Miracle-dz/UniFAR-FTUs huggingface dataset:
An α2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas

The MUC1 mucin is expressed on the luminal surface of most simple epithelial cells but in carcinomas, especially those of the breast and ovary, MUC1 is upregulated and aberrantly glycosylated. MUC1 contains a large amount of O-linked glycans which, in the mucin expressed by normal mammary epithelial cells, consist mainly of core 2 based structures carrying polylactosamine chains. However, the mucin expressed by breast carcinomas has shorter side-chains, often consisting of sialylated core 1 (Galbeta1-3GalNAc). in situ hybridization of primary breast tissue showed that a sialyltransferase (ST3Gal I), responsible for adding sialic acid to core 1 thereby terminating chain extension, is elevated in primary breast carcinomas when compared to normal or benign tissue. Furthermore, the level of mRNA expression encoding ST3Gal I is correlated to the intensity of staining seen with the antibody SM3, which specifically recognises underglycosylated, tumour associated MUC1. Thus, the aberrant glycosylation of MUC1 seen in breast carcinomas appears to be due, at least in part, to the elevation of ST3Gal I.
Come and Be Served: Parallel Decoding for COTS RFID Tags

Current commodity RFID systems incur high communication overhead due to severe tag-to-tag collisions. Although some recent works have been proposed to support parallel decoding for concurrent tag transmissions, they require accurate channel measurements, tight tag synchronization, or modifications to standard RFID tag operations. In this paper, we present BiGroup, a novel RFID communication paradigm that allows the reader to decode the collision from multiple commodity-off-the-shelf (COTS) RFID tags in one communication round. In BiGroup, COTS tags can directly join ongoing communication sessions and get decoded in parallel. The collision resolution intelligence is solely put at the reader side. To this end, BiGroup examines the tag collisions at RFID physical layer from constellation domain as well as time domain, exploits the under-utilized channel capacity due to low tag transmission rate, and leverages tag diversities. We implement BiGroup with USRP N210 software radio that is able to read and decode multiple concurrent transmissions from COTS passive tags. Our experimental study gives encouraging results that BiGroup greatly improves RFID communication efficiency, i.e., 11 times performance improvement compared with the alternative decoding scheme for COTS tags.
Formal development of secure email

Developing systems that are assured to be secure requires precise and accurate descriptions of specifications, designs, implementations, and security properties. Formal specification and verification have long been recognized as giving the highest degree of assurance. In this paper, we describe a software development process that integrates formal verification and synthesis. We demonstrate this process by developing assured sender and receiver C++ code for a secure electronic mail system, Privacy Enhanced Mail. We use higher-order logic for system-requirements specification, design specifications and design verification. We use a combination of higher-order logic and category theory and tools supporting these formalism to refine specifications and synthesize code. Much of our work is applicable to other secure email protocols, as our development is parameter used, component-based, and reusable.
Memory lost, memory regained: neuropsychological findings and neuroimaging in two cases of paraneoplastic limbic encephalitis with radically different outcomes

OBJECTIVE To report two cases of paraneoplastic limbic encephalitis (PNLE) with similar clinical presentation, but dramatically different outcome and to highlight the role of neuropsychological and radiological evaluation in PNLE. METHODS Both patients underwent an extensive battery of neuropsychological tests designed to document general intellectual function, anterograde verbal and visual memory, naming, knowledge and executive ability. In addition, structural (CT and MRI) and functional (HMPAO-SPECT) brain scans were performed. RESULTS Both patients presented with fairly sudden onset of profound and persistent memory loss in the absence of other neurological symptoms. Their subsequently diagnosed small cell lung cancer was treated with a combination of radiotherapy and chemotherapy, leading to remission of the tumour. The memory of patient 1 recovered fully and he died from an unrelated cause 1 year later; neuropsychological testing showed a severe, but isolated, anterograde amnesia, brain MRI was normal and HMPAO-SPECT showed left medial temporal hypoperfusion. Patient 2 remained densely amnesic despite regression of her lung tumour; neuropsychological testing disclosed both anterograde and extensive retrograde amnesia together with more generalised cognitive deficits including anomia and executive impairments, MRI showed gross atrophy of the hippocampus and amygdala bilaterally, and HMPAO-SPECT showed pronounced frontal and temporal hypoperfusion. CONCLUSION Complete remission from PNLE may occur and seems to be associated with pure anterograde amnesia without evidence of structural hippocampal damage in MRI. By contrast, cognitive deficits beyond severe anterograde amnesia and evidence of destructive medial temporal lobe pathology on MRI seem to be poor prognostic features.
Reduction of Diabetes-Induced Oxidative Stress, Fibrotic Cytokine Expression, and Renal Dysfunction in Protein Kinase Cβ–Null Mice

Diabetes induces the activation of several protein kinase C (PKC) isoforms in the renal glomeruli. We used PKC-β−/− mice to examine the action of PKC-β isoforms in diabetes-induced oxidative stress and renal injury at 8 and 24 weeks of disease. Diabetes increased PKC activity in renal cortex of wild-type mice and was significantly reduced (<50% of wild-type) in diabetic PKC-β−/− mice. In wild-type mice, diabetes increased the translocation of PKC-α and -β1 to the membrane, whereas only PKC-α was elevated in PKC-β−/− mice. Increases in urinary isoprostane and 8-hydroxydeoxyguanosine, parameters of oxidative stress, in diabetic PKC-β−/− mice were significantly reduced compared with diabetic wild-type mice. Diabetes increased NADPH oxidase activity and the expressions of p47phox, Nox2, and Nox4 mRNA levels in the renal cortex and were unchanged in diabetic PKC-β−/− mice. Increased expression of endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β, connective tissue growth factor (CTGF), and collagens IV and VI found in diabetic wild-type mice was attenuated in diabetic PKC-β−/− mice. Diabetic PKC-β−/− mice were protected from renal hypertrophy, glomerular enlargement, and hyperfiltration observed in diabetic wild-type mice and had less proteinuria. Lack of PKC-β can protect against diabetes-induced renal dysfunction, fibrosis, and increased expressions of Nox2 and -4, ET-1, VEGF, TGF-β, CTGF, and oxidant production.
Optical Injection and Lasing Dynamics in Long-Wavelength VCSELs With Intracavity Patterning

We present the static and optical injection response of wafer-fused long-wavelength VCSELs with and without intracavity patterning. It is found that the extra optical cavity patterning increases the gain anisotropy between orthogonal polarization modes, increasing the polarization stability, and influencing the dynamic response of the device. Dynamics features are summarized on maps in the injection power-master/slave detuning plane, and good agreement is obtained with the spin-flip model of VCSEL polarization modes.
The relationship between basic need satisfaction and emotional eating in obesity

Abstract Emotional eating has been identified as a factor that promotes the development and maintenance of obesity and hinders its treatment. This study investigated the relationship between unsatisfied basic needs and emotional eating, including the mediating factors of self‐esteem and coping strategies. The results from a survey of 136 obese individuals indicated support for a significant relationship between basic need satisfaction and emotional eating, with a mediating effect of negative coping strategies. These findings extend previous research and provide guidance on how to help individuals who engage in emotional eating by focusing on developing more adaptive coping strategies.
Influence of Three Types of Automated Coagulometers on the International Sensitivity Index (ISI) of Rabbit, Human, and Recombinant Human Tissue Factor Preparations

