Miracle-dz/UniFAR-FTUs huggingface dataset:
A New Predictive Index for Osteoporosis in Men under 70 Years of Age: An Index to Identify Male Candidates for Osteoporosis Screening by Bone Mineral Density

Background. Bone mineral density (BMD) screening guidelines for osteoporosis in men seem to have remained unclear. We aimed to set up a predictive index for the osteoporosis(PIO) in men under 70 years of age and present the optimal cutoff value of it, so that clinicians might use it to identify male candidates who benefit from taking the BMD screening. Methods. Adult men under 70 years old who met certain criteria were included. With the determined significant predictors for osteoporosis, we created a new index that presumably best predicts the osteoporosis and compared the predictability of it to other variables. Lastly, the optimal cutoff value of the PIO was calculated. Results. A total of 359 men were included. Age, weight, and current smoking status turned out to be significant predictors for osteoporosis. The PIO was as follows: [age(years) + 10 (for current smoker)]/weight(kg). Compared to other variables, the PIO showed the greatest predictive performance with the optimal cutoff point being 0.87 at which sensitivity and specificity were 71.9% and 70.0%, respectively. Conclusion. A new predictive index appeared to predict the presence of osteoporosis fairly well and thus can be used with its cutoff point to identify men under 70 years of age who need BMD screening.
A 40–80 Gb/s PAM4 wireline transmitter in 65nm CMOS technology

This paper presents a 40–80 Gb/s quarter rate PAM4 wireline transmitter. The transmitter incorporates a 2-tap feed-forward equalizer (FFE) based on multiple-multiplex (MUX) and a parallel PRBS7 generator. The transmitter is achieved in 65nm CMOS technology and supplied with 1.2V. The simulation results show that the proposed transmitter can work at 40–80 Gb/s with 4-level pulse amplitude modulation (PAM4) and consumes 173mW at 80 Gb/s.
Automatic Term Identi cation and Classi cation in Biology Texts

The rapid growth of collections in online academic databases has meant that there is increasing di culty for experts who want to access information in a timely and e cient way. We seek here to explore the application of information extraction methods to the identi cation and classi cation of terms in biological abstracts from MEDLINE. We explore the use of a statistical method and a decision tree method for classi cation and term candidate identi cation and also a method based on shallow parsing for identi cation. Experiments are made against a corpus of 100 expert tagged abstracts and results indicate that while identifying term boundaries is non-trivial, a high success rate can be obtained in term classi cation and that a combination of methods will provide the best solution.
Tactile Motion and Pattern Processing Assessed with High-Field fMRI

Processing of motion and pattern has been extensively studied in the visual domain, but much less in the somatosensory system. Here, we used ultra-high-field functional magnetic resonance imaging (fMRI) at 7 Tesla to investigate the neuronal correlates of tactile motion and pattern processing in humans under tightly controlled stimulation conditions. Different types of dynamic stimuli created the sensation of moving or stationary bar patterns during passive touch. Activity in somatosensory cortex was increased during both motion and pattern processing and modulated by motion directionality in primary and secondary somatosensory cortices (SI and SII) as well as by pattern orientation in the anterior intraparietal sulcus. Furthermore, tactile motion and pattern processing induced activity in the middle temporal cortex (hMT+/V5) and in the inferior parietal cortex (IPC), involving parts of the supramarginal und angular gyri. These responses covaried with subjects' individual perceptual performance, suggesting that hMT+/V5 and IPC contribute to conscious perception of specific tactile stimulus features. In addition, an analysis of effective connectivity using psychophysiological interactions (PPI) revealed increased functional coupling between SI and hMT+/V5 during motion processing, as well as between SI and IPC during pattern processing. This connectivity pattern provides evidence for the direct engagement of these specialized cortical areas in tactile processing during somesthesis.
[Evaluation of the neurotoxic and nephrotoxic effects following long-term exposure to metallic mercury in employed at a chlorine/sodium-hydroxide plant].

