Miracle-dz/UniFAR-FTUs huggingface dataset:
Do Traditional Financial Distress Prediction Models Predict the Early Warning Signs of Financial Distress?

Purpose: This study aims to compare the prediction accuracy of traditional distress prediction models for the firms which are at an early and advanced stage of distress in an emerging market, Pakistan, during 2001–2015. Design/methodology/approach: The methodology involves constructing model scores for financially distressed and stable firms and then comparing the prediction accuracy of the models with the original position. In addition to the testing for the whole sample period, comparison of the accuracy of the distress prediction models before, during, and after the financial crisis was also done. Findings: The results indicate that the three-variable probit model has the highest overall prediction accuracy for our sample, while the Z-score model more accurately predicts insolvency for both types of firms, i.e., those that are at an early stage as well as those that are at an advanced stage of financial distress. Furthermore, the study concludes that the predictive ability of all the traditional financial distress prediction models declines during the period of the financial crisis. Originality/value: An important contribution is the widening of the definition of financially distressed firms to consider the early warning signs related to failure in dividend/bonus declaration, quotation of face value, annual general meeting, and listing fee. Further, the results suggest that there is a need to develop a model by identifying variables which will have a higher impact on the financial distress of firms operating in both developed and developing markets.
Gate Stack Reliability of MOSFETs With High-Mobility Channel Materials: Bias Temperature Instability

To sustain the historical trend of performance enhancement of metal-oxide-semiconductor field-effect transistors (MOSFETs) for high-performance and low-power logic applications beyond the 10-nm technology node, InGaAs and Ge or GeSn are promising alternative channel materials to replace strained Si due to their high electron and hole mobility values, respectively. In addition to delivering higher drive current at a reduced supply voltage VDD, another challenge in integrating these materials is to achieve device lifetimes equal or better than that of the Si counterpart. In this paper, we report the results of bias temperature instability (BTI) investigations on InGaAs n-channel MOSFETs (nMOSFETs) and GeSn p-channel MOSFETs (pMOSFETs) with a common surface passivation and gate stack formation technology. While GeSn planar pMOSFETs with Si passivation show excellent negative bias temperature instability (NBTI) reliability, positive bias temperature instability (PBTI) reliability of InGaAs nMOSFETs needs further improvement. The strain effect on NBTI of Ge pMOSFETs will be discussed. The NBTI of Ge multiple-gate field-effect transistors (MuGFETs) will be also reported. In addition, we review the status of the BTI reliability for MOSFETs with high-mobility channel materials and discuss issues of BTI characterization of transistors with small bandgap channel materials and the importance of interface quality between channel materials and gate dielectrics for device BTI performance.
Role of Vascular Endothelial Growth Factor in Blood‐Brain Barrier Breakdown and Angiogenesis in Brain Trauma

The role of vascular endothelial growth factor (VEGF) in blood-brain barrier (BBB) breakdown and angiogenesis, observed previously in the cerebral cortical cold-injury model, was investigated. Immunohistochemistry was used to assess BBB permeability to plasma fibronectin and to localize VEGF protein in the cortical cold-injury model over a period of 10 min to 14 days post-injury. BBB breakdown to fibronectin in lesion vessels was observed at 10 min post-injury, was maximal between 2 and 4 days and declined gradually thereafter, while occasional perilesional vessels remained permeable up to 6 days. Increased VEGF immunoreactivity occurred later— it was observed in pial vessels after 6 hours (h), and persisted up to day 14. Arterioles within the cold lesion showed VEGF immunoreactivity at 36 h, thus preceding the onset of endothelial proliferation and angiogenesis that occurred from day 3 to day 5. VEGF immunoreactivity was also observed in inflammatory cells and astrocytes. These results indicate that the immediate breakdown of the BBB in the cold lesion is unrelated to VEGF. The presence of mural VEGF in permeable pial vessels and lesional arterioles suggests that VEGF is one of several factors that mediates BBB breakdown in this model. The association of maximal VEGF immunoreactivity with endothelial proliferation and neovascularization suggests that VEGF promotes angiogenesis and repair following brain trauma.
Fast Psychomotor Functioning in Anorexia Nervosa: Effect of Weight Restoration

