Miracle-dz/UniFAR-FTUs huggingface dataset:
HIV / AIDS and Economic Growth : An Econometric Analysis with Particular Consideration of the Role of Education Capital Accumulation

This paper investigates, using a panel data approach, the effects of the HIV/AIDS epidemic on economic growth using a neoclassical growth model that incorporates human capital in the form of both health capital and a Mincerian specification of education capital that encompasses both quantitative and qualitative components. Two important innovations of my analysis are that: (i) it represents the first cross-country econometric assessment that pays particular attention to human capital accumulation through education, and (ii) it implements the dynamic panel system-GMM estimator that is know to be superior to alternative estimators that underlie previous econometric assessments of the epidemic. Based on a sample spanning 45 years and 142 countries, results indicate that the epidemic’s effects on growth have been large and that a material component of this effect is due to its detrimental impact on the accumulation of education capital. For a full world sample and a sub-sample of developing world countries, the impact of a 1% increase in adult HIV prevalence is estimated to be a reduction in income per capita of around 0.14% and 0.12% on average respectively, which is substantially larger than that found in previous econometric assessments of the epidemic. JEL Classification: O11; O15; O47; I12; I20.
Pisa syndrome in Parkinson's disease: An integrated approach from pathophysiology to management

Pisa syndrome was first described in 1972 in patients treated with neuroleptics. Since 2003, when it was first reported in patients with Parkinson's disease (PD), Pisa syndrome has progressively drawn the attention of clinicians and researchers. Although emerging evidence has partially clarified its prevalence and pathophysiology, the current debate revolves around diagnostic criteria and assessment and the effectiveness of pharmacological, surgical, and rehabilitative approaches. Contrary to initial thought, Pisa syndrome is common among PD patients, with an estimated prevalence of 8.8% according to a large survey. Furthermore, it is associated with the following specific patient features: more severe motor phenotype, ongoing combined pharmacological treatment with levodopa and dopamine agonists, gait disorders, and such comorbidities as osteoporosis and arthrosis. The present literature on treatment outcomes is scant, and the uneven effectiveness of specific treatments has produced conflicting results. This might be because of the limited knowledge of Pisa syndrome pathophysiology and its variable clinical presentation, which further complicates designing randomized clinical trials on this condition. However, because some forms of Pisa syndrome are potentially reversible, there is growing consensus on the importance of its early recognition and the importance of pharmacological adjustment and rehabilitation. © 2016 International Parkinson and Movement Disorder Society.
Globalization, knowledge, skills and development : possible new directions for international and comparative education research in Southern Africa

Issues of globalization, knowledge, skills and development have become central to educational debates internationally during the past 15 years. Both policymakers and researchers have stressed the ways in which certain skills and knowledges have become central to economic growth, competitiveness, employability and social inclusion as the forces of globalization change the policy terrain. However, these debates have been relatively neglected in research terms in Southern Africa. This paper argues a case for broadening the focus of Southern African educational research by suggesting three main directions in which international and comparative educationalists in Southern Africa might usefully look in further developing their field: looking beyond schools, beyond education; and beyond national boundaries. However, identifying new research areas and motivating for them is not enough. Mindful that there are complex reasons for the limited development of Southern African research in these areas, it is necessary also to look inwardly at the political economy of knowledge production in international and comparative education in Southern Africa as a means of developing realistic strategies for moving forwards and outwards.
The reciprocal coordination and mechanics of molecular motors in living cells

Molecular motors in living cells are involved in whole-cell locomotion, contractility, developmental shape changes, and organelle movement and positioning. Whether motors of different directionality are functionally coordinated in cells or operate in a semirandom “tug of war” is unclear. We show here that anterograde and retrograde microtubule-based motors in the flagella of Chlamydomonas are regulated such that only motors of a common directionality are engaged at any single time. A laser trap was used to position microspheres on the plasma membrane of immobilized paralyzed Chlamydomonas flagella. The anterograde and retrograde movements of the microsphere were measured with nanometer resolution as microtubule-based motors engaged the transmembrane protein FMG-1. An average of 10 motors acted to move the microsphere in either direction. Reversal of direction during a transport event was uncommon, and quiescent periods separated every transport event, suggesting the coordinated and exclusive action of only a single motor type. After a jump to 32 °C, temperature-sensitive mutants of kinesin-2 (fla10) showed exclusively retrograde transport events, driven by 7 motors on average. These data suggest that molecular motors in living cells can be reciprocally coordinated to engage simultaneously in large numbers and for exclusive transport in a single direction, even when a mixed population of motors is present. This offers a unique model for studying the mechanics, regulation, and directional coordination of molecular motors in a living intracellular environment.
The histone demethylase KDM1A is essential for the maintenance and differentiation of spermatogonial stem cells and progenitors

