Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence of testicular carcinoma, therapy and quality assesment.

OBJECTIVE This study aimed to demonstrate incidence, symptoms and therapy management of testicular cancer patients. Also we had evaluated significance of testicular tumor markers. PATIENTS AND METHODS The study was retrospective, clinical and manipulative, analytical and descriptive and covers the period from 01.01. 2000 to 31.12. 2008 with 58 male patients from 16 years upwards. For each patient, the data were analyzed from ambulance and hospital protocol on the Urology Clinic Sarajevo. RESULTS Incidence of testicular cancer among patients at the Urology Clinic clinical center Sarajevo is on the rise for the last three years (about 20%). Of the 58 patients with testicular cancer, 70% of patients were in age 20-39 years. 47% were patients with right side testicular cancer and 53% were left sided. Walter Reed Hospital tumor classification showed I 50%, IIa 10%, IIb 19% and III 21% of patients. The highest incidence of pathohistological reports showed mixed tumors 46%, seminoma 26%, yolk sack 2%, teratoma 2%, carcinoma embrionale 16%, dysgerminoma 5% and Laydig cell carcinoma 3%. Mixed, seminoma and carcinoma embirionale represents 90% of testicular tumors. betaHCG marker was positive in 53% of patients with seminoma and non seminoma 80%. CEA marker was positive only in 9% of all testicular cancer, LDH showed higher incidence with metastatic seminoma tumor. 27,5% of patients undergone retroperitoneal lymphadenectomy treatment, all patients had radical orchiectomy. CONCLUSION The common therapeutic procedure in the treatment of testicular tumors are surgical methods radical inguinal orchiectomy, chemotherapy (advanced stages of seminoma and all stages of non seminoma tumor and radiotherapy (early stage seminoma). AFP and betaHCG are excellent markers in the evaluation of surgical and oncology treatment of testicular tumor.
Intravesical Bacillus Calmette-Guérin for the treatment of superficial bladder cancer following hematopoietic stem cell transplantation

Bladder cancer is the seventh most common cancer in men worldwide and accounts for approximately 5–10% of all malignancies among men in Europe. Superficial transitional cell carcinoma (TCC) represents the most frequent type of bladder cancer and presents a high incidence of recurrence and progression [1]. The use of intravesical instillations with Bacillus Calmette-Guérin (BCG) is considered an efficacious treatment for TCC, either for prevention of recurrence and progression or for eradication of residual tumor after transurethral resection [2]. The antitumor activity of BCG is based on immunomodulatory processes, such as the stimulation of cytotoxic T lymphocytes (CTL) or of natural killer (NK) cells and the production of cytokines such as interferon-gamma (IFN-g). An intact immune system is therefore required for BCG antitumor activity [3]. Furthermore, BCG is a live, attenuated Mycobacterium bovis bacillus that maintains an immunostimulating action but also a decreased infection ability. Thus, BCG vaccine is contraindicated in immunocompromised patients, because of an increased risk of morbidity and sepsis [4]. We report herein on two patients having received hematopoietic stem cell transplantation (HSCT) for hematological malignancies and who underwent BCG instillations for the treatment of urothelial carcinoma. The first patient, a 55-year-old man, was treated in our Department for an acute myelomonocytic leukaemia with eosinophilia (AML4eo) and inversion of the chromosome 16 in the karyotype (inv16), diagnosed on July 2001. On February 2000 the patient had undergone transurethral resection of a papillary urothelial carcinoma, grade G1 and stage PTA. He received a chemotherapy regimen consisting of cytosine arabinoside and anthracycline for the AML, while on September 2001 he underwent transurethral resection of recurrent TCC grade G1, stage PTA. On October 2001 the patient received an autologous HSCT after conditioning with busulphan/melphalan. He achieved complete cytological and cytogenetic remission. Afterwards, he received three cures of intravenous interleukin-2 (IL-2) as a maintenance treatment. On June 2002 the patient relapsed. A second complete remission was achieved by two cures of high dose aracytine and idarubicin. On October 2002 he received an allogeneic genoidentical hematopoietic stem-cell transplant (HSCT) following reduced intensity conditioning regimen consisting of fludarabine and 2 Gy of total body irradiation. Immunosuppressive prophylaxis treatment consisted of cyclosporine 6.25 mg/kg twice daily p.o. from day-3 and mycophenolate mofetil 15 mg/kg twice daily p.o. from day 0 until day þ27. The patient did not present any graft-versus-host disease (GVHD) and cyclosporine was interrupted on April 2003. On February 2004 he presented a recurrence of the papillary carcinoma and underwent transurethral resection. On April 2004 the patient received six intravesical instillations of ametycine for the prevention of recurrence of the TCC. On February 2006 he
Synthesis of AGVS by coloured-timed Petri nets

