Miracle-dz/UniFAR-FTUs huggingface dataset:
A Novel Packets Transmission Scheme Based on Software Defined Open Wireless Platform

The IEEE 802.11-2012, known as wireless-fidelity, offers a rich set of physical layer (PHY) features supported by advanced media access control (MAC) mechanisms. The use of off-the-shelf commercial 802.11 network interface card based (NIC-based) platforms constitutes an inexpensive prototyping approach based on reprogramming the cards software drivers. Besides, the commercial 802.11 NIC-based platform performs the functions of the MAC layer and PHY layer, respectively, by way of the firmware in the networking card and the software-driver running on the host computer, the former of which carries out the time-critical functions (Low MAC and PHY) while the latter serves the time-tolerant functions (High MAC). However, the maintenance of the cards produced in this way turns out quite troublesome. Therefore, based on a mixed real-time software-hardware architecture, i.e., a software defined open wireless platform, a novel packets transmission scheme is proposed in this paper in order to overcome the limitations of the NIC-based platform so that it becomes fully flexible and re-configurable. Furthermore, the novel scheme consists of three parts. First, a preliminary scheme is designed as follows: shift the hard-coded Low MAC and the PHY to the user space, then carry out the High MAC in the kernel space, and then combine the High MAC with the Low MAC via the Netlink. Second, based on preliminary scheme, the sending packets (i.e., the MAC frame) are reorganized in a lightweight way and the packets’ completeness and correctness are validated with experiments. Third, an M/M/1 model is exploited to create a packets transmission ring for optimizing the preliminary scheme. And the experimental results of the packets transmission concerned have proved the above-mentioned novel scheme outperforms the traditional one (i.e., the NIC-based platform) in terms of the system overhead and the number of packets sent in unit time.
Picture-perfect streaming over the Internet: is there hope?

Quality of service in streaming of continuous media over the Internet is poor, which is partly due to variations in delays, bandwidth limitations, and packet losses. Although continuous media applications can tolerate some missing data, non-recoverable information loss degrades these applications' QoS. Consequently, a number of application areas (e.g., those related to the entertainment industry) have backed away from streaming of their content over the Internet. Inability to control the resulting visual and auditory quality of the resulting streamed presentation is an important reason for such a trend. We believe that this trend can be reversed. To this end, our work focuses on providing high-quality streaming through the exploitation of multiple paths existing in the network. By high quality, we mean with significant bandwidth requirements, of relatively long duration, and without information loss or hiccups in data delivery. In this article we present evidence that multi-path streaming is a promising approach.
Platelets Guide Leukocytes to Their Sites of Extravasation

Effective immune responses require the directed migration of leukocytes from the vasculature to the site of injury or infection. How immune cells “find” their site of extravasation remains largely obscure. Here, we identified a previously unrecognized role of platelets as pathfinders guiding leukocytes to their exit points in the microvasculature: upon onset of inflammation, circulating platelets were found to immediately adhere at distinct sites in venular microvessels enabling these cellular blood components to capture neutrophils and, in turn, inflammatory monocytes via CD40-CD40L-dependent interactions. In this cellular crosstalk, ligation of PSGL-1 by P-selectin leads to ERK1/2 MAPK-dependent conformational changes of leukocyte integrins, which promote the successive extravasation of neutrophils and monocytes to the perivascular tissue. Conversely, blockade of this cellular partnership resulted in misguided, inefficient leukocyte responses. Our experimental data uncover a platelet-directed, spatiotemporally organized, multicellular crosstalk that is essential for effective trafficking of leukocytes to the site of inflammation.
Preoperative Breast Magnetic Resonance Imaging Use by Breast Density and Family History of Breast Cancer.

