Miracle-dz/UniFAR-FTUs huggingface dataset:
DNSNAv 4 : DNS Name Autoconfiguration for Internet-of-Things Devices in IPv 4 Networks

This paper proposes a Domain Name System (DNS) Name Autoconfiguration called DNSNAv4 for Internet-of-Things (IoT) Devices in Internet Protocol (IP) version 4 (IPv4). The manual configuration of domain names of devices might be a cumbersome burden for users as the number of devices increases. A legacy scheme called DNS Name Autoconfiguration (DNSNA) for IPv6 networks can be used to register DNS names of IPv6 IoT devices automatically into a DNS system. However, the legacy scheme called DNSNA is not applicable in the current networks because most of networks in the Internet are mostly set up for IPv4. In this paper, we propose DNSNAv4 to support suitable functionality to let the legacy scheme of DNSNA provide DNS naming services to IoT devices in the IPv4 environment. In DNSNAv4, an IoT device can register devices by interacting with a dynamic host configuration protocol (DHCP) server so that the devices can register their DNS names and the corresponding IPv4 addresses into a DNS server through a DHCP server. Therefore, with the standard protocol of DHCP, DNSNAv4 can provide users with easy DNS name autoconfiguration of their IoT devices in the IPv4 environment.
Genetic similarity and hatching success in birds

The ecological correlates of fitness costs of genetic similarity in free–living, large populations of organisms are poorly understood. Using a dataset of genetic similarity as reflected by band–sharing coefficients of minisatellites, we show that bird species with higher genetic similarity experience elevated hatching failure of eggs, increasing by a factor of six across 99 species. Island distributions and cooperative breeding systems in particular were associated with elevated genetic similarity. These findings provide comparative evidence of detrimental fitness consequences of high genetic similarity across a wide range of species, and help to identify ecological factors potentially associated with increased risk of extinction.
Concordance between cl i n i cal and patholog i cal stag i ng i n pat i ents w i th stages I or II non-small cell lung cancer subjected to surg i cal treatment *

Objective: To compare clinical and pathological staging in patients with non-small cell lung cancer submitted to surgical treatment, as well as to identify the causes of discordance. Methods: Data related to patients treated at the Department of Thoracic Surgery of the Pontifical Catholic University of Rio Grande do Sul São Lucas Hospital were analyzed retrospectively. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated for clinical stages IA, IB, and IIB. The kappa index was used to determine the concordance between clinical and pathological staging. Results: Of the 92 patients studied, 33.7% were classified as clinical stage IA, 50% as IB, and 16.3% as IIB. The concordance between clinical and pathological staging was 67.5% for stage IA, 54.3% for IB, and 66.6% for IIB. The accuracy of the clinical staging was greater for stage IA, and a kappa of 0.74, in this case, confirmed a substantial association with pathological staging. The difficulty in evaluating nodal metastatic disease is responsible for the low concordance in patients with clinical stage IB. Conclusions: The concordance between clinical and pathological staging is low, and patients are frequently understaged (in the present study, only one case was overstaged). Strategies are necessary to improve clinical staging and, consequently, the treatment and prognosis of patients with non-small cell lung cancer.
Integrative physical oncology

Cancer is arguably the ultimate complex biological system. Solid tumors are microstructured soft matter that evolves as a consequence of spatio‐temporal events at the intracellular (e.g., signaling pathways, macromolecular trafficking), intercellular (e.g., cell–cell adhesion/communication), and tissue (e.g., cell–extracellular matrix interactions, mechanical forces) scales. To gain insight, tumor and developmental biologists have gathered a wealth of molecular, cellular, and genetic data, including immunohistochemical measurements of cell type‐specific division and death rates, lineage tracing, and gain‐of‐function/loss‐of‐function mutational analyses. These data are empirically extrapolated to a diagnosis/prognosis of tissue‐scale behavior, e.g., for clinical decision. Integrative physical oncology (IPO) is the science that develops physically consistent mathematical approaches to address the significant challenge of bridging the nano (nm)–micro (µm) to macro (mm, cm) scales with respect to tumor development and progression. In the current literature, such approaches are referred to as multiscale modeling. In the present article, we attempt to assess recent modeling approaches on each separate scale and critically evaluate the current ‘hybrid‐multiscale’ models used to investigate tumor growth in the context of brain and breast cancers. Finally, we provide our perspective on the further development and the impact of IPO. WIREs Syst Biol Med 2012, 4:1–14. doi: 10.1002/wsbm.158
Novel One-step Mechanism for tRNA 3′-End Maturation by the Exoribonuclease RNase R of Mycoplasma genitalium*

