Miracle-dz/UniFAR-FTUs huggingface dataset:
On the development of a Multi-tier, Multimodal Wireless Sensor Network for wild life monitoring

Brazilian forests and Savannas have a rich biodiversity that still needs to be known, monitored and protected. Distributed sensing tools such as the wireless sensor networks are a natural solution. These networks have evolved quickly in recent years leading to specializations such as wireless visual sensor networks and wireless multi-tier, multimodal sensor networks, sensor networks distributed over several tier, using more than one sensing modality. This work presents the design and implementation of a multi-tier, multimodal application employing infrared and visual sensors to environmental monitoring in remote areas. A prototype using commercial off-the-shelf nodes and sensors is also implemented and some experiments are performed.
Is a target culture in health care always compatible with efficient use of resources? A cost-effectiveness analysis of an intervention to achieve thrombolysis targets.

BACKGROUND The UK government has attempted to improve the quality of health care in the National Health Service and minimize geographical variations in quality by imposing targets in certain areas of health care. The measures taken by local health economies to achieve these targets have not before been subjected to cost-effectiveness analysis. We have assessed the cost effectiveness of an intervention designed to achieve thrombolysis time targets. METHODS In the setting of a single district general hospital in England, we audited local pain-to-needle (PTN) and door-to-needle (DTN) times, before and after a pounds 208,000 (Euro 310,000, dollar 370,000) annual expenditure to improve performance against government targets. The intervention included the recruitment of additional nursing time in the Accident & Emergency Department and the use of a single bolus thrombolytic agent for all patients with ST elevation myocardial infarction. An economic evaluation was performed, based on the expected number of additional lives saved, extrapolated from a meta-analysis of previous thrombolysis trials. RESULTS The intervention reduced mean DTN time from 37.6 +/- 5.9 minutes (mean +/- SEM) to 27.6 +/- 3.6 minutes (p = 0.06). The cost per life saved was pounds 3,423 +/- 850 (Euro 5,100,000, dollar 6,100,000), the cost per life year gained was pounds 222,184 (Euro 330,000, dollar 390,000) and the cost per quality-adjusted life year (QALY) gained was pounds 246,871 (Euro 370,000, dollar 440,000). CONCLUSION Although moderately successful at improving performance against government targets, this intervention to promote rapid thrombolysis proved to be an inefficient use of health-care resources. Strict government targets in health care may not always lead to efficient targeting of resources.
Disparate Body Composition Outcomes for Underwater Weighing, Dual-Energy X-Ray Absorptiometry, and Two Bioelectrical Impedance Devices in Overweight Young Adults

Introduction: As the prevalence of obesity rises, so does the need for reliable Body Composition (BC) methods. Many methods of BC analysis exist, however validity between methods has been questioned. Uncertainty exists within the scientific literature about which laboratory method and field measurement is applicable for the overweight population to estimate Percent Body Fat (% BF). There is scarce research comparing Hydrostatic Weighing (HW) and Dual Energy X-Ray Absorptiometry (DXA) with field methods in overweight individuals. The purpose of this study was to compare HW and DXA with Multi-Frequency (MF-BIA) and a Single-Frequency (SFBIA) Bioelectrical Impedance (BIA) device. Methods: Twenty-five overweight and obese adults (BMI 30.1 ± 4.1 kg/ m2, 13 males, 12 females, ages 24.6 ± 4.7y) were randomly assessed by vertical SF-BIA, and supine MF-BIA against DXA and lastly HW. All participants followed standardized pre-testing guidelines for BC assessment. Agreement was assessed using a 2 (group) x 4 (method) RMANOVA and post-hoc t-tests were applied as appropriate. All methods of body composition were used and compared to DXA and HW. You can submit your Manuscripts at: https://symbiosisonlinepublishing.com/submitManuscript.php
A new method for the rapid measurement of body composition in critically ill surgical patients

A rapid, non‐invasive method for the measurement of obsolute amounts of fat, protein, minerals and water in the body has been developed which is applicable to very ill patients. The patients is weighed and skinfold thickness is measured with calipers. The body contents of potassium, nitrogen, sodium, chlorine, calcium and phosphorus are measured in a whole‐body radiation counter after irradiation with fast neutrons. From these values absolute amounts of body fat, protein, minerals and water are calculated. The procedure, which takes about 40 min, is carried out with the patient lying supine on a couch. The errors in the absolute measurement of the components expressed as percentages of body weight are: for fat, 4.5 per cent; for protein, 1.6 per cent; for minerals, 0.8 per cent; and for water, 4.9 per cent. The radiation dose is equivalent to that of a chest radiograph (50 mrem).
Calcitonin and Amylin Receptor Peptide Interaction Mechanisms

