Miracle-dz/UniFAR-FTUs huggingface dataset:
Perceiving Relationship Success Through a Motivational Lens: A Regulatory Focus Perspective

The current research examined the hypothesis that the relative importance of growth- and security-related relationship qualities in establishing successful relationships depends on the motivational orientation—regulatory focus (Higgins, 1997)—of the individual. Across four studies, we found that individuals in a promotion focus, whether chronic (Studies 1-2, 4) or temporarily induced (Study 2), prioritized the presence of relationship growth versus security in perceiving relationship success (Studies 1-2), rated their own relationship well-being higher when growth (but not security) qualities were present (Study 3), and experienced heightened relationship well-being when room for growth was manipulated to appear abundant versus limited (Study 4). In contrast, prevention-focused individuals did not place as much emphasis on growth relative to security (Studies 1 and 3) and, when forced to choose, preferred a relationship characterized by security versus growth (Study 2). These findings suggest the value of considering motivational orientations in understanding how relationship success is experienced.
Foxl2 and Its Relatives Are Evolutionary Conserved Players in Gonadal Sex Differentiation

Foxl2 is a member of the large family of Forkhead Box (Fox) domain transcription factors. It emerged during the last 15 years as a key player in ovarian differentiation and oogenesis in vertebrates and especially mammals. This review focuses on Foxl2 genes in light of recent findings on their evolution, expression, and implication in sex differentiation in animals in general. Homologs of Foxl2 and its paralog Foxl3 are found in all metazoans, but their gene evolution is complex, with multiple gains and losses following successive whole genome duplication events in vertebrates. This review aims to decipher the evolutionary forces that drove Foxl2/3 gene specialization through sub- and neo-functionalization during evolution. Expression data in metazoans suggests that Foxl2/3 progressively acquired a role in both somatic and germ cell gonad differentiation and that a certain degree of sub-functionalization occurred after its duplication in vertebrates. This generated a scenario where Foxl2 is predominantly expressed in ovarian somatic cells and Foxl3 in male germ cells. To support this hypothesis, we provide original results showing that in the pea aphid (insects) foxl2/3 is predominantly expressed in sexual females and showing that in bovine ovaries FOXL2 is specifically expressed in granulosa cells. Overall, current results suggest that Foxl2 and Foxl3 are evolutionarily conserved players involved in somatic and germinal differentiation of gonadal sex.
Clinical Epidemiology, Evaluation, and Management of Dementia in Parkinson Disease

The prevalence of neurodegenerative diseases such as Parkinson disease (PD) will increase substantially, due to the aging of the population and improved treatments leading to better disease-related outcomes. Dementia is the most common nonmotor symptom in PD, and most patients with PD will have cognitive dysfunction and cognitive decline in the course of their disease. The development of cognitive dysfunction in PD greatly limits the ability to participate in activities of daily living and can be a tipping point for nursing home placement or major caregiver stress. Understanding the different causes of dementia and how to reduce the incidence and impact of secondary cognitive dysfunction in PD are necessary skills for primary care physicians and neurologists. In this review, we discuss the clinical epidemiology of dementia in PD with an emphasis on preventable cognitive dysfunction, present tools for outpatient evaluation of cognitive dysfunction, and describe current pharmacological treatments for dementia in PD.
Recipient Adipose-Derived Stem Cells Enhance Recipient Cell Engraftment and Prolong Allotransplant Survival in a Miniature Swine Hind-Limb Model

