Miracle-dz/UniFAR-FTUs huggingface dataset:
Partial vs full coverage for tandem lesions in culprit vessel during primary coronary intervention in patients with acute ST-elevation myocardial infarction--the PERFECT-AMI study.

BACKGROUND The efficacy of partial vs full coverage for tandem lesions in the culprit vessel during primary percutaneous coronary intervention (PCI) after ST-elevation myocardial infarction (STEMI) was compared in the present study. METHODS AND RESULTS The 76 patients with STEMI and tandem lesions in the culprit vessel were randomized to receive stent implantation for an occluded/culprit lesion only (partial group) or complete coverage of lesions (full group). After PCI, patients in the partial group had more complete ST-segment resolution (STR) at 90 min (60.5% vs 28.9%, P=0.006), Thrombosis In Myocardial Infarction (TIMI) flow grade 3 (68.4% vs 28.9%, P=0.001), and myocardial blush grade 3 (42.1% vs 15.8%, P=0.04) than those in the full group. At 6 months, the major adverse cardiac events-free survival rate did not differ significantly between groups, but left ventricular (LV) ejection fraction was improved in the partial group. Multivariate analysis revealed pre-procedural TIMI flow grade >1 and door-to-balloon time <90 min were positively associated with complete STR at 90 min, whereas full coverage for tandem lesions was an independent factor for poor STR (odds ratio 2.58, 95% confidence interval 1.08-5.42, P=0.03). CONCLUSIONS For acute STEMI patients with tandem lesions in the culprit vessel, primary stenting for the occluded lesion only is beneficial in improving myocardial perfusion and LV function.
Purification and Characterization of a Novel Erythrose Reductase from Candida magnoliae

ABSTRACT Erythritol biosynthesis is catalyzed by erythrose reductase, which converts erythrose to erythritol. Erythrose reductase, however, has never been characterized in terms of amino acid sequence and kinetics. In this study, NAD(P)H-dependent erythrose reductase was purified to homogeneity from Candida magnoliae KFCC 11023 by ion exchange, gel filtration, affinity chromatography, and preparative electrophoresis. The molecular weights of erythrose reductase determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and gel filtration chromatography were 38,800 and 79,000, respectively, suggesting that the enzyme is homodimeric. Partial amino acid sequence analysis indicates that the enzyme is closely related to other yeast aldose reductases. C. magnoliae erythrose reductase catalyzes the reduction of various aldehydes. Among aldoses, erythrose was the preferred substrate (Km = 7.9 mM; kcat/Km = 0.73 mM−1 s−1). This enzyme had a dual coenzyme specificity with greater catalytic efficiency with NADH (kcat/Km = 450 mM−1 s−1) than with NADPH (kcat/Km = 5.5 mM−1 s−1), unlike previously characterized aldose reductases, and is specific for transferring the 4-pro-R hydrogen of NADH, which is typical of members of the aldo/keto reductase superfamily. Initial velocity and product inhibition studies are consistent with the hypothesis that the reduction proceeds via a sequential ordered mechanism. The enzyme required sulfhydryl compounds for optimal activity and was strongly inhibited by Cu2+ and quercetin, a strong aldose reductase inhibitor, but was not inhibited by aldehyde reductase inhibitors and did not catalyze the reduction of the substrates for carbonyl reductase. These data indicate that the C. magnoliae erythrose reductase is an NAD(P)H-dependent homodimeric aldose reductase with an unusual dual coenzyme specificity.
Aplicando técnicas de inspeção de usabilidade para avaliar aplicações móveis

This paper presents a comparative study of three different methods for usability evaluation in Web mobile application: Heuristic Evaluation, Cognitive Walkthrough, and Web Design Perspectives-based Usability Evaluation (WDP). This research aims to evaluate which method presents the best performance on the usability evaluation of web applications for mobile devices. The study was conducted as a class activity for students of Human-Computer Interaction (HCI). The obtained results are very important to help the development of a specific technology that focus on the usability evaluation of mobile applications with the best cost/benefit ratio.
Self-similarity through high-variability: statistical analysis of ethernet LAN traffic at the source level

