Miracle-dz/UniFAR-FTUs huggingface dataset:
Survey of Sarcocystis Species Infection in Slaughtered Goats in Makurdi Metropolis

The emerging zoonotic infection caused by Sarcocystis species is becoming a serious public health problem for animal rearers . This study was conducted to determine the prevalence of Sarcocystis species infection in slaughtered goats at some selected abattoirs in Makurdi metropolis. Histological investigation was carried out using Haematoxylin and Eosin (H and E) as the staining agent on the tissue samples of heart (21), oesophagus (191) and tongue (183) from 224 goats. The results showed that, out of the 224 goats examined, 84(37.50%) were observed to be infected with Sarcocystis species. Morphologically some appeared round, ovoid or globular while others were elongated, spindle-shaped that tapered at one end. Infection related to sex showed that females had higher (83.33%) rate than males (16.67%). With respect to infection due to age, 9.52, 28.57 and 61.91% for ages 1-2 years, 2-3 years and above 3 years respectively were noted. Sex and age of the animals were not determining factors of the infection (P>0.05). There was significant difference in prevalence of infection in the three muscular tissues examined, with oesophagus having the highest (63.10 %) followed by the tongue (34.52%) and heart being the least (2.38%) (P< 0.05). The presence of two distinct microscopic cyst shapes (elongated, spindle-shaped that taper at one end and the round, oval or globular form) prompts the need for further research to ascertain species-specific associated with this parasite in goats and other animals in Nigeria.
Frequency of 1,25-dihydroxyvitamin D3 receptor in human breast cancer.

Receptors for 1,25-dihydroxyvitamin D3 have been shown to exist in cultured breast cancer cells and in primary breast cancers. It is reported here that 1,25-dihydroxyvitamin D3 receptor (1,25-DR) was present in 80% of 54 unselected breast cancers. The concentration of 1,25-DR in the 43 receptor-positive tumors was 1.9 +/- 0.4 fmol/mg protein (S.E.). There was no correlation between 1,25-DR presence or concentration and the age of the patient or the concentration of estrogen, progesterone, androgen, or glucocorticoid receptors. 1,25-DR was also found in two of three renal cortical carcinomas but only in three of 14 gastrointestinal tract carcinomas. The relatively low concentration of 1,25-DR in these breast cancers, compared with that found in cultured breast cancer cells, is partially explained by incomplete "exchange" with occupied receptors. Since the serum vitamin D-binding protein is not precipitated from serum itself or from tissue homogenates using the polyethylene glycol method, artifactual 1,25-DR levels due to the inevitable contamination of tissue specimens with this protein can be excluded. These findings indicate that 1,25-DR is not a nonspecific marker of cancer. The high frequency of 1,25-DR in the breast cancers may be related to the calcium-transporting ability of breast cancer cells which allows them to grow as osteolytic metastases.
Influences of Patellofemoral Pain and Fatigue in Female Dancers during Ballet Jump-Landing

Abstract This study investigated the influence of patellofemoral pain (PFP) and fatigue on lower-extremity joint biomechanics in female dancers during consecutive simple ground échappé. 3-dimensional joint mechanics were analyzed from the no-fatigue to fatigue conditions. 2-way mixed ANOVAs were used to compare the differences of the kinematic and kinetic variables between groups and conditions. Group main effects were seen in increased jump height (p=0.03), peak vertical ground reaction force (p=0.01), knee joint power absorption (p=0.04), and patellofemoral joint stress (PFJS, p=0.04) for PFP group. Fatigue main effects were found for decreased jump height (p<0.01), decreased ankle plantarflexion at initial foot-ground contact (p=0.01), and decreased ankle displacement (p<0.01). Hip external rotation impulse and hip joint stiffness increased (both p<0.01) while knee extension and external rotation moment, and ankle joint power absorption decreased (p<0.01, p=0.02, p<0.01, respectively) after fatigue. The peak PFJS also decreased after fatigue (p<0.01). Female ballet dancers with PFP sustained great ground impact and loads on the knee probably due to higher jump height compared to the controls. All dancers presented diminished knee joint loading for the protective mechanism and endurance of ankle joint musculature required for the dissipation of loads and displayed a distal-to-proximal dissipation strategy after fatigue.
Prediction of response within the first 3 days to treatment with paroxetine for depression.

