Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring Trading Strategies and their Effects in the FX Market

One of the most critical issues that developers face in developing automatic systems or software agents for electronic markers is that of endowing the agents with appropriate trading strategies. In this paper, we examine the problem in the Foreign Exchange (FX) market and we use an agent-based FX market simulation to examine which trading strategies lead to market states in which the stylized facts (statistical properties) of the simulation match the stylised facts of the actual FX market transactions data. In particular, our goal is to explore the emergence of the stylized facts of the transactions data, when the simulated market is populated with agents using three different strategies: a variation of the zero-intelligence with a constraint (ZI-CV) strategy; the zero-intelligence directional-change event (ZI-DCT0) strategy; and a genetic programmingbased (GP) strategy. A series of experiments were conducted in an existing agent-based FX market with these three strategies and the results were compared against those of a high-frequency transactions dataset from the FX market. Our results show that the ZI-DCT0 agents best reproduce and explain the properties and phenomena observed in the FX market real transactions data. Our study suggests that the observed stylized facts of the FX market transactions data could be the result of introducing a threshold which triggers the agents to respond to fixed periodic patterns in the price time series. The results of this study can be used further to develop decision support systems and autonomous trading agent strategies for the FX market.
Vemurafenib: an evidence-based review of its clinical utility in the treatment of metastatic melanoma

The discovery of BRAF mutations in the majority of patients with metastatic melanoma combined with the identification of highly selective BRAF inhibitors have revolutionized the treatment of patients with metastatic melanoma. The first highly specific BRAF inhibitor, vemurafenib, began clinical testing in 2008 and moved towards a rapid approval in 2011. Vemurafenib induced responses in ~50% of patients with metastatic BRAF-mutant melanoma and demonstrated improved overall survival in a randomized Phase III trial. Furthermore, vemurafenib is well-tolerated with a low toxicity profile and rapid onset of action. Finally, vemurafenib is active even in patients with widely metastatic disease. Despite the success of vemurafenib in treating patients with BRAF-mutant metastatic melanoma, most, if not all, patients ultimately develop resistance resulting in disease progression at a median time of ~6 months. Multiple mechanisms of resistance have been described and rationale strategies are underway to combat resistance. This review highlights the development, clinical utility, resistance mechanisms, and future use of vemurafenib both in melanoma and other malignancies. We consulted PubMed, Scopus, MEDLINE, ASCO annual symposium abstracts, and http://clinicaltrials.gov/ for the purpose of this review.
Vector Systems Allowing Efficient Autonomous or Integrative Gene Cloning in Micromonospora sp. Strain 40027

ABSTRACT Vector systems allowing autonomous or site-specific integrative gene cloning were developed for Micromonospora sp. strain 40027, a producer of the antibiotic fortimicin A. The autonomous system depends on the discovery of a low-copy-number, self-transmissible covalently closed circular plasmid, pJTU112 (ca. 14.1 kb), which was shown to be present in the progenitor strain in both integrated and autonomous states. The copy numbers of both wild-type pJTU112 and three derivatives of it can be amplified at least sixfold by addition of streptomycin to the culture medium. The integrative system was developed by the use of a pBR322-derived Escherichia coli plasmid vector, pSET152, mediated by the attP site of the Streptomyces phage ΦC31. Both vectors can be transferred by conjugation from E. coli into Micromonospora sp. strain 40027. The heterologous cloning and expression of the dnd gene cluster originating from Streptomyces lividans 1326 into Micromonospora sp. strain 40027 demonstrated the use of the two systems.
A coding scheme is defined by a sequence of encoding functions

We consider a binary symmetric channel with additive binary interference known to the transmitter but unknown to the receiver. Depending on whether the interference signal is known noncausally or causally, this channel falls in the cases studied by Gel’fand and Pinsker and by Shannon, respectively, for which coding theorems and single-letter capacity expressions are known. In this work we present effective code constructions for both problems. In particular, we show that the non-causal interference knowledge case can be turned into an equivalent binary multipleaccess channel, for which standard superposition coding and successive decoding can be used. We discuss also two alternatives for the causal interference knowledge case, one based on time-sharing and the other based on coding over a ternary alphabet with non-uniform probability assignment.
On-chip intra decoupling measurements for integrated magnetic thin film

