Miracle-dz/UniFAR-FTUs huggingface dataset:
A CMOS sensor platform with 1.2 µm × 2.05 µm electroless-plated 1024 × 1024 microelectrode array for high-sensitivity rapid direct bacteria counting

A CMOS sensor platform with a bacteria-sized (1.2 μm × 2.05 μm) Au electroless-plated 1024 × 1024 microelectrode array for high-sensitivity rapid direct bacteria counting is demonstrated. For high-sensitivity direct pathogen counting, Au microelectrodes are required to be as small as the target cell. In this work, by improving a self-aligned electroless plating technique, the size of microelectrodes on a CMOS sensor chip was successfully reduced to 1.2 μm × 2.05 μm, corresponding to 1/20th of the smallest size reported in literature. Two test chips with 1024 × 1024 and 32 × 32 sensor arrays were fabricated in a 0.6-μm CMOS process and microelectrodes were formed on them using electroless plating. The uniformity among the 1024 × 1024 electrodes arranged with a pitch of 3.6 μm × 4.45 μm was optically verified. In addition, the trenches on each microelectrodes for improving sensitivity were developed and optically verified for the first time. Cyclic voltammetry (CV) measurements made using the 32 × 32 sensor array chip with 6-μm square electroless-plated microelectrodes successfully demonstrated the platform's effectiveness in the direct counting of HeLa cells.
Planning user assignment in administrative role-based access control

By introducing prerequisite conditions into the User-Role Assignment component (URA), Administrative Role-Based Access Control model (ARBAC) has decentralized the user-role assignment without losing the centralized control on security policies. However, in a large-scale Role-Based Access Control (RBAC) system, employing the URA makes it very difficult to manually obtain a sequence of the administrative operators by which a given user can be assigned to a given role. We refer to this problem as the User Assignment Problem (UAP). We formalized the UAP and recognized the UAP as an exponential space complexity problem. We also presented a graph-based search technology to solve the UAP, which was shown to be practically feasible in large-scaled RBAC systems.
Development of Methanol Sensor Using SH-SAW Sensor for Direct Methanol Fuel Cell

A methanol sensor for direct methanol fuel cell (DMFC) is required. A shear horizontal surface acoustic wave (SH-SAW) sensor for electrical property detection is applied for it. The operative temperature of DMFC is above 50degC. The wave propagation characteristics are calculated with considering temperature coefficient. The results indicate that the sensitivity increases with the temperature. Methanol solutions are measured using the SH-SAW sensor. Linear relationships between the sensor response and concentration were obtained. Also, the increase of the sensitivity is experimentally confirmed. As a formic acid is produced in DMFC, mixture solutions of methanol and formic acid were measured. Using coordinate transformation, it is possible to estimate methanol concentration in mixture solution.
ACCESSIBILITY, FINANCIAL RISK PERCEPTION AND FARMERS’ SATISFACTION TO MICROFINANCE SERVICES QUALITY IN DEVELOPING COUNTRIES

Government provides many farming finance loan programs to farming community, but many farmers still feel that financial institutions that are given trust by the government are difficult to access. Thus, this study aims: first, to reveal farmers 'assumptions about accessibility, secondly to analyze risk perceptions of micro finance and the final goal is to analyze whether microfinance services can satisfy farmers' needs. This research was conducted on two groups of farmers, such as rice farmers in Singosari District and orange farmers in Dau District, Malang Regency, East Java Province, Indonesia. Data analysis method uses quantitative descriptive, with the use of farmer perceptions scoring regarding accessibility dimensions, namely affordability, impact and sustainability, and perception of financial risk, while service quality dimensions are Tangibles, Reliability, Responsiveness, Assurance, Emphaty by using SEM-PLS analysis. Both rice farmers and orange farmers have good accessibility, but there are differences in the actions of borrowing funds from the two groups of farmers. Rice farmers do not dare to borrow funds if they have not coordinated with farmers’ group association, while orange farmers dare to borrow individually. At present, farmers are getting a loan from one of the government programs, and the results of the study indicate that the risk is very low if borrowing is done through a farmers’ group association. While the results of the analysis of the quality of microfinance services that are closely related to the satisfaction of orange farmers as borrowing customers are the dimensions of Reliability, Assurance and Emphaty. Although the service dimensions are positively related to satisfaction, there are several indicators that microfinance must improve so that farmers are more satisfied with the government programs mandated by the institution. Indicators that must be corrected by microfinance are employees 'knowledge of government programs in detail and giving more attention to farmers' customers.
A data-driven design of optimal ILC for nonlinear systems

