Miracle-dz/UniFAR-FTUs huggingface dataset:
[Treating Cancer-related Fatigue after Chemotherapy in Lung Cancer Patients by Yiqi Jianpi Recipe: a Clinical Study].

OBJECTIVE To evaluate the clinical efficacy of Yiqi Jianpi Recipe (YJR) in treating cancer-related fatigue (CRF) after chemotherapy in lung cancer patients. Methods Totally 124 lung cancer patients were assigned to the treatment group (63 cases) and the control group (61 cases) according to random digit table. All patients received pre-set chemotherapy regimens according their conditions. Patients in the treatment group took YJR Decoction from the 1st day of chemotherapy, one dose per day for 2 successive weeks, while those in the control group took no Chinese medical decoction. Changes of each dimensional scoring and the total scoring were observed by cancer fatigue scale (CFS) in the two groups one day before chemotherapy, on the 3rd day and the 14th day after chemotherapy. The degree of bone marrow depression and recombinant human granulocyte colony-stimulating factor (rhG-CFS) doses were also observed after chemotherapy. RESULTS Compared with one day before chemotherapy in the same group, scorings for emotional, perceptional, and somatologic dimensions, and the total scoring significantly increased on the 3rd day in the treatment group, as well as on the 3rd and the 14th day in the control group (P <0. 01). Scorings for emotional, perceptional, and somatologic dimensions, and the total scoring significantly decreased more at the fourteenth day after chemotherapy than at the 3rd day after chemotherapy (P <0. 01). There was statistical difference in the scoring for perceptional dimension at day 3 between the treatment group and the control group (P <0.01). However, scorings for emotional, perceptional, and somatologic dimensions, and the total scoring significantly decreased more at the fourteenth day after chemotherapy in the treatment group, with statistical difference when compared with those in the control group (P <0. 01). The occurrence rate of bone marrow depression was 70. 97% (44/62) in the treatment group and 68. 85% (42/61) in the control group. There was no significant difference in the occurrence rate between the two groups (χ2=0. 540, P >0.05). There was no statistical difference in rhG-CFS doses between the two groups (χ2=0. 696, P >0. 05). CONCLUSION YJD could significantly relieve CRF after chemotherapy in lung cancer patients, and obviously attenuate the effect of CRF on their daily life.
Cortical thickness analysis in temporal lobe epilepsy

Objective: To assess the reproducibility of neocortical atrophy and its clinical significance across the spectrum of temporal lobe epilepsy (TLE), in particular with respect to postsurgical outcome. Methods: MRI-based cortical thickness measurement was obtained in 105 patients. A total of 58 had hippocampal atrophy on magnetic resonance volumetry (TLE-HA) and 47 had normal hippocampal volumes (TLE-NV). Twenty-seven patients had repeated scans with a mean interval of 28 months. Patients were compared to 48 age- and sex-matched healthy controls. We used linear models to assess cortical thinning and the effect of seizure control after surgery. Reproducibility of finding cortical atrophy was statistically evaluated using bootstrap simulations. Results: Cross-sectional and longitudinal analyses revealed highly similar topology and rates of neocortical thinning in both TLE groups, predominantly in frontocentral, temporal, and cingulate regions. Bootstrap methods showed that at least 20 subjects per group were necessary to reliably observe these patterns of atrophy in TLE. Moreover, power analysis showed that even with sample sizes of 80 subjects per group, differences in thickness between TLE-HA and TLE-NV would be marginal. With respect to postsurgical outcome, we found an association between residual seizures and atrophy in temporopolar and insular cortices in TLE-HA, and in the posterior quadrant in TLE-NV. Conclusion: We demonstrated with a high degree of confidence that static and dynamic effects of epilepsy impact similarly the neocortex of patients with hippocampal atrophy and patients with normal hippocampal volumes. On the contrary, areas predicting unfavorable postsurgical outcome were distinct, suggesting different configurations of epileptogenic networks in these 2 groups.
The New State of the Art: Cas9 for Gene Activation and Repression

ABSTRACT CRISPR-Cas9 technology has rapidly changed the landscape for how biologists and bioengineers study and manipulate the genome. Derived from the bacterial adaptive immune system, CRISPR-Cas9 has been coopted and repurposed for a variety of new functions, including the activation or repression of gene expression (termed CRISPRa or CRISPRi, respectively). This represents an exciting alternative to previously used repression or activation technologies such as RNA interference (RNAi) or the use of gene overexpression vectors. We have only just begun exploring the possibilities that CRISPR technology offers for gene regulation and the control of cell identity and behavior. In this review, we describe the recent advances of CRISPR-Cas9 technology for gene regulation and outline advantages and disadvantages of CRISPRa and CRISPRi (CRISPRa/i) relative to alternative technologies.
Determinants in the envelope E protein and viral RNA helicase NS3 that influence the induction of apoptosis in response to infection with dengue type 1 virus.

