Miracle-dz/UniFAR-FTUs huggingface dataset:
Building Indigenous Australian research capacity

Abstract Objectives: To build individual Indigenous research capacity and strengthen the capability of health research programmes to be culturally and ethically inclusive of Indigenous Australians in public health research. Methods: In order to facilitate optimal participation and in recognition of the differing levels of research experience and knowledge held within this community of practice, an inclusive and culturally appropriate mixed methods approach with influences from action research and Indigenous research principles was undertaken. Results: Over the duration of the project, participants improved their research outcomes as measured by a range of factors including publications, completion of degrees and retention of project members. Conclusions: Provision of an Indigenous led, culturally appropriate system of infrastructure and support centred on capacity building is effective in strengthen the inclusion of Indigenous Australians in research.
Theo Labor Instit Strasb Spontaneous Mechanical Oscillations : Implications for Developing Organisms

Major transformations of cells during embryonic development are traditionally associatedwith theactivationor inhibition of genesandwithproteinmodifications. The contributions of mechanical properties intrinsic to the matter an organism is made of, however, are often overlooked. The emerging field “physics of living matter” is addressing active material properties of the cytoskeleton and tissues
Fluorine-18-fluoro-L-DOPA dosimetry with carbidopa pretreatment.

UNLABELLED This article presents dosimetry based on the measurement of fluoro-DOPA activity in major tissues and in the bladder contents in humans after oral pretreatment with 100 mg carbidopa. METHODS Bladder activity was measured continuously by external probe and calibrated using complete urine collections. Quantitative dynamic PET scans provided time-activity curves for the major organs. Bladder wall dosimetry was calculated using the methods of MIRD Pamphlet No. 14. Effective dose was calculated as described in ICRP Publication 60. RESULTS Mean absorbed dose to the bladder wall surface per unit administered activity was 0.150 mGy/MBq (0.556 rad/mCi) with the realistic void schedule used in our studies. The dose was 0.027 mGy/MBq (0.101 rad/mCi) to the kidneys, 0.0197 mGy/MBq (0.0728 rad/mCi) to the pancreas, and 0.0186 mGy/MBq (0.0688 rad/mCi) to the uterus. Absorbed doses to other organs were an order of magnitude or more lower than the bladder, 0.009-0.015 mGy/MBq. The effective dose per unit administered activity was 0.0199 mSv/MBq (0.0735 rem/mCi.) CONCLUSION Urinary excretion of fluoro-DOPA was altered significantly by pretreatment with carbidopa. In general, any manipulation of tracer metabolism in the body should be expected to produce changes in biodistribution and dosimetry. The largest radiation dose was to the bladder wall, for which our estimate was one-fifth of that from the original report. The methods used reflect realistic urinary physiology and typical use of this tracer. The principles of MIRD Pamphlet No. 14 should be used in planning studies using tracers excreted in the urine to minimize the absorbed dose.
Developing Knowledge Management Capabilities: A Structured Approach

Purpose – Knowledge management (KM) needs a systematic approach to develop capabilities which accelerate the evolution of knowledge into a key organizational resource. This paper aims to address this issue.Design/methodology/approach – This paper reports the empirical findings of a case study offering insights into the infrastructure and process capabilities required to provide knowledge support for organizational routines and activities.Findings – It also presents a four‐stage framework that helps to make sense of the development of capabilities during the implementation of KM initiatives.Practical implications – The research moves KM capability development from being a mere concept to being a clearly articulated set of stages, which underpin organizational growth.Originality/value – As above, the research moves KM capability development from being a mere concept to being a clearly articulated set of stages, which underpin organizational growth.
An approximation for the optimum binary integration threshold for Swerling II targets

An approximation is derived for the optimum M for M-out-of-N binary integration applied to Swerling II targets. This optimum M minimizes the required signal-to-noise ratio for given probabilities of detection and false alarm and a given N. The approximation is valid for probabilities of detection in the range of 0.1 to 0.95 and for typical probabilities of false alarm. Examples of the accuracy of this approximation are given.
RECENT ADVANCES IN THE TREATMENT OF CHILDHOOD BRAIN TUMORS

