Miracle-dz/UniFAR-FTUs huggingface dataset:
The Use of Carbonaceous Particle Exposure Metrics in Health Impact Calculations

Combustion-related carbonaceous particles seem to be a better indicator of adverse health effects compared to PM2.5 and PM10. Historical studies are based on black smoke (BS), but more recent studies use absorbance (Abs), black carbon (BC) or elemental carbon (EC) as exposure indicators. To estimate health risks based on BS, we review the literature regarding the relationship between Abs, BS, BC and EC. We also discuss the uncertainties associated with the comparison of relative risks (RRs) based on these conversions. EC is reported to represent a proportion between 5.2% and 27% of BS with a mean value of 12%. Correlations of different metrics at one particular site are higher than when different sites are compared. Comparing all traffic, urban and rural sites, there is no systematic site dependence, indicating that other properties of the particles or errors affect the measurements and obscure the results. It is shown that the estimated daily mortality associated with short-term levels of EC is in the same range as PM10, but this is highly dependent on the EC to BS relationship that is used. RRs for all-cause mortality associated with short-term exposure to PM10 seem to be higher at sites with higher EC concentrations, but more data are needed to verify this.
XIRQL: a query language for information retrieval in XML documents

Based on the document-centric view of XML, we present the query language XIRQL. Current proposals for XML query languages lack most IR-related features, which are weighting and ranking, relevance-oriented search, datatypes with vague predicates, and semantic relativism. XIRQL integrates these features by using ideas from logic-based probabilistic IR models, in combination with concepts from the database area. For processing XIRQL queries, a path algebra is presented, that also serves as a starting point for query optimization.
Network ‘Small-World-Ness’: A Quantitative Method for Determining Canonical Network Equivalence

Background Many technological, biological, social, and information networks fall into the broad class of ‘small-world’ networks: they have tightly interconnected clusters of nodes, and a shortest mean path length that is similar to a matched random graph (same number of nodes and edges). This semi-quantitative definition leads to a categorical distinction (‘small/not-small’) rather than a quantitative, continuous grading of networks, and can lead to uncertainty about a network's small-world status. Moreover, systems described by small-world networks are often studied using an equivalent canonical network model – the Watts-Strogatz (WS) model. However, the process of establishing an equivalent WS model is imprecise and there is a pressing need to discover ways in which this equivalence may be quantified. Methodology/Principal Findings We defined a precise measure of ‘small-world-ness’ S based on the trade off between high local clustering and short path length. A network is now deemed a ‘small-world’ if S>1 - an assertion which may be tested statistically. We then examined the behavior of S on a large data-set of real-world systems. We found that all these systems were linked by a linear relationship between their S values and the network size n. Moreover, we show a method for assigning a unique Watts-Strogatz (WS) model to any real-world network, and show analytically that the WS models associated with our sample of networks also show linearity between S and n. Linearity between S and n is not, however, inevitable, and neither is S maximal for an arbitrary network of given size. Linearity may, however, be explained by a common limiting growth process. Conclusions/Significance We have shown how the notion of a small-world network may be quantified. Several key properties of the metric are described and the use of WS canonical models is placed on a more secure footing.
Vegas-W: An Enhanced TCP-Vegas for Wireless Ad Hoc Networks

The performance of TCP-Vegas is not satisfactory in multihop ad hoc networks over IEEE 802.11 MAC protocol. We analyze the problem with a unified network model and simulation results. We observe that the aggregate throughput of all traffics decreases as the load of the network increases. The main reasons lie in Vegas's large minimum congestion window, large reset slow start threshold and aggressive window increase policy. To fix these problems, we propose a modified TCP protocol based on TCP-Vegas for multihop ad hoc networks, called Vegas- W. We extend the congestion window to fraction; change the probing mechanisms of legacy TCP-Vegas in both slow start and congestion avoidance and update slow start threshold tracking the stable window. We evaluate the performance of Vegas-W through ns-2. Extensive simulation results under a variety of scenarios show that Vegas-W can improve the throughput up to 87% over legacy TCP-Vegas and up to 27% over FeW, which is another improved algorithm based on TCP-Newreno scenarios.
(Un)veiling equity: a critical analysis of the insider and outsider roles of a Muslim female Shi’i educator in academy

