Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality of life perception of basketball master athletes: association with physical activity level and sports injuries

Abstract This study aimed to verify the prevalence and characteristics of sports injuries (SI) and determine the association between the physical activity level (PA) and SI with perception of health-related quality of life (HRQoL) in Brazilian basketball master athletes. A cross-sectional study was conducted with 410 male master athletes, between 35 and 85 years of age (mean 52.26, SD ±11.83). The HRQoL was assessed using the Medical Outcomes Study – Short Form-36. The PA was evaluated using the International Physical Activity Questionnaire. Information regarding SI was collected using the Reported Morbidity Survey. Poisson regression, as estimated by the prevalence ratio (PR), was used as a measure of the association of PA and SI with HRQoL. The majority of athletes showed a high SI prevalence (58.3%) and reported one injury (67.8%) that occurred during training (61.1%) and primarily affected a lower limb (74.6%). The adjusted regression models showed a positive association of PA with the Functional Capacity (PR = 1.46, 95% confidence interval [CI] = 1.12–1.90) and Physical Component (PR = 1.32, 95% CI = 1.03–1.70) of HRQoL. Furthermore, the SI were negatively associated with HRQoL in Functional Capacity (PR = 1.85, 95% CI = 1.51–2.27), Physical Aspects (PR = 3.99, 95% CI = 3.08–5.18), Pain (PR = 1.65, 95% CI = 1.26–2.16), Social Functioning (PR = 1.79, 95% CI = 1.41–2.27), Emotional Aspects (PR = 4.40, 95% CI = 3.35–5.78), Mental Health domains (PR = 1.37, 95% CI = 1.06–1.68), Physical Component (PR = 2.35, 95% CI = 1.90–2.90) and Mental Component (PR = 2.65, 95% CI = 2.14–3.29). These results highlighted that master athletes showed a high SI prevalence, primarily in the lower limbs. PA positively correlates with the physical HRQoL domain, whereas SI may decrease the HRQoL levels of both physical and mental domains.
Spindle assembly checkpoint component CaMad2p is indispensable for Candida albicans survival and virulence in mice

Here, we report an indispensable role for spindle assembly checkpoint (SAC) component CaMad2p in the survival and virulence of Candida albicans in mice. We hypothesized that cell cycle checkpoint functions, especially those monitoring the integrity of DNA and chromosome segregation, might be required for the pathogen to repair damage caused by host defence. To test this idea, we created SAC‐defective mutants by deleting the CaMAD2 gene that encodes a key component of the SAC pathway. The CaMAD2 mutant appears normal in morphology, growth rate and growth mode switch in unperturbed conditions. However, it quickly loses viability when treated with nocodazole, which causes disassembly of mitotic spindles. The mutant also exhibits increased frequency of chromosome loss. The virulence of the mutant is greatly reduced in mice, presumably because of the inability of the mutant cells to stop the cell cycle when the host defence damages cellular components important for chromosome segregation. Supporting this hypothesis, unlike the wild‐type cells that can proliferate within and eventually grow out of macrophages, most of the CaMAD2 null mutant cells are unable to survive. This study suggests that SAC is required for survival of C. albicans in the host and could thus be targeted for anti‐C. albicans therapies.
Effects of a Supplementation during Exercise and Recovery

The present study was designed to investigate whether a protein hydrolysate enriched in branched chain amino acids and antioxidants, trace and mineral elements, and vitamins would affect performance and fatigue. Eighteen sportsmen underwent testing before and after 28 days supplementation with either treatment in protein hydrolysate or placebo. Testing included exhaustive aerobic and anaerobic exercises with determination of blood lactate concentration through exercise and recovery and antioxidant status, but also measurements of maximal oxidative capacity (V. (max)) and citrate synthase activity (CS) from a resting muscle biopsy. Protein hydrolysate resulted in a significant decrease in fatigue indices, without affecting performances. A significant increase in enzymatic antioxidant and a decrease in oxidative damage were observed at rest after treatment but not with a placebo. Decrease in maximal blood lactate and improvement of blood lactate removal were only observed after protein hydrolysate treatment. Furthermore, CS increased significantly, whereas no change was observed in V. (max). In conclusion, this protein hydrolysate treatment induced adaptations that may promote a decrease in fatigue during exercises, potentially explained by changes in parameters used to represent oxidative damage and antioxidant status at rest and changes in lactate metabolism.
Recognition of polyadenosine RNA by zinc finger proteins

