Miracle-dz/UniFAR-FTUs huggingface dataset:
Catch You as I Can: Indoor Localization via Ambient Sound Signature and Human Behavior

Localization, together with scene and human activity sensing, provides primitive and essential information for upper layer mobile applications. In this paper, we present a novel indoor localization system. We not only make rough localization by the use of the Wi-Fi/GSM signal, but also use the microphone of the smartphone to deeply sense the environment. By analyzing the ambient sound and speech after voice activity detection, we can know exactly if the user appears somewhere and does something at the regulated time according to his or her schedule. The ambient noise is used to identify the ambient scene, and we can deduce the users' current activities by the user's speech sensing. Conclusively, accurate localization and the status information on the user are made by synthesizing the above sound sensing information. And, according to the prestored schedule in the backend server, the location and sensing information are returned to the monitor who wants to know where the user is and what he is doing. We prototype the system on Android mobile phones and evaluate the system comprehensively with data collected from 61 different indoor sites by 100 volunteers over a two-month period of experiments by employing different phone models. We believe this is a novel approach to indoor localization, holding promise of real-world deployment.
Cloning and Characterization of HuR, a Ubiquitously Expressed Elav-like Protein (*)

The neuronal-specific Elav-like proteins (HuD, Hel-N, and HuC) contain three RNP-type concensus motifs and bind to AU-rich elements. We have identified and cloned a fourth member of this family (HuR) that is expressed in a wide variety of cell types. The purified recombinant protein binds avidly to the AU-rich element in c-fos and interleukin-3 mRNAs. In the case of the c-fos AU-rich element, HuR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Mutational analysis has shown that all three AU motifs are required for maximal binding.
Analysis characteristics and optimal design procedure of half-bridge LLC loaded resonant converter

This paper presents theoretical analysis characteristics and optimal design procedure of half-bridge LLC loaded resonant converter. This theoretical analysis had been verified with simulation work by using MATLAB/Simulink 2011. The converter design is aim to achieve Zero-Voltage-Switching (ZVS) for low applications. The converter designed is operated below resonant frequency with specified load at 30mW and 3V-5V.
Three splicing variants of tomosyn and identification of their syntaxin-binding region.

We have recently isolated a neural tissue-specific syntaxin-1-binding protein, named tomosyn, which is capable of dissociating Munc18/n-Sec1/rbSec1 from syntaxin-1 to form a 10S tomosyn complex, an intermediate complex converted to the 7S SNARE complex. We isolated here two splicing variants of tomosyn: one had 36 amino acids (aa) insertion and another had 17 aa deletion. We named original one m-tomosyn, big one b-tomosyn, and small one s-tomosyn. s-Tomosyn as well as m-tomosyn was mainly expressed in brain whereas b-tomosyn was ubiquitously expressed. All the isoforms bound to syntaxin-1, but not to syntaxin-2, -3, or -4, and had a region highly homologous to VAMP, another syntaxin-binding protein. This region was necessary but not sufficient for high-affinity binding of tomosyn to syntaxin-1.
Poly[[diaquabis(μ2-4,4′-bipyridyl)iron(II)] bis{2-[(3-carboxypyridin-2-yl)disulfanyl]nicotinate}]

In the title compound, {[Fe(C10H8N2)2(H2O)2](C12H7N2O4S2)2}n, synthesized by hydrothermal reaction, the 4,4′-bipyridyl ligands (one with symmetry 2, one with symmetry ) connect Fe2+ cations, forming a cationic layer parallel to (001). The coordination of the Fe2+ cation (site symmetry 2) is octahedral, with four N atoms from four 4,4′-bipyridyl ligands and O atoms from two trans water molecules. Adjacent layers are linked with each other by intermolecular O—H⋯O hydrogen bonds, forming a three-dimensional supramolecular structure. Parts of the nicotinic acid derivative are equally disordered over two sets of sites.
Evaluation of the aerosol indirect effect using satellite, chemical transport model, and aircraft data during ICARTT

