Miracle-dz/UniFAR-FTUs huggingface dataset:
Outcomes of Surgery as Part of the Management of Metastatic Non–Small-Cell Lung Cancer: A Surveillance, Epidemiology and End Results Database Analysis

ABSTRACT The role of local treatment in patients with oligometastatic non–small-cell lung cancer (NSCLC) is a subject of ongoing debate. This study assessed the survival impact of combined surgery to the primary tumor and metastatic disease in the management of metastatic NSCLC. Stage IV NSCLC patients at presentation, diagnosed from 2004 to 2013 were identified from the SEER (Surveillance, Epidemiology, and End Results) database. Propensity-matched analysis was performed considering baseline characteristics (age, gender, race, histology, TN stage, and site of metastases). A total of 144,334 patients were identified. The median age group was 65–70 years, and 1139 patients (0.8% of the patients) have received surgical treatment to both the primary tumor and metastatic disease. Both before and after propensity score matching, cancer-specific and overall survival were better in the surgical therapy group (P < 0.0001 for all). When the analysis was restricted to the subsets of patients with brain only M1 disease or isolated contra lateral nodule, overall survival was improved by combined surgery. However, in multivariate analysis of the overall population (postmatching), combined surgery was not associated with a better overall survival (0.576). Despite the apparently beneficial role of surgery in this study for some patients with metastatic disease, the absence of adequate information about systemic therapy as well as associated comorbidity hinders the generation of definite conclusions. Prospective studies are needed to confirm the role of surgery in the setting of metastatic disease.
Ergodic Capacity Analysis of Free-Space Optical Links With Nonzero Boresight Pointing Errors

A unified capacity analysis of a free-space optical (FSO) link that accounts for nonzero boresight pointing errors and both types of detection techniques (i.e. intensity modulation/direct detection as well as heterodyne detection) is addressed in this work. More specifically, an exact closed-form expression for the moments of the end-to-end signal-to-noise ratio (SNR) of a single link FSO transmission system is presented in terms of well-known elementary functions. Capitalizing on these new moments expressions, we present approximate and simple closed-form results for the ergodic capacity at high and low SNR regimes. All the presented results are verified via computer-based Monte-Carlo simulations.
Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid

Several recent studies have suggested that compounds known as endocrine-disrupting chemicals (EDCs) can promote obesity by serving as ligands for nuclear receptors, including the peroxisome proliferator-activated receptor γ (PPARγ) and the glucocorticoid receptor (GR). Thiazolidinedione insulin sensitizers, which act as ligands for PPARγ, also interact with and regulate the activity of the mitochondrial pyruvate carrier (MPC). We evaluated whether several EDCs might also affect MPC activity. Most of the EDCs evaluated did not acutely affect pyruvate metabolism. However, the putative endocrine disruptors tributyltin (TBT) and tolylfluanid (TF) acutely and markedly suppressed pyruvate metabolism in isolated mitochondria. Using mitochondria isolated from brown adipose tissue in mice with adipocyte-specific deletion of the MPC2 protein, we determined that the effect of TF on pyruvate metabolism required MPC2, whereas TBT did not. We attempted to determine whether the obesogenic effects of TF might involve MPC2 in adipose tissue. However, we were unable to replicate the published effects of TF on weight gain and adipose tissue gene expression in wild-type or fat-specific MPC2 knockout mice. Treatment with TF modestly enhanced adipogenic gene expression in vitro but had no effect on GR activation or phosphorylation in cultured cells. These data suggest that TF may affect mitochondrial pyruvate metabolism via the MPC complex but also call into question whether this compound affects GR activity and is obesogenic in mice.
Promotion, Relative Performance Information, and the Peter Principle

ABSTRACT: I examine the effects of providing workers with relative performance information (RPI) on employers' promotion decisions and the impact of those decisions on worker performance. In my experimental setting, the job after promotion requires higher-level abilities than the current job. I find that workers increase their effort to improve their current job performance after a promotion opportunity is announced because they expect this to increase their chances of promotion, even though the new task requires higher-level abilities. Moreover, because employers anticipate that workers who have RPI will react negatively if they see that the best current job performer is not promoted, employers promote the best current job performer, rather than the worker best suited for the next job, more often when workers have RPI than when they do not. Consistent with the Peter Principle, I find that when workers have RPI, the promoted worker's performance is lower after promotion because the promoted worker lacks t.
High Order Compact Splitting Multisymplectic Schemes for 1D Gross-Pitaevskii Equation

We construct two high order compact schemes for 1D Gross-Pitaevskii (GP) equation. These schemes possess properties of multi-symplectic integrators, splitting method and high order compact method. It improves greatly computational efficiency of multisymplectic integrators. Firstly, 1D GP equation is reformulated into multisymplectic formulation. Then, it is split into a linear multisymplectic Hamiltonian and a nonlinear Hamiltonian system. The nonlinear sub-problem can be solved exactly based on new pointwise mass conservation law. The linear problem is discretized by high order compact multi-symplectic integrator. With different composition of the two sub-problems, we obtain two numerical schemes. These schemes have characters of multisymplectic integrators, splitting method and high order compact schemes, and they are mass-preserving as well. Numerical results are reported to illustrate performance of our methods.
Co‐ordination of the expression of the protein tyrosine kinase p56lck with the pre‐T cell receptor during thymocyte development

The protein tyrosine kinase p56lck is essential for the regulation of early thymocyte development by transducing pre‐T cell receptor (pre‐TCR) mediated‐signals. Here we have investigated the developmental timing of expression of p56lck in the thymus. We show that p56lck transcripts are detectable in each CD4–CD8– double‐negative (DN) thymocyte subset defined by CD25 and CD44. The steady‐state level of p56lck mRNA with these four DN subsets is similar, varying by less than 2‐fold. However, p56lck protein levels are undetectable in DN subsets 1 and 2, but are at least 20‐fold up‐regulated between DN subsets 2 and 3. Analysis of independent transgenic mouse lines in which the proximal p56lck promoter was used to drive expression of a green fluorescent protein (GFP) reporter gene revealed a lack of correlation between GFP mRNA expression and transgene copy number and variable expression of GFP protein in different lines. Taken together these results show that the expression of the p56lck gene is developmentally regulated at the post‐transcriptional level at the precise developmental stage at which its upstream receptor complex, the pre‐TCR, is expressed. These results also have implications for the interpretation of the phenotype of transgenic mice which utilize the p56lck proximal promoter.
Failure Mode and Effects Analysis Considering Consensus and Preferences Interdependence

Failure mode and effects analysis is an effective and powerful risk evaluation technique in the field of risk management, and it has been extensively used in various industries for identifying and decreasing known and potential failure modes in systems, processes, products, and services. Traditionally, a risk priority number is applied to capture the ranking order of failure modes in failure mode and effects analysis. However, this method has several drawbacks and deficiencies, which need to be improved for enhancing its application capability. For instance, this method ignores the consensus-reaching process and the correlations among the experts’ preferences. Therefore, the aim of this study was to present a new risk priority method to determine the risk priority of failure modes under an interval-valued Pythagorean fuzzy environment, which combines the extended Geometric Bonferroni mean operator, a consensus-reaching process, and an improved Multi-Attributive Border Approximation area Comparison approach. Finally, a case study concerning product development is described to demonstrate the feasibility and effectiveness of the proposed method. The results show that the risk priority of failure modes obtained by the proposed method is more reasonable in practical application compared with other failure mode and effects analysis methods.
Storage stability of aerobically packaged chicken snacks at ambient temperature (30±2°C).

Chicken snacks were prepared by utilizing spent hen meat (50%), sodium caseinate and rice flour, spice mix, condiments, common salt, phosphate and baking powder. The control snacks were prepared in a similar manner except that spent hen meat was substituted by equal quantity of rice flour. Chicken snack and control were packaged aerobically in laminated (polyethylene/aluminium foil) pouches (size 25X20 cm), stored at 30±2C and analysed for physicochemical, microbiological and sensory characteristics at a regular interval of 0, 6, 12, 18, 24 and 30 days. Both chicken snacks and control indicated highly significant (P<0.01) effect of treatment on contents of fat, protein, ash, thiobarbituric acid (TBA) value, total plate count (TPC), yeast and mould counts (YMC), colour and appearance, flavour, texture, crispness, after taste and overall palatability. Days of storage revealed noticeable effect on shear force value, TPC, enterobacteriacae count (EC), colour and appearance, flavour and crispness of the products. Moreover, aftertaste and overall acceptability of the product were significantly (P<0.05) influenced by days of storage. During storage, not much change in the contents of different constituents, microbiological parameters and sensory profile was noticed up to 30 days.
Matching Protein Interfaces for Improved Medium-Chain Fatty Acid Production.

Medium-chain fatty acids (MCFAs) are key intermediates in the synthesis of medium-chain chemicals including α-olefins and dicarboxylic acids. In bacteria, microbial production of MCFAs is limited by the activity and product profile of fatty acyl-ACP thioesterases. Here, we engineer a heterologous bacterial medium-chain fatty acyl-ACP thioesterase for improved MCFA production in Escherichia coli. Electrostatically matching the interface between the heterologous medium-chain Acinetobacter baylyi fatty acyl-ACP thioesterase (AbTE) and the endogenous E. coli fatty acid ACP ( E. coli AcpP) by replacing small nonpolar amino acids on the AbTE surface for positively charged ones increased secreted MCFA titers more than 3-fold. Nuclear magnetic resonance titration of E. coli 15N-octanoyl-AcpP with a single AbTE point mutant and the best double mutant showed a progressive and significant increase in the number of interactions when compared to AbTE wildtype. The best AbTE mutant produced 131 mg/L of MCFAs, with MCFAs being 80% of all secreted fatty acid chain lengths after 72 h. To enable the future screening of larger numbers of AbTE variants to further improve MCFA titers, we show that a previously developed G-protein coupled receptor (GPCR)-based MCFA sensor differentially detects MCFAs secreted by E. coli expressing different AbTE variants. This work demonstrates that engineering the interface of heterologous enzymes to better couple with endogenous host proteins is a useful strategy to increase the titers of microbially produced chemicals. Further, this work shows that GPCR-based sensors are producer microbe agnostic and can detect chemicals directly in the producer microbe supernatant, setting the stage for the sensor-guided engineering of MCFA producing microbes.
Importance of Reactive Agility and Change of Direction Speed in Differentiating Performance Levels in Junior Soccer Players: Reliability and Validity of Newly Developed Soccer-Specific Tests

Agility is a significant determinant of success in soccer; however, studies have rarely presented and evaluated soccer-specific tests of reactive agility (S_RAG) and non-reactive agility (change of direction speed – S_CODS) or their applicability in this sport. The aim of this study was to define the reliability and validity of newly developed tests of the S_RAG and S_CODS to discriminate between the performance levels of junior soccer players. The study consisted of 20 players who were involved at the highest national competitive rank (all males; age: 17.0 ± 0.9 years), divided into three playing positions (defenders, midfielders, and forwards) and two performance levels (U17 and U19). Variables included body mass (BM), body height, body fat percentage, 20-m sprint, squat jump, countermovement jump, reactive-strength-index, unilateral jump, 1RM-back-squat, S_CODS, and three protocols of S_RAG. The reliabilities of the S_RAG and S_CODS were appropriate to high (ICC: 0.70 to 0.92), with the strongest reliability evidenced for the S_CODS. The S_CODS and S_RAG shared 25–40% of the common variance. Playing positions significantly differed in BM (large effect-size differences [ES]; midfielders were lightest) and 1RM-back-squat (large ES; lowest results in midfielders). The performance levels significantly differed in age and experience in soccer; U19 achieved better results in the S_CODS (t-test: 3.61, p < 0.05, large ES) and two S_RAG protocols (t-test: 2.14 and 2.41, p < 0.05, moderate ES). Newly developed tests of soccer-specific agility are applicable to differentiate U17 and U19 players. Coaches who work with young soccer athletes should be informed that the development of soccer-specific CODS and RAG in this age is mostly dependent on training of the specific motor proficiency.
Designing a personal informatics system for users without experience in self-tracking: a case study

ABSTRACT Thanks to the advancements in ubiquitous and wearable technologies, Personal Informatics (PI) systems can now reach a larger audience of users. However, it is not still clear whether this kind of tool can fit the needs of their daily lives. Our research aims at identifying specific barriers that may prevent the widespread adoption of PI and finding solutions to overcome them. We requested users without competence in self-tracking to use different PI instruments during their daily practices, identifying five user requirements by which to design novel PI tools. On such requirements, we developed a new system that can stimulate the use of these technologies, by enhancing the perceived benefits of collecting personal data. Then, we explored how naïve and experienced users differently explore their personal data in our system through a user trial. Results showed that the system was successful at helping individuals manage and interpret their own data, validated the usefulness of the requirements found and inspired three further design opportunities that could orient the design of future PI systems.
Vitamin D Deficiency Is Not Associated With Growth or the Incidence of Common Morbidities Among Tanzanian Infants

Objective: The objective of this study was to examine risk factors for vitamin D deficiency and determine the association of vitamin D status with child growth and incidence of common morbidities among Tanzanian infants. Methods: A prospective cohort of 581 Tanzanian infants born to human immunodeficiency virus (HIV)-uninfected mothers had serum 25-hydroxyvitamin D assessed at 6 weeks and 6 months of age. Infants were seen at monthly clinic visits for growth monitoring until 18 months of age. Physicians examined infants every 3 months or when an illness was noted to document morbidities. Results: The prevalence of vitamin D deficiency (<20 ng/mL) declined from 76.4% at 6 weeks of age to 21.2% at 6 months. Infants who were exclusively breastfed at 6 weeks of age had 2.05 (95% confidence interval 1.11–3.79; P = 0.02) times the risk of vitamin D deficiency as compared formula-fed infants. After multivariate adjustment, there was no association of vitamin D status at 6 weeks or 6 months with the incidence of stunting, wasting, or underweight. There was also no association of low vitamin D with the incidence of diarrhea, upper respiratory infection, acute lower respiratory tract infection, or malaria. Conclusions: Vitamin D deficiency is common during early infancy, particularly among exclusively breastfed infants; however, these observational data suggest it may not be an important contributor to morbidity and growth among the general population of Tanzanian infants. Future studies of vitamin D among high-risk infants, including those with low birthweight and exposed to HIV, may be warranted.
Mapping the relationships between high-performance work systems, employee resilience and engagement: a study of the banking industry in China

Abstract There is now growing interest in employee resilience in the organizational context and its contribution to organizational performance. However, little is known the extent to which high-performance work systems (HPWS) contributes towards enhancing employee’s resilience as well as their levels of engagement. This study examines the relationships among HPWS, employee resilience and engagement, using a sample of 2040 employees in the Chinese banking industry. Drawing on the job demands-resources model and strategic/high-performance human resource management theory, we develop three hypotheses to test the relationship between HPWS and employee resilience, resilience and employee engagement, and the mediating effect of resilience on the relationship between HPWS and engagement. All hypotheses are supported and suggest that HPWS can be used as a job resource to positively affect resilience and subsequently employee engagement. The key message of the paper is that employee resilience can be viewed as a set of skills and attributes that can be developed through the effective use of HPWS to benefit both individuals and the organization.
Insights in particulate matter‐induced allergic airway inflammation: Focus on the epithelium

Outdoor air pollution is a major environmental health problem throughout the world. In particular, exposure to particulate matter (PM) has been associated with the development and exacerbation of several respiratory diseases, including asthma. Although the adverse health effects of PM have been demonstrated for many years, the underlying mechanisms have not been fully identified. In this review, we focus on the role of the lung epithelium and specifically highlight multiple cytokines in PM‐induced respiratory responses. We describe the available literature on the topic including in vitro studies, findings in humans (ie observations in human cohorts, human controlled exposure and ex vivo studies) and in vivo animal studies. In brief, it has been shown that exposure to PM modulates the airway epithelium and promotes the production of several cytokines, including IL‐1, IL‐6, IL‐8, IL‐25, IL‐33, TNF‐α, TSLP and GM‐CSF. Further, we propose that PM‐induced type 2‐promoting cytokines are important mediators in the acute and aggravating effects of PM on airway inflammation. Targeting these cytokines could therefore be a new approach in the treatment of asthma.
Direct Activation of Angiotensin II Type 2 Receptors Enhances Muscle Microvascular Perfusion, Oxygenation, and Insulin Delivery in Male Rats

Angiotensin II receptors regulate muscle microvascular recruitment and the delivery of nutrients, oxygen, and insulin to muscle. Although angiotensin type 1 receptor antagonism increases muscle microvascular perfusion and insulin action, angiotensin type 2 receptor blockade markedly restricts muscle microvascular blood volume and decreases muscle delivery of insulin. To examine the effects of direct type 2 receptor stimulation using Compound 21 (C21) on microvascular perfusion, insulin delivery and action, and tissue oxygenation in muscle, overnight-fasted adult male rats were infused with C21 systemically. C21 potently increased microvascular blood volume without altering microvascular flow velocity or blood pressure, resulting in a net increase in microvascular blood flow in muscle. This was associated with a substantial increase in muscle interstitial oxygen saturation and insulin delivery into the skeletal and cardiac muscle. These effects were neutralized by coinfusion of the type 2 receptor antagonist or nitric oxide synthase inhibitor. Superimposing C21 infusion on insulin infusion increased insulin-mediated whole body glucose disposal by 50%. C21 significantly relaxed the preconstricted distal saphenous artery ex vivo. We have concluded that direct type 2 receptor stimulation markedly increases muscle microvascular perfusion through nitric oxide biosynthesis and enhances insulin delivery and action in muscle. These findings provide a physiologic mechanistic insight into type 2 receptor modulation of insulin action and suggest that type 2 receptor agonists might have therapeutic potential in the management of diabetes and its associated complications.
A Memory Network Approach for Story-Based Temporal Summarization of 360° Videos

We address the problem of story-based temporal summarization of long 360° videos. We propose a novel memory network model named Past-Future Memory Network (PFMN), in which we first compute the scores of 81 normal field of view (NFOV) region proposals cropped from the input 360° video, and then recover a latent, collective summary using the network with two external memories that store the embeddings of previously selected subshots and future candidate subshots. Our major contributions are twofold. First, our work is the first to address story-based temporal summarization of 360° videos. Second, our model is the first attempt to leverage memory networks for video summarization tasks. For evaluation, we perform three sets of experiments. First, we investigate the view selection capability of our model on the Pano2Vid dataset [42]. Second, we evaluate the temporal summarization with a newly collected 360° video dataset. Finally, we experiment our model's performance in another domain, with image-based storytelling VIST dataset [22]. We verify that our model achieves state-of-the-art performance on all the tasks.
Diabetes‐induced microvascular complications at the level of the spinal cord: a contributing factor in diabetic neuropathic pain

Diabetes is thought to induce neuropathic pain through activation of dorsal horn sensory neurons in the spinal cord. Here we explore the impact of hyperglycaemia on the blood supply supporting the spinal cord and chronic pain development. In streptozotocin‐induced diabetic rats, neuropathic pain is accompanied by a decline in microvascular integrity in the dorsal horn. Hyperglycaemia‐induced degeneration of the endothelium in the dorsal horn was associated with a loss in vascular endothelial growth factor (VEGF)‐A165b expression. VEGF‐A165b treatment prevented diabetic neuropathic pain and degeneration of the endothelium in the spinal cord. Using an endothelial‐specific VEGFR2 knockout transgenic mouse model, the loss of endothelial VEGFR2 signalling led to a decline in vascular integrity in the dorsal horn and the development of hyperalgesia in VEGFR2 knockout mice. This highlights that vascular degeneration in the spinal cord could be a previously unidentified factor in the development of diabetic neuropathic pain.