Miracle-dz/UniFAR-FTUs huggingface dataset:
A faster algorithm for minimum cost submodular flows

This paper presents a cycle canceling algorithm for the submodular flow problem. The algorithm uses an assignment problem whose optimal solution identifies most negative vertex-disjoint cycles in the auxiliary network. The cost scaling version of this algorithm runs in O(n4h 1ognC) time, where n is the number of vertices, h is the time for computing an exchange capacity, and C is the maximum absolute value of arc costs. This improves the best previously known weakly polynomial bound due to Cunningham and Frank.
Intuitive Participation in Aggressive Intergroup Conflict: Evidence of Weak Versus Strong Parochial Altruism

Humans are unusually cooperative and prosocial, sharing resources with kin and non-kin others. At the same time, they engage in violent intergroup conflict and discriminate against members of other groups. How can we explain this apparent inconsistency? Building on Darwin (1871), it has been proposed that self-sacrificing prosociality toward the in-group and hostility toward the out-group may have co-evolved (Choi and Bowles, 2007; Garcia and van den Bergh, 2011). Research on so-called parochial altruism, i.e., the motivation to benefit in-group members at personal cost, while not benefitting or even harming out-group members, recently received much attention in psychology and beyond (for reviews see, De Dreu et al., 2014; Rusch, 2014; Yamagishi and Mifune, 2016). Empirical studies aiming to support the parochial altruism hypothesis yielded mixed results, though. For instance, whereas some studies provided support for the parochial altruism hypothesis (e.g., Bernhard et al., 2006; Abbink et al., 2012), others failed to show a relationship between individual-level prosociality and intergroup discrimination (e.g., Corr et al., 2015). And yet others found that prosocial individuals are less likely to discriminate against out-group members (e.g., Thielmann and Bohm, in press).
Development of a Reactive Stroma Associated with Prostatic Intraepithelial Neoplasia in EAF2 Deficient Mice

ELL-associated factor 2 (EAF2) is an androgen-responsive tumor suppressor frequently deleted in advanced prostate cancer that functions as a transcription elongation factor of RNA Pol II through interaction with the ELL family proteins. EAF2 knockout mice on a 129P2/OLA-C57BL/6J background developed late-onset lung adenocarcinoma, hepatocellular carcinoma, B-cell lymphoma and high-grade prostatic intraepithelial neoplasia. In order to further characterize the role of EAF2 in the development of prostatic defects, the effects of EAF2 loss were compared in different murine strains. In the current study, aged EAF2−/− mice on both the C57BL/6J and FVB/NJ backgrounds exhibited mPIN lesions as previously reported on a 129P2/OLA-C57BL/6J background. In contrast to the 129P2/OLA-C57BL/6J mixed genetic background, the mPIN lesions in C57BL/6J and FVB/NJ EAF2−/− mice were associated with stromal defects characteristic of a reactive stroma and a statistically significant increase in prostate microvessel density. Stromal inflammation and increased microvessel density was evident in EAF2-deficient mice on a pure C57BL/6J background at an early age and preceded the development of the histologic epithelial hyperplasia and neoplasia found in the prostates of older EAF2−/− animals. Mice deficient in EAF2 had an increased recovery rate and a decreased overall response to the effects of androgen deprivation. EAF2 expression in human cancer was significantly down-regulated and microvessel density was significantly increased compared to matched normal prostate tissue; furthermore EAF2 expression was negatively correlated with microvessel density. These results suggest that the EAF2 knockout mouse on the C57BL/6J and FVB/NJ genetic backgrounds provides a model of PIN lesions associated with an altered prostate microvasculature and reactive stromal compartment corresponding to that reported in human prostate tumors.
Cost-Effectiveness of Early Infant HIV Diagnosis of HIV-Exposed Infants and Immediate Antiretroviral Therapy in HIV-Infected Children under 24 Months in Thailand

