Miracle-dz/UniFAR-FTUs huggingface dataset:
c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein

The c-ABL tyrosine kinase is activated following either the loss or mutation of its Src homology domain 3 (SH3), resulting in both increased autophosphorylation and phosphorylation of cellular substrates and cellular transformation. This suggests that the SH3 domain negatively regulates c-ABL kinase activity. For several reasons this regulation is thought to involve a cellular protein that binds to the SH3 domain. Hyperexpression of c-ABL results in an activation of its kinase, the kinase activity of purified c-ABL protein in the absence of cellular proteins is independent of either the presence or absence of a SH3 domain, and point mutations and deletions within the SH3 domain are sufficient to activate c-ABL transforming ability. To identify proteins that interact with the c-ABL SH3 domain, we screened a cDNA library by the yeast two-hybrid system, using the c-ABL SH3SH2 domains as bait. We identified a novel protein, AAP1 (ABL-associated protein 1), that associates with these c-ABL domains and fails to bind to the SH3 domain in the activated oncoprotein BCRABL. Kinase experiments demonstrated that in the presence of AAP1, the ability of c-ABL to phosphorylate either glutathione S-transferase-CRK or enolase was inhibited. In contrast, AAP1 had little effect on the phosphorylation of glutathione S-transferase-CRK by the activated ABL oncoproteins v-ABL and BCRABL. We conclude that AAP1 inhibits c-ABL tyrosine kinase activity but has little effect on the tyrosine kinase activities of oncogenic BCRABL or v-ABL protein and propose that AAP1 functions as a trans regulator of c-ABL kinase. Our data also indicate that loss of susceptibility to AAP1 regulation correlates with oncogenicity of the activated forms of c-ABL.
Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY7201

Objective. In a preclinical, nonhuman primate islet allotransplant model, the authors evaluated a novel immunosuppressive combination of basiliximab for induction and of RAD and FTY720 for maintenance. Methods. Five ABO-compatible and mixed lymphocyte reactivity-mismatched streptozotocin-induced diabetic juvenile cynomolgus monkeys underwent transplantation intraportally with 48-hr cultured 10,000 islet equivalents per kilogram. Induction immunosuppression was with intravenous basiliximab (10 mg on postoperative days 0 and 4). Maintenance immunosuppression was with RAD (everolimus) (0.075 mg/kg per day administered subcutaneously) and FTY720 (0.3 mg/kg per day administered orally), both administered on day −2 through day 180 posttransplant. Results. All five recipients tolerated their transplants and immunosuppressive therapy well, without adverse events or infectious complications. Insulin requirements pretransplant were 2.6 to 4.0 U/kg per day. All recipients became normoglycemic and insulin-independent posttransplant. Posttransplant serum C-peptide levels averaged 2.7 ng/mL (range, 0.6–6.2 ng/mL). Morning blood glucose levels ranged from less than 100 mg/dL to 150 mg/dL. Posttransplant acute C-peptide response to intravenous arginine averaged 1.3 ng/mL (range, 0.23–2.72 ng/mL). In one recipient with subtherapeutic RAD blood levels on day 7 posttransplant, exogenous insulin was resumed 100 days posttransplant; basal C-peptide levels remained positive in this recipient and averaged 2.6 ng/mL. The other four recipients remained insulin-independent for more than 6 months. Conclusions. This study provides preliminary evidence of the safety and efficacy of corticosteroid- and calcineurin inhibitor-free immunosuppression in a relevant preclinical transplant model. These findings provide a strong rationale for evaluating this nondiabetogenic regimen in a clinical trial of islet transplants in type 1 diabetic recipients.
Differentiation of traffic on access networks

The Internet is facing a huge change with the increasing penetration of voice terminals and new P2P overlay networks. These changes hit hardest on access networks which need to cope simultaneously with the new stringent requirements of real-time traffic and with the increased volumes of P2P traffic. These two facts bring an urgent need for differentiation of traffic in access networks - not only downstream but also upstream. The majority of upstream traffic is composed of metafile systems, like BitTorrent and Gnutella, which distribute the file content in an overlay manner to each and every subscriber in the metafile system. This brings new challenges for handling the traffic: i) from the user perspective, co-operation within the overlay community, but still controlling the resource usage; ii) from the network provider perspective, minimal waste of scarce access network resources. We show a measurement study of differentiation of IP traffic with the goal of minimizing the delay of real-time traffic and at the same time minimizing the packet loss of P2P traffic. Our results show that proper grouping of traffic is important at both ends of the access-link.
An improved resampling approach for particle filters in tracking

