Miracle-dz/UniFAR-FTUs huggingface dataset:
BL-P1654, Ticarcillin, and Carbenicillin: In Vitro Comparison Alone and in Combination with Gentamicin Against Pseudomonas aeruginosa

Minimum inhibitory concentrations of carbenicillin, ticarcillin, and BL-P1654 were determined for 89 clinical isolates of Pseudomonas aeruginosa. Ticarcillin was generally twice as active and BL-P1654 eight to 16 times as active as carbenicillin. Usually carbenicillin and ticarcillin killed at the same concentration or twice the concentration needed to inhibit, whereas 400 μg of BL-P1654 per ml was not bactericidal for the majority of isolates tested. The inhibitory effect of all three drugs varied markedly with the size of bacterial inoculum. When therapeutically achievable concentrations were used, adding gentamicin enhanced the inhibitory and bactericidal activity of all three penicillin derivatives for the majority of isolates. However, inhibition of isolates highly resistant to gentamicin was not improved by combining the semisynthetic penicillins with gentamicin.
Hybrid designs for non-volatile embedded memory cells

Memory design has radically changed in the last few years; the emergence of new technologies has further improved performance and the traditional separation of storage levels between Static Random Access Memory (SRAM) and Dynamic Random Access Memory (DRAM) is not viable as in the past. Recently, the embedded DRAM (eDRAM) has been proposed for cache utilization to improve density while attempting to retain high performance operations; this scheme is often referred to as hybrid due to the utilization of different technologies in a memory. In this paper, a hybrid scheme is proposed by adding non-volatile features and related circuits to the SRAM/eDRAM; an Oxide Resistive Random Access Memory (RRAM) is utilized as non-volatile storage in the embedded memory circuit. Different memory cells are proposed in this manuscript; they are evaluated with respect to circuit-level figures of merit as related to operational features (read, write, static noise margin, power delay product) as well as tolerance to event upsets (critical charge and SER analysis) and variations. Extensive simulation results using nanometric PTMs are provided.
Oblivious router policies and Nash equilibrium

Most of congestion control schemes require users to behave in a cooperative way, so that they respect some "social responsible" rules. However, without forcing end users to adopt a centralized mandated algorithm controlling their behavior (which is not advisable), it is not possible to guarantee that they will not act in a selfish manner. Consequently, a fundamental issue is to evaluate the impact of having users that act in such a manner. In such a scenario, having a Nash equilibrium guarantees that no selfish user has incentive to unilaterally deviate from its current state (i.e., it guarantees that we are in a stable state in the presence of selfish users). However, here we formally prove that an efficient Nash equilibrium can not be reached in practice for any oblivious control policy.
Spatial variation in search engine queries

Local aspects of Web search - associating Web content and queries with geography - is a topic of growing interest. However, the underlying question of how spatial variation is manifested in search queries is still not well understood. Here we develop a probabilistic framework for quantifying such spatial variation; on complete Yahoo! query logs, we find that our model is able to localize large classes of queries to within a few miles of their natural centers based only on the distribution of activity for the query. Our model provides not only an estimate of a query's geographic center, but also a measure of its spatial dispersion, indicating whether it has highly local interest or broader regional or national appeal. We also show how variations on our model can track geographically shifting topics over time, annotate a map with each location's "distinctive queries", and delineate the "spheres of influence" for competing queries in the same general domain.
Regarding Gender: Essentialism, Constructionism, and Feminist Psychology

This article attempts to clarify two alternative understandings of gender—the essentialist and the constructionist—and to discuss the implications of each for feminist psychology. Essentialist construals of gender, represented by recent “cultural feminist” positions, are critiqued for the theoretical, empirical, and political concerns they raise. A constructionist position is offered as ameliorative, and lingering questions raised by this analysis are discussed.
Estimation of the minimum shielding failure current causing flashover in overhead lines of the hellenic transmission system through ATP-EMTP simulations

