Miracle-dz/UniFAR-FTUs huggingface dataset:
283 Localized (cid:2) uncaging reveals polarized distribution of Ca 2 (cid:2) -sensitive Ca 2 (cid:2) release sites: mechanism of unidirectional Ca 2 (cid:2)

UK a 2 (cid:2) -induced Ca 2 (cid:2) release (CICR) plays an important role in the generation of cytosolic Ca 2 (cid:2) signals in many cell types. However, it is inherently difﬁcult to distinguish experimentally between the contributions of messenger-induced Ca 2 (cid:2) release and CICR. We have directly tested the CICR sensitivity of different regions of intact pancreatic acinar cells using local uncaging of caged Ca 2 (cid:2) . In the apical region, local uncaging of Ca 2 (cid:2) was able to trigger a CICR wave, which propagated toward the base. CICR could not be triggered in the basal region, despite the known presence of ryanodine receptors. The triggering of C from the apical region was inhibited by a pharmacological block of ryanodine or inositol trisphosphate receptors, indicating that global signals require coordinated Ca 2 (cid:2) release. Subthreshold agonist stimulation increased the probability of triggering CICR by apical uncaging, and uncaging-induced CICR could activate long-lasting Ca 2 (cid:2) oscillations. However, with subthreshold stimulation, CICR could still not be initiated in the basal region.
Extracurricular activity and parental involvement predict positive outcomes in elementary school children

The main goal of this study was to explore if parental involvement and extracurricular activity participation could predict well‐being and academic competence in elementary school children. Seventy‐two children (mean age = 10.9 years, SD = 0.85) and their parents participated. Results revealed that parental pressure and support, when paired with extracurricular activity participation, successfully predicted children’s well‐being and academic competence. Follow‐up analyses were conducted to establish differences between children who participate in low versus high numbers of activities. Results are discussed in terms of how extracurricular activities and parental involvement in activities impact upon positive outcomes in childhood.
Talking about STD/HIV prevention: a look at communication online

Little is known about the quality and usability of online health information. This analysis evaluated STD prevention websites’ content quality and usability. Thirty-six sites were analyzed to determine their adherence to established sexual health guidelines and their accessibility, usability, credibility and currency. The objective of this study was to determine what communication skills are available to teenagers through STD prevention websites. Only two (6%) addressed safe sex negotiation; seven (19%) addressed basic communication skills; and slightly more than half (53%) addressed at least one sexual decision-making message. Most sites displayed consistent template design and two-thirds had working hyperlinks. But few (19%) of the sites offered a site map, while only one-third (36%) provided an internal search engine. These results indicate that health educators need to include tips on how to negotiate safe sex and improve interactive design features when creating STD websites for teenagers.
Accurate Spectral Energy Distributions and Selection Effects for High-Redshift Dusty Galaxies: A New Hot Population to Discover with the Spitzer Space Telescope?

The spectral energy distributions (SEDs) of dust-enshrouded galaxies with powerful rest-frame far-infrared emission have been constrained by a range of ground-based and space-borne surveys. The IRAS catalog provides a reasonably complete picture of the dust emission from nearby galaxies (redshift z ≃ 0.1) that are typically less luminous than about 1012 L☉. However, at higher redshifts, the observational coverage from all existing far-IR and submillimeter surveys is much less complete. Here we investigate the SEDs of a new sample of high-redshift submillimeter-selected galaxies (SMGs) for which redshifts are known, allowing us to estimate reliable luminosities and characteristic dust temperatures. We demonstrate that a wide range of SEDs is present in the population, and that a substantial number of luminous dusty galaxies with hotter dust temperatures could exist at similar redshifts (z ≃ 2-3), but remain undetected in existing submillimeter surveys. These hotter galaxies could be responsible for about a third of the extragalactic IR background radiation at a wavelength of about 100 μm. The brightest of these galaxies would have far-IR luminosities of the order of 1013 L☉ and dust temperatures of the order of 60 K. Galaxies up to an order of magnitude less luminous with similar SEDs will be easy to detect and identify in the deepest Spitzer Space Telescope observations of extragalactic fields at 24 μm.
5.65 GHz High-Efficiency GaN HEMT Power Amplifier With Harmonics Treatment up to Fourth Order

A high-efficiency GaN HEMT power amplifier with harmonics treatment up to the fourth order has been developed at the 5.8 GHz band. The harmonics treatment was applied by considering the influence of feedback and shunt capacitance in the GaN HEMT, to reduce the average power consumption in a GaN HEMT including parasitic elements. The fabricated GaN HEMT amplifier delivered a maximum power-added efficiency of 79% and a maximum drain efficiency of 90% at 5.65 GHz, and the saturated output power was 33.3 dBm. This value represents state-of-the-art C-band performance efficiency.
Preliminary data on abuse during childhood among female university students

