Miracle-dz/UniFAR-FTUs huggingface dataset:
Publius: a robust, tamper-evident, censorship-resistant web publishing system

We describe a system that we have designed and implemented for publishing content on the web. Our publishing scheme has the property that it is very difficult for any adversary to censor or modify the content. In addition, the identity of the publisher is protected once the content is posted. Our system differs from others in that we provide tools for updating or deleting the published content, and users can browse the content in the normal point and click manner using a standard web browser and a client-side proxy that we provide. All of our code is freely available.
Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity

Acetaminophen (APAP) is safe at therapeutic levels but causes hepatotoxicity via N-acetyl-p-benzoquinone imine-induced oxidative stress upon overdose. To determine the effect of human (h) pregnane X receptor (PXR) activation and CYP3A4 induction on APAP-induced hepatotoxicity, mice humanized for PXR and CYP3A4 (TgCYP3A4/hPXR) were treated with APAP and rifampicin. Human PXR activation and CYP3A4 induction enhanced APAP-induced hepatotoxicity as revealed by hepatic alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities elevated in serum, and hepatic necrosis after coadministration of rifampicin and APAP, compared with APAP administration alone. In contrast, hPXR mice, wild-type mice, and Pxr-null mice exhibited significantly lower ALT/AST levels compared with TgCYP3A4/hPXR mice after APAP administration. Toxicity was coincident with depletion of hepatic glutathione and increased production of hydrogen peroxide, suggesting increased oxidative stress upon hPXR activation. Moreover, mRNA analysis demonstrated that CYP3A4 and other PXR target genes were significantly induced by rifampicin treatment. Urinary metabolomic analysis indicated that cysteine-APAP and its metabolite S-(5-acetylamino-2-hydroxyphenyl)mercaptopyruvic acid were the major contributors to the toxic phenotype. Quantification of plasma APAP metabolites indicated that the APAP dimer formed coincident with increased oxidative stress. In addition, serum metabolomics revealed reduction of lysophosphatidylcholine in the APAP-treated groups. These findings demonstrated that human PXR is involved in regulation of APAP-induced toxicity through CYP3A4-mediated hepatic metabolism of APAP in the presence of PXR ligands.
International Antitrust Enforcement and Multimarket Contact

This article analyzes cartel formation and international antitrust enforcement when multinational firms operate in several jurisdictions with local antitrust authorities. We are concerned with how the sustainability of collusion in one local market is affected by the existence of collusion in other markets when they are linked by a negative demand relationship. The interdependence of cartel stability across markets leads to potential externalities in antitrust enforcement across jurisdictions. Local antitrust enforcement equilibrium enforcement may exhibit a nonmonotonicity in the degree of market integration. We compare it with globally optimal antitrust enforcement policy and discuss the role of international antitrust coordination.
Robust key generation from signal envelopes in wireless networks

The broadcast nature of a wireless link provides a natural eavesdropping and intervention capability to an adversary. Thus, securing a wireless link is essential to the security of a wireless network, and key generation algorithms are necessary for securing wireless links. However, traditional key agreement algorithms can be very costly in many settings, e.g. in wireless ad-hoc networks, since they consume scarce resources such as bandwidth and battery power. Traditional key agreement algorithms are not suitable for wireless ad-hoc networks since they consume scarce resources such as bandwidth and battery power. This paper presents a novel approach that couples the physical layer characteristics of wireless networks with key generation algorithms. It is based on the wireless communication phenomenon known as the principle of reciprocity which states that in the absence of interference both transmitter and receiver experience the same signal envelope. The key-observation here is that the signal envelope information can provide to the two transceivers two correlated random sources that provide sufficient amounts of entropy which can be used to extract a cryptographic key. In contrast, it is virtually impossible for a third party, which is not located at one of the transceiver's position, to obtain or predict the exact envelope; thus retrieve the key. Since in the presence of interference strict reciprocity property can not be maintained; our methodology is based on detecting deep fades to extract correlated bitstrings. In particular, we show how a pair of transceivers can reconcile such bitstrings and finally flatten their distribution to reach key agreement. In our constructions we use cryptographic tools related to randomness extraction and information reconciliation. We introduce "secure fuzzy information reconciliators" a tool that enables us to describe robust key generation systems in our setting. Finally we provide a computational study that presents a simulation of a wireless channel that demonstrates the feasibility of our approach and justifies the assumptions made in our analysis.
Malignant pleural mesothelioma in a child with ataxia–telangiectasia

