Miracle-dz/UniFAR-FTUs huggingface dataset:
Co-transplantation of human hematopoietic stem cells and human breast cancer cells in NSG mice

Humanized tumor mice (HTM) were generated by the co-transplantation of human hematopoietic stem cells and human breast cancer cells overexpressing HER2 into neonatal NOD-scid IL2Rγnull (NSG) mice. These mice are characterized by the development of a human immune system in combination with human breast cancer growth. Due to concurrent transplantation into newborn mice, transfer of MHC-mismatched tumor cells resulted in solid coexistence and immune cell activation (CD4+ T cells, natural killer cells, and myeloid cells), but without evidence for rejection. Histological staining of the spleen of HTM revealed co-localization of human antigen-presenting cells together with human T and B cells allowing MHC-dependent interaction, and thereby the generation of T cell-dependent antibody production. Here, we investigated the capability of these mice to generate human tumor-specific antibodies and correlated immunoglobulin titers with tumor outgrowth. We found detectable IgM and also IgG amounts in the serum of HTM, which apparently controlled tumor development when IgG serum concentrations were above 10 µg/ml. Western blot analyses revealed that the tumor-specific antibodies generated in HTM did not recognize HER2/neu antigens, but different, possibly relevant antigens for breast cancer therapy. In conclusion, HTM offer a novel approach to generate complete human monoclonal antibodies that do not require further genetic manipulation (e. g., humanization) for a potential application in humans. In addition, efficacy and safety of the generated antibodies can be tested in the same mouse model under human-like conditions. This might be of particular interest for cancer subtypes with no currently available antibody therapy.
Primary structure and mapping of the hupA gene of Salmonella typhimurium

In bacteria, the complex nucleoid structure is folded and maintained by negative superhelical tension and a set of type II DNA-binding proteins, also called histonelike proteins. The most abundant type II DNA-binding protein is HU. Southern blot analysis showed that Salmonella typhimurium contained two HU genes that corresponded to Escherichia coli genes hupA (encoding HU-2 protein) and hupB (encoding HU-1). Salmonella hupA was cloned, and the nucleotide sequence of the gene was determined. Comparison of hupA of E. coli and S. typhimurium revealed that the HU-2 proteins were identical and that there was high conservation of nucleotide sequences outside the coding frames of the genes. A 300-member genomic library of S. typhimurium was constructed by using random transposition of MudP, a specialized chimeric P22-Mu phage that packages chromosomal DNA unidirectionally from its insertion point. Oligonucleotide hybridization against the library identified one MudP insertion that lies within 28 kilobases of hupA; the MudP was 12% linked to purH at 90.5 min on the standard map. Plasmids expressing HU-2 had a surprising phenotype; they caused growth arrest when they were introduced into E. coli strains bearing a himA or hip mutation. These results suggest that IHF and HU have interactive roles in bacteria.
Faktor-Faktor Yang Mempengaruhi Tingkat Profitabilitas Bank Pembiayaan Rakyat Syariah (BPRS) Di Aceh

Profitabilitas bank merupakan kualitas yang dinilai berdasarkan keadaan dan kemampuan suatu bank dalam menghasilkan laba. Penelitian ini bertujuan untuk menguji faktor-faktor yang mempengaruhi tingkat profitabilitas Bank Pembia yaan Rakyat Syariah (BPRS) di Aceh. Profitabilitas dalam penelitian ini diukur dengan menggunakan dua rasio, yaitu return on asset dan return on equity, dengan menggunakan empat faktor yaitu pembiayaan, dana pihak ketiga, financing to deposit ratio dan non performing financing. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif.Adapun sampel yang digunakan adalah Bank Pembiayaan Rakyat Syariah (BPRS) di Aceh yang berjumlah 10 bank dan dipilih berdasarkan metode purposive sampling dengan 140 data pengamatan.Pengamatan dilakukan dari tahun 2010 sampai dengan kuartal III tahun 2015. Hasil penelitian dapat disimpulkan bahwa secara simultan variabel pembiayaan, dana pihak ketiga, financing to deposit ratio dan non performing financing berpengaruh signifikan terhadap return on asset dan return on equity. Untuk pengujian secara parsial, seluruh variabel independen yaitu pembiayaan, dana pihak ketiga, financing to deposit ratio dan non performing financing berpengaruh signifikan terhadap return on asset. Sedangkan terhadap return on equity, hanya variabel dana pihak ketiga dan financing to deposit ratio yang berpengaruh signifikan. Adapun variabel pembiayaan dan non performing financing tidak berpengaruh signifikan terhadap return on equity.
Wideband Filtering Power Divider With Ultra-Wideband Harmonic Suppression and Isolation

