Miracle-dz/UniFAR-FTUs huggingface dataset:
The course of social cognitive and metacognitive ability in depression: Deficit are only partially normalized after full remission of first episode major depression.

OBJECTIVES Research has suggested that patients suffering from major depressive disorder (MDD) experience deficits in the related domains of social cognition and metacognition. Most research has focused on detecting deficits among persons who are acutely symptomatic. Thus, little is known about whether these deficits persist after symptoms have remitted. As a first, this study investigated social cognitive and metacognitive deficits in patients with MDD in the acute and remitted state. DESIGN Longitudinal case-control. METHODS Forty-four drug-naïve depressed patients and an equal number of matched healthy controls were assessed in multiple domains of social cognition including theory of mind, social perception, and metacognition. Additionally, a comprehensive neurocognitive (non-social) test battery was utilized. Following baseline assessment, patients were enrolled in an outpatient treatment programme. Patients reaching remission within 6 months (n = 29) were reassessed 6 months post-remission. Included for analysis were only patients who followed a course of remission (n = 29) and their paired healthy controls (n = 29). RESULTS Analyses of variance revealed that remitted patients performed significantly better at retest than at baseline on nearly all measures. These effects withstood adjusting for test-retest effects. Moreover, remitted patients performed up to level of healthy controls on some but not all social cognitive tasks and metacognition at retest. CONCLUSIONS Overall, results suggests that social cognitive and metacognitive ability may improve with symptom remission in major depression although it may not reach a level equal to persons who have never experienced depression. PRACTITIONER POINTS Many with first-episode depression experience deficits in social cognition. When first-episode depression remits, social cognition may improve. After remission, first-episode depressed patients may still experience deficits in social cognition. We have yet to determine whether social cognitive deficits existed prior to the onset of depression. Longer-term longitudinal studies of social cognition in depression are needed. Treatment was pharmacological and non-manualized psychotherapy, the effects of which were not controlled for. Sample sizes were modest, which must caution against generalization of the results.
Management for severe Crohn's disease: A lifetime cost-utility analysis

Objectives: Infliximab is a costly therapy for active Crohn's disease resistant to corticosteroids and immunosuppressive medication. The purpose of this study was to examine whether a treatment including infliximab (episodic re-infusions for relapse or maintenance therapy every 8 weeks) was relevant compared with conventional management (surgery and medical treatment without infliximab) for nonfistulizing resistant Crohn's disease. Methods: We performed a life-time cost-utility analysis with an analytic Markov decision model from the perspective of the third-party payer system. Utility measurement using Standard Gamble was used to adjust the survival time for each health state of the disease. Direct costs were estimated from standard management based on expert opinion. A sensitivity analysis was conducted to gauge the effects of uncertainty in the values assigned to variables. Results: The incremental effectiveness with infliximab therapy is . 761 Quality-Adjusted Life Years (QALYs) for an added cost ranging from 48,478.79 euros to 596,990.35 euros, depending on treatment procedure. The incremental cost utility ratio expressed in euros per QALYs saved varied from 63,700.82 euros (episodic re-infusions) to over 762,245.09 euros (maintenance therapy). Conclusions: Infliximab therapy could be cost-effective in the case of relapse treatment only, whereas the marginal cost-utility ratio exceeds conventional benchmarks for maintenance therapy. This analysis will be supplemented by conducting further randomized controlled trials and prospective observational study, focused on the costs of illness (direct and indirect), patient preferences, the disease's clinical course, and infliximab safety.
Effect of sleep on gross motor memory

Sleep has a beneficial effect on consolidation of newly learned fine motor skills. The aim of the current study was to determine whether sleep has a similar beneficial effect on consolidation of gross motor skills. A total of 70 participants were randomly assigned to either a Sleep-Wake group or a Wake-Sleep group and were trained on an arm coordinated reaching task as a gross motor skill. Initial training occurred in the evening for the Sleep-Wake group and in the morning for the Wake-Sleep group. All participants attended two test sessions 12 and 24 hours following the initial training. Gross motor skill performance improved in both groups following a night of sleep but not after a day of wakefulness. These findings may have implications for learning of new gross motor skills in a range of activities from dance to motor rehabilitation.
Critique as Collaboration in Design Anthropology

