Miracle-dz/UniFAR-FTUs huggingface dataset:
The value of the TIMI frame count method in the diagnosis of coronary no-reflow: a comparison with myocardial perfusion SPECT in patients with acute myocardial infarction

The state of no-reflow (i.e. inadequate myocardial tissue perfusion despite normal arterial flow proven in angiography after pharmacological or mechanical interventions) is considered to be a marker of a poor prognosis. Although the Thrombolysis in Myocardial Infarction (TIMI) flow grade is a valuable and widely used qualitative measure in angiography trials, it is limited by its subjective and categorical nature. Recently, the TIMI frame count method (TFC) was proposed for detecting no-reflow. In our study we aimed to compare TFC values with myocardial perfusion single photon emission computed tomography (SPECT) findings to investigate the additional role of the former method in the evaluation of no-reflow. Twenty patients (16 men and four women; mean age 58±9 years) with first acute myocardial infarction were included in the study after thrombolytic therapy. Coronary angiography (CAG) was performed 5-7 days later. The TIMI flow grade and TFC values were determined in angiography examinations. A TIMI flow of less than grade 3 and a TFC value >27 were considered to be pathologically decreased for coronary artery blood flow. 99mTc tetrofosmin myocardial rest SPECT was carried out 24 h after coronary angiography. SPECT images were scored on a four-point scale in 20 myocardial segments and the total defect score was calculated from the sum of defect scores in 20 segments. Wall motion was assessed using the wall motion score index in echocardiography (ECWSI). The occurrence rates of angiographic no-reflow, pathological TFC and perfusion defects in SPECT were calculated as 40% (8/20), 47% (8/17; non-measurable in three patients with TIMI grade 0), and 55% (11/20), respectively. Perfusion defects were present and the TIMI frame count value was increased in all patients with angiographic no-reflow (TIMI grade <3). The occurrence rate of perfusion defects and increased TFC was equal (42%) in all 12 patients having TIMI grade 3 flow. Increased TFC was demonstrated in four of five patients having perfusion defects and TIMI grade 3 flow (80% compatibility with SPECT). TIMI frame count and ECWSI values were significantly higher in patients having perfusion defects than in patients with normal perfusion (P<0.05). It is concluded that the TIMI frame count is a valuable method in the detection of patients with TIMI grade 3 flow, with no-reflow, and increases the specificity of coronary angiography in the evaluation of the response to thrombolytic therapy. A pathologically increased TFC value with TIMI grade 3 flow during CAG seems to be a good indication for the use of myocardial perfusion SPECT in the definitive diagnosis and/or follow-up of such patients.
Robust resource allocation for multi-tier cognitive heterogeneous networks

How to improve system capacity and spectral efficiency is a key issue for next generation wireless communication. Heterogeneous network (HetNet) has been considered as a new promising technique for enhancing the quality of service and spectrum efficiency due to different radio access technology and network structures. However, conventional resource allocation algorithms in HetNets are achieved under the assumption of perfect parameter information which may be invalid in practical systems. In this paper, a robust rate maximization resource allocation problem for multiuser cognitive HetNets is formulated to flexibly use network resource and improve overall capacity where robust cross-tier interference constraint and maximum transmit power constraint of base station are simultaneously considered. The semi-infinite programming problem is converted into a geometric programming problem by using relaxation approaches. Simulation results show that the proposed algorithm can guarantee transmission performance of macrocell users and microcell users under channel uncertainties.
Comparison of two visual methods for detecting caries among obese and non-obese children

