Miracle-dz/UniFAR-FTUs huggingface dataset:
Micromechanical Rate Integrating Gyroscope With Angle-Dependent Bias Compensation Using a Self-Precession Method

Toward the objective of direct angle measurement using a rate integrating gyroscope (RIG) without a minimum rate threshold and with performance limited only by electrical and mechanical thermal noise, in this paper, we present the implementation of a generalized electronic feedback method for the compensation of MEMS gyroscope damping asymmetry (anisodamping) and stiffness asymmetry (anisoelasticity) on a stand-alone digital signal processing platform. Using the new method, the precession angle-dependent bias error and minimum rate threshold, two issues identified by Lynch for a MEMS RIG [1] due to anisodamping are overcome. To minimize angledependent bias, we augment the electronic feedback force of the amplitude regulator with a non-unity gain output distribution matrix selected to correct for anisodamping. Using this method, we have decreased the angle-dependent bias error by a factor of 12, resulting in a minimum rate threshold of ~3 °/s. To further improve RIG performance, an electronically induced self-precession rate is incorporated and successfully demonstrated to lower the rate threshold.
Effects of Amprenavir on HIV-1 Maturation, Production and Infectivity Following Drug Withdrawal in Chronically-Infected Monocytes/Macrophages

A paucity of information is available on the activity of protease inhibitors (PI) in chronically-infected monocyte-derived macrophages (MDM) and on the kinetics of viral-rebound after PI removal in vitro. To fill this gap, the activity of different concentrations of amprenavir (AMP) was evaluated in chronically-infected MDM by measuring p24-production every day up to 12 days after drug administration and up to seven days after drug removal. Clinically-relevant concentrations of AMP (4 and 20 μM) drastically decreased p24 amount released from chronically-infected MDM from Day 2 up to Day 12 after drug administration. The kinetics of viral-rebound after AMP-removal (4 and 20 μM) showed that, despite an initial increase, p24-production over time never reached the level observed for untreated-MDM, suggesting a persistent intracellular drug activity. In line with this, after AMP-removal, human immunodeficiency virus 1 (HIV-1) infectivity and intracellular the p24/p55 ratio (reflecting virion-maturation) were remarkably lower than observed for untreated MDM. Overall, AMP shows high efficacy in blocking HIV-1 replication in chronically-infected MDM, persisting even after drug-removal. This highlights the role of protease inhibitors in preventing the establishment of this important HIV-1 reservoir, thus reducing viral-dissemination in different anatomical compartments.
Ten-Year Trend in Women's Reasons for Abstaining or Limiting Drinking: The 2000 and 2010 United States National Alcohol Surveys.

BACKGROUND Data on individual and cultural factors contributing to drinking can inform screening and brief intervention in clinical practice. Our aims were to examine 10-year trends in women's reasons for abstaining/limiting drinking and to document changes in associations with drinking status for population subgroups defined by race/ethnicity and age. MATERIALS AND METHODS Using repeated cross-sectional data from White, Black and Hispanic women in the 2000 and 2010 United States National Alcohol Surveys (combined N = 5501), population-weighted multiple linear and multinomial logistic regression models assessed changes in three reasons for abstaining or limiting drinking (health concerns, religious prohibition, and upsetting family or friends) and drinking status (past-year abstainer, low-risk drinker, or at-risk drinker), and their associations over time. RESULTS Adjusting for key demographics, reasons for limiting alcohol consumption declined in importance over time, with reductions in both health concerns and religious prohibition particularly noteworthy for older women of all three racial/ethnic backgrounds. Despite these reductions in importance, both health concerns and religious prohibition were most consistently associated with increased abstinence relative to low-risk drinking; these reasons were not strongly associated with at-risk drinking, however. CONCLUSIONS It is essential for healthcare providers and others to disseminate accurate information about the risks of drinking to counter cultural shifts that suggest greater acceptance of moderate-to-heavy drinking by women aged 40 and older.
Conserved Tryptophan Motifs in the Large Tegument Protein pUL36 Are Required for Efficient Secondary Envelopment of Herpes Simplex Virus Capsids