Receptor activity-modifying proteins (RAMP1–3) determine the selectivity of the class B G protein-coupled calcitonin receptor (CTR) and the CTR-like receptor (CLR) for calcitonin (CT), amylin (Amy), calcitonin gene-related peptide (CGRP), and adrenomedullin (AM) peptides. RAMP1/2 alter CLR selectivity for CGRP/AM in part by RAMP1 Trp-84 or RAMP2 Glu-101 contacting the distinct CGRP/AM C-terminal residues. It is unclear whether RAMPs use a similar mechanism to modulate CTR affinity for CT and Amy, analogs of which are therapeutics for bone disorders and diabetes, respectively. Here, we reproduced the peptide selectivity of intact CTR, AMY1 (CTR·RAMP1), and AMY2 (CTR·RAMP2) receptors using purified CTR extracellular domain (ECD) and tethered RAMP1- and RAMP2-CTR ECD fusion proteins and antagonist peptides. All three proteins bound salmon calcitonin (sCT). Tethering RAMPs to CTR enhanced binding of rAmy, CGRP, and the AMY antagonist AC413. Peptide alanine-scanning mutagenesis and modeling of receptor-bound sCT and AC413 supported a shared non-helical CGRP-like conformation for their TN(T/V)G motif prior to the C terminus. After this motif, the peptides diverged; the sCT C-terminal Pro was crucial for receptor binding, whereas the AC413/rAmy C-terminal Tyr had little or no influence on binding. Accordingly, mutant RAMP1 W84A- and RAMP2 E101A-CTR ECD retained AC413/rAmy binding. ECD binding and cell-based signaling assays with antagonist sCT/AC413/rAmy variants with C-terminal residue swaps indicated that the C-terminal sCT/rAmy residue identity affects affinity more than selectivity. rAmy(8–37) Y37P exhibited enhanced antagonism of AMY1 while retaining selectivity. These results reveal unexpected differences in how RAMPs determine CTR and CLR peptide selectivity and support the hypothesis that RAMPs allosterically modulate CTR peptide affinity.
Cellular nucleic acid binding protein binds G‐rich single‐stranded nucleic acids and may function as a nucleic acid chaperone

Cellular nucleic acid binding protein (CNBP) is a small single‐stranded nucleic acid binding protein made of seven Zn knuckles and an Arg‐Gly rich box. CNBP is strikingly conserved among vertebrates and was reported to play broad‐spectrum functions in eukaryotic cells biology. Neither its biological function nor its mechanisms of action were elucidated yet. The main goal of this work was to gain further insights into the CNBP biochemical and molecular features. We studied Bufo arenarum CNBP (bCNBP) binding to single‐stranded nucleic acid probes representing the main reported CNBP putative targets. We report that, although bCNBP is able to bind RNA and single‐stranded DNA (ssDNA) probes in vitro, it binds RNA as a preformed dimer whereas both monomer and dimer are able to bind to ssDNA. A systematic analysis of variant probes shows that the preferred bCNBP targets contain unpaired guanosine‐rich stretches. These data expand the knowledge about CNBP binding stoichiometry and begins to dissect the main features of CNBP nucleic acid targets. Besides, we show that bCNBP presents a highly disordered predicted structure and promotes the annealing and melting of nucleic acids in vitro. These features are typical of proteins that function as nucleic acid chaperones. Based on these data, we propose that CNBP may function as a nucleic acid chaperone through binding, remodeling, and stabilizing nucleic acids secondary structures. This novel CNBP biochemical activity broadens the field of study about its biological function and may be the basis to understand the diverse ways in which CNBP controls gene expression. J. Cell. Biochem. 103: 1013–1036, 2008. © 2007 Wiley‐Liss, Inc.
Linkage Study of Schizophrenia Candidate Regions on Chromosomes 5 q , 6 q , 10 p , and 13 q : Schizophrenia Linkage Collaborative Group III *

Department of Psychiatry, University of Pennsylvania, Philadelphia; 2 Department of Psychiatry, Washington University, St. Louis; Department of Psychiatry and Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond; Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine, Cardiff; Department of Psychiatry, University of Bonn, Bonn; Department of Psychiatry, University of Chicago, Chicago; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore; Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératif, Centre National de la Récherche Scientifique, Hôpital de la Pitié Salpêtrière, and Aventis SA, Paris; The Health Research Board, Dublin; Department of Psychiatry, HadassahHebrew University Medical Center, Jerusalem; Department of Psychiatry, University of Queensland and Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Brisbane; and Department of Genetics, University of Geneva Medical School, Geneva
Interaction with Polyglutamine-expanded Huntingtin Alters Cellular Distribution and RNA Processing of Huntingtin Yeast Two-hybrid Protein A (HYPA)*

Huntington disease (HD) is an autosomal inherited disorder that causes the deterioration of brain cells. The polyglutamine (polyQ) expansion of huntingtin (Htt) is implicated in the pathogenesis of HD via interaction with an RNA splicing factor, Htt yeast two-hybrid protein A/forming-binding protein 11 (HYPA/FBP11). Besides the pathogenic polyQ expansion, Htt also contains a proline-rich region (PRR) located exactly in the C terminus to the polyQ tract. However, how the polyQ expansion influences the PRR-mediated protein interaction and how this abnormal interaction leads to the biological consequence remain elusive. Our NMR structural analysis indicates that the PRR motif of Htt cooperatively interacts with the tandem WW domains of HYPA through domain chaperoning effect of WW1 on WW2. The polyQ-expanded Htt sequesters HYPA to the cytosolic location and then significantly reduces the efficiency of pre-mRNA splicing. We propose that the toxic gain-of-function of the polyQ-expanded Htt that causes dysfunction of cellular RNA processing contributes to the pathogenesis of HD.
PK‐LR gene mutations in pyruvate kinase deficient Portuguese patients

In nine unrelated Portuguese patients with pyruvate kinase (PK) deficient anaemia, whose symptoms ranged from a mild chronic haemolytic anaemia to a severe anaemia presenting at birth and requiring multiple transfusions, the PK‐LR gene mutations were identified and correlated with their phenotypes. Five different mutations were identified, three of them for the first time: a missense mutation 1670G → C on exon 12 and two 5′ splice donor site (GT) mutations on intron 8 [IVS8(+2)T → G] and intron 10 [IVS10(+1)G → C]. Two previously described missense mutations, 1456C → T and 993C → A, were also found. The genotype/phenotype correlation showed that patients with two missense mutations or with a missense mutation and a splicing mutation had a mild haemolytic anaemia. The three patients with severe anaemia, who were transfusion dependent until splenectomy, were homozygous for the splicing site mutations IVS10(+1)G → C or IVS8(+2)T → G.
A novel HLA‐B*40 allele, B*40:01:40, identified in a Chinese individual

A new allele, officially named B*40:01:40, was detected in a Chinese individual by sequence‐based typing (SBT). The new allele differs from B*40:01:01 by a single nucleotide exchange at position 99 in codon 9, which results in synonymous substitution and seems not to compromise the HLA complex and T‐cell receptor interaction.
Applied adaptive fuzzy-neural inference models: complexity and integrity problems

This paper explores aspects of computational complexity versus rule reduction and of integrity preservation versus optimally index, which have become an issue of considerable concern in learning techniques for adaptive fuzzy inference models. In control oriented applications of adaptive fuzzy inference systems, implemented as fuzzy-neural networks, a balanced observation of these conflicting requirements appeared important for a good yet feasible application design. The focus is confined to a family of adaptive fuzzy inference systems that can be interpreted as a partially connected multilayer feedforward neural networks employing Gaussian activation function. The knowledge base rules are designed implying the connections are a priori fixed, and then the respective strengths adapted on the grounds of input and output data sets. Information granulation plays a significant role too. These as well as membership-function parameters ought to be adapted in a learning-training process via the minimization of an appropriate error function.
Bilişim Liderliği Ölçeği: Bir Ölçek Geliştirme Çalışması

Yasadigimiz dunya surekli degisim ve gelisim sureci olarak tanimlanabilir. Bilisim ise gunumuzun onemli kavramlarindandir. Arastirmanin amaci “Bilisim Liderligi” ile ilgili algilari olcen gecerli ve guvenilir bir olcek olusturmaktir. Calismada, nitel ve nicel arastirma yonteminin bir arada kullanildigi karma arastirma deseni uygulanmistir. Olcek % 79.315 oraninda bir varyansla aciklanmaktadir. Guvenirlik degeri . 97 bulunmustur. Dogrulayici faktor analizi sonuclarinin da iyi gostergeleri yansittigi gorulmektedir. Calismada gelistirilen bilisim liderligi olcegi ile mevcut alanyazina ve gelecekte yapilacak calismalara onemli katkilar saglanacagi dusunulmektedir.
A 2.4-GHz 20–40-MHz Channel WLAN Digital Outphasing Transmitter Utilizing a Delay-Based Wideband Phase Modulator in 32-nm CMOS

A digital outphasing transmitter is presented for 2.4-GHz WiFi. The transmitter consists of two delay-based phase modulators and a 26-dBm integrated switching class-D power amplifier. The delay-based phase modulator delays incoming LO edges with a resolution of 1.4 ps (8 bit) required to meet WiFi requirements. A phase MUX architecture is proposed to implement switching between phases once every LO period (2.4 GHz) without generating detrimental glitches at the output. Due to its open-loop nature, the proposed phase modulator is capable of delivering wide OFDM bandwidths up to 40 MHz. The paper analyzes the impact of impairments, e.g., delay mismatch within the delay cells and outphasing mismatches, as well as associated mitigation techniques. The transmitter has been implemented in a 32-nm digital CMOS process and delivers an OFDM average power of 20 dBm with an overall system efficiency of 18.6% when transmitting 54-Mb/s 64QAM signal. The fully digital design is expected to further improve in power dissipation and chip-area with further CMOS scaling.
Bandwidth and the creation of awareness

office, for the same reasons—anarchy and entropy— that make search critical for the Internet. Today, we might search for our missing packages, identify the location of an airplane, and find our misplaced cordless phone. But as we deepen the integration of the virtual and physical worlds, we’ll extend the power of search. Research at Berkeley and Xerox PARC reveals that we can create interactive labels at low cost using essentially a fancy inkjet printer that prints circuits and that we can build tiny networked sensors and actuators (“smart dust”) using integrated-circuit technology. Simple uses include tracking physical objects, labels that refer you to a more detailed Web site, and price/feature comparisons. Books and files would know if they are in the right place, and, in general, inventory management would be simpler and more powerful. I would finally get that search engine for my office.
Novel Magnetic Technology for Intraoperative Intracranial Frameless Navigation: In Vivo and in Vitro Results

OBJECTIVE To characterize the accuracy of the Magellan electromagnetic navigation system (Biosense Webster, Tirat HaCarmel, Israel) and to demonstrate the feasibility of its use in image-guided neurosurgical applications. DESCRIPTION OF INSTRUMENTATION The Magellan system was developed to provide real-time tracking of the distal tips of flexible catheters, steerable endoscopes, and other surgical instruments, using ultra-low electromagnetic fields and a novel miniature position sensor for image-correlated intraoperative navigation and mapping applications. METHODS An image registration procedure was performed, and static and qualitative accuracies were assessed in a series of phantom, animal, and human neurosurgical studies. EXPERIENCE AND RESULTS During the human study phase, an accuracy error of up to 5 mm was deemed acceptable. Results demonstrated that this degree of accuracy was maintained throughout all procedures. All anatomic landmarks were reached with precision and were accurately viewed on the display screen. Navigation that relied on the system was also successful. No interference with operating room equipment was noted. The accuracy of the system was maintained during regular surgical procedures, using standard surgical tools. CONCLUSION The system provides precise lesion localization without limiting the line of vision, the mobility of the surgeon, or the flexibility of instruments. Electromagnetic navigation promises new advances in neuronavigation and frameless stereotactic surgery.
White‐coat hypertension

Numerous studies have examined whether white‐coat hypertension (WCHT) is associated with increased cardiovascular risk, but with definitions of WCHT that were not sufficiently robust, results have been inconsistent. The aim of the present review was to standardize the evidence by only including studies that used a definition of WCHT consistent with international guidelines. Published studies were reviewed for data on vascular dysfunction, target organ damage, risk of future sustained hypertension and cardiovascular events. White‐coat hypertension has a population prevalence of approximately 15% and is associated with non‐smoking and slightly elevated clinic blood pressure. Compared with normotensives, subjects with WCHT are at increased cardiovascular risk due to a higher prevalence of glucose dysregulation, increased left ventricular mass index and increased risk of future diabetes and hypertension. In conclusion, management of a patient with WCHT should focus on cardiovascular risk factors, particularly glucose intolerance, not blood pressure alone.
Rethinking the Post-Secular and Secular with Habermas and Ambedkar

Die liberale These der Sakularisation trennt Religion und Staat, um religiosen Dogmatismus zu bekampfen. Daneben besagt diese These, dass Religion im offentlichen Raum irrelevant wird, wenn sie durch die Wissenschaft, durch Politik und durch die Logik der Verwaltung ersetzt wird. Die Grenzen dieser These sind, im Zusammenhang mit der Ruckkehr der Religion – haufig in der Form des Extremismus – in den offentlichen Raum in jungerer Zeit, eingehend diskutiert worden. Habermas’ Konzept des „Postsakularen“ nimmt diesen Tatbestand auf und bedenkt das Verhaltnis von Religion und Politik. Jedoch gelingt es Habermas nicht, uber das binare Schema von Zivilgesellschaft und Staat hinauszugelangen. Dies liegt an seiner Betonung der Diskursivitat (wie Cooke konstatiert) und an seiner Konzentration auf den europaischen Kontext der Sakularisierung. Es ware erhellend fur Habermas, wenn er einen Blick auf den Kontext der indischen Diskussion uber die Sakularisierung werfen wurde, um von dort aus zur Frage der Moglichkeit eines Dialogs zwischen Religion und Politik zu gelangen. Das indische Gesetz definiert Sakularitat in enger Verbindung mit Religion und formuliert zugleich die Moglichkeit der Reform von Religion. Jedoch haben die Diskussionen in Indien die aktive Rolle ausgeblendet, die Ambedkar spielt, wenn er die Kritik in die Religion einfuhrt und Kastendiskriminierung mit fehlender religioser Harmonie in Zusammenhang bringt. Ambedkar verortete Kasten- und Geschlechtsungleichheit in den dogmatischen religiosen Praktiken und den Doktrinen des Hinduismus. Konsequenterweise war fur Ambedkar Religion zugleich die Basis fur soziale Ungleichheit und der Weg ihrer Beseitigung. Dies wiederum lag an ihrem sozialen und offentlichen Charakter. Indem Ambedkar Kritik, Vernunft und nichtdiskursive Erkenntnis in den offentlichen Raum einfuhrt, bietet er einen Weg aus jener Sackgasse, in der sich Habermas bezuglich der Integration von Religion und Politik befindet.
Analysis of Noise Uncertainty and Frequency Selectivity Effects in Wideband Multimode Spectrum Sensing

The present work is devoted to the comprehensive analysis of the detrimental effects of noise uncertainty in wide-band multimode subband based spectrum sensing over frequency selective channels. Unlike existing analyses that are mostly limited to single-band detection, an analytical model is firstly formulated for the case of wide-band multimode subband based spectrum sensing, considering both noise uncertainty and frequency selectivity. This model is also extended for the case of detecting a reappearing primary user (PU), as well as for the sensing scenarios where the frequency range of a PU is unknown. Novel closed-form expressions are derived for the corresponding probabilities of false alarm and probabilities of detection. The derived expressions are subsequently employed in quantifying the effects of noise uncertainty and frequency selectivity. A subband based scheme for the sensing of multi-channel primary systems is presented and analyzed. The proposed method is found to exhibit significantly reduced sensing time and greatly improved robustness against noise uncertainty compared to the basic wideband energy detection method.
Bi-Directional Signal Detection and Decoding for Hybrid ARQ Using Superposition Coding

This paper proposes a bi-directional signal detection and decoding method for our previously proposed hybrid automatic repeat request (HARQ) scheme using superposition coding (SPC-HARQ). The SPC-HARQ scheme multiplexes the initial and retransmission packets within the same frequency band using superposition coding to improve the transmission efficiency at retransmission. Since the superposition coding in the SPC-HARQ can be viewed as packet-level convolutional coding, the receiver can detect and decode the series of received packets in the reverse order of the time slots in addition to the forward order, that is, bi-directional detection and decoding. Simulation results show that the proposed bi-directional signal detection and decoding in the SPC-HARQ improves the throughput performance compared to when using the conventional HARQ and SPC-HARQ with forward decoding only.