Miracle-dz/UniFAR-FTUs huggingface dataset:
A closed-form inverse kinematic modelling of a 7R anthropomorphic upper limb based on a joint parametrization

The problem of the redundancy control of 7R anthropomorphic arms is addressed by looking for an inverse kinematic model of the augmented wrist location. The classical notion of "arm angle" as a privileged additional scalar parameter is studied: its direct expression is given in the case of a zero-offset 7R anthropomorphic arm, but its inverse expression in closed-form appears to be too difficult to obtain. To overcome this difficulty we propose using a joint variable as a redundancy parameter and we show that the choice of the abduction arm angle allows the indirect, but efficient, control of the "arm angle". A simple and complete closed-form inverse kinematic model of a typical 7R anthropomorphic robot-arm can then be exhibited. Simulations show the relevance of the approach to controlling, in a simple way, both hand and elbow location
Circularly polarized patch antenna array for satellite communication in Ku band

This paper presents a patch antenna array for circular polarization (CP) operation. CP is produced by the truncated corner of a square patch loaded with a U-slot. The array consists of 3 layers. The bottom layer is a hollow metallic waveguide feed network to provide corporate feeding to 64 cavities through aperture coupling. The rectangular cavities constitute the middle layer. Each cavity then excites a 2×2 subarray on the top layer with each element fed by a coupling probe through a circular hole. Good impedance matching and CP radiation characteristic can be achieved by the 16×16 antenna array. The proposed antenna can be used in Ku band satellite communication.
Practice Guidelines for Perioperative Blood Transfusion and Adjuvant Therapies: An Updated Report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies

PRACTICE guidelines are systematically developed recommendations that assist the practitioner and patient in making decisions about health care. These recommendations may be adopted, modified, or rejected according to clinical needs and constraints. Practice guidelines are not intended as standards or absolute requirements. The use of practice guidelines cannot guarantee any specific outcome. Practice guidelines are subject to revision as warranted by the evolution of medical knowledge, technology, and practice. They provide basic recommendations that are supported by analysis of the current literature and by a synthesis of expert opinion, open forum commentary, and clinical feasibility data. This update includes data published since the “Practice Guidelines for Blood Component Therapy” were adopted by the American Society of Anesthesiologists (ASA) in 1995; it also includes data and recommendations for a wider range of techniques than was previously addressed. Methodology
Large-Eddy Simulation , Fuel Rod Vibration and Grid-to-Rod Fretting ✩

The grid-to-rod fretting (GTRF) problem in pressurized water reactors is a flow-induced vibration phenomenon that results in wear and failure of the cladding material on fuel rods. Grid-to-rod fretting is responsible for over 70% of the fuel leaks in pressurized water reactors in the U.S. The GTRFinduced wear process involves turbulent flow, mechanical vibration, tribology, and time-varying irradiated material properties in complex fuel assembly geometries. This paper presents a new approach for predicting GTRF induced fuel rod wear that uses high-resolution large-eddy simulation to drive nonlinear transient dynamics computations. The GTRF fluid-structure problem is separated into the simulation of the turbulent flow field in the complexgeometry fuel-rod bundles, calculation of statistics of the resulting fluctuating structural forces, and the nonlinear transient dynamics analysis of the fuel rod. Implicit large-eddy simulation is used to compute the time-dependent fluid forces downstream of a Westinghouse designed spacer-grid with mixing vanes: The turbulent flow simulation procedure is first validated using a 5×5 rod bundle configuration and comparing simulated and experimentallymeasured velocities immediately downstream of the mixing vanes. Next, ✩LA-UR-14-28497 ∗Corresponding author. Email addresses: christon@lanl.gov (Mark A. Christon), lur@westinghouse.com (Roger Lu), jbakosi@lanl.gov (Jozsef Bakosi), balu@lanl.gov (Balu Nadiga), karoutze@westinghouse.com (Zeses Karoutas), berndt@lanl.gov (Markus Berndt) Preprint submitted to Journal of Computational Physics April 13, 2016 highly-instrumented large-eddy simulations of the 3 × 3 rod bundle flow using a sequence of four meshes with increasing resolution is performed. The forces on the central fuel rod downstream of the mixing vanes are seen to fall in an asymptotic regime at the finer three resolutions, and this feature of the numerics is exploited to obtain the limiting values of the fuel rod forces using Richardson extrapolation. Furthermore, uncertainty in the fuel rod forces due to turbulent intermittency are estimated using time-series data from the one second turbulent computations. Finally, the simulated fluid dynamic forces on the fuel rod are used in nonlinear transient dynamics analyses of a full length fuel rod with spacer grids to obtain fuel rod acceleration, displacement and fuel rod wear. Robustness of the behavior of both the structural forces computed from the turbulent flow simulations and the results from the transient dynamics analyses highlight the progress made towards achieving a predictive simulation capability for the GTRF problem.
Is rectal indomethacin effective in preventing of post-endoscopic retrograde cholangiopancreatography pancreatitis?

