Miracle-dz/UniFAR-FTUs huggingface dataset:
Non‐technical skills training to enhance patient safety

Background: Patient safety is an increasingly recognised issue in health care. Systems‐based and organisational methods of quality improvement, as well as education focusing on key clinical areas, are common, but there are few reports of educational interventions that focus on non‐technical skills to address human factor sources of error. A flexible model for non‐technical skills training for health care professionals has been designed based on the best available evidence, and with sound theoretical foundations.
Surface modification of multiwalled carbon nanotubes via nitroxide‐mediated radical polymerization

The nitroxide-mediated radical polymerization of styrene was carried out on the surfaces of multiwalled carbon nanotubes (MWNTs) initiated by an MWNT- supported initiator multiwalled carbon nanotube-2@,2@,6@,6@-tetramethylpiperidiny- loxy (MWNT-Tempo). The content of polystyrene grafted from the surface was con- trolled by changes in the polymerization conditions, such as the reaction times or the ratios of monomers to initiators. The obtained polystyrene-grafted multiwalled carbon nanotubes (MWNT-PSs) were further used to initiate the polymerization of 4-vinyl- pyridine to get polystyrene-b-poly(4-vinylpyridine)-grafted multiwalled carbon nano- tubes (MWNT-PS-b-P4VPs). In contrast to unmodified MWNTs, MWNT-PSs had rel- atively good dispersibility in various organic solvents, such as tetrahydrofuran, CHCL3, and o-dichlorobenzene. The structures and properties of MWNT-PSs and MWNT-PS-b-P4VPs were characterized and studied with several methods, including thermogravimetric analysis, Fourier transform infrared, ultraviolet-visible, and transmission electron microscopy. V C 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym
Clinical combination of the MEK inhibitor GDC-0973 and the PI3K inhibitor GDC-0941: A first-in-human phase Ib study testing daily and intermittent dosing schedules in patients with advanced solid tumors.

3005^ Background: The RAS/RAF/MEK and PI3K/AKT signaling pathways are both deregulated in many tumor types. Targeting both pathways may be more efficacious than targeting either pathway alone. In preclinical models, concurrent administration of GDC-0973, a potent, selective, MEK1/2 inhibitor and GDC-0941, a potent class I PI3K inhibitor, shows improved efficacy compared to either alone when these agents are dosed either continuously or intermittently. METHODS A phase Ib dose-escalation study with 3+3 design was initiated in patients (pts) with advanced solid tumors to evaluate the safety and pharmacokinetics (PK) of oral combination dosing of GDC-0973 and GDC-0941. Pts received once daily (QD) GDC-0973 + GDC-0941 on a 21 day on/7 day off (21/7) schedule or intermittent GDC-0973 on Days 1, 4, 8, 11, 15, 18 of a 28 day cycle + GDC-0941 QD on a 21/7 schedule. Initial doses were 20 mg GDC-0973 + 80 mg GDC-0941 on 21/7 schedule; 100 mg GDC-0973 + 130 mg GDC-0941 on intermittent schedule. Serial plasma PK samples, FDG-PET and CT scans were obtained. RESULTS 30 pts have enrolled - 27 pts in 6 cohorts on 21/7 schedule; 3 pts on intermittent schedule. DLTs were grade 3 lipase (n=1) and grade 4 CPK elevation (n=1). Adverse events related to study drug combination were diarrhea (90%; all G1/2), fatigue (61%; 50% G1/2, 11% G3), nausea (61%; all G1/2), rash (50%; 45% G1/2, 5% G3), vomiting (33%; all G1/2), decreased appetite (17%; all G1/2), and dysgeusia (17%; all G1/2). Preliminary analysis indicates PK of GDC-0973 or GDC-0941 are not altered when dosed in combination. 6 of 15 pts had an FDG-PET partial metabolic response at one or more timepoints. Decreases in RECIST measurable target lesions were seen in 5 pts: 2 with melanoma (-75%; -27%), 1 prostate cancer (-21%), and 2 NSCLC (-18%; -13%). 3 pts had prolonged stable disease > 6 months. CONCLUSIONS Combination dosing of GDC-0973 and GDC-0941 is generally well tolerated, with toxicities similar to those observed in single agent GDC-0973 and GDC-0941 phase I trials. There are early signs of anti-tumor activity. Dose escalation on both schedules continues and updated data will be presented.
In Charisma We Trust: The Effects of CEO Charismatic Visions on Securities Analysts

