Miracle-dz/UniFAR-FTUs huggingface dataset:
Hyperactive hypothalamus, motivated and non‐distractible chronic overeating in ADAR2 transgenic mice

ADAR2 transgenic mice misexpressing the RNA editing enzyme ADAR2 (Adenosine Deaminase that act on RNA) show characteristics of overeating and experience adult onset obesity. Behavioral patterns and brain changes related to a possible addictive overeating in these transgenic mice were explored as transgenic mice display chronic hyperphagia. ADAR2 transgenic mice were assessed in their food preference and motivation to overeat in a competing reward environment with ad lib access to a running wheel and food. Metabolic activity of brain and peripheral tissue were assessed with [18F] fluorodeoxyglucose positron emission tomography (FDG‐PET) and RNA expression of feeding related genes, ADAR2, dopamine and opiate receptors from the hypothalamus and striatum were examined. The results indicate that ADAR2 transgenic mice exhibit, (1) a food preference for diets with higher fat content, (2) significantly increased food intake that is non‐distractible in a competing reward environment, (3) significantly increased messenger RNA (mRNA) expressions of ADAR2, serotonin 2C receptor (5HT2CR), D1, D2 and mu opioid receptors and no change in corticotropin‐releasing hormone mRNAs and significantly reduced ADAR2 protein expression in the hypothalamus, (4) significantly increased D1 receptor and altered bioamines with no change in ADAR2, mu opioid and D2 receptor mRNA expression in the striatum and (5) significantly greater glucose metabolism in the hypothalamus, brain stem, right hippocampus, left and right mid brain regions and suprascapular peripheral tissue than controls. These results suggest that highly motivated and goal‐oriented overeating behaviors of ADAR2 transgenic mice are associated with altered feeding, reward‐related mRNAs and hyperactive brain mesolimbic region.
Entre la création de contenus et l'intelligence territoriale: la dimension éthique

L'internet est ne sous des auspices ambivalentes : il a fait partie d'un projet de l'armee americaine qui a finance ses premiers pas dans les annees 60 tout en etant la concretisation des reves libertaires d'une generation d'etudiants et de scientifiques cherchant a partager leurs connaissances. Ce n'est que bien plus tard, 30 ans apres -une generation ! - que les appetits commerciaux de la societe marchande y ont vu une formidable opportunite de relancer le commerce jusqu'a en faire une bulle qui a fini par eclater. Que reste-t-il de cette extraordinaire aventure des dernieres decennies ? Un media de plus qui est maintenant entre dans les mœurs de la quasi totalite des citoyens du monde occidental.
hydroxyglutarate dehydrogenase of Fusobacterium from human dental plaque was purified by anion-exchange chromatography and its enzymatic properties inves- tigated. Materials and Methods Cell strain and reagents-A strain of Fusobacterium sp. was isolated from human dental plaque with modified FM medi

Although a similar enzyme, glutamate dehydrogenase, which requires ammonium ions and NADH to produce glutamate, has been reported by many researchers[1-7], this enzyme has not been well studied except in Peptococcus aerogenes[6-9]. In order to clarify the correlation between periodontal disease and the 2-hydroxyglutarate dehydrogenase of Fusobacterium, the present study was conducted in which 2hydroxyglutarate dehydrogenase of Fusobacterium from human dental plaque was purified by anion-exchange chromatography and its enzymatic properties investigated.
Rectal, bladder and sexual function after mucosal proctectomy with and without a pelvic reservoir for colitis and polyposis

Sexual, bladder and rectal function have been assessed prospectively in a group of patients undergoing mucosal proctectomy, primarily for ulcerative colitis. The function of the rectum and ‘neo‐rectum’ was studied before and 3 months (on average) after operation in 18 patients. Intestinal continuity was restored by means of ileo‐anal anastomosis; in addition to ileo‐anal anastomosis, a pelvic reservoir (MP + RES) was constructed in 10 patients, while ileo‐anal anastomosis alone (MP + IAA) was used in the remaining 8 patients. Thirteen of these patients have been studied for a minimum of 4 months after closure of the defunctioning ileostomy.
An orange social platform for young people

