Miracle-dz/UniFAR-FTUs huggingface dataset:
Growth-related changes in the inﬂuence of nitric oxide on arteriolar tone

and Growth-related changes in the inﬂuence of nitric oxide on arteriolar tone. Am. J. Physiol. 277 ( Heart Circ. Physiol. 46): H1570–H1578, 1999. —This study was designed to determine whether juvenile growth is accompanied by changes in the local inﬂuence of nitric oxide (NO) or prostaglandins on arteriolar tone. In vivo microscopy was used to study proximal arterioles in the spinotrapezius muscle of rats 4–5 wk (weanling), 7–8 wk (juvenile), and 11–12 wk (mature) of age. From 4 to 12 wk of age, arterioles underwent an increase in resting diameter (from 31 6 2 to 49 6 2 µm) and volume ﬂow (from 7 6 1 to 10 6 1 nl/s) but a decrease in resting wall shear rate (from 1,901 6 150 to 748 6 50 s 2 1 ). NO synthase inhibition with N G -monomethyl- L -arginine ( L -NMMA) had no effect on arteriolar diameters in weanling rats but reduced diameters by 14 6 4% in juvenile rats and by 13 6 4% in mature rats. Cyclooxygenase inhibition with meclofenamate reduced arteriolar diameters by a similar amount (13 6 4 to 18 6 3%) in all age groups. There were no age-related differences in arteriolar responsiveness to locally applied sodium nitroprusside or prostaglandin E 2 . Arteriolar responsiveness to ACh was also similar in all groups, but the L -NMMA-sensitive portion of this response was smaller in mature rats than in weanling rats. Elevation of ﬂow-related shear stress caused arteriolar dilation in juvenile rats but not in weanling rats. These ﬁndings suggest that arteriolar smooth muscle responsiveness to NO or prostaglandins does not change during juvenile growth and that basally released vasodilator prostaglandins exert a constant inﬂuence on arteriolar tone throughout this period. Basal NO activity also modulates arteriolar tone in juvenile and mature rats but not in weanling rats. In contrast, agonist-stimulated NO release is prominent in weanling and juvenile rats but somewhat decreased in mature rats, where cyclooxygenase products also contribute to ACh induced dilation. carried out using commercially available soft- ware (Sigma Stat, Jandel Scientiﬁc). Two-way ANOVA with one repeated factor (inhibitor treatment) was used to make simultaneous among-group comparisons for the effect of NO synthase inhibition on resting hemodynamic variables, arte- riolar responses to ACh, or arteriolar responses to SNP. This test was also used for among-group comparisons on the effect of L -NMMA and then L -NMMA 1 meclofenamate on arteriolar responses to ACh. Post hoc analysis was carried out using the Student-Newman-Keuls method, with signiﬁcance assessed at the 95% conﬁdence level ( P , 0.05) for all tests.
Regulated recycling and plasma membrane recruitment of the high‐affinity choline transporter

The high‐affinity choline transporter (CHT1) is responsible for uptake of choline from the synaptic cleft and supplying choline for acetylcholine synthesis. CHT1 internalization by clathrin‐coated vesicles is proposed to represent a mechanism by which high‐affinity choline uptake can be modulated. We show here that internalized CHT1 is rapidly recycled back to the cell surface in both human embryonic kidney cells (HEK 293 cells) and SH‐SY5Y neuroblastoma cells. This rapidly recycling pool of CHT1 comprises about 10% of total CHT1 protein. In the SH‐SY5Y neuroblastoma cell line K+‐depolarization promotes Ca2+‐dependent increase in the rate of CHT1 recycling to the plasma membrane without affecting the rate of CHT1 internalization. K+‐depolarization also increases the size of the pool of CHT1 protein that can be mobilized to the plasma membrane. Thus, the activity‐dependent increase in plasma membrane CHT1 localization appears to be regulated by two mechanisms: (i) an increase in the rate of externalization of the intracellular CHT1 pool; and (ii) the recruitment of additional intracellular transporters to the recycling pool.
The Nature and Origin of Common Phobic Fears