OBJECTIVE In the treatment of depression, clinical and psychopharmacologic aspects have been investigated to predict the response to anti-depressants. Some trials have reported clinical improvement as early as the first week; however, few have investigated the early effects of selective serotonin reuptake inhibitors. The aim of this study was to investigate therapeutic efficacy of paroxetine within the first 3 days of therapy onset. METHOD Subjects included 29 outpatients diagnosed at first interview with major depressive disorder according to DSM-IV criteria (June 2003 to January 2007). Paroxetine 5-20 mg/day was administered for at least 2 weeks. Treatment efficacy was defined as a > 50% decrease in Hamilton Rating Scale for Depression (HAM-D) total scores from baseline to the end of the second week. To determine efficacy within the first 3 days, patients completed the HAM-D as a self-rated questionnaire on the first and third days and at the end of the first, second, and fourth weeks. RESULT Subjects were divided into 2 groups: successful (17 responders) and failed (12 non-responders). There was a significant difference between the reduction rates of self-rated HAM-D total scores on the third day (p < .01). CONCLUSION In patients responding to paroxetine in the early stages of treatment, the prediction of response within the first 3 days using the self-rated HAM-D is suggested.
Striding Toward Social Justice: The Ecologic Milieuof Physical Activity

Disparities in physical activity should be investigated in light of social justice principles. This article critically evaluates evidence and trends in disparities research within an ecologic framework, focusing on multilevel factors such as neighborhood and racial discrimination that influence physical activity. Discussion focuses on strategies for integrating social justice into physical activity promotion and intervention programming within an ecologic framework.
Effective metacomputing using LSF Multicluster

LSF (Load Sharing Facility) MultiCluster is the enabling software which allows load sharing among disparate LSF clusters. It supports transparent access to remote cluster configuration and load information, distribution of jobs among clusters, importing and exporting of batch queues between clusters, configurable user account mapping at the individual user level and automatic file transfer. The paper describes certain in-depth technical details of the internal workings of LSF MultiCluster.
THE SPITZER SURVEY OF INTERSTELLAR CLOUDS IN THE GOULD BELT. V. OPHIUCHUS NORTH OBSERVED WITH IRAC AND MIPS

We present Spitzer IRAC (2.1 deg2) and MIPS (6.5 deg2) observations of star formation in the Ophiuchus North (Oph N) molecular clouds. This fragmentary cloud complex lies on the edge of the Sco–Cen OB association, several degrees to the north of the well-known ρ Oph star-forming region, at an approximate distance of 130 pc. The Oph N clouds were mapped as part of the Spitzer Gould Belt project under the working name “Scorpius. ” In the regions mapped, selected to encompass all the cloud with visual extinction AV > 3, 11 young stellar object (YSO) candidates are identified, 8 from IRAC/MIPS color-based selection and 3 from Two Micron All Sky Survey (2MASS) KS/MIPS colors. Adding to one source previously identified in L43, this increases the number of YSOcs identified in Oph N to 12. During the selection process, four color-based YSOcs were rejected as probable asymptotic giant branch stars and one as a known galaxy. The sources span the full range of YSOc classifications from Class 0/1 to Class III, and starless cores are also present. Twelve high extinction (AV > 10) cores are identified with a total mass of ∼100 M☉. These results confirm that there is little ongoing star formation in this region (instantaneous star formation efficiency <0.34%) and that the bottleneck lies in the formation of dense cores. The influence of the nearby Upper Sco OB association, including the 09V star ζ Oph, is seen in dynamical interactions and raised dust temperatures but has not enhanced levels of star formation in Oph N.
Less adrenergic activation during cataract surgery with total intravenous than with local anesthesia

Background: Previous studies reported that, contrary to local anesthesia, cataract surgery under inhalational anesthesia is associated with substantial adrenergic activation. We tested the hypothesis that total intravenous anesthesia (TIVA) with propofol and alfentanil produces less or comparable adrenergic activation during cataract surgery than local anesthesia.
A case series of cefixime induced Steven’s Johnson Syndrome

