Miracle-dz/UniFAR-FTUs huggingface dataset:
Newsrooms accommodate data-based news work

Similar to prior cycles of newsroom specialization, news organizations must integrate the expertise of data journalists. Based upon 18 in-depth interviews with data journalism leaders within American newspapers, this study examines how newsrooms are restructuring to accommodate data news work. More specifically, the research identifies four “critical junctures” by which newspapers expand data journalism operations. The interviews establish that expanding a paper’s commitment to data journalism requires reorganizing the newsroom with new layers of structural complexity.
The effects of daily consumption of β-cryptoxanthin-rich tangerines and β-carotene-rich sweet potatoes on vitamin A and carotenoid concentrations in plasma and breast milk of Bangladeshi women with low vitamin A status in a randomized controlled trial.

BACKGROUND The potential of β-cryptoxanthin (CX)-rich foods to form vitamin A (VA) in humans in not well understood. OBJECTIVE We measured the effects of consuming CX- and β-carotene (BC)-rich foods on plasma and breast milk VA and carotenoids in lactating women with low VA status. DESIGN Participants were randomly assigned to 4 groups (n = 34, 34, 34, and 33, respectively) receiving orange-fleshed sweet potatoes (OFSPs) (12 mg BC/d), tangerines (5.3 mg CX/d), white-fleshed sweet potatoes (WFSPs) with a VA supplement (0.5 mg/d), or WFSPs 2 times/d, 6 d/wk for 3 wk. All except the VA group received placebo capsules identical in appearance to VA supplements. Changes in plasma and breast milk VA, BC, and CX were measured. RESULTS Plasma retinol increased in the VA group. Plasma BC in the OFSP group and CX in the tangerine group increased 250% and 830%, respectively; apparent relative absorption in the CX group, considering the amounts consumed, was 4 times that in the BC group. Mean (±SEM) changes in milk VA in the OFSP (0.028 ± 0.074 μmol/L) and tangerine (0.067 ± 0.091 μmol/L) groups did not differ from those in the control (-0.077 ± 0.068 μmol/L) or VA (0.277 ± 0.094 μmol/L) group. Milk CX increased in the tangerine group. CONCLUSIONS VA capsules increased plasma and milk VA concentrations. The greater change in CX concentrations in the tangerine group than in BC concentrations in the OFSP group suggests that CX in tangerines was better absorbed, but both foods failed to increase milk VA concentrations. This trial was registered at clinicaltrials.gov as NCT01420406.
Stability and problems in recovery of fumonisins added to corn-based foods.

Because the natural occurrence of fumonisins is so far known almost exclusively in corn, we have limited our investigations on their stability to corn-based foods. In these studies, distinction must be made between real losses, binding, and any matrix-related method problems. Fumonisins B1 (FB1) and B2 (FB2) were about 40% recovered when heated in corn meal at 190 degrees C, about 20-30% recovered when heated in moist corn meal at 190 degrees C, and completely unstable in corn meal at 220 degrees C. Average recoveries of FB1 and FB2 added to blank heated matrixes were 69-107% in control experiments. Baking corn meal muffins spiked with 2.5 micrograms FB1 and FB2/g corn meal at 220 degrees C also resulted in losses of fumonisins. Little or no fumonisins were recovered from corn bran flour when methanol-water (3 + 1) was used as extraction solvent. However, when methanol-borate buffer (pH 9.2) (3 + 1) was used, recoveries averaged 91 +/- 17 and 84 +/- 9%, respectively, for FB1 and FB2; and natural contamination of the corn bran flour with FB1 and FB2 at levels of 1.9 and 0.95 microgram/g, respectively, was revealed. Comparable recoveries were observed for 1 brand of a corn bran breakfast cereal, but the binding effect was not seen with a second brand, for which methanol-water (3 + 1) alone was a good extraction solvent. Recoveries of FB1 and FB2 from a mixed cereal for babies were only about 50% with either extraction solvent mixture. (ABSTRACT TRUNCATED AT 250 WORDS)
Maximizing Offspring Production While Maintaining Genetic Diversity in Supplemental Breeding Programs of Highly Fecund Managed Species

