Miracle-dz/UniFAR-FTUs huggingface dataset:
Effectiveness of a Web-Based Simulation in Improving Nurses’ Workplace Practice With Deteriorating Ward Patients: A Pre- and Postintervention Study

Background Nurses play an important role in detecting patients with clinical deterioration. However, the problem of nurses failing to trigger deteriorating ward patients still persists despite the implementation of a patient safety initiative, the Rapid Response System. A Web-based simulation was developed to enhance nurses’ role in recognizing and responding to deteriorating patients. While studies have evaluated the effectiveness of the Web-based simulation on nurses’ clinical performance in a simulated environment, no study has examined its impact on nurses’ actual practice in the clinical setting. Objective The objective of this study was to evaluate the impact of Web-based simulation on nurses' recognition of and response to deteriorating patients in clinical settings. The outcomes were measured across all levels of Kirkpatrick’s 4-level evaluation model with clinical outcome on triggering rates of deteriorating patients as the primary outcome measure. Methods A before-and-after study was conducted on two general wards at an acute care tertiary hospital over a 14-month period. All nurses from the two study wards who undertook the Web-based simulation as part of their continuing nursing education were invited to complete questionnaires at various time points to measure their motivational reaction, knowledge, and perceived transfer of learning. Clinical records on cases triggered by ward nurses from the two study wards were evaluated for frequency and types of triggers over a period of 6 months pre- and 6 months postintervention. Results The number of deteriorating patients triggered by ward nurses in a medical general ward increased significantly (P<.001) from pre- (84/937, 8.96%) to postintervention (91/624, 14.58%). The nurses reported positively on the transfer of learning (mean 3.89, SD 0.49) from the Web-based simulation to clinical practice. A significant increase (P<.001) on knowledge posttest score from pretest score was also reported. The nurses also perceived positively their motivation (mean 3.78, SD 0.56) to engage in the Web-based simulation. Conclusions This study provides evidence on the effectiveness of Web-based simulation in improving nursing practice when recognizing and responding to deteriorating patients. This educational tool could be implemented by nurse educators worldwide to address the educational needs of a large group of hospital nurses responsible for patients in clinical deterioration.
Inhaled colistin in patients with bronchiectasis and chronic Pseudomonas aeruginosa infection.

RATIONALE Chronic infection with Pseudomonas aeruginosa is associated with an increased exacerbation frequency, a more rapid decline in lung function, and increased mortality in patients with bronchiectasis. OBJECTIVES To perform a randomized placebo-controlled study assessing the efficacy and safety of inhaled colistin in patients with bronchiectasis and chronic P. aeruginosa infection. METHODS Patients with bronchiectasis and chronic P. aeruginosa infection were enrolled within 21 days of completing a course of antipseudomonal antibiotics for an exacerbation. Participants were randomized to receive colistin (1 million IU; n = 73) or placebo (0.45% saline; n = 71) via the I-neb twice a day, for up to 6 months. MEASUREMENTS AND MAIN RESULTS The primary endpoint was time to exacerbation. Secondary endpoints included time to exacerbation based on adherence recorded by the I-neb, P. aeruginosa bacterial density, quality of life, and safety parameters. All analyses were on the intention-to-treat population. Median time (25% quartile) to exacerbation was 165 (42) versus 111 (52) days in the colistin and placebo groups, respectively (P = 0.11). In adherent patients (adherence quartiles 2-4), the median time to exacerbation was 168 (65) versus 103 (37) days in the colistin and placebo groups, respectively (P = 0.038). P. aeruginosa density was reduced after 4 (P = 0.001) and 12 weeks (P = 0.008) and the St. George's Respiratory Questionnaire total score was improved after 26 weeks (P = 0.006) in the colistin versus placebo patients, respectively. There were no safety concerns. CONCLUSIONS Although the primary endpoint was not reached, this study shows that inhaled colistin is a safe and effective treatment in adherent patients with bronchiectasis and chronic P. aeruginosa infection. Clinical trial registered with http://www.isrctn. org/ (ISRCTN49790596).
TECHNOLOGY WEIGHT LOSS CORROSION STUDIES OF ALUMINIUM-7075 ALLOY REINFORCED WITH SILICON CARBIDE PARTICULATES COMPOSITES IN ACID CHLORIDE MEDIUM