Donor mesenchymal stem cells (MSCs) could prolong vascularized composite allotransplantation (VCA) survival in our previous studies. However, recipient adipose tissue is easier to harvest than donor tissue for preconditioning modulation. Hence, this study investigated the efficacy of recipient autologous adipose-derived stem cells (rADSCs) for VCA survival. The heterotopic hind-limb transplantation from female donor to male recipient was performed in outbred miniature swine. Group I (n = 6) was untreated controls. Group II (n = 4) obtained rADSCs infusions (given on weeks 0, +1, +2, and +3). Group III (n = 4) obtained tacrolimus (FK506, weeks 0 to +4). Group IV (n = 8) received irradiation (IR; day −1), FK506 (weeks 0 to +4), and rADSC infusions (weeks 0, +1, +2, and +3). The results revealed treatment with multiple injections of rADSCs along with IR and FK506 resulted in a statistically significant increase in allograft survival. The percentage of CD4+/CD25+/Foxp3+ regulatory T cells were significantly increased in the rADSC-IR-FK506 group as compared to controls. Analysis of recipient peripheral blood revealed that transforming growth factor β1 (TGFβ1) was significantly increased in the rADSC-IR-FK506 group. The polymerase chain reaction (PCR) analysis and immunohistochemical staining showed recipient sex-determining region of Y (SRY) chromosome gene expression existed in donor allotissues in the rADSC-IR-FK506 group. These results indicate that rADSCs in addition to IR and transient immunosuppressant could prolong allotransplant survival, modulate T-cell regulation, and enhance recipient cell engraftment into the allotransplant tissues.
Partial and Total Annoyance Due to Road Traffic Noise Combined with Aircraft or Railway Noise: Structural Equation Analysis

Structural equation modeling was used to analyze partial and total in situ annoyance in combined transportation noise situations. A psychophysical total annoyance model and a perceptual total annoyance model were proposed. Results show a high contribution of Noise exposure and Noise sensitivity to Noise annoyance, as well as a causal relationship between noise annoyance and lower Dwelling satisfaction. Moreover, the Visibility of noise source may increase noise annoyance, even when the visible noise source is different from the annoying source under study. With regards to total annoyance due to road traffic noise combined with railway or aircraft noise, even though in both situations road traffic noise may be considered background noise and the other noise source event noise, the contribution of road traffic noise to the models is greater than railway noise and smaller than aircraft noise. This finding may be explained by the difference in sound pressure levels between these two types of combined exposures or by the aircraft noise level, which may also indicate the city in which the respondents live. Finally, the results highlight the importance of sample size and variable distribution in the database, as different results can be observed depending on the sample or variables considered.
ARMing the Trusted Platform Module pro-active system integrity monitoring focussing on peer system notification

The concept of Trusted Computing offers a hardware platform based on which the integrity of IT systems is verified using a structured file-based signature hierarchy of all executable system components - from BIOS boot up to the execution of any user application. Current implementations detect integrity breaches at firmware and at file level so that suitable counter measures on a Trusted Computing system may be taken in almost real-time. This information - so far - either remains stored locally or in best case is forwarded at application layer leaving enough time for a smart malware to infect a peering system or to compromise application level communication. This paper introduces a new pro-active concept of integrity monitoring and reporting using the Trusted Platform Module to supervise the integrity of a system focusing on incident reporting to peering systems at link layer. For this concept we suggest the enhancement of the Trusted Platform Module by a new Attack Recognition Module to monitor a system in real time and to reliably notify peering systems about any integrity breach detected.
Targeted siRNA delivery to diseased microvascular endothelial cells—Cellular and molecular concepts

Increased insight in the role of endothelial cells in the pathophysiology of cancer, inflammatory and cardiovascular diseases, has drawn great interest in pharmacological interventions aiming at the endothelium in diseased sites. Their location in the body makes them suitable targets for therapeutic approaches based on targeted drug delivery. Functional heterogeneity of the microvascular bed in normal organ homeostasis has been appreciated for a long time, and more recent studies have revealed heterogeneity in endothelial reactivity to inflammatory stimuli as well. Upon stimulation, each organ displays a vascular bed specific pattern of cell adhesion molecules providing challenging opportunities to deliver drugs or small RNAs to organ specific (micro)vascular endothelial subsets. In this review we introduce general concepts of endothelial heterogeneity in relation to disease state and its consequences for targeted therapeutic interventions. Furthermore, we will describe novel approaches to interfere with endothelial cell engagement in disease with a main focus on siRNA therapeutics and currently used nonviral lipid and polymer‐based siRNA delivery systems. The last part of this review addresses some technical issues that are essential in proving the concept of target mRNA knock down in a vascular bed specific manner, and the further development of effective endothelial cell specific drug delivery devices. © 2011 IUBMB IUBMB Life, 2011
PERIOD1-Associated Proteins Modulate the Negative Limb of the Mammalian Circadian Oscillator