One mechanism by which dengue (DEN) virus may cause cell death is apoptosis. In this study, we investigated whether the genetic determinants responsible for acquisition by DEN type 1 (DEN-1) virus of mouse neurovirulence interfere with the induction of apoptosis. Neurovirulent variant FGA/NA d1d was generated during the adaptation of the human isolate of DEN-1 virus strain FGA/89 to grow in newborn mouse brains and mosquito cells in vitro [Desprès, P. Frenkiel, M. -P. Ceccaldi, P.-E. Duarte Dos Santos, C. and Deubel, V. (1998) J. Virol. , 72: 823-829]. Genetic determinants possibly responsible for mouse neurovirulence were studied by sequencing the entire genomes of both DEN-1 viruses. Three amino acid differences in the envelope E protein and one in the nonstructural NS3 protein were found. The cytotoxicity of the mouse-neurovirulent DEN-1 variant was studied in different target cells in vitro and compared with the parental strain. FGA/NA d1d was more pathogenic for mouse neuroblastoma cells and attenuated for human hepatoma cells. Changes in virus replicative functions and virus assembly may account, in a large part, for the differences in the induction of apoptosis. Our data suggest that identified amino acid substitutions in the envelope E protein and viral RNA helicase NS3 may influence DEN-1 virus pathogenicity by altering viral growth.
Thematic role assignment in context

Abstract Two experiments are described in which participants read sentences of the form “He drank some …” in contexts which either did or did not introduce something drinkable. Participants were more likely to report that the sentence stopped making sense at the verb “drank” if nothing drinkable had been introduced. When participants responded, in this case, that the verb did make sense, their reaction times tended to be elevated relative to when the context did introduce a suitable antecedent. The experiments were modeled on a series of studies reported by Boland, Tanenhaus, Garnsey, and Could not link Carlson (1995), who used the same stop-making-sense judgment task to investigate the processing of filler-gap dependencies of the form “I wondered which food the man drank … . ” They observed increased “no” responses on the verb when the prior filler was an implausible recipient of the patient role associated with the verb and concluded that the wh-phrase is assigned a thematic role as soon as the verb “drank” is encountered. In the studies reported here, with materials which did not contain obligatory syntactic (filler-gap) dependencies, the equivalent phenomenon was observed—thematic information conveyed by a verb's lexical entry was apparently evaluated, at the verb, with respect to its fit with whatever contextually introduced entities were available to receive the associated role. The data suggest that thematic roles may be assigned at a verb on the basis of thematic fit with context.
Development of 5-Axis Friction Stir Welding System

A friction stir welding system with the flexibility of five axes has developed to join 3-dimensional curved surface. The features of the hardware of this system are: (1) the tool pressurization by an air cylinder is adopted. (2) In order to use for various researches, it has two kinds of FSW tool heads. (3) A 3-dimensional coordinate measuring instrument is installed to teach the weld line. The features of the software for this system are: (a) weld line is taught after a work piece is set on the table, (b) the control program is described by NC language, (c) the edition of welding conditions and the simulation of the tool path are available. This paper reports the structure and features of the system, and examples of FSW by the system
On-line adaptive control for minimizing slippage error while mobile platform and manipulator operate simultaneously for robotics mobile manipulation

