Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanical properties of ceramic structures based on Triply Periodic Minimal Surface (TPMS) processed by 3D printing

Repairing tissues and organs has been the main goal of surgical procedures. Since the 1990s, the main goal of tissue engineering has been reparation, using porous scaffolds that serve as a three-dimensional template for the initial fixation of cells and subsequent tissue formation both in vitro and in vivo. A scaffold must have specific characteristics of porosity, interconnectivity, surface area, pore volume, surface tortuosity, permeability and mechanical properties, which makes its design, manufacturing and characterization a complex process. Inspired by nature, triply periodic minimal surfaces (TPMS) have emerged as an alternative for the manufacture of porous pieces with design requirements, such as scaffolds for tissue repair. In the present work, we used the technique of 3D printing to obtain ceramic structures with Gyroid, Schwarz Primitive and Schwarz Diamond Surfaces shapes, three TPMS that fulfil the geometric requirements of a bone tissue scaffold. The main objective of this work is to compare the mechanical properties of ceramic pieces of three different forms of TPMS printed in 3D using a commercial ceramic paste. In this way it will be possible to clarify which is the TPMS with appropriate characteristics to construct scaffolds of ceramic materials for bone repair. A dependence of the mechanical properties with the geometry was found being the Primitive Surface which shows the highest mechanical properties.
Pathologies of imagination in schizophrenia spectrum disorders

Patients with the schizophrenia spectrum disorders (SSD) often report intense, vivid imagery, typically designated as obsessions, ‘pseudo-obsessions’, worries, or ruminations, etc. Apparently similar phenomena may occur in other disorders such as OCD, PTSD, anxiety and affective disorders. Psychiatrists are therefore frequently exposed to such type of complaints, yet without possessing an adequate conceptual-descriptive framework at their disposal. In this editorial, we present a discussion of and a proposal for addressing the subjective structure of imagination in SSD, a proposal that is conceptually coherent with the phenomenology of disordered selfhood in SSD (1, 2) and which at the same time illustrates the phenomenological approach in psychopathology (3). The term ‘imagination’ is here used as being synonymous with ‘imagery’ and ‘phantasy’.
Using Twitter data to predict the performance of Bollywood movies

Purpose – The purpose of this paper is to address the shortcomings of limited research in forecasting the power of social media in India. Design/methodology/approach – This paper uses sentiment analysis and prediction algorithms to analyze the performance of Indian movies based on data obtained from social media sites. The authors used Twitter4j Java API for extracting the tweets through authenticating connection with Twitter web sites and stored the extracted data in MySQL database and used the data for sentiment analysis. To perform sentiment analysis of Twitter data, the Probabilistic Latent Semantic Analysis classification model is used to find the sentiment score in the form of positive, negative and neutral. The data mining algorithm Fuzzy Inference System is used to implement sentiment analysis and predict movie performance that is classified into three categories: hit, flop and average. Findings – In this study the authors found results of movie performance at the box office, which had been based .
Fabrication and Bioapplications of Magnetically Modified Chitosan-based Electrospun Nanofibers

Abstract The fabrication of magnetically modified electrospun nanocomposite fibers based on a naturally-derived biocompatible and biodegradable polysaccharide chitosan (CS) and the hydrophilic and biocompatible poly(vinylpyrrolidone) (PVP) is reported herein. The anchoring of magnetic nanoparticles (MNPs) onto the surfaces of the electrospun PVP/CS fibers was carried out by a post-magnetization process based on chemical coprecipitation, via immersing the produced fibrous mats in an aqueous solution containing Fe(II) and Fe(III) salts at appropriate molar ratios, followed by the addition of a weak base to yield MNPs. Electron microscopy revealed the presence of continuous micron and submicron fibers surface-decorated with MNPs. The magnetically modified PVP/CS fibers exhibited superparamagnetic behavior at ambient temperature. The magnetic fibrous nanocomposite carrier was employed for the immobilization of Saccharomyces cerevisiae cells and their use for sucrose hydrolysis, and Candida rugosa lipase and its use for artificial substrate hydrolysis.
Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer.

