Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation

Anti-pathogen adoptive T-cell immunotherapy has been proven to be highly effective in preventing or controlling viral infections following hematopoietic stem cell transplantation. Recent advances in manufacturing protocols allow an increased number of targeted pathogens, eliminate the need for viral transduction, broaden the potential donor pool to include pathogen-naïve sources, and reduce the time requirement for production. Early studies suggest that anti-fungal immunotherapy may also have clinical benefit. Future advances include further broadening of the pathogens that can be targeted and development of T-cells with resistance to pharmacologic immunosuppression.
Group rekeying with limited unicast recovery

In secure group communications, a key server can deliver a group-oriented rekey message [Chung Kei Wong et al., 1998] to a large number of users efficiently using IP multicast. For reliable delivery, Keystone [Chung Kei Wong and Lam, SS, 2000] proposed the use of forward error correction (FEC) in an initial multicast, followed by the use of unicast delivery for users that cannot recover their new keys from the multicast. In this paper, we investigate how to limit unicast recovery to a small fraction /spl gamma/ of the user population. By specifying a very small /spl gamma/, almost all users in the group will receive their new keys within a single multicast round. We present analytic models for deriving /spl gamma/ as a function of the amount of FEC redundant information and the keying interval duration for both Bernoulli and two-state Markov Chain loss models. From our analyses, we conclude that /spl gamma/ decreases roughly at an exponential rate as h increases. we then present a protocol designed to adaptively adjust (h,T) to achieve a specified /spl gamma/. In particular, our protocol chooses from among all feasible (h,T) pairs one with h and T values close to their feasible minima. Our protocol also adapts to an increase in network traffic. Simulation results using ns-2 show that with network congestion our adaptive FEC protocol can still achieve a specified /spl gamma/ by adjusting values of h and T.
Cooperative User Models in Statistical Dialog Simulators

Statistical user simulation is a promising methodology to train and evaluate the performance of (spoken) dialog systems. We work with a modular architecture for data-driven simulation where the "intentional" component of user simulation includes a User Model representing user-specific features. We train a dialog simulator that combines traits of human behavior such as cooperativeness and context with domain-related aspects via the Expectation-Maximization algorithm. We show that cooperativeness provides a finer representation of the dialog context which directly affects task completion rate.
Neural Elements for Predictive Coding

Predictive coding theories of sensory brain function interpret the hierarchical construction of the cerebral cortex as a Bayesian, generative model capable of predicting the sensory data consistent with any given percept. Predictions are fed backward in the hierarchy and reciprocated by prediction error in the forward direction, acting to modify the representation of the outside world at increasing levels of abstraction, and so to optimize the nature of perception over a series of iterations. This accounts for many ‘illusory’ instances of perception where what is seen (heard, etc.) is unduly influenced by what is expected, based on past experience. This simple conception, the hierarchical exchange of prediction and prediction error, confronts a rich cortical microcircuitry that is yet to be fully documented. This article presents the view that, in the current state of theory and practice, it is profitable to begin a two-way exchange: that predictive coding theory can support an understanding of cortical microcircuit function, and prompt particular aspects of future investigation, whilst existing knowledge of microcircuitry can, in return, influence theoretical development. As an example, a neural inference arising from the earliest formulations of predictive coding is that the source populations of forward and backward pathways should be completely separate, given their functional distinction; this aspect of circuitry – that neurons with extrinsically bifurcating axons do not project in both directions – has only recently been confirmed. Here, the computational architecture prescribed by a generalized (free-energy) formulation of predictive coding is combined with the classic ‘canonical microcircuit’ and the laminar architecture of hierarchical extrinsic connectivity to produce a template schematic, that is further examined in the light of (a) updates in the microcircuitry of primate visual cortex, and (b) rapid technical advances made possible by transgenic neural engineering in the mouse. The exercise highlights a number of recurring themes, amongst them the consideration of interneuron diversity as a spur to theoretical development and the potential for specifying a pyramidal neuron’s function by its individual ‘connectome,’ combining its extrinsic projection (forward, backward or subcortical) with evaluation of its intrinsic network (e.g., unidirectional versus bidirectional connections with other pyramidal neurons).
Conductivity of microfibrillar polymer-polymer composites with CNT-loaded microfibrils or compatibilizer: A comparative study