This paper presents a new data-driven optimal design framework of iterative learning control (ILC) for a class of general nonlinear systems. The presented data-driven optimal ILC consists of a control input iterative updating law and a gradient matrix iterative estimate law based on two quadratic criterions, respectively. A major contribution of the presented optimal ILC mechanism is that it only uses the real-time measured I/O data without any model information of the plant for the controller design and analysis. Rigorous mathematical analysis is developed to illustrate the effecience of the proposed approaches.
Reflected wave spectrum analysis for estimation of earth subsurface fluid properties

In exploration geophysics, one of the major techniques of estimating the properties of the EarthpsilaS subsurface is reflection seismology. In this method, a seismic source of energy - wideband pulses produced by dynamite or a specialized air gun, or a narrow band chirp signal - is used to send waves into the earthpsilas interior. An array of receiver - typically geophones or hydrophones - suitably placed in a grid pattern, receives the reflected and refracted seismic waves, which travel through earth layers. Based on the timing and content of these received waves, the properties of the Earth are estimated.
SPEC HPG benchmarks for high-performance systems

In this paper, we discuss the results and characteristics of the benchmark suites maintained by the Standard Performance Evaluation Corporation's (SPEC) High-Performance Group (HPG). Currently, SPECHPGhas two lines of benchmark suites for measuring performance of large-scale systems SPEC OMP and SPEC HPC2002. SPEC OMP uses the OpenMP API and includes benchmark suites intended for measuring performance of modern shared memory parallel systems. SPEC HPC2002 uses both OpenMP and MPI, and thus it is suitable for distributed memory systems, shared memory systems and hybrid systems. SPEC HPC2002 contains benchmarks from three popular application areas: chemistry, seismic and weather forecasting. Each of the three benchmarks in HPC2002 has a small and a medium data set in order to satisfy the need for benchmarking a wide range of high-performance systems. We analyse published results of these benchmark suites regarding scalability. We also present current efforts of SPEC HPG to create new releases of the benchmark suites.
Identification and characterization of an irreversible inhibitor of CDK 2

http://sro.sussex. ac.uk Anscombe, Elizabeth, Meschini, Elisa, Mora-Vidal, Regina, Martin, Mathew P, Staunton, David, Geitmann, Matthis, Danielson, U Helena, Stanley, Will A, Wang, Lan Z, Reuillon, Tristan, Golding, Bernard T, Cano, Celine, Newell, David R, Noble, Martin E M, Wedge, Stephen R et al. (2015) Identification and characterization of an irreversible inhibitor of CDK2. Chemistry & Biology, 22 (9). pp. 1159-1164. ISSN 1074-5521
The objective structured clinical examination: a step in the direction of competency-based evaluation.

BACKGROUND The Accreditation Council for Graduate Medical Education is embarking on the major task of a paradigm shift in graduate education in the direction of competency-based medical education and evaluation of outcomes. The Objective Structured Clinical Examination (OSCE), a measure of clinical competence that focuses on outcomes via observable behaviors, is gaining national recognition. OBJECTIVE To review the pediatric literature relevant to the OSCE. METHOD A MEDLINE search from the date of the original report of the OSCE (1975) to the present was performed. All English-language studies regarding the use of the OSCE in pediatric education published in the United States and Great Britain were reviewed. MAIN OUTCOME MEASURES Reliability and validity of the OSCE were examined. Use of standardized pediatric patients was discussed. RESULTS A greater number of stations and similarity between tasks at different stations increased the reliability of the OSCE. A greater number of stations increased sampling of material and content validity. Correlation between the OSCE and precertification examinations ranged between 0.59 and 0.71, with P< or =. 01. Correlation between the OSCE and monthly clinical evaluations was much lower (0.39-0.57), but still statistically significant at P< or =. 05. Gaps between expected and actual performance were documented. Overall, the experience of being a standardized patient was viewed as positive by children and their parents. CONCLUSIONS With appropriate attention to design, acceptable reliability and validity can be achieved for the OSCE. Significant correlations between the OSCE and precertification examinations as well as monthly clinical evaluations were found, the former being stronger than the latter. We conclude that the combination of the OSCE, standardized board examinations, and direct observation in the clinical setting has the potential to become the "gold standard" for measuring physician competence.
Morphological predictors of swimming speed: a case study of pre-settlement juvenile coral reef fishes

