Miracle-dz/UniFAR-FTUs huggingface dataset:
Pengaruh Sistem Pengendalian Manajemen Terhadap Kreatifitas Manajer Dengan Motivasi Sebagai Variabel Intervening

This study aimed to determine (1) the effect of management control system on the creativity of manager, (2) the effect of self determination theoru of motivation on the relationship between management control system and creativity of manager. The subjects of this study are all managers in 48 (fouty-eight) Industrial forest company in Riau. The data was collected by distributing questionnaires to 144 respondents, but only 66 respondents fillout the questionnaires. The analysis done by using Partial Least Square (PLS) program version 3.2. 1 The results show that the system of management control and self-determination theory of motivation has significant effect on creativity of managers. Furthermore, The data of this study support the mediating role of self-determination theory of motivation on the relationship betweenmanagement control system and creativity of managers.
Reduction of BiP Levels Decreases Heterologous Protein Secretion in Saccharomyces cerevisiae(*)

Increased levels of the endoplasmic reticulum-resident protein folding chaperone BiP would be expected to either increase protein secretory capacity by improved solubilization of folding precursors or decrease secretory capacity by binding and retaining misfolded proteins. To address this question, the relationship between BiP levels and heterologous secretion in yeast was determined. A yeast strain was constructed in which BiP expression is tunable from 5 to 250% of wild-type levels, and this strain was used to explore the effect of varying BiP level on overall secretion of three heterologous proteins: human granulocyte colony-stimulating factor, Schizosaccharomyces pombe acid phosphatase, and bovine pancreatic trypsin inhibitor. For all three proteins examined, reduction in BiP expression below wild-type level diminished overall secretion, whereas 5-fold BiP overexpression from a constitutive glycolytic promoter did not substantially increase or decrease secretion titers. These results are consistent with a positive role for BiP in promoting membrane translocation and solubilization of folding precursors but are inconsistent with a negative role in proofreading and improper retention of heterologous secreted proteins.
A NOTE ON THE THAO PATIENT FOCUS PERFECTIVE

Le proto austronesien possede quatre affixes marquant un ensemble de relations grammaticales liees a la focalisation (focalisation instrumentale [FI], focalisation sur l'acteur [FA], focalisation locative [FL] et focalisation sur le patient [FP]). En outre, il possede un infixe -in- servant a marquer le temps passe ou l'aspect perfectif/imperfectif et pouvant etre utilise en meme temps que les affixes de FI, FA et FL. Lorsqu'il est utilise dans le cadre d'une focalisation sur le patient, la marque de la focalisation disparait et l'infixe prend alors une double fonction : celle du marquage de la focalisation et du perfectif. Dans cet article, l'A. se penche sur la particularite d'une langue austronesienne parlee a Taiwan, le thao, qui utilise doublement -in- dans un meme mot, pour marquer le perfectif et pour remplacer la marque de la focalisation sur le patient. Il tente notamment d'identifier les raisons qui ont motive cette evolution particuliere du thao
Site-directed mutagenesis of the cysteine ligands to the [4Fe-4S] cluster of Escherichia coli MutY.

The Escherichia coli DNA repair enzyme MutY plays an important role in the recognition and repair of 7, 8-dihydro-8-oxo-2'-deoxyguanosine:2'-deoxyadenosine (OG:A) mismatches in DNA [Michaels et al. (1992) Proc. Natl. Acad. Sci. U.S. A. 89, 7022-7025]. MutY prevents DNA mutations resulting from the misincorporation of A opposite OG by using N-glycosylase activity to remove the adenine base. An interesting feature of MutY is that it contains a [4Fe-4S]2+ cluster that has been shown to play an important role in substrate recognition [Porello, S. L. , Cannon, M. J., David, S. S. (1998) Biochemistry 37, 6465-6475]. Herein, we have used site-directed mutagenesis to individually replace the cysteine ligands to the [4Fe-4S]2+ cluster of E. coli MutY with serine, histidine, and alanine. The extent to which the various mutations reduce the levels of protein overexpression suggests that coordination of the [4Fe-4S]2+ cluster provides stability to MutY in vivo. The ability of the mutated enzymes to bind to a substrate analogue DNA duplex and their in vivo activity were evaluated. Remarkably, the effects are both substitution and position dependent. For example, replacement of cysteine 199 with histidine provides a mutated enzyme that is expressed at high levels and exhibits DNA binding and in vivo activity similar to the WT enzyme. These results suggest that histidine coordination to the iron-sulfur cluster may be accommodated at this position in MutY. In contrast, replacement of cysteine 192 with histidine results in less efficient DNA binding and in vivo activity compared to the WT enzyme without affecting levels of overexpression. The results from the site-directed mutagenesis suggest that the structural properties of the iron-sulfur cluster coordination domain are important for both substrate DNA recognition and the in vivo activity of MutY.
Epidemiologic study of relationships between consumption of commercial canned food and risk of hyperthyroidism in cats.

