Miracle-dz/UniFAR-FTUs huggingface dataset:
Stability-indicating UV-spectrophotometric assay of chloroquine phosphate in pharmaceuticals

Chloroquine phosphate (CQP) is a 4-aminoquinolein antimalarial drug. One spectrophotometric method which is cost-effective and rapid was described for the determination of CQP in bulk drug and dosage forms. This method is based on the measurement of the absorbance of CQP solution in 0.1 M HCl at 342 nm. Beer’s law was obe yed over the concentration range, 2.5-25 μg mL-1 (r=0.9998) with limits of detection (LOD)and quantification (LOQ) values of 0.39 and 1.18 μg mL-1, respectively. The apparent molar absorptivity was calculated to be 8.88×103L mol-1cm-1and the Sandell sensitivity was 0.0401 μg cm-2. Intraday and inter-day accuracy expressed as percent relative error was better than 1.5% and the corresponding precision reported as percent relative standard deviation (%RSD) was < 2%. Method, when applied to commercial tablets, yielded % found values in the range, 98.24 –100.6% with an RSD of < 1.5%. Accuracy of the method was confirmed by recovery study viastandard-addition procedure. The method was validated for selectivity, robustness and ruggedness also. The method was evaluated for its stability-indicating ability by forced degradation study. As a part of this, the drug was subjected to acid-, base-, peroxide-, heat-and light-induced stress conditions before recording the spectrum; and the drug was found undergo significant degradation under base hydrolysis and insignificant degradation in oxidative stress conditions, and remained stable to other conditions.
IANA Registration for an Enumservice Containing Public Switched Telephone Network (PSTN) Signaling Information

This document registers the Enumservice type "pstn" and subtype "tel" using the URI scheme 'tel', as well as the subtype "sip" using the URI scheme 'sip' as per the IANA registration process defined in the ENUM specification, RFC 3761. This Enumservice is used to facilitate the routing of telephone calls in those countries where number portability exists. [STANDARDS-TRACK]
Later stages of development of the periotic duct and its adjacent area in the human fetus

The later stages of development (16–40 weeks in utero) of the periotic duct and its adjacent areas in the human fetus indicate that the critical stages of development occur in four specific time related stages over a six‐week period (20–26 weeks). First, the petrous apex ossifies to separate the inferior cochlear vein into the canal of Cotugno and forms the medial wall of the cochlear aqueduct (22 weeks); second, the canalicular otic capsule fuses with the cochlear otic capsule to obliterate Hyrtl fissure and forms the lateral wall of the cochlear aqueduct (24 weeks); third, progressive bone deposition to the medial surface of the membranous labyrinth and cochlea at the petrous apex elongates the periotic duct and cochlear aqueduct (32 weeks in utero); and fourth, active arachnoid tissue ingrowth into the periotic duct occurs at 20–24 weeks and 34–40 weeks in utero. The terminal event is widening of the CNS opening of the periotic duct at 32 weeks in utero.
Grids challenged by a Web 2.0 and multicore sandwich

We discuss the application of Web 2.0 to support scientific research (e‐Science) and related ‘e‐more or less anything’ applications. Web 2.0 offers interesting technical approaches (protocols, message formats, and programming tools) to build core e‐infrastructure (cyberinfrastructure) as well as many interesting services (Facebook, YouTube, Amazon S3/EC2, and Google maps) that can add value to e‐infrastructure projects. We discuss why some of the original Grid goals of linking the world's computer systems may not be so relevant today and that interoperability is needed at the data and not always at the infrastructure level. Web 2.0 may also support Parallel Programming 2.0—a better parallel computing software environment motivated by the need to run commodity applications on multicore chips. A ‘Grid on the chip’ will be a common use of future chips with tens or hundreds of cores. Copyright © 2008 John Wiley & Sons, Ltd.
Coenzyme Q 10 supplementation reduces oxidative stress and increase antioxidant enzyme activity in patients with coronary artery disease

