Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapeutic Roles of Statins in Gynecology and Obstetrics: The Current Evidence

Introduction: Statins are a class of drugs, which act by inhibiting the rate-limiting enzyme of cholesterol biosynthesis (3-hydroxy-3-methyl-glutaryl-CoA reductase). The inhibition of mevalonate synthesis leads to subsequent inhibition of downstream products of this pathway, which explains the pleiotropic effects of these agents in addition to their well-known lipid-lowering effects. Accumulating evidence suggests that statins might be beneficial in various obstetric and gynecologic conditions. Methods: Literature searches were performed in PubMed and EMBASE for articles with content related to statins in obstetrics and gynecology. The findings are hereby reviewed and discussed. Results: Inhibition of mevalonate pathway leads to subsequent inhibition of downstream products such as geranyl pyrophosphate, farnesyl pyrophosphate, and geranylgeranyl pyrophosphate. These products are required for proper intracellular localization of several proteins, which play important roles in signaling pathways by regulating membrane trafficking, motility, proliferation, differentiation, and cytoskeletal organization. The pleiotropic effects of statins can be summarized in 4 categories: antiproliferative, anti-invasive, anti-inflammatory, and antiangiogenic. The growing body of evidence is promising for these agents to be beneficial in endometriosis, polycystic ovary syndrome, adhesion prevention, ovarian cancer, preeclampsia, and antiphospholipid syndrome. Although in vivo studies showed varying degrees of benefit on fibroids and preterm birth, appropriately designed clinical trials are needed to make definitive conclusions. Conclusion: Statins might play a role in the treatment of endometriosis, polycystic ovary syndrome, adhesion prevention, ovarian cancer, preeclampsia, and antiphospholipid syndrome.
The Bias of Communication

One of the most influential books ever published in Canada, Harold A. Innis's The Bias of Communication has played a major part in reshaping our understanding of history, communication, and media theory. First published in 1951, this masterful collection of essays explores the relationship between a society's communication media and that community's ability to maintain control over its development. Innis considers political and economic forces in the context of social change and the role of communication in the creation of both ancient and modern empires. In an essay for this new edition, Innis biographer Alexander John Watson examines the reasons why Innis, at the height of his success as an economic historian, embarked on new research areas of communications and empire, as well as the ways in which Marshall McLuhan's interpretations of Innis changed and de-politicized Innis's work. As important today as it was when first published, The Bias of Communication is essential reading for historians and scholars of communication and media studies.
Cell surface antigens of human malignant melanoma. III. Recognition of autoantibodies with unusual characteristics

The sera of three patients with malignant melanoma showing reactivity with surface antigens of cultured autologous melanoma cells were analyzed by mixed hemadsorption and immune adherence assays in conjunction with absorption tests. In contrast to the melanoma-specific antigens demonstrated previously, the surface antigens detected by these sera occurred on a broad range of nucleated cells, both normal and malignant, from human, monkey, mouse, and chicken sources. Each serum had a characteristic pattern of reactivity in absorption tests, indicating the detection of distinct antigenic systems. Two sera showed auto-, allo-, and xenoreactivity, as well as the capacity to distinguish different cell populations in the same individual. The other serum reacted with an antigen apparently universally present on nucleated cells from a variety of species, but absent on erythrocytes. As these patients had been treated with chemotherapy, this may have played a role in the emergence of these broadly reactive autoantibodies.
TMEM70 mutations are a common cause of nuclear encoded ATP synthase assembly defect: further delineation of a new syndrome