Abstract: Supplemental breeding is an intensive population management strategy wherein adults are captured from nature and spawned in controlled settings, and the resulting offspring are later released into the wild. To be effective, supplemental breeding programs require crossing strategies that maximize offspring production while maintaining genetic diversity within each supplemental year class. We used computer simulations to assess the efficacy of different mating designs to jointly maximize offspring production and maintain high levels of genetic diversity (as measured by the effective population size) under a variety of biological conditions particularly relevant to species with high fecundity and external fertilization, such as many fishes. We investigated four basic supplemental breeding designs involving either monogamous pairings or complete factorial designs (in which every female is mated to every male and vice versa), each with or without the added stipulation that all breeders contribute equally to the total reproductive output. In general, complete factorial designs that did not equalize parental contributions came closest to the goal of maximizing offspring production while still maintaining relatively large effective population sizes. Next, we estimated the effective population size of 10 different supplemental year classes within the breeding program of the robust redhorse (Moxostoma robustum). Two year classes failed to produce progeny, whereas successful year classes used partial factorial designs to realize effective sizes ranging from 2 to 26 individuals. On average, a complete factorial design could increase the effective size of each robust redhorse supplemental year class by 19%.
Antecedents of Cultural Intelligence Among American Hospitality Students: Moderating Effect of Ethnocentrism

ABSTRACT As interactions and markets become increasingly global, hospitality firms must retain culturally-intelligent managers and hospitality education must nurture its students so they are qualified to meet this demand. This study examines the relationship between the cultural intelligence (CQ) of American hospitality students and its possible antecedents: cross-cultural academic training, foreign language skills, daily intercultural social contact, and international travel. Using hierarchical regression analysis of data from 938 American college students enrolled in hospitality programs in the United States, our study demonstrated that these variables generally predict CQ with a few exceptions. Results of multi-group analysis further showed that student ethnocentrism moderates the relationships between the antecedents and CQ. Theoretical and managerial implications of the results and directions for future research are discussed.
Isolation and culture of embryonic stem-like cells from pig nuclear transfer blastocysts of different days

Summary This study was conducted to establish pig embryonic stem (ES)-like cell lines from nuclear transfer blastocysts. A green fluorescent protein (GFP)-expressing cell line was used as the source of donor cells injected into the enucleated oocytes. Blastocysts were collected at D5 (the fifth day), D7 (the seventh day) and D9 (the ninth day). Differential staining was used to assay the viability and development of blastocysts from the 3 days. The number of inner cell mass (ICM) cells increased from 1.83 ± 0.8 (D5) to 5.37 ± 1.2 (D7) to 7.56 ± 1.5 (D9). The expression profiles of embryonic stem (ES) cell factors (OCT4, SOX2, KLF4 and c-MYC) correlated best with the undifferentiated ES state and were identified by qPCR. The expression of the four factors was increased from D5 to D7, whereas the expression decreased from D7 to D9. We tried to isolate ES-like cells from these embryos. However, ES-like cells from the D7 blastocysts grew slowly and expressed alkaline phosphatase. The cells from the D9 blastocysts grew rapidly but did not express alkaline phosphatase. ES-like cells were not isolated from the D5 blastocysts. These results show that the cells from the D7 embryos are pluripotent but grow slowly. The cells from the D9 embryos grow rapidly but start to lose pluripotency.
All optoelectronic generation and detection of millimeter-wave signals

We demonstrate all-optoelectronic 1.55-/spl mu/m-based approaches to radiate and receive continuous millimeter-wave signals. 60-GHz millimeter-wave signals with power of more than 10 dBm, generated with an actively mode-locked laser diode and a uni-travelling-carrier photodiode, are emitted from an antenna and are electro-optically detected with a CdTe electric-field sensor with high sensitivity.
Extracellular calcium-sensing receptor is critical in hypoxic pulmonary vasoconstriction.

