Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of QTL for UV-Protective Eye Area Pigmentation in Cattle by Progeny Phenotyping and Genome-Wide Association Analysis

Pigmentation patterns allow for the differentiation of cattle breeds. A dominantly inherited white head is characteristic for animals of the Fleckvieh (FV) breed. However, a minority of the FV animals exhibits peculiar pigmentation surrounding the eyes (ambilateral circumocular pigmentation, ACOP). In areas where animals are exposed to increased solar ultraviolet radiation, ACOP is associated with a reduced susceptibility to bovine ocular squamous cell carcinoma (BOSCC, eye cancer). Eye cancer is the most prevalent malignant tumour affecting cattle. Selection for animals with ACOP rapidly reduces the incidence of BOSCC. To identify quantitative trait loci (QTL) underlying ACOP, we performed a genome-wide association study using 658,385 single nucleotide polymorphisms (SNPs). The study population consisted of 3579 bulls of the FV breed with a total of 320,186 progeny with phenotypes for ACOP. The proportion of progeny with ACOP was used as a quantitative trait with high heritability (h2 = 0.79). A variance component based approach to account for population stratification uncovered twelve QTL regions on seven chromosomes. The identified QTL point to MCM6, PAX3, ERBB3, KITLG, LEF1, DKK2, KIT, CRIM1, ATRN, GSDMC, MITF and NBEAL2 as underlying genes for eye area pigmentation in cattle. The twelve QTL regions explain 44.96% of the phenotypic variance of the proportion of daughters with ACOP. The chromosomes harbouring significantly associated SNPs account for 54.13% of the phenotypic variance, while another 19.51% of the phenotypic variance is attributable to chromosomes without identified QTL. Thus, the missing heritability amounts to 7% only. Our results support a polygenic inheritance pattern of ACOP in cattle and provide the basis for efficient genomic selection of animals that are less susceptible to serious eye diseases.
Evaluation of a subject on leadership and intrapersonal development: views of the students based on qualitative evaluation

Abstract “Tomorrow’s Leaders” is a subject developed to satisfy the leadership and intrapersonal development requirement at The Hong Kong Polytechnic University. After taking this subject, students were invited to use three descriptors and a metaphor to describe their experiences about the subject. Based on the reflections of 143 students, results showed that 94.4% of the descriptors used by informants were positive and 2.31% of the descriptors were negative. For the metaphors used to describe the subject, 92.7% were positive and 4.47% were negative. In conjunction with other findings, the present study suggests that Tomorrow’s Leaders is a subject that can promote the holistic development in Chinese university students in Hong Kong.
A critical review of analytical ultracentrifugation and field flow fractionation methods for measuring protein aggregation

Analytical ultracentrifugation (AUC) and field flow fractionation (FFF) are 2 important biophysical methods for measuring protein aggregates. Both methods can separate protein monomer from its aggregate forms under a broad range of solution conditions. Recent advances in instrumentation and data analysis, particularly in the field of analytical ultracentrifugation technology, have significantly improved the capability and sensitivity of these biophysical methods for detecting protein aggregates. These advances have resulted in an increased use of these methods in the biopharmaceutical industry for characterization of therapeutic proteins. However, despite their many advantages over conventional methods, the difficulty in the use of the instrumentation and the complexity of data analysis process, have often hampered the widespread use and proper interpretation of data. This article reviews the recent progress in both technologies, and a few case studies are also presented to discuss their advantages and limitations.
“I don't want to be near you, unless…”: The interactive effect of unethical behavior and performance onto relationship conflict and workplace ostracism

Examined through the lens of moral psychology, we investigate when and why employees’ unethical behaviors may be tolerated versus rejected. Specifically, we examine the interactive effect of employees’ unethical behaviors and job performance onto relationship conflict, and whether such conflict eventuates in workplace ostracism. Although employees’ unethical behaviors typically go against moral norms, high job performance may provide a motivated reason to ignore moral violations. In this regard, we predict that job performance will mitigate the relationship between employee unethical behavior and workplace ostracism, as mediated by relationship conflict. Study 1, a multisource field study, tests and provides support for Hypotheses 1 and 2. Study 2, also a multisource field study, provides support for our fully specified model. Study 3, a time-lagged field study, provides support for our theoretical model while controlling for employees’ negative affectivity and ethical environment. Theoretical and practical implications are discussed.
Relational semantics for effect-based program transformations with dynamic allocation

We give a denotational semantics to a region-based effect system tracking reading, writing and allocation in a higher-order language with dynamically allocated integer references. Effects are interpreted in terms of the preservation of certain binary relations on the store, parameterized by region-indexed partial bijections on locations. The semantics validates a number of effect-dependent program equivalences and can thus serve as a foundation for effect-based compiler transformations.
Temporally-independent functional modes of spontaneous brain activity

