Miracle-dz/UniFAR-FTUs huggingface dataset:
Methodological and statistical concerns of the experimental behavioral researcher

This special issue poses anonymous questions, then provides the answers and a discussion of the issues by the expert who responded. The answers are not anonymous--partly to give credit to the experts and partly to encourage future communication and debate on whatever lingering controversies may arise. After a number of questions, the special issue concludes with a discussion by the guest editor that summarizes the answers and provides straightforward answers to questions that were not addressed by the experts.
RELATIVE POSE ESTIMATION USING IMAGE FEATURE TRIPLETS

Abstract. A fully automated reconstruction of the trajectory of image sequences using point correspondences is turning into a routine practice. However, there are cases in which point features are hardly detectable, cannot be localized in a stable distribution, and consequently lead to an insufficient pose estimation. This paper presents a triplet-wise scheme for calibrated relative pose estimation from image point and line triplets, and investigates the effectiveness of the feature integration upon the relative pose estimation. To this end, we employ an existing point matching technique and propose a method for line triplet matching in which the relative poses are resolved during the matching procedure. The line matching method aims at establishing hypotheses about potential minimal line matches that can be used for determining the parameters of relative orientation (pose estimation) of two images with respect to the reference one; then, quantifying the agreement using the estimated orientation parameters. Rather than randomly choosing the line candidates in the matching process, we generate an associated lookup table to guide the selection of potential line matches. In addition, we integrate the homologous point and line triplets into a common adjustment procedure. In order to be able to also work with image sequences the adjustment is formulated in an incremental manner. The proposed scheme is evaluated with both synthetic and real datasets, demonstrating its satisfactory performance and revealing the effectiveness of image feature integration.
Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma

Robust biomarkers for population-level hepatocellular carcinoma (HCC) surveillance are lacking. We compared serum midkine (MDK), dickkopf-1 (DKK1), osteopontin (OPN) and AFP for HCC diagnosis in 86 HCC patients matched to 86 cirrhotics, 86 with chronic liver disease (CLD) and 86 healthy controls (HC). Based on the performance of each biomarker, we assessed a separate longitudinal cohort of 28 HCC patients, at and before cancer diagnosis. Serum levels of MDK and OPN were higher in HCC patients compared to cirrhosis, CLD and HC groups. DKK1 was not different between cases and controls. More than half of HCC patients had normal AFP. In this AFP-negative HCC cohort, 59.18% (n = 29/49) had elevated MDK, applying the optimal cut-off of 0.44 ng/ml. Using AFP ≥ 20 IU/ml or MDK ≥ 0.44 ng/ml, a significantly greater number (76.7%; n = 66/86) of HCC cases were detected. The area under the receiver operating curve for MDK was superior to AFP and OPN in NASH-HCC diagnosis. In the longitudinal cohort, MDK was elevated in 15/28 (54%) of HCC patients at diagnosis, of whom 67% had elevated MDK 6 months prior. Conclusion: AFP and MDK have a complementary role in HCC detection. MDK increases the diagnostic yield in AFP-negative HCC and has greater diagnostic performance than AFP, OPN and DKK-1 in the diagnosis of NASH-HCC. Additionally, MDK has a promising role in the pre-clinical diagnosis of HCC.
Pressure increase of the electron-phonon interaction in superconducting hexagonal silicon.

Using an ab initio pseudopotential approach, the pressure dependence of the electron-phonon interaction parameter $\ensuremath{\lambda}$ and the phonon frequencies for metallic hexagonal phases of silicon is calculated. With changing pressure $\ensuremath{\lambda}$ is found to go first through a minimum and then reach its maximum value near the phase transition from simple hexagonal (sh) to hexagonal close packed (hcp). At this point the superconducting transition temperature ${T}_{c}$ is expected to be above 10 K. In the hcp phase Si is predicted to be superconducting with ${T}_{c}$ in the same range as in the sh phase.
A Procedural Logic

Much of our commonsense knowledge about the real world is concerned with the way things are done. This knowledge is often in the form of procedures or sequences of actions for achieving particular goals. In this paper, a formalism is presented for representing such knowledge based on the notion of process. A declarative semantics for the representation is given, which allows a user to state facts about the effects of doing things in the problem domain of interest. An operational semantics is also provided, which shows how this knowledge can be used to achieve given goals or to form intentions regarding their achievement. The formalism also serves as an executable program specification language suitable for constructing complex systems.
The welfare implications of costly information provision

We study information acquisition in a framework characterized by strategic complementarity or substitutability. Agents’ actions are based on costly public and private signals, the precisions of which are set by a policy maker and by private agents, respectively. The policy maker – acting as a von Stackelberg leader – takes into account that an increase in the precision of public information reduces the incentives for private information acquisition. The precisions of both the public and private information available to each agent are shown to depend crucially on the degree of strategic complementarity or substitutability. We explore the welfare and policy implications of our results in economies with beauty contests, price setting complementarities, and negative externalities entailing strategic substitutability.
On the importance of being structured: instantaneous coalescence rates and a re-evaluation of human evolution