BACKGROUND Use of preoperative breast magnetic resonance imaging (MRI) among women with a new breast cancer has increased over the past decade. MRI use is more frequent in younger women and those with lobular carcinoma, but associations with breast density and family history of breast cancer are unknown. MATERIALS AND METHODS Data for 3075 women ages >65 years with stage 0-III breast cancer who underwent breast conserving surgery or mastectomy from 2005 to 2010 in the Breast Cancer Surveillance Consortium were linked to administrative claims data to assess associations of preoperative MRI use with mammographic breast density and first-degree family history of breast cancer. Multivariable logistic regression estimated adjusted odds ratios (OR) and 95% confidence intervals (95% CI) for the association of MRI use with breast density and family history, adjusting for woman and tumor characteristics. RESULTS Overall, preoperative MRI use was 16.4%. The proportion of women receiving breast MRI was similar by breast density (17.6% dense, 16.9% nondense) and family history (17.1% with family history, 16.5% without family history). After adjusting for potential confounders, we found no difference in preoperative MRI use by breast density (OR = 0.95 for dense vs. nondense, 95% CI: 0.73-1.22) or family history (OR = 0.99 for family history vs. none, 95% CI: 0.73-1.32). CONCLUSIONS Among women aged >65 years with breast cancer, having dense breasts or a first-degree relative with breast cancer was not associated with greater preoperative MRI use. This utilization is in keeping with lack of evidence that MRI has higher yield of malignancy in these subgroups.
RoadTracer: Automatic Extraction of Road Networks from Aerial Images

Mapping road networks is currently both expensive and labor-intensive. High-resolution aerial imagery provides a promising avenue to automatically infer a road network. Prior work uses convolutional neural networks (CNNs) to detect which pixels belong to a road (segmentation), and then uses complex post-processing heuristics to infer graph connectivity. We show that these segmentation methods have high error rates because noisy CNN outputs are difficult to correct. We propose RoadTracer, a new method to automatically construct accurate road network maps from aerial images. RoadTracer uses an iterative search process guided by a CNN-based decision function to derive the road network graph directly from the output of the CNN. We compare our approach with a segmentation method on fifteen cities, and find that at a 5% error rate, RoadTracer correctly captures 45% more junctions across these cities.
Astrocyte‐derived lipocalin‐2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia

Lipocalin‐2 (LCN2) has diverse functions in multiple pathophysiological conditions; however, its pathogenic role in vascular dementia (VaD) is unknown. Here, we investigated the role of LCN2 in VaD using rodent models of global cerebral ischemia and hypoperfusion with cognitive impairment and neuroinflammation. Mice subjected to transient bilateral common carotid artery occlusion (tBCCAo) for 50 min showed neuronal death and gliosis in the hippocampus at 7 days post‐tBCCAo. LCN2 expression was observed predominantly in the hippocampal astrocytes, whereas its receptor was mainly detected in neurons, microglia, and astrocytes. Furthermore, Lcn2‐deficient mice, compared with wild‐type animals, showed significantly weaker CA1 neuronal loss, cognitive decline, white matter damage, blood–brain barrier permeability, glial activation, and proinflammatory cytokine production in the hippocampus after tBCCAo. Lcn2 deficiency also attenuated hippocampal neuronal death and cognitive decline at 30 days after unilateral common carotid artery occlusion (UCCAo). Furthermore, intracerebroventricular (i.c.v) injection of recombinant LCN2 protein elicited CA1‐neuronal death and a cognitive deficit. Our studies using cultured glia and hippocampal neurons supported the decisive role of LCN2 in hippocampal neurotoxicity and microglial activation, and the role of the HIF‐1α–LCN2–VEGFA axis of astrocytes in vascular injury. Additionally, plasma levels of LCN2 were significantly higher in patients with VaD than in the healthy control subjects. These results indicate that hippocampal damage and cognitive impairment are mediated by LCN2 secreted from reactive astrocytes in VaD.
A Proposal of an Efficient Traffic Matrix Estimation Under Packet Drops

Traffic matrix (TM) estimation has been extensively studied for decades. Although conventional estimation techniques assume that traffic volumes are unchanged between origins and destinations, packets are often discarded on a path due to traffic burstiness, silent failures, etc. This paper proposes a novel TM estimation method that works correctly even under packet drops. The method is established on a Boolean fault localization technique; the technique requires fewer counters though it only determines whether each link is healthy. This paper extends the Boolean technique so as to deal with traffic volumes with error bounds just by a small number of counters. Along with submodular optimization for the minimum counter placement, we evaluate our method with real network datasets.
Detection of Aspergillus fumigatus in Blood Samples from Critically Ill Patients in Intensive Care Units by Use of the SeptiFast Assay

