Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Study of the Amazonian Macabea Cattle History

Macabea cattle are the only Bos taurus breed that have adapted to the wet tropical conditions of the Amazon. This breed has integrated into the culture of the indigenous Shuar-Asuar nations probably since its origins, being one of the few European zoogenetic resources assimilated by the deep-jungle Amazon communities. Despite its potential for local endogenous sustainable development, this breed is currently endangered. The present study used molecular genetics tools to investigate the within- and between-breeds diversity, in order to characterize the breed population, define its associations with other breeds, and infer its origin and evolution. The within-breed genetic diversity showed high values, as indicated by all genetic parameters, such as the mean number of alleles (MNA = 7.25±2.03), the observed heterozygosity (Ho = 0.72±0.02) and the expected heterozygosity (He = 0.72±0.02). The between-breeds diversity analysis, which included factorial correspondence analysis, Reynolds genetic distance, neighbor-joining analysis, and genetic structure analysis, showed that the Macabea breed belongs to the group of the American Creoles, with a Southern-Spain origin. Our outcomes demonstrated that the Macabea breed has a high level of purity and null influences of exotic cosmopolitan breeds with European or Asiatic origin. This breed is an important zoogenetic resource of Ecuador, with relevant and unique attributes; therefore, there is an urgent need to develop conservation strategies for the Macabea breed.
Change of self-narratives in depression: core conflictual relationship theme and innovative moments

This dissertation explores the role of narrative changes in psychotherapy. Narratives guide the interpretation of experiences through a set of implicit assumptions and rules. From these, the set of rules that guide interpersonal interactions, termed relational schemas, are particularly significant. Relational schemas of persons with psychological disorders tend to be highly rigid. This implies that their interpretation of experience do not encompass the diversity of life events thus becoming maladaptive. The Core Conflictual Relationship Theme (CCRT) is a method developed to identify recurrent patterns of interpersonal interactions, describing relational schemas through three components: client’s wishes and needs (W), the responses of the others to these needs (RO), and the responses of the self (RS). The rigidity of relational schemas is measured through the pervasiveness (dominance of a specific W, a specific RO and a specific RS), dispersion (the spread of all rated W, all RO and all RS) and valence (proportion of positive RO and RS). Research with this method has shown that symptoms recovery is associated with a more flexible (i.e. less pervasive or more disperse) CCRT and more positive RO and RS. Structures like relational schemas constitute the macro-narrative level of analysis. On the other hand, the moment-to-moment experiences constitute the micro-narrative level. It is proposed that change in macro-narratives in psychotherapy occur through the elaboration of micro-narrative events. While the CCRT represents the macro-narrative level, Innovative Moments (IMs), referring to experiences outside the maladaptive rules and assumptions, represents the micro-narrative level. IMs may allow the reorganization of an alternative macro-narrative, fostering a more flexible and satisfactory way of interpreting experiences. IMs can be organized in two levels: low-level IMs and high-level IMs. Lowlevel IMs create distance from the problematic macro-narrative, while high-level IMs are centered on the expansion of an alternative macro-narrative. Research with the Innovative Moments Coding System (IMCS) showed that recovered clients presented more IMs than unchanged ones. Moreover, high-level IMs differentiate recovered from unchanged clients and predicted the decrease of symptoms. Despite the body of research on clients’ narratives in psychotherapy, the association between different narrative levels has rarely been studied. This dissertation addresses this gap, analyzing possible associations between the micro-narrative level, the macro-narrative level and the
Chondroitinase ABC promotes axonal regeneration of Clarke's neurons after spinal cord injury

