Miracle-dz/UniFAR-FTUs huggingface dataset:
0 Contact Hours Using the Bonny Method to Evoke Emotion & Access the Unconscious

The healing power of music has been recognized since ancient times. The use of music has been documented in diverse cultures worldwide, for ailments ranging from pain and cancer to depression and posttraumatic stress disorder. The various models of music therapy are based on different theoretical traditions, including behaviorist, humanist, and psychodynamic approaches. This article describes the music therapy approach known as the Bonny Method of Guided Imagery and Music (GIM) therapy, reviews its research base, and presents a first-person account of the experience of GIM treatment. The earliest records of the healing power of music indicate that medicine men or women augmented their curative or palliative powers with music, in the form of chanting, drumming, or the playing of flutes, gongs, or cymbals (Nutting & Dock, 1935). The use of music in healing is documented worldwide, for example, in Europe, Tibet, and the Americas (Hamel, 1979). Florence Nightingale (1859/1992) was the first nurse to write of music’s therapeutic potential. In modern America, music was used to treat depression, schizophrenia, and insomnia in World War II veterans (Chung, 1999), and posttraumatic stress disorder (PTSD) in Vietnam veterans (Blake, 1994). The National Association for Music Therapy, founded in 1950, and the American Association for Music Therapy, founded in 1971 (these two unified in 1998), heralded the acceptance of music therapy as a formal professional field (Lui, 1994). Multiple models of music therapy exist and are based on different theoretical traditions, including behaviorist, humanist, and psychodynamic approaches. This article will describe the music therapy approach known as the Bonny Method of Guided Imagery and Music (GIM) therapy and present a first-person account of the experience of one of the authors (T.H.W.), who was treated with GIM. the bonny method of Guided imAGery And music therApy Music therapist Helen Bonny developed GIM in 1970 at the Maryland Psychiatric Research Center (Bonny & Savary, 1973). Building on the theoretical foundations of Freud and Jung, as well as imagery techniques, Bonny posited the use of music to induce altered states of consciousness (Goldberg, 1995). She viewed music as a tool to enhance access to the unconscious; reduce defenses; and facilitate insight, creativity, and problem solving (Bush, 1995). During a GIM session, the therapist guides the client in exploring images and feelings inspired by musical selections chosen by the therapist (Chou & Lin, 2006). protocol GIM is unique among music therapy approaches in its use of a specific guiding protocol. The four phases of this protocol take place consecutively in each session and include (McKinney, 2002): l Prelude or preliminary discussion.
SIMPLIFIED REPRESENTATION OF LARGE RANGE DATASET

In this paper, we consider two approaches of simplifying mediumand large-sized range datasets to a compact data point set, based on the Radial Basis Functions (RBF) approximation. The first algorithm uses a Pseudo-Inverse Approach for the case of given basis functions, and the second one uses an SVD-Based Approach for the case of unknown basis functions. The novelty of this paper consists in a novel partitionbased SVD algorithm for a symmetric square matrix, which can effectively reduce the dimension of a matrix in a given partition case. Furthermore, this algorithm is combined with a standard clustering algorithm to form our SVD-Based Approach, which can then seek an appropriate partition automatically for dataset simplification. Experimental results indicate that the presented Pseudo-Inverse Approach requires a uniform sampled control point set, and can obtain an optimal least square solution in the given control point set case. While in the unknown control point case, the presented SVD-Based Approach can seek an appropriate control point set automatically, and the resulting surface preserves more of the essential details and is prone to less distortions.
Computation and application of tissue-specific gene set weights