Summary By means of a twin study an attempt was made to throw light upon the aetiology and nosology of phobic fears. Factor analyses revealed five factors, namely separation fears, animal fears, mutilation fears, social fears and nature fears. The study demonstrated that, apart from separation fears, genetic factors play a part in the strength as well as content of phobic fears. Environmental factors, affecting the development of dependence, reserve and neurotic traits generally, seemed also to be of some importance. It was further demonstrated that phobic fears were related to emotional and social adjustment and this was true to an even greater extent for separation fears.
Spatio-temporal human action localisation and instance segmentation in temporally untrimmed videos

Current state-of-the-art human action recognition is focused on the classification of temporally trimmed videos in which only one action occurs per frame. In this work we address the problem of action localisation and instance segmentation in which multiple concurrent actions of the same class may be segmented out of an image sequence. We cast the action tube extraction as an energy maximisation problem in which configurations of region proposals in each frame are assigned a cost and the best action tubes are selected via two passes of dynamic programming. One pass associates region proposals in space and time for each action category, and another pass is used to solve for the tube's temporal extent and to enforce a smooth label sequence through the video. In addition, by taking advantage of recent work on action foreground-background segmentation, we are able to associate each tube with class-specific segmentations. We demonstrate the performance of our algorithm on the challenging LIRIS-HARL dataset and achieve a new state-of-the-art result which is 14.3 times better than previous methods.
Detective: Automatically identify and analyze malware processes in forensic scenarios via DLLs

Current memory forensic methods mainly focus on evidence collection and data recovery. A little work is about how to automatically identify malwares from many unknown processes and analyze their behaviors in high semantic level so as to collect related evidences. In fact, in real cases, investigators are often faced with large number of processes that they have no knowledge of. Although current malware detection tools could provide some help, they usually can't illustrate the purposes, abilities and behavior details of malwares and are thus often not fit for the forensic requirements. In this paper, we present a framework named Detective to cope with these issues. Given a set of unknown processes, Detective can classify benign and malware processes automatically. This is implemented by HNB classifying algorithm and a Dynamic-Link Libraries-based model. Detective could then explain malware behaviors in high semantic level through clustering and frequent item sets mining techniques. Besides, Detective sheds light on evidence collection by the information obtained from previous steps. Detective is applicable for both online and offline forensic scenarios. Experiments on real-world malware set have proved that the accuracy of Detective is above 90% and the time cost is only several seconds.
Abnormal Driving Detection Based on Normalized Driving Behavior

Abnormal driving behavior may cause serious danger to both the driver and the public. In this study, we propose to detect abnormal driving by analyzing normalized driving behavior. Serving as the virtual driver, a personalized driver model is established for speed control purposes by using the locally designed neural network and the real-world vehicle test data. The driving behavior is normalized by employing the virtual driver to conduct the speed following task as defined by the standard driving cycle test, e.g., the FTP-72. Three typical abnormal driving behaviors are characterized and simulated, namely, the fatigue/drunk, the reckless, and the phone use while driving. An abnormality index is proposed based on the analysis of normalized driving behaviors and is applied to quantitatively evaluate the abnormity. Numerical experiments are conducted to verify the effectiveness of the proposed scheme.
Genome Sequence of Porphyromonas gingivalis Strain AJW4

ABSTRACT Porphyromonas gingivalis is associated with oral and systemic diseases. Strain-specific P. gingivalis invasion phenotypes have been correlated with disease presentation in infected laboratory animals. Here, we present the genome sequence of AJW4, a minimally invasive strain, with a single contig of 2,372,492 bp and a G+C content of 48.27%.
Clathrin Light Chain: Importance of the Conserved Carboxy Terminal Domain to Function in Living Cells

