Miracle-dz/UniFAR-FTUs huggingface dataset:
PATIENT-SPECIFIC AND SURGERY-SPECIFIC FACTORS THAT AFFECT RETURN TO SPORT AFTER ACL RECONSTRUCTION.

CONTEXT Anterior cruciate ligament (ACL) reconstruction is frequently performed to allow individuals to return to their pre-injury levels of sports participation, however, return to pre-injury level of sport is poor and re-injury rates are unacceptably high. Re-injury is likely associated with the timeframe and guidelines for return to sport (RTS). It is imperative for clinicians to recognize risk factors for re-injury and to ensure that modifiable risk factors are addressed prior to RTS. The purpose of this commentary is to summarize the current literature on the outcomes following return to sport after ACL reconstruction and to outline the biologic and patient-specific factors that should be considered when counseling an athlete on their progression through rehabilitation. EVIDENCE ACQUISITION A comprehensive literature search was performed to identify RTS criteria and RTS rates after ACL reconstruction with consideration paid to graft healing, anatomic reconstruction, and risk factors for re-injury and revision. Results were screened for relevant original research articles and review articles, from which results were summarized. STUDY DESIGN Clinical Review of the Literature. RESULTS Variable RTS rates are presented in the literature due to variable definitions of RTS ranging from a high threshold (return to competition) to low threshold (physician clearance for return to play). Re-injury and contralateral injury rates are greater than the risk for primary ACL injury, which may be related to insufficient RTS guidelines based on time from surgery, which do not allow for proper healing or resolution of post-operative impairments and elimination of risk factors associated with both primary and secondary ACL injuries. CONCLUSIONS RTS rates to pre-injury level of activity after ACLR are poor and the risk for graft injury or contralateral injury requiring an additional surgery is substantial. Resolving impairments while eliminating movement patterns associated with injury and allowing sufficient time for graft healing likely gives the athlete the best chance to RTS without further injury. Additional research is needed to identify objective imaging and functional testing criteria to improve clinical decision making for RTS after ACLR. LEVEL OF EVIDENCE Level 5.
Lexical Simplification with the Deep Structured Similarity Model

We explore the application of a Deep Structured Similarity Model (DSSM) to ranking in lexical simplification. Our results show that the DSSM can effectively capture fine-grained features to perform semantic matching when ranking substitution candidates, outperforming the state-of-the-art on two standard datasets used for the task.
Nanoscale electron transport measurements of immobilized cytochrome P450 proteins

Gold nanopillars, functionalized with an organic self-assembled monolayer, can be used to measure the electrical conductance properties of immobilized proteins without aggregation. Measurements of the conductance of nanopillars with cytochrome P450 2C9 (CYP2C9) proteins using conducting probe atomic force microscopy demonstrate that a correlation exists between the energy barrier height between hopping sites and CYP2C9 metabolic activity. Measurements performed as a function of tip force indicate that, when subjected to a large force, the protein is more stable in the presence of a substrate. This agrees with the hypothesis that substrate entry into the active site helps to stabilize the enzyme. The relative distance between hopping sites also increases with increasing force, possibly because protein functional groups responsible for electron transport (ETp) depend on the structure of the protein. The inhibitor sulfaphenazole, in addition to the previously studied aniline, increased the barrier height for electron transfer and thereby makes CYP2C9 reduction more difficult and inhibits metabolism. This suggests that P450 Type II binders may decrease the ease of ETp processes in the enzyme, in addition to occupying the active site.
catena-Poly[sodium-μ2-(N,N,N′,N′-tetramethylethane-1,2-diamine)-κ2 N:N′-sodium-bis[μ2-bis(trimethylsilyl)azanido-κ2 N:N]]

