Miracle-dz/UniFAR-FTUs huggingface dataset:
SCANPSC 100 F Embedded Boundary Scan Controller

The SCANPSC100F is designed to interface a generic parallel processor bus to a serial scan test bus. It is useful in improving scan throughput when applying serial vectors to system test circuitry and reduces the software overhead that is associated with applying serial patterns with a parallel processor. The ’PSC100F operates by serializing data from the parallel bus for shifting through the chain of 1149.1 compliant components (i.e., scan chain). Scan data returning from the scan chain is placed on the parallel port to be read by the host processor. Up to two scan chains can be directly controlled with the ’PSC100F via two independent TMS pins. Scan control is supplied with user specific patterns which makes the ’PSC100F protocol-independent. Overflow and underflow conditions are prevented by stopping the test clock. A 32-bit counter is used to program the number of TCK cycles required to complete a scan operation within the boundary scan chain or to complete a ’PSC100F Built-In Self Test (BIST) operation. SCANPSC100F device drivers and 1149.1 embedded test application code are available with National’s SCANEase software tools. Features n Compatible with IEEE Std. 1149.1 (JTAG) Test Access Port and Boundary Scan Architecture n Supported by National’s SCAN Ease (Embedded Application Software Enabler) Software n Uses generic, asynchronous processor interface; compatible with a wide range of processors and PCLK frequencies n Directly supports up to two 1149.1 scan chains n 16-bit Serial Signature Compaction (SSC) at the Test Data In (TDI) port n Automatically produces pseudo-random patterns at the Test Data Out (TDO) port n Fabricated on FACTTM 1.5 μm CMOS process n Supports 1149.1 test clock (TCK) frequencies up to 25 MHz n TTL-compatible inputs; full-swing CMOS outputs with 24 mA source/sink capability n Standard Microcircuit Drawing (SMD) 5962-9475001
Deletion of GPI 7 , a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol ( GPI ) core structure , affects GPI protein transport , remodeling , and cell wall

Citation for published version (APA): Benachour, A. , Sipos, G. , Flury, I. , Reggiori, F. , Canivenc-Gansel, E. , Vionnet, C. , . Benghezal, M. (1999). Deletion of GPI7, a yeast gene required for addition of a side chain to the glycosylphosphatidylinositol (GPI) core structure, affects GPI protein transport, remodeling, and cell wall integrity. The Journal of Biological Chemistry, 274(21), 15251-15261. DOI: 10.1074/jbc.274. 21.15251
Immunocytochemical study of an endometrial diffuse clear cell stromal sarcoma and other endometrial stromal sarcomas

Intermediate filament composition was studied in the following endometrial stromal tumors: low‐grade stromal sarcoma (endolymphatic stromal myosis), high‐grade stromal sarcoma with an associated adenocarcinoma (collision tumor), diffuse clear cell stromal sarcoma and a mesodermal mixed tumor (carcinosarcoma). The tumor cells of the stromal tumors as well as the mesenchymal elements of the mixed mesodermal tumor were decorated exclusively with antibodies to vimentin. Desmin was not demonstrated in these tumor cells. A biochemical study of the cytoskeletal filaments present in the low‐grade stromal sarcoma revealed, in addition to vimentin, β and γ actin as seen in normal endometrial stroma. Cytokeratins were only identified in epithelial components which were present in some of these tumors. Intermediate filament typing in these endometrial neoplasms contributes to the elucidation of histogenetic problems, may delineate mesenchymal from epithelial elements, may separate muscle from stromal lesions and in one instance helped to define a hitherto unreported diffuse clear cell stromal sarcoma.
Incidence and subtypes of early-onset dementia in a geographically defined general population

