Miracle-dz/UniFAR-FTUs huggingface dataset:
Sentiment Analysis as Reputational Risk Indicator

Fundaments of classification lie on the interdependences between the features and the labels to classify. For social parameters, this relationships are difficult to model and measure. In this paper, a way of obtaining a social indicator using sentiment analysis in Twitter is explained. With the classification of opinions as good or bad, it can be formed a metric for reputation. Naive Bayes classifier has been tested with a different construction of features, which lead us to a new classifier. The object to classify is not consider as a vector to features; instead, a union of them. This approximation avoid extreme scoring. The motivation for this work is to find a way to measure reputational risk for financial institutions, in order to give instruments for a more technological, motivated by RegTech paradigm, which links the regulation with the innovation of technology.
Sociodemographic Differences in Myocardial Infarction Risk Perceptions among People with Coronary Heart Disease

This study examines sociodemographic differences in myocardial infarction (MI) risk perceptions among people with coronary heart disease (CHD) (N = 3130). Two variables for comparative risk perceptions were computed: (1) own risk compared to that of an average person; and (2) own risk compared to that of an average person with CHD. Comparative optimism in MI risk perceptions was common, particularly among men and those with higher education. CHD severity and psychosocial resources mediated these sociodemographic differences. These results suggest challenges for secondary prevention in CHD, particularly regarding psychosocial interventions for communicating risk information and supporting lifestyle adjustments.
Coalition game for video content clustering in content delivery networks

Game theory is a powerful tool that has recently been used in networks to improve the end users' quality of experience (e.g. decreased response time, higher delivery rate). In this paper, we propose to use game theory in the context of Content Delivery Networks (CDNs) to organize video contents into clusters having similar request profiles. The popularity of each content in the cluster can be determined from the popularity of the representative of the cluster and used to store the most popular contents close to end users. A group of experts and a decision-maker predict the popularity of the representative of the cluster. This considerably reduces the number of experts used. More precisely, we model the clustering problem as a hedonic coalition formation game where each coalition represents a cluster. The coalition game converges to a stable partition representing a solution of the problem considered. We compare the results of this approach with the clustering obtained by the K-means algorithm. We evaluate the impact of the content profile observation window considered to establish the clustering. We also evaluate the complexity of the proposed algorithm. Simulation results are obtained on traces of a real CDN. Finally, we extend the proposed approach to model an on-line clustering reflecting the CDN dynamics in terms of proposed contents and contents solicitations.
Eureka: A gold rush play integrating the performing arts into elementary social studies curriculum

The purpose of this project is two-fold. The first purpose is to explore the benefits of incorporating the arts in the education of all students. Incorporating the arts into other curricular areas enhances learning and makes it more meaningful to the student. The second purpose is to develop a performance program that brings the California Gold Rush era and cultural diversity of that period of history alive. This program is designed to be adaptable to the user's particular school site, number of students and requires limited rehearsal time. This program format has been developed to encourage more teachers to incorporate the performing arts into other curricular areas, especially history; to bring the subject matter alive to the students. This first part of the project examines current research related to integrating the arts into education and the impact it has on enhancing the learning process. The performance program is developed to be adaptable to most school sites with complete participation of any class or grade level size. It includes steps on how to develop a California Gold Rush play based on student
Global Temperature, R&D Expenditure, and Growth

We shed new light on the macroeconomic effects of rising temperatures. In the data, a shock to global temperature dampens expenditures in research and development (R&D). We rationalize this empirical evidence within a stochastic endogenous growth model, featuring temperature risk and growth sustained through innovations. In line with the novel evidence in the data, temperature shocks undermine economic growth via a drop in R&D. Moreover, in our endogenous growth setting temperature risk generates non-negligible welfare costs (i.e., 11% of lifetime utility). An active government, which is committed to a zero fiscal deficit policy, can offset the welfare costs of global temperature risk by subsidizing the aggregate capital investment with one-fifth of total public spending.
Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases

Background and purpose: Glucocorticoids are highly effective in the therapy of inflammatory diseases. Their value, however, is limited by side effects. The discovery of the molecular mechanisms of the glucocorticoid receptor and the recognition that activation and repression of gene expression could be addressed separately opened the possibility of achieving improved safety profiles by the identification of ligands that predominantly induce repression. Here we report on ZK 245186, a novel, non‐steroidal, low‐molecular‐weight, glucocorticoid receptor‐selective agonist for the topical treatment of inflammatory dermatoses.
Effect of broiler breeders fed with corn or sorghum diet and canthaxanthin supplementation on production and reproductive performance

&NA; This study was designed to evaluate the effect of corn or sorghum diet and canthaxanthin (CX) supplementation on performance in broiler breeders. A total of 440 females with similar body weight (BW) (3.71 ± 0.14 kg) and 60 roosters were placed in an open‐sided house with 20 pens, randomly distributed in a factorial arrangement (2 × 2). There were 4 diets of 2 ingredients; corn (CO) or sorghum (SO) and 2 levels of CX; 6 mg/kg (CX) and 0 mg/kg (NCX) totaling 5 replicate pens of 22 females and 3 males each, from 42 to 65 wk, divided in 2 periods (from wk 42 to 53 and wk 54 to 65). Birds' BW was measured every 28 d and mortality rate was calculated at the end of trial. Egg production (%), egg specific gravity (g/cm3), egg weight (g), yolk weight (%), albumen weight (%), eggshell weight (%) and yolk colorimetric score were measured weekly. Incubation parameters were recorded in 12 incubations to evaluate hatching eggs, hatching (%), hatchability (%), fertility (%), weight of the chicks born and their quality. The BW, mortality, percentage of yolk and albumen weight, fertility and some incubation parameters were not affected (P > 0.05) by diets used. An increase in the egg production, hatching eggs, chicks born and first quality chick by hen at the second period were observed in CX breeder's diets (P = 0.0066; P = 0.0060; P = 0.0368; P = 0.0326). Egg specific gravity and eggshell weight were improved at the first period by SO+CX diet (P = 0.0138; P = 0.0209) and the same effect to egg weight, but at the second period (P = 0.0251). The CX was well absorbed from the diet and effectively transferred to the egg yolk, thereby increasing egg yolk pigmentation in the both periods (P < 0.0001). The CX supplementation in broiler breeder diets improved the productive and reproductive performance (laying% and hatchable eggs) at the second period, also to the both periods improved the egg yolk pigmentation.
Phosphor-Free GaN-Based Transverse Junction White-Light Light-Emitting Diodes With Regrown n-Type Regions

In this study, we demonstrate a GaN-based phosphor-free white-light light-emitting diode (LED), which is composed of GaN-based dual-wavelength (blue and yellow-green) multiple-quantum-wells (MQWs) and a transverse p-n junction. The device was realized by the regrowth of n-type GaN layers on the sidewall of p-type GaN and undoped MQWs. The problems related to the bias-dependent shape of the electroluminescence spectra that occur in traditional phosphor-free white-light LEDs (with vertical p-n junctions) are greatly minimized. The current-voltage performance of our device is comparable to that of the commercially available phosphor white-light LEDs. In addition, the dynamic measurement results indicate that we can attain a much higher modulation bandwidth (22 versus 3 MHz) with this device than with the currently available commercial ones.
Organisational Narcissism: A Review of the Indicators in the Major Australian Banks

Purpose: The purpose of this paper is to explore indicators of organisational narcissism in the four major Australian banks. With investigation encompassing the CEO letters to shareholders and the vision/mission statements of the respective banks. The paper develops an alternative model for considering influences which impact on corporate culture and culminate in the evolution of organisational narcissism. Design/method/approach: The approach used in this paper involves the application of a form of content analysis focusing on the CEO letters to shareholders and the vision/mission statements of the respective banks. Findings: The existence of a narcissistic organization is a product of the capitalist society with its focus on the need to succeed against all competition. The subsequent organizational culture inevitably becomes narcissistic and in turn the employees at all levels are subject to indoctrination. Originality/value: The findings from this study addresses a gap in the literature and provides for future comparative studies be conducted on the engagement of students with social networking sites to better understand internet addiction. ;
Expression of the erythropoietin gene

