Miracle-dz/UniFAR-FTUs huggingface dataset:
Translation and validation of the Perinatal Grief Scale in a sample of Greek women with perinatal loss during the 1st and 2nd trimester of pregnancy

Abstract Objective: To translate and validate the Perinatal Grief Scale (PGS) (short version) in a sample of Greek women with perinatal loss during the first and second trimester of pregnancy. Methods: One hundred seventy-six women were approached a few hours after the loss. Along with the PGS, three more questionnaires were completed: the Edinburgh Postnatal Depression Scale (EPDS), the Hospital Anxiety and Depression Scale (HADS) and the State-Trait Anxiety Inventory (STAI), in order to assess the convergent validity of the PGS. Results: Total sample mean age was 34.1 years (SD = 5.2). Mean values and Cronbach’s alpha coefficients for PGS subscales exceeded the minimum reliability standard of 0.70. Mean score for “Active grief” was 31.47 (SD = 9.31), for “Difficulty Coping” was 23.13 (SD = 7.54) and for “Despair” was 21.07 (SD = 7.07). By applying Pearson’s correlation coefficients, PGS subscales positively correlated with scores on EPDS, STAI and HADS. Conclusions: The PGS Greek version is a reliable instrument in terms of internal consistency and the Cronbach’s alpha coefficients are high. The Greek version of PGS can be a useful instrument for the detection of the psychological impact after a perinatal loss and it has implications for both scientific research and clinical routine.
Antidepressant-like effects of P2 purinergic antagonist PPADS is dependent on serotonergic and noradrenergic integrity

Depression is a common mental disorder affecting around 350 million of individuals globally. The available antidepressant drug monotherapy is far from ideal since it has an efficiency of approximately 60% and takes around 3-4 week to achieve clinical improvement. Attention has been paid to the purinergic signaling regarding neuropathological mechanisms, since it might be involved in psychiatric disorders, such as depression. In fact, blockade of purinergic P2X receptors induces antidepressant-like effects in preclinical models. However, the mechanisms involved in this effect are not yet completely understood. The present work investigated the interplay between a P2X receptor antagonist (PPADS) and clinically used antidepressant drugs on the forced swimming test, an animal model predictive of antidepressant effect. We observed significant synergistic effect of PPADS combined with sub-effective doses of fluoxetine or reboxetine in the FST. Moreover, depletion of serotonergic or noradrenergic systems, with PCPA and DSP-4 treatment, respectively, blocked the antidepressant-like effect of PPADS. No increase in locomotion, a possible source of confusion on FST data, was detected in any of the treated groups. Our results indicate the antidepressant-like effect of PPADS depends on the integrity of serotonergic and noradrenergic transmission.
Pricing-Based Interference Coordination for D2D Communications in Cellular Networks

A pricing-based joint spectrum and power allocation framework is proposed for decentralized interference coordination among device-to-device (D2D) communications and cellular users (CUs), with the quality-of-service guarantee. The interlayer interference from D2D pairs to CUs is controlled by the base station through setting a price for each D2D channel usage. The intralayer interference among D2D pairs is mitigated distributively using a game-theoretic approach, where the D2D pairs compete for the spectrum until a Nash equilibrium is achieved. The effectiveness of the proposed strategy, including a practical scheme with limited signaling overhead, is demonstrated through comparing with a centralized scheme.
Feature-guided Convolution for Pencil Rendering

We re-render a photographic image as a simulated pencil drawing using two independent line integral convolution (LIC) algorithms that express tone and feature lines. The LIC for tone is then applied in the same direction across the image, while the LIC for features is applied in pixels close to each feature line in the direction of that line. Features are extracted using the coherent line scheme. Changing the direction and range of the LICs allows a wide range of pencil drawing style to be mimicked. We tested our algorithm on diverse images and obtained encouraging results.
Genitive variation in English : conceptual factors in synchronic and diachronic studies

This monograph is an empirical study of a particular type of grammatical variation - genitive variation in English. Comparing the results of a Modern English experimental study and historical evidence for the development of genitive variation, the main empirical finding of this study is that the s-genitive has become more productive again from late Middle to Modern English. A new theoretical approach to grammatical variation is proposed which places the choice of genitive construction into the mind of individual language users and, in so doing, tries to account for the observed change.
Best practices and future visions for search user interfaces: a workshop