Objective: To estimate the incidence of early-onset dementia (EOD) and to compare the clinical characteristics of EOD vs late-onset dementia (LOD) in a geographically defined area. Methods: We used data from the Registry of Dementia of Girona (ReDeGi), an epidemiologic surveillance system of dementia. The ReDeGi is a standardized clinical registry of new dementia cases diagnosed in the 7 hospitals of the Health Region of Girona (Catalonia, Spain), which encompasses an area of 5,517 km2 and 690,207 inhabitants. EOD cases were defined as those patients residing in the target area at the time of diagnosis who were diagnosed with dementia with an age at onset of symptoms before 65 years. Results: The ReDeGi registered 2,083 patients between January 1, 2007, and December 31, 2009 (6.9% EOD). The incidence rate of EOD for the age range 30–64 was 13.4 cases per 100,000 person-years (95% confidence interval 11.3–15.8). Alzheimer disease was the most frequent cause of EOD (42.4%), followed by secondary dementia (18.1%), vascular dementia (13.8%), and frontotemporal dementia (9.7%). EOD cases at the time of diagnosis were less impaired on the Mini-Mental State Examination and had a greater score on the Blessed Dementia Rating Scale behavior subscale than LOD cases. The frequency of a personal history of depression was higher in EOD cases. Conclusions: The incidence of EOD was less than 6 cases per 100,000 person-years in the age group 30–49 years; in the age group 50–64 years, the incidence rate was 3-fold higher and doubled with each 5-year increase.
Modeling Variability and Uncertainty of Photovoltaic Generation: A Hidden State Spatial Statistical Approach

In this paper, we construct, fit, and validate a hidden Markov model for predicting variability and uncertainty in generation from distributed (PV) systems. The model is unique in that it: 1) predicts metrics that are directly related to operational reserves, 2) accounts for the effects of stochastic volatility and geographic autocorrelation, and 3) conditions on latent variables referred to as “volatility states. ” We fit and validate the model using 1-min resolution generation data from approximately 100 PV systems in the California Central Valley or the Los Angeles coastal area, and condition the volatility state of each system at each time on 15-min resolution generation data from nearby PV systems (which are available from over 6000 PV systems in our data set). We find that PV variability distributions are roughly Gaussian after conditioning on hidden states. We also propose a method for simulating hidden states that results in a very good upper bound for the probability of extreme events. Therefore, the model can be used as a tool for planning additional reserve capacity requirements to balance solar variability over large and small spatial areas.
Overcoming the Inadequacies or Limitations of Experimental Structures as Drug Targets by Using Computational Modeling Tools and Molecular Dynamics Simulations

X‐ray crystallography, NMR spectroscopy, and cryoelectron microscopy stand out as powerful tools that enable us to obtain atomic detail about biomolecules that can be potentially targeted by drugs. This knowledge is essential if virtual screening or structure‐based ligand‐design methods are going to be used in drug discovery. However, the macromolecule of interest is not always amenable to these types of experiment or, as is often the case, the conformation found experimentally cannot be used directly for docking studies because of significant changes between apo and bound forms. Furthermore, sometimes the desired insight into the binding mechanism cannot be gained because the structure of the ligand–receptor complex, not having been time‐resolved, represents the endpoint of the binding process and therefore retains little or no information about the intermediate stages that led to its creation. Molecular dynamics (MD) simulations are routinely applied these days to the study of biomolecular systems with the aims of sampling configuration space more efficiently and getting a better understanding of the factors that determine structural stability and relevant biophysical and biochemical processes such as protein folding, ligand binding, and enzymatic reactions. This field has matured significantly in recent years, and strategies have been devised (for example activated, steered, or targeted MD) that allow the calculated trajectories to be biased in attempts to properly shape a ligand binding pocket or simulate large‐scale motions involving one or more protein domains. On the other hand, low‐frequency motions can be simulated quite inexpensively by calculation of normal modes which allow the investigation of alternative receptor conformations. Selected examples in which these methods have been applied to several medicinal chemistry and in silico pharmacology endeavors are presented.
Description de milieu et analyse factorielle des correspondances multiples

L'analyse factorielle des correspondances multiples, traitant un tableau de variables de milieu qualitatives, est remarquablement adaptee a la recherche de variables de synthese (qualitatives ou quantitatives) dans la description du milieu considere. On illustre le fonctionnement de son interpretation sur un tableau de donnees recueillies en eau courante
Improved Clinical Efficacy with Wound Support Network Between Hospital and Home Care Service