Background HIV-infected infants have high risk of death in the first two years of life if untreated. WHO guidelines recommend early infant HIV diagnosis (EID) of all HIV-exposed infants and immediate antiretroviral therapy (ART) in HIV-infected children under 24-months. We assessed the cost-effectiveness of this strategy in HIV-exposed non-breastfed children in Thailand. Methods A decision analytic model of HIV diagnosis and disease progression compared: EID using DNA PCR with immediate ART (Early-Early); or EID with deferred ART based on immune/clinical criteria (Early-Late); vs. clinical/serology based diagnosis and deferred ART (Reference). The model was populated with survival and cost data from a Thai observational cohort and the literature. Incremental cost-effectiveness ratio per life-year gained (LYG) was compared against the Reference strategy. Costs and outcomes were discounted at 3%. Results Mean discounted life expectancy of HIV-infected children increased from 13.3 years in the Reference strategy to 14.3 in the Early-Late and 17.8 years in Early-Early strategies. The mean discounted lifetime cost was $17,335, $22,583 and $29,108, respectively. The cost-effectiveness ratio of Early-Late and Early-Early strategies was $5,149 and $2,615 per LYG, respectively as compared to the Reference strategy. The Early-Early strategy was most cost-effective at approximately half the domestic product per capita per LYG ($4,420 in Thailand 2011). The results were robust in deterministic and probabilistic sensitivity analyses including varying perinatal transmission rates. Conclusion In Thailand, EID and immediate ART would lead to major survival benefits and is cost- effective. These findings strongly support the adoption of WHO recommendations as routine care.
PID-state control with restricted structure for electromechanical drive train

Numerous technical processes with stochastic workflow, such as the shredder process, show high load peaks. Those load peaks propagate in the power train of the electromechanical drive system to the feeding power grid and at the same time excite torsional oscillations. For smoothing the load peaks as well as damping the torque oscillations a novel torque control was designed. The concept consists of a PID-state control and was compared to standard control methods such as standard PID control.
Using MUXs network to hide bunches of scan chains

This paper presents a decompression architecture using a periodically alterable MUX network. Compared to the static XOR network, the periodically alterable MUX network has multiple configurations to decode the input information flexibly. Probability analysis can help us to select the proper parameter when considering the DFT schemes. With the dedicated efforts, smaller test data volume and test application time can be achieved compared to previous techniques.
Orofacial Granulomatosis - A Rare Case Report with Review of Literature

The term orofacial granulomatosis (OFG) is a descriptive term used for granulomatous disorders affecting the face and oral cavity, which can occur for a variety of reasons resulting in significant morbidity. It is characterised by persistent swelling that may involve one or both the lips and /or recurrent ulcers and a variety of other orofacial features. Medical history is very important in the diagnosis of OFG as medical condition like Crohn’s disease can also present an extra intestinal manifestation of OFG. Exclusion of other entities like sarcoidosis, mycobacterial infections, foreign body reactions and biopsy helps to establish a correct diagnosis. Herein we report a case of OFG in a 55 year old female patient with review of literature.
The effect of temperature and lipid on the conformational transition of gramicidin A in lipid vesicles

The present study investigated the effect of temperature and lipid/peptide molar ratio on the conformational changes of the membrane peptide gramicidin A from a double‐stranded helix to a single‐stranded helical dimmer in 1,2‐dimyristoyl‐glycerol‐3‐phosphochloine (DMPC) vesicles. Tryptophan fluorescence spectroscopy results suggested that the conformational transition fitted a three‐state (two‐step) “folding” model. Rate constants, k1 and k2, were determined for each of the two steps. Since k1 and k2 increased with an increase in temperature, we hypothesized that the process corresponded to the breakage and formation of the backbone hydrogen bonds. The k1 was from 10 to 45 folds faster than k2, except for lipid/peptide molar ratios above 89.21, where k2 increased rapidly. At molar ratios below 89.21, k2 was insensitive to changes in lipid concentration. To account for this phenomenon, we proposed that while the driving interaction at high molar ratios is between the indole rings of the tryptophan residues and the lipid head groups, at low molar ratios there may be an intermolecular interaction between the tryptophan residues that causes gramicidin A to form an organized aggregated network. This aggregated network, caused by the tryptophan–tryptophan interaction, may be the main effect responsible for the slow down of the conformation change. © 2005 Wiley Periodicals, Inc. Biopolymers 78: 179–186, 2005
Registration of the vertebrae

