Miracle-dz/UniFAR-FTUs huggingface dataset:
The Epstein-Barr Virus (EBV)-Induced Tumor Suppressor MicroRNA MiR-34a Is Growth Promoting in EBV-Infected B Cells

ABSTRACT Epstein-Barr virus (EBV) infection of primary human B cells drives their indefinite proliferation into lymphoblastoid cell lines (LCLs). B cell immortalization depends on expression of viral latency genes, as well as the regulation of host genes. Given the important role of microRNAs (miRNAs) in regulating fundamental cellular processes, in this study, we assayed changes in host miRNA expression during primary B cell infection by EBV. We observed and validated dynamic changes in several miRNAs from early proliferation through immortalization; oncogenic miRNAs were induced, and tumor suppressor miRNAs were largely repressed. However, one miRNA described as a p53-targeted tumor suppressor, miR-34a, was strongly induced by EBV infection and expressed in many EBV and Kaposi's sarcoma-associated herpesvirus (KSHV)-infected lymphoma cell lines. EBV latent membrane protein 1 (LMP1) was sufficient to induce miR-34a requiring downstream NF-κB activation but independent of functional p53. Furthermore, overexpression of miR-34a was not toxic in several B lymphoma cell lines, and inhibition of miR-34a impaired the growth of EBV-transformed cells. This study identifies a progrowth role for a tumor-suppressive miRNA in oncogenic-virus-mediated transformation, highlighting the importance of studying miRNA function in different cellular contexts.
Movember: Twitter Conversations of a Hairy Social Movement

Movember is an annual “month-long celebration of the moustache” where men grow a mustache and raise money in the largest philanthropic endeavor for men’s health. Movember is predominantly an online campaign, and consequently, participants have actively embraced social media; this is evidenced in the 1,879,994 tweets collected during Movember 2012 in this research project. This article presents an analysis of Movember that examines how individuals use the numerous syntactical features of Twitter to engage in conversation and share information in order to develop a nuanced understanding of how people are utilizing social media as part of the social movement. While Movember has been successful in gaining traction on social media, the Twitter data point to surprising conclusions that have implications for understanding non-profits and social movements online. The following study provides two main contributions to existing sociotechnical social movement literature using a mixed-methods approach. First, the findings suggest that there is limited true conversation taking place although the stated purpose of the campaign is to facilitate conversation. Second, the findings identify that participants are more engaged with Movember as a branded movement than engaged in health promotion. While the tweets are conversational in form, they are largely not conversational in function, which points to Twitter being used as a broadcast tool in this context. These findings have broad implications for understanding how social media is used to engage individuals in social campaigns and engage with each other and share information.
When Is a Set of LMIs a Sufficient Condition for Stability?

We study stability criteria for discrete time switching systems. We investigate the structure of sets of LMIs that are a sufficient condition for stability (i.e., such that any switching system which satisfies these LMIs is stable). We provide an exact characterization of these sets. As a corollary, we show that it is PSPACE-complete to recognize whether a particular set of LMIs implies the stability of a switching system.
Characterization of Mesonephric Development and Regeneration Using 2 Transgenic Zebrafish 3 4

1 Departments of Pediatrics and of Human Genetics, Howard Hughes Medical Institute, 7 University of Michigan, Ann Arbor, MI, USA 8 Leibniz Institute for Age Research, Fritz Lipmann Institute, 07745 Jena, Germany 9 *Current address: Hannover Medical School, Institute for Clinical Chemistry, OE 8110, 10 Carl-Neuberg-Str. 1, D-30625 Hannover, Germany 11 12 Running Head: Mesonephric Development and Regeneration in Zebrafish 13 14 15 Correspondence should be addressed to: 16 Friedhelm Hildebrandt, M.D. 17 University of Michigan Health System 18 8220C MSRB III, 1150 West Medical Center Drive 19 Ann Arbor, MI 48109-5646, USA 20 Phone: +1 734 615-7285 (office), +1 734 615-7895, -7896 (laboratories) 21 Fax: +1 734-615-1386, -7770 22 Articles in PresS. Am J Physiol Renal Physiol (September 1, 2010). doi:10.1152/ajprenal.00394. 2010
Uniform node sampling service robust against collusions of malicious nodes

