Miracle-dz/UniFAR-FTUs huggingface dataset:
A Training Program to Improve Neuromuscular and Performance Indices in Female High School Soccer Players

Abstract Noyes, FR, Barber-Westin, SD, Smith, STT, and Campbell, T. A training program to improve neuromuscular and performance indices in female high school soccer players. J Strength Cond Res 27(2): 340–351, 2013—The purpose of this study was to determine if a sports-specific anterior cruciate ligament injury prevention training program could improve neuromuscular and performance indices in female high school soccer players. We combined components from a published knee ligament intervention program for jump and strength training with other exercises and drills to improve speed, agility, overall strength, and aerobic fitness. We hypothesized that this program would significantly improve neuromuscular and athletic performance indices in high school female soccer players. The supervised 6-week program was done 3 d·wk−1 for 90–120 minutes per session on the soccer fields and weight room facilities in area high schools. In phase 1, 62 athletes underwent a video drop-jump test, t-test, 2 vertical jump tests, and a 37-m sprint test before and upon completion of the training program. In phase 2, 62 other athletes underwent a multistage fitness test before and after training. There were significant improvements in the mean absolute knee separation distance (p < 0.0001), mean absolute ankle separation distance (p < 0.0001), and mean normalized knee separation distance (p < 0.0001) on the drop-jump, indicating a more neutral lower limb alignment on landing. Significant improvements were found in the t-test (p < 0.0001), estimated maximal aerobic power (p < 0.0001), 37-m sprint test (p = 0.02), and in the 2-step approach vertical jump test (p = 0.04). This is the first study we are aware of that demonstrated the effectiveness of a knee ligament injury prevention training program in improving athletic performance indices in high school female soccer players. Future studies will determine if these findings improve athlete compliance and team participation in knee ligament injury intervention training.
Molecular dynamics simulations of ion-irradiation induced deflection of 2 D graphene films

Ion-irradiation induced surface stress generation and the resulting deflection of 2D cantilever graphene films is studied using molecular dynamics (MD) simulations. The simulation results show that the free-end deflection is strongly dependent on the kinetic energy of the incident ions. At low incident energies ( 10 eV), the graphene film bends towards the irradiated side (upward deflection in our simulations); a transition from bending towards the irradiated side (upward deflection) to bending away from the irradiated side (downward deflection) occurs when the incident energy is 10 eV; the downward deflection peaks at 50 eV. Further increases of the incident energy cause the magnitude of downward deflection to decrease. The evolution of free-end deflection with respect to the number of incidences is also dependent on the incident energy. The dependence of the deflection behavior of the graphene films on the incident energy revealed by our atomistic simulations suggests the generation of intrinsic stress of different levels in the growing films. Such behavior may be attributed to competing mechanisms of production and annihilation of interstitialand vacancy-like defects in the growing film. Understanding the dependence of thin film deflection on the incident energy provides guidelines for controlling thin film shapes at the nanometer scale using ion-beam machining. Published by Elsevier Ltd.
BIODEGRADATION OF ANILINE BY Enterobacter ludwigii KHA 5 ISOLATED FROM THE SOIL AROUND SHIRAZ REFINERY , IRAN

Aniline is a harmful substance that pollutes the environment and seriously endangers human health. In the present study five different bacteria were enriched and isolated from the soil around Shiraz refinery (Iran) as aniline degrading bacteria. They were identified as Enterobacter ludwigii KH-A5, Raoultella planticola KH-A2, Alcaligenes faecalis KH-A3, Serratia marcescens KH-A4 and Microbacterium barkeri KH-A1 based on 16S rDNA gene sequencing. The highest aniline degradation rate (96%) was observed by E. ludwigii KH-A5. This strain with the greatest amount of minimum inhibitory concentration (MIC) was the most aniline resistant bacterium. The optimum pH and temperature that supported biodegradation of aniline by strain KH-A5 were 7.0 and 28-35 °C, respectively. The maximum growth and biodegradation of aniline by KH-A5 were observed at the initial aniline concentration of 100 mg l. The strain could growth on aniline up to concentration of 700 mg l with the degradation rate of 11%. Further studies demonstrated that the addition of 0.5 g l glucose or potassium nitrate as a second carbon or nitrogen source could slightly enhance the biodegradation efficiency from 96.0% to 99.0%. However, even more addition of glucose or potassium nitrate could not further enhance the biodegradation process but delayed the biodegradation of aniline by the strain KH-A5. It could be concluded that these new strains, particularly E. ludwigii KH-A5, have a potential use for bioremediation of the site contaminated with aniline.
A GEF activity-independent function for nuclear Net1 in Nodal signal transduction and mesendoderm formation

