Miracle-dz/UniFAR-FTUs huggingface dataset:
A randomized trial of sertraline, self-administered cognitive behavior therapy, and their combination for panic disorder

Background Self-administered cognitive behavior therapy (SCBT) has been shown to be an effective alternative to therapist-delivered treatment for panic disorder (PD). However, it is unknown whether combining SCBT and antidepressants can improve treatment. This trial evaluated the efficacy of SCBT and sertraline, alone or in combination, in PD. Method Patients (n=251) were randomized to 12 weeks of either placebo drug, placebo drug plus SCBT, sertraline, or sertraline plus SCBT. Those who improved after 12 weeks of acute treatment received treatment for an additional 12 weeks. Outcome measures included core PD symptoms (panic attacks, anticipatory anxiety, agoraphobic avoidance), dysfunctional cognitions (fear of bodily sensations, agoraphobic cognitions), disability, and clinical global impression of severity and improvement. Efficacy data were analyzed using general and generalized linear mixed models. Results Primary analyses of trends over time revealed that sertraline/SCBT produced a significantly greater rate of decline in fear of bodily sensations compared to sertraline, placebo/SCBT and placebo. Trends in other outcomes were not significantly different over time. Secondary analyses of mean scores at week 12 revealed that sertraline/SCBT fared better on several outcomes than placebo, with improvement being maintained at the end of continuation treatment. Outcome did not differ between placebo and either sertraline monotherapy or placebo/SCBT. Moreover, few differences emerged between the active interventions. Conclusions This trial suggests that sertraline combined with SCBT may be an effective treatment for PD. The study could not confirm the efficacy of sertraline monotherapy or SCBT without concomitant medication or therapist assistance in the treatment of PD.
Optimally smooth norm-conserving pseudopotentials.

Modern norm-conserving pseudopotentials are constructed to satisfy a set of criteria for the matching of pseudo- and all-electron eigenvalues and wave functions. In practice, it is also desirable that they be as smooth as possible, so that their reciprocal-space representation decays as quickly as possible. To this end, a simple modification of a standard pseudopotential generation scheme is developed. The new, smoother potentials are shown to decay significantly faster in reciprocal space, with no loss of transferability.
Fast pulse analysis of TiO2 based RRAM nano-crossbar devices

Switchable metal-insulator-metal (MIM) structures are the key elements for future non-volatile resistive RAM (RRAM) devices. Recently this type of memory device has attracted considerable interest due to the prospect of non-volatile data storage combined with low power consumption, excellent scalability and very fast write/read operation. However the physical processes responsible for the fast resistive switching are still under investigation. In this work we will present the replacement of the time consuming quasi-static current driven electroforming process by short voltage pulse induced electroforming. Furthermore resistive switching was measured with voltage pulses down to 5 ns pulse width with an in-situ recording of the current response. The high-frequency measurements provide a deeper insight into the physical background of fast data operation.
Effective capacity limits of cognitive radio networks under peak interference constraint

In cognitive radio networks, a cognitive user (CU) can share the same frequency band with the primary user (PU) as long as the interference introduced to the PU is below a given interference limit. In this paper, we study the performance limits of CU's effective capacity by taking the instantaneous quality of services (QoS) of the PU into consideration. Considering the case with either single or multiple primary receivers, we derive closed-form expressions for the effective capacity for both of the above scenarios. We further analyze the performance limits of the asymptotic capacity when the received signal bandwidth approaches infinity, and obtain the closed-form expressions by taking both single and multiple primary receivers into consideration. Numerical results are provided to confirm the effectiveness of our theoretical analysis.
Mitochondrial disease in Southwestern Finland. Population-based molecular genetic and clinical studies

