Miracle-dz/UniFAR-FTUs huggingface dataset:
Contemporary Psychoanalysis and The Legacy of the Third Reich: History, Memory, and Tradition. by Emily A

answer adequately one of the cardinal questions required of a reviewer: do the authors convincingly demonstrate their apparent intent with this book—in this case, that a self psychologically based treatment is the most effective way of working with psychotic patients? The richness of the book’s clinical examples suggest to me that much more is going on therapeutically that cannot be completely conceptualized in terms of selfobject transferences. In order to validate their thesis, we need to find out, as psychoanalytic therapists, whether we can repeat—or even come close to—the authors’ impressive accomplishments by utilizing self psychology concepts in our own work. My central questions remain: how much of their success is due to the application of self theory and other constructs (which they do utilize), and how much to the talent and tolerance of a particular therapist (such as Steinman) and to the therapeutic possibilities of the particular patient–therapist pair? This book is relatively short in its page count: 146, plus additional pages that make up the preface, introduction, prelude, and entre. Nevertheless, it is so abundant in theory and clinical data that it feels like a big book that demands close study if its precepts are to be adequately tested, even by clinicians who have experience doing psychotherapy with psychotic people. Those who would like to apply the approaches utilized by Garfield and Steinman might wish to consider consulting directly with the authors around their own patients. We then need to hear from these therapists, too, in order to get a sense of how much Garfield and Steinman’s remarkable work with such patients is usable, and whether other clinicians can achieve such positive results by applying self psychology constructs in treating their own psychotic patients. Systematic outcome research, of course, would also be welcome. HOWARD BACAL (LOS ANGELES, CA)
A geologically-sound representation for evolutionary multi-objective subsurface identification

A new representation for evolutionary subsurface identification from surface or well geological data is proposed. The idea is to represent the subsurface as the combination of, first, a geologically initial set of horizontal layers and, second, fault parameters like shape and displacements. Based on volume and bed-length preservation, a morphogenesis process then gives the structure at present time. A first implementation of this representation is tested on an artificial geological inverse problem in foothills region: the fault locations and dips are considered as two different objectives, and the e-MOEA multi-objective evolutionary algorithm is applied. The first results show the efficiency of the chosen representation.
Intérêt des lignées cellulaires de poisson en écotoxicologie pour l'étude de nouveaux biomarqueurs de génotoxicité

Un contexte reglementaire de plus en plus strict en evaluation du risque ecotoxicologique des milieux aquatiques exige de renforcer les outils d’evaluation. A ce titre, l’etude des biomarqueurs de genotoxicite doit etre privilegiee, compte tenu du role central de l’ADN dans le fonctionnement du vivant. L’exposition a des agents genotoxiques peut generer des dommages par interaction directe avec l’ADN, mais aussi indirectement, en modulant l’efficacite des mecanismes de reparation de l’ADN, ou la regulation epigenetique de l’expression des genes. Aujourd’hui, la plupart des biomarqueurs de genotoxicite visent les dommages primaires a l’ADN ou la mutagenicite mais les effets indirects sur sa fonctionnalite sont encore peu etudies. Dans ce contexte, a l’issue d’une analyse bibliographique comprenant la redaction d’une revue sur les mecanismes de reparation des dommages a l’ADN chez le poisson, ce travail visait au developpement methodologique de plusieurs biomarqueurs de genotoxicite a l’aide de trois lignees cellulaires pisciaires (RTL-W1, RTGill-W1 et PLHC-1). Pour ce faire, l’essai des cometes en conditions alcalines a ete decline sous plusieurs versions dans l’objectif d’utiliser une technique de base unique permettant la mesure complementaire de plusieurs biomarqueurs de genotoxicite : les dommages primaires a l’ADN, les activites de reparation et le niveau de methylation des cytosines du genome. Les resultats soulignent l’interet des trois lignees en evaluation de la genotoxicite 1) pour detecter in vitro de maniere sensible des atteintes primaires a l’ADN de natures variees a de faibles concentrations grâce a un essai des cometes modifie par une etape de digestion enzymatique avec une glycosylase (Fpg), 2) pour evaluer l’influence des contaminants sur l’activite de reparation par excision de bases (BER) via la mesure de la capacite d’incision d’un ADN substrat porteur de lesions de type 8-oxoGua par des extraits cellulaires (essai BERc). Le niveau de methylation des cytosines (5-meCyt) des lignees RTgill-W1et RTL-W1 a ete mesure par HPLC-MS-MS, leur valeur elevee permet d’envisager le parametre methylation comme biomarqueur potentiel. Ce volet necessitera cependant des etapes de validations ulterieures car il n’a pas ete techniquement possible de mettre au point un essai des cometes modifie pour la mesure du niveau de methylation de l’ADN. Plusieurs activites de reparation des lignees RTgill-W1 et RTL-W1 ont ete caracterisees et revelent de bonnes aptitudes de reparation de type « Base Excision Repair » (BER) et « Photo Enzymatic Repair » (PER) et une plus faible capacite au « Nucleotide Excision Repair » (NER), soit un profil proche de celui decrit in vivo et sans difference marquee entre les deux lignees. Les biomarqueurs developpes sur les lignees cellulaires de poisson au cours de ce travail ont egalement ete appliques a la mesure des effets genotoxiques d’effluents issus du lessivage de revetements routiers.
Control of energy storage interface with a bidirectional converter for photovoltaic systems

