Miracle-dz/UniFAR-FTUs huggingface dataset:
On Spiro and polyphenyl hexagonal chains with respect to the number of BC-subtrees

ABSTRACT Topological indices of graphs have been vigorously studied. A novel structure-based index, the number of BC-subtrees (subtrees with at least two vertices satisfying that the distance between any two leaves is even), has received attention in recent years. In this paper we investigate this index on spiro and polyphenyl hexagonal chains, which are molecular graphs of a class of unbranched multispiro molecules and polycyclic aromatic hydrocarbons in organic chemistry. We first present the generating functions, recurrences, and explicit formulas for computing this index of spiro and polyphenyl hexagonal chains. Then, we determine the extremal values and characterize the extremal graphs with respect to the number of BC-subtrees among all spiro and polyphenyl hexagonal chains with n hexagons, respectively. Lastly, we analyse the BC-subtree density of these two hexagonal chains. These results provide a new perspective on exploring the structural properties of spiro and polyphenyl hexagonal chains.
Ambidexterity and Paradexterity: A typology of IT Governance contradictions

The theoretical construct of organizational ambidexterity addresses how organizations balance managerial contradictions such as exploitation and exploration or efficiency and flexibility. The underlying argument is that management should involve not a trade-off between two states, but simultaneous handling of contradictions. This paper expands the theory of organizational ambidexterity through introducing a typology of contradictions in the form of dichotomies and dualities within a particular management focus, i.e. IT Governance. The paper utilizes a previous study of IT Governance practice at two large, public universities to propose a typology and the concept of paradexterity. Through this, the paper seeks to add new knowledge to the fields of both organizational ambidexterity and IT Governance.
Treatment of refractory, symptomatic, hepatitis C virus related mixed cryoglobulinemia with ribavirin and interferon-alpha.

OBJECTIVE To assess the benefit of interferon-alpha/ribavirin combination therapy in hepatitis C virus (HCV) infected patients with symptomatic mixed cryoglobulinemia (MC) who failed to respond to treatment with interferon-alpha (IFN-alpha). METHODS Nine patients (mean age 57 +/- 14 yrs) with type II symptomatic MC who failed to respond to IFN-alpha monotherapy were re-treated with combination treatment of IFN-alpha 3 times weekly and ribavirin 15 mg/kg daily for 6 months. Five of 9 patients had previously received additional treatment during IFN-alpha monotherapy. Clinical and laboratory evaluations (including cryocrit level) were performed weekly for the first month and monthly thereafter. RESULTS Baseline mean alanine aminotransferase (ALT) and cryocrit levels were 119 +/- 97 IU/l and 7.9% +/- 10%, respectively. All patients were HCV-RNA positive and 5 had cirrhosis. At the end of therapy, mean ALT level was 84 +/- 79 IU/l (p = 0.02), while normal ALT levels were observed in 4 of 9 patients (44%). However, complete virological response was achieved in only 2 patients (22%). Cryoglobulin became undetectable within 6 weeks of therapy in 7 patients (78%) and decreased significantly in 2 others (p = 0.008). A substantial improvement in MC related symptoms (arthralgia/arthritis, proteinuria, skin vasculitis) was achieved in all patients within 10 weeks of combination therapy, although polyneuropathy related symptoms were relatively resistant to treatment. CONCLUSION Symptomatic, refractory HCV related MC should be considered as an indication for combination therapy with IFN-alpha and ribavirin. Improvement in MC related symptoms can be achieved even without complete biochemical or virological response.
Real time simulation of solar photovoltaic module using labview data acquisition card

The net power generated by solar photovoltaic (PV) module and the characteristics of its module depends on irradiance and temperature. This paper presents an analysis of the Solar PV module on the basis of variation in the characteristics under different temperature and irradiance using simulation tool. The base of study is mathematical modelling of the PV module using Labview. The process of designing and analysing has been carried out in two ways- one is the offline mode and other one is the real time simulation using the DAQ card. A real time input controlled by RPS is supplied to DAQ, creating an interface between labview and itself resulting into real time variation in characteristics. The results obtained from both the modes are similar which were obtained using the datasheet of the existing PV module present in the market.
VEGF coordinates interaction of pericytes and endothelial cells during vasculogenesis and experimental angiogenesis

