Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental Determination of the ZIP Coefficients for Modern Residential, Commercial, and Industrial Loads

This paper presents the experimental determination of the ZIP coefficients model to represent (static) modern loads under varying voltage conditions. ZIP are the coefficients of a load model comprised of constant impedance Z, constant current I, and constant power P loads. A ZIP coefficient load model is used to represent power consumed by a load as a function of voltage. A series of surveys was performed on typical residential, commercial, and industrial customers in New York City. Household appliances and industrial equipment found in the different locations were tested in the laboratory by varying the voltage from 1.1-p.u. voltage to 0 and back to 1.1 pu in steps of 3 V to obtain the individual P- V, Q- V, and I- V characteristics. Customer load tables were built using seasonal factors and duty cycles to form weighted contributions for each device in every customer class. The loads found in several residential classes were assembled and tested in the lab. It was found that modern appliances behave quite differently than older appliances even from only 10 years back. Models of the different customer classes were validated against actual recordings of load variations under voltage reduction.
Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury

The signaling molecule adenosine has been implicated in attenuating acute lung injury (ALI). Adenosine signaling is terminated by its uptake through equilibrative nucleoside transporters (ENTs). We hypothesized that ENT‐dependent adenosine uptake could be targeted to enhance adenosine‐mediated lung protection. To address this hypothesis, we exposed mice to high‐pressure mechanical ventilation to induce ALI. Initial studies demonstrated time‐dependent repression of ENT1 and ENT2 transcript and protein levels during ALI. To examine the contention that ENT repression represents an endogenous adaptive response, we performed functional studies with the ENT inhibitor dipyridamole. Dipyridamole treatment (1 mg/kg; EC50=10 μM) was associated with significant increases in ALI survival time (277 vs. 395 min; P<0.05). Subsequent studies in gene‐targeted mice for Ent1 or Ent2 revealed a selective phenotype in Ent2‐/‐ mice, including attenuated pulmonary edema and improved gas exchange during ALI in conjunction with elevated adenosine levels in the bronchoalveolar fluid. Furthermore, studies in genetic models for adenosine receptors implicated the A2B adenosine receptor (Adora2b) in mediating ENT‐dependent lung protection. Notably, dipyridamole‐dependent attenuation of lung inflammation was abolished in mice with alveolar epithelial Adora2b gene deletion. Our newly identified crosstalk pathway between ENT2 and alveolar epithelial Adora2b in lung protection during ALI opens possibilities for combined therapies targeted to this protein set. —Eckle, T. , Hughes, K. , Ehrentraut, H. , Brodsky, K. S. , Rosenberger, P., Choi, D. ‐S. , Ravid, K. , Weng, T. , Xia, Y. , Blackburn, M. R.Eltzschig, H. K. , Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury. FASEB J. 27, 3078–3089 (2013). www.fasebj. org
La méthode de fouille de Maurice Dunand à Byblos. I. M. Dunand et l'archéologie au Proche-Orient au début du XXe siècle

Leriche Pierre. La methode de fouille de Maurice Dunand a Byblos. I. M. Dunand et l'archeologie au Proche-Orient au debut du XXe siecle. In: Topoi, volume 5/2, 1995. pp. 439-452.
Reliable Shortest Path Problems in Stochastic Time-Dependent Networks

This study investigates the time-dependent reliable shortest path problem (TD-RSPP), which is commonly encountered in congested urban road networks. Two variants of TD-RSPP are considered in this study. The first variant is to determine the earliest arrival time and associated reliable shortest path for a given departure time, referred to as the “forward” TD-RSPP. The second problem is to determine the latest departure time and associated reliable shortest path for a given preferred arrival time, referred as the “backward” TD-RSPP. It is shown in this article that TD-RSPP is not reversible. The backward TD-RSPP cannot be solved by the algorithms designed for the forward problem using the reverse search from destination to origin. In this study, two efficient solution algorithms are proposed to solve the forward and backward TD-RSPP exactly and the optimality of proposed algorithms is rigorously proved. The proposed solution algorithms have potential applications in both advanced traveler information systems and stochastic dynamic traffic assignment models.
Marcelo Garnier Mota EXPLORING STRUCTURED INFORMATION RETRIEVAL FOR BUG LOCALIZATION IN C # SOFTWARE PROJECTS

