Miracle-dz/UniFAR-FTUs huggingface dataset:
MOZ-TIF2 Fusion Protein Binds to Histone Chaperon Proteins CAF-1A and ASF1B Through Its MOZ Portion

We previously identified a MOZ-TIF2 (transcriptional intermediary factor 2) fusion gene from a young female patient with acute myeloid leukemia (AML) (Liang et al., 1998). MOZ related chromosome translocations include MOZ-CREB-binding protein (MOZ-CBP, t(8;16)(p11;p13)), MOZ-P300(t(8;22)(p11;q13)), MOZ-TIF2(inv(8)(p11q13), and MOZNCOA3(t(8;20)(p11;q13)) (Esteyries et al., 2008; Troke et al., 2006). In an animal model, the MOZ-TIF2 fusion product successfully induced the occurrence of AML (Deguchi et al., 2003). Though the mechanisms for leukemogenesis of this fusion protein are poorly understood, analysis of functional domains in the MOZ-TIF2 fusion protein discloses at least two distinct functional domains: 1) the MYST domain containing the C2HC nucleosome recognition motif and the histone acetyltransferase motif in the MOZ portion and 2) the CID domain containing two CBP binding motifs in the TIF2 portion. Together these domains were responsible for AML in mice caused by injecting bone marrow cells transduced with retrovirus containing the MOZ-TIF2 fusion gene. Furthermore, MOZ-TIF2 conferred the properties of leukemic stem cells (Huntly et al., 2004). The MOZ-TIF2 transduced mouse common myeloid progenitors and granulocyte-monocyte progenitors exhibited the ability to serially replated in vitro. The cell line derived from transduced progenitors could induce AML in mice. Interestingly, the C543G mutation in C2HC nucleosome recognition motif or in the CBP binding motif (LXXLL) blocked the self-renewal function of MOZ-TIF2 transduced progenitors. More recently, a study using PU.1 deficient mice demonstrated that the interaction between MOZ-TIF2 and PU.1 promoted the expression of macrophage colony–stimulating factor receptor (CSF1R). Cells with high expression of CSF1R are potential leukemia initiating cells(Aikawa et al., 2010). Models suggesting that aberrant transcription by the interaction between MOZ fusion proteins and transcription factors, AML1, p53, PU1, or NF-kB have been well reviewed(Katsumoto et al., 2008).
Information-theoretic heterogeneity measurement for SAR imagery

A heterogeneity feature, calculable from synthetic aperture radar (SAR) images on a per-pixel basis, but relying on global image statistics, is defined and discussed. Starting from the multiplicative speckle and texture models relating the amount of texture and speckle to the local mean and variance at every pixel, such a feature is rigorously derived from Shannon's information theory as the conditional information of local standard deviation to local mean. Thanks to robust statistical estimation, it is very little sensitive to the noise affecting SAR data, and thus capable of capturing subtle variations of texture whenever they are embedded in a heavy speckle. Experimental results carried out on two SAR images with different degrees of noisiness demonstrate that the proposed feature is likely to be useful for a variety of automated segmentation and classification tasks.
Evaluation of cost of disease: Assessing the burden to society of asthma in children in the European Union

Asthma and allergies have become increasingly prevalent over the last few decades throughout the WHO European Region, with an average of more than 10% of children suffering from asthmatic symptoms. Asthma is one of the most common chronic diseases and it is a complex and heterogeneous disorder where genetics and environment play an interacting role. Childhood asthma is a major global health problem, which exerts a substantial burden on family, health care, and society as a whole. In decision-making on interventions to reduce the burden of childhood asthma an overview of the cost-of-illness of childhood asthma is an essential first step. In this report the cost-of-illness of childhood asthma in the countries of the European Union is assessed by order of the European Commission. Also the countries that will enter the European Union at the 1st of May 2004 are included. The 25 countries of the European Union (EU25) from May 1st 2004 onwards are Austria*, Belgium*, Cyprus, Czech Republic, Denmark*, Estonia, Finland*, France*, Germany*, Greece*, Hungary, Ireland*, Italy*, Latvia, Lithuania, Luxembourg*, Malta, Poland, Portugal*, Slovenia, Slovakia, Spain*, Sweden*, The Netherlands* and the United Kingdom*.
Moral Credentialing and the Rationalization of Misconduct