AIM To investigate the effectiveness of rectally administered indomethacin in the prophylaxis of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and hyperamylasaemia in a multicentre study. METHODS A prospective, randomised, placebo-controlled multicentre study in five endoscopic units was conducted on 686 patients randomised to receive a suppository containing 100 mg indomethacin, or an inert placebo, 10-15 min before ERCP. Post-ERCP pancreatitis and hyperamylasaemia were evaluated 24 h following the procedure on the basis of clinical signs and laboratory parameters, and computed tomography/magnetic resonance imaging findings if required. RESULTS Twenty-one patients were excluded because of incompleteness of their data or because of protocol violation. The results of 665 investigations were evaluated: 347 in the indomethacin group and 318 in the placebo group. The distributions of the risk factors in the two groups did not differ significantly. Pancreatitis developed in 42 patients (6.3%): it was mild in 34 (5.1%) and severe in eight (1.2%) cases. Hyperamylaesemia occurred in 160 patients (24.1%). There was no significant difference between the indomethacin and placebo groups in the incidence of either post-ERCP pancreatitis (5.8% vs 6.9%) or hyperamylasaemia (23.3% vs 24.8%). Similarly, subgroup analysis did not reveal any significant differences between the two groups. CONCLUSION 100 mg rectal indomethacin administered before ERCP did not prove effective in preventing post-ERCP pancreatitis.
A Directed Labeled Graph Frequent Pattern Mining Algorithm Based on Minimum Code

Most of existing frequent subgraph mining algorithms are used to deal with undirected unlabeled marked graph. A few of them aim at directed graph or labeled graph. But in the real world ,a lot of connections have direction and label,so directed labeled graph mining is more meaningful. Now we are analyzing a financial network which can be modeled by a directed weighted graph. We are interested in the patterns which are frequent.The graph pattern means a uniform expression of graphs which has different marked nodes but same structure. In our application we consider direction and weight as part of the pattern. It’s different from subgraph because subgraph mining consider the labels of nodes. This paper proposes a new algorithm mSpan for directed labeled graph frequent pattern mining. Based on FP-growth, the algorithm gets a minimum edge code and an abstract node code sequence to indentify a directed graph pattern uniquely through minimum extension. It can solve the graph pattern isomorphic problem and the redundant extension problem. The experiment shows that mSpan can mine all frequent directed, labeled graph patterns.
The value of knowledge sharing: impact of tacit and explicit knowledge sharing on team performance of scientists

Knowledge sharing that takes place among team members is a process of great relevance that builds ties and relationships which in turn results in positive organizational and team outcomes. However, as it is not usually formally included in the job descriptions and is not a formal part of organizations’ and team activities, it is considered to be an organization citizenship behavior. Our paper emphasizes significance of tacit and explicit knowledge sharing to team performance in the context of scientific cooperation. A positive relationship between tacit knowledge sharing and explicit knowledge sharing with team performance was found using linear regression. Furthermore, high levels of knowledge sharing and team performance were identified among scientists. Keywords: Team performance, Knowledge sharing, Tacit knowledge, Explicit knowledge, Scientific cooperation
Character segmentation for Nastaleeq URDU OCR: A review

