Miracle-dz/UniFAR-FTUs huggingface dataset:
Calcium hydroxylapatite gel (Radiesse) injection for the correction of postrhinoplasty contour deficiencies and asymmetries.

OBJECTIVES To describe our technique for the injection of calcium hydroxylapatite gel (Radiesse) to treat postrhinoplasty contour defects and to evaluate the agent's efficacy, duration of action, required dosage, complication rates, and patient satisfaction. Slight defects or asymmetries are not uncommon, even after well-executed rhinoplasty surgery in the most expert of hands. These contour deformities have been treated with filler agents in the past, but with mixed results. Calcium hydroxylapatite gel was recently introduced as a filler agent in facial plastic surgery, but its use has not yet been described in the correction of postrhinoplasty nasal contour defects. DESIGN A prospective before-and-after trial conducted in a private-practice facial cosmetic surgery office. Eligible patients had postrhinoplasty contour irregularities or asymmetry. Postrhinoplasty irregularities at the nasal dorsum or tip underwent subcutaneous injection with calcium hydroxylapatite. Main outcome measures included number of treatments, posttreatment injection pain score, required dose and complications, natural feel, patient satisfaction, and length of follow-up. Digital photographs were evaluated by blinded observers. RESULTS Thirteen patients were followed up prospectively for a mean of 2.5 months. The mean injection pain score was 1.9 (scale, 0-5); the mean dose, 0.19 mL. Patient satisfaction was good to excellent in 11 (85%) of 13 cases. Photographic improvement was seen in 15 (88%) of 17 treatment sites. CONCLUSIONS Calcium hydroxylapatite gel has been shown in this study to improve postrhinoplasty nasal symmetry and smooth the curves and lines that constitute the contour of the nose. The longevity of nasal augmentation by calcium hydroxylapatite remains unsettled; long-term safety is also unknown. Long-term studies of safety and efficacy are indicated.
Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.

Furin is a membrane‐associated endoprotease that efficiently cleaves precursor proteins on the C‐terminal side of the consensus sequence, Arg‐X‐Lys/Arg‐Arg1, and has been proposed to catalyze these reactions in both exocytic and endocytic compartments. To study its biosynthesis and routing, a furin construct (designated fur/f) containing the FLAG epitope tag inserted on the C‐terminal side of the enzyme's autoproteolytic maturation site was used. Introduction of the epitope tag had no effect on the expression, proteolytic maturation or activity of furin. Analysis of the localization of fur/f by immunofluorescence microscopy showed that its staining pattern largely overlapped with those of several Golgi‐associated markers. Treatment of cells with brefeldin A caused the fur/f distribution to collapse around the microtubule organizing center, indicating that furin is concentrated in the trans‐Golgi network (TGN). Immunoelectron microscopy showed unequivocally that furin resides in the TGN where it colocalized with TGN38. In agreement with its proposed activity in multiple compartments, antibody uptake studies showed that fur/f cycles between the cell surface and TGN. Furthermore, targeting to the TGN requires sequences in the cytoplasmic tail of the enzyme. Pulse‐chase and immunofluorescence analyses demonstrated that proregion removal occurs in the endoplasmic reticulum and that cleavage may be required for exist from this compartment. Finally, we show that proregion removal is necessary but not sufficient for enzyme activation.
An analysis of defence spending in Spain: A long‐run approach

This paper analyses the behaviour of Spanish public spending on defence for the period 1850–1995. Through the use of recent cointegration and unit root techniques, we demonstrate the existence of an equilibrium relationship between this variable and Spanish GDP during the years in question. Furthermore, the income elasticity of this relationship is shown to be equal to one. Finally, the detection and removal of a number of additive outliers, all of them related to different periods of military conflict, appears to be vital in obtaining these results.
Weekly rituximab consolidation following four cycles of R‐CHOP induction chemotherapy in very elderly patients with diffuse large B‐cell lymphoma: Consortium for improving survival of lymphoma study (CISL)

