Miracle-dz/UniFAR-FTUs huggingface dataset:
Designing Clustered Multiprocessor Systems under Packaging and Technological Advancements

Clustered or hierarchical interconnections have advantages when designing large scale multiprocessor systems. Earlier studies have either focused on only flat interconnections or proposed hierarchical/clustered interconnections with limited packaging and demanded performance constraints. Large systems require several levels of packaging. Packaging technologies impose various physical constraints on bisection bandwidth and channel width of a system. Pinout technologies and the capacity of packaging modules have been ignored in earlier studies, often leading to configurations that are not design-feasible. Similarly, the impact of processor and interconnect technologies on demanded performance has not been considered. We propose a new supply-demand framework for multiprocessor system design by considering packaging, processor, and interconnect technologies in an integrated manner. The elegance of this framework lies in its parameterised representation of different technologies. For a given set of technological parameters the framework derives the best configuration while considering practical design aspects like maximum board area, maximum available pinout, fixed channel width, and scalability. In order to build a scalable parallel system with a given number of processors, the framework explores the design space of flat k-ary n-cube topologies and their clustered variations (k-ary n-cube cluster-c) to derive design-feasible configurations with best system performance.
Two Target Regions of Allelic Loss on Chromosome 9 in Urinary‐bladder Cancer

Allelic losses on chromosome 9 are common in a wide variety of human tumors; moreover, two predisposing loci for some inherited cancer syndromes, i.e., familial malignant melanoma and Gorlin syndrome, have been identified on this chromosome. To define the location of putative tumor suppressor genes involved in cancer of the urinary bladder, 85 bladder cancers were examined for allelic loss at 18 microsatellite loci on chromosome 9. Correlations were also sought between loss of heterozygosity on chromosome 9 and several clinicopathological parameters. Allelic loss was observed in 54 of the tumors (64%) and deletion mapping identified two target regions; one at an interval on 9p21 flanked by D9S736 and D9S165, and the other at an interval on 9q31‐34 flanked by D9S58 and D9S61. No subtle mutation was detected in the PTCH gene which lies in the latter interval. Allelic loss on chromosome 9 was observed frequently in low grade and non‐invasive tumors as well as in tumors of more advanced phenotype. Inactivation of tumor suppressor genes lying in either of two regions of common deletion identified on chromosome 9 might affect carcinogenic mechanisms at an early stage of tumor development in the urinary bladder.
Extension of a Non-Linear, Two-Step Calibration Methodology to Include Non-Orthogonal Sensor Axes

We present an extension of the non-linear two-step estimation algorithm originally developed for the calibration of solid-state strapdown magnetometers. We expand the algorithm to include nonorthogonality within a sensor set for both two and three axis sensors. Non-orthogonality can result from manufacturing issues, installation geometry, and in the case of magnetometers, soft iron bias errors. Simulation studies for both two and three-axis sensors show convergence of the improved algorithm to the true values, even in the presence of realistic measurement noise. Finally the algorithm is experimentally validated on a low-cost solid state three-axis magnetometer set, which shows definite improvement post-calibration. We note that the algorithm is general and can be applied to any two or three-axis sensor set with an error model consisting of scale, offset, and non-orthogonality errors.
Constraint satisfaction modules: a methodology for analog circuit design

This dissertation describes a methodology for solving convex constraint problems using analog circuits. It demonstrates how this methodology can be used to design circuits that solve function-fitting problems through iterated gradient descent. In particular, it shows how to build a small circuit that can model a nonlinearity by observation, and predistort to compensate for this nonlinearity. The system fits into a broader effort to investigate non-traditional approaches to circuit design. First, it breaks the traditional input-output abstraction barrier; all ports are bidirectional. Second, it uses a different methodology for proving system stability with local rather than global properties. Such stability arguments can be scaled to much more complex systems than traditional stability criteria. Thesis Supervisor: Gerald Jay Sussman Title: Panasonic Professor of Electrical Engineering Thesis Supervisor: Thomas F. Knight, Jr Title: Senior Research Scientist
The World-Wide Web as a Super-Brain: from metaphor to model

