Miracle-dz/UniFAR-FTUs huggingface dataset:
Fairness vs. Performance in Rel-13 LTE Licensed Assisted Access.pdf

Wireless spectrum being a valuable resource, a large number of both non-profit and for-profit users rely on its unlicensed parts, usually to provide some sort of local area wireless coverage. When the cellular vendors and service providers expressed interest in the unlicensed spectrum, the incumbent community started to fear that the new technology would not respect the existing users. And although members of the incumbent community strongly influenced the design of licensed assisted access (LAA) in 3GPP, the fear has not dispersed yet. Representing a vendor with stakes in both communities, we attempt to disperse the fear by providing insight on the question of fairness and performance of LAA, openly discussing why it should generate less interference than WiFi and why it could be otherwise. We augment the discussion with insightful simulations, looking how detailed parameters of the channel access mechanism influence LAA's fairness and performance. Our investigations show that in common scenarios LAA is a fair neighbor to WiFi as is, and even in an extreme scenario only small adjustments to the channel access mechanism are needed to achieve the same outcome.
An efficient grasp pose detection method based on Point-PN

Grasp pose detection is crucial in robotics and automation, but generating reliable and humanoid grasps in unstructured environments remains a challenge. Deep learning neural networks have gained attention in computer vision, leading to the development of grasp detection methods. Existing methods generate multiple potential grasp poses, but in practical applications, only one suitable grasp position is typically chosen, resulting in wasted resources and decreased effectiveness. Moreover, these methods often suffer from computational overhead. In this paper, we propose an efficient grasp pose detection method based on Point-PN to solve these problems. We are able to generate a single optimal grasp pose for objects in the scene by decoupling the grasp pose prediction task into subtasks of grasp approach vector, grasp rotation angle, and grasp depth, and evaluating the pose quality using grasp confidence scores. Additionally, We introduce a multi-structure network that utilizes Point-PN as the network backbone, enabling efficient learning of point cloud features and reducing training costs and resource consumption. For our network, we proposed a joint loss function in order to better adapt to the various grasp pose prediction subtasks. Experimental results demonstrate significant achievements in network evaluation and real robot experiments.
Fast Active Appearance Model Search Using Canonical Correlation Analysis

A fast AAM search algorithm based on canonical correlation analysis (CCA-AAM) is introduced. It efficiently models the dependency between texture residuals and model parameters during search. Experiments show that CCA-AAMs, while requiring similar implementation effort, consistently outperform standard search with regard to convergence speed by a factor of four
Reactive Extraction of Propionic Acid Using Tri-N-butyl Phosphate in Petroleum Ether: Equilibrium Study

In present paper, the recovery of propionic acid from aqueous phase by reactive extraction was studied using tri-n-butyl phosphate (TBP) in petroleum ether. Extraction using pure diluent was found to be poor. Using the mixture of extractant-diluent the extraction was significantly improved. Results were presented in terms of distribution coefficient, equilibrium complexation constant, loading ratio and extraction efficiency. Propionic acid and TBP were found to form ( = 1:1) complex with no overloading.
Adoption of media by European scientists for the creation of scientific transmedia storytelling

The purpose of this paper is to show a research plan on the adoption of user-generated media for the creation of scientific transmedia storytelling. The transmedia universe, currently becoming one of the most widely used generalist content dissemination strategies, has hardly any previous experiences in science communication. Its potential is enormous and to integrate it the scientist assumes a participant and active role in the transfer of knowledge to the society, spreading its work strategically by all communication media available. When it is time to study the role of the European scientist in this transmedia context, the first problem we encountered is its own implication. For this purpose, this study is based on the Unified Theory of Acceptance and Use of Technologies (UTAUT) model, which proposes that the intention to adopt technologies and the real adoption are positively influenced by the performance expectancy and negatively by the effort expectancy. We will investigate the current degree of media use through a questionnaire and will develop a group experiment with stimuli, to test the causality of the variables. The final objective of the research will be to know the effect of the variables on the actual use of the media and potentially to open new ways in scientific communication towards the scientific transmedia storytelling, as part of the work of the researchers, to reach a greater amount of public access to scientific knowledge.
Research on the Guidance of Emotion Generation Based on Adversarial Networks on the Positive Mentality of College Students

