Miracle-dz/UniFAR-FTUs huggingface dataset:
Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum

We have introduced long precursor peptides directly into the endoplasmic reticulum (ER) of a mutant cell line (T2-Db) that lacks the ability to transport peptides from the cytosol to the ER in a transporter associated with antigen processing (TAP) dependent way. This was done by expressing various influenza A-derived peptides containing the naturally processed epitope ASNENMDAM (366-374) preceded by the influenza hemagglutinin ER translocation sequence. Peptides derived from these minigenes that became associated with Db were isolated and identified by combined reversed phase liquid chromatography and detection by cytotoxic T lymphocytes. Our results establish that NH2-terminal extensions of at least 40 residues can be trimmed from peptides entering the ER, but that proteolysis of larger proteins may be limited.
The Study of Fingerprint Characteristics of Dayi Pu-Erh Tea Using a Fully Automatic HS-SPME/GC–MS and Combined Chemometrics Method

The quality of tea is presently evaluated by the sensory assessment of professional tea tasters, however, this approach is both inconsistent and inaccurate. A more standardized and efficient method is urgently needed to objectively evaluate tea quality. In this study, the chemical fingerprint of 7 different Dayi Pu-erh tea brands and 3 different Ya'an tea brands on the market were analyzed using fully automatic headspace solid-phase microextraction (HS-SPME) combined with gas chromatography-mass spectrometry (GC–MS). A total of 78 volatiles were separated, among 75 volatiles were identified by GC–MS in seven Dayi Pu-erh teas, and the major chemical components included methoxyphenolic compounds, hydrocarbons, and alcohol compounds, such as 1,2,3-trimethoxybenzene, 1,2,4-trimethoxybenzene, 2,6,10,14-tetramethyl-pentadecane, linalool and its oxides, α-terpineol, and phytol. The overlapping ratio of peaks (ORP) of the chromatogram in the seven Dayi Pu-erh tea samples was greater than 89.55%, whereas the ORP of Ya'an tea samples was less than 79.10%. The similarity and differences of the Dayi Pu-erh tea samples were also characterized using correlation coefficient similarity and principal component analysis (PCA). The results showed that the correlation coefficient of similarity of the seven Dayi Pu-erh tea samples was greater than 0.820 and was gathered in a specific area, which showed that samples from different brands were basically the same, despite have some slightly differences of chemical indexes was found. These results showed that the GC-MS fingerprint combined with the PCA approach can be used as an effective tool for the quality assessment and control of Pu-erh tea.
Draft Genome Sequence of the Hydrogen- and Ethanol-Producing Anaerobic Alkalithermophilic Bacterium Caloramator celer

ABSTRACT Caloramator celer strain JW/YL-NZ35 is a Gram-positive thermophilic, alkalitolerant, and strictly anaerobic bacterium capable of producing hydrogen and ethanol under extreme conditions. The draft genome sequence presented here will provide valuable information to further explore the physiology of this species and its potential for biofuel production.
Circumcision in paediatric surgery using an ultrasound dissection scalpel.

In contrast to electrocautery, the ultrasound dissection scalpel allows tissue dissection and haemostasis to be performed without the danger of thermal tissue damage or burning caused by uncontrolled active current. In a clinical application study performed on 24 boys with an average age of six years, we examined whether the use of this instrument is also practical in a routine operation such as circumcision. It was possible to perform all operations with the ultrasound dissection scalpel (Ultracision, manufactured by Ethicon) by the classic technique without the additional use of electrocautery for haemostasis. Although dissecting speed is slower than with conventional instruments, the fact that simultaneous haemostasis is possible meant that operations could be carried out quickly and with minimal bleeding. There were no perioperative complications such as haemorrhaging or burning. All children were examined postoperatively over an average of 3 weeks (range 1-8 weeks). Wound healing was completely without complications for 22 patients (92%). One patient (4%) suffered a candidal infection in the first postoperative week. One further patient (4%), who was already suffering preoperatively from an extended chronic inflammation of the prepuce, developed pronounced swelling postoperatively. Heavy scarring occurred subsequently in both cases. Our results show that the advantages of the ultrasound dissection scalpel, e.g. gentle tissue dissection with simultaneous haemostasis, can also be used to advantage for a technically simple operation such as circumcision without having to fear the risks of electrocautery.
A deskilling and challenging journey: the lived experience of Indonesian nurse returnees