Injection of cobalt into rats resulted in erythropoietin (EPO) mRNA accumulation in the kidney. The same response was obtained upon bleeding. No EPO mRNA was detected in the spleen, salivary gland, or thymus following cobalt injection or bleeding. In some animals, but not in others, EPO mRNA was also expressed in the liver in response to cobalt injection. Time course studies showed that message appearance begins sometime between 3 and 6 h after cobalt injection. This correlated very well with the EPO concentration in the circulation; EPO levels in the circulation were the same as those of controls at 3 h but increased to six- to sevenfold that of controls by 6 h after cobalt injection. The mature EPO mRNA in the rat and mouse comigrated with the 18S rRNA, indicating that it is about 1,850 nucleotides in length.
Organic Carbon Concentrations in High- and Low-Productivity Areas of the Sulu Sea

The sequestration of anthropogenic carbon dioxide in the form of organic carbon and its eventual deposition in the sediments is an important component of the marine carbon cycle. In the Sulu Sea, Philippines, organic carbon contents in the sediments have been relatively well studied, but the processes that describe the organic carbon distributions in the water column have not been elucidated. Dissolved and particulate organic carbon (DOC, POC) concentrations were measured at several stations in the Sulu Sea during the northeast monsoon of 2007/2008 to understand the dynamics of organic carbon in this unique internal sea. Analyses of primary productivity estimates, beam attenuation coefficient (at 660 nm) profiles, and correlation coefficients among DOC, POC and other parameters (e.g., apparent oxygen utilization) at different layers of the water column indicate that surface primary productivity, upwelling, bottom intensified flows across sills, and ventilation from shallow sills, which may contain semi-labile DOC that is estimated to largely contribute to microbial respiration in the bathypelagic layer, are the major processes that affect the DOC and POC distributions in the Sulu Sea. The variability of these processes should be taken into consideration when assessing the sustainability of internal and marginal seas as carbon sinks.
Isolation and characterization of Gibberella intermedia CA3‐1, a novel and versatile nitrilase‐producing fungus

Nitrilase‐mediated biocatalysis has attracted substantial attention for its application in carboxylic acid production in recent years. In the present study, the fungus CA3‐1 was isolated and identified as Gibberella intermedia based on its morphology, its 18S ribosomal DNA (rDNA), and internal transcribed spacer (ITS) sequences. The enzymatic properties of G. intermedia resting cells were determined, and the optimum activity was achieved at 40 °C with pH 7.6. The half‐lives of the nitrilase at 30, 40, and 50 °C were 231.1, 72.9, and 6.4 h, respectively. This Gibberella nitrilase showed a wide substrate spectrum with high specificity for heterocyclic and aliphatic nitriles. It remained extremely active in 5% propanol. The presence of Ag+, Hg2+, and excess substrate inhibited the nitrilase activity, whereas Fe2+, Mn2+, and Li+ improved enzyme activity. 3‐Cyanopyridine (50 mM) was hydrolyzed into nicotinic acid within 30 min, whereas only <5% of nicotinamide was detected. The results show that this fungal nitrilase is a promising candidate for commercial application in nicotinic acid production.
Effects of SMAD7 Overexpression on Peritoneal Inflammation in a Rat Peritoneal Dialysis Model