The paper presents a new AGVS modelling method using a class of command-place coloured-timed Petri nets (CPCTPN) . The CP-CTPN is capable of modelling many distinctive AGVS features, such as the functions of zone control and vehicle blocking, that are not generally available in most general-purpose commercial programmes. In the proposed new modelling method, the CP-CTPN is generated systematically in four steps by simply giving a floor-path layout and a management policy. These four modelling steps are; (1) to construct a PN-based floor-path model by assembling modular PN sub-models, (2) to incorporate coloured tokens and timed transitions into a CTPN, (3) to generate vehicle movement sequences by introducing relay functions and management commands into CP-CTPN, and (4) to compute reachable markings evolved from initial marking by incorporating the product of a coloured incident matrix and a firing sequence. Two floor-path examples, given by Hsieh and Sirinivasan, are presented to show the effectiveness o.
b-Carotene Produces Sustained Remissions in Patients With Oral Leukoplakia

Results: Fifty-four subjects were enrolled in the trial, with 50 being evaluable. At 6 months, 26 subjects (52%) had a clinical response. Twenty-three of the 26 responders completed the second, randomized phase. Only 2 (18%) of 11 in the b-carotene arm and 2 (17%) of 12 in the placebo arm relapsed. Baseline biopsies were performed in all patients, with dysplasia being present in 19 (38%) of the 50 evaluable patients. A second biopsy was obtained at 6 months in 23 subjects who consented to this procedure. There was improvement of at least 1 grade of dysplasia in 9 (39%), with no change in 14 (61%). Nutritional intake was assessed using food frequency questionnaires. There was no change in carotenoid intake during the trial. Responders had a lower intake of dietary fiber, fruits, folate, and vitamin E supplements than did nonresponders. b-Carotene levels were measured in plasma and oral cavity cells. Marked increases occurred during the 6-month induction. However, baseline levels were not restored in subjects taking placebo for 6 to 9 months after discontinuation of b-carotene therapy.
Optimizing QoS-based Service Selection in Service-oriented Architectures

In Service-oriented Architectures, services can be composed in a loosely coupled manner to realize business processes. Thereby, mentioned services are not necessarily located only within the borders of the own enterprise. In the Internet of Services, multiple service providers offer various services on several service marketplaces. In case services with comparable functionalities but varying quality levels are available at different costs, service requesters can decide, which services from which service providers to select. My research focuses on this service-selection-problem for complex workflows by formulating a linear optimization problem, which can be solved optimally using linear programming techniques. As the actual execution path is probably not known at planning time (e.g., for conditional braches), a worst-case, and an average-case analysis is performed. In addition to considering non-functional, quantitative service properties, I am working in my research towards integrating qualitative service features (as, e.g., security) for different, complex
Language to Specify Syntax-Guided Synthesis Problems

We present a language to specify syntax guided synthesis (SyGuS) problems. Syntax guidance is a prominent theme in contemporary program synthesis approaches, and SyGuS was first described in [1]. This paper describes concretely the input format of a SyGuS solver. [1] Rajeev Alur, Rastislav Bodik, Garvit Juniwal, Milo M. K. Martin, Mukund Raghothaman, Sanjit A. Seshia, Rishabh Singh, Armando Solar-Lezama, Emina Torlak, and Abhishek Udupa. Syntax-guided synthesis. In FMCAD, pages 1--17, 2013.
Differentiation of Embryonic Stem Cells Conditionally Expressing Neurogenin 3