CONTEXT The selection of individuals for hereditary nonpolyposis colorectal cancer (HNPCC) genetic testing is challenging. Recently, the National Cancer Institute outlined a new set of recommendations, the revised Bethesda guidelines, for the identification of individuals with HNPCC who should be tested for microsatellite instability. OBJECTIVE To establish the most effective and efficient strategy for the detection of MSH2/MLH1 gene carriers. DESIGN, SETTING, AND PATIENTS A prospective, multicenter, nationwide study (the EPICOLON study) in 20 hospitals in the general community in Spain of 1222 patients with newly diagnosed colorectal cancer between November 1, 2000, and October 31, 2001. INTERVENTIONS Microsatellite instability testing and MSH2/MLH1 immunostaining in all patients regardless of age, personal or family history, and tumor characteristics. Patients whose tumors exhibited microsatellite instability and/or lack of protein expression underwent MSH2/MLH1 germline testing. MAIN OUTCOME MEASURES Effectiveness and efficiency of both microsatellite instability testing and immunostaining, either directly or previous selection of patients according to the revised Bethesda guidelines, were evaluated with respect to the presence of MSH2/MLH1 germline mutations. RESULTS Two hundred eighty-seven patients (23.5%) fulfilled the revised Bethesda guidelines. Ninety-one patients (7.4%) had a mismatch repair deficiency, with tumors exhibiting either microsatellite instability (n = 83) or loss of protein expression (n = 81). Germline testing identified 11 mutations (0.9%) in either MSH2 (7 cases) or MLH1 (4 cases) genes. Strategies based on either microsatellite instability testing or immunostaining previous selection of patients according to the revised Bethesda guidelines were the most effective (sensitivity, 81.8% and 81.8%; specificity, 98.0% and 98.2%; positive predictive value, 27.3% and 29.0%, respectively) to identify MSH2/MLH1 gene carriers. Logistic regression analysis confirmed the revised Bethesda guidelines as the most discriminating set of clinical parameters (odds ratio, 33.3; 95% confidence interval, 4.3-250; P = .001). CONCLUSION The revised Bethesda guidelines constitute a useful approach to identify patients at risk for HNPCC. In patients fulfilling these criteria, both microsatellite instability testing and immunostaining are equivalent and highly effective strategies to further select those patients who should be tested for MSH2/MLH1 germline mutations.
Prediction of an Optimum Biodiesel-Diesel Blended Fuel for Compression Ignition Engine Using GT-Power

This paper describes the development of a turbocharged direct-injection compression ignition (CI) engine model using fluid-dynamic engine simulation codes through a simulating tool known as GT Power. The model was first fueled with diesel, and then with various blends of biodiesel and diesel by allotting suitable parameters to predict an optimum blended fuel. During the optimization, main focus was on the engine performance, combustion, and one of the major regulated gaseous pollutants known as oxides of nitrogen (NOx). The combustion parameters such as Premix Duration (DP), Main Duration (DM), Premix Fraction (FP), Main Exponent (EM) and ignition delay (ID) affect the start of injection (SOI) angle, and thus played significant role in the prediction of optimum blended fuel. The SOI angle ranging from 5.2 to 5.7 degree crank angle (DCA) measured before top dead center (TDC) revealed an optimum biodiesel-diesel blend known as B20 (20% biodiesel and 80% diesel by volume). B20 exhibited the minimum possible NOx emissions, better combustion and acceptable engine performance. Moreover, experiments were performed to validate the simulated results by fueling the engine with B20 fuel and operating it on AC electrical dynamometer. Both the experimental and simulated results were in good agreement revealing maximum deviations of only 3%, 3.4%, 4.2%, and 5.1% for NOx, maximum combustion pressure (MCP), engine brake power (BP), and brake specific fuel consumption (BSFC), respectively. Meanwhile, a positive correlation was found between MCP and NOx showing that both the parameters are higher at lower speeds, relative to higher engine speeds.
Improved MIMO performance with non-orthogonal space-time block codes