Background The TMEM70 gene defect was recently identified as a novel cause of autosomal recessive ATP synthase deficiency. Most of the 28 patients with TMEM70 disorder reported to date display a distinctive phenotype characterised by neonatal onset of severe muscular hypotonia hypertrophic cardiomyopathy, facial dysmorphism, profound lactic acidosis, and 3-methylglutaconic aciduria. Almost all share a common Roma descent and are homozygous for a single founder splice site mutation. Methods Six new patients from four separate families, with clinical and biochemical diagnosis of ATP synthase deficiency, were studied. TMEM70 sequence analysis of the three exons and their flanking splice junction consensus sequences was performed in all patients. In addition their clinical phenotype and disease course was strictly studied. Results Four novel deleterious homozygous TMEM70 mutations were identified. The previously described clinical spectrum was expanded to include infantile onset cataract, early onset gastrointestinal dysfunction and congenital hypertonia with multiple contractures resembling arthrogryposis. The first characterisation of fetal presentation of the syndrome is also provided, featuring significant intrauterine growth retardation, severe oligohydramnios, fetal hypotonia, and myocardial wall thickening. Conclusions The current report corroborates the previously described unique phenotype of TMEM70 deficiency. The study identifies TMEM70 gene defect as a pan-ethnic disorder and further redefines it as the most common cause of nuclear-origin ATP synthase deficiency.
Marinobacter subterrani, a genetically tractable neutrophilic Fe(II)-oxidizing strain isolated from the Soudan Iron Mine

We report the isolation, characterization, and development of a robust genetic system for a halophilic, Fe(II)-oxidizing bacterium isolated from a vertical borehole originating 714 m below the surface located in the Soudan Iron Mine in northern Minnesota, USA. Sequence analysis of the 16S rRNA gene places the isolate in the genus Marinobacter of the Gammaproteobacteria. The genome of the isolate was sequenced using a combination of short- and long-read technologies resulting in two contigs representing a 4.4 Mbp genome. Using genomic information, we used a suicide vector for targeted deletion of specific flagellin genes, resulting in a motility-deficient mutant. The motility mutant was successfully complemented by expression of the deleted genes in trans. Random mutagenesis using a transposon was also achieved. Capable of heterotrophic growth, this isolate represents a microaerophilic Fe(II)-oxidizing species for which a system for both directed and random mutagenesis has been established. Analysis of 16S rDNA suggests Marinobacter represents a major taxon in the mine, and genetic interrogation of this genus may offer insight into the structure of deep subsurface communities as well as an additional tool for analyzing nutrient and element cycling in the subsurface ecosystem.
Ambiance Factors, Emotions, and Web User Behaviour:a Model Integrating and Affective and Symbolical Approach

The present paper addresses the efficiency of manipulating music in a merchant website, and it:- proposes a review of the literature on ambiance factors in advertising & shopping behaviour, capitalizing on it to:- propose a theoretical framework that enhances our understanding of the web-user behaviour in specific ambiance factors such as music, with a specific attention devoted to his loyalty, & affiliation behaviour;- a model of is proposed.
Making Controlled Experimentation More Informative in Inquiry Investigations

This dissertation incorporates three studies that examine how the design of inquiry based science instruction, dynamic visualizations, and guidance for experimentation contribute to physics students` understanding of science. I designed a week-long, technology-enhanced inquiry module on car collisions that logs students` interactions with a visualization. Students studied the module and responded to pretests, posttests, and embedded prompts that assessed students` understanding of motion graphs and collisions. In Study 1, students (N=148) made large, significant overall pretest to posttest gains. Regression models showed that the propensity for students to conduct controlled trials was the strongest predictor of learning when controlling for prior knowledge and other experimentation measures. Successful learners employed a goal-directed experimentation approach that connected their experimentation strategy to content knowledge. Study 2 investigated the effect of limiting students` experimentation on their planning, strategies, and learning outcomes. Students (N=58) made large, significant overall pretest to posttest gains. Students constrained to twelve trials isolated variables in their experiments better than the unconstrained students. However, the constrained students significantly underperformed the unconstrained students on the module assessments, indicating that isolating variables during experimentation did not lead to improved learning outcomes. In Study 3, students (N=166) were assigned to conditions that prompted them either to isolate or compare variables. Both groups made moderate, significant pretest to posttest gains. Students in the compare treatment used more diverse experimentation strategies than students in the isolate treatment. Compare students made nuanced interpretations of collision events based on threshold values. Case studies illustrate how comparing rather than isolating variables helped students use wide-ranging strategies to reach complex insights. The findings illustrate how students can benefit from experimentation strategies that do not isolate variables. Spontaneous exploration can help students test new questions that arise from unexpected results, informing the design of controlled tests that better reveal subtle characteristics of the variables. Guidance that encourages students to compare rather than isolate variables may have important benefits, such as prompting students to search for distinctions among the variables. The findings have important implications for the design of inquiry-based science instruction.
DNA SEQUENCES BASE CALLING BY PHRED: ERROR PATTERN ANALYSIS Prosdocimi¹,