A number of recent empirical studies of traffic measurements from a variety of working packet networks have convincingly demonstrated that actual network traffic is self-similar or long-range dependent in nature (i.e., bursty over a wide range of time scales) - in sharp contrast to commonly made traffic modeling assumptions. In this paper, we provide a plausible physical explanation for the occurrence of self-similarity in high-speed network traffic. Our explanation is based on convergence results for processes that exhibit high variability (i.e., infinite variance) and is supported by detailed statistical analyses of real-time traffic measurements from Ethernet LAN's at the level of individual sources.Our key mathematical result states that the superposition of many ON/OFF sources (also known as packet trains) whose ON-periods and OFF-periods exhibit the Noah Effect (i.e., have high variability or infinite variance) produces aggregate network traffic that features the Joseph Effect (i.e., is self-similar or long-range dependent). There is, moreover, a simple relation between the parameters describing the intensities of the Noah Effect (high variability) and the Joseph Effect (self-similarity). An extensive statistical analysis of two sets of high time-resolution traffic measurements from two Ethernet LAN's (involving a few hundred active source-destination pairs) confirms that the data at the level of individual sources or source-destination pairs are consistent with the Noah Effect. We also discuss implications of this simple physical explanation for the presence of self-similar traffic patterns in modern high-speed network traffic for (i) parsimonious traffic modeling (ii) efficient synthetic generation of realistic traffic patterns, and (iii) relevant network performance and protocol analysis.
Validation of the HUMAC Balance System in Comparison with Conventional Force Plates

In recent years, there has been intensified development of cost-effective alternatives to conventional force plates, such as those of Kistler and AMTI, in clinical and scientific research. To our knowledge, the evidence for existing validity and reliability of the HUMAC Balance System has so far been lacking. Over the course of the study, the HUMAC Balance System, which is based on the WII Balance Board technology, was tested. 26 HUMAC Balance Systems in conjunction with 2 force plates, each from the manufacturers Kistler and AMTI, were examined and their properties under static and dynamic conditions were evaluated. Under static conditions, the HUMAC Balance System revealed a relatively constant and comparatively small margin of displacement error. However, tests of the force plates under dynamic conditions revealed contrasting results. The conventional force plates, with a margin of error of 2.5%, proved to have a smaller margin of error compared to the HUMAC Balance System, which had margins of error of 8.6% and 6.1% in x and y directions, respectively. A calibration method was developed to overcome these systematic deviations. After applying the calibration, the Balance Board margin of error was reduced to an acceptable maximum of 0.18%.
Simple method for the determination of rosiglitazone in human plasma using a commercially available internal standard.

To the best of our knowledge, bioanalytical methods to determine rosiglitazone in human plasma reported in literature use internal standards that are not commercially available. Our purpose was to develop a simple method for the determination of rosiglitazone in plasma employing a commercially available internal standard (IS). After the addition of celecoxib (IS), plasma (0.25 mL) samples were extracted into ethyl acetate. The residue after evaporation of the organic layer was dissolved in 750 microL of mobile phase and 50 microL was injected on to HPLC. The separation was achieved using a Hichrom KR 100, 250 x 4.6 mm C(18) with a mobile phase composition potassium dihydrogen phosphate buffer (0.01 m, pH 6.5):acetonitrile:methanol (40:50:10, v/v/v). The flow-rate of the mobile phase was set at 1 mL/min. The column eluate was monitored by fluorescence detector set at an excitation wavelength of 247 nm and emission wavelength of 367 nm. Linear relationships (r(2) > 0.99) were observed between the peak area ratio rosiglitazone to IS vs rosiglitazone concentrations across the concentration range 5-1000 ng/mL. The intra-run precision (%RSD) and accuracy (%Dev) in the measurement of rosiglitazone were <+/-10.69 and <-12.35%, respectively across the QC levels (50-1000 ng/mL). The extraction efficiency was >80% for both rosiglitazone and IS from human plasma. The lower limit of quantitation of the assay was 5 ng/mL. In summary, the methodology for rosiglitazone measurement in plasma was simple, sensitive and employed a commercially available IS.
Practical approach for recommender systems

