Miracle-dz/UniFAR-FTUs huggingface dataset:
Differences in the Magnitude of Wave Reflection Account for Differential Effects of Amlodipine- Versus Atenolol-Based Regimens on Central Blood Pressure: An Anglo-Scandinavian Cardiac Outcome Trial Substudy

Antihypertensive agents may differ in their effects on central systolic blood pressure, and this may contribute to treatment-related differences in cardiovascular outcomes. In a substudy of the Anglo-Scandinavian Cardiac Outcome Trial, we investigated whether directly measured carotid systolic blood pressure differed between people randomized to amlodipine- and atenolol-based therapies and whether this is accounted for by differences in wave reflection patterns. Additional analysis was undertaken to establish whether differences in carotid systolic blood pressure predicted left ventricular mass, accounting for between-treatment differences in left ventricular mass index. Blood pressure and flow velocity were measured in the right carotid artery of 259 patients. Wave intensity analysis was used to separate and quantify forward and backward waves. Brachial blood pressure did not differ significantly between groups, but carotid systolic blood pressure (127 [12] versus 133 [15] mm Hg; P<0.001), the ratio of backward:forward pressure (0.48 [0.17] versus 0.53 [0.19]; P=0.01), and wave reflection index (19.8% [10.9%] versus 23.3% [13.3%]; P=0.02) were significantly lower in patients randomized to amlodipine-based therapy. Left ventricular mass index was also lower in this group, and adjustment for carotid blood pressure attenuated treatment differences to a greater extent than brachial blood pressure. Carotid systolic blood pressure was also a significant independent predictor of left ventricular mass index in a multivariate model. Carotid systolic blood pressure is lower in people randomized to amlodipine-based compared with atenolol-based treatment despite there being no significant difference in brachial blood pressure. This difference is attributable to a lesser magnitude of wave reflection in patients randomized to the amlodipine-based regimen.
Ceremonies Design for PKI's Hardware Security Modules

Ceremonies are a useful tool to HSMs in PKI environments. They state operational procedures and usage scenarios. Their correct construction can lead to a safer operation. This paper presents basic ceremony procedures to manage the life cycle of cryptographic keys and ideas of requirements needed to assure security throughout the usage of ceremonies in the context of an HSM It presents ceremonies to make the implementing the OpenHSM protocols. OpenHSM protocol operational establishing basic building blocks that can be used by any PKI application based in an HSM. Our main contributions are the re-usage of ceremony phases and a survey on formal methods to verify them.
The absence of position sense in the human eye

It has been widely held (e.g. Sherrington, 1918; Hoffmann, 1934, p. 28) that we have a sense of position of the eyeball which depends on afferent nerve fibres from the extraocular muscles. However, the experiments of Helmholtz (1867) indicate that such a position sense, if it exists, is not used to correct visual impressions when the eye is passively displaced. The following experiments, done on four subjects, show that the eye has no position sense.
on 5 ’-deoxyadenosylcobalamin and methylcobalamin as sources for Vitamin B 12 added as a nutritional substance in food supplements

The present opinion deals only with the safety and bioavailability of two particular sources of vitamin B12, intended for the general population, to be added in food supplements. While the safety of cobalamin itself, in terms of amounts that may be consumed, is outside the remit of this Panel, it is necessary for the evaluation of the sources to read across from the safety data on the vitamin, because the sources evaluated are vitamers of vitamin B12.
ON SUCCESSIVE GENERATIONS OF STREPTOKINASE BASED THROMBOLYTIC AGENTS Review Article

