Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunohistochemistry of adnexal neoplasms

The immunohistoehemieal examination of adnexal neoplastns is an area of eonsidetable pertinenee to the dertnatopathologist. This area is rapidly expanding as new polyelonal and monoelonal antibodies are being inttoduced which have specificities for various parts of the eutaneous adnexa. These antihodies may be used to study the histogenesis of adnexal neoplasms and to identify and categorize poorly differetitiated neoplastns. At present, several useful atitibodies exist which identify epitopes in ecerine and apocrine glands; antibodies of diagnostic relevance directed against antigens in sebaceous gland and pilar unit are not yet available. Antigens that have been studied in adnexal structures are; 1) earcinoembryonic antigen (CEA); 2) SI00 protein; 3) the blood group substances. A, B, and H; 4) beta 2-microglobulin; 5) casein; 6) prekeratins; 7) a variety of antigens identified by tnonoclonal antibodies.
Planar Artificial Transmission Lines Loading for Miniturization of RFID Printed Quasi-Yagi Antenna

A compact omnidirectional printed quasi-Yagi antenna for RFID reader application is presented. To reduce the size of the antenna, the radiating elements of the quasi-Yagi antenna are replaced by artificial transmission lines (ATLs). The proposed antenna that operates at 915 MHz has a substrate size of 52×77mm2, which shows more than 76.24% size reduction in comparison to the previously reported compact Yagi antenna. At the center frequency, the antenna has an input impedance of 46.66-j4.27 Ω, radiation efficiency of 98.2%, and a gain of 1.84 dBi. The experimental data are in good agreement with the simulation results.
The influence of the electronic specific heat on swift heavy ion irradiation simulations of silicon

The swift heavy ion (SHI) irradiation of materials is often modelled using the two-temperature model. While the model has been successful in describing SHI damage in metals, it fails to account for the presence of a bandgap in semiconductors and insulators. Here we explore the potential to overcome this limitation by explicitly incorporating the influence of the bandgap in the parameterisation of the electronic specific heat for Si. The specific heat as a function of electronic temperature is calculated using finite temperature density functional theory with three different exchange correlation functionals, each with a characteristic bandgap. These electronic temperature dependent specific heats are employed with two-temperature molecular dynamics to model ion track creation in Si. The results obtained using a specific heat derived from density functional theory showed dramatically reduced defect creation compared to models that used the free electron gas specific heat. As a consequence, the track radii are smaller and in much better agreement with experimental observations. We also observe a correlation between the width of the band gap and the track radius, arising due to the variation in the temperature dependence of the electronic specific heat.
Withdrawal of life support in the neurological intensive care unit

Objective: To describe the frequency and clinical course of terminal extubation in the neurological intensive care unit, to identify factors that influence the decision to withdraw life support, and to evaluate the experiences of surrogate decision-makers. Background: The right of patients to refuse life-prolonging treatment is widely accepted. However, it is unknown how frequently critically ill neurologic patients are removed from life support, and practice guidelines for withdrawing mechanical ventilation remain poorly defined. Methods: We reviewed the medical records of all patients cared for by the Columbia–Presbyterian neurocritical care service over a 3-year period who died, and identified a subgroup of non–brain-dead patients who were terminally extubated. We retrospectively analyzed the clinical course of these patients and interviewed their surrogate decision-makers. Results: Of 74 non–brain-dead patients, 32 (43%) were terminally extubated. Hispanic and white patients were more likely to be extubated than were African American patients (p = 0.02). The median duration of survival after extubation was 7.5 hours; 25% died within 1 hour, and 69% within 24 hours. Depth of coma did not predict the duration of survival after extubation. The most frequent signs after extubation were agonal or labored breathing (59%) and tachypnea (34%). Morphine or fentanyl was given to relieve respiratory distress in 68% of cases; the average dose of morphine was 6.3 mg/hour (range 2.5 to 20 mg/hour). In a structured interview of 24 surrogate decision-makers, 88% were satisfied or very satisfied with the overall process, and 75% felt the patient suffered minimally before death; all but one (96%) said that they would repeat the decision to withdraw life support. Conclusions: Forty-three percent of our non–brain-dead patients who died were terminally extubated. The duration of survival after extubation exceeded 24 hours in one third, and was not predicted by level of consciousness. Two thirds of patients were treated with opioids for agonal respiratory distress. Most surrogate decision-makers were comfortable and satisfied with the process of withdrawing care.
Wies procedure combined with anterior lamellar recession in the management of cicatricial entropion of the upper eyelid

