Miracle-dz/UniFAR-FTUs huggingface dataset:
Plasma Levels of Soluble CD146 Reflect the Severity of Pulmonary Congestion Better Than Brain Natriuretic Peptide in Acute Coronary Syndrome

Background Acute heart failure negatively affects short-term outcomes of patients with acute coronary syndrome (ACS). Therefore, reliable and non-invasive assessment of pulmonary congestion is needed to select patients requiring more intensive monitoring and therapy. Since plasma levels of natriuretic peptides are influenced by myocardial ischemia, they might not reliably reflect congestion in the context of ACS. The novel endothelial biomarker, soluble CD146 (sCD146), presents discriminative power for detecting the cardiac origin of acute dyspnea similar to that of natriuretic peptides and is associated with systemic congestion. We evaluated the performance of sCD146 for the assessment of pulmonary congestion in the early phase of ACS. Methods One thousand twenty-one consecutive patients with ACS were prospectively enrolled. Plasma levels of sCD146, brain natriuretic peptide (BNP), and high-sensitive troponin T were measured within 24 hr after the onset of chest pain. Pulmonary congestion on chest radiography was determined and classified in three groups according to the degree of congestion. Results Nine hundred twenty-seven patients with ACS were analyzed. Ninety-two (10%) patients showed signs of pulmonary edema on chest radiography. Plasma levels of sCD146 reflected the radiological severity of pulmonary congestion. Higher plasma levels of sCD146 were associated with the worse degree of pulmonary congestion. In contrast to BNP, sCD146 levels were not affected by the level of troponin T. Conclusions The novel endothelial biomarker, sCD146, correlates with radiological severity of pulmonary congestion in the early phase of ACS and, in contrast to BNP, is not affected by the amount of myocardial cell necrosis.
Molecular Characterization of a Heteromeric ATP-Citrate Lyase That Generates Cytosolic Acetyl-Coenzyme A in Arabidopsis1,212

Acetyl-coenzyme A (CoA) is used in the cytosol of plant cells for the synthesis of a diverse set of phytochemicals including waxes, isoprenoids, stilbenes, and flavonoids. The source of cytosolic acetyl-CoA is unclear. We identified two Arabidopsis cDNAs that encode proteins similar to the amino and carboxy portions of human ATP-citrate lyase (ACL). Coexpression of these cDNAs in yeast (Saccharomyces cerevisiae) confers ACL activity, indicating that both the Arabidopsis genes are required for ACL activity. Arabidopsis ACL is a heteromeric enzyme composed of two distinct subunits, ACLA (45 kD) and ACLB (65 kD). The holoprotein has a molecular mass of 500 kD, which corresponds to a heterooctomer with an A4B4 configuration. ACL activity and the ACLA and ACLB polypeptides are located in the cytosol, consistent with the lack of targeting peptides in the ACLA and ACLB sequences. In the Arabidopsis genome, three genes encode for the ACLA subunit (ACLA-1, At1g10670; ACLA-2, At1g60810; and ACLA-3, At1g09430), and two genes encode the ACLB subunit (ACLB-1, At3g06650 and ACLB-2, At5g49460). The ACLA and ACLB mRNAs accumulate in coordinated spatial and temporal patterns during plant development. This complex accumulation pattern is consistent with the predicted physiological needs for cytosolic acetyl-CoA, and is closely coordinated with the accumulation pattern of cytosolic acetyl-CoA carboxylase, an enzyme using cytosolic acetyl-CoA as a substrate. Taken together, these results indicate that ACL, encoded by theACLA and ACLB genes of Arabidopsis, generates cytosolic acetyl-CoA. The heteromeric organization of this enzyme is common to green plants (including Chlorophyceae, Marchantimorpha, Bryopsida, Pinaceae, monocotyledons, and eudicots), species of fungi, Glaucophytes, Chlamydomonas, and prokaryotes. In contrast, all known animal ACL enzymes have a homomeric structure, indicating that a evolutionary fusion of theACLA and ACLB genes probably occurred early in the evolutionary history of this kingdom.
Directing the Development of Distinct Types of Brain Tumors from Postnatal Neural Stem / Progenitor Cells

