Miracle-dz/UniFAR-FTUs huggingface dataset:
CD4+ T Cells Support Production of Simian Immunodeficiency Virus Env Antibodies That Enforce CD4-Dependent Entry and Shape Tropism In Vivo

ABSTRACT CD4+ T cells rather than macrophages are the principal cells infected by human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) in vivo. Macrophage tropism has been linked to the ability to enter cells through CCR5 in conjunction with limiting CD4 levels, which are much lower on macrophages than on T cells. We recently reported that rhesus macaques (RM) experimentally depleted of CD4+ T cells before SIV infection exhibit extensive macrophage infection as well as high chronic viral loads and rapid progression to AIDS. Here we show that early-time-point and control Envs were strictly CD4 dependent but that, by day 42 postinfection, plasma virus of CD4+ T cell-depleted RM was dominated by Envs that mediate efficient infection using RM CCR5 independently of CD4. Early-time-point and control RM Envs were resistant to neutralization by SIV-positive (SIV+) plasma but became sensitive if preincubated with sCD4. In contrast, CD4-independent Envs were highly sensitive to SIV+ plasma neutralization. However, plasma from SIV-infected CD4+ T cell-depleted animals lacked this CD4-inducible neutralizing activity and failed to neutralize any Envs regardless of sCD4 pre-exposure status. Enhanced sensitivity of CD4-independent Envs from day 42 CD4+ T cell-depleted RM was also seen with monoclonal antibodies that target both known CD4-inducible and other Env epitopes. CD4 independence and neutralization sensitivity were both conferred by Env amino acid changes E84K and D470N that arose independently in multiple animals, with the latter introducing a potential N-linked glycosylation site within a predicted CD4-binding pocket of gp120. Thus, the absence of CD4 T cells results in failure to produce antibodies that neutralize CD4-independent Envs and CD4-pretriggered control Envs. In the absence of this constraint and with a relative paucity of CD4+ target cells, widespread macrophage infection occurs in vivo accompanied by emergence of variants carrying structural changes that enable entry independently of CD4.
Traction force microscopy of engineered cardiac tissues

Cardiac tissue development and pathology have been shown to depend sensitively on microenvironmental mechanical factors, such as extracellular matrix stiffness, in both in vivo and in vitro systems. We present a novel quantitative approach to assess cardiac structure and function by extending the classical traction force microscopy technique to tissue-level preparations. Using this system, we investigated the relationship between contractile proficiency and metabolism in neonate rat ventricular myocytes (NRVM) cultured on gels with stiffness mimicking soft immature (1 kPa), normal healthy (13 kPa), and stiff diseased (90 kPa) cardiac microenvironments. We found that tissues engineered on the softest gels generated the least amount of stress and had the smallest work output. Conversely, cardiomyocytes in tissues engineered on healthy- and disease-mimicking gels generated significantly higher stresses, with the maximal contractile work measured in NRVM engineered on gels of normal stiffness. Interestingly, although tissues on soft gels exhibited poor stress generation and work production, their basal metabolic respiration rate was significantly more elevated than in other groups, suggesting a highly ineffective coupling between energy production and contractile work output. Our novel platform can thus be utilized to quantitatively assess the mechanotransduction pathways that initiate tissue-level structural and functional remodeling in response to substrate stiffness.
A Mold Surface Treatment for Improving Surface Finish of Injection Molded Microcellular Parts

Micro-cellular foaming technology draws attention due to the enhancement of mechanical strength, which has been considered as a weak point of current plastic foaming technology. Foam materials produced by this technology offer improved consistency and homogeneity of cell structure, which can result in products with superior properties and uniformity(1). Thus it is widely used for commercial purposes and its market is now growing significantly. However, since the foamed injection parts have swirl marks on its surface, this technology has limited uses such as interior products, in spite of its diverse merits. In this paper, we propose surface treatment of the mold as a way to remove the swirl mark. We injected simple shape specimens with PP and PC/ABS materials and measured the surface quality values such as roughness and gloss. Also we researched the foaming characteristics of both treated and untreated surface using SEM analysis.
Reference Book on the Oxide Systems Space Diagrams as a Tool for Data Mining

The Reference Book of Ternary Oxide Systems phase diagrams computer models is presented. Its computer models of T-x-y diagrams give a possibility to calculate the mass balances at any temperature, to observe crystallization history and the process of microstructure forming at different crystallization stages. The investigation of concentration fields with the different phase constituents on the T-x-y diagram projection by means of its computer model is considered. Phase diagram of CaO-SiO2-Al2O3 system is used as an example.
Certification of an aircraft and airborne surveillance of fuel sulfur content in ships at the SECA border

