Miracle-dz/UniFAR-FTUs huggingface dataset:
Empirical Modeling of Education Expenditures for Balkans: Evidence from Panel FMOLS and DOLS Estimations

The focal point of this study is to investigate the possible determinants of public education expenditures for Balkan countries. Panel cointegration, FMOLS, DOLS, panel causality tests have been conducted throughout this study. The empirical findings reveal that GDP per capita income, economic stability, school enrolments and technological development are found to be the main determinants which have dynamic significant relationships on public education expenditures in the long-run. Dumitrescu-Hurlin panel causality test with individual coefficients mirror (i) bi-directional causalities between education expenditures and school enrolments and between education expenditures and GDP per capita income; (ii) unidirectional causalities running from technological development to education expenditures and from education expenditures to financial risk.
Validity of a self-administered diet history questionnaire for estimating vitamin D intakes of Japanese pregnant women.

Maternal vitamin D status is important for fetal development and the prevention of pregnancy complications. Mothers require both sufficient intakes and skin production of this vitamin. We investigated the validity and test-retest reliability of a self-administered diet history questionnaire (DHQ) to establish a method of assessing vitamin D intakes of Japanese pregnant women, using a serum marker. A total of 245 healthy pregnant women in the second trimester, who were not taking vitamin D supplements, were recruited at a university hospital in Tokyo between June 2010 and July 2011. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured as an indicator of vitamin D status. To assess the test-retest reliability of the DHQ, 58 pregnant women completed it twice within a 4-5-week interval. Significant positive correlations between intakes and serum concentrations of vitamin D were found (r = 0.266 for daily intakes and r = 0.249 for energy-adjusted intakes). In the winter investigation in which the serum 25(OH)D concentrations were less likely to be affected by sunlight exposure, the correlation coefficients were 0.304 for both daily and energy-adjusted intakes. After excluding participants with pregnancy-associated nausea, the coefficients increased. The intraclass correlation coefficient between vitamin D intakes estimated from the two-time DHQ was 0.638. The DHQ provides an acceptable validity and reliability of the vitamin D intake of Japanese pregnant women. However, the data of women with nausea should be interpreted with caution. We believe that the DHQ is a useful questionnaire to grasp and improve vitamin D intakes during pregnancy.
Diversification in a fluctuating island setting: rapid radiation of Ohomopterus ground beetles in the Japanese Islands

The Japanese Islands have been largely isolated from the East Asian mainland since the Early Pleistocene, allowing the diversification of endemic lineages. Here, we explore speciation rates and historical biogeography of the ground beetles of the subgenus Ohomopterus (genus Carabus) based on nuclear and mitochondrial gene sequences. Ohomopterus diverged into 15 species during the Pleistocene. The speciation rate was 1.92 Ma–1 and was particularly fast (2.37 Ma–1) in a group with highly divergent genitalia. Speciation occurred almost solely within Honshu, the largest island with complex geography. Species diversity is highest in central Honshu, where closely related species occur parapatrically and different-sized species co-occur. Range expansion of some species in the past has resulted in such species assemblages. Introgressive hybridization, at least for mitochondrial DNA, has occurred repeatedly between species in contact, but has not greatly disturbed species distinctness. Small-island populations of some species were separated from main-island populations only after the last glacial (or the last interglacial) period, indicating that island isolation had little role in speciation. Thus, the speciation and formation of the Ohomopterus assemblage occurred despite frequent opportunities for secondary contact and hybridization and the lack of persistent isolation. This radiation was achieved without substantial ecological differentiation, but with marked differentiation in mechanical agents of reproductive isolation (body size and genital morphology).
STAT4 Deficiency Fails To Induce Lung Th2 or Th17 Immunity following Primary or Secondary Respiratory Syncytial Virus (RSV) Challenge but Enhances the Lung RSV-Specific CD8+ T Cell Immune Response to Secondary Challenge

ABSTRACT Immune-mediated lung injury is a hallmark of lower respiratory tract illness caused by respiratory syncytial virus (RSV). STAT4 plays a critical role in CD4+ Th1 lineage differentiation and gamma interferon (IFN-γ) protein expression by CD4+ T cells. As CD4+ Th1 differentiation is associated with negative regulation of CD4+ Th2 and Th17 differentiation, we hypothesized that RSV infection of STAT4−/− mice would result in enhanced lung Th2 and Th17 inflammation and impaired lung Th1 inflammation compared to wild-type (WT) mice. We performed primary and secondary RSV challenges in WT and STAT4−/− mice and used STAT1−/− mice as a positive control for the development of RSV-specific lung Th2 and Th17 inflammation during primary challenge. Primary RSV challenge of STAT4−/− mice resulted in decreased T-bet and IFN-γ expression levels in CD4+ T cells compared to those of WT mice. Lung Th2 and Th17 inflammation did not develop in primary RSV-challenged STAT4−/− mice. Decreased IFN-γ expression by NK cells, CD4+ T cells, and CD8+ T cells was associated with attenuated weight loss and enhanced viral clearance with primary challenge in STAT4−/− mice compared to WT mice. Following secondary challenge, WT and STAT4−/− mice also did not develop lung Th2 or Th17 inflammation. In contrast to primary challenge, secondary RSV challenge of STAT4−/− mice resulted in enhanced weight loss, an increased lung IFN-γ expression level, and an increased lung RSV-specific CD8+ T cell response compared to those of WT mice. These data demonstrate that STAT4 regulates the RSV-specific CD8+ T cell response to secondary infection but does not independently regulate lung Th2 or Th17 immune responses to RSV challenge. IMPORTANCE STAT4 is a protein critical for both innate and adaptive immune responses to viral infection. Our results show that STAT4 regulates the immune response to primary and secondary challenge with RSV but does not restrain RSV-induced lung Th2 or Th17 immune responses. These findings suggest that STAT4 expression may influence lung immunity and severity of illness following primary and secondary RSV infections.
Conformal integration of traveling-wave slot antennas in millimeter-wave regime

A design of feeding transition for conformal integration of traveling-wave slot antennas in the millimeter-wave regime is presented in this paper. The design utilizes a shielded half-mode substrate-integrated waveguide (HMSIW) bent section to provide an efficient transition from a coaxial connector to the antenna. A curved ground plane, such as the surface of a cylindrical pole, mimics an infinite ground plane and thus minimizes ripples in the azimuth-plane radiation pattern. The design is demonstrated with two antenna applications, including a wideband broad beam antenna and a directive leaky-wave antenna with minimized sidelobe level.
Spherical Blurred Shape Model for 3-D Object and Pose Recognition: Quantitative Analysis and HCI Applications in Smart Environments

The use of depth maps is of increasing interest after the advent of cheap multisensor devices based on structured light, such as Kinect. In this context, there is a strong need of powerful 3-D shape descriptors able to generate rich object representations. Although several 3-D descriptors have been already proposed in the literature, the research of discriminative and computationally efficient descriptors is still an open issue. In this paper, we propose a novel point cloud descriptor called spherical blurred shape model (SBSM) that successfully encodes the structure density and local variabilities of an object based on shape voxel distances and a neighborhood propagation strategy. The proposed SBSM is proven to be rotation and scale invariant, robust to noise and occlusions, highly discriminative for multiple categories of complex objects like the human hand, and computationally efficient since the SBSM complexity is linear to the number of object voxels. Experimental evaluation in public depth multiclass object data, 3-D facial expressions data, and a novel hand poses data sets show significant performance improvements in relation to state-of-the-art approaches. Moreover, the effectiveness of the proposal is also proved for object spotting in 3-D scenes and for real-time automatic hand pose recognition in human computer interaction scenarios.
Respiratory gating for 3-dimensional PET of the thorax: feasibility and initial results.

