Miracle-dz/UniFAR-FTUs huggingface dataset:
Contraction-related stimuli regulate GLUT 4 traffic in C 2 C 12-GLUT 4 myc skeletal muscle cells

Wenyan Niu, Philip J. Bilan, Shuhei Ishikura, Jonathan D. Schertzer, Ariel Contreras-Ferrat, Zhengxiang Fu, Jie Liu, Shlomit Boguslavsky, Kevin P. Foley, Zhi Liu, Jinru Li, Guilan Chu, Thomas Panakkezhum, Gary D. Lopaschuk, Sergio Lavandero, Zhi Yao, and Amira Klip Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Immunology, Key Laboratory of Immuno Microenvironment and Disease of the Educational Ministry of China, Tianjin Medical University, Tianjin, China; Centro Estudios Moleculares de la Célula, Facultad Ciencias Quimicas y Farmaceuticas; Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile; and Cardiovascular Research Group, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
Understanding the Factors Influencing the Perception of Organizational Sustainability Among Healthcare Professionals (HCPs) Post the Patient Protection and Affordable Care Act

xii I.INTRODUCTION. 1 Background of the Problem. 1 Statement of the Problem. 6 Purpose of the Study. 7 Variables. 8 Research Questions. 8 Research Hypotheses. 9 Significance of the Study. 32 Operational Definitions. 33 II. LITERATURE REVIEW. 39 What is Organizational Sustainability . 39 Healthcare as a Business. 44 How HCPs View Organizational Sustainability. 46 Practical Tactics for Organization Sustainability. 57 III. METHODOLOGY. 59 Introduction.59
Natural variation in a polyamine transporter determines paraquat tolerance in Arabidopsis

Polyamines (PAs) are ubiquitous, polycationic compounds that are essential for the growth and survival of all organisms. Although the PA-uptake system plays a key role in mammalian cancer and in plant survival, the underlying molecular mechanisms are not well understood. Here, we identified an Arabidopsis L-type amino acid transporter (LAT) family transporter, named RMV1 (resistant to methyl viologen 1), responsible for uptake of PA and its analog paraquat (PQ). The natural variation in PQ tolerance was determined in 22 Arabidopsis thaliana accessions based on the polymorphic variation of RMV1. An RMV1-GFP fusion protein localized to the plasma membrane in transformed cells. The Arabidopsis rmv1 mutant was highly resistant to PQ because of the reduction of PQ uptake activity. Uptake studies indicated that RMV1 mediates proton gradient-driven PQ transport. RMV1 overexpressing plants were hypersensitive to PA and PQ and showed elevated PA/PQ uptake activity, supporting the notion that PQ enters plant cells via a carrier system that inherently functions in PA transport. Furthermore, we demonstrated that polymorphic variation in RMV1 controls PA/PQ uptake activity. Our identification of a molecular entity for PA/PQ uptake and sensitivity provides an important clue for our understanding of the mechanism and biological significance of PA uptake.
Employee Longevity in Difficult Environments

iii Dedication . iv Acknowledgements . v Chapter 1: Introduction to the Problem . 1 Conceptual Framework for the Study . 3 Statement of the Problem . 7 Purpose of the Study . 7 Research Questions. 8 Research Design . 8 Rationale, Relevance, and Significance of the Study . 11 Definition of Terms . 12 Assumptions, Delimitations, and Limitations . 13 Summary . 15 Chapter 2: Literature Review . 17 Conceptual Framework . 19 Literature Review . 23 Factors of Age and Diversity Affecting Longevity . 23 Healthy Workplaces . 25 Employee Engagement . 27 Toxic Environments . 29 Corporate Culture . 32 Free Agents . 34
A composite design for transition from a preliminary to a full‐scale study

In drug development, a sequence of studies are conducted to evaluate effectiveness (or efficacy) and safety, such as a Phase II study to assess pharmacological activity or safety that is then followed by a definitive Phase III study to assess clinical effectiveness. Rather than conducting separate successive studies, we describe a design in which the patients enrolled in a preliminary (e.g. Phase II) study are continued into a subsequent full‐scale (e.g. Phase III) study. This design also applies to a study that uses an internal pilot with a preliminary assessment of efficacy or safety. The combined preliminary to full‐scale design potentially reduces the total numbers of patients required and the total duration of the program. The design allows a futility or safety stopping boundary for the preliminary study result that is specified in terms of a lower critical Z‐value (ZL) and the pursuant type II error probability incurred under a specified alternative hypothesis of a beneficial effect or no toxicity at that stage. This boundary also leads to a deflation of the type I error probability for the final test at the completion of the full‐scale study, such that a critical value for the final test (ZF) can be determined that provides the desired level of the type I error probability exactly. Thus, it is possible to determine sample sizes at the two stages, and critical values ZL and ZF that provide specified type I and II error probabilities for the combined study. We describe the design using large‐sample normally distributed Z‐tests at the two phases, including a test for means, or proportions or survival times, or combinations thereof, such as a test for means at Phase II followed by a test for proportions at Phase III.
Compact bandpass filter based on hybrid spoof surface plasmon and substrate integrated waveguide transmission line