This is a critical personal narrative of a Canadian Middle-Eastern Muslim female Shi’i educator’s experiences in a Western academy. The different cultural and religious backgrounds that shape a Muslim woman’s academic work and her understanding of social justice are described. Specifically, the author describes religio-historical figures and the counter-narratives of women of color in the author’s life responsible for shaping her appreciation of the importance of engaging in social justice and equity. The subjectivity in this work is manifested as an alignment with her religious beliefs and doctrine that draws from a counter-narrative (i.e. the Shi’i narrative of Karbala and, more broadly, the marginalized and dissenting ideological position of Shi’ is in relation to global Islam). Her upbringing with and introduction to Shi’i rituals, empower her understanding towards issues related to justice, equal rights, and loyalty. Throughout her narrative, the author utilizes the role of a researcher as an insider and outsider based on religious and feminist approaches. Three significant themes are noted: (a) the critical role of spirituality as a powerful catalyst and feminist for transformative change; (b) the role of reflexive skills and self-criticism as a means to balance religious and academic identities; and (c) the import role of ‘border-crossers’ in negotiating and connecting between religious and academic worlds. Insights about the experiences associated with minority Shi’i Muslim female graduate educators and the importance of being critically reflective when working towards social justice and equity are provided.
“Slow” Voltage-Dependent Inactivation of CaV2.2 Calcium Channels Is Modulated by the PKC Activator Phorbol 12-Myristate 13-Acetate (PMA)

CaV2.2 (N-type) voltage-gated calcium channels (Ca2+ channels) play key roles in neurons and neuroendocrine cells including the control of cellular excitability, neurotransmitter / hormone secretion, and gene expression. Calcium entry is precisely controlled by channel gating properties including multiple forms of inactivation. “Fast” voltage-dependent inactivation is relatively well-characterized and occurs over the tens-to- hundreds of milliseconds timeframe. Superimposed on this is the molecularly distinct, but poorly understood process of “slow” voltage-dependent inactivation, which develops / recovers over seconds-to-minutes. Protein kinases can modulate “slow” inactivation of sodium channels, but little is known about if/how second messengers control “slow” inactivation of Ca2+ channels. We investigated this using recombinant CaV2.2 channels expressed in HEK293 cells and native CaV2 channels endogenously expressed in adrenal chromaffin cells. The PKC activator phorbol 12-myristate 13-acetate (PMA) dramatically prolonged recovery from “slow” inactivation, but an inactive control (4α-PMA) had no effect. This effect of PMA was prevented by calphostin C, which targets the C1-domain on PKC, but only partially reduced by inhibitors that target the catalytic domain of PKC. The subtype of the channel β-subunit altered the kinetics of inactivation but not the magnitude of slowing produced by PMA. Intracellular GDP-β-S reduced the effect of PMA suggesting a role for G proteins in modulating “slow” inactivation. We postulate that the kinetics of recovery from “slow” inactivation could provide a molecular memory of recent cellular activity and help control CaV2 channel availability, electrical excitability, and neurotransmission in the seconds-to-minutes timeframe.
OFDM-Aided Differential Space–Time Shift Keying Using Iterative Soft Multiple-Symbol Differential Sphere Decoding

