Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti-Influenza Virus Activity of Propolis in Vitro and its Efficacy against Influenza Infection in Mice

Background: Propolis has been used worldwide as a dietary supplement to maintain and improve human health. We examined whether ethanol extracts of Brazilian propolis exhibit antiviral activity against influenza virus in vitro and in vivo. Methods: Among 13 ethanol extracts screened in a plaque reduction assay, four showed anti-influenza virus activity. The anti-influenza efficacy of the four extracts was further examined in a murine influenza virus infection model. The mice were infected intranasally with influenza virus, and the four extracts were orally administered at 10 mg/kg three times daily for seven successive days after infection. Results: In this infection model, only one extract, AF-08, was significantly effective at 10 mg/kg in reducing the body weight loss of infected mice. The doses of 2 and 10 mg/kg were also effective in prolonging the survival times of infected mice significantly, but 0.4 mg/kg was not. The anti-influenza efficacy of AF-08 at 10 mg/kg was confirmed in a dose-dependent manner in mice. AF-08 at 10 mg/kg significantly reduced virus yields in the bronchoalveolar lavage fluids of lungs in infected mice as compared with the control. The reduction of virus yields by AF-08 at 10 mg/kg significantly corresponded to those induced by oseltamivir at 1 mg/kg twice daily from day 1 to day 4 after infection. Conclusion: The Brazilian propolis AF-08 was indicated to possess anti-influenza virus activity and to ameliorate influenza symptoms in mice. AF-08 may be a possible candidate for an anti-influenza dietary supplement for humans.
Weak leakage resilient extractable hash proof system and construction for weak leakage resilient CCA-secure public-key encryption

Public-key encryption can be used in cloud systems to protect data in data sharing, identity authentication, etc. However, traditional public-key encryption does not capture the side-channel attacks. Inspired by this, the model of key-leakage attacks is formalised. However, constructing schemes in this model seems somewhat difficult and most key-leakage attacks in reality may be weak. In this paper, we consider the model of weak key-leakage attacks and focus on how to construct a weak leakage-resilient CCA-secure key encapsulation scheme. To this end, we present the new definitions of weak leakage-resilient extractable hash proofs and weak leakage-resilient partial ABO-extractable hash proofs and propose generic transformations to construct them from extractable hash proof. Then we show how to derive a weak leakage-resilient CCA-secure key encapsulation scheme based on them. We also give a concrete instantiation in a group of prime order and design an experiment to show the leakage-resilience in reality.
Application of a new Restricted Boltzmann Machine to Radar Target Recognition

When facing radar target recognition, the main problems focus on the data representation capability and the robustness to cope with noise. The merits of deep learning such as automatic setting for training and hierarchical extraction of features. Most of existing deep networks are related to Restricted Boltzmann machine (RBM), which has played an important role in deep learning techniques. The models election problem in RBM and its deep architecture is very intractable since both their learning and inference are highly time-consuming. As regular RBM has a restriction between visible units and hidden units, this restriction will cause reduction of the recognition probability when training data samples are degraded by noise. Fuzzy Restricted Boltzmann machine (FRBM) is a new RBM, in which the parameters of collection between visible units and hidden units are replaced by fuzzy number. In this paper, FRBM has been applied to moving airplane radar target data. Tested target contain three categories airplane HRRP data samples. The proposed FRBM can significantly reduce the number of free parameters and the degree of over fitting. Moreover, compared with RBM and traditional classification methods, it has showed better representation capacity and better robustness property when the training data are contaminated by noises.
Changes in quality of life and their relation to cephalometric changes in orthognathic surgery patients.

