Miracle-dz/UniFAR-FTUs huggingface dataset:
Traveling forward in time to newer operating systems using ShadowReboot

This paper presents ShadowReboot, a virtual machine monitor (VMM)-based approach that shortens the downtime for software updates during an OS reboot. ShadowReboot reboots the guest OS in the background by spawning a VM dedicated to an OS reboot and enables the user to switch over to the rebooted state where the updated kernel and applications are ready for use. ShadowReboot provides an illusion to the users that the guest OS travels forward in time to the rebooted state where the updated kernel and applications are ready for use. ShadowReboot offers the following advantages. It can be applied to any patch to the kernels and even system configuration updates. Second, it does not need any special patch requiring intimate knowledge about the target kernels. Third, it does not require any target kernel modification. We implemented a prototype in VirtualBox 3.0. 8 OSE. Our preliminary experimental results show that ShadowReboot shortened the downtime of commodity OS reboots on Windows XP and five Linux distributions (Gentoo, Fedora, Cent, Ubuntu, and SUSE) by 43 to 96%.
Hypertension and its risk factors in tea garden workers of Assam.

BACKGROUND Hypertension is emerging as a major public health problem in India. The diversity and heterogeneity of distribution of the population makes it difficult to arrive at the precise prevalence. In Assam, reports from hospitals in tea gardens reveal a high prevalence of hypertension among workers in tea gardens. However, no systematic study has been carried out in this population. METHODS We selected, by systematic sampling, 1015 individuals (512 men and 503 women) 30 years or more in age, who were interviewed and clinically examined for hypertension. Blood pressure of all the study participants was measured using a standardized technique. Crude and adjusted odds ratios were estimated by unconditional simple and multiple logistic regression analyses. Mantel-Haenszel chi2 analysis was also used to test for the association of potential risk factors with hypertension after controlling for co-variables in a stratified analysis. Risk factors considered for hypertension included age, gender, marital status, occupation, alcohol consumption (locally prepared), extra salt intake, smoking history, khaini (a form of tobacco quid containing a mixture of tobacco and lime) intake, body mass index and waist-hip ratio. RESULTS The overall prevalence of hypertension was 60.8%. Increasing age, consumption of locally prepared alcohol, intake of extra salt in food and beverages and the habit of taking khaini were found to increase the risk of hypertension. Multivariate logistic regression models showed that the independent determinants of hypertension were age, gender, consumption of locally prepared alcohol and intake of extra salt. Gender-specific and age-stratified analyses showed the association of increased risk with intake of khaini in women only, while consumption of locally prepared alcohol was an important risk factor for hypertension in both men and women. CONCLUSION The disease burden of hypertension among workers in tea gardens is large, despite the community not being obese. Interventions directed at these workers as well as studies to determine the reasons for the high prevalence of hypertension are required.
Reassessment of Health-System Capacity for Experiential Education Requirements

Objective. To provide an update to the 2007 ASHP-AACP survey by examining the current capacity of hospitals/health systems’ ability to conduct experiential education for doctor of pharmacy students. Methods. Pharmacists identified as pharmacy directors were sent an invitation to participate in an online survey tool. The survey tool asked IPPE- and APPE-specific questions, the nature of support provided by colleges/schools of pharmacy, the types of experiences available for students, and the factors influencing the quality, value, and challenges of experiential education. Results. Four hundred sixty five of the 2,911 surveys sent were completed yielding a response rate of 16%. Respectively, 45.1% and 28.5% of respondents believe that the capacity for APPE and IPPE will increase in the next five years. Overall, respondents believe that students receive a high-quality experiential education (91.4%). Conclusion. The results of this survey provide insight to the capacity, benefits and challenges of experiential education from the perspective of hospitals/health systems.
Implementation of pharmacogenetics: The University of Maryland personalized anti‐platelet pharmacogenetics program