Messenger RNA transcripts are coated from cap to tail with a dynamic combination of RNA binding proteins that process, package, and ultimately regulate the fate of mature transcripts. One class of RNA binding proteins essential for multiple aspects of mRNA metabolism consists of the poly(A) binding proteins. Previous studies have concentrated on the canonical RNA recognition motif-containing poly(A) binding proteins as the sole family of poly(A)-specific RNA binding proteins. In this study, we present evidence for a previously uncharacterized poly(A) recognition motif consisting of tandem CCCH zinc fingers. We have probed the nucleic acid binding properties of a yeast protein, Nab2, that contains this zinc finger motif. Results of this study reveal that the seven tandem CCCH zinc fingers of Nab2 specifically bind to polyadenosine RNA with high affinity. Furthermore, we demonstrate that a human protein, ZC3H14, which contains CCCH zinc fingers homologous to those found in Nab2, also specifically binds polyadenosine RNA. Thus, we propose that these proteins are members of an evolutionarily conserved family of poly(A) RNA binding proteins that recognize poly(A) RNA through a fundamentally different mechanism than previously characterized RNA recognition motif-containing poly(A) binding proteins.
Understanding Enterovirus 71 Neuropathogenesis and Its Impact on Other Neurotropic Enteroviruses

Enterovirus A71 (EV‐A71) belongs to the species group A in the Enterovirus genus within the Picornaviridae family. EV‐A71 usually causes self‐limiting hand, foot and mouth disease or herpangina but rarely causes severe neurological complications such as acute flaccid paralysis and encephalomyelitis. The pathology and neuropathogenesis of these neurological syndromes is beginning to be understood. EV‐A71 neurotropism for motor neurons in the spinal cord and brainstem, and other neurons, is mainly responsible for central nervous system damage. This review on the general aspects, recent developments and advances of EV‐A71 infection will focus on neuropathogenesis and its implications on other neurotropic enteroviruses, such as poliovirus and the newly emergent Enterovirus D68. With the imminent eradication of poliovirus, EV‐A71 is likely to replace it as an important neurotropic enterovirus of worldwide importance.
The role of self-efficacy and relationship quality in partner notification by adolescents with sexually transmitted infections.

OBJECTIVE To evaluate the role of self-efficacy, anticipated negative consequences, and relationship quality in patient-initiated sex partner notification following treatment for sexually transmitted infections. SUBJECTS Two hundred forty-one 13- to 20-year-old subjects (83% women; 83% African American) diagnosed with gonorrhea, chlamydia, trichomonas, or nongonococcal urethritis. Subjects were patients at a public sexually transmitted diseases clinic or primary care adolescent clinics. METHODS Structured interviews at enrollment and 1 month following treatment. At enrollment, recent sexual partners were identified. Coital frequency, partner-specific sexually transmitted infection notification self-efficacy, anticipated consequences of notification, and relationship quality were measured with multi-item scales. At 1 month, subjects were asked whether partners had been notified and about the timing of notification relative to treatment. RESULTS Subjects reported 279 partners. Of these, 61% of women's partners and 52% of men's partners were notified. Multiple logistic regression adjusted by generalized estimating equations showed that notification was predicted by antecedent notification self-efficacy (adjusted odds ratio, 1.16; 95% confidence interval, 1.03-1.30) and relationship quality (adjusted odds ratio, 1.17; 95% confidence interval, 1.08-1.27). Age, sex, race/ethnicity, prior sexually transmitted infection, coital frequency, and anticipated consequences were not related to partner notification. CONCLUSIONS Partner notification is increased among persons with higher levels of self-efficacy and in relationships with stronger affiliative and emotional ties. Self-efficacy and partner communication could be especially amenable to interventions to increase patient-initiated partner notification for curable sexually transmitted infections.
Daratumumab monotherapy compared with historical control data in heavily pretreated and highly refractory patients with multiple myeloma: An adjusted treatment comparison