Recent studies lead to the paradoxical conclusion that the act of affirming one's egalitarian or prosocial values and virtues might subsequently facilitate prejudiced or self-serving behavior, an effect previously referred to as “moral credentialing. ” The present study extends this paradox to the domain of academic misconduct and investigates the hypothesis that such an effect might be limited by the extent to which misbehavior is rationalizable. Using a paradigm designed to investigate deliberative and rationalized forms of cheating (von Hippel, Lakin, & Shakarchi, 2005), we found that when participants had credentialed themselves (vs. a nonclose acquaintance) via a set of hypothetical moral dilemmas, they were more likely to cheat on a subsequent math task, but only if cheating was highly rationalizable. When cheating was difficult to rationalize, moral credentialing had almost no impact on cheating.
RESOLUTION IMPROVEMENT OF ULTRASOUND IMAGES USING DECONVOLUTION AND SUPER-RESOLUTION ALGORITHMS

Ultrasound imaging is a wide spread technique used to view body soft tissues, like tendons, muscle or internal organs for possible problems. These images are achieved by capturing the returned acoustic waves using an ultrasonic transducer. Due to the propagation in imperfect environment, the resolution of these images has a poor quality. This is caused by different problems like waves refraction, attenuations in tissues, destructive waves, bad contacts, and so on. This paper intends to achieve a preliminary synthesis of the most important directions of study for the resolution improvement. We present two important methods for ultrasound image processing: deconvolution based and super-resolution algorithms. Some simulation results are also delivered.
Social Preference in Preschoolers: Effects of Morphological Self-Similarity and Familiarity

Adults prefer to interact with others that are similar to themselves. Even slight facial self-resemblance can elicit trust towards strangers. Here we investigate if preschoolers at the age of 5 years already use facial self-resemblance when they make social judgments about others. We found that, in the absence of any additional knowledge about prospective peers, children preferred those who look subtly like themselves over complete strangers. Thus, subtle morphological similarities trigger social preferences well before adulthood.
Fuzzy logic based direct torque control of induction motor

“The design of this project for induction motor can transform the nonlinear torque-speed characteristics of induction motor to constant torque-speed characteristics similar to that of a DC motor. ” This project is meant to control the torque of induction motor using fuzzy logic controllers by Direct Torque Control (DTC). DTC method yields slow response during start up and change in either direction of torque and flux. Also large and small errors in flux and torque are not distinguishable so to overcome these drawbacks, fuzzy logic is applied to DTC method. Standard applications account for 70% of all variable speed drives installed throughout industry. Two of the most common applications are in fans and pumps in industries like Heating, Ventilating and Air Conditioning etc. In these applications, DTC provides solutions to problems like harmonics and noise. In this project we have used fuzzy logic based duty ratio controller whose optimum duty ratio is determined every switching period for the inverter[1]. The simulation of the project is done by programming in Matlab. The computer simulated results verify the validity of this novel method.
Highly conserved RNA pseudoknots at the gag-pol junction of HIV-1 suggest a novel mechanism of −1 ribosomal frameshifting

−1 programmed ribosomal frameshifting (PRF) is utilized by a large number of viruses to synthesize the viral enzymatic (Pol) and structural (Gag) proteins at a defined ratio. For efficient −1 PRF, two cis-acting elements are often required: a heptanucleotide frameshift site and a downstream stimulator, often in the form of a pseudoknot. The sequences at the gag-pol junctions from 4254 different HIV-1 strains were analyzed. Approximately ninety-five percent of the sequences have the potential to form four pseudoknots PK1–PK4 (∼97% contain PK1, PK3, and PK4). A novel mechanism is suggested for the possible roles of these pseudoknots that incorporates several exquisite new features while being consistent with the current paradigm of pseudoknot-dependent −1 PRF.
Design of ∆ Σ Converters via Sampled-Data H ∞ Optimization

