Miracle-dz/UniFAR-FTUs huggingface dataset:
Food Inflation and Passenger Vehicle Purchases in South Africa: Cointegration, Short Run Dynamics and Causality

Food inflation in South Africa has been observed to be a major source of underlying inflationary pressures in the economy due to its persistence beyond that of other commodities. In this regard, this study investigated whether an increase in the prices of food products has a significant effect on passenger vehicle purchases in South Africa. The Phillip-Perron (PP) test, showed vehicle purchases to be stationary in level while food inflation was stationary in the first difference. Using secondary time series data, the Johansen cointegration test revealed that the variables in the vehicle purchase function were cointegrated in the long run. The vector error correction model showed a long-run relationship, albeit insignificant, between food inflation and vehicle purchases. There was no evidence of a short run relationship between the two variables. The Granger causality test revealed no causal effect between the variables, regardless of the direction of the test. The study concluded that an increase in the prices of food products will not play a considerable role in consumersâ€™ vehicle purchase decisions in South Africa. These results have policy implications for the motor and related industries.
Introduction: the role of agricultural technologies in tropical deforestation.

This introductory chapter sets the scene for the discussion in the edited volume on how new agricultural affects tropical forests. It critically reviews four hypotheses that have been central in the claim that better technologies help protect forests: the Borlaug, the subsistence, the economic development and the land degradation-deforestation hypotheses. Each of them appears to be valid only under certain restrictive conditions. The chapter then gives the aims and scope of the book, the key conclusions, as well as a summary of each of the chapters. A key objective of the book is to identify which technologies under which conditions lead to a win-win situation or trade-off between forest conservation and increasing farm productivity.
Psychological selection of Antarctic personnel: the "SOAP" instrument.

INTRODUCTION The potential advantage of including a psychological test battery in the selection process for service in the Antarctic was examined in 348 applicants for employment in Antarctica with the British Antarctic Survey (BAS). METHODS Applicants were screened with the Selection of Antarctic Personnel battery (SOAP) consisting of nine well-known psychological instruments. The SOAP scores were not revealed to the BAS selection panel members, who based the selection on operational criteria, interview, and a general medical examination. The SOAP scores of those selected (n = 177) were further compared with station commanders' reports of winter adaptation (n = 140), and subjective health complaints (SHC) (n = 86). RESULTS There were no significant agreements between SOAP scores (n = 348) and those actually selected by the BAS panel (121 accepted, 227 not accepted) (Cohen's Kappas for inter-rater agreement < 0.20). Participants characterized as exceptionally well adapted by the station commanders had higher scores on Openness on the NEO-FFI (the "Big Five" personality inventory) [Odds Ratio (OR) = 5.2], and higher levels of Emotion-Focused Coping (OR = 2.7) and fewer SHC (OR = 0.3). Participants rated by station commanders as "poor" had higher levels of Defensive Hostility (OR = 4.2), and lower levels of Emotion-Focused Coping (OR = 0.3). Women had higher rates of success in service than men, but were less likely to be selected. DISCUSSION AND CONCLUSION Adding a psychological test battery would improve the odds of selecting good performers, and reduce the odds of selecting poor performers.
Pulmonary hypertension specific treatment in infants with bronchopulmonary dysplasia

When bronchopulmonary dysplasia (BPD) is complicated by pulmonary hypertension (PH), morbidity and mortality are significantly increased. BPD‐associated PH is not included in the current indications for PH medications. However, limited data demonstrate hemodynamic improvement and decreased mortality with PH‐specific treatment. This report describes our 6‐year experience treating BPD‐associated PH with PH medications, mainly sildenafil.
‘I am assumed to be someone who doesn’t have to deal with diversity’: countering the denial of diversity in rural teacher education