Clathrin triskelions assemble into coats capable of packaging membrane and receptors for transport to intracellular destinations. A triskelion is formed from three heavy chains bound to three light chains. All clathrin light chains (clc) contain an acidic amino terminal domain, a central coiled segment, and a carboxy terminal domain conserved in amino acid sequence. To assess their functional contribution in vivo, we expressed tagged segments of the Dictyostelium clcA in clc‐minus Dictyostelium (clc null) cells. We examined the ability of these clcA fragments to rescue clathrin phenotypic deficiencies, to cluster into punctae on membranes, and to bind to the heavy chain. When expressed in clc null cells, a clcA fragment containing the amino terminal domain and the central coiled domain bound heavy chain but was dispensable for clathrin function. Instead, the carboxy terminal domain of clcA was a critical determinant for association with punctae, for clathrin function and for robust binding to the heavy chain. A 70 amino acid carboxy terminal fragment was necessary and sufficient for full function, and for localization into punctae on intracellular membranes. A shorter 49 amino acid carboxy terminal fragment could distribute into punctae but failed to rescue developmental deficiencies. These results reveal the importance of the carboxy terminal domain of the light chain in vivo.
Maximum achievable aspect ratio in deep reactive ion etching of silicon due to aspect ratio dependent transport and the microloading effect

When etching high-aspect-ratio silicon features using deep reactive ion etching (DRIE), researchers find that there is a maximum achievable aspect ratio, which we define as the critical aspect ratio, of an etched silicon trench using a DRIE process. At this critical aspect ratio, the apparent etch rate (defined as the total depth etched divided by the total elapsed time) no longer monotonically decreases as the aspect ratio increases, but abruptly drops to zero. In this paper, we propose a theoretical model to predict the critical aspect ratio and reveal its causal mechanism. The model considers aspect ratio dependent transport mechanisms specific to each of the reactant species in the three subprocesses of a time-multiplexed etch cycle: deposition of a fluorocarbon passivation layer, etching of the fluorocarbon polymer at the bottom of the trench, and the subsequent etching of the underlying silicon. The model predicts that the critical aspect ratio is defined by the aspect ratio at which the polymer etc.
A comparative study: verbal versus printed guiding grid

Assessment is a crucial part of education as it provides information to be used as feedback to support the teaching and learning process. Oral assessment is conducted at both primary and secondary schools in Malaysia. Previous researches highlight that students are unable to score well in their oral assessment. Therefore, the aim of this study is to examine the effectiveness of sharing assessment criteria, the Guiding Grid (GG), with students to improve oral performance among them. This study was conducted with Form Four students from an urban school. The students' oral assessments were conducted three times and their scores were recorded. The first assessment was done without sharing the GG with the students. Before the second assessment the researchers shared the GG verbally. Finally, 12 students who scored below the satisfactory level were given the printed GG and were assessed for the third time. The findings show a marked improvement in students' oral performance after the sharing of GG, orally as well as in print form. There is a significant improvement on the 12 selected students' oral performance when the printed GG was shared with them. This study also explores students' opinions on sharing the GG with them.
A question of competence.

Patients should be allowed to make decisions for themselves if they are mentally competent. However, the standards of mental competence vary, depending on aspects of the decision and on the patient. Decisions that are complex require a high level of competence. Decisions in which the consequences are severe may also require a high level of competence and require that the examiner is more certain about the level of competence that the patient exhibits. There are some decisions in which patients require specific cognitive attributes (such as long-term or short-term memory). We report our experience in dealing with an elderly woman who expressed a desire to return to her home after respite care, although evidence of self-neglect suggested that permanent placement in an aged-care hostel might be more appropriate.
Attitude Control of Quadrotor

This paper presents the attitude behaviour of quad-rotor by using a LQR controller. The performance of the LQR controller is compared to a PD controller. The controller is designed by using mathematical approaches and the results are obtained through the MATLAB simulations in the term of settling time and overshoot percentage.
The Fourier Theory of Vision

The historical roots of the Fourier theory of spatial visual perception are traced. The development of the underlying concepts and the psychophysical experiments that led to them, and that they in turn spawned, are examined, as well as their relation to the current knowledge of neural substrates in the retina and primary visual cortex. Allowing nonlinearities or even substituting other types of basis functions does not eliminate the difficulties faced by any theory of visual perception that is built on the notion of fixed spatial filters.
A novel Bayesian compressive sensing method for complex variables in SAR imaging

