Miracle-dz/UniFAR-FTUs huggingface dataset:
Creative Persuasion: A Study on Adversarial Behaviors and Strategies in Phishing Attacks

Success of phishing attacks depend on effective exploitation of human weaknesses. This research explores a largely ignored, but crucial aspect of phishing: the adversarial behavior. We aim at understanding human behaviors and strategies that adversaries use, and how these may determine the end-user response to phishing emails. We accomplish this through a novel experiment paradigm involving two phases. In the adversarial phase, 105 participants played the role of a phishing adversary who were incentivized to produce multiple phishing emails that would evade detection and persuade end-users to respond. In the end-user phase, 340 participants performed an email management task, where they examined and classified phishing emails generated by participants in phase-one along with benign emails. Participants in the adversary role, self-reported the strategies they employed in each email they created, and responded to a test of individual creativity. Data from both phases of the study was combined and analyzed, to measure the effect of adversarial behaviors on end-user response to phishing emails. We found that participants who persistently used specific attack strategies (e.g., sending notifications, use of authoritative tone, or expressing shared interest) in all their attempts were overall more successful, compared to others who explored different strategies in each attempt. We also found that strategies largely determined whether an end-user was more likely to respond to an email immediately, or delete it. Individual creativity was not a reliable predictor of adversarial performance, but it was a predictor of an adversary's ability to evade detection. In summary, the phishing example provided initially, the strategies used, and the participants' persistence with some of the strategies led to higher performance in persuading end-users to respond to phishing emails. These insights may be used to inform tools and training procedures to detect phishing strategies in emails.
Incidental lung cancers and positive computed tomography images in people living with HIV

Objective: Lung cancer screening with low-dose computed tomography (LDCT) of high-risk groups in the general population is recommended by several authorities. This may not be feasible in people living with HIV (PLWHIV) due to higher prevalence of nodules. We therefore assessed the prevalence of positive computed tomography (CT) images and lung cancers in PLWHIV. Design: The Copenhagen comorbidity in HIV infection (COCOMO) study is an observational, longitudinal cohort study. Single-round LDCT was performed with subsequent clinical follow-up (NCT02382822). Method: Outcomes included histology-proven lung cancer identified by LDCT and positive CT images (noncalcified nodules) in the entire cohort and in the high-risk group (>50 years of age and >30 pack-years). We also assessed the procedures and adverse events, and clinical factors associated with a positive CT image. Results: LDCT was performed in 901 patients, including 113 at high risk for lung cancer. A positive image was found in 28 (3.1% of the entire cohort and 9.7% of the high-risk group). Nine patients (all in the high-risk group) had invasive procedures undertaken with no serious adverse events. Lung cancer (stages IA, IIA, and IIIA) was diagnosed in three patients from the high-risk group (2.7%). CD4+ cell count less than 500 cells/&mgr;l and CD4+ nadir less than 200 cells/&mgr;l were each independently associated with increased odds of a positive image odds ratio 2.32 [95% confidence interval: 1.01–5.13, P = 0.04] and odds ratio 2.63 [95% confidence interval: 1.13–6.66, P = 0.03]. Conclusion: Randomized LDCT screening trials in PLWHIV are nonexistent, but these findings are comparable with screening rounds from the general population in terms of prevalence of lung cancer and positive CT images.
FACT and the Proteasome Promote Promoter Chromatin Disassembly and Transcriptional Initiation*