We examined whether enzymatic digestion of chondroitin sulfate (CS) promoted the axonal regeneration of neurons in Clarke's nucleus (CN) into a peripheral nerve (PN) graft following injury of the spinal cord. After hemisection at T11, a segment of PN graft was implanted at the lesion site. Either vehicle, brain-derived neurotrophic factor (BDNF) or chondroitinase ABC was applied at the implantation site. The postoperative survival period was 4 weeks. Treatment with vehicle or BDNF did not promote the axonal regeneration of CN neurons into the PN graft. Application of 2.5 unit/ml chondroitinase ABC resulted in a significant increase (12.8%) in the number of regenerated CN neurons. Double labeling with Fluoro-Gold and NADPH-diaphorase histochemistry showed that the regenerated CN neurons did not express nitric oxide synthase (NOS). Our results suggest that CS is inhibitory to the regeneration of CN neurons following injury of the spinal cord.
Postprandial inflammation is not associated with endoplasmic reticulum stress in peripheral blood mononuclear cells from healthy lean men

The consumption of lipids and simple sugars induces an inflammatory response whose exact molecular trigger remains elusive. The aims of the present study were to investigate (1) whether inflammation induced by a single high-energy, high-fat meal (HFM) is associated with endoplasmic reticulum stress (ERS) in peripheral blood mononuclear cells (PBMC) and (2) whether these inflammatory and ERS responses could be prevented by the chemical chaperone ursodeoxycholic acid (UDCA). A total of ten healthy lean men were recruited to a randomised, blind, cross-over trial. Subjects were given two doses of placebo (lactose) or UDCA before the consumption of a HFM (6151 kJ; 47·4 % lipids). Blood was collected at baseline and 4 h after the HFM challenge. Cell populations and their activation were analysed using flow cytometry, and plasma levels of inflammatory cytokines were assessed by ELISA and Luminex technology. Gene expression levels of inflammatory and ERS markers were analysed in CD14+ and CD14− PBMC using quantitative RT-PCR. The HFM induced an increase in the mRNA expression levels of pro-inflammatory cytokines (IL-1β, 2·1-fold; IL-8, 2·4-fold; TNF-α, 1·4-fold; monocyte chemoattractant protein 1, 2·1-fold) and a decrease in the expression levels of miR181 (0·8-fold) in CD14+ monocytes. The HFM challenge did not up-regulate the expression of ERS markers (XBP1, HSPA5, EDEM1, DNAJC3 and ATF4) in either CD14+ or CD14− cell populations, except for ATF3 (2·3-fold). The administration of UDCA before the consumption of the HFM did not alter the HFM-induced change in the expression levels of ERS or inflammatory markers. In conclusion, HFM-induced inflammation detectable on the level of gene expression in PBMC was not associated with the concomitant increase in the expression levels of ERS markers and could not be prevented by UDCA.
Mobile Indoor Augmented Reality - Exploring Applications in Hospitality Environments

Augmented reality (AR) is been increasingly used in mobile devices. Most of the available applications are set to work outdoors, mainly due to the availability of a reliable positioning system. Nevertheless, indoor (smart) spaces offer a lot of opportunities of creating new service concepts. In particular, in this paper we explore the applicability of mobile AR to hospitality environments (hotels and similar establishments). From the state-of-the-art of technologies and applications, a portfolio of services has been identified and a prototype using off-the-shelf technologies has been designed. Our objective is to identify the next technological challenges to overcome in order to have suitable underlying infrastructures and innovative services which enhance the traveller’s experience.
Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator β-glucan in a two-case ex vivo non-small-cell lung cancer study

