Miracle-dz/UniFAR-FTUs huggingface dataset:
Branchial cyst and cervical cystic metastases

Dear Sir, Peltola and Saarento (1992) in their Short Communication propose a 'new method' to visualize foreign bodies hidden in the anterior tympanomeatal angle by administering water in the ear canal of the patient (who should lie on his back with his head tilted). While I agree that this trick does work I came up with a different explanation of how the water might assist in visualizing this commonly invisible area (Wind, 1984). I assumed and still assume that the water surface adopts a convex position rather than a concave one as Peltola and Saarento think. Also I mentioned that the oblique position of the surface relative to the optical axis of the microscope adds to the desired effect by obtaining refraction (cf. the oblique-stick-in-thewater effect). While it might be worthwhile to conduct some experiments to assess the (positive or negative) relative contributions of both mechanisms to the effect concerned, I do not believe that simply washing out the ear wax, as suggested by the authors, suffices to remove all the wax from the ear canal skin and so obtain the water surface adopting a concave shape. Yours faithfully, Professor Jan Wind, Gooi-Noord Hospital, P.O. Box 900, 1250CALaren, Netherlands. excise the cystic mass in the neck for histological examination with a comprehensive head and neck examination. Cervical cystic metastases may indeed be misdiagnosed as a branchial cyst by the unwary because of its location, but it should not be forgotten that the only absolute proof of the nature of any cystic mass is its histological examination. The difficulty, however, would arise only if two conditions combine—first, an occult primary and second, a cystic degeneration in a metastatic node. This may suggest a tumour arising in a pre-existing branchial cyst (malignant branchioma). It is certain that the great majority of these tumours so-designated are metastases from a primary growth elsewhere (Willis, 1960). In such cases we feel that it is illogical to subject patients to ipsilateral tonsillectomy for the following—firstly, the source of occult primary can be anywhere in the different parts of Waldeyer's ring (Micheau et al., 1990) and secondly tonsillectomy may not contribute too much to the whole outcome if these patients are treated as we advocate in a report to be published soon with a prophylactic radical course of radiotherapy to the whole region of Waldeyer's ring, in addition to removal of the cystic mass (El-Sharkawi and Williams, 1992). Yours faithfully,
Mean analgesic consumption is inappropriate for testing analgesic efficacy in post-operative pain: analysis and alternative suggestion

Background and objective Post-operative analgesic consumption is often used as a surrogate measure for pain; analyses of mean data assume a Gaussian distribution and use parametric statistics to assess statistical differences, often in small samples. We used a large individual patient dataset to examine the distribution of analgesic consumption, the validity of such analyses and alternative dichotomous outcomes. Methods Analysis of individual patient data from 913 patients over 48 post-operative hours in five randomised trials. Patients had either epidural injection of placebo or morphine (as sulphate and extended release epidural morphine) and use of patient-controlled analgesia. Post-operative fentanyl consumption was calculated over 0–24, 24–48 and 0–48 h. Results The distribution of analgesic consumption for all patients over the periods 0–24, 24–48 and 0–48 h was exponential. Most patients used less than 750 μg fentanyl over 48 h; 34% used over 1000 μg fentanyl (100 mg morphine), 13% over 2000 μg and 5% over 3000 μg. Mean, median and mode were very different; 20% of patients consumed almost 60% of post-operative analgesic, and standard deviations were generally larger than means. A useful dichotomous outcome was less than 750 μg fentanyl consumed over 48 h, a level associated with very good or excellent patient pain rating. Use of very good or excellent patient pain rating differentiated between different doses of epidural morphine. Conclusion Because of a highly skewed distribution, post-operative analgesic consumption is an uncertain method of measuring analgesic efficacy of an intervention designed to limit pain during and after surgery.
CORF: Collective Educational Research Facility - Design of a Platform Supporting Educational Research as an Integral Joint Effort of Researchers and Teaching Professionals

In educational research, like in other research fields, there is a growing call for sharing data and results. The public interest in results is clear, and much of the research is done using public money. Besides this, educational research a gap exists between the research community and research outcomes on one hand, and secondary school teachers, schools and educational practice on the other. CORF® (in English: Collective Educational Research Facility) is a web-based platform that supports the sharing of research instruments and research data within and across research projects. CORF® community members may be professional researchers as well as educational practitioners. In this contribution, the concept of CORF® is presented and its major design characteristics are outlined. The system was realized as an internet platform and employed by various researchers, teachers, and student teachers. A general evaluation and three use-cases are presented leading to conclusions on the strength and weaknesses of the platform and conditions for adequate
Chebyshev transfer functions for the synthesis of an ultra-wideband(UWB) filter using short-circuit stub resonator

