Miracle-dz/UniFAR-FTUs huggingface dataset:
A Prototype for IoT based Car Parking Management system for Smart cities

Background: Present day's car parking has become a major issue in urban areas with lack of parking facilities and increased amount of vehicles, due to this drivers who are searching for parking space they were roaming around the city in peak hours. This causes traffic, waste of time and money. Methods: To solve those problems, this prototype is developed using sensor circuit, RFID and IoT. RFID used here to detect the car details, IR sensor is used to find the presence of the car and all details are accessed from remotely through IoT. Findings: This system helps user to find parking space availability with the help of Internet of Things (IoT) technology by providing parking free space information. The IoT maintains the database of the parked vehicles through a shared server. So drivers can book the slots in advance and the parking information updated in server. In addition to the parking, theft management will be done i.e. a theft vehicle came for parking then the number plate is checked with theft list in the database, if it is in theft list then a message is sent to the police. Applications/ Improvements: This prototype developed for the parking system with less human interaction, increases flexibility and security. This system is employable in airports and multiplexes parking.
A filtering concept for improving the angle-based forwarding scheme in Vehicular Ad-Hoc Network communications

Vehicular Ad-hoc Network (VANET) communications are mobile communication alternatives allowing vehicles to exchange information among them with a suitable forwarding scheme. The forwarding scheme is a mechanism to select proper candidate nodes as the intermediate node. Current angle-based forwarding schemes take into account a Horizontal Relative Angle (HRA) and propose Vertical Relative Angle (VRA) as an alternative. The introduction of a filtering concept, implementing both HRA and VRA, restricts the number of insignificant candidates. Under various VANET communication factors (e.g., network density, mobility, and road level topology) the work presented here investigates the VRA scheme to improve the forwarding decision especially in the three-dimensional case within a large city environment.
N-(4-Bromophenyl)-3,5-dinitrobenzamide

The title molecule, C13H8BrN3O5, is slightly twisted, with the dihedral angle between the two benzene rings being 5.9 (1)°. In the crystal, N—H⋯O hydrogen bonds link the molecules into one-dimensional chains running along [101]. Further stabilization of the crystal structure is provided by π–π interactions [shortest centroid–centroid distance = 3.6467 (17) Å].
Digitoxin activates EGR1 and synergizes with paclitaxel on human breast cancer cells

Background: Numerous studies have suggested that digitalis derivatives promise to be superior to existing adjuvant therapy for breast cancer as to effects and side-effects. In the present study, we have used gene expression analysis to determine the molecular action of digitoxin on breast cancer cells and assessed digitoxin’s ability to synergize with the chemotherapy agent paclitaxel with respect to inhibition of cell proliferation Materials and Methods: We treated (Her2 overexpressing, ER low) MDA-MB-453 human breast cancer cells with digitoxin at four doses {20 ng/ml (26 nM) to 1 μg/ml} and collected RNA at 6 h and 24 h for gene expression analysis. To examine the effects on ER positive cells, we treated MCF7 cells with digitoxin at 1 μg/ml and collected RNA for RT-PCR analysis. In addition, we assayed the growth inhibitory effect of low doses of digitoxin combined with paclitaxel and determined combination index values. Results: To reveal primary effects, we examined digitoxin’s effect 6 h post-treatment with the highest dose, 1μg/ml, and found upregulation of the stress response genes EGR-1 and NAB2, lipid biosynthetic genes and the tumor suppressor gene p21, and downregulation of the mitotic cell cycle gene CDC16 and the replication gene PolR3B. RT-PCR analysis validated effects on stress response, apoptotic and cell cycle genes on MDA-MB-453 and MCF7 cells. Western blot analysis confirmed induction of EGR1 protein at 1 h and ATF3 at 24 h. Paclitaxel, as well as digitoxin, inhibited the in vitro activity of the purified Na+-K+-ATPase; digitoxin enhanced the growth inhibitory effects of paclitaxel on Her2 overexpressing breast cancer cells. Conclusions: Our studies show the potential of digitoxin to prevent and treat breast cancer and indicate that the combination of digitoxin and paclitaxel is a promising treatment for ER negative breast cancer. These findings are the first to alert physicians to the possible dangers to patients who take a combination of digitoxin and paclitaxel. The potential dangers ensuing when paclitaxel and digitoxin are combined are dependent on the dose of digitoxin.
Gene Dose Influences Cellular and Calcium Channel Dysregulation in Heterozygous and Homozygous T4826I-RYR1 Malignant Hyperthermia-susceptible Muscle*

