Miracle-dz/UniFAR-FTUs huggingface dataset:
Eosinophilic Esophagitis: Red on Microscopy, White on Endoscopy

Background/Aims: The presenting symptom of eosinophilic esophagitis, a chronic TH2-type inflammatory disease, is uniform dysphagia attacks. Histology reveals a dense mucosal infiltration with eosinophils. Unfortunately, endoscopic findings are often unremarkable or misleading. This study characterizes the endoscopic manifestations of eosinophilic esophagitis and analyzes the nature and clinical features of the frequently observed white alterations. Methods: Thirty adult patients (22 males, 8 females; mean age 40.6 years) with previously confirmed EE prospectively underwent a structured interview, physical examination, laboratory tests and upper endoscopy with histomorphometric examination of the esophageal mucosa. Results: On endoscopy, all patients showed mucosal abnormalities in the esophagus. Findings included an unspectacular loss of vascular pattern (93.3%) and white exudates (53.3%). Biopsies demonstrated significantly increased eosinophilia in the white exudates (108.4 vs. 14.0 cells/hpf). A significant correlation was found between white exudates and dysphagia frequency (<1 attack/week = 20%; >1 attack/ week = 70%). Conclusion: Eosinophilic esophagitis evokes at least 12 different signs resulting in an individually unique endoscopic pattern, but no disease-specific picture. White exudates correspond to foci of dense eosinophilic infiltration reflecting inflammatory activity and are associated with significantly more frequent dysphagia attacks. Both the lack of a typical endoscopic picture as well as the heterogeneity of the eosinophilic infiltration impede diagnosis.
Roles of STAT3 in Protein Secretion Pathways during the Acute-Phase Response

ABSTRACT The acute-phase response is characteristic of perhaps all infections, including bacterial pneumonia. In conjunction with the acute-phase response, additional biological pathways are induced in the liver and are dependent on the transcription factors STAT3 and NF-κB, but these responses are poorly understood. Here, we demonstrate that pneumococcal pneumonia and other severe infections increase expression of multiple components of the cellular secretory machinery in the mouse liver, including the endoplasmic reticulum (ER) translocon complex, which mediates protein translation into the ER, and the coat protein complexes (COPI and COPII), which mediate vesicular transport of proteins to and from the ER. Hepatocyte-specific mutation of STAT3 prevented the induction of these secretory pathways during pneumonia, with similar results observed following pharmacological activation of ER stress by using tunicamycin. These findings implicate STAT3 in the unfolded protein response and suggest that STAT3-dependent optimization of secretion may apply broadly. Pneumonia also stimulated the binding of phosphorylated STAT3 to promoter regions of secretion-related genes in the liver, supporting a direct role for STAT3 in their transcription. Altogether, these results identify a novel function of STAT3 during the acute-phase response, namely, the induction of secretory machinery in hepatocytes. This may facilitate the processing and delivery of newly synthesized loads of acute-phase proteins, enhancing innate immunity and preventing liver injury during infection.
The well-separated pair decomposition for balls

Given a real number $t>1$, a geometric $t$-spanner is a geometric graph for a point set in $\mathbb{R}^d$ with straight lines between vertices such that the ratio of the shortest-path distance between every pair of vertices in the graph (with Euclidean edge lengths) to their actual Euclidean distance is at most $t$. An imprecise point set is modeled by a set $R$ of regions in $\mathbb{R}^d$. If one chooses a point in each region of $R$, then the resulting point set is called a precise instance of~$R$. An imprecise $t$-spanner for an imprecise point set $R$ is a graph $G=(R,E)$ such that for each precise instance $S$ of $R$, graph $G_S=(S,E_S)$, where $E_S$ is the set of edges corresponding to $E$, is a $t$-spanner. In this paper, we show that, given a real number $t>1$, there is an imprecise point set $R$ of $n$ straight-line segments in the plane such that any imprecise $t$-spanner for $R$ has $\Omega(n^2)$ edges. Then, we propose an algorithm that computes a Well-Separated Pair Decomposition (WSPD) of size ${\cal O}(n)$ for a set of $n$ pairwise disjoint $d$-dimensional balls with arbitrary sizes. Given a real number $t>1$ and given a set of $n$ pairwise disjoint $d$-balls with arbitrary sizes, we use this WSPD to compute in ${\cal O}(n\log n+n/(t-1)^d)$ time an imprecise $t$-spanner with ${\cal O}(n/(t-1)^d)$ edges for balls.
Longitudinal observation of parechovirus in stool samples from Norwegian infants