OBJECTIVE To evaluate correlations between presurgical and postsurgical changes in quality of life (QoL) and cephalometric hard and soft tissue changes in patients undergoing orthognathic surgery. MATERIALS AND METHODS The study sample consisted of 30 patients (mean age 24.3 ± 4.5 years) with Class III malocclusion undergoing orthognathic surgery for mandibular setback with a median follow-up of 8.3 ± 1.2 months. Presurgical and postsurgical cephalograms were traced and Oral Health Impact Profile (OHIP) questionnaires were completed. Each questionnaire consisted of 14 items designed to evaluate functional, physical, psychological, and social impacts. RESULTS Significant correlations between significant presurgical-to-postsurgical changes in individual items and OHIP parameters were found between labiomental angle (LA) and question 5 ("feeling self-conscious"; correlation coefficient [r] = 0.530), between LA and question 6 ("feeling tense"; r = 0.598), between nasion-pogonion and question 5 (r = 0.523), and between facial convexity and question 5 (r = -0.540). Hence, reduction of both LA and nasion-pogonion led to a significant decrease in the impact scores of items covering psychological discomfort, while reduced facial convexity led to increased impact scores. CONCLUSIONS Although the associations were moderate, changes in QoL following cephalometric modifications should be considered as a major concern when planning orthognathic surgery. Postsurgical changes to a more convex profile after mandibular setback should be emphasized before surgery to help patients become accustomed to their new appearance more easily without negatively affecting QoL.
Can genetic testing guide the therapy of cholestatic pruritus? A case of benign recurrent intrahepatic cholestasis type 2 with severe nasobiliary drainage‐refractory itch

Benign recurrent intrahepatic cholestasis (BRIC) is a peculiar familial disease caused by mutations of the genes encoding hepatocanalicular flippase for phosphatidylserine (ATP8B1; BRIC type 1) or the bile salt export pump (ABCB11; BRIC type 2). Here, we report on a patient with nasobiliary drainage‐refractory BRIC type 2 who improved under plasma separation and anion absorption therapy. We also suggest that nasobiliary drainage might be an ineffective approach in carriers of severe loss‐of‐function mutations of the bile salt export pump ABCB11. (Hepatology Communications 2018;2:152–154)
Effective Labeled Time Slots Based D2D Transmission in Cellular Downlink Spectrums

A hybrid system consisting of a cellular network and a device-to-device (D2D) network is considered in this paper where the D2D users operate in an underlay mode and reuse the spectrums with the cellular users. Most researches focus on reusing the uplink spectrums but how to share the downlink frequency bands is seldom addressed. To share the downlink spectrums and avoid the interference to the primary cellular devices, a labeled time slots based mechanism is proposed and the implementation details are described in a real cellular system. Simulation results prove that satisfying performance can be achieved by using the proposed mechanism.
A broadband 3D frequency selective rasorber by using magnetic materials

A type of broadband 3D frequency selective rasorber (FSR) was presented, which has a passband with low insertion loss and two absorption bands at both sides of the passband. By loading lumped resistors, inductors and magnetic materials, two broad absorption bands were obtained. Equivalent circuit models illustrate the physical mechanism of the proposed FSRs with high selectivity, low insertion loss at passband and broad bandwidth at absorption bands. It shows that the proposed FSR has bandwidth of 4.3∼15.8GHz with reflectivity of −10dB, which includes a bandwidth of 1.24:1 for the insertion loss less than 3dB, a bandwidth of 1.28:1 for the lower absorption band and a bandwidth of 2:1 for the upper absorption band.
Energy metabolism in human slow and fast twitch fibres during prolonged cycle exercise.

1. The effects of prolonged exercise on energy metabolism in type I and type II muscle fibres in the vastus lateralis muscle were investigated in six male subjects (20.0 +/‐ 0.5 years, mean +/‐ S.E.M.) who performed one‐legged cycling at 61% of maximum O2 consumption (VO2,max; determined with one leg) until fatigue or for a maximum of 2 h. 2. Analysis of pools of freeze‐dried fibres obtained by needle biopsy and separated into specific types by the myofibrillar ATPase histochemical procedure indicated higher (P less than 0.05) lactate concentrations in type II fibres compared to type I fibres at 15 min (43.9 +/‐ 9.7 and 51.2 +/‐ 9.8 mmol (kg dry wt)‐1) and at 60 min (18.2 +/‐ 4.7 and 25.9 +/‐ 6.5 mmol (kg dry wt)‐1). No differences existed in lactate concentration between fibre types for pre‐exercise (10.0 +/‐ 1.6 and 13.3 +/‐ 2.8 mmol (kg dry wt)‐1) or post‐exercise. 3. Glycogen degradation was most pronounced in type I fibres. By the end of exercise, glycogen concentration was 82.4 +/‐ 45 mmol glucosyl units (kg dry wt)‐1 in type I fibres and 175 +/‐ 62 mmol glucosyl units (kg dry wt)‐1 in type II fibres. 4. No significant changes in ATP and creatine phosphate (CrP) were found in either fibre type with exercise. 5. It is concluded that, at least for lactate and glycogen, fibre‐specific differences are evident in prolonged submaximal exercise. The cause of the difference probably relates both to the unique energy metabolic characteristics of each fibre type and to the manner in which they are utilized during the exercise. 6. The failure to find a reduction in ATP concentration in either fibre type during prolonged exercise in the face of a progressive increase in the number of fibres showing little or no glycogen concentration suggests that protective mechanisms exist that prevent an energy crisis. The nature of these protective mechanisms remains to be elucidated.
SeqAnt 2012: Recent Developments in Next-Generation Sequencing Annotation

