Miracle-dz/UniFAR-FTUs huggingface dataset:
FSMAC: A file system metadata accelerator with non-volatile memory

File system performance is dominated by metadata access because it is small and popular. Metadata is stored as block in the file system. Partial metadata update results in whole block read and write which amplifies disk I/O. Huge performance gap between CPU and disk aggravates this problem. In this paper, a file system metadata accelerator (referred as FSMAC) is proposed to optimize metadata access by efficiently exploiting the advantages of Nonvolatile Memory (NVM). FSMAC decouples data and metadata I/O path, putting data on disk and metadata on NVM at runtime. Thus, data is accessed in block from I/O bus and metadata is accessed in byte-addressable manner from memory bus. Metadata access is significantly accelerated and metadata I/O is eliminated because metadata in NVM is not flushed back to disk periodically anymore. A light-weight consistency mechanism combining fine-grained versioning and transaction is introduced in the FSMAC. The FSMAC is implemented on the basis of Linux Ext4 file system and intensively evaluated under different workloads. Evaluation results show that the FSMAC accelerates file system up to 49.2 times for synchronized I/O and 7.22 times for asynchronized I/O.
Assessment of Lower Limb Neuromuscular Control in Prepubescent Athletes

Background Although neuromuscular indices have been extensively studied in adolescents and adults, limited data exist for prepubescent children. Hypothesis No differences exist between prepubescent boys and girls in lower limb strength, symmetry on single-legged hop testing, and limb alignment during drop-jump testing. Study Design Cross-sectional study (prevalence); Level of evidence, 1. Methods The authors tested 27 female and 25 male athletes who were aged 9 to 10 years and matched for both body mass index and years of organized sports participation. In a drop-jump screening test, the distance between the right and left hips, knees, and ankles was measured as an indicator of lower limb axial alignment in the coronal plane. The distance between the knees and ankles was normalized by the hip separation distance. Quadriceps and hamstrings strengths were measured isokinetically at 180 deg/s. Lower limb symmetry was determined from 2 single-legged hop function tests. Results Boys demonstrated greater mean absolute and normalized knee and ankle separation distances on the drop-jump test. Even so, 76% of boys had a normalized knee separation distance of 60% or less of the hip separation distance, as did 93% of girls, indicating a distinctly valgus alignment. There were no differences between the sexes in quadriceps and hamstrings peak torques, hamstrings/quadriceps ratio, time to peak torque, total work, or lower limb symmetry values. Conclusions A high percentage of the prepubescent athletes studied had a distinctly valgus lower limb alignment during the drop-jump test and a lack of lower limb symmetry during the hop tests. These same indices have been hypothesized to increase the risk for knee ligament injuries in older athletes. Neuromuscular training may be needed to address these issues in children.
Position statement: Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement.

OBJECTIVE The objective of the study was to evaluate the current state of clinical assays for total and free testosterone. PARTICIPANTS The five participants were appointed by the Council of The Endocrine Society and charged with attaining the objective using published data and expert opinion. EVIDENCE Data were gleaned from published sources via online databases (principally PubMed, Ovid MEDLINE, Google Scholar), the College of American Pathologists, and the clinical and laboratory experiences of the participants. CONSENSUS PROCESS The statement was an effort of the committee and was reviewed in detail by each member. The Council of The Endocrine Society reviewed a late draft and made specific recommendations. CONCLUSIONS Laboratory proficiency testing should be based on the ability to measure accurately and precisely samples containing known concentrations of testosterone, not only on agreement with others using the same method. When such standardization is in place, normative values for total and free testosterone should be established for both genders and children, taking into account the many variables that influence serum testosterone concentration.
Structural Breaks in the Game

To search for eras in a sports league, we utilize time-series tests with structural breaks in Major League Baseball performance. Using data from 1871-2010, the mean and standard deviation of four different performance measures are examined. Throughout, rather than assume that a break point is known a priori, we identify breaks endogenously from the data. Perhaps most notable among our findings, we identify a deterministic trend in mean slugging percentage with breaks in 1921 and 1992. Interestingly, these years closely coincide with the early years of the free-swinging (Babe Ruth) era and the modern steroid era, respectively.
Sequential treatment of icotinib after first-line pemetrexed in advanced lung adenocarcinoma with unknown EGFR gene status.