Soft-decision multiple-symbol differential sphere decoding (MSDSD) is proposed for orthogonal frequency-division multiplexing (OFDM)-aided differential space-time shift keying (DSTSK)-aided transmission over frequency-selective channels. Specifically, the DSTSK signaling blocks are generated by the channel-encoded source information and the space-time (ST) blocks are appropriately mapped to a number of OFDM subcarriers. After OFDM demodulation, the DSTSK signal is noncoherently detected by our soft-decision MSDSD detector. A novel soft-decision MSDSD detector is designed, and the associated decision rule is derived for the DSTSK scheme. Our simulation results demonstrate that an SNR reduction of 2 dB is achieved by the proposed scheme using an MSDSD window size of Nw = 4 over the conventional soft-decision-aided differential detection benchmarker, while communicating over dispersive channels and dispensing with channel estimation (CE).
Ebenezer Howard: The Genesis of a Town Planning Movement

Abstract Nineteenth century communitarian activity was to many a search for forms of community that rested on cooperation, fraternity, and economic progress. First viewed as a response to the excesses of the capitalist order and in particular the inhumanity of the early factory system, communitarianism was, toward the end of the century, considered an alternative to the rapid rise of the industrial city. Ebenezer Howard, who was personally attracted to the variety and vitality of the metropolis, began to believe in the 1880's that its immensity, incurable physical and social problems, and divorce from nature proscribed the symbiotic relationships needed for individual fulfillment and societal progress. He sought to invent a new type of human settlement whose size, scale, and planned order would lead to development of rational communities for an industrial age. His vision of community combined a nineteenth century enlightened view of human nature and needs with an anticipation of twentieth century technolo.
Non-hormonal topical treatment of vulvovaginal atrophy: an up-to-date overview

ABSTRACT Vulvovaginal atrophy-related symptoms exert a negative impact on the quality of life of up to 50% of postmenopausal women. Many of them decline to use topical vaginal estrogen, which is the standard effective therapy, due to the adverse publicity over recent years, and seek for alternatives. Further, there are no safety studies to support the use of topical vaginal estrogen in breast cancer survivors, and it is considered as contraindicated by many health-care professionals. Vaginal moisturizers and lubricants as well as regular sexual activity may be helpful to such women. Vaginal moisturizers may have an equivalent efficacy to topical vaginal estrogen and should be offered to women wishing to avoid the use of hormonal therapy. Lubricants are usually used during sexual intercourse to provide temporary relief from vaginal dryness and dyspareunia; however, they have no long-term therapeutic effects. We provide in this systematic review up-to-date information, for women and health-care professionals, about the use, safety and efficacy of the available vaginal moisturizers and lubricants.
Memory representations underlying motor commands used during manipulation of common and novel objects.

1. While subjects lifted a variety of commonly handled objects of different shapes, weights, and densities, the isometric vertical lifting force opposing the object's weight was recorded from an analog weight scale, which was instrumented with high-stiffness strain gauge transducers. 2. The force output was scaled differently for the various objects from the first lift, before sensory information related to the object's weight was available. The force output was successfully specified from information in memory related to the weight of common objects, because only small changes in the force-rate profiles occurred across 10 consecutive lifts. This information was retrieved during a process related to visual identification of the target object. 3. The amount of practice necessary to appropriately scale the vertical lifting and grip (pinch) force was also studied when novel objects (equipped with force transducers at the grip surfaces) of different densities were encountered. The mass of a test object that subjects had not seen previously was adjusted to either 300 or 1,000 g by inserting an appropriate mass in the object's base without altering its appearance. This resulted in either a density that was in the range of most common objects (1.2 kg/l) or a density that was unusually high (4.0 kg/l). 4. Low vertical-lifting and grip-force rates were used initially with the high-density object, as if a lighter object had been expected. However, within the first few trials, the duration of the loading phase (period of isometric force increase before lift-off) was reduced by nearly 50% and the employed force-rate profiles were targeted for the weight of the object. (ABSTRACT TRUNCATED AT 250 WORDS)
Fast direction-aware proximity for graph mining