This study aimed to determine the objective response, toxicity, and clinical outcome of weekly rituximab consolidation after four cycles of R‐CHOP21 in very elderly patients with DLBCL. A prospective, multi‐institutional phase II trial was conducted on patients with previously untreated CD20+ DLBCL who were older than 70 yr. Patients were treated with four cycles of R‐CHOP21 followed by weekly consolidation with rituximab (375mg/m2, four times infusion) (NCT01181999). We also compared the clinical outcomes with an historical case‐matched control group treated conventionally with six cycles of R‐CHOP21. A total of 51 patients with newly diagnosed DLBCL were enrolled at 15 institutes between June 2010 and September 2013. The median age was 76 yr (range: 70–89). Forty‐one of the 51 patients completed the planned rituximab consolidation (R‐consolidation). The overall response rate was 78.4%, comprising 74.5% with a complete response and 3.9% with a partial response. After a median follow‐up of 20.3 months, 2‐yr progression‐free survival and overall survival were 63.9% and 68.7%, respectively. No serious toxicities were reported during rituximab consolidation. Weekly rituximab consolidation following four cycles of R‐CHOP21 resulted in an acceptable response with high tolerability and could be a good compromise between efficacy and safety for elderly patients with DLBCL.
The Impact of Mergers on Fares Structure: Evidence from European Low‐Cost Airlines

This paper examines mergers that lead to an almost immediate replacement of the target firm's business model in favor of that of the acquiring firm. We examine the post‐merger behavior of the two leading European dedicated low‐cost airlines, EasyJet and Ryanair, each acquiring another low‐cost airline, Go Fly and Buzz, respectively. We find that both takeovers had an immediate and sustained impact on both the pricing structures and the extent of intertemporal price schedules used on the acquired routes, with early booking fares noticeably reduced and only very late booking fares increased. The analysis suggests that the takeovers had a net beneficial effect for consumers, at least in price terms, as a consequence of the introduction of the acquiring firms' business models and associated yield management pricing systems.
An efficient approach for image-DSM co-registration for urban building extraction

Very high resolution (VHR) satellite images are the ideal geo-data for mapping urban areas. The co-registration of such images with elevation data is crucial for accurate 3D-supported building extraction and mapping applications. However, VHR satellite images are usually acquired off-nadir. Over urban areas, off-nadir images suffer from severe building lean caused by the images' perspective view. On the other hand, the elevations of digital surface models (DSM) are usually of orthographic projection. Such a difference makes pixel-by-pixel co-registration very challenging unless the DSM data are modified to be of Line-of-Sight projection (LoS-DSM). Therefore, this paper introduces a novel image-DSM co-registration method for building extraction. Based on generating disparity maps, the method constructs a perfectly co-registered LoS-DSM which is more efficiently than traditional algorithms. The root-mean-square-error of the developed LoS-DSM elevations was found to be less than 2 pixels relative to the traditional photogrammetric approach. Additionally, these elevations are of pixel-level co-registration accuracy.
A GATA Box in the GATA-1 Gene Hematopoietic Enhancer Is a Critical Element in the Network of GATA Factors and Sites That Regulate This Gene

ABSTRACT A region located at kbp −3.9 to −2.6 5′ to the first hematopoietic exon of the GATA-1 gene is necessary to recapitulate gene expression in both the primitive and definitive erythroid lineages. In transfection analyses, this region activated reporter gene expression from an artificial promoter in a position- and orientation-independent manner, indicating that the region functions as the GATA-1 gene hematopoietic enhancer (G1HE). However, when analyzed in transgenic embryos in vivo, G1HE activity was orientation dependent and also required the presence of the endogenousGATA-1 gene hematopoietic promoter. To define the boundaries of G1HE, a series of deletion constructs were prepared and tested in transfection and transgenic mice analyses. We show that G1HE contains a 149-bp core region which is critical for GATA-1gene expression in both primitive and definitive erythroid cells but that expression in megakaryocytes requires the core plus additional sequences from G1HE. This core region contains one GATA, one GAT, and two E boxes. Mutational analyses revealed that only the GATA box is critical for gene-regulatory activity. Importantly, G1HE was active in SCL−/− embryos. These results thus demonstrate the presence of a critical network of GATA factors and GATA binding sites that controls the expression of this gene.
Critical Analysis of the Binomial-Tree Approach to Convertible Bonds in the Framework of Tsiveriotis-Fernandes Model