Resampling is an essential step in particle filtering (PF) methods in order to avoid degeneracy. Systematic resampling is one of a number of resampling techniques commonly used due to some of its desirable properties such as ease of implementation and low computational complexity. However, it has a tendency of resampling very low weight particles especially when a large number of resampled particles are required which may affect state estimation. In this paper, we propose an improved version of the systematic resampling technique which addresses this problem and demonstrate performance improvement.
Recommended Screening Strategy for Preventing Tuberculosis Flare in Patients with Inflammatory Rheumatic Diseases Receiving Tumor Necrosis Factor-α Inhibitors in India — Followup Report

To the Editor: We published a strategy for screening of latent tuberculosis infection (LTBI) for prevention of TB flare among patients with inflammatory rheumatic diseases (IRD) receiving tumor necrosis factor-α (TNF-α) inhibitors1. Flare of LTBI has been a serious problem among patients receiving monoclonal antibody-based TNF-α inhibitors in high-burden TB regions of the world, including India. We present results on an additional 33 patients … Address correspondence to Dr. A.N. Malaviya, Flat 2015, Sector B-2, Vasant Kunj, New Delhi, 110070, India; E-mail: anand_malaviya{at}yahoo.com
Optimal adgangsregulering til de videregående uddannelser og elevers valg af fag i gymnasiet

Regeringen har fremlagt et forslag til reform af gymnasiet med det sigte at styrke naturvidenskab. En gennemforelse af forslaget ma imidlertid forventes at formindske andelen af elever i gymnasiet, som folger naturvidenskabelige fag. Dette vises i en simpel modelramme til analyse af elevernes valg af fag i slutningen af gymnasiet. Omfanget af obligatorisk naturvidenskab i begyndelsen af gymnasiet er af sekundaer betydning for udviklingen i rekrutteringsgrundlaget til de videregaende uddannelser med teknisk indhold, idet omfanget af obligatorisk naturvidenskab i gymnasiet ikke er tilstraekkeligt stort til at give grundlag for begynde pa en naturvidenskabeligt uddannelse. Det afgorende er udfaldet af de valg mellem forskellige fagkombinationer, eleverne traeffer i slutningen af gymnasiet. Sammensaetningen af de valgmuligheder, som det besluttes at stille eleverne overfor, er derfor af vaesentlig betydning for studieegnetheden for de kommende gymnasieargange. Indledningsvis gennemfores et bevis for, hvordan adgangsreguleringen til de videregaende uddannelser skal udformes for at minimere frafaldet, og det vises endvidere, hvordan optimal adgangsregulering vil aendre elevernes valg af fag i gymnasiet, sa de bliver bedre til at besta en videregaende uddannelse.
Supercooling and nucleation of silicon after laser melting.

Bulk nucleation of crystalline Si at a supercooling of 505 K was observed following pulsed-laser--induced melting of thin films. If the nucleation was homogeneous, the estimated nucleation rate of 10/sup 29/ eventsm/sup 3/ s implies a liquid-Si--crystalline-Si interfacial energy of 0.45 +- 0.02 Jm/sup 2/. In addition, observation of crystalline nucleation bounds the interface energy between amorphous Si and liquid Si to be >0.20 Jm/sup 2/. This laser melting technique is applicable to nucleation studies in a wide variety of materials.
Cross-Layer Modeling Framework for Energy-Efficient Resilience

Abstract : We describe a novel cross-layer, resilience focused integrated modeling framework. This is targeted to help define ultra energy-efficient embedded systems in the post-14nm CMOS design era, without compromising system-level resilience. The targeted application domain is represented by the suite of applications and kernels announced as part of the ongoing PERFECT program sponsored by DARPA MTO.
The trauma registry as a statewide quality improvement tool.

