Miracle-dz/UniFAR-FTUs huggingface dataset:
Melatonin Prevents Oxidative Stress and Hepatocyte Cell Death Induced by Experimental Cholestasis

The induction of oxidative stress precedes liver injury during experimental obstructive jaundice (OJ). In this sense, different evidences suggest that melatonin (MEL), as antioxidant, may be useful in the protection against apoptosis and necrosis during experimental cholestasis. In addition, we will also assess if MEL-dependent protection is related to a recovery of antioxidant status disturbances induced by OJ. Cholestasis was achieved by double ligature and sectioning of the principal bile duct. MEL was injected intraperitoneally (500 μg/kg/day). Lipid peroxidation was evaluated by the measurement of malondialdehyde (MDA) content in liver. Different parameters related to antioxidant status, such as reduced glutathione (GSH), glutathione peroxidase (GPx), catalase and superoxide dismutase (SOD) were determined in liver. Liver injury was assessed by alanine aminotransferase (ALT) in serum, histological examination, DNA fragmentation and TUNEL assay. The activation of perisinusoidal stellate cells was evaluated by immunohistochemical measurement of α-smooth muscle actin in liver sections. The induction of OJ increased all the parameters related to apoptosis and necrosis in liver. The induction of liver injury was associated with stellate cell activation, as well as an increase in MDA (p<0.0001) and a reduction in GSH, GPx, catalase and SOD content (p<0.0001) in liver. MEL reduced hepatic apoptosis and necrosis (p<0.004) with a significant improvement in all oxidative stress markers. In conclusion, our results showed that MEL recovered the antioxidant status and reduced apoptosis and necrosis induced by experimental cholestasis.
Condition‐dependent genetic benefits of extrapair fertilization in female blue tits Cyanistes caeruleus

In many socially monogamous birds, both partners perform extrapair copulations (EPC). As this behaviour potentially inflicts direct costs on females, they are currently hypothesized to search for genetic benefits for descendants, either as ‘good’ or ‘complementary’ genes. Although these hypotheses have found some support, several studies failed to find any beneficial consequence of EPC, and whether this behaviour is adaptive to females is subject to discussion. Here, we test these two hypotheses in a natural population of blue tits by accounting for the effect of most parameters known to potentially affect extrapair fertilization. Results suggest that female body mass affected the type of extrapair genetic benefits obtained. Heavy females obtained extrapair fertilizations when their social male was of low quality (as reflected by sexual display) and produced larger extrapair than within‐pair chicks. Lean females obtained extrapair fertilizations when their social mate was genetically similar, thereby producing more heterozygous extrapair chicks. Our results suggest that mating patterns may be condition‐dependent.
A net carbohydrate and protein system for evaluating cattle diets: IV. Predicting amino acid adequacy.

The Cornell Net Carbohydrate and Protein System was modified to include an amino acid submodel for predicting the adequacy of absorbed essential amino acids in cattle diets. Equations for predicting the supply of and requirements for absorbed essential amino acids are described and presented. The model was evaluated for its ability to predict observed duodenal flows of nitrogen, nonammonia nitrogen, bacterial nitrogen, dietary nonammonia nitrogen, and individual essential amino acids. Model-predicted nitrogen, nonammonia nitrogen, bacterial nitrogen, and dietary nonammonia nitrogen explained 93.2, 94.6, 76.4, and 79.3% of the observed duodenal flows, respectively, based on R2 values from predicted vs observed regression analysis. Based on slopes of regression lines, model-predicted duodenal nitrogen and nonammonia nitrogen were different from observed duodenal flows (P < .05), whereas model-predicted bacterial nitrogen and dietary nonammonia nitrogen were not different from observed duodenal flows (P < .05). Model-predicted duodenal flows of individual essential amino acids explained 81 to 90% of variation in observed duodenal amino acid flows. Based on slopes of regression lines, model-predicted duodenal threonine, leucine, and arginine were the only amino acids different from observed duodenal flows (P < .05). Ideas for further model improvements and research in amino acid metabolism were also presented.
Recent Surgical Results for Active Endocarditis Complicated With Perivalvular Abscess.