The discovery of genome-wide genetic variation was central to the field of genomics [1,2]. Now, recent advances in second-generation sequencing technologies and better methods of targeted enrichment mean the detection of genome-wide patterns of genetic variation will soon be a routine operation [3,4]. Yet these advances in DNA sequencing have revealed a new bottleneck: the functional classification and interpretation of newly discovered genetic variation.
Cytosolic Gag p24 as an Index of Productive Entry of Human Immunodeficiency Virus Type 1

ABSTRACT We have investigated the cellular uptake of Gag p24 shortly after exposure of cells to human immunodeficiency virus (HIV) particles. In the absence of envelope glycoprotein on virions or of viral receptors or coreceptors at the cell surface, p24 was incorporated in intracellular vesicles but not detected in the cytosolic subcellular fraction. When appropriate envelope-receptor interactions could occur, the nonspecific vesicular uptake was still intense and cytosolic p24 represented 10 to 40% of total intracellular p24. The measurement of cytosolic p24 early after exposure to HIV type 1 is a reliable assay for investigating virus entry and early events leading to authentic cell infection.
Development and characterization of polymorphic microsatellite markers for the sweet orange (Citrus sinensis L. Osbeck)

The aims of this study were to develop simple sequence repeat markers (SSRs or microsatellite markers) in citrus and to evaluate the efficiency of these markers for characterization of sweet orange. We developed SSRs from a genomic library of 'Pera IAC' sweet orange enriched for AG/TC, GT/CA, TCA/AGT and AAC/TTG sequence repeats. We selected 279 sequences from which 171 primer pairs were designed of which 113 with the best banding patterns were selected. Characterization of sweet orange microsatellite loci revealed that AG/TC was the most abundant (69%) microsatellite class isolated, followed by GT/CA (15.9%), TCA/AGT (8%) and AAC/TTG (6.2%). The number of alleles ranged from 1 to 4, with a mean of 2 alleles per locus. Four microsatellite loci developed in this study were found to be useful for sweet orange DNA typing. The data obtained from microsatellites loci considered polymorphic will be useful as tools in the selection of zygotic and nucellar plants, identification of seedlings etc. for the cultivars Pera IAC, Lanceta, Pera GS 2000, Lamb Summer, Lima, Lima Tardia, Lima Verde, Mimo do Ceu, Valencia Folha Murcha, Valencia Folha Concha, Natal Murcha, Sanguinea and Baia Gigante.
Orally Disintegrating Selegiline in Parkinson Patients With Dopamine Agonist-Related Adverse Effects

Objective:To determine whether adding orally disintegrating selegiline (ODS) while decreasing dopamine agonist (DA) dosages would reduce DA-related adverse effects (AEs) of excessive daytime sleepiness (EDS), pedal edema, hallucinations, and impulse control disorders (ICDs) without compromising efficacy in Parkinson disease (PD) patients. Methods:This was a 12-week open-label study of 60 PD patients with motor fluctuations and DA-related AEs of EDS, pedal edema, hallucinations, and ICDs. Orally disintegrating selegiline was initiated at 1.25 mg once daily, and down titration of the DA was started with a goal of a 50% reduction by 1 week. At week 6, ODS was increased to 2.5 mg, and further reductions of the DA were allowed if the AEs were not resolved. Results:The addition of ODS allowed a reduction in the mean daily dose of pramipexole from 2.3 to 0.5 mg and immediate-release ropinirole from 11.2 to 2.9 mg. Most subjects reported a reduction or resolution of DA-related AEs; 94% with EDS (n = 50), 73% with pedal edema (n = 26), 86% with hallucinations (n = 15), and 84% with ICDs (n = 25). Mean activities of daily living and motor scores from the Unified Parkinson's Disease Rating Scale as well as quality-of-life scores were significantly improved without an increase in daily "off" time. The most common AEs, most of which resolved after titration, were worsening of PD, nausea/vomiting, dyskinesia, increased off time, body aches, insomnia, orthostatic hypotension, and increased anxiety and depression. Conclusions:In most subjects, the addition of ODS with decreasing dosages of DAs substantially reduced EDS, pedal edema, hallucinations, and ICDs without compromising efficacy.
Antibiotic Action of Solanum incanum Linnaeus