Parechoviruses are assumed to be common infectious agents, but their epidemiologic and pathogenic properties are not well known. The aim of the present study was to assess the prevalence and molecular epidemiology of Parechovirus in Norwegian infants, as well as to investigate whether the presence of virus correlated with symptoms of infection. A group of 102 infants was longitudinally followed: 51 infants with a high genetic risk for type 1 diabetes (aged 3–35 months), and 51 children without this genotype (aged 3–12). Stool samples were obtained each month, and symptoms of infection were recorded regularly on questionnaires. Human parechovirus was detected in 11.3% of 1,941 samples examined by real‐time RT‐PCR. There was a distinct seasonality, peaking from September to December. By 12 months of age, 43% of the infants had had at least one infection, while 86% of the infants had encountered the virus by the end of the second year. Based on the VP1 sequence, human parechovirus 1 was the most prevalent type (76%), followed by human parechovirus 3 (13%), human parechovirus 6 (9%), an unclassified human parechovirus (1%), and human parechovirus 2 (1%). Ljungan virus, a murine parechovirus, was examined with a separate real‐time RT‐PCR, but no virus was detected. There was no significant association between infections and the following symptoms: coughing, sneezing, fever, diarrhea or vomiting. In conclusion, human parechovirus infects frequently infants at an early age without causing disease. J. Med. Virol. 80:1835–1842, 2008. © 2008 Wiley‐Liss, Inc.
Patch Esophagoplasty with Free Forearm Flap for Focal Stricture of the Pharyngoesophageal Junction and the Cervical Esophagus

Focal stricture of the cervical esophagus can be caused by corrosive injury or irradiation or following esophageal reconstruction. For severe stricture that cannot be relieved by bougie dilatation, surgical correction should be done. Among the operations performed, the myocutaneous flap is considered the first choice. Patch esophagoplasty with a free flap is indicated in the following situations: (1) when the patient is a young woman, (2) when the patient is obese, and (3) following irradiation that renders myocutaneous flaps unreliable. For correction of focal stricture of the cervical esophagus, six patients underwent esophagoplasty with a patch of free forearm flap. In comparison with other methods, this approach is associated with less morbidity and a better aesthetic result. The patients started oral intake at 1 month. Only one patient had minor leakage, and this healed after conservative treatment. The skin patch inserted in the esophageal wall caused no problem in motility, and the patients could eat smoothly after surgery.
Identification of Sensory Processing and Integration Symptom Clusters: A Preliminary Study

Rationale This study explored subtypes of sensory processing disorder (SPD) by examining the clinical presentations of cluster groups that emerged from scores of children with SPD on the Sensory Processing 3-Dimension (SP-3D) Inventory. Method A nonexperimental design was used involving data extraction from the records of 252 children with SPD. Exploratory cluster analyses were conducted with scores from the SP-3D Inventory which measures sensory overresponsivity (SOR), sensory underresponsivity (SUR), sensory craving (SC), postural disorder, dyspraxia, and sensory discrimination. Scores related to adaptive behavior, social-emotional functioning, and attention among children with different sensory modulation patterns were then examined and compared. Results Three distinct cluster groups emerged from the data: High SOR only, High SUR with SOR, and High SC with SOR. All groups showed low performance within multiple domains of adaptive behavior. Atypical behaviors associated with social-emotional functioning and attention varied among the groups. Implications The SP-3D Inventory shows promise as a tool for assisting in identifying patterns of sensory dysfunction and for guiding intervention. Better characterization can guide intervention precision and facilitate homogenous samples for research.
Decreased GABAA and GABAB receptor functional activity in cannabinoid CB1 receptor knockout mice

