Miracle-dz/UniFAR-FTUs huggingface dataset:
PML nuclear bodies: regulation, function and therapeutic perspectives

PML nuclear bodies (NBs) were first described by electron microscopy and rediscovered through their treatment‐reversible disruption in a rare leukaemia. They recruit multiple partner proteins and now emerge as interferon‐ and oxidative stress‐responsive sumoylation factories. NBs mediate interferon‐induced viral restriction, enhance proteolysis, finely tune metabolism and enforce stress‐induced senescence. Apart from being markers of cellular stress, PML NBs could be harnessed pharmacologically in a number of conditions, including cancer, viral infection or neurodegenerative diseases. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Prediction of IMD behaviour in LDMOS transistor amplifiers using a physics-based large signal compact model

In this paper, intermodulation distortion (IMD) analysis is carried out for silicon-on-insulator lateral double-diffused metal-oxide-semiconductor using a physics-based large signal model implemented in Verilog-A. The model is found to predict the static and dynamic characteristics accurately along with the higher order derivatives of transconductance and capacitances in all regions of operations. A power amplifier (PA) is designed both within the TCAD mixed-mode simulation framework and circuit simulator using the Verilog-A compact model. One-tone and two-tone analysis are carried out for the PAs designed in TCAD and circuit simulators. It is found that the Verilog-A compact model can accurately predict the existence of double IMD sweetspots for class AB operation when compared with the TCAD results. Also for the output power, power gain and power added efficiency, the model predictions are in agreement with those of the TCAD simulation data.
Securing Frontline Employee Support After an Ethical Scandal

Although ethical scandals are a common phenomenon in the service industry, there is little research on the service-specific aspects of crisis management. In this research, we argue that frontline employees are of crucial importance after a scandal and examine how firms can secure the support of frontline employees following different kinds of scandals. Specifically, we demonstrate that corrective responses that address the internal causes of a scandal and ceremonial responses that guide attention to positive aspects unrelated to the scandal moderate the impact of different scandals on frontline employee support. Three experiments showed that frontline employee support was greater after scandals that involved a great rather than a small number of wrongdoers and after scandals that had been caused by high-ranking managers rather than low-ranking employees when a corrective response was implemented. In contrast, support was greater following scandals that had been committed by a few low-ranking employees rather than high-ranking managers when a ceremonial response was employed. These results have important implications by illustrating how companies can effectively restore frontline employee support following a scandal.
Twitter as a communication tool for executives뀀Ƞ A study on HP Norway뀀Ƞ

5 1. Introduction 13 1.1 Theme and Background 13 1.2 Motivation for this research project 15 1.2. 1 My role as a researcher 16 1.3 Research question 18 1.3. 1 Explanation of terms 18 1.4 Thesis structure 19
Hardware Performance of ELmD and ELmD(6,6)

—ELmD (Encrypt-Linear mix-Decrypt) is a block-cipher based efficient authenticated encryption scheme, which is nonce misuse resistant, fully pipeline implementable. ELmD is a candidate for CAESAR competition and it has been selected for the second round. In this document, we first consider two versions of ELmDv2.0-(i) ELmD: full 10-round AES encryption-decryption, no intermediate tag, fixed tag size and (ii) ELmD(6,6): 6-round AES encryption-decryption, no intermediate tag, fixed tag size. We provide the full specification for both the version and present hardware implementation of the combined encryption-decryption for both these versions. We discuss and compare the hardware performance of these versions with other popular AE schemes like COPA and OCB.
An Operational Model for Microchannel Plate Devices

The behavior of optical detectors using microchannel plates (MCPs) as electron multipliers is described in terms of the physical parameters of the MCP (channel resistance, channel capacitance, channel wall secondary emission ratio, etc.). Three operating modes are included: (1) DC operation at low light levels, (2) pulse detection operation at high peak currents, and (3) single electron counting with cascaded V-plate and Z-plate MCPs.
Circadian (24-hour) pattern of intraocular pressure and visual field damage in eyes with normal-tension glaucoma.

