Miracle-dz/UniFAR-FTUs huggingface dataset:
Role modelling GSF principles of end-of-life care to care homes

Residents in care homes providing nursing care are becoming increasingly frail and dependent, with 80% having dementia or severe memory problems. Currently, 19% of the UK population die in care homes each year. Care homes (especially care homes providing nursing care) have an important role in the care of dying residents and are now expected to provide good end-of-life care (EoLC). Implementing EoLC tools, such as the Gold Standards Framework (GSF) and the Liverpool Care Pathway for the Dying Patient, can provide a structure upon which to improve the quality of EoLC. However, some care homes, despite completing the GSF programme, find it difficult to implement the measures required to provide optimal EoLC. This article reflects on the author’s experiences over a 2-year period of working alongside such care homes. It describes how she focused on four aspects of EoLC to help support the staff: dignity in care; advance care planning; care of the dying resident using an integrated care plan for the last days of life; and assessment and management of pain and depression using specified tools. Conflicts of interest: none
Managing the Tide: How Do Emerging Markets Respond to Capital Flows?

This paper examines whetherâ€”and howâ€”emerging market economies (EMEs) respond to capital flows to mitigate their untoward consequences. Based on a sample of about 50 EMEs over 2005Q1â€“2013Q4, we find that EME policy makers respond proactively to capital inflows by using a combination of policy tools: central banks raise the policy interest rate to address economic overheating concerns; intervene in the foreign exchange market to resist currency appreciation pressures; tighten macroprudential measures to dampen credit growth; and deploy capital inflow controls in the face of competitiveness and financial-stability concerns. Contrary to conventional policy advice to EMEs, we find no evidence of counter-cyclical fiscal policy in the face of capital inflows. Overall, policies are more likely to respond, and used in combination, during inflow surges than in more normal times.
Oral health-related quality of life in patients treated by implant-supported fixed dentures and removable partial dentures.

OBJECTIVES This study investigated the association between denture status [implant-supported fixed dentures (IDs) and removable partial dentures (RPDs)] and oral health-related quality of life (OHRQoL). MATERIALS AND METHODS Consecutive patients with IDs and RPDs were recruited from the Prosthodontics Departments at Showa University and Tokyo Medical and Dental University. The Japanese version of the Oral Health Impact Profile (OHIP-J-49) was administered to each subject. For each OHIP-J-49 question, the subjects were asked to indicate the frequency with which they had experienced a dental problem during the last month. Responses were recorded on a 5 point Likert rating scale, with 0 being never and 4, very often. Summary scores were calculated and regression analyses conducted to investigate the association between denture status and OHIP-J-49 summary score. RESULTS In total 79 ID subjects (mean age±SD of 51.7±12.4 years, 44.3% men) and 109 RPD subjects (mean age of 66.5±8.6 years, 30% men) participated after giving informed consent. The regression analysis between the type of treatment and the OHIP-J-49 summary score revealed a significant association with a coefficient of 17.0 (Confidence interval, CI: 10.9-23.1). When age and duration of denture usage, which had significant associations with OHIP-J-49, were included in this model, the regression coefficient remained virtually unchanged at 17.4 (CI: 9.75-25.0), thus indicating little potential confounding by them. CONCLUSIONS OHRQoL in patients with implant-supported fixed dentures is generally less impaired than it is in those patients with RPDs.
Robust Clipping Noise Cancellation Based on Location-Aware Compressed Sensing

For OFDM systems, to cope with the remain problems of high complexity and low performance in conventional clipping noise cancellation methods, a robust scheme based on location-aware compressed sensing (CS) and phase correction is proposed in this paper. Based on CS theory, a simple and configurable selection criterion is utilized to choose reliable observations for the clipping noise reconstruction. The transceiver is redesigned to transmit both the data and the clipping location. With the aid of clipping location information and phase information from the receiver, the proposed scheme improves both the accuracy and computational complexity. Simulation results show that the proposed scheme achieves excellent performance even in low signal-to-noise ratio (SNR) environments. Besides, due to the low computational complexity and excellent adaptivity, the proposed scheme is more feasible in practical engineering applications than other CS-based methods.
Pulmonary marginal zone lymphoma: A single centre experience and review of the SEER database