OBJECTIVE To determine whether the increasing prevalence of feline hyperthyroidism is the result of aging of the cat population and whether consumption of canned foods at various times throughout life is associated with increased risk of hyperthyroidism. DESIGN Retrospective and case-control studies. STUDY POPULATION Medical records of 169,576 cats, including 3,570 cats with hyperthyroidism, evaluated at 9 veterinary school hospitals during a 20-year period, and 109 cats with hyperthyroidism (cases) and 173 cats without hyperthyroidism (controls). PROCEDURE Age-adjusted hospital prevalence of hyperthyroidism was calculated by use of Veterinary Medical Database records. On the basis of owners' questionnaire responses, logistic regression was used to evaluate associations between consumption of canned food and development of hyperthyroidism. RESULTS Age-specific hospital prevalence of feline hyperthyroidism increased significantly from 1978 to 1997. Overall, consumption of pop-top canned (vs dry) food at various times throughout life and each additional year of age were associated with greater risk of developing hyperthyroidism. In female cats, increased risk was associated with consumption of food packaged in pop-top cans or in combinations of pop-top and non-pop-top cans. In male cats, increased risk was associated with consumption of food packaged in pop-top cans and age. CONCLUSIONS AND CLINICAL RELEVANCE These findings suggest that the increasing prevalence of feline hyperthyroidism is not solely the result of aging of the cat population and that canned foods may play a role.
The Human IL-3 Locus Is Regulated Cooperatively by Two NFAT-Dependent Enhancers That Have Distinct Tissue-Specific Activities1

The human IL-3 gene is expressed by activated T cells, mast cells, and eosinophils. We previously identified an enhancer 14 kb upstream of the IL-3 gene, but this element only functioned in a subset of T cells and not in mast cells. To identify additional mechanisms governing IL-3 gene expression, we mapped DNase I hypersensitive (DH) sites and evolutionarily conserved DNA sequences in the IL-3 locus. The most conserved sequence lies 4.5 kb upstream of the IL-3 gene and it encompassed an inducible cyclosporin A-sensitive DH site. A 245-bp fragment spanning this DH site functioned as a cyclosporin A-sensitive enhancer, and was induced by calcium and kinase signaling pathways in both T cells and mast cells via an array of three NFAT sites. The enhancer also encompassed AML1, AP-1, and Sp1 binding sites that potentially mediate function in both T and myeloid lineage cells, but these sites were not required for in vitro enhancer function in T cells. In stably transfected T cells, the −4.5-kb enhancer cooperated with the −14-kb enhancer to activate the IL-3 promoter. Hence, the IL-3 gene is regulated by two enhancers that have distinct but overlapping tissue specificities. We also identified a prominent constitutive DH site at −4.1 kb in T cells, mast cells, and CD34+ myeloid cells. This element lacked in vitro enhancer function, but may have a developmental role because it appears to be the first DH site to exist upstream of the IL-3 gene during hemopoietic development before IL-3 expression.
TETRASPANINs in Plants

Tetraspanins are small transmembrane proteins that laterally associate with each other and cluster with numerous partner proteins as well as lipids. These interactions result in the formation of a distinct class of membrane domains, the tetraspanin-enriched microdomains (TEMs), which influence numerous cellular processes such as cell adhesion and fusion, intracellular membrane trafficking, signaling, morphogenesis, motility as well as interaction with pathogens and cancer development. The majority of information available about tetraspanins is based on studies using animal models or cell lines, but tetraspanins are also present in fungi and plants. Recent studies indicate that tetraspanins have important functions in plant development, reproduction and stress responses. Here we provide a brief summary of the current state of tetraspanin research in plants.
A hybrid algorithm for efficient Wireless Sensor Network time synchronization

Applications of Wireless Sensor Networks (WSNs) have increased significantly in the last few decades and real time needs have to be satisfied using appropriate time synchronization algorithms. Novel synchronization algorithms can lead to improved network performance including energy consumption, throughput, and delay. This paper proposes, implements and evaluates a hybrid synchronization algorithm, to achieve performance efficient clock accuracy in cluster-based WSNs. The algorithm uses tight synchronization for inter-cluster communication and loose synchronization for intra-cluster communication. These distinctive features of the proposed hybrid algorithm make it performance-efficient for maintaining synchronization during time division multiple accesses (TDMA) scheduling. The results show reduced synchronization errors and delay with improved energy efficiency and throughput.
The cystic fibrosis lower airways microbial metagenome