Biological activities of vascular endothelial growth factor (VEGF) have been studied extensively in endothelial cells (ECs), but few data are available regarding its effects on pericytes. In murine embryoid body cultures, VEGF‐induced expression of desmin and α‐smooth muscle actin (α‐SMA) in CD‐31+ cells. The number of CD‐31+/desmin+ vascular chords increased with VEGF treatment time and peaked during a differentiation window between 6 and 9 days after plating. In vivo, VEGF‐induced elongation and migration of desmin‐positive pericytes and coverage of angiogenic capillaries, as revealed by analysis of Sambucus nigra lectin‐stained vascular beds of the chick chorioallantoic membrane. VEGF also caused significant decrease of intercapillary spaces, an indicator for intussusceptive vascular growth. These VEGF‐mediated effects point at a more intricate interaction between ECs and pericytes cells than previously demonstrated and suggest that pericytes may be derived from EC progenitors in vitro and not only stabilize capillaries but also participate in vascular remodeling in vivo. Developmental Dynamics 230:23–33, 2004. © 2004 Wiley‐Liss, Inc.
An implementable multi-calibration strategy to address real driving emissions of CI engines

In the last years emissions related to transportation have been in the focus of various legislation changes. The soon to be introduced Worldwide Harmonized Light-Duty Vehicles Test Procedure (WLTP) is one example for that. However, as shown by recent studies a substantial, often overlooked, factor is the driver itself and fixed procedures for testing within the legislation will not help in suppressing this influence. Classical calibration based engine control does not allow to counteract the drivers behavior or account for varying demands. Against this background we propose an engine control strategy based on multiple calibrations, where the selection of a calibration is the degree of freedom that can be used to counteract external influences. The calibration selection problem is mathematically formulated as a Boolean Linear Program (BLP) and an implementable approximate solution, which utilizes route specific information, is introduced. The method and its assumptions are validated by applying it in an experimental setup based on real road data and an engine testbed. The results show that the method is able to select a calibration in a sensible way and that the approximations lead to small constraint violations only.
Looking back: forward looking

Abstract GigaScience is now 5 years old, having been launched at the 2012 Intelligent Systems for Molecular Biology conference. Anyone who has attended what is the largest computational biology conference since then has had the opportunity to join us for each birthday celebration—and receive 1 of our fun T-shirts as a party prize. Since launching, we have pushed our agenda of openness, transparency, reproducibility, and reusability. Here, we look back at our first 5 years and what we have done to forward our open science goals in scientific publishing. Our mainstay has been to create a process that allows the availability and publication of as many “research objects” as possible to create a more complete way of communicating how the research process is done.
Hierarchical sulfur-impregnated hydrogenated TiO2 mesoporous spheres comprising anatase nanosheets with highly exposed (001) facets for advanced Li-S batteries

In this contribution, we purposefully designed hierarchical hydrogenated TiO2 spheres (HTSs) constructed from ultrathin anatase nanosheets with highly exposed (001) facets, and further utilized them as an efficient encapsulated host of sulfur species for advanced Li-S batteries (LSBs). Strikingly, the as-fabricated hybrid S/HTSs cathode exhibited high Coulombic efficiency (>94%), exceptional long cycling performance (capacity decay of ∼0.399% per cycle at 0.5 C), and large reversible discharge capacity (∼579 mAh g−1 at 2.0 C) at high C rates, benefiting from better electronic conductivity, smaller charge transfer resistance and strong chemical bonding between S n 2 − ? > and the reduced (001) facets of HTSs, according to experimental measurements and systematical theoretical calculations. More significantly, our in-depth insights into the mechanism involved in the hybrid S/HTSs could efficiently guide future design, optimization and synthesis of other metal oxide-based matrixes with specific exposed crystal facets for next-generation advanced LSBs.
A Low-Cost Attitude Determination and Control System for the UYS-1 nanosatellite

This paper considers the development of a Low-Cost Attitude Determination and Control Subsystem (LCADCS) for the first Ukrainian University Nanosatellite, UYS-1. For the attitude determination part, an attitude determination framework is implemented to combine all available data at each time sample using a modified Unscented Kalman Filter, based on the Unscented Quaternion Estimator (USQUE). For the attitude control part, the subsystem should rely only on magnetic actuation with magnetorquers operating in a relay mode. A proposed control strategy is presented. The choice of hardware and algorithms is addressed observing the LCADCS requirements, theoretical and practical considerations, ease of implementation, and time and cost budgets inherent to small-satellite projects. The validity and performance of the general proposed systems are evaluated using computer simulations.
The evaluation of violent thinking in adult offenders and non-offenders using the Maudsley Violence Questionnaire.

