Miracle-dz/UniFAR-FTUs huggingface dataset:
Candida infections in patients with acute leukemia: Ineffectiveness of nystatin prophylaxis and relationship between oropharyngeal and systemic candidiasis

Ninety‐three hospitalizations of 70 patients, who underwent induction chemotherapy for acute leukemia to determine the effectiveness of oral nystatin in preventing oropharyngeal and systemic candidiasis were reviewed. Sixty‐two percent of patients who received prophylactic nystatin and 58% of patients who did not receive nystatin developed oropharyngeal candidiasis; 11% of patients who received prophylaxis and 21% of those who did not receive prophylaxis developed systemic candidiasis. The use of oral nystatin did not significantly diminish the risk of developing either type of Candida infection. Oropharyngeal candidiasis occurred more commonly in patients who had severe and prolonged leukopenia, had received more parenteral antibiotics, and had developed chemotherapy‐induced mucositis. Systemic candidiasis developed almost exclusively in patients who had prior oropharyngeal candidiasis. Guidelines for the empiric use of amphotericin B in these patients are provided.
Star-forming filaments in warm dark matter models

We performed a hydrodynamical cosmological simulation of the formation of a Milky Way-like galaxy in a warm dark matter (WDM) cosmology. Smooth and dense filaments, several comoving mega parsec long, form generically above z ∼ 2 in this model. Atomic line cooling allows gas in the centres of these filaments to cool to the base of the cooling function, resulting in a very striking pattern of extended Lyman-limit systems (LLSs). Observations of the correlation function of LLSs might hence provide useful limits on the nature of the dark matter. We argue that the self-shielding of filaments may lead to a thermal instability resulting in star formation. We implement a sub-grid model for this, and find that filaments rather than haloes dominate star formation until z ∼ 6, although this depends on how stars form in WDM. Reionization decreases the gas density in filaments, and the more usual star formation in haloes dominates below z ∼ 6, although star formation in filaments continues until z = 2. 15 per cent of the stars of the z = 0 galaxy formed in filaments. At higher redshift, these stars give galaxies a stringy appearance, which, if observed, might be a strong indication that the dark matter is warm.
Dynamic Software Updating in Java: Comparing Concepts and Resource Demands

Dynamic software updating (DSU) is an extremely useful feature to be used during software evolution. It can be used to reduce down-time costs, for security enhancements, profiling and testing new functionalities. There are many studies and solutions on dynamic software updating regarding diverse problems introduced by the topic, but there is a lack of research which compares various approaches concerning supported changes and demands on resources. In this paper, we are comparing currently available concepts for Java programming language that deal with dynamically applied changes and measuring the impact of those changes on computer resource demands.
International Affective Picture System (IAPS) in Chile: A cross- cultural adaptation and validation study El sistema internacional de imágenes afectivas (International Affective Picture System- IAPS) en Chile: Estudio de adaptación y validación transcultural

The International Affective Picture System (IAPS) (Lang, Ohman, & Vaitl, 1988) is a standardized set of photographs to induce emotions in the context of experimental investigations. The aim of this study was determine the psychometric behavior of the IAPS for the preparation of standards in the Chilean population and the subsequent validation of the instrument for its use in Chile. 208 university students participated (40% men) and had an affective experience induced using the presentation of visual stimuli extracted from sets 7 and 14 of the IAPS. In order to evaluate valence, arousal and dominance, the self-assessment manikin (SAM) was used, made up of pictographic scales for each dimension and a scale of continuous variation of emotional reactions. The IAPS showed psychometric behavior comparable to the original, with the same boomerang-shaped distribution of scores being found in the valence/arousal relationship. The IAPS is a reliable tool for inducing emotions in studies related to affectivity.
Multipath performance of handset adaptive array antennas in the vicinity of a human operator

