Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti-CD79 Antibody Induces B Cell Anergy That Protects against Autoimmunity

B cells play a major role in the pathogenesis of many autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and type I diabetes mellitus, as indicated by the efficacy of B cell–targeted therapies in these diseases. Therapeutic effects of the most commonly used B cell–targeted therapy, anti-CD20 mAb, are contingent upon long-term depletion of peripheral B cells. In this article, we describe an alternative approach involving the targeting of CD79, the transducer subunit of the B cell AgR. Unlike anti-CD20 mAbs, the protective effects of CD79-targeted mAbs do not require cell depletion; rather, they act by inducing an anergic-like state. Thus, we describe a novel B cell–targeted approach predicated on the induction of B cell anergy.
Detection of feline coronavirus in cerebrospinal fluid for diagnosis of feline infectious peritonitis in cats with and without neurological signs

Objectives The objective of this study was to evaluate the sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction (real-time RT-PCR) detecting feline coronavirus (FCoV) RNA in cerebrospinal fluid (CSF) of cats with and without neurological and/or ocular signs for the diagnosis of feline infectious peritonitis (FIP). Methods This prospective case-control study included 34 cats. Nineteen cats had a definitive histopathological diagnosis of FIP (seven of these with neurological and/or ocular signs), and 15 cats had other diseases but similar clinical signs (three of these with neurological and/or ocular signs). Real-time RT-PCR was performed on the CSF of all cats, and sensitivity, specificity, and positive (PPV) and negative predictive values (NPV) were calculated. Results Real-time RT-PCR of CSF showed a specificity of 100% in diagnosing FIP, a sensitivity of 42.1%, a PPV of 100% and an NPV of 57.7%. The sensitivity of the real-time RT-PCR of CSF in cats with neurological and/or ocular signs was 85.7%. Conclusions and relevance Although it is known that RT-PCR can give false positive results, especially if performed using serum or plasma, this real-time RT-PCR detecting FCoV RNA in CSF can be considered a reliable specific tool for the diagnosis of FIP. If only cats with neurological involvement are evaluated, the sensitivity of this real-time RT-PCR in CSF is also high.
Second Harmonic Filtering in Phasor Measurement Estimation

In this letter, the application of two different techniques for improved second harmonic filtering observed in single-phase phasor measurements, under offnominal frequency operation, is presented. The main advantage of the proposed methods is that it can be readily incorporated into the existing uniform sampling and fixed window length phasor measurement computation framework. The two approaches are compared against the three-point-average filter, showing improved performance.
Time interval digitization with an integrated 32-phase oscillator

A time measurement circuit based on the principle of the multiple-phase oscillator is presented. The multiple phases are realized with a delay line ring oscillator, resulting in a compact, simple structure. The circuit is implemented in 5 V, 1.2 um CMOS process. The measured single-shot resolution is 1.5 ns (sigma-value) and the maximum measured error is 4 ns in the measurement range 5 ns -10 us with temperature variation between -40 to +60/spl deg/C and supply voltage variation between 4.5 and 5.5 V. Nominal current consumption is 2.5 mA. <<ETX>>
LYS2 gene and its mutation in Kluyveromyces lactis

The KlLYS2 gene, encoding the α‐aminoadipate reductase of Kluyveromyces lactis, was isolated by complementation of a lysA1 mutant. The deduced amino acid sequence shared an identity of 73% with the LYS2 product of Saccharomyces cerevisiae. Despite the high sequence homology of the α‐aminoadipate reductase genes, the two yeast species differently responded to the presence of α‐aminoadipate in the medium. Wild‐type S. cerevisiae is known to be sensitive to α‐aminoadipate, but becomes resistant when mutated to lys2. In contrast, K. lactis strains were found to be naturally resistant to α‐aminoadipate. Therefore, the positive selection procedure for the isolation of lys2 mutants on α‐aminoadipate, as practised in S. cerevisiae, cannot be applied to K. lactis. A possible reason of this difference may be that the catalytic rate of the α‐aminoadipate reductase differs in the two yeasts. The EMBL/Genbank Accession No. for the KlLYS2 gene is AJ504405. Copyright © 2003 John Wiley & Sons, Ltd.
IS 1 R-Mediated Plasticity of IncL / M Plasmids Leads to the Insertion of bla OXA-48 into the Escherichia coli Chromosome

