Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique

In this study, the principles of surface sensing of translation (SUnSET) were used to develop a nonradioactive method for ex vivo and in vivo measurements of protein synthesis (PS). Compared with controls, we first demonstrate excellent agreement between SUnSET and a [3H]phenylalanine method when detecting synergist ablation‐induced increases in skeletal muscle PS ex vivo. We then show that SUnSET can detect the same synergist ablation‐induced increase in PS when used in vivo (IV‐SUnSET). In addition, IV‐SUnSET detected food deprivation‐induced decreases in PS in the heart, kidney, and skeletal muscles, with similar changes being visualized with an immunohistochemical version of IV‐SUnSET (IV‐IHC‐SUnSET). By combining IV‐IHC‐SUnSET with in vivo transfection, we demonstrate that constitutively active PKB induces a robust increase in skeletal muscle PS. Furthermore, transfection with Ras homolog enriched in brain (Rheb) revealed that a PKB‐independent activation of mammalian target of rapamycin is also sufficient to induce an increase in skeletal muscle PS. Finally, IV‐IHC‐SUnSET exposed the existence of fiber type‐dependent differences in skeletal muscle PS, with PS in type 2B and 2X fibers being significantly lower than that in type 2A fibers within the same muscle. Thus, our nonradioactive method allowed us to accurately visualize and quantify PS under various ex vivo and in vivo conditions and revealed novel insights into the regulation of PS in skeletal muscle. —Goodman, C. A. , Mabrey, D. M. , Frey, J. W. , Miu, M. H. , Schmidt, E. K. , Pierre, P., Hornberger, T. A. Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique. FASEB J. 25, 1028–1039 (2011). www.fasebj. org
Securities and Exchange Board of India and the Regulation of the Indian Securities Market

Financial markets have an important relationship with economic development. Regulation has been acknowledged to enable the orderly functioning of the securities market. The Securities and Exchange Board of India (SEBI) is the regulator charged with the orderly functioning of the securities market in India, protect the interests of investors and ensure development of the securities market. Since the establishment of SEBI in 1992, the Indian securities market has grown enormously in terms of volumes, new products and financial services. The literature examining the role of SEBI in this growth and development is limited and somewhat dated. This paper supplements the existing literature by updating the developments in the securities markets over the years. It complements the extant literature by enhancing the framework for examining the adequacy of the institutional arrangements under SEBI and then by examining whether the statutory arrangements at SEBI’s disposal are adequate ensure a well functioning securities market. This paper would be an important first step for a more systematic evaluation of the contribution of SEBI to the working of the Indian securities market. This paper is a substantial revision and updated version of an earlier paper on this subject.
On the Need of SME Organizational Adaption to the International Business Environment: A Competence-Based Perspective

In our paper we challenge the common notion that small and medium sized enterprises (SMEs) have to adapt to the international business environment to be successful when acting in an international context. Although we believe in a need for certain adaption, we claim that the possibility that SME are to a certain extent able to proactively shape outer conditions is not adequately considered in literature. Therefore we ask how far SMEs in international business need to adapt to the environment to ensure a state of international competitiveness. We understand SMEs as open systems (Sanchez and Heene, 1996) and employ the Competence-based Theory of the Firm (CbTF) (Foss and Ishikawa, 2007; Freiling et al., 2008) as theoretical frame of reference for our conceptual paper. Thanks to its moderate voluntaristic nature, this theory allows considering both social embeddedness and managerial discretion of firms. Besides, this perspective takes into account internal developments as well as developments in the business environment. This is particularly useful to understand interaction processes with the environment that aim at accessing so-called ‘firm-addressable assets’. Firm-addressable assets explain the resource dependence of international SMEs on third-parties. However, backed by ‘absorptive capacity’ (Cohen and Levinthal, 1990), firm-addressable assets fuel internal processes of learning as well as resource and competence building. Moreover, CbTF allows for considering the role of certain categories of resources. Following service-dominant logic (SDL) (Vargo and Lusch, 2004), the distinction between ‘operand resources’ and ‘operant resources’ becomes a centerpiece of our argument: SMEs need to adapt to the environment due to resource constraints by operand resources and shape the environment primarily driven by operant resources. Our paper advances research in three ways: (1) we reinforce the concept of moderate voluntarism in this stream of research and challenge the predominantly deterministic view on SME environmental adaption; (2) we introduce a rather new theory (CbTF) and develop an understanding that features the managerial discretion of SME’s in international competition; (3) we depart from the quite unspecific notion that intangibles matter in case of proactive SME management and specify the resource categories in this realm with more explanatory power in this regard.
The Impact of Contract Manufacturing on Inventory Performance: An Examination of U.S. Manufacturing Industries

