Miracle-dz/UniFAR-FTUs huggingface dataset:
p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2

The progression of normal cells from G2 into mitosis is stably blocked when their DNA is damaged. Tumor cells lacking p53 arrest only transiently in G2, but eventually enter mitosis. We show that an important component of the stable G2 arrest in normal cells is the transcriptional repression of more than 20 genes encoding proteins needed to enter into and progress through mitosis. Studies from a number of labs including our own have shown that, by inducing p53 and p21/WAF1, DNA damage can trigger RB-family-dependent transcriptional repression. Our studies reported here show that p130 and p107 play a key role in transcriptional repression of genes required for G2 and M in response to DNA damage. For plk1, repression is partially abrogated by loss of p130 and p107, and is completely abrogated by loss of all three RB-family proteins. Mouse cells lacking RB-family proteins do not accumulate with a 4N content of DNA when exposed to adriamycin, suggesting that all three RB-family proteins contribute to G2 arrest in response to DNA damage. Stable arrest in the presence of functional p53-to-RB signaling is probably due to the ability of cells to exit the cell cycle from G2, a conclusion supported by our observation that KI67, a marker of cell-cycle entry, is downregulated in both G1 and G2 in a p53-dependent manner.
Deflation Methods in Fermion Inverters

I will review recent developments in matrix deflation methods, by Ronald Morgan/Walter Wilcox, Andreas Stathopoulos/Konstantinos Orginos, and Martin L\"uscher, with application to lattice QCD fermion inversion. I will begin with a short review of deflation-related work in the field. The Morgan/Wilcox algorithms using GMRES and BiCGStab for deflation will be described. Typical results for quenched (Wilson and twisted mass) and dynamical configurations (CP-PACS and ETMC) will be displayed and discussed. I will outline how inclusion of multiple right-hand sides and multiple shifts can be accommodated within versions of these methods. I will also review deflation methods based on Conjugate Gradient introduced by Stathopoulos and Orginos for hermitian systems with multiple right-hand sides as well as L\"uscher's non-hermitian domain decomposition algorithm using Generalized Conjugate Residual. }
Optimizing regular path expressions using graph schemas

Query languages for data with irregular structure use regular path expressions for navigation. This feature is useful for querying data where parts of the structure is either unknown, unavailable to the user, or changes frequently. Naive execution of regular path expressions is inefficient however, because it ignores any structure in the data. We describe two optimization techniques for queries with regular path expressions. Both rely on graph schemas for specifying partial knowledge about the data's structure. Query pruning uses this structure to restrict navigation to only a fragment of the data; we give an efficient algorithm for rewriting any regular path expression query into a pruned one. Query rewriting using state extents can eliminate or reduce navigation altogether; it is reminiscent of optimizing relational queries using indices. There may be several ways to optimize a query using state extents; we give a polynomial space algorithm that finds all such optimizations. For restricted forms of regular path expressions, the algorithm is provably efficient. We also give an efficient approximation algorithm that works on all regular path expressions.
Conditional genome alteration in mice

The recent ability to inactivate specific genes in mice has significantly accelerated our understanding of molecular, cellular, and even behavioral aspects of normal and disease processes. However, this ability has also demonstrated the extreme complexity of genetic determination in mammals, in particular, that genes in the same family or pathway can be functionally redundant and that a given gene often has multiple roles. Thus, inactivation of a gene often does not indicate its complete spectrum of functions. To circumvent this problem, many new tools and novel applications of classic techniques have been developed to place spatial and temporal restrictions on the genomic alterations. These approaches include chimera and mosaic studies, organ transplantation, complementation assays, dominant negative mutants, conditional gene knockouts, and lineage‐specific gene rescue. Not only has this opened up more sophisticated ways to make genomic alterations, but it has provided the opportunity to create animal models for sporadic human genetic diseases. BioEssays 20:200–208, 1998. © 1998 John Wiley & Sons, Inc.
Self-Organizing Word Map for Context-Based Document Classification

In this paper, a novel SOM-based system for document organization is presented. The purpose of the system is the classification of a document collection in terms of document content. The system possesses a two- level hybrid connectionist architecture that comprises (i) an automatically created word map using a SOM, which functions as a feature extraction module and (ii) a supervised MLP-based classifier, which provides the final classification result. The experiments, which have been performed on Modern Greek text documents, indicate that the proposed system separates effectively the different types of text.
Design and Implementation of a Wearable Safety Suit

