Miracle-dz/UniFAR-FTUs huggingface dataset:
The Fourth Monitoring Report of the Early vs. Late Infantile Strabismus Surgery Study: The Early vs. Late Infantile Strabismus Surgery Study Group.

The Early vs. Late Infantile Strabismus Surgery Study Group is a group of strabismologists and orthoptists from 58 clinics in 11 European countries. They investigate whether early or late surgery is preferable in infantile strabismus, in a non-randomized, prospective, multi-center trial. (1) Infants between 6 and 18 months of age receive a standardized entry examination and are then operated either before their second anniversary in clinics A, or between their 32nd and 60th month of age in clinics B. The children are evaluated at age six. After completion of the study, the two groups can then be compared regarding degree of binocular vision, angle of strabismus and visual acuity of the worse eye relative to the better. The current status of the study is reported here. Up to December 13, 1996, 58 clinics have entered a total of 532 patients. Currently, 232 children have been entered in the early surgery group and 300 in the late surgery group. Completeness of data and forms are excellent. Thirty-eight patients have definitively dropped out. There is no evidence for inhomogeneities between the two therapy groups concerning the distribution of the four most important prognostic factors: spherical equivalents, horizontal angle of squint, degree of amblyopia and limitation of abduction.
A nucleic acid sequence-based amplification system for detection of Listeria monocytogenes hlyA sequences

A nucleic acid sequence-based amplification system primarily targeting mRNA from the Listeria monocytogenes hlyA gene was developed. This system enabled the detection of low numbers (< 10 CFU/g) of L. monocytogenes cells inoculated into a variety of dairy and egg products after 48 h of enrichment in modified listeria enrichment broth.
PENGARUH UKURAN PERUSAHAAN DAN FINANCIAL DISTRESS TERHADAP OPINI AUDIT GOING CONCERN(Studi Empiris pada Perusahaan Property, Real Estate dan Kontruksi Bangunan yang Terdaftar di BEI Tahun 2014-2016)

ABSTRAK Penelitian ini bertujuan untuk menganalisis ukuran perusahaan, financial distress terhadap opini audit going concern pada perusahaan property real estate dan konstruksi bangunan yang terdaftar di BEI periode 2014-2016. Dengan adanya kasus manipulasi data keuangan yang dilakukan oleh perusahaan besar seperti Enron, sehingga banyak pihak yang merasa dirugikan. Auditor harus mengemukakan secara eksplisit apakah perusahaan klien akan dapat mempertahankan kelangsungan hidupnya sampai setahun kemudian setelah pelaporan. Ada juga perusahaan yang dinyatakan pailit oleh BEI yang diakibatkan karena kondisi kesehatan keuangannya sakit atau kesulitan keuangan (financial distress) hal tersebut menyebabkan kelangsungan hidup perusahaan tersebut di pertannyakan (going concern). Data yang digunakan dalam penelitian ini adalah data sekunder yang diperoleh dari website resmi BEI berupa laporan keuangan tahunan dan laporan auditor perusahaan property real estate dan konstruksi bangunan yang terdaftar di BEI periode 2014-2016. Teknik pengambilan sample yang digunakan pada penelitian ini menggunakan teknik purposive sampling dengan kriteria tertentu dan diperoleh 51 perusahaan yang memenuhi kriteria sample. Metode penelitian yang digunakan adalah analisis regresi logistik dalam penelitian ini tidak memerlukan lagi asumsi normalitas dan heterokedastisitas dan autokorelasi tidak diperlukan untuk diuji. Hasil pengujian hipotesis menunjukan bahwa secara parsial ukuran perusahaan dan financial distress berpengaruh terhadap opini audit going concern dengan kontribusi pengaruh ukuran perusahaan memberikan pengaruh sebesar 3,3% terhadap opini audit going concern, dan konstribusi financial distress memberikan pengaruh sebesar 3,0% terhadap opini audit going concern. Sedangkan secara simultan ukuran perusahaan dan financial distress berpengaruh terhadap opini audit going concern dengan konstribusi pengaruh sebesar 9,1% terhadap opini audit going concern.
Rad54 is dispensable for the ALT pathway