This paper examines the performance of the adaptive array antennas used in digital handset systems by studying the minimum mean square error (MMSE) algorithm at 2 GHz. The array is comprised of multiple quarter-wavelength monopole antennas and planar inverted-F antennas (PIFAs). By calculating the spatial correlation between two different directions, we describe how significant enhancement in the capability of reducing interference signals can be achieved, even when the handset is being held in the vicinity of a human operator in the talking position. Secondly, a computer simulation has been carried out under a flat Rayleigh fading environment with multiple cochannel interference signals, in which the average bit error rate (BER) of the handset adaptive array antenna has been characterized for the coherent detection of phase-shift keyed (PSK) signals. The performance of the handset adaptive array is compared to that of an adaptive array comprising plural parallel half-wavelength dipole antennas that are one half-wavelength apart. The performance was also evaluated with regard to the distance between the handset and the human head for different unequal median values and fading correlations of the received signals. The study has revealed that the adaptive array under consideration has substantial potential, not only to reduce the relative power of interference signals, but also to combat multipath fading of the desired signal by using the spatial diversity function of the MMSE, even in close proximity to a human operator.
Palliative stenting of patent ductus arteriosus in older children and young adults With congenital cyanotic heart disease

To describe the indications, technique and results (early and short‐term follow‐up) of palliative patent ductus arteriosus (PDA) stenting in selected patients (2 years and older) with congenital cyanotic heart disease with reduced pulmonary blood flow who were not candidates for definitive surgery in the immediate future.
Multi-baseline spaceborne SAR imaging

This paper provides an overview of the future development of spaceborne SAR systems with multi-baseline imaging capability like polarimetric SAR interferometry (PolInSAR), tomography (TomoSAR) and holography (HoloSAR). The goal is to fill the multi-dimensional data space with additional information from acquisitions having different spatial or temporal baselines. Multi-baseline imaging opens the door for a new class of image products in spaceborne SAR. Well-known examples are across-track and along-track interferometry, which allow the measurement of surface topography, ground deformation, ocean currents as well as glacier movements. While across-track and along-track interferometry are well established techniques and have been widely used by current spaceborne SAR systems, PolInSAR, TomoSAR and HoloSAR are emerging techniques which are shaping the future development of spaceborne SAR. New mission concepts for multi-static SAR configurations with distributed and sparse arrays will pave the way for this development.
IMPROVING SEQUENTIAL FEATURE SELECTION METHODS' PERFORMANCE BY MEANS OF HYBRIDIZATION

In this paper we propose the general scheme of defining hybrid feature selection algorithms based on standard sequential search with the aim to improve feature selection performance, especially on high-dimensional or large-sample data. We show experimentally that “hybridization” has not only the potential to dramatically reduce FS search time, but in some cases also to actually improve classifier generalization, i.e., its classification performance on previously unknown data.
CUIS Team for NTCIR-13 AKG Task

This paper describes our approach for Actionable Knowledge Graph (AKG) task at NTCIR-13. Our ranking system scores each candidate property by combining semantic relevance to action and its document relevance in related entity text descriptions via a Dirichlet smoothing based language model. We employ supervised learning technique to improve performance by minimizing a simple position-sensitive loss function on our additional manually annotated training data from the dry run topics. Our best submission achieves NDCG@10 of 0.5753 and NDCG@20 of 0.7358 in the Actionable Knowledge Graph Generation (AKGG) subtask.
Improved dictionary learning algorithm with mappings for single image super-resolution

In this paper a coupled dictionary and mapping function learning algorithm is proposed for the task of single image super-resolution. The proposed algorithm consists of dictionary learning part and image reconstruction part. In the dictionary training stage we propose a coupled dictionary and mapping function learning using the K-singular value decomposition. Using this approach we try to enforce the similarity between the high resolution and low resolution sparse coefficients. The idea is to enforce the sparse coefficients of the low resolution image along with its dictionary to well reconstruct the high resolution image using high resolution dictionary. Here we propose to use a mapping function learning which can learn the linear mappings between two resolution levels. For the dictionary update stage the best low rank approximation of singular value decomposition is used. In the image reconstruction stage low resolution images are up-scaled to the high resolution by using the invariance of the sparse coefficients of two resolution levels. First sparse coefficients of low resolution are calculated using the low resolution dictionary and mappings and then they are converted to high resolution by using the high resolution dictionary and mappings. The proposed algorithm is compared with current leading super-resolution algorithms and provides state-of-the-art results.
Isolation in small populations of Wayampi Amerindians promotes endemicity and homogenisation of their faecal virome, but its distribution is not entirely random