Despite a substantial evidence base, implementation of pharmacogenetics into routine patient care has been slow due to a number of non‐trivial practical barriers. We implemented a Personalized Anti‐platelet Pharmacogenetics Program (PAP3) for cardiac catheterization patients at the University of Maryland Medical Center and the Baltimore Veterans Administration Medical Center Patients' are offered CYP2C19 genetic testing, which is performed in our Clinical Laboratory Improvement Amendment (CLIA)‐certified Translational Genomics Laboratory. Results are returned within 5 hr along with clinical decision support that includes interpretation of results and prescribing recommendations for anti‐platelet therapy based on the Clinical Pharmacogenetics Implementation Consortium guidelines. Now with a working template for PAP3, implementation of other drug‐gene pairs is in process. Lessons learned as described in this article may prove useful to other medical centers as they implement pharmacogenetics into patient care, a critical step in the pathway to personalized and genomic medicine. © 2014 Wiley Periodicals, Inc.
110 W All Fiber Actively Q-Switched Thulium-Doped Fiber Laser

We report a 100-W-level, repetition rate and pulsewidth tunable, all-fiber, thulium-doped master oscillator power amplifier system. The master oscillator was actively Q-switched by a fiber-coupled acousto-optic modulator. The generated pulsewidth could be tuned from 1.16 μm to 46.3 ns by adjusting modulation repetition rate from 1 kHz to 2 MHz, and the pulse repetition rate (PRR) can also be tuned from 1 kHz to 2 MHz, correspondingly. The maximum output power could be boosted to > 110 W (slope efficiency of 55%) through three-stage thulium-doped fiber (TDF) amplifiers at PRR from 100 kHz to 2 MHz. The spectrum bandwidth was about 0.8 nm at the maximum output power without obvious indication of nonlinear effects. To the best of our knowledge, this is the first demonstration of > 110-W, all-fiber, actively Q-switched TDF laser, and it has realized the largest tuning ranges both with the pulsewidth and the PRR.
Wavelet-based Circular Hough Transform and Its Application in Embryo Development Analysis

Detecting object shapes from images remains a challenging problem in computer vision, especially in cases where some a priori knowledge of the shape of the objects of interest exists (such as circle-like shapes) and/or multiple object shapes overlap. This problem is important in the field of biology, particularly in the area of early-embryo development, where the dynamics is given by a set of cells (nearly-circular shapes) that overlap and eventually divide. We propose an approach to this problem that relies mainly on a variation of the circular Hough Transform where votes are weighted by wavelet kernels, and a fine-tuning stage based on dynamic programming. The wavelet-based circular Hough transform can be seen as a geometric-driven pulling mechanism in a set of convolved images, thus having important connections with well-stablished machine learning methods such as convolution networks.
Patients with Primary Sjögren's Syndrome Disturbance in the B Cell Subpopulations in Founder Cells in Healthy Individuals and B Cells Reveals Circulating Germinal Center Bm5 Classification of Peripheral Blood - Bm1

Analyses of B cells in the bone marrow and secondary lymphoid tissues have revealed a broad range of cell surface markers deﬁning B cell subpopulations, but only a few of these have been used to analyze B cell subpopulations in peripheral blood (PB). We report here the delineation of circulating PB B cell subpopulations by staining for CD19, CD38, and IgD in combination with CD10, CD44, CD77, CD95, CD23, IgM, and the B cell memory marker CD27. The utility of this approach is shown by the demonstration of disturbances of circulating B cell subpopulations in patients with autoimmune disease. Five mature B cell (Bm) subpopulations were identiﬁed in normal PB that were comparable with the tonsillar Bm1, Bm2, early Bm5, Bm5 subpopulations and, surprisingly, to the germinal center (GC) founder cell subpopulation (Bm2 (cid:1) and Bm3 (cid:1) –4 (cid:1) ), suggesting that some GC founder cells are circulating. No PB B cells resembled the Bm3 and Bm4 GC cells. Remarkably, some cells with the CD38 (cid:2) IgD (cid:3) phenotype, previously known as naive Bm1 cells, expressed CD27. The CD38 (cid:2) IgD (cid:3) subpopulation therefore includes both naive Bm1 cells and IgD (cid:3) memory B cells. This new classiﬁcation of B cell developmental stages reveals disturbances in the proportions of B cell subpopulations in primary Sjo¨gren’s syndrome (pSS) patients compared with healthy donors and rheumatoid arthritis patients.
ABCC 1 polymorphisms in anthracycline induced cardiotoxicity in childhood acute lymphoblastic leukemia