The fruits of Solanum incanum Linnaeus are extensively used in Kenya for the treatment of cutaneous mycotic infections and other pathological conditions. The therapeutic activity of the berries has been attributed to their content of solanine and related glycoalkaloids, which are saponins and cytostatic poisons. In the present study, however, a simpler more potent antimicrobial substance with a phosphorylated structure similar to the purine adenine was isolated from the berries. The crystals of this compound were effective inhibitors of the growth of gram-positive and -negative bacteria, yeasts, dermatophytes, and some pathogens of agricultural produce. High concentrations of the substance caused hemolysis of erythrocytes.
Design and Evaluation of the Nanorod Arrangement Pattern using Electro-magnetic Field Effect

In this study, for arranging the nanorod which fabricated by electro-chemical deposition (ECD) method, a nanorod arrangement simulation had been prepared on the basis of dielectrophoresis (DEP) principle. Following the simulation a nanorod arrangement device was designed and fabricated to verify the result of the simulation. After that, nanorod was arranged on the electrodes as AC voltage loading. As the result, the rate of the nanorod arrangement was 20.35 %.
Transition of the intestinal microbiota of dogs with age

Although it is established that the composition of the human intestinal microbiota changes with age, transition of the intestinal microbiota of animals with age has not been well studied. In the present study, we collected fresh fecal samples from dogs of 5 different age groups (pre-weanling, weanling, young, aged, senile) and analyzed the compositions of their intestinal microbiota with a culture-based method. The results suggested that the composition of the canine intestinal microbiota also changes with age. Among intestinal bacteria predominant in dog intestines, lactobacilli appeared to change with age. Both the number and the prevalence of lactobacilli tended to decrease when dogs became older. Bifidobacteria, on the other hand, was not predominant in the intestine of the dogs. We also identified lactobacilli at the species level based on 16S rRNA gene sequences and found that the species composition of Lactobacillus also changed with age. It was further suggested that bacteria species beneficial to host animals may differ depending on the host species.
Redressing Griselda: Restoration through Translation in the Clerk's Tale

Chaucer’s Clerk of Oxenford remarks on two separate occasions that he learned the story of Griselda from “Petrak” (IV 31, 1147), a statement corroborated by Chaucer’s subsequent close reliance on Petrarch for the body of his tale.1 Yet the looming silence of Boccaccio’s original version of this work, along with Chaucer’s history of repeatedly refusing to credit Boccaccio with anything, borrowed or not, makes the poet’s protestations here suspicious. Nevertheless, scholars have scoured the Clerk’s Tale for signs of the presence of Decameron X.10, but with little to show for their efforts: textual evidence of Boccaccio’s original story remains regarded by even the most optimistic critics as slight, and the work has largely been relegated to the status of hard analogue—albeit with a “relevance greater than any other. ”2 Most readers agree that Petrarch’s translation of Decameron X.10, Insignis obedientia et fides uxoria,3 serves as Chaucer’s primary source, while some agree with J. Burke Severs’s claim that Chaucer also relied on an anonymous French translation
Adaptive Output-Feedback Control of Feedforward Systems with Uncertain Parameters Coupled with All States

We propose an adaptive output-feedback control design technique for a class of feedforward systems with input-to-state stable (ISS) appended dynamics. The system contains uncertain functions involving all states with the assumed bounds on uncertain functions allowed to contain crossproducts of unknown parameters and unmeasured states. The ISS appended dynamics are coupled with all the system states and the input and the ISS Lyapunov inequalities also feature crossproducts of unknown parameters and unmeasured states. The proposed control design does not require any knowledge of magnitude bounds on unknown parameters.
Hiv-Infected Women in Europe: Gender-Specific Needs and Challenges

In collaboration with the Strong, HIV positive, Empowered Women (SHE) programme, an industry-funded initiative aimed at improving the quality of life of HIV-positive women, Antiviral Therapy has taken the excellent step to dedicate a Supplement Issue addressing the needs and challenges related to the care of women living in Europe. Included articles present the multiple facets of gender-specific issues and research gaps, ranging from HIV testing strategies to antiretroviral combination therapy, including long-term challenges associated with chronic HIV infection.
Fremdenfeindlichkeit verschwindet im Kontakt von Mensch zu Mensch. Zur Reichweite der Kontakthypothese

Die These von der gesellschaftlichen Determiniertheit der Fremdenfeindlichkeit wird durch vier Befunde aus der empirischen Forschung an rund 7.800 Schulerinnen der Sekundarstufe I geschwacht. 1. Der Einflus der Umgebung auf Fremdenfeindlichkeit ist deutlich schwacher als personale Kontaktfaktoren innerhalb von Schulklassen, insbesondere das Lehrerverhalten scheint deutlich einflusreicher. 2. Fremdenfeindlichkeit sinkt mit zunehmendem Auslanderanteil in Schulklassen. 3. Im Kontakt kann auch die Bedeutung der Zugehorigkeit zu sozialen Kategorien (Ethnie, Nationalitat, Religion) erheblich geschwacht werden - allerdings nur unter bestimmten Bedingungen. 4. Soziometrische Beziehungen (interpersonelle Kontaktpraferenzen in Gruppen) zeigen, das zwar die Freundschaften starker innerhalb der eigenen Ethnie gebildet werden, aber Ablehnungen sich ethnieunspezifisch verteilen. Hierfur wird das empirisch gesicherte Entstehen von Reziprozitatsnormen - die einer padagogischen Einflusnahme zuganglich sind - verantwortlich gemacht. (DIPF/Orig.)
Detection of local invariant features using contour

This study proposes a new method for the detection of local invariant features with contour. This method differs from traditional methods that use image intensity. Image contours can be extracted stably with changes in viewpoint, scale, illumination and other factors. The proposed algorithm first extracts the stable corner from the contour, then it fits the supporting region of the contour near the corner to an angle, and uses its bisector as the direction of the feature. Next, it searches the contour for the tangent point in the direction of the angle bisector. Finally, with the corner as the centre, and in combination with the tangent point and the feature direction, an elliptic invariant region is constructed. The feasibility of the algorithm was verified experimentally by comparing its repetition rate. Test images obtained from actual scenes include several types of transformations, such as rotation, scaling, affinity, illumination and noise. The results of the experiment show the feasibility of the proposed method for use in local invariant features detection.
Rates of antiretroviral resistance among HIV-infected patients with and without a history of injection drug use

Background:There exist concerns regarding the potential for elevated rates of antiretroviral resistance among HIV-infected injection drug users (IDUs) prescribed highly active antiretroviral therapy (HAART), however, no population-based study has examined if IDUs have elevated rates of antiretroviral resistance in comparison to non-IDUs. Objective:To evaluate the time to the development of antiretroviral resistance among antiretroviral-naive patients with and without a history of injection drug use. Methods:In British Columbia there is a province-wide HIV/AIDS treatment program that provides antiretrovirals free of charge. We examined all antiretroviral-naive patients initiating HAART between 1 August 1996 and 30 September 2000 and who were followed to 31 March 2002. The main outcome measure was the time to class-specific antiretroviral resistance. Cumulative antiretroviral resistance rates among IDUs and non-IDUs were evaluated using Kaplan–Meier methods and relative hazards were estimated using Cox regression. Results:Overall, 1191 antiretroviral-naive patients initiated HAART during the study period. Resistance mutations were observed in 298 (25%) subjects during the first 30 months of HAART. In comparison with non-IDUs, the risk of protease inhibitor resistance [relative hazard (RH), 0.9; 95% confidence interval (CI), 0.5–1.6] and non-nucleoside reverse transcriptase inhibitor resistance (RH, 1.5; 95% CI, 1.0–2.2) were similar among IDUs, and there were no differences in the rates of resistance to the sub-classes of nucleoside reverse transcriptase inhibitors. Conclusions:Resistance to all major classes of antiretrovirals were similar among IDUs and non-IDUs after 30 months of follow-up. These findings should help to allay fears that prescribing HAART to IDUs may result in elevated rates of resistance.