Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of dietary minerals on postmolt performance of laying hens

Four hundred and fifty Single Comb White Leghorn commercial layers (66-67 weeks-old) were housed 2 birds per cage for the molting procedure. The hens were divided into 5 treatment groups with 90 layers per treatment and 30 layers in each replicate per treatment group following completely randomized design. During molt period (2 Weeks), experimental birds were randomly assigned to five-treatment groups viz., A (15 ppm copper sulphate), B (20 ppm zinc oxide), C (20 ppm aluminium oxide), D (balanced layer diet without added minerals) and E (without induced molting as control). The birds in groups A, B, C and D were offered respective experimental diets at the rate of 30 g/bird except bird's in-group E (ad libitum) and lighting program was followed as 12L: 12D. During rest period (3 Weeks) the birds in groups A, B, C and D were given respective experimental diet at the rate of 50 g/bird for first 2 weeks of the rest period. rd During 3 week of rest period the birds in groups A, B, C and D were given experimental diets at the rate of 60 g/bird and were placed on lighting program of 14L:10D. During production phase, the birds of all groups were fed a balanced layer diet (ad libitum) and birds were placed again on lighting program of 16L:8D. The results showed that the birds fed diets A, B and C showed greater (p 0.05) in ovarian weights were found among minerals supplemented groups A, B and C. The non-molted birds (group E) exhibited the greatest (p<0.05) feed intake over the 2 weeks molt whereas birds on minerals supplemented diets ate the least (p<0.05) feed. On average non-molted hens fed a balanced layer diet and molted hens fed without minerals diet had lower (p<0.05) egg production when compared with molted hens fed mineral added diets after 20 weeks post molt. However, molted hens fed without minerals diet had significantly higher egg production than that of non-molted hens fed a balanced layer diet. Egg shell quality and Haugh unit score improved (p<0.05) in molted hens compared to non-molted hens. Based on the results of this study, mineral feeding appears to be the best alternative to without mineral feeding in molting methods and yield comparable results.
Dynamic Identification and Early Warning of Investment Inefficiency of Listed Companies in China--Based on the Perspective of Model Building and Upgrading

Investment is the driving force of economic growth, but inefficient investment behavior can be seen everywhere. How to identify the inefficient investment, and grasp the early warning technology for inefficient investment behavior is very practical significance. Based on the construction and upgrading of the two-tier stochastic frontier model to overcome the shortcomings of previous practices, we have carried on the thorough analysis to the Current topic, and has drawn the conclusion: (1) The result of model comparison before and after upgrade is that:Compared to the annual growth rate, using of Tobin‟s Q to measure the investment opportunities of the enterprise is more valuable. (2) The result of identifying inefficient investment behavior is that: From a macro perspective, the overall performance of Listed Companies in China is lack of investment; but on the micro level, the investment offset caused by investment game is not balanced in different years. (3) The result of early-warning inefficient investment behavior is that:When exogenous variables are introduced into the upgraded model , the newly synthesized model is able to recognize the interference intensity of game factors; At the present stage of China, the improvement of the corporate debt ratio is not a magic weapon to restrict the management's wanton investment.
Multiple myeloma in elderly patients: prognostic factors and outcome