The aim of the research work to investigate the corrosion behaviour of Silicon Carbide(SiC) reinforced aluminium 7075 metalmatrix composites (MMCs) in acid chloride solution using weight loss method. The composites are manufactured by liquid metallurgy technique using vortex method. Aluminium 7075 / SiC MMCs containing 2, 4 and 6 weight percentage of SiC particulates are casted. The corrosion characteristics of Aluminium 7075 /SiCcomposite and the unreinforced alloy were experimentally assessed. The corrosion test was carried out at different concentrations of 0.025M, 0.05M and 0.1 M solutions for different exposure time. The results indicated that corrosion rate of metal matrix composites was lower than that of matrix material Al 7075 under the corrosive atmosphere irrespective of exposure time and concentration of corrodent. Aluminium 7075 / SiC composite become more corrosion resistant as the SiC content is increased. This is because of the formation of stable oxide layer over the specimens.
Impact of a Problem-Based Learning (PBL) Health Literacy Program on Immigrant Women’s Health Literacy, Health Empowerment, Navigation Efficacy, and Health Care Utilization

We evaluated the effectiveness of a problem-based learning (PBL) health literacy program aimed to improve health literacy, health empowerment, navigation efficacy, and health care utilization among immigrant women in Taiwan. We employed a quasi-experimental design that included surveys at the baseline, immediately after the intervention, and 6 months after the intervention. The intervention group participated in a 10-session PBL health literacy program and the comparison group did not. Results showed that 6 months after the intervention, the intervention group had significantly fewer ER visits and hospitalizations than the comparison group. The intervention group reported a greater decrease in delaying/avoiding health care due to communication barriers. Although the intervention group showed improvement in health literacy, health empowerment and navigation self-efficacy, the differences were not statistically significant. The PBL health literacy program resulted in fewer ER visits and hospitalizations, and better health care access among immigrant women. Cognitive and psychological outcomes examined in the study appeared more difficult to change. The PBL health literacy program effectively improved health care utilization and reduced barriers to health care access among immigrant women in Taiwan. It would be useful to examine the effectiveness of the program in other populations.
Differential evolution enhanced with evolution path vector

In order to combine the advantages of distributed model (DM) and centralized model (CM) offspring generation models, this paper proposes to use the differential evolution (DE) algorithm as the base population reproduction method and enhance its DM scheme with one of the key CM features, which is the covariance matrix adaptation (CMA) used in CMA-ES. In this way, an enhanced DE population reproduction scheme with evolution path (DE/EP) is developed. The proposed DE/EP scheme is kept almost as simple as the original DE but works better due to the advantages of the CMA feature.
Kinetics of antibodies against pneumococcal proteins and their relationship to nasopharyngeal carriage in the first two months of life

Introduction The currently used Streptococcus pneumoniae vaccines have had a significant impact on the pneumococcal diseases caused by the serotypes they cover. Their limitations have stimulated a search for alternate vaccines that will cover all serotypes, be affordable and effective in young children. Pneumococcal protein antigens are potential vaccine candidates that may meet some of the shortfalls of the current vaccines. Thus, this study aimed to determine the relationship between antibodies against pneumococcal protein antigens and nasopharyngeal carriage in infants. Methods One hundred and twenty mother-infant pairs were enrolled into the study. They had nasopharyngeal swabs(NPS) taken at birth and every two weeks for the first eight weeks after delivery, and blood samples were obtained at birth and every four weeks for the first eight weeks after delivery. Nasopharyngeal carriage of S. pneumoniae was determined from the NPS and antibodies against the pneumococcal proteins CbpA, PspA and rPly were measured in the blood samples. Results The S. pneumoniae carriage rate in infants increased to that of mothers by eight weeks of age. The odds of carriage in infants was 6.2 times (95% CI: 2.0–18.9) higher when their mothers were also carriers. Bacterial density in infants was lower at birth compared to their mothers (p = 0.004), but increased with age and became higher than that of their mothers at weeks 4 (p = 0.009), 6 (p = 0.002) and 8 (p<0.0001). At birth, the infants’ antibodies against CbpA, and rPly pneumococcal protein antigens were similar, but that of PspA was lower (p<0.0001), compared to their mothers. Higher antibody concentrations to CbpA [OR (95% CI): 0.49 (0.26–0.92, p = 0.03)], but not PspA and rPly, were associated with protection against carriage in the infants. Conclusion Naturally induced antibodies against the three pneumococcal protein antigens were transferred from mother to child. The proportion of infants with nasopharyngeal carriage and the bacterial density of S. pneumoniae increased with age within the first eight weeks of life. Higher concentrations of antibodies against CbpA, but not PspA and rPly, were associated with reduced risk of nasopharyngeal carriage of S. pneumoniae in infants.
A Multifoci Person-Centered Perspective on Workplace Affective Commitment: A Latent Profile/Factor Mixture Analysis