Expression of the proendocrine gene neurogenin 3 (Ngn3) is required for the development of pancreatic islets. To better characterize the molecular events regulated by Ngn3 during development, we have determined the expression profiles of murine embryonic stem cells (mESCs) uniformly induced to overexpress Ngn3. An mESC line was created in order to induce Ngn3 by adding doxycycline to the culture medium. Genome‐wide microarray analysis was performed to identify genes regulated by Ngn3 in a variety of contexts, including undifferentiated ESCs and differentiating embryoid bodies (EBs). Genes regulated by Ngn3 in a context‐independent manner were identified and analyzed using systematic gene ontology tools. This analysis revealed Notch signaling as the most significantly regulated signaling pathway (p = .009). This result is consistent with the hypothesis that Ngn3 expression makes the cell competent for Notch signaling to be activated and, conversely, more sensitive to Notch signaling inhibition. Indeed, EBs induced to express Ngn3 were significantly more sensitive to γ‐secretase inhibitor‐mediated Notch signaling inhibition (p < .0001) when compared with uninduced EBs. Moreover, we find that Ngn3 induction in differentiating ESCs results in significant increases in insulin, glucagon, and somatostatin expression.
Fighting Against Hoax in Mitch Albom’s The First Phone Call From Heaven (2013): A Sociological Approach

This study discusses a hoax or a lie, namely the lie of a phone call from heaven in a novel by Mitch Albom entitled The First Phone Call From Heaven 2013 using the Sociological approach. The aim of this study is to identify hoaxes or telephone lies from heaven in a fictional city of Coldwater. The researcher used qualitative research to identify hoaxes in the story. Primary data and secondary data are 2 types of data in this study. The primary data from this research is Mitch Albom's The First Phone Call From Heaven and the Indonesian translation novel Phone First From Heaven by Julanda Tantani. And secondary data from this study was taken from literary books, 2 theses, accompanied by international journals, the internet and other data that could support this research. The steps to collect data are as follows: reading novels, searching for informative data on the internet, identifying, recording important things, compiling and forming conclusions and suggestions. The results of this study indicate that the story of a telephone lie from heaven can be solved by a figure who has a rational nature than from this story shows that there are faith, heaven, and god. And this lie from heaven explains if we believe in something miracle we don't need proof. The results of other studies related to sociology the author uses hoax that during this time the author created lies in this novel because while caring for his mother who was having a stroke and unable to talk later after his mother died he had a supposition if only the dead person could contact people who live, according to him, would be very happy, maybe it could be considered as a miracle.
A Family of Constrained Adaptive filtering Algorithms Based on Logarithmic Cost

This paper introduces a novel constraint adaptive filtering algorithm based on a relative logarithmic cost function which is termed as Constrained Least Mean Logarithmic Square (CLMLS). The proposed CLMLS algorithm elegantly adjusts the cost function based on the amount of error thereby achieves better performance compared to the conventional Constrained LMS (CLMS) algorithm. With no assumption on input, the mean square stability analysis of the proposed CLMLS algorithm is presented using the energy conservation approach. The analytical expressions for the transient and steady state MSD are derived and these analytical results are validated through extensive simulations. The proposed CLMLS algorithm is extended to the sparse case by incorporating the $\ell_1$-norm penalty into the CLMLS cost function. detailed Simulations confirms the superiority of the sparse CLMLS over the state-of-the-art.
SPITZER AS A MICROLENS PARALLAX SATELLITE: MASS MEASUREMENT FOR THE OGLE-2014-BLG-0124L PLANET AND ITS HOST STAR

We combine Spitzer and ground-based observations to measure the microlens parallax vector , and thus the mass and distance of OGLE-2014-BLG-0124L, making it the first microlensing planetary system with a space-based parallax measurement. The planet and star have masses of m ∼ 0.5 Mjup and M ∼ 0.7 M☉ and are separated by a⊥ ∼ 3.1 AU in projection. The main source of uncertainty in all of these numbers (approximately 30%, 30%, and 20%) is the relatively poor measurement of the Einstein radius θE, rather than uncertainty in πE, which is measured with 2.5% precision. This compares to 22% based on OGLE data alone, implying that the Spitzer data provide not only a substantial improvement in the precision of the πE measurement, but also the first independent test of a ground-based measurement.
Chick hair cells do not exhibit voltage‐dependent somatic motility

