Miracle-dz/UniFAR-FTUs huggingface dataset:
Work-Related Musculoskeletal Disorders and Risk Factors among Chinese Medical Staff of Obstetrics and Gynecology

Medical staff in the department of obstetrics and gynecology are a group of professionals reportedly at high risk of work-related musculoskeletal disorders (WMSD), however, little is known about the current status of this problem in China. The aim of this study was to investigate prevalence and risk factors of work-related musculoskeletal disorders among this population in China. A self-developed questionnaire was distributed to 1017 obstetrics and gynecology practitioners to collect information on musculoskeletal symptoms and relevant factors. Prevalence and severity of work-related musculoskeletal disorders in different parts of the body were calculated and the relationship between personal and ergonomic factors and work-related musculoskeletal disorders was analyzed using Chi-square test and unconditional logistic regression models. The results indicated a high prevalence of 85.5% among the subjects, with the shoulder (n = 575, 62.0%), neck (n = 560, 60.3%) and lower back (n = 504, 54.3%) being the three most affected regions. Individual, postural, work-environmental as well as psychosocial factors were recognized to be associated with WMSDs in different body parts. Therefore, attention must be given to the problem of musculoskeletal disorders among Chinese obstetrics and gynecology staff. It is recommended to develop good life habits, improve work environment, adjust work organization as well as train on proper postures in their daily operation.
Draft Genome Sequence of Mycobacterium mucogenicum Strain CSUR P2099

ABSTRACT Mycobacterium mucogenicum is a rapid-growing, nontuberculosis Mycobacterium species. The draft genome of M. mucogenicum CSUR P2099 comprises 6,210,127 bp exhibiting a 67.2% G+C content, 6,003 protein-coding genes, and 91 predicted RNA genes.
Gait Analysis in Orthopedic Foot and Ankle Surgery—Topical Review, Part 1

Gait analysis, the systematic study of human walking, is a field that has been studied for well over 100 years. With the technological and scientific advancements of the last several decades, there has been substantial improvement in our understanding of the mechanics of human walking. Particularly important has been the advancement in understanding of the differences between normal and pathological gait. The purpose of this paper is to review the principles of gait analysis, with a particular focus on the underlying methods and science. This will assist orthopedic foot and ankle surgeons in better understanding the methods and meaning of gait research and the publications that commonly appear in the orthopedic foot and ankle surgery literature. Level of Evidence: Level V, expert opinion.
Diaquabis(nitrato-κ2 O,O′)bis(pyrazine-2-carboxamide-κN 4)cadmium–pyrazine-2-carboxamide (1/2)

In the title compound, [Cd(NO3)2(C5H5N3O)2(H2O)2]·2C5H5N3O, the CdII cation is located on a twofold rotation axis and is coordinated by two pyrazine-2-carboxamide ligands and two water molecules and chelated by two nitrate anions in a distorted square-antiprismatic geometry. Extensive intermolecular N—H⋯O, N—H⋯N, O—H⋯O and O—H⋯N hydrogen bonds, as well as weak intermolecular C—H⋯N and C—H⋯O interactions occur in the crystal. π–π stacking between between pyrazine rings of coordinating ligands and lattice molecules [centroid–centroid distance = 3.5669 (14) Å] may further stabilize the structure.
A C ONTEXTUAL D ISCRETIZATION FRAMEWORK FOR COMPRESSING R ECURRENT N EURAL N ETWORKS

In this paper, we address the issue of training Recurrent Neural Networks with binary weights and introduce a novel Contextualized Discretization (CD) framework and showcase its effectiveness across multiple RNN architectures and two disparate tasks. We also propose a modified GRU architecture that allows harnessing the CD method and reclaim the exclusive usage of weights in {−1, 1}, which in turn reduces the number of power-two bit multiplications from O(n) to O(n).
Distributed spatial–temporal precoding with limited feedback in MIMO multi‐relay systems

