Miracle-dz/UniFAR-FTUs huggingface dataset:
Distribution of keratins, vimentin, and actin in the testis of two South American camelids: Vicuna (Vicugna vicugna) and llama (Lama glama). An immunohistochemical study

The purpose of the present study was to investigate the pattern of distribution of cytokeratins, vimentin and muscular actin in the testis of vicuna (Vicugna vicugna) and llama (Lama glama) two species of camelids native of the Andean high plateau of South America.
Carrier frequency offset estimation and FPGA implementation in OFDM system

The carrier frequency offset(CFO) in OFDM system is one of the key factors that affect the performance of wireless communication. Based on the analysis of the CFO estimation algorithm, this paper presents FPGA implementation scheme in the problem of OFDM fractional CFO estimation using pilot-based algorithm, including CFO estimation and CFO compensation. The circuit modules in the program were written in Verilog HDL. They are compiled, simulated and integrated under Xilinx programming software Vivado 2014.4. The simulation results show that the circuit module can accurately estimate and compensate the fractional CFO.
Systematic review of the literature on characteristics of late-talking toddlers.

BACKGROUND Research has investigated late-talking toddlers because they are at great risk of continuing to experience language-learning difficulties once they enter school and hence are candidates for early intervention. It is also important to consider this group of children with regards to the immediate characteristics which are detrimental to their development and for which early intervention has become increasingly available. AIMS To review the literature on late-talking toddlers in order to identify the characteristics of this population whose importance has been clearly demonstrated, identify sources of incongruence in findings, and to underscore aspects of language delay at 2 years of age and characteristics about which additional knowledge is needed. MAIN CONTRIBUTION The review highlights the need to define the language difficulties found in late-talking toddlers based on clinical profiles that go beyond the criterion of an expressive vocabulary delay. It also underscores the association between vocabulary delay and characteristics of the child such as social-emotional development and characteristics of the socio-familial environment such as language stimulation. CONCLUSIONS Future research should take into account the lack of homogeneity observed within the population of children with a vocabulary delay at 2 years of age and attempt to identify subgroups within late-talking toddlers. It should also consider a multifactorial perspective of child development to further the understanding of this phenomenon.
Theory of rheology in confinement.

The viscosity of fluids is generally understood in terms of kinetic mechanisms, i.e., particle collisions, or thermodynamic ones as imposed through structural distortions upon, e.g., applying shear. Often the latter are more relevant, which allows a simpler theoretical description, and, e.g., (damped) Brownian particles can be considered good fluid model systems. We formulate a general theoretical approach for rheology in confinement, based on microscopic equations of motion and classical density functional theory. Specifically, we discuss the viscosity for the case of two parallel walls in relative motion as a function of the wall-to-wall distance, analyzing its relation to the slip length found for a single wall. The previously observed [A. A. Aerov and M. Krüger, J. Chem. Phys. 140, 094701 (2014). ] deficiency of inhomogeneous (unphysical) stresses under naive application of shear in confinement is healed when hydrodynamic interactions are included.
Toward a Yin-Yang Balancing Perspective of Relational (Guanxi) Gatekeeping in International Exchange Relationships in China

China is an extremely complex and “insider-controlled” market for foreign businesses. This study offers a yin-yang balancing perspective of international exchange relationships in China. The authors investigate how “relational gatekeepers” play a key role in achieving a dynamic balance between Western companies and local partners in international exchange relationships. In-depth interviews are conducted with 41 business managers based in China, Australia, and New Zealand. Guided by the yin-yang balancing frame, the authors develop four key constructs of relational gatekeeping: the gatekeeper resources of mianzi (insider status) and renqing (insider favor) and the gatekeeper capabilities of zao shi (creating favorable momentum) and ying shi (leveraging favorable momentum). The yin-yang frame provides a process view of business relationships that accepts paradoxical conditions and embraces dynamic network momentum, resources, and capabilities. The study concludes by showing the theoretical implications for network theory and for the field of dynamic balancing and suggests the managerial implications for an international company aiming to engage relational gatekeepers to break into insider (guanxi)-controlled local business networks.
Separate Medication Preparation Rooms Reduce Interruptions and Medication Errors in the Hospital Setting: A Prospective Observational Study

