Miracle-dz/UniFAR-FTUs huggingface dataset:
Increases of the Th1/Th2 cell ratio in severe Hashimoto's disease and in the proportion of Th17 cells in intractable Graves' disease.

BACKGROUND T helper type 1 (Th1), Th2, and Th17 cells produce interferon (IFN)-gamma, interleukin (IL)-4, and IL-17A, respectively. We reported that IFN-gamma and IL-4 gene polymorphisms, which are related to higher IFN-gamma and lower IL-4 production, respectively, are more frequent in patients with severe Hashimoto's disease (HD) than in those mild HD. We now aim to investigate the proportion of peripheral Th1, Th2, and Th17 cells in patients with autoimmune thyroid disease (AITD). METHODS We studied 17 patients with HD who developed hypothyroidism and were treated with l-thyroxine, referred to as severe HD; 17 untreated patients with HD who were euthyroid, referred to as mild HD; 18 euthyroid patients with Graves' disease (GD) who remained positive for anti-thyrotropin receptor antibody (TRAb) despite being treated with anti-thyroid drugs for more than 5 years, referred to as intractable GD; and 17 patients with GD who were euthyroid and negative for TRAb for more than 2 years after cessation of anti-thyroid drugs, referred to as GD in remission; and 10 control subjects without AITD. By the definitions in this study Th1 cells were CD4(+)IFN-gamma(+)IL-4(-)IL-17A(-) cells, Th2 cells were CD4(+)IFN-gamma(-)IL-4(+)IL-17A(-) cells, and CD4(+)IFN-gamma(-)IL-4(-)IL-17A(+) cells were Th17 cells. RESULTS The proportion of peripheral Th1 cells was higher in patients with severe HD than in patients with mild HD (p < 0.05), and the proportion of peripheral Th2 cells was lower in patients with severe HD than in patients with mild HD (p < 0.001). Therefore the Th1/Th2 ratio was higher in severe than in mild HD patients (p < 0.001). The proportion of peripheral Th17 cells in patients with AITD was higher than in control subjects and the proportion of these cells in patients with intractable GD was higher than in patients with GD in remission (p < 0.05). CONCLUSIONS The peripheral Th1/Th2 cell ratio is related to the severity of HD, and the proportion of Th17 cells is related to the intractability of GD. We hypothesize that these patterns of peripheral Th cell subsets may be expressed within the thyroid.
An intrinsic volatility scale relevant to the Earth and Moon and the status of water in the Moon

The notion of a dry Moon has recently been challenged by the discovery of high water contents in lunar apatites and in melt inclusions within olivine crystals from two pyroclastic glasses. The highest and most compelling water contents were found in pyroclastic glasses that are not very common on the lunar surface. To obtain more representative constraints on the volatile content of the lunar interior, we measured the Zn content, a moderately volatile element, of mineral and rock fragments in lunar soils collected during Apollo missions. We here confirm that the Moon is significantly more depleted in Zn than the Earth. Combining Zn with existing K and Rb data on similar rocks allows us to anchor a new volatility scale based on the bond energy of nonsiderophile elements in their condensed phases. Extrapolating the volatility curve to H shows that the bulk of the lunar interior must be dry (≤1 ppm). This contrasts with the water content of the mantle sources of pyroclastic glasses, inferred to contain up to approximately 40 ppm water based on H2O/Ce ratios. These observations are best reconciled if the pyroclastic glasses derive from localized water‐rich heterogeneities in a dominantly dry lunar interior. We argue that, although late addition of 0.015% of a chondritic veneer to the Moon seems required to explain the abundance of platinum group elements (Day et al. 2007), the volatile content of the added material was clearly heterogeneous.
Association between Longitudinally Assessed Dietary Composition and Blood Telomere Length among Young Adult Filipinos

