Miracle-dz/UniFAR-FTUs huggingface dataset:
Customer perceived value in a cellar door visit: the impact on behavioural intentions

Purpose – The purpose of this paper is to investigate the impact of customer perceived value on behavioural intentions in a cellar door context, and to examine the role of satisfaction as a mediator of the customer perceived value‐behavioural intentions relationship.Design/methodology/approach – A multi‐dimensional measure of customer perceived value was used to determine which aspects of the cellar door experience were valued by visitors and how value dimensions impact on subsequent wine purchase intentions. Data collected from visitors to wineries of the Margaret River and the Swan Valley regions in Western Australia were used to empirically test a model of customer perceived value on behavioural intentions with satisfaction posited as a mediating variable. Multiple regression was employed to test hypothesised relationships.Findings – Results indicate that four out of five dimensions of customer perceived value (service quality, technical quality, price, and social value) have a positive impact on the b.
Role of the Lateral Intraparietal Area in Modulation of the Strength of Sensory-Motor Transmission for Visually Guided Movements

The lateral intraparietal area (LIP) has been implicated as a salience map for control of saccadic eye movements and visual attention. Here, we report evidence to link the encoding of saccades and saliency in LIP to modulation of several other sensory-motor behaviors in monkeys. In many LIP neurons, there was a significant trial-by-trial correlation between the firing rate just before a saccade and the postsaccadic or presaccadic pursuit eye velocity. Some neurons also showed trail-by-trial correlations of the firing rate of LIP neurons with the speed of “glissades” that occur at the end of saccades to stationary targets. LIP–pursuit correlations were spatially specific and were strong only when the target appeared in the receptive/movement field of the neuron under study. We suggest that LIP is a component of a salience representation that modulates the strength of visual-motor transmission for pursuit, and that may play a similar role for many movements, beyond its traditional roles in guiding saccadic eye movements and localizing attention.
Autistic children's difficulty with mental disengagement from an object: Its implications for theories of autism.

Experiment 1 demonstrated that autistic Ss continue to fail a task originally designed as one of strategic deception when there is no opponent present: They perseveratively indicate the target object. We argue that this behavior is better explained in terms of failing to disengage from an object than in terms of a theory-of-mind deficit. To ensure that their difficulties were not due to failure to construe the task in a competitive manner, we ran a 2nd study, on detour reaching. Compared with control Ss, the autistic Ss had great difficulty with the task. We discuss autistic children's difficulties with these 2 tasks in the light of recent evidence that autism is associated with failing executive tasks and argue that viewing the syndrome as an executive deficit has clear advantages
A study on the second order statistics of Nakagami-Hoyt mobile fading channels

In this paper, study of the second order statistics of the Nakagami-Hoyt fading channel model (Nakagami-q model) is considered. Expressions for the level crossing rate (LCR) as well as the average duration of fades (ADF) are derived. It is shown that the obtained analytical quantities best fit the corresponding measurement data for an equivalent mobile satellite channel in the case of an environment with heavy shadowing. This leads to the conclusion that the Nakagami-q model is applicable to realistic mobile communication channels. A simple and efficient deterministic simulation model based on the Rice's sum of sinusoids, which enables the emulation of the fading envelope of the Nakagami-q model with the desired statistics, is also described. A very good agreement is obtained between the simulated, analytical, and experimental statistics.
Finding the needle

Abstract Normal industrial practice in selecting new film and TV drama is to read various texts that describe a screen fiction idea (from a one-line concept to a full screenplay) and to evaluate them as potential screen-works. It appears that no systematic study has been made of the practices of those who read screen ideas professionally. A sample survey of 52 professional screenplay readers within the UK was conducted across winter and spring 2000/01. This attempted to identify a profile of readers, clarify common practice and test a number of hypotheses based around the broad question of what readers seek when evaluating screen ideas. Results show that 90% of readers are white, 62% are male and 48% are over 40; 50% claim to have had over ten years experience in reading scripts; the average reader will see 200–300 ideas per year, but believe only between 1% and 2% of all proposals they see reach production; 83% of readers often or always find the screen idea unattractive; 84% attach little or no importance to adaptations of previously published work. The survey aims to explore the nature of the reading and evaluation process, to establish relevant data, and to suggest further research questions.
What works for offenders and staff: comparing two multi-agency approaches to offender resettlement