ticular has been characterized by the explosive development of many-to-many communication networks. Whereas the traditional communication media link sender and receiver directly, networked media have multiple crossconnections between the different channels, allowing complex sets of data from different sources to be integrated before being delivered to the receivers. For example, a newsgroup discussion on the Internet will have many active contributors as well as many people just ‘listening in’. Moreover, the fact that the different ‘nodes’ of the digital network are controlled by computers allows sophisticated processing of the collected data, reinforcing the similarity between the network and the brain. This has led to the metaphor of the world-wide computer network as a ‘global brain’ [Mayer-Kress & Barczys, 1995; Russell, 1995]. If society is viewed as a super-organism, communication networks play the role of its brain. This metaphor is developed into a model for the design of a more intelligent global network. The WorldWide Web, through its distributed hypermedia architecture, functions as an “associative memory”, which may “learn” by the strengthening of frequently used links. Software agents, exploring the Web through spreading activation, function as problem-solving “thoughts”. Users are integrated into this "super-brain" through direct manmachine interfaces and the reciprocal exchange of knowledge between individual and Web.
Effect of Administration of Garlic Extract and PGF2慣 on Hormonal Changes and Recovery in Endometritis Cows

The efficacy of garlic extract and PGF 2 α in the treatment of endometritis in cows was evaluated. A total of 26 parous cows affected with endometritis were randomly allocated into three groups. Group I (n = 10) animals were infused (IU) with 10 ml garlic extract mixed with 90 ml normal saline, three times at 12 h interval starting from the day of estrum, whereas the animals of Group II (n = 10) were treated with a single injection of PGF 2 α (25 mg Lutalyse) on the 10 th to 12 th day after estrus, and group III (n = 6) remained as control. Cervico-vaginal mucus (CVM) was collected from each animal at pre- and post-treatment estrus and subjected to white side test, pH determination and total bacterial load. The clinical recovery of cows was assessed by negative white side test reaction, pH value and total bacterial count of CVM at subsequent estrus. The recovered animals were inseminated with frozen-thawed semen twice at 12 h intervals and pregnancy was confirmed at 45-60 days following insemination. A significant decline (p<0.05) in pH of CVM was observed in both the treatment groups at subsequent estrus. After treatment there was a significant (p<0.05) reduction in bacterial load, whereas, it was increased in control group. A total number of 65 isolates were identified in CVM samples comprising mostly of facultative anaerobic bacteria. Plasma T 4 and T 3 concentrations were increased in all the treated animals, whereas, a decline was observed in cortisol levels following treatment. The overall conception rate was 50% in treated groups as compared to nil pregnancy in the control.
Clinical Placement in Mental Health

Abstract The recruitment of students in health professions into the area of mental health has been shown to be influenced by their attitudes towards the area, with such attitudes possibly shaped in the same way as many of the attitudes towards mental illness are by the general community. The purpose of this study was to examine the attitudes of occupational therapy students and compare them with the attitudes of the general community, and further, to examine any changes in attitudes which occurred after completion of a fieldwork placement working with mentally ill people in community settings. Seventy-four third year occupational therapy students completed the Community Attitudes Towards the Mentally Ill (CAMI) instrument before, and at the completion of a 12 week fieldwork placement. Results showed that, before placement, students' attitudes towards the mentally ill were more positive than the attitudes of a community population, and after their community placement, the students' attitudes showed a significant and positive improvement. The implications of these findings are discussed and related to methods of teaching.
A Novel Electrochemical Sensor for Probing Doxepin Created on a Glassy Carbon Electrode Modified with Poly(4-Amino- benzoic Acid)/Multi-Walled Carbon Nanotubes Composite Film

