Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring multilingual speakers’ perspectives on their intelligibility in English

ABSTRACT Multilingual speakers’ ability to communicate effectively and intelligibly in the language of their country of residence is crucial to their participation. This study explored multilingual speakers’ motivations for improving their intelligibility in English and their perceptions of potential barriers and facilitators to enhancing intelligibility. Participants were multilingual students and staff at 14 Australian universities. Extended response data from 137 survey responses were combined with seven semi-structured interviews, thematically analyzed using the World Health Organization’s International Classification of Functioning, Disability and Health as a conceptual framework, and coded using NVivo software. Three overarching themes were: motivations, barriers, and facilitators. Themes that emerged under motivations were meeting their own and others’ expectations and career aspirations. Themes that emerged under barriers to intelligibility were lack of self-awareness of reduced English intelligibility, use of ineffective strategies (e.g., fast speech rate to disguise pronunciation difficulties), language differences, lack of opportunity to practise English, participants’ perceptions of others’ negative attitudes to their English skills, and challenging conversational partners. Facilitators to intelligibility were emotional support from others, beneficial strategies (e.g., confirming listener understanding), and opportunities to practice. The results highlight the importance of supporting multilingual speakers’ efforts to improve their English intelligibility. An environment with barriers such as lack of opportunity to practise English may restrict an individuals’ performance and participation, while facilitators such as support from others may increase participation. This study will inform the understanding of speech-language pathologists engaged in intelligibility enhancement, as well as SLPs working with multilingual speakers in any context.
Menstrual cycle and headache in a population sample of migraineurs

Background: Migraine is three times more common in women than men. There is a clinical impression that migraines are more common and severe around the time of menses. Objectives: To determine 1) the distribution of headache attacks by day of the menstrual cycle in women with migraine, 2) if the excess occurrence varies by headache type, and 3) if headache features differ by time in the menstrual cycle. Methods: In a population-based sample, 81 menstruating women with clinically diagnosed migraine were enrolled in a 98-day diary study and completed a total of 7219 diary days. The daily diary was used to record the occurrence of menses, headache days, and, on days with headache, associated headache features (i.e., symptoms, quality-of-pain, attack duration, pain intensity, and disability at work, household work, and nonwork activities). Results: An excess risk of headache occurred perimenstrually and was highest on days 0 and 1 of the cycle (day 0 being the first day of menses). A significantly elevated risk of headache on days 0 and 1 was observed for migraine without aura (OR 2.04; 95% CI 1.49, 2.81) and for tension-type headache (OR 1.67; 95% CI 1.24, 2.25). Elevated risks were also observed in the 2 days before onset of menses for migraine without aura (OR 1.80; 95% CI 1.40, 2.30). A significantly lower risk was observed around the time of ovulation for all headaches (OR 0.44; 95% CI 0.27, 0.72). Few significant differences were observed in headache features (i.e., pain intensity, disability score, symptom score, headache duration) by day of the cycle overall or by headache type. Pain intensity was slightly greater for migraine headaches during the first 2 days of menses. Conclusions: Attacks of migraine without aura, but not migraine with aura, were more likely to occur 2 days before onset of menses and on the first 2 days of menses. This study does not support the clinical notion that headaches, regardless of type, are more severe during the perimenstrual period compared to other times in the cycle. Although migraine headaches are significantly more painful during the first 2 days of menses, differences are small. –1523
Consumer‐food systems: why type I functional responses are exclusive to filter feeders

The functional response of a consumer is the relationship between its consumption rate and the abundance of its food. A functional response is said to be of type I if consumption rate increases linearly with food abundance up to a threshold level at which it remains constant. According to conventional wisdom, such type I responses are more frequent among filter feeders than among other consumers. However, the validity of this claim has never been tested. We review 814 functional responses from 235 studies, thereby showing that type I responses are not only exceptionally frequent among filter feeders but that they have only been reported from these consumers.
Antibody labeling of functional subdivisions in visual cortex: Cat-301 immunoreactivity in striate and extrastriate cortex of the macaque monkey

Abstract We have examined the distribution of immunoreactivity for the monoclonal antibody Cat-301 in visual cortex of the macaque monkey. Remarkably, those portions of striate cortex (V1) and extrastriate cortex that are most immunoreactive for Cat-301 are anatomically interconnected and are dominated by inputs arising from the magnocellular layers of the LGN (which are themselves highly immunoreactive). In particular, we found that a band of Cat-301 labeled neurons known to exist in layer 4 of V1 is centered on the boundary between layers 4Cα and 4B and thus includes portions of both the primary target of the magnocellular LGN and its subsequent relay through layer 4B. We also demonstrated consistently strong Cat-301 immunoreactivity in all three extrastriate targets of layer 4B: areas V3, MT, and the cytochrome-oxidase (CO) enriched thick stripes of V2. In V2, there was a close correlation between Cat-301 labeling and clusters of cells projecting to MT but not to V4. This was true even in regions where the CO pattern was equivocal or irregular, indicating that Cat-301 is a more reliable marker than CO for the thick-stripe subregions of V2. Finally, we found strong Cat-301 immunoreactivity in at least parts of areas V3A, the MST complex, and the posterior parietal complex, but not in area V4 or inferotemporal cortex. The molecular specificity revealed by this single marker thus correlates with functionally specific subdivisions at each hierarchical level over nearly the entire known extent of the visual pathway in macaques. This supports the notion that these subdivisions form an anatomically, physiologically, and now molecularly distinct pathway known as the M-stream.
Integration-proficient plasmids for Pseudomonas aeruginosa: site-specific integration and use for engineering of reporter and expression strains.

An improved method for integration of exogenous DNA fragments at a defined site within the genome of Pseudomonas aeruginosa was developed. The method relies on two integration-proficient vectors, mini-CTX1 and mini-CTX2. These two vectors contain (1) a tetracycline (tet) selectable marker, (2) an oriT for conjugation-mediated plasmid transfer, (3) the pMB1-derived origin of replication, (4) a modified φCTX integrase (int) gene, (5) a versatile multiple cloning site (MCS) flanked by T4 transcriptional termination sequences (Omega elements), and (6) the φCTX attachment site. The MCS and Omega elements are flanked by yeast Flp recombinase target sites that allow in vivo excision of unwanted plasmid backbone sequences, including tet and int, from the genome of integrants by Flp recombinase. In the mini-CTX2 vector int transcription is driven from the strong trc promoter, which is regulated by the Lac repressor that is encoded by lacI(q) also contained on the plasmid. Upon conjugal transfer, mini-CTX1 and mini-CTX2 integrated at frequencies of 10(-8) and 10(-7), respectively. The usefulness of the integration vectors for gene fusion analyses was demonstrated by chromosomal insertion of autoinducer (AI)-regulated lasB-lacZ and rhlA-lacZ fusions into wild-type and AI synthase mutants. In wild-type, the fusions responded in a cell density-dependent manner and expression of both fusions was either greatly reduced or abolished in AI synthase mutants. Finally, an expression cassette containing the T7 polymerase gene under Lac repressor control was constructed, integrated into the P. aeruginosa chromosome, and used to express the hexahistidine-tagged P. aeruginosa AI synthase RhlI.
A new set of chemotaxis homologues is essential for Myxococcus xanthus social motility

Myxococcus xanthus cells aggregate and develop into multicellular fruiting bodies in response to starvation. A new M. xanthus locus, designated dif for defective in fruiting, was identified by the characterization of a mutant defective in fruiting body formation. Molecular cloning, DNA sequencing and sequence analysis indicate that the dif locus encodes a new set of chemotaxis homologues of the bacterial chemotaxis proteins MCPs (methyl‐accepting chemotaxis proteins), CheW, CheY and CheA. The dif genes are distinct genetically and functionally from the previously identified M. xanthus frz chemotaxis genes, suggesting that multiple chemotaxis‐like systems are required for the developmental process of M. xanthus fruiting body formation. Genetic analysis and phenotypical characterization indicate that the M. xanthus dif locus is required for social (S) motility. This is the first report of a M. xanthus chemotaxis‐like signal transduction pathway that could regulate or co‐ordinate the movement of M. xanthus cells to bring about S motility.
Proceedings of the Joint Conference of the 47th Annual Meeting of the ACL and the 4th International Joint Conference on Natural Language Processing of the AFNLP: Volume 2 - Volume 2

Welcome to the ACL-IJCNLP 2009, the first joint conference sponsored by the ACL (Association for Computational Linguistics) and the AFNLP (Asian Federation of Natural Language Processing). The idea to have a joint conference for ACL and AFNLP was first discussed at ACL-05 (Ann Arbor, Michigan) among Martha Palmer (ACL President), Benjamin T'sou (AFNLP President), Jun'ichi Tsujii (AFNLP Vice President) and Keh-Yih Su (AFNLP Conference Coordinating Committee Chair, also the Secretary General). We are glad that the original idea has come true four years later, and even the affiliation relationship between these two organizations has been built up now. In this joint conference, we have tried to mix the spirit from both ACL and AFNLP; and, Singapore, which itself has a mixture of diversified cultures from eastern and western regions, is certainly a wonderful place to see how different languages meet each other. We hope you will enjoy this big event held in this garden city, which is brought to you via the efforts from each member of the conference organization team.
Evaluation of Diesel Exhaust Continuous Monitors in Controlled Environmental Conditions

Diesel exhaust (DE) contains a variety of toxic air pollutants, including diesel particulate matter (DPM) and gaseous contaminants (e.g., carbon monoxide (CO)). DPM is dominated by fine (PM2.5) and ultrafine particles (UFP), and can be representatively determined by its thermal-optical refractory as elemental carbon (EC) or light-absorbing characteristics as black carbon (BC). The currently accepted reference method for sampling and analysis of occupational exposure to DPM is the National Institute for Occupational Safety and Health (NIOSH) Method 5040. However, this method cannot provide in-situ short-term measurements of DPM. Thus, real-time monitors are gaining attention to better examine DE exposures in occupational settings. However, real-time monitors are subject to changing environmental conditions. Field measurements have reported interferences in optical sensors and subsequent real-time readings, under conditions of high humidity and abrupt temperature changes. To begin dealing with these issues, we completed a controlled study to evaluate five real-time monitors: Airtec real-time DPM/EC Monitor, TSI SidePak Personal Aerosol Monitor AM510 (PM2.5), TSI Condensation Particle Counter 3007, microAeth AE51 BC Aethalometer, and Langan T15n CO Measurer. Tests were conducted under different temperatures (55, 70, and 80°F), relative humidity (10, 40, and 80%), and DPM concentrations (50 and 200 μg/m3) in a controlled exposure facility. The 2-hr averaged EC measurements from the Airtec instrument showed relatively good agreement with NIOSH Method 5040 (R2 = 0.84; slope = 1.17±0.06; N = 27) and reported ∼17% higher EC concentrations than the NIOSH reference method. Temperature, relative humidity, and DPM levels did not significantly affect relative differences in 2-hr averaged EC concentrations obtained by the Airtec instrument vs. the NIOSH method (p < 0.05). Multiple linear regression analyses, based on 1-min averaged data, suggested combined effects of up to 5% from relative humidity and temperature on real-time measurements. The overall deviations of these real-time monitors from the NIOSH method results were ≤20%. However, simultaneous monitoring of temperature and relative humidity is recommended in field investigations to understand and correct for environmental impacts on real-time monitoring data.
Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells

Thymic epithelial cells (TEC) form the structural and functional microenvironment necessary for the establishment and quality control of the T cell repertoire. In addition, they provide an ectopic source of numerous tissue‐restricted antigens (TRA), a feature called promiscuous gene expression (pGE). How the regulation of pGE is related to the cell biology of TEC subset(s), e.g. their turnover and developmental interrelationship is still poorly understood. The observation that pGE is foremost a property of phenotypically and functionally mature medullary TEC (mTEC) implies that the full implementation of pGE is contingent on mTEC differentiation. Here, we show that the emergence of TEC subsets and pGE is tightly correlated during ontogeny and we provide evidence that mature CD80pos mTEC develop from an immature CD80neg subset. This differentiation step proceeds continuously in the postnatal thymus. While mature mTEC turnover in 2 to 3 weeks, immature mTEC encompass a smaller cycling and a larger non‐cycling pool. The latter might serve as a reservoir of committed precursors, which sustain this renewal process. Our data document that mTEC represent a highly dynamic cell population, and they imply that the availability and display of TRA in the thymus undergoes a perpetual temporal and spatial reorganization.
Fraternal Birth Order and Ratio of Heterosexual/Homosexual Feelings in Women and Men

Abstract Studies of the 2-3% of persons who identify as homosexual found men but not women had more older brothers than persons who identify as heterosexual. The present study investigated the birth order in the approximately 20% of men and women who anonymously report some homosexual feelings, few of whom identify as homosexual. The number of older brothers and sisters was investigated in seven cohorts: 319 male twins; and 49,54, and61 female and 66,116, and 50 male medical students. Both women and men who anonymously reported homosexual feelings had a greater mean number of older brothers and sisters than did those who reported no homosexual feelings. The difference was stronger in relation to brothers than sisters. The birth order effect was not related to the strength of the subjects' degree of homosexual compared with heterosexual feelings. Its presence in women could not be accounted for by the widely accepted hypothesis that the birth order effect is due to a maternal immune reaction provoked only by male fetuses. The lack of relationship between the strength of the effect and degree of homosexual feelings in the men and women suggests the influence of birth order on homosexual feelings was not due to a biological, but a social process in the subjects studied. Investigating the neglected significant percentage of predominantly heterosexual men and women who anonymously report some homosexual feelings may aid in understanding the factors influencing sexual orientation, and identity.
Ambient temperatures preferred by young European males and females at rest.

Forty-eight young adults (24 men and 24 women) stayed for three hours in a climatic chamber setting, lightly clothed and seated at rest with no prescribed task; rectal and mean skin temperatures were continuously recorded. During the first hour, the subjects were exposed to an imposed ambient temperature (25.1 degrees C) during which body temperatures stabilized and subjective thermal judgments were collected. For the next two hours they could freely set the ambient temperature at the level(s) they preferred. The subjects spent about one hour seeking a preferred temperature (transition period), which subsequently turned out to be unsteady in most cases. The overall mean of the individual average preferred temperatures (third hour) was 26.6 degrees C (S.D. = 2.6 degrees C). Significant time of day (morning versus afternoon) effects were found on preferred ambient and actual body temperatures. The body temperatures previously recorded at 25.1 degrees C were significantly predictive of the average ambient temperatures preferred between one and two hours later (third hour); the multiple regression equations differed markedly between men and women.
Nerve segmentation in ultrasound images

Today medical field has provided us enormous facilities that has been never thought before. There has been done many improvements in the field of surgery, medicine, X-Rays and many more. But some areas still want some improvements so that patients don't need to face any type of difficulty or pain. This paper is trying to highlight the difficulties and in the treatments that are based on the ultrasound images. So in paper this our main focus is to improve the treatments based on ultrasound scans which is used widely in medical field due to vast area of application and cost effectiveness. These ultrasound scans are very important to detect any kind of injury of disease in human body because it used to scan the internal tissues of the body. One major disadvantage of these images is that they include huge amount of noise so doctors face difficulty in finding the exact location of the nerve where they have to inject the medicine to operate. These pictures are not clear enough to find the neve at once so they have to inject needle very times. With this application they can find the nerve very easily because it includes the segmentation of these nerves in ultrasound images. This application is further extended to train the system with this data so that it can be used worldwide.
GRCA: a hybrid genetic algorithm for circuit ratio-cut partitioning