Ataxia–telangiectasia (AT) is a hereditary disorder characterized by progressive neurological dysfunction, oculocutaneous telangiectasia, immunodeficiency, cancer susceptibility, and radiation sensitivity. Pleural neoplasms are extremely rare in the pediatric population, even in patients with AT. We describe the case of a 16‐year‐old male with AT who developed a malignant pleural mesothelioma (MPM). Benign or infectious lung and pleural diseases are common in those with AT. Hence, delayed diagnosis of respiratory neoplasms can occur in these patients. This report highlights the need of heightened vigilance in patients with AT with recurrent or persistent pleuropulmonary disease. To our knowledge, no other cases of MPM in children with AT have been reported. Pediatr Pulmonol. 2013; 48:94–97. © 2012 Wiley Periodicals, Inc.
An Approximate Algorithm for Resource Allocation Using Combinatorial Auctions

Combinatorial auctions (CAs), where users bid on combination of items, have emerged as a useful tool for resource allocation in distributed systems. However, two main difficulties exist to the adoption of CAs in time-constrained environments. The first difficulty involves the computational complexity of winner determination. The second difficulty entails the computational complexity of eliciting utility valuations for all possible combinations of resources to different tasks. To address both issues, we developed a new algorithm, seeded genetic algorithm (SGA) for finding high quality solutions quickly. SGA uses a novel representational schema that produces only feasible solutions. We compare the winner determination performance of our algorithm with Casanova, another local stochastic search procedure, on typically hard-to-solve bid distributions. We show that SGA converges to a better solution than Casanova for large problem sizes. However, for many bid distributions, exact winner determination using integer programming approaches is very fast, even for large problem sizes. In these cases, SGA can still provide significant time savings by eliminating the requirement for formulating all possible bids.
To seek or not to seek? Care-seeking behaviour among people with low-back pain

Aim: The present study sought to identify potential differences between subjects who seek care for their low-back pain problems and those who do not with respect to pain intensity, grade of disability, physical or psychosocial working conditions, individual physical and physiological factors, and lifestyle factors. Material and methods: The study population was obtained from a population-based, case-referent study, the MUSIC-Norrtälje study. All persons with low-back pain among cases as well as ``referents'' were compared according to care-seeking behaviour. In all 727 cases with low-back pain who had sought care by any of 75 caregivers in the region, including all physicians and physiotherapists as well as chiropractors, osteopaths, and homeopaths, 721 referents with low-back pain who did not seek care participated. All participants underwent a clinical examination, and filled in a questionnaire about personal and occupational data, pain and disability, pain history, psychosomatic complaints, and present psychosocial situation. Results: High disability and high pain intensity were strongly related to care seeking among men and women with low-back pain. The odds ratios for high disability were 7.4 (CI 5.0 - 11.0) for women and 4.9 (CI 3.3 - 7.1) for men respectively. The odds ratios for high pain intensity were 3.7 (CI 2.2 - 6.0) for women and 1.7 (CI 1.1 - 2.8) for men. A more strained economic situation and use of passive coping strategies significantly increased the probability of women not seeking care. Neither previous pain history, high physical workload, nor jobstrain, poor job satisfaction, or life style factors (high body weight, smoking, and exercise) or psychosomatic complaints affected care-seeking behaviour. Conclusions: The most decisive factors for seeking care were disability and pain. However, numerous individuals with low disability and low pain intensity also seek care for their pain problems. Better information and advice on the common course of low-back pain may make those individuals less frightened of their pain and, as a result, reduce the consumption of care and social costs for society. The majority of people seek care for pain without wanting a medical prescription. The fact that economic factors seemed to be of importance indicates that costs for healthcare must be kept low if the goal is to give healthcare on equal terms for all.
Phase noise analysis of a homodyne radar system driven by a phase-locked loop

