Miracle-dz/UniFAR-FTUs huggingface dataset:
A Two-Population Evolutionary Algorithm for Constrained Optimization Problems

A new approach to solving constrained nonlinear programming problems using evolutionary computations is discussed. According to the method two populations are evolved, one population (females) is evolved inside the feasible domain of the design space and a second population (males) is evolved outside this feasible domain. Both populations can be independently subject to crossover and mutation operations and the design space explored. Female-male crossover however ensures the desirable increase in the search pressure upon the boundaries of the feasible space -it is known that in many optimization problems the global optimum is bounded. The experiments performed on three test objective functions of two variables show some promise of the proposed approach in that it can cope with both linear and nonlinear constraints and with nonconvex feasible domains.
Bayesian Pronoun Interpretation in Mandarin Chinese

Kehler and Rohde (2013) proposed a Bayesian theory of pronoun interpretation where the influence of world knowledge emerges as effects on the prior and the influence of information structure as effects on the likelihood: P(referent|pronoun) μ P(pronoun|referent)P(referent). Here we present two experiments on Mandarin Chinese that allow us to test the generality of the theory for a language with different syntactic-semantic associations than English. Manipulations involving two different classes of implicit-causality verbs and passive vs. active voice confirmed key predictions of the Bayesian theory: effects of these manipulations on the prior and likelihood in production were consistently reflected in pronoun interpretation preferences. Quantitative analysis shows that the Bayesian model is the best fit for Mandarin compared to two competing analyses. These results lend both qualitative and quantitative support to a cross linguistically general Bayesian theory of pronoun interpretation.
Src promotes castration-recurrent prostate cancer through androgen receptor-dependent canonical and non-canonical transcriptional signatures

Progression of prostate cancer (PC) to castration-recurrent growth (CRPC) remains dependent on sustained expression and transcriptional activity of the androgen receptor (AR). A major mechanism contributing to CRPC progression is through the direct phosphorylation and activation of AR by Src-family (SFK) and ACK1 tyrosine kinases. However, the AR-dependent transcriptional networks activated by Src during CRPC progression have not been elucidated. Here, we show that activated Src (Src527F) induces androgen-independent growth in human LNCaP cells, concomitant with its ability to induce proliferation/survival genes normally induced by dihydrotestosterone (DHT) in androgen-dependent LNCaP and VCaP cells. Src induces additional gene signatures unique to CRPC cell lines, LNCaP-C4-2 and CWR22Rv1, and to CRPC LuCaP35.1 xenografts. By comparing the Src-induced AR-cistrome and/or transcriptome in LNCaP to those in CRPC and LuCaP35.1 tumors, we identified an 11-gene Src-regulated CRPC signature consisting of AR-dependent, AR binding site (ARBS)-associated genes whose expression is altered by DHT in LNCaP[Src527F] but not in LNCaP cells. The differential expression of a subset (DPP4, BCAT1, CNTNAP4, CDH3) correlates with earlier PC metastasis onset and poorer survival, with the expression of BCAT1 required for Src-induced androgen-independent proliferation. Lastly, Src enhances AR binding to non-canonical ARBS enriched for FOXO1, TOP2B and ZNF217 binding motifs; cooperative AR/TOP2B binding to a non-canonical ARBS was both Src- and DHT-sensitive and correlated with increased levels of Src-induced phosphotyrosyl-TOP2B. These data suggest that CRPC progression is facilitated via Src-induced sensitization of AR to intracrine androgen levels, resulting in the engagement of canonical and non-canonical ARBS-dependent gene signatures.
Challenges to ES Success : A Critical Need for Knowledge Integration

Recent literature on Enterprise System (ES) implementation projects highlights the importance of Knowledge Integration (KI) for implementation success. The fundamental characteristics of ES - integration of modules, business process view, and aspects of information transparency - necessitate that all frequent end-users share a reasonable amount of common knowledge and integrate their knowledge to yield new knowledge. Unfortunately, the importance of KI is often overlooked and little about the role of KI in ES success is known. In this chapter, the authors study the KI impact on ES success that is relevant to the ES post-implementation in support of organizations' returns on their ES investments. They adopt the ES post-implementation segment of ES utilization to explore whether the KI approach is causally linked to ES success. The research model was tested in a multi-industry sample in Malaysia from which data was gathered from managerial and operational employees spread across six large organizations. Consistent with the explanation by knowledge-based theory, the results show that KI was valid and significantly related to the outcome of ES that relates to an organization's performance, which the authors refer to as ES success. The KI positive impact on the success of ES drives one to highlight the importance of ontological KI in the complexity of the ES environment. The authors believe that focusing on an ontology through the KI perspective can make significant contributions to current ES problems.
Optimization of Predicted Portfolio Using Various Autoregressive Neural Networks

This work presents a neural networks approach for stock returns and uses mean-variance model for the selection of predicted portfolio thus formed. Four types of different neural network models have been used and their outputs have been compared at various regression orders. A new type of predictor called autoregressive moving reference neural network predictor has been used in all the four neural network models. In this predictor the differences between the values of the series of returns and a determined past value are the regression variables. To evaluate the performance of the predictor, various error measures have been used, taking the average of these error measures, the overall performance of the predictor has been tested. Experiments with real data from National stock exchange of India (NSE) were employed to examine the accuracy of this method.
Diagnosis and Quantitative Assessment of Mandibular Asymmetry Using CBCT Image Volumes

Objective: To determine if 3D shape correspondence can accurately quantify mandibular asymmetry in surgical patients. Methods: Pretreatment cone-Beam CT scans were acquired of twenty orthognathic surgery patients with different degrees and types of facial asymmetry. The maxillofacial hard tissues were segmented and mirroring was performed for virtual surgical planning using the CranioMaxilloFacial Application software. Mirrored surgical models were superimposed on the actual patient models using two different approaches: (1) mirroring on the midsagittal plane; and (2) mirroring on an arbitrary plane with registration on the cranial base. Different amounts of additional mandibular asymmetry in the three planes of space were simulated by known amounts. For both mirroring methods, SPHARM shape correspondence was used to detect and quantify simulated asymmetries. Results SPHARM-shape correspondence accurately quantified different types and degrees of virtually simulated facial asymmetry. The probabilities for all 6 degrees of freedom ( rotation and translation) that the difference between asymmetry measurements and the known virtually simulated value is less than 0.5mm was very good for both mirroring techniques
Centrosomal association of histone macroH2A1.2 in embryonic stem cells and somatic cells.

The histone 2A variant macroH2A1.2 is expressed in female and male mammals and is implicated in X-chromosome inactivation and autosomal gene silencing. In undifferentiated and early differentiating murine embryonic stem (ES) cells a cytosolic pool of macroH2A1.2 has recently been reported and found to be associated with the centrosome. Here, we show that the centrosomal association of macroH2A1.2 is a widespread phenomenon and is not restricted to undifferentiated and early differentiating ES cells. By indirect immunofluorescence we detect macroH2A1.2 protein in a juxtanuclear structure that duplicates once per cell cycle and colocalizes with centrosomal gamma-tubulin in both XX and XY ES cells prior to and throughout their differentiation. MacroH2A1.2 localization to the centrosome is also observed in female and male somatic cells, both in interphase and in mitosis. Biochemical analysis demonstrates that the association between macroH2A1.2 and the centrosome in somatic cells is stable, as macroH2A1.2 copurifies with centrosomes isolated from human lymphoblasts. Therefore, in addition to a nuclear pool of macroH2A1.2 a fraction of the histone is associated with the centrosome in various cell types and throughout ES cell differentiation.
Relations Versus Functions at the Foundations of Logic: Type-Theoretic Considerations

Though Frege was interested primarily in reducing mathematics to logic, he succeeded in reducing an important part of logic to mathematics by defining relations in terms of functions. In contrast, Whitehead and Russell reduced an important part of mathematics to logic by defining functions in terms of relations (using the definite description operator). We argue that there is a reason to prefer Whitehead and Russell’s reduction of functions to relations over Frege’s reduction of relations to functions. There is an interesting system having a logic that can be properly characterized in relational type theory (RTT) but not in functional type theory (FTT). This shows that RTT is more general than FTT. The simplification offered by Church in his FTT is an over-simplification: one cannot assimilate predication to functional application.
Substantial stream-disc overflow found in three-dimensional SPH simulations of cataclysmic variables

We study numerically the interaction of the infalling gas stream and the rim of the accretion disc in cataclysmic variables. The simulations were performed with a smoothed particle hydrodynamics scheme with high spatial resolution. Parameters of the systems AM CVn, OY Car, DQ Her, U Gem and IP Peg were used for the simulations. The simulations cover a wide range of orbital periods, mass ratios and mass transfer rates, as well as different thermal states of the accretion disc. The main result of this study is that the accretion stream is not stopped at the impact region (the bright spot at the outer rim of the disc). In fact, after undergoing the shock interaction, most of the matter is deflected vertically and flows in a more or less diffuse stream to inner parts of the disc, hitting the disc surface close to the circularization radius at orbital phase 0.5. This is a common feature in all systems for all simulated parameters. This stream overflow can cause the X-ray absorption dips observed in cataclysmic variables (CVs) and low-mass X-ray binaries (LMXBs) around orbital phase 0.7, if the inclination is at least 65°. Under certain circumstances, namely a sudden increase of the mass transfer rate from the secondary or a rather small disc, parts of the overflowing stream bounce off the disc surface after hitting it at orbital phase ≈0.5. Another absorption region can be expected around orbital phase 0.2. In our simulations most of the infalling matter reaches the inner disc very quickly. This must alter the evolution of the quiescent disc and the outburst behaviour considerably compared with purely viscous transport of the material through the disc from the outer rim, and therefore should be taken into account in dwarf nova outburst cycle calculations. To our knowledge, the consequences of such a massive stream overflow for the dwarf nova outburst cycle have not been considered yet.
Comparison of scaffold-enhanced albumin and n-butyl-cyanoacrylate adhesives for joining of tissue in a porcine model

An ex vivo study was conducted to compare the tensile strength of tissue samples repaired using three different techniques: (i) application of a scaffold-enhanced light-activated albumin protein solder, (ii) application of a scaffold-enhanced n-butyl-cyanoacrylate adhesive, and (iii) repair via conventional suture technique. Biodegradable polymer scaffolds of controlled porosity were fabricated with poly(L-lactic-co-glycolic acid) and salt particles using a solvent-casting and particulate-leaching technique. Group I porous scaffolds were doped with protein solder composed of 50%(w/v) bovine serum albumin solder and 0.5mg/ml indocyanine green dye mixed in deionized water, and activated with an 808-nm diode laser. Group II scaffolds were doped with n-butyl-cyanoacrylate, and required no light-activation. No stay sutures were required for Group I or II experiments. Group III repairs were performed using a single 4-0 suture. Thirteen organs were tested ranging from skin to liver to the small intestine, as well as the coronary, pulmonary, carotid, femoral and splenic arteries. Acute breaking strengths were measured and the data were analyzed by Student’s T-test. Using the protein solder of Group I, repairs formed on the ureter were most successful followed by small intestine, sciatic nerve, spleen, atrium, kidney, muscle, skin and ventricle. The strongest vascular repairs were achieved in the carotid artery and femoral artery. Overall, the tensile strength of Group III repairs performed via suture techniques were equivalent in magnitude to that of Group I repairs, however, a larger variance was observed in the suture repair group. Group II repairs utilizing the cyanoacrylate-doped scaffold all performed extremely well. Bonds formed using the Group II adhesive were approximately 30% stronger than Group I and III organ repairs and approximately 20% stronger than Group I and III vascular repairs. Application of the polymer scaffold assists in tissue alignment and reduces problems associated with adhesive runaway from the repair site. Scaffold-enhanced adhesives could possibly be used as a simple and effective method to join tissue together quickly and effectively in an emergency situation, or as a substitute to mechanical sutures or staples in many clinical applications.
A four command BCI system based on the SSVEP protocol

This paper discusses the development of a four command BCI system. This system is composed of a wearable electroencephalogram acquisition unit interfaced to a computer by a wireless Bluetoothreg (BT) connection. The implemented system relies on the steady-state visual evoked potential (SSVEP) protocol applied to a four selection system. In order to achieve the maximum reliability against false positives a five class classifier was used considering the idle state as an independent class. In order to maximize the usability of the system a two channel solution was tested and adopted. The BCI algorithm was based on a supervised multi-class classifier implemented by combining different binary regularized linear discriminant analysis (RLDA) classifiers. The biofeedback was evaluated by combining the resultant time signed distance with quality index related to the number of coherent identification obtained with the one-vs-all approach
Computational models of social and emotional turn-taking for embodied conversational agents: a review

The emotional involvement of participants in a conversation not only shows in the words they speak and in the way they speak and gesture but also in their turn-taking behavior. This paper reviews research into computational models of embodied conversational agents. We focus on models for turn-taking management and (social) emotions. We are particularly interested in how in these models emotions of the agent itself and those of the others in uence the agent's turn-taking behavior and vice versa how turn-taking behavior of the partner is perceived by the agent itself. The system of turn-taking rules presented by Sacks, Schegloff and Jefferson (1974) is often a starting point for computational turn-taking models of conversational agents. But emotions have their own rules besides the "one-at-a-time" paradigm of the SSJ system. It turns out that almost without exception computational models of turn-taking behavior that allow "continuous interaction" and "natural turntaking" do not model the underlying psychological, affective, attentional and cognitive processes. They are restricted to rules in terms of a number of supercially observable cues. On the other hand computational models for virtual humans that are based on a functional theory of social emotion do not contain explicit rules on how social emotions affect turn-taking behavior or how the emotional state of the agent is affected by turn-taking behavior of its interlocutors. We conclude with some preliminary ideas on what an architecture for emotional turn-taking should look like and we discuss the challenges in building believable emotional turn-taking agents.
Grid map establishment and target tracking based on adaptive multi-feature matching method

In this paper, we present an adaptive multi-feature matching method for target detection and target tracking based on an occupancy grid map in dynamic outdoor environments on a moving vehicle equipped with laser radar. The raw scanning points are divided into blocks and the matching strategy of ICP (Iterated Closest Points) algorithm is modified by using the multi-feature information of objects. We introduce a method to adaptively correct the weighting coefficients of the multi-feature in the similarity function. After matching the objects in the two adjacent frames, the online grid map is updated by Bayesian theory and the probability of inverse sensor model. The moving objects are detected with grid map matching. Then, the moving targets are finally tracked by tracker management coupled with Kalman filter. In the experiment, the online grid map is established and the stable results for targets tracking are also achieved.
Peer-to-Peer Service Sharing Platforms: Driving Share and Share Alike on a Mass-Scale

The sharing economy has been growing continuously in the last decade thanks to the proliferation of internet-based platforms that allow people to disintermediate the traditional commercial channels and to share excess resources and trade with one another effectively at a reasonably low transaction cost. Whereas early peer-to-peer platforms were designed to enable file sharing and goods trading, we recently witness the emergence of a new breed of peer-to-peer platforms that are designed for ordinary service sharing. Ordinary services entail intangible provisions and are defined as an economic activity that generates immaterial benefits and does not result in ownership of material goods. Based on a structured analysis of 41 internet-based rideshare platforms, we explore and layout the unique characteristics of peer-to-peer service sharing platforms based on three distinct temporal patterns that entail specific consequences for platform use as well as provide insights about their overall design imperative.
The 2012/2013 ABRF Proteomic Research Group Study: Assessing Longitudinal Intralaboratory Variability in Routine Peptide Liquid Chromatography Tandem Mass Spectrometry Analyses*