Objective Transforming growth factor-beta (TGF-β) has been shown to play a role in peritoneal complications due to long-term peritoneal dialysis (PD). In this study, we examined the effects of the TGF-β signaling pathway on peritoneal inflammation associated with PD in rats by over-expressing Smad7, an inhibitor of TGF-β/Smad signaling. Methods Peritoneal inflammation was induced in male Sprague-Dawley rats by intraperitoneal injections of 4.25% glucose dialysate (100 mg/kg body weight) daily for 4 weeks, with the addition of lipopolysaccharides (0.6 mg/kg body weight) on days 8, 10, 12, 22, 24, and 26. Peritoneal Smad7 gene transfer was achieved using an ultrasound microbubble mediated, doxycycline regulated, Smad7-expressing plasmid on day 0 and day 14 after initiation of PD. An empty vector was used as control. All rats were sacrificed after 4 weeks of PD. Peritoneal inflammatory response, including infiltration of total leukocytes (OX-1 positive) and macrophages (ED-1 positive) and expression of interleukin (IL)-1β) and tumor necrosis factor-alpha (TNF-α), was examined by immunofluorescence and RT-PCR. Results After PD, peritoneal inflammation developed in control animals, as demonstrated by an increase in the number of OX-1-positive and ED-1-positive cells and upregulation of IL-1β and TNF-α mRNA and protein expression. In contrast, in animals treated with Smad7 gene transfer, IL-1β and TNF-α expression and OX-1-positive and ED-1-positive cell infiltration were significantly inhibited. Furthermore, prevention of peritoneal inflammation by overexpression of Smad7 was associated with inhibition of phosphorylation of Smad2/3, a downstream of the TGF-β signaling pathway, as well as TGF-β1 expression. Conclusion Overexpression of Smad7 suppresses peritoneal inflammation induced by high glucose and lipopolysaccharides. The ability of Smad7 gene transfer to inhibit peritoneal inflammation indicates that targeting TGF-β/Smad signaling may represent a new therapeutic strategy for the treatment of peritoneal complications associated with PD.
Antitubercular activity of novel substituted 4, 5-dihydro-1H-1-pyrazolylmethanethiones

A series of, anilino-5- (substituted) phenyl -3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolylmethanethione and 2-chloroanilino-5- (substituted) phenyl -3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolylmethanethione were synthesized by the reaction between hydrazine hydrate and the chalcones (3a–k) followed by condensation with the appropriate aryl isothiocyanate which yielded the N-substituted pyrazoline derivatives. These were tested for their in-vitro anti-mycobacterial activity against INH resistant Mycobacterium tuberculosis (INHR MTB) using the BACTEC 460 radiometric system. Compound 2-chloroanilino-5-(2,6-dichlorophenyl)-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolylmethanethione (6i) was found to be most active agent with a minimum inhibitory concentration of 0. 96μg/mL.
Selection on seedling emergence timing and size in an annual plant, Helianthus annuus (common sunflower, Asteraceae).

PREMISE Variation in seedling emergence timing is considered adaptive over the long term in wild populations, but early emergence can result in a fitness advantage. To explore the adaptive significance of seedling emergence timing, it should be studied under realistic conditions and in the context of other traits that influence fitness. METHODS In a common garden, we monitored maternal families from seed to flowering (including over winter) with intra- and interspecific competition. We assessed the effects of emergence timing and plant size on survival to anthesis in different genetic backgrounds and under varying competition. KEY RESULTS We found genetic variation for emergence (probability and timing), size, and survival to anthesis. We also found negative selection, both phenotypic and genetic, on emergence time, such that early emergers (day 8) had almost twice as great a predicted probability of surviving as later emergers (day 28). Size had strong positive effects on survival and, furthermore, the beneficial effects of early emergence may be mediated through size. Maternal family and competitive environment can also affect selection on emergence timing. CONCLUSIONS Our results indicate that early emergence is related to greater survival in wild sunflower, although there may be little direct selection on this trait; rather, its importance may be mediated by its effects on highly adaptive traits associated with size. Also, the effects of early emergence may vary across genetic backgrounds and competitive conditions, facilitating the maintenance of variation for this trait across a diverse landscape.
Defining a Caring Hospital by Using Currently Implemented Survey Tools

Health care organizations are constantly striving to provide a more cost-effective and higher quality treatment within a caring environment. However, balancing the demands of regulatory agencies with the holistic needs of the patient is challenging. Further challenging is how to define those hospitals that provide an exceptional caring environment for their patients. By using survey tools that are already being administered in hospital settings, the opportunity exists to analyze the results obtained from these tools to define a hospital as a caring organization without the added burden of separate data collection.
Reafferent or Redundant: Integration of Phonotaxis and Optomotor Behavior in Crickets and Robots