ABSTRACT The isolated community of the Wayampi Amerindians has been extensively studied for the presence of beta lactamase‐producing enterobacteria and their gut microbiota. However, no information about their virome was available. This study tries to establish potential associations between the virome and diverse epidemiological data, through the metagenomic study of the faecal prophages and DNA viruses from 31 samples collected in 2010. Taxonomic assignments, composition, abundance and diversity analyses were obtained to characterise the virome and were compared between groups according to several demographic, environmental and medical data. Prophages outnumbered viruses. Composition and abundance of virome indicated relatively low variability. Diversity within samples showed no significant differences, regardless of the group comparison. Significant differences were observed in the beta diversity among samples according to hospitalisation and gender, but not by extended spectrum &bgr;‐lactamase carriage, antibiotic intake or possession of pets, although some viruses differed in some cases (e.g. immunodeficiency‐associated stool virus associated with antibiotic intake). The faecal virome of adult Wayampi is more homogeneous than that from western populations. Not a single factor analysed can explain alone the observed distribution of the virome, but differences by gender (fewer variability in females than males) may reflect differences in life habits and work.
Performance of non-orthogonal access with SIC in cellular downlink using proportional fair-based resource allocation

This paper investigates the system-level throughput of non-orthogonal access with a successive interference canceller (SIC) in the cellular downlink assuming proportional fair (PF)-based radio resource (bandwidth and transmission power) allocation. The purpose of this study is to examine the possibility of applying non-orthogonal access with a SIC to the systems beyond the 4G (thus IMT-Advanced) cellular system. Both the total and cell-edge average user throughput are important in a real system. PF-based scheduling is known to achieve a good tradeoff by maximizing the product of the average user throughput among users within a cell. In non-orthogonal access with a SIC, the scheduler allocates the same frequency to multiple users, which necessitates multiuser scheduling. To achieve a better tradeoff between the total and cell-edge average user throughput, we propose and compare three power allocation strategies among users, which are jointly implemented with multiuser scheduling. Extensive simulation results show that non-orthogonal access with a SIC with a moderate number of non-orthogonally multiplexed users significantly enhances the system-level throughput performance compared to orthogonal access, which is widely used in 3.9 and 4G mobile communication systems.
Assessment of a hand tremor based on analysis of the accelerometer signal

This paper presents the method developed for the assessment of a tremor based on analysis of the output signals from a 3-axis accelerometer placed on the index finger of the right hand. Firstly, the signal representing only acceleration caused by involuntary movement of the hand is determined. The tremor frequency is obtained as the dominant frequency of the PSD estimated for short segments of this signal by using the AR model. The presented method allows us to evaluate variability of tremor frequency in typical neurological tests. Streszczenie. W artykule opisano metodę opracowaną do oceny drżenia na podstawie analizy sygnałów wyjściowych z trójosiowego akcelerometru, który został umieszczony na palcu wskazującym prawej ręki. Najpierw wyznaczany jest sygnał reprezentujący tylko przyśpieszenie wywołane mimowolnym ruchem ręki. Częstotliwość drżenia jest określana jako dominująca częstotliwość PSD estymowanej dla krótkich segmentów tego sygnału na podstawie modelu AR. Prezentowana metoda umożliwia ocenę zmienności częstotliwości drżenia w typowych testach neurologicznych. (Ocena drżenia ręki na podstawie analizy sygnału z akcelerometru).
Solving permutation flow shop sequencing using ant colony optimization