Conductive polymer composites have wide ranging applications, but when they are produced by conventional melt blending, high conductive filler loadings are normally required, hindering their processability and reducing mechani- cal properties. In this study, two types of polymer-polymer composites were studied: i) microfibrillar composites (MFC) of polypropylene (PP) and 5 wt% carbon nanotube (CNT) loaded poly(butylene terephthalate) (PBT) as reinforcement, and ii) maleic anhydride-grafted polypropylene (PP-g-MA) compatibilizer, loaded with 5 wt% CNTs introduced into an MFC of PP and poly(ethylene terephthalate) (PET) in concentrations of 5 and 10 wt%. For the compatibilized composite type, PP and PET were melt-blended, cold-drawn and pelletized, followed by dry-mixing with PP-g-MA/CNT, re-extrusion at 200°C, and cold-drawing. The drawn blends produced were compression moulded to produce sheets with MFC structure. Using scanning electron microscopy, CNTs coated with PP-g-MA could be observed at the interface between PP matrix and PET microfibrils in the compatibilized blends. The volume resistivities tested by four-point test method were: 2.87·10 8 and 9.93·10 7 ! ·cm for the 66.5/28.5/5 and 63/27/10 (by wt%) PP/PET/(PP-g-MA/CNT) blends, corresponding to total CNT loadings (in the composites) of 0.07 vol% (0.24 wt%) and 0.14 vol% (0.46 wt%), respectively. For the non-compatibilized MFC types based on PP/(PBT/CNT) with higher and lower melt flow grades of PP, the resistivities of 70/(95/5) blends were 1.9·10 6 and 1.5·10 7 ! ·cm, respectively, corresponding to a total filler loading (in the composite) of 0.44 vol% (1.5 wt%) in both MFCs.
An X-Ray Diffraction Method to Determine Stress at Constant Penetration/Information Depth

A rigorous strategy for (X-ray) diffraction stress measurements at fixed penetration/information depths is described. Thereby errors caused by lack of penetration-depth control in traditional (X-ray) diffraction (sin2ψ) measurements are annulled. The ranges of accessible penetration/information depths and experimental aspects are briefly discussed. The power of the method is illustrated by the analysis of an only small stress gradient in a sputter-deposited nickel layer.
Connected fermat spirals for layered fabrication

We develop a new kind of "space-filling" curves, connected Fermat spirals, and show their compelling properties as a tool path fill pattern for layered fabrication. Unlike classical space-filling curves such as the Peano or Hilbert curves, which constantly wind and bind to preserve locality, connected Fermat spirals are formed mostly by long, low-curvature paths. This geometric property, along with continuity, influences the quality and efficiency of layered fabrication. Given a connected 2D region, we first decompose it into a set of sub-regions, each of which can be filled with a single continuous Fermat spiral. We show that it is always possible to start and end a Fermat spiral fill at approximately the same location on the outer boundary of the filled region. This special property allows the Fermat spiral fills to be joined systematically along a graph traversal of the decomposed sub-regions. The result is a globally continuous curve. We demonstrate that printing 2D layers following tool paths as connected Fermat spirals leads to efficient and quality fabrication, compared to conventional fill patterns.
Relation Inference in Lexical Networks ... with Refinements

Improving lexical networks quality is an important issue in the creation process of these language resources. This can be done by automatically inferring new relations from already existing ones with the purpose of (1) densifying the relations to cover the eventual lack of information and (2) detecting errors. In this paper, we devise such an approach applied to the JeuxDeMots lexical network, which is a freely available lexical and semantic resource for French. We first present the principles behind the lexical network construction with crowdsourcing and games with a purpose and illustrated them with JeuxDeMots (JDM). Then, we present the outline of an elicitation engine based on an inference engine using schemes like deduction, induction and abduction which will be referenced and briefly presented and we will especially highlight the new scheme (Relation Inference Scheme with Refinements) added to our system. An experiment showing the relevance of this scheme is then presented.
Channel Estimation for Hybrid Architecture-Based Wideband Millimeter Wave Systems

