Miracle-dz/UniFAR-FTUs huggingface dataset:
The Multi-KH Domain Protein of Saccharomyces cerevisiae Scp160p Contributes to the Regulation of Telomeric Silencing*

Multi-KH domain proteins are highly evolutionarily conserved proteins that associate to polyribosomes and participate in RNA metabolism. Recent evidence indicates that multi-KH domain proteins also contribute to the structural organization of heterochromatin both in mammals and Drosophila. Here, we show that the multi-KH domain protein of Saccharomyces cerevisiae, Scp160p, contributes to silencing at telomeres and at the mating-type locus, but not to ribosomal silencing. The contribution of Scp160p to silencing is independent of its binding to the ribosome as deletion of the last two KH domains, which mediate ribosomal binding, has no effect on silencing. Disruption of SCP160 increases cell ploidy but this effect is also independent of the contribution of Scp160p to telomeric silencing as strong relief of silencing is observed in Δscp160 cells with normal ploidy and, vice versa, Δscp160 cells with highly increased ploidy show no significant silencing defects. The TPE phenotype of Δscp160 cells associates to a decreased Sir3p deposition at telomeres and, in good agreement, silencing is rescued by SIR3 overexpression and in a Δrif1Δrif2 mutant. Scp160p shows a distinct perinuclear localization that is independent of its ability to bind ribosomes. Moreover, telomere clustering at the nuclear envelope is perturbed in Δscp160 cells and disruption of the histone deacetylase RPD3, which is known to improve telomere clustering, rescues telomeric silencing in Δscp160 cells. These results are discussed in the context of a model in which Scp160p contributes to silencing by helping telomere clustering.
An Empirical Study on the Impact of the Logistics Industry to Economic Structure

At present,China has entered a critical period of economic restructuring.In the future,the direction of China's economic development is to change the mode of economic development,promote economic structural transformation.Taking Xi'an as a case,the paper uses correlation analysis,the contribution rate model,location quotient and other multiplier method to analyze how the logistics industry to promote the optimization of economic structure.The results show that Xi'an is better than the national average in optimizing the economic structure,but it is still not play a good role in optimizing the economic structure.
Inhibition of Na+‐H+ exchanger‐3 interferes with apical receptor‐mediated endocytosis via vesicle fusion

1 Receptor‐mediated endocytosis in epithelial cells is a crucial mechanism for transport of macromolecules and regulation of cell‐surface protein expression. Na+‐H+ exchanger type 3 (NHE3) has been shown to cycle between the apical plasma membrane and the early endosomal compartment and to interfere with endocytosis. 2 In the present study we investigated in detail the NHE3‐dependent step of apical endocytosis in an epithelial cell line (opossum kidney cells). 3 Inhibition of NHE3 led to a rapid dose‐dependent inhibition of apical albumin endocytosis but did not affect basolateral transferrin endocytosis. Re‐exocytosis of albumin was not increased by NHE3 inhibition. 4 NHE3 dependency of albumin endocytosis was still observed at 20 °C or when microtubules had been disrupted. This was not the case for inhibition of vacuolar H+‐ATPase. 5 NHE3 inhibition rapidly blocked internalisation of pre‐bound albumin and attenuated degradation of internalised albumin without changing general protein degradation. 6 Furthermore, NHE3 inhibition reduced the rate of endocytic vesicle fusion significantly. 7 In summary, our data indicate that NHE3 is important for the early phase of the apical endocytic pathway, located between the plasma membrane and early endosomes, at least in part due to its involvement in endocytic vesicle fusion.
The effectiveness of cognitive behavioral group therapy in treating bipolar disorder: a randomized controlled study.