Pulmonary marginal zone lymphoma is a rare disease arising from bronchial-associated lymphoid tissue (BALT). There is limited information on clinical presentation, natural history and treatment of this type of lymphoma. We conducted a retrospective review of patients with biopsy-proven BALT lymphoma treated at our institution and patients from the surveillance epidemiology and end results (SEER) database. Twenty-one patients (median age 57) with disease stage IE (n = 10) and IV (n = 11), were treated at our institution. Initial management included observation (n = 4), surgery (n = 5), combination chemotherapy (n = 7), single-agent rituximab (n = 3) and radioimmunotherapy (n = 2). Complete remission was observed in 10, partial remission in 3, stable disease in 7, and disease progression in 1 patient. With a median follow-up of 20 months, Kaplan–Meier estimates for progression-free and overall survival (OS) at 80 months were 90% and 95%, respectively. We identified 326 patients (59% females and 41% males; median age 68 [30 to 85) with BALT lymphoma in the SEER database. Fifty-five per cent had stage IE, 10% stage IIE, 3% stage IIIE, and 22% stage IV disease. After a median follow-up of 35 months, median OS was 112 months, and disease-specific median survival was not reached. At 90 months, disease-specific survival was 85% (CI 77-92) with no significant differences in outcome between patients presenting with different stages. Our single institution experience and review of the SEER database, confirm the indolent features and favourable outcome of this rare disease.
Identification and in silico characterization of a novel compound heterozygosity associated with hereditary aceruloplasminemia

Background. Hereditary aceruloplasminemia is an adult-onset autosomal recessive disease characterized by increased iron overload in the liver, pancreas, retina, and central nervous system. So far, 45 families with cases of aceruloplasminemia have been reported world-wide and mainly missense and nonsense mutations in the ceruloplasmin gene were detected. Material and methods. Here, we report the identification, clinical characterization, and in silico analysis of a novel compound heterozygosity in the ceruloplasmin gene of a 31-year-old man with iron overload. Results. Increased serum ferritin levels, elevated iron saturation, as well as results of iron quantification in the liver and magnetic resonance imaging-based measurement of T2 relaxation times of the substantia nigra consistently suggested iron overload. By sequencing the ceruloplasmin gene, so far unknown nucleotide replacements G229C, and C2131A were detected in exons 2 and 12, respectively. In silico analyses showed that the resulting amino acid changes Asp58His and Gln692Lys are located at highly conserved positions. The Asp58His mutation is located on the surface of the protein, alters polarity, and may interfere with copper incorporation or ceruloplasmin trafficking. The Gln692Lys mutation is mapped to a β-strand of domain 4 and may lead to conformational change of the cupredoxin fold. Conclusions. As causative for aceruloplasminemia, a formerly unknown compound heterozygosity in the ceruloplasmin gene was identified. In silico characterization suggests an impact on ceruloplasmin conformation and function.
Business angel investment decision-making criteria

OBJECTIVES OF THE STUDY The purpose of the thesis is to provide new evidence and address the partially lacking understanding of business angel decision-making. This thesis studies the issue by investigating both the investment criteria and the rejection criteria business angels use to decide whether an opportunity should advance beyond the initial screening stage to the due diligence. The study focuses on the pitch meetings, in which entrepreneurs try to sell their ideas and equity to business angels in exchange for capital.
A Study on Factors influencing the adoption of Content Marketing by Small and Medium Enterprises (SMEs) in India