R. Beyrouthy, F. Robin, J. Delmas, L. Gibold, G. Dalmasso, F. Dabboussi, M. Hamzé, R. Bonnet Clermont Université, UMR 1071 INSERM/Université d’Auvergne, Clermont-Ferrand, France; INRA, USC 2018, Clermont-Ferrand, France; Health and Environment Microbiology Laboratory, AZM Research Centre of Biotechnology, Doctoral School of Sciences and Technology, and Faculty of Public Health, Lebanese University, Tripoli, Lebanon; Centre Hospitalier Universitaire, Clermont-Ferrand, France
DRGs in Transfusion Medicine and Hemotherapy in Germany

Patients requiring transfusion medicine and hemotherapy in an inpatient setting are incorporated into the German Diagnosis Related Groups (G-DRG) system in multiple ways. Different DRGs exist in Major Diagnostic Category 16 for patients that have been admitted for the treatment of a condition from the field of transfusion medicine. However, the reimbursement might be not cost covering for many cases, and efforts have to be intensified to find adequate definitions and prices. We believe that this can only be successful if health service research is intensified in this field. For patients requiring hemotherapy and transfusion medicine concomitant to the treatment of an underlying disease such as cancer, multiple systems exist to increase remuneration, among them the Patient Clinical Complexity Level (PCCL) and complex constellations to induce DRG splits. For direct reimbursement of high cost products, additional remuneration fees (Zusatzentgelte, ZE) are the most important. In addition, expensive innovations not reflected within the DRGs can be reimbursed after application and negotiation of the New Diagnostic and Treatment Methods (Neue Untersuchungs- und Behandlungsmethoden, NUB) system. The NUB system guarantees that medical progress is put rapidly into clinical practice and prevents financial issues from becoming a stumbling block for the use of innovative drugs and methods.
Perception of Visible Speech: Influence of Spatial Quantization

Visible speech reading was studied to determine which features are functional and to test several models of pattern recognition. Nine test syllables differing in their initial consonant were presented in intact form or under various levels of spatial quantization. Performance decreased in increasing quantization but remained relatively good at moderate levels of degradation. Different models were tested against the confusion matrices. Six features were identified as functional in distinguishing among the nine consonant – vowel syllables. These features were used as sources of information in a fuzzy-logical model of perception and an additive model. The fuzzy-logical model provided a significantly better description of the confusion matrices, showing that speech reading is analogous to other domains of pattern recognition such as face recognition and facial-affect perception.
Effects of Moringa oleifera silage on milk yield, nutrient digestibility and serum biochemical indexes of lactating dairy cows

This study investigated the effects of Moringa oleifera (MO) as a partial substitute of alfalfa hay on milk yield, nutrient apparent digestibility and serum biochemical indexes of dairy cows. MO was harvested at 120 days post-seeding. Fresh MO was cut, mixed with chopped oat hay (425:575 on a DM basis), ensiled and stored for 60 days. Sixty healthy Holstein dairy cows were allocated to one of three groups: NM (no MO or control), LM (low MO; 25% alfalfa hay and 50% maize silage were replaced by MO silage) or HM (high MO; 50% alfalfa hay and 100% maize silage were replaced by MO silage). The feeding trial lasted 35 days. The LM and HM diets did not affect dry matter (DM) intake, milk yield or milk composition (lactose, milk fat, milk protein and somatic cell count). The apparent digestibility of DM and NDF was lower for HM group than NM group. Additionally, there were no significant differences in serum biochemical indexes between the LM and NM groups. The HM group had lower serum concentrations of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol and higher serum concentrations of urea than the NM group. The partial replacement of alfalfa hay (≤50%) and maize silage with MO silage had no negative effects on milk yield, in vivo nutrient apparent digestibility or serum biochemical indexes of lactating cows.
A 12.3mW 12.5Gb/s complete transceiver in 65nm CMOS

For the people involved with multi-Gb/s chip-to-chip serial links, reducing power dissipation per Gb/s to less than 1mW/(Gb/s) (i.e., 1pJ/b) has been a long-held goal. Several years ago, the power dissipation of these links was in the range of about 10 to 20mW/(Gb/s). In 2007, Poulton et al. developed a 14mW 6.25Gb/s transceiver with power efficiency of 2.2mW/(Gb/s) [1]. Thereafter, there were some efforts aiming to reduce power of each building block in a transceiver [2, 3]. This paper presents a 12.3mW 12.5Gb/s complete transceiver (including CDR, MUX/DEMUX, and global clock distribution)in 65nm CMOS with power efficiency of 0.98mW/(Gb/s). To achieve low power, a resonant-clock distribution with distributed on-chip inductors and a low-swing voltage-mode driver with pulse-current boosting are used in the transmitter, while a symbol-rate comparator/phase detector using 4-stage sense amplifier and phase-rotating PLL with variable delay are used in the receiver.
Experimental characterization of unstable periodic orbits by controlling chaos.

A modification of the method proposed by Ott, Grebogi, and Yorke to control chaos [Phys. Rev. Lett. 64, 1196 (1990)] has allowed us to characterize unstable orbits of a Nd-doped fiber laser in their whole domain of existence. Stabilization could be achieved both on orbits embedded inside the chaotic attractor and on orbits located in other parts of the phase space. Transient regimes provide direct experimental information on the unstable Floquet multipliers
The fibrin clot; a medium for supporting loose cells and delicate structures during processing for microscopy.

Fibrin clots were used for suspensions; fibrin films for preserving in situ characteristics of conidial chains, delicate fruiting structures, and cellular arrangements of mycetozoa and fungi. A solution containing fibrinogen, 300–350 mg; Na-citrate, 160 mg; and NaCl, 850 mg per 100 ml, was mixed immediately before use, and in the amount needed, with an equal volume of a thrombin solution containing 5–10 units/0.l ml of sterile glass-distilled water. In these proportions, a clot formed within 20–30 sec. Washed suspensions, pelleted by centrifugation, were incorporated into the forming clot by twisting a sharpened applicator stick, first in an overlying activated fibrinogen solution, and then into the pellet until the cell mass was entrapped. Films were prepared either by spreading the activated solution on a coverslip onto which a piece of natural substratum or of agar bearing the desired structures was impressed, or by dropping the activated solution directly on the structures' support.
The turning- and linear-maneuvering performance of birds : the cost of efficiency for coursing insectivores

To examine the performance compromises necessitated by adaptations for high efficiency in flight, such as highaspect ratio wings, the flight morphology and acceleration performance of a guild of coursing aerial insectivores (swifts andswallows) were compared with those of a guild of avian generalists. Though phylogenetic non-independence made inference ofadaptation difficult, biologically significant differences in aspect ratio and acceleration performance probably exist between thetwo groups of birds. A model of aerial insectivory is presented to illustrate the performance demands of this foraging methodand the impacts of the compromises between high efficiency in sustained flight and turning- and linear-maneuveringperformance.
Incremental Robot Shaping

We propose a modular architecture for autonomous robots which allows for the implementation of basic behavioral modules by both programming and training, and accommodates for an evolutionary development of the interconnections among modules. This architecture can implement highly complex controllers and allows for incremental shaping of the robot behavior. Our proposal is exemplified and evaluated experimentally through a number of mobile robotic tasks involving exploration, battery recharging and object manipulation.
Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative

The NIH Xenopus Initiative is establishing many of the genetic and genomic resources that have been recommended by the Xenopus research community. These resources include cDNA libraries, expressed sequence tags, full‐length cDNA sequences, genomic libraries, pilot projects to mutagenize and phenotype X. tropicalis, and sequencing the X. tropicalis genome. This review describes the status of these projects and explains how to access their data and resources. Current information about these activities is available on the NIH Xenopus Web site (http://www.nih.gov/science/models/xenopus/). Published 2002 Wiley‐Liss, Inc.
Automated discovering concurrent models from data tables - an overview of algorithms

Summary form only given. This paper presents an overview of algorithms for automated discovering concurrent models from data tables. Constructed models have the form of coloured Petri nets and can be used to determine different properties concerning structures and behaviours of modeled systems; extract new knowledge about systems or verify their descriptions or specifications. We consider a description of concurrent systems by information systems as well as dynamic information systems.
Therapeutic Modalities for Physical Therapists