SUMMARY The swimming abilities of fishes are of vital importance to their ecology, and studies on fish swimming have been the focus of research for over a century. Here we explore the relationship between swimming ability and external body morphology, using data on Ucrit swimming speeds of 100 species of pre-settlement juvenile coral reef fishes (at the transition between the larval and adult habitats), comprising 26 different families from 5 orders. The taxonomic diversity of this methodologically consistent dataset provides a unique opportunity to examine the relationship between form and function in fish swimming across a broad taxonomic range. Overall, we found that a predictive model incorporating total length (TL), the square of caudal peduncle depth factor (CPDF2) and aspect ratio (AR) can be used to accurately predict swimming performance of a wide range of fish families, and was able to explain 69% of the variability in swimming performance of these pre-settlement juvenile fishes. The model was also able to successfully predict the swimming speed of an out-group salmonid species (Oncorhynchus mykiss). There was no evidence that the model fit differed among taxonomic groups, despite the inclusion of five different orders of fishes, suggesting that body morphology sufficiently explains the bulk of differences in swimming performance. Furthermore, the model appears to work equally well for fishes from the Great Barrier Reef and the Caribbean, and for families with different adult habitat associations and swimming modes. It remains to be determined how well the model predicts the swimming abilities of temperate species as well as adults of these same species. This model provides an invaluable means of predicting swimming abilities of pre-settlement juvenile fishes that are unable to be reared in the laboratory, do not perform well in swimming flumes or are unable to be captured live in the field.
Creativity and Schizophrenia: An Equality of Empirical Constructs

Summary The possibility that schizophrenia and creativity are two aspects of the same process is discussed, and parallels between different types of schizophrenia and different factors of creativity are sought. The discussion begins at a theoretical level, but its main thrust is an analysis of the research literature at an empirical level. Similarities are pointed out between tasks used for the purpose of operationally defining the schizophrenic ‘deficit’ and tasks used to define creativity. Some evidence is found for different subtypes of schizophrenics exhibiting different factors or types of creativity.
Blood glucose control in the ICU: how tight?

Fifteen years after the first randomized controlled trial (RCT) on tight blood glucose control (TGC) in the intensive care unit (ICU), the exact target of blood glucose control remains a matter of debate, especially since subsequent RCTs have found divergent results (1-4). Indeed, whereas the Leuven RCTs found that targeting normal for age fasting blood glucose levels with insulin clearly reduced short-term morbidity and mortality in critically ill adults and children (1-3), with the benefit maintained on the long term (5,6), the largest multicenter RCT (NICE-SUGAR) found excess mortality (4), which was attributed to an increased risk of severe hypoglycemia (7).
Meets the Internet : Web-based Surveys in the Millennium Cohort Study

Almost 60% of American households were connected to the Internet in 2001, when the Millennium Cohort Study, the largest longitudinal study ever undertaken by the Department of Defense, was launched. To facilitate survey completion, increase data integrity, and encourage cohort retention while maintaining the highest standards of participant privacy, an online questionnaire was made available on the World Wide Web in addition to a traditional paper questionnaire sent via US mail. Over 50% of 77,047 participants chose to enroll in the study via the Web, affording substantial cost savings to the project. Using multivariable logistic regression, the authors compared the demographic and health characteristics of Web responders with those of paper responders. Web responders were slightly more likely to be male, to be younger, to have a high school diploma or college degree, and to work in information technology or another technical occupation. Web responders were more likely to be obese and to smoke more cigarettes and were less likely to be problem alcohol drinkers and to report occupational exposures. Question completion rates were 98.3%, on average, for both Web and paper responders. Web responders provided more complete contact information, including their e-mail addresses. These results demonstrate the value of survey research conducted over the Internet in concert with traditional mail survey strategies.
Etalonnage geometrique des robots paralleles