The main objective of this study is to determine the factors influencing the content marketing adoption by Small and Medium sized Enterprises (SMEs) in India. Based on two dominant theories in the field of diffusion of innovation, a conceptual model is proposed. In order to test the model empirically, an online survey was designed and launched. Decision makers of 400 SMEs agreed to participate in this survey. In order to evaluate the internal, convergent and discriminant validity of the instrument, factor analysis and reliability tests of panel data were performed. The logistic regression analysis was deployed to test the research hypotheses. The results of regression analysis reveal that Relative Advantage, Employees Knowledge, Competitive Pressure and Level of Innovativeness are the main influential factor in adopting content marketing.
Efficient tools to target DNA to Podospora anserina

Because, in filamentous fungi, integration of transgenes proceeds mainly through nonhomologous recombination, transformation results in a random distribution of these DNA sequences. Moreover, they are often found as multiple copies clustered at a single locus. Therefore, for a given transgene, expression may be highly variable among independent transformants. To get rid of both multiple copies and position effects, due to the impact of the chromatin structure upon transgene expression, we constructed tools to specifically target single copies at two well-defined loci, Pa_2_3690 and Pa_4_5450 (Espagne et al., 2008). These genes have been chosen for the following reasons: (1) they have a relatively stable expression during the entire Podospora’s life cycle, (2) complete deletion of their ORF does not lead to an abnormal phenotype (Bidard et al., 2011), (3) they are located on two different chromosomes and (4) their second division segregation (SDS) frequency is 80% and 90%, respectively. Besides, a highly efficient homologous recombination ΔPaKu70 strain is available (El-Khoury et al., 2008), which makes gene replacement fairly easy. Taking advantage of this strain, we designed two plasmid tools to target genomic integration of any DNA fragment.
Tracking Social Networks Events

—Online social media represent a fundamental shift of how information is being produced, transferred and consumed. User generated content in the form of blog posts, comments, and tweets establishes a connection between information producers and consumers. Tracking the pulse of the social media outlets enables companies to gain feedback and insight in how to improve and market products better. For consumers, the abundance of information and opinions from diverse sources helps them make more informed decisions. However, the huge level of online interactions leads to permissive usage behaviours, opening the door for viruses, worms, trojan horses and other threats to install and easily spread, without being noticed. Being able to track users activities, organize the retrieved information in a comprehensive way and analyze it can be very useful for several management, engineering and security tasks. This paper proposes a framework to collect social network events and store them in a relational database for posterior analysis. A graphical user interface was developed to allow ﬂexible access to stored information, according to the type of event, thus facilitating the analysis of users behaviours. From a privacy perspective, the proposed framework is not intrusive because it only gathers the actions timestamps and not their complete contents. By computing statistical models over the obtained data, it is possible to deﬁne ”normal or typical” usage proﬁles and detect possible deviations that can be indicative of a compromised user account.
Researching breathlessness in palliative care: consensus statement of the National Cancer Research Institute Palliative Care Breathlessness Subgroup

Breathlessness is common in advanced disease and can have a devastating impact on patients and carers. Research on the management of breathlessness is challenging. There are relatively few studies, and many studies are limited by inadequate power or design. This paper represents a consensus statement of the National Cancer Research Institute Palliative Care Breathlessness Subgroup. The aims of this paper are to facilitate the design of adequately powered multi-centre interventional studies in breathlessness, to suggest a standardised, rational approach to breathlessness research and to aid future ‘between study’ comparisons. Discussion of the physiology of breathlessness is included.
Hyperspectral image classification via region-based composite kernels

This paper presents a region-based composite kernel framework for spatial-spectral hyperspectral image classification, referred as RCK, by exploiting the local similarities of both the spectral and spatial features via superpixel segmentation. The proposed framework consists of three steps. In the first step, the original hyperspectral image together with its spatial feature image are segmented into several nonoverlapping regions by using an efficient superpixel segmentation algorithm. In the second step, a mean filtering is performed within each region of both the spectral feature image and the spatial feature image to generate the corresponding region-based spectral and spatial features, respectively. In the final step, both the obtained region-based features are combined and incorporated into a probabilistic kernel collaboration classifier by taking advantage of a composite kernel framework. Experimental results on two real hyperspectral images demonstrate the improvement of RCK over the traditional composite kernel framework, as well as its effectiveness as compared to some popular spatial-spectral techniques.
E-commerce Adoption in Argentina and Its Role in SMEs Growth

