Miracle-dz/UniFAR-FTUs huggingface dataset:
Une stratégie multiparamétrique basée sur la Proper Generalized Decomposition

Les campagnes d’optimisation, qui sont de plus en plus frequentes, impliquent de mener un grand nombre d’etudes parametriques, ce qui peut rendre ainsi la demarche tres couteuse en temps de calcul. On se propose ici de developper une strategie dite multiparametrique afin de reduire ces temps de calculs. On utilise pour cela la methode LATIN associee a la Proper Generalized Decomposition (PGD). Cette strategie sera comparee a d’autres couramment utilisees se basant, notamment, sur la POD.
Prostate cancer‐specific mortality and the extent of therapy in healthy elderly men with high‐risk prostate cancer

The risk of prostate cancer‐specific mortality (PCSM) in healthy elderly men may depend on extent of treatment. The authors of this report compared the use of brachytherapy alone with combined brachytherapy, external‐beam radiation to the prostate and seminal vesicles, and androgen‐suppression therapy (CMT) in this population.
Promoting physical activity in a multi-ethnic district - methods and baseline results of a pseudo-experimental intervention study

Background and design A combined community and high-risk intervention study of three years duration started in one district in Oslo after a baseline health survey in two multi-ethnic and low socio-economic status (SES) districts, using a pseudo-experimental design with an age-matched sample from the other district as controls. The intervention focused on promoting physical activity to reduce the burden of type 2 diabetes and cardiovascular disease (CVD). Methods A total of 6140 subjects were invited to participate (age group: 31-67). Data on health status and health-related behaviours, collected via standardized questionnaires, physical examinations and blood sample analyses, were available for 2950 persons (attendance rate 48%), whereas official statistics were available for the invited population. Results The prevalence of self-reported diabetes was 5.1% in men and 3.5% in women, but the total diabetes prevalence was 9% for men and 5.1% for women. One-third of the population were sedentary in their leisure time, men more than women (38% versus 29%). The prevalence of obesity did not differ between the genders (21% had BMI 30 kg/m2). The relatively high mean scores on most psychosocial variables related to physical activity, especially among women, indicate a high motivational readiness for increase in physical activity behaviour. The baseline data, for example on the prevalence of chronic diseases were similar in the two districts. Conclusion The prevalence of self-reported diabetes is remarkably higher than reported from other studies in Norway. The proportion of undiagnosed diabetes was higher than anticipated, and constituted 39% of all those categorized as diabetics.
Iris categorization with texton representation

A key concern with iris recognition systems is the time required to reliably find a test sample's match in a large database of subjects. This work considers methods for categorizing irises within a database, so that a search for a match to a test sample can be focused on the test sample's category. This work uses texton learning to reduce the representation of the images and then clusters the images with the unsupervised k-means technique. Success of the system is assessed as its ability to consistently classify images from the same subject. This work includes experiments to determine the optimal number of textons and image clusters. It also investigates different accuracy metrics and analyzes the potential time saving impacts for finding a database match.
Compensation of rotor position estimation error due to stator winding resistance in signal injection based sensor less PMSM drives

Signal injection techniques are popular to extract rotor position information from low speed to stand still, however these techniques have error in rotor position estimation. In the literature estimated rotor position information neglect the stator winding resistance; this work analyzes the stator winding resistance effect on position estimation accuracy and proposes compensation technique to reduce the position estimation error introduced by stator winding resistance. Proposed compensation technique is validated by simulation results. This work also analyzes the position estimation error resulting from neglecting stator winding resistance and torque reduction.
Treatment outcomes of midfacial segment pain: experience from the Liverpool multi-disciplinary team facial pain clinic.