Transmission over multiple input multiple output (MIMO) radio channels is considered. When multiple Rx antennas are present, one may simultaneously increase the rate and improve performance by optimizing transmit diversity, using nonorthogonal space-time block codes. This improves the performance of MIMO systems considerably, especially when the number of Tx and Rx antennas is small. As an example, we consider a 2 Tx, 2 Rx system, and construct a 2×2 nonorthogonal space-time block code with symbol rate 2, which performs 2.5 dB better than the corresponding BLAST system at BER 10-3.
MATR 3 disruption in human and mouse associated with bicuspid aortic valve , aortic coarctation and patent ductus arteriosus

Cardiac left ventricular outflow tract (LVOT) defects represent a common but heterogeneous subset of congenital heart disease for which gene identification has been difficult. We describe a 46,XY,t(1;5)(p36.11;q31.2)dn translocation carrier with pervasive † F.Q. -R. and Q.J.X. contributed equally to this work. ‡ Present address: Genetics Disease Research Branch, NHGRI, Bethesda, MD, USA. ¶ Present address: Department of Pharmacology, Yonsei University College of Medicine, Seoul, South Korea. § Present address: Department of Pathology, University of Massachusetts, Worcester, UK. || Present address: Cardiology, Nationwide Children’s Hospital, Columbus, OH. Received: November 29, 2014. Revised: December 29, 2014. Accepted: January 5, 2015 © The Author 2015. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Human Molecular Genetics, 2015, Vol. 24, No. 8 2375–2389 doi: 10.1093/hmg/ddv004 Advance Access Publication Date: 7 January 2015
Flow of information for emotions through temporal and orbitofrontal pathways

The posterior orbitofrontal cortex, anterior temporal sensory association areas and the amygdala have a key role in emotional processing and are robustly interconnected. By analogy with the pattern of connections in early processing sensory areas, anterior temporal sensory and polymodal association cortices send primarily feedforward projections to posterior orbitofrontal cortex and to the amygdala originating in the supragranular layers, in pathways that may provide signals about the external environment. The amygdala innervates all layers of the posterior orbitofrontal cortex, including the middle, or feedforward, target layers, in a pathway that may convey information about emotional context. The posterior orbitofrontal cortex targets dual systems in the amygdala which have opposite effects on central autonomic structures. Both pathways originate in posterior orbitofrontal cortex, but one targets heavily the inhibitory intercalated masses, whose activation can ultimately disinhibit central autonomic structures during emotional arousal. The other pathway innervates the central nucleus of the amygdala, and can lead to downstream inhibition of central autonomic structures, resulting in autonomic homeostasis. The choice of pathway may depend on emotional context, and probably involves other prefrontal areas, including lateral prefrontal areas, which have executive functions. Lateral prefrontal cortices issue feedforward projections that target layer 5 of orbitofrontal cortex, which is the chief output layer to the amygdala. These laminar‐specific pathways suggest sequential and collaborative interactions in evaluating the sensory and emotional aspects of the environment for decision and action in complex behaviour.
A proposal of the marriage of Encyclopedic and Commonsense Knowledge

Commonsense Knowledge (lexical + common knowledge) and Encyclopedic knowledge helps in different situations because one is about entities and other is about named entities. We set up a principled experiment to empirically verify that for real world scenarios, it is best to have a marriage of the types of knowledge. We envision WordNet to be the mediator between these two systems just like Wikipedia is the mediator in linked open data. For this purpose the Yago ontology would be helpful as well.
Uncertainty, Posttraumatic Stress, and Health Behavior in Young Adult Childhood Cancer Survivors