Background: Muscle from heterozygous and homozygous T4826I-RYR1 MH-susceptible mice is investigated for biochemical and cellular abnormalities. Results: T4826I-RYR1 gene dose determines severity of [Ca2+]rest, mitochondrial, EC coupling, and Ca2+ channel impairments. Conclusion: T4826I-RYR1 channel dysfunction is regulated in vivo but imparts susceptibility to environmental triggers. Significance: T4826I-RYR1 is sufficient to confer MHS strongly dependent on gene dose. Malignant hyperthermia susceptibility (MHS) is primarily conferred by mutations within ryanodine receptor type 1 (RYR1). Here we address how the MHS mutation T4826I within the S4-S5 linker influences excitation-contraction coupling and resting myoplasmic Ca2+ concentration ([Ca2+]rest) in flexor digitorum brevis (FDB) and vastus lateralis prepared from heterozygous (Het) and homozygous (Hom) T4826I-RYR1 knock-in mice (Yuen, B. T., Boncompagni, S., Feng, W., Yang, T., Lopez, J. R., Matthaei, K. I., Goth, S. R., Protasi, F., Franzini-Armstrong, C., Allen, P. D., and Pessah, I. N. (2011) FASEB J. doi:22131268). FDB responses to electrical stimuli and acute halothane (0.1%, v/v) exposure showed a rank order of Hom ≫ Het ≫ WT. Release of Ca2+ from the sarcoplasmic reticulum and Ca2+ entry contributed to halothane-triggered increases in [Ca2+]rest in Hom FDBs and elicited pronounced Ca2+ oscillations in ∼30% of FDBs tested. Genotype contributed significantly elevated [Ca2+]rest (Hom > Het > WT) measured in vivo using ion-selective microelectrodes. Het and Hom oxygen consumption rates measured in intact myotubes using the Seahorse Bioscience (Billerica, MA) flux analyzer and mitochondrial content measured with MitoTracker were lower than WT, whereas total cellular calpain activity was higher than WT. Muscle membranes did not differ in RYR1 expression nor in Ser2844 phosphorylation among the genotypes. Single channel analysis showed highly divergent gating behavior with Hom and WT favoring open and closed states, respectively, whereas Het exhibited heterogeneous gating behaviors. [3H]Ryanodine binding analysis revealed a gene dose influence on binding density and regulation by Ca2+, Mg2+, and temperature. Pronounced abnormalities inherent in T4826I-RYR1 channels confer MHS and promote basal disturbances of excitation-contraction coupling, [Ca2+]rest, and oxygen consumption rates. Considering that both Het and Hom T4826I-RYR1 mice are viable, the remarkable isolated single channel dysfunction mediated through this mutation in S4-S5 cytoplasmic linker must be highly regulated in vivo.
Is Cash-Return Relation Risk Induced?

Palazzo [2012] finds a positive relation between cash holdings and stock return and attributes this to the association between cash and systematic risk with respect to growth options. In this paper, I try to test whether the relation between cash and return is driven by systematic risk that captured by cash. The empirical results do not support the risk explanation of cash-return relation. First, the loadings on CASH factor cannot predict returns, which is not consistent with rational frictionless asset pricing models. Second, CASH factor cannot reflect future GDP growth. Third, CASH and its factor loadings exhibit no association with implied cost of capital derived from analysts’ earnings forecasts. Overall, this paper casts doubt on the argument that cash can serve as a proxy of systematic risk in the explanation of cross sectional variation in stock returns.
Adoption of national electronic prescribing services in primary care in Europe - policy lessons for Ireland

______________________________________________________________ ii Declaration ____________________________________________________________ iii Acknowledgements _____________________________________________________ iv List of Appendices _____________________________________________________ viii List of Tables __________________________________________________________ ix List of Figures __________________________________________________________ x List of Abbreviations ___________________________________________________ xi Glossary of Terms and Abbreviations ____________________________________ xiii PART ONE: Introduction to ePrescribing ___________________________________ 1
Mechanism of the Mitogenic Effect of Fluoride on Osteoblast‐like Cells: Evidences for a G Protein–Dependent Tyrosine Phosphorylation Process