Precoding techniques can be introduced into multi‐relay systems due to the similarity between cooperative communication systems and traditional multi‐input–multi‐output (MIMO) systems. In this paper, a channel state information (CSI) feedback scheme based on the zero‐forcing (ZF) relaying protocol is proposed at first, where the information of relaying channel and noise related to each relay node can be compressed into two positive real parameters. Then, based on the proposed feedback scheme, the singular‐vector‐based local temporal precoder is presented at the source node through two continuous transmitted vectors, which is termed as distributed spatial–temporal precoding (DSTP). Moreover, various spatial data rates can be conveniently supported by DSTP. Based on the analysis on DSTP, it is better that the number of data streams is not larger than the number of antennas equipped at the source node. The unitary DSTP with the proposed feedback scheme outperforms not only the close‐loop direct transmission but also the simple ZF relaying method. Copyright © 2010 John Wiley & Sons, Ltd.
NEW PRODUCTS AND ADVANCEMENTS IN 3-D MODELLING PROTOCOLS BASED ON STUDIES IN THICK DRIFT AREAS IN ONTARIO , CANADA

The May, 2000 tragedy at Walkerton Ontario, which resulted in the loss of seven lives and thousands becoming sick from drinking contaminated municipally-supplied water, focused the attention of both the public and government regulators on the importance of protecting and preserving the quality and sustainability of the provincial groundwater resource. A key recommendation in the Walkerton Inquiry report (now legislated by the provincial Clean Water Act) was the implementation of watershed-based source water protection plans for the province that are designed to protect human health by ensuring that current and future sources of drinking water are protected from potential contamination and depletions (O’Connor 2002). An important component of these source water protection plans is the development of 3-D regional groundwater flow models that are based on a sound understanding of the properties and 3-D architecture of subsurface geologic materials. In 2002, the Ontario Geological Survey (OGS) initiated a pilot project of 3-D mapping of thick Quaternary deposits in the Waterloo Region of southwestern Ontario. This was followed by similar studies in the Barrie area of central Ontario, where the Oro Moraine is situated, and the BrantfordWoodstock area of southwestern Ontario. All of these studies will provide conservation authorities and other client groups with the tools necessary for constructing reliable groundwater flow models.
Insulin Resistance and Cognitive Functions in a Sample of Prefrail, Frail and Non-Frail Elderly

Aim: To study the association between Insulin Resistance (IR) and Glycosylated hemoglobin (HbA1c) and cognition in frail, pre-frail and non-frail elderly. Method: A case control study was conducted on 85 subjects: 60 cases (37 frail and 23 pre-frail subjects) and 25 controls. All subjects underwent comprehensive geriatric assessment including a battery of cognitive tests. Laboratory data included Serum insulin levels, Fasting Blood Sugar, Insulin like Growth Factor-1, C-Reactive Protein (CRP) and HbA1c. Results: Among the pre-frail subjects, Homeostasis Model of Assessment-Insulin resistance (HOMA-IR) and insulin level were positively correlated with Digit Span Backward (DSB) (p = 0.012 and 0.045 respectively). HbA1c was positively correlated with Contrast Programming (CP) (p = 0.01). Controls showed a positive correlation between HOMA-IR and CP, DSB and Mini-Mental Status Examination (P = 0.009, 0.03 and 0.002 respectively). There was no significant correlation in the frail group. Conclusion: In the studied sample, higher insulin, HbA1c, and IR were associated with better cognitive functions in prefrail elderly, and were not associated with worse cognition in frail elderly.
Time-Dependent Diffusion MRI in Cancer: Tissue Modeling and Applications

