Miracle-dz/UniFAR-FTUs huggingface dataset:
An 8 m/9.6 Gbps Underwater Wireless Optical Communication System

An 8 m/9.6 Gbps underwater wireless optical communication (UWOC) system based on a two-stage injection-locked 405 nm blue light laser diode (LD) transmitter with a 16-quadrature amplitude modulation (QAM)-orthogonal frequency-division multiplexing (OFDM) modulating signal is proposed and experimentally demonstrated. To the best of our knowledge, it is the first one that employs a two-stage injection-locked technique to improve the transmission performance of UWOC systems. With the assistance of an equalizer at the receiver site, acceptable bit error rate (BER) performance and a constellation map are obtained over an 8-m underwater link. Such a two-stage injection-locked 405 nm blue light LD transmitter-based UWOC system is shown to be a promising alternative, presenting its feasibility for long-range and high-speed underwater links.
A first step toward uncovering the truth about weight tuning in deformable image registration

Deformable image registration is currently predominantly solved by optimizing a weighted linear combination of objectives. Successfully tuning the weights associated with these objectives is not trivial, leading to trial-and-error approaches. Such an approach assumes an intuitive interplay between weights, optimization objectives, and target registration errors. However, it is not known whether this always holds for existing registration methods. To investigate the interplay between weights, optimization objectives, and registration errors, we employ multi-objective optimization. Here, objectives of interest are optimized simultaneously, causing a set of multiple optimal solutions to exist, called the optimal Pareto front. Our medical application is in breast cancer and includes the challenging prone-supine registration problem. In total, we studied the interplay in three different ways. First, we ran many random linear combinations of objectives using the well-known registration software elastix. Second, since the optimization algorithms used in registration are typically of a local-search nature, final solutions may not always form a Pareto front. We therefore employed a multi-objective evolutionary algorithm that finds weights that correspond to registration outcomes that do form a Pareto front. Third, we examined how the interplay differs if a true multi-objective (i.e., weight-free) image registration method is used. Results indicate that a trial-and-error weight-adaptation approach can be successful for the easy prone to prone breast image registration case, due to the absence of many local optima. With increasing problem difficulty the use of more advanced approaches can be of value in finding and selecting the optimal registration outcomes.
Innominate Artery Cannulation and Antegrade Cerebral Perfusion for Aortic Arch Reconstruction in Infants and Children

Purpose: Innominate artery cannulation has been widely adopted as a means to perform aortic arch reconstruction with continuous cerebral perfusion in the newborn. Although this technique has been subsequently utilized in infants and children, there is currently no data regarding the safety or efficacy in these older children. The purpose of this study was to review our experience with innominate artery cannulation for aortic arch reconstruction in patients beyond the neonatal period. Methods: This was a retrospective review of 42 infants and children who underwent aortic arch reconstruction using the technique of innominate artery cannulation with continuous cerebral perfusion. Of these procedures, 29 (69%) were primary arch reconstructions, while 13 (31%) were aortic arch reoperations. The median age at surgery was 8 months, and 22 patients underwent concomitant intracardiac repairs. Results: There was no operative mortality in this cohort of 42 patients undergoing aortic arch reconstruction. There was also no overt evidence of neurologic injury. Specifically, none of the patients demonstrated a neurologic deficit, clinical seizure, or unexpected delay in regaining a normal state of consciousness. The median duration of antegrade cerebral perfusion was 34 minutes. The median duration of hospital stay was 11 days. No patient required reoperation on the aortic arch with a median of 45-month follow-up. Conclusions: Innominate artery cannulation is a safe and effective technique for aortic arch reconstruction in nonneonates. We conclude that antegrade cerebral perfusion is a useful technique for aortic arch reconstruction in this patient population.
Potassium influx into maize root systems : influence of root potassium concentration and ambient ammonium.

