Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of perioperative statins on patient outcomes after noncardiac surgery: a meta-analysis

Abstract Background: Cardiovascular complications are strongly correlated with a higher risk of mortality during follow-up after noncardiac surgery. However, controversy remains regarding whether perioperative administration of hydroxymethylglutaryl-CoA reductase inhibitors (statins) has a beneficial effect on patient outcomes. Objective: We performed a meta-analysis to validate the hypothesis that perioperative statins improve patient outcomes after noncardiac surgery. Methods: Electronic databases (PubMed, Web of Science, EMBASE, and the Cochrane Library) were searched for randomized controlled trials (RCTs) published up to 10 November 2017. RCTs were eligible for inclusion if they compared perioperative statin treatment with control treatment in patients scheduled for noncardiac surgery and reported data pertaining to clinical outcomes. Results: Twelve RCTs involving 4707 patients (2371 in the perioperative statin group and 2336 in the control group) were ultimately included in this meta-analysis. The incidences of postoperative myocardial infarction, composite of death/myocardial infarction/stroke and new cases of atrial fibrillation were all lower in patients treated with statins than in control group patients, as shown by the fixed-effects model (odds ratio (OR) = 0.460, 95% confidence interval (CI) = 0.324–0.653, p = 0 for myocardial infarction; OR = 0.617, 95% CI = 0.476–0.801, p = 0 for composite of death/myocardial infarction/stroke; OR = 0.406, 95% CI = 0.247–0.666, p = 0 for new atrial fibrillation). No significant differences in the incidences of stroke or transient ischemic attack, all-cause mortality and cardiovascular mortality were observed between the statin and control arms. Conclusions: This meta-analysis supports the hypothesis that perioperative statins effectively reduce the incidences of postoperative myocardial infarction, composite of death/myocardial infarction/stroke and new cases of atrial fibrillation in patients undergoing noncardiac surgery. Key Messages Cardiovascular complications are strongly correlated with a higher risk of mortality during follow-up after noncardiac surgery. We performed a meta-analysis to confirm the hypothesis that perioperative statins improve patient outcomes after noncardiac surgery.
Chapter 10-Epigenetic Biomarkers of Disease

There is a basic need in medical science to assess the medical state of an individual. Doctors for millennia have practiced this principle including Greek doctors more than 2000 years ago that followed the teachings of Hippocrates of Cos [1]. Hippocratic textbooks advised doctors to examine their patient for “signs” to assist clinical decision making [2]. The principle of measuring a feature indicative of medical state to assist clinical decision making still forms a central role of current health services worldwide. The “measurable feature” is now referred to as a biomarker. The term biomarker has been defined several times in the scientific literature as reviewed by Strimbu and Tavel [3], who have suggested the following as a definition of a biomarker: “The term ‘biomarker,’ a portmanteau of ‘biological marker,’ refers to a broad subcategory of medical signs – that is, objective indications of medical state observed from outside the patient—which can be measured accurately and reproducibly” [3]. This definition of a biomarker will be assumed for the purpose of this discussion. Biomarkers are used routinely in a clinical setting to assess the medical state of patients and in several other medical contexts, including clinical trial endpoints, pharmaceutical development, and basic science research. A clinical example of a biomarker is plasma glucose. The World Health Organization (WHO) published its current diagnostic criteria for diabetes mellitus in 2006 using plasma glucose as a biomarker: fasted plasma glucose above 7.0 mmol/L (126 mg/dL) or 2 h post 75 g oral glucose challenge plasma glucose above 11.1 mmol/L (200 mg/dL) [4]. In the United Kingdom, the National Institute for Health and Care Excellence (NICE) recommended the WHO diagnostic criteria in their Type 2 Diabetes: The Management of Type 2 Diabetes guidelines published in 2009, updated in July 2014 [5], and they are currently being recommended for the National Health Service (NHS). Chapter 10
Dry Socket Etiology, Diagnosis, and Clinical Treatment Techniques

