Miracle-dz/UniFAR-FTUs huggingface dataset:
A Decision Analysis of Percutaneous Left Atrial Appendage Occlusion Relative to Novel and Traditional Oral Anticoagulation for Stroke Prevention in Patients with New-Onset Atrial Fibrillation

Background. Percutaneous left atrial appendage occlusion (LAAO) is a nonpharmacologic approach for stroke prevention in nonvalvular atrial fibrillation (NVAF). No direct comparisons to novel oral anticoagulants (OACs) exists, limiting decision making on the optimal strategy for stroke prevention in NVAF patients. Addressing this gap in knowledge is timely given the recent debate by the US Food and Drug Administration regarding the effectiveness of LAAO. Objective. To assess the cost-effectiveness of LAAO and novel OACs relative to warfarin in patients with new-onset NVAF without contraindications to OAC. Design. A cost-utility analysis using a patient-level Markov micro-simulation decision analytic model was undertaken to determine the lifetime costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratio (ICER) of LAAO and all novel OACs relative to warfarin. Effectiveness and utility data were obtained from the published literature and cost from the Ontario Drug Benefits Formulary and Case Costing Initiative. Results. Warfarin had the lowest discounted QALY (5.13 QALYs), followed by dabigatran (5.18 QALYs), rivaroxaban and LAAO (5.21 QALYs), and apixaban (5.25 QALYs). The average discounted lifetime costs were $15 776 for warfarin, $18 280 for rivaroxaban, $19 156 for apixaban, $20 794 for dabigatran, and $21 789 for LAAO. Apixaban dominated dabigatran and LAAO and demonstrated extended dominance over rivaroxaban. The ICER for apixaban relative to warfarin was $28 167/QALY. Apixaban was preferred in 40.2% of simulations at a willingness-to-pay threshold of $50 000/QALY. Limitations. Assumptions regarding clinical and methodological differences between published studies of each therapy were minimized. Conclusions. Apixaban is the most cost-effective therapy for stroke prevention in patients with new-onset NVAF without contraindications to OAC. Uncertainty around this conclusion exists, highlighting the need for further research.
A Two-Stream Deep Fusion Framework for High-Resolution Aerial Scene Classification

One of the challenging problems in understanding high-resolution remote sensing images is aerial scene classification. A well-designed feature representation method and classifier can improve classification accuracy. In this paper, we construct a new two-stream deep architecture for aerial scene classification. First, we use two pretrained convolutional neural networks (CNNs) as feature extractor to learn deep features from the original aerial image and the processed aerial image through saliency detection, respectively. Second, two feature fusion strategies are adopted to fuse the two different types of deep convolutional features extracted by the original RGB stream and the saliency stream. Finally, we use the extreme learning machine (ELM) classifier for final classification with the fused features. The effectiveness of the proposed architecture is tested on four challenging datasets: UC-Merced dataset with 21 scene categories, WHU-RS dataset with 19 scene categories, AID dataset with 30 scene categories, and NWPU-RESISC45 dataset with 45 challenging scene categories. The experimental results demonstrate that our architecture gets a significant classification accuracy improvement over all state-of-the-art references.
A review of implicit and explicit substance self-concept as a predictor of alcohol and tobacco use and misuse

ABSTRACT Background: This paper provides an overview of the self-concept as it relates to substance use. Self-concept has a long history in psychological theory and research; however, substance self-concept (e.g., viewing one’s self as a drinker or smoker) is an understudied area of research with the potential to expand existing conceptualizations of substance use, addiction, and prevention and treatment efforts, and should receive greater research attention. Objectives: First, we review and provide a theoretical framework of substance self-concept that draws from dual process models and distinguishes between implicit and explicit self-concept. Next, we summarize key findings related to substance use in the extant literature, focusing on alcohol and tobacco (smoking). Results: Across both substances, there is converging evidence that substance self-concept is associated with substance use outcomes, including quantity and frequency of use and problems associated with use, and that change in substance self-concept is associated with recovery from substance misuse. Recommendations for the substance self-concept research agenda include routine assessment of substance self-concept, expanded use of implicit measures, investigation of moderators of substance self-concept, and targeting substance self-concept directly in prevention and intervention efforts. Conclusion: Ultimately, we suggest that substance self-concept is a promising, but understudied, construct. Greater research attention to substance self-concept could clarify its potential as an important risk factor for hazardous use and addiction as well as its utility as a prevention and treatment target.
New promising strategies in oncofertility

ABSTRACT Introduction: Approximately 70,000 adolescent and young adults (AYA) are diagnosed with cancer each year. While advancements in treatment have led to improved prognosis and survival for patients, these same treatments can adversely affect AYA reproductive capacity. Localized treatments such as surgery and radiation therapy may affect fertility by removing or damaging reproductive organs, and systemic therapies such as chemotherapy can be toxic to gonads, (ovaries and testicles), thus affecting fertility and/or endocrine function. This can be traumatic for AYA with cancer as survivors often express desire to have genetic children and report feelings of regret or depression as a result of infertility caused by cancer treatments. Areas covered: Emerging technologies in the field of assisted reproductive technology offer new promise for preserving the reproductive capacity of AYA cancer patients prior to treatment as well as providing alternatives for survivors. The following review revisits contemporary approaches to fertility preservation as well newly developing technologies. Expert commentary: There are several advances in ART that hold promise for patients and survivors. However there are challenges that inhibit uptake including poor communication between providers and patients about risks and fertility preservation options; high costs; and lack of insurance coverage for fertility preservation services.
Cyclic stretch of airway epithelium inhibits prostanoid synthesis.

Airway epithelial cells (AEC) metabolize arachidonic acid (AA) to biologically active eicosanoids, which contribute to regulation of airway smooth muscle tone and inflammatory responses. Although in vivo the airways undergo cyclical stretching during ventilation, the effect of cyclic stretch on airway epithelial AA metabolism is unknown. In this study, cat and human AEC were grown on flexible membranes and were subjected to cyclic stretch using the Flexercell strain unit. Cyclic stretch downregulated synthesis of prostaglandin (PG) E2, PGI2, and thromboxane A2 by both cell types in a frequency-dependent manner. The percent inhibition of prostanoid synthesis in both cell types ranged from 53 ± 7 to 75 ± 8% (SE; n = 4 and 5, respectively). Treatment of cat AEC with exogenous AA (10 μg/ml) had no effect on the stretch-induced inhibition of PGE2 synthesis, whereas treatment with exogenous PGH2 (10 μg/ml) overcame the stretch-induced decrease in PGE2 production. These results indicate that stretch inhibits prostanoid synthesis by inactivating cyclooxygenase. When cells were pretreated with the antioxidants catalase (100 μg/ml, 150 U/ml) and N-acetylcysteine (1 mM), there was a partial recovery of eicosanoid production, suggesting that cyclic stretch-induced inactivation of cyclooxygenase is oxidant mediated. These results may have important implications for inflammatory diseases in which airway mechanics are altered.
Do single people want to date a cancer survivor? A vignette study

Objective Qualitative studies indicated that cancer survivors may be worried about finding a partner in the future, but whether this concern is warranted is unknown. We examined single people´s interest in dating a cancer survivor, how they perceive survivors’ traits, and their preferences about the timing of disclosing a cancer history. Methods In three experimental vignette studies, dating website members (n = 324) and college students (n = 138 and n = 131) were randomly assigned to a vignette of a person with or without a history of cancer (experiment 1 & 2), or a cancer survivor beyond or during active follow-up (experiment 3). Respondents rated their interest in dating this fictive person, this person’s traits, and indicated their preferences about the timing of disclosure. ANOVAs with main and interaction effects of condition, gender, and relationship history were conducted, partial eta squared and Cohen’s d were used to estimate the magnitude of effects. Correlations were used to investigate relationships between interest in a date and assessment of traits. Results Cancer survivors’ traits were assessed more positively, but interest to date them did not differ from healthy vignettes for both men and women. However, widowed respondents were much less interested in a date with a cancer survivor, and women showed less interest in a cancer survivor during active follow-up relative to survivors beyond follow-up. Most respondents wanted to hear about the cancer diagnosis after a few dates, hardly anyone wanted to hear about this before the first date (2% - 5%). Conclusion and implications for cancer survivors Cancer survivors do not have to expect any more problems in finding a date than people without a cancer history, and can wait a few dates before disclosing. Survivors dating widowed people and survivors in active follow-up could expect more hesitant reactions and should disclose earlier.
Scalable Methods for Measuring the Connectivity and Quality of Large Numbers of Linked Datasets

