Miracle-dz/UniFAR-FTUs huggingface dataset:
Strategic conceptual design of mid-sized passenger aircraft based on future market performance prediction

In this study, we propose an enhanced strategic concept selection method based on concurrent consideration of future market performance. In the strategic conceptual design of a product, the relationship between the product attributes and market performance (i.e. customer preference in a market) is modeled. The historical relationship shows how the trend in customer preferences has changed over the period and we observed this trend is closely related to economic conditions of a market. The trend of customers’ preferences is again modeled in terms of related economic factors. Finally, the estimated model is used for predicting the market performance of a concept and selecting the best concept. Demonstrating the usefulness of the approach, we employ the conceptual design of mid-sized passenger aircraft in this work. Market performances of 15 concepts of future mid-sized passenger aircraft that will be sold in 2020–2030 are predicted considering global economic conditions of the global oil price, global gross domestic product, and the net profits of airlines. In the high and reference oil price scenarios, the turboprop aircraft with a large number of seats performs best. However, this concept is very sensitive to oil price fluctuations. In contrast, the market performance of a turbofan aircraft with a large number of seats is predicted to be consistently high in all oil price scenarios, as well as robust to the uncertainty in future market conditions.
A hybrid GA-simulation approach to improve JIT systems

This study presents a hybrid approach involving genetic algorithms (GA) as an optimization search technique and a simulation model, for representing the dynamic behavior of the system and its limitations, to improve the practical JIT manufacturing system. To achieve the objective, first, the actual system is modeled and simulated (by considering the system¿s limitations and its dynamic behavior). Second, the integrated simulation model is tested and validated by analysis of variance. Third, the hybrid GA-Simulation approach is used in an interactive manner to determine the optimal number of kanban cards in different stations of the practical JIT system. The presented hybrid approach is tested and applied to an auto industry production line. Furthermore, it is compared with the practical JIT through analysis of variance (ANOVA) and the results show improvements in the average daily production rate, the average resource utilization and the average cycle time but some deterioration in the average queue length and in process inventory is inevitable.
Dementia as a predictor of adverse outcomes following stroke: an evaluation of diagnostic methods.

BACKGROUND AND PURPOSE Although it is understood that dementia is a risk factor for adverse outcomes, little is known about the predictive validity of the numerous methods that have been proposed for its diagnosis. Thus, we performed the present study to assess the utility of a variety of diagnostic methods in the prediction of adverse outcomes following stroke. METHODS We administered neuropsychological, neurological, and functional examinations to 244 patients (age, 71.7+/-8.5 years) 3 months after ischemic stroke. We diagnosed dementia using each of the following methods: (1) neuropsychological testing, requiring deficits in increasing numbers of cognitive domains, both with and without memory impairment, as well as functional impairment; (2) Mini-Mental State Examination (MMSE) score of <24; and (3) neurologists' clinical judgment. We then used survival analyses to investigate the ability of diagnoses based on those methods to predict death and recurrent stroke during long-term follow-up. RESULTS Log-rank tests and Cox proportional hazards analyses, with recurrent stroke entered as a time dependent covariate, determined that all of the paradigms were significant predictors of mortality, but the performance of paradigms based on neuropsychological testing was superior to the use of the MMSE and clinical judgment, particularly when memory impairment was required. Log-rank tests determined that paradigms based on neuropsychological testing were the only significant predictors of recurrent stroke and performed best when memory impairment was required. CONCLUSIONS Our results suggest that dementia diagnosis based on neuropsychological assessment and an operationalized paradigm requiring deficits in memory and other cognitive domains is superior to other conventional methods in its ability to identify patients at elevated risk of adverse outcomes following stroke.
Metacanthomorpha: essay on a phylogeny-oriented database for morphology--the acanthomorph (teleostei) example.

1Equipe “phylogenie,” UMR 7138 “Systematique, adaptation, evolution,” Departement “Systematique et Evolution,” Museum National d’Histoire Naturelle, CP26, 57 rue Cuvier, case postale n◦ 26, 75231 Paris cedex 05, France; E-mail: lecointr@mnhn.fr (G.L.) 2Equipe FishBase, Departement Systematique et Evolution, Museum National d’Histoire Naturelle, CP26, 57 rue Cuvier, 75231 Paris cedex 05, France 3Laboratoire Informatique et Systematique (UMR 5143 Paleobiodiversite et Paleoenvironnements), Universite Pierre et Marie Curie, 12 rue Cuvier, 75005 Paris
Redox-controlled Ligand Exchange of the Heme in the CO-sensing Transcriptional Activator CooA*

