Miracle-dz/UniFAR-FTUs huggingface dataset:
Time series forecasting based on deep extreme learning machine

Multi-layer Artificial Neural Networks (ANN) has caught widespread attention as a new method for time series forecasting due to the ability of approximating any nonlinear function. In this paper, a new local time series prediction model is established with the nearest neighbor domain theory, in which the hybrid Euclidean distance is used as the similarity measurement between two sets of time series. In order to improve the efficiency, prediction performance, as well as the ability of real-time updating of the model, in this paper, the recombination samples of the model is derived by Deep Extreme Learning Machine (DELM). The experiments show that local prediction model gets accurate results in one-step and multi-step forecasting, and the model has good generalization performance through the test on the five data sets selected from Time Series Database Library (TSDL).
Calculation of the dynamic air flow resistivity of fiber materials

The acoustic attenuation of acoustic fiber materials is mainly determined by the dynamic resistivity to an oscillating air flow. The dynamic resistance is calculated for a model with geometry close to the geometry of real fiber material. The model consists of parallel cylinders placed randomly. Two cases are treated: flow perpendicular to the cylinder axes, and flow parallel to the axes. In each case two new approximate procedures were used. In the first procedure, one solves the equation of flow in a Voronoi cell around the fiber, and averages over the distribution of the Voronoi cells. The second procedure is an extension to oscillating air flow of the Brinkman self-consistent procedure for dc flow. The procedures are valid for volume concentration of cylinders less than 0.1. The calculations show that for the density of fibers of interest for acoustic fiber materials the simple self-consistent procedure gives the same results as the more complicated procedure based on average over Voronoi cells. Graphs of the dynamic resistivity versus frequency are given for fiber densities and diameters typical for acoustic fiber materials.
Differential traffic of proximal tubule Na+ transporters during hypertension or PTH: NHE3 to base of microvilli vs. NaPi2 to endosomes.

We previously reported that Na(+)/H(+) exchanger type 3 (NHE3) and NaPi2 are acutely retracted from the proximal tubule (PT) microvilli (MV) during acute hypertension [high blood pressure (BP)] or parathyroid hormone (PTH) treatment. By subcellular membrane fractionation, NHE3 and NaPi2 show indistinguishable redistribution patterns out of light-density into heavy-density membranes in response to either treatment consistent with a retraction from the apical MV to the intermicrovillar cleft region. This study aimed to examine the redistribution of PT NHE3 vs. NaPi2 by confocal and electron microscopy during high BP and during PTH treatment to determine whether their respective destinations overlap or are distinct. High-BP protocol: systolic BP was increased 50-60 mmHg by increasing peripheral resistance for 20 min; PTH protocol: rats were infused with 6.6 microg/kg iv of PTH followed by 0.1 microg.kg(-1). min(-1) infusion for 1 h. For light microscopy, rats were infused with 25 mg of horseradish peroxidase (HRP) 10 min before kidney fixation. Kidney slices were dual labeled with either NHE3 or NaPi2 and either clathrin-coated vesicle adaptor protein AP2 or endosome marker HRP. The results demonstrate retraction of NHE3 from the MV to the base of MV during either high-BP or PTH treatment: NHE3 staining did not retract below the AP2-stained domain or to HRP-labeled endosomes in either model. In comparison, NaPi2 was retracted from MV to below the AP2-stained region in both models, a little colocalizing with HRP staining. At the electron microscopic level with immunogold labeling, during high BP NHE3 was concentrated in a distinct domain in the base of the MV while NaPi2 moved to endosomes. The results demonstrate that there are divergent routes of retraction of PT NHE3 and NaPi2 from the MV during acute hypertension or PTH treatment: NHE3 is not internalized but remains at the base of the MV while NaPi2 is internalized.
Resource management for continuous multimedia database applications