We consider the problem of achieving uniform node sampling in large scale systems in presence of a strong adversary. We first propose an omniscient strategy that processes on the fly an unbounded and arbitrarily biased input stream made of node identifiers exchanged within the system, and outputs a stream that preserves Uniformity and Freshness properties. We show through Markov chains analysis that both properties hold despite any arbitrary bias introduced by the adversary. We then propose a knowledge-free strategy and show through extensive simulations that this strategy accurately approximates the omniscient one. We also evaluate its resilience against a strong adversary by studying two representative attacks (flooding and targeted attacks). We quantify the minimum number of identifiers that the adversary must insert in the input stream to prevent uniformity. To our knowledge, such an analysis has never been proposed before.
Image Segmentation Using Parametric Contours With Free Endpoints

In this paper, we introduce a novel approach for active contours with free endpoints. A scheme for image segmentation is presented based on a discrete version of the Mumford-Shah functional where the contours can be both closed and open curves. Additional to a flow of the curves in normal direction, evolution laws for the tangential flow of the endpoints are derived. Using a parametric approach to describe the evolving contours together with an edge-preserving denoising, we obtain a fast method for image segmentation and restoration. The analytical and numerical schemes are presented followed by numerical experiments with artificial test images and with a real medical image.
Muted Anger in the Workplace: Changing the 'Sound' of Employee Emotion Through Social Sharing

This study is a preliminary effort to examine “muted anger” in the workplace. Muted anger is a unique interpersonal and organizational phenomenon, incorporated in the Dual Threshold Model (DTM) of workplace anger (Geddes & Callister, 2007). Characterized as a form of suppressed workplace anger, muted anger occurs when angry organizational members intentionally keep their anger hidden from management and those responsible for the problematic situation, and instead express their emotions to colleagues (and others) unrelated to the initial anger-provoking incident. Using the DTM framework, we surveyed 296 full-time employees regarding their experience with an angry colleague who vented to them after an infuriating event. Our findings indicate that whether or not muted anger episodes can lead to productive communication practices depends on the anger intensity of both the actor and the sympathetic responder as well as the responder's level of organizational commitment. Those who themselves felt moderate anger intensity after hearing their colleague's plight and those with high organizational commitment were more likely to advocate on behalf of their angry colleague and approach management or someone in a responsible position to help address the problematic situation. Those with lower anger intensity and organizational commitment typically discussed the situation with one or two additional, but unrelated persons – expanding the muted anger episode.
On-Chip Event Debugger (OCeD) with Automated Code Execution Engine for Control Flow Detection

A custom designed on-chip event debugger (OCeD) has been proposed for the automation of the user-defined code flow detection. Conventional on-chip code debugging is performed by controlling the instruction execution with line-by-line break- points. An event-driven breakpoint concept is adopted to trace the collection of multiple triggered breakpoints using a built-in hardware-in-the-loop methodology. The tracer unit in the OCeD saves abstract trees of code access flow of interest in real time to search multiple conditions as an event breakpoint. The OCeD unit acquires the system control in detecting the user-defined event as multiple matched breakpoints through runtime execution of an entire firmware code and reports the traced flow graph to the host side. The OCD-to-event translation converter is inserted between the original OCD and the debugger software to control the code debugging flow. The proposed OCeD hardware is integrated in the 8051-based microcontroller and evaluated with FPGA-based target system. The event-breakpoint description for DhrystoneTM benchmark enables that the verification of the code execution flow to be fully automated without any conventional line breakpoint.
Economic Evaluation of a Problem Solving Intervention to Prevent Recurrent Sickness Absence in Workers with Common Mental Disorders

