Miracle-dz/UniFAR-FTUs huggingface dataset:
LDMOS Technology for RF Power Amplifiers

We show the status of laterally diffused metal-oxide-semiconductor (LDMOS) technology, which has been the device of choice for RF power applications for more than one decade. LDMOS fulfills the requirements for a wide range of class AB and pulsed applications, such as base station, broadcast, and microwave. We present state-of-the-art RF performance of the LDMOS transistor measured with a load-pull test setup, achieving class-AB drain efficiencies of 70% at 2 GHz for on-wafer and packaged devices. Furthermore, the results for several class-AB and Doherty amplifier implementations constructed with this technology are shown. As an illustration, a three-way Doherty application is demonstrated, which has a 7.5-dB back-off efficiency of 47% at 1.8 GHz with a peak power of 700 W and linearity numbers better than -65 dBc.
Prognosis of White-coat and Masked Hypertension International Database of Home Blood Pressure in Relation to Cardiovascular Outcome on Behalf of the International Database on Home Blood Pressure in Relation to Cardiovascular Outcome (idhoco) Investigators Epidemiology/population

C onventional measurement of blood pressure (BP) at the doctor's office is considered as the standard method for hypertension diagnosis and management. 1 However, white-coat and masked hypertension phenomena are common in both untreated and treated patients. Assessment of out-of-office BP with ambulatory or home monitoring is therefore necessary for an accurate diagnosis and management. 1 According to the European Society of Hypertension recommendations , white-coat and masked hypertension can be diagnosed using ambulatory or home BP measurements, with See Editorial Commentary, pp 670–671 Abstract—Home blood pressure monitoring is useful in detecting white-coat and masked hypertension and is recommended for patients with suspected or treated hypertension. The prognostic significance of white-coat and masked hypertension detected by home measurement was investigated in 6458 participants from 5 populations enrolled in the International Database of HOme blood pressure in relation to Cardiovascular Outcomes. During a median follow-up of 8.3 years, 714 fatal plus nonfatal cardiovascular events occurred. Among untreated subjects (n=5007), cardiovascular risk was higher in those with white-coat hypertension (adjusted hazard ratio 1. compared with normotensive subjects. Among treated patients (n=1451), the cardiovascular risk did not differ between those with high office and low home blood pressure (white-coat) and treated controlled subjects (low office and had higher cardiovascular risk than treated controlled patients. In conclusion, white-coat hypertension assessed by home measurements is a cardiovascular risk factor in untreated but not in treated subjects probably because the latter receive effective treatment on the basis of their elevated office blood pressure. In contrast, masked uncontrolled hypertension is associated with increased cardiovascular risk in both untreated and treated patients, who are probably undertreated because of their low office blood pressure.
The US Department of Defense Millennium Cohort Study: Career Span and Beyond Longitudinal Follow-Up

Objective: To describe current and future career-span health research in the US Department of Defense Millennium Cohort Study. Methods: Collaborating with all military service branches and the Department of Veterans Affairs, the Millennium Cohort Study launched in 2001, before September 11 and the start of deployments in Afghanistan and Iraq, to conduct coordinated strategic research to determine any effects of military occupational and deployment-related exposures, on long-term health. Results: More than 150,000 consenting members represent demographic, occupational, military, and health characteristics of the US military. More than 70% of the first two panels have submitted follow-up questionnaires and >50% have deployed since 2001. Conclusions: Prospective cohort data have identified subgroups of military populations at higher risk or more resilient to decrements in mental and physical health. Continued career span and beyond follow-up will answer long-term health questions related to military service.
Dynamic virtual organization management for service oriented enterprise applications

The requirements for dynamic virtual organization management have been derived from an analysis of the state-of-the-art in service-oriented enterprise management systems and its preparedness for handling more complex, long-term business interactions with multilateral agreements. It was found that these forms of business interactions are currently not well supported with respect to dynamic configuration of membership and business interactions based on trust, security and contract parameters. This resulted in an architecture that extends the state-of-the-art enterprise systems architecture, as well as the protocols for managing the state and membership of the dynamic virtual organization
Measuring the effectiveness of a human resource information system in National Iranian Oil Company

