Miracle-dz/UniFAR-FTUs huggingface dataset:
Disappearance of an epithelial cell surface‐specific glycoprotein (Epith‐1) associated with epithelial–mesenchymal conversion in sea urchin embryogenesis

Cell surface modification during mesenchyme ingression was examined using a monoclonal antibody (mAb), anti‐Epith‐1 mAb, raised against a protein (Epith‐1) that was confined to the lateral surface of the epithelial cells in embryo of the sea urchin, Temnopleurus hardwicki. The mAb epitope was N‐glycosylated oligosaccharides of 160 kDa monomeric Epith‐1 protein. The glycoprotein was negatively charged, and its isoelectric point (IP) was 4.98. The mAb, however, is not immunologically cross‐reactive with other sea urchin embryos including Hemicentrotus pulcherrimus, Strongylocentrotus nudus, and Scaphechinus mirabilis. Epith‐1 is present initially in the cytoplasm of unfertilized eggs. Cytoplasmic Epith‐1 shifted to the cell surface to be integrated in plasma membrane during the first cleavage, and remained there during early embryogenesis by retaining the same relative molecular mass (Mr). During primary and secondary mesenchyme ingression periods, however, Epith‐1 disappears from the presumptive mesenchyme cell surface that was associated with internalization of the protein. In plutei, an additional anti‐Epith‐1 mAb‐positive protein appears at the 142 kDa region, which was not associated with any visible alteration of the histologic localization of the protein in larvae. Anti‐Epith‐1 mAb IgG did not inhibit the reaggregation of epithelial cells in vitro, which suggests that either the protein is not involved in cell–cell adhesion or that the mAb is not recognizing the active site of the protein.
Towards the Entrepreneurial University

In 1991, a local notable from the Maoposkie voivodship of Poland created a private business school in the town of Nowy SaÎ cz. In a period of ten years, this institution became one of the most successful private higher education institutions in Poland. Basing himself on Jerzy Dietl’s seven criteria for institutional survival, the author describes the steps that he took to build up this institution and to guarantee its survival within its regional and then its national and international environments. According to the author, the steps to the survival and success of the Higher School of Business-National Louis University could serve as a blueprint for the regeneration of higher education in Poland.
Effect of transcutaneous electrical nerve stimulation (TENS) on Barthel Activities of Daily Living (ADL) Index score following stroke

Objective: To evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) and placebo TENS on the level of activities of daily living (ADL) of stroke patients. Setting: A university hospital. Patients: Patients who had had a stroke 30–240 days before entry to a university rehabilitation centre. Design: Controlled design with block randomization and blinded assessment. Intervention: All patients had Todd–Davies exercises. In group 1 (n = 30) TENS with frequency of 100 Hz was used at an intensity that the patient could tolerate; in group 2 (n = 30) patients were given placebo TENS. The treatment protocol consisted of 40 sessions (eight weeks). Outcomes: The Barthel Index for daily living activities was used to measure functional changes over time, and the Ashworth Scale was used to measure spasticity in the elbow, knee and ankle. These measurements were made prior to and following the treatment by assessors unaware of the patient's group allocation. Results: There were 30 patients in each group. Patients in group 1 (active TENS) were more disabled at entry to the study. Statistically significant improvements were recorded in all parameters such as feeding, transfer, hygiene, toileting, bathing, walking, climbing stairs, dressing, bowel and bladder care for group 1 (p<0.001) but only in some items in group 2. The change in total score was significant in both groups but the difference in the change score between the two groups was statistically significant (p<0.001). Spasticity was reduced in the active treatment group. Conclusion: TENS appears to be an effective adjunct in the regaining of motor functions and improving ADL in hemiplegic patients, but the accidental imbalance in severity of disability at entry makes interpretation uncertain.
Comparing high-dimensional confounder control methods for rapid cohort studies from electronic health records

