Miracle-dz/UniFAR-FTUs huggingface dataset:
Isolated Medial Orbital Wall Fractures With Medial Rectus Muscle Incarceration

Purpose: To retrospectively review and analyze cases of isolated medial orbital wall fractures with medial rectus muscle incarceration presenting to a tertiary ophthalmic plastic surgery practice from 1997 to 2005. Methods: Retrospective chart review and literature review. Results: Nine cases of isolated medial wall fracture with medial rectus muscle incarceration are presented. The most frequently encountered clinical feature was adduction deficit on the affected side. Extraocular motility improved in all patients who underwent surgery, and mean postoperative enophthalmos was minimal. Conclusions: Isolated medial orbital wall fractures with medial rectus muscle incarceration are rare. Ocular motility abnormalities were the only indication of underlying fracture in the majority of our cases. Clinicians should be alerted to the anticipated presentation of medial wall fractures with incarceration of the medial rectus muscle, including the possibility of a “white eye” and normal abduction of the traumatized eye.
Health care analysis for process deviation using alpha-fitness algorithm in process mining

Health care sectors are continuously exploring new and innovative way to improve operational efficiencies. This research study investigate a way to find potential efficiency gains in healthcare sectors by observing how they are carried out in the past and then investigating better ways of implementing them by considering the factors like time, cost and resource utilization. To achieve competitive advantage, healthcare centers try and contour their processes. Process mining can be enforced to extract data from recorded event. The aim of the system is to propose effective process models by applying dataset for each model which indeed identifies the deviation from the actual process with help the of analytical tool ProM. In this paper several blood tests are considered as the baseline scenario wherein effective process models are generated and checked for the efficiency using alpha-fitness algorithm. One of the major parts involved in process improvement is process modeling which can be optimized and analyzed.
A Reexamination of the Dilution of Auditor Misstatement Risk Assessments: An Experimental Study of the Impact of Client Information Type, Workload, and PCAOB Guidance on Dilution

Many external parties such as investors, creditors, and regulatory agencies, use a company’s financial statements in their decision-making. In doing so, they rely on audit opinions on whether financial statements are fairly stated. However, evidence suggests that there are factors in the audit environment that influence auditor judgments. For example, nondiagnostic client information dilutes auditor judgments when compared to judgments based on diagnostic information alone, especially for less experienced auditors (Hackenbrack 1992; Hoffman and Patton 1997; Glover 1994; Shelton 1999). High time pressure conditions mitigate this effect by refocusing auditor attention toward relevant client information, therefore reducing the impact of nondiagnostic information (Glover 1994, 1997). This research study examines other common audit environment factors to determine if they too influence audit judgment results. An online questionnaire of 149 auditors, CPAs and other accounting professionals indicate that the inclusion of nondiagnostic client information results in a significant change in auditor judgments. The direction of this change follows a theorized pattern; risk assessments that were initially high are reduced, while those that were initially low are increased. Significance was not consistently found for a workload and PCAOB effect on auditor judgment. However, a comparison of the absolute value of dilution effect means across conditions reveals some trending for the proposed unwanted effect of high workload, and the beneficial effect of PCAOB guidance. These results have important implications for auditing research and practice. It extends previous archival research on workload effects and uses a unique questionnaire design to reexamine workload pressures in a behavioral setting. The results of hypothesis testing on workload pressure and PCAOB guidance, although lacking consistent statistical significance; exhibit trends that agree with proposed theoretical relationships. Tests on the effects of nondiagnostic information show strong statistical support for previous studies in the area of psychology and audit. This study’s greatest contribution suggests that audit pressures do not produce equivalent effects on auditor judgment; time pressure improves audit judgment, while workload pressure does not (Glover 1994, 1997). These results can be explained by examining the relationship between stress and audit judgment performance (Choo 1995, Yerkes and Dodson 1908). Different types and different degrees of audit pressures may correspond to different levels of audit pressure. Low to moderate levels of audit pressure, such as the level of time pressure used in Glover’s (1994, 1997) study improve audit performance. Higher audit pressures, such as high workload during an auditor’s busy season, may lower audit performance.
Unusual Morphologic Features of Endometrial Stromal Tumors: A Report of 2 Cases