Background: Young adult survivors of childhood cancer are at risk for medical late effects, some of which can be managed through health promotion behaviors. However, chronic uncertainty about the future can lead to the development of posttraumatic stress symptoms (PTSS) that can interfere with health promotion behaviors. Objectives: To test a mediating model for the relationships among uncertainty, PTSS, and health promotion behaviors in young adult survivors of childhood cancer. Methods: The design was cross-sectional correlational. A convenience sample was used, and the data were collected using a mailed survey. Study measures included the Mishel Uncertainty in Illness Scale-Community Form, the Posttraumatic Stress Disorder Index, and the Health Promoting Lifestyle Profile II. Results: Forty-six (51.1%) of the eligible survivors responded to the invitation to participate in the study. The analysis was based on data from 45 survivors. The results show that the relationship between PTSS and health promotion behaviors was mediated by uncertainty. Discussion: Uncertainty is a suitable target for theory-based nursing interventions used to boost health promotion behaviors in young adult survivors of childhood cancer.
BiCov: a novel image representation for person re-identification and face verification

This paper proposes a novel image representation which can properly handle both background and illumination variations. It is therefore adapted to the person/face reidentification tasks, avoiding the use of any additional pre-processing steps such as foreground-background separation or face and body part segmentation. This novel representation relies on the combination of Biologically Inspired Features (BIF) and covariance descriptors used to compute the similarity of the BIF features at neighboring scales. Hence, we will refer to it as the BiCov representation. To show the effectiveness of BiCov, this paper conducts experiments on two person re-identification tasks (VIPeR and ETHZ) and one face verification task (LFW), on which it improves the current state-of-the-art performance.
Diverse processing in cochlear spaced sub-bands for multi-microphone adaptive speech enhancement in reverberant environments

A multi-microphone sub-band adaptive speech enhancement scheme using a human cochlear model is presented. The effect of distributing the sub-bands non-linearly as in humans is investigated. A new robust metric is developed in order to automatically select the best form of diverse processing within each sub-band. Comparative results achieved in simulation experiments demonstrate that the proposed scheme employing diverse processing in cochlear spaced sub-bands is capable of significantly outperforming conventional noise cancellation schemes.
The relation of positive emotions to post partum depression

Positive emotions have been implicated in the development of coping resources and resilience for psychological health across various significant life events. Childbirth is often an event that incites positive emotions in a woman, and it may be that such emotions have an immobilizing effect on the onset of post natal depressive symptoms. In efforts to examine the influence of positive emotions on women during their transition into motherhood, the present study assessed 195 women across two stages: before and after childbirth. The aim of the study was to examine the variety of positive emotions that arise from childbirth, the relationship of positive emotions that arise from childbirth to maternity and other demographic variables and the relation between positive emotions that arise from childbirth and depressive post natal symptoms. Results revealed a significant manifestation of specific positive emotions such as joyfulness, pride, and interest after childbirth. Participants between the ages of 30 and 34 experienced a greater variety and intensity of positive emotions before and after. In turn, a negative relationship was found between the experience of positive emotion intensity and post natal depressive symptomatology. Factors such as education level, whether the birth was planned or not, and environmental and partner support were found to relate significantly to the manifestation of positive emotions.
The Ninapro database: A resource for sEMG naturally controlled robotic hand prosthetics

The dexterous natural control of robotic prosthetic hands with non-invasive techniques is still a challenge: surface electromyography gives some control capabilities but these are limited, often not natural and require long training times; the application of pattern recognition techniques recently started to be applied in practice. While results in the scientific literature are promising they have to be improved to reach the real needs. The Ninapro database aims to improve the field of naturally controlled robotic hand prosthetics by permitting to worldwide research groups to develop and test movement recognition and force control algorithms on a benchmark database. Currently, the Ninapro database includes data from 67 intact subjects and 11 amputated subject performing approximately 50 different movements. The data are aimed at permitting the study of the relationships between surface electromyography, kinematics and dynamics. The Ninapro acquisition protocol was created in order to be easy to be reproduced. Currently, the number of datasets included in the database is increasing thanks to the collaboration of several research groups.
Dependency parsing for Chinese long sentence: A second-stage main structure parsing method

This paper explores the problem of parsing Chinese long sentences. Inspired by human sentence processing, a second-stage parsing method, referred as main structure parsing in this paper, are proposed to improve the parsing performance as well as maintaining its high accuracy and efficiency on Chinese long sentences. Three different methods have attempted in this paper and the result shows that the best performance comes from the method using Chinese comma as the boundary of the sub sentence. According to our experiment about testing on the Chinese dependency Treebank 1.0 data, it improves long dependency accuracy by around 6.0% than the baseline parser and 3.2% than the previous best model.
Confirmation of association of IL‐15 with pediatric asthma and comparison of different controls