In this paper we study asymmetric proximity measures on directed graphs, which quantify the relationships between two nodes or two groups of nodes. The measures are useful in several graph mining tasks, including clustering, link prediction and connection subgraph discovery. Our proximity measure is based on the conceptof escape probability. This way, we strive to summarize the multiple facets of nodes-proximity, while avoiding some of the pitfalls to which alternative proximity measures are susceptible. A unique feature of the measures is accounting for the underlying directional information. We put a special emphasis on computational efficiency, and develop fast solutions that are applicable in several settings. Our experimental study shows the usefulness of our proposed direction-aware proximity method for several applications, and that our algorithms achieve a significant speedup (up to 50,000x) over straight forward implementations.
Lived Experiences of Educational Leaders in Iranian Medical Education System: A Qualitative Study

Introduction: High quality educational systems are necessary for sustainable development and responding to the needs of society. In the recent decades, concerns have increased on the quality of education and competency of graduates. Since graduates of medical education are directly involved with the health of society, the quality of this system is of high importance. Investigation in the lived experience of educational leaders in the medical education systems can help to promote its quality. The present research examines this issue in Iran. Methodology: The study was done using content-analysis qualitative approach and semi-structured interviews. The participants included 26 authorities including university chancellors and vice-chancellors, ministry heads and deputies, deans of medical and basic sciences departments, education expert, graduates, and students of medical fields. Sampling was done using purposive snowball method. Data were analyzed using conventional content analysis. Findings: Five main categories and 14 sub-categories were extracted from data analysis including: quantity-orientation, ambiguity in the trainings, unsuitable educational environment, personalization of the educational management, and ineffective interpersonal relationship. The final theme was identified as “Education in shadow”. Conclusion: Personalization and inclusion of personal preferences in management styles, lack of suitable grounds, ambiguity in the structure and process of education has pushed medical education toward shadows and it is not the first priority; this can lead to incompetency of medical science graduates.
Postnatal Depression among Rural Women in South India: Do Socio-Demographic, Obstetric and Pregnancy Outcome Have a Role to Play?

Introduction Postnatal depression (PND) is one of the most common psychopathology and is considered as a serious public health issue because of its devastating effects on mother, family, and infant or the child. Objective To elicit socio-demographic, obstetric and pregnancy outcome predictors of Postnatal Depression (PND) among rural postnatal women in Karnataka state, India. Design Hospital based analytical cross sectional study Setting A rural tertiary care hospital of Mandya District, Karnataka state, India. Sample PND prevalence based estimated sample of 102 women who came for postnatal follow up from 4th to 10th week of lactation. Method Study participants were interviewed using validated kannada version of Edinburgh Postnatal Depression Scale (EPDS). Cut-off score of ≥13 was used as high risk of PND. The percentage of women at risk of PND was estimated, and differences according to socio-demographic, obstetric and pregnancy outcome were described. Logistic regression was applied to identify the independent predictors of PND risk. Main Outcome Measures Prevalence, Odds ratio (OR) and adjusted (adj) OR of PND Results Prevalence of PND was 31.4% (95% CI 22.7–41.4%). PND showed significant (P<0.05) association with joint family, working women, non-farmer husbands, poverty, female baby and pregnancy complications or known medical illness. In binomial logistic regression poverty (adjOR: 11.95, 95% CI:1.36–105), birth of female baby (adjOR: 3.6, 95% CI:1.26–10.23) and pregnancy complications or known medical illness (adjOR: 17.4, 95% CI:2.5–121.2) remained as independent predictors of PND. Conclusion Risk of PND among rural postnatal women was high (31.4%). Birth of female baby, poverty and complications in pregnancy or known medical illness could predict the high risk of PND. PND screening should be an integral part of postnatal care. Capacity building of grass root level workers and feasibility trials for screening PND by them are needed.
Proteolytic cleavage and cell wall anchoring at the LPXTG motif of surface proteins in Gram‐positive bacteria