In 2015 new rules from the IMO and legislation from EU (Sulfur directive) and the US requires ships to run with maximum fuel sulfur content (FSC) of 0.1 % m/m in northern European and North American waters. In order to promote a level playing field within the shipping sector, there is a need for measurement systems that can make effective compliance control and this is the main objective of the CompMon project, funded through the European CEF program (Connecting Europe Facility). As part of this project, a sensor system has been certified for ship surveillance measurements in a Piper Navajo aircraft and it has been demonstrated for airborne measurements of FSC in individual ships on the English Channel. The measurement system consists of an optical module which measures total emissions of SO2 and NO2 in g/s and a sniffer system by which FSC is retrieved from extractive measurements of SO2 and CO2. It can be used from fixed sites, patrol vessels and from aircraft. The advantage with airborne surveillance is the capability to check ships that are operating in the main shipping lanes, up to 200 nautical miles from shore. The precision of the estimated FSC from the sniffer system is 0.05 % m/m and hence at the 95 % confidence limit, ships above a FSC of 0.2 % m/m can be checked. The sniffer system also has a negative bias in the FSC of approx- imately 0.04 % m/m which is accounted for in the FSC calculations. The optical system has larger measurement uncertainties than the sniffer but it is intended mostly for guid- ance of other controls. As part of the CompMon project, a measurements campaign with the Navajo Piper aircraft was carried out at the SECA (Sulfur Emission Control Area) border in the English Channel at longitude 5 W. Six flight missions with duration of 4 to 5 hours were carried out from September 2 to 10, 2016, flying from Brest airport. In this manner it was possible to cover the longitude range 2o - 6o W. During the campaign, 114 ships were measured with the sniffer system, corresponding to 71 ships inside the SECA and 42 ships outside. The level of compli- ance inside the SECA was here 87 % and this is considerably lower than measurements carried out elsewhere within CompMon in other parts of the SECA (95-99 %). Two thirds of the non-complying vessels were leav- ing the SECA. With the optical system 110 individual ships were measured, 42 outside and 68 inside the SE- CA. The measurements show a similar pattern as the sniffer data but with a few false values. Nevertheless it is shown that both low and high FSC ships will be classified correctly with about 80-90 % probability with the optical system and this system is hence very promising as a tool to guide further compliance controls.
A Reliable and Reconfigurable Signal Processing Framework for Estimation of Metabolic Equivalent of Task in Wearable Sensors

Wearable motion sensors are widely used to estimate metabolic equivalent of task (MET) values associated with physical activities. However, one major obstacle in widespread adoption of current wearables is that any changes in configuration of the network requires new data collection and re-training of the underlying signal processing algorithms. For any wearable-based MET estimation framework to be considered a viable platform, it needs to be reconfigurable, reliable, and power-efficient. In this paper, we aim to address the issues of sensor misplacement, power efficiency, and new sensor addition and propose a reliable and reconfigurable MET estimation framework. We introduce a power-aware sensor localization approach that allows users to wear the sensors on different body locations without need for adhering to a specific installation protocol. Furthermore, we propose a novel transductive transfer learning approach, which gives end-users the ability to add new sensors to the network without need for collecting new training data. This is accomplished by transferring the knowledge of already trained sensors to the untrained sensors in real-time. Our experiments demonstrate that our sensor localization algorithm achieves an accuracy of 90.8% in detecting location of the wearable sensors. The integrated model of sensor localization and MET calculation achieves an R2 of 0.8 in estimating MET values using a regression-based model. Furthermore, our transfer learning algorithm improves the R2 value of MET estimation up to 60%.
Chasing Rhetorical Cues to Sarcasm in Online Debate

Rhetorical questions are frequently used in social media, aimed as capturing an audience’s attention or achieving a pragmatic goal, such as argumentation or persuasion. Although it has been observed that many of the uses of rhetorical questions are sarcastic, there is no large-scale computational work dedicated to distinguishing sarcastic from argumentative rhetorical questions, to our knowledge. To fill this gap, we expand on the only small existing dataset to include 2.5K rhetorical questions in debate forums. We use an LSTM model to distinguish between the classes, beating previous baselines with up to 0.75F for SARCASTIC and 0.76F for ARGUMENTATIVE, then analyze characteristic linguistic categories by class.
Autonomous active recognition and unfolding of clothes using random decision forests and probabilistic planning

We present a novel approach to the problem of autonomously recognizing and unfolding articles of clothing using a dual manipulator. The problem consists of grasping an article from a random point, recognizing it and then bringing it into an unfolded state. We propose a data-driven method for clothes recognition from depth images using Random Decision Forests. We also propose a method for unfolding an article of clothing after estimating and grasping two key-points, using Hough forests. Both methods are implemented into a POMDP framework allowing the robot to interact optimally with the garments, taking into account uncertainty in the recognition and point estimation process. This active recognition and unfolding makes our system very robust to noisy observations. Our methods were tested on regular-sized clothes using a dual-arm manipulator and an Xtion depth sensor. We achieved 100% accuracy in active recognition and 93.3% unfolding success rate, while our system operates faster compared to the state of the art.
The normative power of food promotions: Australian children’s attachments to unhealthy food brands

Abstract Objective The formation of food brand associations and attachment is fundamental to brand preferences, which influence purchases and consumption. Food promotions operate through a cascade of links, from brand recognition, to affect, and on to consumption. Frequent exposures to product promotions may establish social norms for products, reinforcing brand affect. These pathways signify potential mechanisms for how children’s exposure to unhealthy food promotions can contribute to poor diets. The present study explored children’s brand associations and attachments for major food brands. Design A cross-sectional online survey was conducted. Fourteen study brands were used, with each child viewing a set of seven logos. The questionnaire assessed perceptions of food brands and perceptions of users of brands, using semantic differential scales, and perceived brand ‘personalities’, using Likert scales. Setting New South Wales, Australia, October–November 2014. Subjects Children aged 10–16 years (n 417). Results Children demonstrated strong positive affect to certain brands, perceiving some unhealthy food brands to have positive attributes, desirable user traits and alignment to their own personality. Brand personality traits of ‘smart’ and ‘sporty’ were viewed as indicators of healthiness. Brands with these traits were ranked lower for popularity. Conclusions Children’s brand associations and attachments indicate the potential normative social influences of promotions. While children are aware of brand healthiness as an attribute, this competes with other brand associations, highlighting the challenge of health/nutrition messaging to counter unhealthy food marketing. Restricting children’s exposure to unhealthy food marketing and the persuasive nature of marketing is an important part of efforts to improve children’s diet-related health.
Anonymous Announcement System (AAS) for Electric Vehicle in VANETs

Vehicular Ad Hoc Network (VANET) allows vehicles to exchange information about road and traffic conditions through wireless communications. Nevertheless, providing reliable and authenticated information without violating the user’s privacy seems contradictory. In this paper, we propose an Anonymous Announcement System especially designed for Electric Vehicle (EV) in VANETs to achieve the aforementioned contradictory goals. We demonstrated the feasibility of the protocol with a prototype implementation on a suitable device and a network simulation with our protocol added on top of a normal VANET.
Comparison of outcomes using anatomic and reverse total shoulder arthroplasty.

UNLABELLED Worldwide, the usage of both anatomic total shoulder arthroplasty (aTSA) and reverse total shoulder arthro- plasty (rTSA) has increased significantly due, in part, to the predictability of acceptable outcomes achieved with each prosthesis type. This study quantifies outcomes using five different metrics and compares results using one platform total shoulder arthroplasty system that utilizes the same humeral component and instrumentation to perform both aTSA or rTSA. METHODS 200 patients were treated by two orthopaedic surgeons using either aTSA or rTSA. 73 patients received aTSA for treatment of osteoarthritis (OA), and 127 patients received rTSA for treatment of rotator cuff tear arthro- plasty (CTA). Each was scored preoperatively, and at latest follow-up using the SST, UCLA, ASES, Constant, and SPADI metrics, motion was also quantified. The average follow-up for all patients was 31.4 ± 9.7 months. RESULTS All patients demonstrated significant improvements in pain and function following treatment of OA with aTSA and treatment of CTA with rTSA. No instances of instability or glenoid loosening were reported in either cohort; one instance of infection occurred in the rTSA cohort. aTSA was associated with significantly higher pre- and postoperative outcome scores and significantly larger pre- and postoperative range of motion than rTSA. However, rTSA was demonstrated to be significantly more effective at improving outcome scores, active forward flexion, and strength than was aTSA. DISCUSSION AND CONCLUSIONS Significant improvements in outcome scores were observed for both aTSA and rTSA using one platform shoulder system at a mean follow-up of 31.4 months. Significant differences were observed between prosthesis type and between scoring metrics, particularly between the Constant and ASES scoring metrics. Additional and longer term follow-up is required to confirm these observed differences.
Benchmarking 6DOF Outdoor Visual Localization in Changing Conditions

Visual localization enables autonomous vehicles to navigate in their surroundings and augmented reality applications to link virtual to real worlds. Practical visual localization approaches need to be robust to a wide variety of viewing condition, including day-night changes, as well as weather and seasonal variations, while providing highly accurate 6 degree-of-freedom (6DOF) camera pose estimates. In this paper, we introduce the first benchmark datasets specifically designed for analyzing the impact of such factors on visual localization. Using carefully created ground truth poses for query images taken under a wide variety of conditions, we evaluate the impact of various factors on 6DOF camera pose estimation accuracy through extensive experiments with state-of-the-art localization approaches. Based on our results, we draw conclusions about the difficulty of different conditions, showing that long-term localization is far from solved, and propose promising avenues for future work, including sequence-based localization approaches and the need for better local features. Our benchmark is available at visuallocalization.net.
Bi-label Propagation for Generic Multiple Object Tracking

