Miracle-dz/UniFAR-FTUs huggingface dataset:
Histone deacetylase 10 promotes autophagy-mediated cell survival

Significance Resistance to chemotherapy is one of the major challenges in oncology. Neuroblastoma is the most common extracranial solid tumor in childhood, and the successful response of high-risk patients to chemotherapy remains poor. Our work showed that the so far poorly studied histone deacetylase (HDAC)10 promotes autophagy-mediated cell survival and signals poor outcome in independent high-risk patient cohorts. Inhibition of HDAC10 sensitized tumor cells for cytotoxic drug treatment. These results offer HDAC10 as a potential biomarker for treatment response of high-risk tumors and open new avenues for developing selective treatment strategies to bypass drug resistance of these tumors. Tumor cells activate autophagy in response to chemotherapy-induced DNA damage as a survival program to cope with metabolic stress. Here, we provide in vitro and in vivo evidence that histone deacetylase (HDAC)10 promotes autophagy-mediated survival in neuroblastoma cells. We show that both knockdown and inhibition of HDAC10 effectively disrupted autophagy associated with sensitization to cytotoxic drug treatment in a panel of highly malignant V-MYC myelocytomatosis viral-related oncogene, neuroblastoma derived-amplified neuroblastoma cell lines, in contrast to nontransformed cells. HDAC10 depletion in neuroblastoma cells interrupted autophagic flux and induced accumulation of autophagosomes, lysosomes, and a prominent substrate of the autophagic degradation pathway, p62/sequestosome 1. Enforced HDAC10 expression protected neuroblastoma cells against doxorubicin treatment through interaction with heat shock protein 70 family proteins, causing their deacetylation. Conversely, heat shock protein 70/heat shock cognate 70 was acetylated in HDAC10-depleted cells. HDAC10 expression levels in high-risk neuroblastomas correlated with autophagy in gene-set analysis and predicted treatment success in patients with advanced stage 4 neuroblastomas. Our results demonstrate that HDAC10 protects cancer cells from cytotoxic agents by mediating autophagy and identify this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival. Moreover, these results propose a promising way to considerably improve treatment response in the neuroblastoma patient subgroup with the poorest outcome.
Learning with few bits on small-scale devices: From regularization to energy efficiency

The implementation of Machine Learning (ML) algorithms on stand-alone small-scale devices allows the incorporation of new services and advanced functionalities without the need of resorting to remote com- puting systems. Despite having undeniable advantages with respect to conventional general-purpose devices, e.g. in terms of cost/performance ratios, small-scale systems suffer of issues related to their resource-limited nature, like limited battery capacity and processing power. In order to deal with such limitations, we propose to merge local Rademacher Complex- ities and bit-based hypothesis spaces to build thrifty models, which can be effectively implemented on small-scale resource-limited devices. Exper- iments, carried out on a smartphone in a Human Activity Recognition application, show the benefits of the proposed approach in terms of model accuracy and battery duration.
A Real Time Interactive Dynamic Light Field Transmission System

The ability to interactively and seamlessly roam in the scenario while watching a video through IP network is an exciting visual experience. In this work, we implemented a 3D TV system with real-time data acquisition, compression, Internet transmission, light field rendering, and free-viewpoint control of dynamic scenes. Our system consists of an 8times8 light field camera array, 16 producer PCs, a streaming server system and several clients. Multiple video streams are coded in a real time manner that each client can freely selects the streams for novel view rendering. Also, our system minimize the per-user transmission bit rate while maintaining multi-view simul-switching ability for each user. We believe that this is the first real-time Internet streaming system that can simultaneously guarantee real time free-view point control, data storage and support arbitrary number of users. The average transmission bit rate for end user is lower than 2 Mbps which is suitable for the broadband IP network
pH Control in Fog and Rain in East Asia: Temporal Advection of Clean Air Masses to Mt. Bamboo, Taiwan