Abstract: Objectives: Purpose of this study was to compare prognostic factors and outcome of patients with multiple myeloma (MM) aged >70 yr at diagnosis with those of younger patients. We also applied the recently proposed International Staging System (ISS) for MM in these patients. Patients and methods: Among 1,162 newly diagnosed, symptomatic MM patients included in our database, 357 (31%) were >70 yr of age. Clinical and laboratory variables were evaluated in patients >70 yr and in younger patients and were assessed for possible correlation with survival in patients >70 yr of age. Results: Most clinical and laboratory features were similar in the two groups of patients but older patients presented more frequently with advanced ISS (P = 0.02). Despite similar response rates to primary treatment, younger patients survived longer than patients >70 yr of age (40 vs. 28 months, P = 0.001). There was a longer survival of younger patients than that of older patients diagnosed with ISS stage 1 (median 71 vs. 54 months, P = 0.007) and ISS stage‐2 patients (median: 38 vs. 26 months, P = 0.0008) but for patients with ISS stage 3 median survival was similarly poor in the younger and older age group (21 and 20 months, P = 0.283). Other variables associated with impaired prognosis were severe anemia, extensive bone marrow plasmacytosis and elevated serum LDH. Conclusions: Older patients with MM present more often with advanced ISS and have significantly shorter survival than younger patients. The ISS retained its prognostic significance within the group of elderly patients.
Chemoprotective effect of diallyl trisulfide from garlic against carbon tetrachloride‐induced acute liver injury of rats

Diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS) are principal constituents of garlic oil. We studied the effect of these sulfides on the phase II drug‐metabolizing enzymes, and on the rat model of acute liver injury induced by carbon tetrachloride (CCl4). A highly purified form of each sulfide (more than 99% purity) was administered i.p. to rats at a concentration of 10 or 100 μmol/kg body weight for 14 consecutive days. DATS (10 μmol/kg) and DADS at a 10‐fold higher dose (100 μmol/kg) significantly increased the activities of glutathione S‐transferase (GST) and quinone reductase (QR); whereas DAS did not. In the CCl4‐induced acute liver injury model of rats, DATS (10 μmol/kg) significantly suppressed the increase in plasma lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) activities. In conclusion, hepatic phase II enzymes were induced strongly by the trisulfide and weakly by the disulfide, but not by DAS. DATS significantly reduced the liver injury caused by CCl4. DATS may be one of the important factors in garlic oil that protects our body against the injury caused by radical molecules.
Treatment of Pediatric Burkitt Lymphoma in Turkey

This study aimed to assess the demographic data and treatment results of children who were diagnosed with Burkitt lymphoma and treated according to the Berlin-Frankfurt-Münster-95 (BFM) protocol in a single institution. A total of 48 patients (37 boys, 77%) with a median age of 8 years (range 2 to 16 years) at diagnosis, were evaluated. Primary tumor sites were abdomen (70.8%), head and neck (22.9%), peripheral lymph node (2%), bone (2%), and testis (2%). The 5-year overall survival (OS) and event-free survival (EFS) were 78.1±4% and 76.6±6%, respectively. In univariate analysis, hemoglobin level less than 10 g/dL, cerebrospinal fluid (CSF) positivity and dialysis requirement at diagnosis were found to be important reverse predictor factors for EFS (P; 0.001, 0.001, 0.004, respectively). In multivariate analysis, hemoglobin level less than 10 g/dL and dialysis at diagnosis were found to be important reverse predictor factors for EFS (P; 0.0001). The EFS of our patients was lower than the values achieved with BFM-95 protocol in other centers. This study provides evidence that low hemoglobin level, CSF positivity and dialysis at diagnosis were important predictor factors for EFS in children with Burkitt lymphoma.
SARs in a three-year-old-child: Comparison between an anatomically realistic model and uniform and nonuniform scaling models

We compared the SARs of the anatomically realistic model of a three-year-old child exposed to vertically and horizontally polarized electromagnetic waves in the frequency range from 30 MHz to 3 GHz with those of the uniform and nonuniform scaling models. We found that it is important to use the anatomically realistic model for highly precise simulation for three-year-old children.
Regulation of tumor invasion and metastasis in protein kinase C epsilon‐transformed NIH3T3 fibroblasts

