Miracle-dz/UniFAR-FTUs huggingface dataset:
Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol‐fed cystathionine beta synthase–deficient mouse

We tested the hypothesis that the pathogenesis of alcoholic liver injury is mediated by epigenetic changes in regulatory genes that result from the induction of aberrant methionine metabolism by ethanol feeding. Five‐month‐old cystathionine beta synthase heterozygous and wild‐type C57BL/6J littermate mice were fed liquid control or ethanol diets by intragastric infusion for 4 weeks. Both ethanol‐fed groups showed typical histopathology of alcoholic steatohepatitis, with reduction in liver S‐adenosylmethionine (SAM), elevation in liver S‐adenosylhomocysteine (SAH), and reduction in the SAM/SAH ratio with interactions of ethanol and genotype effects. Hepatic endoplasmic reticulum stress signals including glucose‐regulated protein‐78 (GRP78), activating transcription factor 4, growth arrest and DNA damage‐inducible gene 153 (GADD153), caspase 12, and transcription factor sterol response element binding protein‐1c (SREBP‐1c) were up‐regulated in ethanol‐fed mice with genotype interactions and negative correlations with the SAM/SAH ratio. Immunohistochemical staining showed reduction in trimethylated histone H3 lysine‐9 (3meH3K9) protein levels in centrilobular regions in both ethanol groups, with no changes in trimethylated histone H3 lysine‐4 levels. The chromatin immunoprecipitation assay revealed a decrease in levels of suppressor chromatin marker 3meH3K9 in the promoter regions of GRP78, SREBP‐1c, and GADD153 in ethanol‐treated heterozygous cystathionine beta synthase mice. The messenger RNA expression of the histone H3K9 methyltransferase EHMT2 (G9a) was selectively decreased in ethanol‐fed mice. Conclusion: The pathogenesis of alcoholic steatohepatitis is mediated in part through the effects of altered methionine metabolism on epigenetic regulation of pathways of endoplasmic reticulum stress relating to apoptosis and lipogenesis. (HEPATOLOGY 2009.)
Correlation of Thyroglobulin Concentrations Measured by Radioimmunoassay and Immunoradiometric Assay and the Influence of Thyroglobulin Antibody

Abstract There are a large number of commercial diagnostic assays for measuring thyroglobulin (Tg) concentration in human serum. The assay principle, as well as the potential presence of antithyroglobulin autoantibody (TgAb) in patient's serum, could influence the measured amount of Tg. Our objective was to determine the concentration of Tg by radioimmunoassay and immunoradiometric assay, to compare the values obtained and to investigate the influence of TgAbs on those results. Analysis of serum specimens (n = 58) showed close correlation between the investigated assays, regardless of the presence of TgAb in some samples. The mean value for Tg concentration, determined by radioimmunoassay, was 25% lower than that obtained by immunoradiometric assay. However, this ratio was not uniform for the whole population because the differences were more prominent for high values of Tg. The significant difference between these two methods was confirmed by Student's t-test, which indicated that patients must be monitored in continuity only by one selected method.
Characterization of U4 and U6 interactions with the 5' splice site using a S. cerevisiae in vitro trans-splicing system.

Spliceosome assembly has been characterized as the ordered association of the snRNP particles U1, U2, and U4/U6.U5 onto pre-mRNA. We have used an in vitro trans-splicing/cross-linking system in Saccharomyces cerevisiae nuclear extracts to examine the first step of this process, 5' splice site recognition. This trans-splicing reaction has ATP, Mg(2+), and splice-site sequence requirements similar to those of cis-splicing reactions. Using this system, we identified and characterized a novel U4-5' splice site interaction that is ATP-dependent, but does not require the branch point, the 3' splice site, or the 5' end of the U1 snRNA. Additionally, we identified several ATP-dependent U6 cross-links at the 5' splice site, indicating that different regions of U6 sample it before a U6-5' splice site interaction is stabilized that persists through the first step of splicing. This work provides evidence for ATP-dependent U4/U6 association with the 5' splice site independent of ATP-mediated U2 association with the branch point. Furthermore, it defines specific nucleotides in U4 and U6 that interact with the 5' splice site at this early stage, even in the absence of base-pairing with the U1 snRNA.
An input-to-state stability approach to verify almost global stability of a synchronous-machine-infinite-bus system

