Miracle-dz/UniFAR-FTUs huggingface dataset:
Variability in interpretation of immunohistologic findings in lymphoproliferative disorders by hematopathologists. A comprehensive statistical analysis of interobserver performance

Eight hematopathologists independently reviewed 56 consecutive cases of benign and malignant lymphoproliferative disorders (LPD) to determine: (1) the degree of interobserver agreement on the interpretation of immunologic findings on fresh‐frozen sections alone and on that of the immunologic findings in conjunction with corresponding hematoxylin and eosin (H & E)‐stained histologic sections; (2) whether prior knowledge of morphologic characteristics influences the interpretation of immunohistologic sections; (3) whether immunologic phenotype could be predicted reliably based solely on study of histologic sections; and (4) the significance of immunologic data as an aid in the interpretation of histologic sections. The study was carried out in three independent review sessions consisting of (1) review of immunohistologic sections only, (2) review of the same immunohistologic sections together with histologic sections, and (3) review of the histologic sections alone. A consensus diagnosis was defined as agreement of five or more pathologists on the final diagnosis and identification of the immunophenotype. When the authors compared the total number of major disagreements in the first review session with those in the second, the accuracy of the determination of immunophenotype in the second session was clearly superior (P < 0.05). Similarly, the total number of major disagreements in the second review session was significantly lower than that in the third review session (P < 0.001). When histologic diagnoses in the second session were compared with those in the third session, it became apparent that the immunologic data helped the pathologist to correct major misinterpretations in 14 cases (25%). This study is the first to demonstrate quantitatively that (1) knowledge of morphologic features influences and greatly enhances the accuracy of the interpretation of immunologic findings, (2) the immunophenotype of LPD cannot be predicted based on morphologic findings alone, and (3) immunologic findings improve the accuracy of interpretation of histologic findings in situations in which a diagnosis cannot be made from morphologic features only.
Student differences in regulation strategies and their use of learning resources: implications for educational design

The majority of the learning analytics research focuses on the prediction of course performance and modeling student behaviors with a focus on identifying students who are at risk of failing the course. Learning analytics should have a stronger focus on improving the quality of learning for all students, not only identifying at risk students. In order to do so, we need to understand what successful patterns look like when reflected in data and subsequently adjust the course design to avoid unsuccessful patterns and facilitate successful patterns. However, when establishing these successful patterns, it is important to account for individual differences among students since previous research has shown that not all students engage with learning resources to the same extent. Regulation strategies seem to play an important role in explaining the different usage patterns students' display when using digital learning recourses. When learning analytics research incorporates contextualized data about student regulation strategies we are able to differentiate between students at a more granular level. The current study examined if regulation strategies could account for differences in the use of various learning resources. It examines how students regulated their learning process and subsequently used the different learning resources throughout the course and established how this use contributes to course performance. The results show that students with different regulation strategies use the learning resources to the same extent. However, the use of learning resources influences course performance differently for different groups of students. This paper recognizes the importance of contextualization of learning data resources with a broader set of indicators to understand the learning process. With our focus on differences between students, we strive for a shift within learning analytics from identifying at risk students towards a contribution of learning analytics in the educational design process and enhance the quality of learning; for all students.
Improvement of Fatty Acid Profile and Studio of Rheological and Technological Characteristics in Breads Supplemented with Flaxseed, Soybean, and Wheat Bran Flours

Functional breads constitute an interesting alternative as vehicle of new essential fatty acids sources. The aim of this study was to improve the fatty acids (FA) profile of bakery products, producing breads with low saturated fatty acid (SFA) content and with high polyunsaturated fatty acid (PUFA) content, through partial substitution of wheat flour by other ingredients (soy flour, flax flour, and wheat bran) and to analyze the effect of this change on the technological, rheological, and sensorial characteristics of breads. Flaxseed flour (FF), soybeans flour (SF), or wheat bran (WB) was used to replace 50, 100, and 150 g kg−1 of wheat flour (WF) in breads. FF or SF produced a decrease in monounsaturated and SFA and an increase of PUFA in these breads. Furthermore, breads replaced with FF presented considerable increase in the content of n3 FA, while, SF or WB contributed to rise of linoleic and oleic FA, respectively. The substitution percentage increase of FF, SF, or WB to formulation produced changes in the colour, rheological, textural, and technological characteristics of breads. This replacement resulted in improved lipid profile, being breads with 50 g kg−1 SF, the better acceptance, baking features, and enhanced fatty acid profile.
Design of RF CMOS low noise amplifiers using a current based MOSFET model