This study investigated the childhood experiences of physical and sexual abuse in relation to the risk of adult depression among female university students. The objectives of the study were to determine the prevalence of abusive experiences in childhood, to examine if childhood physical and sexual abuse, parental antipathy and neglect correlated to depression, and to determine the risk factors of depression in this population. A translated childhood experience of care and abuse questionnaire (CECA-Q) was randomly distributed to the students. The results showed that the reliability of the CECA-Q was good and stable. The prevalent rate of childhood physical abuse in this population was 19% and childhood sexual abuse was 5%. Childhood physical abuse by the mother was a significant risk factor in contributing to depression. The study provides evidence of a correlation between childhood abuse and depression among female university students.
Organizational alignment: A model to explain the relationships between organizational relevant variables

Purpose – The purpose of this paper is to propose a theoretical model for the in‐depth study of organizations, producing a framework which makes it possible to clarify many propositions and to specifically test the theory. In order to carry out this assignment, the paper has two sub‐objectives. Design/methodology/approach – The first one studies the adaptation of the internal culture‐structure variables as a way to determine the congruity of the components of the companies which form the real structure and to study the behavior that is expected from the people in the organization. The second sub‐aim is to analyze whether the partial adaptations of real structure mentioned above are orientated correctly towards the achievement of the strategic aims. Only a suitable design of the real structure which in turn enables the attainment of the aims raised by the strategy will give rise to the obtaining of a suitable level of efficiency. Findings – The key contribution of the paper is to render operative in practical terms such a diffuse concept as is the alignment model. Originality/value – Alignment theory has been combined with configuration theory to detect the ideal cultural, structural, and strategic options and making the comparison with the real forms possible in order to analyze the possible deviations and to predict the level of efficiency.
Self-Complexity as a Potential Cognitive Buffer Among Abused Women

Abstract Low self-esteem and depression are common among domestic violence victims (e.g., Orava, McLeod, & Sharpe, 1996). Physical and verbal abuse may reinforce victims' sense of helplessness by stripping away their real social roles. Linville (1985, 1987) hypothesized that individuals who maintain high self-complexity (i.e., many roles within their self-concept and little overlap among them) are buffered against affective reactions to stressful events. Using Linville's measure, we investigated self-complexity among abused and nonabused women in a cross-sectional design. Given the restrictive nature of domestic violence, we predicted a negative relationship between abuse (physical and verbal) and self-complexity. We also hypothesized that abused women with high self-complexity would show greater self-esteem and lower levels of depression. Our findings show a negative relationship between amount of physical violence and self-complexity, and are consistent with a buffering effect of high self-complexity fo.
Primitive Intervals versus Point-Based Intervals: Rivals or Allies?

The notion of time is a very interesting and exciting subject both in science and everyday life. One of the fundamental questions is: what is time composed of? While the traditional time structure is based on a set of points, a notion that has been prevalently adopted in classical physics and mathematics, it has also been noticed that intervals have been widely adopted for expression of commonsense temporal knowledge, especially in the domain of artificial intelligence. However, there has been a long-standing debate on whether intervals should be treated as primitive or not, leading to two different approaches to the treatment of intervals. In the first, intervals are modelled as derived objects constructed from points, e.g. sets of points, or pairs of points. In the second, intervals are taken as primitive themselves. This article provides a critical examination of these two approaches. By means of proposing a definition of intervals in terms of points and types, we shall demonstrate that, while the two different approaches have been viewed as rivals in the literature, they are actually reducible to logically equivalent expressions under some requisite interpretations, and therefore they can also be viewed as allies.
Biogenesis of membrane-bound and secreted immunoglobulins. II. Two forms of the human alpha chain translated in vitro and processed in vivo as distinct polypeptide chains

Structural differences between alpha m (ther heavy chain of membrane IgA) and alpha s (the heavy chain of secretory IgA) were investigated. Messenger RNA from the human B lymphoblastoid line 32a.1, expressing both membrane and secretory IgA, was translated in a wheat germ cell- free system, resulting in the synthesis of two primary translation products for the alpha chain, that differed in molecular weight. In vivo pulse and pulse-chase experiments demonstrated that two early biosynthetic forms of the alpha chain were subsequently modified to yield three intracellular forms. As shown by endo-beta-N- acetylglucosaminidase H (endo H) treatment, these forms represent two alpha polypeptide chains, with varying compositions of N-linked oligosaccharides. Of the two forms of the alpha chain remaining after endo H treatment, only the form with the lowest molecular weight was associated with cells after long chase periods. The possible significance of this difference from the results with mu and delta chains is discussed. These results indicate that alpha m is distinguished from an alpha s by a difference in both primary structure and intracellular processing. The functional consequences of this distinction, previously shown for the heavy chain of membrane IgM (micrometer) and heavy chain of secretory IgM (microseconds), may reflect a principle common to the secretory and membrane forms of all immunoglobulin heavy chain classes.
Labor Surplus and Punishment: A Review and Assessment of Theory and Evidence