Purpose – The purpose of this paper is to examine the impact of three specific variables, namely: system quality, information quality, and finally information use, on the effectiveness of a human resource information system (IS) in an Iranian oil company.Design/methodology/approach – To investigate the effectiveness of a human resource IS, the paper analyzes the end‐user satisfaction based on the DeLone and McLean IS effectiveness model. A methodology is developed that follows a series of steps to calculate the effectiveness of an IS. The questionnaire is designed and refined by expert review. Data from four surveys in four different organizations in the Iranian oil industry are pooled.Findings – Results show that user satisfaction from information quality, system quality, and system use is, respectively, 0.92, 0.82, and 0.91. Therefore, the integrated human resource system in the Iranian oil company has a high degree of effectiveness. Implications of these findings are discussed along with some directions.
Sequential decision making in parallel two-sided economic search

This paper presents a two-sided economic search model in which agents are searching for beneficial pairwise partnerships. In each search stage, each of the agents is randomly matched with several other agents in parallel, and makes a decision whether to accept a potential partnership with one of them. The distinguishing feature of the proposed model is that the agents are not restricted to maintaining a synchronized (instantaneous) decision protocol and can sequentially accept and reject partnerships within the same search stage. We analyze the dynamics which drive the agents' strategies towards a stable equilibrium in the new model and show that the proposed search strategy weakly dominates the one currently in use for the two-sided parallel economic search model. By identifying several unique characteristics of the equilibrium we manage to efficiently bound the strategy space that needs to be explored by the agents and propose an efficient means for extracting the distributed equilibrium strategies in common environments.
Probabilistic Self-Stabilization and Biased Random Walks on Dynamic Graphs

A distributed system is said to be probabilistic self-stabilizing, if it eventually converges to a legitimate computation with probability 1, starting from any global configuration. Like a self-stabilizing system, a probabilistic self-stabilizing system tolerates any number of transient failures and recovers a legitimate computation, but only probabilistically, unlike a self-stabilizing system, which recovers it deterministically even in the worst case. However, a self-stabilizing algorithm is in general difficult to design and even impossible for some problems. A probabilistic self-stabilizing, on the other hand, is easier to design. To see this, we discuss how a probabilistic self-stabilizing system is constructible from a given weak stabilizing system, which can recover a legitimate computation only in the best case. An execution of a probabilistic self-stabilizing system can be modeled by a random walk on a graph, and its performance can be evaluated in terms of some quantities, e.g., the hitting and the cover times, of the corresponding random walk. The hitting and the cover times of random walks have been studied extensively, but most of them consider standard (i.e., unbiased) random walks on static graphs. We discuss how to design biased random walks whose hitting and cover times are faster than standard random walks, to improve the performance of probabilistic self-stabilizing system. We also discuss random walks on dynamic graphs to analyze a probabilistic self-stabilizing system such that its communication network topology frequently changes.
A discrete model of thin shells

We present a discrete model for the behavior of thin flexible structures, such as hats, leaves, and aluminum cans, which are characterized by a curved undeformed configuration. Previously such models required complex continuum mechanics formulations and correspondingly complex algorithms. We show that a simple shell model can be derived geometrically for triangle meshes and implemented quickly by modifying a standard cloth simulator. Our technique convincingly simulates a variety of curved objects with materials ranging from paper to metal, as we demonstrate with several examples including a comparison of a real and simulated falling hat.This chapter is based on the paper by Grinspun, Hirani, Desbrun, and Schröder which appeared in the Proceedings of the Symposium for Computer Animation 2003 [Grinspun et al. 2003].
Dysregulated cellular functions and cell stress pathways provide critical cues for activating and targeting natural killer cells to transformed and infected cells

Natural killer (NK) cells recognize and kill cancer cells and infected cells by engaging cell surface ligands that are induced preferentially or exclusively on these cells. These ligands are recognized by activating receptors on NK cells, such as NKG2D. In addition to activation by cell surface ligands, the acquisition of optimal effector activity by NK cells is driven in vivo by cytokines and other signals. This review addresses a developing theme in NK cell biology: that NK‐activating ligands on cells, and the provision of cytokines and other signals that drive high effector function in NK cells, are driven by abnormalities that arise from transformation or the infected state. The pathways include genomic damage, which causes self DNA to be exposed in the cytosol of affected cells, where it activates the DNA sensor cGAS. The resulting signaling induces NKG2D ligands and also mobilizes NK cell activation. Other key pathways that regulate NKG2D ligands include PI‐3 kinase activation, histone acetylation, and the integrated stress response. This review summarizes the roles of these pathways and their relevance in both viral infections and cancer.
SIAR: splitting-graph-based interactive analog router

As analog and mixed-signal (AMS) circuitry gains increasing portions in modern SoCs, automotive analog routing is becoming more and more important. This paper presents a fast real-time interactive analog router called SIAR based on a splitting graph. A key feature is that SIAR allows real-time interactions between the router and the designer. The designer can try different guiding points by moving the cursor in the user window and the router will show the corresponding routing solutions in real-time for the designer to select the most satisfactory one. To enable real-time interactions, we present a new splitting graph to represent the routing area, which greatly enhances the routing efficiency. Different design rules such as variable wire and via width/spacing are supported by the router. Moreover, SIAR supports different routing modes such as point-to-point, point-to-module and module-to-module. Experimental results show that SIAR obtains promising routing efficiency with upto 28.6x speedup and better routing solutions compared with the commercial router Laker as well as upto 108x speedup compared with a modified implication-graph-based gridless routing approach [13].
Insect-Induced Conifer Defense. White Pine Weevil and Methyl Jasmonate Induce Traumatic Resinosis, de Novo Formed Volatile Emissions, and Accumulation of Terpenoid Synthase and Putative Octadecanoid Pathway Transcripts in Sitka Spruce1[w]

Stem-boring insects and methyl jasmonate (MeJA) are thought to induce similar complex chemical and anatomical defenses in conifers. To compare insect- and MeJA-induced terpenoid responses, we analyzed traumatic oleoresin mixtures, emissions of terpenoid volatiles, and expression of terpenoid synthase (TPS) genes in Sitka spruce (Picea sitchensis) following attack by white pine weevils (Pissodes strobi) or application of MeJA. Both insects and MeJA caused traumatic resin accumulation in stems, with more accumulation induced by the weevils. Weevil-induced terpenoid emission profiles were also more complex than emissions induced by MeJA. Weevil feeding caused a rapid release of a blend of monoterpene olefins, presumably by passive evaporation of resin compounds from stem feeding sites. These compounds were not found in MeJA-induced emissions. Both weevils and MeJA caused delayed, diurnal emissions of (−)-linalool, indicating induced de novo biosynthesis of this compound. TPS transcripts strongly increased in stems upon insect attack or MeJA treatment. Time courses and intensity of induced TPS transcripts were different for monoterpene synthases, sesquiterpene synthases, and diterpene synthases. Increased levels of weevil- and MeJA-induced TPS transcripts accompanied major changes in terpenoid accumulation in stems. Induced TPS expression profiles in needles were less complex than those in stems and matched induced de novo emissions of (−)-linalool. Overall, weevils and MeJA induced similar, but not identical, terpenoid defense responses in Sitka spruce. Findings of insect- and MeJA-induced accumulation of allene oxide synthase-like and allene oxide cyclase-like transcripts are discussed in the context of traumatic resinosis and induced volatile emissions in this gymnosperm system.
A Gene Trap Strategy for Identifying the Gene Expressed in the Embryonic Nervous System

Abstract An efficient gene trap strategy was devised for identifying the genes that are expressed in the mouse developing nervous system. Mouse embryonic stem (ES) cell lines that carried independent integrations of a gene trap vector, pSneolNlacZA, were allowed to differentiate in a suspension culture system. To select cells containing neurons, astrocytes or neuronglia precursors, cell lines were immunohistochemically examined with antibodies against neuron-specific proteins (neurofilament protein 150 kD and microtubule associated protein 2), glial fibrillary acidic protein or nestin. Three cell clones (GT3-8, 11 and 12) were immunoreactive to either of the antibodies employed and at the same time positive for &bgr;-galactosidase activity. When chimeric embryos were generated by the use of the above 3 cell lines, some cells in their nervous system showed X-gal staining. Thus the major advantage of the present gene trap method lies in its prescreening step of manipulated ES cells prior to generation of chimeric animals. This method holds promise as a useful tool for investigating the genes involved in the development of the nervous system.
Multiobjective optimized subchannel allocation for wireless OFDM systems

In this paper, we investigate the problem of dynamic subchannel assignments in the downlink of OFDM (Orthogonal Frequency Division Multiplexing) systems. The Kuhn-Munkres algorithm can provide the maximum weighted bipartite matching for assignment problems. In this paper, we formulate the multiobjective optimization (MO) problem in bipartite matching, and propose a modified bipartite matching algorithm(MBM) for assignments with MO requirements. This algorithm can be used to solve the weighted bipartite matching problem with multiobjective optimization. We illustrate the application of MBM to subchannel assignments in wireless OFDM systems. The simulation results show that MBM enjoys low computational complexity and maximizes the system capacity, while keeping the fairness among mobile users.
Direct detection of Vibrio cholerae in stool samples

A direct method to detect Vibrio cholerae in stool samples was developed by using a PCR procedure that did not require a DNA purification step. Dilution (1/100) of stool samples prevented inhibition of the reaction by contaminants, and two consecutive PCRs, the second one with a nested primer, achieved the desired sensitivity. Comparison of the results obtained from stool swab samples processed by the two-step PCR and by an enzyme-linked immunosorbent assay using GM1 as the capture molecule showed that the former is more sensitive and gave positive results even when V. cholerae was not culturable or dead.
Integration of CNTs Thin Film for Sensing and Actuating Micro Structures

This paper reports the top-down fabrication of CNTs thin film on MEMS structure to develop sensing and actuating micro structures. In particular, this paper review the integration of CNTs film in application of silicon micromirror based on angular vertical comb actuator, development of microstructures with piezoresistive effect and Seebeck effect.
Online Submission ID : 1199 Gremlin : An Interactive Visualization Model for Analyzing Genomic Rearrangements

In this work we present, apply, and evaluate a novel, interactive visualization model for comparative analysis of structural variants and rearrangements in human genomes, with emphasis on data integration and uncertainty visualization. To support both global trend analysis and local feature detection, this model enables explorations continuously scaled from the highest-level, complete genome perspective, down to the lowest-level, nucleotide base-pair view, while preserving global context at all times. We have implemented these techniques in Gremlin, a genomic rearrangement explorer with multi-scale, linked interactions, which we apply to four human cancer genome data sets for evaluation. Using an insight-based evaluation methodology, we compare Gremlin to Circos, the state-of-the-art in genomic rearrangement visualization, through a small user study with computational biologists working in rearrangement analysis. Results from user study evaluations demonstrate that this visualization model enables more total insights, more insights per minute, and more complex insights than the current state-of-the-art for visual analysis and exploration of genome rearrangements.
Interdisciplinary intervention decreases cognitive impairment for older Taiwanese with hip fracture: 2‐year follow‐up

Few studies describe the trajectories of cognitive function for hip‐fracture patients following hospital discharge and the treatment effects of interdisciplinary intervention on cognitive outcomes. The purpose of this study was to explore the 2‐year postoperative trajectory for cognitive function of older hip‐fracture patients and cognitive effects of an interdisciplinary intervention.
Probability density functions for analyzing multi-amplitude constellations in Rayleigh and Ricean channels

This paper derives probability density functions (PDFs) to describe the behavior of data demodulated with imperfect channel estimation. The PDFs apply to cases of flat Rayleigh-fading, multiple-diversity reception Rayleigh-fading, and flat Ricean-fading. These PDFs can be used to determine analytically both the symbol error rate and bit error rate for multi-amplitude constellations with in-phase and quadrature components, thus avoiding the need for extensive computer simulation.
Evaluation of invasive aspergillosis risk of immunocompromised patients alternatively hospitalized in hematology intensive care unit and at home.

UNLABELLED Contrary to hospital exposure, little is known about the indoor fungal exposure of hematology patients at home. The aim of our study was to investigate the mold exposure of hematology patients both at home and at hospital to assess their invasive aspergillosis (IA) risk. Fungal exposure was assessed by quantifying opportunistic molds at hospital during hospitalization and in homes of 53 hematology patients. IA was diagnosed in 13 of 53 patients and invasive fungal infection (IFI) in one patient. In hospital, no opportunistic species, or low levels of opportunistic species, were found in 98% of weekly controls. Only 2% of hematology intensive care unit (ICU) controls showed a high level of Aspergillus fumigatus spores in corridor air. Five patients IA were hospitalized during these periods. Seven dwellings of 53 (5/14 dwellings of patients with IA/IFI and 2/39 dwellings of non-IA patients) had a percentage of A. fumigatus and Aspergillus flavus to total mold (significant predictor variable of IA/IFI in our study, general linear model, P-value = 0.02) as high as 15%. Maintaining a 'zero Aspergillus' goal at hospital is essential, and establishing specific and individually opportunistic mold monitoring at home could help to further reduce the IA risk through continuous surveillance. PRACTICAL IMPLICATIONS This study emphasizes the fact that preventive measures should not be aimed only at the hospital setting: among patients diagnosed with invasive aspergillosis/invasive fungal infection (IA/IFI), 5 of 14 (36%) were exposed to opportunistic fungal species at home exclusively. Moreover, four of these five patients were living in homes having the highest percentage of Aspergillus fumigatus and Aspergillus flavus (>15%), one of which had 48% of A. fumigatus. Therefore, our work supports the need for a counselor to carry out an environmental survey in patients’ homes.
Arrangements of circles on a sphere : Algorithms and applications to molecular models represented by a union of balls. (Arrangements de cercles sur une sphère: Algorithmes et Applications aux modèles moléculaires representés par une union de boules)

Since the early work of Richard et al., geometric constructions have been paramount for the description of macromolecules and macro-molecular assemblies. In particular, Voronoi and related constructions have been used to describe the packing properties of atoms, to compute molecular surfaces, to find cavities. This thesis falls in this realm, and after a brief introduction to protein structure, makes four contributions. First, using the sweep line paradigm of Bentley and Ottmann, we present the first effective algorithm able to construct the exact arrangement of circles on a sphere. Moreover, assuming the circles stem from the intersection between spheres, we present a strategy to report the covering list of a face of the arrangement---that is the list of spheres covering it. Along the way, we ascertain the fact that exactness of the arrangement can be achieved with a small computational overhead. Second, we develop the algebraic and geometric primitives required by the sweep algorithm, so as to make it generic and robust. These primitives are integrated in a broader context, namely the CGAL 3D Spherical Kernel. Third, we use the aforementioned machinery to tackle a computational structural biology problem, namely the selection of diverse conformations from a large redundant set. We propose to solve this selection problem by computing representatives maximizing the surface area or the volume of the selection. From a geometric standpoint, these questions can be handled resorting to arrangements of circles and spheres. The validation is carried out along two lines. On the geometric side, we show that our selections match the molecular surface area of selections output by standard strategies but using a smaller number of conformers by one and two orders of magnitude. On the docking side, we show that our selections can significantly improve the results obtained for a flexible-loop docking algorithm. Finally, we discuss the implementation issues and the design choices, in the context of the best practices underlying the development of CGAL.