Hybrid analog and digital precoding allows millimeter wave (mmWave) systems to achieve both array and multiplexing gain. The design of the hybrid precoders and combiners, though, is usually based on the knowledge of the channel. Prior work on mmWave channel estimation with hybrid architectures focused on narrowband channels. Since mmWave systems will be wideband with frequency selectivity, it is vital to develop channel estimation solutions for hybrid architectures-based wideband mmWave systems. In this paper, we develop a sparse formulation and compressed sensing-based solutions for the wideband mmWave channel estimation problem for hybrid architectures. First, we leverage the sparse structure of the frequency-selective mmWave channels and formulate the channel estimation problem as a sparse recovery in both time and frequency domains. Then, we propose explicit channel estimation techniques for purely time or frequency domains and for combined time/frequency domains. Our solutions are suitable for both single carrier-frequency domain equalization and orthogonal frequency-division multiplexing systems. Simulation results show that the proposed solutions achieve good channel estimation quality, while requiring small training overhead. Leveraging the hybrid architecture at the transceivers gives further improvement in estimation error performance and achievable rates.
Use of brain computer interface to drive: preliminary results

This paper reports on the implementation of a non-invasive electroencephalography-based brain-computer interface to control functions of a car in a driving simulator. The system is comprised of a Cleveland Medical Devices BioRadio 150 physiological signal recorder, a MATLAB-based BCI and an OKTAL SCANeR advanced driving experience simulator. The system utilizes steady-state visual-evoked potentials for the BCI paradigm, elicited by frequency-modulated high-power LEDs and recorded with the electrode placement of Oz-Fz with Fz as ground. A three-class online brain-computer interface was developed and interfaced with an advanced driving simulator to control functions of the car, including acceleration and steering. The findings are mainly exploratory but provide an indication of the feasibility and challenges of brain-controlled on-road cars for the future, in addition to a safe, simulated BCI driving environment to use as a foundation for research into overcoming these challenges.
Application Worthy SPIONs: Coated Magnetic Nanoparticles

Superparamagnetic iron oxide nanoparticles (SPIONs) made using magnetite (Fe3O4) are among the various important nanosystems under active investigation for biological applications. Various characterization techniques are required to judge the quality and application worthiness of magnetic nanoparticles (NPs). Magnetite NPs were synthesized by thermal decomposition method using triethylene glycol and benzyl ether as solvents and oleic acid as surfactant with a narrow size distribution. Furthermore, magnesium oxide (MgO) is coated on these magnetite NPs to protect the magnetic nuclei from oxidation. Spherical shaped, uniformly sized, and well-dispersed NPs of ~8 ± 2 nm were studied by field emission scanning electron microscopy and high-resolution transmission electron microscopy. Cation vacancies on the surface lead to the nonmagnetic Fe2O3 phase on the surface of Fe3O4 NPs. MgO coated Fe3O4 NPs prevented the oxidation on NP surface, which is shown through infrared, Raman and Mössbauer spectroscopy studies. Magnetization studies of oleic acid and MgO coated magnetite NPs are crucial to utilize them in biological applications. We have achieved a stable ferrofluid in nonpolar solvent using SPIONs with an average size of 8 nm for magnetic hyperthermia applications.
MP-9.038 Hematopoietic Stem-Cell Transplantation for Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma MP-9.039 Hematopoietic Stem-Cell Transplantation for Chronic Myelogenous Leukemia MP-9.040 Hematopoietic Stem-Cell Transplantation for Acute Myeloid Leukemia MP-9.041 Hematopoietic Stem-C

Autologous hematopoietic stem-cell transplantation is considered investigational as initial treatment of lowor intermediate-risk neuroblastoma, initial treatment of lowor intermediaterisk Ewing sarcoma, and for other solid tumors of childhood including, but not limited, to the following as there is insufficient evidence to support a conclusion concerning the health outcomes or benefits associated with this procedure:
A 3-Gb/s Single-LED OFDM-Based Wireless VLC Link Using a Gallium Nitride $\mu{\rm LED}$