Pediatric brain tumors are the commonest cause of cancer-related death in children. The last four decades have seen only a 35% increase in 5-year survival rate of children with these tumors. The therapeutic successes achieved are due to advances in neuroimaging, surgical techniques, radiotherapy, and induction of newer chemotherapeutic agents along with molecular targeted therapy. Neuroimaging advances include the use of MRA, MRS, DSA, and PET scans. With the use of stereotactic surgery, intraoperative mapping, and imaging, surgical resection has improved with significant decrease in morbidity. A major development has been the use of precision guided radiotherapy utilizing technologies like 3D-CRT, SRS, and IMRT, thereby decreasing radiation to normal tissues. Induction of newer drugs and high-dose chemotherapy with peripheral stem cell support has improved survival and delayed radiation in younger children and infants with brain tumors. Intense ongoing research is profiling novel molecular targets for therapeutic intervention. Newer therapeutic strategies like blood brain barrier disruption, immunotherapy, and gene therapy are in clinical trials. This review article intends to give the reader an overview of current therapeutic strategies and research involved in the treatment of children with brain tumors.
Deletion of the Chloride Transporter Slc26a7 Causes Distal Renal Tubular Acidosis and Impairs Gastric Acid Secretion*

SLC26A7 (human)/Slc26a7 (mouse) is a recently identified chloride-base exchanger and/or chloride transporter that is expressed on the basolateral membrane of acid-secreting cells in the renal outer medullary collecting duct (OMCD) and in gastric parietal cells. Here, we show that mice with genetic deletion of Slc26a7 expression develop distal renal tubular acidosis, as manifested by metabolic acidosis and alkaline urine pH. In the kidney, basolateral Cl−/HCO3− exchange activity in acid-secreting intercalated cells in the OMCD was significantly decreased in hypertonic medium (a normal milieu for the medulla) but was reduced only mildly in isotonic medium. Changing from a hypertonic to isotonic medium (relative hypotonicity) decreased the membrane abundance of Slc26a7 in kidney cells in vivo and in vitro. In the stomach, stimulated acid secretion was significantly impaired in isolated gastric mucosa and in the intact organ. We propose that SLC26A7 dysfunction should be investigated as a potential cause of unexplained distal renal tubular acidosis or decreased gastric acid secretion in humans.
Upper Echelons and Executive Profiles in the Construction Value Chain: Evidence from Italy

Which executive profiles currently govern the construction value chain? Addressing this lively research question is the key point of our article and it appears central to scholars, practitioners, and policymakers interested in project management in general, and construction and real estate in particular. For this reason, we draw from Upper Echelons Theory in studying the executive profiles of 109 important firms currently active in Italy. Our statistical analysis shows that, although homogeneity substantially regards the executive's gender, age, and level of education, heterogeneity is associated more with his or her functional background. We thus prospect some conceptual and methodological avenues for further analyses in this challenging area of research.
Experimental Investigations on the Frequency- and Temperature-Dependent Dielectric Material Properties of Soil

Frequency- and temperature-dependent complex permittivity or conductivity of a silty clay loam were examined in a broad saturation and porosity range with network analyzer technique (1 MHz-10 GHz, 5 °C-40 °C, coaxial transmission line and open ended coaxial cells). An advanced mixture model based on the well-known Lichtenecker-Rother model (ALRM) was developed and used to parameterize complex permittivity or conductivity at a measurement frequency of 1 GHz under consideration of a dependence of the so-called structure parameter as well as the apparent pore water conductivity on saturation and porosity. The ALRM is compared with frequently applied mixture models: complex refractive index model, Looyenga-Landau-Lifschitz model, Bruggeman-Hanai-Sen model, and Maxwell-Garnet model as well as empirical calibration functions. Comparison of ALRM applied to the investigated frequency and temperature range with sophisticated broadband relaxation models indicates the potential and the limitation to predict the high-frequency electromagnetic material properties.
A multi-channel low-power system-on-chip for single-unit recording and narrowband wireless transmission of neural signal