In a previous study young seriously underweight anorexia nervosa (AN) patients in the early phase of treatment were found to react faster in psychomotor tasks. To further understand this finding we studied the impact of weight restoration on the performance of AN patients in drawing and copying tasks. A group of 17 female AN patients, aged 14 to 25, was compared with 17 healthy controls, matched for sex, age and educational level. Patients were tested when severely underweight and after weight restoration. Control subjects were also tested twice. Using computerized recording and analysis of writing and drawing behavior, reaction times and drawing times were derived, while cognitive and motor demands were manipulated. Overall, AN patients showed shorter reaction times in copying tasks and shorter drawing time in the drawing task than normal controls, and this pattern persisted after weight restoration. No significant group (AN vs. controls) by session (test vs. retest) effect emerged. The finding of a consistent pattern of shorter reaction and drawing times in AN patients before and after weight restoration is compatible with a personality characteristic of perfectionism and overachievement in AN patients. The authors would like to thank Leen Gielen for her help in applying the tests and preparing the data.
Telomere length in peripheral blood cells of germline TP53 mutation carriers is shorter than that of normal individuals of corresponding age

A decrease in the age at cancer onset and increase in cancer incidence in successive generations in Li‐Fraumeni syndrome (LFS) families with germline TP53 mutations have been previously described. In the current study a possible relation was analyzed between telomere length and cancer onset in TP53 mutation carriers.
Dynamic magnetic susceptibility and electrical detection of ferromagnetic resonance

The dynamic magnetic susceptibility of magnetic materials near ferromagnetic resonance (FMR) is very important in interpreting the dc voltage obtained in its electrical detection. Based on the causality principle and the assumption that the usual microwave absorption lineshape of a homogeneous magnetic material around FMR is Lorentzian, the general forms of the dynamic magnetic susceptibility of an arbitrary sample and the corresponding dc voltage lineshapes of its electrical detection were obtained. Our main findings are as follows. (1) The dynamic magnetic susceptibility is not a Polder tensor for a material with an arbitrary magnetic anisotropy. The two off-diagonal matrix elements of the tensor near FMR are not, in general, opposite to each other. However, the linear response coefficient of the magnetization to the total radio frequency (rf) field (the sum of the external and internal rf fields due to precessing magnetization is a quantity which cannot be measured directly) is a Polder tensor. This may explain why the two off-diagonal susceptibility matrix elements were always wrongly assumed to be opposite to each other in almost all analyses. (2) The frequency dependence of dynamic magnetic susceptibility near FMR is fully characterized by six real numbers, while its field dependence is fully characterized by seven real numbers. (3) A recipe of how to determine these numbers by standard microwave absorption measurements for a sample with an arbitrary magnetic anisotropy is proposed. Our results allow one to unambiguously separate the contribution of the anisotropic magnetoresistance to the dc voltage signals from the anomalous Hall effect. With these results, one can reliably extract the information of spin pumping and the inverse spin-Hall effect, and determine the spin-Hall angle. (4) In the case that resonance frequency is not sensitive to the applied static magnetic field, the field dependence of the matrix elements of dynamic magnetic susceptibility, as well as the dc voltage, may have another non-resonance broad peak. Thus, one should be careful in interpreting the observed peaks.
Study on the Monotonicity of Bending Loss of Polymer Optical Fiber

Bending loss of polymer optical fibers (POFs) shows unexpected oscillatory behaviors due to the interference between whispering gallery mode and core mode for the cases of small bending radius and large bending angle. We have found a novel method of suppressing the oscillatory behavior of bending loss of POFs. By partially removing the cladding and core, the bending loss monotonicity with improved linearity was obtained for POFs with small bending radius in a large range of bending angles for the first time. This method is useful in the application of extreme large strain (e.g., ≥60%) sensors of POF.
Region-Based Image Retrieval Revisited