Association between Longitudinally Assessed Dietary Composition and Blood Telomere Length among Young Adult Filipinos Hilary Jeanne Bethancourt Chair of the Supervisory Committee: Mario Kratz Department of Epidemiology Diet and nutrition are known to play a pivotal role in the onset and progression of agingrelated diseases, but it remains unclear how diet and nutrition influence aging processes in general. Telomeres, the nucleotide sequences that protect linear chromosome ends from degradation, are considered a biomarker of aging. Evidence that oxidative stress and inflammation can accelerate telomere attrition suggests that nutritional factors may impact telomere length (TL) and, hence, aging by either contributing to or protecting against oxidative and inflammatory processes. However, previous studies have produced inconsistent results on the relationship between TL and diet or nutritional status. Most studies have been crosssectional and have been conducted among older adult Western populations. This study aimed to explore the association between longitudinally-assessed diet and adiposity measures and TL among a young Filipino population. Specifically, it tested the hypotheses that 1) processed meats, fried or grilled meats, coconut oil, and non-diet soda are each inversely associated with TL; 2) fish and fruit and vegetable consumption are positively associated with TL; 3) body mass index is associated with TL in a curvilinear fashion; and 4) height-adjusted waist circumference is inversely associated with TL. Contrary to all hypotheses, the data provided no evidence of an association between TL and any of the dietary factors of interest or either of the measures of adiposity. These results contrast with some previous studies but align with others. The lack of associations may have
One direction S-rough decision and its decision model

This paper presents one direction S-rough decision and its decision model and characteristics. One direction S-rough decision is the combination of S-rough decision on (R,F)/sub /spl deg//(X/spl deg/) and S-rough decision on (R,F)/spl deg/(X/spl deg/) ; (R,F)/sub /spl deg//(X/spl deg/), (R,F)/spl deg/(X/spl deg/) are common sets with dynamic characteristics; (R,F)/sub /spl deg//(X/spl deg/), (R,F)/spl deg/(X/spl deg/) are the lower approximation and upper approximation of S-sets (singular sets) X/spl deg//spl sub/U respectively.
DETERMINATION DU COEFFICIENT DE TRANSMISSION DES UNITES DE PRECONTRAINTE

LA METHODE DECRITE EST APPLICABLE A TOUTES LES UNITES DE PRECONTRAINTE UTILISEES DANS LES STRUCTURES PRECONTRAINTES PAR POST-TENSION. ELLE CONSISTE A ENREGISTRER PENDANT TOUTE LA DUREE DE LA MISE EN TENSION LES PRESSIONS DANS LES VERINS ACTIF ET PASSIF (TECHNIQUE DES VERINS DITS "EN OPPOSITION". LE COEFFICIENT DE TRANSMISSION EST EGAL A LA PENTE M DE LA DROITE P DESIGNANT LA PRESSION DANS LE VERIN PASSIF = F (PA), PA ETANT LA PRESSION DANS LE VERIN ACTIF, CORRIGE DE L'EFFET DES PERTES AUX VERINS.
Identification and antimicrobial resistance of members from the Enterobacteriaceae family isolated from canaries ( Serinus canaria ) 1

Horn R.V. , Cardoso W.M. , Lopes E.S. , Teixeira R.S. C. , Albuquerque A.H. , Rochae-Silva R.C. , Machado D.N. & Bezerra W.G. A. 2015. Identification and antimicrobial resistance of members from the Enterobacteriaceae family isolated from canaries (Serinus canaria). Pesquisa Veterinária Brasileira 35(6):552-556. Laboratório de Estudos Ornitológicos, Faculdade de Veterinária, Universidade Estadual do Ceará, Av. Paranjana 1700, Fortaleza, CE 60740-000, Brazil. E-mail: rubenhorn@hotmail.com The Enterobacteriaceae family contains potentially zoonotic bacteria, and their presence in canaries is often reported, though the current status of these in bird flocks is unknown. Therefore, this study aimed to identify the most common genera of enterobacteria from canaries (Serinus canaria) and their antimicrobial resistance profiles. From February to June of 2013, a total of 387 cloacal swab samples from eight domiciliary breeding locations of Fortaleza city, Brazil, were collected and 58 necropsies were performed in canaries, which belonged to the Laboratory of Ornithological Studies. The samples were submitted to microbiological procedure using buffered peptone water and MacConkey agar. Colonies were selected according to their morphological characteristics on selective agar and submitted for biochemical identification and antimicrobial susceptibility. A total of 61 isolates were obtained, of which 42 were from cloacal swabs and 19 from necropsies. The most isolated bacteria was Escherichia coli with twenty five strains, followed by fourteen Klebsiella spp. , twelve Enterobacter spp. , seven Pantoea agglomerans, two Serratia spp. and one Proteus mirabilis. The antimicrobial to which the strains presented most resistance was sulfonamides with 55.7%, followed by ampicillin with 54.1% and tetracycline with 39.3%. The total of multidrug-resistant bacteria (MDR) was 34 (55.7%). In conclusion, canaries harbor members of the Enterobacteriaceae family and common strains present a high antimicrobial resistance rate, with a high frequency of MDR bacteria.
I Think I Am Doing Great but I Feel Pretty Bad About It

