Miracle-dz/UniFAR-FTUs huggingface dataset:
HDA1 and HDA3 Are Components of a Yeast Histone Deacetylase (HDA) Complex*

Histone acetylation is maintained through the action of histone acetyltransferases and deacetylases and has been correlated with increased gene activity. To investigate the functional role of these enzymes in the regulation of transcription, we have purified from Saccharomyces cerevisiae two histone deacetylase activities, HDA and HDB, with molecular masses of ∼350 and 600 kDa, respectively. In vitro, the HDA activity deacetylates all four core histones, has a preference for histone H3, and is strongly inhibited by trichostatin A (a specific inhibitor of histone deacetylases). HDB is considerably less sensitive to trichostatin A. We report the extensive purification of the HDA activity and the identification of peptides (p75, p73, p72, and p71) whose presence correlates with deacetylase activity on native polyacrylamide gels. An antibody to p75 immunoprecipitates peptides with molecular masses similar to those in the 350-kDa complex. Additionally, antibodies to p75 and p71 specifically precipitate histone deacetylase activity and co-immunoprecipitate each other. Gene disruptions of p75 (HDA1) or p71 (HDA3) cause the loss of the 350-kDa (but not the 600-kDa) activity from our chromatography profiles. These data argue strongly that HDA1 and HDA3 are subunits of the HDA complex, which is structurally distinct from the second, HDB complex.
Single stage three-level MPPT inverter for solar supplied systems

In this study, a single stage, three-phase, three-level neutral point clamped inverter is designed for grid connected renewable energy systems. The proposed voltage source inverter is operated in current controlled mode and a PI current controller is used for the production of switching pattern. Also the proposed inverter is operated in parallel with public grid by using phase locked loop method. Maximum power point tracking process which is aimed to obtain maximum energy from the supply is performed via the proposed inverter without using any additional DC-DC converter. Maximum power point tracking algorithm generates the current reference for the current controller. Results of experimental studies show that inverter output current is in phase with line and unity power factor operation is obtained. Also inverter output current total harmonic distortion is measured as 3.95%. This value is in the limits of international standards (5%).
Development and assessment of a new early scoring system using non-specific clinical signs and biological results to identify children and adult patients with a high probability of infective endocarditis on admission

Objectives The aim of this study was to assess whether non-specific clinical signs or biological results can identify patients with a high probability of infective endocarditis (IE) to improve outcome. Patients and methods All patients tested for IE were included in a cohort and classified according to the modified Duke criteria. Patients with rejected endocarditis served as controls. Univariate and multivariate analyses were performed, and a score was calculated by adding 1 when a variable independently associated with IE (excluding major Duke criteria) was present and 0 when the variable was absent. A second score for patients with prior valvular damage (PVD) was also used. Scores were evaluated using the ROC curve method. Results IE was diagnosed in 402 of 2039 participants (19.7%). By multivariate analysis, PVD, fever, emboli, stroke, splenomegaly, finger clubbing, leucocytosis and erythrocyte sediment rate >50 were independently associated with IE. The rate of IE increased significantly from 4% (10/254) for a score of 0 to 83% (10/12) for a score of 6 in all patients, and from 9.5% (23/241) to 100% (10/10) in patients with PVD. The area under the ROC curve was 0.75 for the first score and 0.7 for the second. In a prospective study of 117 patients with suspicion of IE, the proportion of confirmed IE was 19% and the area under the ROC curve was 0.72. Conclusions This simple score can be used to identify patients with a high probability of IE, in the emergency room or on admission, to speed up diagnosis, or to initiate empirical antimicrobial therapy without replacing the modified Duke criteria.
PhoneyC: A Virtual Client Honeypot

The number of client-side attacks has grown significantly in the past few years, shifting focus away from defendable positions to a broad, poorly defended space filled with vulnerable clients. Just as honeypots enabled deep research into server-side attacks, honeyclients can permit the deep study of client-side attacks. A complement to honeypots, a honeyclient is a tool designed to mimic the behavior of a user-driven network client application, such as a web browser, and be exploited by an attacker's content. These systems are instrumented to discover what happened and how. This paper presents PhoneyC, a honeyclient tool that can provide visibility into new and complex client-side attacks. PhoneyC is a virtual honeyclient, meaning it is not a real application but rather an emulated client. By using dynamic analysis, PhoneyC is able to remove the obfuscation from many malicious pages. Furthermore, PhoneyC emulates specific vulnerabilities to pinpoint the attack vector. PhoneyC is a modular framework that enables the study of malicious HTTP pages and understands modern vulnerabilities and attacker techniques.
Privacy preserving big histogram aggregation for spatial crowdsensing

The popularity of mobile devices has far expanded the application scenarios of spatial crowdsensing, due to its ability to provide fine-grained multi dimensional sensor readings associated with location information. Privacy is one of the fundamental issues in crowdsensing, as these location-based sensor readings may reveal identities or activities of participants. In this paper, we adopts the state-of-art location privacy definition geo-indistinguishability, provide an efficient and effective privacy preserving histogram aggregation mechanism BFMM (Bit Flipping Matrix Mechanism) for fine-grained multi dimensional location-based data. Theoretical analyses and experimental results demonstrate the efficiency and effectiveness of our approach for fine-grained multidimensional location-based data. Specifically, the aggregation accuracy of our approach averagely outperforms existing methods by a factor of number of buckets in the histogram.
A survey of SiO 5 -> 4 emission towards outflows from massive young stellar objects

Results are presented of a survey of SiO 5 → 4 emission observed with the James Clerk Maxwell Telescope towards a sample of outflows from massive young stellar objects. The sample is drawn from a single-distance study by Ridge & Moore and allows the reasons that govern the detectability of SiO to be explored without the bias introduced by observing sources at different distances. This is the first such unbiased survey of SiO emission from massive outflows. In a sample of 12 sources, the 5 → 4 line was detected in five, a detection rate of 42 per cent. This detection rate is higher than that found for a sample of low-luminosity outflow sources, although for sources of comparable luminosity, it is in good agreement with the results of a previous survey of high-luminosity sources. For most of the detected sources, the 5 → 4 emission is compact or slightly extended along the direction of the outflow. NGC 63341 shows a clear bipolar flow in the 5 → 4 line. Additional data were obtained for W3-IRS5, AFGL 5142 and W75N for the 2 → 1 transition of SiO using the Berkeley-Illinois-Maryland Association millimetre interferometer. There is broad agreement between the appearance of the SiO emission in both lines, though there are some minor differences. The 2 → 1 emission in AFGL 5142 is resolved into two outflow lobes which are spatially coincident on the sky, in good agreement with previous observations. In general, the SiO emission is clearly associated with the outflow. Simple analysis and radiative transfer modelling of the detected sources yields similar SiO column densities. The abundance of SiO is ∼ 0.1-7.0 x 10 -9 , and the H 2 number density is within a factor of 2 of 10 5 cm -3 . However, the temperature is not constrained over the range 50-150 K. The primary indicator of SiO 5 → 4 detectability is the outflow velocity, that is, the presence of SiO is an indicator of a high-velocity outflow. This result is consistent with the existence of a critical shock velocity required to disrupt dust grains and subsequent SiO formation in post-shock gas. There is also weak evidence that higher luminosity sources and denser outflows are more likely to be detected.
Hierarchical Annotation Management Method for Activity Information Collecting System

Recently, researches for activity recognition with sensor data have been increased by the spread of smart phones with 3-axis accelerometers and gyroscopes. However, collecting various sensor data from many people is difficult. To solve this problem, we developed activity collecting platform using various client software. Moreover, annotating continuous activity data is also an important task. However, this task requires a lot of work by hands. Moreover, an activity has a complex structure, and annotation by human often contains ambiguity. For this reason, a system needs to support work so that a worker may add annotation efficiently and accuracy. Therefore, we propose the annotation software which has the function of hierarchical segmentation and hierarchical annotation.
Comparative Study on CBIR based by Color Histogram, Gabor and Wavelet Transform

Content-Based Image Retrieval (CBIR), also known as query by image content (QBIC) Content-based image retrieval (CBIR) system helps users to retrieve relevant images based on their contents. Content Based Image Retrieval (CBIR) technologies provide a method to find images in large databases by using unique descriptors from a trained image. The image
Modelling and control of process industry batch production systems

Abstract Many models of process industry batch production systems are of a continuous-time/discrete-event (CT/DE) nature: physical processes are modelled using CT specifications, operating procedures are modelled using DE specifications. For scheduling of batch production systems, special purpose tools are available. The Chi language is a CT/DE language with high level DE language elements. This makes it possible to model physical processes using CT and/or DE specifications. It also makes it possible to solve scheduling problems in Chi, and to integrate the scheduler with the model of the batch production systems. The advantages of this approach are illustrated by means of four case studies.
TADPOL: A 1.3 mm SURVEY OF DUST POLARIZATION IN STAR-FORMING CORES AND REGIONS

