Miracle-dz/UniFAR-FTUs huggingface dataset:
Noncommutative line bundles associated to twisted multipullback quantum odd spheres

We construct a noncommutative deformation of odd-dimensional spheres that preserves the natural partition of the $(2N+1)$-dimensional sphere into $(N+1)$-many solid tori. This generalizes the case $N=1$ referred to as the Heegaard quantum sphere. Our twisted odd-dimensional quantum sphere $C^*$-algebras are given as multi-pullback $C^*$-algebras. We prove that they are isomorphic to the universal $C^*$-algebras generated by certain isometries, and use this result to compute the $K$-groups of our odd-dimensional quantum spheres. Furthermore, we show that the natural (diagonal) $U(1)$-actions on our twisted-quantum-sphere $C^*$-algebras are $C^*$-free, and define twisted multipullback quantum complex projective spaces through fixed-point subalgebras for these actions. In the untwisted case, we prove that the fixed-point subalgebras yield the independently defined $C^*$-algebras of the quantum complex projective spaces constructed from Toeplitz cubes. This leads to the main result stating that the noncommutative line bundles associated to multipullback quantum odd spheres, which are noncommutative line bundles over these quantum complex projective spaces, are pairwise stably non-isomorphic.
Virtual Screening of Potential Drug-like Inhibitors against MexB Efflux Protein from Pseudomonas Aeruginosa

Prevalence of multidrug resistant Pseudomonas aeruginosa strains in clinical setup demands the need for developing potent drugs against efflux mechanisms. In this study, drug-like molecules with structural similarity to the known efflux inhibitor were used in order to screen for potential inhibitors. A total of 167 compounds were screened and the Glide XP shortlisted compounds were selected based on Glide score and interaction with active site residues. The virtual screening method was also applied to study the binding modes of substrates. The shortlisted compound could have a better ability to inhibit the MexB protein, hence will provide adjunctive therapy t o the antibiotics. Keywords-Pseudomonas aeruginosa; virtual screening; efflux pump; MC-207, 110; Glide
Self Heating in InP DHBT Technology for 40 Gb/s ICs

Abstract Self heating is investigated in InP/InGaAs DHBT’s, a transistor technology well suited for 40 Gb/s IC’s. An original approach associates experiments andsimulations. InP DHBT’s are shown to heat up even if their I-V characteristics do not present a negativedifferential output conductance as GaAs HBT’s do.Their thermal resistance was found in the same range of values both using physical modeling and pulsedmeasurements coupled with electrical modeling. 1. Introduction High performance InP/InGaAs DHBT’s grown bychemical beam epitaxy (CBE) have been reported with 180 GHz f T , 185 GHz f MAX , a gain of 50 at a current density of 1x105 A.cm -2 , a breakdown voltage>5 V [1]. Thesefeatures are required for circuits found in 40 Gb/s IC’s. On the other side, the more established GaAs HBT’s are known to be subjected to self-heating. It is attributed to the GaAs poor thermal conductivity(K GaAs =0.455W.(cm.K) -1 ) and to the large thresholdvoltage of these heterostructures. In comparison, there is few information available on self heating in InP HBT’s [2-3]. Although K
Dense Semantic 3 D Reconstruction

Both image segmentation and dense 3D modeling from images represent an intrinsically ill-posed problem. Strong regularizers are therefore required to constrain the solutions from being ’too noisy’. These priors generally yield overly smooth reconstructions and/or segmentations in certain regions while they fail to constrain the solution sufficiently in other areas. In this paper, we argue that image segmentation and dense 3D reconstruction contribute valuable information to each other’s task. As a consequence, we propose a mathematical framework to formulate and solve a joint segmentation and dense reconstruction problem. On the one hand knowing about the semantic class of the geometry provides information about the likelihood of the surface direction. On the other hand the surface direction provides information about the likelihood of the semantic class. Experimental results on several data sets highlight the advantages of our joint formulation. We show how weakly observed surfaces are reconstructed more faithfully compared to a geometry only reconstruction. Thanks to the volumetric nature of our formulation we also infer surfaces which cannot be directly observed for example the surface between the ground and a building. Finally, our method returns a semantic segmentation which is consistent across the whole dataset.
Towards Automatic Reversible Jump Markov Chain Monte Carlo

