Miracle-dz/UniFAR-FTUs huggingface dataset:
An optimum interference mitigating combining scheme for the CDMA downlink with the same complexity as MRC

This letter presents a new optimum interference mitigating combining (OIMC) scheme for the code-division multiple-access downlink RAKE receiver. The OIMC scheme optimizes the RAKE weights and maximizes the signal-to-interference-plus-noise ratio (SINR) at the RAKE combiner output. Unlike other interference mitigation schemes, the new scheme does not need to estimate the interference or data correlation matrix (and its inverse) of the received signal to render a reliable and low complexity receiver. The OIMC scheme mitigates interference by inversely proportionately weighting the finger output by its associated interference power, while simultaneously mitigating multipath fading. The interference power is found to be directly related to the finger's associated multipath channel gain, rendering the OIMC scheme with the same order of complexity as a maximal ratio combining (MRC) scheme. Under realistic channel conditions, simulation results show that the proposed OIMC scheme always outperforms MRC with a gain of up to more than 1 dB.
Direct Measurement of Loads at the Temporomandibular Joint in Macaca arctoides

Loads at the articulating surface of the head of the condyle were recorded in one male adult Macaca arctoides. Following surgical implantation of the pressure-sensitive foil, the monkey was given hard and soft foods to chew. Loads were recorded during incisal biting and molar chewing. The bite data showed the following: The condylar head was loaded during molar chewing with a maximum load of 1-3 lb. The condylar head was loaded with a larger load of 3-4 lb during incisal biting.
Evidence-Based Practice in the Treatment of OCD

Kazdin (2007) and Barlow (2007) elucidated the components of evidence-based practice and affirmed the Story of Hope (Clement, 2007) as an illustration of how such practice can be accomplished within a full-time private practice. These three psychologists agreed on a number of points. Evidence-based practice includes (a) systematic evaluation of individual patients with repeated administration of brief, objective measures before, during, and following treatment, (b) accurate diagnosis in order to select the most appropriate treatment(s) for the patient in question, (c) whenever possible using an empirically supported treatment (EST), (d) relating research findings to clinical practice and outcomes from psychotherapy back to research, (e) adapting treatment components to the particular patient and their specific circumstances, (f) continually analyzing progress, and (g) accumulating treatment outcomes across cases into a database. Finally, regarding the case of Hope herself, although there had been a drop in her level of functioning at a 21-month, post-treatment follow-up, HopeAƒÂ¢A‚â‚¬A‚â„¢s treatment effect size was still very large (2.57).
Interference and electromagnetic compatibility challenges in 5G wireless network deployments

5G wireless network technology is going operate within the environment of other electrical, electronic and electromagnetic devices, components and systems, with capability of high speed data connectivity acting as network transceiver stations with Massive MIMO for Internet of Things (IoT). Considering the level of interoperability, electromagnetic Interference and electromagnetic compatibility to avoid electromagnetic pulse effects (EMP) which is capable of not only causing network malfunctions but total devices and equipments failure in mission critical operations, like hospital MRI scan machines, security profiling and data handling or even personal healthcare devices like heart pacemaker. Electromagnetic energy coupling in PCB due to: radiation, reflection and Crosstalk generates reliability challenges affecting Signal Integrity between traces of multilayer boards stalks, power bus and packaging creating Electromagnetic interference (EMI) in PCB leading false clock response to system failure. Above were considered very essential when deploying 5G wireless network facility as presented in this paper.
Density Estimation Technique for Data Stream Classification

Density estimation is an important pre-processing step in the problem of data stream classification in which the number of data is overwhelming and the exact data distribution is unknown. We simplify the problem by employing a statistical sampling technique to obtain an approximate solution. With the proposed method, an unbounded large data set can be sampled in a number of random configurations, and that data can be used to describe the data set as a whole. The efficiency of the method depends largely on the ability to draw samples effectively which in turn depends on how close we can estimate the target density. We use finite mixture models to represent the probability density functions of the data stream. Then, we apply the EM algorithm twice to learn the model parameters. The efficiency of our estimation technique has been shown in the experimental results
Regulation of Second Messenger Signaling in Hypoxic Neonatal Rats : Effect of Glucose , Oxygen and Epinephrine Resuscitation

Cell signaling via second messengers plays an important role in control of respiration under hypoxia. Second messenger alterations and its further complications in respiration due to neonatal hypoxic insult and the effect of glucose, oxygen and epinephrine resuscitation were evaluated in the present study. Second messenger assays and gene expression studies on CREB and phospholipase C were done in corpus striatum to analyze changes in second messenger signaling cascade. Neonatal hypoxia increased the concentration of IP3, cAMP and cGMP in the corpus striatum. The gene expression of downstream transcription factors in cell signaling CREB was down regulated and phospholipase C was up regulated in neonatal hypoxic rats. These disturbances were reversed to near control in glucose resuscitated hypoxic neonates. The adverse effects of immediate oxygenation and epinephrine administration are also reported. This has immense clinical significance in establishing a proper resuscitation for management of neonatal hypoxia. Keywords— cAMP, cGMP, CREB, IP3, phospholipase C.
Mutational Definition of Functional Domains within the Rev Homolog Encoded by Human Endogenous Retrovirus K

ABSTRACT Nuclear export of the incompletely spliced mRNAs encoded by several complex retroviruses, including human immunodeficiency virus type 1 (HIV-1), is dependent on a virally encoded adapter protein, termed Rev in HIV-1, that directly binds both to a cis-acting viral RNA target site and to the cellular Crm1 export factor. Human endogenous retrovirus K, a family of ancient endogenous retroviruses that is not related to the exogenous retrovirus HIV-1, was recently shown to also encode a Crm1-dependent nuclear RNA export factor, termed K-Rev. Although HIV-1 Rev and K-Rev display little sequence identity, they share the ability not only to bind to Crm1 and to RNA but also to form homomultimers and shuttle between nucleus and cytoplasm. We have used mutational analysis to identify sequences in the 105-amino-acid K-Rev protein required for each of these distinct biological activities. While mutations in K-Rev that inactivate any one of these properties also blocked K-Rev-dependent nuclear RNA export, several K-Rev mutants were comparable to wild type when assayed for any of these individual activities yet nevertheless defective for RNA export. Although several nonfunctional K-Rev mutants acted as dominant negative inhibitors of K-Rev-, but not HIV-1 Rev-, dependent RNA export, these were not defined by their inability to bind to Crm1, as is seen with HIV-1 Rev. In total, this analysis suggests a functional architecture for K-Rev that is similar to, but distinct from, that described for HIV-1 Rev and raises the possibility that viral RNA export mediated by the ∼25 million-year-old K-Rev protein may require an additional cellular cofactor that is not required for HIV-1 Rev function.
Motivated False Memory

People often forget and sometimes fantasize. This paper reports a large-scale experiment on memory errors and their relation to preferential traits including time preference, attitudes toward risk and ambiguity, and psychological characteristics such as anticipatory feelings. We observe systematic incidences of false memory in favor of positive events and positive amnesia in forgetting past negative events. Both positive delusion and positive confabulation significantly relate to present bias, but this is not the case for positive amnesia. In an intraperson, multiple-self model, we demonstrate that positive false memory, rather than selective amnesia, serves to enhance confidence in one’s future self in equilibrium, thereby accounting for our experimental findings.
The cumulative effect of genetic polymorphisms on depression and brain structural integrity

In major depressive disorder (MDD), the need to study multiple‐gene effect on brain structure is emerging. Our aim was to assess the effect of accumulation of specific SERT, BDNF and COMT gene functional polymorphisms on brain structure in MDD patients. Seventy‐seven MDD patients and 66 controls underwent a clinical assessment, genetic testing and MRI scan. Compared with controls, patients were more BDNF‐Val homozygotes, COMT‐Met carriers and SERT‐L' carriers. Thus, subjects were split into three groups: 1. High‐frequency susceptibility polymorphism group (hfSP, subjects with all three SPs); 2. Intermediate‐frequency SP group (ifSP, two SPs); and 3. Low‐frequency SP group (lfSP, one/none SP). Cortical thickness, volumetry of hippocampus, amygdala and subcortical structures, and white matter (WM) tract integrity were assessed. Compared to controls, hfSP patients showed thinning of the middle frontal cortex bilaterally, left frontal pole, and right lateral occipital cortex, and smaller hippocampal volume bilaterally; and both hfSP and lfSP patient groups showed thinning of the left inferior parietal cortex and reduced WM integrity of the corpus callosum. Compared to patients, hfSP controls showed greater integrity of the fronto‐occipital cortices and corpus callosum. We showed that cortical prefrontal and occipital damage of MDD patients is modulated by the SP accumulation, while damage to the parietal cortex and corpus callosum seem to be independent of genetic accumulation. HfSP controls may experience protective mechanisms leading to a preserved integrity of critical cortical and WM regions. Investigating the effect of multiple genes is promising to understand the pathological mechanisms underlying MDD. Hum Brain Mapp 37:2173–2184, 2016. © 2016 Wiley Periodicals, Inc.
Congestion control and user utility function for real-time traffic

Usage of multimedia communication in everyday life has seen a remarkable growth. Vast in Bandwidth demand often result in lower network performance and reduced quality of user experience during congestion. In this paper, we will address congestion control problem while providing quality of service (QOS) of delay for inelastic flows like video streaming, IPTV, etc. First, we propose an extension of an existing user utility function to capture user's satisfaction over bandwidth allocation, QoS, and the cost to acquire the service. Second, we will study the relationship between these three entities.
Grid infrastructure to support science portals for large scale instruments.

Soon, a new generation of scientific workbenches will be developed as a collaborative effort among various research institutions in the US. These scientific workbenches will be accessed in the Web via portals. Reusable components are needed to build such portals for different scientific disciplines, allowing uniform desktop access to remote resources. Such components will include tools and services enabling easy collaboration, job submission, job monitoring, component discovery, and persistent object storage. Based on experience gained from Grand Challenge applications for large-scale instruments, we demonstrate how Grid infrastructure components can be used to support the implementation of science portals. The availability of these components will simplify the prototype implementation of a common portal architecture.
ATTITUDES TOWARDS BENEFITS AND BEHAVIORAL INTENTIONS AND THEIR RELATIONSHIP TO ABSENTEEISM, PERFORMANCE, AND TURNOVER AMONG NURSES

The purpose of this study was to determine whether employees' attitudes towards benefits and behavioral intentions were related to nurse turnover, absenteeism, or on-the-job performance. Dramatic increases in the cost of benefits to employers, along with the need to attract and retain employees, have resulted in the requirement that the ramifications of employees' perceptions of benefits be better understood. Despite the fact that the literature is replete with studies involving pay equity and satisfaction, studies concerning the effects of perceived benefits are few. Attitudes towards benefits, intentions to search for a new job, to quit, to be absent, ratings of performance, and actual turnover – and absenteeism - were assessed using a sample of 386 nurses from a hospital in the Southwestern portion of the United States of America. The results of this study indicate that attitudes towards benefits are not predictive of absenteeism or performance and weak predictors of turnover. These findings are not consistent with the speculations of others (Mobley, 1982); that is, benefits perceptions may be instrumental in both the retention and attraction of employees. They are, however, consistent with previous findings when it comes to other populations that have lower turnover rates and see few options for moving up. Carraher and Buckley (2005) found that the ATBS dimensions were not related to turnover among entrepreneurs in Western Europe. On the other hand, Carraher (2006b) found that Ease of Replacement of Benefits was able to predict entrepreneurial turnover in Eastern Europe when the entrepreneurs were able to find options that would increase their incomes. It was surprising that while the behavioral intentions scales were significantly related to turnover, absenteeism, and performance the relationships were not very strong. When looking at practical significance or meaningfulness rather than at statistical significance, none of the relationships, while they are statistically significant, appear to be particularly meaningful suggesting that we should look elsewhere to explain turnover, absenteeism, and performance. The implications of these findings are discussed and areas for future research are presented.
Exosome-Related Multi-Pass Transmembrane Protein TSAP6 Is a Target of Rhomboid Protease RHBDD1-Induced Proteolysis

We have previously reported that rhomboid domain containing 1 (RHBDD1), a mammalian rhomboid protease highly expressed in the testis, can cleave the Bcl-2 protein Bik. In this study, we identified a multi-pass transmembrane protein, tumor suppressor activated pathway-6 (TSAP6) as a potential substrate of RHBDD1. RHBDD1 was found to induce the proteolysis of TSAP6 in a dose- and activity-dependent manner. The cleavage of TSAP6 was not restricted to its glycosylated form and occurred in three different regions. In addition, mass spectrometry and mutagenesis analyses both indicated that the major cleavage site laid in the C-terminal of the third transmembrane domain of TSAP6. A somatic cell knock-in approach was used to genetically inactivate the endogenous RHBDD1 in HCT116 and RKO colon cancer cells. Exosome secretion was significantly elevated when RHBDD1 was inactivated in the two cells lines. The increased exosome secretion was verfied through the detection of certain exosomal components, including Tsg101, Tf-R, FasL and Trail. In addition, the elevation of exosome secretion by RHBDD1 inactivation was reduced when TSAP6 was knocked down, indicating that the role of RHBDD1 in regulating exosomal trafficking is very likely to be TSAP6-dependent. We found that the increase in FasL and Trail increased exosome-induced apoptosis in Jurkat cells. Taken together, our findings suggest that RHBDD1 is involved in the regulation of a nonclassical exosomal secretion pathway through the restriction of TSAP6.
Open air market and mobile money information system requirements

Existing mobile money architectures overlooked value storage and everyday money practices of individuals. They mainly deal with payment related issues and procedures based on bank accounts. They also targeted urban people, who have banking and technology know-how. Based on this knowledge gap, this research intends to explore, analyze, and identify design concepts for mobile money information system development that can support rural communities in developing countries who transact in open air market. Majority of our study population cannot write and read even their names; they identify currency notes based on color and size not based on values written on them, which raises the question how could such illiterate rural individuals transact in electronic payment ecosystem. In this context, the purpose of this study is to thoroughly analyze and understand the characteristic nature of cash transactions and usage scenarios among study participants in open air market and identify design concepts and provoke discussions on this issue. Methodologically, we used qualitative methods, where data is collected through observation, discussions, and interview with key market participants and the data is documented through photograph and video. We found that almost all merchants: (1) use color of currencies to identify one from the other, (2) some merchants want to merge their sells while some want to keep their daily, (3) due to their transaction practices, merchants have many problems and make many errors and mistakes, (4) merchants who have no formal education expressed that they would like to have devices that operate by sound, and (5) sellers & buyers set prices of certain items through negotiation. The output of this study contributes towards the development of cashless transaction based on mobile phones.
Tests for Differentiation in Gene Expression Using a Data‐Driven Order or Weights for Hypotheses

In the analysis of gene expression by microarrays there are usually few subjects, but high‐dimensional data. By means of techniques, such as the theory of spherical tests or with suitable permutation tests, it is possible to sort the endpoints or to give weights to them according to specific criteria determined by the data while controlling the multiple type I error rate. The procedures developed so far are based on a sequential analysis of weighted p ‐values (corresponding to the endpoints), including the most extreme situation of weighting leading to a complete order of p ‐values. When the data for the endpoints have approximately equal variances, these procedures show good power properties.
Application protocol design considerations for a mobile internet

The Internet protocols were designed for a primarily "fixed" and relatively static network environment where communication links are stable and exhibit fairly uniform communication characteristics. Mobile wireless communication has fundamentally invalidated some of these assumptions, for (heterogeneous) wireless access networks and even more so for mobile ad-hoc networks (MA-NETs) formed between mobile users: from highly variable link characteristics to temporary disconnections to non-existing end-to-end paths. While many activities have focused on the link and network layer to provide seamless and ubiquitous connectivity for mobile users, thus mimicking the fixed Internet, and transport layer optimizations have addressed performance issues and connection persistence in wireless networks, application protocols have received rather little attention. However, the semantics of many of today's non-real-time applications are perfectly compatible with partly connected and disruptive mobile environments, it is just the protocol designs that are not. We identify issues with present application protocols and discuss requirements to make them workable in challenged mobile environments, leveraging Delay-tolerant Networking (DTN) as underlying communication paradigm and augmenting server-based operation by peer-to-peer communications.
Fluoxetine blocks cloned neuronal A-type K+ channels Kv1.4

The effects of fluoxetine were studied on cloned K+ channel Kv1.4 stably expressed in Chinese hamster ovary (CHO) cells using the whole-cell configuration of the patch-clamp technique. Extracellular application of various concentrations of fluoxetine inhibited the amplitude of the peak current of Kv1.4 and accelerated its inactivation time course in a concentration-dependent manner. Thus, fluoxetine decreased Kv1.4 (the integral of the outward current) in a concentration-dependent manner; the IC50 was 33.1 ± 2.5 μM. The inhibitory effect of fluoxetine was time-dependent. The apparent association (k) and dissociation (l) rate constants measured at +40 mV were 3.5 ± 0.7 μM−1s−1 and 132.5 ± 13.3 s−1, respectively. The Kd (= l/k) was 37.9 μM, which was close to the value obtained from the concentration–response curve. The block produced by fluoxetine increased steeply between −30 and 0 mV, which corresponded with the voltage range for channel opening. The fluoxetine block was constant at more depolarized potentials, suggesting that the block by fluoxetine was not voltage dependent. Our data indicate that fluoxetine blocks Kv1.4 channels by preferentially binding to open state.
Selecting an Optimum Configuration of One-Way and Two-Way Routes

The problem of designing a near optimal configura­ tion of a system of one-way and two-way routes is investigated. Each arc of the network can be designed as either a two-way arc or a one­ way arc in one of the two directions. The traffic speed on a one-way arc is faster than the speed on a two-way arc by a given factor. The problem is to design a network which minimizes total travel time between all pairs of nodes by the proper selection of one-way and two-way arcs. Efficient implementations of the metaheuristic tabu search are designed for solving this network design problem. These approaches are tested on a set of network problems with encouraging results.
Efficient and practical Newton solvers for non-linear Stokes systems in geodynamic problems

Many problems in geodynamic modelling result in a non-linear Stokes problem in which the viscosity depends on the strain rate and pressure (in addition to other variables). After discretization, the resulting non-linear system is most commonly solved using a Picard fixedpoint iteration. However, it is well understood that Newton's method - when augmented by globalization strategies to ensure convergence even from points far from the solution - can be substantially more efficient and accurate than a Picard solver. In this contribution, we evaluate how a straightforward Newton method must be modified to allow for the kinds of rheologies common in geodynamics. Specifically, we show that the Newton step is not actually well posed for strain rate-weakening models without modifications to the Newton matrix. We derive modifications that guarantee well posedness and that also allow for efficient solution strategies by ensuring that the top left block of the Newton matrix is symmetric and positive definite.We demonstrate the applicability and relevance of thesemodifications with a sequence of benchmarks and a test case of realistic complexity.