E-commerce plays a vital role in the success of businesses today. Technology is influencing all aspects of our lives from socializing, online education, e-medical services to online buying. Although, E-commerce has been in existence in developed countries for decades now, developing countries are still in their early stages of adoption. In case of Argentina, a Latin American nation, E-commerce is growing at a rapid rate as the data from Argentinian Chamber of E-commerce reveals. The impact of E-commerce in the country is already profound given its short period of existence. There are several benefits of E-commerce adoption compared to setting up a conventional brick and mortar store, it reduces transaction cost, efficient communication, removes intermediaries, widens target customer market, increases employee productivity. Despite, great importance, there is dearth of scholarly literature on E-commerce and its impact on consumer’s purchasing trend. This paper aims at highlighting the importance of this topic and building scholarly literature which can be used by other researcher as foundation for further research.
A Quantitative Examination of the Relationship Between Perceived Job Satisfaction and Organizational Commitment in Small Business Employees in the Lynchburg Metropolitan Statistical Area

The Lynchburg Metropolitan Statistical Area (MSA) has an average turnover that exceeds the national and regional average. Organizational turnover unfavorably influences productivity and has the potential to adversely affect, not only the Lynchburg MSA, but also the regional, state, and national economy. This quantitative nonexperimental, correlational research examined the relationship between perceived job satisfaction and organizational commitment in the Lynchburg MSA. The results of this research supports earlier research and demonstrated a statistically significant positive relationship existed between perceived job satisfaction and organizational commitment in small business employees in the Lynchburg MSA. The results may serve as beneficial to small business leaders for influencing human resource management processes aimed at increasing retention, reducing turnover, and remaining competitive in both the region and state.
MAP4‐Dependent Regulation of Microtubule Formation Affects Centrosome, Cilia, and Golgi Architecture as a Central Mechanism in Growth Regulation

Numerous genes are involved in human growth regulation. Recently, autosomal‐recessive inherited variants in centrosomal proteins have been identified in Seckel syndrome, primary microcephaly, or microcephalic osteodysplastic primary dwarfism. Common hallmarks of these syndromic forms are severe short stature and microcephaly. In a consanguineous family with two affected children with severe growth retardation and normocephaly, we used homozygosity mapping and next‐generation sequencing to identify a homozygous MAP4 variant. MAP4 is a major protein for microtubule assembly during mitosis. High‐expression levels in the somite boundaries of zebrafish suggested a role in growth and body segment patterning. The identified variant affects binding sites of kinases necessary for dynamic instability of microtubule formation. We found centrosome amplifications in mitotic fibroblast cells in vivo and in vitro. These numeric centrosomal aberrations were also present during interphase resulting in aberrant ciliogenesis. Furthermore, affected cells showed a dysfunction of the microtubule‐dependent assembly of the Golgi apparatus, indicated by a significant lack of compactness of Golgi membranes. These observations demonstrated that MAP4 mutations contribute to the clinical spectrum of centrosomal defects and confirmed the complex role of a centrosomal protein in centrosomal, ciliary, and Golgi regulation associated with severe short stature.
Zantedeschia mild mosaic virus, a new widespread virus in calla lily, detected by ELISA, dot‐blot hybridization and IC‐RT‐PCR