PURPOSE To characterize the circadian (24-hour) pattern of habitual-position intraocular pressure (IOP) and its association with visual field (VF) damage in eyes with normal-tension glaucoma (NTG). METHODS A total of 177 eyes with NTG were examined over a 3-year period. IOP was recorded at 8 AM, 10 AM, 12 PM, 2 PM, 4 PM, 6 PM, 8 PM, 10 PM, 12 AM, 3 AM, and 6 AM by a single, well-trained ophthalmology resident using a hand-held tonometer. The circadian pattern and peak hours of habitual-position IOP and seated IOP were analyzed in all patients. Subgroup analysis was also performed, with groups defined by the time of maximum habitual-position IOP. The relationship between 24-hour habitual-position IOP parameters and VF indices was evaluated. RESULTS There were 72 men and 105 women, all of whom were Koreans. Analysis of the entire population indicated a nocturnal peak (acrophase) for habitual-position IOP. Subgroup analysis indicated that 28 (15.8%) patients had diurnal acrophase, 91 (51.4%) patients had nocturnal acrophase, and 58 (32.8%) patients had no evident acrophase. There were no correlations between various 24-hour habitual-position IOP parameters and VF indices. CONCLUSIONS In the 177 NTG patients, there was a significant nighttime elevation of habitual-position IOP, and nocturnal seated IOP was significantly less than nocturnal habitual-position IOP. Subgroup analysis indicated three distinct daily patterns of peak IOP in the patients. There was no relationship between nocturnal elevation of habitual IOP and the magnitude of VF damage.
Expression of Annexin A5 Is Associated With Higher Tumor Stage and Poor Prognosis in Colorectal Adenocarcinomas

Goals To gain an insight into the putative role of annexin A5 (ANXA5) in the tumor stage and its clinical outcome. Background ANXA5 is a calcium-binding protein, which has been implicated in the carcinogenesis of several carcinomas. However, the role of ANXA5 in colorectal cancer (CRC) is unclear. Study We investigated the expression of ANXA5 in colorectal adenocarcinoma. This study included 207 consecutive patients with sporadic CRC. Paired colorectal tissue samples and corresponding nonmalignant tissues were obtained by surgical resection. ANXA5 mRNA and protein expression in each tissue were assessed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemical staining. Data were statistically correlated with pathologic parameters and clinical outcome. Results Real-time reverse transcriptase polymerase chain reaction showed that there is an up-regulation in the mRNA level of ANXA5 in tumors (P<0.001). Immunohistochemical study revealed that high ANXA5 expression was present in 40.58% (84 of 207) of tumors. Univariate analysis showed increased ANXA5 expression correlated with pT stage (P=0.008), liver metastasis (P=0.024), pathologic tumor-node–metastasis stage (P=0.015), Dukes' stage (P=0.017), recurrence (P=0.024), cancer-related death (P=0.028), recurrence-free probability (P=0.003), and overall survival (P=0.005). Multivariate analysis showed that ANXA5 expression and liver metastasis significantly correlated with recurrence-free probability (P=0.039 and P=0.048, respectively) and overall survival (P=0.012 and P=0.021, respectively) independent of pT stage and pN stage. Conclusions From these findings ANXA5 expression seems to be related to the tumor stage and clinical outcome of CRC. Thus ANXA5 could serve as a prognostic marker for tumor progression.
Modeling and Simulation for Homeland Security.

Critical infrastructure and its interdependencies play a vital role in our daily functions. Our economies, government, and way of life depend on the sound function of these integrated systems. Analysis of these systems, however, has historically been limited: system owners and operators have limited information outside their domain space (and that legal impediments often limit their ability to better understand the broader system), and very few entities have the desire to better understand these systems as a whole, let alone their interconnections. The National Infrastructure Simulation and Analysis Center (NISAC) is one such entity. NISAC, a program managed by the U.S. Department of Homeland Security (DHS) and comprised of a core partnership of Sandia National Laboratories (SNL) and Los Alamos National Laboratory (LANL), draws on years of modeling experience of various types, focused on infrastructure, population, and the economy, to examine questions pertinent to DHS regarding the function of economy and critical infrastructure of the United States (see Figure 1). This paper is designed to provide a background on the NISAC program as a whole, including a description of the legislative and funding history behind the program. Additionally, a review of the program’s early days, and the modeling and simulation tools developed for other customers that were repurposes and enhanced to meet homeland security mission space is performed. The beginnings of rapid response analysis are discussed; these grew in significance as the result of events such as Hurricane Katrina, and brought about changes both to processes and tool development. These events also led to a change in NISAC’s analytic thought process, from an exclusively reactive one to an increasingly proactive one; this change in thought has led to the development of capabilities to address as-yet unseen events that provide US DHS both with benchmark analyses that can be used in the events of a similar event, as well as capabilities to address similar real-world problems. A review of the path ahead for NISAC highlights both the challenges and potential for the program as it moves into its second decade. Figure 1. NISAC uses a range of modeling capabilities across the set of critical infrastructure sectors to address questions of consequence to infrastructure, populations, and the economy for hurricanes, earthquakes, pandemics, and other changes to the normal function of systems.
The influence of organizational subcultures in health organizations

This study investigates the mediating role of organizational subculture and its antecedents of organizational commitment namely leadership, culture and job satisfaction. Structural equation analysis is used to examine our model in which organizational subculture mediated the influence of leadership style and organizational culture on commitment, and in which job satisfaction is an antecedent of commitment. The results of this study highlight the important role of local leadership and subculture in determining employees’ job satisfaction and commitment. The findings in this study could also provide managers with a new lens to examine organizational culture via three perspectives: bureaucratic, supportive and innovative. Furthermore, the results could renew interests in developing other organizational subculture models that could determine the relationship between organizational subculture and commitment
An Empirical Study of HR Factors as Determinants of Talent Management

An organization's ability to learn and translate that learning into action rapidly is the ultimate connpetitive business advantage. One key corporate responsibility is to enable people to use and develop their individual talents. Organizations must ensure that people can fulfill their needs and find their potential in their work experience. Jobs should be designed to match people's talents. Contributions to the quality of the workplace are highly valued. Organizations should provide a complete range of HR services including HR consulting, HR technology and HR outsourcing. Some organizations, like Infosys', are already using Human Capital Management (HCM) practice to help clients differentiate and achieve operational excellence. The present work represents how the organizations can bring right kind of talent at the work place and how that talent can be retained. Through literature survey eleven factors contributing to talent management have been identified which are: creativity&resourcefulness, problem solving&decision making, communication, team building, entrepreneurship, leadership, general managerial skills, learning ability, performance measurement, career development, inspirational capabilities. Various statistical tests like inter item analysis, correlation analysis, multiple regression are performed to examine the relationship between different factors and talent management on a sample of 100 trainees of ACC who were attending their training program at Indian Institute of Technology, Roorkee. The results reveal that among all other factors inspirational capability is the prime factor contributing to talent management. On the other hand organization should put in more effort to creativity and innovativeness as these are the essential ingredients in the current global competitive environment for any organization to survive. Based on this study a model for talent management is suggested.
Estimate Of Reference Effective Dose And Renal Dose During Abdominal CT Scan For Dose Optimization Procedures In Ghana

The study is to estimate renal and effective dose during abdominal MDCT scan, using image data for dose optimization for purposes of radiation protection in Ghana. In addition dose influencing parameters including: CTDIVOL, DLP and MSAD were recorded and compared with ICRP/ICRU, AAPM, EU and IAEA dose optimization recommendations. All the measurements were done during abdominal MDCT examination. The measured parameters were part of image data on the MeVisLab (DICOM) application software platform. The total photon fluence (mAs per area) and the photon energy fluence (kVp per area) on the abdominal and renal surface was also determined. Renal and effective dose were estimated using ICRP publication 103 recommendations. The results of the measured parameters based on the average renal surface area of 29.52cm 2 and 30.67cm 2 for the right and left kidney respectively, shows that: The mean dose parameters were; 6.33mGy, 7.78mGy, 936.25mGy cm, 5.76mGy, 10.99mSv and 14.09mSv for CTDIV, CTDIW, DLP, MSAD, RD and E respectively. The average values were lower than the general recommended average critical values, but this seems misleading, based on the fact that 37% of the individual dose and exposure parameters exceeded the recommended critical values. A tradeoff between patient radiation dose and image quality in abdominal CT has been established. Where at a mean SNR of 6.6 decibels an adequate images were produce to answer all the clinical questions, with an average effective dose of 14.09mSv and renal dose of 10.99mSv. Radiation dose during x-ray CT imaging is an important patient safety concern. Reducing radiation dose result in a reduction of the risk to patient; however, reducing dose also reduces the signal strength and thereby reduces the signal to noise ratio in the resulting CT image, hence, the image quality is affected. It is recommended that the established reference values be use as clinical advisory mechanism to protect patience and clinicians. It is also recommended that the studies should be carry out periodical to estimates the abdominal effective dose in all the centers.
Remark on "Some simple chaotic flows"

Sprott [Phys. Rev. E 50, 647 (1994)] developed a computerized search method and applied it to generate [ital millions] of sets of coupled chaotic ordinary differential equations. Each of the sets contained three coupled quadratic equations. Of these, the simplest, Sprott's case A, is the set of equations that Posch, Hoover, and Vesely [Phys. Rev. A 33, 4253 (1986)] used to describe a single one-dimensional Nose-Hoover oscillator. In this sense, the Nose-Hoover oscillator system is the simplest mechanical system exhibiting chaos.
Design of Hybrid-Electric Small Air Transports

The potential benefits of hybrid-electric or full-electric propulsion have led to the proliferation of many concepts over the past decade. The lack of conceptual design methods capable of grasping the effects of the new propulsive technologies is often due to the absence of industrial data supporting the research. In the present work, two objectives are pursued. On the one hand, the introduction of semi-empirical methods for weight estimation based on the data provided by the industrial partners of the ELICA CS2 project. On the other hand, the establishment of generative engineering as a conceptual design tool for propulsive system architecting and fault tolerance analysis. The applications of the proposed conceptual design methods deal with two different years of entrance in service.
Thermal Analysis of High Speed PM Generator used for distributed generation system

A 100kW level High-Speed Permanent Magnetic Generator (HSPMG) used for distributed generation systems is electro-thermal analyzed with coupling in this paper. Its electromagnetic performances is analyzed by using time step FEA, from which the electromagnetic performance and loss distributions in machine under rated operating are determined. Based on the determination of associated heat transfer conditions, the whole region two-dimensional thermal field is calculated. Then, thermal performance of HSPMG with stator oil separators made of nano AIN and ceramic material are studied, and also the cooling structure without oil separator is analyzed. Meanwhile, thermal affection of the insertion of ceramic gradient thermal barrier coatings between rotor magnets and sleeve is researched, and temperature distributions of machines with different thickness thermal barrier coatings are studied. Some conclusions about influences of material and structure on HSPMG thermal performance are obtained, which may provide useful reference for the design and research of HSPMG.
Geometric Quality Analysis of AVHRR Orthoimages

The geometric accuracy of 2008 AVHRR orthoimages from Metop-A, NOAA-17 and NOAA-18 satellites over Switzerland have been investigated here. The methods employed in the study are fully automated, with an accuracy of 0.1–0.2 pixels, however, blunders do occur and this requests a careful blunder detection approach. The investigations include analysis of relative, absolute and band-to-band registration (BBR) accuracy. Regarding relative accuracy, thousands of points are matched between Metop-A, NOAA-17 and NOAA-18 images of the same day. The accuracy is quite high with mean shifts between 0.2 and 0.4 pixels. Systematic stripes have been observed when NOAA-18 images are involved in matching. In spite of many efforts to find the source of this error, no explanation could be found. In addition, large shifts up to 2.9 pixels on some days between September and December 2008 were observed. Regarding absolute accuracy, digitized lakes as reference polygons have been used and a subpixel lake matching method has been applied. The mean shifts generally fulfilled EUMETSAT and GCOS specifications, although some partial results exceed them, especially for Metop-A. Regarding BBR accuracy, six multispectral bands have been compared, also with point matching. The EUMETSAT specification is 0.1 km, however, this specification refers to original images, not orthoimages. Taking also into account the matching errors of 0.1 km, the EUMETSAT specifications are in principle fulfilled in all cases except matching of Metop-A and NOAA-17 Band-2 images with Bands 4 and 5. The overall work showed that although, in general, accuracies are high and fulfill specifications, errors exceeding the specifications can occur and vary depending on the satellite used, time and location. Such errors influence subsequent geometric or thematic processing; thus, an automated and permanent quality control of such images should be executed.
The Effect of Work Motivation and Entrepreneurship Orientation on Business Performance through Entrepreneurial Commitments of Coffee Shops in Makassar

This study aimed to explore the effect of work motivation and entrepreneurship orientation on businesses performance of small and medium enterprises (SMEs), particularly for the coffee shop in Makassar. This study was included in the category of explanatory research that aimed to explore the facts through the collection of secondary and primary data with questionnaires and interview techniques related to entrepreneurial orientation, achievement motivation and its impact on business performance in the SMEs in Makassar. This study also used path analysis approach as an engineering approach in statistics to examine direct and indirect relationships between exogenous and endogenous variables. Some important aspects need to be explored explicitly related to the method used. The important issues included the nature of the study, the type of investigation, the level of intervention research, the situation of the study, the unit of analysis, and the time horizon. The results of this study showed that the entrepreneurial orientation and motivation either partially or simultaneously to the coffee shop business in Makassar had a positive effect. In this case, entrepreneurial orientation had a positive and signifi cant effect on business performance. Meanwhile, the orientation of work motivation, directly and indirectly, had a positive and signifi cant effect on the business performance of coffee shop business in Makassar. In other cases, the commitments had important roles in giving positive effect to business performance related to the coffee shop business in Makassar.
Late-Onset Sensorineural Hearing Loss Due to Asymptomatic Congenital Cytomegalovirus Infection Retrospectively Diagnosed by Polymerase Chain Reaction Using Preserved Umbilical Cord

Sensorineural hearing loss is the most common neurological sequel of congenital cytomegalovirus (CMV) infection. Congenital CMV infection is considered to be res pon sible for 15% to 25% of hearing loss among children in the United States. Hearing loss in children with congenital CMV infection often presents at birth, but it can develop after months or even years. Although there have been reports on late-onset hearing loss by 6 years of age, the onset of hearing loss beyond 6 years has rarely been reported. Virologic proof is not always easy in patients with asymptomatic congenital CMV infection beyond infancy. However, there have been several reports on retrospective diagnosis of congenital CMV infection by polymerase chain reaction (PCR) for umbilical cord or blood stored on a Guthrie card. We report a boy with onset of hearing loss at 9 years of age, in whom congenital CMV infection was retrospectively proven by PCR with the use of preserved umbilical cord.
Role of Protein and Amino Acids in the Pathophysiology and Treatment of Sarcopenia

Sarcopenia, the loss of skeletal muscle mass and function with aging, is a multifactorial condition that slowly develops over decades and becomes a significant contributor to disability in the older population. Malnutrition and alterations in the muscle anabolic response to nutritional stimuli have been identified as potentially preventable factors that may significantly contribute to sarcopenia. Thus, nutritional interventions may be useful for the prevention and treatment of sarcopenia.