Miracle-dz/UniFAR-FTUs huggingface dataset:
The Application of Micro-blogging in Ideological and Political Education of College Students

With its unique charm and advantage,micro-blogging is being widely used by college students in communication and by teachers as an important carrier of ideological and political education.What's more,good result has been attained in its application.The paper proposes that micro-blogging be used to collect and spread information,strengthen the interaction between teachers and students,release comments on hot topics,monitor public opinion and launch cultural activities.
Type III secretion system 1 genes in Vibrio parahaemolyticus are positively regulated by ExsA and negatively regulated by ExsD

Vibrio parahaemolyticus harbours two distinct type III secretion systems (T3SS1 and T3SS2). A subset of 10 T3SS1 genes are transcribed when V. parahaemolyticus is grown in tissue culture medium [Dulbecco's modified Eagle's medium (DMEM)], while transcription of these genes (except exsD) is minimal upon growth in Luria–Bertani‐Salt (LB‐S). Transcription of T3SS1 genes and cytotoxicity towards HeLa cells was prevented by deletion of exsA while complementation with exsA restored these traits. Overexpression of ExsA in the wild‐type strain, NY‐4, activated the transcription of T3SS1 genes when bacteria were grown in LB‐S. Thus, ExsA is necessary and sufficient to induce the transcription of T3SS1 genes. Deletion of the exsD permitted the transcription of T3SS1 genes when bacteria were grown in the LB‐S medium and complementation with the wild‐type exsD gene‐blocked transcription of T3SS1 genes. Overexpression of ExsD in NY‐4 prevented the transcription of T3SS1 gene when bacteria were grown in DMEM. A gel mobility shift assay demonstrated that purified ExsA protein binds a novel motif in the upstream region of vp1668 and vp1687, indicating that ExsA interacts directly with the promoter sequences of T3SS1 genes. ExsA positively regulates the expression and secretion of Vp1656 while ExsD negatively regulates the expression and secretion of Vp1656.
User Adoption of Location-based Services

– The purpose of this paper is to investigate the impact of privacy concern on user adoption of location‐based services (LBS). , – Based on the data collected from a survey, structural equation modeling was employed to examine the research model. , – The results indicate that among four dimensions of privacy concern, collection and secondary use are the main factors affecting perceived risk, whereas errors are the main factor affecting trust. Trust affects perceived risk, and both factors determine usage intention. , – Mobile service providers need to alleviate users' privacy concern and perceived risk in order to encourage their adoption and usage of LBS. , – Extant research has mainly examined LBS user behavior from the perspectives of technology acceptance model, task technology fit and unified theory of acceptance and usage of technology. The results provided in this paper indicate that privacy concern also has a significant effect on user adoption of LBS. This advances our understanding of LBS user behavior.
Significantly Reduced Blood Pressure Measurement Variability for Both Normotensive and Hypertensive Subjects: Effect of Polynomial Curve Fitting of Oscillometric Pulses

This study aimed to compare within-subject blood pressure (BP) variabilities from different measurement techniques. Cuff pressures from three repeated BP measurements were obtained from 30 normotensive and 30 hypertensive subjects. Automatic BPs were determined from the pulses with normalised peak amplitude larger than a threshold (0.5 for SBP, 0.7 for DBP, and 1.0 for MAP). They were also determined from cuff pressures associated with the above thresholds on a fitted curve polynomial curve of the oscillometric pulse peaks. Finally, the standard deviation (SD) of three repeats and its coefficient of variability (CV) were compared between the two automatic techniques. For the normotensive group, polynomial curve fitting significantly reduced SD of repeats from 3.6 to 2.5 mmHg for SBP and from 3.7 to 2.1 mmHg for MAP and reduced CV from 3.0% to 2.2% for SBP and from 4.3% to 2.4% for MAP (all P < 0.01). For the hypertensive group, SD of repeats decreased from 6.5 to 5.5 mmHg for SBP and from 6.7 to 4.2 mmHg for MAP, and CV decreased from 4.2% to 3.6% for SBP and from 5.8% to 3.8% for MAP (all P < 0.05). In conclusion, polynomial curve fitting of oscillometric pulses had the ability to reduce automatic BP measurement variability.
Dietary Carbohydrates and Cardiovascular Disease Risk Factors in the Framingham Offspring Cohort