Background: Mycoplasma genitalium lacks known ribonucleases for tRNA 3′-processing. The only identified exoribonuclease, RNase R, can carry out this function. Results: RNase R processes the tRNA 3′-end depending on the acceptor stem, discriminator, and CCA terminus. Conclusion: RNase R can process tRNA by recognizing features within the tRNA. Significance: M. genitalium may process tRNA 3′-end employing a unique single-step exonucleolytic pathway. Mycoplasma genitalium is expected to metabolize RNA using unique pathways because its minimal genome encodes very few ribonucleases. In this work, we report that the only exoribonuclease identified in M. genitalium, RNase R, is able to remove tRNA 3′-trailers and generate mature 3′-ends. Several sequence and structural features of a tRNA precursor determine its precise processing at the 3′-end by RNase R in a purified system. The aminoacyl-acceptor stem plays a major role in stopping RNase R digestion at the mature 3′-end. Disruption of the stem causes partial or complete degradation of the pre-tRNA by RNase R, whereas extension of the stem results in the formation of a product terminating downstream at the new mature 3′-end. In addition, the 3′-terminal CCA sequence and the discriminator residue influence the ability of RNase R to stop at the mature 3′-end. RNase R-mediated generation of the mature 3′-end prefers a sequence of RCCN at the 3′ terminus of tRNA. Variations of this sequence may cause RNase R to trim further and remove terminal CA residues from the mature 3′-end. Therefore, M. genitalium RNase R can precisely remove the 3′-trailer of a tRNA precursor by recognizing features in the terminal domains of tRNA, a process requiring multiple RNases in most bacteria.
Computers in a Human Perspective: an Alternative Way of Teaching Informatics to Health Professionals

Abstract: An alternative way of teaching informatics, especially health informatics, to health professionals of different categories has been developed and practiced. The essentials of human competence and skill in handling and processing information are presented parallel with the essentials of computer-assisted methodologies and technologies of formal language-based informatics. Requirements on how eventually useful computer-based tools will have to be designed in order to be well adapted to genuine human skill and competence in handling tools in various work contexts are established. On the basis of such a balanced knowledge methods for work analysis are introduced. These include how the existing problems at a workplace can be identified and analyzed in relation to the goals to be achieved. Special emphasis is given to new ways of information analysis, i.e. methods which even allow the comprehension and documentation ofthose parts of the actually practiced ´human´ information handling and processing which are normally overlooked, as e. g. non-verbal communication processes and so-called ´tacit knowledge´ based information handling and processing activities. Different ways of problem solving are discussed involving in an integrated human perspective - alternative staffing, enhancement of the competence of the staff, optimal planning of premises as well as organizational and technical means. The main result of this alternative way of education has been a considerably improved user competence which in turn has led to very different designs of computer assistance and man-computer interfaces. It is the purpose of this paper to give a brief outline of the teaching material and a short presentation of the above mentioned results. Special emphasis is given to that part of the course where computer assisted interactive media technology presently is introduced due to the fact that this is the only way of adequately presenting some of the most important parts of human performance in handling and processing information, including communication.
Cell-Type Specific Targeting and Gene Expression Using a Variant of Polyoma VP1 Virus-Like Particles