Cancer and stromal cell metabolism is important for understanding tumor development, which highly depends on the tumor microenvironment (TME). Cell or animal models cannot recapitulate the human TME. We have developed an ex vivo paired cancerous (CA) and noncancerous (NC) human lung tissue approach to explore cancer and stromal cell metabolism in the native human TME. This approach enabled full control of experimental parameters and acquisition of individual patient's target tissue response to therapeutic agents while eliminating interferences from genetic and physiological variations. In this two-case study of non-small-cell lung cancer, we performed stable isotope-resolved metabolomic (SIRM) experiments on paired CA and NC lung tissues treated with a macrophage activator β-glucan and 13C6-glucose, followed by ion chromatography–Fourier transform mass spectrometry (IC-FTMS) and nuclear magnetic resonance (NMR) analyses of 13C-labeling patterns of metabolites. We demonstrated that CA lung tissue slices were metabolically more active than their NC counterparts, which recapitulated the metabolic reprogramming in CA lung tissues observed in vivo. We showed β-glucan-enhanced glycolysis, Krebs cycle, pentose phosphate pathway, antioxidant production, and itaconate buildup in patient UK021 with chronic obstructive pulmonary disease (COPD) and an abundance of tumor-associated macrophages (TAMs) but not in UK049 with no COPD and much less macrophage infiltration. This metabolic response of UK021 tissues was accompanied by reduced mitotic index, increased necrosis, and enhaced inducible nitric oxide synthase (iNOS) expression. We surmise that the reprogrammed networks could reflect β-glucan M1 polarization of human macrophages. This case study presents a unique opportunity for investigating metabolic responses of human macrophages to immune modulators in their native microenvironment on an individual patient basis.
EFFECTIVE MULTI-CONNECTION VIDEO STREAMING OVER WIMAX

The idea of multi-connection congestion control was originally applied to aggregate flows passing from computer cluster to cluster communicating over the public Internet. This paper considers the extension of multi-connection streaming to wired/wireless networks and in doing so reviews theoretical results for multi-connection streaming, including virtual multi-connections within a single physical connection. Streaming a single video over multiple TCP-Friendly Rate Control connections is a promising way of separately coping with both wireless channel losses and traffic congestion, without the need for cross-layer intervention or retransmission delay at the data-link layer. At the same time, the wireless channel is properly utilized, as throughput improves with an increasing number of connections. Nevertheless, over IEEE 802.16e (mobile WiMAX) tuning is needed to select the number of connections and the Time Division Duplex (TDD) frame size. The paper assesses the impact on video quality of packet drops due both to channel loss over a WiMAX access link and router buffer overflow across an all-IP network, consisting of broadband wireless access and core network. The paper also considers end-to-end delay and start-up delay when employing several connections. Results show that provided the TDD frame size is selected appropriately then using multiple connections preserves video quality and improves wireless channel utilization, with a minimal impact on end-to-end delay. As a trade-off, there is an increase in start-up delay arising from the need to avoid possible buffer underflow.
How Fields are Used in Java: An Empirical Study

The information hiding principle is generally accepted as one that if followed leads to higher quality software than if it is not followed. To follow the information hiding principle in object-oriented designs the advice is to avoid non-private fields. There is, however, little empirical evidence as to whether or not this advice is being followed. This paper presents the results of an empirical study of 100 open-source Java applications to determine to what degree non-private fields are declared, and to what extend they are used. The study indicates that it is not uncommon (albeit not that terribly common) to declare non-private fields, but then not take advantage of that access.
Detection and labeling of bad moves for coaching go

The level of computer programs has now reached professional strength for many games, even for the game of Go recently. A more difficult task for computer intelligence now is to create a program able to coach human players, so that they can improve their play. In this paper, we propose a method to detect and label the bad moves of human players for the game of Go. This task is challenging because even strong human players only agree at a rate of around 50% about which moves should be considered as bad. We use supervised learning with features largely available in many Go programs, and we obtain an identification level close to the one observed between strong human players. Also, an evaluation by a professional player shows that our method is already useful for intermediate-level players.
Torque modeling and analysis of spherical cctuators with iron stator

This paper presents a ball-joint-like three-degree-of-freedom (3-DOF) permanent magnet (PM) spherical actuator which features a ball-shaped rotor with multiple PM poles and a spherical iron stator with air-core coils. Torque output of this PM spherical actuator is formulated analytically. Based on the torque model, simulation result of the actuator torque variation is presented. In addition, the effect of the stator iron on the torque output is evaluated.
Up-regulation of BMP2/4 signaling increases both osteoblast-specific marker expression and bone marrow adipogenesis in Gja1Jrt/+ stromal cell cultures

