Miracle-dz/UniFAR-FTUs huggingface dataset:
Gene‐environment interaction influences attachment‐like style in mice

Attachment styles are established soon after birth and form the basis for a healthy psychological life during adulthood. Here, we investigated whether genetic background (i.e. isogenic strains: C57BL/6N and BALB/c) and parent‐of‐origin (i.e. reciprocal hybrids) epigenetic effects influence attachment‐like styles in mice. We discovered that a specific genetic and epigenetic assortment exerts a role on the development of a secure or insecure attachment‐like style. In particular, when biological mothers raise their pups, the attachment‐like style is mainly secure, independently of the genetic background. However, when foster mothers raise pups, the attachment‐like style can be either secure or insecure, depending on the particular genetic background, and this effect is paternally transmitted. Finally, we observed that secure attachment‐like in mice leads to greater sociability during adulthood, while insecure attachment‐like leads to reduced sociability. Our study sheds light on gene‐environment interactions that shape the attachment‐like style early in development and pave the way for a healthy psychological life.
An Efficient Java Implementation of the Immediate Successors Calculation

The authors present in this paper an eective Java imple- mentation of the concept immediate successors calculation. It is based on the lattice Java library, developed by K. Bertet and the Limited Ob- jects Access algorithm, proposed by C. Demko and K. Bertet (6) with Java-specific enhancements. This work was motivated by the need of an ecient tool delivering this service in an accessible and popular program- ming language for a wider research project: eBDtheque. Performances are compared and analyzed.
TRiFLe, a Program for In Silico Terminal Restriction Fragment Length Polymorphism Analysis with User-Defined Sequence Sets

ABSTRACT We describe TRiFLe, a freely accessible computer program that generates theoretical terminal restriction fragments (T-RFs) from any user-supplied sequence set tailored to a particular group of organisms, sequences from clone libraries, or sequences from specific genes. The program allows a rapid identification of the most polymorphic enzymes, creates a collection of T-RFs for the data set, and can potentially identify specific T-RFs in T-RF length polymorphism (T-RFLP) patterns by comparing theoretical and experimental results. TRiFLE was used for analyzing T-RFLP data generated for the amoA and pmoA genes. The peaks identified in the T-RFLP patterns show an overlap of ammonia- and methane-oxidizing bacteria in the metalimnion of a subtropical lake.
Household fear of deportation in Mexican‐origin families: Relation to body mass index percentiles and salivary uric acid

Fear of deportation (FOD) is a prevalent concern among mixed‐status families. Yet, our understanding of how FOD shapes human health and development is in its infancy. To begin to address this knowledge gap, we examined the relationship between household FOD, body mass index (BMI) percentiles and salivary uric acid (sUA), a biomarker related to oxidative stress/hypertension/metabolic syndrome, among 111 individuals living in Mexican‐origin families.
Compositional Construction of Approximate Abstractions of Interconnected Control Systems

We consider a compositional construction of approximate abstractions of interconnected control systems. In our framework, an abstraction acts as a substitute in the controller design process and is itself a continuous control system. The abstraction is related to the concrete control system via a so-called simulation function: a Lyapunov-like function, which is used to establish a quantitative bound between the behavior of the approximate abstraction and the concrete system. In the first part of the paper, we provide a small gain type condition that facilitates the compositional construction of an abstraction of an interconnected control system together with a simulation function from the abstractions and simulation functions of the individual subsystems. In the second part of the paper, we restrict our attention to linear control system and characterize simulation functions in terms of controlled invariant, externally stabilizable subspaces. Based on those characterizations, we propose a particular scheme to construct abstractions for linear control systems. We illustrate the compositional construction of an abstraction on an interconnected system consisting of four linear subsystems. We use the abstraction as a substitute to synthesize a controller to enforce a certain linear temporal logic specification.
Comparison of BQ123, Epoprostenol, and Verapamil as Vasodilators During Normothermic Ex Vivo Liver Machine Perfusion

