Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of Gene Expression Regulated by the ETV5 Transcription Factor in OV90 Ovarian Cancer Cells Identifies FOXM1 Overexpression in Ovarian Cancer

Epithelial ovarian cancer is the most lethal gynecologic malignancy and the fifth leading cause of cancer death in women in the Western world. ETS transcription factors have been implicated in the regulation of gene expression during a variety of biologic processes including cell growth and differentiation. We recently examined the role of the ETS transcription factor ETV5 in epithelial ovarian cancer and described ETV5 as being upregulated in ovarian tumor samples as compared with ovarian tissue controls. In ovarian cancer cells, we showed that ETV5 regulated the expression of cell adhesion molecules, enhancing ovarian cancer cell survival in anchorage-independent conditions and suggesting that it plays a role in ovarian cancer cell dissemination and metastasis into the peritoneal cavity. To understand the role of ETV5 transcription factor during ovarian cancer cell dissemination, we analyzed by gene expression microarray technology those genes whose expression was altered in an ovarian cancer cell line with a stable downregulation of ETV5. The analysis of the genes and signaling pathways under the control of ETV5 in OV90 cells has unraveled new signaling pathways that interact with ETV5, among them the cell-cycle progression and the TGFβ signaling pathway. In addition, we found that the downregulation of ETV5 reduced the expression of the oncogenic transcription factor FOXM1. Consistently, FOXM1 was overexpressed in ovarian tumor samples, and its transcriptional levels increased with ETV5 transcription in ovarian tumor samples. Moreover, FOXM1 expression levels increased with tumor grade, suggesting a role in the progression of ovarian cancer. Mol Cancer Res; 10(7); 914–24. ©2012 AACR.
Marital Violence in the Year before and after Spouse-Involved Alcoholism Treatment.

ABSTRACT The Conflict Tactics Scale questionnaire on marital violence was administered to 29 alcoholics and their wives at entry to, and 1 year after, completing a behavioral marital therapy (BMT) treatment program. In the year prior to BMT, prevalence rates of any violent act, of minor to moderate violent acts, and of severe violent acts were five to six times greater than 1985 national sample rates for both alcoholics and their wives. In the year after BMT, when the alcoholics' drinking and the couples' level of marital adjustment had improved significantly, hr3band-to-wife overall and moderate violence, although decrea.ed significantly in prevalence and frequency, remained significantly elevated relative to national norms. Husbands' severe violence, however, did not decrease significantly and the prevalence rate, although reduced by one-half, was still significantly elevated relative to national norms. Wife-to-husband violence after BMT was significantly decreased in prevalence or frequency and no longer significantly elevated relative to national norms for indices of overall, moderate, and severe violence, except for the specific act of threatening with a knife or gun, the prevalence of which did not change after BMT, but remained significantly higher than national norms. (Author/NB)
Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos

In most cells, the DNA damage checkpoint delays cell division when replication is stalled by DNA damage. In early Caenorhabditis elegans embryos, however, the checkpoint responds to developmental signals that control the timing of cell division, and checkpoint activation by nondevelopmental inputs disrupts cell cycle timing and causes embryonic lethality. Given this sensitivity to inappropriate checkpoint activation, we were interested in how embryos respond to DNA damage. We demonstrate that the checkpoint response to DNA damage is actively silenced in embryos but not in the germ line. Silencing requires rad-2, gei-17, and the polh-1 translesion DNA polymerase, which suppress replication fork stalling and thereby eliminate the checkpoint-activating signal. These results explain how checkpoint activation is restricted to developmental signals during embryogenesis and insulated from DNA damage. They also show that checkpoint activation is not an obligatory response to DNA damage and that pathways exist to bypass the checkpoint when survival depends on uninterrupted progression through the cell cycle.
Mechanical Imaging of the Breast