This paper presents a design methodology for RF CMOS low noise amplifiers (LNA). This methodology uses a current-based MOSFET model, which allows a detailed analysis of an LNA for all MOSFET's inversion regions. Design equations, including the induced gate noise in MOS devices are also presented and a design example with simulation results is shown.
Clinical Characteristics of Dialysis Related Sclerosing Encapsulating Peritonitis: Multi-center Experience in Korea

Sclerosing encapsulating peritonitis (SEP) is a rare but serious complication in patients with continuous ambulatory peritoneal dialysis (CAPD), and is characterized by a progressive, intra-abdominal, inflammatory process resulting in the formation of sheets of new fibrous tissue, which cover, bind, and constrict the viscera, thereby compromising the motility of the bowel. No satisfactory estimate is available on the comparative incidence of dialysis related SEP and the pathogenesis of SEP still remains uncertain. Although recent therapeutic approaches have reported varying degrees of success, an efficient measure to detect, at an early stage, patients at risk for SEP would be beneficial and a standardized treatment regimen to prevent the illness is urgently needed. This study aimed to evaluate the clinical features of SEP and to identify the possible risk factors for the development of SEP in CAPD patients. We retrospectively reviewed by questionnaire SEP cases among CAPD patients from 7 university hospital dialysis centers in Korea, including Yonsei University, Ajou University, Catholic University, Inha University, Kyungpook University, Seoul National University and Soonchunhyang University, from January 1981 to December 2002. Out of a total of 4,290 CAPD patients in these centers, 34 cases developed SEP with an overall prevalence of 0.79%. The male to female ratio was 17:17. The median age of these patients was 44.5 years (range 19 - 66). The median duration of CAPD before SEP was 64 months (9 - 144) and 68% of patients (23/34) had been on CAPD for more than 4 years. Peritonitis (including two fungal cases) was the main cause of catheter removal in SEP (27 cases, 79%). Seventy-five percent of the cases (15/20) were administered β-blocker for a mean duration of 85 months (26 - 130). Among 10 cases with available peritoneal equilibration test (PET) data, 8 showed high transporter characteristics, and the remaining 2 were high average. Eighteen cases were diagnosed by clinical and radiologic methods, and 16 were surgically diagnosed. Eleven cases were surgically treated and the others were treated conservatively with intermittent total parenteral nutrition (TPN). The overall mortality rate was 24%. SEP is a serious, life threatening complication of CAPD. Most cases had a PD duration of more than 4 years, a history of severe peritonitis, and high transporter characteristics in PET. Therefore, to reduce the incidence of SEP, careful monitoring and treatment, including early catheter removal in patients with severe peritonitis, should be considered for long-term CAPD patients with the above characteristics.
Clinical effects of combined bilateral arm training with functional electrical stimulation in patients with stroke

Cerebral vascular disease (or stroke) is the main cause of disabilities in adults. Upper-limb dysfunction after stroke usually exists, leading to severe limits of motor capabilities as well as daily activities. Therefore, effective treatment interventions for upper-limb rehabilitation after stroke are needed. Based on the neurophysiological evidence and clinical measures, combined bilateral arm training (BAT) with functional electric stimulation (FES) could improve hand function in stroke patients. In this study, we attempt to combine BAT with FES applying to the post-stroke paretic arm. A linear guide platform with FES feedback control was developed to execute the training of bilateral reaching movements. 35 stroke subjects were recruited and divided into two groups (BAT with FES and BAT alone). 23 participants completed this experiment with 3-week intervention. According to our preliminary results, a favorable trend toward improvement in experimental group (BAT with FES) existed after treatment and at follow-up. Further analysis would be conducted to investigate the kinematic change on motor performance. Moreover, various treatment doses as well as more functional approaches would also be considered for better effects of upper limb rehabilitation after stroke.
Detailed spatio-temporal reconstruction of eyelids

In recent years we have seen numerous improvements on 3D scanning and tracking of human faces, greatly advancing the creation of digital doubles for film and video games. However, despite the high-resolution quality of the reconstruction approaches available, current methods are unable to capture one of the most important regions of the face - the eye region. In this work we present the first method for detailed spatio-temporal reconstruction of eyelids. Tracking and reconstructing eyelids is extremely challenging, as this region exhibits very complex and unique skin deformation where skin is folded under while opening the eye. Furthermore, eyelids are often only partially visible and obstructed due to self-occlusion and eyelashes. Our approach is to combine a geometric deformation model with image data, leveraging multi-view stereo, optical flow, contour tracking and wrinkle detection from local skin appearance. Our deformation model serves as a prior that enables reconstruction of eyelids even under strong self-occlusions caused by rolling and folding skin as the eye opens and closes. The output is a person-specific, time-varying eyelid reconstruction with anatomically plausible deformations. Our high-resolution detailed eyelids couple naturally with current facial performance capture approaches. As a result, our method can largely increase the fidelity of facial capture and the creation of digital doubles.
Fast inverse tone mapping with Reinhard's global operator