AIMS The initiation of hypoxic pulmonary vasoconstriction (HPV) involves an increase in cytosolic calcium ([Ca(2+)](i)) in pulmonary artery (PA) smooth muscle cells (PASMCs). Both the processes depend on extracellular Ca(2+). Extracellular Ca(2+) can be sensed by extracellular calcium-sensing receptor (CaSR). This study aims at determining whether CaSR is pivotal in the initiation of HPV. RESULTS Experiments were performed in cultured PASMCs, isolated PAs, and rats including CaSR knockdown preparations. Both hypoxia and H(2)O(2) equivalent to the level achieved by hypoxia increased [Ca(2+)](i) in an extracellular Ca(2+)-dependent manner in PASMCs, and this was inhibited by CaSR knockdown or its negative allosteric modulator, Calhex231. Hypoxia-increased H(2)O(2) generation was diminished by mitochondria depletion. Mitochondria depletion abolished hypoxia-induced [Ca(2+)](i) increase (HICI), which was reversed by H(2)O(2) repletion. CaSR knockdown or Calhex231, however, prevented the reversible effect of H(2)O(2). HICI was abolished by catalase-polyethylene glycol (PEG-Catalase), not superoxide dismutase-polyethylene glycol (PEG-SOD) pretreatment, attenuated by ryanodine receptor3-knockdown or inhibition of store-operated Ca(2+) entry. HPV in vitro and in vivo was inhibited by Calhex231 and by CaSR knockdown. INNOVATION A novel mechanism underlying HPV is revealed by the role of CaSR in orchestrating reactive oxygen species and [Ca(2+)](i) signaling. CONCLUSIONS The activation of mitochondrial H(2)O(2)-sensitized CaSR by extracellular Ca(2+) mediates HICI in PASMCs and, thus, initiates HPV.
DNA‐based immunotherapy: potential for treatment of chronic viral hepatitis?

Persistent HBV and HCV infection represent major causes of chronic liver disease with a high risk of progression to liver cirrhosis and hepatocellular carcinoma (HCC). Conventional protein‐based vaccines are highly efficacious in preventing HBV infection; whereas in therapeutic settings with chronically infected patients, results have been disappointing. Prophylactic vaccination against HCV infection has not yet been achieved due to many impediments including frequent spontaneous mutations of the virus with escape from immune system control. Using animal models it has been demonstrated that DNA‐based immunisation strategies may overcome this problem because of their potential to induce immunity against multiple viral epitopes. DNA‐based vaccines mimic the effect of live attenuated viral vaccines, eliciting cell mediated immunity in addition to inducing humoral responses. Efficacy may further be improved by addition of DNA encoding immunomodulatory cytokines and more recently, direct genetic modulation of antigen‐presenting cells, such as dendritic cells (DC), has been shown to increase antigen‐specific immune responses. This review focuses on immunological aspects of chronic HBV and HCV infection and on the potential of DNA‐ and DC‐based vaccines for the treatment of chronic viral hepatitis. Copyright © 2002 John Wiley & Sons, Ltd.
A Low-Noise CMOS Distributed Amplifier for Ultra-Wide-Band Applications

To employ the distributed amplification technique for the design of ultra-wide-band low-noise amplifiers, the poor noise performance of the conventional distributed amplifiers (DAs) needs to be improved. In this work, the terminating resistor of the gate transmission line, a main contributor to the overall DA's noise figure, is replaced with a resistive-inductive network. The proposed terminating network creates an intentional mismatch to reduce the noise contribution of the terminating network. The degraded input matching at low frequencies can be tolerated for ultra-wide-band applications as they need to operate above 3 GHz. Implemented in a 0.13 mum CMOS process, the proposed DA achieves a flat gain of 12 dB with an average noise figure of 3.3 dB over the 3- to 9.4-GHz band, the best reported noise performance for a CMOS DA in the literature. The amplifier dissipates 30 mW from two 0.6-V and 1-V dc power supplies.
Time of arrival based localization of UWB transmitters buried in lossy dielectric media

An algorithm for subsurface localization of UWB transmitters in homogeneous dielectric media is presented. In combination with surface estimation algorithms for UWB pulse radars it allows localization behind arbitrarily shaped medium surfaces. We propose a localization system operating in the FCC UWB frequency range from 3.1 to 10.6 GHz consisting of a transmitter optimized for radiation in high permittivity media and of external radar sensors. The sensors scan the dielectric surface and also measure the time of arrival (ToA) of the signal transmitted from inside of the medium. The transmitter location is estimated by combining the measured ToA data with the knowledge about shape and position of the medium. Therefore a method to calculate wavefront refraction on the medium boundary based on the Huygens-Fresnel principle is derived. The performance of the proposed localization method is verified using electro-magnetic field simulations and measurements. The measurements have been performed with the transmitter placed in high permittivity tissue-mimicking liquid. The localization results are compared with the manually measured transmitter position showing a good agreement.
Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice.