The current study aims to explore the usefulness of a person-centered perspective to the study of workplace affective commitment (WAC). Five distinct profiles of employees were hypothesized based on their levels of WAC directed toward seven foci (organization, workgroup, supervisor, customers, job, work, and career). This study applied latent profile analyses and factor mixture analyses to a sample of 404 Canadian workers. The construct validity of the extracted latent profiles was verified by their associations with multiple predictors (gender, age, tenure, social relationships at work, workplace satisfaction, and organizational justice perceptions) and outcomes (in-role performance, organizational citizenship behaviors, and intent to quit). The analyses confirmed that a model with five latent profiles adequately represented the data: (a) highly committed toward all foci; (b) weakly committed toward all foci; (c) committed to their supervisor and moderately committed to the other foci; and (d) committed to their career and moderately uncommitted to the other foci; (e) committed mostly to their proximal work environment. These latent profiles present theoretically coherent patterns of associations with the predictors and outcomes, which suggests their adequate construct validity.
Employing Computers for the Recruitment into Clinical Trials: A Comprehensive Systematic Review

Background Medical progress depends on the evaluation of new diagnostic and therapeutic interventions within clinical trials. Clinical trial recruitment support systems (CTRSS) aim to improve the recruitment process in terms of effectiveness and efficiency. Objective The goals were to (1) create an overview of all CTRSS reported until the end of 2013, (2) find and describe similarities in design, (3) theorize on the reasons for different approaches, and (4) examine whether projects were able to illustrate the impact of CTRSS. Methods We searched PubMed titles, abstracts, and keywords for terms related to CTRSS research. Query results were classified according to clinical context, workflow integration, knowledge and data sources, reasoning algorithm, and outcome. Results A total of 101 papers on 79 different systems were found. Most lacked details in one or more categories. There were 3 different CTRSS that dominated: (1) systems for the retrospective identification of trial participants based on existing clinical data, typically through Structured Query Language (SQL) queries on relational databases, (2) systems that monitored the appearance of a key event of an existing health information technology component in which the occurrence of the event caused a comprehensive eligibility test for a patient or was directly communicated to the researcher, and (3) independent systems that required a user to enter patient data into an interface to trigger an eligibility assessment. Although the treating physician was required to act for the patient in older systems, it is now becoming increasingly popular to offer this possibility directly to the patient. Conclusions Many CTRSS are designed to fit the existing infrastructure of a clinical care provider or the particularities of a trial. We conclude that the success of a CTRSS depends more on its successful workflow integration than on sophisticated reasoning and data processing algorithms. Furthermore, some of the most recent literature suggest that an increase in recruited patients and improvements in recruitment efficiency can be expected, although the former will depend on the error rate of the recruitment process being replaced. Finally, to increase the quality of future CTRSS reports, we propose a checklist of items that should be included.
Research on Preparation of High Temperature Resistant Abrasion Cr_3C_2-25%NiCr Coating and Mechanical Property

The resistant high temperature abrasion coating is prepared by high velocity oxygen fuel sprayed spheroid sintered Cr_3C_2-25%NiCr composite powder.Microscopic structure of powder and coating are researched through scanning electronic microscope(SEM). Image processing software is used to analysis porosity of coating.Bond strength and surface hardness of coating and friction wear testing are carried out to measure coating's mechanical property.Results indicate that sintering state of powder,chromium carbide size and powder size effect the mechanical property of coating.KF-70 coating have top of bond strength and surface hardness.
Influence of biological motion cues on collision avoidance temporal decision processing

This master proposal is a joint project with a PhD work about motion perception during collision avoidance task between walkers. The methodological approach considers virtual reality as a main tool to study human behaviour. One of the main task will be to develop new experiments in the existing VR setup. In addition, the candidate will be involved in the management of the experiment as well as the data analysis and interpretation.
Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease.