Since its introduction by Green (1995), reversible jump MCMC has been recognised as a powerful tool for making posterior inference about a wide range of statistical problems. Despite enjoying considerable application across a variety of disciplines, the method’s popularity has been tempered by the common perception that reversible jump samplers can be difficult to implement. Beginning with a review of reversible jump methods and recent research in the area, this thesis introduces steps towards the design of an automatic reversible jump sampler with the aim of taking the method outside of the domain of the MCMC expert. The need for a sampler is discussed and motivated by an application of reversible jump to a recent problem in biology. We build upon recent developments in the area of adaptive sampling, analysing and extending existing methods for their inclusion in an automatic reversible jump sampler. The automatic sampler that we introduce in the penultimate chapter of the thesis builds upon the first steps taken by Green (2003). Requiring minimal user input, it uses adaptive techniques to perform self-tuning and calibration for many trans-dimensional statistical problems. The broad applicability of the sampler is detailed, as are typical results, indicating performance comparable to problemspecific samplers, designed and tuned by hand. The thesis ends with some suggestions for further work. 3
Precise distance measurement with cooperative FMCW radar units

In many applications the precise distance between different units has to be measured. The proposed measurement system operates with frequency modulated continuous wave (FMCW) radar sensors for distance measurement in a cooperative but unsynchronized way. Due to the missing synchronization a data transfer between the units is performed by means of the radar hardware. On the other hand, this principle could be easily implemented in communication systems. A prototype system in the 5.8-GHz ISM band has been built, and measurement results up to about 780 meters distance with accuracies of few centimeters are shown. Furthermore, the distance can be calculated at both transponder units.
An investigation of preferential fibroblast wound repopulation using a novel in vitro wound model.

To overcome the difficulties of studying wounding and wound repopulation in monolayer systems, a 3-dimensional model of wound repopulation has been developed which allows the in vitro investigation of fibroblast migration in response to experimental wounding. This model was utilized to determine whether fibroblasts derived from sites which demonstrate preferential healing (child and oral mucosal fibroblasts) possessed an increased ability to repopulate experimental wounds when compared to adult dermal fibroblasts. Fibroblasts were established from specimens derived from healthy donors undergoing minor elective surgery. Standard wounds were created in fibroblast populated collagen lattices (FPCLs) which were then overlaid upon an extracellular wound matrix. Fibroblast repopulation of the wounds was studied over 12 days using light- and scanning electron microscopy and quantified using computerized image analysis. Wound repopulation by fibroblasts derived from child donors (n = 3) was significantly (P < 0.001) more rapid than their adult tissue-matched counterparts (n = 3). Wound repopulation by oral mucosal fibroblasts (n = 3) was significantly greater than that exhibited by age-matched dermal fibroblasts (n = 3; P < 0.05). These differences were not reflected in differences in DNA synthesis (P > 0.5) or cell number (P > 0.5) within similar attached FPCL systems. These findings further support the concept of a gradual transition from the fetal to adult phenotype in wound healing. The potential applications of the model are discussed.
Millimeterwave radar for SAR on UAVs with real-time image display

Modern synthetic aperture radar (SAR) systems giving very high resolution have to be light and small in size to fit in small aircrafts. In this paper we show a newly designed SAR system operating at 94 GHz using a high flexible frequency generation module. This very new concept ensures a very linear signal generation which was formerly known from arbitrary waveform generators. The bandwidth of the system allows measurements up to 3.8 GHz bandwidth. We have flown this SAR-system using a model aircraft as well as a microlight and show real-time processed SAR-images. In addition we tested different kinds of inertial measurement units (IMU) to determine the minimum requirements for optimal SAR measurements.
The efficacy of three class I topical synthetic corticosteroids, fluocinonide 0.1% cream, clobetasol 0.05% cream and halobetasol 0.05% cream: a Scholtz-Dumas bioassay comparison.