This paper proposes an ant colony algorithm for permutation flow shop scheduling problem. The objective considered is to minimize makespan. Two priority rules are developed as heuristic information based on Johnson's Rule and total processing times. A local search is used for improving the constructed solutions. The proposed ant colony algorithm is tested on the benchmark problem set of Taillard. The obtained results are compared with the previous implementations of ant colony optimization which are available in the literature. Computational results show that the proposed algorithm performs better than other algorithms when the number of machines is less than ten.
Human herpesvirus 6 in multiple sclerosis and encephalitis

Human herpesvirus 6 (HHV-6) was identified from patients with HIV and lymphoproliferative diseases in 1986. It is a β-herpesvirus and is divided into two subgroups, variants A and B. HHV-6 variant B is the cause of exanthema subitum, while variant A has not yet definitely proven to cause any disease. HHV-6, especially variant A, is a highly neurotropic virus and has been associated with many diseases of the central nervous system (CNS) such as encephalitis and multiple sclerosis (MS). The present studies were aimed to elucidate the role of HHV-6 and its two variants in neurological infections. Special attention was given to study the possible role of HHV-6 in the pathogenesis of MS. We studied the expression of HHV-6 antigens using immunohistochemistry in brain autopsy samples from patients with MS and controls. HHV-6 antigen was identified in 70% of MS specimens whereas 30% of control specimens expressed HHV-6 antigen. In addition, HHV-6 antigen was associated with elevated expression of tissue plasminogen activator (tPA), an enzyme taking part in both neuronal development and degeneration. In order to study the role of HHV-6 in MS further, serum and cerebrospinal fluid (CSF) samples were collected from patients with MS and patients with other neurological diseases (OND) from patients visiting Helsinki University Central Hospital Neurological Outpatient Clinic during the years 2003 and 2004. A total of 27 patients with clinically definite MS (CDMS) and 19 patients with clinically possible MS (CPMS) and ageand gendermatched control patients with OND were included. In addition, we studied 53 children with suspected encephalitis. Samples were consecutively collected from the first and last quarter of the year 1995, from the sample series sent to the Department of Virology, University of Helsinki, for suspected viral encephalitis. We developed an immunofluorescence IgG-avidity assay for the detection of primary HHV6A and HHV-6B infection. For HHV-6B antibodies, no differences were observed between patients with MS and OND.
Spectral Efficiency Analysis for Downlink NOMA Aided Spatial Modulation With Finite Alphabet Inputs

As the conventional spatial modulation (SM) system lacks an efficient downlink multiple access scheme, this paper proposes a novel downlink nonorthogonal multiple access aided multiple-input multiple-output SM system with finite alphabet inputs. Mutual information (MI) is used to characterize the system's achievable spectral efficiency (SE). Because the MI lacks a closed-form formulation, in this paper we propose a computational-efficient lower bound to provide an approximation to the simulated MI. Besides, preprocessing is also designed at the receiver to mitigate the detrimental effect of channel correlation, which leads to striking a higher SE performance. Simulation results not only confirm the accuracy of our SE analysis, but also substantiate the superior SE performance achieved by the proposed preprocessing.
Modelling of Supply Air Jet from Diffusers of Four-way packaged Air-conditioner for CFD Analysis on Unsteady

