Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of cellular and viral factors related to anti‐hepatitis C virus activity of cyclophilin inhibitor

We have so far reported that an immunosuppressant cyclosporin A (CsA), a well‐known cyclophilin (CyP) inhibitor (CPI), strongly suppressed hepatitis C virus (HCV) replication in cell culture, and that CyPB was a cellular cofactor for viral replication. To further investigate antiviral mechanisms of CPI, we here developed cells carrying CsA‐resistant HCV replicons, by culturing the HCV subgenomic replicon cells for 4 weeks in the presence of CsA with G418. Transfection of total RNA from the isolated CsA‐resistant cells to naïve Huh7 cells conferred CsA resistance, suggesting that the replicon RNA itself was responsible for the resistant phenotype. Of the identified amino acid mutations, D320E in NS5A conferred the CsA resistance. The replicon carrying the D320E mutation was sensitive to interferon‐α, but was resistant to CsA and other CPIs including NIM811 and sanglifehrin A. Knockdown of individual CyP subtypes revealed CyP40, in addition to CyPA and CyPB, contributed to viral replication, and CsA‐resistant replicons acquired independence from CyPA for efficient replication. These data provide important evidence on the mechanisms underlying the regulation of HCV replication by CyP and for designing novel and specific anti‐HCV strategies with CPIs. (Cancer Sci 2009; 100: 1943–1950)
Design and validation of innovative integrated circuits and embedded systems for neurostimulation applications

La bioelectronique est un domaine interdisciplinaire qui etudie les interconnexions et les interactions entre entites biologiques (cellules, tissus, organes) et systemes electroniques,par l’intermediaire du transducteur adequat. Pour des cellules ou des tissus excitables (neurones, muscles, .), le transducteur prend la forme d’une simple electrode, car ces tissus produisent une activite electrique spontanee ou, dans le sens inverse, peuvent etre excites par un signal electrique externe. Cette communication bidirectionnelle donne lieu a deux schemas experimentaux : l’acquisition et la stimulation. L’acquisition consiste a enregistrer, traiter et analyser les bio-signaux alors que la stimulation consiste a appliquer le courant electrique adequat aux tissus vivants, pour declencher une reaction. Cette these se concentre sur ce dernier point : deux generations de systeme de stimulation ont ete developpees, chacune basee sur un circuit integre specifique et adaptee a differents contextes applicatifs.Tout d’abord, le cadre scientifique a ete celui du projet CENAVEX, axe sur la stimulation electrique fonctionnelle pour rehabiliter la fonction respiratoire, suite a une lesion de la moelle epiniere. Ensuite, les objectifs de conception ont ete etendus pour couvrir de nouveaux besoins d’application : la surveillance de l’impedance electrique in situ et l’exploration des formes d’onde de stimulation originales. Le premier pourrait etre une solution pour suivre la reaction tissulaire apres l’implantation d’une electrode, contribuant ainsi a la biocompatibilite a long terme des implants ; le second propose d’aller au-dela dela conventionnelle impulsion biphasique carree et d’explorer de nouvelles formes d’ondes qui pourraient etre plus efficaces en termes de consommation d’energie, pour un effet physiologique donne.Le travail presente dans ce manuscrit contribue a la conception, a la fabrication et au test de dispositifs de stimulation innovants. Cela a conduit au developpement de deux circuits integres et de deux dispositifs de stimulation permettant une stimulation multicanal.Les caracterisations electriques et les validations biologiques, de la faisabilite in vitro aux experiences in vivo, ont ete menees et sont decrites dans ce manuscrit.
Clinical study of the effects of latissimus dorsi muscle flap stimulation after cardiomyoplasty.