Abstract Objective: The study aimed to compare two visual methods for detecting caries among obese and non-obese children in Salvador, Brazil. Materials and methods: A cross-sectional study was conducted from 2011–2012, which evaluated 180 paediatric patients, 6–14 years old, girls and boys, categorized into two groups: obese and non-obese (healthy weight), according to the body mass index. For the evaluation of dental caries, the decayed, missing or filled teeth index (DMFT/dmft) and International Caries Detection and Assessment System II (ICDAS II) visual criteria were used. Results: The mean DMFT value was 0.98 in obese children and 0.57 in the non-obese children, without significant differences between groups (p = 0.206). The mean dmft value in the non-obese children (1.66) was higher than in obese children (0.95), with significant differences between groups (p = 0.021). According to ICDAS II criteria, there was a higher prevalence of non-cavitated enamel lesions (D1–3) in obese children (n = 156, 10.5%) compared to the non-obese children (n = 55, 1.9%), with significant differences between the groups (p < 0.001). Conclusions: The inclusion of non-cavitated lesions during the caries evaluation represents a challenge in diagnosis, which allows for control of this process before the evolution of these lesions to cavitation.
Partial Indexing for Nonuniform Data Distributions in relational DBMS's

It is well known that the effectiveness of relational database systems is greatly dependent on the efficiency of the data access strategies. For this reason, much work has been devoted to the development of new access techniques, supported by adequate access structures such as the B/sup +/trees. The effectiveness of the B/sup +/tree also depends on the data distribution characteristics; in particular, poor performance results when the data show strong key value distribution unbalancing. The aim of this paper is to present the partial index: a new access structure that is useful in such cases of unbalancing, as an alternative to the B/sup +/tree unclustered indexes. The access structures are built in the physical design phase, and at execution (or compilation) time, the optimizer chooses the most efficient access path. Thus, integration of the partial indexing technique in the design and in the optimization process are also described. >
Interaction between RNA Polymerase and RapA, a Bacterial Homolog of the SWI/SNF Protein Family*

Recently, we identified a novel Escherichia coli RNA polymerase (RNAP)-associated protein, an ATPase, called RapA (Sukhodolets, M. V., and Jin, D. J. (1998) J. Biol. Chem. 273, 7018–7023). RapA is a bacterial homolog of SWI2/SNF2. We showed that RapA forms a stable complex with RNAP holoenzyme and that binding to RNAP holoenzyme stimulates the ATPase activity of RapA. We have further analyzed the interactions between purified RapA and the two forms of RNAP: core RNAP and RNAP holoenzyme. We found that RapA interacts with either form of RNAP. However, RapA exhibits higher affinity for core RNAP than for RNAP holoenzyme. Chemical cross-linking of the RNAP-RapA complex indicated that the RapA-binding sites are located at the interface between the α and β′ subunits of RNAP. Contrary to previously reported results (Muzzin, O., Campbell, E., A., Xia, L., Severinova, E., Darst, S. A., and Severinov, K. (1998) J. Biol. Chem. 273, 15157–15161), our in vivo analysis of a rapAnull mutant suggested that RapA is not likely to be directly involved in DNA repair.
Therapeutic Transfusions of Previously Frozen Washed Human Platelets

The platelets used in this study were collected by serial centrifligation, and within four hours of collection were frozen with 5% dimethylsulfoxide (DMSO) at an overall rate of 2 to 3 C per minute by storage in a mechanical refrigerator at ‐80 C. The frozen platelets were stored for four to ten weeks before thawing and washing. After washing, the units were kept at room temperature for six to eight hours before transfusion. The units were pooled, and an average of eight units was given to each of four patients, with a range of three to 14 units per transfusion. In vitro recovery after washing was about 65 per cent and in vivo recovery of the 51chromium labeled (51Cr) platelets was about 35 per cent. The infusion of these previously frozen washed platelets corrected prolonged bleeding times in patients. The homologous platelets were transfused along with other blood products to treat patients with hematologic disorders. The circulation and function of the donor platelets were influenced by compatibility of the platelets, the quality of platelet preservation and the patient's disease state.
Pharmacognostic, Phytochemical and Anti-microbial studies of Solanum indicum leaves