Anthropogenic pollution is known to increase the albedo of shallow layer clouds by increasing concentrations of droplets and decreasing droplet radii (Twomey, 1974). Smaller droplets are less effective at producing precipitation sized drops through the collision-coalescence process, so that pollution may also lead to increased cloud lifetime and cloud cover (Albrecht, 1989). Conversely, the absorption of solar radiation by haze may reduce fractional cloudiness (Ackerman et al. 2000). The magnitudes of these aerosol "indirect effects" have substantial uncertainties (International Panel on Climate Change (IPCC) 2001). Recently, numerous studies have used satellite data to investigate aerosol indirect effects on both regional and global scales (e.g. Nakajima et al., 2001; Sekiguchi et al. 2003, Quaas et al., 2004; Matheson et al., 2005; Kaufman et al., 2005). However, a drawback in each of these studies is that passive satellite methods are unable to measure aerosols exactly collocated with clouds, requiring instead aerosol retrievals be made in regions directly adjacent to clouds. An assumption is then made that aerosol concentrations are homogeneous throughout the cloudy and cloud-free regions (e.g. Quaas et al., 2006). A possible concern with this approach is that because cloud properties depend foremost on meteorology, and almost by definition, the cloud and aerosol retrievals are derived from different meteorological regimes. An alternate strategy for satellite-based assessment of the indirect effect is to use high temporal
Aquachlorido{6,6′-dimethoxy-2,2′-[ethane-1,2-diylbis(nitrilomethanylylidene)]diphenolato-κ2 O 1,N,N′,O 1′}cobalt(III) dimethylformamide monosolvate

In the title compound, [Co(C18H18N2O4)Cl(H2O)]·C3H7NO, the CoIII ion is six-coordinated by a tetradentate 6,6′-dimethoxy-2,2′-[ethane-1,2-diylbis(nitrilomethanylylidene)]diphenolate ligand, with a chloride ion and an aqua ligand in the apical positions. The compound crystallized as a dimethylformamide (DMF) monosolvate. In the crystal, complex molecules are linked via O—Hwater⋯O hydrogen bonds to form a dimer-like arrangement. These dimers are linked via a C—H⋯Cl interaction, and the DMF molecule is linked to the complex molecule by C—H⋯O interactions.
Bit flipping and time to recover

We call 'bits' a sequence of devices indexed by positive integers, where every device can be in two states: 0 (idle) and 1 (active). Start from the 'ground state' of the system when all bits are in 0-state. In our first binary flipping (BF) model the evolution of the system behaves as follows. At each time step choose one bit from a given distribution P on the positive integers independently of anything else, then flip the state of this bit to the opposite state. In our second damaged bits (DB) model a 'damaged' state is added: each selected idling bit changes to active, but selecting an active bit changes its state to damaged in which it then stays forever. In both models we analyse the recurrence of the system's ground state when no bits are active. We present sufficient conditions for both the BF and DB models to show recurrent or transient behaviour, depending on the properties of the distribution P. We provide a bound for fractional moments of the return time to the ground state for the BF model, and prove a central limit theorem for the number of active bits for both models.
Histologic changes after vertebroplasty.

BACKGROUND Vertebroplasty with use of polymethylmethacrylate cement is gaining popularity in the treatment of some specific painful lesions of the spine. It remains unclear, however, what possible side effects this type of cement might have upon the vertebral body. We performed a histologic and radiographic analysis of the end plate and disc to determine whether there was a difference between vertebroplasty with polymethylmethacrylate cement and vertebroplasty with calcium phosphate cement in the surrounding tissue of the goat spine. Furthermore, we assessed whether a defect in the end plate, simulating end-plate fracture and allowing for direct contact of cement with disc tissue, had any effect on end-plate or disc degeneration. METHODS Twenty-four mature goats were divided between two follow-up periods (six weeks and six months). All animals underwent a bilateral transpedicular vertebroplasty at two lumbar levels, where one of the following treatments was applied: vertebroplasty with calcium phosphate cement with or without an end-plate defect, and vertebroplasty with polymethylmethacrylate cement with or without an end-plate defect. The effect of the various treatments on the integrity of the intervertebral disc, end plate, and surrounding tissue was examined with semiquantitative histologic analysis and radiography. RESULTS No sign of disc or end-plate degeneration was seen in any of the analyzed sections. The mean disc height did not decrease from the postoperative period to the time that the animals were killed in any group, thereby supporting the histologic findings. A mild inflammatory reaction was found in four vertebral bodies in the polymethylmethacrylate groups only. CONCLUSIONS Calcium phosphate cement and polymethylmethacrylate cement both seem to be adequate bone-void fillers in terms of biological behavior in the vertebral body.
The peculiar velocity and temperature profile of galaxy clusters