1 Department of Genetics, Celland Immunobiology, Semmelweis University, Budapest, Hungary 2 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary 3 Markusovszky Hospital of Vas county council, Szombathely, Hungary 4 Heim Pal Children Hospital, Budapest 5 Hungary; Inflammation biology and Immunogenomics Research Group, Hungarian Academy of Sciences Semmelweis University, Budapest, Hungary 6 Csertex Research Laboratory, Budapest, Hungary
Permissive Replication of Homologous Murine Rotavirus in the Mouse Intestine Is Primarily Regulated by VP4 and NSP1

ABSTRACT Homologous rotaviruses (RV) are, in general, more virulent and replicate more efficiently than heterologous RV in the intestine of the homologous host. The genetic basis for RV host range restriction is not fully understood and is likely to be multigenic. In previous studies, RV genes encoding VP3, VP4, VP7, nonstructural protein 1 (NSP1), and NSP4 have all been implicated in strain- and host species-specific infection. These studies used different RV strains, variable measurements of host range, and different animal hosts, and no clear consensus on the host range restriction determinants emerged. We used a murine model to demonstrate that enteric replication of murine RV EW is 1,000- to 10,000-fold greater than that of a simian rotavirus (RRV) in suckling mice. Intestinal replication of a series of EW × RRV reassortants was used to identify several RV genes that influenced RV replication in the intestine. The role of VP4 (encoded by gene 4) in enteric infection was strain specific. RRV VP4 reduced murine RV infectivity only slightly; however, a reassortant expressing VP4 from a bovine RV strain (UK) severely restricted intestinal replication in the suckling mice. The homologous murine EW NSP1 (encoded by gene 5) was necessary but not sufficient for promoting efficient enteric growth. Efficient enteric replication required a constellation of murine genes encoding VP3, NSP2, and NSP3 along with NSP1.
Application of the GA/KNN method to SELDI proteomics data

SUMMARY Proteomics technology has shown promise in identifying biomarkers for disease, toxicant exposure and stress. We show by example that the genetic algorithm/k-nearest neighbors method, developed for mining high-dimensional microarray gene expression data, is also capable of mining surface enhanced laser desorption/ionization-time-of-flight proteomics data. AVAILABILITY The source code of the program and documentation on how to use it are freely available to non-commercial users at http://dir.niehs. nih.gov/dirbb/lifiles/softlic.htm
Teaching "people networking" skills for CIS students

Recent research on organizational social networks has continued to emphasize the importance of networks for individual as well as organizational performance in the U.S. Given the importance of networks and networking, we argue that IT students must learn networking skills in addition to technical skills in order to better understand the role of technology in organizations and to increase their chances of success in their careers. The goal of this paper is to describe a teaching module that we developed for CIS undergraduate students to improve their networking skills.
Remarks by Governor

Achieving and maintaining price stability is the bedrock principle of a sound monetary policy. Price stability promotes economic growth and welfare by increasing the efficiency of the market mechanism, facilitating long-term planning, and minimizing distortions created by the interaction of inflation and the tax code, accounting rules, financial contracts, and the like. Price stability also increases economic welfare by promoting stability in output and employment. In particular, the marked decline in the variability of both inflation and output in recent decades, not only in the United States but also in most of the rest of the world, is by no means an accident. A significant portion of this improved performance has resulted from a reorientation of central bank policies toward a greater emphasis on keeping inflation low and stable. These policies have helped to anchor the public's inflation expectations at a low level, which has not only helped to contain inflation but has also given central banks greater latitude to stabilize the real economy with less concern than in the past about potential inflationary consequences.
A particle swarm optimisation for fuzzy dynamic facility layout problem

Dynamic facility layout problem (DFLP) deals with arranging and rearranging the layout plan of a manufacturing system or a service provider throughout several periods. In each period, the material handling costs are different from the previous periods due to the change in the market demand and product mix. Since the problem is NP-hard, numerous approaches have been proposed in the literature in order to find near-optimum solutions of the DFLP. In this paper, we model the natural uncertainty in material handling costs with fuzzy theory. A fuzzy particle swarm optimisation (FPSO) algorithm is proposed to solve the problem. We implement a number of ranking criteria from the literature in order to test the performance of the developed algorithm. Computational results confirm the efficiency and effectiveness of the proposed mechanisms.
An Insulin-Like Growth Factor 1 Receptor Inhibitor Induces CYP3A4 Expression through a Pregnane X Receptor-Independent, Noncanonical Constitutive Androstane Receptor-Related Mechanism

