Miracle-dz/UniFAR-FTUs huggingface dataset:
Semi-additive Cu-polymer RDL process for interposers applications

This paper explores the possibility to use insulating spin-on dielectric materials for 2.5D interposers. Up to 7 photosensitive materials have been investigated in terms of minimum line/space and via resolution to determine the maximum wiring density. In addition the electrical performances of the best materials were assessed in DC and RF to extract the dielectric constant and loss tangent. Finally the polymer semi-additive process was compared to a Damascene technology using the Wide I/O 2 as case study. The overall performances of each technology are assessed in terms of electrical performances, cost of ownership and wafer bowing. It was shown that the semiadditive process can compete with a conventional Damascene process. The best performing material is a phenol-based polymer, positive tone, aqueous developable, low temperature cure and with a high resolution (up to AR of 1:3).
Adaptation contextuelle de l'information de conscience de groupe dans les SIW collaboratifs

RESUME . L’utilisation des nouvelles technologies mobiles impose aux Systemes d’Informations sur le Web (SIW) collaboratifs d’adapter leur contenu aux contraintes d’une utilisation nomade. Nous proposons ici un processus de filtrage guide par le contexte dont l’objectif est d’adapter l’information de conscience de groupe delivree aux utilisateurs de ces systemes dans ce type d’utilisation. L’information de conscience de groupe est une information caracteristique des SIW collaboratifs qui doit permettre a un utilisateur de mieux coordonner ses propres activites vis-a-vis de celles du groupe. Le processus de filtrage repose d’une part sur un modele du contexte d’utilisation qui integre aussi bien les aspects physiques de l’utilisation du systeme que les aspects lies a la collaboration, et, d’autre part, sur la notion de profils. Les profils associent des regles de filtrage a un ensemble de contextes potentiels d’utilisation stockes par le SIW collaboratif. Le processus de filtrage agit en deux etapes. La premiere selectionne les profils dont un contexte potentiel correspond au contexte courant de l’utilisateur. La seconde filtre l’information de conscience de groupe associees a ces profils selon les regles exprimees.
Design of Chipless RFID Tags Printed on Paper by Flexography

In this paper, we demonstrate for the first time that a 19-bit chipless tag based on a paper substrate can be realized using the flexography technique, which is an industrial high-speed printing process. The chipless tag is able to operate within the ultra-wide band (UWB) and has a reasonable size ( 7×3 cm 2) compared to state-of-the-art versions. Thus, it is possible to use this design for various identification applications that require a low unit cost of tags. Both the simulation and measurement results are shown, and performance comparisons are provided between several realization processes, such as classical chemical etching, flexography printing, and catalyst inkjet printing.
Psychometric comparison of standard and computerized administration of the Alzheimer’s Disease Assessment Scale: Cognitive Subscale (ADASCog).

BACKGROUND The Alzheimer’s Disease Assessment Scale – Cognitive Subscale (ADAS-Cog) has become the de facto gold standard for assessing the efficacy of anti-dementia treatments. However, manual administration of the ADAS-Cog is subject to procedural inconsistencies, including scoring and transcription errors, which can introduce unwanted variance and compromise data quality within and across sites and trials. To address such concerns, a computerized version was developed that integrates, rather than replaces, the examiner, standardizes administration, and uses electronic data capture at the point of patient contact. The examiner can control administration and pacing, pause or repeat digitized instructions, score verbal report and overt behavioral performance, and freely interact with the subject. PURPOSE To conduct psychometric comparisons of traditional, paper-based administration of the standard ADAS-Cog (sADAS) with examiner- assisted administration of the computerized ADAS-Cog (cADAS). METHODS Eighty-eight patients (39M; 49F) with mild to moderate Alzheimer’s disease were tested on three occasions with each version over a period of one year with one month between paired visits. RESULTS Intraclass Correlation Coefficients (ICC) comparisons between sADAS and cADAS were significant for total score (ICC=0.96) and all subscores (ICCs ranged 0.78-0.93), with no significant differences on paired t-tests. The mean ICCs across cADAS scores for test-retest reliability for short-term (mean ICC=0.96) and long-term (mean ICC=0.91) comparisons were significantly higher than across sADAS scores (mean ICCs were 0.87 and 0.84, respectively). CONCLUSIONS These results indicate that examiner-assisted, computerized administration is equivalent to traditional, paper-based administration, and shows significantly greater test-retest reliability.
GATA‐4 is required for sex steroidogenic cell development in the fetal mouse

