Miracle-dz/UniFAR-FTUs huggingface dataset:
Characteristics of Bovine Lymphoma Caused by Bovine Leukemia Virus Infection in Holstein-Friesian Dairy Cattle in Korea

The frequency and distribution of lymphoma caused by bovine leukemia virus (BLV) infection in various organs were investigated. Lymphoma samples were obtained from slaughtered cattle or from cattle submitted to the National Veterinary Research and Quarantine Service, Korea. Thirty female Holstein-Friesian dairy cattle aged over three years with the BLV-associated lymphoma were studied. None of the Korean native cattle (Hanwoo) had lymphoma in this study however. Lymphoma tissues were gray to pink in color, soft in consistency, and bulged from the cut surface. In advanced lymphoma tissues, there was great variety in the appearance of involved structures due to hemorrhage, necrosis, and/or calcification. Neoplastic tissues were observed in lymph nodes in all lymphoma cases. Intestine (96.4%), heart (88.9%), stomach (73.1%), and diaphragm (62.5%) were frequently involved with lymphoma. However, there was no lymphoma detected in liver. Large neoplastic masses, sometimes reaching the size of over 20 cm, were found in the abdominal cavities. It is suggested that metastasis of lymphomas occurs mainly via lymph based on gross observations; neoplasia may have been initiated in the serosal surface of the lung, heart, peritoneum, and numerous hollow organs in the abdominal cavity. Also many organs in the abdominal and thoracic cavity were affected by neoplastic tissues simultaneously. Characteristics observed in this study could be used as criteria to differentiate BLV-associated lymphoma from other nodular lesions in the slaughterhouse and as fundamental data to make clear the mechanism of metastasis or pathogenesis of EBL.
Pulmonary Embolism Detection with Three-dimensional Ultrashort Echo Time MR Imaging: Experimental Study in Canines.

PURPOSE To demonstrate the feasibility of free-breathing three-dimensional (3D) radial ultrashort echo time (UTE) magnetic resonance (MR) imaging in the simultaneous detection of pulmonary embolism (PE) and high-quality evaluation of lung parenchyma. MATERIALS AND METHODS The institutional animal care committee approved this study. A total of 12 beagles underwent MR imaging and computed tomography (CT) before and after induction of PE with autologous clots. Breath-hold 3D MR angiography and free-breathing 3D radial UTE (1.0-mm isotropic spatial resolution; echo time, 0.08 msec) were performed at 3 T. Two blinded radiologists independently marked and graded all PEs on a four-point scale (1 = low confidence, 4 = absolutely certain) on MR angiographic and UTE images. Image quality of pulmonary arteries and lung parenchyma was scored on a four-point-scale (1 = poor, 4 = excellent). Locations and ratings of emboli were compared with reference standard CT images by using an alternative free-response receiver operating characteristic curve (AFROC) method. Areas under the curve and image quality ratings were compared by using the F test and the Wilcoxon signed-rank test. RESULTS A total of 48 emboli were detected with CT. Both readers showed higher sensitivity for PE detection with UTE (83% and 79%) than with MR angiography (75% and 71%). The AFROC area under the curve was higher for UTE than for MR angiography (0.95 vs 0.89), with a significant difference in area under the curve of 0.06 (95% confidence interval: 0.01, 0.11; P = .018). UTE image quality exceeded that of MR angiography for subsegmental arteries (3.5 ± 0.7 vs 2.9 ± 0.5, P = .002) and lung parenchyma (3.8 ± 0.5 vs 2.2 ± 0.2, P < .001). The apparent signal-to-noise ratio in pulmonary arteries and lung parenchyma was significantly higher for UTE than for MR angiography (41.0 ± 5.2 vs 24.5 ± 6.2 [P < .001] and 10.2 ± 1.8 vs 3.5 ± 0.8 [P < .001], respectively). The apparent contrast-to-noise ratio between arteries and PEs was higher for UTE than for MR angiography (20.3 ± 5.2 vs 15.4 ± 6.7, P = .055). CONCLUSION In a canine model, free-breathing 3D radial UTE performs better than breath-hold 3D MR angiography in the detection of PE and yields better image quality for visualization of small vessels and lung parenchyma. Free-breathing 3D radial UTE for detection of PE is feasible and warrants evaluation in human subjects.
T-cell recognition of a cross-reactive antigen(s) in erythrocyte stages of Plasmodium falciparum and Plasmodium yoelii: inhibition of parasitemia by this antigen(s)

