Miracle-dz/UniFAR-FTUs huggingface dataset:
Conservation of G-Protein Epitopes in Respiratory Syncytial Virus (Group A) Despite Broad Genetic Diversity: Is Antibody Selection Involved in Virus Evolution?

ABSTRACT Worldwide G-glycoprotein phylogeny of human respiratory syncytial virus (hRSV) group A sequences revealed diversification in major clades and genotypes over more than 50 years of recorded history. Multiple genotypes cocirculated during prolonged periods of time, but recent dominance of the GA2 genotype was noticed in several studies, and it is highlighted here with sequences from viruses circulating recently in Spain and Panama. Reactivity of group A viruses with monoclonal antibodies (MAbs) that recognize strain-variable epitopes of the G glycoprotein failed to correlate genotype diversification with antibody reactivity. Additionally, no clear correlation was found between changes in strain-variable epitopes and predicted sites of positive selection, despite both traits being associated with the C-terminal third of the G glycoprotein. Hence, our data do not lend support to the proposed antibody-driven selection of variants as a major determinant of hRSV evolution. Other alternative mechanisms are considered to account for the high degree of hRSV G-protein variability. IMPORTANCE An unusual characteristic of the G glycoprotein of human respiratory syncytial virus (hRSV) is the accumulation of nonsynonymous (N) changes at higher rates than synonymous (S) changes, reaching dN/dS values at certain sites predictive of positive selection. Since these sites cluster preferentially in the C-terminal third of the G protein, like certain epitopes recognized by murine antibodies, it was proposed that immune (antibody) selection might be driving the apparent positive selection, analogous to the antigenic drift observed in the influenza virus hemagglutinin (HA). However, careful antigenic and genetic comparison of the G glycoprotein does not provide evidence of antigenic drift in the G molecule, in agreement with recently published data which did not indicate antigenic drift in the G protein with human sera. Alternative explanations to the immune-driven selection hypothesis are offered to account for the high level of G-protein genetic diversity highlighted in this study.
Evolutionary Generation of Subwavelength Planar Element Loaded Monopole Antenna

A very compact monopole antenna with an evolutionarily generated subwavelength planar element is proposed for the antenna miniaturization without using any lumped capacitors and inductors. The monopole antenna is composed of a coaxial-fed short line etched on one side of dielectric substrate and a subwavelength element on the other side, enabling an easy fabrication using a printed circuit technology. To design the arbitrarily shaped subwavelength element, an efficient genetic algorithm (GA) design technique is employed. As a design example, a monopole antenna with 1/23-wavelength height and 1/17-wavelength width at 430 MHz is demonstrated. The predicted results of the radiation pattern and the reflection characteristic are compared to measured data, and good agreement between the two results is achieved.
Absence of the KhpA and KhpB (JAG/EloR) RNA‐binding proteins suppresses the requirement for PBP2b by overproduction of FtsA in Streptococcus pneumoniae D39

Suppressor mutations were isolated that obviate the requirement for essential PBP2b in peripheral elongation of peptidoglycan from the midcells of dividing Streptococcus pneumoniae D39 background cells. One suppressor was in a gene encoding a single KH‐domain protein (KhpA). ΔkhpA suppresses deletions in most, but not all (mltG), genes involved in peripheral PG synthesis and in the gpsB regulatory gene. ΔkhpA mutations reduce growth rate, decrease cell size, minimally affect shape and induce expression of the WalRK cell‐wall stress regulon. Reciprocal co‐immunoprecipitations show that KhpA forms a complex in cells with another KH‐domain protein (KhpB/JAG/EloR). ΔkhpA and ΔkhpB mutants phenocopy each other exactly, consistent with a direct interaction. RNA‐immunoprecipitation showed that KhpA/KhpB bind an overlapping set of RNAs in cells. Phosphorylation of KhpB reported previously does not affect KhpB function in the D39 progenitor background. A chromosome duplication implicated FtsA overproduction in Δpbp2b suppression. We show that cellular FtsA concentration is negatively regulated by KhpA/B at the post‐transcriptional level and that FtsA overproduction is necessary and sufficient for suppression of Δpbp2b. However, increased FtsA only partially accounts for the phenotypes of ΔkhpA mutants. Together, these results suggest that multimeric KhpA/B may function as a pleiotropic RNA chaperone controlling pneumococcal cell division.
Legal content fusion for legal information retrieval