The interaction between brain GABAergic and endocannabinoid systems was evaluated by examining the quantitative and functional status of GABAergic receptors in cannabinoid CB1 receptor knockout (CB1 -/-) mice. To this aim, GABAA ([3H]-Muscimol binding assay), GABAB (baclofen-stimulated [35S]-GTPγS binding assay), GABAAα1, GABAAα2 and GABAAγ2 receptors gene expression (real-time reverse transcriptase polymerase chain reaction [PCR]) were carried out in CB1 -/- and wild-type mice (CB1 +/+). [3H]-Muscimol binding assays revealed significant reduction in the density of GABAA receptors in CA2 (30%) and DG (28%) of the hippocampus, thalamus (40%), cingulate (28%) and motor cortex (35%) of CB1 -/- mice. Functional activity of metabotropic GABAB receptors was measured by evaluating the ability of GABAB agonist baclofen to stimulate [35S]-GTPγS binding. The results showed significant reduced [35S]-GTPγS binding in CA1 (61%), CA3 (51%) and DG (60%) of CB1 -/- mice compared with CB1 +/+ mice. Real-time reverse transcriptase PCR was carried out for evaluating gene expression of α1, α2 and γ2 subunits of GABAA receptor in the amygdala. The results showed significant reduced GABAAα1 (50%) and GABAAα2 (40%) receptor subunits gene expression in the amygdala of CB1 -/- mice. No difference was observed in GABAAγ2 receptor subunit gene expression. This study provides strong evidence of the involvement of CB1 receptors in the control of GABAergic responses mediated by GABAA and GABAB receptors, and suggests a possible role of the endocannabinoid system in the regulation of anxiety-related disorders.
Hornwort pyrenoids, carbon-concentrating structures, evolved and were lost at least five times during the last 100 million years

Ribulose-1,5-Biphosphate-carboxylase-oxygenase (RuBisCO) has a crucial role in carbon fixation but a slow catalytic rate, a problem overcome in some plant lineages by physiological and anatomical traits that elevate carbon concentrations around the enzyme. Such carbon-concentrating mechanisms are hypothesized to have evolved during periods of low atmospheric CO2. Hornworts, the sister to vascular plants, have a carbon-concentrating mechanism that relies on pyrenoids, proteinaceous bodies mostly consisting of RuBisCO. We generated a phylogeny based on mitochondrial and plastid sequences for 36% of the approximately 200 hornwort species to infer the history of gains and losses of pyrenoids in this clade; we also used fossils and multiple dating approaches to generate a chronogram for the hornworts. The results imply five to six origins and an equal number of subsequent losses of pyrenoids in hornworts, with the oldest pyrenoid gained ca. 100 Mya, and most others at <35 Mya. The nonsynchronous appearance of pyrenoid-containing clades, the successful diversification of pyrenoid-lacking clades during periods with low [CO2], and the maintenance of pyrenoids during episodes of high [CO2] all argue against the previously proposed relationship between pyrenoid origin and low [CO2]. The selective advantages, and costs, of hornwort pyrenoids thus must relate to additional factors besides atmospheric CO2.
An automatic saccadic eye movement detection in an optokinetic nystagmus signal

Abstract A saccade is one of the characteristic types of eye movements. The accurate detection and location of saccades in the signal representing the movement activity of the eyes are essential in medical applications. The main purpose of this paper is to present a new, robust approach to the detection of saccadic eye movements. The procedure is based on a so-called detection function, which is the result of the electronystagmographic (ENG) myriad signal filtering, nonlinear operation, and fuzzy median clustering. Smooth peaks of the detection function waveform correspond to the location of saccades in the ENG signal. The median fuzzy clustering-based method allows for calculating the amplitude threshold of the detection function, which improves the accurate saccade recognition. Both of these robust methods provide a two-step protection against outliers. The proposed algorithm was tested using artificial as well as real optokinetic nystagmus signals under different noise conditions. The results show the usefulness of the procedure when the precise detection and location of saccades are necessary.
The relationship between maximal oxygen uptake and repeated sprint performance indices in field hockey and soccer players.