Many surface proteins are thought to be anchored to the cell wall of Gram‐positive bacteria via their C‐terminus. Cell wall anchoring requires a specific sorting signal, normally located at the predicted C‐terminus of surface proteins. Here we show that when placed into the middle of a polypeptide chain, the sorting signal causes the specific cleavage of the precursor as well as the cell wall anchoring of its N‐ terminal fragment, while the C‐terminal fragment remains within the cytoplasm. N‐terminal sequencing of the C‐terminal cleavage fragment suggests that the cleavage site is located between threonine (T) and glycine (G) of the LPXTG motif, the signature sequence of cell wall sorting signals. All surface proteins harbouring an LPXTG sequence motif may therefore be cleaved and anchored by a universal mechanism. We also propose a novel hypothesis for the cell wall linkage of surface proteins in Gram‐positive bacteria.
Nonfamily Living and the Erosion of Traditional Family Orientations Among Young Adults

Young adults in recent cohorts have been leaving the parental home earlier and marrying later now than they did several decades ago resulting in an increased period of independent living. This paper explores the consequences of time spent in non-family living using data from the [U.S.] National Longitudinal Surveys of Young Men and Young Women. We expect that experience in living away from home prior to marriage will cause young adults to change their attitudes values plans and expectations and move them away from a traditional family orientation. The authors find evidence to support this hypothesis in the case of young women. "Those who lived independently became more likely to plan for employment lowered their expected family size became more accepting of employment of mothers and more non-traditional on sex roles in the family than those who lived with their parents. Non-family living had much weaker effects on young men in the few tests that we could perform for them. The paper also addresses the conditions under which living away increases individualism and it discusses the implications of these findings. " (EXCERPT)
Model-based clustering with Hidden Markov Model regression for time series with regime changes

This paper introduces a novel model-based clustering approach for clustering time series which present changes in regime. It consists of a mixture of polynomial regressions governed by hidden Markov chains. The underlying hidden process for each cluster activates successively several polynomial regimes during time. The parameter estimation is performed by the maximum likelihood method through a dedicated Expectation-Maximization (EM) algorithm. The proposed approach is evaluated using simulated time series and real-world time series issued from a railway diagnosis application. Comparisons with existing approaches for time series clustering, including the stand EM for Gaussian mixtures, K-means clustering, the standard mixture of regression models and mixture of Hidden Markov Models, demonstrate the effectiveness of the proposed approach.
Spatial pattern completion deficits in older adults

Aging may have an impact on the CA3 autoassociative network of the hippocampus, posited by computational models as supporting pattern completion. Twenty-five young (YAs) and 25 older adults (OAs) performed a spatial pattern completion task using a computerized navigational paradigm analogous to a rodent pattern completion task reliant on the CA3. Participants identified a previously seen goal location, and the availability of distal cues in the environment was manipulated such that 0, 2, or 4 cues were missing. Performance in both groups declined as a function of decreased cue availability. However, controlling for age differences in task performance during a pre-experimental baseline task, OAs performed equivalently to YAs when all cues were available, but worse than YAs as the number of cues decreased. These findings suggest spatial pattern completion may be impaired in OAs. We discuss these findings in the context of a growing body of literature suggesting age-related imbalances in pattern separation vs. pattern completion.
Lower bounds for embedding edit distance into normed spaces

1 In t roduc t ion The edit distance (also called Levenshtein metric) between two strings is the minimum number of operations (insertions, deletions and character substitutions) needed to transform one string into another. This distance is of key importance in computational biology, as well as text processing and other areas. Algorithms for problems involving this metric have been extensively investigated. In particular, the quadratic-time dynamic programming algorithm for computing the edit distance between two strings is one of the most investigated and used algorithms in computational biology. Recently, a new approach to problems involving edit distance has been proposed. Its basic component is construction of a mapping ff (called an embedding), which maps any string s into a vector ff(s) E ~d, so that for any pair of strings s, s', the Ip distance IIf(s)-f(s')lip is approximately equal to the edit distance between s and s ~. The approximation factor is called distortion of the embedding f. A low-distortion embedding of edit distance into lp norm would be very useful, for the following reasons: