Miracle-dz/UniFAR-FTUs huggingface dataset:
IL-23–Mediated Psoriasis-Like Epidermal Hyperplasia Is Dependent on IL-17A

IL-23 and Th17 cells producing IL-17A and IL-22 are found in excess in skin affected by psoriasis. Previous studies showed that IL-22, but not IL-17A, mediates psoriasis-like epidermal hyperplasia following recombinant murine (rm)IL-23 injections into skin. To further investigate the role of IL-17A, ears of mice were injected with rmIL-23. Investigators blinded to treatment conditions and mouse genotypes measured ear swelling, epidermal thickness, and cytokine expression. In wild-type (WT) mice, rmIL-23 induced ear swelling (p < 0.001, all p values versus saline), epidermal hyperplasia by histology (p < 0.001) and confocal microscopy (p < 0.004), and expression of both IL-17A and IL-22. As expected, rmIL-23 injections into IL-22−/− mice resulted in relatively little ear swelling (p < 0.09) and epidermal hyperplasia (p < 0.51 by histology and p < 0.75 by confocal microscopy). Notably, rmIL-23 injections into IL-17A−/− mice produced little ear swelling (p < 0.001, versus IL-23–injected WT mice) and epidermal hyperplasia (p < 0.001 by histology and p < 0.005 by confocal microscopy), even though IL-22 was readily induced in these mice. Furthermore, systemic delivery of blocking Abs directed against either IL-22 or IL-17A completely inhibited IL-23–induced epidermal hyperplasia in WT mice. These results demonstrate that IL-17A, like IL-22, is a downstream mediator for IL-23–induced changes in murine skin and that both of these Th17 cytokines are necessary to produce IL-23–mediated skin pathology. IL-17A may represent an attractive therapeutic target in individuals with psoriasis by blocking downstream effects of IL-23.
Equivalence and Synthesis of Causal Models

Scientists often use directed acyclic graphs (dags) to model the qualitative struc­ ture of causal theories, allowing the parameters to be estimated from observational data. Two causal models are equivalent if there is no experiment which could dis­ tinguish one from the other. A canonical representation for causal models is pre­ sented which yields an efficient graphical criterion for deciding equivalence, and provides a theoretical basis for extracting causal structures from empirical data. This representation is then extended to the more general case of an embedded causal model, that is, a dag in which only a subset of the variables are observ­ able. The canonical representation presented here yields an efficient algorithm for determining when two embedded causal models reflect the same dependency information. This algorithm leads to a model theoretic definition of causation in terms of statistical dependencies.
Evaluation of changes in haptoglobin and C-reactive protein concentrations caused by freezing of saliva and meat juice samples collected from healthy and diseased pigs.

OBJECTIVE To evaluate changes in stability of haptoglobin and C-reactive protein (CRP) concentrations caused by freezing of saliva and meat juice samples. ANIMALS 16 specific-pathogen-free pigs and 16 pigs with clinical signs of disease. PROCEDURES Saliva and diaphragmatic muscle were collected immediately before and after slaughter, respectively. Haptoglobin and CRP concentrations of pooled samples were measured before storage (day 0) and after 7, 15, 30, 60, 120, 210, and 365 days of storage at -20°C and after repeated freezing-thawing cycles (up to 7 times). In a second experiment, addition of a protease-inhibitor cocktail to saliva and storage of saliva samples at -80°C for up to 30 days were assessed for effects on CRP concentrations. RESULTS Haptoglobin concentrations in saliva did not change for up to 120 days in samples stored at -20°C, but longer storage times and multiple freezing-thawing cycles increased haptoglobin concentrations. Salivary CRP concentrations decreased significantly after 7 days of storage at -20°C, and addition of a protease-inhibitor cocktail did not improve CRP stability. Lower temperatures limited salivary CRP degradation. In meat juice, haptoglobin and CRP concentrations were stable at -20°C up to 210 days. CONCLUSIONS AND CLINICAL RELEVANCE Acute-phase protein measurements in saliva should be performed as soon as possible after sample collection. When this is not possible, storage temperature of -80°C is recommended. Acute-phase protein concentrations appeared to be more stable in meat juice samples than in saliva samples. Saliva and meat juice could be used as alternatives to serum for haptoglobin and CRP analysis.
A Socio-Technical Analysis Of M-Commerce In Japan: Research In Progress

This paper describes ongoing research investigating mobile commerce (m-commerce) in Japan. Using a social informatics perspective to inform a sociotechnical analysis of the uses of mobile phones by a sample of Japanese consumers, this research provides insights into ways in which Japanese culture is changing as mobile phone technologies and m-commerce become routinized in Japanese life.
Advanced Battery Management and Diagnostic System for Smart Grid Infrastructure