BACKGROUND Beneficial hemodynamic effects after dynamic cardiomyoplasty have been inconsistently demonstrated, and the effects seen may be due to the wrap itself, to flap stimulation, or both. The aim of this study was to determine whether flap stimulation per se acts as a systolic active process after cardiomyoplasty. METHODS AND RESULTS Catheterizations were performed in 13 patients 14.4 +/- 7 months after cardiomyoplasty. New York Heart Association functional class decreased from 3.3 to 2.1 after the procedure (P = .0005). Hemodynamic evaluations were first performed with the stimulator on in the 2:1 mode and then after the stimulator had been off for at least 24 hours. Left ventricular (LV) ejection fraction increased from 25.1 +/- 6% before surgery to 28.2 +/- 6.7% with the stimulator on after cardiomyoplasty (P = .04). When stimulation was stopped, there was no change (P > .05) in indexes of systolic or diastolic LV function (peak systolic LV pressure, LV ejection fraction, peak positive dP/dt, peak negative dP/dt, or tau). Pulmonary capillary wedge pressure and cardiac index were unchanged when stimulated and nonstimulated settings were compared (P > .05). However, a remarkable heterogeneity of individual responses was observed. Ejection fraction and cardiac index decreased with the stimulator off in 3 patients, but peak positive dP/dt decreased in 6 patients; diastolic function deteriorated in 2 patients, but a slight improvement was noted in 3 patients. Cardiothoracic ratio, echocardiographic LV end-diastolic dimension, and fractional shortening remained unchanged between immediate (< 1 month) and long-term (36.7 +/- 25.9 months) postoperative evaluations. CONCLUSIONS In the majority of our patients, there was no short-term hemodynamic benefit of flap stimulation; therefore, we conclude that the efficacy of cardiomyoplasty may be a consequence of a passive "girdling effect," which limits the progression of ventricular enlargement and further deterioration of ejection fraction.
Offline-provisioning and Synchronization of Content for Mobile Webapps

Despite progress in the development of cross-platform frameworks, today’s apps often are realized either as native apps or as Webapps. The latter are easy to implement and rely on robust and future-proof technologies such as HTML5, Cascading Style Sheets (CSS) and JavaScript. However, Webapps commonly require a stable Internet connection. Recent developments facilitate offline-enabled Webapps. If an app is able to store data locally, it should also be enabled to synchronize with a server backend. We assess current HTML5 storage capabilities and discuss their possibilities along with considerations of mobile computing synchronization strategies. Our work includes the compilation of requirements that Webapps have regarding their offline capabilities. Moreover, we discuss the status quo of offline storage and give an outlook based on a proof-ofconcept implementation.
Scalability of dense wireless lighting control networks

In modern lighting systems, the introduction of wirelessly controlled LED light sources leads to very dense wireless lighting networks. Current approaches for control message transmission are based on broadcasting messages among many luminaires. However, adequate communication performance - in particular, sufficiently low latency and synchronicity - is difficult to ensure in such networks, especially if the network is part of a wireless building management system and carries not only low-latency broadcast messages but also collects data from sensors. This article describes the challenge of dense wireless lighting control networks. In particular, it discusses the underlying mechanisms and refers to current wireless sensor network solutions in which scalability is relevant.
Ptosis Surgery in Patients with Myasthenia Gravis: A Useful Adjunct to Medical Therapy

ABSTRACT Introduction: Medical management can have limitations in improving ptosis in patients with myasthenia gravis (MG). We present our experience of ptosis surgery in MG. Materials and Methods: Clinical records of all patients with MG undergoing ptosis surgery from September 2007 to November 2013 in a single center were retrospectively reviewed. Change in upper marginal reflex distance (uMRD) was the main outcome measure. Results: Sixteen external levator advancement (ELA) procedures were performed on 11 MG patients. Fourteen of 16 procedures had pre- and postoperative uMRD documented. Thirteen of 14 procedures had improved lid height; mean increase in uMRD was 2.4 mm (P=0.0005651). Two patients required secondary lid elevation. Postoperative complications included more noticeable diplopia (n=1) and exposure keratopathy (n=1). Conclusion: Ptosis surgery is a useful adjunct to medical therapy to improve lid height in MG patients with ptosis. Risks of diplopia and exposure keratopathy should be discussed with the patient pre-operatively.
Phrenic long‐term facilitation requires NMDA receptors in the phrenic motonucleus in rats

