Miracle-dz/UniFAR-FTUs huggingface dataset:
Noncancer pain conditions and risk of suicide.

IMPORTANCE There are limited data on the extent to which suicide mortality is associated with specific pain conditions. OBJECTIVE To examine the associations between clinical diagnoses of noncancer pain conditions and suicide among individuals receiving services in the Department of Veterans Affairs Healthcare System. DESIGN Retrospective data analysis. SETTING Data were extracted from National Death Index and treatment records from the Department of Veterans Healthcare System. PARTICIPANTS Individuals receiving services in fiscal year 2005 who remained alive at the start of fiscal year 2006 (N = 4 863 086). MAIN OUTCOMES AND MEASURES Analyses examined the association between baseline clinical diagnoses of pain-related conditions (arthritis, back pain, migraine, neuropathy, headache or tension headache, fibromyalgia, and psychogenic pain) and subsequent suicide death (assessed in fiscal years 2006-2008). RESULTS Controlling for demographic and contextual factors (age, sex, and Charlson score), elevated suicide risks were observed for each pain condition except arthritis and neuropathy (hazard ratios ranging from 1.33 [99% CI, 1.22-1.45] for back pain to 2.61 [1.82-3.74] for psychogenic pain). When analyses controlled for concomitant psychiatric conditions, the associations between pain conditions and suicide death were reduced; however, significant associations remained for back pain (hazard ratio, 1.13 [99% CI, 1.03-1.24]), migraine (1.34 [1.02-1.77]), and psychogenic pain (1.58 [1.11-2.26]). CONCLUSIONS AND RELEVANCE There is a need for increased awareness of suicide risk in individuals with certain noncancer pain diagnoses, in particular back pain, migraine, and psychogenic pain.
Error exponents in asynchronous communication

Based on recent work on asynchronous communication, this paper proposes a slotted asynchronous channel model and investigates the fundamental limits of asynchronous communication, in terms of miss and false alarm error exponents. We propose coding schemes that are suitable for various asynchronous communication scenarios, and quantify more precisely the suboptimality of training-based schemes, i.e., communication strategies that separate synchronization from information transmission. In particular, we show that under a broad set of conditions, training-based schemes are suboptimal at all positive rates. Finally, we demonstrate these performance differences by specializing our results to BSCs and AWGN channels.
PartMOR: Partitioning-Based Realizable Model-Order Reduction Method for RLC Circuits

This paper presents a robust partitioning-based model-order reduction (MOR) method, PartMOR, suitable for reduction of very large RLC circuits or RLC-circuit parts of a non-RLC circuit. The MOR is carried out on a partitioned circuit, which enables the use of low-order moments and macromodels of few elements, while still preserving good accuracy for the reduction. As the method produces a positive-valued, passive, and stable reduced-order RLC circuit (netlist-in-netlist-out), it can be used in conjunction with any standard analysis tool or circuit simulator without modification. It is shown that PartMOR achieves excellent reduction results in terms of accuracy and reduced CPU time for RLC, RC, and RL circuits.
S-Nitrosoglutathione Accelerates Recovery from 5-Fluorouracil-Induced Oral Mucositis

Introduction Mucositis induced by anti-neoplastic drugs is an important, dose-limiting and costly side-effect of cancer therapy. Aim To evaluate the effect of the topical application of S-nitrosoglutathione (GSNO), a nitric oxide donor, on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters. Materials and Methods Oral mucositis was induced in male hamsters by two intraperitoneal administrations of 5-FU on the first and second days of the experiment (60 and 40 mg/kg, respectively) followed by mechanical trauma on the fourth day. Animals received saline, HPMC or HPMC/GSNO (0.1, 0.5 or 2.0 mM) 1 h prior to the 5-FU injection and twice a day for 10 or 14 days. Samples of cheek pouches were harvested for: histopathological analysis, TNF-α and IL-1β levels, immunohistochemical staining for iNOS, TNF-α, IL-1β, Ki67 and TGF-β RII and a TUNEL assay. The presence and levels of 39 bacterial taxa were analyzed using the Checkerboard DNA-DNA hybridization method. The profiles of NO released from the HPMC/GSNO formulations were characterized using chemiluminescence. Results The HPMC/GSNO formulations were found to provide sustained release of NO for more than 4 h at concentration-dependent rates of 14 to 80 nmol/mL/h. Treatment with HPMC/GSNO (0.5 mM) significantly reduced mucosal damage, inflammatory alterations and cell death associated with 5-FU-induced oral mucositis on day 14 but not on day 10. HPMC/GSNO administration also reversed the inhibitory effect of 5-FU on cell proliferation on day 14. In addition, we observed that the chemotherapy significantly increased the levels and/or prevalence of several bacterial species. Conclusion Topical HPMC/GSNO accelerates mucosal recovery, reduces inflammatory parameters, speeds up re-epithelization and decreases levels of periodontopathic species in mucosal ulcers.
Expression and localization of HrpA1, a protein of Xanthomonas campestris pv. vesicatoria essential for pathogenicity and induction ofthe hypersensitive reaction