A general problem in understanding the mechanisms underlying animal behavior is the integration or interaction of different sensorimotor systems. Webb and Harrison (2000a, b) investigated the addition of an optomotor reflex to a sound-localizing robot modeled on cricket behavior. Böhm, Schildberger, and Huber (1991) proposed a simple additive mechanism to explain how the cricket combines the two behaviors. Problems implementing this on the robot led us to propose an alternative inhibition mechanism, which proved effective. Here we directly compare these two possibilities and several further alternatives. First, in a simulation of the open-loop paradigm used by Böhm et al. we demonstrate that there are at least five algorithms (including “efferent copy”) that may adequately account for the data they present. We then consider possible neural implementations of several of these schemes, and test them in robot experiments. The results suggest that inhibition is both neurally plausible and effective as a means of combining these behaviors in real sensorimotor situations.
Expanding the genetic code of Saccharomyces cerevisiae with methionine analogues

We replaced the single N‐terminal methionine in heterologously expressed human Cu/Zn superoxide dismutase with the non‐canonical methionine analogues homopropargylglycine and norleucine in the yeast Saccharomyces cerevisiae. Our non‐canonical amino acid incorporation protocol involves a two‐step procedure. In the first step, the methionine auxotrophic yeast cells are accumulated in synthetic medium containing methionine while the target protein production is shut off. After a short methionine depletion phase, the cells are transferred to inducing medium that contains the methionine analogue instead of methionine and target protein expression is switched on. The initially low level incorporation of ∼12% could be elevated to 40% by increasing the non‐canonical amino acid concentration in the medium by 10‐fold. With this approach we were able to produce up to 5 mg substituted protein per litre of yeast culture. Copyright © 2008 John Wiley & Sons, Ltd.
Outcome and treatment of elderly patients with ANCA-associated vasculitis.

BACKGROUND AND OBJECTIVES ANCA-associated vasculitis is commonly found in elderly patients, but there are few data concerning outcome and treatment in the highest age groups. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Consecutive patients (N=151) presenting between 1997 and 2009 were retrospectively included from local registries in six centers in Sweden, the United Kingdom, and the Czech Republic if diagnosed with microscopic polyangiitis or granulomatosis with polyangiitis at age ≥75 years during the study period. Patients were followed until 2 years from diagnosis or death. Data on survival and renal function were analyzed with respect to age, sex, ANCA specificity, renal function, C-reactive protein, comorbidities, and Birmingham Vasculitis Activity Score at diagnosis as well as treatment during the first month. RESULTS Median follow-up was 730 days (interquartile range, 244-730). Overall 1-year survival was 71.5% and 2-year survival was 64.6%. Older age, higher creatinine, and lower Birmingham Vasculitis Activity Score were associated with higher mortality in multivariable analysis. Patients who were not treated with standard immunosuppressive therapy had significantly worse survival. Renal survival was 74.8% at 1 year. No new cases of ESRD occurred during the second year. High creatinine at diagnosis was the only significant predictor of renal survival in multivariable analysis. CONCLUSIONS ANCA-associated vasculitis is a disease with substantial mortality and morbidity among elderly patients. This study showed a better prognosis for those who received immunosuppressive treatment and those who were diagnosed before having developed advanced renal insufficiency.
Applying the Byzantine Agreement in Wireless Sensor Networks based on clustering

Due to large communication overhead, applying Byzantine Agreement (BA) methods in Wireless Sensor Networks (WSNs) degrades their lifetime dramatically. Most of traditional proposed BAs assume that the processors are connected to unlimited resources of energy and the ideal links exist between them. A rough estimation about the required number of exchanged messages for decision in a network with n nodes is O(n2). Therefore, inefficient energy consumption becomes more challenging as network grows. Without any further actions, applying a BA method on a typical WSN is infeasible. In this paper, we propose a method for large scale WSNs which reaches agreement through two levels. In this method, we reduce the energy consumption of network through dividing the whole network to small groups of nodes by appropriate heuristic Leader First (LF) clustering; leading to fewer number of communications in shorter ranges. Our proposed method prolongs network lifetime, as well as maintaining reliability and robustness in a favorable range.