Miracle-dz/UniFAR-FTUs huggingface dataset:
Automatic Classification of Medical Data using Machine Learning

It is evident that usage of machine learning methods in disease diagnosis has been increasing gradually. In this study, we will detect disease like Diabetes using ontology and genetic based machine learning approach. The first is an ontology-based classification that can directly incorporate human knowledge, while the second is geneticbased data mining algorithm that learns or extracts the domain knowledge from medical data in implicit form. The ontological modeling describes the relationship between classes and individuals. The Genetic-based data mining algorithm is a combination of genetic algorithm and machine learning tools for supervised learning which implement different classifiers. It is useful for analyzing the Diabetes disease with the help of symptoms. It is also better to suggest what kind of precautions the patient should take. In this way, these methodologies can be applied to help patients, students and physicians to decide the disease diabetes the patient has, what is the stage of disease and how it can be treated.
A 9.7mW AAC-Decoding, 620mW H.264 720p 60fps Decoding, 8-Core Media Processor with Embedded Forward-Body-Biasing and Power-Gating Circuit in 65nm CMOS Technology

A AAC-decoding, H.264 decoding, media processor with embedded forward-body-biasing and power-gating circuit in CMOS technology is proposed. Since all the components necessary for the scheme are simple MOS circuits requiring no extra supply voltages, they can be placed and routed by a commercial CAD tool. A data-mapping flip-flop was proposed as a high performance and low-power flip-flop. It is concluded that the power dissipation in H.264 720p 60fps decoding of 620mW at the process fast corner is the lowest among the processor-based solutions.
Therapeutic Effects of Mechanical Horseback Riding on Gait and Balance Ability in Stroke Patients

Objective To investigate the therapeutic effects of mechanical horseback riding for gait and balance parameters in post-stroke patients. Method This study was a non randomized prospective positive-controlled trial over a 12 week period. From May 2011 to October 2011, 37 stroke patients were recruited from our outpatient clinic and divided into two groups. The control group received the conventional physiotherapy while the intervention group received the conventional physiotherapy along with mechanical horseback riding therapy for 12 weeks. Outcome measurements of gait included the Functional Ambulation Category (FAC) and gait part of the Performance Oriented Mobility Assessment (G-POMA) while those of balance included the Berg Balance Scale (BBS) and the balance part of the Performance Oriented Mobility Assessment (B-POMA). These measurements were taken before and after treatment. Results There were no significant differences in the baseline characteristics and initial values between the two groups. When comparing baseline and 12 weeks post treatment in each group, the intervention group showed significant improvement on BBS (39.9±5.7 → 45.7±4.8, p=0.001) and B-POMA (10.4±2.6 → 12.6±2.1, p=0.001), but significant improvement on gait parameters. When comparing the groups, the dynamic balance category of BBS in post treatment showed significant difference (p=0.02). Conclusion This study suggests that mechanical horseback riding therapy may be an effective treatment tool for enhancing balance in adults with stroke.
HMM-based speech recognition using adaptive framing

A common approach in mapping a signal to discrete events is to define a set of symbols that correspond to useful acoustic features of the signal over a short constant time interval. This paper proposes a Hidden Markov Models (HMM) based speech recognition by using cepstrum feature of the signal over adaptive time interval. First pitch period is detected by dyadic wavelet transform and divides the voiced speech signal according to the detected period. Then, system performs HMM-based speech recognition using cepstrum feature to classify the speech signals. Two speech recognition systems have been developed, one is based on constant time framing and the other is adaptive framing. The results are compared and found that adaptive framing method shows better result in both data distribution and recognition rate.
Statistical design and analysis of pharmacogenetic trials

Pharmacogenetic trials investigate the effect of genotype on treatment response. When there are two or more treatment groups and two or more genetic groups, investigation of gene–treatment interactions is of key interest. However, calculation of the power to detect such interactions is complicated because this depends not only on the treatment effect size within each genetic group, but also on the number of genetic groups, the size of each genetic group, and the type of genetic effect that is both present and tested for. The scale chosen to measure the magnitude of an interaction can also be problematic, especially for the binary case.
Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease

Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene. Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 cysteine granulin motif. Many cellular processes and diseases are associated with this unique pleiotropic factor that include, but are not limited to, embryogenesis, tumorigenesis, inflammation, wound repair, neurodegeneration and lysosome function. Haploinsufficiency caused by autosomal dominant mutations within the GRN gene leads to frontotemporal lobar degeneration, a progressive neuronal atrophy that presents in patients as frontotemporal dementia. Frontotemporal dementia is an early onset form of dementia, distinct from Alzheimer's disease. The GRN-related form of frontotemporal lobar dementia is a proteinopathy characterized by the appearance of neuronal inclusions containing ubiquitinated and fragmented TDP-43 (encoded by TARDBP). The neurotrophic and neuro-immunomodulatory properties of progranulin have recently been reported but are still not well understood. Gene delivery of GRN in experimental models of Alzheimer's- and Parkinson's-like diseases inhibits phenotype progression. Here we review what is currently known concerning the molecular function and mechanism of action of progranulin in normal physiological and pathophysiological conditions in both in vitro and in vivo models. The potential therapeutic applications of progranulin in treating neurodegenerative diseases are highlighted.
Notch Signalling and the Regulation of Angiogenesis

Angiogenesis, or the formation of new blood vessels from pre-existing ones, is essential to establish the vascular circuit during embryonic development. During angiogenic sprouting, endothelial cells exhibit a diverse array of cellular behaviours. Endothelial tip cells must migrate extensively and proliferate in response to proangiogenic cues while trailing cells need to maintain their position and connection to the patent vasculature, despite exposure to the same proangiogenic molecules. Several new studies have now shed light on the underlying mechanisms that are responsible for coordinating this process. In particular, this work has identified a conserved role for the Notch signalling pathway in limiting the cellular angiogenic response, in part by reducing the level of Vascular endothelial growth factor receptors in endothelial cells. In this overview, we discuss the emerging concepts elucidated by these studies and propose a model in which Notch acts reiteratively throughout the angiogenic process, likely by acting as a switch to determine a cell's response to Vegf.
Social Vehicle Swarms: A Novel Perspective on Social-aware Vehicular Communication Architecture

Internet of vehicles is a promising area related to D2D communication and internet of things. We present a novel perspective for vehicular communications, social vehicle swarms, to study and analyze socially aware internet of vehicles with the assistance of an agent-based model intended to reveal hidden patterns behind superficial data. After discussing its components, namely its agents, environments, and rules, we introduce supportive technology and methods, deep reinforcement learning, privacy preserving data mining and sub-cloud computing, in order to detect the most significant and interesting information for each individual effectively, which is the key desire. Finally, several relevant research topics and challenges are discussed.
Transposition of the gram-positive transposon Tn917 in Escherichia coli

The streptococcal transposon Tn917 was demonstrated to transpose in Escherichia coli from the Bacillus subtilis-E. coli shuttle plasmid pHK1207 into an F' plasmid derivative. Subsequently, a second round of transposition from the F' plasmid into pACYC184 could be readily demonstrated. These results represent the initial demonstration of the transposition of a gram-positive transposon in a gram-negative bacterium at a relatively high frequency.
Analysis and design of an analog control loop for digital input class D amplifiers

Analog input Class D Amplifiers are widely used in battery powered systems such as mobile phones to achieve high efficiency but it suffers from a complex DAC to convert the digital audio signal into an analog one. To increase the playback time, this paper presents digital input class D amplifiers using digital modulation. The proposed Class D amplifier is also controlled using an analog loop to achieve a good power supply immunity and low harmonic distortion. Usual AC analysis of this loop cannot be done due to its switching behavior. Very long transient simulation was the only solution to predict the dynamics performances of the control. To overcome this issue, the presented work includes a modeling method in order to study faster the control performances. The proposed modeling is then used to increase the audio quality reproduction of our digital input Class D amplifier. The complete audio path is implemented in CMOS 130nm process and characterized in order to validate the architecture, the modeling method and the integrated design.
Do Changes in Job Control Predict Differences in Health Status? Results From a Longitudinal National Survey of Canadians