Recent results indicate that a fluoroalumino complex (AlFx) is probably the molecule responsible for the mitogenic effect of fluoride in MC3T3‐E1 osteoblast‐like cells. Initial analysis suggested that a tyrosine phosphorylation (tyr phos) process similar to that induced by thrombin and activation of the p42 MAP kinase (ERK 2) mediate this cellular response. In the present study, the signaling mechanism activated by AlFx was further investigated. The results indicated that AlFx dose‐dependently enhanced the tyr phos of the cell adhesion proteins FAK and paxillin, as well as of the adaptor molecules p46shc, p52shc, and p66shc and their association with GRB2. Pretreatment of MC3T3‐E1 cells with cytochalasin D completely prevented FAK and paxillin tyr phos without any alteration in the tyr phos of Shc proteins and activation of ERK2 induced by AlFx. This observation suggests that in confluent MC3T3‐E1 cells, there is no link between the activation of FAK induced by AlFx and the stimulation of ERK2. Pretreatment of the cells with pertussis toxin inhibited Shc phosphorylation, activation of ERK2, and markedly reduced cell replication induced by AlFx. This toxin also significantly reduced the stimulation of Pi transport activity induced by AlFx in these cells. Alteration in tyr phos induced by AlFx was not associated with any detectable inhibition of tyrosine phosphatase activity in MC3T3‐E1 cell homogenates, suggesting that enhanced tyr phos induced by AlFx probably resulted from activation of a tyrosine kinase. In conclusion, the results of this study suggest that the mitogenic effect of fluoride in MC3T3‐E1 osteoblast‐like cells is mediated by the activation of a pertussis toxin–sensitive Gi/o protein and suggest an important role for these heterotrimeric G proteins in controlling the growth and differentiation of bone‐forming cells.
New approach for transformation-invariant image and video watermarking in the spatial domain: self-spanning patterns (SSP)

A variety of robust non-perceptual watermarking methods have been proposed to solve the illegal copying and proof of ownership problems. Although a number of broad claims have been made in the field of robustness of various digital watermarking methods. It is still difficult to handle combined or non-linear geometric transformations. In this paper we propose the SSP approach. We use a correlation based watermark pattern approach in the spatial domain which operates on image inherent properties when selecting the marking positions: self spanning patterns (SSP). Each watermark pattern which represents one information bit of the whole watermark string is spanned over four image inherent properties like image edges or corners. These four points specify a polygon over which the watermark pattern is spanned using a polygon filling algorithm. After transformations we search for our points based on the image characteristics. Then we span our pattern over the points and check if there was a one or a zero embedded. Continuing that for all pattern positions we can build the whole watermark string. The advantage of the SSPs is that transformations need not be recognized, the marking positions and our pattern shape can be automatically found.
The Anaplasma phagocytophilum PleC Histidine Kinase and PleD Diguanylate Cyclase Two-Component System and Role of Cyclic Di-GMP in Host Cell Infection

ABSTRACT Anaplasma phagocytophilum, the etiologic agent of human granulocytic anaplasmosis (HGA), has genes predicted to encode three sensor kinases, one of which is annotated PleC, and three response regulators, one of which is PleD. Prior to this study, the roles of PleC and PleD in the obligatory intracellular parasitism of A. phagocytophilum and their biochemical activities were unknown. The present study illustrates the relevance of these factors by demonstrating that both pleC and pleD were expressed in an HGA patient. During A. phagocytophilum development in human promyelocytic HL-60 cells, PleC and PleD were synchronously upregulated at the exponential growth stage and downregulated prior to extracellular release. A recombinant PleC kinase domain (rPleCHKD) has histidine kinase activity; no activity was observed when the conserved site of phosphorylation was replaced with alanine. A recombinant PleD (rPleD) has autokinase activity using phosphorylated rPleCHKD as the phosphoryl donor but not with two other recombinant histidine kinases. rPleCHKD could not serve as the phosphoryl donor for a mutant rPleD (with a conserved aspartic acid, the site of phosphorylation, replaced by alanine) or two other A. phagocytophilum recombinant response regulators. rPleD had diguanylate cyclase activity to generate cyclic (c) di-GMP from GTP in vitro. UV cross-linking of A. phagocytophilum lysate with c-di-[32P]GMP detected an ∼47-kDa endogenous protein, presumably c-di-GMP downstream receptor. A new hydrophobic c-di-GMP derivative, 2′-O-di(tert-butyldimethylsilyl)-c-di-GMP, inhibited A. phagocytophilum infection in HL-60 cells. Our results suggest that the two-component PleC-PleD system is a diguanylate cyclase and that a c-di-GMP-receptor complex regulates A. phagocytophilum intracellular infection.
Abnormal liver enzymes in Thai patients with metabolic syndromes.