The transcription factor GATA‐4 is expressed in Sertoli cells, steroidogenic Leydig cells, and other testicular somatic cells. Previous studies have established that interaction between GATA‐4 and its cofactor FOG‐2 is necessary for proper Sry expression and all subsequent steps in testicular organogenesis, including testis cord formation and differentiation of both Sertoli and fetal Leydig cells. Since fetal Leydig cell differentiation depends on Sertoli cell–derived factors, it has remained unclear whether GATA‐4 has a cell autonomous role in Leydig cell development. We used two experimental systems to explore the role of GATA‐4 in the ontogeny of testicular steroidogenic cells. First, chimeric mice were generated by injection of Gata4−/− ES cells into Rosa26 blastocysts. Analysis of the resultant chimeras showed that in developing testis Gata4−/− cells can contribute to fetal germ cells and interstitial fibroblasts but not fetal Leydig cells. Second, wild‐type or Gata4−/− ES cells were injected into the flanks of intact or gonadectomized nude mice and the resultant teratomas examined for expression of steroidogenic markers. Wild‐type but not Gata4−/− ES cells were capable of differentiating into gonadal‐type steroidogenic lineages in teratomas grown in gonadectomized mice. In chimeric teratomas derived from mixtures of GFP‐tagged Gata4+/+ ES cells and unlabeled Gata4−/− ES cells, sex steroidogenic cell differentiation was restricted to GFP‐expressing cells. Collectively these data suggest that GATA‐4 plays an integral role in the development of testicular steroidogenic cells. Developmental Dynamics 236:203–213, 2007. © 2006 Wiley‐Liss, Inc.
An Index Scheme for XML Documents Based on Relationship Joins

XML is rapidly emerging as a standard for information storage, representation and exchange on the Web. How to rapidly search and query XML documents efficiently has received many attentions in resent research. However, current querying schemes of XML documents typically involve in both node content and tree structural information, which may limit efficiency when facing the application that the tree structural information is more complicated than the tree node itself. In this paper, we propose the node relationships joins algorithms that utilize available indexes mainly on tree structural information. The relationships join algorithms work perfectly especially for searching paths that are very long or whose lengths are unknown. Experimental results from our prototype system implementation highlight the correctness and efficiency of our solution
The mental health of adolescents with and without mild/moderate intellectual disabilities in England: Secondary analysis of a longitudinal cohort study

BACKGROUND Children with mild/moderate intellectual disabilities are at greater risk for mental health problems, with socio-economic factors and adversity partly accounting for this. Fewer data are available for adolescents. METHODS Secondary analysis was undertaken of the Next Steps annual panel study following a cohort through adolescence into adulthood containing self-report mental health data up to age 16/17. Participants with mild/moderate intellectual disabilities were identified through data linkage with educational records. RESULTS Adolescents with mild/moderate intellectual disabilities were more likely than non-disabled peers to experience socio-economic disadvantage and bullying. Incidence rates of mental health problems were generally not significantly different between adolescents with and without intellectual disabilities. CONCLUSIONS These findings are consistent with higher rates of persistent mental health problems beginning earlier among children with intellectual disabilities. Greater attention needs to be paid to the timecourse of mental health problems, and the impact of socio-economic factors, family and peers on mental health.
Theoretical Model of Ungrounded Inductance Realized With Two Gyrators