This paper reports a multi-channel neural recording system-on-chip (SoC) with digital data compression and wireless telemetry. The circuit consists of a 16 amplifiers, an analog time division multiplexer, an 8-bit SAR AD converter, a digital signal processor (DSP) and a wireless narrowband 400-MHz binary FSK transmitter. Even though only 16 amplifiers are present in our current die version, the whole system is designed to work with 64 channels demonstrating the feasibility of a digital processing and narrowband wireless transmission of 64 neural recording channels. A digital data compression, based on the detection of action potentials and storage of correspondent waveforms, allows the use of a 1.25-Mbit/s binary FSK wireless transmission. This moderate bit-rate and a low frequency deviation, Manchester-coded modulation are crucial for exploiting a narrowband wireless link and an efficient embeddable antenna. The chip is realized in a 0.35- εm CMOS process with a power consumption of 105 εW per channel (269 εW per channel with an extended transmission range of 4 m) and an area of 3.1 × 2.7 mm2. The transmitted signal is captured by a digital TV tuner and demodulated by a wideband phase-locked loop (PLL), and then sent to a PC via an FPGA module. The system has been tested for electrical specifications and its functionality verified in in-vivo neural recording experiments.
ASYMMETRIC PRICE INCREASE IN CRITICAL LOSS ANALYSIS: A REPLY TO LANGENFELD AND LI

James Langenfeld and Wenqing Li claim that the market delineating criterion of Oystein Daljord, Lars Sorgard, and Oyvind Thomassen for an asymmetric small, but significant and nontransitory increase in price (SSNIP) is logically inconsistent and tends to define too broad antitrust markets. We show that these claims are false.
Women Investors' Perception Towards Investment-An Empirical Study

The hand that rocks the cradle rules the world's is a popular saying about women. Savings is a habit specially embodied to women. Even in the past, when women mainly depend on their spouse income, they used to save to meet emergencies as well as for future activities. In those days, women did not have any awareness about various investment outlets. But as time passed, the scenario has totally changed.
The role of Ca2+ feedback in shaping InsP3‐evoked Ca2+ signals in mouse pancreatic acinar cells

1 Cytosolic Ca2+ has been proposed to act as both a positive and a negative feedback signal on the inositol trisphosphate (InsP3) receptor. However, it is unclear how this might affect the Ca2+ response in vivo. 2 Mouse pancreatic acinar cells were whole‐cell patch clamped to record the Ca2+‐dependent chloride (Cl(Ca)) current spikes and imaged to record the cytosolic Ca2+ spikes elicited by the injection of Ins(2,4,5)P3. Increasing concentrations of Ca2+ buffer (up to 200 μm EGTA or BAPTA) were associated with the appearance of steps in the current activation phase and a prevalence of smaller‐amplitude Cl(Ca) spikes. Imaging experiments showed that with increased buffer the secretory pole cytosolic Ca2+ signal became fragmented and spatially discrete Ca2+ release events were observed. 3 At higher buffer concentrations (200‐500 μm), increasing concentrations of EGTA increased spike frequency and reduced spike amplitude. In contrast, BAPTA decreased spike frequency and maintained large spike amplitudes. 4 We conclude that, during InsP3‐evoked spiking, long‐range Ca2+ feedback (∼2–4 μm) shapes the rising phase of the Ca2+ signal by acting to co‐ordinate discrete Ca2+ release events and short‐range (∼40 nm) Ca2+ feedback acts to inhibit further Ca2+ release.
Longitudinal trends in diet and effects of sex, race, and education on dietary quality score change: the Coronary Artery Risk Development in Young Adults study.

BACKGROUND The food supply and dietary preferences have changed in recent decades. OBJECTIVE We studied time- and age-related individual and population-wide changes in a dietary quality score and food groups during 1985-2006. DESIGN The Coronary Artery Risk Development in Young Adults (CARDIA) study of 5115 black and white men and women [aged 18-30 y at year 0 (1985-1986)] assessed diet at examinations at study years 0, 7 (1992-1993), and 20 (2005-2006). The dietary quality score, which was validated by its inverse association with cardiovascular disease risk, summed 46 food groups rated by investigators as positive or negative on the basis of hypothesized health effects. We used repeated-measures regression to estimate time-specific mean diet scores and servings per day of food groups. RESULTS In 2652 participants with all 3 diet assessments, the mean (±SD) dietary quality score increased from 64.1 ± 13.0 at year 0 to 71.1 ± 12.6 at year 20, which was mostly attributable to increased age. However, the secular trend, which was estimated from differences of dietary quality scores across time at a fixed age (age-matched time trend) decreased. The diet score was higher in whites than in blacks and in women than in men and increased with education, but demographic gaps in the score narrowed over 20 y. There tended to be increases in positively rated food groups and decreases in negatively rated food groups, which were generally similar in direction across demographic groups. CONCLUSIONS The CARDIA study showed many age-related, desirable changes in food intake over 20 y of observation, despite a secular trend toward a lower diet quality. Nevertheless, demographic disparities in diet persist.
Emergence of cultural intelligence and global mindset capital: a multilevel model