In recent years, with the increasing pressure of college students' study and life scientific research, the anxiety about the future and the phenomenon of psychological and behavioral problems are also increasing, and less smiling expression appears on students' faces. Research shows that smiling expression has a great guiding effect on students' relieving pressure. Therefore, the accurate reproduction of students' smiling faces is of great significance to help solve students' mental health problems, and has a wide application prospect. Based on this phenomenon, this paper uses an improved GANimation network to generate smiley faces to help students regain a positive attitude. The network mainly adds original image training to the generator training process, increases cyclic consistency loss on the basis of generating adversarial networks, and improves by replacing ordinary convolution with deep separable convolution. 200,000 preprocessed facial expressions in celebA dataset were selected for training. The test results show that, under the premise that the model is lower than the same type network in terms of computation and parameters, the smiling expression images have the characteristics of high resolution, high background retention, rich texture, and high restoration degree. Therefore, it can be concluded that: The trained smile expression can guide students to have a positive mental state to deal with the stress and anxiety of life.
Azathioprine versus mycophenolate mofetil for long-term immunosuppression in lupus nephritis: results from the MAINTAIN Nephritis Trial

Background Long-term immunosuppressive treatment does not efficiently prevent relapses of lupus nephritis (LN). This investigator-initiated randomised trial tested whether mycophenolate mofetil (MMF) was superior to azathioprine (AZA) as maintenance treatment. Methods A total of 105 patients with lupus with proliferative LN were included. All received three daily intravenous pulses of 750 mg methylprednisolone, followed by oral glucocorticoids and six fortnightly cyclophosphamide intravenous pulses of 500 mg. Based on randomisation performed at baseline, AZA (target dose: 2 mg/kg/day) or MMF (target dose: 2 g/day) was given at week 12. Analyses were by intent to treat. Time to renal flare was the primary end point. Mean (SD) follow-up of the intent-to-treat population was 48 (14) months. Results The baseline clinical, biological and pathological characteristics of patients allocated to AZA or MMF did not differ. Renal flares were observed in 13 (25%) AZA-treated and 10 (19%) MMF-treated patients. Time to renal flare, to severe systemic flare, to benign flare and to renal remission did not statistically differ. Over a 3-year period, 24 h proteinuria, serum creatinine, serum albumin, serum C3, haemoglobin and global disease activity scores improved similarly in both groups. Doubling of serum creatinine occurred in four AZA-treated and three MMF-treated patients. Adverse events did not differ between the groups except for haematological cytopenias, which were statistically more frequent in the AZA group (p=0.03) but led only one patient to drop out. Conclusions Fewer renal flares were observed in patients receiving MMF but the difference did not reach statistical significance.
Phosphorylation of Ezrin-Radixin-Moesin-binding Phosphoprotein 50 (EBP50) by Akt Promotes Stability and Mitogenic Function of S-phase Kinase-associated Protein-2 (Skp2)*

Background: The PDZ scaffolding protein EBP50 promotes Akt-dependent cell proliferation through the S-phase kinase associated protein-2 Skp2. Results: Akt phosphorylates threonine 156 of EBP50, allosterically promoting the binding of Skp2 to the first PDZ domain of EBP50. Conclusion: The interaction with EBP50 regulates the localization and stability of Skp2 and promotes cell proliferation. Significance: These studies define a regulatory mechanism contributing to Akt-dependent cell proliferation. The regulation of the cell cycle by the ubiquitin-proteasome system is dependent on the activity of E3 ligases. Skp2 (S-phase kinase associated protein-2) is the substrate recognition subunit of the E3 ligase that ubiquitylates the cell cycle inhibitors p21cip1 and p27kip1 thus promoting cell cycle progression. Increased expression of Skp2 is frequently observed in diseases characterized by excessive cell proliferation, such as cancer and neointima hyperplasia. The stability and cellular localization of Skp2 are regulated by Akt, but the molecular mechanisms underlying these effects remain only partly understood. The scaffolding protein Ezrin-Binding Phosphoprotein of 50 kDa (EBP50) contains two PDZ domains and plays a critical role in the development of neointimal hyperplasia. Here we report that EBP50 directly binds Skp2 via its first PDZ domain. Moreover, EBP50 is phosphorylated by Akt on Thr-156 within the second PDZ domain, an event that allosterically promotes binding to Skp2. The interaction with EBP50 causes cytoplasmic localization of Skp2, increases Skp2 stability and promotes proliferation of primary vascular smooth muscle cells. Collectively, these studies define a novel regulatory mechanism contributing to aberrant cell growth and highlight the importance of scaffolding function of EBP50 in Akt-dependent cell proliferation.
gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development

The oncogene GLI is amplified and expressed in some cases of human malignant glioma and undifferentiated childhood sarcoma a and is the prototype for a gene family characterized by a highly conserved set of five tandem zinc fingers and a consensus cysteine‐histidine link. This zinc finger motif has been shown to bind DNA with sequence specificity and may mediate transcriptional regulation. Since GLI is expressed in embryonal carcinoma cell lines but not in most normal adult tissues and shows significant sequence similarity within its zinc finger domain to cubitus interruptus dominant (ciD), a Drosophila segmentation gene known to be important in the morphogenesis of the posterior portion of each larval segment, we established the temporal and tissue expression patterns of the mouse homologue of human GLI in day 10 through 18 mouse embryos with Northern blotting, reverse transcriptase coupled PCR, and in situ hybridization. gli transcripts were demonstrated on days 10 through 18 of mouse embryonic development as well as in normal adult uterus, brain, testis, and limb. Tissue expression of gli during gestation was demonstrated in Meckel's precartilage mesenchyme, the basis occipitus, rib mesenchymal condensations, primordial vertebral bodies, digital mesenchymal condensations in forefoot and hindfoot plates, the ependymal layer of the spnal cord, and the mesoderm of the gastrointestinal tract. Expression persisted throughout gestation in developing bone and cartilage of the extremities, the ribs, and the vertebral bodies, as well as the gastrointestinal tract mesoderm. These findings support a role for gli family genes in normal craniofacial and digital development in mammals first suggested by the demonstration of translocation breakpoints within the GLI3 gene in families with the Greig cephalopolysyndactyly syndrome and subsequently by reduced gli3 expression in the mouse mutant extra toes. It is surprising that a single gene would be expressed in such a wide range of mesenchymal structures. © 1993 wiley‐Liss, Inc.
Presence of Cyclic Nucleotide Phosphodiesterases PDE1A, Existing as a Stable Complex with Calmodulin, and PDE3A in Human Spermatozoa1

Abstract Mammalian sperm motility, capacitation, and the acrosome reaction are regulated by signal transduction systems involving cAMP as a second messenger. Levels of cAMP are controlled by two key enzymes, adenylyl cyclase and phosphodiesterases (PDEs), the latter being involved in cAMP degradation. Calmodulin-dependent PDE (PDE1) and cAMP-specific PDE (PDE4) activities were previously identified in spermatozoa via the use of specific inhibitors. Here we report that human sperm PDEs are associated with the plasma membrane (50%–60%) as well as with the particulate fraction (30%–50%) and have more affinity for cAMP than cGMP. Immunocytochemical data indicated that PDE1A, a variant of PDE1, is localized on the equatorial segment of the sperm head as well as on the mid and principal pieces of the flagellum, and that PDE3A is found on the postacrosomal segment of the sperm head. Immunoblotting confirmed the presence of PDE1A and PDE3A isoforms in spermatozoa. Milrinone, a PDE3 inhibitor, increased intracellular levels of cAMP by about 15% but did not affect sperm functions, possibly because PDE3 represents only a small proportion of the sperm total PDE activity (10% and 25% in Triton X-100 soluble and particulate fractions, respectively). PDE1A activity in whole sperm extract or after partial purification by anion-exchange chromatography was not stimulated by calcium + calmodulin. Results obtained with electrophoresis in native conditions indicated that calmodulin is tightly bound to PDE1A. Incubation with EGTA + EDTA, trifluoperazine, or urea did not dissociate the PDE1A-calmodulin complex. These results suggest that PDE1A is permanently activated in human spermatozoa.
New Implications on Genomic Adaptation Derived from the Helicobacter pylori Genome Comparison

