Miracle-dz/UniFAR-FTUs huggingface dataset:
An Eye on Trafficking Genes: Identification of Four Eye Color Mutations in Drosophila

Genes that code for proteins involved in organelle biogenesis and intracellular trafficking produce products that are critical in normal cell function . Conserved orthologs of these are present in most or all eukaryotes, including Drosophila melanogaster. Some of these genes were originally identified as eye color mutants with decreases in both types of pigments found in the fly eye. These criteria were used for identification of such genes, four eye color mutations that are not annotated in the genome sequence: chocolate, maroon, mahogany, and red Malpighian tubules were molecularly mapped and their genome sequences have been evaluated. Mapping was performed using deletion analysis and complementation tests. chocolate is an allele of the VhaAC39-1 gene, which is an ortholog of the Vacuolar H+ ATPase AC39 subunit 1. maroon corresponds to the Vps16A gene and its product is part of the HOPS complex, which participates in transport and organelle fusion. red Malpighian tubule is the CG12207 gene, which encodes a protein of unknown function that includes a LysM domain. mahogany is the CG13646 gene, which is predicted to be an amino acid transporter. The strategy of identifying eye color genes based on perturbations in quantities of both types of eye color pigments has proven useful in identifying proteins involved in trafficking and biogenesis of lysosome-related organelles. Mutants of these genes can form the basis of valuable in vivo models to understand these processes.
Generation of Active Pools of Abscisic Acid Revealed by In Vivo Imaging of Water-Stressed Arabidopsis1

A noninvasive, cell-autonomous reporter system was developed to monitor the generation and distribution of physiologically active pools of abscisic acid (ABA). ABA response (abi1-1) and biosynthesis (aba2-1) mutants of Arabidopsis (Arabidopsis thaliana) were used to validate the system in the presence and absence of water stress. In the absence of water stress, low levels of ABA-dependent reporter activation were observed in the columella cells and quiescent center of the root as well as in the vascular tissues and stomata of cotyledons, suggesting a nonstress-related role for ABA in these cell types. Exposure of seedlings to exogenous ABA resulted in a uniform pattern of reporter expression. In marked contrast, reporter expression in response to drought stress was predominantly confined to the vasculature and stomata. Surprisingly, water stress applied to the root system resulted in the generation of ABA pools in the shoot but not in the root. The analysis of the response dynamics revealed a spread of physiologically active ABA from the vascular tissue into the areoles of the cotyledons. Later, ABA preferentially activated gene expression in guard cells. The primary sites of ABA action identified by in planta imaging corresponded to the sites of ABA biosynthesis, i.e. guard cells and cells associated with vascular veins. Hence, water stress recognized by the root system predominantly results in shoot-localized ABA action that culminates in a focused response in guard cells.
Multimode obstacle-crossing analysis of a wheel/track mobile robot

A transformable wheel-track robot with the tail rod whose winding will coordinate the center of gravity of the robot is studied. First, from the analysis of its crossing obstacle performance, the mechanical structure of the wheel-track robot is designed and the hardware composition of its control system is given. Second, aiming at the functional requirement of climbing up the obstacle, the different track modes including forward climbing procedure and backward climbing procedure during a wheel-track robot's climbing obstacle are studied. Next, based on the analysis to its climbing process, the robot model of climbing obstacle is established by using the classical mechanics method. Through experiments, the effectiveness of the robot model in climbing obstacle is verified, which can provide design and analysis foundations for the mobile robots.
The King-Devick test of rapid number naming for concussion detection: meta-analysis and systematic review of the literature

Background: Vision encompasses a large component of the brain's pathways, yet is not represented in current sideline testing. Objectives: We performed a meta-analysis of published data for a vision-based test of rapid number naming (King-Devick [K-D] test). Studies & methods: Pooled and meta-analysis of 15 studies estimated preseason baseline K-D scores and sensitivity/specificity for identifying concussed versus nonconcussed control athletes. Result: Baseline K-D (n = 1419) showed a weighted estimate of 43.8 s (95% CI: 40.2, 47.5; I2 = 0.0%; p=0.85 – indicating very little heterogeneity). Sensitivity was 86% (96/112 concussed athletes had K-D worsening; 95% CI: 78%, 92%); specificity was 90% (181/202 controls had no worsening; 95% CI: 85%, 93%). Conclusion: Rapid number naming adds to sideline assessment and contributes a critical dimension of vision to sports-related concussion testing.
WORKFLOWS IN CONSTRUCTIONS MODELLED WITH STOCHASTIC ARTIFICIAL SOCIAL SYSTEMS