A genetic algorithm for partitioning a hypergraph into two disjoint graphs of minimum ratio cut is presented. As the Fiduccia-Mattheyses graph partitioning heuristic turns out to be not effective when used in the context of a hybrid genetic algorithm, we propose a modification of the Fiduccia-Mattheyses heuristic for more effective and faster space search by introducing a number of novel features. We also provide a preprocessing heuristic for genetic encoding designed solely for hypergraphs which helps genetic algorithms exploit clustering information of input graphs. Supporting combinatorial arguments for the new preprocessing heuristic are also provided. Experimental results on industrial benchmarks circuits showed visible improvement over recently published algorithms with a lower growth rate of running time.
Shipping of therapeutic somatic cell products.

BACKGROUND AIMS Shipment of therapeutic somatic cells between a current good manufacturing practice (cGMP) facility and a clinic or between different cGMP facilities requires validated standard operating procedures (SOP). Under National Heart Lung & Blood Institute (NHLBI) sponsorship, the Production Assistance for Cellular Therapies (PACT) group conducted a validation study for the shipping SOP it has created, including shipments of cryopreserved somatic cells, fresh peripheral blood specimens and apheresis products. METHODS Comparisons of pre- and post-shipped cells and cell products at the three participating facilities included measurements of viability, phenotypic profiles and cellular functions. The data were analyzed at the University of Pittsburgh Biostatistics Facility. RESULTS No consistent shipping effects on cell viability, phenotype or functions were detected for cryopreserved and shipped peripheral blood mononuclear cells (PBMC), monocytes, immature dendritic cells (iDC), NK-92 or cytotoxic T cells (CTL). Cryopreserved mesenchymal stromal cells (MSC) had a significantly decreased viability after shipment, but this effect was in part because of inter-laboratory variability in the viable cell counts. Shipments of fresh peripheral blood and apheresis products for the generation of CTL and dendritic cells (DC), respectively, had no significant effects on cell product quality. MSC were successfully generated from fresh bone marrow samples shipped overnight. CONCLUSIONS This validation study provides a useful set of data for guiding shipments of therapeutic somatic cells in multi-institutional clinical trials.
Risk Analysis for Invasive Species: General Framework and Research Needs

A joint workshop was convened by the Society for Risk Analysis Ecological Risk Assessment Specialty Group and the Ecological Society of America Theoretical Ecology Section to provide independent scientific input into the formulation of methods and processes for risk assessment of invasive species. In breakout sessions on (1) the effects of invasive species on human health, (2) effects on plants and animals, (3) risk analysis issues and research needs related to entry and establishment of invasive species, and (4) risk analysis issues and research needs related to the spread and impacts of invasive species, workshop participants discussed an overall approach to risk assessment for invasive species. Workshop participants agreed on the need for empirical research on areas in which data are lacking, including potential invasive species, native species and habitats that may be impacted by invasive species, important biological processes and phenomena such as dispersal, and pathways of entry and spread for invasive species. Participants agreed that theoretical ecology can inform the process of risk assessment for invasive species by providing guidelines and conceptual models, and can contribute to improved decision making by providing a firm biological basis for risk assessments.
Understanding the determinants of social innovation in Europe: an econometric approach

ABSTRACT The objective of the paper is to understand the various determinants of social innovation incidence at the macroeconomic level across countries in Europe. Using a multivariate regression framework, the paper analyses the role of various characteristics from the ecosystem in which social innovations occur. In particular, the paper quantifies the relative importance of several factors, such as educational attainment, ease of doing business index, corruption index, risk preferences, cultural and social norms, to name a few. Methodologically, the paper takes into account the evolution of macroeconomic circumstances, such as the economic crisis of 2008 or general time trend, by collecting a panel data of various indicators from different data sources across countries and over time. As part of robustness checks, the paper uses three different measures of social innovation and includes country fixed effects to account for heterogeneities across countries.