Chapter 1 Science of Therapeutic Modalities (William E. Prentice) Chapter 2 Healing Process and Guidelines for Using Therapeutic Modalities (William E. Prentice) Chapter 3 Managing Pain with Therapeutic Modalities (Craig R. Denegar and Phillip B. Donley) Chapter 4 Basic Principles of Electricity (William E. Prentice) Chapter 5 Electrical Stimulating Currents (Daniel N. Hooker) Chapter 6 Iontophoresis (William E. Prentice) Chapter 7 Biofeedback (William E. Prentice) Chapter 8 Shortwave and Microwave Diathermy (William E. Prentice and David O. Draper) Chapter 9 Infrared Modalities (Gerald W. Bell and William E. Prentice) Chapter 10 Therapeutic Ultrasound (David O. Draper and William E. Prentice) Chapter 11 Low Power Lasers (Ethan Saliba and Susan Foreman-Saliba) Chapter 12 Ultraviolet Therapy (J. Marc Davis) Chapter 13 Spinal Traction (Daniel N. Hooker) Chapter 14 Intermittent Compression Devices (Daniel N. Hooker) Chapter 15 Therapeutic Massage (William E. Prentice and Clairbeth Lehn) Chapter 16 Joint Mobilization and Traction (William E. Prentice) Chapter 17 Proprioceptive Neuromuscular Facilitation Techniques (William E. Prentice) Chapter 18 The Physiological Effects of Therapeutic Modality Intervention on the Body Systems (Eric Shamus) Appendix A-1/ Locations of the Motor Points Appendix A-2/Manufacturers and Distributors Addresses Appendix A-3/Units of Measurement
Pharmacology, Physiology, and Mechanisms of Action of Dipeptidyl Peptidase-4 Inhibitors

Abstract Dipeptidyl peptidase-4 (DPP4) is a widely expressed enzyme transducing actions through an anchored transmembrane molecule and a soluble circulating protein. Both membrane-associated and soluble DPP4 exert catalytic activity, cleaving proteins containing a position 2 alanine or proline. DPP4-mediated enzymatic cleavage alternatively inactivates peptides or generates new bioactive moieties that may exert competing or novel activities. The widespread use of selective DPP4 inhibitors for the treatment of type 2 diabetes has heightened interest in the molecular mechanisms through which DPP4 inhibitors exert their pleiotropic actions. Here we review the biology of DPP4 with a focus on: 1) identification of pharmacological vs physiological DPP4 substrates; and 2) elucidation of mechanisms of actions of DPP4 in studies employing genetic elimination or chemical reduction of DPP4 activity. We review data identifying the roles of key DPP4 substrates in transducing the glucoregulatory, anti-inflammatory, and cardiometabolic actions of DPP4 inhibitors in both preclinical and clinical studies. Finally, we highlight experimental pitfalls and technical challenges encountered in studies designed to understand the mechanisms of action and downstream targets activated by inhibition of DPP4.
RGB-D object recognition with multimodal deep convolutional neural networks

Object recognition from RGB-D images has become a hot topic and gained a significant popularity in recent years due to its numerous applications. In this paper, we propose a novel multimodal deep convolutional neural networks architecture for RGB-D object recognition which composed of three streams with two different types of deep CNNs, where each stream can separately learn from each modality. Finally, we propose a combined architecture of joint network of these three streams to classify the objects. Compared to RGB data, RGB-D images provide additional depth information that can be represented as depth colorization methods or surface normals. Our goal is to exploit both colorization and surface normals information to encode depth images. We show that by utilizing both colorization and surface normals of depth images combined with RGB significantly can improves the classification accuracy. We evaluate our model on one of the most challenging RGB-D object dataset and achieves comparable performance to state-of-the-art methods.
Increased Risk of Blount Disease in Obese Children and Adolescents With Vitamin D Deficiency