Protein kinase C epsilon is an oncogenic, actin nucleating protein that coordinately regulates changes in cell growth and shape. Cells constitutively expressing PKCϵ spontaneously acquire a polarized morphology and extend long cellular membrane protrusions. Here we report that the regulatory C1 domain of PKCϵ contains an actin binding site that is essential for the formation of elongate invadopodial‐like structures, increased pericellular metalloproteinase activity, in vitro invasion of a Matrigel barrier, and the invasion and metastasis of tumors grown in vivo by PKCϵ‐transformed NIH3T3 fibroblasts in nude mice. While removing this small actin binding motif caused a dramatic reversion of tumor invasion, the deletion mutant of PKCϵ remained oncogenic and tumorigenic in this experimental system. We propose that PKCϵ directly interacts with actin to stimulate polymerization and the extension of membrane protrusions that transformed NIH3T3 cells use in vivo to penetrate and degrade surrounding tissue boundaries. J. Cell. Biochem. 85: 785–797, 2002. © 2002 Wiley‐Liss, Inc.
Epitope Mapping of the Melanosomal Matrix Protein gp100 (PMEL17)

Melanosomes, specific organelles produced only by melanocytes, undergo a unique maturation process that involves their transition form amorphous rounded vesicles to fibrillar ellipsoid organelles, during which they move from the perinuclear to the distal areas of the cells. This depends upon the trafficking and processing of gp100 (also known as Pmel17 and the silver protein), a protein of great interest, because it elicits immune responses in melanoma patients but in which specific function(s) remains elusive. In this study, we have used biochemical and immunochemical approaches to more critically assess the synthesis, processing, glycosylation, and trafficking of gp100. We now report that gp100 is processed and sorted in a manner distinct from other melanosomal proteins (such as tyrosinase, Tyrp1 and Dct) and is predominantly delivered directly to immature melanosomes following its rapid processing in the endoplasmic reticulum and cis-Golgi. Following its arrival, gp100 is cleaved at the amino and at the carboxyl termini in a series of specific steps that result in the reorganization of immature melanosomes to the fibrillar mature melanosomes. Once this structural reorganization occurs, melanogenic enzymes begin to be targeted to the melanosomes, which are then competent to synthesize melanin pigment.
Severe eczema vaccinatum in a household contact of a smallpox vaccinee.

BACKGROUND We report the first confirmed case of eczema vaccinatum in the United States related to smallpox vaccination since routine vaccination was discontinued in 1972. A 28-month-old child with refractory atopic dermatitis developed eczema vaccinatum after exposure to his father, a member of the US military who had recently received smallpox vaccine. The father had a history of inactive eczema but reportedly reacted normally to the vaccine. The child's mother also developed contact vaccinia infection. METHODS Treatment of the child included vaccinia immune globulin administered intravenously, used for the first time in a pediatric patient; cidofovir, never previously used for human vaccinia infection; and ST-246, an investigational agent being studied for the treatment of orthopoxvirus infection. Serological response to vaccinia virus and viral DNA levels, correlated with clinical events, were utilized to monitor the course of disease and to guide therapy. Burn patient-type management was required, including skin grafts. RESULTS The child was discharged from the hospital after 48 days and has recovered with no apparent systemic sequelae or significant scarring. CONCLUSION This case illustrates the need for careful screening prior to administration of smallpox vaccine and awareness by clinicians of the ongoing vaccination program and the potential risk for severe adverse events related to vaccinia virus.
Contributions of Ambulatory Blood Pressure Monitoring in Prognostic Stratification of Hypertensive Patient

Although multiple and carefully performed clinical blood pressure measurements may indeed reach a diagnostic power similar to that 24 h, this rarely is performed in practice, due to the very short duration of the physician visit [5] . Only ABPM allows blood pressure variability over day/night to be detected, therebing providing a parameter that may have an independent prognostic value, and it is confirmed its value in variability determination [6-7] . Moreover, only ABPM may cast some light in symptomatic episodes that occur over 24 h, either because of blood pressure increases or of blood pressure reductions. This approach may be usefully employed not only in the diagnosis of hypertension, but also when evaluating the rate and the severity of hypotensive episodes [5] .
The scalability of 8T-SRAM cells under the influence of intrinsic parameter fluctuations

Intrinsic parameter fluctuations are already a limiting factor for 6-Transistor SRAM scaling. In order to maintain the benefits of CMOS scaling, new SRAM cell designs are necessary. An 8-Transistor SRAM cell structure is investigated and the impact of random doping fluctuations on its read and write noise margins, considering various supply voltages, are discussed. The results demonstrate impressive scalability, and indicate that the scaling window is still open for SRAM in the deca-nanometer regime.
Social and emotional development from a cultural perspective.

