Miracle-dz/UniFAR-FTUs huggingface dataset:
Cell Broadband Engine processor vault security architecture

Current data protection technologies such as those based on public-key encryption and broadcast encryption focus on the secure control and protection of data. Although these protection schemes are effective and mathematically sound, they are susceptible to systematic attacks that utilize any underlying platform weakness, bypassing the cryptographic strengths of the actual schemes. Thus, ensuring that the computing platform supports the cryptographic data protection layers is a critical issue. The Cell Broadband Engine™ (Cell/B.E.) processor security architecture has three core features that are well suited for this purpose. It provides hardware-enforced process isolation in which code and data can execute in physically isolated memory space. It also provides the ability to perform hardware-supported authentication of any software stack (i.e., "secure boot") during runtime. Finally, the architecture provides a hardware key to act as the root of an encryption chain. Data encrypted directly or indirectly by this key can be decrypted and provided only to an application that is running in the isolated memory and that has been verified. This significantly reduces an adversary's chances of manipulating software to expose the key that is fundamental to a data protection or authentication scheme. Furthermore, it provides a foundation for an application to attest itself to a remote party by demonstrating access to a secret.
Collective norms of engagement link to individual engagement

Purpose – The purpose of this paper is to apply a group norm approach to explain how average engagement across an organization is related to an individual’s level of engagement. Design/methodology/approach – Survey data were collected from over 46,000 participants from 140 organizations. Multi-level analysis tested the hypotheses that similarity (in terms of shared status) and likely interaction would determine the extent a group’s norms affected individual engagement. Normative data and the dependent variable data were provided by different participants. Findings – Results supported the aggregation of individuals’ measure of engagement to form three norms within an organization: an employee norm, a manager norm and a senior leader norm. These engagement norms were significantly related to an individual’s engagement at work beyond the effect of both organizational resources and manager support. Individuals were more strongly influenced by the norm of those in the organization with whom they were most simi.
Molecular Analysis of RNF213 Gene for Moyamoya Disease in the Chinese Han Population

Background Moyamoya disease (MMD) is an uncommon cerebrovascular disorder characterized by progressive occlusion of the internal carotid artery causing cerebral ischemia and hemorrhage. Genetic factors in the etiology and pathogenesis of MMD are being increasingly recognized. Previous studies have shown that the RNF213 gene was related to MMD susceptibility in the Japanese population. However, there is no large scale study of the association between this gene and MMD in the Chinese Han population. Thus we designed this case-control study to validate the R4810K mutation and to define the further spectrum of RNF213 mutations in Han Chinese. Methodology/Principal Findings Genotyping of the R4810K mutation in the RNF213 gene was performed in 170 MMD cases and 507 controls from a Chinese Han population. The R4810K mutation was identified in 22 of 170 MMD cases (13%), including 21 heterozygotes and a single familial homozygote. Two of the 507 controls (0.4%) were heterozygous R4810K carriers. The R4810K mutation greatly increased the risk for MMD (OR = 36.7, 95% CI: 8.6∼156.6, P = 6.1 E-15). The allele frequency of R4810K was significantly different between patients with ischemia and hemorrhage (OR = 5.4, 95% CI: 1.8∼16.1, P = 0.001). Genomic sequencing covering RNF213 exon 40 to exon 68 also identified eight other non-R4810K variants; P4007R, Q4367L, A4399T, T4586P, L4631V, E4950D, A5021V and M5136I. Among them A4399T polymorphism was found in 28/170 cases (16.5%) and 45/507 controls (8.9%) and was associated with MMD (OR = 2.0, 95% CI: 1.2∼3.3, P = 0.004), especially with hemorrhage (OR = 2.8, 95% CI: 1.2∼6.5, P = 0.014). Conclusions RNF213 mutations are associated with MMD susceptibility in Han Chinese. The ischemic type MMD is particularly related to the R4810K mutation. However, A4399T is also a susceptible variant for MMD, primarily associated with hemorrhage. Identification of novel variants in the RNF213 gene further highlights the genetic heterogeneity of MMD.
A rationale for positive online content for children