Purpose: To evaluate the efficacy of the Wies procedure combined with anterior lamellar recession in the management of cicatricial entropion of the upper eyelid. Patients and methods: Nineteen patients (24 upper lids) with severe cicatricial entropion, trichiasis, and tarsal shortening were included in this study. Previous Snellen’s operation was recorded in 6 patients (8 eyelids). All cases underwent anterior lamellar recession and wies procedure. Results: No residual entropion (no lash-cornea touch) was recorded in all lids (100%). All cases developed postoperative edema that subsided gradually within one week. Over correction occurred in 2 lids (8.3%), and three eyelids developed infection (12.5%), which healed in few days after antibiotic therapy. The mean follow up was 9 months (range; 6 to12 months). Conclusion: Wies procedure combined with anterior lamellar recession in the management of cicatricial entropion of the upper eyelid are effective especially for recurrent cases and short tarsus; no lid shortening developed postoperatively, and gave cosmetically accepted results.
Is there an influence of X‐chromosomal imprinting on the phenotype in Klinefelter syndrome? A clinical and molecular genetic study of 61 cases

Studies on Turner syndrome suggested the presence of X‐chromosomal‐imprinted genes involved in social and verbal cognition. Imprinted genes on autosomes were shown to affect growth. Could imprinting of such genes on the X chromosome also influence psychomotor development and growth in men with Klinefelter syndrome (KS), who have a supernumerary X? We recorded anthropometric and psychomotor development parameters for 61 males with KS (age range 2–56 years). In 54 cases, we were able to assess intelligence quotient (IQ) and found that impaired speech – and motor developmental problems were reported significantly more often in the paternal X – than in the maternal X group (P = 0.02). We found some significant (P < 0.05) increased body size parameters in the paternal X group, which concurs with data reporting a growth promoting influence of paternally derived genes. Our results suggest X‐chromosomal imprinting occurs in males with KS.
Planar Fully depleted SOI technology: A powerful architecture for the 20nm node and beyond

Recent device developments and achievements have demonstrated that planar undoped channel Fully depleted SOI devices are becoming a serious alternative to Bulk technologies for 20nm node and below. We have proven this planar option to be easier to integrate than the non planar devices like FinFET. This paper gives an overview of the main advantages provided by this technology, as well as the key challenges that need to be addressed. Electrostatic integrity, drivability, within wafer variability and scalability are addressed through silicon data (down to 18nm gate length) and TCAD analyses. Solutions to the Multiple VT challenges and non logic devices (ESD, I/Os) are also reported.
Real‐time diffusion‐perfusion mismatch analysis in acute stroke

