Miracle-dz/UniFAR-FTUs huggingface dataset:
Sexual partner characteristics and incident rectal Neisseria gonorrhoeae and Chlamydia trachomatis infections among gay men and other men who have sex with men (MSM): a prospective cohort in Abuja and Lagos, Nigeria

Background STIs including Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) potentiate HIV acquisition and transmission especially among gay men and other men who have sex with men (MSM). We investigated the influence of sexual network composition on incident rectal NG and/or CT infections among Nigerian MSM. Methods TRUST/RV368 is a cohort of MSM recruited using respondent-driven sampling at trusted community centres in Abuja and Lagos, Nigeria. MSM respondents (egos) provided STI risk factors and demographic information for up to five of their most recent sexual partners (alters) within their sexual networks. Egos were tested for HIV, NG and CT every 3 months. Log-binomial regression was used to assess associations between alter characteristics and incident NG and/or CT. Results Between March 2013 and October 2015, 492 MSM were longitudinally screened for STIs, of which 28.0% (n=138) were positive for incident rectal STI (61 NG only, 42 CT only and 35 NG and CT). Among egos, condom use was associated with STIs (half of the time vs never (adjusted risk ratio (aRR) 0.5; 95% CI 0.3 to 0.8), always/almost always vs never (aRR 0.7; 95% CI 0.5 to 1.0)). Incident STIs were associated with having a younger alter ≤19 versus 30 years (aRR 0.6; 95% CI 0.4 to 1.0), HIV infection (aRR 1.5; 95% CI 1.1 to 2.0) and engaging in sex under the influence of alcohol (aRR 1.4 95% CI 1.1 to 1.7) among regular alters and age ≤19 versus 30 years (aRR 0.3; 95% CI 0.2 to 0.6), HIV infection (aRR 1.4; 95% CI 1.1 to 1.8) and engaging in sex under the influence of alcohol (aRR 1.2 95% CI 1.0 to 1.4) among casual alters. Conclusions Given the centrality of sexual partner characteristics as risks for incident STIs among Nigerian MSM, there is a need to move beyond individual interventions and syndromic surveillance and get ‘out there’ in the STI management.
Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics*

Background: The enzymatic activities of the ATP10 family of mammalian P4-ATPases are unknown. Results: ATP10A catalyzes the flipping of NBD-PC and expression of ATP10A altered cell shape and inhibited cell adhesion and spreading. Conclusion: The enhanced PC flipping activity by ATP10A changes the lipid composition, which may cause a delay in cell spreading. Significance: This is the first evidence showing that PC flipping activity by P4-ATPase is associated with the plasma membrane dynamics. We showed previously that ATP11A and ATP11C have flippase activity toward aminophospholipids (phosphatidylserine (PS) and phosphatidylethanolamine (PE)) and ATP8B1 and that ATP8B2 have flippase activity toward phosphatidylcholine (PC) (Takatsu, H., Tanaka, G., Segawa, K., Suzuki, J., Nagata, S., Nakayama, K., and Shin, H. W. (2014) J. Biol. Chem. 289, 33543–33556). Here, we show that the localization of class 5 P4-ATPases to the plasma membrane (ATP10A and ATP10D) and late endosomes (ATP10B) requires an interaction with CDC50A. Moreover, exogenous expression of ATP10A, but not its ATPase-deficient mutant ATP10A(E203Q), dramatically increased PC flipping but not flipping of PS or PE. Depletion of CDC50A caused ATP10A to be retained at the endoplasmic reticulum instead of being delivered to the plasma membrane and abrogated the increased PC flipping activity observed by expression of ATP10A. These results demonstrate that ATP10A is delivered to the plasma membrane via its interaction with CDC50A and, specifically, flips PC at the plasma membrane. Importantly, expression of ATP10A, but not ATP10A(E203Q), dramatically altered the cell shape and decreased cell size. In addition, expression of ATP10A, but not ATP10A(E203Q), delayed cell adhesion and cell spreading onto the extracellular matrix. These results suggest that enhanced PC flipping activity due to exogenous ATP10A expression alters the lipid composition at the plasma membrane, which may in turn cause a delay in cell spreading and a change in cell morphology.
Segmentation of dermoscopy images based on fully convolutional neural network

Lesion segmentation is one of the crucial steps for computerized dermoscopy image analysis. To accurately extract lesion borders from dermoscopy images, a novel segmentation method based on fully convolutional neural network is proposed in this paper. The designed network contains a low-level trunk followed by two brunches (global brunch and local brunch). The low-level trunk is fine-tuned from VGG16 net. Two brunches with different receptive fields extract global and local features respectively. After the combination of the global and local features, the final segmentation results are obtained through pixel-wise softmax classification. Experiments are conducted on the challenge dataset ISBI 2016. The results demonstrate that our designed network is more adaptive to dermoscopy images, which obtain more accurate lesion borders with good robust than other state-of-the-art methods.
Region-based fully convolutional siamese networks for robust real-time visual tracking

Partial occlusions and deformations in visual object tracking are still very challenging. Existing Convolutional Neural Networks (CNNs) trackers either fail to handle these issues or can just run in low speed. In this paper, we present a real-time tracker which is robust to occlusions and deformations based on a Region-based, Fully Convolutional Siamese Network (R-FCSN). In the proposed R-FCSN, the information of regions is extracted separately by the proposition of positionsensitive score maps. Combining these score maps via adaptive weights leads to accurate location of the target on a new frame. The experiments illustrate that our method outperforms state-of-the-art approaches, and can handle the cases of object deformation and occlusion at about 51 FPS.
Adaptive Spatial Modulation for Wireless MIMO Transmission Systems

In this letter, an adaptive spatial modulation (ASM) transmission scheme is proposed to achieve better system performance under a fixed data rate. The proposed scheme is based on a developed modulation order selection criterion (MOSC), so as to minimize the conditioned pairwise error probability (PEP) for each channel realization. Furthermore, the special information-conveying mode of spatial modulation (SM) is utilized to reduce the complexity of the proposed algorithm. Simulation results show that the proposed adaptive SM scheme provides considerable system performance improvement compared to original SM system.
A numerical analysis of temperature elevation in a rabbit ocular with localized and uniformed exposure conditions at 60 GHz

A numerical dosimetry was performed for a rabbit ocular exposure by 60-GHz millimeter wave in this study. We compared calculated temperature elevation between localized exposure by a lens antenna and uniformed exposure by plane wave. Here, incident power density was normalized against spacial average of incident power over the surface of cornea according to the previous study. The peak incident power density of the lens antenna was 5.3 times higher than that of the plane wave. Therefore, the maximum temperature elevation by the lens antenna exposure was higher than that by the plane wave exposure. Thus, possibility was shown that threshold incident power density for ocular injury with the lens antenna exposure becomes lower than that with the plane wave exposure.
Big returns from small fibers: A review of polymer/carbon nanotube composites

This paper reviews recent studies conducted on carbon nanotube/polymer composites. Carbon nanotubes are promising new materials for blending with polymers with potential to obtain low-weight nanocomposites of extraordinary mechanical, electrical, thermal and multifunctional properties. The size scale, aspect ratio and properties of nanotubes provide advantages in a variety of applications, including electrostatically dissipative materials; advanced materials with combined stiffness, strength and impact for aerospace or sporting goods; composite mirrors; automotive parts that require electrostatic painting and automotive components with enhanced mechanical properties. The various processing methods for producing these nanocomposites are discussed, in particular melt mixing, solution processing and in-situ polymerization. Some key results are summarized, relating to the mechanical, electrical, thermal, optical and surface properties. Finally, the challenges for the future are discussed in terms of processing, characterization, nanotube availability, nanotube tailoring, and the mechanisms governing the behavior of these remarkable nanoscale composites. Polym. Compos. 25:630–645, 2004. © 2004 Society of Plastics Engineers.
Two subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis

While sporadic colorectal cancer (CRC) is classified into several molecular subtypes, stratification of familial colorectal tumors is yet to be well investigated. We previously established two groups of methylation markers through genome-wide DNA methylation analysis, which classified sporadic CRC and adenoma into three distinct subgroups: high-, intermediate-, and low-methylation epigenotypes. Here, we investigated familial adenomatous polyposis (FAP), through quantitative methylation analysis of 127 samples (16 cancers, 96 adenomas, and 15 benign mucosa from 14 patients with FAP) using six Group-1 and 14 Group-2 methylation markers, APC, BRAF, and KRAS mutation analysis, and CTNNB1 and TP53 immunohistochemical analysis. All the 14 patients presented with APC germline mutation. Three were from the same family and presented the same APC mutation. FAP tumors lacked BRAF-mutation(+) high-methylation epigenotype and were classified into two methylation epigenotypes. While 24 of 112 tumor samples showed intermediate-methylation epigenotype significantly correlating with KRAS-mutation(+) (P=3×10-4), 88 tumor samples showed low-methylation epigenotype correlating with the absence of KRAS- and BRAF-mutations. Similar to sporadic CRC, CTNNB1 was frequently activated at the adenoma stage, and TP53 mutation occurred during cancer development from adenoma. Whereas some patients showed a single epigenotype in all tumors throughout the colon, tumors with two distinct epigenotypes developed within a family with the same APC mutation or even within one patient. Methylation accumulation significantly correlated with proximal location and older age. These results indicate that there are at least two distinct molecular subtypes of FAP tumors, resembling sporadic CRC and independent from the APC germline mutation status.
Amplification of mRNAs from Single , Fixed , TUNEL-Positive Cells

her, J.J. McCormick, G.P. Taylor and R.J. Klebe. 1998. Overview of matrix metalloproteinase expression in transformed cells. Matrix Biol. 16:483-496. 3.Hill, H.Z. , C. Huselton, B. Pilas and G.J. Hill. 1987. Ability of melanins to protect against the radiolysis of thymine and thymidine. Pigment Cell Res. 1:81-86. 4.Kreader, C.A. 1996. Relief of amplification inhibition in PCR with bovine serum albumin or T4 gene 32 protein. Appl. Environ. Microbiol. 62:1102-1106. 5.Yoshii, T. , K. Ramura, T. Taniguchi and K.I. I. Akiyama. 1993. Water-soluble eumelanin as a PCR-inhibitor and a simple method for its removal. Jpn. J. Leg. Med. 47:323-329.
Chunking with Support Vector Machines

We apply Support Vector Machines (SVMs) to identify English base phrases (chunks). SVMs are known to achieve high generalization performance even with input data of high dimensional feature spaces. Furthermore, by the Kernel principle, SVMs can carry out training with smaller computational overhead independent of their dimensionality. We apply weighted voting of 8 SVMs-based systems trained with distinct chunk representations. Experimental results show that our approach achieves higher accuracy than previous approaches.
Inbreeding in Man.

Page 425, line 5, (see PDF) Page 430, line 5, for "4 genes in the parents" read "2 genes in the parent. " Page 430, line 9 from below, (see PDF) Page 435, line 4, for "0.07125( r-r 2)" read "0.07125( r-r 2) percent. " Page 438, line 6, (see PDF) Page 438, line 9 from below, for "2104" read "1580
Deformation Mechanism of Nanocrystalline Al-Fe Alloys by Analysis from Ab-Initio Calculations

Recently nanocrystalline Al-Fe alloys produced by a vapor quench method have been reported. These alloys are supersaturated solid solution and exhibit high strength with good ductility. It is postulated that the high strength of the Al-Fe alloys could be achieved by both the nano-grained structures and the solid solution strengthening. The contribution to the yield strength due to both the grain size strengthening and the solid solution strengthening were analyzed from the experimental data. Then the contribution to the yield strength due to the solid solution strengthening was estimated from the misfit strain calculated from the first principles in order to compare with analytical results estimated from the experimental data.
Physically Retrieving Cloud and Thermodynamic Parameters from Ultraspectral IR Measurements

Abstract A physical inversion scheme has been developed dealing with cloudy as well as cloud-free radiance observed with ultraspectral infrared sounders to simultaneously retrieve surface, atmospheric thermodynamic, and cloud microphysical parameters. A fast radiative transfer model, which applies to the clouded atmosphere, is used for atmospheric profile and cloud parameter retrieval. A one-dimensional (1D) variational multivariable inversion solution is used to improve an iterative background state defined by an eigenvector-regression retrieval. The solution is iterated in order to account for nonlinearity in the 1D variational solution. It is shown that relatively accurate temperature and moisture retrievals can be achieved below optically thin clouds. For optically thick clouds, accurate temperature and moisture profiles down to cloud-top level are obtained. For both optically thin and thick cloud situations, the cloud-top height can be retrieved with relatively high accuracy (i.e., error <1 km). Nati.
Sketch-based aerial image retrieval

Notwithstanding aerial image retrieval is an important and obligatory task, existing retrieval systems lose their efficiency when there is no available aerial image used as the exemplar query. In this paper, we take free-hand sketches into consideration and address the problem of sketch-based aerial image retrieval. This is an extremely challenging task due to the complex surface structures and huge variations of resolutions of aerial images, and few works have been devoted to it. For the first time to our knowledge, we propose a framework to bridge the gap between sketches and aerial images. Specifically, an aerial sketch-image dataset is first collected. Sketches and aerial images are augmented to varied levels of details and used to train a multi-scale deep hierarchical model. The fully-connected layers of the deep model are used as cross-domain features, and the similarity between aerial images and sketches is measured by the Euclidean distance. Experiments on several public aerial image datasets demonstrate the efficiency and superiority of the proposed method.
Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database

Objective Estimates of cancer risk and the effects of surveillance in Lynch syndrome have been subject to bias, partly through reliance on retrospective studies. We sought to establish more robust estimates in patients undergoing prospective cancer surveillance. Design We undertook a multicentre study of patients carrying Lynch syndrome-associated mutations affecting MLH1, MSH2, MSH6 or PMS2. Standardised information on surveillance, cancers and outcomes were collated in an Oracle relational database and analysed by age, sex and mutated gene. Results 1942 mutation carriers without previous cancer had follow-up including colonoscopic surveillance for 13 782 observation years. 314 patients developed cancer, mostly colorectal (n=151), endometrial (n=72) and ovarian (n=19). Cancers were detected from 25 years onwards in MLH1 and MSH2 mutation carriers, and from about 40 years in MSH6 and PMS2 carriers. Among first cancer detected in each patient the colorectal cancer cumulative incidences at 70 years by gene were 46%, 35%, 20% and 10% for MLH1, MSH2, MSH6 and PMS2 mutation carriers, respectively. The equivalent cumulative incidences for endometrial cancer were 34%, 51%, 49% and 24%; and for ovarian cancer 11%, 15%, 0% and 0%. Ten-year crude survival was 87% after any cancer, 91% if the first cancer was colorectal, 98% if endometrial and 89% if ovarian. Conclusions The four Lynch syndrome-associated genes had different penetrance and expression. Colorectal cancer occurred frequently despite colonoscopic surveillance but resulted in few deaths. Using our data, a website has been established at http://LScarisk.org enabling calculation of cumulative cancer risks as an aid to genetic counselling in Lynch syndrome.
Natural Killer Cells in Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation

Allogeneic hematopoietic cell transplantation (HCT) is a well-established therapeutic modality effective for a variety of hematological malignancies but, unfortunately, is associated with significant morbidity and mortality related to cancer relapse as well as to transplant-related complications including graft-versus-host-disease (GvHD). Natural killer (NK) cells are the first donor-derived lymphocyte subset to recover after HCT, and their crucial role in protection against cancer relapse and infections is well established. Conversely, the role played by NK cells in GvHD is still controversial. Early studies suggested a participation of NK cells in GvHD induction or exacerbation. Subsequently, experimental evidence obtained in mice as well observational studies performed in humans led to a model in which NK cells play a regulatory role in GvHD by repressing alloreactive T cell responses. This widely accepted model has been recently challenged by clinical evidence indicating that NK cells can in some cases promote GvHD. In this review, we summarize available knowledge about the role of NK cells in GVHD pathogenesis. We review studies uncovering cellular mechanisms through which NK cells interact with other immune cell subsets during GvHD leading to a model in which NK cells naturally suppress GvHD through their cytotoxic ability to inhibit T cell activation unless exogenous hyperactivation lead them to produce proinflammatory cytokines that can conversely sustain T cell-mediated GvHD induction.
Magnetic resonance colonography for the detection of inflammatory diseases of the large bowel: quantifying the inflammatory activity

Introduction: The purpose of this study was to assess the diagnostic accuracy of magnetic resonance colonography (MRC) for its ability to detect and quantify inflammatory bowel disease (IBD) affecting the colon. Endoscopically obtained histopathology specimens were used as the standard of reference. Materials and methods: Fifteen normal subjects and 23 patients with suspected IBD of the large bowel underwent MRC. Three dimensional T1 weighted data sets were collected following rectal administration of water prior to and 75 seconds after intravenous administration of paramagnetic contrast (gadolinium-BOPTA). The presence of inflammatory changes in patients was documented based on bowel wall contrast enhancement, bowel wall thickness, presence of perifocal lymph nodes, and loss of haustral folds. All four criteria were quantified relative to data obtained from normal subjects and summarised in a single score. This MRC based score was compared with histopathological data based on conventional endoscopic findings. Results: MRC correctly identified 68 of 73 segments found to reveal IBD changes by histopathology. All severely inflamed segments were correctly identified as such and there were no false positive findings. Based on the proposed composite score, MRC detected and characterised clinically relevant IBD of the large bowel with sensitivity and specificity values of 87% and 100%, respectively, for all investigated colonic segments. Conclusion: MRC may be considered a promising alternative to endoscopic biopsy in monitoring IBD activity or assessing therapeutic effectiveness.
P‐193: White‐Emitting Tandem Organic Light‐Emitting Devices with an Effective Connecting Architecture

We report efficient white‐emitting tandem organic light‐emitting devices using an effective connecting structure, which consists of a common electrode and hole‐injection/electron injection layers on two opposite sides. This connecting structure involves no sputtering or handling of reactive metals during device fabrication and can be prepared purely by thermal evaporation, thus simplifying device processing.
Fingertip proximity sensor with realtime visual-based calibration

Proximity and distance estimation sensors are broadly used in robotic hands to enhance the quality of grasping during grasp planning, grasp correction and in-hand manipulation. This paper presents a fiber optical proximity sensor that is integrated with a tactile sensing fingertip of a robotic hand of a mobile robot. The distance estimation of proximity sensors are typically influenced by the reflective properties of an object, such as color or surface roughness. With the approach proposed in this paper, the accuracy of the proximity sensor is enhanced using the information collected by the vision system of the robot. A camera is employed to obtain RGB values of the object to be grasped. Further on, the data obtained from the camera is used to obtain the correct calibration for the proximity sensor. Based on the experimental evidence, it is shown that our approach can be effectively used to reduce the distance estimation error.
The Impact of Education About Cervical Cancer and Human Papillomavirus on Women's Healthy Lifestyle Behaviors and Beliefs: Using the PRECEDE Educational Model

Background Early detection of cervical cancer improves the chances of successful treatment. Objective The aim of this study was to determine the effect of education about cervical cancer and human papillomavirus on the healthy lifestyle, behavior, and beliefs of Turkish women who were without cancer, using the PRECEDE education model. Methods This qualitative and quantitative study was conducted as a prospective, randomized, 2-group (intervention and control) trial at a community training center in north Turkey. A total of 156 Turkish women who were without cancer participated in this study. The semistructured interview form, the SF-36 Health Status Questionnaire, the Health Belief Model Scale for Cervical Cancer and Pap Smear Test, and the Healthy Lifestyle Behavior Scale II were used. Results The subdimension scores of the Health Belief Model Scale for Cervical Cancer and Pap Smear Test were found to be higher among women in the study group (cervical cancer seriousness, P = .001; health motivation, P = .001) as compared with the control group after the education program. The SF-36 Health Status Questionnaire domain scores for physical role limitations, mental role limitations, and general health perceptions increased in the study group after the intervention. Conclusion The posteducation health motivation of women in the study group was improved, the women's perceptions of obstacles to Papanicolaou testing decreased, and through increased knowledge and awareness, the rate of Papanicolaou testing increased. Implications for Practice Educational programs aimed at motivating women to increase their awareness of cervical cancer, preventing cervical cancer, and having Papanicolaou testing are necessary and beneficial in this sample.