This paper presents the design and implementation of an advanced battery management system (BMS). The basic concept is to divide each series battery array into sub-arrays where each battery is individually monitored and managed. The proposed BMS continuously monitors the voltage, current, and energy of each battery. Based on these measurements, the BMS can calculate individual state of charge (SoC) levels and C-rates. Furthermore, the system has the capability to isolate each individual battery to apply different charging profiles and advanced diagnostics to detect the correct problems. Pulsed charging is deployed using different duty cycles for SoC balancing. The isolated battery is bypassed to maintain uninterrupted supply to the load despite reduced series array voltage. An unidirectional dc-dc boost converter maintains a constant output voltage level to the load, regardless of the number of batteries connected, until the problem is corrected. A hardware implementation of the proposed BMS is explained in detail. The performance of the system is tested experimentally under different loading conditions, including heavy pulsed loads.
TIP47 Is Not a Component of Lipid Droplets*

TIP47 functions in the delivery of mannose 6-phosphate receptors from endosomes to the trans-Golgi network bothin vitro and in vivo. It binds directly and very specifically to the cytoplasmic domains of both the cation-independent and cation-dependent mannose 6-phosphate receptors. TIP47 is 43% identical to a lipid droplet-associated protein named adipophilin; much of the identity resides near the N termini of these proteins. It was recently reported in this journal, in a study using antiserum from this laboratory, that TIP47 is a constituent of lipid droplets (Wolins, N. E., Rubin, B., and Brasaemle, D. L. (2001) J. Biol. Chem. 276, 5101–5108). We show here that the findings of Wolins et al. were likely due to either a cross-reactive, unidentified protein in HeLa cells that is recognized by our antiserum and/or the fact that our serum also cross-reacts with the adipophilin protein itself, shown directly by expression of adipophilin inEscherichia coli. Using antibodies specific for residues 152–434 of TIP47, we show that TIP47 is not a constituent of lipid droplets.
Evaluation of a human body phantom for wearable antenna measurements at the 5.8GHz band

This paper examines the far-field patterns of a monopole antenna mounted on different phantoms operating at the 5.8 GHz band. A 40cm height oval cross-section human body phantom is a good approximation for this analysis. The cost of the human equivalent liquid and the weight of the phantom can be reduced by using a hollow version of the proposed human body phantom.
Incipient mantle plume evolution: Constraints from ancient landscapes buried beneath the North Sea

Geological observations that constrain the history of mantle convection are sparse despite its importance in determining vertical and horizontal plate motions, plate rheology, and magmatism. We use a suite of geological and geophysical observations from the northern North Sea to constrain evolution of the incipient Paleocene‐Eocene Icelandic plume. Well data and a three‐dimensional seismic survey are used to reconstruct a 58–55 Ma landscape now buried ∼1.5 km beneath the seabed in the Bressay region. Geochemical analyses of cuttings from wells that intersect the landscape indicate the presence of angiosperm debris. These observations, combined with presence of coarse clastic material, interpreted beach ridges, and a large dendritic drainage network, indicate that this landscape formed subaerially. Longitudinal profiles of paleo‐rivers were extracted and inverted for an uplift rate history, indicating three distinct phases of uplift and total cumulative uplift of ∼350 m. Dinoflagellate cysts in the surrounding marine stratigraphy indicate that this terrestrial landscape formed in <3 Ma and was rapidly drowned. This uplift history is similar to that of a slightly older buried landscape in the Faeroe‐Shetland basin ∼400 km to the west. These records of vertical motion are consistent with pulses of anomalously hot asthenosphere spreading out from the incipient Icelandic plume. Using simple isostatic calculations, we estimate that the maximum thermal anomaly beneath Bressay was 50–100°C. Our observations suggest that a thermal anomaly departed the Icelandic plume around 57.4 ± 2.2 Ma at the latest and travelled with a velocity >∼ 150 km/Ma.
LBS AUGMENTED REALITY ASSISTIVE SYSTEM FOR UTILITIES INFRASTRUCTURE MANAGEMENT THROUGH GALILEO AND EGNOS

