Miracle-dz/UniFAR-FTUs huggingface dataset:
Maddi Hasarlı Trafik Kazaları İçin Sinirsel-Bulanık Ağ Tabanlı Bir Kusur Tespit Modeli

Maddi hasarli bir trafik kazasi meydana geldiginde, kazaya dahil kisilerin tumu, yetkili ve gorevli kisinin gelmesine luzum gormezlerse, bunu aralarinda yazili olarak saptamak sureti ile kaza yerinden ayrilabilirler. Kazaya dahil kisiler kendi aralarinda anlasamaz ise taraflarin kayiplarinin tazmin edilmesi icin kusur oranlarinin belirlenmesinin onemi buyuktur. Son yillarda trafik kazalariyla ilgili hazirlanan bilirkisi raporlari incelendiginde kusur oranlarinin kabaca belirlendigi, ayrintili kaza analizlerinin yapilmadigi gorulmektedir. Bu calismada, karsilikli anlasma yoluyla cozulemeyen, hakkinda dava acilip bilirkisi gorusune ihtiyac duyulan maddi hasarli trafik kazalarinda hassas kusur tespiti yapacak ANFIS (Adaptive Network based Fuzzy Inference System, Adaptif Ag Tabanli Bulanik Mantik Cikarim Sistemi) tabanli bir model gelistirilmistir. Turkiye Istatistik Kurumu'nun konuyla ilgili 2016 yilina kadar yapilan istatistiklerine gore, en sik gorulen kaza tipleri goz onune alinarak dort adet temel kaza senaryosu benzetim yoluyla yeniden canlandirilmistir. Her senaryo icin 500 adet veri uretilmis, 10 katli capraz dogrulama ile bu verilerin %90’i egitim %10’u ise test icin kullanilmis olup alinan sonuclar, onceki calismalarda elde edilen tahmin sonuclari ile karsilastirilmistir. Calismanin sonucunda ANFIS tabanli kusur tahmin modelinin, kazaya yonelik cesitli parametreleri degerlendirerek cok dusuk hata oranlari ile taraflara ait kusurlari belirleyebildigi gorulmustur.
Dentin Extracellular Matrix (ECM) Proteins: Comparison to Bone ECM and Contribution to Dynamics of Dentinogenesis

Dentinogenesis involves the initial odontoblastic synthesis of a collagen-rich extracellular matrix (ECM) and predentin that is converted to dentin when the collagen fibrils become mineralized. Since the width of predentin is rather uniform, we postulate that extracellular events regulate dentinogenesis. Similarly, osteogenesis involves an initial unmineralized osteoid that is mineralized and converted to bone. To gain insights into these two processes, we compared ECM proteins in bone with those in dentin, focusing upon the sialic acid (SA)-rich proteins. We observed qualitative similarities between the SA-rich proteins, but distinct differences in the amounts of osteopontin (OPN) and dentin sialoprotein (DSP). OPN, a predominant protein in bone, was found in much smaller amounts in dentin. Conversely, DSP was abundant in dentin ECM, but found sparingly in bone. Molecular cloning experiments indicate that coding sequences for DSP and dentin phosphoprotein (DPP) are found on the same mRNA. We believe that the initial form of the precursor protein DSPP is inactive in influencing the mineralization process and that it must be activated by cleavage of peptide bonds in conserved regions. Thus, unknown proteinases would act on DSPP, possibly at the mineralization front, and liberate active DPP, which plays an initiation and regulatory role in the formation of apatite crystals. This post-translational processing reaction would represent an important control point in dentinogenesis. Recently, we identified uncleaved DSPP in dentin extracts, which should allow us to test portions of our hypothesis.
Evaluation of LoRa and LoRaWAN for wireless sensor networks

LoRa is a new ISM band wireless technology designed for low power, unlicensed, Long Range operation. LoRaWAN is a Wide Area Network protocol that incorporates the LoRa wireless into a networked infrastructure. The indoor and outdoor performance of these technologies, the physical layer wireless and multi-gateway wide area network, was evaluated across the central business district (CBD) of Glasgow city (Scotland). The results indicated that this technology can be a reliable link for low cost remote sensing applications.
Physical Association of Saccharomyces cerevisiae Polo-like Kinase Cdc5 with Chromosomal Cohesin Facilitates DNA Damage Response*