In this paper, we analyze the physical basis for elasticity imaging of the breast by measuring breast skin stress patterns that result from a force sensor array pressed against the breast tissue. Temporal and spatial changes in the stress pattern allow detection of internal structures with different elastic properties and assessment of geometrical and mechanical parameters of these structures. The method entitled mechanical imaging is implemented in the breast mechanical imager (BMI), a compact device consisting of a hand held probe equipped with a pressure sensor array, a compact electronic unit, and a touchscreen laptop computer. Data acquired by the BMI allows calculation of size, shape, consistency/hardness, and mobility of detected lesions. The BMI prototype has been validated in laboratory experiments on tissue models and in an ongoing clinical study. The obtained results prove that the BMI has potential to become a screening and diagnostic tool that could largely supplant clinical breast examination through its higher sensitivity, quantitative record storage, ease-of-use, and inherent low cost.
The Status and Management of Exotic and Invasive Species in National Wildlife Refuge Wilderness Areas

1 Corresponding author: vwright@fs.fed. us ABSTRACT: On behalf of the U.S. Fish and Wildlife Service (USFWS), we surveyed agency personnel in 2001 to assess the status and management of invasive plants, exotic animals, and exotic pathogens within the agency’s federally designated wilderness areas. We surveyed wilderness areas because they serve as important ecological reference points for natural systems due to their protected status. Respondents from 68 of the 70 USFWS wilderness areas completed the survey. Exotic animals were deemed a major problem (i.e., one of the top 10 management priorities) in 32% of the wilderness areas surveyed. Invasive plants were considered a major problem in 26% of the wilderness areas surveyed in the lower 48 states, but in none of Alaska’s 21 wilderness areas. In contrast, respondents considered an exotic pathogen to be a major problem in only one wilderness area. Respondents in three USFWS Regions reported relatively large numbers of invasive species in wilderness: Region 2 (Southwest), Region 4 (Southeast), and Region 6 (Mountain-Prairie). Systematic field surveys had been conducted for invasive plants in 19% of the wilderness areas, for exotic animals in 18% of the areas, and for exotic pathogens in 10% of the areas. Respondents commonly cited a lack of staff and/or funding as a barrier to the implementation of monitoring and management programs. Therefore, we offer several suggestions to improve the management of invasive and exotic species in wilderness that would require few additional resources to implement. To facilitate the monitoring of trends and communication among managers, we made the results available in an Internet-accessible database <http://leopold.wilderness. net/links.htm>.
Influence of the macromolecular form of a B cell epitope on the expression of antibody variable and constant region structure

We investigated the influence of the macromolecular form of an epitope on the structure of antibody variable and constant regions expressed by the B cell population participating in an immune response to that epitope. Hybridomas were constructed from strain A/J mice undergoing either primary or secondary immune responses to p-azophenylarsonate conjugated to Brucella abortus (Ars-Bruc). We determined the sequences of the V genes expressed by hybridomas selected on the basis of expression of a single VH gene segment known to encode a large family of anti-Ars antibodies. These sequences were compared with the sequences of V genes expressed by a previously characterized panel of hybridomas isolated in the same way during the primary and secondary responses of A/J mice to Ars-KLH. The repertoire of Ars-specific V domains expressed among primary and secondary hybridomas elicited with these two forms of Ars were similar, as were the differences between primary and secondary V region somatic mutational alteration and affinity for Ars. In contrast, predominant expression of IgG2 anti-Ars antibodies was elicited in the secondary Ars-Bruc response, whereas secondary anti-Ars antibodies elicited with Ars-KLH are predominantly IgG1. Thus, differences in the macromolecular form of Ars clearly influence the isotypic profile of the anti-Ars response, but the expression, diversification, and selection of V domains elicited with this hapten are not greatly affected by such differences. Our results suggest that while isotype regulation is highly perceptive of the macromolecular form of a B cell epitope, V region regulation is primarily influenced by the molecular structure of that epitope.
Out with the old in with the new: What gets missed when deploying new technologies in A&E