Potassium influx into roots of dark-grown decapitated maize seedling (Zea mays L., cv Pioneer 3369A) was examined in presence and absence of ambient ammonium and at various root potassium concentrations. Six-day old seedlings which were dependent on the endosperm reserves for their energy source were exposed to KCl (labeled with (86)Rb) ranging from 5 to 200 micromolar. At both low (13 micromoles per gram fresh weight) and high (100 micromoles per gram fresh weight) root potassium concentration, isotherms indicated two potassium influx systems, one approaching saturation at 50 to 100 micromolar potassium and an additional one tentatively considered to be linear. A mixed-type inhibition by ammonium for the low-concentration saturable system was indicated by a concomitant decrease in V(max) and increase in K(m). High root potassium concentration decreased V(max) but had little effect on K(m) of this system. The rate constant for the second quasilinear system was decreased by ambient ammonium and by high root potassium status. Transfer of high potassium roots to potassium-free solutions resulted in an increase in influx within 2 hours; by 24 hours influx significantly exceeded that of roots not previously exposed to potassium. In roots of both low and high root potassium concentrations, potassium influx was restricted progressively as ambient ammonium increased to about 100 micromolar, but there was little further inhibition as ammonium concentrations increased beyond that to 500 micromolar. The data imply that potassium influx has two components, one subject to inhibition by ambient ammonium and one relatively resistant.
Profiling of Cytokines Secreted by Conventional Aqueous Outflow Pathway Endothelial Cells Activated In Vitro and Ex Vivo With Laser Irradiation.

PURPOSE To profile which cytokine genes are differentially expressed (DE) as up- or downregulated by cultured human trabecular meshwork (TMEs) and Schlemm's canal endothelial cells (SCEs) after three experimental treatments consisting of selective laser trabeculoplasty (SLT) irradiation, exposure to media conditioned either by SLT-irradiated TMEs (TME-cm) or by SCEs (SCE-cm). Also, to profile which cytokines are upregulated ex vivo in SLT-irradiated human conventional aqueous outflow pathway (CAOP) tissues. METHODS After each treatment, Affymetrix microarray assays were used to detect upregulated and downregulated genes for cytokines and their receptors in TMEs and SCEs. ELISA and protein antibody arrays were used to detect upregulated cytokines secreted in SLT-irradiated CAOP tissues ex vivo. RESULTS The SLT irradiation upregulated numerous cytokine genes in TMEs, but only a few in SCEs. Exposure to TME- and SCE-cm induced SCEs to upregulate many more cytokine genes than TMEs. Selective laser trabeculoplasty irradiation and exposure to TME-cm downregulated several cytokine genes in TMEs but none in SCEs. Selective laser trabeculoplasty irradiation induced one upregulated and three downregulated cytokine-receptor genes in TMEs but none in SCEs. Exposure to TME-cm induced upregulation of one and downregulation of another receptor gene in TMEs, whereas two unique cytokine-receptor genes were upregulated in SCEs. Cytokine protein expression analysis showed that at least eight cytokines were upregulated in SLT-irradiated human CAOP tissues in situ/ex vivo. CONCLUSIONS This study has helped us identify a cytokine signaling pathway and to consider newly identified mechanisms regulating aqueous outflow that may lay the foundation for the future development of cytokine-based glaucoma therapies.
A 5 GS/s 150 mW 10 b SHA-Less Pipelined/SAR Hybrid ADC for Direct-Sampling Systems in 28 nm CMOS

This paper presents a 28 nm CMOS 10 b SHA-less pipelined/SAR hybrid ADC, designed to enable a direct-sampling receiver system. To achieve low power at 5 GS/s, the ADC combines pipelined and SAR quantizers, powered at 1.8 V and 1 V, respectively. A 2.5 b 2-way time-interleaved 2.5 GS/s multiplying digital-to-analog converter (MDAC) is followed by an 8 b 8-way time-interleaved 625 MHz successive-approximation register (SAR). This architecture combines the benefits of both ADC topologies and allows significant power and complexity reduction. The high-speed 2.5 b MDAC front-end simplifies the complexity of time-interleaving (TI) and provides gain for attenuating the 8 b SAR non-idealities, when referred to the ADC input, relaxing its specifications and design. To further reduce power, the 2.5 b MDAC front-end is SHA-less, and an over-range calibration loop that allows operation at multi-GHz input is introduced. A calibration technique is also proposed to align the MDAC and SAR references, whose misalignment would otherwise produce integral non-linearity (INL) degradation. The ADC achieves -61.8 dB THD, 57.1 dB SNR for a 500 MHz input, while for a 2.35 GHz input it achieves -54.7 dB THD, 46.8 dB SNR (55.8 dB SNR excluding the integrated PLL contribution). The time-interleaving spur is 70 dBc. The ADC consumes 150 mW and occupies less than 0.5 mm2.
Antimicrobial substances produced by Staphylococcus aureus strains isolated from cattle in Brazil

