Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of BM-573, a Novel Thromboxane A2 Inhibitor, on Pulmonary Hemodynamics in Endotoxic Shock

Thromboxane A 2 is considered to be partially responsible for the increase in pulmonary vascular resistance observed after endotoxin administration and to participate in proinflammatory reactions. The effects of a novel dual TXA 2 synthase inhibitor and TXA 2 receptor antagonist (BM-573) on pulmonary hemodynamics were investigated in endotoxic shock. 30 mins before the start of a 0.5 mg/kg endotoxin infusion, 6 pigs (Endo group) received a placebo infusion and 6 other pigs (Anta group) received a BM-573 infusion. In Endo group, pulmonary artery pressure increased from 25 ± 1.8 (T0) to 42 ± 2.3 mmHg (T60) (p < 0.05) after endotoxin infusion while, in Anta group, it increased from 23 ± 1.6 (T0) to 25 ± 1.5 mmHg (T60). This difference is due to a reduction in pulmonary vascular resistance in Anta group while pulmonary arterial compliance changes in Endo group remained comparable with the evolution in Anta group. In Endo group, PaO 2 decreased from 131 ± 21 (T0) to 74 ± 12 mmHg (T300) (p < 0.05), while in Anta group, PaO 2 was 241 ± 31 mmHg at the end of the experimental period (T300). These results demonstrate that TXA 2 plays a major role in pulmonary vascular changes during endotoxin insult. Concomitant inhibition of TXA 2 synthesis and of TXA 2 receptors by BM-573 inhibited the pulmonary vasopressive response during the early phase of endotoxin shock as well as the deterioration in arterial oxygenation.
Diagnostic yield of specific inhalation challenge in hypersensitivity pneumonitis

Reliable methods are needed to diagnose hypersensitivity pneumonitis. The aim of the study was to establish the diagnostic yield of specific inhalation challenge (SIC) in patients with hypersensitivity pneumonitis. All patients with suspected hypersensitivity pneumonitis in whom SIC was performed (n=113) were included. SIC was considered positive when patients showed a decrease of >15% in forced vital capacity (FVC) or >20% in diffusing capacity of the lung for carbon dioxide, or a decrease of 10% to 15% in FVC accompanied by a temperature increase of 0.5°C within 24 h of inhalation of the antigen. SIC was positive to the agents tested in 68 patients: 64 received a diagnosis of hypersensitivity pneumonitis and SIC results were considered false-positive in the remaining four patients. In the SIC-negative group (n=45), 24 patients received a diagnosis of hypersensitivity pneumonitis and SIC results were considered false-negative, and 21 patients were diagnosed with other respiratory diseases. The sensitivity and specificity of the test were 72.7% and 84%, respectively. Having hypersensitivity pneumonitis caused by an antigen other than birds or fungi predicted a false-negative result (p=0.001). In hypersensitivity pneumonitis, positive SIC testing virtually confirms the diagnosis, whereas negative testing does not rule it out, especially when the antigenic sources are not birds or fungi. Specific inhalation challenge can be very useful for establishing the diagnosis of hypersensitivity pneumonitis http://ow.ly/zxszi
The Multifocal ERG in Early Detection of Diabetic Retinopathy

To assess retinal changes in diabetic eyes at early stage of retinopathy, retinal responses were examined using multifocal ERG. Seven healthy subjects, 16 diabetics with no apparent retinopathy (NDR) and 9 diabetics who had background diabetic retinopathy (BDR) underwent multifocal ERG testing. The first slice of the second order kernel (K21) were extracted from multifocal ERG record and summed. Three major peaks (P1, N1 and P2) on the trace of summed K21 are evaluated across all subjects. With their amplitude and implicit time as 6 features, linear classifiers were built. These classifiers were used to discriminate eyes of control, NDR and BDR subjects. The classification error dropped significantly
Demonstration of carbon-carbon bond cleavage of acetyl coenzyme A by using isotopic exchange catalyzed by the CO dehydrogenase complex from acetate-grown Methanosarcina thermophila