The transcriptional activator CooA fromRhodospirillum rubrum contains a b-type heme that acts as a CO sensor in vivo. CooA is the first example of a transcriptional regulator containing a heme as a prosthetic group and of a hemeprotein in which CO plays a physiological role. In this study, we constructed an in vivo reporter system to measure the transcriptional activator activity of CooA and prepared some CooA mutants in which a mutation was introduced at Cys, His, Met, Lys, or Tyr. Only the mutations of Cys75 and His77affected the electronic absorption spectra of the heme in CooA. The electronic absorption spectra, EPR spectra, and the transcriptional activator activity of the wild-type and mutant CooA proteins indicate that 1) the thiolate derived from Cys75 is the axial ligand in the ferric heme, but it is not coordinated to the CO-bound ferrous heme; 2) Cys75 is protonated or displaced in the ferrous heme; and 3) His77 is the proximal ligand in the CO-bound ferrous heme and probably also in the ferrous heme, but it is not coordinated to the ferric heme. NMR spectra reveal that the conformational change around the heme, which will trigger the activation of CooA by CO, takes place upon the binding of CO to the heme.
Growing compact RBF networks using a genetic algorithm

A novel approach for applying genetic algorithms to the configuration of radial basis function networks is presented. A new crossover operator that allows for some control over the competing conventions problem is introduced. Also, a minimalist initialization scheme which tends to generate more parsimonious models is also presented. Finally, a reformulation of generalized cross-validation criterion for model selection, making it more conservative, is discussed. The proposed model is submitted to a computational experiment in order to verify its effectiveness.
ProTK: An Improved Prosody Toolkit

We present an improvement to our previous work to create a toolkit for integrating automated speech recognition, prosodic feature analysis, and machine learning to create models for identifying and classifying speech character-istics such as ﬁlled pauses. The toolkit provides a mod-ular and extensible platform for intaking, analyzing, and formatting data for use in a wide variety of other tools.
Prognostic significance of metabolic enzyme pyruvate kinase M2 in breast cancer

Backgrounds: Numerous studies have reported that aberrant pyruvate kinase M2 isoform (PKM2) expressed in cancer, indicating that PKM2 plays a critical role in tumor initiation and progression. Nevertheless, its prognostic value in breast cancer tumor is yet contentious. Therefore, we performed this meta-analysis to evaluate the prognostic significance of PKM2 in breast cancer. Methods: Eligible relevant literatures were retrieved by searching PubMed, the Cochrane Library, Embase through December 2016. Articles that comparing different PKM2 expression levels in human breast cancer tissues and prognostic significance were included. Software RevMan 5.3 and STATA (Review Manager (RevMan): [Computer program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014. STATA: StataCorp. 2011. Stata Statistical Software: Release 12. College Station, TX: StataCorp LP) were applied to analyze the outcomes. Pooled results were presented in hazardous ratios (HRs) of 5-year overall survival (OS), progression-free survival (PFS), and odds ratios (ORs) of clinicopathological features with 95% confidence intervals. Results: Data from 6 involved studies with 895 patients were summarized. Breast cancer patients with high PKM2 had a worse OS (pooled HR = 1.65, 95% CI = 1.31–2.08, P < .001) and PFS (pooled HR = 2.49, 95% CI = 1.84–3.36, P < .00001). High PKM2 expression is related to lymph node metastasis (N1+N2+N3 vs N0, OR = 1.97, 95%CI = 1.39–2.80, P = .0001). The outcome stability was verified via sensitivity analysis. But elevated PKM2 expression was not correlated to tumor stage (T2+T3 vs T1, pooled OR = 0.80, 95% CI = 0.36–1.77, P = .58) and differential grade (G2+G3 vs G1, OR = 2.74, 95%CI = 0.76–9.84, P = .12). No publication bias was found in the included studies for OS (Begg test, P = .260; Egger test, P = .747). Conclusions: High PKM2 expression denotes worse OS and PFS in breast cancer patients, and correlate with the lymph node metastasis. However, there is no evidence for the impact of PKM2 expression on T stage and tumor differentiation.
Compensation of cross-saturation effects on IPMSM sensorless control - application to electric vehicle

Most of automotive applications rely on Permanent Magnet Synchronous Machines (PMSMs) thanks to the afforded high efficiency and reduced cost and size. However, this trend is subject to severe safety requirements, particulary related to the reliability of the mechanical position sensor. In this context, the present paper deals with PMSM sensorless control, aimed at providing the position information redundancy. Yet, some side effects, as saturation and cross-coupling, may compromise the estimation quality. To achieve a deeper insight into the impact of these phenomena, authors highlight the way that sensorless estimation accuracy is predicted from the rotor geometry anisotropy. The objective is two-fold: (1) Provide a detailed approach for the characterization of the PMSM magnetic model under different load conditions, (2) Deduce the machine saliency behaviour and the induced estimation error due to saturation effects. To do so, an accurate flux linkage model is required. This model should allow to evaluate the arising cross-saturation terms. Experimental results are presented, referring to two test traction motors dedicated to the electric vehicle application.
Breakdown of Mucosal Immunity in the Gut and Resultant Systemic Sensitization by Oral Antigens in a Murine Model for Systemic Lupus Erythematosus 1

Secreted IgA plays a pivotal role in the mucosal immunity to maintain the front line of body defense. We found that the level of fecal IgA was dramatically decreased in aged (NZB × NZW)F1 (BWF1) mice developing lupus nephritis, whereas levels in similarly aged New Zealand Black (NZB) and New Zealand White (NZW) mice remained unchanged compared with young mice. The number of cells obtained from Peyer’s patches was markedly decreased in aged BWF1 mice. Aged BWF1 mice showed increased susceptibility to pathogenic bacterial infection. Furthermore, oral administration of OVA failed to inhibit secondary IgG response induced by systemic immunization, suggesting defective oral tolerance in aged BWF1 mice. A significant amount of orally administered OVA was incorporated directly into the intestinal lamina propria in aged BWF1 mice whereas it was mainly localized in subepithelial domes and interfollicular region in Peyer’s patches in young mice. T cells obtained from renal and pulmonary lymph nodes of aged BWF1 mice that had been orally administered with OVA showed an Ag-specific T cell proliferation, whereas those from young BWF1, aged NZB, and aged NZW mice did not. Interestingly, aerosol exposure to OVA of aged BWF1 mice, which had been orally administered with the same Ag, provoked an eosinophil infiltration in the lung. These results demonstrate that mucosal immunity in the gut is impaired and oral Ags induce systemic sensitization instead of oral tolerance in the development of murine lupus.
The Dynamic Multisensory Engram: Neural Circuitry Underlying Crossmodal Object Recognition in Rats Changes with the Nature of Object Experience

Rats, humans, and monkeys demonstrate robust crossmodal object recognition (CMOR), identifying objects across sensory modalities. We have shown that rats' performance of a spontaneous tactile-to-visual CMOR task requires functional integration of perirhinal (PRh) and posterior parietal (PPC) cortices, which seemingly provide visual and tactile object feature processing, respectively. However, research with primates has suggested that PRh is sufficient for multisensory object representation. We tested this hypothesis in rats using a modification of the CMOR task in which multimodal preexposure to the to-be-remembered objects significantly facilitates performance. In the original CMOR task, with no preexposure, reversible lesions of PRh or PPC produced patterns of impairment consistent with modality-specific contributions. Conversely, in the CMOR task with preexposure, PPC lesions had no effect, whereas PRh involvement was robust, proving necessary for phases of the task that did not require PRh activity when rats did not have preexposure; this pattern was supported by results from c-fos imaging. We suggest that multimodal preexposure alters the circuitry responsible for object recognition, in this case obviating the need for PPC contributions and expanding PRh involvement, consistent with the polymodal nature of PRh connections and results from primates indicating a key role for PRh in multisensory object representation. These findings have significant implications for our understanding of multisensory information processing, suggesting that the nature of an individual's past experience with an object strongly determines the brain circuitry involved in representing that object's multisensory features in memory. SIGNIFICANCE STATEMENT The ability to integrate information from multiple sensory modalities is crucial to the survival of organisms living in complex environments. Appropriate responses to behaviorally relevant objects are informed by integration of multisensory object features. We used crossmodal object recognition tasks in rats to study the neurobiological basis of multisensory object representation. When rats had no prior exposure to the to-be-remembered objects, the spontaneous ability to recognize objects across sensory modalities relied on functional interaction between multiple cortical regions. However, prior multisensory exploration of the task-relevant objects remapped cortical contributions, negating the involvement of one region and significantly expanding the role of another. This finding emphasizes the dynamic nature of cortical representation of objects in relation to past experience.
Improving Engineering Data Management with Semantic Web Techniques

Throughout the IT communities, it has been acknowledged that ontology plays a key role in representation and reuse of knowledge. This paper discusses some issues of ontology construction for engineering data management, such as knowledge discovery, knowledge representation and semantic services. All discussions are followed by a running ex-ample of engineering data management. Based on the user needs with five phases of engineering design, the issue of knowledge discovery will be presented. The built knowledge base contains basic knowledge models and vocabularies for knowledge integration. With the semantics of semistructured data, the hierarchical relations of concepts in engi-neering data have been extracted for reuse in future engineering design based on some clustering techniques of data mining. Semantic services for engineering design will be provided with the ontology-based schema.
The transcriptional programme of contact‐inhibition

