Miracle-dz/UniFAR-FTUs huggingface dataset:
High prevalence of postprandial and orthostatic hypotension among geriatric patients admitted to Dutch hospitals.

BACKGROUND Previous studies have indicated that postprandial hypotension (PPH) and orthostatic hypotension (OH) occur infrequently together. As data on geriatric patients in hospitals are scarce, we investigated the prevalence of PPH and OH and their combined occurrence. Our study sample included patients admitted to two geriatric departments in Dutch hospitals. METHODS During 9 months, hemodynamic changes were measured with Spacelab 90207 after standing and after meals in all eligible patients. PPH is defined as a meal-related decline in systolic blood pressure (SBP) > or =20 mmHg, OH after standing up. RESULTS Eighty-five patients (44 men), mean age 80 +/- 7 years (range 60-98 years), with 4 +/- 2 diseases and 6 +/- 3 prescriptions, were included. PPH was present in 57 patients (67%) with a significant postmeal SBP decrease of 34 +/- 4 mmHg. OH was present in 44 patients (52%) with a mean SBP decline of 44 +/- 4 mmHg after standing. Thirty-two patients (37%) had OH and PPH. Only 16 patients (19%) had neither OH nor PPH. Symptoms of PPH were present in 65% of patients, with syncope (in five patients) and sleepiness as the most common symptoms. OH was symptomatic in 61% of patients, with dizziness and risk for falls as the most common symptoms. CONCLUSIONS PPH and OH are more common in geriatric patients than was previously appreciated, with a high statistical probability that OH and PPH occur simultaneously. There is little overlap in symptoms of OH (dizziness, fall risk) versus PPH (sleepiness, syncope), which can play an important role in diagnosis. Because of the high prevalence of symptomatic PPH and OH, blood pressure measurements for diagnosing hypotensive syndromes should be part of a comprehensive geriatric assessment.
Simple Energy-Aware Algorithms for Selecting a Server in a Scalable Cluster

It is critical to reduce the electric energy consumed in server clusters in order to realize eco society. In our previous studies, a server is selected to perform a process by estimating the termination time of every current process and then the electric energy consumption of servers. However, it is not easy and takes time to collect the state of each process and estimate the termination time of each process. In this paper, we propose SLEA (simple locally energy-aware) and SGEA (simple globally energy-aware) algorithms to select a server where only the number of processes on each server is used. In the evaluation, we show the electric energy consumption and active time of the servers and the average execution time of processes can be reduced in the SLEA and SGEA algorithms.
Developing successful diversionary schemes for youth from remote Aboriginal communities

This report explores the experiences and aspirations of youth in Wadeye, a remote Aboriginal community in the Northern Territory which has become synonymous with the deviant behaviours of its young people. The research was undertaken over a three year period, and builds upon a previous ten year period of community based research. As such it forms a unique longitudinal study of young people during a period of extreme change in their lives. The research applied a mixed methods approach, utilising ethnography, interviews and the application of a community wide survey. Although young community based people were the primary focus of the study, the research also included the wider community perspectives, service provide rs and a sample of imprisoned community members. The proliferation of gangs in the Wadeye community has become a primary focus for outsiders' interpretation of social issues in the community. These gangs have been defined by their violent and oppositional cultures. This period of research and the research which preceded it, emphasise the complexity of gang cultures and gang dynamics in this community. The report also emphasises that a primary focus on gangs serves to obscure other factors influencing young people's lives and behaviours. This includes those youth who do not engage in deviant behaviour, who attend school and progress to employment. It also includes youth who engage in non-gang related violent and anti-social behaviour. The report argues that effective service delivery and the development of appropriate diversion activities for young people must recognise the diversity and complexity of the youth experience in the community and recognise and develop their current strengths. Feedback from elders, young people and long-term community workers, advocates that more partnership approaches to further research and program evaluation must become an integral part of the process. Involving young people themselves as part of this research process will provide opportunities to create new roles for them and to establish a positive foundation for the future of the community.
Metabolic Labeling of DNA by Purine Analogues in Vivo