Conditions for almost global stability of an operating point of a realistic model of a synchronous generator with constant field current connected to an infinite bus are derived. The analysis is conducted by employing the recently proposed concept of input-to-state stability (ISS)–Leonov functions, which is an extension of the powerful cell structure principle developed by Leonov and Noldus to the ISS framework. Compared with the original ideas of Leonov and Noldus, the ISS–Leonov approach has the advantage of providing additional robustness guarantees. The efficiency of the derived sufficient conditions is illustrated via numerical experiments. This article is part of the themed issue ‘Energy management: flexibility, risk and optimization’.
Analyse et conception d'antennes imprimees multifilaires. Applications

Les principaux objectifs de ce travail sont la conception et la realisation d'antennes imprimees multifilaires. Les techniques de calcul utilisees sont basees sur le modele des lignes de transmission en association avec le principe de babinet et la resolution d'equations integrales tenant compte du dielectrique par la methode des moments et la methode des quatre termes. Grace a ces outils, plusieurs structures d'antennes imprimees ont ete modelisees, puis analysees et testees: les antennes monopoles simples charges ou non par des elements passifs (resistance serie, circuit rlc parallele). Ces associations ont permis d'augmenter la bande passante. Les antennes monopoles a changement de section aboutissent a une reduction de dimension. L'association des elements resistifs a ce type de structures offre egalement une augmentation de la bande passante avec toutefois une reduction de gain. Les antennes monopoles composes de plusieurs sections (triangulaire, trapezoidale) donnant a la fois la reduction de dimension et l'augmentation de la bande passante. Les antennes monopoles boucles simples et charges par une diode varactor permettant l'accord de la frequence. Dipole alimente associe a des parasites court circuites aboutissant a une augmentation de la bande passante et au phenomene de bi-frequence. Reseau de dipoles isoles ou disposes au dessus d'un plan reflecteur et alimente par une ligne bifilaire imprimee conduisant a un elargissement de la bande passante et une directivite amelioree. Reseau de deux antennes log-periodiques tete-beche offrant une bande passante de l'ordre de l'octave avec un diagramme de rayonnement large. L'ensemble de ces methodes ont conduit a des programmes de calcul implantes sur micro-ordinateur type pc
Balancing Migration: Overcoming the challenge to SaaS provisioning for core business activities: A South African case study

v Table of contents . vii List of Figures . x List of Tables . xi Acronyms . xi Chapter 1: Introduction . 12 1.1. Background . 12 1.1.1. Cloud computing . 12 1.1.2. Core business activities . 13 1.1.3. Financial Industry . 13 1.2. Problem statement . 14 1.3. Research motivation . 15 1.4. Value of the research . 17 1.5. Dissertation overview . 17 Chapter 2: Literature review . 19 2.
Genetic Study of the Paleolithic and Neolithic Southeast Asians

AbstractDNA samples were extracted from six prehistoric human remains, found on the Malay Peninsula, dating to the Paleolithic and the Neolithic periods. Nucleotide sequences of mitochondrial DNA were determined by the polymerase chain reaction-direct sequencing method. A phylogenetic tree between prehistoric and present humans was constructed based on the nucleotide sequence data. Mitochondrial DNA phylogenetic relationships and ethnoarchaeological evidence suggest that there is a continuity beetween the pre-Neolithic humans and the present Semang and that the Neolithic humans in this area might be an ancestral group of the Senoi.
Function–behavior–structure paths and their role in analogy-based design

Abstract In many creative design processes, cross-domain knowledge is required to inspire the new design result. Thus, in knowledge-based design, how we represent the cross-domain knowledge becomes a key issue. In this paper, we present a formalism for design knowledge representation. By analyzing function representation in different design domains, from graphic design and industrial design to architectural and engineering device designs, we find that although the focus of each kind of design is different, the function representation can be generalized into a small number of categories. This formalism can be used in an explorative model of design by analogy, where designs from different design domains are sources to help produce a new design.
Mini extracorporeal circuit for coronary artery bypass grafting: initial clinical and biochemical results

