Miracle-dz/UniFAR-FTUs huggingface dataset:
From Guided Surgery to Final Prosthesis with a Fully Digital Procedure: A Prospective Clinical Study on 15 Partially Edentulous Patients

Scope. To demonstrate guided implant placement and the application of fixed, implant-supported prosthetic restorations with a fully digital workflow. Methods. Over a 2-year period, all patients with partial edentulism of the posterior maxilla, in need of fixed implant-supported prostheses, were considered for inclusion in this study. The protocol required intraoral scanning and cone beam computed tomography (CBCT), the superimposition of dental-gingival information on bone anatomy, surgical planning, 3D-printed teeth-supported surgical templates, and modelling and milling of polymethylmethacrylate (PMMA) temporaries for immediate loading. After 3 months, final optical impression was taken and milled zirconia frameworks and 3D-printed models were fabricated. The frameworks were veneered with ceramic and delivered to the patients. Results. Fifteen patients were selected for this study. The surgical templates were stable. Thirty implants were placed (BTK Safe®, BTK, Vicenza, Italy) and immediately loaded with PMMA temporaries. After 3 months, the temporaries were replaced by the final restorations in zirconia-ceramic, fabricated with a fully digital process. At 6 months, none of the patients reported any biological or functional problems with the implant-supported prostheses. Conclusions. The present procedure for fully digital planning of implants and short-span fixed implant-supported restorations has been shown to be reliable. Further studies are needed to validate these results.
Dislocation à gauche et organisation interactionnelle

Les constructions du type Jean il est parti ou ma mère je lui ai tout dit ont abondamment été étudiées dans la littérature. On les appelle communément des dislocations à gauche. Les contraintes grammaticales régissant l’élément détaché et sa reprise ont fait l’objet d’études syntaxiques, alors que les fonctions discursives de la dislocation à gauche ont été analysées au niveau de la gestion des topics par des approches plus fonctionnalistes et discursives. A quelques exceptions près, cependant, les fonctions interactives de cette construction restent largement inexplorées.
Code Hunt : Context-Driven Interactive Gaming for Learning Programming and Software Engineering

Code Hunt is a web-based serious gaming platform for players to solve coding duels, a type of puzzle based on programming and software engineering. In Code Hunt, a player iteratively modifies code to match the functional behavior of a secret code segment. The functional behavior is defined based on unit test cases shown as input-output pairs. To guide players to modify the code segment, Code Hunt provides feedback based on test generation through the Pex engine. In Code Hunt, the way of writing code is very different from the way in traditional software development since there are no known requirements (either informally/formally documented or existing in developers’ mind); the game aspect in Code Hunt is essentially re-engineering from sample expected behaviors observed from generated test cases. Various types of context exist in Code Hunt including the duel and the test cases, as well as the player’s history and any hints that are given. In this position paper, we discuss how such context assists the players to solve coding duels while offering the players learning and fun experiences.
Understanding the AS-level Path Disjointness Provided by Multi-homing

Many recent studies have shown that end-to-end path selection can increase availability using mechanisms based on overlay networks or end-host and edge multi-homing. In this paper, we address several unanswered questions about the path diversity that these mechanisms take advantage of: regardless of the path selection techniques used, where in the network is it necessary to provide path choice in order to achieve the best gains in availability, and why is this the case? We present results of measurement simulations on inferred autonomous system (AS) topologies to discover the AS-level path disjointness properties of three multipath construction mechanisms. We find that a mechanism that selects both the egress edge leaving a source and the ingress edge entering the destination can often obtain as many disjoint paths as an optimal source routing mechanism. In contrast, choosing just the egress edge tends to favor paths that enter the same ingress edge at the destination, resulting in diminished failure resilience. These results are consistent across several different inferred AS topologies, and agree with the results observed using traceroute data between a subset of the Internet ASes.
Multi-dimensional cluster misclassification test for pathway differential analysis of diabetes

