Miracle-dz/UniFAR-FTUs huggingface dataset:
Beyond Culture and (National) Identity? Language, Globalization and the Discourse of Universal Progress in American Newspaper Coverage of English

Abstract This paper critically interrogates discursive appeals to linguistic and communicative universality. It does so primarily by way of the analysis of discourses on the global hegemony of English in five American-owned prestige press publications—the Los Angeles Times, the International Herald Tribune, The New York Times, The Wall Street Journal, and The Washington Post. It also draws parallels between broader contemporary and historical examples of what the author defines as a discourse of universal progress on English. This discourse frames the hegemony of English as a simple and largely unproblematic fact of the global order while celebrating its allegedly intrinsic progressive tendencies and capabilities. Among these are English's superiority as a purveyor of “objective” reality, its ability to facilitate individual and collective (economic) success, its capacity to advance the production and exchange of knowledge and information, and its status as a bestower of universal (global) voice and unity. The author challenges some of the assumptions that underlie this discourse, contending that, at the highest levels of abstraction, the discourse of universal progress strips English and language of their rootedness in culture and various forms of social identity and struggle.
What students think when teachers get upset: Fundamental attribution error and student‐generated reasons for teacher anger

Using a sample of college students (N = 301), this study examined students' attributions about and explanations for teachers' expressions of anger in the classroom. These displays of anger were evaluated based on the extent to which they were aggressive (e.g., Distributive or Passive) or assertive (e.g., Integrative). Consistent with the fundamental attribution error, students assigned internal attributions to teachers who used Distributive Aggression (e.g., yell and scream) and Passive‐Aggression (e.g., show anger with cold looks) to a greater extent than teachers who were Assertive (i.e., calmly discuss the problem with the students). When students were asked to identify why they thought their teacher was angry, the overwhelming majority of reasons involved student‐related problems. In fact, the most frequently cited reason was Student Misbehaviors followed by Lack of Student Effort. Surprisingly, students acknowledge that something they did triggered the teacher's display of anger; however, consistent with fundamental attribution error, students still attributed the teacher's expression of anger to internal causes. The implications of these findings for negative emotional expressions in the instructional context in particular and for teacher‐student relationships in general are discussed.
Post-operative arterial thrombosis with non-vitamin K antagonist oral anticoagulants after total hip or knee arthroplasty

Summary The incidence of post-operative arterial thrombosis (AT) (acute myocardial infarction [AMI] and ischaemic stroke) is increased in patients undergoing total hip replacement (THR) or total knee replacement (TKR). We compared the incidence of post-operative AT in non-vitamin K antagonist oral anticoagulants (NOACs)-treated and enoxaparintreated patients, performing a systematic review of phase III randomised controlled trials (RCTs) of venous thromboembolism (VTE) prophylaxis in THR and TKR. Studies were identified by electronic search of MEDLINE and EMBASE database until July 2014. Differences between NOACs and enoxaparin groups in the efficacy and safety outcomes were expressed as odds ratios (ORs) with pertinent 95 % confidence intervals (95 % CI). Statistical heterogeneity was assessed with the I2 statistic. Eleven phase III RCTs for a total of 31,319 patients were included. Patients underwent TKR in six studies and THR in five studies. The NOACs under study were dabigatran (four studies), apixaban (three studies) and rivaroxaban (four studies). AT occurred in 0.23 % of patients on NOACs and in 0.27 % of patients on enoxaparin: the OR at fixed-effect model was 0.86 (95 % CI 0.53–1.40; I2 11 %). No differences in AT incidence among the three NOACs were observed. The incidence of major and clinically relevant bleeding was similar in NOACs and enoxaparin groups (OR 1.03, 95 % CI 0.92–1.15; I2 38 %). In conclusion, in RCTs of pharmacological VTE prophylaxis in patients undergoing THR or TKR, there was no difference in the incidence of post-operative AT among patients treated with NOACs, compared to those treated with enoxaparin. Note: An abstract of this paper has been accepted as oral presentation at the XXIII Congress of SISET, Italian Society of Thrombosis and Haemostasis, 6–9 November 2014, Milan (Italy).
Fallen stock data: An essential source of information for quantitative knowledge of equine mortality in France