Drug induced adverse reactions are a major health problem. Drug hyper sensitivity reactions manifest themselves in many diseases, of which some are very severe. The most common allergic reactions occur in the skin. Stevens-Johnson syndrome is mainly caused by drugs (antimicrobials e.g.: penicillin’s, sulphonamides and cephalosporin’s e.g.: cefixime, antiepileptic’s, NSAIDS), infections and also by other risk factors not yet identified. The most common allergic reactions occur in the skin. These reactions ranging from simple pruritic eruptions to potentially life threatening events are a significant cause of iatrogenic morbidity and mortality. Identification of the cause, withdrawal of the trigger and supportive management is crucial to improve the patient state. Despite of all therapeutic efforts, mortality is high and increases with disease severity, patient’s age and underlying medical conditions. Survivors may suffer from long-term squeal such as strictures of mucous membranes including severe eye problems.
A Software Architecture for Knowledge Discovery in Database

Currently, most of the companies have computational systems to provide support to the operational routines. Technologies of data warehousing and data mining have appeared to solve the problem of search for necessary and trustworthy information for decision-making. However, the existing solutions do not enclose those two technologies; some of them are directed to the construction of a data warehouse and others to the application of data mining techniques. This paper presents a software architecture that defines the components necessary for implementation of knowledge discovery systems in database. Some standards of best practices in projects and in development were used since the definition until the implementation.
TGF‐β induces the expression of the FLICE‐inhibitory protein and inhibits Fas‐mediated apoptosis of microglia

During inflammatory reactions in the central nervous system (CNS), resident macrophages, the microglia, are exposed to Th1 cell‐derived cytokines and pro‐apoptotic Fas ligand (FasL). Despite the presence of TNF‐α and IFN‐γ, both being capable of sensitzing microglia to FasL, apoptosis of microglia is not a hallmark of inflammatory diseases of the CNS. In the present study, TGF‐β is found to counteract the effect of TNF‐α and IFN‐γ to sensitize microglia to FasL‐mediated apoptosis. Resistance to Fas‐mediated apoptosis by TGF‐β does not correlate with a down‐regulation of Fas expression. As a key inhibitor of Fas‐mediated apoptosis, we found expression of the cellular FLICE‐inhibitory protein (c‐FLIP) to be induced by TGF‐β in resting as well as in activated microglia. Induction of FLIP was found to depend on a mitogen‐activated protein kinase kinase (MKK)‐dependent pathway as shown by the use of the specific MKK‐inhibitor PD98059. The presence of FLIP strongly interfered with FasL‐induced activation of caspase‐8 and caspase‐3 preventing subsequent cell death. The presented data provide the first evidence for a TGF‐β‐mediated FLIP in macrophage‐like cells and suggest a mode of action for the anti‐apoptotic role of TGF‐β in the CNS.
Incremental Validity of Test Session and Classroom Observations in a Multimethod Assessment of Attention Deficit/Hyperactivity Disorder

This study tested the incremental validity of behavioral observations, over and above parent and teacher reports, for assessing symptoms of Attention Deficit/Hyperactivity Disorder (ADHD) in children ages 6 to 12, using the Test Observation Form (TOF) and Direct Observation Form (DOF) from the Achenbach System of Empirically Based Assessment. The TOF Attention Problems and DOF Intrusive scales contributed significant unique variance, over and above parent and teacher ratings, to predicting parent and teacher ratings of hyperactivity and impulsivity and predicting categorical diagnoses of ADHD-Combined type versus Non-ADHD and ADHD-Combined type versus ADHD-Predominantly Inattentive type. The TOF Oppositional and Attention Deficit/Hyperactivity Problems scales contributed unique variance to predicting parent ratings of hyperactivity and impulsivity and the DOF Oppositional and Attention Deficit/Hyperactivity Problems scales contributed unique variance to predicting teacher ratings of hyperactivity and impulsivity.
Quantification of Glucosylceramides in Wheat Extracts Using High-Performance Liquid Chromatography with Evaporative Light-Scattering Detection