BACKGROUND The purpose of this study was to examine the relationship between maximal oxygen uptake and repeated sprint performance in field hockey and soccer players. METHODS EXPERIMENTAL DESIGN a descriptive study on the aerobic-anaerobic performance of intermittent team game players. SETTING the study was conducted at the Sports Medicine and Research Centre. PARTICIPANTS forty male national team game players (22.6+/-4.2 years; 1.73+/-0.07 m and 63.7+/-6.2 kg) were involved in the study. MEASURES all subjects completed a treadmill run test to exhaustion to determine maximal oxygen uptake and 8x40 m sprints either on the field or running track to determine repeated sprint ability performance. RESULTS Body mass-normalised maximal oxygen uptake of 58.0+/-4.9 ml x kg(-1) x min(-1) of the group is comparable to values reported in the literature for team game players. No significant correlations were established between the fastest 40 m sprint time and maximal oxygen uptake (r=-0.21 and -0.08, p>0.05). Moderate correlations were established between maximal oxygen uptake and total time for the eight sprints (r=-0.346 and -0.323; p<0.05). CONCLUSIONS Maximal oxygen uptake was not correlated with the fastest 40 m sprint time but was moderately correlated with total sprint time. Since the shared variance between maximal oxygen uptake and total sprint time was only 12%, improving aerobic fitness further will only be expected to contribute marginally to improving repeated sprint performance of the team game players. It remains possible that a high level of aerobic fitness enhances other aspects of match play in games like soccer and hockey.
Joint Transceiver Designs for Full-Duplex $K$ -Pair MIMO Interference Channel With SWIPT

In this paper, we propose joint transceiver design algorithms for the full-duplex $K$ -pair multiple-input multiple-output interference channel with simultaneous wireless information and power transfer. To mitigate and exploit the complex interference, we consider two important utility optimization problems, i.e., the sum power minimization problem and the sum-rate maximization problem. In the first problem, our aim is to minimize the total transmission power under both transmission rate and energy harvesting (EH) constraints. An iterative algorithm based on alternating optimization (AO) and with guaranteed monotonic convergence is proposed to successively optimize the transceiver coefficients. The algorithm consists of three main steps, where the concave–convex procedure (CCCP), the minimum mean-square error (MMSE) criterion, and the semidefinite relaxation technique are, respectively, employed to compute the vectors of power splitting ratios, the receiving matrices, and the transmitting beamforming vectors. Two simplified algorithms based on fixed beamformers, namely, the maximum ratio transmission and the maximum signal-to-interference-leakage beamformers are also proposed. In the second problem, our aim is to maximize the sum-rate under additional power and EH constraints. Due to the highly non-convex nature of this problem, we first reformulate it into an equivalent-weighted MMSE problem by introducing suitable weight factors, such that the global optima of the two problems are identical. Then, by utilizing the concept of AO and CCCP, we show that the equivalent problem can be efficiently solved. Again, with the aid of the fixed beamformers, two simplified algorithms are provided to reduce the computational complexity. Simulation results are presented to validate the effectiveness of the proposed algorithms.
Risk Factors for the Development of Obstetric Anal Sphincter Injuries in Modern Obstetric Practice.