Endometrial stromal tumors with typical morphology usually do not pose diagnostic problems. However, the finding of unusual morphologic features may be misleading in the final interpretation of these tumors. Herein, we described two endometrial stromal sarcomas discovered in hysterectomy specimens of women 31 and 75 years of age. Features typical of endometrial stromal neoplasia were present in both cases. Additionally, in 1 case, extensive fatty metaplasia as well as smooth and skeletal muscle metaplasia were found; and in the second case, focal bizarre nuclei, smooth muscle differentiation, and fibrous change were present. The differential diagnosis in the first case included cellular intravenous leiomyomatosis/lipoleiomyomatosis with skeletal muscle differentiation; and in the second case, a cellular smooth muscle tumor with bizarre nuclei was considered.
NURSING CARE & Management of Pathological Oral Conditions Among Women and Children

Oral health is receiving increased recognition as an important factor for the health of women and children. This article describes pathological oral conditions and the physiological mechanisms involved in the maintenance of oral health during illness and hospitalization, including the importance of the production and secretion of adequate saliva. Alterations in physiology of saliva induced by hormonal changes that occur during pregnancy are described along with possible roles in pathophysiological conditions associated with pregnancy. The roles of xerostomia and periodontal disease as sources of pathological bacteria involved in aspiration pneumonia, ventilator-associated pneumonia, and chronic inflammation are described. The bidirectional interaction between oral health and general overall health is described, with special emphasis on cardiovascular disease. Specific evidence-based nursing measures to reduce the complications associated with poor oral health in at-risk patients are provided.
The Relation Between a Prior Earnings Forecast by Management and Analyst Response to a Current Management Forecast

This paper investigates whether the accuracy of a prior earnings forecast by management serves as an indicator to analysts of the believability of a current management forecast. Regression analysis is used to examine the relation- ship between the usefulness of a prior forecast by management and analyst response to a current forecast, after controlling for other determinants of believabil- ity. The results suggest that management establishes a forecasting "reputation" based on prior earnings forecasts. Data Availability: A list of sample firms is available from the author upon request. With the exception of the analysts' forecasts which were obtained through the Institutional Brokers Estimate System (IIB/EIS), the data used in this study are from public sources identified in the text.
Effect of ultraviolet light on the expression of genes for human U1 RNA

Two types of UV‐light‐induced inhibitions of the synthesis of small nuclear RNA species U1, U2, U3, U4, and U5 were described previously: an immediate inhibition and a separate, delayed suppression that requires 1‐2 hr of postirradiation cell incubation and UV doses that are about tenfold lower. In the present report, U1 RNA transcription in isolated nuclei from HeLa cells, assayed by RNAase T1 protection, reproduced the delayed inhibition. The sizes of the protected RNA fragments suggest that it is the initiation of U1 RNA transcription that is blocked during this inhibition. Transient expression of a marked human U1 RNA gene that contains 425 and 92 nucleotides of the 5′ and 3′ flanking sequences, respectively, showed delayed, but not immediate inhibition (while the endogenous U1 RNA genes exhibited immediate suppression). This indicates that continuity of the U1 gene flanking sequences beyond those segments and/or chromosomal integration of the U1 gene are not needed for the delayed inhibition, but may be required for the immediate inhibition. Irradiation of a U1 RNA gene, followed by its injection into Xenopus laevis oocyte nuclei, did not reproduce the immediate or delayed inhibitions. This suggests that direct UV radiation damage to DNA in the U1 RNA gene region is not the critical lesion in either the immediate or delayed UV‐light‐induced inhibitions of U1 RNA synthesis. In addition, the RNAase T1 protection pattern of transcripts synthesized in isolated nuclei from nonirradiated HeLa cells suggests that these cells may produce small amounts of U1 RNA molecules with variant nucleotide sequences in the mature region of the transcript.
Synergistic Effects of NDRG2 Overexpression and Radiotherapy on Cell Death of Human Prostate LNCaP Cells

