Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence and clustering of menopausal symptoms in older women by hysterectomy and oophorectomy status.

This study examines the association of hysterectomy and oophorectomy with the prevalence and clustering of menopausal symptoms in a large population-based sample of older women. Subjects were 1121 women aged 50-89 from the Rancho Bernardo Study. Information on menopause, hysterectomy, oophorectomy, estrogen use, and other covariates was obtained in 1984-1987. A 1989 mailed survey obtained information on menopausal symptoms. In this sample, 22.1% reported hysterectomy with bilateral oophorectomy, and 25.3% reported hysterectomy with ovarian conservation. Mean time since hysterectomy was 26 (+/-12) years. Overall, 37% reported current estrogen use, and 40% reported past use. The duration of estrogen use was longer for women who had a hysterectomy (p < 0.001). Age-adjusted comparisons indicated that more women who had a hysterectomy, with or without bilateral oophorectomy, reported greater energy after menopause (p = 0.003 and p = 0.001, respectively), and more women with bilateral oophorectomy reported greater interest in sex (p = 0.007) and that life was getting better (p = 0.012) than women with natural menopause. Principal components factor analysis of the symptom data for all women yielded four factors: psychological, vasomotor, positive feelings, and self-image. Analyses performed within each group of women yielded similar factors and loadings. Adjusted comparisons of factor scores indicated that positive feelings were significantly higher in women who had a hysterectomy, with or without bilateral oophorectomy (p < 0.01) than in women with natural menopause. This difference was limited to current estrogen users. Vasomotor symptoms, psychological symptoms, and negative self-image did not differ by hysterectomy or oophorectomy status before or after stratification for estrogen use (p > 0.10). This study found after a hysterectomy, women are more likely to recall positive feelings about their menopause than women with natural menopause. Relief from symptoms leading to hysterectomy and use of replacement estrogen may be partly responsible. Results do not support the thesis that surgical menopause is associated with a sustained increased prevalence of vasomotor, psychological, or other symptoms.
Matrin3: connecting gene expression with the nuclear matrix

As indicated by its name, Matrin3 was discovered as a component of the nuclear matrix, an insoluble fibrogranular network that structurally organizes the nucleus. Matrin3 possesses both DNA‐ and RNA‐binding domains and, consistent with this, has been shown to function at a number of stages in the life cycle of messenger RNAs. These numerous activities indicate that Matrin3, and indeed the nuclear matrix, do not just provide a structural framework for nuclear activities but also play direct functional roles in these activities. Here, we review the structure, functions, and molecular interactions of Matrin3 and of Matrin3‐related proteins, and the pathologies that can arise upon mutation of Matrin3. WIREs RNA 2016, 7:303–315. doi: 10.1002/wrna.1336
Diagnosis and management of the metabolic syndrome in obesity

The metabolic syndrome is a constellation of interrelated abnormalities that increase the risk for cardiovascular disease and progression to type 2 diabetes. The prevalence of this syndrome is increasing because of the ‘obesity epidemic’. The National Cholesterol Education Program Adult Treatment Panel III defined practical criteria for the diagnosis of the metabolic syndrome and established the basic principles for its management. Also, the International Diabetes Federation recently proposed another definition. The metabolic syndrome is a secondary target for cardiovascular risk reduction. Clinicians should identify individuals with this condition, assess their cardiovascular risk and treat them by an aggressive and multifaceted approach. The most effective therapeutic intervention in patients with the metabolic syndrome should focus on modest weight reduction and regular physical activity. Adoption of a healthier diet and smoking cessation are necessary. Drug therapy may be needed to achieve recommended goals if therapeutic lifestyle changes are not sufficient. Low‐density lipoprotein cholesterol is the primary target of therapy (new aggressive goals should be achieved). Statins are probably the drugs of choice. Fibrates and nicotinic acid are also useful options. Hypertension should be managed aggressively probably starting with an inhibitor of the renin‐angiotensin system or a calcium channel blocker and adding a low dose of a thiazide diuretic if necessary. Aspirin should be administered if the cardiovascular risk is high. In the future acarbose, metformin, meglitinides and thiazolidinediones may be used in patients with the metabolic syndrome to delay the onset of type 2 diabetes and reduce cardiovascular risk. Such an intense and multifactorial approach is likely to reverse the bad prognosis associated with the metabolic syndrome.
Best Practice BRT for Increase TransJakarta Modal Share