Using a thematic text analysis of the initial letters to shareholders following a CEO succession event, we analyze whether CEO charismatic visions portrayed in this organizational discourse influence securities analysts' recommendations and forecasts. The results suggest that such projections of CEO charismatic visions are associated with the favorability of individual analyst recommendations and the uniformity of recommendations across analysts, but they also appear to be positively related to errors in individual analysts' forecasting of future firm performance.
Anti-windup applied to adaptive rejection of unknown narrow band disturbances

In this paper, a discrete-time anti-windup augmentation scheme is applied to a model of an active suspension system. The model faithfully reproduces the dynamics of an experimental setup available at the Laboratoire d'Automatique de Grenoble and provided by the Hutchinson Research Center. The underlying control system is an adaptive scheme achieving rejection of unknown narrow band disturbances by acting on a piston with the ultimate goal of reducing the resid- ual force on the top of the suspension. Since the piston is subject to magnitude saturation, the control system is prone to windup effects and experiences severe performance loss when large disturbances affect the suspension. The discrete- time anti-windup scheme, consisting in a copy of the plant that augments the controller dynamics, allows to partially recover the unconstrained performance and induces desirable responses for disturbances of different sizes: from very large to very small. Simulation results are reported to illustrate the effectiveness of the anti-windup solution.
Improved Distance Metric Learning for Nearest Neighbor Classification

L'apprentissage automatique concerne l'apprentissage de modeles predictifs a partir de donnee. Pour bien generaliser, beaucoup d'algorithme d'apprentissage automatique suppose que les predictions des points proches sont similaires. En consequence, comment mesurer la proximitee des points de donnees devient donc un element crucial d'algorithm d'apprentissage. L'apprentissage de metrique resout se defi en apprenant une metrique dependantes des donnees. Pendant les dix derniere annees, ceci a attire beaucoup d'attention et est devenu une des approches principales pour adresser des problemes d'apprentissage de distance/similarite. L'approche la plus etudiee est l'apprentissage de metrique individuel. Cela apprend une mesure de distance dans tout l'espace d'entree des donnees. Cette approche est souvent efficace computationelement. Cependant, il peut ne pas etre suffisament flexible pour bien apprendre la distance dans different voisinage de donnee. Tel que, la distance dans different voisinage peut etre bien approximee. L'apprentissage de metrique non lineaire suit une approche differente pour augmenter la complexitee du modele. Il envoie d'abord les points de donnee dans un nouvel espace de donnee par une application non lineaire d'attribut puis une metrique individuel est apprise dans le nouvel espace de donnee. Malgre le succes de differents algorithmes d'apprentissage de metrique, chaque algorithme possede ses propres limitations. Dans cette these, nous nous concentrons dans leur limitations et developpons de nouveau algorithme d'apprenttisage de metrique. Quatre different types d'algorithme d'apprentissage de metrique ont ete contribue, incluant un algorithme d'apprentissage de metrique individuel, un algorithme d'apprentissage de metrique local et deux algorithmes d'apprentissages non lineaire. Les algorithmes d'apprentissage de metrique developpe sont meilleur que les methodes de l'etat de l'art en terme de performance predictive et de scalabilitees algorithmique.
Granzyme B Proteolyzes Receptors Important to Proliferation and Survival, Tipping the Balance toward Apoptosis*