Performance of magnetic thin-film is evaluated as a candidate for on-chip noise suppressor. Miniature loops coils implemented on a 90 nm design test element group (TEG) chip are used as the noise transmitter and receiver. Differential transmission parameter Sdd21 is evaluated as a measure of inductive noise intra-decoupling. Magnetic film is useful for frequency selective noise decoupler. The coupling is supported most at the ferromagnetic resonance (FMR) frequency, which is deviated from its intrinsic frequency and the degree of deviation can be calculated by using characteristic length. These results demonstrate that the proposed method is useful to characterize the IC chip level noise suppressor in the GHz range.
Magnetic Field Solution in Doubly Slotted Airgap of Conventional and Alternate Field-Excited Switched-Flux Topologies

A general solution of the magnetic field in the airgap of conventional and alternate field-excited switched-flux (FE-SF) machines is proposed in this paper. The analytical model is based on the subdomain method. It involves the solution of governing field equations in a doubly slotted airgap using the variable separation method. The complete model is derived and described in a general manner so that it can be easily extended to unconventional FE-SF topologies. By means of example, analytical predictions of airgap field are extensively compared and validated using 2D FE results. FE simulations were performed on a 24-10 classical FE-SF structure and also on a novel 18-11 FE-SF machine with additional spacer teeth.
Programming by Demonstration in DLProlog

Traditionally computer programming has been conducted as a long lasting cycle of coding, testing and debugging. In comparison, in programming by demonstration (PBD), a system automatically attempts to construct a program that produces the same input-output pairs given as examples by a demonstrator. Unfortunately, in most PBD systems this automatic program construction process has been approached by nding the proper composition of simpler functions searched from a basic set. The exponential computational costs of such searches makes this approach impractical except for a few domains (i.e. text processing) in which some demonstrator's clues can be used to dramatically reduce the search space. In this work, some of the features of a PBD system under construction are presented that does not rely on function composition but in the step by step construction of a program automaton. The automaton is described in DLProlog, a dynamic logic modal extension of pure Prolog. DLProlog allows to represent the automaton states as user dened
Analysis of different speech performance in patients with multi-channel cochlear implants

The invention relates to novel 2-nitro-4- or -5-pyridyloxyphenylphosphonic acid derivatives of the formula wherein X is halogen or trifluoromethyl, Y is hydrogen or halogen, one of the two substituents A and E is a phosphonate group wherein R is C1-C4 alkyl or hydrogen, and the other is a nitro group, including the metal salts thereof and the salts thereof with ammonium and organic nitrogen bases, and to the preparation and use thereof. These compounds may be used for controlling weeds, regulating plant growth, or as microbicides.
Regular self-examination or clinical examination for early detection of breast cancer.