Abstract Between 2005 and 2007, the Kent and Medway Resettlement Programme (KMRP) piloted EXODUS (ex-offenders discharged under supervision), a multi-agency support system for identified prolific and priority offenders (IPPOs). Unlike traditional models of multi-agency support, EXODUS agencies work from the same location to maximize support for IPPOs, and inter- and intra-agency support for staff. This study assessed the perceived effectiveness of EXODUS. EXODUS staff and IPPOs were interviewed and their responses compared to those of traditional multi-agency support staff and IPPOs. Analysis showed that EXODUS IPPOs had committed fewer offences since receiving support than did comparison IPPOs. Neither group was more likely to be employed, but of those who were, EXODUS IPPOs were more likely to remain employed than comparison IPPOs. Most, regardless of type of support structure, recommended their programme and staff, although EXODUS IPPOs were more satisfied with the support they received. Staff believed that an expansion of the multi-agency approach was needed and that agency roles should be more clearly defined. EXODUS staff expressed higher efficacy in their own and colleagues’ ability to provide effective support and improved inter-agency relations and support from co-workers. However, EXODUS and comparison staff did not differ in levels of job satisfaction.
Design of interactive television programs

This paper presents results from a set of design sessions held in a broadcasting company. The aim of research was to find a user centered design method which includes the future users into the product development in the early stages of new product design. In this case, the products were interactive television programs and applications for digital television. The study also aims at creating a design method with the user study participants as equal research partners with the designers. The study started with a user study in study participants' home environment. The user study results, a set of user profiles, was taken to a broadcasting company. A series of five design sessions with participants from the broadcasting company followed. New concepts of interactive television programs were designed during the design sessions. The study resulted in new concepts of interactive television programs and services for digital television that were created by both TV viewers and designers.
Modelling the diurnal cycle of tropical convection across the ‘grey zone’

We present the results of simulations carried out with the Met Office Unified Model at 12, 4 and 1.5 km resolution for a large region centred on West Africa using several different representations of the convection processes. These span a range of resolutions from much coarser than the size of the convection processes to cloud‐system‐resolving and thus encompass the intermediate ‘grey zone’. The diurnal cycle in the extent of convective regions in the models is tested against observations from the Geostationary Earth Radiation Budget instrument on Meteosat‐8. By this measure, the two best‐performing simulations are a 12 km model without convective parametrization, using Smagorinsky‐style subgrid‐scale mixing in all three dimensions, and a 1.5 km simulation with two‐dimensional Smagorinsky mixing. Of these, the 12 km model produces a better match to the magnitude of the total cloud fraction but the 1.5 km one results in better timing for its peak value. The results suggest that the previously reported improvement in the representation of the diurnal cycle of convective organization in the 4 km model compared with the standard 12 km configuration is principally a result of the convection scheme employed rather than the improved resolution per se. The details of this result and implications for high‐resolution model simulations are discussed.
Pharmacokinetics and Pharmacogenetics of Selective Serotonin Reuptake Inhibitors During Pregnancy: An Observational Study