BACKGROUND In non-small cell lung cancer (NSCLC), the well-developed epidermal growth factor receptor (EGFR) is an important therapeutic target. EGFR activating gene mutations have been proved strongly predictive of response to EGFR-tyrosine kinase inhibitors (TKI) in NSCLC. However, both in daily clinical practice and clinical trials, patients with unknown EGFR gene status (UN-EGFR-GS) are very common. In this study, we assessed efficacy and tolerability of sequential treatment of first-line pemetrexed followed by icotinib in Chinese advanced lung adenocarcinoma with UN-EGFR-GS. PATIENTS AND METHODS We analyzed 38 patients with advanced lung adenocarcinoma with UN-EGFR-GS treated with first-line pemetrexed-based chemotherapy followed by icotinib as maintenance or second-line therapy. RESULTS The response rates to pemetrexed and icotinib were 21.1% and 42.1%, respectively. The median overall survival was 27.0 months (95% CI, 19.7-34.2 months). The 12-month overall survival probability was 68.4%. The most common toxicities observed in icotinib phase were rashes, diarrheas, and elevated aminotransferase. Subgroup analysis indicated that the overall survival is correlated with response to icotinib. CONCLUSIONS The sequence of first-line pemetrexed-based chemotherapy followed by icotinib treatment is a promising option for advanced lung adenocarcinoma with UN-EGFR-GS in China.
Intravascular ultrasound analysis of small vessel lesions treated with the sparrow coronary stent system: Results of the CARE II trial

The aim of this study was to evaluate the Sparrow sirolimus‐eluting stent (Sparrow‐SES) against the Sparrow bare‐metal stent (Sparrow‐BMS) and conventional balloon‐expandable bare‐metal stent (BMS: Driver/Micro‐Driver® stent, Medtronic Vascular, Santa Rosa, CA).
The mortality of lead smelter workers: an update.

OBJECTIVES Mortality studies of lead workers have shown excesses of nonmalignant renal disease and cerebrovascular disease. Animal studies and one human study have shown excess kidney cancer. We have updated a mortality study of male lead smelter workers (n = 1990). METHODS An analysis was conducted using standard life table techniques. The updated analysis added 11 years of follow-up and 363 new deaths. RESULTS The original study had found elevated but nonsignificant risks for kidney cancer, stroke, and nonmalignant renal disease, probably attributable to lead exposure. Deaths from accidents and nonmalignant respiratory disease were significantly elevated, but probably not as a result of lead exposure. In the updated study, no new deaths from nonmalignant renal disease occurred (9 observed, standardized mortality ratio = 1.21). Three more deaths from kidney cancer were observed, yielding a standardized mortality ratio of 1.93 (9 observed, 95% CI = 0.88, 3.67), which increased for those who had worked in areas with the highest lead exposure (8 observed, standardized mortality ratio = 2.39, 95% CI = 1.03, 4.71). Cerebrovascular disease remained elevated for those with more than 20 years of exposure (26 observed, standardized mortality ratio = 1.41, 95% CI = 0.92, 2.07). CONCLUSIONS This cohort with high lead exposure showed a diminishing excess of death from nonmalignant renal disease, a continued excess from kidney cancer, and an excess of cerebrovascular disease only in those with longest exposure to lead.
The impact of Pleistocene glaciation across the range of a widespread European coastal species