ABSTRACT Herpes simplex virus (HSV) replicates in the skin and mucous membranes, and initiates lytic or latent infections in sensory neurons. Assembly of progeny virions depends on the essential large tegument protein pUL36 of 3,164 amino acid residues that links the capsids to the tegument proteins pUL37 and VP16. Of the 32 tryptophans of HSV-1-pUL36, the tryptophan-acidic motifs 1766WD1767 and 1862WE1863 are conserved in all HSV-1 and HSV-2 isolates. Here, we characterized the role of these motifs in the HSV life cycle since the rare tryptophans often have unique roles in protein function due to their large hydrophobic surface. The infectivity of the mutants HSV-1(17+)Lox-pUL36-WD/AA-WE/AA and HSV-1(17+)Lox-CheVP26-pUL36-WD/AA-WE/AA, in which the capsid has been tagged with the fluorescent protein Cherry, was significantly reduced. Quantitative electron microscopy shows that there were a larger number of cytosolic capsids and fewer enveloped virions compared to their respective parental strains, indicating a severe impairment in secondary capsid envelopment. The capsids of the mutant viruses accumulated in the perinuclear region around the microtubule-organizing center and were not dispersed to the cell periphery but still acquired the inner tegument proteins pUL36 and pUL37. Furthermore, cytoplasmic capsids colocalized with tegument protein VP16 and, to some extent, with tegument protein VP22 but not with the envelope glycoprotein gD. These results indicate that the unique conserved tryptophan-acidic motifs in the central region of pUL36 are required for efficient targeting of progeny capsids to the membranes of secondary capsid envelopment and for efficient virion assembly. IMPORTANCE Herpesvirus infections give rise to severe animal and human diseases, especially in young, immunocompromised, and elderly individuals. The structural hallmark of herpesvirus virions is the tegument, which contains evolutionarily conserved proteins that are essential for several stages of the herpesvirus life cycle. Here we characterized two conserved tryptophan-acidic motifs in the central region of the large tegument protein pUL36 of herpes simplex virus. When we mutated these motifs, secondary envelopment of cytosolic capsids and the production of infectious particles were severely impaired. Our data suggest that pUL36 and its homologs in other herpesviruses, and in particular such tryptophan-acidic motifs, could provide attractive targets for the development of novel drugs to prevent herpesvirus assembly and spread.
Cognitive-Behavioral Treatment of Social Anxiety Disorder and Comorbid Paranoid Schizophrenia

We report on the cognitive-behavioral treatment (CBT) of a patient with comorbid social anxiety disorder (SAD), schizophrenia, and major depressive disorder, complicated by alcohol abuse. Symptoms included auditory hallucinations that commented on the patient’s behavior and paranoid thoughts. The paranoid symptoms affected his social interactions as this included the fear that his thoughts may be heard and judged by others. Therapeutic activities raised awareness as to how avoidance interferes with and perpetuates the cycle of depression and psychosis while maintaining symptoms of SAD. Psychoeducation was provided about factors that maintain social anxiety and increase social isolation. New skills were obtained by helping the patient discover alternative ways to view social situations, experimentation, and real-world application to disprove notions about others’ predicted behavior. Treatment led to a great reduction in social anxiety, depression, and suspicious thinking. This case study demonstrates that SAD symptoms in a patient experiencing psychosis can be effectively treated using CBT.
Social street view: blending immersive street views with geo-tagged social media

This paper presents an immersive geo-spatial social media system for virtual and augmented reality environments. With the rapid growth of photo-sharing social media sites such as Flickr, Pinterest, and Instagram, geo-tagged photographs are now ubiquitous. However, the current systems for their navigation are unsatisfyingly one- or two-dimensional. In this paper, we present our prototype system, Social Street View, which renders the geo-tagged social media in its natural geo-spatial context provided by immersive maps, such as Google Street View. This paper presents new algorithms for fusing and laying out the social media in an aesthetically pleasing manner with geospatial renderings, validates them with respect to visual saliency metrics, suggests spatio-temporal filters, and presents a system architecture that is able to stream geo-tagged social media and render it across a range of display platforms spanning tablets, desktops, head-mounted displays, and large-area room-sized curved tiled displays. The paper concludes by exploring several potential use cases including immersive social storytelling, learning about culture and crowd-sourced tourism.
Learning Joint Gaussian Representations for Movies, Actors, and Literary Characters

