Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Service Factors in the Model of Public Transport Mode: A Banjarmasin - Banjarbaru Route Case Study

This research is aimed to examine the extent to which the service factors will affect the probability of people choice on public transports offered. The service factors are essential since the habits in the planning of new public transport at developing cities tend to prioritizes “travel time” and “travel cost” only. Consequently, there will be more than a small number of new public transports that will meet the same fate as the previous ones, i.e. unable to attract the users’ interest. The research is focused on Banjarmasin City and Banjarbaru City which are two administrative cities with high development level and are large generation/attraction zones in South Borneo. The tendency of the use of private vehicles remains high with one of the reasons is the level of transportation services which are still low. Therefore, the planning of new alternative transports (bus) is required, in addition to the existing Paratransit transportation (mikrolet/Indonesian minibus). To obtain a utility and probability model of the of travelers (users) in selecting the public transport modes between the existing transports and new bus alternative transports, the Logit method approach was used and the data were collected by using Stated Preference technique. From the result of this research, the model of mode choice is obtained by including service factors showing the improvement of goodness of fit model, and is compared by those without including service factors. The average of service effect on the increase in the choice probability of the services is 22%, both in the sensitivity of the travel time and travel costs.
SNARE protein FgVam7 controls growth, asexual and sexual development, and plant infection in Fusarium graminearum.

Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins play critical and conserved roles in membrane fusion and vesicle transport of eukaryotic cells. Previous studies have shown that various homologues of SNARE proteins are also important in the infection of host plants by pathogenic fungi. Here, we report the characterization of a SNARE homologue, FgVam7, from Fusarium graminearum that causes head blight in wheat and barley worldwide. Phylogenetic analysis and domain comparison reveal that FgVam7 is homologous to Vam7 proteins of Saccharomyces cerevisiae (ScVam7), Magnaporthe oryzae (MoVam7) and several additional fungi by containing a PhoX homology (PX) domain and a SNARE domain. We show that FgVam7 plays a regulatory role in cellular differentiation and virulence in F. graminearum. Deletion of FgVAM7 significantly reduces vegetative growth, conidiation and conidial germination, sexual reproduction and virulence. The ΔFgvam7 mutant also exhibits a defect in vacuolar maintenance and delayed endocytosis. Moreover, the ΔFgvam7 mutant is insensitive to salt and osmotic stresses, and hypersensitive to cell wall stressors. Further characterization of FgVam7 domains indicate that the PX and SNARE domains are conserved in controlling Vam7 protein localization and function, respectively. Finally, FgVam7 has been shown to positively regulate the expression of several deoxynivalenol (DON) biosynthesis genes TRI5, TRI6 and TRI101, and DON production. Our studies provide evidence for SNARE proteins as an additional means of regulatory mechanisms that govern growth, differentiation and virulence of pathogenic fungi.
Online generation of velocity fields for passive contour following

A new approach to online generation of velocity fields for parametric curves is presented for implementation in passive velocity field controllers (PVFC) that enable human-in-the-loop contour following tasks. In particular, a feedback stabilized closest point tracking algorithm is utilized for real-time determination of the contour error and online construction of the velocity field. The algorithm augments the system dynamics with a new state, and implements a uniformly asymptotically stable controller to update this new state to continual track the closest point to the robot end-effector. Thanks to its feedback-stabilized core, the algorithm is immune to initialization errors, and robust against drift and numerical noise. Furthermore, requiring simple evaluations of the curve and its unit tangents, the approach is computationally efficient. Applicability and effectiveness of the approach to implement passive contour following tasks have been demonstrated through simulations and experiments with a two degrees-of-freedom haptic interface.
A Framework for Language Model Adaptation for Highly-Inflected Slovenian Language