BACKGROUND The Maudsley Violence Questionnaire (MVQ) was designed to measure explicit rules and beliefs associated with violence. Previous studies with young people and offenders with mental disorder found the MVQ to be a valid and reliable measure of violent thinking. AIMS This study explores the use of the MVQ with a 'normal' (non-offender) population and an offender population without mental illness in order to evaluate how the MVQ's subscales related to violence within these groups. METHOD The MVQ was given to 78 adult male participants along with a measure of self-reported violence; demographic information and criminal history were also recorded. Thirty-five of the participants were convicted adult male offenders resident of an adult male closed prison in South Wales; 43 were volunteers from the staff group in the same prison. The MVQ factors were compared with self-reported violence and with officially recorded violent convictions. RESULTS Although both subscales of the MVQ related to self-reported violence, 'Machismo' showed a stronger relationship to both self-reported and officially recorded violence. CONCLUSIONS Violent thinking, specifically beliefs measured by the Machismo subscale of the MVQ, was robustly associated with self-reported and officially recorded violence in this study with offender and non-offender adults. IMPLICATIONS The MVQ is a valid and feasible measure for use with adult populations. Violent thinking (specifically Machismo thinking styles) should be included in the assessments of violent offenders. Work on violent thinking and reducing 'macho' thinking could be a useful adjunct to anger management work with violent offenders.
Mathematical modeling of boundary conditions for laser‐molecule time‐dependent Schrödinger equations and some aspects of their numerical computation—One‐dimensional case

This article deals with boundary conditions for time‐dependent Schrödinger equations for molecules excited by intense and ultrashort electric fields. On the basis of Volkov wavefunctions, we propose an original boundary condition design that allows to reduce spurious reflections at the domain boundary and allows to take at least partially, plasma effects into account. © 2008 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2009
Multi-linear polarization reconfigurable center-fed circular patch antenna with shorting posts

In this paper, a novel multi-linear polarization reconfigurable antenna with shorting posts, which can achieve four linear polarizations (0°, 45°, 90°, 135°), has been proposed. By switching the diodes between two groups of shorting posts, four linear polarizations can be realized. The dimensions of the proposed antenna are about 0. 56λ× 0. 56λ× 0. 07λ at 2.4 GHz. The measured results agree well with the simulated ones.
Decoupling of Multiple Coupled Photonic Crystal Waveguides

Decoupling of multiple coupled photonic crystal waveguides (M-CPCWs) is investigated based on the self-imaging principle. We choose the three-, four-, and eight-CPCWs as typical structures to discuss the general characteristics of the M-CPCWs. It is found that around the frequency where the multiple guided modes are almost degenerate, the power transfer in the M-CPCWs is eliminated for any entrance. The frequency region for decoupling is insensitive to the number of coupled waveguides with the extinction ratios higher than -15 dB. The decoupling of the M-CPCWs exhibit many advantages and may have practical applications in photonic integrated circuits.
Characterization and comparison of Australian human spotted fever group rickettsiae

The microbiological and molecular characteristics of the rickettsiae isolated from humans with Queensland tick typhus (QTT) caused by Rickettsia australis and the recently described Flinders Island spotted fever (FISF) were compared. Clinically and serologically, the diseases are similar. Cell culture reveals differences in the plaque-forming abilities of the isolates. Characterization of the gene encoding the genus-specific 17-kDa antigen of R. australis revealed a unique nucleotide sequence unlike those of the FISF isolate and Rickettsia rickettsii. Southern blot analysis of rickettsial DNA from the isolates with a 17-kDa-antigen gene probe revealed the presence of this gene in all isolates but no difference in banding patterns. When a probe for the rRNA genes was used, clear differences in banding patterns of isolates from patients with QTT and FISF were revealed. Thus, the rickettsiae isolated from patients with FISF differ from those from patients with QTT and may represent a new rickettsial species.
Comparison of early postoperative functional levels following total hip replacement using minimally invasive versus standard incisions. A prospective randomized blinded trial