Background: Radiation therapy is among the most conventional cancer therapeutic modalities with effective local tumor control. However, due to the development of radio-resistance, tumor recurrence and metastasis often occur following radiation therapy. In recent years, combination of radiotherapy and gene therapy has been suggested to overcome this problem. The aim of the current study was to explore the potential synergistic effects of N-Myc Downstream-Regulated Gene 2 (NDRG2) overexpression, a newly identified candidate tumor suppressor gene, with radiotherapy against proliferation of prostate LNCaP cell line. Materials and Methods: In this study, LNCaP cells were exposed to X-ray radiation in the presence or absence of NDRG2 overexpression using plasmid PSES- pAdenoVator-PSA-NDRG2-IRES-GFP. The effects of NDRG2 overexpression, X-ray radiation or combination of both on the cell proliferation and apoptosis of LNCaP cells were then analyzed using MTT assay and flow cytometery, respectively. Results: Results of MTT assay showed that NDRG2 overexpression and X-ray radiation had a synergistic effect against proliferation of LNCaP cells. Moreover, NDRG2 overexpression increased apoptotic effect of X-ray radiation in LNCaP cells synergistically. Conclusion: Our findings suggested that NDRG2 overexpression in combination with radiotherapy may be an effective therapeutic option against prostate cancer.
Performance Improvement of a U-Slot Patch Antenna Using a Dual-Band Frequency Selective Surface With Modified Jerusalem Cross Elements

A dual-band FSS consisting of regular Jerusalem cross elements was first used to study its impact on the bandwidths and resonant frequencies of a U-slot patch antenna. Based on the simulation experience of the first partial study, another FSS with modified Jerusalem cross elements was proposed to improve the bandwidths, antenna gains, and return losses of a smaller U-slot patch antenna at 2.45 and 5.8 GHz for Bluetooth and WLAN applications, respectively. Measured data of the return loss, radiation pattern, and antenna gain of this smaller U-slot patch antenna were also presented. It is proven that the smaller U-slot patch antenna implanted with a FSS consisting of modified Jerusalem cross elements has a good performance with sufficient bandwidth and higher gain and is capable of dual-band operation.
Noninvasive intratissue refractive index shaping (IRIS) of the cornea with blue femtosecond laser light.

PURPOSE To test the feasibility of intratissue refractive index shaping (IRIS) in living corneas by using 400-nm femtosecond (fs) laser pulses (blue-IRIS). To test the hypothesis that the intrinsic two-photon absorption of the cornea allows blue-IRIS to be performed with greater efficacy than when using 800-nm femtosecond laser pulses. METHODS Fresh cat corneas were obtained postmortem and cut into six wedges. Blue laser pulses at 400 nm, with 100-fs pulse duration at 80 MHz were used to micromachine phase gratings into each corneal wedge at scanning speeds from 1 to 15 mm/s. Grating lines were 1 μm wide, 5 μm apart, and 150 μm below the anterior corneal surface. Refractive index (RI) changes in micromachined regions were measured immediately by recording the diffraction efficiency of inscribed gratings. Six hours later, the corneas were processed for histology, and TUNEL staining was performed to assess whether blue-IRIS causes cell death. RESULTS Scanning at 1 and 2 mm/s caused overt corneal damage in the form of bubbles and burns. At faster scanning speeds (5, 10, and 15 mm/s), phase gratings were created in the corneal stroma, which were shown to be pure RI changes ranging from 0.037 to 0.021 in magnitude. The magnitude of RI change was inversely related to scanning speed. TUNEL staining showed cell death only around bubbles and burns. CONCLUSIONS Blue-IRIS can be performed safely and effectively in living cornea. Compared with near-infrared laser pulses, blue-IRIS enhances both achievable RI change and scanning speed without the need to dope the tissue with two-photon sensitizers, increasing the clinical applicability of this technique.
The Effect of Vitamin C and Glutathione on Ethanol Cytotoxicity and Selected Parameters of Pro-and Antioxidative Processes in Mouse Fibroblasts 3 T 3L 1