The complex multitask Bayesian compressive sensing (CMT-BCS) is well adaptive for sparse complex signal in low signal-to-noise ratio (SNR). However, the dimensions of measurement vector and dictionary matrix are double its original one with more iteration time. In this paper, we extend the Bayesian compressive sensing (BCS) reconstruction method to real and imaginary components with the phase estimation of scene in advance, and then combine the results of both real and imaginary components to optimize the final SAR image. Both the simulations and real experiments show that the proposed method can deal with complex sampling model effectively with the improvement of reconstruction precision. Comparing to the CMT-BCS, the dimensions of measurement vector and dictionary matrix will be reduced by half and the proposed method requires less running time and iterations.
Detailed molecular fingerprinting of four new anaplastic thyroid carcinoma cell lines and their use for verification of RhoB as a molecular therapeutic target.

CONTEXT Anaplastic thyroid carcinoma (ATC) is a highly aggressive carcinoma in need of therapeutic options. One critical component of drug discovery is the availability of well-characterized cell lines for identification of molecular mechanisms related to tumor biology and drug responsiveness. Up to 42% of human thyroid cancer cell lines are redundant or not of correct tissue origin, and a comprehensive analysis is currently nonexistent. Mechanistically, RhoB has been identified as a novel molecular target for ATC therapy. OBJECTIVE The aim was to develop four ATC cell lines detailing genetic, molecular, and phenotypic characteristics and to test five classes of drugs on the cell lines to determine whether they inhibited cell proliferation in a RhoB-dependent fashion. DESIGN Four cell lines were derived from ATC tumors. Short tandem DNA repeat and mutational status of the originating tumors and cell lines were performed along with molecular and phenotypic characterizations. Compounds were tested for growth inhibition and ability to up-regulate RhoB. RESULTS Cell line authenticity was confirmed by DNA short tandem repeat analysis. Each proved unique regarding expression of thyroid markers, oncogene status, amplified and deleted genes, and proliferative growth rates. FTI-277, GGTI-286, lovastatin, romidepsin, and UCN-01 up-regulated RhoB and inhibited cell proliferation in a dose-responsive fashion with only romidepsin and FTI-277 being RhoB dependent. CONCLUSIONS Molecular descriptions of thyroid lines were matched to the originating tumors, setting a new standard for cell line characterization. Furthermore, suppressed RhoB is implicated as a molecular target for therapy against ATC because five classes of drugs up-regulate RhoB and inhibit growth dose-responsively.
Self-reparable system on FPGA for single event upset recovery

Mission critical and reliable systems on FPGA require error mitigation and recovery techniques to protect them from the errors caused by high energy radiation also known as Single Event Upsets (SEU). Different solutions have been reported with different trade-off of area-overhead and fault latency. We propose a low area-overhead self-reparable procedure based on an internal error recovery mechanism, which is monitored by an external watchdog timer in the role of diagnostic hardcore. The proposed procedure has been verified by extensive fault emulation experiments.
Wireless networks: What next for radiowave propagation research

This paper chronicles the progress in wireless information transmission and reception, and discusses future trends in radiowave propagation research. Since the conception of wireless transmission, a number of pioneers have successfully understood and characterised the behaviour of narrowband, wideband and ultra-wideband signal transmission in a variety of environments and spectral regions. The physics of signal propagation mechanisms is now well understood and represented by deterministic and stochastic models. Frequency, spatial and polarisation properties of signal propagation have also been exploited. So are there any fundamental research problems left? The aim of this paper is to provoke discussion and debate so that the state-of-the-art of radiowave propagation is understood and further challenges are amassed.
Study of broadband circularly polarised microstrip antennas

