Miracle-dz/UniFAR-FTUs huggingface dataset:
The Multi-Domain Frame Packing Problem for CAN-FD

The Controller Area Network with Flexible Data-Rate (CAN-FD) is a new communication protocol to meet the bandwidth requirements for the constantly growing volume of data exchanged in modern vehicles. The problem of frame packing for CAN-FD, as studied in the literature, assumes a single sub-system where one CAN-FD bus serves as the communication medium among several Electronic Control Units (ECUs). Modern automotive electronic systems, on the other hand, consist of several sub-systems, each facilitating a certain functional domain such as powertrain, chassis and suspension. A substantial fraction of all signals is exchanged across sub-systems. In this work, we study the frame packing problem for CAN-FD with multiple sub-systems, and propose a two-stage optimization framework. In the first stage, we pack the signals into frames with the objective of minimizing the bandwidth utilization. In the second stage, we extend Audsley's algorithm to assign priorities/identifiers to the frames. In case the resulting solution is not schedulable, our framework provides a potential repacking method. We propose two solution approaches: (a) an Integer Linear Programming (ILP) formulation that provides an optimal solution but is computationally expensive for industrial-size problems; and (b) a greedy heuristic that scales well and provides solutions that are comparable to optimal solutions. Experimental results show the efficiency of our optimization framework in achieving feasible solutions with low bandwidth utilization. The results also show a significant improvement over the case when there is no cross-domain consideration (as in prior work).
The Meaningful Place: Transforming Taman Sari Banda Aceh as City Park

City Park is a public space which should be utilized optimally by the community. One of the city parks intersecting with the center of facilities and infrastructure of Banda Aceh city is Taman Sari. The condition of the urban park in Banda Aceh city is not comfortable enough. Therefore, people tend not to use public space optimally, in this case, as a place for interacting and holding the certain events. This research was intended to conduct a systematic observation on the utilization of Taman Sari (the city park) to maximize its function as public area and manage the efforts for the improvement of the area related to transformation of recreational area as the local playground into more meaningful, purposeful and useful site in term of social, economic, and environment sectors. The data obtained through field surveys, interviews and the study of literature as well as providing documentation about the activities of the community by analyzing the qualitative descriptive methods. The result showed that the city park which was also as the representative public open area in Banda Aceh did not provide public facilities sufficiently. Therefore, the existence of the city park would not only act as a playground but it could be more functional and beneficial in accordance with social and recreational activities, community creative art and entertainment, entrepreneurial activities as well as environmental conservation. The Availability of public facilities would provide more attracting values to invite public to utilize the area as the center for many activities.
Incidence and Mechanism of Ciprofloxacin Resistance in Campylobacter spp. Isolated from Commercial Poultry Flocks in the United Kingdom before, during, and after Fluoroquinolone Treatment

ABSTRACT Five commercial broiler flocks were treated with a fluoroquinolone for a clinically relevant infection. Fresh feces from individual chickens and environmental samples were cultured for campylobacters before, during, and weekly posttreatment until slaughter. Both Campylobacter jejuni and C. coli were isolated during all treatment phases. An increased proportion of quinolone-resistant strains was seen during treatment, and these strains persisted posttreatment. One quinolone-resistant isolate of each species, each serotype, and each phage type from each sample at all treatment phases was examined for its phenotype and mechanism of resistance. Two resistant phenotypes were isolated: Nalr Cipr and Nalr Cips. The majority (269 of 290) of fluoroquinolone-resistant isolates, whether they were C. jejuni or C. coli, had a mutation in gyrA that resulted in the substitution Thr-86→Ile. The other gyrA mutations detected were Thr-86→Ala (n = 17) and Asp-90→Asn (n = 10). The genotypic variation, based on the silent mutations in gyrA identified by the denaturing high-performance liquid chromatography pattern and DNA sequencing, was used to supplement typing data and provided evidence for both the spread of preexisting resistant strains and the selection of spontaneous resistant mutants in treated flocks. Multidrug resistance was significantly (P < 0.01) associated with resistance to ciprofloxacin. Twenty-five percent (73 of 290) of ciprofloxacin-resistant isolates but only 13% (24 of 179) of susceptible isolates were resistant to three or more unrelated antimicrobial agents. In conclusion, quinolone-resistant campylobacters were isolated from commercial chicken flocks in high numbers following therapy with a veterinary fluoroquinolone. Most ciprofloxacin-resistant isolates had the GyrA substitution Thr-86→Ile. Resistant isolates were isolated from the feces of some flocks up to the point of slaughter, which may have consequences for public health.
Optimisation et fiabilité des calculs éléments finis en élastoplasticité