Aims: Electronic health records (EHR), containing rich clinical histories of large patient populations, can provide evidence for clinical decisions when evidence from trials and literature is absent. To enable such observational studies from EHR in real time, particularly in emergencies, rapid confounder control methods that can handle numerous variables and adjust for biases are imperative. This study compares the performance of 18 automatic confounder control methods. Methods: Methods include propensity scores, direct adjustment by machine learning, similarity matching and resampling in two simulated and one real-world EHR datasets. Results & conclusions: Direct adjustment by lasso regression and ensemble models involving multiple resamples have performance comparable to expert-based propensity scores and thus, may help provide real-time EHR-based evidence for timely clinical decisions.
Seeing the unseen: Dr. Harold E. Edgerton and the wonders of Strobe Alley

Harold "Doc" Edgerton's stop-action stroboscopic flash photographs - the spiked diadem of a milk-drop splash, the path of a bullet, a hummingbird's wings - are considered wonders of both art and science. For decades these amazing images poured out of MIT's "Strobe Alley", Doc's name for his lab rooms and the corridor into which so many of his experiments seemed to spill. Previous accounts of this work have focused on the artistic quality of these images. "Seeing the Unseen" differs in its dual focus on the life and the science of this teacher/entrepreneur whose native curiosity led him to fashion imaginative means of stopping time to investigate the details of natural phenomena. A biographical essay by Douglas Collins traces Edgerton's odyssey from Aurora, Nebraska to Cambridge, Massachusetts, where he taught several generations of engineers to think creatively and where he developed the tools that allowed him to capture high-speed photographic images. An essay by Joyce Bedi reviews the historical antecedents of Doc's innovative technology. Intermixed are technical sidebars that explain the tools and techniques of high-speed photography. The essays are accompanied by 143 illustrations from Edgerton's work. The book is accompanied by an "electronic gallery" - a Kodak Portfolio Photo CD with 122 additional images, selected primarily for their aesthetic appeal.
Effects of serum on calcium mobilization in the submandibular cell line A253

The effects of serum on inositol 1,4,5‐trisphosphate (IP3) formation and Ca2+ mobilization in the human submandibular cell line A253 were studied. Exposure of A253 cells to fetal bovine serum (FBS) elicited a 3.3‐fold increase in IP3 formation and a concentration‐dependent transient increase in cytosolic free Ca2+ concentration ([Ca2+]i), which was similar in Ca2+‐containing and Ca2+‐free media. Newborn bovine serum (NBS), but not bovine serum albumin (BSA), induced a similar response. The Ca2+ release triggered by FBS was significantly (88%) reduced by the phospholipase C inhibitor U73122, indicating that Ca2+ release induced by FBS is through the PLC pathway. Pretreatment with the tyrosine kinase inhibitor genistein abolished the FBS‐ and NBS‐induced Ca2+ release, suggesting that tyrosine kinase plays an important role in mediating the Ca2+ release. Pre‐exposure to ATP or thapsigargin (TG) significantly reduced the FBS‐induced [Ca2+]i increase, indicating that Ca2+ release caused by FBS is from the TG‐ or ATP‐sensitive Ca2+ store. While FBS exposure elicited a large Ca2+ release, it reduced Ca2+ influx. Furthermore, FBS significantly inhibited the Ca2+ influx activated by the depletion of intracellular stores by ATP or TG. These results suggest that (1) serum elicits Ca2+ release from ATP‐ and TG‐sensitive stores, which is mediated by IP3; (2) the serum‐induced Ca2+ release may be modulated by a tyrosine kinase‐associated process; and (3) serum strongly inhibits Ca2+ influxes including the store depletion‐activated Ca2+ influx. J. Cell. Biochem. 73:458–468, 1999. © 1999 Wiley‐Liss, Inc.
Leveraging Social Media and Multimedia Services for QoE Enhancement in Cultural Industries

The advancement of ICT has brought about significant changes in the way the cultural and creative industries work as well as in the experience they offer. However there is still a lot of potential that can be leveraged to advance the state of the art in the way the public shares collective cultural experiences. In this paper, we employ different concepts and technologies, such as high quality multimedia content production and delivery, social media interaction, and methodologies for monitoring and analyzing social network activity, to revamp the experience offered in cultural and educational centres. In addition to an increased Quality of Experience, the proposed system involves significant benefits for the organizers as well, providing them with feedback based on social analytics. The experimental system has been successfully deployed and used in the "Hellenic Cosmos" cultural center.
NCAP: Network-Driven, Packet Context-Aware Power Management for Client-Server Architecture

