Miracle-dz/UniFAR-FTUs huggingface dataset:
State of the Art in Planning for College and University Campuses: Site Planning and Beyond

Problem, research strategy, and findings: Colleges and universities have been planning their campuses for centuries, yet scholars have conducted little empirical research regarding the nature of campus planning in the United States. We review recent scholarship on campus planning, discovering that it is dominated by case studies (sometimes in edited collections) and some comparative studies. In this review we organize the literature into 3 geographic scales: the campus per se (or campus park), the campus–community interface, and the larger campus district. The literature addresses 5 topics: land use, design, sustainability, economic development, and collaboration. Most of the studies focus on research-oriented universities in metropolitan locations. The literature emphasizes how campus master planning can support student learning, how design and building guidelines can make a campus more cohesive, and how campuses are adopting sustainable development and operations. At the campus–community interface, the research documents how some colleges and universities have expanded beyond their traditional boundaries, invested in local economic development, and worked with their communities to improve transportation and reduce environmental impacts. Studies of campus district planning emphasize community adoption of development regulations and code enforcement procedures to reduce the impact of students living in nearby neighborhoods. The literature stresses the importance of partnerships, collaboration, and enhanced communications between the university and the community. Takeaway for practice: University planners should continue to focus on site design that reinforces student learning and environmental sustainability and on community interface planning that supports economic development and reduces environmental impacts. City planners should expand campus district planning to address a broad array of issues and opportunities. Both university and city planners should facilitate collaboration between their institutions. Scholars should study a wide range of colleges and universities, including 2-year as well as 4-year institutions and those in nonurban settings.
Excessive indoor tanning as a behavioral addiction: a literature review.

BACKGROUND Socially valorized, excessive indoor tanning can lead to dependence. This finding is based on the observations of many dermatologists, who report repeated failures in preventing their patients from visiting tanning cabins, despite the announcement of a diagnosis of malignant melanoma. OBJECTIVE The objective of this paper is to show that excessive indoor tanning can be included in the spectrum of addictive behavior. This review focuses on the clinical features, diagnosis, prevalence, etiology, treatment, prevention, and psychopathology of this disorder. METHODS A review of the medical literature was conducted using PubMed and Google Scholar and using the following key words alone or in combination: tanning, addiction, dependence, tanning bed, sun exposure, and solarium. We selected 41 English-language articles from 1974 to 2013. RESULTS Many excessive indoor tanners meet symptom criteria adapted from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) substance abuse and dependence criteria. Trial studies suggest that there may be a physiological basis, consisting of dependence on opioids, for excessive indoor tanning behaviors. CONCLUSION Excessive indoor tanning can be included in the spectrum of addictive behaviors, although other models may be proposed. Further controlled studies must be performed, especially in neurobiology and imaging, to improve our understanding of tanning dependence.
Local Injection of Antisense Oligonucleotides Targeted to the Glial Glutamate Transporter GLAST Decreases the Metabolic Response to Somatosensory Activation

The mechanisms responsible for the local increase in brain glucose utilization during functional activation remain unknown. Recent in vitro studies have identified a new signaling pathway involving an activation of glial glutamate transporters and enhancement of neuron–astrocyte metabolic interactions that suggest a putative coupling mechanism. The aim of the present study was to determine whether one of the glutamate transporters exclusively expressed in astrocytes, GLAST, is involved in the neurometabolic coupling in vivo. For this purpose, rats were microinjected into the posteromedial barrel subfield (PMBSF) of the somatosensory cortex with GLAST antisense or random phosphorothioate oligonucleotides. The physiologic activation was performed by stimulating the whisker-to-barrel pathway in anesthetized rats while measuring local cerebral glucose utilization by quantitative autoradiography in the PMBSF. Twenty-four hours after injection of two different antisense GLAST oligonucleotide sequences, and despite the presence of normal whisker-related neuronal activity in the PMBSF, the metabolic response to whisker stimulation was decreased by more than 50%. Injection of the corresponding random sequences still allowed a significant increase in glucose utilization in the activated area. The present study highlights the contribution of astrocytes to neurometabolic coupling in vivo. It provides evidence that glial glutamate transporters are key molecular components of this coupling and that neuronal glutamatergic activity is an important determinant of energy utilization. Results indicate that astrocytes should also be considered as possible sources of altered brain metabolism that could explain the distinct imaging signals observed in some pathologic situations
Deinococcus radiodurans PprI Switches on DNA Damage Response and Cellular Survival Networks after Radiation Damage*S