In this report, we describe a simple and rapid HPLC method to analyze glucosylceramide content in wheat extracts and product formulations containing wheat extracts. The HPLC separation of glucosylceramides from other glycolipids was performed on a normal-phase (diol) column followed by evaporative light scattering detection to quantify the glucosylceramide content. The method was validated for selectivity, precision, and accuracy. The recovery of glucosylceramides from spiked matrix samples was approximately 100%, and the limits of detection and quantification were 0.03 mg/mL and 0.1 mg/mL, respectively. The electron light scattering detector response fits well into a power equation for calibration. The assay precision (relative standard deviation values) was less than 3% for repeatability and less than 4% for reproducibility.
FIRST REPORT OF INTRAMOLLUSCAN STAGES OF A GORGODERID DIGENEAN FROM A MARINE BIVALVE

A survey of bivalves from Heron Island on the Great Barrier Reef, Australia, revealed a novel digenean infection in Lioconcha castrensis (Bivalvia: Veneridae). The cercaria has oral and ventral suckers, a dorsoventrally orientated stylet embedded in the oral sucker, penetration glands, and a large tail that is inflated at its base. This morphology is broadly consistent with that of previously described gorgoderid cercariae. Partial large subunit ribosomal RNA gene (D1–D3 domains) was sequenced and aligned with sequences from other gorgoderids and related families. Phylogenetic analysis also suggests that the species belongs to the Gorgoderinae. To our knowledge, this is the first report of a gorgoderid from a marine bivalve.
Supplementary Material for “ Learning the Network Structure of Heterogeneous Data via Pairwise Exponential Markov Random Fields ”

where (b) holds by applying chain rule successively, and (c) holds because conditioning reduces entropy. Note that, for a known exponential family distribution, H(Xr | Br(X)) is constant. For examples in a Gaussian, Dirichlet, Gamma, Wishart, Xr is also a function of Br(Xr), meaning H(Xr | Br(X)) = 0. For a Laplacian distribution, H(Xr | Br(X)) = H(Sign(Xr)) = 1. Therefore, we can conclude that H(X) = H(bnode(X)) + C0 where C0 = ∑p r=1 H(Xr | Br(X)) is the constant determined by the types of nodes.
Collective Personalized Change Classification With Multiobjective Search

Many change classification techniques have been proposed to identify defect-prone changes. These techniques consider all developers' historical change data to build a global prediction model. In practice, since developers have their own coding preferences and behavioral patterns, which causes different defect patterns, a separate change classification model for each developer can help to improve performance. Jiang, Tan, and Kim refer to this problem as personalized change classification, and they propose PCC+ to solve this problem. A software project has a number of developers; for a developer, building a prediction model not only based on his/her change data, but also on other relevant developers' change data can further improve the performance of change classification. In this paper, we propose a more accurate technique named collective personalized change classification (CPCC), which leverages a multiobjective genetic algorithm. For a project, CPCC first builds a personalized prediction model for each developer based on his/her historical data. Next, for each developer, CPCC combines these models by assigning different weights to these models with the purpose of maximizing two objective functions (i.e., F1-scores and cost effectiveness). To further improve the prediction accuracy, we propose CPCC+ by combining CPCC with PCC proposed by Jiang, Tan, and Kim To evaluate the benefits of CPCC+ and CPCC, we perform experiments on six large software projects from different communities: Eclipse JDT, Jackrabbit, Linux kernel, Lucene, PostgreSQL, and Xorg. The experiment results show that CPCC+ can discover up to 245 more bugs than PCC+ (468 versus 223 for PostgreSQL) if developers inspect the top 20% lines of code that are predicted buggy. In addition, CPCC+ can achieve F1-scores of 0.60-0.75, which are statistically significantly higher than those of PCC+ on all of the six projects.
Improve load balancing and coding efficiency of tiles in high efficiency video coding by adaptive tile boundary