Background The optimal vasodilator to avoid hepatic artery vasospasm during normothermic ex vivo liver perfusion (NEVLP) is yet to be determined. We compared safety and efficacy of BQ123 (endothelin1 antagonist), epoprostenol (prostacyclin analogue), and verapamil (calcium channel antagonist). Methods Livers from porcine heart beating donors were perfused for 3 hours and transplanted into recipient pigs. Four groups were compared: group 1, livers perfused with a dose of 1.25 mg of BQ123 at baseline and at 2 hours of perfusion; group 2, epoprostenol at a continuous infusion of 4 mg/h; group 3, verapamil 2.5 mg at baseline and at 2 hours of perfusion; group 4, no vasodilator used during ex vivo perfusion. Liver injury and function were assessed during perfusion, and daily posttransplantation until postoperative day (POD) 3. All groups were compared with a cold storage group for postoperative graft function. Results Hepatic artery flow during NEVLP was significantly higher in BQ123 compared with verapamil, epoprostenol, and no vasodilator-treated livers. Aspartate aminotransferase levels were significantly lower with BQ123 and verapamil compared with epoprostenol and control group during perfusion. Peak aspartate aminotransferase levels were lower in pigs receiving BQ123 and verapamil perfused grafts compared with epoprostenol and control group. International Normalized Ratio, alkaline phosphatase, and total bilirubin levels were lower in the BQ123 and verapamil groups compared to epoprostenol group. Cold storage group had increased markers of ischemia reperfusion injury and slower graft function recovery compared to machine perfused grafts. Conclusion The use of BQ123, epoprostenol, and verapamil during NEVLP is safe. Livers perfused with BQ123 and verapamil have higher hepatic artery flow and reduced hepatocyte injury during perfusion compared with epoprostenol. Hepatic artery flow is significantly reduced in the absence of vasodilators during NEVLP.
Supporting Security Requirements for Resource Management in Cloud Computing

We address the problem of guaranteeing security, with additional consideration on reliability and availability issues, in the management of resources in Cloud environments. We investigate and formulate different requirements that users or service providers may wish to specify. Our framework allows providers to impose restrictions on the allocations to be made to their hosts and users to express constraints on the placement of their virtual machines (VMs). User's placement constraints may impose restrictions in performing allocation to specific locations, within certain boundaries, or depending on some conditions (e.g., requiring a VM to be allocated to a different host wrt other VMs). Our approach for VM allocation goes beyond the classical (performance/cost-oriented) resource consumption to incorporate the security requirements specified by users and providers.
Muscle strength and body mass index as long-term predictors of mortality in initially healthy men.

BACKGROUND Muscle weakness, low body weight, and chronic diseases are often observed in the same people; however, the association of muscle strength with mortality, independent of disease status and body weight, has not been elucidated. The aim was to assess hand grip strength as a predictor of all-cause mortality within different levels of body mass index (BMI) in initially disease-free men. METHODS Mortality was followed prospectively over 30 years. Maximal hand grip strength tests and BMI assessments were done at baseline in 1965 to 1970. The participants were 6040 healthy men aged 45 to 68 years at baseline living on Oahu, Hawaii. RESULTS The death rates per 1000 person years were 24.6 in those with BMI <20, 18.5 in the middle BMI category, and 18.0 in those with BMI > or = 25. For grip strength tertiles, the mortality rates were 24.8 in the lowest, 18.5 in the middle, and 14.0 in the highest third. In Cox regression models, within each tertile of grip strength, BMI showed only minimal effect on mortality. In contrast, in each category of BMI there was a gradient of decreasing mortality risk with increasing grip strength. Among those with BMI <20, the adjusted relative risks (RRs) of mortality over 30 years were 1.36 (95% confidence interval 1.14-1.63) for those in the lowest third of strength at baseline, 1.27 (1.02-1.58) in the middle, and 0.92 (0.66-1.29) in the highest third. Correspondingly, for those with BMI 20-24.99, the RRs of death were 1.25 (1.08-1.45), 1.14 (1.00-1.32), and 1.0 (reference) in the lowest, middle, and highest third of grip strength, respectively. In those with BMI > or =25, the RRs were 1.39 (1.16-1.65) in the lowest, 1.27 (1.08-1.49) in the middle, and 1.14 (0.98-1.32) in the highest third of grip strength. Models were adjusted for age, education, occupation, smoking, physical activity, and body height. CONCLUSIONS In healthy middle-aged men, long-term mortality risk was associated with grip strength at baseline, independent of BMI. The possible interpretation of the finding is that early life influences on muscle strength may have long-term implications for mortality. Additionally, higher strength itself may provide greater physiologic and functional reserve that protects against mortality.
Swarm Data Mining for the Fine Structure of Thermals