OBJECTIVE Elevated transaminases have been found to be associated with metabolic syndrome (MS) in many populations but little is known in Asians. The present study aimed to investigate the association between elevated hepatic enzymes in Thai patients diagnosed with MS. MATERIAL AND METHOD A cross-sectional study on 2,585 Thais was conducted. Blood pressure, waist circumference, fasting plasma glucose, triglyceride, HDL-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were measured. MS was diagnosed using NCEP/ATP III criteria with modified waist circumference for Asian. The association between MS with elevated liver enzymes was performed using logistic regression. RESULTS Twenty-seven percent of the subjects were found to have MS. The MS group had significantly higher mean AST, ALT, and ALP levels than the non-MS group (mean (SD) for AST 29.86 (18.97), 24.08 (12.71); ALT 38.39 (29.14), 24.38 (18.57); and ALP 73.45 (27.09), 65.72 (21.27) for MS and non-MS, respectively, p < 0.05). MS was significantly associated with elevated liver enzymes. The adjusted odds ratios (OR) were 2.2 (95% confidence interval (CI): 1.6-2.9), 2.3 (95% CI: 1.8-3.0), and 2.2 (95% CI: 1.1-4.2) for elevated AST, ALT, and ALP, respectively. ALT/AST ratio of > or = 1 was significantly associated with MS in both genders (adjusted ORs: 1.72 (95% CI: 1.28-2.32) for men and 2.30 (95% CI: 1.68-3.16) for women). CONCLUSION There is a strong association between metabolic syndrome and elevated liver enzymes. Further study is needed to investigate the long-term sequelae of liver abnormalities in those with metabolic syndrome in Thai population.
A decision making approach to relevance feedback in information retrieval: A model based on soft consensus dynamics

Information retrieval (IR) can be regarded as a natural instance of multicriteria decision making (MCDM). Queries are formulated as selection criteria aggregated by means of appropriate operators. Retrieval is then performed as a MCDM process by evaluating the degrees of satisfaction of the criteria by each document, and then aggregating them. Another decisional instance in IR concerns the problem of improving retrieval performance by taking into account user indications on documents relevance. Relevance feedback mechanisms exploit user‐system interaction in order to improve retrieval results by means of an iterative process of query refinement. In this process the main decisional issue is that of finding new concepts (terms) with which to expand–modify the initial query so that it better reflects the user's information needs. In this paper we introduce a relevance feedback mechanism based on a dynamical consensus model originally proposed in the framework of group decision making. In the relevance feedback context the consensual interaction highlights associations among the most significant terms in the relevant retrieved documents selected by the user. The resulting associative structure can then be used to expand the original query by including new terms which result strongly associated with those in the query. ©1999 John Wiley & Sons, Inc.
X-ray grating interferometry with a liquid-metal-jet source

A liquid-metal-jet X-ray tube is used in an X-ray phase-contrast microscope based on a Talbot type grating interferometer. With a focal spot size in the range of a few microns and a photon flux of ∼1012 photons/s×sr, the brightness of such a source is approximately one order of magnitude higher than for a conventional microfocus source. For comparison, a standard microfocus source was used with the same grating interferometer, showing significantly increased visibility for the liquid-metal-jet arrangement. Together with the increased flux, this results in improved signal-to-noise ratio.
Familial resemblance of schizotypic traits