At the onset of anaphase, a protease called separase breaks the link between sister chromatids by cleaving the cohesin subunit Scc1. This irreversible step in the cell cycle is promoted by degradation of the separase inhibitor, securin, and polo-like kinase (Plk) 1-dependent phosphorylation of the Scc1 subunit. Plk could recognize substrates through interaction between its phosphopeptide interaction domain, the polo-box domain, and a phosphorylated priming site in the substrate, which has been generated by a priming kinase beforehand. However, the physiological relevance of this targeting mechanism remains to be addressed for many of the Plk1 substrates. Here, we show that budding yeast Plk1, Cdc5, is pre-deposited onto cohesin engaged in cohesion on chromosome arms in G2/M phase cells. The Cdc5-cohesin association is mediated by direct interaction between the polo-box domain of Cdc5 and Scc1 phosphorylated at multiple sites in its middle region. Alanine substitutions of the possible priming phosphorylation sites (scc1-15A) impair Cdc5 association with chromosomal cohesin, but they make only a moderate impact on mitotic cell growth even in securin-deleted cells (pds1Δ), where Scc1 phosphorylation by Cdc5 is indispensable. The same scc1-15A pds1Δ double mutant, however, exhibits marked sensitivity to the DNA-damaging agent phleomycin, suggesting that the priming phosphorylation of Scc1 poses an additional layer of regulation that enables yeast cells to adapt to genotoxic environments.
The node selection of satellite attitude control system based on sensitivity function in Bayesian network

In order to improve efficiency and save limited storage space for on-orbit fault diagnosis system, the node selection problem of satellite attitude control system based on the sensitivity function in Bayesian Network is investigated. First, the Bayesian Network model of the satellite attitude control system is established based on expert experience and historical fault data, so that to reduce the complexity and uncertainty of the system. Then, through analyzing the importance of each node, a node selection algorithm is proposed through using Bayesian sensitivity function, which can greatly improve the reliability and fault diagnosis performance of the whole system. Finally, numerical computation results show that the proposed algorithm is efficient and has the potential to be used in practice.
Affects, Actions and Passions in Spinoza

Nowadays there is a great enthusiasm for the Spinozan conception of the union of mind and body among modern researchers, such as Damasio. The fact that the Spinozan model has become very relevant is an opportunity to reflect on the impact and value of these references to Spinoza, which historians of philosophy eye with caution because they are all too often based on second-hand knowledge, and frequently distort the philosopher's thought. That is why it is crucial to reexamine the question of the mind-body relationship and its affective modalities in Spinoza from a philosophical angle and identify a model for interpreting it that is capable of informing contemporary debates.
Vitalism Now – A Problematic

This paper considers whether and how ‘vitalism’ might be considered relevant as a concept today; whether its relevance should be expressed in terms of disciplinary demarcations between the life sciences and the natural sciences; and whether there is a fundamental incompatibility between a ‘vitalism of process’ and a ‘vitalism as pathos’. I argue that the relevance of vitalism as an epistemological and ontological problem concerning the categorical distinction between living and non-living beings must be contextualized historically, and referred exclusively to the epistemic horizon defined by classical physics. In contrast to this, drawing on the philosophies of Canguilhem, Whitehead, and Atlan, I propose an appreciation of the contemporary relevance of vitalism premised on the pathic and indeterminate character of nature as a whole. From this perspective vitalism expresses a politically significant ethos concerning the relationship between life, knowledge, problems and their solutions.
New correlation-based scheme for image authentication

With a rapid growth of digital image distributions, there has been a corresponding surge in digital counterfeiting of confidential documents. Secrecy of documents and copyright protection techniques have been introduced in an attempt to address this growing concern. Recently, digital image watermarks have been proposed to copyright image data. In this paper a new Digital Image Authentication System is proposed. This system is designed to detect any small change made in an image, including any alteration in pixel values or image size. It uses a watermarking scheme, which is based on correlation coefficient statistics, the Secure Hash Algorithm (SHA-1), and the Elliptic Curve Digital Signature algorithm (ECDSA). The generated signature is then embedded in the image spatial domain. Experimental results show that this system has the ability to accurately authenticate images, while preserving their quality.
A Hybrid Metaheuristic Approach to Solve the Vehicle Routing Problem with Time Windows

