Miracle-dz/UniFAR-FTUs huggingface dataset:
Physical activity at 36 years: patterns and childhood predictors in a longitudinal study.

OBJECTIVE--The aim was to describe the sex and socioeconomic differences in patterns of physical activity at work and in leisure time of men and women aged 36 years, and to investigate factors in childhood and adolescence which predict high rates of participation in sports and recreational activities in later life. DESIGN--Data collected in childhood, adolescence, and at 36 years on members of a national prospective birth cohort study were used. SETTING--The population sample was resident in England, Scotland, and Wales. SUBJECTS--A stratified sample of about 3500 men and women was studied regularly from birth until 43 years. MEASUREMENTS AND MAIN RESULTS--More men than women reported high rates of sports and recreational activities, gardening, and do-it-yourself. In contrast women reported higher rates of bicycling and walking. Higher levels of education were associated with frequent participation in sports. Individuals often engaged in one type of activity without necessarily engaging in other types. Those who were most active in sport had been above average at sports in school, more outgoing socially in adolescence, had fewer health problems in childhood, were better educated, and had more mothers with a secondary education than those who were less active. CONCLUSIONS--Studies that examine the relationship between physical activity and chronic disease should consider a broad range of pursuits rather than extrapolating from only one area of physical activity, and in their explanations should take account of the possible role of childhood characteristics. The findings suggest the importance of developing skills and habits in childhood as well as of encouraging healthier exercise habits in adults who may have had few opportunities or low motivation previously.
Myositis Ossificans following Radical Neck Dissection

Myositis ossificans traumatica is an uncommon disorder in which there is posttraumatic bone formation in muscle and other soft tissues near bone. The lesion is exceedingly rare in the head and neck. A case is presented in which myositis ossificans of the platysma occurred following radical neck dissection. Because recurrence may follow excision of the abnormal bone, removal is recommended only if there are significant symptoms associated with the lesion. If surgery is indicated, it should be delayed for 6 to 12 months following the initial trauma to allow for maturation of the lesion.
Interaction of Adenovirus Type 5 Fiber with the Coxsackievirus and Adenovirus Receptor Activates Inflammatory Response in Human Respiratory Cells

ABSTRACT The innate immune response to adenovirus (Ad)-derived gene transfer vectors has been shown to initiate immediately after interaction of Ad with respiratory epithelial cells, through the induction of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and JNK mitogen-activated protein kinase (MAPK), nuclear factor κB (NF-κB), and different proinflammatory genes. Ad serotypes 2 or 5 (Ad2/5) enter respiratory epithelia after initial binding of fiber with the coxsackievirus-adenovirus receptor (CAR) or, alternatively, with cell surface heparan sulfate glycosaminoglycans. Ad2/5 internalization is triggered by binding of penton base to cellular RGD-binding integrins. Here we investigated the role of the Ad5 surface domain proteins constituting the vector capsid, namely, the fiber, the penton base, and the hexon, on the transmembrane signals leading to the transcription of the different proinflammatory genes in the human respiratory A549 cell line. Interaction of Ad fiber with CAR activates both ERK1/2 and JNK MAPK and the nuclear translocation of NF-κB, whereas no activation was observed after exposing A549 cells to penton base and hexon proteins. Moreover, interaction of Ad fiber with CAR, but not heparan sulfate proteoglycans, promotes transcription of the chemokines interleukin-8, GRO-α, GRO-γ, RANTES, and interferon-inducible protein 10. These results identify the binding of Ad5 fiber with the cellular CAR as a key proinflammatory activation event in epithelial respiratory cells that is independent of the transcription of Ad5 genes.
O R I G I N A L P A P E R Effects of Childhood Trauma on Hostility, Family Environment and Narcissism of Adult Individuals