With recent increasing attention to legal information processing, legal information retrieval (IR) has become one of the active research fields. However, there are still many hindrances obtaining rigorous results in legal IR applications in comparison with IR applications for general document retrieval. It is mainly due to the characteristics of legal information such as the complicated structure of legal contents and usage of legal jargon. In this paper, we present a legal IR method, which is a structure-wise IR approach. e presented method in this study focuses on analyzing the contents of legal documents and applying the content contributions to the IR processing. We demonstrate the performance of the proposed IR method with the COILEE data set, which are derived from Japanese bar exams.
A 3D STOKES FRAMEWORK FOR WIRELESS DEPOLARIZED CHANNELS

In severe multipath channels, depolarization of wireless signals has been shown to be a three dimensional effect. This work herein presents and applies a 3D Stokes vector framework for such depolarization. Empirical data are used to illustrate the capabilities of this framework (specifically, polarization purity indices and direction of propagation) to describe depolarization behavior for three different wireless channels.
Representing Australia

Sport and representations of sport in the media are key sites for political and social struggles around race and nation. In order to explore how meanings of race are constructed in a sporting context, we undertook a discourse analysis of Australian print media coverage of two incidents of alleged racial vilification in sport. In one, Australian cricketer Darren Lehmann was suspended for racially vilifying the Sri Lankan team. In the other, Pakistani cricketer Rashid Latif was accused of racially vilifying an Australian cricketer. Our research suggests the following: first, there was strong condemnation of racial vilification; second, despite this, print media representations reflect a white versus black divide in world cricket; third, a Lehmann as victim/reverse racism theme emerged. We conclude that race is being mobilized as a potent but contested symbol of both inclusion and exclusion within Australia.
Sensitivity of a Salmonella typhimurium aspC mutant to sulfometuron methyl, a potent inhibitor of acetolactate synthase II

Sulfometuron methyl is a potent and specific inhibitor of acetolactate synthase II in Salmonella typhimurium. Mutant strains sensitive to sulfometuron methyl on minimal medium were isolated following mutagenesis with Tn10. A conditionally auxotrophic insertion mutant, strain SMS409, which required aspartate at high temperatures or in the presence of tyrosine, was found among the 15 mutants isolated. The Tn10 insertion in strain SMS409 was mapped by conjugation and transduction to the region between aroA and pncB at 20 min on the chromosome of S. typhimurium; this location is similar to the genetic location of aspC in Escherichia coli. The specific activity of the aspC product, aspartate aminotransferase, was severely reduced in strain SMS409. This indicated that the Tn10 insertion in strain SMS409 inactivated aspC. An aspC mutant of E. coli was also inhibited by either sulfometuron methyl or tyrosine. We present a hypothesis which relates the observed alpha-ketobutyrate accumulation in sulfometuron methyl-inhibited cultures of strain SMS409 to aspartate starvation.
Effect of the ethanol extract of Pleurotus eryngii on bone metabolism in ovariectomized rats

Abstract Objective Postmenopausal bone loss and the possible progression to osteoporosis are a major health concern. Mushrooms have been recognized as functional foods. Pleurotus eryngii extract has been reported to have estrogenic activity, suggesting that its consumption may mitigate postmenopausal bone loss. The aim of the present study was to determine the effect of supplementation with an ethanol extract of P. eryngii on bone metabolism in a postmenopausal osteoporosis rat model. Methods Female 12-week-old Wistar rats were subjected to either sham operation or bilateral ovariectomy. The ovariectomized rats were then subdivided into two groups: one fed the extract and the other not. Twelve weeks after surgery, indices of bone mass, bone histomorphometry, and bone mechanics were measured. Results The right femur bone mineral content and density of the ovariectomized group were significantly lower than in the Sham group, and extract supplementation did not have any significant effect on these differences. Furthermore, ovariectomy significantly increased measures of mineralizing surface and bone formation rates; again, extract supplementation again had no significant effect. Conclusion Our findings suggest that the ethanol extract of P. eryngii does not alter bone metabolism in ovariectomized rats, suggesting that consumption of P. eryngii may not be beneficial in slowing bone loss after menopause.
Training of affect recognition in schizophrenia patients with violent offences: Behavioral treatment effects and electrophysiological correlates