Resting-state functional magnetic resonance imaging has become a powerful tool for the study of functional networks in the brain. Even “at rest,” the brain's different functional networks spontaneously fluctuate in their activity level; each network's spatial extent can therefore be mapped by finding temporal correlations between its different subregions. Current correlation-based approaches measure the average functional connectivity between regions, but this average is less meaningful for regions that are part of multiple networks; one ideally wants a network model that explicitly allows overlap, for example, allowing a region's activity pattern to reflect one network's activity some of the time, and another network's activity at other times. However, even those approaches that do allow overlap have often maximized mutual spatial independence, which may be suboptimal if distinct networks have significant overlap. In this work, we identify functionally distinct networks by virtue of their temporal independence, taking advantage of the additional temporal richness available via improvements in functional magnetic resonance imaging sampling rate. We identify multiple “temporal functional modes,” including several that subdivide the default-mode network (and the regions anticorrelated with it) into several functionally distinct, spatially overlapping, networks, each with its own pattern of correlations and anticorrelations. These functionally distinct modes of spontaneous brain activity are, in general, quite different from resting-state networks previously reported, and may have greater biological interpretability.
Portraits of individuals with dementia: views of care managers

It can be very difficult to get to know a person with late-stage dementia. This is especially true for staff that work in care homes with little time to spend with each resident and even less to focus on social interaction. This paper presents a software tool that was created to help care staff become more familiar with a person with dementia in a limited timeframe. A study was conducted with three care home managers to collect initial response, usefulness and usability ratings of the software in a care home environment. The participants responded positively to the software finding it engaging and very relevant to a care home environment
Information Cascades in the Laboratory

When a series of individuals with private information announce public predictions, initial conformity can create an 'information cascade' in which later predictions match the early announcements. This paper reports an experiment in which private signals are draws from an unobserved urn. Subjects make predictions in sequence and are paid if they correctly guess which of two urns was used for the draws. If initial decisions coincide, then it is rational for subsequent decisionmakers to follow the established pattern, regardless of their private information. Rational cascades formed in most periods in which such an imbalance occurred. Copyright 1997 by American Economic Association.
Interpersonal Relationships: Exploring Race and Relationship Decisions Among African American College Men

This study explores how race influenced African American men’s interpersonal relationships with other men at a predominantly White institution. The use of both semi-structured and photo-elicitation interview formats provided participants an opportunity to reflect on their precollege experiences, identity, and relationships. Two categories emerged during data analysis: (a) racial diversity of hometown and relationship formation, and (b) environmental influences on racial identity and decisions about relationships. Implications for future research and practice are offered.
Hyper Video Browser: Search and Hyperlinking in Broadcast Media

Massive amounts of digital media is being produced and consumed daily on the Internet. Efficient access to relevant information is of key importance in contemporary society. The Hyper Video Browser provides multiple navigation means within the content of a media repository. Our system utilizes the state of the art multimodal content analysis and indexing techniques, at multiple temporal granularity, in order to satisfy the user need by suggesting relevant material. We integrate two intuitive interfaces: for search and browsing through the video archive, and for further hyperlinking to the related content while enjoying some video content. The novelty of this work includes a multi-faceted search and browsing interface for navigating in video collections and the dynamic suggestion of hyperlinks related to a media fragment content, rather than the entire video, being viewed. The approach was evaluated on the MediaEval Search and Hyperlinking task, demonstrating its effectiveness at locating accurately relevant content in a big media archive.
Context-dependent metabolic networks

Cells adapt their metabolism to survive changes in their environment. We present a framework for the construction and analysis of metabolic reaction networks that can be tailored to reflect different environmental conditions. Using context-dependent flux distributions from Flux Balance Analysis (FBA), we produce directed networks with weighted links representing the amount of metabolite flowing from a source reaction to a target reaction per unit time. Such networks are analyzed with tools from network theory to reveal salient features of metabolite flows in each biological context. We illustrate our approach with the directed network of the central carbon metabolism of Escherichia coli, and study its properties in four relevant biological scenarios. Our results show that both flow and network structure depend drastically on the environment: networks produced from the same metabolic model in different contexts have different edges, components, and flow communities, capturing the biological re-routing of metabolic flows inside the cell. By integrating FBA-based analysis with tools from network science, our results provide a framework to interrogate cellular metabolism beyond standard pathway descriptions that are blind to the environmental context.
The changing logic of political citizenship : Cross-national acquisition of women's suffrage rights, 1890 to 1990

The authors analyze the acquisition of women's suffrage in 133 countries from 1890 to 1990. Throughout the twentieth century the influence of national political and organizational factors has declined and the importance of international links and influences has become increasingly important. These findings indicate that the franchise has become institutionalized worldwide as a taken-for-granted feature of national citizenship and an integral component of Nation-State identity : the prevailing model of political citizenship has become more inclusive
Exploring usefulness of video-based instruction as a pedagogical tool in learning of Mathematics

1 Mathematics Education Department, Mauritius Institute of Education, Reduit, MAURITIUS __________________________________________________________________________________________ Abstract: In this study, we examined the use of videos as a pedagogical tool in mathematics lessons at O-level (age 15-16 years). A case study of a class of 29 students from a low-performing school was considered. The content of the videos were leaned on the prior knowledge of the students and we provide a study of a set of five videos prepared on the topic Locus which embodied progressive and interlinking quizzes, worked examples and class activities. Each lesson was video recorded for grasping the classroom dynamism. We found that constructive classroom interaction hinged on the videos encouraged the low-performing students to participate thereby enhancing socio-pedagogical interactions in the class. Carefully chosen stop points of the videos greatly enhanced students’ attention and focus. Moreover, small-group questioning and discussion strategies maintained students’ interest, enthusiasm and motivation. The majority of the students found the videos interesting and helpful in retaining more information and improving their understanding of Loci. Assessment worksheets and quizzes evidenced an improvement in their performances. The study establishes that carefully created educational videos in mathematics can provide better learning opportunities and can mediate gainful knowledge construction among students.
Short-Run Advertising Effects on Children: A Field Study

Most evidence concerning the impact of television commercials on children has been derived from anecdotal reports [1] or from studies in which the dependent measures have been cognitive or attitudinal rather than behavioral [e.g., 6]. The exceptions are two recent experimental studies which have demonstrated that commercials can have a significant effect on children's behavioral choices in a laboratory setting [3, 5]. The present study examines the effectiveness of children's commercials in a field setting. Changes in children's toy and game choices were measured during the Christmas toy and game advertising campaign of November-December 1972. In the immediate pre-Christmas months, toy and game commercials constituted more than 50% of the advertising on children's television programs [2]. Whereas the usually predominant food and beverage advertising is spread throughout the year, half of the total volume of children's toy and game advertising is presented in November and December. This advertising concentration permits a naturalistic setting for a beforeand-after study of children's toy and game choices.
TESTING ADAPTIVE RADIATION AND KEY INNOVATION HYPOTHESES IN SPIDERS

We combine statistical and phylogenetic approaches to test the hypothesis that adaptive radiation and key innovation have contributed to the diversity of the order Araneae. The number of unbalanced araneid clades (those whose species numbers differ by 90% or more) exceeds the number predicted by a null Markovian model. The current phylogeny of spider families contains 74 bifurcating nodes, of which 31 are unbalanced. As this is significantly more than the 14.8 expected unbalanced nodes, some of the diversity within the Araneae can be attributed to some deterministic cause (e.g., adaptive radiation). One of the more highly unbalanced (97%) bifurcations divides the orb‐weaving spiders into the Deinopoidea and the larger Araneoidea. A simple statistical model shows that the inequality in diversity between the Deinopoidea and the Araneoidea is significant, and that it is associated with the replacement of primitive cribellar capture thread by viscous adhesive thread and a change from a horizontal to a vertical orb‐web orientation. These changes improve an orb‐web's ability to intercept and retain prey and expand the adaptive zone that orb‐weaving spiders can occupy and are, therefore, considered to be “key innovations. ”
Identification of Proteins Related to Nickel Homeostasis in Helicobater pylori by Immobilized Metal Affinity Chromatography and Two-Dimensional Gel Electrophoresis

Helicobacter pylori (H. pylori) is a widespread human pathogen causing peptic ulcers and chronic gastritis. Maintaining nickel homeostasis is crucial for the establishment of H. pylori infection in humans. We used immobilized-nickel affinity chromatography to isolate Ni-related proteins from H. pylori cell extracts. Two-dimensional gel electrophoresis and mass spectrometry were employed to separate and identify twenty two Ni-interacting proteins in H. pylori. These Ni-interacting proteins can be classified into several general functional categories, including cellular processes (HspA, HspB, TsaA, and NapA), enzymes (Urease, Fumarase, GuaB, Cad, PPase, and DmpI), membrane-associated proteins (OM jhp1427 and HpaA), iron storage protein (Pfr), and hypothetical proteins (HP0271, HP jhp0216, HP jhp0301, HP0721, HP0614, and HP jhp0118). The implication of these proteins in nickel homeostasis is discussed.
Multiple Sector ID Capture (MIDC): A Novel Beamforming Technique for 60-GHz Band Multi-Gbps WLAN/PAN Systems

