Miracle-dz/UniFAR-FTUs huggingface dataset:
Androgen receptors mediate hypertrophy in cardiac myocytes.

BACKGROUND The role of androgens in producing cardiac hypertrophy by direct action on cardiac myocytes is uncertain. Accordingly, we tested the hypothesis that cardiac myocytes in adult men and women express an androgen receptor gene and that myocytes respond to androgens by a hypertrophic response. METHODS AND RESULTS We used reverse transcription-polymerase chain reaction methods to demonstrate androgen receptor transcripts in multiple tissues and [3H]phenylalanine incorporation and atrial natriuretic peptide secretion as markers of hypertrophy in cultured rat myocytes. Messenger RNA encoding androgen receptors was detected in myocytes of male and female adult rats, neonatal rat myocytes, rat heart, dog heart, and infant and adult human heart. Both testosterone and dihydrotestosterone produced a robust receptor-specific hypertrophic response in myocytes, determined by indices of protein synthesis and atrial natriuretic peptide secretion. CONCLUSIONS Androgen receptors are present in cardiac myocytes from multiple species, including normal men and women, in a context that permits androgens to modulate the cardiac phenotype and produce hypertrophy by direct, receptor-specific mechanisms. There are clinical implications for therapeutic or illicit use of androgens in humans.
Terascale direct numerical simulations of turbulent combustion using S3D

Computational science is paramount to the understanding of underlying processes in internal combustion engines of the future that will utilize non-petroleum-based alternative fuels, including carbon-neutral biofuels, and burn in new combustion regimes that will attain high efficiency while minimizing emissions of particulates and nitrogen oxides. Next-generation engines will likely operate at higher pressures, with greater amounts of dilution and utilize alternative fuels that exhibit a wide range of chemical and physical properties. Therefore, there is a significant role for high-fidelity simulations, direct numerical simulations (DNS), specifically designed to capture key turbulence-chemistry interactions in these relatively uncharted combustion regimes, and in particular, that can discriminate the effects of differences in fuel properties. In DNS, all of the relevant turbulence and flame scales are resolved numerically using high-order accurate numerical algorithms. As a consequence terascale DNS are computationally intensive, require massive amounts of computing power and generate tens of terabytes of data. Recent results from terascale DNS of turbulent flames are presented here, illustrating its role in elucidating flame stabilization mechanisms in a lifted turbulent hydrogen/air jet flame in a hot air coflow, and the flame structure of a fuel-lean turbulent premixed jet flame. Computing at this scale requires close collaborations between computer and combustion scientists to provide optimized scaleable algorithms and software for terascale simulations, efficient collective parallel I/O, tools for volume visualization of multiscale, multivariate data and automating the combustion workflow. The enabling computer science, applied to combustion science, is also required in many other terascale physics and engineering simulations. In particular, performance monitoring is used to identify the performance of key kernels in the DNS code, S3D and especially memory intensive loops in the code. Through the careful application of loop transformations, data reuse in cache is exploited thereby reducing memory bandwidth needs, and hence, improving S3D's nodal performance. To enhance collective parallel I/O in S3D, an MPI-I/O caching design is used to construct a two-stage write-behind method for improving the performance of write-only operations. The simulations generate tens of terabytes of data requiring analysis. Interactive exploration of the simulation data is enabled by multivariate time-varying volume visualization. The visualization highlights spatial and temporal correlations between multiple reactive scalar fields using an intuitive user interface based on parallel coordinates and time histogram. Finally, an automated combustion workflow is designed using Kepler to manage large-scale data movement, data morphing, and archival and to provide a graphical display of run-time diagnostics.
Inductively coupled plasma-induced damage in AlGaN/GaN HEMTs

