Miracle-dz/UniFAR-FTUs huggingface dataset:
Chronic Myelogenous Leukemia Patients Circulating NK Cells of Advanced Phase NK Cell Differentiation and Can Be Found in Transgene Causes Abnormal BCR/ABL The

NK cells from the blood of chronic myelogenous leukemia (CML) patients are progressively decreased in number as the disease progresses from chronic phase to blast crisis. We hypothesize that BCR/ABL may be directly responsible by interfering with NK cell differentiation. CD34 (cid:1) HLA-DR (cid:1) cells from CML patients were studied for their capacity to differentiate into NK cells. The NK cell cloning frequency was signiﬁcantly decreased from CML CD34 (cid:1) HLA-DR (cid:1) cells compared with cells from normal donors, yet CD34 (cid:1) HLA-DR (cid:1) cells gave rise to BCR/ABL (cid:1) NK cells in some patients. This ﬁnding prompted us to further investigate circulating NK cells from the blood of CML patients. CD56 (cid:1) CD3 (cid:2) NK cells were sorted from CML patients and examined by ﬂuorescence in situ hybridization (FISH). In contrast to chronic phase CML, signiﬁcant numbers of NK cells from advanced phase CML patients were BCR/ABL (cid:1) , whereas T cells were always BCR/ABL (cid:2) regardless of the disease stage. To test the effects of BCR/ABL as the sole genetic abnormality, BCR/ABL was transduced into umbilical cord blood CD34 (cid:1) cells, and NK development was studied. p210-enhanced green ﬂuorescence protein-transduced cells gave rise to signiﬁcantly decreased numbers of NK cells compared with enhanced green ﬂuorescence protein transduction alone. In addition, the extrinsic addition of BCR/ABL- transduced autologous CD34 (cid:1) cells suppressed the NK cell differentiation of normal umbilical cord blood CD34 (cid:1) CD38 (cid:2) cells.
Market Efficiency and Hedge Fund Trading Strategies

Stock and option markets can at times reflect differing information. We identify three reasons for the presence of these periods of ’disagreement’ between the cash and derivatives markets: 1) high volatility and noise trading; 2) high level of risk aversion; 3) speculation versus hedging trades. This paper investigates the role that hedge funds, a proxy for sophisticated investors, play in the price discovery process between stock and option markets and the disagreement/agreement periods. We observe that a disparity in information between the two markets is often associated with deleveraging in directional exposures and reversal strategies. Posterior to the event, active tactical asset allocation in small and value factor investing takes place. We investigate four specific macro events which resulted in significant rebalancing by hedge fund manegers: the Thai Baht depreciation, the Dot-com bubble, the credit crunch and the Nasdaq correction.
Compositional Constraint Is the Key Force in Shaping Codon Usage Bias in Hemagglutinin Gene in H1N1 Subtype of Influenza A Virus

It is vital to unravel the codon usage bias in order to gain insights into the evolutionary forces dictating the viral evolution process. Influenza A virus has attracted attention of many investigators over the years due to high mutation rate and being cross-specific shift operational in the viral genome. Several authors have reported that the codon usage bias is low in influenza A viruses, citing mutational pressure as the decisive force shaping up the codon usage in these viruses. In this study, complete coding sequences of hemagglutinin genes for H1N1 subtype of influenza A virus have been explored for the possible codon usage bias acting upon these genes. The results indicate overall low bias with peaking ENC values. The GC content is found to be substantially low as against AT content in the silent codon sites. Significant correlations were observed in between the compositional parameters versus AT3, implying the possible role of the latter in shaping codon usage profile in the viral hemagglutinin. The data showed conspicuously that the sequences were A redundant with most codons preferring nucleotide A over others in the third synonymous codon site. The results indicated the pivotal role of compositional pressure affecting codon usage in this virus.
Bacterial Diversity Analysis of Huanglongbing Pathogen-Infected Citrus using PhyloChips and 16S rDNA Clone Library Sequencing

The bacterial diversity associated with citrus leaf midribs was characterized from citrus groves that contained the Huanglongbing (HLB) pathogen, which has yet to be cultivated in 2 vitro . We employed a combination of high-density phylogenetic 16S rDNA microarray and 16S rDNA clone library sequencing to determine the microbial community composition of 4 symptomatic and asymptomatic citrus midribs. Our results revealed that citrus leaf midribs can 5 support a diversity of microbes. PhyloChip analysis indicated that 47 orders of bacteria from 15 6 phyla were present in the citrus leaf midribs while 20 orders from 8 phyla were observed with 7 the cloning and sequencing method. PhyloChip arrays indicated that nine taxa were significantly 8 more abundant in symptomatic midribs compared to asymptomatic midribs. Candidatus Liberibacter asiaticus (Las) was detected at a very low level in asymptomatic plants, but was 10 over 200 times more abundant in symptomatic plants. The PhyloChip analysis was further 11 verified by sequencing 16S rDNA clone libraries, which indicated the dominance of Las in 12 symptomatic leaves. These data implicate Las as the pathogen responsible for HLB disease.
APPLYING DATA MINING TO TELECOM CHURN MANAGEMENT