Although brain tumors are classified and treated based upon their histology, the molecular factors involved in the development of various tumor types remain unknown. In this study, we show that the type and order of genetic events directs the development of gliomas, central nervous system primitive neuroectodermal tumors, and atypical teratoid/rhabdoid-like tumors from postnatal mouse neural stem/progenitor cells (NSC/NPC). We found that the overexpression of specific genes led to the development of these three different brain tumors from NSC/NPCs, and manipulation of the order of genetic events was able to convert one established tumor type into another. In addition, loss of the nuclear chromatin-remodeling factor SMARCB1 in rhabdoid tumors led to increased phosphorylation of eIF2a, a central cytoplasmic unfolded protein response (UPR) component, suggesting a role for the UPR in these tumors. Consistent with this, application of the proteasome inhibitor bortezomib led to an increase in apoptosis of human cells with reduced SMARCB1 levels. Taken together, our findings indicate that the order of genetic events determines the phenotypes of brain tumors derived from a common precursor cell pool, and suggest that the UPR may represent a therapeutic target in atypical teratoid/ rhabdoid tumors. Cancer Res; 72(13); 1–12. 2012 AACR.
8.1 nJ/b 2.4 GHz Short-Range Communication Receiver in 65 nm CMOS

An 8.1 nJ/bit 2.4 GHz receiver with integrated digital baseband supporting O-QPSK DSSS modulation compliant with the IEEE 802.15. 4 standard is presented that targets short-range, Internet of Things applications (IoTs). The sensitivity of a wireless communication receiver in general trades with power consumption. This receiver exploits this tradeoff to achieve a total power consumption of 2.02 mW including ADCs and digital baseband processing, at a sensitivity of -52.5 dBm at 250 Kbps. The energy-efficiency of the radio frequency (RF) front-end alone is nearly 2x better than the prior art. The receiver was fabricated in 65 nm CMOS with an area of 0.86 mm2.
Arylsulfatase B Improves Locomotor Function after Mouse Spinal Cord Injury

Bacterial chondroitinase ABC (ChaseABC) has been used to remove the inhibitory chondroitin sulfate chains from chondroitin sulfate proteoglycans to improve regeneration after rodent spinal cord injury. We hypothesized that the mammalian enzyme arylsulfatase B (ARSB) would also enhance recovery after mouse spinal cord injury. Application of the mammalian enzyme would be an attractive alternative to ChaseABC because of its more robust chemical stability and reduced immunogenicity. A one-time injection of human ARSB into injured mouse spinal cord eliminated immunoreactivity for chondroitin sulfates within five days, and up to 9 weeks after injury. After a moderate spinal cord injury, we observed improvements of locomotor recovery assessed by the Basso Mouse Scale (BMS) in ARSB treated mice, compared to the buffer-treated control group, at 6 weeks after injection. After a severe spinal cord injury, mice injected with equivalent units of ARSB or ChaseABC improved similarly and both groups achieved significantly more locomotor recovery than the buffer-treated control mice. Serotonin and tyrosine hydroxylase immunoreactive axons were more extensively present in mouse spinal cords treated with ARSB and ChaseABC, and the immunoreactive axons penetrated further beyond the injury site in ARSB or ChaseABC treated mice than in control mice. These results indicate that mammalian ARSB improves functional recovery after CNS injury. The structural/molecular mechanisms underlying the observed functional improvement remain to be elucidated.
Preamble design for channel estimation in MIMO-OFDM systems

A maximum-likelihood (ML) channel estimation and preamble design rules for the multiple-input-multiple-output (MIMO) channels are described when orthogonal frequency division multiplexing (OFDM) is employed with null subcarriers at both DC and high frequencies. The ML channel estimator in the time domain is derived assuming the knowledge of the maximum length of channel. To reduce the mean square error (MSE) of the estimation, three design rules are proposed: orthogonality between the preambles of different antennas, orthogonality between the circular shifted preamble sequences, and the condition that the number of subcarriers is larger than the maximum length of channel multiplied by the number of transmit antennas. In addition, we prove that the use of Golay complementary sequence (GCS) for preamble limits the peak to average power ratio (PAPR) by 3 dB although there are null subcarriers at high frequencies. Numerical results show that the MSE of the proposed method approaches that of optimum ML estimation when the number of null subcarriers and maximum length of channel are small.
A review of the AdS/CFT Duality