Mota, Marcelo Garnier; Garcia, Alessandro Fabrício (Advisor). Exploring structured information retrieval for bug localizati on in C# software projects. Rio de Janeiro, 2016. 91p. MSc. Dissertation – De partamento de Informática, Pontifícia Universidade Católica do Ri o de Janeiro. Software projects can grow very rapidly, reaching h undreds or thousands of files in a relatively short time span. Therefore, m anually finding the source code parts that should be changed in order to fix a bug is a difficult task. Static bug localization techniques provide effective means of finding files related to a bug. Recently, structured information retrieval has been used to improve the effectiveness of static bug localization, being suc cessfully applied by techniques such as BLUiR, BLUiR+, and AmaLgam. However, there are significant shortcomings on how these techniques were evaluated . BLUiR, BLUiR+, and AmaLgam were tested only with four projects, all of them structured with the same language, namely, Java. Moreover, the evaluations o f these techniques (i) did not consider appropriate program versions, (ii) include d bug reports that already mentioned the bug location, and (iii) did not exclu de spurious files, such as test files. These shortcomings suggest the actual effect iveness of these techniques may be lower than reported in recent studies. Furthermo re, there is limited knowledge on whether and how the effectiveness of these state -of-the-art techniques can be improved. In this dissertation, we evaluate the thr e aforementioned techniques on 20 open-source C# software projects, providing a ri gorous assessment of the effectiveness of these techniques on a previously u ntested object-oriented language. Moreover, we address the simplistic assumptions com m nly present in bug localization studies, thereby providing evidence on how their findings may be biased. Finally, we study the contribution of diffe rent program construct types to bug localization. This is a key aspect of how struc tured information retrieval is applied in bug localization. Therefore, understandi ng how each construct type influences bug localization may lead to effectivene ss improvements in projects structured with a specific programming language, su ch as C#.
A CORRELATION TENSOR – BASED MODEL FOR TIME VARIANT FREQUENC Y SELECTIVE MIMO CHANNELS

In this contribution we present a new analytical channel model for frequency selective, time variant MIMO systems. The model is based on a correlation tensor, which allows a natural description of multi–dimensional signals. By appl ying the Higher Order Singular Value Decomposition (HOSVD), we gain a better insight into the multi–dimensional eigenstructure of the channel. Applications of the model include the denoising of measured channels and the possibility to generate new synthetic channels displaying a give n correlation in time, frequency, and space. The proposed model possesses advantages over existing 2–dimensional ei genmode–based channel models. In contrast to them, the tensor–based model can cope with frequency and time selectivity in a natural way.
Targeting of the chemotaxis methylesterase/deamidase CheB to the polar receptor–kinase cluster in an Escherichia coli cell

Chemotactic adaptation to persisting stimulation involves reversible methylation of the chemoreceptors that form complexes with the histidine kinase CheA at a cell pole. The methyltransferase CheR targets to the C‐terminal NWETF sequence of the chemoreceptor. In contrast, localization of the methylesterase CheB is largely unknown, although regulation of its activity via phosphorylation is central to adaptation. In this study, green fluorescent protein was fused to full‐length CheB or its various parts: the N‐terminal regulatory domain (N), the C‐terminal catalytic domain (C) and the linker (L). The full‐length and NL fusions and, to a lesser extent, the LC fusion localized to a pole. Deletion of the P2 domain from CheA abolished polar localization of the full‐length and NL fusions, but did not affect that of the LC fusion. Pull‐down assays demonstrated that the NL fragment, but not the LC fragment, binds to the P2 fragment of CheA. These results indicate that binding of the NL domain to the P2 domain targets CheB to the polar signalling complex. The LC fusion, like the chemoreceptor, partially localized in the absence of CheA, suggesting that the LC domain may interact with its substrate sites, either as part of the protein or as a proteolytic fragment.
Replication of Murine Hepatitis Virus Is Regulated by Papain-Like Proteinase 1 Processing of Nonstructural Proteins 1, 2, and 3

ABSTRACT Coronaviruses are positive-strand RNA viruses that translate their genome RNA into polyproteins that are co- and posttranslationally processed into intermediate and mature replicase nonstructural proteins (nsps). In murine hepatitis virus (MHV), nsps 1, 2, and 3 are processed by two papain-like proteinase activities within nsp3 (PLP1 and PLP2) to yield nsp1, an nsp2-3 intermediate, and mature nsp2 and nsp3. To determine the role in replication of processing between nsp2 and nsp3 at cleavage site 2 (CS2) and PLP1 proteinase activity, mutations were engineered into the MHV genome at CS2, at CS1 and CS2, and at the PLP1 catalytic site, alone and in combination. Mutant viruses with abolished cleavage at CS2 were delayed in growth and RNA synthesis but grew to wild-type titers of >107 PFU/ml. Mutant viruses with deletion of both CS1 and CS2 exhibited both a delay in growth and a decrease in peak viral titer to ∼104 PFU/ml. Inactivation of PLP1 catalytic residues resulted in a mutant virus that did not process at either CS1 or CS2 and was severely debilitated in growth, achieving only 102 PFU/ml. However, when both CS1 and CS2 were deleted in the presence of inactivated PLP1, the growth of the resulting mutant virus was partially compensated, comparable to that of the CS1 and CS2 deletion mutant. These results demonstrate that interactions of PLP1 with CS1 and CS2 are critical for protein processing and suggest that the interactions play specific roles in regulation of the functions of nsp1, 2, and 3 in viral RNA synthesis.
Detection and Prevalence of Active Drug Efflux Mechanism in Various Multidrug-Resistant Klebsiella pneumoniae Strains from Turkey

ABSTRACT The prevalence of active drug efflux pump and porin alterations was investigated in Turkish nosocomial strains of Klebsiella pneumoniae exhibiting a multidrug-resistant phenotype. MICs of various antibiotics, including quinolones, chloramphenicol, tetracycline, and β-lactams, for those strains were determined either with or without the efflux pump inhibitor phenylalanine arginine β-naphthylamide (PAβN). Thirty-nine percent of the strains exhibited a PAβN-modulated resistance for quinolones, chloramphenicol, and tetracycline. In these strains, a significant increase of chloramphenicol accumulation was gained in the presence of the efflux pump inhibitor PAβN or with the energy uncoupler carbonyl cyanide m-chlorophenylhydrazone. Moreover, high-level expression of the membrane fusion protein AcrA, which was immunodetected in most of those isolates, suggests that the AcrAB/TolC efflux machinery contributed to their antibiotic resistance. Studies of K. pneumoniae porins indicated that the majority of the strains, including extended-spectrum β-lactamase producers and efflux-positive ones, presented an alteration in their sorbitol-sensitive porin (OmpK35) expression. This is the first report showing the prominent role of active drug efflux in the antibiotic resistance of nosocomial K. pneumoniae strains from Turkey.
On the action of strophanthin G.

The inhibitory effect of ouabain on Na- and K-activated ATP-ase of rat brain lipoprotein is reduced when the incubation temperature is lowered. The concentration of K+ required for maximal ATP-ase activity is also reduced at lower temperatures of incubation. The apparent increase in affinity for K+ by the enzyme system at lower incubation temperatures could be responsible for the change in the effectiveness of ouabain. Increase in enzyme protein concentration also reduces the inhibition produced by a given concentration of ouabain, which appears to be due to binding of ouabain by the lipoprotein. From the titration of enzyme by ouabain it is possible to estimate that 5 × 1014 molecules of ouabain are taken up per milligram of lipoprotein.
Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter.

Monoamine oxidases catalyse the oxidative degradation of biogenic amines including neurotransmitters such as noradrenaline, dopamine, and 5-hydroxytryptamine (5-HT). Three groups have reported positive associations of the monoamine oxidase A (MAOA) gene with bipolar affective disorder although other studies have been negative. In an extension of a previous study [Rubinsztein et al., 1996: Human Molec Genet 5:779-782] we report association studies of MAOA polymorphic markers and affective disorders. The polymorphisms comprised a CA-repeat microsatellite in intron 2 and a Fnu4HI G/T silent polymorphism at position 941 of the cDNA sequence. No significant differences were found when the control allele frequencies were compared with those in bipolar, unipolar, or combined bipolar + unipolar groups. Meta-analyses were then performed to include the data of all published studies using the MAOA microsatellite and Fnu4HI polymorphisms. Separate meta-analyses were performed for Caucasian and Japanese studies, as allele frequencies of the microsatellite in these populations were markedly different. Associations of bipolar affective disorder in pooled male and female groups were found with the MAOA microsatellite in both the Caucasian (P < 0.02) and the Japanese (P < 0.02) meta-analyses. In view of these positive associations, and as previous results have shown that coding variants do not account for the normal population variation in MAOA activity, over 1,300 bp of the promoter were sequenced in 22 bipolar cases and 1 control. A novel polymorphic promoter variable number of tandem repeats (VNTR) located approximately 1,200 bp upstream from the translation start site was demonstrated. However, there was no association of this promoter VNTR with affective disorder. These results suggest that there may be functional variants in other regions of the MAOA gene or neighbouring genes that affect bipolar affective disorder risk.
Identification of novel chromatin-associated proteins involved in programmed genome rearrangements in Tetrahymena

Extensive DNA rearrangements occur during the differentiation of the developing somatic macronuclear genome from the germ line micronuclear genome of Tetrahymena thermophila. To identify genes encoding proteins likely to be involved in this process, we devised a cytological screen to find proteins that specifically localize in macronuclear anlagen (Lia proteins) at the stage when rearrangements occur. We compared the localization of these with that of the chromodomain protein, Pdd1p, which is the most abundant known participant in this genome reorganization. We show that in live cells, Pdd1p exhibits dynamic localization, apparently shuttling from the parental to the developing nuclei through cytoplasmic bodies called conjusomes. Visualization of GFP-tagged Pdd1p also highlights the substantial three-dimensional nuclear reorganization in the formation of nuclear foci that occur coincident with DNA rearrangements. We found that late in macronuclear differentiation, four of the newly identified proteins are organized into nuclear foci that also contain Pdd1p. These Lia proteins are encoded by primarily novel genes expressed at the beginning of macronuclear differentiation and have properties or recognizable domains that implicate them in chromatin or nucleic acid binding. Three of the Lia proteins also localize to conjusomes, a result that further implicates this structure in the regulation of DNA rearrangement.
[Efficacy observation on the needling depth recorded in Lingshu (Miraculous Pivot) for irritable bowel syndrome of diarrhea].

OBJECTIVE To observe the clinical efficacy of the needling depth recorded in Lingshu (Miraculous Pivot) for irritable bowel syndrome of diarrhea (IBS-D) in Germany. METHODS With the needling technique recorded in Lingshu: Jingshui (Miraculous Pivot: Meridian Water), 21 cases of IBSD were treated with acupuncture at Zhangmen(lR 13), Zhongwan(CV 12), Tianshu (ST 25), Guanyuan(CV 4), Qimen (LR 14), Quchi (LI 11), Hegu (LI 4), Yinlingquan(SP 9), Zusanli (ST 36) and Taichong (LR 3), 0. 1-0. 6 cun (2-12 mm) in depth. Even needling technique was applied. The treatment was given 2-3 times each week, and 8 treatments made one session. The efficacy and the scale for the severity degree of symptom (IBS-SSS) were observed in 1-2 sessions of treatment. RESULTS The total effective rate was 52.4% (11/21) in the 1st session and was 90.5% (19/21) in the 2nd session. The efficacy in the 2nd session was superior to that in the 1st session (P < 0.05). IBS-SSS was 143.58 +/- 70.15 in the 1st session and was 115.98 +/- 72.68 in the 2nd session, all reduced obviously as compared with those before treatment (all P < 0.01). The reducing degree in the 2nd session was much remarkable than that in the 1st session (P < 0.05). CONCLUSION The better clinical efficacy has been achieved for IBS-D treated with needling depth recorded in Lingshu (Miraculous Pivot) in Germany. The longer session of treatment is, the better efficacy is obtained.
Cytomegalovirus "missing" capsid protein identified as heat-aggregable product of human cytomegalovirus UL46