OBJECTIVES Within the frame work of a wide multicentre study, a sub-study was developed in order to explore the occurrence of early effects on the central nervous system, on the kidney and on the neuro-immune system in the workers of a chloro-alkali production plant exposed to metallic mercury at airborne concentration levels lower than 0.025 mg/m3 (TLV-TWA). They were compared to a control population of employees of the same huge petrochemical plant with different job that did not implicate exposure to mercury vapors. Specifically, the study aimed at revealing the occurrence of early effects on the central nervous system related with mercury exposure, as can be assessed through neurophysiological and neurobehavioral tests. METHODS The excretion of urinary mercury was measured by atomic absorption spectrometry. The study of renal function was assessed by measurement of the urinary excretion of some high and low molecular weight protein markers (albumin, beta 2-microglobulin, retinol-binding protein, fibronectin, specific proximal tubule brush border antigens, N-acetyl-beta-D-glucosaminidase). The neurobehavioral status of the study subjects was assessed by means of several test parameters (Simple Reaction Time, Color Word Vigilance Test, Symbol Digit, Finger Tapping, Mood Scale of Kjellberg and Iwanowski, Subjective symptoms questionnaire (QSS), Luria Nebraska Motor Scale, Branches Alternate Movement Task and Tremometry). RESULTS The values of urinary excretion averaged 12 +/- 8 micrograms Hg/g of creatinine for the exposed workers group (n = 38), while for the reference group (n = 34 cases) urinary excretion was statistically lower, averaging 4 +/- 6 micrograms Hg/g of creatinine. Neither the parameters selected for the assessment of renal functions, nor those chosen to probe the neurobehavioral status of the probands revealed statistically reliable differences between the group of exposed workers (length of exposure: range 1-34 years) and the control group. Nevertheless, some minor but still statistically reliable correlations were found between some neurobehavioral parameters and some demographic variables describing the whole group of tested workers, but not to the level of occupational exposure to mercury. CONCLUSIONS The results of the study confirm the lack of toxic effects of clinical importance on the central nervous system and on the kidney for values of mercury urinary excretion lower than the suggested index of biological exposure (IBE) of 35 micrograms Hg/gram of creatinine.
Application of the radial basis function neural network to the prediction of log properties from seismic attributes

In this paper, we use the radial basis function neural network, or RBFN, to predict reservoir log properties from seismic attributes. We also compare the results of this approach with the use of the generalized regression neural network, GRNN, for the same problem, as proposed by Hampson et al (2001). We discuss both the theory behind these methods and the methodology involved in applying neural networks to seismic attributes. We then illustrate the method using the Blackfoot 3D seismic volume, a channel sand example from Alberta.
Text-Driven Forecasting

Forecasting the future hinges on understanding the present. The web—particularly the social web—now gives us an up-to-the-minute snapshot of the world as it is and as it is perceived by many people, right now, but that snapshot is distributed in a way that is incomprehensible to a human. Much of this data is encoded in text, which is noisy, unstructured, and sparse; yet recent developments in natural language processing now permit us to analyze text and connect it to real-world measurable phenomena through statistical models. We propose text-driven forecasting as a challenge for natural language processing and machine learning:
Knowledge and practices on malaria prevention in two rural communities in Wakiso District, Uganda.

