Miracle-dz/UniFAR-FTUs huggingface dataset:
Classification of human carcinoma cells using multispectral imagery

In this paper, we present a technique for automatically classifying human carcinoma cell images using textural features. An image dataset containing microscopy biopsy images from different patients for 14 distinct cancer cell line type is studied. The images are captured using a RGB camera attached to an inverted microscopy device. Texture based Gabor features are extracted from multispectral input images. SVM classifier is used to generate a descriptive model for the purpose of cell line classification. The experimental results depict satisfactory performance, and the proposed method is versatile for various microscopy magnification options.
Inverted-U Aggregate Investment Curves in a Dynamic Game of Advertising

We revisit the relationship between market power and firms' investment incentives in a noncooperative differential oligopoly game in which firms sell differentiated goods and invest in advertising to increase the brand equity of their respective goods. The feedback equilibrium obtains under open-loop rules, and aggregate expenditure on goodwill takes an inverted-U shape under both Cournot and Bertrand behaviour, provided product differentiation is sufficiently high. Total industry expenditure is higher under Cournot competition.
Quenching correction for in vivo chlorophyll fluorescence acquired by autonomous platforms: A case study with instrumented elephant seals in the Kerguelen region (Southern Ocean)

As the proxy for Chlorophyll a (Chl a) concentration, thousands of fluorescence profiles were measured by instrumented elephant seals in the Kerguelen region (Southern Ocean). For accurate retrieval of Chl a concentrations acquired by in vivo fluorometer, a two‐step procedure is applied: 1) A predeployment intercalibration with accurate determination by high performance liquid chromatography (HPLC) analysis, which not only calibrates fluorescence in appropriate Chl a concentration units, but also strongly reduces variability between fluorometers, and 2) a profile‐by‐profile quenching correction analysis, which effectively eliminates the fluorescence quenching issue at surface around noon, and results in consistent profiles between day and night. The quenching correction is conducted through an extrapolation of the deep fluorescence value toward surface. As proved by a validation procedure in the Western Mediterranean Sea, the correction method is practical and relatively reliable when there is no credible reference, especially for deep mixed waters, as in the Southern Ocean. Even in the shallow mixed waters, the method is also effective in reducing the influence of quenching.
Farmers’ market governance and its role on consumer motives and outcomes

ABSTRACT Local food systems and farmers' markets across the USA have experienced unprecedented growth and development in the past 20 years. While scholarship has examined participant demographics and motives for engaging in farmers' markets, few studies have considered the coupled nature of those attending the markets with institutional governance systems used for market coordination. This study examined participation in farmers' markets under the framework of high and low market governance systems, specifically considering the demographics, values for local foods, motives for attending farmers' markets, and outcomes of the experience based on the dichotomous governance classification. Governance was characterized using four attributes: market rules or policies, paid employee(s), a rule governing geography of food origin, and affiliation with an organisation or agency. Our results suggest that market governance may impact (1) which consumers attend the market, (2) motives among those who attend the market, and (3) satisfaction outcome levels among market participants. By better understanding how the emerging governance system impacts who ultimately attends the market (and the outcomes of the experience), agencies coordinating farmers' markets and market managers can ultimately improve the market's reach and experience with greater intentionality.
Simplified mechanism for new particle formation from methanesulfonic acid, amines, and water via experiments and ab initio calculations

Airborne particles affect human health and significantly influence visibility and climate. A major fraction of these particles result from the reactions of gaseous precursors to generate low-volatility products such as sulfuric acid and high-molecular weight organics that nucleate to form new particles. Ammonia and, more recently, amines, both of which are ubiquitous in the environment, have also been recognized as important contributors. However, accurately predicting new particle formation in both laboratory systems and in air has been problematic. During the oxidation of organosulfur compounds, gas-phase methanesulfonic acid is formed simultaneously with sulfuric acid, and both are found in particles in coastal regions as well as inland. We show here that: (i) Amines form particles on reaction with methanesulfonic acid, (ii) water vapor is required, and (iii) particle formation can be quantitatively reproduced by a semiempirical kinetics model supported by insights from quantum chemical calculations of likely intermediate clusters. Such an approach may be more broadly applicable in models of outdoor, indoor, and industrial settings where particles are formed, and where accurate modeling is essential for predicting their impact on health, visibility, and climate.
Effect of DC Plasma Electrolytic Oxidation on Surface Characteristics and Corrosion Resistance of Zirconium

