Miracle-dz/UniFAR-FTUs huggingface dataset:
Migraine as a predictor of mortality: The HUNT study

Background There is conflicting evidence for the association between migraine and increased mortality risk. The aim of this study was to investigate the relationship between migraine and non-migrainous headache, and all-cause mortality and cardiovascular mortality. Methods In this prospective population-based cohort study from Norway, we used baseline data from the second Nord-Trøndelag Health Survey (HUNT2), performed between 1995 and 1997 in the County of Nord-Trøndelag. These data were linked with a comprehensive mortality database with follow-up through the year 2011. A total of 51,853 (56% of invited) people were categorized based on their answers to the headache questions in HUNT2 (headache free, migraine or non-migrainous headache). Hazard ratios (HRs) of mortality during a mean of 14.1 years of follow-up were estimated using Cox regression. Results During the follow-up period 9408 died, 4321 of these from cardiovascular causes. There was no difference in all-cause mortality between individuals with migraine and non-migrainous headache compared to those without headache or between headache status and mortality by cardiovascular disease. There was, however, among men with migraine without aura a reduced risk of death by cardiovascular diseases (HR 0.72, 95% confidence interval 0.56–0.93). This relationship was not evident in women. Conclusion In this large, prospective cohort study there was no evidence for a higher all-cause mortality or cardiovascular mortality among individuals with migraine.
Ethylene Insensitivity Conferred by the Green-ripe and Never-ripe 2 Ripening Mutants of Tomato1

The ripening of a fleshy fruit represents the summation of an array of biochemical processes that are regulated by interactions between developmental programs and environmental inputs. Analysis of tomato (Solanum lycopersicum) mutants and inhibitor studies indicate that ethylene is necessary for full development of the ripening program of climacteric fruit such as tomato, yet ethylene alone is not sufficient. This suggests that an interaction between ethylene and nonethylene (or developmental) pathways mediates ripening. In this study, we have examined the physiological basis for ripening inhibition of the dominant Green-ripe (Gr) and Never-ripe 2 (Nr-2) mutants of tomato. Our data suggest that this inhibition is due to ethylene insensitivity in mutant fruit. Further investigation of ethylene responses in Gr and Nr-2 plants also revealed weak ethylene insensitivity during floral senescence and abscission and, during inhibition of root elongation, a phenotype associated with the triple response. However, ethylene-induced inhibition of hypocotyl elongation and petiole epinasty are normal in Gr and Nr-2, suggesting that these loci regulate a subset of ethylene responses. We have mapped both dominant mutations to a 2-cM overlapping region of the long arm of chromosome 1 of tomato, a region not previously linked to any known ethylene signaling loci. The phenotypic similarity and overlapping map location of these mutations suggest Gr and Nr-2 may be allelic and may possibly encode a novel component of the ethylene response pathway.
Novel transcriptome resources for three scleractinian coral species from the Indo-Pacific

Abstract Transcriptomic resources for coral species can provide insight into coral evolutionary history and stress-response physiology. Goniopora columna, Galaxea astreata, and Galaxea acrhelia are scleractinian corals of the Indo-Pacific, representing a diversity of morphologies and life-history traits. G. columna and G. astreata are common and cosmopolitan, while G. acrhelia is largely restricted to the coral triangle and Great Barrier Reef. Reference transcriptomes for these species were assembled from replicate colony fragments exposed to elevated (31°C) and ambient (27°C) temperatures. Trinity was used to create de novo assemblies for each species from 92–102 million raw Illumina Hiseq 2 × 150 bp reads. Host-specific assemblies contained 65 460–72 405 contigs, representing 26 693–37 894 isogroups (∼genes) with an average N50 of 2254. Gene name and/or gene ontology annotations were possible for 58% of isogroups on average. Transcriptomes contained 93.1–94.3% of EuKaryotic Orthologous Groups comprising the core eukaryotic gene set, and 89.98–91.92% of the single-copy metazoan core gene set orthologs were complete, indicating fairly comprehensive assemblies. This work expands the complement of transcriptomic resources available for scleractinian coral species, including the first reference for a representative of Goniopora spp. as well as species with novel morphology.
Music therapy in moderate and severe dementia of Alzheimer's type: a case–control study

Background: Music therapy is a potential non-pharmacological treatment for the behavioral and psychological symptoms of dementia, but although some studies have found it to be helpful, most are small and uncontrolled. Methods: This case–control study was carried out by qualified music therapists in two nursing homes and two psychogeriatric wards. The participants were 38 patients with moderate or severe Alzheimer's disease (AD) assigned randomly to a music therapy group and a control group. Results: The study showed a significant reduction in activity disturbances in the music therapy group during a 6-week period measured with the Behavior Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD). There was also a significant reduction in the sum of scores of activity disturbances, aggressiveness and anxiety. Other symptoms rated by subscales of the BEHAVE-AD did not decrease significantly. Four weeks later the effects had mostly disappeared. Conclusions: Music therapy is a safe and effective method for treating agitation and anxiety in moderately severe and severe AD. This is in line with the results of some non-controlled studies on music therapy in dementia.
Comprehensive Analysis of Copy Number and Allele Status Identifies Multiple Chromosome Defects Underlying Follicular Lymphoma Pathogenesis

Purpose: Follicular lymphoma (FL) constitutes the second most common non-Hodgkin's lymphoma in the Western world. The clinical course is variable and only in part explained by known tumor-intrinsic or -extrinsic factors. FL carries the hallmark chromosomal translocation t(14;18), deregulating the expression of Bcl-2, but this is not sufficient to explain either FL biology or clinical behavior. Experimental Design: We have employed high-density genomic profiling technology using the Affymetrix 50K-XbaI oligonucleotide single nucleotide polymorphism–chip platform to interrogate the genomes of 58 fluorescence-activated cell–sorted (FACS) FL specimens for chromosomal copy number changes and 46 specimens for loss of heterozygosity (LOH). Results: We report (a) previously unknown high-frequency copy-neutral LOH (uniparental disomy) in FL on chromosomes 1p (∼50%) and 6p (∼30%); (b) that del6q is complex, as reported, with at least two regions of minimal common loss at 6q13-15 and 6q23-24, and that in addition, ∼8% of FL specimens contain a homozygous deletion at 6q23.3-24.1 that spans the negative NFκB regulator A20 and the p53 apoptosis effector PERP; (c) that combined analysis of chromosome 17p for LOH, copy number, and p53 mutations shows that most p53 mutations in FL do not involve del17p. Finally, we map high-frequency LOH with and without copy loss on chromosomes 9p, 10q, and 16p and genomic gains on 2p15-16 and 8q24.22-24.3. Conclusions: This comprehensive description of the pathologic anatomy of the FL genome uncovers novel genetic lesions and should aid with identification of genes relevant to FL biology and clinical behavior.
Bearings-only path following with a vision-based potential field

In this paper, we present a vision-based path following algorithm for a non-holonomic wheeled platform. The algorithm is based on choosing control actions that minimise the value of a potential field cost function calculated directly from the image plane. The algorithm is suitable for teach and replay or leader follower implementations where the desired path is represented as a collection of images. The algorithm computes the cost function based on the relative bearings of features matched between the current and previously observed images. A forward prediction step is then used to determine the control action that will lead to the greatest reduction in the cost function. The algorithm is demonstrated on a 400 m path in an outdoor environment where the accuracy is shown to be similar to that of differential GPS.
Differentially Private Real-Time Data Release over Infinite Trajectory Streams

Recent emerging mobile and wearable technologies make it easy to collect personal spatiotemporal data such as activity trajectories in daily life. Releasing real-time statistics over trajectory streams produced by crowds of people is expected to be valuable for both academia and business, answering questions such as "How many people are in Central Station now? " However, analyzing these raw data will entail risks of compromising individual privacy. ϵ-Differential Privacy has emerged as a de facto standard for private statistics publishing because of its guarantee of being rigorous and mathematically provable. Since user trajectories will be generated infinitely, it is difficult to protect every trajectory under ϵ-differential privacy. To this end, we propose a flexible privacy model of ℓ-trajectory privacy to ensure every length of ℓ trajectories under protection of ϵ-differential privacy. Then we hierarchically design algorithms to satisfy ℓ-trajectory privacy. Experiments using four real-life datasets show that our proposed algorithms are effective and efficient.
Development and Validation of a Photonumeric Scale for Evaluation of Volume Deficit of the Temple

BACKGROUND A validated scale is needed for objective and reproducible comparisons of temple appearance before and after aesthetic treatment in practice and clinical studies. OBJECTIVE To describe the development and validation of the 5-point photonumeric Allergan Temple Hollowing Scale. METHODS The scale was developed to include an assessment guide, verbal descriptors, morphed images, and real subject images for each grade. The clinical significance of a 1-point score difference was evaluated in a review of image pairs representing varying differences in severity. Interrater and intrarater reliability was evaluated in a live-subject validation study (N = 298) completed during 2 sessions occurring 3 weeks apart. RESULTS A score difference of ≥1 point was shown to reflect a clinically significant difference (mean [95% confidence interval] absolute score difference, 1.1 [0.94–1.26] for clinically different image pairs and 0.67 [0.51–0.83] for not clinically different pairs). Intrarater agreement between the 2 validation sessions was almost perfect (mean weighted kappa = 0.86). Interrater agreement was almost perfect during the second session (0.81, primary endpoint). CONCLUSION The Allergan Temple Hollowing Scale is a validated and reliable scale for physician rating of temple volume deficit.
AgentWeb Gateway - a middleware for dynamic integration of multi agent system and Web services framework

Web services framework has been evolved in context of convergence of Web and service oriented computing and then to Web services resource framework acting as basis for grid computing. It provides a loose coupled and implementation neutral infrastructure for distributed applications. On the other hand, multi agent systems has evolved as distributed system in context of autonomic computing having ultimate aim of self-managing systems to overcome their rapidly growing complexity and to enable their further growth. In this paper, we present our solution for dynamic and seamless integration of type the distributed systems. It would help in facilitating the requirements of next generation distributed applications requiring higher demands and complexity. The AgentWeb Gateway acts as middleware between both the technologies for dynamic integration and provides protocol transformations including service discovery, service description and service invocation.
Parallel Tag Clouds to explore and analyze faceted text corpora

Do court cases differ from place to place? What kind of picture do we get by looking at a country's collection of law cases? We introduce Parallel Tag Clouds: a new way to visualize differences amongst facets of very large metadata-rich text corpora. We have pointed Parallel Tag Clouds at a collection of over 600,000 US Circuit Court decisions spanning a period of 50 years and have discovered regional as well as linguistic differences between courts. The visualization technique combines graphical elements from parallel coordinates and traditional tag clouds to provide rich overviews of a document collection while acting as an entry point for exploration of individual texts. We augment basic parallel tag clouds with a details-in-context display and an option to visualize changes over a second facet of the data, such as time. We also address text mining challenges such as selecting the best words to visualize, and how to do so in reasonable time periods to maintain interactivity.
"But I'm a Language Teacher!" Dual Immersion Teacher Identities in a Complex Policy Context.

This qualitative study examined dual immersion teachers’ identities as they engaged in policy implementation within their school, collaborating in professional learning communities (PLC) with one-way immersion teachers. Data derived from participant observation, interviews, and interpersonal process recall were analyzed through a theoretical lens blending communities of practice theories with theories on identity formation. Findings suggested that the requirement to collaborate across instructional contexts helped the dual immersion teachers to form strong and unique identities that sometimes conflicted with the requirements of their PLC work. The dual immersion teachers’ identities were shaped by their roles in the dual immersion program working with ELL students and by their work on PLC teams, and they often felt misunderstood by their colleagues who were not dual immersion teachers. This study has implications for leadership practice and policy research, suggesting that teachers’ identities can impact on their engagement with school policies.
Detection of varicella‐zoster virus DNA in 414 human trigeminal ganglia from cadavers by the polymerase chain reaction: A comparison of the detection rate of varicella‐zoster virus and herpes simplex virus type 1

Investigation of varicella‐zoster virus (VZV) is important epidemiologically, and determination of its prevalence rate in human trigeminal ganglia is important to provide surveillance data. To date, studies on VZV detection in trigeminal ganglia have used specimens obtained from a relatively limited number of cadavers. This study attempted to detect VZV DNA as well as Herpes simplex virus type 1 (HSV‐1) DNA by the polymerase chain reaction (PCR) from 414 samples of trigeminal ganglia obtained from 207 cadavers selected at random. The detection rate was examined to determine whether there were significant differences in the positive rate between the left and right trigeminal ganglia, males and females, and among age groups. A relationship was found between the positive rates for VZV and HSV‐1. VZV DNA was detected in 391 of the trigeminal ganglia (94.4%) and 201 of the cadavers (97.1%) in 121/124 males and 80/83 females. HSV‐1 DNA was detected in 251 of the samples (60.6%) and 134 of the cadavers (64.7%) in 72/124 males and 62/83 females. There was no significant difference for either virus in the detection rates between the left and right trigeminal ganglia and males and females. Age and positivity for HSV‐1, but not VZV, showed a significant relationship. All 134 cadavers positive for HSV‐1 were also positive for VZV. VZV and HSV‐1 become latent in bilateral trigeminal ganglia, and are not affected by gender. The prevalence of HSV‐1 was greater in advanced age, and the HSV‐1‐positive rate was correlated with the VZV‐positive rate. J. Med. Virol. 82:345–349, 2010. © 2009 Wiley‐Liss, Inc.
Low-Power Sensor Stack Tunability for Multi-Radio Support

The challenge in realizing a multi-radio stack in sensor node system architectures is optimization for radio protocol processing and low-power considerations. Since smart sensor node platforms typically would have computation blocks that can handle minimal instructions for handling data, the paradigm for extending the sensors' utilities and deployment scope necessitates multi-radio support on a single optimized stack. Our idea is to make an integrated stack tunable and optimized to the sensor node platform architecture. In this paper, we explore tunability of radio protocol stacks from the perspective of multi-radio support while keeping power consumption as a performance metric in sensor nodes. Our approach is based on a scheduler design based on traffic conditioning, along with a reconfigurable frame parser that helps in pre-processing of the radio protocol packets before they are scheduled according to a choice set of MAC and PHY units that form the vertical flow of protocol stack processing run-time. This is currently work-in-progress and we are developing our concepts and test prototype implementation.
Evaluation of Activities of Daily Living Ability and Awareness among Clients in a Forensic Psychiatry Evaluation Unit in Sweden

Introduction: The aim of this exploratory study was to investigate activities of daily living (ADL) functioning for clients in a forensic psychiatry evaluation unit and also to investigate the relationship between ADL functioning and awareness of their ability to perform ADL. Method: The sample consisted of 35 participants at a forensic psychiatry evaluation unit in Sweden. ADL was investigated using the Assessment of Motor and Process Skills (AMPS) and awareness of ability was investigated using the Assessment of Awareness of Ability (A3). Results: The ADL mean motor ability for the participants was 1.68 logits and the process ability showed an ADL mean value of 0.83 logit. The mean value of awareness was 0.60 logit. A majority of the participants demonstrated ability measures below the cut-off criteria in the AMPS, which indicates that they might need support to function in the community. There was also a significant relationship between awareness of ability and ADL motor ability (rho = 0.49, p<0.01) and ADL process ability (rho = 0.77, p<0.01). Conclusion: Clients in forensic psychiatry demonstrate limited ability in ADL, associated with a limited awareness. Clients in forensic psychiatry may also need assistance to live in the community, which suggests that occupational therapy may be offered to these clients in order to prepare them to manage in the community.
Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside

Nicotine is an environmental toxicant in tobacco waste, imposing a serious hazard for human health. Some bacteria including Pseudomonas spp. strains are able to metabolize nicotine to non‐toxic compounds. The pyrrolidine pathway of nicotine degradation in Pseudomonas putida S16 has recently been revealed. The maleate isomerase (Pp‐Iso) catalyses the last step in nicotine degradation of P. putida S16, the cis‐trans isomerization of maleate to fumarate. In this study, we determined the crystal structures of both wild type isomerase by itself and its C200A point mutant in complex with its substrate maleate, to resolutions of 2.95 Å and 2.10 Å respectively. Our structures reveal that Asn17 and Asn169 play critical roles in recognizing the maleate by site‐directed mutants' analysis. Surprisingly, our structure shows that the maleate is completely wrapped inside the isomerase. Examination of the structure prompted us to hypothesize that the β2‐α2 loop and the β6‐α7 loop have a breathing motion that regulates substrate/solvent entry and product departure. Our results of molecular dynamics simulation and enzymatic activity assay are fully consistent with this hypothesis. The isomerase probably uses this breathing motion to prevent the solvent from entering the active site and prohibit unproductive side reactions from happening.
Energy Efficient Collaborative Spectrum Sensing Based on Trust Management in Cognitive Radio Networks

An energy efficient collaborative spectrum sensing (EE-CSS) protocol, based on trust management, is proposed. The protocol achieves energy efficiency by reducing the total number of sensing reports exchanged between the honest secondary users (HSUs) and the secondary user base station (SUBS) in a traditional collaborative spectrum sensing (T-CSS) protocol. It is shown that the minimum total number of sensing reports required to satisfy a target global false alarm (FA) and missed detection (MD) probabilities in T-CSS is higher than that in EE-CSS. Expressions for the steady-state average SU trust value τ̅ and total number N̅ of SU sensing reports transmitted are derived, as is an expression for the energy consumption, in EE-CSS and T-CSS. The global FA and detection probabilities Qf and Qd are obtained for a commonly used decision fusion technique. The impact of link outages on τ̅, N̅, Qf, and Qd is also analyzed. The results show that the energy consumption in EE-CSS can be much lower compared to that in T-CSS for long range communications where the transmit energy is dominant.
A Practical Interprocedural Pointer Analysis

In this paper we propose an eecient and eeective algorithm to perform ow-insensitive interprocedural pointer analysis which can eliminate impossible paths. To make the algorithm eecient, we design a decoupled analysis framework where only the pointer information in each function is extracted in the function-level analysis phase, and processed with other function's pointer information in the interprocedural analysis phase. To be eeective, our analysis can disambiguate accesses to a single eld in a structure and union, for both stack-and heap-based storage. We have implemented the algorithm in the IMPACT compiler and evaluated its feasibility for the complete suite of SPECint92 and SPECint95 benchmarks.
‘Flexible bio-citizenship’ and international medical travel: Transnational mobilities for care in Asia

International medical travel (IMT) challenges the notion of health care as a responsibility of a nation-state to its citizens, tied to the territory of a nation-state. As patients travel for medical care, they invoke not territorialised notions of citizenship, but make new claims. In this article, the authors propose the term ‘flexible bio-citizenship’ that extends the notion of ‘flexible citizenship’ to describe transnational mobilities for the accumulation of biovalue. They argue that people who travel for medical care come from a variety of backgrounds, identities and circumstances for whom the physical and economic ability to travel and cross borders is a form of flexible social capital enabling them to access levels of care otherwise inaccessible to them. The article explores the implications upon citizenship for a diverse range of people who travel for their health care: from highly mobile cosmopolitan professional expatriate workers, regional border crossers, migrant workers, those who cannot afford care at home, patients whose status makes treatments unavailable, and outsourced patients forced to travel for care. Their mobility allows them to gain biovalue but also alters their citizenship relationships and perspectives.