Exposure to episodic hypoxia induces a persistent augmentation of respiratory activity, known as long‐term facilitation (LTF). LTF of phrenic nerve activity has been reported to require serotonin receptor activation and protein syntheses. However, the underlying cellular mechanism still remains poorly understood. NMDA receptors play key roles in synaptic plasticity (e.g. some forms of hippocampal long‐term potentiation). The present study was designed to examine the role of NMDA receptors in phrenic LTF and test if the relevant receptors are located in the phrenic motonucleus. Integrated phrenic nerve activity was measured in anaesthetized, vagotomized, neuromuscularly blocked and artificially ventilated rats before, during and after three episodes of 5 min isocapnic hypoxia (Pa,O2= 30–45 mmHg), separated by 5 min hyperoxia (50% O2). Either saline (as control) or the NMDA receptor antagonist MK‐801 (0.2 mg kg−1, i.p.) was systemically injected ∼1 h before hypoxia. Phrenic LTF was eliminated by the MK‐801 injection (vehicle, 32.8 ± 3.7% above baseline in phrenic amplitude at 60 min post‐hypoxia; MK‐801, −0.5 ± 4.1%, means ±s.e.m.), with little change in both the CO2‐apnoeic threshold and the hypoxic phrenic response (HPR). Vehicle (saline, 5 × 100 nl) or MK‐801 (10 μm; 5 × 100 nl) was also microinjected into the phrenic motonucleus region in other groups. Phrenic LTF was eliminated by the MK‐801 microinjection (vehicle, 34.2 ± 3.4%; MK‐801, −2.5 ± 2.8%), with minimal change in HPR. Collectively, these results suggest that the activation of NMDA receptors in the phrenic motonucleus is required for the episodic hypoxia‐induced phrenic LTF.
Regulation of c‐jun mRNA expression in adult cardiocytes by MAP kinase interacting kinase‐1 (MNK1)

Hypertrophic growth of adult myocardium is associated with increased expression of theearly response gene c‐jun. The purpose of this study was to determine whether eukaryotic initiation factor (elF)4E (eIF4E) regulates translational efficiency of c‐jun mRNA as measured by flux into polysomes. Adult feline cardiomyocytes in primary culture were treated with 0.2 µM 12‐O‐tetradecanoylphorbol 13‐acetate (TPA), and c‐jun mRNA was quantified in total, monosome, andpolysome fractions by real‐time polymerase chain reaction. After 1 h, TPA increased total c‐jun mRNA by 10.5‐fold. The corresponding flux into polysomes was significantly lower (5‐fold). Adenoviral‐mediated overexpression of either eIF4E or a nonphosphorylatable mutant (S209/A) did not affect total c‐jun mRNA or its flux between monosomes and polysomes. Similar results were obtained following overexpression of the eIF4E kinase Mnk1. Thus, translational efficiency of c‐jun mRNA was not affected by changes in activity ore amount of eIF4E. In contrast, a kinase‐deficient Mnk1 mutant significantly reduced total c‐jun mRNA from 9.8‐fold to 6.0‐fold while flux between monosomes and polysomes remained constant. The decrease in total c‐jun mRNA resulted from increased decay of c‐jun mRNA incorporated into the polysomes. We conclude that Mnk1 activity stabilizes c‐jun mRNA in polysomes independent of eIF4E phosphorylation. ‐Spruill, L. McDermott, P. Regulation of c‐jun mRNA expression in adult cardiocytes by MAP kinase interacting kinase‐1 (MNK1). FASEB J. 20, E1465‐E1475 (2006)
A comparison of the long-term functional outcomes of standard pancreatoduodenectomy and pylorus-preserving pancreatoduodenectomy.

BACKGROUND/AIMS We compared the long-term functional outcomes of standard pancreatoduodenectomy (SPD) and pylorus-preserving pancreatoduodenectomy (PPPD) patients. METHODOLOGY The subjects were 67 patients who underwent SPD (23) or PPPD (44) and who survived more than 3 years. General nutritional status, pancreatic functions, gastrointestinal (GI) symptoms, and quality of life (QOL) were assessed. RESULTS Postoperative relative body weights to preoperative body weight in the SPD group were generally lower, however, no significant difference was observed throughout the postoperative period, except at 6 postoperative months. Steatorrhea developed in 3 (13.0%) of the 23 SPD and in 6 (13.6%) of the 44 PPPD patients during the 3-year follow-up (p > 0.05). IFG or DM newly developed in 2 (10.5%) of the 19 SPD and in 5 (13.9%) of the 36 PPPD patients during the 3-year follow-up (p > 0.05). Symptoms such as flatus, diarrhea and fatigue were more frequently observed in SPD patients. The general health status/QOL score of the PPPD group (75.5) was somewhat higher than that of the SPD group (65.4) (p > 0.05). CONCLUSIONS The long-term functional outcomes of SPD and PPPD patients were generally comparable. However, PPPD was more favorable than SPD in terms of an earlier postoperative recovery and reduced rates of GI symptoms such as flatus and diarrhea.
Identification of Seoul Hantavirus in Rattus norvegicus in Indonesia