Abstract. There is a continuous and increasing demand for solutions, both software and hardware-based, that are able to productively handle underground utilities geospatial data. Innovative approaches that are based on the use of the European GNSS, Galileo and EGNOS, sensor technologies and LBS, are able to monitor, document and manage utility infrastructures’ data with an intuitive 3D augmented visualisation and navigation/positioning technology. A software and hardware-based system called LARA, currently under develop- ment through a H2020 co-funded project, aims at meeting that demand. The concept of LARA is to integrate the different innovative components of existing technologies in order to design and develop an integrated navigation/positioning and information system which coordinates GNSS, AR, 3D GIS and geodatabases on a mobile platform for monitoring, documenting and managing utility infrastruc- tures on-site. The LARA system will guide utility field workers to locate the working area by helping them see beneath the ground, rendering the complexity of the 3D models of the underground grid such as water, gas and electricity. The capacity and benefits of LARA are scheduled to be tested in two case studies located in Greece and the United Kingdom with various underground utilities. The paper aspires to present the first results from this initiative. The project leading to this application has received funding from the European GNSS Agency under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 641460.
To Mitigate Insecure IoT Devices , Regulate Manufacturers or Consumers ?

Recent years have seen the emergence and proliferation of Internet-of-Things (IoT) devices. However, many of them are found to contain security vulnerabilities that adversaries could exploit remotely to launch high-profile attacks [1]. For example, the Mirai botnet compromised a few hundred thousand Internet-connected cameras, before it launched a distributed denial-of-service (DDoS) attack on a DNS provider used by Twitter and Reddit, causing widespread disruption on these major platforms [2]. As the total number of IoT devices is projected to reach a billion in the next five to ten years [3], attacks from insecure devices are likely to cause higher damages.
An accurate indoor localization approach using cellphone camera

Indoor localization has attracted more and more attention for its wide applications in location-based services. This paper proposes a new indoor localization mechanism using photos taken by cellphone camera. By scenario selection and image matching in an already built image database, we try to get the “closest” image and then utilize its reserved information to achieve the accurate indoor localization. We take advantage of convolutional neural networks (CNNs) and unsupervised learning for scenario selection which can effectively reduce the size of candidate image set, and then exploit ASIFT (Affine Scale Invariant Feature Transform) with epipolar geometry constraint for image matching within selected scenario. Our system can not only achieve sub-meter localization result but also obtain the orientation information of users, without any infrastructure but a mobile camera module. The proposed system is tested in a teaching building and achieved the promising results.
Suicide Attempts and Deaths in Sofala, Mozambique, From 2011 to 2014.

BACKGROUND Mozambique was recently estimated to have the highest suicide rate in Africa. AIMS To fill a knowledge gap on suicide attempts and deaths in Mozambique. METHOD We reviewed a census of 898 emergency psychiatric consultations from March 2013 to July 2014 and 1,173 violent death autopsy records from June 2011 to August 2014 at Beira Central Hospital in Sofala, Mozambique. RESULTS In all, 18.0% of emergency psychiatric consultations were suicide attempts. Females were disproportionately represented (68.3%, p < .001), and the mean age was 26.8 years. Rat poison was used in 66% of attempts, followed by unspecified methods (19.8%), and unspecified poisoning (6.8%). Of the violent death autopsies, 10% were suicides. Suicide deaths were more likely to be male (67.3%, p < .001), and the mean age was 30.8 years. Common methods were hanging (43.2%), unspecified substance (28.0%), or rat poison (26.3%). Common places of death were the hospital or hospital transit (46.4%) and the household (35.7%). Female suicide deaths more often involved toxic substances and males more often employed hanging. CONCLUSION Females more often present with suicide attempts, but deaths due to suicide are more frequent among males. Females more often use toxic substances, whereas males more often use lethal methods, such as hanging. Policies to reduce the availability or toxicity of rat poison should be considered.
Evidence of a topographic signal in surface soil moisture derived from ENVISAT ASAR wide swath data Evidence of a topographic signal in surface soil moisture derived from ENVISAT ASAR wide swath data.