Violent offenders with schizophrenia have a particularly poor performance level in facial affect recognition. Nineteen male schizophrenia patients, who had been committed to psychiatric hospital detention because of violent offences and lack of criminal responsibility, were recruited to receive the Training of Affect Recognition (TAR). Performance in the Pictures of Facial Affect (PFA)-test and event-related potentials (ERPs) were registered in a pre–post-treatment design. TAR was feasible with a very high treatment effect (Cohen’s d = 1.88), which persisted for 2 months post-treatment. ERPs remained unchanged post- vs. pre-treatment, while low resolution brain electromagnetic tomography (LORETA) revealed activation decreases in left-hemispheric parietal–temporal–occipital regions at 172 msec and activation increases in right dorsolateral prefrontal cortex and anterior cingulate at 250 msec. Possibly, violent offenders with schizophrenia are particularly amenable to TAR because of a high level of dysfunction at baseline. Post- vs. pre-treatment changes of neural activity (LORETA) may mirror a gain of efficiency in structural face decoding and a shift towards a more reflective mode of emotional face decoding, relying on increased frontal brain activity. Functional magnetic resonance imaging (BOLD-fMRI) -data from another study further supports this notion. TAR treatment might enable subjects with schizophrenia and a disposition to violence to reach a higher degree of deliberation of their reactive behavior to facial affect stimuli.
The ʽDiverse Economies’ of Participation

This article begins to construct a theory of participation in architecture, urban design and urban planning as a range of practices undertaken across a landscape of economies that largely exists outside of the capitalist economy. These practices themselves overlap in terms of their material forms, bodily and mental activities with the practices undertaken by labour employed to produce the built environment within the capitalist marketplace. With respect to participation, our aim in articulating practices is to move away from a discussion of levels of participation and legitimacy within individual projects and towards an understanding of the organising, productive and reproductive work that is done in participating in the production of the built environment as part of an ongoing process of social change. They proliferate through multiple instances of performance and those who undertake them act as carriers of these practices, including forms of knowhow, understanding, motivational and emotional knowledge, creating resources through these acts of performance. The article contends that participatory practices are liable to be exploited re-presented or co-opted as commodified resources and this fragility limits the socially transformative potential of participation. Drawing on J.K Gibson-Graham’s conception of ‘diverse economies’, an alternative representation is developed to recognize the landscape of practices constructing alternative economic systems, and exploring means and methods of resistance to co-option or enclosure.
Overcoming the limitations of living donor and split liver transplantation: A proposal for adult recipients (the best of the east in the west)

A shortage of organs for liver transplantation has encouraged the development of advanced surgical strategies to increase the donor pool. We present a technical strategy that combines the established techniques of split liver transplantation and left lateral segment donation from living donors for adult recipients. This strategy could provide an additional source of organs for liver transplantation. Liver Transpl 14:932–934, 2008. © 2008 AASLD.
The Transcriptional Antiterminator RfaH Represses Biofilm Formation in Escherichia coli