The leaves of Solanum indicum showed the presence of stellate trichome. Ethanolic extract of leaves Solanum indicum showed antibacterial activity against Staphylococcus aureus, Bacillus cereus, Escherichia coli where as chloroform extract, acetone extract and ethanol showed anti bacterial against pseudomonas. The aqueous extract did not show any anti microbial activity towards the tested organism. None of the extract showed anti fungal activity.
Electrical and mechanical controlling of the kinetic and magnetic properties of hydrogen atoms on free-standing silicene

Effects of strain, charge doping and external electric field on kinetic and magnetic properties of hydrogen atoms on a free-standing silicene layer are investigated by first-principles density functional theory. It was found that the charge doping and strain are the most effective ways of changing the hydrogen-silicene binding energy, but they can only raise its value. The perpendicular external electric field can also lower it albeit in a narrower range. The strain has also the strongest impact on diffusion processes, and the diffusion barrier can be modified up to 50% of its unstrained value. The adsorption of hydrogen atoms results in a locally antiferromagnetic ground state with the effective exchange constant of approximately 1 eV. The system can easily be driven into a nonmagnetic phase by the charge doping and strain. The obtained results are very promising in view of the silicene functionalization and potential applications of silicene in fields of modern nanoelectronics and spintronics.
Amplification on double‐minute chromosomes and partial‐tandem duplication of the MILL gene in leukemic cells of a patient with acute myelogenous leukemia

Partial‐tandem duplication (PTD) of an internal portion of MLL occurs in some cases of acute myelogenous leukemia (AML) with trisomy 11 or a normal karyotype. This type of MLL rearrangement may be transcribed into an mRNA species that is capable of encoding a partially duplicated protein associated with leukemogenesis. However, although several kinds of oncogenes, especially MYC, are often amplified on double‐minute chromosomes (dmins) in hematological malignancies, no amplification of MLL has been reported in AML. Here, we report the first documented case of a patient with AML whose leukemic cells exhibited amplification of MLL on dmins. Furthermore, in this patient, MLL was rearranged in a PTD manner, with in‐frame fusion of exons 2 and 6. Genes Chromosomes Cancer 23:267–272, 1998. © 1998 Wiley‐Liss, Inc.
Clinical Conference Orthostatic Hypotension

A 29-year-old white woman (weight, 1211b; height, 5 ft 6 in.) was referred to the Hypertension Unit of Massachusetts General Hospital in December 1984. She had been athletic and apparently in excellent health until September 1979 when she contracted an upper respiratory tract infection associated with wheezing. She was treated with prednisone for 5 days with resolution of the symptoms but later noted a progressive decline in her exercise tolerance with shortness of breath. She lost 15 to 20 lb over the next 2 to 3 months, and then in November 1979 she began experiencing episodes of "faintness," initially every 1 to 2
Energy efficient 3D Hybrid processor-memory architecture for the dark silicon age

With increasing the number of cores on the Chip-Multiprocessors (CMPs) as a result of continuous technology scaling, more cache resources are needed to feed all the cores. Hence, in order to improve performance by reducing off-chip memory access, inevitably on-chip caches should be increased. In on-chip cache hierarchy, last level cache (LLCs) is the largest one consuming more energy compared with the other levels in many-core CMPs as leakage power within the LLC has become a significant contributor in the overall chip power budget in deep sub-micron as well as dark silicon era. In this paper, we focus on exploiting Non-Volatile Memory (NVM) which is a new type of memory with promising features in shared distributed LLCs to decrease the leakage power consumption and mitigating the dark silicon phenomenon. In our proposed strategy, we first calculate Average Memory Access Time (AMAT) of running applications on the CMP in each predetermined interval by collected systems memory traffic. Based on the monitored AMATs, we then adaptively reconfigure Hybrid distributed LLC by selecting the proper memory type (i.e., SRAM bank or STT-RAM bank) at runtime. Experiment results on the PARSEC benchmarks show that the proposed method provides up to 55.22% (on average 39.3%) energy reduction and 35.33% on average energy-delay product (EDP) improvement with only 6% performance degradation compared to the conventional methods where single cache technology is used.
Identification of blood pressure quantitative trait loci that differentiate two hypertensive strains