Chronic airway infections determine most morbidity in people with cystic fibrosis (CF). Herein, we present unbiased quantitative data about the frequency and abundance of DNA viruses, archaea, bacteria, moulds and fungi in CF lower airways. Induced sputa were collected on several occasions from children, adolescents and adults with CF. Deep sputum metagenome sequencing identified, on average, approximately 10 DNA viruses or fungi and several hundred bacterial taxa. The metagenome of a CF patient was typically found to be made up of an individual signature of multiple, lowly abundant species superimposed by few disease-associated pathogens, such as Pseudomonas aeruginosa and Staphylococcus aureus, as major components. The host-associated signatures ranged from inconspicuous polymicrobial communities in healthy subjects to low-complexity microbiomes dominated by the typical CF pathogens in patients with advanced lung disease. The DNA virus community in CF lungs mainly consisted of phages and occasionally of human pathogens, such as adeno- and herpesviruses. The S. aureus and P. aeruginosa populations were composed of one major and numerous minor clone types. The rare clones constitute a low copy genetic resource that could rapidly expand as a response to habitat alterations, such as antimicrobial chemotherapy or invasion of novel microbes. The CF lung metagenome is composed of few viruses and fungi and hundreds of bacterial species, clones and subclones http://ow.ly/ZiqUE
Studies on the Mechanism of Action of Nalidixic Acid

With three independent techniques (absorption spectrophotometry, measurement of the deoxyribonucleic acid [DNA] melting temperature, and equilibrium dialysis), no evidence has been found for the binding of nalidixic acid to purified DNA. Also, no evidence has been found to support the hypothesis that nalidixic acid is permanently modified to a new, active compound by the bacterial cell. By using an in vitro DNA replication system developed by Bonhoeffer and colleagues, soluble extracts from nalidixic acid-sensitive cells have been shown to confer nalidixic acid sensitivity on the DNA synthesis of lysates from nalidixic acid-resistant cells. The activity in the extracts is only present in sensitive cells and is nondialyzable and heat sensitive. Finally, two known nalidixic acid-resistant mutants of Escherichia coli, mapping at nal A and nal B, respectively, have been tested to determine whether either of them is a transport mutant. It has been shown that nal Br is a transport mutant whereas nal Ar is not.
Automated feature extraction for early detection of diabetic retinopathy in fundus images

Automated detection of lesions in retinal images can assist in early diagnosis and screening of a common disease: Diabetic Retinopathy. A robust and computationally efficient approach for the localization of the different features and lesions in a fundus retinal image is presented in this paper. Since many features have common intensity properties, geometric features and correlations are used to distinguish between them. We propose a new constraint for optic disk detection where we first detect the major blood vessels and use the intersection of these to find the approximate location of the optic disk. This is further localized using color properties. We also show that many of the features such as the blood vessels, exudates and microaneurysms and hemorrhages can be detected quite accurately using different morphological operations applied appropriately. Extensive evaluation of the algorithm on a database of 516 images with varied contrast, illumination and disease stages yields 97.1% success rate for optic disk localization, a sensitivity and specificity of 95.7%and 94.2%respectively for exudate detection and 95.1% and 90.5% for microaneurysm/hemorrhage detection. These compare very favorably with existing systems and promise real deployment of these systems.
Dynamic clustering and sleep mode strategies for small cell networks

In this paper, a novel cluster-based approach for optimizing the energy efficiency of wireless small cell networks is proposed. A dynamic mechanism based on the spectral clustering technique is proposed to dynamically form clusters of small cell base stations. Such clustering enables intra-cluster coordination among the base stations for optimizing the downlink performance through load balancing, while satisfying users' quality-of-service requirements. In the proposed approach, the clusters use an opportunistic base station sleep-wake switching mechanism to strike a balance between delay and energy consumption. The inter-cluster interference affects the performance of the clusters and their choices of active or sleep state. Due to the lack of inter-cluster communications, the clusters have to compete with each other to make decisions on improving the energy efficiency. This competition is formulated as a noncooperative game among the clusters that seek to minimize a cost function which captures the tradeoff between energy expenditure and load. To solve this game, a distributed learning algorithm is proposed using which the clusters autonomously choose their optimal transmission strategies. Simulation results show that the proposed approach yields significant performance gains in terms of reduced energy expenditures up to 40% and reduced load up to 23% compared to conventional approaches.
Computer-Mediated Social Ties as Predictors of SNS Usage Continuance