The child/media relationship is an entry point into the wide and multifaceted world of children and their rights--to education, freedom of expression, play, identity, health, dignity and self-respect, protection. in every aspect of child rights, in every element of the life of a child, the relationship between children and the media plays a role.
AS160 Phosphotyrosine-binding Domain Constructs Inhibit Insulin-stimulated GLUT4 Vesicle Fusion with the Plasma Membrane*

AS160 (TBC1D4) is a known Akt substrate that is phosphorylated downstream of insulin action and that leads to regulated traffic of GLUT4. As GLUT4 vesicle fusion with the plasma membrane is a highly regulated step in GLUT4 traffic, we investigated whether AS160 and 14-3-3 interactions are involved in this process. Fusion was inhibited by a human truncated AS160 variant that encompasses the first N-terminal phosphotyrosine-binding (PTB) domain, by either of the two N-terminal PTB domains, and by a tandem construct of both PTB domains of rat AS160. We also found that in vitro GLUT4 vesicle fusion was strongly inhibited by the 14-3-3-quenching inhibitors R18 and fusicoccin. To investigate the mode of interaction of AS160 and 14-3-3, we examined insulin-dependent increases in the levels of these proteins on GLUT4 vesicles. 14-3-3γ was enriched on insulin-stimulated vesicles, and its binding to AS160 on GLUT4 vesicles was inhibited by the AS160 tandem PTB domain construct. These data suggest a model for PTB domain action on GLUT4 vesicle fusion in which these constructs inhibit insulin-stimulated 14-3-3γ interaction with AS160 rather than AS160 phosphorylation.
Platform-level Distributed Warfare Model-based on Multi-Agent System Framework

The multi-agent paradigm has become a useful tool in solving military problems. However, one of key challenges in multi-agent model for distributed warfare could be how to describe the microcosmic tactical warfare platforms actions. In this paper, a platform-level distributed warfare model based on multi-agent system framework is designed to tackle this challenge. The basic ideas include: Establishing multi-agent model by mapping from tactical warfare system’s members, i.e., warfare platforms, to respective agents; performing task decomposition and task allocation by using task-tree decomposition method and improved contract net protocol model technique; and implementing simulation by presenting battlefield terrain environment analysis algorithm based on grid approach. The simulation demonstration results show that our model provides a feasible and effective approach to supporting the abstraction and representation of microcosmic tactical actions for complex warfare system. Defence Science Journal, 2012, 62(1), pp.180-186 , DOI:http://dx.doi. org/10.14429/dsj.62. 964
Gene Expression Profiling of Muscle Stem Cells Identifies Novel Regulators of Postnatal Myogenesis

Skeletal muscle growth and regeneration require a population of muscle stem cells, the satellite cells, located in close contact to the myofiber. These cells are specified during fetal and early postnatal development in mice from a Pax3/7 population of embryonic progenitor cells. As little is known about the genetic control of their formation and maintenance, we performed a genome-wide chronological expression profile identifying the dynamic transcriptomic changes involved in establishment of muscle stem cells through life, and acquisition of muscle stem cell properties. We have identified multiple genes and pathways associated with satellite cell formation, including set of genes specifically induced (EphA1, EphA2, EfnA1, EphB1, Zbtb4, Zbtb20) or inhibited (EphA3, EphA4, EphA7, EfnA2, EfnA3, EfnA4, EfnA5, EphB2, EphB3, EphB4, EfnBs, Zfp354c, Zcchc5, Hmga2) in adult stem cells. Ephrin receptors and ephrins ligands have been implicated in cell migration and guidance in many tissues including skeletal muscle. Here we show that Ephrin receptors and ephrins ligands are also involved in regulating the adult myogenic program. Strikingly, impairment of EPHB1 function in satellite cells leads to increased differentiation at the expense of self-renewal in isolated myofiber cultures. In addition, we identified new transcription factors, including several zinc finger proteins. ZFP354C and ZCCHC5 decreased self-renewal capacity when overexpressed, whereas ZBTB4 increased it, and ZBTB20 induced myogenic progression. The architectural and transcriptional regulator HMGA2 was involved in satellite cell activation. Together, our study shows that transcriptome profiling coupled with myofiber culture analysis, provides an efficient system to identify and validate candidate genes implicated in establishment/maintenance of muscle stem cells. Furthermore, tour de force transcriptomic profiling provides a wealth of data to inform for future stem cell-based muscle therapies.
Comprehensive Method for the Typing of HLA‐A, B, and C Alleles by Direct Sequencing of PCR Products Obtained from Genomic DNA