The title compound, [Na2(C6H18NSi2)2(C6H16N2)]n, was found to consist of dimeric [Na(NSiMe3)2] units with crystallographically imposed centrosymmetry based upon four-membered NaNNaN rings. The dimers are bridged by N,N,N′,N′-tetramethylethylenediamine ligands, which act in an unusual extended non-chelating coordination mode. This gives a one-dimensional coordination polymer that extends parallel to the a-axis direction.
Molecular Characterization and Serotyping of Listeria monocytogenes with a Focus on Food Safety and Disease Prevention

I.C. Morobe1,2,4, C.L. Obi1,3, M.A. Nyila2, M.I. Matsheka4 and B.A. Gashe4 1Walter Sisulu University, Nelson Mandela Drive, Mthatha, Eastern Cape, 2School of Agriculture and Life Sciences, Department of Life and Consumer Sciences, University of South Africa, Pretoria, 3Division of Academic Affairs and Research, Walter Sisulu University, Eastern Cape, 4Department of Biological Sciences, University of Botswana, Gaborone, 1,2,3South Africa 4Botswana
Genetic Recombination in Streptomyces bikiniensis var. zorbonensis

A genetic recombination system in Streptomyces bikiniensis var. zorbonensis is described. This strain produces a mixture of antibiotics including zorbamycin and zorbonomycin B and C. A genetic map has been constructed from data obtained from an analysis of haploid recombinants which shows linkage relationships of 17 marker loci. Determination of map location has been made for three different loci affecting antibiotic biosynthesis in this strain.
C2TP: a service model for cloud

The notion of cloud computing capability is gathering momentum rapidly. However, the governance and enterprise architecture to obtain repeatable, scalable and secure business outcomes from cloud computing is still greatly undefined. There is very little research explored to define a framework that not only considers financial motivations, but also business initiatives, IT governance structures, IT operational control structures and technical architecture requirements to evaluate the benefits regarding cloud investment. We are proposing a novel model to address this. This model can be leveraged by an organisation to evaluate the ‘tipping point’ where the organisation can make an informative decision to embrace cloud computing at the expense of on-premise hosting options. The authors refer to this model as cloud computing tipping point (C2TP) model. The model is a service centric framework created by mapping cloud computing attributes with industry best practices such as ValIT, COBIT and ITIL.
RhoA and Cytoskeletal Disruption Mediate Reduced Osteoblastogenesis and Enhanced Adipogenesis of Human Mesenchymal Stem Cells in Modeled Microgravity

Spaceflight, aging, and disuse lead to reduced BMD. This study shows that overexpression of constitutively active RhoA restores actin cytoskeletal arrangement, enhances the osteoblastic phenotype, and suppresses the adipocytic phenotype of human mesenchymal stem cells cultured in modeled microgravity.
Case report of interstitial nephritis induced by bevacizumab therapy for glioblastoma multiforme

Glioblastoma multiforme is an aggressive malignant brain tumor. The monoclonal antibody, bevacizumab, is active in recurrent disease via inhibition of angiogenesis. Proteinuria and renal thrombotic microangiopathy are known complications. We report a case of a patient developing acute renal failure with biopsy-proven interstitial nephritis while receiving bevacizumab for recurrent disease. The patient was otherwise well with a history of controlled hypertension. Renal function improved with discontinuation of bevacizumab and the administration of corticosteroid therapy.
A Survey on Multi-label Classification for Images

The area of an image multi-label classification is increase continuously in last few years, in machine learning and computer vision. Multi-label classification has attracted significant attention from researchers and has been applied to an image annotation. In multi-label classification, each instance is assigned to multiple classes; it is a common problem in data analysis. In this paper, represent general survey on the research work is going on in the field of multi-label classification. Finally, paper is concluded towards challenges in multi-label classification for images for future research
An Improved Approach of DWT and ANC Algorithm for Removal of ECG Artifacts 