The clock proteins PERIOD1 (PER1) and PERIOD2 (PER2) play essential roles in a negative transcriptional feedback loop that generates circadian rhythms in mammalian cells. We identified two PER1-associated factors, NONO and WDR5, that modulate PER activity. The reduction of NONO expression by RNA interference (RNAi) attenuated circadian rhythms in mammalian cells, and fruit flies carrying a hypomorphic allele were nearly arrhythmic. WDR5, a subunit of histone methyltransferase complexes, augmented PER-mediated transcriptional repression, and its reduction by RNAi diminished circadian histone methylations at the promoter of a clock gene.
When a Celebrity Is Tied to Immoral Behavior: Consumer Reactions to Michael Jackson and Kobe Bryant

EXTENDED ABSTRACT When a celebrity's identity is linked to implications of immoral behavior, the reactions of consumers to the celebrity will determine whether their careers can continue to generate profits in the entertainment industry or as endorsers. However, the reactions of consumers tend to vary, from absolute belief in the celebrity's innocence to absolute belief in his guilt. For example, reactions to the recent charges against Michael Jackson and Kobe Bryant illustrate the widely varied reactions of consumers. In the case of Michael Jackson, the media coverage emphasizes the reactions of his ardent fans who believe he is absolutely innocent, in implicit contrast with others who believe that he is probably guilty of the charges against him. Similarly, the media coverage suggests that many people believe Kobe Bryant is innocent of the charges that were made against him. However, many of the companies who had used him as an endorser are not taking the risk that their products will become associated with a man perceived as a rapist in the minds of some of their consumers.
Civic Implications of Secondary School Journalism

This study examines the association between high school journalism and civic engagement in early adulthood, independent of other civic activities. Nationally representative data show that taking high school journalism classes is related positively to voting in the years following high school, to a similar degree that taking debate classes or participating in student government is related to voting. High school journalism also moderates the association between family socioeconomics and civic engagement. Underprivileged student journalists tend to vote and volunteer more than their non-journalism peers. The study theorizes journalism education’s unique contributions to civic development and civic communication competence.
Terrestrial Free Space Optical Links for High Bandwidth Connectivity

Free space optics (FSO) is rapidly gaining popularity as an effective means of transferring data at high rates over short distances. Light beams propagating through the atmosphere carry the information from the optical transmitter to the receiver. FSO facilitates rapidly deployable, lightweight, high-bandwidth communication without licensing fee and tariffs. We present FSO system and network concepts, modeling of the terrestrial (near ground) channel, modulation and channel coding aspects and investigations in estimating the probability density function
Control of nuclear reactor power with thermal-hydraulic effects via fuzzy PIγDμ controllers

A nonlinear nuclear reactor model is linearized at different initial powers for the purpose of controlling the reactor in load following mode. A new fractional order (FO) fuzzy proportional integral derivative (PID) controller is tuned next using Genetic Algorithm (GA) to control the reactor at different operating conditions. The effectiveness of using the fuzzy FOPID controller over conventional fuzzy PID controllers is shown with credible numerical simulations. The controllers tuned with the highest and lowest power models are shown to work well at other operating conditions also and hence are robust with respect to the changes in nuclear reactor power level.
A SiGe-based E-band power amplifier with 17.7 dBm output power and 325-GHz GBW

