Miracle-dz/UniFAR-FTUs huggingface dataset:
Product market competition, state-ownership, corporate governance and firm performance

Purpose - The purpose of this paper is to examine the association between firm performance and product market competition (PMC), and then examine the mitigation effect of corporate governance and/or state-ownership (SOEs) in the association between PMC and firm performance using Chinese listed firms. Design/methodology/approach - The authors consider three determinants of the PMC that affect the nature of competition, and use market concentration, product substitutability and market size as proxies for PMC. The authors construct a corporate governance index which measures the extent of board independence, monitoring strength of supervisory board over board of directors, and monitoring strength of board of directors over CEO. The authors use Tobin’s Q as a proxy for firm performance. The authors use a sample of 20,706 firm-year observations listed on the Chinese stock market between 2001 and 2016 to empirically investigate the research questions proposed in the paper. Findings - The authors find that higher PMC is associated with lower firm performance. The authors find that good corporate governance practices moderate the negative effect of higher PMC on firm performance. The association between higher PMC and lower performance is weaker for firms controlled by SOEs compared to non-SOEs. Further, the moderation effect of SOEs on the association between higher PMC and lower performance is more pronounced for firms with good corporate governance practices compared to firms with weak corporate governance practices. Originality/value - Extant studies investigating the relationship between PMC and corporate governance suggest an either complementary or substitution relationship in developed economies. Our study highlights the interactive role played by SOEs and good corporate governance practices in firm performance in highly competitive product markets in an emerging economy. The findings provide insightful information to regulators of other emerging countries that SOEs with good corporate governance practices can play an important role in the economy by mitigating the negative effect of higher PMC on firm performance.
Genetic mapping of bra genes affecting branched-chain amino acid transport in Pseudomonas aeruginosa

Pseudomonas aeruginosa PAO mutants defective in the transport systems for branched-chain amino acids were isolated and characterized. Two mutations in strains selected for trifluoroleucine resistance, braA300 and braB307, were mapped in the met-9020-dcu-9108 and the nar-9011-puuC10 region, respectively. The mutation loci in strains selected for azaleucine resistance, braC310 and bra-311 through bra-314, were all located near the fla genes, with an order of region I fla-bra-region II fla. Strains with braA300 showed a marked reduction in the high-affinity branched-chain amino acid transport system (LIV-I) and a considerable decrease in the lower-affinity system (LIV-II). Strains with braB307 were found to be defective in the LIV-II system. Strains selected for azaleucine resistance were all defective only in the LIV-I system and fell into three phenotypically distinct classes. Strains with braC310 produced a binding protein for leucine, isoleucine, valine, alanine, and threonine (LIVAT-BP) altered in binding ability, indicating that the braC gene is the structural one for the LIVAT-BP. Strains with bra-311 or bra-312 showed a complete loss of production of the LIVAT-BP. Strains with bra-313 or bra-314 produced normal levels of functional LIVAT-BP, suggesting that these mutations are located in a gene(s) other than braC.
Human platelets circulating in mice: applications for interrogating platelet function and survival, the efficacy of antiplatelet therapeutics, and the molecular basis of platelet immunological disorders

Summary. Herein we describe a novel animal model for examining the survival and function of human platelets following their circulation in non‐obese diabetic/severe combined immunodeficient mice. Resting human platelets in platelet‐rich plasma are introduced into the retro‐orbital plexus, where they are absorbed with high efficiency and circulate for up to 2 days, comprising 10–20% of total circulating platelets. During this period of time, the human platelets can be exposed to a number of biochemical and immunochemical reagents, including novel antithrombotic compounds, or human antiplatelet antibodies that have been implicated in platelet destruction, activation or clearance. Platelets can also be subjected to a variety of storage conditions before infusion, and their relative survival and function following storage and circulation compared. The ability to evaluate in living mice the in vivo function and survival of circulating human platelets may prove valuable for determining mechanisms of antibody‐mediated platelet passivation, and aid in the development of novel antiplatelet therapeutics.
Particulate β-glucan regulates the immunosuppression of granulocytic myeloid-derived suppressor cells by inhibiting NFIA expression

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of cells which comprise two subsets: granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (M-MDSCs). MDSCs involve in tumor-associated immune suppression by remarkably blocking effector T-cell activation and inducing expansion of regulatory T cells in the tumor microenvironment. The treatment that alters the suppression of MDSCs can effectively facilitate the antitumor immune responses. Recently, we showed that the whole β-glucan particles (WGPs) are capable of altering the suppression of MDSCs. However, the regulatory mechanism of MDSCs by WGP remains unknown. In this study, we found that the expression of nuclear factor I-A (NFIA), an integral transcriptional component of myeloid differentiation and lineage commitment, was inhibited by WGP in G-MDSCs. The effect of WGP on expression of NFIA was the c-jun molecule dependent via Dectin-1 pathway in vitro. Moreover, NFIA knockdown could alter the suppressive function of G-MDSCs, promote the antitumor immune responses and delay the tumor progression in tumor-bearing mice. Taken together, our results demonstrate a critical role of NFIA during WGP regulating the immunosuppression of G-MDSCs, with potential implications as an antitumor immune therapeutic approach.
Numerical and experimental evaluation of SAR hotspots for an endovascular stent graft at 1.5T and 3T

A comparative, qualitative study of a numerical evaluation of specific absorption rates and the experimental assessment of temperature rise near an endovascular stent graft is presented in this work. This comparison is performed at nominal static magnetic fields of 1.5 and 3 T, which correspond to operating frequencies of nominal 64 and 128 MHz, respectively. Each of the two stent modules consists of several metallic coaxial struts, spaced along their common axis and spread over the full length. The analysis shows patterns of temperature increase which correlate with the SAR values determined numerically.
Nanoparticle Fullerene (C60) demonstrated stable binding with antibacterial potential towards probable targets of drug resistant Salmonella typhi – a computational perspective and in vitro investigation

Salmonella typhi, a Gram negative bacterium, has become multidrug resistant (MDR) to wide classes of antibacterials which necessitate an alarming precaution. This study focuses on the binding potential and therapeutic insight of Nano-Fullerene C60 towards virulent targets of Salmonella typhi by computational prediction and preliminary in vitro assays. The clinical isolates of Salmonella typhi were collected and antibiotic susceptibility profiles were assessed. The drug targets of pathogen were selected by rigorous literature survey and gene network analysis by various metabolic network resources. Based on this study, 20 targets were screened and the 3D structures of few drug targets were retrieved from PDB and others were computationally predicted. The structures of nanoleads such as Fullerene C60, ZnO and CuO were retrieved from drug databases. The binding potential of these nanoleads towards all selected targets were predicted by molecular docking. The best docked conformations were screened and concept was investigated by preliminary bioassays. This study revealed that most of the isolates of Salmonella typhi were found to be MDR (p < .05). The theoretical models of selected drug targets showed high stereochemical validity. The molecular docking studies suggested that Fullerene C60 showed better binding affinity towards the drug targets when compared to ZnO and CuO. The preliminary in vitro assays suggested that 100 μg/L Fullerene C60 posses significant inhibitory activities and absence of drug resistance to this nanoparticle. This study suggests that Fullerene C60 can be scaled up as probable lead molecules against the major drug targets of MDR Salmonella typhi.
Elastofibromatous Changes in Tissues From Spinal Biopsies. A Degenerative Process Afflicting a Small but Important Subset Of Patients Operated for Spinal Canal Compression: Report of 18 Cases

Elastofibroma is a tumorlike lesion occurring usually in the subscapular region of elderly females. In this study, 18 cases of elastofibromatous tissue retrieved from the spinal canal were analyzed to elucidate its frequency and possible clinical associations. The patients included 8 men and 10 women with a mean age of 63.4 years (range, 40-84 years). The elastic nature of the material was confirmed by Weigert’s elastic stain and immunohistochemically. Elastofibroma was diagnosed in 6 patients, and elastofibroma-like tissue was found in 11 samples. The finding of elastofibromatous tissue was associated with clinical diagnosis of juxtaarticular cysts (3 cases), thickening of ligamentum flavum (4 cases), extradural expansion (2 cases), metastatic involvement of the dorsal spine (3 cases), and a vertebral fracture (1 case). Two cases were located above the transpedicular fixation. Elastofibromatous tissue may be found in approximately 2.6% of all spinal biopsies and it may take part in compression of spinal cord and nerve roots.
Seven-color time-resolved fluorescence hybridization analysis of human papilloma virus types.

Identification of human papilloma virus (HPV) types is important in order to determine the risk of cervical carcinoma in women. This requires a technique to probe individual samples for multiple virus specificities. Here we describe simultaneous multicolor analysis of amplification products for any of seven amplified HPV types 16, 18, 31, 33, 35, 39, and 45, associated with cancer of the cervix. A seminested polymerase chain reaction was performed in a single tube using a biotinylated inner primer. Sets of amplification products, immobilized on a 96-pronged manifold solid support, were rendered single stranded and probed with a mix of seven type-specific, differentially labeled oligonucleotides. These probes contained 10 or 20 lanthanide chelates at the 5' ends with seven distinct combinations of europium, terbium, and samarium ions. The seven viral strains were correctly identified by time-resolved fluorescence measurement of the specifically hybridized probes. Using this assay format, simultaneous detection of any of seven or even more target variants is possible.
Promoting Healthy Behaviors among Egyptian Mothers: A Quasi-Experimental Study of a Health Communication Package Delivered by Community Organizations

Decisions made at the household level, for example, to seek antenatal care or breastfeed, can have a direct impact on the health of mothers and newborns. The SMART Community-based Initiatives program in Egypt worked with community development associations to encourage better household decision-making by training community health workers to disseminate information and encourage healthy practices during home visits, group sessions, and community activities with pregnant women, mothers of young children, and their families. A quasi-experimental design was used to evaluate the program, with household surveys conducted before and after the intervention in intervention and comparison areas. Survey questions asked about women’s knowledge and behaviors related to maternal and newborn care and child nutrition and, at the endline, exposure to SMART activities. Exposure to program activities was high in intervention areas of Upper Egypt: 91% of respondents reported receiving home visits and 84% attended group sessions. In Lower Egypt, these figures were 58% and 48%, respectively. Knowledge of danger signs related to pregnancy, delivery, and newborn illness increased significantly more in intervention than comparison areas in both regions (with one exception in Lower Egypt), after controlling for child’s age and woman’s education; this pattern also occurred for two of five behaviors (antenatal care visits and consumption of iron-folate tablets). Findings suggest that there may have been a significant dose-response relationship between exposure to SMART activities and certain knowledge and behavioral indicators, especially in Upper Egypt. The findings demonstrate the ability of civil society organizations with minimal health programming experience to increase knowledge and promote healthy behaviors among pregnant women and new mothers. The SMART approach offers a promising strategy to fill gaps in health education and counseling and strengthen community support for behavior change.
Productivity patterns in the Italian manufacturing sector

We investigate the influence of the differences in sectoral composition of activities (regional specialization), and in productivity gaps that are uniform across sectors, in explaining the interregional inequality in aggregate productivities per worker in Italy. To this end, the region differential in output per worker is decomposed in terms of differences in sectoral productivity and in the industry mix by means of a modified shift-share approach proposed by Esteban (2000). The role of these determinants is then assessed in a Solow growth theory framework by introducing a SUR analysis. We apply our methodology to analyze the Italian economic development relative to the manufacturing sector. The analysis covers a thirty year period (1970-2000). It is argued that the existence of region-specific productivity differentials, uniform across sectors, explain a quite large share of differences in productivity per worker, but within the geographical areas very different productivity patterns emerge.
Complementarity between Solar and Wind Energy Potentials in Benin Republic

This paper presents a study to show the complementarity between solar and wind energy potentials in Benin Republic. Daily wind speed data in the coast of Cotonou city, precisely in Cadjehoun district, has been used to assess wind energy potential. Solar potential is evaluated using spatio temporal daily solar radiation data covering the country. In this research, we have found the locations offering optimal complementarity between solar and wind energy. The complementarity is measured with Pearson correlation coefficient, which is used as objective function to be minimized. The optimization method used is Particle Swarm Optimization (PSO), which has been implemented in Matlab®. We showed that an optimal complementarity is obtained between the coast of Cotonou in the ‘Littoral’ department and the central part of the country in the ‘Collines’ department.
The Control of a Bipedal Running Robot based on Output Zeroing considered Rotation of the Ankle Joint

For the bipedal robot, this paper investigates natural running motion like human running, without performing tracking control to the optimal trajectory of such a motion. The bipedal robot considered in this paper is planar and has revolute joints which actuate ankle, knee and hip. The running motion is assumed to consist of two successive phases which are composed of a flight phase and a stance phase: the flight phase where the bipedal robot floats, the stance phase where either a heel or a toe keeps contact with the ground. In order to realize the natural motion of the human, an output function which is easily understood in the physical aspect is designed on the basis of the human actual motion. Running motion of bipedal robot is generated autonomously by zero dynamics which appears by zeroing output function. Some parameters of this output function are re-configured online in order to suppress disturbance caused by unstable zero dynamics. Through a numerical simulation it is confirmed that running motion becomes stable
On the Definition of Diversity Order Based on Renyi Entropy for Frequency Selective Fading Channels

Outage probabilities are important measures of the performance of wireless communication systems, but to obtain outage probabilities it is necessary to first determine detailed system parameters, followed by complicated calculations. When there are multiple candidates of diversity techniques applicable for a system, the diversity order can be used to roughly but quickly compare the techniques for a wide range of operating environments. For a system transmitting over frequency selective fading channels, the diversity order can be defined as the number of multi-paths if multi-paths have all equal energy. However, diversity order may not be adequately defined when the energy values are different. In order to obtain a rough value of diversity order, one may use the number of multi-paths or the reciprocal value of the multi-path energy variance. Such definitions are not very useful for evaluating the performance of diversity techniques since the former is meaningful only when the target outage probability is extremely small, while the latter is reasonable when the target outage probability is very large. In this paper, we propose a new definition of diversity order for frequency selective fading channels. The proposed scheme is based on Renyi entropy, which is widely used in biology and many other fields. We provide various simulation results to show that the diversity order using the proposed definition is tightly correlated with the corresponding outage probability, and thus the proposed scheme can be used for quickly selecting the best diversity technique among multiple candidates.
A comparison of common screening methods for predicting aberrant drug-related behavior among patients receiving opioids for chronic pain management.

OBJECTIVE The ability to predict risk for violating opioid medication policies, known as aberrant drug-related behavior, is critical for providing optimal treatment. Many pain management centers measure risk using one of several partially validated measures: the Screener and Opioid Assessment for Patients with Pain (SOAPP), the Diagnosis, Intractability, Risk, and Efficacy inventory (DIRE), and/or the Opioid Risk Tool (ORT). However, little is known about how these measures compare with each other in predicting aberrant drug-related behavior and discontinuance of opioid pain medications. The current study aimed to address this research question. PATIENTS Participants were 48 patients who attended a pain management center in Tennessee but were later discontinued from opioids for aberrant drug-related behavior. Patients referred for opioid medication for pain management participated in a semi-structured clinical interview with the staff psychologist and completed the aforementioned measures. Patients generally returned to the pain clinic on a monthly basis for medication management. Results. Analyses compared the sensitivity of each self-report measure and the clinical interview in predicting discontinuance for aberrant drug-related behavior. RESULTS showed the highest sensitivity for the clinical interview (0.77) and the SOAPP (0.72), followed by the ORT (0.45) and the DIRE (0.17). Combining the clinical interview with the SOAPP increased sensitivity to 0.90. CONCLUSIONS Among patients who were discontinued from opioids for aberrant drug-related behaviors, the clinical interview and the SOAPP were most effective at predicting risk at baseline. Implications for future research and clinical practice are discussed.
An exploratory study of staff capture at the South African Inspectorate of Prisons

When prison inspectorates are co-opted or “captured” by those they are monitoring, their ability to bring transparency, accountability, and a human rights culture to prisons becomes harder. Using survey data from 102 staff at the South African Judicial Inspectorate of Prisons (JIOP), this exploratory study measured the severity of staff capture (i.e., they were not protecting the exclusive interests of prisoners) and potential correlates of capture. Overall, study participants exhibited significant levels of capture with ordinary least squares regression indicating higher levels of capture among staff that were African, thought about someday working for the Department of Correctional Services, felt powerless when prison officials ignored them, and if prison officials respected their work (ps < .05). Length of JIOP employment was not associated with capture. These findings suggest that the JIOP's policy of not renewing many staffs' three-year contracts could ironically be putting them at risk for capture.
Dissecting a Charged Network at the Active Site of Orotidine-5′-phosphate Decarboxylase*

The crystal structure of yeast orotidine-5′-phosphate decarboxylase in complex with the postulated transition state analog, 6-hydroxyuridine-5′-phosphate, reveals contacts between this inhibitor and a novel quartet of charged residues (Lys-59, Asp-91, Lys-93, and Asp-96) within the active site. The structure also suggests a possible interaction between O2 of the 6-hydroxyuridine-5′-phosphate pyrimidine ring and Gln-215. Here we report the results of mutagenesis of each of the charged active site residues and Gln-215. The activities of the Q215A and wild-type enzymes were equal indicating that any interactions between this residue and the pyrimidine ring are dispensable for efficient decarboxylation. For the D91A and K93A mutant enzymes, activity was reduced by more than 5 orders of magnitude and substrate binding could not be detected by isothermal calorimetry. For the D96A mutant enzyme, k cat was reduced by more than 5 orders of magnitude, and isothermal calorimetry indicated an 11-fold decrease in the affinity of this enzyme for the substrate in the ground state. For the K59A enzyme, k cat was reduced by a factor of 130, and K m had increased by a factor of 900. These results indicate that the integrity of the network of charged residues is essential for transition state stabilization.
Apoptosis, Chemoresistance, and Breast Cancer: Insights From the MCF-7 Cell Model System

The MCF-7 cell line was derived from a patient with metastatic breast cancer in 1970. Since then it has become a prominent model system for the study of estrogen receptor-positive breast cancer. With this model as a focus, this review summarizes important studies addressing tumor necrosis factor-α as a prototypical apoptosis-inducing cytokine in MCF-7 cells. Both survival and death receptor signaling pathways are discussed in terms of their role in chemotherapy-induced apoptosis as well as in chemoresistance. Novel therapeutic approaches to the treatment of breast cancer are proposed utilizing knowledge of these signaling pathways as targets. Specifically, ceramide metabolism is proposed as a novel target for chemosensitivity, perhaps combined with selective inhibitors of Bcl-2 or PI3K/Akt/nuclear factor-κB. Suggested areas of future research include translational studies manipulating candidate survival and death signaling pathways.