The packaging of the eukaryotic genome into chromatin represses gene expression by blocking access of the general transcription machinery to the underlying DNA sequences. Accordingly, eukaryotes have developed a variety of mechanisms to disrupt, alter, or disassemble nucleosomes from promoter regions and open reading frames to allow transcription to occur. Although we know that chromatin disassembly from the yeast PHO5 promoter is triggered by the Pho4 activator, the mechanism is far from clear. Here we show that the Pho4 activator can occupy its nucleosome-bound DNA binding site within the PHO5 promoter. In contrast to the role of Saccharomyces cerevisiae FACT (facilitates chromatin transcription) complex in assembling chromatin within open reading frames, we find that FACT is involved in the disassembly of histones H2A/H2B from the PHO5 promoter during transcriptional induction. We have also discovered that the proteasome is required for efficient chromatin disassembly and transcriptional induction from the PHO5 promoter. Mutants of the degradation function of the proteasome have a defect in recruitment of the Pho4 activator, whereas mutants of the ATPase cap of the proteasome do recruit Pho4 but are still delayed for chromatin assembly. Finally, we rule out the possibility that the proteasome or ATPase cap is driving chromatin disassembly via a potential ATP-dependent chromatin remodeling activity.
A New Form of Artificial Skin to Promote Permanent Wound Coverage: A Preliminary Report

Background Although tendon-exposed or bone-exposed wounds can be resurfaced with flaps, such surgeries may not be feasible in patients with poor general or local conditions. Biosynthetic artificial skin is an alternative for critical wound coverage. We designed a new artificial skin bilayer to close difficult wounds permanently. Aim and Objectives This study compares incorporation and wound contraction between silicone acellular porcine dermis (SAPD) and the Integra graft (Integra Life Sciences Corp., Billerica, Mass) in a rat model. Materials and Methods The SAPD was manufactured according to our previously described standard procedures. Integra grafts were obtained commercially. We included 24 male adult Sprague-Dawley rats and divided them into 2 groups. After creating a 3 × 4-cm full-thickness wound on the back, we transplanted the same-sized SAPD and Integra grafts onto the rat wounds. Autologous full-thickness skin (FTS) was grafted onto the acellular porcine dermal matrix (APDM) of the SAPD and the Integra dermal matrix (IDM) 2 weeks later. We measured the wound size and contraction rate of recipient wounds, studied the incorporation of FTS on the dermal matrix, and did pathological examination. Generalized estimating equations were used to assess the data from repeated wound and scar contraction measurements using SAS v9.2. Results The sizes of wounds of both groups decreased over time. No difference in wound contraction was observed between the SAPD and Integra groups at weeks 2, 4, or 6 after grafting. However, the contraction rates in both groups increased significantly. The pathological examination showed that the FTS was well incorporated in the APDM and IDM. The recipient wounds showed new vessels and cell infiltration in the new matrix, but no severe inflammation. Skin appendages were regenerating in the FTS. There was no rejection sign. Conclusions Both SAPD and Integra are double-layered artificial skin products. Our results demonstrate that APDM and IDM are good templates and show excellent incorporation with autologous FTS graft. The results also demonstrated gradual wound contraction over time, but the contraction rate was not different between SAPD and Integra 6 weeks after grafting in a rat model.
Notch signaling is necessary for epithelial growth arrest by TGF-β

Transforming growth factor β (TGF-β) and Notch act as tumor suppressors by inhibiting epithelial cell proliferation. TGF-β additionally promotes tumor invasiveness and metastasis, whereas Notch supports oncogenic growth. We demonstrate that TGF-β and ectopic Notch1 receptor cooperatively arrest epithelial growth, whereas endogenous Notch signaling was found to be required for TGF-β to elicit cytostasis. Transcriptomic analysis after blocking endogenous Notch signaling uncovered several genes, including Notch pathway components and cell cycle and apoptosis factors, whose regulation by TGF-β requires an active Notch pathway. A prominent gene coregulated by the two pathways is the cell cycle inhibitor p21. Both transcriptional induction of the Notch ligand Jagged1 by TGF-β and endogenous levels of the Notch effector CSL contribute to p21 induction and epithelial cytostasis. Cooperative inhibition of cell proliferation by TGF-β and Notch is lost in human mammary cells in which the p21 gene has been knocked out. We establish an intimate involvement of Notch signaling in the epithelial cytostatic response to TGF-β.
Effect of nanodimensional polyethylenimine layer on surface potential barriers of hybrid structures based on silicon single crystal