Mika H. Martikainen Mitochondrial disease in southwestern Finland. Population-based molecular genetic and clinical studies From the the Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland Annales Universitatis Turkuensis Ser. D Painosalama Oy, Turku, Finland 2012 Mitochondria are present in all eukaryotic cells. They enable these cells utilize oxygen in the production of adenosine triphosphate in the oxidative phosphorylation system, the mitochondrial respiratory chain. The concept ‘mitochondrial disease’ conventionally refers to disorders of the respiratory chain that lead to oxidative phosphorylation defect. Mitochondrial disease in humans can present at any age, and practically in any organ system. Mitochondrial disease can be inherited in maternal, autosomal dominant, autosomal recessive, or X-chromosomal fashion. One of the most common molecular etiologies of mitochondrial disease in population is the m.3243A>G mutation in the MT-TL1 gene, encoding mitochondrial tRNALeu(UUR). Clinical evaluation of patients with m.3243A>G has revealed various typical clinical features, such as stroke-like episodes, diabetes mellitus and sensorineural hearing loss. The prevalence and clinical characteristics of mitochondrial disease in population are not well known. This thesis consists of a series of studies, in which the prevalence and characteristics of mitochondrial disease in the adult population of Southwestern Finland were assessed. Mitochondrial haplogroup Uk was associated with increased risk of occipital ischemic stroke among young women. Large-scale mitochondrial DNA deletions and mutations of the POLG1 gene were the most common molecular etiologies of progressive external ophthalmoplegia. Around 1% of diabetes mellitus emerging between the ages 18 – 45 years was associated with the m.3243A>G mutation. Moreover, among these young diabetic patients, mitochondrial haplogroup U was associated with maternal family history of diabetes. These studies demonstrate the usefulness of carefully planned molecular epidemiological investigations in the study of mitochondrial disorders.
TCR-Independent CD30 Signaling Selectively Induces IL-13 Production Via a TNF Receptor-Associated Factor/p38 Mitogen-Activated Protein Kinase-Dependent Mechanism1

Initiation of T lymphocyte responses to most Ags requires concurrent stimulation through the TCR and costimulatory receptors such as CD28. Following initial activation, secondary receptors are up-regulated that can costimulate T cells in concert with TCR engagement. One such receptor is the TNFR family member CD30. In this study, we report that unlike CD28, ligation of CD30 on normal effector T cells induces IL-13 production in the absence of concurrent TCR engagement. TCR-independent CD30-mediated IL-13 release correlated with activation of c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), and NF-κB, and was completely inhibited by the expression of a TNFR-associated factor 2 (TRAF2) dominant-negative transgene (TRAF2.DN-Tg), but not by that of an I-κBα dominant-negative transgene. In parallel, expression of the TRAF2.DN-Tg selectively prevented the induction of c-Jun N-terminal kinase and p38 MAPK, but not that of NF-κB. Furthermore, IL-13 production was reduced in a dose-dependent manner by the p38 MAPK inhibitor SB203580. Together, these results suggest that TCR-independent CD30-mediated production of IL-13 is triggered by association of CD30 with TRAF family members and subsequent activation of p38 MAPK. Inasmuch as IL-13 can promote airway inflammation and cancer progression, production of IL-13 in a TCR-independent manner has important pathological implications in vivo.
Detonation Diffraction in Regular and Irregular Mixtures

Diffraction of a gaseous detonation has been widely studied [1–7] in the context of both applications and as a scientific experiment that provides insight into the interaction between the combustion processes at the wavefront and the fluid motion induced by the diffraction process. For detonation propagation in tubes and channels, it is firmly established that there are reasonably well-defined critical conditions (e.g., diameter dc) that separate failure (sub-critical) and successful detonation transition (super-critical) when diffracting into a larger volume. However, there is no fundamental theory for the prediction of the critical quantities like dc. The empirical correlation dc ≈ 13λ holds for many common fuel-oxygen or -air mixtures [8] but breaks down for mixtures with a large amount of argon dilution. Critical tube diameters of up to 30 λ were measured [3] for stoichiometric C2H2-O2 mixtures with 80% Ar dilution. This effect appears to be linked to systematic differences in the regularity of the instability pattern on the detonation front with variations in the mixture composition [9] in fully developed detonations. Recently, we [10, 11] have proposed that the effective normalized activation energies θ (θ = Ea/RTps) can be used as a figure of merit to characterize the degree of cellular regularity in propagating detonation. Lee [12] has proposed that the mechanisms of detonation failure are qualitatively different in mixtures with regular and irregular cellular structure and that this is linked to the different roles of transverse waves in the combustion process. The objective of the present study is to obtain detailed measurements that can be used to provide quantitative data to test the various theories about detonation diffraction and speculations about the role of transverse waves in mixtures with very different degrees of cellular regularity. To do this, we use laser schlieren photography, multiple-exposure chemiluminescence imaging and, for the first time in a diffraction experiment, planar laser-induced fluorescence (PLIF) of the OH radical, Fig. 1. The reaction front velocity was obtained from the multiple exposure chemiluminescence images. The mixtures studied were H2-N2O (θ = 9.5) which has an irregular cellular structure, and up to 70% Ar-diluted H2-O2 (θ = 4.5), which has a very regular cellular structure. Instead of characterizing the mixtures by cell width, a poorly defined quantity in irregular mixtures, we have used the calculated induction zone length ∆ at Chapman Jouguet (CJ) conditions. In terms of this, the critical diameters are dc ≈ 530∆ for θ = 4.5 and dc ≈ 230∆ for θ = 9.5. The detonation diffraction facility consists of a 1.5 m long tube with a circular cross section and an inner diameter d of 38 mm joined through a sharp 90◦corner to a 0.8 m long, 150 mm square test section. The tube is equipped at the ignition end with a 305 mm long Shchelkin spiral and spark plug. Pressure histories were
Psychometric characteristics of the Beck Depression Inventory-II with college students of diverse ethnicity

