Miracle-dz/UniFAR-FTUs huggingface dataset:
Stator and rotor vent modelling in a MVA rated synchronous machine

An investigation into the solution dependence of a conjugate heat transfer computational fluid dynamics (CFD) model of a synchronous generator, with respect to meshing, has been carried out. Utilising CFD as a tool for investigating the airflow and thermal performance of electrical machines is increasing. Meshing is a vital part of the CFD process, but its importance is often misunderstood or overlooked in the context of electrical machine analyses; partly due to the relative mesh independency of the finite element analysis (FEA) numerical method. This paper demonstrates how a relatively complex, air-cooled generator CFD model can be considerably influenced by changes in the mesh. Flow rate, velocity and windage effects are assessed as a function of the mesh adopted. Mesh changes have been shown to affect the mass flow rate through a single vent by up to 55% and the associated heat transfer coefficient by 128%.
Shortlasting, Unilateral Neuralgiform Headache Attacks with Conjunctival Injection, Tearing, Sweating, and Rhinorrhea

Three grown-up males with a long-lasting history of rather uniform, unilateral headache in the ocular-periocular area, in cluster fashion, are examined. Pain paroxysms of short duration (15–60 sec) appear up to 5–30 times per h. The headache is unilateral without side shift. Conjunctival injection appears at the very beginning of the attack and is partly massive, lasting the entire duration of the attack, and fading away at the end of it. Tearing (massive), forehead sweating (subclinical) and rhinorrhea, all on the symptomatic side, accompany the attack. In the youngest patient, the headache became chronic after clustering for six months initially, and after approximately 31/2 years it became bilateral. However, even in this patient, a clear unilateral pain preponderance prevails, and the autonomic disturbances are all on the original pain side. Attacks can partly be precipitated by chewing, eating (e.g. citrus fruits), moving the head, etc. The headache is completely refractory to drug therapy, including indomethacin.
A Role for the Proton-coupled Folate Transporter (PCFT-SLC46A1) in Folate Receptor-mediated Endocytosis*

Recently, this laboratory identified a proton-coupled folate transporter (PCFT), with optimal activity at low pH. PCFT is critical to intestinal folate absorption and transport into the central nervous system because there are loss-of-function mutations in this gene in the autosomal recessive disorder, hereditary folate malabsorption. The current study addresses the role PCFT might play in another transport pathway, folate receptor (FR)-mediated endocytosis. FRα cDNA was transfected into novel PCFT+ and PCFT– HeLa sublines. FRα was shown to bind and trap folates in vesicles but with minimal export into the cytosol in PCFT– cells. Cotransfection of FRα and PCFT resulted in enhanced folate transport into cytosol as compared with transfection of FRα alone. Probenecid did not inhibit folate binding to FR, but inhibited PCFT-mediated transport at endosomal pH, and blocked FRα-mediated transport into the cytosol. FRα and PCFT co-localized to the endosomal compartment. These observations (i) indicate that PCFT plays a role in FRα-mediated endocytosis by serving as a route of export of folates from acidified endosomes and (ii) provide a functional role for PCFT in tissues in which it is expressed, such as the choroid plexus, where the extracellular milieu is at neutral pH.
Real-time functional magnetic resonance imaging.

Magnetic resonance imaging (MRI) has been shown to be useful in the detection of brain activity via the relatively indirect coupling of neural activity to cerebral blood flow and subsequently to magnetic resonance signal intensity. Recent technical advances have made possible the continuous collection of successive images at a rate rapid compared with such signal changes and in the statistical processing of these image time series to produce tomographic maps of brain activity in real time, with updates of 10 frames/s or better. We describe here our preferred method of real-time functional MRI and some of the early results we have obtained with its use.
Faith and fakes – dealing with critical information in decision analysis

ABSTRACT Decision making subject to uncertain information, whether fake or factual, in the context of management of socio-technical systems, is critically discussed from both philosophical and operational perspectives. In dealing with possible fake, incorrect and/or factual information we take the perspective that any information utilised as basis for supporting decisions, has to be dealt with in exactly the same manner – in accordance with Bayesian decision analysis. The important issue is to identify and model the scenarios through which information may cause adverse consequences and to account for their potential effects. To this end we first provide a mapping of how information affects the decision making context and a categorisation of causes for information leading to adverse consequences. Secondly, we introduce a decision analytical framework aiming to optimise decision alternatives for managing systems including not only one possible system model but a set of different possible system models. As a means for assessing the benefit of collecting additional information, we utilise Value of Information analysis from Bayesian decision analysis. Finally, a principal example is provided which illustrates selected aspects of how possibly fake information affects decision making and how it might be dealt with.
Analysis of promoter sequences from Lactobacillus helveticus CNRZ32 and their activity in other lactic acid bacteria

Aims: To clone and analyse seven putative promoter fragments (pepC, pepN, pepX, pepO, pepE, pepO2, hsp17) from Lactobacillus helveticus CNRZ32 for their expression in Lact. helveticus CNRZ32, Lact. casei ATCC334 and Lactococcus lactis MG1363.
Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia (‘pseudodementia’)

Synopsis Twenty-six elderly (> 60 yrs) patients with DSM-III major depression were compared to 13 patients with NINCDS/ADRDA probable Alzheimer's disease (AD), and to 31 screened normal controls. Subjects were matched on age and sex. Fifteen of the 26 depressed patients were cognitively impaired on the Mini-Mental State Examination (MMSE) upon admission, but after treatment returned to the normal range. These 15 patients were defined as having the dementia syndrome of depression (DOD). The remaining 11 depressed patients were termed depressed, cognitively normal (DCN). All subjects received standardized cranial CT scans for assessment of ventricular brain ratio (VBR) and CT attenuation numbers. Subjects also received neuropsychological evaluation. CT values for the 26 depressed patients lay between those of AD patients and normal controls. CT values for the DOD subgroup clustered near those of AD patients. Patterns of cognitive deficits and correlations of CT attenuation values with cognitive measures were also similar in AD and DOD. Most patients were reassessed at a mean of two years after initial testing; of the 11 of the 15 DOD re-examined, only one had undergone cognitive decline. By contrast, all AD patients retested had declined significantly. Episodes of DOD and DCN tended to ‘breed true’. This study suggests that while patients with DOD may have underlying structural brain abnormalities, obvious short-term progression to AD does not commonly occur.
Effect of ionizing radiation on the male reproductive system.

INTRODUCTION AND OBJECTIVE In the light of current data concerning the growing exposure to ionizing radiation (IR) originating from atrificial sources, especially from medical ones, and also related to occupational exposure, it is justifiable to systematize the state of knowledge concerning the effect of IR on the male reproductive system. BRIEF DESCRIPTION OF THE STATE OF KNOWLEDGE There is no basis for the application of the hypothesis of hormesis in the area of male reproductive health. Regarding the impact of IR on spermatogenesis, spermatogonia are less susceptible to the occurrence of DNA damage after exposition to IR, but are characterized by slower DNA repair compared to somatic cells. Damage to the genes after exposure to IR is possible at each stage of spermatogenesis; however, haploidal spermatids show the highest radiosensitivity in this respect. The genetic risk of the cells differentiating during spermatogenesis is limited to one cycle of spermatogenesis, whereas the genetic instability may persist for the whole period of life, and DNA damage induced by IR may be transmitted to future generations. The minimum dose causing detectable DNA damage was 30 Gy. While exceeding this dose, the number of single-strand DNA breaks increases. Among males exposed to IR, a decrease was observed in sperm motility and in the percentage of morphologically normal spermatozoa as well as in an intensification of vacuolization. The genetic material in the sperm of these males showed higher fragmentation and methylation of genomic DNA. CONCLUSION In the context of the epidemiological situation concerning the prevalence of infertility, while assessing the health effects of exposure to IR from artificial, including medical sources, the reproductive risk should be considered.
Charge Trapping Memory Characteristics of Amorphous-Indium–Gallium–Zinc Oxide Thin-Film Transistors With Defect-Engineered Alumina Dielectric

A nonvolatile memory (NVM) based on an amorphous-indium-gallium-zinc oxide (a-IGZO) thin-film transistor (TFT) with defect-engineered gate insulator was demonstrated. The gate insulator was a blocking alumina/storage alumina/tunneling alumina stack structure, which was simply assembled in a single atomic layer deposition step. The memory device showed a positive shift of threshold voltage as large as 14.4 V after +20 V, 1 s programming. In contrast, the memory erasing was not sensitive to negative gate voltage in the dark. Once programmed, the memory can only be light erased. Furthermore, the light combined with a negative bias improved the erasing speed effectively. In addition, a 10-year memory window as large as 7.5 V was extrapolated at room temperature with a charge loss of 34.7%. Based on the observation of blisters in the storage alumina layer after high temperature annealing, Fourier transform infrared spectroscopy measurement and first-principles calculations, the high electron storage capacity can be attributed to the deep defect levels in the storage alumina layer, which were originated from hydrogen impurity. This a-IGZO TFT charge trapping NVM with high performance and simple process is a candidate device for the application of fully functional transparent system on panel.
Stereological Evaluation of the Seminiferous Tubules of Rats after Maternal Undernutrition during the Lactation Period

The goal of this study is to evaluate, through stereological methods, some structural aspects of offspring testes whose dams were submitted to protein and energy-restricted diets during the lactation period. At birth, dams were separated into 3 groups: control group (C), receiving a diet with 23% protein; protein-restricted group (PR), receiving a diet with 8% protein; energy-restricted group (ER), receiving a diet with 23% protein in restricted quantities. At weaning, the offspring was anesthetized and perfused with formalin solution. Then, the testes were excised and processed using routine histological methods. Compared to the C group, both PR and ER groups had a significant reduction in the testis weight (PR = 65%, ER = 60%, p < 0.01), in the total area (PR = 23%, ER = 32%, p < 0.01), in the luminal area (PR = 30%, ER = 36%, p < 0.01), in the epithelial area (PR = 21%, ER = 27%, p < 0.01), and in the epithelial height (PR = 17%, ER = 23%, p < 0.01) of the seminiferous tubule. We conclude that maternal malnutrition during lactation leads to structural changes in the testis that could be responsible for future alterations in this organ physiology.
Within-host transmission strategies of transovarial, feminizing parasites of Gammarus duebeni

The amphipod Gammarus duebeni harbours several species of vertically transmitted, feminizing microsporidian parasites. G. duebeni were collected from 3 localities in the UK. Animals from Budle Bay, Northumberland, were infected with Octosporea effeminans, and those from Millport, Isle of Cumbrae and Fenham Flats, Northumberland were infected with microsporidia of the genus Nosema. We derived expected distributions of parasites per host embryonic cell by modelling parasite transmission as a multitype, Galton–Watson branching process. Parasite prevalence (proportion of females infected) was significantly heterogeneous among localities. Parasite burden in zygotes was much higher for females infected with Nosema than in animals infected with O. effeminans. There was no significant difference between localities in the number of Nosema in the zygotes. Comparison of models and data from 64-cell host embryos showed that the distributions of parasites per cell were consistent with the hypothesis that sorting of parasites into daughter cells is biased for at least 1 cell lineage. Host embryos infected with O. effeminans could expect to contain a growing number of parasites in each cell generation within such biased cell lineages; similar estimates for Nosema predict a decline in the number of parasites per cell within a biased lineage. We discuss the possibility that the 2 species of parasite may be employing different strategies in order to ensure transmission to the next host generation.
Annotation d’expressions polylexicales verbales en français (Annotation of verbal multiword expressions in French)