This paper focuses on evaluation of the performance characteristics of workflows in constructions modeled with stochastic Petri nets (SPN). This goal is achieved by focusing on a new model for Artificial Social Systems (ASS) behaviors. ASS exists in practically every multi-agent system, and play a major role in the performance and effectiveness of the agents. This is the reason why we introduce a more suggestive model for ASS. To model these systems, a class of Petri nets is adopted, and briefly introduced in the paper. This class allows representing the flow of physical resources and control information data of the ASS's components. In the analysis of SPN we use simulations in respect to timing parameters in a generalized semi-Markov process (GSMP). By using existing results on perturbation (e.g., delays in supply with raw materials, derangements of equipments, etc.) analysis and by extending them to new physical interpretations we address unbiased sensitivity estimators correlated with practical solutions in order to attenuate the perturbations. An important advantage of this approach is that one simulation is needed for evaluating the stochastic Petri nets and the perturbation analysis and to take advantage of the state of the art.
IL‐6 Regulates Extracellular Matrix Remodeling Associated With Aortic Dilation in a Fibrillin‐1 Hypomorphic mgR/mgR Mouse Model of Severe Marfan Syndrome

Background Development of thoracic aortic aneurysms is the most significant clinical phenotype in patients with Marfan syndrome. An inflammatory response has been described in advanced stages of the disease. Because the hallmark of vascular inflammation is local interleukin‐6 (IL‐6) secretion, we explored the role of this proinflammatory cytokine in the formation of aortic aneurysms and rupture in hypomorphic fibrillin‐deficient mice (mgR/mgR). Methods and Results MgR/mgR mice developed ascending aortic aneurysms with significant dilation of the ascending aorta by 12 weeks (2.7±0.1 and 1.3±0.1 for mgR/mgR versus wild‐type mice, respectively; P<0.001). IL‐6 signaling was increased in mgR/mgR aortas measured by increases in IL‐6 and SOCS3 mRNA transcripts (P<0.05) and in cytokine secretion of IL‐6, MCP‐1, and GM‐CSF (P<0.05). To investigate the role of IL‐6 signaling, we generated mgR homozygous mice with IL‐6 deficiency (DKO). The extracellular matrix of mgR/mgR mice showed significant disruption of elastin and the presence of dysregulated collagen deposition in the medial‐adventitial border by second harmonic generation multiphoton autofluorescence microscopy. DKO mice exhibited less elastin and collagen degeneration than mgR/mgR mice, which was associated with decreased activity of matrix metalloproteinase‐9 and had significantly reduced aortic dilation (1.0±0.1 versus 1.6±0.2 mm change from baseline, DKO versus mgR/mgR, P<0.05) that did not affect rupture and survival. Conclusion Activation of IL‐6‐STAT3 signaling contributes to aneurysmal dilation in mgR/mgR mice through increased MMP‐9 activity, aggravating extracellular matrix degradation.
PECULIARITIES OF PSYCHOLOGICAL WELL-BEING OF LITTLE TOWN AND METROPOLIS STUDENTS: SOCIOCULTURAL ASPECT

Current social situation unpredictability causes difficulties for modern students in both meeting the requirements of society and keeping their well-being. This study aims at revealing the sociocultural aspect of psychological well-being in Russian little town and metropolis students. The method of “Psychological Well-being Scale”, adapted from the questionnaire “The scales of Psychological Wellbeing” of Ryff, the method of “Personal and Social Identity” of Urbanovich and the Mehrabian Achieving Tendency Scale in modification of Magomed-Eminov were used in this study. The received data indicated that average and low levels of psychological well-being were more characteristic for little town students in case of correlation between their motivation to avoid failure and negative sociocultural identity. These findings seem to be largely resulting from depriving regional conditions and may be considered as an indicator of this deprivation.
Play therapy for multicultural populations: Guidelines for mental health professionals.