The purified nickel-containing CO dehydrogenase complex isolated from methanogenic Methanosarcina thermophila grown on acetate is able to catalyze the exchange of [1-14C] acetyl-coenzyme A (CoA) (carbonyl group) with 12CO as well as the exchange of [3'-32P]CoA with acetyl-CoA. Kinetic parameters for the carbonyl exchange have been determined: Km (acetyl-CoA) = 200 microM, Vmax = 15 min-1. CoA is a potent inhibitor of this exchange (Ki = 25 microM) and is formed under the assay conditions because of a slow but detectable acetyl-CoA hydrolase activity of the enzyme. Kinetic parameters for both exchanges are compared with those previously determined for the acetyl-CoA synthase/CO dehydrogenase from the acetogenic Clostridium thermoaceticum. Collectively, these results provide evidence for the postulated role of CO dehydrogenase as the key enzyme for acetyl-CoA degradation in acetotrophic bacteria.
Identifying the best practices in green operations strategy of leading mobile phone producers

The aim of this research is identifying the best practices in green operations strategy of leading mobile phone producers over the period 2008-2011. Six leading cases were investigated (Apple, Nokia, Ericsson, Sony Ericsson, Samsung, and RIM). The sustainability annual reports of these cases were analysed over a period 2008-2011. Two phased analysis approach was adopted within clusters and between clusters analysis. This study revealed that; the significant strategic groups were; solid waste management, hazard material management and hazard material and solid waste management. Indicative models for the relationship between actions and key green performance indicators were developed. The best practices of green operations strategies have not been investigated by previous studies. The sustainability advocates and researchers have some facts about the maturity of green practices and the issues require more concern in the future. The managers of other companies who concern about the sustainability can adopt the most effective reported actions in this study.
New Public Management in the UK: Enduring Legacy or Fatal Remedy?

In assessing developments in the UK subsequent to the New Public Management (NPM) reforms of the 1980s and 1990s an important question is whether the structures and practices created by the NPM reforms are enduring or whether, as so often is the case in administrative reform, they are quickly being replaced. There is some evidence that certain parts of the NPM reform have been ‘fatal remedies’ -the reforms originally intended to solve problems of public sector performance have led to side and perverse effects, creating the conditions for their own demise. These processes have been reinforced by changes because of policy makers’ altered priorities. The ‘fatal remedies’ have been especially found in some aspects of competitive NPM structures and in disaggregated corporate units involving splitting ‘policy’ from ‘service delivery. ’ However, many parts of NPM, especially disaggregated units more generally and the use of private providers appear to be a more enduring legacy. In some of these areas, rather than removing NPM structures, new mechanisms have been developed to ameliorate some of their undesirable side-effects, particularly through the increased use of regulation of government.
Prospective psychosocial monitoring of living kidney donors using the SF-36 health survey

Background. Psychosocial assessment and monitoring of living kidney donors is not yet standard practice, despite calls for it in the literature. Methods. Psychosocial assessment of living kidney donors was performed preoperatively and 4 months postoperatively, using the SF-36 Health Survey, the Patient Health Questionnaire psychiatric assessment, and semistructured interview. Results. Assessment was acceptable to the majority of donors; 92% (44) of 48 consecutive donors completed both assessments. Preoperatively, both physical function (SF-36 Physical Component Score [PCS]) and psychosocial function (SF-36 Mental Component Score [MCS]) were significantly higher than community (state of Victoria) norms. Postoperatively, PCS and MCS fell significantly, but not below the Victorian norm. Seven donors (16%) developed adjustment disorder or anxiety disorder; their MCS were significantly lower than those without psychiatric disorder. Conclusions. It is concluded that routine psychosocial assessment performed by a psychiatrist, including the use of questionnaires, is acceptable to donors and identifies those impaired. Potential donors need to be well prepared for such assessment and well educated about the extent of physical and psychosocial impairment that might occur in the postoperative period.
Ultra-Low-Latency Parallel SC Polar Decoding Architecture for 5G Wireless Communications