A high-gain, wideband power amplifier (PA) in 0.18-μm SiGe HBT technology covering the three high-speed E-band communication channels (71-76 GHz, 81-86GHz and 92-95 GHz) is presented. The architecture is based on a class-A three stage cascode amplifier. Bandwidth enhancement is achieved using inter-stage lossy-matching and gain-staggering techniques. The PA demonstrates a peak small-signal gain of 23dB and a saturated output power (Psat) of 17.7 dBm with a 14.8% power-added efficiency (PAE). With a 3-dB gain and Psat bandwidth of about 23GHz, it shows a fractional bandwidth of more than 27%. The PA draws 115mA from a 3.3-V supply.
Full Activation of the Platelet-derived Growth Factor β-Receptor Kinase Involves Multiple Events*

Activation of receptor tyrosine kinases is thought to involve ligand-induced dimerization, which promotes receptor transphosphorylation and thereby increases the receptor’s phosphotransferase activity. We used two platelet-derived growth factor β-receptor (β-PDGFR) mutants to identify events that are required for full engagement (autophosphorylation and activation of the kinase activity) of the β-PDGFR kinase. The F79/81 receptor (Tyr to Phe substitution at 579 and 581 in the juxtamembrane domain of the receptor) was capable of only very modest ligand-dependent autophosphorylation and also failed to associate with numerous SH2 domain-containing proteins. Furthermore, stimulation with platelet-derived growth factor (PDGF) did not increase the kinase activity of the F79/81 mutant toward exogenous substrates. However, the F79/81 receptor had basal kinase activity and could be artificially stimulated by incubation with ATP. Because the low kinase activity of the F857 mutant (Tyr to Phe substitution at 857 in the putative activation loop) could not be increased by incubation with ATP, failure to phosphorylate Tyr-857 may be the reason why the F79/81 mutant has low kinase activity. Surprisingly, the F857 mutant underwent efficient PDGF-dependent autophosphorylation. Thus the PDGF-dependent increase in the kinase activity of the receptor is not required for autophosphorylation. We conclude that full activation of the β-PDGFR kinase requires at least two, apparently distinct events.
Treatment of periodontal intrabony defects with demineralized freeze-dried bone allograft in combination with platelet-rich plasma: a comparative clinical trial.

BACKGROUND The aim of the present randomized, double-masked, clinical trial was to compare platelet-rich plasma (PRP) combined with a demineralized freeze-dried bone allograft (DFDBA) to DFDBA mixed with a saline solution in the treatment of human intrabony defects. METHODS Sixty interproximal intrabony osseous defects in 60 healthy, non-smoking subjects diagnosed with chronic periodontitis were treated in this study. Thirty subjects each were randomly assigned to the test group (PRP + DFDBA) or the control group (DFDBA + saline). Clinical and radiographic measurements were made at baseline and at the 12-month evaluation. RESULTS Compared to baseline, the 12-month results indicated that both treatment modalities resulted in significant changes in all clinical parameters (gingival index, bleeding on probing, probing depth, clinical attachment level, and gingival recession; P <0.001) and radiographic parameters (hard tissue fill and bone depth reduction; P <0.001). However, the test group exhibited statistically significantly greater changes compared to the control group in probing depth reduction (4.3 +/- 1.7 mm versus 2.6 +/- 2.2 mm; P <0.05) and clinical attachment gain (3.5 +/- 2.1 mm versus 2.3 +/- 2.4 mm; P <0.001). CONCLUSIONS Treatment with a combination of PRP and DFDBA led to a significantly greater clinical improvement in intrabony periodontal defects compared to DFDBA with saline. No statistically significant differences were observed in the hard tissue response between the two treatment groups, which confirmed that PRP had no effect on hard tissue fill or gain in new hard tissue formation.
The global meaning structure of the emotion domain: investigating the complementarity of multiple perspectives on meaning