In Taiwan, the wireless telecommunication market was opened to the private enterprises since 1997. As the deregulation and great advance of new technologies, the competition in wireless telecommunication industry is getting severe. Accordingly, churn prediction and management have become of great concern to the mobile operators. Mobile operators wish to retain their subscribers and satisfy their needs. Hence, they need to predict the possible churners and then utilize the limited resources to retain those customers. In response to the difficulty of churner prediction, this study applies data mining techniques to build a model for churner prediction. The study is referring to develop similar approach to support telecom churn management. Through an analysis result from telecom provider, the results indicated that the proposed approach has pretty good prediction accuracy by using customer demography, billing information, call detail records, and service changed log to build churn prediction model.
Individual psychology as component of entrepreneurial Process:The Cognitive Perspective Contribution of the New VentureCreation among E-Commerce Entrepreneurs in Malaysia

: Studies on entrepreneurs as one of the main components contributing to entrepreneurship particularly for new venture creation processes, has been widely highlighted by previous researchers. An entrepreneur is the main actor in entrepreneurship based on how they think and make decisions. Most previous researchers studying the cognitive aspects of the entrepreneur have looked at the process of creating new ventures in general, but research focusing on creating e-commerce businesses has not been investigated much at all. The aim of this study is to identify how the role of cognitive characteristics of e-commerce entrepreneurs has contributed to the creation of new e-commerce businesses in Malaysia. This research uses a case studies approach in which data was collected by interviewing a total of twelve e-commerce entrepreneurs from May 2013 until December 2014. The findings of this study have found the contribution to the creation of new businesses by cognitive entrepreneurs in e-commerce in Malaysia is based on personal background (i.e. education, family) and experience in a previous work & business that facilitates their creation of new businesses. Therefore, the government's role in encouraging entrepreneurial activity in the country needs to emphasize elements of entrepreneurs’ cognitive ability in order to enhance the economic development of the country through the emergence of new business in e-commerce in the future
Future changes in precipitation and impacts on extreme streamflow over Amazonian sub-basins

Because of climate change, much attention is drawn to the Amazon River basin, whose hydrology has already been strongly affected by extreme events during the past 20 years. Hydrological annual extreme variations (i.e. low/high flows) associated with precipitation (and evapotranspiration) changes are investigated over the Amazon River sub-basins using the land surface model ORCHIDEE and a multimodel approach. Climate change scenarios from up to eight AR4 Global Climate Models based on three emission scenarios were used to build future hydrological projections in the region, for two periods of the 21st century. For the middle of the century under the SRESA1B scenario, no change is found in high flow on the main stem of the Amazon River (Óbidos station), but a systematic discharge decrease is simulated during the recession period, leading to a 10% low-flow decrease. Contrasting discharge variations are pointed out depending on the location in the basin. In the western upper part of the basin, which undergoes an annual persistent increase in precipitation, high flow shows a 7% relative increase for the middle of the 21st century and the signal is enhanced for the end of the century (12%). By contrast, simulated precipitation decreases during the dry seasons over the southern, eastern and northern parts of the basin lead to significant low-flow decrease at several stations, especially in the Xingu River, where it reaches −50%, associated with a 9% reduction in the runoff coefficient. A 18% high-flow decrease is also found in this river. In the north, the low-flow decrease becomes higher toward the east: a 55% significant decrease in the eastern Branco River is associated with a 13% reduction in the runoff coefficient. The estimation of the streamflow elasticity to precipitation indicates that southern sub-basins (except for the mountainous Beni River), that have low runoff coefficients, will become more responsive to precipitation change (with a 5 to near 35% increase in elasticity) than the western sub-basins, experiencing high runoff coefficient and no change in streamflow elasticity to precipitation. These projections raise important issues for populations living near the rivers whose activity is regulated by the present annual cycle of waters. The question of their adaptability has already arisen.
Wide-area measurement-based stabilizing control of power system considering signal transmission delay

Recent technological advances in the area of wide-area measurement systems (WAMS) has enabled the use of a combination of measured signals from remote locations for centralized control purpose. The transmitted signals can be used for multiple swing mode damping using a single controller. However, there is an unavoidable delay involved before these signals are received at the controller site. To ensure satisfactory performance, this delay needs to be taken into account in the control design stage. This paper focuses on damping control design taking into account a delayed arrival of feedback signals. A predictor-based H/sub /spl infin// control design strategy is discussed for such time-delayed systems. The concept is utilized to design a WAMS-based damping controller for a prototype power system using a static var compensator. The controller performance is evaluated for a range of operating conditions.
Banking Regulation, Institutional Quality, and Financial Crises

This paper examines how financial regulation and institutional quality affect the probability of a banking crisis using a panel of 132 countries over the period 1999-2011. We find that the probability of a financial crisis increases moving from low to medium levels of regulation and decreases from medium to high levels of regulation. This relationship is sensitive to the institutional quality and creates a liberalization trap for “happy mediums”: only countries endowed with good institutions can undertake a liberalization process. This effect is larger for European Union (and Eurozone) members than other countries. As heterogeneity in institutional quality generates also different preferences, international agreements on banking regulation are hard to achieve, especially in Europe. Our results are consistent with several robustness econometric exercises.
User Experience - From a Participant to an Activist

At a time of wireless networks and instant interaction it should be obvious that in most product and service development cases customers and users would have a creative role, but this is not yet happening. On the other hand, in some cases customers have an essential role in service design and even in production. In this paper we raise the question why some companies have strong interaction with their customers and why some companies don’t involve users in their processes. In the field of co-creation we also introduce a new concept called user activism. The aim of our research is to define possible ways of user activism and its role in a particular branch of business, namely, food and gastronomy. During our research we tried to understand what the potential of co-creation is and what consequences might be observed when consumers are not engaged. We found the food and gastronomy business fruitful for the examination of customer and user involvement in co-creation activities because of the close link of food and gastronomic services to everyday life. As a summary, we came up with two extremes where, at one end, co-creation and user involvement are in the heart of business, which leads to user activism. At the other end, the food product and service design are often still based on the company or owner idea and do not reflect consumers’ needs and creativity. In between these two extremes we also identified some crowdsourcing cases as well as more experimental and artistic types of service production.
Supply Constraints and Directors’ Reputational Incentives

We examine how constraints on directors’ availability to serve on boards influence their labor market outcomes. We find that directors who lose (or leave) a board are more likely to subsequently gain a new board seat, regardless of their performance on the departed board, suggesting that directors often face binding supply constraints. Using three arguably exogenous changes in directors’ supply constraints, we find that this pattern of board substitution is most pronounced among directors who face greater supply constraints. Consistent with these supply constraints muting directors’ reputational incentives, we find that directors who join a new board are more likely to substitute boards—i.e., simultaneously leave one of their current boards rather than add to their total board seats—when they face greater supply constraints. Collectively, our evidence suggests that for many directors, supply constraints limit their ability to join new boards and thus diminish their reputational incentives.
Medical use of dimethyl sulfoxide (DMSO).

DMSO is a clear odorless liquid, inexpensively produced as a by-product of the paper industry. It is widely available in the USA as a solvent but its medical use is currently restricted by the FDA to the palliative treatment of interstitial cystitis and to certain experimental applications. Cutaneous manifestations of scleroderma appear to resolve (albeit equivocally) following topical applications of high concentrations of DMSO. A limited number of small clinical trials indicate that intravenous DMSO may be of benefit in the treatment of amyloidosis, possibly by mobilizing amyloid deposits out of tissues into urine. Dermal application of DMSO seems to provide rapid, temporary, relief of pain in patients with arthritis and connective tissue injuries. However, claims for antiinflammatory effects or acceleration of healing are currently unwarranted. There is no evidence that DMSO can alter progression of degenerative joint disease, and, for this reason, DMSO may be considered for palliative treatment only and not to the exclusion of standard antiinflammatory agents. The safety of DMSO in combination with other drugs has not been established; neurotoxic interactions with sulindac have been reported. In experimental animals, intravenous DMSO is as effective as mannitol and dexamethasone in reversing cerebral edema and intracranial hypertension. An initial clinical trial in 11 patients tends to support this latter application. DMSO enhances diffusion of other chemicals through the skin, and, for this reason, mixtures of idoxuridine and DMSO are used for topical treatment of herpes zoster in the UK. Adverse reactions to DMSO are common, but are usually minor and related to the concentration of DMSO in the medication solution. Consequently, the most frequent side effects, such as skin rash and pruritus after dermal application, intravascular hemolysis after intravenous infusion and gastrointestinal discomfort after oral administration, can be avoided in large part by employing more dilute solutions. Most clinical trials of DMSO have not incorporated the components of experimental design necessary for objective, statistical evaluation of efficacy. Randomized comparisons between DMSO, placebo and known active treatments were rarely completed. Final approval of topical DMSO for treatment of rheumatic diseases in particular will require a multi-center, randomized comparison between high and low concentrations of DMSO and an orally-active, nonsteroidal antiinflammatory agent. (ABSTRACT TRUNCATED AT 400 WORDS)
Muscle endurance, muscle tension and personality traits in patients with muscle or joint pain--a pilot study.

OBJECTIVE To investigate the relationships between personality traits, depressive symptomatology and continuous muscle tension. METHODS These were investigated by means of a visual analog scale and the presence of continuous muscle tension during repeated isokinetic shoulder flexions in patients with muscle or joint pain and controls. RESULTS A significantly higher level of muscle tension between contractions was found in the patient groups in painful muscles. The patients with primary fibromyalgia and trapezius myalgia differed in degree of depressive symptomatology compared to controls. CONCLUSION Inhibition of aggression correlated significantly with the tension level between contractions during the isokinetic test indicating interaction between psychological and somatic factors.
Co-creation and consumer’s purchasing intentions, any value in B2B activities?

Given the increasing competitive nature of global markets, consumers are able to choose from an ever- increasing quality of products and services with constant declining prices. Hence, better understanding of B2B value co-creation activities that governs suppliers’ relationship with a direct impact on consumer is of great importance. The general purpose behind the study is that customers are willing to buy products only if consumers are in demand of the manufactured products, and therefore, the marketing efforts should target the ultimate consumer as opposed to the buyer. The purpose of this study is to investigate the impact of B2B value co-creation on consumers in South East Asia’s manufacturing industry. The research questions of this study are as following; what is the impact of B2B value co-creation on consumer satisfaction? What is the effect of value co-creation behavior on repurchase Intention? What is the effect of value co-creation behavior on willingness to pay premium? Available literature that deals with B2B co-creation in South-East Asia is primarily concerned with examining the concept of value co-creation behavior and its impact within organizational settings, with little consideration given to B2B value co-creation from consumer standpoint. Hence, an approach that attempts to assess B2B value co-creation impact on the ultimate consumer provides a new insights and a greater understanding of B2B value co-creation relationship within this important geographical part of the Asian market. Findings show that B2B value co-creation activities have a positive impact on consumer satisfaction in SE-Asian manufacturing sector. Findings also reveal that B2B value co-creation activities have a positive effect on ultimate consumer repurchase intentions. This suggests that B2B activities involving value co-creation have a positive effect on ultimate product consumer repurchase intention.
Integrated Advertising and Supply Chain Plans for an Innovative Product under Uncertainty

Demand for an innovative product typically follows a diffusion process. Prior advertising research on the innovative new product assumes an infinite capacity and a deterministic demand situation. However, capacity constraints are common for the new products. Also, the demand for the new product is extremely difficult to predict before its launch. Nonetheless, a firm that deals with the new product mostly has to take initial advertising and production planning decisions under an uncertain demand and capacity constrained situation. After observing the initial demand, the firm generally adjusts its marketing and production plans as per the demand realized. In this paper, we suggest the use of a two stage stochastic programming with recourse to analyze this situation. Our results show how the operational characteristics such as inventory holding and back order costs can significantly influence the advertising under different diffusion patterns.
International Harmonization of Approaches for Developing Nutrient-Based Dietary Standards: Reviewers

Introduction —J. C. King and C. Garza . S13 Nutrient intake values (NIVs): A recommended terminology and framework for the derivation of values —J. C. King, H. H. Vorster, and D. G. Tome . S16 Nutrient risk assessment: Setting upper levels and an opportunity for harmonization —P. J. Aggett . S27 Using criteria to establish nutrient intake values (NIVs) —A. A. Yates . S38 Methods for using nutrient intake values (NIVs) to assess or plan nutrient intakes —S. P. Murphy and H. H. Vorster . S51 Determining life-stage groups and extrapolating nutrient intake values (NIVs) —S. Atkinson and B. Koletzko . S61 The role of dietand host-related factors in nutrient bioavailability and thus in nutrient-based dietary requirement estimates —R. Gibson . S77 Human nutrition and genetic variation —P. Stover . S101 Application of nutrient intake values (NIVs) —H. H. Vorster, S. P. Murphy, L. H. Allen, and J. C. King . S116 Trade, development, and regulatory issues in food —S. Ramaswamy and B. Viswanathan . S123 Beyond recommendations: Implementing food-based dietary guidelines for healthier populations —S. Smitasiri and R. Uauy . S141 Reviewers . S152 International Dietary Harmonization Meeting participants . S153
53 / 12 Information Transmission through Influence Activities

This paper studies the information transmission aspect of influence activities within an organization where privately informed division managers strategically communicate divisional information to headquarters to influence its capital allocation decisions. Although costly, influence activities can play a role in transmitting valuable information to headquarters. We define influence activities to be informative if they improve headquarters's inference and detrimental if they hamper it. We find that influence activities are more likely to be informative in organizations that are less averse to risk taking, that rely more on higher-power incentives, and that encourage competition in the form of contest. We also find that competition over scarce resources increases the overall level of influence activities.