BACKGROUND Surgical treatment for endocarditis patients with a perivalvular abscess is still challenging.Methods and Results:From 2009 to 2016, 470 patients underwent surgery for active endocarditis at 11 hospitals. Of these, 226 patients underwent aortic valve surgery. We compared the clinical results of 162 patients without a perivalvular abscess, 37 patients who required patch reconstruction of the aortic annulus (PR group) and 27 who underwent aortic root replacement (ARR group). Patients with a perivalvular abscess had a greater number ofStaphylococcusspecies and prosthetic valve endocarditis, a greater level of inflammation at diagnosis and symptomatic heart failure before surgery, especially in the ARR group. Nevertheless, the duration between diagnosis and surgery was similar, because of a high prevalence of intracranial hemorrhage in the ARR group. Hospital death occurred in 13 (9%) patients without a perivalvular abscess, in 4 (12%) in the PR and in 7 (32%) in the ARR group. Postoperative inflammation and end-organ function were similar between the groups. Overall survival of patients without a perivalvular abscess and that of the PR group was similar, but was significantly worse in the ARR group (P=0.050, 0.026). Freedom from endocarditis recurrence was similar among all patients. CONCLUSIONS Patients treated with patch reconstruction showed favorable clinical results. Early surgical intervention is necessary when a refractory invasive infection is suspected.
Stressful life events and impulsiveness in failed suicide.

The relationship of recent stressful life events with impulsiveness in triggering suicide attempts and how impulsiveness changes from one suicide attempt to another is unclear. This study used structured-interview tools and standardized measurements to examine the relationship between life stress and impulsiveness in a sample of patients who required hospitalization for a medically serious suicide attempt. After controlling for potentially confounding variables, the number of disrupted interpersonal relationships in the preceding year was a significant predictor of the impulsiveness of the suicide attempt, with three or more losses (but not other life stresses) associated with less impulsive attempts (T = 2.4, p = .02). Female gender (T = -1.98, p = .05) and lifetime DMS-III-R diagnoses (T = -2.45, p = .02) were significantly associated with more impulsive attempts. In 55 patients with at least two suicide attempts, impulsiveness, lethal intent, and communication of intent were significantly greater for the present compared to the prior attempt (p = 0.000). Certain stressful life events, gender, and total lifetime DSM-III-R diagnoses are associated with impulsiveness of failed suicide attempts; yet, impulsiveness is not necessarily consistent from one suicide attempt to another. This evidence supports and amplifies a stress-diathesis model of suicide behavior. Accordingly, efforts to increase personal resilience in individuals who have "failed suicide" may be more effective at preventing suicide morbidity than simple stress-reduction measures alone.
Reliability and validity of the function in sitting test in nonambulatory individuals with multiple sclerosis

Poor seated balance negatively impacts the performance of activities of daily living in nonambulatory individuals with multiple sclerosis (MS) and is frequently a target of rehabilitation interventions. However, there is a lack of clinical measures of seated balance in nonambulatory individuals with MS, thus limiting evaluation of rehabilitation treatments. The aim of this investigation is to determine the reliability and concurrent validity of the Function in Sitting Test (FIST) as a measure of sitting balance in nonambulatory individuals with MS. Twenty nonambulatory individuals with MS [mean age±SD=56.8±10.9 years, women n=15 (75%), mean MS duration±SD=17.8±9.2 years, mean wheelchair usage duration±SD=5.9±4.7 years] underwent a FIST and posturography assessment. The FIST is a 14-item clinical functional assessment of sitting balance validated in adults with acute stroke. The seated posturography assessment involved participants sitting on a force platform without support for 30 s. On the basis of the center of pressure trajectory obtained from the force platform software, two force platform outcomes were quantified: sway area (mm2) of the center of pressure and virtual time to contact to the functional boundary (seconds). Internal consistency reliability was assessed using Cronbach’s coefficient-&agr;. The test–retest reliability was evaluated using the intraclass correlation coefficient (ICC). Concurrent validity of the FIST was assessed by Spearman’s rank correlation analysis. Cronbach’s-&agr; as an index of internal consistency of the FIST was 0.91. The test–retest reliability was found to be excellent (ICC=0.92). The FIST was significantly correlated with virtual time to contact to the functional boundary (&rgr;=0.487, P=0.02), but not with sway area (&rgr;=−0.267, P=0.25). The observations provide evidence that the FIST is a reliable and valid tool to assess seated postural control in nonambulatory individuals with MS.
Species-area relation for birds of the Solomon Archipelago.