In this paper, we propose a new method for designing ∆Σ converters via sampled-data H∞ optimal control. The design consists of two steps. One is that for ∆Σ modulators. In ∆Σ modulators, the accumulator 1/(z−1) is conventionally used in a feedback loop to attenuate quantization noise. In contrast, we give all stabilizing controllers for the modulator, and propose an H∞ design to shape the frequency response of the system from the noise to the output. The other is a design for multirate filters in oversampling AD/DA converters. While conventional designs are executed in the discrete-time domain, we take account of the characteristic of the original analog signal by using sampled-data H∞ optimization. Design examples are presented to show that our design is superior to conventional ones.
DNN i-Vector Speaker Verification with Short, Text-Constrained Test Utterances

We investigate how to improve the performance of DNN ivector based speaker verification for short, text-constrained test utterances, e.g. connected digit strings. A text-constrained verification, due to its smaller, limited vocabulary, can deliver better performance than a text-independent one for a short utterance. We study the problem with “phonetically aware” Deep Neural Net (DNN) in its capability on “stochastic phonetic-alignment” in constructing supervectors and estimating the corresponding i-vectors with two speech databases: a large vocabulary, conversational, speaker independent database (Fisher) and a small vocabulary, continuous digit database (RSR2015 Part III). The phonetic alignment efficiency and resultant speaker verification performance are compared with differently sized senone sets which can characterize the phonetic pronunciations of utterances in the two databases. Performance on RSR2015 Part III evaluation shows a relative improvement of EER, i.e., 7.89% for male speakers and 3.54% for female speakers with only digit related senones. The DNN bottleneck features were also studied to investigate their capability of extracting phonetic sensitive information which is useful for text-independent or textconstrained speaker verifications. We found that by tandeming MFCC with bottleneck features, EERs can be further reduced.
Pax6 Regulates the Proglucagon Processing Enzyme PC2 and Its Chaperone 7B2

ABSTRACT Pax6 is important in the development of the pancreas and was previously shown to regulate pancreatic endocrine differentiation, as well as the insulin, glucagon, and somatostatin genes. Prohormone convertase 2 (PC2) is the main processing enzyme in pancreatic α cells, where it processes proglucagon to produce glucagon under the spatial and temporal control of 7B2, which functions as a molecular chaperone. To investigate the role of Pax6 in glucagon biosynthesis, we studied potential target genes in InR1G9 α cells transfected with Pax6 small interfering RNA and in InR1G9 clones expressing a dominant-negative form of Pax6. We now report that Pax6 controls the expression of the PC2 and 7B2 genes. By binding and transactivation studies, we found that Pax6 indirectly regulates PC2 gene transcription through cMaf and Beta2/NeuroD1 while it activates the 7B2 gene both directly and indirectly through the same transcription factors, cMaf and Beta2/NeuroD1. We conclude that Pax6 is critical for glucagon biosynthesis and processing by directly and indirectly activating the glucagon gene through cMaf and Beta2/NeuroD1, as well as the PC2 and 7B2 genes.
Dual-Source Computed Tomography for Assessing Cardiac Function: A Phantom Study

Purpose:To investigate the influence of heart rate and temporal resolution on the assessment of global ventricular function with dual-source computed tomography (DSCT). Materials and Methods:A dynamic cardiac phantom was repeatedly scanned with a DSCT scanner applying a standardized scan protocol at different heart rates, ranging from 40 to 140 bpm. Images were reconstructed with monosegmental and bisegmental algorithms using data from a single source and from both sources. Ventricular volumes and ejection fraction (EF) were computed by semiautomated analysis. Results were compared with the phantom's real volumes. Interscan, intraobserver, and interobserver variability were calculated. Results:For single-source data reconstruction temporal resolution was fixed to 165 milliseconds, whereas dual-source image reconstructions resulted in a temporal resolution of 83 milliseconds (monosegmental) and 67.7 ± 14.2 milliseconds (bisegmental), respectively. In general, deviation from the phantom's real volumes was less with dual-source data reconstruction when compared with single-source data reconstruction. Comparing dual-source data reconstruction with single-source data reconstruction, the percent deviation from the phantom's real volumes for EF was 0.7% (monosegmental), 0.7% (bisegmental), and 4.3% (single source), respectively. There was no correlation between heart rate and EF for dual-source data reconstruction (r = −0.168; r = −0.157), whereas a relevant correlation was observed for single-source data reconstruction (r = −0.844). Interscan, intraobserver, and interobserver variability for EF were 1.4%, 0.9%, and 0.3%, respectively. Conclusions:DSCT allows reliable quantification of global ventricular function independent of the heart rate. Multisegmental image reconstruction is not needed for DSCT assessment of global ventricular function.
Shared Decision-Making in Nursing Homes