Background: An involvement of selective serotonin reuptake inhibitors (SSRIs) in increasing the risk of malformations, neonatal withdrawal syndrome, has been suggested recently. Here, we aimed to investigate the contribution of individual pharmacogenetics of SSRI on infants' outcome. We also estimated the umbilical/maternal plasma SSRI concentration ratio in the pregnant women still on SSRI therapy at the time of delivery. Methods: Thirty-four pregnant women, referred to our hospital from January 2011 to July 2015, who were given SSRIs in the third trimester, and related children, were considered. The umbilical/maternal plasma SSRI concentration ratio was estimated in 15 mothers still on SSRI therapy at the time of delivery. For patients with pharmacokinetic analyses, blood samples were collected for pharmacogenetic analyses. Results: Nineteen newborns presented clinical signs possibly related to drug toxicity. A high umbilical/maternal plasma ratio of SSRI was observed in 10 of the 15 evaluated newborns. Five mothers were intermediate metabolizers and 1 a poor metabolizer for the major CYP enzyme involved in pharmacokinetic pathway. Conclusions: Individualized psychopharmacologic treatment that takes into account the mother's exposure to SSRI concentrations and eventually her genetic background may become the standard of care to maximize drug benefit and minimize risks to the newborn.
A Quick Guide to Large-Scale Genomic Data Mining

For the first several hundred years of research in cellular biology, the main bottleneck to scientific progress was data collection. Our newfound data-richness, however, has shifted this bottleneck from collection to analysis [1]. While a variety of options exists for examining any one experimental dataset, we are still discovering what new biological questions can be answered by mining thousands of genomic datasets in tandem, potentially spanning different molecular activities, technological platforms, and model organisms. As an analogy, consider the difference between searching one document for a keyword and executing an online search. While the tasks are conceptually similar, they require vastly different underlying methodologies, and they have correspondingly large differences in their potentials for knowledge discovery. Large-scale genomic data mining is thus the process of using many (potentially diverse) datasets, often from public repositories, to address a specific biological question. Statistical meta-analyses are an excellent example, in which many experimental results are examined in order to lend statistical power to a hypothesis test (e.g., for differential expression) [2], [3]. As the amount of available genomic data grows, however, exploratory methods allowing hypothesis generation are also becoming more prevalent. The ArrayExpress Gene Expression Atlas, for example, allows users to examine hundreds of experimental factors across thousands of independent experimental results [4]. In most cases, though, an investigator with a specific question in mind must collect relevant data to bring to bear on a question of interest. Some examples might be: If you've obtained a gene set of interest, in which tissues or cell lines are they coexpressed? If you assay a particular cellular environment, are there other experimental conditions that incur a similar genomic response? If you have high-specificity, low-throughput data for a few genes, with what other genes do they interact or coexpress in high-throughput data repositories? Under what experimental conditions, or in which tissues? Bringing large quantities of genomic data to bear on such questions involves three main tasks: establishing methodology for efficiently querying large data collections; assembling data from appropriate repositories; and integrating information from a variety of experimental data types. Since the technical [5]–[7] and methodological [8]–[10] challenges in heterogeneous data integration have been discussed elsewhere, this introduction will focus mainly on the first two points. As discussed below, the computational requirements for processing thousands of whole-genome datasets in a reasonable amount of time must be addressed, either algorithmically or using cloud or distributed computing [11], [12]. Subsequently, data collection is sometimes easy—as is increasingly the case for high-throughput sequencing, individual experiments can themselves be the sources of large data repositories. In other cases, a biological investigation might benefit from the inclusion of substantial external or public data.
Analysis of small nucleolar RNAs in sputum for lung cancer diagnosis

Molecular analysis of sputum presents a noninvasive approach for diagnosis of lung cancer. We have shown that dysregulation of small nucleolar RNAs (snoRNAs) plays a vital role in lung tumorigenesis. We have also identified six snoRNAs whose changes are associated with lung cancer. Here we investigated if analysis of the snoRNAs in sputum could provide a potential tool for diagnosis of lung cancer. Using qRT-PCR, we determined expressions of the six snoRNAs in sputum of a training set of 59 lung cancer patients and 61 cancer-free smokers to develop a biomarker panel, which was validated in a testing set of 67 lung cancer patients and 69 cancer-free smokers for the diagnostic performance. The snoRNAs were robustly measurable in sputum. In the training set, a panel of two snoRNA biomarkers (snoRD66 and snoRD78) was developed, producing 74.58% sensitivity and 83.61% specificity for identifying lung cancer. The snoRNA biomarkers had a significantly higher sensitivity (74.58%) compared with sputum cytology (45.76%) (P < 0.05). The changes of the snoRNAs were not associated with stage and histology of lung cancer (All P >0.05). The performance of the biomarker panel was confirmed in the testing cohort. We report for the first time that sputum snoRNA biomarkers might be useful to improve diagnosis of lung cancer.
FLAGIDA‐lite is an effective regimen for patients between 70 and 80 years with acute myeloid leukemia or refractory anemia with excess blasts‐2 and is feasible as outpatient treatment