In the present paper we show that the Binomial-tree approach for pricing, hedging, and risk assessment of Convertible bonds in the framework of the Tsiveriotis-Fernandes model has serious drawbacks. Key words: Convertible bonds, Binomial tree, Tsiveriotis-Fernandes model, Convertible bond pricing, Convertible bond Greeks, Convertible Arbitrage, Delta-hedging of Convertible bonds, Risk Assessment of Convertible bonds.
Successful implementation of CRM in luxury hotels: determinants and measurements

Purpose – Valid measurement scales for predicting the adoption of hoteliers’ customer‐centric orientation are in short supply. The present research develops and validates a new scale for a specific variable, i.e. Management Attitudes Towards Customer‐Centric Orientation (MATCCO). Furthermore, this research attempts to identify some broad determinants for a successful CRM system implementation and propose a research model depicting possible relationships among MATCCO, broad determinants and profit.Design/methodology/approach – A structured questionnaire has been developed in order to accomplish the research objectives. Data were collected from 86 Greek luxury hotels. Accepted methodology was used to construct the measure, factor analysis to determine the CRM key success factors (KSFs) and Pearson correlation, ANOVA and discriminant analysis to test the proposed model. Additionally, qualitative research was conducted in two Greek luxury hotels.Findings – A reliable and valid measure of MATCCO was constructe.
[Clinical analysis of the diagnosis of laryngeal tuberculosis].

OBJECTIVE To explore the clinical characteristic and diagnosis of modern laryngeal tuberculosis. METHOD A retrospective research among 33 patients of laryngeal tuberculosis, with definitive pathological result, had been done in the laryngeal-endoscope room in our department. RESULT The main symptoms of laryngeal tuberculosis are hoarseness and sore throat. Most of the patients did not accompany with pulmonary tuberculosis (TB) (63.6%). Few of them accompany with low-grade fever, night sweat and malnutrition (24.2%). There are three types in the laryngeal-endoscope vision: edema type, hyperplasia type and ulcer exudation type. The positive rates of PPD and phlegm bacteria examination are respectively 87.9% and 68.4%. There can be seen in the pathological slides the interstitial phagocytes and giant cell reaction. Granuloma consisting of epithelioid cell and Langhans' cells is coexistent with necrotic tissue. Cheese necrosis is the typical characteristic of the disease. CONCLUSION Severe local symptoms of laryngeal with slightly general symptoms are the clinical characteristics of modern laryngeal tuberculosis. The diagnosis of it depends mainly on the process of the disease, laryngeal-endoscope examination and PPD examination combined with phlegm bacteria examination. And the final diagnosis is based on the pathological biopsy and tubercular bacillus culturing.
THE EFFECTS OF INTRAUTERINE AND POSTNATAL UNDERNUTRITION ON NORMAL BRAIN DEVELOPMENT *

