Miracle-dz/UniFAR-FTUs huggingface dataset:
Models Applied in Stock Market Prediction: A Literature Survey

Stock market prices are intrinsically dynamic, volatile, highly sensitive, nonparametric, nonlinear, and chaotic in nature, as they are influenced by a myriad of interrelated factors. As such, stock market time series prediction is complex and challenging. Many researchers have been attempting to predict stock market price movements using various techniques and different methodological approaches. Recent literature confirms that hybrid models, integrating linear and non-linear functions or statistical and learning models, are better suited for training, prediction, and generalisation performance of stock market prices. The purpose of this review is to investigate different techniques applied in stock market price prediction with special emphasis on hybrid models.
Analysis of subsynchronous control interactions in DFIG-based wind farms: ERCOT case study

In this paper sub-synchronous control interactions (SSCI) in doubly-fed induction generator (DFIG) based wind farms are studied. The SSCI problem has come into prominence since the Electric Reliability Council of Texas (ERCOT) event of 2009, where a faulted line and subsequent outage in the network caused a large DFIG wind farm to become radially connected to the series compensation network, resulting in rapidly increasing sub-synchronous frequency oscillations leading to damage to both the series capacitor and the wind turbine. Therefore, in this paper, the part of the power grid in south Texas that experienced the SSCI in 2009 is considered as a case study. Using eigenvalue analysis on this network the main parameters contributing to the SSCI problem are identified. Finally, a SSCI damping controller (SSCIDC) is designed for this system using observed state feedback controller.
Application of phasor plot and autofluorescence correction for study of heterogeneous cell population

Abstract. Protein-protein interactions in cells are often studied using fluorescence resonance energy transfer (FRET) phenomenon by fluorescence lifetime imaging microscopy (FLIM). Here, we demonstrate approaches to the quantitative analysis of FRET in cell population in a case complicated by a highly heterogeneous donor expression, multiexponential donor lifetime, large contribution of cell autofluorescence, and significant presence of unquenched donor molecules that do not interact with the acceptor due to low affinity of donor-acceptor binding. We applied a multifrequency phasor plot to visualize FRET FLIM data, developed a method for lifetime background correction, and performed a detailed time-resolved analysis using a biexponential model. These approaches were applied to study the interaction between the Toll Interleukin-1 receptor (TIR) domain of Toll-like receptor 4 (TLR4) and the decoy peptide 4BB. TLR4 was fused to Cerulean fluorescent protein (Cer) and 4BB peptide was labeled with Bodipy TMRX (BTX). Phasor displays for multifrequency FLIM data are presented. The analytical procedure for lifetime background correction is described and the effect of correction on FLIM data is demonstrated. The absolute FRET efficiency was determined based on the phasor plot display and multifrequency FLIM data analysis. The binding affinity between TLR4-Cer (donor) and decoy peptide 4BB-BTX (acceptor) was estimated in a heterogeneous HeLa cell population.
Frequency and mitotic heritability of epimutations in Schistosoma mansoni

Schistosoma mansoni is a parasitic platyhelminth responsible for intestinal bilharzia. It has a complex life cycle, infecting a freshwater snail of the Biomphalaria genus, and then a mammalian host. Schistosoma mansoni adapts rapidly to new (allopatric) strains of its intermediate host. To study the importance of epimutations in this process, we infected sympatric and allopatric mollusc strains with parasite clones. ChIP‐Seq was carried out on four histone modifications (H3K4me3, H3K27me3, H3K27ac and H4K20me1) in parallel with genomewide DNA resequencing (i) on parasite larvae shed by the infected snails and (ii) on adult worms that had developed from the larvae. No change in single nucleotide polymorphisms and no mobilization of transposable elements were observed, but 58–105 copy number variations (CNVs) within the parasite clones in different molluscs were detected. We also observed that the allopatric environment induces three types of chromatin structure changes: (i) host‐induced changes on larvae epigenomes in 51 regions of the genome that are independent of the parasites’ genetic background, (ii) spontaneous changes (not related to experimental condition or genotype of the parasite) at 64 locations and (iii) 64 chromatin structure differences dependent on the parasite genotype. Up to 45% of the spontaneous, but none of the host‐induced chromatin structure changes were transmitted to adults. In our model, the environment induces epigenetic changes at specific loci but only spontaneous epimutations are mitotically heritable and have therefore the potential to contribute to transgenerational inheritance. We also show that CNVs are the only source of genetic variation and occur at the same order of magnitude as epimutations.
An effective fault detection technique for a quasi-Z-Source based grid-tied PV system