Every day, number of pages gets added on web which makes tracking of their links cumbersome. Due to this, problem of overloaded data has come up. This issue led researchers to thoroughly go through different aspects of Web Usage Mining (WUM). Another issue of traditional system is of recommendations which are also a part of WUM and Web logs. This paper proposed a system of recommendations which uses tokenization to separate the users and information is conveyed to Resource Description Framework (RDF) for Semantic data generation and display. Session based clusters are formed and frequency of items is noted. Algorithms are also proposed for smooth working of the system. Web log information is needed for understanding the general mentality or behaviour of the user. We have also proposed Natural Language Processing (NLP) techniques for conditions where users preferences regarding products are not generated.
Balance As a Predictor of Ankle Injuries in High School Basketball Players

ObjectiveThe purpose of this study was to determine if a preseason measurement of balance while in a unilateral stance could predict susceptibility to ankle injury in a cohort of high school basketball players. Predicting risk for ankle injury could be important in helping to reduce the risk of these injuries and furthermore save health care costs. DesignCohort study. SettingData were collected at five high schools during the first 2 weeks of the 1997–1998 and 1998–1999 basketball seasons. Subjects210 (119 male, age = 16.1 ± 1.1 yr; height = 182.98 ± 7.4 cm; weight = 76.4 ± 10.9 kg; and 91 female, age = 16.3 ± 1.3 yr; height = 170.9 ± 7.8 cm; weight = 63.4 ± 8.4 kg) high school basketball players who did not sustain a time loss ankle or knee injury within the previous 12 months served as subjects. Subjects did not use prophylactic ankle taping or bracing during the season. Assessment of Risk FactorsBalance was quantified from postural sway scores measured while subjects performed unilateral balance tests with eyes both open and closed. Logistic regression analysis was carried out to determine if gender, dominant leg, and balance scores were related to ankle sprain injuries. In addition, Fischer's exact test was used to determine if the rate of ankle injuries was the same whether the subject had poor, average, or good balance. Balance was assessed by measuring postural sway with the NeuroCom New Balance Master version 6.0 (NeuroCom International, Clackamas, OR, U.S.A.). Testing to determine postural sway consisted of having subjects stand on one leg for three trials of 10 seconds with their eyes open, then repeated with their eyes closed. Subjects then underwent the same assessment while standing on the other leg. Postural sway was defined as the average degrees of sway per second (°S/S) for the 12 trials producing a compilation (COMP) score. Outcome MeasuresAnkle injury resulting in missed participation. ResultsSubjects who sustained ankle sprains had a preseason COMP score of 2.01 ± 0.32 (Mean ± SD), while athletes who did not sustain ankle injuries had a score of 1.74 ± 0.31. Higher postural sway scores corresponded to increased ankle sprain injury rates (p = 0.001). Subjects who demonstrated poor balance (high sway scores) had nearly seven times as many ankle sprains as subjects who had good balance (low sway scores) (p = 0.0002.) ConclusionIn this cohort of high school basketball players, preseason balance measurement (postural sway) served as a predictor of ankle sprain susceptibility.
High incidence of early postnatal transmission of human immunodeficiency virus type 1 in Bangui, Central African Republic.

HIV-1-infected mothers in sub-Saharan Africa commonly transmit HIV to their newborn infants through breast-feeding and when such children are breast-fed for longer than 6 months the risk of late postnatal HIV-1 transmission may be as high as 12%. Findings are reported on the risk of early postnatal HIV-1 transmission (EPT) found in a study involving the infants of HIV-1-infected women in Bangui Central African Republic. 43 children born to HIV-1-infected women who planned to breast-feed were enrolled at birth. 14 of the infants were infected perinatally including 2 neonates with positive polymerase chain reaction (PCR) results at birth. 8 infants were infected during the postnatal period with the first positive PCR results at age 6 months and 21 infants had consistently negative PCR results at 6 months. The estimated rate of EPT calculated by dividing the number of children with EPT by the number of children not contaminated in utero or perinatally was 27.6%. Almost 20% of the children born to HIV-1-infected women became infected through breast-feeding for less than 6 months. That the rate of EPT was almost twice that of previously reported late postnatal transmission suggests a marked infectivity of early breast milk. Strategies to reduce the risk of HIV infection through breast-feeding must take into account the timing of maternal HIV transmission.
Falsely high ankle-brachial index predicts major amputation in critical limb ischemia