Postnatal undernutrition is the most common disease in the world affecting the health of children. It has been suggested that 50% of the inhabitants of the world in the 1960’s survived varying degrees of undernutrition in early life.2 Considering that we do not know what vitamin levels in the blood, liver, or brain of a newborn infant are optimal for normal development, nor how much of which trace metal is required by the growing infant, one might place the estimate considerably higher. In recent years, the mortality from undernutrition has declined, and the interest in associated problems, such as the influence of undernutrition on brain development, has increased. In 1965, de la Cruz and LaVeck stated, “There have been no adequate demonstrations of the effect of nutrition on learning ability and/or intelligence perhaps because there is no adequate method of measuring these qualities. ” Development of normal learning ability and intelligence is a multifactorial phenomenon related to such influences as genetics, intrauterine development, a nontraumatic birth and neonatal life, adequate stimulation as an infant and child, and a childhood uninterrupted by devastating disease or accidents. In 1972, I believe it can be stated that the effects of malnutrition will never be completely distinguishable from those of other factors influencing child development. Certainly, the environment that results in a malnourished child will also be more apt to alter intrauterine development, to reduce infant stimulation, or to result in a higher incidence of childhood disease and injury. In spite of this limitation, recent evidence from animal experimentation and human observation has suggested a strong association between infant malnutrition and altered brain development. Although it is unknown which parameters are most important in the human brain in relation to mental development, brain weight, cellularity, and myelin lipid formation are probably all important. These three factors, as well as studies concerning the influence of nutrition on intelligence, will be discussed initially in relation to postnatal undernutrition and then in relation to intrauterine undernutrition.
On the predictability limit of convection models of the Earth's mantle

Reconstructing convective flow in the Earth's mantle is a crucial issue for a diversity of disciplines, from seismology to sedimentology. The common and fundamental limitation of these reconstructions based on geodynamic modeling is the unknown initial conditions. Because of the chaotic nature of convection in the Earth's mantle, errors in initial conditions grow exponentially with time and limit forecasting and hindcasting abilities. In this work, we estimate for the first time the limit of predictability of Earth's mantle convection. Following the twin experiment method, we compute the Lyapunov time (i.e., e‐folding time) for state of the art 3‐D spherical convection models, varying rheology, and Rayleigh number. Our most Earth‐like and optimistic solution gives a Lyapunov time of 136 ± 13 Myr. Rough estimates of the uncertainties in best guessed initial conditions are around 5%, leading to a limit of predictability for mantle convection of 95 Myr. Our results suggest that error growth could produce unrealistic convective structures over time scales shorter than that of Pangea dispersal.
Human Resource Function Competencies in European Companies

This paper presents an overview of recent empirical research on human resource competencies in Europe. The data were collected in 2002 in the global Human Resource Competence Study, an initiative of the University of Michigan. The results suggest that personal credibility and HR delivery have a positive effect on the relative ranking of the HR function and its professionals. According to non-HRM respondents strategic contribution is the competency that will lead to financial competitiveness, while HR managers consider business knowledge to be crucial for added value of the HR function.
The Fed’s Policy Decisions and Implied Volatility

This paper examines how the Fed’s monetary policy decisions affect the implied volatility of the S&P 500 index. The results show that stock market uncertainty is significantly affected by the Fed’s policy decisions. In particular, we find that implied volatility generally decreases after FOMC meetings, while the relationship between target rate surprises and market uncertainty appears positive. However, our results also suggest that the apparent positive relationship between policy surprises and implied volatility is mostly driven by the volatility-reducing effects of negative surprises. We further document that implied volatility is affected by both scheduled and unscheduled policy actions, with the scheduled path surprises having the strongest impact on volatility. Finally, our findings indicate that the impact of monetary policy decisions on implied volatility is more pronounced during periods of expansive policy.
Learning from one another? International policy “emulation” and university–industry technology transfer

Cross-border "emulation" of economic and technology policies among industrial-economy governments has become common in recent years, and spans policies ranging from intellectual property rights to collaborative R&D. Recent initiatives by a number of industrial-economy governments suggest considerable interest in emulating the Bayh--Dole Act of 1980, a piece of legislation that is widely credited with stimulating significant growth in university--industry technology transfer and research collaboration in the United States. I examine the effects of Bayh--Dole on university--industry collaboration and technology transfer in the United States, emphasizing the lengthy history of both activities prior to 1980 and noting the extent to which these activities are rooted in the incentives created by the unusual scale and structure (by comparison with Western Europe or Japan) of the US higher education system. Efforts at "emulation" of the Bayh--Dole policy by other governments are likely to have modest success at best without greater attention to the underlying structural differences among the higher education systems of these nations. Copyright 2011 The Author 2011. Published by Oxford University Press on behalf of Associazione ICC. All rights reserved. , Oxford University Press.
What matters for growth in Europe? Institutions versus policies, quality versus instability

We study how the quality and instability of institutions and policies affect economic growth in 35 European countries. While stability entails valuable predictability, instability can reflect reforms that offer positive long-run consequences. We construct measures of quality and instability for a panel of countries for 1984–2009. Results suggest that the quality of policy is growth-promoting. Notably, this positive effect becomes larger the more unstable policies are. The findings suggest that for European countries, the benefits of policy flexibility – due to experimentation and learning or making rent seeking more difficult – dominate the costs of reduced predictability.
Crystal structures of MTH1187 and its yeast ortholog YBL001c

Xiao Tao, Reza Khayat, Dinesh Christendat, Alexei Savchenko, Xiaohui Xu, Sharon Goldsmith-Fischman, Barry Honig, Aled Edwards, Cheryl H. Arrowsmith, and Liang Tong* Department of Biological Sciences, Northeast Structural Genomics Consortium, Columbia University, New York, New York Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York
A Novel Harmonic Mitigation Converter for Variable Frequency Drives

In this paper, a novel autotransformer for 56-pulse AC-DC converter configuration is designed, modeled and simulated to feed vector controlled induction motor drive (VCIMD). The proposed autotransformer configuration consists of two paralleled 14-pulse AC-DC converters involving seven-phase shifted uncontrolled diode bridges with pulse doubling circuit. It improves power quality at AC mains and it meets IEEE-519 standard requirements at varying loads.
Analytical Modelling and Simulation of Single and Double Cone Pinholes for Real-Time In-Body Tracking of an HDR Brachytherapy Source

The choice of pinhole geometry is a critical factor in the performance of pinhole-collimator-based source tracking systems for brachytherapy QA. In this work, an analytical model describing the penetrative sensitivity of a single-cone pinhole collimator to photons emitted from a point source is derived. Using existing models for single-cone resolution and double-cone sensitivity and resolution, the theoretical sensitivity and resolution of the single-cone collimator are quantitatively compared with those of a double-cone collimator with an equivalent field of view. Monte Carlo simulations of the single and double-cone pinhole collimators using an accurate 3D model of a commercial high dose rate brachytherapy source are performed to evaluate the relative performance of each geometry for a novel real-time HDR brachytherapy QA system, HDR BrachyView. The theoretical penetrative sensitivity of the single-cone pinhole is shown to be higher than the double-cone pinhole, which is in agreement with the results from the Monte Carlo simulations. The wider pinhole response function of the single-cone collimator results in a larger total error between the projected center of the source and the estimated center of mass of the source projection for the singlecone collimator, with the greatest error (at the maximum FoV angle) being 0.54 mm for the double-cone pinhole and 1.37 mm for the single-cone at θ = 60°. The double-cone pinhole geometry is determined to be the most appropriate choice for the pinhole collimator in the HDR BrachyView probe.
Evaluating supply chain risk in Indian dairy industry: a case study

Risk and uncertainty have been found to be one of the indispensable parts of any manufacturing or service supply chain. No matter how strong is the supply chain, risk and uncertainty come into the picture by disrupting the operational flow. The situation further gets complicated, if the nature of the material the supply chain deals in, is perishable requiring conditioned transportation and storage. In this context, dairy-food supply chain is not a deviation. The empirical paper describes the risks and uncertainties of a dairy-food supply chain case in India. The study involves all the stakeholders in the system to identify the potential risks for the entire chain and strategies to address the same. The data, from 1,063 sample respondents, at different levels of the supply chain, are collected and assessed to detect major operational risks for the dairy industry. In total, 15 significant risks are identified throughout the supply chain of which eight are assessed to be critical ones. Strategies to minimise the high risks are also mentioned at different levels so as to increase the efficiency of the supply chain.