AIM To illuminate the lived experiences of Indonesian nurses who previously worked as caregivers in Japanese residential care facilities, by exploring the journey of becoming returnees. BACKGROUND The creation of bilateral agreements between Indonesia and Japan has facilitated the movement of Indonesian nurses to work as caregivers in Japan since 2008. While this decision raised concerns with regard to the degradation of nursing skills, little is known about this issue from the perspective of nurse returnees and how the experience affects their life. METHOD A hermeneutic phenomenological method was employed for this study. A purposive sample of 15 Indonesian nurse returnees participated in this study. Semi-structured interviews were conducted in four of Indonesia's provinces between August and October 2015. Data were analysed thematically, supported by QSR NVIVO 10 software. FINDINGS Four key themes emerged from the data analysis: (i) returning home; (ii) going back to zero; (iii) walking through a difficult journey; and (iv) overcoming barriers. These findings described the lived experiences of nurse returnees when they got back to the country of origin. CONCLUSION Indonesian nurse returnees experienced deskilling and struggled to re-enter the nursing profession or to find other non-nursing jobs. The significant impact of this migration on individual nurses with regard to maximizing the benefits of return migration deserves further investigation. IMPLICATION FOR NURSING AND HEALTH POLICY The Indonesian government, jointly with other stakeholders, should develop a brain gain strategy to align returnees' expertise with the needs of the national labour market. The public-private partnership should be strengthened to utilize returnees in healthcare services.
Living donor liver transplantation: complications in donors and interventional management.

PURPOSE To evaluate the incidence of postoperative complications in liver donors and the efficacy of interventional management for treating these complications. MATERIALS AND METHODS The study included 386 consecutive donors: 219 donors underwent right lobectomy or segmentectomy and 167 donors underwent left lobectomy or segmentectomy. Postoperative status, laboratory data, and radiologic images were reviewed for postoperative complications. Interventional management consisted of percutaneous drainage, ultrasonographic (US)-guided aspiration, percutaneous transhepatic biliary drainage (PTBD) and balloon dilation, transcatheter arterial embolization, or portal vein stent placement. Technical success, clinical improvement, and complications were documented following intervention. RESULTS In 52 (13.5%) donors, 56 postoperative complications were encountered, including pleural effusion (n = 9), biliary leakage (n = 6), biliary obstruction (n = 5), intraperitoneal abscess (n = 5), active bleeding (n = 5), portal vein stenosis or kink (n = 3), biloma (n = 2), and other complications (n = 21). Complications occurred in 41 (18.9%) right lobe and 11 (7.0%) left lobe donors (P <.001). Twenty-seven (48%) complications were treated with interventional management (percutaneous drainage, n = 10; US-guided aspiration, n = 6; PTBD and balloon dilation, n = 4; transcatheter arterial embolization, n = 4; and stent placement, n = 3) and resolved completely. No procedure-related complications occurred. In one donor with venous oozing, arteriographic images did not show an active bleeding focus; thus, bleeding control with interventional management failed. The remaining 29 complications were treated using medical (n = 27) or surgical (n = 2) management. One donor with acute renal failure has thus far been treated with hemodialysis. CONCLUSION Although complications from liver donation are not uncommon, most are minor and, with medical or interventional management, have no long-term sequelae. Interventional management seems useful in the treatment of postoperative complications of liver donation.
A CMOS third order ΔΣ modulator with inverter-based integrators