UNLABELLED Respiratory motion may reduce the sensitivity of (18)F-FDG PET for the detection of small pulmonary nodules close to the base of the lungs. This motion also interferes with attempts to use fused PET/CT images through software or combined PET/CT devices. This study was undertaken to assess the feasibility of respiratory gating for PET of the chest and the impact of respiratory motion on quantitative analysis. METHODS Ten healthy subjects were enrolled in this study. Three-dimensional studies were acquired with 8 gates per respiratory cycle on a commercial PET scanner with a temperature-sensitive respiratory gating device built in-house. All scans were obtained over 42 cm of body length with 3 bed positions of 10 min each after injection of (18)F-FDG at 4.5 MBq/kg. The reconstructed images were assembled to produce gated whole-body volumes and maximum-intensity projections. The amplitude of respiratory motion of the kidneys (as a surrogate for diaphragmatic incursion) as well as the apex of the heart was measured in the coronal plane. Phantom studies were acquired to simulate the impact of respiratory motion on quantitative uptake measurements. RESULTS The respiratory gating device produced a consistent, reliable trigger signal. All acquisitions were successful and produced reconstructed volumes with excellent image quality. Mean +/- SD motion amplitude and maximal motion amplitude values were 6.7 +/- 3.0 and 11.9 mm for the heart, 12.0 +/- 3.7 and 18.8 mm for the right kidney, and 11.1 +/- 4.8 and 17.1 mm for the left kidney, respectively. In phantom studies, the standardized uptake value for a 1-mL lesion was underestimated by 30% and 48% for the average and maximal respiratory motion values, respectively. CONCLUSION Respiratory gating of PET of the thorax and upper abdomen is a practical and feasible approach that may improve the detection of small pulmonary nodules. Further work is planned to assess prospectively the diagnostic accuracy of this new method.
Additional Discoveries on Causes of Teacher Attrition

The purpose of this research was to explore additional causes of teacher attrition different from the conventional causes as identified by many literatures around the world. A qualitative method was used. Six serving teachers in two urban secondary schools in Niger state, Nigeria were purposively sampled, an in depth interview and document analysis was used as a means of data collection. The findings discovered; late payment of salary, irregular promotion, and Language problem among students, as the additional causes of teacher attrition. The paper concludes that teacher attrition is affected by the three major factors identified from the studyand these factors give the impression that teaching profession is not respected as other government profession in the study area hence their welfare was not given a due consideration.
Effects of Oxygen and Heme on the Development of a Microbial Respiratory System

The effect of adding hemin to anaerobically grown cells of a strain of Staphylococcus epidermidis, which was heme-deficient due to anaerobic growth, has been examined. Cells grown anaerobically in media containing hemin exhibited a marked increase in several oxidative activities as compared with cells grown anaerobically without hemin. The respiratory activity of whole cells and a cyamide-sensitive reduced nicotinamide adenine dinucleotide oxidase activity of cell-free extracts were increased fourfold. The content of enzymatically reducible pigments which exhibit difference spectra similar to cytochromes b1 and o was also markedly increased. These pigments are mostly sedimented at 100,000 × g (1 hr). Hemin also caused a marked increase in respiratory activity when added directly to the anaerobic culture after the period of growth, but did not cause a similar increase in respiration when added to washed, resting-cell suspensions. Under the latter conditions, heme pigments were formed which exhibited difference spectra similar to, but not identical with, the spectra of pigments found in anaerobic cells grown in the presence of hemin. When resting suspensions of cells grown anaerobically without hemin were exposed to air, a rapid fourfold increase in respiratory activity and a limited increase in cytochrome-like pigments occurred. The presence of the heme precursor Δ-aminolevulinic acid during this aeration resulted in a rapid and marked increase in heme pigments, but only a slight stimulation of respiratory activity. The possible implications of these results for the roles which heme and oxygen play in the development of the respiratory system of this organism are discussed.
The IQGAP1 Protein Is a Calmodulin-regulated Barbed End Capper of Actin Filaments

IQGAP1 is a large modular protein that displays multiple partnership and is thought to act as a scaffold in coupling cell signaling to the actin and microtubule cytoskeletons in cell migration, adhesion, and cytokinesis. However the molecular mechanisms underlying the activities of IQGAP1 are poorly understood in part because of its large size, poor solubility and lack of functional assays to challenge biochemical properties in various contexts. We have purified bacterially expressed recombinant human IQGAP1. The protein binds Cdc42, Rac1, and the CRIB domain of N-WASP in a calmodulin-sensitive fashion. We further show that in addition to bundling of filaments via a single N-terminal calponin-homology domain, IQGAP1 actually regulates actin assembly. It caps barbed ends, with a higher affinity for ADP-bound terminal subunits (KB = 4 nm). The barbed end capping activity is inhibited by calmodulin, consistent with calmodulin binding to IQGAP1 with a KC of 40 nm, both in the absence and presence of Ca2+ ions. The barbed end capping activity resides in the C-terminal half of IQGAP1. It is possible that the capping activity of IQGAP1 accounts for its stimulation of cell migration. We further find that bacterially expressed recombinant IQGAP1 fragments easily co-purify with nucleic acids that turn out to activate N-WASP protein to branch filaments with Arp2/3 complex. The present results open perspectives for tackling the function of IQGAP1 in more complex reconstituted systems.
Bedside Ultrasound in the Intensive Care Unit: Where Is the Evidence?