This paper presents a longitudinal study (over 4 months) of an AE an observation of the physical whiteboard usage and in-depth interviews with all users of both the traditional whiteboard usage and the replacement technology. The research was conducted with systems manager and all whiteboard users (i.e. nursing management, nurses, doctors, porters, and agency staff) across a spread of time-frames. Although the technology supported simple information requirements complex co-ordination, collaboration and awareness issues were left unsupported. The important role of a ‘pen-holder’ (information co-ordinator) was poorly supported by the replacement technology as was the task of annotating information with changing situations and needs. Specific deployment issues are derived from these findings that should guide designers when implementing technology replacements for current physical information formats (e.g. whiteboards, notice boards, shared paper notes).
Attention following traumatic brain injury: Neuropsychological and driving simulator data, and association with sleep, sleepiness, and fatigue

The objectives of this study were to compare individuals with traumatic brain injury (TBI) and healthy controls on neuropsychological tests of attention and driving simulation performance, and explore their relationships with participants’ characteristics, sleep, sleepiness, and fatigue. Participants were 22 adults with moderate or severe TBI (time since injury ≥ one year) and 22 matched controls. They completed three neuropsychological tests of attention, a driving simulator task, night-time polysomnographic recordings, and subjective ratings of sleepiness and fatigue. Results showed that participants with TBI exhibited poorer performance compared to controls on measures tapping speed of information processing and sustained attention, but not on selective attention measures. On the driving simulator task, a greater variability of the vehicle lateral position was observed in the TBI group. Poorer performance on specific subsets of neuropsychological variables was associated with poorer sleep continuity in the TBI group, and with a greater increase in subjective sleepiness in both groups. No significant relationship was found between cognitive performance and fatigue. These findings add to the existing evidence that speed of information processing is still impaired several years after moderate to severe TBI. Sustained attention could also be compromised. Attention seems to be associated with sleep continuity and daytime sleepiness; this interaction needs to be explored further.
Importance of Ideal Body Image, Self-Esteem and Depression in Females.

Dissatisfaction with body image among women has become a major psychological and physical contemporary problem. This study is among the few to empirically suggest that overall body satisfaction is strongly related to perceived discrepancy of one's body image from ideal societal standards of attractiveness. This study also identifies the personal importance of meeting these ideals (IMI) as a mediating variable between body satisfaction and either self-esteem or depression. The results indicated that body satisfaction was positively correlated with self-esteem and negatively correlated with depression scores in a sample of 164 undergraduate women. As predicted, low body satisfaction alone did not predict self-esteem and depression scores as strongly as when IMI was included as a predictor. The presence of IMI enhances our understanding of why not all women who are dissatisfied with their bodies inevitably display lowered self-ezteem and depression scores. (BF) *********************************************************************** * Reproductions supplied by EDRS are the best that can be made * * from the original document. * *********************************************************************** IMPORTANCE OF IDEAL BODY IMAGE, SELF-ESTEEM AND DEPRESSION IN FEMALES Susan Kohlruss Salem, Ph.D. Allana C. Elovson, Ph.D. "PERMISSION TO REPRODUCE THIS MATERIAL HAS BEEN GRANTED BY 5, K oln(ro5s 10 THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) U.S. DEPARTMENT OF EDUCATION Once of Educahonal Research and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) r This document haS been reproduced as reCerved trOrn Ine person or orgamzation Outzpnatmg a MmOr Changes have been made to unprove reproduct.on oualdy Points ot stew Or OptruOns Staled m thtsdOcti ment do not neCeSSardy represent othoal OERI posibon or pohCy Presented at 101st Annual Convention of the American Psychological Association at Toronto, Ontario, Canada, August 1993. August 22, 12:00-12:50 p.m. This article is based on research conducted by Susan Kohlruss Salem, Ph.D. for her doctoral dissertation in psychology at the California School of Professional Psychology, Los Angeles. We wish to acknowledge Linda R. Friar, Ph.D. and Cherie Snyder Anderson, Ph.D. for their input on the research and Nurith Chocorn, Ph.D. for her assistance in data collection. Currect affiliations of the authors are: Susan Kohlruss Salem Loyola Marymount University and Allana C. Elovson Santa Monica, California. Correspondence concerning this paper should be addressed to: Susan Kohlruss Salem, Ph.D., Counseling Services, Loyola Marymount University, Loyola Blvd. at West 80th Street Los Angeles, CA 90045, Phone: (310)338-2868 2 BEST COPY AVAILABLE
Is the strength of implicit alcohol associations correlated with alcohol-induced heart-rate acceleration?