La methode des elements finis permet d'obtenir des solutions approchees en elastoplasticite. L'objectif de ce travail est d'apporter une solution aux trois problemes suivants, dans le cas classique de l'approche deplacements : i) apprecier la qualite des solutions obtenues; 2. Assurer la fiabilite des solutions, c'est a dire le respect d'une qualite minimale; 3. A qualite egale, miniser le cout associe aux calculs, donc les optimiser. La methode proposee est nouvelle. Elle s'appuie principalement sur la notion d'erreur en relation de comportement associee a un couple (u, sigma) ou u est un champ de deplacement cinematiquement admissible et sigma un champ de contrainte admissible. C'est une methode generale qui etend aux analyses elastoplastiques la methode proposee par p. Ladeveze. Deux types de definitions de l'erreur en relation de comportement sont donnees au chapitre 2. Elles s'appliquent a une large classe de materiaux comprenant les materiaux standart. Nous associons a la solution elements finis deplacements un couple (u, sigma) ou u est le deplacement donne par cette solution et ou sigma est un champ de contrainte statiquement admissible. Ce champ statiquement admissible est obtenu directement a partir du champ de contrainte associe a la solution deplacement par des calculs locaux. Ceci nous permet de caracteriser la qualite de la solution elements finis par l'erreur en relation de comportement associee au couple u, sigma. La methode de construction du champ statiquement admissible presente au chapitre 5. Elle s'effectue en deux etapes : calcul de densites sur les phases des elements puis, element par element, determination du champ (prolongement optimal) a partir de ces densites. La qualite de la solution elements finis etant ainsi definie, nous proposons au chapitre 4 deux procedures permettant d'assurer la fiabilite de cette solution, tout en minimisant le temps de calcul par la construction de maillages optimaux. Cette construction est realisee en utilisant les resultats d'un premier calcul effectue sur un maillage "pere". La distribution de l'erreur dans les elements de ce maillage permet, sur des bases heulistiques, la construction d'un nouveau maillage optimal respectant une qualite imposee a l'avance. Des exemples illustrent ces procedures. Ils ont ete realises en utilisant le logiciel optifia mis au point au cours de ce travail et presente dans ces grandes lignes au chapitre 6
Molecular prenatal diagnosis in a case of an X‐linked dominant chondrodysplasia punctata

X‐linked dominant chondrodysplasia punctata, (CDPX2—MIM302960) also known as Conradi–Hünermann–Happle syndrome, is a rare form of skeletal dysplasia that affects the skeleton, skin, hair, and eyes. The disorder is caused by mutations within the emopamil binding protein (Ebp) that functions as a delta(8), delta(7) sterol isomerase in the cholesterol biosynthesis pathway. To date, over 40 separate mutations have been reported in the Ebp gene, EBP, with no obvious correlation between the molecular defects and the severity of the clinical phenotype. We have studied a 30‐year‐old woman who presented in adulthood with skin, hair, and mild skeletal defects but no ocular abnormalities and have identified a heterozygous missense mutation within the third transmembrane domain of the protein. In addition, we have performed molecular prenatal testing on her unborn fetus. The results demonstrate inter‐familial variability for missense mutations within the emopamil binding protein and add to the molecular data for CDPX2. Copyright © 2003 John Wiley & Sons, Ltd.
Style of religious texts in 20th century

In this study, we present the results of the investigation of diachronic stylistic changes in 20th century religious texts in two major English language varieties – British and American. We examined a total of 146 stylistic features, divided into three main feature sets: (average sentence length, Automated readability index, lexical density and lexical richness), part-of-speech frequencies and stop-words frequencies. All features were extracted from the raw text version of the corpora, using the state-of-the-art NLP tools and techniques. The results reported significant changes of various stylistic features belonging to all three aforementioned groups in the case of British English (1961–1991) and various features from the second and third group in the case of American English (1961–1992). The comparison of diachronic changes between British and American English pointed out very different trends of stylistic changes in these two language varieties. Finally, the applied machine learning classification algorithms indicated the stop-words frequencies as the most important stylistic features for diachronic classification of religious texts in British English and made no preferences between the second and third group of features in diachronic classification in American English.
Pure Immanence: Essays on A Life

The essays in this book present a complex theme at the heart of the philosophy of Gilles Deleuze, what in his last writing he called simply "a life. " They capture a problem that runs throughout his work--his long search for a new and superior empiricism. Announced in his first book, on David Hume, then taking off with his early studies of Nietzsche and Bergson, the problem of an "empiricist conversion" became central to Deleuze's work, in particular to his aesthetics and his conception of the art of cinema. In the new regime of communication and information-machines with which he thought we are confronted today, he came to believe that such a conversion, such an empiricism, such a new art and will-to-art, was what we need most. The last, seemingly minor question of "a life" is thus inseparable from Deleuze's striking image of philosophy not as a wisdom we already possess, but as a pure immanence of what is yet to come. Perhaps the full exploitation of that image, from one of the most original trajectories in contemporary philosophy, is also yet to come.
Impact of Sewage Effluent Amended with the Chlorophyte ScenedesmusQuadricauda or the Cyanophyt Nostoc sp. on Some Metabolic Pools of Wheatand Alfalfa Plants

A pot experiment was conducted to study the influence of various irrigation regimes on some metabolic pools of wheat and alfalfa plants. The photosynthetic pigments and soluble proteins of the tested plants significantly increased when irrigated with sewage amended with Scenedesmus quadricauda or Nostoc sp. On the other hand, soluble carbohydrates decreased in wheat shoots at different treatments except those irrigated with sewage enriched with S. quadricauda. Sewage and that amended with Nostocsp caused promotion of total carbohydrates. Wheat plants with sewage water amended with Nostocspor with mixture of tap water and sewage have an inhibitory effect on free amino acids while alfalfa plants with sewage only enhanced them. Sewage effluent or that reclaimed with S. quadricauda caused significant increase in total lipids content of wheat shoots. In contrast, alfalfa plants exhibited significant decrease at all treatments. This study aimed to determine the effects of amended sewage effluent on metabolic pools of these plants. Estimated pools included the photosynthetic pigments, proteins (soluble and total), carbohydrate (soluble and total), free amino acids and total lipids in shoots of experimental plants
Structure determination of a yeast ribosomal protein L30 and pre-mRNA binding site complex by NMR spectroscopy