TransJakarta since 2004 was expected as the backbone of the public transportation in Jakarta as well as TransMilenio in Bogota. However, the role of TransJakarta only approximately 1, 95% of the overall number of trips has reached 19 million/day. The analysis technique on this paper is descriptive analysis. TransJakarta operational perceived is still not effective, so that the necessary efforts to increase modal share sourced from BRT management best practice in other countries. Efforts could be made to increase modal share, among others, the elimination of thousands of parking and replaced by pedestrian friendly also develop a separate bike lane along 303 km in Bogota (Colombia). TransJakarta operational is still considered less in some aspects that are: total of fTransJakarta fleet, total of feeder route, Transjakarta speed and headway still need improved, overtaking lanes are built along the TransJakarta route, Integration with all public transport is absolutely necessary, integration with pedestrians and bicycle users TransJakarta ticket fares should be integrated with feeder and other public transportation such as KRL, city buses and paratransit and using smartcards. In terms of restrictions on the use of private vehicles can be done in the following ways implement a bike-sharing program, implement program of not using motor vehicles during weekdays for 1 day in a week, providing park and ride, implement fuel restriction program for gasoline purchases, implement car sharing program. If the operational performance of TransJakarta has been improved and restrictions on the use of private motor vehicles are implemented, it is expected that the modal split of road users in Jakarta can be expected to rise to be more ideal. In some other parts of the world some experts say ideal conditions of split capital between public transport and private vehicles can reach 65%: 35%. Hopefully the city of Jakarta can achieve this .
Static state feedback triangular block decoupling for arbitrary systems: a state-space method

ABSTRACT In this paper, the static state feedback triangular block decoupling problem for a general system described by (A, B, C, D) quadruples is studied. Necessary and sufficient conditions which are numerically verifiable are obtained and a numerically reliable decoupling method is established in the state space. Two examples are solved by our method which show the effectiveness.
Continuous multistep synthesis of perillic acid from limonene by catalytic biofilms under segmented flow

The efficiency of biocatalytic reactions involving industrially interesting reactants is often constrained by toxification of the applied biocatalyst. Here, we evaluated the combination of biologically and technologically inspired strategies to overcome toxicity‐related issues during the multistep oxyfunctionalization of (R)‐(+)‐limonene to (R)‐(+)‐perillic acid. Pseudomonas putida GS1 catalyzing selective limonene oxidation via the p‐cymene degradation pathway and recombinant Pseudomonas taiwanensis VLB120 were evaluated for continuous perillic acid production. A tubular segmented‐flow biofilm reactor was used in order to relieve oxygen limitations and to enable membrane mediated substrate supply as well as efficient in situ product removal. Both P. putida GS1 and P. taiwanensis VLB120 developed a catalytic biofilm in this system. The productivity of wild‐type P. putida GS1 encoding the enzymes for limonene bioconversion was highly dependent on the carbon source and reached 34 g Ltube−1 day−1 when glycerol was supplied. More than 10‐fold lower productivities were reached irrespective of the applied carbon source when the recombinant P. taiwanensis VLB120 harboring p‐cymene monooxygenase and p‐cumic alcohol dehydrogenase was used as biocatalyst. The technical applicability for preparative perillic acid synthesis in the applied system was verified by purification of perillic acid from the outlet stream using an anion exchanger resin. This concept enabled the multistep production of perillic acid and which might be transferred to other reactions involving volatile reactants and toxic end‐products. Biotechnol. Bioeng. 2017;114: 281–290. © 2016 Wiley Periodicals, Inc.
A Structural Model of the Membrane‐Bound Aromatic Prenyltransferase UbiA from E. coli

The membrane‐bound enzyme 4‐hydroxybenzoic acid oligoprenyltransferase (ubiA) from E. coli is crucial for the production of ubiquinone, the essential electron carrier in prokaryotic and eukaryotic organisms. On the basis of previous modeling analyses, amino acids identified as important in two putative active sites (1 and 2) were selectively mutated. All mutants but one lost their ability to form geranylated hydroxybenzoate, irrespective of their being from active site 1 or 2. This suggests either that the two active sites are interrelated or that they are in fact only one site. With the aid of the experimental results and a new structure‐based classification of prenylating enzymes, a relevant 3D model could be developed by threading. The new model explains the substrate specificities and is in complete agreement with the results of site‐directed mutagenesis. The high similarity of the active fold of UbiA‐transferase to that of 5‐epi‐aristolochene synthase (Nicotiana tabacum), despite a low homology, allows a hypothesis on a convergent evolution of these enzymes to be formed.
Developing performance excellence guidance for rural tourism (case study: wangun lestari village, Bandung, West Java, Indonesia)

In response to Indonesian Ministry of Tourism objective to develop and improve the performance of tourism destination, specifically on rural tourism, Where there is no well-prepared implementation yet by the local government due to constrained human resources and lack of management knowledge and stakeholders. This research aims to develop an integrated rural tourism concept at Wangun Lestari Tourism Village. The Guideline of Rural Tourism Development of Ministry of Tourism, Malcolm Baldrige’s Performance Excellence, SWOT Analysis, and Value Proposition Analysis will be used to help to design the Rural Tourism program. The result of this research is a comprehensive concept of Leadership, Strategic Planning, Customer Management System, Knowledge Management, Workforce Engagement, Operation Focus and also Evaluation Metric for Wangun Lestari Tourism Village.
The genetic landscape on manifolds from human genes