Among 46 isolates of Staphylococcus aureus obtained from cattle in the State of Paraíba, Brazil, four were shown to produce antimicrobial substances (AMS). The two best AMS producers carried single plasmids of about 8·0 kbp and 50 kbp, respectively, which were designated pRJ34 and pRJ35. Curing experiments and molecular analysis associated the AMS production with the presence of these plasmids in the cells. The biochemical properties exhibited by the AMS suggested that they might be bacteriocins (Bac). The bacteriocin encoded by pRJ34 showed properties identical to those of the bacteriocins encoded by other small staphylococcal Bac plasmids. However, the bacteriocin encoded by the large plasmid pRJ35 has shown some properties which distinguish it from the other bacteriocins of Staph. aureus described so far, suggesting it may be a new member of the staphylococcal bacteriocin family.
Production of A and C variants of staphylococcal beta-lactamase by methicillin-resistant strains of Staphylococcus aureus

Most methicillin-resistant Staphylococcus aureus (MRSA) strains produce beta-lactamase. To determine whether this enzyme(s) is identical to one or more of the four beta-lactamases produced by methicillin-susceptible strains, the beta-lactamases of 50 MRSA isolates were typed by using substrate profile analysis. Forty type A, no type B, ten type C, and no type D beta-lactamase-producing strains were identified. The beta-lactamase inhibitor sulbactam reduced the MICs of beta-lactamase-labile antibiotics, including ampicillin, penicillin G, and cefazolin, for type A and type C MRSA strains.
A Test of a Modular , Wall Adapted Nonlinear Filter Model for Underresolved Flows

A . Stabilization using filters is intended to model and extract the energy lost to resolved scales due to nonlinearity breaking down resolved scales to unresolved scales. This process is highly nonlinear. We consider nonlinear filters which select eddies for damping (simulating breakdown) based on knowledge of how nonlinearity acts in real flow problems. The particular form of the nonlinear filter allows for easy incorporation of more knowledge into the filter process and its computational complexity is comparable to calculating a linear filter of similar form. Herein we show how to adapt nonlinear filters to the near wall region, adapting an idea of Nicoud and Ducros, give a convergence result for the wall-adapted method and give a test which shows eddy viscosity can be highly localized and produce an excellent result.
The Effect of Longitudinal Stretching of Muscles and Nerve versus Deep Transverse Friction Massage in the Management of Patients with Carpal Tunnel Syndrome

Background and Purpose: Carpal tunnel syndrome (CTS) is a common source of hand numbness and pain. The goal of this study was to compare longitudinal stretching of muscles and nerve to deep transverse friction massage for decreasing pain and improving hand function in patients with chronic CTS. Subjects and Methods: Thirty patients, 25 to 40 years old, were included in this study and randomized into two groups: the first group (36.8 ± 0.262) followed a physical therapy program group receiving stretching of wrist and hand flexors in combination with ultrasound, strengthening exercises of wrist and hand flexors, and wrist splint, three sessions per week for 12 weeks; and the second group (35.9 ± 0.225) followed the physical therapy program of deep transverse friction massage on the carpal tunnel site at the wrist joint, with using ultrasonic therapy, strengthening exercises of wrist and hand flexors and wrist splint, three sessions per week for 12 weeks. Outcome measures were range of motion (ROM), pain using visual analog scale (VAS), and hand grip strength measured with a sphygmomanometer. Results: There was a significant difference in both groups in all outcome measures compared to baseline. Over stretching group showed significant difference at the end of study in terms of range of motion of wrist flexion, extension and strength of handgrip when compared to deep friction massage group P < 0.05. However, there is no significant difference between groups in pain. Discussion and Conclusion: This study showed that the effect of stretching exercises is more beneficial than deep transverse friction massage in the treatment of patients with CTS in decreasing the compression of the median nerve in the tunnel.
Book Review: Statistical Language Models for Information Retrieval by ChengXiang Zhai