Little is known of the fundamental processes governed by epigenetic mechanisms in the supplier cells of spermatogenesis, the spermatogonial stem cells (SSCs). The histone H3 lysine demethylase KDM1A is expressed in spermatogonia. We hypothesized that KDM1A serves in transcriptional regulation of SSCs and fertility. Using a conditional deletion of Kdm1a [conditional knockout (cKO)] in mouse spermatogonia, we determined that Kdm1a is essential for spermatogenesis as adult cKO males completely lack germ cells. Analysis of postnatal testis development revealed that undifferentiated and differentiating spermatogonial populations form in Kdm1a‐cKO animals, yet the majority fail to enter meiosis. Loss of germ cells in the cKO was rapid with none remaining by postnatal day (PND) 21. To gain insight into the mechanistic implications of Kdm1a ablation, we isolated PND 6 spermatogonia enriched for SSCs and analyzed their transcriptome by RNA sequencing. Loss of Kdm1a was associated with altered transcription of 1206 genes. Importantly, differentially expressed genes between control and Kdm1a‐cKO animals included those that are essential for SSC and progenitor maintenance and spermatogonial differentiation. The complete loss of fertility and failure to establish spermatogenesis indicate that Kdm1a is a master controller of gene transcription in spermatogonia and is required for SSC and progenitor maintenance and differentiation. —Lambrot, R. , Lafleur, C. , Kimmins, S. The histone demethylase KDM1A is essential for the maintenance and differentiation of spermatogonial stem cells and progenitors. FASEB J. 29, 4402‐4416 (2015). www.fasebj. org
Vestibular-evoked myogenic potential in patients with unilateral vestibular neuritis: abnormal VEMP and its recovery

The incidence of inferior vestibular nerve disorders in patients suffering from unilateral vestibular neuritis and the recovery of these disorders were evaluated by monitoring the vestibular-evoked myogenic potential (VEMP). Eight patients ranged from 21 to 73 years that suffered from unilateral vestibular neuritis underwent VEMP and caloric testing. Abnormal VEMP was observed in two of the eight patients with unilateral vestibular neuritis. Two patients were diagnosed as having an inferior vestibular nerve disorder. One of these patients showed recovery of the inferior vestibular nerve function as assessed by the VEMP. Disorders of the inferior vestibular nerve function and their recovery was confirmed by our current results. The time course of recoveries of the superior and inferior vestibular nerve systems were similar in the two patients.
Supplementation of ammoniated wheat straw: performance and forage utilization characteristics in beef cattle receiving energy and protein supplements.

Two experiments were conducted to evaluate performance and forage utilization characteristics of beef cattle fed ammoniated wheat straw (AWS) unsupplemented except for minerals or supplemented with energy and protein. In Exp. 1, 194 crossbred beef cows (BW = 472 kg) in late gestation were allotted by weight, breed type, and age during two consecutive winters to 12 drylot pens (three pens/treatment) for a 60-d feeding trial. The AWS (3% NH3 wt/wt) was tubground through a 7.6-cm screen, and cows were allowed ad libitum access to the AWS. In Exp. 2, 16 ruminally fistulated Angus x Hereford steers (BW = 300 kg) were blocked by weight and randomized to treatments in a 35-d intake-digestion trial. Daily supplementation treatments in both experiments were Control, no supplemental energy or protein; LSG, 1.36 kg of sorghum grain (SG); HSG, 2.72 kg of SG; and SG + SBM, 1.02 kg of SG + . 34 kg of soybean meal (SBM). All animals received . 23 kg of mineral mixture formulated to meet a pregnant cow's mineral requirements. Supplements LSG and SG + SBM were fed to provide the same daily ME, and HSG and SG + SBM were fed to provide the same daily CP. Cows were managed as one group during and after calving. In Exp. 1, all supplements increased gain (P less than .01) vs Control, and cows fed SG + SBM had higher (P = .05) gains than those fed LSG. The SG + SBM supplement increased (P less than .01) change in cow body condition score compared with LSG. (ABSTRACT TRUNCATED AT 250 WORDS)
How to Learn a Model Checker

We show how machine-learning techniques, particularly neural networks, offer a very effective and highly efficient solution to the approximate model-checking problem for continuous and hybrid systems, a solution where the general-purpose model checker is replaced by a model-specific classifier trained by sampling model trajectories. To the best of our knowledge, we are the first to establish this link from machine learning to model checking. Our method comprises a pipeline of analysis techniques for estimating and obtaining statistical guarantees on the classifier's prediction performance, as well as tuning techniques to improve such performance. Our experimental evaluation considers the time-bounded reachability problem for three well-established benchmarks in the hybrid systems community. On these examples, we achieve an accuracy of 99.82% to 100% and a false-negative rate (incorrectly predicting that unsafe states are not reachable from a given state) of 0.0007 to 0. We believe that this level of accuracy is acceptable in many practical applications and we show how the approximate model checker can be made more conservative by tuning the classifier through further training and selection of the classification threshold.
Genetic stability of gene targeted immunoglobulin loci. I. Heavy chain isotype exchange induced by a universal gene replacement vector

Gene targeting at the immunoglobulin loci of B cells is an efficient tool for studying immunoglobulin expression or generating chimeric antibodies. We have shown that vector integration induced by human immunoglobulin G1 (IgG1) insertion vectors results in subsequent vector excision mediated by the duplicated target sequence, whereas replacement events which could be induced by the same constructs remain stable. We could demonstrate that the distribution of the vector homology strongly influences the genetic stability obtained. To this end we developed a novel type of a heavy chain replacement vector making use of the heavy chain class switch recombination sequence. Despite the presence of a two‐sided homology this construct is universally applicable irrespective of the constant gene region utilized by the B cell. In comparison to an integration vector the frequency of stable incorporation was strongly increased, but we still observed vector excision, although at a markedly reduced rate. The latter events even occurred with circular constructs. Linearization of the construct at various sites and the comparison with an integration vector that carries the identical homology sequence, but differs in the distribution of homology, revealed the following features of homologous recombination of immunoglobulin genes: (i) the integration frequency is only determined by the length of the homology flank where the cross‐over takes place; (ii) a 5′ flank that does not meet the minimum requirement of homology length cannot be complemented by a sufficient 3′ flank; (iii) free vector ends play a role for integration as well as for replacement targeting; (iv) truncating recombination events are suppressed in the presence of two flanks. Furthermore, we show that the switch region that was used as 3′ flank is non‐functional in an inverted orientation.
Excessive maternal caffeine exposure during pregnancy is cataractogenic for neonatal crystalline lenses in rats: a biomicroscopic and histopathologic study.

PURPOSE To investigate histologically the influence of maternal caffeine exposure during pregnancy in vivo on crystalline lenses in neonatal rats. METHODS Experimentally naive, female Wistar-albino rats (200-220 g) were mated with adult male rats over 2 days for copulation. After confirming pregnancy with a vaginal smear method, 50 gravid rats (dams) were randomly divided into five groups (n = 10 in each), consisting of one control and four experimental groups. Groups 1, 2 and 3 experimental dams were treated with intraperitoneal (i.p.) caffeine at doses of 25, 50 and 100 mg/kg/day, respectively, during pregnancy from gestational day 9 through to day 21. Group 4 dams were treated with caffeine in distilled water in a gavage at a dose of 50 mg/kg/day. Group 5 control dams were given i.p. saline solution daily for the same period. After normal delivery, the eyes were examined by slit-lamp biomicroscopy. The neonates were then killed by decapitation at postnatal days 1 or 30 and the eyes removed for histopathologic investigation of the lenses. RESULTS Group 1 and control eyes had normal anterior lens capsules with a single layer of anterior cuboidal epithelial cells, regularly oriented cortical and nuclear lens fibres, and a clear posterior lens capsule with no lining epithelial cells behind the equator. In the remaining groups, histopathologic findings suggesting cataractogenesis included eosinophilic degeneration, lens fibre cell swelling and liquefaction, central lens fibres with retained nuclei, and prominent epithelial cells lining the posterior lens capsule behind the equator. Moreover, some lenses in group 3 had immature cataract on slit-lamp biomicroscopic examination at postnatal day 30. CONCLUSION Excessive maternal caffeine exposure during pregnancy had cataractogenic effects on developing crystalline lenses in newborn rat eyes, both macroscopically and histopathologically. If an appropriate dose of caffeine can be identified, caffeine-induced cataract formation may be used as a new experimental cataract model in animal studies.
Telomerase activity in central nervous system malignant lymphoma

Primary central nervous system malignant lymphoma (PCNSL) has been regarded as a rare neoplasm. Recently, however, its incidence has been rapidly increasing. Despite active clinical trials, its clinical and biologic features remain unknown and there has been no effective treatment or prognostic factor. The current study attempted to elucidate telomerase activity and expression of the telomere‐related RNA of PCNSL as novel prognostic factors.
The Impact of Playworks on Students' Physical Activity by Race/Ethnicity: Findings from a Randomized Controlled Trial.