BACKGROUND Trauma registries have been developed to describe the pattern of trauma and trauma workload, provide data for research, and to demonstrate changes in patient outcomes. Quality improvement using trauma registries at a system-wide level has been difficult to achieve. In Victoria, Australia, a statewide trauma system and trauma registry has been established to monitor and feedback the process of management and outcomes of major trauma patients across all healthcare providers. METHODS The development and implementation of the Victorian State Trauma Registry (VSTR), including its role as a quality monitoring tool and results from the first 2 years of operation, are provided. RESULTS More than 80% of major trauma patients are being managed at major trauma services and standardized death rates are comparable with international standards. Quality indicators identify some areas for improvement. CONCLUSION VSTR data indicate that the statewide trauma system is working well and provides a method for ongoing monitoring and trauma care feedback.
Wormlike Micelles Formed by Synergistic Self-Assembly in Mixtures of Anionic and Cationic Surfactants

Self-assembly in mixtures of cationic and anionic surfactants occurs synergistically because of attractive interactions between the oppositely charged headgroups. Here, such effects are exploited to obtain highly viscoelastic fluids at low total surfactant concentration. The systems considered are mixtures of the C18-tailed anionic surfactant, sodium oleate (NaOA), and cationic surfactants from the trimethylammonium bromide family (CnTAB). In particular, mixtures of NaOA and C8TAB show remarkably high viscosities: for 3% surfactant, the zero-shear viscosity η0 peaks at ca. 1800 Pa·s for a weight ratio of 70/30 NaOA/C8TAB. The high viscosities reflect the growth of giant, entangled wormlike micelles in the solutions. Mixtures of NaOA with a shorter-chain analogue (C6TAB) have much lower viscosities, indicating a weak micellar growth and hence a weak attraction between the surfactants. On the other hand, increasing the CnTAB tail length to n = 10 or 12 leads to much stronger interactions between these surf.
Use of Phase Shifting Transformers for Minimising Congestion Risk

This paper demonstrates a methodology for the optimal use of phase shifting transformers (PSTs) for the minimisation of the risk of congestion on power system lines. The methodology proposes as a first step the use of Monte-Carlo simulation for the assessment of the power flow distributions in the lines. It is shown that by using PSTs these distributions are shifted by specific factors that can be derived from the system topology and the location of the PSTs. In this context, the problem of de-congesting the system corresponds to finding the PST settings that shift these distributions inside the operational limits of the power system lines. This optimisation problem can not be defined by an analytical expression; a simulation-based optimisation is therefore proposed, in particular particle swarm optimisation. A study case shows how the proposed technique leads to the best utilisation of the capacity in a meshed grid.
Reductions in cholesterol and synaptic markers in association cortex in mood disorders.

OBJECTIVES Cholesterol forms an integral part of cell membranes and is a major component of myelin. Furthermore, cholesterol also plays a vital role in the development, function and stability of synapses. While low serum cholesterol has previously been associated with mood disorders, cholesterol levels have yet to be quantified within the brain in these disorders. The aim of this study was to quantify sterol levels in the brains of patients with major psychiatric disorders and further to relate these levels to markers of myelin and synapses. METHODS Samples of visual association cortex were obtained postmortem from subjects with bipolar disorder (BPD), major depressive disorder (MDD) and schizophrenia (SCZ) and from controls (all n = 15). Concentrations of brain cholesterol, its precursors lathosterol, desmosterol and lanosterol and its metabolite 24S-hydroxycholesterol were determined by gas-liquid chromatography. Immunoreactivity for myelin basic protein (MBP), synaptophysin and VAMP was quantified by enzyme-linked immunosorbent assay. RESULTS Cholesterol levels were 13% lower in MDD (p = 0.018) and 10% lower in BPD (p = 0.052) compared with controls. Cholesterol precursor or metabolite concentrations did not differ between groups. Synaptophysin immunoreactivity was 20% lower in BPD (p = 0.025) and VAMP immunoreactivity 37% lower in MDD (p = 0.032) and 45% lower in BPD (p = 0.009). MBP immunoreactivity was not altered in any disorder. CONCLUSIONS Our data suggest that lower brain cholesterol levels and a reduction in synapses may be features of mood disorders.
Le morcellement des exploitations agricoles françaises