Gene pathway can be defined as a group of genes that interact with each other to perform some biological processes. Along with the efforts to identify the individual genes that play vital roles in a particular disease, there is a growing interest in identifying the roles of gene pathways in such diseases. This paper proposes an innovative method which measures the significance of the gene pathways in a particular disease using the concept of fuzzy set theory. Experiments have been conducted on published diabetes gene expression dataset together with a list of predefined pathways from KEGG. Results on the real world diabetes dataset identified OXPHOS pathway involved in oxidative phosphorylation in mitochondria and other mitochondrial related pathways to be deregulated in diabetes patients. Our results support the previously supported notion that mitochondrial dysfunction is an important event in insulin resistance and type-2 diabetes.
An intelligent joystick for biped control

We present the concept of an "intelligent" joystick, an architecture which provides simple and intuitive high-level directional control of a legged robot while adjusting the actual foot placements autonomously to avoid stepping in undesirable places. The general concept can be likened to riding a horse: high-level commands are provided, while the "intelligence" of the underlying system selects proper foot placements with respect to the shape and properties of the underlying terrain and overall balance considerations. We demonstrate a prototype system used for realtime control of the humanoid robot HRP-2
Vortex Models and Boundary Layer Instability

Random vortex methods are applied to the analysis of boundary layer instability in two and three space dimensions. A thorough discussion of boundary conditions is given. In two dimensions, the results are in good agreement with known facts. In three dimensions, a new version of the method is introduced, in which the computational elements are vortex segments. The numerical results afford new insight into the effects of the third dimension on the stability of a boundary layer over a flat plate.
The Multi-allelic Genetic Architecture of a Variance-Heterogeneity Locus for Molybdenum Concentration in Leaves Acts as a Source of Unexplained Additive Genetic Variance

Genome-wide association (GWA) analyses have generally been used to detect individual loci contributing to the phenotypic diversity in a population by the effects of these loci on the trait mean. More rarely, loci have also been detected based on variance differences between genotypes. Several hypotheses have been proposed to explain the possible genetic mechanisms leading to such variance signals. However, little is known about what causes these signals, or whether this genetic variance-heterogeneity reflects mechanisms of importance in natural populations. Previously, we identified a variance-heterogeneity GWA (vGWA) signal for leaf molybdenum concentrations in Arabidopsis thaliana. Here, fine-mapping of this association reveals that the vGWA emerges from the effects of three independent genetic polymorphisms that all are in strong LD with the markers displaying the genetic variance-heterogeneity. By revealing the genetic architecture underlying this vGWA signal, we uncovered the molecular source of a significant amount of hidden additive genetic variation or “missing heritability”. Two of the three polymorphisms underlying the genetic variance-heterogeneity are promoter variants for Molybdate transporter 1 (MOT1), and the third a variant located ~25 kb downstream of this gene. A fourth independent association was also detected ~600 kb upstream of MOT1. Use of a T-DNA knockout allele highlights Copper Transporter 6; COPT6 (AT2G26975) as a strong candidate gene for this association. Our results show that an extended LD across a complex locus including multiple functional alleles can lead to a variance-heterogeneity between genotypes in natural populations. Further, they provide novel insights into the genetic regulation of ion homeostasis in A. thaliana, and empirically confirm that variance-heterogeneity based GWA methods are a valuable tool to detect novel associations of biological importance in natural populations.
A Review on Psychological Safety: Concepts, measurements, antecedents and Consequences variables

As an important indicator of employees' psychological contract and organizational trust, psychological safety is a kind of safety awareness based on the psychological climate of certain events in organization, current scholars generally divided it into three levels: individual, group, organizational psychological safety. Its influencing factors can be divided into individual factors, interpersonal factors, leadership features and organizational context four aspects;its main outcome variables conclude the knowledge sharing, voice, innovation, job involvement and job performance. Finally, the study points out the shortcomings of existing research and future research directions.
Histone macroH 2 A 1 is concentrated in the inactive X chromosome of female preimplantation mouse embryos