Abstract Motivation Gene set testing, or pathway analysis, has become a critical tool for the analysis of high-dimensional genomic data. Although the function and activity of many genes and higher-level processes is tissue-specific, gene set testing is typically performed in a tissue agnostic fashion, which impacts statistical power and the interpretation and replication of results. Results To address this challenge, we have developed a bioinformatics approach to compute tissue-specific weights for individual gene sets using information on tissue-specific gene activity from the Human Protein Atlas (HPA). We used this approach to create a public repository of tissue-specific gene set weights for 37 different human tissue types from the HPA and all collections in the Molecular Signatures Database. To demonstrate the validity and utility of these weights, we explored three different applications: the functional characterization of human tissues, multi-tissue analysis for systemic diseases and tissue-specific gene set testing. Availability and implementation All data used in the reported analyses is publicly available. An R implementation of the method and tissue-specific weights for MSigDB gene set collections can be downloaded at http://www.dartmouth. edu/∼hrfrost/TissueSpecificGeneSets.
Effect of statins on sirtuin 1 and endothelial nitric oxide synthase expression in young patients with a history of premature myocardial infarction.

OBJECTIVE The present study was an investigation of the effect of statins on the expression of circulating sirtuin 1 (SIRT1) and endothelial nitric oxide synthase (eNOS) proteins, and on the distribution of single nucleotide polymorphisms (SNPs) of the SIRT1 gene in patients with a history of premature myocardial infarction (PMI). METHODS A total of 108 patients who had suffered from a premature ST-elevation myocardial infarction (STEMI) under the age of 45 years were enrolled in this study. While 79 patients had been taking statins since the index event, 29 patients had discontinued statin treatment after hospital discharge due to noncompliance or insufficient information about the importance of continuous statin therapy in post-MI patients. The control group consisted of 91 healthy patients without a previous cardiovascular event. The levels of SIRT1 and eNOS protein; oxidative stress markers, like total antioxidant status (TAS), total oxidant status (TOS), and the oxidative stress index (OSI); as well as the distribution of the SNPs rs7069102 and rs2273773 were measured and analyzed. RESULTS A significant increase in the SIRT1 level (p<0.001) and a significant decrease in the eNOS level (p=0.001) was observed in all genotypes and alleles for both SNPs in patients who received statin therapy compared with the control group. Both SNPs were distributed in a similar frequency in the 2 MI groups, irrespective of statin treatment. CONCLUSION Statins induce SIRT1 protein, which might have a cardioprotective role after PMI. In addition, the eNOS protein level was low in all of the MI patients, suggesting that impairment of eNOS expression is disease-specific without a causal link to SIRT1.
Opioid Discussion in the Twittersphere

ABSTRACT Background: The rise in opioid use and overdose has increased the importance of improving data collection methods for the purpose of targeting resources to high-need populations and responding rapidly to emerging trends. Objective: To determine whether Twitter data could be used to identify geographic differences in opioid-related discussion and whether opioid topics were significantly correlated with opioid overdose death rate. Methods: We filtered approximately 10 billion tweets for keywords related to opioids between July 2009 and October 2015. The content of the messages was summarized into 50 topics generated using Latent Dirchlet Allocation, a machine learning analytic tool. The correlation between topic distribution and census region, census division, and opioid overdose death rate were quantified. Results: We evaluated a tweet cohort of 84,023 tweets from 72,211 unique users across the US. Unique opioid-related topics were significantly correlated with different Census Bureau divisions and with opioid overdose death rates at the state and county level. Drug-related crime, language of use, and online drug purchasing emerged as themes in various Census Bureau divisions. Drug-related crime, opioid-related news, and pop culture themes were significantly correlated with county-level opioid overdose death rates, and online drug purchasing was significantly correlated with state-level opioid overdoses. Conclusions: Regional differences in opioid-related topics reflect geographic variation in the content of Twitter discussion about opioids. Analysis of Twitter data also produced topics significantly correlated with opioid overdose death rates. Ongoing analysis of Twitter data could provide a means of identifying emerging trends related to opioids.
PEEK-biphasic bioceramic composites promote mandibular defect repair and upregulate BMP-2 expression in rabbits

The present study aimed to investigate whether bone morphogenetic protein-2 (BMP-2) was involved in the repair of mandibular defects using polyether-ether-ketone biphasic bioceramic (PEEK-BBC) composites in rabbits. PEEK-BBC composites with abundant and interconnected pores were prepared by calcination and characterized by scanning electron microscope. A mandibular defect model in rabbits was established using dental grinder to produce a square hole. A total of 60 rabbits were divided into four groups: Control, sham, surgery, and PEEK. In the PEEK group, the holes were filled with the PEEK-BBC composite stents. In the surgery group, the holes were produced but not filled with the composite stents. In the sham group, only the molar grooves were exposed and grinding was not performed. Animals without any treatment served as the control group. The success rate of model establishment was 100%. At 4, 8, and 16 weeks after the model was established, samples were collected from the molding sites. Bone repair was evaluated by H&E staining and Goldner trichrome staining. Bone structures in both control and sham groups were intact. A small number of osteocytes were observed in the surgery group. However, in the PEEK group, osteocytes were already evidently present in the composites at 4 weeks after surgery. At 8 and 16 weeks, there were large numbers of osteocytes in the pores of the composites. The mRNA and protein expression levels of BMP-2 were determined by reverse transcription-quantitative polymerase chain reaction and western blotting, respectively. The mRNA and protein expression levels of BMP-2 between the control and sham groups were similar and were continuously stable. However, following defect treatment, BMP-2 mRNA and protein expression was upregulated, which was enhanced by the PEEK-BBC composites. In conclusion, PEEK-BBC composites promoted the growth of osteocytes and repaired mandibular defects in rabbits, potentially via the upregulation of BMP-2 expression.
Hemoglobin Targets for Chronic Kidney Disease Patients with Anemia: A Systematic Review and Meta-analysis

Background Numerous studies have identified a relationship between hemoglobin (Hb) levels and mortality in patients with chronic kidney disease (CKD), which have raised concerns about the optimal Hb targets in correction of anemia. Our study is designed to investigate the potential effects of targeted Hb levels, aiming to give some evidence for therapy of renal anemia. Methodology/Principal Findings A comprehensive search of Medline, Embase and the Cochrane Database of Systematic Reviews was performed in December 2011 and updated in February 2012 for any new trials. Randomized trials designed to evaluate effects of high (generally the Hb about 13.0 g/dL) and low Hb (generally the Hb about 10.0 g/dL) targets on clinical outcomes in CKD patients with anemia were collected. All statistical analysis was calculated using the RevMan software available free from the Cochrane Collaboration. 24 trials involving 10361 patients were identified. Our findings demonstrated a statistically significant increased risk of mortality in the high Hb levels (RR 1.18; 95% CI 1.02 to 1.37) while the high and low Hb groups were both treated with ESAs. Overall, compared with low Hb levels, high Hb levels are associated with increased risk of hypertension (RR 1.40; 95% CI 1.11 to 1.75), stroke (RR 1.73; 95% CI 1.31 to 2.29), and hospitalizations (RR 1.07; 95% CI 1.01 to 1.14). However, there are no significant differences in the risk of non-fatal myocardial infarction (RR 1. 13; 95% CI 0.79 to 1.61) and renal replacement therapy (RR 1. 00; 95% CI 0.85 to 1.18). Conclusions/Significances Targeting low Hb levels are beneficial to CKD patients especially in the predialysis population. The optimal Hb targets to aim for in CKD patients and at what Hb level the risks of adverse events begin to increase remain elusive. Future studies are still needed to elucidate these questions.
Vitamin D status in psychotic disorder patients and healthy controls – The in fl uence of ethnic background