Summary Five tissue factor reagents and three types of automated instruments for prothrombin time (PT) determination were studied in an international multicenter collaborative exercise. The purpose of this work was to determine the international sensitivity index (ISI) for each combination of reagent and instrument against the international reference preparation RBT/90. Each type of instrument was used by 3 or 4 centers to assess the interlaboratory variation of the ISI. The interlaboratory variation of the ISI for each combination of reagent and instrument ranged between 0.4% and 7.8% coefficient of variation. For three reagents, the mean ISI values for ACL (nephelometric) and STA (mechanical) were practically identical, but the mean ISI values for MLA (photo-optical) were at least 10% higher. For two other reagents prepared from rabbit tissue, the mean ISI values increased in the order ACL, STA, MLA. The widest range of mean ISI values was noted with one rabbit tissue factor reagent: 1.68 for ACL and 2.00 for MLA. Exclusion of patient specimens with INR <1.5 and INR >4.5 determined by the international reference preparation resulted in a slight decrease of the mean ISI. The interlaboratory variation of the International Normalized Ratio (INR) was assessed from the results obtained with common lyophilized and deep-frozen plasmas. The use of instrument-specific ISI values resulted in reduced interlaboratory variation of the INR. It is recommended that thromboplastin manufacturers provide instrument-specific ISI values.
Migration and regional wages.

"This paper presents a new method of using wage data in a model of U.S. interregional migration. This method makes better use of human capital theory than has been done in previous studies. By restricting the variability of real predicted individual regional wages, more satisfactory estimates of a migration model are obtained using microdata than when no restrictions are imposed. A multiple choice conditional logit model is applied to migration as a choice among the four U.S. census regions. Two U.S. microdata sets are used to estimate the model. "
Pacific Asia Conference on Information Systems ( PACIS ) 9 July 2011 Coordination Effectiveness In An Agile Software Development Context

Effective coordination is an important factor in successful software projects that has not been fully explored in the context of agile software development. Agile software development projects eschew many traditional practices for achieving coordination leaving a gap in our understanding of exactly how such projects are coordinated and if this coordination is effective. However, before investigating coordination behaviours provided in agile software development, and how effective they are, it is necessary to have an understanding of the concept of „coordination effectiveness‟. This paper defines „coordination effectiveness‟ based on existing coordination research and case study interview data drawn from experts in the field of agile and non-agile software development. From this, a definition of coordination effectiveness is developed. Such a clearly defined concept should prove useful for future research when assessing coordination behaviours in agile software development projects and for those investigating other types of project and other classes of system development methodology.
Saliva-binding protein (SsaB) from Streptococcus sanguis 12 is a lipoprotein

Two lipoprotein consensus sequences (Leu-X-X-Cys) are found in the presumptive signal peptide region (positions 12 to 15 and 17 to 20) of saliva-binding protein (SsaB) from Streptococcus sanguis 12. Three analogs of SsaB containing Cys-->Gly mutations were constructed by site-directed mutagenesis of pSA2, the recombinant plasmid expressing SsaB. [3H]palmitate was incorporated into SsaB only when the native Cys-20 residue was present. These data show that SsaB is a lipoprotein and that Cys-20 is the critical site for acylation.
Regulation of the Tumor Suppressor PTEN through Exosomes: A Diagnostic Potential for Prostate Cancer

PTEN is a potent tumor-suppressor protein. Aggressive and metastatic prostate cancer (PC) is associated with a reduction or loss of PTEN expression. PTEN reduction often occurs without gene mutations, and its downregulation is not fully understood. Herein, we show that PTEN is incorporated in the cargo of exosomes derived from cancer cells. PTEN is not detected in exosomes derived from normal, noncancerous cells. We found that PTEN can be transferred to other cells through exosomes. In cells that have a reduction or complete loss of PTEN expression, the transferred PTEN is competent to confer tumor-suppression activity to acceptor cells. In PC patients, we show that PTEN is incorporated in the cargo of exosomes that circulate in their blood. Interestingly, normal subjects have no PTEN expression in their blood exosomes. Further, we found that the prostate-specific antigen (PSA) is incorporated in PC patients’ and normal subjects’ blood exosomes. These data suggest that exosomal PTEN can compensate for PTEN loss in PTEN deficient cells, and may have diagnostic value for prostate cancer.
Participant role approach to school bullying: implications for interventions.