Accurate values of number of breeding bird species have been obtained for 50 islands of the Solomon Archipelago. From information about species altitudinal distributions on each island, the values are apportioned into number of montane species (S(mt)) and of species present at sea-level (S(low)). S(low) increases linearly with the logarithm of island area A over a million-fold range of areas (correlation coefficient 0.99) and with a comparatively low slope, while the log S-log A relation is markedly curved. With increasing isolation of an archipelago, the species-area relation decreases in slope and may shift in form from a power function to an exponential. Comparison of Pacific archipelagoes at different distances from the colonization source of New Guinea shows that the decrease in slope is due to increasing intra-archipelago immigration rates, arising from overrepresentation of the most vagile inter-archipelago immigrants in more distant archipelagoes. When colonists are sorted into sets correlated with their dispersal abilities, the slope of the species-area relation for the most vagile set is close to zero, but for the least vagile set is close to the value predicted by Preston for "isolated universes. "
Readability of published dental educational materials.

BACKGROUND A growing number of adult Americans are functionally illiterate. These people often do not understand educational documents written by health care professionals, especially if English is the reader's second language. This problem has received little attention in dentistry. METHODS In this study, the author selected a sampling of 24 patient educational documents from several dental resources and reviewed them for readability, using a computer-based program that assigns a reading level of understanding on the basis of a standard formula known as the Flesch-Kincaid Formula. The author also conducted a subjective review of each document to identify seemingly unnecessary professional jargon and words that were unlikely to be understood by many readers. RESULTS Reading levels varied from third to 23rd grade (according to the Flesch-Kincaid Formula), and 41.7 percent of the materials were written at greater than the recommended level for understanding by most patients (mean level: seventh to ninth grade). Many dental specialty publications were written at or near college levels. Many documents had multiple grammatical errors. Seventy-nine words in the reviewed documents were considered to be jargon or potentially obscure to many lay readers. CONCLUSIONS More attention needs to be focused on the preparation of written educational materials for dental patients, to make the documents more understandable to the average patient. Guidelines for acceptable writing are available in the medical, nursing and pharmaceutical literature.
Antibody response in humans to influenza virus type B host-cell-derived variants after vaccination with standard (egg-derived) vaccine or natural infection

Hemagglutination inhibition (HI) and neutralization tests were used to determine antibody responses to egg-derived and Madin-Darby canine kidney (MDCK)-derived influenza B virus (B/England/222/82) in paired sera from persons naturally infected with influenza B and in persons vaccinated with standard egg-derived inactivated influenza vaccine. When tested by HI, the MDCK-derived antigen gave significantly higher (8- to 12-fold) geometric mean titers (GMT) in convalescent-phase sera from persons naturally infected during community outbreaks, as well as more 4-fold titer rises, than did tests with egg-derived antigen. When tested by neutralization, however, the convalescent-phase sera GMTs were only threefold higher with the MDCK-derived antigen and an equivalent number of fourfold titer rises were detected with both antigens. With postvaccine sera, the MDCK-derived antigen gave GMTs that were threefold higher than those obtained with egg-derived antigen in both the HI and neutralization tests and both antigens detected an equivalent number of fourfold titer rises in HI and neutralization tests. Sucrose gradient-fractionated egg-derived antigen showed a single peak of hemagglutinin activity corresponding to whole virions, whereas MDCK-derived antigen contained two distinct peaks of hemagglutinin activity, one of which had a lower sedimentation rate. The overall findings indicate that the egg-derived antigen in the vaccine induced HI and neutralizing antibody to both egg- and MDCK-derived variants and suggest that titers of antibody to MDCK-derived virus may be affected by the physical form of the hemagglutinin antigen.
Investigation of the Immunostimulatory Properties of Oxihumate

