Miracle-dz/UniFAR-FTUs huggingface dataset:
The development of a clinical management algorithm for early physical activity and mobilization of critically ill patients: synthesis of evidence and expert opinion and its translation into practice

Objective: To facilitate knowledge synthesis and implementation of evidence supporting early physical activity and mobilization of adult patients in the intensive care unit and its translation into practice, we developed an evidence-based clinical management algorithm. Methods: Twenty-eight draft algorithm statements extracted from the extant literature by the primary research team were verified and rated by scientist clinicians (n = 7) in an electronic three round Delphi process. Algorithm statements which reached a priori defined consensus – semi-interquartile range <0.5 – were collated into the algorithm. Results: The draft algorithm statements were edited and six additional statements were formulated. The 34 statements related to assessment and treatment were grouped into three categories. Category A included statements for unconscious critically ill patients; Category B included statements for stable and cooperative critically ill patients, and Category C included statements related to stable patients with prolonged critical illness. While panellists reached consensus on the ratings of 94% (32/34) of the algorithm statements, only 50% (17/34) of the statements were rated essential. Conclusion: The evidence-based clinical management algorithm developed through an established Delphi process of consensus by an international inter-professional panel provides the clinician with a synthesis of current evidence and clinical expert opinion. This framework can be used to facilitate clinical decision making within the context of a given patient. The next step is to determine the clinical utility of this working algorithm.
A winding function-based model of air-gap eccentricity in saturated induction motors

This paper set out a new modeling technique of air-gap eccentricity in induction motors (IMs) taking into account teeth saturation due to the local air-gap flux concentration. The approach is based on the inclusion of the magnetic saturation into the analytical model by a fictive permeance variation. Besides that, it supposes that, in air-gap nonuniformity conditions, the well-known saturation factor must be updated in function of the spatial-dependant air-gap length. The 2D-modified winding function approach (2D-MWFA) is utilized to get the inductance formalism while assuming a linear rise of the saturation factor with respect to the air-gap length in a particular circumferential region. We show that the proposed model yields more reasonable results by confirming that the magnetic saturation effect reduces the asymmetry of the air-gap flux distribution due to the eccentricity. Furthermore, we highlight this effect by inspecting the shapes of the calculated inductances and making them ready for a full dynamic simulation in sense of multiple coupled circuit model (MCCM).
The Human Adenovirus Type 5 E1B 55-Kilodalton Protein Is Phosphorylated by Protein Kinase CK2

ABSTRACT The human adenovirus type 5 (HAdV5) early region 1B 55-kDa protein (E1B-55K) is a multifunctional phosphoprotein playing several critical roles during adenoviral productive infection, e.g., degradation of host cell proteins, viral late mRNA export, and inhibition of p53-mediated transcription. Many of these functions are apparently regulated at least in part by the phosphorylation of E1B-55K occurring at a stretch of amino acids resembling a potential CK2 consensus phosphorylation motif. We therefore investigated the potential role of CK2 phosphorylation upon E1B-55K during adenoviral infection. A phosphonegative E1B-55K mutant showed severely reduced virus progeny production, although viral early, late, and structural protein levels and viral DNA replication were not obviously affected. Binding studies revealed an interaction between the CK2α catalytic subunit and wild-type E1B-55K, which is severely impaired in the phosphonegative E1B mutant. In addition, in situ the α-catalytic subunit is redistributed into ring-like structures surrounding E1B-55K nuclear areas and distinct cytoplasmic accumulations, where a significant amount of CK2α colocalizes with E1B-55K. Furthermore, in in vitro phosphorylation assays, wild-type E1B-55K glutathione S-transferase fusion proteins were readily phosphorylated by the CK2α subunit but inefficiently phosphorylated by the CK2 holoenzyme. Addition of the CK2-specific inhibitors TBB (4,5,6,7-tetrabromobenzotriazole) and DMAT (2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole) to infected cells confirmed that CK2α binding to E1B-55K is necessary for efficient phosphorylation of E1B-55K. In summary, our data show that CK2α interacts with and phosphorylates HAdV5 E1B-55K at residues S490/491 and T495 and that these posttranslational modifications are essential for E1B-55K lytic functions.
Limitations of the Oral Trail Making Test in a Mixed Sample of Older Individuals