Accurate thermal models can help to optimize the design of sailplanes. Theoretical models should be based on empirical evidence. However, very few measurements on the structure of thermals are published. This paper uses data mining techniques on data collected by swarms. In this case the swarm consists of the world’s best pilots in the world’s best gliders competing in a world championship at Uvalde, Texas in 2012. It is pointed out how the data collected by this swarm in the form of ICG files (i.e. GPS recordings) may be processed in order to yield the vertical speed of the air in thermals. This resulted in about 100 hours of data on thermals. From this data a model of the fine structure of thermals could be derived consisting of three components: a Gaussian representing the buoyancy, a vortex modeling entrainment and a border vortex caused by the difference in speed between the air inside the thermal and the surrounding air.
Self-supervised learning of tool affordances from 3D tool representation through parallel SOM mapping

Future humanoid robots will be expected to carry out a wide range of tasks for which they had not been originally equipped by learning new skills and adapting to their environment. A crucial requirement towards that goal is to be able to take advantage of external elements as tools to perform tasks for which their own manipulators are insufficient; the ability to autonomously learn how to use tools will render robots far more versatile and simpler to design. Motivated by this prospect, this paper proposes and evaluates an approach to allow robots to learn tool affordances based on their 3D geometry. To this end, we apply tool-pose descriptors to represent tools combined with the way in which they are grasped, and affordance vectors to represent the effect tool-poses achieve in function of the action performed. This way, tool affordance learning consists in determining the mapping between these 2 representations, which is achieved in 2 steps. First, the dimensionality of both representations is reduced by unsupervisedly mapping them onto respective Self-Organizing Maps (SOMs). Then, the mapping between the neurons in the tool-pose SOM and the neurons in the affordance SOM for pairs of tool-poses and their corresponding affordance vectors, respectively, is learned with a neural based regression model. This method enables the robot to accurately predict the effect of its actions using tools, and thus to select the best action for a given goal, even with tools not seen on the learning phase.
The Behaviours of Cementitious Materials in Long Term Storage and Disposal: An Overview of Results of the IAEA Coordinated Research Project

Cementitious materials are widely used in waste management systems with different aims and requirements for long term performance. Both conventional and novel cementitious materials are used to create reliable immobilising elements for safe storage and disposal of wastes. The barrier elements as well as interactions envisaged between various components are important to ultimately ensure the overall safety of a storage/disposal system. The behaviour and performance of cementitious materials including waste package components, wasteform and backfilling were analysed within the IAEA Coordinated Research Project which involved 26 research organizations from 21 Member States MS). The paper presents briefly the main research outcomes for conventional cementitious systems; novel materials and technologies; testing and waste acceptance criteria; and modelling long term behaviour.
People Wait Longer when the Alternative is Risky: The Relation Between Preferences in Risky and Inter‐temporal Choice