Zr is a valve metal, the biocompatibility of which is at least on par with Ti. Recently, numerous attempts of the formation of bioactive coatings on Zr by plasma electrolytic oxidation (PEO) in solutions that were based on calcium acetate and calcium β-glycerophosphate were made. In this study, the direct current (DC) PEO of commercially pure zirconium in the solutions that contained Ca(H2PO2)2, Ca(HCOO)2, and Mg(CH3COO)2 was investigated. The treatment was conducted at 75 mA/cm2 up to 200, 300, or 400 V. Five process stages were discerned. The treatment at higher voltages resulted in the formation of oxide layers that had Ca/P or (Mg+Ca)/P ratios that were close to that of hydroxyapatite (Ca/P = 1.67), determined by SEM/EDX. The corrosion resistance studies were performed using electrochemical impedance spectroscopy (EIS) and DC polarization methods. R(Q[R(QR)]) circuit model was used to fit the EIS data. In general, the coatings that were obtained at 200 V were the most corrosion resistant, however, they lacked the porous structure, which is typical for PEO coatings, and is sought after in the biomedical applications. The treatment at 400 V resulted in the formation of the coatings that were more corrosion resistant than those that were obtained at 300 V. This was determined mainly by the prevailing plasma regime at the given process voltage. The pitting resistance of Zr was also improved by the treatment, regardless of the applied process conditions.
A Mechanized Proof in Coq of the Type Soundness of Core L 3

Statically-typed programming languages have type checkers that detect certain invalid operations, known as type errors, at compile time, reducing the number of errors that would arise at run time. Type checkers are based on a set of rules that determine whether a program contains type errors, which is referred to as a type system. A type system is said to accept programs that it considers type-safe and reject programs it considers to have type errors. Type soundness is the property that the type system rejects all programs that contain invalid operations, and thus guarantees all type-safe programs will run successfully. It is not trivial to determine whether a type system is sound. Not only should type systems reject all invalid programs, they should accept as many valid programs as possible. This requires creating more sophisticated type systems with more complex rules. This added complexity creates opportunities for subtle issues to prevent the type system from being sound. The solution is to use mathematics to prove that a type system does not allow any invalid programs. The language being studied is specified using a formal definition that gives precise meaning to the constructs of the language. This allows type soundness to be represented as a logical formula, which can be proven true by considering all possible expressions and types in the language. If the logical formula for type soundness is successfully proven, it means that a counterexample, no matter how elusive it might be, cannot exist. It is common for research papers that present a new programming language or type system to include a proof of its type soundness.
Implications of changing El Niño patterns for biological dynamics in the equatorial Pacific Ocean

El Niño events are known to strongly affect biological production and ecosystem structure in the tropical Pacific. Understanding and predicting biological processes in this area are hampered because the existing in situobserving system focuses primarily on physical measurements and does not observe key biological parameters; the only high spatial and temporal resolution biology‐related observations are from the global array of ocean color satellites which provide an estimate of surface chlorophyll concentrations only. Since the 1990s, an apparent shift of the El Niño maximum sea‐surface temperature (SST) warm anomaly from the eastern to the central equatorial Pacific has frequently been observed. Satellite observations show significant changes in chlorophyll‐a (Chl‐a), new production (NP) and total primary production (PP) in the equatorial Pacific associated with these new central Pacific (CP) El Niño events (also called El Niño Modoki) relative to eastern Pacific El Niños. During CP‐El Niños, NP, Chl‐a and PP in the central basin are depressed relative to EP‐El Niños and lower values of Chl‐a and PP coincide spatially with higher SST in the central Pacific. While surface Chl‐a, and integrated NP and PP over the entire equatorial band, decrease during both CP and EP‐El Niños, the magnitude of this decrease seems to depend more on the intensity than type of event. The changing spatial patterns have significant implications for equatorial biological dynamics if, as has been suggested, CP‐El Niños increase in frequency in the future.
Basic concepts about genes, inactivity and aging

Remarkably, 80‐year‐old humans who have partaken in lifelong aerobic or strength training have maximal aerobic capacities or muscle strengths comparable with that of sedentary individuals aged 50 or 55‐year‐old, respectively. Such delays in functional aging are clinically significant because lower aerobic and lower strength capacities increase the risk of premature death. In this short review, we speculate that the lack of daily physical activity induces evolutionarily selected mechanisms to use or lose, one of which is related to nutritional status.
A Blood Hematocrit Test Strip

This paper reports a self-propelled microfluidic hematocrit (HCT) test that uses the correlation between blood hematocrit and wicking distance of blood in a special paper matrix. The enabling feature is a novel blood volume metering method that allows sampling from the fingertip and reliably generates a highly precise blood volume of $47.7 \pm 1.9\ \mu 1$ (CV 4%) that is transferred into a porous paper matrix. A dissolvable valve ensures a relaxed time window for blood sampling, making it highly user-friendly and resilient to overfilling. The presented hematocrit test strip poses a simple, cheap, equipment-free solution for patient-centric hematocrit measurements.
Reconstruction of the deep history of "Parent-Daughter" relationships among vertebrate paralogs