In this paper, we propose a label propagation framework to handle the multiple object tracking (MOT) problem for a generic object type (cf. pedestrian tracking). Given a target object by an initial bounding box, all objects of the same type are localized together with their identities. We treat this as a problem of propagating bi-labels, i.e. a binary class label for detection and individual object labels for tracking. To propagate the class label, we adopt clustered Multiple Task Learning (cMTL) while enforcing spatio-temporal consistency and show that this improves the performance when given limited training data. To track objects, we propagate labels from trajectories to detections based on affinity using appearance, motion, and context. Experiments on public and challenging new sequences show that the proposed method improves over the current state of the art on this task.
Cue-Responding Behaviors During Pharmacy Counseling Sessions With Patients With Asthma About Inhaled Corticosteroids: Potential Relations With Medication Beliefs and Self-Reported Adherence

ABSTRACT The aim of this study was to examine cue-responding behavior at the pharmacy while counseling about inhaled corticosteroids (ICS) in relation to medication adherence and medication beliefs. Patients with asthma aged ≥18 years using ICS were recruited from 12 pharmacies. Counseling sessions were video-recorded. Patients’ emotional and informational cues and pharmacists’ and pharmacy technicians’ cue-responding behaviors were coded using an expanded version of the Medical Interview Aural Rating Scale. The Beliefs about Medicines Questionnaire assessed patients’ ICS concern and necessity beliefs. Self-reported ICS adherence was measured by four questions. During the 86 sessions, patients expressed on average 2.3, mostly informational, cues (70.8%). In 26.7% of the sessions, no cues were expressed. Pharmacists’ and technicians’ responses to emotional cues (59.3%) were mostly inadequate, and to informational cues mostly appropriate (63.6%). Providing inappropriate information (20.3%) was related to higher concerns post session (p < .05), and cue exploration to higher self-reported adherence at 3 months (p < .05). Apparently, providers’ responses to patients’ cues might have therapeutic value. In addition, patients might need to be encouraged to ask questions and express their concerns.
Socioeconomic status, non-communicable disease risk factors, and walking speed in older adults: multi-cohort population based study

Abstract Objective To assess the association of low socioeconomic status and risk factors for non-communicable diseases (diabetes, high alcohol intake, high blood pressure, obesity, physical inactivity, smoking) with loss of physical functioning at older ages. Design Multi-cohort population based study. Setting 37 cohort studies from 24 countries in Europe, the United States, Latin America, Africa, and Asia, 1990-2017. Participants 109 107 men and women aged 45-90 years. Main outcome measure Physical functioning assessed using the walking speed test, a valid index of overall functional capacity. Years of functioning lost was computed as a metric to quantify the difference in walking speed between those exposed and unexposed to low socioeconomic status and risk factors. Results According to mixed model estimations, men aged 60 and of low socioeconomic status had the same walking speed as men aged 66.6 of high socioeconomic status (years of functioning lost 6.6 years, 95% confidence interval 5.0 to 9.4). The years of functioning lost for women were 4.6 (3.6 to 6.2). In men and women, respectively, 5.7 (4.4 to 8.1) and 5.4 (4.3 to 7.3) years of functioning were lost by age 60 due to insufficient physical activity, 5.1 (3.9 to 7.0) and 7.5 (6.1 to 9.5) due to obesity, 2.3 (1.6 to 3.4) and 3.0 (2.3 to 4.0) due to hypertension, 5.6 (4.2 to 8.0) and 6.3 (4.9 to 8.4) due to diabetes, and 3.0 (2.2 to 4.3) and 0.7 (0.1 to 1.5) due to tobacco use. In analyses restricted to high income countries, the number of years of functioning lost attributable to low socioeconomic status by age 60 was 8.0 (5.7 to 13.1) for men and 5.4 (4.0 to 8.0) for women, whereas in low and middle income countries it was 2.6 (0.2 to 6.8) for men and 2.7 (1.0 to 5.5) for women. Within high income countries, the number of years of functioning lost attributable to low socioeconomic status by age 60 was greater in the United States than in Europe. Physical functioning continued to decline as a function of unfavourable risk factors between ages 60 and 85. Years of functioning lost were greater than years of life lost due to low socioeconomic status and non-communicable disease risk factors. Conclusions The independent association between socioeconomic status and physical functioning in old age is comparable in strength and consistency with those for established non-communicable disease risk factors. The results of this study suggest that tackling all these risk factors might substantially increase life years spent in good physical functioning.