In this paper, a wideband filtering power divider (PD) with ultra-wideband harmonic suppression and isolation is proposed. The dual coupled-line sections are embedded to the conventional quarter-wavelength transmission lines, which helps to extend the passband of the PD. With the introduction of the short-circuit stubs shunted at the output ports and the coupled lines with the open-circuit stubs, the ultra-wide stopband can be implemented more efficiently, thus resulting in five transmission zeros from 2 to 6 GHz. Furthermore, the improved isolation structure with series connected a resistor and a capacitor can be utilized to realize the ultra-wide isolation frequency band. Using a single resistor between two output ports, we have achieved an excellent in-band isolation. For demonstration, a wideband filtering PD operating at 1 GHz with a 20-dB bandwidth of 50% and an ultra-wide stopband better than 20 dB from 2 to 6 GHz is designed, fabricated, and measured. The measured results agree well with the anticipation.
Effect of duration of ischemia on myocardial proteome in ischemia/reperfusion injury

Ischemia/reperfusion (I/R) injury is a serious problem resulting from clinical setting of coronary revascularization. Despite extensive studies on I/R injury, the molecular bases of cardiac dysfunction caused by I/R are still unknown, but are likely to result from alterations in protein expression. Isolated rat hearts were subjected to 15–30 min of no‐flow ischemia without (Ischemia protocol) or with 30 min of reperfusion (I/R protocol). 2‐DE analysis of heart proteins from both experimental protocols showed wide‐ranging changes in protein levels. In the Ischemia protocol, 39 protein spots were changed in ischemic groups and those changes correlated with duration of ischemia. Ninety percent of the affected proteins were increased. In contrast to increased protein levels, the total messenger RNA (mRNA) level decreased approximately two fold. Compared to the Ischemia protocol, changes in protein levels in the I/R protocol did not correlate with the duration of ischemia and the degree of recovery of mechanical function. The decrease of affected protein from I/R protocol was associated with the increase in total protein level in reperfusate. Our studies show that the protein increase is correlated with the mechanical function of the I/R hearts and the increase is not likely associated with an increase in protein synthesis.
BOARD COMPOSITION, OWNERSHIP CONCENTRATION, AND VOLUNTARY INTERNET DISCLOSURE BY MSM-LISTED COMPANIES

The purpose of this paper is to examine the determinants and characteristics of voluntary internet disclosures by listed companies in Oman. This paper uses archival data from listed companies on Muscat Securities Market (MSM). Binary Logistic Regression analysis is used to examine the determinants of internet financial reporting. The results of this study reveal that ROA is one of the factors that impacts internet financial reporting. Also, the results reveal that ownership concentration has a negative effect on the internet financial disclosure. The paper provides insights into corporate internet disclosures in the GCC countries that will benefit all stakeholders with an interest in corporate reporting in this important region of the world.
GntP Is the Escherichia coli Fructuronic Acid Transporter and Belongs to the UxuR Regulon