Questions concerning longitudinal data quality and reproducibility of proteomic laboratories spurred the Protein Research Group of the Association of Biomolecular Resource Facilities (ABRF-PRG) to design a study to systematically assess the reproducibility of proteomic laboratories over an extended period of time. Developed as an open study, initially 64 participants were recruited from the broader mass spectrometry community to analyze provided aliquots of a six bovine protein tryptic digest mixture every month for a period of nine months. Data were uploaded to a central repository, and the operators answered an accompanying survey. Ultimately, 45 laboratories submitted a minimum of eight LC-MSMS raw data files collected in data-dependent acquisition (DDA) mode. No standard operating procedures were enforced; rather the participants were encouraged to analyze the samples according to usual practices in the laboratory. Unlike previous studies, this investigation was not designed to compare laboratories or instrument configuration, but rather to assess the temporal intralaboratory reproducibility. The outcome of the study was reassuring with 80% of the participating laboratories performing analyses at a medium to high level of reproducibility and quality over the 9-month period. For the groups that had one or more outlying experiments, the major contributing factor that correlated to the survey data was the performance of preventative maintenance prior to the LC-MSMS analyses. Thus, the Protein Research Group of the Association of Biomolecular Resource Facilities recommends that laboratories closely scrutinize the quality control data following such events. Additionally, improved quality control recording is imperative. This longitudinal study provides evidence that mass spectrometry-based proteomics is reproducible. When quality control measures are strictly adhered to, such reproducibility is comparable among many disparate groups. Data from the study are available via ProteomeXchange under the accession code PXD002114.
A survey on ontology-driven geographic information systems

Geographic Information Systems (GIS) have become widely used for capturing, storing, integrating, analyzing and displaying various types of geospatial data. They have been applied to several fields such as transportation, education, business, tourism, urban planning, etc. Nowadays, with the advancement of GIS technological tools in capturing and storing geographic data, it leads to the challenge in managing data from diverse sources and storing in different formats at different levels of detail. In another word, two or more applications sharing data that represent the same thing may cause different types of heterogeneity problems. To enable GIS interoperability and data management, ontologies which are considered as powerful tools for information sharing, information processing and information integration are utilized in this context. This paper discusses how ontologies can be employed to resolve heterogeneities in order to enhance interoperability and support geospatial data sharing and reuse as well as facilitate decision making in GIS domain.
Ligand-1 on Human P-selectin Glycoprotein Synthesis of the Leukocyte Selectin Ligand ST 6 GalNAc-transferase Regulates the GlcNAc-transferase and Competition between Core-2 Glycobiology and Extracellular Matrices :

10.1074/jbc.M113.463653 Access the most updated version of this article at doi: . JBC Affinity Sites Find articles, minireviews, Reflections and Classics on similar topics on the Alerts: When a correction for this article is posted • When this article is cited • to choose from all of JBC's e-mail alerts Click here Supplemental material: http://www.jbc. org/content/suppl/2013/04/02/M113.463653. DC1.html
Mixing actions of the rationals

We study mixing properties of algebraic actions of $\mathbb Q^d$, showing in particular that prime mixing $\mathbb Q^d$ actions on connected groups are mixing of all orders, as is the case for $\mathbb Z^d$-actions. This is shown using a uniform result on the solution of $S$-unit equations in characteristic zero fields due to Evertse, Schlickewei and W. Schmidt. In contrast, algebraic actions of the much larger group $\mathbb Q^*$ are shown to behave quite differently, with finite order of mixing possible on connected groups.