Mecanum wheels can apply a flexible mobility to a mobile robot, in this paper, a mobile manipulation robot is designed with combination of a Mecanum wheeled mobile platform and a 7-degrees of freedom (DoF) robot manipulator. Due to the mechanism of Omni-directional mobility, the Mecanum wheeled robot suffers with slip errors on the free rollers, these errors may be reduced with additional sensors and appropriate feedback control. However, while the mobile platform and the manipulator operate simultaneously, the displacement of the center of gravity of the whole robot increases the complexity to the motion control. To solve this problem, we analyze and model the effect of inconsistency of slippage errors caused by the unbalance of normal force on the wheels, and propose an on-line adaption slippage model for the Mecanum vehicle to generate a better control system to reduce these errors. We proof the effectiveness by using our proposed adaption model and on-line compensation control with experiments.
An Evaluation of Publication Productivity in Information Systems: 1999 to 2003

University hiring, promotion and tenure decisions make researchers’ publication productivity an important issue. This study reports on data about publication productivity of information systems (IS) researchers from 1999 to 2003. We collected information about IS papers published in twelve IS journals during this period. After classification, the most productive individuals and institutions for this sample are identified. We also compared our findings with past research to demonstrate the changes in publication productivity over time. Publication productivity changes somewhat among researchers and institutions.
A FACE OCULTA DO RACISMO NO BRASIL

As vezes penso: como e dificil discutir sobre o tema racismo no Brasil, no entanto as pessoas sempre tem sempre uma historia de indignacao para contar sobre o racismo, mas afinal como se da o racismo no Brasil? Por certo que o nosso pais se estruturou e construiu ao longo de sua historia uma forma de racismo que se esconde, que todo mundo sabe que existe, mas dificil de provar, de punir esse crime e isso por conta da forma de como ele espalhado no seio social, dessa, podemos dizer que e oculto aos nossos olhos, mas e o principal entrave no desenvolvimento economico do negro no Brasil. Pois esse racismo faz do negro um marginal, porque nao nos damos conta que a marginalidade e a maldade, nao tem cor nao tem credo, nem nivel social, mas para a nossa sociedade que esta acostumada a vincular o negro a servicos inferiores e a criminalidade, nao resta duvidas, que ai nesse ponto comeca a desigualdade.
Asthma and Rhinitis after Exposure to Glutaraldehyde in Endoscopy Units

1 Four nurses working in endoscopy units complained of respiratory symptoms on exposure to alkaline glutaraldehyde used as a disinfectant for fibre-optic endoscopes. 2 A provocation test was positive in two of these patients. 3 This is the first report to use provocation testing to confirm a relation between exposure to alkaline glutaraldehyde and respiratory disease.
Ziele und Handlungen von Lehrkräften – Eine Untersuchung zu Lehrerzielen, ihrer Struktur und den Zusammenhängen zu subjektivem Wohlbefinden, Unterrichtsqualität und der wahrgenommenen Wirksamkeit von Unterrichtsmethoden

Lehrkrafte verfolgen in ihrem Beruf eine Vielzahl inhaltlich unterscheidbarer Ziele, wobei bislang nur sehr wenige Arbeiten vorliegen, die diese systematisch erfassen und klassifizieren. Um das Zielstreben der Lehrkrafte differenziert zu messen und daruber hinaus zu uberprufen, wie unterschiedliche inhaltliche Zielauspragungen mit dem Erleben und Verhalten der Lehrkrafte in Zusammenhang stehen, wurden drei empirische Studien durchgefuhrt. Die erste Studie verdeutlicht die Entwicklung eines quantitativen Messinstruments, das es in Anlehnung an die qualitative Arbeit von Hagger und Malmberg (2011) erlaubt, insgesamt 13 verschiedene Ziel-Inhaltskategorien mit jeweils vier Items zu erfassen. Die Testung an 132 Lehramtsstudierenden sowie 227 im Beruf stehenden Lehrkraften zeigt erste Evidenzen fur die psychometrische Qualitat dieses Instruments. Es lassen sich drei Faktoren hoherer Ordnung finden, die als sozio-emotionaler, aufgabenbezogener und selbstbezogener Faktor interpretiert werden konnen. Ferner zeigen sich positive Korrelationen zur Lehrerselbstwirksamkeit, dem Selbstwert und Lebenszufriedenheit, negative zur emotionalen Erschopfung. Die zweite empirische Arbeit verdeutlicht in Form einer Beobachtungsstudie an 34 Unterrichtsklassen die besondere Bedeutung der Ziele fur das Verhalten der Lehrkrafte. So lasst sich feststellen, dass insbesondere die von Lehrkraften berichteten sozio-emotionalen Ziele signifikant mit den fremdeingeschatzten Unterrichtsqualitatsmerkmalen der Klassenfuhrung und des lernforderlichen Klimas im positiven Zusammenhang stehen. In der dritten Studie mit 188 Lehramtsstudierenden, 85 Referendaren sowie 117 Lehrkraften lasst sich nachweisen, dass die Ziele auch mit den Einschatzungen uber die Wirksamkeit verschiedener Unterrichtsmethoden in Zusammenhang stehen. So zeigt sich mittels eines clusteranalytischen Vorgehens, dass vor allem diejenigen Cluster der Lehrkrafte, die durch ein Muster von stark ausgepragten sozio-emotionalen Zielen charakterisiert sind, zu einer ausgepragt positiven Wirksamkeitseinschatzung schulergeleiteter Unterrichtsmethoden wie entdeckendem oder kooperativem Lernen tendieren, und vor allem diejenigen Cluster der Lehrkrafte, die durch ein Muster von stark ausgepragten aufgabenbezogenen Zielen charakterisiert sind, zu einer positiven Wirksamkeitseinschatzung lehrergeleiteter Unterrichtsmethoden wie regelmasigen Hausaufgaben oder der direktiven Instruktion tendieren. Die Ergebnisse werden sowohl hinsichtlich der Moglichkeiten und Limitationen der Fragebogenentwicklung sowie der Bedeutung der Ziele fur das Erleben und das Unterrichtsverhalten kritisch diskutiert.
Cryptanalysis of a robust key agreement based on public key authentication