Statistical language models have recently been successfully applied to many information retrieval problems. A great deal of recent work has shown that statistical language models not only achieve superior empirical performance, but also facilitate parameter tuning and provide a more principled way, in general, for modeling various kinds of complex and non-traditional retrieval problems.
All-trans Retinoic Acid Upregulates Reduced CD 38 Transcription in Lymphoblastoid Cell Lines from Autism Spectrum Disorder

Autism is a complex neurodevelopmental disorder characterized by high heritability and considerable genetic and clinical heterogeneity (1). The behavioral phenotype is distinguished by impairment in social interaction and communication, as well as restricted and stereotyped behaviors and interests (2). Translational evidence based on the function of oxytocin (OT) in contributing to affiliative behavior in the vole has prompted investigations of peptidergic hormones in human social behavior, including autism (3–5). Some, but not all, genetic association studies have suggested that the oxytocin receptor (6–10) contributes vulnerability to autistic spectrum disorder (ASD). Interestingly, plasma measurements of OT showed that there are significantly lower plasma OT levels in ASD-affected individuals than in nonaffected subjects (11). In addition, OT can be administered intranasally and enhances affiliative behaviors such as the trust game (12) and parochial altruism (13) as well as improving social cognition (14,15), for example, reading of the Eyes in the Mind test. We have shown that intranasal OT enhances electroencephalogram (EEG) mu suppression, an index of mirror neuron activity in nonclinical subjects (16) that shows deficits in ASD (17). The results of all these studies suggest that social deficits characteristic of autism (7,18) may be related to dysfunctional OT peptidergic neurotransmission. Recently, experiments with a mouse knockout of the CD38 gene demonstrated the role of this transmembrane glycoprotein, with ADP-ribosyl cyclase activity, in the mediation of OT release in
A 105dB-gain 500MHz-bandwidth 0.1Ω-output-impedance amplifier for an amplitude modulator in 65nm CMOS

Polar modulation, where a constant-amplitude phase signal is amplified by an efficient switched-mode power amplifier (PA) and an envelope signal is modulated at the drain of the PA, has been proven to improve efficiency and linearity of the PA system. However, the amplitude modulator (AM) used in such modulation systems must have wide bandwidth, low switching ripple and high efficiency. Although several AM structures have been reported the hybrid switching amplitude modulator (HSAM) shows excellent performance [1–3]. The HSAM consists of a linear amplifier as a voltage source and a switching amplifier as a dependant current source. The linear amplifier using voltage feedback defines output voltage with high frequency information in a bandwidth-expanded envelope signal and the switching amplifier using current feedback drives almost all the current to develop output voltage with the help of a current sensing circuit. If the current sensing circuit does not work well, it makes an offset to the switching amplifier and results in additional power consumption of the linear amplifier [2]. To meet a stringent spectral mask, low output impedance of the linear amplifier is needed [1]. In conclusion, wide bandwidth and low output impedance of the linear amplifier, and accurate current sensing are critical points in the design of the HSAM.
Use of Interior Gateway Protocol (IGP) Metric as a second MPLS Traffic Engineering (TE) Metric

This document describes a common practice on how the existing metric of Interior Gateway Protocols (IGP) can be used as an alternative metric to the Traffic Engineering (TE) metric for Constraint Based Routing of MultiProtocol Label Switching (MPLS) Traffic Engineering tunnels. This effectively results in the ability to perform Constraint Based Routing with optimization of one metric (e.g., link bandwidth) for some Traffic Engineering tunnels (e.g., Data Trunks) while optimizing another metric (e.g., propagation delay) for some other tunnels with different requirements (e.g., Voice Trunks). No protocol extensions or modifications are required. This text documents current router implementations and deployment practices.
The RADICLELESS1 gene is required for vascular pattern formation in rice