BACKGROUND This study compared the efficacy of a novel, topical class I synthetic, 0.10% fluocinonide corticosteroid with two other class I corticosteroids and placebo for the treatment of plaque psoriasis. METHODS A 0.5 gram dose of fluocinonide 0.1% cream, clobetasol propionate 0.05% cream, halobetasol propionate 0.05% cream, and placebo ointment were applied to test sites on one psoriatic plaque per patient (n=5). Test sites were outlined according to the Scholtz-Dumas bioassay. Test sites were assessed by a blinded evaluator (1 = psoriasis worsened to 5 = psoriasis clear or almost clear), cleaned and medications were reapplied on days 3, 5, 7, 10 and 12. RESULTS & CONCLUSION The three class I corticosteroid products were comparably effective, numerically and statistically, in clearing the psoriatic plaques. Upon completion of treatment, 60-80% of active-treated sites were clear or almost clear of psoriasis compared to zero with the placebo.
Competing in Information-Intensive Services: Analyzing the Impact of Task Consolidation and Employee Empowerment

We analyze the competitive and economic implications of information technology, the allocation of decision rights, and task bundling during business process reengineering. The popular reengineering literature advocates employee empowerment--decentralizing decision authority and consolidating tasks--as complementary strategies. Our analysis reveals, however, that implementing these two changes simultaneously is suboptimal in many cases. Decentralization and consolidation decisions can occur separately or together; the optimal combination depends on the effectiveness of technology aimed at skill enhancement and the customers' sensitivity to time and quality. We identify those process parameters that can cause decentralization and consolidation to have opposite effects on process performance; we also point to other parameters, such as customer-to-customer variability, which can cause them to complement one another. Finally, we explain why, in a time-based competitive marketplace, firms are more likely to centralize their decision-making process while concentrating their information technology investments on enhancing productivity and intraorganizational communications.
A 0.89-mW 1-MHz 62-dB SNDR Continuous-Time Delta–Sigma Modulator With an Asynchronous Sequential Quantizer and Digital Excess-Loop-Delay Compensation

A second-order continuous-time delta-sigma modulator incorporating a proposed 4-bit asynchronous sequential quantizer and a digital excess-loop-delay (ELD) compensation technique is presented. The sequential operation of the proposed quantizer facilitates low power consumption while the hardware-efficient digital compensation technique allows the modulator to accommodate ELD. With a 1-MHz bandwidth and a 60-MHz sampling rate, the measured peak signal-to-noise-and-distortion ratio and dynamic range are 62 and 67 dB, respectively. Fabricated in a 90-nm CMOS, this chip consumes only 0.89 mW from a 1.2-V supply.
Intramyocellular lipid quantification: repeatability with 1H MR spectroscopy.

PURPOSE To prospectively determine the repeatability and variability of tibialis anterior intramyocellular lipid (IMCL) quantifications performed by using 1.5-T hydrogen 1 (1H) magnetic resonance (MR) spectroscopy in healthy subjects. MATERIALS AND METHODS Institutional review board approval and written informed consent were obtained for this Health Insurance Portability and Accountability Act-compliant study. The authors examined the anterior tibial muscles of 27 healthy subjects aged 19-48 years (12 men, 15 women; mean age, 25 years) by using single-voxel short-echo-time point-resolved 1H MR spectroscopy. During a first visit, the subjects underwent 1H MR spectroscopy before and after being repositioned in the magnet bore, with voxels carefully placed on the basis of osseous landmarks. Measurements were repeated after a mean interval of 12 days. All spectra were fitted by using Java-based MR user interface (jMRUI) and LCModel software, and lipid peaks were scaled to the unsuppressed water peak (at 4.7 ppm) and the total creatine peak (at approximately 3.0 ppm). A one-way random-effects variance components model was used to determine intraday and intervisit coefficients of variation (CVs). A power analysis was performed to determine the detectable percentage change in lipid measurements for two subject sample sizes. RESULTS Measurements of the IMCL methylene protons peak at a resonance of 1.3 ppm scaled to the unsuppressed water peak (IMCL(W)) that were obtained by using jMRUI software yielded the lowest CVs overall (intraday and intervisit CVs, 13.4% and 14.4%, respectively). The random-effects variance components model revealed that nonbiologic factors (equipment and repositioning) accounted for 50% of the total variability in IMCL quantifications. Power analysis for a sample size of 20 subjects revealed that changes in IMCL(W) of greater than 15% could be confidently detected between 1H MR spectroscopic measurements obtained on different days. CONCLUSION 1H MR spectroscopy is feasible for repeatable quantification of IMCL concentrations in longitudinal studies of muscle metabolism.
Analytical considerations for quantitative determination of serotonin and its metabolically related products in biological matrices.