The electrocardiogram is the recording of the electrical potential of heart beat. The analysis of ECG signal plays a vital role in the detection of cardiac abnormalities. The ECG signals are often contaminated by noise from diverse sources. Noises that commonly disturb the basic electrocardiogram are power line interference, baseline wander, electrode motion. These noises can be classified according to their frequency content. It is essential to remove these disturbances in ECG signal to improve accuracy and reliability. Different types of adaptive algorithms have been proposed to remove these noises. In adaptive filter technique the filter coefficients can be varied to track the dynamic variations of the signals. The algorithms are Least Mean Square (LMS), Normalized Least Mean Square (NLMS) and Sign-Sign Least Mean Square (SSLMS). The new model is arrived to remove various noises by combining Discrete Wavelet Transform (DWT) and Adaptive Noise Cancellation technique (ANC). The Wavelet is used to form approximate and detail coefficients. ECG signal is obtained from MIT-BIH arrhythmia database. Denoising of ECG is performed by combining DWT and ANC technique. Keywords— Adaptive Noise Cancellation (ANC), Discrete Wavelet Transform (DWT), Least Mean Square (LMS), Normalized Least Mean Square (NLMS), Sign Sign LMS (SSLMS), Electrocardiogram
Handwritten character recognition using gradient feature and quadratic classifier with multiple discrimination schemes

In the research of statistical approach for handwritten character recognition, directional element feature (DEF) and modified quadratic discriminant function (MQDF) have been extremely successful and widely used in practical applications. In this paper, we apply several state-of-the-art techniques of handwritten character recognition on this baseline system to improve the recognition accuracy. In feature extraction stage, gradient feature is extracted to replace DEF, which provides higher resolution on both magnitude and angle of the directional strokes in character image. In classification stage, the performance of MQDF classifier is enhanced by multiple discrimination schemes, including minimum classification error (MCE) training on the classifier parameters and modified distance representation for similar characters discrimination. All these techniques we use lead to improvement on the character recognition rate. The performance of the improved recognition system has been evaluated by both handwritten digit recognition and handwritten Chinese character recognition experiments, in which very promising results are achieved.
Issues and challenges of real-time flash storage

Existing studies on flash storage have mainly focused on high performance and reliability. A new quality metric, real-time performance, has recently been required from both data centers and mobile devices. For data centers, it should be able to provide an illusion that each virtualized runtime environment has a dedicated storage on top of a single shared storage. In mobile devices, multimedia applications such as camcorders require uniform response times from the storage to avoid frame skipping. This paper addresses issues and challenges in designing real-time flash storage. Our investigation leads us to conclude that it is important to make the storage analyzable in terms of request response times while exploiting the chip-level parallelism as much as possible.
Noise Properties of Low-Temperature-Grown Co-Doped ZnO Nanorods as Ultraviolet Photodetectors

The growth of vertically aligned cobalt-doped ZnO (Co-ZnO) nanorods on a glass substrate using a low-temperature hydrothermal method is reported. A Co-ZnO nanorod metal-semiconductor-metal ultraviolet photodetector (PD) was also fabricated. The ratio of UV-to-visible rejection of the fabricated PD was approximately 11700 when biased at 1 V with a sharp cutoff at 380 nm. With an incident light wavelength of 380 nm and an applied bias of 1 V, the measured responsivity of the PD was found to be 19.8 A/W. Furthermore, the dark noise equivalent power (NEP) and photo NEP of the fabricated Co-ZnO nanorod MSM PD were 1.3 × 10<sup>-13</sup> and 1.8 × 10<sup>-11</sup> W at the corresponding dark detectivities (D*) and photo D* of 1.1 × 10<sup>14</sup> and 7.3 × 10<sup>11</sup> cm · Hz <sup>0.5</sup> · W <sup>-1</sup>, respectively.
How Does HTLV-1 Undergo Oncogene-Dependent Replication Despite a Strong Immune Response?