OBJECTIVES Midfacial segment pain (MSP) has the characteristics of tension-type headache which is confined to the midface cor- responding to the second division of the trigeminal nerve. This review presents treatment outcomes of MSP patients managed at the Multi-disciplinary Team (MDT) Facial Pain Clinic in Liverpool. METHODOLOGY Prospective clinical outcome performed in a tertiary referral centre for complex facial pain syndromes. MAIN OUTCOME MEASURES Sino-Nasal Outcome Test (SNOT). Clinical "success" was defined as an improvement in total SNOT score of >9 points and a reduction of the ear-facial symptoms sub-domain score by ≥50% from baseline. RESULTS The average age of the cohort was 49 years, with an average follow-up of 12 months. The overall pre-treatment total SNOT-22 score was 59.5 which improved significantly to 42 at latest follow-up. Although the average scores of all sub-domains improved, only the ear-facial symptoms and psychological issues sub-domains achieved statistical significance. When the criterion for success was applied, nine patients fulfilled this definition at an average of 12 months follow-up. The baseline total SNOT score in this cohort improved from 60.6 to 19.7. Half of these patients achieved success within 18 months of commencing treatment and the probability of attaining success at long-term follow-up was high. CONCLUSIONS Treatment of midfacial segment facial pain is complex and requires follow-up to achieve any meaningful clinical outcome.
Using Queuing Approach for Locating the Order Penetration Point in a Two-Echelon Supply Chain with Customer Loss

An order penetration point (OPP) is the boundary between make-to-order (MTO) policy and make-to-stock (MTS) policy. This study is dedicated to OPP strategic decision making which is concerned with the upstream and downstream decisions of OPP in supply chains. In this paper, we consider a two-echelon production supply chain in which in first production stage, supplier manufactures the semi-finished products on a MTS policy for a manufacturer in second production stage that will customize the products on a MTO policy. The manufacturer desires to find the optimal fraction of processing time fulfilled by its supplier and its optimal semi-finished products buffer storage capacity in OPP. Also, impatient customers are considered in the study. In order to calculate system performance indexes, we employ matrix geometric method and queuing steady state equations. Afterward, optimal solutions are obtained applying an optimization mathematical model with enumeration and direct search techniques.
Garbage Collector for memory intensive applications on NUMA architectures. (ramasse-miette pour les applications avec forte utilisation de la mémoire sur architectures numa)

Large-scale multicore architectures create new challenges for garbage collectors (GCs). On con-temporary cache-coherent Non-Uniform Memory Access (ccNUMA) architectures, applications with a large memory footprint suffer from the cost of the garbage collector (GC), because, as the GC scans the reference graph, it makes many remote memory accesses, saturating the interconnect between memory nodes. In this thesis, we address this problem with NumaGiC, a GC with a mostly-distributed design. In order to maximise memory access locality during collection, a GC thread avoids accessing a different memory node, instead notifying a remote GC thread with a message; nonetheless, NumaGiC avoids the drawbacks of a pure distributed design, which tends to decrease parallelism and increase memory access imbalance, by allowing threads to steal from other nodes when they are idle. NumaGiC strives to find a perfect balance between local access, memory access balance, and parallelism. In this work, we compare NumaGiC with Parallel Scavenge and some of its incrementally improved variants on two different ccNUMA architectures running on the Hotspot Java Virtual Machine of OpenJDK 7. On Spark and Neo4j, two industry-strength analytics applications, with heap sizes ranging from 160 GB to 350 GB, and on SPECjbb2013 and SPECjbb2005, NumaGiC improves overall performance by up to 94% over Parallel Scavenge, and increases the performance of the collector itself by up to 5.4× over Parallel Scavenge. In terms of scalability of GC throughput with increasing number of NUMA nodes, NumaGiC scales substantially better than Parallel Scavenge for all the applications. In fact in case of SPECjbb2005, where inter-node object references are the least among all, NumaGiC scales almost linearly.
Temporal Regulation of VEID-7-amino-4-trifluoromethylcoumarin Cleavage Activity and Caspase-6 Correlates with Organelle Loss during Lens Development*

Lens fiber cell differentiation involves extensive reconstruction of the cell's architecture, including the degradation and elimination of all membrane-bound organelles via a process that has been likened to apoptosis. Using caspase reporter assays under conditions in which nonspecific cleavage of the reporter peptides by the proteasome has been inhibited, we investigated whether any specific caspase activities are temporally correlated with this process of organelle loss. Extracts from neonatal mouse lenses contained strong VEID-7-amino-4-trifluoromethylcoumarin (AFC) and minor IETD-AFC and LEVD-AFC cleavage activities, but no DEVD-AFC cleavage activity. Further testing suggested that the VEID-AFC and IETD-AFC cleavage activities were likely due to the same enzyme. In lens extracts from rat embryos, VEID-AFC cleavage activity increased during the period when organelles are eliminated, between embryonic days 15.5 and 18.5, whereas procaspase-6 protein levels decreased, suggesting that this enzyme is responsible for VEID-AFC cleavage. By contrast, in extracts from αAE7 transgenic mouse lenses in which apoptosis was induced, strong DEVD-AFC cleavage activity and activated caspase-3 protein were detected. Thus, within the same tissue, different caspase activities can predominate depending on the context, normal differentiation versus apoptosis. These results highlight the difference between normal fiber cell differentiation and apoptosis and the capacity of the lens to differentially regulate these two processes.
Gene Regulation of CYP4F11 in Human Keratinocyte HaCaT Cells