This paper considers security analysis of the YAK, a public key-based authenticated key agreement protocol. The YAK protocol is a variant of the two-pass HMQV protocol but uses zero-knowledge proofs for proving knowledge of ephemeral values. In this paper, we show that the YAK protocol lacks joint key control and perfect forward secrecy attributes and is vulnerable to some attacks including unknown key-share and key-replication attacks. This invalidates the semantic security of the protocol in several security models. There are also other considerations regarding the impersonation and small subgroup attacks. Copyright © 2015 John Wiley & Sons, Ltd.
Multiple occurrence of carcinoma in the upper aerodigestive tract associated with esophageal cancer: Reference to smoking, drinking and family history

Smoking and drinking habits as well as family history were examined in 143 men with esophageal cancer, including 30 who had associated second cancers of the upper aerodigestive tract (UADT) and 113 who did not. The risk of second cancers of UADT associated with the main lesions of the esophagus was evaluated, using odds ratios (ORs). As a result, the ORs of second cancers for current smoking and drinking were 5.3 and 7.6 respectively. The ORs significantly increased to 12.7 and 14.7 in heavy smokers and in heavy drinkers respectively. Furthermore, the risk of second cancer also significantly increased (8‐fold) in patients who had close relatives with UADT cancer, compared to those without family history of any cancer. However, there were no differences in smoking or drinking habits regardless of family history. Our data thus suggest that a family history of UADT cancer as well as heavy smoking and drinking are clearly associated with multiple occurrence of UADT cancer. Therefore, careful and frequent examination for appearance of any second lesions are required for patients in these high‐risk groups.
A Novel P2P Service Discovery Algorithm Based on Markov in Internet of Things

In order to adapt to the characteristics of high mobility, low density in Internet of Things, this paper proposes a novel P2P service discovery algorithm based on Markov. The Markov is used to achieve the prediction of the meeting time interval between any two nodes, and to construct a two-stage prediction model of meeting time interval. This paper uses the model to improve the Spay and Wait routing protocol to improve the delivery success rate of service message. The experiments show that the algorithm can improve both of the recall rate and precision without sacrificing too much time.
Cross-modal transfer with neural word vectors for image feature learning

Neural word vector (NWV) such as word2vec is a powerful text representation tool that can encode extensive semantic information into compact vectors. This ability poses an interesting question in relation to image processing research - Can we learn better semantic image features from NWVs? We empirically explore this question in the context of semantic content-based image retrieval (CBIR). In this paper, we consider cross-modal transfer learning (CMT) to improve initial convolutional neural network (CNN) image features by using NWVs. We first show that NWVs can improve semantic CBIR performance compared to classical word vectors, even if it is with simple CMT models, i.e., canonical correlation analysis (CCA). Next, inspired by a characteristic property of NWVs, we propose a new CMT model and demonstrate that it can improve CBIR performance even further.
A modified FDK with misaligned parameters of flat-panel detector in Cone-Beam CT