This paper describes a new framework to construct topicadapted language models for large vocabulary speech recognition of highly-inflected Slovenian language. Two important difficulties of high inflectionality in Slovenian language are discussed, out-of-vocabulary rate and feature extraction for topic detection. To use the most popular language models (N-grams) and the well-known classifiers (TFIDF, naive Bayes) effectively, we define different basic units at different stages of language model construction. Basic language models use smaller lexical units. Words are decomposed into stems and endings. In contrast, classifiers require larger units, having semantic information. Words with the same meaning, but different grammatical form, are mapped into a set of equivalence classes. The proposed techniques for basic units selection are language independent. They can be applied to other languages, where words are formed by many different inflectional affixatation. Experimental results of adaptation obtained on the corpus of documents of the second largest Slovenian newspaper Ve čer show the additional 5% improvement in perplexity over basic morphological models.
Regulation of the Human Chorionic Gonadotropin α- and β-Subunit Promoters by AP-2*

Production of the placental hormone, chorionic gonadotropin (CG), increases dramatically as cytotrophoblasts fuse to form syncytiotrophoblasts. The CG α- and β-promoters are both responsive to cAMP, although the kinetics of cAMP stimulation are different. In an effort to understand the mechanisms of coordinate induction of these genes, AP-2 binding sites were identified in the promoter regions of the α and CGβ genes. AP-2 bound to the upstream regulatory element (−186 to −156 base pairs (bp)) in the α-promoter and to several different regions of the CGβ promoter, including footprints 2 and 4B (FP2, −311 to −279 bp; FP4B, 221 to −200 bp). AP-2 antibodies induced supershifts of these complexes, confirming the identity of the protein-DNA complex. In JEG-3 cells, which contain abundant AP-2, mutations in these CGβ AP-2 sites reduced basal activity and decreased cAMP stimulation. In AP-2-deficient Hep-G2 cells, co-transfection of AP-2 stimulated expression of the CGβ promoter 10–20-fold, and the α-promoter was induced by 3–6-fold. Mutations that eliminate AP-2 binding to CGβ FP4B reduced AP-2 stimulation by more than 80%, whereas mutations in FP2 reduced AP-2 stimulation by less than 50%. Analyses of AP-2 mutants revealed a requirement for the DNA binding/dimerization domain and the amino-terminal proline-rich and acid-rich transactivation domains for stimulation of the CGβ promoter. Primary cultures of placental cytotrophoblasts were differentiated into syncytiotrophoblasts in vitro to examine AP-2 expression by reverse transcriptase-polymerase chain reaction. AP-2 mRNA levels increased by day 2 and continued to rise in parallel with a marked increase in α and CGβ gene expression. We conclude that both the α and CGβ promoters contain binding sites for AP-2 and suggest that this transcription factor provides a mechanism for coordinating the induction of these genes during placental cell differentiation.
Anxiety symptoms and behavioural inhibition in young south african children: a follow-up on parent and teacher reports

The present study is a first follow-up assessment by means of parent and teacher reports in a cohort study conducted by Wege (2014). The study examined the long-term relationship between anxiety symptoms and behavioural inhibition in young South African children with the inclusion of parental overprotection as a moderator variable. The aims of the study were to determine whether the relationship between the anxiety symptoms and behavioural inhibition profiles of the 2012 cohort of young South African children changed within a one year follow-up period, while simultaneously assessing the role of parental overprotection. Parent and teacher reports included a Biographical Questionnaire for Parents, the Behavioural Inhibition Questionnaire, the Revised Preschool Anxiety Scale, and, the Parental Overprotection Measure. A total of 59 children of who 25 were female and 34 male were reported on. They were 3 years old (n = 3), 4 years old (n = 16), 5 years old (n = 22), 6 years old (n = 14) and 7 years old (n = 4). In keeping with previous findings, a positive correlation remained between anxiety symptoms and behavioural inhibition, even after one year. The moderating effect of parental overprotection was less strong than predicted. Nonetheless, a non-significant trend in the hypothesised direction was found: the relationship between behavioural inhibition and anxiety was strongest when simultaneously there were high levels of parental overprotection. The only significant difference found between scores of the initial study and that of the present research was that parents reported significantly lower levels of behavioural inhibition at the one year follow-up. Although at a non-significant level, both parent and teacher reports of anxiety indicated higher levels of anxiety at the year follow-up. Results need to be interpreted with caution in view of the smaller number of participants in the cohort study. Stellenbosch University https://scholar.sun.ac.za
Active-Matrix Liquid Crystal Displays - Operation, Electronics and Analog Circuits Design