This article describes methods and techniques of play therapy for use with multicultural and diverse populations. Barriers to counseling multicultural children and Eurocentric play therapy techniques with multicultural populations are highlighted. Specific guidelines and examples for play therapy with multicultural children are provided. Recommendations and implications for mental health professionals are discussed. The alternative perspectives of children from differing racial and ethnic backgrounds present a challenge to counselors than can no longer be ignored. Today, issues of multicultural differences are encountered on a regular basis. The demographics imperative, or the 'colorization', of the United States by the year 2010 mandates that counselors can no longer be what is referred to as "culturally encapsulated" (Wrenn, 1962). In order to deal more effectively with and understand different cultures, mental health professionals must develop their own cultural identities and become aware of their own biases. This self-awareness, in combination with a commitment to play therapy, must be coupled with effective intervention. This document is copyrighted by the American Psychological Association or one of its allied publishers. This article is intended solely for the personal use of the individual user and is not to be disseminated broadly.
A critical discourse analysis of pavement advertisements of herbal medicine and spiritual healing services in Central Johannesburg

Abstract This article discusses the language in a range of advertisements for herbal medicines and spiritual healing services, as found in fliers distributed on the pavements of the Johannesburg central business district. The socio-cognitive approach to critical discourse analysis (CDA) was employed to analyse the language used. The purpose was to identify the ways in which the producers of the advertisements, through careful choice of discourse, attempt to manipulate potential customers. It was established that the producers purported to have solutions to a broad range of problems affecting society. These included sexual, marital, business-related and social problems, for which the healers claimed to have quick and permanent solutions. Stylistic techniques include the use of juxtaposition, rhetorical questions, hyperbole, punctuation marks, indigenous languages, first-person narratives in testimonies, illustrations and the naming of herbs. The conclusion can be drawn that the advertisements demonstrate a perceived power imbalance between their producers and the target audiences. This may lead certain clients to be deceived by the herbalists and spiritual healers, sometimes with disastrous consequences. It is, however, acknowledged that not everyone in South African society believes all the claims made in these advertisements.
The Roundtable Dialogue of the Initial Construct Validation Study of the Munroe Multicultural Attitude Scale Questionnaire (MASQUE)

Measuring social attitudes on issues that directly affect beliefs, values, and the operative systems of differential and cognitive understanding of the world around us has perplexed researchers and practitioners for centuries (Petty & Wegner, 1998). ). The intent of this research was to develop and examine the construct validity of a multicultural attitude instrument scale. This paper examines the results of the construction of an attitudinal survey on contemporary social issues.
RatLab: an easy to use tool for place code simulations

In this paper we present the RatLab toolkit, a software framework designed to set up and simulate a wide range of studies targeting the encoding of space in rats. It provides open access to our modeling approach to establish place and head direction cells within unknown environments and it offers a set of parameters to allow for the easy construction of a variety of enclosures for a virtual rat as well as controlling its movement pattern over the course of experiments. Once a spatial code is formed RatLab can be used to modify aspects of the enclosure or movement pattern and plot the effect of such modifications on the spatial representation, i.e., place and head direction cell activity. The simulation is based on a hierarchical Slow Feature Analysis (SFA) network that has been shown before to establish a spatial encoding of new environments using visual input data only. RatLab encapsulates such a network, generates the visual training data, and performs all sampling automatically—with each of these stages being further configurable by the user. RatLab was written with the intention to make our SFA model more accessible to the community and to that end features a range of elements to allow for experimentation with the model without the need for specific programming skills.
Finding the Best Feature Detector-Descriptor Combination