This paper describes practical implications of the participant role approach to bullying in schools. This view looks at bullying as a group phenomenon which is largely enabled and maintained by members of a school class taking on different participant roles (such as assistants of the bully, reinforcers of the bully, or outsiders). Since peers are involved in bullying in different ways, and seem to be powerful moderators of behaviour in a school class, this "peer group power" should also be utilized in putting an end to bullying. In interventions targeting the whole peer group it is peers that, after initial adult encouragement and training, take action against bullying. This happens informally, in their spontaneous everyday intractions. Peers can also be utilized in formal helper roles, as peer counsellors. It is suggested that the focus of counselling could be shifted from supporting the victims towards also working with students in other participant roles.
Modulation of Mitochondrial Function by Hydrogen Peroxide*

During normal cellular metabolism, mitochondrial electron transport results in the formation of superoxide anion (O⨪2) and subsequently hydrogen peroxide (H2O2). Because H2O2 increases in concentration under certain physiologic and pathophysiologic conditions and can oxidatively modify cellular components, it is critical to understand the response of mitochondria to H2O2. In the present study, treatment of isolated rat heart mitochondria with H2O2 resulted in a decline and subsequent recovery of state 3 NADH-linked respiration. Alterations in NADH levels induced by H2O2 closely paralleled changes in the rate of state 3 respiration. Assessment of electron transport chain complexes and Krebs cycle enzymes revealed that α-ketoglutarate dehydrogenase (KGDH), succinate dehydrogenase (SDH), and aconitase were susceptible to H2O2 inactivation. Of particular importance, KGDH and SDH activity returned to control levels, concurrent with the recovery of state 3 respiration. Inactivation is not because of direct interaction of H2O2 with KGDH and SDH. In addition, removal of H2O2alone is not sufficient for reactivation. Enzyme activity does not recover unless mitochondria remain intact. The sensitivity of KGDH and SDH to H2O2-mediated inactivation and the reversible nature of inactivation suggest a potential role for H2O2 in the regulation of KGDH and SDH.
Beyond performativity: reflections on activist professionalism and the labour process in further education

The paper examines the argument that the contradictions of performativity provide the context in which new forms of professionalism can develop. English further education is used to explore these questions. The paper addresses four issues. It seeks to locate the discussion within the period immediately following the incorporation of colleges of further education in 1993, when colleges of further education were removed from local authority control and placed under aegis of the Further Education Funding Council. This is followed by an examination of changes to the management regime following incorporation. It considers suggestions that bullying forms of management have been superseded and that there has been some feminization of senior management. This discussion is set alongside one addressing the socio‐economic context as well as hegemonic understandings of the economy. The final part of the paper examines claims made for the development of an ‘activist’ or transformative professionalism. However the key .
Restructuring organisations while striving for flexicurity : Connecting the European level to national contexts

This book presents a new and stimulating analysis of restructuring by developing a European perspective. Developing the capacity to anticipate change is a complex dynamic, involving the global strategies of firms, and the capacity of the actors at enterprise and territorial levels. The book provides a clear analysis of the capacity of the actors, through different models of industrial relations and corporate governance, to intervene in the process of restructuring. It identifies the conditions of anticipation and the need to better articulate European policies. The research also shows the need to adopt a multilevel and multiplayer approach in order to adapt to the new strategies of the firms. The multidisciplinary approach of the research underlines different perspectives: the political challenges of the European Union, the legal and social implications related to the employees' representatives, trade unions and European works councils, and the sociological dimension in the process of restructuring and of anticipation. The aim is to develop a multilevel and multiactor analysis and to propose guidelines for actions at European level.
MuCCRA-3: A low power dynamically Reconfigurable Processor Array

