Miracle-dz/UniFAR-FTUs huggingface dataset:
Growth arrest of HPV-positive cells after histone deacetylase inhibition is independent of E6/E7 oncogene expression.

Inhibitors of histone deacetylase (HDAC) are capable of arresting growth in cervical carcinoma cells in the G1 phase of the cell cycle. Although HPV E6/E7 mRNA steady-state levels appeared to be constant after prolonged treatment, time-course experiments revealed that viral transcription was transiently down-regulated between 7-10 h prior to cdk2 suppression. To test whether transitory suppression was a prerequisite for the biological outcome after HDAC inhibition, we took advantage of two immortalized human keratinocyte cell lines in which E6/E7 oncogene expression was controlled by different regulatory regions. After treatment with sodium butyrate (NaB) or trichostatin A (TSA), HPV16 upstream regulatory region (URR)-directed transcription was down-regulated, showing kinetics similar to those in cervical carcinoma cells. In contrast, beta-actin promoter controlled E6/E7 transcription was even temporarily increased and finally declined to levels initially detected in the untreated controls. Both cell lines, however, were arrested in G1 and showed complete suppression of cdk2 activity that was preceded by a strong up-regulation of the cdk2 inhibitors p21(CIP1) and p27(KIP1). These results demonstrate that growth of HPV16/18-positive cells can be arrested by HDAC inhibitors despite ongoing HPV transcription and thus independently of any potential position effects uncoupling URR-directed gene expression by adjacent cellular promoters or by downstream 3'-polyadenylation sites after viral integration into the host genome during multistep carcinogenesis.
Consuming cool: Behind the unemotional mask

Purpose – We use data from the United States and Finland, a literature review, and historical analysis to understand the concept and role of cool within global consumer culture. Methodology/approach – This is a conceptual review and qualitative analysis of data from depth interviews, journals, and online discussion groups in two U.S. locations and one Finnish location. Findings – Cool is a slang word connoting a certain style that involves masking and hiding emotions. As cool diffuses we find that it is both distilled and diluted. The concept itself has also evolved. What was once a low-profile means of survival and later a youthful rebellious alternative to class-based status systems has become commoditized. Research limitations/implications – The study has been conducted in two cultures with a limited range of ages thought to be most susceptible to the appeal of being cool. Practical limitations/implications – Marketers may not yet have exploited cool as effectively as they have exploited sex, but mainstream consumers now look for cool in the marketplace more than within themselves. The result is a continuous race to offer the next cool thing. Originality/value of chapter – It is argued that coolness is a new status system largely replacing social class, especially among the young.
Decrypting the ciphertexts of RSA cryptosystem with ciphering function

The RSA is based on a trapdoor one-way function which is easy to compute but is most hard to revert without knowing the trapdoor. A cryptanalysis, presented in this paper, consists in finding a new decrypting key which plays the same role of the original trapdoor. To find this new decrypting key we must seek the composition maximum degree of the ciphering function in a given modulus N. This maximum degree (d_max) is obtained by applying the ciphering function to a restricted set of residues in the modulus N. We then define the new decrypting key by (ed_max). Thanks to this new key, we can decrypt any ciphertext for a given modulus. The interest of this cryptanalysis, contrary to factorization, is that the search time of the decrypting key is independent from the modulus size.
Collaborative Response Generation in Planning Dialogues

In collaborative planning dialogues, the agents have different beliefs about the domain and about each other; thus, it is inevitable that conflicts arise during the planning process. In this paper, we present a plan-based model for response generation during collaborative planning, based on a recursive Propose-Evaluate-Modify framework for modeling collaboration. We focus on identifying strategies for content selection when 1) the system initiates information-sharing to gather further information in order to make an informed decision about whether to accept a proposal from the user, and 2) the system initiates collaborative negotiation to negotiate with the user to resolve a detected conflict in the user's proposal. When our model determines that information-sharing should be pursued, it selects a focus of information-sharing from among multiple uncertainties that might be addressed, chooses an appropriate information-sharing strategy, and formulates a response that initiates an information-sharing subdialogue. When our model determines that conflicts must be resolved, it selects the most effective conflicts to address in resolving disagreement about the user's proposal, identifies appropriate justification for the system's claims, and formulates a response that initiates a negotiation subdialogue.
Least-squares adaptive lattice and transversal filters: A unified geometric theory

A unified theory is presented to characterize least-squares adaptive filters, in either lattice or transversal-filter form, for nonstationary processes. The derivations are based upon a geometric formulation of least-squares estimation and on the concept of displacement rank. A few basic geometric relations are shown to underlie the various algorithms. Insights into the fundamental concepts that unify lattice- and transversal-filter approaches to least-squares adaptive filters are also given. The general results are illustrated by applications to the so-called "pre-windowed" and "growing-memory covariance" formulations of the deterministic least-squares problem.
Understanding nonsuicidal self-injury : origins, assessment, and treatment