BACKGROUND Heart rate (HR) acceleration during the ascending limb of the blood alcohol curve has proven to be a reliable measure of the sensitivity to the activating effects of alcohol. In this study, we investigated the correlation between an ethanol-induced cardiac change and the strength of implicit alcohol-related arousal and approach associations and attentional bias for alcohol-related stimuli in heavy drinkers. These 3 types of implicit alcohol-related cognitions have been proposed to reflect the strength of incentive sensitization that is experienced after repeated alcohol use. METHODS Forty-eight heavy drinking men performed a modified version of the Implicit Association Test (IAT) to measure their implicit alcohol arousal and approach-avoidance associations. A modified version of the emotional Stroop was used to measure attentional bias for alcohol-related stimuli (blocked and unblocked). Next, a high dose of alcohol (1.0 mL/kg body weight 95% USP alcohol) was administered in a short period of time. Resting baseline HR, blood alcohol concentrations, mood, and craving for alcohol were assessed before alcohol administration and for 2 hours post-alcohol consumption. RESULTS Contrary to our hypothesis, a negative association was found between implicit arousal associations and alcohol-induced HR change. This indicates that strong arousal associations were correlated with a decrease in alcohol-induced HR. Approach associations and attentional bias were not correlated with alcohol-induced HR change, but both were correlated positively with each other. CONCLUSIONS Alcohol-arousal associations and other implicit cognitions (attentional bias, approach associations) are not positively related to individual differences in the sensitivity to alcohol's activating effects, at least not in the present sample consisting primarily of family history-negative heavy drinkers.
Risk Associated with Bee Venom Therapy: A Systematic Review and Meta-Analysis

Objective The safety of bee venom as a therapeutic compound has been extensively studied, resulting in the identification of potential adverse events, which range from trivial skin reactions that usually resolve over several days to life-threating severe immunological responses such as anaphylaxis. In this systematic review, we provide a summary of the types and prevalence of adverse events associated with bee venom therapy. Methods We searched the literature using 12 databases from their inception to June 2014, without language restrictions. We included all types of clinical studies in which bee venom was used as a key intervention and adverse events that may have been causally related to bee venom therapy were reported. Results A total of 145 studies, including 20 randomized controlled trials, 79 audits and cohort studies, 33 single-case studies, and 13 case series, were evaluated in this review. The median frequency of patients who experienced adverse events related to venom immunotherapy was 28.87% (interquartile range, 14.57–39.74) in the audit studies. Compared with normal saline injection, bee venom acupuncture showed a 261% increased relative risk for the occurrence of adverse events (relative risk, 3.61; 95% confidence interval, 2.10 to 6.20) in the randomized controlled trials, which might be overestimated or underestimated owing to the poor reporting quality of the included studies. Conclusions Adverse events related to bee venom therapy are frequent; therefore, practitioners of bee venom therapy should be cautious when applying it in daily clinical practice, and the practitioner’s education and qualifications regarding the use of bee venom therapy should be ensured.
Local context templates for Chinese constituent boundary prediction

In this paper, we proposed a shallow syntactic knowledge description: constituent boundary representation and its simple and efficient prediction algorithm, based on different local context templates learned from the annotated corpus. An open test on 2780 Chinese real text sentences showed the satisfying results: 94% (92%) precision for the words with multiple (single) boundary tag output.
Long-latency TMS-evoked potentials during motor execution and inhibition