We give a review of conformal and superconformal symmetry. We introduce N = 4 Super Yang-Mills. We give a review of Type IIB Supergravity. We then state the correspondence between the two theories, and build a dictionary by matching symmetries, parameters and observables. We give some insight into further developments of the AdS/CFT correspondence
Let’s Chat about Brexit! A Politically-Sensitive Dialog System Based on Twitter Data

Data scientists are exploring various semi-supervised learning methods to build conversational agents - commonly known as chatterbot. This paper investigates various issues related to a political chatterbot where human agents are politically opinionated. Here, understanding the latent intent of human agent is crucial for developing an efficient political chatterbot. We set our study in the context of 2016 Brexit referendum. We argue that employing a subjectivity detector and an emotion analyzer, in addition to the keyword based topic detector, enhances the intent detection process. Next, we discuss the importance of maintaining political neutrality. To maintain its neutrality, a chatterbot needs to disassociate itself from a politically opinionated response. This can be achieved by associating a response with a user or a set of users. Nowadays, the Twitter platform provides an enormous amount of user-generated contents for various socio-economic events. Hence, we have considered tweet feeds for developing the overall chatterbot architecture in the political domain.
How to describe species richness patterns for bryophyte conservation?

Abstract A large amount of data for inconspicuous taxa is stored in natural history collections; however, this information is often neglected for biodiversity patterns studies. Here, we evaluate the performance of direct interpolation of museum collections data, equivalent to the traditional approach used in bryophyte conservation planning, and stacked species distribution models (S‐SDMs) to produce reliable reconstructions of species richness patterns, given that differences between these methods have been insufficiently evaluated for inconspicuous taxa. Our objective was to contrast if species distribution models produce better inferences of diversity richness than simply selecting areas with the higher species numbers. As model species, we selected Iberian species of the genus Grimmia (Bryophyta), and we used four well‐collected areas to compare and validate the following models: 1) four Maxent richness models, each generated without the data from one of the four areas, and a reference model created using all of the data and 2) four richness models obtained through direct spatial interpolation, each generated without the data from one area, and a reference model created with all of the data. The correlations between the partial and reference Maxent models were higher in all cases (0.45 to 0.99), whereas the correlations between the spatial interpolation models were negative and weak (−0.3 to −0.06). Our results demonstrate for the first time that S‐SDMs offer a useful tool for identifying detailed richness patterns for inconspicuous taxa such as bryophytes and improving incomplete distributions by assessing the potential richness of under‐surveyed areas, filling major gaps in the available data. In addition, the proposed strategy would enhance the value of the vast number of specimens housed in biological collections.
Tumor-Targeted Delivery of IL-2 by NKG2D Leads to Accumulation of Antigen-Specific CD8+ T Cells in the Tumor Loci and Enhanced Anti-Tumor Effects

Interleukin-2 (IL-2) has been shown to promote tumor-specific T-cell proliferation and differentiation but systemic administration of IL-2 results in significant toxicity. Therefore, a strategy that can specifically deliver IL-2 to the tumor location may alleviate concerns of toxicity. Because NKG2D ligands have been shown to be highly expressed in many cancer cells but not in healthy cells, we reason that a chimeric protein consisting of NKG2D linked to IL-2 will lead to the specific targeting of IL-2 to the tumor location. Therefore, we created chimeric proteins consisting of NKG2D linked to Gaussia luciferase (GLuc; a marker protein) or IL-2 to form NKG2D-Fc-GLuc and NKG2D-Fc-IL2, respectively. We demonstrated that NKG2D linked to GLuc was able to deliver GLuc to the tumor location in vivo. Furthermore, we showed that TC-1 tumor-bearing mice intramuscularly injected with DNA encoding NKG2D-Fc-IL2, followed by electroporation, exhibited an increased number of luciferase-expressing E7-specific CD8+ T cells at the tumor location. More importantly, treatment with the DNA construct encoding NKG2D-Fc-IL2 significantly enhanced the therapeutic anti-tumor effects generated by intradermal vaccination with therapeutic HPV DNA in tumor-bearing mice. Therefore, by linking NKG2D to IL2, we are able to specifically deliver IL-2 to the tumor location, enhancing antigen-specific T-cell immune response and controlling tumor growth. Our approach represents a platform technology to specifically deliver proteins of interest to tumor loci.
46.4: Self‐Aligned Bottom‐Gate Amorphous IGZO Thin Film Transistor using the Back Side Exposure Technique