The effect of damage induced by Ar + ion bombardment on two-dimensional electron gas (2DEG) in AlGaN/GaN high electron mobility transistor (HEMT) structure at different bias voltages using an inductively coupled plasma system was studied. The samples were measured before and after etching with respect to mobility and sheet carrier concentration. The value of the bias voltage significantly affected the plasma-induced damage on two-dimensional electron gas properties. However, plasma-induced damage could be easily annealed out by rapid thermal annealing the samples for just 5 s at 500°C.
GenAlyzer: interactive visualization of sequence similarities between entire genomes

SUMMARY Genalyzer is a software tool designed for the interactive visualization of sequence matches between DNA or protein sequences. It provides visualizations on different levels of granularity, from complete overviews via zoomed regions to alignments of particular matching substrings. Genalyzer can efficiently handle very large datasets, allowing to display tens of thousands of matches between sequences of tens of millions of bases. AVAILABILITY Genalyzer is available free of charge for non-commercial research institutions. For more details, see http://www.genalyzer. de
Introduction to Fine Ceramics

Introduction to Fine Ceramics: Applications in Engineering, edited by N. Ichinose is written, according to the editor, with the aim of providing an illustrative, easy-to-understand book on this subject. This all Japanese authored book on fine ceramics or functional ceramics addresses an important subject in which the Japanese have a commanding position both in research and technology development. The Japan's Ministry of International Trade and Industry (MITI) made a commitment in 1981 to promote and develop fine ceramics as part of its next generation industrial technology development program. About the same time, the manufacturers and users of fine ceramics formed the Fine Ceramic Society to promote research and information exchange in manufacture and utilization, market research, technology development, and international exchange. The Japanese strongly believe that fine ceramics technology has great potential and are working diligently to exploit it. Engineering ceramic materials are becoming increasingly more important to a growing number of industries including electrical, electronic, mechanical, and biomedical. Using a question and an answer format, various authors of this book have addressed several phenomena associated with ceramics and gave examples of practical applications of fine ceramics with the hope of providing engineers and materials scientists a better appreciation of the field. The 160 page book is divided into the following 5 chapters, a table of contents, and an index.
LP-W- $\ell _{\infty }$ -SVD Algorithm for Direction-of-Arrival Estimation

This paper presents an effective direction-of-arrival (DOA) estimation method based on a new computation method of the ℓ∞-norm for a complex matrix. Making use of the new computation method of the ℓ∞-norm, the DOA estimation problem can be efficiently formulated as a linear programming (LP) problem. Thus, the proposed method can effectively give the DOA estimation by finding the sparse coefficients which are obtained by solving the LP problem. Except for the first singular value decomposition of the data matrix, the proposed method is effectively implemented in the light of the LP theory based on real-valued computation. It avoids solving the complicated second-order cone programming problem. Furthermore, it can primely suppress spurious peaks in DOA estimation. Simulation results demonstrate the efficiency of the presented approach.
Current-mode quadrature oscillator using minimum elements

This paper presents a new current-mode quadrature oscillator employing only a single current-controlled current conveyor transconductance amplifier, two grounded capacitors and one grounded resistor. The circuit is beneficial to monolithic integrated circuit implementation by using grounded capacitors. The oscillation condition and the oscillation frequency can be independently controlled. The oscillation frequency can also be controlled electronically by adjusting the bias currents. The realized of the circuit provides explicit quadrature voltage and current outputs. Simulation results that confirm the theoretical predictions are also given.
A Design of Greenhouse Monitoring & Control System Based on ZigBee Wireless Sensor Network

The wireless sensor network (WSN) is one of the most significant technologies in the 21st century. As an open and global standard for WSN, ZigBee shows advantages on low-cost, low power consumption and self-forming. The current researches of ZigBee wireless sensor network on industrial automation, electronic products, smart buildings and medical care were presented and, as an explorative application of ZigBee wireless sensor network in protected agriculture overcoming the limits of wire connection, its applied design for greenhouse management was proposed by introducing both the hardware and software architectures. The node power consumption was also discussed. Finally, the architecture of ZigBee-based mesh network greenhouse management was indicated.
Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis

Poly(ADP-ribosyl)ation is an unique posttranslational modification and required for spindle assembly and function during mitosis. However, the molecular mechanism of poly(ADP-ribose) (PAR) in mitosis remains elusive. Here, we show the evidence that PAR is recognized by ECT2, a key guanine nucleotide exchange factor in mitosis. The BRCT domain of ECT2 directly binds to PAR both in vitro and in vivo. We further found that α-tubulin is PARylated during mitosis. PARylation of α-tubulin is recognized by ECT2 and recruits ECT2 to mitotic spindle for completing mitosis. Taken together, our study reveals a novel mechanism by which PAR regulates mitosis.
Containment join size estimation: models and methods

Recent years witnessed an increasing interest in researches in XML, partly due to the fact that XML has now become the de facto standard for data interchange over the internet. A large amount of work has been reported on XML storage models and query processing techniques. However, few works have addressed issues of XML query optimization. In this paper, we report our study on one of the challenges in XML query optimization: containment join size estimation. Containment join is well accepted as an important operation in XML query processing. Estimating the size of its results is no doubt essential to generate efficient XML query processing plans. We propose two models, the interval model and the position model, and a set of estimation methods based on these two models. Comprehensive performance studies were conducted. The results not only demonstrate the advantages of our new algorithms over existing algorithms, but also provide valuable insights into the tradeoff among various parameters.
IN VITRO GROWTH OF MELALEUCA ALTERNIFOLIA CHEEL IN BIOREACTOR OF IMMERSION BY BUBBLES

Development of new techniques for in vitro culture is necessary to optimize and reduce the production costs. The aim of this work was to introduce the bioreactor BIB ® (Bioreactor of Immersion by Bubbles) and compare it with conventional culture and bioreactor RITA ® (Recipient with Automatized Temporary Immersion) for In vitro growth of M. alternifolia plantlets. Plantlets with 1.0 cm height from the fifth In vitro subculture were used. Treatments were: (1) conventional culture (control) using 200 mL glass flasks covered with polypropylene lids; (2) bioreactor RITA ® and (3) bioreactor BIB ® . Continuous immersion and aeration was used in bioreactors. It was used liquid MS medium supplemented with 30 g.L -1 sucrose and 1 drop.200 mL -1 Tween 20 ® (i.e. detergent for bubbles formation). BIB ® obtained best results for total fresh mass (0.39 g) and shoot fresh mass (0.27 g), fresh mass increment (3.1), total dry mass (0.036 g) and shoot dry mass (0.033 g) than RITA ® and conventional culture. In conclusion, BIB ® is more efficient to the biomass accumulation of M. alternifolia plantlets.
Using a Practical Approach for Determining the Most Effective Stretching Strategy in Female College Division I Volleyball Players

Abstract Kruse, NT, Barr, MW, Gilders, RM, Kushnick, MR, and Rana SR. Using a practical approach for determining the most effective stretching strategy in female college division I volleyball players. J Strength Cond Res 27(11): 3060–3067, 2013—The purpose of this investigation was to quantify the effects that a practical bout of static stretching (SS) and dynamic stretching (DS) has on maximal countermovement jump (CMJ) height across a time spectrum of 25 minutes in National Collegiate Athletic Association Division I varsity volleyball players. Eleven female varsity volleyball players (mean ± SD; age 20.00 ± 1.55 years; height 1.78 ± 0.08 m; mass 74.55 ± 12.18 kg) volunteered for this investigation. Three days of randomized experimental testing (SS, DS, control) were completed. The SS protocol consisted of stretching 7 muscle groups. The DS protocol consisted of the volleyball team's actual DS routine of equal duration (30 seconds) to SS. Poststretch performance measures of CMJ were determined at 1, 5, 15, and 25 minutes poststretch. Countermovement jump had an acute significant trial-by-time interaction, indicating that DS was found to produce significantly higher scores than the SS and control session at 1 and 5 minutes poststretch, but not at 15 and 25 minutes poststretch. Additionally, there was a timing interaction within trials where SS scores were significantly lower at 1minute poststretch compared with 5 and 25 minutes poststretch, and DS scores were significantly higher at 1 and 5 minutes poststretch compared with 15 and 25 minutes poststretch. Athletes engaging in competitive power sports should continue to utilize their DS routine but may need to do so within 5 minutes before activity.
Laser-induced damage of SiO2 and CaF2 under 263 nm

Laser damage performance of large aperture optical components has been study under fourth harmonic of 1053nm Nd:glass laser irradiation (263nm). The threshold of optical components is very low under 263nm laser irradiation ,due to conversion of beam to higher energy photons of the quadrupled frequency (4ω), and is relative to material characteristic. A preliminary test of laser induced damage in fused silica (SiO2) and CaF2under 263nm laser is reported in this article. Thresholds of these two materials are obtained. Laser damage threshold of SiO2 is found about 2 J/cm2 by 1-on-1 method using pulsed 263nm laser, lower than CaF2 whose threshold.
Application of automatic thesaurus extraction for computer generation of vocabulary questions

Automatic thesaurus extraction techniques are applied to computer-generated related word vocabulary questions. These questions assess and provide practice for an aspect of word knowledge found to be important for language learning. Automatic generation of such questions reduces the need for human authoring of practice materials. In evaluations with real teachers, most of the generated questions were considered to be usable in real classrooms. Also, performance of native and nonnative speakers on these automatically generated questions was similar to their performance on manually generated questions for the same words. This application of natural language processing techniques to English as a Second language education is a promising step toward automatically producing vocabulary practice and assessment materials for language learners.
Short-term Memory to Long-term Memory Transition in a Nanoscale Memristor

A memristor 1À3 is a two-terminal device whose conductance can be modulated by external inputs with a memory effect due to internal state changes. Its concept 1 was first proposed 40 years ago and was recently linked to physical devices. 2 Like other nonlinear devices, a memristor is controlled by a (or a set of) internal state variable(s) which is in turn modulated by input signals. However, for a memristor the input signals at a given moment only determine the time derivative of the state variable, and the device state can be sufficiently determined only after knowing the history of the inputs. Mathematically, a memristor device is described by a set of equations that includes a current equation (eq 1) and a rate equation (eq 2): 3 i ¼ G(w, v)v (1) dw=dt ¼ f (w, v) (2) Here G is the conductance linking the current and voltage, w is the internal state variable discussed above, and f is a function describing the change of w as a function of inputs and the current state. We note strictly speaking that eqs 1 and 2 describe a general class of memristive devices, 3 and here we use the term mem-ristor to represent this general class of devices simply for the convenience of discussion without losing mathematical rigor-ousness. Despite its deceivingly simple two-terminal structure, a memristor can exhibit very complex behaviors when different terms are incorporated into the current equation and, in particular, the rate equation. For example, it has been concluded that all two-terminal nonvolatile memory devices based on resistive switching effects, that is, resistive random access memories (RRAM), are essentially memris-tors, regardless of materials or physical mechanisms utilized. 4 The flexibility and generality of the mem-ristor model allow the device to be used in a wide range of applications. As an example, RRAM has been studied as a leading candidate in nonvolatile memory applications 5 as a replacement for the flash memory technology due to attributes such as high density, 6,7 fast operation, 8,9 low power, 8 and CMOS compatibility. 9 Digital memory devices have been achieved in various materi-increase of storage density. Recently, mem-ristors have also been studied in biologically inspired neuromorphic circuits. 14À17 Important synaptic learning rules such as spike-timing dependent plasticity (STDP) have already been demonstrated. 15À17 However, to build successful artificial neural networks, a number of important synaptic functionalities remain to be achieved. One such example …
Fibre Waviness Generation and Measurement and Its Effect on Compressive Strength