BACKGROUND Combretastatin A-4 (CA-4) and its analogs are potent inhibitors of tubulin polymerization and display strong inhibitory activity on both solid tumor and tumor cell growth. Since natural CA-4 is difficult to synthesize and also isomerizes to an inactive form quite readily, a recently reported new 3,4-diarylfuran-2-one-based series of CA-4 analogs was investigated, in the hope of bypassing some of these difficulties. These analogs appear to offer a valuable tool for CA-4 research because of their extremely facile synthesis from readily available starting materials. MATERIALS AND METHODS The CA-4 analogs were evaluated by MTT assay, cell cycle analysis, tubulin polymerization and tumor-inhibiting experiments. RESULTS Various benzene ring substitutions on the furan-2-one skeleton (analogs to the two aromatic rings on the CA-4 styrene skeleton) quickly demonstrated that the structure-activity relationships are quite similar to previously synthesized CA-4 analogs. The most interesting analog appears to be an anilino compound (NV-5-9) which was also quite soluble. Analog NV-5-9 was remarkably potent in all tested tumor cell lines and could strongly inhibit tubulin polymerization at doses as low as 1 mM. Further experiments with tumor-bearing mice indicated that NV-5-9 and other potent analogs (NV-4-82 and NV-4-86) were effective in treating human prostate PC-3 and SCLC NCI-H69 tumors at well below an oral MTD dose of around 200 mg/kg body weight. This suggests some bioavailability by this route. CONCLUSION These data strongly support that NV-5-9 is extremely potent, readily synthesizable and apparently suitable for in vivo studies employing transplanted tumors.
Characterization of a rat model of bortezomib‐induced painful neuropathy

Bortezomib (Velcade®) is a breakthrough treatment for multiple myeloma, significantly improving patient survival. However, its use is limited by painful neuropathy often resulting in dose reduction/cessation of first‐line treatment due to lack of treatment. The aim of this study was to characterize a clinically relevant rat model of bortezomib‐induced painful neuropathy, using established evoked measures and novel ethological techniques, to aid drug discovery.
Skip entry trajectory tracking with consideration of the rotation of the Earth

This paper mainly considers a lunar return skip entry trajectory tracking problem. The flight range and duration time of lunar return entry are rather long, so the effect of the rotation of the Earth should be considered. The guidance dynamics have more nonlinearities and couplings considering the rotation of the Earth, which make the trajectory tracking more difficult. In the existing literature, the rotation of the Earth is usually ignored in the guidance design and characteristics of dynamics and closed-loop system lack theoretical analysis. Considering the above problems, the longitudinal reentry dynamics are analyzed in detail first. The relative degree of the motion equations is calculated as 2 while the states of the motion are chosen as the drag, the first derivative of drag and velocity, with drag as the output and bank angle as the input and the map from original states to the new ones is proved as a diffeomorphism. The velocity equation is proved as bounded-input-bounded-state stable. Then, ADRC(Active Disturbance Rejection Control) method is adopted to design the guidance, and the principles of choosing control parameters are also given. Moreover, the drag tracking error boundedness is proved in theory. The method proposed without the need of linearization or simplification of the dynamics, has higher precision, wider scope of application and reduced conservation. The dynamics properties and closed-loop analysis presented in this paper could provide a reference to the hypersonic vehicle reentry guidance, lunar or Mars reentry guidance or feedback linearization control design. Finally, the effectiveness of the guidance is illustrated through simulation.
Uncemented STAR Total Ankle Prostheses: Three to Eight-Year Follow-up of Fifty-one Consecutive Ankles