In this report we present the analysis of I-V curves for MIS-structures like silicon substrate / nanodimensional polyelectrolyte layer / metal probe (contact) which is promising for biosensors, microfluidic chips, different devices of molecular electronics, such as OLEDs, solar cells, where polyelectrolyte layers can be used to modify semiconductor surface. The research is directed to investigate the contact phenomena which influence the resulting signal of devices mentioned above. The comparison of I-V characteristics of such structures measured by scanning tunnel microscopy (contactless technique) and using contact areas deposited by thermal evaporation onto the organic layer (the contact one) was carried out. The photoassisted I-V measurements and complex analysis based on Simmons and Schottky models allow one to extract the potential barriers and to observe the changes of charge transport in MIS-structures under illumination and after polyelectrolyte adsorption. The direct correlation between the thickness of the deposited polyelectrolyte layer and both equilibrium tunnel barrier and Schottky barrier height was observed for hybrid structures with polyethylenimine. The possibility of control over the I-V curves of hybrid structure and the height of the potential barriers (for different charge transports) by illumination was confirmed. Based on experimental data and complex analysis the band diagrams were plotted which illustrate the changes of potential barriers for MIS-structures due to the polyelectrolyte adsorption and under the illumination.
Network and Individual Factors Associated with Drug Use among Female Sex Workers (FSWs) in Southern China: A Mixed-Method Approach

ABSTRACT Research on women who engage both in drug use and sex work has been limited, as most previous studies have focused on these risk behaviors separately. The current study examines the network properties as well as the demographic and behavioral factors associated with drug use among female sex workers (FSWs) in southern China. We collected survey data (n = 175) in the Hainan province during our 26 months of ethnographic fieldwork in China. Our analyses included Fisher's exact chi-square tests, independent-samples t-tests, Mann-Whitney U, binary logistic regression (LR), as well as ethnographic data analysis. Multivariate analysis showed that women who were younger age, single, more educated, and earning a higher income were more likely to use drugs. Pertaining to network properties, FSWs with a lower percentage of long-term clients (and men) in ego networks were more likely to use drugs; this would imply a mechanism by which drug-using FSWs are more at risk, as the women take a greater number of transient clients. In addition, FSWs who were influential network members (i.e., higher betweenness centrality) and were closely related to other network members (i.e., higher closeness centrality) were more likely to use drugs; this may suggest that drug use is a means of sustaining the high functionality of the workers. Our ethnographic data also showed that club drug use was easily accessible in entertainment venues and was often a means of socialization in FSW communities. Network characteristics correlated to HIV-related risks among FSWs should be further examined in future studies.
Optical Characterization of OLED Emitter Properties by Radiation Pattern Analyses

Researches in both, academia and industry are investigating optical loss channels in OLED layered systems by means of optical simulation tools in order to derive promising concepts for a further enhancement of the overall device performance. Besides other factors, the prospects of success of such optimization strategies rely severely on the credibility of the optical input data. The present thesis provides a guideline to measure the active optical properties of OLED emitter materials in situ by radiation pattern analyses. Reliable and widely applicable methods are introduced to determine the internal electroluminescence spectrum, the profile of the emission zone, the dipole emitter orientation, and the internal luminescence quantum efficiency of emissive materials from the optical far field emission of OLEDs in electrical operation. The proposed characterization procedures are applied to sets of OLEDs containing both, fluorescent polymeric materials as well as phosphorescent small-molecular emitters, respectively. On the one hand, quite expected results are obtained. On the other hand, several novel and truly surprising results are found. Most importantly, this thesis contains the first report of a non-isotropic, mainly parallel emitter orientation in a phosphorescent small-molecular guest-host system (Ir(MDQ)2(acac) in a-NPD). Due to the latter result, emitter orientation based optimization of phosphorescent OLEDs seems to be within reach. Since parallel dipoles emit preferably into air, the utilization of smart emissive materials with advantageous molecular orientation is capable to boost the efficiency of phosphorescent OLEDs by 50%. Materials design, the influence of the matrix material and the substrate, as well as film deposition conditions are just a few parameters that need to be studied further in order to exploit the huge potential of the dipole emitter orientation in phosphorescent OLEDs.
Multimodal imaging biomarkers in premanifest and early Huntington's disease: 30-month IMAGE-HD data