This paper addresses the Capacitated Vehicle Routing Problem with Time Windows, with constraints related to the vehicle capacity and time windows for customer service. To solve this problem two different metaheuristics are used: Tabu Search and Genetic Algorithms. Based on these techniques a hybrid algorithm is developed. The main goal is the development of a Hybrid Algorithm focused on the Vehicle Routing Problem which uses the intensification power of the Tabu Search and the diversification power of the Genetic Algorithms, in order to obtain good quality solutions without compromising the computational time. In the experiments are combined policies of diversification and intensification in Tabu Search and Genetic Algorithm to verify the efficiency and robustness of the proposed hybrid algorithm. Finally, the results are compared with the best heuristic and exact methods results found in the literature. The Hybrid Algorithm here proposed shows efficiency and robustness, with several optimal solutions achieved.
Cullin 3 mediates SRC-3 ubiquitination and degradation to control the retinoic acid response

SRC-3 is an important coactivator of nuclear receptors including the retinoic acid (RA) receptor α. Most of SRC-3 functions are facilitated by changes in the posttranslational code of the protein that involves mainly phosphorylation and ubiquitination. We recently reported that SRC-3 is degraded by the proteasome in response to RA. Here, by using an RNAi E3-ubiquitin ligase entry screen, we identified CUL-3 and RBX1 as components of the E3 ubiquitin ligase involved in the RA-induced ubiquitination and subsequent degradation of SRC-3. We also show that the RA-induced ubiquitination of SRC-3 depends on its prior phosphorylation at serine 860 that promotes binding of the CUL-3–based E3 ligase in the nucleus. Finally, phosphorylation, ubiquitination, and degradation of SRC-3 cooperate to control the dynamics of transcription. In all, this process participates to the antiproliferative effect of RA.
Multidimensional aspects of pain in myotonic dystrophies

To analyze the frequency and intensity of pain and its association with different characteristics of patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2), 52 adult genetically confirmed DM1 and 44 DM2 patients completed the Brief Pain Inventory questionnaire (BPI). Frequency and average intensity of pain on numerical rating scale (0-10) were similar in DM1 and DM2 (88% vs. 86% and 4.6 ± 2.3 vs. 4.2 ± 1.8, respectively, p > 0.05). In DM1, average pain intensity showed strong association with longer duration of disease and inverse relation with cognition. In DM2, average pain intensity showed association with female gender and emotions. Average pain intensity correlated with Individualized Neuromuscular Quality of Life (INQoL) total score in both DM1 (rho = +0.30, p < 0.05) and DM2 patients (rho = +0.61, p < 0.01). In conclusion, the majority of DM1 and DM2 patients have mild to moderate pain. Our results open new opportunities for behavioral and cognitive interventions.
Quality of life of patients with Duchenne muscular dystrophy: from adolescence to young men

Abstract Purpose: This study investigated quality of life (QOL) in adolescent and young men with Duchenne muscular dystrophy (DMD). Methods: Health-related QOL and global QOL were assessed with the Short Form 36 (SF-36) and World Health Organization Quality of Life-BREF (WHOQOL-BREF). Associations between functional status and QOL were assessed. Results: All domains of the SF-36 were below Taiwan norms (effect size: −14.2 to −0.5), especially Physical Function, Role Physical, and Social Function. Three of the four domains of the WHOQOL-BREF were below Taiwan norms (effect size: −2.0 to −0.7). The Physical Function of the SF-36 was moderately correlated with functional status (mobility, basic activities of daily living, and arm function). The Social Function of the SF-36 and Social Relationships of the WHOQOL-BREF were also moderately correlated with functional status (impairment, basic activities of daily living, and arm function). Conclusion: The adolescent and young men with DMD had poor health-related and global QOL. Poor QOL was related to both physical condition and social health. We suggest that rehabilitation programs focus on using assistive devices to facilitate arm function and encouraging participation in social activities to improve the QOL of patients with DMD. Implications for rehabilitation Duchenne muscular dystrophy (DMD) is a progressive muscle weakness disease that not only impacts physical health but also leads to poor quality of life in many domains. A valuable rehabilitation goal for patients with DMD is to encourage participation in social activities. Medical care and educational programs should plan a formal transition processes for patients with DMD from pediatric to adult care to maximum their quality of life. Arm function is associated with many domains of global quality of life, so a key element in improving quality of life may be to improve arm function.
Elevated amylase is related to the development of respiratory failure in organophosphate poisoning