Capsids of human and simian strains of cytomegalovirus (HCMV and SCMV, respectively) have identified counterparts for all but one of the protein components of herpes simplex virus (HSV) capsids. The open reading frames (ORFs) for the CMV and HSV counterpart proteins are positionally homologous in the two genomes. The HSV capsid protein without a recognized counterpart in CMV is VP19c, a 50-kDa element of the intercapsomeric "triplex. " VP19c is encoded by HSV ORF UL38, whose positional homolog in the HCMV genome is UL46. The predicted protein product of HCMV UL4A6, however, has essentially no amino acid sequence similarity to HSV VP19c, is only two-thirds as long, and was not recognized as a component of CMV capsids. To identify and learn more about the protein encoded by HCMV UL46, we have expressed it in insect cells from a recombinant baculovirus and tested for its presence in CMV-infected human cells and virus particles with two UL4A6-specific antipeptide antisera. Results presented here show that this HCMV protein (i) has a size of approximately 30 kDa as expressed in both recombinant baculovirus-infected insect cells and HCMV-infected human cells; (ii) has a homolog in SCMV; (iii) is a capsid component and is present in a 1:2 molar ratio with the minor capsid protein (mCP), encoded by UL85; and (iv) interacts with the mCP, which is also shown to interact with itself as demonstrated by the GAL4 two-hybrid system; and (v) aggregates when heated and does not enter the resolving gel during sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), a characteristic that accounts for it eluding detection until now. We call this protein the mCP-binding protein, and on the basis of the characteristics that it shares with HSV VP19c, we conclude that the HCMV mCP-binding protein is the functional as well as genetic homolog of HSV VP19c.
The God of Joshua…Give or Take the Land

YHWH, the God of Israel, is not only a character embedded in the plot of the Book of Joshua. YHWH is the chief protagonist and the engine that drives the plot. Even when there are other actors in the plot, notably Joshua, their performances in the plot are at the behest of and in response to the intention of YHWH.
Automatic Rush Generation with Application to Theatre Performances. (Généation Automatique de Prises de Vues Cinématographiques avec Applications aux Captations de Théâtre)

Professional quality videos of live staged performances are created by recording them from different appropriate viewpoints. These are then edited together to portray an eloquent story replete with the ability to draw out the intended emotion from the viewers. Creating such competent videos, involves the combination of multiple high quality cameras and skilled camera operators. We present a thesis to make even the low budget productions adept and pleasant by producing professional quality vidoes sans a fully and expensively equipped crew of cameramen. A high resolution static camera replaces the plural camera crew and their efficient camera movements are then simulated by virtually panning - tilting - zooming within the original recordings. We show that multiple virtual cameras can be simulated by choosing different trajectories of cropping windows inside the original recording. One of the key novelties of this work is an optimazation framework for computing the virtual camera trajectories using the information extracted from the original video based on computer vision techniques. The actors present on stage are considered as the most important elements of the scene. For the task of localizing and naming actors, we introduce generative models for learning view independent person and costume specific detectors from a set of labeled examples. We explain how to learn the models from a small number of labeled keyframes or video tracks, and how to detect novel appearances of the actors in a maximum likelihood framework. We demonstrate that such actor specific models can accurately localize actors despite changes in view point and occlusions, and significantly improve the detection recall rates over generic detectors. The dissertation then presents an offline algorithm for tracking objects and actors in long video sequences using these actor specific models. Detections are first performed to independently select candidate locations of the actor/object in each frame of the video. The candidate detections are then combined into smooth trajectories in an optimization step minimizing a cost function accounting for false detections and occlusions. Using the actor tracks, we propose a framework for automatically generating multiple clips suitable for video editing by simulating pan-tilt-zoom camera movements within the frame of a single static camera. Our method requires only minimal user input to define the subject matter of each sub-clip. The composition of each sub-clip is automatically computed in a novel L1-norm optimization framework. Our approach encodes several common cinematographic practices into a single convex cost function minimization problem, resulting in aesthetically-pleasing sub-clips which can easily be edited together using off-the-shelf multi-clip video editing software.
A VMD interface for analyzing metadynamics and molecular dynamics simulations ✩

a Institut Químic de Sarrià (IQS), Laboratory of Biochemistry, Via Augusta, 390, Barcelona, ES 08017, Spain b Centre Européen de Calcul Atomique et Moléculaire (CECAM), Ecole Polytechnique Fédérale de Lausanne, BCH 4102, Lausanne, CH 1015, Switzerland c Max Planck Institute of Biophysics (MPIBP), Theoretical Molecular Biophysics, Max-von-Laue-Straße, 3, Frankfurt am Main, DE 60438, Germany d Scuola Internazionale Superiore di Studi Avanzati (SISSA), Via Bonomea, 265, Trieste, IT 34136, Italy