OBJECTIVE To characterize the rate of obstetric anal sphincter injuries and identify key risk factors of obstetric anal sphincter injuries, including duration of the second stage of labor. METHODS This retrospective cohort study included all singleton, term, cephalic vaginal deliveries within Kaiser Permanente Northern California between January 2013 and December 2014 (N=22,741). Incidence of obstetric anal sphincter injuries, defined as third- or fourth-degree perineal lacerations, was the primary outcome. Multiple logistic regression models were conducted to identify obstetric anal sphincter injury risk factors and high-risk subpopulations. RESULTS The overall incidence rate of obstetric anal sphincter injuries was 4.9% (3.6% of women who delivered spontaneously vs 24.0% of women who had a vacuum-assisted vaginal delivery, P<.001, CI 18.1-22.6%). In bivariate and multivariate analyses, obstetric anal sphincter injury incidence was higher among women with second stage of labor longer than 2 hours, Asian race, nulliparity, vaginal birth after cesarean delivery, episiotomy, and vacuum delivery. Women with a vacuum-assisted vaginal delivery had four times the odds of obstetric anal sphincter injury (adjusted odds ratio [OR] 4.23, 95% CI 3.59-4.98) and those whose second stage of labor lasted at least 180 minutes vs less than 60 minutes had three times the odds of incurring obstetric anal sphincter injury (adjusted OR 3.20, 95% CI 2.62-3.89). CONCLUSION Vacuum-assisted vaginal delivery conferred the highest odds of obstetric anal sphincter injury followed by prolonged duration of the second stage of labor, particularly among certain subpopulations. Understanding these risk factors and their complex interactions can inform antepartum and intrapartum decision-making with the goal of reducing obstetric anal sphincter injury incidence.
Rearrangeable and exchangeable optical module with system-on-chip for wearable functional near-infrared spectroscopy system

Abstract. We developed a system-on-chip (SoC)-incorporated light-emitting diode (LED) and avalanche photodiode (APD) modules to improve the usability and flexibility of a fiberless wearable functional near-infrared spectroscopy (fNIRS) system. The SoC has a microprocessing unit and programmable circuits. The time division method and the lock-in method were used for separately detecting signals from different positions and signals of different wavelengths, respectively. Each module autonomously works for this time-divided-lock-in measurement with a high sensitivity for haired regions. By supplying +3.3 V of power and base and data clocks, the LED module emits both 730- and 855-nm wavelengths of light, amplitudes of which are modulated in each lock-in frequency generated from the base clock, and the APD module provides the lock-in detected signals synchronizing with the data clock. The SoC provided many functions, including automatic-power-control of the LED, automatic judgment of detected power level, and automatic-gain-control of the programmable gain amplifier. The number and the arrangement of modules can be adaptively changed by connecting this exchangeable modules in a daisy chain and setting the parameters dependent on the probing position. Therefore, users can configure a variety of arrangements (single- or multidistance combinations) of them with this module-based system.
Mechanical elasticity of vapour–liquid–solid grown GaN nanowires

Mechanical elasticity of hexagonal wurtzite GaN nanowires with hexagonal cross sections grown through a vapour–liquid–solid (VLS) method was investigated using a three-point bending method with a digital-pulsed force mode (DPFM) atomic force microscope (AFM). In a diameter range of 57–135 nm, bending deflection and effective stiffness, or spring constant, profiles were recorded over the entire length of end-supported GaN nanowires and compared to the classic elastic beam models. Profiles reveal that the bending behaviour of the smallest nanowire (57.0 nm in diameter) is as a fixed beam, while larger nanowires (89.3–135.0 nm in diameter) all show simple-beam boundary conditions. Diameter dependence on the stiffness and elastic modulus are observed for these GaN nanowires. The GaN nanowire of 57.0 nm diameter displays the lowest stiffness (0.98 N m−1) and the highest elastic modulus (400 ± 15 GPa). But with increasing diameter, elastic modulus decreases, while stiffness increases. Elastic moduli for most tested nanowires range from 218 to 317 GPa, which approaches or meets the literature values for bulk single crystal and GaN nanowires with triangular cross sections from other investigators. The present results together with further tests on plastic and fracture processes will provide fundamental information for the development of GaN nanowire devices.