OBJECTIVE:The aim of this study was to test the efficacy of a wound support network model between the primary home care service and the hospital. The impact on wound healing rate, cost benefit, and transfer of knowledge was investigated. INTERVENTION:The intervention group was exposed to a wound support network (n = 32), and the control group continued standard organization of treatment (n = 21). DESIGN:Nonrandomized controlled study; observations were made before (baseline) and after the implementation of the intervention (12 weeks). PATIENTS:Patients with chronic wounds (lasting >6 weeks and with wound area >1 cm2) in Oslo, Norway. MAIN OUTCOME MEASURES:Closure of the observation wound; wound size; total number of wounds; presence of eczema, edema, and pain; number of dressings per week; time spent per dressing; and number of control appointments at the hospital. The economic impact is calculated for the hospital and for the community of Oslo, Norway. MAIN RESULTS:The number of control appointments (t = 3.80, P < .001) was significantly decreased, and the number of completed treatments (P = .02) was significantly increased after 12 weeks in the intervention group compared with the control group. A significant improvement was evident in the intervention group in terms of eczema (P = .02), edema (P = .03), and closing of the observational wound (46.7% cases in the intervention group versus 25.0% in the control group). CONCLUSIONS:A wound support network between the primary home care service and the hospital is cost-effective, improves clinical efficacy of the home care services’ work, and reduces the need for consultations at the hospital.
Contrôle traductionnel des facteurs de restriction APOBEC3G/F par la protéine Vif du VIH-1

Le VIH-1, via sa proteine Vif, contrecarre l’activite des facteurs de restriction A3G et A3F de plusieurs manieres dont l’inhibition traductionnelle. Nous avons demontre que cette repression traductionnelle d’A3G par Vif est specifique de la region 5’UTR. De plus, une sequence uORF contenue dans cette region est essentielle pour la regulation de la traduction ainsi que pour la repression par Vif. Nous avons montre qu’A3G et A3F sont traduits par leaky-scanning et re-initiation et que la distance entre l’uORF et l’ORF principal est importante pour l’inhibition traductionnelle d’A3G et d’A3F. Ensuite, nous avons montre que ce mecanisme est tres conserve a travers differents sous-types de Vif et que les acides amines de Vif en position 39, 48 et 127 sont impliques dans cette repression. Enfin, nous avons observe que l’interaction entre Vif et A3G est necessaire pour la regulation traductionnelle. Des experiences de transfections des differents mutants d’A3G et d’A3F dans un systeme infectieux tel que le clone pNL4.3 sont envisagees. Celles-ci permettront de voir l’effet de l’uORF sur l’infectivite virale mais aussi sur l’assemblage, la maturation et la liberation des nouvelles particules virales.
Adaptive Fuzzy Control for Nonstrict-Feedback Systems With Input Saturation and Output Constraint

This paper presents an adaptive fuzzy control approach for a category of uncertain nonstrict-feedback systems with input saturation and output constraint. A variable separation approach is introduced to overcome the difficulty arising from the nonstrict-feedback structure. The problem of input saturation is solved by introducing an auxiliary design system, and output constraint is handled by utilizing a barrier Lyapunov function. Combing fuzzy logic system with the adaptive backstepping technique, the semi-global boundedness of all variables in the closed-loop systems is guaranteed, and the tracking error is driven to the origin with a small neighborhood. The stability of the closed-loop systems is proved, and the simulation results reveal the effectiveness of the proposed approach.
Fuzzy logic control of a planetary gear type walking machine leg

In this paper, the development of a fuzzy logic control algorithm for walking machine leg control is presented. The planetary gear leg is designed for a quadruped which can walk and trot under the following design criteria: high efficiency, compact size and high payload/weight ratio. The inverse kinematics and dynamics of this leg are first analysed. A fuzzy logic control algorithm is then developed and implemented to control this prototype leg. The controller controls the leg using position control when the foot is in the air and force control when the foot is on the ground. This fuzzy logic control algorithm is evaluated in both simulation and experiments. A comparison of the proposed control algorithm with the conventional impedance control is given. Results show that the fuzzy logic controller is effective in controlling the leg machine.
Effect of Oxadiazolyl 3(2H)-Pyridazinone on the Larval Growth and Digestive Physiology of the Armyworm, Pseudaletia separata

Abstract The effect of oxadiazolyl 3(2H)-pyridazinone (ODP), a new insect growth regulator, on growth of larvae of the armyworm, Pseudaletia separata Walker (Lepidoptera: Noctuidae) was evaluated in comparison to the insecticide, toosendanin, a tetranortriterpenoid extracted from the bark of Melia toosendan that has multiple effects on insects. The digestive physiological properties of these compounds on insects were investigated by feeding them maize leaves dipped in these compounds. The results showed that ODP inhibited the growth of P. separata significantly, causing a slowed development and a prolonged larval period, smaller body size and sluggish behavior, delayed pupation and a reduced eclosion rate of pupae and adults. Moreover, ODP strongly inhibited the activities of weak alkaline trypsine-like enzyme, chymotrypsin-like enzyme and alpha amylase in the midguts of fifth instar P. separata larvae, in vivo, and inhibited the activity of alpha amylase, in vitro. These data suggest that ODP has severe consequences on the larval carbohydrate assimilation and/or nutrient intake and thereby causes inhibition of larval growth. The regulatory action of ODP on larval growth development was similar to that of toosendanin; both could be used to decrease the growth of insect populations.
Antibody to gp39, the ligand for CD40 significantly inhibits the humoral response from Graves' thyroid tissues xenografted into severe combined immunodeficient (SCID) mice.

Experimental evidence suggests that interference with gp39-CD40 interactions may have therapeutic potential in prevention of certain autoimmune disorders (i.e., collagen-induced rheumatoid arthritis). The binding between CD40 expressed on mature B cells and CD40 ligand (CD40L, gp39) transiently expressed on activated T helper cells (Th) further stabilizes the interactions (between Th and B cells) and co-ordinates the responses of the interacting cells during antigen presentation, and is essential for thymus-dependent humoral immunity. Graves' disease is the most common form of hyperthyroidism, in which hyperactivity of the thyroid gland is due to an autoantibody directed against the thyrotropin receptor (TSHR). The main objective of our study was to determine the role of interactions between gp39 and CD40 in "an established" human Graves' disease (GD). Severe combined immunodeficient (SCID) mouse served as a vehicle for human Graves' thyroid tissue. This experimental setting allows us to study, observe, and immunomodulate human autoimmune tissue in so called in vivo condition. We studied the effects of ip administration of anti-gp39 mAb on humoral response, thyroid function tests, expression of adhesion molecules, and HLA-DR on human thyrocytes and histopathological changes from human GD thyroid tissue xenografts. GD thyroid tissue from 4 patients was xenografted into 20 SCID mice (0.8 g/mouse). Human immunoglobulin G (IgG) levels became detectable in SCID mice 1 week after xenograftment. Ten SCID mice were sequentially administered anti-gp39 mAb (250 micrograms/mouse/ dose) ip every 4 days until the end of the experiment. Ten control animals were injected with vehicle (PBS) in similar fashion. Blood samples were taken every 2 weeks from the tail veins for measurement of the humoral response [human IgG, thyroid-stimulating antibody (TSAb), antithyroperoxidase (anti-TPO), and antithyroglobulin (anti-Tg), Abs], and thyroid function tests. After 8 weeks, animals were sacrificed and thyroid tissue was examined histologically. The humoral response from the intrathyroidal lymphocytes was measured and the tissue morphology of GD was preserved during the 8-week period in phosphate-buffered saline (PBS)-treated SCID mice xenografted with GD xenografts. However, administration of anti-gp39 mAb completely blocked or significantly decreased the humoral response in all treated animals. On the other hand, no significant histological changes were associated with the administration of anti-gp39 mAb. The degree of lymphocytic infiltration in thyroid tissue xenografts was comparable in both groups. Serum thyroxine values were normal in both groups. In spite of a profound immunosuppressive effect on the humoral response by directly blocking CD40-gp39 interactions in vivo, this did not result in complete deletion of the responding Th in the thyroid specimens.
Fitness landscapes support the dominance theory of post-zygotic isolation in the mussels Mytilus edulis and M. galloprovincialis

We studied the genetic basis of post-zygotic isolation in the marine mussels Mytilus edulis and Mytilus galloprovincialis. Evidence was obtained for a high number of recessive Dobzhansky–Muller substitutions in the genome of these two mussel taxa. We analysed the segregation of unlinked diagnostic markers in the progeny of two backcrosses and an F2 cross, 36 h and 200 days after fertilization. Directional selection favouring M. galloprovincialis genotypes was observed in both kinds of cross. In the F2, epistatic interactions between each pair of chromosome fragments mapped by the markers were identified in addition. Our results imply that homozygous–homozygous interactions are required for breakdown of coadaptation, in accordance with the dominance theory of post-zygotic isolation. Endogenous post-zygotic selection distributed over many loci throughout the genome provides the missing factor explaining the astonishing persistence and strength of barriers to neutral introgression in such a dispersive taxon as Mytilus.
Chimeric NUP 98 – NSD 1 transcripts from the cryptic t ( 5 ; 11 ) ( q 35 . 2 ; p 15 . 4 ) in adult de novo acute myeloid leukemia

The t(5;11)(q35;p15.4) is a clinically significant marker of poor prognosis in acute myeloid leukemia (AML), which is difficult to detect due to sub-telomeric localization of the breakpoints. To facilitate the detection of this rearrangement, we studied NUP98–NSD1 transcript variants in patients with the t(5;11) using paired-end RNA sequencing and standard molecular biology techniques. We discovered three NUP98–NSD1 transcripts with two fusion junctions (NUP98 exon 1112/NSD1 exon 6), alternative 50 donor site in NUP98 exon 7, and NSD1 exon 7 skipping. Two of the transcripts were in-frame and occurred in all t(5;11) samples (N1⁄4 5). The exonic splicing events were present in all samples (N1⁄4 23) regardless of the NUP98–NSD1 suggesting that these novel splice events are unassociated with t(5;11). In conclusion, we provide evidence of two different NUP98–NSD1 fusion transcripts in adult AML, which result in functional proteins and represent suitable molecular entities for monitoring t(5;11) AML patients. ARTICLE HISTORY Received 11 April 2017 Revised 21 June 2017 Accepted 14 July 2017
Small Linear PM Oscillatory Motor: Magnetic Circuit Modeling Corrected by Axisymmetric 2-D FEM and Experimental Characterization

Linear permanent-magnet (PM) actuators with short strokes represent an excellent alternative to pneumatic or hydraulic actuators in different fields of application, whenever fast response, flexibility, high reliability, and safety are required. The purpose of this paper is to present a new hybrid model and a testing sequence to rather completely characterize a small PM oscillatory motor for compressor-like applications. The hybrid model is composed of an iterative nonlinear magnetic circuit method which is corrected by an axisymmetric (2-D) finite-element method (FEM) model. The benefit that this hybrid model has is its low computation time when compared with similar analysis using 3-D FEM. This characteristic is very significant for industrial usage.
Does optical coherence tomography identify arterial healing after stenting? An in vivo comparison with histology, in a rabbit carotid model

Objective: To verify whether optical coherence tomography (OCT) can accurately monitor the occurrence of arterial healing after stenting. Setting: Delayed stent endothelialisation may predispose to stent thrombosis. OCT is a high-resolution intravascular imaging technique that accurately identifies stent struts and arterial tissues. Design and interventions: Eight New Zealand white rabbits underwent the implantation of single bare metal stents (diameter 2–2.5 mm, length 8–13 mm) in the right common carotid artery through the external carotid artery. After a median of 11 days (range 2–28), the stented arteries were visualised by OCT, with images acquired at a pull-back speed of 0.5 mm/sec. The rabbits were then euthanised, vessels were formalin-fixed and finally processed for histopathology. Results: We analysed 32 cross-sections from eight stented carotid arteries, for a total of 384 stent struts. OCT detected all of the stent struts in 30 of 32 cross-sections (93.7%), and correctly identified the presence/absence of tissue for every strut. Histological and OCT measurements of mean neointima thickness (0.135 (SD 0.079) mm and 0.145 (SD 0.085) mm, respectively, p = NS) were similar and closely related (r = 0.85, p<0.001). Neointima area progressively increased with longer time intervals from stent deployment to sacrifice; histological and OCT measurements were similar for each time interval. The intra-observer and interobserver reproducibility of OCT neointima measurements were excellent (R2 = 0.90 and 0.88, respectively). Conclusions: OCT is a promising means for monitoring stent strut coverage and vessel wall healing in vivo, the relevance of which will become even more significant with the increasing use of drug-eluting stents.