Objective: The purpose of this studywas to investigate the effect of coenzymeQ10 supplementation on oxidative stress and antioxidant enzyme activity in patients with coronary artery disease (CAD). Methods: This was an intervention study. Patients who were identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery or receiving percutaneous transluminal coronary angioplasty (n 1⁄4 51) were randomly assigned to the placebo group (n 1⁄4 14) or one of the two coenzyme Q10-supplemented groups (60 mg/d, n 1⁄4 19 [Q10-60 group]; 150 mg/d, n 1⁄4 18 [Q10-150 group]). Intervention was administered for 12 wk. Patients’ blood samples were analyzed every 4 wk for plasma coenzyme Q10 concentrations, malondialdehyde (MDA), and antioxidant enzyme (catalase [CAT], superoxide dismutase [SOD], glutathione peroxidase) activity. Results: Forty-three subjects with CAD completed intervention study. Plasma coenzyme Q10 concentration increased significantly after coenzyme the Q10-150 intervention (P < 0.01). The MDA levels were significantly lower than baseline in the Q10-150 group at week 4 (P 1⁄4 0.03). The Q10-150 group had significantly lower MDA levels than the placebo group at week 8 (P 1⁄4 0.03). With respect to antioxidant enzyme activity, subjects in the Q10-150 group had significantly higher CAT (P 1⁄4 0.03) and SOD (P 1⁄4 0.03) activity than the placebo group at week 12. The plasma coenzyme Q10 concentration was significantly correlated with MDA levels (r 1⁄4 0.35, P 1⁄4 0.02) and CAT (r 1⁄4 0.43, P 1⁄4 0.01) and SOD activity (r 1⁄4 0.39, P 1⁄4 0.01). The ratio of plasma coenzyme Q10 to total cholesterol was significantly correlated with SOD activity (r 1⁄4 0.39, P 1⁄4 0.02). The ratio of plasma coenzyme Q10 to low-density lipoprotein was significantly correlated with CAT (r 1⁄4 0.35, P 1⁄4 0.04) and SOD (r 1⁄4 0.45, P 1⁄4 0.01) activity. However, there was no relation between coenzyme Q10 concentration and glutathione peroxidase activity. Conclusion: Coenzyme Q10 supplements at a dose of 150 mg can decrease oxidative stress and increase antioxidant enzyme activity in patients with CAD. A higher dose of coenzyme Q10 supplements (>150 mg/d) might promote rapid and sustainable antioxidation in patients with CAD. 2011 Elsevier Inc. All rights reserved.
Biodegradable Hybrid Stomatocyte Nanomotors for Drug Delivery

We report the self-assembly of a biodegradable platinum nanoparticle-loaded stomatocyte nanomotor containing both PEG-b-PCL and PEG-b-PS as a potential candidate for anticancer drug delivery. Well-defined stomatocyte structures could be formed even after incorporation of 50% PEG-b-PCL polymer. Demixing of the two polymers was expected at high percentage of semicrystalline poly(ε-caprolactone) (PCL), resulting in PCL domain formation onto the membrane due to different properties of two polymers. The biodegradable motor system was further shown to move directionally with speeds up to 39 μm/s by converting chemical fuel, hydrogen peroxide, into mechanical motion as well as rapidly delivering the drug to the targeted cancer cell. Uptake by cancer cells and fast doxorubicin drug release was demonstrated during the degradation of the motor system. Such biodegradable nanomotors provide a convenient and efficient platform for the delivery and controlled release of therapeutic drugs.
Wideband matching of handset antenna ports at noncontiguous frequency bands

Due to the mutual coupling between the different excited ports, designing multiple wideband matching circuits for handset antennas is not straightforward. This paper presents design principles for wideband matching circuits of two-ports and analyzes their significance in the case of multiple noncontiguous frequency bands. The proposed optimization procedure helps to design matching circuits, which may enlarge passbands, improve isolation between antenna elements, and most important, improve efficiency in the antenna design. General principles have been illustrated with examples, and also measurement results are given.
Plating versus intramedullary fixation for acute displaced mid-shaft clavicle fractures : a meta-analysis

Background: Surgical treatment of acute displaced mid-shaft fractures of the clavicular remains challenging. In this meta-analysis, we pooled studies to compare plating with intramedullary fixation for this injury. Methods: The electronic databases MEDLINE, EMABSE, BIOSIS and Google scholar were searched. RCTs and cohort studies evaluating plating versus intramedullary fixation for displaced mid-shaft clavicle fracture were collected. The quality of the study was assessed, and meta-analyses were performed with the Cochrane Collaboration’s REVMAN 5.0 software. Results: Three RCTs and eleven cohort studies involving 934 patients were included. There were 421 patients treated with intramedullary fixation and 513 cases for plating. Functional outcomes, rate of bone union, infection and implant failure were compared and no significant difference was found. Intramedullary fixation was associated with a shorter time to bone union (MD -0.60 weeks, 95% CI -1.11 to -0.10) and for surgery (MD -21.29 minutes; 95% CI -27.93 to -14.65). Conclusion: Both plating and intramedullary fixation techniques are equally effective for the surgical treatment of acute displaced mid-shaft clavicle fractures and the intramedullary fixation technique is quicker with a shorter operative time and faster to bone union. It can be regard as an attractive alternative to plating. In the future, high quality and well designed RCTs are required to support these findings.
Postantibiotic Effects of Garenoxacin (BMS-284756) against 12 Gram-Positive or -Negative Organisms

ABSTRACT Conventional in vitro methods were used to determine the postantibiotic effects (PAEs), sub-MIC effects (SMEs), and postantibiotic sub-MIC effects (PA-SMEs) of garenoxacin for a range of organisms. The mean PAEs of garenoxacin for pneumococci, staphylococci, and enterococci were 0.3 to 2.2 h. For Escherichia coli and Pseudomonas aeruginosa, the PAEs were 0.9 to 1.6 h. The mean PA-SMEs (0.4 times the MIC) for pneumococci, staphylococci, and enterococci were 3.0 to >10 h, 1.8 to >10.7 h, and 5.8 h, respectively, while those for E. coli and P. aeruginosa were 7.6 and 4.4 h, respectively.
Utility of single photon emission computed tomography perfusion scans in radiation treatment planning of locally advanced lung cancers

Purpose: Lung perfusion scan provides a map of the spatial distribution of lung perfusion. This can be used to design radiation portals to spare functional lung (FL), potentially reducing lung toxicity. The purpose of this study was to assess the utility of lung perfusion single photon emission computed tomography (SPECT) in treatment planning for lung cancer patients. Materials and Methods: Radiotherapy treatment planning computed tomography (CT) scans and SPECT scans of 11 patients of lung cancer suitable for external radiotherapy were co-registered. Conventional treatment plans (anatomic plan) and plans with FL information (functional plan) was generated. The difference in dose volume parameters (V20, V30 and mean lung doses) due to these two plans were compared using Bland-Altman plots. Results: Functional plans produced a more favorable plan compared with anatomic plan in all except three cases. FL V20 values and FL mean lung dose were reduced for all patients by an average of 5.45 Gy and 7.72 Gy respectively which were statistically significant. Conclusions: Lung perfusion scans provide functional information which is not provided by CT scans. SPECT-guidance aids in reducing the dose delivered to highly perfused regions which could reduce the incidence of pneumonitis.
Flexible Energy‐Storage Devices: Design Consideration and Recent Progress

Flexible energy‐storage devices are attracting increasing attention as they show unique promising advantages, such as flexibility, shape diversity, light weight, and so on; these properties enable applications in portable, flexible, and even wearable electronic devices, including soft electronic products, roll‐up displays, and wearable devices. Consequently, considerable effort has been made in recent years to fulfill the requirements of future flexible energy‐storage devices, and much progress has been witnessed. This review describes the most recent advances in flexible energy‐storage devices, including flexible lithium‐ion batteries and flexible supercapacitors. The latest successful examples in flexible lithium‐ion batteries and their technological innovations and challenges are reviewed first. This is followed by a detailed overview of the recent progress in flexible supercapacitors based on carbon materials and a number of composites and flexible micro‐supercapacitors. Some of the latest achievements regarding interesting integrated energy‐storage systems are also reviewed. Further research direction is also proposed to surpass existing technological bottle‐necks and realize idealized flexible energy‐storage devices.
Association of Comorbid Mental Health Symptoms and Physical Health Conditions With Employee Productivity