There is a growing consensus that much of the contemporary phylogeography of northern hemisphere coastal taxa reflects the impact of Pleistocene glaciation, when glaciers covered much of the coastline at higher latitudes and sea levels dropped by as much as 150 m. The genetic signature of postglacial recolonization has been detected in many marine species, but the effects of coastal glaciation are not ubiquitous, leading to suggestions that species may intrinsically differ in their ability to respond to the environmental change associated with glacial cycles. Such variation may indeed have a biological basis, but apparent differences in population structure among taxa may also stem from our heavy reliance on individual mitochondrial loci, which are strongly influenced by stochasticity during coalescence. We investigated the contemporary population genetics of Syngnathus typhle, one of the most widespread European coastal fish species, using a multilocus data set to investigate the influence of Pleistocene glaciation and reduced sea levels on its phylogeography. A strong signal of postglacial recolonization was detected at both the northern and eastern ends of the species’ distribution, while southern populations appear to have been relatively unaffected by the last glacial cycle. Patterns of population variation and differentiation at nuclear and mitochondrial loci differ significantly, but simulations indicate that these differences can be explained by the stochastic nature of the coalescent process. These results demonstrate the strength of a multilocus approach to phylogeography and suggest that an overdependence on mitochondrial loci may provide a misleading picture of population‐level processes.
Making sense of mechanical vibration period with sub-millisecond accuracy using backscatter signals

Traditional vibration inspection systems, equipped with separated sensing and communication modules, are either very expensive (e.g., hundreds of dollars) and/or suffer from occlusion and narrow field of view (e.g., laser). In this work, we present an RFID-based solution, Tagbeat, to inspect mechanical vibration using COTS RFID tags and readers. Making sense of micro and high-frequency vibration using random and low-frequency readings of tag has been a daunting task, especially challenging for achieving sub-millisecond period accuracy. Our system achieves these three goals by discerning the change pattern of backscatter signal replied from the tag, which is attached on the vibrating surface and displaced by the vibration within a small range. This work introduces three main innovations. First, it shows how one can utilize COTS RFID to sense mechanical vibration and accurately discover its period with a few periods of short and noisy samples. Second, a new digital microscope is designed to amplify the micro-vibration-induced weak signals. Third, Tagbeat introduces compressive reading to inspect high-frequency vibration with relatively low RFID read rate. We implement Tagbeat using a COTS RFID device and evaluate it with a commercial centrifugal machine. Empirical benchmarks with a prototype show that Tagbeat can inspect the vibration period with a mean accuracy of 0.36ms and a relative error rate of 0.03%. We also study three cases to demonstrate how to associate our inspection solution with the specific domain requirements.
A Research on Electricity Generation from Wind Corridors of Pakistan (Two Provinces): A Technical Proposal for Remote Zones

The non-renewable energy resources are limited and depleting gradually. As such, energy security has attained the greatest amount of attention globally than ever before. In the meantime, energy crises are already affecting the developing countries such as Pakistan, even though one-third of the population of the country is not even not connected to the national electricity grid. The population with access to on-grid electricity is enduring load shedding of more than 12 h a day. This situation is alarming and require immediate attention is required so as to add alternative energy resources to the country, which has long been relying on imported fuels. It is, therefore, high time that the abundant potential in the renewable energy resources of Pakistan such as solar, wind, and biomass are harnessed. These renewable energy resources are economical and environmentally friendly, and thus considered as sustainable, and the utilization of these in meeting energy demands can help to conserve conventional resources early diminishing. This paper provides a detailed description of the energy consumption and load-shedding scenario in Pakistan thereby focusing specifically Sindh and Baluchistan provinces. Since, wind energy is considered one of the cost-effective renewable resources, six potential sites in these two provinces are considered in this study. These sites lie within 250 km of the southeastern and 800 km of the southwestern regions of Pakistan. One-year wind speed data have been reported for variable heights of these proposed sites which represent to have an annual average wind speed of 6.63 m/s and 5.33 m/s respectively. The power generation data for these location of two provinces is 7.653 GWh, and 5.456 GWh per annum respectively. This study also elaborates on the advantages and disadvantages of harvesting and installing the wind energy and provides a technical proposal for the generation of electricity from the wind in the selected remote zones which are off the national grid. The findings of this paper will help concerned government departments to devise appropriate policies and attract investment in the wind energy sector to eradicate the on-going electricity crisis.
Calculation of the Torque on a Permanent Magnet Rotating in a Conducting Tube