FDK reconstruction algorithm is the most widely used for Cone Beam CT imaging system due to its simplicity and fast implementation. However, if misalignments exist in the detector, the original FDK reconstruction algorithm will result in deteriorated reconstruction quality because of the wrong correspondence of the voxels from the object and the pixels from the projection. One way is to apply rotation-based interpolation for each projection, which not only will cause blurring of the details due to the effect of interpolation but also is very time-consuming. In back-projection based reconstruction, the key factor is to correctly relate the voxels from the object and the pixels from the projections. Based on this point of view, we propose a method that will correctly find the correspondence of the voxels and pixels. With this method, reconstruction result can be obtained with good accuracy if all the misaligned parameters of the detector are known. And also, detail information can be better preserved compared with the rotation-based interpolation method. In the validation period, a simulation program of Cone-Beam CT was developed. In this program, all misaligned parameters of detector are able to be set. And the simulated result proves that our method is efficient and feasible although it suffers a little deterioration, and can further be used in online calibration of CBCT.
A New Approach to Business Processes

This paper presents a methodology for analyzing and designing the processes that an enterprise uses to conduct its business. The methodology builds upon traditional approaches to business process definition by adding the dimension of people's accountabilities: their roles, relationships, and agreements. The approach presented allows for unique insights into customer satisfaction, employee empowerment, and quality. It also provides a basis for spanning the concerns of both business people and information technologists responsible for providing business process automation.
Media Animasi Menggunakan Macromedia Flash Berbasis Pemahaman Konsep Pokok Bahasan Persegi dan Persegi Panjang

This study aims to develop animation media using Macromedia flash based on the conceptual understanding of the subject of rectangle and rectangle. The research and development method used is 4D model proposed by Thiagarajan consisting of 4 stages, namely: (1) define; (2) design; (3) develop and (4) disseminate. Researchers use data collection techniques is a questionnaire in the form of Likert scale for the response of learners. The result of the research is the animation media using Macromedia flash based on the concept of the subject of rectangular and rectangle that is suitable for learning media. The feasibility of learning media obtained from the validation of material experts with an average score of 3.40 is categorized valid and validation of media experts with an average score of 3.32 are categorized as valid. Student response to learning media obtained in small group test is very interesting with an average score of 3.64. In the large group, test obtained criteria attractiveness is very interesting with an average score of 3.47.
Proteomic and immunologic analyses of brain tumor exosomes

Brain tumors are horrific diseases with almost universally fatal outcomes; new therapeutics are desperately needed and will come from improved understandings of glioma biology. Exosomes are endo‐ somally derived 30‐100 nm membranous vesicles released from many cell types into the extracellular milieu; surprisingly’ exosomes are virtually unstudied in neuro‐oncology. These microvesicles were used as vaccines in other tumor settings’ but their immunological significance is unevaluated in brain tumors. Our purpose here is to report the initial biochemical’ proteomic’ and immunological studies on murine brain tumor exosomes’ following known procedures to isolate exosomes. Our findings show that these vesicles have biophysical characteristics and proteomic profiles similar to exosomes from other cell types but that brain tumor exosomes have unique features (e.g.’ very basic isoelectric points’ expressing the mutated tumor antigen EGFRVIII and the putatively immunosuppressive cytokine TGF‐β). Administration of such exosomes into syngeneic animals produced both humoral and cellular immune responses in immunized hosts capable of rejecting subsequent tumor challenges but failed to prolong survival in established orthotopic models. Control animals received saline or cell lysate vaccines and showed no antitumor responses. Exosomes and microvesicles isolated from sera of patients with brain tumors also possess EGFR’ EGFRVIII’ and TGF‐β. We conclude that exosomes released from brain tumor cells are biochemically/biophysically like other exosomes and have immune‐modulating properties. They can escape the blood‐brain barrier’ with potential systemic and distal signaling and immune consequences. — Graner M. W. Alzate’ O. Dechkovskaia A. M. Keene J. D. Sampson J. H. Mitchell D. A. Bigner D. D. Proteomic and immunologic analyses of brain tumor exosomes. FASEBJ. 23 1541–1557 (2009)