In recent years, a growing number of original equipment manufacturers (OEMs) have transferred their manufacturing processes to specialized firms, known as contract manufacturers. In so doing, contract manufacturers can reduce an OEM's production costs and provide OEMs with flexibility in the production process. We examine another potential reason for the use of contract manufacturing—the potential for efficiency gains from inventory reductions. Employing econometric models and data representing manufacturing industries in the USA, we provide statistical evidence that contract manufacturing can lead to lower industry-wide inventory levels, after controlling for other relevant factors. Key managerial implications are derived from the analysis.
Online Investors: What They Want, What They Do, and How Their Portfolios Perform

For 5,500 individual online investors we match survey records with recent trading data to investigate what they want, in terms of their stated objectives for investing, what they do, in terms of the broad investing strategies they employ, and how their portfolios perform in terms of risk, return, turnover, and diversification. Our results show that speculation is an important investment objective, and is related to a higher turnover of stocks and derivatives, as well as riskier returns. In contrast, while the proportion of individual online investors saving for retirement is relatively low, those who do have this as their objective display a lower turnover of stocks and hold less concentrated portfolios. Individual online investors rely strongly on technical analysis as an investing strategy, which goes hand in hand with a higher turnover of stocks and derivatives, more concentrated portfolios, lower returns, and higher risk. Finally, a large fraction of the individual online investors in our sample rely on their intuition as an investing strategy, which is associated with a higher turnover of stocks.
Influence Tactics Used by Information Services Project Managers

This case study explored the influence tactics used by successful information services project managers at Harley-Davidson. The participants were chosen via purposeful sampling for this study. Face-to-face interviews were conducted, which brought out some themes on the qualities needed to be successful as an information services project manager. The predominant skills sets included active listening, effective communication, relationship building and organization. The influence strategies primarily mentioned by the participants were consultation and bargaining, which was similar to what was found in the review of prior research. Other findings from this research included the challenges faced by project managers and the methods they use to overcome these obstacles, the participants’ definition of project success and failure, and their description of successful project managers. Although there were many similarities in the responses of the participants, there were some key differences that are noted in the findings section. All of the project managers spoke of the strong desire to deliver a product that met the customer’s expectations and needs.
Trade in Services: IT and Task Content

In this paper we investigate the determinants of the dramatic increase in services tradability focusing on the extensive margin of the phenomenon. We use balance sheet and firm-level service trade information over the period 1995-2005 provided by the National Bank of Belgium and we merge it with information on the evolution of information technology use and tasks performed by workers from the qualification and career survey provided by the BIBB-IAB. We show that technological change, measured either by the more intensive use of information technologies or by changes in the task content of jobs, has substantially contributed to the increase in the number of service-trading firms. Interestingly, we find evidence of a churning effect. While technological change has induced net entry into service trading, it has also increased the likelihood of both gross entry and exit of firms. Furthermore, our evidence suggests that due to the peculiar nature of services provision, the change in the tasks content of jobs is a better measure of technological change than the use of information technologies. Our results are robust to controlling for service trade liberalization and offshoring.
Learning Information Systems Engineering and Its Management from Experience of a Tiny Project through University-Industry Collaboration

We have developed a training course where both undergraduate students and engineers in industry collaboratively learn a construction of information systems through project-based learning. The project is composed of two to four students and a project manager from an IT company. They try to develop a tiny information system for real clients and users. Through this project, students develop communication skills to acquire the client's requirements. They are able to learn from several different companies' philosophies and engineering methodologies by observing multiple projects. Project managers from the IT industry can experience the difficulty of project management such as clarifying the project scope, balancing between delivery and quality, and problem- finding/solving in the project. Our experience showed that although projects are very small in scale, common problems that are similar to actual large-scale projects occurred, due to the students' lack of skills.
PKC phosphorylates GluA1-Ser831 to enhance AMPA receptor conductance