Most species are structured and influenced by processes that either increased or reduced gene flow between populations. However, most population genetic inference methods ignore population structure and reconstruct a history characterized by population size changes under the assumption that species behave as panmictic units. This is potentially problematic since population structure can generate spurious signals of population size change. Moreover, when the model assumed for demographic inference is misspecified, genomic data will likely increase the precision of misleading if not meaningless parameters. In a context of model uncertainty (panmixia versus structure) genomic data may thus not necessarily lead to improved statistical inference. We consider two haploid genomes and develop a theory which explains why any demographic model (with or without population size changes) will necessarily be interpreted as a series of changes in population size by inference methods ignoring structure. We introduce a new parameter, the IICR (inverse instantaneous coalescence rate), and show that it is equivalent to a population size only in panmictic models, and mostly misleading for structured models. We argue that this general issue affects all population genetics methods ignoring population structure. We take the PSMC method as an example and show that it infers population size changes that never took place. We apply our approach to human genomic data and find a reduction in gene flow at the start of the Pleistocene, a major increase throughout the Middle-Pleistocene, and an abrupt disconnection preceding the emergence of modern humans.
Graph Summarization for Entity Relatedness Visualization

In modern search engines, Knowledge Graphs have become a key component for knowledge discovery. When a user searches for an entity, the existing systems usually provide a list of related entities, but they do not necessarily give explanations of how they are related. However, with the help of knowledge graphs, we can generate relatedness graphs between any pair of existing entities. Existing methods of this problem are either graph-based or list-based, but they all have some limitations when dealing with large complex relatedness graphs of two related entity. In this work, we investigate how to summarize the relatedness graphs and how to use the summarized graphs to assistant the users to retrieve target information. We also implemented our approach in an online query system and performed experiments and evaluations on it. The results show that our method produces much better result than previous work.
Cystic echinococcosis amongst small ruminants and humans in central Ethiopia

This study was conducted to determine the prevalence of cystic echinococcosis (CE) in small ruminants and humans in Addis Ababa, central Ethiopia. A cross-sectional study involving systematic random sampling was conducted to estimate the prevalence of CE in 512 small ruminants (262 sheep and 250 goats) slaughtered at Addis Ababa Abattoir Enterprise between October 2011 and March 2012. Hydatid cysts were identified macroscopically during postmortem examination and their fertility and viability were determined. CE was observed in 21 (8.02%) sheep and 17 (6.80%) goats. In sheep 13 (4.96%) of the lungs, 10 (3.81%) livers and 1 (0.381%) heart were found to be infected with hydatid cysts. Involvement of lung and liver in goats was found to be 10 (4.0%) and 8 (3.2%) respectively, with no cysts recorded in the heart. Of the total of 77 and 47 cysts encountered in sheep and goats, 33 (42.85%) and 15 (31.91%) respectively were fertile. Viability of protoscoleces from fertile cysts in sheep (29 [87.87%]) was higher than in goats (6 [40.0%]). For humans, retrospective analysis covering five years of case reports at two major hospitals in Addis Ababa between January 2008 and December 2012 showed that of the total of 25 840 patients admitted for ultrasound examination, 27 CE cases were registered, a prevalence of 0.1% and mean annual incidence rate of approximately 0.18 cases per 100 000 population. Liver was the major organ affected in humans (81.5% in affected patients) followed by spleen (11.1%) and kidney (7.4%). Logistic regression analysis showed that prevalence of CE varied significantly in relation to host age in the small ruminants (OR = 3.93, P < 0.05) as well as in humans (95% CI, R = 4.8). This epidemiological study confirms the importance of CE in small ruminants and humans in central Ethiopia, emphasising the need for integrated approaches to controlling this neglected preventable disease.
Tartrate-resistant acid phosphatase (TRAP) and the osteoclast/immune cell dichotomy

Tartrate-resistant acid phosphatase (TRAP), once considered to be just a histochemical marker of osteoclasts is now recognised to be a molecule of widespread occurrence with functions in both the skeleton and the immune system. TRAP is expressed by osteoclasts, macrophages, dendritic cells and a number of other cell types. It has a critical role in many biological processes including skeletal development, collagen synthesis and degradation, the mineralisation of bone, cytokine production by macrophages and dendritic cells, macrophage recruitment, dendritic cell maturation and a role in the development of Th1 responses. TRAP is able to degrade skeletal phosphoproteins including osteopontin (OPN), identical to the T-cell cytokine, Eta-1. In this review, we discuss the role of TRAP in bone and immune cells and suggest that TRAP may be implicated in autoimmune disorders regulated by Th1 inflammatory responses as well as certain cancers.
Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca2+ in mitochondrial dynamics

