Miracle-dz/UniFAR-FTUs huggingface dataset:
PARAMETER STUDY OF STABLE WALKING GAITS FOR NAO HUMANOID ROBOT

It is a challenge to any researcher to maintain the stability of the robot while in the walking motion . This paper proposes for parameter study of a walking pattern method which i s inspired by the Dip Goswami (2009). The walking pis generated based on three points. These points are located at ankle left and right and one at the hip of the NAO humano id robot. By using these points the walking gaits are generated to use as a referen ce point while walking motion. Then, an inverse kin ematics with geometric solution of a ten degree-of-freedom humanoid robot is formul ated from hip until the ankle joint. By sampling pe riod of time with ten this reference point is used to find the joint angle of each link. The NAO humanoid robot is built in with force resistive sensor (FSR) located under both feet are used to determine the w alking stability by using force distributer concept . The zero moment point of the robot is calculated on the normalized value between FSR reading from right leg and left leg. The resul t shown based on the real time simulation environment by using Webots Robotic Soft ware. A simulation result shows that a NAO humanoid robot successfully walks in stable condition by following five different wal king parameter setting. The humanoid robot is stabl e if and only if the normalized value of the ZMP is between 1 and -1.
Fast Generation of Virtual X-ray Images from Deformable Tetrahedral Meshes

We propose a novel GPU-based approach to render virtual X-ray projections of deformable tetrahedral meshes. These meshes represent the shape and the internal density distribution of a particular anatomical structure and are derived from statistical shape and intensity models (SSIMs). We apply our method to improve the geometric reconstruction of 3D anatomy (e.g.\ pelvic bone) from 2D X-ray images. For that purpose, shape and density of a tetrahedral mesh are varied and virtual X-ray projections are generated within an optimization process until the similarity between the computed virtual X-ray and the respective anatomy depicted in a given clinical X-ray is maximized. The OpenGL implementation presented in this work deforms and projects tetrahedral meshes of high resolution (200.000+ tetrahedra) at interactive rates. It generates virtual X-rays that accurately depict the density distribution of an anatomy of interest. Compared to existing methods that accumulate X-ray attenuation in deformable meshes, our novel approach significantly boosts the deformation/projection performance. The proposed projection algorithm scales better with respect to mesh resolution and complexity of the density distribution, and the combined deformation and projection on the GPU scales better with respect to the number of deformation parameters. The gain in performance allows for a larger number of cycles in the optimization process. Consequently, it reduces the risk of being stuck in a local optimum. We believe that our approach contributes in orthopedic surgery, where 3D anatomy information needs to be extracted from 2D X-rays to support surgeons in better planning joint replacements.
A nonlinear sliding surface to improve performance of a discrete-time input-delay system

A sliding mode controller is proposed for an uncertain input-delay system to enhance performance. A nonlinear sliding surface is proposed to achieve better transient response for general uncertain discrete SISO linear systems with input delay. Both matched and unmatched perturbations are considered and ultimate boundedness of motion is proved. The step tracking problem is analysed. The proposed surface increases the damping ratio of the transformed system (delay free) as the output moves nearer to the setpoint. To simplify the surface design, a linear matrix inequality based tuning procedure is proposed. The control law is designed based on an equivalent control approach which guarantees one step reaching. The scheme is able to achieve low overshoot and low settling time simultaneously which is not possible with a linear sliding surface. Simulation results verify the effectiveness of the proposed nonlinear surface over different linear surfaces.
Ingestão de Alimentos Fluidos e Risco de Excesso de Peso em Crianças