Dry socket, also termed fibrinolytic osteitis or alveolar osteitis, is a complication of tooth exodontia. A dry socket lesion is a post-extraction socket that exhibits exposed bone that is not covered by a blood clot or healing epithelium and exists inside or around the perimeter of the socket or alveolus for days after the extraction procedure. This article describes dry socket lesions; reviews the basic clinical techniques of treating different manifestations of dry socket lesions; and shows how microscope level loupe magnification of 6× to 8× or greater, combined with co-axial illumination or a dental operating microscope, facilitate more precise treatment of dry socket lesions. The author examines the scientific validity of the proposed causes of dry socket lesions (such as bacteria, inflammation, fibrinolysis, or traumatic extractions) and the scientific validity of different terminologies used to describe dry socket lesions. This article also presents an alternative model of what causes dry socket lesions, based on evidence from dental literature. Although the clinical techniques for treating dry socket lesions seem empirically correct, more evidence is required to determine the causes of dry socket lesions.
ANNUAL VARIATION IN BACOSIDE CONTENT OF BACOPA MONNIERI (L.) WETTST PLANTS

A study was conducted to evaluate bacoside (expressed as sum of bacoside A3 and A2) production on a monthly basis in net house grown plants of Bacopa monnieri (accession BM001) collected from Jammu region. Bacoside content differed during the course of the whole year. The whole herb is used commercially for extracting the memory enhancing molecule bacosides from the plant. The study significantly points out that the maximum bacoside yield was obtained during August to October (monsoon period) which also coincides with the favourable period for plant growth and would be suitable for plant harvest. Amongst the various individual plant parts, the highest content was recorded in the leaves (6.06 mg g DW) followed by stem (5.13 mg g DW) and least in the roots (3.19 mg g DW).
Robust and accurate decoding of motoneuron behaviour and prediction of the resulting force output

The spinal alpha motoneuron is the only cell in the human CNS whose discharge can be routinely recorded in humans. We have reengineered motor unit collection and decomposition approaches, originally developed in humans, to measure the neural drive to muscle and estimate muscle force generation in the in vivo cat model. Experimental, computational, and predictive approaches are used to demonstrate the validity of this approach across a wide range of modes to activate the motor pool. The utility of this approach is shown through the ability to track individual motor units across trials, allowing for better predictions of muscle force than the electromyography signal, and providing insights in to the stereotypical discharge characteristics in response to synaptic activation of the motor pool. This approach now allows for a direct link between the intracellular data of single motoneurons, the discharge properties of motoneuron populations, and muscle force generation in the same preparation.
Formyl Peptide Receptor 1 Modulates Endothelial Cell Functions by NADPH Oxidase-Dependent VEGFR2 Transactivation

In the vasculature, NADPH oxidase is the main contributor of reactive oxygen species (ROS) which play a key role in endothelial signalling and functions. We demonstrate that ECV304 cells express p47phox, p67phox, and p22phox subunits of NADPH oxidase, as well as formyl peptide receptors 1 and 3 (FPR1/3), which are members of the GPCR family. By RT-PCR, we also detected Flt-1 and Flk-1/KDR in these cells. Stimulation of FPR1 by N-fMLP induces p47phox phosphorylation, which is the crucial event for NADPH oxidase-dependent superoxide production. Transphosphorylation of RTKs by GPCRs is a biological mechanism through which the information exchange is amplified throughout the cell. ROS act as signalling intermediates in the transactivation mechanism. We show that N-fMLP stimulation induces the phosphorylation of cytosolic Y951, Y996, and Y1175 residues of VEGFR2, which constitute the anchoring sites for signalling molecules. These, in turn, activate PI3K/Akt and PLC-γ1/PKC intracellular pathways. FPR1-induced ROS production plays a critical role in this cross-talk mechanism. In fact, inhibition of FPR1 and/or NADPH oxidase functions prevents VEGFR2 transactivation and the triggering of the downstream signalling cascades. N-fMLP stimulation also ameliorates cellular migration and capillary-like network formation ability of ECV304 cells.
Lexical access in the second year: a study of monolingual and bilingual vocabulary development