Background: Interleukin (IL)‐15 is an important mediator in chronic inflammatory diseases. Recently, we have described the association of IL‐15 haplotypes with bronchial asthma. Asthma genetics is highly complex – about every second candidate gene is not confirmed in consecutive studies. We were interested in whether association of asthma with IL‐15 holds in a second population. Furthermore, we sought to investigate the effect of different controls.
in Human Cancer Cells Genetic Unmasking of an Epigenetically Silenced microRNA

The mechanisms underlying microRNA (miRNA) disruption in human disease are poorly understood. In cancer cells, the transcriptional silencing of tumor suppressor genes by CpG island promoter hypermethylation has emerged as a common hallmark. We wondered if the same epigenetic disruption can ‘‘hit’’ miRNAs in transformed cells. To address this issue, we have used cancer cells genetically deficient for the DNA methyltransferase enzymes in combination with a miRNA expression profiling. We have observed that DNA hypomethylation induces a release of miRNA silencing in cancer cells. One of the main targets is miRNA-124a, which undergoes transcriptional inactivation by CpG island hypermethylation in human tumors from different cell types. Interestingly, we functionally link the epigenetic loss of miRNA-124a with the activation of cyclin D kinase 6, a bona fide oncogenic factor, and the phosphorylation of the retinoblastoma, a tumor suppressor gene. [Cancer Res 2007;67(4):1424–9]
β‐Amyloid inhibits NOS activity by subtracting NADPH availability

The amyloid peptides Aβ1–42 and Aβ25–35 strongly inhibited the activity of constitutive neuronal and endothelial nitric oxide synthases (i.e., NOS‐I and NOS‐III, respectively) in cell‐free assays. The molecular mechanism of NOS inhibition by Aβ fragments was studied in detail with Aβ25–35. The inhibitory ability was mostly NADPH‐dependent and specific for the soluble form of Aβ25–35. Optical, fluorescence, and NMR spectroscopy showed that the soluble, but not aggregated, Aβ25–35 interacted with NADPH, thus suggesting that a direct recruitment of NADPH may result in diminished availability of the redox cofactor for NOS functioning. To assess the physiological relevance of our findings, rat neuronal‐like PC12 and glioma C6 cell lines were used as cellular models. After Aβ25–35 internalization into cells was verified, the activity of constitutive NOS was measured using the DAF‐2DA detection system and found to be severely impaired upon Aβ25–35 uptake. Consistent with previous results on the molecular cross‐talk between NOS isoforms, repression of constitutive NOS by Aβ25–35 resulted in enhanced expression of inducible NOS (NOS‐II) mRNA in C6 cells. Our results represent the first evidence that amyloid fragments impair constitutive NOS activity in cell‐free and cellular systems, providing a possible molecular mechanism for the onset and/or maintenance of Alzheimer's disease.
An off-line signature verification system using an extracted displacement function

This paper proposes an off-line signature verification system based on a displacement extraction method in which a questionable signature is compared with a corresponding authentic one. The optimum displacement function for any pair of signatures is extracted using minimization of a functional defined as the weighted sum of the squared Euclidean distance between two signatures and a penalty term requiring smoothness of the displacement function. A coarse-to-fine search method is applied to avoid stopping at a local minimum, i.e., the two signatures are first transformed into coarse images by Gaussian filtering. The optimum displacement function is incorporated such that the system measures the dissimilarity between a questionable signature and the corresponding authentic one. The questionable signature is accepted as genuine only if the observed dissimilarity is below a threshold determined using the dissimilarity between two authentic signatures multiplied by a threshold coefficient. An experiment was performed to evaluate the effectiveness of the proposed system, with resultant error rates being as low as 24.9%; a level much better than that obtained by a method utilizing no displacement function.