Recently in Japan, many buildings introduce packaged air-conditioner (hereinafter, this is called “PAC”) as an air conditioning equipment. Most of the PACs can change the direction of supply air blown from the unit and the “Swinging Mode” can change airflow direction periodically as one of the airflow direction setting of PAC. Before constructing the building, appropriately predicting the indoor environment (e.g. temperature distribution or air velocity distribution and so on) is important for indoor environment design. CFD analysis is one of the simulation technique based on the fluid dynamics and have been used to predict the building environment. However, it will take long time to finish non-steady analysis while analysing swinging airflow with non-steady analysis in CFD, it may cause trouble in design situation. In order to shorten the analysis time and acquire more precise result, the purpose of this research is to establish a CFD model to possibly analyse the swinging airflow in non-steady condition, using dynamic Prescribed Velocity (P.V.) method. In this paper, the experiment to understand the characteristics of the airflow blown from the PAC was carried out. The results of airflow direction measured by an anemometer, airflow volume measured by a cardboard duct, airflow velocity near air supply opening measured by hotwire anemometer with X-type probe are obtained to establish the CFD model of analysing the swinging airflow with unsteady condition in this study.
Lateral Gene Transfer In Vitro in the Intracellular Pathogen Chlamydia trachomatis

ABSTRACT Genetic recombinants that resulted from lateral gene transfer (LGT) have been detected in sexually transmitted disease isolates of Chlamydia trachomatis, but a mechanism for LGT in C. trachomatis has not been described. We describe here a system that readily detects C. trachomatis LGT in vitro and that may facilitate discovery of its mechanisms. Host cells were simultaneously infected in the absence of antibiotics with an ofloxacin-resistant mutant and a second mutant that was resistant to lincomycin, trimethoprim, or rifampin. Selection for doubly resistant C. trachomatis isolates in the progeny detected apparent recombinant frequencies of 10−4 to 10−3, ∼104 times more frequent than doubly resistant spontaneous mutants in progeny from uniparental control infections. Polyclonal doubly resistant populations and clones isolated from them in the absence of antibiotics had the specific resistance-conferring mutations present in the parental mutants; absence of the corresponding normal nucleotides indicated that they had been replaced by homologous recombination. These results eliminate spontaneous mutation, between-strain complementation, and heterotypic resistance as general explanations of multiply resistant C. trachomatis that originated in mixed infections in our experiments and demonstrate genetic stability of the recombinants. The kind of LGT we observed might be useful for creating new strains for functional studies by creating new alleles or combinations of alleles of polymorphic loci and might also disseminate antibiotic resistance genes in vivo. The apparent absence of phages and conjugative plasmids in C. trachomatis suggests that the LGT may have occurred by means of natural DNA transformation. Therefore, the experimental system may have implications for genetically altering C. trachomatis by means of DNA transfer.
Gender differences in microsomal metabolic activation of hepatotoxic clivorine in rat.

The gender differences in the in vitro microsomal metabolic activation of hepatotoxic clivorine, a representative naturally occurring hepatotoxic otonecine type pyrrolizidine alkaloid, in Sprague-Dawley rats and their relation to the gender differences in susceptibility to clivorine intoxication were reported in the present study. Clivorine-induced liver damage in the male rat via metabolic activation to form the reactive pyrrolic ester followed by covalent binding to liver tissue constituents has been reported previously by our research group. The present study demonstrated, for the first time, that cytochromes p450 3A1 and 3A2, which are constitutively expressed in the male rat, might play a significant role in the metabolic activation of clivorine in the rat. Thus, in the male rat, the metabolic activation by liver microsomes to form the reactive pyrrolic ester was found as the only direct metabolic pathway of clivorine followed by subsequent formation of the toxic tissue-bound pyrroles leading to hepatotoxicity. In the case of the female rat, a less significant metabolic activation was observed, whereas the formations of two novel nonpyrrolic metabolites were determined as the predominant biotransformations. None of the four cDNA-expressed rat enzymes (cytochrome p450 2C12, 2E1, 3A1, 3A2) tested could catalyze the formation of these two new metabolites. Furthermore, the female rat (LD(50) = 114 +/- 9 mg/kg, i.p.) was found to be significantly less susceptible to clivorine intoxication than the male rat (LD(50) = 91 +/- 3 mg/kg, i.p.). Therefore, the results suggested that a significantly lower metabolic activation due to the lack of cytochrome p450 3A1 and p450 3A2 activities mainly accounted for the smaller susceptibility of the female rat to clivorine intoxication.