Abstract Interest in bedside ultrasound in the intensive care unit and emergency department has exploded in recent years. This interest is driven in part by the utility of ultrasound for procedural guidance. In most cases, enthusiasm outstrips current evidence. While ultrasound is often felt to be risk-free, the important risk of ultrasound is the chance of false diagnosis. The vividness of visual images may make practitioners especially prone to cognitive errors in interpretation. Possible applications of ultrasound include management of shock and respiratory failure, two complex syndromes with multiple aspects. Reasonable evidence supports use of ultrasound to guide volume expansion, although its value remains to be demonstrated in an explicit protocol. Other possibilities include ventilator titration and guidance of diuresis. While the literature is more complicated, there is some early evidence that lung ultrasound may improve the diagnosis of dyspnea, although these results have not been well validated. Centers should avoid premature loss of equipoise and participate in studies of explicit protocols that incorporate ultrasound.
Performance Analysis of Millimeter-Wave Phased Array Antennas in Cellular Handsets

This letter discusses the usage of high-gain steerable antenna arrays operating at millimeter-wave (mmWave) frequencies for future cellular networks (5G). Based on the probable outline of the 5G networks, a method for characterizing phased array antennas in cellular handsets has been introduced. For analyzing the performance, the total scan pattern of the array configuration together with its respective coverage efficiency are essential to consider in order to compare different antenna designs and topology approaches with each other. Two design approaches and subarray schemes of these have been considered in order to illustrate the relevance of such a characterization method. The results show the importance of evaluating potential array antennas in such manners. The method can be applied to much more complex system models, where polarization diversity, hand and body effect, and statistical modeling of the channel may be included.
The Role of Meaning in Advanced Cancer—Integrating the Constructs of Assumptive World, Sense of Coherence and Meaning-Based Coping

Abstract This study used qualitative methods to elicit the thoughts and attitudes of patients with advanced cancer. Our two interrelated aims were to explore how participants experience and apply meaning; and to consider whether this experience can be understood within an integrated framework of assumptive world (AW), sense of coherence (SOC) and meaning-based coping (MBC). Using semi-structured interviews, 26 conversations were held overall with 10 participants. Transcriptions were analysed for themes of lived-experience and for evidence of the principal elements of AW, SOC, and MBC. Findings suggest three interrelated domains that form an adaptive pathway towards coherence and sense of self. While this pathway is essentially linear it is also responsive to the ongoing stressful nature of advanced cancer.
Quantitative EBV Viral Loads and Immunosuppression Alterations can Decrease PTLD Incidence in Pediatric Liver Transplant Recipients

Epstein–Barr virus (EBV) is a common viral infection in pediatric liver transplant patients and can lead to development of post‐transplant lymphoproliferative disorder (PTLD). Differing studies have used immunosuppression reduction, antiviral medications or i.v. CMV‐immunogloublin for EBV prevention and treatment. The purpose of this study was to determine whether implementation of a protocol for frequent EBV monitoring and EBV viral load‐driven immunosuppression reduction could decrease the incidence of PTLD in our patient population. All data were prospectively collected between 2001 and 2004 at a single institution. Seventy‐three patients were entered into the study. Patients were divided into a historical control group (pre‐2001, 30 patients) and a treatment group (post‐2001, 43 patients). Approximately 1271 blood samples of 73 patients were collected between 2001 and 2004. Eleven out of 43 patients received immunosuppression tapering due to high EBV viral loads (>4000 copies/μg DNA). One patient developed allograft rejection after immunosuppression modulation. Prior to 2001, the incidence of PTLD at our institution was 16%. After instituting a protocol for EBV monitoring, the incidence of PTLD decreased to 2% (p‐value < 0.05). These findings illustrate that frequent EBV viral load monitoring and preemptive immunosuppression modulation have an integral role in preventing PTLD in the pediatric liver transplant population.
Crowdfunding Innovative Ideas: How Incremental and Radical Innovativeness Influence Funding Outcomes

We investigate the effect of innovativeness on crowdfunding outcomes. Because crowdfunding campaigns characterized by greater incremental innovativeness are more comprehensible and generate more user value for typical crowdfunders, incremental innovativeness may result in more favorable funding outcomes. By comparison, campaigns that feature greater radical innovativeness are riskier to develop, harder for crowdfunders to understand and result in less favorable funding outcomes. This negative effect of radical innovativeness may be mitigated by incremental innovativeness, which may help crowdfunders to understand and appreciate radical innovativeness more. A sample of 334 Kickstarter campaigns provides support for our hypotheses.
Mixed Maximal and Explosive Strength Training in Recreational Endurance Runners

Abstract Taipale, RS, Mikkola, J, Salo, T, Hokka, L, Vesterinen, V, Kraemer, WJ, Nummela, A, and Häkkinen, K. Mixed maximal and explosive strength training in recreational endurance runners. J Strength Cond Res 28(3): 689–699, 2014—Supervised periodized mixed maximal and explosive strength training added to endurance training in recreational endurance runners was examined during an 8-week intervention preceded by an 8-week preparatory strength training period. Thirty-four subjects (21–45 years) were divided into experimental groups: men (M, n = 9), women (W, n = 9), and control groups: men (MC, n = 7), women (WC, n = 9). The experimental groups performed mixed maximal and explosive exercises, whereas control subjects performed circuit training with body weight. Endurance training included running at an intensity below lactate threshold. Strength, power, endurance performance characteristics, and hormones were monitored throughout the study. Significance was set at p ⩽ 0.05. Increases were observed in both experimental groups that were more systematic than in the control groups in explosive strength (12 and 13% in men and women, respectively), muscle activation, maximal strength (6 and 13%), and peak running speed (14.9 ± 1.2 to 15.6 ± 1.2 and 12.9 ± 0.9 to 13.5 ± 0.8 km Ł h−1). The control groups showed significant improvements in maximal and explosive strength, but Speak increased only in MC. Submaximal running characteristics (blood lactate and heart rate) improved in all groups. Serum hormones fluctuated significantly in men (testosterone) and in women (thyroid stimulating hormone) but returned to baseline by the end of the study. Mixed strength training combined with endurance training may be more effective than circuit training in recreational endurance runners to benefit overall fitness that may be important for other adaptive processes and larger training loads associated with, e.g., marathon training.
Ca2+/calmodulin‐dependent protein kinase IIα clusters are associated with stable lipid rafts and their formation traps PSD‐95

Relatively large number of post‐synaptic density (PSD) proteins, including Ca2+/calmodulin‐dependent protein kinase II (CaMKII), have the potential to associate with lipid rafts. We in this study demonstrate that the CaMKIIα clusters induced by ionomycin in human embryonic kidney 293 cells, as well as unclustered CaMKIIα (Du F., Saitoh F., Tian Q. B., Miyazawa S., Endo S. and Suzuki T, 2006, Biochem. Biophys. Res. Commun 347, 814–820), were associated with lipid rafts. The CaMKIIα clusters associated with lipid raft fraction became resistant to treatment with methyl‐β‐cyclodextrin and subsequent cold Triton X‐100, which suggests the stabilization of CaMKIIα cluster‐associated lipid rafts. Next, we found that PSD‐95, which is also a component of lipid raft fraction and does not interact directly with CaMKII, was trapped by stable CaMKIIα cluster‐containing structure. Association of PSD‐95 with CaMKIIα clusters was also observed in cultured neuronal cells. These results suggest the CaMKIIα clusters associated with the lipid rafts in the cytoplasmic region play a role in the assembly and stabilization of certain PSD proteins that have the potential to associate with lipid rafts.