It is well established that vocabulary size is related to efficiency in auditory processing, such that children with larger vocabularies recognize words faster than children with smaller vocabularies. The present study evaluates whether this relation is specific to the language being assessed, or related to general language or cognitive processes. Speed of word processing was measured longitudinally in Spanish- and English-learning monolinguals and bilinguals at 16 and 22 months of age. Speed of processing in bilinguals was similar to monolinguals, suggesting that the number of languages to which children are exposed does not influence word recognition. Further, cross-language associations in bilinguals suggest that the dominant language supports processing in the non-dominant language. These cross-language associations are consistent with general language and cognitive efficiency accounts in which the relation between word processing and knowledge relies on experience within a language as well as on general and cognitive properties of language learning.
An Energy-Efficient and Distributed Cooperation Mechanism for k-Coverage Hole Detection and Healing in WSNs

Present approaches to achieve k-coverage for Wireless Sensor Networks still rely on centralized techniques. In this paper, we devise a distributed method for this problem, namely Distributed VOronoi based Cooperation scheme (DVOC), where nodes cooperate in hole detection and recovery. In previous Voronoi based schemes, each node only monitors its own critical points. Such methods are inefficient for k-coverage because the critical points are far away from their generating nodes in k-order Voronoi diagram, causing high cost for transmission and computing. As a solution, DVOC enables nodes to monitor others' critical points around themselves by building local Voronoi diagrams (LVDs). Further, DVOC constrains the movement of every node to avoid generating new holes. If a node cannot reach its destination due to the constraint, its hole healing responsibility will fall to other cooperating nodes. The experimental results from the real world testbed demonstrate that DVOC outperforms the previous schemes.
The impact of radiology expertise upon the localization of subtle pulmonary lesions

Rationale and objectives: This study investigates the influence of radiology expertise in the correct localization of lesions when radiologists are requested to complete an observer task. Specifically, the ability to detect pulmonary lesions of different subtleties is explored in relation to radiologists’ reported specialty. Materials and Methods: Institutional ethics was granted. Ten radiologists (5 thoracic, 5 non-thoracic) interpreted 40 posterior-anterior (PA) chest x-rays (CXRs) consisting of 21 normal and 19 abnormal cases (solitary pulmonary nodule). The abnormal cases contained a solitary nodule with an established subtlety (subtlety 5 = obvious to subtlety 1 = extremely subtle). Radiologists read the test set and identified any pulmonary nodule using a 1-5 confidence scale (1=no pulmonary nodule to 5=highest confidence case contains a pulmonary lesion). The radiologists interpreted the image bank twice and the cases were randomized for each reader between reads. Results: The Kruskal-Wallis test identified that subtlety of nodules significantly influenced the sensitivity of nonthoracic radiologists (P=<0.0001) and thoracic radiologists (P=<0.0001). A Wilcoxon rank test demonstrated a significant difference in sensitivity for radiologist specialisation (P=0.013), with thoracic radiologists better compared to non-thoracic radiologists (mean sensitivity 0.479 and 0.389 respectively). The sensitivity of nodule detection decreased when comparing subtlety 4 to 3, 3 to 2 and 2 to 1 for non-thoracic and thoracic radiologists’with the subtlety 3 to subtlety 2 being significant (P=0.014) for non thoracic radiologists while thoracic radiologists’ demonstrated a decrease but no transitions between subtlety were significant. The most noticeable, and interesting, effect was with the thoracic radiologists’ with the average means of subtlety 2 and 1 being almost the same and closely comparable to level 3. Conclusion: Results from this study indicate that expertise in chest radiology does significantly impact upon the sensitivity of radiologists in detecting pulmonary lesions of varying subtlety. Thoracic radiologists had a consistently higher sensitivity with subtle, very subtle and extremely subtle nodules.
Implications of life-history strategies for obesity