The present article is a multi-method work in progress about the post-adoption phase of information systems, and more specifically it investigates the usage continuance of Social Networking Sites (SNS). We use the theoretical framework of Gift Theory applied within the context of SNS. We define the concept of computer-mediated social tie (CMST). In our work we use both qualitative and quantitative data and methods. From our qualitative data we found that CMST explains SNS usage continuance. Using these qualitative data we developed scales for this new construct. We are currently collecting quantitative data in order to verify our qualitative findings. We expect results to confirm the linkage between CMST and usage continuance.
Diffusion equations with negentropy applied to denoise mammographic images

Mammography is a radiographic technique used for the detection of breast lesions. The analysis of the digital image normally requires a previous application of filters as a preprocessing step to reduce the noise level of the image, while preserving important details to carry out a suitable diagnostic. In the literature, there are a large amount of denoising techniques applied to different medical images. In this work we have studied the performance of a diffusive filter with a stopping condition based on the statistical concept of negentropy, applied to denoise mammographic images. The negentropy has been succesfully prove with other denoising methods as independent component analysis by the authors in [1]. We have evaluated the final image quality obtained, measuring a root mean squared error between the noise-free initial image and the final restored image and compared the results obtained by this diffusive filter with those obtained by an adaptative non-linear Wiener filter
Political legitimacy in international border governance institutions

In this article, I address the question: what kind of normative principles should regulate the governance processes through which migration across international borders is managed? I begin by contrasting two distinct categories of normative controversy relating to this question. The first is a familiar set of moral controversies about justice within border governance, concerning what I call the ethics of exclusion. The second is a more theoretically neglected set of normative controversies about how institutional capacity for well functioning border governance can best be achieved, concerning what I call the constitution of control of international borders. I argue that progress can be made in resolving controversies of the latter kind by applying a new normative theory of political legitimacy, distinct from the moral theories of justice routinely applied to ethics of exclusion controversies. On the ‘collective agency’ model of political legitimacy that I propose here, principles of political legitimacy have the regulatory role of combating complex collective action problems that may otherwise impede an institution’s collectively valuable functions. Through applying this theory, I sketch some provisional prescriptions for the design of international border governance institutions that may follow from the demand for strengthening their political legitimacy.
H 2 Guaranteed Cost Computation of Discretized Uncertain Continuous-time Systems ∗

This paper proposes a new discretization technique with constant sampling time for time-invariant systems with uncertain parameters belonging to a polytopic domain. The aim is to provide an equivalent discrete-time representation of the continuous-time system whose H2 guaranteed cost is an upper bound for the H2 worst case norm of the original system. The resulting discrete-time model is described in terms of homogeneous polynomial matrices obtained by Taylor series expansion of degree l. The discretization residual error, associated to the chosen approximation degree, is represented by additive norm-bounded uncertain terms. As a second contribution, new linear matrix inequality (LMI) relaxations for the computation of H2 guaranteed costs for discrete-time systems with polynomial dependence on the uncertain parameter and additive norm-bounded uncertainties are proposed. A numerical experiment shows that the H2 costs of the discretized system become tighter to the continuous-time ones as the order in the Taylor series expansion, the degrees in the Lyapunov function and the Pólya’s relaxation level increase.
Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies

Insights into genetic origin of diseases and related traits could substantially impact strategies for improving human health. The results of genome-wide association studies (GWAS) are often positioned as discoveries of unconditional risk alleles of complex health traits. We re-analyzed the associations of single nucleotide polymorphisms (SNPs) associated with total cholesterol (TC) in a large-scale GWAS meta-analysis. We focused on three generations of genotyped participants of the Framingham Heart Study (FHS). We show that the effects of all ten directly-genotyped SNPs were clustered in different FHS generations and/or birth cohorts in a sex-specific or sex-unspecific manner. The sample size and procedure-therapeutic issues play, at most, a minor role in this clustering. An important result was clustering of significant associations with the strongest effects in the youngest, or 3rd Generation, cohort. These results imply that an assumption of unconditional connections of these SNPs with TC is generally implausible and that a demographic perspective can substantially improve GWAS efficiency. The analyses of genetic effects in age-matched samples suggest a role of environmental and age-related mechanisms in the associations of different SNPs with TC. Analysis of the literature supports systemic roles for genes for these SNPs beyond those related to lipid metabolism. Our analyses reveal strong antagonistic effects of rs2479409 (the PCSK9 gene) that cautions strategies aimed at targeting this gene in the next generation of lipid drugs. Our results suggest that standard GWAS strategies need to be advanced in order to appropriately address the problem of genetic susceptibility to complex traits that is imperative for translation to health care.