In two experiments, we demonstrate that despite indicating indifference when probed about risk or delay in isolation, when forced to explicitly trade-off between the two, participants prefer delayed over risky rewards. This pattern of findings sets a boundary condition for any common utility-based comparison process involving both risk and delay. Furthermore, this change from indifference-in-isolation to delay-preference-in-a-trade-off strengthens as reward amount increases. Exploratory modeling results suggest that the shift in preference can be explained by allowing for different discount rates for delay-only choices compared with when delay is in competition with risk. This explanation is better than one in which probability weighting is different between risk-only choices and risks considered in the presence of a delay. Together, the empirical and modeling work lays a path for future investigations of why and when people's evaluation of the properties of risky and delayed choices vary as a function of the alternatives on offer. Copyright © 2017 John Wiley & Sons, Ltd.
On the Security of the Yeung Mintzer Authentication Watermark

The recent proliferation of digital multimedia content h raised concerns about authentication mechanisms for m timedia data. A number of authentication techniques ba on digital watermarks have been proposed in the literatu In this paper we examine the security of the Yeung-Mintz authentication watermarking technique. We show that un some conditions the Yeung-Mintzer technique is susce ble to impersonation attacks. We then propose some s ple modifications to the technique that make it more rob against substitution and impersonation attacks.
Shedding Light on the Microbial Community of the Macropod Foregut Using 454-Amplicon Pyrosequencing

Twenty macropods from five locations in Queensland, Australia, grazing on a variety of native pastures were surveyed and the bacterial community of the foregut was examined using 454-amplicon pyrosequencing. Specifically, the V3/V4 region of 16S rRNA gene was examined. A total of 5040 OTUs were identified in the data set (post filtering). Thirty-two OTUs were identified as ‘shared’ OTUS (i.e. present in all samples) belonging to either Firmicutes or Bacteroidetes (Clostridiales/Bacteroidales). These phyla predominated the general microbial community in all macropods. Genera represented within the shared OTUs included: unclassified Ruminococcaceae, unclassified Lachnospiraceae, unclassified Clostridiales, Peptococcus sp. Coprococcus spp. , Streptococcus spp. , Blautia sp. , Ruminoccocus sp. , Eubacterium sp. , Dorea sp. , Oscillospira sp. and Butyrivibrio sp. The composition of the bacterial community of the foregut samples of each the host species (Macropus rufus, Macropus giganteus and Macropus robustus) was significantly different allowing differentiation between the host species based on alpha and beta diversity measures. Specifically, eleven dominant OTUs that separated the three host species were identified and classified as: unclassified Ruminococcaceae, unclassified Bacteroidales, Prevotella spp. and a Syntrophococcus sucromutans. Putative reductive acetogens and fibrolytic bacteria were also identified in samples. Future work will investigate the presence and role of fibrolytics and acetogens in these ecosystems. Ideally, the isolation and characterization of these organisms will be used for enhanced feed efficiency in cattle, methane mitigation and potentially for other industries such as the biofuel industry.
Recent Perspectives Regarding the Role of Dietary Protein for the Promotion of Muscle Hypertrophy with Resistance Exercise Training

Skeletal muscle supports locomotion and serves as the largest site of postprandial glucose disposal; thus it is a critical organ for physical and metabolic health. Skeletal muscle mass is regulated by the processes of muscle protein synthesis (MPS) and muscle protein breakdown (MPB), both of which are sensitive to external loading and aminoacidemia. Hyperaminoacidemia results in a robust but transient increase in rates of MPS and a mild suppression of MPB. Resistance exercise potentiates the aminoacidemia-induced rise in MPS that, when repeated over time, results in gradual radial growth of skeletal muscle (i.e., hypertrophy). Factors that affect MPS include both quantity and composition of the amino acid source. Specifically, MPS is stimulated in a dose-responsive manner and the primary amino acid agonist of this process is leucine. MPB also appears to be regulated in part by protein intake, which can exert a suppressive effect on MPB. At high protein doses the suppression of MPB may interfere with skeletal muscle adaptation following resistance exercise. In this review, we examine recent advancements in our understanding of how protein ingestion impacts skeletal muscle growth following resistance exercise in young adults during energy balance and energy restriction. We also provide practical recommendations for exercisers who wish to maximize the hypertrophic response of skeletal muscle during resistance exercise training.
Sequence and Expression Characteristics of Long Noncoding RNAs in Honey Bee Caste Development – Potential Novel Regulators for Transgressive Ovary Size