The utility of the Oral Trail Making Test (OTMT), a motor and visual-free alternative to the traditional Trail Making Test, was examined in 86 older (=60 years old) medical inpatients and 30 healthy controls. The OTMT-Part B evidenced a moderate correlation with the MMSE, and individuals with medical conditions that affect cognition displayed a high failure rate (more than five errors or 300+s). Moderate education effects were present for the OTMT-Part B. Thus, the current study suggests caution when employing this test and the above noted cutoffs with older medical patients or those with lower levels of education.
Prospective comparative study of computer programs used for management of warfarin.

as nearly as possible with those of the above authors, who used a range of 2-0 to 3 0, we have used 2-3 to 3-3. The ranges used by these authors are narrow, and divergence from them does not necessarily mean that anticoagulation is at a level which is either ineffective or dangerous. We followed their division into the first 26 weeks of treatment and the period, if any, after that point. The results are shown in the table. With the important exception of the interval between visits, our experience is not 1 Lane-Claypon JE, Starling EH. An experimental enquiry into factors which determine the growth and activity of the mammary glands. IAroc Roy Soc 1904;505-22. 2 Marcum RG, Wellings SR. Subgross pathology of the human breast: methods and initial observations. JNCI 1969;42:115-21. 3 Armstrong JS, Davies JD, Hronkova B. Backprocessing paraffin wax blocks for subgross examination. Clin Pathol 1992;45: 1116-7. 4 Faverly D, Holland R, Burgers L. An original stereomicroscopic analysis of the mammary glandular tree. Virchows Arch (Pathol Anat) 1992;421:115-9. 5 Bassler R Makromastie. In: Pathologie der Brustdruse. Berlin: Springer-Verlag. 1978: 283-97. 6 Bondeson L, Linell F, Ringberg A. Breast reductions: what to do with all the tissue specimens? Histopathology 1985;9:281-5.
Estimating verbal expressions of task and social cohesion in meetings by quantifying paralinguistic mimicry

In this paper we propose a novel method of estimating verbal expressions of task and social cohesion by quantifying the dynamic alignment of nonverbal behaviors in speech. As team cohesion has been linked to team effectiveness and productivity, automatically estimating team cohesion can be a useful tool for assessing meeting quality and broader team functioning. In total, more than 20 hours of business meetings (3-8 people) were recorded and annotated for behavioral indicators of group cohesion, distinguishing between social and task cohesion. We hypothesized that behaviors commonly referred to as mimicry can be indicative of verbal expressions of social and task cohesion. Where most prior work targets mimicry of dyads, we investigated the effectiveness of quantifying group-level phenomena. A dynamic approach was adopted in which both the cohesion expressions and the paralinguistic mimicry were quantified on small time windows. By extracting features solely related to the alignment of paralinguistic speech behavior, we found that 2-minute high and low social cohesive regions could be classified with a 0.71 Area under the ROC curve, performing on par with the state-of-the-art where turn-taking features were used. Estimating task cohesion was more challenging, obtaining an accuracy of 0.64 AUC, outperforming the state-of-the-art. Our results suggest that our proposed methodology is successful in quantifying group-level paralinguistic mimicry. As both the state-of-the-art turn-taking features and mimicry features performed worse on estimating task cohesion, we conclude that social cohesion is more openly expressed by nonverbal vocal behavior than task cohesion.
Estimation of Irrigation Water Demand and Economic Returns of Water in Zhangye Basin

The objective of this study is to provide estimates of price elasticities of irrigation water demands in Zhangye Basin (ZB), an inland river basin in China, with the most recent data and to compare the values of marginal product (VMPs) of water to the prices of water farmers are currently paying. With a set of village and household survey data collected in 2009 and 2014, household fixed effects models are used to estimate water demand and crop production functions. The estimation results are then used to estimate price elasticities and VMPs. Results show that demands for surface water, groundwater, and conjunctive irrigation water are all in the inelastic range. The results imply that water prices may need to be increased significantly to induce sizable water savings. Another significant finding is that for a large share of the sample households, VMPs of water are higher than the prices of water. The estimated VMPs provide policy makers with some guidelines on the minimum level of water prices required to achieve any water savings among those households.
Predictors of Sleep Quality and Successful Weaning From Mechanical Ventilation Among Patients in Respiratory Care Centers