Design anthropology is an emerging field at the intersection of design and anthropology with a distinct style of knowing. This paper argues that in order to create transdisciplinary practices around collaboration for design anthropology, the field must understand existing practices of critique in the field of design. Based on a two-year National Science Foundation funded study of collaboration with designers and design educators in four countries, this article describes the culture of critique that underpins the collaborative practices of designers. In particular, designers often participate in a studio-based culture of critique, which is learned in art and design schools, even when it is not explicitly taught. Finally, as the field of design anthropology matures to include global networks of scholars and practitioners, it is useful to consider the ways in which emergent practices of critique as collaboration, supported by digital platforms, might move beyond the design studio and into distributed collaborations.
Children of Mentally Ill Mothers: Mental Development, Somatic Growth and Social Outcome

A two-year cohort of children of parapartum mentally ill mothers born in Stockholm during the mid-70s was studied with regard to mental development, somatic growth and social outcome. The observation period covered the pre-school-age period and the study was based on Well-Baby-Clinic (WBC) data. The findings were compared with those of matched controls. Nearly 40% of the children of the mentally ill mothers, compared to 3% of the controls, did not live with their biological mothers during the pre-school ages. No difference was found in somatic growth between the index and control children. However, more index children—especially those of addicts and neurotic or temporarily insufficient mothers—than controls suffered from developmental (p<0.05) and behavioural (p<0.001) disturbances. Fifteen per cent of the index children compared to 5% of the controls were judged by the staff of the WBC to be in need of treatment for psychological problems (p<0.01). The results of the present study emphasize the fact that children of mentally ill mothers constitute a high-risk group regarding mental and behavioural development. The study supports earlier research reports claiming that, while parental mental illness constitutes an important indicator of psychiatric risk for the children, the main risk stems from associated psycho-social disturbances in the family.
SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study

Several lines of evidence suggest that alterations in circadian rhythms might be associated with the pathophysiology of psychiatric disorders such as schizophrenia and bipolar disorder (BP). A recent study reported that SIRT1 is a molecule that plays an important role in the circadian clock system. Therefore, to evaluate the association among the SIRT1 gene, schizophrenia and BP, we conducted a case–control study of Japanese population samples (1158 schizophrenia patients, 1008 BP patients and 2127 controls) with four tagging SNPs (rs12778366, rs2273773, rs4746720 and rs10997875) in the SIRT1 gene. Marker‐trait association analysis was used to evaluate the allele and the genotype association with the χ2 test, and haplotype association analysis was evaluated with a likelihood ratio test. We showed an association between rs4746720 in the SIRT1 gene and schizophrenia in the allele and the genotype analysis. However, the significance of these associations did not survive after Bonferroni's correction for multiple testing. On the other hand, the SIRT1 gene was associated with Japanese schizophrenia in a haplotype‐wise analysis (global Pall markers = 4.89 × 10−15). Also, four tagging SNPs in the SIRT1 gene were not associated with BP. In conclusion, the SIRT1 gene may play an important role in the pathophysiology of schizophrenia in the Japanese population.
Accruals quality and the cost of debt: the European evidence