Objective: The advantages of empowering direct care workers (DCWs) within nursing homes (NHs) are well documented. Our objective is to identify factors that create DCW empowerment as this has not received adequate attention. Method: The data come from a larger study focused on the empowerment of DCWs in NHs. A self-administered instrument was completed by 372 DCWs within 11 NHs in the north Texas region. Cluster analysis and ordinary least squares (OLS) regression were performed. Results: Feedback from nurse management to DCWs was positively associated with shared decision-making (SDM) and ranked highest followed by information exchange, trust in management, and wages linked to performance. Discussion: SDM may be enhanced where nurse management shares relevant information with the DCWs, listens to their ideas, provides explanations when DCW suggestions are not used, and does so in a supportive environment. Organizational characteristics of importance include linking wages to DCW performance and providing an accessible training program.
The effect of past condition on a multicomponent sexual signal†

Sexual-selection theory predicts that multiple signals may reveal male condition at different stages of life, thus allowing females to make a more reliable assessment of male quality. While the effect of current condition on signal design is well established, few studies have experimentally investigated the effects of past condition. We therefore manipulated the nutritional condition of male nymph field crickets Gryllus campestris and assessed the enduring effects on multiple components of the adult calling song. Food-restricted males had longer nymphal development times and smaller adult body sizes than nymphs with ad libitum food access. Nymphal feeding conditions specifically affected the allometric relationship between body size and harp size, as food-restricted males developed comparatively small harps, leading to a calling song of higher carrier frequency than that produced by similar-sized control males. Other calling-song components, notably chirp rate and chirp intensity, were not affected by the nymphal food treatment, exposing carrier frequency as the key component indicating past condition. In a previous study we established chirp rate as the sole indicator of current condition. The combined results represent experimental evidence of a multicomponent sexual signal that provides distinct information on male condition during different stages of life.
LDPC Decoder Using Pattern-Dependent Modified LLR for the Bit Patterned Media Storage With Written-In Errors

The written-in errors in bit patterned media recording (BPMR) system cause the erroneous bits during the writing process leading to the performance degradation. In this work, we propose the pattern-dependent modified log-likelihood ratio (LLR) usage in low-density parity check (LDPC) decoder to reduce the written-in errors and also improve the write margin. Unlike the existing works, LLR computed based on the input data patterns is used at the LDPC decoder for the cascaded written-in error channel (WEC) with the additive white Gaussian noise (AWGN) channel. The proposed LDPC decoder outperforms the one with conventional LLR in terms of both the write margin, when the SNR is fixed at 5.5 dB, and the performance of LDPC decoder. The SNR gain is about 0.2 dB at the BER of 10- 6.
Potential of NPP-VIIRS Nighttime Light Imagery for Modeling the Regional Economy of China

Historically, the Defense Meteorological Satellite Program’s Operational Linescan System (DMSP-OLS) was the unique satellite sensor used to collect the nighttime light, which is an efficient means to map the global economic activities. Since it was launched in October 2011, the Visible Infrared Imaging Radiometer Suite (VIIRS) sensor on the Suomi National Polar-orbiting Partnership (NPP) Satellite has become a new satellite used to monitor nighttime light. This study performed the first evaluation on the NPP-VIIRS nighttime light imagery in modeling economy, analyzing 31 provincial regions and 393 county regions in China. For each region, the total nighttime light (TNL) and gross regional product (GRP) around the year of 2010 were derived, and a linear regression model was applied on the data. Through the regression, the TNL from NPP-VIIRS were found to exhibit R2 values of 0.8699 and 0.8544 with the provincial GRP and county GRP, respectively, which are significantly stronger than the relationship between the TNL from DMSP-OLS (F16 and F18 satellites) and GRP. Using the regression models, the GRP was predicted from the TNL for each region, and we found that the NPP-VIIRS data is more predictable for the GRP than those of the DMSP-OLS data. This study demonstrates that the recently released NPP-VIIRS nighttime light imagery has a stronger capacity in modeling regional economy than those of the DMSP-OLS data. These findings provide a foundation to model the global and regional economy with the recently availability of the NPP-VIIRS data, especially in the regions where economic census data is difficult to access.
An Update of pTRIDENT Multicistronic Expression Vectors: pTRIDENTS Containing Novel Streptogramin‐Responsive Promoters

