Miracle-dz/UniFAR-FTUs huggingface dataset:
Deregulated Expression of Superoxide Dismutase-2 Correlates with Different Stages of Cervical Neoplasia

Objective: Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme may be involved in carcinogenesis, particularly in lung, gastric, colorectal and breast cancer. Methods: In the present study, we have evaluated SOD2 protein levels by immunohistochemistry (IHC) in 331 cervical histological samples including 31 low-grade cervical intraepithelial neoplasia (LSIL), 51 high-grade cervical intraepithelial neoplasia (HSIL), 197 squamous cervical carcinomas (SCC) and 52 cervical adenocarcinomas (ADENO). Results: We observed that SOD2 staining increases with cervical disease severity. Intense SOD2 staining was found in 13% of LSIL, 25.5% of HSIL and 40% of SCC. Moreover, 65.4% of ADENO exhibited intense SOD2 staining. Conclusions: Differences in the expression of SOD2 could potentially be used as a biomarker for the characterization of different stages of cervical disease.
Notch Signaling Regulates Smooth Muscle Differentiation of Epicardium-Derived Cells

Rationale: The embryonic epicardium plays a crucial role in the formation of the coronary vasculature and in myocardial development, yet the exact contribution of epicardium-derived cells (EPDCs) to the vascular and connective tissue of the heart, and the factors that regulate epicardial differentiation, are insufficiently understood. Objective: To define the role of Notch signaling in murine epicardial development. Methods and Results: Using in situ hybridization and RT-PCR analyses, we detected expression of a number of Notch receptor and ligand genes in early epicardial development, as well as during formation of coronary arteries. Mice with epicardial deletion of Rbpj, the unique intracellular mediator of Notch signaling, survived to adulthood and exhibited enlarged coronary venous and arterial beds. Using a Tbx18-based genetic lineage tracing system, we show that EPDCs give rise to fibroblasts and coronary smooth muscle cells (SMCs) but not to endothelial cells in the wild type, whereas in Rbpj-deficient embryos EPDCs form and surround the developing arteries but fail to differentiate into SMCs. Conditional activation of Notch signaling results in premature SMC differentiation of epicardial cells and prevents coronary angiogenesis. We further show that Notch signaling regulates, and cooperates with transforming growth factor &bgr; signaling in SM differentiation of EPDCs. Conclusions: Notch signaling is a crucial regulator of SM differentiation of EPDCs, and thus, of formation of a functional coronary system.
Increased insulin secretion and decreased glucose concentrations, but not allostatic load, are associated with stress-related exhaustion in a clinical patient population

Allostatic load (AL) has been shown to be a useful marker of physiological strain during chronic stress and burnout in non-clinical working populations. The usability of the AL index for a clinical population with severe stress-related exhaustion was tested in this study. Thirteen biomarkers assembled as an AL index were analysed using blood samples from 90 patients with stress-related exhaustion (43 men and 47 women, age 31–61 years) and 90 healthy controls (46 men and 44 women, age 25–56 years). The AL scores did not differ between patients and controls. For men, some indication of higher cardiovascular risk was seen in the patient group: male patients had higher body mass index and waist–hip ratio and a poorer blood lipid status than male controls. We found lower plasma glucose concentrations in both female and male patients than those in controls. The male patients also showed increased fasting serum insulin concentrations. Further analysis using homeostasis model assessment for insulin resistance and β-cell function showed indications of insulin resistance in the patient group, particularly in the males, and an increased insulin secretion in both male and female patients. In conclusion, AL index does not seem to capture plausible physiological strain in patients diagnosed with stress-related exhaustion. The finding of lower plasma glucose concentrations, probably due to higher insulin secretion, in patients with severe stress-related exhaustion, needs to be further investigated, including mechanisms and the clinical relevance.
Cervical cancer incidence, mortality, and survival among Asian subgroups in California, 1990–2004

Aggregated cancer statistics for Asians mask important differences in cancer burden among Asian subgroups. The purpose of this study was to describe the relative patterns of cervical cancer incidence, mortality, and survival among Chinese, Filipino, Japanese, Korean, South Asian, and Vietnamese women in California, using data from the California Cancer Registry.
A hybrid deployment model for financial systems with Service Oriented Architecture (SOA): Running from Client via Branch Server