Abstract In this article, the researchers examine the role of diversity in a pre-service teacher education programme in a predominately white public university in the United States rural north-west region. Using ethnographic and autoethnographic methods, one professor and four pre-service education students from across early childhood, primary and secondary education examine how issues of diversity are addressed in coursework and practicum teaching experiences. Findings reveal a pervasive discourse of denying diversity in the rural landscape, limited programmatic engagement with diversity as a body of knowledge and skill set for teaching and course interactions which thwart teachers’ abilities to address inequity in dynamic communities, locally and globally. We counter these limitations by proposing rural universities engage with pre-service teachers in reflective dialogue as critical stakeholders in (re)conceptualizing rurality as diverse, and as co-partners in mapping increased attention to culturally relevant education as an applied stance in a dynamic and changing democracy.
The community philanthropic foundation: A new form of independent public service provider for China?

There have been growing calls for new theories understand public governance with respect to service provision collaboration involving nonprofit and for-profit actors. In this article, we develop a framework for analyzing whether and how independent public service providers change cross-sector collaboration. We examine new forms of collaboration in nonprofit organizations in China. Based on a discussion of the effectiveness of public service delivery by community philanthropic foundations in three Chinese cities, our analysis reveals that the new type of collaboration entities are attempting to meet unfulfilled public needs. Outside the government’s hierarchical structure, nonprofit and for-profit actors jointly form independent organizations to address public issues. However, because public governance systems are more centralized in China than in many Western countries, the country faces major challenges in the production and delivery of public goods and in implementing service reforms. This article extends the existing research discourse on public governance and cross-sector collaboration.
Women Empowerment Through Self-Help Groups: The Bittersweet Fruits of Collective Apple Cultivation in Highland Ethiopia

Abstract This paper deals with the impact of self-help groups (SHGs) in apple production on empowering women in the Chencha district of Southern Ethiopia. Impact is traced on the basis of a cross-sectional survey among SHG members and nonmembers, using propensity score matching. Apart from the attitudinal changes among SHG and non-SHG women, we also scrutinize differences in male attitudes concerning the status of women. The results point towards positive and significant impacts of SHG participation on empowerment at the community level, which suggests that SHGs offer an effective space for women to share information and raise awareness about their rights. This could in turn be harnessed collectively to negotiate more “room to maneuver” in the community. At the same time, however, the data hint at negative effects from group participation at the household level. The attitudinal differences between treatment and control group indicate more conflictive relations between spouses, arguably due to an intensified fight to assert control over household resources. Hence, the evidence is consistent with a potential “backlash effect” from husbands.
Optimization of exposure in panoramic radiography while maintaining image quality using adaptive filtering

Abstract Objective The purpose of the present study was to investigate the potential of using advanced external adaptive image processing for maintaining image quality while reducing exposure in dental panoramic storage phosphor plate (SPP) radiography. Materials and methods Thirty-seven SPP radiographs of a skull phantom were acquired using a Scanora panoramic X-ray machine with various tube load, tube voltage, SPP sensitivity and filtration settings. The radiographs were processed using General Operator Processor (GOP) technology. Fifteen dentists, all within the dental radiology field, compared the structural image quality of each radiograph with a reference image on a 5-point rating scale in a visual grading characteristics (VGC) study. The reference image was acquired with the acquisition parameters commonly used in daily operation (70 kVp, 150 mAs and sensitivity class 200) and processed using the standard process parameters supplied by the modality vendor. Results All GOP-processed images with similar (or higher) dose as the reference image resulted in higher image quality than the reference. All GOP-processed images with similar image quality as the reference image were acquired at a lower dose than the reference. This indicates that the external image processing improved the image quality compared with the standard processing. Regarding acquisition parameters, no strong dependency of the image quality on the radiation quality was seen and the image quality was mainly affected by the dose. Conclusions The present study indicates that advanced external adaptive image processing may be beneficial in panoramic radiography for increasing the image quality of SPP radiographs or for reducing the exposure while maintaining image quality.
Estimation of Quantitative Trait Locus Effects with Epistasis by Variational Bayes Algorithms