An analytical model is presented to calculate phase noise spectrum and jitter of a radar system driven by a phase-locked loop (PLL). The high-pass filtered phase noise of the voltage-controlled oscillator (VCO) is modelled as an Ornstein-Uhlenbeck process. For a triangular FMCW frequency sweep, a non-stationary process is used to calculate the PLL output phase. A condition for the loop filter capacitance is derived for which the phase noise is a stationary Ornstein-Uhlenbeck process from the beginning of a frequency sweep. For the stationary case, phase noise spectrum and rms phase jitter at the receiver output are calculated analytically. The effect of noise cancellation in the radar receiver on phase noise and jitter is discussed as a function of basic PLL parameters and target distance.
Adaptive interface for text input on large-scale interactive surfaces

In this paper we present a novel approach to text input on large interactive surfaces using a combination of strategies to resolve the inherent difficulties with text input on such a device. Instead of using a conventional full size QWERTY based layout, the idea is to use a very limited set of buttons that, by using word prediction and hints, would only require minimal finger movement. The input mechanism is somewhat related to input methods employed when using keyboards with a limited size and amount of keys, commonly found in phones and other 10 digit keyboards. Given that the main motivation to this approach was not the limited size but rather to overcome the difficult task of locating keys with fingers on a flat and featureless surface, making touch-typing very difficult and requiring frequent visual monitoring of the finger position, we opted to enhance the interaction with easily made gestures, a layout that adapts to the hand anatomy of the user, and easy control over the text prediction.
FIREGUIDE: Firefighter guide and tracker

In this paper, we introduce an indoor location tracking and navigation system (FIREGUIDE) using Bluetooth and RFID technology. FIREGUIDE assists the firefighters to find the nearest exit location and presents the Incident Commander the current firefighter's location superimposed on a map of the building floor. We envision that the FIREGUIDE system will save significant number of fire fighters and victims' lives.
Synergistic Activity of Fenretinide and the Bcl-2 Family Protein Inhibitor ABT-737 against Human Neuroblastoma

Purpose: Fenretinide (4-HPR) is a cytotoxic retinoid with minimal systemic toxicity that has shown clinical activity against recurrent high-risk neuroblastoma. To identify possible synergistic drug combinations for future clinical trials, we determined whether ABT-737, a small-molecule BH3-mimetic that inhibits most proteins of the antiapoptotic Bcl-2 family, could enhance 4-HPR activity in neuroblastoma. Experimental Design: Eleven neuroblastoma cell lines were tested for the cytotoxic activity of 4-HPR and ABT-737 as single agents and in combination using the DIMSCAN fluorescence digital imaging cytotoxicity assay. The effect of these agents alone and in combination on mitochondrial membrane depolarization and apoptosis (by flow cytometry), cytochrome c release, caspases, Bax-α, t-Bid, and Bak activation, and subcutaneous xenografts in nu/nu mice was also determined. Results: Multilog synergistic cytotoxicity was observed for the drug combination in all of the 11 neuroblastoma cell lines tested, including MDR lines and those insensitive to either drug as single agents. 4-HPR + ABT-737 induced greater mitochondrial membrane depolarization and mitochondrial cytochrome c release, greater activation of caspases, Bax-α, t-Bid, and Bak, and a higher level of apoptosis than either drug alone. In vivo, 4-HPR + ABT-737 increased the event-free survival of the MDR human neuroblastoma line CHLA-119 implanted subcutaneously in nu/nu mice (194.5 days for the combination vs. 68 days for ABT-737 and 99 days for 4-HPR). Conclusion: Thus, the combination of 4-HPR with a BH3-mimetic drug warrants clinical trials in recurrent neuroblastoma. Clin Cancer Res; 17(22); 7093–104. ©2011 AACR.
Intracellular Location of the SOX9 Protein in Breast Disease