Efficient energy storage is one of the greatest concerns for renewable power generation. This paper focuses on the control of a battery management system (BMS) for photovoltaic (PV) applications with a high efficiency bidirectional converter. The proposed BMS control strategy utilizes the dc bus power and battery state of charge (SOC) for the charging and discharging of the battery with a bidirectional converter. The bidirectional converter includes fewer components and switches, has less switching losses with zero voltage switching, and has high gain buck-boost operations. A new control algorithm of charging-discharging control for the battery storage system is proposed. The complete PV system with a boost dc to dc converter controller to regulate the dc link voltage, bidirectional converter based battery charge controller, and an inverter with its associated vector mode controller is implemented in the Simulink/Simpower environment. The simulation results are presented and discussed to verify the validity of the proposed control algorithm.
Two sulfonate metabolites of physalin A in rats

Abstract 1. Physalin A is a bioactive withanolide isolated from the natural plant Physalis alkekengi var. franchetii (Solanaceae), a common traditional Chinese herbal medicine. This study aims to investigate the metabolites of physalin A in vivo. 2. Two metabolites (M1 and M2) were characterized as sulfonate metabolites in the feces obtained from rats treated with physalin A orally at a dose of 15 mg/kg/day for 3 days, by application of a UPLC-Q/TOF-MS method. Furthermore, formation of the two sulfonate metabolites was verified by chemical synthesis and NMR, including 1H NMR, 13C NMR and two-dimensional NMR. The structures of M1 and M2 were identified to be 3α-sulfo-2,25β,27-trihydrophysalin A and 3α,27-disulfo-2,25α-dihydrophysalin A, respectively. 3. In summary, this study indicated that physalin A could be biotransformed to sulfonate metabolites with strong polarity, which contributed to the elimination of physalin A. A rare metabolic pathway has been revealed in this study.
Predicción de las calificaciones de los estudiantes: la capacidad explicativa de la inteligencia general y de la motivación

Este articulo considera, por una parte, las criticas que se han elevado a la validez y a la fiabilidad de las calificaciones escolares como expresion de la evaluacion educativa y, por otro lado, los trabajos que consideran a las variables intelectuales y motivacionales de los estudiantes como predictores de los resultados de sus evaluaciones. El objetivo inicial es valorar, ahora que la Reforma Educativa se ha generalizado, en que medida la inteligencia general y la motivacion actuan como variables predictoras de las notas de diferentes areas y asignaturas. La muestra la componen 667 alumnos y alumnas del segundo ciclo de Educacion Secundaria Obligatoria y de Bachillerato. Se llevan a cabo multiples analisis de regresion multiple (por el metodo paso a paso de seleccion de variables) y el factor motivacional "Autoexigencia de rendimiento elevado', evaluado con el cuestionario P-4 de Pelechano (1 g8g), es la variable que, en general, mayor poder predictivo muestra entre todas las consideradas.
Genetic and Biochemical Characterization of Human AP Endonuclease 1 Mutants Deficient in Nucleotide Incision Repair Activity

