Miracle-dz/UniFAR-FTUs huggingface dataset:
Parametrical Regulation of Economic Growth Based on the Lucas Endogenous Model with Human Capital

This paper presents the results of application of the parametrical regulation theory for economic growth of Kazakhstan national economy on the basis of the Lucas endogenous model with a personalized human capital. The parameters of the considered model are estimated using the statistical data of evolution of the Kazakhstan national economy. The parametric sensitivity of the model solution is surveyed. The dependence of optimal values of the criterion on unregulated economic parameters is prospected.
Display Field Communication: Fundamental Design and Performance Analysis

The prevalence of cameras in consumer electric devices has led not only to many visual-sensing applications, but also potential use of cameras for communication purposes. With the increasing interest in optical camera communication technology and quick response codes, the display-to-camera (D2C) link has become a valuable side channel in ubiquitous computing environments. This paper proposes a new concept of display field communication (DFC), where the image on the electronic display is a transmitter and the camera is a receiver, meaning that data can be transmitted via the D2C links and image sequences can be displayed for their original purpose without serious visible artifacts. Because the proposed scheme embeds data at a designated spectral band, the hidden data do not reveal itself through normal displays and can only be revealed via the proposed decoding process. To observe the practical performance of the proposed DFC, the geometric distortion based on the various vision transformation parameters was considered and its effects on the communication performance according to the spectral bands were addressed. The simulation results showed that the maximum achievable data rate of approximately 9.5 kbps could be achieved for all perspective parameter cases when a gray-scale image size of 256 × 256 was used for embedding data, consisting of eight individual information vectors with their elements of 16-QAM modulated data. The proposed DFC algorithm showed satisfactory performance, providing a high data rate in the D2C communication link while the data embedded on the images was unobtrusive to the human eye.
Robust split‐plot designs

In many experimental situations, practitioners are confronted with costly, time consuming, or hard‐to‐change (HTC) factors. These practical or economic restrictions on randomization can be accommodated with a split‐plot design structure that minimizes the manipulation of the HTC factors. Selecting a good design is a challenging task and requires knowledge of the opportunities and restrictions imposed by the experimental apparatus and an evaluation of statistical performance among competing designs. Building on the well‐established evaluation criteria for the completely randomized context, we emphasize the unique qualitative and quantitative evaluation criteria for split‐plot designs. An example from hypersonic propulsion research is used to demonstrate the consideration of multiple design evaluation criteria. Published in 2007 by John Wiley & Sons, Ltd.
Analizando la influencia de la educación universitaria en el perfil emprendedor de los estudiantes

El trabajo tiene el objetivo de evaluar el efecto de la educacion universitaria (con y sin educacion emprendedora en la curricula) en el perfil emprendedor de los estudiantes. Particularmente, se analiza como la percepcion de factibilidad, la percepcion de deseabilidad, el conocimiento emprendedor, el area de estudio de los estudiantes y el ano de cursado, influyen en la intencion emprendedora de los estudiantes.Para ello se lleva a cabo un relevamiento en estudiantes universitarios de primero y ultimo ano de dos universidades publicas de la region. De las respuestas obtenidas se observa que incorporar educacion emprendedora tiene una influencia positiva en la intencion de emprender, generando un efecto contrario en los casos donde no se incluye. Ademas, los estudiantes que han recibido educacion emprendedora (en comparacion con los que no) reconocen haber afianzado sus conocimientos sobre el mundo emprendedor y haber desarrollado habilidades que podrian serles utiles en caso de decidirse a emprender.
DESIGN, OPTIMISATION AND EVALUATION OF PIROXICAM FAST DISSOLVING TABLETS EMPLOYING STARCH TARTRATE-A NEW SUPERDISINTEGRANT