The high unemployment rate, decreasing salary, and housing pressure, etc. in Taiwan have led to unhappiness and frustration among people. To address this problem, the question our team proposes for exploring a possible technological solution is: “Is every one able to possess eudemonic well-being? ” This study expects to identify a web/mobile-based Orange Technology application that enables the sense of eudemonic well-being of its users. Because happiness (i.e., a subjective measure of eudemonic well-being) is shown to be resulted from being socially connected, such application could be a “social communication and interactive tool” that handles interactions between a pair or group of users. The targeted users are those whose ages fall between the generations X and Y (twenties to forties). The adopted technologies include those for developing web platforms (e.g., web-based programming languages and protocols) and analyzing real time data (e.g., Ensemble Empirical Mode Decomposition, Cross-Correlation, and Relaxed Variable Kernel Density Estimation).
Vascular endothelial growth factor–regulated ovarian cancer invasion and migration involves expression and activation of matrix metalloproteinases

Vascular endothelial growth factor (VEGF) expression is elevated in primary ovarian tumors and metastases. We examined the effect of VEGF on epithelial ovarian cancer (EOC) in vitro invasion and migration and underlying mechanisms. Using the Matrigel invasion assay and colloidal gold phagokinetic track assay, we found that VEGF induced EOC DOV13 invasion and migration in a matrix metalloproteinase (MMP)–dependent manner. Using Western blotting, we show that VEGF, at 20–80 ng/ml, induced secretion of pro‐MMP‐7 and pro‐MMP‐9 and activation of pro‐MMP‐2 in DOV13 conditioned medium in a concentration‐dependent manner. However, gelatinolytic activity and total MMP‐7 protein in DOV13 conditioned medium reached the maximum upon VEGF treatment at 20–40 ng/ml and decreased at higher‐concentration VEGF treatment (80 ng/ml), as shown by DQ‐gelatin degradation assay and ELISA. In addition to the effect on MMP secretion/activation, VEGF stimulated secretion of TIMP‐2; and blocking TIMP‐2 activity by an anti‐TIMP‐2 MAb significantly increased VEGF (80 ng/ml)–induced DOV13 invasion (p < 0.05), suggesting that VEGF may regulate MMP‐2 activity in DOV13 conditioned medium through TIMP‐2. Using real‐time PCR, we found that VEGF, at 20 ng/ml, significantly increased the expression of VEGFR‐1 and VEGFR‐2 by approximately 4‐fold and 31‐fold, respectively, compared to untreated control (p < 0.05). However, the inducing effect of VEGF on VEGFR‐2 expression and the internal expression of VEGF121 in DOV13 cells decreased with increasing of VEGF concentration, suggesting the existence of a negative feedback regulatory mechanism. In summary, our results indicate that VEGF may regulate EOC invasion and migration through VEGFR‐mediated secretion and activation of MMPs. © 2005 Wiley‐Liss, Inc.
A Motion Tracker Using High-Accuracy AR Markers for On-site Motion Analysis

Motion analysis of human body is indispensable for design and evaluation of assistive technologies. Especially, on-site analyses, which are conducted not in experimental environments but in life circumstances, are important to develop truly beneficial assistive technologies. We developed a portable motion tracking system using high-accuracy AR markers. It enables easy measurement of 6-DOF (six degrees of freedom) motion of multiple tracking points by a single camera. The pose estimation errors are about 5 [mm] in location (depth) and about 2 [deg] in orientation. We applied the prototype of the motion tracker to the on-site motion analysis tasks, and demonstrated its availability in the evaluation of assistive technologies.
Harvesting Social Signals to Inform Peace Processes Implementation and Monitoring

Abstract Peace processes are complex, protracted, and contentious involving significant bargaining and compromising among various societal and political stakeholders. In civil war terminations, it is pertinent to measure the pulse of the nation to ensure that the peace process is responsive to citizens' concerns. Social media yields tremendous power as a tool for dialogue, debate, organization, and mobilization, thereby adding more complexity to the peace process. Using Colombia's final peace agreement and national referendum as a case study, we investigate the influence of two important indicators: intergroup polarization and public sentiment toward the peace process. We present a detailed linguistic analysis to detect intergroup polarization and a predictive model that leverages Tweet structure, content, and user-based features to predict public sentiment toward the Colombian peace process. We demonstrate that had proaccord stakeholders leveraged public opinion from social media, the outcome of the Colombian referendum could have been different.
Rotated Half-Mode Substrate Integrated Waveguide