ATP-EMTP simulations are performed to estimate the minimum shielding failure current causing flashover in 150 kV and 400 kV double-circuit overhead lines of the Hellenic transmission system. This critical current is of great importance for estimating the shielding failure flashover rate and assessing the insulation coordination of overhead transmission lines. It is shown that the minimum shielding failure current causing flashover varies significantly among the insulator string flashover models employed in simulations, which include volt-time curves and leader development models. The minimum shielding failure current causing flashover calculated on the basis of the relevant IEEE Std is significantly lower than that obtained through ATP-EMTP simulations. The computed shielding failure flashover rate of the 150 kV and 400 kV overhead transmission lines is greatly affected by the method adopted for the estimation of the minimum shielding failure current causing flashover.
Use of cost effective and rapid molecular tools for identification of Candida species, opportunistic pathogens

Background and Purpose : Candidiasis is a widespread fungal infection caused by different Candida species. Rapid identification of Candida species in clinical laboratory is becoming increasingly important since the identification and discrimination of ethological agents for early treatment. We aimed at molecular identification of commonly Candida species isolated from clinical samples by using both PCR-RFLP assay and amplification of hwp1 gene. Materials and Methods: Clinical samples comprising of vaginal specimens ,cutaneous, sputum, bronchoalveolar lavage(BAL,( and blood cultures were recovered from suspected patients. Candida isolates were initially identified phenotypically and confirmed by molecular approaches based on restriction fragment length polymorphism (PCR-RFLP (with MspI restriction enzyme. Amplification of hwp1 gene was performed for discrimination of C. albicans from C. dubliniensis and C. africana. Results: The most abundant species were C. albicans (n=67; 44.6 %), C. glabrata (n=10; 20 %), C. tropicalis (n=20; 13.3 %), C. krusei (n=12; 8 %), C. parapsilosis (n=11; 7.3 %). Out of 67 C. albicans species, 6 species identified as C. dubliniensis and 4 species identified as C. africana. Conclusion: High frequency of non-albicans Candida species and differences in levels of susceptibility to the antifungal agents are important issues in medicine . Therefore, to manage the Candida-related infections properly, molecular diagnostic methods would be fast, reliable and even cost-effective approaches for identification of Candida species.
Hyperphosphorylation of mutant influenza virus matrix protein, M1, causes its retention in the nucleus

The matrix (M1) protein of influenza virus is a major structural component, involved in regulation of viral ribonucleoprotein transport into and out of the nucleus. Early in infection, M1 is distributed in the nucleus, whereas later, it is localized predominantly in the cytoplasm. Using immunofluorescence microscopy and the influenza virus mutant ts51, we found that at the nonpermissive temperature M1 was retained in the nucleus, even at late times after infection. In contrast, the viral nucleoprotein (NP), after a temporary retention in the nucleus, was distributed in the cytoplasm. Therefore, mutant M1 supported the release of the viral ribonucleoproteins from the nucleus, but not the formation of infectious virions. The point mutation in the ts51 M1 gene was predicted to encode an additional phosphorylation site. We observed a substantial increase in the incorporation of 32Pi into M1 at the nonpermissive temperature. The critical role of this phosphorylation site was demonstrated by using H89, a protein kinase inhibitor; it inhibited the expression of the mutant phenotype, as judged by M1 distribution in the cell. Immunofluorescence analysis of ts51-infected cells after treatment with H89 showed a wild-type phenotype. In summary, the data indicated that the ts51 M1 protein was hyperphosphorylated at the nonpermissive temperature and that this phosphorylation was responsible for its aberrant nuclear retention.
3D safe and intelligent trajectory generation for multi-axis machine tools using machine vision