It is generally believed that mechanical amplification by cochlear hair cells is necessary to enhance the sensitivity and frequency selectivity of hearing. In the mammalian ear, the basis of cochlear amplification is believed to be the voltage‐dependent electromotility of outer hair cells (OHCs). The avian basilar papilla contains tall and short hair cells, with the former being comparable to inner hair cells, and the latter comparable to OHCs, based on their innervation patterns. In this study, we sought evidence for somatic electromotility by direct measurements of voltage‐dependent length changes in both tall and short hair cells at nanometre resolution. Microchamber and whole‐cell voltage‐clamp techniques were used. Motility was measured with a photodiode‐based measurement system. Non‐linear capacitance, an electrical signature of somatic motility, was also measured to complement motility measurement. Significantly, chick hair cells did not exhibit somatic motility nor express non‐linear capacitance. The lack of somatic motility suggests that in avian hair cells the active process resides elsewhere, most likely in the hair cell stereocilia.
Love wave devices with excellent temperature stability for application in gas sensor

The temperature property of Love wave device for application in gas sensor was analyzed theoretically by solving the coupled electromechanical field equation, and the optimal design parameters were extraction, leading to excellent temperature stability. Low temperature coefficient of the fabricated Love wave delay lines with guide layer of SU-8 on ST-90°X quartz substrate is achieved experimentally as only -4.4 ppm/°C, which agrees well with the calculated results.
Sexual dichromatism in wing pigmentation of New World dragonflies follows Rensch's rule

Many animal taxa that display sexual size dimorphism (SSD) exhibit a positive allometric relationship in which the degree of dimorphism increases with body size. This macroevolutionary pattern is known as Rensch's rule. Although sexual selection is hypothesized to be the main mechanism causing this pattern, body size is influenced by several selective forces, including natural and sexual selection. Therefore, by focusing exclusively on SSD one cannot ascertain which of these selective forces drives Rensch's rule. If sexual selection is indeed the main mechanism underlying Rensch's rule, we predict that other sexually selected traits, including coloration‐based ornaments, will also exhibit interspecific allometric scaling consistent with Rensch's rule. We tested this prediction using wing pigmentation of 89 species of dragonflies. Studies show that male wing pigmentation is generally under strong intra‐ and intersexual selection, so that sexual dichromatism in this trait should follow Rensch's rule. Conversely, the available evidence suggests that male body size is usually not sexually selected in dragonflies, so we do not expect SSD to follow Rensch's rule. First, we found that sexual dichromatism in wing pigmentation was consistent with Rensch's rule. The phylogenetic major axis regression slope was significantly greater than one. We also showed that the allometric slope for SSD was not different from unity, providing no support for Rensch's rule. Our results provide the first evidence that a trait which appears to be under strong sexual selection exhibits a pattern consistent with Rensch's rule.
STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies

Incomplete reporting has been identified as a major source of avoidable waste in biomedical research. Essential information is often not provided in study reports, impeding the identification, critical appraisal, and replication of studies. To improve the quality of reporting of diagnostic accuracy studies, the Standards for Reporting Diagnostic Accuracy (STARD) statement was developed. Here we present STARD 2015, an updated list of 30 essential items that should be included in every report of a diagnostic accuracy study. This update incorporates recent evidence about sources of bias and variability in diagnostic accuracy and is intended to facilitate the use of STARD. As such, STARD 2015 may help to improve completeness and transparency in reporting of diagnostic accuracy studies.
Distributed Differential Evolution Based on Adaptive Mergence and Split for Large-Scale Optimization

Nowadays, large-scale optimization problems are ubiquitous in many research fields. To deal with such problems efficiently, this paper proposes a distributed differential evolution with adaptive mergence and split (DDE-AMS) on subpopulations. The novel mergence and split operators are designed to make full use of limited population resource, which is important for large-scale optimization. They are adaptively performed based on the performance of the subpopulations. During the evolution, once a subpopulation finds a promising region, the current worst performing subpopulation will merge into it. If the merged subpopulation could not continuously provide competitive solutions, it will be split in half. In this way, the number of subpopulations is adaptively adjusted and better performing subpopulations obtain more individuals. Thus, population resource can be adaptively arranged for subpopulations during the evolution. Moreover, the proposed algorithm is implemented with a parallel master–slave manner. Extensive experiments are conducted on 20 widely used large-scale benchmark functions. Experimental results demonstrate that the proposed DDE-AMS could achieve competitive or even better performance compared with several state-of-the-art algorithms. The effects of DDE-AMS components, adaptive behavior, scalability, and parameter sensitivity are also studied. Finally, we investigate the speedup ratios of DDE-AMS with different computation resources.
Non-Oberbeck-Boussinesq natural convection in a tall differentially heated cavity

Abstract. Turbulent flow in a water-filled rectangular parallelepiped tank of an integrated solar collector is analyzed by means of a set of two and three dimensional simulations. The geometry and the working conditions of the prototype yield an aspect ratio of Γ = 6.68, Rayleigh number of Ra = 2.2 × 10 and a Prandtl number of Pr = 3.42. Different coarse DNS simulations and LES simulations using the dynamic Smagorinsky SGS and WALE model are presented. Validity of the Oberbeck-Boussinesq approximation is questioned. Heat transfer and first and second order statistics are studied.
The Reliability and Validity of a Modified Total Neuropathy Score-Reduced and Neuropathic Pain Severity Items When Used to Measure Chemotherapy-Induced Peripheral Neuropathy in Patients Receiving Taxanes and Platinums

Background: Assessment of chemotherapy-induced peripheral neuropathy signs and symptoms has been hampered because of the lack of simple, reliable, and valid measures. Objective: The study objective was to examine the internal consistency and interrater reliability as well as the structural validity of a 5-component total neuropathy score-reduced (TNSr) variant and a chemotherapy-induced neuropathy-specific Neuropathic Pain Scale. Methods: One hundred seventeen outpatients receiving taxanes or platinums were assessed by a consistent nurse practitioner using the 2 instruments. Ten subjects participated in interrater reliability testing. Results: Mean scores and SDs for individual items were low. The strength item was deleted because of low interitem correlations and a floor effect. The reflex item was deleted because of low interitem correlations and its negative influence on Cronbach &agr;. Pin sensibility was deleted because of low factor loadings. The TNSr-short form and the chemotherapy-induced neuropathy-specific Neuropathic Pain Scale formed 2 distinct factors, providing evidence of structural validity. Cronbach &agr;'s for the 2 instruments were . 80 and . 96, respectively. The TNSr interrater reliability results suggested acceptable rater concordance, but minor revisions could further improve scoring precision. Conclusion: Clinimetric evidence supports the use of 2 new instruments when monitoring taxane- and platinum-related neuropathy and pain. Further instrument modifications are recommended, followed by additional testing in diverse populations. Implications for Practice: With these new instruments, nurses can more easily incorporate prospective neuropathy assessment into daily clinical practice. The outcome will be improved symptom awareness by oncology clinicians and patients, leading to fewer chemotherapy-induced peripheral neuropathy-related devastating effects on functionality and quality of life.
1-Nitro-4-(4-nitrophenoxy)benzene: a second monoclinic polymorph

In the title compound, C12H8N2O5, the aromatic rings are inclined to one another by 56.14 (7)°. The nitro groups are inclined by to the benzene rings to which they are attached by 3.86 (17) and 9.65 (15)°. In the crystal, molecules are linked by C—H⋯O hydrogen bonds, forming a three-dimensional structure. The title compound is a new monoclinic polymorph, crystallizing in space group P21/c. The first polymorph crystallized in space group C2/c and the molecule possesses twofold rotation symmetry. Two low-temperature structures of this polymorph (150 K and 100 K, respectively) have been reported [Meciarova et al. (2004). Private Communication (refcode IXOGAD). CCDC, Cambridge, England, and Dey & Desiraju (2005). Chem. Commun. pp. 2486–2488].