The high throughput sequencing technology generates large amount of data and the computational methods therefore play important roles in bioinformatics research. This paper reports the findings from the result of analysing human genetic information by three manifold learning algorithms and two clustering methods. We target the genes that relate to human intelligence, selecting 38 of them, and marking them on the visualisation results.
Distributed information retrieval for Multi-XML document based on keywords

This article proposed a new approach for automatically correcting queries over Multi-XML, called MXDR(Multi-XML Distributed Retrieval). We first classed multi-XML documents by a clustering method, and elicited the common structure information. Then generated certifiable structured queries by analyzing the given keywords query and the common structure information of XML datasets. We can evaluate the generated structured queries over the XML data sources with any existing structure search engine.
Highly Variable Spread Rates in Replicated Biological Invasions: Fundamental Limits to Predictability

Limits to Invasion Predictions Using mathematical models linked to experiments on laboratory insect populations, Melbourne and Hastings (p. 1536) show that current models seriously underestimate variability in spatial spread. Genetic founder effects resulting from small population sizes are probably responsible for the surprising increase in variability and for increased uncertainty of ecological forecasts. Thus, even without exogenous sources of variability such as weather, fundamental uncertainties arise biologically from inherent differences among individuals and small population sizes. Replicated invasions in laboratory microcosms demonstrate inherent unpredictability due to randomness in biological processes. Although mean rates of spread for invasive species have been intensively studied, variance in spread rates has been neglected. Variance in spread rates can be driven exogenously by environmental variability or endogenously by demographic or genetic stochasticity in reproduction, survival, and dispersal. Endogenous variability is likely to be important in spread but has not been studied empirically. We show that endogenously generated variance in spread rates is remarkably high between replicated invasions of the flour beetle Tribolium castaneum in laboratory microcosms. The observed variation between replicate invasions cannot be explained by demographic stochasticity alone, which indicates inherent limitations to predictability in even the simplest ecological settings.
The Effects of Water on the Dielectric Properties of Silicon-Based Nanocomposites

A series of polyethylene-based nanocomposites was prepared, utilizing silicon nitride or silicon dioxide (silica) nanopowders, and the effect of filler loading and conditioning (i.e., water content) on their morphology and electrical properties was examined. The addition of nanosilicon nitride led to systems that were free of obvious nanoparticle aggregates, whereas the nanosilica-based systems showed evidence of aggregation up to the micrometer scale. While the nanosilicon nitride composites remained essentially dry under ambient conditions, the nanosilica-based composites absorbed appreciable quantities of water from the ambient environment, indicating that interactions with water are dependent on the nanoparticle surface chemistry. Dielectric spectroscopy showed a broad relaxation peak due to adsorbed water at nanoparticle surfaces, which shifted to higher frequencies with increased water content. Similarly, the electrical conductivity was found to be highly sensitive to the presence of absorbed water, particularly for systems containing well-dispersed nanoparticles. We conclude that, in nanodielectric applications, nanoparticle surface chemistry is important in determining macroscopic properties, and not just as a means of compatibilizing the filler and the matrix. Additional factors can be critical, here, as exemplified by interactions with water.
Solid-phase microextraction/gas-chromatographic/mass spectrometric analysis of p -dichlorobenzene and naphthalene in honey

Protection of honeycombs from the Wax moth, Galleria mellonella, involves the use of physical, biological or chemical control methods. As chemical control may result in residues in the extracted honey, the presence of p-dichlorobenzene and naphthalene residues was investigated by solid-phase microextraction (SPME) coupled to gas-chromatographic/mass spectrometry (GC/MS). The method was linear between 5 and 200 µg kg–1 honey for p-dichlorobenzene and 1 and 200 µg kg–1 for naphthalene. Limits of detection were 1 and 0.1 µg kg–1, respectively, for p-dichlorobenzene and naphthalene, while relative standard deviations were 2.6 and 7.9%, respectively. Application of the method to 90 unifloral Greek honeys revealed that, in 25.6% of the samples, the concentration of either one of the pesticides exceeded the maximum residue level (MRL). Maximum concentrations were 163.03 µg kg–1 honey for p-dichlorobenzene and 193.74 µg kg–1 honey for naphthalene. Naphthalene was found in traceable amounts in 78.9% of the samples, but only 5.6% of them contained concentrations above the MRL, which indicates the use of pre-contaminated honeycomb foundations or built combs. Nevertheless, because naphthalene is naturally present in some plant species growing in Greece, the contribution of nectar from such a floral source should not be overlooked.
Languages and Interaction Techniques for the Visualization and Manipulation of Massive Datasets. (Langages et techniques d'interaction pour la visualisation et la manipulation de masses de données)