BACKGROUND Malaria is the leading cause of morbidity and mortality in Uganda particularly among children under 5 years of age. OBJECTIVES The study assessed the knowledge and practices on malaria prevention in 2 rural communities in Wakiso District, Uganda with emphasis on the various prevention methods. METHODS The study was a cross-sectional survey carried out among 376 households using both quantitative and qualitative methods. Log-binomial regression, chi square and Spearman's rank order correlation were used to test for associations. RESULTS The majority of participants (64.6%) had low knowledge on malaria prevention methods, with untreated mosquito nets (81.7%), mosquito coils (36.9%) and insecticide treated nets (29.6%) being the most known methods. Knowledge on malaria prevention methods was associated with age (χ2 = 32.1; p < 0.01), employment status (χ2 = 18.1; p < 0.01), education (χ2 = 20.3; p = 0.01), income (χ2 = 14.5; p = 0.01) and having heard a malaria message in the previous 12 months (χ2 = 92.3; p < 0.01). Households that had at least one mosquito net were 45.5% and net ownership increased with household income. Only 0.5% of the houses had undergone indoor residual spraying in the previous 12 months, while 2.1% had complete mosquito proofing in windows and ventilators to prevent mosquito entry. CONCLUSION There is potential to improve practices on malaria prevention by targeting other methods beyond mosquito nets such as installing proofing in windows and ventilators. The integrated approach to malaria prevention which advocates the use of several malaria prevention methods in a holistic manner should be explored for this purpose.
Note on Guilt Appeals in Advertising: Covariate Effects of Self-Esteem and Locus of Control

A 1991 study by Pinto and Priest demonstrated the effectiveness of advertisements employing moderate levels of guilt in inducing guilt responses in subjects. Because individuals' responses to guilt are often influenced by their specific personality characteristics, researchers have pointed to the potential moderating effects of individual difference variables such as level of self-esteem and locus of control on individuals' susceptibility to guilt appeals. A study was conducted to evaluate the possibility that self-esteem and locus of control can act as covariates across three treatment levels of guilt advertising. From a sample of 57 working mothers, advertisements stimulating medium and high levels of guilt elicited significantly greater feelings of guilt in subjects than the control advertisement stimulating low guilt. However, the relationship between susceptibility to guilt appeals and self-esteem and locus of control was not observed to covary.
Data-driven 2D effects animation

Making plausible, high quality visual effects, like water splashes or fire, in traditional 2D animation pipelines require an animator to draw many frames of phenomena that are very difficult to recreate manually. We present a technique that uses a database of video clips of such phenomena to assist the animator. The animator has to only input sample sketched frames of the phenomena at particular time instants. These are matched to frames of the video clips and a plausible sequence of frames is generated from these clips that contain the animator drawn frames as constraints. The colour style of the hand-drawn frames is used to render the generated frames, thus resulting in a 2D animation that follows the style and intent of the 2D animator. Our system can also create multi-layered effects animation, allowing the animator to draw interacting mixed phenomena, like water being poured on fire.
Working the Boardwalk

This article argues that trust emerges as a key interactional mechanism through which vendors, artists, and performers that work in a public marketplace turn daily conditions of uncertainty into enduring stability. Drawing on four years of ethnographic data, I empirically illustrate a process of building, maintaining, and protecting trust. Following trust from the level of one-on-one interaction through to the level of a community, I expose the particular interactional work trust does for different people across different situations. In the end, the way a social psychological mechanism plays out over time has significant social and material consequences for people working under highly uncertain conditions.
Do Aesthetics Matter in Long-Established Trust?

Recently trust has gained momentum in user experience (UX) research due to the rapid development of e-commerce services, privacy and security issues. It is widely considered that the perception of trust is not only influenced by the website attributes (i.e., usability, functionality), but also by other human factors such as aesthetics. However, it is not clear that which factors of aesthetics influence what dimensions of trust while considering aesthetics and trust as multidimensional constructs. In this paper, insights from an experiment conducted with 30 participants on an e-commerce website was presented. Participants' responses on trust, aesthetics and perceived usability and user satisfaction were collected during the experiment.
Frequent Silencing of Low Density Lipoprotein Receptor-Related Protein 1B (LRP1B) Expression by Genetic and Epigenetic Mechanisms in Esophageal Squamous Cell Carcinoma