Nonsuicidal self-injury (NSSI) is the deliberate damaging of one's own body tissue in the absence of any intent to die. Although reports of this behavior span centuries, reported instances of NSSI have increased dramatically over the last 20 years. Until now, there has been no authoritative book on the topic that evaluates why this behavior occurs and what evidence-based assessment and treatments are available. Editor Matthew K. Nock has compiled the first comprehensive overview of NSSI written by leading theorists, researchers, and clinicians in the field.Drawing upon the historical, biological, cognitive, behavioral, and interpersonal literature, the contributors help to provide answers to some key questions: How prevalent is NSSI? What is its history? Does it occur more frequently among youth? Among females? What influences its occurrence? And, most importantly, how can mental health professionals help those who self-injure? The book's contributors have created a monumental and accessible study of NSSI. "Understanding Nonsuicidal Self-Injury" is a must-have for both researchers and clinicians, including psychologists, psychiatrists, social workers, nurses, and all who wish to help those who struggle with this disturbing behavior.The book is suitable for researching psychologist, graduate psychology students, counseling psychologists, school psychologists, clinical psychologists; and other clinical mental health professionals, such as clinical social workers and psychiatrists, educators, parents.
GRADE: grading quality of evidence and strength of recommendations for diagnostic tests and strategies

aHolger J Schünemann professor, Department of Epidemiology, Italian National Cancer Institute Regina Elena, 00144 Rome, Italy and CLARITY Research Group, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada L8N 3Z5 andrew D oxman researcher, Norwegian Knowledge Centre for the Health Services, PO Box 7004, 0130 Oslo, Norway Jan Brozek research fellow, Department of Epidemiology, Italian National Cancer Institute Regina Elena, 00144 Rome, Italy Paul Glasziou professor, Centre for Evidence-Based Medicine, Department of Primary Health Care, University of Oxford, Oxford OX3 7LF Roman Jaeschke clinical professor, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5 Gunn e Vist researcher, Norwegian Knowledge Centre for the Health Services, PO Box 7004, 0130 Oslo, Norway John W Williams Jr professor, Department of Medicine, Duke University and Durham VA Medical Center, Durham, NC 27705, USA Regina Kunz associate professor, Basel Institute of Clinical Epidemiology, University Hospital Basel, Hebelstrasse 10, 4031 Basel, Switzerland Jonathan Craig associate professor, Screening and Test Evaluation Program, School of Public Health, University of Sydney, Department of Nephrology, Children’s Hospital at Westmead, Sydney, Australia In this fourth article of the five part series, we describe how guideline developers are using GRADE to rate the quality of evidence and move from evidence to a recommendation for diagnostic tests and strategies. Although recommendations on diagnosis share the fundamental logic of recommendations for other interventions, they present unique challenges. We will describe why guideline panels should be cautious when they use evidence of the accuracy of tests (“test accuracy”) as the basis for recommendations and why evidence of test accuracy often provides low quality evidence for making recommendations.
Gibberellins Regulate Lateral Root Formation in Populus through Interactions with Auxin and Other Hormones[C][W]

This work shows that gibberellins in poplar repress lateral root formation through interactions with other hormones like auxin. Gibberellin integrates aerial and root development, where aerial growth inhibition and concomitant stimulation of root proliferation produces a smaller plant with lower demands on environmental resources and a root system that can actively explore the soil environment. The role of gibberellins (GAs) in regulation of lateral root development is poorly understood. We show that GA-deficient (35S:PcGA2ox1) and GA-insensitive (35S:rgl1) transgenic Populus exhibited increased lateral root proliferation and elongation under in vitro and greenhouse conditions, and these effects were reversed by exogenous GA treatment. In addition, RNA interference suppression of two poplar GA 2-oxidases predominantly expressed in roots also decreased lateral root formation. GAs negatively affected lateral root formation by inhibiting lateral root primordium initiation. A whole-genome microarray analysis of root development in GA-modified transgenic plants revealed 2069 genes with significantly altered expression. The expression of 1178 genes, including genes that promote cell proliferation, growth, and cell wall loosening, corresponded to the phenotypic severity of the root traits when transgenic events with differential phenotypic expression were compared. The array data and direct hormone measurements suggested crosstalk of GA signaling with other hormone pathways, including auxin and abscisic acid. Transgenic modification of a differentially expressed gene encoding an auxin efflux carrier suggests that GA modulation of lateral root development is at least partly imparted by polar auxin transport modification. These results suggest a mechanism for GA-regulated modulation of lateral root proliferation associated with regulation of plant allometry during the stress response.
What does it mean to be a learning support teacher? A life-history investigation of ten learning support teachers in the east-coast of Ireland