Urdu Nastaleeq is a highly cursive, context sensitive language, written diagonally from top right to bottom left that makes it difficult to segment the partial word or a compete word into characters. Further due to stacking of characters, the segmentation at the character level is hard to perform. Some researchers have performed the ligature level segmentation and have succeeded to a great extent, but the accuracy of segmentation is still less and needs to improved. In this paper, the methodology for segmentation of Urdu nastaleeq at the character level is presented. The various challenges encountered during segmentation have been discussed in detail.
Surface expression of a nonstructural antigen on influenza A virus-infected cells

Rabbit antiserum to the influenza A virus nonstructural protein, NS1, was used for indirect immunofluorescence studies of infected cells. Nonstructural antigens were detected on surfaces of P815 cells as early as 4 h after infection with A/WSN/40 virus. Adsorption of the serum with virion structural proteins did not affect the observed fluorescence, and a progressive increase in surface fluorescence at later times postinfection indicated that the surface antigen was newly synthesized during the replication cycle.
Resistance in Ureaplasma spp . and Mycoplasma hominis : Prevalence in 1 Bordeaux , France , from 1999 to 2002 and Description of Two tet ( M )-positive Isolates of 2 M . hominis Susceptible to Tetracyclines . 3

Tetracycline Resistance in Ureaplasma spp. and Mycoplasma hominis: Prevalence in 1 Bordeaux, France, from 1999 to 2002 and Description of Two tet(M)-positive Isolates of 2 M. hominis Susceptible to Tetracyclines. 3 S. Dégrange, H. Renaudin, A. Charron, C. Bébéar, and C. M. Bébéar*. 4 5 Laboratoire de Bactériologie EA 3671, Université Victor Segalen Bordeaux 2 and CHU de 6 Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. 7 8 9 10 *Corresponding author. 11 Mailing address: Laboratoire de Bactériologie EA 3671, Mycoplasma and chlamydiae 12 infections in humans, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 13 Bordeaux Cedex, France. Phone (33) 5.57. 57.16. 25. Fax (33) 5.56. 93.29. 40. Electronic mail 14 address: cecile.bebear@u-bordeaux2.fr 15 16 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00960-07 AAC Accepts, published online ahead of print on 19 November 2007
Asthma biomarkers: what constitutes a ‘gold standard’?

Many studies have assessed sputum eosinophil percentage as a phenotypic descriptor in asthma patients. Adjusting inhaled corticosteroid (ICS) dose based on sputum eosinophilia can lead to better clinical outcomes than using empirical clinical guidelines alone.1 ,2 While techniques for collecting and analysing sputum eosinophils are available in specialty clinics, sputum analysis remains time consuming, onerous to the patient, labour intensive and is not always successful, which precludes its broader clinical generalisability to primary care settings where most asthma patients are managed. Thus, there is a need for less invasive and more technically straightforward means of phenotyping asthma patients to enable therapeutic management along biological, rather than empirical, guidelines. In particular, accurate phenotyping of severe asthma patients refractory to ICS treatment has proven to be critical for demonstrating the efficacy of emerging experimental therapies that target specific inflammatory pathways.3 Sterk and colleagues compared three biomarkers, peripheral blood eosinophils, fractional exhaled nitric oxide (FeNO) and serum periostin levels, for assessing how reliably each reflects sputum eosinophilia in a cross-sectional study.4 They report that blood eosinophils performed favourably, with a receiver operating characteristic area under the curve of 0.89 in a test cohort and 0.85 in a replication cohort. Using a threshold of 270 eosinophils/μL of blood, they report positive and negative predictive values of 79% and 91% for predicting sputum eosinophilia of ≥3%, which is in line with a recent similar study in Clinical and Experimental Allergy by Zhang and colleagues who identified 260 eosinophils/μL of blood as an optimal cut-off.5 Overall, the finding that blood eosinophil counts are a reasonably accurate biomarker of sputum eosinophil percentage in two rigorously conducted independent studies is encouraging, as blood eosinophil counts are readily obtained from a complete blood count with differential, a test that is convenient and widely available …
Demand Forecasting and Pricing Decision with the Entry of Store Brand under Various Information Sharing Scenarios

In this research, we discuss three different approaches to generate demand forecasting and pricing decision for mix of national brand and store brand products in the era of big data. We derive the equilibrium wholesale price and retail price for the national brand products, and the equilibrium retail price for the store brand products based on demand forecast under three different information scenarios, including Noninformation Sharing (N), Information Sharing (I), and Retailer Forecasting (R). We comprehensively discuss how information collection, information sharing, forecast accuracy under era of big data affect firms’ prices and profits. Our numerical experiments illustrate and verify our analytical findings and provide further managerial insights and interpretations.
1 2 3 Natural Merodiploidy of the lux-rib Operon of Photobacterium leiognathi 4 from Coastal Waters of Honshu , Japan 5 6

from Coastal Waters of Honshu, Japan 5 6 Jennifer C. Ast, Henryk Urbanczyk, and Paul V. Dunlap* 7 Department of Ecological and Evolutionary Biology, University of Michigan, 8 Ann Arbor, Michigan, USA 9 10 11 12 Running title: Multiple lux-rib operons in P. leiognathi 13 14 15 16 *Corresponding author. Mailing address: Department of Ecological and Evolutionary Biology, 17 University of Michigan, 830 North University Ave., Ann Arbor, MI 48109-1048. 18 Phone +1 734 615-9099. Fax +1 734 763-0544. E-mail: pvdunlap@umich.edu 19 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Bacteriol. doi:10.1128/JB.00672-07 JB Accepts, published online ahead of print on 22 June 2007
What do first-year university students in Ontario, Canada, know about First Nations, Métis, and Inuit peoples and topics?

We disseminated the Awareness Questionnaire to the first-year cohorts at 10 Ontario universities in 2014. Co-designed with over 200 First Nations, Metis, and Inuit educators and community members across Ontario, the survey investigated how students are learning to think about colonialism and its relationship to Indigenous peoples and Canadian society. Statistical analysis of 2,899 student responses reveals that first-year universitystudents who graduated from Ontario high schools are substantially unaware of Indigenous presence and vitality. The majority of students do not understand the fundamental laws structuring conditions of life for First Nations, Metis, and Inuit people or the contributions Indigenous peoples make to all aspects of Canadian society. Although they know slightly more about what is happening with regard to Indigenous peoples today,students have little sense of the historical circumstances and forces that shape current events. Arguably, students are this ignorant because the Ontario K–12 curriculum, which remains deeply inadequate, is the primary source of information for most students. However, when students have opportunities to engage with Indigenous perspectives and topics, it can make a difference to what students know and think. These results indicate that curricular reform is key to eradicating mass ignorance but cannot occur in isolation. Teacher education programs must play a central role in enacting the promise of new curricular emphases.
A new data model for digital preservation and digital archiving for the French Administration: VITAM model on NoSQL technologies

The three ministries in charge of public digital archiving in France (Culture, Defence and Foreign Affairs) decided to build a specific system in order to preserve their digital information. The main challenge is the management of all the data and metadata produced by the French State which could be linked to Big data technologies. Since February 2013, these three ministries have done a large experiment (a proof of concept) based on NoSQL technologies, which ended in June 2013. In this paper, we describe our IT approach of this archivistic problem, our new data model and the results of this inter-ministerial study.
The BEACH Protein LvsB Is Localized on Lysosomes and Postlysosomes and Limits Their Fusion with Early Endosomes