In high performance grid-connected PV systems, deploying a power electronics converter capable of operating effectively in the presence of any single point of failure is essential. One of the main advantages of Cascaded H-Bridge (CHB) Multilevel Inverter (MLI) is the modularity. Moreover, the association of a quasi Z-Source (qZS) network with a CHB MLI was deeply investigated in the last decade for grid-tied PV systems. This structure is considered as a single-stage DC/AC topology having the capability of boosting the DC input voltage with high-quality multilevel AC voltage, independent DC-link voltage compensation, and control of the power transfer with high reliability. Thus, this topology suits well fault-tolerant PV systems due to the modularity of the CHB inverter and the flexibility of the qZS network in controlling the DC-link voltage even under faults. However, the effective operation of the MLI needs a continuous monitoring to detect abnormalities and faults to provide more effective and less interrupted energy supplies. The Exponentially Weighted Moving Average (EWMA) method has been proved to be among the most effective univariate techniques to detect small and moderate faults. Thus, this paper presents an effective EWMA based fault detection technique for a 3-phase 3-cell qZS-CHB MLI. Simulation results show the effectiveness of the proposed technique in detecting faults compared to the conventional Generalized Likelihood Ratio Test (GLRT) technique.
The Possible Interconnectedness of Religious Populism, Stigmatization, Dehumanization and Hate Crimes and an Evaluation on Muslims in Russia

Populist telkinler cok uzun suredir halklari etkilemekte, kuresel ve kuresel-yerel politikalari sekillendirmektedir. Fakat gunumuzde, populizmin etkileri artan bicimde yerel politikalar ve uluslararasi iliskilerde onemli roller ustlenmektedir. Bu arastirma dini populizm, damgalama, insandisilastirma, nefret suclari ve insan haklari ihlallerine odaklanmaktadir. Bu arastirma sonucunda soz konusu fenomenler arasinda muhtemel baglantililiklar oldugu onerilmektedir. Bu muhtemel baglantililik, soz konusu fenomenlerin onemini arttirmaktadir; cunku en temel ihlaller dahi vahim insan haklari ihlallerine sebep olabilecektir. Dini populizm ogretilerinin toplumsal arindirma veya insanliga karsi islenen suclar gibi vahim sonuclara yol acabilecegi hatirlatilmistir. Ayrica, Rusya’da yasayan Muslumanlarin haklari ve onlarin icinde yasadiklari guncel sartlar hakkindaki cesitli argumanlar incelenmistir. Son olarak bilgi ve algi operasyonlarinin onemi ve ilgili stratejiler vurgulanmistir.
Involvement of the Small GTPase Rho in Integrin-mediated Activation of Mitogen-activated Protein Kinase*

Engagement and clustering of integrins triggers a number of intracellular signaling events, including activation of the mitogen-activated protein (MAP) kinases Erk1 and Erk2. To investigate the mechanism by which integrins mediate the activation of MAP kinases upon binding of NIH 3T3 cells to fibronectin, we assessed the effects of both inhibiting and activating the small GTPase Rho. We observed that inhibition of Rho by the Rho-specific inhibitor C3 exoenzyme or by a dominant negative Rho A (RhoN19) inhibited MAP kinase activation. Conversely, activation of Rho by expression of an activated Rho A mutant (RhoQ63L), or the Rho-specific guanine nucleotide exchange factor lbc, enhanced and partially mimicked activation of Erk2 by plating on fibronectin. These results therefore show that Rho is involved in the integrin-dependent activation of MAP kinase.
Simultaneously determining Young's modulus, coefficient of thermal expansion, Poisson ratio and thickness of thin films on silicon wafer