There has been a rapid expansion of the learning support (LS) teaching service in Ireland since 1999 with approximately one in fifteen primary-school teachers currently working as learning support teachers (LSTs). Although there is a small body of quantitative research on LS teaching, there are no qualitative studies on LSTs themselves. This gap in the research is unfortunate because of the importance of studying teachers’ lives and perspectives as a key to understanding teaching, a now well-established position in biographical research on education. Using life-history interviews within a social constructivist paradigm, this study investigates the identity and work practices of ten LSTs in primary schools in the east-coast of Ireland. The study is based on the assumption that valuable insights into the work and identity of LSTs can be gained by examining their views and beliefs and the discourses through which they understand themselves and their work. A combination of grounded theory and discourse analysis is used to examine the language they use to construct themselves as LSTs and the discourse of LS teaching. The evidence from the study shows that there is a recognisable way of using language and engaging in specific practices that can be described as a discourse of LS teaching. The LSTs are both constructors of and constructed by the discourse of LS teaching. Their accounts show that they perceived themselves, and believed others perceived them to be, different from mainstream class-teachers. Using the overarching concept of ‘difference’, three themes were distilled from the LSTs’ accounts and used to analyse the data: their craft knowledge, the teaching of reading and parenthood. Their accounts display a potent union of theory and practice which was guided by their professional craft knowledge. They presented themselves as expert teachers of reading, comfortably embracing different models, thereby displaying their multiple positions and the complexity of the reading process. Drawing on their experiences of parenthood they constructed an identity for themselves as teacher-parents and parent-teachers. The findings have implications for the provision of in-service and professional development for LSTs. If, as their accounts suggest, the discourse of LS teaching pushes LSTs and their pupils into marginalised positions, it is important to scrutinise this discourse so that the exclusionary assumptions underpinning it are explored. The insider perspectives gained from the life-history accounts offer worthwhile insights into the intuitive craft of teaching in general and the teaching of reading in particular.
Mindfully Eating Raisins Improves Negotiation Success: The Effect of Mindfulness on Negotiation Performance

Anecdotal evidence suggests that mindfulness, or open, non-judgmental awareness of the present moment, is important for negotiation performance. We find support for this prediction in four experiments using a variety of different mindfulness manipulations and both objective and subjective measures of negotiation performance. We also provide evidence that the effect of mindfulness on negotiation performance is partly mediated by reduced anxiety.
Effective local stereo matching by extended triangular interpolation

In this paper, we propose an effective local stereo matching method based on extended triangular interpolation. The whole image is covered with a triangular mesh by performing triangulation on a set of initial support points. Since the disparity interpolation in some areas is ineffective, especially in the triangle which appears across the boundaries of objects or is formed by initial matching outliers, we formulate a new matching model based on the Bayesian rule to address this challenge. In the model, we introduce the concept of the triangle's reliability, and utilize the disparity planes determined by the neighboring triangles as the Bayesian prior. With the model, the disparity interpolation can be effectively performed. Experiments on the standard stereo data sets show that the method is effective, especially in dealing with the boundaries of objects.
Selective rendering: computing only what you see

The computational requirements of a full physically-based global illumination solution are significant, currently precluding its solution on even a powerful modern PC in reasonable let alone real time. A key factor to consider if we are ever to achieve so-called "Realism in Real-Time", is that we are computing images for humans to look at. Although the human visual system is very good, it is by no means perfect. By understanding what the human does, or perhaps more importantly, does not see, enables us to save significant computation effort without any loss of perceptual quality of the resultant image. This paper describes the novel techniques of selective rendering which allow us to direct computational resources to those areas of high perceptual importance while avoiding computing any detail which will not be perceived by the viewer. Such selective rendering methods offer us the real possibility of achieving high fidelity graphics of complex scenes at interactive rates.
Spectral clustering and discriminant analysis for unsupervised feature selection

In this paper, we propose a novel method for unsupervised feature selection, which utilizes spectral clustering and discriminant analysis to learn the cluster labels of data. During the learning of cluster labels, feature selection is performed simultaneously. By imposing row sparsity on the transformation matrix, the proposed method optimizes for selecting the most discriminative features which better capture both the global and local structure of data. We develop an iterative algorithm to eﬀec-tively solve the optimization problem in our method. Experimental results on diﬀerent real-world data demonstrate the eﬀectiveness of the proposed method.
Exploring Web 2.0: The Impact of Digital Communications Technologies on Youth Relationships and Sociability