Some immortal cells use the alternative lengthening of telomeres (ALT) pathway to maintain their telomeres instead of telomerase. Previous studies revealed that homologous recombination (HR) contributes to the ALT pathway. To further elucidate molecular mechanisms, we inactivated Rad54 involved in HR, in mouse ALT embryonic stem (ES) cells. Although Rad54‐deficient ALT ES cells showed radiosensitivity in line with expectation, cell growth and telomeres were maintained for more than 200 cell divisions. Furthermore, although MMC‐stimulated sister chromatid exchange (SCE) was suppressed in the Rad54‐deficient ALT ES cells, ALT‐associated telomere SCE was not affected. This is the first genetic evidence that mouse Rad54 is dispensable for the ALT pathway.
On the Donation of Constantine

Lorenzo Valla (1407-1457) was the most important theorist of the humanist movement. He wrote a major work on Latin style, "On Elegance in the Latin Language", which became a battle-standard in the struggle for the reform of Latin across Europe, and "Dialectical Disputations", a wide-ranging attack on scholastic logic. His most famous work is "On the Donation of Constantine", an oration in which Valla uses new philological methods to attack the authenticity of the most important document justifying the papacy's claims to temporal rule. It appears here in a new translation with introduction and notes by G. W. Bowersock, based on the critical text of Wolfram Setz (1976). This volume also includes a text and translation of the "Constitutum Constantini", commonly known as the "Donation of Constantine".
Unit commitment with load uncertainty by joint chance-constrained programming

This paper presents an algorithm to solve a unit commitment problem that takes into account the uncertainty in the demand. This uncertainty is included in the optimization problem as a joint chance constraint that bounds the minimum value of the probability to jointly meet the deterministic power balance constraints. The demand is modeled as a multivariate, normally distributed, random variable and the correlation among different time periods is also considered. A deterministic mixed-integer linear programming problem is sequentially solved until it converges to the solution of the chance-constrained optimization problem. Different approaches are presented to update the z-value used to transform the joint chance constraint into a set of deterministic constraints. Results from a realistic size case study are presented and the values obtained for the multivariate normal distribution probability are compared with the ones obtained by using a Monte Carlo simulation procedure.
Willingness to Pay for Energy Efficient Refrigerating Appliances in Accra, Ghana: A Choice Experiment Approach

Abstract The use of energy efficient refrigerating appliances in the domestic sector holds promise for savings on energy, CO2 emissions and CFC leakages, and more so for developing countries than for developed countries. However, the low saliency of energy efficiency and monetary savings impedes the uptake of energy efficient appliances by end-use consumers and suppliers of residential appliances. Moreover, there is the lack of information on how consumers value different refrigerating appliances and appliance features as well as how much they are willing to pay for same. Applying a choice experiment approach, this paper valued consumers’ preferences for energy efficient refrigerating appliances and found that willingness to pay (WTP) is significant and positive at GH¢3,078.12 ($690). However, evidence of the influence of socio-demographics on WTP and preferences is inconclusive.
Short Selling Pressure and Corporate Social Responsibility Performance: Evidence From a Natural Experiment

Using Regulation SHO as a natural experiment, we show that managers respond to a positive exogenous shock of short selling pressure by enhancing corporate social responsibility (CSR) performance. The positive effect of short selling on CSR is mainly driven by improvements in stakeholder CSR, rather than third-party CSR, and by improvements in CSR strengths rather than reductions in CSR concerns. We further find a significant increase in firms’ likelihood of issuing standalone CSR reports, suggesting that as a response to heightened short selling threat, managers actively convey the information relating to CSR activities to the market. Finally, our cross-sectional analyses show that the positive impact of short selling pressure on CSR performance and disclosure is more pronounced for firms in environments where stakeholders emphasize CSR and for firms with a high level of lendable shares. Overall, our evidence is consistent with our conjecture that managers use CSR strategically to deter short sellers by creating a positive image of the firm.
Customer engagement with brands in social media platforms

Purpose Social media brand platforms have become a popular means for engaged customers to share information and experiences with brands and other customers. However, empirical research on how customer engagement (CE) relates to customers’ sharing intentions with the brand is limited. This study aims to investigate causal patterns of four CE dimensions – focused attention, absorption, enthusiasm and interaction – together with two cognitive structure properties in stimulating sharing intentions with the brand. Design/methodology/approach Using data from 782 Chinese customers of brand pages on the social media platform Weibo, this paper is the first to use both finite mixture partial least squares (FIMIX-PLS) analysis and fuzzy-set qualitative comparative analysis (fsQCA) to empirically assess the impact of CE configurations on sharing intentions. Findings The findings imply that not all of the CE dimensions co-occur necessarily and that different configurations of them can produce superior sharing intentions, conditional on the cognitive structure of customers, including their level of brand knowledge and avant-gardism. Research limitations/implications Although restricted to customers on Weibo, the results inform practice about how social media technology can facilitate different CE configurations and customer sharing intentions. Practical implications The results inform brand managers’ segmentation efforts and CE content marketing initiatives that can induce different CE configurations and customer sharing intentions with customers that possess high avant-gard and brand knowledge characteristics. Originality/value This study is the first to substantiate how different CE configurations (as gestalts) affect sharing intentions in social media and to challenge conventional net-effects thinking about CE dimensions. Understanding how such conditional configurations foster sharing via a social media platform is advantageous because it can improve segmentation efforts to strengthen brand relationships.
Grapevine: A Wine Prediction Algorithm Using Multi-dimensional Clustering Methods

We present a method for a wine recommendation system that employs multidimensional clustering and unsupervised learning methods. Our algorithm first performs clustering on a large corpus of wine reviews. It then uses the resulting wine clusters as an approximation of the most common flavor palates, recommending a user a wine by optimizing over a price-quality ratio within clusters that they demonstrated a preference for.
Detection of fully refocused polyamine spins in prostate cancer at 7 T

1H MRSI is often used at 1.5 or 3 T to study prostate cancer, where the ratio of choline + creatine to citrate is taken as a marker for tumour presence. Recently, the level of polyamines (mainly spermine) has been shown to improve specificity even further. However, the in vivo detection of these polyamines (at 3.1 ppm) is hampered by signal cancellation as a result of J‐coupling effects and signal overlap with choline (3.2 ppm) and creatine (3.0 ppm) resonances. At higher magnetic field strengths, the chemical shift dispersion will increase, which allows the use of very selective radiofrequency pulses to refocus J‐coupled spins. In this work, we added selective refocusing pulses to a semi‐LASER (localisation based on adiabatic selective refocusing) sequence at 7 T, and optimised the inter‐pulse timings of the sequence for fully refocused detection of spermine spins, whilst maintaining optimised detection of choline, creatine and the strongly coupled spin system of citrate. Copyright © 2010 John Wiley & Sons, Ltd.
Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma.

PURPOSE Several histologic grading systems have been validated in soft tissue sarcomas (STS), but no system is currently accepted worldwide. The National Cancer Institute (NCI) and French Federation of Cancer Centers Sarcoma Group (FNCLCC) systems were examined comparatively in the same population of patients with STS to determine which system is the best prognosticator with regard to metastasis development and tumor mortality. PATIENTS AND METHODS Four hundred ten adult patients with nonmetastatic STS were examined. Histologic grade was established according to the NCI and FNCLCC systems in each case. The prognostic value of both systems was examined using univariate and multivariate (Cox's model) analyses, and special attention was devoted to tumors with discordant grades. RESULTS In univariate analysis, both the NCI and FNCLCC systems were of prognostic value to predict metastasis development and tumor mortality. In multivariate analysis, high-grade tumors, irrespective of the system used, size > or = 10 cm, and deep location were found to be independent prognostic factors for the advent of metastases. Tumor grade had a higher predictive value than size or depth, and higher prognostic weight was assigned to the FNCLCC grading system in Cox models. Grade discrepancies were observed in 34.6% of the cases. An increased number of grade 3 STS, a reduced number of grade 2 STS, and a better correlation with overall and metastasis-free survival within subpopulations with discordant grades were observed in favor of the FNCLCC system. CONCLUSION The FNCLCC system showed slightly increased ability to predict distant metastasis development and tumor mortality. The use of this system to evaluate STS aggressiveness might be favored.
An Overview on Feral Hog Management in Brazil after Three Years of Control Regulation

Author(s): da Rosa, Clarissa Alves; Wallau, Marcelo Osorio; Salerno, Rafael; Pedrosa, Felipe; de Souza, Agnis Cristiane; Puertas, Fernando; dos Reis, Tiago Xavier | Abstract: Feral hogs are known to be expanding their range in Brazil since late 1980s and reports of damage to crops and livestock predation have become more frequent lately. Just recently, the use of lethal methods for feral hog control was legalized in Brazil, and there are still several restrictions, particularly towards the purchase and transportation of guns and ammunition. Results of questionnaires from feral hog hunters showed that around half of them still act illegally, and hunting with dogs was the main technique used for controlling feral hogs. We believe that to enhance feral hog control in Brazil, legislation needs to be reviewed, and a national control program needs to be created involving researchers, government agencies, and hunters, working together on development and implementation of more efficient techniques for feral hog population control.
Doing e-Research with e-Library: Determinants of Perceived Ease of Use of e-Library

T. Ramayah has taught courses in Statistics, Operations Management, Research Methods, Forecasting and Computer Literacy at the undergraduate level. He has supervised numerous MBA students in the fields of Information Systems, Operations Management, Marketing Management and Organizational Behaviour. He is also currently supervising numerous students at the MA and PhD levels. He has also presented numerous papers at local and international conferences. He is also active in research publications having published research papers in several local and international journals of repute. He is currently Head of Department of Production/Operations Management, School of Management, Universiti Sains Malaysia.
Variation of codons 1961 and 2177 of the Stargardt disease gene is not associated with age-related macular degeneration.

OBJECTIVES To investigate the role of 2 specific alleles of the Stargardt disease gene (ABCA4) in the pathogenesis of age-related macular degeneration (AMD). Secondary objectives were to investigate differences in frequency of the G1961E allele in selected ethnic groups as well as to examine the segregation of both G1961E and D2177N alleles in 5 multiplex families with AMD. METHODS Five hundred forty-four patients with AMD and 689 controls were ascertained from 3 continents. Blood samples from 62 normal individuals of Somalian ancestry were also obtained. Participants were screened for the presence of these ABCA4 alleles with a combination of restriction digestion and single-strand conformation polymorphism analysis of polymerase chain reaction amplification products. Detected alleles were confirmed by DNA sequencing. The number of subjects exhibiting the G1961E or D2177N variants were compared between AMD and control groups using a 2-tailed Fisher exact test. RESULTS There was no significant difference (P >.1) in the frequency of the G1961E and D2177N alleles in patients with AMD (2.2%) vs controls (1.0%). In contrast, there was a significant difference (P< .001) in the frequency of the G1961E alleles between normal individuals of Somali ancestry (11.3%) and normal individuals from other populations (0.4%). There was no evidence of cosegregation of these alleles and the AMD phenotype in the 5 multiplex families with AMD examined. These two ABCA4 alleles were slightly more frequent in patients with AMD with choroidal neovascularization (2.7%) than those without this complication (2.5%). CONCLUSIONS Somali ancestry is more than 100 times more strongly associated with presence of the G1961E allele than the AMD phenotype. This study did not find any statistically significant evidence for involvement of the G1961E or D2177N alleles of the ABCA4 gene in AMD. CLINICAL RELEVANCE The ABCA4 gene is definitively involved in the pathogenesis of Stargardt disease and some cases of photoreceptor degeneration. However, it does not seem to be involved in a statistically significant fraction of AMD cases.
Pharmacokinetics of tulathromycin in edible tissues of healthy and experimentally infected pigs with Actinobacillus pleuropneumoniae

The aim of this study was the comparison of the tissue pharmacokinetics of tulathromycin in healthy pigs and pigs experimentally infected with Actinobacillus pleuropneumoniae (App). Tulathromycin was given to 24 healthy and 24 infected pigs by intramuscular injection at a single dosage of 2.5 mg kg−1 body weight (b.w.). Pigs were euthanised at each group and then samples of liver, kidney, muscle, injection site and skin with fat were taken at scheduled time points. Drug concentrations were determined by LC-MS/MS. In this study, higher values of the area under the concentration–time curves (AUC) were calculated in all tissue samples taken from infected than healthy pigs. In pigs with App the AUCs of liver, kidney, muscle, skin with fat and injection site were 1111, 1973, 235, 181 and 2931 mg kg−1 h, while in pigs without inflammation they were 509, 1295, 151, 111 and 1587 mg kg−1 h, respectively. Maximum drug tissue concentrations (Cmax) in infected animals were 2370, 6650, 2016, 666 and 83 870 µg kg−1, while in healthy pigs they were 1483, 6677, 1733, 509 and 55 006 µg kg−1, respectively. The eliminations half-times (T1/2) were respectively longer in all tissue samples taken from infected animals (from 157.3 to 187.3 h) than in healthy ones (from 138.6 to 161.2 h). The tulathromycin tissue concentrations were significantly higher (p < 0.05) in all tissue samples of the infected pigs compared with the healthy animals at 360 h (from 0.0014 to 0.0280) and at 792 h (from 0.0007 to 0.0242) after drug administration. The results suggest that the tissue pharmacokinetic properties and residue depletion of tulathromycin can be influenced by the disease state of animals.
USING CROWDSOURCING FOR PROJECT MANAGEMENT

Crowdsourcing is coined first by Jeff Howe and become more popular in recent years. It is concept of outsourcing in the crowd. Crowdsourcing can be useful to project managers when they need to perform tasks with low budget, massive participants, multi-disciplinary, expert or non-experts. Using 10 rules from Howe will help a project manager manage the crowd and achieve their project objective. By addressing some questions such as why should a project manager use crowdsourcing? What the benefits and risks of crowdsourcing. This articles explain the contribution of crowdsourcing in project and change management
A Hybrid Method for Calculating the Coupling to PCB Inside a Nested Shielding Enclosure Based on Electromagnetic Topology

Conventional analytical and numerical approaches are inefficient for the analysis of electromagnetic (EM) coupling effect on a printed circuit board (PCB) in complicated electric systems. This paper develops a hybrid method based on the combination of electromagnetic topology and analytical method or full-wave simulation. A coupling mechanism of PCB in a nested shielding enclosure is established, and the EM interactions from exterior fields to interior PCB are determined by the way of conductive and radiation coupling interference. The total load disturbance voltage of PCB trace is obtained by solving the BLT equation of the two interference paths. In this paper, the full-wave simulation method is adopted to calculate the electric field and numerical integration method is applied to solve the BLT equation. The results of the proposed method are in good agreement with the result of a commercial full-wave tool, which confirms its validity. Compared to numerical simulation, the proposed method simplifies the modeling process significantly and possesses better efficiency.
Essential roles of sphingosine 1‐phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation

The biological roles of sphingosine 1‐phosphate (S1P) and S1P receptors (S1PRs) have been broadly investigated. However, at present pathophysiological roles of S1P/S1PRs axis in liver fibrosis are not well defined. Here, we investigated the functions of S1P/S1PRs axis in human hepatic stellate cells (HSC) line, LX‐2 cells. We found that S1PR types 1, 2 and 3 (S1PR1–3) are clearly detected in LX‐2 cells, as determined by RT‐PCR, Western blot and immunocytochemistry analysis. S1P exerted a powerful migratory action on LX‐2 cells, as determined in Boyden chambers, and stimulated fibrogenic activity of LX‐2 cells, as demonstrated by increase of expression of smooth muscle α‐actin, procollagen α1(I) and α1(III) and total hydroxyproline content. Moreover, the effects of S1P were mimicked by S1PR1 agonist SEW2871, and abrogated by W146 (S1PR1 antagonist) and/or silencing S1PR1, three expression with small interfering RNA, suggesting the main roles of S1PR1 and 3. However, studies with S1PR2 antagonist JTE‐013 and silencing S1PR2 expression indicated that S1PR2 negatively regulated S1P‐induced cell migration. Interestingly, exogenously added S1P induced significant up‐regulation of sphingosine kinase‐1 and the synthesis of additional S1P, and expression of S1PR1,3, but not S1PR2. In conclusion, our data have identified an additional function regulated by S1P/S1PR1,3 axis involving migration and fibrogenic activation of HSCs. These results suggest that selective modulation of S1PR activity may represent a new antifibrotic strategy. J. Cell. Physiol. 226: 2370–2377, 2011. © 2010 Wiley‐Liss, Inc.