Objective To describe genetic loci that differentiate blood pressures in two genetically hypertensive strains, the Dahl salt-sensitive (S) rat and the Albino Surgery (AS) rat. Methods A genome scan was performed using 222 genetic markers on an F2 population derived from two hypertensive strains, S and AS. The F2 rats were fed 8% NaCl for 5 weeks before blood pressure measurements were taken. Results Three blood pressure quantitative trait loci (QTL) were detected, one on each of rat chromosomes (RNO) 2, 4 and 8. The QTL on RNO4, unlike those on RNO2 and RNO8, was not detected in any of the previous seven linkage analyses reported with the S rat as one of the parental strains. Interactions between genetic loci throughout the genome were sought and interactions involving RNO4 with RNO8 and RNO4 with RNO14 were found. Including the new RNO4 locus identified in the present study, 16 distinct regions of the S rat genome have been demonstrated, by linkage analyses, to harbour loci that control blood pressure in the S rat. Conclusions Increased blood pressure in two hypertensive strains, S and AS, is differentially regulated by genetic factors present on RNOs 2, 4 and 8. Therefore, of the 16 distinct genomic regions known to harbour blood pressure QTL in S rats, 13 are likely to contain blood pressure alleles that function similarly in the S rat and the AS rat, whereas three regions differentiate the two strains.
Image Analysis of the 2012 Pluto (Near) Occultation

Abstract : Imagery was gathered at the AMOS observatory on the 3.6-meter telescope for the expected occultation of a star by the dwarf planet, Pluto, on 29 June 2012. The imagery was taken at 5 Hz for 40 minutes before and after the expected time of occultation. The initial analysis of the photometry indicated that Pluto did not occult the star. This conclusion could not be determined from a simple visual inspection of the imagery. Understanding why and by how much Pluto missed occulting the star can aid in predicting future occultations. To analyze the imagery, a least squares method was developed to measure the closest approach, in arc seconds. The method is based on averaging the modulus squared of the Fourier transform of the imagery. This is similar to Labeyrie s technique in speckle interferometry. From this method, fringes were detected and measured as a function of time over the period before and after the near occultation. The analysis showed that Pluto missed the star by 0.135 arcsec with an accuracy of 0.003 arcsec. The use of over 24,000 image frames leads to this high level of precision. In addition, Labeyrie s technique applied to the images of Pluto by itself, shows that Pluto and its moon, Charon, were oriented perpendicularly to the direction of travel, making it even less likely that Pluto would overlap with the star. The methods developed to conduct this analysis and the conclusions reached are described in this paper.
Building Weighted Associative Classifiers using Maximum Likelihood Estimation to Improve Prediction Accuracy in Health Care Data Mining

Associative classifiers are new classification approach that use association rules for classification. An important advantage of these classification systems is that, using association rule mining (ARM) they are able to examine several features at a time. Many applications can benefit from good classification model. Associative classifiers are especially fit to applications where the model may assist the domain experts in their decisions. Medical diagnosis is a domain where the maximum accuracy of the model is desired. In this paper, we propose a framework weighted associative classifier (WAC) that assigns different weights to different attributes according to their predicting capability. We are using maximum likelihood estimation (MLE) theory to calculate weight of each attribute using training data. We also show how existing Apriori algorithm can be modified in weighted environment to infer association rule from medical dataset having numeric valued attributes as the conventional ARM usually deals with the transaction database with categorical values. Experiments have been performed on benchmark data set to evaluate the performance of WAC in terms of accuracy, number of rules generating and impact of minimum support threshold on WAC outcomes. The result reveals that WAC is a promising alternative in medical prediction and certainly deserves further attention.
Polymorphisms in the p53 pathway genes and micronucleus occurrence in Chinese vinyl chloride-exposed workers