Dynamical parameters like average velocity dispersion and temperature profile of galaxy clusters are determined using the theory of quasi-equilibrium thermodynamics. The calculated results of velocity dispersion show a good agreement between theory and simulations with the results of velocity dispersion from Abdullah et al. An adaptive mesh refinement grid-based hybrid code has been used to carry out the simulations. Our results indicate that the average velocity dispersion profile of 20 Abell galaxy clusters falls in the range of 500 — 1000 km s−1 and their temperature profile is of the order of 107 to 108 K calculated on the basis of kinetic theory. The data in the plot show a significant contribution from gravitating particles clustering together in the vicinity of the cluster center and beyond a certain region this velocity dies out and becomes dominated by the Hubble flow due to which all the galaxy clusters in an expanding universe participate in Hubble expansion.
Granulocyte colony-stimulating factor following peripheral-blood progenitor-cell transplant in non-Hodgkin's lymphoma.

PURPOSE To compare the hematologic recovery after high-dose chemotherapy and circulating peripheral-blood progenitor-cell (PBPC) transplant between patients who received recombinant human granulocyte colony-stimulating factor (G-CSF) (treated group) and those who did not (control group). PATIENTS AND METHODS From December 1992 through June 1994, two sequential and consecutive cohorts of 20 patients each with histologically proven non-Hodgkin's lymphoma (NHL) received high-dose chemotherapy (carmustine [BCNU], cytarabine [Ara-C], etoposide and melphalan [BEAM]) followed by PBPC transplant. The first 20 patients were treated with G-CSF (5 micrograms/kg/d) after PBPC administration. Since the time of platelet and leukocyte recovery in this group was short (< 15 days), with a narrow standard deviation from the mean value, the last 20 patients were not given G-CSF. Hematologic recovery, number of febrile days, rate of documented infections, number of hospital days, duration of gastrointestinal complications, platelet and RBC transfusions, and antibiotic requirements were compared in the two groups. RESULTS The two groups of patients were comparable according to disease status, histology, stage, bulky disease bone marrow involvement, elevated lactate dehydrogenase (LDH) level, and median number of infused CD34+ cells and colony-forming units granulocyte-macrophage (CFU-GM). The median time to reach 0.5 x 10(9)/L and 1.0 x 10(9)/L neutrophils was 2 days shorter in G-CSF group, but this difference was not statistically significant. The median times to reach 20 x 10(9)/L and 50 x 10(9)/L platelets were, respectively, 10 and 14 days in the G-CSF group and 11 and 16 days in the control group, but again this was not statistically significant. Moreover, when considering clinically relevant end points including the number of documented infections and antibiotic requirements, platelet transfusions, gastrointestinal toxicity, and days of hospitalization, no differences were demonstrated between the two groups. CONCLUSIONS Provided an optimal dose of circulating progenitors is infused, NHL patients transplanted with PBPC do not benefit by the administration of hematopoietic growth factors.
MR-SFAMA: A novel MAC protocol for underwater acoustic sensor networks