Background Helicobacter pylori has a reduced genome and lives in a tough environment for long-term persistence. It evolved with its particular characteristics for biological adaptation. Because several H. pylori genome sequences are available, comparative analysis could help to better understand genomic adaptation of this particular bacterium. Principal Findings We analyzed nine H. pylori genomes with emphasis on microevolution from a different perspective. Inversion was an important factor to shape the genome structure. Illegitimate recombination not only led to genomic inversion but also inverted fragment duplication, both of which contributed to the creation of new genes and gene family, and further, homological recombination contributed to events of inversion. Based on the information of genomic rearrangement, the first genome scaffold structure of H. pylori last common ancestor was produced. The core genome consists of 1186 genes, of which 22 genes could particularly adapt to human stomach niche. H. pylori contains high proportion of pseudogenes whose genesis was principally caused by homopolynucleotide (HPN) mutations. Such mutations are reversible and facilitate the control of gene expression through the change of DNA structure. The reversible mutations and a quasi-panmictic feature could allow such genes or gene fragments frequently transferred within or between populations. Hence, pseudogenes could be a reservoir of adaptation materials and the HPN mutations could be favorable to H. pylori adaptation, leading to HPN accumulation on the genomes, which corresponds to a special feature of Helicobacter species: extremely high HPN composition of genome. Conclusion Our research demonstrated that both genome content and structure of H. pylori have been highly adapted to its particular life style.
Formation and Tuning of Frequency Comb-Like Signal in Photonic Crystal Coupled-Cavities Waveguides

We consider two-dimensional photonic crystal waveguide with coupled cavity system in the waveguide channel for the purpose of frequency comb-like signal formation in the optical communication wavelengths. Coupled cavity system configuration change is numerically investigated for tuning of output signal. Comb-like signal bandwidth and frequency shift varying are shown for different configurations of the waveguide channel.
On the use of melodic patterns as prosodic correlates of emotion in Spanish

This paper presents an acoustic and perceptual analysis of the use of melodic patterns as prosodic correlates of the expression of emotional states in Spanish. The data of the acoustic analysis of a corpus of neutral and emotional declarative sentences in Spanish are presented first, showing that emotional utterances are frequently closed by a ‘rise-fall’ pattern that is not used in neutral speech. However, the results of the perceptual experiment carried out to test the perceptual relevance of this pattern for the identification of emotions in speech seem to indicate that, although it does contribute to recognize a utterance as emotional, its use is not a sufficient cue by itself.
Stent-induced Restenosis in the Swine Coronary Artery Is Inhibited by a Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor, TKI963

Activities of vascular smooth muscle cells (SMCs) such as proliferation, migration, and matrix production contribute to restenosis following clinical interventions of angioplasty and stent placement. Because activation of platelet-derived growth factor (PDGF)-receptor tyrosine kinase (PDGFr-TK) influences these processes and promotes restenosis, TKI963, an inhibitor of the PDGFr-TK was discovered, and its efficacy was evaluated in blocking stent-induced restenosis as analyzed by intravascular ultrasound (IVUS). TKI963, a low-molecular-weight compound, inhibited the cell-free PDGF&bgr;r-TK with a Ki value of 56 ± 14 n M. TKI963 also inhibited PDGF-dependent events in human aortic SMCs (e.g., in situ PDGFr autophosphorylation, mitogenesis, chemotaxis, and collagen production with median inhibitory concentration values of approximately 300 n M) without affecting the activity of a series of membrane receptor tyrosine kinases and intracellular serine/threonine kinases. In vivo, stent-induced restenosis in the swine coronary artery was reduced by oral administration of TKI963 (1.25, 2.5, and 5 mg/kg BID, for 28 days). Late lumen cross-sectional area (CSA) loss, plaque CSA growth, and plaque volume in the stent determined by IVUS were dose-relatedly decreased (33–62% at 1.25 mg/kg BID to 66–92% at 5 mg/kg BID, depending on the parameter) compared with controls. TKI963 treatment of ≤1 week following stent placement had no effect on the prevention of restenosis. TKI963, a selective, orally bioavailable inhibitor of the PDGFr-TK, dose-relatedly reduced stent-induced restenosis and did so by inhibiting PDGF-dependent activities that occur as late events following stent placement.
Interfacing a Flying Robot with OpenCV