BACKGROUND Breast self-examination and clinical breast examination have been promoted for many years as general screening methods to diagnose breast cancer at an earlier stage in order to decrease morbidity and or mortality. The possible benefits and harms remain unclear. OBJECTIVES To determine whether screening for breast cancer by regular self-examination or clinical breast examination reduces breast cancer mortality and morbidity. SEARCH STRATEGY The Cochrane Library and Medline were searched for randomised trials; date of last search October 2002. The specialised register maintained by the Cochrane Breast Cancer Group was searched. SELECTION CRITERIA Randomised clinical trials, including cluster randomised trials. DATA COLLECTION AND ANALYSIS Decisions on which trials to include were taken independently by the reviewers based on the methods of trial. Disagreements were resolved by discussion. Intention to treat analyses were conducted using a fixed effect model with 95% confidence intervals. MAIN RESULTS Two large population-based studies (388,535 women) from Russia and Shanghai that compared breast self-examination with no intervention were included. There was no statistically significant difference in breast cancer mortality, relative risk 1.05 (95% confidence interval (CI) 0.90 to 1.24) (587 deaths in total). In Russia, more cancers were found in the breast self-examination group than in the control group (relative risk 1.24, 95% CI 1.09 to 1.41), while this was not the case in Shanghai (relative risk 0.97, 95% CI 0.88 to 1.06). Almost twice as many biopsies (3406) with benign results were performed in the screening group compared to the control group (1856), relative risk 1.89, 95% CI 1.79 to 2.00. REVIEWER'S CONCLUSIONS Data from two large trials do not suggest a beneficial effect of screening by breast self-examination whereas there is evidence for harms. There were no randomised trials of clinical breast examination. At present, breast self-examination cannot be recommended.
Mitochondrial Dna Sequence Phylogeny of 4 Populations of the Widely Distributed Cynomolgus Macaque (macaca Fascicularis Fascicularis) Materials and Methods Polymerase Chain Reaction and Sequencing

We studied the mitochondrial DNA (mtDNA) polymorphism of 304 Macaca fascicularis fascicularis (M. f. fascicularis) individuals, representative of 4 cynomolgus macaque populations (Indochina, Indonesia, Philippines, and Mauritius). By sequencing a 590-bp fragment in the hypervariable II region of the D-loop region, we defined 70 haplotypes. The homologous region was also characterized in 22 Chinese Macaca mulatta and 2 Macaca sylvanus. The phylogenetic analysis confirms the monophyly of M. f. fascicularis and defines 2 haplotype groups inside the M. f. fascicularis clade: one ''insular,'' encompassing 6 Philippines, 2 Mauritius, and 31 Indonesian haplotypes, the other ''continental'' that contains all Indochinese and 6 Indonesian haplotypes. Continental and insular group divergence time was estimated to be approximately 10 6 years before present (BP). Among Indonesian haplotypes, some have a continental origin. This suggests either direct migration from mainland to Indonesia or that remnant lineages from an ancient population genetically close to the mainland (i.e., in the Sunda Shelf, ,550 000 years BP) were subsequently brought southward to Indonesia. The low nucleotide diversity in the Philippines population suggests a bottleneck following colonization by Indonesian individuals, around 110 000 years BP. mtDNA and further observations of nuclear genetic data corroborate the mixed origin (Indonesian/continental) hypothesis of Mauritius individuals and a population bottleneck. Cynomolgus macaque (Macaca fascicularis) is used as a non-human primate model for biomedical research in various domains such as tissue allograft rejection in case of kidney (Borie et al. 2002; Wieczorek et al. 2006) or cardiac (Schroder et al. 2007) transplantation, bone marrow graft (Lau et al. 2004), immune response against pathogens (Sato et al. 2008) or new vaccines (Kita et al. 2005), and infectious diseases and particularly Simian Immunodeficiency Virus (SIV)-induced AIDS or emergent pathogens (Kuiken et al. 2003; Reed et al. 2005; Lawler et al. 2006). In all these models, the genetic background of the animals could be of great importance; in some cases, it was reported that animal geographical origin can influence the response to drugs or the sensibility to the experimental disease (Schmidt et al. 1977; Menninger et al. 2002). Numerous reports have been published on the geographical variations of the cynomolgus macaque. Tosi and Coke 2007) were studied. The phylogenetic relationships among the populations of M. fascicularis have been discussed, and discrepancies in population divergence times between mtDNA and nuclear markers have been found. Moreover, the analysis of paleoclimate in South Asia has led some authors to propose …
BUILDING MODELING FROM LIDAR AND AERIAL IMAGERY