A novel beamforming (BF) technique (MIDC: Multiple sector-ID Capture) is proposed for 60-GHz band WLAN/PAN systems. In contrast to conventional BF techniques adopted in 60-GHz band standards, where quasi-omni (Q-omni) antenna radiation patterns are utilized, MIDC precisely detects the best link even when the Q-omni pattern is imperfect. Furthermore, it can reserve multiple antenna settings corresponding to existing communication links in the initial training by making use of the quasi-optical nature of millimeter-waves. This enables fast beam switching when link blockage occurs. The training is executed in short durations by putting together DoA/DoD-estimation and “beam-combining” techniques. The basic function of MIDC is verified experimentally in a simple multipath propagation environment by using our 60-GHz CMOS transceiver LSIs integrated with planar phased-array antennas. MIDC has been adopted in the MAC/PHY specification of the primary 60-GHz band standards: WiGig (Wireless Gigabit Alliance) and IEEE 802.11ad.
MBD1 and MeCP2 expression in embryos and placentas from transgenic cloned goats

Summary DNA methylation is an important form of epigenetic regulation in mammalian development. Methyl-CpG-binding domain protein 1 (MBD1) and methyl-CpG-binding domain protein 2 (MeCP2) are two members of the MBD subfamily of proteins that bind methylated CpG to maintain the silencing effect of DNA methylation. Given their important roles in linking DNA methylation with gene silencing, this study characterized the coordinated mRNA expression and protein localization of MBD1 and MeCP2 in embryos and placentas and aimed to analysis the effects of MBD1 and MeCP2 on transgenic cloned goats. Our result showed that MBD1 expression of transgenic cloned embryo increased significantly at the 2–4-cell and 8–16-cell stages (P < 0.05), then decreased at the morula and blastocyst stages (P < 0.05); MeCP2 expression in transgenic cloned embryo was significant decreased at the 2–4-cell stage and increased at the 8–16-cell stage (P < 0.05). Placenta morphology analysis showed that the cotyledon number of deceased transgenic cloned group (DTCG) was significantly lower than that the normal goats (NG) and in the live transgenic cloned goats (LTCG) (P < 0.05). MBD1 and MeCP2 were clearly detectable in the placental trophoblastic binucleate cells by immunohistochemical staining. Moreover, MBD1 and MeCP2 expression in DTCG was significant higher than in the NG and the LTCG (P < 0.05). In summary, aberrant expression of methylation CpG binding proteins MBD1 and MeCP2 was detected in embryonic and placental development, which reflected abnormal transcription regulation and DNA methylation involved in MBD1 and MeCP2. These findings have implications in understanding the low efficiency of transgenic cloning.
ABC-EP: Expectation Propagation for Likelihoodfree Bayesian Computation

Many statistical models of interest to the natural and social sciences have no tractable likelihood function. Until recently, Bayesian inference for such models was thought in-feasible. Pritchard et al. (1999) introduced an algorithm known as ABC, for Approximate Bayesian Computation, that enables Bayesian computation in such models. Despite steady progress since this first breakthrough, such as the adaptation of MCMC and Sequential Monte Carlo techniques to likelihood-free inference, state-of-the art methods remain hard to use and require enormous computation times. Among other issues, one faces the difficult task of finding appropriate summary statistics for the model, and tuning the algorithm can be time-consuming when little prior information is available. We show that Expectation Propagation, a widely successful approximate inference technique, can be adapted to the likelihood-free context. The resulting algorithm does not require summary statistics, is an order of magnitude faster than existing techniques, and remains usable when prior information is vague.
A Generic Checkpoint-Restart Mechanism for Virtual Machines

It is common today to deploy complex software inside a virtual machine (VM). Snapshots provide rapid deployment, migration between hosts, dependability (fault tolerance), and security (insulating a guest VM from the host). Yet, for each virtual machine, the code for snapshots is laboriously developed on a per-VM basis. This work demonstrates a generic checkpoint-restart mechanism for virtual machines. The mechanism is based on a plugin on top of an unmodified user-space checkpoint-restart package, DMTCP. Checkpoint-restart is demonstrated for three virtual machines: Lguest, user-space QEMU, and KVM/QEMU. The plugins for Lguest and KVM/QEMU require just 200 lines of code. The Lguest kernel driver API is augmented by 40 lines of code. DMTCP checkpoints user-space QEMU without any new code. KVM/QEMU, user-space QEMU, and DMTCP need no modification. The design benefits from other DMTCP features and plugins. Experiments demonstrate checkpoint and restart in 0.2 seconds using forked checkpointing, mmap-based fast-restart, and incremental Btrfs-based snapshots.