Region-based image retrieval (RBIR) technique is revisited. In early attempts at RBIR in the late 90s, researchers found many ways to specify region-based queries and spatial relationships; however, the way to characterize the regions, such as by using color histograms, were very poor at that time. Here, we revisit RBIR by incorporating semantic specification of objects and intuitive specification of spatial relationships. Our contributions are the following. First, to support multiple aspects of semantic object specification (category, instance, and attribute), we propose a multitask CNN feature that allows us to use deep learning technique and to jointly handle multi-aspect object specification. Second, to help users specify spatial relationships among objects in an intuitive way, we propose recommendation techniques of spatial relationships. In particular, by mining the search results, a system can recommend feasible spatial relationships among the objects. The system also can recommend likely spatial relationships by assigned object category names based on language prior. Moreover, object-level inverted indexing supports very fast shortlist generation, and re-ranking based on spatial constraints provides users with instant RBIR experiences.
Active oxygen generation as a possible mechanism of selenium toxicity.

Selenium plays an important role in scavenging active oxygen (AO) species as an essential constituent of glutathione peroxidase. On the other hand, several reports proposed a possible induction of toxic AO by selenium compounds in vitro. However, some of these experiments including ours, were revealed to conclude on the basis of experimental artifacts, and to have problems in the interpretation of data. Methods or principles so far used for the detection of AO species generated by selenium compound were measurement of chemiluminescence from lucigenin or luminol by AO species, the spectrophotometric analysis of reduction of ferricytochrome c or nitroblue tetrazolium (NBT) by superoxide anion (O2-), electron spin resonance (ESR) spectra using dimethylpyrroline oxide (DMPO) as a spin trapping agent, the deoxyribose decomposition by hydroxyl radical (HO.), the salicylate hydroxylation by HO. , and the strand breakage of DNA by AO. Many of these methods together with their principles seem to have some defects which prevent clear conclusion as stated below. (i) Lucigenin was found to mediate the formation of O2- in the presence of selenite and reduced glutathione (GSH). Therefore, lucigenin is not a suitable reagent. (ii) Luminol may also mediate O2- generation in the presence of HO. (iii) ferricytochrome c can be reduced to ferrocytochrome c in the mixture of selenite and GSH in the absence of oxygen. Moreover, the spectrophotometric method is interfered by turbidity of elemental selenium formed under some conditions in the reaction mixture containing selenite and GSH. (iv) NBT is also reduced by selenium compounds in the absence of O2. (v) ESR signals of AO species were obtained in the reaction mixture containing selenite and GSH, or in the solution of hydrogen selenide in the presence of O2. However, selenide decomposed spin adduct of DMPO with HO. (DMPO-OH). Therefore, the intensity of the signals is not quantitative. (vi) CuZn-SOD is not necessarily a good tool to prove the involvement of O2- because it enhanced HO. generation in the reaction mixture containing selenite and GSH. Thus, we would like to emphasize that carefully designed experiments are required to further identify the molecular species of active oxygen induced by selenium compounds.
Cloning, expression, purification, and characterization of the acid alpha-mannosidase from Trypanosoma cruzi.

The acid alpha-mannosidase of Trypanosoma cruzi is a broad-specificity hydrolase involved in the catabolism of glycoconjugates, presumably in the digestive vacuole. We have cloned the alpha-mannosidase gene from a T.cruzi epimastigote genomic library. The alpha-mannosidase gene was determined to be single copy by Southern analysis, and similar sequences were not detected in genomic digests of either Trypanosoma brucei or Leishmania donovani. The coding region was subcloned into the Pichia pastoris expression vector pPICZ, and alpha-mannosidase activity was detected in the medium of induced cultures. The recombinant alpha-mannosidase demonstrated a pH optimum, inhibition by swainsonine, Km, and substrate specificity consistent with the characteristics of the alpha-mannosidase previously purified from T.cruzi epimastigotes. The recombinant enzyme was purified 103-fold from the culture medium of Pichia pastoris and had a native molecular mass of 359 kDa by gel filtration. A combination of SDS-PAGE, deglycosylation with endo H, and NH2-terminal sequencing indicates that the enzyme is originally synthesized as a homodimeric polypeptide that is subsequently cleaved to form a heterotetramer composed of 57 and 46 kDa subunits. A polyclonal antibody raised to the recombinant enzyme was shown to immunoprecipitate the alpha-mannosidase from T.cruzi cell extracts and will be used in future immunolocalization studies.
MAINSTREAMING STRATEGIES AND GENDER EQUALITY IN DODOMA MUNICIPALITY AND MPWAPWA DISTRICT COUNCIL, TANZANIA