Fog and rain was collected during an 18-day period in January 2011 at Mt. Bamboo, northern Taiwan. Almost 300 hourly fog samples and 16 daily rain samples were taken. One single fog sample (pH 3.17) was influenced by local volcanic activity, otherwise the pH ranged from 3.23 to 6.41 in fog and from 3.59 to 6.31 in rain. All the respective air masses arrived from the northeast, but exhibited two distinct groups: Group_1 had high concentrations of all ions (median interquartile range of total ion concentrations 3200–6200 µeq.·L−1) and low pHs (median 3.52), the respective air masses had travelled over densely populated and industrialized regions of mainland China. Group_2 was from air masses with long travel times over the ocean and relatively low total ion concentrations (80–570 µeq.·L−1) and higher pHs (median 4.80). The cleanest samples are among the cleanest reported in the literature of worldwide fog and rain. In both groups, the pH was governed by the balance of sulfate, nitrate, ammonium, and, in some cases, calcium. The variability of these ions was higher than the variability of 10−pH, which shows that the pH is a rather robust parameter in contrast to its drivers such as non-sea-salt sulfate.
Behavioral Responses in Structured Populations Pave the Way to Group Optimality*

An unresolved controversy regarding social behaviors is exemplified when natural selection might lead to behaviors that maximize fitness at the social-group level but are costly at the individual level. Except for the special case of groups of clones, we do not have a general understanding of how and when group-optimal behaviors evolve, especially when the behaviors in question are flexible. To address this question, we develop a general model that integrates behavioral plasticity in social interactions with the action of natural selection in structured populations. We find that group-optimal behaviors can evolve, even without clonal groups, if individuals exhibit appropriate behavioral responses to each other’s actions. The evolution of such behavioral responses, in turn, is predicated on the nature of the proximate behavioral mechanisms. We model a particular class of proximate mechanisms, prosocial preferences, and find that such preferences evolve to sustain maximum group benefit under certain levels of relatedness and certain ecological conditions. Thus, our model demonstrates the fundamental interplay between behavioral responses and relatedness in determining the course of social evolution. We also highlight the crucial role of proximate mechanisms such as prosocial preferences in the evolution of behavioral responses and in facilitating evolutionary transitions in individuality.
The BPS spectra of gauge theories in two and four dimensions

We study = (2,2) supersymmetric abelian gauge theories in two dimensions. The exact BPS spectrum of these models is shown to coincide with the spectrum of massive hypermultiplets of certain = 2 supersymmetric gauge theories in four dimensions. A special case of these results involves a surprising connection between four-dimensional = 2 SQCD with N colours and N$>Nf>N flavours at the root of the baryonic Higgs branch and the supersymmetric CP2N−Nf−1 σ-model in two dimensions. This correspondence implies a new prediction for the strong-coupling spectrum of the four-dimensional theory.
Reversible transdifferentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro

Blood vascular cells and lymphatic endothelial cells (BECs and LECs, respectively) form two separate vascular systems and are functionally distinct cell types or lineages with characteristic gene expression profiles. Interconversion between these cell types has not been reported. Here, we show that in conventional in vitro angiogenesis assays, human BECs of fetal or adult origin show altered gene expression that is indicative of transition to a lymphatic-like phenotype. This change occurs in BECs undergoing tubulogenesis in fibrin, collagen or Matrigel assays, but is independent of tube formation per se, because it is not inhibited by a metalloproteinase inhibitor that blocks tubulogenesis. It is also reversible, since cells removed from 3D tubules revert to a BEC expression profile upon monolayer culture. Induction of the lymphatic-like phenotype is partially inhibited by co-culture of HUVECs with perivascular cells. These data reveal an unexpected plasticity in endothelial phenotype, which is regulated by contact with the ECM environment and/or cues from supporting cells.
The impact of mission profile models on the predicted lifetime of IGBT modules in the modular multilevel converter