Understanding of narrative content has become an increasingly popular topic. However, narrative semantics pose difficult challenges as the effects of multiple narrative facets, such as the text, events, character types, and genres, are tightly intertwined. We present a joint representation learning framework for embedding actors, literary characters, movies, genres, and descriptive keywords as Gaussian distributions and translation vectors on the Gaussian means. The Gaussian variance naturally corresponds to actors' versatility, a central concept in acting. Our estimate of actors' versatility agree with domain experts' rankings 65.95% of the time. This is, to our knowledge, the first computational technique for estimating this semantic concept. Additionally, the model substantially outperforms a TransE baseline in prediction of actor casting choices.
Antiplatelet Therapy in Coronary Artery Disease: A Daunting Dilemma

Percutaneous coronary intervention (PCI) with stenting for the treatment of acute coronary syndrome (ACS) is the contemporary standard of care. Such treatment is followed by dual antiplatelet therapy (DAPT) comprising of aspirin and a P2Y12 inhibitor. The efficacy of this therapy has been well established but the optimal duration of DAPT remains elusive, and has thus far attracted a prodigious deal of scientific attention. The decision regarding DAPT duration can be clinically challenging in the modern era with the evolution of newer stents, more potent antiplatelet agents, and novel anticoagulant drugs in addition to an older patient population with multiple comorbidities. Major societal guidelines have emphasized comprehensive assessment of ischemic and bleeding risk, in turn recommending individualization of DAPT duration, thus encouraging “shared decision making”. The following review is aimed at critically evaluating the available evidence to help make these crucial clinical decisions regarding duration of DAPT and triple therapy.
A Review on Composite Papers of Graphene Oxide, Carbon Nanotube, Polymer/GO, and Polymer/CNT: Processing Strategies, Properties, and Relevance

ABSTRACT In this review, particular importance is given to the fabrication and properties of carbon nanotube and graphene oxide-based paper-like materials (buckypapers). Different strategies for the reduction and functionalization of graphene oxide were also discussed. The chemistry of buckypapers is conversed with special emphasis on structure and essential characteristics of buckypaper. Various techniques for buckypaper processing have been critically reviewed including significance of each method. Moreover, importance of polymer/graphene oxide and polymer/carbon nanotube composite papers has been highlighted. Due to outstanding physical, thermal, and electrical properties, polymer-based buckypapers are potentially important as nanofilters, fuel cell components, and miniaturization of electrical connections. GRAPHICAL ABSTRACT
The course of subjective sleep quality in middle and old adulthood and its relation to physical health.

OBJECTIVES Older adults more often complain about sleep disturbances compared with younger adults. However, it is not clear whether there is still a decline of sleep quality after age 60 and whether changes in sleep quality in old age are mere reflections of impaired physical health or whether they represent a normative age-dependent development. METHOD Subjective sleep quality and perceived physical health were assessed in a large sample of 14,179 participants (52.7% women; age range 18-85) from the German Socio-Economic Panel Study across four yearly measurement time points. RESULTS Subjective sleep quality linearly declined from young adulthood until age 60. After age 60, a transient increase in subjective sleep quality occurred that coincides with retirement. After age 66, subjective sleep quality appears to decrease again. Physical health prospectively predicted subjective sleep quality and vice versa. These relations were similar for participants aged over and under 60. DISCUSSION Around retirement, a transient increase in subjective sleep quality appears to occur, which might reflect a decrease in work-related distress. Perceived physical health appears to be important for subjective sleep quality in old adults but not more important than at younger age.
Cell viability assessed in a reproducible model of human osteoblasts derived from human adipose-derived stem cells

Human adipose tissue-derived stem cells (hASCs) have been subjected to extensive investigation because of their self-renewal properties and potential to restore damaged tissues. In the literature, there are several protocols for differentiating hASCs into osteoblasts, but there is no report on the control of cell viability during this process. In this study, we used osteoblasts derived from hASCs of patients undergoing abdominoplasty. The cells were observed at the beginning and end of bone matrix formation, and the expression of proteins involved in this process, including alkaline phosphatase and osteocalcin, was assessed. RANKL, Osterix, Runx2, Collagen3A1, Osteopontin and BSP expression levels were analyzed using real-time PCR, in addition to a quantitative assessment of protein levels of the markers CD45, CD105, STRO-1, and Nanog, using immunofluorescence. Rhodamine (Rho123), cytochrome-c, caspase-3, P-27, cyclin D1, and autophagy cell markers were analyzed by flow cytometry to demonstrate potential cellular activity and the absence of apoptotic and tumor cell processes before and after cell differentiation. The formation of bone matrix, along with calcium nodules, was observed after 16 days of osteoinduction. The gene expression levels of RANKL, Osterix, Runx2, Collagen3A1, Osteopontin, BSP and alkaline phosphatase activity were also elevated after 16 days of osteoinduction, whereas the level of osteocalcin was higher after 21 days of osteoinduction. Our data also showed that the cells had a high mitochondrial membrane potential and a low expression of apoptotic and tumor markers, both before and after differentiation. Cells were viable after the different phases of differentiation. This proposed methodology, using markers to evaluate cell viability, is therefore successful in assessing different phases of stem cell isolation and differentiation.
OPTIMUM VITAMIN NUTRITION FOR POULTRY

What quantities of supplemental vitamins should be provided to poultry diets? One suggestion would be to meet vitamin requirements based on the National Research Council (NRC), Agriculture Research Council (ARC) or other agency nutrient recommendations. A second choice would be to provide higher levels as recommended by Poultry Industry Groups. This review attempts first to dispel the concept that only meeting NRC requirements will provide poultry optimum production and health protection. Some Poultry Industry Groups are, while others are not, recommending optimum vitamin supplementation. Recent information on beneficial effects of optimum vitamin nutrition for poultry will be emphasized.
Descriptive epidemiology of changes in weight and weight-related behaviours of Australian children aged 5 years: two population-based cross-sectional studies in 2010 and 2015

Objective Over the past 10–15 years there has been substantial investment in New South Wales (NSW), Australia, to reduce child obesity through interventions in children aged 0–5 years. We report changes in weight and weight-related behaviours of 5-year-old children. Design Cross-sectional surveys conducted in 2010 and 2015. Setting NSW schools (2010 n=44; 2015 n=41) Participants Australian children in kindergarten (2010 n=1141 and 2015 n=1150). Outcome measures Change in anthropometry and indicators of diet, screen time, school travel and awareness of health recommendations. Additionally, we examined 2015 differences in weight-related behaviours by sociodemographic characteristics. Results Prevalence of overweight/obesity was 2.1% lower (adjusted OR (AOR) 0.83, 95% CI 0.67 to 1.04) and abdominal obesity 1.7% higher (AOR 1.35, 95% CI 0.93 to 1.98) in 2015 than 2010. Significant improvements in multiple weight-related behaviours were observed among children in the highest tertile of junk food consumption (AOR 0.63, 95% CI 0.50 to 0.80), rewarded for good behaviour with sweets (AOR 0.59, 95% CI 0.47 to 0.74) and had a TV in their bedroom (AOR 0.65, 95% CI 0.43 to 0.96). In 2015, children from low socioeconomic neighbourhoods and non-English-speaking backgrounds were generally less likely to engage in healthy weight-related behaviours than children from high socioeconomic status neighbourhoods and from English-speaking backgrounds. Children in these demographic groups were less likely to eat breakfast daily, have high junk food intake and eat fast food regularly. Children from rural areas tended to have healthier weight-related behaviours than children from urban areas. Conclusions There were significant positive changes in 5-year-old children’s weight-related behaviours but children from low socioeconomic neighbourhoods and from non-English-speaking backgrounds were more likely to engage in unhealthy weight-related behaviours than children from high socioeconomic neighbourhoods and English-speaking backgrounds. The findings indicate that there is a need to enhance population-level efforts and ensure community programmes are targeted and tailored to meet different subpopulation needs.
The tragedy of the biodiversity data commons: a data impediment creeping nigher?