This letter presents a visible light communication (VLC) system based on a single 50- μm gallium nitride light emitting diode (LED). A device of this size exhibits a 3-dB modulation bandwidth of at least 60 MHz - significantly higher than commercially available white lighting LEDs. Orthogonal frequency division multiplexing is employed as a modulation scheme. This enables the limited modulation bandwidth of the device to be fully used. Pre- and postequalization techniques, as well as adaptive data loading, are successfully applied to achieve a demonstration of wireless communication at speeds exceeding 3 Gb/s. To date, this is the fastest wireless VLC system using a single LED.
Structural basis for the NAD‐hydrolysis mechanism and the ARTT‐loop plasticity of C3 exoenzymes

C3‐like exoenzymes are ADP‐ribosyltransferases that specifically modify some Rho GTPase proteins, leading to their sequestration in the cytoplasm, and thus inhibiting their regulatory activity on the actin cytoskeleton. This modification process goes through three sequential steps involving NAD‐hydrolysis, Rho recognition, and binding, leading to Rho ADP‐ribosylation. Independently, three distinct residues within the ARTT loop of the C3 exoenzymes are critical for each of these steps. Supporting the critical role of the ARTT loop, we have shown previously that it adopts a distinct conformation upon NAD binding. Here, we present seven wild‐type and ARTT loop‐mutant structures of C3 exoenzyme of Clostridium botulinum free and bound to its true substrate, NAD, and to its NAD‐hydrolysis product, nicotinamide. Altogether, these structures expand our understanding of the conformational diversity of the C3 exoenzyme, mainly within the ARTT loop.
The Evolution of Conflict under Inertia

In Norman (2003), the introduction of individual strategy switching costs, and thus inertia, into stochastic evolutionary coordination games was found inter alia to strengthen the mixed-strategy equilibrium as a short- to medium-run equilibrium. This paper considers the impact of such switching costs on the conflict scenario of Hawk-Dove games. The "attractive" mixed-strategy equilibrium of Hawk-Dove games represents a far better candidate for long-run equilibrium than its unstable counterpart in coordination games, and yet robust selection results have proved elusive, with conditions on the selection dynamics generally being required. Such a condition remains a necessity in the switching cost model with state-independent mutations. However, a more realistic model of state-dependent mutations driven by stochastic switching costs overcomes this problem, and identifies a threshold mean switching cost, above which the mixed-strategy equilibrium is selected in the long run for a wide class of switching cost distributions.
Prevalence and Progression of Subclinical Atherosclerosis in Younger Adults With Low Short-Term but High Lifetime Estimated Risk For Cardiovascular Disease: The Coronary Artery Risk Development in Young Adults Study and Multi-Ethnic Study of Atherosclerosis

Background— We hypothesized that individuals with low 10-year but high lifetime cardiovascular disease risk would have a greater burden of subclinical atherosclerosis than those with low 10-year but low lifetime risk. Methods and Results— We included 2988 individuals ≤50 years of age at examination year 15 from the Coronary Artery Risk Development in Young Adults (CARDIA) study and 1076 individuals ≤50 of age at study entry from the Multi-Ethnic Study of Atherosclerosis (MESA). The 10-year risk and lifetime risk for cardiovascular disease were estimated for each participant, permitting stratification into 3 groups: low 10-year (<10%)/low lifetime (<39%) risk, low 10-year (<10%)/high lifetime risk (≥39%), and high 10-year risk (≥10%) or diagnosed diabetes mellitus. Baseline levels and change in levels of subclinical atherosclerosis (coronary artery calcium or carotid intima-media thickness) were compared across risk strata. Among participants with low 10-year risk (91% of all participants) in CARDIA, those with a high lifetime risk compared with low lifetime risk had significantly greater common (0.83 versus 0.80 mm in men; 0.79 versus 0.75 mm in women) and internal (0.85 versus 0.80 mm in men; 0.80 versus 0.76 mm in women) carotid intima-media thickness, higher coronary artery calcium prevalence (16.6% versus 9.8% in men; 7.1% versus 2.3% in women), and significantly greater incidence of coronary artery calcium progression (22.3% versus 15.4% in men; 8.7% versus 5.3% in women). Similar results were observed in MESA. Conclusions— Individuals with low 10-year but high lifetime risk have a greater subclinical disease burden and greater incidence of atherosclerotic progression compared with individuals with low 10-year and low lifetime risk, even at younger ages.
Factors That Influence the Social Dimension of Alignment Between Business and Information Technology Objectives