Background Human apurinic/apyrimidinic endonuclease 1 (APE1) is a key DNA repair enzyme involved in both base excision repair (BER) and nucleotide incision repair (NIR) pathways. In the BER pathway, APE1 cleaves DNA at AP sites and 3′-blocking moieties generated by DNA glycosylases. In the NIR pathway, APE1 incises DNA 5′ to a number of oxidatively damaged bases. At present, physiological relevance of the NIR pathway is fairly well established in E. coli, but has yet to be elucidated in human cells. Methodology/Principal Finding We identified amino acid residues in the APE1 protein that affect its function in either the BER or NIR pathway. Biochemical characterization of APE1 carrying single K98A, R185A, D308A and double K98A/R185A amino acid substitutions revealed that all mutants exhibited greatly reduced NIR and 3′→5′ exonuclease activities, but were capable of performing BER functions to some extent. Expression of the APE1 mutants deficient in the NIR and exonuclease activities reduced the sensitivity of AP endonuclease-deficient E. coli xth nfo strain to an alkylating agent, methylmethanesulfonate, suggesting that our APE1 mutants are able to repair AP sites. Finally, the human NIR pathway was fully reconstituted in vitro using the purified APE1, human flap endonuclease 1, DNA polymerase β and DNA ligase I proteins, thus establishing the minimal set of proteins required for a functional NIR pathway in human cells. Conclusion/Significance Taken together, these data further substantiate the role of NIR as a distinct and separable function of APE1 that is essential for processing of potentially lethal oxidative DNA lesions.
Chest CT scan screening for lung cancer in asbestos occupational exposure: a systematic review and meta-analysis.

OBJECTIVE Lung cancer is the most frequent malignant asbestos-related pathology and remains the most fatal cancer of industrialized countries. In heavy smokers, early detection of lung cancer with chest CT scan leads to a 20% mortality reduction. However, the use of CT scan screening for early detection of lung cancer in asbestos-exposed workers requires further investigation. This study aimed to determine whether CT scan screening in asbestos-exposed workers is effective in detecting asymptomatic lung cancer using a systematic review and meta-analysis. METHODS We reviewed all cohort studies involving chest CT scan screening in former asbestos-exposed workers. The search strategy used the following keywords: "asbestos," "lung cancer," "screening," and "occupation*" or "work. " Databases were PubMed, Cochrane Library, Science Direct, and Embase. RESULTS Seven studies matched our inclusion criteria. Baseline screening detected 49 asymptomatic lung cancers among 5,074 asbestos-exposed workers. Of the 49 reported lung cancers, at least 18 were in the earliest stage (stage I), accessible to complete removal surgery. The prevalence of all lung cancers detected by CT scan screening in asbestos-exposed workers was 1.1% (95% CI, 0.6%-1.8%). CONCLUSIONS CT scan screening in asbestos-exposed workers is effective in detecting asymptomatic lung cancer. Detection of lung cancer in asbestos-exposed workers using CT scanning is at least equal to the prevalence in heavy smokers (1%; 95% CI, 0.09%-1.1%) and also shared a similar proportion of stage I diagnoses. Screening asbestos-exposed workers could reduce mortality in proportions previously observed among heavy smokers and, thus, should not be neglected, particularly for individuals combining both exposures.
Face validity and inter-rater reliability of the Danish version of the modified Yale Preoperative Anxiety Scale.

INTRODUCTION Preoperative anxiety is common in children and it is associated with an adverse post-operative outcome. The modified Yale Preoperative Anxiety Scale (m-YPAS) was developed to assess preoperative anxiety in children. The purpose of this study was to translate and adapt the m-YPAS to Danish cultural and linguistic conditions and to test its face validity and inter-rater reliability in a clinical setting. MATERIAL AND METHODS Translation was done in accordance with the WHO guidelines. Face validity and linguistic challenges were resolved in a focus group with five nurse anaesthetists. Inter-rater reliability for the subscales in the m-YPAS was determined at two different time points by using weighted kappa (κw) statistics, whereas agreement on the overall weighted scores was calculated using the intraclass correlation coefficient (ICC). The inter-rater reliability test was done by a paediatric anaesthesiologist consultant, a psychiatrist and the first author. RESULTS The Danish version of the m-YPAS was considered suitable and its face validity was satisfactory. Inter-rater reliability analysis revealed that inter-observer agreement among three independent raters was good (induction 1: κw: 0.63-0.98, ICC = 0.92; induction 2: κw: 0.72-0.96, ICC = 0.92). CONCLUSION Standardised and validated assessment tools are needed to evaluate interventions to reduce preoperative anxiety in children. A Danish version of the m-YPAS now exists, and preliminary testing has demonstrated a satisfactory face validity and inter-rater reliability. FUNDING The study was supported by grants from TrygFonden (Grant number: j.no.7-11-1292). TRIAL REGISTRATION The Danish Data Protection Agency, the Central Denmark Region, has approved the study (j.no.: 2007-58-0010).
Low-latency control structures with slack

