocity is considered steady. The theoretical analysis is based on the secondary sources method. This approach requires a numeric system for solving the integro-differential equation with respect to the secondary sources density that is induced in volume and at surface of the track. Among these sources, there are eddy currents and electrical charges. Experimental verification of the calculations was carried out with the model, which is represented by an aluminum cylinder rotating in the field of permanent magnet. Comparison of magnet-track interaction force characteristics obtained with theoretical and experimental methods shows a satisfactorily coincidence. The developed mathematical model can be used for electrodynamic suspended Maglev systems analysis.
MAV stability augmentation using weighted outputs from distributed hair sensor arrays

Insects are known to use a multitude of sensors in flight control and stability; the visuomotor system (compound eye) is the most prominent and has been the subject of extensive study. Trichoid hair sensillae, found extensively on the surface of the head, wings and the thorax of most insects, are used to sense the nature of air flow past the body. Their role and contribution to flight control and stability has not been widely studied. The present work is concerned with the development of a theoretical model that is consistent with previous studies of the sensorimotor architecture and employs the technique of wide-field spatial integration for information processing of hair sensor inputs. These inputs are combined with inputs from the visuomotor system and their impact on planar flight dynamics and stability of a micro helicopter is investigated. The use of hair sensor inputs in conjunction with the optic flow inputs has been found to augment stability and improve performance significantly through a greater degree of decoupling of the vehicle inplane dynamics.
Forkhead box O3 (FOXO3) transcription factor mediates apoptosis in BCG‐infected macrophages

Enhanced apoptosis of BCG‐infected macrophages has been shown to induce stronger dendritic cell‐mediated cross‐priming of T cells, leading to higher protection against tuberculosis (TB). Uncovering host effectors underlying BCG‐induced apoptosis may then prove useful to improve BCG efficacy through priming macrophage apoptosis. Her we report that BCG‐mediated apoptosis of human macrophages relies on FOXO3 transcription factor activation. BCG induced a significant apoptosis of THP1 (TDMs) and human monocytes (MDMs)‐derived macrophages when a high moi was used, as shown by annexin V/7‐AAD staining. BCG‐induced apoptosis was associated with dephosphorylation of the prosurvival activated threonine kinase (Akt) and its target FOXO3. Cell fractionation and immunofluorescence microscopy showed translocation of FOXO3 to the nucleus in BCG‐infected cells, concomitantly with an increase of FOXO3 transcriptional activity. Moreover, FOXO3 expression knock‐down by small interfering RNA (siRNA) partially inhibited the BCG‐induced apoptosis. Finally, real‐time quantitative PCR (qRT‐PCR) analysis of the expression profile of BCG‐infected macrophages showed an upregulation of two pro‐apoptotic targets of FOXO3, NOXA and p53 upregulated modulator of apoptosis (PUMA). Our results thus indicate that FOXO3 plays an important role in BCG‐induced apoptosis of human macrophages and may represent a potential target to improve vaccine efficacy through enhanced apoptosis‐mediated cross‐priming of T cells.
Disparities in HIV transmission risk among HIV-infected black and white men who have sex with men, United States, 2009

Objective:To better understand why HIV incidence is substantially higher among black than white men who have sex with men (MSM), we present the first nationally representative estimates of factors that contribute to transmission – sexual behavior, antiretroviral therapy (ART) use, and viral suppression – among HIV-infected black and white MSM in the United States. Design:The Medical Monitoring Project (MMP) is a complex sample survey of HIV-infected adults receiving medical care in the United States. Methods:We used weighted interview and medical record data collected during June 2009 to May 2010 to estimate the prevalence of sexual behaviors, ART use, and viral suppression among sexually active HIV-infected black and white MSM. We used &khgr;2 tests to assess significant differences between races and logistic regression models to identify factors that mediated the racial differences. Results:Sexual risk behaviors among black and white MSM were similar. Black MSM were significantly less likely than white MSM to take ART (80 vs. 91%) and be durably virally suppressed (48 vs. 69%). Accounting for mediators (e.g. age, insurance, poverty, education, time since diagnosis, and disease stage) reduced, but did not eliminate, disparities in ART use and rendered differences in viral suppression among those on ART insignificant. Conclusion:Lower levels of ART use and viral suppression among HIV-infected black MSM may increase the likelihood of HIV transmission. Addressing the patient-level factors and structural inequalities that contribute to lower levels of ART use and viral suppression among this group will improve clinical outcomes and might reduce racial disparities in HIV incidence.
Teacher reflection: what it is and what it does.

Rigorous research on outcomes of promoting reflection is rare. Moreover, as conceptualizations of reflection depend on underlying philosophies of education, many claims about effects of promoting reflection are questionable. A few research studies do show positive effects on supervisory discourse and journal writing, although school contexts often have a limiting influence. Our own research, which included a longitudinal study, showed effects on the quality of graduates’ interpersonal relationships with students, adequacy of perception of these relationships, and job satisfaction. These were mainly long-term effects. During their first half year of teaching, graduates initially seem to go through a latency period in which the ability to reflect disappears. Moreover, differences in outcomes are related to learning orientations. Students’ learning orientations were investigated by means of the IEO test, which showed correlations between reflective attitude and age, previous schooling and gender. Consequences for teacher education and research are discussed.
Analysis of the expression of a large number of novel genes isolated from mouse prepubertal testis