Objective: To enhance the solubility of poorly soluble drugs by evaluating starch tartrate as a superdisintegrant in the formulation of fast dissolving tablets by employing 23 factorial design. Methods: Starch tartrate was synthesized by gelatinization process. The physical and micromeritic properties were performed to evaluate the synthesized starch tartrate. The fast dissolving tablets of piroxicam were prepared by using starch tartrate as a superdisintegrant in different proportions by direct compression technique using 23 factorial design. The drug content, hardness, friability, disintegration time and other dissolution characteristics like percent dissolved in 5 min (PD5), dissolution efficiency in 5 min (DE5%) and first-order rate constant (K1) were used in the evaluation of prepared fast dissolving tablets. Results: The superdisintegrant starch tartrate prepared was found to be fine, free-flowing slightly crystalline powder. Starch tartrate exhibited good swelling in water. The study between piroxicam and starch tartrate was shown the absence of interaction by fourier transform infrared spectra (FTIR) and differential scanning calorimetry (DSC). The drug content (99.83±0.56 %), hardness (3.7–3.9 kg/sq. Cm), and friability (0.12-0.15%) have been effective with regard to all the formulated fast dissolving tablets employing starch tartrate. The disintegration time of all the formulated fast dissolving tablets (FDTs) was found to be in the range of 12±0. 01 to 4500±0.02s. The optimized formulation F6 has the least disintegration time i.e., 12±0. 01s. The In vitro wetting time of the formulated tablets was found to be in the range of 35±0.09 to 1624±0.02s. The In–Vitro wetting time was less (i.e., 90s) in optimized formulation F6. The water absorption ratio of the formulated tablets was found to be in the range of 60±0.12 to 65±0.15%. The cumulative drug dissolved in the optimized formulation F6 was found to be 99.32±0.09% in 10 min. Conclusion: The dissolution efficiency of piroxicam was enhanced when starch tartrate was found to be a superdisintegrant when combined with crospovidone and, hence it could be used in the formulation of fast dissolving tablets to provide immediate release of the contained drug within 10 min.
Identifying giftedness: Validation of an Italian language giftedness checklist for teachers and parents

The purpose of this two-phase study was to validate the giftedness checklist of Sommer, Fink, and Neubauer (2008) in the Italian context, in both the version for teachers and for parents. The first phase was conducted with a sample of 570 children, 392 parents, and 136 teachers, with the aim of exploring the instrument factor structure, and analysing its psychometric properties. In the second phase, ratings provided by teachers and parents on the instrument were examined to investigate whether the instrument successfully discriminates between gifted and non-gifted students. Results indicate the usefulness of the instrument in the identification of giftedness.
Alienation based fault detection and classification in transmission lines

This paper deals with the application of alienation coefficients for the detection and classification of various faults on transmission lines. A Global Positioning System is used to synchronize sampling of current signals at both the ends of the transmission line. The alienation coefficients are obtained by comparing successive half cycles of absolute values of current samples at each end. At each end, Fault Index is calculated by adding alienation coefficients of local end and remote end. This Fault Index is compared with threshold to detect and classify the faults. The proposed algorithm has been tested successfully for various types of faults at different locations and different fault incidence angles. This scheme proved to be successful in discriminating non-fault transients from fault transients, also.
Preclinical development of AMG 139, a human antibody specifically targeting IL‐23

AMG 139 is a human anti‐IL‐23 antibody currently in a phase II trial for treating Crohn's disease. To support its clinical development in humans, in vitro assays and in vivo studies were conducted in cynomolgus monkeys to determine the pharmacology, preclinical characteristics and safety of this monoclonal antibody.
"PLS Turn UR Mobile on": Short Message Servie (SMS) Supporting Interactivity in the Classroom

The use of SMS messages for administrative support to distance students greatly enhances the quality thereof. The question is to what extent can SMS messages have a positive impact on the academic performance of students in a distance education environment in a developing context? It is obvious that SMS messages cannot be used for in-depth academic discourse, but that does not exclude their use for academic purposes. The Unit for Distance Education at the University of Pretoria developed five innovative academic SMS tools that mimic certain academic activities in a classroom. These included instructional, quiz and minilecture SMS messages. The messages were carefully constructed and were sent to an experimental group, while the control group received no SMS messages. The academic performance of the control and experimental groups was compared. The results show that the experimental group performed better than the control group in some of the aspects that were measured. Although it was not possible to conclusively prove that the SMS messages had a specific impact on academic performance, enough evidence exists to show that they at least played some role in the better performance of the experimental group.
Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(β‐amino esters)