1 A retrospective study of organophosphate(OP) poison ing in the intensive care unit was performed to analyze the incidence of respiratory failure. 2 The patients were treated initially with gastrointest inal decontamination including gastric lavage and the administration of activated charcoal with cathartic. Further management included intravenous pralidoxim and atropine and ventilatory support. 3 Of the 32 OP poisoning patients, 16 patients developed respiratory failure and received ventilatory support. 4 An increase in plasma amylase above the normal range on the day of admission was related to the development of respiratory failure. 5 In OP poisoning, the elevation of amylase level was predictive of the subsequent respiratory failure.
Roles of the TREX complex in nuclear export of mRNA

Recent studies have established that nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3’-end formation and even translation. It is suggested that the manner in which individual mRNAs are transcribed and processed in the nucleus affects nuclear export and eventually their cytoplasmic fates, thus such inter-dependence could be especially important for the efficient expression of newly transcribed mRNAs, which are encoded on genes activated by different stimuli including various environmental stresses and developmental cues. Here we describe recently uncovered molecular mechanisms of the nuclear export of mRNA, in which the TREX (TRanscription-EXport) complex plays important roles of functionally connecting transcription, mRNA packaging and nuclear export.
Cross-site differences in foraging behavior of white-faced capuchins (Cebus capucinus).

Researchers have identified a variety of cross-site differences in the foraging behavior of free-ranging great apes, most notably among chimpanzees (Pan troglodytes) and more recently orangutans (Pongo pygmaeus), that are not due to obvious genetic or ecological differences. These differences are often referred to as "traditions. " What is not known is whether this high level of interpopulation variation in behavior is limited to hominoids. In this study, we use long-term data from three Costa Rican field sites that are geographically close and similar ecologically to identify potential foraging traditions in white-faced capuchins (Cebus capucinus). Foraging traditions are predicted in Cebus because of many behavioral and morphological convergences between this genus and the great apes. The processing techniques used for the same food species were compared across sites, and all differences found were classified as present, habitual, or customary. Proximity data were also analyzed to determine if social learning mechanisms could explain variation in foraging behavior. Of the 61 foods compared, we found that 20 of them are processed differently by capuchins across sites. The differences involve pound, rub, tap, "fulcrum," "leaf-wrap," and "army ant following. " For most of the differences with enough data to analyze, the average proximity score of the "matched" dyads (two individuals within a group who shared a "different" processing technique) was statistically higher than the average proximity score of the remaining "unmatched" dyads.
Hybrid RAID: A Solution for Enhancing the Reliability of SSD-Based RAIDs

The failure probability in SSDs increases when the number of Program/Erase (P/E) cycles increases. Traditionally, a group of SSDs are protected with parity disks, called SSD-based RAID. It has been shown that the reliability of RAIDs depends on the distribution of parities among SSDs. There are two main policies to distribute parities among SSDs in RAIDs, i.e., evenly and unevenly. By distributing parities evenly, all SSDs would wear out with the same rate, causing simultaneous failures of SSDs. By distributing parities unevenly, one of the SSDs in RAID may fail much earlier than the others. Both these two drawbacks, i.e., the simultaneous failures of SSDs and the rapid first failure of one SSD, reduce the reliability of SSD-based RAIDs. This paper proposes a Hybrid RAID, called Hy-RAID, as a solution to mitigate the above-mentioned drawbacks of the pure evenly- and unevenly-based RAIDs. Hy-RAID changes the policy of parity distribution when the number of P/E cycles of SSDs reaches to a predefined limit. To evaluate the reliability of Hy-RAID, two new quantitative metrics are proposed. The results show that Hy-RAID enhances reliability as compared with traditional RAIDs by omitting the simultaneous disk failures and postponing the first disk failure.
Direct or indirect association in a complex disease: the role of SLC22A4 and SLC22A5 functional variants in Crohn disease