Supplemental digital content is available in the text. Background Interruptions and errors during the medication process are common, but published literature shows no evidence supporting whether separate medication rooms are an effective single intervention in reducing interruptions and errors during medication preparation in hospitals. We tested the hypothesis that the rate of interruptions and reported medication errors would decrease as a result of the introduction of separate medication rooms. Aim Our aim was to evaluate the effect of separate medication rooms on interruptions during medication preparation and on self-reported medication error rates. Methods We performed a preintervention and postintervention study using direct structured observation of nurses during medication preparation and daily structured medication error self-reporting of nurses by questionnaires in 2 wards at a major teaching hospital in Switzerland. Results A volunteer sample of 42 nurses was observed preparing 1498 medications for 366 patients over 17 hours preintervention and postintervention on both wards. During 122 days, nurses completed 694 reporting sheets containing 208 medication errors. After the introduction of the separate medication room, the mean interruption rate decreased significantly from 51.8 to 30 interruptions per hour (P < 0.01), and the interruption-free preparation time increased significantly from 1.4 to 2.5 minutes (P < 0.05). Overall, the mean medication error rate per day was also significantly reduced after implementation of the separate medication room from 1.3 to 0.9 errors per day (P < 0.05). Conclusions The present study showed the positive effect of a hospital-based intervention; after the introduction of the separate medication room, the interruption and medication error rates decreased significantly.
Commercialization of high 600V GaN-on-silicon power HEMTs and diodes

With power conversion losses endemic in all areas of electricity consumption, broadly categorized into motion control (accounting for around 50% of total electrical energy use), lighting, air conditioning, and information technology, consumers, governments and utilities are finding ways to achieve higher efficiency. Manufacturers of data servers, telecom systems, solar power inverters and drives for motor control are focused on reducing power conversion losses while simultaneously shrinking the size of power systems. Although silicon has historically been the base device material used by the power conversion industry, it is rapidly reaching its physical performance limits. GaN semiconductors solutions reduce power conversion loss by over 50% in a significantly smaller form factor and at a lower cost, when device design, fabrication technology and application design are holistically combined to deliver superior end products.
Impact of Credit on Education and Healthcare Spending in Rural Pakistan

It is to access that the microcredit has a positive impact on education and healthcare spending of the borrowed households is controversial in developing countries literature or not. This study reports evidence, from Pakistan for this debate, while utilising data from PPHS-2010 (Pakistan Panel Household Survey). Propensity score matching (PSM) has been used to investigate the impact of household credit on healthcare and education spending by the poor. In addition to matching statistically identical borrowers with non-borrowers, the method controls for household pre-treatment assets and income. These may be correlated with unobservable factors affecting credit participation as well as outcomes of interest. The estimates from binary as well as multiple ordered treatment effect show insignificant impact of borrowing on education and significant and positive impact on healthcare spending.
Commodity prices and the AUD-Yen exchange rate: a real-time forecasting analysis

ABSTRACT I study the impact of the GSCI commodity price indices on the Australian dollar-Japanese yen nominal exchange rate using a modified version of the classic monetary approach of exchange rate determination. I use a broad range of model-selection and model-averaging criteria. I find some evidence for a short-lived relationship as far as inclusions in the optimal forecasting models are concerned. In general, though, results of the Diebold-Mariano and Clark-West test show that results are not stable over the whole sample.
Roles of alpha-toxin and beta-toxin in virulence of Staphylococcus aureus for the mouse mammary gland

Mutants of Staphylococcus aureus which fail to express alpha-toxin (Hly), beta-toxin (Hlb), or both have been constructed by site-specific mutagenesis. The virulence of the mutants was compared with that of wild-type toxigenic strains by intramammary inoculation of lactating mice. A bovine strain, M60, and a laboratory strain, 8325-4, caused acute mastitis and death within 48 h for 60% of the mice inoculated. Animals inoculated with Hly mutants also developed acute mastitis, but no deaths occurred. Comparisons of Hly- or Hlb-positive strains with the double mutation Hly Hlb showed that both toxins led to a significantly higher recovery of S. aureus from the gland 48 h postinfection. Histopathological examination of mammary glands showed that phagocytosis of bacteria occurred irrespective of toxigenicity, but toxigenic strains, particularly those which were Hly+, continued to multiply, invaded the interalveolar tissues, and produced severe lesions. Stimulation of an inflammatory response by inoculation of the mammary gland with endotoxin prior to challenge with S. aureus reduced recovery of the bacteria 10- to 100-fold and, under these conditions, neither alpha-toxin nor beta-toxin contributed significantly to growth and survival.
X‐ray crystallographic analysis of the complexes of enoyl acyl carrier protein reductase of Plasmodium falciparum with triclosan variants to elucidate the importance of different functional groups in enzyme inhibition