Daratumumab is a human CD38‐directed monoclonal antibody approved in the United States as monotherapy for patients with multiple myeloma (MM) who have received ≥3 prior lines of therapy (LOTs), including a proteasome inhibitor (PI) and an immunomodulatory agent (IMiD) or who are double refractory to a PI and an IMiD, and in combination with lenalidomide/dexamethasone or bortezomib/dexamethasone for patients with MM who have received ≥1 prior LOT. This study compared the efficacy of daratumumab monotherapy versus historical controls through adjusted treatment comparison. Patient‐level data were pooled from two daratumumab monotherapy studies (16 mg/kg; GEN501 and SIRIUS) and two independent US databases (IMS LifeLink and OPTUM), which reflect treatments used in real‐world patients with MM who received ≥3 prior LOTs or were double refractory to a PI and an IMiD. Using a multivariate proportional hazards regression model, the relative treatment effect of daratumumab versus historical controls was estimated, adjusting for imbalances in characteristics between cohorts. Baseline characteristics that differed between patients treated with daratumumab (N = 148) and historical control (N = 658) were prior treatment with pomalidomide (55% vs 15%) or carfilzomib (41% vs 28%) and triple/quadruple refractory status (64% vs 14%). The adjusted overall survival–hazard ratio (OS‐HR) for daratumumab versus historical control was 0.33 (95% confidence interval, 0.24‐0.46) compared with 0.46 (0.35‐0.59) for unadjusted HR. Impact of adjustment was mainly driven by refractory status and prior pomalidomide/carfilzomib exposure. This adjusted treatment comparison suggests that daratumumab demonstrates improved OS compared with historical control data in heavily pretreated and highly refractory MM patients.
Human T-cell activation by 14- and 18-kilodalton nuclear proteins of Leishmania infantum

Leishmanial antigens which stimulate T lymphocytes from primed individuals may be candidates for a vaccine. We recently found a significant concordance between the humoral response specific for two proteins from Leishmania infantum promastigotes, p14 and p18, and a positive leishmanin delayed-type hypersensitivity reaction, testifying to the occurrence of cell-mediated immunity. In this communication, we describe a partial characterization of these antigens and an in vitro analysis of their capacity to activate primed human T cells. We showed, by immunofluorescent staining and through analysis of subcellular fractions by Western immunoblotting, that in stationary-phase promastigotes, p14 and p18 were located only in the parasite nuclei; in the middle of the log phase, a transitory and only weak expression outside the nucleus was detected. We then showed that p14 and p18 antigens shared a common epitope(s). Finally, we analyzed the in vitro proliferation and interleukin-2 production induced by leishmanial proteins in human peripheral blood mononuclear cells from sensitized subjects. We showed that in some individuals who have been exposed to L. infantum the specific response to the whole lysate was mostly due to the nuclear antigens. We demonstrated directly the capacity of nitrocellulose-bound p14 and p18 to activate in vitro all of the tested primed peripheral blood mononuclear cells, which contrasted with a lack of stimulatory activity of other membrane-bound leishmanial proteins. Taken together, our results suggest that an antigenic determinant(s) dominant for some individuals might exist on both antigens.
Parental familial vulnerability, family environment, and their interactions as predictors of depressive symptoms in adolescents.