Preliminary findings indicate that PprI is a regulatory protein that stimulates transcription and translation of recA and other DNA repair genes in response to DNA damage in the extremely radioresistant bacterium Deinococcus radiodurans. To define the repertoire of proteins regulated by PprI and investigate the in vivo regulatory mechanism of PprI in response to γ radiation, we performed comparative proteomics analyses on wild type (R1) and a pprI knock-out strain (YR1) under conditions of ionizing irradiation. Results of two-dimensional electrophoresis and MALDI-TOF MS or MALDI-TOF/TOF MS indicated that in response to low dose γ ray exposure 31 proteins were significantly up-regulated in the presence of PprI. Among them, RecA and PprA are well known for their roles in DNA replication and repair. Others are involved in six different pathways, including stress response, energy metabolism, transcriptional regulation, signal transduction, protein turnover, and chaperoning. The last group consists of many proteins with uncharacterized functions. Expression of an additional four proteins, most of which act in metabolic pathways, was down-regulated in irradiated R1. Additionally phosphorylation of two proteins was under the control of PprI in response to irradiation. The different functional roles of representative PprI-regulated genes in extreme radioresistance were validated by gene knock-out analysis. These results suggest a role, either directly or indirectly, for PprI as a general switch to efficiently enhance the DNA repair capability and extreme radioresistance of D. radiodurans via regulation of a series of pathways.
Direct Measurement of Nitric Oxide Generation in the Ischemic Heart Using Electron Paramagnetic Resonance Spectroscopy (*)

Nitric oxide, NO, exerts numerous important regulatory functions in biological tissues and has been hypothesized to have a role in the pathogenesis of cellular injury in a number of diseases. It has been suggested that alterations in NO generation are a critical cause of injury in the ischemic heart. However, the precise alterations in NO generation which occur are not known, and there is considerable controversy regarding whether myocardial ischemia results in increased or decreased NO formation. Therefore, electron paramagnetic resonance studies were performed to directly measure NO in isolated rat hearts subjected to global ischemia, using the direct NO trap Fe-N-methyl-D-glucamine dithiocarbamate, which specifically binds NO giving rise to a characteristic triplet EPR spectrum with g = 2.04 and aN = 13.2 G. While only a small triplet signal was observed in normally perfused hearts, a 10-fold increase in this triplet EPR spectrum was observed after 30 min of ischemia indicating a marked increase in NO formation and trapping. Measurements were performed as a function of the duration of ischemia, and it was determined that with increased duration of ischemia NO formation and trapping was also increased. NO generation was inhibited by the nitric oxide synthase blocker, N-nitro-L-arginine methyl ester (L-NAME), suggesting that NO was generated via nitric oxide synthase. Blockade of NO generation with L-NAME resulted in more than a 2-fold increase in the recovery of contractile function in hearts reperfused after 30 min of global ischemia. Thus, ischemia causes a marked duration-dependent increase of NO in the heart which may in turn mediate postischemic injury.
Visual impairment and the useful field of vision