The hrp cluster of the pepper and tomato pathogen Xanthomonas campestris pv. vesicatoria is required for both pathogenicity on susceptible host plants and induction of the hypersensitive reaction on resistant plants. The hrpA locus is located at the left end of the 25-kb hrp region and encodes a single 64-kDa Hrp protein, HrpA1, which belongs to the PulD superfamily of proteins involved in type II and type III protein secretion. In this study, we developed a defined medium without any plant-derived molecules that induces expression of hrpA in vitro. The hrpA transcription start site was mapped in the coding region of the hrpB8 gene, which is the last gene of the hrpB operon. The inducible hrpA promoter shows no homology to known promoter elements or other hrp loci of X. campestris pv. vesicatoria. hrpA expression was shown to be independent of the hrp regulatory gene hrpX. The amino acid sequence of the HrpA1 protein is predicted to contain an N-terminal signal sequence and no further transmembrane domains and to be rich in beta-sheet stretches. Expression of HrpA1 in Escherichia coli cells causes induction of the psp operon like some of its counterparts, suggesting some commonality of function and that HrpA1 forms multimers. The protein product of hrpA1 was identified by using a specific polyclonal antibody. Cell fractionation studies demonstrated that the HrpA1 protein is localized in the outer membrane of X. campestris pv. vesicatoria. HrpA1 is the first component of the Hrp secretion system whose localization has been determined in the original organism.
Attentional mechanisms in the generation of sympathy

Empathic responses, such as sympathy towards others, are a key ingredient in the decision to provide help to those in need. The determinants of empathic responses are usually thought to be the vividness, similarity, and proximity of the victim. However, recent research highlights the role that attention plays in the generation of feelings. We expanded on this idea by investigating whether sympathy depends on cognitive mechanisms such as attention. In two studies we found that sympathy responses were lower and reaction times were longer when targets were presented with distractors. In addition, online sympathy judgments that allow attentional focusing on a target lead to greater affective responses than judgments made from memory. We conclude that attention is an ingredient in the generation of sympathy, and discuss implications for research on prosocial behaviour and the interaction between attention and emotions.
Log-linear Combinations of Monolingual and Bilingual Neural Machine Translation Models for Automatic Post-Editing

This paper describes the submission of the AMU (Adam Mickiewicz University) team to the Automatic Post-Editing (APE) task of WMT 2016. We explore the application of neural translation models to the APE problem and achieve good results by treating different models as components in a log-linear model, allowing for multiple inputs (the MT-output and the source) that are decoded to the same target language (post-edited translations). A simple string-matching penalty integrated within the log-linear model is used to control for higher faithfulness with regard to the raw machine translation output. To overcome the problem of too little training data, we generate large amounts of artificial data. Our submission improves over the uncorrected baseline on the unseen test set by -3.2\% TER and +5.5\% BLEU and outperforms any other system submitted to the shared-task by a large margin.
COL-3, a Chemically Modified Tetracycline, Inhibits Lipopolysaccharide-Induced Microglia Activation and Cytokine Expression in the Brain

Microglia activation results in release of proinflammatory molecules including cytokines, which contribute to neuronal damage in the central nervous system (CNS) if not controlled. Tetracycline antibiotics such as minocycline inhibit microglial activation and cytokine expression during CNS inflammation. In the present study we found that administration of chemically modified tetracycline-3 (COL-3), inhibits lipopolysaccharide (LPS)-induced microglial and p38 MAPK activation, as well as the increase in TNF-α, but not IL-1β expression, in the brains of BALB/c mice. COL-3 has been described to have no antibacterial activity. We observed that COL-3 had no activity against a Gram-negative bacteria, Escherichia coli; however surprisingly, COL-3 had antibacterial activity against a Gram-positive bacteria Staphylococcus aureus, with a minimum inhibitory concentration of 1 mg/ml. Our data show that COL-3 has some antibacterial activity against S. aureus, inhibits LPS-induced neuroinflammation, and displays potential as a therapeutic agent for treatment of conditions involving CNS inflammation.
Bosniak classification for complex renal cysts: history and critical analysis

The Bosniak classification for renal cysts was developed in the late 1980s in an attempt to standardize the description and management of complex cystic renal lesions. Alterations were made to such a classification in the 1990s and, the last one, in 2005. Currently, five categories of cystic renal lesions are defined - namely, I, II, II-F, III and IV –, according to their degree of complexity and likelihood of malignancy. Despite being initially described for computed tomography, this classification has been also utilized with some advantages also for magnetic resonance imaging. The present article reviews the different phases of this classification, its diagnostic efficacy and the most controversial features of its use.
A single-trim CMOS bandgap reference with a 3σ inaccuracy of ±0.15% from −40°C to 125°C