Ethanol metabolites may directly or indirectly induce oxidative stress as a result of disturbed balance between proand antioxidative processes. An indirect effect of ethanol on the generation of oxidative stress is associated with the attenuation of intracellular defensive enzymatic antioxidants, e.g. gluthatione peroxidase, catalase, superoxide dismutase as well as waterand/or fat-soluble low-molecular antioxidants (e.g., vitamin C, vitamin E, glutathione, selenium). The aim of our study was to evaluate the effect of 48h preincubation of mouse embryo fibroblast-like cells (3T3-L1) with vitamin C (VC, 0.06 mM) and glutathione (GSH, 0.05 mM) on their viability after exposure for 4, 8, and 24 h to ethanol (0.3 mM). Additionally, the activity of glutathione peroxidase (GSHPx) and thioredoxin reductase (TrxR) enzymes as well as the level of thiobarbituric acid reactive substances (TBARS) were assessed in the exposed cells. In our study, vitamin C and glutathione had no significant effect on cytotoxicity of ethanol. We observed differences in GSH-Px and TrxR activity depending on the duration of exposure to ethanol. The highest GSH-Px activity in cell lysates was measured after 8 and 24h of incubation with ethanol and both antioxidants, or ethanol alone. The highest TrxR activity was observed after 4h of incubation in the presence of ethanol or GSH. There were no effects of VC and GSH on the activity of the antioxidant enzymes in comparison to cells not supplemented with VC and GSH. Similarly, we were unable to show any significant differences in levels of TBARS except incubation for 24h, when concentration of TBARS was highest in cells exposed to ethanol and simultaneously supplemented with the antioxidants.
Hepatoprotective aliphatic glycosides from three Goodyera species.

Hepatoprotective aliphatic glycosides 3-(S)-3-beta-D-glucopyranosyloxybutanolide (1) and its congener, 3-(S)-3-beta-D-glucopyranosyloxy-4-hydroxybutanoic acid (2) were isolated as major constituents from the whole plants of three Goodyera species, G. schlechtendaliana Reichb. fil. , G. matsumurana Schltr. and G. discolor Ker-Gawl. The structures of 1 and 2 have been determined by NMR, MS spectroscopic and chemical means. Compound 1 was converted into its methyl ester form (5) during the purification step, when the lactone ring was cleaved by catalysis of silica gel with the CHCl3-MeOH-H2O as a solvent. On the other hand, 1 was obtained in a high yield by the same purification procedure without MeOH. Based on this fact, a simple and economic method for the purification of 1 was confirmed. Compounds 1 and 2 were found to have a hepatoprotective effect on liver injury induced by carbon tetrachloride in primary cultured rat hepatocytes.
Once- versus twice-daily direct oral anticoagulants in non-valvular atrial fibrillation

ABSTRACT Introduction: Direct oral anticoagulants (DOACs) have emerged as alternatives to vitamin K antagonists for the prevention of stroke in patients with non-valvular atrial fibrillation (NVAF). Four DOACs: dabigatran, rivaroxaban, apixaban and edoxaban, are currently available. In the absence of head-to-head clinical comparisons of DOACs, dosing regimen may influence drug choice. Areas covered: Edoxaban and rivaroxaban are administered once daily, dabigatran and apixaban twice daily. The selection of these dosage regimens is largely based on studies for the prevention or treatment of venous thromboembolism or acute coronary syndrome. Edoxaban is the only DOAC in which once and twice-daily regimens were compared in patients with NVAF; bleeding rates were higher in the twice-daily groups. Once-daily versus twice-daily regimens have a number of practical implications. Missing a once-daily dose would have a greater impact on anticoagulation. Some real world and retrospective studies found that a once-daily dosing regimen leads to better adherence and persistence to therapy, an important consideration for maintaining optimum anticoagulation. However, other studies have not found increased adherence among once daily regimens. Expert opinion: Prescription of DOACs should be tailored to the individual patient and dosing regimen is only one of the variables that should be taken into account.
Approaches to Co-Evolution of Metamodels and Models: A Survey