This one-day workshop will create a roadmap of current best practices and future needs for search user interface design. It will provide an interactive forum for participants to actively discuss submitted papers, industry trends, and gaps in our knowledge. Participants will come away with new research findings, key contacts, and identified opportunities for research. Participants will be both practitioners and academics to balance the discussion between theory and application.
Prime-boost Vaccination based on DNA and Protein-loaded Microspheres for Tuberculosis Prevention

We evaluated the use of a vaccine formulation based on a mixture of two different PLGA microspheres, composed by faster and slower release profiles, containing DNA encoding hsp65 and the recombinant hsp65 protein, respectively, aiming to DNA priming and protein boost after a single dose vaccination. The combination of PLGA50:50 microspheres containing DNA-hsp65 and trehalose dimycolate (TDM) with PLGA75:25 microspheres containing recombinant hsp65 (prime-boost Me) was able to induce high levels of anti-hsp65 specific antibodies. The serum levels of these specific antibodies remained high during 90 days after vaccination, whereas the DNA Me formulation based only in DNA-hsp65 plus TDM-loaded microspheres was not able to sustain the high antibody levels during the same period. Production of IFN-γ was significant in animals vaccinated with both formulations, while the prime-boost Me vaccinated mice sustained higher levels of this cytokine during all the evaluation period. Thus, prime-boost strategy by using biodegradable microspheres seems to be a promising strategy to stimulate long-lasting immune response.
Isolated Cells or Cell Substitutes as Cellular Replacement Parts

Tissue engineering is an interdisciplinary science that involves the use of biological sciences and engineering to develop tissues that restore, maintain, or enhance tissue function. However, to realize the dream of creating off-the-shelf organs for transplantation, a renewable source of cells is required. Embryonic stem (ES) cells have the potential to provide such a source of cells for tissue engineering applications, because of their ability to differentiate to all somatic cells, and their unlimited proliferative capability. However, to use ES cells in tissue engineering a number of challenges must be addressed regarding methods to direct ES cell differentiation, overcome host’s immune rejection, prevent tumor formation, scale-up the production process, and control scaffold properties better. This chapter will introduce tissue engineering approaches, and the role of ES cells in various tissue engineering applications.
The Effect of a Low Concentration of Hypochlorous Acid on Rhinovirus Infection of Nasal Epithelial Cells

Background Low concentrations of hypochlorous acid (HOCl) have been shown to exhibit both antibacterial and anti-influenza virus activity, but HOCl still has not been used to kill human rhinovirus (HRV). To model the antiviral effect of nasal irrigation with low-level HOCl in patients with the common cold, we tested the effects of a low concentration of HOCl on HRV infection of primary human nasal epithelial cells (HNEC). Methods Cells were infected with HRV for 24 hours and treated with HOCl three times, for 5 minutes each time, at 12 hour intervals. The effects of HOCl on rhinovirus-induced secretion of IL-6 and IL-8 were assessed by ELISA and HRV replication was determined by viral titration. Results HOCl treatment significantly inhibited HRV-induced secretion of IL-6 and IL-8 and significantly reduced viral titer. The effects of HOCl peaked at 1 minute after HOCl generation and decreased thereafter. Conclusion These in vitro findings indicate that nasal irrigation with low-level HOCl solution may improve clinical symptoms in patients with the common cold.
Absence of 4 1BB gene function exacerbates lacrimal gland inflammation in autoimmune-prone MRL-Faslpr mice.