Small interfering (si)RNA mediated inhibition of oncogenes or viral genes may offer great opportunities for the treatment of several diseases such as hepatocellular carcinoma and viral hepatitis. However, the development of siRNAs as therapeutic agents strongly depends on the availability of safe and effective intracellular delivery systems. Poly(β‐amino esters) (PbAEs) are, in contrast to many other cationic polymers evaluated in siRNA delivery, biodegradable into smaller, nontoxic molecules.
Design of a six-port junction based on single layer technology for UWB applications

In this paper, a novel ultra-wideband six-port junction based on microstrip single-layer technique is presented and discussed. The proposed design circuit uses a single layer elliptic coupler which offer a wide bandwidth compared to the hybrid one. The coupler and six-port circuit were designed and simulated using ADS software of Agilent. Simulation results show a good performance, especially in terms of bandwidth (from 3 to 6 GHz). This novel architecture is useful for low cost ultra-wideband application.
The antiandrogen cyproterone acetate induces synthesis of transforming growth factor β1 in the parenchymal cells of the liver accompanied by an enhanced sensitivity to undergo apoptosis and necrosis without inflammation

Recently, cases of liver damage and liver tumors have been reported after treatment of prostate cancer patients with the antiandrogen cyproterone acetate (CPA). In rat liver, CPA initiates a wave of DNA synthesis that is accompanied by apoptosis. In apoptotic hepatocytes, a latent form of transforming growth factor β1 (TGF‐β1) is detectable by immunohistochemistry. Injection of a single dose of TGF‐ β1 induces apoptosis in the liver of animals pretreated with CPA but has an insignificant effect in untreated animals. In this study, we show by Northern analysis that there is increased expression of TGF‐β1 in the liver after CPA treatment. Detection of TGF‐β1 with in situ hybridization showed that TGF‐β1 was synthesized in the parenchymal cells. Time course and dose‐response experiments performed 48 hours after the last application of CPA showed that apoptotic nuclei with chromatin condensed at the nuclear periphery (AN) were already visible 2 hours after injection (0.13%), and apoptotic bodies (ABs) increased 2 to 9 hours after the injection (from 1.28% to 6.67%) after 25 μg TGF‐β1/kg. At 4.5 hours after injection, an induction of apoptosis could be detected with 0.25 microgram TGF‐β1/kg and after the maximum dose (250 μg TGF‐β1/kg) ANs (0.24%) and ABs (16.74%) were homogeneously distributed throughout the liver lobe. Irrespective of the dose or time after injection of TGF‐β1, 82% of the ABs were localized within hepatocytes. Liver enzymes were detected in high amounts in the serum (eightfold elevation of glutamate dehydrogenase, fivefold elevation of alanine transaminase [ALT]) 7 hours after the first visible sign of apoptosis. After an additional 20 hours, the liver contained many necrotic figures. These results suggest that the combination of TGF‐β1 expression coupled with a strikingly enhanced sensitivity to the induction of apoptosis could be responsible both for the liver damage and the development of liver tumors observed after treatment with CPA.
Potential role for retinoic acid in patients with Cushing's disease.