Objective: To examine the effect of changes in job control on health behaviors, psychological distress and health status. Methods: Using a path analysis model, we examined the effects of change in job control over a 4-year period on levels of physical activity, smoking, and psychological distress; and on self-rated health over an additional 2 years, among a representative sample of 2221 Canadians. Results: Over the 4-year period, 280 respondents reported decreases in job control, and 256 reported increases in job control. Health at baseline was not associated with the likelihood of changes in job control. We found a graded relationship between change in job control and levels of physical activity and psychological distress over a 4-year period; and levels of self-rated health over a 6-year period, with positive change in job control associated in higher levels of physical activity and self-rated health and lower levels of distress. Conclusions: The results of this study suggest that both level of job control and changes in job control have direct and indirect effects on health status over time. Future research should focus on developing precise measures of work exposures, and examine differences between changes in job control due to only changes in perceptions and changes due to work redesign. NPHS = National Population Health Survey; SRH = self-rated health.
Estimation of anisotropy coefficient of swine pancreas, liver and muscle at 1064 nm based on goniometric technique

Optical properties of tissues are required for theoretical modeling of Laser Ablation in tumor therapy. The light scattering characteristic of tissues is described by the anisotropy coefficient, g. The relationship between the angular distribution of scattered light and g is given by the Henyey‐Greenstein (HG) phase function.
Molecular weight fibrinogen variants alter gene expression and functional characteristics of human endothelial cells

Summary. Background: Fibrin is a temporary matrix that not only seals a wound, but also provides a temporary matrix structure for invading cells during wound healing. Two naturally occurring fibrinogen variants, high molecular weight (HMW) and low molecular weight (LMW) fibrinogen, display different properties in supporting angiogenesis in vivo and in vitro. Objectives: This study was aimed at investigating the functional characteristics and molecular mechanisms of human microvascular endothelial cells (HMVECs) cultured on HMW and LMW fibrin matrices. Methods and results: HMVECs on HMW fibrin matrices showed increased proliferation and tube formation as compared with their counterparts on unfractionated and LMW fibrin. Degradation of HMW fibrin was markedly enhanced by the presence of HMVECs, that of LMW fibrin was enhanced only slightly. However, the expression levels of fibrinolysis‐regulating proteins and integrins were similar. Subsequent microarray analysis revealed that the expression of 377 genes differed significantly between HMVECs cultured on HMW fibrin and those cultured on LMW fibrin. Among these genes, UNC5B, DLL4 and the DLL4–Notch downstream targets Hey1, Hey2 and Hes1 showed increased expression in HMVECs on LMW fibrin. However, pharmacologic and genetic (DLL4 small interfering RNA) inhibition of DLL4–Notch signaling blunted rather than enhanced proliferation and tube formation by HMVECs on both fibrin variants. Conclusions: Heterogeneity in naturally occurring fibrinogen strongly influences endothelial cell proliferation and tube formation, and causes alterations in gene expression, including that of DLL4–Notch. The higher fibrinolytic sensitivity of HMW fibrin in the presence of HMVECs contributes to increased tube formation. Although the expression of DLL4–Notch was altered, it did not explain the enhanced tube formation in HMW fibrin. This study provides new perspectives for biological and tissue engineering applications.
Significance of micronucleus in the whole spectrum of uterine cervical lesions