Background: Poor quality of sleep may result in more problems for patients who undergo weaning from mechanical ventilation because it could result in disabled muscle relaxation and affect the function of the respiratory muscles. Few studies have specifically investigated what factors contributed to quality of sleep and weaning outcomes. Purpose: This study investigates the predictors of quality of sleep and successful weaning from mechanical ventilation in patients at respiratory care centers. Methods: We used a cross-sectional design to recruit 94 patients who were in the process of weaning from ventilation at three respiratory care centers in a medical center in central Taiwan. A structured questionnaire was used to collect data. Disease severity during the first 24 hours after commencing the weaning process was assessed using the Acute Physiology and Chronic Health Evaluation II. Level of consciousness was evaluated using the Glasgow Coma Scale, and quality of sleep was measured using the Verran and Snyder–Halpern Sleep Scale. Stepwise multiple regression and logistic regression were used for multivariate analysis. Results: Fifty-three (56.4%) of the 94 participants successfully completed the weaning process. Participants who successfully weaned within 72 hours were younger (p = .038), had a lower level of disease severity (p < .001), and had a better quality of sleep (p = .004) than their counterparts who failed to wean. Factors including disease severity (B = −1.32), current use of hypnotic drugs (B = −10.71), and having three-to-four coexisting chronic diseases (B = −9.91) contributed negatively to quality of sleep. Factors including level of consciousness (odds ratio [OR] = 1.64), quality of sleep (OR = 1.05), disease severity (OR = 0.81), and alcohol consumption history (OR = 0.21) were found to significantly impact weaning success. Conclusions/Implications for Practice: A strong relationship was identified between disease severity and quality of sleep. Both factors are significant predictors of successful weaning from mechanical ventilation. A better understanding of the related risk factors will help improve the care provided by nurses and medical personnel to patients undergoing the weaning process.
PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection

Abstract Double strand breaks (DSBs) are one of the most toxic lesions to cells. DSB repair by the canonical non-homologous end-joining (C-EJ) pathway involves minor, if any, processing of the broken DNA-ends, whereas the initiation of DNA resection channels the broken-ends toward DNA repair pathways using various lengths of homology. Mechanisms that control the resection initiation are thus central to the regulation to the choice of DSB repair pathway. Therefore, understanding the mechanisms which regulate the initiation of DNA end-resection is of prime importance. Our findings reveal that poly(ADP-ribose) polymerase 2 (PARP2) is involved in DSBR pathway choice independently of its PAR synthesis activity. We show that PARP2 favors repair by homologous recombination (HR), single strand annealing (SSA) and alternative-end joining (A-EJ) rather than the C-EJ pathway and increases the deletion sizes at A-EJ junctions. We demonstrate that PARP2 specifically limits the accumulation of the resection barrier factor 53BP1 at DNA damage sites, allowing efficient CtIP-dependent DNA end-resection. Collectively, we have identified a new PARP2 function, independent of its PAR synthesis activity, which directs DSBs toward resection-dependent repair pathways.
Directional Visual Descriptors and Multirobot Strategies for Large‐Scale Coverage Problems

Visual coverage of large‐scale environments is a key issue for several, important application scenarios, such as large‐scale three‐dimensional (3D) reconstruction, search and rescue, and active video surveillance. In this paper, we consider a setting where a group of robots, equipped with standard cameras, must fully cover a surrounding area while minimizing associated movement costs. To address this problem, we use a descriptor for visual coverage that encodes a measure of the visual information contained in an area, based on a regular discretization of the environment in voxels. In particular, our measure of coverage is related to how much of each voxel volume is “penetrated” by the bundle of rays projected from the camera center. Crucially, our descriptor explicitly encodes the viewing direction from which the voxel is observed, which is a key element to measure coverage of visual sensors. Next, we propose an autonomous cooperative exploration approach to control robot movements. Specifically, based on our visual coverage descriptor, we define a utility function to encode the value of future moves for the robots, and we select the next move for a robot by performing a greedy maximization of such utility function. Finally, we empirically evaluate our approach in a simulation scenario based on real visual data and on widely used robotic tools (such as ROS and Stage). Experimental results show that the proposed method outperforms baseline random approaches (i.e., random, semirandom, and uncoordinated) and thus is a valid solution for visual coverage in large‐scale outdoor scenarios.
Agronomic and Biotechnological Strategies for Breeding Cultivated Garlic in Mexico