A novel electrochemical sensor for sensitive detection of doxepin was prepared, which was based on a glassy carbon electrode modified with poly(4-aminobenzoic acid)/multi-walled carbon nanotubes composite film [poly(4-ABA)/MWNTs/GCE]. The sensor was characterized by scanning electron microscopy and electrochemical methods. It was observed that poly(4-ABA)/MWNTs/GCE showed excellent preconcentration function and electrocatalytic activities towards doxepin. Under the selected conditions, the anodic peak current was linear to the logarithm of doxepin concentration in the range from 1.0 × 10−9 to 1.0 × 10−6 M, and the detection limit obtained was 1.0 × 10−10 M. The poly(4-ABA)/MWNTs/GCE was successfully applied in the measurement of doxepin in commercial pharmaceutical formulations, and the analytical accuracy was confirmed by comparison with a conventional ultraviolet spectrophotometry assay.
Pragmatic randomized controlled trial of long‐term psychoanalytic psychotherapy for treatment‐resistant depression: the Tavistock Adult Depression Study (TADS)

This pragmatic randomized controlled trial tested the effectiveness of long‐term psychoanalytic psychotherapy (LTPP) as an adjunct to treatment‐as‐usual according to UK national guidelines (TAU), compared to TAU alone, in patients with long‐standing major depression who had failed at least two different treatments and were considered to have treatment‐resistant depression. Patients (N=129) were recruited from primary care and randomly allocated to the two treatment conditions. They were assessed at 6‐monthly intervals during the 18 months of treatment and at 24, 30 and 42 months during follow‐up. The primary outcome measure was the 17‐item version of the Hamilton Depression Rating Scale (HDRS‐17), with complete remission defined as a HDRS‐17 score ≤8, and partial remission defined as a HDRS‐17 score ≤12. Secondary outcome measures included self‐reported depression as assessed by the Beck Depression Inventory ‐ II, social functioning as evaluated by the Global Assessment of Functioning, subjective wellbeing as rated by the Clinical Outcomes in Routine Evaluation ‐ Outcome Measure, and satisfaction with general activities as assessed by the Quality of Life Enjoyment and Satisfaction Questionnaire. Complete remission was infrequent in both groups at the end of treatment (9.4% in the LTPP group vs. 6.5% in the control group) as well as at 42‐month follow‐up (14.9% vs. 4.4%). Partial remission was not significantly more likely in the LTPP than in the control group at the end of treatment (32.1% vs. 23.9%, p=0.37), but significant differences emerged during follow‐up (24 months: 38.8% vs. 19.2%, p=0.03; 30 months: 34.7% vs. 12.2%, p=0.008; 42 months: 30.0% vs. 4.4%, p=0.001). Both observer‐based and self‐reported depression scores showed steeper declines in the LTPP group, alongside greater improvements on measures of social adjustment. These data suggest that LTPP can be useful in improving the long‐term outcome of treatment‐resistant depression. End‐of‐treatment evaluations or short follow‐ups may miss the emergence of delayed therapeutic benefit.
Ischemic preconditioning does not alter muscle sympathetic responses to static handgrip and metaboreflex activation in young healthy men

Ischemic preconditioning (IPC) has been hypothesized to elicit ergogenic effects by reducing feedback from metabolically sensitive group III/IV muscle afferents during exercise. If so, reflex efferent neural outflow should be attenuated. We investigated the effects of IPC on muscle sympathetic nerve activity (MSNA) during static handgrip (SHG) and used post‐exercise circulatory occlusion (PECO) to isolate for the muscle metaboreflex. Thirty‐seven healthy men (age: 24 ± 5 years [mean ± SD]) were randomized to receive sham (n = 16) or IPC (n = 21) interventions. Blood pressure, heart rate, and MSNA (microneurography; sham n = 11 and IPC n = 18) were collected at rest and during 2 min of SHG (30% maximal voluntary contraction) and 3 min of PECO before (PRE) and after (POST) sham or IPC treatment (3 × 5 min 20 mmHg or 200 mmHg unilateral upper arm cuff inflation). Resting mean arterial pressure was higher following sham (79 ± 7 vs. 83 ± 6 mmHg, P < 0.01) but not IPC (81 ± 6 vs. 82 ± 6 mmHg, P > 0.05), while resting MSNA burst frequency was unchanged (P > 0.05) with sham (18 ± 7 vs. 19 ± 9 bursts/min) or IPC (17 ± 7 vs. 19 ± 7 bursts/min). Mean arterial pressure, heart rate, stroke volume, cardiac output, and total vascular conductance responses during SHG and PECO were comparable PRE and POST following sham and IPC (All P > 0.05). Similarly, MSNA burst frequency, burst incidence, and total MSNA responses during SHG and PECO were comparable PRE and POST with sham and IPC (All P > 0.05). These findings demonstrate that IPC does not reduce hemodynamic responses or central sympathetic outflow directed toward the skeletal muscle during activation of the muscle metaboreflex using static exercise or subsequent PECO.
Approximation Methods for Cylindrical Posts in Rectangular Waveguides with Mode Matching Technique