High efficiency video coding (HEVC) not only improves the coding efficiency drastically compared to the well-known H.264/AVC but also introduces coding tools for parallel processing, one of which is tiles. Tile partitioning is allowed to be arbitrary in HEVC, but how to decide tile boundaries remains an open issue. An adaptive tile boundary (ATB) method is proposed to select a better tile partitioning to improve load balancing (ATB-LoadB) and coding efficiency (ATB-Gain) with a unified scheme. Experimental results show that, compared to ordinary uniform-space partitioning, the proposed ATB can save up to 17.65% of encoding times in parallel encoding scenarios and can reduce up to 0.8% of total bit rates for coding efficiency.
A privilege escalation vulnerability checking system for android applications

Android is a free, open source mobile platform based on the Linux kernel. The openness of the application platform attracts developers, both benign and malicious. Android depends on privilege separation to isolate applications from each other and from the system. However, a recent research reported that a genuine application exploited at runtime or a malicious application can escalate granted permissions. The attack depends on a carelessly designed application which fails to protect the permissions granted to it. In this research, we propose a vulnerability checking system to check if an application can be potentially leveraged by an attacker to launch such privilege escalation attack. We downloaded 1038 applications from the wild and found 217 potentially vulnerable applications that need further inspection.
Juvenile Myelomonocytic Leukemia (JMML) Cells Spontaneously Differentiate into Dendritic-cell Like Populations in vitro

Objective: Juvenile myelomonocytic leukemia (JMML) is a rare myelodysplastic/ myeloproliferative malignancy of early childhood, characterized by monocytosis, hepatos­plenomegaly and an aggressive clinical course. Methods: In semi-solid culture JMML progenitor cells proliferate spontaneously into colony forming units. In order to study the mechanisms of proliferation and differentiation of JMML cells we developed a suspension culture system without additional exogenous growth factor supplement. Mononuclear cells (MNC) from peripheral blood, bone marrow or spleen of 14 patients with JMML and 24 controls were studied. Findings: JMML cells expressed higher levels of the proliferation marker Ki67 (median 24% [7-39%] vs a median of 3.5% in controls). 90% of JMML cells were CD68-positive (vs 35% in controls) and by day 7 all JMML samples contained CD1a- positive cells. Electron microscopy demonstrated cytoplasmic vesicular structures resembling multilamellar MHC II compare­timents, which together with the expression of CD1a - support a dendritic cell (DC)-phenotype. Conclusion: Differentiation into CD1a-positive DC seems to be a frequent phenomenon in cultured JMML MNC, which in vivo may contribute to clinical characteristics such as skin and organ infiltration.
Genome Sequence for Shiga Toxin-Producing Escherichia coli O26:H11, Associated with a Cluster of Hemolytic-Uremic Syndrome Cases in South Africa, 2017

ABSTRACT Shiga toxin-producing Escherichia coli (STEC) strains are primarily foodborne pathogens that may cause diarrheal outbreaks and are associated with severe complications, specifically hemolytic-uremic syndrome (HUS). We report here genome sequence data for STEC O26:H11, which is associated with a cluster of cases of HUS, a rarely described syndrome in South Africa.
Fundamental design problems of distributed systems for the hard-real-time environment

Software designed to function in a hard-real-time environment where strict timing constraints must be met often entails implicit assumptions about a programming language and the underlying system which supports it. Programs which are logically correct, i.e., they implement the intended algorithms, may not function correctly if their assumed timing characteristics of the software or if the expressible timing characteristics cannot be verified before run time. For distributed systems in particular, the software must be tailored to a myriad of implementation parameters, e.g., communication bandwidth, thus rendering subsequent modifications hazardous. Our research investigates the basic problems in automating the design and maintenance of hard real-time software. After examining the limitations of the traditional approach to real-time software design via process-based models, we shall provide a graph-based computation model which is more suitable for expressing the computation requirements of the real-time environment. This model is an extension of CONSORT (Control Structure Optimized for Real-Time), an experimental software design system which has been implemented to generate process control application programs from block diagram schemata. While our graph-based model is abstract, it can serve as a useful intermediate representation between textual requirements specifications and target application programs. Using the graph-based model, the complexity of the relevant resource allocation problems for meeting stringent timing constraints is investigated.