Garlic is an apomyctic diploid species (2n=2x=16) with vegetative reproduction that belongs to the Allium genus (Alliaceae), which includes onion (Allium cepa), leek (A. ampeloprasum) and shallot (A. ascalonicum) (Mc-Collum, 1987; Figliuolo et al., 2001; Ipek et al., 2003; 2005). The importance of garlic was recognized by humans at bronze era about 5000 years ago, and since these early times, has been used as food, condiment and medicine by Asians and Mediterranean (Ipek et al., 2005). World production of garlic is ranked 14th among vegetables with a total of 14.5 million ton (Trejo, 2006). In Mexico, its consumption is about 400 g per capita (Chavez, 2008), and the national production is considered low as compared to other countries such as China (80 % world production), India, Korea and the rest of the world (20 %) (FAOSTAT, 2011). Still, Mexico has a place as exporter of garlic produced mainly from the states: Zacatecas, Guanajuato, Aguascalientes, Baja California, Puebla and Sonora (Trejo, 2006). The areas in Mexico during winter 2008, dedicated to garlic were 5,085 ha with a total yield of 49,968 ton (SIAP, 2011).
Networked Control With Stochastic Scheduling

This note develops the time-delay approach to networked control systems with scheduling protocols, variable delays and variable sampling intervals. The scheduling of sensor communication is defined by a stochastic protocol. Two classes of protocols are considered. The first one is defined by an independent and identically-distributed stochastic process. The activation probability of each sensor node for this protocol is a given constant, whereas it is assumed that collisions occur with a certain probability. The resulting closed-loop system is a stochastic impulsive system with delays both in the continuous dynamics and in the reset equations, where the system matrices have stochastic parameters with Bernoulli distributions. The second scheduling protocol is defined by a discrete-time Markov chain with a known transition probability matrix taking into account collisions. The resulting closed-loop system is a Markovian jump impulsive system with delays both in the continuous dynamics and in the reset equations. Sufficient conditions for exponential mean-square stability of the resulting closed-loop system are derived via a Lyapunov-Krasovskii-based method. The efficiency of the method is illustrated on an example of a batch reactor. It is demonstrated how the time-delay approach allows treating network-induced delays larger than the sampling intervals in the presence of collisions.
Preparation and Characterization of Gastroretentive Floating Microspheres of Ofloxacin Hydrochloride

As Ofloxacin is preferably absorbed from the upper part of the gastrointestinal tract and is readily soluble in the acidic environment of the stomach, the floating microspheres of ofloxacin were formulated to develop gastroretentive formulation. These floating microspheres release the drug in the stomach and upper gastrointestinal tract and thereby improve the bioavailability. In the present study, six formulations of ofloxacin hydrochloride were prepared as floating microspheres by solvent diffusion technique using polymers such as ethyl cellulose, polyvinyl pyrrolidone K-90 and poly vinyl alcohol in different ratios. The prepared microspheres were evaluated for different physicochemical tests such as particle size, percent drug entrapment, drug content uniformity, SEM, buoyancy test, and in vitro drug release studies. The results of all the physicochemical tests of all formulations were found to be satisfactory. In vitro floatability studies revealed that most of the microspheres (52.5% to 95.5%) were floatable. The in vitro drug release was found to be in the range of 39.64 to 93.64 % at the end of 6 hours. It is concluded that these floating microspheres can be selected for the development of gastroretentive drug delivery system of ofloxacin hydrochloride for potential therapeutic uses.
Cluster Tree Based Hybrid Document SimilarityMeasure