Objective: Evidence from observational studies has suggested that carbohydrate quality rather than absolute intake is associated with greater risk of chronic diseases. The aim of this study was to examine the relationship between carbohydrate intake and dietary glycemic index and several cardiovascular disease risk factors. Methods: We examined cross-sectional associations between total carbohydrate and dietary glycemic index (GI) intakes and several cardiovascular disease risk factors (CVD) in a sample of 2,941 Framingham Offspring Participants. CVD risk factors included waist, blood pressure, lipids, fasting insulin, fasting glucose, and the insulin sensitivity index (ISI0,120). Dietary intake was assessed by a food frequency questionnaire (FFQ) and categorized by quintiles of dietary intake. Results: After adjustment for potential confounding factors, dietary GI was positively associated with fasting triglycerides (mean: 115mg/dL in the lowest and 127 mg/dL in the highest quintile of intake; P for trend < 0.001), fasting insulin (26.8 and 28.9 μu/mL, respectively, P for trend < 0.0001), and inversely associated with HDL cholesterol (49 and 47 mg/dL, respectively, P for trend 0.003) and ISI0,120 (26.8 and 25.1, P for trend < 0.001). There was no significant relationship between dietary GI and waist circumference, total cholesterol, LDL cholesterol and fasting glucose. Intakes of total carbohydrate were inversely associated with waist circumference and HDL cholesterol, and positively associated with fasting triglycerides. Conclusion: These cross-sectional findings support the hypothesis that a high GI diet unfavorably affects CVD risk factors and therefore, substitution of high with low GI dietary carbohydrates may have reduce the risk of CVD.
Enhanced ISAR Imaging and Motion Estimation With Parametric and Dynamic Sparse Bayesian Learning

This paper is focused on high-resolution inverse synthetic aperture radar (ISAR) imaging and motion estimation of maneuvering targets from compressively sampled echo data. Herein, a local structural sparse Bayesian learning (LS-SBL) algorithm is proposed by exploiting the joint sparsity pattern of adjacent scatterers. A structured prior by modeling the neighboring correlation or dependence is utilized to encode the joint sparsity pattern. Meanwhile, a parametric dictionary with unknown rotational parameters is constructed to represent the target maneuverability. The solution to the LS-SBL algorithm is decomposed into iterations between sparse imaging and dictionary learning. In sparse imaging, an expectation-maximization method is employed for ISAR image formation and hyperparameter estimation by using a predesigned dictionary. In dictionary learning, an efficient approach of rotational parameter estimation is presented to dynamically update the parametric dictionary. Due to the exploitation of joint sparsity pattern, enhanced performance of ISAR image reconstruction can be achieved by effectively preserving the target structure. In addition, the cross-range scaled ISAR image is obtainable by extracting the target geometry, which benefits from the rotational motion estimation. Finally, experiments on simulated and measured data demonstrate the effectiveness of the proposed algorithm.
Evaluation of an Interactive Visualization Tool for the Interpretation of Pediatric Laboratory Test Results