OBJECTIVE Familial risk for depression results from both biological and social influences. These may also be associated with other characteristics, including alcohol use, smoking, and body mass index (BMI), and with environmental risks such as social problems, life events, and educational level, all of which may be associated with depression in offspring. The authors examined the links between (1) parental familial vulnerability to depression and (2) the role of associated parental characteristics on severe adolescent depressive symptoms. Third, the authors explored the influence of family environment variables. Fourth, the authors sought interactions between parental familial vulnerability and family environment. METHOD Questionnaires were obtained from 1,294 parents of 1,818 adolescent offspring. RESULTS The odds of severe adolescent depressive symptoms increased by a factor of 1.5 per standard deviation increase in parental familial vulnerability to depression (odds ratio [OR] = 1.50). Parental BMI (OR = 1.05) and educational level (OR = 2.60) had significant influences independent of parental vulnerability. Analyses indicated a significant interaction such that those with high parental familial vulnerability, whose parents also had no qualifications, had a threefold risk of severe depressive symptoms. CONCLUSIONS Adolescents with a family history of depression whose parents also lack qualifications may be a target for intervention.
Simulation of enhanced frequency response by battery storage systems: The UK versus the continental europe system

Nowadays, the large exploitation of Non-Programmable Renewable Energy Source (NPRES) generation for demand fulfillment reduces the operating hours of relevant conventional power plants, which traditionally provide the operating reserves for frequency (and voltage) control. Thus, the power system is becoming more vulnerable, also because NPRES support to ancillary service supply is often very limited. Large and fast frequency deviations, e.g., occur more often, so the risk of instability and blackout increases. New ancillary services and new providers for them are needed. Battery Energy Storage System (BESS) technologies could be good candidates, thanks to their fast response capabilities. In this work, the provision of an Enhanced (fast) Frequency Response (EFR) by a BESS is simulated, with reference to two main European synchronous areas: the UK and the Continental Europe (CE) system. The EFR service is evaluated by using real frequency data and considering the requirements issued by the UK TSO. For the CE system, those requirements are adapted according to the CE frequency behaviour. The energy exchanges requested from and carried out by the BESS, a service performance indicator, and the possible aging related to battery cycling are evaluated.
Suppression of Afterglow in CsI(Tl) by Codoping With ${\rm Eu}^{2+}$: Fabrication of Microcolumnar Films for High-Resolution High-Speed Imaging

Although CsI:Tl is one of the brightest and most efficient scintillator materials ever developed, its applicability for high-speed imaging is limited by its persistent afterglow. We have demonstrated that much of this afterglow can be suppressed by the addition of Eu2+ to the CsI host lattice. The magnitude of the effect depends strongly on the duration of the excitation pulse, but is virtually independent of its intensity. Our observations indicate that the presence of Eu2+ ions introduces a set of electron traps that fundamentally alter the decay kinetics, making the material useful for such applications as high-speed radiography and, perhaps, X-ray CT. At RMD several single crystals of CsI:Tl,Eu with Eu2+ concentrations between 0.05 to 0.5 mole percent have been grown using the Bridgman technique. Here we report on our fabrication of microcolumnar films of the material using thermal vapor deposition for high-resolution digital radiography applications. Our data suggests that the afterglow suppression effect has a profound impact on high speed imaging performance, allowing rapid data acquisition with substantially reduced persistence from previous frames. The latest results on the effect of the codopant on the luminescence from CsI:Tl crystals as well as microcolumnar films will be reported.
Changes in Residents’ Self-Efficacy Beliefs in a Clinically Rich Graduate Teacher Education Program

ABSTRACT Increasing the clinical preparation of teachers in the United States to meet greater rigor in K-12 education has become a goal of institutions of higher education, especially since the publication of the National Council for the Accreditation of Teacher Education Blue Ribbon Panel Report on Clinical Practice. Using a theoretical framework grounded in teacher self-efficacy, this article documents changes in perceptions of effectiveness in a cohort of preservice teachers over the course of a year-long clinically rich graduate-level residency program. Using the categories of the rubric that were being utilized for classroom observations, we surveyed residents about their perceptions of their own effectiveness in these areas prior to and at the conclusion of the residency program.
Effects of mood and emotion on juror processing and judgments.