Depuis la fin de la Seconde Guerre mondiale, la diminution du nombre des exploitations agricoles francaises et l’augmentation concomitante de leur taille se sont accompagnees d’un important remaniement des parcellaires. Malgre tout, et notamment en depit des differentes mesures specifiquement foncieres de la « politique des structures » mises en place des les annees 1960 (remembrement, amenagement foncier et rural, creation des Societes d’amenagement foncier et d’etablissement rural, Operatio.
Phylogenetic Relationships of Harpyionycterine Megabats ( Chiroptera : Pteropodidae )

After almost 70 years of stability following publication of Andersen’s (1912) monograph on the group, the systematics of megachiropteran bats (Chiroptera: Pteropodidae) was thrown into flux with the advent of molecular phylogenetics in the 1980s—a state where it has remained ever since. One particularly problematic group has been the Austromalayan Harpyionycterinae, currently thought to include Dobsonia and Harpyionycteris, and probably also Aproteles. In this contribution we revisit the systematics of harpyionycterines. We examine historical hypotheses of relationships including the suggestion by O. Thomas (1896) that the rousettine Boneia bidens may be related to Harpyionycteris, and report the results of a series of phylogenetic analyses based on new as well as previously published sequence data from the genes RAG1, RAG2, vWF, c-mos, cytb, 12S, tVal, 16S, and ND2. Despite a striking lack of morphological synapomorphies, results of our combined analyses indicate that Boneia groups with Aproteles, Dobsonia, and Harpyionycteris in a well-supported, expanded Harpyionycterinae. While monophyly of this group is well supported, topological changes within this clade across analyses of different data partitions indicate conflicting phylogenetic signals in the mitochondrial partition. The position of the harpyionycterine clade within the megachiropteran tree remains somewhat uncertain. Nevertheless, biogeographic patterns (vicariance-dispersal events) within Harpyionycterinae appear clear and can be directly linked to major biogeographic boundaries of the Austromalayan region. The new phylogeny of Harpionycterinae also provides a new framework for interpreting aspects of dental evolution in pteropodids (e.g., reduction in the incisor dentition) and allows prediction of roosting habits for Harpyionycteris, whose habits are unknown.
University of Dundee Corpus resources for dispute mediation discourse

Dispute mediation is a growing activity in the resolution of conflicts, and more and more research emerge to enhance and better understand this (until recently) understudied practice. Corpus analyses are necessary to study discourse in this context; yet, little data is available, mainly because of its confidentiality principle. After proposing hints and avenues to acquire transcripts of mediation sessions, this paper presents the Dispute Mediation Corpus, which gathers annotated excerpts of mediation dialogues. Although developed as part of a project on argumentation, it is freely available and the text data can be used by anyone. This first-ever open corpus of mediation interactions can be of interest to scholars studying discourse, but also conflict resolution, argumentation, linguistics, communication, etc. We advocate for using and extending this resource that may be valuable to a large variety of domains of research, particularly those striving to enhance the study of the rapidly growing activity of dispute mediation.
Body weight distributions of central European Coleoptera

Species number - body weight distributions are generally thought to be skewed to the right. While this pattern is well documented in vertebrates, comparative studies on species rich invertebrate taxa are still scarce. Here I show that the weight distribu- tions of central European Coleoptera (based on 8257 species body weight data compiled from Freude et al., 1964-1994) are pre- dominantly right skewed. Skewness and species richness per taxon were positively correlated. The number of modes of the body weight distributions was negatively correlated with species richness. 273 of the 558 genera had bimodal distributions. Species rich- ness per genus did not significantly depend on mean genus body weight. In general the coleopteran size distributions differed from those of European Hymenoptera but were similar to the respective distributions of vertebrates. I conclude that we should be cautious when generalizing patterns found in one taxon.
The OSA project: an example of component based software engineering techniques applied to simulation

In this paper I manage to give a global and comprehensive overview on the Open Simulation Architecture project (OSA). OSA is an open software platform that aims at supporting empirical studies based on discrete-event simulations. The underlying philosophy of OSA is to exploit and apply everywhere it is possible the latest relevant Component-Based Software Engineering (CBSE) techniques, in order to ease reuse of existing or new simulation software and models. In this paper we show how these techniques may be applied at several levels (Architecture, Simulation Engine, Modeling API and Simulation Engine) and with which expected benefits.
Automated system measuring triple oxygen and nitrogen isotope ratios in nitrate using the bacterial method and N2 O decomposition by microwave discharge.