In diffusion weighted imaging (DWI), the apparent diffusion coefficient has been recognized as a useful and sensitive surrogate for cell density, paving the way for non-invasive tumor staging, and characterization of treatment efficacy in cancer. However, microstructural parameters, such as cell size, density and/or compartmental diffusivities affect diffusion in various fashions, making of conventional DWI a sensitive but non-specific probe into changes happening at cellular level. Alternatively, tissue complexity can be probed and quantified using the time dependence of diffusion metrics, sometimes also referred to as temporal diffusion spectroscopy when only using oscillating diffusion gradients. Time-dependent diffusion (TDD) is emerging as a strong candidate for specific and non-invasive tumor characterization. Despite the lack of a general analytical solution for all diffusion times / frequencies, TDD can be probed in various regimes where systems simplify in order to extract relevant information about tissue microstructure. The fundamentals of TDD are first reviewed (a) in the short time regime, disentangling structural and diffusive tissue properties, and (b) near the tortuosity limit, assuming weakly heterogeneous media near infinitely long diffusion times. Focusing on cell bodies (as opposed to neuronal tracts), a simple but realistic model for intracellular diffusion can offer precious insight on diffusion inside biological systems, at all times. Based on this approach, the main three geometrical models implemented so far (IMPULSED, POMACE, VERDICT) are reviewed. Their suitability to quantify cell size, intra- and extracellular spaces (ICS and ECS) and diffusivities are assessed. The proper modeling of tissue membrane permeability – hardly a newcomer in the field, but lacking applications - and its impact on microstructural estimates are also considered. After discussing general issues with tissue modeling and microstructural parameter estimation (i.e. fitting), potential solutions are detailed. The in vivo applications of this new, non-invasive, specific approach in cancer are reviewed, ranging from the characterization of gliomas in rodent brains and observation of time-dependence in breast tissue lesions and prostate cancer, to the recent preclinical evaluation of new treatments efficacy. It is expected that clinical applications of TDD will strongly benefit the community in terms of non-invasive cancer screening.
Neuromuscular and metabolic responses to high-intensity intermittent cycling protocols with different work-to-rest ratios.

PURPOSE To investigate the effects of work-to-rest-ratio manipulation on neuromuscular and metabolic responses during 2 high-intensity intermittent training (HIT) protocols to exhaustion. Since different exercise durations were expected, the authors hypothesized that the protocol registering a longer duration would have a more pronounced effect on neuromuscular responses, while the other would challenge the cardiopulmonary system more. METHODS Thirteen competitive cyclists (age 19 ± 2 y) performed a preliminary incremental test to identify their maximal power output and 2 intermittent protocols to exhaustion (40:20s and 30:30s) at a fixed work rate of 135%Pmax interspersed by passive recovery. Surface electromyographic (sEMG) parameters (including muscle-fiber conduction velocity), cardiopulmonary parameters, and blood lactate concentration [La-] were recorded. RESULTS Time to exhaustion and total work were significantly higher for the 30:30s (38 ± 13 min, 495 ± 161 kJ) than for the 40:20s (10 ± 3 min, 180 ± 51 kJ). No differences were found in sEMG parameters for the 2 protocols. Mean and peak values of VO2, heart rate, ventilatory parameters (except for the peak value of respiratory frequency), and [La-] were significantly higher in the 40:20s than in the 30:30s. CONCLUSIONS These results do not support the hypothesis that a longer time spent at high intensity has a more pronounced effect on neuromuscular responses, as no differences in EMG parameters were found in the 2 HIT protocols. Regarding metabolic responses, while the 40:20s led to maximal values of VO2, [La-], and ventilatory parameters within a few minutes, the 30:30s allowed maintenance of moderately high values for a considerably longer period, especially for [La-] and ventilatory parameters.
Anatomy of the Laminar Organs of Commelina erecta (Commelinaceae)

Abstract A study was undertaken to compare the anatomy of the laminar floral parts with that of the spathes and leaves of Commelina erecta L. Each flower has two types of petals and two types of sepals. In contrast to the other organs, the petals have a completely open venation system whose vein endings consist solely of modified bundle-sheath cells. Bundle sheaths of leaves and spathes, but not the floral organs, contain sclerified cells for support. The high density of hook-shaped trichomes on the outer surface of the spathe and of glandular microhairs on the inner surface might indicate protective and secretory functions, respectively. Anomalous stomatal apparatuses are more common on floral organs than on spathes or leaves. Leaves and spathes appear to have a more detailed developmental program than sepals and petals.
The Cutaneous Microvascular Architecture of Human Diabetic Toe Studied by Corrosion Casting and Scanning Electron Microscopy Analysis