Bayesian hierarchical shrinkage methods have been widely used for quantitative trait locus mapping. From the computational perspective, the application of the Markov chain Monte Carlo (MCMC) method is not optimal for high-dimensional problems such as the ones arising in epistatic analysis. Maximum a posteriori (MAP) estimation can be a faster alternative, but it usually produces only point estimates without providing any measures of uncertainty (i.e., interval estimates). The variational Bayes method, stemming from the mean field theory in theoretical physics, is regarded as a compromise between MAP and MCMC estimation, which can be efficiently computed and produces the uncertainty measures of the estimates. Furthermore, variational Bayes methods can be regarded as the extension of traditional expectation-maximization (EM) algorithms and can be applied to a broader class of Bayesian models. Thus, the use of variational Bayes algorithms based on three hierarchical shrinkage models including Bayesian adaptive shrinkage, Bayesian LASSO, and extended Bayesian LASSO is proposed here. These methods performed generally well and were found to be highly competitive with their MCMC counterparts in our example analyses. The use of posterior credible intervals and permutation tests are considered for decision making between quantitative trait loci (QTL) and non-QTL. The performance of the presented models is also compared with R/qtlbim and R/BhGLM packages, using a previously studied simulated public epistatic data set.
Evidence for rapid evolutionary change in an invasive plant in response to biological control

We present evidence that populations of an invasive plant species that have become re‐associated with a specialist herbivore in the exotic range through biological control have rapidly evolved increased antiherbivore defences compared to populations not exposed to biocontrol. We grew half‐sib families of the invasive plant Lythrum salicaria sourced from 17 populations near Ottawa, Canada, that differed in their history of exposure to a biocontrol agent, the specialist beetle Neogalerucella calmariensis. In a glasshouse experiment, we manipulated larval and adult herbivory to examine whether a population's history of biocontrol influenced plant defence and growth. Plants sourced from populations with a history of biocontrol suffered lower defoliation than naïve, previously unexposed populations, strongly suggesting they had evolved higher resistance. Plants from biocontrol‐exposed populations were also larger and produced more branches in response to herbivory, regrew faster even in the absence of herbivory and were better at compensating for the impacts of herbivory on growth (i.e. they exhibited increased tolerance). Furthermore, resistance and tolerance were positively correlated among genotypes with a history of biocontrol but not among naïve genotypes. Our findings suggest that biocontrol can rapidly select for increased defences in an invasive plant and may favour a mixed defence strategy of resistance and tolerance without an obvious cost to plant vigour. Although rarely studied, such evolutionary responses in the target species have important implications for the long‐term efficacy of biocontrol programmes.
Mycophenolate‐based graft versus host disease prophylaxis is not inferior to methotrexate in myeloablative‐related donor stem cell transplantation

We retrospectively reviewed 242 patients who received related donor myeloablative peripheral blood hematopoietic cell transplantation. We compared patients who received mycophenolate (MMF)/cyclosporine (CSA) (n = 71), to historical controls who received methotrexate (MTX)/CSA (n = 172). There were no differences in overall survival, nonrelapse mortality, and relapse. The MMF/CSA group had significantly faster neutrophil and platelet engraftment: medians of 13 versus 18 days and 10 versus 14 days, respectively (P = 0.001). The cumulative incidence of acute graft versus host disease (GVHD) (Grades, 2–4) was significantly lower in the MMF/CSA group (45.1 vs. 74.4%, P < 0.001). The MMF/CSA group showed a lower incidence of skin (51.5 vs. 72.1%, P < 0.001) and liver acute GVHD (11.3 vs. 54.2%, P < 0.001) and a higher incidence of lung (42.2 vs. 19.0%, P = 0.045), eye (59.7 vs. 30.1%, P < 0.001), and mouth (72.8 vs. 56.4%, P = 0.001) chronic GVHD but only eye chronic GVHD was confirmed in propensity score matching (PSM) analysis. The incidence of cytomegalovirus (CMV) viremia was higher in the MMF/CSA group (55.8 vs. 39.6%, P < 0.001) but this was not confirmed in PSM analysis. MMF/CSA was identified as an independent favorable factor for acute GVHD (P < 0.001, hazard ratio, 0.41) but as a possible adverse risk factor for CMV viremia as this was not found to be statistically significant in PSM analysis. MMF/CSA in myeloablative matched related donor peripheral blood stem cell transplant is not inferior as GVHD prophylaxis in comparison with MTX/CSA and is associated with faster engraftment but a potentially higher risk of CMV viremia.Am. J. Hematol. 90:392–399, 2015. © 2015 Wiley Periodicals, Inc.
Predictors of the placebo analgesia response in randomized controlled trials of chronic pain: a meta-analysis of the individual data from nine industrially sponsored trials