For more than four decades, Cathode Ray Tube (CRT) Displays have been the dominant display technology providing very attractive performance. Brightness, contrast ratio, high image quality, speed and resolution were the main high standard specifications that CRTs were satisfied. The last two decades, there was a tremendous growth in small portable applications which required the necessary adjustment of the display technology to them. The large depth of the CRTs was the main disadvantage for preventing them to be used in these kinds of applications. Flat Panel Displays seem to be the most attractive solution to this problem. Displays engineers searched for many years in order to find the suitable flat panel display technologies that could replace CRT displays. The first successfully established flat panel technology was the plasma displays, which demonstrated to be of larger size and higher image quality compared to the CRT technology. However, the problem with the integration of plasma displays in small portable applications still exists. Finally, the inroad of the thinfilm transistors liquid crystal displays (TFT-LCD), in late 1990’s, was a milestone in the displays industry and technology. The successful development of the TFT-LCDs was achieved not accidentally. It was the sequence of the liquid crystal cell technology development, in combination with the development of semiconductors technologies for large-area microelectronics on glass, like thin-film transistors. Although, both technologies were very-well known before the 90’s, an extended research for establishing compatible fabrication processes for the materials and the manufacturing equipment has led to the TFT-LCDs realization. TFT-LCDs were rapidly grown and dominated the displays industry, especially in small portable applications. The implementation of the TFT-LCD panel peripheral driving components with low-power CMOS blocks and, therefore, the compatibility with battery operation was the main reason for the ascendance of the TFT-LCD technology in small portable applications. Today, the TFT-LCD market has been expanded. They can be used in an extremely wide range of our everyday life products, like mobile phone applications, ATMs, PDAs, navigation systems, notebook PCs and home applications, such as wide screen TVs. O pe n A cc es s D at ab as e w w w . in te ch w eb . o rg
Classification of all putative permeases and other membrane multispanners of the Major Facilitator Superfamily encoded by the complete genome of Saccharomyces cerevisiae

On the basis of the complete genome sequence of the budding yeast Saccharomyces cerevisiae, a computer-aided analysis was carried out of all members of the major facilitator superfamily (MFS), which typically consists of permeases with 12 transmembrane spans. Analysis of all 5885 predicted open reading frames identified 186 potential MFS proteins. Binary sequence comparison made it possible to cluster 149 of them into 23 families. Putative permease functions could be assigned to 12 families, the largest including sugar, amino acid, and multidrug transport. Phylogenetic clustering of proteins allowed us to predict a possible permease function for a total of 119 proteins. Multiple sequence alignments were made for all families, and evolutionary trees were constructed for families with at least four members. The latter resulted in the identification of 21 subclusters with presumably tightly related permease function. No functional clues were predicted for a total of 41 clustered or unclustered proteins.
A trs20 Mutation That Mimics an SEDT‐Causing Mutation Blocks Selective and Non‐Selective Autophagy: A Model for TRAPP III Organization