The yeast (Saccharomyces cerevisiae) ribosomal protein L30 and its auto-regulatory pre-mRNA binding site provide one of the best examples the critical role of protein-RNA interactions in regulation of RNA processing and control of gene translation. A model system for this interaction, which includes the ribosomal L30 protein and the phylogenetically conserved RNA segment for auto-regulation, was studied using nuclear magnetic resonance (NMR) spectroscopy. The L30 protein recognizes and binds tightly to the stem-internal loop-stem RNA, the recognition elements of which lie mostly on the conserved two-plus-five asymmetric purine-rich internal loop. NMR characterizations were carried out on both the free and bound forms of the protein and the RNA. Detailed analyses of the protein revealed that the main architecture, a fourstranded n-sheet sandwiched between four a-helices, is present both in the free and in the bound form. There are however, substantial local perturbations that accompany RNA binding, the largest of which have been mapped onto the loops connecting Strand A and Helix 2, Strand B and Helix 3, Helix 4 and Strand D. In contrast to the protein, the internal loop of the RNA undergoes significant changes upon complex formation, and the most distinct observation was the formation of the G 11G56 reverse Hoogsteen mismatch pair. Structure modeling using simulated annealing in restrained molecular dynamics was carried out in X-PLOR. Detailed analyses of the complex structure reveal that the protein recognizes the RNA mostly along one side of the internal loop with five purines. The interactions are divided further into two sections. One region consists of mostly aromatic stacking and hydrophobic contacts from Leu25, Phe85 and Val87 of the protein to G56 of the RNA. The other region consists of mostly specific contacts, which include recognition of A57 by Asn 48, and G58 by Arg 52. The L30 proteinRNA complex structure thus determined using NMR spectroscopy not only provides a detailed insight for understanding the structure-function relationship regarding the yeast auto-regulation, it also further demonstrates the important role of the protein-RNA interaction in controlling RNA processing and gene translation. Thesis Supervisor: James R. Williamson Title: Professor of Chemistry
Initial Investigations towards a Flexible Variable Stiffness Single Port System for Partial Nephrectomy

Single port laparoscopic surgeries are the next step towards minimal invasiveness after conventional laparoscopy with several incisions. However, current conventional and single port instruments as well as robotic systems offer only a straight instrument deployment possibility, which results in limited visualization and triangulation. In the particular case of partial nephrectomy the kidney needs to be separated from connected tissues in order to be rotated and thereby improve the visualization and accessibility of the tumor. This preparation procedure demands valuable time of the surgery and in fact increases the invasiveness. In order to prevent these disadvantages we propose a novel, flexible single port manipulator with variable stiffness and instrument deployment channels. We present our vision and conduct first contour accuracy investigations on one segment manipulators with granular jamming.
The Effect of Independent Board of Directors Composition, Independent Audit Committee and Firm Characteristics to The Integrated Reporting Disclosure of The Manufacturing Firms Listed in Indonesian St

This research aims to analyze the effect of independent board of directors composition, independent audit committee, firm characteristics as (firm size and profitability) to the integrated reporting disclosure of the manufacturing firms listed in Indonesian Stock Exchange. The population used in this research consists from 150 firms period 2015-2017. Purposive sampling was implemented in this research. From 150 firms, only 51 firms were selected as research samples. The result showed that Independent audit committee and firm size had positive effect to the integrated reporting disclosure while Independent Board of Directors Composition and profitability had no effect to the integrated reporting disclosure.
Fluorescence Anisotropy Studies on the Ku-DNA Interaction

DNA non-homologous end joining starts with the binding of Ku heterodimers to double strand breaks. In this work, we characterized the thermodynamics of the Ku-DNA interaction by fluorescence anisotropy of the probe-labeled DNA. We determined that the microscopic dissociation constant (kd) for the binding of Ku to a DNA binding site of the proper length (>20 bp) ranges from 22 to 29 nm at 300 mm NaCl. The binding isotherms for DNA duplexes with two or three heterodimers were analyzed with two independent models considering the presence and absence of overlapping binding sites. This analysis demonstrated that there is no or very weak nearest-neighbor cooperativity among the Ku molecules. These models can most likely be applied to study the interaction of Ku with duplexes of any length. Furthermore, our salt dependence studies indicated that electrostatic interactions play a major role in the binding of Ku to DNA and that the kd decreases ∼60-fold as the salt concentration is lowered from 300 to 200 mm. The slope (Γsalt) of the plot of log kd versus log[NaCl] is 12.4 ± 0.1. This value is among the highest reported in the literature for a protein-DNA interaction and suggests that ∼12 ions are released upon formation of the Ku-DNA complex. In addition, comparison of the slope values measured upon varying the type of cation and anion indicated that approximately nine cations and three anions are released from DNA and Ku, respectively, when the complex is formed.
Open source integrated 3D footstep planning framework for humanoid robots