Introduction: Cervical cancer is the third most common type of cancer among women worldwide, following breast cancer and colon cancer. The micronucleus test is a simple and widely used technique to evaluate genetic damage due to exposure to carcinogenic or mutagenic agents. We undertook this study to compare the MN (micronucleus) score in the whole spectrum of cervical lesions. Materials and methods: In this retrospective study, we had compared the MN score in the whole spectrum of cervical lesions which comprised of seven different groups like normal (20), inflammatory (30), ASC-US (20), ASC-H (13), LSIL (20), HSIL (10) and IC (19) over a period of 1 year (January 2014 to December 2014) which included a total of 132 cases. Results: In the present study, there was a stepwise gradual increase in MN count from inflammatory to ASC-US to LSIL to HSIL group, followed by a slight increase in IC. The mean MN count was most significant in the LSIL and HSIL group. Thus micronucleated cells as well as the total number of micronuclei show increasing trend towards malignization. Conclusion: Our study showed that MN counting can be a helpful screening tool in conjunction with conventional Pap test for screening of cervical cancer.
Linearly tapered slot antenna array with SIW feed network for 60 GHz applications

In this paper, a linearly tapered slot antenna (LTSA) array fed with a substrate integrated waveguide (SIW) is proposed. An SIW-based 4-way power divider with broadband and low loss properties is designed to implement a compact planar feed network. The array shows a gain of 21 dB with a return loss better than 15 dB over the band of interest (54-66 GHz). The total efficiency of the antenna array is 87 %. The antenna array has a cross polarization level of -22 dB. The proposed array is suitable for 60 GHz short range wireless communications.
Micro-SPECT/CT with 111In-DTPA-Pertuzumab Sensitively Detects Trastuzumab-Mediated HER2 Downregulation and Tumor Response in Athymic Mice Bearing MDA-MB-361 Human Breast Cancer Xenografts

Pertuzumab is a HER2 dimerization inhibitor that binds to an epitope unique from that of trastuzumab. Our objective was to determine whether SPECT with 111In-diethylenetriaminepentaacetic acid–pertuzumab (111In-DTPA-pertuzumab) could sensitively detect an early molecular response to trastuzumab manifested by HER2 downregulation and a later tumor response revealed by a decreased number of HER2-positive viable tumor cells. Methods: Changes in HER2 density in SKBr-3 and MDA-MB-361 BC cells exposed to trastuzumab (14 μg/mL) in vitro were measured by saturation binding assays using 111In-DTPA-pertuzumab and by confocal immunofluorescence microscopy and flow cytometry with fluorescein isothiocyanate–labeled HER2/neu antibodies. Imaging of HER2 downregulation was studied in vivo in athymic mice with subcutaneous MDA-MB-361 tumors treated for 3 d with trastuzumab (4 mg/kg) or nonspecific human IgG (hIgG) or phosphate-buffered saline (PBS). Imaging of tumor response to trastuzumab was studied in mice bearing subcutaneous MDA-MB-361 xenografts treated with trastuzumab (4 mg/kg), followed by weekly doses of nonspecific hIgG or rituximab or PBS (2 mg/kg). Mice were imaged on a micro-SPECT/CT system at 72 h after injection of 111In-DTPA-pertuzumab. Tumor and normal-tissue biodistribution was determined. Results: 111In-DTPA-pertuzumab saturation binding to SKBr-3 and MDA-MB-361 cells was significantly decreased at 72 h after exposure in vitro to trastuzumab (14 μg/mL), compared with untreated controls (62% ± 2%, P < 0.0001; 32% ± 9%, P < 0.0002, respectively). After 3 d of trastuzumab, in vivo tumor uptake of 111In-DTPA-pertuzumab decreased 2-fold in trastuzumab- versus PBS-treated mice (13.5 ± 2.6 percentage injected dose per gram [%ID/g] vs. 28.5 ± 9.1 %ID/g, respectively; P < 0.05). There was also a 2-fold decreased tumor uptake in trastuzumab- versus PBS-treated mice by image volume-of-interest analysis (P = 0.05), suggesting trastuzumab-mediated HER2 downregulation. After 3 wk of trastuzumab, tumor uptake of 111In-DTPA-pertuzumab decreased 4.5-fold, compared with PBS-treated mice (7.6 ± 0.4 vs. 34.6 ± 9.9 %ID/g, respectively; P < 0.001); this decrease was associated with an almost-completed eradication of HER2-positive tumor cells determined immunohistochemically. Conclusion: 111In-DTPA-pertuzumab sensitively imaged HER2 downregulation after 3 d of treatment with trastuzumab and detected a reduction in viable HER2-positive tumor cells after 3 wk of therapy in MDA-MB-361 human breast cancer xenografts.
Interobserver Agreement for Assessing Invasion in Stage 1A Vulvar Squamous Cell Carcinoma