Up-regulation of BMP2/4 signaling in trabecular bone and/or stromal cells increases osteoblast-specific marker expression in hyperactive Gja1Jrt/+ osteoblasts and may also increase bone marrow adipogenesis by up-regulation of Pparg2 in the Cx43-deficient Gja1Jrt/+ mouse model.
MOLECULAR EVOLUTION, ADAPTIVE RADIATION, AND GEOGRAPHIC DIVERSIFICATION IN THE AMPHIATLANTIC FAMILY RAPATEACEAE: EVIDENCE FROM ndhF SEQUENCES AND MORPHOLOGY

Abstract Rapateaceae (16 genera, ∼100 species) is largely restricted to the tepuis and sandplains of the Guayana Shield in northern South America, with Maschalocephalus endemic to West Africa. The family has undergone extensive radiation in flower form, leaf shape, habit, and habitat. To analyze the evolution of these distributions and traits, we derived a molecular phylogeny for representatives of 14 genera, based on sequence variation in the chloroplast-encoded ndhF gene. The lowland subfamily Rapateoideae is paraphyletic and includes the largely montane subfamily Saxofridericioideae as a monophyletic subset. Overall, the morphological/anatomical data differ significantly from ndhF sequences in phylogenetic structure, but show a high degree of concordance with the molecular tree in three of four tribes. Branch lengths are consistent with the operation of a molecular clock. Maschalocephalus diverges only slightly from other Monotremae: it is the product of relatively recent, long-distance dispersal, not continental drift—only its habitat atop rifted, nutrient-poor sandstones is vicariant. The family appears to have originated approximately 65 Mya in inundated lowlands of the Guayana Shield, followed by: (1) wide geographic spread of lowland taxa along riverine corridors; (2) colonization of Amazonian white-sand savannas in the western Shield; (3) invasion of tepui habitats with frequent speciation, evolution of narrow endemism, and origin of hummingbird pollination in the western Shield; and (4) reinvasion of lowland white-sand savannas. The apparent timing of speciation in the Stegolepis alliance about 6–12 Mya occurred long after the tepuis began to be dissected from each other as the Atlantic rifted approximately 90 Mya. Given the narrow distributions of most montane taxa, this suggests that infrequent long-distance dispersal combined with vicariance accounts for speciation atop tepuis in the Stegolepis alliance. Editor: K. Holsinger
Identification of Cytoskeleton-Associated Proteins Essential for Lysosomal Stability and Survival of Human Cancer Cells

Microtubule-disturbing drugs inhibit lysosomal trafficking and induce lysosomal membrane permeabilization followed by cathepsin-dependent cell death. To identify specific trafficking-related proteins that control cell survival and lysosomal stability, we screened a molecular motor siRNA library in human MCF7 breast cancer cells. SiRNAs targeting four kinesins (KIF11/Eg5, KIF20A, KIF21A, KIF25), myosin 1G (MYO1G), myosin heavy chain 1 (MYH1) and tropomyosin 2 (TPM2) were identified as effective inducers of non-apoptotic cell death. The cell death induced by KIF11, KIF21A, KIF25, MYH1 or TPM2 siRNAs was preceded by lysosomal membrane permeabilization, and all identified siRNAs induced several changes in the endo-lysosomal compartment, i.e. increased lysosomal volume (KIF11, KIF20A, KIF25, MYO1G, MYH1), increased cysteine cathepsin activity (KIF20A, KIF25), altered lysosomal localization (KIF25, MYH1, TPM2), increased dextran accumulation (KIF20A), or reduced autophagic flux (MYO1G, MYH1). Importantly, all seven siRNAs also killed human cervix cancer (HeLa) and osteosarcoma (U-2-OS) cells and sensitized cancer cells to other lysosome-destabilizing treatments, i.e. photo-oxidation, siramesine, etoposide or cisplatin. Similarly to KIF11 siRNA, the KIF11 inhibitor monastrol induced lysosomal membrane permeabilization and sensitized several cancer cell lines to siramesine. While KIF11 inhibitors are under clinical development as mitotic blockers, our data reveal a new function for KIF11 in controlling lysosomal stability and introduce six other molecular motors as putative cancer drug targets.
Energy- and Cost-Efficient Mobile Communication Using Multi-Cell MIMO and Relaying