Synopsis The goal of this study was to examine the familial resemblance of schizotypic traits, and to explore whether different schizotypic traits are familially related to one another. Several of the Chapmans' psychosis proneness scales were administered to a group of college students and their families. Evidence of at least some familial resemblance was found for both physical anhedonia and perceptual aberration, though it was stronger for anhedonia. Anhedonia and perceptual aberration appeared to be familially influenced independently of one another. Finally, the results indicated that offspring resembled their mothers more than they resembled their fathers on both anhedonia and perceptual aberration.
Information Provision and Preferences for Education Spending: Evidence from Representative Survey Experiments in Three Countries

Increasing tax revenues by reducing the shadow economy has been a central goal of tax policy and administration in the Republic of Korea since the National Tax Service was established as an independent agency in 1966. This paper examines the Tax Incentive for Electronically Traceable Payments, which was introduced by the Korean tax authorities in 1999 to promote payments made using credit cards, debit cards, and electronic cash receipts in business-to-consumer transactions. The tax incentive allows wage and salary earners to claim tax deductions for eligible purchases made using electronically traceable payments when they file their year-end income tax settlements. The tax incentive scheme greatly contributed to changing the Korean economy into a cashless economy over the past decade and a half. Card payments as a ratio of Korea's gross domestic product have ranked the highest in the world since 2005, reaching 49 percent in 2014. The Tax Incentive for Electronically Traceable Payments scheme has changed the taxpayer ratio over business income earners from stagnant at around 30 percent through the late 1990s, to approximately 80 percent at present. The effective personal income tax rate for business income followed a continuous upward trend, from 3.4 percent in 1998 to 6.3 percent in 2013. The total revenue increase driven by the tax incentive scheme was estimated as W 3.4 trillion, with the scheme's costs reaching W 1.9 trillion. The net gain was an estimated W 1.4 trillion (approximately US$1.3 billion), which increased personal income tax revenue by 4.2 percent. The tax incentive scheme also had a positive impact on income redistribution, decreasing the Gini coefficient by 0.11 percentage points.
Do Short Sellers Exacerbate or Mitigate Managerial Myopia? Evidence from Patenting Activities

We examine whether short sellers exacerbate or mitigate managerial myopia by using a firm’s patenting activities to capture managers’ myopic behavior. To establish causality, we use exogenous variation in short-selling costs generated by a quasi-natural experiment, Regulation SHO, which removes the tick restriction on a randomly-chosen subsample of Russell 3000 firms. We find that the quality, value, and originality of patents generated by treatment firms improve significantly more than control firms surrounding Regulation SHO, suggesting that short sellers are able to mitigate managerial myopia in investment decisions. The exposure to patenting-related litigation initiated by short sellers is a plausible mechanism through which short sellers curb myopic behavior, and managers of more opaque firms voluntarily disclose more information about their innovation activities in response to such litigation risk. Our paper provides new insights into a surprising and unintended real effect of short sellers – their mitigation of managerial myopia.
THE ROLE OF KNOWLEDGE MANAGEMENT ENABLERS IN SUCCESSFUL PROJECTS: CASE OF CONSTRUCTION INDUSTRY IN KENYA.

Construction companies which are highly project based, have always relied on their knowledge assets to provide services to clients. Recently, the term ‘knowledge management’ has been introduced; to promote greater collaboration through exchange of vital information among project teams, assist in necessary knowledge retention within organization, and to facilitate capturing and using of lessons learned from previous projects, so as to ensure greater project success. Hence, the research study intended to investigate the influence of integrating KM on the success of projects in the construction industry in Kenya, and a descriptive design was used to study the research objectives. Questionnaires were administered to about 65 professionals who were randomly selected from 28 Structural engineering firms, derived from a body; Association of Consulting Engineers of Kenya. Subsequently, descriptive statistics and inferential statistics were used to analyze the data before reporting and making recommendations. The study finally found out that KM is indeed in existence in most of the construction firms even though it was not fully grown. It was established that the KM enablers that are comprised of; organizational culture, structure, members of project and IT, have proved to be vital in the establishment of KM practice in these organizations, and the practice has with time been proving to be supportive in the successful management of projects. Finally, the study recommended that critical activities for adequately adopting KM enablers should be established and organizational members should further be enlightened on the importance of KM process and appropriate means for creating and sharing knowledge.