Objectives Workers with common mental disorders (CMDs) frequently experience recurrent sickness absence but scientifically evaluated interventions to prevent recurrences are lacking. The objectives of this study are to evaluate the cost-effectiveness and cost-benefit of a problem solving intervention aimed at preventing recurrent sickness absence in workers with CMDs compared to care as usual. Methods An economic evaluation was conducted alongside a cluster-randomised controlled trial with 12 months follow-up. Treatment providers were randomised to either a 2-day training in the SHARP-at work intervention, i.e. a problem solving intervention, or care as usual. Effect outcomes were the incidence of recurrent sickness absence and time to recurrent sickness absence. Self-reported health care utilisation was measured by questionnaires. A cost-effectiveness analysis (CEA) from the societal perspective and a cost-benefit analysis (CBA) from the employer’s perspective were conducted. Results The CEA showed that the SHARP-at work intervention was more effective but also more expensive than care as usual. The CBA revealed that employer’s occupational health care costs were significantly higher in the intervention group compared to care as usual. Overall, the SHARP-at work intervention showed no economic benefit compared to care as usual. Conclusions As implementation of the SHARP-at work intervention might require additional investments, health care policy makers need to decide if these investments are worthwhile considering the results that can be accomplished in reducing recurrent sickness absence.
Fourth-Order Dependency Parsing

We present and implement a fourth-order projective dependency parsing algorithm that effectively utilizes both “grand-sibling” style and “tri-sibling” style interactions of third-order and “grand-tri-sibling” style interactions of forth-order factored parts for performance enhancement. This algorithm requires O(n5) time and O(n4) space. We implement and evaluate the parser on two languages—English and Chinese, both achieving state-of-the-art accuracy. This results show that a higher-order (≥4) dependency parser gives performance improvement over all previous lower-order parsers.
Retargeting polymer‐coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human ovarian cancer

Transductional targeting of adenovirus following systemic or regional delivery remains one of the most difficult challenges for cancer gene medicine. The numerical excess and anatomical advantage of normal (non‐cancer) cells in vivo demand far greater detargeting than is necessary for studies using single cell populations in vitro, and this must be coupled with efficient retargeting to cancer cells.
Differences in Performance of ADHD Children on a Visual and Auditory Continuous Performance Test according to IQ

Objective Continuous performance tests (CPTs) are frequently used in clinical practice to assess the attentiveness of ADHD children. Although most CPTs do not categorize T scores by intelligence, there is great diversity of opinion regarding the interrelation between intelligence and CPT performance. This study aimed to determine if ADHD children with superior IQs would perform better than ADHD children with average IQs. Additionally, we aimed to examine the need for CPTs' to categorize according to IQ. Methods Participants were 326 outpatients, aged 5-15 years, diagnosed with ADHD. All participants completed the Wechsler Intelligence Scale for Children-Revised and a CPT. After excluding those who meet exclusion criteria, we had 266 patients for our analysis. Results The "Highly Intelligent Group" (HIG), patients with IQs 120 and above, performed superiorly to the "Normally Intelligent Group" (NIG) patients, with IQs between 70 and 120, with regard to omission and commission errors on the visual-auditory CPT, even after controlling for age and gender. The HIG had higher ratios of subjects with T scores <65 on the visual and auditory CPT variables than the NIG did. Conclusion The results of this study suggest this CPT is not sensitive for discerning ADHD in children with superior IQs; thus, there is a need to standardize the variables based on IQ, as well as on age and gender. Moreover, clinicians need to pay attention to the effect of IQ in interpreting CPT scores; that is, a "normal" score does not rule out a diagnosis of ADHD.
Development of the auditory evoked potential to amplitude rise time and rate of formant transition of speech sounds

We investigated the morphology of the N1-P2 auditory evoked potential (AEP) to changes in amplitude rise time (ART) and rate of formant transition (RFT) of consonant-vowel pairs (CVs) in 4-6-year olds and adults. In the AEP session, individuals listened passively to the CVs /ba/, /wa/, and a /ba/ with a superimposed slower-rising /wa/ envelope (/ba/wa). In the behavioral session, individuals listened to the same stimuli and judged whether they heard a /ba/ or /wa/. In 6-year olds and adults, the N1-P2 amplitude reflected a change in RFT (/ba/wa and /wa/) but not in ART (/ba/ and /ba/wa). In contrast, in the 4-5-year olds, the poorly developed N1-P2 did not show specificity to changes in RFT or ART. Behaviorally, 6-year olds and adults relied more strongly on RFT cues (classified /ba/wa as /ba/) during phonetic judgments, as opposed to 4-5-year olds which utilized both cues equally (chance level). Our findings suggest that following age 4-5, the development of the N1-P2 AEP, representing maturation of syna.
3-D Mesh Geometry Compression With Set Partitioning in the Spectral Domain

This paper explains the development of a highly efficient progressive 3-D mesh geometry coder based on the region adaptive transform in the spectral mesh compression method. A hierarchical set partitioning technique, originally proposed for the efficient compression of wavelet transform coefficients in high-performance wavelet-based image coding methods, is proposed for the efficient compression of the coefficients of this transform. Experiments confirm that the proposed coder employing such a region adaptive transform has a high compression performance rarely achieved by other state of the art 3-D mesh geometry compression algorithms. A new, high-performance fixed spectral basis method is also proposed for reducing the computational complexity of the transform. Many-to-one mappings are employed to relate the coded irregular mesh region to a regular mesh whose basis is used. To prevent loss of compression performance due to the low-pass nature of such mappings, transitions are made from transform-based coding to spatial coding on a per region basis at high coding rates. Experimental results show the performance advantage of the newly proposed fixed spectral basis method over the original fixed spectral basis method in the literature that employs one-to-one mappings.
Final Project-Eroding General 3 D Parts Submitting :

3D printing as a manufacturing system o ers new possibilities for designers. A key feature of it is the ability to print fully assembled mechanisms, while maintaining functionality. Due to the process of 3D printing, in order to create a mechanism some tolerance must be left between the parts, in order for them not to stick together. This tolerance changes from printer to printer. As such, a solution for eroding (insetting) general 3D parts is needed, to prepare these mechanisms to be 3D printed, instead of manufactured in old methods. In this project, I've implemented a general 3D part inserter. I've implemented it via two approaches, Nef polyhedra and Gaussian Maps, which will be discussed and compared. Also, validation of the desired o set, in order to prevent mistakes and enable automation will be discussed and implemented. Finally, a proof of concept for using this solution to print a 3D puzzle, The Gordian Knot, will be presented.
Resuscitation of Polytrauma Patients: The Management of Massive Skeletal Bleeding

The term ‘severely injured patient’ is often synonymous of polytrauma patient, multiply-injured patient or, in some settings, polyfractured patient. Together with brain trauma, copious bleeding is the most severe complication of polytrauma. Consequently hypotension develop. Then, the perfusion of organs may be compromised, with the risk of organ failure. Treatment of chest bleeding after trauma is essential and is mainly addressed via surgical manoeuvres. As in the case of lesions to the pelvis, abdomen or extremities, this approach demonstrates the application of damage control (DC). The introduction of sonography has dramatically changed the diagnosis and prognosis of abdominal bleeding. In stable patients, a contrast CT-scan should be performed before any x-ray projection, because, in an emergency situation, spinal or pelvic fractures be missed by conventional radiological studies. Fractures or dislocation of the pelvis causing enlargement of the pelvic cavity, provoked by an anteroposterior trauma, and in particular cases presenting vertical instability, are the most severe types and require fast stabilisation by closing the pelvic ring diameter to normal dimensions and by stabilising the vertical shear. Controversy still exists about whether angiography or packing should be used as the first choice to address active bleeding after pelvic ring closure. Pelvic angiography plays a significant complementary role to pelvic packing for final haemorrhage control. Apart from pelvic trauma, fracture of the femur is the only fracture provoking acute life-threatening bleeding. If possible, femur fractures should be immobilised immediately, either by external fixation or by a sheet wrap around both extremities.
On the classification of finite-dimensional pointed Hopf algebras