We present λ 1.3 mm Combined Array for Research in Millimeter-wave Astronomy observations of dust polarization toward 30 star-forming cores and eight star-forming regions from the TADPOL survey. We show maps of all sources, and compare the ∼2. ″5 resolution TADPOL maps with ∼20″ resolution polarization maps from single-dish submillimeter telescopes. Here we do not attempt to interpret the detailed B-field morphology of each object. Rather, we use average B-field orientations to derive conclusions in a statistical sense from the ensemble of sources, bearing in mind that these average orientations can be quite uncertain. We discuss three main findings. (1) A subset of the sources have consistent magnetic field (B-field) orientations between large (∼20″) and small (∼2.″5) scales. Those same sources also tend to have higher fractional polarizations than the sources with inconsistent large-to-small-scale fields. We interpret this to mean that in at least some cases B-fields play a role in regulating the infall of material all the way down to the ∼1000 AU scales of protostellar envelopes. (2) Outflows appear to be randomly aligned with B-fields; although, in sources with low polarization fractions there is a hint that outflows are preferentially perpendicular to small-scale B-fields, which suggests that in these sources the fields have been wrapped up by envelope rotation. (3) Finally, even at ∼2. ″5 resolution we see the so-called polarization hole effect, where the fractional polarization drops significantly near the total intensity peak. All data are publicly available in the electronic edition of this article.
Nonlinear band-pass filtering using the TV transform

A distinct family of nonlinear filters is presented. It is based on a new formalism, defining a nonlinear transform based on the TV-functional. Scales in this sense are related to the size of the object and its contrast. Edges are very well preserved and selected scales of the object can be either selected, removed or enhanced. We compare the behavior of the filter to other filters based on Fourier and wavelets transforms and present its unique qualities.
S2Directory A Framework for Object-Directory Mapping with Dynamic Implementation Injection

Object models adopted in the object oriented software development reflect complex relations that exist between various entities in the real world. On the other hand, directory models adopted in directory service technologies map various relations into tree structures. Therefore, developing directory services by object oriented languages require writing lengthy procedures that bridge the gaps between object models and directory models. To overcome this drawback, in this paper, we propose a new technology named Object- Directory Mapping. We also present a Java based framework S2Directory to prove the effectiveness of the concept of Object-Directory Mapping. Implementation details are also given together with new dynamic implementation injection techniques.
Line Orthogonality in Adjacency Eigenspace with Application to Community Partition

Different from Laplacian or normal matrix, the properties of the adjacency eigenspace received much less attention. Recent work showed that nodes projected into the adjacency eigenspace exhibit an orthogonal line pattern and nodes from the same community locate along the same line. In this paper, we conduct theoretical studies based on graph perturbation to demonstrate why this line orthogonality property holds in the adjacency eigenspace and why it generally disappears in the Laplacian and normal eigenspaces. Using the orthogonality property in the adjacency eigenspace, we present a graph partition algorithm, AdjCluster, which first projects node coordinates to the unit sphere and then applies the classic k-means to find clusters. Empirical evaluations on synthetic data and real-world social networks validate our theoretical findings and show the effectiveness of our graph partition algorithm.
How Often Do Managers Withhold Information?

We estimate a dynamic model of voluntary disclosure, using annual management forecasts of earnings, that features a manager with price motives and an uncertain, but persistent, information endowment. Our estimates imply that: (1) managers face disclosure frictions 35 percent of the time; (2) conditional on being informed, managers withhold information 17 percent of the time; and (3) conditional on being silent, managers possess information 24 percent of the time. Managers' strategic withholding motives increase investors' uncertainty about earnings by 3 percent. We find that managers' price motives reduce strategic withholding by one-third in response to investors' increased skepticism in the event of non-disclosure. JEL Classifications: D82; D83; G17.
Improved genome-wide localization by ChIP-chip using double-round T7 RNA polymerase-based amplification

Chromatin immunoprecipitation combined with DNA microarrays (ChIP-chip) is a powerful technique to detect in vivo protein–DNA interactions. Due to low yields, ChIP assays of transcription factors generally require amplification of immunoprecipitated genomic DNA. Here, we present an adapted linear amplification method that involves two rounds of T7 RNA polymerase amplification (double-T7). Using this we could successfully amplify as little as 0.4 ng of ChIP DNA to sufficient amounts for microarray analysis. In addition, we compared the double-T7 method to the ligation-mediated polymerase chain reaction (LM-PCR) method in a ChIP-chip of the yeast transcription factor Gsm1p. The double-T7 protocol showed lower noise levels and stronger binding signals compared to LM-PCR. Both LM-PCR and double-T7 identified strongly bound genomic regions, but the double-T7 method increased sensitivity and specificity to allow detection of weaker binding sites.
Agricultural Shocks and Off-farm Labor Market Decisions for Rural Households in Kenya ∗