Falsely high ankle-brachial index (ABI) values are associated with an adverse clinical outcome in diabetes mellitus. The aim of the present study was to verify whether such an association also exists in patients with chronic critical limb ischemia (CLI) with and without diabetes. A total of 229 patients (74 ± 11 years, 136 males, 244 limbs with CLI) were followed for 262 ± 136 days. Incompressibility of lower limb arteries (ABI > 1.3) was found in 45 patients, and was associated with diabetes mellitus (p = 0.01) and renal insufficiency (p = 0.035). Limbs with incompressible ankle arteries had a higher rate of major amputation (p = 0.002 by log-rank). This association was confirmed by multivariate Cox regression analysis (relative risk [RR] 2.67; 95% CI 1.27-5.64, p = 0.01). The relationship between ABI > 1.3 and amputation rate persisted after subjects with diabetes and renal insufficiency had been removed from the analysis (RR 3.85; 95% CI 1.25-11.79, p = 0.018). Dividing limbs with measurable ankle pressure according to tertiles of ABI, the group in the second tertile (0.323 ≤ ABI ≤ 0.469) had the lowest amputation rate (4/64, 6.2%), and a U-shaped association between the occurrence of major amputation and ABI was evident. No association was found between ABI and mortality. In conclusion, this study demonstrates that falsely high ABI is an independent predictor of major amputation in patients with CLI.
Crystal structure of dimethyl-1κ2 C-bis(μ-4-methylphenolato-1:2κ2 O:O)(N,N,N′,N′-tetramethylethylenediamine-2κ2 N,N′)indium(III)lithium(I)

The mixed bimetallic title compound, [InLi(CH3)2(C7H7O)2(C6H16N2)] or [(tmeda)Li-μ-(4-MeC6H4O)2InMe2] (tmeda is N,N,N′,N′-tetramethylethylenediamine), exhibits a four-membered LiO2In ring core via bridging 4-methylphenolate groups. The Li and In atoms are in distorted tetrahedral N2O2 and C2O2 bonding environments, respectively. The Li atom is further chelated by a tmeda group, yielding a spirocyclic structure.
The Third Republic from its Origins to the Great War, 1871-1914

A note on the translation Chronology Part I. The Origins of the Third Republic, 1871-1898 Jean-Marie Mayeur 1. The end of the notables, 1871-1879 2. Economy and society 3. The period of Jules Ferry, 1879-1885 4. Beliefs and cultures 5. The Republic confronted by nationalism and socialism 6. The moderate Republic, 1889-1898 Part II. A Radical Republic? 1898-1914 Madeleine Reberioux: 7. The Dreyfus affair 8. The France of the left-wing Bloc and the rise of Radicalism 9. Crisis and death of the Bloc, 1904-1907 10. The days of Imperialism 11. The avant-garde movements 12. France in 1914 Notes Bibliography Index.
Sudden Increase in Isolation of Group B Streptococci, Serotype V, Is Not Due to Emergence of a New Pulsed-Field Gel Electrophoresis Type

ABSTRACT Until recently, group B streptococcus, serotype V (GBS-V), was an infrequent cause of disease. It is now recognized as a significant cause of infections in both children and adults. To determine if this increase was due to the recent introduction and spread of a single clone of GBS-V, we analyzed, by pulsed-field gel electrophoresis (PFGE), the SmaI chromosomal DNA digests of 45 bacteria: 41 isolated from human infections between 1986 and 1996 in the United States, 2 from human infections in Argentina, and 2 from naturally infected mice. Seventeen patterns were found and arbitrarily designated patterns A to Q. Pattern N constituted 24 (53%) of the isolates and was found in all of the years tested and from all surveillance areas, as well as in both isolates from Argentina, and was very similar to the GBS-V isolated from a mouse. Pattern P was found in three isolates, pattern F was found in two, and the remaining patterns were found in one isolate each. We concluded that the majority of isolates of GBS-V are of one PFGE subtype and that this subtype was predominate before the increase in disease caused by GBS-V and that GBS-V disease is caused by several different subtypes.
Predictors of psychosis remission in psychotic disorders that co-occur with substance use.