A obesidade infantil atinge dimensoes epidemicas. Entre os factores alimentares consideradossusceptiveis de aumentar o risco de obesidade, inclui-se o consumo de bebidasacucaradas e de energia sob a forma liquida.Objectivo: Avaliar a associacao entre a ingestao de alimentos fluidos e o excesso de pesoem criancas.Material e metodos: A amostra final do estudo inclui 1675 criancas dos cinco aos 10 deidade (de 35 escolas do Porto), apos eliminar os questionarios incorrectamente preenchidosou com valores implausiveis de ingestao energetica. Depois de recebermos as declaracoesde consentimento informado preenchidas e assinadas pelos respectivos pais/encarregados de educacao, avaliamos o peso e a altura de acordo com os procedimentosinternacionalmente recomendados, e calculamos o indice de massa corporal; definiu-seexcesso de peso segundo os criterios da International Obesity Task Force. Os pais/encarregados de educacao das criancas preencheram um inquerito com dados relativos afamilia, actividade fisica e ingestao alimentar (questionario de frequencia de consumoalimentar que incluia a avaliacao da ingestao de leite, sopa de horticolas, colas, ice-tea eoutros refrigerantes/sumos/nectares) da crianca. Foram utilizados modelos de regressaologistica, por sexo, de forma a estimar a magnitude da associacao entre o consumo defluidos e o estado ponderal das criancas, com ajuste para confundidores.Resultados: Destacam-se como principais resultados, a elevada prevalencia de excessode peso e obesidade (36,6%, para raparigas, e 38,8% para rapazes). Nas raparigas, aocorrencia de excesso de peso e obesidade foi significativamente maior nas que tinhambaixo consumo de sopa (igual ou inferior a mediana) (OR = 0,609, IC 95% 0,44-0,83, p =0,002), relativamente as que tinham ingestao elevada (superior a mediana), mesmo aposajuste para confundidores (OR = 0,68, IC 95% 0,48-0,96, p = 0,030). Nao se encontraramassociacoes significativas entre a ingestao de bebidas acucaradas ou leite e a ocorrenciade excesso de peso nas criancas de ambos os sexos.Conclusao: Dos alimentos fluidos avaliados apenas o consumo de sopa protegeu significativamenteas raparigas da ocorrencia de excesso de peso, independentemente deoutras caracteristicas.
Autonomous fault tolerant multi-robot coordination for object transportation based on Artificial Immune System

An efficient coordination strategy is required in order to realize an efficient and autonomous multi-robot cooperative system. This paper presents an approach for coordination among robots prior to cooperative object transportation. This paper does not address the coordination that is required during cooperation, which has been researched by others. In the present paper, fault tolerant coordination is achieved using methodology of artificial immune system. The approach developed here is based on binding affinity between an antibody and an antigen, and the structure of antibody in a human immune system. The developed methodology is verified through physical experiments.
Datenqualität bei Online-Fragebögen sicherstellen

Über Online-Fragebögen können Daten zur User Experience eines Produkts mit geringem Aufwand erhoben werden. Allerdings hat man hier in Bezug auf die Qualität der Daten wenig Kontrollmöglichkeiten. Insbesondere wenn die Teilnehmer mit einer Belohnung zur Teilnahme an einer Befragung motiviert werden, besteht die Gefahr, dass viele Fragebögen nicht sorgfältig ausgefüllt sind. Dies kann die Ergebnisse und die daraus abgeleiteten Interpretationen zur Produktqualität verfälschen. Wir beschreiben zwei Strategien, um diesem Problem zu begegnen. Die erste Strategie nutzt die Skalenstruktur des Fragebogens, um inkonsistente Antworten zu identifizieren. Treten in den Antworten einer Person zu viele Inkonsistenzen auf, ist dies ein Indikator für mehr oder weniger zufälliges Antwortverhalten. Die zweite Strategie vergleicht die Antwortzeiten einer Person für die einzelnen Items mit den aus einer kognitiven Modellierung geschätzten Zeiten. Hier sind viele zu schnelle Antworten ein Indikator für eine nicht sorgfältige Beantwortung.
Mirtazapine Induced Akathisia: Understanding a Complex Mechanism

1. Vieta E, Valenti M. Pharmacological management of bipolar depression: Acute treatment, maintenance, and prophylaxis. CNS Drugs 2013;27:515-29. 2. Citrome L. Treatment of bipolar depression: Making sensible decisions. CNS Spectr 2014;19 Suppl 1:1-12. 3. Goldberg JF, Burdick KE, Endick CJ. Preliminary randomized, double-blind, placebo-controlled trial of pramipexole added to mood stabilizers for treatment-resistant bipolar depression. Am J Psychiatry 2004;161:564-6. 4. Mah L, Zarate CA Jr, Nugent AC, Singh JB, Manji HK, Drevets WC. Neural mechanisms of antidepressant efficacy of the dopamine receptor agonist pramipexole in treatment of bipolar depression. Int J Neuropsychopharmacol Access this article online
Food Processing by High Hydrostatic Pressure