The aim of this study was to measure the useful field of vision (UFoV) in people with visual impairment and to compare results with clinical measures of vision. UFoV, visual acuity, contrast sensitivity and visual fields were measured in 36 participants with low vision and 22 age‐matched controls in two age groups. For both the low vision and control groups the presence of distractors (cluttered field) increased the error rates on our UFoV measure but there was no significant effect of the presence of a central task (divided attention). Participants with low vision made more errors on UFoV than did controls, but this difference disappeared once their visual field defects were accounted for. By multiple regression analysis, age, visual fields and contrast sensitivity were shown to predict the different UFoV scores. As for observers with normal vision, standard clinical visual field tests may not fully describe the difficulties that may be encountered by people with visual impairment undertaking tasks in the cluttered environments and multiple demands of everday life.
Mosaic of Difference

Summary The professional literature has not adequately addressed the behavioral and social factors that contribute to different coping outcomes for African American elder caregivers as compared to non African Americans. Awareness and understanding of these unique experiences would better prepare professionals to work with such clients. This study examines the predictors of emotional distress among 46 African American women who provide care to dependent elderly parents. Multivariate statistical analyses show that elder caregivers' rating of quality of life, their years of caregiving, as well are their poor heath constitute significant predictors of risk for depression. The results of the study provide support for the inclusion of more culturally appropriate measures of caregiver distress, and provide insights to inform social work practice, policy and research concerning African American female elder caregivers in the 21st century.
The Lytic Transcriptome of Kaposi's Sarcoma-Associated Herpesvirus Reveals Extensive Transcription of Noncoding Regions, Including Regions Antisense to Important Genes

ABSTRACT Genomewide analyses of the mammalian transcriptome have revealed that large tracts of sequence previously annotated as noncoding are frequently transcribed and give rise to stable RNA. Although the transcription of individual genes of the Kaposi's sarcoma-associated herpesvirus (KSHV) has been well studied, little is known of the architecture of the viral transcriptome on a genomewide scale. Here we have employed a genomewide tiling array to examine the lytic transcriptome of the Kaposi's sarcoma-associated herpesvirus, KSHV. Our results reveal that during lytic growth (but not during latency), there is extensive transcription from noncoding regions, including both intergenic regions and, especially, noncoding regions antisense to known open reading frames (ORFs). Several of these transcripts have been characterized in more detail, including (i) a 10-kb RNA antisense to the major latency locus, including many of its microRNAs as well as its ORFs; (ii) a 17-kb RNA antisense to numerous ORFs at the left-hand end of the genome; and (iii) a 0.7-kb RNA antisense to the viral homolog of interleukin-6 (vIL-6). These studies indicate that the lytic herpesviral transcriptome resembles a microcosm of the host transcriptome and provides a useful system for the study of noncoding RNAs.
Stereoselectivity of phosphotriesterase with paraoxon derivatives: a computational study

The bacterial enzyme phosphotriesterase (PTE) exhibits stereoselectivity toward hydrolysis of chiral substrates with a preference for the Sp enantiomer. In this work, docking analysis and two explicit-solvent molecular dynamics (MD) simulations were performed to characterize and differentiate the structural dynamics of PTE bound to the Sp and Rp paraoxon derivative enantiomers (Rp-1 and Sp-1) hydrolyzed with distinct catalytic efficiencies. Comparative analysis of the molecular trajectories for PTE bound to Rp-1 and Sp-1 suggested that substrate binding induced conformational changes in the loops near the active site. After 100 ns of MD simulation, the Zn β2+ metal ion formed hexacoordinated- and tetracoordinated geometries in the Sp-1-PTE and Rp-1-PTE ensembles, respectively. Simulation results further showed that the hydrogen bond between Asp301 and His254 occurred with a higher probability after Sp-1 binding to PTE (47.5%) than that after Rp-1 binding (22.2%). These results provide a qualitative and molecular-level explanation for the 10 orders of magnitude increase in the catalytic efficiency of PTE toward the Sp enantiomer of paraoxon.
Modelling China’s outbound tourist flow to the ‘Silk Road’: A spatial econometric approach