Cluster tree based hybrid similarity measure is established to measure the hybrid similarity. In cluster tree, the hybrid similarity measure can be calculated for the random data even it may not be the co-occurred and generate different views. Different views of tree can be combined and choose the one which is significant in cost. A method is proposed to combine the multiple views. Multiple views are represented by different distance measures into a single cluster. Comparing the cluster tree based hybrid similarity with the traditional statistical methods it gives the better feasibility for intelligent based search. It helps in improving the dimensionality reduction and semantic analysis.
Extended survival of patients with persistently suppressed hepatitis B transplanted for hepatocellular carcinoma

Hepatocellular carcinoma (HCC) has become a major cause of liver‐related death and indication to liver transplantation (LT) in patients with chronic hepatitis B virus (HBV) infection following the widespread adoption of antiviral therapy with nucleos(t)ide analogs (NUCs). Yet, the long‐term outcome of patients undergoing liver transplantation for an HCC developed during effective NUC treatment is unknown.
Detection of New Bunyavirus RNA by Reverse Transcription–Loop-Mediated Isothermal Amplification

ABSTRACT Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging and epidemic infectious disease in central and northeast China. It is caused by New Bunyavirus and carries an average 12% case fatality rate. Early and rapid detection is critical for prevention and control of New Bunyavirus infection, since no vaccine or antiviral drugs are currently available, and prevention requires careful attention to control of the suspected tick vector. In this study, a simple and sensitive reverse transcription–loop-mediated isothermal amplification (RT-LAMP) assay was developed for rapid detection of New Bunyavirus. The detection limit of the RT-LAMP assay was approximately 103 50% tissue culture infective doses/ml of New Bunyavirus in culture supernatants, and no cross-reactive amplification of other viruses known to cause similar clinical manifestations was observed. The assay was further evaluated using 138 specimens from clinically suspected SFTS and 40 laboratory-proven hantavirus infection with fever and renal syndrome patients, and the assay exhibited 97% agreement compared to real-time RT-PCR and conventional RT-PCR. Using real-time RT-PCR as the diagnostic gold standard, RT-LAMP was 99% sensitive and 100% specific. The RT-LAMP assay could become a useful alternative in clinical diagnosis of SFTS caused by New Bunyavirus, especially in resource-limited hospitals or rural clinics of China.
Characterization of the divalent metal binding site of bacterial polysaccharide deacetylase using crystallography and quantum chemical calculations

Peptidoglycan deacetlyase (HP0310, HpPgdA) from the gram‐negative pathogen Helicobacter pylori, is the enzyme responsible for a peptidoglycan modification that counteracts the host immune response. In a recent study, we determined the crystallographic structure of the enzyme, which is a homo‐tetramer (Shaik et al., PloS One 2011;6:e19207). The metal‐binding site, which is essential for the enzyme's catalytic activity, is visible within the structure, but we were unable to identify the nature of the metal itself. In this study, we have obtained a higher‐resolution crystal structure of the enzyme, which shows that the ion bound is, in fact, zinc. Analysis of the structure of the four sites, one per monomer, and quantum chemical calculations of models of the site in the presence of different divalent metal ions show an intrinsic preference for zinc, but also significant flexibility of the site so that binding of other ions can eventually occur. Proteins 2014; 82:1311–1318. © 2013 Wiley Periodicals, Inc.
Maîtriser les déluges de données hétérogènes

Le traitement automatique des langues fait de plus en plus appel a de volumineux corpus textuels pour l'acquisition des connaissances. L'obstacle actuel n'est plus la disponibilite de corpus, ni meme leur taille, mais l'heterogeneite des donnees qui sont rassemblees sous ce nom. Dans cet article, nous examinons l'heterogeneite que manifestent les articles du Monde quand on les regroupe selon les rubriques de la redaction du journal. Les consequences d'une telle heterogeneite pour l'etiquetage et le parsage sont soulignees. Partant de ce constat, nous definissons la notion de "profilage de corpus" par le biais d'outils permettant d'evaluer l'homogeneite d'un corpus (sur-emploi du vocabulaire, de categories morpho-syntaxiques, ou de patrons) et l'utilisation qui peut en etre faite.