Les tolerances de fabrication et d'assemblage d'un robot parallele sont, en grande partie, responsables de la mauvaise estimation des parametres geometriques qui definissent la modelisation du manipulateur. Ces erreurs affectent la commande et deteriorent la precision de positionnement du robot. Afin de remedier a ce probleme, il est necessaire de proceder a l'etalonnage du manipulateur ; c'est a dire identifier les parametres geometriques a l'aide d'informations fournies par des mesures internes (obtenues grace aux capteurs proprioceptifs) et eventuellement externes (obtenues a travers une machine a mesurer). Apres avoir presente les methodes courantes de l'etalonnage des robots paralleles et les moyens de rendre les resultats plus robustes par rapport aux erreurs de mesures, cette these presente plusieurs contributions originales. Tout d'abord, deux solutions algebriques sont proposees pour resoudre le systeme d'equation de base de l'etalonnage. Puis, une etude sur l'ajout de contrainte sur l'organe terminal ou sur les segments du robot montre que nous pouvons utiliser ces contraintes, soit pour ameliorer les resultats, soit pour simplifier la mise en uvre experimentale (suppression totale ou partielle des mesures externes). Une derniere methode est enfin presentee afin d'auto-etalonner le manipulateur parallele dans un cadre industriel, ceci dans le cas ou des capteurs supplementaires sont installes sur la structure du robot. Les methodes sont validees par simulation et discutees.
CLARIFICATION OF PUBLIC TRANSPORT USAGE CONDITIONS IN AHMEDABAD, INDIA

Ahmedabad, India, has serious traffic congestion problems in peak periods. This is mainly due to the use of cars and motorcycles. The usage of public transport, consisting of a bus system called “AMTS” and a rapid transit bus called “BRTS”, represented only a 12% modal share in Ahmedabad in 2011. This study explores the conditions underlying the non-use of public transport and its feeders among car and motorcycle owners in Ahmedabad. We conducted a household questionnaire survey that gathers respondents’ subjective impressions of public transport and its feeder services in the suburban areas of Ahmedabad in December 2017. A Transport Unacceptance Model is developed based on the Technology Acceptance Model 2 using structural equation modelling based on the collected samples. We reveal that the “no advantage to use” among the owners of cars and motorcycles has the highest effect on the non-use of AMTS among the latent variables, followed by “burden to use”. The observed variables “effort to transfer” and “effort of route choice” significantly affect the “burden to use” latent variable. “Burden to use” regarding auto-rickshaws has a relatively strong effect on the non-use of AMTS. This implies that improving feeder services (i.e. the connectivity between auto-rickshaws and AMTS) is important for enhancing the use of AMTS. As for BRTS, “burden to use public transport (i.e. ticketing system)” and “auto-rickshaw” have the strongest effects among the latent variables. Several negative impressions of auto-rickshaws as a feeder service are observed in both AMTS and BRTS. Particularly, subjective norms such as “family and friends do not use auto-rickshaw” are influential on the non-use of public transport.
Coevolved cognitive mechanisms in mate search : Making decisions in a decision-shaped world

I magine that you are driving to a movie theater to watch a film. You look for a place to park as you approach the cinema, and show time is coming up. You feel some time pressure not to miss all the previews, and you are motivated to try to minimize your total travel time, including driving and then walking from wherever you park. What is the best strategy to follow in this case? Should you park in the first space you come to? Or should you immediately drive all the way to the theater, then turn around and take the first space you find as you head away again? But what if everyone else driving to the movies does the same thing? How should you choose a parking space in the face of everyone else’s choices so as not to have to skip buying Raisinettes before the film starts? The search for a parking space did not present much of a concern to our ancestors in the course of human evolution, but this modern trial illustrates a common aspect of the situations that challenged our evolving minds: The problem here and in many other social domains is how to make decisions in
Old Drug, New Target