The aim of the present paper is to investigate the behavior of a permanent magnet rotating inside a conducting tube of finite length. Especially, the linearity of the dependence of the torque acting on the magnet due to the eddy currents induced in the tube on the number of revolutions per minute is of interest. The movement of the conductor relative to the magnet is taken into account by a Minkowsky transformation. The resulting non symmetrical equations system is solved by a biconjugate gradient method. The calculations have been verified by comparison with a time stepping method and with measurements
Regulation of human airway ciliary beat frequency by intracellular pH

pHi affects a number of cellular functions, but the influence of pHi on mammalian ciliary beat frequency (CBF) is not known. CBF and pHi of single human tracheobronchial epithelial cells in submerged culture were measured simultaneously using video microscopy (for CBF) and epifluorescence microscopy with the pH‐sensitive dye BCECF. Baseline CBF and pHi values in bicarbonate‐free medium were 7.2 ± 0.2 Hz and 7.49 ± 0.02, respectively (n= 63). Alkalization by ammonium pre‐pulse to pHi 7.78 ± 0.02 resulted in a 2.2 ± 0.1 Hz CBF increase (P < 0.05). Following removal of NH4Cl, pHi decreased to 7.24 ± 0.02 and CBF to 5.8 ± 0.1 Hz (P < 0.05). Removal of extracellular CO2 to change pHi resulted in similar CBF changes. Pre‐activation of cAMP‐dependent protein kinase (10 μm forskolin), broad inhibition of protein kinases (100 μm H‐7), inhibition of PKA (10 μm H‐89), nor inhibition of phosphatases (10 μm cyclosporin + 1.5 μm okadaic acid) changed pHi‐mediated changes in CBF, nor were they due to [Ca2+]i changes. CBF of basolaterally permeabilized human tracheobronchial cells, re‐differentiated at the air–liquid interface, was 3.9 ± 0.3, 5.7 ± 0.4, 7.0 ± 0.3 and 7.3 ± 0.3 Hz at basolateral i.e., intracellular pH of 6.8, 7.2, 7.6 and 8.0, respectively (n= 18). Thus, intracellular alkalization stimulates, while intracellular acidification attenuates human airway CBF. Since phosphorylation and [Ca2+]i changes did not seem to mediate pHi‐induced CBF changes, pHi may directly act on the ciliary motile machinery.
Correlates of invalid neuropsychological test performance after traumatic brain injury

Primary objective: To investigate external correlates of invalid test performance after traumatic brain injury, as assessed by the California Verbal Learning Test – Second Edition (CVLT–II) and Word Memory Test (WMT). Research design: Consecutive 2-year series of rehabilitation referrals with a diagnosis of traumatic brain injury (n = 87). Methods and procedures: Logistic regression analysis was used to determine which demographic and neurological variables best differentiated those with vs. without actuarial CVLT–II or WMT evidence for invalid responding. Main outcomes and results: Twenty-one participants (about 24%) performed in the invalid range. The combination of a premorbid psychiatric history with minimal or no coma was associated with an approximately four-fold increase in the likelihood of invalid performance. Conclusions: Premorbid psychosocial complicating factors constitute a significant threat to validity of neuropsychological test results after (especially mild) traumatic brain injury. At the same time, care should be taken to not routinely assume that all persons with mild traumatic brain injury and premorbid psychiatric histories are simply malingering. The WMT appears to be a promising instrument for the purpose of identifying those cases where neuropsychological test results are confounded by factors not directly related to acquired cerebral impairment.
Development of the Digital Arthritis Index, a Novel Metric to Measure Disease Parameters in a Rat Model of Rheumatoid Arthritis