PHRED is the most frequently used base caller algorithm in genome projects. An interesting point on PHRED utilization is the fact that a low score on some base may not actually correspond to a miscalling on that base, but it may stand for a putative error on the region around this base. In order to evaluate the efficiency of PHRED on base calling and base quality assigning, we have sequenced pUC18 and compared sequences called by PHRED with pUC18 published sequence using Smith-Waterman algorithm. Our results depict a detailed pattern of errors incorporated by the algorithm, confirm that PHRED provides appropriated base calling but: low-quality regions have their quality usually under-estimated, with most errors being mismatches. On the other side, high-quality regions have super-estimated quality, with errors mainly represented by deletions.
Energy-Harvesting-Aided Spectrum Sensing and Data Transmission in Heterogeneous Cognitive Radio Sensor Network

The incorporation of cognitive radio (CR) and energy harvesting (EH) capabilities in wireless sensor networks enables spectrum and energy-efficient heterogeneous CR sensor networks (HCRSNs). The new networking paradigm of HCRSNs consists of EH-enabled spectrum sensors and battery-powered data sensors. Spectrum sensors can cooperatively scan the licensed spectrum for available channels, whereas data sensors monitor an area of interest and transmit sensed data to the sink over those channels. In this paper, we propose a resource-allocation solution for the HCRSN to achieve the sustainability of spectrum sensors and conserve the energy of data sensors. The proposed solution is achieved by two algorithms that operate in tandem: a spectrum sensor scheduling (SSS) algorithm and a data sensor resource allocation (DSRA) algorithm. The SSS algorithm allocates channels to spectrum sensors such that the average detected available time for the channels is maximized, while the EH dynamics are considered and primary user (PU) transmissions are protected. The DSRA algorithm allocates the transmission time, power, and channels such that the energy consumption of the data sensors is minimized. Extensive simulation results demonstrate that the energy consumption of the data sensors can be significantly reduced, while maintaining the sustainability of the spectrum sensors.
KeLP at SemEval-2016 Task 3: Learning Semantic Relations between Questions and Answers

This paper describes the KeLP system participating in the SemEval-2016 Community Question Answering (cQA) task. The challenge tasks are modeled as binary classiﬁ-cation problems: kernel-based classiﬁers are trained on the SemEval datasets and their scores are used to sort the instances and produce the ﬁnal ranking. All classiﬁers and kernels have been implemented within the Kernel-based Learning Platform called KeLP. Our primary submission ranked ﬁrst in Sub-task A, third in Subtask B and second in Sub-task C. These ranks are based on MAP, which is the referring challenge system score. Our approach outperforms all the other systems with respect to all the other challenge metrics.
A Transgenic Mouse Model for Inducible and Reversible Dysmyelination