The first genetic evidence for the presence of Seoul hantavirus (SEOV) in Indonesia is presented. Partial M segment sequence was recovered from the lung tissue of Rattus norvegicus trapped in central Jakarta. The sequence belongs to SEOV genotype and is most closely related to the strain B-1 from Japan.
Why Paul’s Fabulous Body is Missing its Belly: The Rhetorical Subversion of Menenius Agrippa’s Fable in 1 Corinthians 12.12-30 1

In 1 Cor. 12.12-30, Paul addresses factionalism in Corinth by rhetorically reworking the famed fable of the Members and the Belly. Whereas historiographical narratives typically depict Menenius Agrippa using this fable about talking body parts to restore the status quo of plebeian submission, Paul uses certain elements of the fable to make his disruptive case for unity among the Corinthians. Paul’s subversive embellishment of the fable excises the belly, which plays a central role in the older tale. Other Pauline discussions of the ancient belly help to make sense of this surprising surgical move, one of Paul’s many rhetorical maneuvers that are aligned with the prescriptions found in ancient handbooks of preliminary exercises, or προγυμνάσματα.
Virtual Speaking Head for Hearing Impaired Students

Developed tool is one of system tools for easier access to various scientific areas and real time interactive learning between lecturer and for hearing impaired students. There is no demand for the lecturer to know Sign Language (SL). Instead, the new software tools will perform the translation of the regular speech into SL, after which it will be transferred to the student. On the other side, the questions of the student (in SL) will be translated and transferred to the lecturer in text or speech. One of those tools is presented tool. It’s too for developing the correct Speech Visemes as a root of total communication method for hearing impared students. Keywords—Impared people, sing language, communication methods.
Examination of the Relationship between Perfectionism Scores and Anger States in Physical Education and Sports Teacher Candidates

This study examined the relationship between perfectionism and anger states of Physical Education and Sports Teacher candidates (PESTC), and whether or not perfectionism sub-dimension scores were predictive of anger scores. A total of 130 students were participated. The Multidimensional Perfectionism Scale and The State-Trait Anger Scale were used to determine the perfectionism and anger states. Pearson Product-Moment Correlation Analysis results indicated that a positive significant relationship between socially prescribed perfectionism and the anger subscales state anger, anger-in and anger-out, while a negative significant relationship was found between socially prescribed perfectionism and anger-control. Additionally, Multi-Directional Regression Analysis results revealed that only socially prescribed perfectionism predicts anger subscale scores were at a significant level. Self-oriented and other-oriented perfectionism were not found to be significant in the prediction of anger subscales. In conclusion, the perfectionism as a personality character for PESTC should not be result in anger behavior during physical education processes.
Skin cancer in epidermodysplasia verruciformis patients from Brazil

1154 JEADV 2006, 20, 1133–1167 © 2006 European Academy of Dermatology and Venereology 3 median longitudinal onychorrhexis; and 4 subungual erythema. These alterations may be attributed to excessive employment of the nail file, resulting in profound thinning of the nail plate. Most of the patients were women, fearful of loosing their nail due to onychomycosis. Nail dystrophies of mechanical aetiology are frequently self-inflicted, and have been occasionally associated in literature with obsessive–compulsive disorders. Instructions to stop the nail trimming and subsequent follow-up of three patients resulted in complete reconstitution of nail morphology, within 6 months, in all nails affected. Therefore, we would like to draw attention to these distinct nail alterations, after the misuse of the nail file, in patients undergoing therapy for onychomycosis with antifungal nail lacquers and suggest the term ‘lacquer nail’ to describe the tetrad of features described above.
Improbable Creativity

We begin with a number of basic facts about creativity and a brief history of the idea. These provide criteria that any deﬁnition of the term should meet and help guide us to a new deﬁnition of creativity . This deﬁnition is independent of cultural appropriateness or the perceived value of creative objects, ideas which have encumbered previous investigations. We brieﬂy defend our deﬁnition against some plausible objections and then explore the ways in which this new deﬁnition differs from alternative views, by improving upon them.
A new approach to On-line Mapping

Internet mapping and the widespread availability of mapping software are revolutionizing the world of cartography: anyone can now produce maps of many areas of the world. However, these tools typically only allow one to produce pictures, and the process undertaken to achieve these pictures is lost. We present a new approach to cartography in which maps are understood to be the visual representation of a multidimensional context, and the space being mapped is one such context. This approach to mapping – called intensional – allows the developers of maps to keep track of all the choices that are being made, whether visual, structural or sociohistorical, and to share these choices with others, in real-time. As a result, electronic maps become much more flexible and versatile, and much more supportive of speculative research.
Türkiye'de Terör Olaylarının Demokratik Açılım Süreci Perspektifinden İncelenmesi