The purpose of this paper is to establish under which conditions researchers should use the constructs cultural intelligence (CQ) and global mindset (GM). The authors further seek to understand the process through which these constructs emerge to a higher level and link unit-level knowledge, skills and abilities (KSAs) capital to pertinent firm-level outcomes. ,This paper is a conceptual study with a multilevel model. ,This paper differentiates two similar lines of research occurring concordantly on the CQ and GM constructs. Next, the authors develop a multilevel model to better understand the process through which CQ and GM emerge at higher levels and their underlying mechanisms. Finally, this paper adds meaning to the firm-level KSAs by linking firm-level KSAs capital to pertinent firm-level outcomes. ,The conclusion implies that researchers should use CQ when the context is focused on interpersonal outcomes and GM when focused on strategic outcomes. The multilevel model is a useful tool for scholars to select which rubric to use in future studies that have international managers as the subjects. The authors argue that if the scholar is interested in an individual’s ability to craft policy and implement strategy, then GM may be more parsimonious than CQ. On the other hand, if the focus is on leadership, human resources or any other relationship dependent outcome, then CQ will provide a more robust measure. ,For practitioners, this study provides a useful tool for managers to improve individual-level commitment by selecting and training individuals high in CQ. On the other hand, if the desired outcome is firm-level sales or performance, the focus should be on targeting individuals high in GM. ,This is the first theoretical paper to examine how CQ and GM emerge to the firm level and describe when to use each measure.
Measuring Interdisciplinarity Using Text

This article presents a new, text-based measure of interdisciplinarity. The author compares the text of a scholar’s publications with text from multiple disciplines and measures the extent to which a scholar’s work integrates language from distal and proximate disciplines. The measure is tested on all faculty members employed at Stanford University between 1993 and 2008. Comparisons among text, citation, and coauthorship measures of interdisciplinarity; measures of disciplinarity; and other variables provide validity evidence for the measure. This text-based measure of interdisciplinarity offers new opportunities for data analysis, especially for unstructured text and within book-centric fields such as the humanities.
Loughborough University Institutional Repository An informational stair climbing intervention with greater e ects in overweight pedestrians

Previous interventions have successfully increased levels of stair climbing in publicaccess settings (e.g. malls). This study used robust methods to establish the magnitude of intervention effects amongst a specific target group – the overweight. Ascending stair/escalator users (N=20,807) were observed in a mall. A two-week baseline was followed by a five-week intervention in which message banners, promoting stair climbing, were attached to the stair-risers. Standardised silhouettes were used to code individuals as normal/overweight. Logistic regression analyses were conducted with stair/escalator choice as the outcome variable and weight status entered as a moderator alongside condition, gender, ethnicity and ‘pedestrian traffic volume’. Overall, the intervention significantly increased the rate of stair climbing (odds ratio [OR]=1.28, 95% confidence intervals [CI]=1.08-1.53), with the effects sustained over five weeks. There were differential effects between weight categories, with greater increases in overweight (OR=1.95, CI=1.34-2.83) versus normal weight individuals (OR=1.29, CI=1.09-1.53). In conclusion, message prompts produced larger effects amongst overweight individuals, who could benefit most from stair climbing. The public health value of these interventions may, therefore, be greater than realised. The heightened effects amongst the overweight were likely due to the salience of the current message, which linked stair climbing with the target of weight control.
Morphology and Phylogenetic Analyses of Three Novel Naegleria Isolated from Freshwaters on Jeju Island, Korea, During the Winter Period