Vitamin D deficiency is common among patients with psychotic disorders and could be due to unknown disease mechanisms or contingent factors. However most studies are performed in chronic patients and have often failed to address the influence of ethnicity on vitamin D levels in clinical samples. We investigated serum concentrations of 25-hydroxy vitamin D (S-25 OH D) in first episode patients compared to patients with multi episodes and healthy controls; with a specific focus on differences between visible ethnic minorities and participants from the majority population. A total of 284 participants were included in this cross-sectional study. First episode patients with a DSM-IV psychotic disorder were matched on age, gender and ethnicity to participants from a multi episode patient sample (1:1) and healthy controls (1:2). We did not find any differences between either patient groups or the healthy controls, but participants from visible ethnic minorities had significantly lower S-25 OH D than participants from the majority population. This implies that S-25 OH D should be routinely measured in persons from visible ethnic minorities since low levels are associated with higher levels of depressive symptoms. & 2015 Published by Elsevier Ireland Ltd.
Effects of CD36 Genotype on Oral Perception of Oleic Acid Supplemented Safflower Oil Emulsions in Two Ethnic Groups: A Preliminary Study

Abstract Previous studies demonstrate humans can detect fatty acids via specialized sensors on the tongue, such as the CD36 receptor. Genetic variation at the common single nucleotide polymorphism rs1761667 of CD36 has been shown to differentially impact the perception of fatty acids, but comparative data among different ethnic groups are lacking. In a small cohort of Caucasian and East Asian young adults, we investigated if: (1) participants could detect oleic acid (C18:1) added to safflower oil emulsions at a constant ratio of 3% (w/v); (2) supplementation of oleic acid to safflower oil emulsions enhanced perception of fattiness and creaminess; and (3) variation at rs1761667 influenced oleic acid detection and fat taste perception. In a 3‐alternate forced choice test, 62% of participants detected 2.9 ± 0.7 mM oleic acid (or 0.08% w/v) in a 2.8% safflower oil emulsion. Supplementation of oleic acid did not enhance fattiness and creaminess perception for the cohort as a whole, though East Asians carrying the GG genotype perceived more overall fattiness and creaminess than their AA genotype counterparts (P < 0.001). No differences were observed for the Caucasians. These preliminary findings indicate that free oleic acid can be detected in an oil‐in‐water emulsion at concentrations found in commercial oils, but it does not increase fattiness or creaminess perception. Additionally, variation at rs1761667 may have ethnic‐specific effects on fat taste perception.
CESI: Canonicalizing Open Knowledge Bases using Embeddings and Side Information

Open Information Extraction (OpenIE) methods extract (noun phrase, relation phrase, noun phrase) triples from text, resulting in the construction of large Open Knowledge Bases (Open KBs). The noun phrases (NPs) and relation phrases in such Open KBs are not canonicalized, leading to the storage of redundant and ambiguous facts. Recent research has posed canonicalization of Open KBs as clustering over manually-defined feature spaces. Manual feature engineering is expensive and often sub-optimal. In order to overcome this challenge, we propose Canonicalization using Embeddings and Side Information (CESI) -- a novel approach which performs canonicalization over learned embeddings of Open KBs. CESI extends recent advances in KB embedding by incorporating relevant NP and relation phrase side information in a principled manner. Through extensive experiments on multiple real-world datasets, we demonstrate CESI's effectiveness.
PM2.5 Induced the Expression of Fibrogenic Mediators via HMGB1-RAGE Signaling in Human Airway Epithelial Cells

Background The aim of the present study was to test whether fine particulate matter (PM2.5) induces the expression of platelet-derived growth factor-AB (PDGF-AB), PDGF-BB, and transforming growth factor-β1 (TGF-β1) in human bronchial epithelial cells (HBECs) in vitro via high-mobility group box 1 (HMGB1) receptor for advanced glycation end products (RAGE) signaling. Methods Sprague-Dawley rats were exposed to motor vehicle exhaust (MVE) or clean air. HBECs were either transfected with a small interfering RNA (siRNA) targeting HMGB1 or incubated with anti-RAGE antibodies and subsequently stimulated with PM2.5. Results The expression of HMGB1 and RAGE was elevated in MVE-treated rats compared with untreated rats, and PM2.5 increased the secretion of HMGB1 and upregulated RAGE expression and the translocation of nuclear factor κB (NF-κB) into the nucleus of HBECs. This activation was accompanied by an increase in the expression of PDGF-AB, PDGF-BB, and TGF-β1. The HMGB1 siRNA prevented these effects. Anti-RAGE antibodies attenuated the activation of NF-κB and decreased the secretion of TGF-β1, PDGF-AB, and PDGF-BB from HBECs. Conclusion PM2.5 induces the expression of TGF-β1, PDGF-AB, and PDGF-BB in vitro via HMGB1-RAGE signaling, suggesting that this pathway may contribute to the airway remodeling observed in patients with COPD.
Uterine and eggshell modifications associated with the evolution of viviparity in South American water snakes (Helicops spp.)