Molecular testing is gradually replacing standard typing techniques in the field of HLA because it allows higher resolution, which has significant functional implications. Although several techniques have been so far described for this purpose, the definitive means to determine which alleles are present in a particular sample is to identify their sequence. We describe a simplified method for typing HLA-A, B, and C alleles by direct sequencing of polymerase chain reaction (PCR) products amplified from genomic DNA that could allow large-scale handling of samples for clinical use. The template is the product of a nested PCR. A first round of PCR amplifications from genomic DNA is performed with three different sets of primers, one pair specific for each locus. The PCR products encompass exons 2 and 3, the regions of interest to determine the allele present. These fragments are a mixture of both alleles present in one locus. In a second round of PCRs using the first fragment as template, exons 2 and 3 are separately amplified and simultaneously tailed with sequences corresponding to fluorescent-labeled commercial primers. The sense and antisense sequence of each exon is obtained and compared with a database of all known HLA-A, B, or C alleles. Heterozygous positions are determined and the most probable alleles assigned. This simplified procedure has the practical advantage of allowing high-resolution typing of clinical material by utilizing the same genomic DNA used for standard molecular typing of HLA class I.
A comparison of single- and multi-hop beaconing in VANETs

Optimizing vehicular communication strategies is important for an efficient usage of the available wireless bandwidth and also critical for the success of VANETs. In this paper we address the fundamental and practical question whether the load on the wireless channel can be reduced if periodic beacon messages are transmitted over multiple hops with reduced transmit power instead of being transmitted over one hop with high transmit power. In particular, we look at the possible bandwidth savings that can be achieved by piggybacking forwarded messages into the own next beacon transmission. For that matter, we first propose an analytical model to compute a lower bound for the resulting channel load when single- or multi-hop dissemination of beacons is performed. In this model we assume optimal channel conditions and perfect relaying and piggybacking decisions to show that a reduction of the load by multi-hop is possible and closely related to piggybacking. Further, we show that the possible savings depend on the ratio between the size of the header and the payload of a beacon and that a reduction of the load is theoretically possible if the header is larger than the payload - what would be the case in VANETs if security overheads are considered part of the header. We then perform a simulative comparison of single- and multi-hop beaconing to evaluate the impact of effects such as packet collisions and channel fading. We show that the possible savings of multi-hop beaconing are difficult to exploit under non-perfect channel conditions and suboptimal relaying decisions.
Successive interference cancellation in full duplex cellular networks

Through the self interference cancellation, the emerging full duplex (FD) technology possesses the potential to double the link capacity of wireless cellular networks. However, under the simultaneous uplink and downlink transmission in the same band, the co-channel interference (CCI) remains in FD cellular networks is becoming a prominent obstacle for FD performance improvement. In this paper, a novel co-channel interference cancellation (CCIC) scheme is proposed to improve the spectrum efficiency by cancelling CCI in FD cellular networks. Based on the CCIC scheme, the upper bound of the instantaneous end-to-end equivalent link capacity in a FD cellular network is derived. Then we provide a new closed-form expression for the general successful transmission probability that captures the joint effect of CCI and residual self-interference (RSI). The accurate match between simulation and theoretical results can verify the derivation. Besides, the obtained results indicate that the successful transmission probability under CCIC scheme increases with the decline of the channel fading which significantly outperforms the conventional FD schemes.
Energy Efficient Resource Allocation for OFDMA Full Duplex Distributed Antenna Systems with Energy Recycling