In this morphological study, we report on the three‐dimensional microvascular architecture constituting the toes of a patient affected by diabetic microangiopathy. We applied corrosion casting (CC) technique to the toes of a patient affected by Type 2 diabetes, who underwent surgery for explantation of inferior left limb due to necrotic processes of soft tissues. The toes of a foot traumatically explanted in a motorcycle accident were kept as controls. According to technical protocols, toes were injected with a low‐viscosity acrylic resin (Mercox) through the major digital artery, tissues were corroded in KOH solution (8%), and resulting casts processed for SEM observations. Already at low magnification, in diabetic toes, we found an impairment of the linear track‐like disposition of the vessels of plantar side, with signs of vascular disruption and obliterations, stopped resin, and leakages. Capillaries under the nail and a lot of vascular villi in eponychium and nail borders were damaged, and vascular regression phenomena acting on them were clearly visible. Resin leakages and impairment of normal vascular architecture were also observed in the root of the nail. This preliminary report represents only the first step for further investigations regarding morphological three‐dimensional appearance of diabetic microangiopathy. CC and scanning electron microscopy technique well documented these morphological modifications, highlighting on both structural and ultrastructural features of diabetic toes microvessels. In conclusion, our qualitative data try to better focus on the pathophysiological mechanisms involved in diabetic dermopathy and microangiopathy, proposing CC as useful method to investigate on them. Anat Rec 293:1639–1645, 2010. © 2010 Wiley‐Liss, Inc.
Supervised Restricted Boltzmann Machines

We propose in this paper the supervised restricted Boltzmann machine (sRBM), a unified framework which combines the versatility of RBM to simultaneously learn the data representation and to perform supervised learning (i.e., a nonlinear classifier or a nonlinear regressor). Unlike the current state-of-the-art classification formulation proposed for RBM in (Larochelle et al., 2012), our model is a hybrid probabilistic graphical model consisting of a distinguished generative component for data representation and a discriminative component for prediction. While the work of (Larochelle et al., 2012) typically incurs no extra difficulty in inference compared with a standard RBM, our discriminative component, modeled as a directed graphical model, renders MCMC-based inference (e.g., Gibbs sampler) very slow and unpractical for use. To this end, we further develop scalable variational inference for the proposed sRBM for both classification and regression cases. Extensive experiments on realworld datasets show that our sRBM achieves better predictive performance than baseline methods. At the same time, our proposed framework yields learned representations which are more discriminative, hence interpretable, than those of its counterparts. Besides, our method is probabilistic and capable of generating meaningful data conditioning on specific classes – a topic which is of current great interest in deep learning aiming at data generation.
Characteristics of premenopausal and postmenopausal women with acquired, generalized hypoactive sexual desire disorder: the Hypoactive Sexual Desire Disorder Registry for women

ObjectiveLittle is known about the natural history of hypoactive sexual desire disorder (HSDD). We examined the sociodemographic, relationship, help seeking, sexual function, and medical characteristics of women with a clinical diagnosis of generalized, acquired HSDD by menopause status. MethodsThis study was a cross-sectional baseline data analysis from the HSDD Registry for Women (N = 1,574, from 33 US clinical sites). HSDD was clinically diagnosed and confirmed. Validated measures of sexual function, relationship factors, and health, as well as newly developed questions on help seeking were assessed using the questionnaire. ResultsParticipants were predominantly married or living with a partner (81.7%) and represented a range of race/ethnic backgrounds and ages (mean ± SD, 42.9 ± 11.9 y). Most (56.8%) described their HSDD severity as “moderate to severe,” with 26.5% rating the problem severe. Nonetheless, most women (69.8%) reported being happy in their relationship, and 61.8% were satisfied with their partner communication. Postmenopausal women had lower Female Sexual Function Index total scores, indicating worse sexual function (14.0 ± 7.5) than premenopausal women (16.7 ± 6.8, P < 0.001), although both groups had similarly low scores on the sexual desire domain (3.4 ± 1.3 vs 3.3 ± 1.4). Less than half of the overall sample had sought professional help, among whom hormonal treatments had been used by 23.7% of postmenopausal women and by 7.6% of premenopausal women. ConclusionsMost women with HSDD were in long-term partner relationships with high levels of overall relationship satisfaction. Postmenopausal women were more likely to seek help for their disorder, despite similarly high levels of distress associated with HSDD. Further research is needed to examine treatment outcomes.
Cyclic-spectrum pulse shaping for increased nonlinear tolerance