A method is demonstrated to simultaneously determine Young's modulus (E), coefficient of thermal expansion (/spl alpha/), Poisson ratio (v), and thickness (t) of thin films on a silicon wafer. A digital phase-shifted reflection moire (DPRM) technique was adopted to record the warpage slope of the film/wafer composites under temperature change. These data were used to compare with the ANSYS analysis, and a genetic algorithm (GA) was employed to search for the optimal mechanical parameters of the films. In the first experiment, 1.20-/spl mu/m thick copper was sputtered on a 4-inch silicon wafer. While the determined film thickness was in good agreement with the measured value, the deviation in E, /spl alpha/ and v was significant. The micro-structural difference between the bulk material and the thin film, and oxidation on the film surface were considered to be the two major causes to this deviation. In order to verify the determined mechanical parameters of this 1.2-/spl mu/m Cu film, an additional 2.4-/spl mu/m Cu film was sputtered on the Cu/Si wafer and the determined mechanical parameters of this additional Cu film were identical to the data obtained in the 1.2-/spl mu/m film, which demonstrated the validity of the developed method.
The Quorum-Sensing Molecule Autoinducer 2 Regulates Motility and Flagellar Morphogenesis in Helicobacter pylori

ABSTRACT The genome of the gastric pathogen Helicobacter pylori contains a homologue of the gene luxS, which has been shown to be responsible for production of the quorum-sensing signal autoinducer 2 (AI-2). We report here that deletion of the luxS gene in strain G27 resulted in decreased motility on soft agar plates, a defect that was complemented by a wild-type copy of the luxS gene and by the addition of cell-free supernatant containing AI-2. The flagella of the luxS mutant appeared normal; however, in genetic backgrounds lacking any of three flagellar regulators—the two-component sensor kinase flgS, the sigma factor σ28 (also called fliA), and the anti-sigma factor flgM—loss of luxS altered flagellar morphology. In all cases, the double mutant phenotypes were restored to the luxS + phenotype by the addition of synthetic 4,5-dihydroxy-2,3-pentanedione (DPD), which cyclizes to form AI-2. Furthermore, in all mutant backgrounds loss of luxS caused a decrease in transcript levels of the flagellar regulator flhA. Addition of DPD to luxS cells induced flhA transcription in a dose-dependent manner. Deletion of flhA in a wild-type or luxS mutant background resulted in identical loss of motility, flagella, and flagellar gene expression. These data demonstrate that AI-2 functions as a secreted signaling molecule upstream of FlhA and plays a critical role in global regulation of flagellar gene transcription in H. pylori.
Analytical Modeling and Implementation of a Coaxially Wound Transformer With Integrated Filter Inductance for Isolated Soft-Switching DC–DC Converters

In this paper, we propose an approach for integrating a series filter inductance in a coaxially wound transformer (CWT) as a potential alternative to conventional solenoidally wound transformers (SWT) for high-power isolated soft-switching dc–dc converters. The critical elements that determine the size and the performance of soft-switching dc–dc converters are the isolation transformer and the filter elements. While conventional SWTs using a stray magnetic field as a filter inductance often suffer from a considerably increased loss, heat congestion, and electromagnetic interference, a CWT is rarely affected by high frequency and fringing effects. The desired properties are still valid while the required filter inductance is fully integrated with an isolation transformer using the proposed method. In addition, the evenly distributed magnetic fields in a concentric geometry enable accurate electrical and mechanical analysis and a specific application-oriented design. In this paper, the operating principles, design procedure, and loss modeling of a CWT with an integrated filter inductance are introduced. Its functionality and suitability for high-frequency applications were proven by theoretical analysis and experiments. A prototype transformer with an integrated inductance 4 mH was facilitated and evaluated in a 15 kV-SiC mosfet-based 6 k–400 Vdc stage for a solid-state transformer of up to 6.5 kW at a switching frequency of 20 kHz.
Systemic Therapy of Cholangiocarcinoma

Background: Cholangiocarcinoma (CC) is the second most common primary malignant liver disease. During the last decades, various novel therapies have been introduced in the field of oncology; nevertheless, the number of treatment options for CC is still limited. Methods: In this article, current palliative chemotherapy concepts as well as new drug therapies are outlined. Results: Gemcitabine and cisplatin are the standard treatment of care for patients with inoperable CC. Second-line chemotherapy is not standardized yet and is dependent on the first-line compounds. Antibodies against VEGFR and EGFR showed mixed or negative results. New molecular systemic treatments are not established yet. Conclusion: Many clinical trials are still ongoing and new therapeutic strategies, including immunotherapies, are under active investigation.
Fracture Assessment Tool Risk Scores in Bone Density Reports Do Not Change Physician Prescribing Behavior for Osteoporosis