PURPOSE To define the role of endogenous 4-1BB (an important T-cell costimulatory molecule) in the regulation of ocular disease, MRL-Fas(lpr) mice deficient in 4-1BB were generated, and their lacrimal gland function was studied. METHODS 4-1BB(-/-)MRL/MpJ-Tnfrs(lpr)/Tnfrs(lpr) (lpr/4-1BB(-/-)) mice were generated and used at the ninth backcross. Mice were killed at various times, and lacrimal gland cellularity was analyzed by flow cytometry. Tear and tissue samples were analyzed by Western blotting for the presence of aquaporin 5 (AQP5) and 120-kDa fragments of alpha-fodrin. Cytokine expression of lacrimal glands was assessed by flow cytometry and RT-PCR analysis. RESULTS Absence of the 4-1BB gene function in lpr mice resulted in early and increased infiltration of mononuclear cells into lacrimal glands compared with 4-1BB intact lpr mice. The severity of lesions in lpr/4-1BB(-/-) mice was closely associated with enhanced accumulation of primarily CD4(+) T cells within the lacrimal glands and with increased expression of IL-4. Elevated levels of AQP5 and cleaved 120-kDa fragments of alpha-fodrin were found in tears and lacrimal gland lysates, respectively, of lpr/4-1BB(-/-) but not lpr/4-1BB(+/+) mice. CONCLUSIONS Deletion of 4-1BB in lpr mice accelerates lacrimal gland lesions through increased CD4(+) T-cell infiltration and their production of immune modulators.
The Chronicle of Hydatius and The Consularia Constantinopolitana

Part 1 Hydatii limmici chronica subdita: Hydatius and his "Chronicle" manuscripts and editions chronology Lacunae, fragments, and interpolations presentation of the text previous editions of MS B sigla text and translation. Part 2 The "Consularia Constantinopolitana": prolegomena analysis of the pre-389 material Hydatius and the "Consularia" analysis of the post-388 material presentation of the text previous editions of the "Consularia" sigla text.
Output, Tissue Levels, and Synthesis of Acetylcholine During and After Transient Forebrain Ischemia in the Rat

Abstract: Biochemical changes in the rat brain cholinergic system during and after 60 min of ischemia were studied using a four‐vessel occlusion model. Extracellular acetylcholine (ACh) concentrations in the unanesthetized rat hippocampus markedly increased during ischemia and reached a peak (about 13.5 times baseline levels) at 5–10 min after the onset of ischemia. At 2–5 h after reperfusion, extracellular ACh concentrations were reduced to 64–72% of the levels of controls. ACh levels in the hippocampus, striatum, and cortex decreased significantly during ischemia and exceeded their control values just after reperfusion. A significant increase in hippocampal ACh level after 2 days of reperfusion and a decrease in [14C]ACh synthesis from [14C]glucose in hippocampal slices excised at 2 days after reperfusion were observed. The extracellular concentrations and tissue levels of choline markedly increased after ischemia. These results show that ACh is markedly released into the extracellular space in the hippocampus during ischemia, and they suggest that ACh synthesis is activated just after reperfusion and that cholinergic activity is reduced after 2–48 h of reperfusion in the hippocampus.
Methods and modeling: fiction or useful reality?

In this panel, the key issue is whether methods and modeling are useful for HCI design practice and, in particular, user-interface design. More precisely, can scenarios, essential use cases, GOMS and Cognitive Walkthrough really help practitioners? It seems that mainstream practice only rudimentarily applies such methods. Why is it so difficult to introduce them into the work done in the trenches?
Performance of intent-based virtualized network infrastructure management

This paper presents the definition and a proof-of-concept implementation of an intent-based northbound interface (NBI) used to orchestrate dynamic service chaining of Virtualized Network Functions (VNFs) by actively controlling the underlying network infrastructure through vendor-independent, technology-agnostic policies. The proof of concept considers a general scenario where VNFs are hosted in different SDN domains, possibly interconnected by non-SDN domains. Being implemented as part of a Virtualized Infrastructure Manager, the proposed NBI is compliant with the ETSI NFV management and orchestration specifications, as well as with the recent ONF definition of intent-based NBI. The case of a network operator that provides adaptive quality of service enforcement in a multi-tenant scenario is considered. Responsiveness of the intent-based NBI is experimentally evaluated under increasing load, proving the correct functionality and the scalability potentials of the proposed approach.
A decentralized and service‐based solution for data mediation: the case for data providing service compositions

The last few years have seen an increase in the use of e‐services as a natural consequence of the service‐based economy growth. However, the distributed nature of services can raise several heterogeneity problems that can hamper the widespread adoption of service‐oriented architectures (SOA). In this paper, we are interested in data heterogeneity problems that can occur when using composite services. We propose a service‐based approach for automatically inserting appropriate mediation services in service compositions to resolve structural heterogeneities in their data flow. This mediation is ensured through a special kind of Web services called data mapping Web services. In addition, in order to be in agreement with the distributed nature of the Web, we propose a decentralized solution to publish/discover these services. We demonstrate how our approach applies to the data structural heterogeneity problem in data providing service compositions as a particular data heterogeneity case. Provided experimental results show that our approach is efficient in realistic situations. Copyright © 2013 John Wiley & Sons, Ltd.
Letrozole as the first-line treatment of infertile women with poly cystic ovarian syndrome (PCOS) compared with clomiphene citrate: A clinical trial

Background: The purpose of this study was to determine the efficacy and safety of letrozole on ovulation induction and pregnancy in comparison with clomiphene citrate in PCOS patients. Materials and Methods: The study was based on prospective randomized clinical trial comparing the efficacy of letrozole as the first-line management of the PCOS patients in comparison to clomiphene citrate during 2009 to 2011 and was performed in one private infertility clinic. The study included 100 patients divided into 2 equal groups. Results: Pregnancy occurred in 29 of 50 patients in letrozole group (58%) and 24 of 51 patients in clomiphene group (47%). The difference was not statistically significant (P value = 0.23). Thirty patients in clomiphene group and 36 patients in letrozole group showed regular menses after or during the treatment course. No significant difference between the 2 groups was observed (P value = 0.21). Conclusion: Our findings suggest letrozole and clomiphene citrate are equally effective for induction of ovulation and achieving pregnancy in patients with PCOS.
Nonlinear Observer for 3D Rigid Body Motion Estimation Using Doppler Measurements

This work presents a nonlinear observer that estimates the translational and rotational motion of a rigid body based on measurements of configuration (pose), angular velocity, and radial velocity as well as modeled forces and torques. The radial velocity measurements are provided by a single direction Doppler sensor. Using a conveniently defined Lyapunov function, a nonlinear observer on the Special Euclidean Group (SE(3)) is derived and almost globally stability is guaranteed. The resulting estimation error is almost globally exponentially convergent for sufficiently rich motion. Numerical simulation results are presented that illustrate the performance of the proposed solution.
A mutation allowing an mRNA secondary structure diminishes translation of Saccharomyces cerevisiae iso-1-cytochrome c

The CYC1-239-O mutation in the yeast Saccharomyces cerevisiae produces a -His-Leu- replacement of the normal -Ala-Gly- sequence at amino acid positions 5 and 6, which lie within a dispensable region of iso-1-cytochrome c; this mutation can accommodate the formation of a hairpin structure at the corresponding site in the mRNA. The amount of the altered protein was diminished to 20% of the wild-type level, whereas the amount of the mRNA remained normal. However, in contrast to the normal CYC1+ mRNA that is associated mainly with four to seven ribosomes, the bulk of the CYC1-239-O mRNA is associated with one to four ribosomes. These results suggest that the stable secondary structure within the translated region of the CYC1 mRNA diminishes translation by inhibiting elongation.
ProGuard: Detecting Malicious Accounts in Social-Network-Based Online Promotions

Online social networks (OSNs) gradually integrate financial capabilities by enabling the usage of real and virtual currency. They serve as new platforms to host a variety of business activities, such as online promotion events, where users can possibly get virtual currency as rewards by participating in such events. Both OSNs and business partners are significantly concerned when attackers instrument a set of accounts to collect virtual currency from these events, which make these events ineffective and result in significant financial loss. It becomes of great importance to proactively detecting these malicious accounts before the online promotion activities and subsequently decreases their priority to be rewarded. In this paper, we propose a novel system, namely ProGuard, to accomplish this objective by systematically integrating features that characterize accounts from three perspectives including their general behaviors, their recharging patterns, and the usage of their currency. We have performed extensive experiments based on data collected from the Tencent QQ, a global leading OSN with built-in financial management activities. Experimental results have demonstrated that our system can accomplish a high detection rate of 96.67% at a very low false positive rate of 0.3%.
Designing Health Communication Campaigns: What Works?