Since the pioneering work ofRusche and Kirchheimer (1939), the theoretical links between labor surplus and punishment have seen extensive development. Eleven of those links described here are mediated by economic, political, and ideological factors such as the value of labor, the systemic needs of capitalism, and the ideology of judges and their communities. The sophistication of theorizing about labor surplus and punishment is matched with skepticism about the corresponding empirical evidence which has been termed “elusive”and “contradictory” at best. The results from 44 empirical studies are systematically assessed. The evidence suggests that independent of the effects of crime, labor surplus is consistently and significantly related to prison population, and to prison admissions when time-series and individual level data are used. The relationship of labor surplus and punishment appears slightly stronger when age, race, and gender specific measures are employed. The limitations of existing research, in light of theoretical developments, are discussed.
Innateness and culture in the evolution of language

Human language arises from biological evolution, individual learning, and cultural transmission, but the interaction of these three processes has not been widely studied. We set out a formal framework for analyzing cultural transmission, which allows us to investigate how innate learning biases are related to universal properties of language. We show that cultural transmission can magnify weak biases into strong linguistic universals, undermining one of the arguments for strong innate constraints on language learning. As a consequence, the strength of innate biases can be shielded from natural selection, allowing these genes to drift. Furthermore, even when there is no natural selection, cultural transmission can produce apparent adaptations. Cultural transmission thus provides an alternative to traditional nativist and adaptationist explanations for the properties of human languages.
Preparation and Characterization of Extruded Composites Based on Polypropylene and Chitosan Compatibilized with Polypropylene-Graft-Maleic Anhydride

The preparation of composites of synthetic and natural polymers represent an interesting option to combine properties; in this manner, polypropylene and chitosan extruded films using a different proportion of components and polypropylene-graft-maleic anhydride (PPgMA) as compatibilizer were prepared. The effect of the content of the biopolymer in the polypropylene (PP) matrix, the addition of compatibilizer, and the particle size on the properties of the composites was analyzed using characterization by fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), tensile strength, and contact angle, finding that in general, the addition of the compatibilizer and reducing the particle size of the chitosan, favored the physicochemical and morphological properties of the films.
Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum

Nanomedicine has recently emerged as a better option for the treatment of various diseases. Here, we investigated the in vivo anticoccidial properties of zinc oxide nanoparticles (ZNPs). ZNPs were crystalline in nature, with a smooth and spherical surface and a diameter in the range of ~10–15 nm. The X-ray diffraction pattern was utilized to identify the crystalline property of the grown ZNPs, whereas field emission scanning electron microscopy was employed to check the size and morphology of the ZNPs. The data showed that mice infected with Eimeria papillata produced 29.7×103±1,500 oocysts/g feces on day 5 postinfection. This output was significantly decreased, to 12.5×103±1,000 oocysts, in mice treated with ZNPs. Infection also induced inflammation and injury of the jejunum. This was evidenced (1) through an increase in the inflammatory histological score, (2) through increased production of nitric oxide and malondialdehyde, and (3) through a decrease in both the glutathione level and goblet cell number in mice jejuna. All these infection-induced parameters were significantly altered during treatment with ZNPs. Our results indicate, therefore, that ZNPs have protective effects against E. papillata-induced coccidiosis.
The Relationship Between Deployment and Turnover in Australian Navy Personnel

Increases in the frequency of operations tempo have focused attention on the relationship between deployment and separation from military service. This retrospective study explored the association between deployment and turnover over a 10-year period in Royal Australian Navy (RAN) personnel. Participants were 2355 males who served in the RAN during the period of the 1991 Gulf War (August 1990–September 1991); approximately half had been deployed to that conflict. Data were collected 10 years later as part of the Australian Gulf War Veterans' Health Study. During that 10-year period, 61% of participants left the RAN. The likelihood of separation decreased as number of deployments increased even when controlling for age, rank, and length of service. Personnel deployed to the 1991 Gulf conflict did not have a significantly higher risk of separation. The results provide evidence that deployment is not necessarily a risk factor for separation.
Usability remote evaluation for WWW

In the last few years many remote methods have been proposed for usability evaluation. For evaluation of WWW interfaces, remote methods present some advantages over traditional ones. In general, they are cheaper and faster than the traditional ones due to the fact that neither users nor evaluators need to move to take part in the tests. However, they fail to provide more accurate data for usability analysis. This paper presents a faster and low cost method for WWW evaluation that provides better data for analysis. The novelty of this method is due to the merging of tracking of users' actions and subjective information provided through questionnaires in the same evaluation tool.
In silico Platform for Prediction of N-, O- and C-Glycosites in Eukaryotic Protein Sequences