Triclosan, a well‐known inhibitor of Enoyl Acyl Carrier Protein Reductase (ENR) from several pathogenic organisms, is a promising lead compound to design effective drugs. We have solved the X‐ray crystal structures of Plasmodium falciparum ENR in complex with triclosan variants having different substituted and unsubstituted groups at different key functional locations. The structures revealed that 4 and 2′ substituted compounds have more interactions with the protein, cofactor, and solvents when compared with triclosan. New water molecules were found to interact with some of these inhibitors. Substitution at the 2′ position of triclosan caused the relocation of a conserved water molecule, leading to an additional hydrogen bond with the inhibitor. This observation can help in conserved water‐based inhibitor design. 2′ and 4′ unsubstituted compounds showed a movement away from the hydrophobic pocket to compensate for the interactions made by the halogen groups of triclosan. This compound also makes additional interactions with the protein and cofactor which compensate for the lost interactions due to the unsubstitution at 2′ and 4′. In cell culture, this inhibitor shows less potency, which indicates that the chlorines at 2′ and 4′ positions increase the ability of the inhibitor to cross multilayered membranes. This knowledge helps us to modify the different functional groups of triclosan to get more potent inhibitors. © 2010 IUBMB IUBMB Life, 467–476, 2010
Autobiographical Memory in the Angry Self

The impact of anger on autobiographical recall was examined in two studies. In Experiment 1, 76 participants differing in trait anger completed an autobiographical memory task (AMT). In Experiment 2, 50 participants with elevated trait anger were either provoked or not provoked and subsequently completed an AMT. Across both studies, participants with high dispositional anger reported more anger-related memories, describing themselves as the primary agent of anger. In Experiment 2, provoked participants reported more memories describing themselves as the target of anger. These findings highlight the distinct patterns of memory recall associated with trait versus state anger. Findings are discussed in terms of retrieval biases operating in angry individuals and proposals stemming from self-memory system models of autobiographical memory.
Crystal structures of ferrous horse heart myoglobin complexed with nitric oxide and nitrosoethane

The interactions of nitric oxide (NO) and organic nitroso compounds with heme proteins are biologically important, and adduct formation between NO‐containing compounds and myoglobin (Mb) have served as prototypical systems for studies of these interactions. We have prepared crystals of horse heart (hh) MbNO from nitrosylation of aqua‐metMb crystals, and we have determined the crystal structure of hh MbNO at a resolution of 1.9 Å. The Fe‐N‐O angle of 147° in hh MbNO is larger than the corresponding 112° angle previously determined from the crystal structure of sperm whale MbNO (Brucker et al., Proteins 1998;30:352–356) but is similar to the 150° angle determined from a MS XAFS study of a frozen solution of hh MbNO (Rich et al., J Am Chem Soc 1998;120:10827–10836). The Fe‐N(O) bond length of 2.0 Å (this work) is longer than the 1.75 Å distance determined from the XAFS study and suggests distal pocket influences on FeNO geometry. The nitrosyl N atom is located 3.0 Å from the imidazole Nϵ atom of the distal His64 residue, suggesting electrostatic stabilization of the FeNO moiety by His64. The crystal structure of the nitrosoethane adduct of ferrous hh Mb was determined at a resolution of 1.7 Å. The nitroso O atom of the EtNO ligand is located 2.7 Å from the imidazole Nϵ atom of His64, suggesting a hydrogen bond interaction between these groups. To the best of our knowledge, the crystal structure of hh Mb(EtNO) is the first such determination of a nitrosoalkane adduct of a heme protein. Proteins 2003. © 2003 Wiley‐Liss, Inc.
A Time Delay Controller for Systems with Unknown Dynamics

This paper focuses on the control of systems with unknown dynamics and deals with the class of systems described by ¿=f(x,t)+h(x,t)+B(x,t)u+d(t) where h(x,t) and d(t) are unknown dynamics and unexpected disturbances, respectively. A new control method, Time Delay Control (TDC), is proposed for such systems. Under the assumption of accessibility to all the state variables and their derivatives, the TDC is characterized by a simple estimation technique of the effect of the uncertainties. This is accomplished using time delay. The control system's structure, stability and design issues are discussed for linear time-invariant and single-input- single-output systems. Finally, the control performance was evaluated through both simulations and experiments. The theoretical and experimental results indicate that this control method shows excellent robustness properties to unknown dynamics and disturbances.
Simultaneous optical interrogation of multiple tuning fork resonators using range-resolved interferometry

In a proof-of-principle experiment, the vibrations of a set of three tuning folk resonators are simultaneously interrogated along a single optical beam using range-resolved interferometry. Measurements with noise standard deviations in the nm levels over bandwidths of many kHz are possible. In addition, a high degree of environmental noise rejection is inherently achievable because only differential measurements between the vibrating tuning folk prong pairs are evaluated. Employing only highly coherent, robust and cost-effective diode lasers, this approach could be useful for a wide range of mechanical sensor interrogation tasks.
The role of sustainable environment attributes in luxury product perceptions: Evidence from an emerging market