This paper analyzes the characteristics of two cylindrical posts placed in the cross section of a rectangular waveguide based on the mode matching technique. Three methods to approximate the posts are introduced: equal width method, arithmetic sequence thickness method and equal sector method. The scattering parameter convergence of these approximation methods is investigated. Meanwhile, through comparing the difference of the scattering parameters and the accurate values, the rate of convergence for each method is also explored, according to which, the most efficient approximation method is recommended. The calculated results of a symmetric two-post structure are compared with full-wave simulations using ANSYS HFSS.
The Development of Expertise: Animal Models?

There is a continuing debate in the psychological literature between researchers who lean more toward learning theories of expertise development and those who lean more toward talent theories. However, the development of human expertise has not been open to direct experimental methods and will probably continue to elude experimentalists in the future. A promising alternative to direct experimental methods is to use nonhuman animal models, a possibility that researchers in expertise seem to have overlooked. However, there are studies in the animal behavior literature that address the development of nonhuman animal expertise without specifically referring to the topic as expertise. In the present study, the author discusses two nonhuman animal examples of expertise development that have been researched by ethologists. Nonhuman animal expertise development, unlike human expertise development, is subject to direct experimentation. The author thus recommends that researchers use nonhuman animals in their studies of expertise.
A new approach to short-time harmonic analysis of tonal audio signals using harmonic sinusoidals

This paper presents a novel short-time frequency analysis algorithm, namely Instantaneous Harmonic Analysis (IHA), which can be used in Multiple Fundamental Frequency Estimation. Given a set of reference pitches, the objective of the algorithm is to transform the real-valued time-domain audio signal into a set of complex time-domain signals in such a way that the amplitude and phase of the resulting signals represent the amplitude and phase of the signal components with respect to the reference pitches. In the proposed algorithm, the instantaneous amplitude is identified as the presence of the pitch in time. The algorithm has been applied to three synthetic data sets for pureharmonic, one-overtone, and two-overtone data in a MIDI format and the results are reported here. To overcome the harmonic collision, a bottom of approach has been used for overtones elimination. A note event post-processing algorithm has also been developed for further analysis by representing the IHA output in the beat resolution.
Multi-label active learning for image classification with asymmetrical conditional dependence

Image classification is a hot topic of pattern recognition in computer vision. In order to achieve high accuracy of classification, a certain amount of high quality pictures are needed. As a matter of fact, high quality pictures are scarce. Active learning can solve such a problem. Label dependences play an important role in multi-label active learning for image classification. The interdependences between different labels are usually different and asymmetrical. This paper first brings the asymmetrical conditional label dependences into a novel active learning method for multi-label image classification based on the asymmetrical conditional label dependence, called ACDAL. Our extensive experimental results on three image and two non-image datasets show that our new approach ACDAL significantly outperforms existing approaches.
Application of information technology may increase the efficacy of Confidential Unit Exclusion (CUE) in blood donors

Confidential Unit Exclusion (CUE) refers to a procedure by which a blood donor designates confidentially whether his or her blood might not be safe for transfusion. It applies to situations in which an individual who is not eligible for blood donation in terms of blood safety feel pressured by others to donate his or her blood. A potential problem in the CUE system is misunderstanding of the procedure and its significance by blood donors as well as the lack of their confidence regarding the confidentiality of their private information. Since the Information and Communication Technology (ICT) provides a secure and confidential atmosphere, it is expected the application of ICT have a positive impact on the efficacy of CUE system.
RF-Based Location System in Harsh Environment