The traditional approach to simulate ungrounded inductors in active gyrator filters uses two gyrators with all equal transconductances. However, this paper shows that the differences between gyrator transconductances can be employed to obtain certain advantages. The filter can be designed with extra gain and with different terminating resistors, but without need of any additional buffer amplifiers. These advantages are achieved by using an appropriate theoretical model of the gyrator simulated floating inductance in the filter design process. The model separates the simulated inductance from the amplification, thus suggesting more flexible filter design. Further the model is extended to reflect also some OTA imperfections-their input and output impedances and their noise generation. In addition, the discussed model gives a unified approach for theoretical analysis of gyrator LC filters with floating inductors.
Work Informatics - Mon Amour

This article displays the professional career of the author. It is started with a chronological narrative of his academic work highlighting some crucial events in it. The main contribution of his work is a conceptual framework called ‘Work Informatics’ that regards the use of information technology as an inherent part of the work of the actual user. This framework is briefly explained. The final discussion tries to transcend the restrictions created by the unusual subjective character of this paper: what are the lessons learned and how are the two stories connected?
Amiodarone Destabilizes Intracellular Ca2+ Homeostasis and Biosynthesis of Sterols in Leishmania mexicana

ABSTRACT Leishmaniasis represents a serious public health problem worldwide. The first line of treatment is based on glucantime and pentostan, which generate toxic effects in treated patients. We have recently shown that amiodarone, frequently used as an antiarrhythmic, possesses activity against Trypanosoma cruzi through the disruption of mitochondrial Ca2+ homeostasis and the inhibition of parasite ergosterol biosynthesis, specifically at the level of oxidosqualene cyclase activity (G. Benaim, J. Sanders, Y. Garcia-Marchan, C. Colina, R. Lira, A. Caldera, G. Payares, C. Sanoja, J. Burgos, A. Leon-Rossell, J. Concepcion, A. Schijman, M. Levin, E. Oldfield, and J. Urbina, J. Med. Chem. 49:892-899, 2006). Here we show that at therapeutic concentrations, amiodarone has a profound effect on the viability of Leishmania mexicana promastigotes. Additionally, its effect on the viability of the parasite was greater against intracellular amastigotes than against promastigotes, and it did not affect the host cell. Using fluorimetric and confocal microscopy techniques, we also demonstrated that the mechanism of action of amiodarone was related to the disruption of intracellular Ca2+ homeostasis through a direct action not only on the mitochondria but also on the acidocalcisomes. On the other hand, analysis of the free sterols in promastigotes incubated with amiodarone showed that this drug also affected the biosynthesis of 5-dehydroepisterol, which results in squalene accumulation, thus suggesting that amiodarone inhibits the squalene epoxidase activity of the parasite. Taken together, the results obtained in the present work point to a more general effect of amiodarone in trypanosomatids, opening potential therapeutic possibilities for this infectious disease.
Agreement Between Self-Rated and Clinically Assessed Symptoms in Subjects With Psychosis

The aim of this study was to explore the capacity of acutely ill patients with psychosis (N = 40) to self-report their symptoms by comparing self-assessment and objective measures. Positive, negative, and depressive symptoms were rated using the Scale for the Assessment of Positive Symptoms, the Scale for the Assessment of Negative Symptoms, and the Calgary Depression Scale. Insight level was measured using the Scale to Assess Unawareness of Mental Disorder. Patients were asked to self-report positive, negative, and depressive symptoms using the Community Assessment of Psychic Experience. Patients presenting with acute psychotic disorders are able to assess fairly their positive, negative, and depressive symptoms. Significant associations were found between self-reported and objective measures of positive, negative, and depressive symptoms independently of insight level. Individual positive and negative symptoms were correctly self-assessed, except for persecutory delusion and alogia, respectively. These results suggest that self-report questionnaires can be used in educational programs to favor the patient's therapeutic adherence.
Prevention of postoperative nausea and vomiting in patients undergoing laparoscopic bariatric surgery--granisetron alone vs granisetron combined with dexamethasone/droperidol.

