Miracle-dz/UniFAR-FTUs huggingface dataset:
Improving Pharmacists’ Targeting of Patients for Medication Review and Deprescription

Background: In an acute hospital setting, a multi-disciplinary approach to medication review can improve prescribing and medicine selection in patients with frailty. There is a need for a clear understanding of the roles and responsibilities of pharmacists to ensure that interventions have the greatest impact on patient care. Aim: To use a consensus building process to produce guidance for pharmacists to support the identification of patients at risk from their medicines, and to articulate expected actions and escalation processes. Methods: A literature search was conducted and evidence used to establish a set of ten scenarios often encountered in hospitalised patients, with six or more possible actions. Four consultant physicians and four senior pharmacists ranked their levels of agreement with the listed actions. The process was redrafted and repeated until consensus was reached and interventions were defined. Outcome: Generalised guidance for reviewing older adults’ medicines was developed, alongside escalation processes that should be followed in a specific set of clinical situations. The panel agreed that both pharmacists and physicians have an active role to play in medication review, and face-to-face communication is always preferable to facilitate informed decision making. Only prescribers should deprescribe, however pharmacists who are not also trained as prescribers may temporarily “hold” medications in the best interests of the patient with appropriate documentation and a follow up discussion with the prescribing team. The consensus was that a combination of age, problematic polypharmacy, and the presence of medication-related problems, were the most important factors in the identification of patients who would benefit most from a comprehensive medication review. Conclusions: Guidance on the identification of patients on inappropriate medicines, and subsequent pharmacist-led intervention to prompt and promote deprescribing, has been developed for implementation in an acute hospital.
Pre-training of Context-aware Item Representation for Next Basket Recommendation

Next basket recommendation, which aims to predict the next a few items that a user most probably purchases given his historical transactions, plays a vital role in market basket analysis. From the viewpoint of item, an item could be purchased by different users together with different items, for different reasons. Therefore, an ideal recommender system should represent an item considering its transaction contexts. Existing state-of-the-art deep learning methods usually adopt the static item representations, which are invariant among all of the transactions and thus cannot achieve the full potentials of deep learning. Inspired by the pre-trained representations of BERT in natural language processing, we propose to conduct context-aware item representation for next basket recommendation, called Item Encoder Representations from Transformers (IERT). In the offline phase, IERT pre-trains deep item representations conditioning on their transaction contexts. In the online recommendation phase, the pre-trained model is further fine-tuned with an additional output layer. The output contextualized item embeddings are used to capture users' sequential behaviors and general tastes to conduct recommendation. Experimental results on the Ta-Feng data set show that IERT outperforms the state-of-the-art baseline methods, which demonstrated the effectiveness of IERT in next basket representation.
Using Gazetteers to Annotate Geographic Catalog Entries

A gazetteer is a geographical dictionary containing a list of geographic names, together with their geographic locations and other descriptive information. A geographic metadata catalog holds metadata describing geographic information resources, stored in a wide variety of sources, ranging from the researchers' personal computers to large public databases. This paper argues that unique characteristics of geographic objects can be explored to address the problem of automating the generation of metadata for geographic information resources. The paper considers federations of gazetteers and geographic metadata catalogs and discusses in detail two problems, namely, how to use gazetteers to automate the description of geographic information resources and how to align thesauri used by gazetteers. The paper also argues why such problems are important in the context of a federated architecture.
A Probabilistic Setting and Lexical Coocurrence Model for Textual Entailment

This paper proposes a general probabilistic setting that formalizes a probabilistic notion of textual entailment. We further describe a particular preliminary model for lexical-level entailment, based on document cooccurrence probabilities, which follows the general setting. The model was evaluated on two application independent datasets, suggesting the relevance of such probabilistic approaches for entailment modeling.
Characterization of Extrafocal Dose Influence on the Out-of-field Dose Distribution by Monte Carlo Simulations and Dose Measurements.