The use of high hydrostatic pressures (HHP) for food processing is finding increased application within the food industry. One of the advantages of this technology is that because it does not use heat, sensory, and nutritional attributes of the product remain virtually unaffected, thus yielding products with better quality than those processed traditional methods. HHP have the ability to inactivate microorganisms as well as enzymes responsible for shortening the life of a product. In addition to lengthening the shelf-life of food products, HHP can modify functional properties of components such as proteins, which in turn can lead to the development of new products. Equipment for large-scale production of HHP processed products are commercially available nowadays. Guacamole, sliced ham, oysters, and fruit juices are some of the products currently available on the market. HHP technology is one of the most promising nonthermal processes.
Shock Reliability of Vacuum-Packaged Piezoelectric Vibration Harvester for Automotive Application

This paper reports for the first time the shock reliability of vacuum-packaged piezoelectric vibration harvesters for automotive application. Experimental study on >80 devices shows that the failure is induced by the impact between seismic mass and glass package. The statistical results obtained for various types of harvesters have shown a trend of higher shock reliability for a higher resonance frequency. The influence of beam thickness on the shock reliability is then discussed. The trade-off between the power output and shock reliability is elaborated. To further improve the reliability to the level of automotive application, the idea of stepped cavity is discussed and implemented. The experimental results confirmed a significantly enhanced reliability increased by ~50%, up to maximum 2000 g, for the same type of device under shock excitations.
Up‐regulation of the T cell quiescence factor KLF2 in a leukaemic T‐cell line after expression of the inositol 5′‐phosphatase SHIP‐1

Inositol 5′‐phosphatase SHIP‐1 (SHIP) is a negative regulator of signal transduction in haematopoietic cells. SHIP inactivation may be involved in the pathogenesis of leukaemia. An inducible expression system was combined with microarray analysis to identify target genes regulated by SHIP in the human T‐cell leukaemia cell line Jurkat. One gene identified was Krüppel‐like factor 2 (KLF2), which was up‐regulated two to threefold at the RNA and protein level after the induced expression of SHIP. KLF2, a negative regulator of T cell proliferation, has been implicated in T cell quiescence. KLF2 or SHIP expression in Jurkat cells caused 45% or 60% reduction of proliferation, respectively. SHIP can up‐regulate KLF2 expression, implicating KLF2 in the SHIP‐mediated growth inhibition of a human leukaemic T‐cell line.
Architectural, Service, and Performance Modeling for an IMS-MBMS-Based Application

This paper describes iRide (intelligent ride), an IP Multimedia Subsystem (IMS), Multimedia Broadcast Multicast Service (MBMS), and wireless sensor network (WSN) joint application. The core contributions of iRide are: IMS and WSN architectural integration on joint data processing and signaling levels, application logic for increased road safety, and network dimensioning for scalability and performance analysis. The iRide architecture is built and prototyped using IMS standard SIP (Session Initiation Protocol) and DIAMETER signaling together with 3GPP MBMS for more efficient service handling. OPNET simulations are used to conduct network dimensioning and performance analysis. Resource management in systems such as the one presented experiences several challenges in the form of bottlenecks and multicast dynamic group sizing is used as a key technique to make resources on the downlink data plane more efficiently managed. The efficiency of the proposed model for the downlink takes on a Skellam distribution shape which is used for performance modeling.
Weak ordering- a new definition and some implications

A model for correct program behavior commonly and often implicitly assumed by programmers is that of sequential consistency, which guarantees that all memory accesses execute atomically and in program order. An alternative programmer’s model, weak ordering, offers greater performance potential, especially for highly parallel shared memory systems. Weak ordering was first defined by Dubois, Scheurich and Briggs in terms of a set of constraints for hardware, which are not necessary for its intuitive goal.
p53 therapy in a patient with Li-Fraumeni syndrome

Li-Fraumeni syndrome is an autosomal dominant disorder that greatly increases the risk of developing multiple types of cancer. The majority of Li-Fraumeni syndrome families contain germ-line mutations in the p53 tumor suppressor gene. We describe treatment of a refractory, progressive Li-Fraumeni syndrome embryonal carcinoma with a p53 therapy (Advexin) targeted to the underlying molecular defect of this syndrome. p53 treatment resulted in complete and durable remission of the injected lesion by fluorodeoxyglucose-positron emission tomography scans with improvement of tumor-related symptoms. With respect to molecular markers, the patient's tumor had abnormal p53 and expressed coxsackie adenovirus receptors with a low HDM2 and bcl-2 profile conducive for adenoviral p53 activity. p53 treatment resulted in the induction of cell cycle arrest and apoptosis documented by p21 and cleaved caspase-3 detection. Increased adenoviral antibody titers after repeated therapy did not inhibit adenoviral p53 activity or result in pathologic sequelae. Relationships between these clinical, radiographic, and molecular markers may prove useful in guiding future application of p53 tumor suppressor therapy. [Mol Cancer Ther 2007;6(5):1478–1482
Specificity of Substrate Recognition by Pseudomonas fluorescens N3 Dioxygenase