Purpose This paper aims to investigate the empirical relationship between the cost of debt (CoD) and accruals quality (AQ) of European listed firms during the period of 2005 to 2014. Also, it aims to test the impact of the interrelationship between the financial crisis (2008-2009) and AQ on CoD. Finally, we decompose AQ into two components; the innate (InnateAQ) and discretionary components (DiscAQ); and test their relationships with CoD. Design/methodology/approach To empirically examine the relationship between AQ and CoD, a sample including 15 member states of the EU is constructed. AQ proxy is based on the McNichols (2002) modification of Dechow and Dichev (2002) model. A univariate analysis and a multivariate analysis are conducted to examine the relationship between AQ and CoD after controlling for firm characteristics and institutional variables. Findings We find a significant negative association between AQ and CoD in a vast proportion of the 15 countries under review. Also, the results indicate that during the crisis period, creditors pay relatively more attention to the quality of accounting information than during the pre-crisis period when they determine CoD of firms. Moreover, we report a link between the magnitude of this relationship and national characteristics and provide evidence of the significant effects of national characteristics and market forces on CoD. Finally, we find that InnateAQ drives the relationship with CoD. Practical implications This paper provides up-to-date evidence on the economic consequences of AQ and IFRS in the capital market. The results should, therefore, be of interest to managers, creditors, regulators and standard-setters. Originality/value To the best of the authors’ knowledge, this is the first paper to investigate the effects of AQ on CoD for European listed firms. Also, it examines the impact of financial crisis on the association between AQ and CoD.
Psychologists Are Open to Change, yet Wary of Rules

Psychologists must change the way they conduct and report their research—this notion has been the topic of much debate in recent years. One article recently published in Psychological Science proposing six requirements for researchers concerning data collection and reporting practices as well as four guidelines for reviewers aimed at improving the publication process has recently received much attention (Simmons, Nelson, & Simonsohn, 2011). We surveyed 1,292 psychologists to address two questions: Do psychologists support these concrete changes to data collection, reporting, and publication practices, and if not, what are their reasons? Respondents also indicated the percentage of print and online journal space that should be dedicated to novel studies and direct replications as well as the percentage of published psychological research that they believed would be confirmed if direct replications were conducted. We found that psychologists are generally open to change. Five requirements for researchers and three guidelines for reviewers were supported as standards of good practice, whereas one requirement was even supported as a publication condition. Psychologists appear to be less in favor of mandatory conditions of publication than standards of good practice. We conclude that the proposal made by Simmons, Nelson & Simonsohn (2011) is a starting point for such standards.
A Facile Spectrophotometric Method for Cobalt Determination Using α-Benzilmonoxime in Sodium Dodecylsulfate Micellar Solutions

α-Benzilmonoxime in sodium dodecylsulfate micellar media has been used for the spectrophotometric determination of cobalt at pH 9.0. The linear range of calibration is 0.05–1.50 pg cm^-3 of cobalt at 380 nm with molar absorptivity of 3.72 × 10^4 dm^3 mol^-1 cm^-1, which is about 1.5-times greater than that of the α-benzilmonoxime extraction based method. The relative standard deviations, recoveries, detection limit and effects of diverse ions on the determination of cobalt were studied. These analytical results were satisfactory. The method was successfully applied to the determination of cobalt in the various samples.
Leverage Network and Market Contagion

Using detailed data of margin investors’ leverage ratios and trading activities, we provide novel evidence for the effect of margin-induced trading on the cross-section of stock returns during the recent market turmoil in China. We first document the deleverge-induced sales. Aggregating this behavior across margin investors, we find a significant return spillover: a stock’s return can be strongly forecasted by a portfolio of stocks with which it shares common margin investor ownership. This pattern is subsequently reversed, and is present only in market downturns. Exploiting three government bailout waves of the stock market, we provide additional evidence for the shock transmission role of, and the systematic importance of central stocks in the leverage network.
N‐acetylcysteine prophylaxis significantly reduces the risk of radiocontrast‐induced nephropathy: Comprehensive meta‐analysis