ABSTRACT Escherichia coli has four gluconate transporters, GntP, GntU, GntT, and IdnT, which are members of the major facilitator superfamily. The physiological function of GntP was previously unknown and is the subject of this study. GntP is not induced by gluconate, and despite being located adjacent to genes involved in glucuronate catabolism, gntP does not encode a glucuronate transporter. Here we identify gntP as the gene which encodes the fructuronate transporter. We show that gntP is induced by fructuronate and is a new member of the UxuR regulon: gntP is derepressed in an uxuR strain, UxuR binds in vitro specifically to an operator site that overlaps the gntP promoter, and UxuR binding is eliminated by fructuronate. Transcription of gntP requires activation by cyclic AMP (cAMP)-cAMP receptor protein. A gntP mutant cannot grow on fructuronate but grows normally on glucuronate and gluconate. Thus, the UxuR regulon is a module of sugar acid catabolism whose physiological role is for growth on fructuronate. Glucuronate, because it proceeds through a fructuronate intermediate, must induce the UxuR regulon and must also induce the ExuR regulon, which encodes the glucuronate transporter, ExuT, and the first step in its catabolism, UxaC. Thus, hexuronate catabolism in E. coli requires both the ExuR and UxuR regulons, while fructuronate catabolism requires only the UxuR regulon.
An All-Region I–V Model for 1-D Nanowire MOSFETs

An all-region short-channel MOSFET, model is developed for nanowire semiconductors with 1-D density of states. It is shown that in the quantum capacitance limit, the long-channel saturation current exhibits a (<italic>V<sub>gs</sub> </italic> − <italic>V<sub>t</sub></italic>)<sup>3/2</sup> dependence on gate voltage. With the velocity saturation effect implemented in the model, the <italic>I<sub>ds</sub></italic>–<italic>V<sub>gs</sub></italic> characteristics of 1-D MOSFETs are compared to those of 2-D MOSFETs at 10-nm channel length. The above threshold model is joined with a subthreshold current model derived from short-channel solutions to form an <italic>I</italic>– <italic>V</italic> model continuous in all regions.
Mentoring as a Developmental Tool for Higher Education.

Higher education, a setting devoted to the enhancement of learning, inquiry, and development, continues to lack effective development for faculty. Mentoring relationships seek to provide enhancement, yet few mentoring programs exist. This literature review examines forms of mentoring, its benefits, barriers to implementation, means for successful implementation, and the alignment of mentoring practice with theory. Drawing on the Marsick and Watkins model of informal and incidental learning, a model of mentoring in higher education is proposed.
Cellular automata for deterministic sequential test pattern generation

This paper addresses the issue of identifying a Cellular Automaton able to generate deterministic input patterns to detect stuck-at faults inside an FSM. A suitable hardware structure is first identified. An evolutionary algorithm is then proposed, which directly identifies a Cellular Automaton able to reach a very good Fault Coverage. The novelty of the method consists in combining the generation of test patterns with the synthesis of a Cellular Automaton able to reproduce them. Experimental results are provided, which show that the proposed hardware architecture and algorithmic approach outperform more traditional solutions, based on ATPG tools and FSM synthesis, from the point of view of both applicability and area occupation, while reaching the same Fault Coverage.
DESIGN, PRODUCTION, AND UTILIZATION OF LONG OLIGONUCLEOTIDE MICROARRAYS FOR EXPRESSION ANALYSIS IN MAIZE

Analysis of gene expression on a genome scale can provide useful insights into plant growth and development, and an understanding of the mechanisms used by plants to cope with biotic and abiotic stress. To facilitate analysis of genome-wide gene expression in maize, we have assembled a large collection of maize EST and genomic sequences, designed a set of 57,442 maize 70-mer oligonucleotides to represent these sequences, and printed a two-slide microarray set (MOA and MOB) which is available to the maize research community at minimal cost. To monitor array quality, we have devel- oped a series of printing controls and procedures that when coupled with a 9-mer hybridization assay, allow tracking of spot morphology and printing pin carryover. An optimized hybridization protocol has been developed by testing a series of hybridization temperatures and per- forming detailed statistical analyses. To facilitate manage- ment of all long-oligonucleotide associated array data, Zeamage, a Sybase relational database has been devel- oped and is available at www.maizearray. org. Zeamage contains the appropriate tables and fields for tracking the oligonucleotide sequences and associated annotation, ar- ray design, and biological information associated with the microarray hybridizations. The www.maizearray. org web- site provides additional information on the project, array content, and data analysis tools.
Determinants of lending volume in the Kenyan banking industry: a survey of selected commercial banks in Nairobi Kenya