The study of social and emotional development is recognized for its complexity. To better understand developmental norms, and deviations thereof, researchers typically focus on individual (e.g., temperament), interactional (e.g., parenting behaviors), and relational (e.g., attachment, friendship) levels of analysis. Often forgotten, however, is the extent to which cultural beliefs and norms play a role in the interpretation of the acceptability of individual characteristics and the types and the ranges of interactions and relationships that are likely or permissible. This special issue comprises four sections in which culture is examined insofar as it relates to the aforementioned levels of social analysis: "Emotional Development," "Parenting and Parent-Child Relationships," "Social Cognition and Social Relationships," and "Social and Emotional Adjustment and Maladjustment. " Each section is followed by a commentary.
Molecular changes in the equine follicle in relation to variations in antral follicle count and anti-Müllerian hormone concentrations.

REASONS FOR PERFORMING STUDY The wide variation in circulating anti-Müllerian hormone (AMH) concentrations between mares is attributed to differences in antral follicle count (AFC) which may reflect follicular function. There are few data regarding variations in AFC and associated regulatory factors for AMH in the equine follicle during follicular development. OBJECTIVES To examine molecular and hormonal differences in the equine follicle in relation to variations in AFC and circulating AMH concentrations during follicular development and to identify genes co-expressed with AMH in the equine follicle. STUDY DESIGN Observational study. METHODS Plasma AMH concentrations and AFC were determined in 30 cyclic mares. Granulosa cells, theca cells and follicular fluid were recovered from growing (n = 17) or dominant follicles (n = 13). The expression of several genes, known to be involved in folliculogenesis and steroidogenesis, was examined using real-time reverse transcriptase polymerase chain reaction and immunohistochemistry. Intrafollicular oestradiol and AMH concentrations were determined by immunoassay. RESULTS Within growing follicles, the expression of AMH, AMHR2, ESR2 and INHA in granulosa cells was positively correlated with AFC and plasma AMH concentrations. In addition, the expression of ESR1 and FSHR was positively associated with plasma AMH concentrations. No significant associations were detected in dominant follicles. Furthermore, there was no association between AMH or oestradiol concentrations in follicular fluid and variations in AFC. Finally, the expression of AMH and genes co-expressed with AMH (AMHR2, ESR2 and FSHR) in granulosa cells as well as intrafollicular AMH concentrations decreased during follicular development while intrafollicular oestradiol concentrations increased and were inversely related to intrafollicular AMH concentrations. CONCLUSIONS This study indicates that variations in AFC and circulating AMH concentrations are associated with molecular changes in the growing equine follicle.
What does the actor need to perform in health care? Emotional demands, skills and competencies

This article aims to explore the required skills and competencies of the actor who works in health-care systems. A narrative inquiry gave the opportunity for participants to elaborate on their understandings of their direct or indirect engagement with theatre in hospitals. Data were collected in the form of ten narrative interviews with experienced actors in hospitals and drama trainees. Inductive thematic analysis of this collection of qualitative data was used to allow findings to emerge from frequent or significant themes inherent in the semi-structured interviews. The study demonstrates a defensible emphasis on key themes, including the predictable professional skills such as acting in participatory dramas, using theatre improvisation and puppetry, and interpersonal skills such as emotional intelligence and empathetic awareness.
Performance in the Presence of Risk