In this paper, spoof surface plasmon polariton (SSPPs) and substrate integrated waveguide (SIW) based bandpass filter is proposed. The metal strip on the top of the substrate is composed of periodic slots which supports surface wave mode of SPP within the closed substrate integrated waveguide. The dispersion relation of the proposed structure shows that it has both low-pass feature of SSP and the high-pass feature of SIW, and hence the combination of these two features leads to a bandpass filter (BPF). The results show that the passband is from 11.5–19 GHz with relative bandwidth of 49%. Bandwidth can be controlled by properly adjusting the parameters of the design. The proposed design features a compact size and easy fabrication, due to the integration of SPP in a closed SIW.
An information System for Food Safety Monitoring in Supply Chains based on HACCP, Blockchain and Internet of Things

With the rapid growth of China's economy, people's living standard has been increased continuously, which changed the consuming habit of consumers, and more and more attention is paid to food safety and quality. However, in recent years, a series of serious food safety incidents occurred, such as "Sudan red", "clenbuterol", "Sanlu toxic milk powder" and "trench oi". It is worth noting that not only in China, but even in Europe these kinds of scandals have broken out during the past 20 years, including Escherichia coliin hamburgers, Salmonella in eggs, poultry and pork, Listeria in pates and cheeses, and the "horse meat scandal" in 2013. These food safety problems not only harm people's health, but also undermine their trust in food markets. The main purpose of this cumulative dissertation is trying to guarantee the food quality and safety from a supply chain management perspective, and the key issue is building a decentralized information system which is not dependent on the trust of a central authority or organization for the whole food supply chain. By using the internet of things and blockchain technologies, this new decentralized information system could become a disruptive innovation which could provide an information platform for all supply chain members (including government departments and third-party regulators) based on openness, transparency, neutrality, reliability and security. We want to establish a food supply chain traceability system for real-time food tracing, build a safety control system for food supply chain by integrating it with general supply chain risk management methods, and significantly improve the performance of the food logistics company. All of these will ultimately enhance the safety assurance of a food supply chain.
Emerging Perspectives on Distinctions Between Romantic Love and Sexual Desire

Although sexual desire and romantic love are often experienced in concert, they are fundamentally distinct subjective experiences with distinct neurobiological substrates. The basis for these distinctions is the evolutionary origin of each type of experience. The processes underlying sexual desire evolved in the context of sexual mating, whereas the processes underlying romantic love—or pair bonding—originally evolved in the context of infant-caregiver attachment. Consequently, not only can humans experience these feelings separately, but an individual's sexual predisposition for the same sex, the other sex, or both sexes may not circumscribe his or her capacity to fall in love with partners of either gender. Also, the role of oxytocin in both love and desire may contribute to the widely observed phenomenon that women report experiencing greater interconnections between love and desire than do men. Because most research on the neurobiological substrates of sexual desire and affectional bonding has been conducted with animals, a key priority for future research is systematic investigation of the coordinated biological, behavioral, cognitive, and emotional processes that shape experiences of love and desire in humans.
The Robustness of the Corporate Social and Financial Performance Relation: A Second‐Order Meta‐Analysis

For many decades, there has been a debate about the relation between corporate social/environmental performance (CSP) and corporate financial performance (CFP). Our study presents a review of academic research on this topic by applying a second-order meta-analysis. The data sample combines 25 previous meta-analyses yielding a sample size of one million observations. Our results demonstrate a highly significant, positive, robust, and bilateral CSP-CFP relation. The relation is positive regardless of whether firms focus on ecological or social aspects, though corporate reputation turns out to be a key CSP determinant. We find a particularly strong CSP-CFP relation for operational CFP. Furthermore, we add a new perspective on potential biases resulting from the studies’ publishing source: social issues-oriented journals and methodological weaker papers do not distort the positive CSP-CFP relation. Our conclusion is: Based on the extant literature, the business case for being a good firm is undeniable. © 2018 The Authors. Corporate Social Responsibility and Environmental Management published by ERP Environment and John Wiley & Sons Ltd. Received 24 April 2017; revised 22 October 2017; accepted 3 November 2017
Povidone‐iodine in experimental peritoneal hydatidosis