In this paper, we consider an orthogonal frequency division multiple access based full duplex distributed antenna system (FDDAS) with energy recycling capability and develop an energy efficient resource allocation scheme for such system. In particular, in order to optimize the energy efficiency of FDDAS, we formulate the problem of joint subchannel allocation and power control as a mixed integer nonlinear programming problem. Since the formulated optimization problem is a NP-hard problem whose computation complexity will rise exponentially with larger network scale, we develop a low complexity subchannel allocation and power control algorithm. The convergence property of the proposed algorithm is established. Simulation results show that the proposed algorithm for FDDAS results in a higher system energy efficiency than the existing algorithm for distributed antenna systems without energy recycling capability.
Noninvasive fetal ECG estimation based on linear transformations

This year's PhysioNet challenge consists of locating fetal QRS complexes and estimating QT interval in fetal electrocardiographic (FECG) recordings. The approach presented in this work is based on linear transformations obtained from techniques such as independent (ICA), periodic (πCA) and principal components analysis (PCA). The algorithm consists in a common ECG preprocessing stage, followed by a maternal ECG (MECG) removal, obtaining a preprocessed signal. This preprocessed signal is then rotated by PCA, πCA and ICA, in order to get a more clear representation of the fetal activity. Then QRS complexes are detected in these three signal representations. An statistical model, trained in set A, is applied to the detections obtained from the 12 resulting leads, in order to rank the leads according to their FECG content. With the detections of those leads, an average QRS complex is calculated with the Woody algorithm, and an algorithm for the refinement of the fetal QRS detections (fQRS) is used to end the procedure. An estimation of the SNR gain produced by coherent averaging is used to decide the final validity of the fQRS measurements. For those valid recordings, the QT interval is measured in an average heartbeat, calculated by coherent averaging over all the fQRS. Results in set B were 4714.6 for event 4, and 121.6 for event 5. In conclusion, due to the poor generalization capability of the algorithm, the strategy must be further improved to properly extract FECG.
Fast speaker adaptation using non-negative matrix factorization

This paper describes a new method for fast speaker adaptation in large vocabulary recognition systems. As in most HMM-based recognizers, the observation densities are modeled as a weighted sum of Gaussian densities. Instead of adapting the means of the Gaussian densities, which is typically done, the weights for the Gaussian densities in the states are adapted. By applying non-negative matrix factorization (NMF) in the proposed method, very fast adaptation was achieved. Experiments on the Wall Street Journal benchmark recognition task show relative improvements between 5% and 15%, while the adaptation converges within 0.2 seconds. Analysis of the latent speakers found by NMF learns that these latent speakers reflect the gender of the speaker most prominently, even when vocal tract length normalization is used, and that they reflect the speaker's age more clearly than the speaker's regional influences or dialect.
ADAPTIVE QUERY PROCESSING FOR DATA AGGREGATION: MINING, USING AND MAINTAINING SOURCE STATISTICS

Most data integration systems focus on “data aggregation” applications, where individual data sources all export fragments of a single relation. Given a query, the primary query processing objective is to select the appropriate subset of sources to optimize conflicting user preferences. We develop an adaptive data aggregation framework to effectively gather and maintain source statistics and use them to support multi-objective source selection. We leverage the existing techniques in learning source coverage/overlap statistics, and develop novel approaches to collect query sensitive source density and latency statistics. These statistics can be used to optimize the coverage, density and latency objectives during source selection. We present a joint optimization model that supports a spectrum of trade-offs between these objectives. We also present efficient online learning techniques to incrementally maintain source statistics.
The illustrated manual of sex therapy