Granzyme B is critical to the ability of natural killer cells and cytotoxic T lymphocytes to induce efficient cell death of virally infected or tumor cell targets. Although granzyme B can cleave and activate caspases to induce apoptosis, granzyme B can also cause caspase-independent cell death. Thirteen prospective granzyme B substrates were identified from a cDNA expression-cleavage screen, including Hsp70, Notch1, fibroblast growth factor receptor-1 (FGFR1), poly-A-binding protein, cAbl, heterogeneous nuclear ribonucleoprotein H′, Br140, and intersectin-1. Validation revealed that Notch1 is a substrate of both granzyme B and caspases, whereas FGFR1 is a caspase-independent substrate of granzyme B. Proteolysis of FGFR1 in prostate cancer cells has functionally relevant consequences that indicate its cleavage may be advantageous for granzyme B to kill prostate cancer cells. Therefore, granzyme B not only activates pro-death functions within a target, but also has a previously unidentified role in inactivating pro-growth signals to cause cell death.
Teaching by Intervention: Working Backwards, Undoing Mistakes, or Correcting Mistakes?

When teaching, people often intentionally intervene on a learner while it is acting. For instance, a dog owner might move the dog so it eats out of the right bowl, or a coach might intervene while a tennis player is practicing to teach a skill. How do people teach by intervention? And how do these strategies interact with learning mechanisms? Here, we examine one global and two local strategies: working backwards from the end-goal of a task (backwards chaining), placing a learner in a previous state when an incorrect action was taken (undoing), or placing a learner in the state they would be in if they had taken the correct action (correcting). Depending on how the learner interprets an intervention, different teaching strategies result in better learning. We also examine how people teach by intervention in an interactive experiment and find a bias for using local strategies like undoing.
Theory of Lévy matrices.

We investigate the statistical properties of the spectrum of large symmetrical matrices with each element ${\mathit{H}}_{\mathit{i}\mathit{j}}$ chosen according to a broad distribution \ensuremath{\rho}(H) decaying for large H as ${\mathit{H}}^{\mathrm{\ensuremath{-}}1\mathrm{\ensuremath{-}}\mathrm{\ensuremath{\mu}}}$. For \ensuremath{\mu}g2, 〈${\mathit{H}}^{2}$〉 is finite and the well known Gaussian orthogonal ensemble (GOE) results are recovered. When \ensuremath{\mu}2, the semicircular law is replaced by a density which extends over the whole energy axis. Furthermore, while all states are extended in the case of GOE matrices, we show numerically and analytically that two mobility edges appear, separating extended from localized states, with an intermediate ``mixed'' phase in between. The unusual nature of these localized states is discussed.
Analyse d'un scénario de couplages sZb non standard : Etiquetage des saveurs auprès de l'expérience LHCb

Nous presentons dans cette these deux aspects de la physique de la beaute. Le premier est theorique et concerne l'etude d'effets de nouvelle physique dans certaines desintegrations de meson beaux. Nous avons estime les corrections qu'un scenario de couplages sZb non standard implique sur l'observable S presente dans l'asymetrie particule antiparticule dependante du temps. Une analyse globale de 6 modes exclusifs b→qqs ainsi que du mode inclusif b→lls nous a permis de predire une valeur de cette observable. Leur confrontation avec les mesures experimentales actuelles ne permet au final pas de mettre en defaut ce scenatio de nouvelle physique. Le deuxieme aspect est experimental et s'inscrit dans la collaboration LHCb. L'outils d'etiquetage des saveurs est un element important permettant la mesure d'observables CP. Nous avons tout d'abord etudier des methodes d'amelioration de l'algorithme d'etiquetage. Une classification des estimateurs de type leptons permet une amelioration en terme de puissance d'etiquetage. La construction de nouveaux estimateurs de type charges de jet permet egalement un gain et peuvent s'averer utile lors de verifications croisees. Enfin, nous avons propose deux nouveaux modes de controle permettant d'extraire la fraction de mauvais etiquetage cote oppose a partir des donnees. Pour chacun nous avons construit la selection, analyser le bruit de fond et estimer la precision sur cette extraction
Structure and Dynamics of Elastin Cross-linking Domains

Structure and Dynamics of Elastin Cross-linking Domains Aditi Ramesh Master of Science Graduate Department of Biochemistry University of Toronto 2015 The secondary structure of elastin cross-linking domains has been shown to be sequence and context dependent, but the role of these domains in the function of elastomeric proteins remains unclear. We use molecular dynamics simulations (MD), circular dichroism spectroscopy (CD), and nuclear magnetic resonance to probe the conformational equilibria of model elastin-like cross-linking peptides. We tested four recently developed force fields using MD to select the one that best reproduces the amount of alpha-helix seen in CD. Simulation studies of the aggregative properties of the cross-linking domains found that they occasionally interact, but not in any specific way. Additionally, multifaceted studies of biphasic systems show that these domains do not partition preferentially into or on the interface of a hydrophobic surface. Further experiments on constructs of crosslinking and hydrophobic domains will help elucidate how cross-linking modulates the self-assembly and mechanical properties of elastomeric proteins.
Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor

The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor/scatter factor (HGF/SF). It was previously shown that, like the oncogenic tpr-met, the mouse met proto-oncogene transforms NIH 3T3 cells. We have established NIH 3T3 cells stably expressing both human (Methu) and mouse (Metmu) met proto-oncogene products. The protein products are properly processed and appear on the cell surface. NIH 3T3 cells express endogenous mouse HGF/SF mRNA, suggesting an autocrine activation mechanism for transformation by Metmu. However, the tumor-forming activity of Methu in NIH 3T3 cells is very low compared with that of Metmu, but efficient tumorigenesis occurs when Methu and HGF/SFhu are coexpressed. These results are consistent with an autocrine transformation mechanism and suggest further that the endogenous murine factor inefficiently activates the tumorigenic potential of Methu. The tumorigenicity observed with reciprocal chimeric human and mouse receptors that exchange external ligand-binding domains supports this conclusion. We also show that HGF/SFhu expressed in NIH 3T3 cells produces tumors in nude mice.
Human Nature and Moral Understanding in Xunzi

Comment d'apres le philosophe ancien chinois, Xunzi (310-219 av. J.-C.), l'homme devient-il moral en le sens d'une reconnaissance des exigences de la moralite et en le sens de la possession des motivations appropriees. D'apres l'A. , la reponse a cette question est primordiale pour la comprehension de la philosophie ethique de Xunzi
High index contrast polymer optical waveguides

We report on a platform of polymer wave-guiding materials with properties amenable to subsequent doping with Semi-Conductor (SC) nanocrystals (NC). In this work we present the design of passive optical devices constructed with the polymer platform, its fabrication and characterization. A PFCB core and a Cytop© cladding (both being commercially available polymers) were chosen and combined as a core/cladding pair for the first time. These two polymers offer very small absorption at the optical communication wavelength of 1.55µm, and allow us to create high index contrast Δn of ∼10%, which allows single mode operation with mode diameter of 1.5 µm.
Analytical study of temperature distribution of one-layer EM-absorber using a lossy dielectric material

In this paper, first, FDTD, semi-implicit method for pressure linked equations (SIMPLE), Monte Carlo and radiative energy absorption distribution (READ) methods are combined to calculate electromagnetic field and all the heat transfer phenomena of heat transport, heat transfer by air convection and heat radiation (It is called FDTD-SIMPLE-MR method.). The temperature distribution of an one-layer EM-absorber using a lossy dielectric material under high power injection is calculated using FDTD-SIMPLE-MR method and a traditional method. And the both calculated temperature distributions of the absorber are compared. As a result, the more detailed temperature distribution of the absorber is obtained by FDTD-SIMPLE-MR method.
Selection of Novel Nickel‐binding Peptides from Flagella Displayed Secondary Peptide Library

Nickel (Ni) performs its biological or toxic functions in nickel–protein coordination form. Novel Ni‐binding peptides were isolated from a random dodecapeptide library displayed on the flagella of Escherichia coli against immobilized ions. On the basis of isolated sequences rich in histidine residues, two secondary libraries were constructed respectively. By consequent selection, more Ni‐chelating peptides were identified and the consensus motif RHXHR (where X was always H) was deduced. The result suggested that not only histidine, but also arginine, play an important role in Ni‐binding. Furthermore, two selected clones (1035 and 2022) were chosen for further identification. They exhibited similar relative binding affinity, which was about nine times that of the original library derived clones and statistically much more significant than the positive control with polyhistidine insert. Free nickel ions could almost completely inhibit the binding of the clones 1035 and 2022 to immobilized nickel, implicating that the peptides were able to chelate nickel ions. These studies reveal that bacterial surface displayed peptide libraries may have promising future potential for the development of metal bioadsorbents. Furthermore, novel Ni‐binding peptides may provide lead molecules for Ni‐chelation and applications thereof.
Spatial filter by using multilayered FSS for orthogonal polarization conversion

This paper proposes the spatial filter with FSS(Frequency Selective Surface) for orthogonal polarization conversion such as converting the vertical polarization to horizontal polarization. It is found that multilayered loop-slot type FSS having band-pass filter characteristics realize orthogonal polarization conversion. Furthermore, it is shown that the optimal number of layers of the FSS is three, and maximum value of relative bandwidth is 9.5%.
Effects of Hypericum perforatum extract on oxaliplatin-induced neurotoxicity: in vitro evaluations

Abstract Hypericum perforatum L. has been used for centuries as a natural remedy for the treatment of many disorders. Neuropathic pain is a common side effect of oxaliplatin-based chemotherapy and often the cause of therapy discontinuation. Thanks to its anti-inflammatory and analgesic effects, the use of H. perforatum may be a novel therapeutic strategy for neuropathy. The aim of this paper was to evaluate the effect of H. perforatum hydrophilic extract on an in vitro model of oxaliplatin-induced neurotoxicity. The antioxidant potential of extract was first evaluated in cell-free models by the thiobarbituric acid-reactive substances assay and nitro blue tetrazolium oxidation test; the ability of H. perforatum extract to reduce oxaliplatin-induced caspase-3 activity in rat astrocytes and its potential interference with the cytotoxic effects of oxaliplatin in a colorectal cancer in vitro model (HT-29 cells) were also evaluated. The extract showed a significant antioxidant effect and was able to reduce caspase-3 activity in rat astrocytes. Of note, the extract alone exerted a cytotoxic effect in HT-29 cells and did not reduce the cytotoxicity of oxaliplatin in HT-29 cells. These data suggest that H. perforatum could be used as a novel therapeutic strategy for counteracting chemotherapy-induced neuropathy.
Human leukocyte antigen class I expression. Marker of poor prognosis in uveal melanoma.

PURPOSE Because the expression of human leukocyte antigen (HLA) antigens is important for immunologic recognition of tumor cells, we determined expression of locus-specific HLA class I antigens in uveal melanoma and tested whether the level of HLA expression was related to prognosis or associated with known prognostic parameters. METHODS Expression of HLA-A and -B antigens was determined on 30 formalin-fixed and paraffin-embedded sections of uveal melanoma by immunohistochemistry with locus-specific monoclonal antibodies and scored semiquantitatively. RESULTS The level of expression of HLA-A and -B varied between uveal melanomas. Expression levels of HLA-A and -B were significantly correlated (P = 0.02). High HLA-B expression was significantly correlated with the presence of epithelioid cells (P = 0.04) in the tumor. Expression levels of HLA-A as well as of HLA-B, cell type, mitotic rate, Mib-1 score, and largest tumor diameter were significant predictive factors for survival. High expression of HLA-A and -B was associated with a decreased survival. Multiple Cox regression analysis with stepwise selection of covariates showed that the contribution of HLA-A expression to survival (P = 0.0003) exceeded that of tumor diameter (P = 0.02) and Mib-1 score (P = 0.04). CONCLUSIONS Lack of expression of HLA-A as well as of HLA-B antigens on uveal melanoma is correlated with a better patient survival. Our data suggest that shedding of uveal melanoma micrometastases with a low expression of HLA class I into the systemic circulation may facilitate their removal and prevent the development of metastases. These findings support a protective role for natural killer cells in the development of metastatic disease in uveal melanoma.