Abstract A large number of analgesics have failed to prove superiority over placebo in randomized controlled trials (RCTs), and as this has been related to increasing placebo responses, there is currently an interest in specifying predictors of the placebo response. The literature on placebo mechanisms suggests that factors related to patients' expectations of treatment efficacy are pivotal for the placebo response. Also, general characteristics of RCTs have been suggested to influence the placebo response. Yet, only few meta-analyses have directly tested these hypotheses. Placebo data from 9 industrially sponsored, randomized, double-blind, placebo-controlled, multicenter phase III trials in 2017 adult patients suffering from chronic painful osteoarthritis (hip or knee) or low back pain were included. The primary outcome was pain intensity. Based on previous studies, we chose 3 expectancy-related primary predictors: type of active medication, randomization ratio, and number of planned face-to-face visits. In addition, explorative analyses tested whether RCT and patients' characteristics predicted the placebo response. Opioid trials, a high number of planned face-to-face visits, and randomization ratio predicted the magnitude of the placebo response, thereby supporting the expectancy hypothesis. Exploratory models with baseline pain intensity, age, washout length, and discontinuation because of adverse events accounted for approximately 10% of the variability in the placebo response. Based on these results and previous mechanisms studies, we think that patients' perception of treatment allocation and expectations toward treatment efficacy could potently predict outcomes of RCTs.
Dickkopf Homologs in Squamous Mucosa of Esophagitis Patients Are Overexpressed Compared with Barrett's Patients and Healthy Controls

OBJECTIVES:Esophageal mucosal response to acid exposure varies from minimal changes to erosions/ulcerations and Barrett's metaplasia. While differences in acid contact time have been suggested, the reason for these different responses is not completely understood. The aim of this study was to identify and compare gene expression differences between normal distal and proximal squamous esophageal mucosa (SM) in esophagitis patients with that of healthy controls and Barrett's patients.METHODS:Gene microarray was performed on laser-capture microdissected epithelial cells isolated from biopsy specimens followed by real-time PCR. The effect of acidic pH (pH 4.5) on Dickkopf Homolog 1 (Dkk-1) expression in the human esophageal epithelial cell line (Het-1A) was determined.RESULTS:Gene microarray analysis demonstrated that the upregulation of five genes in the distal compared with the proximal SM in esophagitis patients was greater than the healthy controls and Barrett's patients. Overexpression of Dkk-1 and Dkk-4 was further confirmed by real-time PCR. Dkk-1 and Dkk-4 mRNA levels in the distal SM of the esophagitis patients were 7.0- and 3.1-fold higher, respectively, than in the distal SM of the Barrett's patients and 4.1- and 4.1-fold higher than in healthy controls, respectively. Dkk-1 protein expression in the distal esophagitis SM was also higher than the Barrett's patients and healthy controls. Acidic pH exposure of Het-1A cells resulted in Dkk-1 upregulation at the level of both mRNA and protein.CONCLUSIONS:Dkk-1 and Dkk-4 may potentially be involved in the development of different injuries in response to pathological gastroesophageal acid reflux.
Forward Moments and Risk Premia Predictability