Oligodendrocytes are glial cells devoted to the production of myelin sheaths. Myelination of the CNS occurs essentially after birth. To delineate both the times of oligodendrocyte proliferation and myelination, as well as to study the consequence of dysmyelinationin vivo, a model of inducible dysmyelination was developed. To achieve oligodendrocyte ablation, transgenic animals were generated that express the herpes virus 1 thymidine kinase (HSV1-TK) gene under the control of the myelin basic protein (MBP) gene promoter. The expression of the MBP-TK transgene in oligodendrocytes is not toxic on its own; however, toxicity can be selectively induced by the systemic injection of animals with nucleoside analogs, such as FIAU [1-(2-deoxy-2-fluoro-β-δ-arabinofuranosyl)-5-iodouracil]. This system allows us to control the precise duration of the toxic insult and the degree of ablation of oligodendrocytes in vivo. We show that chronic treatment of MBP-TK mice with FIAU during the first 3 postnatal weeks triggers almost a total depletion of oligodendrocytes in the CNS. These effects are accompanied by a behavioral phenotype characterized by tremors, seizures, retarded growth, and premature animal death. We identify the period of highest oligodendrocytes division in the first 9 postnatal days. Delaying the beginning of FIAU treatments results in different degrees of dysmyelination. Dysmyelination in MBP-TK mice is always accompanied by astrocytosis. Thus, this transgenic line provides a model to study the events occurring during dysmyelination of various intensities. It also represents an invaluable tool to investigate remyelination in vivo.
SLR: Sustainable Longevity Routing Protocol for ad hoc networks

Ad hoc structure has a special characteristic because of which the nodes in the wireless ad hoc networks depend on batteries for power resources that restrain in giving power resources. Apart from QoS metrics like mobility and bandwidth, node survivability and power usage form the main feature in routing as hoc networks. Here we will dwell upon the issues of knowing the course with sources that sustainable and are essential in supporting excellence in wireless ad hoc networks. By routing path with highest obtainable power and less energy use can result in maintainable routing. A novel energy proficient weighted path routing protocol known as Sustainable Longevity Routing (SLR) Protocol is what we put forward. Our primary aim is to officially establish that the recommended weighted path routing protocol will meet the loop-freeness necessities and reliability. The maintainable asset assures that every nodule will make the right packet forwarding choice for the data packet to pass through the proposed path. Several wide mock-up experiments conducted by us proved that our projected weighted path routing protocol gives exemplary performance to know the high-throughput paths.
The rosebush picture sort : A diagnositic technique to differentiate sexually abused children from other children

This study (N = 123) contrasted a group of sexually abused children in treatment, aged 6 to 12 years, with two comparable groups—other non-sexually abused children in treatment, and non-abused, nontreatment children—to determine whether differences in Rosebush Picture selection could be demonstrated. All children underwent evaluation procedures that included completion of a 12 picture selection (the Rosebush Picture Sort) and the Culture-Free Self-Esteem Inventory-2 (CFSEI-2). A demographic questionnaire for each child was completed. Results showed no differences in picture selection or self-esteem scores of children at the beginning or end-treatment stage. Sexually abused children's Rosebush Picture Sort (RPS) selections at mid-treatment were different than both comparison groups. The self-esteem scores of the two clinical groups in mid-treatment were significantly lower than the scores of the non-abused, non-treatment group, but did not differ from one another. The findings indicate that sexually abused children identify Rosebush Picture Sort pictures differently than other children. It is possible that sexual abuse affects the internal working model of children differently than other types of abuse and trauma.
REFLEXIVITY AS ENACTMENT OF CRITICAL COMMUNITY PSYCHOLOGIES: DILEMMAS OF VOICE AND POSITIONALITY IN A MULTI-COUNTRY PHOTOVOICE STUDY

The performance of critical community psychologies is always contextual, intersubjective, embodied, and politicized in nature. In this article, we draw from the epistemological standpoint that researcher and participant subjectivities are fully implicated in the (co)-construction of knowledge and should therefore be documented and made retrievable. Through the lens of reflexivity, and drawing from an African-centered Photovoice project on youth representations of safety, we surface the tensions, contestations, instabilities, power variances, constraints and inventiveness in our research to expose voice and positionality dilemmas inherent in the enactment of critical community psychologies. We also seek to record context-sensitive practice to encapsulate how this particular innovative project operates in real-world settings. We argue that reflexivity is central to participatory forms of knowledge construction and consciousness raising directed at transformation, and rendered all the more significant in research contexts characterized by difference, inequality, and marginality.
SYSTEMS MODELING AND MODEL REDUCTION