In this paper, we newly present a novel parallel polar decoding architecture that significantly reduces the processing latency for 5G wireless communications. Based on the original decoding tree, the proposed scheme first constructs the small trees that generate multiple soft-decision messages in parallel, potentially reducing the decoding latency compared to the previous serialized schemes. The hard-decision estimates are then calculated at the following merging step to decide the decoded outputs and to update the parallel trees. For each parallel tree, the parallel pruning scheme is newly utilized to further optimize the processing latency. In addition, we introduce an efficient parallel decoder architecture, successfully supporting the proposed low-latency algorithm. Implementation results show that the proposed 8-parallel polar decoder in 65nm CMOS uses only 267ns to decode a (1024, 512) polar codeword of 5G system, which is 1.67 times faster than the state-of-the-art design.
Prevalence of binge and loss of control eating among children and adolescents with overweight and obesity: An exploratory meta‐analysis

OBJECTIVE Due to the inconsistency of the research findings in the current literature, the prevalence of binge and loss of control (LOC) eating among children and adolescents with overweight and obesity remains unclear. By using the meta-analytic approach, this article aimed at exploring the prevalence of binge/LOC eating among children and adolescents with overweight and obesity, and at identifying potential moderators, which may have contributed to the heterogeneity of the existing research findings. METHOD Four electronic databases (PubMed, Web of Science, EBSCOhost, and ProQuest Dissertations & Theses Global) were searched. The search period covered the research literature up to April 2016. A random-effects meta-analysis model was used to estimate the overall prevalence. Weighted random-effects model ANOVAs and univariate random-effects meta-regression were applied for the analysis of categorical moderators and continuous moderators, respectively. RESULTS Thirty-six studies were identified. The overall prevalence of binge/LOC eating was estimated to be 26.3% (95% CI: 23.1-29.7%), with 22.2% (95% CI: 18.6-26.3%) and 31.2% (95% CI: 26.1-36.9%) for binge eating and LOC eating, respectively. Treatment status, binge eating vs. LOC eating and assessment methods appeared to be associated with the inconsistencies of the prevalence rates across the studies. DISCUSSION The findings of this meta-analysis indicated that binge/LOC eating was prevalent among more than one quarter of children and adolescents with overweight and obesity. Considering the close relationship between disordered eating behaviors and obesity, future research concerning overweight and obesity among children and adolescents needs to take binge/LOC eating into consideration. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2017; 50:91-103).
The Determinants of Earnings Management in Developing Countries: A Study in the Tunisian Context

This paper investigates the factors that determine earnings management in emerging countries through the example of Tunisia. The empirical analysis is conducted by dividing the factors into two principal group — incentive group and constraint group — and by using data of 19 Tunisian listed companies collected from the Tunisian stock exchange for the period 2003-2009. To estimate discretionary accruals, three models, namely, Dechow et al. (1995) (modified Jones model), Kothari et al. (2005) and Raman and Shahrur (2008), have been used. In order to test for determinants of earning management, the residuals of these models (discretionary accruals) are regressed on a set of explanatory variables that are hypothesized to have an impact on earnings management. Empirical analysis reveals that on the whole, the results seem to depend on the model used to estimate the discretionary accruals. In particular, six (indebtedness, firm size, performance, cumulation of the managerial and the board chair roles, managerial propriety, and dividend policy) of the nine variables considered are found to significantly determine earnings management. In addition, empirical results show that three (firm size, cumulation of the managerial and the board chair roles, and managerial propriety) out of the six determinants do not have a sign as expected.
Role of CspC and CspE in Regulation of Expression of RpoS and UspA, the Stress Response Proteins in Escherichia coli

ABSTRACT Nine homologous proteins, CspA to CspI, constitute the CspA family of Escherichia coli. Recent studies are aimed at elucidating the individual cellular functions of these proteins. Two members of this family, CspC and CspE, are constitutively produced at 37°C. In the present study, these two proteins were evaluated for their cellular role(s). The expression of three stress proteins, OsmY, Dps, and UspA, is significantly affected by the overexpression and deletion of CspC and CspE. RpoS is a regulatory element forosmY and dps. Further analysis showed a larger amount and greater stability of the rpoS mRNA as well as a higher level of RpoS itself with the overexpression of CspC and CspE. This suggests that CspC and CspE upregulate the expression of OsmY and Dps by regulating the expression of RpoS itself. Indeed, this upregulation is lost in the ΔrpoS strain. Other RpoS-controlled proteins such as ProP and KatG, are also upregulated by the overexpression of CspC. The present study suggests that CspC and CspE are the important elements involved in the regulation of the expression of RpoS, a global stress response regulator, and UspA, a protein responding to numerous stresses. In the light of these observations, it seems plausible that CspC and CspE function as regulatory elements for the expression of stress proteins in the complex stress response network of E. coli.
Applications of 3D City Models: State of the Art Review