With the ancient Silk Road as the historical background, the ‘Belt and Road’ initiative aims to foster common development of regional economies. Regional tourism development is an essential part of the initiative. Taking 55 countries participating in the initiative as a research sample, the article investigates the determinants and spillover effect of Chinese outbound tourist flows by spatial panel models. Furthermore, we identify different spillover paths from the perspectives of geographic and cultural proximities. The results confirm that there exist significant positive spillover effects in tourist flows among countries with geographic proximity. Meanwhile, there exist significant positive spillover effects in tourist flows among countries with cultural proximity. In addition, geographic and cultural distances between China and tourist destinations have negative impacts on Chinese outbound tourist flow.
Induction of Stable Mixed Chimerism by Embryonic Stem Cells Requires Functional Fas/FasL Engagement

Background. Recent data show the efficacy of embryonic stem cells (ESC) to engraft in allogeneic recipients without host pretreatment. This property is due to their low expression of major histocompatibility complex (MHC) class I antigens and lack of MHC class II expression. Here, we tested the hypothesis that the constitutive FasL expression by ESC is a requirement for their stable engraftment in allogeneic recipients. Methods. MRL and MRL-lpr/lpr mice (H-2k) were infused allogeneic 129SvJ RW-4 (H-2b) ESC without host preconditioning. The development of mixed chimerism was monitored over 100 days by flow cytometry. Results. Mixed chimerism was detectable by day 7. The amount of donor cells detected varied between 3–5.5 % and were lymphoid, but nonmyeloid. Only 50% of lpr/lpr mice engrafted and lost donor cells by day 28 post-ESC infusion. In contrast, >80% wild type mice engrafted and maintained mixed chimerism up to day 100. Conclusions. These data suggest a critical role for Fas-FasL engagement in ESC engraftment. We conclude that ESC may induce clonal deletion of alloreactive T cells by Fas-induced apoptosis in recipient T cells, protecting them from rejection. The data provide a rationale for improved protocols for the achievement of robust ESC-induced mixed chimerism.
Micro-lending Default Awareness Using Artificial Neural Network

Lending ways plays as a key sector in banking business. In recent years, small amount lending, so-called micro-lending, has become the popular trend due to the prosperous development of internet financial service. The high profit has driven banks to bear the so-called credit risk that the borrower may default or delay the repayment of the loan. To prevent from or to predict the credit risk, there are many methodologies widely applied, such as the credit scoring system with credit score-card, the Logistic Regression (LR) for assessing repayment ability or linear scoring function like Bayesian Decision Rules for credit risk of lending. These traditional methods need substantial information to do the analysis of customer lending. However, for general public, the applicant's information of micro-lending is usually less complete, not to mention to fill out the information of score-card. If we applied the above traditional methods for credit risk measurement, the accuracy of predicting the default usually is not as expected due to the incompleteness of information. It is, therefore, studies on the credit-risk measurement of micro-lending have become crucial. In this paper, we proposed a new approach for credit-risk measurement of micro-lending. To learn the pattern of bad credit, the methodology of data cleaning and Back-Propagation Neural Network (BPN) are adopted. The dataset of loan information from a Brazilian commercial bank is used to run the process of credit default awareness. Based on the experiment outcomes, we proved that the Artificial Neural Network can significantly improve the accuracy of the perception while reducing the chance of misjudgment of the lending.
Can a comprehensive code of conduct discourage incivility in nursing students?

Background. This article discusses problems associated with incivility in nursing education and a proposed implementation strategy designed to decrease uncivil acts of student behavior. Problem description. Like most colleges across the nation, this nursing program was experiencing an increase in acts of student incivility. Operational definitions. Incivility, also called bullying, may include behaviors such as name calling, side conversations, and condescending language. Method. The sample consisted of 94 third-semester nursing students and 6 faculty members. The Incivility in Nursing Education survey was used as a tool to measure student and faculty perceptions. Data analysis. Data from pre- and postimplementation surveys demonstrated scientific evidence of both faculty and student perception and a significant decrease in acts of uncivil behavior in the nursing program. Limitations. Because the study was limited to one nursing program and included only third-semester nursing students, the results of the study may not be transferable to all nursing programs. Conclusions. The study revealed a reduction in perceived uncivil acts of behavior in the nursing program by faculty and students.
Anatomical Dissection and Modified Sihler Stain of the Lower Branches of the Facial Nerve