MuCCRA-3 is a low power coarse-grained Dynamically Reconfigurable Processor Array (DRPA) for a flexible off-loading engine in various SoC (System-on-a-Chip). Similar to the other DRPAs, it has an array of processing elements (PEs), a simple coarse-grained processor, consisting of an ALU and a register file, and dynamic reconfiguration of the array enables time-multiplexed execution. DRPAs including MuCCRA-3 provide multiple sets of configuration data called hardware contexts, and switch them in a clock cycle. For low power computation, the PE array structure of MuCCRA-3 is optimized according to the evaluation results of previous prototypes, MuCCRA-1 and 2[1], and was implemented with 65nm low power CMOS process from Fujitsu. By using a real chip, the power consumption and performance are evaluated. The evaluation results suggest that MuCCRA-3 works with extremely low power: 10mW–13mW.
Autopedia: automatic domain-independent Wikipedia article generation

This paper proposes a general framework, named Autopedia, to generate high-quality wikipedia articles for given concepts in any domains, by automatically selecting the best wikipedia template consisting the sub-topics to organize the article for the input concept. Experimental results on 4,526 concepts validate the effectiveness of Autopedia, and the wikipedia template selection approach which takes into account both the template quality and the semantic relatedness between the input concept and its sibling concepts, performs the best.
Banking Market Structure, Liquidity Needs, and Industrial Growth Volatility

While the existing literature acknowledges the effect of banking structure on industrial growth as well as the effect of financial development on industrial growth and its volatility, we examine whether banking structure, given bank (financial) development, exerts any nontrivial effect on industrial growth volatility. We show that bank concentration magnifies industrial growth volatility, but reduces the volatility in sectors with higher external liquidity needs. The reduction in industrial growth volatility mostly reflects the smoothing in the variance of real value added per firm growth. Finally a variety of sensitivity checks show that our findings remain for different model specifications, banking market structure measures, liquidity needs indicators, and omitted variables.
User-Sensitive Mobile Interfaces: Accounting for Individual Differences amongst the Blind

Mobile phones pervade our daily lives and play ever expanding roles in many contexts. Their ubiquitousness makes them pivotal in empowering disabled people. However, if no inclusive approaches are provided, it becomes a strong vehicle of exclusion. Even though current solutions try to compensate for the lack of sight, not all information reaches the blind user. Good spatial ability is still required to make sense of the device and its interface, as well as the need to memorize positions on screen or keys and associated actions in a keypad. Those problems are compounded by many individual attributes such as age, age of blindness onset or tactile sensitivity which often are forgotten by designers. Worse, the entire blind population is recurrently thought of as homogeneous (often stereotypically so). Thus all users face the same solutions, ignoring their specific capabilities and needs. We usually ignore this diversity as we have the ability to adapt and become experts in interfaces that were probably maladjusted to begin with. This adaptation is not always within reach. Interaction with mobile devices is highly visually demanding which widens this gap amongst blind people. It is paramount to understand the impact of individual differences and their relationship with demands to enable the deployment of more inclusive solutions. We explore individual differences among blind people and assess how they are related with mobile interface demands, both at low (e.g. performing an on-screen gesture) and high level (text-entry) tasks. Results confirmed that different ability levels have significant impact on the performance attained by a blind person. Particularly, otherwise ignored attributes like tactile acuity, pressure sensitivity, spatial ability or verbal IQ have shown to be matched with specific mobile demands and parametrizations.
The Link between Parental and Offspring Longevity

Studies of adult mortality typically examine the impact of individual characteristics, but ignore the fact that the characteristics of people closely linked to those individuals also influence mortality risk. This paper examines the effect of parental longevity on survival outcomes of adult offspring using survey data from the University of Michigan Health and Retirement Study (HRS) between 1992 and 2008. It employs a competing risk model that controls for correlation between individual death and survey non-response. There is strong evidence that individuals with longer-lived parents exhibit lower mortality risk. Even after controlling for health conditions and behavioral variables of the offspring, parental age at death has a substantial impact on the survival of the adult offspring, suggesting a strong genetic component that must be considered as important in determining longevity.