OBJECTIVE Recent studies suggest that, when combined with pharmacotherapy, structured psychotherapy may modify the course of bipolar disorder. However, there are few studies that have examined the effects of cognitive behavioral group therapy on the course of this disorder. The aim of the present study was to evaluate the effectiveness of 14 sessions of cognitive behavioral group therapy, combined with pharmacotherapy, on the treatment of patients with bipolar disorder, and to compare our results against those from the use of pharmacotherapy alone. METHOD Forty-one patients with bipolar I and II disorder participated in the study and were randomly allocated to one of two treatment groups; thirty-seven patients remained in the study until its completion. Mood and anxiety symptoms were measured in all subjects. Statistical analysis was used to investigate if the groups differed with respect to demographic characteristics and the scores recorded in the pre- and post-treatment stages, as well as during treatment (intra/inter groups). RESULTS Patients showed statistically similar population characteristics. The association of cognitive behavioral group therapy and pharmacological treatment proved to be effective. Patients who had undergone cognitive behavioral group therapy presented fewer symptoms of mania, depression and anxiety, as well as fewer and shorter mood change episodes. CONCLUSION Cognitive behavioral group therapy sessions substantially contributed to the improvement of depression symptoms.
A New Genus and Species of Gyrodactylid (Monogenea) From Silver Hake, Merluccius Bilinearis, in the Bay of Fundy, New Brunswick, Canada

Abstract Gyrocerviceanseris passamaquoddyensis n. gen., n. sp. is described from the gills of silver hake, Merluccius bilinearis, in Passamaquoddy Bay, southwestern New Brunswick, Canada. Diagnostic features include an oval haptor with asymmetrically distributed marginal hooks (3 pairs anterior, 5 pairs posterior) and a prominent muscular flange on the lateral margins, between the anterior and posterior groups of hooks. The hamuli are well developed, with a straight point, a short shaft, and an elongate, blade-like ventral root having a ventrally directed, gooseneck-shaped tip. The ventral bar is rectangular, with a small, hourglass-shaped posterior membrane. There is no dorsal bar. The marginal hook sickle is sharply curved, with a long fine point, an upturned toe, a small heel, and a straight handle. A partial DNA sequence from 18S rDNA was generated and found to be over 11% divergent from its closest matches in GenBank. However, it was less divergent (7.8%) from a previously unpublished sequence of Gyrodactylus emembranatus Malmberg, 1970, suggesting this species is its closest known relative. Interestingly, both species have almost identical marginal hook sickles and a male copulatory organ (MCO) with small spines in multiple arched rows. Gyrocerviceanseris n. gen. is the sixth genus of viviparous monogeneans to be described from marine and estuarine fishes of the northwestern Atlantic Ocean.
Chronic Fenfluramine Administration: Some Cerebral Effects

Human cerebral function was monitored electrophysiologically during sleep over a period of months before, during, and after the intake of fenfluramine, 40-120 mg/day. Effects included dose-related reduction of paradoxical sleep, increase of intra-sleep restlessness, and changes in E.E.G. slow-wave sleep. It is hypothesized that weight loss may be associated with increase of the last. Grinding of teeth (bruxism) also was noted. Long-term studies make it possible to demonstrate changing central effects with time, including tolerance phenomena. Withdrawal abnormalities are related to the time taken for the drug to be eliminated—in the present case reaching a maximum four days after withdrawal.
Workplace social capital and all-cause mortality: a prospective cohort study of 28,043 public-sector employees in Finland.

OBJECTIVES We examined the association between workplace social capital and all-cause mortality in a large occupational cohort from Finland. METHODS We linked responses of 28 043 participants to surveys in 2000 to 2002 and in 2004 to national mortality registers through 2009. We used repeated measurements of self- and coworker-assessed social capital. We carried out Cox proportional hazard and fixed-effects logistic regressions. RESULTS During the 5-year follow-up, 196 employees died. A 1-unit increase in the mean of repeat measurements of self-assessed workplace social capital (range 1-5) was associated with a 19% decrease in the risk of all-cause mortality (age- and gender-adjusted hazard ratio [HR] = 0.81; 95% confidence interval [CI] = 0.66, 0.99). The corresponding point estimate for the mean of coworker-assessed social capital was similar, although the association was less precisely estimated (age- and gender-adjusted HR = 0.77; 95% CI = 0.50, 1.20). In fixed-effects analysis, a 1-unit increase in self-assessed social capital across the 2 time points was associated with a lower mortality risk (odds ratio = 0.81; 95% CI = 0.55, 1.19). CONCLUSIONS Workplace social capital appears to be associated with lowered mortality in the working-aged population.
Effect of oral creatine supplementation on muscle [PCr] and short-term maximum power output.