Background: The new concept of mini-extracorporeal circulation (MECC) for coronary artery bypass grafts (MCABG) consists of minimal priming volume, a heparin-coated closed circuit, a centrifugal pump, active drainage, blood cardioplegia and a cell-saving device. The potential organ protective effect of this technique during CABG is unknown. Initial clinical outcomes, oxidative stress, alveolar shunting and need for blood transfusion were investigated for MCABG patients. Subsets of these data were compared to outcomes of matched groups of patients operated conventionally (CCABG) and off-pump (OPCAB). Methods: Data of 184 patients were gathered and analysed from a prospective observational database system. This database consists of the initial experience with the first 114 MCABG operations. Of these, the clinical outcome was investigated. In a subset of 60 MCABGs, need for transfusion was monitored and compared to 60 CCABGs. Serum concentrations of malondialdehyde (MDA), allantoin/urate ratios, shunt fractions and lung epithelium-specific proteins (CC16) were measured as biomarkers of damage during MCABG, CCABG and OPCAB (n-30). Results: Patient groups were similar concerning age, risk and number of distal anastomoses. Clinical outcomes are shown for MCABGs only. During MCABG, need for trans-fusion was significantly reduced compared to CCABG (pB/0.001). Serum concentrations of MDA and allantoin/urate ratios showed significantly reduced oxidative stress during MCABG compared to CCABG. During MCABG, F-shunts were reduced shortly after surgery. Increased concentrations of pneumoprotein CC16 were measured during CCABG compared to MCABG (data submitted). Conclusion: Short-term clinical outcomes of MCABG patients are satisfactory. Compared to CCABG the need for transfusion is significantly reduced when a MECC is used. Oxidative stress parameters show a tendency towards improved global organ protection compared to CCABG. F-shunt fractions and CC16 concentrations suggest reduced alveolar damage during MCABG. In a prospective study, the protective effect of mini-CABG has to be confirmed.
Using Market-Level Data to Understand Promotion Effects in a Nonlinear Model

The authors show analytically, empirically, and numerically through simulation that the estimated effects from linearly aggregated market-level data differ substantially from comparable effects that are obtained from store-level data. The magnitude of this difference renders market-level data largely unsuitable for econometric modeling, unless the marketing manager compensates for the bias that results from the incompatible aggregation. The authors introduce a new approach, a relatively simple debiasing procedure derived from simulated data. They show that this debiasing approach results in substantially improved parameter estimates. They illustrate the value of the procedure by applying it to scanner data for powdered detergents and comparing the debiased parameter estimates to results obtained from store-level data and an alternative aggregation method that maintains homogeneity for selected promotional activities.
Providing SIP services support on Mobile networks

The telecommunications market is changing and it makes that telecommunications operators search for a way to offer new and attractive services for its users. This is even more important when the mobile networks infrastructure update process is considered. Latin-American operators are planning to introduce 3G networks technology on the region. However, these changes imply great inversions too. This paper presents a proposal to offer services based on session initiation protocol (SIP) with a low cost platform based on market tendencies adopting initiatives as 3GPP IP multimedia subsystem (IMS).
Factors associated with non‐participation and dropout among cancer patients in a cluster‐randomised controlled trial

We investigated the impact of demographic and disease related factors on non-participation and dropout in a cluster-randomised behavioural trial in cancer patients with measurements taken between hospitalisation and 6 months thereafter. The percentages of non-participation and dropout were documented at each time point. Factors considered to be potentially related with non-participation and dropout were as follows: age, sex, marital status, education, income, employment status, tumour site and stage of disease. Of 1,338 eligible patients, 24% declined participation at baseline. Non-participation was higher in older patients (Odds Ratio [OR] 2.1, CI: 0.6-0.9) and those with advanced disease (OR 2.0, CI: 0.1-1.3). Dropout by 6 months was 25%. Dropout was more frequent with increased age (OR 2.8, CI: 0.8-1.2), advanced disease (OR 3.0, CI: 1.0-1.2), being married (OR 2.4, CI 0.7-1.1) and less frequent with university education (OR 0.4, CI -1.3 to -0.8) and middle income (OR 0.4, CI -0.9 to -0.7). When planning clinical trials, it is important to be aware of patient groups at high risk of non-participation or dropout, for example older patients or those with advanced disease. Trial designs should consider their special needs to increase their rate of participation.
Modelling and Simulating Time Use of Site Workers With 4d BIM