In the current study, we investigated the presence of a cross-reactive antigen(s) in the erythrocyte stage from Plasmodium yoelii (265 BY strain) and Plasmodium falciparum through recognition by T cells primed in vivo with antigens from each of these parasites. BALB/c mice are naturally resistant to P. falciparum but are susceptible to P. yoelii infection. Mice that had recovered from P. yoelii primary infection became resistant to a second infection. A higher in vitro proliferative response to a soluble blood stage preparation of P. falciparum was observed in splenic cells from immune animals than in those from mice with a patent P. yoelii infection. The antigen-induced proliferative response was enhanced when animals were exposed to a secondary infection. Animals exposed to a challenge infection were treated with anti-CD4 or anti-CD8 monoclonal antibodies to deplete the corresponding subset of T cells. There was a marked diminution in P. falciparum antigen-induced proliferative response in the total splenic cell populations from CD8-depleted but not from CD4-depleted mice. In CD8-depleted and nondepleted animals, the antigen-induced proliferation in the total cell populations was markedly lower than in the T-cell-rich populations, indicating inhibitory activities of B cells and/or macrophages. There was no such difference in the stimulation between total and T-enriched cell populations from CD4-depleted animals. Flow cytometry analysis demonstrated the presence of an almost equal percentage of CD8+ (59.6%) and CD4+ (64%) T cells in the spleen preparations following in vivo depletion of CD4- and CD8-bearing T cells, respectively. When cultured with P. yoelii blood stage antigen, splenocytes from animals immunized with P. falciparum antigen displayed a significant proliferative response which was markedly diminished by treatment with anti-Thy-1.2 antibody plus complement. Animals immunized with P. falciparum antigen and then challenged with P. yoelii blood stage parasites displayed about a 50% lower level of parasitemia. These results demonstrated the existence of a cross-reactive antigen(s) between a murine and a human Plasmodium species, as determined from both in vivo and in vitro biological assays, and indicated the reactivity of mainly CD8+ T cells with this antigen.
Rigorous analysis of deformed nanowires using the multilevel fast multipole algorithm

We present accurate full-wave analysis of deformed nanowires using a rigorous simulation environment based on the multilevel fast multipole algorithm. Single nanowires as well as their arrays are deformed randomly in order to understand the effects of deformations to scattering characteristics of these structures. Results of hundreds of simulations are considered for statistically meaningful analysis of deformation effects. We show that deformations significantly enhance the forward-scattering abilities of single and arrays of nanowires, while the enhancement factor of an array depends on the number of elements.
Ferrite-based phase shifters design: The modeling problem of non-saturated anisotropic ferrites

Modeling the microwave behavior of ferrite in a non-saturated state is a burning issue for ferrite phase shifter designers. In this paper, a WR-90 waveguide loaded by a ferrite slab is studied. Classical simulations, using the Polder tensor, are not consistent with the measurements even in the case of a totally saturated state. An improvement was observed by using a generalized permeability tensor model, enhanced by taking into account an extra dynamic demagnetizing field.
Comparing the Cost of Care Provided to Medicare Beneficiaries Assigned to Primary Care Nurse Practitioners and Physicians.

OBJECTIVE This study is designed to assess the cost of services provided to Medicare beneficiaries by nurse practitioners (NPs) billing under their own National Provider Identification number as compared to primary care physicians (PCMDs). DATA SOURCE Medicare Part A (inpatient) and Part B (office visit) claims for 2009-2010. STUDY DESIGN Retrospective cohort design using propensity score weighted regression. DATA EXTRACTION METHODS Beneficiaries cared for by a random sample of NPs and primary care physicians. PRINCIPAL FINDINGS After adjusting for demographic characteristics, geography, comorbidities, and the propensity to see an NP, Medicare evaluation and management payments for beneficiaries assigned to an NP were $207, or 29 percent, less than PCMD assigned beneficiaries. The same pattern was observed for inpatient and total office visit paid amounts, with 11 and 18 percent less for NP assigned beneficiaries, respectively. Results are similar for the work component of relative value units as well. CONCLUSIONS This study provides new evidence of the lower cost of care for beneficiaries managed by NPs, as compared to those managed by PCMDs across inpatient and office-based settings. Results suggest that increasing access to NP primary care will not increase costs for the Medicare program and may be cost saving.
Cerebrospinal Fluid Tenascin-C in Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage

Background: Tenascin-C (TNC) has been reported to be a useful biomarker for the activity of inflammatory diseases. This study investigated the association between TNC levels in the cerebrospinal fluid (CSF) and symptomatic vasospasm after aneurysmal subarachnoid hemorrhage (SAH), and the prognostic value of TNC levels. Methods: TNC levels were measured in CSF in 33 consecutive patients diagnosed with aneurysmal SAH of Fisher computed tomography group III and were compared between those with and without subsequent cerebral vasospasm. Factors influencing symptomatic vasospasm were determined using multivariate logistic regression analyses. The receiver-operating characteristic curve technique was used to assess specificity and sensitivity in the prediction of symptomatic vasospasm. Results: The CSF TNC levels peaked immediately after SAH and were significantly higher in patients who subsequently developed symptomatic vasospasm than in those who did not. On multivariate analyses, higher TNC levels in the CSF (odds ratio, 1.059; 95% confidence interval, 1.023-1.096; P<0.001) and World Federation of Neurosurgical Societies grades IV to V on admission (odds ratio, 3.238; 95% confidence interval, 1.033-10.152; P<0.05) significantly predicted symptomatic vasospasm. To predict the onset of symptomatic vasospasm, 16.2 ng/mL was considered as an appropriate cut-off value for CSF TNC on days 1 through 6, giving a sensitivity of 81.0% and a specificity of 79.5% (negative and positive predictive values: 82.3% and 76.7%, respectively). Conclusions: TNC in the CSF may be a useful biomarker for predicting subsequent development of cerebral vasospasm.
Reduce the dimensions of emotional features by principal component analysis for speech emotion recognition

In this paper, the principal component analysis (PCA) is applied to speech emotion recognition for improving the accuracy of the system. The traditional prosodic features like pitch-related features and formant-related features are extracted from the Berlin speech database [7] and a Chinese database. These collected feature data is processed by PCA to remove the irrelevant information. After that, three kinds of features including the processed features by PCA, unprocessed features and other speech-related features are used to train a SVM classifier. And six emotions are tested in the experiment. The classification accuracy of the processed features by PCA is about 3.1% higher than the unprocessed features and about 17.6% higher than the MFCC features when using 240 utterances. The recognition accuracies among different emotions in both databases are also presented in the study.
Semaphorin 4D levels in heart failure patients: a potential novel biomarker of acute heart failure?

Semaphorin 4D (Sema4D) is expressed on platelets and T‐cells and known to be involved in inflammation. The aims of this study include comparing Sema4D and N terminal pro brain natriuretic peptide (NT‐proBNP) serum levels in heart failure (HF) patients to a control group, evaluating the correlation between Sema4D and NT‐proBNP levels, and assessing Sema4D serum levels in HF patients during acute exacerbation and remission.
Fatal Toxic Leukoencephalopathy Secondary to Overdose of a New Psychoactive Designer Drug 2C-E (“Europa”)

We present a case of a fatal toxic leukoencephalopathy following ingestion of a new psychoactive designer drug known as 2C-E or “Europa. ” Recreational drugs, particularly hallucinogenic substances, appear to be growing in popularity, with increasing amounts of information available via the Internet to entice potential users. In addition, some newer “designer” psychoactive substances are available for purchase online without adverse legal consequences, therefore adding to their popularity. We describe magnetic resonance imaging (MRI) findings to include selective diffuse toxic injury of the cerebral white matter with sparing of the cortex and most of the deep gray nuclei. To our knowledge, this is the first reported description of cerebral findings on MRI that are likely related to a lethal ingestion of 2C-E.
Alteromonas confluentis sp. nov., isolated from the junction between the ocean and a freshwater spring.