Low-density lipoprotein receptor-related protein 1B (LRP1B) is frequently deleted in tumors of various types, but its status and expression in esophageal squamous cell carcinomas (ESCs) have never been reported. In the course of a program to screen ESC cell lines for copy-number aberrations using array-based comparative genomic hybridization, we identified a homozygous deletion of LRP1B. Genomic PCR experiments revealed homozygous deletions of LRP1B in additional ESC cell lines (total, 6 of 43; 14.0%) and in primary esophageal tumors (30 of 70; 42.9%). Moreover, expression of LRP1B mRNA was frequently silenced in ESC lines without homozygous deletions (14 of 37; 37.8%). Using bisulfite-PCR analysis and sequencing, we found that LRP1B-nonexpressing cells without homozygous deletions were highly methylated at a CpG island of LRP1B, a sequence possessing promoter activity. Treatment with 5-aza-2′-deoxycytidine restored expression of LRP1B in those ESC lines. Histone acetylation status correlated directly with expression of LRP1B and inversely with the methylation status of the CpG island. Methylation of LRP1B was also detected in primary esophageal tumors. Restoration of LRP1B expression in ESC cells reduced colony formation. These results suggest that loss of LRP1B function in esophageal carcinogenesis most often occurs either by homozygous deletion or by transcriptional silencing through hypermethylation of its CpG island.
A control architecture with stabilizer for 3D stable dynamic walking of SHERPA biped robot on compliant ground

This paper deals with design and implementation of a control architecture for 3D dynamic walking with foot/ground compliant contact. This architecture includes a ZMP-based pattern generator, a computed torque controller based on the reduced order dynamics of the system, and a stabilizer to enhance the stability robustness of the control architecture. The effectiveness of the proposed control architecture is shown through numerical simulations.
Lesbian Mothers Living Well in the Context of Heterosexism and Discrimination: Resources, Strategies and Legislative Change

Although the heterosexism and discrimination encountered by lesbian women who are mothers can have negative practical, financial, social and psychological consequences, lesbian women and their families frequently thrive. Based on in-depth interviews from the Australian Conceiving the Family: Lesbian Mothers’ Decisions, Experiences and Well-being, and the Current Legal, Public Policy, and Discursive Context project, this article identifies the importance of legislative change in promoting the well-being of lesbian women who are mothers, and presents resources and strategies that some use to live well, resist heterosexism and discrimination and minimise its effects.
Continuous Glucose Monitoring in Patients with Type 1 Diabetes and Impaired Awareness of Hypoglycemia: Also Effective in Patients with Psychological Distress?

The aim of this study was to evaluate whether psychological distress modifies the effect of continuous glucose monitoring (CGM) in patients with type 1 diabetes (T1D) and impaired awareness of hypoglycemia. Fifty-two patients with T1D and impaired awareness of hypoglycemia participated in an earlier reported randomized crossover trial with two 16-week intervention periods comparing CGM with self-monitoring of blood glucose (SMBG). During the CGM phase, time spent in euglycemia (4-10 mmol/L), the primary outcome, was 9.6% higher compared with the SMBG phase (P < 0.0001). Psychological distress was operationalized as low emotional well-being (World Health Organization Well-being Index 5 [WHO-5] < 50), high diabetes-related distress (Problem Areas in Diabetes 5 [PAID-5] ≥ 8), and/or high fear of hypoglycemia (Hypoglycemia Fear Survey [HFS] Worry > mean HFS Worry score +1 standard deviation). Modifying effects were assessed by analyzing psychological distress score × intervention-interaction effects. Results showed that both the low emotional well-being group and normal emotional well-being group had equal glycemic outcomes during the CGM phase. High diabetes distress and elevated fear of hypoglycemia did not result in significant interaction effects for glycemic outcomes. This study demonstrated that CGM is equally effective in terms of glycemic improvements in high versus low distressed patients with T1D and impaired awareness of hypoglycemia.
Childhood Emotional Abuse and Risk for Hopelessness and Depressive Symptoms During Adolescence