The effect of polyvinylpyrrolidone‐iodine (PVP‐I) on experimental peritoneal hydatidosis was evaluated in this randomized blind controlled study. Seventy‐five white, 3‐month‐old rats were subjected to laparotomy. After the intraperitoneal inoculation of viable scolices, the rats were randomly divided into three groups. Their peritoneal cavities were irrigated with either 1 per cent PVP‐I solution (the PVP‐I group), hypertonic saline (the HS group) or Ringer's lactate (the control group). Each group was assigned a separate code number; observers blind to the meaning of the code numbers noted all findings during a period of 4 months, after which the rats were killed to allow assessment of the abdominal cavity. The results were decoded after the statistical analyses were completed. The incidence of peritoneal cysts was found to be lower (8·7 per cent) in the PVP‐I group compared with the HS (50 per cent) and control (90·9 per cent) groups; the mean number of hydatid cysts per animal was also lower in the PVP‐I group compared with the other two groups. We conclude that the scolicidal activity of PVP‐I is significantly higher than that of hypertonic saline and that it can be employed as a prophylactic agent against peritoneal hydatidosis.
A New Concept For Isokinetic Hamstring: Quadriceps Muscle Strength Ratio

Conventionally, the hamstring:quadriceps strength ratio is calculated by dividing the maximal knee flexor (hamstring) moment by the maximal knee extensor (quadriceps) moment measured at identical angular velocity and contraction mode. The agonist-antagonist strength relationship for knee extension and flexion may, however, be better described by the more functional ratios of eccentric hamstring to concentric quadriceps moments (extension), and concentric hamstring to eccentric quadriceps moments (flexion). We compared functional and conventional isokinetic hamstring: quadriceps strength ratios and examined their relation to knee joint angle and joint angular velocity. Peak and angle-specific (50°, 40°, and 30° of knee flexion) moments were determined during maximal concentric and eccentric muscle contractions (10° to 90° of motion; 30 and 240 deg/sec). Across movement speeds and contraction modes the functional ratios for different moments varied between 0.3 and 1.0 (peak and 50°), 0.4 and 1.1 (40°), and 0.4 and 1.4 (30°). In contrast, conventional hamstring:quadriceps ratios were 0.5 to 0.6 based on peak and 50° moments, 0.6 to 0.7 based on 40° moment, and 0.6 to 0.8 based on 30° moment. The functional hamstring:quadriceps ratio for fast knee extension yielded a 1:1 relationship, which increased with extended knee joint position, indicating a significant capacity of the hamstring muscles to provide dynamic knee joint stability in these conditions. The evaluation of knee joint function by use of isokinetic dynamometry should comprise data on functional and conventional hamstring:quadriceps ratios as well as data on absolute muscle strength.
Low‐dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human neoplasms with extremely poor prognosis and a low survival rate. Immunosuppressive cell populations, e.g. regulatory T cells (Treg), appear to be important in PDAC, contributing to patient's poor prognosis. Therefore, we investigated the PDAC microenvironment with a focus on conventional and regulatory T cells in view of their potential therapeutic importance. We found that tumors from the murine Panc02 orthotopic model of PDAC were infiltrated with high numbers of Treg. Remarkably, these cells exhibited the effector/memory phenotype, suggesting their enhanced suppressive activity and higher proliferation capacity. Although we observed a steady increase in transforming growth factor‐β (TGF‐β) levels in the tumors, treatment with a specific inhibitor of TGF‐β receptor I kinase failed to abrogate Treg accumulation. A CCR4 antagonist did not affect Treg percentage in the tumor either. However, intense Treg cell division in the tumor microenvironment was demonstrated, suggesting local proliferation as a major mechanism of Treg accumulation in PDAC. Notably, this accumulation was reduced by low‐dose gemcitabine administration, resulting in a modestly increased survival of PDAC mice. Our results provide an insight into mechanisms of immunosuppression in PDAC, suggesting an important role for proliferative expansion of effector/memory Treg. Low‐dose gemcitabine therapy selectively depletes Treg, providing a basis for new modalities of PDAC therapy.
The Diversity Of Waqf Implementations for Economic Development in Higher Education

ABSTRACTThe development of higher education in Malaysia is multiplying based on the increasing numbers of Public Higher Learning Institutions (IPTA) and Private Higher Learning Institutions (IPTS). This increase has encouraged various parties to collaborate to create a solid foundation and strategy to create IPT to become more competitive. However, the funding factor is still one restraint that IPTs must face. To overcome this problem, one example of IPT is taking the initiative by implementing waqf for higher education in limited institutions. Based on this scenario, the present paper was written to achieve two objectives:The first isto examine the precise development of higher education waqf that has been implemented in IPT in Malaysia. Thesecond isto precisely examine the variety of waqf that can be implemented for higher education. This study is an exploration in which the data used were derived from library research. The findings of this study will develop a theory on the diversification of waqf implementations for higher education in Malaysia. Keywords: Diversity, Economic, Instrument of Waqf, Waqf of Higher Education
Home network development based on CORBA middleware