This paper describes a CMOS bandgap reference with an inaccuracy of ±0.15% (3σ) from −40°C to 125°C. This level of performance, previously only achieved by trimming at two or more temperatures [1, 2], was obtained by using chopping and curvature correction to minimize non-PTAT (proportional-to-absolute-temperature) errors, and canceling residual PTAT errors with a single room-temperature trim.
A Rice Phenolic Efflux Transporter Is Essential for Solubilizing Precipitated Apoplasmic Iron in the Plant Stele*

Iron deficiency is one of the major agricultural problems, as 30% of the arable land of the world is too alkaline for optimal crop production, rendering plants short of available iron despite its abundance. To take up apoplasmic precipitated iron, plants secrete phenolics such as protocatechuic acid (PCA) and caffeic acid. The molecular pathways and genes of iron uptake strategies are already characterized, whereas the molecular mechanisms of phenolics synthesis and secretion have not been clarified, and no phenolics efflux transporters have been identified in plants yet. Here we describe the identification of a phenolics efflux transporter in rice. We identified a cadmium-accumulating rice mutant in which the amount of PCA and caffeic acid in the xylem sap was dramatically reduced and hence named it phenolics efflux zero 1 (pez1). PEZ1 localized to the plasma membrane and transported PCA when expressed in Xenopus laevis oocytes. PEZ1 localized mainly in the stele of roots. In the roots of pez1, precipitated apoplasmic iron increased. The growth of PEZ1 overexpression lines was severely restricted, and these lines accumulated more iron as a result of the high solubilization of precipitated apoplasmic iron in the stele. We show that PEZ1 is responsible for an increase of PCA concentration in the xylem sap and is essential for the utilization of apoplasmic precipitated iron in the stele.
The Advantages and Challenges of Diversity in Pharmacogenomics: Can Minority Populations Bring Us Closer to Implementation?

Health disparities exist among minorities in the United States, with differences seen in disease prevalence, mortality, and responses to medications. These differences are multifactorial with genetic variation explaining a portion of this variability. Pharmacogenomics aims to find the effect of genetic variations on drug response, with the goal of optimizing drug therapy and development. Although genome‐wide association studies have been useful in unbiasedly surveying the genome for genetic drivers of clinically relevant phenotypes, most of these studies have been conducted in mainly participants of European and Asian descent, contributing to a growing health disparity in precision medicine. Diversity is important to pharmacogenomic studies, and there may be real advantages to the use of these complex genomes in pharmacogenomics. In this review we will outline some of the advantages and confounders of pharmacogenomics in minorities, describe the role of genetic variation in pharmacologic pathways, and highlight a number of population‐specific findings.
Information Management and Technology (IM&T): training provision in postgraduate medical education

Information Management and Technology (IM&T) is assuming a greater role within the modern NHS and there is an increasing need for members of the medical, and other health care, professions to receive appropriate training and education in these areas. Over half the Postgraduate Deans, Regional Advisers in General Practice and the Medical Royal Colleges have made a conscious decision to supply training in IM&T‐related areas. These courses are open to a wide range of health care professionals. However, the number of reported places is not adequate for the large number of people who require the training. Less than half the organizations employed staff with a remit to provide training but over half provided courses in collaboration with educational establishments. As the medical undergraduate curriculum changes and incorporates training in computer skills, the links between the postgraduate institutions and medical schools must be fostered and developed. This will lead to increasing opportunities for health professionals both in the range of subjects and the number of places available.
Unfolding presence: an interpretative phenomenological analysis of photography

Media theorist Marshall McLuhan argued that media actively shape and transform the spatial, temporal and biopsychosocial dimensions of our lives, facilitating modes of perception and experience that are, arguably, medium-specific. Seeking to better understand the movements of mediation that unfold in and through acts of photography, I conducted a series of in-depth interviews with five artist-photographers in which I asked them to describe what photography does for and to them, what it ‘affords’ and what it ‘requires. ’ Through these interviews, the medium and practice of photography emerged as an influential participant in a range of complex existential and hermeneutic processes. Drawing on Deleuze’s concept of the fold, I mapped the movements of mediation as they unfold in embodied consciousness as a flow of un/folding a sense of time, space and presence, of enfolding embodied being-in-the world and of infolding a range of contexts that give perception a place in experience.
Individual boundary Management: an Empirical Investigation on Technology-Related Tactics

Elevated through the increasing digitalization, employees are expected to be available always and everywhere. According to boundary theory, individuals can manage their boundaries between work and private life on a continuum of integration and separation. As individuals have different preferences for integration or separation, they are implementing IT tactics to meet their preferences. However, there is a lack of research addressing this topic. Therefore, we used an exploratory approach using tools from grounded theory in order to detect IT-related tactics which employees use to manage their boundaries between work and private life in a way that is in line with their preferences. We identified six tactics that varied in their ability to foster integration or separation and could be administered either manually or automatically. These tactics ranged from physical detachment in which employees separate work and private life manually through creating distance between the device and themselves up to dynamic filters with which the device automatically filters messages from different people and lets only relevant messages come through.
What are the risks?