The hypotheses about the overall structure of the emotion domain as proposed by the three main theoretical approaches in psychology is investigated. As predicted by the componential emotion approach, it is found that features from all emotion components contribute universally to the meaning of emotion terms. The prediction of the dimensional approach that emotion information can be represented adequately by a low-dimensional structure is confirmed. The four dimensions of valence, power, arousal, and novelty emerge in that order of importance. A categorical representation of the data revealed the four major basic clusters of joy, sadness, fear, and anger and two smaller clusters of surprise and compassion. Moreover, it is observed that 82.1% of the emotion terms across the 34 samples could be correctly classified in one of the 24 a priori emotion term categories on the basis of their feature profiles.
Increased Curvature of the Tentorium Cerebelli in Idiopathic Intracranial Hypertension

BACKGROUND AND PURPOSE: Transverse sinus effacement is detectable on MRV examinations in almost all patients with idiopathic intracranial hypertension. This effacement of the transverse sinus is presumed to be mediated by elevation of intracranial pressure, resulting in compression and inward collapse of the dural margins of the sinus. We sought to establish whether supratentorial broad-based downward deformity of the tentorium might explain transverse sinus effacement in idiopathic intracranial hypertension. MATERIALS AND METHODS: MRV examinations of 53 adult patients with idiopathic intracranial hypertension were reviewed retrospectively and compared with 58 contemporaneously acquired controls. The curvature of the tentorium with reference to a line connecting the transverse sinus laterally with the confluence of the tentorial leaves medially was calculated as a segment of a circle. The height and area of the segment and the angle subtended by the midpoint of the tentorium from the falx were calculated. RESULTS: The height and area of the segment described by the chord connecting the transverse sinus with the apex of the tentorial confluence and subtended midtentorial angle were greater in the idiopathic intracranial hypertension group; this finding supports the hypothesis that increased tentorial bowing is present in idiopathic intracranial hypertension. CONCLUSIONS: Increased bowing of the tentorium in patients with idiopathic intracranial hypertension compared with controls is a new observation, lending itself to new hypotheses on the nature and localization of elevated intracranial pressure in idiopathic intracranial hypertension. Bowing of the tentorium may play a part in distorting the contour of the transverse sinuses, resulting, at least in part, in the effacement of the transverse sinuses in idiopathic intracranial hypertension.
The complete mitochondrial genome of Pimephales promelas (Cypriniformes: Cyprinidae)

Abstract The fathead minnow, Pimephales promelas, is an ecological important fish distributed across North America. In this study, we firstly assembled the complete mitochondrial genome of P. promelas. The mitogenome is 16 709 bp in length, including 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, 2 ribosomal RNA (rRNA) genes, and 2 non-coding regions. The gene content and order is in accord with the common vertebrate form. ATG acts as the start codon for all PCGs except cytochrome c oxidase subunit I (COXI), which has GTG as a start codon. The nucleotide base composition of H-strand is 29.2% A, 27.9% T, 25.9% C, and 17.0% G. The complete mitochondrial genome data would be useful for further studies of reproduction, development, and adaptive evolution of P. promelas.
The complete chloroplast genome sequence of Ledebouriella seseloides (Hoffm.) H. Wolff

Abstract Ledebouriella seseloides (Hoffm.) H.Wolff is a traditional medicinal herb belonging to Apiaceae family, whose dried roots and rhizomes have been used as traditional medicine in East Asian countries. The complete chloroplast genome of L. seseloides was obtained by de novo assembly using the small amount of whole genome sequencing data. The chloroplast genome of L. seseloides was 147 880 bp in length, which consisted of large single copy region (93 222 bp), small single copy region (17 324 bp), and a pair of inverted repeat regions (18 667 bp). The overall GC contents of the chloroplast genome were 37.5%. A total of 113 genes were annotated, which included 79 protein-coding genes, 30 tRNA genes, and four rRNA genes. Phylogenetic analysis with the reported chloroplast genomes revealed that L. seseloides is most closely related to Petroselinum crispum (parsley), an herb widely used in cooking.