Thrombotic disorders and their consecutive medical consequences are now well-known in both developed and developing countries. Complications associated with these disorders are emerged as the main cause of mortality in the world and is caused due to the imbalance in the regular maintenance of the homeostasis between clot formation and clot dissolution. The effectiveness of thrombolytic therapy has accelerated the attention to be paid for it, at the part of doctors, physiologists, pharmacologists, chemists, biologists, and biotechnologists. This is clearly shown by the development of both new therapeutic methods and thrombolytic preparations. The latter area has been developing in several directions, majority of them focus on the chemical modification of plasminogen activators and the development of new mutant and hybrid protein derivatives through genetic engineering. Among all other thrombolytic agents, streptokinase (SK) is widely used as a thrombolytic agent in the treatment of acute myocardial infarction (AMI) following coronary thrombosis. This review deals with the detailed description of new generation streptokinase based thrombolytic agents their mode of action, structural modifications and current position of the drug in the clinical market.
State feedback control for formation keeping in elliptical orbits with unknown relative perturbations

This paper investigates the keeping control for satellite formations in elliptical orbits, in which the relative perturbations between the leader and followers are considered. Firstly, a Type-2 TSK fuzzy logic system (IT2TSKFLS) is adopted to describe the unknown relative perturbations. And the perturbations are estimated by using an adaptive algorithm which is proposed in this paper. Then, in order to achieve a high keeping accuracy, a sliding mode based state feedback controller is developed. The stability analysis is implemented by using Lyapunov theory. Simulation results are presented to demonstrate the effectiveness of the proposed control algorithm.
A Quest for Human and Mouse Embryonic Stem Cell-specific Proteins *S

Embryonic stem cells (ESCs) are of immense interest as they can proliferate indefinitely in vitro and give rise to any adult cell type, serving as a potentially unlimited source for tissue replacement in regenerative medicine. Extensive analyses of numerous human and mouse ESC lines have shown generic similarities and differences at both the transcriptional and functional level. However, comprehensive proteome analyses are missing or are restricted to mouse ESCs. Here we have used an extensive proteomic approach to search for ESC-specific proteins by analyzing the differential protein expression profiles of human and mouse ESCs and their differentiated derivatives. The data sets comprise 1,775 non-redundant proteins identified in human ESCs, 1,532 in differentiated human ESCs, 1,871 in mouse ESCs, and 1,552 in differentiated mouse ESCs with a false positive rate of <0.2%. Comparison of the data sets distinguished 191 proteins exclusively identified in both human and mouse ESCs but not in their differentiated derivatives. Besides well known ESC benchmarks, this subset included many uncharacterized proteins, some of which may be novel ESC-specific markers. To complement the mass spectrometric approach, differential expression of a selection of these proteins was confirmed by Western blotting, immunofluorescence confocal microscopy, and fluorescence-activated cell sorting. Additionally two other independently isolated and cultured human ESC lines as well as their differentiated derivatives were monitored for differential expression of selected proteins. Some of these proteins were identified exclusively in ESCs of all three human lines and may thus serve as generic ESC markers. Our wide scale proteomic approach enabled us to screen thousands of proteins rapidly and select putative ESC-associated proteins for further analysis. Validation by three independent conventional protein analysis techniques shows that our methodology is robust, provides an excellent tool to characterize ESCs at the protein level, and may disclose novel ESC-specific benchmarks.
Waveform-preserving blind estimation of multiple independent sources

The problem of blind estimation of source signals is to estimate the source signals without knowing the characteristics of the transmission channel. It is shown that the minimum-variance unbiased estimates can be obtained if and only if the transmission channel can be identified blindly. It is shown that the channel can be blindly identified if and only if there is not more than one Gaussian source. This condition suggests that waveform-preserving blind estimation can be achieved over a wide range of signal processing applications, including those cases in which the source signals have identical nonGaussian distributions. The constructive proof of the necessary and sufficient condition serves as a foundation for the development of waveform-preserving blind signal estimation algorithms. Examples are presented to demonstrate the applications of the theoretical results. >
GFDM - Generalized Frequency Division Multiplexing