ABSTRACT Previous research has indicated that childhood maltreatment is an important risk factor for the development of depressive disorders. However, few longitudinal studies have investigated the associations of emotional abuse with depressive symptoms. The present study investigated the association of emotional abuse with subsequent depressive symptoms and hopelessness among adolescent primary care patients. Measures of emotional maltreatment, hopelessness, and depressive symptoms were administered to a multisite sample of 92 adolescent primary-care patients. Hopelessness and depressive symptoms were assessed 3 months later. Reports of childhood emotional abuse were associated with elevated levels of hopelessness and depressive symptoms. Hopelessness significantly mediated the association of emotional abuse with depressive symptoms.
A Welfare Analysis of the Commonwealth Seniors Health Card

The Commonwealth Seniors Health Card (CSHC) is a key element of a suite of benefits for Australia's ‘self-funded retirees’. Its main component is a pharmaceutical concession, which is analysed as a form of public health insurance. The utility gain through risk-pooling is found to be negligible under conservative assumptions. The deadweight loss through moral hazard may be considerable. Finally, the CSHC may be seen as an inequitable transfer, because CSHC holders are a particularly wealthy population.
Expression of ORAI1, a Plasma Membrane Resident Subunit of the CRAC Channel, in Rodent and Non-rodent Species

We determined the expression of ORAI1 protein in rodent and non-rodent tissues using a monoclonal antibody directed against an extracellular loop of the protein. Previous reports using antibodies directed at the C-terminus of ORAI1 have not detected central nervous system (CNS) expression. Our results demonstrate broad tissue expression that includes the CNS using a unique monoclonal antibody specific to an extracellular loop of ORAI1. In addition, we present in situ hybridization (ISH) results using a probe within the middle of the mouse coding region showing CNS expression of Orai1 RNA. We contrast the patterns of rodent and human tissue expression and conclude that rodents have similar expression of ORAI1 in most tissue types when compared to primates, with an important exception being the male reproductive system, where human-specific expression is observed.
hTERT Is Highly Expressed in Ewing’s Sarcoma and Activated by EWS-ETS Oncoproteins

Although the fusion proteins EWS-ETS are uniquely associated with Ewing’s sarcoma and have been shown to have transformational properties, they are not the only determinants of oncogenesis. Therefore, before molecular-based therapy can be initiated, a better understanding of the molecular network specific to Ewing’s sarcoma is mandatory. Specimens from 31 patients with Ewing’s sarcoma were analyzed immunhistochemically. We found that human telomerase reverse transcriptase was expressed highly (78%) in Ewing’s sarcoma. The mean followup was 7 years (range, 1–21 years), and human telomerase reverse transcriptase expression was correlated with outcome. Because we did not find an association between expression pattern and survival, human telomerase reverse transcriptase may not serve as a tumor marker in Ewing’s sarcoma. However, the human telomerase reverse transcriptase promoter is shown to be activated by the fusion proteins. Therefore, transcriptional regulation via EWS-ETS may account for the high human telomerase reverse transcriptase expression in Ewing’s sarcoma.
Nonlinear phase field theory for fracture and twinning with analysis of simple shear

A phase field theory for coupled twinning and fracture in single crystal domains is developed. Distinct order parameters denote twinned and fractured domains, finite strains are addressed and elastic nonlinearity is included via a neo-Hookean strain energy potential. The governing equations and boundary conditions are derived; an incremental energy minimization approach is advocated for prediction of equilibrium microstructural morphologies under quasi-static loading protocols. Aspects of the theory are analysed in detail for a material element undergoing simple shear deformation. Exact analytical and/or one-dimensional numerical solutions are obtained in dimensionless form for stress states, stability criteria and order parameter profiles at localized fractures or twinning zones. For sufficient applied strain, the relative likelihood of localized twinning vs. localized fracture is found to depend only on the ratio of twin boundary surface energy to fracture surface energy. Predicted criteria for shear stress-driven fracture or twinning are often found to be in closer agreement with test data for several types of real crystals than those based on the concept of theoretical strength.