Banking institutions play a major role in economic growth and development through provision of credit to execute economic activities. There is a broad body of literature that addresses issues of bank lending behavior. However, little effort has been devoted to explaining what determines within country variation of the supply side (banks) choices in their lending practices. This study, therefore sought to establish the determinants of lending within the country from the supply side. The study explored the effect of volume of deposit, interest rate and liquidity ratio on total loan advanced by selected commercial banks in Nairobi, Kenya. This research employed a descriptive correlation research design and was informed by theory of Money Supply. The population of study constituted all the ten banks that were listed at the Nairobi Securities Exchange (NSE) as at the year 2012. Purposeful sampling technique was used to constitute a sample size of nine commercial banks in this study. Co-operative Bank of Kenya was therefore excluded as it was listed in the NSE market in the year 2008. The study focused on a ten-year period analysis (2002-2011) of the comprehensive financial statements of all commercial banks listed by NSE. A data collection form was used to collect data through document analysis. The study used both descriptive and inferential statistics in the analysis. The study adopted an econometric approach to test the degree of correlation between the variables by employing the multiple regression analysis of the Ordinary Least Square (OLS) method. The findings indicated that lending interest rates are negatively related and significantly affect the total loans advanced. With regard to the liquidity, this study revealed that banks with more liquid assets extend more credit to borrowers. Further, volume of deposit in commercial banks has a significant and positive effect on the total loan advanced and that the liquidity ratio also positively and significantly affects the total loans advanced. This means that as the Central Bank lending rate to commercial banks increases, the Commercial Bank lending rate to the private sector increases and vice versa.
Ureteroscopic management of upper tract transitional cell carcinoma and ureteropelvic obstruction

Introduction: Technological advances have increased the application of the endoscopic management of upper tract transitional cell carcinoma (TCC) and ureteropelvic junction obstruction (UPJO). Materials and Methods: Published, peer-reviewed articles on endoscopic treatment of upper tract TCC and UPJO were identified using the MEDLINE database. Results: Although nephroureterectomy remains the gold standard for upper tract TCC treatment, low-grade, low-stage and small tumors, especially in patients with solitary kidneys or poor renal function can be managed with encouraging success rates, despite the considerable recurrence rate. Endoscopic alternatives to pyeloplasty for UPJO can be used especially in cases with absence of crossing vessels, stricture length less than 1.5 cm, severe hydronephrosis and renal function less than 30%. Conclusion: Proper patient selection is critical for the successful endoscopic management of treatment of upper tract TCC and UPJO.
Detection of peripheral blood plasma cells as a predictor of disease course in patients with smouldering multiple myeloma

SUMMARY. We evaluated the number and labelling index of circulating peripheral blood monoclonal plasma cells (PBPC) in 57 patients with newly diagnosed smouldering multiple myeloma (SMM) to determine if these measurements could distinguish SMM from active multiple myeloma (MM). The PBPC were detected by a sensitive slide‐based immunofluorescence procedure that identified PC by their morphology and monoclonal light chain staining. The presence of abnormal PBPC (defined as an increase in number or proliferative rate of circulating monoclonal plasma cells) was correlated with patient status at 6 and 12 months after testing. 16 of the 57 patients progressed within 12 months and 63% of these had abnormal PBPC. In contrast, only 10% (4/41) of those patients who remained stable had abnormal PBPC. The median time to progression for patients with abnormal PBPC was 0.75 years, compared to 2.5 years for those patients without abnormal PBPC (P < 0.01). The detection of PBPC is important and helps to identify patients with active MM when other parameters suggest SMM. The lack of abnormal PBPC suggests SMM, and these patients may have a stable course without the need for immediate chemotherapy.
Valosin-containing protein (VCP)–Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor *

Protein quality control (PQC) plays an important role in stemming neurodegenerative diseases and is essential for the growth of some cancers. Valosin-containing protein (VCP)/p97 plays a pivotal role in multiple PQC pathways by interacting with numerous adaptors that link VCP to specific PQC pathways and substrates and influence the post-translational modification state of substrates. However, our poor understanding of the specificity and architecture of the adaptors, and the dynamic properties of their interactions with VCP hinders our understanding of fundamental features of PQC and how modulation of VCP activity can best be exploited therapeutically. In this study we use multiple mass spectrometry-based proteomic approaches combined with biophysical studies to characterize the interaction of adaptors with VCP. Our results reveal that most VCP-adaptor interactions are characterized by rapid dynamics that in some cases are modulated by the VCP inhibitor NMS873. These findings have significant implications for both the regulation of VCP function and the impact of VCP inhibition on different VCP-adaptor complexes.
The Effect of Board Characteristics on Iraqi Banks Performance

This article presents evidence on the association between board characteristics and operating performance in banks using unbalanced panel data of 20 banks in Iraq over a ten-year period from 2005–2014. This relationship is estimated by using pooled OLS approach. The empirical results provide evidence supporting a positive board composition, board size and bank performance. Nevertheless, it is also noted that banks with high percentage of female in the board of director is one of the reasons to make down the bank performance in Iraq. Taken together, findings of this study recommend that banks seeking some improvement in their financial performance should constitute more non-executive directors, big-sized boards of directors, and consisted of few female directors in the board.
Automated geocoding of routinely collected health data in New South Wales.

Almost every record of an individual’s contact with the NSW health system contains some form of spatial information, whether a street address or postcode. This information can be used to assign a geocode to the record, which in turn can be used to examine the spatial distributions of disease and health service utilisation. This article describes a study that compares two different methods of geocoding addresses from routinely collected administrative health data to enable small area analysis.
Fast Deep Vehicle Detection in Aerial Images

Vehicle detection in aerial images is a crucial image processing step for many applications like screening of large areas. In recent years, several deep learning based frameworks have been proposed for object detection. However, these detectors were developed for datasets that considerably differ from aerial images. In this paper, we systematically investigate the potential of Fast R-CNN and Faster R-CNN for aerial images, which achieve top performing results on common detection benchmark datasets. Therefore, the applicability of 8 state-of-the-art object proposals methods used to generate a set of candidate regions and of both detectors is examined. Relevant adaptations of the object proposals methods are provided. To overcome shortcomings of the original approach in case of handling small instances, we further propose our own network that clearly outperforms state-of-the-art methods for vehicle detection in aerial images. All experiments are performed on two publicly available datasets to account for differing characteristics such as ground sampling distance, number of objects per image and varying backgrounds.
Magnetic sensors in inertial navigation system

The purpose of this paper is to present a inertial navigation system with an additional magnetic sensor to increase the accuracy of the guidance system. Thus we obtain a system that has less need of an external reference system for correction of internal reference system, this increasing its autonomy. It is implemented with a 8-bit microcontroller and the usual solid state sensors: acceleration, magnetic and gyroscope.
Corporate Accelerators As Recent Form Of Startup Engagement: The What, The Why, And The How

An increasing number of established companies have recently started to launch corporate accelerator programs to engage with entrepreneurial startups, making this a worldwide, cross-industrial phenomenon. Nevertheless, there is a lack of understanding of the various objectives and approaches adopted by companies. This article examines 13 in-depth case studies of corporate accelerator programs and is the first to empirically derive and discuss a typology for corporate accelerators, assessing objectives and design configurations. Thereby, the article contributes to the emerging discussion about corporate accelerators in corporate entrepreneurship literature. Moreover, the findings provide corporate managers with an understanding of corporate accelerators and guidance for how to make design choices for startup engagement programs.