Background The discovery of potential disease-modifying therapies in a neurodegenerative condition like Huntington's disease depends on the availability of sensitive biomarkers that reflect decline across disease stages and that are functionally and clinically relevant. Aims To quantify macrostructural and microstructural changes in participants with premanifest and symptomatic Huntington's disease over 30 months, and to establish their functional and clinical relevance. Method Multimodal magnetic resonance imaging study measuring changes in macrostructural (volume) and microstructural (diffusivity) measures in 40 patients with premanifest Huntington's disease, 36 patients with symptomatic Huntington's disease and 36 healthy control participants over three testing sessions spanning 30 months. Results Relative to controls, there was greater longitudinal atrophy in participants with symptomatic Huntington's disease in whole brain, grey matter, caudate and putamen, as well as increased caudate fractional anisotropy; caudate volume loss was the only measure to differ between premanifest Huntington's disease and control groups. Changes in caudate volume and fractional anisotropy correlated with each other and neurocognitive decline; caudate volume loss also correlated with clinical and disease severity. Conclusions Caudate neurodegeneration, especially atrophy, may be the most suitable candidate surrogate biomarker for consideration in the development of upcoming clinical trials.
MobiCoRE: Mobile Device Based Cloudlet Resource Enhancement for Optimal Task Response

Cloudlets are small self maintained clouds, with hotspot like deployment, to enhance the computational capabilities of the mobile devices. The limited resources of cloudlets can become heavily loaded during peak utilization. Consequently, per user available computational capacity decreases and at times mobile devices find no execution time benefit for using the cloudlet. Researchers have proposed augmenting the cloudlet resources using mobile devices; however, the proposed approaches do not consider the offered service to load ratio while using mobile device resources. In this paper, we propose easy to implement Mobile Device based Cloudlet Resource Enhancement (MobiCoRE) while ensuring that: (i) mobile device always have time benefit for its tasks submitted to the cloudlet and (ii) cloudlet induced mobile device load is a fraction of its own service requirement from the cloudlet. We map MobiCoRE on M/M/c/K queue and model the system using birth death markov chain. Given the arrival rate of <inline-formula> <tex-math notation="LaTeX">$\lambda$</tex-math><alternatives> <inline-graphic xlink:href="whaiduzzaman-ieq1-2564407.gif"/></alternatives></inline-formula>, <inline-formula> <tex-math notation="LaTeX">$c$</tex-math><alternatives><inline-graphic xlink:href="whaiduzzaman-ieq2-2564407.gif"/> </alternatives></inline-formula> cpu cores in cloudlet, maximum tasks in the cloudlet to be <inline-formula> <tex-math notation="LaTeX">$K$</tex-math><alternatives><inline-graphic xlink:href="whaiduzzaman-ieq3-2564407.gif"/> </alternatives></inline-formula> and <inline-formula><tex-math notation="LaTeX">$P_0=f(\lambda, c,K,\mu)$</tex-math> <alternatives><inline-graphic xlink:href="whaiduzzaman-ieq4-2564407.gif"/></alternatives></inline-formula> be probability of having no user in cloudlet, we derive the condition <inline-formula><tex-math notation="LaTeX"> $\frac{1}{P_0}= \frac{\lambda ^K}{c^{K-c}c! \mu ^K}1000$</tex-math><alternatives> <inline-graphic xlink:href="whaiduzzaman-ieq5-2564407.gif"/></alternatives></inline-formula> for optimal average service time <inline-formula><tex-math notation="LaTeX">$\frac{1}{\mu}$</tex-math><alternatives> <inline-graphic xlink:href="whaiduzzaman-ieq6-2564407.gif"/></alternatives></inline-formula> of cloudlet such that the mobile applications have maximum benefit for using cloudlet services. We show that the optimal average service time is independent of the applications service requirement. Evaluation shows that MobiCoRE can accommodate upto 50 percent extra users when operating at optimal service time and sharing mobile resources for remaining task, compared to completing the entire user applications in cloudlet. Similarly, up to 47 percent time benefit can be achieved for mobile devices by sharing only 16 percent computational resources with the cloudlet.
Depression is Closely Associated With Chronic Low Back Pain in Patients Over 50 Years of Age: A Cross-sectional Study Using the Sixth Korea National Health and Nutrition Examination Survey (KNHANES VI-2)

Study Design. A cross-sectional study. Objective. This study was designed to analyze the relationship between the presence and severity of depression and low back pain (LBP) in a representative sample of the general population using a self-report screening questionnaire for depression. Summary of Background Data. There is increasing evidence supporting an association between depression and LBP. However, the degree of the association between these two conditions in the general population is poorly understood. Methods. Health surveys and examinations were conducted on a nationally representative sample (n = 7550) of Koreans. LBP status was determined by a simple survey response concerning LBP >30 days during the past 3 months. Depression was defined as individuals with a total score >10 on the Patient Health Questionnaire (PHQ)-9 survey. The severity of depression was categorized as none (0–4), mild (5–9), moderate (10–14), moderately severe (15–19), and severe (20–27) according to PHQ-9 score. Data regarding demographics, socioeconomic history, and comorbid health conditions were used to analyze adjusted, weighted logistic regression models. Results. In the Korean population, the prevalence of depression was significantly greater in individuals with LBP (20.3%) than in those without LBP (4.5%). On multivariate logistic regression analysis, the presence of depression was significantly associated with LBP (adjusted odd ratio [aOR]: 3.93, P < 0.001). The risk of LBP increased with increasing severity of depression as follows: severe depression (aOR: 9.28, P < 0.001), moderately severe depression (aOR: 3.24, P = 0.001), moderate depression (aOR: 4.97, P < 0.001), and mild depression (aOR: 2.48, P < 0.001). Conclusion. Depression is more common in patients with LBP among Koreans. The presence of depression was significantly associated with LBP, especially in severely depressed individuals. Level of Evidence: 3
3 × 104 Gb/s Single-λ Interconnect of Mode-Division Multiplexed Network With a Multicore Fiber

In this paper, we study the use of silicon microring modulators in an integrated mode-division multiplexing (MDM) network for short-reach interconnects using discrete multitone (DMT) modulation. A fiber grating coupler array is used as a high-speed optical interface between the on-chip mode channels and off-chip multicore fiber (MCF). The whole link has a crosstalk level lower than –23.1 dB. The MDM network can work without the crosstalk compensation of digital signal processing. We present experimental results of the linearity of the silicon microring modulator in terms of spurious-free dynamic range (SFDR). The third-order intermodulation distortion SFDR is 93.4 dB/Hz 2/3 at 20 GHz. We can improve system performance by using adaptive nonlinear equalizer at the DMT receiver to mitigate transmitter and transmission impairments. An aggregate bitrate above 312 Gb/s is achieved with a bit error ratio of 3.8 × 10−3. With the addition of nonlinear equalizer, the line rates of the MDM network can be further increased to about 330 Gb/s. The experimental results demonstrate the feasibility of single wavelength DMT transmission in MDM network with MCF.
Correlation Funktions of a System with Different Temperatures of the Particle Components

We consider a plasma consisting of particle components with different temperatures. The components are uniformly distributed in the configuration space and MAXWELLIAN in the velocity space. Pair correlations are assumed to be small and higher order correlations negligible. It is shown from the BBGKY-hierarchy that the influence of the electrons on the ion kinetics can be taken into account by treating the ions as dressed particles. The hierarchy for these dressed particles provides the ion-ion correlation function. The electron-ion pair correlation is calculated from the POISSON equation using the ion-ion correlation and relating the electron-ion pair distribution to the average potential. By the same procedure we derive the electron-electron correlation making use of the electron-ion correlation. The results are compared with those of other authors.