Objective: This study tests the hypothesis that employees with comorbid physical health conditions and mental health symptoms are less productive than other employees. Methods: Self-reported health status and productivity measures were collected from 1723 employees of a national retail organization. &khgr;2, analysis of variance, and linear contrast analyses were conducted to evaluate whether health status groups differed on productivity measures. Multivariate linear regression and multinomial logistic regression analyses were conducted to analyze how predictive health status was of productivity. Results: Those with comorbidities were significantly less productive on all productivity measures compared with all other health status groups and those with only physical health conditions or mental health symptoms. Health status also significantly predicted levels of employee productivity. Conclusion: These findings provide evidence for the relationship between health statuses and productivity, which has potential programmatic implications.
Identification and molecular characterization of two tandemly located flagellin genes from Aeromonas salmonicida A449

Two tandemly located flagellin genes, flaA and flaB, with 79% nucleotide sequence identity were identified in Aeromonas salmonicida A449. The fla genes are conserved in typical and atypical strains of A. salmonicida, and they display significant divergence at the nucleotide level from the fla genes of the motile species Aeromonas hydrophila and Aeromonas veronii biotype sobria. flaA and flaB encode unprocessed flagellins with predicted Mrs of 32,351 and 32,056, respectively. When cloned under the control of the Ptac promoter, flaB was highly expressed when induced in Escherichia coli DH5alpha, and the FlaB protein was detectable even in the uninduced state. In flaA clones containing intact upstream sequence, FlaA was barely detectable when uninduced and poorly expressed on induction. The A. salmonicida flagellins are antigenically cross-reactive with the A. hydrophila TF7 flagellin(s) and evolutionarily closely related to the flagellins of Pseudomonas aeruginosa and Vibrio anguillarum. Electron microscopy showed that A. salmonicida A449 expresses unsheathed polar flagella at an extremely low frequency under normal laboratory growth conditions, suggesting the presence of a full complement of genes whose products are required to make flagella; e.g., immediately downstream of flaA and flaB are open reading frames encoding FlaG and FlaH homologs.
School of IT Technical Report DECISION TREES FOR IMBALANCED DATA SETS TECHNICAL REPORT

We propose a new variant of decision tree for imbalanced classification. Decision trees use a greedy approach based on information gain to select the attribute to split. We express information again in terms of confidence and show that like confidence, information gain is biased towards the majority class. We overcome the bias of information gain by embedding a new measure, the ratio of confidence of the minority and majority class, into the entropy formula. Furthermore we prune the decision tree using p-value instead of the conventional error-based approach. Together these two changes yield a decision tree which is robust to imbalanced data. Extensive experiments and comparision against C4.5, CBA and variants on imbalanced and balance data confirm our claims.
Impacts of Woodland Fragmentation on Species’ Occurrences – The Combination of a Habitat Model with Landscape Metrics

Habitat fragmentation can be defined as the modification of once natural habitats into smaller, isolated subareas surrounded by other types of habitat (more or less hostile; the matrix; e. g. Valladares et al., 2006). Fragmentation includes both, the separation of habitats and habitat loss, but the most dramatic and consistently negative effects on biodiversity can be attributed to habitat loss (Fahrig, 2003). In our central European man-made landscape more and more habitats become destroyed or fragmented because of the increasing anthropogenic need of available land and despite the growing knowledge about the problem. Roads, residential, and industrial areas separate formerly connected habitats into small remnants and thus create small subpopulations. Accordingly, habitat fragmentation and the associated effects like (1) the biodiversity decline of stenotopic species in smaller habitats (Desender et al., 1999; Magura et al., 2001), (2) the loss of genetic diversity and variability (Debinski & Holt, 2000; Keller & Largiader, 2003), and (3) a higher probability of inbreeding in smaller populations, belong to the main reasons for extinction of species (Groom et al., 2006). Especially stenotopic species with low dispersal power are endangered because the exchange of specimen between different habitat patches is reduced or entirely inhibited (Hanski et al., 1995). Thus, standardised, comprehensible quantification methods of fragmentation are greatly important for the development of management and conservation plans for habitat networks.
Kinect and Optimization Algorithm Based Mobile Robot Path Planning in Dynamic Environment

Based on environmental awareness and effective path planning algorithm, effective robot path planning can be achieved. In this paper, the Kinect sensor, the latest vision sensing technology, is used to perceive the obstacles and terrain information in dynamic environment in real-time, which enables robots to realize effective path planning tasks in complex dynamic environment. Using the real-ime RGB image and 3D image produced by the Kinect sensor, the mobile robot peripheral environment information can be probed. The improved artificial potential field path planning algorithm is optimized by genetic trust method. As a result, it can solve the local minimum points and target unreachable problems in the traditional artificial potential field algorithm. Moreover, it can effectively improve the real-time performance of the algorithm, and eventually realize the optimization of real-time path planning tasks for a robot in dynamic environment. Finally, the experimental system is set up to verify the effectiveness of the proposed methods.
Faster Maximum Likelihood Estimation Algorithms for Markovian Arrival Processes

This paper proposes two improvements of fitting algorithms for Markovian arrival processes (MAPs). The first improvement is to enhance the computation speed of Ryd\'en's EM algorithm (1996) for estimating MAP parameters. The second one is to provide an efficient sub-class of MAPs to be appropriate for fitting to real traffic data. More precisely, we propose a traffic modeling based on a hidden Markov model which belongs to a sub-class of MAPs. Such a modeling framework leads to a faster fitting algorithm than the conventional algorithm with general MAPs. In numerical examples, we present the effectiveness of proposed fitting algorithms through a real traffic trace.
Women's Stress, Depression, and Relationship Adjustment Profiles as They Relate to Intimate Partner Violence and Mental Health During Pregnancy and Postpartum.

OBJECTIVE This study applied latent class analysis to examine whether homogeneous subgroups of women emerged based on their self-reported stress, depression, and relationship adjustment during pregnancy. We also examined whether women in different groups experienced different intimate partner violence (IPV) and mental health symptoms during pregnancy and postpartum. METHOD 180 women completed assessments during the first 18 weeks of pregnancy and 122 completed follow-up assessments six weeks postpartum. RESULTS A two-class solution best fit the data. One group reported higher mean stress and depression and poorer relationship adjustment compared to the other group. The high severity class reported more psychological IPV victimization and perpetration and more physical IPV victimization during pregnancy compared to the low severity class. Membership in the high severity class was associated with higher postpartum depression. CONCLUSIONS Findings highlight the associations between different profiles of mental and relational health during pregnancy and postpartum. Future studies should explore the utility of dyadic interventions aimed at reducing stress, depression, and IPV, and improving relationship adjustment as a means to improve women's health during pregnancy and postpartum. These findings also highlight the potential utility of applying person-centered analytic approaches to the study of women's and couples' health during this time period.
Symbol Error Performance Analysis of OFDM Receiver with Pulse Blanking over Frequency Selective Fading Channel

—Pulse blanking is a widely used method to eliminate impulsive interference in orthogonal frequency division multiplexing (OFDM) receiver. To analyze the effect of Inter Carrier Interference (ICI) caused by pulse blanking on the performance of symbol error rate (SER) for OFDM receiver, the analytical expression of signal to noise ratio (SNR) for OFDM receiver with pulse blanking is derived. The SER of OFDM receiver with pulse blanking over AWGN, Rayleigh and Ricean fading channel are also analyzed quantitatively based on the SNR expression. Simulation results validate the accuracy of our derived formulas.
Effect of Tetracycline on Retention of Calcium and Strontium in Rodents.∗

Summary Tetracycline (TC) administered repeatedly in doses totaling as much as 1200 mg/kg body weight, by either the intramuscular or intraperitoneal route, had no significant effect on the body retention of either Ca47 or Sr85 injected into mice or rats. Nor were the amounts of these radionuclides found in the bones reduced by such treatment. Oxytetracycline (OTC) was shown to have a greater chemical affinity for calcium ions than for strontium ions in vitro. Repeated large doses of OTC in the toxic range stunted the growth of young rats and caused pathological changes in bone tissue resembling those observed in hyperparathyroidism. Although TC and OTC in large amounts can alter the normal metabolic interrelationships between calcium ions and bone tissue, they have no significant value as agents for reducing a potentially hazardous body or skeletal burden of radiostrontium. We wish to acknowledge the valuable technical assistance of E. Flynn, M. Hepler, E. James, P. Suzuki, R. Hamel and G. Burdick.