The recent and rapid increase of Internet culture and new communications technologies is one important facet of changes in contemporary social life. Understanding the multiple and complex nature of these changes is an important sociological question. This paper uses qualitative data gained through face-to-face interviews and technology-mediated interviews conducted with college-aged students to explore the ways in which Internet culture and digital socialization affect youth relationships and sociability. Previous research has suggested that the pervasive and intensive use of Internet in education, communication and entertainment may be leading to decreasing face-to-face interaction among youth. Other research focuses on how technology may also expand and transform sociability by allowing people to communicate with a wider and more diverse network of people. Due to the contradictory findings about the consequences of widespread use of Web 2.0 technology among youth, the goal of this research is to explore the depth of the effects that digital socialization has on youth relationships, sociability, connectivity, and identity formation.
Adaptive Modulation with Diversity Combining Based on Output-Threshold MRC

In this paper, we propose a combined adaptive modulation transmission and output threshold MRC diversity reception scheme for high spectral and power efficiency wireless transceiver design. The modulation constellation size and the number of combined diversity paths are jointly determined to achieve the highest spectral efficiency but with low combining complexity, given the fading channel conditions and the required error rate performance. We derive the statistics of the resulting output signal-to-noise ratio (SNR) and then use it to analyze the proposed system (i) performance in terms of outage probability and average bit error rate, (ii) complexity in terms of the average number of path estimation and the average number of combined paths, and (iii) spectral efficiency. Some selected numerical examples are finally presented and discussed to illustrate the tradeoff offered by this scheme.
Stevens Johnson Syndrome and Toxic Epidermal Necrolysis: Maternal and Foetal Outcomes in Twenty-Two Consecutive Pregnant HIV Infected Women

Introduction Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) form a spectrum of a rare and life-threatening cutaneous drug reaction. SJS/TEN in pregnancy poses largely unknown risk factors and outcomes for both the mother and foetus compared to the general population. Methods We conducted a study of consecutive pregnant women admitted to single tertiary referral centre in South Africa with SJS/TEN over a 3 year period. They were all managed by the same medical team using the same protocols. We evaluated their underlying illnesses, offending drugs and the course of pregnancy and outcomes to determine factors influencing maternal and foetal outcomes. Results We identified twenty-two women who developed SJS/TEN while pregnant, all of them HIV-infected. Their median age was 29 years. The majority 16/22 (73%) had SJS, the milder variant of the disease affecting < 10% body surface area. Nevirapine was the offending drug in 21/22 (95%) cases. All 22 of the mothers survived with 3/22 (14%) developing postpartum sepsis. Pregnancy outcomes were known in 18/22 women and 9/18 (50%) babies were delivered by caesarean section. There were 2 foetal deaths at 21 and 31 weeks respectively and both were associated with post-partum sepsis. Postnatal complications occurred in 5 cases, 3 involving the respiratory system and the other two being low birth weight deliveries. Eight placentae and one foetus were sent for histology and none showed macroscopic or microscopic features of SJS/TEN. On follow-up, only 12/20 children were tested for HIV at 6 weeks post-delivery and none of them were HIV-infected. All had received prophylactic ARVs including nevirapine. Conclusions TEN, the severe form of the disease, was associated with poorer foetal outcomes. SJS/TEN-associated mortality is not increased in HIV-infected pregnant women. Maternal SJS/TEN does not seem to commonly manifest in the foetus.
Recent Advances and Achievements in Nanomaterial-Based, and Structure Switchable Aptasensing Platforms for Ochratoxin A Detection

Aptamer-based bioreceptors that can easily adopt their surroundings have captured the attention of scientists from a wide spectrum of domains in designing highly sensitive, selective and structure switchable sensing assays. Through elaborate design and chemical functionalization, numerous aptamer-based assays have been developed that can switch their conformation upon incubation with target analyte, resulting in an enhanced output signal. To further lower the detection limits to picomolar levels, nanomaterials have attracted great interest in the design of aptamer-based sensing platforms. Associated to their unique properties, nanomaterials offer great promise for numerous aptasensing applications. This review will discuss current research activities in the aptasensing with typical example of detection of ochratoxin A (OTA). OTA, a secondary fungal metabolite, contaminates a variety of food commodities, and has several toxicological effects such as nephrotoxic, hepatotoxic, neurotoxic, teratogenic and immunotoxic activities. The review will introduce advances made in the methods of integrating nanomaterials in aptasensing, and will discuss current conformational switchable design strategies in aptasensor fabrication methodologies.