The reliability aspect study of Modular Multilevel Converter (MMC) is of great interest in industry applications, such as offshore wind. Lifetime prediction of key components is an important tool to design MMC with fulfilled reliability specifications. While many efforts have been made to the lifetime prediction of IGBT modules in renewable energy applications by considering long-term varying operation conditions (i.e., mission profile), the justifications of using the associated mission profiles are still missed. This paper investigates the impact of mission profile data resolutions and electrical power modeling methods on the estimated lifetime of IGBT modules in an MMC for offshore wind power application. In a 30 MW MMC case study, an annual wind speed profile with a resolution of 1 s/data, 10 minute/data, and 1 hour/data are considered, respectively. A method to re-generate higher resolution wind speed data from lower resolution data is introduced as well. Based on the wind speed data, IEC 61400-12-1 power curve model and a wind speed-power stochastic model are compared as well. Five mission profile modeling scenarios are compared in terms of the predicted lifetime of the IGBT modules used in the MMC, resulting in significant differences. The study serves as a first step to quantify the impact of mission profile modeling on lifetime prediction, and to provide a guideline on mission profile collection for the presented application.
Deferiprone in the treatment of transfusion-dependent thalassemia: a review and perspective

Deferiprone is an orally active iron chelator which has emerged from an extensive search for new treatment of iron overload. Comparative studies have shown that at comparable doses deferiprone may be as effective as deferoxamine in removing body iron. Retrospective and prospective studies have shown that deferiprone monotherapy is significantly more effective than deferoxamine in improving myocardial siderosis in thalassemia major. Agranulocytosis is the most serious side effect associated with the use of deferiprone, occurring in about 1% of the patients. More common but less serious side effects are gastrointestinal symptoms, arthralgia, zinc deficiency, and fluctuating transaminases levels. Deferiprone can be used in combination with desferrioxamine. This regimen of chelation is tolerable and attractive for patients unable to comply with standard deferoxamine infusions or with inadequate response to deferiprone alone. Combination therapy has been effectively used in the management of severe cardiac siderosis.
Molecular diagnosis of toxoplasmosis in immunocompromised patients

Purpose of review Toxoplasmosis in immunocompromised patients is associated with a high mortality rate. Molecular techniques are important tools to diagnose acute disease in immunocompromised patients, but there are various methods with variable efficiency. Some of them have been validated for the diagnosis of congenital toxoplasmosis, but the impact of their use has not been evaluated in immunocompromised patients. Recent findings Toxoplasmosis is of increasing importance in non-HIV immunocompromised patients. In addition, the picture of disease shows greater severity in South America, both in immunocompetent study participants and in congenitally infected infants. These epidemiological differences could influence the sensitivity of diagnostic methods. This review analyzes recent data on molecular diagnosis and compares them with older ones, in light of progress gained in molecular techniques and of recent epidemiological findings. Most recent studies were conducted in South America and used PCR targeting the B1 gene. PCR on blood could allow diagnosing a significant proportion of patients with ocular toxoplasmosis in Brazil. Summary Quantitative PCR methods with specific probes should be used to improve sensitivity and warrant specificity. Performance of quantitative PCR targeting the repeated 529 bp sequence for the diagnosis of toxoplasmosis in immunocompromised patients needs evaluation in field studies in South America and in western countries.
Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit

The adhesive and signaling functions of integrins are regulated through their cytoplasmic domains. We identified a novel 111 residue polypeptide, designated beta 3-endonexin, that interacted with the cytoplasmic tail of the beta 3 integrin subunit in a yeast two-hybrid system. This interaction is structurally specific, since it was reduced by 64% by a point mutation in the beta 3 cytoplasmic tail (S752-->P) that disrupts integrin signaling. Moreover, this interaction is integrin subunit specific since it was not observed with the cytoplasmic tails of the alpha IIb, beta 1, or beta 2 subunits. beta 3- Endonexin fusion proteins bound selectively to detergent-solubilized beta 3 from platelets and human umbilical vein endothelial cells, and beta 3-endonexin mRNA and protein were detected in platelets and other tissues. A related mRNA encoded a larger polypeptide that failed to bind to beta integrin tails. The apparent specificity of beta 3- endonexin for the beta 3 integrin subunit suggests potential mechanisms for selective modulation of integrin functions.
Spirituality is associated with less treatment regret in men with localized prostate cancer