A Gram-stain-negative, aerobic, non-spore-forming, non-flagellated and coccoid, ovoid or rod-shaped bacterial strain, DSSK2-12T, was isolated from the place where the ocean and a freshwater spring meet at Jeju island, South Korea. Strain DSSK2-12T grew optimally at 30 °C, at pH 7.0–8.0 and in the presence of 2.0 % (w/v) NaCl. The neighbour-joining phylogenetic tree based on 16S rRNA gene sequences revealed that strain DSSK2-12T fell within the clade comprising the type strains of species of the genus Alteromonas. Strain DSSK2-12T exhibited 16S rRNA gene sequence similarity values of 97.2–98.1 % to the type strains of Alteromonas litorea, Alteromonas marina, Alteromonas hispanica and Alteromonas genovensis and of 95.39–96.98 % to those of other species of the genus Alteromonas. Strain DSSK2-12T contained Q-8 as the predominant ubiquinone and summed feature 3 (C16 : 1ω7c and/or C16 : 1ω6c), C16 : 0 and C18 : 1ω7c as the major fatty acids. The major polar lipids of strain DSSK2-12T were phosphatidylethanolamine, phosphatidylglycerol and one unidentified aminolipid. The DNA G+C content of strain DSSK2-12T was 48.6 mol% and its mean DNA–DNA relatedness values with the type strains of A. litorea, A. marina, A. hispanica and A. genovensis were 9–21 %. The differential phenotypic properties, together with phylogenetic and genetic distinctiveness, revealed that strain DSSK2-12T is separated from other species of the genus Alteromonas. On the basis of the data presented, strain DSSK2-12T is considered to represent a novel species of the genus Alteromonas, for which the name Alteromonas confluentis sp. nov. is proposed. The type strain is DSSK2-12T ( = KCTC 42603T = CECT 8870T).
Future Climates from Bias-Bootstrapped Weather Analogs: An Application to the Yangtze River Basin

Abstract The authors describe a statistical analog resampling scheme, similar to the “intentionally biased bootstrap,” for future climate projections whose only constraint is a prescribed linear temperature trend. It provides a large ensemble of day-to-day time series of single-station weather variables and other climatological observations at low computational cost. Time series are generated by mapping time sequences from the observed past into the future. The Yangtze River basin, comprising all climatological subregions of central China, is used as a test bed. Based on daily station data (1961–2000), the bootstrap scheme is assessed in a cross-validation experiment that confirms its applicability. Results obtained for the projected future climates (2001–40) include climatological profiles along the Yangtze, annual cycles, and other weather-related phenomena (e.g., floods, droughts, monsoons, typhoons): (i) the annual mean temperature and, associated with that, precipitation increase; (ii) the annual cyc.
Multi-task learning with application to water quality monitoring

Multi-task learning (MTL) exhibits improved performance in many problems in reality by utilizing the intrinsic features among multiple related tasks. In this paper, the problem of water quality monitoring is considered as multi-task learning, in which different tasks correspond to changes caused by new environment or different spectrometers. An improved learning model is presented describing the relationship between wavelengths and pollutant concentration as well as capturing the task relationships with a low-rank shared structure. Under the assumption that different tasks share some common wavelengths, an optimization problem is proposed with the predictors affected by these features and their corresponding coefficients that vary in different tasks. An alternating minimization algorithm is proposed to solve this problem. Experimental results demonstrate the effectiveness of the proposed algorithm in application.
Nonlinearity analysis in CMOS triode transconductor at low and high frequency

In this paper nonlinearity of triode transconductor (TC) based on Taylor series at low frequency and Volterra series at high frequency are presented. Unfortunately, Taylor series does not predict the frequency-dependent linearity degradation due to parasitic capacitors. Frequency dependence nonlinearity analysis in this structure gives more intuition about distortion mechanism that necessary for properly design linearized TCs at high frequency. In this paper, we present a frequency-dependent harmonic-distortion and intermoulation-distiortion analytical method applied to triode cascode TC. Analytical results are compared with simulation results and the effects of circuit parameters and frequency on linearity of triode cascade TCs are formulated.
MicroRNA dysregulation in rhabdomyosarcoma: a new player enters the game