Researchers investigated the effectiveness of offering financial incentives in helping pregnant smokers to quit. A randomised controlled trial was performed. The intervention consisted of routine care plus incentives of up to £400 (€559; $600) for women who attended specialist pregnancy stop smoking services and were abstinent from smoking at 34-38 weeks’ gestation. The control group received routine care only, which included offers of face to face appointments to discuss smoking and cessation, free nicotine replacement therapy, and weekly support phone calls. The setting was a materially deprived inner city population in the west of Scotland. Participants were 612 self reported pregnant smokers aged at least 16 years who were less than 24 weeks pregnant. Women were randomised to the intervention (n=306) or control (n=306). Consent, including consent to use any data collected, was subsequently withdrawn by three women allocated to the control group, resulting in a sample size of 303 for analysis of the primary outcome.1 The primary outcome was abstinence from smoking at 34-38 weeks’ gestation. The percentage of smokers who were abstinent at 34-38 weeks’ gestation was significantly higher in the financial incentives group than in the control group (22.55% (n=69) v 8.58% (n=26), absolute risk difference 13.97%; relative risk 2.63, 95% confidence interval 1.73 to 4.01; P<0.001). The researchers concluded that financial incentives were effective in helping pregnant smokers quit. Which of …
Characterization of YjjJ toxin of Escherichia coli

Reminiscent of eukaryotic apoptotic programmed cell death, bacteria also contain a large number of suicide genes, which are in general co-expressed with their cognate antitoxin genes. These systems called the toxin-antitoxin (TA) systems are associated with cellular dormancy, and play major roles in biofilm formation and persistent multidrug resistance of many human pathogens. In recent years, the study on TA system toxins has become a hot topic due to the health implications of these toxins by virtue of their role in bacterial pathogenicity. Here we report functional characterization of a hitherto uncharacterized Escherichia coli TA toxin, YjjJ. YjjJ exhibits several uncommon properties: (i) unlike the genes encoding most type II TA system toxins, the gene encoding YjjJ is present as a single gene and not in an operon, (ii) despite being a homolog of the well-characterized toxin HipA, YjjJ seems to have different cellular target(s), and (iii) HipB, the cognate antitoxin of HipA, also acts as an antitoxin for YjjJ. This forms a basis for an interesting next step in the study of TA systems with respect to cross-regulation between various TA systems and the evolutionary as well as clinical significance of these observations.
Increases in guinea pig small intestinal transepithelial resistance induced by osmotic loads are accompanied by rapid alterations in absorptive-cell tight-junction structure

In some epithelia, mucosal exposure to osmotic loads produces an increase in transepithelial resistance that is presumed to relate to the collapse of the paracellular spaces. Since proximal small intestinal epithelium may transiently encounter osmotic loads during normal digestion, we examined the short-term effect of osmotic loads on resistance and on epithelial structure of mucosal sheets prepared from guinea pig jejunum using Ussing-chamber, thin-section electron- microscopic, and freeze-fracture techniques. After equilibration of mucosal sheets in chambers, mucosal buffer tonicity was increased to 600 mosM with mannitol. This resulted in a 64% increase in resistance within 20 min. Concomitantly, 600 mosM produced a decrease in tight- junction cation selectivity as judged from dilution potentials, collapse of paracellular spaces, decreased cytoplasmic electron density in 10-40% of absorptive cells, and focal absorptive-cell subjunctional lateral-membrane evaginations often associated with microfilament arrays. Freeze-fracture replicas of absorptive-cell tight junctions revealed significant increases in both strand count and depth. Preincubation with 5 micrograms/ml cytochalasin D reduced the 600 mosM resistance increase caused by 600 mosM exposure by 48% but did not prevent the collapse of paracellular spaces. Lowered temperatures that produced morphologic evidence consistent with a gel-phase transition of absorptive-cell lateral membranes prevented both the resistance response and the alterations in tight-junction structure. In conclusion, transient osmotic loads produce an increase in resistance in jejunal epithelium and alter both absorptive-cell tight-junction charge selectivity and structure. These responses, which may have physiologic implications, can be reduced by cytoskeletal inhibitors and ablated by conditions that restrict mobility of absorptive-cell lateral- membrane molecules.