Addressing the image correspondence problem by feature matching is a central part of computer vision and 3D inference from images. Consequently, there is a substantial amount of work on evaluating feature detection and feature description methodology. However, the performance of the feature matching is an interplay of both detector and descriptor methodology. Our main contribution is to evaluate the performance of some of the most popular descriptor and detector combinations on the DTU Robot dataset, which is a very large dataset with massive amounts of systematic data aimed at two view matching. The size of the dataset implies that we can also reasonably make deductions about the statistical significance of our results. We conclude, that the MSER and Difference of Gaussian (DoG) detectors with a SIFT or DAISY descriptor are the top performers. This performance is, however, not statistically significantly better than some other methods. As a byproduct of this investigation, we have also tested various DAISY type descriptors, and found that the difference among their performance is statistically insignificant using this dataset. Furthermore, we have not been able to produce results collaborating that using affine invariant feature detectors carries a statistical significant advantage on general scene types.
Consistent Relationship Between the Tunnel Magnetoresistance of CoFeB/MgO/CoFeB Junctions and X-Ray Diffraction Properties

We have investigated the effect of Ar pressure during MgO sputtering on the tunnel magnetoresistance (TMR) and resistance area (RA) product of CoFeB/MgO/CoFeB magnetic tunnel junctions (MTJs). The TMR of MTJs with a thin MgO tunnel barrier deposited at different Ar pressures (1.3, 4, 10, and 25 mTorr) shows a consistent relationship with X-ray diffraction (XRD) properties of thick MgO films deposited with the same conditions. The deposition of the MgO-barrier at 1.3 mTorr results in a low TMR ratio and a high RA product due to the disordered MgO barrier and the oxidation of the bottom electrode of the MTJ, while the deposition at 25 mTorr results in a rough MgO barrier, and thereby gives rise to a large shift of switching field of the free layer due to the orange-peel coupling.
Predicting Obsessive-Compulsive Disorder on the Basis of Emotion Regulation and Anxiety Sensitivity

Article history: Received: 29 Oct 2011 Accepted:23 Nov 2011 Available online: 28 Oct 2012 ZJRMS 2013; 15(2): 94-97 Background: Emotion regulation and anxiety sensitivity are two psychological components which play important roles in causing anxiety disorders. This study aims at predicting the Obsessive-Compulsive Disorder (OCD) based on the emotion regulation and anxiety sensitivity in university students. Materials and Methods: In this descriptive correlation study, a total of 317 students of University of Mohaghegh Ardabili were selected using available sampling method in 2010-2011 academic year and they were asked to fill out the obsessive-compulsive inventories designed for emotion regulation and anxiety sensitivity. Results: The results of regression analysis showed that reappraisal and anxiety sensitivity are the best indicators of OCD in students. Conclusion: The results indicated that the reappraisal and anxiety sensitivity play a significant role in predicting OCD in students.
Log correlation for intrusion detection: a proof of concept

Intrusion detection is an important part of networked-systems security protection. Although commercial products exist, finding intrusions has proven to be a difficult task with limitations under current techniques. Therefore, improved techniques are needed. We argue the need for correlating data among different logs to improve intrusion detection systems accuracy. We show how different attacks are reflected in different logs and argue that some attacks are not evident when a single log is analyzed. We present experimental results using anomaly detection for the virus Yaha. Through the use of data mining tools (RIPPER) and correlation among logs we improve the effectiveness of an intrusion detection system while reducing false positives.
Islamic star patterns from polygons in contact

We present a simple method for rendering Islamic star patterns based on Hankin's "polygons-in-contact" technique. The method builds star patterns from a tiling of the plane and a small number of intuitive parameters. We show how this method can be adapted to construct Islamic designs reminiscent of Huff's parquet deformations. Finally, we introduce a geometric transformation on tilings that expands the range of patterns accessible using our method. This transformation simplifies construction techniques given in previous work, and clarifies previously unexplained relationships between certain classes of star patterns.
Moving Least Squares Coordinates

We propose a new family of barycentric coordinates that have closed‐forms for arbitrary 2D polygons. These coordinates are easy to compute and have linear precision even for open polygons. Not only do these coordinates have linear precision, but we can create coordinates that reproduce polynomials of a set degree m as long as degree m polynomials are specified along the boundary of the polygon. We also show how to extend these coordinates to interpolate derivatives specified on the boundary.
Mechanistic Studies of the Palladium-Catalyzed Copolymerization of Ethylene and α-Olefins with Methyl Acrylate