We present an update on the pTRIDENT multicistronic mammalian expression vectors and their implications in various metabolic engineering and therapeutic applications. The pTRIDENT vector family has been expanded by construction of a new set of pTRIDENT‐based vectors containing constitutive promoters of human origin (ubiquitin C and EF‐1α promoters) and selectable markers (zeocin resistance) and expressing different reporter genes (secreted alkaline phosphatase (SEAP) and the secreted single‐chain urokinase‐type plasminogen activator (low‐Mr u‐PA)). In addition, we have constructed pTRIDENT derivatives with novel streptogramin‐repressible and streptogramin‐inducible promoters for simultaneous and adjustable expression of three different transgenes. Streptogramin‐inducible and tetracycline‐repressible pTRIDENT derivatives were used to simultaneously control expression of three fluorescent proteins in mammalian cells: the enhanced cyan fluorescent protein (CFP), the recently isolated red fluorescent protein (RFP, also designated dsRed), and the enhanced yellow fluorescent protein (YFP). Owing to their modular structure, the pTRIDENT vector family represents a construction kit for the design of novel multicistronic expression constructs.
Validation of two devices for self-measurement of blood pressure by elderly patients according to the revised British Hypertension Society protocol: the Omron HEM-722C and HEM-735C.

BACKGROUND The validation of self-measurement devices for clinical use by elderly patients has been recommended. The Omron HEM-722C device has recently been validated according to the British Hypertension Society (BHS) protocol for use for general populations and the Omron HEM-735C is a new fully automatic device with a high capacity for storage of measurements that is integrated with a personal computer. OBJECTIVE To perform a clinical validation for use by elderly people of the Omron HEM-722C and HEM-735C devices according to the revised protocol of the BHS and the criteria of the Association for the Advancement of Medical Instrumentation (AAMI). METHODS We carried out a main validation test according to the revised BHS protocol for validation procedures for special groups on two groups of 30 subjects aged more than 65 years (29 men and 31 women), 11 of 30 with systolic blood pressures (SBP) <110mmHg, 10 of 30 with SBP >200 mmHg, 15 of 30 with diastolic blood pressures (DBP( <70 mmHg and 10 of 30 with DBP >110 mmHg. The results were graded according to the BHS system from A to D. RESULTS The Omron HEM 722C achieved an overall A/A grading and satisfied the AAMI criteria for accuracy whereas the Omron HEM-735C achieved an overall B/A grading and satisfied the AAMI criteria for accuracy. The sphygmomanometer measurements were 147 +/- 31/79 +/- 15 and 144 +/- 30/78 +/- 15 mmHg (means+/-SD) respectively, for the models 722C and 735C. The average differences between mercury sphygmomanometer and HEM-722C readings for SBP and DBP were, respectively, 0.76+/-5 and 0.41+/-8 mmHg; those for HEM-735C were, respectively, 0.24+/-8 and 0.9+/-8 mmHg. Readings of the HEM-722C device differed by less than 5 mmHg for 76% of systolic readings and 96% of the readings differed by less than 10 mmHg. Diastolic measurements differed by less than 5 mmHg for 71% and less than 10 mmHg for 71 and 87% of all readings. Readings of the HEM-735C device differed by less than 5 mmHg for 68% of systolic readings and 74% of the readings differed by less than 10 mmHg. Diastolic measurements differed by less than 5 mmHg in 74% and less than 10 mmHg in 88 and 87% of all readings. CONCLUSIONS On the basis of these results, for elderly subjects both self-measurement devices (Omron HEM-722C and HEM-735C) satisfied the validation criteria of the BHS and therefore can be recommended for the clinical measurement of blood pressure in elderly patients.