BACKGROUND AND OBJECTIVES Laparoscopic bariatric surgeries are associated with an appreciably high rate of postoperative nausea and vomiting. This study was designed to compare the effectiveness of granisetron either alone or in combination with droperidol or dexamethasone, for the prevention of post operative nausea and vomiting (PONV) in patients undergoing laparoscopic bariatric surgeries. METHODS In a randomized, double-blind, placebo-controlled trial, 120 patients received either Granisetron 1 mg, Granisetron 1 mg plus Droperidol 1.25 mg, Granisetron 1 mg plus Dexamethasone 8 mg or Placebo (saline), intravenously immediately before induction of anesthesia. Perioperative anesthetic care was standardized in all patients. Patients were then observed for 24 hours after administration of the study drugs. RESULTS The incidence of PONV was 30% with granisetron alone, 30% with granisetron plus droperidol, 20%, with granisetron plus dexamethanone, and 67% with placebo. (P < 0.05; overall Fisher's exact probability test). The incidence of adverse events was not different among the 4 groups. CONCLUSION Graniserton is effective and safe drug for reducing the incidence of PONV in patients undergoing bariatric surgeries, and becomes highly effective when combined with dexamethasone.
Bureaucratic Corruption, Good Governance and Development: The Challenges and Prospects of Institution Building in Nigeria

The role of the public bureaucracy in achieving good governance cannot be under estimated. This can be gleaned from the central role it playsin the formulation and implementation of policies designed for the development of the society. In Nigerian, the role of the state bureaucracy has come under severe criticisms within the context of that gap that exists between its anticipated role and its actual output in guiding the society along the course leading to the desired goal - development. The failure of the public bureaucracy to deliver the expected output to the society informed the series of reforms that have come to form the policy thrust of successive Nigerian governments since the 1980's. Suffice it to say that the hallmark of such reform has been on the need to have efficient and responsive public sector that has the capacity to meet the challenges posed by the domestic and external environments. The efforts of the Nigerian government have not yielded the much expected results due to the problem of corruption that has eaten deep to the fabric of the Nigerian society - the public bureaucracy not spared. Thus the gains of good governance have been eluding the average Nigerian citizen. This paper argues that good governance encompasses three different but not unrelated dimensions. These are political dimension which centers on the establishment of good objectives and the execise of good leadership. Second, technical dimension which relates to the constraints which are imposed by natural resources, level of education manpower etc and thirdly, institutional dimension which relates to the ability to get things done or precisely efficiency in public management. In view of this, any effort geared toward promoting development in the society must take the three dimensions into consideration. It further posits that thebane of Nigerian public administration is that of corruption which has not allowed the interrelationships that exist among the three variables to provide built - in- mechanism that has the capacity of engendering good governance. It therefore submits that corruption must be positively addressed and reduced in the public bureaucracy for it to be able to meet the challenges of the 21 st century.
Preliminary observations on the microarchitecture of the human abdominal muscles

Precise knowledge of muscle architecture and innervation patterns is essential for the development of accurate clinical and biomechanical models. Although the gross anatomy of the human abdominal muscles has been investigated, the finer details of their microanatomy are not well described. Fascicles were systematically sampled from each of the human abdominal muscles, and small fiber bundles from selected fascicles stained with acetylcholinesterase to determine the location of motor endplate bands, myomyonal junctions, and myotendinous junctions. Statistical analysis was used to ascertain the association between fascicular length and number of endplate bands. The number of endplate bands along a fascicle was variable between different portions of each muscle, but was strongly correlated with fascicular length (r = 0.814). In fascicles less than 50 millimeters (mm) in length, only a single endplate band was generally present, while multiple endplate bands (usually two or three) were found in fascicles longer than 50 mm. The presence of myomyonal junctions throughout the longer (>50 mm) fascicles verified that they were composed of short, intrafascicularly terminating fibers, while shorter fascicles comprised fibers spanning the entire fascicular length. This preliminary study provides evidence that multiple endplate bands are contained in some regions of the abdominal muscles, an arrangement that differs from most human appendicular muscles. It is not clear whether the variations in the described fine architectural features reflect regional differences in muscle function. Clin. Anat. 20:808–813, 2007. © 2007 Wiley‐Liss, Inc.
Study on the Building of Administrative Monopoly Evaluation Index System——Taken Toll Road Industry of China as an Example