ObjectivesTo investigate the association between polymorphisms in the p53 pathway genes and chromosomal damage in vinyl chloride (VC)-exposed workers.Materials and MethodsCytokinesis block micronucleus test was performed in 310 VC-exposed workers and 149 non-exposed workers to determine chromosomal damage. The polymerase chain reaction and restriction fragment length polymorphism technique were used to detect six SNPs in the p53 pathway genes involved in the cell cycle.ResultsThere was a highly significant dose-response relationship between VC exposure and chromosomal damage. Individuals carrying the variant genotypes were at higher risk for chromosomal damage compared with their wild type genotype: p53rs1042522, MDM2 Del1518rs3730485, MDM2rs2279744 and GADD45Ars532446. On the other hand, individuals possessing the variant genotype of CDKN2A rs3088440 had significantly decreased risk compared with the corresponding wild-type.ConclusionsGenetic polymorphisms in P53 pathway genes may have an impact on VC-induced chromosomal damage.
Changes in running kinematics, kinetics, and spring-mass behavior over a 24-h run.

PURPOSE This study investigated the changes in running mechanics and spring-mass behavior over a 24-h treadmill run (24TR). METHODS Kinematics, kinetics, and spring-mass characteristics of the running step were assessed in 10 experienced ultralong-distance runners before, every 2 h, and after a 24TR using an instrumented treadmill dynamometer. These measurements were performed at 10 km·h, and mechanical parameters were sampled at 1000 Hz for 10 consecutive steps. Contact and aerial times were determined from ground reaction force (GRF) signals and used to compute step frequency. Maximal GRF, loading rate, downward displacement of the center of mass, and leg length change during the support phase were determined and used to compute both vertical and leg stiffness. RESULTS Subjects' running pattern and spring-mass behavior significantly changed over the 24TR with a 4.9% higher step frequency on average (because of a significantly 4.5% shorter contact time), a lower maximal GRF (by 4.4% on average), a 13.0% lower leg length change during contact, and an increase in both leg and vertical stiffness (+9.9% and +8.6% on average, respectively). Most of these changes were significant from the early phase of the 24TR (fourth to sixth hour of running) and could be speculated as contributing to an overall limitation of the potentially harmful consequences of such a long-duration run on subjects' musculoskeletal system. CONCLUSIONS During a 24TR, the changes in running mechanics and spring-mass behavior show a clear shift toward a higher oscillating frequency and stiffness, along with lower GRF and leg length change (hence a reduced overall eccentric load) during the support phase of running.
Inhaled Nitric Oxide Attenuates Hyperoxic Lung Injury in Lambs

Cytochrome P450 (CYP) inhibition with cimetidine reduces hyperoxic lung injury in young lambs. Nitric oxide (NO), also a CYP inhibitor, has been shown to either aggravate or protect against oxidant stress depending on experimental context. The objective of this study was to determine whether NO, like cimetidine, would protect young lambs against hyperoxic lung injury, and whether its effect was associated with CYP inhibition. Three groups of lambs were studied: 1) room air exposure, 2) >95% O2, and 3) >95% O2 plus inhaled NO. After 72 h, hyperoxia alone resulted in a significant increase in arterial Pco2 and number of polymorphonuclear leukocytes in bronchoalveolar lavage (BAL), and a significant decrease in arterial/alveolar O2 tension (a/A). The addition of inhaled NO significantly decreased the hypercarbia and BAL polymorphonuclear cellular response associated with hyperoxia but had no beneficial effect on a/A ratio. There were no significant differences in F2-isoprostanes or isofurans (markers of lipid peroxidation) measured in BAL or lung tissue among study groups. No intergroup differences were detected in BAL epoxyeicosatrienoic acid levels (index of CYP activity). The results of this study indicate that hypercarbia and inflammation accompanying hyperoxic lung injury in young lambs can be attenuated by inhaled NO. However, this study provides no direct evidence that NO is inhibiting CYP-mediated oxidant lung injury.