Aim: This study aimed to investigate the effects of chi ldhood trauma on hostility, family functioning and narcissism in adulthood. 595 healthy individuals participated, classified into two groups ― trauma and no-trauma ― based on experienced traumatic events. Methodology: The Hostility and Direction of Hostility Questionn aire, the Aggression subscale of The Symptom Checklist-90-R, the Family Environment Scale and The Narcissistic Personality Inventory were adminis tered. Results: Higher levels of hostility (p=.040) and aggression (p=.041) were observed among participants reported exposure to a traumatic event. Apart from the confl ict subscale (p=.018), no dysfunctional family envi ronment was found. Narcissistic traits did not differ between t he two groups (p=.199). Logistic regression models found that participants experienced childhood trauma had a hig her risk of overall hostility (OR=0.92, 95% CI=.89- .99).
State policies about physical activity minutes in physical education or during school.

BACKGROUND School policies can change practices on a relatively permanent basis. This study investigated adoption and implementation of state-level policies specifying minutes (or percent) of physical activity in physical education (PE) or during school. METHODS Policies were identified from existing databases and rated as having weak, moderate, or strong wording. Interviews with state-level PE coordinators were conducted to investigate the level of implementation, monitoring, and enforcement of the identified policies. RESULTS Sixteen states had a policy that met inclusion criteria (19 policies total); 11 states had a policy addressing minutes of physical activity during school, 2 had a policy addressing percent of PE time to be spent in physical activity, and 3 had policies addressing both. None of the 19 policies were rated as having strong wording and 5 were rated as having moderate wording. The range in minutes of physical activity per week addressed in the policies was 60 to 300. Four of the 5 (elementary) and 5 of 5 (middle) policies addressing percent of PE spent physically active specified 50%. The only monitoring efforts reported consisted of schools self-reporting progress to the state. CONCLUSIONS More states need to adopt school physical activity policies and policy language needs to be more specific to prevent potential loopholes. Monitoring and evaluation strategies, beyond school self-report, are likely needed for these policies to lead to increases in physical activity.
Communicative prosody generation using language common features provided by input lexicons

We already examined language independent control characteristics of the communicative prosody generation using multi-dimensional impressions of input lexicons. In this paper, we synthesized English single phrase utterances using prosodic characteristics of Japanese speech aiming at language independent applications. The reading-style speech prosodies of English phrases were modified by prosodic characteristics derived from one-word utterance of Japanese speech “n”. Modifications were carried out based on lexical impressions corresponding to six impressions consisting of confident, doubtful, allowable, unacceptable, positive and negative. The perceptual evaluation experiment showed the naturalness of speech with communicative prosody modified by the impression of input lexicons. These experimental results support the usefulness of the communicative prosody control based on the impression of input lexicons and suggest possibilities of language independent applications.
Results from a Music, Imagery, and Movement Treatment Intervention in a Long-Term Care Facility

Results are presented from the first cohort of a music, imagery, and movement (MiM) treatment intervention study conducted with residents in a long-term care facility. The pre–post two-group treatment design randomly assigned participants to the 10-week MiM intervention or 10-week conversational social control group (N = 20). Cognitive functioning and depression were assessed for all study participants at baseline and the end of treatment. Quantitative data showed an impact of MiM on depression score reduction, and qualitative data suggested that participants engaged in meaningful interpersonal experiences within the MiM group. Together, the data suggest that creative arts participation enhances positive social engagement, which may be a key therapeutic mechanism of change acting on depression scores differentially across the MiM group versus the social control conversation group.
Çalışma Yaşamı Kalitesinin İş Memnuniyeti ve Bağlılık Üzerine Etkileri: Seyahat Acentaları Üzerine Bir Araştırma

The quality of work life reveals how an employee perceives different aspects of his/ her workplace. Such perceptions with respect to the workplace have effects on job satisfaction, the desire to work in the current organization and the desire to work in the relevant line of work for years to come. The objective of the present study is to determine which determinants of the quality of work life have significant effects on job satisfaction, commitment to the organization and line of work. Data derived from employees of travel agencies by using the questionnaire technique was analyzed by using ordinal regression technique. The factors that affect job satisfaction, commitment to organization and commitment to line of work were detected
Plasma lactate accumulation and distance running performance.

Laboratory and field assessments were made on eighteen male distance runners. Performance data were obtained for distances of 3.2, 9.7, 15, 19.3 km (n = 18) and the marathon (n = 13). Muscle fiber composition expressed as percent of slow twitch fibers (%ST), maximal oxygen consumption (Vo2max), running economy (Vo2 for a treadmill velocity of 268 m/min), and the Vo2 and treadmill velocity corresponding to the onset of plasma lactate accumulation (OPLA) were determined for each subject. %ST (R greater than or equal to .47), Vo2max (r greater than or equal to .83), running economy (r greater than or equal to .49), Vo2 in ml/kg min corresponding to the OPLA (r greater than or equal to .91) and the treadmill velocity corresponding to the OPLA (r greater than or equal to .91) were significantly (p less than .05) related to performance at all distances. Multiple regression analysis howed that the treadmill velocity corresponding to the OPLA was most closely related to performance and the addition of other factors did not significantly raise the multiple R values suggesting that these other variables may interact with the purpose of keeping plasma lactates low during distance races. The slowest and fastest marathoners ran their marathons 7 and 3 m/min faster than their treadmill velocities corresponding to their OPLA which indicates that this relationship is independent of the competitive level of the runner. Runners appear to set a race pace which allows the utilization of the largest possible Vo2 which just avoids the exponential rise in plasma lactate.
Effects of Blood Pressure Lowering in the Acute Phase of Total Anterior Circulation Infarcts and Other Stroke Subtypes

Background: Lowering of blood pressure (BP) in the acute phase of stroke is reported both to worsen and to improve the outcome. To investigate whether heterogeneity exists between stroke subtypes in the response to BP lowering, we analysed data from the Intravenous Nimodipine West European Stroke Trial (INWEST). Methods: INWEST enrolled acute ischaemic stroke patients within 24 h (n = 295) to the following groups: placebo (n = 100), 1 mg/h nimodipine (n = 101) or 2 mg/h nimodipine (n = 94). Patients were retrospectively classified as total anterior circulation infarct (TACI) (i.e. hemiparesis + hemianopia + dysphasia) and non-TACI (exclusion of any one of these). Main outcome measures were neurological (Orgogozo) and functional (Barthel) scores at day 21. Results: 106 patients were labelled as TACI and 62 as non-TACI. No significant difference in BP was observed between the TACI and non-TACI subtypes at baseline, nor did the subtypes differ in BP course within the treatment groups. A higher proportion of non-TACI patients received postrandomisation antihypertensive agents in addition to the study drug compared with TACI patients (55% non-TACI vs. 26% TACI, p < 0.005). For TACI patients, there was no outcome difference between the placebo- and nimodipine-treated groups. For non-TACI patients, placebo had a significantly better neurological (p = 0.004) and functional (p = 0.04) outcome than the high-dose nimodipine group. In multivariate analysis for TACI patients, BP reduction and nimodipine treatment had no relation with outcome. Baseline stroke severity (p < 0.005) was the only significant predictor of the outcome at day 21. For non-TACI patients, diastolic BP (DBP) reduction (p = 0.03) and nimodipine treatment (p = 0.001) were related to neurological deterioration and nimodipine treatment (p = 0.01) to functional deterioration. Systolic BP reduction was associated with neurological (p < 0.005) and functional improvement (p = 0.01). Baseline stroke severity (p < 0.005) was related to both neurological and functional outcome. Conclusion: BP lowering and nimodipine treatment had no significant effect on outcome for TACI patients. For non-TACI patients, DBP lowering worsened the neurological outcome and high-dose nimodipine worsened both the neurological and functional outcome.
Aging Mice Show a Decreasing Correlation of Gene Expression within Genetic Modules