In 1987, Mitsuaki Yoshida proposed the following model (Yoshida and Seiki, 1987): “. T-cells activated through the endogenous p40x would express viral antigens including the envelope glycoproteins which are exposed on the cell surface. These glycoproteins are targets of host immune surveillance, as is evidenced by the cytotoxic effects of anti-envelope antibodies or patient sera. Eventually all cells expressing the viral antigens, that is, all cells driven by the p40x would be rejected by the host. Only those cells that did not express the viral antigens would survive. Later, these antigen-negative infected cells would begin again to express viral antigens, including p40x, thus entering into the second cycle of cell propagation. These cycles would be repeated in so-called healthy virus carriers for 20 or 30 years or longer. ” Three decades later, accumulated experimental facts particularly on intermittent viral transcription and regulation by the host immune response appear to prove that Yoshida was right. This Hypothesis and Theory summarizes the evidences that support this paradigm.
Alcohol consumption and social inequality at the individual and country levels--results from an international study.

BACKGROUND International comparisons of social inequalities in alcohol use have not been extensively investigated. The purpose of this study was to examine the relationship of country-level characteristics and individual socio-economic status (SES) on individual alcohol consumption in 33 countries. METHODS Data on 101,525 men and women collected by cross-sectional surveys in 33 countries of the GENACIS study were used. Individual SES was measured by highest attained educational level. Alcohol use measures included drinking status and monthly risky single occasion drinking (RSOD). The relationship between individuals' education and drinking indicators was examined by meta-analysis. In a second step the individual level data and country data were combined and tested in multilevel models. As country level indicators we used the Purchasing Power Parity of the gross national income, the Gini coefficient and the Gender Gap Index. RESULTS For both genders and all countries higher individual SES was positively associated with drinking status. Also higher country level SES was associated with higher proportions of drinkers. Lower SES was associated with RSOD among men. Women of higher SES in low income countries were more often RSO drinkers than women of lower SES. The opposite was true in higher income countries. CONCLUSION For the most part, findings regarding SES and drinking in higher income countries were as expected. However, women of higher SES in low and middle income countries appear at higher risk of engaging in RSOD. This finding should be kept in mind when developing new policy and prevention initiatives.
Minimally cationic cell-permeable miniature proteins via alpha-helical arginine display.

Protein therapeutics are a blossoming industry, with revenues exceeding $51 billion in 2005 and a growth rate nearly three times that of the overall pharmaceutical industry. Although it has been known for decades that cationic polymers can transport molecular cargos across the plasma membrane, inefficient cellular delivery continues to impede the development of protein drugs. Our lab recently reported that small, folded proteins containing a minimal cationic motif embedded within a type II polyproline (PPII) helix efficiently cross the plasma membrane of eukaryotic cells. Here we demonstrate that an even smaller cationic motif can be embedded within the α-helix of a small, folded protein to generate molecules that penetrate cells significantly more efficiently than arginine-rich sequences or Tat. Our results suggest that the function of cell permeability can be encoded by judicious placement of as few as 2−3 additional arginine residues on a protein α-helix.
[Validity of a job stressors measurement scale in nursing staff: the nursing stress scale].

BACKGROUND The aim of this work was to determine the reliability and construct validity of a scale intended to measure job stressors to which hospital nursing staff may be exposed. SUBJECTS AND METHODS The nursing stress scale contains 34 stressors. The scale's trans-cultural adaptation was carried out by means of the translation-back translation method. Validation was conducted on a random sample of 201 health professionals in a public hospital in Valencia. The reliability of the scale was assessed after its readministration on a sub-sample of 30 nursing professionals, with a 15 day interval. The construct validity was obtained through the correlation of the scale with another two scales: The 28 item version of Goldberg's General Health Questionnaire and 7 dimensions of the Health questionnaire SF-36. RESULTS The scale in Spanish language contains 34 items after eliminating the first item from the original scale (N1: computer failure) and including a new item (E1: Frequent job interruptions). The distribution of scores obtained in the initial administration of the scale and fifteen days later do not differ statistically. The Cronbach's alfa coefficient is 0.92 for the total scale and in each of the sub-scales ranges between 0. 83 and 0.49. The correlation between the scale and the GHQ-28 items questionnaire is 0.34. For each one of the seven dimensions of the SF-36 questionnaire the correlations range between -0.21 and -0.31. CONCLUSION The nursing stress scale is a useful instrument for measuring possible stressors in this collective. It has high internal consistency and construct validity, as does the original American version, however reliability is moderate.
CERVICAL-DISC RESECTION. A FOLLOW-UP OF MYELOGRAPHIC AND SURGICAL PROCEDURE.