Abstract The variant VP1-Z of the polyomavirus coat protein VP1 has been recently described as an engineered fusion protein of VP1 and the antibody binding domain protein Z. This construct is able to specifically bind and functionally present antibodies on the surface of viruslike particles of VP1-Z. Here we demonstrate that with the binding of Herceptin, an antibody directed against the receptor tyrosine kinase ErbB2, a cell typespecific targeting was established. ErbB2-positive cell lines were transduced with different plasmids encoding eGFP or β-galactosidase. With both reporter systems functional gene expression in transduced cells could be observed. The transduction was strictly dependent on the use of a ternary complex formed of VLPs of VP1- Z, Herceptin, and the reporter plasmid DNA. The use of single components or ErbB2-negative cell lines did not result in functional gene transfer. The transduction was also completely dependent on the use of chloroquine, a lysosomotropic reagent. This indicates that the complex is internalized by ErbB2-mediated endocytosis.
Audio-Visual Speech Recognition for a Person with Severe Hearing Loss Using Deep Canonical Correlation Analysis

Recently, we proposed an audio-visual speech recognition system based on a neural network for a person with an articulation disorder resulting from severe hearing loss. In the case of a person with this type of articulation disorder, the speech style is quite different from that of people without hearing loss, making a speaker-independent acoustic model for unimpaired persons more or less useless for recognizing it. Our proposed system has shown high performance; however, some problems remain. Although the feature extraction networks are trained using the phone labels as the target class, it is difficult to obtain the correct alignment for their speech. Also, it is necessary to consider a gap between audio and visual feature spaces to treat the different modalities. In this paper, we propose a feature extraction method using deep canonical correlation analysis to tackle these weaknesses. The effectiveness of this approach was confirmed through word-recognition experiments in noisy environments, where our feature extraction method outperformed the conventional methods.
Pervasive edge data sharing in MANET

The proliferation and daily congregation of modern mobile devices have created abundant opportunities for peer edge devices to share valuable data with each other. The short contact durations, relatively small sharing sizes, and uncertain data availability, demand agile, light weight peer based data sharing. In this paper, we propose Peer Data Sharing (PDS) that enables edge devices to discover which data exist in nearby peers, and retrieve interested data robustly and efficiently. We use Wi-Fi ad hoc network as an example to demonstrate that PDS can leverage different underlying network and link technologies with proper adaption. Extensive evaluations show that PDS discovers and retrieves almost 100% data in tens of seconds, and remains robust despite wireless contention, simultaneous consumer requests and user mobility.
Sub‐wavelength region spectroscopy and local morphology of individual mesoscopic quantum systems

Results of reflection microscopy and local reflection spectroscopy of J‐aggregates of two pseudoisocyanine dyes in a thin film polymer matrix are reported. The individual J‐aggregates assemble into fibre‐like shapes of large structural heterogeneity. Reflectance spectra obtained at different samples, different locations on one sample and even at different positions of the same aggregate fibre reveal a wide distribution of optical properties. The shapes and absolute reflectivities of the spectra are suggested to originate from varying strengths of exciton–photon interaction and from the effect of finite thickness of the aggregate fibres. Polarization dependence measurements of local reflectivities provide orientations of the exciton transition dipole moments at 572 nm and 540 nm with respect to the orientation of the aggregate fibres. Furthermore, modified synthesis of capped semiconductor nanocrystals of CdSe is presented. The method yields high quality quantum dots suitable for microscopic imaging and spectroscopy.
Des anaphores associatives méronymiques aux anaphores associatives locatives

Dans un 1 e r temps, l'A. se propose de justifier la separation des anaphores associatives (AA) du type Nous entrâmes dans un village. L'eglise etait situee sur une butte, ou AA locatives, des AA du type Il s'abrita sous un tilleul. Le tronc etait tout craquele, ou AA meronymique en montrant que les deux n'ont pas le meme moteur d'inference : les secondes mettent en jeu la relation semantique de meronymie (ou de partie-tout), les premieres s'etablissent sur une relation semantique locative. Dans un 2 e temps, il s'attache a definir les relations locatives, canoniques et facultatives, et a mettre en relief leurs proprietes. Cette etude permet ainsi de constituer une typologie plus complete et plus precise des AA
2 1 Se p 20 15 SIS epidemic propagation on hypergraphs