OR-causality, or weak precedence, is a way to increase performance of asynchronous circuits in on-chip interfacing, computation process control, early evaluation in data-flow structures, error-recovery etc. The difficulties in hazard free implementation of OR-causality restricted its use to the simplest cases of merging. We advance this subject by introducing slack in the taxonomy of OR-causality, which allows latency reduction to be achieved in the context of highly pipelined operation. Petri net models and circuit structures are proposed for the bounded and "almost" unbounded merge cases. The specifics of data or control token stream merging are studied in a number of examples. Those show the applicability of the new merge constructs to a wide range of functional operators, including arithmetic, Boolean and threshold functions.
An H∞ suboptimal robust control approach for systems with uncertainties and data dropouts

This paper studies the design of control systems subject to plant uncertainties and data losses in the channel connecting the plant sensor with the controller. The controller design has two main objectives. The first one is to robustify the control law against plant uncertainties. The other one is to achieve good performance by minimising the variance of the error signal. Data losses are modelled as an independent and identically distributed sequence of Bernoulli random variables. For analysis and design, this random variable is replaced by an additive noise plus gain channel model. To cope with structural uncertainties in the model of the plant, an H∞ control technique is employed. The controller is synthesised in order to make the closed-loop system robust against structural uncertainties of the nominal model, while achieving optimal performance of the system in the presence of dropouts.
Dimethylsulfoniopropionate and Methanethiol Are Important Precursors of Methionine and Protein-Sulfur in Marine Bacterioplankton

ABSTRACT Organic sulfur compounds are present in all aquatic systems, but their use as sources of sulfur for bacteria is generally not considered important because of the high sulfate concentrations in natural waters. This study investigated whether dimethylsulfoniopropionate (DMSP), an algal osmolyte that is abundant and rapidly cycled in seawater, is used as a source of sulfur by bacterioplankton. Natural populations of bacterioplankton from subtropical and temperate marine waters rapidly incorporated 15 to 40% of the sulfur from tracer-level additions of [35S]DMSP into a macromolecule fraction. Tests with proteinase K and chloramphenicol showed that the sulfur from DMSP was incorporated into proteins, and analysis of protein hydrolysis products by high-pressure liquid chromatography showed that methionine was the major labeled amino acid produced from [35S]DMSP. Bacterial strains isolated from coastal seawater and belonging to the α-subdivision of the division Proteobacteria incorporated DMSP sulfur into protein only if they were capable of degrading DMSP to methanethiol (MeSH), whereas MeSH was rapidly incorporated into macromolecules by all tested strains and by natural bacterioplankton. These findings indicate that the demethylation/demethiolation pathway of DMSP degradation is important for sulfur assimilation and that MeSH is a key intermediate in the pathway leading to protein sulfur. Incorporation of sulfur from DMSP and MeSH by natural populations was inhibited by nanomolar levels of other reduced sulfur compounds including sulfide, methionine, homocysteine, cysteine, and cystathionine. In addition, propargylglycine and vinylglycine were potent inhibitors of incorporation of sulfur from DMSP and MeSH, suggesting involvement of the enzyme cystathionine γ-synthetase in sulfur assimilation by natural populations. Experiments with [methyl-3H]MeSH and [35S]MeSH showed that the entire methiol group of MeSH was efficiently incorporated into methionine, a reaction consistent with activity of cystathionine γ-synthetase. Field data from the Gulf of Mexico indicated that natural turnover of DMSP supplied a major fraction of the sulfur required for bacterial growth in surface waters. Our study highlights a remarkable adaptation by marine bacteria: they exploit nanomolar levels of reduced sulfur in apparent preference to sulfate, which is present at 106- to 107-fold higher concentrations.
Diseases associated with childhood obesity.