The 2′-deoxyadenosine analogue “EdA” efficiently labels newly synthesized DNA with alkyne groups in vivo without inhibiting cell cycle progression or embryonic development. This provides the first demonstration that a bio-orthogonal functional group can be metabolically incorporated into DNA through endogenous pathways by addition of a purine analogue to cells.
SeedStor: A Germplasm Information Management System and Public Database

Abstract SeedStor (https://www.seedstor.ac.uk) acts as the publicly available database for the seed collections held by the Germplasm Resources Unit (GRU) based at the John Innes Centre, Norwich, UK. The GRU is a national capability supported by the Biotechnology and Biological Sciences Research Council (BBSRC). The GRU curates germplasm collections of a range of temperate cereal, legume and Brassica crops and their associated wild relatives, as well as precise genetic stocks, near-isogenic lines and mapping populations. With >35,000 accessions, the GRU forms part of the UK’s plant conservation contribution to the Multilateral System (MLS) of the International Treaty for Plant Genetic Resources for Food and Agriculture (ITPGRFA) for wheat, barley, oat and pea. SeedStor is a fully searchable system that allows our various collections to be browsed species by species through to complicated multipart phenotype criteria-driven queries. The results from these searches can be downloaded for later analysis or used to order germplasm via our shopping cart. The user community for SeedStor is the plant science research community, plant breeders, specialist growers, hobby farmers and amateur gardeners, and educationalists. Furthermore, SeedStor is much more than a database; it has been developed to act internally as a Germplasm Information Management System that allows team members to track and process germplasm requests, determine regeneration priorities, handle cost recovery and Material Transfer Agreement paperwork, manage the Seed Store holdings and easily report on a wide range of the aforementioned tasks.
3,3′-Dimethyl-1,1′-(propane-1,3-diyl)diimidazol-1-ium bis(hexafluorophosphate)

In the title compound, C11H18N4 2+·2PF6 −, the dihedral angle between the two planar imidozlium rings is 6.1 (2)°. Both [PF6]− anions are disordered [occupancies 0.65 (2):0.35 (2) and 0.59 (5):0.41 (5)]. The crystal packing is stabilized by intermolecular C—H⋯F hydrogen bonds which link two molecules, forming centrosymmetric dimers.
World Food Needs and the Optimal Allocations of Lands

In order to assess the future world food demand/supply balance for the next century, in relation to the land uses, we develop a model in which the society has to supply two types of food demand, namely, processed crop products and meat and dairy products. From the supply side, the society can resort to different classes of land. Each class of land can be allocated wholly or partially either to crop cultivation or to pasture or last to be lain fallow. Primary crop production can be transformed either into processed crop products to satisfy final needs, or into intermediate livestock products used as inputs within the intensive industrial farming system. The livestock products can also be obtained from the extensive grazing system. The increase in world population together with the increase in the per capita income boost the final demand for food products. In order to meet the future food demands, the structure of the livestock production system should be modified, the share of the intensive production system having to be increased. With respect to the optimal allocation of land, we have established different degrees of land scarcity. More precisely, as the land is getting scarcer, the share of the livestock products stemming from the intensive production system is steadily increasing. Thus, the cropland is rising at the expense of pastureland. The shadow value assigned to the different land classes is steadily increasing throughout the next century.
The Experimental Design Assistant

Addressing the common problems that researchers encounter when designing and analysing animal experiments will improve the reliability of in vivo research. In this article, the Experimental Design Assistant (EDA) is introduced. The EDA is a web-based tool that guides the in vivo researcher through the experimental design and analysis process, providing automated feedback on the proposed design and generating a graphical summary that aids communication with colleagues, funders, regulatory authorities, and the wider scientific community. It will have an important role in addressing causes of irreproducibility.
Going native? Flower use by bumblebees in English urban gardens.

BACKGROUND AND AIMS Although urban gardens provide opportunities for pollinators in an otherwise inhospitable environment, most garden plants are not native to the recipient biogeographical region and their value to local pollinators is disputed. This study tested the hypothesis that bumblebees foraging in English urban gardens preferentially visited sympatric Palaearctic-range plants over species originating outside their native range. METHODS Twenty-seven surveys of flower availability and bumblebee visitation (Bombus spp.) were conducted over a 3-month summer period. Plants were categorized according to whether they were native British, Palaearctic or non-Palaearctic in origin. A phylogeny of the 119 plant species recorded was constructed and the relationship between floral abundance and the frequency of pollinator visits investigated by means of phylogenetically independent contrasts. Differentiation in utilization of plant species by the five bumblebee species encountered was investigated using niche overlap analyses. KEY RESULTS There was conflicting evidence for preferential use of native-range Palaearctic plant species by bumblebees depending on which plants were included in the analysis. Evidence was also found for niche partitioning between species based on respective preferences for native and non-native biogeographical range plants. Two bumblebees (Bombus terrestris and B. pratorum) concentrated their foraging activity on non-Palaearctic plants, while two others (B. hortorum and B. pascourum) preferred Palaearctic species. CONCLUSIONS The long-running debate about the value of native and non-native garden plants to pollinators probably stems from a failure to properly consider biogeographical overlap between plant and pollinator ranges. Gardeners can encourage pollinators without consideration of plant origin or bias towards 'local' biogeographical species. However, dietary specialist bumblebees seem to prefer plants sympatric with their own biogeographical range and, in addition to the cultivation of these species in gardens, provision of native non-horticultural ('weed') species may also be important for pollinator conservation.
Endophyte Chaetomium globosum D38 and its elicitors promote tanshinones accumulation of Salvia miltiorrhiza

Due to the low yield of tanshinones and their analogues in Salvia miltiorrhiza, there are all kinds of stimulation strategies having been applied to improve tanshinones output in plant tissue cultures. Endophytic fungi have formed various different relationships with their host plants withstanding host and environmental factors, including symbiotic, mutualistic, commensalistic, and parasitic. Thus we take the assumption that endophytic fungi may be an emerging microbial tool used to promote secondary metabolism, which will promote the production of active compounds through endophyte-based biology method. Our study therefore aimed to examine the effects of live endophytic fungus Chaetomium globosum D38 and its elicitors on the accumulation of tanshinones in hairy root cultures of Salvia miltiorrhiza. C. globosum D38 mainly colonized in the intercellular gap of xylem parenchyma cells of S. miltiorrhiza hairy root, during long term co-existence without any toxicity against S. miltiorrhiza hairy root. Moreover, both of the live fungus and its mycelia extracts could induce the production of tanshinones, in special dihydrotanshinone I and cryptotanshinone. The effects of mycelia extracts were much stronger than that of the live fungus on tanshinones synthesis, which increased the transcriptional activity of genes with repect to tanshinone biosynthetic pathway obviously. Our results indicated that both of the live C. globosum D38 and its mycelia extracts could be utilized for tanshinones accumulation in S. miltiorrhiza hairy root. What’s more, D38 also could be made into biotic fertilizer applying into S.miltiorrhiza seddlings, which not only promoted host growth but the tanshinones and phenylpropionic acid accumulation. In the soil environment, D38 had formed bitrophic and mutual beneficial relationship with the host and enhanced the primary metabolism on the whole so as to have facilitative effects on phenylpropionic acid accumulation. To sum up, Chaetomium globosum D38 was a highly effective endophytic fungus for S. miltiorrhiza.
Vendor selection using fuzzy C means algorithm and analytic hierarchy process