AMPA receptors mediate fast excitatory synaptic transmission in the brain, and are dynamically regulated by phosphorylation of multiple residues within the C-terminal domain. CaMKII phosphorylates Ser831 within the AMPA receptor GluA1 subunit to increase single channel conductance, and biochemical studies show that PKC can also phosphorylate this residue. In light of the discovery of additional PKC phosphorylation sites within the GluA1 C-terminus, it remains unclear whether PKC phosphorylation of Ser831 increases GluA1 conductance in intact receptors. Here, we report that the purified, catalytic subunit of PKC significantly increases the conductance of wild-type GluA1 AMPA receptors expressed in the presence of stargazin in HEK293T cells. Furthermore, the mutation GluA1-S831A blocks the functional effect of PKC. These findings suggest that GluA1 AMPA receptor conductance can be increased by activated CaMKII or PKC, and that phosphorylation at this site provides a mechanism for channel modulation via a variety of protein signaling cascades.
A 77GHz power amplifier design scheme for automotive radar

This paper presents a 77GHz, 16dBm, 13% PAE power amplifier. It is simulated in a 0.13um silicon-germanium technology with fT of 200GHz. The design technique is not the same as those which are used in traditional power amplifiers. All the matching structures are composed of short or open stubs and MIM capacitors. To get a higher output saturation power, breakdown voltage is also considered in bias circuit design.
Modeling Multichannel Home Video Demand in the U.S. Motion Picture Industry

The U.S. motion picture industry has become increasingly reliant on posttheatrical channel profits. Two often-cited drivers of these profits are cross-channel substitution among posttheatrical channels and seasonality in consumer preferences for any movie. The authors use a differentiated products version of the multiplicative competitive interaction model to investigate these two phenomena. They estimate the model using data from 2000 and 2001 on two posttheatrical channels in the U.S. market: purchase and rental home viewing channels. Contrary to expectations based on business press commentary, after controlling for seasonality and movie attributes, the authors find low cross-channel price and availability elasticity for both channels. To measure the extent of cross-channel cannibalization, they simulate a 28-day window of sequential release with either purchase or rental channel going first. They find that windowing reduces the sum of revenues across both channels, because more consumers choose to not purchase or rent when faced with older movies in their favored channel rather than to switch to the alternative channel with newer movies.
An information theoretic view of network management

We present an information theoretic framework for network management for recovery from nonergodic link failures. Building on recent work in the field of network coding, we describe the input-output relations of network nodes in terms of network codes. This very general concept of network behavior as a code provides a fundamental way to quantify essential management information as that needed to switch among different codes (behaviors) for different failure scenarios. We give bounds on the network management information needed for link failure recovery in various network connection problems, in terms of basic parameters such as the number of source processes and the number of links in a minimum source-receiver cut. This is the first paper to our knowledge that looks at network management for general connections.
Factors affecting customers’ decision for taking out bank loans: a case of Greek customers

The concept of loyalty has received much consideration from both academics and practitioners in various industries and is a predominant research topic in the banking industry. Identifying the factors that affect customers’ decision to take out a loan from a particular bank has become an essential asset for many banks in their effort to attract new customers and to maintain existing ones. The purpose of the present study is to identify factors that influence Greek customers’ decision to take out a loan from commercial banks. A number of variables (demographics, service quality and satisfaction) have been examined as potential factors influencing customers’ decision to take out a loan. A randomly selected sample of Greek citizens (n=277) was chosen in order to test our hypotheses. A questionnaire with self-determined scales was created after ensuring the instrument’s validity through confirmatory factor analysis. Logistic regression results show that personal marital status, customer service, shop design and interest rates are the most significant predictors of taking loans. Several managerial implications suggest bank managers should focus on giving loans to single individuals as well as change their interest rates policies by decreasing rates for all kinds of loans, especially housing loans.
Adjusting the Capital Asset Pricing Model for the Short-Run with Liquidity Proxies, While Accounting for Denials and Deceptions in Financial Markets