This paper presents a research endeavouring to model site work in a 4D BIM model. Next simulations are performed with this model in 5 scenarios including specific interventions in work organisation, notably changing positons of facilities for site workers. A case study has been done in a construction project in the Netherlands. The research has showed the possibility to model time use of site workers in 4D BIM. Next the research has showed potential to perform and calculate specific interventions in the model, and prospect realistic changes in productive time use as a result.
Axon Function Persists during Anoxia in Mammalian White Matter

Axon function in the CNS has been reported to fail rapidly during anoxia, implying that there is no anaerobic capacity. This phenomenon was reassessed in rodent white matter using mouse or rat optic nerve. Axon function was semiquantitatively measured as area under the compound action potential. Mouse optic nerves exposed to anoxia (30–180 minutes) or cyanide (30–60 minutes) at 37°C exhibited significant persistent function that was abolished by removing glucose. Reduction in compound action potential area increased with anoxia duration reaching a maximum of about 70% after 90 min. Rat optic nerves exposed to anoxia, in contrast to mouse optic nerves, showed rapid and complete loss of function. When artificial CSF glucose was increased from 10 to 30 mmol/L, rat optic nerves responded to anoxia in a similar manner to mouse optic nerves in 10-mmol/L glucose. The authors conclude that white matter is resistant to anoxia with a subset of axons able to subsist exclusively on anaerobically derived energy. Because the rat optic nerve is about twice the diameter of the mouse optic nerve, glucose diffusion into the rat optic nerve was inadequate during anoxia when artificial CSF glucose was 10 mmol/L but became adequate when artificial CSF glucose was 30 mmol/L. These observations have implications for white matter energy metabolism and susceptibility to injury during focal ischemia.
Migration von AUTOSAR-basierten Echtzeitanwendungen auf Multicore-Systeme

Kurzfassung—Selbst sicherheitskritische Echtzeitanwendungen im Automobilbereich werden in naher Zukunft auf Multicore-Systeme migriert werden, um den steigenden Innovationshunger nach neuen Produktmerkmalen decken zu können. Eine manuelle Migration der über Jahre gewachsenen Softwarebasis ist, schon aufgrund des Umfangs der zu migrierenden Software, kaum zu leisten. Hinzu kommen die kaum zu durchschauenden Abhängigkeiten der Softwarebestandteile untereinander, die mühevoll analysiert und bewertet werden müssen, um eine korrekte Migration durchzuführen. Dieser Beitrag stellt einen neuartigen Ansatz für das automatische Auffinden und Bewerten von Abhängigkeiten mit Hilfe statischer Programmanalysen vor. Die ebenfalls vorgestellten ersten Ergebnisse stützen die These, dass das Konzept zur teilautomatisierten Migration von Echtzeitsoftware auf Multicore-Systeme einsetzbar ist.
A high-performance wear-leveling algorithm for flash memory system

In this paper, a low-complexity high-performance wearleveling algorithm which named sequential garbage collection (SGC) for flash memory system design is presented. The proposed SGC outperforms existing designs in terms of wear evenness and low design complexity. The lifetime of the flash memory can be greatly lengthened by the proposed SGC. The proposed SGC doesn’t require any tuning threshold parameter, and thus it can be applied to various systems without prior knowledge of the system environment for threshold tuning. Simulation results show that the maximum block erase count and standard deviation of the block erase count compared to the greedy algorithm are decreased by up to 75% and 94%, respectively.
Closing Information Gaps with Need-driven Knowledge Sharing