Background Poor dietary habits and decreased outdoor activity has led to an epidemic of obese children and vitamin D deficiency. The lack of vitamin D alters bone development and mineralization by diminishing physiological levels of calcium and phosphorus. Given vitamin D's role in bone and growth plate mineralization and regulation, we hypothesized that vitamin D deficiency would lead to higher rates of fractures, slipped capital femoral epiphysis (SCFE), and Blount disease in obese youth. Methods A retrospective review was performed at the obesity clinic using the obesity database (890 patients). Data obtained included body mass index (BMI), vitamin D levels (25-vitamin D), history of fractures, Blount disease, and/or SCFE. The chart review identified 2 populations of obese patients, those with vitamin D deficiency, <16 ng/mL (198 patients) and those not vitamin D deficient >16 ng/mL (692 patients). Fisher exact, &khgr;2, and 2-sample t tests along with logistic regression were used for statistical analysis. A P value ⩽0.05 was considered statistically significant. Results Blount disease was found to have a statistically significant (P<0.05) positive association with patient's sex, BMI, and vitamin D level. Specifically, males were 8.16 times more likely than females to be observed with Blount disease (P=0.01). Patients with very low vitamin D levels were 7.33 times more likely to have Blount disease than patients with higher levels (P=0.002). Each whole number increase in BMI increases the likelihood of Blount disease by 3% (P=0.01). There was no association between increased number of fractures or SCFE with vitamin D deficiency in these obese patients. Conclusion As our findings indicate, BMI and vitamin D levels have a strong association with Blount disease, which may be especially important among males. Ours is the first study to show a relationship between vitamin D deficiency and Blount disease, but further prospective studies are needed with larger numbers to confirm this independent association of vitamin D deficiency with Blount disease. Level of Evidence Level III retrospective study.
Achieving 3D-MIMO With Massive Antennas From Theory to Practice With Evaluation and Field Trial Results

Exploiting multiple-input–multiple-output (MIMO) techniques by using massive antennas can significantly improve the capacity and reliability of wireless systems and has been considered as one key technique in future fifth-generation mobile communications system. Considering the limitation of antenna panel size, placing the massive antennas in 2-D grid is an effective way for its commercialization, which is termed as “3D-MIMO. ” In this paper, we study the performance of 3D-MIMO with massive antennas by system-level simulation using practical assumption and 3-D channel model and test the 3D-MIMO in field trial with commercial terminal and networks. In addition, we compare the system-level simulation results and the field trial test measurements. Our system-level simulation results show that the 3D-MIMO with 64 antennas can significantly improve the performance with 56% and 147% gain on cell-average and cell-edge throughputs compared with 2D-MIMO. We perform field trial to test the 3D-MIMO, and the results verify its performance gain obtained by simulation. Furthermore, the measurement in typical high-rise scenario shows that the 3D-MIMO can significantly enhance the data rate of users located at higher floors due to the capability of flexible elevation beamforming.
Randomized Controlled Trials on PET: A Systematic Review of Topics, Design, and Quality

Randomized controlled trials (RCTs) add important information to diagnostic accuracy studies in the evaluation of PET and PET/CT. We evaluated how many RCTs on PET existed, which clinical topics they addressed, and what their design and quality were. Methods: We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials (Clinical Trials) up to August 2010. We also searched in ClinicalTrials.gov and the International Clinical Trials Registry Platform for ongoing RCTs up to March 2011. Titles and abstracts and full texts were screened independently by 2 reviewers. Study characteristics were extracted with standard extraction sheets for ongoing and published RCTs, and risk of bias was assessed for published ones. Results: We identified 54 RCTs, 12 of which were published. The main topics in published studies were non–small cell lung cancer and colorectal cancer; only 3 were conducted in nononcologic fields (this trend was similar in ongoing studies, in which the most common topic was Hodgkin disease). The main indications in the oncologic PET studies were staging in published studies and restaging (mostly including an early assessment of treatment response) in ongoing ones. All except 1 of the published studies applied a marker-based strategy design, whereas about 43% (18/42) of ongoing studies use a more efficient design (Enrichment Design or Marker by Treatment Interaction Design). Conclusion: A relatively high number of ongoing RCTs of PET in several oncologic fields are expected to produce robust results over the next few years. For nononcologic topics, further high-quality studies are still needed to ascertain the benefit of this technique for patients. As funding is usually difficult in nondrug topics, alternative concepts of funding, which should also involve the manufacturers of diagnostic devices, but also more efficient study designs, should be applied to bridge the evidence gap on PET in the near future.