Bu calismanin temel amaci, Turkiye'deki teror olaylarinin sonucu olarak ekonomik buyume, askeri harcama ve demokratik acilim degiskenleri arasinda uzun vadeli bir iliski olup olmadigini arastirmaktir. Bu baglamda, calismada 1970-2015 donemleri icin zaman serisi analizi kullanilmistir. Bulgulara gore, demokratik acilimlarin teror saldirilari uzerindeki etkisi kisa ve uzun vadede farklilik arz etmektedir. Diger bir ifadeyle, demokratik acilis paketinin ilanindan kisa bir sure sonra terorizm uzerinde olumlu bir etki yaratmistir. Yani, demokratik acilis paketinin ilanindan sonra, teror olaylari onemli olcude azalmistir. Fakat bu etki uzun vadede kaybolmustur. Bu sonuclar, ekonomik ve sosyal cozumlerin, terorist saldirilari azaltmak icin askeri kuvvetler harcamasindan (savunma harcamalari, askeri harcamalari vb.) daha etkili oldugunu gostermektedir.
Nocardia species as an etiologic agent in Parkinson's disease: serological testing in a case-control study

To test the hypothesis that Nocardia spp. may be an etiologic factor in Parkinson's disease (PD), we used a serodiagnostic panel to determine if PD patients had antibodies specific for Nocardia spp. To validate the serological test panel, sera from healthy volunteers and from patients with culture-proven nocardiosis (n = 307) were compared in part 1 of the study. The sensitivity of the panel was 88% for detection of culture-proven nocardial infections, and specificity was 85% (excluding cross-reactive leprosy cases). In part 2, no difference in seropositivity was found when PD patients were compared with their age- and gender-matched controls (n = 140). We found a high exposure rate of humans to nocardial antigens, especially among men and older individuals. Our results offer no support to the hypothesis that Nocardia spp. are causative in PD; however, it is possible that serological testing may not be optimal for detection of nocardial central nervous system infection.
Performance Evaluation of Prioritized Limited Processor-Sharing System

— We propose a novel prioritized limited processor-sharing (PS) rule and a simulation algorithm for the performance evaluation of this rule. The performance measures of practical interest are evaluated using this algorithm. Suppose that there are two classes and that an arriving (class-1 or class-2) request encounters n 1 class-1 and n 2 class-2 requests (including the arriving one) in a single-server system. According to the proposed rule, class-1 requests individually and simultaneously receive m / (m * n 1 + n 2 ) of the service-facility capacity, whereas class-2 requests receive 1 / (m * n 1 + n 2 ) of it, if m * n 1 + n 2 ≤ C. Otherwise (m * n 1 + n 2 > C), the arriving request will be queued in the corresponding class waiting room or rejected. Here, m ( (cid:1) 1) denotes the priority ratio, and C ( (cid:2) ∞ ), the service-facility capacity. In this rule, when a request arrives at [or departs from] the system, the extension [shortening] of the remaining sojourn time of each request receiving service can be calculated using the number of requests of each class and the priority ratio. Employing a simulation program to execute these events and calculations enables us to analyze the performance of the proposed prioritized limited PS rule, which is realistic in a time-sharing system (TSS) with a sufficiently small time slot. Moreover, this simulation algorithm is expanded for the evaluation of the prioritized limited PS system with N (cid:1) 3 priority classes.
Comp Transmission in Cloud Radio Access Networks

Coordinated multi-point (CoMP) is an efficient technique to increase cell-edge coverage probability and throughput in cloud radio access network (C- RAN). In this paper, we develop a tractable framework to analytically evaluate the performance of two typical CoMP schemes, namely, zero-forcing beamforming(ZFBF) and non-coherent joint transmission (NC-JT). Using the stochastic geometry based approach, we characterize the signal-to- interference ratio (SIR) distribution at a typical downlink user. Furthermore, we consider the effect of imperfect channel state information (CSI) on coverage probability of the typical user from the practical design perspective. It is observed that ZFBF can outperform NC-JT only when there is sufficient overhead to convey the quantized CSI. In summary, this work serves as a good rule of thumb to compare the effect of CoMP techniques in C-RAN.