This paper proposes a novel inverse TMO, which enables to generate HDR images from LDR ones, not only without using any specific parameters but also at low computing costs. Furthermore, the inverse TMO has a new characteristic when an LDR image is mapped from an HDR one by Reinhard's global operator. In the case, the HDR image reconstructed by the proposed method without parameters can be remapped into the same image as that remapped from an HDR one reconstructed with parameters. Experimental results show that the proposed inverse tone mapping (TM) operation can be carried out, while keeping better structural similarity and lower computing cost than conventional methods.
An efficient and accurate hierarchical ICIA fitting method for 3D Morphable Models

We propose the efficient and accurate hierarchical ICIA fitting method for 3D Morphable Models (3DMMs). The conventional ICIA fitting method for 3DMMs requires a long computation time because the 3D face model contains a large number of vertices and it also requires to compute the Hessian matrix using the visible vertices every iteration. For the efficient fitting, we use the hierarchical fitting that use a set of multi-resolution 3D face model and the Gaussian image pyramid. For more accurate fitting, we use a two-stage parameter update that only update the rigid and the texture parameters and then update all parameters after the initial convergence. We present several experiment results to prove that our proposed method shows better performance than previous works.
To what extent could we detect field defects? an empirical study of false negatives in static bug finding tools

Software defects can cause much loss. Static bug-finding tools are believed to help detect and remove defects. These tools are designed to find programming errors; but, do they in fact help prevent actual defects that occur in the field and reported by users? If these tools had been used, would they have detected these field defects, and generated warnings that would direct programmers to fix them? To answer these questions, we perform an empirical study that investigates the effectiveness of state-of-the-art static bug finding tools on hundreds of reported and fixed defects extracted from three open source programs: Lucene, Rhino, and AspectJ. Our study addresses the question: To what extent could field defects be found and detected by state-of-the-art static bug-finding tools? Different from past studies that are concerned with the numbers of false positives produced by such tools, we address an orthogonal issue on the numbers of false negatives. We find that although many field defects could be detected by static bug finding tools, a substantial proportion of defects could not be flagged. We also analyze the types of tool warnings that are more effective in finding field defects and characterize the types of missed defects.
Affective and Behavioral Responses to Robot-Initiated Social Touch: Toward Understanding the Opportunities and Limitations of Physical Contact in Human–Robot Interaction

Social touch forms an important aspect of the human non-verbal communication repertoire, but is often overlooked in human-robot interaction. In this study, we investigated whether robot-initiated touches can induce physiological, emotional, and behavioral responses similar to those reported for human touches. 39 Participants were invited to watch a scary movie together with a robot that spoke soothing words. In the Touch condition, these words were accompanied by a touch on the shoulder. We hypothesized that this touch – as compared with no touch – could (H1) attenuate physiological (heart rate (variability), skin conductance, cortisol, and respiration rate) and subjective stress responses that were caused by the movie. Moreover, we expected that a touch could (H2) decrease aversion towards the movie, (H3) increase positive perceptions of the robot (e.g., its appearance and one’s attitude towards it), and (H4) increase compliance to the robot’s request to make a monetary donation. Although the movie did increase arousal as intended, none of the hypotheses could be confirmed. Our findings suggest that merely simulating a human touching action with the robot’s limbs is insufficient to elicit physiological, emotional, and behavioral responses in this specific context and with this amount of participants. To inform future research on the opportunities and limitations of robot-initiated touch, we reflect on our methodology and identify dimensions that may play a role in physical human-robot interactions: e.g., the robot’s touching behavior, its appearance and behavior, the user’s personality, the body location where the touch is applied, and the (social) context of the interaction. Social touch can only become an integral and effective part of a robot’s non-verbal communication repertoire, when we better understand if, and under which boundary conditions such touches can elicit responses in humans.
Qualitative analysis of SBS modifier in asphalt pavements using field samples

Series of tests are implemented to analysis the related characteristics of common asphalt and unknown asphalt mainly using Fourier Transform Infrared (FTIR) and Dynamic Shear Rheometer (DSR) for chemical compositions and rheological properties of asphalt, respectively. In addition, a series of mechanical properties were performed on asphalt mixtures, including indirect tensile strength test and three point bending test at low temperature. Experimental results indicated that compared with common asphalt, the characteristic absorption peak of the unknown asphalt are appeared at 966cm-1and 699cm-1, which are accordant with the SBS modifier. The results of DSR indicated that the unknown asphalt’s complex modulus is higher and the phase angle is lower. The mechanical tests indicated that some properties of the unknown mixture samples are increased by 24.7%∼41.8% compared with common pavement sample, like the indirect tensile strength, the bending test at low temperature and indirect tensile resilient modulus. Comprehensive analysis indicates that SBS modifier is existed in the unknown asphalt pavement.
Targeted advertising for online social networks