Mechanistic aspects of palladium-catalyzed insertion copolymerizations of ethylene and α-olefins with methyl acrylate to give high molar mass polymers are described. Complexes [(N∧N)Pd(CH2)3C(O)OMe]BAr‘4 (2) or [(N∧N)Pd(CH3)(L)]BAr‘4 (1: L = OEt2; 3: L ⋮ NCMe; 4: L ⋮ NCAr‘) (N∧N ≡ ArNC(R)−C(R)NAr, e.g., Ar ⋮ 2,6-C6H3(i-Pr)2, R ⋮ H (a), Me (b); Ar‘ ⋮ 3,5-C6H3(CF3)2) with bulky substituted α-diimine ligands were used as catalyst precursors. The copolymers are highly branched, the acrylate comonomer being incorporated predominantly at the ends of branches as −CH2CH2C(O)OMe groups. The effects of reaction conditions and catalyst structure on the copolymerization reaction are rationalized. Low-temperature NMR studies show that migratory insertion in the η2-methyl acrylate (MA) complex [(N∧N)PdMe{H2CCHC(O)OMe}]+ (5) occurs to give initially the 2,1-insertion product [(N∧N)PdCH(CH2CH3)C(O)OMe]+ (6), which rearranges stepwise to yield 2 as the final product upon warming to −20 °C. Activation parameters (ΔH⧧ = .
Ensemble prediction of longitudinal scores of Alzheimer's disease based on ℓ2,1-norm regularized correntropy with spatial-temporal constraint

This paper presents a novel longitudinal framework for clinical score prediction in Alzheimer's disease (AD) diagnosis. In contrast to the previous approaches that use the data collected at a single time point only for the clinical score prediction, we propose to exploit the imaging data of multiple time points. Furthermore, a spatial-temporal group sparse method is proposed for robust feature selection through imposing a fused smoothness term and a locality-preserving-projection based term as well as integrating correntropy into the framework, which is able to promote the prediction consistency and reduce the adverse effect of noises and outliers. Ensemble learning of support vector regression (SVR) is exploited to predict the AD scores more accurately with the selected features. The proposed approach is extensively evaluated on the Alzheimer's disease neuroimaging initiative (ADNI) dataset. The experiments demonstrate that our proposed approach achieves promising regression accuracy.
Two-Level Fractional Guard Channels for Priority Access in Cellular Systems

A two-level fractional guard channels (TLFGC) scheme to efficiently provide priority access for handoff calls over new calls in cellular systems is proposed. The switching between the levels is controlled by a dropped call. The first level has a small number of guard channels like the fixed guard channel (FGC) scheme, while the second level has a larger number of guard channels and a smaller number of fractional guard channels. An analytical formulation of the steady state probabilities, new call blocking probability, handoff call blocking probability, system utilization, probabilities in each level and the equivalent number of guard channels is presented. Numerical results show that the performance of TLFGC is almost the same as a fixed guard channels (FGC) scheme under light load. However, the advantage of the TLFGC scheme is demonstrated under heavy load where the handoff call blocking probability is much better than that of a FGC scheme, giving more priority and protection to handoff calls over new calls
An Object Oriented Approach towards Dynamic Data Flow Analysis

Dynamic data flow analysis is a testing technique that has been successfully used for many procedural programming languages. However, for Object-Oriented (OO) programs, previous investigations have still followed a data-oriented approach to keep track of the state information for various data elements. This paper proposes an OO approach to perform dynamic data flow analysis for OO programs. In this approach, a meta-model of an OO program’s runtime structure is constructed to manage the data flow analysis for the program. An implementation of the model for the Java language is presented, illustrating the practicality and effectiveness of this innovative approach.
Development of a Japanese version of the Reported and Intended Behaviour Scale: Reliability and validity

The Reported and Intended Behaviour Scale (RIBS) was developed in the UK to measure mental health‐related behavior. The current study aimed to evaluate the applicability, and reliability of a Japanese version of the RIBS (RIBS‐J) in a Japanese context, and further examine the construct validity of the RIBS‐J.