Background: The cervical branch of the facial nerve and the muscles it supplies play a role in perioral function and neck aesthetics. Paralysis of the cervical branch in some patients may result in lip depressor deficiency and an asymmetric smile. It is unclear whether this is the result of platysmal weakness alone, or attributable to coinnervation of the lip depressor muscles by the cervical and marginal mandibular branches of the facial nerve. The purpose of this study was to provide a detailed description of the anatomy and function of the cervical branch to assist surgeons operating in the face and neck. Methods: Anatomical dissection of the marginal mandibular and cervical branches was performed in 20 hemifacial human cadaver specimens. The modified Sihler stain was used to stain the extramuscular and intramuscular nerve branches in eight specimens. The course, branching patterns, and neuromuscular relationships of the cervical and marginal mandibular branches were examined. Results: Multiple cervical branches were identified in 85 percent of specimens, and an anastomosis with the transverse cervical cutaneous nerve was documented consistently. A communication between the marginal mandibular and cervical branches was identified in seven specimens, and coinnervation of the depressor anguli oris by intramuscular cervical branch ramifications was seen in one. Conclusions: A detailed description of the anatomy of the cervical branch is provided. Coinnervation of the lower lip depressors by the cervical branch remains a plausible explanation for the lower lip deformity attributed to cervical branch paralysis in some patients.
Nucleotide sequence analysis of RepFIC, a basic replicon present in IncFI plasmids P307 and F, and its relation to the RepA replicon of IncFII plasmids

RepFIC is a basic replicon of IncFI plasmid P307 which is located within a 3.09-kilobase SmaI fragment. The nucleotide sequence of this region has been determined and shown to be homologous with the RepFIIA replicon of IncFII plasmids. The two replicons share three homologous regions, HRI, HRII, and HRIII, which are flanked by two nonhomologous regions, NHRI and NHRII. A comparison of coding regions reveals that the two replicons have several features in common. RepFIC, like RepFIIA, codes for a repA2 protein with its amino-terminal codons in HRI and its carboxy-terminal codons in NHRI. Although the codons for the repA1 proteins are located in NHRII, the DNA region containing a putative promoter, ribosomal binding site, and initiation codons is located in HRII. This region also codes for an inc RNA. There are nine base-pair differences between the inc RNA of RepFIIA and that of RepFIC, and as a result, RepFIC and RepFIIA replicons are compatible. An EcoRI fragment from the F plasmid which shows homology with RepFIC of P307 has also been sequenced. This fragment contains only a portion of RepFIC, including the genes for the putative repA2 protein and inc RNA. The region coding for a putative repA1 protein is interrupted by the transposon Tn1000 and shows no homology with the repA1 region of RepFIIA and RepFIC of P307. Our comparative and structural analyses suggest that RepFIC and RepFIIA, although different, have a similar replication mechanism and thus can be assigned to the same replicon family, which we designate the RepFIIA family.
Complementarity in Product, Process, and Organizational Innovation Decisions: Evidence from European Firms

This work uses a sample of firm-level data from seven EU countries to explore the possible roles of simultaneity and heterogeneity in determining firms' decisions to engage in three types of innovation. Process, product, and organizational innovations are considered jointly, by applying a multivariate probit specification. The results support the hypothesis that the three innovation decisions are interdependent. This has straightforward implications for the practice of R&D managers. In order to gain advantages from an innovation, innovation managers need to jointly exploit these different types of innovation activities and their potential synergies. Given that the innovative firms in the sample, desire additional credit which actually they do not obtain, R&D managers should also be concerned with the financing sources firms have access to. Finally, from the analysis it also emerges that public support boost all the three forms of innovation.