Objective: To compare the results of single-incision minimally invasive total hip replacement (≤ 10 cm) to standard-incision (16 cm) total hip replacement in the early postoperative period with respect to functional and mobilizing ability (transfers, mobilizing, walking and stair assessment). Setting: Orthopaedic wards of a regional orthopaedic centre. Subjects: Two hundred and nineteen total hip replacement patients were tested between December 2003 and June 2004. Interventions: Patients were randomized to either total hip replacement through a minimally invasive (≤ 10 cm) or standard incision (16 cm). A single surgeon performed all procedures using the same type of component fixation. Postoperative physiotherapy assessment and treatment was standardized. Analgesia was also standardized. All patients, physiotherapy staff and assessors were blinded to the incision used. Main outcome measures: Patients were tested two days post operatively and were assessed for the following activities: transfer from supine to sit, transfer from sitting to standing, mobilizing, ascending and descending stairs and weight-bearing. Results: The shorter incision offered no significant improvement in patient ability in relation to transfer from lying to sitting, transfer from sitting to standing, mobilizing or weight-bearing. Ascending/descending stairs gave a total time for the minimal incision of 38.7 s against 40.8 s for a standard incision. There was no difference in walking velocity between the standard incision and minimal incision groups two days post operatively (minimal incision = 0.26 m/s versus standard incision = 0.26 m/s) or six weeks post operatively (minimal incision = 0.90 m/s versus standard incision = 0.93 m/s). There was no difference between groups with respect to walking aids at six-week review. The mean length of stay for the minimally invasive approach was 3.65 days (SD 2.04) against 3.68 days (SD 2.45) for the standard approach. This was not significantly different. Conclusion: Total hip replacement performed through a minimally invasive incision of ≤ 10 cm compared with a standard incision of 16 cm offers no significant benefit in terms of the rate or ability of patients to mobilize and perform functional tasks necessary for safe discharge.
Targeting c-Myc, Ras and IGF Cascade to Treat Cancer and Vascular Disorders

Cancer and vascular diseases remain the predominant causes of morbidity and mortality inindustrialized countries worldwide. The course of atherosclerosis with initiation, progression, andcomplication parallels the three stages of carcinogenesis with induction, growth, and invasion of tissue andneoangiogenesis. Within this framework, the oncogene c-Myc and growth factors pathways are acquiringincreasing importance. Insulin-like growth factor-1 (IGF-1) pathway emerges among them for its versatilepleiotropic actions. A number of genes that permit extensive communication between IGF-1-AKT, p53, andmammalian target of rapamycin (mTOR) pathways have been identified. In turn these pathways lead to p53transcriptional program, the forkhead transcriptional programs, autophagy, and translational controls, whichdetermine cell growth or arrest, cell survival or death. The increased understanding of the extensivecommunication and coordination between all these pathways may enable to targeting these events and toprevent neoplastic and vascular diseases. Great effort has been focused on the development of new agentsdesigned to target various steps of c-Myc, Ras, and IGF cascade. However, what have we recently learnedabout their safety and effectiveness? Here, we review the very recent advances in the identification of novelinhibitors as well as antisense oligonuleotides (ASOs) and siRNA that are proving their usefulness inongoing clinical trials both in therms of toxicity and specificity.
Um modelo de risco proporcional dependente do tempo