Some patients with prostate cancer regret their treatment choice. Treatment regret is associated with lower physical and mental quality of life. We investigated whether, in men with prostate cancer, spirituality is associated with lower decisional regret 6 months after treatment and whether this is, in part, because men with stronger spiritual beliefs experience lower decisional conflict when they are deciding how to treat their cancer.
WLC29-2: Performance of Wireless LAN Access Methods in Multicell Environments

In this paper, we address the issue of evaluating performance of wireless LANs in multicell scenarios. We try to understand the complex behavior of the DCF (distributed coordination function) access method defined in the IEEE 802.11 standard [1] and its modifications proposed for improving performance: slow decrease [2], asymptotically optimal backoff [3], and idle sense [4]. We analyze the influence of overlapping cells and large multicell environments on their performance. Our results show that the IEEE 802.11 DCF and its two modifications (slow decrease and AOB) exhibit important unfairness between stations close to the access point and those near the border of a neighbor cell. Idle Sense performs much better: it provides much better fairness than the IEEE 802.11 DCF and its modifications. It also obtains the highest throughput when stations adapt their bit rate to channel conditions.
Effect of Pregnancy on the Levels of Blood Cadmium, Lead, and Mercury for Females Aged 17–39 Years Old: Data from National Health and Nutrition Examination Survey 2003–2010

Data from the National Health and Nutrition Examination survey for the years 2003–2010 were used (n = 4700) to evaluate the effect of age, parity, body mass index (BMI), race/ethnicity, pregnancy, iron (Fe) storage status, smoking status, and fish/shellfish consumption on the levels of blood cadmium (Cd), lead (Pb), and total mercury (Hg)for females aged 17–39yr old. Regression analysis was used to fit models for each of the three metals. For all three metals, age was positively and BMI was negatively associated with levels of these metals in blood. Smokers had statistically significantly higher levels of Cd and Pb irrespective of race/ethnicity and Fe storage status as compared to nonsmokers. Novel to this study, pregnancy was found to be associated with significantly lower levels of Cd, Pb, and Hg irrespective of race/ethnicity and Fe storage status as compared to nonpregnant females. It is conceivable that pregnancy may thus accelerate clearance of these metals from blood. Fish/shellfish consumption was associated with higher levels of Hg but not with Cd levels.
Remote measurement of material properties from radiation force induced vibration of an embedded sphere.

A quantitative model is presented for a sphere vibrated by two ultrasound beams of frequency omega1 and omega2. Due to the interference of two sound beams, the radiation force has a dynamic component of frequency omega2-omega1. The radiation impedance and mechanical impedance of the sphere are then used to compute the vibration speed of the sphere. Vibration speed versus vibration frequency is measured by laser vibrometer on several spheres, both in water and in gel phantom. These experimental results are used to verify the model. This method can be used to estimate the material properties of the medium (e.g., shear modulus) surrounding the sphere.
The degrees of freedom of the K-pair-user full-duplex two-way interference channel with a MIMO relay

In a K-pair-user two-way interference channel (TWIC), 2K messages and 2K transmitters/receivers form a K-user IC in the forward direction (K messages) and another K-user IC in the backward direction which operate in full-duplex. All nodes may interact, or adapt inputs to past received signals. The optimal degrees of freedom (DoF, also known as the multiplexing gain) is known to be K [1]: full-duplex operation doubles the DoF, but interaction does not further increase the DoF. In this paper, we characterize the DoF of the K-pair-user TWIC with a MIMO, full-duplex relay. If the relay is noncausal/ instantaneous (at time k forwards a function of its received signals up to time k) and has 2K antennas, we demonstrate a one-shot scheme where the relay mitigates all interference to achieve the interference-free 2K DoF. In contrast, if the relay is causal (at time k forwards a function of its received signals up to time k - 1), we show that a full-duplex MIMO relay cannot increase the DoF of the K-pair-user TWIC beyond K, as if no relay or interaction is present.
Coordination and multi-relational modelling: 'X and X' revisited