Division of labor in social insect colonies relies on a strong reproductive bias that favors queens. Although the ecological and evolutionary success attained through caste systems is well sketched out in terms of ultimate causes, the molecular and cellular underpinnings driving the development of caste phenotypes are still far from understood. Recent genomics approaches on honey bee developmental biology revealed a set of genes that are differentially expressed genes in larval ovaries and associated with transgressive ovary size in queens and massive cell death in workers. Amongst these, two contigs called special attention, both being over 200 bp in size and lacking apparent coding potential. Herein, we obtained their full cDNA sequences. These and their secondary structure characteristics placed in evidence that they are bona fide long noncoding RNAs (lncRNA) differentially expressed in larval ovaries, thus named lncov1 and lncov2. Genomically, both map within a previously identified QTL on chromosome 11, associated with transgressive ovary size in honey bee workers. As lncov1 was over-expressed in worker ovaries we focused on this gene. Real-time qPCR analysis on larval worker ovaries evidenced an expression peak coinciding with the onset of autophagic cell death. Cellular localization analysis through fluorescence in situ hybridization revealed perinuclear spots resembling omega speckles known to regulate trafficking of RNA-binding proteins. With only four lncRNAs known so far in honey bees, two expressed in the ovaries, these findings open a novel perspective on regulatory factors acting in the fine tuning of developmental processes underlying phenotypic plasticity related to social life histories.
Nontypeable Haemophilus influenzae Genetic Islands Associated with Chronic Pulmonary Infection

Background Haemophilus influenzae (Hi) colonizes the human respiratory tract and is an important pathogen associated with chronic obstructive pulmonary disease (COPD). Bacterial factors that interact with the human host may be important in the pathogenesis of COPD. These factors, however, have not been well defined. The overall goal of this study was to identify bacterial genetic elements with increased prevalence among H. influenzae strains isolated from patients with COPD compared to those isolated from the pharynges of healthy individuals. Methodology/Principal Findings Four nontypeable H. influenzae (NTHi) strains, two isolated from the airways of patients with COPD and two from a healthy individual, were subjected to whole genome sequencing using 454 FLX Titanium technology. COPD strain-specific genetic islands greater than 500 bp in size were identified by in silico subtraction. Open reading frames residing within these islands include known Hi virulence genes such as lic2b, hgbA, iga, hmw1 and hmw2, as well as genes encoding urease and other enzymes involving metabolic pathways. The distributions of seven selected genetic islands were assessed among a panel of 421 NTHi strains of both disease and commensal origins using a Library-on-a-Slide high throughput dot blot DNA hybridization procedure. Four of the seven islands screened, containing genes that encode a methyltransferase, a dehydrogenase, a urease synthesis enzyme, and a set of unknown short ORFs, respectively, were more prevalent in COPD strains than in colonizing strains with prevalence ratios ranging from 1.21 to 2.85 (p≤0.0002). Surprisingly, none of these sequences show increased prevalence among NTHi isolated from the airways of patients with cystic fibrosis. Conclusions/Significance Our data suggest that specific bacterial genes, many involved in metabolic functions, are associated with the ability of NTHi strains to survive in the lower airways of patients with COPD.
The Costs of Multitasking in Threaded Cognition

Most multitasking models make use of executive processes to assign resources to tasks (Kieras et al., 2000). An alternative is to have no executive, but constrain individual processes so that they share resources in a plausible way. Salvucci and Taatgen (under revision) in their theory of threaded cognition have shown how peripheral resources and declarative memory are shared between processes without an executive. In this paper we will extend this work by showing how two tasks share a resource to store the problem representation in a dualtask paradigm where either task sometimes needs a problem representation and sometimes not. Threaded cognition predicts extra interference when both tasks need a problem representation, which is what we found in the experiment.