A analise de sobrevivencia tem por objetivo estudar dados de experimento em que a variavel resposta e o tempo ate a ocorrencia de um evento de interesse. Varios autores tem preferido modelar dados de sobrevivencia na presenca de covariaveis por meio da funcao de risco, fato este relacionado a sua interpretacao. Ela descreve como a probabilidade instantânea de falha se modifca com o passar do tempo. Nesse contexto, um dos modelos mais utilizados e o modelo de Cox (Cox, 1972), onde a suposicao basica para o seu uso e que as taxas de falhas sejam proporcionais. O modelo de riscos proporcionais de Cox e bastante flexivel e extensivamente usado em analise de sobrevivencia. Ele pode ser facilmente estendido para incorporar, por exemplo, o efeito de covariaveis dependentes do tempo. Neste estudo, propoe-se um modelo de risco proporcional, que incorpora um parâmetro dependente do tempo, denominado modelo de risco proporcional dependente do tempo. Uma analise classica baseada nas propriedades assintoticas dos estimadores de maxima verossimilhanca dos parâmetros envolvidos e desenvolvida, bem como um estudo de simulacao via tecnicas de reamostragem para estimacao intervalar e testes de hipoteses dos parâmetros do modelo. E estudado o custo de estimar o efeito da covariavel quando o parâmetro que mede o efeito do tempo e considerado na modelagem. E, finalizando, apresentamos uma abordagem do ponto de vista Bayesiano.
Identification of Nck Interacting Proteins in Vascular Smooth Muscle Cells

The adaptor molecule Nck has been demonstrated to mediate Angiotensin II (AngII)‐induced stimulation of p21‐activated kinase (PAK) and c‐Jun NH2‐terminal kinase (JNK) in vascular smooth muscle cells (VSMC). We have previously demonstrated, that immunoprecipitation of Nck from VSMC stimulated by AngII yielded an unidentified 100 kD phosphotyrosine (pTyr) protein. The present study was aimed at identifying the Nck‐associated 100 kD pTyr protein in VSMC. Several candidate proteins of appropriate size, that had been shown previously either to bind to Nck or had been implicated in signal transduction pathways leading to activation of PAK or JNK were tested for association with Nck in VSMC. The first candidate protein we tested was Git1, which did not bind to Nck in VSMC upon stimulation by AngII. However, we identified dynamin as a 100 kD protein that was bound to Nck in VSCM via interaction with the third Nck–SH3 domain. However, dynamin was not tyrosine phosphorylated by AngII treatment and seemed to be distinct from the 100 kD phosphotyrosine protein that was found in Nck immunoprecipitates. Future work will now have to identify the Nck‐associated 100 kD pTyr protein and functional studies will have to address its role in AngII signaling.
Extreme fear of being laughed at: components of gelotophobia

The present study investigated individuals with slight, marked and extreme fear of being laughed at (gelotophobia) (Ruch and Proyer 2008a). Altogether 640 individuals filled in the GELOPH (Ruch and Proyer 2008b) online and 228 filled in a paper and pencil version. In both samples principal components analyses of the 15 items were computed for subgroups of individuals exceeding the cut-off point for slight gelotophobia (i.e., 2.5). All solutions between one and five factors were examined but a three-factor-solution seemed most preferable. These positively correlated components were interpreted as coping with derision (by control, withdrawal, internalizing), disproportionate negative responses to being laughed at, and paranoid sensitivity to anticipated ridicule. The latter two are seen specific to gelotophobia while the former might be shared with social anxiety in general. In the hierarchical factor analysis the more unspecific coping factor did split up further into three factors of control, withdrawal, and internalizing, while the two gelotophobia-specific factors stayed stable between the three- and five-factor solutions. These three factors yielded different correlational patterns. Coping with ridicule was higher among females and among the older while there were no differences for the other two factors. Furthermore, people reporting having been bullied were higher in defensive coping with ridicule and had stronger disproportionate negative responses to being laughed at than those who were not bullied. Results are discussed within a framework for future studies of individuals with higher levels of this fear. In particular, the computation of subscales is recommended when the focus lies on the extreme scorers.
Crawling English-Japanese person-name transliterations from the web

Automatic compilation of lexicon is a dream of lexicon compilers as well as lexicon users. This paper proposes a system that crawls English-Japanese person-name transliterations from the Web, which works a back-end collector for automatic compilation of bilingual person-name lexicon. Our crawler collected 561K transliterations in five months. From them, an English-Japanese person-name lexicon with 406K entries has been compiled by an automatic post processing. This lexicon is much larger than other similar resources including English-Japanese lexicon of HeiNER obtained from Wikipedia.