BACKGROUND The Playworks program places coaches in low-income urban schools to engage students in physical activity during recess. The purpose of this study was to estimate the impact of Playworks on students' physical activity separately for Hispanic, non-Hispanic black, and non-Hispanic white students. METHODS Twenty-seven schools from 6 cities were randomly assigned to treatment and control groups. Accelerometers were used to measure the intensity of students' physical activity, the number of steps taken, and the percentage of time in moderate-to-vigorous physical activity (MVPA) during recess. The impact of Playworks was estimated by comparing average physical activity outcomes in treatment and control groups. RESULTS Compared with non-Hispanic black students in control schools, non-Hispanic black students in Playworks schools recorded 338 more intensity counts per minute, 4.9 more steps per minute, and 6.3 percentage points more time in MVPA during recess. Playworks also had an impact on the number of steps per minute during recess for Hispanic students but no significant impact on the physical activity of non-Hispanic white students. CONCLUSIONS The impact of Playworks was larger among minority students than among non-Hispanic white students. One possible explanation is that minority students in non-Playworks schools typically engaged in less physical activity, suggesting that there is more room for improvement.
Breakthrough Technologies 3 D Sorghum Reconstructions from Depth Images Identify QTL Regulating Shoot Architecture 1 [ OPEN ]

Dissecting the genetic basis of complex traits is aided by frequent and nondestructive measurements. Advances in range imaging technologies enable the rapid acquisition of three-dimensional (3D) data from an imaged scene. A depth camera was used to acquire images of sorghum (Sorghum bicolor), an important grain, forage, and bioenergy crop, at multiple developmental time points from a greenhouse-grown recombinant inbred line population. A semiautomated software pipeline was developed and used to generate segmented, 3D plant reconstructions from the images. Automated measurements made from 3D plant reconstructions identified quantitative trait loci for standard measures of shoot architecture, such as shoot height, leaf angle, and leaf length, and for novel composite traits, such as shoot compactness. The phenotypic variability associated with some of the quantitative trait loci displayed differences in temporal prevalence; for example, alleles closely linked with the sorghum Dwarf3 gene, an auxin transporter and pleiotropic regulator of both leaf inclination angle and shoot height, influence leaf angle prior to an effect on shoot height. Furthermore, variability in composite phenotypes that measure overall shoot architecture, such as shoot compactness, is regulated by loci underlying component phenotypes like leaf angle. As such, depth imaging is an economical and rapid method to acquire shoot architecture phenotypes in agriculturally important plants like sorghum to study the genetic basis of complex traits.
Care patterns for affective psychosis across diverse ethnicities: exploring potential contributors to complications and emergency room utilization.

OBJECTIVE To explore associations between access to care and environmental stressors with emergency room admissions; to evaluate patterns of complications across diverse ethnic groups related to affective psychosis. METHODS Data from the National Inpatient Sample were used to evaluate complications and frequency of hospitalization through the emergency room as a proportion of all hospital admissions for affective psychosis across diverse ethnic groups. Unemployment data, variations of trends of proportions of emergency room admissions after the September 11th tragedy, and ratios of primary care physicians/psychiatrists to the general population were evaluated. RESULTS Admissions through the emergency room as a percentage of all admissions for affective psychosis decreased from 1995 through 1999 but increased in 2001, showing a potential association with increasing unemployment rates and the September 11th tragedy. Over the same period, relatively higher frequencies of emergency room admissions as a proportion of all hospital admissions among African Americans decreased. No significant differences for complications or emergency room utilization were observed between African Americans and Whites by 2001. During the entire period, frequencies of complications in the Hispanic and Asian populations remained lower than frequencies in both African American and White populations. No associations were found between physician-to-population ratios and utilization of the emergency room. CONCLUSION Patterns of emergency room utilization and complications in African American and White populations appear to show some association with environmental stressors. Further study is warranted to evaluate protective factors associated with lower risk of complications in both Hispanic and Asian populations.
Natural Selection Types and Firm Diversity: An Evolutionary Extension of Endogenous Growth Theory

In this paper, we propose an evolutionary extension of Schumpeterian endogenous growth model with multi-sector by introducing the three types of natural selection: stabilizing selection, directional selection, and disruptive selection. Based on them, the survival of firms is determined in each period. As a metrics of survival rates, we incorporate "firm fitness'' in the economy into a well-known endogenous economic growth model. Moreover, in this model, firms can enter, exit, and move among sectors. In addition, the model permits us to simulate the economy's aggregate productivity as well as firm diversity in the three types of natural selection. For stabilizing and directional selection when firms enter and exit, firm diversity decreases, but aggregate productivity greatly improves. On the other hand, in the case of disruptive selection, aggregate productivity increases only by a small amount, but diversity increases. Thus, stabilizing and directional selection are more effective for improving short-run aggregate productivity. But firms will become weaker in the presence of future environmental changes such as innovations of general-purpose technology, climate changes, and social regime changes, because diversity decreases. With drastic environmental changes, the fall-off in aggregate productivity will be great. In contrast, disruptive selection is not effective for improving short-run aggregate productivity. The economy, however, will become relatively robust in the occurrence of future environmental changes, since firm diversity increases.