This paper presents the GFDM system, a generalized digital multi-carrier transceiver concept. GFDM is based on traditional filter bank multi-branch multi- carrier concepts which are now implemented digitally. Our GFDM approach exhibits some attractive features which are of particular importance for scenarios exhibiting high degrees of spectrum fragmentation. Spectrum fragmentation is a typical technical challenge of digital dividend use cases, exploiting spectrum white spaces in the TV UHF bands which are located in close proximity to allocated spectrum. Specifically, the GFDM features are a lower PAPR compared to OFDM, a ultra-low out-of- band radiation due adjustable Tx-filtering and last but not least a block-based transmission using cyclic prefix insertion and efficient FFT-based equalization. GFDM enables frequency and time domain multi-user scheduling comparable to OFDM and provides an efficient alternative for white space aggregation even in heavily fragmented spectrum regions.
Gradient estimation in a color filter array image and its application to demosaicing

We propose a gradient estimation algorithm in a color filter array (CFA) image and apply it to demosaicing. Using directly computed ones, the proposed method estimates gradients, which cannot be computed directly from the CFA image. The proposed gradient estimation method is simple, improving the performance of existing demosaicing methods.
A FPGA implementation of JPEG baseline encoder for wearable devices

In this paper, an efficient field-programmable gate array (FPGA) implementation of the JPEG baseline image compression encoder is presented for wearable devices in health and wellness applications. In order to gain flexibility in developing FPGA-specific software and balance between real-time performance and resources utilization, A High Level Synthesis (HLS) tool is utilized in our system design. An optimized dataflow configuration with a padding scheme simplifies the timing control for data transfer. Our experiments with a system-on-chip multi-sensor system have verified our FPGA implementation with respect to real-time performance, computational efficiency, and FPGA resource utilization.
Beta-Blocker-Induced Psoriasis: A Rare Side Effect

Beta blockers are one of the oral agents shown to decrease cardiovascular morbidity and mortality rates in randomized, controlled trials, and hence, they are widely used for the management of many cardiovascular situations. In terms of side effects there are 3 major modes of action: (1) contraction of smooth muscles, particularly of bronchi with nonselective agents; (2) exaggerated cardiac effects; and (3) central nervous system effects. There are also some rare side effects of beta blockers, some of which are unpredictable, but the others are related to mode of action at the cellular level. Beta-blocking agents may cause psoriaform eruptions and worsen existing psoriasis. Psoriasis may be an inconvenient side effect of beta blockade. Herein, we report a case of beta-blocker-induced psoriasis.
Human versus HIV: round 2 defeat in AIDS vaccine development

On 21st September 2007, the worldwideHIV research community received a pressstatement via email from the US NationalInstitute of Allergy and Infectous Disease(NIAID) announcing that immuniza-tions of volunteers in a large, interna-tional HIV vaccine Phase IIb clinical trial,known as the STEP study, had been dis-continued
The Rationalization of the Organizational Meeting: Implications of Group Support Systems for Power, Symbolism and Face-Work

Current Group Support System (GSS) theory is heavily influenced by a rational model of human behavior, which in turn leads to some fundamental assumptions about what meetings are all about and what can be done to improve them. The purpose of this paper is to examine these fundamental assumptions, but from a perspective other than the more typical one of small-group processes and dynamics. Instead, we draw on organizational theories of power and politics, organizational culture and symbolism, and interactionism to provide new vantage points from which to examine these fundamental GSS objectives. Each of these perspectives represent fundamentally different philosophies on the nature and processes that characterize organizational meetings. From this theoretical triangulation, a much richer picture of organization meetings emerges. In particular, it becomes apparent that the rich shading and nuances of meaning that characterize organizational meetings are not adequately captured by a strictly small-group based, rational model of human behavior. To hope to understand how technology will change the dynamics of decisionmaking, hidden agendas, veiled threats, hidden meanings, the formation and disintegration of alliances, the shifting nattire of power and status, to name but a few, a theory base as rich as these dynamics will be needed.
Ion-trap tandem mass spectrometric analysis of squalene monohydroperoxide isomers in sunlight-exposed human skin Published, JLR Papers in Press, September 11, 2007.