Alzheimer's disease (AD) is the most common type of age-related dementia. The disease is characterized by a progressive loss of cognitive abilities, severe neurodegeneration, synaptic loss and mitochondrial dysfunction. The Wnt signaling pathway participates in the development of the central nervous system and growing evidence indicates that Wnts also regulate the function of the adult nervous system. We report here, that indirect activation of canonical Wnt/β-catenin signaling using Bromoindirubin-30-Oxime (6-BIO), an inhibitor of glycogen synthase kinase-3β, protects hippocampal neurons from amyloid-β (Aβ) oligomers with the concomitant blockade of neuronal apoptosis. More importantly, activation with Wnt-5a, a non-canonical Wnt ligand, results in the modulation of mitochondrial dynamics, preventing the changes induced by Aβ oligomers (Aβo) in mitochondrial fission-fusion dynamics and modulates Bcl-2 increases induced by oligomers. The canonical Wnt-3a ligand neither the secreted Frizzled-Related Protein (sFRP), a Wnt scavenger, did not prevent these effects. In contrast, some of the Aβ oligomer effects were blocked by Ryanodine. We conclude that canonical Wnt/β-catenin signaling controls neuronal survival, and that non-canonical Wnt/Ca2+signaling modulates mitochondrial dysfunction. Since mitochondrial dysfunction is present in neurodegenerative diseases, the therapeutic possibilities of the activation of Wnt signaling are evident.
OSS and their Refactorings

In this paper, we focus on the net changes in attributes across versions of OSS and use net class change data (class additions and deletions) as well as refactoring data from a previous study to inform our understanding of how those three systems evolved as they did. While the majority of new attributes were added at levels 1 and 2 of the inheritance, these patterns were not consistent. The research question addresses the evolutionary relationship between classes and attributes as well as the connection between those changes and refactorings. Although some evidence of attributes following patterns conformant with class additions was found, we also identified occurrences of attributes being added unilaterally. A strong correspondence was also found between attribute addition and the refactoring data. Finally, we explore features of a fourth system with seven inheritance levels for similar characteristics.
Estimation and correction of ultrasonic wavefront distortion using pulse-echo data received in a two-dimensional aperture

Pulse-echo measurements from random scattering and from a point target have been used to quantify transmitter beam size effects and isoplanatic patch size as well as to evaluate the performance of different aberration compensation techniques. Measurements were made using a single-element transmitter with a diameter of 1/2 in. , 1 in. , or 2 in. , each focused at 3 in. A tissue-mimicking scattering phantom or a point target was used to produce echoes that were received in a two-dimensional aperture synthesized by scanning a linear array. A specimen of abdominal wall was placed in the reception path to produce aberration. B-scan images were formed with no compensation, with time-shift compensation in the receiving aperture, and with backpropagation followed by time-shift compensation. The isoplanatic patch size was estimated by compensating the focus of a test point target with the parameters estimated for an original point target position, and observing the deterioration of compensation effects with increasing distance between the test and the original point targets. The results of the measurements using different transmitter diameters quantify the improvement of time-delay estimation with the increase in wavefront coherence that accompanies decreased transmitter beam size. For seven specimens, the average isoplanatic patch size determined from a 10% increase in the -10 dB effective diameter was 16.7 mm in the azimuthal direction and 39.0 mm in the range direction. These sizes increased after backpropagation to 19.0 mm and 41.4 mm, respectively. For the 1/2 in. , 1 in. , and 2 in. diameter transmitters, the average contrast ratio improvement was 2.0 dB, 2.1 dB, and 2.8 dB, respectively, with time-shift compensation, and 2.3 dB, 2.7 dB, and 3.5 dB, respectively, with backpropagation of 20 mm followed by time-delay estimation and compensation. The investigation indicates that a tightly focused transmitter beam is necessary to create a scattered wavefront satisfactory for time-shift estimation, the isoplanatic patch is about twice as long in the range direction as in the azimuthal direction, and backpropagation followed by time-shift compensation provides better compensation of distortion than time-shift compensation alone.
An international measure of awareness and beliefs about cancer: development and testing of the ABC