The evolution of viviparity requires eggshell thinning to bring together the maternal uterus and extraembryonic membranes to form placentae for physiological exchanges. Eggshell thinning likely involves reduced activity of the uterine glands that secrete it. We tested these hypotheses by comparing the uterine and eggshell structure and histochemistry among oviparous and viviparous water snakes (Helicops) using phylogenetic methods. Eggshell thinning occurred convergently in all three origins of viviparity in Helicops and was accomplished by the loss of the mineral layer and thinning of the shell membrane. Uterine glands secrete the shell membrane in both oviparous and viviparous Helicops. These glands increase during vitellogenesis regardless of the reproductive mode, but they always reach smaller sizes in viviparous forms. As there is no phylogenetic signal in eggshell thickness and gland dimensions, we conclude that interspecific differences are related to reproductive mode and not phylogeny. Therefore, our results support the hypothesis that eggshell thinning is associated with the evolution of viviparity and that such thinning result from a reduction in gland size in viviparous taxa. Interestingly, the shell membrane thickness of viviparous females of the reproductively bimodal Helicops angulatus is intermediate between their oviparous and viviparous congeners. Thus, although eggshell thinning is required by the evolution of viviparity, a nearly complete loss of this structure is not. However, uterine gland dimensions are similar across viviparous Helicops. Fewer glands or their functional repurposing may explain the thinner shell membrane in viviparous species of Helicops in comparison to viviparous females of the bimodal H. angulatus.
Introduced bullfrog facilitates pathogen invasion in the western United States

Batrachochytrium dendrobatidis (Bd), a causal agent of the amphibian fungal skin disease chytridiomycosis, has been implicated in the decline and extinction of over 200 species worldwide since the 1970s. Despite almost two decades of research, the history of Bd and its global spread is not well understood. However, the spread of the Global Panzootic Lineage of Bd (Bd-GPL), the lineage associated with amphibian die-offs, has been linked with the American bullfrog (Rana [Aqurana] catesbeiana) and global trade. Interestingly, R. catesbeiana is native to the eastern U.S., where no Bd-related declines have been observed despite Bd’s presence since the late 1800s. In contrast Bd has been found to have emerged in California and Mexico in the 1960s and 1970s, after which epizootics (i.e., epidemics in wildlife) ensued. We hypothesize that Bd-GPL spread from the eastern U.S. with the introduction of R. catesbeiana into the western US, resulting in epizootics and declines of native host species. Using museum records, we investigated the historical relationship between R. catesbeiana and Bd invasion in the western US and found that R. catesbeiana arrived in the same year or prior to Bd in most western watersheds that had data for both species, suggesting that Bd-GPL may have originated in the eastern US and R. catesbeiana may have facilitated Bd invasion in the western US. To predict areas with greatest suitability for Bd, we created a suitability model by integrating habitat suitability and host availability. When we incorporated invasion history with high Bd suitability, we found that watersheds with non-native R. catesbeiana in the mountain ranges of the West Coast have the highest disease risk. These findings shed light on the invasion history and disease dynamics of Bd in North America. Targeted historical surveys using archived specimens in natural history collections and present-day field surveys along with more localized, community-level studies, monitoring, and surveillance are needed to further test this hypothesis and grow our understanding of the disease ecology and host-pathogen dynamics of Bd.