The uniqueness of continuous multimedia database applications lies in the fact that they require system support steady flow of media access data. In this paper we address the problem of system resource management for such applications. We introduce a session-based scheduling paradigm that, unlike traditional task scheduling, enables scheduling of all processing entities (threads, I/O processes, and buffers) across multiple system resources for guarantee of steady mediaflow. Under this paradigm, we develop an approach to on-line generation of session resource requirements based on resource allocation tradeoffs. Further, we develop a multidimensional "bin-packing" approach to allocation and scheduling of multiple resources for concurrent sessions. The goal is to minimize resource overheads and maximize the number of concurrent sessions while meeting session timing constraints and resource capacity constraints. <<ETX>>
Inducible Hsp70 as target of anticancer immunotherapy: Identification of HLA‐A*0201‐restricted epitopes

The design of a broad application tumor vaccine requires the identification of tumor antigens expressed in a majority of tumors of various origins. We questioned whether the major stress‐inducible heat shock protein Hsp70 (also known as Hsp72), a protein frequently overexpressed in human tumors of various histological origins, but not in most physiological normal tissues, constitutes a tumor antigen. We selected the p391 and p393 peptides from the sequence of the human inducible Hsp70 that had a high affinity for HLA‐A*0201. These peptides were able to trigger a CTL response in vivo in HLA‐A*0201‐transgenic HHD mice and in vitro in HLA‐A*0201+ healthy donors. p391‐ and p393‐specific human and murine CTL recognized human tumor cells overexpressing Hsp70 in a HLA‐A*0201‐restricted manner. Tetramer analysis of TILs showed that these Hsp70 epitopes are targets of an immune response in many HLA‐A*0201+ breast cancer patients. Hsp70 is a tumor antigen and the Hsp70‐derived peptides p391 and p393 could be used to raise a cytotoxic response against tumors of various origins. © 2003 Wiley‐Liss, Inc.
Lattice and trellis quantization with lattice- and trellis-bounded codebooks - High-rate theory for memoryless sources

High-rate lattice and trellis quantizers for nonuniform sources are introduced and analyzed. The performance of these quantizers is determined by two separable quantities, the granular gain and the boundary gain, which are determined by the shapes of the granular cells and of the support region, respectively. The granular gain and boundary gain are the duals of shaping and coding gain in data transmission applications. Using this duality, it is shown for Gaussian sources that the ultimate achievable boundary gain with high-rate lattice-bounded lattice codebooks is the same as the ultimate gain that can be obtained from variable-rate entropy coding. It is observed that if lattice codebooks can achieve the ultimate granular gain of 0.255 b per dimension, then lattice-bounded lattice codebooks can approach the rate-distortion limit. The performance of lattice quantizers is compared to that of optimum vector quantizers. >
Virtual road side units for geo-routing in VANETs

Vehicular networking is the new key context to offload the cellular network of the great amount of contents produced on the move. In this paper, we focus on the exploitation of vehicle-to-vehicle communications to deliver part of the data produced on board to the road side units (RSUs) deployed in the scenario, avoiding, as much as possible, the adoption of the cellular network. Specifically, we propose a novel routing algorithm that is based on the greedy forwarding approach and uses virtual RSUs to overcome the problem of the local minima. The proposed algorithm allows data to be redirected through optimized directions with limited amount of added information. In addition, system optimization can be performed via software and the choice of the RSU positions becomes less critical. The effectiveness of the proposed algorithm is demonstrated through simulations performed using realistic vehicular traces in two European cities, showing that the proposed solution increases the amount of data transmitted through the vehicular networks.
A new estimator for vector velocity estimation [medical ultrasonics]

A new estimator for determining the two-dimensional velocity vector using a pulsed ultrasound field is derived. The estimator uses a transversely modulated ultrasound field for probing the moving medium under investigation. A modified autocorrelation approach is used in the velocity estimation. The new estimator automatically compensates for the axial velocity when determining the transverse velocity. The estimation is optimized by using a lag different from one in the estimation process, and noise artifacts are reduced by averaging RF samples. Further, compensation for the axial velocity can be introduced, and the velocity estimation is done at a fixed depth in tissue to reduce the influence of a spatial velocity spread. Examples for different velocity vectors and field conditions are shown using both simple and more complex field simulations. A relative accuracy of 10.1% is obtained for the transverse velocity estimates for a parabolic velocity profile for flow transverse to the ultrasound beam and a SNR of 20 dB using 20 pulse-echo lines. The overall bias in the estimates was -4.3%.
Effect of immunological castration on sexual and production characteristics in male cattle