CONTEXT Cushing's disease, i.e. cortisol excess due to an ACTH-secreting pituitary adenoma, is a rare disorder with considerable morbidity and mortality but no satisfactory medical treatment as yet. Experimental data have recently shown that retinoic acid restrains ACTH secretion by tumoral corticotropes. OBJECTIVE Our objective was to evaluate the efficacy and safety profile of retinoic acid treatment in patients with Cushing's disease. DESIGN This is a prospective, multicenter study. Seven patients with Cushing's disease (three men, four postmenopausal women) were started on 10 mg retinoic acid daily and dosage increased up to 80 mg daily for 6-12 months. ACTH, urinary free cortisol (UFC), and serum cortisol as well as clinical features of hypercortisolism and possible side effects of retinoic acid were evaluated at baseline, during retinoic acid administration, and after drug withdrawal. RESULTS A marked decrease in UFC levels was observed in five patients; mean UFC levels on retinoic acid were 22-73% of baseline values and normalization in UFC was achieved in three patients. Plasma ACTH decreased in the first month of treatment and then returned to pretreatment levels in responsive patients whereas no clear-cut pattern could be detected for serum cortisol. Blood pressure, glycemia, and signs of hypercortisolism, e.g. body weight and facial plethora, were ameliorated to a variable extent on treatment. Patients reported only mild adverse effects, e.g. xerophthalmia and arthralgias. CONCLUSIONS Long-term treatment with retinoic acid proved beneficial and well tolerated in five of seven patients with Cushing's disease. This represents a novel, promising approach to medical treatment in Cushing's disease.
Brassicaceae INDEHISCENT genes specify valve margin cell fate and repress replum formation.

Members of the Brassicaceae family, including Arabidopsis thaliana and oilseed rape (Brassica napus), produce dry fruits that open upon maturity along a specialised tissue called the valve margin. Proper development of the valve margin in Arabidopsis is dependent on the INDEHISCENT (IND) gene, the role of which in genetic and hormonal regulation has been thoroughly characterised. Here we perform phylogenetic comparison of IND genes in Arabidopsis and Brassica to identify conserved regulatory sequences that are responsible for specific expression at the valve margin. In addition we have taken a comparative development approach to demonstrate that the BraA.IND. a and BolC.IND. a genes from B. rapa and B. oleracea share identical function with Arabidopsis IND since ethyl methanesulphonate (EMS) mutant alleles and silenced transgenic lines have valve margin defects. Furthermore we show that the degree of these defects can be fine-tuned for crop improvement. Wild-type Arabidopsis produces an outer replum composed of about six cell files at the medial region of the fruits, whereas Brassica fruits lack this tissue. A strong loss-of-function braA.ind. a mutant gained outer replum tissue in addition to its defect in valve margin development. An enlargement of replum size was also observed in the Arabidopsis ind mutant suggesting a general role of Brassicaceae IND genes in preventing valve margin cells from adopting replum identity.
The Impact of Internet Postings on Individual Investors

Many people share investment ideas online. This study investigates how investmentrelated Internet postings influence the behavior of those who read them. We use unique data from a social trading platform that allow us to observe the trading behavior of those who post comments – the traders – as well as the trading behavior of those who potentially act on comments – the followers. There is strong evidence that comments encourage followers to replicate investment decisions of traders. However, postings do not contain value-relevant information, suggesting that personal sentiment and biases drive followers’ reactions to the postings. Comments by traders who appear financially sophisticated are most influential, while followers that tend to be financially unsophisticated are most likely to trade on comments. JEL Classification: D14, G11, G23
Reflectance and resistivity of barely metallic LaTiO3.

The absolute reflectance of ${\mathrm{LaTiO}}_{3}$ was measured from 70 to 17 500 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$. The Kramers-Kronig-derived optical conductivity shows three sharp phonon structures near 170, 340, and 540 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$ that are explained by a factor-group analysis. The midinfrared spectrum is dominated by a broad absorption band with an onset near 600 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$. A comparison of reflectance and resistivity measurements indicates that the dc mobility is less than 3 ${\mathrm{cm}}^{2}$/V s at 300 K, and thus the carriers are somewhat localized.
Motor Nerve Preservation and Muscle Atrophy After Pectoralis Major Musculocutaneous Flap Surgery for Oromandibular Reconstruction