Mechanisms regulating CYP4F genes remain under investigation, although characterization of CYP4F regulatory modalities would facilitate the discovery of new drug targets. This present study shows that all-trans- and 9-cis-retinoic acids can inhibit CYP4F11 expression in human keratinocyte-derived HaCaT cells. Transrepression of many genes by retinoic acids is mediated by interactions between retinoid receptors and the activator protein 1 (AP-1) complex. Proinflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin 1β, which can activate the AP-1 complex, induce CYP4F11 transcription in HaCaT cells. The c-Jun N-terminal kinase (JNK)-specific inhibitor 1,9-pyrazoloanthrone (SP600125) blocked the induction of CYP4F11 by both cytokines, indicating involvement of the JNK pathway. Furthermore, TNF-α failed to induce CYP4F11 transcription when HaCaT cells were preincubated with retinoic acids. Retinoic acids are ligands for the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). The RXR agonist 6-(1(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl) nicotinic acid (LG268) greatly induced CYP4F11 transcription, whereas the RAR agonist 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid (TTNPB) markedly inhibited CYP4F11 transcription, indicating that down-regulation of CYP4F11 transcription by retinoic acid is mediated by RARs and may also be related to ligand competition for RXRs. Thus, the CYP4F11 gene is positively regulated by multiple signaling pathways in HaCaT keratinocytes, including RXR and JNK signaling pathways.
The Spectral and Thermodynamic Properties of Staphylococcal

The superantigens staphylococcal enterotoxin A and E (SEA and SEE) can activate a large number of T-cells. SEA and SEE have approximately 80% sequence identity but show some differences in their biological function. Here, the two superantigens and analogues were characterized biophysically. SEE was shown to have a substantially higher thermal stability than SEA. Both SEA and SEE were thermally stabilized by 0.1 mM Zn compared with Zn-reduced conditions achieved using 1 mM EDTA or specific replacements that affect Zn coordination. The higher stability of SEE was only partly caused by the T-cell receptor (TCR) binding regions, whereas regions in the vicinity of the major histocompatibility complex class II binding sites affected the stability to a greater extent. SEE exhibited a biphasic denaturation between pH 5.0–6.5, influenced by residues in the TCR binding regions. Interestingly, enzymelinked immunosorbent assay, isoelectric focusing, and circular dichroism analysis indicated that conformational changes had occurred in the SEA/E chimerical constructs relative to SEA and SEE. Thus, it is proposed that the Zn binding site is very important for the stability and potency of SEA and SEE, whereas residues in the TCR binding site have a substantial influence on the molecular conformation to control specificity and function.
Coordinating Coupled Self-Organized Network Functions in Cellular Radio Networks