Ten male Friesian calves were actively immunised against luteinising hormone releasing hormone and their production compared with 10 Friesian steer calves. Five of the immunised calves responded poorly (group 1); the other five responded well (group 2), resulting in high antibody titres, low serum testosterone levels, involuted testes, reduced libido and semen production, and docile behavior. The castration effect lasted approximately six months before reversion to near normal male status. This temporary immunocastration failed to affect seriously performance until slaughter, and liveweight gain was substantially better in this group than in the steers. Carcase traits were similar in groups 1 and 2, but the lean content in both was considerably greater than in the steer carcases.
CrystalNest at SemEval-2017 Task 4: Using Sarcasm Detection for Enhancing Sentiment Classification and Quantification

This paper describes a system developed for a shared sentiment analysis task and its subtasks organized by SemEval-2017. A key feature of our system is the embedded ability to detect sarcasm in order to enhance the performance of sentiment classification. We first constructed an affect-cognition-sociolinguistics sarcasm features model and trained a SVM-based classifier for detecting sarcastic expressions from general tweets. For sentiment prediction, we developed CrystalNest– a two-level cascade classification system using features combining sarcasm score derived from our sarcasm classifier, sentiment scores from Alchemy, NRC lexicon, n-grams, word embedding vectors, and part-of-speech features. We found that the sarcasm detection derived features consistently benefited key sentiment analysis evaluation metrics, in different degrees, across four subtasks A-D.
The effects of factor supply assumptions on intertemporal timber supply behavior. The cases of investable funds and land

Intertemporal timber supply models typically assume perfect capital markets and perfectly inelastic supplies of land. Using a dynamic model of U.S. timber and agriculture markets, we examine (i) borrowing limits or capital constraints, in which investment in forest management on nonindustrial private ownerships is restricted, and (ii) a nonzero elasticity of land supply. Results suggest that alternative treatments of supply conditions for these factors influence the flexibility of the simulated market system to adapt to changes over time and across policy scenarios. Supply restrictions limit adjustment options in management activities and force greater change in other endogenous elements such as price and consumption. Implications drawn from any policy analyses also differ with input supply assumptions. Policy impacts were found to be largely transitory in the cases without investment limits and essentially permanent when limits exist. Recognizing a price-sensitive land supply, at least as this process is.
Laparoscopic pyeloplasty: the first decade

ports introduced to enable dissection and identification of the PUJ. The technical principles and goals are similar to those of open surgery. Depending on the type of procedure the PUJ is either incised or dismembered, and reductive pyeloplasty performed if indicated. The ureteric JJ stent is typically inserted retrogradely before (the authors’ preference being 4.7 F, 26 cm) or during surgery. A drain is inserted to lie adjacent to the completed repair and a Foley catheter is left in the bladder.
Adolescents américains et français : obésité, troubles du comportement alimentaire, attitudes et habitudes alimentaires

Cette these en doctorat presente les resultats d’une etude comparative sur le theme de l’alimentation et des caracteristiques ponderales des adolescents francais et americains. Nous avons etudie notamment les questions des frequences respectives de l’obesite (OB), des attitudes et habitudes alimentaires dites « normales » ou dite de l’« alimentation journaliere » (HAAJ) et des troubles du comportement alimentaire (TCA) comme l’anorexie mentale (AN) et la boulimie (BN) dans deux echantillons d’adolescents francais (N=1031) et americains (N=1573). Les principaux objectifs etaient de comparer ces echantillons pour leurs poids, leurs HAAJ, leur insatisfaction corporelle (liee avec l’OB et les TCA), les symptomes de TCA observes, et les « diagnostics » de TCA poses, afin de determiner s’il existe des differences significatives entre ces deux cultures. Apres la creation d’un outil d’evaluation des HAAJ, une serie de questionnaires a ete administree dans plusieurs lycees et colleges en France et aux Etats Unis. L’enquete avait pour hypotheses: 1. ) que les francais montrent un taux d’obesite et surpoids moindres par rapport aux americains; 2. ) que les francais montrent davantage de HAAJ dites « saines » 3. ) que des prevalences de TCA cliniques et sub-cliniques sont moindres pour le groupe des francais. Les resultats sur le statut ponderal soutiennent la premiere hypothese. Les resultats sur les HAAJ soutiennent globalement la deuxieme hypothese. En revanche la troisieme hypothese n’a pas ete confirmee.
Bovine papillomavirus type 1 3' early region transformation and plasmid maintenance functions

We examined bovine papillomavirus type 1 (BPV-1) DNAs mutated in the E2 open reading frame (ORF) to determine their ability (i) to transform C127 cells and (ii) to remain extrachromosomal in transfected cells. Results obtained with deletion mutants and insertion mutants containing a linker with translational termination codons in all possible reading frames indicated that an E2 ORF gene product(s) is necessary for efficient transformation, as well as viral plasmid replication and maintenance in the context of the full BPV-1 genome. Complementation assays in which mutant BPV-1 DNAs were transfected into cell lines expressing some viral functions from integrated BPV-1 cDNAs demonstrated that the E2 ORF product, when provided in trans, could allow BPV-1 E2 mutants to remain extrachromosomal. The E2 function could also augment transformation of some, but not all, BPV-1 E2 mutants, allowing identification of another region of BPV-1 involved in cellular transformation. It is likely that the role of the BPV-1 E2 product(s) in transformation and plasmid maintenance is indirect. A BPV-1 mutant altered in the E5 ORF is transformation defective and unable to replicate as a stable plasmid in C127 cells.
Transcriptional Activation and Increased mRNA Stability Contribute to Overexpression of CDR1 in Azole-Resistant Candida albicans

ABSTRACT Many azole-resistant (AR) clinical isolates of Candida albicans display increased expression of the drug transporters CDR1 and CDR2. In this study, we evaluate the molecular mechanisms that contribute to the maintenance of constitutively high CDR1 transcript levels in two matched pairs of azole-susceptible (AS) and AR clinical isolates of C. albicans. To address this, we use reporter constructs of GFP and lacZ fused either to the CDR1 promoter (PCDR1-GFP/lacZ; transcriptional fusion) or to the CDR1 open reading frame (PCDR1-CDR1-GFP/lacZ; translational fusion) integrated at the native CDR1 locus. It is observed that expression of the two reporter genes as a transcriptional fusion in the AR isolates is higher than that in matched AS isolates. However, the difference in the reporter activity between the AS and AR isolates is even greater for the translational fusions, indicating that the sequences within the CDR1 coding region also contribute to its increased expression in AR isolates. Further analysis of these observations by transcription run-on assays demonstrated a ∼5- to 7-fold difference in the transcription initiation rates for the AR isolates from those for their respective matched AS isolates. Measurement of mRNA stability showed that the half-life of CDR1 mRNA in the AR isolates was threefold higher than that in the corresponding AS isolates. Our results demonstrate that both increased CDR1 transcription and enhanced CDR1 mRNA stability contribute to the overexpression of CDR1 in AR C. albicans isolates.
Estimated GFR and circulating 24,25-dihydroxyvitamin D3 concentration: a participant-level analysis of 5 cohort studies and clinical trials.

BACKGROUND Decreased glomerular filtration rate (GFR) leads to reduced production of 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3 (25[OH]D3). Effects of low GFR on vitamin D catabolism are less well understood. We tested associations of estimated GFR (eGFR) with the circulating concentration of 24,25-dihydroxyvitamin D3 (24,25[OH]2D3), the most abundant product of 25(OH)D3 catabolism, across populations with a wide range of GFRs. STUDY DESIGN Cross-sectional study. SETTING & PARTICIPANTS 9,596 participants in 5 cohort studies and clinical trials: the Diabetes Control and Complications Trial (N=1,193), Multi-Ethnic Study of Atherosclerosis (N=6,470), Cardiovascular Health Study (N=932), Seattle Kidney Study (N=289), and Hemodialysis Study (N=712). PREDICTOR eGFR. OUTCOME Circulating 24,25(OH)2D3 concentration. MEASUREMENTS GFR was estimated from serum creatinine using the Chronic Kidney Disease Epidemiology Collaboration equation. Vitamin D metabolites were measured by mass spectrometry. RESULTS Circulating 24,25(OH)2D3 concentration was correlated with circulating 25(OH)D3 concentration (Pearson r range, 0.64-0.88). This correlation was weaker with lower eGFRs. Moreover, the increment in 24,25(OH)2D3 concentration associated with higher 25(OH)D3 concentration (slope) was lower with lower eGFRs: 2.06 (95% CI, 2.01-2.10), 1.77 (95% CI, 1.74-1.81), 1.55 (95% CI, 1.48-1.62), 1.17 (95% CI, 1.05-1.29), 0.92 (95% CI, 0.74-1.10), 0.61 (95% CI, 0.22-1.00), and 0.37 (95% CI, 0.35-0.39) ng/mL of 24,25(OH)2D3 per 10 ng/mL of 25(OH)D3 for eGFRs≥90, 60-89, 45-59, 30-44, 15-29, and <15 mL/min/1.73 m2 and end-stage renal disease treated with hemodialysis, respectively. As a result, at a 25(OH)D3 concentration of 20 ng/mL, mean 24,25(OH)2D3 concentrations were 2.92 (95% CI, 2.87-2.96), 2.68 (95% CI, 2.64-2.72), 2.35 (95% CI, 2.26-2.45), 1.92 (95% CI, 1.74-2.10), 1.69 (95% CI, 1.43-1.95), 1.14 (95% CI, 0.62-1.66), and 1.04 (95% CI,1.02-1.07) ng/mL for each category, respectively. This interaction was independent of other relevant clinical characteristics. Race, diabetes, urine albumin excretion, and circulating parathyroid hormone and fibroblast growth factor 23 concentrations more modestly modified the association of 24,25(OH)2D3 with 25(OH)D3. LIMITATIONS Lack of direct pharmacokinetic measurements of vitamin D catabolism. CONCLUSIONS Lower eGFR is associated strongly with reduced vitamin D catabolism, as measured by circulating 24,25(OH)2D3 concentration.
Isolation and purification of ent-pimara-8(14),15-diene from engineered Aspergillus nidulans by accelerated solvent extraction combined with HPLC

We recently engineered Aspergillus nidulans to produce a pimarane-type diterpene, ent-pimara-8(14),15-diene. Here, we describe methods for its isolation and purification from the engineered A. nidulans production strain and extend these findings with structural confirmation for the diterpene from this fungal source. The extraction protocol was optimized using accelerated solvent extraction (ASE) with three varying parameters: solvent composition, pressure, and temperature. This ASE method using 100% ethyl acetate at 90 °C with 12.07 MPa was more efficient and faster compared to ultrasonic-assisted extraction. Using both analytical and preparative C18 columns at isocratic elution of acetonitrile developed an HPLC separation; and, the diterpene was well separated within 28 min and 35 min, respectively. Also, TLC of the fungal culture extracts was performed with visualization using rhodamine. The reproduction and efficiency of the purification methods were evaluated by GC-MS; and, the structure of the compound was verified by NMR. The method enabled the isolation of this very lipophilic diterpene in pure form, allowing its testing in a number of bioactivity assays. Notably, we demonstrate for the first time the antioxidant activity for ent-pimara-8(14),15-diene using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.
Estimating joint angles from biological signals for multi-joint exoskeletons

Biological signals are used to control robotic exoskeletons. Our research group has developed a Brain-Machine Interface (BMI)-based Occupational Therapy Assist Suit (BOTAS), which can be controlled by both electroencephalography (EEG) and electromyography (EMG) signals. This paper presents a new method for estimating the joint angles of the arms and hands for the BOTAS from EMG signals using mathematical musculoskeletal models. In six able-bodied participants, the method succeeded in estimating the flexion/extension angles of the elbow, wrist, and metacarpophalangeal (MP) joint of the index finger. In a patient with an upper cervical spinal cord injury, the method succeeded in estimating the elbow angles. The participants could control the BOTAS empowered by the method. These results suggest that the method is potentially useful for controlling robotic exoskeletons in patients with paralyzed arms and fingers.