Abstract : William Sharpe s 1964 capital asset pricing model relies heavily on an accurate assessment of the asset s sensitivity to the broader market, termed . By modifying the classic approach to incorporate liquidity of the asset, designated ', short-term return estimates may be improved. Specifically, in this research, the limit order book is used as a short-term proxy for liquidity assessments. Unfortunately, precise data were unavailable to test: however, detailed realistic examples are outlined in order to explore both rationale and critiques of the adjusted model. In light of the adjusted CAPM, modern market conditions, such as the rise in both high-frequency trading and alternative trading systems, are investigated to determine their impact on the model and asset pricing. Parallels can be drawn to appreciate these implementation obstacles under such information operation paradigms as denial, deception, and counterdeception. These topics, the protection of critical information from leakage, as well as the advancement and detection of deliberate misinformation, are increasingly critical for asset pricing. Furthermore, in response to these implementation obstacles, short-term asset pricing research is explored under both the efficient and adaptive market hypotheses. In conclusion, the thesis offers policy makers and regulators recommendations and considerations for the evolving financial landscape.
Collision Detection Algorithm Based on Data Parallelism

Modern computing technology enters the era of parallel computing with the trend of sustainable and scalable parallelism. Single Instruction Multiple Data (SIMD) is an important way to go along with the trend. It is able to gather more and more computing ability by increasing the number of processor cores without the need of modifying the program. Meanwhile, in the field of scientific computing and engineering design, many computation intensive applications are facing the challenge of increasingly large amount of data. Data parallel computing will be an important way to further improve the performance of these applications. In this paper, we take the accurate collision detection in building information modeling as an example. We demonstrate a model for constructing a data parallel algorithm. According to the model, a complex object is decomposed into the sets of simple objects; collision detection among complex objects is converted into those among simple objects. The resulting algorithm is a typical SIMD algorithm, and its advantages in parallelism and scalability is unparalleled in respect to the traditional algorithms.
Colon cancer: morphology detected with barium enema examination versus histopathologic stage.

PURPOSE To determine the relationship between the morphology of colon carcinomas detected with barium enema examination and the cancer stage. MATERIALS AND METHODS Clinical, radiographic, endoscopic, surgical, and histopathologic findings were retrospectively reviewed in 152 patients with colon cancer detected with barium enema examination during a 2-year period. RESULTS Eighty-six patients (57%) had lesions in the rectum and sigmoid and descending colon, and 66 (43%) patients had lesions more proximally in the colon. Lesions on the right side of the colon were less likely to cause symptoms than those on the left side. Eighty-one patients (53%) had annular or semiannular lesions, 57 (38%) had polypoid lesions, and 14 (9%) had plaquelike or carpet lesions. Six patients (4%) had Dukes stage A lesions; 84 (55%), Dukes stage B lesions; 42 (28%), Dukes stage C lesions; and 20 (13%), Dukes stage D lesions. CONCLUSION Annular or semiannular carcinomas had higher rates of serosal invasion and lymph node metastasis than polypoid carcinomas, but the rates of liver metastases were comparable.
Fresh perspectives on customer experience

Purpose – The purpose of this paper is to provide directions for future research on: broadening the role of customers in customer experience; taking a practice-based approach to customer experience; and recognizing the holistic, dynamic nature of customer experience across all touch points and over time. Design/methodology/approach – The approach is conceptual identifying current gaps in research on customer experience. Findings – The findings include a set of research questions and research agenda for future research on customer experience. Originality/value – This research suggests fresh perspectives for understanding the customer experience which can inspire future research and advance theory and managerial practice.
Preparation and Application of Children Traffic Safety Awareness Questionnaire

Basing on previous literature and experimental research work,the construct of children traffic safety awareness was first defined.Furthermore,a preliminary questionnaire was prepared to measure children's traffic safety awareness.1 023 primary and middle school students from Nanjing,Changzhou and Nantong cities were chosen to complete Children Traffic Safety Awareness Questionnaire.Internal consistency reliability,split-half reliability,content validity,and construct-related validity were analyzed.The results show Children Traffic Safety Awareness Questionnaire contains 17 items and three dimensions,including traffic safety knowledge,traffic safety attitude and traffic safety behavior for choosing,the internal consistency reliability coefficient Cronbach α of scale is 0.892,and split-half reliability coefficient Spearman-Brown is 0.845,the results of confirmatory factor analysis indicate that the three-factor structure of children traffic safety awareness is best,the characteristic of children traffic safety awareness level is influenced by gender: the males' traffic safety awareness level was lower than that of females,age has no significant effects on level,and traffic safety knowledge level developing with age,while second grade junior middle school children show worst traffic safety awareness in six grades.