In this work we present a method for the differential analysis of gene co-expression networks and apply this method to look for large-scale transcriptional changes in aging. We derived synonymous gene co-expression networks from AGEMAP expression data for 16-month-old and 24-month-old mice. We identified a number of functional gene groups that change co-expression with age. Among these changing groups we found a trend towards declining correlation with age. In particular, we identified a modular (as opposed to uniform) decline in general correlation with age. We identified potential transcriptional mechanisms that may aid in modular correlation decline. We found that computationally identified targets of the NF-ΚB transcription factor decrease expression correlation with age. Finally, we found that genes that are prone to declining co-expression tend to be co-located on the chromosome. Our results conclude that there is a modular decline in co-expression with age in mice. They also indicate that factors relating to both chromosome domains and specific transcription factors may contribute to the decline.
A New Approach to Improving Multilingual Summarization Using a Genetic Algorithm

Automated summarization methods can be defined as "language-independent," if they are not based on any language-specific knowledge. Such methods can be used for multilingual summarization defined by Mani (2001) as "processing several languages, with summary in the same language as input. " In this paper, we introduce MUSE, a language-independent approach for extractive summarization based on the linear optimization of several sentence ranking measures using a genetic algorithm. We tested our methodology on two languages---English and Hebrew---and evaluated its performance with ROUGE-1 Recall vs. state-of-the-art extractive summarization approaches. Our results show that MUSE performs better than the best known multilingual approach (TextRank) in both languages. Moreover, our experimental results on a bilingual (English and Hebrew) document collection suggest that MUSE does not need to be retrained on each language and the same model can be used across at least two different languages.
Molecular characterization and regulation of the rhizosphere-expressed genes rhiABCR that can influence nodulation by Rhizobium leguminosarum biovar viciae

A group of four rhi (rhizosphere-expressed) genes from the symbiotic plasmid of Rhizobium leguminosarum biovar viciae has been characterized. Although mutation of the rhi genes does not normally affect nodulation, in the absence of the closely linked nodulation genes nodFEL, mutations in the rhi genes can influence the nodulation of the vetch Vicia hirsuta. The DNA sequence of the rhi gene region reveals four large open reading frames, three of them constituting an operon (rhiABC) transcribed convergently toward the fourth gene, rhiR. rhiABC are under the positive control of RhiR, the expression of which is repressed by flavonoids that normally induce nod gene expression. This repression, which requires the nodD gene product (the transcriptional activator of nod gene expression), may be due to a cis effect caused by a high level of NodD-dependent expression from the adjacent nodO promoter, which is transcribed divergently from rhiR. RhiR shows significant similarities to a subfamily of transcriptional regulators that includes the LuxR and UvrC-28K proteins. RhiA shows limited homology to a short domain of the lactose permease, LacY, close to a region thought to be involved in substrate binding. No strong homologies were found for the other rhi gene products. It appears that RhiA and RhiB are cytoplasmic, whereas RhiC is a periplasmic protein, since it has a typical N-terminal transit sequence and a rhiC-phoA protein fusion expresses alkaline phosphatase activity. The biochemical role of the rhi genes has not been established, but it appears that they may play a role in the plant-microbe interaction, possibly by allowing the bacteria to metabolize a plant-made metabolite.
Fully automated facial picture evaluation using high level attributes

People automatically and quickly judge a facial picture from its appearance. Thus, developing tools that can reproduce human judgments may help consumers in their picture selection process. Previous work mostly studied the position of facial keypoints to make predictions about specific traits: trustworthiness, likability, competence, etc. In this work, high level attributes (e.g. gender, age, smile) are automatically extracted using 3 different tools and are used to build models adapted to each trait. Models are validated on a set of synthetic images and it is shown that using attributes increases significantly the correlation between human and algorithmic evaluations. Then, a new dataset of 140 images is presented and used to demonstrate the relevance of high level attributes for evaluating faces with respect to likability and competence. A model combining both facial keypoints and attributes is finally proposed and applied to picture selection: which picture depicts the most likable face for a given person?
Binary locally repairable codes from complete multipartite graphs