We previously discovered that squalene monohydroperoxide (SQ-OOH) was produced on human forehead skin and suggested that skin squalene (SQ) may be the principal target lipid for oxidative stress (e.g., sunlight exposure). Because of its six double bonds, SQ peroxidation can yield various positional hydroperoxide isomers. However, the structural characterization of skin SQ-OOH isomers has never been reported. Here, we prepared pure SQ-OOH isomers and developed an analytical method for SQ-OOH isomers using a quadrupole/linear ion-trap mass spectrometer (QTRAP) MS/MS system. Collision-induced dissociation produced specific fragment ions for each SQ-OOH isomer, which permitted discrimination between SQ-OOH isomers by multiple reaction monitoring (MRM). When lipid extract from human forehead skin was subjected to LC-MS/MS with MRM, individual SQ-OOH isomers could be separated and detected with a sensitivity of 0.05 ng/injection. The total concentration of SQ-OOH isomers in forehead skin was ∼956 μg/g skin lipids, but it increased up to 2,760 μg/g skin lipids after 3 h of sunlight exposure. The LC-MS/MS method was useful for investigating the peroxidation mechanisms of SQ as well as SQ-OOH-mediated skin disorders.
POSTURAL DISHARMONY IN RELATION TO THE BACK PAIN AND PHYSIOTHERAPEUTIC REHABILITATION

Introduction: Postural attitude is putting the body at attention as an important factor in the prevention of spinal deformities axis and thus the back pains due to changes in articulacio sacroiliaca (ASI), lumbal syndrome (SL), cervical syndrome (SC) and others. Purpose: The purpose of this research is to determine the level of impact of spinal muscular misbalance that affects daily life activities, physiotherapeutic protocol according to Dr. MC Gill’s, and senso-motoric exercises to reduce the pain that backpack. In this material were included 43 patients, 13 males and 30 females aged 18 to 50 years old who were inculded in the second and third degree after completing a survey of ODI’s–the index of disability (Oswestry Disability Index). Results: The results obtained show that after the protocol of physiotherapeutic Dr. MC Gill’s, and senzoro-motor exercise significantly decrease pain in the back which confirmed the results of the questionnaire according to ODI, where it is seen that out of 30 patients with complaints of second-degree or 69.8%, and 13 patients or 30.2% that have been complaints of third degree with significant disorders of activity of daily life before rehabilitation treatment. The results obtained after three-month rehabilitation treatment according ODIT’s questionnaire (Oswestry Disability Index) show that 31 patients have complaints of first instance or 72.1%, then 9 patients have complaints or 20.9% of second level and 3 patients or 7.0% remained in the third degree of apparent disorder of daily life activity. Conclusion: From this we can highlight the misbalance of muscles of the body is one of the leading causes of back pain.
Lactobacillus reuteri Modulates Cytokines Production in Exhaled Breath Condensate of Children With Atopic Dermatitis

We measured the concentration of interferon-γ and interleukin-4 in the exhaled breath condensate of children with atopic and nonallergic dermatitis receiving a probiotic supplementation (Lactobacillus reuteri ATCC 55730) or placebo for 8 weeks. We demonstrated that the levels of these cytokines increased and decreased respectively only in atopic subjects receiving active treatment. Our data suggest that the oral administration of a specific probiotic strain in patients with atopic dermatitis can modulate in vivo the cytokine pattern at a different site from intestine.
Molecular staging of lung cancer: real-time polymerase chain reaction estimation of lymph node micrometastatic tumor cell burden in stage I non-small cell lung cancer--preliminary results of Cancer and Leukemia Group B Trial 9761.

OBJECTIVE The 5-year survival for patients with surgically resected stage I non-small cell lung cancer is only 60% to 70%, probably because of undetected systemic occult micrometastases. Detection of occult micrometastases in lymph nodes by reverse-transcriptase polymerase chain reaction for carcinoembryonic antigen messenger RNA in non-small cell lung cancer has not been reported. Detection of occult micrometastases by standard reverse-transcriptase polymerase chain reaction provides only yes or no answers about their presence, whereas quantitative real-time reverse-transcriptase polymerase chain reaction permits reproducible quantitation of target molecules. This study evaluated the ability of quantitative reverse-transcriptase polymerase chain reaction to quantitate lymph node occult metastases with carcinoembryonic antigen messenger RNA as a tumor marker. METHODS Standard reverse-transcriptase polymerase chain reaction and quantitative reverse-transcriptase polymerase chain reaction for carcinoembryonic antigen messenger RNA were performed on 232 lymph nodes from 53 patients with stage I disease (node negative according to histologic examination). Quantitative reverse-transcriptase polymerase chain reaction determined carcinoembryonic antigen messenger RNA quantity by detecting fluorescence increase at a threshold polymerase chain reaction cycle. Threshold polymerase chain reaction cycle values were correlated with standard curves created from serially diluted carcinoembryonic antigen-positive HTB-174 tumor cells to estimate the number of micrometastatic tumor cells in a lymph node. RESULTS Detection rates of occult metastases were similar for standard reverse-transcriptase polymerase chain reaction and quantitative reverse-transcriptase polymerase chain reaction at 38 of 232 (16.4 %) and 59 of 232 (25.4 %), respectively. Upstaging rates among 53 cases of stage I non-small cell lung cancer were also similar for standard reverse-transcriptase polymerase chain reaction and quantitative reverse-transcriptase polymerase chain reaction at 23 of 53 (43.4 %) and 30 of 53 (56.6%), respectively. Comparison of positive lymph node stations according to quantitative reverse-transcriptase polymerase chain reaction (threshold polymerase chain reaction cycle <45) with HTB-174 tumor cell standard curves yielded estimates of metastatic tumor cell burden of 1.07 x 10(3)to 3.24 x 10(5)cells per lymph node station (median 7190 tumor cells per lymph node station). CONCLUSIONS Standard and quantitative real-time reverse-transcriptase polymerase chain reaction for carcinoembryonic antigen detected occult metastases in patients with stage I non-small cell lung cancer at similar rates; both upstaged about 50% of cases. Quantitative reverse-transcriptase polymerase chain reaction allows estimation of the number of metastatic cells per lymph node, however, which potentially allows greater precision in predicting recurrence risk.
A wafer-level diamond bonding process to improve power handling capability of submillimeter-wave Schottky diode frequency multipliers

We have developed a robust wafer-level substrate bonding process that has allowed us to bond CVD diamond to GaAs membrane-based submillimeter-wave Schottky diode frequency multipliers. The high thermal conductivity of CVD diamond allows the chip to dissipate heat more efficiently thus increasing the power handling capability of the chips. This process has resulted in single-chip multiplier devices working in the submillimeter-wave range that can handle hundreds of milliwatts of input power. Output powers of 40 mW at 250 GHz and 27 mW at 300 GHz from a single chip have been demonstrated with this method. It is expected that by power combining these chips it is now possible to achieve a wideband 300 GHz signal with more than 100 mW of power. This represents a dramatic improvement in the current state of the art and allows one to begin realizing submillimeter-wave radar applications.
Quality of life in prostate cancer patients

Prostate cancer is the most common cancer in men and the second leading cause of cancer deaths in men. It affects middleaged and older men and usually has an indolent but progressive clinical course. Patients are often diagnosed when, because of age or other illnesses, they are less able to withstand disease-related morbidity. Further, for both localized and advanced disease they face a range of therapeutic options associated with troublesome side effects and functional impairments. These facts, coupled with recent intense media coverage, have raised public awareness of prostate cancer in general and focused much-needed attention on quality-of-life issues facing prostate cancer patients. The quality of life of men with prostate cancer has been studied less than that of patients with other neoplasms. As yet no comprehensive understanding exists of the physical, vocational, psychological, social, and sexual functioning in men with prostate cancer over the natural course of the disease. This report reviews current quality-oflife concepts in early and advanced prostate cancer, suggests how they may be integrated into patient care, and proposes relevant questions for research.