The physiological age-related development of pediatric laboratory results interferes with pathological derangements, which can complicate the interpretation of test results. Recently proposed continuous reference intervals (RIs) promise to be beneficial, although their clinical use may depend on graphical presentations. To estimate the clinical utility of continuous RIs, we developed and evaluated an interactive visualization tool, and examined the differentiation of hemoglobinopathies that is attainable based on the underlying innovative RI model. The implemented web application allows users to easily enter laboratory test results, and displays various visualizations in conjunction with the corresponding RIs, such as charts and personalized Z-scores. To evaluate the usability of the visualization tool, we conducted concurrent think-aloud sessions with four physicians, who were prompted to solve a set of typical interpretation tasks, and acquired additional information through a questionnaire including the System Usability Scale (SUS). We used 85 de-identified clinical cases for an exemplified assessment of how well model-based interpretations of blood count parameters reproduced previously diagnosed hemoglobinopathies. Usability tests as well as questionnaire responses indicated that the developed tool was well received by the physicians. Results from the think-aloud evaluation revealed only minor problems and the tool reached an average SUS score of 86.9, suggesting good usability. Hemoglobinopathy discrimination depended on the considered subtype, although the overall performance of the novel method rivaled the one of the conventional approach. The interactive visualization of innovative continuous reference intervals demonstrated promising results, which justifies further testing on the path towards clinical routine.
Short-term Cardiorespiratory Effects of Proportional Assist and Pressure-support Ventilation in Patients with Acute Lung Injury/Acute Respiratory Distress Syndrome

Background: Recent data indicate that assisted modes of mechanical ventilation improve pulmonary gas exchange in patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Proportional assist ventilation (PAV) is a new mode of support that amplifies the ventilatory output of the patient effort and improves patient–ventilator synchrony. It is not known whether this mode may be used in patients with ALI/ARDS. The aim of this study was to compare the effects of PAV and pressure-support ventilation on breathing pattern, hemodynamics, and gas exchange in a homogenous group of patients with ALI/ARDS due to sepsis. Methods: Twelve mechanically ventilated patients with ALI/ARDS (mean ratio of partial pressure of arterial oxygen to fractional concentration of oxygen 190 ± 49 mmHg) were prospectively studied. Patients received pressure-support ventilation and PAV in random order for 30 min while maintaining mean airway pressure constant. With both modes, the level of applied positive end-expiratory pressure (7.1 ± 2.1 cm H2O) was kept unchanged throughout. At the end of each study period, cardiorespiratory data were obtained, and dead space to tidal volume ratio was measured. Results: With both modes, none of the patients exhibited clinical signs of distress. With PAV, breathing frequency and cardiac index were slightly but significantly higher than the corresponding values with pressure-support ventilation (24.5 ± 6.9 vs. 21.4 ± 6.9 breaths/min and 4.4 ± 1.6 vs. 4.1 ± 1.3 l · min−1 · m−2, respectively). None of the other parameters differ significantly between modes. Conclusions: In patients with ALI/ARDS due to sepsis, PAV and pressure-support ventilation both have clinically comparable short-term effects on gas exchange and hemodynamics.
Local Recurrence and Its Risk Factor after Incomplete Resection of Colorectal Advanced Adenomas: A Single Center, Retrospective Study.

Background/Aims Colonoscopy can detect precancerous lesions, which can subsequently be removed and reduce incidences of and mortality from colorectal cancer (CRC). However, recently published data have highlighted a significant rate of CRC in patients who previously underwent colonoscopy. Among many reasons, incomplete resection has been considered as a significant contributor. However, to date, there have only been a few studies regarding incompletely resected polyps, especially advanced colorectal adenoma (ACA). Hence, we aimed to evaluate the prognosis of incompletely resected ACA. Methods We retrospectively reviewed the medical records of patients with ACA who had underwent endoscopic treatment with incomplete resection. The primary outcomes were (1) the incomplete resection rate of ACA, as determined by a histopathologic examination and (2) the recurrence rate of incompletely resected ACA. We also investigated the probable contributing factors that may have led to a relapse of incompletely resected ACA. Results A total of 7,105 patients had their colorectal polyps resected by endoscopic treatment, and 2,233 of these were considered as ACA. Of these, 354 polyps (15.8%) were resected incompletely, and only 163 patients were followed-up. Of those followed-up, 31 patients (19.0%) experienced local recurrence. The risk factors for recurrence after incomplete resection were evaluated; age, morphology of adenoma, and use of rescue therapy, such as argon plasma coagulation, were found to be associated with adenoma recurrence. Conclusions Incompletely resected ACA in older patients or in patients with sessile-type adenomas should be monitored strictly, and if incomplete resection is suspected, rescue therapy must be considered.
Outsourcing privacy-preserving social networks to a cloud