ABSTRACT Net1 is a well-characterized oncoprotein with RhoA-specific GEF activity. Oncogenic Net1, which lacks the first 145 amino acids, is present in the cytosol and contributes to the efficient activation of RhoA and the formation of actin stress fibers in a number of tumor cell types. Meanwhile, wild-type Net1 is predominantly localized in the nucleus at steady state due to its N-terminal nuclear localization sequences, where the function of nuclear Net1 has not been fully determined. Here, we find that zebrafish net1 is expressed specifically in mesendoderm precursors during gastrulation. Endogenous Net1 is located in the nucleus during early embryonic development. Gain- and loss-of-function experiments in zebrafish embryos and mammalian cells demonstrate that, regardless of its GEF activity, nuclear Net1 is critical for zebrafish mesendoderm formation and Nodal signal transduction. Detailed analyses of protein interactions reveal that Net1 associates with Smad2 in the nucleus in a GEF-independent manner, and then promotes Smad2 activation by enhancing recruitment of p300 (also known as EP300) to the transcriptional complex. These findings describe a novel genetic mechanism by which nuclear Net1 facilitates Smad2 transcriptional activity to guide mesendoderm development. Highlighted Article: Net1 associates with Smad2 in the nucleus in a GEF-independent manner and facilitates Smad2 transcriptional activity to guide mesendoderm development in zebrafish.
Dependency, skip-grams, association tensors and machine learning for sentence completion

The aim of this work is to get the best semantic representation of words, using sentence completion as a benchmark for its evaluation. We develop a semantic language model integrating a tensor to represent word co-occurrence statistics, an al-gorithm to transform dependency and skip-gram word-word relations into a sentence relevance vector and we ﬁnally apply machine learning classiﬁcation to improve the accuracy of the model. This model clearly highlights the difference of performances between statistical semantic models of the litterature, including those using hyperparameters inspired by neural network models. It shows the complementarity of dependency and linear context relations and gives a precise measurement of their respective contribution. A fully explicit model yields a performance of 77% of correct word in the sentence, enhanced up to 78.6% by machine learning classiﬁcation, to be compared with a chance level of 20% (one out of ﬁve). Moreover we observe the presence of a bias in a well known sentence completion test set, and we propose a new set of 6000 sentences to the research community for further studies.
Tubulin stimulates adenylyl cyclase activity in C6 glioma cells by bypassing the β‐adrenergic receptor: a potential mechanism of G protein activation

While the cytoskeleton is known to play several roles in the biology of the cell, one role, which has been revealed only recently, is that of a participant in the signal transduction process. Tubulin binds specifically to the α subunits of Gs (stimulatory GTP‐binding regulatory protein of adenylyl cyclase), Gi1 (inhibitory protein of adenylyl cyclase), and Gq and transactivates those molecules through direct transfer of GTP. The relevance of this transactivation process to G proteins which are normally activated by a neurotransmitter‐occupied receptor is the subject of this study. C6 glioma cells, made permeable with saponin, retained tight coupling between Gs and the β‐adrenergic receptor. Although 5‐guanylylimidodiphosphate (GppNHp) was incapable of activating Gs (and subsequently, adenylyl cyclase) in the absence of agonist, tubulin with GppNHp bound (tubulin‐GppNHp) activated adenylyl cyclase with an EC50 of 30 nm. Desensitization of β‐adrenergic receptors by isoproterenol exposure had no effect on the ability of tubulin‐GppNHp to activate Gs and adenylyl cyclase. When the photoaffinity GTP analog, azidoanilido GTP (AAGTP; P3(4‐azidoanilido)‐P1‐5'‐GTP), was added to C6 membranes or permeable C6 cells, it was only weakly incorporated by Gαs in the absence of isoproterenol. When the same concentration of dimeric tubulin with AAGTP bound was introduced, AAGTP was transferred from tubulin to Gαs, activating the latter species. Similar ‘preferential’ activation of Gαs by tubulin‐AAGTP versus the free nucleotide was seen using purified components. Thus, membrane‐associated tubulin may serve to activate Gαs, independent of signals not normally coupled to that protein. Tubulin may act as an agent to link a variety of membrane‐associated signalling systems.
Genetic Determinants of Hearing Loss Associated With Vestibular Schwannomas