SOX9, an important factor for testis determination and chondrogenesis, was previously detected in the nucleus of testicular sertoli cells and chondrocytes but was found in only a subset of ovarian sertoli cell tumors, carcinoid tumors, and endometrioid carcinomas, and occasionally only in the cytoplasm of those cells. SOX9 has also been detected in metaplastic carcinomas of the breast exhibiting chondroid differentiation so it became of interest to examine SOX9 in other breast carcinomas and normal breast. Normal breast lobules were studied immunohistochemically for SOX9 along with examples of metaplastic breast carcinoma exhibiting chondroid differentiation, lobular neoplasia (ALH/LCIS), invasive lobular carcinomas, and ductal carcinomas (invasive and in situ). SOX9 was identified solely in the nucleus in over 90% of the normal breast epithelial cells examined. In 10 of 12 breast carcinomas exhibiting chondroid metaplasia, and in 15 of 16 invasive lobular carcinomas, SOX9 was present primarily in the nucleus much like that seen in normal breast epithelium. In 14 of 20 invasive ductal carcinomas, however, it was missing or identified mainly in the cytoplasm of the malignant cells. The functional importance of SOX9 in the breast is unknown although transcription factors involved with the development of certain tissues may have similar capabilities in other organs. The retention of SOX9 in the nucleus of metaplastic or lobular carcinomas could indicate some functional expression of this protein in these tumors with an even more compelling reason why it is often restricted to the cytoplasm, or missing, in ductal carcinomas of the breast.
Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line

Chronic exposure to elevated levels of free fatty acids (FFAs) has been shown to cause cell death (lipotoxicity), but the underlying mechanisms of lipotoxicity in hepatocytes remain unclear. We have previously shown that the saturated FFAs cause much greater toxicity to human hepatoma cells (HepG2) than the unsaturated ones (Srivastava and Chan, 2007). In this study, metabolic flux analysis (MFA) was applied to identify the metabolic changes associated with the cytotoxicity of saturated FFA. Measurements of the fluxes revealed that the saturated FFA, palmitate, was oxidized to a greater extent than the non‐toxic oleate and had comparatively less triglyceride synthesis and reduced cystine uptake. Although fatty acid oxidation had a high positive correlation to the cytotoxicity, inhibitor experiments indicated that the cytotoxicity was not due to the higher fatty acid oxidation. Application of MFA revealed that cells exposed to palmitate also had a consistently reduced flux of glutathione (GSH) synthesis but greater de novo ceramide synthesis. These predictions were experimentally confirmed. In silico sensitivity analyses identified that the GSH synthesis was limited by the uptake of cysteine. Western blot analyses revealed that the levels of the cystine transporter xCT, but not that of the GSH‐synthesis enzyme glutamyl‐cysteine synthase (GCS), were reduced in the palmitate cultures, suggesting the limitation of cysteine import as the cause of the reduced GSH synthesis. Finally, supplementing with N‐acetyl L‐cysteine (NAC), a cysteine‐provider whose uptake does not depend on xCT levels, reduced the FFA‐toxicity significantly. Thus, the metabolic alterations that contributed to the toxicity and suggested treatments to reduce the toxicity were identified, which were experimentally validated. Biotechnol. Bioeng. 2008;99: 399–410. © 2007 Wiley Periodicals, Inc.
A Generalized Momentum Framework for Looking at Baroclinic Circulations

Abstract This paper introduces the concept of potential momentum, which is a nonlocal measure of the thermal structure that has momentum units. Physically, it may be interpreted as the zonal momentum that the flow would realize through an adiabatic redistribution of mass that made the isentropic thickness uniform poleward of a reference latitude. At the surface, a poleward temperature gradient is equivalent to an easterly reservoir of potential momentum. Potential momentum gives a global picture of the thermal field that also takes into account the meridional structure. When the mean flow is redefined in terms of the total momentum (the standard zonal momentum plus this newly defined potential momentum), the mean-flow response to the eddy forcing can be formulated locally. This allows one to relate in equilibrium the eddy absorption and the restoration of the mean flow. Using the concept of potential momentum, vertical propagation can be related to thermal forcing by means of an equation analogous to the .
A Regression Model for Predicting Shape Deformation after Breast Conserving Surgery