This study explored the influence of mood and emotion on mock-jurors' processing of testimonial inconsistencies, perceptions of witness credibility and offender culpability, and verdicts. Jurors' mood and testimonial consistency were manipulated using a simulated trial with a 2 (mood: sad/neutral) x 2 (testimonial consistency: consistent/inconsistent) between-groups design. Sad mood resulted in more accurate reporting of testimonial inconsistencies, a finding consistent with previous research indicating more substantive processing in association with sad mood. Direct relationships between veridicality and number of inconsistencies detected and mock-juror judgments were also observed. Although anger was not experimentally manipulated, the data suggest that trial circumstances which arouse anger in jurors may impair processing and also bias their judgments of witnesses and defendants. Possible directions for research on mood and emotion in the courtroom context are suggested.
Cranial neural crest cells on the move: Their roles in craniofacial development

The craniofacial region is assembled through the active migration of cells and the rearrangement and sculpting of facial prominences and pharyngeal arches, which consequently make it particularly susceptible to a large number of birth defects. Genetic, molecular, and cellular processes must be temporally and spatially regulated to culminate in the three‐dimension structures of the face. The starting constituent for the majority of skeletal and connective tissues in the face is a pluripotent population of cells, the cranial neural crest cells (NCCs). In this review we discuss the newest scientific findings in the development of the craniofacial complex as related to NCCs. Furthermore, we present recent findings on NCC diseases called neurocristopathies and, in doing so, provide clinicians with new tools for understanding a growing number of craniofacial genetic disorders. © 2010 Wiley‐Liss, Inc.
Inlining semantics for subroutines which are recursive

Many modern programming languages offer a facility for "inlining" designated procedure and function calls, but this process is not well defined in most language standards documents. We offer a model for inlining which has the property that the resulting code does not depend upon the presentation of the order of function definitions, and which also provides a finite and consistent interpretation for the inlining of mutually recursive functions. Finally, when used on "tail-recursive" functions, our model of inlining provides for the equivalent of "loop unrolling".
Reliability of Single-leg and Double-leg Balance Tests in Subjects with Anterior Cruciate Ligament Reconstruction and Controls

The purpose of this study was to assess the test–retest reliability of postural balance in patients with anterior cruciate ligament reconstruction (ACL) and controls. Ten healthy subjects and 15 individuals with ACL reconstruction performed single-leg and double-leg balance tests. The center of pressure (COP) was recorded using a pressure platform. For the total COP path, the intraclass correlation coefficient (ICC) ranged from 0.79 to 0.91. For the COP standard deviation, the ICCs ranged from 0.68 to 0.94. For the COP velocity, the ICCs ranged from 0.72 to 0.91. The sway area and ellipse scores displayed ICCs values of 0.67 to 0.95 and 0.53 to 0.92, respectively. The ICCs were higher for double leg tests compared with single-stance ones. These results indicate that 30 s balance tests in double and single-leg stance are reliable tools to assess static balance. The use of such tests to monitor rehabilitation programs following ACL reconstruction is recommended.
Practical Minimum Cut Algorithms

The minimum cut problem for an undirected edge-weighted graph asks us to divide its set of nodes into two blocks while minimizing the weight sum of the cut edges. Here, we introduce a linear-time algorithm to compute near-minimum cuts. Our algorithm is based on cluster contraction using label propagation and Padberg and Rinaldi’s contraction heuristics [SIAM Review, 1991]. We give both sequential and shared-memory parallel implementations of our algorithm. Extensive experiments on both real-world and generated instances show that our algorithm finds the optimal cut on nearly all instances significantly faster than other state-of-the-art exact algorithms, and our error rate is lower than that of other heuristic algorithms. In addition, our parallel algorithm runs a factor 7.5× faster on average when using 32 threads. To further speed up computations, we also give a version of our algorithm that performs random edge contractions as preprocessing. This version achieves a lower running time and better parallel scalability at the expense of a higher error rate.