The objectives of this study was to assess the overall effect of N‐acetylcysteine (NAC) in preventing radiocontrast‐induced nephropathy (RCIN) using all available data in the literature. RCIN is associated with increased morbidity and mortality. Existing randomized trials of NAC are small and show inconsistent results. Prior meta‐analyses do not include data from the most current studies. We used standard search protocols to identify all published articles and abstracts of prospective trials using NAC with fluid hydration compared to hydration alone in patients with chronic renal insufficiency undergoing contrast procedures. A rise in serum creatinine by 0.5 mg/dl or 25% above baseline at 48–72 hr after contrast exposure was used as the primary outcome. We identified 14 trials of NAC with 1,584 patients published as full‐text articles. Using a random‐effects model, the use of oral NAC resulted in a significant reduction in the risk for developing RCIN (RR = 0.57; 95% CI = 0.37–0.84; P = 0.01). This finding did not significantly change in a fixed‐effect model (RR = 0.55; 95% CI = 0.42–0.73) or when the data were reanalyzed using only randomized trials in all forms (i.e., articles and abstracts; RR = 0.67; 95% CI = 0.47–0.95). We identified only one important difference between the positive and the negative studies: the cumulative exposure to contrast media (174 vs. 152 ml). Metaregression did not show a significant relationship between contrast volume and the RR of developing RCIN (P > 0.10). In the trials showing benefit for NAC, the treated patients' postprocedure creatinine unexpectedly decreased by 0.21 mg/dl (95% CI = 0.33–0.08). Prophylaxis with NAC significantly reduces the risk for RCIN. The reasons for improvement in serum creatinine in patients treated with NAC are unclear, but may include improved renal blood flow due to NAC and/or vigorous hydration. Catheter Cardiovasc Interv 2005;64:471–479. © 2005 Wiley‐Liss, Inc.
Comparing the Technology Trajectories of Solar PV and Solar Water Heaters in China: Using a Patent Lens

China invests more in renewable energy than any other countries, such as in solar energy. The traditional literature maintains that these government-supported industries are more innovative than grassroots industries such as solar or thermal, which leads to debate. This study uses mixed methods, combining qualitative and quantitative approaches to compare the technology trajectories of leading solar water heater (SWH) and solar photovoltaic (PV) firms in China. It concentrates on the following three aspects: trajectories of key technologies, patent citation network, and type of collaboration. Our analyses show that technology trajectories differ significantly between leading SWH firms and PV firms in China. We find that the Chinese SWH firms are core to international knowledge networks, and are following a market-driven innovation mode. In contrast, Chinese PV firms are close to the center of the network and government-driven. Research suggests that grassroots innovation, by doing, using, and interaction (DUI), can create short-term market development models relying on China’s traditional industry model, but cannot create a long-term international leading innovation model; only integrated science, technology, innovation modes (STI), and DUI innovation modes tend to result in international leadership in innovation.
Kinematic Analysis of Suction Feeding in the Nurse Shark, Ginglymostoma cirratum (Orectolobiformes, Ginglymostomatidae)

Abstract Inertial suction feeding is known to occur in some sharks, but the sequence and temporal kinematics of head and jaw movements have not been defined. We investigated the feeding kinematics of a suction feeding shark, the nurse shark Ginglymostoma cirratum, to test for differences in the timing and magnitude of feeding components with other shark taxa when sharks were fed pieces of bony fish. Thirteen kinematic variables were measured from high-speed video recordings. Food capture in this species consists of expansive, compressive, and recovery phases, as in most other sharks, but there is little or no cranial elevation. Mean time to maximum gape (32 msec) is the fastest recorded for an elasmobranch fish. Other relatively rapid events include mandibular depression (26 msec), elevation (66 msec), and total bite time (100 msec). Buccal valves assist the unidirectional flow of water into the mouth and out of the gill chambers. Food capture under these experimental conditions appears to be a stereotyped modal action pattern but with significant interindividual variability in timing of kinematic events. Ginglymostoma cirratum exhibits a suite of specializations for inertial suction feeding that include (1) the formation of a small, anteriorly directed mouth that is approximately round and laterally enclosed by modified labial cartilages; (2) small teeth; (3) buccal valves to prevent the backflow of water; and (4) extremely rapid buccal expansion. Sharks that capture food by inertial suction have faster and more stereotyped capture behavior than sharks that primarily ram feed. Inertial suction feeding, which has evolved multiple times in sharks, represents an example of functional convergence with inertial suction feeding bony fishes.
Forthcoming prognostic markers for esophageal cancer: a systematic review and meta-analysis.