In the last decades, 3D city models appear to have been predominantly used for visualisation; however, today they are being increasingly employed in a number of domains and for a large range of tasks beyond visualisation. In this paper, we seek to understand and document the state of the art regarding the utilisation of 3D city models across multiple domains based on a comprehensive literature study including hundreds of research papers, technical reports and online resources. A challenge in a study such as ours is that the ways in which 3D city models are used cannot be readily listed due to fuzziness, terminological ambiguity, unclear added-value of 3D geoinformation in some instances, and absence of technical information. To address this challenge, we delineate a hierarchical terminology (spatial operations, use cases, applications), and develop a theoretical reasoning to segment and categorise the diverse uses of 3D city models. Following this framework, we provide a list of identified use cases of 3D city models (with a description of each), and their applications. Our study demonstrates that 3D city models are employed in at least 29 use cases that are a part of more than 100 applications. The classified inventory could be useful for scientists as well as stakeholders in the geospatial industry, such as companies and national mapping agencies, as it may serve as a reference document to better position their operations, design product portfolios, and to better understand the market.
Frequent HOXA 11 and THBS 2 Promoter Methylation , and a Methylator Phenotype in Endometrial Adenocarcinoma 1

Purpose: This study was designed to determine whether there is a methylator phenotype in stage I and II endometrioid endometrial adenocarcinoma, and if so, whether methylation correlates with recurrence. Experimental Design: Bisulfite-converted DNAs from 24 stage I and II primary cancers (12 recurrent and 12 nonrecurrent), and 5 endometrial cancer cell lines were analyzed for methylation in the promoter regions of seven genes. A methylation index (MeI) was calculated for each tumor. Frequent HOXA11 and THBS2 methylation prompted analysis of case-matched bloods and 25 additional nonrecurrent primary cancers. Statistical analysis included Fisher’s exact and Student t tests. Results: Rates of methylation in the initial tumor series were as follows: HOXA11, 70.8%; THBS2, 62.5%; MLH1, 33.3%; CTNNB1, 16.7%; VDR, 4.2%; CDKN2A, 4.2%; and THBS1, 0%. There was no difference in the MeI of recurrent and nonrecurrent cases. However, cell lines had higher mean MeI. High rates of HOXA11 and THBS2 methylation were confirmed in the additional nonrecurrent tumors. None of the 24 case-matched bloods had HOXA11 methylation, whereas three blood DNAs showed THBS2 methylation. There was a statistically significant difference in the rate of HOXA11 methylation in recurrent and nonrecurrent tumors (P 0.0167). Conclusions: Endometrial adenocarcinomas have a methylator phenotype. No correlation between MeI and clinicopathologic variables in early stage tumors was observed. High rates of methylation were found in the HOXA11 and THBS2 promoter regions. HOXA11 promoter methylation was significantly more frequent in recurrent than nonrecurrent cases. HOXA11 methylation in early stage endometrial cancer is associated with poor outcome.
Chemical Synthesis of (S)-4,5-Dihydroxy-2,3-pentanedione, a Bacterial Signal Molecule Precursor, and Validation of Its Activity in Salmonella typhimurium*

We describe an original, short, and convenient chemical synthesis of enantiopure (S)-4,5-dihydroxy-2,3-pentanedione (DPD), starting from commercial methyl (S)-(-)-2,2-dimethyl-1,3-dioxolane-4-carboxylate. DPD is the precursor of autoinducer (AI)-2, the proposed signal for bacterial interspecies communication. AI-2 is synthesized by many bacterial species in three enzymatic steps. The last step, a LuxS-catalyzed reaction, leads to the formation of DPD, which spontaneously cyclizes into AI-2. AI-2-like activity of the synthesized molecule was ascertained by the Vibrio harveyi bioassay. To further validate the biological activity of synthetic DPD and to explore its potential in studying DPD (AI-2)-mediated signaling, a Salmonella typhimurium luxS mutant was constructed. Expression of the AI-2 regulated lsr operon can be rescued in this luxS mutant by addition of synthetic DPD or genetic complementation. Biofilm formation by S. typhimurium has been reported to be defective in a luxS mutant, and this was confirmed in this study to test DPD for chemical complementation. However, biofilm formation of the luxS mutant cannot be restored by addition of DPD. In contrast, introduction of luxS under control of its own promoter complemented biofilm formation. Further results demonstrated that biofilm formation of the luxS mutant cannot be restored with luxS under control of the strong nptII promoter. This indicates that altering the intrinsic promoter activity of luxS affects Salmonella biofilm formation. Conclusively, we synthesized biologically active DPD. Using this chemical compound in combination with genetic approaches opens new avenues in studying AI-2-mediated signaling.
Cluster in High Dimensional Data to Detect Outlier