This paper proposes a managerial control tool that integrates risk in efficiency measures. Building on existing efficiency specifications, our proposal reflects the real banking technology and accurately models the relationship between desirable and undesirable outputs. Specifically, the undesirable output is defined as non-performing loans to capture credit risk, and is linked only to the relevant dimension of the output set. We empirically illustrate how our efficiency measure functions for managerial control purposes. The application considers a unique dataset of Costa Rican banks during 1998-2012. Results’ implications are mostly discussed at bank-level, and their interpretations are enhanced by using accounting ratios. We also show the usefulness of our tool for corporate governance by examining performance changes around executive turnover. Our findings confirm that appointing CEOs from outside the bank is associated with significantly higher performance ex post executive turnover, thus suggesting the potential benefits of new organisational practices.
Bone marrow metastases in children with solid tumors.

Of 213 children with various solid tumors, 493 bone marrow aspirates were examined. Malignant cells were found in bone marrows of 49 of 90 patients with neuroblastoma, 5 of 25 patients with rhabdomyosarcoma, 3 of 13 patients with retinoblastoma, 1 of 13 patients with miscellaneous sarcomas, and 2 of 5 patients with ganglioneuroblastoma. The PAS reaction was helpful in the recognition of rhabdomyosarcoma cells. Tumor cells in the marrows of four of five patients with rhabdomyosarcoma were PAS positive. Bone marrow examinations were useful in selecting an appropriate treatment program, in assessing prognosis, and in determining response to therapy.
Complex Network Characteristics and Invulnerability Simulating Analysis of Supply Chain

To study the characteristics of the complex supply chain, a invulnerability analysis method based on the complex network theory is proposed. The topological structure and dynamic characteristics of the complex supply chain network were analyzed. The fact was found that the network is with general characteristics of the complex network, and with the characteristics of small-world network and scale-free network. A simulation experiment was made on the invulnerability of the supply chain network in different attack modes, of which the outcome demonstrates that the supply chain network is not only with the robustness in random failure, but also with the vulnerability to deliberate assault. In addition, the outcome also shows the network reliability depends on the stability of critical nodes (i.e. core enterprises). As a result, it is vital to ensure this kind of enterprise operating normally and efficiently.
Crystal structure of 2-[9-(2-hydroxyphenyl)-1,8-dioxo-1,2,3,4,5,6,7,8,9,10-decahydroacridin-10-yl]acetic acid

The title compound, C21H21NO5, crystallizes with two molecules in the asymmetric unit. In each molecule, the central 1,4-dihydropyridine ring adopts a shallow sofa conformations (with the C atom bearing the phenol ring as the flap), whereas the pendant cyclohexene rings both have twisted-boat conformations. Each molecule features an intramolecular O—H⋯O hydrogen bond, which closes an S(8) ring. In the crystal, the molecules are linked by O—H⋯O, C—H⋯O and C—H⋯π interactions, forming a three-dimensional network.
Real-time 3D shape measurement system with full temporal resolution and spatial resolution

Numerous fast 3D shape measurement systems based on pattern projection method have been developed in the recent years, but measuring arbitrary dynamic 3D shape with full resolution, including temporal resolution and spatial resolution, is still a big challenging problem. This paper presents a real-time 3D measurement system with full spatial resolution and temporal resolution. In this system, three-step phase-shifting algorithm is employed for full spatial resolution measurement, and a multi-view phase-shifting correspondence is used to search the corresponding point independently without additional images. So any adjacent three phase-shifting images in the continuous capturing stream can be used to reconstruct arbitrary 3D shape, the 3D acquisition speed can be as fast as the camera capturing speed to achieve full temporal resolution. Moreover, for developing an accurate measurement system the calibration method is also presented, and it can obtain more accurate internal and external parameters than traditional method in presence of inaccuracy of calibration target. And a hybrid computing architecture based accelerate calculation method is introduced to achieve real-time 3D measurement, and the computation speed can be above 280 times faster than before. The experiments indicate that our system can perform 1024 × 768 full spatial resolution and 220 fps full temporal resolution 3D measurement, and it can also realize real-time 3D measurement at average speed of 50 fps.