The Chediak–Higashi syndrome (CHS) is a genetic disorder caused by the loss of the BEACH protein Lyst. Impaired lysosomal function in CHS patients results in many physiological problems, including immunodeficiency, albinism and neurological problems. Dictyostelium LvsB is the ortholog of mammalian Lyst and is also important for lysosomal function. A knock‐in approach was used to tag LvsB with green fluorescent protein (GFP) and express it from its single chromosomal locus. GFP‐LvsB was observed on late lysosomes and postlysosomes. Loss of LvsB resulted in enlarged postlysosomes, in the abnormal localization of proton pumps on postlysosomes and their abnormal acidification. The abnormal postlysosomes in LvsB‐null cells were produced by the inappropriate fusion of early endosomal compartments with postlysosomal compartments. The intermixing of compartments resulted in a delayed transit of fluid‐phase marker through the endolysosomal system. These results support the model that LvsB and Lyst proteins act as negative regulators of fusion by limiting the heterotypic fusion of early endosomes with postlysosomal compartments.
Hantaan virus enters cells by clathrin-dependent receptor-mediated endocytosis.

The cellular entry of Hantaan virus (HTN) occurs through interactions with beta(3) integrins as cellular receptors. However, the process of HTN infection following attachment to the cell surface is not well understood. Our data indicate that overexpression of a dominant-negative mutant dynamin inhibits HTN internalization and that compounds that block clathrin- but not caveolae-dependent endocytosis also reduce HTN infectivity. In addition, we show that HTN colocalizes with the clathrin heavy chain but not with caveolae. At the early phase of infection HTN colocalizes with EEA-1, an early endosome marker, and later, HTN colocalizes with LAMP-1, a lysosome marker. Cells treated with lysosomotropic agents are largely resistant to infection, suggesting that a low-pH-dependent step is required for HTN infection. These findings demonstrate that HTN enters cells via the clathrin-coated pit pathway and uses low-pH-dependent intracellular compartments for infectious entry.
Transmission Cluster of Multiclass Highly Drug-Resistant HIV-1 Among 9 Men Who Have Sex With Men in Seattle/King County, WA, 2005-2007

Background:From 2005 through 2007, Seattle health care providers identified cases of primary multiclass drug-resistant (MDR) HIV-1 with common patterns of resistance to antiretrovirals (ARVs). Through surveillance activities and genetic analysis, the local Health Department and the University of Washington identified phylogenetically linked cases among ARV treatment-naive and -experienced individuals. Methods:HIV-1 pol nucleotide consensus sequences submitted to the University of Washington Clinical Virology Laboratory were assessed for phylogenetically related MDR HIV. Demographic and clinical data collected included HIV diagnosis date, ARV history, and laboratory results. Results:Seven ARV-naive men had phylogenetically linked MDR strains with resistance to most ARVs; these were linked to 2 ARV-experienced men. All 9 men reported methamphetamine use and multiple anonymous male partners. Primary transmissions were diagnosed for more than a 2-year period, 2005-2007. Three, including the 2 ARV-experienced men, were prescribed ARVs. Conclusions:This cluster of 9 men with phylogenetically related highly drug-resistant MDR HIV strains and common risk factors but without reported direct epidemiologic links may have important implications to public health. This cluster demonstrates the importance of primary resistance testing and of collaboration between the public and private medical community in identifying MDR outbreaks. Public health interventions and surveillance are needed to reduce transmission of MDR HIV-1.
An Introduction to Genetic Engineering

The fourth edition of this popular textbook retains its focus on the fundamental principles of gene manipulation, providing an accessible and broad-based introduction to the subject for beginning undergraduate students. It has been brought thoroughly up to date with new chapters on the story of DNA and genome editing, and new sections on bioethics, significant developments in sequencing technology and structural, functional and comparative genomics and proteomics, and the impact of transgenic plants. In addition to chapter summaries, learning objectives, concept maps, glossary and key word lists the book now also features new concluding sections, further reading lists and web-search activities for each chapter to provide a comprehensive suite of learning resources to help students develop a flexible and critical approach to the study of genetic engineering.