Miracle-dz/UniFAR-FTUs huggingface dataset:
Recommendations : applicability to digestive tract cancer in Japan

Objectives: This paper reviewed analytic epidemiological studies of the major Japanese digestive tract cancers, i.e. esophageal, stomach, colon and rectal. The applicability of the recommendations for prevention of these cancers by the World Cancer Research Fund/American Institute of Cancer Research (W&A) to Japan is considered. Methods: Papers were searched by the MEDLINE for the period 1966 through 1997. Among them, 43 relevant papers including data from Japan were reviewed. Results: Results for 11 lifestyle-related factors were considered. Cigarette smoking was a strong and consistent, thus, convincing, risk factor for esophageal cancer, and a possible risk factor for stomach and colorectal cancer. Excessive consumption of alcohol was a convincing risk factor for esophageal cancer, and a possible risk factor for stomach and colorectal cancer. Excessive salt intake was a risk factor supported by some strong evidence but inconsistent; therefore, it is a probable risk factor for stomach cancer and a possible risk factor for colorectal cancer. Low physical activity was a probable risk factor for colorectal cancer. On the other hand, sucient intake of vegetables, including green±yellow vegetables, and fruits was regarded as a possible protective factor for these cancers. Conclusions: These observations were mostly consistent with those reported by W&A; therefore the recommendations by W&A for prevention of these cancers may be considered applicable to the current Japanese population.
Designing persistent heap for byte addressable NVRAM

NVRAM, such as STT-MRAM and 3D XPoint, enables persistent heap to replace existing file systems for data persistence. The persistent heap can eliminate the overhead of serializing the data structure into the file address space by granting persistence to the data structure. In this paper, we defined a persistent object store for persistent heap, and developed a namespace and persistent object management scheme for persistent object store. The persistent heap technique can impose a burden on the user, such as the use of an interface for a persistent object and consideration of a persistent object that becomes garbage. We developed a code regenerator, garbage collection, software transactional memory-based key value library and swapping technique for persistent heap to eliminate the burden that a user may experience when using persistent heap.
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY INVESTIGATIONS ON THE CRUDE EXTRACTS OF BRUCEA ANTIDYSENTERICA LEAVES

The aim of this study was to screen various solvent extracts of Brucea antidysenterica leaf to display potent antioxidant activity in vitro, total phenolic and flavonoid contents in order to find possible sources for future novel antioxidant activity in pharmaceutical formulations. Phytochemical screening showed the presence of alkaloids, flavonoids, phenols, Saponins, triterpenoids and steroids in large amounts in 80% methanol crude extract. The results revealed that the aqueous soluble fraction exhibited the highest percent inhibition (87.57 ± 1.15 %) of the DPPH radical as compared to the other fractions and crude extracts. It also showed the highest FRAP value (72.40 ± 0.22 mg AAE/g of fraction). The various crude extracts and fractions of Brucea antidysntrica significantly had antioxidant power and reduced the DPPH. Leaf of Brucea antidysenterica can be used as source of natural antioxidant and a potential alternative medicine for oxidative stress related to non-communicable chronic diseases associated with free radical and antibacterial activity.
C O ] 1 6 M ay 2 01 0 DISCRETE MORSE THEORY FOR TOTALLY NON-NEGATIVE FLAG VARIETIES KONSTANZE RIETSCH

In a seminal 1994 paper [26], Lusztig extended the theory of total positivity by introducing the totally non-negative part (G/P )≥0 of an arbitrary (generalized, partial) flag variety G/P . He referred to this space as a “remarkable polyhedral subspace,” and conjectured a decomposition into cells, which was subsequently proven by the first author [33]. In [40] the second author made the concrete conjecture that this cell decomposed space is the next best thing to a polyhedron, by conjecturing it to be a regular CW complex that is homeomorphic to a closed ball. In this article we use discrete Morse theory to prove this conjecture up to homotopy-equivalence. Explicitly, we prove that the boundaries of the cells are homotopic to spheres, and the closures of cells are contractible. The latter part generalizes a result of Lusztig’s [27], that (G/P )≥0 – the closure of the top-dimensional cell – is contractible. Concerning our result on the boundaries of cells, even the special case that the boundary of the top-dimensional cell (G/P )>0 is homotopic to a sphere, is new for all G/P other than projective space.
Viral Metagenomics on Animals as a Tool for the Detection of Zoonoses Prior to Human Infection?