This paper outlines a new variant of a Half-Mode Substrate Integrated Waveguide which enables direct interaction with the wave energy; the rotated Half-Mode SIW. SIW discontinuities are normally vias, but the rHMSIW allows SIW discontinuities to be fabricated directly in copper and hence improved manufacturing tolerances.
IEC qualification test applied to capacitively graded 13.8 kV bar samples energized with repetitive fast pulses

The paper investigates the repetitive fast pulse tests using IEC-TS 60034–18–42 as applied to 13.8 kV bar samples with two different stress grading systems: nonlinear resistive and capacitive. Insulated copper bars were furnished with a capacitive stress grading system consisting of aluminum foils embedded into the groundwall insulation forming a capacitively graded system. The effectiveness of the capacitive stress grading is shown by passing all of the IEC/TS 60034–18–42 qualification tests showing considerably lower temperature rise than resistive stress grading systems.
3D deformable face model for pose determination and face synthesis

This paper describes a scheme for pose determination and face synthesis using a deformable 3D face model. This model is a composite of three sub-models: edge model, color model and a wire frame model (WFM) which jointly describe the shape of the face and various facial features. The edge and color models are used for image analysis and the WFM is used mainly for face synthesis. We can project this 3D model onto different view planes based on three rotational parameters to generate 2D face templates for matching face images. After matching, the pose can be readily estimated. The composite face model is allowed to undergo complex deformation to handle face shape variations among different people. The WFM is incorporated into the model so that after matching, the WFM can be readily adapted to the image and image synthesis can be carried out. This technique can be used to analyze and synthesize face images over a wide range of poses.
Christianity and Classical Culture

subdivisions. The extreme difficulty) however) of discriminating and recordin g all the di fferen t shades of mean i ng) and the cons tan t and inevitable intrusion of the compiler's personal judgment which it implied) forced the abandon men t of the plan. One recogn i'les but cannot help regretti ng the necessity. For the topical index was substituted entry under the most important word, the method of the concordance. This may seem too mechanical, but an index: is a machine; and it has two great advantages: it enables the compiler to indicate something of the context) and the student to run down all passages possibly required and make up his own mind about them. Characteristically Professor Patterson has preferred utility to complete consistency and has added some passages where the idea is present without the actual word. Thus, to illustrate, you will find under the heading Liberty an enormous number of phrases in which the word IS present, and some few where the word is absent but the idea present. The order of the entries is that of occurrence in the Columbia Milum (though the Index can fairly satisfactorily be used with other edi tions). There are no subdivisions, such as ChriJtian HhertYI cioilliberty, religious liberty; but the informed student will be' quick to turn to these adjectives, and he will not be disappoioted. For others a crossreference might profitably have been added. As is proper) the great Index is an lnvitation to study and thought, not a mere laboursaving device. For the gigantic effort) the loving care and the practical good sense that have gone to its making every student of Milton must be profoundly grateful) and in them he may nnd a model and an inspiration.
New Lipoxygenase‐Inhibiting Constituents from Calligonum polygonoides

Calligonolides A (1) and B (2), two new butanolides, and a new steroidal ester, 3, have been isolated from the whole plant of Calligonum polygonoides, together with four known compounds, tetracosan‐4‐olide, β‐sitosterol and its glucoside, and ursolic acid. Their structures were elucidated by spectroscopic and mass‐spectrometric studies. Compounds 1–3 showed moderate inhibitory potential against lipoxygenase from soybean.
Oxygen Metabolism of the HL‐60 Cell Line: Comparison of the Effects of Monocytoid and Neutrophilic Differentiation