﻿Nutzer der Mobilfunknetze wunschen und fordern eine Steigerung des Datendurchsatzes, die zur Erhohung der Netzlast fuhrt. Besonders seit der Einfuhrung von LTE erhoht sich daher die Anzahl und Dichte der Zellen in Mobilfunknetzen. Dies fuhrt zusatzlich zur Zunahme der Investitions- und Betriebskosten, sowie einer hoheren Komplexitat des Nerzbetriebs. Der Einsatz selbstorganisierter Netze (SONs) wird vorgeschlagen, um diese drei Herausforderungen zu bewaltigen. Einige SON-Funktionen (SF) wurden sowohl von Seiten der Netzbetreiber als auch von den Standardisierungsgremien vorgeschlagen. Eine SF reprasentiert hierbei eine Netzfunktion, die automatisiert werden kann. Ein Beispiel ist die Optimierung der Robustheit des Netzes (Mobility Robustness Optimization, MRO) oder der Lastausgleich zwischen Funkzellen (Mobility Load Balancing, MLB). Die unterschiedlichen SON-Funktionen werden innerhalb eines Mobilfunknetzes eingesetzt, wobei sie dabei haufig gleiche oder voneinander abhangige Parameter optimieren. Zwangslaufig treten daher beim Einsatz paralleler SON-Funktionen Konflikte auf, die Mechanismen erfordern, um diese Konflikte aufzulosen oder zu minimieren. In dieser Dissertation werden Losungen aufgezeigt und untersucht, um die Koordination der SON-Funktionen zu automatisieren und, soweit moglich, gleichma{\ss}ig zu verteilen. Im ersten Teil werden grundsatzliche Entwurfe fur SFs evaluiert, um die SON-Koordination zu vereinfachen. Basierend auf der Beobachtung, dass die Steurung der SON-Funktion sich ahnlich dem generischen Q-Learning Problem verhalt, werden die SFs als Q-Learning-Agenten entworfen. Dieser Ansatz wurde mit sehr positiven Ergebnissen auf zwei SFs (MRO und MLB) angewandt. Die als Q-Learning-Agenten entworfenen SFs werden fur zwei unterschiedliche Ansatze der SON-Koordination evaluiert. Beide Koordinierungsansatze betrachten dabei die SON-Umgebung als ein Multi-Agenten-System. Der erste Ansatz basierend auf einer raumlich-zeitlichen Entkoppelung separiert die Ausfuhrung von SF-Instanzen sowohl raumlich als auch zeitlich, um die Konflikte zwischen den SF-Instanzen zu minimieren. Der zweite Ansatz wendet kooperatives Lernen in Multi-Agenten-Systemen als automatisierten Losungsansatz zur SON-Koordination an. Die einzelnen SF-Instanzen lernen anhand von Utility-Werten, die sowohl die eigenen Metriken als auch die Metriken der Peer-SF-Instanzen auswerten. Die Intention dabei ist, durch die erlernte Zustands-Aktions-Strategie Aktionen auszufuhren, die das beste Resultat fur die aktive SF, aber auch die geringste Auswirkung auf Peer-SFs gewahrleisten. In der Evaluation des MRO-MLB-Konflikts zeigten beide Koordinierungsansatze sehr gute Resultate.
The brute within : appetitive desire in Plato and Aristotle

Introduction I. APPETITE AND REASON IN PLATO'S REPUBLIC 1. Parts of the soul 2. The argument for tripartition 3. Partition 4. The simple picture II. BELIEF AND APPEARANCE IN PLATO 5. Imitation and the soul 6. Belief and reason 7. Below belief and reason III. PHANTASIA AND NON-RATIONAL DESIRE IN ARISTOTLE 8. Preliminaries 9. Phantasia, desire, and locomotion 10. Desire without phantasia 11. The workings of phantasia 12. Phantasia and practical thought 13. Reason and non-rational desire Conclusion
The relationship between continuity and patient satisfaction: a systematic review.

BACKGROUND Continuity between doctors and patients likely affects patient satisfaction. OBJECTIVE To assess the current evidence on the relationship between continuity and patient satisfaction. METHODS Systematic review of studies of adults in general, family, or internal medicine practices with ongoing, direct, face-to-face contact with their physician. Measures of the relationship between continuity and patient satisfaction were examined. RESULTS A MEDLINE search covering 1984-2007 and a Cumulative Index to Nursing and Allied Health Literature search covering 1981-2007 identified 263 relevant studies and 12 studies met inclusion criteria. There were 12 different continuity measures and 9 different satisfaction measures. CONCLUSIONS Continuity has a variable effect on patient satisfaction.
Orientation and gap independent meta-surface bowtie antenna for WLAN applications

A meta-surface loaded bowtie antenna with orientation and gap analysis depicting multi-band features from 1.5 GHz to 7.2 GHz is proposed. The orientation and the gap between the meta-surface unit cells are altered to investigate the effect on parameters like gain, bandwidth and directivity. The bowtie antenna uses FR4 material with relativity of 4.6, loss tangent of 0.02 and thickness h = 1.5 mm as substrate. The measured results of the fabricated antenna show a positive agreement with the simulation results. The proposed antenna shows the application in the range of WLAN. ANSYS High Frequency Structural Simulator (HFSS) software is used to simulate the antenna.
MEMS and fiber optics sensor-based wearable interface for medical applications