Objective:The authors investigated the clinical and histopathologic significance of medial pectoral nerve preservation/reinnervation of pectoralis major musculocutaneous flap for oromandibular reconstruction. Materials and Methods:The authors compared 13 patients treated with pectoralis major musculocutaneous flap reconstruction and 6 control patients treated by rectus abdominis musculocutaneous flap reconstruction without motor nerve restoration. Subjective awareness was scored to evaluate changes in the facial contour due to muscle atrophy, and objective evaluation was performed in few patients. In addition, the authors performed histopathologic analysis of both muscle atrophy and nerve regeneration in 20 patients from whom samples were available. Results:Subjective awareness of changes in the facial contour induced by muscle atrophy was low among patients with nerve preservation/reinnervation, but there were objective changes at 3 months after surgery among patients who underwent nerve resection. In the patients who had medial pectoral nerve preservation or nerve restoration by nerve suture, favorable facial symmetry was retained at 5 years after surgery. Even though the motor nerve was preserved or restored, fatty degeneration and fibrosis were noted in approximately 30% of the total surface area of the muscle, and type I fibers had decreased to 36% that of control at 7 years after surgery. However, regressive changes were inhibited for 1 year after surgery; in contrast, changes corresponding to those noted at 7 years after surgery were observed by 3 months in the patients with nerve resection. Conclusion:Thus, the authors showed that preservation or restoration of nerves can delay muscle and have highlighted the potential benefits of this approach.
Systematic Examination of the Updated Framingham Heart Study General Cardiovascular Risk Profile

Background— An updated Framingham risk prediction tool was recently published. It features an expanded end point of general cardiovascular disease and a “vascular age” risk communication analogy. Methods and Results— We systematically examined the tool to determine which risk factor combinations allow risk thresholds to be reached and how different risk factor burdens translate into vascular age. We varied risk factor levels in isolation and combination and observed risk output patterns, with high risk defined as ≥20% 10-year predicted risk. As expected, we found that age is the major determinant of 10-year predicted risk for both men and women. Younger individuals tend not to exceed 20% 10-year risk even with multiple risk factors, although with marked risk factor burden, including both smoking and diabetes mellitus, men as young as 35 years of age and women as young as 40 years of age can be classified as high risk. For the risk factor levels we entered, predicted risk ranges from 3.1% to 46.8% for a 45-year-old man and 2.4% to 42.7% for a 55-year-old woman. Likewise, vascular age ranges from 37 to >80 years for a 45-year-old man and 39 to >80 years for a 55-year-old woman. Conclusions— The inclusion of noncoronary end points in this tool expands the range of predicted risks for men and women at all ages studied. Nevertheless, many younger individuals with high risk factor burden have low 10-year predicted risk. Wide ranges of “vascular age” are available for most chronological ages to assist with risk communication.
PHASE MEASUREMENT OF LIGHT ABSORPTION AND SCATTER IN HUMAN TISSUE

Analog and digital technologies are presented for precise measurement of propagation delay of photons from source and detector placed on portions of the human body. The goal of the apparatus design is to quantify absorption (μa) and scattering (μs′) induced by biological pigments and biological structures, respectively. Body tissues are highly scattering with a mean distance between scatterers of less than a mm (at 700–850 nm). Significant absorption is mainly due to 5%–10% of the tissue volume occupied by blood. Measurement of μa and μs′ is done by both time and frequency domain equipment. This article focuses upon frequency domain equipment because of its simplicity, reduced noise bandwidth, versatility, and the strong analogy to very high frequency/ultrahigh frequency communication devices, particularly those using phase modulation. Comparisons are made of homodyne and heterodyne systems together with evaluation of single and multiple side band systems, with particular emphasis on methods for multiplex.
Author ' s personal copy Short communication EMAS statement : Benign accountability or wishful thinking ? Insights from the Greek EMAS registry

Do organizations certified under the Eco-Management and Audit Scheme (EMAS) effectively discharge their environmental accountability through their statements? Is the EMAS statement a step forward for the transparency of environmental management and the empowerment of organizational stakeholders’ decision-making? Drawing from the Greek EMAS registry we apply an evaluation method for the completeness and materiality of environmental statements. While the latest version of the EMAS Regulation has introduced a set of forward-looking e yet challenging e improvements, the application of the standard should be closely examined. With this in mind, the key objective of this research note is to provide e from a descriptive standpoint e insights on the content of EMAS-based environmental accountability and a basis for future research as well as fruitful policy debate. 2013 Elsevier Ltd. All rights reserved.