We discuss the use of "high-performance" liquid chromatography with electrochemical detection for the quantification fo serotonin (5-hydroxytryptamine) and metabolically related products (i. e., 5-hydroxyindoleacetic acid and 5-hydroxytryptophan) in biological matrices. Two methods are described: one for routine quantification of nanogram amounts or more; the other a two-column purification-separation ("trace enrichment") technique for determining subnanogram amounts of these compounds. Various factors affecting the liquid-chromatographic separation and quantification of 5-hydroxy-indoles are detailed, including selection of appropriate internal standard, sample purification, and effects of changes in mobile phase composition, e.g., ion-pair reagent, organic modifier content, and pH. We describe in detail the trace-enrichment method for determinations in the range of 25 pg to 25 ng, and discuss the general factors to consider when developing or modifying an assay for specific applications.
Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions

Mitochondrial dysfunction in white adipose tissue plays a key role in the pathogenesis of type 2 diabetes. Emerging evidence specifically suggests that altered oxidative phosphorylation in adipocytes may have a relevant effect on systemic glucose homeostasis, requiring understanding of adipocyte bioenergetics. We analyzed energetic flux of an intact human adipocyte cell model by plate‐based respirometry and extracellular acidification. During differentiation, we discovered that glycolytic ATP production was increasingly replaced by mitochondrial oxidative metabolism (from 20 to 60%). This observation was corroborated by simultaneous up‐regulation of canonical mitochondrial gene programs, such as peroxisome proliferator‐activated receptor γ coactivator α (PGC1α; 150‐fold) and cytochrome c‐1 (CytC; 3‐fold). Mimicking diabetic phenotypes by exposure to various glucose levels (0, 5, and 25 mM) resulted in immediate adjustments of glycolytic and mitochondrial activity that aimed to maintain intracellular ATP. We conclude that ATP deficits by mitochondrial failure are compensated by glycolytic ATP production, resulting in inefficient conversion of glucose to cellular ATP. Metabolic inefficiency may enhance glucose uptake, therefore improving systemic glucose homeostasis. Notably, mature adipocytes developed a high spare respiratory capacity (increased by 6‐fold) permitting rapid adaptation to metabolic changes. Spare respiratory capacity may also allow additional metabolic scope for energy dissipation, potentially offering new therapeutic targets for the treatment of metabolic disease. —Keuper, M. , Jastroch, M. , Yi, C. ‐X. , Fischer‐Posovszky, P., Wabitsch, M. , Tschöp, M. H. , Hofmann, S. M. Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions. FASEB J. 28, 761–770 (2014). www.fasebj. org
Author ' s personal copy A faster aggregation for 3 D fast evanescent wave solvers using rotations

A novel technique to accelerate the aggregation and disaggregation stages in evanescent plane wave methods is presented. The new method calculates the six plane wave radiation patterns from a multipole expansion (aggregation) and calculates the multipole expansion of an incoming field from the six plane wave incoming field patterns. It is faster than the direct approach for multipole orders larger than one, and becomes six times faster for large multipole orders. The method relies on a connection between the discretizations of the six integral representations, and on the fact that the Wigner D-matrices become diagonal for rotations around the z-axis. The proposed technique can also be extended to the vectorial case in two different ways, one of which is very similar to the scalar case. The other method relies on a Beltrami decomposition of the fields and is faster than the direct approach for any multipole order. This decomposition is also not limited to evanescent wave solvers, but can be used in any vectorial multilevel fast multipole algorithm. 2007 Elsevier Inc. All rights reserved.
Investigating the Incidence of Prostate Cancer in Iran 2005 -2008 using Bayesian Spatial Ecological Regression Models.