We investigated a FLAGIDA‐lite protocol (fludarabine 40 mg/m2/d orally days 1–5, cytarabine 20 mg/m2/d subcutaneously days 1–5, G‐CSF 300 μg/d subcutaneously days 1–5, and idarrubicin 15 mg/m2/d orally days 1–3) in 38 consecutive patients older than 70 years of age with acute myeloid leukemia (32 patients) or refractory anemia with excess blasts‐2 (six patients) and no prior therapy. Seventy‐nine percent had intermediate/unfavorable karyotype and 79% had a high comorbidity. Overall response was 55% [complete response (CR) 47%] and 37% were refractory. CR rate was 52% in patients between 71 and 79 years of age and 38% in patients 80 years or older. The 4‐week induction mortality was 16% (8% in patients between 70 and 79 years of age and 32% in patients 80 years or older). Overall survival (OS) at 3 years was 22% (31.3% in patients between 70 and 79 years and 15.4% in patients 80 years or older). Relapse‐free survival (RFS) at 3 years was 15%. A total of 65 cycles (47 as induction and 18 as consolidation) were administered, 46 of them (70%) in an outpatient setting. In summary, this FLAGIDA‐lite protocol is an effective and well‐tolerated option for patients between the ages of 70 and 79 years with acute myeloid leukemia or refractory anemia with excess blasts‐2 and is usually feasible as outpatient treatment, but is not beneficial for most patients 80 years or older. Am. J. Hematol. , 2012. © 2011 Wiley Periodicals, Inc.
Improved Semi-Deterministic Scheme to Generate Limited Scale-Free Networks

In this paper, we consider the problem of constructing scale-free networks in a semi-deterministic manner. Scale-free networks have several favorable properties as the topology of interconnection networks such as the short diameter and the quick message propagation. The proposed algorithm is an extension of the Bulut's algorithm for constructing scale-free networks with designated minimum degree k and maximum degree m, such that: 1) it determines the ideal number of edges derived from the ideal degree distribution, and 2) after connecting each new node to k existing nodes as in the Bulut's algorithm, it adjusts the number of edges to the ideal value by conducting add/removal of edges. We prove that such an adjustment is always possible if the number of nodes in the network exceeds m2/k+m.
Traditional Chinese Values and Attitudes of Chinese University Students toward People with Intellectual Disabilities

The purpose of the study was to explore relationships between traditional Chinese values and attitudes toward people with intellectual disabilities. A total of 534 college students in China participated in the study. Two instruments that measure Chinese values and attitudes toward people with intellectual disabilities were used. Results indicated that the value of cultivation of virtues (benevolence, humanity, and a sense of justice) was positively related to attitudes toward people with intellectual disabilities; and that the values of social traditionalism and cultural inwardness (cultural superiority and intolerance) were negatively correlated with attitudes toward people with intellectual disabilities. Additionally, university students majoring in special education or with more knowledge of disabilities had more favourable attitudes toward people with intellectual disabilities than university students majoring in regular education or with little knowledge of disabilities. Implications of the findings are discussed in the context of socio‐economic environments in China.
Ergometric exercise testing and sensitivity of cyclic guanosine 3',5'-monophosphate (cGMP) in diagnosing asymptomatic left ventricular dysfunction.