ABSTRACT We retrospectively analyzed the performance and relevance of the SeptiFast assay in detecting Aspergillus fumigatus DNA in whole blood samples from 38 critically ill intensive care unit (ICU) patients with probable or proven invasive aspergillosis (IA) and 100 ICU patients without IA. The assay exhibited 66% sensitivity, 98% specificity, a 93% positive predictive value, and an 88% negative predictive value. A. fumigatus DNAemia was associated with poor outcome.
Characterizing Performance and Energy-Efficiency of the RAMCloud Storage System

Most large popular web applications, like Facebook and Twitter, have been relying on large amounts of in-memory storage to cache data and offer a low response time. As the main memory capacity of clusters and clouds increases, it becomes possible to keep most of the data in the main memory. This motivates the introduction of in-memory storage systems. While prior work has focused on how to exploit the low-latency of in-memory access at scale, there is very little visibility into the energy-efficiency of in-memory storage systems. Even though it is known that main memory is a fundamental energy bottleneck in computing systems (i.e., DRAM consumes up to 40% of a server's power). In this paper, by the means of experimental evaluation, we have studied the performance and energy-efficiency of RAMCloud - a well-known in-memory storage system. We reveal that although RAMCloud is scalable for read-only applications, it exhibits non-proportional power consumption. We also find that the current replication scheme implemented in RAMCloud limits the performance and results in high energy consumption. Surprisingly, we show that replication can also play a negative role in crash-recovery.
Prostate cancer high dose-rate brachytherapy: review of evidence and current perspectives

ABSTRACT Introduction: Patients with intermediate to high risk disease (prostate specific antigen (PSA) ≥ 10, Gleason score ≥ 7, or clinical stage ≥ T2b) suffer from poorer long-term biochemical control (freedom from an increasing prostate specific antigen level) when treated with external beam radiation (EBRT) alone. In order to improve biochemical control while limiting long-term complications, brachytherapy has been incorporated into radiotherapy treatment, either alone or in combination with EBRT. Areas covered: Current literature regarding the use of high dose-rate (HDR) brachytherapy for localized prostate cancer, including as a boost and monotherapy. The efficacy and toxicities of various approaches are evaluated including comparisons to low dose-rate (LDR) brachytherapy. Expert commentary: Prostate HDR brachytherapy has higher conformality than EBRT, potentially improving the therapeutic ratio by allowing higher doses per fraction to tumor cells. The improved biochemical control shown in trials have resulted in EBRT plus brachytherapy to be included as a standard treatment option supported by the NCCN and ASCO guidance documents for intermediate to high risk prostate cancer.
Surgical closure of patent ductus arteriosus in extremely low birth weight infants weighing less than 750 grams.

BACKGROUND Patent ductus arteriosus (PDA) occurs more frequently in premature infants. Depending on the degree of prematurity, these children often have other serious comorbidities that could have a significant impact on surgical outcome. AIM This study aimed to evaluate the clinical results of surgical ligation of PDA in extremely low body weight preterm infants with birth weight below 750 g, and to identify risk factors of mortality. METHODS A total of 31 preterm infants with birth weight below 750 g and significant PDA were operated between 2006 and 2016 through posterolateral thoracotomy (n = 16) or with the use of video-assisted thoracoscopic method (n = 15). Mean weight at the time of surgery was 750.8 ± 104.7 g. The gestational age ranged from 22 to 32 weeks. Data were retrospectively analysed, and prospective 100% follow-up was performed. RESULTS In-hospital mortality was 25.8% (n = 8). The type of surgery had no influence on the results. During the follow-up period lasting 5.2 ± 2.5 years, two other patients died. One-year and five-year probability of survival was 77.4% and 74.2%, respectively. The predominant cause of death was acute heart failure. All patients with preoperative renal dysfunction died in the postoperative period. Moreover, Cox regression analysis revealed renal dysfunction as an independent risk factor of early death. CONCLUSIONS Preterm infants with birth weight less than 750 g and significant PDA are highly challenging patients. Despite the recent advances in perioperative management with neonates, surgery is still associated with a high early mortality rate irrespective of the applied method.
Minimally-Invasive Neural Interface for Distributed Wireless Electrocorticogram Recording Systems