Introduction:Prevention of osteoporotic fractures is desirable to decrease morbidity, mortality and health care costs. The World Health Organization Fracture Assessment Tool (FRAX) enhances physician treatment decisions by combining epidemiologic fracture risk calculations with bone density. The authors sought to determine the effect of reporting FRAX results and treatment recommendations in bone density reports on clinician prescribing behavior. Methods:Retrospective review of adherence to treatment recommendations for 368 osteopenic patients at a VA Medical Center 7 months before (pre-FRAX) and after (post-FRAX) inclusion of fracture risk assessment data into the dual energy X-ray absorptiometry. Only osteopenic patients were included (T score: −1.0<T<−2.5). Demographic information, provider type, dual energy X-ray absorptiometry results and the decision to prescribe a Food and Drug Administration-approved drug within 6 months of the report were captured. Data were analyzed using &khgr;2 test. Results:There were 178 pre-FRAX and 192 post-FRAX patients. In the pre-FRAX group, 14.8% of osteopenic patients were treated based on clinical judgment. In the post-FRAX group, FRAX identified 63 high-risk osteopenic patients for treatment. Of these, only 31.7% were treated. Eleven of the 129 osteopenic patients not recommended for treatment were treated. There was no difference in physician decision to treat or seek subspecialty consultation before and after reporting of FRAX data (14.8% pre-FRAX versus 16.2% post-FRAX; P = 0.682). Conclusions:Despite the potential benefit of using FRAX, the authors found that: (1) prescribing behavior was not influenced by including FRAX in the bone density report and (2) increased education of FRAX fracture risk assessment is needed.
Saddle-point instability in models of chiral-symmetry breaking.

We examine the stability of models of chiral-symmetry breaking based on truncated Schwinger-Dyson equations. We incorporate renormalization-group improvement through a running coupling constant. We confirm in a specific model that all chiral-symmetry-breaking solutions correspond to saddle points of the effective-potential functional. The instability can be traced to momentum scales in the range from intermediate to infrared. The region from intermediate to ultraviolet gives a completely consistent picture of the energetics of candidate vacuum states. Further systematic patterns of solutions are presented.
Meta‐analysis: levamisole improves the immune response to hepatitis B vaccine in dialysis patients

Background Patients undergoing maintenance dialysis often fail to mount protective antibodies to hepatitis B virus surface antigen (HBsAg) following vaccination against hepatitis B virus (HBV). Some authors have suggested that levamisole improves immune response to HBV vaccine in dialysis population. However, consistent information on this issue does not exist.
“Late” macroendosomes and acidic endosomes in vertebrate motor nerve terminals

Activity at the vertebrate nerve—muscle synapse creates large macroendosomes (MEs) via bulk membrane infolding. Visualized with the endocytic probe FM1‐43, most (94%) of the ∼25 MEs/terminal created by brief (30‐Hz, 18‐second) stimulation dissipate rapidly (∼1 minute) into vesicles. Others, however, remain for hours. Here we study these “late” MEs by using 4D live imaging over a period of ∼1 hour after stimulation. We find that some (51/398 or 13%) disappear spontaneously via exocytosis, releasing their contents into the extracellular milieu. Others (at least 15/1,960 or 1%) fuse or closely associate with a second class of endosomes that take up acidophilic dyes (acidic endosomes [AEs]). AEs are plentiful (∼47/terminal) and exist independent of stimulation. Unlike MEs, which exhibit Brownian motion, AEs exhibit directed motion (average, 83 nm/sec) on microtubules within and among terminal boutons. AEs populate the axon as well, where movement is predominantly retrograde. They share biochemical and immunohistochemical markers (e.g., lysosomal‐associated membrane protein [LAMP‐1]) with lysosomes. Fusion/association of MEs with AEs suggests a sorting/degradation pathway in nerve terminals wherein the role of AEs is similar to that of lysosomes. Based on our data, we propose that MEs serve as sorting endosomes. Thus their contents, which include plasma membrane proteins, vesicle proteins, and extracellular levels of Ca2+, can be targeted either toward the reformation and budding of synaptic vesicles, toward secretion via exocytosis, or toward a degradation process that utilizes AEs either for lysis within the terminal or for transport toward the cell body. J. Comp. Neurol. 520:4275–4293, 2012. © 2012 Wiley Periodicals, Inc.
Determination of the lactate breakpoint during incremental exercise in horses adapted to dietary corn oil.