This paper presents a CMOS third order ΔΣ modulator with inverter-based integrators for low power audio signal processing application. In order to minimize the power consumption of the proposed modulator, the inverters embedded into integrators and an analog adder operating in the subthreshold region were implemented on an 180nm CMOS technology with digital and analog power supply of 1.8V and 0.8V, respectively. The measurement results demonstrated ENOB of 13.1bit, DR of 86.1dB, total power dissipation of 92uW, and FOM(walden) of 260 fJ/step at sampling frequency of 2.56 MHz and input signal frequency of 2.5kHz.
Buzzing health: health education by buzz compared to print media

Marketeers and service providers increasingly turn to word of mouth (WOM) as a means to persuade and inform individuals regarding an organization, brand or product. Positive results have been reported within the commercial sector, but does WOM also work within the context of a health education campaign? To explore the potential of WOM in health education, effects of medium channel (WOM vs. print vs. control condition) and consumer involvement (low vs. high) on participant responses were investigated. Furthermore, additional in-depth interviews were conducted in which participants disclosed their experiences. The findings suggest that WOM communications, instigated by a relatively small number of highly involved participants, can inspire attitude change among those who are lowly involved with the subject at hand. Interview results, however, indicate that health professionals should be aware of the increased efforts required from participants that WOM entails.
Matrix theory, AdS/CFT and Higgs-Coulomb equivalence

We discuss the relation between the Matrix theory definitions of a class of decoupled theories and their AdS/CFT description in terms of the corresponding near-horizon geometry. The near horizon geometry, naively part of the Coulomb branch, is embedded in the Higgs branch via a natural change of variables. The principles of the map apply to all DLCQ descriptions in terms of hyper-K? hler quotients, such as the ADHM quantum mechanics for the D1-D5 system. We then focus the (2,0) field theory, and obtain an explicit mapping from all states in the N0 = 1 momentum sector of N4 M5-branes to states in (a DLCQ version of) AdS7 ? S4. We show that, even for a single D0-brane, the space-time coordinates become non-commuting variables, suggesting an inherent non-commutativity of space-time in the presence of field strengths even for theories with gravity.
An efficient rate adaptation scheme for multihop wireless networks using Kalman Filter

Mobile devices in the IEEE 802.11 based multihop ad hoc networks support the transmission of data frames at various predefined transmission rates. To achieve high throughput performance, these multiple rates should be exploited and used in an adaptive manner depending on the channel condition. In this paper, we propose a data rate adaptation scheme with the use of Kalman filter to determine the channel conditions (forthcoming interference). Upon receiving the RTS (request to send) packet, the receiver predicts the future interference and accordingly selects the appropriate transmission rate. Then, the receiver encapsulates the rate value in the CTS packet sent to the transmitter. Furthermore and to ensure correct convergence of the Kalman filter, we propose a fuzzy logic approach to tune the parameters of the Kalman filter. The performance of the proposed scheme is tested and verified in a discrete event simulation environment.
L12 enhances gonococcal transcytosis of polarized Hec1B cells via the lutropin receptor.

We previously reported that gonococci convert to a more invasive phenotype (Inv(+)GC) following contact with cells expressing the lutropin receptor (LHr) and that Inv(+)GC express a novel adhesin that interacts with LHr. We propose that this adhesion allows Inv(+)GC to activate LHr and induce gonococcal transcytosis, usurping normal LHr function in fallopian and endometrial epithelium, which is to transport fetal chorionic gonadotropin (hCG) into the mother. Infected polarized Hec1B monolayers, grown on collagen-coated transwells, showed that the passage of GC across the monolayer occurred rapidly, within 30 min, and proceeded at a constant rate with Inv(+)GC passage three-fold faster than GC grown in tissue culture media alone (Inv(-)GC). Electron microscopy found that Inv(+)GC triggered pseudopod formation around the bacterium, with GC found throughout the Hec1B targets within 30 min, while Inv(-)GC did neither. Pre-treatment of Inv(-)GC with recombinant ribosomal protein L12, a gonococcal "hCG-like" protein previously shown to increase invasion, also increased Inv(-)GC transcytosis to the rate of Inv(+)GC. This enhancement was completely abolished by addition of luteinizing hormone, a cognate ligand of LHr. This is convincing evidence that surface expressed L12 mediates gonococcal invasion and transcytosis via LHr, a mechanism that could be important in the development of invasive gonococcal disease in women.
Effect of a hot environment on performance of prolonged, intermittent, high-intensity shuttle running