HL‐60 cells are promyelocytic leukemia cells that respond to culture conditions with differentiation into granulocytelike or macrophagelike phagocytes. O2 metabolism is critical to the microbicidal function of phagocytic cells. O2 metabolism was studied in HL‐60 cells differentiated with dimethylsulfoxide (Me2SO) and 1,25(OH)2D3, with the objective of 1) determining the validity of these cells as models for human neutrophils and monocytes, respectively, and 2) determining whether these ceils are capable of forming hydroxyl radical. Me2SO‐treated cells had morphology consistent with human neutrophils. O2 consumption by these cells in response to phorbol myristate acetate (PMA; 100 ng/ml) or opsonized zymosan (3 mg/ml) was less than that by neutrophils, as was superoxide formation. O2 metabolism was not inhibited by KCN or antimycin A. Myeloperoxidase (MPO) activity decreased during differentiation but remained greater than that of human neutrophils. Cytochalasin B enhanced recovery of superoxide secreted in response to zymosan, implying its release from the phagosome. 1,25(OH)2D3‐treated cells had morphology consistent with monocytes. O2 consumption and superoxide release were less than with Me2O‐treated cells. Unlike the case with human monocytes, O2 consumption was not inhibited by KCN or antimycin A. MPO activity was minimally reduced by differentiation. Cytochalasin B inhibited recovery of superoxide. Luminol‐dependent luminescence was greater among 1,25(OH)2D3‐treated cells than among Me2SO‐treated cells. Free radicals were also measured with a spin trapping technique using 5,5‐dimethyl‐1‐pyrroline‐N‐oxide (DMPO). Spin trapping allows direct, simultaneous detection of superoxide and hydroxyl radicals. Regardless of the mechanism of differentiation, only superoxide was formed by HL‐60 cells. These results show that Me2SO‐treated HL‐60 cells represent an excellent model for the study of human neutrophil oxidative function. However, 1,25(OH)2D3‐treated cells are quite different in their O2 metabolism from peripheral blood monocytes.
Pattern discovery and similarity assessment for robust Heart Sound Segmentation

Heart Sound Segmentation plays a fundamental role in pathology detection in Phonocardiogram (PCG) signals. This matter of study has been widely studied in the past decades, however the majority of algorithms' results correspond only to small databases, composed by only quality signals or signals specific to one acquisition system. In this work we proposed a robust segmentation algorithm integrated with clinical information, based on a pattern recognition approach for segmentation of the fundamental heart sounds, which is validated in several databases from different countries and with different acquisition instrumentations. The database comprises a total of 3153 recordings from 764 patients with a variety of pathological conditions. The general results were 95% and 96% of sensitivity and positive predictivity, respectively. Based on the results the algorithm is able to perform with accuracy maintaining generalization capabilities.
Detecting Remote Protein Evolutionary and Structural Relationships via String Scoring Method

The amount of information being churned out by the field of biology has jumped manifold and now requires the extensive use of computer techniques for the management of this information. In this work, we propose, an effective learning method for detecting remote protein homology. The proposed method uses a transformation that converts protein domains into fixed-dimensional representative feature vectors, where each feature records the sensitivity of a set of substrings to a previously learned protein domain. These features are then used to compute the kernel matrix that will be used in conjunction with support vector machines. The proposed method is tested and evaluated on two different benchmark protein datasets and it's able to deliver remarkable improvements over most of the existing homology detection methods
Answering for Directional Rules Technical Report 3026 AIFB , Kalrsruhe Institute of Technology

This paper introduces Directional Rules, a new extension of Datalog with existential quantifiers in rule heads in the spirit of formalisms like tuplegenerating dependencies, Datalog+/− and ∀∃-rules that have attracted new interest recently. As opposed to known decidable classes of such existential rules, Directional Rules support complex join conditions as required for expressing transitivity. Nonetheless, the new language suggests surprisingly simple algorithms for answering a broad class of conjunctive queries in polynomial time regarding data complexity. In contrast, answering unrestricted conjunctive queries is undecidable, and we propose further restrictions and more complex algorithms for recovering decidability in the general case. Besides their immediate use for data integration and data exchange, Directional Rules are of particular interest since they can capture large real-world ontologies that could hitherto be modelled in description logics only, even though they are mostly used in database-driven ap-
Adderall XR: long acting stimulant for single daily dosing