We exploit excess spectrum of DWDM systems, where the Nyquist bandwidth of the optical signals is narrower than the channel spacing. Digitally generated cyclic-spectrum RZ shaping is shown to enhance nonlinear tolerance. Simulations show a 26% reach increase in a 7-channel DWDM PolMux 16QAM long-haul transmission.
An H1(Ph)-Coercive Discontinuous Galerkin Formulation for the Poisson Problem: 1D Analysis

Discontinuous Galerkin (DG) methods are finite element techniques for the solution of partial differential equations. They allow shape functions which are discontinuous across inter-element edges. In principle, DG methods are ideally suited for hp-adaptivity, as they handle nonconforming meshes and varying-in-space polynomial-degree approximations with ease. Recently, DG formulations for elliptic problems have been put in a general framework of analysis. Although clarifying basic properties, the analysis does not warrant a clear preference. Specifically, none of the conventional DG formulations possesses a bilinear form that is coercive (and continuous) on an infinite-dimensional broken Sobolev space. Rather, bilinear forms are only weakly coercive or defined on subspaces only and employ stabilization parameters that typically increase unboundedly as the subspace is expanded, e.g., if the polynomial degree is increased. For hp-adaptation, coercivity is a fundamental property: By the classical Lax-Milgram theorem, any conforming discretization of a coercive formulation is stable, i.e., discrete approximations are well-posed and have a unique solution, irrespective of the specifics of the underlying approximation space. In this work we consider the one-dimensional Poisson problem and present a generic consistent conventional DG formulation. We show that conventional DG formulations are necessarily noncoercive. Moreover, we presents a new symmetric DG formulation which contains nonconventional edge terms based on element Green's functions and the data local to the edges. We show that the new DG formulation is coercive on H1(Ph), the space of functions that are piecewise in the H1 Sobolev space. Furthermore, we show that the new DG formulation and the classical Galerkin formulation are equivalent, that is, in the infinite-dimensional case they yield the same solution.
Computer-assisted methods for assessing strain relatedness in Candida albicans by fingerprinting with the moderately repetitive sequence Ca3

When used to probe EcoRI-digested Candida albicans DNA, the moderately repetitive sequence Ca3 generated a Southern blot hybridization pattern which included 15 to 25 bands, depending upon the strain. The pattern was stable through 400 generations in each of three independent strains but variable between most of 46 unrelated tester strains, making it a very effective probe for discrimination between strains. Computer-assisted methods (Dendron) were developed for storage of Ca3 patterns in data files, calculation of similarity (SAB) values between strains based upon band positions and intensities, and generation of histograms and dendrograms based on SAB values for all strains or any subset of strains in large epidemiological studies. In testing the effectiveness of the system, it was found that (i) multiple isolates from different body locations of the same healthy individual could represent either the same strain or different strains, (ii) isolates from oral lesions of a husband and wife represented the same strain, (iii) strains isolated from the mouths of 10 healthy individuals on the same day and in the same geographical location were as dissimilar on average as the 46 unrelated tester strains, and (iv) strains isolated from seven immunocompromised patients hospitalized over a 2.5-month period in the same hospital were highly similar, indicating nosocomial origin. The apparent effectiveness of these fingerprinting methods and the Dendron program suggests that interlaboratory procedures for fingerprinting should be standardized and all patterns should be analyzed and stored in a common and accessible data base for broad epidemiological analysis.
Ischemic colitis in postmenopausal women taking hormone replacement therapy

Background and aim. Estrogen and progestins have established effects on the gastrointestinal tract and ischemic colitis was related in the past with certain regimens including both hormones. On this basis, we aimed to evaluate a group of postmenopausal women who presented with ischemic colitis after taking hormone replacement therapy (HRT) for the last several months. Method. Postmenopausal women taking conjugated estrogens, conjugated estrogens plus medroxyprogesterone acetate, 17β-estradiol plus norethisterone and estradiol valerate plus norgestrel are included in the present study. All patients, without a medical history of bowel problems, reported an acute crisis of colitis a few months after the beginning of the treatment. Results. Fasting, parenteral nutrition, intravenous antibiotic treatment with metronidazole and discontinuation of HRT proved successful. Antibiotics were continued after the patients' discharge from the hospital. A second-look colonoscopy, 3 to 4 months after the initial episode, was normal in all cases. Conclusion. Ischemic colitis is a rare complication of HRT that should not be ignored when HRT is prescribed.