Mathematical modeling of epidemic propagation on networks is extended to hypergraphs in order to account for both the community structure and the nonlinear dependence of the infection pressure on the number of infected neighbours. The exact master equations of the propagation process are derived for an arbitrary hypergraph given by its incidence matrix. Based on these, moment closure approximation and mean-field models are introduced and compared to individual-based stochastic simulations. The simulation algorithm, developed for networks, is extended to hypergraphs. The effects of hypergraph structure and the model parameters are investigated via individual-based simulation results.
Association of Traits of Metabolic Syndrome With Glucose Abnormalities

The association of glucose abnormalities (GAs) with the early appearance of traits of the metabolic syndrome (MS) was studied in an unselected sample of apparently healthy Urban Hispanics. GAs were defined as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and newly diagnosed diabetes mellitus (DM). Overall, GAs were associated with older age, abdominal obesity, low high-density lipoprotein cholesterol levels, hypertriglyceridemia, hyperinsulinemia, hypertension, and MS. Prevalence of MS defined as per NCPE-ATPIII was the greatest in subjects with DM (54.3%) and with combined abnormalities (IFG + IGT) (54.1%; P > 0.5). Similar prevalence of MS was found in subjects with isolated IFG (34.3%) and isolated IGT (36.8%) but higher than in normal fasting-glucose tolerant individuals (23.3%) (P < 0.01). The average number of traits of the MS coexisting in normal fasting glucose–tolerant individuals was 1.6 [95% confidence interval (CI), 1.5–1.8; median 2], in isolated IFG: 2.05 (95% CI, 1.8–2.2; median 2); isolated IGT: 2.16 (95% CI, 1.8–2.3; median 2); combined IFG + IGT: 2.7 (95% CI, 2.3–3.1; median 3); and DM: 2.7 (95% CI, 2.25–3.1; median 3) (P < 0.01). Postload insulin levels were higher in isolated IGT than in isolated IFG, whereas HOMA-IR was higher in IFG. Indices of early and total insulin secretion were markedly reduced in DM, IFG–IGT, and IGT. In conclusion, GAs are strongly associated with the number and severity of traits of the MS, defects in insulin secretion, and sustained hyperinsulinemia in response to oral glucose. Subjects with combined GA and newly diagnosed type 2 DM had not only an increased prevalence of MS, but also the MS was characterized by the presence of more than 3 traits, and by a greater severity of each of the coexisting traits.
On Probabilistic Application Compliance

The Security-by-Contract is a paradigm developed to offer a secure environment in which mobile applications can be executed by respecting the security policies of interest. Especially in the Android Apps marketplace, establishing precisely the expected secure app behavior is typically a complex operation that is prone to approximations. Hence, it is worth considering extensions of purely functional approaches that allow the security relevant actions to be quantitatively assessed. This also opens the possibility to balance the application of (expensive) enforcement mechanisms with the security guarantees. With these objectives in view, in this paper we define a probabilistic extension of the Security-by-Contract model, and we show its impact in real-world scenarios through the analysis of several practical Android applications.
Balanced Cluster Head Selection Based on Modified k-Means in a Distributed Wireless Sensor Network

A major problem with Wireless Sensor Networks (WSNs) is the maximization of effective network lifetime through minimization of energy usage in the network nodes. A modified k-means (Mk-means) algorithm for clustering was proposed which includes three cluster heads (simultaneously chosen) for each cluster. These cluster heads (CHs) use a load sharing mechanism to rotate as the active cluster head, which conserves residual energy of the nodes, thereby extending network lifetime. Moreover, it reduces the number of times reclustering has to be done and significantly increases the number of data packets sent during network operation. The results show that Mk-means (modified k-means) algorithm was found to outperform the existing clustering algorithms owing to its unique multiple cluster head methodology.
Audiovisual Speech in Older and Younger Adults: Integrating a Distorted Visual Signal With Speech in Noise

Age-related changes to sensation and cognition may contribute to the differences found between younger and older adults using audiovisual speech. To evaluate this issue, younger and older adults repeated the final word of audio or audiovisual sentences in background noise. Although younger adults performed better than older adults, both age groups demonstrated the same level of visual enhancement in normal audiovisual conditions. However, when the visual speech was blurred, older adults had almost no audiovisual enhancement, whereas younger adults' enhancement was unaffected. These findings are discussed in terms of their implications for audiovisual integration over the course of the life span.
Deriving humanlike arm hand system poses