X inactivation involves several changes in the structure or properties of the inactive X chromosome that are believed to play a role in the initiation and/or maintenance of transcriptional silencing (Heard et al., 1997). These include hypermethylation of CpG islands, hypoacetylation of core histones, asynchronous replication, and the accumulation of a large noncoding nuclear RNA from a gene called Xist. Xist RNA coats the inactive X chromosome in cis and is generally thought to be directly involved in the inactivation process, though how it mediates transcriptional silencing is unknown. We recently showed that the inactive X chromosome in adult female mammals is also characterized by a high concentration of the core histone macroH2A1.2, and can be distinguished in interphase nuclei as a large macroH2A-dense domain called a macrochromatin body (MCB) (Costanzi and Pehrson, 1998). MacroH2A1.2 is one of the three known macroH2A subtypes. Two subtypes, macroH2A1.1 and 1.2, are produced by alternate splicing of the macroH2A1gene (Pehrson et al., 1997; Rasmussen et al., 1999). The third subtype, macroH2A2.2, is produced from a separate gene (C. Costanzi and J. R. Pehrson, unpublished results). All three subtypes have a similar structure, consisting of an amino-terminal domain that closely resembles a full-length histone H2A followed by a large nonhistone domain that comprises 57% of the protein (Fig. 1A). The H2A domain appears to replace conventional H2A in a subset of nucleosomes and it was estimated that one in 30 nucleosomes in rat liver would contain macroH2A, assuming one macroH2A per nucleosome (Pehrson and Fried, 1992). The majority of the nonhistone region appears to have evolved from a gene of unknown function that originated prior to the appearance of eukaryotes (Pehrson and Fuji, 1998). On the basis of the homology of the nonhistone region to proteins involved in the replication of viral RNA, it was hypothesized that the nonhistone region may bind RNA and that the ocalization of macroH2A1 to the inactive X chromosome might be mediated by an interaction between the nonhistone region and Xist RNA (Pehrson and Fuji, 1998). A connection between Xist and macroH2A1 has been established in a mouse fibroblast model, in which deletion of part of the Xist locus from the inactive X chromosome leads to the loss of macroH2A1 association (Csankovszki et al., 1999). Two experimental systems have been used to examine the early events of X inactivation. One system uses female mouse embryonic stem (XX-ES) cells or embryonal carcinoma cells in vitro (Martin et al., 1978; Rastan and Robertson, 1985). In culture XX-ES cells undergo random X chromosome 2283 Development 127, 2283-2289 (2000) Printed in Great Britain © The Company of Biologists Limited 2000 DEV4325
Probabilistic Scene Modeling for Situated Computer Vision

Verbal statements and vision are a rich source of informa- tion in a human-machine interaction scenario. For this reason Situated Computer Vision aims to include knowledge about the communicative situation in which it takes place. This paper presents three approaches how to achieve scene models of such scenarios combining dierent modal- ities. Seeing (planar) scenes as configurations of parts leads to a proba- bilistic modeling with Bayes' nets relating spoken utterances with results of an object recognition step. In the second approach parallel datasets form the basis for analyzing the statistical dependencies between them through learning a statistical translation model which maps between these datasets (here: words in a text and boundary fragments extracted in 2D images). The third approach deals with complex indoor scenes from which 3D data is acquired. Planar structures in the 3D points and statis- tics extracted on these planar patches describe the coarse spatial layouts of dierent indoor room types in such a way that a holistic classification scheme can be provided.
Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion

Dynamin-related GTPase proteins (DRPs) are main players in membrane remodelling. Conserved DRPs called mitofusins (Mfn1/Mfn2/Fzo1) mediate the fusion of mitochondrial outer membranes (OM). OM fusion depends on self-assembly and GTPase activity of mitofusins as well as on two other proteins, Ugo1 and Mdm30. Here, we define distinct steps of the OM fusion cycle using in vitro and in vivo approaches. We demonstrate that yeast Fzo1 assembles into homo-dimers, depending on Ugo1 and on GTP binding to Fzo1. Fzo1 homo-dimers further associate upon formation of mitochondrial contacts, allowing membrane tethering. Subsequent GTP hydrolysis is required for Fzo1 ubiquitylation by the F-box protein Mdm30. Finally, Mdm30-dependent degradation of Fzo1 completes Fzo1 function in OM fusion. Our results thus unravel functions of Ugo1 and Mdm30 at distinct steps during OM fusion and suggest that protein clearance confers a non-cycling mechanism to mitofusins, which is distinct from other cellular membrane fusion events.
Drug treatment of hyperlipidemia in women.