Abstract Researchers are embracing the open access movement to facilitate unrestricted availability of scientific results. One sign of this willingness is the steady increase in data freely shared online, which has prompted a corresponding increase in the number of papers using such data. Publishing datasets is a time-consuming process that is often seen as a courtesy, rather than a necessary step in the research process. Making data accessible allows further research, provides basic information for decision-making and contributes to transparency in science. Nevertheless, the ease of access to heaps of data carries a perception of ‘free lunch for all’, and the work of data publishers is largely going unnoticed. Acknowledging such a significant effort involving the creation, management and publication of a dataset remains a flimsy, not well established practice in the scientific community. In a meta-analysis of published literature, we have observed various dataset citation practices, but mostly (92%) consisting of merely citing the data repository rather than the data publisher. Failing to recognize the work of data publishers might lead to a decrease in the number of quality datasets shared online, compromising potential research that is dependent on the availability of such data. We make an urgent appeal to raise awareness about this issue.
A Systems Modeling Approach to Forecast Corn Economic Optimum Nitrogen Rate

Historically crop models have been used to evaluate crop yield responses to nitrogen (N) rates after harvest when it is too late for the farmers to make in-season adjustments. We hypothesize that the use of a crop model as an in-season forecast tool will improve current N decision-making. To explore this, we used the Agricultural Production Systems sIMulator (APSIM) calibrated with long-term experimental data for central Iowa, USA (16-years in continuous corn and 15-years in soybean-corn rotation) combined with actual weather data up to a specific crop stage and historical weather data thereafter. The objectives were to: (1) evaluate the accuracy and uncertainty of corn yield and economic optimum N rate (EONR) predictions at four forecast times (planting time, 6th and 12th leaf, and silking phenological stages); (2) determine whether the use of analogous historical weather years based on precipitation and temperature patterns as opposed to using a 35-year dataset could improve the accuracy of the forecast; and (3) quantify the value added by the crop model in predicting annual EONR and yields using the site-mean EONR and the yield at the EONR to benchmark predicted values. Results indicated that the mean corn yield predictions at planting time (R2 = 0.77) using 35-years of historical weather was close to the observed and predicted yield at maturity (R2 = 0.81). Across all forecasting times, the EONR predictions were more accurate in corn-corn than soybean-corn rotation (relative root mean square error, RRMSE, of 25 vs. 45%, respectively). At planting time, the APSIM model predicted the direction of optimum N rates (above, below or at average site-mean EONR) in 62% of the cases examined (n = 31) with an average error range of ±38 kg N ha−1 (22% of the average N rate). Across all forecast times, prediction error of EONR was about three times higher than yield predictions. The use of the 35-year weather record was better than using selected historical weather years to forecast (RRMSE was on average 3% lower). Overall, the proposed approach of using the crop model as a forecasting tool could improve year-to-year predictability of corn yields and optimum N rates. Further improvements in modeling and set-up protocols are needed toward more accurate forecast, especially for extreme weather years with the most significant economic and environmental cost.
Hand Switching Costs are not Uniform Across Response Components

ABSTRACT We investigated the extent to which a complex finger sequence impacts on hand switching costs in a sequential action. Response component latencies (premotor, motor, and movement) were compared in no-switch (same finger performed the action of pressing and reaching) and switch conditions (pressing with one finger and completing the reaching action with the homologous finger from the other hand). Results showed that the switch condition presented longer latency for premotor and movement components. For the motor component, however, switch condition was faster. This expands the previous literature investigating switching costs using simple finger movements in more complex tasks. A mechanical explanation of the interplay between response subcomponents is provided to explain the inversion of response pattern for the motor component.