This paper presents a minimally-invasive neural interface for distributed wireless electrocorticogram (ECoG) recording systems. The proposed interface equips all necessary components for ECoG recording, such as the high performance front-end integrated circuits, a fabricated flexible microelectrode array, and wireless communication inside a miniaturized custom-made platform. The multiple units of the interface systems can be deployed to cover a broad range of the target brain region and transmit signals via a built-in intra-skin communication (ISCOM) module. The core integrated circuit (IC) consists of 16-channel, low-power push-pull double-gated preamplifiers, in-channel successive approximation register analog-to-digital converters (SAR ADC) with a single-clocked bootstrapping switch and a time-delayed control unit, an ISCOM module for wireless data transfer through the skin instead of a power-hungry RF wireless transmitter, and a monolithic voltage/current reference generator to support the aforementioned analog and mixed-signal circuit blocks. The IC was fabricated using 250 nm CMOS processes in an area of 3.2 × 0.9 mm2 and achieved the low-power operation of 2.5 µW per channel. Input-referred noise was measured as 5.62 µVrms for 10 Hz to 10 kHz and ENOB of 7.21 at 31.25 kS/s. The implemented system successfully recorded multi-channel neural activities in vivo from a primate and demonstrated modular expandability using the ISCOM with power consumption of 160 µW.
HIV-1 Subtypes and 5′LTR-Leader Sequence Variants Correlate with Seroconversion Status in Pumwani Sex Worker Cohort

Within the Pumwani sex worker cohort, a subgroup remains seronegative, despite frequent exposure to HIV-1; some of them seroconverted several years later. This study attempts to identify viral variations in 5′LTR-leader sequences (5′LTR-LS) that might contribute to the late seroconversion. The 5′LTR-LS contains sites essential for replication and genome packaging, viz, primer binding site (PBS), major splice donor (SD), and major packaging signal (PS). The 5′LTR-LS of 20 late seroconverters (LSC) and 122 early seroconverters (EC) were amplified, cloned, and sequenced. HelixTree 6.4. 3 was employed to classify HIV subtypes and sequence variants based on seroconversion status. We find that HIV-1 subtypes A1.UG and D.UG were overrepresented in the viruses infecting the LSC (P < 0.0001). Specific variants of PBS (Pc < 0.0001), SD1 (Pc < 0.0001), and PS (Pc < 0.0001) were present only in the viral population from EC or LSC. Combinations of PBS [PBS-2 (Pc < 0.0001) and PBS-3 (Pc < 0.0001)] variants with specific SD sequences were only seen in LSC or EC. Combinations of A1.KE or D with specific PBS and SD variants were only present in LSC or EC (Pc < 0.0001). Furthermore, PBS variants only present in LSC co-clustered with PBS references utilizing tRNAArg; whereas, the PBS variants identified only in EC co-clustered with PBS references using tRNALys,3 and its variants. This is the first report that specific PBS, SD1, and PS sequence variants within 5′LTR-LS are associated with HIV-1 seroconversion, and it could aid designing effective anti-HIV strategies.
TRANSFORMATION OF STREPTOCOCCI TO STREPTOMYCIN RESISTANCE

Perry, Dennis (Northwestern University Medical School, Chicago, Ill.) and Hutton D. Slade. Transformation of streptococci to streptomycin resistance. J. Bacteriol. 83:443–449. 1962. —A total of 43 strains of streptococci, belonging to serological groups A, B, C, D, E, F, G, H, K, L, M, N, O, and Q, and three ungroupable strains were exposed to deoxyribonucleic acid (DNA) extracted from streptomycin-resistant streptococci belonging to groups A, C, D, G, H, and ungroupable strains. Transformation to streptomycin resistance was obtained with streptococci belonging to groups F, H, and O and a serologically unclassifiable streptococcus. The transformable streptococci incorporated DNA from both homologous and heterologous groups and strains of streptococci. Certain strains within a group served as DNA donors but not as DNA recipients, and certain strains served as DNA donors for some strains but not for others. Even within an individual group, not all strains were transformable. The number of transformants was influenced by the source of DNA and the DNA recipient strain used. Substances which affect cell permeability did not enable transformation to occur. Radioisotope studies with P32-labelled DNA showed that nontransformable strains incorporated amounts of DNA comparable to the transformable strains.
Understanding how and why audits work: protocol for a realist review of audit programmes to improve hospital care