The vertebrae registration is very important to treat the vertebrae diseases. As the vertebrae has rigid bones and soft tissue, the traditional nonrigid registration canpsilat work well on that. In this paper, a novel multi-stage nonrigid registration with rigid constraint to the vertebrae is presented. Firstly, A new rigid transform constraint is introduced, which penalizes nonrigid deformations at locations where it is required. The nonrigid registration method based on B-Spline is extended to allow the incorporation of the rigid transformation. Secondly, the vertebrae registration using the vertebrae property and the nonrigid registration with rigid constraint is introduced. Thirdly the registration experiments are performed on 2D synthetic data and the vertebrae slices. Experiments show that the proposed registration with rigid constraint is successful to improve the vertebrae registration quality.
Estimating domain-based user influence in social networks

Social networks and microblogging systems play a fundamental role in the diffusion of information. The information, from different sources, reaches each user through multiple connections, the study of which is indispensable for the sake of understanding the dynamics of its evolution and expansion. In this paper, we propose a system which enables to delve in the spread of information over a network along with the changes in the user relationships with respect to the domain of discussion. To cope up with the goal, considering Twitter as a case study, we analyse the tweets as the starting point or as the generators of the information which later flows through subsequent retweets. Furthermore, we integrate a N-Gram model classification approach for categorizing, under various domains, the information shared within the social network under consideration. We finally leverage this formalization to propose a domain-based model which aims to estimate the influence of a user, on a community, in the domain under consideration. In conclusion, using a sample of the Twitter network we then present a set of case studies and real case scenarios that show the validity of the proposed approach.
Flexible Decomposition Algorithms for Weakly Coupled Markov Decision Problems

This paper presents two new approaches to decomposing and solving large Markov decision problems (MDPs), a partial decoupling method and a complete decoupling method. In these approaches, a large, stochastic decision problem is divided into smaller pieces. The first approach builds a cache of policies for each part of the problem independently, and then combines the pieces in a separate, light-weight step. A second approach also divides the problem into smaller pieces, but information is communicated between the different problem pieces, allowing intelligent decisions to be made about which piece requires the most attention. Both approaches can be used to find optimal policies or approximately optimal policies with provable bounds. These algorithms also provide a framework for the efficient transfer of knowledge across problems that share similar structure.
Queries by Example or by Filters : Design and Empirical Evaluation

Specifying event sequence queries is challenging even for skilled computer professionals familiar with SQL. Most graphical user interfaces for database search use a query-by-filters approach, which is often effective, but applies an exact match criteria. We describe a new query-by-example interface, in which users specify a pattern by simply placing events on a blank timeline, producing a similarityranked list of results. Users customize the similarity measure by four decision criteria, enabling them to adjust the impact of missing, extra, or swapped events or the impact of time shifts. We describe an example of use with electronic health records based on our ongoing collaboration with hospital physicians. Then we report on a controlled experiment with 18 participants that compared query-by-filters and query-by-example features. We report on the advantages and disadvantages of each approach and conclude with recommendations for the design of a hybrid approach combining both interfaces.
Efficacy of a non-updated, Matrix-C-based equine influenza subunit-tetanus vaccine following Florida sublineage clade 2 challenge

Assessing the ability of current equine influenza vaccines to provide cross-protection against emerging strains is important. Horses not vaccinated previously and seronegative for equine influenza based on haemagglutination inhibition (HI) assay were assigned at random to vaccinated (n=7) or non-vaccinated (control, n=5) groups. Vaccination was performed twice four weeks apart with a 1 ml influenza subunit (A/eq/Prague/1/56, A/eq/Newmarket/1/93, A/eq/Newmarket/2/93), tetanus toxoid vaccine with Matrix-C adjuvant (EquilisPrequenza Te). All the horses were challenged individually by aerosol with A/eq/Richmond/1/07 three weeks after the second vaccination. Rectal temperature, clinical signs, serology and virus excretion were monitored for 14 days after challenge. There was no pain at the injection site or increases in rectal temperature following vaccination. Increases in rectal temperature and characteristic clinical signs were recorded in the control horses. Clinical signs were minimal in vaccinated horses. Clinical (P=0.0345) and total clinical scores (P=0.0180) were significantly lower in the vaccinated than in the control horses. Vaccination had a significant effect on indicators of viraemia – the extent (P=0.0006) and duration (P=<0.0001) of virus excretion and the total amount of virus excreted (AUC, P=0.0006). Vaccination also had a significant effect (P=0.0017) on whether a horse was positive or negative for virus excretion during the study. Further research is needed to fully understand the specific properties of this vaccine that may contribute to its cross-protective capacity.
Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex

Calcium-activated chloride channels of the anoctamin (alias TMEM16) protein family fulfill critical functions in epithelial fluid transport, smooth muscle contraction and sensory signal processing. Little is known, however, about their contribution to information processing in the central nervous system. Here we examined the recent finding that a calcium-dependent chloride conductance impacts on GABAergic synaptic inhibition in Purkinje cells of the cerebellum. We asked whether anoctamin channels may underlie this chloride conductance. We identified two anoctamin channel proteins, ANO1 and ANO2, in the cerebellar cortex. ANO1 was expressed in inhibitory interneurons of the molecular layer and the granule cell layer. Both channels were expressed in Purkinje cells but, while ANO1 appeared to be retained in the cell body, ANO2 was targeted to the dendritic tree. Functional studies confirmed that ANO2 was involved in a calcium-dependent mode of ionic plasticity that reduces the efficacy of GABAergic synapses. ANO2 channels attenuated GABAergic transmission by increasing the postsynaptic chloride concentration, hence reducing the driving force for chloride influx. Our data suggest that ANO2 channels are involved in a Ca2+-dependent regulation of synaptic weight in GABAergic inhibition. Thus, in balance with the chloride extrusion mechanism via the co-transporter KCC2, ANO2 appears to regulate ionic plasticity in the cerebellum.
Effect of extracellular fluid volume on single-sample measurement of glomerular filtration rate.

UNLABELLED Objective. The objective of our study was to evaluate the effect of extracellular fluid volume (ECV) on the accuracy of measurement of glomerular filtration rate from a single sample (GFR1). METHODS Multi-sample GFR (GFR6) and ECV (per 1.73 m(2)) were measured with both Cr-51-EDTA and iohexol, injected into opposite arms (110 studies in 80 subjects). Six plasma samples were obtained bilaterally 20- 240 min post-injection to measure GFR6/1.73 m(2). GFR1/1.73 m(2) was calculated from 2-, 3- and 4-h samples using Jacobsson's formula for iohexol and the Christensen and Groth formula for Cr-51-EDTA. The quotient, GFR1/GFR6, was taken to indicate the accuracy of GFR1. RESULTS When GFR6 was <60 ml/min/1.73 m(2), GFR1/ GFR6 correlated positively with ECV at all single-sample times. When GFR6 was 60-90 ml/min/1.73 m(2) or >90 ml/min/1.73 m(2), GFR1/GFR6 correlated positively with ECV at 2 h, but negatively at 4 h, indicating that at some time between 2 and 4 h, GFR1/GFR6 was transiently independent of ECV. A plot of the regression gradient of GFR1/GFR6 on ECV against sample time indicated that the time of transient independence, at which time GFR1 depends exclusively on GFR6, was 3.2-3.9 h (depending on indicator combination used) when GFR6 was 60-90 ml/min/1.73 m(2) and 2.4-2.9 h when GFR was >90 ml/min/1.73 m(2). Transient independence when GFR6 was <60 ml/min/1.73 m(2) was not reached by 4 h and estimated to be 5-7 h. CONCLUSION The accuracy of GFR1 depends on ECV, overestimation or underestimation respectively depending on sample time and GFR. The time at which GFR1 is independent of ECV increases with decreasing GFR. If sampling time is too early, GFR1 overestimates GFR, but the reverse occurs when sampling is too late, even if GFR is abnormally low.
Directional Modulation Via Symbol-Level Precoding: A Way to Enhance Security