In this paper, broadband and circular polarization techniques of Microstrip antenna (MSA) are studied. Microstrip antennas are suitable candidate for modern wireless communication. It possesses the advantages such as light weight, low cost and easy to fabricate, but they are inherence of bandwidth due to resonant nature. Several researchers attempted to overcome the above limitation. Also, MSA radiates naturally linearly polarized waves. Modern wireless communication requires circular polarization and wide bandwidth. In this context, several literature papers are available. The objective of the paper is to comprehensively study popular circular polarization and broadband techniques in MSA and sharing the knowledge to the new researchers in this field. Also, a design example is illustrated for broadband circularly polarized microstrip antenna.
High levels of Y-chromosome nucleotide diversity in the genus Pan

Although some mitochondrial, X chromosome, and autosomal sequence diversity data are available for our closest relatives, Pan troglodytes and Pan paniscus, data from the nonrecombining portion of the Y chromosome (NRY) are more limited. We examined ≈3 kb of NRY DNA from 101 chimpanzees, seven bonobos, and 42 humans to investigate: (i) relative levels of intraspecific diversity; (ii) the degree of paternal lineage sorting among species and subspecies of the genus Pan; and (iii) the date of the chimpanzee/bonobo divergence. We identified 10 informative sequence-tagged sites associated with 23 polymorphisms on the NRY from the genus Pan. Nucleotide diversity was significantly higher on the NRY of chimpanzees and bonobos than on the human NRY. Similar to mtDNA, but unlike X-linked and autosomal loci, lineages defined by mutations on the NRY were not shared among subspecies of P. troglodytes. Comparisons with mtDNA ND2 sequences from some of the same individuals revealed a larger female versus male effective population size for chimpanzees. The NRY-based divergence time between chimpanzees and bonobos was estimated at ≈1.8 million years ago. In contrast to human populations who appear to have had a low effective size and a recent origin with subsequent population growth, some taxa within the genus Pan may be characterized by large populations of relatively constant size, more ancient origins, and high levels of subdivision.
Factors influencing knowledge of and adherence to self-care among patients with heart failure.

BACKGROUND Patient education has been shown to be a key component in comprehensive heart failure management. Few data, however, are available regarding patients' knowledge of and adherence to self-care recommendations for the disease. OBJECTIVES To assess the knowledge level of and adherence to self-care among patients with heart failure and to determine associated factors. METHODS We conducted a needs-assessment survey among new patients visiting a heart failure clinic from April 1997 through June 1998. Multiple linear regression analysis was used to assess the factors predictive of patients' knowledge level and adherence behaviors. RESULTS Of the 113 patients surveyed, 77% were referred by cardiologists and 60% had New York Heart Association class III or IV status. Two thirds of the patients reported receiving information or advice about self-care from health care providers. When asked how much they knew about congestive heart failure, however, 37% said "a little or nothing," 49% said "some," and only 14% said "a lot. " Approximately 40% of the patients did not recognize the importance of weighing themselves daily and 27% weighed themselves twice a month or less often. Although 80% of the patients knew they should limit their salt intake, only one third always avoided salty foods. Additionally, 25% of the patients did not appreciate the risk of alcohol use and 36% believed they should drink a lot of fluids. The multiple linear regression analysis indicated that a higher knowledge score was associated with being married, prior hospitalization, and having received both advice and information about self-care from physicians or nurses. A poor adherence behavior score was associated with being unmarried, lower perceived self-efficacy, a lack of knowledge about self-care, and no prior hospitalization. CONCLUSIONS We observed a gap between patients receiving and absorbing or retaining information on self-care for congestive heart failure supplied by health care providers. Self-care education needs to be directed to outpatients in addition to inpatients.
Ju l 2 01 7 Secure SURF with Fully Homomorphic Encryption

Cloud computing is an important part of today’s world because offloading computations is a method to reduce costs. In this paper, we investigate computing the Speeded Up Robust Features (SURF) using Fully Homomorphic Encryption (FHE). Performing SURF in FHE enables a method to offload the computations while maintaining security and privacy of the original data. In support of this research, we developed a framework to compute SURF via a rational number based format compatible with FHE. Although floating point (R) to rational numbers (Q) conversion introduces error, our research provides tight bounds on the magnitude of error in terms of parameters of FHE. We empirically verified the proposed method against a set of images at different sizes and showed that our framework accurately computes most of the SURF keypoints in FHE.