Introduction Many types of audits are commonly used in hospital care to promote quality improvements. However, the evidence on the effectiveness of audits is mixed. The objectives of this proposed realist review are (1) to understand how and why audits might, or might not, work in terms of delivering the intended outcome of improved quality of hospital care and (2) to examine under what circumstances audits could potentially be effective. This protocol will provide the rationale for using a realist review approach and outline the method. Methods and analysis This review will be conducted using an iterative four-stage approach. The first and second steps have already been executed. The first step was to develop an initial programme theory based on the literature that explains how audits are supposed to work. Second, a systematic literature search was conducted using relevant databases. Third, data will be extracted and coded for concepts relating to context, outcomes and their interrelatedness. Finally, the data will be synthesised in a five-step process: (1) organising the extracted data into evidence tables, (2) theming, (3) formulating chains of inference from the identified themes, (4) linking the chains of inference and formulating CMO configurations and (5) refining the initial programme theory. The reporting of the review will follow the ‘Realist and Meta-Review Evidence Synthesis: Evolving Standards’ (RAMESES) publication standards. Ethics and dissemination This review does not require formal ethical approval. A better understanding of how and why these audits work, and how context impacts their effectiveness, will inform stakeholders in deciding how to tailor and implement audits within their local context. We will use a range of dissemination strategies to ensure that findings from this realist review are broadly disseminated to academic and non-academic audiences. PROSPERO registration number CRD42016039882.
The MUSCIMA++ Dataset for Handwritten Optical Music Recognition

Optical Music Recognition (OMR) promises to make accessible the content of large amounts of musical documents, an important component of cultural heritage. However, the field does not have an adequate dataset and ground truth for benchmarking OMR systems, which has been a major obstacle to measurable progress. Furthermore, machine learning methods for OMR require training data. We design and collect MUSCIMA++, a new dataset for OMR. Ground truth in MUSCIMA++ is a notation graph, which our analysis shows to be a necessary and sufficient representation of music notation. Building on the CVC-MUSCIMA dataset for staffline removal, the MUSCIMA++ dataset v1.0 consists of 140 pages of handwritten music, with 91254 manually annotated notation symbols and 82247 explicitly marked relationships between symbol pairs. The dataset allows training and directly evaluating models for symbol classification, symbol localization, and notation graph assembly, and indirectly musical content extraction, both in isolation and jointly. Open-source tools are provided for manipulating the dataset, visualizing the data and annotating further, and the data is made available under an open license.
Cross-Layer Design of Wireless Multihop Backhaul Networks With Multiantenna Beamforming

A cross-layer design approach is considered for joint routing and resource allocation for the physical (PHY) and the medium access control (MAC) layers in multihop wireless backhaul networks. The access points (APs) are assumed to be equipped with multiple antennas capable of both transmit and receive beamforming. A nonlinear optimization problem is formulated, which maximizes the fair throughput of the APs in the network under the routing and the PHY/MAC constraints. Dual decomposition is employed to decouple the original problem into smaller subproblems in different layers, which are coordinated by the dual prices. The network layer subproblem can be solved in a distributed manner and the PHY layer subproblem in a semidistributed manner. To solve the PHY layer subproblem, an iterative minimum mean square error (IMMSE) algorithm is used with the target link signal-to-interference-and-noise-ratio (SINR) set dynamically based on the price generated from the upper layers. A scheduling heuristic is also developed, which improves the choice of the transmission sets over time. Simulation results illustrate the efficacy of the proposed cross-layer design.