In recent years, information technology has made remarkable advancement and found increasing, applications in various fields. In the medical field, computer is playing a more important role in assisting the disabled. However, the interface between the disabled and a computer is usually composed of push button and touch sensors that are difficult of use. This research aims to develop a more user-friendly wearable interface using a MEMS (micro electro mechanical system) accelerometer and an optical fiber shape sensor that enable the disabled to use a computer more effectively. To demonstrate the application of this wearable interface, we developed several systems including a communication device for the disabled to control computer keyboards and appliances, and a rehabilitation device referred to as a data glove. The effectiveness of the interface is demonstrated through several field tests
Sexual outcomes after organ potency-sparing surgery and glans reconstruction in patients with penile carcinoma

Introduction: Radical surgery is the “gold standard” for treatment of invasive penile carcinoma but very poor aesthetic, functional and psychological outcomes have been reported. Our purpose was to assess the impact of organ potency-sparing surgery in locally confined carcinoma of the penis. Materials and Methods: We evaluated retrospectively 42 patients with early penile cancer (Ta,T1,T2), treated with glandulectomy and glanduloplasty with urethral mucosa and sparing of cavernosal apexes, or glandulectomy and limited apical resection in cases of Stage T2. Sexual function, ejaculation and libido were evaluated with an IIEF-15 questionnaire before the appearance of neoplasia (about three months before the surgery) and six months after surgery. Quality of life was evaluated by the Bigelow-Young questionnaire. The scores relating to two weeks prior to the surgery have been compared to those obtained six months after surgery. The statistical analysis was conducted using t-Student for repeated measures and analysis of variance. Results: Six months after surgery 73% of patients reported spontaneous rigid erections, 60% coital activity while 76% of the group treated with urethral glanduloplasty reported normal ejaculation and orgasm, regained an average of 35 days after surgery. The average IIEF-15 scores reported in the entire series in the domains of erection, libido and coital activity of the pre-cancer period were not statistically different than those recorded six months after surgery. In the group treated with glandular reconstruction, pre-and postoperative IIEF-15 mean scores related to ejaculation and orgasm domains were not significantly different. Mean scores of Bigelow-Young questionnaires related to sexual pleasure, familial, social and professional relationships showed significant improvement after surgery. Conclusions: Potency sparing-sparing surgical treatments have a positive impact on a wide spectrum of the patient's life including family relationships, and social and working conditions.
The Vertex-Rainbow Index of A Graph

Abstract The k-rainbow index rxk(G) of a connected graph G was introduced by Chartrand, Okamoto and Zhang in 2010. As a natural counterpart of the k-rainbow index, we introduce the concept of k-vertex-rainbow index rvxk(G) in this paper. In this paper, sharp upper and lower bounds of rvxk(G) are given for a connected graph G of order n, that is, 0 ≤ rvxk(G) ≤ n − 2. We obtain Nordhaus-Gaddum results for 3-vertex-rainbow index of a graph G of order n, and show that rvx3(G) + rvx3(Ḡ) = 4 for n = 4 and 2 ≤ rvx3(G) + rvx3(Ḡ) ≤ n − 1 for n ≥ 5. Let t(n, k, ℓ) denote the minimal size of a connected graph G of order n with rvxk(G) ≤ ℓ, where 2 ≤ ℓ ≤ n − 2 and 2 ≤ k ≤ n. Upper and lower bounds on t(n, k, ℓ) are also obtained.
Design considerations of a battery pack — DC grid interface converter

This paper discusses the design of an interface converter that is used to connect a battery pack to a DC grid. A description of the battery pack and a previously developed battery management system with cell balancing is given. Here the battery management system plays a significant role since it provides information for the interface converter operation. The DC grid parameters and battery operational limits are used to extract the operational modes required for successful interface converter operation. The converter circuit and implementation is discussed. Additionally the control commands of the interface converter are considered since the converter is a part of a larger system with dedicated master control block that supervises the operation of all grid connected devices.