Although the ultimate objective of Linked Data is linking and integration, it is not currently evident how connected the current Linked Open Data (LOD) cloud is. In this article, we focus on methods, supported by special indexes and algorithms, for performing measurements related to the connectivity of more than two datasets that are useful in various tasks including (a) Dataset Discovery and Selection; (b) Object Coreference, i.e., for obtaining complete information about a set of entities, including provenance information; (c) Data Quality Assessment and Improvement, i.e., for assessing the connectivity between any set of datasets and monitoring their evolution over time, as well as for estimating data veracity; (d) Dataset Visualizations; and various other tasks. Since it would be prohibitively expensive to perform all these measurements in a naïve way, in this article, we introduce indexes (and their construction algorithms) that can speed up such tasks. In brief, we introduce (i) a namespace-based prefix index, (ii) a sameAs catalog for computing the symmetric and transitive closure of the owl:sameAs relationships encountered in the datasets, (iii) a semantics-aware element index (that exploits the aforementioned indexes), and, finally, (iv) two lattice-based incremental algorithms for speeding up the computation of the intersection of URIs of any set of datasets. For enhancing scalability, we propose parallel index construction algorithms and parallel lattice-based incremental algorithms, we evaluate the achieved speedup using either a single machine or a cluster of machines, and we provide insights regarding the factors that affect efficiency. Finally, we report measurements about the connectivity of the (billion triples-sized) LOD cloud that have never been carried out so far.
Human Leukocyte Antigen Class I Supertypes and HIV-1 Control in African Americans

ABSTRACT The role of human leukocyte antigen (HLA) class I supertypes in controlling human immunodeficiency virus type 1 (HIV-1) infection in African Americans has not been established. We examined the effects of the HLA-A and HLA-B alleles and supertypes on the outcomes of HIV-1 clade B infection among 338 African American women and adolescents. HLA-B58 and -B62 supertypes (B58s and B62s) were associated with favorable HIV-1 disease control (proportional odds ratio [POR] of 0.33 and 95% confidence interval [95% CI] of 0.21 to 0.52 for the former and POR of 0.26 and 95% CI of 0.09 to 0.73 for the latter); B7s and B44s were associated with unfavorable disease control (POR of 2.39 and 95% CI of 1.54 to 3.73 for the former and POR of 1.63 and 95% CI of 1.08 to 2.47 for the latter). In general, individual alleles within specific B supertypes exerted relatively homogeneous effects. A notable exception was B27s, whose protective influence (POR, 0.58; 95% CI, 0.35 to 0.94) was masked by the opposing effect of its member allele B*1510. The associations of most B supertypes (e.g., B58s and B7s) were largely explained either by well-known effects of constituent B alleles or by effects of previously unimplicated B alleles aggregated into a particular supertype (e.g., B44s and B62s). A higher frequency of HLA-B genotypic supertypes correlated with a higher mean viral load (VL) and lower mean CD4 count (Pearson's r = 0.63 and 0.62, respectively; P = 0.03). Among the genotypic supertypes, B58s and its member allele B*57 contributed disproportionately to the explainable VL variation. The study demonstrated the dominant role of HLA-B supertypes in HIV-1 clade B-infected African Americans and further dissected the contributions of individual class I alleles and their population frequencies to the supertype effects.
A three-phase off-line UPS system for transformer coupled loads

: A number of critical load applications depend on a UPS system to uphold the normal operation. As soon as any disruption happens on the utility, an off-line UPS system starts supplying the power to the load to prevent blackout. Nonetheless, during this process, a substantial inrush current can be observed for the transformer-coupled loads. To avoid this inrush current, we propose an off-line UPS system based on a current regulated voltage source inverter. The inverter of the proposed UPS system uses a current control scheme executed in a stationary frame to regulate the load current and eliminates the likelihood of the inrush current. To endorse the performance of the proposed UPS system, we constructed a small prototype to obtain the experimental results.
Characterization of CFTR expression and chloride channel activity in human endothelia.

The cystic fibrosis transmembrane conductance regulator (CFTR) functions as a low-conductance, cAMP-regulated chloride (Cl-) channel in a variety of cell types, such as exocrine epithelial cells. Our results demonstrate that human primary endothelial cells isolated from umbilical vein (HUVEC) and lung microvasculature (HLMVEC) also express CFTR as determined via RT-PCR and immunohistochemical and immunoprecipitation analyses. Moreover, Cl- efflux and whole cell patch-clamp analyses reveal that HUVEC ( n = 6 samples, P < 0.05) and HLMVEC ( n = 5 samples, P < 0.05) display cyclic nucleotide-stimulated Cl-transport that is inhibited by the CFTR selective Cl- channel blocker glibenclamide but not by the blocker DIDS, indicative of CFTR Cl- channel activity. Taken together, these findings demonstrate that human endothelial cells derived from multiple organ systems express CFTR and that CFTR functions as a cyclic nucleotide-regulated Cl- channel in human endothelia.
Effect of oral exposure to acrylamide on biochemical and hematologic parameters in Wistar rats

Abstract The toxic effects of ACR monomer include carcinogenesis, cellular genotoxic, and neurotoxicity. In this study, we examined the effect of acrylamide on biochemical and hematologic parameters in Wistar rats and explored the renal and hepatic function of these animals through a complementary anatomopathologic study. For it, thirty female Wistar rats aged 4 weeks and weighing 100 ± 10 g were housed six animals per cage and divided as follows: two groups were exposed for 2 months to drinking water containing 5 mg (Group 2) or 10 mg acrylamide (Group 3); one group of 12 rats received the median lethal dose of acrylamide by gavage (Group 4); and the control group (Group 1) received pure water. The results clearly showed that acrylamide affects various biochemical parameters, such as creatinine, urea, and serum globulin levels and the lipid balance, which are directly related to renal and hepatic dysfunction and disruption of the hematologic system. In addition, the data revealed changes in the complete blood count (CBC); significant increases in the number of leukocytes (9.95 ± 1.44 and 10.44 ± 1.21) and lymphocytes (6.11 ± 0.48 and 6.33 ± 0.76) in Groups 3 and 4, respectively; and decreases in total protein (88.95 ± 6.36), albumin (37.65 ± 1.65) and α-1 globulin levels (24.84 ± 2.10) in Group 3. The anatomopathologic study confirmed liver damage in the animals administered an acrylamide containing diet compared with those in the control group. The present study confirmed the effects of acrylamide on different hematologic, biochemical and immunologic parameters, with a specific focus on the liver and kidney, and on the induction of neurotoxic disorders. The results showed that oral exposure to acrylamide via drinking water or gavage induces kidney damage, hepatocellular insufficiency and chronic liver disease, resulting in primary immunodeficiency and activation of the immune system following the possible expression of certain immunoreaction genes.
Caloric Restriction‐Induced Decreases in Dopamine Receptor Availability are Associated with Leptin Concentration

It has been previously reported that early after Roux‐en‐Y‐gastric bypass, dopamine (DA) type 2 and 3 receptor (D2/3R) binding potential (BPND) was decreased from preoperative levels. The current study aimed to determine whether calorie restriction without weight loss modifies D2/3R BPND and whether such changes are explained by neuroendocrine regulation.
JSEFT: Automated Javascript Unit Test Generation

The event-driven and highly dynamic nature of JavaScript, as well as its runtime interaction with the Document Object Model (DOM) make it challenging to test JavaScript-based applications. Current web test automation techniques target the generation of event sequences, but they ignore testing the JavaScript code at the unit level. Further they either ignore the oracle problem completely or simplify it through generic soft oracles such as HTML validation and runtime exceptions. We present a framework to automatically generate test cases for JavaScript applications at two complementary levels, namely events and individual JavaScript functions. Our approach employs a combination of function coverage maximization and function state abstraction algorithms to efficiently generate test cases. In addition, these test cases are strengthened by automatically generated mutation-based oracles. We empirically evaluate the implementation of our approach, called JSEFT, to assess its efficacy. The results, on 13 JavaScript-based applications, show that the generated test cases achieve a coverage of 68% and that JSEFT can detect injected JavaScript and DOM faults with a high accuracy (100% precision, 70% recall). We also find that JSEFT outperforms an existing JavaScript test automation framework both in terms of coverage and detected faults.
A safer, urea-based in situ hybridization method improves detection of gene expression in diverse animal species

In situ hybridization is a widely employed technique allowing spatial visualization of gene expression in fixed specimens. It has proven to be essential to our understanding of biological processes, including developmental regulation. In situ protocols are today routine in numerous laboratories, and although details might change, they all include a hybridization step, where specific antisense RNA or DNA probes anneal to the target nucleic acids strand. This step, in general, is carried out at high temperatures and in a denaturing solution, the hybridization buffer, commonly containing 50% (v/v) formamide. An important drawback is that hot formamide poses a significant health risk and so must be handled with great care. We were prompted to test alternative hybridization solutions for in situ detection of gene expression in the medusa of the hydrozoan Clytia hemisphaerica, where traditional protocols caused extensive deterioration of the morphology and texture during hybridization, hindering observation and interpretation of results. Inspired by optimized protocols for Northern and Southern blot analysis, we substituted the 50% formamide with an equal volume of 8 M urea solution in the hybridization buffer. The new protocol yielded better morphologies and consistency of tissues, and also notably improved the resolution of the signal, allowing more precise localization of gene expression, as well as reduced staining at non-specific sites. Given the improved results using a less toxic hybridization solution, we tested the urea protocol on a number of other metazoans: two brachiopod species (Novocrania anomala and Terebratalia transversa) and the worm Priapulus caudatus, obtaining a similar reduction of aspecific probe binding. Overall, substitution of formamide by urea in in situ hybridization offers safer alternative protocols, potentially useful in research, medical and teaching contexts. We encourage other workers to test this approach on their study organisms, and hope that they will also obtain better sample preservation, more precise expression patterns and fewer problems due to aspecific staining, as we report here for Clytia medusae and Novocrania and Terebratalia developing larvae.
Life-Span Extension by Axenic Dietary Restriction Is Independent of the Mitochondrial Unfolded Protein Response and Mitohormesis in Caenorhabditis elegans

Abstract In Caenorhabditis elegans, a broad range of dietary restriction regimens extend life span to different degrees by separate or partially overlapping molecular pathways. One of these regimens, axenic dietary restriction, doubles the worm’s life span but currently, almost nothing is known about the underlying molecular mechanism. Previous studies suggest that mitochondrial stress responses such as the mitochondrial unfolded protein response (UPRmt) or mitohormesis may play a vital role in axenic dietary restriction–induced longevity. Here, we provide solid evidence that axenic dietary restriction treatment specifically induces an UPRmt response in C elegans but this induction is not required for axenic dietary restriction–mediated longevity. We also show that reactive oxygen species–mediated mitohormesis is not involved in this phenotype. Hence, changes in mitochondrial physiology and induction of a mitochondrial stress response are not necessarily causal to large increases in life span.
Microstructure of FGH97 P/M superalloy

Microstructure of FGH97 P/M superalloy was investigated and analyzed by means of optical microscopy(OM) and scanning electron microscopy(SEM). The results indicate that the grain size of HIPed(hot isostatic pressed) FGH97 P/M superalloy is uniform with average size of 30-40 μm. Hafnium is effective on reducing PPB(prior particle boundary) and stabilizing carbides in FGH97 superalloy.Hafnium is also distributed in γ′-phase and strengthens γ′-phase.Serration grain boundary is observed in FGH97 superalloy,which is helpful to improve plasticity and ductility of FGH97 P/M superalloy.