CONTEXT Several clinical trials have evaluated the effects of lipid-lowering medications on coronary heart disease (CHD). Many of the trials have not included enough women to allow sex-specific analyses or have not reported results in women separately. OBJECTIVES To assess and synthesize the evidence regarding drug treatment of hyperlipidemia for the prevention of CHD events in women and to conduct a meta-analysis of the effect of drug treatment on mortality. DATA SOURCES We searched MEDLINE, the Cochrane Database, and the Database of Abstracts of Reviews of Effectiveness for articles published from 1966 through December 2003. We reviewed reference lists of articles and consulted content experts. STUDY SELECTION AND DATA EXTRACTION Studies of outpatients that had a treatment duration of at least 1 year, assessed the impact of lipid lowering on clinical outcomes, and reported results by sex were included. Outcomes evaluated were total mortality, CHD mortality, nonfatal myocardial infarction, revascularization, and total CHD events. Summary estimates of the relative risks (RRs) with therapy were calculated using a random-effects model for patients with and without a previous history of cardiovascular disease. DATA SYNTHESIS Thirteen studies were included. Six trials included a total of 11 435 women without cardiovascular disease and assessed the effects of lipid-lowering medications. Lipid lowering did not reduce total mortality (RR, 0.95; 95% confidence interval [CI], 0.62-1.46), CHD mortality (RR, 1.07; 95% CI, 0.47-2.40), nonfatal myocardial infarction (RR, 0.61; 95% CI, 0.22-1.68), revascularization (RR, 0.87; 95% CI, 0.33-2.31), or CHD events (RR, 0.87; 95% CI, 0.69-1.09). However, some analyses were limited by too few CHD events in the available trials. Eight trials included 8272 women with cardiovascular disease and assessed the effects of lipid-lowering medications. Lipid lowering did not reduce total mortality in women with cardiovascular disease (RR, 1.00; 95% CI, 0.77-1.29). However, lipid lowering reduced CHD mortality (RR, 0.74; 95% CI, 0.55-1.00), nonfatal myocardial infarction (RR, 0.71; 95% CI, 0.58-0.87), revascularization (RR, 0.70; 95% CI, 0.55-0.89), and total CHD events (RR, 0.80; CI, 0.71-0.91). CONCLUSIONS For women without cardiovascular disease, lipid lowering does not affect total or CHD mortality. Lipid lowering may reduce CHD events, but current evidence is insufficient to determine this conclusively. For women with known cardiovascular disease, treatment of hyperlipidemia is effective in reducing CHD events, CHD mortality, nonfatal myocardial infarction, and revascularization, but it does not affect total mortality.
Poly(A) RNA‐binding proteins and polyadenosine RNA: new members and novel functions

Poly(A) RNA‐binding proteins (Pabs) bind with high affinity and specificity to polyadenosine RNA. Textbook models show a nuclear Pab, PABPN1, and a cytoplasmic Pab, PABPC, where the nuclear PABPN1 modulates poly(A) tail length and the cytoplasmic PABPC stabilizes poly(A) RNA in the cytoplasm and also enhances translation. While these conventional roles are critically important, the Pab family has expanded recently both in number and in function. A number of novel roles have emerged for both PAPBPN1 and PABPC that contribute to the fine‐tuning of gene expression. Furthermore, as the characterization of the nucleic acid binding properties of RNA‐binding proteins advances, additional proteins that show high affinity and specificity for polyadenosine RNA are being discovered. With this expansion of the Pab family comes a concomitant increase in the potential for Pabs to modulate gene expression. Further complication comes from an expansion of the potential binding sites for Pab proteins as revealed by an analysis of templated polyadenosine stretches present within the transcriptome. Thus, Pabs could influence mRNA fate and function not only by binding to the nontemplated poly(A) tail but also to internal stretches of adenosine. Understanding the diverse functions of Pab proteins is not only critical to understand how gene expression is regulated but also to understand the molecular basis for tissue‐specific diseases that occur when Pab proteins are altered. Here we describe both conventional and recently emerged functions for PABPN1 and PABPC and then introduce and discuss three new Pab family members, ZC3H14, hnRNP‐Q1, and LARP4. WIREs RNA 2014, 5:601–622. doi: 10.1002/wrna.1233
Architecture of the Atlas chip-multiprocessor: dynamically parallelizing irregular applications