Abstract The social responsibility aspect of the luxury product concept has recently started to receive more attention from researchers and practitioners. However, the luxury product perceptions measurement in the literature often does not incorporate the sustainable environment friendly dimensions of the luxury goods consumption. Therefore in this study, we attempt to investigate the role of sustainable environment benefits in consumers’ value perceptions of the luxury products. Data for the study was collected from n = 218 female consumers who were shopping in high-end luxury apparel retailers located in exclusive shopping centers in Turkey. Study results show four dimensions (exclusiveness, normative beliefs, self-directed pleasure, and social/prestige) of luxury goods perceptions of female Turkish consumers. Practical and research implications of the study findings are presented.
Semantic web user interactions: exploring hci challenges

The purpose of this workshop is to engage interaction researchers and designers in the user interaction challenges posed by the Semantic Web. The workshop will be the fifth workshop in the SWUI series - it has previously been hosted at either the World Wide Web Conference or the International Semantic Web Conference. We have sufficient exemplars of both tools and approaches now that we can demonstrate the concepts of the space to participants and make it very clear why there are design/research challenges for the CHI community. We want to explore current and future CHI research that fits this problem space, and so invite participants exploring many interaction issues.
A Nonparametric Test for Comparing Valuation Distributions in First‐Price Auctions

This article proposes a nonparametric test for comparing valuation distributions in first‐price auctions. Our test is motivated by the fact that two valuation distributions are the same if and only if their integrated quantile functions are the same. Our method avoids estimating unobserved valuations and does not require smooth estimation of bid density. We show that our test is consistent against all fixed alternatives and has nontrivial power against root‐N local alternatives. Monte Carlo experiments show that our test performs well in finite samples. We implement our method on data from U.S. Forest Service timber auctions.
An ANN based approach for wireless device fingerprinting

Device fingerprinting is a technique to characterize or identify a device by using collected information about the device. Wireless device fingerprinting plays an important role in finding counterfeit devices in a wireless network. Fingerprinting methods can be active by sending some information to the target device; or by observing the information sent by the target device which is known as passive fingerprinting. In this paper, a technique of fingerprinting wireless devices based on Artificial Neural Networks has been presented. The parameters used in our work are transmission time and frame inter-arrival time. Our technique classifies unique devices from GTID and Sigcomm2008 datasets using frame inter-arrival time and transmission time and then the results are presented. Using these technique accuracies of 92.3% and 95.8% have been achieved by considering inter-arrival time and transmission time respectively.
Protein SUMOylation, an emerging pathway in amyotrophic lateral sclerosis

The covalent attachment of SUMO proteins (small ubiquitin-like modifier) to specific proteins or SUMOylation regulates their functional properties in the nucleus and cytoplasm of neurons. Recent studies reported dysfunction of the SUMO pathway in molecular and cellular abnormalities associated with amyotrophic lateral sclerosis (ALS). Furthermore, several observations support a direct role for SUMOylation in diverse pathogenic mechanisms involved in ALS, such as response to hypoxia, oxidative stress, glutamate excitotoxicity and proteasome impairment. Recent results also suggest that SUMO modifications of superoxide dismutase 1, transactive response DNA-binding protein 43, CTE (COOH terminus of EAAT2) (proteolytic C-terminal fragment of the glutamate transporter excitatory amino acid transporter 2, EAAT2) and proteins regulating the turnover of ALS-related proteins can participate in the pathogenesis of ALS. Moreover, the fused in sarcoma (FUS) gene, mutated in ALS, encodes a protein with a SUMO E3 ligase activity. In this review, we summarize the functioning of the SUMO pathway in normal conditions and in response to stresses, its action on ALS-related proteins and discuss the need for further research on this pathway in ALS.
Property Rights Restrictions and Housing Prices

Using a natural experiment in Singapore, we examine the economic impact of temporarily restricting owners’ rights to transfer their property. Executive condominiums (ECs), introduced to provide affordable housing for middle-class citizens, are subject to restrictions on transferability in the first 10 years, unlike private condominiums (PCs). As per the option theory, EC buyers have the forward-start American put option with the right to sell their properties only after the contract date. Among transacted units matched by location, completion and transaction dates, and complex- and unit-level characteristics, we find that prices of new ECs are about 21 percent lower than those of PCs. After the 10th year, when property rights restrictions are completely removed, the price gap between ECs and PCs narrows to about 3 percent. These results suggest that property rights restrictions and illiquidity generated by the forward-start American put option for 10 years results in an 18 percent discount.
Human activity recognition via motion and vision data fusion

Automated recognition of human daily activities is very important for human-robot interaction (HRI) in assisted living systems. We propose a Bayesian framework to integrate motion sensor observations and the location information from a vision system for human daily activity recognition. Two problems are studied in this paper: enhancing activity recognition through the fusion of two channels of information and learning the environment through the activity distribution map. The entropy associated with human activity recognition is adopted as an evaluation metric in both problems. The simulation results demonstrate the feasibility of the proposed methods.