Diffusion‐perfusion mismatch can be used to identify acute stroke patients that could benefit from reperfusion therapies. Early assessment of the mismatch facilitates necessary diagnosis and treatment decisions in acute stroke. We developed the RApid processing of PerfusIon and Diffusion (RAPID) for unsupervised, fully automated processing of perfusion and diffusion data for the purpose of expedited routine clinical assessment. The RAPID system computes quantitative perfusion maps (cerebral blood volume, CBV; cerebral blood flow, CBF; mean transit time, MTT; and the time until the residue function reaches its peak, Tmax) using deconvolution of tissue and arterial signals. Diffusion‐weighted imaging/perfusion‐weighted imaging (DWI/PWI) mismatch is automatically determined using infarct core segmentation of ADC maps and perfusion deficits segmented from Tmax maps. The performance of RAPID was evaluated on 63 acute stroke cases, in which diffusion and perfusion lesion volumes were outlined by both a human reader and the RAPID system. The correlation of outlined lesion volumes obtained from both methods was r2 = 0.99 for DWI and r2 = 0.96 for PWI. For mismatch identification, RAPID showed 100% sensitivity and 91% specificity. The mismatch information is made available on the hospital's PACS within 5–7 min. Results indicate that the automated system is sufficiently accurate and fast enough to be used for routine care as well as in clinical trials. J. Magn. Reson. Imaging 2010;32:1024–1037. © 2010 Wiley‐Liss, Inc.
The Antimicrobial Peptides P-113Du and P-113Tri Function against Candida albicans

ABSTRACT Two antimicrobial P-113 peptide derivatives, P-113Du and P-113Tri, were investigated in this study. Notably, P-113Du and P-113Tri contained significant fractions of α-helix conformation and were less sensitive to high salt and low pH than P-113. Moreover, compared to P-113, these peptides exhibited increased antifungal activity against planktonic cells, biofilm cells, and clinical isolates of Candida albicans and non-albicans Candida spp. These results suggest that P-113Du and P-113Tri are promising candidates for development as novel antifungal agents.
High-Throughput Screening AlphaScreen Assay for Identification of Small-Molecule Inhibitors of Ubiquitin E 3 Ligase SCFSkp 2-Cks 1

Decreased levels of cell cycle inhibitor p27 due to excessive degradation occur in a variety of aggressive human tumors. Since reduced p27 expression has been associated with a poor prognosis in many human cancers and resistance to certain antitumor therapies, elevation of p27 expression could improve prognosis and prevent excessive cell proliferation. SCF is one of the major ubiquitin E3 ligases responsible for degradation of p27. Ubiquitination of p27 also requires a small adaptor protein, Cks1, which facilitates substrate recruitment by bridging the interaction between Skp2 and p27. It has been shown previously that a direct interaction between Cks1 and Skp2 is required for p27 degradation. Accordingly, perturbation of the Skp2-Cks1 interaction may represent an attractive target for pharmacological intervention. Here we describe a high-throughput AlphaScreen assay for discovering small-molecule inhibitors of the Skp2-Cks1 protein-protein interaction in vitro. Two compounds (NSC689857 and NSC681152) were identified and validated through a structure-activity relationship analysis. Both compounds were also shown to inhibit p27 ubiquitination in vitro. These studies demonstrate that disruption of the Skp2-Cks1 interaction provides a viable strategy to prevent p27 ubiquitination and may potentially be useful for the control of excessive degradation of this cell cycle inhibitor in tumor cells.
Optical Biopsy of Human Skin - A Tool for Cutaneous Tumours' Diagnosis

A short review of the recent status of optical biopsy of human skin as a tool for cutaneous tumour detection will be presented. Basically laser- and light- induced fluorescence and diffuse reflectance techniques incorporated in so called "optical biopsy" technique used for skin tissue analysis will be described and some original results and findings from our own investigations will be commented as well. Fluorescence spectroscopy gives information mainly about changes in the biochemical content, and diffuse reflectance about morphological changes and pigments' concentrations in the human skin. Both techniques are applied separately and as a common tool for early skin cancer diagnosis, give high accuracy and objective diagnosis, applicable into the clinical practice. Skin optical biopsy diagnostic clinical trial is currently under implementation in the frames of University Hospital "Tsaritsa Yoanna - ISUL" and with broadening of the database with fluorescence and reflectance spectra of major skin benign and malignant pathologies we expect to receive objective tool for detection and evaluation of skin lesion type, which could become a basis for reliable system for skin cancer detection. Optical biopsy system is developed in the frames of Institute of Electronics, Bulgarian Academy of Sciences, and consists of autofluorescence and diffuse reflectance channels for early skin tumour detection. Fibro-optical probe allows receiving of noninvasive spectral information for the tissues' condition, which allows making highly-sensitive diagnosis of tissues in real time.
Assessment of a condition-specific quality-of-life measure for patients with developmentally absent teeth: validity and reliability testing.

OBJECTIVES This article describes the process of validity and reliability testing of a condition-specific quality-of-life measure for patients with hypodontia presenting for orthodontic treatment. The development of the instrument is described in a previous article. SETTING AND SAMPLE POPULATION Royal Devon and Exeter NHS Foundation Trust & Musgrove Park Hospital, Taunton. MATERIALS AND METHODS The child perception questionnaire was used as a standard against which to test criterion validity. The Bland and Altman method was used to check agreement between the two questionnaires. Construct validity was tested using principal component analysis on the four sections of the questionnaire. Test-retest reliability was tested using intraclass correlation coefficient and Bland and Altman method. Cronbach's alpha was used to test internal consistency reliability. RESULTS Overall the questionnaire showed good reliability, criterion and construct validity. This together with previous evidence of good face and content validity suggests that the instrument may prove useful in clinical practice and further research. CONCLUSIONS This study has demonstrated that the newly developed condition-specific quality-of-life questionnaire is both valid and reliable for use in young patients with hypodontia.
APPLYING COPULA FUNCTION TO RISK MANAGEMENT

This paper is part of the author’s Ph. D. Thesis “Extreme Value Theory and coherent risk measures: applications to risk management”. The copula function describes the dependence structure of a multivariate random variable. In this paper, it is used as a practical and flexible instrument to generate Monte Carlo scenarios of risk factor returns. These risk factors affect the value of a credit or market portfolio. In fact, many of the models commonly used assume a multinormal distribution of such risk factor returns (or log-returns). This hypothesis underestimates the probability that a catastrophic event, such as a simultaneous slump of equity prices or the joint default of several counterparties in a credit portfolio, might occur. This kind of event worries both risk managers and supervisors. Our goal is to show that the use of a copula function different from the Gaussian copula can model such extreme events effectively.
Two-Photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement

Small molecule therapeutic drugs must reach their intended cellular targets (pharmacokinetics) and engage them to modulate therapeutic effects (pharmacodynamics). These processes are often difficult to measure in vivo due to their complexities and occurrence within single cells. It has been particularly difficult to directly measure cellular drug target binding. Fluorescence polarization is commonly used in pharmacological screening assays to measure drug-protein or protein-protein interactions. We hypothesized that fluorescence polarization imaging could be adapted and used with fluorescently labeled drugs to measure drug target engagement in vivo . Here, we summarize recent results using two photon fluorescence anisotropy microscopy. Our imaging technique offers quantitative pharmacological binding information of diverse molecular interactions at the microscopic level, differentiating between bound, and unbound states. Used in combination with other recent advances in the development of novel fluorescently labeled drugs, we expect that the described imaging modality will provide a window into the distribution and efficacy of drugs in real time and in vivo at the cellular and subcellular level.
An Empirical Study on the Usage of SQL Execution Traces for Program Comprehension

Several studies have investigated dynamic analysis in the context of software maintenance and evolution, and most of them confirmed the positive impact of such analysis on program comprehension tasks. In this paper, we focus on the understanding of the database access behavior of a program, which has become an important (yet largely ignored) aspect of program comprehension. We empirically assess how developers/students are (not) able to understand interactions between the database and the application program. To this end, we used DAViS, a tool for Dynamic Analysis and Visualization of SQL execution traces. We present a controlled experiment that quantitatively evaluates to what extent DAViS can influence program comprehension in terms of duration and correctness of the tasks. The results of the study indicate that DAViS does reduce the response time and increases the correctness (with a large effect size), which means that we found a strong indicator that the chosen approach is truly able to help developers.
Label Free Biosensor Methods in Detection of Food Pathogens and Listeria monocytogenes

Food pathogens contaminate food products that allow their growth on the shelf and also 8 under refrigerated conditions. Therefore, it is of utmost importance to lower the limit of detection 9 (LOD) of the method used and to obtain the results within hours to few days. Biosensor methods 10 exploit the available technologies to individuate and provide an approximate quantification of the 11 bacteria present in a sample. The main bottleneck of these methods depend on the aspecific 12 binding to the surfaces and on a change in sensitivity when bacteria are in a complex food matrix 13 in respect to bacteria in a liquid food sample. In this review we introduce Surface Plasmon 14 Resonance (SPR), new advancements in SPR techniques, and Electrochemical Impedance 15 Spectroscopy (EIS), as label-free biosensing technologies for the detection of L. monocytogenes in 16 foods. The application of the two methods has made possible the detection of L. monocytogenes 17 with LOD of 1 log CFU/mL. Further advancement are envisaged through the combination of 18 biosensor methods with immunoseparation of bacteria from larger volumes. 19
Associations among halotolerance, osmotolerance and exopolysaccharide production of Aureobasidium melanogenum strains from habitats under salt stress

Associations among halotolerance, osmotolerance and exopolysaccharide (EPS) production of 50 Aureobasidium melanogenum strains isolated from various habitats along the coasts of Thailand were compared. Using Fisher’s Exact Test, significant associations were found between halotolerance vs osmotolerance (P = 0.004), halotolerance vs EPS production (P = 0.049) and osmotolerance vs EPS production (p0.001). Highly to moderately halotolerant strains were found to be moderately osmotolerant, but not vice versa. Tolerant strains against either salt or sugar produced moderate to low EPS yield. Strains intolerant to salt and/or sugar varied widely in EPS production. The effect of osmotic stress on the growth and EPS yield were investigated with three strains different in halotolerance, osmotolerance and EPS production by comparing their cultures in media with increasing sucrose concentrations. As sucrose concentration increased, a significant reduction in conversion efficiency was observed. Both moderately halotolerant (PBUAP13) and osmotolerant (PBUAP50) strains with moderate EPS production lost their conversion efficiency more drastically than the relatively stress intolerant, high EPS producing strain (PBUAP34). The reduction in EPS production at high osmotic stress was apparently not the result of growth inhibition for both moderately tolerant strains. Cellular accumulation of mannitol was detected in all strains tested.
Operating Systems Challenges for GPU Resource Management

The graphics processing unit (GPU) is becoming a very powerful platform to accelerate graphics and data-paralle l compute-intensive applications. It significantly outperforms traditional multi-core processors in performance and ener gy effi ciency. Its application domains also range widely from embedded systems to high-performance computing systems. However, operating systems support is not adequate, lackin g models, designs, and implementation efforts of GPU resource management for multi-tasking environments. This paper identifies a GPU resource management model to provide a basis for operating systems research using GPU technology. In particular, we present design concepts for G PU resource management. A list of operating systems challenge s is also provided to highlight future directions of this rese arch domain, including specific ideas of GPU scheduling for realtime systems. Our preliminary evaluation demonstrates tha t the performance of open-source software is competitive wit h that of proprietary software, and hence operating systems r esearch can start investigating GPU resource management.
The HCN Gene Family: Molecular Basis of the Hyperpolarization‐Activated Pacemaker Channels

ABSTRACT: The molecular basis of the hyperpolarization‐activated cation channels that underlie the anomalous rectifying current variously termed Ih, Iq, or If is discussed. On the basis of the expression patterns and biophysical properties of the newly cloned HCN ion channels, an initial attempt at defining the identity and subunit composition of channels underlying native Ih is undertaken. By comparing the sequences of HCN channels to other members of the K channel superfamily, we discuss how channel opening may be coupled to membrane hyperpolarization and to direct binding of cyclic nucleotide. Finally, we consider some of the questions in cardiovascular physiology and neurobiology that can be addressed as a result of the demonstration that Ih is encoded by the HCN gene family.