An important research direction for future microprocessors is the single-chip multiprocessor. The drawbacks of this approach are that many important applications cannot be automatically parallelized and that performance suffers with "dusty-deck" binaries. This paper details a single-chip multiprocessor that engages a combination of aggressive speculation techniques to enable the dynamic parallelization of irregular, sequential binaries. Thread speculation (multiscalar execution) and data value prediction are combined to enable the processor to execute dependent threads in parallel. The architecture performs a novel form of dynamic thread partitioning called MEM-slicing, and includes an extremely aggressive correlated value predictor. Several new microarchitectural structures to manage inter-thread dependencies are described. Simulations show that sequential programs are amenable to this form of execution. Over SPECint95, an average speedup of 3.4 is achieved on 8 processors due entirely to the exploitation of thread level parallelism.
Two novel related yeast nucleoporins Nup170p and Nup157p: complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p

We have taken a combined genetic and biochemical approach to identify major constituents of the yeast nuclear pore complex (NPC). A synthetic lethal screen was used to identify proteins which interact genetically with the major pore-membrane protein Pom152p. In parallel, polypeptides present in similar amounts to Pom152p in a highly enriched preparation of yeast NPCs have been characterized by direct microsequencing. These approaches have led to the identification of two novel and major nucleoporins, Nup170p and Nup157p. Both Nup170p and Nup157p are similar to each other and to an abundant mammalian nucleoporin, Nup155p (Radu, A., G. Blobel, and R. W. Wozniak. 1993. J. Cell Biol. 121: 1-9) and interestingly, nup170 mutants can be complemented with mammalian NUP155. In addition, the synthetic lethal screen identified genetic interactions between Pom152p and two other major nucleoporins, Nup188p (Nehrbass, U., S. Maguire, M. Rout, G. Blobel, and R. W. Wozniak, manuscript submitted for publication), and Nic96p (Grandi, P., V. Doye, and E. C. Hurt. 1993. EMBO J. 12: 3061-71). We have determined that together, Nup170p, Nup157p, Pom152p, Nup188p, and Nic96p comprise greater than one-fifth of the mass of the isolated yeast NPC. Examination of the genetic interactions between these proteins indicate that while deletion of either POM152, NUP170, or NUP188 alone is not lethal, pairwise combinations are. Deletion of NUP157 is also not lethal. However, nup157 null mutants, while lethal in combination with nup170 and nup188 null alleles, are not synthetically lethal with pom152 null alleles. We suggest that Nup170p and Nup157p may be part of a morphologically symmetrical but functionally distinct substructure of the yeast NPC, e.g., the nucleoplasmic and cytoplasmic rings. Finally, we observed morphological abnormalities in the nuclear envelope as a function of alterations in the expression levels of NUP170 suggesting a specific stoichiometric relationship between NPC components is required for the maintenance of normal nuclear structure.
Use of cell morphology as an early bio-sensor for viral infection

This paper reports a correlation between cellular morphology and the ability of adapting Vesicular stomatitis virus (VSV) infection. A time-lapse approach was employed to track the individual difference between homologous cells in adopting viral infection. Our single-cell analysis indicates that upon viral infection, mature cells that are in spindle shape are less likely to be infected after 24 hour infection. On the other hand, cells undergoing proliferation, which are in rounder shape, tend to adopt much higher viral infection within the same amount of time. This fact suggests cellular morphology may to be an early bio-sensor for viral infection. The findings in this paper could potentially be applied to other viral infection models.