A unique process has been developed to convert bituminous coal by controlled wet oxidation followed by base treatment to a water-soluble humate called oxihumate. The effects of oxihumate on the proliferative response of lymphocytes has been studied in vitro and ex vivo. Oxihumate increased the proliferative response of phytohaemagglutinin-stimulated human lymphocytes, from a concentration of 20 μg/ml and upwards. This response was even more striking in the case of lymphocytes from HIV-infected patients and was not limited to the in vitro setting since similar effects were observed ex vivo following administration of a nontoxic dosage of 4 g oxihumate per day to HIV-positive individuals for two weeks. Mechanistic studies revealed that stimulation of the proliferative response of lymphocytes by oxihumate is associated with an increased production of IL-2, as well as expression of the IL-2 receptor in the setting of decreased production of IL-10. Oxihumate therefore holds promise for the treatment of immunocompromized patients.
Exploring controversy via sentiment divergences of aspects in reviews

A visual summary of the controversial aspects of an item enables both customers and marketers to identify and address complaints and concerns about the item effectively. In this paper, we propose a novel visual analytics system, to visually explore when a controversy occurs and the causes behind the controversy via user-generated reviews with text and ratings in various domains, such as restaurants, home goods, and cultural products. Quantitative analysis of the ratings of an item is first applied to characterize the evolution of controversy over time. A novel aspect-extraction method based on hierarchical clustering is proposed to identify aspect-level reasons garnered from review texts that explain why a controversy occurs. Our system allows the user to interactively explore the time-evolving controversy trend, major aspects of reviews, and sentiment divergences of aspects to understand in depth the controversy in reviews. We evaluate the effectiveness of the proposed aspect-extraction method by means of accuracy of aspect identification, the usefulness of our system using three case studies in different domains, and a user study.
How effective is our current Orthopaedic Prioritisation Tool for scoring patients for arthroplasty surgery?

AIM To compare those patients who are being accepted onto the waiting list for total hip and knee arthroplasty surgery with those patients who are being declined surgery, using a validated functional questionnaire. METHOD The clinic records from all patients seen for consideration of total hip or knee arthroplasty at Hawkes Bay Hospital during the preceding four months were reviewed. We sent the Oxford Hip and Knee Score questionnaire to all patients who had been put forward for consideration of surgery. RESULTS Of the 150 patients we surveyed, 81 had been accepted onto the waiting list and received a date for surgery within the next four months and 69 had been declined surgery. Of the 81 patients who had been accepted onto the waiting list for surgery, 61 returned the Oxford questionnaire with an average score of 10.9. Of the 69 patients who had been declined surgery, 59 returned the Oxford questionnaire with an average score of 10.8. Thus the mean Oxford score was not statistically different between those patients being accepted onto the waiting list for surgery and those being declined surgery (p=0.925). CONCLUSION No difference was found between those patients being accepted onto the waiting list for total hip or knee arthroplasty and those being declined surgery in Hawkes Bay after using the Oxford Hip and Knee Score as a measure of functional impairment. The average Oxford score indicates that patients being seen in Hawkes Bay Hospital for consideration of total hip or knee arthroplasty are severely functionally impaired as a result of their condition.
Metabolic syndrome and metabolic abnormalities in bipolar disorder: a meta-analysis of prevalence rates and moderators.