Contents 1. Glossary Range space: A column vector x such that x = Ay for some column vector y is said to be in the range space of matrix A, i.e., x ∈ R (A). Null space: A column vector x such that Ax = 0 is said to be in the right null space of matrix A, i.e., y ∈ N R (A). A row vector x such that xA = 0 is said to be in the left null space of A, i.e., y ∈ N L (A). In this text the symbol (⊥) is used to denote a basis to N L (A). That is, x = 0 ∈ N L (A) if and only if ∃ y = 0 : x = yA ⊥ .
A novel low-power low-complexity chip solution for tunable UWB transmitter in CMOS 0.18µm technology

In this paper, a novel UWB transmitter chip is proposed, based on the 0.18 µm CMOS technology. A novel transmitting solution is adopted to realize a low-power and low-complexity physical implementation for future high data rate wireless component interconnect and implantable electronic applications. A UWB PA with standby, a digital ring on-off VCO, a subtractor for eliminating base-band component from the output of the VCO, and a narrow pulse generator are employed to achieve the chip with the maximum data-rate of 200Mbps, tunable-band of licensed 3∼7GHz, low-power of 8pJ/bit, and a small circuit area of 0.2mm2, of which the proposed subtractor, VCO, and PA play the important roles in reducing power dissipation. The simulation results verify that the proposed design is suitable for future potential applications.
Data privacy protection based on sensitive attributes dynamic update

Focused on the issue that the existing static data anonymous algorithm give dynamic data publication directly bring unexpected disclosure of private information frequently, based on the m-invariance model, an sensitive attribute of dynamic update f or privacy preserving algorithm (SDUPPA)is propose d. The algorithm breaks the table down quasi-identifier and sensitive attribute in data re-publication, which effectively protects data privacy. At the same time, it adopts orderly random switching technology to disturb sensitive attributes, so that the attacker ca n not accurately distinguish individual sensitive attribute information. Because SDUPPA algorithm meets the m-invariance privacy protection requirement and takes local generalization for quasi-identifier attributes, which reduces the information loss of over anonymous processing, so to some extent ensured the data quality. Research and analysis through data quality show that the SDUPPA algorithm can efficiently reduce the information loss and improve data security of the algorithm in dynamic data update environment.
Serial Glycosylated Hemoglobin Levels and Risk of Colorectal Neoplasia among Patients with Type 2 Diabetes Mellitus

Background: Hyperglycemia may increase the risk of colorectal neoplasia by serving as an energy source for neoplastic growth. We sought to determine whether glycemic control measured by serial hemoglobin A1c (HbA1c) was associated with the risk of colorectal adenoma. Methods: Among a cohort of patients with type 2 diabetes mellitus who received health care within the Kaiser Permanente Northern California from 1994 to 2005, we conducted 2 case–control analyses. Cases had at least 1 colorectal adenoma identified at either colonoscopy (analysis 1) or sigmoidoscopy (analysis 2). Controls had no colorectal neoplasia identified at the corresponding endoscopic examination. Serial HbA1c levels between the cases and the controls were compared using a longitudinal model. Results: Case–control analysis 1 included 4,248 patients, of whom 1,296 (31%) had at least 1 adenoma. The adjusted mean HbA1c levels among those without any adenomas was 8.20% versus 8.26% among those with at least 1 adenoma, a difference of 0.06% (95% CI = −0.02 to 0.14, P = 0.16). Case–control analysis 2 included 9,813 patients, of whom 951 (10%) had at least 1 distal adenoma. The adjusted mean HbA1c levels among those without any distal adenomas was 8.32% versus 8.37% among those with at least 1 distal adenoma, a difference of 0.05% (95% CI = −00.04 to 0.14, P = 0.25). The results were similar for advanced adenomas. Conclusions: Glycemic control was not associated with the risk of colorectal adenoma among diabetic persons. Impact: These results would suggest that glycemic control is unlikely to confound the reported association between diabetes medications and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev; 19(12); 3027–36. ©2010 AACR.