OBJECTIVE To examine rates and predictors of psychosis remission at 1-year follow-up for emergency admissions diagnosed with primary psychotic disorders and substance-induced psychoses. METHOD A total of 319 patients with comorbid psychosis and substance use, representing 83% of the original referred sample, were rediagnosed at 1 year postintake employing a research diagnostic assessment. Remission of psychosis was defined as the absence of positive and negative symptoms for at least 6 months. Likelihood ratio chi-square tests and multivariate logistic regression were the main means of analysis. RESULTS Of those with a baseline diagnosis of primary psychotic disorder, 50% were in remission at 1 year postintake, while of those with a baseline diagnosis of substance-induced psychosis, 77% were in remission at this time point. Lower Positive and Negative Syndrome Scale (PANSS) symptom levels at baseline, better premorbid functioning, greater insight into psychosis, and a shorter duration of untreated psychosis predicted remission at 1 year in both diagnostic groups. No interaction effects of baseline predictors and diagnosis type were observed. A stepwise multivariate logistic regression holding baseline diagnosis constant revealed the duration of untreated psychosis (odds ratio [OR] = 0.97; 95% confidence interval [CI] = 0.95, 0.997), total PANSS score (OR = 0.98; 95% CI = 0.97, 0.987), Premorbid Adjustment Scale score (OR = 0.13; 95% CI = 0.02, 0.88), and Scale to Assess Unawareness of Mental Disorders unawareness score (OR = 0.84; 95% CI = 0.71, 0.993) as key predictors of psychosis remission. CONCLUSIONS The association of better premorbid adjustment, a shorter duration of untreated psychosis, better insight into psychotic symptoms, and lower severity of psychotic symptoms with improved clinical outcome, reported previously in studies of schizophrenia, generalizes to psychosis remission in psychotic disorders that are substance induced.
Efficient collision detection for point and polygon based models

This work deals with the problem of efficient collision detection for point-based and polygonbased models. We have investigated the following three main areas: 1. We propose a technique that allows for increasing the speed of collision detection by decreasing its quality. The main idea of our average-case approach is to estimate the probability of an intersection of two sets of polygons (or other primitives) in order to guide the simultaneous traversal of two bounding volume hierarchies. 2. We give a new definition of an implicit surface over a noisy point cloud based on the weighted least squares approach. We use a different kernel function that approximates geodesic distances by shortest paths in a geometric proximity graph. Thus, artifacts are reduced and the bandwidth and boundaries can automatically be determined. 3. We propose a point cloud hierarchy for collision detection between point clouds. This hierarchy approximates the surface at inner nodes and allows for excluding parts where no collision can occur. Moreover, our interpolation search can be used to find intersection points efficiently by utilizing the proximity graph. In all three areas, we have shown that algorithmic ideas of theoretical computer science lead to efficient, real time algorithms and allow for analyzing their quality and running time.
The Incidence and Risk Factors for Hypotension During Emergent Decompressive Craniotomy in Children with Traumatic Brain Injury

We conducted a retrospective cohort study in children <13 yr with traumatic brain injury (TBI) at a Level 1 pediatric trauma center to describe risk factors for intraoperative hypotension (IH) during emergent decompressive craniotomy. Between 1994 and 2004, 108 children underwent emergent decompressive craniotomy for TBI. Overall, 56 (52%) patients had IH. Independent risk factors for IH were each 10 mL estimated blood loss/kg (ARR 1.15 95% CI 1.08–1.22), each mm of computed tomography (CT) midline shift (ARR 1.04 95%CI 1.01–1.07), each 10 mL of CT lesion volume (ARR 1.03 95%CI 1.01–1.05), and emergency department (ED) hypotension (5/5 patients with ED hypotension had IH). CT midline shift ≥4 mm predicted IH (ARR 1.67 95% CI 1.06–2.63), independent of blood loss. IH occurred frequently during emergent decompressive craniotomy in children with TBI. ED hypotension, blood loss, CT lesion volume, and CT midline shift predicted IH. Anesthesiologists can expect children with preoperative CT midline shift ≥4 mm to have IH during this procedure.