OBJECTIVE--Increased plasma concentrations of cyclic guanosine monophosphate (cGMP) have been reported in patients with manifest heart failure. At rest, however, cGMP concentrations in patients with asymptomatic left ventricular dysfunction or heart failure in New York Heart Association (NYHA) functional class I do not differ significantly from those of healthy subjects. The purpose of this study was to investigate whether graded exercise on an ergometer improves the sensitivity of cGMP in diagnosing asymptomatic left ventricular dysfunction. PATIENTS--Plasma cGMP concentrations were compared in 17 healthy controls and 98 patients with asymptomatic left ventricular dysfunction or congestive heart failure of different stages (asymptomatic left ventricular dysfunction or NYHA functional class I, 56 patients; NYHA class II, 31 patients; NYHA class III, 11 patients). RESULTS--Before exercise plasma cGMP concentrations in patients with clinical heart failure (NYHA functional classes II and III) were significantly higher than those in healthy controls. In patients with asymptomatic left ventricular dysfunction or heart failure of functional class I plasma cGMP concentrations were not significantly different from those in healthy subjects. Thirty minutes after exercise, however, cGMP concentrations in patients with asymptomatic left ventricular dysfunction or class I heart failure were significantly higher than those in healthy controls. CONCLUSION--Measurement of plasma cGMP concentrations 30 minutes after ergometric exercise testing allows better discrimination between healthy subjects and patients with symptomless left ventricular dysfunction or mild heart failure (NYHA class I) than measurement of such concentrations before exercise.
An Innovative Framework for Integrated Space-Ground Monitoring

The paper presents main results received within the project 'Integrated Intelligent Platform for Monitoring the Cross-Border Natural-Technological systems' (INFROM) in the area of integrated monitoring of complex systems, which contain natural, technological and social elements, based on heterogeneous data received from space and ground-based information sources. An integrated conceptual framework for monitoring as well as technologies supporting information processing, crowd sourcing and integration, process modeling and simulation, and visualization of modeling results are described. Monitoring facilities and support tools are considered as well. The demonstration case and real-time experiments for a short-term flooding forecast are described in the paper.
Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics

Transport of macromolecules across the blood-brain-barrier (BBB) requires both specific and nonspecific interactions between macromolecules and proteins/receptors expressed on the luminal and/or the abluminal surfaces of the brain capillary endothelial cells. Endocytosis and transcytosis play important roles in the distribution of macromolecules. Due to the tight junction of BBB, brain delivery of traditional therapeutic proteins with large molecular weight is generally not possible. There are multiple pathways through which macromolecules can be taken up into cells through both specific and nonspecific interactions with proteins/receptors on the cell surface. This review is focused on the current knowledge of receptor-mediated endocytosis/transcytosis and brain delivery using the Angiopep-2-conjugated system and the molecular Trojan horses. In addition, the role of neonatal Fc receptor (FcRn) in regulating the efflux of Immunoglobulin G (IgG) from brain to blood, and approaches to improve the pharmacokinetics of therapeutic biologics by generating Fc fusion proteins, and increasing the pH dependent binding affinity between Fc and FcRn, are discussed.
FS-SDS: Feature selection for JPEG steganalysis using stochastic diffusion search

Feature extraction and classification based on feature sets are two major components of steganalysis process. The high dimension of feature sets used for steganalysis makes classification a complex and time-consuming process. This paper proposes a novel feature selection algorithm (FS-SDS) for steganalysis. FS-SDS is a wrapper-type feature selection algorithm which selects reduced feature set using Stochastic Diffusion Search. The Stochastic Diffusion Search is a generic population-based search method, which has been adopted successfully in this work for steganalytic feature selection. The experiments are conducted with steganograms of the common JPEG steganography techniques. To show the usefulness and effectiveness of FS-SDS, experiments were conducted on two different feature sets used for steganalysis. The experimental results show that the proposed feature selection not only effectively reduces the dimensionality of the features, but also improves the detection accuracy of the steganalysis process.