Significance The prevalence of obesity reflects a major public health challenge in the United States and many other parts of the world. The current studies adopt a life history theory (LHT) perspective to explain in part the root causes of obesity. This research identifies exposure to unpredictable environments during childhood as a distal factor that contributes to obesity in adulthood. Exposure to childhood unpredictability is linked to the development of a fast life-history strategy, one marked by impulsivity and a focus on short-term goals. LHT provides a valuable conceptual framework for understanding the behavioral mechanisms that underlie dysregulated patterns of eating and, ultimately, the development of weight-management problems in adulthood. This research also provides insight into pathways for obesity prevention. The association between low socioeconomic status (SES) and obesity is well documented. In the current research, a life history theory (LHT) framework provided an explanation for this association. Derived from evolutionary behavioral science, LHT emphasizes how variability in exposure to unpredictability during childhood gives rise to individual differences in a range of social psychological processes across the life course. Consistent with previous LHT research, the current findings suggest that exposure to unpredictability during childhood (a characteristic common to low SES environments) is associated with the adoption of a fast life-history strategy, one marked by impulsivity and a focus on short-term goals. We demonstrate that a fast life-history strategy, in turn, was associated with dysregulated weight-management behaviors (i.e., eating even in the absence of hunger), which were predictive of having a high body mass index (BMI) and being obese. In both studies, findings held while controlling for participants’ current socioeconomic status, suggesting that obesity is rooted in childhood experiences. A serial mediation model in study 2 confirmed that effects of childhood SES on adult BMI and obesity can be explained in part by exposure to unpredictability, the adoption of a fast life-history strategy, and dysregulated-eating behaviors. These findings suggest that weight problems in adulthood may be rooted partially in early childhood exposure to unpredictable events and environments. LHT provides a valuable explanatory framework for understanding the root causes of obesity.
A Reinforced Topic-Aware Convolutional Sequence-to-Sequence Model for Abstractive Text Summarization

In this paper, we propose a deep learning approach to tackle the automatic summarization tasks by incorporating topic information into the convolutional sequence-to-sequence (ConvS2S) model and using self-critical sequence training (SCST) for optimization. Through jointly attending to topics and word-level alignment, our approach can improve coherence, diversity, and informativeness of generated summaries via a biased probability generation mechanism. On the other hand, reinforcement training, like SCST, directly optimizes the proposed model with respect to the non-differentiable metric ROUGE, which also avoids the exposure bias during inference. We carry out the experimental evaluation with state-of-the-art methods over the Gigaword, DUC-2004, and LCSTS datasets. The empirical results demonstrate the superiority of our proposed method in the abstractive summarization.
Ultrafast frequency-agile terahertz devices using methylammonium lead halide perovskites

We demonstrate new capabilities for frequency-agile terahertz devices using perovskites. The ability to control the response of metamaterial structures can facilitate the development of new terahertz devices, with applications in spectroscopy and communications. We demonstrate ultrafast frequency-agile terahertz metamaterial devices that enable such a capability, in which multiple perovskites can be patterned in each unit cell with micrometer-scale precision. To accomplish this, we developed a fabrication technique that shields already deposited perovskites from organic solvents, allowing for multiple perovskites to be patterned in close proximity. By doing so, we demonstrate tuning of the terahertz resonant response that is based not only on the optical pump fluence but also on the optical wavelength. Because polycrystalline perovskites have subnanosecond photocarrier recombination lifetimes, switching between resonances can occur on an ultrafast time scale. The use of multiple perovskites allows for new functionalities that are not possible using a single semiconducting material. For example, by patterning one perovskite in the gaps of split-ring resonators and bringing a uniform thin film of a second perovskite in close proximity, we demonstrate tuning of the resonant response using one optical wavelength and suppression of the resonance using a different optical wavelength. This general approach offers new capabilities for creating tunable terahertz devices.
Elephants in the understory: opposing direct and indirect effects of consumption and ecosystem engineering by megaherbivores.

Positive indirect effects of consumers on their resources can stabilize food webs by preventing overexploitation, but the coupling of trophic and non-trophic interactions remains poorly integrated into our understanding of community dynamics. Elephants engineer African savanna ecosystems by toppling trees and breaking branches, and although their negative effects on trees are well documented, their effects on small-statured plants remain poorly understood. Using data on 117 understory plant taxa collected over 7 yr within 36 1-ha experimental plots in a semi-arid Kenyan savanna, we measured the strength and direction of elephant impacts on understory vegetation. We found that elephants had neutral effects on most (83-89%) species, with a similar frequency of positive and negative responses among the remainder. Overall, estimated understory biomass was 5-14% greater in the presence of elephants across a range of rainfall levels. Whereas direct consumption likely accounts for the negative effects, positive effects are presumably indirect. We hypothesized that elephants create associational refuges for understory plants by damaging tree canopies in ways that physically inhibit feeding by other large herbivores. As predicted, understory biomass and species richness beneath elephant-damaged trees were 55% and 21% greater, respectively, than under undamaged trees. Experimentally simulated elephant damage increased understory biomass by 37% and species richness by 49% after 1 yr. Conversely, experimentally removing elephant damaged branches decreased understory biomass by 39% and richness by 30% relative to sham-manipulated trees. Camera-trap surveys revealed that elephant damage reduced the frequency of herbivory by 71%, whereas we detected no significant effect of damage on temperature, light, or soil moisture. We conclude that elephants locally facilitate understory plants by creating refuges from herbivory, which countervails the direct negative effects of consumption and enhances larger-scale biomass and diversity by promoting the persistence of rare and palatable species. Our results offer a counterpoint to concerns about the deleterious impacts of elephant "overpopulation" that should be considered in debates over wildlife management in African protected areas: understory species comprise the bulk of savanna plant biodiversity, and their responses to elephants are buffered by the interplay of opposing consumptive and non-consumptive interactions.
Free Gingival Graft versus Mucograft: Histological Evaluation

INTRODUCTION: The correction of the gingival recession is of esthetical and functional significance, but the tissue regeneration can only be confirmed by a histological examination. AIM: This study aims to make a comparison between the free gingival graft and the autograft. MATERIAL AND METHODS: This study included 24 patients with single and multiple gingival recessions. Twelve patients were treated with a free gingival graft and the other twelve with a micrograft. Six months after the surgical procedure, a micro-punch biopsy of the transplantation area was performed. The tissue was histologically evaluated, graded in 4 categories: immature, mature, fragmented and edematous collagen tissue. The elastic fibres were also examined and graded in three categories: with a normal structure, fragmented rare and fragmented multiplied. RESULTS: Regarding the type of collagen tissue that was present, there was a significant difference between the two groups of patients, with a larger number of patients treated with a micrograft showing a presence of mature tissue, compared to the patients treated with a free gingival graft. A larger number of patients in both of the groups displayed elastic fibres with a rare fragmented structure; 33.3% of the patients showed a normal structure; 50% demonstrated a normal structure. CONCLUSION: The patients treated with a free gingival graft showed a larger presence of fragmented collagen tissue and fragmented elastic fibres, whereas a mature tissue was predominantly present in the surgical area where a Geistlich Mucograft was placed.
RowClone: Accelerating Data Movement and Initialization Using DRAM

In existing systems, to perform any bulk data movement operation (copy or initialization), the data has to first be read into the on-chip processor, all the way into the L1 cache, and the result of the operation must be written back to main memory. This is despite the fact that these operations do not involve any actual computation. RowClone exploits the organization and operation of commodity DRAM to perform these operations completely inside DRAM using two mechanisms. The first mechanism, Fast Parallel Mode, copies data between two rows inside the same DRAM subarray by issuing back-to-back activate commands to the source and the destination row. The second mechanism, Pipelined Serial Mode, transfers cache lines between two banks using the shared internal bus. RowClone significantly reduces the raw latency and energy consumption of bulk data copy and initialization. This reduction directly translates to improvement in performance and energy efficiency of systems running copy or initialization-intensive workloads