ABSTRACT We investigated the influence of regulatory and pathogenicity island-associated factors (Hha, RpoS, LuxS, EvgA, RfaH, and tRNA5Leu) on biofilm formation by uropathogenic Escherichia coli (UPEC) strain 536. Only inactivation of rfaH, which encodes a transcriptional antiterminator, resulted in increased initial adhesion and biofilm formation by E. coli 536. rfaH inactivation in nonpathogenic E. coli K-12 isolate MG1655 resulted in the same phenotype. Transcriptome analysis of wild-type strain 536 and an rfaH mutant of this strain revealed that deletion of rfaH correlated with increased expression of flu orthologs. flu encodes antigen 43 (Ag43), which mediates autoaggregation and biofilm formation. We confirmed that deletion of rfaH leads to increased levels of flu and flu-like transcripts in E. coli K-12 and UPEC. Supporting the hypothesis that RfaH represses biofilm formation through reduction of the Ag43 level, the increased-biofilm phenotype of E. coli MG1655rfaH was reversed upon inactivation of flu. Deletion of the two flu orthologs, however, did not modify the behavior of mutant 536rfaH. Our results demonstrate that the strong initial adhesion and biofilm formation capacities of strain MG1655rfaH are mediated by both increased steady-state production of Ag43 and likely increased Ag43 presentation due to null rfaH-dependent lipopolysaccharide depletion. Although the roles of rfaH in the biofilm phenotype are different in UPEC strain 536 and K-12 strain MG1655, this study shows that RfaH, in addition to affecting the expression of bacterial virulence factors, also negatively controls expression and surface presentation of Ag43 and possibly another Ag43-independent factor(s) that mediates cell-cell interactions and biofilm formation.
Progressive compression of arbitrary textured meshes

In this paper, we present a progressive compression algorithm for textured surface meshes, which is able to handle polygonal non‐manifold meshes as well as discontinuities in the texture mapping. Our method applies iterative batched simplifications, which create high quality levels of detail by preserving both the geometry and the texture mapping. The main features of our algorithm are (1) generic edge collapse and vertex split operators suited for polygonal non‐manifold meshes with arbitrary texture seam configurations, and (2) novel geometry‐driven prediction schemes and entropy reduction techniques for efficient encoding of connectivity and texture mapping. To our knowledge, our method is the first progressive algorithm to handle polygonal non‐manifold models. For geometry and connectivity encoding of triangular manifolds and non‐manifolds, our method is competitive with state‐of‐the‐art and even better at low/medium bitrates. Moreover, our method allows progressive encoding of texture coordinates with texture seams; it outperforms state‐of‐the‐art approaches for texture coordinate encoding. We also present a bit‐allocation framework which multiplexes mesh and texture refinement data using a perceptually‐based image metric, in order to optimize the quality of levels of detail.
Clinical Factors Influencing the Absorption of 125I-NPH Insulin in Diabetic Patients

Clinical factors which might influence the absorption of subcutaneously injected 125I-NPH insulin were studied in 101 diabetics. The disappearance curve was monoexponential after a delay period of 1.5 +/- 0.8 h (mean +/- SD). Lipohypertrophy significantly prolonged insulin absorption (half life (T1/2) = 11.2 +/- 3.1 h, p = 0.0001). Low bicarbonate levels increased the absorption (T1/2 3.9 +/- 2.3 h, p less than 0.05). Lean diabetics had a faster absorption (6.2 +/- 1.9 h) than normal weight diabetics (7.5 +/- 2.0 h, p less than 0.02). Sex, age, diabetes duration and injection depth did not influence T1/2. The half life was significantly inversely correlated to the resting subcutaneous blood flow (r = 0.882, p less than 0.01). The overall interindividual coefficient of variation for insulin absorption in nonketotic diabetics was 27.4%. Also considerable intra-patient day-to-day variation was found (24.5%), and between different injection sites (30.2%). These variations emphasize the drawbacks of conventional insulin therapy in the management of insulin-requiring diabetics.
Accurate alpha soft error rate evaluation in SRAM memories