Humanoid robots benefit from their anthropomorphic shape when operating in human-made environments. In order to achieve human-like capabilities, robots must be able to perceive, understand and interact with the surrounding world. Humanoid locomotion in uneven terrain is a challenging task as it requires sophisticated world model generation, motion planning and control algorithms and their integration. In recent years, much progress in world modeling and motion control has been achieved. This paper presents one of the very first open source frameworks for full 3D footstep planning available for ROS which integrates perception and locomotion systems of humanoid bipedal robots. The framework is designed to be used for different type of humanoid robots having different perception and locomotion capabilities with minimal implementation effort. In order to integrate with almost any humanoid walking controller, the system can easily be extended with additional functionality that may be needed by low-level motion algorithms. It also considers sophisticated human-robot interaction that enables to direct the planner to generate improved solutions, provides monitoring data to the operator and debugging feedback for developers. The provided software package consists of three major blocks that address world generation, planning and interfacing low-level motion algorithms. The framework has been successfully applied to four different full-size humanoid robots.
Role of Ran Binding Protein 5 in Nuclear Import and Assembly of the Influenza Virus RNA Polymerase Complex

ABSTRACT The influenza A virus RNA-dependent RNA polymerase is a heterotrimeric complex of polymerase basic protein 1 (PB1), PB2, and polymerase acidic protein (PA) subunits. It performs transcription and replication of the viral RNA genome in the nucleus of infected cells. We have identified a nuclear import factor, Ran binding protein 5 (RanBP5), also known as karyopherin β3, importin β3, or importin 5, as an interactor of the PB1 subunit. RanBP5 interacted with either PB1 alone or with a PB1-PA dimer but not with a PB1-PB2 dimer or the trimeric complex. The interaction between RanBP5 and PB1-PA was disrupted by RanGTP in vitro, allowing PB2 to bind to the PB1-PA dimer to form a functional trimeric RNA polymerase complex. We propose a model in which RanBP5 acts as an import factor for the newly synthesized polymerase by targeting the PB1-PA dimer to the nucleus. In agreement with this model, small interfering RNA (siRNA)-mediated knock-down of RanBP5 inhibited the nuclear accumulation of the PB1-PA dimer. Moreover, siRNA knock-down of RanBP5 resulted in the delayed accumulation of viral RNAs in infected cells, confirming that RanBP5 plays a biological role during the influenza virus life cycle.
Investor Communication and the Benefits of Cross-Listing

Abstract While studies have sought to explain the benefits of cross-listing, little attention has been paid to the role of communication between managers and investors during this process. In this paper, I investigate whether managers change communication policies around U.S. cross-listings. I document significant increases in communication when firms cross-list. I then test whether these investor communication practices around cross-listing are associated with capital market benefits. I find that cross-listed firms that communicate more with investors experience greater and longer lasting cross-listing benefits. Lastly, I explore two potential reasons that may lead managers to choose higher levels of communication: to support an increase in investor recognition and to facilitate monitoring. I find results consistent with communication increasing visibility and scrutiny, suggesting that communication functions as a supporting tool to achieve managers’ cross-listing goals.
A History of Growth Hormone Injection Devices

In the early 1960s, growth hormone (GH) deficiency was treated by intramuscular injection of GH extracted from human pituitary glands. Since then, there have been many advances in treatment encompassing the route of administration, the injection product and the injection device. This review considers the advances in injection device that have already taken place and how they have benefited the patient, particularly in terms of reduced pain and improved convenience. In the future, needle-free injection techniques and depot formulations of GH are likely to offer alternatives to daily subcutaneous injections.