Multi-axis high speed production technology importance and complexity is increasing with the increasing demand of its intelligence. Lack of proper automation and intelligence may cause collision risks, time delays and production interruption. Collision is an important problem for multi-axis machines because the current machine technology lacks the proper feedback communication process and hence a minor difference between a real and virtual scene may cause collision in real production. Similarly, minor operator mistakes and complexity of the Computer Aided Design or Manufacturing (CAD/CAM) process can cause collisions in virtual production simulations. Current CAM software and multi-axis machines are capable of detecting collision but are unable to provide safe paths intelligently for its avoidance. This paper uses image processing techniques and CAD/CAM data in order to define safe simulated trajectories for online/off-line virtual production extendible to real production. The 3D Rectangular Enveloped object Safe and Intelligent Trajectory (3D-RESIT) algorithm has been developed to generate safe and intelligent 3D transversal trajectories for virtual preparation by detecting and avoiding collision intelligently. The approach takes three images from the 3D machine model, interprets trajectories from the CAM (G-code), captures the trajectory and objects positions in 3D, detects collisions and provides many intelligent solutions to avoid the same collision process and finally selects the feasible solution. The final results are validated by applying the generated trajectories points back to CAM software simulations for verification.
1st International Workshop on Multilingual Web Access (MWA 2015)

Over the past 25 years, the World Wide Web has developed into a truly transnational information medium for users from across the globe. As of July 2013, Asia accounts for the largest share of online users in the world at 48%, followed by 22% from the Americas, and 19% from Europe. With this global development, the diversity of user languages on the Web has increased dramatically, leading to new challenges and opportunities for information access providers and consumers. The Multilingual Web Access (MWA 2015) workshop brought together researchers working on Cross-/Multilingual Search & Discovery, the Multilingual Social Web, as well as the Multilingual Semantic Web, in order to promote the exchange of complementary ideas and applicable/transferrable techniques between these areas. The goal of the workshop was to advance the current state of the art in Multilingual Web Access techniques, and, most importantly, to increase the adoption of multilingual techniques, methods, and tools in real-world Web applications.
An Adaptive Fault-Tolerant Memory System for FPGA-based Architectures in the Space Environment

Ionizing radiation at high altitudes above the Earth adversely affects electronic systems in various ways. For these reasons, high-density, SRAM-based FPGA (field programmable gate array) systems have historically been unsuitable for use in space due to their higher susceptibility to radiation-induced soft error upsets (SEUs). However, there are a number of reasons for pursuing the deployment of adaptive FPGA-based designs in spacecraft systems and satellites. Frequently mission requirements change and FPGA systems are a mutable low-cost electronic fabric capable of adjusting to new design constraints after a system is initially released. Moreover, an adaptive FPGA design can attenuate the amount of fault tolerance in the system to the specific levels of radiation and the amount of available power, resources, and performance. Previously, the Triple3 Redundant Space Systems (T3RSS) approach demonstrated the use of partial reconfiguration of FPGA logic to ensure fault tolerance in FPGA-based space systems. This paper explores the issues germane to developing a reliable, high- performance memory system for FPGA architectures that seamlessly withstands both radiation-induced SEUs and permanent failures in space system hardware components.
Effect of Contrast on the Quality of 3D Visual Perception

—There are several different factors that affect the perceived quality of 3D content. Our objective in this paper is to study how the change of contrast between the objects of interest and the background in a scene will affect the overall 3D visual perception. For this study, we captured outdoor and indoor scenes in 3D format. For each scene, the brightness of the background was consistent and the object’s brightness was changing using an external light source and/or a reflector disk. Subjective evaluations were performed, with the subjects being asked to rate the 3D perceptual quality of each sequence. The results showed that the Weber contrast between objects of interest and background should be within the range of -0.35 to 0.55 to provide viewers with high quality of 3D experience.
Intent-Aware Diversification using Item-Based SubProfiles

In many approaches to recommendation diversification, a recommender scores items for relevance and then re-ranks them to balance relevance with diversity. In intent-aware diversification, diversity is formulated in terms of coverage of aspects, where aspects are either explicit such as movie genres or implicit such as the latent factors found during matrix factorization. Typically, the same set of aspects is used across all users. In this paper, we propose a form of personalized intent-aware diversification, which we call SPAD (SubProfile-Aware Diversification). The aspects we use in SPAD are subprofiles of the user’s profile. They are not defined in terms of explicit or implicit features. We compare SPAD to other forms of intent-aware diversification. We present empirical results in support of SPAD.
Pioglitazone (7·5 mg/day) added to flutamide–metformin in women with androgen excess: additional increments of visfatin and high molecular weight adiponectin

Background and aim Low‐dose pioglitazone (Pio), flutamide (Flu), metformin (Met) plus an oestro‐progestagen is a novel polytherapy lowering total and visceral adiposity, and reducing carotid intima media thickness (IMT) in hyperinsulinaemic women with androgen excess, without changing their body mass index (BMI). In a search for mediators of PioFluMet's actions, we measured serum levels of visfatin and high molecular weight (HMW) adiponectin.
Preclinical HER-2 Vaccines: From Rodent to Human HER-2

Effective prevention of human cancer with vaccines against viruses, such as HBV and HPV, raises the question whether also non-virus related tumors could be prevented with immunological means. Studies in HER-2-transgenic mice showed that powerful anti-HER-2 vaccines, could almost completely prevent the onset of mammary carcinoma. Protective immune responses were orchestrated by T cells and their cytokines, and effected by antibodies against HER-2 gene product p185. Analogous findings were reported in a variety of other cancer immunoprevention systems, thus leading to the definition of oncoantigens, optimal target antigens that are causally involved in carcinogenesis and cancer progression. Prophylactic HER-2 vaccines were also effective in preventing metastasis outgrowth, indicating that concepts and approaches developed for cancer immunoprevention could prove fruitful in cancer immunotherapy as well. The availability of cancer-prone mice carrying a human HER-2 transgene is now fostering the design of novel vaccines against human p185. A further bridge toward human cancer was recently provided by novel immunodeficient models, like Rag2−/−;Il2rg−/− mice, which are permissive for metastatic spread of human HER-2+ cancer cells and can be engrafted with a functional human immune system, allowing for the first time the study of vaccines against oncoantigens to elicit human immune responses against human cancer cells in vivo.
Taking Cognitive Task Analysis into the Field: Bridging the Gap from Research to Application

Cognitive methods of task analysis have been used for training development. Although quite promising, these methods are generally time consuming and labor-intensive, and require considerable expertise. This has precluded their full use in field training situations. Economical, practical and user-friendly methods are needed which can be integrated easily with current approaches. This symposium paper discusses the potential of cognitive task analysis as well as the practicality problem. Of particular concern is how cognitive methods can receive widespread application among training practitioners — how to transition theory and research in cognitive task analysis into mainstream training development programs.
Social, Emotional, and Behavioral Functioning of Children With Cancer

Objective. It was hypothesized that children with cancer would have more social problems and difficulties with emotional well-being than case control, same race/gender, similarly aged classmates. Study Design. Using a case controlled design, children with any type of cancer requiring chemotherapy except brain tumors (n = 76), currently receiving chemotherapy, ages 8 to 15, were compared with case control classroom peers (n = 76). Peer relationships, emotional well-being, and behavior were evaluated based on peer, teacher, parent, and self-report, and were compared using analysis of variance and structural equation modeling. Results. Relative to case controls, children with cancer were perceived by teachers as being more sociable; by teachers and peers as being less aggressive; and by peers as having greater social acceptance. Measures of depression, anxiety, loneliness, and self-concept showed no significant differences, except children with cancer reported significantly lower satisfaction with current athletic competence. There were also no significant differences in mother or father perceptions of behavioral problems, emotional well-being, or social functioning. Scores on all standardized measures were in the normal range for both groups. Comparisons of the correlation matrices of children with cancer and to the correlation matrix of the comparison children using structural equation modeling suggested they were not significantly different. Conclusions. Children with cancer currently receiving chemotherapy were remarkably similar to case controls on measures of emotional well-being and better on several dimensions of social functioning. These findings are not supportive of disability/stress models of childhood chronic illness and suggest considerable psychologic hardiness.
IEEE 802.11p modeling in NS-2

In an effort to develop a simulation framework for evaluating the performance of wireless access technologies for vehicular networks, the authors have studied the internal structure of the simulator, NS-2, as well as the draft wireless technology IEEE 802.11p. This intended framework aims at replicating, as far as possible, the access technology characteristics in the simulator and with the help of realistic scenarios intends to give an objective view of the performance of applications destined for intelligent transport systems. The framework is first designed to meet the requirements set for vehicle to infrastructure communications, with a view of later extending it to vehicle to vehicle communications for vehicular ad hoc networks.
The Impact of Operations Tempo on Turnover Intentions of Army Personnel

Previous research has found inconsistent links between operations tempo (OPTEMPO) and turnover in military personnel. This study addressed these inconsistent findings by including different operational definitions of retention, assessing whether the relation between OPTEMPO and turnover is curvilinear, and examining the impact of subjective perceptions of OPTEMPO on turnover. U.S. soldiers stationed in Europe were surveyed (N = 288) and interviewed (n = 177). Career intentions closely matched actual retention behavior as measured in archival records. Both perceptions of role overload related to OPTEMPO and workload measures of OPTEMPO were linked with career decision. Role overload related to work hours was associated with turnover, whereas a workload measure was not. Number of temporary duty (TDY) days was found to be curvilinear in relation to retention. Qualitative data identified similar reasons for turnover and retention across rank groups, but the way in which these reasons were processed differed by rank. Future research needs to consider rank, work context, definitions, and perceptions of OPTEMPO, as well as the influence of TDY days on turnover decisions.
Lack of protein‐tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomy

To investigate the role(s) of protein‐tyrosine sulfation in the retina, we examined retinal function and structure in mice lacking tyrosylprotein sulfotransferases (TPST) 1 and 2. Tpst double knockout (DKO; Tpst1−/−/Tpst2 −/−) retinas had drastically reduced electroretinographic responses, although their photoreceptors exhibited normal responses in single cell recordings. These retinas appeared normal histologically; however, the rod photoreceptors had ultrastructurally abnormal outer segments, with membrane evulsions into the extracellular space, irregular disc membrane spacing and expanded intradiscal space. Photoreceptor synaptic terminals were disorganized in Tpst DKO retinas, but established ultrastructurally normal synapses, as did bipolar and amacrine cells; however, the morphology and organization of neuronal processes in the inner retina were abnormal. These results indicate that protein‐tyrosine sulfation is essential for proper outer segment morphogenesis and synaptic function, but is not critical for overall retinal structure or synapse formation, and may serve broader functions in neuronal development and maintenance.
Synchronicity and analysis: Jung and after

Although he was a psychiatrist and psychotherapist, C.G. Jung (1875–1961) did not extensively present his novel concept of synchronicity (meaningful acausal connection) in terms of clinical observations and reflections. It remained for subsequent analysts to follow Jung's pioneering work with more clinically focused discussions. In order to take stock of some of the main trends within this work, this paper reviews, first, the examples of synchronicity and related comments that Jung does give in association with clinical contexts; and, second, a selection of mostly clinical papers that discuss the relationship between synchronicity and analysis, written throughout the period between the 1950s, when Jung's essays on synchronicity appeared, and the present. The review of the later clinical discussions focuses on questions of how frequently synchronicities occur in analysis, what dynamics of the psyche are principally involved in synchronicity, what are the clinical value and uses of synchronicity, and what is the relationship between clinical and theoretical reflections on synchronicity.