In this work, we proposed new fabrication equipment for using the back side exposure technique in Gen.8 glass size and discussed a self‐alignment technique for fabrication of a‐IGZO TFTs which result in inverted staggered bottom gate devices, to simplify the OLED array processing. The Cgs of a‐IGZO TFTs with back side exposure process was lower about 40% than that of a a‐IGZO TFTs with typical process. The decrease in capacitance value of the back side exposure process a‐IGZO TFTs is because the overlap area between the gate and source/drain electrodes has become decrease. At Vds of 10V, the back side exposure process a‐IGZO TFTs represent μsat of 12.43 cm2/Vs, Vth of 0.75V, on‐current of 74.4uA, S‐Factor of 0.23V/dec.
A Rapid Method for Partial mRNA and DNA Sequence Analysis of the Photosystem II psbA Gene

Abstract Single amino acid substitutions in the D1 protein of photosystem II may cause resistance to various herbicides. In all organisms studied these substitutions are located in or between helices IV and V of the protein. The increasing number of herbicide-resistant organisms necessitates development of a rapid methodology to characterize deviations from the wildtype se quence. Here, two procedures are described to identify mutations in the psbA gene, which is coding for D1. These procedures involve the isolation and amplification of DNA and R A and subsequent sequencing reactions without the need to clone the psbA gene. A triazine-resistant and a -susceptible biotype of Chenopodium album were used as model species. An A to G transition, giving rise to a serine to glycine mutation at position 264 in the D1 protein, is found in the resistant plant.
Chip Self-Organization and Fault Tolerance in Massively Defective Multicore Arrays

We study chip self-organization and fault tolerance at the architectural level to improve dependable continuous operation of multicore arrays in massively defective nanotechnologies. Architectural self-organization results from the conjunction of self-diagnosis and self-disconnection mechanisms (to identify and isolate most permanently faulty or inaccessible cores and routers), plus self-discovery of routes to maintain the communication in the array. In the methodology presented in this work, chip self-diagnosis is performed in three steps, following an ascending order of complexity: interconnects are tested first, then routers through mutual test, and cores in the last step. The mutual testing of routers is especially important as faulty routers are disconnected by good ones with no assumption on the behavior of defective elements. Moreover, the disconnection of faulty routers is not physical (“hard”) but logical (“soft”) in that a good router simply stops communicating with any adjacent router diagnosed as defective. There is no physical reconfiguration in the chip and no need for spare elements. Ultimately, the multicore array may be viewed as a black box, which incorporates protection mechanisms and self-organizes, while the external control reduces to a simple chip validation test which, in the simplest cases, reduces to counting the number of valid and accessible cores.
Exploring Direct 3D Interaction for Full Horizontal Parallax Light Field Displays Using Leap Motion Controller

This paper reports on the design and evaluation of direct 3D gesture interaction with a full horizontal parallax light field display. A light field display defines a visual scene using directional light beams emitted from multiple light sources as if they are emitted from scene points. Each scene point is rendered individually resulting in more realistic and accurate 3D visualization compared to other 3D displaying technologies. We propose an interaction setup combining the visualization of objects within the Field Of View (FOV) of a light field display and their selection through freehand gesture tracked by the Leap Motion Controller. The accuracy and usefulness of the proposed interaction setup was also evaluated in a user study with test subjects. The results of the study revealed high user preference for free hand interaction with light field display as well as relatively low cognitive demand of this technique. Further, our results also revealed some limitations and adjustments of the proposed setup to be addressed in future work.
Local Learning to Improve Organizational Performance in Networked Multiagent Team Formation