Modeling languages, just as all software artifacts, evolve. This poses the risk that legacy models of a company get lost, when they become incompatible with the new language version. To address this risk, a multitude of approaches for metamodel-model co-evolution were proposed in the last 10 years. However, the high number of solutions makes it difficult for practitioners to choose an appropriate approach. In this paper, we present a survey on 31 approaches to support metamodel-model co-evolution. We introduce a taxonomy of solution techniques and classify the existing approaches. To support researchers, we discuss the state of the art, in order to better identify open issues. Furthermore, we use the results to provide a decision support for practitioners, who aim to adopt solutions from research.
Creative Arts Therapy Improves Quality of Life for Pediatric Brain Tumor Patients Receiving Outpatient Chemotherapy

This mixed methods pilot study evaluated the effects of the creative arts therapy (CAT) on the quality of life (QOL) of children receiving chemotherapy. A 2-group, repeated measures randomized design compared CAT with a volunteer’s attention (n = 16). Statistical analysis of the randomized controlled phase of the study suggested an improvement in the following areas after the CAT: parent report of child’s hurt (P = .03) and parent report of child’s nausea (P = .0061). A nonrandomized phase, using a different instrument showed improved mood with statistical significance on the Faces Scale (P < .01), and patients were more excited (P < .05), happier (P < .02), and less nervous (P < .02). Provider focus groups revealed positive experiences. Case studies are included to exemplify the therapeutic process. With heightened interest in complementary therapy for children with cancer, future research with a larger sample size is needed to document the impact of incorporating creative arts into the healing process.
Recent Advances in Development of Functional Spider Silk-Based Hybrid Materials

Silkworm silk is mainly known as a luxurious textile. Spider silk is an alternative to silkworm silk fibers and has much more outstanding properties. Silk diversity ensures variation in its application in nature and industry. This review aims to provide a critical summary of up-to-date fabrication methods of spider silk-based organic-inorganic hybrid materials. This paper focuses on the relationship between the molecular structure of spider silk and its mechanical properties. Such knowledge is essential for understanding the innate properties of spider silk as it provides insight into the sophisticated assembly processes of silk proteins into the distinct polymers as a basis for novel products. In this context, we describe the development of spider silk-based hybrids using both natural and bioengineered spider silk proteins blended with inorganic nanoparticles. The following topics are also covered: the diversity of spider silk, its composition and architecture, the differences between silkworm silk and spider silk, and the biosynthesis of natural silk. Referencing biochemical data and processes, this paper outlines the existing challenges and future outcomes.
Long noncoding RNA H19 competitively binds miR‐17‐5p to regulate YES1 expression in thyroid cancer

The long noncoding RNA H19 is overexpressed in many cancers and acts as an oncogene. Here, we investigated the role of H19 in thyroid carcinogenesis and its relation to microRNA miR‐17‐5p and its target gene YES1. H19 expression was higher in tumor samples and in thyroid cancer cell lines than nontumor tissues and normal thyroid cells. H19 knockdown and ectopic expression in the TPC‐1 and NIM thyroid cancer cell lines showed that overexpression of H19 promoted proliferation, migration, and invasion, whereas H19 knockdown reduced cell viability and invasion and induced growth arrest in vitro and in vivo. H19 was identified as a target of miR‐17‐5p, by Dual‐Luciferase Reporter assays and RNA‐binding protein immunoprecipitation assays. H19 antagonized the function of miR‐17‐5p on upregulation of its target YES1 and inhibited miR‐17‐5p‐induced cell cycle progression. Our results suggest that H19 functions as a competitive endogenous RNA (ceRNA) by acting as a sink for miR‐17‐5p, revealing a potential ceRNA regulatory network involving H19 and miR‐17‐5p with a role in the modulation of YES1 expression. This mechanism may contribute to a better understanding of thyroid cancer pathogenesis and provide new insights into the treatment of this disease.