Background: rRNA synthesis by Pol-I is a key and rate-limiting stage of ribosome biogenesis. Results: Ellipticines selectively inhibit Pol-I transcription both in vitro and in cells. Conclusion: Interactions of essential transcription factor SL1 with the promoter is the primary target of the drugs. Significance: This study reveals a novel class of Pol-I inhibitors and analyses their mechanism of action. Transcription by RNA polymerase I (Pol-I) is the main driving force behind ribosome biogenesis, a fundamental cellular process that requires the coordinated transcription of all three nuclear polymerases. Increased Pol-I transcription and the concurrent increase in ribosome biogenesis has been linked to the high rates of proliferation in cancers. The ellipticine family contains a number of potent anticancer therapeutic agents, some having progressed to stage I and II clinical trials; however, the mechanism by which many of the compounds work remains unclear. It has long been thought that inhibition of Top2 is the main reason behind the drugs antiproliferative effects. Here we report that a number of the ellipticines, including 9-hydroxyellipticine, are potent and specific inhibitors of Pol-I transcription, with IC50 in vitro and in cells in the nanomolar range. Essentially, the drugs did not affect Pol-II and Pol-III transcription, demonstrating a high selectivity. We have shown that Pol-I inhibition occurs by a p53-, ATM/ATR-, and Top2-independent mechanism. We discovered that the drug influences the assembly and stability of preinitiation complexes by targeting the interaction between promoter recognition factor SL1 and the rRNA promoter. Our findings will have an impact on the design and development of novel therapeutic agents specifically targeting ribosome biogenesis.
Aprendizaje automático de modelos K-explorables estocásticos en reconocimiento del habla

EL PRESENTE TRABAJO TRATA SOBRE LA OBTENCION DE MODELOS DEL LENGUAJE BAJO UNA OPTICA CONCRETA, POR UN LADO SE TRATA DE MODELOS ESTOCASTICOS, ES DECIR, QUE DETERMINAN LA PROBABILIDAD DE QUE UNA PALABRA DEL VOCABULARIO PROPIO DEL LENGUAJE OCUPE UNA POSICION DADA EN EL DISCURSO EN FUNCION DEL RESTO DEL MISMO. POR OTRO LADO, FRENTE AL ENFOQUE CONOCIDO COMO "BASADO EN EL CONOCIMIENTO" O ENFOQUE DEDUCTIVO, SE APLICA LO QUE SE CONOCE COMO "APRENDIZAJE AUTOMATICO" O ENFOQUE INDUCTIVO. DESDE LOS COMIENZOS DE LA APLICACION DE ESTE ENFOQUE SE VIENEN UTILIZANDO LO QUE SE CONOCE COMO "N-GRAMAS", SIN EMBARGO DESDE HACE ALGUN TIEMPO SE CONSIDERA QUE LA UTILIZACION DE TECNICAS DE INFERENCIA DE GRAMATICAS ESTOCASTICAS PROPORCIONA UN PLANTEAMIENTO MAS AMPLIO DEL PROBLEMA. RECIENTEMENTE SE HA DEMOSTRADO QUE LAS TECNICAS DE INFERENCIA DE GRAMATICAS PERMITEN OBTENER COMO CASO PARTICULAR MODELOS DE N-GRAMAS YA QUE ESTOS COINCIDEN CON LOS GENERADOS PARA LOS LENGUAJES CONOCIDOS COMO K-EXPLORABLES EN SENTIDO ESTRICTO (K-EE), ELEMENTO CENTRAL EN ESTE TRABAJO. LA MEMORIA COMIENZA ENMARCANDO LA MODELIZACION DEL LENGUAJE (ML) DENTRO DEL RECONOCIMIENTO AUTOMATICO DEL HABLA (RAH) PARA PASAR A CONTINUACION A HACER UNA REVISION SOBRE ML POR METODOS DE APRENDIZAJE AUTOMATICO. EN TODO MOMENTO SE EXPLICITA COMO ENCAJA LA TECNICA CLASICA DE "N-GRAMAS" EN CADA UNA DE LAS DEMAS. SITUANDOLOS EN EL LUGAR QUE LES CORRESPONDE DENTRO DE ESTA REVISION, SE FORMALIZA UN MODELO GRAMATICAL PARA LOS LENGUAJES K-EE Y SE HACE UN ESTUDIO EXPERIMENTAL SOBRE SUS CARACTERISTICAS ESTRUCTURALES. POSTERIORMENTE SE REALIZA UN ANALISIS DE LA PROBLEMATICA DE LA ESTIMACION DE PROBABILIDADES EN LOS MODELOS, ORIGINADA POR LA FINITUD DE TODO CORPUS DE MUESTRAS. SE PRESENTAN LAS SOLUCIONES QUE SE ENCUENTRAN EN LA BIBLIOGRAFIA (LOS METODOS DE SUAVIZADO) PARA PASAR A LA PRESENTACION DE UN ESTUDIO EXPERIMENTAL DE LAS CARACTERISTICAS DE LAS DISTRIBUCIONES DE PROBABILIDAD DE LOS MODELOS PARA