TRAPP is a multisubunit complex that functions in membrane traffic. Mutations in the mammalian TRAPP protein C2 are linked to the skeletal disorder spondyloepiphyseal dysplasia tarda (SEDT) that is thought to arise from an inability to secrete procollagen from the endoplasmic reticulum. Here, we show that C2 binds to the SNARE protein Syntaxin 5 and this interaction is weakened by an SEDT‐causing missense mutation (D47Y). Interestingly, the equivalent mutation (D46Y) in the yeast C2 homolog Trs20p does not block anterograde traffic but did affect endocytosis. The trs20D46Y mutation interfered with the interaction between Trs20p and Trs85p (TRAPP III‐specific subunit), Trs120p and Trs130p (TRAPP II‐specific subunits). Size exclusion chromatography suggested that this yeast mutation destabilized the TRAPP III complex that is involved in autophagy. We further show that this mutation blocks both the selective cytosol‐to‐vacuole (cvt) pathway as well as non‐selective autophagy. We demonstrate that the apparent molecular size of the TRAPP III complex is dependent upon membranes, and that the presence of TRAPP III is dependent upon Atg9p. Finally, we demonstrate that lipidated Bet3p is enriched in TRAPP III and that lipidation increases the efficiency of autophagy. Our study suggests that Trs20p acts as an adaptor for Trs85p and Trs120p and reveals complexities in TRAPP III assembly and function. The implications of C2D47Y in SEDT are discussed.
Activity of fludarabine in previously treated Waldenström's macroglobulinemia: a report of 71 cases. Groupe Coopératif Macroglobulinémie.

PURPOSE There is no consensus on the treatment of patients with Waldenström's macroglobulinemia (WM) who develop primary or secondary resistance to frontline therapies. We report our experience on the activity and toxicity of fludarabine in 71 patients with WM resistant to prior chemotherapy regimens. PATIENTS AND METHODS From January 1991 to June 1995, 71 patients were included in this retrospective study. The median age, median time from diagnosis to treatment, median immunoglobulin M (IgM) level, and median number of previous treatments were 68 years (range, 42 to 81), 5.9 years (range, 0.6 to 20), 35 g/L (range, 5 to 126), and two (range, one to four), respectively. RESULTS Seventy-one patients received a median of six courses of fludarabine. Twenty-one (30%) responded with a partial response and 50 (70%) were considered as treatment failures. Forty-six patients died: 10 in the responder group and 36 in the failure group. Twenty-five patients were alive with a median follow-up time of 34 months. The overall median survival time of all treated patients was 23 months. The time to treatment failure was 32 months. The only factor that favorably influenced the response to fludarabine was a longer interval between the first treatment and the start of fludarabine. Pretreatment factors associated with shorter survival in the entire population were hemoglobin level less than 95 g/L (P = .02) and platelet count less than 75 x 10(9)/L (P = .02). CONCLUSION The responses rate in this population with a poor prognosis is close to that reported in shorter series. Patients with WM who are resistant to alkylating agents should be identified early, so that salvage therapy with nucleoside analogs can be started without delay.
Fault Detection for IGBT Using Adaptive Thresholds During the Turn-on Transient

This paper presents the analysis and design of an electronic failure detection system applied to the insulated gate bipolar transistor (IGBT), this proposal is based on the direct measurement of behavior of the gate signal during the turn-on transient. The failures by short-circuit and open-circuit devices only are considered in this paper. To achieve early detection, the IGBT gate signal behavior during turn-on transient is used and to increase the effectiveness of the detection and to tolerate the variations of input to system, adaptable thresholds have been added to the analog electronics circuit implemented. The experimental tests are presented in order to validate the proposed fault-detection technique.
High Dimensional Finite Elements for Elliptic Problems with Multiple Scales and Stochastic Data

Multiple scale homogenization problems are reduced to single scale prob­ lems in higher dimension. It is shown that sparse tensor product Finite Ele­ ment Methods (FEM) allow the numerical solution in complexity independent of the dimension and of the length scale. Problems with stochastic input data are reformulated as high dimensional deterministic problems for the statistical moments of the random solution. Sparse tensor product FEM give a deter­ ministic solution algorithm of log-linear complexity for statistical moments.
Modeling and design of GaAs traveling-wave electrooptic modulators based on capacitively loaded coplanar strips