In the real world, companies would publish social networks to a third party, e.g., a cloud service provider, for marketing reasons. Preserving privacy when publishing social network data becomes an important issue. In this paper, we identify a novel type of privacy attack, termed 1*-neighborhood attack. We assume that an attacker has knowledge about the degrees of a target's one-hop neighbors, in addition to the target's 1-neighborhood graph, which consists of the one-hop neighbors of the target and the relationships among these neighbors. With this information, an attacker may re-identify the target from a k-anonymity social network with a probability higher than 1/k, where any node's 1-neighborhood graph is isomorphic with k - 1 other nodes' graphs. To resist the 1*-neighborhood attack, we define a key privacy property, probability indistinguishability, for an outsourced social network, and propose a heuristic indistinguishable group anonymization (HIGA) scheme to generate an anonymized social network with this privacy property. The empirical study indicates that the anonymized social networks can still be used to answer aggregate queries with high accuracy.
Need For Cognition and Attitude Persistence

The attitudes of individuals exposed to a television advertisement were assessed immediately after viewing and two days later. Based on predictions derived from the Elaboration Likelihood Model, it was predicted the attitudes of individuals scoring high in need for cognition would be more persistent over time than would quantitatively similar attitudes formed by individuals scoring low in need for cognition. Theoretical and applied implications for the study of attitude persistence are discussed.
P-Glycoprotein Function at the Blood–Brain Barrier Imaged Using 11C-N-Desmethyl-Loperamide in Monkeys

11C-Loperamide is an avid substrate for P-glycoprotein (P-gp), but it is rapidly metabolized to 11C-N-desmethyl-loperamide (11C-dLop), which is also a substrate for P-gp and thereby contaminates the radioactive signal in the brain. Should further demethylation of 11C-dLop occur, radiometabolites with low entry into the brain are generated. Therefore, we evaluated the ability of 11C-dLop to quantify the function of P-gp at the blood–brain barrier in monkeys. Methods: Six monkeys underwent 12 PET scans of the brain, 5 at baseline and 7 after pharmacologic blockade of P-gp. A subset of monkeys also underwent PET scans with 15O-water to measure cerebral blood flow. To determine whether P-gp blockade affected peripheral distribution of 11C-dLop, we measured whole-body biodistribution in 4 monkeys at baseline and after P-gp blockade. Results: The concentration of 11C-dLop in the brain was low under baseline conditions and increased 5-fold after P-gp blockade. This increase was primarily caused by an increased rate of entry into the brain rather than a decreased rate of removal from the brain. With P-gp blockade, uptake of radioactivity among brain regions correlated linearly with blood flow, suggesting a high single-pass extraction. After correction for cerebral blood flow, the uptake of 11C-dLop was fairly uniform among brain regions, suggesting that the function of P-gp is fairly uniformly distributed in the brain. On whole-body imaging, P-gp blockade significantly affected distribution of radioactivity only to the brain and not to other visually identified source organs. The effective dose estimated for humans was approximately 9 μSv/MBq. Conclusion: PET with 11C-dLop can quantify P-gp function at the blood–brain barrier in monkeys. The single-pass extraction of 11C-dLop is high and requires correction for blood flow to accurately measure the function of this efflux transporter. The low uptake at baseline and markedly increased uptake after P-gp blockade suggest that 11C-dLop will be useful to measure a wide range of P-gp functions at the blood–brain barrier in humans.
Assessment of regional systolic and diastolic dysfunction in familial hypertrophic cardiomyopathy using MR tagging