RF-based location tracking in industrial environment possesses many challenges due to the complex propagation condition. This paper will address some of the problems in this environment. Firstly, we evaluate the performance of RF-based tracking in a harsh environment, i.e. in a car manufacturing plant. Secondly, the research presents a comprehensive study of an algorithm that utilises Bayesian filters, leading to robust location and tracking estimation. The evaluation of the location system was conducted in three test-beds. One test-bed mimics an office environment and the second and the third an assembly hall in car manufacturing plant.
Globalisation of Stone Tools and Beginnings of Mechanical Processing of Polymers

Based on research on influence of rubber and plastics on globalization, an interesting question arose: can we define the first globalization way of material culture? Manufacturing of first stone tools can be seen at the site of Gona, Ethiopia (dated to 2,6 million years ago), followed by several sites including the evidence from West Turkana in Kenya (2,74 - 1.94 million years ago), Olduvai in Tanzania and Sterkfontain in South Africa (2 - 1,6 million years ago). The products found at the sites were simple stone choppers, chopping tools and flakes. We used synthesiological approach and combined the knowledge from archaeology, production technology and the field of polymers in order to approach the interesting question relating to the aforementioned finds: for which purpose these tools were used? Firstly, the manufactured stone tools were used for procedures such as breaking of the natural polymers: e.g. crushing of the larger bones in order to obtain the marrow, and for butchering of animals.
Development of a β-Lactamase Reporter Gene Assay for Metabotropic Glutamate Receptor 1 by Using Coexpression of Glutamate Transporter

mGluR1 antagonists have been postulated to be novel CNS drugs, including antipsychotics. Toward this end, the authors developed a β-lactamase reporter assay to identify mGluR1 antagonists. β-Lactamase has several interesting features for high-throughput screening, including very high sensitivity and less well-to-well variation than other reporter enzymes. mGluR1-expressing Chinese hamster ovary (CHO) cells with the β-lactamase gene under control of the nuclear factor of activated T cells (NFAT) promoter (CHO-NFAT-bla-hmGluR1b) exhibited very high basal activity, resulting in an inadequate signal-to-basal (S/B) ratio. Coexpression of glutamate/aspartate transporter (GLAST) with mGluR1 in the cell line (CHO-NFAT-bla-hmGluR1b-GLAST) dramatically decreased basal activity and improved the S/B ratio (from 2- to 20-fold). The contribution of GLAST to lowering basal activity and increasing the S/B ratio was validated by the expression level of GLAST mRNA and by a GLAST inhibitor. Antagonistic activities of known mGluR1 antagonists in the β-lactamase reporter assay were comparable with those in the conventional Ca2+ mobilization assay. The Z′ factor of the β-lactamase reporter assay was 0.89 under optimized conditions. Taken together, the β-lactamase reporter assay with CHO-NFAT-bla-hmGluR1b-GLAST could be a novel high-throughput assay for mGluR1 antagonist screening. This is the first description of a successful β-lactamase reporter assay among all mGluR subtypes.
Dynamics of distributed shortest-path routing algorithms

The dynamics of shortest-path routing algorithms bss.ed on distance vectors and link states are investigated. Detailed quantitative comparisons of the distributed Belhnen-Ford algorithm used in several routing protocols in the paa~ an ideal link-state ttlgonthm similar to the one used in OSPF and in the 0S1 intradomain routing protocol, and a loop-free distance-vector algorithm, are made for the network topologies of the 1988 ARPANET, LOSNE’ITOS, DOE-ESNET, and the NSFNET T1 Backbone. Comparisons include the response of the algorithms to link-cost changes and to link end node failures and recoveries. A variety of quantities, including the length of messages and the average nutnber of paths affected by routing lceps, are computed as a function of time after a link or node change. Probabilities of various conditions are also obtained as a function of time, including the existence of loops. As expected, the dwtributed Belhnen-Ford algorithm behaves poorly compared with the other two. However, deciding between a routing protocol based on a link-state algorithm and one based on a loop-free d~tance-vector algorithm depends on the particular network in which it will perform.