Vendor selection is a strategic issue in supply chain management for any organization to identify the right supplier. Such selection in most cases is based on the analysis of some specific criteria. Most of the researches so far concentrate on multi-criteria decision-making analysis. Though many approaches have been proposed, analytic hierarchy process (AHP) is the most well known as it can deal with a very complex criteria structure. In AHP, the selected criteria are ranked and organized in a hierarchical order from generic to specific to formulate the problem. Though this order of ranking is acceptably logical, it incurs a huge computational complexity when a large number of alternatives are considered as the selection criteria. Moreover, the AHP may generate wrong selection due to computational error. To address these limitations, a novel model namely vendor selection using fuzzy c-means algorithm and analytic hierarchy process (VFA) is presented in this paper by integrating the fuzzy c-means clustering (FCM) algorithm with analytic hierarchy process (AHP). The outcome of the proposed VFA algorithm is compared with the basic AHP algorithm and VFA outperforms the basic AHP and reduces the computational complexity of AHP by a factor of 7. Keywords: Vendor selection problem, analytical hierarchy process, FCM clustering algorithm, decision support system.
Compact circular polarization microstrip antenna design

In this paper, a novel compact circular polarization microstrip antenna is proposed. The patch size is the same with the ground, which reduces the antenna size dramatically, while the performance of the proposed antenna is comparable with the conventional microstrip antenna. With this novel design, the antenna size is reduced by 28%. A prototype of the proposed antenna is designed, implemented and verified experimentally.
Temporal profile of intracranial pressure and cerebrovascular reactivity in severe traumatic brain injury and association with fatal outcome: An observational study

Background Both intracranial pressure (ICP) and the cerebrovascular pressure reactivity represent the dysregulation of pathways directly involved in traumatic brain injury (TBI) pathogenesis and have been used to inform clinical management. However, how these parameters evolve over time following injury and whether this evolution has any prognostic importance have not been studied. Methods and findings We analysed the temporal profile of ICP and pressure reactivity index (PRx), examined their relation to TBI-specific mortality, and determined if the prognostic relevance of these parameters was affected by their temporal profile using mixed models for repeated measures of ICP and PRx for the first 240 hours from the time of injury. A total of 601 adults with TBI, admitted between September 2002 to January 2016, and with high-resolution continuous monitoring from a single centre, were studied. At 6 months postinjury, 133 (19%) patients had a fatal outcome; of those, 88 (78%) died from nonsurvivable TBI or brain death. The difference in mean ICP between those with a fatal outcome and functional survivors was only significant for the first 168 hours after injury (all p < 0.05). For PRx, those patients with a fatal outcome also had a higher (more impaired) PRx throughout the first 120 hours after injury (all p < 0.05). The separation of ICP and PRx was greatest in the first 72 hours after injury. Mixed models demonstrated that the explanatory power of the PRx decreases over time; therefore, the prognostic weight assigned to PRx should similarly decrease. However, the ability of ICP to predict a fatal outcome remained relatively stable over time. As control of ICP is the central purpose of TBI management, it is likely that some of the information that is reflected in the natural history of ICP changes is no longer apparent because of therapeutic intervention. Conclusions We demonstrated the temporal evolution of ICP and PRx and their relationship with fatal outcome, indicating a potential early prognostic and therapeutic window. The combination of dynamic monitoring variables and their time profile improved prediction of outcome. Therefore, time-driven dynamic modelling of outcome in patients with severe TBI may allow for more accurate and clinically useful prediction models. Further research is needed to confirm and expand on these findings.
Precoder Design for K-User Interference Channels with Finite Alphabet Signals

We consider a MIMO K-user interference channel with finite alphabet signaling, and design an optimal precoder for maximizing the sum mutual information between all transmitter-receiver pairs. Perfect channel knowledge is assumed to be available at all the transmitters, but, decoding of the interfering signals is not done at any receiver. A gradient descent algorithm is employed for maximizing the sum mutual information. Simulation results for the three user interference channel show that when compared to conventional schemes which maximize the signal-to-interference plus noise ratio or minimize the mean squared error, the proposed design achieves a significantly better bit error rate performance. Along with the proposed precoder, the minimum distance detector which decodes the desired signal (while treating interference as colored Gaussian noise with a known covariance) was utilized at all the receivers, in order to get this enhanced performance.
Protective effects of placental growth factor on retinal neuronal cell damage

Placental growth factor (PlGF) is a member of the vascular endothelial growth factor family. Although it has been reported that PlGF protects against neuronal damage in the brain, little is known about the effects of PlGF in the retina. Therefore, we investigated the effects of PlGF on retinal neuronal cells. To evaluate the effects of PlGF against L‐buthionine‐(S,R)‐sulfoximine (BSO)/glutamate cell death, oxygen–glucose deprivation (OGD)‐induced cell death, and light‐induced cell death, RGC‐5 and 661W cells were used. We evaluated the mechanism responsible for the protective effects of PlGF against retinal neuronal cell death by performing the examinations with U1026, which is a mitogen‐activated protein kinase (MEK) inhibitor, and LY294002, which is a phosphoinositide 3‐kinase (PI3K) inhibitor. In addition, we measured caspase‐3/7 activity in RGC‐5 cells and 661W cells. PlGF protected against RGC‐5 cell death induced by BSO/glutamate and OGD and against 661W cell death induced by light irradiation. Moreover, an anti‐PlGF antibody negated these protective effects. The protective effects of PlGF against OGD‐induced RGC‐5 cell death and light‐induced 661W cell death were suppressed by using an anti‐PlGF antibody, U1026, and LY294002. Treatment with PlGF suppressed caspase‐3/7 activity in both cell lines. We demonstrated for the first time that PlGF exerts a protective effect by inhibiting the activation of caspase‐3/7 through the MEK and PI3K pathway in retinal neuronal cells. These data suggest that PlGF may be an important protective factor in the retina. © 2013 Wiley Periodicals, Inc.
The mitochondrial genomes of three lineages of Asian yellow pond turtle, Mauremys mutica

Abstract The complete mitochondrial genomes of three lineages (N, TW and S) of Mauremys mutica are determined in this study. The total lengths of the mitogenomes were 16,758 bp for N, 16 500bp for TW, and 16 494bp for S. The nucleotide composition was 26.3–27% for T, 26.2–26.8% for C, and 33.8–33.9% for A. The genomes encoded 37 genes typically found in other vertebrates. Three CSBs were identified, and the CSB1 were variable. A long tandem repeats of (TTATTATA) 30 were found in the control region of N mitogenome, but none in TW and S lineage. These sequences would be useful for the phylogenetic and conservation studies of Asian endangered turtles.
Sexually-Integrated Workplaces and Divorce: Another Form of On-the-Job Search

As women have entered the work force and occupational sex segregation has declined, workers experience increased contact with the opposite sex on the job. The sex mix a worker encounters on the job should affect the cost of search for alternative mates and therefore the probability of divorce. This paper uses 1990 Census data to calculate the sex mix by industry-occupation cell. These results are then used to predict divorce among ever-married respondents in the 1990 Census and the NLSY79. The results indicate that those who work with a larger fraction of workers of the opposite sex are more likely to be divorced.
Unicompartmental Tibial Hemiarthroplasty Early Results of the UniSpacer™ Knee

An intra-articular metallic spacer is evaluated for the treatment of isolated medial compartment OA. It is proposed that this implant can provide axial correction for a varus deformity, eliminate the pseudolaxity of the MCL, improve knee function, maintain ROM, and provide pain relief. One-and 2-year data are presented on 71 UniSpacer™ Knee System implants that were implanted in 67 patients (four had bilateral surgeries). The mean age and weight of these patients was 54 years and 94 kg (207 lb), respectively. The heaviest patient in the group weighed 168 kg (370 lb). All knees were evaluated using the Knee Society clinical rating system, Lysholm scoring scale, radiographic limb alignment, and ROM. The mean Knee Society knee score improved 169% in the 1-year group and 193% in the 2-year group. The mean Knee Society function score improved 31% and 65%, respectively. The mean Lysholm score improved 88% and 140%, respectively. Five implants (7%) were revised to total knee arthroplasty (TKA) and 10 implants (14%) were revised to another UniSpacer™ Knee System implant. The early results suggest that an intra-articular metallic spacer is a viable treatment option for OA in the younger patient.