Les recentes avancees en matiere d'acquisition, stockage et traitement des donnees ont resulte en une augmentation spectaculaire de la quantite d'information collectee et analysee, et ce dans de nombreux domaines : disciplines scientifiques, industrie, commerce, bibliotheques numeriques, donnees mises a disposition du public par des organismes gouvernementaux ; domaines auxquels s'ajoutent les contenus que tout un chacun peut mettre a disposition sur le Web a travers les reseaux sociaux, les blogs ou les sites de partage de documents multimedia. La capacite des systemes et bases de donnees heterogenes d'echanger et croiser ces donnees, mais aussi d'inferer de nouvelles donnees, s'est aussi grandement amelioree, grâce a des technologies emergentes comme celles issues des recherches liees au Web des donnees -- par opposition au Web des documents -- s'appuyant sur les technologies du Web semantique. Mes travaux de recherche s'inscrivent dans le domaine de l'interaction homme-machine (IHM), et portent plus specifiquement sur la conception, le developpement et l'evaluation de techniques d'interactions et de visualisation facilitant la comprehension et la manipulation de ces masses de donnees. Les representations graphiques peuvent etre d'une grande aide quand elles fournissent des visualisations pertinentes des donnees, de leur structure, et qu'elles sont couplees a des techniques d'interaction permettant une navigation efficace dans ces grands espaces d'information. Elles jouent a ce titre un role important dans la recherche et le developpement de systemes informatiques pour la gestion et l'analyse de masses de donnees semi-structurees. Mes activites de recherche sont organisees autour de deux themes, dont je presenterai les principaux resultats : langages visuels et techniques de visualisation d'information pour aider les utilisateurs a interpreter et manipuler des jeux de donnees semi-structures ; conception, developpement et evaluation experimentale de techniques d'interaction multi-echelle pour naviguer dans des masses de donnees sur differents types de plate-formes : dispositifs mobiles, stations de travail, murs d'images tres haute resolution.
Implication of Credit Supervision Practices on Portfolio at risk of Microfinance Institutions in Tanzania

This study seeks to establish the implication of credit supervision practices on portfolio management of microfinance institutions in Tanzania. Utilizing multivariate regression technique over sampled 219 microfinance institutions from Dar es Salaam, Morogoro and Dodoma regions, it documents two plausible results. First, the study finds that timely loan release and number of borrowers per loan officer have positive and statistically significant impact on portfolio at risk of microfinance institutions. Second, it reveals that operation cost per borrower and provision of training sessions to borrowers have negative and statistically significant impact on portfolio at risk of microfinance institutions. These results suggest that microfinance institutions can diminish portfolio risks by (1) decreasing number of days for processing clients’ loan applications and releasing funds; (2) decreasing number of clients per each loan officer in order to increase efficiency of loan management of the officers; (3) increasing training sessions on various skills given to their borrowers which will increase knowledge and skills of clients on the best ways to keep their business records and proper utilization of funds, and so successful repayments; (4) allocating enough budgets for overall supervisory purposes including loan appraisal processes, disbursement procedures and collection of funds from their clients.
Microwave sterilization of vials.

Due to different dielectric loss factors between glass and cell tissue, microwaves should primarily heat the microorganisms without intensive heating of the vials. A time and energy saving method for sterilization should therefore be possible by the use of microwave heating. Spores of B. subtilis and B. Stearothermophilus were applied to the vials which were treated with microwaves for different periods of time. The reduction of microorganisms by microwave treatment was determined. The reduction factor for B. subtilis was determined to more than 1O12 within 3 min of treatment with microwaves.
EFFECT OF JOB CHARACTERISTICS ON TEACHER PERFORMANCE IN PUBLIC PRIMARY SCHOOLS IN KAKAMEGA EAST SUB COUNTY

This study sought to establish the relationship between job characteristics and performance of teachers in Public Primary Schools in Kakamega East Sub County. The study adopted a descriptive survey design in which 289 teachers were sampled from public primary schools in Kakamega East Sub-County. The study adopted simple random sampling to obtain respondents from the study population. Study data was collected using a standard questionnaire. Validity of data collection instruments was ascertained using a pilot study while reliability was ascertained using test-re-test method. Study data was analysed using descriptive and inferential statistics with the aid of the Statistical Product and Service Solutions (SPSS) version 23 for windows. All statistical measurements were performed within 95% confidence interval. T he study found a statistically significant relationship between job characteristics and teacher performance in public primary schools in Kakamega East Sub-County. The study recommended that school management should ensure that school environment is conducive for teachers to ensure intrinsic motivation and satisfaction with their jobs. This can be achieved by ensuring that there are adequate teaching and learning resources as well as offering incentives to teachers and rewarding them for good performance. Key Words: Job Characteristics, Autonomy, Feedback, Teacher Performance