The establishment of strong alignment between information technology (IT) and organizational objectives has consistently been reported as one of the key concerns of information systems managers. This paper presents findings from a study which investigated the influence of several factors on the social dimension of alignment within 10 business units in the Canadian life insurance industry. The social dimension of alignment refers 'Lynda M. Applegate was the accepting senior editor for this paper. to the state in which business and IT executives understand and are committed to the business and IT mission, objectives, and plans. The research model included four factors that would potentially influence alignment: (1) shared domain knowledge between business and IT executives, (2) IT implementation success, (3) communication between business and IT executives, and (4) connections between business and IT planning processes. The outcome, alignment, was operationalized in two ways: the degree of mutual understanding of current objectives (shortterm alignment) and the congruence of IT vision (long-term alignment) between business and IT executives. A total of 57 semi-structured interviews were held with 45 informants. Written business and IT strategic plans, minutes from IT steering committee meetings, and other strategy documents were collected and analyzed from each of the 10 business units. All four factors in the model (shared domain knowledge, IT implementation success, communication between business and IT executives, and connections between business and IT planning) were found to influence short-term alignment. Only shared domain knowledge was found to influence long-term alignment A new factor, strategic business plans, was found to influence both short and long-term alignment. MIS Quarterly Vol. 24 No. 1, pp. 81-113/March 2000 81 I~~~~~fl This content downloaded from 207.46. 13.115 on Sat, 08 Oct 2016 04:53:48 UTC All use subject to http://about.jstor. org/terms Reich & Benbasat/Alignment Between Business and IT Objectives The findings suggest that both practitioners and researchers should direct significant effort toward understanding shared domain knowledge, the factor which had the strongest influence on the alignment between IT and business executives. There is also a call for further research into the creation of an IT vision.
Fine mapping and candidate gene prediction of the photoperiod and thermo-sensitive genic male sterile gene pms1(t) in rice

Pei’ai64S, an indica sterile variety with photoperiod and thermo-sensitive genic male sterile (PTGMS) genes, has been widely exploited for commercial seed production for “two-line” hybrid rice in China. One PTGMS gene from Pei’ai64S, pms1(t), was mapped by a strategy of bulked-extreme and recessive-class approach with simple sequence repeat (SSR) and insert and deletion (In-Del) markers. Using linkage analysis for the F2 mapping population consisting of 320 completely male sterile individuals derived from a cross between Pei’ai64S and 93-11 (indica restorer) lines, the pms1(t) gene was delimited to the region between the RM21242 (0.2 cM) and YF11 (0.2 cM) markers on the short arm of chromosome 7. The interval containing the pms1(t) locus, which was co-segregated with RM6776, is a 101.1 kb region based on the Nipponbare rice genome. Fourteen predicted loci were found in this region by the Institute for Genomic Research (TIGR) Genomic Annotation. Based on the function of the locus LOC_Os07g12130 by bioinformatics analysis, it is predicted to encode a protein containing a Myb-like DNA-binding domain, and may process the transcript with thermosensory response. The reverse transcription-polymerase chain reaction (RT-PCR) results revealed that the mRNA levels of LOC_Os07g12130 were altered in different photoperiod and temperature treatments. Thus, the LOC_Os07g12130 locus is the most likely candidate gene for pms1(t). These results may facilitate not only using the molecular marker assisted selection of PTGMS genes, but also cloning of the pms1(t) gene itself.
Puzzle facade: a site-specific urban technological intervention

Media façades are becoming part of our urban landscapes, challenging media artists and designers to create content for them. The diversity of resolution and spatial properties of these façades hasn't stopped content creators to adapt their projects to multiple media façades with significant different resolution, shapes, surroundings and social environment. \ In this paper we introduce Puzzle Facade as an example of an urban technological intervention that has a strong connection with the spatial properties of the media façade it was conceived for, the media façade of the Ars Electronica Center.