Gene duplication is a major mechanism through which new genetic material is generated. Although numerous methods have been developed to differentiate the ortholog and paralogs, very few differentiate the "Parent-Daughter" relationship among paralogous pairs. As coined by the Mira et al, we refer the "Parent" copy as the paralogous copy that stays at the original genomic position of the "original copy" before the duplication event, while the "Daughter" copy occupies a new genomic locus. Here we present a novel method which combines the phylogenetic reconstruction of duplications at different evolutionary periods and the synteny evidence collected from the preserved homologous gene orders. We reconstructed for the first time a deep evolutionary history of "Parent-Daughter" relationships among genes that were descendants from 2 rounds of whole genome duplications (2R WGDs) at early vertebrates and were further duplicated in later ceancestors like early Mammalia and early Primates. Our analysis reveals that the "Parent" copy has significantly fewer accumulated mutations compared with the "Daughter" copy since their divergence after the duplication event. More strikingly, we found that the "Parent" copy in a duplication event continues to be the "Parent" of the younger successive duplication events which lead to "grand-daughters".
Seasonal variations in body composition, maximal oxygen uptake, and gas exchange threshold in cross-country skiers

Introduction In order to ensure that athletes achieve their highest performance levels during competitive seasons, monitoring their long-term performance data is crucial for understanding the impact of ongoing training programs and evaluating training strategies. The present study was thus designed to investigate the variations in body composition, maximal oxygen uptake (VO2max), and gas exchange threshold values of cross-country skiers across training phases throughout a season. Materials and methods In total, 15 athletes who participate in international cross-country ski competitions voluntarily took part in this study. The athletes underwent incremental treadmill running tests at 3 different time points over a period of 1 year. The first measurements were obtained in July, during the first preparation period; the second measurements were obtained in October, during the second preparation period; and the third measurements were obtained in February, during the competition period. Body weight, body mass index (BMI), body fat (%), as well as VO2max values and gas exchange threshold, measured using V-slope method during the incremental running tests, were assessed at all 3 time points. The collected data were analyzed using SPSS 20 package software. Significant differences between the measurements were assessed using Friedman’s twoway variance analysis with a post hoc option. Results The athletes’ body weights and BMI measurements at the third point were significantly lower compared with the results of the second measurement (p<0.001). Moreover, the incremental running test time was significantly higher at the third measurement, compared with both the first (p<0.05) and the second (p<0.01) measurements. Similarly, the running speed during the test was significantly higher at the third measurement time point compared with the first measurement time point (p<0.05). Body fat (%), time to reach the gas exchange threshold, running speed at the gas exchange threshold, VO2max, amount of oxygen consumed at gas exchange threshold level (VO2GET), maximal heart rate (HRmax), and heart rate at gas exchange threshold level (HRGET) values did not significantly differ between the measurement time points (p>0.05). Conclusion VO2max and gas exchange threshold values recorded during the third measurements, the timing of which coincided with the competitive season of the cross-country skiers, did not significantly change, but their incremental running test time and running speed significantly increased while their body weight and BMI significantly decreased. These results indicate that the cross-country skiers developed a tolerance for high-intensity exercise and reached their highest level of athletic performance during the competitive season.
An Examination of Factors Influencing Collegiate Social Integration of African American Students at a Predominantly White Institution

ii Acknowledgments iv List of Tables viii List of Abbreviations x Chapter 1: Introduction 1 Statement of the Problem 3 Purpose of the Study 4 Research Questions 5 Significance of the Study 5 Limitations 6 Assumptions 6 Definitions of Terms 6 Organization of Study 8 Chapter 2: Review of Literature 9 Social Integration 9 Campus Climate 12 Retention 16 Summary 38
Pregnancy complications and subsequent breast cancer risk in the mother: a Nordic population‐based case–control study

Certain features of pregnancy are important risk factors for breast cancer, such as protection afforded by young age at first birth. Preeclampsia, a pregnancy complication, is associated with reduced maternal breast cancer risk. However, questions remain regarding causality, biological mechanisms and the relation of other hypertensive conditions to risk. We conducted a population‐based case–control study of breast cancer cases (n = 116,196) in parous women identified through linkage of birth and cancer registries in Denmark, Finland, Norway and Sweden (1967–2013), including up to 10 matched controls per case (n = 1,147,192) sampled from the birth registries (complete data were not available on all variables). Odds ratios (ORs) with 95% confidence intervals (CIs) were derived from unconditional logistic regression models including matching factors (country, maternal birth year) and parity. Hypertension diagnosed before pregnancy (OR 0.87; 95% CI 0.78–0.97), gestational hypertension (OR 0.90; 95% CI 0.86–0.93) and preeclampsia (OR 0.91; 95% CI 0.88–0.95) were associated with reduced breast cancer risk. Results remained similar after adjustment for smoking and maternal body mass index before first pregnancy, and were generally similar stratified by parity, age at breast cancer diagnosis, time since first and last birth, sex of the offspring and calendar time. Except for retained placenta (OR 1.14; 95% CI 0.98–1.32), no other pregnancy complication appeared associated with breast cancer risk. The mechanisms mediating the modest risk reductions for history of preeclampsia or hypertension preceding or arising during pregnancy, and possible increased risk with history of retained placenta are unknown and warrant further laboratory, clinical and epidemiological investigation.
Moral Foundations of Welfare Attitudes: The Role of Moral Intuition and Reasoning in Pursuing Social Justice