Generating targeted advertisements for online social networks is a problem of growing interest. Monetizing activity in online social networks has been the topic of heated discussion lately. The undiscriminating tastes and spending power of a majority of its members makes this medium for self-expression and opinion sharing a very lucrative venue for advertising. The recent $240 million investment by Microsoft in Facebook clearly reaffirms the opportunity in targeted advertising for online social networks. Content-targeted advertisement programs such as Google AdSense and Yahoo Contextual Match work by automatically spotting keywords in web pages and displaying ads based on the keywords. The displayed ads are also refereed as Contextual Advertisements. These ads are generally represented by a URL along with a textual description that is also used to match the ad with the target page. This model works relatively well on the Web but its applicability to social networks is being met with some important challenges. User activity on venues such as forums, marketplaces and groups on social networking sites are excellent targets for monetization. We present an algorithm based on keyword clustering to generate targeted ads.
Prenatal environmental exposures that may influence β-cell function or insulin sensitivity in middle age

The associations between fetal environment and diabetes risk are likely mediated by the offspring’s diminished pancreatic β-cell function or reduced insulin sensitivity. Our ability to distinguish between these mechanisms is impeded by the lack of markers describing an individual’s gestational environment. Fingerprints, however, are permanently fixed in the first half of gestation, and increased values of a dermatoglyphic marker that contrasts fingerprint ridge counts between the thumbs and fifth fingers (Md15) have been linked to type 2 diabetes. Among 763 adults without known diabetes from the Dutch Hunger Winter Families Study, we tested the associations of Md15 with homeostatic assessment indices of β-cell function (HOMA-b) and insulin sensitivity (QUICKI). For either outcome index, linear regression models included terms for Md15 tertiles and for maternal history of diabetes as reported by each participant. All models were corrected for sibling pairs and adjusted for age, sex and famine exposures. Increased Md15 was associated with decreased HOMA-b (P = 0.03 for Md15 tertile 3 v. 1) but not with QUICKI. In contrast, maternal history of diabetes was associated with decreased QUICKI (P < 0.001) but not with HOMA-b. Birth weight (available for 520 participants) was positively associated with increased QUICKI (P = 0.04 for birth weight tertile 3 v. 1) but not with HOMA-b. Fingerprint Md15, maternal history of diabetes and birth weight may help to identify specific defects in the control of adult glucose metabolism. Research into the environment associated with Md15 variation may suggest prenatal strategies for optimizing β-cell function in adult life.
Authorship Attribution with Topic Drift Model

Authorship attribution is an active research direction due to its legal and financial importance. The goal is to identify the authorship of anonymous texts. In this paper, we propose a Topic Drift Model (TDM), monitoring the dynamicity of authors’ writing style and latent topics of interest. Our model is sensitive to the temporal information and the ordering of words, thus it extracts more information from texts.
Gender Differences and the Effect of Different Endocrine Situations on the NOS Expression Pattern in the Anterior Pituitary Gland

The presence of neuronal nitric oxide synthase (nNOS) in two populations of pituitary cells, gonadotrophs (LH) and folliculostellate (FS) cells, suggests that pituitary nitric oxide (NO) is involved in the control of hormone secretion. We have used single and double immunostaining and quantitative procedures to investigate possible gender-related differences in the nNOS expression pattern in the anterior pituitary lobe and its possible alterations in different endocrine situations. Our results reveal a sexual dimorphism in the pattern of nNOS expression. In males, nNOS is mainly found in FS cells, whereas only a few LH cells express nNOS. Conversely, in females, nNOS is mainly found in LH cells. After gonadectomy, paralleling an increase in LH cell size and serum luteinizing hormone (LH) levels, there is nNOS upregulation in LH cells and nNOS downregulation in FS cells. After testoterone replacement, LH cells become nNOS-immunonegative again. In lactating rats, LH cells overexpress nNOS, but LH cell size and serum LH levels are low. This suggests that, depending on its cellular source, pituitary NO can exert either an inhibitory or a stimulatory effect on hormone secretion. When released from FS cells, NO exerts a paracrine inhibitory effect, and when released from gonadotrophs it exerts an autocrine or paracrine stimulatory effect on LH or prolactin secretion, respectively.