In this paper, we propose a construction of binary locally repairable codes from complete multipartite graphs. Our codes possess joint locality (r1 = 2, r2 = 3 or 4). Joint locality is a set of numbers of symbols for repairing various erasure patterns of symbols. We also provide availability properties of our codes. A code is said to have (r, t)-availability if each of its symbols can be repaired by t disjoint groups of other symbols, each of a size of at most r. As a meaningful result, the proposed code construction can generate binary locally repairable codes achieving (2, t)-availability for any positive integer t.
Molecular Medicine in Practice Epithelial – Mesenchymal Transition Predicts Sensitivity to the Dual IGF-1 R / IR Inhibitor OSI-906 in Hepatocellular Carcinoma Cell Lines

Agrowingbodyofdata indicates that inhibiting the type 1 insulin-like growth factor receptor (IGF-1R)might be an effective treatment strategy for hepatocellular carcinoma (HCC). OSI-906 is a dual IGF-1R/IR kinase inhibitor currently in phase II clinical development for HCC.However, biomarkers are lacking to help identify patients withHCCwho aremore likely to benefit fromOSI-906 treatment.We sought to determine the effect of OSI-906 on proliferation against a panel of 21 HCC cell lines and to investigate molecular determinants of responsiveness toOSI-906.We identified a subset ofHCCcell lines thatwas sensitive toOSI-906, and sensitivity is associated with elevated phosphorylation levels of IGF-1R and IR and greater inhibition of AKT signaling. Dual targeting of both receptors seems to be important formaximal inhibition as treatmentwith a selective IGF1R–neutralizing antibody was associated with increased IR signaling, whereas OSI-906 fully inhibited both phosphorylated IR and IGF-1R and resulted in greater inhibition of the IRS/AKT pathway. Epithelial– mesenchymal transition (EMT) seems to predict HCC cell sensitivity to OSI-906, as the epithelial phenotype is strongly associated with expression of IGF-2 and IR, activation of IGF-1R and IR, and sensitivity to OSI-906, alone or in combinationwith erlotinib. Induction of EMTupon treatmentwithTGFb reduced sensitivity toOSI906. Collectively, these data support the concept for dual IGF-1R/IR targeting in HCC, where EMT status and expressions of IGF-2 and IRmaybeused to identify those patientswho aremost likely to benefit from treatment with an IGF-1R/IR dual inhibitor. Mol Cancer Ther; 11(2); 503–13. 2011 AACR.
Environmental and Physiological Controls of Blue Crab Avoidance Behavior During Exposure to Hypoxia

Generalizing the impacts of hypoxia on aquatic animal populations is difficult due to differences in behavioral and physiological responses among individuals as well as varying hydrodynamics of hypoxic events. Information on which environmental cues animals use to avoid hypoxia and how abiotic covariates and physiology influence avoidance behavior is lacking. Our laboratory flume studies quantified the interacting effects of hydrography (dissolved oxygen [DO], temperature, and salinity), hydrodynamics (rate of DO decline and current speed), and physiological state on avoidance behaviors of blue crabs (Callinectes sapidus). Changes in DO stimulated increased rates of movement, regardless of whether the change resulted in hypoxia. Increased rates of DO decline stimulated faster movement rates under hypoxic conditions because crabs spent less time in hypoxia compared to crabs under conditions of slow rate of DO decline. Blue crabs that had hemocyanin structures with a high affinity for O2 (hypoxia-tolerant) were less active under hypoxic conditions than conspecifics with hemocyanins with a low O2 affinity, suggesting that physiological state influences behavioral responses to stressors. These results provide a mechanistic understanding of how physiological acclimation and hypoxia hydrodynamics may influence population dynamics.
On the Measurement of Event-Based Object-Oriented Conceptual Models

A suite of measures is presented that addresses two problem areas within contemporary object-oriented software measurement, i.e. the lack of measures for the early stages of system development, like conceptual modeling, and the lack of measures for dynamic models of an object-oriented system. Our suite of measures is based on a formally defined object-interaction model, called the object-event table. Generally, the objects in a domain are affected by the occurrence of real-world events. A framework for measurement is presented that expresses and measures aspects of the data, function and dynamic behaviour dimensions of a domain, in terms of (common) event participations.