Underwater acoustic channel has some special properties: large propagation delay, limited bandwidth and poor quality of the physical link. The design of MAC protocol for underwater acoustic sensor networks is more difficult than terrestrial wireless networks. Because of the large propagation delay, the MAC protocol of the terrestrial wireless networks is not suitable for the underwater acoustic sensor networks. This paper proposes a novel MAC protocol based on the SFAMA protocol. The protocol improves throughput by using a new multiple reception handshaking mechanism. The handshaking mechanism allows a receiving node receives multiple data packets simultaneously. Simulation results show that this protocol achieves a higher throughput and fairness than the SFAMA protocol.
Recent developments in drug resistance mechanism in chronic myeloid leukemia: a review

A revolution in medical science was marked with the advent of imatinib, a site‐specific drug for the management of patients with chronic myeloid leukemia (CML). Imatinib mesylate (also known as Glivec, Gleevec, STI‐571, CGP57148), an orally administered 2‐phenylaminopyrimidine derivative approved by FDA in 2001 for the treatment for CML, is highly effective in treating the early stages of CML, but remission induced in advanced phase was observed to be relatively short‐lived. The primary cause of resistance in patients with CML is the mutations in the BCR–ABL kinase domain. This review discusses the different mechanisms leading to imatinib resistance and various treatment options to over‐ride imatinib resistance.
[Rattus norvegicus as an indicator of circulation of Capillaria hepatica and Taenia taeniaeformis on a groceries trade center of Medellín, Colombia].

INTRODUCTION Rattus norvegicus, the Norway rat, plays a pivotal role in the maintenance and spread of several zoonotic bacterial, viral and parasitic pathogens of public health interest. The presence of helminthic infections near susceptible human populations can, under appropriate environmental conditions, become a risk factor for their transmission. OBJECTIVE Frequencies of infection were reported for Capillaria hepatica and larval forms of Taenia taeniaeformis in wild rats (R. norvegicus) captured in an urban area. MATERIALS AND METHODS Two hundred and fifty-four adult specimens of R. norvegicus were collected in an urban zone of Medellín, Colombia. The livers of 54 specimens that showed macroscopic hepatic lesions during necropsy were examined by conventional histopathology. RESULTS The frequency of infestation with C. hepatica was 20.1% (51/254). Six livers (2.4%) were also positive for larvae of T. taeniaeformis. Livers infested with C. hepatica exhibited adult or juvenile parasites and oval eggs with bipolar opercula, and were associated with mild to moderate multifocal granulomatous hepatitis with leucocyte infiltrate. Granulomatous lesions and calcified residual fibroses were found with eggs but without adult parasites. Those animals with cysticerci of T. taeniaeformis showed a high frequency of hepatic cysts containing larvae as well as inflammed and fibrotic lesions. CONCLUSION Zoonotic helminths circulate at high frequency in R. norvegicus that occur in urban environments. Further research about the distribution of these parasites will determine the level of health threat they present for susceptible human and domestic animal populations.
The β-Galactosidase (Escherichia coli) Reaction Is Partly Facilitated by Interactions of His-540 with the C6 Hydroxyl of Galactose*

β-Galactosidases with substitutions for His-540 were only poorly reactive with galactosyl substrates. However, the activity with substrates that were like galactose but did not have a C6 hydroxyl group was not decreased much as a result of such substitutions. The loss of transition state stabilization for galactosyl substrates as a result of substitution was between −15.4 and −22.8 kJ/mol but only between +0.34 and −6.5 for substrates that were identical to galactose but lacked the C6 hydroxyl. These findings indicate that an important function of His-540 is to aid in the stabilization of the transition state by forming a stable interaction with the C6 hydroxyl group. This suggestion was strengthened by the results of competitive inhibition studies showing that L-arabinolactone (a transition state analog inhibitor of β-galactosidase without a C6 hydroxymethyl group) was bound as well by the substituted enzymes as by wild type, whereas transition state analog inhibitors that contain C6 hydroxyls (L-ribose and D-galactonolactone) were bound much more poorly by the substituted enzymes than by the wild type enzyme. Substrate analog inhibitor studies showed that His-540 was also important for binding interactions with the C6 hydroxyl group of the ground (substrate) state. The activation by Mg2+ was the same for the substituted enzymes as for the wild type, and equilibrium dialysis showed that H540F-β-galactosidase bound Mg2+ as well as did normal β-galactosidase. The k2 and Ks values seem to have the same pH interactions as wild type enzyme, whereas the k3 interactions are affected differently by pH in the substituted enzymes than in the wild type enzyme. The rate of the “degalactosylation” reaction was affected more by substitutions for His-540 than was the rate of the “galactosylation” reaction. All three substituted β-galactosidases were less stable to heat than was wild type, but H540N-β-galactosidase was somewhat more stable than the other two substituted enzymes. There were some differences in activity and inhibitory properties that resulted from the different substitutions.
Prenatal Stress Induces High Anxiety and Postnatal Handling Induces Low Anxiety in Adult Offspring: Correlation with Stress-Induced Corticosterone Secretion