Nous décrivons la partie française des données produites dans le cadre de la campagne multilingue PARSEME sur l’identification d’expressions polylexicales verbales (Savary et al., 2017). Les expressions couvertes pour le français sont les expressions verbales idiomatiques, les verbes intrinsèquement pronominaux et une généralisation des constructions à verbe support. Ces phénomènes ont été annotés sur le corpus French-UD (Nivre et al., 2016) et le corpus Sequoia (Candito & Seddah, 2012), soit un corpus de 22 645 phrases, pour un total de 4 962 expressions annotées. On obtient un ratio d’une expression annotée tous les 100 tokens environ, avec un fort taux d’expressions discontinues (40%).
A Pilot Study on Safety Climate in Chinese Hospital

Objectives The present paper has 2 primary objectives as a pilot study on health-care safety climate in China: to develop its prototypical model well fit to the country’s current hospital situations and validated external reliability and to elicit essential characteristics of safety climate for hypothetical general features in Chinese health care. Methods A safety climate survey was carried out in 2008 at a university hospital in Shanghai, using an Operating Room Management Attitudes Questionnaire. We collected 1056 valid responses from doctors and nurses with 81% of overall response rate. Results A 9-dimension model of safety climate was developed by applying principal component analysis to the entire sample with 44% of cumulative variance accounted for. Compared with the Japanese sample, safety climate in the Chinese hospital was characterized as strong awareness of own competence, positive attitudes to organization, but large power distance and unrealistic staff recognition of human error. Criterion validity of the construct was in part assured by significant correlations of 4 dimensions with self-reported staff behavior of accident reporting. Conclusions Safety climate has been not yet mature in the hospital surveyed that might be partly tied with blame culture. Considering health-care policies, procedures, and management styles shared with many other health-care organizations as well as Chinese culture, we would hypothesize that the immature nature is common in Chinese health care as overall characteristics of safety climate. From these results, we would suggest that a nonpunitive health-care culture should be fostered to improve patient safety in China.
Cooperativity in Transcription Factor Binding to the Coactivator CREB-binding Protein (CBP)

The interactions between cAMP-response element-binding protein (CREB)-binding protein (CBP) and gene-specific transcription factors play an important role in activation of transcription from numerous genes. Cooperative interactions between CBP and multiple transcriptional activators may provide a mechanism for synergistic increases in transcriptional activation. Here we report the characterization of ternary complexes formed by the KIX domain of CBP and the transactivation domain of the trithorax group protein mixed lineage leukemia protein (MLL), together with either the phosphorylated kinase-inducible domain (pKID) of CREB or the activation domain from c-Myb. Isothermal titration calorimetry experiments show that KIX in complex with the MLL activation domain binds the c-Myb activation domain and pKID domain with 2-fold higher affinity than does the KIX domain alone. Thus, the activation domains of Myb and MLL or of pKID and MLL bind cooperatively to KIX. The thermodynamics of these interactions imply different mechanisms of binding cooperativity for the two ternary complexes; the KIX·MLL·pKID complex is stabilized by entropy increases, whereas the enhancement of Myb binding in the presence of the MLL activation domain is due to more favorable enthalpy. NMR experiments show that the MLL-binding site on KIX is distinct from the surface that binds the pKID and c-Myb activation domains. Our data indicate that KIX can directly mediate cooperative interactions between pairs of transcriptional regulatory proteins. In the case of MLL and c-Myb, both proteins are involved in proliferation of hematopoietic cells and leukemogenesis, and synergistic interactions mediated by CBP may play a functional role.
A Web-based Project Allocation System Interim Report

This project presents a stable matching problem between students and projects called the Student-Project Allocation problem (spa) where students can work collaboratively as a group. A matching between two sets students S and projects P is stable if there are no two pairs (s, p) and (s′, p′) such that s prefers p′ to p and s′ prefers p to p′. Extensive researches have been carried out in relation to the stable matching problem and yet only few have addressed the spa problem depicted in this project. The spa with group projects is studied in this project. An algorithm called the SpaGroup is designed which aims to generate the stable matching. In addition, a web application called the Project Allocation System (PAS) is developed to simulate the problem in an actual scenario. This enables users to securely submit their preferences online. It can also be used as a report generating tool in regard to matching details. Currently, a prototype has been developed. This prototype implemented the algorithm to solve the spa without group projects. The goal is to convert it to solve the spa with group projects. Besides, a preliminary draft on the Spa-Group algorithm has been done which is based on an existing algorithm. Next, a preliminary work on the PAS will be followed. This will address the database and user-interface design of the PAS. The next deliverable will be the PAS demo system. This demo system contains basic functions of the system and will serve as the evolutionary prototype of the final PAS.
The Effect of Kinesio Taping on Calf Pain and Extensibility Immediately After Its Application and After a Duathlon Competition

A sample of 34 duathlete volunteers was recruited from the competitors in a duathlon sprint. Calf pain and extensibility measures were obtained at baseline, immediately after taping, and 10–15 minutes after competition. Kinesio tape (KT) was applied on the calf of duathletes 20–90 minutes before the competition, only on one of their legs, with the other leg acting as a control. Repeated measures ANOVA results on calf extensibility did not show statistically significant differences [F(2) = 0.180; p = 0.836]. Nevertheless, Friedman test results on calf pain showed statistically significant differences [χ2(2) = 10.111; p = 0.006]. Additionally, post hoc pairwise comparison showed statistically significant differences from baseline to after competition (p = 0.006). Applying KT on calves seems to reduce muscle pain produced by the competition among duathletes with no apparent musculoskeletal disorder. Kinesio tape (KT) application, however, does not affect the calf extensibility immediately and after a duathlon competition.
Unleashing the Full Potential of Blockchain Technology for Security-Sensitive Business Applications

Companies are eager to invest in the emerging blockchain technology, but often fail to integrate this technology into real-world business applications that go beyond cryptocurrencies or pure demonstrators. The reason often lies in specific requirements related to data security and privacy. Current blockchain solutions are not able to meet these requirements, preventing a broad adoption of blockchain technology in business applications. To tackle this problem, we introduce UBI: a Universal Blockchain Integrator. UBI acts as a middleware between a company’s legacy IT infrastructure and off-the-shelf blockchain solutions. UBI enriches the functionality of these solutions so that they meet specific security and privacy requirements. Its successful implementation shows the feasibility of the proposed solution. First evaluation results demonstrate its potential for real-world business applications.
Construction of an inactivated typhoid vaccine candidate expressing Escherichia coli heat‐labile enterotoxin B subunit and evaluation of its immunogenicity in a murine model

Purpose. Typhoid fever caused by Salmonella enterica serovar Typhi has contributed to the global public health burden, particularly in developing countries. In this study, an S. Typhi ghost was developed and its capacity as a vaccine candidate against typhoid fever was assessed. Methodology. An asd+ plasmid pJHL187 harbouring a ghost cassette comprising the PhiX 174 Elysis gene tightly controlled under the convergent promotor system was transformed into an asd gene‐deleted mutant S.Typhi strain (STG). The eltB gene encoding the E. coli heat‐labile enterotoxin (LTB) protein was subcloned into a foreign antigen delivery cassette of pJHL187 to increase mucosal immunity. Results. The stringent repression and expression of the lethal E lysis gene in the system allowed stable production of the ghost strain and secretion of LTB, which was confirmed by immune blot analysis. The level of IgG and sIgA was significantly increased in the mice subcutaneously immunized with STG‐LTB compared to the non‐immunized mice (P<0.05). The CD3+CD4+ T cell subpopulation was augmented in the immunized group (P<0.05) and showed the increment of immunomodulatory cytokines IL‐2, IL‐6, IL‐12, IL‐17 and IFN‐&ggr; in in vitro restimulated splenocytes isolated from the inoculated mice. The serum bactericidal activity of antibodies generated in the rabbits injected with STG‐LTB was proved by the elimination of approximately 87.5% of wild‐type S. Typhi in the presence of exogenous complement. Conclusion. The results demonstrated that the STG‐LTB ghost effectively enhanced the immunological responses, meaning that STG‐LTB is potentially available as a vaccine candidate against typhoid fever.