Pseudomonas fluorescens N3 is able to grow on naphthalene as the sole carbon and energy source. The mutant TTC1, blocked at the dihydrodiol dehydrogenase level, which can transform the hydrocarbon into the corresponding dihydrodiol, has been used to produce bioconversion products. To rationalize the different grades of conversion obtained with different substrates, a study was performed using non-naphthalene derivatives, including benzenes, conjugated benzenes, and polycyclic aromatic hydrocarbons. The corresponding diols obtained by bioconversion have been isolated and characterized. A theoretical model that considers both energy and geometry factors has been proposed to rationalize the experimental data. Good agreement has been found between the calculated values and the experimental results.
Structure and Molecular Dynamics Simulations of Protein Tyrosine Phosphatase Non-Receptor 12 Provide Insights into the Catalytic Mechanism of the Enzyme

Protein tyrosine phosphatase non-receptor 12 (PTPN12) is an important protein tyrosine phosphatase involved in regulating cell adhesion and migration as well as tumorigenesis. Here, we solved a crystal structure of the native PTPN12 catalytic domain with the catalytic cysteine (residue 231) in dual conformation (phosphorylated and unphosphorylated). Combined with molecular dynamics simulation data, we concluded that those two conformations represent different states of the protein which are realized during the dephosphorylation reaction. Together with docking and mutagenesis data, our results provide a molecular basis for understanding the catalytic mechanism of PTPN12 and its role in tumorigenesis.
A robust tracking method based on two-dimensional histogram and generalized divergence

Due to its robustness and computational efficiency, the mean shift based algorithms have achieved considerable success in object tracking. Color histogram is used in these algorithms to represent the target model. The Bhattacharyya coefficient is employed as the similarity measure to evaluate the difference between the model and the target candidates. In practice, there exist some limits in these approaches. First, images with very different appearances can have similar histograms for the lack of spatial information. Second, the Bhattacharyya coefficient is not quite discriminative, especially in higher dimensions. In this paper, the color information and other spatial features (such as texture etc) are integrated to construct a two-dimensional histogram to represent the target model. To achieve more accuracy of tracking and robustness to background motions, generalized divergence is introduced as a similarity measure. The robustness and accuracy of the present method is demonstrated in the experiments.
Constitutively Active Inflammasome in Human Melanoma Cells Mediating Autoinflammation via Caspase-1 Processing and Secretion of Interleukin-1β*

Interleukin-1β (IL-1β) is a pleiotropic cytokine promoting inflammation, angiogenesis, and tissue remodeling as well as regulation of immune responses. Although IL-1β contributes to growth and metastatic spread in experimental and human cancers, the molecular mechanisms regulating the conversion of the inactive IL-1β precursor to a secreted and active cytokine remains unclear. Here we demonstrate that NALP3 inflammasome is constitutively assembled and activated with cleavage of caspase-1 in human melanoma cells. Late stage human melanoma cells spontaneously secrete active IL-1β via constitutive activation of the NALP3 inflammasome and IL-1 receptor signaling, exhibiting a feature of autoinflammatory diseases. Unlike human blood monocytes, these melanoma cells require no exogenous stimulation. In contrast, NALP3 functionality in intermediate stage melanoma cells requires activation of the IL-1 receptor to secrete active IL-1β; cells from an early stage of melanoma require stimulation of the IL-1 receptor plus the co-stimulant muramyl dipeptide. The spontaneous secretion of IL-1β from melanoma cells was reduced by inhibition of caspase-1 or the use of small interfering RNA directed against ASC. Supernatants from melanoma cell cultures enhanced macrophage chemotaxis and promoted in vitro angiogenesis, both prevented by pretreating melanoma cells with inhibitors of caspases-1 and -5 or IL-1 receptor blockade. These findings implicate IL-1-mediated autoinflammation as contributing to the development and progression of human melanoma and suggest that inhibiting the inflammasome pathway or reducing IL-1 activity can be a therapeutic option for melanoma patients.
Improving hybrid seed production in corn with glyphosate-mediated male sterility.