Breast cancer treatments can have a negative impact on breast aesthetics, in case when surgery is intended to intersect tumor. For many years mastectomy was the only surgical option, but more recently breast conserving surgery (BCS) has been promoted as a liable alternative to treat cancer while preserving most part of the breast. However, there is still a significant number of BCS intervened patients who are unpleasant with the result of the treatment, which leads to self-image issues and emotional overloads. Surgeons recognize the value of a tool to predict the breast shape after BCS to facilitate surgeon/patient communication and allow more educated decisions; however, no such tool is available that is suited for clinical usage. These tools could serve as a way of visually sensing the aesthetic consequences of the treatment. In this research, it is intended to propose a methodology for predict the deformation after BCS by using machine learning techniques. Nonetheless, there is no appropriate dataset containing breast data before and after surgery in order to train a learning model. Therefore, an in-house semi-synthetic dataset is proposed to fulfill the requirement of this research. Using the proposed dataset, several learning methodologies were investigated, and promising outcomes are obtained.
Analysis of radial breathing-mode of nanostructures with various morphologies: a critical review

Knowledge about the vibrational characteristics of nanostructures is of fundamental interest, since it is a signature of their morphology and it can be utilised to predict their material properties. Radial breathing-mode (RBM) is a special vibrational mode, displayed by the nanostructures, and can be observed experimentally. Over the past two decades, the study of the RBM of the nanostructures has attracted much attention because of its importance in such applications as structural and material property characterisations. This paper reviews recent theoretical and experimental studies on the RBM frequencies of nanostructures with various morphologies. There is a one-to-one correspondence between the geometrical characteristics of the nanostructures and their RBM frequencies. An overview of the current literature discussing the RBM frequency of carbon nanostructures and their geometrical characterisation is presented first. Authors then discuss the theoretical and experimental studies on the breathing-modes of spherical nanoparticles. Different approaches, which have been utilised to obtain the RBM frequency of circular nanowires, are then reviewed. Finally, conclusions and recommendations for further research in this field are provided. To the best of our knowledge, a specialised review addressing the RBM of the nanostructures has not been available so far. This work is likely to fill this gap.
Effect of menstrual cycle on HIV-1 levels in the peripheral blood and genital tract. WHS 001 Study Team.

OBJECTIVE To assess the variation in HIV-1 over the menstrual cycle, including RNA levels in the female genital tract, plasma HIV-1-RNA levels, CD4 cell counts, and culturable virus. DESIGN A prospective analysis of 55 HIV-1-infected women. METHODS Blood and genital tract specimens were collected weekly over 8 weeks, spanning two complete menstrual cycles. Applying repeated-measures models that used menses as the reference level, the variation in viral RNA levels was compared in endocervical canal fluid and cells (collected by Sno-strips and cytobrush, respectively) and ectocervicovaginal lavage (CVL) fluid. Repeated-measures models were also used to assess the variation in plasma CD4 cell counts and viral load. RESULTS Shedding patterns differed among the three sampling methods, independent of genital tract co-infections. Genital tract HIV-1-RNA levels from CVL fluid and endocervical canal cytobrush specimens were highest during menses and lowest immediately thereafter (P = 0.001 and P = 0.04). The HIV-1-RNA level in endocervical canal fluid was highest in the week preceding menses (P = 0.003). The menstrual cycle had no effect on blood levels of RNA (P = 0.62), culturable virus (P = 0.34), or CD4 cell counts (P = 0.55). HIV-1-RNA levels were higher in endocervical canal fluid than in peripheral blood plasma during the late luteal phase (P = 0.03). CONCLUSION HIV-1-RNA levels vary with the menstrual cycle in the female genital tract but not the blood compartment. HIV-1-RNA levels are higher in endocervical canal fluid than in blood plasma. These findings may have important implications for sex-specific pathogenesis, heterosexual transmission, and contraceptive hormone interventions in HIV-1-infected women.