Transcranial magnetic stimulation (TMS) has often been used in conjunction with electroencephalography (EEG), which is effective for the direct demonstration of cortical reactivity and corticocortical connectivity during cognitive tasks through the spatio-temporal pattern of long-latency TMS-evoked potentials (TEPs). However, it remains unclear what pattern is associated with the inhibition of a planned motor response. Therefore, we performed TMS-EEG recording during a go/stop task, in which participants were instructed to click a computer mouse with a right index finger when an indicator that was moving with a constant velocity reached a target (go trial) or to avoid the click when the indicator randomly stopped just before it reached the target (stop trial). Single-pulse TMS to the left (contralateral) or right (ipsilateral) motor cortex was applied 500 ms before or just at the target time. TEPs related to motor execution and inhibition were obtained by subtractions between averaged EEG waveforms with and without TMS. As a result, in TEPs induced by both contralateral and ipsilateral TMS, small oscillations were followed by a prominent negative deflection around the TMS site peaking at approximately 100 ms post-TMS (N100), and a less pronounced later positive component (LPC) over the broad areas that was centered at the midline-central site in both go and stop trials. However, compared to the pattern in go and stop trials with TMS at 500 ms before the target time, N100 and LPC were differently modulated in the go and stop trials with TMS just at the target time. The amplitudes of both N100 and LPC decreased in go trials, while the amplitude of LPC decreased and the latency of LPC was delayed in both go and stop trials. These results suggested that TMS-induced neuronal reactions in the motor cortex and subsequent their propagation to surrounding cortical areas might change functionally according to task demand when executing and inhibiting a motor response.
LiDAR remote sensing of forest structure

Light detection and ranging (LiDAR) technology provides horizontal and vertical information at high spatial resolutions and vertical accuracies. Forest attributes such as canopy height can be directly retrieved from LiDAR data. Direct retrieval of canopy height provides opportunities to model above-ground biomass and canopy volume. Access to the vertical nature of forest ecosystems also offers new opportunities for enhanced forest monitoring, management and planning.
The Modification of Undesirable Attitudes and Classroom Behavior Through Constructive Use of Social Power in the School Peer Culture.

A student leadership program was implemented in an elementary school to increase the social value of constructive (appropriate) classroom behavior and to generate more positive pupil attitudes toward self and school. The specific aims of the intervention were to reduce the disruptive, negative behavior of some socially powerful students while increasing the rewards for more appropriate models and for teacher efforts to improve classroom climate. The Ss were low-income Black elementary students in grades 4, 5, and 6. Eight teachers and 280 peers identified 64 actual or potential social leaders who were randomly assigned to experimental or control conditions. Teachers classified the Ss as generally positive or negative in attitudes and behavior. The Leaders (experimental group) met with an advisor twice a week for four months to study school problems and to plan projects which might contribute to the development of a more harmonious and productive.learning environment. Daily'the Leaders implemented such projects as a Good Citizen Program, monitoring students, assisting administrators, and serving as teacher aides in kindergarten-primary classrooms. The effects of the intervention upon attitudes of Leaders were determined by measures of self-concept, locus of control, social efficacy, and attitudes toward school. Periodically, subject behavior was rated by teachers and coded by naive observers. Although ANOVA revealed few statistically significant changes in attitudes which were clearly related to the intervention, definite trends in the predicted directions were evident. Participation as Leaders did reduce the tendency of females and subjects with negative attitudes and behavior to become increasingly negative. Males, especially, increased their sense of efficacy and internal acceptance of responsibility. Leaders with teachers who were more supportive of the program often showed significant changes in attitudes and behavior. Experimental Ss' post-intervention self-reports on attitude measures were directly related to success as Leaders; i.e., the highest self-reports came from the most successful Leaders (as ranked by the experimenter). The most effective Leaders also tended to be those who ranked highest in peer nominations of social influence. The results indicate that a leadership program can help students improve their behavior and maintain or develop more positive self-perceptions.