Miracle-dz/UniFAR-FTUs huggingface dataset:
Recurrent ischemic stroke is predicted by intracranial large artery stenosis identified by brain MRA: an observational study of 693 patients from Kaohsiung, Taiwan.

PURPOSE This study aimed to explore the incidence, severity and risk factors of recurrent stroke after stroke stratified by intracranial large artery stenosis (ILAS). METHODS This was an observational study of 693 ischemic stroke patients recruited in a medical center in southern Taiwan. ILAS was identified by MRA. Vascular risk factors, therapeutic conditions and stroke severity were evaluated prospectively. Risk of events was estimated by Kaplan-Meier survival analysis and adjusted for sex, age along with all the variables of interest by Cox proportional hazard models. RESULTS The mean observation period was 1.1 year with no lost to follow up. There were 57 (8.2%) patients suffered from recurrent ischemic stroke with 6 (10.5%) dead. Recurrent stroke rate was 2.3% within first month after stroke, 1.5% 31-90 days, 3% 91-365 days, and 1.2% within 365-730 days. Annual stroke recurrence was 8.6% (95%CI, 7.7-9.5). History of ischemic stroke (HR 2.793, 1.550-5.043) and ILAS (HR 2.193, 1.197-4.018) were associated with increased risk of recurrence. CONCLUSION History of ischemic stroke along with ILAS related to the recurrence. Most of the recurrent stroke was mild in severity. Possibly due to the short interval of observation, recurrent stroke was not related to increased mortality.
Description of OPRA: A Danish database designed for the analyses of risk factors associated with 30-day hospital readmission of people aged 65+ years

Aims: To describe the construction of the Older Person at Risk Assessment (OPRA) database, the ability to link this database with existing data sources obtained from Danish nationwide population-based registries and to discuss its research potential for the analyses of risk factors associated with 30-day hospital readmission. Methods: We reviewed Danish nationwide registries to obtain information on demographic and social determinants as well as information on health and health care use in a population of hospitalised older people. The sample included all people aged 65+ years discharged from Danish public hospitals in the period from 1 January 2007 to 30 September 2010. We used personal identifiers to link and integrate the data from all events of interest with the outcome measures in the OPRA database. The database contained records of the patients, admissions and variables of interest. Results: The cohort included 1,267,752 admissions for 479,854 unique people. The rate of 30-day all-cause acute readmission was 18.9% (n=239,077) and the overall 30-day mortality was 5.0% (n=63,116). Conclusions: The OPRA database provides the possibility of linking data on health and life events in a population of people moving into retirement and ageing. Construction of the database makes it possible to outline individual life and health trajectories over time, transcending organisational boundaries within health care systems. The OPRA database is multi-component and multi-disciplinary in orientation and has been prepared to be used in a wide range of subgroup analyses, including different outcome measures and statistical methods.
Prediction models in obstetrics: understanding the treatment paradox and potential solutions to the threat it poses

the treatment paradox and potential solutions to the threat it poses F Cheong-See, J Allotey, N Marlin, BW Mol, E Schuit, G ter Riet, RD Riley, KGM Moons, KS Khan, S Thangaratinam a Women’s Health Research Unit, Barts and the London School of Medicine and Dentistry, Blizard Institute, Queen Mary University London, London, UK b Multidisciplinary Evidence Synthesis Hub (MESH), Queen Mary University of London, UK c Pragmatic Clinical Trials Unit, Barts and the London School of Medicine and Dentistry, Blizard Institute, Queen Mary University London, London, UK d Australian Research Centre for Health of Women and Babies, Robinson Institute, The University of Adelaide, Adelaide, SA, Australia e Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, the Netherlands f Stanford Prevention Research Center, Stanford University, Stanford, CA, USA g Department of General Practice, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands h Research Institute for Primary Care and Health Sciences, Keele University, Staffordshire, UK Correspondence: Prof S Thangaratinam, Women’s Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University London, Yvonne Carter Building, 58 Turner Street, London E1 2AB, UK. Email s.thangaratinam@qmul.ac. uk
Investigation of Hot Carrier Degradation Modes in LDMOS by using a Novel Three-Region Charge Pumping Technique

Hot carrier stress induced oxide degradation in n-LDMOS is investigated by using a novel three-region charge pumping technique. This technique allows us to locate oxide damage area in various stress modes and gain insight into trap creation properties. Our characterization shows that a max. Ig stress causes a largest drain current and subthreshold slope degradation because of both interface trap (Nit) generation in the channel region and negative bulk oxide charge (Qox) creation in the bird's beak region. The density of Nit and Qox can be separately extracted from the proposed charge pumping method. A numerical device simulation is performed to confirm our result
Teaching Old Dogs New Tricks: RN "Returnship" Program

RN shortages, lack of experienced RNs, technological advances, closed doors to RNs without recent acute care experience-these are the common problems making it difficult for experienced RNs to return to the hospital setting after an extended absence. Solution? A specialized orientation-the "RN Returnship Program. " This creative and adaptable medical-surgical nursing program met these unique needs. The Returnship Program was designed to support "old dog" RNs and teach them the "new tricks" of acute care nursing.
Rooibos (Aspalathus linearis) and its Major Flavonoids — Potential Against Oxidative Stress-Induced Conditions

Reactive species are products of normal cellular metabolism and may be deleterious or beneficial. At low/moderate concentrations, reactive species are involved in physiological roles including cell signalling, defense against infectious agents and mitogenic responses. However, unbalanced defense mechanism of antioxidants, overproduction of reactive species or incorporation of free radicals into the living system from the environment may result in oxidative stress, a deleterious process that can lead to damage of important cell structures, including lipids and membranes, proteins and nucleic acids. The role of oxida‐ tive stress as a contributing factor in the pathophysiology of various diseases is increas‐ ingly being recognized, and augmenting the oxidative defense capacity of the cell through the intake of antioxidants as a way of preventing free radical-mediated cellular injuries is becoming a popular strategy. Much attention is being focused on the health beneficial role of phenolic phytochemicals derived from plants. They are considered to play an important role as physiologically functional foods and for the prevention of clini‐ cal conditions related to oxidative stress, even though their modes of action may still not be fully understood. Rooibos (Aspalathus linearis) is a popular South African tisane en‐ joyed for its taste and aroma. Rooibos has been made in the Cederberg mountain region of South Africa for generations and has been used medicinally for alleviation of allergies, asthma, infantile colic and skin problems. The potential antioxidative, immune-modulat‐ ing, chemopreventive and chemotherapeutic actions of rooibos have been reported in several studies. This review provides a comprehensive data on the current knowledge of the biological and chemotherapeutic activity of rooibos and its major flavonoids. Most re‐ cent in vitro and in vivo (animal and human) studies were conducted with special atten‐ tion paid to clinical conditions in which oxidative stress has been implicated. The conclusion described directions for future rooibos research to establish its activity and utility as a human chemopreventive and therapeutic agent.