Radiation sensitivity of SRAM memories is of vital importance in applications demanding high reliability levels. Soft error rates (SER) are usually determined through accelerated tests where target devices are subjected to very high levels of radiation, in order to increase the number of induced events. Two main factors determine the accuracy of this technique, on one hand, when the number of induced events is low the result is subjected to statistical errors, on the other hand, if the number of induced events is high, the probability that each cell experiences more than one event is increased, as a result there is the risk that a fraction of the events will not be counted. In this paper we propose an accelerated test method to determine the soft error rate in SRAM memories from a model based on the evolution of the cell population being at logic zero (or logic one) during the irradiation experiment. This model has been contrasted with experimental results obtaining a very good correlation.
The Effect of Pharmaceutical Innovation on the Functional Limitations of Elderly Americans Evidence from the 2004 National Nursing Home Survey

PURPOSE To examine the effect of pharmaceutical innovation on the functional status of nursing home residents. METHODOLOGY/APPROACH Estimation of econometric models of the ability of nursing home residents to perform activities of daily living (ADLs) using cross-sectional, patient-level data from the 2004 National Nursing Home Survey. The explanatory variables of primary interest are the characteristics (e.g., the mean vintage (FDA approval year)) of the medications used by the resident. We control for age, sex, race, marital status, veteran status, where the resident lived prior to admission, primary diagnosis at the time of admission, up to 16 diagnoses at the time of the interview, sources of payment, and facility fixed effects. FINDINGS The ability of nursing home residents to perform ADLs is positively related to the number of "new" (post-1990) medications they consume, but unrelated to the number of old medications they consume. I estimate that if 2004 nursing home residents had used only old medications, the fraction of residents with all five ADL dependencies (number of activities for which the resident is not independent) would have been 58% instead of 50%. SOCIAL IMPLICATIONS During 1990-2004, pharmaceutical innovation for reduced the functional limitations of nursing home residents by between and 1.2% and 2.1% per year. ORIGINALITY/VALUE OF CHAPTER The first public-use survey of nursing homes that contains detailed information about medication use, and better data on functional status than previous surveys, is used to help explain why there has been a significant decline in the functional limitations of older people.
The unintended consequences of the debt: Will increased government expenditure hurt the economy?

In 2008, governments in many countries embarked on large fiscal expenditure programmes, with the intention to support the economy and prevent a more serious recession. In this study, the overall impact of a substantial increase in fiscal expenditure is considered by providing a novel analysis of the most relevant recent experience in similar circumstances, namely that of Japan in the 1990s. Then a weak economy with risk-averse banks seemed to require some of the largest peacetime fiscal stimulation programmes on record, albeit with disappointing results. The explanations provided by the literature and their unsatisfactory empirical record are reviewed. An alternative explanation, derived from early Keynesian models on the ineffectiveness of fiscal policy is presented in the form of a modified Fisher-equation, which incorporates the recent findings in the credit view literature. The model postulates complete quantity crowding out. It is subjected to empirical tests, which were supportive. Thus evidence is found that fiscal policy, if not supported by suitable monetary policy, is likely to crowd out private sector demand, even in an environment of falling or near-zero interest rates. As a policy conclusion it is pointed out that by changing the funding strategy, complete crowding out can be avoided and a positive net effect produced. The proposed framework creates common ground between proponents of Keynesian views (as held, among others, by Blinder and Solow), monetarist views (as held in particular by Milton Friedman) and those of leading contemporary macroeconomists (such as Mankiw).
Treatment of recurrent lingual nerve end‐neuroma: A case report

A neuroma is a collection of disorganized nerve sprouts emanating from an interruption of axonal continuity, forming within a collagen scar as the nerve attempts to regenerate. Lingual neuroma formation secondary to iatrogenic trauma to the tongue is likely not uncommon; however, we could not find a report in the literature of treatment of a distal tongue end‐neuroma treated by resection and implantation into muscle. Here we describe a patient who experienced debilitating chronic tongue pain after excision of a benign mass. After failing conservative management, the patient was taken to the operating room where an end‐neuroma of the lingual nerve was identified and successfully treated by excision and burying of the free proximal stump in the mylohyoid muscle. At 17 months postoperatively, she remains pain free without dysesthesias. © 2013 Wiley Periodicals, Inc. Microsurgery 33:575–577, 2013.