This paper analyzes the determinants of participation and earnings from the offfarm labor market for rural households in Kenya. We specifically explore how these rural households respond to risky agricultural production environments and existence of ex post adjustments in off-farm labor supply in response to unexpected rainfall shocks. While controlling for a wide range of educational, demographic, and other locational factors, we look at how long-term weather risks and specific rainfall shocks influence a household’s decision to engage in the off-farm labor market and on the earnings generated from such labor. Results indicate that these rural households engage in offfarm work as a long-term strategy to deal with anticipated weather risks to their farming operations. The study does not however show major short term adjustments in off-farm engagements as a result of specific, unexpected rainfall shocks. We find that these rural households rely on remittance income and petty agricultural wage labor in response to such unexpected short-term rainfall shocks. Holding other factors constant, and conditional on participation, households in areas with a more productive local agriculture tend to earn more from off-farm work especially in self-employment than those living in regions with a less productive agriculture. As expected, a vibrant local economy in form of public investment does increase the probability of participation.
Relationships Among an Individual Intelligence Test and Two Air Force Screening and Selection Tests.

Abstract : With the implementation of the all volunteer force concept, the Air Force must insure that the objectively measurable range of ability in its manpower pool is being utilized. This is especially true for minority groups who have been categorized and channeled into military career areas based upon their performance on two selection tests: the Armed Forces Qualification Test (AFQT) and the Airman Qualifying Examination (AQE). To investigate the relationship of the AFQT and AQE to the general mental ability of different racial groups of airmen, a sample of 100 black and 100 white Air Force basic trainees was administered an established test of general mental ability, the Wechsler Adult Intelligence Scale (WAIS). The verbal, performance, and full scale IQ scores of the white and black airmen were compared to their AFQT scores and their four AQE aptitude indexes. Significant differences between black and white airmen were found on the AFQT, the four AQE aptitude indexes, and the three WAIS IQs. Regression analyses demonstrated most differences to be interaction effects between race and Air Force test scores. Implications for further research into Air Force airmen selection tests were discussed.
Multimedia Annotation with Multilingual Input Methods and Search Support

A tool set to create complex multimedia/multimodal annotations and to exploit them is described. Due to its possibility to flexibly define tiers and associate languages/writing systems with it and to even mix characters from different writing systems it is a tool which is especially suitable for work in multilingual environments. Also the search interface supports the multilingual features allowing to search for complex patterns in the annotations.
Some new cooperative coverage facility location games

In this paper we introduce and analyze new classes of cooperative games related to facility location models defined on general metric spaces. The players are the customers (demand points) in the location problem and the characteristic value of a coalition is the cost of serving its members. Specifically, the cost in our games is either the service radius or the diameter of the coalition. We study the existence of core allocations for these games, focusing on network spaces, i.e., finite metric spaces induced by undirected graphs and positive edge lengths, and on finite dimension vector spaces endowed with a norm (Rd).
Colletotrichum – current status and future directions

A review is provided of the current state of understanding of Colletotrichum systematics, focusing on species-level data and the major clades. The taxonomic placement of the genus is discussed, and the evolution of our approach to species concepts and anamorph-teleomorph relationships is described. The application of multilocus technologies to phylogenetic analysis of Colletotrichum is reviewed, and selection of potential genes/loci for barcoding purposes is discussed. Host specificity and its relation to speciation and taxonomy is briefly addressed. A short review is presented of the current status of classification of the species clusters that are currently without comprehensive multilocus analyses, emphasising the orbiculare and destructivum aggregates. The future for Colletotrichum biology will be reliant on consensus classification and robust identification tools. In support of these goals, a Subcommission on Colletotrichum has been formed under the auspices of the International Commission on Taxonomy of Fungi, which will administer a carefully curated barcode database for sequence-based identification of species within the BioloMICS web environment.
A general cloud firewall framework with dynamic resource allocation

Cloud is becoming a dominant computing platform. However, we see few work on how to protect cloud data centers. As a cloud usually hosts many different type of applications, the traditional packet level firewall mechanism is not suitable for cloud platforms in case of complex attacks. It is necessary to perform anomaly detection at the event level. Moreover, protecting objects are more diverse than the traditional firewall. Motivated by this, we propose a general framework of cloud firewall, which features event level detection chain with dynamic resource allocation. We establish a mathematical model for the proposed framework. Moreover, a linear resource investment function is proposed for economical dynamical resource allocation for cloud firewalls. A few conclusions have been extracted for the reference of cloud service providers and designers.