OBJECTIVE Patients with bipolar disorder have high levels of cardiovascular disease risk factors. The presence of metabolic syndrome significantly influences future cardiovascular disease morbidity and mortality. The authors sought to clarify the prevalence and moderators of metabolic syndrome in bipolar patients, accounting for subgroup differences. METHOD The authors searched MEDLINE, PsycINFO, EMBASE, and CINAHL through April 2012 for research reporting metabolic syndrome prevalence rates in bipolar patients. Medical subject headings "metabolic syndrome" and "bipolar" were used in the title, abstract, or index term fields. Manual searches were conducted using the reference lists from identified articles. RESULTS The search yielded 81 articles in 37 publications (N=6,983). The overall metabolic syndrome rate was 37.3% (95% confidence interval [CI]=36.1-39.0) using any standardized metabolic syndrome criteria. Compared with general population groups, bipolar patients had higher metabolic syndrome rates (odds ratio=1.98; 95% CI=1.74-2.25). In bipolar patients, older age had a modest effect on the metabolic syndrome rate. The strongest moderator was the region in which the study took place, with the highest rates observed in New Zealand and Australia (64.2% [95% CI=38.3-83.9]) and North America (49.3% [95% CI=29.7-69.3]). Metabolic syndrome was significantly more prevalent in patients currently treated with antipsychotics (45.3% [95% CI=39.6-50.9] than in patients who were antipsychotic free (32.4% [95% CI=27.5-37.4]; odds ratio=1.72 [95% CI=1.24-2.38]). CONCLUSIONS These findings strongly support the claim that patients with bipolar disorder are at high risk for metabolic syndrome and related cardiovascular morbidity and mortality and require regular monitoring and adequate preventive efforts and treatment for cardio-metabolic risk factors. These findings further suggest that the risk of metabolic syndrome is greater in bipolar patients taking prescribed antipsychotic medication.
Accumulation and release of nitrogen and phosphorus in relation to lignin decomposition in leaf litter of 14 tree species

Immobilization and mobilization of nitrogen and phosphorus were investigated in relation to the nitrogen (L/N) ratio and lignin to the phosphorus (L/P) ratio as indicators of the nitrogen and phosphorus dynamics. The present study was carried out on upper and lower parts of a forest slope in a cool temperate forest in Japan. Net immobilization and net mobilization characterized the dynamics of nitrogen and phosphorus in 14 litter types and were related to the changes in the L/N and L/P ratio. The critical values of the L/N and L/P ratio at which the mobilization began were 23–25 and 500–620, respectively. In litter types with the L/N and L/P ratio higher than critical values, nitrogen and phosphorus were immobilized until the ratios reached at the critical values and then nitrogen and phosphorus began decreasing. In litter types with initial L/N and L/P ratios lower than or equal to the critical values, nitrogen and phosphorus were released from litter. The critical values of the L/N and L/P ratios showed convergent trends among litter types as compared to their initial values, and were approached to those of underlying humus layers. These results indicated the usefulness of L/N and L/P ratios as indicators of the nitrogen and phosphorus dynamics in the study site. The general validity of the L/N ratio as an indicator of nitrogen dynamics and the convergent trend of critical L/N ratio at 25–30 were demonstrated by a review of literature on lignin and nitrogen dynamics in 47 litter types in temperate and boreal forests.
Environmental prevention of infection in stem cell transplant recipients: a survey of the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation

The developments of peripheral blood stem cells in autologous hematopoietic stem cell transplantation (auto‐HCT), and of reduced‐intensity conditioning (RIC) regimens in allogeneic HCT (allo‐HCT), have considerably changed the transplant approach. Prolonged neutropenia combined with severe mucosal damage and organ dysfunction is no longer the rule in the early post‐HCT pancytopenic phase. Although strict isolation during pancytopenia was followed by most HCT units in the past, this may not be the current practice.