A relational model of language is developed which unifies traditional features of X-bar theory with lexicon based modelling. It is argued that such a model provides the appropriate basis for handling problematic cases of non-constituent coordination and gapping. A prototype implementation is discussed on the basis of six representative examples, corpus-based.
Intolerance of uncertainty, depression, and anxiety: the moderating and mediating roles of rumination.

OBJECTIVES This study examined rumination as a moderator and mediator between intolerance of uncertainty (IU) and depression and anxiety symptoms. DESIGNS The study was a cross sectional study. Survey data were collected from 332 undergraduate students at a large Midwestern university. RESULTS The results from hierarchical analyses supported the moderator role of rumination. A high level of rumination enhanced the association between IU and depression symptoms. In addition, both high and low levels of rumination strengthened the relation between IU and anxiety symptoms. Results from structural equation modeling analyses indicated that rumination fully mediated the relation between IU and depression symptoms, but only partially mediated the association between IU and anxiety symptoms. CONCLUSIONS The results supported rumination as a moderator and mediator in the association between IU and depression and anxiety symptoms. Future research and practical implications are discussed.
Optimization and Analysis of Distributed Averaging With Short Node Memory

Distributed averaging describes a class of network algorithms for the decentralized computation of aggregate statistics. Initially, each node has a scalar data value, and the goal is to compute the average of these values at every node (the so-called average consensus problem). Nodes iteratively exchange information with their neighbors and perform local updates until the value at every node converges to the initial network average. Much previous work has focused on algorithms where each node maintains and updates a single value; every time an update is performed, the previous value is forgotten. Convergence to the average consensus is achieved asymptotically. The convergence rate is fundamentally limited by network connectivity, and it can be prohibitively slow on topologies such as grids and random geometric graphs, even if the update rules are optimized. In this paper, we provide the first theoretical demonstration that adding a local prediction component to the update rule can significantly improve the convergence rate of distributed averaging algorithms. We focus on the case where the local predictor is a linear combination of the node's current and previous values (i.e., two memory taps), and our update rule computes a combination of the predictor and the usual weighted linear combination of values received from neighboring nodes. We derive the optimal mixing parameter for combining the predictor with the neighbors' values, and conduct a theoretical analysis of the improvement in convergence rate that can be achieved using this acceleration methodology. For a chain topology on N nodes, this leads to a factor of N improvement over standard consensus, and for a two-dimensional grid, our approach achieves a factor of ¿N improvement.
Systematic exploitation of data parallelism in hardware synthesis of DSP applications

We describe an approach that we have explored for low-power synthesis and optimization of image, video, and digital signal processing (DSP) applications. In particular, we consider the systematic exploitation of data parallelism across the operations of an application dataflow graph when synthesizing a dedicated hardware implementation. Data parallelism occurs commonly in DSP applications, and provides flexible opportunities to increase throughput or lower power consumption. Exploiting this parallelism in a dedicated hardware implementation comes at the expense of increased resource requirements, which must be balanced carefully when applying the technique in a design tool. We propose a high level synthesis algorithm to determine the data parallelism factor for each computation, and, based on the area and performance trade-off curve, design an efficient hardware representation of the dataflow graph. For performance estimation, our approach uses a cyclostatic dataflow intermediate representation of the hardware structure under synthesis. We then apply an automatic hardware generation framework to build the actual circuit.
Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited

Activation of Cdk1 is rapid and switch-like due to positive feedback mechanisms. When Cdk1 is fully on, cells are capable of M-to-G1 transition. Inhibition of positive feedback prevents rapid Cdk1 activation and induces a mitotic “collapse” phenotype characterized by the dephosphorylation of mitotic substrates without cyclin B proteolysis.