In this study we examined the performance during, and the physiological and metabolic responses to, prolonged, intermittent, high-intensity shuttle running in hot (∼30 C, dry bulb temperature) and moderate (∼20 C) environmental conditions. Twelve male students, whose mean (s x ) age, body mass and maximal oxygen uptake (V O 2m ax ) were 22 ± 1 years, 69.8 ± 01.8 kg and 56.9 ± 1.1 ml . kg ⊃1 . min ⊃1 respectively, performed intermittent high- and low-speed running involving five sets of ∼15 min of repeated cycles of walking and variable speed running followed by 60 s run/rest exercise until fatigue. The total distance completed in the hot and moderate trials was 8842 3790 m and 11,280 214 m respectively (P < 0.01). This decrement in performance occurred even though no differences existed in the level of dehydration, rating of perceived exertion, blood glucose and lactate, plasma free fatty acid and ammonia concentrations between the two trials. However, water consumption was almost twice as great in the ho.
Semi-blind signal separation and channel estimation in MIMO communication systems by tensor factorization

In this paper, we introduce a tensor-factorization method for signal detection in MIMO applications. We address the detection problem through a 3-way tensor analysis. We represent the 4 × 4 MIMO received signals as a third-order tensor with modes: receiver antennas, user data symbols at each packet, and finally number of packets. Then, we demonstrate that by multi-way analysis using PARAFAC2 we can successfully solve the blind MIMO signal detection problem. In order to solve the permutation and scaling ambiguities of the detected signals we used different M-Sequence training symbols are used. For evaluating the method we compared our BER results with those of MMSE-VBLAST signal detection method.
Clustering-Based Hyperspectral Band Selection Using Information Measures

Hyperspectral imaging involves large amounts of information. This paper presents a technique for dimensionality reduction to deal with hyperspectral images. The proposed method is based on a hierarchical clustering structure to group bands to minimize the intracluster variance and maximize the intercluster variance. This aim is pursued using information measures, such as distances based on mutual information or Kullback-Leibler divergence, in order to reduce data redundancy and non useful information among image bands. Experimental results include a comparison among some relevant and recent methods for hyperspectral band selection using no labeled information, showing their performance with regard to pixel image classification tasks. The technique that is presented has a stable behavior for different image data sets and a noticeable accuracy, mainly when selecting small sets of bands.
Online and incremental mining of separately-grouped Web access logs

The rising popularity of electronic commerce makes data mining an indispensable technology for business competitiveness. The World Wide Web provides abundant raw data in the form of Web access logs, Web transaction logs and Web user profiles. Without data mining tools, it is impossible to make any sense of such massive data. We focus on Web usage mining because it deals most appropriately with understanding user behavioral patterns which is the key to successful customer relationship management. Previous work dealt separately with specific issues of Web usage mining and made assumptions without taking a holistic view and thus, had limited practical applicability. We formulate a novel and more holistic version of Web usage mining termed transactionized logfile mining (TRALOM) to effectively and correctly identify transactions as well as to mine useful knowledge from Web access logs. We also introduce a new data structure, called the WebTrie, to efficiently hold useful preprocessed data so that TRALOM can be done in an online and incremental fashion. Experiments conducted on real Web server logs verify the usefulness and practicality of our proposed techniques.
Frameworks of Caring and Helping in Adolescence: Are Empathy, Religiosity, and Spirituality Related Constructs?

Caring and helping are suggested as mechanisms that link empathy to religiosity and spirituality. To test this assertion, 428 adolescents completed self-report measures of religious attendance, importance of spiritual or religious beliefs, care, volunteerism, and affective and cognitive subscales of empathy. Sex differences also were examined. Importance of beliefs was associated with empathic concern and perspective-taking forms of empathy. Unexpectedly, religious attendance was not related to either subscale of empathy. Through a series of regressions, care was shown to mediate the relations between importance of beliefs and empathic concern and perspective taking, and volunteerism mediated the relation between importance of beliefs and perspective taking. Care, especially, should continue to be examined for its bridging function between empathy and religiosity and spirituality. Gender role and biological sex distinctions should also be examined in future studies.
The Effect of Creatine Supplementation During Resistance Training in Women

Sixteen collegiate women lacrosse players consumed either creatine (C, n = 7) or a placebo (P, n = 9) for 5 weeks during their preseason conditioning program (20 g · d−1 for 1 week and 2 g · d−1 for 4 weeks). Pre-and posttesting consisted of body composition, muscle endurance test, blood lactate response to the endurance test, 1 repetition maximum (1RM) bench press and leg extension, and blood glutamyltransferase (GGL) and blood urea nitrogen (BUN). Testing revealed that 1RM bench press significantly increased in both groups, with the C group improving significantly more than the P group (6.2 ± 2.0 and 2.8 ± 1.8 kg). Percent body fat by skin-fold decreased significantly more in C than the P group (-1.2 ± 0.9 and 0.3 ± 0.8), but was not different by group by hydrodensitometry. No significant differences between groups were found for all other measures, but significant time effects were noted for body weight gain (0.5 ± 3.2 kg), 1RM leg extension (1.4 ± 4.1 kg), BUN (0.07 ± 0.03 mmol · L−1), total work during the muscle endurance test (283.5 ± 387.3 watts), and fat-free mass by skinfold (0.7 ± 1.2 kg). In summary, a regime of dietary creatine supplementation significantly improved upper-body strength gain and decreased the percent body fat as assessed by skinfold in women athletes engaged in a resistance-training program.
3D object classification system based on volumetric parts

This paper presents a 3D object classification system based on volumetric parts. As the constituents of 3D object, the parts are described by superquadric-based geons, which enables a more compact 3D object representation. In the developed classification system, the improved interpretation tree method is implemented for classification, where a set of novel integrated features and corresponding constraints are proposed, which not only reflect individual parts' shape, but model's topological structure among 3D parts. The constraints are used to define efficient interpretation tree search rules, and the feasible correspondences of unknown object data and the stored models are obtained. Then a similarity measure computation algorithm is proposed to evaluate the shape similarity of the correspondence. The classification system can achieve both whole match and partial match between unknown object data and 3D models with shape similarity ranks; particularly, focus match can be accomplished, in which different key parts may be labeled and all the matched models with corresponding key parts can be obtained. The performance of the presented 3D object classification system is evaluated with a series of experiments.
High Spatial Resolution Mid-Infrared Observations of Three Seyfert Galaxies

Images at 12.5 μm of nuclei of three nearby Seyfert galaxies—NGC 1275, NGC 4151, and NGC 7469—have been obtained with the 10 m Keck Telescope. NGC 7469 is resolved and deconvolution delineates a structure (<0.″04) × 0. ″08, or less than 13 × 26 pc at a position angle of 135°. From a comparison with structure seen at millimeter wavelengths, this structure is interpreted as a disk aligned with the molecular gas in the central few hundred parsecs of the galaxy. NGC 1275 and NGC 4151 are not resolved; limits on the sizes of these nuclei are 0. ″08 and 0. ″16, corresponding to physical spatial scales of 28 and 10 pc. The lower limits to the brightness temperatures implied by these size limits and the measured flux densities are within ∼50 K of the 12–25 μm color temperatures of these systems, as inferred from IRAS observations. The angular size limits are within a factor of 2 of the sizes required to spatially resolve thermal emission from dust heated by a central luminosity source. These sizes preclude significant contributions to the nuclear infrared emission from star-forming regions.