Wireless communication provides a wide coverage at the cost of exposing information to unintended users. As an information-theoretic paradigm, secrecy rate derives bounds for secure transmission when the channel to the eavesdropper is known. However, such bounds are shown to be restrictive in practice and may require exploitation of specialized coding schemes. In this paper, we employ the concept of directional modulation and follow a signal processing approach to enhance the security of multiuser multi-input multioutput (MIMO) communication systems when a multiantenna eavesdropper is present. Security enhancement is accomplished by increasing the symbol error rate at the eavesdropper. Unlike the information-theoretic secrecy rate paradigm, we assume that the legitimate transmitter is not aware of its channel to the eavesdropper, which is a more realistic assumption. We examine the applicability of MIMO receiving algorithms at the eavesdropper. Using the channel knowledge and the intended symbols for the users, we design security enhancing symbol-level precoders for different transmitter and eavesdropper antenna configurations. We transform each design problem to a linearly constrained quadratic program and propose two solutions, namely the iterative algorithm and one based on nonnegative least squares, at each scenario for a computationally efficient modulation. Simulation results verify the analysis and show that the designed precoders outperform the benchmark scheme in terms of both power efficiency and security enhancement.
Expression of multiple cancer-testis antigen genes in gastrointestinal and breast carcinomas

Cancer-testis antigens (CTAs) such as MAGE are selectively expressed in various types of human neoplasms but not in normal tissues other than testis. This characteristic feature of CTAs makes them promising antigens for cancer-specific immunotherapy. A critical requirement for this therapy is identification of promising antigens. In this study, we investigated the expression of 6 genes recently identified by serological analysis of antigens by recombinant expression (SEREX) libraries: NY-ESO-1, LAGE-1, SCP-1, SSX-1, SSX-2, and SSX-4, in many surgical samples of gastrointestinal and breast carcinomas using reverse transcription-polymerase chain reaction. We found relatively high expression of SCP-1 (23.5%) and SSX-4 (20.6%) in gastric carcinoma, LAGE-1 (39.1%) and NY-ESO-1 (23.9%) in oesophageal carcinoma, and SCP-1 (34.1%) in breast carcinoma. We also found frequent synchronous expression with MAGE, including LAGE-1 (46.2%) in oesophageal carcinoma, SSX-4 (46.7%) in gastric carcinoma, and SCP-1 (38.3%) in breast carcinoma. Immunohistochemical analysis of the tumour samples expressing both MAGE-4 and NY-ESO-1 genes demonstrated differences in distribution between MAGE-4 and NY-ESO-1 in serial sections. We concluded that NY-ESO-1, LAGE-1, SCP-1 and SSX-4 genes may be promising candidates for cancer-specific immunotherapy in addition to MAGE, and that polyvalent cancer vaccines may be useful in cases of heterogeneous expressions of CTA genes in gastrointestinal and breast carcinomas. © 2001 Cancer Research Campaign www.bjcancer. com
Enhanced overlapping community detection in social networks using wise initialization

Social networks represent relationships between people. Communities are groups of people with some common interests or features. In this context, overlapping means a community member could be member of some other communities at the same time. In this paper, we introduce a new framework to enhance the performance of overlapping community detection techniques. In this method, the target network is divided into several subnets and after detecting their communities, this information is used as an initialization for the final community detection technique.
Unmixing Aggregate Data: Estimating the Social Composition of Enumeration Districts

In this paper the authors address the problem of interpreting and classifying aggregate data sources and draw parallels between tasks commonly encountered in image processing and census analysis. Both of these fields already have a range of standard classification tools which are applied in such situations, but these are hindered by the aggregate nature of the input data. An approach to ‘unmixing’ aggregate data, and thus to revealing the nature of the subunit variation masked by aggregation, is introduced. This approach has already shown considerable success in Earth Observation applications, and in this paper the authors present the adaptation and application of the approach to Census small area statistics data for Southampton, Hants, revealing something of the social composition of Southampton's enumeration districts. The unmixing technique utilises an artificial neural network.