Our purpose was to determine the effect of creatine supplementation on power output during a 30-s maximal cycling (Wingate) test. Nine males underwent 3 randomly ordered tests following ingestion of a creatine supplementation (CRE), placebo (PLA), and control (CON) CRE was ingested as creatine monohydrate (CrH2O) dissolved in a flavored drink (20g.d-1 for 3 d), while PLA consisted of the drink only. Tests were performed 14 d apart on a Monarch ergometer modified for immediate resistance loading. Needle biopsies were taken from the vastus lateralis at the end of each treatment period and before the exercise test. No difference was found between conditions for peak, mean 10-s, and mean 30-s power output, percent fatigue, or post-exercise blood lactate concentration. Similarly, no difference between conditions was observed for ATP, phosphocreatine (PCr), or total creatine (TCr); however, the TCr/ATP was higher in the CRE condition (P < 0.05) than in the CON and PLA conditions. Findings suggest that 3 d of oral Cr supplementation does not increase resting muscle PCr concentration and has no effect on performance during a single short-term maximal cycling task.
Transmission characteristics of circular waveguide with coaxial-to-circular waveguide transitions

The reflection and transmission characteristics of a circular waveguide with coaxial-to-circular waveguide transitions are evaluated using Galerkin's method of moments. Because of the axisymmetric structure as well as the assumption of a TEM-mode incident wave, which is an axisymmetric mode, the scattered waves from the structural discontinuities can be expressed as axisymmetric modes; therefore, the analysis can be considerably simplified. In addition, by making the most of the structural symmetry for both sides (ports), a further reduction in the calculation can be performed. The characteristics are calculated as a function of frequency, and reasonable and interesting results are obtained. The circumferential slot antenna in the circular waveguide as well as the nondestructive inspection of circumferential cracks and wall-thinning inside conductive pipes are promising candidates for this technique.
Effects of Endurance Training on Endocrine Response to Physical Exercise after 5 Days of Bed Rest in Healthy Male Subjects

Abstract: The study was designed to evaluate how a bout of endurance training (ET) influences the endocrine response after head‐down bed rest (HDBR). Eleven healthy males completed the study, which consisted of a 6‐wk ET followed by 5 days of −6° head‐down HDBR. Treadmill exercise at 80% of pretraining maximal aerobic capacity (VO2max) was performed before and after ET as well as after HDBR. ET increased VO2max by 13%. The response of norepinephrine was attenuated after ET and exaggerated after HDBR (P < 0.001). The differences in epinephrine responses were not statistically significant. The responses of cortisol and plasma renin activity (PRA) were unchanged after ET and were enhanced after HDBR (P < 0.001). The response of growth hormone after HDBR was reduced (P < 0.05). Only the change in cortisol response was associated with the increment of VO2max after ET (r= 0.68, P < 0.01). Endurance training failed to completely prevent changes in endocrine responses seen after HDBR. Improvement of physical fitness was associated with an enhancement of the cortisol response to exercise following the period of bed rest.
Digital Mammography : From Physical Performance Evaluation To Image Quality Analysis

Since the early 1990s digital X-ray detectors have been used extensively for medical imaging applications, such as Mammography, General Radiography, Computed Tomography, Tomosynthesis, Fluoroscopy, etc. The quality of a radiograph needs to be adequate to provide the required information for a given task. The primary physical parameters that affect image quality are spatial resolution, noise, and contrast. The Modulation Transfer Function (MTF) is the combination of contrast and resolution, the Noise Power Spectrum (NPS) combines the noise and resolution, and the Signal-to-Noise Ratio (SNR) expresses the ratio between signal and noise in large scale objects (i.e. at zero spatial frequency). The combination of SNR, MTF and NPS determines the Detective Quantum Efficiency (DQE) which represents the ability to visualize object details of a certain size and contrast. This study is using image simulation to estimate how the experimentally measured SNR, MTF and NPS of several digital X-ray detectors affect the mammographic image quality. The latter is measured in terms of Contrast-to-Noise Ratio (CNR) and Contrast-Detail (CD) analysis, using synthetic breast and CDMAM phantoms, respectively.
Allocation of water consumption in multipurpose reservoirs