Introduction PART ONE: OVERVIEW The Challenge of Health Behavior Change One Solution Health Communication Campaigns Two Examples of Health Communication Campaigns The Comparative Synthesis Study Substance Abuse and High-Risk Youth Setting the Agenda for the Issue of Drugs PART TWO: GENERALIZATIONS ABOUT HEALTH COMMUNICATION CAMPAIGNS Overview Generalizations about Health Communication Campaigns Discussion PART THREE: INTERVIEWS WITH CAMPAIGN DESIGNERS/EXPERTS Georgetown University - Elaine Bratic Arkin Entertainment Industry Coalition on AIDS - Warren J Ashley Michigan State University - Charles Atkin Human Interaction Research Institute - Thomas E Backer Los Angeles Times - Edwin Chen Johns Hopkins University - Patrick C Coleman Entertainment Industries Council - Larry Deutchman Entertainment Industries Council - Brian Dyak Brookfield Productions - Fern Field International Institute of Rural Reconstruction, Philippines - Juan M Flaviar University of Illinois - Brian Flay Stanford University - June Flora University of Maryland - Vicki Freimuth The University of Texas at Austin - Kipling J Gallion Population Communications - Robert W Gillespie University of Pennsylvania - Robert Hornik Institute for Communication Research - Jose Ruben Jara University of Southern California - C Anderson Johnson Mediascope - Marcy Kelly Johns Hopkins University - Lawrence Kincaid Center for Risk Communication - David McCallum Scott Newman Center - Jacqueline E McDonald Freedom Forum Media Studies Center - John V Pavlick University of Southern California - Mary Ann Pentz Rutgers University - Ronald E Rice University of Southern California - Everett M Rogers University of Wisconsin - Madison - Charles Salmon Entertainment Industries Council - Larry Stewart University of California at Berkeley - Lawrence Wallack PART FOUR: IMPLICATIONS AND FUTURE DIRECTIONS Implications for Campaign Design Implications for Future Research
An Evaluation of the use of Clustering Coefficient as a Heuristic for the Visualisation of Small World Graphs

Many graphs modelling real-world systems are characterised by a high edge density and the small world properties of a low diameter and a high clustering coefﬁcient. In the "small world" class of graphs, the connectivity of nodes follows a power-law distribution with some nodes of high degree acting as hubs. While current layout algorithms are capable of displaying two dimensional node-link visualisations of large data sets, the results for dense small world graphs can be aesthetically unpleasant and difﬁcult to read. In order to make the graph more understandable, we suggest dividing it into clusters built around nodes of interest to the user. This paper describes a graph clustering using the average clustering coefﬁcient as a heuristic for determining which node a vertex should be assigned to. We propose that the use of clustering coefﬁcient as a heuristic aids in the formation of high quality clusters that consist of nodes that are conceptually related to each other. We evaluate the impact of using the clustering coefﬁcient heuristic against other approaches. Once the clustering is performed we lay out the graph using a force directed approach for each clustering individually. Categories and Subject Descriptors (according to ACM CCS) : G.2. 2 [Graph Theory]: Graph AlgorithmsI.5. 3 [Clustering]: AlgorithmsF.2. 2 [ Nonnumerical Algorithms and Problems]: Routing and layout
Emergency mental health admissions for children: A naturalistic study

Objective: Emergency mental health admissions (EA) for children under 13 years are not routinely offered in the UK, which may be related to preconceptions about their safety, appropriateness and acceptability. Our aim was to evaluate routinely offered EA of children in a national unit over a three-year period. Method: A retrospective, naturalistic study was conducted, comparing EA with planned admissions (PA) in terms of children’s functioning on admission and discharge, clinical characteristics, significant risk-related incidents and parental and children satisfaction. Results: EA children (N=47) did not differ from PA children (N=35) in age, length of admission, medication treatment, significant risk-related incidents, functioning at discharge, access to education at discharge and satisfaction. EA children had lower functioning and were less likely to have been out of education on admission. Parental satisfaction in EA was higher compared to PA. Conclusions: EA for children are an appropriate, clinically indicated and safe alternative to PA, associated with higher parental satisfaction.