In this paper, the Chebyshev transfer functions is proposed to synthesis and design a UWB filter using short-circuited stub resonator. A half wavelength transmission line with an embedded quarter wavelength short-circuited stub can be seen as a multi-modes resonator (MMR) to achieve a wide bandwidth, moreover, the embedded short-circuited stub can produce a pair of transmission zero to achieve a sharper rejection skirt. A UWB filter using short-circuited stub resonator is synthesized and simulated, the electromagnetic (EM) simulation results and the circuit simulation through the synthesis theory are almost the same.
An Environmental Scan for Early Mobilization Practices in U.S. ICUs

Objective: Early mobilization improves patient outcomes. However, diffusion of this intervention into standard ICU practice is unknown. Dissemination and implementation efforts may be guided by an environmental scan to detail readiness for early mobilization, current practice, and barriers to early mobilization. Design: A telephone survey. Setting: U.S. ICUs. Subjects: Five hundred randomly selected U.S. ICUs stratified by regional hospital density and hospital size. Interventions: None. Measurements and Main Results: We surveyed 687 ICUs for a 73% response rate (500 ICUs); 99% of respondents were nursing leadership. Fifty-one percent of hospitals reported an academic affiliation. Surveyed ICUs were most often mixed medical/surgical (58%) or medical (22%) with a median of 16 beds (12–24). Thirty-four percent reported presence of a dedicated physical and/or occupational therapy team for the ICU. Overall, 45% of ICUs reported early mobilization practice; two thirds of ICUs with early mobilization practice reported using a written early mobilization protocol. In ICUs with early mobilization practice, 52% began the intervention at admission and 74% enacted early mobilization for both ventilated and nonventilated patients. Early mobilization was provided a median of 6 days per week, twice daily. Factors independently associated with early mobilization protocols include dedicated physical/occupational therapy (odds ratio, 3.34; 95% CI, 2.13–5.22; p < 0.01), American Hospital Association region 2 (odds ratio, 3.33; 95% CI, 1.04–10.64; p = 0.04), written sedation protocol (odds ratio, 2.36; 95% CI, 1.25–4.45; p < 0.01), daily multidisciplinary rounds (odds ratio, 2.31; 95% CI, 1.29–4.15; p < 0.01), and written daily goals for patients (odds ratio, 2.17; 95% CI, 1.02–4.64; p = 0.04). Commonly cited barriers included equipment, staffing, patient and caregiver safety, and competing priorities. In ICUs without early mobilization adoption, 78% have considered implementation but cite barriers including competing priorities and need for further planning. Conclusions: Diffusion regarding benefits of early mobilization has occurred, but adoption into practice is lagging. Mandates for multidisciplinary rounds and formal sedation protocols may be necessary strategies to increase the likelihood of successful early mobilization implementation. Methods to accurately assess and compare institutional performance via practice audit are needed.
Wearable Disc-Like Antenna for Body-Centric Communications at 61 GHz

In this letter, we describe the design and simulation of on-body antennas for wireless body area network (WBAN) communication operating in the 61-GHz ISM frequency band. We developed a disc-like concept of an antenna. Instead of a direct connection between a circular disc and a feeding pin, the electromagnetic coupling is used. This concept enables us to obtain relatively broadband characteristics with omnidirectional radiation pattern and vertical polarization suitable for on-body communication. Impedance properties and radiation of the antenna were studied in open space and on a tissue-equivalent phantom representing the human body. Fabricated prototype is well matched from 59.3 to 63.4 GHz. The bandwidth of the antenna is about 7%. An antenna analyzed close to body tissue exhibits efficiency of at least 25% and the maximum gain 5.2 dB in the horizontal plane.
Parallel episodes of phyletic dwarfism in callitrichid and cheirogaleid primates

The Callitrichidae are the smallest anthropoids, whereas the Cheirogaleidae include the smallest of all primates. Using species‐level analyses, we show that these are derived conditions; both neonatal and adult body mass decreased in a gradual, phyletic manner in parallel across callitrichids, and across cheirogaleids. We identify lineages with particularly rapid decreases and highlight the pygmy marmoset, Callithrix pygmaea, as a phenotypic outlier. The life‐history traits associated with body‐mass reduction in each clade suggest that the convergent evolution of small body size was achieved by changes in different ontogenetic stages. Body‐size reduction in callitrichids appears to be almost exclusively due to alterations in prenatal growth rate, whereas body‐size reduction in cheirogaleids may have been largely due to reduced duration of growth phases. Finally, we use these results to discuss some of the debates surrounding the evolution of Homo floresiensis and suggest potential parallels between the evolution of H. floresiensis and callitrichids.
Silicon Heterojunction Solar Cells With Copper-Plated Grid Electrodes: Status and Comparison With Silver Thick-Film Techniques