Invasive squamous cell carcinoma of the vulva with ⩽1 mm stromal invasion is classified as stage 1A. Cancer staging systems state that the depth of invasion should be measured from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of the invasive tumor. Measurement of the depth of invasion guides patient management. Even though this measurement is critical, no studies have reported the reliability among pathologists for determining the cutoff point of ⩽1 mm stromal invasion in vulvar cancer. We assessed agreement among pathologists for determining whether a vulvar tumor is invasive, for the depth of invasion, and for tumor thickness. Forty-five cases of vulvar squamous cell carcinoma with a depth of invasion of ⩽5 mm were chosen. Eleven gynecologic pathologists independently reviewed the slides and, for a subset of cases, pictorially recorded measurements on photographs. The number of cases that were reported as invasive by the 11 pathologists ranged from 21 to 44. The number of cases that were reported as showing a depth of invasion of ⩽1 mm ranged from 7 to 27. Eight pathologists provided measurements for all lesions reported as invasive, the remaining 3 pathologists stated that they were unable to measure 2, 7, and 16 lesions, respectively. Mean &kgr; for diagnosing vulvar carcinoma as invasive was 0.24 and for measuring the depth of invasion and thickness was 0.51 and 0.49, respectively. There was only fair agreement in determining whether the lesion was invasive. In cases in which pathologists agreed upon the diagnosis of invasion, agreement on depth was moderate. When using the recommended cancer staging method, interpretation of the location of the most superficial dermal papilla varied among pathologists. Measuring thickness did not improve agreement. This is the first study that has assessed the reliability of the diagnosis of invasion in vulvar cancer among gynecologic pathologists, the interobserver agreement for reporting the critical 1 mm threshold of depth of stromal invasion, and the way in which the International Federation of Gynecology and Obstetrics method is used by pathologists.
Surgical Treatment of Primary Hepatic Epithelioid Hemangioendothelioma

Epithelioid hemangioendothelioma is a very rare tumor of vascular origin. It can develop in different tissues such as soft tissue, lung, or liver. Hepatic epithelioid hemangioendothelioma (HEH) mostly affects females. The malignant potential of HEH often remains unclear in the individual patient. It can range from benign hemangioma to malignant hemangioendotheliosarcoma. Here we present our experience with five patients with primary HEH, who were treated with curative intention in our department. All patients in our series with confirmed histological HEH did not show extrahepatic extension and consequently underwent surgical treatment. In three patients, liver transplantation (LTx) was performed (two cadaveric and one living related). In one patient, a right-sided hemihepatectomy with partial resection of the diaphragm was performed. One patient died while she was on the waiting list for LTx due to rapid tumor progression. Postoperative follow-up ranged from 1 to 13 years. No adjuvant chemotherapy was applied. Until now, no recurrence of local tumor or distant metastases could be observed during follow-up in our series. Early detection and surgical intervention in case of HEH can potentially offer curative treatment. The treatment of first choice appears to be radical liver resection. In our view, LTx represents a potentially important option for patients with a nonresectable tumor. Despite the long waiting time, its often unclear dignity, and a proven progressive growth pattern, living related LTx also plays a potentially important role. The 5-year overall survival rate of patients with HEH in the literature varies from 43% to 55%. Long-term survival of patients with HEH is significantly higher compared to other hepatic malignancies. The role of adjuvant therapy currently remains unclear.