We classify finite-dimensional complex Hopf algebras A which are pointed, that is, all of whose irreducible comodules are one-dimensional, and whose group of group-like elementsG.A/ is abelian such that all prime divisors of the order of G.A/ are> 7. Since these Hopf algebras turn out to be deformations of a natural class of generalized small quantum groups, our result can be read as an axiomatic description of generalized small quantum groups.
KnowNet: Building a Large Net of Knowledge from the Web

This paper presents a new fully automatic method for building highly dense and accurate knowledge bases from existing semantic resources. Basically, the method uses a wide-coverage and accurate knowledge-based Word Sense Disambiguation algorithm to assign the most appropriate senses to large sets of topically related words acquired from the web. KnowNet, the resulting knowledge-base which connects large sets of semantically-related concepts is a major step towards the autonomous acquisition of knowledge from raw corpora. In fact, KnowNet is several times larger than any available knowledge resource encoding relations between synsets, and the knowledge KnowNet contains outperform any other resource when is empirically evaluated in a common framework.
Tackling long duration transients in sequential logic

Single Event Transients (SETs) in combinational logic remain to be an important topic in the reliability domain. SETs were traditionally relatively short in comparison to the clock period. The majority of the countermeasures utilizes this property. However, advances in technology scaling will reverse the ratio. Investigations show that SETs may last up to multiple clock cycles in the future. So called Long Duration Transients (LDTs) corrupt almost all available countermeasures. This work presents a new methodology to tackle LDTs. Dual Modular Redundancy (DMR) is used to detect any corruption of the application logic. A new micro-rollback scheme is introduced, that expands DMR-Architectures with correction capabilities. The concept is also capable of handling single event upsets and timing violations. The scheme utilizes a newly designed History Cell. The History Cell introduces an area overhead of 74% and a power overhead of 106% compared to a standard cell D-flip-flop. Area and power overheads for expanding an existing DMR-Architecture with correction capabilities are approximately 24% and 28%, respectively.
Text data mining: discovery of important keywords in the cyberspace

This paper describes applications of the optimized pattern discovery framework to text and Web mining. In particular, we introduce a class of simple combinatorial patterns over phrases, called proximity phrase association patterns, and consider the problem of finding the patterns that optimize a given statistical measure within the whole class of patterns in a large collection of unstructured texts. For this class of patterns, we develop fast and robust text mining algorithms based on techniques in computational geometry and string matching. Finally, we successfully apply the developed text mining algorithms to the experiments on interactive document browsing in a large text database and keyword discovery from Web bases.
Realizing the Dream: African American Males’ Narratives that Encouraged the Pursuit of Doctoral Education

This article used personal narratives to discover factors affecting the decision of African American males to consider doctoral education. This study was based on qualitative interviews with 18 African American male doctoral students enrolled at predominantly white institutions as they reflected on their reasons for pursuing an advanced degree. The following were found to influence their decision: (a) need for faculty encouragement, (b) motivation to pursue a doctorate, and (c) their personal motivations. Recommendations are offered for increasing the numbers of African American male doctoral students.
Practical Successive Interference Cancellation in the Binary-Input Gaussian Multiple-Access Channel

In the multiple access channel, successive interference cancellation (SIC) can be used to achieve the boundary points of the capacity region. In this paper, we investigate the practical potential of SIC by employing a set of practical moderate-blocksize Low-Density Parity-Check codes in the Multiple Access additive white Gaussian noise channel; in particular we consider binary modulation. The theoretically achievable points in the capacity region are compared with the practically achievable operating points at a low bit-error rate. It is shown that SIC makes available a higher transmission rate compared with simple separate detection that treats the signal of the other user as noise. This statement is also true for the use of binary modulation and a practical efficient implementation with channel codes of moderate blocksize.