CONTEXT Increased dietary intake of marine omega-3 fatty acids is associated with prolonged survival in patients with coronary heart disease. However, the mechanisms underlying this protective effect are poorly understood. OBJECTIVE To investigate the association of omega-3 fatty acid blood levels with temporal changes in telomere length, an emerging marker of biological age. DESIGN, SETTING, AND PARTICIPANTS Prospective cohort study of 608 ambulatory outpatients in California with stable coronary artery disease recruited from the Heart and Soul Study between September 2000 and December 2002 and followed up to January 2009 (median, 6.0 years; range, 5.0-8.1 years). MAIN OUTCOME MEASURES We measured leukocyte telomere length at baseline and again after 5 years of follow-up. Multivariable linear and logistic regression models were used to investigate the association of baseline levels of omega-3 fatty acids (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA]) with subsequent change in telomere length. RESULTS Individuals in the lowest quartile of DHA+EPA experienced the fastest rate of telomere shortening (0.13 telomere-to-single-copy gene ratio [T/S] units over 5 years; 95% confidence interval [CI], 0.09-0.17), whereas those in the highest quartile experienced the slowest rate of telomere shortening (0.05 T/S units over 5 years; 95% CI, 0.02-0.08; P < .001 for linear trend across quartiles). Levels of DHA+EPA were associated with less telomere shortening before (unadjusted beta coefficient x 10(-3) = 0.06; 95% CI, 0.02-0.10) and after (adjusted beta coefficient x 10(-3) = 0.05; 95% CI, 0.01-0.08) sequential adjustment for established risk factors and potential confounders. Each 1-SD increase in DHA+EPA levels was associated with a 32% reduction in the odds of telomere shortening (adjusted odds ratio, 0.68; 95% CI, 0.47-0.98). CONCLUSION Among this cohort of patients with coronary artery disease, there was an inverse relationship between baseline blood levels of marine omega-3 fatty acids and the rate of telomere shortening over 5 years.
Paramecium jenningsi Species Complex (Ciliophora, Protista) in India: the First Description of New Stands of P. bijenningsi and P. trijenningsi

Paramecium jennngsi (Ciliophora, Protista) is a complex of three cryptic species known from 13 sampling points situated around the world, mainly in the tropics. Two strains recently collected in India were identified as P. bijenningsi and P. trijenningsi from the P. jenningsi complex, based on an analysis of 16 (both nuclear and mitochondrial) loci, strain crosses, and cytological analyses. Current results increase the knowledge about the species range of particular members of the P. jenningsi complex.
Satellite-like Gold Nanocomposites for Targeted Mass Spectrometry Imaging of Tumor Tissues

We have developed a simple, rapid, high-throughput cancer diagnosis system using functional nanoparticles (NPs) consisting of poly(catechin) capped-gold NPs (Au@PC NPs) and smaller nucleolin-binding aptamer (AS1411) conjugated gold NPs (AS1411-Au NPs). The AS1411-Au NPs/Au@PC NP is used as a targeting agent in laser desorption/ionization mass spectrometry (LDI-MS)-based tumor tissue imaging. Self-assembled core-shell Au@PC NPs are synthesized by a simple reaction of tetrachloroaurate(III) with catechin. Au@PC NPs with a well-defined and dense poly(catechin) shell (~40-60 nm) on the surface of each Au core (~60-80 nm) are obtained through careful control of the ratio of catechin to gold ions, as well as the pH of the reaction solution. Furthermore, we have shown that AS1411-conjugated Au NPs (13-nm) self-assembled on Au@PC NP can from a satellite-like gold nanocomposite. The high density of AS1411-Au NPs on the surface of Au@PC NP enhances multivalent binding with nucleolin molecules on tumor cell membranes. We have employed LDI-MS to detect AS1411-Au NPs/Au@PC NPs labeled nucleolin-overexpressing MCF-7 breast cancer cells through the monitoring of Au cluster ions ([Aun]+; 1 ≤ n ≤ 3). The ultrahigh signal amplification from Au NPs through the formation of a huge number of [Aun]+ ions results in a sensing platform with a limit of detection of 100 MCF-7 cells mL-1. Further, we have applied the satellite-like AS1411-Au NPs/Au@PC NP nanocomposite as a labeling agent for tumor tissue imaging by LDI-MS. Our nanocomposite-assisted LDI-MS imaging platform can be extended for simultaneous analysis of different tumor markers on cell membranes when using different ligand-modified metal nanoparticles.
Object decision test (BORB): normative data for the adult Quebec population and performance in Alzheimer’s disease and the semantic variant of primary progressive aphasia