BACKGROUND The incidence of esophageal cancer is rising, and survival rates remain poor. This meta-analysis summarizes five molecular mechanisms of disease progression, which are related to prognosis. PATIENTS AND METHODS A systematic search was conducted using MEDLINE, PubMed, EMBASE, Current Contents Connect, Cochrane library, Google Scholar, Science Direct, and Web of Science. Original data was abstracted from each study and used to calculate a pooled event rate and 95% confidence interval (95% CI). RESULTS Our analysis included five octamer-binding transcription factor 4 (OCT4) studies (564 patients), six sex determining region Y-box 2 (SOX2) studies (336 patients), five oestrogen receptor (ER) studies (367 patients), seven MET or MNNG HOS Transforming gene (c-Met) studies (1,015 patients) and six insulin like growth factor receptor studies (764 patients). Incidence of OCT4 in SCC was 53.60% (95% CI: 0.182-0.857) and the overall hazard ratio for poor clinic outcome was 2.9 (95% CI: 1.843-4.565). The incidence of SOX2 in SCC was 69.2% (95% CI: 0.361-0.899) however, was associated with significant heterogeneity of 90.94%. The prevalence of Oestrogen receptor α and β in SCC were 37.90% (95% CI: 0.317-0.444) and 67.20% (95% CI: 0.314-0.901) respectively. The prevalence of MET in EAC was 33.20% (95% CI: 0.031-0.884) and the incidence of insulin-like growth factor-1 receptor (IGF-1R) in EAC was 67.70% (95% CI: 0.333-0.898). CONCLUSIONS Our results show that the status of ER, OCT4 and SOX2 expression correlates with the unfavourable prognosis in patients with esophageal squamous cell carcinoma (ESCC). This study also highlights the potential impact of the IGF-1R on the biology of EAC and the expression of Met was recognised as a significant prognostic factor. Our data supports the concept of IGF axis, ER, Met, OCT4 and SOX2 inhibition as (neo-) adjuvant treatment.
Diversity of Plasmids and Antimicrobial Resistance Genes in Multidrug‐Resistant Escherichia coli Isolated from Healthy Companion Animals

The presence and transfer of antimicrobial resistance genes from commensal bacteria in companion animals to more pathogenic bacteria may contribute to dissemination of antimicrobial resistance. The purpose of this study was to determine antimicrobial resistance gene content and the presence of genetic elements in antimicrobial resistant Escherichia coli from healthy companion animals. In our previous study, from May to August, 2007, healthy companion animals (155 dogs and 121 cats) from three veterinary clinics in the Athens, GA, USA area were sampled and multidrug‐resistant E. coli (n = 36; MDR, resistance to ≥2 antimicrobial classes) were obtained. Of the 25 different plasmid replicon types tested by PCR, at least one plasmid replicon type was detected in 94% (34/36) of the MDR E. coli; four isolates contained as many as five different plasmid replicons. Nine replicon types (FIA, FIB, FII, I2, A/C, U, P, I1 and HI2) were identified with FIB, FII, I2 as the most common pattern. The presence of class I integrons (intI) was detected in 61% (22/36) of the isolates with eight isolates containing aminoglycoside‐ and/or trimethoprim‐resistance genes in the variable cassette region of intI. Microarray analysis of a subset of the MDR E. coli (n = 9) identified the presence of genes conferring resistance to aminoglycosides (aac, aad, aph and strA/B), β‐lactams (ampC, cmy, tem and vim), chloramphenicol (cat), sulfonamides (sulI and sulII), tetracycline [tet(A), tet(B), tet(C), tet(D) and regulator, tetR] and trimethoprim (dfrA). Antimicrobial resistance to eight antimicrobials (ampicillin, cefoxitin, ceftiofur, amoxicillin/clavulanic acid, streptomycin, gentamicin, sulfisoxazole and trimethoprim‐sulfamethoxazole) and five plasmid replicons (FIA, FIB, FII, I1 and I2) were transferred via conjugation. The presence of antimicrobial resistance genes, intI and transferable plasmid replicons indicate that E. coli from companion animals may play an important role in the dissemination of antimicrobial resistance, particularly to human hosts during contact.