Inhibition of insulin-like growth factor-1 receptor (IGF-1R) signaling represents an attractive therapeutic strategy for cancer treatment. A first-generation IGF-1R inhibitor (R)-4-(3-(3-chlorophenyl)-3-hydroxypropyl)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-536924), however, was associated with potent CYP3A4 induction mediated by pregnane X receptor (PXR; NR1I2) transactivation. Structural activity-based modification led to the synthesis of 4-(1-(2-(4-((2-(4-chloro-1H-pyrazol-1-yl)ethyl)amino)-2-oxo-1,2-dihydropyridin-3-yl)-4-methyl-1H-benzo[d]imidazol-6-yl)piperidin-4-yl) piperazine-1-carboxylate (BMS-665351) with no PXR activity while maintaining its ability to inhibit IGF-1R. However, BMS-665351 significantly induces CYP3A4 expression in human primary hepatocytes (HPHs). Here, we report a novel nonclassical constitutive androstane receptor (CAR; NR1I3)-related pathway of BMS-665351-mediated CYP3A4 induction. BMS-665351 treatment resulted in the significant induction of CYP3A4 in HPHs and HepG2 cells, but failed to activate either PXR or CAR in cell-based reporter assays. Moreover, BMS-665351 at concentrations that induce CYP3A4 expression was unable to translocate human CAR from the cytoplasm to the nucleus of HPHs, which represents the initial step of CAR activation. Nevertheless, quantitative polymerase chain reaction analysis demonstrated that BMS-665351 significantly enhanced the expression of CYP3A4 in CAR- but not PXR-transfected HepG2 and Huh7 cells. It is noteworthy that BMS-665351 selectively induced the expression of CAR but not PXR in all tested hepatic cell systems. Synergistic induction of CYP3A4 was observed in HPHs cotreated with BMS-665351 and prototypical activators of CAR but not PXR. In summary, our results indicate that BMS-665351-mediated induction of CYP3A4 is CAR-dependent, but BMS-665351 itself is not a typical activator of either CAR or PXR, rather it functions as a selective inducer of CAR expression and increases CYP3A4 through a noncanonical CAR-related mechanism.
Orchestration of Thiamin Biosynthesis and Central Metabolism by Combined Action of the Thiamin Pyrophosphate Riboswitch and the Circadian Clock in Arabidopsis[C][W]

This study reports on the physiological role of the TPP riboswitch noncoding RNA element in balancing thiamin levels, plant metabolism, and overall organismal fitness. The model suggests that in Arabidopsis, the THIC promoter and the riboswitch simultaneously tightly regulate thiamin biosynthesis in a circadian manner and consequently sense and control vital points of core cellular metabolism. Riboswitches are natural RNA elements that posttranscriptionally regulate gene expression by binding small molecules and thereby autonomously control intracellular levels of these metabolites. Although riboswitch-based mechanisms have been examined extensively, the integration of their activity with global physiology and metabolism has been largely overlooked. Here, we explored the regulation of thiamin biosynthesis and the consequences of thiamin pyrophosphate riboswitch deficiency on metabolism in Arabidopsis thaliana. Our results show that thiamin biosynthesis is largely regulated by the circadian clock via the activity of the THIAMIN C SYNTHASE (THIC) promoter, while the riboswitch located at the 3′ untranslated region of this gene controls overall thiamin biosynthesis. Surprisingly, the results also indicate that the rate of thiamin biosynthesis directs the activity of thiamin-requiring enzymes and consecutively determines the rate of carbohydrate oxidation via the tricarboxylic acid cycle and pentose-phosphate pathway. Our model suggests that in Arabidopsis, the THIC promoter and the thiamin-pyrophosphate riboswitch act simultaneously to tightly regulate thiamin biosynthesis in a circadian manner and consequently sense and control vital points of core cellular metabolism.
Application-Specific Digital Forensics Investigative Model in Internet of Things (IoT)