The rate of network packets encapsulating requests from clients can significantly affect the utilization, and thus performance and sleep states of processors in servers deploying a power management policy. To improve energy efficiency, servers may adopt an aggressive power management policy that frequently transitions a processor to a low-performance or sleep state at a low utilization. However, such servers may not respond to a sudden increase in the rate of requests from clients early enough due to a considerable performance penalty of transitioning a processor from a sleep or low-performance state to a high-performance state. This in turn entails violations of a service level agreement (SLA), discourages server operators from deploying an aggressive power management policy, and thus wastes energy during low-utilization periods. For both fast response time and high energy-efficiency, we propose NCAP, Network-driven, packet Context-Aware Power management for client-server architecture. NCAP enhances a network interface card (NIC) and its driver such that it can examine received and transmitted network packets, determine the rate of network packets containing latency-critical requests, and proactively transition a processor to an appropriate performance or sleep state. To demonstrate the efficacy, we evaluate on-line data-intensive (OLDI) applications and show that a server deploying NCAP consumes 37~61% lower processor energy than a baseline server while satisfying a given SLA at various load levels.
Towards Satisfying an Application Level Quality Measure via a Neural Network TCP-like Protocol

A new TCP-like protocol is proposed in this paper aiming at regulating the packet round trip to satisfy a user imposed desired application sending time. For this purpose linear in the weights neural networks are employed to construct an on-line model for the estimated round trip depending on source rate (control input) and congestion level which is directly measured from the network via monitoring the state of the ECN bit for each packet acknowledgement. When the network has enough resources to support the user requirement, the neural network based rate control algorithm guarantees the uniform ultimate boundedness of the achieved round trip with respect to an arbitrarily small neighborhood of the desired round trip. In the unfortunate case of high congestion, the controller reduces the rate to the point of congestion escaping. To improve the achievable sending time, introducing the notion of communication channels, whose number is regulated via an appropriately designed algorithm, parallelizes the transmission process. We assume the nonexistence of uncontrollable traffic flows (e.g., UDP) as well as negligible propagation delays. Simulation studies illustrate the approach, highlighting various performance measures (i.e. fairness, buffer level, router utilization) and verifying theoretical analysis.
Vie professionnelle et naissance : la charge de la conciliation repose essentiellement sur les femmes

Si la naissance d'un enfant ne modifie guere l'activite professionnelle des hommes, les femmes sont 40 % a declarer un changement de situation. Les interruptions temporaires ou la reduction du temps de travail sont plus frequentes pour le deuxieme ou le troisieme enfant que pour le premier. Les femmes les mieux inserees sur le marche du travail et les femmes en situation monoparentale ou ayant un conjoint au chomage sont celles qui interrompent ou diminuent le moins leur activite professionnelle. Les moins diplomees, les plus precaires ou celles ayant un conjoint actif sont en revanche plus nombreuses a cesser de travailler.
POST-IMPLEMENTATION SURVEILLANCE OF A NON-PHARMACOLOGICAL HEALTH TECHNOLOGY WITHIN A NATIONAL HEALTH SERVICE

Objectives: The aim of this study was to describe 8-year results from post-implementation surveillance of neuroreflexotherapy (NRT), a health technology proven effective for treating neck and back pain. Methods: Post-implementation surveillance included all patients undergoing NRT across five regions within the Spanish National Health Service (SNHS). Validated methods were used to assess pain, disability, adverse events, use of health resources, and patient satisfaction. Logistic regression models were developed to identify the variables associated with the risk of a pain episode requiring more than one NRT intervention. The number of relapses among discharged patients during the 8-year period was calculated. Results: Between January 1, 2004, and June 30, 2012, 9,023 patients (median age: 53 years), presenting 11,384 subacute (25.2 percent) and chronic (74.8 percent), neck or back pain episodes, were discharged after receiving NRT. Spinal pain improved in 89 percent of cases, 83 percent abandoned drugs, and 0.02 percent required spine surgery. The only adverse event was skin discomfort (8.0 percent of patients). Number of patient complaints was 0, and answers to a standardized questionnaire reflected a high degree of satisfaction (response rate: 76.7 percent). Of the pain episodes, 18.9 percent required more than one NRT intervention; logistic regression models identified the variables associated with this. Over the 8-year period, the proportion of discharged patients referred for treatment due to relapse at the same level for neck, thoracic, and low back pain, was 16.4 percent, 6.5 percent, and 14.5 percent respectively. Conclusions: Post-marketing surveillance for a non-pharmacological technology is feasible within the SNHS. These results support generalizing NRT across the entire SNHS under the current validated application conditions.
Forecasting Tourist Arrivals to Turkey

Modeling and forecasting techniques of the tourist arrivals are many and diverse. Th ere is no unique model that exactly outperforms the other models in every situation. Actually a few studies have realized modeling and forecasting the tourist arrivals to Turkey and these studies have not focused on the total tourist arrivals. Th ese studies have focused on the tourist arrivals to Turkey country by country (or OECD countries). In addition to this, structural time series models have not been used in modeling and forecasting the tourist arrivals to Turkey. In this sense, this paper is the fi rst study which uses the seasonal autoregressive integrated moving average model and the structural time series model in order to forecast the total tourist arrivals to Turkey. Two diff erent models are developed to forecast the total tourist arrivals to Turkey using monthly data for the period 2002-2013. Th e results of the study show that two models provide accurate predictions but the seasonal autoregressive integrated moving average model produces more accurate short-term forecasts than the structural time series model. It is noted that the seasonal autoregressive integrated moving average model shows a very successful performance in the forecasting the total tourist arrivals to Turkey.
Organizational Properties in a Cutaneous Memory-Scanning Task

An experiment investigated the notion that organizational properties operate in a memory-scanning task using cutaneous stimuli. The results indicated that the open-closed nature of the positive set is a significant factor in a cutaneous memory-scanning task. Set-size was not a significant factor. The data suggest there are some organizational processes in a cutaneous memory-scanning cask, however, these processes do not seem to be completely analogous to those used in visual and auditory memory-scanning tasks.
An Analysis on the Relationship between Parenting Styles and Self Esteem of Students of a University in Malaysia: A Case Study

This research examines about the relationship between parenting style and self-esteem among students in a faculty at a Public University in Malaysia. The study involved 120 students and was analysed by using the descriptive and inferential statistics. Parenting styles was measured by "Parental Authority Questionnaire" (PAQ) instrument while the self-esteem was measured by "Rosenberg Self-Esteem Inventory" (RSES). The data were analyzed by using the "Statistical Package for Social Science" version 18.0. All of the data were analyzed using Pearson correlation and descriptive statistics. As a conclusion, the results show that permissive parenting style is the dominant parenting style used by the parents of university students. In addition, most of the university students have high level of self-esteem. Besides this, it is also found that there is a significant relationship between parenting style and self-esteem among university students. The study is also found that there is a positive relationship between authoritative and permissive parenting style with self-esteem. Meanwhile, the study found that the authoritarian parenting style has a negative relationship with students' self-esteem DOI: 10.5901/mjss.2015. v6n4s3p300
Multi-source high resolution remote sensing image fusion based on intelligent decision

Application fields of multisource high resolution remote sensing image fusion are expending ceaselessly. Especially, commercial remote sensing satellite data and image fusion algorithms are constantly emerging. This paper proposed an intelligent decision strategy that can be used to query various remote sensing data for recommending the optimal image fusion data combination and appropriate fusion algorithm. The system architecture was defined as four layers including interaction layer, service layer, component layer, and data layer. In order to extend more plug-ins, we introduced the Zero-C distributed service framework to invoke different types of service interface. Besides, a main interface of intelligent inference system is developed for users to submit image fusion tasks.
GROWTH CHARTS BASED LONGITUDINAL STUDY OF MALAYSIAN CHILDREN FROM BIRTH TO YEARS

A child's growth achievement is a useful indicator of his well-being and nutritional status. This can easily be assessed by comparing his growth parameters such as weight, length and head ci rcumference, with norms or standards derived from a relatively healthy population of genetically similar children. Such standards are essential to professionals working with children, for example paediatricians, general practitioners, health officers and nurses.
The origins of metallurgy in central Italy: new radiometric evidence

Precision radiocarbon dating continues to bring historical order into key moments of social and economic change, such as the use of metals. Here the author dates human bone in graves with metal artefacts and shows that copper, antimony and silver were being fashioned into daggers and beads in west central Italy by the early to mid fourth millennium cal BC; but the new-fangled objects had not reached contemporary cemeteries on the other side of the Apennines. We can perhaps look forward to a time when the arrival of metallurgy in Europe is neither diffusionary nor piecemeal, but the result of real historical events and social contacts, mapped for us by radiocarbon.
Identification of Glycosyltransferase 8 Family Members as Xylosyltransferases Acting on O-Glucosylated Notch Epidermal Growth Factor Repeats*

The epidermal growth factor repeats of the Notch receptor are extensively glycosylated with three different O-glycans. O-Fucosylation and elongation by the glycosyltransferase Fringe have been well studied and shown to be essential for proper Notch signaling. In contrast, biosynthesis of O-glucose and O-N-acetylglucosamine is less well understood. Recently, the isolation of the Drosophila mutant rumi has shown that absence of O-glucose impairs Notch function. O-Glucose is further extended by two contiguous α1,3-linked xylose residues. We have identified two enzymes of the human glycosyltransferase 8 family, now named GXYLT1 and GXYLT2 (glucoside xylosyltransferase), as UDP-d-xylose:β-d-glucoside α1,3-d-xylosyltransferases adding the first xylose. The enzymes are specific for β-glucose-terminating acceptors and UDP-xylose as donor substrate. Generation of the α1,3-linkage was confirmed by nuclear magnetic resonance. Activity on a natural acceptor could be shown by in vitro xylosylation of a Notch fragment expressed in a UDP-xylose-deficient cell line and in vivo by co-expression of the enzymes and the Notch fragment in insect cells followed by mass spectrometric analysis of peptide fragments.
Biochemical and kinetic analyses of NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

The biochemical properties of the RNA-dependent RNA polymerase (RdRp) of the hepatitis C virus were analyzed. A hexahistidine affinity-tagged NS5B fusion protein was expressed with recombinant baculoviruses in insect cells and purified to near homogeneity. Enzymatic activity of the purified protein was inhibited by KCl or high concentrations of NaCl and was absolutely dependent on Mg2+, which could be replaced by Mn2+. NS5B was found to be processive and able to copy long heteropolymeric templates with an elongation rate of 150-200 nucleotides/min at 22 degreesC. Kinetic constants were determined for all four nucleoside triphosphates and different templates. In case of a heteropolymeric RNA template corresponding to the last 319 nucleotides of the hepatitis C virus genome, Km values for UTP, GTP, ATP, and CTP were approximately 1.0, approximately 0.5, approximately 10, and approximately 0.3 microM, respectively. The profile of several inhibitors of RdRp activity and substrate analogs indicated that the enzyme has a strong preference for ribonucleoside 5'-triphosphates and that it closely resembles 3Dpol of picornaviruses.
Accurate modeling of trench isolation induced mechanical stress effects on MOSFET electrical performance

A new approach is presented aimed at modeling mechanical stress effects which impact MOSFET electrical behavior. It is successful in accounting for mobility variations experimentally evidenced on complex MOSFET geometries. The newly developed mobility model proves to be an efficient way to include mechanical stress effects into standard simulation models. We show that stress effects can and should be taken into account in the IC design phase in present and sub 90 nm nodes CMOS generations.