It is well known that the hypothalamo-pituitary-adrenal (HPA) axis is altered by early environmental experiences, particularly in the perinatal period. This may be one mechanism by which the environment changes the physiology of the animal such that individual differences in adult adaptative capabilities, such as behavioral reactivity and memory performance, are observable. To determine the origin of these behavioral individual differences, we have investigated whether the long-term influence of prenatal and postnatal experiences on emotional and cognitive behaviors in adult rats are correlated with changes in HPA activity. To this end, prenatal stress of rat dams during the last week of gestation and postnatal daily handling of rat pups during the first 3 weeks of life were used as two environmental manipulations. The behavioral reactivity of the adult offspring in response to novelty was evaluated using four different parameters: the number of visits to different arms in a Y-maze, the distance covered in an open field, the time spent in the corners of the open field, and the time spent in the open arms of an elevated plus-maze. Cognitive performance was assessed using a water maze and a two-trial memory test. Adult prenatally stressed rats showed high anxiety-like behavior, expressed as an escape behavior to novelty correlated with high secretion of corticosterone in response to stress, whereas adult handled rats exhibited low anxiety-like behavior, expressed as high exploratory behavior correlated with low secretion of corticosterone in response to stress. On the other hand, neither prenatal stress nor handling changed spatial learning or memory performance. Taken together, these results suggest that individual differences in adult emotional status may be governed by early environmental factors; however, perinatal experiences are not effective in influencing adult memory capacity.
Updated evidence in support of diet and exercise interventions in cancer survivors

Abstract Background. A growing body of evidence suggests that diet and exercise behaviors and body weight status influence health-related outcomes after a cancer diagnosis. This review synthesizes the recent progress in lifestyle interventions in light of current guidelines put forth by the American Cancer Society (ACS), the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and the American College of Sports Medicine (ACSM). Methods. The PubMed database was searched for terms of cancer survivor(s) or neoplasms/survivor, cross-referenced with MeSH terms of lifestyle, health behavior, physical activity, exercise, body weight, obesity, weight loss, diet, nutrition, and intervention studies and limited to randomized controlled trials (RCTs) that had retention rates exceeding 75%. Results. There has been an increase in the number and methodological rigor of the studies in this area, with 21 RCTs identified in the past three years. Results suggest that physical activity interventions are safe for cancer survivors and produce improvements in fitness, strength, physical function, and cancer-related psychosocial variables, whereas dietary interventions improve diet quality, nutrition-related biomarkers and body weight. Preliminary evidence also suggests that diet and exercise may positively influence biomarkers associated with progressive disease and overall survival (e.g., insulin levels, oxidative DNA damage, tumor proliferation rates). Discussion. The evidence base regarding health-related benefits of increased physical activity, an improved diet, and weight control continues to expand. Due to the large (and increasing) number of cancer survivors, more research is needed that tests the impact of lifestyle change on health-related outcomes in this population, especially research that focuses on high-reach, sustainable interventions that recruit diverse, representative samples to help increase the generalizability of findings to the population at large. Concurrent research also needs to address relative benefit in relation to various subpopulations as defined by phenotype, genotype, and/or exposures to treatment, and other lifestyle and environmental factors.