Gender equality within Local Government Authorities (LGAs) is an important aspect for spearheading sustainable development in any country. Gender Mainstreaming Strategies (GMSs) are set to achieve Gender equality. Despite various GMSs, gender gaps and their negative impacts to sustainable development persist in Tanzania. This can be attributed to various challenges in the course of implementing GMSs. However, in Tanzania, few studies have uncovered levels of gender equality as a result of GM in LGAs. Likewise, the data for challenges which may be impeding the implementation of various GMSs are scarce. Hence, this paper is about (i) assessing some implemented GMSs (ii) determining challenges encountered in mainstreaming gender, (iii) examining the levels of gender equality achieved in the LGAs as a result of GMSs and (iv) determining gender equality levels of men and women officials in urban and rural areas. A cross-sectional research design was employed using 358 respondents. Levels of gender equality achieved were measured by using a Composite Gender Equality Index (CGEI). The Index was adopted from the European Union Gender Equality Index (GEI) whose measure of Gender Equality (GE) ranges from 1 to 100. The Man Whitney U test was used to test the hypothesis that (i) gender equality levels are the same between male and female officials and also between Dodoma Municipality and Mpwapwa District officials . The results showed that most of GMSs were not well implemented; therefore LGAs planners should make sure that the implementation of existing GMSs is ensured according to government priorities and frameworks . Since, the overall gender equality level was found to be low (34.7% and 24.6% for male and female respectively); hence more gender mainstreaming strategies have to be implemented at the LGA level so as to spearhead sustainable development. Moreover, the equality level was generally found to be the same for both male and female, urban and rural officials , then, policy planners and LGAs gender sensitising bodies such as NGOs, media and CBOs were urged toprovide GM measures targeting both MDC and DMC equally. Since large number of men reported high level of gender equality while the overall level of gender equality was low, then it is recommended that men should be used by policy makers as agents for change towards gender equality as they occupy many decision making positions in LGAs as compared to women .
Expression patterns and action analysis of genes associated with hepatitis virus infection during rat liver regeneration.

AIM To study the action of hepatitis virus infection-associated genes at transcription level during liver regeneration (LR). METHODS Hepatitis virus infection-associated genes were obtained by collecting the data from databases and retrieving the correlated articles, and their expression changes in the regenerating rat liver were detected with the rat genome 230 2.0 array. RESULTS Eighty-eight genes were found to be associated with liver regeneration. The number of genes initially and totally expressed during initial LR [0.5-4 h after partial hepatectomy (PH)], transition from G0 to G1 (4-6 h after PH), cell proliferation (6-66 h after PH), cell differentiation and reorganization of structure-function (66-168 h after PH) was 37, 8, 48, 3 and 37, 26, 80, 57, respectively, indicating that the genes were mainly triggered at the early stage of LR (0.5-4 h after PH), and worked at different phases. These genes were classified into 5 types according to their expression similarity, namely 37 up-regulated, 9 predominantly up-regulated, 34 down-regulated, 6 predominantly down-regulated and 2 up/down-regulated genes. Their total up- and down-regulation frequencies were 359 and 149 during LR, indicating that the expression of most genes was enhanced, while the expression of a small number of genes was attenuated during LR. According to time relevance, they were classified into 12 groups (0.5 and 1 h, 2 and 4 h, 6 h, 8 and 12 h, 16 and 96 h, 18 and 24 h, 30 and 42 h, 36 and 48 h, 54 and 60 h, 66 and 72 h, 120 and 144 h, 168 h), demonstrating that the cellular physiological and biochemical activities during LR were fluctuated. According to expression changes of the genes, their expression patterns were classified into 23 types, suggesting that the cellular physiological and biochemical activities during LR were diverse and complicated. CONCLUSION The anti-virus infection capacity of regenerating liver can be enhanced and 88 genes play an important role in LR.
Approximate entropy of symptoms of mood: an effective technique to quantify regularity of mood.