Applications which are the result of Software Development Life Cycle (SDLC) should be delivered to end users seamlessly. This delivery process which is named as deployment is therefore critical. Especially for systems with ongoing development and frequent deployments, this process should not take a lot of time and create a state of emergency. Also it is important that it is automatized and does not disrupt business continuity. Criticality of transactions increases the importance of deployment process for financial enterprises which are also required to have high performance systems and give uninterrupted service. In this study, deployment of critical financial systems with Service Oriented Architecture (SOA) is addressed and requirements of deployment process are described. Alternative deployment processes for SOA are discussed and compared, "Running from Client via Branch Server" model is proposed with its application architecture and principles of operation. It is shown that this model is the optimum deployment model in terms of performance and availability. The model is detailed in accordance with requirements of financial systems.
Problem solving therapy for subthreshold depression in home healthcare patients with cardiovascular disease.

BACKGROUND Randomized trial evaluated problem-solving therapy in home care (PSTHC) for homebound older adults with cardiovascular disease receiving acute home care services. This study hypothesized that compared with usual care plus education intervention, home-based PST-HC would significantly reduce depression and anxiety scores, lead to improved quality of life, and greater satisfaction with treatment among elderly with cardiovascular disease. METHODS Thirty-eight participants were recruited from a university-affiliated home healthcare agency for the trial. Six 1-hour PST-HC sessions included depression education, problem-solving skills, pleasurable activity scheduling, homework, and weekly telephone calls over a 6-week period. The control comparison group received usual care plus two sessions of education and a depression brochure. Outcome measures included the Beck Depression Inventory, Hamilton Rating Scale for Depression, Beck Anxiety Inventory, and the short form (SF)-36 health status measure. After the intervention, both groups completed the Patient Satisfaction Questionnaire. RESULTS Compared with the control group, the PST-HC group showed a significant decrease in depression but not anxiety scores. The PST-HC group generally reported more favorable satisfaction with treatment than the control group. The PST-HC group improved significantly, when compared with the control group in only two of eight SF-36 subscales: mental health and emotional role function. CONCLUSIONS The brief PST-HC intervention demonstrated that depression improved among home care elderly. However, there was no change in six of eight health status measures or anxiety level. Authors discuss integrating interdisciplinary depression care in the home care setting.
De Bruijn Graph based De novo Genome Assembly

The Next Generation Sequencing (NGS) is an important process which assures inexpensive organization of vast size of raw sequence data set over any traditional sequencing systems or methods. Various aspects of NGS like template preparation, sequencing imaging and genome alignment and assembly outlines the genome sequencing and alignment . Consequently, deBruijn Graph (dBG) is an important mathematical tool that graphically analyzes how the orientations are constructed in groups of nucleotides. Basically, de Bruijn graph describe the formation of the genome segments in a circular iterative fashions. Some pivotal de Bruijn graph based de novo algorithms and software package like T-IDBA, Oases, IDBA-tran, Euler, Velvet, ABySS, AllPaths, SOAPdenovo and SOAPdenovo2 have illustrated here. Next Generation Sequencing (NGS), deBruijn Graph (dBG), SOAPdenove2
Synthesis and Properties of Bis-Porphyrin Molecular Tweezers: Effects of Spacer Flexibility on Binding and Supramolecular Chirogenesis

Ditopic binding of various dinitrogen compounds to three bisporphyrin molecular tweezers with spacers of varying conformational rigidity, incorporating the planar enediyne (1), the helical stiff stilbene (2), or the semi-rigid glycoluril motif fused to the porphyrins (3), are compared. Binding constants Ka = 104–106 M−1 reveal subtle differences between these tweezers, that are discussed in terms of porphyrin dislocation modes. Exciton coupled circular dichroism (ECCD) of complexes with chiral dinitrogen guests provides experimental evidence for the conformational properties of the tweezers. The results are further supported and rationalized by conformational analysis.
A Multi-objective Decision Support Framework for Simulation-Based Security Control Selection