Despite a broad spectrum of anti-arthritic drugs currently on the market, there is a constant demand to develop improved therapeutic agents. Efficient compound screening and rapid evaluation of treatment efficacy in animal models of rheumatoid arthritis (RA) can accelerate the development of clinical candidates. Compound screening by evaluation of disease phenotypes in animal models facilitates preclinical research by enhancing understanding of human pathophysiology; however, there is still a continuous need to improve methods for evaluating disease. Current clinical assessment methods are challenged by the subjective nature of scoring-based methods, time-consuming longitudinal experiments, and the requirement for better functional readouts with relevance to human disease. To address these needs, we developed a low-touch, digital platform for phenotyping preclinical rodent models of disease. As a proof-of-concept, we utilized the rat collagen-induced arthritis (CIA) model of RA and developed the Digital Arthritis Index (DAI), an objective and automated behavioral metric that does not require human-animal interaction during the measurement and calculation of disease parameters. The DAI detected the development of arthritis similar to standard in vivo methods, including ankle joint measurements and arthritis scores, as well as demonstrated a positive correlation to ankle joint histopathology. The DAI also determined responses to multiple standard-of-care (SOC) treatments and nine repurposed compounds predicted by the SMarTRTM Engine to have varying degrees of impact on RA. The disease profiles generated by the DAI complemented those generated by standard methods. The DAI is a highly reproducible and automated approach that can be used in-conjunction with standard methods for detecting RA disease progression and conducting phenotypic drug screens.
LTCC Out-of-Phase Filtering Power Divider Based on Multiple Broadside Coupled Lines

This paper presents a compact microwave out-of-phase filtering power divider in low-temperature co-fired ceramic (LTCC) technology. The proposed device is composed of three resonators and an isolation resistor. One resonator is symmetrically coupled with the other two by employing multiple broadside coupled lines. Utilizing the transmission line theory, the magnitude and phase characteristics are addressed. Theoretical analysis indicates the proposed circuit provides two signal paths with bandpass responses and 180° phase difference. Also, the realization of the isolation between two output ports is analyzed. For validation, a filtering power divider with out-of-phase outputs is designed, fabricated, and measured. It occupies a compact area of $3.1 \times 3.2 \times 1.6$ mm3. Comparisons of the measured and simulated results are presented to verify the theoretical method.
Pilot Study: Supplementing Surgical Training for Medical Students Using a Low-Cost Virtual Reality Simulator

The goal of this research is to evaluate the benefits of using a low-cost Virtual Reality (VR) surgical training platform in bridging the gap between early surgical skills and effective performance in more advanced training and clinical settings. The specific aim of this study is to design and evaluate the efficacy of a low-cost virtual reality system as a precursor to improving surgical skills for novice trainees. A summary of our VR training system is presented, and training results from three pre-med students and five residents in a medical school are discussed that show preliminary evidence of the efficacy of the system.
Detection of Enterococcus faecalis and Candida albicans in previously root-filled teeth in a population of Gujarat with polymerase chain reaction

Background: Micro-organisms are the primary causative agents of endodontic infections. Phenotype based procedures for bacterial identification has certain drawbacks especially, when investigating the microbiota of root-filled teeth. Thus, more sensitive methods like Polymerase chain reaction (PCR) can provide results that are more accurate and reliable for the microbial prevalence in the root filled teeth. Aim: In this study, we have investigated twenty symptomatic root-filled teeth with chronic apical periodontitis for the prevalence of Enterococcus faecalis and Candida albicans in the root filled teeth associated with symptomatic cases with or without periradicular lesions. Materials and Methods: Microbiological samples were taken from the canals immediately after removal of previous gutta percha cones using aseptic techniques. After removal of root canal filling, samples were obtained with paper points placed in the canal. Paper points were transferred to a cryotube containing “Tris EDTA” buffer and immediately frozen at −20°C. Results: By PCR amplification of the samples using taxon specific primers, E. faecalis was found to be prevalent species, detected in 65% of the cases and C. albicans was detected in 35% of cases. Conclusion: The results of the study shows that geographical influence and dietary factors might have some role to play in the prevalence of the species like C. albicans and presence of E. faecalis confirming the assertion of previous culture-dependent and independent approaches for the microbiological survey of root filled teeth.