The analysis of genes expressed in a restricted temporal and spatial manner during spermatogenesis has given insights into different gene‐regulatory mechanisms active in germ cells. However, very few genes have so far been described that are predominantly active in spermatogonia and the early meiotic cell types of testis. To isolate a battery of such genes, more than 100 different mRNA molecules were isolated from a mouse prepubertal testicular cDNA library, and their expression patterns in different tissues analyzed. Thirty mRNAs, 26 of them previously not described in the literature, were found to be predominantly expressed in mouse testis. A detailed analysis of their expression patterns identified a number of mRNA molecules differentially expressed in testicular cell types, including both germ cells and somatic cell types. Characterization of these mRNAs also revealed five distinct temporal phases of gene expression during prepubertal germ cell development. Three different genes, mainly active in the spermatogonial and the early meiotic cell types of testis, were isolated and will be used to characterize further stage‐specific gene expression during germ cell differentiation. © 1992 Wiley‐Liss, Inc.
D2D distance measurement using Kalman filter algorithm for distance-based service in an office environment

The device-to-device (D2D) distance-based service is affected by distance between the D2D devices. Thus, the wireless distance measurement between devices is an indispensable technology in D2D applications. When mobile devices use the distance between D2D devices in the D2D application, the distance should be measured easily and accurately. Several methods can be used to measure the distance between D2D devices. The RSSI system can be used to estimate the D2D distance easily and inexpensively because most D2D devices can estimate the received signal strength. However, estimating the distance using a RSSI is difficult due to inaccuracies. We tested the relationship between distance and a Bluetooth RSSI to look into the inaccuracy of the RSSI in an office environment. Through the results of this test, we realize that the D2D distance is hard to be classified due to the inaccuracy of Bluetooth RSSI. Therefore, filtering algorithm should be applied to reduce the inaccuracy of the Bluetooth RSSI. Nowadays, Kalman filter is widely used in many research fields and shows good performance. Thus, we use the Kalman filter to increase the accuracy of Bluetooth RSSI. To evaluate the effectiveness of the Kalman filter algorithm, we tested the D2D distance measurement in an office environment. The result of this test indicates that the Kalman filter reduces the inaccuracy of Bluetooth RSSI significantly. In addition, we describe wireless body area network (WBAN) region classification using Bluetooth RSSI and Kalman filter in an office environment.
A Dynamic Network Model of the Successor’s Knowledge Construction From the Resource- and Knowledge-Based View of the Family Firm

The article initially addresses the concept of familiness and its connection with the succession process in the family firm to emphasize the relevance of the successor’s knowledge. Then, a model is presented that evolves from a dyadic relationship in the knowledge transfer process from predecessor to successor to a network of exchanges with multiple agents and sources that enhance the successor’s construction of knowledge through time. Key aspects derived from that model about the successor’s human capital, the predecessor’s role, the knowledge network, the relational context, and the time dimension of the process are then discussed.
Sensitivity and Specificity of Various Digit Span Scores in the Detection of Suspect Effort

ABSTRACT Digit Span Age-Corrected Scaled Score (ACSS) and Reliable Digit Span (RDS) have been suggested as effective in assessing credibility. The purpose of this study was to confirm the efficacy of suggested cutoffs for ACSS and RDS and to explore the utility of other Digit Span variables in a large sample (N = 66) of “real-world” ≥ suspect effort patients versus clinic patients with no motive to feign (N = 56) and controls (N = 32). With specificity at ≥ 90%, sensitivity of ACSS increased from 32% to 42% when a ≤ 5 cutoff was used instead of the recommended ≤ 4. The RDS recommended cutoff of ≤ 7 resulted in a sensitivity of 62% but with an unacceptably high false positive rate (23%); dropping the cutoff to ≤ 6 raised the specificity to 93% but sensitivity fell to 45%. Cutoffs for other Digit Span scores did not exceed 45% sensitivity with the exception of 50% sensitivity (11% false positive rate) for average time per digit for all attempted items > 1.0 second. A criterion of ACSS ≤ 5 or RDS ≤ 6 was associated with 51% sensitivity (91% specificity) while RDS ≤ 6 or longest string with at least one item correct ≤ 4 was associated with 54% sensitivity (88% specificity). While only moderately sensitive, Digit Span scores, including new time variables, may have a unique and effective role in the detection of suspect effort.
yucca6, a Dominant Mutation in Arabidopsis, Affects Auxin Accumulation and Auxin-Related Phenotypes1[W][OA]

Auxin plays critical roles in many aspects of plant growth and development. Although a number of auxin biosynthetic pathways have been identified, their overlapping nature has prevented a clear elucidation of auxin biosynthesis. Recently, Arabidopsis (Arabidopsis thaliana) mutants with supernormal auxin phenotypes have been reported. These mutants exhibit hyperactivation of genes belonging to the YUCCA family, encoding putative flavin monooxygenase enzymes that result in increased endogenous auxin levels. Here, we report the discovery of fertile dominant Arabidopsis hypertall1-1D and hypertall1-2D (yucca6-1D, -2D) mutants that exhibit typical auxin overproduction phenotypic alterations, such as epinastic cotyledons, increased apical dominance, and curled leaves. However, unlike other auxin overproduction mutants, yucca6 plants do not display short or hairy root phenotypes and lack morphological changes under dark conditions. In addition, yucca6-1D and yucca6-2D have extremely tall (>1 m) inflorescences with extreme apical dominance and twisted cauline leaves. Microarray analyses revealed that expression of several indole-3-acetic acid-inducible genes, including Aux/IAA, SMALL AUXIN-UP RNA, and GH3, is severalfold higher in yucca6 mutants than in the wild type. Tryptophan (Trp) analog feeding experiments and catalytic activity assays with recombinant YUCCA6 indicate that YUCCA6 is involved in a Trp-dependent auxin biosynthesis pathway. YUCCA6:GREEN FLUORESCENT PROTEIN fusion protein indicates YUCCA6 protein exhibits a nonplastidial subcellular localization in an unidentified intracellular compartment. Taken together, our results identify YUCCA6 as a functional member of the YUCCA family with unique roles in growth and development.