Adderall XR (SLI381) is the latest addition to the group of psychostimulant formulations, which provides the mixed amphetamine salts contained in Adderall as a single-daily dose formulation. Adderall XR is indicated for the treatment of attention deficit hyperactivity disorder in children and adolescents, with recent US Food and Drug Administration approval for attention deficit hyperactivity disorder in adults. Novel and important aspects of Adderall XR is its 12 h duration of action, relative superior efficacy to nonstimulant atomoxetine in a comparator trial, and significant quality of life impact in children, confirmed by the largest effectiveness trial yet to be performed for any attention deficit hyperactivity disorder therapy. Potentially important benefits of Adderall XR are proven safety and efficacy in adults with attention deficit hyperactivity disorder and positive postmarketing findings in treating oppositional defiant disorder – the most common comorbidity in children with attention deficit hyperactivity disorder. This review summarizes the important properties of Adderall XR, to include a distinct two-stage delivery system and combination of active ingredients, offering unique advantages. Relevant clinical trials and the newest data from meeting reports are also discussed.
Feasibility of an expressive‐disclosure group intervention for post‐treatment colorectal cancer patients

Adjusting to cancer requires effective cognitive and emotional processing. Written and verbal disclosure facilitate processing and have been studied independently in cancer survivors. Combined written and verbal expression may be more effective than either alone, particularly for patients with difficult to discuss or embarrassing side effects. Thus, the authors developed and tested the efficacy of a 12‐session combined written and verbal expression group program for psychologically distressed colorectal cancer (CRC) patients.
A review of cyclostationary feature detection based spectrum sensing technique in cognitive radio networks

In wireless communications, the transmitted signals show very strong cyclostationary features based on the modulation type, carrier frequency, and data rate, especially when excess bandwidth is utilized. Therefore, identifying the unique set of features of a particular radio signal for a given wireless access system can be used to detect the system based on the cyclostationary analysis at the cognitive radio node. Cyclostationary feature detection based technique has been proposed by many researchers as a key solution for detecting these signals. This paper therefore, took a detail review of the proposals from different authors and pointed out the challenges faced by this method and concluded that it cannot be used to achieve optimality when detecting the presence and absence of primary user. The paper also went further to analyze the principle and model for cyclostationary feature based detection method.
DEMANDA DO SERVIÇO DE SAÚDE DE EMERGÊNCIA: CARACTERÍSTICAS E FATORES DE RISCO PARA O USO INADEQUADO

Objetivo: Avaliar a demanda do servico de saude de emergencia. Metodo: Foi realizada analise descritiva de 1647 individuos adultos que consultaram no servico publico de emergencia de Pelotas, Brasil. Resultados: Pessoas com mais idade, de cor nao branca, menor escolaridade, sem companheiro e tabagistas consultaram mais nesse servico, quando comparados com a populacao em geral. Os individuos esperaram em media 15 minutos pra serem atendidos, foi solicitado exame em mais de 40% dos atendimentos e administrado medicamentos endovenosos em um terco das vezes. Idosos demoraram mais para procurar atendimento, mas foram atendidos mais rapidamente quando chegaram na emergencia, e tiveram mais frequentemente medico definido e suporte social. Tiveram tambem mais diagnosticos relacionados com o aparelho circulatorio, enquanto os mais jovens consultaram mais por causas externas. Conclusao: A baixa media de espera pelo atendimento sugere que este servico presta um atendimento imediato, enquanto a grande quantidade de diagnosticos mal definidos indica que o atendimento e provisorio. E preciso treinar os profissionais da emergencia para reduzir a solicitacao de exames e assegurar que tanto profissional quanto populacao esteja consciente da importância de uma atencao continuada.
Xmrk‐induced melanoma progression is affected by Sdf1 signals through Cxcr7

Chemokine signals mediated by Sdf1/Cxcl12 through the chemokine receptor Cxcr4 are thought to play an instructive role in tumor migration and organ‐specific metastasis. We have used a small aquarium fish model to contribute to a better understanding of how the course of melanoma development is influenced by Sdf1 signals in vivo. We studied oncogene‐induced skin tumor appearance and progression in the transgenic medaka (Oryzias latipes) melanoma model. Similar to humans, invasive medaka melanomas show increased levels of sdf1, cxcr4, and cxcr7 gene expression. Stable transgenic fish lines overexpressing sdf1 exclusively in pigment cells showed a reduction in melanoma appearance and progression. Remarkably, diminished levels of functional Cxcr7, but not of Cxcr4b, resulted in strongly reduced melanoma invasiveness and a repression of melanoma. Our results thereby indicate that Sdf1 signals via Cxcr7 are able to constrain melanoma growth in vivo and that these signals influence tumor outcome.