We rely on the recently established aggregation property of the second and third moments of returns to construct forward risk-neutral moments extracted from option prices. We show theoretically that according to standard affine no-arbitrage models, the forward moments should exhibit a factor structure, while the equity and the variance risk premia should also be affine functions of the same state variables. In light of this, we show that the factor extracted either from the forward variance or the forward skewness estimates exhibits strong predictability for the equity premium, both in-sample and out-of-sample. We also document that the forward skewness factor provides similar but often stronger predictability than the forward variance factor, and the combination of the two factors enhances the observed predictive performance. Finally, we find that the same forward moments factors that are designed to predict the equity premium, exhibit strong predictive power for the variance premium as well. JEL Classification: G10, G11, G12
Template-dependent 3′–5′ nucleotide addition is a shared feature of tRNAHis guanylyltransferase enzymes from multiple domains of life

The presence of an additional 5′ guanosine residue (G-1) is a unique feature of tRNAHis. G-1 is incorporated posttranscriptionally in eukarya via an unusual 3′–5′ nucleotide addition reaction catalyzed by the tRNAHis guanylyltransferase (Thg1). Yeast Thg1 catalyzes an unexpected second activity: Watson–Crick-dependent 3′–5′ nucleotide addition that occurs in the opposite direction to nucleotide addition by all known DNA and RNA polymerases. This discovery led to the hypothesis that there are alternative roles for Thg1 family members that take advantage of this unusual enzymatic activity. Here we show that archaeal homologs of Thg1 catalyze G-1 addition, in vitro and in vivo in yeast, but only in a templated reaction, i.e. with tRNAHis substrates that contain a C73 discriminator nucleotide. Because tRNAHis from archaea contains C73, these findings are consistent with a physiological function for templated nucleotide addition in archaeal tRNAHis maturation. Moreover, unlike yeast Thg1, archaeal Thg1 enzymes also exhibit a preference for template-dependent U-1 addition to A73-containing tRNAHis. Taken together, these results demonstrate that Watson–Crick template-dependent 3′–5′ nucleotide addition is a shared catalytic activity exhibited by Thg1 family members from multiple domains of life, and therefore, that this unusual reaction may constitute an ancestral activity present in the earliest members of the Thg1 enzyme family.
Impacts of altered disturbance regimes on community structure and biodiversity mediated by fecundity–tolerance interactions

We present an investigation of the effects of disturbance and fecundity–tolerance strategies on community composition. We develop a theoretical model and apply it to macrofaunal communities at deep‐sea hydrothermal vents. We characterize community outcomes and find that dominance, coexistence, and alternative stable equilibria can all result from the interplay of disturbance regimes and fecundity–tolerance interactions. We show that fecundity–tolerance trade‐offs can permit coexistence under disturbance, but a strict fecundity–tolerance trade‐off is not required for coexistence to arise. We further describe how coexistence depends on habitat availability and disturbance regimes. Generally, our model elaborates on fecundity–tolerance strategies as a new axis of trait variation in coexistence theory. Natural disturbance regimes vary considerably across regions, and anthropogenic disturbance to vent communities will escalate with the advent of deep‐sea mineral extraction. We demonstrate how anthropogenic changes to disturbance regimes may impact species diversity, pushing communities over thresholds leading to local species extinction.
Alternating Hemiplegia of Childhood: No Mutations in the Familial Hemiplegic Migraine CACNA1A Gene

Introduction Alternating hemiplegia of childhood (AHC) is a rare disorder mainly characterized by attacks of hemiplegia and mental retardation. It has been often associated with migraine. The CACNA1A gene on chromosome 19 is involved in familial hemiplegic migraine and other episodic cerebral disorders, but also with progressive neuronal damage. Methods We performed mutation analysis in this gene in four AHC patients, using single strand conformation polymorphism analysis. Results We found nine polymorphisms, but no mutations in any of the 47 exons. Conclusions Other cerebral ion channel genes remain candidate genes for AHC.