In this paper we propose a home network infrastructure based on CORBA middleware in order to enable the connection and integration of multiple home devices by giving communication, control, monitoring, and management services. The home network's connections and services are developed based on the CORBA event channel using client-server configuration. Several functions are developed in the home network such as; remote controlling, remote monitoring, manual or automatic device configuration and devices management. Several services and functions are provided to examine the network performance. The proposed design is evaluated using a testbed based on the PLC Ethernet and Wi-Fi communication media. Finally, network connection from small number of clients until one hundred clients also has been simulated to observe the overall performance.
Constructing Flow-Based Tools with Generative and Compositional Techniques

In this paper, a model called object-oriented attribute grammar (OOAG), which combines both compositional and generative techniques, is presented to effectively construct flow-based tools that deal with fine-grained language semantics as well as a mass of graphics-drawing activities. OOAG, which consists of two interrelated parts: a model-view-shape (MVS) class framework and an AG++, an object-oriented extension to traditional AGs, is intended to preserve both advantages introduced by respective OO and AG models, such as rapid prototyping, reusability, extensibility, incrementality, and applicability. So far, a flow-based editor associated with two flow-analyzer prototypes, DU/UD tools and a program slicer, have been implemented using OOAG on the Windows environment. Our flow-based editor can be used to construct programs by specifying the associated flow information in a visual way, while (incremental) flow analyzers incorporated into the editor can help analyze incomplete program fragments to locate and inform the user of possible errors or anomalies during programming.
Transfer of Tool Affordance and Manipulation Cues with 3D Vision Data

Future service robots working in human environments, such as kitchens, will face situations where they need to improvise. The usual tool for a given task might not be available and the robot will have to use some substitute tool. The robot needs to select an appropriate alternative tool from the candidates available, and also needs to know where to grasp it, how to orient it and what part to use as the end-effector. We present a system which takes as input a candidate tool's point cloud and weight, and outputs a score for how effective that tool is for a task, and how to use it. Our key novelty is in taking a task-driven approach, where the task exerts a top-down influence on how low level vision data is interpreted. This facilitates the type of 'everyday creativity' where an object such as a wine bottle could be used as a rolling pin, because the interpretation of the object is not fixed in advance, but rather results from the interaction between the bottom-up and top-down pressures at run-time. The top-down influence is implemented by transfer: prior knowledge of geometric features that make a tool good for a task is used to seek similar features in a candidate tool. The prior knowledge is learned by simulating Web models performing the tasks. We evaluate on a set of fifty household objects and five tasks. We compare our system with the closest one in the literature and show that we achieve significantly better results
Behavioral Health Outcomes Associated With Religious Faith and Media Exposure About Human Genetics

A number of scholars have speculated that religious people will be less likely than others to ascribe either fatalistic or deterministic powers to genes, opting instead to leave freedom as a choice for both God and humans. This research investigates the role of religious faith (RF) on behavioral health outcomes associated with information about genes and health, as well as its role as a gatekeeper to media information about genes and health. This research is based on the results of a survey of 858 members of the lay public, including northeastern and southeastern rural and urban participants. Findings are considered within frameworks of audience segmentation principles associated with RF.
Application of thin film transistors to label-free electrical biosensors

Biotechnology is in great need of low-cost intelligent biochips for massive parallel detection of biomolecular interactions, using portable instrumentation. One way this may be achieved is to exploit mature semiconductor technologies for the development of biosensor arrays. Thin film transistor technology in particular can play an important role in this rapidly expanding field. TFTs can be applied either as potentiometric sensors for the detection of different biomolecular interactions or as circuit elements for conditioning and read-out of signals of promising label free electrical detection techniques such as electrochemical impedance spectroscopy.
Consideration of antenna gain and phase patterns for calibration of polarimetric SAR data

A general polarimetric model for orbital and Earth synthetic aperture radar (SAR) systems that explicitly includes key radar architecture elements and is not dependent on the reciprocity assumption is developed. The model includes systems whose receiving configuration is independent of the transmitted polarization (one configuration), as well as systems with two distinct receiving configurations, depending on the commanded transmitted polarization (H or V). Parameters that are independent of target illumination angle and those with illumination angle dependence are considered separately, allowing calibration approaches which are valid for targets at different illumination angles. The calibration methods presented make use of the model linearity to provide tests for the radar model accuracy and for SAR data quality. X-band polarimetric SAR are used to validate the theory and illustrate the calibration approach. The extension of the model and calibration method to other radar systems is discussed. >