Hypothesis: The severity of hearing loss (HL) associated with vestibular schwannomas (VSs) is influenced by genes expressed by the VSs. Background: Hearing loss is the most common presenting symptoms in patients with VSs, yet its pathophysiology remains elusive. Previous studies have suggested that VSs cause HL not only by inducing degeneration of the auditory nerve by compression but also by promoting degeneration of the inner ear. This study aimed to determine whether there is a molecular basis for differences in HL associated with VSs. Methods: Surgical specimens of VSs were collected from 13 patients and were divided into a group associated with good (word recognition >70% and pure-tone average ≤30 dB) or poor hearing. Whole-genome expression profiling of VSs was performed with the Affymetrix GeneChip Human X3P Array. The expression of select genes was validated using real-time quantitative reverse transcription-polymerase chain reaction and immunohistochemistry. Because of a small sample size, exact nonparametric tests were used to assess the association between good versus poor hearing and specific histological features of the tumors and patient demographics. Results: Using gene set enrichment analysis, the chromosomal region 3q27 was found to be significantly different between the 2 groups of tumors. This region includes peroxisomal biogenesis factor 5-like gene, which was underexpressed in VSs with poor hearing. The expression of 3 other genes from different chromosomes was significantly different between the 2 groups: RAD54B, prostate-specific membrane antigen-like, and carcinoembryonic antigen. Conclusion: This study identified several molecular alterations in VSs stratified by hearing. These alterations may determine the severity of HL associated with VSs and may represent potential therapeutic targets to prevent or reduce HL in theses patients.
Fluid-structure analysis of an atherosclerotic coronary artery

A theoretical fluid-structure interaction (FSI) model for the stress field of atherosclerotic coronary arteries are obtained and the influence of various characteristics on the stress distribution in diseased coronary arteries is highlighted. A reliable model is developed (and hence accurate heart attack prediction), the following factors are incorporated: (1) non-Newtonian blood flow; (2) artery’s tapered shape; (3) the micro-calcification of the plaque; (4) blood pulsation. Incorporating these factors in the model makes it possible to accurately predict plaque ruptures. The system is modelled based on a 3D fluid-structure interaction analysis via the finite element method (FEM). Experimental data from previous studies are used to generate a realistic material model. The generated model is utilised as a predictive model for plaque rupture and to determine high risk situations in the coronary arteries. It is shown that incorporating the physiological flow rate in the model, the wall shear stress (WSS) (stresses impose to the plaque from blood) and von Mises stresses (stresses in the plaque) are predicted accurately. Also it is shown that microcalcification increases the von Mises stress substantially in the plaque, when the WSS remains the same. Considering tapered shape of the artery is also shown to be important for predicting correct values of both shear and von Mises stresses.
Transplantation Procedures in Children With Primary Hyperoxaluria Type 1: Outcome and Longitudinal Growth

Background. Cure of the metabolic defect in primary hyperoxaluria type 1 (PH1) is possible with liver transplantation (LTx). Preemptive LTx (PLTx) was promoted to prevent chronic kidney disease due to nephrocalcinosis and urolithiasis. However, timing of this procedure is difficult in view of the heterogeneity of PH1 and effective conservative treatment. Combined liver-kidney transplantation (LKTx) is able to cure metabolic defect and replace renal function at the same time and is effective and indicated for patients with or approaching end-stage renal disease (ESRD). Sometimes a sequential approach for LKTx (first liver, then kidney) has been recommended. Methods. We report on 13 patients with PH1 since 1995 who underwent transplantation procedures in our center for PH1 at a median age of 4.7 (range 1.4–8.9) years. Results. The first two patients, planned for a sequential strategy, died early after LTx because of infectious complications. Four patients underwent PLTx at a median glomerular filtration rate of 65 (range 27–98) mL/min/1.73 m2/day (Hoppe et al., Pediatr Nephrol 1996; 10: 488), and three patients still have sufficient residual renal function after a follow-up of median 11.6 years. Seven patients with ESRD received a combined LKTx, including four with infantile oxalosis, and three weighing less than 10 kg. There was no mortality and catch-up growth was observed in most patients. Conclusion. In summary and conclusion, transplantation procedures are challenging in PH1, but our results including growth data are encouraging. PLTx remains an option despite the difficulties in timing the procedure. LKTx is indicated for patients with ESRD and is possible even in patients with infantile oxalosis and may improve longitudinal growth.
Mobility of rectangular plate with constraint and unconstraint edges

Several theories have been established in calculating the mobility of rectangular plate. However, there is still a lacking of discussion on the mobility of plate with various boundary conditions. In this paper, modal summation approach is used to present the mobility of rectangular plates with various constraint and unconstraint edges to discuss their effect on the level of vibration across the frequency range. It is found that at very low frequency (1-20 Hz) that the more constraint the edges the lower the mobility.
MORPHOLOGICAL STUDIES OF ELECTRICAL TREE DUE TO HIGH ALTERNATING ELECTRIC FIELDS IN EPOXY SOLID DIELECTRICS

In polymeric insulation system electrical treeing phenomenon is the significant cause for the failure of the insulating material. The treeing phenomenon in insulators is strongly related to the type of insulator and the nature of flaw in the insulator during the manufacturing process. In this research Epoxy resin samples are prepared to carryout electrical treeing studies under High alternating electric fields of power frequency (50Hz). Needle plane electrode configuration is used to investigate the electrical tree growth characteristics. Partial discharge (PD) patterns during the initiation and propagation are obtained from PD measurement system. The correlation between the electrical tree propagation and the Partial discharge phenomenon is discussed. The morphological patterns during the tree growth are studied and the physical aspects of degradation during tree growth are analyzed in correlation with the partial discharge patterns obtained during the treeing process.
Vitamin D receptor FokI, BsmI, TaqI, ApaI, and EcoRV polymorphisms and susceptibility to melanoma: a meta-analysis.

PURPOSE The purpose of this study was to examine whether vitamin D receptor (lVDR) polymorphisms are associated with susceptibility to melanoma. METHODS A meta-analysis was carried out to investigate the association between the VDR FokI, BsmI, TaqI, ApaI, and EcoRV polymorphisms and susceptibility to melanoma. RESULTS A total of 11 studies were evaluated, which included 4,413 patients and 4,072 controls (all European). The meta-analysis revealed no association between melanoma and the BsmI B allele (odds ratio/OR=0.901, 95% confidence interval/CI=0.783-1.036, p=0.144). However, an association was shown between melanoma and the Bb+bb genotype (OR=0.868, 95% CI=0.767-0.982, p=0.025). No association was noticed between melanoma and FokI polymorphism (OR for the F allele=1.016, 95% CI=0.869-1.189, p=0.839). Moreover, melanoma risk was not associated with the TaqI, ApaI, and EcoRV polymorphisms (OR for the T allele=0.986, 95% CI=0.842-1.156, p=0.864; OR for the A allele=0.949, 95% CI=0.842-1.069, p=0.388; OR for the E allele=0.993, 95% CI=0.875-1.126, p=0.911, respectively). CONCLUSIONS This meta-analysis demonstrated that the VDR BsmI polymorphism is associated with susceptibility to melanoma in Europeans, suggesting that carrying the VDR BsmI B allele may be a protective factor against melanoma development.
Screening of Oleaginous Microorganisms from Filamentous Fungi for Microbial Lipids Production

Some filamentous fungi were screened as potential oleaginous microorganisms for production of microbial lipid. The results showed that filamentous fungus Strain SCIM04 displayed the most potential ability in producing microbial lipid, the lipid content of cells reached 50.93%, and the lipid yield was 8.4±±0.42 g /L. Furthermore, the components profile of the lipid were analyzed. The results revealed that the lipid was abundant in saturated long chain fatty acids (C16: 0) and low degree unsaturated long chain fatty acid (C18: 1), suggesting the lipid could be used for biodiesel production. The optimum media for the biomass and lipid production by the strain were maltose as carbon source with initial concentration 60 g/L, NaNO3 as nitrogen source at 3.0 g/L. The lipid content of cells highly reached 59.9%, and the lipid yield was 10.9±±0.38 g/L, in the optimized media
The role of elastic energy storage and recovery in downhill and uphill running