: In computer world data should be secured. To find deviated data or fraud in data some techniques are introduced and that method is nothing but Outlier Detection. , it helps to improve find out frauds and intruders. Outlier detection techniques are used for batch system also but for huge data we have to more careful to find such type of data. So, to overcome this over sampling principle component analysis is used. By using Principal Component Analysis (PCA), it is helpful to find Outlier. In this system ouraim to detect the presence of Outlier from a large amount of data using an online updating method. As we are using Oversampling Principal Component analysis (osPCA), there is no need to store data matrix or covariance matrix each time and thus approach is to find anomalies in online data stream or large amount of data problems. In our proposed system we capture only UDP packets will include. Along with this we are proposing algorithm for clustering
Lactate and pyruvate concentrations in capillary blood from newborns

Using high pressure liquid chromatography on strong cation exchange column, we analyzed capillary blood from 141 healthy full‐term newborns for lactate and pyruvate concentrations. Total range of lactate was 367–3245 μmol/l and reference interval (mean ± 2 SD) was 260–2212 μmol/l. Total range of pyruvate was 10–141 μmol/l and reference interval (10th/90th percentile) was 12–71μmol/l.
Feature selection analysis of WorldView-II data for similar urban objects distinction

Feature selection methods have recently become very attractive to remote sensing researches as new object-based image analysis systems have made available tens or even hundreds of spectral, textural and geometrical features to be used in classification routines. The aim of this study is to investigate, based on different feature selection algorithms, whether the additional bands of the WorldView II sensor are indeed helpful for the discrimination of similar urban targets.
A Comparison of the Pulmonary Inflammatory Potential of Different Components of Yeast Cell Wall

1→3-β-Glucan has been associated with pulmonary inflammation induced by exposure to fungal or yeast cell wall dust. 1→3-β-Glucan is the major cell wall component of yeast or fungi. However, the yeast cell wall contains several other components besides 1→3-β-glucans, such as mannan and chitin. Few studies evaluated the contribution of these other cell wall components to pulmonary inflammation. The present study compares a crude particulate yeast cell wall preparation (zymosan A) to purified yeast glucan, purified yeast glucan mannan, or purified yeast glucan chitin particles for their potency to induce mouse pulmonary inflammation after in vivo exposure. Mannan is the second most abundant polysaccharide in the yeast cell wall, whereas chitin content is a minor component. The results show that pulmonary injury is mediated by both chitin and 1→3-β-glucan and to a lesser degree by mannan. There is also evidence that zymosan is more potent than purified 1→3-β-glucan alone. Evidence indicates that 1→3-β-glucan is the major inflammatory component in yeast and fungal cell walls.
Caring for People at the End of Life: Iranian Oncology Nurses' Experiences

Aim: To explore the meaning of Iranian oncology nurses' experiences of caring for people at the end of life. Materials and Methods: A phenomenological hermeneutic approach was applied. Fifteen nurses working in oncology units were interviewed in 2007 regarding their experiences of caring for people at the end of life. Results: Participants experienced caring for people at the end of life as sharing space and time to be lost within an organizational context. This main theme was divided into three subthemes including being attentive to the dying persons and their families, being cared for by the dying persons and their families, and being faced with barriers. Conclusion: The study suggests that the nurses' success in caring for people at the end of life is reliant on their interpersonal caring relationship. Facilitating such relationship requires the establishment of palliative care unit, incorporation of palliative care into undergraduate nursing studies, and cultural preparation through public education.