Summary Background Quantitative information about equine mortality is relatively scarce, yet it could be of great value for epidemiological purposes. In France, data from rendering plants are centralised in the Fallen Stock Data Interchange database (FSDI), managed by the French Ministry of Agriculture, while individual equine data are centralised in the French equine census database, SIRE, managed by the French horse and riding institute (IFCE). Objectives To evaluate whether the combined use of the FSDI and SIRE databases can provide representative and accurate quantitative information on mortality for the French equine population and to propose enhancements of these databases to improve the quality of the resulting demographic information. Study design Descriptive study. Methods Mortality ratios for the French equine population were calculated per year between 2011 and 2014 and temporal variations in equine mortality modelled during the same period. Survival analyses were performed on a sample of equines traceable in both the FSDI and SIRE databases. Results Estimates of the annual mortality ratios varied from 3.02 to 3.40% depending on the years. Survival rates of equines 2‐years‐old and over differed according to breed categories with the highest median age at death for the ponies. The weekly description of mortality highlighted marked seasonality of deaths whatever the category of equines. Modelling temporal variations in equine mortality also brought to light excess mortality. Main limitations Insufficient traceability of equines between the two databases. Conclusion The FSDI database provided an initial approach to equine death ratios on a national scale and an original description of temporal variations in mortality. Improvement in the traceability of equines between the FSDI and SIRE databases is needed to enable their combined use, providing a representative description of equine longevity and a more detailed description of temporal variations in mortality.
Representations of the Intellectual

This article explores the contemporary relationship between management educators and practitioners, as expressed in the Critical Management Studies (CMS) literature, in the light of Gramsci’s writings on the formation and roles of intellectuals within society. His conception of intellectuals as being of two types—organic and traditional—is used as a heuristic to explore the claims made by critical management studies for an emancipatory agenda. Using Gramsci’s writings as a point of departure I stake out a position that starts to reconsider how management educators have come to acquire their perceived position of governance over what passes as management knowledge. I suggest that to do this we need to consider management education’s socio-cultural position. I adopt Gramsci’s notion of the ‘system of relations’ as a way to focus on the relationships between management education, management educators, and management practitioners. The article suggests that CMS needs to pay attention to the pedagogical processes of management education as much as to its content. I conclude that research that observes what are currently perceived as ‘critical’ and ‘non-critical’ management education classrooms must take place. Until this occurs, CMS’s claims for an emancipatory agenda must remain muted.
African American women describe support processes during high-risk pregnancy and postpartum.

OBJECTIVE To explore social support processes in low-income African American women during high-risk pregnancy and postpartum. DESIGN A qualitative grounded theory approach. Interview was the primary data collection technique and was combined with observation, medical chart review, and literature review. SETTING A high-risk pregnancy clinic and participants' homes. PARTICIPANTS Ten pregnant women, 3 social network members, and 11 health care providers. Four of the women at high risk tell their in-depth stories in this article: Yolanda, coping with gestational diabetes; Frances, participating in drug rehabilitation; Trista, waiting to deliver a fetus with severe congenital anomalies; and Beatrice, HIV positive and carrying her seventh child. RESULTS The substantive theory of support developed in the study was termed mutual intentionality. Narratives illustrate the mutual roles that women at high risk and support givers played in the helping process. Support themes included being there, caring, respecting, sharing information, knowing, believing in, and doing for the other. CONCLUSION The theorsy of mutual intentionality suggests that social support is a process or transaction involving intentionality. For support to happen, the therapeutic relationship must be valued as a mutual resource.
A sensitivity analysis of RNA folding nearest neighbor parameters identifies a subset of free energy parameters with the greatest impact on RNA secondary structure prediction