OBJECTIVE Radiologists can play an active role in children's health by increasing awareness of diseases associated with obesity. This article reviews key imaging findings in obesity-related diseases, current issues in imaging obese children, and treatment strategies. CONCLUSION There has been a well-documented pediatric obesity epidemic and a dramatic increase in clinical diseases associated with it. These serious health consequences affect nearly every organ system. Despite the increasing prevalence of obesity and the associated health hazards, pediatric obesity as a diagnosis is often overlooked by health care providers.
An Affine Arithmetic-Based Framework for Uncertain Power Flow and Optimal Power Flow Studies

This paper proposes a unified framework based on affine arithmetic for computing reliable enclosures of uncertain power flow (PF) and optimal power flow (OPF) solutions. The main idea is to formulate a generic mathematical programming problem under uncertainty by means of equivalent deterministic problems, and to identify the affine forms describing the data uncertainty by means of a signal processing technique based on principal components analysis. Compared to existing solution algorithms, this formulation presents greater flexibility, as it allows to find feasible solutions and inclusion of multiple equality and inequality constraints, and reduce the approximation errors to obtain better PF and OPF solution enclosures. Detailed numerical results are presented and discussed using a variety of realistic test systems, demonstrating the effectiveness of the proposed methodologies and comparing it to existing techniques for uncertain PF and OPF analysis.
Molecular epidemiology of rotaviruses associated with pediatric diarrhea in Bangkok, Thailand

Rotavirus diarrhea in 453 pediatric patients (29.8% of 1,518) was studied in greater Bangkok during 1985 to 1987. The disease persisted all year, increasing in incidence from August to January (30 to 50%). Polyacrylamide gel electrophoresis of rotavirus RNA from these patients and from an additional 46 patients of a 1982 to 1983 epidemic revealed 26 electropherotypes, 4 with short (S) and 22 with long (L) RNA profiles. Of the analyzed specimens, 85.5% were L forms. Only one or a few electropherotypes predominated in each epidemic, whereas others appeared sporadically at low frequencies. Shifts in the predominant electropherotypes were observed in every epidemic. Of these, 126 strains were tested for subgroup and serotype by monoclonal antibody enzyme immunoassay. Serotype 4 prevailed from 1982 to 1983, while serotype 1 was encountered more frequently than serotypes 2 and 4 from 1985 to 1987. A complete correlation was found between the electrophoretic migration of segments 10 and 11 and the serologically defined subgroup specificity. Distinct electropherotypes occurred within the same serotype, and strains with the identical electropherotype always showed the same serotype specificity. No specific electropherotype or serotype correlated with patient age. In this study, atypical rotaviruses and mixed infections with different rotaviruses were identified.
Valuation of Non-Life Liabilities from Claims Triangles

This paper provides a complete program for the valuation of aggregate non-life insurance liability cash flows based on claims triangle data. The valuation is fully consistent with the principle of valuation by considering the costs associated with a transfer of the liability to a so-called reference undertaking subject to capital requirements throughout the runoff of the liability cash flow. The valuation program includes complete details on parameter estimation, bias correction and conservative estimation of the value of the liability under partial information. The latter is based on a new approach to the estimation of mean squared error of claims reserve prediction.
THE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY

The intestinal Paneth cell (PC) population in man is estimated to be 2 x iO cells (1), while in the rat, approximately 5% of the ileal mucosa is comprised ofPC (6). The cell’s established functions include secretion of lysozyme (4) and phagocytosis of intestinal microorganisms (2, 3). Recent ultrastructural and immunocytochemical studies have further suggested that PC may be an important component of an intestinal defense system composed of antibacterial agents, immunocompetent cells, and intestinal phagocytes (7). Because the PC possesses dual functions of secretion and phagocytosis, the morphological study of each of these processes is complicated by the other. Therefore, in order to provide quantitative baseline information for future physiological studies the morphometric analysis reported here was performed on the resting (non-secreting) PC.