Wearable computing promises gaining efficiency improvements in industrial applications due to augmentation of sensing and computational devices, thus improving the interaction between the user and the machine interface. Devices such as head mounted displays (HMDs) or wrist-mounted computers help delivering tailored information to the user while enabling hands-free operations. Sensors sewn into clothing increase the safety of maintenance and service staff by collecting information related to environmental conditions such as gas levels or temperature as well as health conditions of the wearer. In this paper, we present a wearable safety suit which integrates various sensors and is operated via a mobile device. In our prototype, we use different types of sensors for monitoring environmental and health conditions like temperature, carbon monoxide (CO) gas levels, relative humidity, body temperature, and heartbeat. The wearable safety suit is controlled via a mobile application. The latter monitors the sensor data, identifies environmental changes, and provides alerts to the user and/or a remote control center. Keeping the usage of wearable safety suit in mind, the system is designed in a user friendly manner.
Model-based verification of the SIP invite scenario

The Session Initiation Protocol (SIP) is a signaling protocol for multimedia control over the Internet. It is used for initiating, maintaining and terminating multimedia sessions. In this paper we have carried out the verification of the SIP Invite scenario with Coloured Petri nets (CP-nets or CPNs). First, we have specified and verified the protocol model using a simulation tool. Then, we have verified the scenario using a state space analysis tool. We have concluded that the SIP Invite transaction is free of livelocks, and has only desirable deadlocks. Therefore, no additional remodeling for the protocol Invite transaction is needed.
A novel blink detection system for user monitoring

As the amount of time that the average person spends interacting with computing devices increases, it becomes important for the devices to be able to adjust to the user's state. Blinks are known to be indicative of the emotional state of a person and detecting blink patterns of a computer user can lead to devices that comprehend the user's state and adjust their characteristics accordingly. In this paper we propose a method to reliably detect blinks by analysing the motion vectors in the face and eye regions. It consists of three main steps: detecting the face and eye regions in the image, calculating the motion field in the face region and finally, exploiting the level of similarity between the vectors in the eye and face regions to distinguish images containing blinks from those that do not. Our algorithm is able to detect blinks even in images where the head is tilted or is moving - conditions that are very important for practical applications. We have achieved an accuracy of 96.9% in our experiments.
TourisT: the application of a description logic based semantic hypermedia system for tourism

Web-based Public Information Systems of the kind common in tourism do not satisfy the needs of the customer because they do not offer a sufficiently flexible linking environment capable of emulating the mediation role of a tourist adviser. We present the requirements of a tourism hypermedia system resulting from ethnographic studies of tourist advisers, and conclude that an open semantic hypermedia (SH) approach is appropriate. We present a novel and powerful SH prototype based on the use of a semantic model expressed as a terminology. The terminological model is implemented by a Description Logic, GRAIL, capable of the automatic and dynamic multi-dimensional classification of concepts, and hence the web pages they describe, We show how GRAIL-Link has been used within the TourisT hypermedia system and conclude with a discussion.
Distrust: Not Only in Secret Service Organizations

In this article, we discuss the issue of distrust in the most extreme example of distrustful organizations: secret service organizations. Distrust may be a basic organizing principle in such organizations, but how is it produced and maintained? Inspired by actor–network theory, we analyzed the devices, codes, rules, and procedures used in secret service organizations, and then asked whether these devices, codes, rules, and procedures differ from those used in ordinary organizations. Based on our analysis, we make two contributions. First, we draw researchers’ attention to distrust that is intentionally built and maintained rather than distrust that is accidental and indicative of faulty management. Second, we identify the material manifestations of distrust. We argue that in future studies of trust and distrust in organizations, it will be necessary to focus on the technologies, physical objects, and quasi-objects. These, together with discourses, guarantee the stability of connections among organizational actions.
Relation Extraction for Semantic Intranet Annotations

We present an approach for ontology driven extraction of relations fr m texts aimed mainly to produce enriched semantic annotations for the Semantic Web. The approach exploits linguistic and empirical strategies, by means of a pipeline me thod involving processes such as a parser, part-of-speech tagger, named entity recognition sys tem, and pattern-based classification, and resources including ontology, knowledge and lexic a databases. A preliminary evaluation with 25 sentences showed that the use of knowledge intensive resources and strategies together with corpus-based technique s to process the input data allows identifying and discovering relevant relations between k nown and new entity pairs mentioned in the text. Besides semantic web annotations, the sys tem can be used for other tasks, including ontology population, since it identifies new instanti ations of existent relations and entities, and ontology learning, since it discovers ne w relations, which are not part of the ontology.
Nonlinear additive Schwarz preconditioners and applications in computational fluid dynamics

The focus of this paper is on the numerical solution of large sparse nonlinear systems of algebraic equations on parallel computers. These nonlinear systems often arise from the discretization of nonlinear partial di erential equations, such as the Navier-Stokes equations for uid ows, using nite element or nite di erence methods. Traditional inexact Newton method, applied directly to the discretized system, does not work well when the nonlinearities in the algebraic system become unbalanced. In this paper we study some preconditioned inexact Newton algorithms including the single-level and multilevel nonlinear additive Schwarz preconditioners. Some results for solving the high Reynolds number incompressible Navier-Stokes equations will be reported.
Multilingualism for Europeans, monolingualism for immigrants? Towards policy-based inclusion of immigrant minority language students in Content and Language Integrated Learning (CLIL)

Abstract:This article sets out an argument in favour of policy-based provision for immigrant minority language (IM) students' inclusion in and access to plurilingual Content and Language Integrated Learning (CLIL) programmes. First, it provides a summary of the research evidence on these students' achievement in CLIL programmes, and the motivations underlying their families' choice for these programmes. Next, after evaluating existing educational support provisions for immigrant minority language students, it is shown how CLIL programmes are capable of providing IM students with educational opportunities and effective pedagogical support which existing mainstream monolingual and minority bilingual education programmes may not. Finally, the article examines European and national policies in terms of the extent to which they facilitate or hamper the inclusion of immigrant minority language students in CLIL programmes. Résumé:Cet article document présente une argumentation en faveur d'une offre basée sur des politiques pour l'inclusion et l'accès des élèves immigrés de langue minoritaire aux programmes plurilingues d'apprentissage intégré du contenu et de la langue (EMILE/CLIL). D'abord, il fournit un résumé des données de recherche sur la réussite de ces élèves dans les programmes EMILE/CLIL, et les motivations sous-jacentes au choix de leurs familles pour ces programmes. Ensuite, après avoir évalué les mesures de soutien éducatif existantes pour les étudiants immigrés en langues minoritaires, il montre comment les programmes EMILE/CLIL sont capables d'offrir aux étudiants immigrés de langue minoritaire des opportunités éducatives et un soutien pédagogique efficace que ne peuvent pas offrir les programmes courants d'éducation monolingue et minoritaire bilingue. Enfin, le document examine les politiques européennes et nationales en termes de la mesure dans laquelle elles facilitent ou entravent l'inclusion des élèves immigrés appartenant à une minorité linguistique dans les programmes EMILE/CLIL.
The Existence of Street Vendors PKL as Supporting Activities in Jalan Taman Siswa Semarang

Sekaran area has rapidly developed nowadays, especially the development of street vendors’ existence as the facility of fulfilling students’ needs from the very first establishment of Unnes. There is not only street vendors’ phenomenon but also there exist change of land function, the development of building and traffic density. Several additional activities to the developed area would relatively increase such impacts towards street vendor development in Sekaran, especially in Jalan Taman Siswa. This phenomenon is interesting to be studied because a part of Jalan Taman Siswa becomes one of the important corridors in Semarang State University area. This corridor, unfortunately, has been changed into the center of street vendors.The data collecting employed by the writer was observation, interview, and documentation. This study employs qualitative approach. Whereas the method used is descriptive design. By implementing this method, the writer will elaborate the problems appeared briefly and comprehensively. Theoretical data are collected by reviewing the related literature, which means that the writer gathers the data by reading much relevant literature. This data is managed by conducting analysis and applying the data to the study. The existence of Unnes as one of the big campuses in Semarang triggers the occurrence of several students' activities such as to fulfill students' daily necessity. Along Kinanti boarding house to Ulul Albab Mosque, there exist several supporting facilities for Unnes students and people around the campus. This is interesting since the occurrence of supporting activity such as PKL in that area has the strong relationship with the use of public spaces. Thus, it could be formulated that the presence of PKL as activity support in Taman Siswa corridor increases along with the development of Semarang State University Campus.
Use of Livestock Guarding Animals to Reduce Predation on Livestock

) has been a major problem faced bydomestic sheep, goat (NASS, 2000), andcattle (NASS, 2001) producers. Preda-tors were reported to kill 273,000 sheepand lambs (NASS, 2000) and 147,000cattle and calves (NASS, 2001) in theUnited States, and 61,000 goats in Ari-zona, New Mexico, and Texas (NASS,2000) during either 1999 or 2000. Sev-eral methods, including the use of live-stock guarding dogs, llamas, and don-keys, have been used to reduce thesemortalities (Andelt, 1996, 2001). In thispaper, I summarize use and effectivenessof livestock guarding animals for reduc-ing predation on domestic sheep andgoats. Recent reviews of livestock guard-ing animals are provided by Smith et al.(2000) and Rigg (2001).
A security solution to the Points-Hyperspace Inclusion problem

Privacy-preserving computational geometry (PPCG) is a Secure Multi-party Computation problem. Determining the relationship of a point and a hyperspace is a security of the points-range inclusion problem which is one of PPCG problems. This paper studies the special SMC protocols to solve the special computational geometry problem, uses random technology to improve efficiency, so that it can be better used in online transactions and other applications. Firstly, a protocol for the Points-Rectangle Area Inclusion problem which is based on multiplication protocol is developed. Then a probability algorithm for Points-Hyperspace Inclusion problem is presented. The probability algorithm is proved that it is a true-biased Monte Carlo algorithm. Both of the theoretical analysis and the experiment results show that the probability algorithm is efficient.
Hanging ability in climbing: an approach by finger hangs on adjusted depth edges in advanced and elite sport climbers

ABSTRACT Hanging ability on small depth edges is one of the most limiting factors in climbing. The aim of this study was to assess the reliability and validity of a hanging ability indicator measured on an adjusted depth edge. Forty voluntary sport climbers (34 men) were divided into an advanced group (AG; n = 22) and an elite group (EG; n = 18). Climbers performed three sustained finger tests following a test–retest design: (a) maximum hanging time on a 14-mm edge depth (MHT_14), (b) minimum edge depth in which climbers could hang for 40 s exactly (MED_40) and (c) maximum added weight test on the MED_40 edge depth (MAW_5). EG performed better than AG in all tests. The regression analyses showed that the MHT_14 test and MAW_5 test explained a 35% and 69% of the climbing sport level in AG and EG, respectively. All the tests were reliable (ICC3,1 values ranging from 0.89 to 1.00). The MAW_5 and MHT_14 tests demonstrated to be valid and reliable hanging ability indicators for EG and AG, respectively. The measurement of hanging ability on adjusted depth edges might be a key factor in elite climbers, but not necessary in lower level climbers.
Phrasal Verbs and the LinGO-ERG

In this paper we investigate the phenomenon of phrasal verbs , discussing their characteristics and the challenges that they present for possible treatments. We al so discuss the treatment for phrasal verbs in a particular grammar, the LinGO-ERG, and the coverage it prov ides. Possible ways of extending the coverage of this grammar are analysed and proposed, taking into accou nt the regular patterns found in some productive combinations of verbs and particles.
Kinematics of Spiral-Arm Streaming in M51

We use CO and Hα velocity fields to study the gas kinematics in the spiral arms and interarms of M51 (NGC 5194), and fit the 2D velocity field to estimate the radial and tangential velocity components as a function of spiral phase (arm distance). We find large radial and tangential streaming velocities, which are qualitatively consistent with the predictions of density wave theory and support the existence of shocks. The streaming motions are complex, varying significantly across the galaxy as well as along and between arms. Aberrations in the velocity field indicate that the disk is not coplanar, perhaps as far in as 20'' (800 pc) from the center. Velocity profile fits from CO and Hα are typically similar, suggesting that most of the Hα emission originates from regions of recent star formation. We also explore vortensity and mass conservation conditions. Vortensity conservation, which does not require a steady state, is empirically verified. The velocity and density profiles show large and varying mass fluxes, which are inconsistent with a steady flow for a single dominant global spiral mode. We thus conclude that the spiral arms cannot be in a quasi-steady state in any rotating frame, and/or that out-of-plane motions may be significant.
The Second Workshop on Statistical Parsing of Morphologically Rich Languages ( SPMRL

This paper gives two contributions to dependency parsing in Korean. First, we build a Korean dependency Treebank from an existing constituent Treebank. For a morphologically rich language like Korean, dependency parsing shows some advantages over constituent parsing. Since there is not much training data available, we automatically generate dependency trees by applying head-percolation rules and heuristics to the constituent trees. Second, we show how to extract useful features for dependency parsing from rich morphology in Korean. Once we build the dependency Treebank, any statistical parsing approach can be applied. The challenging part is how to extract features from tokens consisting of multiple morphemes. We suggest a way of selecting important morphemes and use only these as features to avoid sparsity. Our parsing approach is evaluated on three different genres using both gold-standard and automatic morphological analysis. We also test the impact of fine vs. coarse-grained morphologies on dependency parsing. With automatic morphological analysis, we achieve labeled attachment scores of 80%. To the best of our knowledge, this is the first time that Korean dependency parsing has been evaluated on labeled edges with such a large variety of data.
Exploiting human cooperation in human-centered robot navigation

Robot path planning has traditionally concentrated on collision-free paths. For robots that collaborate closely with humans, however, the situation is different in two respects: 1) the humans in the robot's environment are not randomly moving objects, but cognitive beings who can deliberately make way for a robot to pass and 2) the quality of a navigation plan depends less on quantitative efficiency criteria, but rather on the acceptance of humans. In this paper, we introduce a robot navigation approach that takes into account human-centered requirements and the collaborative nature of the interaction between the human and the robot.