List of Illustrations. Introduction to the Second Edition. Introduction. The Concept of Sex Therapy. Part I: Basic Issues. The nature and Causes of Sexual Dysfunctions. The Sexual Evaluation. Part II: The Sexual Exercises: A. An Erotic Technique Used for Many Dysfunctions. Sensate Focus I - Pleasuring. Sensate Focus II - Genital Pleasuring. B. Erotic Techniques Used for Specific Dysfunctions. Frigidity - Female Sexual Unresponsiveness. Female Orgastic Dysfunction. Vaginismus. Impotence - Erectile Dysfunction. Retarded Ejaculation - Ejaculatory - Overcontrol. Premature Ejaculation - Inadequate Ejaculatory Control. Part III: Conclusions. The Role of Psychodynamics in Sex Therapy.
The complete genome sequence for putative H₂- and S-oxidizer Candidatus Sulfuricurvum sp., assembled de novo from an aquifer-derived metagenome.

We reconstructed the complete 2.4 Mb-long genome of a previously uncultivated epsilonproteobacterium, Candidatus Sulfuricurvum sp. RIFRC-1, via assembly of short-read shotgun metagenomic data using a complexity reduction approach. Genome-based comparisons indicate the bacterium is a novel species within the Sulfuricurvum genus, which contains one cultivated representative, S. kujiense. Divergence between the species appears due in part to extensive genomic rearrangements, gene loss and chromosomal versus plasmid encoding of certain (respiratory) genes by RIFRC-1. Deoxyribonucleic acid for the genome was obtained from terrestrial aquifer sediment, in which RIFRC-1 comprised ∼ 47% of the bacterial community. Genomic evidence suggests RIFRC-1 is a chemolithoautotrophic diazotroph capable of deriving energy for growth by microaerobic or nitrate-/nitric oxide-dependent oxidation of S°, sulfide or sulfite or H₂oxidation. Carbon may be fixed via the reductive tricarboxylic acid cycle. Consistent with these physiological attributes, the local aquifer was microoxic with small concentrations of available nitrate, small but elevated concentrations of reduced sulfur and NH(4)(+) /NH₃-limited. Additionally, various mechanisms for heavy metal and metalloid tolerance and virulence point to a lifestyle well-adapted for metal(loid)-rich environments and a shared evolutionary past with pathogenic Epsilonproteobacteria. Results expand upon recent findings highlighting the potential importance of sulfur and hydrogen metabolism in the terrestrial subsurface.
Assessment of coyote–wolf–dog admixture using ancestry‐informative diagnostic SNPs

The evolutionary importance of hybridization as a source of new adaptive genetic variation is rapidly gaining recognition. Hybridization between coyotes and wolves may have introduced adaptive alleles into the coyote gene pool that facilitated an expansion in their geographic range and dietary niche. Furthermore, hybridization between coyotes and domestic dogs may facilitate adaptation to human‐dominated environments. We genotyped 63 ancestry‐informative single‐nucleotide polymorphisms in 427 canids to examine the prevalence, spatial distribution and the ecology of admixture in eastern coyotes. Using multivariate methods and Bayesian clustering analyses, we estimated the relative contributions of western coyotes, western and eastern wolves, and domestic dogs to the admixed ancestry of Ohio and eastern coyotes. We found that eastern coyotes form an extensive hybrid swarm, with all our samples having varying levels of admixture. Ohio coyotes, previously thought to be free of admixture, are also highly admixed with wolves and dogs. Coyotes in areas of high deer density are genetically more wolf‐like, suggesting that natural selection for wolf‐like traits may result in local adaptation at a fine geographic scale. Our results, in light of other previously published studies of admixture in Canis, revealed a pattern of sex‐biased hybridization, presumably generated by male wolves and dogs mating with female coyotes. This study is the most comprehensive genetic survey of admixture in eastern coyotes and demonstrates that the frequency and scope of hybridization can be quantified with relatively few ancestry‐informative markers.