Abstract Nearest neighbor parameters for estimating the folding energy changes of RNA secondary structures are used in structure prediction and analysis. Despite their widespread application, a comprehensive analysis of the impact of each parameter on the precision of calculations had not been conducted. To identify the parameters with greatest impact, a sensitivity analysis was performed on the 291 parameters that compose the 2004 version of the free energy nearest neighbor rules. Perturbed parameter sets were generated by perturbing each parameter independently. Then the effect of each individual parameter change on predicted base-pair probabilities and secondary structures as compared to the standard parameter set was observed for a set of sequences including structured ncRNA, mRNA and randomized sequences. The results identify for the first time the parameters with the greatest impact on secondary structure prediction, and the subset which should be prioritized for further study in order to improve the precision of structure prediction. In particular, bulge loop initiation, multibranch loop initiation, AU/GU internal loop closure and AU/GU helix end parameters were particularly important. An analysis of parameter usage during folding free energy calculations of stochastic samples of secondary structures revealed a correlation between parameter usage and impact on structure prediction precision.
The tell-tale accent: Identification of regionally marked speech in German telephone conversations by forensic phoneticians

One of the most significant features in forensic phonetics used to identify a speaker is his or her so-called regional accent. In a speaker profiling task, German experts for voice comparison were evaluated concerning their performance and their methodological approach in accent identification. As a result, the experts as a group performed well; only very few severe confusions of regional accents occurred. Results also showed that the experts applied different strategies in identifying a speaker´s regional accent; the different methods were (a) aural-perceptual analysis, (b) acoustic analysis, (c) consultation of audio databases, and (d) consultation of literature on dialects. Participants also differed considerably in the amount of time they needed to complete the task. The most important finding is that no correlations existed between the performance (i.e. error rate) of the participants and (a) the time spent, (b) the number of methods applied, (c) the kind of method applied or (d) the perceived degree of difficulty. This leads to the conclusion that the performance in dialect identification may predominantly depend on the individual (innate or trained) skills of the expert in speaker identification.
Vision-related fitness to drive mobility scooters: A practical driving test.

OBJECTIVE To investigate practical fitness to drive mobility scooters, comparing visually impaired participants with healthy controls. DESIGN Between-subjects design. SUBJECTS Forty-six visually impaired (13 with very low visual acuity, 10 with low visual acuity, 11 with peripheral field defects, 12 with multiple visual impairment) and 35 normal-sighted controls. METHODS Participants completed a practical mobility scooter test-drive, which was recorded on video. Two independent occupational therapists specialized in orientation and mobility evaluated the videos systematically. RESULTS Approximately 90% of the visually impaired participants passed the driving test. On average, participants with visual impairments performed worse than normal-sighted controls, but were judged sufficiently safe. In particular, difficulties were observed in participants with peripheral visual field defects and those with a combination of low visual acuity and visual field defects. CONCLUSION People with visual impairment are, in practice, fit to drive mobility scooters; thus visual impairment on its own should not be viewed as a determinant of safety to drive mobility scooters. However, special attention should be paid to individuals with visual field defects with or without a combined low visual acuity. The use of an individual practical fitness-to-drive test is advised.
In search of arenas for democratic deliberation: a Habermasian review of environmental assessment

In this paper the deliberative potential of environmental assessment (EA) is explored. The analysis is structured around four principles derived from Jürgen Habermas's conception of discourse as an ideal procedure for rational and democratic decision-making. The results show that there are many barriers to an implementation of the Habermasian principles. Nevertheless, it is concluded that EA has a ‘hidden’ deliberative potential, which follows from the institutional flexibility of EA, that is, because EA legislation specifies minimal requirement for public participation, requirements that developers and authorities can exceed by using more inclusive and more dialogue-based participatory tools. Finally, the need for additional investigations of deliberation in EA is discussed.
Discrete-continuous optimization for multi-target tracking

The problem of multi-target tracking is comprised of two distinct, but tightly coupled challenges: (i) the naturally discrete problem of data association, i.e. assigning image observations to the appropriate target; (ii) the naturally continuous problem of trajectory estimation, i.e. recovering the trajectories of all targets. To go beyond simple greedy solutions for data association, recent approaches often perform multi-target tracking using discrete optimization. This has the disadvantage that trajectories need to be pre-computed or represented discretely, thus limiting accuracy. In this paper we instead formulate multi-target tracking as a discrete-continuous optimization problem that handles each aspect in its natural domain and allows leveraging powerful methods for multi-model fitting. Data association is performed using discrete optimization with label costs, yielding near optimality. Trajectory estimation is posed as a continuous fitting problem with a simple closed-form solution, which is used in turn to update the label costs. We demonstrate the accuracy and robustness of our approach with state-of-the-art performance on several standard datasets.
Structure-Function Relationships behind the Phenomenon of Cognitive Resilience in Neurology: Insights for Neuroscience and Medicine

The phenomenon of cognitive resilience, that is, the dynamical preservation of normal functions despite neurological disorders, demonstrates that cognition can be highly robust to devastating brain injury. Here, cognitive resilience is considered across a range of neurological conditions. Simple computational models of structure-function relationships are used to discuss hypotheses about the neural mechanisms of resilience. Resilience expresses functional redundancies in brain networks and suggests a process of dynamic rerouting of brain signals. This process is underlined by a global renormalization of effective connectivity, capable of restoring information transfer between spared brain structures via alternate pathways. Local mechanisms of synaptic plasticity mediate the renormalization at the lowest level of implementation, but it is also driven by top-down cognition, with a key role of self-awareness in fostering resilience. The presence of abstraction layers in brain computation and networking is hypothesized to account for the renormalization process. Future research directions and challenges are discussed regarding the understanding and control of resilience based on multimodal neuroimaging and computational neuroscience. The study of resilience will illuminate ways by which the brain can overcome adversity and help inform prevention and treatment strategies. It is relevant to combating the negative neuropsychological impact of aging and fostering cognitive enhancement.
Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis

Translesion synthesis (TLS) is the major pathway by which mammalian cells replicate across DNA lesions. Upon DNA damage, ubiquitination of proliferating cell nuclear antigen (PCNA) induces bypass of the lesion by directing the replication machinery into the TLS pathway. Yet, how this modification is recognized and interpreted in the cell remains unclear. Here we describe the identification of two ubiquitin (Ub)–binding domains (UBM and UBZ), which are evolutionarily conserved in all Y-family TLS polymerases (pols). These domains are required for binding of polη and polι to ubiquitin, their accumulation in replication factories, and their interaction with monoubiquitinated PCNA. Moreover, the UBZ domain of polη is essential to efficiently restore a normal response to ultraviolet irradiation in xeroderma pigmentosum variant (XP-V) fibroblasts. Our results indicate that Ub-binding domains of Y-family polymerases play crucial regulatory roles in TLS.
MicroRNA-503 suppresses cell proliferation and invasion in osteosarcoma via targeting insulin-like growth factor 1 receptor

MicroRNAs (miRs) are a class of small non-coding RNAs and have key roles in various cancer types. Recently, miR-503 has been reported to act as a tumor suppressor in osteosarcoma. However, the detailed mechanism of the regulatory role of miR-503 in osteosarcoma cell proliferation and invasion has largely remained elusive. The present study found that miR-503 was significantly downregulated in osteosarcoma tissues compared to that in matched adjacent non-tumorous tissues. In addition, the expression of miR-503 in osteosarcoma of T3-T4 stage was significantly lower when compared with that in T1-T2 stage samples. miR-503 was also downregulated in osteosarcoma cell lines (Saos-2, MG63, U2OS and SW1353), when compared with that in the normal osteoblast cell line hFOB. Overexpression of miR-503 significantly inhibited the proliferation and invasion of U2OS cells and decreased the protein levels of insulin-like growth factor 1 receptor (IGF-1R), which was further identified as a novel target of miR-503 by a luciferase reporter assay. Moreover, overexpression of IGF-1R eliminated the suppressive effects of miR-503 on the proliferation and invasion of U2OS cells, suggesting that miR-503 inhibits osteosarcoma cell proliferation and invasion by directly targeting IGF-1R. Furthermore, IGF-1R was significantly upregulated in osteosarcoma tissues compared with that in adjacent non-tumor tissues, as well as in osteosarcoma cell lines compared with that in hFOB cells. In addition, the expression levels of IGF-1R were inversely correlated to the miR-503 levels in osteosarcoma tissues, suggesting that the increased IGF-1R expression may be caused by the reduced expression of miR-503. In conclusion, the present study demonstrated that miR-503 suppresses cell proliferation and invasion in osteosarcoma via targeting IGF-1R and thus highlights the importance of miR-503/IGF-1R signaling in the malignant progression of osteosarcoma.
Structure and mechanism of the Hsp90 molecular chaperone machinery.

Heat shock protein 90 (Hsp90) is a molecular chaperone essential for activating many signaling proteins in the eukaryotic cell. Biochemical and structural analysis of Hsp90 has revealed a complex mechanism of ATPase-coupled conformational changes and interactions with cochaperone proteins, which facilitate activation of Hsp90's diverse "clientele. " Despite recent progress, key aspects of the ATPase-coupled mechanism of Hsp90 remain controversial, and the nature of the changes, engendered by Hsp90 in client proteins, is largely unknown. Here, we discuss present knowledge of Hsp90 structure and function gleaned from crystallographic studies of individual domains and recent progress in obtaining a structure for the ATP-bound conformation of the intact dimeric chaperone. Additionally, we describe the roles of the plethora of cochaperones with which Hsp90 cooperates and growing insights into their biochemical mechanisms, which come from crystal structures of Hsp90 cochaperone complexes.
Evaluation of the ecological characteristics in the vector of anthroponotic cutaneous leishmaniasis in a new focus of Mohammad Abad, Kerman, southeast of Iran

Abbas Aghaei Afshar, Maryam Hakimi Parizi, Iraj Sharifi, Mohammad Amin Gorouhi, Fatemeh Sharifi, Bismark Baafi Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran Department of Environmental Health and Medical Entomology, School of Health, Kerman University of Medical Sciences, Kerman, Iran Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran School of Public Health, International Campus, Tehran University of Medical Sciences, Tehran, Iran Asian Pac J Trop Dis 2017; 7(2): 84-87
Echo, not quotation: what conversation analysis reveals about classroom responses to heard poetry

This article applies conversation analysis to classroom talk-in-interaction where pupils respond to poetry they have heard. The phenomenon of repeating in discussion details from the poem, including patterns of delivery, is considered and named echo to distinguish it from quotation in writing. The phenomenon is significant to the pedagogy of literary study given the existing tacit and unexamined assumption that when pupils repeat textual details verbally this has equivalence with quotation in writing. Three episodes drawn from a single sequence of classroom interaction are presented together with a transcript of the stimulus heard poem. Each is accompanied by an interpretive commentary. It appears that echo in classroom discussions of poetry performs actions distinct from quotation in writing, for example that the acts of presenting and analysing textual detail occur simultaneously. The innovation of the research lies in the inclusion of the transcript-rendered poem as a turn in the sequence of interaction: as a verbally oriented method, conversation analysis provides an apt means of rendering response to poetry presented in the oral mode. More broadly, the discussion is consistent with the emergent popularity of conversation analysis as a method for considering classroom interactions with a view to reflecting on subtle aspects of learning.