ABSTRACT Object decision (OD) test is one subtest of the Birmingham Object Recognition Battery (BORB). It is useful for differential diagnosis among several neurodegenerative diseases. However, normative data provided with this battery count on very few subjects and do not control for the effect of age, which limits interpretability. The purpose of Study 1 was to provide normative data for the OD test of the BORB (version A—hard). The objectives of Study 2 were to establish the diagnostic validity of this task and predictive validity of the normative data in the case of the semantic variant of primary progressive aphasia (svPPA) and Alzheimer’s disease (AD). Based on multiple linear regressions, equations to calculate Z-scores corrected for age were provided for 130 participants aged from 47 to 89 years. Performance of 20 healthy participants was compared to that of 14 individuals with svPPA and 18 with AD. After controlling for confounders, participants with svPPA had a lower total score than controls and AD participants. AD participants had a poorer performance than controls only when chimeric objects were considered. Among those with a deficit on the total score of the test, 94% (17/18, including 12 with svPPA) were correctly identified as having a pathological condition (svPPA or AD). This test could help refine differential diagnosis between svPPA and AD patients, especially before the deficits of episodic memory show up.
Ammonia emissions from deciduous forest after leaf fall

The understanding of biochemical feedback mechanisms in the climate system is lacking knowledge in relation to bi-directional ammonia (NH3) exchange between natural ecosystems and the atmosphere. We therefore study the atmospheric NH3 fluxes during a 25-day period during autumn 2010 (21 October to 15 November) for the Danish beech forest Lille Bogeskov to address the hypothesis that NH3 emissions occur from deciduous forests in relation to leaf fall. This is accomplished by using observations of vegetation status, NH3 fluxes and model calculations. Vegetation status was observed using plant area index (PAI) and leaf area index (LAI). NH3 fluxes were measured using the relaxed eddy accumulation (REA) method. The REA-based NH3 concentrations were compared to NH3 denuder measurements. Model calculations of the atmospheric NH3 concentration were obtained with the Danish Ammonia MOdelling System (DAMOS). The relative contribution from the forest components to the atmospheric NH3 flux was assessed using a simple two-layer bi-directional canopy compensation point model. A total of 57.7% of the fluxes measured showed emission and 19.5% showed deposition. A clear tendency of the flux going from deposition of −0.25 ± 0.30 μg NH3-N m−2 s−1 to emission of up to 0.67 ± 0.28 μg NH3-N m−2 s−1 throughout the measurement period was found. In the leaf fall period (23 October to 8 November), an increase in the atmospheric NH3 concentrations was related to the increasing forest NH3 flux. Following leaf fall, the magnitude and temporal structure of the measured NH3 emission fluxes could be adequately reproduced with the bi-directional resistance model; it suggested the forest ground layer (soil and litter) to be the main contributing component to the NH3 emissions. The modelled concentration from DAMOS fits well the measured concentrations before leaf fall, but during and after leaf fall, the modelled concentrations are too low. The results indicate that the missing contribution to atmospheric NH3 concentration from vegetative surfaces related to leaf fall are of a relatively large magnitude. We therefore conclude that emissions from deciduous forests are important to include in model calculations of atmospheric NH3 for forest ecosystems. Finally, diurnal variations in the measured NH3 concentrations were related to meteorological conditions, forest phenology and the spatial distribution of local anthropogenic NH3 sources. This suggests that an accurate description of ammonia fluxes over forest ecosystems requires a dynamic description of atmospheric and vegetation processes.