This research work is carried out to satisfy the requirements of developing industries. As per our today's requirements, safety plays a vital role in all industries. Also, a cost-effective system is required to maintain safety around our workplaces. By considering all the factors in mind, a flying robot system is made to instruct the employees to safeguard themselves by identifying near misses in the industries. The main aim of the work is to design a flying robot system with a camera to identify persons without safety equipment. So, every half an hour the images will be automatically captured by the surveillance drone and sent to the ground station which is operated by the OpenCV library for tracking objects like monitoring the crowd, detecting fire, and near misses to safeguard the employees from accidents. Here, a functional prototype is developed to achieve the goals and implement it in industrial applications.
Agyaat: mutual anonymity over structured P2P networks

Purpose – To provide mutual anonymity over traditionally un‐anonymous Distributed Hash Tables (DHT) based Peer‐to‐Peer overlay networks, while maintaining the desired scalability and guaranteed lookup properties of the DHTs.Design/methodology/approach – Agyaat uses a novel hybrid‐overlay design, a fully decentralized topology without any trusted proxies. It anonymizes both the querying and responding peers through the use of unstructured topologies, called clouds, which are added onto the structured overlays. In addition, it regulates the cloud topologies to ensure the guaranteed location of data and scalability of routing. A unique characteristic of the design is the ability of users to tradeoff between desired anonymity and performance. The paper presents a thorough performance and anonymity analysis of the system, and also analyzes few anonymity compromising attacks and countermeasures.Findings – The results indicate that Agyaat is able to provide mutual anonymity while maintaining the scalability of l.
Heterogeneous computing with accelerators: an overview with examples

Accelerator-based platforms are heterogeneous in nature, yet most applications avoid heterogeneity, and focus on acceleration alone. Platform-level heterogeneity can bring significant performance improvement, as it essentially means using additional resources for the same computation. But is the performance gained using these additional resources worth the effort to program and deploy heterogeneous applications? In this work, we present a taxonomy of the existing programming models and tools available for heterogeneous computing with accelerators, and give examples of systems fitting different classes. We further provide guidelines for efficiently navigating this landscape in the search for a suitable tool for designing and deploying a new application.
Planning Graph as a (Dynamic) CSP: Exploiting EBL, DDB and other CSP Search Techniques in Graphplan

This paper reviews the connections between Graphplan's planning-graph and the dynamic constraint satisfaction problem and motivates the need for adapting CSP search techniques to the Graphplan algorithm. It then describes how explanation based learning, dependency directed backtracking, dynamic variable ordering, forward checking, sticky values and random-restart search strategies can be adapted to Graphplan. Empirical results are provided to demonstrate that these augmentations improve Graphplan's performance significantly (up to 1000x speedups) on several benchmark problems. Special attention is paid to the explanation-based learning and dependency directed backtracking techniques as they are empirically found to be most useful in improving the performance of Graphplan.
Path planning based on Genetic Algorithms and the Monte-Carlo method to avoid aerial vehicle collisions under uncertainties

This paper presents a collision-free path planning method for an aerial vehicle sharing airspace with other aerial vehicles. It is based on grid models and genetic algorithms to find safe trajectories. Monte-Carlo method is used to evaluate the best predicted trajectories considering different sources of uncertainty such as the wind, the inaccuracies in the vehicle model and limitations of on-board sensors and control system.