In this paper, relaying and multi-cell MIMO transmission are investigated as approaches for improving resource reuse and more flexible organization of cellular networks. The analysis focuses on approaches for future cellular systems, which jointly exploit relaying and multi-cell MIMO transmission. Possible candidate approaches are identified, simplified for practical applications and evaluated using a system-level model from the European research project WINNER. Their achievable throughput is analyzed under practical constraints using three different normalization approaches: cost-normalization, energy-normalization, and joint cost-energy-normalization. It can be shown that the combined approach of relaying and multi-cell MIMO provides significant gains for the uplink communication. The selected approach exploits cooperative multi-cell MIMO processing between base stations and relay nodes, and uses a resource coordination technique on the links between relay nodes and user terminals. If a relay-based deployment is subject to a cost- and energy-normalization, multi-cell MIMO outperforms relaying with respect to achievable downlink throughput.
LAR-1-Affirmative Effects with TCP on Energy-Conservation in Ad-Hoc Network

1 Electronics and communication engineering Dept. UIT,RGPV,Bhopal (M.P.)-India, e-mail neelesh.9826@gmail.com 2 HOD,Information Technology Dept. UIT,RGPV,Bhopal (M.P.)-India, e-mail roopamgupta@rgtu.net Abstract – Presently accelerating the energyconservation in Mobile Ad-Hoc Networks (MANETs) has been a herculean task. The LAR-1 (Location-Aided Routing-1) position-based routing scheme in network has recently invoked interest in the domain of energyconservation as it extends the network lifetime of the networks. This paper has especially studied and investigated the N-LAR-1 (New-LAR-1) methodology given via TCP packets for reliability and security in AdHoc network. TCP with ACK signals is frequently used in the field of data streaming or communication than UDP. Prominent results have been accomplished through same routing approach by utilizing the sleep mode condition of mobile nodes in Ad-Hoc Network. Thorough analysis of performance metrics using the above mentioned approach have been reported with TCP-Reno, TCP-New Reno, TCP-Vegas and TCPSACK. An exemplary result from TCP-Vegas and TCPNew Reno is being achieved in this paper.
The benefits of using a walking interface to navigate virtual environments

Navigation is the most common interactive task performed in three-dimensional virtual environments (VEs), but it is also a task that users often find difficult. We investigated how body-based information about the translational and rotational components of movement helped participants to perform a navigational search task (finding targets hidden inside boxes in a room-sized space). When participants physically walked around the VE while viewing it on a head-mounted display (HMD), they then performed 90% of trials perfectly, comparable to participants who had performed an equivalent task in the real world during a previous study. By contrast, participants performed less than 50% of trials perfectly if they used a tethered HMD (move by physically turning but pressing a button to translate) or a desktop display (no body-based information). This is the most complex navigational task in which a real-world level of performance has been achieved in a VE. Behavioral data indicates that both translational and rotational body-based information are required to accurately update one's position during navigation, and participants who walked tended to avoid obstacles, even though collision detection was not implemented and feedback not provided. A walking interface would bring immediate benefits to a number of VE applications.
Generating Private Recommendations Efficiently Using Homomorphic Encryption and Data Packing

Recommender systems have become an important tool for personalization of online services. Generating recommendations in online services depends on privacy-sensitive data collected from the users. Traditional data protection mechanisms focus on access control and secure transmission, which provide security only against malicious third parties, but not the service provider. This creates a serious privacy risk for the users. In this paper, we aim to protect the private data against the service provider while preserving the functionality of the system. We propose encrypting private data and processing them under encryption to generate recommendations. By introducing a semitrusted third party and using data packing, we construct a highly efficient system that does not require the active participation of the user. We also present a comparison protocol, which is the first one to the best of our knowledge, that compares multiple values that are packed in one encryption. Conducted experiments show that this work opens a door to generate private recommendations in a privacy-preserving manner.