Closing Information Gaps with Need-driven Knowledge Sharing Knowledge management systems for asynchronous knowledge sharing – such as Intranets, Wikis, or file shares – often suffer from a lack of contributions. This is mainly because information providers are decoupled from information seekers, and thus have limited awareness about their actual information needs. Therefore, the questions which knowledge is worth sharing and how to motivate people to share knowledge, are core issues of knowledge management. To this end, we describe a novel approach called need-driven knowledge sharing (NKS), which consists of three elements. The first deals with indicators of information need – especially search queries – which are aggregated in order to derive continuous forecasts of organizational information needs (OIN). By comparing with private and shared information spaces, organizational information gaps (OIG) are derived to identify missing information. These gaps can be made transparent using so called mediation services and mediation spaces, which help to create awareness for organizational information needs and to guide knowledge sharing. The realization of NKS is illustrated by three tools, which are all based on established knowledge management systems. Inverse Search is a tool that identifies documents in the private information space of information providers, which may help closing organizational information gaps if moved to a shared information space. Woogle extends Wikis with features that identify and prioritize incomplete or missing information based on other users’ information needs. Similarly, Semantic Need is an extension to Semantic MediaWiki that guides the creation of semantic data by analyzing information needs expressed through structured queries. The implementation and evaluation of all three tools shows, that need-driven knowledge sharing is technically feasible and can be a helpful extension to knowledge management practices. The concepts of mediation services and mediation spaces provide a framework to analyze and extend other tools with respect to NKS. Finally, our approach may also spark improvements of Internetscale services and infrastructures, such as the Wikipedia or the Semantic Web.
The fraction of exhaled nitric oxide improves prediction of clinical allergic reaction to peanut challenge in children

Retrospective studies of childhood peanut allergy demonstrate serum‐specific IgE (IgE) levels against the peanut allergen Ara h2 may help predict a clinical reaction at food challenge. Fraction of exhaled nitric oxide (FeNO) is a non‐invasive tool correlating to allergic airways inflammation and has been independently associated with increased food‐specific IgE.
A Deep Neural Network Approach To Parallel Sentence Extraction

Parallel sentence extraction is a task addressing the data sparsity problem found in multilingual natural language processing applications. We propose an end-to-end deep neural network approach to detect translational equivalence between sentences in two different languages. In contrast to previous approaches, which typically rely on multiples models and various word alignment features, by leveraging continuous vector representation of sentences we remove the need of any domain specific feature engineering. Using a siamese bidirectional recurrent neural networks, our results against a strong baseline based on a state-of-the-art parallel sentence extraction system show a significant improvement in both the quality of the extracted parallel sentences and the translation performance of statistical machine translation systems. We believe this study is the first one to investigate deep learning for the parallel sentence extraction task.
Customers’ Perceptions as an Antecedent of Satisfaction with Online Retailing Services

The assessment of antecedents of customer satisfaction has become very important for the success of online retailing services. This paper reports the results of a study that investigated the antecedent role of customers’ perceptions vis-a-vis satisfaction with online retailing services. While the study model conceptualizes customers’ perceptions as a composite variable made up of three dimensions (perceived attributes, perceived risk and perceived value) prescribed by four established information systems (IS) and consumer behaviour frameworks, namely the Technology Acceptance Model (TAM), Perceived Risk Theory (PRT), Theory of Consumption Values (TCV) and Expectations-Artifact Model of Satisfaction (EAMS), it does not specify how the different perceptual factors infl uence online satisfaction; instead it aggregates all three dimensions into a higher-order construct called “customers’ perceptions” and tries to understand the nature of relationship between the composite independent variable and the dependent variable. It employed a descriptive, correlational survey design whereby the response data collected from 240 registered users of 6 online retailers was analyzed using both descriptive as well as inferential statistics. The linear regression analyses indicate that the model provides a statistically signifi cant explanation of the variation in consumers’ online retailing satisfaction. The study also found empirical support for customers’ perceptions as an antecedent of satisfaction with online retailing services. JEL classifi cation: