Miracle-dz/UniFAR-FTUs huggingface dataset:
CMOS Power Amplifier with Inter-Stage Matching Network Using Tournament-Shape Transformer

In this study, we propose a power amplifier(PA) structure using tournament-shape transformer as inter-stage matching network. The proposed inter-stage can reduce the effect of the parasitic components of the transistors while minimizing the effect of additional interconnect lines between a drive stage and a power stage. In addition, the tournament-shape transformer matching network optimizes the impedance transformation between the drive and power stages, thereby improving the driving capability of the drive stage. To verify the feasibility of the proposed structure, we designed the PA using 130-nm RF SOI CMOS process. All of the matching networks, including test pads, were fully integrated. The size of the designed PA was 2. 6mmx1.3 mm. The measured PldB, peak P.A. E. , and gain were 26.34 dBm, 38.1%, and 27.4 dB with the supply voltage 2. 5V. The power satisfied the WLAN S02.11n 2.2GHz64QAM of an EVM was 15.25 dBm.
Patterns of Medical Marijuana Use Among Individuals Sampled from Medical Marijuana Dispensaries in Los Angeles

Abstract The proliferation of medical marijuana (MM) dispensaries has led to concerns that they will lead to more widespread use of marijuana. The aim of the current study was to collect descriptive data on individuals using MM dispensaries in Los Angeles County. A mixed-method approach was employed that consisted of focus groups with 30 individuals and a survey of dispensary users (N = 182) in Los Angeles County. Differences between younger (less than 30 years old) and older individuals were examined in the survey sample. Most individuals in both samples had initiated marijuana use in adolescence. Nearly one-half of survey respondents had indications of risky alcohol use and one-fifth reported recent use of illicit drugs or misuse of prescription medications. Younger individuals had higher rates of tobacco use, visited dispensaries more frequently, and had more socially embedded patterns of use, but they were similar to older individuals in terms of their reasons for use. Nearly all participants believed that MM was beneficial in treating their health problems, although 65% reported symptoms of psychological distress in the past year. Interventions aimed at MM users should stress the related effects of tobacco and risky alcohol use as well as mental health needs.
Hedging Through a Limit Order Book with Varying Liquidity

Market impact is one of the most important aspects of real-world trading. It is typically a major component of transaction costs, and trading strategies are carefully optimized to minimize it. But most of the research has focused on one-off trades, not the repeated series of transactions required in delta-hedging an options position. In this article, the authors explore optimal hedging in an illiquid environment for a large trader whose trades absorb a nonmarginal fraction of the standing orders in the limit order book. The trader needs to take account of both the immediate price impact of each trade and the speed at which the limit order book is restored afterward—the market’s resilience. These two aspects of market dynamics together can produce a permanent effect of a big trade and also a temporary one that dissipates over time. Depending on the parameters of the liquidity process, the optimal strategy can be the canonical Black–Scholes delta hedge (in the limiting case of infinite liquidity) or one that is distinctly less volatile (when market impact is large, but there is some resilience in prices) or even one that entails price manipulation (when there is no resilience and the price impact is permanent).
Self-reinforced poly(lactic acid) nanocomposites with integrated bacterial cellulose and its surface modification

Abstract Bacterial cellulose (BC) nanofibers, with and without silane surface modification, were incorporated into self-reinforced poly(lactic acid) (SR-PLA) nanocomposites at 1 and 10 wt%. Disintegrated BC was combined with electrospun PLA fiber mats by film stacking and compression molding at 165 °C for 40 sec to obtain SR-PLA/BC hybrid films. The effect of nanocellulose addition and its surface modification on the structure, morphology, and properties of the resulting composites were investigated. It was found that BC was a highly effective reinforcement for SR-PLA nanocomposites, providing a noticeable increase in the film’s strength and modulus. Moreover, surface modification of BC was shown to further enhance the film performances due to an improved PLA/BC interfacial interaction. At an optimum BC content, these hybrid films also exhibited outstanding ductility and toughness. Water vapor barrier properties were also enhanced, especially when modified BC was integrated in the SR-PLA films. Graphical Abstract
High Speed, Micron Precision Scanning Technology for 3D Printing Applications

Modern 3D printing technology is becoming a more viable option for use in industrial manufacturing. As the speed and precision of rapid prototyping technology improves, so too must the 3D scanning and verification technology. Current 3D scanning technology (such as CT Scanners) produce the resolution needed for micron precision inspection. However, the method lacks in speed. Some scans can be multiple gigabytes in size taking several minutes to acquire and process. Especially in high volume manufacturing of 3D printed parts, such delays prohibit the widespread adaptation of 3D scanning technology for quality control. The limiting factors of current technology boil down to computational and processing power along with available sensor resolution and operational frequency. Realizing a 3D scanning system that produces micron precision results within a single minute promises to revolutionize the quality control industry. The specific 3D scanning method considered in this thesis utilizes a line profile triangulation sensor with high operational frequency, and a high-precision mechanical actuation apparatus for controlling the scan. By syncing the operational frequency of the sensor to the actuation velocity of the apparatus, a 3D point cloud is rapidly acquired. Processing of the data is then performed using MATLAB on contemporary computing hardware, which includes proper point cloud formatting and implementation of the Iterative Closest Point (ICP) algorithm for point cloud stitching. Theoretical and physical experiments are performed to demonstrate the validity of the method. The prototyped system is shown to produce multiple loosely-registered micron precision point clouds of a 3D printed object that are then stitched together to form a full point cloud representative of the original part. This prototype produces micron precision results in approximately 130 seconds, but the experiments illuminate upon the additional investments by which this time could be further reduced to approach the revolutionizing one-minute milestone.
Simultaneous Quantification of Active Carbon- and Nitrogen-Fixing Communities and Estimation of Fixation Rates Using Fluorescence In Situ Hybridization and Flow Cytometry

ABSTRACT Understanding the interconnectivity of oceanic carbon and nitrogen cycles, specifically carbon and nitrogen fixation, is essential in elucidating the fate and distribution of carbon in the ocean. Traditional techniques measure either organism abundance or biochemical rates. As such, measurements are performed on separate samples and on different time scales. Here, we developed a method to simultaneously quantify organisms while estimating rates of fixation across time and space for both carbon and nitrogen. Tyramide signal amplification fluorescence in situ hybridization (TSA-FISH) of mRNA for functionally specific oligonucleotide probes for rbcL (ribulose-1,5-bisphosphate carboxylase/oxygenase; carbon fixation) and nifH (nitrogenase; nitrogen fixation) was combined with flow cytometry to measure abundance and estimate activity. Cultured samples representing a diversity of phytoplankton (cyanobacteria, coccolithophores, chlorophytes, diatoms, and dinoflagellates), as well as environmental samples from the open ocean (Gulf of Mexico, USA, and southeastern Indian Ocean, Australia) and an estuary (Galveston Bay, Texas, USA), were successfully hybridized. Strong correlations between positively tagged community abundance and 14C/15N measurements are presented. We propose that these methods can be used to estimate carbon and nitrogen fixation in environmental communities. The utilization of mRNA TSA-FISH to detect multiple active microbial functions within the same sample will offer increased understanding of important biogeochemical cycles in the ocean.
An esophageal squamous cell carcinoma classification system that reveals potential targets for therapy

ESCC (Esophageal squamous cell carcinoma) is a heterogeneous cancer with diverse prognosis. Here, to explore the biological diversity of ESCC, we employed gene expression profiles from 360 ESCC tumors from East Asians to establish a comprehensive molecular classification and characterization of ESCC. Using the specific 185-gene signature generated by unsupervised consensus clustering of gene expression data, we defined four subtypes associated with distinct clinical metrics: tumors with high metastasis associated with EMT (epithelial to mesenchymal transition) and active MAP4K4/JNK signaling pathway; tumors with high chromosomal instability with up regulated MYC targes; well differentiated tumors with less aggressive and moderated tumors. The clinical relevance of these subtypes was stated by significant differences in prognosis. Importantly, 24% of all ESCCs (n = 360) were classified into the high metastasis subtype associated with poorly differentiation and unfavorable prognosis. We provided evidence that this subtype relates to tumor microenvironment. Collectively, these results might contribute to more precise personalized therapeutic strategies for each subtype of ESCC patients in the near future.
Norepinephrine and corticosterone in the medial prefrontal cortex and hippocampus predict PTSD‐like symptoms in mice

This study measured changes in brain extracellular norepinephrine (NE) and free corticosterone (CORT) levels in a mouse model of post‐traumatic stress disorder and related them to hyperarousal and fear memory retention. To this end, microdialysis in the medial prefrontal cortex (mPFC) and the hippocampus (HPC) of male C57BL/6NCrl mice was performed during an acoustic startle response (ASR) and following an electric foot shock (FS), as well as during an ASR and recall of contextual fear (CF) 1 day later. Changes in ASR‐stimulated NE levels in the mPFC corresponded to ASR 34 days after FS. Changes in basal and ASR‐stimulated extracellular NE levels in the HPC, in contrast, were related to expression of early (day 2) and late (day 34) CF after FS. The increase in extracellular NE levels correlated in a U‐shape manner with arousal levels and CF, thus suggesting a non‐direct relationship. Stress of different modalities/strength (ASR, FS and CF) caused a similar relative increase in free CORT levels both in the mPFC and the HPC. One day after FS, ASR‐induced increases in the CORT content in the mPFC tended to correlate with the FS‐potentiated ASR in a U‐shape manner. Taken together, these data show that the intracerebral increase in free CORT was likely related to an immediate response to stress, whereas NE neurotransmission in the forebrain predicted arousal and CF 1 month after trauma.
Structurally divergent histone H1 variants in chromosomes containing highly condensed interphase chromatin

Condensed and late-replicating interphase chromatin in the Dipertan insect Chironomus contains a divergent type of histone H1 with an inserted KAP-KAP repeat that is conserved in single H1 variants of Caenorhabditis elegans and Volvox carteri. H1 peptides comprising the insertion interact specifically with DNA. The Chironomid Glyptotendipes exhibits a corresponding correlation between the presence of condensed chromosome sections and the appearance of a divergent H1 subtype. The centromere regions and other sections of Glyptotendipes barbipes chromosomes are inaccessible to immunodecoration by anti-H2B and anti- H1 antibodies one of which is known to recognize nine different epitopes in all domains of the H1 molecule. Microelectrophoresis of the histones from manually isolated unfixed centromeres revealed the presence of H1 and core histones. H1 genes of G. barpipes were sequenced and found to belong to two groups. H1 II and H1 III are rather similar but differ remarkably from H1 I. About 30% of the deduced amino acid residues were found to be unique to H1 I. Most conspicuous is the insertion, SPAKSPGR, in H1 I that is lacking in H1 II and H1 III and at its position gives rise to the sequence repeat SPAKSPAKSPGR. The homologous H1 I gene in Glyptotendipes salinus encodes the very similar repeat TPAKSPAKSPGR. Both sequences are structurally related to the KAPKAP repeat in H1 I-1 specific for condensed chromosome sites in Chironomus and to the SPKKSPKK repeat in sea urchin sperm H1, lie at almost the same distance from the central globular domain, and could interact with linker DNA in packaging condensed chromatin.
Universal and Determined Constructors of Multisets of Objects

This paper contains analysis of creation of sets and multisets as an approach for modeling of some aspects of human thinking. The creation of sets is considered within constructive object-oriented version of set theory (COOST), from different sides, in particular classical set theory, object-oriented programming (OOP) and development of intelligent information systems (IIS). The main feature of COOST in contrast to other versions of set theory is an opportunity to describe essences of objects more precisely, using their properties and methods, which can be applied to them. That is why this version of set theory is object-oriented and close to OOP. Within COOST, the author proposes universal constructor of multisets of objects that gives us a possibility to create arbitrary multisets of objects. In addition, a few determined constructors of multisets of objects, which allow creating multisets, using strictly defined schemas, also are proposed in the paper. Such constructors are very useful in cases of very big cardinalities of multisets, because they give us an opportunity to calculate a multiplicity of each object and cardinality of multiset before its creation. The proposed constructors of multisets of objects allow us to model in a sense corresponding processes of human thought, that in turn give us an opportunity to develop IIS, using these tools.
Importance of N-Glycosylation on CD147 for Its Biological Functions

Glycosylation of glycoproteins is one of many molecular changes that accompany malignant transformation. Post-translational modifications of proteins are closely associated with the adhesion, invasion, and metastasis of tumor cells. CD147, a tumor-associated antigen that is highly expressed on the cell surface of various tumors, is a potential target for cancer diagnosis and therapy. A significant biochemical property of CD147 is its high level of glycosylation. Studies on the structure and function of CD147 glycosylation provide valuable clues to the development of targeted therapies for cancer. Here, we review current understanding of the glycosylation characteristics of CD147 and the glycosyltransferases involved in the biosynthesis of CD147 N-glycans. Finally, we discuss proteins regulating CD147 glycosylation and the biological functions of CD147 glycosylation.
Cloning of  Vascular Adhesion Protein 1 Reveals a Novel Multifunctional Adhesion Molecule

Vascular adhesion protein 1 (VAP-1) is a human endothelial sialoglycoprotein whose cell surface expression is induced under inflammatory conditions. It has been shown previously to participate in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin–independent fashion. We report here that the VAP-1 cDNA encodes a type II transmembrane protein of 84.6 kD with a single transmembrane domain located at the NH2-terminal end of the molecule and six potential N-glycosylation sites in the extracellular domain. In vivo, the protein exists predominantly as a homodimer of 170–180 kD. Ax endothelial cells transfected with a VAP-1 cDNA express VAP-1 on their cell surface and bind lymphocytes, and the binding can be partially inhibited with anti–VAP-1 mAbs. VAP-1 has no similarity to any currently known adhesion molecules, but has significant identity to the copper-containing amine oxidase family and has a monoamine oxidase activity. We propose that VAP-1 is a novel type of adhesion molecule with dual function. With the appropriate glycosylation and in the correct inflammatory setting, its expression on the lumenal endothelial cell surface allows it to mediate lymphocyte adhesion and to function as an adhesion receptor involved in lymphocyte recirculation. Its primary function in other locations where it is expressed, such as smooth muscle, may depend on its inherent monoamine oxidase activity.
A Hybrid Algorithm for Coalition Structure Generation

The current state-of-the-art algorithm for optimal coalition structure generation is IDP-IP — an algorithm that combines IDP (a dynamic programming algorithm due to Rahwan and Jennings, AAAI'08) with IP (a tree-search algorithm due to Rahwan et al., JAIR'09). In this paper we analyse IDP-IP, highlight its limitations, and then develop a new approach for combining IDP with IP that overcomes these limitations.
Differential Protein Expression in Congenital and Acquired Cholesteatomas

Congenital cholesteatomas are epithelial lesions that present as an epithelial pearl behind an intact eardrum. Congenital and acquired cholesteatomas progress quite differently from each other and progress patterns can provide clues about the unique origin and pathogenesis of the abnormality. However, the exact pathogenic mechanisms by which cholesteatomas develop remain unknown. In this study, key proteins that directly affect cholesteatoma pathogenesis are investigated with proteomics and immunohistochemistry. Congenital cholesteatoma matrices and retroauricular skin were harvested during surgery in 4 patients diagnosed with a congenital cholesteatoma. Tissue was also harvested from the retraction pocket in an additional 2 patients during middle ear surgery. We performed 2-dimensional (2D) electrophoresis to detect and analyze spots that are expressed only in congenital cholesteatoma and matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF/MS) to separate proteins by molecular weight. Protein expression was confirmed by immunohistochemical staining. The image analysis of 2D electrophoresis showed that 4 congenital cholesteatoma samples had very similar protein expression patterns and that 127 spots were exclusively expressed in congenital cholesteatomas. Of these 127 spots, 10 major spots revealed the presence of titin, forkhead transcription activator homolog (FKH 5–3), plectin 1, keratin 10, and leucine zipper protein 5 by MALDI-TOF/MS analysis. Immunohistochemical staining showed that FKH 5–3 and titin were expressed in congenital cholesteatoma matrices, but not in acquired cholesteatomas. Our study shows that protein expression patterns are completely different in congenital cholesteatomas, acquired cholesteatomas, and skin. Moreover, non-epithelial proteins, including FKH 5–3 and titin, were unexpectedly expressed in congenital cholesteatoma tissue. Our data indicates that congenital cholesteatoma origins may differ from those of acquired cholesteatomas, which originate from retraction pocket epithelia.
Factors Influencing Turning and Its Relationship with Falls in Individuals with Parkinson’s Disease

Background Falls are a major problem for people with Parkinson’s disease (PD). Many studies indicate that more than 50% of people with PD have difficulty in turning that may lead to falls during daily activities. The aims of this study were to identify the relationship between turning performance and falls, and to determine the factors that influence turning performance. Methods This study examined 45 patients with idiopathic PD (Hoehn and Yahr stage 1–3) using a battery of tests, including 180° turn time, balance, and muscle strength. The levels of disease severity and freezing of gait were also measured. The number of falls in the past 6 months was recorded. Results Sixteen out of forty-five participants experienced falls in the past 6 months. A receiver operating characteristic curve showed that turn time was highly related to falls [more affected side: sensitivity = 0.81, specificity = 0.79, area under the curve (AUC) = 0.83; less affected side: sensitivity = 0.88, specificity = 0.76, AUC = 0.83]. The most important factor influencing turn time was balance ability (both sides: p = 0.000) according to the regression model. Correlations between turn time and dynamic balance were further established with reaction time, movement velocity, endpoint excursion, and maximal excursion of the LOS (limits of stability) test. Conclusion The time needed to complete a 180° turn during the SQT (step/quick turn) test is a good index to differentiate fallers from non-fallers in persons with PD. Turn time is most influenced by balance. Furthermore, balance control, especially in an anterior or sideways direction, is important for turning performance.
Performance of local information-based link prediction: a sampling perspective

Link prediction is pervasively employed to uncover the missing links in the snapshots of real-world networks, which are usually obtained through different kinds of sampling methods. In the previous literature, in order to evaluate the performance of the prediction, known edges in the sampled snapshot are divided into the training set and the probe set randomly, without considering the underlying sampling approaches. However, different sampling methods might lead to different missing links, especially for the biased ways. For this reason, random partition-based evaluation of performance is no longer convincing if we take the sampling method into account. In this paper, we try to re-evaluate the performance of local information-based link predictions through sampling method governed division of the training set and the probe set. It is interesting that we find that for different sampling methods, each prediction approach performs unevenly. Moreover, most of these predictions perform weakly when the sampling method is biased, which indicates that the performance of these methods might have been overestimated in the prior works.