Four experiments were conducted to examine the effect of responding to self-report items framed with either a cognitive verb (think) or an affective verb (feel). Participants’ open-ended self-descriptions were significantly more negative when they responded to a feel prompt than when they responded to a think prompt (Experiments 1 and 2). This effect persisted and influenced scores on a subsequent measure of self-esteem (Experiment 2). Substituting the verb think for feel in the Rosenberg self-esteem scale resulted in significantly higher reported self-esteem for female participants but not for male participants (Experiments 3 and 4). The research contributes to the literature demonstrating the subtle effects of word choice on responses to self-report items.
Toddlers learn words in a foreign language: the role of native vocabulary knowledge

ABSTRACT The current study examined monolingual English-speaking toddlers' (N=50) ability to learn word–referent links from native speakers of Dutch versus English, and second, whether children generalized or sequestered their extensions when terms were tested by a subsequent speaker of English. Overall, children performed better in the English than in the Dutch condition; however, children with high native vocabularies successfully selected the target object for terms trained in fluent Dutch. Furthermore, children with higher vocabularies did not indicate their comprehension of Dutch terms when subsequently tested by an English speaker whereas children with low vocabulary scores responded at chance levels to both the original Dutch speaker and the second English speaker. These findings demonstrate that monolingual toddlers with proficiency in their native language are capable of learning words outside of their conventional system and may be sensitive to the boundaries that exist between language systems.
On the modeling of blackouts in power networks

We describe a model of power networks which may be useful for studying power blackouts. The model is a combination of the admittance model of the network and the probabilistic model of faults of its components. To compute the probability of a power outage possible failure events are considered and in each case the possibility of a cascading failure is studied. Graph representation of the network is used to detect connected components in the network, and then network equations are solved separately in each component. We show how to use this model to compute the probability of a power blackout in power networks and how this model can be used to develop suggestions for improving power network designs. The IEEE 188 bus is considered to show the usefulness of this approach.
The Endogenous Melatonin Profile as a Marker for Circadian Phase Position

Several circadian rhythms have been used to assess the phase of the endogenous circadian pacemaker (ECP). However, when more than one marker rhythm is measured, results do not always agree. Questions then inevitably arise. Are there multiple oscillators? Are some markers more reliable than others? Masking is a problem for all marker rhythms. Masking of melatonin is minimized by sampling under dim light. The dim-light melatonin onset (DLMO) is particularly convenient since it can usually be obtained before sleep. However, assessing the DLMO in low melatonin producers may be problematic, particularly with the commonly used operationally defined threshold of 10 pg/ml. This study evaluates various circadian phase markers provided by the plasma melatonin profile in 14 individuals, several of whom are low melatonin producers. The amount (amplitude) of melatonin production appears to influence the phase of many points on the melatonin profile. Accordingly, when low producers are in a data set, we now prefer a lower DLMO threshold than the one previously recommended (10 pg/ml). Indeed, there are some low producers who never exceed this threshold at any time. Radioimmunoassays are now available that have the requisite sensitivity and specificity to support the use of a lower threshold. Nevertheless, the dim-light melatonin offset (DLMOff), even when operationally defined at thresholds less than 10 pg/ml, appears to be confounded by amplitude in this study; in such cases, it may be preferable to use the melatonin synthesis offset (SynOff) because it is not confounded by amplitude and because, theoretically, it is temporally closer to the endogenous mechanism signaling the offset of production. The question of whether the termination mechanism of melatonin synthesis is related to an interval timer or to a second oscillator loosely coupled to the onset oscillator is probably best answered using the SynOff rather than the DLMOff. It is hoped that these findings will make a useful contribution to the debate on the best ways to use points on the melatonin profile to assess circadian phase position in humans.
Anti‐PSMA immunotoxin as novel treatment for prostate cancer? High and specific antitumor activity on human prostate xenograft tumors in SCID mice