OBJECTIVES Several psychiatric conditions are associated with lability of affect. In this study, we investigated regularity of mood using APEN (Approximate Entropy) on daily subjective ratings using a Visual Analog Scale with 11 items pertaining to mood. METHODS APEN was applied to the data in a double-blind placebo controlled investigation on the effects of fluoxetine (n=19), pemoline (n=18) and placebo (n=20) in normal controls. These subjects rated their subjective feelings daily at the end of each day. We analysed 56 data point time series (each value was obtained on each day) after the three experimental conditions. RESULTS While the mean or the SD of all the 56 points was not significantly different among the three conditions, APEN was highly and significantly lower for pemoline compared with fluoxetine and placebo. There was no significant correlation between average APEN and mean or SD (standard deviation). The one symptom that explained most of this difference among the groups after drug administration was the feeling of 'happiness'. CONCLUSIONS This result indicates that there was a more consistent subjective sense of happiness during the 8-week period of pemoline administration compared with the other two drugs. Though this study was not designed to address the efficacy of mood stabilizing drugs, such daily subjective ratings may be useful in future studies that evaluate the stability of mood. APEN has been used in several different fields of research with small data sets and this study extends its possible use to evaluate changes in mood in certain populations such as patients with bipolar disorders.
Evidence that autoimmunity in man is a Mendelian dominant trait.

Family studies of autoimmune diseases are consistent with multifactorial etiology. However, familial occurrence of the autoimmune trait as defined by the presence of autoimmune disease and/or high titer autoantibody supports the hypothesis that autoimmunity is inherited as an autosomal dominant trait. Based on genetic analysis of 18 autoimmune kindreds, the population frequency of this primary autoimmune gene is approximately . 10 with penetrance estimates of 92% in females and 49% in males. The estimated high penetrance of the autoimmune gene in females suggests that the interacting genetic and/or environmental factors must be numerous or ubiquitous. Sex, age, and specific major histocompatibility complex (MHC) antigens are among the genetic and physiological factors known to influence autoimmunity. A genetic model is proposed that takes these factors into account. Inherent in the hypothesis of a primary autoimmune gene is that it is epistatic to other, secondary, genes that influence the autoimmune phenotype. The genetic model further postulates that the secondary genes, including those of the MHC, confer specificity to the phenotype. The effects of the secondary genes can be modulated by gonadal steroids and, over time, may be abrogated by environmental challenges, such as viral infections.
A low-power 18-GHz dual-injection-locked frequency divider in 65-nm CMOS

In this paper, an 18-GHz dual-injection locked frequency divider (ILFD) is presented. In order to decrease the complexity of PLL design, the dual-ILFD doesn't adopt a frequency adjustment scheme but achieves a large locking range due to fully utilizing the voltage and current injection of the input signal. This ILFD is implemented in SMIC 65nm CMOS technology and consumes 1.8mW from a 1.2V voltage supply excluding buffers and biasing circuits. The core area is 0.35mm× 0.73mm. The measured locking range is 13.3GHz~18.4GHz with 0dBm input power.
STED super-resolution microscopy in Drosophila tissue and in mammalian cells

Far-field super-resolution microscopy is a rapidly emerging method that is opening up opportunities for biological imaging beyond the optical diffraction limit. We have implemented a Stimulated Emission Depletion (STED) microscope to image single dye, cell, and tissue samples with 50-80 nm resolution. First, we compare the STED performance imaging single molecules of several common dyes and report a novel STED dye. Then we apply STED to image planar cell polarity protein complexes in intact fixed Drosophila tissue for the first time. Finally, we present a preliminary study of the centrosomal protein Cep164 in mammalian cells. Our images suggest that Cep164 is arranged in a nine-fold symmetric pattern around the centriole, consistent with findings suggested by cryoelectron tomography. Our work demonstrates that STED microscopy can be used for superresolution imaging in intact tissue and provides ultrastructural information in biological samples as an alternative to immuno-electron microscopy.