The molecular mechanisms through which the complex patterns of plant vascular tissues are established are largely unknown. The highly ordered, yet simple, striate array of veins of rice leaves represents an attractive system to study the dynamics underlying pattern formation. Here we show that mutation in the RADICLELESS1 (RAL1) gene results in distinctive vascular pattern defects. In ral1 embryonic scutella, secondary veins are absent and in the prematurely aborted and discontinuous primary veins, cells are misaligned to each other. In ral1 leaves, longitudinal and commissural (transverse) veins display altered spacing and the commissural veins additionally show atypical branching and interruptions in their continuity. The vascular pattern alterations of ral1 occur in the context of normally shaped leaf primordia. Anatomical inspection and analysis of the expression of the procambium specification marker Oshox1-GUS and of the auxin-inducible reporter DR5-GUS demonstrates that all the vascular patterning aberrations of ral1 originate from defects in the procambium, which represents the earliest identifiable stage of vascular development. Furthermore, the ral1 mutant is unique in that procambium formation in leaf primordium development is delayed. Finally, the ral1 vascular patterning distortions are associated with a defective response to auxin and with an enhanced sensitivity to cytokinin. ral1 is the first mutant impaired in both procambium development and vascular patterning to be isolated in a monocot species.
Shaping Regional Industry-Infrastructure Networks An Agent Based Modelling Framework

Around the world, Regional Development Authorities (RDA's) have the responsibility for sustainable regional industry-infrastructure network development. The structure, content and behaviour of these large scale socio-technical systems or lambda-systems, however, emerge from the operational, tactical and strategic decisions by a variety of other stakeholders over which the RDA has no control. A generic agent based modelling framework has been developed wherein (a) any lambda-system can be represented as a multi-agent system and (b) their evolution can be simulated subject to a variety of external regimes. Using this generic framework, the development of a real "greenfield" industry/infrastructure network in the Dutch Eemsdelta is modelled and simulated to support the RDA and other stakeholders involved. First results are presented.
Differential Requirement for PBP1a and PBP1b in In Vivo and In Vitro Fitness of Vibrio cholerae

ABSTRACT We investigated the roles of the Vibrio cholerae high-molecular-weight bifunctional penicillin binding proteins, PBP1a and PBP1b, in the fitness of this enteric pathogen. Using a screen for synthetic lethality, we found that the V. cholerae PBP1a and PBP1b proteins, like their Escherichia coli homologues, are each essential in the absence of the other and in the absence of the other's putative activator, the outer membrane lipoproteins LpoA and LpoB, respectively. Comparative analyses of V. cholerae mutants suggest that PBP1a/LpoA of V. cholerae play a more prominent role in generating and/or maintaining the pathogen's cell wall than PBP1b/LpoB. V. cholerae lacking PBP1b or LpoB exhibited wild-type growth under all conditions tested. In contrast, V. cholerae lacking PBP1a or LpoA exhibited growth deficiencies in minimal medium, in the presence of deoxycholate and bile, and in competition assays with wild-type cells both in vitro and in the infant mouse small intestine. PBP1a pathway mutants are particularly impaired in stationary phase, which renders them sensitive to a product(s) present in supernatants from stationary-phase wild-type cells. The marked competitive defect of the PBP1a pathway mutants in vivo was largely absent when exponential-phase cells rather than stationary-phase cells were used to inoculate suckling mice. Thus, at least for V. cholerae PBP1a pathway mutants, the growth phase of the inoculum is a key modulator of infectivity.
Single item stochastic lot sizing problem considering capital flow and business overdraft

This paper introduces capital flow to the single item stochastic lot sizing problem. A retailer can leverage business overdraft to deal with unexpected capital shortage, but needs to pay interest if its available balance goes below zero. A stochastic dynamic programming model maximizing expected final capital increment is formulated to solve the problem to optimality. We then investigate the performance of four controlling policies: ($R, Q$), ($R, S$), ($s, S$) and ($s$, $\overline{Q}$, $S$); for these policies, we adopt simulation-genetic algorithm to obtain approximate values of the controlling parameters. Finally, a simulation-optimization heuristic is also employed to solve this problem. Computational comparisons among these approaches show that policy $(s, S)$ and policy $(s, \overline{Q}, S)$ provide performance close to that of optimal solutions obtained by stochastic dynamic programming, while simulation-optimization heuristic offers advantages in terms of computational efficiency. Our numerical tests also show that capital availability as well as business overdraft interest rate can substantially affect the retailer's optimal lot sizing decisions.