Copper electroplating is investigated and compared with common silver printing techniques for the front metallization of silicon heterojunction solar cells. We achieve smaller feature sizes by electroplating, significantly reducing optical shadowing losses and improving cell efficiency by 0.4% absolute. A detailed investigation of series resistance contributions reveals that, at maximum power point, a significant part of the lateral charge-carrier transport occurs inside the crystalline bulk, rather than exclusively in the front transparent conductive oxide. This impacts optimization for the front-grid design. Using advanced electron microscopy, we study the inner structure of copper-plated fingers and their interfaces. Finally, a cell efficiency of 22.4% is demonstrated with copper-plated front metallization.
Molecular Dynamics Simulation Study of the Interaction of Piscidin 1 with DPPC Bilayers: Structure-Activity Relationship

Abstract To study structure-activity relationship of antimicrobial peptides and to design novel antimicrobial peptides with selectivity for bacterial cells, we have performed molecular dynamics simulations of the interaction of Piscidin (Pis1) and its two analogues (Pis1-AA and Pis1-PG) with dipalmitoylphosphatidylcholine (DPPC) bilayer through 45 ns. Our results inform us of the detailed location and orientation of the peptide with respect to the bilayer as well as provide about hydrogen-bond-formation patterns and electrostatics interactions. Simulations show that Pis1 and Pis-AA form the most hydrogen bonds and Pis-PG forms the fewest hydrogen bonds with lipid. Thus, Pis1 and Pis-AA should have stronger interactions with the lipid head group when compared to Pis-PG. Experimental studies have shown that Pis1 and Pis1-AA have a high antimicrobial and hemolytic activities, and Pis1-PG has low hemolytic activity while keeps potent antimicrobial activity. Our results complement the previous experimental studies. According to our MD results and previous experimental studies, Pis1 and Pis1-AA are more effective at the zwitterionic bilayer comparing Pis1-PG. These properties of Pis1-PG could be accordance with its low hemolytic activities.
An Interface for Assisted Curation of Knowledge Bases from Unstructured Text

We present an interactive graphical tool for assisted curation of knowledge bases from unstructured text data. Given text input, the user can create a knowledge base from scratch, including sub-tasks of entity mention annotation, matching mentions that refer to the same entity, and extracting relations between entities. The interface is designed to enable organizations to extract valuable knowledge from text data that may otherwise remain unexploited. We evaluate the interface through a formative user study. The study results suggest several key directions for refinement. Results also highlight the efficacy of the interface: all participants were able to create a knowledge base from scratch.
Studies of the microcirculation using transparent tissue observation chambers inserted in the hamster cheek pouch.

The ideal preparation for the study of the microcirculation must possess anatomical and physiological normality, at least during the initial stages of observations. It should be thin enough to enable the use of high powers of magnification where transmitted or reflected light is required. Repeated observations must be possible, preferably without anaesthesia. In some instances, direct accessibility to the preparation for biopsy may also be required. Whatever the method, minimal surgical interference is desirable to ensure preservation of the environment. None of the methods currently used satisfy all these criteria and the choice of the method will be determined by the most critical factor in the problem under investigation. The limitations of the chosen technique will have to be accepted, unless another method is used concurrently to overcome certain disadvantages peculiar to the first-chosen procedure. Thus, a thin preparation with relative permanence, and which can be easily handled for microscopic observation, is obtained by insertion of transparent tissue observation chambers into rabbits' ears (Sandison, 1924, 1928; Clark Kirby-Smith, Rex & Williams, 1930). But, the connective tissue which forms in the chamber is the result of a wound healing process and the vessels formed cannot be regarded as normal. Eversion of the cheek pouch of the hamster provides a readily accessible preparation which is normal in structure and function at the outset (Fulton, Jackson & Lutz, 1947; Lutz & Fulton, 1954; Fulton & Lutz, 1957), but it is rather too thick for higher powers of magnification. This can be overcome to some extent by dividing the outer layer of the exteriorised pouch at its summit and stripping off some of the fibrous tissue between the everted layers, but such a method reduces the procedure to a single acute experiment. This limitation also applies to exposing mesenteries for microcirculatory studies (Zweifach, Recently, Goodall,
Research on partners selection of collaborative design based on ant and genetic algorithm

Optimizing collaborative design process can cut down the time to market, thus, acquire competitive advantage. Partner is very important to collaborative design, optimal combination of partners is a prerequisite for collaborative design, picking the wrong partner hurt both productivity and profitability. The issue of partners selection is a combinational optimize, this paper put forward a new method based on combination of genetic algorithm and ant algorithm, using genetic algorithm to generate preliminary pheromone distribution for ant algorithm, then ant algorithm search for optimal result, the method is applied simulation.
Development of Kannada speech corpus for prosodically guided phonetic search engine