The susceptibility of a catchment to ﬂooding is affected by its soil moisture prior to an extreme rainfall event. While soil moisture is routinely observed by satellite instruments, results from previous work on the assimilation of remotely sensed soil moisture into hydrologic models have been mixed. This may have been due in part to the low spatial resolution of the observations used. In this study, the remote sensing aspects of a project attempting to improve ﬂow predictions from a distributed hydrologic model by assimilating soil moisture measurements are described. Advanced Synthetic Aperture Radar (ASAR) Wide Swath data were used to measure soil moisture as, unlike low resolution microwave data, they have sufﬁcient resolution to allow soil moisture variations due to local topography to be detected, which may help to take into account the spatial heterogeneity of hydrological processes. Surface soil moisture content (SSMC) was measured over the catchments of the Severn and Avon rivers in the South West UK. To reduce the inﬂuence of vegetation, measurements were made only over homogeneous pixels of improved grassland determined from a land cover map. Radar backscatter was corrected for terrain variations and normalized to a common incidence angle. SSMC was calculated using change detection. To search for evidence of a topographic signal, the mean SSMC from improved grassland pixels on low slopes near rivers was compared to that on higher slopes. When the mean SSMC on low slopes was 30–90%, the higher slopes were slightly drier than the low slopes. The effect was reversed for lower SSMC values. It was also more pronounced during a drying event. These ﬁndings contribute to the scant information in the literature on the use of high resolution SAR soil moisture measurement to improve hydrologic models. © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Efficiency and Organizational Arrangements in the Utilization of Resources at Primary Health Care (PHC) in Machakos County, Kenya

Health care is costly and there is need for rational use of health care resources for the world to achieve universal health coverage (UHC). The preventive Primary Health Care (PHC) service is cheaper than the Secondary Health Care (SHC). PHC is strengthened through gatekeeper system, so the emphasis on the PHC for cost control is self-explanatory. This study aimed at determining the efficiency and organizational arrangements using human resources for health (HRH), laboratory services and supply of drugs as the performance indicators that determined rational use of resources in Machakos County, Kenya. This was a convergent parallel mixed methods cross-sectional study that employed qualitative and quantitative data collection techniques. The study targeted facility health managers in charges and policy implementers namely the Chief Officer of health, the Director of Prevention and PHC and the Medical Superintendents and patients seeking health care. A response rate of 83%was achieved (n=83), of whom 84.3% were nurses and 15.7% diploma medicine practitioners. Over (70%) of the health facilities had less than 3professional health workers. Exactly 75% of the community-based self-referrals cases would be treated at PHC level. Self referrals were largely due to patients’ perceived need for laboratory services (53.8%) and medicines (60%). On the contrary, 89.6% of the residents of Machakos County, Kenya were informed about PHC services, 91.7% were accessible to PHC and 93.7% had faith in health care providers at PHC level. The HRH, diagnostic equipment and essential drugs were not the main reasons for self-referrals, but perceived needs for drugs and laboratory services. The inverse and disproportionate attendances of patients at both PHC and SHC levels caused dissonance in service delivery and subsequent inefficiency in service delivery in Machakos County, Kenya. Proper supervision and implementation of referral policy available at county level should be emphasized.
Demand for Genetic Resources and the U.S. National Plant Germplasm System

Although genetic resources have strong public-goods characteristics, public genebanks often have struggled for adequate funding. A review of economic literature on the value of plant genetic resources indicated that more information is needed about germplasm use. The data compiled in this paper examine patterns of germplasm use for one of the world's largest national genebank networks, the U.S. National Plant Germplasm System (NPGS). Data on 10 major crops, gathered directly from within the NPGS and from end-users, revealed patterns of usage for germplasm during the period from 1995 to 1999. Data were collected describing the characteristics of NPGS users, the types of germplasm requested, the purpose of requests, and, when applicable, the specific traits sought. From these findings, we estimated the utility of distributed materials, their secondary use, and projected future demand for NPGS resources. To explore relationships between the usefulness of germplasm samples and accompanying data in a more systematic fashion, we estimated a linear regression. The regression model suggests that accompanying data make germplasm more useful. We conclude that demand for NPGS resources was substantial and came from broad range of users. Utilization rates were higher than suggested by past studies. Countries with developing economies made greater use of NPGS resources, relatively speaking, than did countries with high-income economies. Finally, demand for NPGS resources is likely to increase, especially among users in countries with developing economies.
The angiogenetic effect of intramuscular administration of VEGF on muscle. The influence of exercise on angiogenesis.

UNLABELLED Although angiogenetic therapy using recombinant growth factors holds much hope for the treatment of ischemic diseases, there are still unanswered questions including the method, doses or duration of therapeutic approach. We evaluated the angiogenetic effects of vascular endothelial growth factor (VEGF) on rat heart and gastrocnemius muscles when this was administered intramuscularly and compared them to those obtained from rats, which exercised daily. CONCLUSION Both daily swimming exercise and intramuscular administration of VEGF increased angiogenesis in rat heart, even though exercise alone was the only one that increased angiogenesis quite significantly. The combined protocol (administration of growth factor and exercise) led to an increase of angiogenesis in cardiac muscles. In contrast, there was no effect on the lateral gastrocnemius muscle either by VEGF or exercise, whereas these together induced angiogenesis locally at the site of injection.