A new potyvirus, Zantedeschia mild mosaic virus (ZaMMV), was recently identified in calla lily ( Zantedeschia spp.) in Taiwan. The sequenced 3 ′ -terminal region indicated a unique amino acid sequence of ZaMMV, the N terminus of the capsid protein (CP), containing 39 glutamine residues before the DAG motif. In order to obtain antiserum for subsequent studies, a recombinant ZaMMV CP without polyglutamine was successfully expressed in Escherichia coli and used as the antigen. The specificity of ZaMMV antiserum was confirmed by immunoblot and ELISA analyses. Three detection methods, ELISA, dot-blot hybridization and immunocapture reverse transcription PCR (IC-RT-PCR), were developed and were able to detect ZaMMV successfully. During 2003‐2004 field surveys, the results demonstrated that ZaMMV, as well as Zantedeschia mosaic virus (ZaMV), are prevalent in calla-growing areas. In contrast, infection by Dasheen mosaic virus (DsMV), the most important virus of aroid plants, decreased dramatically because DsMV-free calla lily seedlings were grown in the field. Accordingly, the detection methods developed in this study will be useful in studying ZaMMV and also in producing ZaMMV-free calla lilies.
Micromechanical Model for the Orthotropic Elastic Constants of Polyetheretherketone Composites Considering the Orientation Distribution of the Hydroxyapatite Whisker Reinforcements

Hydroxyapatite (HA) whisker reinforced polyetheretherketone (PEEK) composites have been investigated as bioactive materials for load-bearing orthopedic implants with tailored mechanical properties governed by the volume fraction, morphology, and preferred orientation of the HA whisker reinforcements. Therefore, the objective of this study was to establish key structure-property relationships and predictive capabilities for the design of HA whisker reinforced PEEK composites and, more generally, discontinuous short fiber-reinforced composite materials. HA whisker reinforced PEEK composites exhibited anisotropic elastic constants due to a preferred orientation of the HA whiskers induced during compression molding. Experimental measurements for both the preferred orientation of HA whiskers and composite elastic constants were greatest in the flow direction during molding (3-axis, C33), followed by the transverse (2-axis, C22) and pressing (1axis, C11) directions. Moreover, experimental measurements for the elastic anisotropy and degree of preferred orientation in the same specimen plane were correlated. A micromechanical model accounted for the preferred orientation of HA whiskers using two-dimensional implementations of the measured orientation distribution function (ODF) and was able to more accurately predict the orthotropic elastic constants compared to common, idealized assumptions of randomly oriented or perfectly aligned reinforcements. Model predictions using the 3-2 plane ODF, and the average of the 3-1 and 3-2 plane ODFs, were in close agreement with the corresponding measured elastic constants, exhibiting less than 5% average absolute error. Model predictions for C11 using the 3-1 plane ODF were less accurate, with greater than 10% error. This study demonstrated the ability to accurately predict differences in orthotropic elastic constants due to changes in the reinforcement orientation distribution, which will aid in the design of HA whisker reinforced PEEK composites and, more generally, discontinuous short fiberreinforced composites. [DOI: 10.1115/1.4005421]
Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F.

Nucleotide excision repair (NER), one of the major cellular DNA repair systems, removes a wide range of lesions in a multi‐enzyme reaction. In man, a NER defect due to a mutation in one of at least 11 distinct genes, can give rise to the inherited repair disorders xeroderma pigmentosum (XP), Cockayne's syndrome or PIBIDS, a photosensitive form of the brittle hair disease trichothiodystrophy. Laboratory‐induced NER‐deficient mutants of cultured rodent cells have been classified into 11 complementation groups (CGs). Some of these have been shown to correspond with human disorders. In cell‐free extracts prepared from rodent CGs 1–5 and 11, but not in a mutant from CG6, we find an impaired repair of damage induced in plasmids by UV light and N‐acetoxy‐acetylaminofluorene. Complementation analysis in vitro of rodent CGs is accomplished by pairwise mixing of mutant extracts. The results show that mutants from groups 2, 3, 5 and XP‐A can complement all other CGs tested. However, selective non‐complementation in vitro was observed in mutual mixtures of groups 1, 4, 11 and XP‐F, suggesting that the complementing activities involved somehow affect each other. Depletion of wild‐type human extracts from ERCC1 protein using specific anti‐ERCC1 antibodies concomitantly removed the correcting activities for groups 4, 11 and XP‐F, but not those for the other CGs. Furthermore, we find that 33 kDa ERCC1 protein sediments as a high mol. wt species of approximately 120 kDa in a native glycerol gradient. (ABSTRACT TRUNCATED AT 250 WORDS)