The genus Naegleria is one of the best known heterolobosean groups, and is the causative agent of primary amoebic meningoencephalitis. This group is rarely studied in temperate regions during winter. Here, three novel Naegleria were isolated from freshwaters on Jeju Island, Korea, during winter. Two isolates were amoeboflagellates, and one of the three amoebae did not undergo enflagellation. All amoebae had eruptive pseudopodia, and the layer of refractile granules around a large nucleus. They formed a cyst with ~2 pores in the cyst stage. The amoeboflagellate form had two flagella and no division in the flagellate stage, and no cytostome. These features are very similar to typical Naegleria. Furthermore, our isolates were able to grow at > 30 °C, suggesting that they had different thermophilicity from Naegleria in polar regions. All amoebae were largely encysted at 5 or 10 °C, indicating that they were likely encysted during winter. Based on the 18S rRNA gene and the ITS1‐5.8S rRNA gene‐ITS2 sequences, the phylogenetic analyses consistently revealed that the isolates are members of the Naegleria group. However, the isolates differ from other species in both phylogenetic trees. Thus, Naegleria in cold habitats appeared to have a high degree of novelty, but their thermophilicity may be dependent on locality.
Applicability of Ambler's risk score to patients who have undergone valve replacement with bovine pericardial bioprosthesis.

OBJECTIVES This study aims to verify the applicability of Ambler's risk score to patients who have undergone implantation of bovine pericardial bioprosthesis at the Instituto de Cardiologia do RGS/FCU. This study also aims to quantify the risk factors. METHODS Retrospective study with 703 patients who had undergone implantation of bovine pericardial bioprosthesis between 1991 and 2005 at the Instituto de Cardiologia do RS. Aortic implant occurred in 392 patients, mitral in 250 and combined in 61. Primary outcome was hospital mortality. Characteristics used to estimate risk were: gender, age, body mass index (BMI), NYHA functional class, left ventricular ejection fraction, valvular lesions, systemic arterial hypertension, diabetes mellitus, renal function, cardiac rhythm, previous cardiac operations, and surgical priority. Univariate and multivariate logistic regression was used to quantify preponderant risk factors by the odds-ratio (OR). RESULTS The mortality rate was 14.3%, which was higher than the estimated mortality rate (3%, according to Ambler's mean score of 6, (p<0.01)). Patients who died presented a mean score of 8.26, which was higher than the survivors' average score of 5.68. Characteristics of increased risk were emergency surgery (OR=10.87), dialysis (OR=6.10), and age higher than 80 years (OR=6.10). Our sample indicates an area under the ROC curve of 72.9% (accepted value > 70%). CONCLUSION The mortality predicted in Ambler's score was not reproduced in the observed results. However, the ROC curve provides evidence that this model is applicable. Preponderant risk factors were individualizated.
3-D Sequential Integration: A Key Enabling Technology for Heterogeneous Co-Integration of New Function With CMOS

3-D sequential integration stands out from other 3-D schemes as it enables the full use of the third dimension. Indeed, in this approach, 3-D contact density matches with the transistor scale. In this paper, we report on the main advances enabling the demonstration of functional and performant stacked CMOS-FETs; i.e., wafer bonding, low temperature processes (<;650°C) and salicide stabilization achievements. This integration scheme enables fine grain partitioning and thus a gain in performance versus cost ratio linked to separation of heterogeneous technologies on distinct levels. In this work, we will detail examples taking advantage of the unique 3-D contact pitch achieved with sequential 3-D.
Hippocampal sclerosis is a progressive disorder: A longitudinal volumetric MRI study

Twelve patients with refractory temporal lobe epilepsy and unilateral hippocampal sclerosis had repeat volumetric magnetic resonance imaging scans after a mean of 3.4 years to determine whether progressive hippocampal volume loss occurred. Seizure‐free patients showed no change in hippocampal volume. Patients with continuing seizures had a decline in ipsilateral hippocampal volume that correlated with seizure frequency. Patients with medically refractory temporal lobe epilepsy and unilateral hippocampal sclerosis have progressive hippocampal atrophy. Ann Neurol 2003;53:413–416