BACKGROUND Hybrid corn varieties exhibit benefits associated with heterosis and account for most of the corn acreage in the USA. Hybrid seed corn is produced by crossing a female parent which is male-sterile and therefore incapable of self-pollination with a male parent as the pollen donor. The majority of hybrid seed corn is produced by mechanical detasseling which involves physically removing the tassel, a process that is laborious and costly. RESULTS Glyphosate-resistant corn was developed via expression of a glyphosate insensitive 5-enolpyruvyl-shikimate 3-phosphate synthase enzyme (CP4-EPSPS). Experimentation with molecular expression elements resulted in selective reduction of CP4-EPSPS expression in male reproductive tissues. The resulting plant demonstrated sterile tassel following glyphosate application with little to no injury to the rest of the plant. Using (14)C-glyphosate as a marker, we also examined the translocation of glyphosate to the tassel via spray application in a track sprayer to simulate field application. The results allowed optimization of spray parameters such as dose, spray timing and target to maximize tassel delivery of glyphosate for efficient sterilization. CONCLUSION The Roundup hybridization system (RHS) is a novel process for hybrid seed production based on glyphosate-mediated male sterility. RHS replaces mechanical detasseling with glyphosate spray and greatly simplifies the process of hybrid seed corn production.
A Simple Offline Technique for Evaluating the Condition of Aluminum–Electrolytic–Capacitors

This paper presents a very simple technique to estimate the condition of aluminum-electrolytic-capacitors. The aging of aluminum-electrolytic-capacitors is expressed by the increase of their equivalent series resistance (ESR) and the reduction of their capacitance. Thus, the proposed technique is based on the estimation of both the ESR and capacitance values. To implement the proposed technique, the capacitor is fed by a sinusoidal voltage with the required power. The resultant impedance vector defined by the capacitor voltage and current gives enough information to estimate the condition of the capacitor.
Phylogenetic Classification of Trichophyton mentagrophytes Complex Strains Based on DNA Sequences of Nuclear Ribosomal Internal Transcribed Spacer 1 Regions

ABSTRACT Using internal transcribed spacer 1 (ITS1) region ribosomal DNA sequences from 37 stock strains and clinical isolates provisionally termed Trichophyton mentagrophytes complex in Japan, we demonstrated the mutual phylogenetic relationships of these strains. Members of this complex were classified into 3 ITS1-homologous groups and 13 ITS1-identical groups by their sequences. ITS1-homologous group I consists of Arthroderma vanbreuseghemii, T. mentagrophytes human isolates, and several strains of T. mentagrophytes animal isolates. Five strains of Arthroderma simii form a cluster comprising ITS1-homologous group II. The Americano-European and African races of Arthroderma benhamiae, T. mentagrophytes var.erinacei, and one strain of a T. mentagrophytes animal isolate constitute ITS1-homologous group III. According to the phylogenetic tree constructed withTrichophyton rubrum as an outgroup, ITS1-homologous groups I and II comprised a monophyletic cluster and ITS1-homologous group III constituted another cluster which was rather distant from the others in the complex. This system was applicable to the phylogenetic analysis of closely related strains. Using this technique, human and animal isolates of T. mentagrophytes were also clearly distinguishable from each other.
A ground moving target detection and imaging method in Doppler-rate domain for Bistatic forward-looking SAR

Current literatures and reports about Bistatic forward-looking SAR (BFSAR) imaging theories are mostly concentrated on static scene. In this paper, a novel GMT detection and imaging method in Doppler-rate domain for BFSAR is presented. The steps of this method involve bulk-deramp filtering operation, Keystone transform (KT), extend azimuth nonlinear chirp scaling (EA-NLCS) processing and the last detection step based on product second-order ambiguity function (PSAF). After the above steps of the method, if the PSAF of a certain range bin has more than one sharp peak, we can argue that there is a GMT in the relative range bin. Then using the GMT's Doppler rate estimated by PSAF, the echo of GMT can be focused, thus the goals of GMT detection and imaging for BFSAR are achieved. Numerical simulations verify the effectiveness of the proposed method.