OBJECTIVE To determine lactate breakpoint of horses and test for effects of training and dietary supplementation with corn oil on that breakpoint. ANIMALS 7 healthy Arabian horses. PROCEDURES Horses received a control diet (n = 4) or a diet supplemented with 10% corn oil (4). A training program, which comprised two 5-week conditioning periods with 1 week of rest, was initiated. Submaximal incremental exercise tests (IET) were conducted before the first and after both conditioning periods. Blood samples for determination of blood lactate and plasma glucose concentrations were collected 1 minute before IET and during the 15 seconds immediately preceding each speed change. Data collected were fit to one- and two-slope broken-line models and an exponential model. RESULTS Good fits were obtained by application of the broken-line models (adjusted R2 > 0.92) to blood lactate concentration versus speed curves. Lactate breakpoints increased 41% after training. After training, slope 2 and peak blood lactate concentrations were greater in the corn oil group, compared with controls. Mean blood lactate concentration at the breakpoint was not affected by training or diet. Plasma glucose concentration versus speed curves also fit the broken-line models, and glucose breakpoints preceded lactate breakpoints by approximately 1 m/s in the second and third IET. CONCLUSIONS AND CLINICAL RELEVANCE Lactate breakpoints can be determined for horses, using blood lactate concentration versus speed curves generated during submaximal IET and may be useful for assessing fitness and monitoring training programs in equine athletes.
Imaging of cross-sectional elasticity in short-axis plane of arterial wall by transcutaneous ultrasound

We have developed the phased tracking method for measuring the minute change in thickness during one heartbeat and the elasticity of the arterial wall with transcutaneous ultrasound. When this method is applied to a plane perpendicular to the axis of the artery (short-axis plane) using a linear-type probe, only an ultrasonic cam which passes through the center of the artery coincides with the direction of the change in thickness. At other beam positions, the wall motion cannot be accurately tracked because the direction of wall expansion slips of the beam. To obtain the cross-sectional image of elasticity in the short-axis plane using transcutaneous ultrasound, in this paper, the directions of ultrasonic beams are designed so that each beam always passes through the center of the artery thus they always coincide with the direction of the wall expansion. In basic experiments, the accuracy in elasticity measurement was evaluated using a silicone rubber tube. In in vitro experiments using an extracted human femoral artery, the measured elasticity image was compared with the pathological image. In in vivo experiments, the minute change in wall thickness was measured along each ultrasonic beam. and the cross-sectional image of elasticity was obtained in the short-axis plane with transcutaneous ultrasound.
Design and evaluation of oral nanoemulsion drug delivery system of mebudipine

Abstract A nanoemulsion drug delivery system was developed to increase the oral bioavailability of mebudipine as a calcium channel blocker with very low bioavailability profile. The impact of nano-formulation on the pharmacokinetic parameters of mebudipine in rats was investigated. Nanoemulsion formulations containing ethyl oleate, Tween 80, Span 80, polyethylene glycol 400, ethanol and deionized water were prepared using probe sonicator. The optimum formulation was evaluated for physicochemical properties, such as particle size, morphology and stability. The particle size of optimum formulation was 22.8 ± 4.0 nm. Based on the results of this study, the relative bioavailability of mebudipine nanoemulsion was enhanced by about 2.6-, 2.0- and 1.9-fold, respectively, compared with suspension, ethyl oleate solution and micellar solution. In conclusion, nanoemulsion is an interesting option for the delivery of poorly water soluble molecules, such as mebudipine.
Off-Resonance Low-Pressure Operation of Lorentz Force MEMS Magnetometers

This paper demonstrates bandwidth extension for Lorentz force microelectromechanical systems magnetometers operated at a frequency slightly lower than the mechanical resonance. This off-resonance mode of operation also minimizes the critical tradeoff between maximum sensing bandwidth and minimum measurable field, enabling low-pressure operation and the associated resolution improvement. The experimental verification is obtained using two identical devices packaged at two different pressures and tested with a suitable low-noise board-level electronics. The first device, packaged at 1 mbar, has a (mechanical) sensing bandwidth of ~50 Hz, and a resolution per unit bandwidth and driving current of 290 nT · mA/√Hz. With the second device, packaged at 0.25 mbar and operated off-resonance, roughly twice better resolution (160 nT · mA/√Hz) and four times larger bandwidth (>200 Hz) are obtained.