BACKGROUND Prostate cancer is the most commonly diagnosed form of cancer and the sixth leading cause of cancer-related deaths among men in the entire world. Reported standardized incidence rates are 12.6, 61.7, 11.9 and 27.9 in Iran, developed countries, developing countries and the entire world, respectively. The present study investigated the relative risk of PC in Iran at the province level and also explored the impact of some factors by the use of Bayesian models. MATERIALS AND METHODS Our study population was all men with PC in Iran from 2005 to 2008. Considered risk factors were smoking, fruit and vegetable intake, physical activity, obesity and human development index. We used empirical and full Bayesian models to study the relative risk in Iran at province level to estimate the risk of PC more accurately. RESULTS In Iran from 2005 to 2008 the total number of known PC cases was 10,361 with most cases found in Fars and Tehran and the least in Ilam. In all models just human development index was found to be significantly related to PC risk Conclusions: In the unadjusted model, Fars, Semnam, Isfahan and Tehran provinces have the highest and Sistan-and-Baluchestan has the least risk of PC. In general, central provinces have high risk. After adjusting for covariates, Fars and Zanjan provinces have the highest relative risk and Kerman, Northern Khorasan, Kohgiluyeh Boyer Ahmad, Ghazvin and Kermanshah have the lowest relative risk. According to the results, the incidence of PC in provinces with higher human development index is higher.
A Comparison of the Responsiveness of 4 Commonly Used Patient-Reported Outcome Instruments at 5 Years After Matrix-Induced Autologous Chondrocyte Implantation

Background: Patient-reported outcome (PRO) instruments are employed to assess outcomes after matrix-induced autologous chondrocyte implantation (MACI), although the PRO most responsive to change after surgery remains unknown. Purpose: To compare the responsiveness of 4 commonly used PRO instruments at 5 years after MACI. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: The Knee Injury and Osteoarthritis Outcome Score (KOOS), the Lysholm score, the Tegner activity scale, and the 36-item Short Form Health Survey (SF-36) were administered to 104 patients before and at 5 years after MACI knee surgery. The Self-administered Patient Satisfaction Scale was employed at 5 years to investigate each patient’s overall level of satisfaction as well as satisfaction with relieving pain and improving the ability to perform daily activities, partake in recreational activities, and participate in sport. The effect size (ES) and standardized response mean (SRM) were used to compare PRO responsiveness. A receiver operating characteristic (ROC) curve analysis was performed to evaluate the extent to which PRO changes were associated with satisfaction. The minimal clinically important difference (MCID) according to the criterion of patient satisfaction was identified as the PRO instrument change score maximizing classification accuracy. Results: The most responsive PRO measures were the KOOS sport/recreation (ES, 1.63; SRM, 1.43) and quality of life (QOL) (ES, 1.37; SRM, 1.18) subscales. The least responsive were the SF-36 mental component summary (MCS) (ES, 0.38; SRM, 0.40) and the Tegner activity scale (ES, 0.91; SRM, 0.59). Of the 104 patients, 54 (51.9%) reported being “very satisfied,” 38 (36.5%) “somewhat satisfied,” 8 (7.7%) “somewhat dissatisfied,” and 4 (3.9%) “very dissatisfied. ” A ROC curve analysis was performed using “very satisfied” as the responder criterion. The strongest association was between the change in KOOS sport/recreation with satisfaction in improving the ability to perform recreational activities (area under the curve, 0.756; 95% confidence interval, 0.663-0.849), and the change score maximizing prediction accuracy (MCID) was 40 (sensitivity, 69%; specificity, 76%). Conclusion: The KOOS sport/recreation and QOL subscales were the most responsive PRO measures and were most predictive of satisfaction. This information will provide a guide as to the improvements required in pertinent PRO measures to produce a satisfied patient, while allowing researchers to better structure trials in these patients using the most relevant PRO instruments.