A common haplotype spanning 250 kb on chromosome 5q31 is strongly associated with Crohn disease (CD). Recently, two functional variants within the SLC22A4 and SLC22A5 genes at this locus (IBD5), L503F (c.1507C>T) and G‐207C (c.‐207G>C), have been proposed to contribute directly to susceptibility to CD. However, extensive linkage disequilibrium at the IBD5 locus has complicated efforts to distinguish causal variants from association of the general risk haplotype. We genotyped the SLC22A4 and SLC22A5 variants and other polymorphisms across the risk haplotype in four populations of European origin, and applied regression‐based haplotype analysis to over 1,200 fully genotyped case–control pairs, modeling case/control status on the presence of one or more SNPs to test for conditional association and to identify risk haplotypes. We found highly significant association of SNPs at the IBD5 locus with Crohn disease in all populations tested. However, the frequencies of L503F and G‐207C in individuals who did not carry the general IBD5 risk haplotype were not significantly different in cases and controls, with associated disease odds ratios (ORs) of 0.90 (95% CI, 0.57–1.40) and 0.90 (95% CI, 0.65–1.23), respectively. Haplotype analysis showed that addition of the SLC22A4 and SLC22A5 variants to a null model that included the background risk haplotype did not significantly improve the model fit. In addition to the common risk haplotype, several rare haplotypes had an increased frequency in cases compared to controls. This study suggests that the molecular basis for Crohn disease susceptibility at the IBD5 locus remains to be defined, and highlights the challenge of the identification of causal variants in a complex disease in regions of extensive linkage disequilibrium. Hum Mutat 27(8), 778‐785, 2006. Published 2006 Wiley‐Liss, Inc.
Risk factors for suboptimal infant breastfeeding behavior, delayed onset of lactation, and excess neonatal weight loss.

OBJECTIVE Some mothers have difficulty initiating lactation even when highly motivated to breastfeed. The purpose of this study was to determine the incidence of and risk factors for suboptimal infant breastfeeding behavior (SIBB), delayed onset of lactation, and excess neonatal weight loss among mother-infant pairs in a population with high educational levels and motivation to breastfeed. METHODS All mothers residing in Davis, California, who gave birth to a healthy, single, term infant at 1 of 5 area hospitals during the 10-month recruitment period in 1999 were invited to participate if they were willing to attempt to breastfeed exclusively for at least 1 month. Lactation guidance was provided and data were collected in the hospital (day 0) and on days 3, 5, 7, and 14. Infant breastfeeding behavior was evaluated by trained lactation consultants using the Infant Breastfeeding Assessment Tool. Onset of lactation was defined based on maternal report of changes in breast fullness. Infant weight loss was considered excessive if it was >or=10% of birth weight by day 3. RESULTS Of the 328 eligible mothers, 280 (85%) participated in the study. The prevalence of SIBB was 49% on day 0, 22% on day 3, and 14% on day 7. SIBB was significantly associated with primiparity (days 0 and 3), cesarean section (in multiparas, day 0), flat or inverted nipples, infant status at birth (days 0 and 3), use of nonbreast milk fluids in the first 48 hours (days 3 and 7), pacifier use (day 3), stage II labor >1 hour (day 7), maternal body mass index >27 kg/m(2) (day 7) and birth weight <3600 g (day 7). Delayed onset of lactation (>72 hours) occurred in 22% of women and was associated with primiparity, cesarean section, stage II labor >1 hour, maternal body mass index >27 kg/m(2), flat or inverted nipples, and birth weight >3600 g (in primiparas). Excess weight loss occurred in 12% of infants and was associated with primiparity, long duration of labor, use of labor medications (in multiparas), and infant status at birth. The risk of excess infant weight loss was 7.1 times greater if the mother had delayed onset of lactation, and 2.6 times greater if the infant had SIBB on day 0. CONCLUSIONS Early lactation success is strongly influenced by parity, but may also be affected by potentially modifiable factors such as delivery mode, duration of labor, labor medications, use of nonbreast milk fluids and/or pacifiers, and maternal overweight. All breastfeeding mother-infant pairs should be evaluated at 72 to 96 hours' postpartum.