Artificial fibre waviness was produced by laying up unidirectional carbon fibre-epoxy on a curved plate, and then straightening it before curing. A technique was developed for measuring out-of-plane waviness using a surface displacement transducer mounted on a traversing table. Measurements within the laminate were made by splitting it open along ply interfaces treated with release agent prior to curing. Typical maximum misalignment angles at the centre of a 2 mm thick panel were in the range 0.7 to 1 degree. In-plane waviness data was also generated by splitting the plies along the fibre direction. Tests in a pin-ended buckling rig gave compressive failures with reductions of compressive and tensile surface strain of only 17% and 26%, despite in-plane misalignments of up to 24 degrees in the surface plies.
Nutrition in pregnant or lactating rats programs lipid metabolism in the offspring

Epidemiological studies in humans show that size in early life is related to blood cholesterol concentrations in adult life, raising the hypothesis that early nutrition programs later lipid metabolism, affecting risk for later vascular disease. Here, we tested the hypothesis that nutrition during pregnancy or lactation in the rat programs lipid metabolism in the offspring, studied in adult life (mean 6 months). Rats (n 35) from normally-fed dams (controls) were compared with (1) rats (n 22) from dams protein-restricted in pregnancy and lactation; (2) rats (n 9) born to normally-fed mothers crossed to protein- restricted lactating dams and (3) those (n 9) born of protein-restricted dams and crossed to normally-fed lactating animals. In these latter three groups the offspring showed long-term reduction in plasma cholesterol, HDL-cholesterol and triacylglycerol concentrations compared with controls. The effects were predominantly in males. These findings suggest that in the rat the sensitive period for nutritional programming of cholesterol and triacylglycerol metabolism is both pre- and postnatal (pre-weaning) and that rats may be ‘indirectly’ programmed by altering the maternal nutritional milieu during gestation or lactation. whilst it has been hypothesized that early human undernutrition programs risk for vascular disease, one aspect of undernutrition, low maternal protein intake, in this rat model programmed lower plasma cholesterol and triacylglycerol concentrations.
Adjuvant postoperative radiation therapy for colorectal carcinoma above the peritoneal reflection II. Antimesenteric wall ascending and descending colon and cecum

From 1970 to 1981, 50 patients had curative surgery for carcinoma of the cecum, ascending, or descending colon and were Stage ≥B2. In 15 cases, the lesion originated on the antimesenteric (posterolateral) bowel wall. Of seven cases (with minimum three‐year follow‐up) not receiving adjuvant postoperative regional irradiation, four recurred in the tumor bed/abdominal wall versus 0/3 irradiated patients. Similarly, the five‐year survival was improved in the irradiated group (2/3) versus only 2/9 in the unirradiated group. Patients with transmural extension of right or left colon cancers originating on the anti mesenteric (posterolateral) bowel wall may have a high incidence of postoperative regional failure which may be decreased by adjuvant postoperative regional irradiation.
An Architecture for Network Layer Privacy

We present an architecture for the provision of network layer privacy based on the SHIM6 multihoming protocol. In its basic form, the architecture prevents on-path eavesdroppers from using SHIM6 network layer information to correlate packets that belong to the same communication but use different locators. To achieve this, several extensions to the SHIM6 protocol and to the HBA (Hash Based Addresses) addressing model are defined. On its full-featured mode of operation, hosts can vary dynamically the addresses of the packets of on-going communications. Single-homed hosts can adopt the SHIM6 protocol with the privacy enhancements to benefit from this protection against information collectors.
Nonvolatile Multilevel Resistive Switching Memory Cell: A Transition Metal Oxide-Based Circuit

We study the resistive switching (RS) mechanism as a way to obtain multilevel cell (MLC) memory devices. In an MLC, more than 1 b of information can be stored in each cell. Here, we identify one of the main conceptual difficulties that prevented the implementation of RS-based MLCs. We present a method to overcome these difficulties and to implement a 6-b MLC device with a manganite-based RS device. This is done by precisely setting the remnant resistance of the RS device to an arbitrary value. Our MLC system demonstrates that transition metal oxide nonvolatile memory devices may compete with currently available MLCs.