Abstract The article interconnects the research on welfare attitudes and welfare chauvinism with moral psychology in order to develop an interdisciplinary analytical approach designed for studying attitudes to welfare policies and potentially overcoming the divisions prevalent in many European democracies. It introduces Moral Foundations Theory (MFT) - an empirical approach to analysing intuitions, reasoning, and emotions constituting moral judgment - and outlines its understanding of competing versions of fairness and distributive justice. The potential contributions of MFT are exemplified on a case study situated in contemporary Slovakia which deals with two conflicting conceptions of fairness, as equity and as equality, embodied in the diverging attitudes towards an amendment to the Act on the Assistance in Material Need (2013). The article argues that MFT and related research programmes are irreplaceable components in an interdisciplinary study of the plurality of welfare policy attitudes. It also highlights the transformative potential of MFT and related research programmes in devising interventions aimed at changing (political) attitudes to welfare and reducing their polarisation.
Antithrombin-independent thrombin inhibitors, but not direct factor Xa inhibitors, enhance thrombin generation in plasma through inhibition of thrombin-thrombomodulin-protein C system

Summary There is increasing concern that some anticoagulants can paradoxically increase thrombogenesis under certain circumstances. Previously, we demonstrated that at certain doses a direct thrombin inhibitor, melag-atran, worsens the coagulation status induced by tissue factor (TF) in-jection in a rat model. We utilised an in vitro thrombin generation (TG) assay to determine if direct thrombin inhibitors could enhance TG in human plasma, and whether inhibition of the negative-feedback sys-tem [thrombin-thrombomodulin (TM)-protein C] contributed to the TG enhancement. TG in human plasma was assayed by means of the cali-brated automated thrombography. In this assay, direct factor Xa (FXa) inhibitors such as edoxaban and antithrombin (AT)-dependent anti-coagulants such as heparin did not increase, but simply suppressed TG. AT-independent thrombin inhibitors (melagatran, lepirudin, and active site blocked thrombin (IIai)) increased peak levels of TG (2.0, 1.6, and 2.2-fold, respectively) in the presence of 12 nM recombinant human soluble TM (rhsTM). Melagatran and lepirudin at higher concentrations began to suppress TG. In the absence of rhsTM, the enhancement of peak TG by melagatran decreased to 1.2-fold. Furthermore, in protein C-deficient plasma, AT-independent thrombin inhibitors failed to enhance TG. In addition, a human protein C neutralising antibody increased the peak height of TG in the presence of rhsTM. These results suggest that AT-independent thrombin inhibitors may activate throm-bogenesis by suppression of the thrombin-induced negative-feedback system through inhibition of protein C activation. In contrast, direct FXa inhibitors are more useful than AT-independent thrombin inhibitors in terms of lower possibility of activation of the coagulation pathway.
Aberrant promoter methylation status is associated with upregulation of the E2F4 gene in breast cancer

E2F4 is an important basal transcription factor with the potential to promote tumor growth. Its upregulation in various types of cancer has been linked to numerous genetic factors; however, the nature of the involvement of epigenetic mechanisms, including DNA methylation, remains elusive. In the present study, E2F4 expression profiles were determined in 100 paired breast tumor and control samples, through RT-qPCR using the SYBR® green method. Furthermore, the E2F4 promoter methylation status in each of these samples was assessed using methylation specific PCR, in order to evaluate its impact on gene expression. A two-fold increase in E2F4 gene expression was observed in the breast tumors compared with in their respective controls (P=0.022); of these tumors, ~72% were under-methylated. The change in methylation status was also significantly higher (P<0.001) in the tumor samples. Methylation status was negatively correlated (r=−30) with E2F4 expression profiles, indicating that a decrease in methylation may promote higher expression of E2F4. The two study cohorts (>45 and ≤45 years) had comparable methylation profiles, though they had significantly decreased methylation status compared with controls. Various histo-pathological types also have different methylation profiles, indicating the presence of a tissue specific methylation signature. The results of the present study demonstrated that E2F4 methylation status can have a notable influence on its expression, and that it may have prognostic value in breast carcinogenesis.