Glycosylation is one of the most abundant and an important post-translational modification of proteins. Glycosylated proteins (glycoproteins) are involved in various cellular biological functions like protein folding, cell-cell interactions, cell recognition and host-pathogen interactions. A large number of eukaryotic glycoproteins also have therapeutic and potential technology applications. Therefore, characterization and analysis of glycosites (glycosylated residues) in these proteins is of great interest to biologists. In order to cater these needs a number of in silico tools have been developed over the years, however, a need to get even better prediction tools remains. Therefore, in this study we have developed a new webserver GlycoEP for more accurate prediction of N-linked, O-linked and C-linked glycosites in eukaryotic glycoproteins using two larger datasets, namely, standard and advanced datasets. In case of standard datasets no two glycosylated proteins are more similar than 40%; advanced datasets are highly non-redundant where no two glycosites’ patterns (as defined in methods) have more than 60% similarity. Further, based on our results with several algorihtms developed using different machine-learning techniques, we found Support Vector Machine (SVM) as optimum tool to develop glycosite prediction models. Accordingly, using our more stringent and non-redundant advanced datasets, the SVM based models developed in this study achieved a prediction accuracy of 84.26%, 86.87% and 91.43% with corresponding MCC of 0.54, 0.20 and 0.78, for N-, O- and C-linked glycosites, respectively. The best performing models trained on advanced datasets were then implemented as a user-friendly web server GlycoEP (http://www.imtech.res.in/raghava/glycoep/). Additionally, this server provides prediction models developed on standard datasets and allows users to scan sequons in input protein sequences.
A longitudinal study of programmers' backtracking

Programming often involves reverting source code to an earlier state, which we call backtracking. We performed a longitudinal study of programmers' backtracking, analyzing 1,460 hours of fine-grained code editing logs collected from 21 people. Our analysis method keeps track of the change history of each abstract syntax tree node and looks for backtracking instances within each node. Using this method, we detected a total of 15,095 backtracking instances, which gives an average backtracking rate of 10.3/hour. The size of backtracking varied con-siderably, ranging from a single character to thousands of char-acters. 34% of the backtracking was performed by manually deleting or typing the desired code, and 9.5% of all backtracking was selective, meaning that it could not have been performed using the conventional undo command present in the IDE. The study results show that programmers need better backtracking tools, and also provide design implications for such tools.
Continuous Subgraph Pattern Search over Graph Streams

Search over graph databases has attracted much attention recently due to its usefulness in many fields, such as the analysis of chemical compounds, intrusion detection in network traffic data, and pattern matching over users' visiting logs. However, most of the existing work focuses on search over static graph databases while in many real applications graphs are changing over time. In this paper we investigate a new problem on continuous subgraph pattern search under the situation where multiple target graphs are constantly changing in a stream style, namely the subgraph pattern search over graph streams. Obviously the proposed problem is a continuous join between query patterns and graph streams where the join predicate is the existence of subgraph isomorphism. Due to the NP-completeness of subgraph isomorphism checking, to achieve the real time monitoring of the existence of certain subgraph patterns, we would like to avoid using subgraph isomorphism verification to find the exact query-stream subgraph isomorphic pairs but to offer an approximate answer that could report all probable pairs without missing any of the actual answer pairs. In this paper we propose a light-weight yet effective feature structure called Node-Neighbor Tree to filter false candidate query-stream pairs. To reduce the computational cost, we further project the feature structures into a numerical vector space and conduct dominant relationship checking in the projected space. We propose two methods to efficiently check dominant relationships and substantiate our methods with extensive experiments.
Performance Analysis of Adjusted Counter Based Broadcasting in Mobile Ad Hoc Networks

Mobile Ad Hoc Network (MANET) is a reliable system formed by co-operating and independent nodes that connect and communicate with each other wirelessly without pre-existing infrastructure. In such a network, the easiest way to broadcast the packets to all network nodes is flooding. However, flooding leads to serious drawbacks such as collision, contention and redundant retransmission. These drawbacks are known as the broadcast storm problem. This research proposes an adaptive algorithm in order to decrease the overall network overhead and minimize the problems associated to flooding. Moreover this research concentrates on studying the effect of using different mobility models that provide general idea about nodes movement, status and locations. In particular the performance of Random Waypoint and File mobility models in terms of their effect on network communication is evaluated. Moreover, this research provides performance evaluation of different traffic types such as Constant Bit Rate (CBR) and Traffic GEN. Results from Qualnet simulations have revealed that the new proposed algorithm outperforms flooding in terms of different metrics: reducing end-to-end delay in addition to minimizing the normalized routing load and maximizing the packets delivery ratio, in addition to concluding that Traffic GEN outperforms the CBR in terms of throughput. Moreover the CBR traffic has higher delay values than Traffic GEN.