Development and availability of spoken language corpora in regional languages is of utmost importance for a multicultural and multilingual country like India. The issues of regional bias, accent, unique style and diversity associated with each geographical region and language will have a significant effect on the performance of speech recognition/synthesis systems. In this paper, collection of speech data in Kannada language for prosodically guided phonetic search engine and the issues involved in transcription are explained. The speech corpus consists of data in three different contexts namely, read mode, conversation mode and extempore mode. A four layered transcription namely, phonetic transcription using IPA symbols, syllabification, pitch marking and break marking is done for the entire data. A baseline recognition system for Kannada language is built using HTK for the data collected in different modes and the results are presented.
Traffic architecture motivated Learning Object organisation in a virtual environment

This paper introduces a structuring method applied to a collection of searched Learning Objects (LOs). Firstly, frequencies of the search keywords are calculated. Then the LOs are grouped under the most ranked keywords. The ranked keywords are taken further into consideration for finding semantic relation metrics that allow us to present the groups visually; for which we have adopted a 3D highway metaphor where these groups are positioned along the dynamically constructed road segments. Since the groups are inter-connected using road networks in accordance to the relation metrics, it leverages the navigational experience of a user while searching for the topic of interest.
TET 1 Is Decreased in Human Prostate Cancer Tissues and Implanted Prostate Cancer Cells Metastasized from Mouse Prostate to Lung

Chih-Hung Hsu,1,11,13 Kai-Lin Peng,1,2,11 Ming-Lun Kang,1,12 Yi-Ren Chen,3,12 Yu-Chih Yang,3 Chin-Hsien Tsai,3,4 Chi-ShuenChu,1,5 Yung-Ming Jeng,6 Yen-TingChen,1,5 Feng-MaoLin,7 Hsien-DaHuang,7 Yun-Yuh Lu,1 Yu-Ching Teng,1,2 Shinn-Tsuen Lin,8 Ruo-Kai Lin,1,14 Fan-Mei Tang,9 Sung-Bau Lee,1,15 Huan Ming Hsu,10 Jyh-Cherng Yu,10,* Pei-Wen Hsiao,3,* and Li-Jung Juan1,2,5,* 1Genomics Research Center, Academia Sinica, Taipei 115, Taiwan, ROC 2Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan, ROC 3Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan, ROC 4Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan, ROC 5Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan, ROC 6Graduate Institute of Pathology, National Taiwan University, Taipei 100, Taiwan, ROC 7Department of Biological Science and Technology, Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 300, Taiwan, ROC 8R&D department, GeneTex Asia Ltd, Hsinchu 300, Taiwan, ROC 9Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan, ROC 10DivisionofGeneralSurgery,Department ofSurgery, Tri-ServiceGeneralHospital,NationalDefenseMedicalCenter, Taipei 114, Taiwan,ROC 11These authors contributed equally to this work 12These authors contributed equally to this work 13Present address: Division of Newborn Medicine, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA 14Present address: Graduate Institute of Pharmacology, Taipei Medical University, Taipei 110, Taiwan, ROC 15Present address: Biotech Research and Innovation Centre (BRIC), University of Copenhagen, DK2200 Copenhagen, Denmark *Correspondence: doc20106@ndmctsgh.edu.tw (J.-C.Y.), pwhsiao@gate.sinica. edu.tw (P.-W.H.), ljjuan@gate.sinica. edu.tw (L.-J.J.) http://dx.doi. org/10.1016/j.celrep. 2012.08. 030
Joinery: Parametric Joint Generation for Laser Cut Assemblies

Laser cutting is widely used by industrial designers and mechanical engineers as a rapid modeling tool. However, designing and fabricating laser cut assemblies can be a complex and tedious process, especially for novice designers. Through our research, we developed Joinery, a parametric joint generation tool for laser cut assemblies. Through Joinery, designers simply define connections between parts of an assembly, while the system generates the joints. Joinery supports fabrication-aware design through six different joint profiles that cater to different material and design needs. In this paper, we illustrate the use of Joinery as a creativity support tool in an industrial design process, and present several artifacts resulting from the tool. In addition, we discuss our findings from deploying this system in a college-level industrial design class.
Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size

ABSTRACT The proteins that form vertebrate gap junctions, the connexins, are highly regulated and have short (<2 hour) half-lives. Phosphorylation of connexin43 (Cx43) affects gap junction assembly, channel gating and turnover. After finding dramatic effects on gap junctions with Akt inhibitors, we created an antibody specific for Cx43 phosphorylated on S373, a potential Akt substrate. We found S373 phosphorylation in cells and skin or heart almost exclusively in larger gap-junctional structures that increased dramatically after wounding or hypoxia. We were able to mechanistically show that Akt-dependent phosphorylation of S373 increases gap junction size and communication by completely eliminating the interaction between Cx43 and ZO-1. Thus, phosphorylation on S373 acts as a molecular ‘switch’ to rapidly increase gap-junctional communication, potentially leading to initiation of activation and migration of keratinocytes or ischemic injury response in the skin and the heart, respectively.