Robots are rapidly becoming part of our lives, coexisting, interacting, and collaborating with humans in dynamic and unstructured environments. Mapping of human to robot motion has become increasingly important, as human demonstrations are employed in order to “teach” robots how to execute tasks both efficiently and anthropomorphically. Previous mapping approaches utilized complex analytical or numerical methods for the computation of the robot inverse kinematics (IK), without considering the humanlikeness of robot motion. The scope of this work is to synthesize humanlike robot trajectories for robot arm-hand systems with arbitrary kinematics, formulating a constrained optimization scheme with minimal design complexity and specifications (only the robot forward kinematics (FK) are used). In so doing, we capture the actual human arm-hand kinematics, and we employ specific metrics of anthropomorphism, deriving humanlike poses and trajectories for various arm-hand systems (e.g., even for redundant or hyper-redundant robot arms and multifingered robot hands). The proposed mapping scheme exhibits the following characteristics: (1) it achieves an efficient execution of specific human-imposed goals in task-space, and (2) it optimizes anthropomorphism of robot poses, minimizing the structural dissimilarity/distance between the human and the robot arm-hand systems. [DOI: 10.1115/1.4035505]
Tri-band circularly polarized stacked microstrip antenna for GPS and CNSS applications

A compact single-feed stacked microstrip patch antenna for tri-band circularly polarized (CP) application is presented. The proposed antenna with two properly square patches. By inserting two pairs of narrow slots parallel to the edges of the top square patch, with two protruding slots perpendicular to the edge, the top patch can perform CNSS dual-frequency (1.61 GHz and 2.49 GHz) CP radiations using a single probe feed. The GPS frequency (1.57 GHz) is achieved by cutting a slit in the bottom square patch and by adjusting the length of the slit, the antenna can perform CP radiation. Details of the proposed antenna design and results for the obtained tri-band CP performances are presented and discussed.
A site of varicella-zoster virus vulnerability identified by structural studies of neutralizing antibodies bound to the glycoprotein complex gHgL

Significance Mapping neutralizing epitopes on viral entry glycoproteins allows the identification of potentially important functional regions. The structure of varicella-zoster virus (VZV) gHgL bound to two antibodies isolated from immune donors reveals a common binding site. Functional experiments demonstrate that the two antibodies neutralize VZV infection and inhibit glycoprotein gB/glycoprotein complex gHgL-mediated membrane fusion. Immunization experiments in mice demonstrate that VZV gHgL elicits potently neutralizing antibodies and confirm the key role of this antigenic site in antibody-mediated virus neutralization. This manuscript sheds light on the molecular mechanism of herpesvirus cell entry and will guide the design of subunit-based vaccines against VZV. Varicella-zoster virus (VZV), of the family Alphaherpesvirinae, causes varicella in children and young adults, potentially leading to herpes zoster later in life on reactivation from latency. The conserved herpesvirus glycoprotein gB and the heterodimer gHgL mediate virion envelope fusion with cell membranes during virus entry. Naturally occurring neutralizing antibodies against herpesviruses target these entry proteins. To determine the molecular basis for VZV neutralization, crystal structures of gHgL were determined in complex with fragments of antigen binding (Fabs) from two human monoclonal antibodies, IgG-94 and IgG-RC, isolated from seropositive subjects. These structures reveal that the antibodies target the same site, composed of residues from both gH and gL, distinct from two other neutralizing epitopes identified by negative-stain electron microscopy and mutational analysis. Inhibition of gB/gHgL-mediated membrane fusion and structural comparisons with herpesvirus homologs suggest that the IgG-RC/94 epitope is in proximity to the site on VZV gHgL that activates gB. Immunization studies proved that the anti-gHgL IgG-RC/94 epitope is a critical target for antibodies that neutralize VZV. Thus, the gHgL/Fab structures delineate a site of herpesvirus vulnerability targeted by natural immunity.