Background: The feasibility of replacing the ankle joint has been a matter of speculation for a long time. In recent years, the designs of ankle prostheses have been improved, and three designs, all used without bone cement, currently dominate the market. However, documentation of the clinical results of the use of these prostheses is sparse. We reviewed the intermediate-term results of fifty-one consecutive Scandinavian Total Ankle Replacements (STAR). Methods: Between 1993 and 1999, fifty-one consecutive ankles were replaced with an uncemented, hydroxyapatite-coated STAR total ankle prosthesis. Clinical examination for the present study was performed by one surgeon who had not taken part in the operations. Standardized radiographs were used. Complications and failures were recorded, and patient satisfaction and functional outcome scores were determined for all patients with an unrevised implant. Results: Twelve ankles had to be revised. Seven were revised because of loosening of at least one of the components; two, because of fracture of the meniscus; and three, for other reasons. A component was exchanged in seven of the twelve revisions, whereas the ankle was successfully fused in the other five. An additional eight ankles had radiographic signs of loosening. The thirty-nine unrevised ankles (thirty-seven patients) were examined after thirty-six to ninety-seven months (median, fifty-two months). The patient was satisfied with the result after thirty-one of the ankle replacements, somewhat satisfied after two, and not satisfied after six. The median Kofoed score increased from 39 points before the surgery to 70 points at the time of the follow-up examination. A median follow-up score of 74 points was recorded when the system described by Mazur et al. and the AOFAS (American Orthopaedic Foot and Ankle Society) system were used. The median range of motion was approximately the same preoperatively and postoperatively. The estimated five-year survival rate, with revision for any reason as the end point, was 0.70. When radiographic loosening of either component was used as the end point, the estimated five-year radiographic survival rate was significantly better for the last thirty-one ankles treated in the series (p = 0.032). Conclusions: Total ankle replacement may be a realistic alternative to arthrodesis, provided that the components are correctly positioned and are of the correct size. However, the risks of loosening and failure are still higher than are such risks after total hip or total knee replacement. Level of Evidence: Therapeutic study, Level IV (case series [no, or historical, control group]). See Instructions to Authors for a complete description of levels of evidence.
Effects of nipradilol on myocardial ischaemia produced by coronary stenosis in dogs

1 Effects of nipradilol which is a new β‐adrenoceptor blocking agent endowed with nitroglycerin‐like vasodilator actions, its denitrated derivative (denitro nipradilol) and propranolol on abnormalities of regional myocardial shortening produced by partial occlusion of the left circumflex coronary artery (LCX) were studied in anaesthetized open‐chest dogs. 2 In the presence of LCX stenosis, nipradilol (0.1 mg kg−1, i.v.) produced marked decreases in heart rate and LV dP/dt without a significant increase in left ventricular end‐diastolic pressure (LVEDP). It improved impaired myocardial segment shortening and restored normal cardiac lactate metabolism. 3 Denitro nipradilol (0.2 mg kg−1 i.v.) and propranolol (0.2 mg kg−1 i.v.) both caused similar haemodynamic changes to nipradilol but also produced a significant increase in LVEDP. However, improvement by these two agents of regional dysfunction in the ischaemic myocardium was comparable to those seen with nipradilol. 4 All three agents markedly inhibited isoprenaline‐induced tachycardia, but vehicle did not. 5 Atrial pacing abolished the beneficial effect of nipradilol on myocardial shortening in the ischaemic region without affecting other haemodynamic parameters. 6 These results indicate that nipradilol alleviates acute myocardial ischaemia produced by coronary stenosis with similar efficacy to denitro nipradilol and propranolol suggesting, that a major part of the beneficial effect of nipradilol may be attributable to its β‐adrenoceptor blocking action.
Effect of mitochondrial clustering on O2 supply in hepatocytes.

Isolated rat hepatocytes were treated with digitonin to selectively disrupt the plasma membrane and allow study of the O2 dependence of mitochondria within the cell cytoskeleton, but without cytosol. Half-maximal oxidation of cytochrome c occurred at 2.0 microM O2 in treated cells incubated under State 3 conditions, whereas in intact cells it was 6.0 microM and in isolated mitochondria (State 3) 0.69 microM. the intermediate value for treated cells indicates that both the geometry of mitochondrial packing and the intracellular diffusion coefficient are important in determining intracellular mitochondrial O2 dependence. Analysis of intracellular diffusion, assuming that the mitochondrial clustering increases the effective mitochondrial radius, indicates that an intracellular diffusion coefficient of between 10(-6) and 4 X 10(-6) cm2 . s-1 and an effective mitochondrial radius of approximately 2 micron would account for the observed intracellular O2 dependence of mitochondrial function.