Rhabdomyosarcoma (RMS) is the most common of the soft tissue sarcomas with resultant high morbidity, frequently occuring in paediatric patients and young adults. While the molecular basis of RMS has received considerable attention, exact mechanisms underlying its development and metastasis remain unclear. MicroRNAs (miRNAs) are endogenously expressed small non‐coding RNAs that negatively regulate gene expression via translational inhibition or mRNA degradation. Deregulated expression of miRNA has been implicated in initiation, progression, and metastasis of RMS. miRNAs have emerged as key regulators of several physiological and pathophysiological processes and have opened new avenues for diagnosis and treatment of RMS. This review summarizes deregulation and functional roles of miRNAs in RMS and their potential applications for diagnosis, prognosis and treatment of this malignancy. As a rapidly evolving field in basic and translational medicine, it is hopeful that miRNA research will ultimately improve management of RMS.
Variable dose analysis: A novel RNAi-based method for detection of synthetic lethal interactions

Synthetic sick or synthetic lethal (SS/L) screens are a powerful way to identify candidate drug targets to specifically kill tumor cells but such screens generally suffer from low reproducibility. We found that many SS/L interactions involve essential genes and are therefore detectable within a limited range of knockdown efficiency. Such interactions are often missed by overly efficient RNAi reagents. We therefore developed an assay that measures viability over a range of knockdown efficiency within a cell population. This method, called variable dose analysis (VDA), is highly sensitive to viability phenotypes and reproducibly detects SS/L interactions. We applied the VDA method to search for SS/L interactions with TSC1 and TSC2, the two tumor suppressors underlying tuberous sclerosis complex (TSC) and generated a SS/L network for TSC. Using this network, we identified four FDA-approved drugs that selectively affect viability of TSC deficient cells, representing promising candidates for repurposing to treat TSC-related tumors.
THE USE OF SOCIAL SURVEYS IN TRANSLATION STUDIES. METHODOLOGICAL CHARACTERISTICS

Translation is an activity carried out by professionals – in some cases after a period of formal training – who are employed or self-employed, and whose work is destined for translation users. Translators, translator trainees, employers of translators, and translation users are four clearly defined social groups within the translation industry that may be the subject of study using one of the methods most frequently used within the field of social sciences: the social survey. This paper presents the characteristics of the social survey methodology. It also analyses and evaluates the use of social surveys in the field of Translation Studies when preparing to introduce changes in academic curricula, defining professional competencies or obtaining opinions regarding the quality of interpreting and subtitling.
Style2Vec: Representation Learning for Fashion Items from Style Sets

With the rapid growth of online fashion market, demand for effective fashion recommendation systems has never been greater. In fashion recommendation, the ability to find items that goes well with a few other items based on style is more important than picking a single item based on the user's entire purchase history. Since the same user may have purchased dress suits in one month and casual denims in another, it is impossible to learn the latent style features of those items using only the user ratings. If we were able to represent the style features of fashion items in a reasonable way, we will be able to recommend new items that conform to some small subset of pre-purchased items that make up a coherent style set. We propose Style2Vec, a vector representation model for fashion items. Based on the intuition of distributional semantics used in word embeddings, Style2Vec learns the representation of a fashion item using other items in matching outfits as context. Two different convolutional neural networks are trained to maximize the probability of item co-occurrences. For evaluation, a fashion analogy test is conducted to show that the resulting representation connotes diverse fashion related semantics like shapes, colors, patterns and even latent styles. We also perform style classification using Style2Vec features and show that our method outperforms other baselines.
When Social Media Can Be Bad for You: Community Feedback Stifles Consumer Creativity and Reduces Satisfaction with Self-Designed Products

Enabling consumers to self-design unique products that match their idiosyncratic preferences is the key value driver of modern mass customization systems. These systems are increasingly becoming “social,” allowing for consumer-to-consumer interactions such as commenting on each other's self-designed products. The present research examines how receiving others' feedback on initial product configurations affects consumers' ultimate product designs and their satisfaction with these self-designed products. Evidence from a field study in a European car manufacturer's brand community and from two follow-up experiments reveals that receiving feedback from other community members on initial self-designs leads to less unique final self-designs, lower satisfaction with self-designed products, lower product usage frequency, and lower monetary product valuations. We provide evidence that the negative influence of feedback on consumers' satisfaction with self-designed products is mediated by an increase in decision un.