Expression of the prostate specific membrane antigen (PSMA) is highly restricted to prostate epithelial cells. Therefore, toxin‐based immunotherapy against this antigen may represent an alternative therapeutic option for prostate cancer. For these purposes, the effects of the recombinant anti‐PSMA immunotoxin A5‐PE40 on prostate tumor growth were investigated in vitro and in vivo.
Targeted Inactivation of the mecB Gene, Encoding Cystathionine-γ-Lyase, Shows that the Reverse Transsulfuration Pathway Is Required for High-Level Cephalosporin Biosynthesis inAcremonium chrysogenum C10 but Not for Methionine Induction of the Cephalosporin Genes

ABSTRACT Targeted gene disruption efficiency in Acremonium chrysogenum was increased 10-fold by applying the double-marker enrichment technique to this filamentous fungus. Disruption of themecB gene by the double-marker technique was achieved in 5% of the transformants screened. Mutants T6 and T24, obtained by gene replacement, showed an inactive mecB gene by Southern blot analysis and no cystathionine-γ-lyase activity. These mutants exhibited lower cephalosporin production than that of the control strain, A. chrysogenum C10, in MDFA medium supplemented with methionine. However, there was no difference in cephalosporin production between parental strain A. chrysogenum C10 and the mutants T6 and T24 in Shen's defined fermentation medium (MDFA) without methionine. These results indicate that the supply of cysteine through the transsulfuration pathway is required for high-level cephalosporin biosynthesis but not for low-level production of this antibiotic in methionine-unsupplemented medium. Therefore, cysteine for cephalosporin biosynthesis in A. chrysogenum derives from the autotrophic (SH2) and the reverse transsulfuration pathways. Levels of methionine induction of the cephalosporin biosynthesis gene pcbC were identical in the parental strain and the mecB mutants, indicating that the induction effect is not mediated by cystathionine-γ-lyase.
TNFα Inhibitors May Improve Asthma Symptoms: A Case Series of 12 Patients With Rheumatoid Arthritis and Asthma

Asthma is a chronic inflammatory disease that constitutes one of the leading causes of chronic obstructive pulmonary disease(1). Most patients with moderate or severe disease are treated with inhaled corticosteroids, but many patients have refractory disease(2). Treatment options for these refractory patients are limited; there are emerging data on the effectiveness of tumor necrosis factor alpha (TNF)α inhibitors(3–5), but there are no long-term studies. In this report, we studied a large prospective RA cohort, the Brigham Rheumatoid Arthritis Sequential Study (BRASS), to identify a case series of patients with both RA and asthma, who were treated with TNFα inhibitors. We aimed to determine whether asthma symptoms correlated with TNFα inhibitor therapy.
Research on the Novel Grid-Connected System of Distributed Generation

The grid-connected operating mode of distributed generation (DG) is now the trend of the development of DG. In this paper, the topology and mathematical model of a grid-connected system of DG are studied deeply, instantaneous reactive power theory and hysteretic comparison control strategy have been chosen, and a grid-connected system is got which can send the active power to the grid, compensate harmonic and absorb the reactive power that the local loads generated. Then the simulation models of main circuit and control circuit of the grid-connected system of DG have been established using MATLAB, and the two different filter modes of the grid-connected system are analyzed and simulated which verified the grid-connected system reliable and valid.
Finite-time stabilisation for high-order nonlinear systems with low-order and high-order nonlinearities

This paper considers the finite-time stabilisation for a class of high-order nonlinear systems with both low-order and high-order nonlinearities. Based on the finite-time Lyapunov stability theorem together with the methods of dynamic gain control and adding one power integrator, a state feedback controller with gains being tuned online by two dynamic equations is proposed to guarantee the global finite-time stabilisation of the closed-loop system.
Six/one router: a scalable and backwards compatible solution for provider-independent addressing

The scalability of the Internet routing system suffers from an increasing demand for provider-independent, non-aggregatable IP addresses in networks at the Internet edge. New routing architectures have been proposed that mitigate this problem through indirection between provider-independent addresses at the edge and aggregatable, provider-allocated addresses in the core of the Internet. A major challenge in these architectures is backwards compatibility. Address indirection requires support at the sender and the receiver, so without appropriate backwards compatibility support, it defeats communications between the upgraded and the legacy Internet. This paper proposes an address-indirection-based solution that is backwards compatible. The solution is shown to offer the benefits of provider-independent addressing in a scalable and backwards compatible manner, and to provide the incentives necessary to foster its early deployment.
Adsorption of Se, Na, and O on the Mo(110) surface: Modeling atomic mechanisms at the back contact of thin film chalcopyrite solar cells

The deposition of the chalcopyrite light absorbers onto the back contact of thin films solar cells involves the adsorption of Se on Mo surfaces, to form an intermediate MoSe2 layer. Together with Se and the other elements composing the absorber, also impurities like oxygen and sodium are present in common processing technologies. In order to promote the understanding of atomic mechanisms and basic thermodynamic parameters related to deposition, we predict the adsorption energies and most stable adsorption sites of Se, O and Na on the Mo(110) surface using first principles calculations, based on density functional theory. We discuss implications for kinetics on the surface.
Inhibition of protein glycation by procyanidin‐B2 enriched fraction of cinnamon: Delay of diabetic cataract in rats

Accumulation of advanced glycation endproducts (AGE) from nonenzymatic glycation of proteins has been implicated in several diabetic complications including diabetic cataract. Previously, we have reported that extracts of dietary agents such as cinnamon have the potential to inhibit AGE formation. In this study, we have shown procyanidin‐B2 as the active component of cinnamon that is involved in AGE inhibition using bioassay‐guided fractionation of eye lens proteins under in vitro conditions. The data indicate that procyanidin‐B2 enriched fraction scavenges dicarbonyls. Further, procyanidin‐B2 fraction of cinnamon inhibited the formation of glycosylated hemoglobin in human blood under ex vivo conditions. We have also demonstrated the physiological significance of procyanidin‐B2 fraction in terms of delay of diabetic cataract through inhibition of AGE in diabetic rats. These findings establish the antiglycating potential of procyanidin‐B2 fraction of cinnamon which suggests a scope for controlling AGE‐mediated diabetic complications by food sources that are rich in proanthocyanidins like procyanidin‐B2. © 2013 IUBMB Life, 65(11):941–950, 2013
Distributive Quasi-Ballistic Drift Diffusion Model Including Effects of Stress and High Driving Field

This paper presents a simulation study using a novel distributive quasi-ballistic drift diffusion (DD) TCAD model applied to low mobility unstressed and high mobility stressed scaled pMOS devices. The model is implemented in a DD simulator and used to study the gate length dependence of current drives. The new model captures the physically correct potential distribution and gives the correct drive current limit in ballistic devices for both linear current response and current saturation source-drain bias conditions. The diffusive and ballistic transport is connected using a ballistic probability, which relates to the fundamental time scale in the problem-the mean energy relaxation time. The model captures the ballistic velocity degradation from the diffusive limit at linear source-drain biases. It is shown that the DD simulation with the distributive quasi-ballistic model describes the stress ballistic drive gains at high driving field, which are missed by the existing ballistic models.
1-(4-Nitrobenzoyl)-3-(4-nitrophenyl)thiourea acetone hemisolvate

In the title compound, C14H10N4O5S·0.5C3H6O, the nitrobenzoyl and nitrophenyl groups have trans and cis configurations, respectively, with respect to the thiourea S atom. The molecular conformation is stabilized by intramolecular N—H⋯O and C—H⋯S hydrogen bonds. The acetone solvent molecule possesses a crystallographically imposed twofold axis. In the crystal packing, thiourea molecules are linked by intermolecular C—H⋯O hydrogen-bond interactions to form chains running parallel to the c axis. The chains are further bridged via N—H⋯O and C—H⋯O hydrogen bonds involving the acetone molecules.
Gene for Heat-Inducible Lysyl-tRNA Synthetase (lysU) Maps near cadA in Escherichia coli

A hybrid ColE1 plasmid from the Clarke-Carbon colony bank with a 7-kilobase insertion was found to encode the inducible lysyl-tRNA synthetase along with the catabolic enzyme lysine decarboxylase. The gene for the inducible synthetase, lysU, must lie within 0.3 min of the lysine decarboxylase gene, cadA, at 92 min on the Escherichia coli genetic map.
Adenomatoid odontogenic tumor: A unique report with histological diversity

Odontogenic tumors are a group of heterogeneous lesions, features of which have been catalogued for several decades. Adenomatoid odontogenic tumor (AOT) is a relatively rare and distinct odontogenic tumor that is exclusively odontogenic epithelium in origin. Although considerable number of reports is available with regard to the clinical and histological spectrum of AOT, very few have highlighted its varied histological presentations. Therefore, this article focuses on the assorted histoarchitectural patterns of AOT.