Out-of-field scattered and transmitted extrafocal radiation may induce secondary cancer in long-term survivors of external radiotherapy. Pediatric patients have higher life expectancy and tend to receive higher secondary radiation damage due to geometric and biological factors. The goal of this study is to characterize the location and the magnitude of extrafocal dose regions in the case of three-dimensional conformal radiotherapy and volumetric arc therapy, to apply this information to clinical treatment cases, and to provide mitigation strategies. Extrafocal dose has been investigated in a Varian TrueBeam linac equipped with a High-Definition 120 multileaf collimator using different physical and virtual phantoms, dose calculation (including Monte Carlo techniques), and dose measurement methods. All Monte Carlo calculations showed excellent agreement with measurements. Treatment planning system calculations failed to provide reliable results out of the treatment field. Both Monte Carlo calculations and dose measurements showed regions with higher dose (extrafocal dose areas) when compared to the background. These areas start to be noticeable beyond 11 cm from the isocenter in the direction perpendicular to the multileaf collimator leaves' travel direction. Out-of-field extrafocal doses up to 160% of the mean dose transmitted through the closed multileaf collimator were registered. Two overlapping components were observed in the extrafocal distribution: the first is an almost elliptical blurred dose distribution, and the second is a well-defined rectangular dose distribution. Extra precautions should be taken into consideration when treating pediatric patients with a High-Definition 120 multileaf collimator to avoid directing the extrafocal radiation into a radiosensitive organ during external beam therapy.
BMP-2-releasing gelatin microspheres/PLGA scaffolds for bone repairment of X-ray-radiated rabbit radius defects

Abstract The purpose of this research is to assess the feasibility of poly(lactic-co-glycolic) acid (PLGA) incorporating gelatin microspheres (PLGA/GMs scaffold) for enhancing osteogenesis in vitro and at a radius defect of rabbits after X-ray radiation in vivo. After incorporating gelatin microspheres, PLGA scaffold demonstrated improved mechanical properties. Moreover, a sustained release property of recombinant human bone morphogenetic protein-2 (BMP-2) was achieved in BMP-2-releasing PLGA/GMs scaffold. BMP-2-releasing PLGA/GMs scaffold also enhanced proliferation and osteogenesis of rabbit bone mesenchymal stem cells (BMSCs) in vitro, indicating the bioactivity of BMP-2. After finishing X-ray radiation of the radius bone, 20-mm radius bone defects were generated, followed by being implanted with BMP-2-releasing PLGA/GMs scaffolds with or without bone marrow. Both PLGA/GMs scaffolds containing bone marrow or BMP-2 showed more obvious enhancement for bone regeneration than the empty scaffolds (control) at the radius defect. In the X-ray radiated groups, however, the bone regeneration was inhibited either with bone marrow or BMP-2. When combined with bone marrow, the BMP-2 showed significantly high osteogenic effect, regardless of X-ray radiation. It is considered that it is a promising way to repair bone defects even after X-ray radiation by a combination of bone marrow with the BMP-2-releasing PLGA/GMs scaffold.
Text Classification Components for Detecting Descriptions and Names of CAD models

We apply text analysis approaches for a specialized search engine for 3D CAD models and associated products. The main goals are to distinguish between actual product descriptions and other text on a website, as well as to decide whether a given text is or contains a product name. For this we use paragraph vectors for text classification, a character-level long short-term memory network (LSTM) for a single word classification and an LSTM tagger based on word embeddings for detecting product names within sentences. Despite the need to collect bigger datasets in our specific problem domain, the first results are promising and partially fit for production use.
The effects of electrical field spatial spread and some cognitive factors on speech-in-noise performance of individual cochlear implant users—A computer model study