Many human viral infections have a zoonotic, i.e., wild or domestic animal, origin. Several zoonotic viruses are transmitted to humans directly via contact with an animal or indirectly via exposure to the urine or feces of infected animals or the bite of a bloodsucking arthropod. If a virus is able to adapt and replicate in its new human host, human-to-human transmissions may occur, possibly resulting in an epidemic, such as the A/H1N1 flu pandemic in 2009. Thus, predicting emerging zoonotic infections is an important challenge for public health officials in the coming decades. The recent development of viral metagenomics, i.e., the characterization of the complete viral diversity isolated from an organism or an environment using high-throughput sequencing technologies, is promising for the surveillance of such diseases and can be accomplished by analyzing the viromes of selected animals and arthropods that are closely in contact with humans. In this review, we summarize our current knowledge of viral diversity within such animals (in particular blood-feeding arthropods, wildlife and domestic animals) using metagenomics and present its possible future application for the surveillance of zoonotic and arboviral diseases.
GOlorize: a Cytoscape plug-in for network visualization with Gene Ontology-based layout and coloring

UNLABELLED We have implemented a graph layout algorithm that exposes Gene Ontology (GO) class structure on the network nodes. It can be used in conjunction with BiNGO plug-in to Cytoscape, which finds the GO categories over-represented in a given network. Our plug-in, named GOlorize, first highlights the class members with category-specific color-coding and then constructs an enhanced visualization of the network using a class-directed layout algorithm. AVAILABILITY http://www.cytoscape. org/plugins2.php. SUPPLEMENTARY INFORMATION Installation instructions and tutorial at http://www.cytoscape. org/plugins/GOlorize/GOlorizeUserGuide.pdf.
Scale Invariant Feature Transform

Scale Invariant Feature Transform (SIFT) is an image descriptor for image-based matching developed by David Lowe (1999,2004). This descriptor as well as related image descriptors are used for a large number of purposes in computer vision related to point matching between different views of a 3-D scene and view-based object recognition. The SIFT descriptor is invariant to translations, rotations and scaling transformations in the image domain and robust to moderate perspective transformations and illumination variations. Experimentally, the SIFT descriptor has been proven to be very useful in practice for robust image matching and object recognition under real-world conditions.In its original formulation, the SIFT descriptor comprised a method for detecting interest points from a grey-level image at which statistics of local gradient directions of image intensities were accumulated to give a summarizing description of the local image structures in a local neighbourhood around each interest point, with the intention that this descriptor should be used for matching corresponding interest points between different images. Later, the SIFT descriptor has also been applied at dense grids (dense SIFT) which have been shown to lead to better performance for tasks such as object categorization and texture classification. The SIFT descriptor has also been extended from grey-level to colour images and from 2-D spatial images to 2+1-D spatio-temporal video.
Maximizing vector distances using differential evolution—Relation to data redundancy

This paper studies how redundant data affect maximizing of weighted distances of vectors in a set of vectors. To maximize distances differential evolution is used, because the problem does not have analytical solution and is complex. This paper at first describes suppressing of redundant data mathematically and then it checks this theoretical result in two experiments practically. As a result it was found that both experiments are in correspondence with theory.
Influence of mine drainage on regional groundwater of Shilou iron mine in Huaibei City, Anhui Province, China

When mining in mines, it is inevitable to produce water gushing; the influence of large amount of mine drainage on groundwater is a problem that should be taken seriously. Taking Shilou Iron Mine for example, based on regional hydrogeological concept model, the numerical model of groundwater was established, which was identified by water-level simulation and crossflow rate calculation, and then the additional drawdown hydrograph was analyzed by considering whether there was water bursting. The results showed that the maximum drawdown of water level of karst water aquifer in the mining area was 0.2753 and 0.2662 m when considering two months of water inrush and normal water gushing by the end of the third year. In addition, the area where groundwater drawdown was greater than 0.2 m was within the radius of 1,500 m at the center of the pit mine, and the mine drainage was of some influence on regional karst groundwater. Furthermore, the maximum value of pore water aquifer was 0.0126 and 0.0104 m in the same case, and the drawdown funnel was roughly stable, so it had little influence on regional pore groundwater during the study period.
Genetically Encoded Immunophotosensitizer 4D5scFv-miniSOG is a Highly Selective Agent for Targeted Photokilling of Tumor Cells In Vitro

Tumor-targeted delivery of cytotoxins presents considerable advantages over their passive transport. Chemical conjugation of cytotoxic module to antibody is limited due to insufficient reproducibility of synthesis, and recombinant immunotoxins are aimed to overcome this disadvantage. We obtained genetically encoded immunophotosensitizer 4D5scFv-miniSOG and evaluated its photocytotoxic effect in vitro. A single-chain variable fragment (scFv) of humanized 4D5 antibody was used as a targeting vehicle for selective recognition of the extracellular domain of human epidermal growth factor receptor 2 (HER2/neu) overexpressed in many human carcinomas. As a phototoxic module we used a recently described photoactivated fluorescent flavoprotein miniSOG. We found that recombinant protein 4D5scFv-miniSOG exerts a highly specific photo-induced cytotoxic effect on HER2/neu-positive human breast adenocarcinoma SK-BR-3 cells (IC50= 160 nM). We demonstrated that the 4D5scFv-miniSOG specifically binds to HER2-positive cells and internalizes via receptor-mediated endocytosis. Co-treatment of breast cancer cells with 4D5scFv-miniSOG and Taxol or junction opener protein JO-1 produced remarkable additive effects.
On the Range-Data Rate Performance of Outdoor UWB Communication

Major envisioned commercial ultra wideband (UWB) applications are indoor, nonetheless, the suitability of UWB technology for data communication over longer ranges may also have a relevant role in the outdoor wireless communications. In this paper we evaluate and compare the achievable range-data rate performance of a reliable UWB communication link for long ranges, considering an Impulse Radio UWB system and the use of M-ary PAM and M-ary PPM modulations. The free space, lognormal shadowing and two-ray path loss models are considered. We incorporate the UWB frequency dependency of two different ground reflection materials as well as different electric field polarizations in the two-ray path loss model. Tables with the achievable range-data rate performance of the UWB link are provided. Novel results of this research work indicate that, complying with the FCC emission limits, a reliable outdoor UWB link can be established by compromising between range and speed of transmission.
Chemical aspects of compensatory renal hypertrophy.

Summary The effect of unilateral nephrectomy on the size and composition of the remaining kidney has been investigated in rats. In normal rats the right kidney is, on the average, significantly heavier than the left and has a higher total content of DNA and RNA.1 The 2 kidneys have almost identical ratios of RNA/DNA and protein/DNA. After unilateral nephrectomy the surviving kidney increases steadily in wet and dry weight for the 1st 4 days after the operation. This is accompanied by a much slower increase in total DNA content and by a dramatic increase in RNA/DNA ratio. The RNA/DNA ratio in kidney is also affected by diet, being higher on a high-protein than on a low-protein intake. Moreover, the rise in RNA/DNA ratio that follows unilateral nephrectomy is greater in animals fed a high-protein diet. The changes in kidney weight and in total contents of DNA, RNA, protein, and lipid phosphorus resulting from the feeding of a high-protein diet were found to be of approximately the same magnitude as those in the remaining kidney 4 days after unilateral nephrectomy. The RNA/DNA and protein/DNA ratios are also greater in rats fed a diet containing 10% urea, but the increase is much less than that in the remaining kidney after unilateral nephrectomy.
Experimental results on variable structure adaptive robot control without joint velocity measurement

The problem of rigid robot manipulator tracking control without measurement of joint velocities and in the presence of parametric uncertainty is considered. A control strategy is proposed based on the VS-MRAC (variable structure model-reference adaptive control) scheme. Theoretical and experimental results on a PUMA 560 indicate that the strategy leads to remarkable tracking error transient behavior, stability and performance robustness with respect to parameter uncertainty, nonlinearities and disturbances.
MEASUREMENT AND ANALYSIS OF TRAFFIC IN A HYBRID SATELLITE-TERRESTRIAL NETWORK

Measurement and analysis of traffic traces are important for better understanding of network behavior. In this paper, we describe measurements of traffic data from a satellite Internet service provider. We present statistical analysis used to characterize traffic loads and distribution of applications and packet sizes in a hybrid satellite-terrestrial system. We investigate long-range dependence as the traffic patterns vary during a day. We propose a traffic model on the Transmission Control Protocol (TCP) connection level. Finally, we use data from billing records to predict traffic using autoregressive integrated moving average model and evaluate its performance.
Effects of almond consumption on the post-lunch dip and long-term cognitive function in energy-restricted overweight and obese adults

Abstract The post-lunch dip in cognition is a well-established phenomenon of decreased alertness, memory and vigilance after lunch consumption. Lunch composition reportedly influences the post-lunch dip. Moreover, dieting is associated with cognitive function impairments. The negative effects of dieting have been reversed with nut-supplemented diets. The aims of this study were to (1) evaluate the acute effect of an almond-enriched high-fat lunch or high-carbohydrate lunch on the post-lunch decline in cognitive function, and (2) evaluate the effects of chronic almond consumption as part of an energy-restricted diet on the memory and attention domains of cognitive function. In total, eighty-six overweight and obese adults were randomised to consume either an almond-enriched diet (AED) or a nut-free control diet (NFD) over a 12-week weight loss intervention. Participants were also randomised to receive either an almond-enriched high-fat lunch (A-HFL) (>55 % energy from fat, almonds contributing 70–75 % energy) or a high-carbohydrate lunch (HCL) (>85 % energy from carbohydrates) at the beginning and end of the weight loss intervention. Memory and attention performance indices decreased after lunch consumption (P<0·001). The A-HFL group ameliorated the decline in memory scores by 57·7 % compared with the HCL group (P=0·004). Both lunch groups had similar declines in attention. Moreover, memory and attention performance indices increased after the 12-week intervention period (P<0·05) with no difference between the AED and NFD groups. In conclusion, almond consumption at a midday meal can reduce the post-lunch dip in memory. However, long-term almond consumption may not further improve cognitive function outcomes in a weight loss intervention.
Overview of Important Considerations in Wet Gas Compression Testing and Analysis

During upstream production of natural gas fields, it is common that a gas-liquid mixture of product is brought to the surface. The mixture, termed wet gas, is generally made up of mostly gas with a small amount of liquid, typically up to 5% by volume of the mixture. Because of the difficulties of compressing wet gas, the practical approach has been to separate the liquid and gas phases before compression. However, large separation equipment is unfavorable for subsea installations because of the cost to place machinery on the sea floor. Instead, a compressor designed for wet gas operation is preferred because it eliminates the need for large separation equipment leading to plant simplification and cost reduction. To address this design need, researchers have been active in addressing the challenges with wet gas compression. As result, experimental work has been conducted to study the effects of wet gas on compressor aerodynamic and mechanical performance. This experimental research has presented many challenges in recreating wet gas conditions and quantifying the effect of the liquid on the compressor performance. The results from this testing have helped to characterize the performance effects. But so far each work has focused on a range of test variables without identifying those that have the largest effect on compressor performance. This paper aims to provide the reader with an overview of the completed wet gas research, the challenges associated with doing the experimental work, and a discussion of the resulting trends observed in most of the wet gas research. This will include an in-depth review of relevant literature on wet gas compression testing and performance, a discussion of the important
Improved vehicle based multibeam bathymetry using sub-maps and SLAM

This paper presents an algorithm to improve sub-sea acoustic multibeam bottom mapping based on the simultaneous mapping and localization (SLAM) methodology. Multibeam bathymetry from underwater water vehicles can yield valuable large scale terrain maps of the sea door, but the overall accuracy of these maps is typically limited by the accuracy of the vehicle position estimates. The solution presented here uses small bathymetric patches created over short time scales in a sub-mapping context. These patches are registered with respect to one another and assembled in a single coordinate frame to produce a more accurate terrain estimate and provide improved renavigation of the vehicle trajectory. The mapping is implemented using a delayed state extended Kalman filter (EKF) and results are shown for a real world multibeam data set collected at the mid-Atlantic ridge using the JASON ROV.
NPCEditor: A Tool for Building Question-Answering Characters

NPCEditor is a system for building and deploying virtual characters capable of engaging a user in spoken dialog on a limited domain. The dialogue may take any form as long as the character responses can be specified a priori. For example, NPCEditor has been used for constructing question answering characters where a user asks questions and the character responds, but other scenarios are possible. At the core of the system is a state of the art statistical language classification technology for mapping from user's text input to system responses. NPCEditor combines the classifier with a database that stores the character information and relevant language data, a server that allows the character designer to deploy the completed characters, and a user-friendly editor that helps the designer to accomplish both character design and deployment tasks. In the paper we define the overall system architecture, describe individual NPCEditor components, and guide the reader through the steps of building a virtual character.
THE UTILIZATION OF FORMULAE IN OVERHEAD AND PROFIT CLAIMS

Head office overheads are recognized as a justifiable head of claim in claims for loss and expense. However a major difficulty arises in their calculation. For tendering purposes head office overheads are frequently expressed as a factor of company turnover. The majority of claims in which head office overheads appear as a head of claim use a formula for their calculation in which overheads are related in some way to turnover. The main aim of this paper is to investigate the hypothesis that the decisions taken in numerous common law cases would appear to favour the use of a formula method in the recovery of additional general overheads and profit in claims for loss and expense. The text supports the hypothesis.
Effect of concomitant statin, metformin, or aspirin on rituximab treatment for diffuse large B-cell lymphoma

Several pre-clinical studies report that statins interfere with the surface binding of rituximab to CD20. This study investigated the effects of statins in patients with diffuse large B-cell lymphoma (DLBCL) receiving rituximab-based chemoimmunotherapy, and the impact of commonly used drugs, metformin and aspirin, on the clinical outcomes of patients receiving chemoimmunotherapy. We included 213 patients with DLBCL who received rituximab-based chemoimmunotherapy. Details of statin, metformin, and aspirin use and initiation of chemoimmunotherapy were abstracted from medical records. All patients received rituximab, and 47 (22.1%) were taking statins. The median age of patients receiving statins was significantly higher compared to those who did not (p <0.001). Response rates between patients receiving and not receiving statins were not significantly different (85.1% vs. 87.3%; p = 0.688). Event-free survival (EFS) was not significantly different (p = 0.352). Overall survival was lower in patients receiving statins compared to those who did not (p = 0.036). However, it was no longer significant after adjustment for age (p = 0.140). Metformin had no impact on the response rate (p = 0.268), EFS (p = 0.574), and overall survival (p = 0.141). Aspirin had no impact on the response rate (p = 0.784), EFS (p = 0.836), and overall survival (p = 0.779). Statins do not interfere with rituximab, and need not be withheld during rituximab administration. Larger studies are needed to confirm the impact of metformin and aspirin on patients with DLBCL receiving chemoimmunotherapy.