Diastolic and systolic left ventricular (LV) dysfunction often significantly contribute to disabling symptoms in familial hypertrophic cardiomyopathy (FHC). This study compares regional LV function (midwall circumferential strain) during systole and diastole in eight FHC patients and six normal volunteers (NVs) using MR tagging. A prospectively‐gated fast gradient‐echo sequence with an echo‐train readout was modified to support complementary spatial modulation of magnetization (CSPAMM) tagging and full cardiac cycle data acquisition using the cardiac phase to order reconstruction (CAPTOR), thus providing tag persistence and data acquisition during the entire cardiac cycle. Total systolic strains in FHC patients were significantly reduced in septal and inferior regions (both P < 0.01). Early‐diastolic strain rates were reduced in all regions of the FHC group (all P < 0.03). The combination of CSPAMM and CAPTOR allows regional indices of myocardial function to be quantified throughout the cardiac cycle. This technique reveals regional differences in systolic and diastolic impairment in FHC patients. Magn Reson Med 50:638–642, 2003. Published 2003 Wiley‐Liss, Inc.
Comparison of Perceived Exertion Ratings during Graded Peak Cycle Exercise between Cigarette Smokers and Nonsmokers

This study compared differentiated Ratings of Perceived Exertion (RPE) for the chest (RPE-Chest) and legs (RPE-Legs) and undifferentiated ratings (RPE-Overall) between cigarette smokers (n = 10) and nonsmokers (n = 10) during graded, peak cycle exercise. Linear regression analyses expressed RPE-Chest, RPE-Leg, and RPE-Overall as a function of VO2 for smokers and nonsmokers. RPE equivalent to 50, 70, and 90% VO2peak were compared between. Chest, Leg, and Overall RPE were similar at each % VO2peak. In the combined smokers and nonsmokers, RPE-Chest was lower (p<.05) than the RPE-Overall at each % VO2peak. RPE-Leg did not differ from RPE-Overall at 50% VO2peak, but was higher (p<.05) at 70% and 90% VO2peak. These results validate Assumption 4 for application of the Borg 15-category scale in that this assumption is also valid for differentiated RPE. Smoking did not influence the intensity of differentiated or undifferentiated RPE during graded cycle exercise.
Safety and Immunogenicity of a Gag-Pol Candidate HIV-1 DNA Vaccine Administered by a Needle-Free Device in HIV-1-Seronegative Subjects

Objective:To evaluate the safety and immunogenicity of a candidate HIV DNA vaccine administered using a needle-free device. Design:In this phase 1, dose escalation, double-blind, placebo-controlled clinical trial, 21 healthy adults were randomized to receive placebo or 0.5, 1.5, or 4 mg of a single plasmid expressing a Gag/Pol fusion protein. Each participant received repeat immunizations at days 28 and 56 after the first inoculation. Safety and immunogenicity data were collected. Results:The vaccine was well tolerated, with most adverse events being mild injection site reactions, including pain, tenderness, and erythema. No dose-limiting toxicities occurred. HIV-specific antibody response was not detected in any vaccinee by enzyme-linked immunosorbent assay. HIV-specific T-cell responses to Gag or Pol as measured by enzyme-linked immunospot assay and intracellular cytokine staining were of low frequency and magnitude. Conclusions:This candidate HIV DNA vaccine was safe and well tolerated. No HIV-specific antibody responses were detected, and only low-magnitude HIV-specific T-cell responses were detected in 8 (53%) of 15 vaccinees. This initial product led to the development of a 4-plasmid multiclade HIV DNA Vaccine Research Center vaccine candidate in which envelope genes expressing Env from clades A, B, and C and a Nef gene from clade B have been added.
A fault tolerant dynamically scheduled processor with partial permanent fault handling

This paper describes architectural extensions for a dynamically scheduled processor, in order to make it almost completely fault-tolerant against single event upsets. The base architecture is a Tomasulo architecture, whose sphere of replication covers the most relevant data path elements, in order to protect them from temporary and permanent faults by concurrent execution. Nevertheless, some critical signals of the data path and all components outside the data path remain still sensitive to faults. For that reason an additional recovery mechanism was implemented that causes a re-execution of already fetched instructions, if errors are detected in the critical signals and components outside the sphere of replication. We describe how to extend these components with simple error detection techniques that can trigger the recovery mechanism. It turned out that with that combination the processor can be protected against almost all transient faults by only 20 % hardware overhead according to the used fault model. Furthermore we investigate the robustness of the approach against permanent faults.