Objectives To develop an internationally validated measure of cancer awareness and beliefs; the awareness and beliefs about cancer (ABC) measure. Design and setting Items modified from existing measures were assessed by a working group in six countries (Australia, Canada, Denmark, Norway, Sweden and the UK). Validation studies were completed in the UK, and cross-sectional surveys of the general population were carried out in the six participating countries. Participants Testing in UK English included cognitive interviewing for face validity (N=10), calculation of content validity indexes (six assessors), and assessment of test–retest reliability (N=97). Conceptual and cultural equivalence of modified (Canadian and Australian) and translated (Danish, Norwegian, Swedish and Canadian French) ABC versions were tested quantitatively for equivalence of meaning (≥4 assessors per country) and in bilingual cognitive interviews (three interviews per translation). Response patterns were assessed in surveys of adults aged 50+ years (N≥2000) in each country. Main outcomes Psychometric properties were evaluated through tests of validity and reliability, conceptual and cultural equivalence and systematic item analysis. Test–retest reliability used weighted-κ and intraclass correlations. Construction and validation of aggregate scores was by factor analysis for (1) beliefs about cancer outcomes, (2) beliefs about barriers to symptomatic presentation, and item summation for (3) awareness of cancer symptoms and (4) awareness of cancer risk factors. Results The English ABC had acceptable test–retest reliability and content validity. International assessments of equivalence identified a small number of items where wording needed adjustment. Survey response patterns showed that items performed well in terms of difficulty and discrimination across countries except for awareness of cancer outcomes in Australia. Aggregate scores had consistent factor structures across countries. Conclusions The ABC is a reliable and valid international measure of cancer awareness and beliefs. The methods used to validate and harmonise the ABC may serve as a methodological guide in international survey research.
Effects of high-amylose maize starch and butyrylated high-amylose maize starch on azoxymethane-induced intestinal cancer in rats

Colorectal cancer (CRC) is a major cause of death worldwide. Studies suggest that dietary fibre offers protection perhaps by increasing colonic fermentative production of butyrate. This study examined the importance of butyrate by investigating the effects of resistant starch (RS) and butyrylated-RS on azoxymethane (AOM)-induced CRC in rats. Four groups (n = 30 per group) of Sprague–Dawley rats were fed AIN-93G-based diets containing a standard low-RS maize starch (LAMS), LAMS + 3% tributyrin (LAMST), 10% high-amylose maize starch (HAMS) and 10% butyrylated HAMS (HAMSB) for 4 weeks. Rats were injected once weekly for 2 weeks with 15 mg/kg AOM, maintained on diets for 25 weeks and then killed. Butyrate concentrations in large bowel digesta were higher in rats fed HAMSB than other groups (P < 0.001); levels were similar in HAMS, LAMS and LAMST groups. The proportion of rats developing tumours were lower in HAMS and HAMSB than LAMS (P < 0.05), and the number of tumours per rat were lower in HAMSB than LAMS (P < 0.05). Caecal digesta butyrate pools and concentrations were negatively correlated with tumour size (P < 0.05). Hepatic portal plasma butyrate concentrations were higher (P < 0.001) in the HAMSB compared with other groups and negatively correlated with tumour number per rat (P < 0.009) and total tumour size for each rat (P = 0.05). HAMSB results in higher luminal butyrate than RS alone or tributyrin. This is associated with reduced tumour incidence, number and size in this rat model of CRC supporting the important protective role of butyrate. Interventional strategies designed to maximize luminal butyrate may be of protective benefit in humans.
Algorithm adaptive video deinterlacing using self-validation framework

Deinterlacing is well known as an ill-posed problem of video restoration. In this paper, a self-validation framework is proposed to solve the problem. First, various algorithms with different assumptions will be performed to generate candidate results. Then, a method called double interpolation is applied to test the consistency of each algorithm. Finally, the value of each missing pixel will be chosen among the results of those algorithms according to their performances in the previous test. By doing so, each situation can be handled by the most suitable algorithm and the overall result can be better than any of them. Experimental results demonstrate the validity of the proposed framework in both subjective and objective assessments.
Five roles for using theory and evidence in the design and testing of behavior change interventions.

OBJECTIVE The prevailing wisdom in the field of health-related behavior change is that well-designed and effective interventions are guided by theory. METHODS Using the framework of intervention mapping, we describe and provide examples of how investigators can effectively select and use theory to design, test, and report interventions. RESULTS We propose five roles for theory and evidence about theories: a) identification of behavior and determinants of behavior related to a specified health problem (i.e., the logic model of the problem); b) explication of a causal model that includes theoretical constructs for producing change in the behavior of interest (i.e., the logic model of change); c) selection of intervention methods and delivery of practical applications to achieve changes in health behavior; d) evaluation of the resulting intervention including theoretical mediating variables; and e) reporting of the active ingredients of the intervention together with the evaluation results. CONCLUSIONS In problem-driven applied behavioral or social science, researchers use one or multiple theories, empiric evidence, and new research, both to assess a problem and to solve or prevent a problem. Furthermore, the theories for description of the problem may differ from the theories for its solution. In an applied approach, the main focus is on solving problems regarding health behavior change and improvement of health outcomes, and the criteria for success are formulated in terms of the problem rather than the theory. Resulting contributions to theory development may be quite useful, but they are peripheral to the problem-solving process.