GaAs traveling-wave electrooptic (EO) modulators based on capacitively loaded coplanar strips (CPSs) have been extensively modeled, and near-optimal designs are presented. The modulator operates in a push-pull mode, and the electrodes are coupled capacitively in series via the doped under layer. The best design reported herein has asymmetric CPSs 2 cm long and generated a figure of merit of about 9.36 GHz/V. This figure of merit is an improvement by a factor of about 2.5 over the best design reported to date for this modulator architecture. Modulator bandwidths in the range of 40-70 GHz (3 dB electrical) are predicted for various designs; the corresponding optical bandwidths are in the range of 75-110 GHz (3 dB optical).
Handbook of Multimethod Measurement in Psychology

Handbook of Multimethod Measurement in Psychology is the first integrative guide to theoretical, methodological, and applied aspects of multimethod measurement in psychological research. Although the multitrait-multimethod analysis and multimethod research strategies have become increasingly important in all areas of psychological research, comprehensible handbooks of multimethod measurement that integrate all phases of the data-gathering and assessment process have been missing. "Handbook of Multimethod Measurement in Psychology" fills this long-standing gap. Researchers and students of research who want to run a multimethod study or who want to understand a published study no longer must page through methodological journals trying to piece together an understanding of multimethod approaches. This volume provides a single, understandable resource for learning the meaning, advantages, and limitations of different methods. The volume brings together outstanding researchers from all areas of psychology. Contributors give detailed explanations about exactly what has to be considered when conducting a multimethod study, what the strength of the convergent validity and method-specificity in different areas of research is, and what methods should be selected for proving validity in specific research contexts. The volume discusses theoretical concepts, then lays out the most important measurement tools - including, among many others, global self-assessment, informant assessment, observational methods, and nonreactive methods - followed by statistical models for analyzing multitrait-multimethod data. Contributors also explore applications of multimethod research in different areas of psychology as well as broader perspectives on the meaning and purpose of multimethod approaches. Destined to be a classic, "Handbook of Multimethod Measurement in Psychology" provides an indispensable resource for researchers and students in psychology seeking to enrich their work by using multimethod approaches.
On sparse possibilistic clustering with crispness — Classification function and sequential extraction

In addition to fuzzy c-means clustering, possibilistic clustering is well-known as one of the useful techniques because it is robust against noise in data. Especially sparse possibilistic clustering is quite different from other possibilistic clustering methods in the point of membership function. We propose a way to induce the crispness in possibilistic clustering by using L1-regularization and show classification function of sparse possibilistic clustering with crispness for understanding allocation rule. We, moreover, show the way of sequential extraction by proposed method. After that, we show the effectiveness of the proposed method through numerical examples.
A Novel Timing and Frequency Synchronization Based on Symmetrical & Conjugate Prefix in OFDM System

A novel timing and frequency synchronization algorithm in OFDM system is proposed, which is based on symmetrical & conjugate prefix, and the expression of likelihood function is presented. Sharp correlation curve of symbol timing can be obtained using the symmetrical and conjugate character of prefix. Simulation shows that the proposed method can achieve a more accurate timing offset estimation and frequency synchronization than that based on cycle prefix.
Using fuzzy undersampling and fuzzy PCA to improve imbalanced classification through Rotation Forest algorithm

This paper proposed a novel undersampling method to reduce the imbalance ratio of a dataset using fuzzy memberships degrees as well as utilizing a new fuzzy principal components analysis (F-PCA) for the classification through Rotation Forest algorithm. In the undersampling phase, first two membership functions are defined on each feature (dimension); one indicates the minority concept and the other shows majority concept. After that, each data sample receives a score based on its membership degrees in each dimension of the feature space. Majority samples with the highest scores are the best candidates of removal. Then during the Rotation Forest algorithm's train phase, a fuzzy Principal Component Analysis (F-PCA) is applied on the fuzzified values of samples which are produced in the undersampling phase. Moreover, these values are used to build the base classifiers of the ensemble. The obtained results illustrate the efficiency and noteworthy high performance of our proposed method comparing to the other state-of-the-art algorithms for class imbalance problem.