Networked multiagent systems are comprised of many autonomous yet interdependent agents situated in a virtual social network. Two examples of such systems are supply chain networks and sensor networks. A common challenge in many networked multiagent systems is decentralized team formation among the spatially and logically extended agents. Even in cooperative multiagent systems, efficient team formation is made difficult by the limited local information available to the individual agents. We present a model of distributed multiagent team formation in networked multi-agent systems, describe a policy learning framework for joining teams based on local information, and give empirical results on improving team formation performance. In particular, we show that local policy learning from limited information leads to a significant increase in organizational team formation performance compared to a naive heuristic.
Hormesis and Paradoxical Effects of Drooping Birch (Betula pendula Roth) Parameters Under Motor Traffic Pollution

Various plant indexes are used or recommended for bioindication. However, the nonmonotonic dose–response dependences (hormesis and paradoxical effects) of these indexes are insufficiently explored upon exposure to pollution. We studied the dependences of these Betula pendula indexes on the intensity of motor traffic pollution. Regression analysis did not reveal any dependence of chlorophyll and carotenoid content on traffic intensity (in 2008 and 2010-2013). Lipid peroxidation rate had different versions of paradoxical effects in 2008 and 2010 to 2012 and increased in comparison with control under an increase in pollution level in 2013. In 2010 to 2012, all dose–response dependences for total protein and thiol group content were biphasic and multiphasic paradoxical effects. In 2013, an increase in traffic intensity induced a linear reduction in protein content and an increase in thiol group level in comparison with the control. In most cases, the studied phenological indexes and seed production decreased monotonically in comparison with the control following an increase in traffic intensity. Only in 2010 and 2013, share of fallen leaves had hormesis and paradoxical effect accordingly. Fluctuating asymmetry had a paradoxical effect and hormesis in 2008 and 2012, accordingly, and increased in comparison with the control under an increase in the level of pollution in 2010 to 2011.
Diagnostic utility of facet (zygapophysial) joint injections in chronic spinal pain: a systematic review of evidence.

BACKGROUND Chronic refractory spinal pain poses a peculiar diagnostic challenge because of multiple putative pain sources, overlapping clinical features, and nonspecific radiologic findings. Diagnostic injection techniques are employed to isolate the source(s) of pain. Facet or zygapophysial joint pain is an example of spinal pain diagnosed by local anesthetic injections of the facet joint or its nerve supply. Diagnostic facet joint injections are expected to meet the cardinal features of a diagnostic test (i.e., accuracy, safety and reproducibility). Accuracy must be compared with a "gold" or criterion standard that can confirm presence or absence of a disease. There is, however, no available gold standard, such as biopsy, to measure presence or absence of pain. Hence, there is a degree of uncertainty concerning the accuracy of diagnostic facet joint injections. OBJECTIVES To evaluate accuracy, safety and reproducibility of facet or zygapophysial joint injections in diagnosing chronic spinal pain of facet joint origin. STUDY DESIGN A systematic review of the literature for clinical studies on efficacy and utility of facet joint/nerve injections in diagnosing spinal pain from facet joints. METHODS Relevant literature on diagnostic facet injections was identified through database searches. Excluded were abstracts, reviews, book chapters, case reports and studies based on single blocks or blocks without radiologic control. Prospective studies with placebo control, or controlled comparative local anesthetic blocks, were given priority over retrospective studies. Each study was graded using AHRQ and QUADAS criteria. The level of evidence was classified as conclusive, strong, moderate, limited, or inconclusive. RESULTS Available literature pointed to strong evidence for controlled comparative local anesthetic facet joint medial branch blocks in the diagnosis of neck and low back pain. There was moderate evidence in the diagnosis of pain arising from thoracic facet joints. CONCLUSION The evidence obtained from literature review suggests that controlled comparative local anesthetic blocks of facet joint nerves (medial branch or dorsal ramus) are reproducible, reasonably accurate, and safe. The sensitivity, specificity, false-positive rates, and predictive values of these diagnostic tests for neck and low back pain have been validated and reproduced in multiple studies.