The Intergovernmental Panel on Climate Change Special Report on Renewable Energy Sources represented a benchmark in the assessment of water consumption from electricity production. The numbers for hydropower ranged from very low to much larger than the other renewable technologies, partly explained by methodological problems. One of the methodological shortcomings identified was the lack of guidance on how to allocate the water consumption rates in multipurpose reservoirs. This paper is, according to the authors’ knowledge, the first attempt to evaluate, test and propose a methodology for the allocation of water consumption from such reservoirs. We tested four different allocation methods in four different cases, all serving three to five functions, including drinking water supply, irrigation, flood control, industrial water, ecological flow and power generation. Based on our case studies we consider volume allocation to be the most robust approach for allocating water consumption between functions in multipurpose reservoirs. The spatial boundaries of the analysis should follow the boundaries of the hydraulic system. We recommend that data should preferably be gathered from one source for all functions, to ensure a consistent calculation approach. We believe the findings are relevant for similar allocation problems, such as allocation of energy investments and green-house gas emissions from multipurpose reservoirs.
Manual Transmission Enhances Attention and Driving Performance of ADHD Adolescent Males

Objective: Inattention is a major contributor to driving mishaps and is especially problematic among adolescent drivers with ADHD, possibly contributing to their 2 to 4 times higher incidence of collisions. Manual transmission has been demonstrated to be associated with greater arousal. This study tests the hypotheses that manual transmission, compared to automatic transmission, would be associated with better attention and performance on a driving simulator. Method: Ten adolescent drivers with ADHD practice driving on the simulator in the manual and automatic mode. Employing a single-blind, cross-over design, participants drive the simulator at 19:30 and 22:30 hr for 30 min in both transmissions and rate their attention to driving. Results: Subjectively, participants report being more attentive while driving in manual transmission mode. Objectively, participants drive safer in the manual transmission mode. Conclusion: Although in need of replication, this pilot study suggests a behavioral intervention to improve driving performance among ADHD adolescents.
Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and meta-analysis

Background: There have been postmarketing reports of adverse cardiovascular events associated with the use of varenicline, a widely used smoking cessation drug. We conducted a systematic review and meta-analysis of randomized controlled trials to ascertain the serious adverse cardiovascular effects of varenicline compared with placebo among tobacco users. Methods: We searched MEDLINE, EMBASE, the Cochrane Database of Systematic Reviews, websites of regulatory authorities and registries of clinical trials, with no date or language restrictions, through September 2010 (updated March 2011) for published and unpublished studies. We selected double-blind randomized controlled trials of at least one week’s duration involving smokers or people who used smokeless tobacco that reported on cardiovascular events (ischemia, arrhythmia, congestive heart failure, sudden death or cardiovascular-related death) as serious adverse events asociated with the use of varenicline. Results: We analyzed data from 14 double-blind randomized controlled trials involving 8216 participants. The trials ranged in duration from 7 to 52 weeks. Varenicline was associated with a significantly increased risk of serious adverse cardiovascular events compared with placebo (1.06% [52/4908] in varenicline group v. 0.82% [27/3308] in placebo group; Peto odds ratio [OR] 1.72, 95% confidence interval [CI] 1.09–2.71; I2 = 0%). The results of various sensitivity analyses were consistent with those of the main analysis, and a funnel plot showed no publication bias. There were too few deaths to allow meaningful comparisons of mortality. Interpretation: Our meta-analysis raises safety concerns about the potential for an increased risk of serious adverse cardiovascular events associated with the use of varenicline among tobacco users.
Aerosol particulate matter in the Baltimore metropolitan area: Temporal variation over a six-year period