This paper presents a modeling system using airborne LiDAR and aerial imagery. Our approach is a hierarchical technique that allows users to create a hierarchical building model composed of geometric primitives. Linear primitives and high-order surface primitives are used for model fitting and refinement. To improve accuracy and efficiency, we use image information to aid model and refine processes. Both the knowledge-level and pixel-level information are used. The texture and color information from aerial image is used to automate the segmentation process. Building shape cues from range image are used to reduce the number of model hypotheses and computation complexity. Edges from high resolution aerial images are used to improve the model accuracy. We demonstrated the system’s flexibility and capability for modeling wide range of complex buildings.
Limited Observations and Local Information in Convention Emergence

In multi-agent systems it is often desirable for agents to adhere to standards of behaviour that minimise clashes and wasting of (limited) resources. In situations where it is not possible or desirable to dictate these standards globally or via centralised control, convention emergence offers a lightweight and rapid alternative. Placing fixed strategy agents within a population has been shown to facilitate faster convention emergence with some degree of control. Placing these fixed strategy agents at topologically influential locations (such as high-degree nodes) increases their effectiveness. However, finding such influential locations often assumes that the whole network is visible or that it is feasible to inspect the whole network in a computationally practical time, a fact not guaranteed in many real-world scenarios. We present an algorithm, PO-Place, that finds influential nodes given a finite number of network observations. We show that PO-Place finds sets of nodes with similar reach and influence to the set of high-degree nodes and we then compare the performance of PO-Place to degree placement for convention emergence in several real-world topologies.
Clonidine Suppresses 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine‐Induced Reductions of Striatal Dopamine and Tyrosine Hydroxylase Activity in Mice

Abstract: Recent findings have shown that excitatory amino acid may be involved in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) toxicity. At the same time, evidence is accumulating that the endogenous nor‐adrenergic system plays a protective role in MPTP‐induced striatal dopamine (DA) depletion and nigral dopaminergic cell death. Recently, α2‐adrenoceptors located on glutamatergic axons have been shown to inhibit glutamate overflow. In this study, we evaluated the effects of an α2‐agonist (clonidine) and an α2‐antagonist (yohimbine) on MPTP‐induced striatal DA depletion and tyrosine hydroxylase activity reduction. We show that clonidine is able to prevent the neurotoxicity of MPTP in mice. To exert this effect, clonidine (0.5 mg/kg) must be administered at least twice (30 min before and 30 min after MPTP). Administration of another α2‐agonist (detomidine, 0.3 mg/kg) attenuated the neurotoxicity induced by MPTP. We provide evidence that the protective effect obtained with clonidine was not due to decreased striatal content of 1‐methyl‐4‐phenylpyridinium (MPP+). We also show that yohimbine, which is a classic α2‐adrenoceptor antagonist with low affinity for imidazoline receptors, produced by itself an enhancement of MPTP toxicity and was able to block the protective effect of clonidine. These data raise the possibility that α2‐adrenoceptor may modulate the susceptibility of the nigrostriatal dopaminergic pathway to neurotoxicity.
Terminologie et paramètres expérimentaux pour l’évaluation des résumés automatiques [Terminology and experimental parameters for the evaluation of automatic summaries]

In this paper, we first propose a terminology to be used in the French pre sentation of evaluation results of automatic summaries. In the second part of the pa per, we describe experimental parameters that should be included in the presentation of ev aluation results, based on the analysis of twenty-two experiments in summarization evaluation. Thes e experimental parameters are pieces of information about the evaluation design. As well, we point out the most popular trends and methodological problems associated with these p arameters and give
A design method for embedded self-testing t-UED and BUED code checkers

A novel method for designing t-UED and BUED code checkers is presented. In particular we consider Borden codes for t = 2/sup k/ - 1, Bose and Bose-Lin codes. The design technique for all three checker types is mainly based on averaging weights and check symbol values of the code words. The checkers have a simple and regular structure that does not depend on the set of code words that is provided by the circuit under check. The checkers are very well suited for use as embedded checkers since they are self-testing with respect to single stuck-at faults and almost all combinational faults in a single cell under very weak assumptions. All three checker types can be tested with only 2 or 3 code words.
Quick Thinkers Are Smooth Talkers