RATIONALE Triple oxygen and nitrogen isotope ratios in nitrate are powerful tools for assessing atmospheric nitrate formation pathways and their contribution to ecosystems. N2 O decomposition using microwave-induced plasma (MIP) has been used only for measurements of oxygen isotopes to date, but it is also possible to measure nitrogen isotopes during the same analytical run. METHODS The main improvements to a previous system are (i) an automated distribution system of nitrate to the bacterial medium, (ii) N2 O separation by gas chromatography before N2 O decomposition using the MIP, (iii) use of a corundum tube for microwave discharge, and (iv) development of an automated system for isotopic measurements. Three nitrate standards with sample sizes of 60, 80, 100, and 120 nmol were measured to investigate the sample size dependence of the isotope measurements. RESULTS The δ17 O, δ18 O, and Δ17 O values increased with increasing sample size, although the δ15 N value showed no significant size dependency. Different calibration slopes and intercepts were obtained with different sample amounts. The slopes and intercepts for the regression lines in different sample amounts were dependent on sample size, indicating that the extent of oxygen exchange is also dependent on sample size. The sample-size-dependent slopes and intercepts were fitted using natural log (ln) regression curves, and the slopes and intercepts can be estimated to apply to any sample size corrections. When using 100 nmol samples, the standard deviations of residuals from the regression lines for this system were 0.5‰, 0.3‰, and 0.1‰, respectively, for the δ18 O, Δ17 O, and δ15 N values, results that are not inferior to those from other systems using gold tube or gold wire. CONCLUSIONS An automated system was developed to measure triple oxygen and nitrogen isotopes in nitrate using N2 O decomposition by MIP. This system enables us to measure both triple oxygen and nitrogen isotopes in nitrate with comparable precision and sample throughput (23 min per sample on average), and minimal manual treatment. Copyright © 2016 John Wiley & Sons, Ltd.
Quantum Transport Simulation of Strain and Orientation Effects in Sub-20 nm Silicon-on-Insulator FinFETs

Quantum confinement in nanoscale MOSFETs based on silicon-on-insulator FinFET architecture will affect the effectiveness of strain engineering. This is because energy valley splitting due to quantum confinement may weaken the strain effect. In this paper, we investigate this phenomenon by an in-house quantum transport simulator, Schrödinger equation Monte Carlo in three dimensions, which can provide the quantum transport simulation of nanoscale 3-D MOSFET geometries such FinFETs, as well as take various scattering processes into account. Our simulation results indicate that the strain effect is more significant for devices with a channel orientation than those with a channel orientation. In addition, we also found that the strain effect is more notable when the scattering effect is considered in the quantum transport simulation. This result indicates that the scattering of hot carriers still plays a role in the carrier transport and, thus, the drain current of the nanoscale MOSFETs.
Decoding of motor intentions from epidural ECoG recordings in severely paralyzed chronic stroke patients

Objective. Recently, there have been several approaches to utilize a brain–computer interface (BCI) for rehabilitation with stroke patients or as an assistive device for the paralyzed. In this study we investigated whether up to seven different hand movement intentions can be decoded from epidural electrocorticography (ECoG) in chronic stroke patients. Approach. In a screening session we recorded epidural ECoG data over the ipsilesional motor cortex from four chronic stroke patients who had no residual hand movement. Data was analyzed offline using a support vector machine (SVM) to decode different movement intentions. Main results. We showed that up to seven hand movement intentions can be decoded with an average accuracy of 61% (chance level 15.6%). When reducing the number of classes, average accuracies up to 88% can be achieved for decoding three different movement intentions. Significance. The findings suggest that ipsilesional epidural ECoG can be used as a viable control signal for BCI-driven neuroprosthesis. Although patients showed no sign of residual hand movement, brain activity at the ipsilesional motor cortex still shows enough intention-related activity to decode different movement intentions with sufficient accuracy.