The relation of the individual speech-in-noise performance differences in cochlear implant (CI) users to underlying physiological factors is currently poorly understood. This study approached this research question by a step-wise individualization of a computer model of speech intelligibility mimicking the details of CI signal processing and some details of the physiology present in CI users. Two factors, the electrical field spatial spread and internal noise (as a coarse model of the individual cognitive performance) were incorporated. Internal representations of speech-in-noise mixtures calculated by the model were classified using an automatic speech recognizer backend employing Hidden Markov Models with a Gaussian probability distribution. One-dimensional electric field spatial spread functions were inferred from electrical field imaging data of 14 CI users. Simplified assumptions of homogenously distributed auditory nerve fibers along the cochlear array and equal distance between electrode array and nerve tissue were assumed in the model. Internal noise, whose standard deviation was adjusted based on either anamnesis data, or text-reception-threshold data, or a combination thereof, was applied to the internal representations before classification. A systematic model evaluation showed that predicted speech-reception-thresholds (SRTs) in stationary noise improved (decreased) with decreasing internal noise standard deviation and with narrower electric field spatial spreads. The model version that was individualized to actual listeners using internal noise alone (containing average spatial spread) showed significant correlations to measured SRTs, reflecting the high correlation of the text-reception threshold data with SRTs. However, neither individualization to spatial spread functions alone, nor a combined individualization based on spatial spread functions and internal noise standard deviation did produce significant correlations with measured SRTs.
Physician Consultations, Prostate Cancer Knowledge, and PSA Screening of African American Men in the Era of Shared Decision-Making

African American (AA)/Black men are more likely to develop aggressive prostate cancer (PCa), yet less likely to be screened despite guidelines espousing shared decision-making regarding PCa screening and prostate-specific antigen (PSA) testing. Given the documented racial disparities in PCa incidence and mortality, engaging interactions with physicians are especially important for AA/Black men. Thus, this study evaluated occurrence of physician–patient conversations among AA/Black men, and whether such conversations were associated with PCa knowledge. We also quantified the serum PSA values of participants who had, and had not, discussed testing with their physicians. Self-identified AA/Black men living in California and New York, ages 21–85, donated blood and completed a comprehensive sociodemographic and health survey (n = 414). Less than half (45.2%) of participants had discussed PCa screening with their physicians. Multivariate analyses were used to assess whether physician–patient conversations predicted PCa knowledge after adjusting for key sociodemographic/economic and health-care variables. Increased PCa knowledge was correlated with younger age, higher income and education, and having discussed the pros and cons of PCa testing with a physician. Serum PSA values were measured by ELISA. Higher-than-normal PSA values were found in 38.5% of men who had discussed PCa screening with a physician and 29.1% who had not discussed PCa screening. Our results suggest that physician–AA/Black patient conversations regarding PCa risk need improvement. Encouraging more effective communication between physicians and AA/Black men concerning PCa screening and PSA testing has the potential to reduce PCa health disparities.
The influence of intensity standardization on medical image registration

Acquisition-to-acquisition signal intensity variations (non-standardness) are inherent in MR images. Standardization is a post processing method for correcting inter-subject intensity variations through transforming all images from the given image gray scale into a standard gray scale wherein similar intensities achieve similar tissue meanings. The lack of a standard image intensity scale in MRI leads to many difficulties in tissue characterizability, image display, and analysis, including image segmentation. This phenomenon has been documented well; however, effects of standardization on medical image registration have not been studied yet. In this paper, we investigate the influence of intensity standardization in registration tasks with systematic and analytic evaluations involving clinical MR images. We conducted nearly 20,000 clinical MR image registration experiments and evaluated the quality of registrations both quantitatively and qualitatively. The evaluations show that intensity variations between images degrades the accuracy of registration performance. The results imply that the accuracy of image registration not only depends on spatial and geometric similarity but also on the similarity of the intensity values for the same tissues in different images.
Brain Structural Correlates of Risk-Taking Behavior and Effects of Peer Influence in Adolescents

Adolescents are characterized by impulsive risky behavior, particularly in the presence of peers. We discriminated high and low risk-taking male adolescents aged 18–19 years by assessing their propensity for risky behavior and vulnerability to peer influence with personality tests, and compared structural differences in gray and white matter of the brain with voxel-based morphometry (VBM) and diffusion tensor imaging (DTI), respectively. We also compared the brain structures according to the participants' actual risk-taking behavior in a simulated driving task with two different social conditions making up a peer competition situation. There was a discrepancy between the self-reported personality test results and risky driving behavior (running through an intersection with traffic lights turning yellow, chancing a collision with another vehicle). Comparison between high and low risk-taking adolescents according to personality test results revealed no significant difference in gray matter volume and white matter integrity. However, comparison according to actual risk-taking behavior during task performance revealed significantly higher white matter integrity in the high risk-taking group, suggesting that increased risky behavior during adolescence is not necessarily attributed to the immature brain as conventional wisdom says.
Leave Lamarck Alone! Why the Use of the Term “Lamarckism” and Its Cognates Must Be Shunned

abstract:Many scholars avoid the use of the term “Darwinism. ” It is not ideal, even to refer to Darwin’s own complex and fluid thinking about evolution, let alone to modern transformations of his ideas. The addition of the prefix neo- for those modern transformations does not solve the terminological problem. The same argument can be made for Lamarckism and its cognates: they are not ideal or meaningful labels to refer to Lamarck’s heterogeneous ideas. Lamarck’s name is even less appropriate as a label for modern developments in biology and, particularly, for the idea of the (presumed) inheritance of acquired characters. The dichotomous framing of modern thinking about evolution in terms of “Darwinian” and “Lamarckian” is especially confusing and un-helpful. Historians are obliged to use historical terms like “Lamarckism” or “Darwinism,” but philosophers and biologists should try to avoid using these terms and their cognates and learn to use more precise and less ambiguous, confusing, misleading, and emotionally charged words and phrases.
Functional Comparison for Lipid Metabolism and Intestinal and Fecal Microflora Enzyme Activities between Low Molecular Weight Chitosan and Chitosan Oligosaccharide in High-Fat-Diet-Fed Rats

The present study investigated and compared the regulatory effects on the lipid-related metabolism and intestinal disaccharidase/fecal bacterial enzyme activities between low molecular weight chitosan and chitosan oligosaccharide in high-fat-diet-fed rats. Diet supplementation of low molecular weight chitosan showed greater efficiency than chitosan oligosaccharide in suppressing the increased weights in body and in liver and adipose tissues of high-fat-diet-fed rats. Supplementation of low molecular weight chitosan also showed a greater improvement than chitosan oligosaccharide in imbalance of plasma, hepatic, and fecal lipid profiles, and intestinal disaccharidase activities in high-fat-diet-fed rats. Moreover, both low molecular weight chitosan and chitosan oligosaccharide significantly decreased the fecal microflora mucinase and β-glucuronidase activities in high-fat-diet-fed rats. These results suggest that low molecular weight chitosan exerts a greater positive improvement than chitosan oligosaccharide in lipid metabolism and intestinal disaccharidase activity in high-fat-diet-induced obese rats.
Biomechanical evaluation of tendon connection with novel suture techniques.

PURPOSE Achilles tendon rupture is a severe injury with poor curative effect due to its anatomical characteristic and mechanical peculiarity. Internal fixation of limited loop (IFLL) with steel-wire has been applied on patients with tendon rupture to fix the broken ends before physical rehabilitation. The purpose of this study is to investigate the biomechanical property and radiological characteristic of such suture technique for the repairment of tendon rupture. METHODS Tendons of pigs' hint feet were separated for the biomechanical study. Suture surgery was performed according to the protocol of IFLL. Biomechanical Testing Machine was adopted to conduct the biomechanical tensile load examination. The maximal load, elastic modulus and tendon stiffness of the stitched tendons with or without reinforcement were examined. RESULTS The maximum tensile load of the stitched tendons using IFLL reached 1/4 of the uninjured tendon's maximum tensile load, indicating that such suture technique is capable of providing enough tension for the ruptured tendon. Surprisingly, tendons fixed with titanium wire showed the highest load tension, which was comparable to the undamaged tendon. Therefore, we found the biomechanical basis of using IFLL in effectively connecting the rupture ends of tendons. CONCLUSIONS In conclusion, we provide biomechanical evidence for the use of IFLL in treatment of Achilles tendon rupture, by providing enough strength for the ankle function. Such suture technique could help the patients with better rehabilitation and reduced in-hospital stay after Achilles tendon injury.
Regimen durability in HIV‐infected children and adolescents initiating first‐line antiretroviral therapy in a large public sector HIV cohort in South Africa

In April 2010, tenofovir and abacavir replaced stavudine in public sector first‐line antiretroviral therapy (ART) for children under 20 years old in South Africa. The association of both abacavir and tenofovir with fewer side effects and toxicities compared to stavudine could translate to increased durability of tenofovir or abacavir‐based regimens. We evaluated changes over time in regimen durability for paediatric patients 3–19 years of age at eight public sector clinics in Johannesburg, South Africa.
IS PART OF A SPECIAL ISSUE ENTITLED ‘MOLECULAR TECHNOLOGIES TO IMPROVE VEGETATIVELY PROPAGATED BANANA AND CASSAVA’ Development of expressed sequence tag and expressed sequence tag–simple sequence repeat marker resources for Musa acuminata

Background and aims Banana (Musa acuminata) is a crop contributing to global food security. Many varieties lack resistance to biotic stresses, due to sterility and narrow genetic background. The objective of this study was to develop an expressed sequence tag (EST) database of transcripts expressed during compatible and incompatible banana–Mycosphaerella fijiensis (Mf) interactions. Black leaf streak disease (BLSD), caused by Mf, is a destructive disease of banana. Microsatellite markers were developed as a resource for crop improvement. Methodology cDNA libraries were constructed from in vitro-infected leaves from BLSD-resistant M. acuminata ssp. burmaniccoides Calcutta 4 (MAC4) and susceptible M. acuminata cv. Cavendish Grande * Corresponding author’s e-mail address: robertmiller@unb.br Published by Oxford University Press on behalf of the Annals of Botany Company. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. AoB PLANTS http://aobplants.oxfordjournals.org/ AoB PLANTS 2012: pls030; doi:10.1093/aobpla/pls030, available online at www.aobplants.oxfordjournals.org & The Authors 2012 1 Naine (MACV). Clones were 5′-end Sanger sequenced, ESTs assembled with TGICL and unigenes annotated using BLAST, Blast2GO and InterProScan. Mreps was used to screen for simple sequence repeats (SSRs), with markers evaluated for polymorphism using 20 diploid (AA) M. acuminata accessions contrasting in resistance to Mycosphaerella leaf spot diseases. Principal results A total of 9333 high-quality ESTs were obtained for MAC4 and 3964 for MACV, which assembled into 3995 unigenes. Of these, 2592 displayed homology to genes encoding proteins with known or putative function, and 266 to genes encoding proteins with unknown function. Gene ontology (GO) classification identified 543 GO terms, 2300 unigenes were assigned to EuKaryotic orthologous group categories and 312 mapped to Kyoto Encyclopedia of Genes and Genomes pathways. A total of 624 SSR loci were identified, with trinucleotide repeat motifs the most abundant in MAC4 (54.1 %) and MACV (57.6 %). Polymorphism across M. acuminata accessions was observed with 75 markers. Alleles per polymorphic locus ranged from 2 to 8, totalling 289. The polymorphism information content ranged from 0.08 to 0.81. Conclusions This EST collection offers a resource for studying functional genes, including transcripts expressed in banana–Mf interactions. Markers are applicable for genetic mapping, diversity characterization and marker-assisted breeding.