This study investigates the sources of fine particulate matter (aerodynamic diameter ≤2.5 μm; PM2.5) composition for the Baltimore, Maryland, metropolitan area, covering a 6-year period (2008–2013). Data obtained from the U.S. Environmental Protection Agency (EPA) Air Quality System (AQS) were used for the identification of eight chemical speciation clusters (factors), which, as a percentage of the average concentration, were identified as secondary sulfate (31.9%), secondary nitrate (14.3%), gasoline (17.4%), diesel (10.1%), soil (4.0%), biomass burning (11%), marine aerosol (4.1%), and industrial processing (7.2%). The results show predominant influence from vehicle emissions transiting major highways I-695 and I-95 located in the vicinity of the sampling site. Strong influence on PM2.5 mass from biomass burning was found in the first 2 years (2008–2009) due to particulate matter remnants from forest fire events in North Carolina and a strong contribution in 2013 that was due mainly to wood burning during winter. Sulfate, nitrate, soil, and marine aerosol fractions registered very low variability over the 6-year period analyzed. In addition, this study shows a significant reduction in particulate matter from industrial origins after a major industrial source in Baltimore shut down. The results obtained from Baltimore were compared with those from the Beltsville, Maryland, sampling station located 25 miles south of Baltimore for 2011 and 2012, where good agreement was found for most of the factors. Implications: This paper presents the first long-term aerosol speciation analysis in a Mid-Atlantic United States metropolitan area, which is essential for the air quality management agencies in order to revise regulations and reduce human exposure to adverse air quality conditions. The results suggest that although a declining trend in the overall PM2.5 was observed, no significant tendency was observed in the identified sources besides exceptional events such as the impact of wildfires on local air quality and downward contribution from industrial fraction of PM2.5 after the Steel Mill at Sparrows Point closure in 2012.
Effect of Forward Trunk Inclination on Joint Power Output in Vertical Jumping

It is commonly accepted that vertical jump performance is a good indicator of maximal joint power. Some studies, however, have indicated that knee joint power output in the vertical jump is limited due to forward trunk inclination early in the push-off. The aim of this experimental study was to investigate the effect of forward trunk inclination on joint power output in vertical jumping. A group of 20 male subjects performed maximal vertical countermovement jumps from stance while minimizing the contribution of arm swing by holding their hands on their hips (arms akimbo). They also performed maximal jumps while holding the trunk as upright as possible throughout the jump, still holding the arms akimbo. Jump height, joint kinematics (angles), and joint kinetics (torque, power) were calculated. Jump height of vertical jumps while holding the trunk upright was 10% less than in normal jumps. Hip joint power was decreased by 37% while knee joint power was increased by 13%. Ankle joint power did not change. These results demonstrated that maximal jump performance does not necessarily represent maximal power of each individual joint. The implication is that jump performance may well be a good representation of overall joint power; it is, however, not an accurate measure to evaluate maximal individual joint power as part of contemporary training and rehabilitation methods.
Association analysis of adenosine A1 receptor gene (ADORA1) polymorphisms with schizophrenia in a Japanese population

Objective The human adenosine A1 receptor gene (ADORA1) localizes to chromosome 1q32 is 76.8 kbp in length and contains six exons. ADORA1 is ubiquitously expressed in the central nervous system and clinical and pharmacological evidence suggest the involvement of adenosine neurotransmission in the pathogenesis of schizophrenia. Therefore, we investigated the contribution of genetic variations of ADORA1 to the pathophysiological mechanisms of Japanese schizophrenia patients. Methods We performed genetic analysis of 29 polymorphic markers in 200 schizophrenic patients and 210 healthy controls from the Kyushu region of Japan. In statistical analysis, we performed the univariate analysis with genotypes and allele frequencies, linkage disequilibrium (LD) analyses, multivariate analysis, haplotype analysis, and sliding window haplotype analysis. Results In univariate analysis, no statistical difference was shown, after Bonferroni correction. By LD analysis, however, we could not find any LD blocks. In haplotype analysis, a total of 359 haplotypes were estimated. In multivariate analysis, we found three statistically different markers. In sliding window haplotype analysis, there were four statistically different haplotypes. Conclusion This is the first study describing the involvement of ADORA1 polymorphisms in the pathophysiological mechanisms of schizophrenia in a Japanese population. These results corroborate our previous pharmacological and neurochemical studies in the rat that have suggested an association between ADORA1 neurotransmission and the schizophrenic effects of the N-methyl-D-aspartate receptor antagonist phencyclidine. Thus, ADORA1 polymorphisms may represent good candidate markers for schizophrenia research and ADORA1 may be involved in the pathophysiological mechanisms of schizophrenia in Japanese populations.