The paper takes the construction of the index system of Administrative monopoly in toll road industry as the research core. According to the industry attribute, the paper, clusters the eight infrastructure industry which feature the administrative monopoly characteristics by applying the dynamic clustering method. The paper also uses the distance discrimination to identify the toll road industry category. Taking the measure index of the same category industry as reference, the paper build the index system which has characteristics of toll roads industry and can scientifically define monopoly's degree based on SPRCP. Finally, the paper uses the index system which has 16 indexes to empirically evaluate the degree of administrative monopoly and compared the result with other industries' result. Through the analysis further, it proves the rationality of this index system and indicates the direction for managing the irrational administrative monopoly of toll road industry.
The roles of Wnt antagonists Dkk1 and sFRP4 during adipogenesis of human adipose tissue‐derived mesenchymal stem cells

Abstract. Objectives: The canonical Wnt signalling pathway performs an important function in the control of adipogenesis. However, the mechanisms and mediators underlying these interactions have yet to be defined in detail. Thus, this study was performed in order to elucidate the roles of the Wnt family during adipogenic differentiation of human adipose tissue‐derived mesenchymal stem cells (hAMSCs). Materials and methods: We assessed several members of the Frizzled (FZD) family, the receptors of Wnts, inhibitors including the secreted frizzled‐related protein (sFRP) family and Dickkopfs (Dkks), and the downstream factor, β‐catenin. Expressional levels of adipogenic markers regulated by the small interfering RNA of Dkk1 (siDkk1) and sFRP4 (sisFRP4) were assessed using real‐time quantitative PCR and Western blot analysis. Results: The mRNA level of Dkk1 was expressed abundantly in the early stages of adipogenesis and decreased rapidly during the late stages of adipogenesis. However, sFRP4 mRNA was up‐regulated gradually during adipogenic differentiation in hAMSCs. Expression of FZD1, FZD7 and β‐catenin were reduced during adipogenic differentiation. Transfection of hAMSCs with siDkk1 or sisFRP4 partially inhibited differentiation of hAMSCs into adipocytes and restored levels of β‐catenin. Conclusions: We determined that Dkk1 was up‐regulated transiently in the early stages of adipogenesis, and that sFRP4 levels increased gradually during adipogeneis via inhibition of Wnt signalling. Collectively, these results show that Dkk1 and sFRP4 perform an important function in adipogenesis in hAMSCs.
Male dominance and reproductive success in wild white‐faced capuchins (Cebus capucinus) at Lomas Barbudal, Costa Rica

Theory and a growing body of empirical evidence suggest that higher ranking males experience reproductive advantages in group‐living mammals. White‐faced capuchins (Cebus capucinus) exhibit an interesting social system for investigating the relationship between dominance and reproductive success (RS) because they live in multimale multifemale social groups, in which the alpha males can have extraordinarily long tenures (i.e. they coreside with daughters of reproductive age). Genetic paternity was determined from fecal samples for 120 infants born into three social groups of wild C. capucinus at Lomas Barbudal Biological Reserve, Costa Rica. Alpha males produced far more offspring than expected by chance, and significantly high Nonac's B indices (a measure of deviation from a random distribution of RS among potentially breeding individuals) were a feature of six out of eight male tenures. The likelihood of the alpha male siring a particular offspring was predicted by the kin relationship between the mother and the alpha male, as well as the total number of males and females in the group. The almost complete lack of father–daughter inbreeding [Muniz et al., 2006] constitutes an impediment to alpha male reproductive monopolization in this population, particularly toward the end of long alpha male tenures. Am. J. Primatol. 72:1118–1130, 2010. © 2010 Wiley‐Liss, Inc.