Proliferation of non‐transformed cells is regulated by cell–cell contacts, which are referred to as contact‐inhibition. Vice versa, transformed cells are characterised by a loss of contact‐inhibition. Despite its generally accepted importance for cell‐cycle control, little is known about the intracellular signalling pathways involved in contact‐inhibition. Unravelling the molecular mechanisms of contact‐inhibition and its loss during tumourigenesis will be an important step towards the identification of novel target genes in tumour diagnosis and treatment. To better understand the underlying molecular mechanisms we identified the transcriptional programme of contact‐inhibition in NIH3T3 fibroblast using high‐density microarrays. Setting the cut off: ≥1.5‐fold, P ≤ 0.05, 853 genes and 73 cDNA sequences were differentially expressed in confluent compared to exponentially growing cultures. Importing these data into GenMAPP software revealed a comprehensive list of cell‐cycle regulatory genes mediating G0/G1 arrest, which was confirmed by RT‐PCR and Western blot. In a narrow analysis (cut off: ≥2‐fold, P ≤ 0.002), we found 110 transcripts to be differentially expressed representing 107 genes and 3 cDNA sequences involved, for example, in proliferation, signal transduction, transcriptional regulation, cell adhesion and communication. Interestingly, the majority of genes was upregulated indicating that contact‐inhibition is not a passive state, but actively induced. Furthermore, we confirmed differential expression of eight genes by semi‐quantitative RT‐PCR and identified the potential tumour suppressor transforming growth factor‐β (TGF‐β)‐1‐induced clone 22 (TSC‐22; tgfb1i4) as a novel protein to be induced in contact‐inhibited cells. J. Cell. Biochem. 110: 1234–1243, 2010. Published 2010 Wiley‐Liss, Inc.
Sinusoid-locked loops based on the principles of synchronous machines

Phase-locked loops (PLL), which are widely applied to track the phase of a periodic signal, play an important role in modern electrical engineering. For some applications, it is also necessary to track the amplitude and the frequency of a signal (often sinusoidal), in addition to its phase. A strategy/device that is able to track the amplitude, frequency and phase of the fundamental component of a signal is called a sinusoid-locked loop (SLL). For a synchronous machine connected to the utility grid, the (real and reactive) power exchanged with the grid can be controlled to be zero. In this case, the phase, the frequency and the amplitude of the voltage generated by the machine are the same as those of the grid voltage and the machine is floating on the grid, as an SLL. In this paper, following the recently-proposed synchronverter concept, a virtual synchronous machine is controlled to implement this function so that it is operated as an SLL to provide the phase, frequency and amplitude of the fundamental component of the voltage supplied. Simulation results are provided to demonstrate its excellent performance, with comparison made to some other major approaches.
ANGIOGRAPHY OF THE CORONARY CIRCULATION IN LIVING DOGS USING TIMED DIASTOLIC INJECTIONS

Reliable demonstration of the coronary arteries in the living is possible if special techniques are used. A historical summary and review of various methods will be found in publications by Dotter and Frische (1958) and Michell (1960). In a previous communication from this department (Sloman and Jefferson, 1960) a technique of coronary arteriography in living dogs was described using acetyl-choline cardiac arrest. It was thought, however, that this procedure was potentially dangerous and a safer method was sought. The present investigation was undertaken to try the effect of timing injections of radio-opaque medium to occur in diastole, a method suggested by Richards and Thal (1958). Maximal coronary flow occurs during ventricular diastole, while flow may be actually reversed in systole (Green et al., 1935; Gregg, 1950). Therefore, medium injected into the root of the aorta during diastole should result in good coronary artery filling, whereas systolic injection should produce poor opacification.
The confluence of mental, physical, social, and academic difficulties in middle childhood. II: developing the Macarthur health and Behavior Questionnaire.

OBJECTIVES (1) To evaluate the psychometric properties of the MacArthur Health and Behavior Questionnaire (HBQ) in two studies of 4- to 8-year-old children and (2) to explore the empirical and theoretical implications of HBQ-based study findings. METHOD Samples of children were recruited from (1) mental health clinics (n = 53) and community schools (n = 67) for a case-control study in three research sites and (2) a Wisconsin-based community cohort study of families and work, comprising children with high levels of internalizing and/or externalizing behavior problems and asymptomatic children (N = 122). Combinations of mothers, fathers, and teachers completed the HBQ at one or two time points in four geographically and culturally distinctive settings. RESULTS Assessment of HBQ reliability showed high test-retest stability and cross-informant agreement. The instrument discriminated strongly and significantly among symptom groups (i.e., high internalizing, high externalizing, high both, and low both) and showed moderate to large effect sizes for between-group differences. Substantial covariance was also found among the HBQ mental, physical, social, and academic problem subscales. CONCLUSIONS The HBQ is a reliable and valid parent- and teacher-report instrument for assessing multiple dimensions of health and dysfunction in middle childhood and for identifying children on whom more intensive diagnostic procedures may be warranted. Confluences among the four health dimensions suggest phenomenological and perhaps etiological commonalities among traditionally partitioned childhood difficulties and suggest possible artificiality in the conventional distinction between pediatric and child psychiatric morbidities.