In this paper, we report on our ongoing research on simulation-based information security risk assessment and multi-objective optimization of investment in security controls. We outline a methodological framework that accounts for characteristics of the organization, its information infrastructure, assets to be protected, the particular threat sources it faces, and the decision-makers' risk preferences. This framework comprises (i) ontological modeling of security knowledge, (ii) dynamic attack graph generation techniques, (iii) probabilistic simulation of attacks by goal-driven threat agents, (iv) meta-heuristic identification of efficient portfolios of information security controls, and (v) interactive decision support. These components facilitate novel techniques to infer possible routes of attacks and generate attack graphs based on attackers' motivation, objectives, capabilities, and available modes of entry and to use this inferred knowledge to simulate attacks on an organization's modeled infrastructure. The method supports decision makers evaluating potential security control investments in striking a balance between monetary and non-monetary criteria regarding risks, costs, and benefits. We are currently in the process of developing a prototypical implementation of the framework that will be used to evaluate the approach through application case studies.
A fast trellis-based rate-allocation algorithm for robust transmission of progressively coded images over noisy channels

We propose a fast trellis-based rate-allocation algorithm for robust transmission of progressively coded images over noisy channels. The algorithm, which is an improved version of a similar algorithm by Banister et al., is based on the application of the Viterbi algorithm to a search trellis. This trellis is a substantially trimmed version of the one used by Banister et al. The proposed algorithm is applied to images encoded by the set partitioning in hierarchical trees and the Joint Photographers Expert Group 2000 for transmission over binary symmetric channels. For different total bit budgets and channel parameters, speed-up factors of up to about three orders of magnitude are achieved.
Structure-Activity Relationships of GPR120 Agonists Based on a Docking Simulation

GPR120 is a G protein-coupled receptor expressed preferentially in the intestinal tract and adipose tissue, that has been implicated in mediating free fatty acid-stimulated glucagon-like peptide-1 (GLP-1) secretion. To develop GPR120-specific agonists, a series of compounds (denoted as NCG compounds) derived from a peroxisome proliferator-activated receptor γ agonist were synthesized, and their structure-activity relationships as GPR120 agonists were explored. To examine the agonistic activities of these newly synthesized NCG compounds, and of compounds already shown to have GPR120 agonistic activity (grifolic acid and MEDICA16), we conducted docking simulation in a GPR120 homology model that was developed on the basis of a photoactivated model derived from the crystal structure of bovine rhodopsin. We calculated the hydrogen bonding energies between the compounds and the GPR120 model. These energies correlated well with the GPR120 agonistic activity of the compounds (R2 = 0.73). NCG21, the NCG compound with the lowest calculated hydrogen bonding energy, showed the most potent extracellular signal-regulated kinase (ERK) activation in a cloned GPR120 system. Furthermore, NCG21 potently activated ERK, intracellular calcium responses and GLP-1 secretion in murine enteroendocrine STC-1 cells that express GPR120 endogenously. Moreover, administration of NCG21 into the mouse colon caused an increase in plasma GLP-1 levels. Taken together, our present study showed that a docking simulation using a GPR120 homology model might be useful to predict the agonistic activity of compounds.
Dental implants placement in paranoid squizofrenic patient with obsessive-compulsive disorder: A case report

Background Paranoid schizophrenia is a mental illness that involves no observable anatomical alteration. Main characteristic affects the personality of the individual, as well as areas of his own psychology. Case Report A 33-year-old man with paranoid schizophrenia and obsessive-compulsive disorder in treatment with Haloperidol, Oxcarbazepine, Olanzapine and Seroquel is presented. Dental exploration showed widespread decay mostly cervical with numerous root fragments, agenesis of lateral incisors, impacted wisdom teeth, missing teeth and malocclusion. Treatment plan included restoration of teeth decay, extractions of root fragments and implant-supported prostheses in bilateral upper lateral incisors for aesthetics reason. A previous consultation with a psychiatric specialist was performed and no contraindication were observed. A preliminary radiological examination was performed previous dental treatment and implant placement. Due to patient refusal to replace dental abscenses with implants, inform consent was signed up from his parents. After local anesthesia, first implant was placed at upper right lateral positions (Straumann Bone Level Ø 3.3 mm, length 10 mm). Two weeks later a second implant was placed at upper left lateral position (Straumann Bone Level Ø 3.3 mm, length 12 mm). The patient showed no postoperative complications. After implant placement, the patient attended scheduled review appointments. The prosthesis was placed after a 3-month period of osseointegration. Conclusions Implant placement can be considered a suitable option for people with mental disorders. A previous consultation with psychiatric specialists for conducting a good patient management is necessaire. Key words:Paranoid schizophrenia, obsessive-compulsive disorder, dental implants.
Program Analysis Too Loopy? Set the Loops Aside