Besides its enormous benefits to the industry and community the Internet of Things (IoT) has introduced unique security challenges to its enablers and adopters. As the trend in cybersecurity threats continue to grow, it is likely to influence IoT deployments. Therefore it is eminent that besides strengthening the security of IoT systems we develop effective digital forensics techniques that when breaches occur we can track the sources of attacks and bring perpetrators to the due process with reliable digital evidence. The biggest challenge in this regard is the heterogeneous nature of devices in IoT systems and lack of unified standards. In this paper we investigate digital forensics from IoT perspectives. We argue that besides traditional digital forensics practices it is important to have application-specific forensics in place to ensure collection of evidence in context of specific IoT applications. We consider top three IoT applications and introduce a model which deals with not just traditional forensics but is applicable in digital as well as application-specific forensics process. We believe that the proposed model will enable collection, examination, analysis and reporting of forensically sound evidence in an IoT application-specific digital forensics investigation.
MOLE: A data management application based on a protein production data model

MOLE (mining, organizing, and logging experiments) has been developed to meet the growing data management and target tracking needs of molecular biologists and protein crystallographers. The prototype reported here will become a Laboratory Information Management System (LIMS) to help protein scientists manage the large amounts of laboratory data being generated due to the acceleration in proteome research and will furthermore facilitate collaborations between groups based at different sites. To achieve this, MOLE is based on the data model for protein production devised at the European Bioinformatics Institute (Pajon A, et al., Proteins in press). Proteins 2005. © 2004 Wiley‐Liss, Inc.
Effects of a novel anti-exospore monoclonal antibody on microsporidial Nosema bombycis germination and reproduction in vitro

SUMMARY A monoclonal antibody (mAb) 3C2, against an exospore protein of the microsporidium Nosema bombycis (N. bombycis) was prepared, and its effects on microsporidial germination and reproduction in vitro were studied. MAb 3C2 was effective in inhibiting the germination and subsequent infection of Bombyx mori cells compared to the control mAb. The antigen was isolated by 2-dimensional gel electrophoresis. Immunoblotting revealed it to be an 84 kDa protein corresponding to pI (7·2) on the 2-D gel. The present results suggest that the antibodies can be used for diagnostic purposes and for developing new therapeutic strategies in controlling microsporidian diseases.
Better Demand Signal, Better Decisions? Evaluation of Big Data in a Licensed Remanufacturing Supply Chain with Environmental Risk Considerations

Big data ability helps obtain more accurate demand signal. However, is better demand signal always beneficial for the supply chain parties? To answer this question, we investigate a remanufacturing supply chain (RSC), where demand uncertainty is significant, and the value to reduce environmental risk is large. Specifically, we focus on a licensed RSC comprising an original equipment manufacturer (OEM) and a third‐party remanufacturer (3PR). The latter pays a unit license fee to the former, and can be risk averse to the demand of remanufactured products. We show that the OEM and the risk‐neutral 3PR always have incentives to improve their big data abilities to increase their profits. However, when the 3PR is risk averse, big data might hurt its profit: the value of big data is positive if its demand signal accuracy is sufficiently low. Interestingly, we find that while information sharing hurts the 3PR, it benefits the OEM as well as the supply chain. Thus, if costly information sharing is allowed, a win–win situation can be achieved. We also find that information sharing generates more valuation when the 3PR is risk averse than that when the 3PR is risk neutral. More importantly, we find that the 3PR's risk attitude and demand signal accuracy can significantly mitigate the negative environmental impact (measured by the amount of the waste): (1) the more risk neutral the 3PR is, the better the environment is; (2) the more accurate demand signal is, the better the environment is.
Quantum Chaos on Random Cayley Graphs of

ABSTRACT We investigate the statistical behavior of the eigenvalues and diameter of random Cayley graphs of as the prime number p goes to infinity. We prove a density theorem for the number of exceptional eigenvalues of random Cayley graphs, i.e., the eigenvalues with absolute value bigger than the optimal spectral bound. Our numerical results suggest that random Cayley graphs of and the explicit LPS Ramanujan projective graphs of have optimal spectral gap and diameter as the prime number p goes to infinity.