During the period 1958 to 1962, 102 patients with disabling and painful conditions involving the upper extremities and neck were subjected to diagnostic examination by clinical and roentgenographic methods. Practically all patients had received various forms of conservative treatment. The distribution of pain varied but paresthesias and numbness were almost always localized to the fingers. In the majority of patients it proved impossible to find evidence of neurological impairment; electromyograms were rarely helpful. Eighty per cent of patients were between forty and sixty years of age. The ratio of men to women was 3 to 1. Plain roentgenograms of the cervical spine showed degeneration of one or more discs in practically all patients, but since such changes are common in this age group this finding was of limited diagnostic value. Examination of the mobility in the cervical spine in some patients by cineroentgenography gave inconclusive results and could not be relied upon as a basis for diagnosis of the level of involvement. Cervical phlebography was in our experience an erratic technique. Discography permitted visualization of the pattern of rupture in a degenerated disc and produced pain which could rarely be evaluated. Myelography provided the most reliable preoperative information. Forty-five patients who were operated on during the years 1958 to 1962 were re-examined one to four years later. The operation consisted in anterolateral exploration of the cervical discs and partial resection of disc tissue at one or several levels. No form of osteosynthesis was carried out in any patient. In half of the patients, the operation produced immediate relief from pain and regression of the symptoms, including tension states. Thirty-five patients with positive myelograms were followed one to four years postoperatively; twenty-nine (83 per cent) had returned to wage-earning occupations and were either completely recovered or considerably improved. Because of distressing symptoms, eight patients were operated on despite a negative myelogram. The discs resected were selected on the basis of the degree of disc degeneration on plain roentgenograms. In only one of these cases did the operation produce lasting benefit. Partial disc resection may lead to bone fusion between the vertebrae above and below the excised disc or to fibrous union. This occurred even in patients with poor results. In these unsuccessful cases, we may not have operated on the correct level or the patients may not have had disc disease. We do not consider intervertebral osteosynthesis a necessary complement to disc resection. Since excision of cervical discs must be guided by diagnostic methods which indicate the level or levels of nerve-root involvement, for the time being, myelography seems to provide the most reliable preoperative information.
pH, redox potential and local biofilm potential microenvironments within Geobacter sulfurreducens biofilms and their roles in electron transfer

The limitation of pH inside electrode‐respiring biofilms is a well‐known concept. However, little is known about how pH and redox potential are affected by increasing current inside biofilms respiring on electrodes. Quantifying the variations in pH and redox potential with increasing current is needed to determine how electron transfer is tied to proton transfer within the biofilm. In this research, we quantified pH and redox potential variations in electrode‐respiring Geobacter sulfurreducens biofilms as a function of respiration rates, measured as current. We also characterized pH and redox potential at the counter electrode. We concluded that (1) pH continued to decrease in the biofilm through different growth phases, showing that the pH is not always a limiting factor in a biofilm and (2) decreasing pH and increasing redox potential at the biofilm electrode were associated only with the biofilm, demonstrating that G. sulfurreducens biofilms respire in a unique internal environment. Redox potential inside the biofilm was also compared to the local biofilm potential measured by a graphite microelectrode, where the tip of the microelectrode was allowed to acclimatize inside the biofilm. Biotechnol. Bioeng. 2012; 109: 2651–2662. © 2012 Wiley Periodicals, Inc.