Among the many obstacles in efficient and sound program analysis, loops may be the most prevalent. In program analyses that traverse paths, loops introduce a variable, possibly infinite, number of paths. This paper looks at whether loops could be analyzed separately and replaced with a summary. First, the complexity of a loop is estimated by counting the paths through the body of the loop. 85% of the loops have fewer than ten paths and less than 1% have more than 10,000 paths. Second, the number of paths is computed by analyzing loops separately to assess the feasibility of such an analysis approach. While the number of paths is decreased in many cases, it is typically not sufficient for long, complex functions. Finally, loops are classified based on their stopping condition and further analyzed for programming elements that may make loop analysis more difficult. Nearly half of the loops are array traversals and over half of the loops contain a function call.
THE PROTECTIVE EFFECT OF REGULAR AEROBIC TRAINING ON DOXORUBICIN-INDUCED HEPATOTOXICITY IN RATS: THE INSULIN-LIKE GROWTH FACTOR SYSTEM

Article history: Received: 19 June 2013 Accepted: 21 Aug 2013 Available online: 14 Oct 2013 ZJRMS 2014; 16(12): 59-64 Background: The liver plays a central role in insulin-like growth factor (IGF) system homeostasis. We examine the protective aerobic training on the IGF system following doxorubicin (DOX) induced hepatotoxicity. Materials and Methods: In this experimental study 48 Wistar male rats (weighing 257±28 g) were divided into 6 groups: (1) control+placebo (2) control+DOX 10 mg/kg (3) control+DOX 20 mg/kg (4) training+placebo (5) training+DOX 10 mg/kg (6) training+DOX 20 mg/kg. Hepatotoxicity was induced by DOX (10 and 20 mg/kg). Rats in the 4, 5 and 6 groups performed treadmill running of 25 to 54 min/day and 15 to 20 m/min, 5 days/week for 3 weeks. Results: While, DOX 10 mg/kg administration result in an insignificant increase in IGF-1 and IGF-1/IGFBP-3 and an insignificant decrease in IGFBP-3, DOX 20 mg/kg administration caused a significant increase in IGF-1 and IGF-1/IGFBP-3, an insignificant decrease in IGFBP-3, as compared to the group 1. Three weeks of the endurance exercise resulted in a significant decrease of IGF-1 and IGF-1/IGFBP-3 levels, and significant increase in IGFBP-3, as compared to the group 1. Furthermore, after 3 weeks endurance training and DOX treatment with 10 mg/kg an insignificant decrease in IGF-1, an insignificant increase in IGFBP-3 and a significant decrease in IGF-1/IGFBP-3 were detected, in comparison to group 2. Conclusion: DOX hepatotoxicity is dose-dependent, acute administration of DOX 20 mg/kg caused an imbalance in the IGF system and protective aerobic training may improve DOX-induced hepatotoxicity by up-regulation of IGFBP3. Copyright © 2014 Zahedan University of Medical Sciences. All rights reserved.
Combination can be hard: approximability of the unique coverage problem

We prove semi-logarithmic inapproximability for a maximization problem called <i>unique coverage</i>: given a collection of sets, find a subcollection that maximizes the number of elements covered exactly once. Specifically, we prove <i>O</i>(1/ log<sup>σ(ε)</sup><i>n</i>) inapproximability assuming that NP ⊈ BPTIME(2<sup><i>n</i>ε</sup>) for some ε > 0. We also prove <i>O</i>(1/log<sup>1/3-ε</sup> <i>n</i>) inapproximability, for any ε > 0, assuming that refuting random instances of 3SAT is hard on average; and prove <i>O</i>(1/log <i>n</i>) inapproximability under a plausible hypothesis concerning the hardness of another problem, balanced bipartite independent set. We establish matching upper bounds up to exponents, even for a more general (budgeted) setting, giving an Ω(1/log <i>n</i>)-approximation algorithm as well as an Ω(1/log <i>B</i>)-approximation algorithm when every set has at most <i>B</i> elements. We also show that our inapproximability results extend to envy-free pricing, an important problem in computational economics. We describe how the (budgeted) unique coverage problem, motivated by real-world applications, has close connections to other theoretical problems including max cut, maximum coverage, and radio broad-casting.
A scalable representation towards attack graph generation

In todaypsilas large complex organizational network, security administration is a challenging task. The typical means by which an attacker breaks into a network is through a series of exploits, where each exploit in the series satisfies the pre-condition for subsequent exploits and makes a causal relationship among them. Such a series of exploit is called attack path and the set of all possible attack paths form an attack graph. However, the generated attack graphs by various previous approaches become too complicated to visually interpret and comprehend. Hence the proposed approach addresses the scalability issue of the attack graph generation through a generic attack path detection algorithm. This will reduce the generation of redundancy in attack graph, thus facilitating security management of an enterprise network.
Online Model-Based Behavioral Fuzzing

Fuzz testing or fuzzing is interface robustness testing by stressing the interface of a system under test (SUT) with invalid input data. It aims at finding security-relevant weaknesses in the implementation that may result in a crash of the system-under-test or anomalous behavior. Fuzzing means sending invalid input data to the SUT, the input space is usually huge. This is also true for behavioral fuzzing where invalid message sequences are submitted to the SUT. Because systems are getting more and more complex, testing a single invalid message sequence becomes more and more time consuming due to startup and initialization of the SUT. We present an approach to make the test execution for behavioral fuzz testing more efficient by generating test cases at runtime instead of before execution, focusing on interesting regions of a message sequence based on a previously conducted risk analysis and reducing the test space by integrating already retrieved test results in the test generation process.
Measurement of the charge asymmetry in B

Citation Aaij, R. et al. " Measurement of the Charge Asymmetry in B[superscript ±]K[superscript ±] and search for B[superscript ±][superscript ±] decays. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. a r t i c l e i n f o a b s t r a c t The CP-violating charge asymmetry in B ± → φ K ± decays is measured in a sample of pp collisions at 7 TeV centre-of-mass energy, corresponding to an integrated luminosity of 1.0 fb −1 collected by the LHCb experiment. The result is A CP (B ± → φ K ±) = 0.022 ± 0.021 ± 0.009, where the first uncertainty is statistical and the second systematic. In addition, a search for the B ± → φπ ± decay mode is performed, using the B ± → φ K ± decay rate for normalization. An upper limit on the branching fraction B(B ± → φπ ±) < 1.5 × 10 −7 is set at 90% confidence level. The weak-interaction B ± → φ K ± decay is governed by the b → sss transition. In the Standard Model (SM), it can only occur through loop diagrams (see Fig. 1), leading to a branching fraction of order 10 −5 [1]. Because the dominant amplitudes have similar weak phases, the CP-violating charge asymmetry, defined as (1) is predicted to be small in the SM, typically 1–2% with uncertainties of a few percent [2,3]. A significantly larger value would signal interference with an amplitude not described in the SM. The current experimental world average is A CP (B ± → φ K ±) = 0.10 ± 0.04 [1], dominated by a recent measurement from the BaBar Collaboration [4]. Large CP violation effects have been seen in some regions of the B ± → K + K − K ± phase space, but not around the φ resonance [5]. The B ± → φπ ± decay is another flavour-changing neutral current process, driven by the b → dss quark-level transition (see Fig. 1). The high suppression, due to the tiny product of the Cabibbo–Kobayashi–Maskawa matrix elements [6,7] and to the Okubo–Zweig–Iizuka (OZI) rule [8–10] associated with the creation of the colourless ss pair forming the φ meson, makes this rare loop decay a sensitive probe of the SM. Indeed, even a small non-SM amplitude, e.g. …