SUMMARY In level running, humans and other animals store and recover elastic energy during each step. What role does elastic energy play during downhill and uphill running? We measured the fluctuations of the mechanical energy of the center of mass (CoM) of 15 human participants running at 3 m s–1 on the level, downhill and uphill on a force-measuring treadmill mounted at 3, 6 and 9 deg. In level running, nearly symmetrical decreases and increases of the combined gravitational potential and kinetic (GPE+KE) energy of the CoM indicated equal possible elastic energy storage and recovery. However, asymmetrical fluctuations during hill running indicate reduced maximum possible elastic energy storage and return. We analyzed mechanical energy generation and dissipation during level and hill running by quantifying the anatomically estimated elastic energy storage (AEEE) in the arch and Achilles' tendon using peak ground reaction forces and anatomical characteristics. AEEE did not change with grade. At shallow downhill grades, the body must generate mechanical energy, though it dissipates more than it generates. At steeper downhill grades, little to no energy generation is required and only mechanical energy dissipation must occur. The downhill grade at which mechanical energy must no longer be generated occurs at approximately –9 deg, near the metabolically optimal running grade. At shallow uphill grades, mechanical energy must be generated to raise the CoM, and at steeper grades, additional energy must be generated to offset reduced elastic energy storage and return.
Detailed analysis of reactive oxygen species induced by visible light in various cell types

Light in the visible and near infrared region stimulates various cellular processes, and thus has been used for therapeutic purposes. One of the proposed mechanisms is based on cellular production of reactive oxygen species (ROS) in response to illumination. In the present study, we followed visible light (VL)‐induced hydroxyl radicals in various cell types and cellular sites using the electron paramagnetic resonance (EPR) spin‐trapping technique.
MENTAL HEALTH CONDITIONS IN AUSTRALIAN ABORIGINAL AND TORRES STRAIT ISLANDER (ATSI) INDIVIDUALS - SOCIAL, CULTURAL DETERMINANTS AND PREVENTION STRATEGIES INTRODUCTION Australian Aboriginal and Torres Strait Islander (ATSI) are the indigenous population of Australia. Improvement in the state of healt

Australian Aboriginal and Torres Strait Islander (ATSI) are the indigenous population of Australia. Improvement in the state of health in indigenous population has been a challenge in the countries like Australia. It has been observed that social determinants play an important role in population health and health inequity. The important social determinants of health inequality in indigenous population are lack of accessibility to primary health care, poor housing and sanitation, lack of healthy food and safe water.
Preparation of Nucleoside-LDL-Conjugates for the Study of Cell-Selective Internalization: Stability Characteristics and Receptor Affinity

Antiviral therapy of human immunodeficiency virus (HIV) infection is currently based on inhibition of reverse transcriptase by dideoxynucleosides, such as azidothymidine. Because of widespread toxicity it is reasonable to selectively target these drugs to infected cells. This may be accomplished utilizing drug-LDL conjugates, which are internalized via cell specific receptor pathways. With respect to HIV infection, scavenger receptors of the macrophage system seems to offer a hopeful perspective. This pathway requires chemical modification of surface polarity of the LDL. Cell experiments were conducted in HepG2 hepatocytes, which express apolipoprotein B receptors, and in P388 macrophages, which express scavenger receptors. LDL particles to be conjugated were isolated from blood donor plasma and from LDL-apheresis waste material. Non-covalent LDL conjugation with amphiphilic nucleoside derivatives produced only an unspecific nucleoside transfer to cell membranes, due to instability of the LDL conjugates. An experimental method (coincubation test) was developed to identify those conjugates that are stable in the presence of other lipophilic compartments. Covalent coupling of nucleosides to the apolipoprotein B moiety of LDL particles resulted in stable conjugates. As a consequence, the surface charge became negative, and the LDL displayed scavenger receptor affinity rather than apolipoprotein B receptor affinity. Selective targeting of nucleosides to macrophages can be accomplished by covalent coupling to LDL.