Knowledge of social rules helps people engage in socially intelligent behavior (Argyle & Kendon, 1967; Cantor & Kihlstrom, 1987; Lopes et al., 2004), but social knowledge alone is not enough. For example, even when they understand the social demands, people put their foot in their mouth if their dominant response to a situation is socially inappropriate and they have poor inhibitory control (von Hippel & Gonsalkorale, 2005). Consequently, research in social intelligence has also examined capacities that are thought to underlie socially intelligent responding. Some of these capacities are specifically social, such as the ability to read emotions in people’s eyes (Baron-Cohen, Wheelwright, Hill, Raste, & Plumb, 2001), whereas others are general capacities that facilitate social functioning, such as the ability to detect changing contingencies (Ronay & von Hippel, 2015) or inhibit dominant responses (von Hippel & Dunlop, 2005). In the current article we focus on one such general capacity—mental speed—and examine whether it is associated with social functioning. Mental speed is important in most conceptualizations of general intelligence (Sheppard & Vernon, 2008), but it also has the potential to play a role in social intelligence. For example, mental speed allows people to judge situational demands rapidly, consider a wide repertoire of responses within a socially appropriate response window, mask inappropriate initial reactions by rapidly presenting a nondominant response, and make time-sensitive humorous associations. These capacities could enable a person to be socially sensitive and charismatic. If mental speed plays such a role, then it should predict social skills and charisma, and this relationship should be independent of general intelligence and personality differences. The goal of the current research was to test this possibility.
The evolutionary basis of premature migration in Pacific salmon highlights the utility of genomics for informing conservation

Accounting for specific alleles can be necessary to prevent the loss of significant biodiversity and ecosystem services. The delineation of conservation units (CUs) is a challenging issue that has profound implications for minimizing the loss of biodiversity and ecosystem services. CU delineation typically seeks to prioritize evolutionary significance, and genetic methods play a pivotal role in the delineation process by quantifying overall differentiation between populations. Although CUs that primarily reflect overall genetic differentiation do protect adaptive differences between distant populations, they do not necessarily protect adaptive variation within highly connected populations. Advances in genomic methodology facilitate the characterization of adaptive genetic variation, but the potential utility of this information for CU delineation is unclear. We use genomic methods to investigate the evolutionary basis of premature migration in Pacific salmon, a complex behavioral and physiological phenotype that exists within highly connected populations and has experienced severe declines. Strikingly, we find that premature migration is associated with the same single locus across multiple populations in each of two different species. Patterns of variation at this locus suggest that the premature migration alleles arose from a single evolutionary event within each species and were subsequently spread to distant populations through straying and positive selection. Our results reveal that complex adaptive variation can depend on rare mutational events at a single locus, demonstrate that CUs reflecting overall genetic differentiation can fail to protect evolutionarily significant variation that has substantial ecological and societal benefits, and suggest that a supplemental framework for protecting specific adaptive variation will sometimes be necessary to prevent the loss of significant biodiversity and ecosystem services.
A guide to time-resolved and parameter-free measures of spike train synchrony

Measures of spike train synchrony have proven a valuable tool in both experimental and computational neuroscience. Particularly useful are time-resolved methods such as the ISI- and the SPIKE-distance, which have already been applied in various bivariate and multivariate contexts. Recently, SPIKE-Synchronization was proposed as another time-resolved synchronization measure. It is based on Event-Synchronization and has a very intuitive interpretation. Here, we present a detailed analysis of the mathematical properties of these three synchronization measures. For example, we were able to obtain analytic expressions for the expectation values of the ISI-distance and SPIKE-Synchronization for Poisson spike trains. For the SPIKE-distance we present an empirical formula deduced from numerical evaluations. These expectation values are crucial for interpreting the synchronization of spike trains measured in experiments or numerical simulations, as they represent the point of reference for fully randomized spike trains.