Introduction To evaluate the psychometric characteristics of the Beck Depression Inventory – Second Edition (BDI-II) with an ethnically diverse sample of college students. Methods The BDI-II was completed by a group of 502 college students (54% women) with an ethnic distribution of African-American (n=49, 10%), Asian-American (n=33, 7%), Hispanic (n=113, 22%), Native-American (n=10, 2%), and White (n=297, 59%). Psychometric characteristics of the inventory with the ethnically diverse group were compared to the results published in the test manual for nonclinical samples composed predominantly of European and White participants. Results Using confirmatory factor analyses, a three-factor model that identified negative attitude, performance difficulty, and somatic dimensions, provides a better fit of the data than does the two-factor model. Similar psychometric characteristics were found between the ethnically diverse student sample and the standardization sample. Based on multivariate analysis of variance, White students had higher scores on the item of agitation compared to Asian-American students and on the items of worthlessness and irritability compared to Hispanic students. Conclusion The results of the psychometric analyses suggest that the BDI-II is suitable as a screening instrument for depression in college populations of diverse ethnicity.
A pilot study to explore the role of a low-carbohydrate intervention to improve GGT levels and HbA 1 c

See page 108 for author information. Excess dietary glucose is believed to lead to insulin resistance, type 2 diabetes and also progressive hepatocyte triglyceride accumulation (non-alcoholic fatty liver disease [NAFLD]). Considering the increased cardiovascular risks associated with NAFLD and type 2 diabetes, effective risk factor management of individuals with these conditions is critical. Weight loss can improve abnormal liver biochemistry, the histological progression of NAFLD and diabetes control. However, the most effective diet remains controversial. The authors implemented a low-carbohydrate (CHO) diet in a primary healthcare setting and assessed its effect on weight, HbA1c, serum gamma-glutamyl transferase (GGT) and cholesterol. In this article, the authors present their findings and question the role of dietary CHO in the aetiology of abnormal liver biochemistry and diabetes.
Relationship between action spectra for chlorophyll a fluorescence and photosynthetic O2 evolution in algae

Relative excitation spectra of chlorophyll a fluorescence are shown to be very close to relative action spectra of photosystem II O2 evolution in seven micro- and macro-algae of five phyla. The conditions under which this correspondence should hold, based on theoretical considerations, and the applications of this correspondence to interpretation of fluorescence excitation spectra of chlorophyll a from natural popula- tions are discussed. The spectra presented are interpreted in relation to the light-harvesting pigments and their association with the two photosystems.
Output feedback tracking of nonholonomic systems in chained form

In this paper we study the tracking problem for the class of non-holonomic systems in chained form. In particular, with as outputs the first and last state component of the chained form, we suggest a solution for the output tracking problem by combining a time-varying state feedback controller with an observer for the chained form system. For the stability analysis of the “certainty equivalence type” of controller we use a cascaded systems approach. The resulting closed loop system is globally K-exponentially stable.
What's the Difference between Men and Women? Evidence from Facial Measurement

Human subjects are able to identify the sex of faces with very high accuracy. Using photographs of adults in which hair was concealed by a swimming cap, subjects performed with 96% accuracy. Previous work has identified a number of dimensions on which the faces of men and women differ. An attempt to combine these dimensions into a single function to classify male and female faces reliably is described. Photographs were taken of 91 male and 88 female faces in full face and profile. These were measured in several ways: (i) simple distances between key points in the pictures; (ii) ratios and angles formed between key points in the pictures; (iii) three-dimensional (3-D) distances derived by combination of full-face and profile photographs. Discriminant function analysis showed that the best discriminators were derived from simple distance measurements in the full face (85% accuracy with 12 variables) and 3-D distances (85% accuracy with 6 variables). Combining measures taken from the picture plane with those derived in 3-D produced a discriminator approaching human performance (94% accuracy with 16 variables). Performance of the discriminant function was compared with that of human perceivers and found to be correlated, but far from perfectly. The difficulty of deriving a reliable function to distinguish between the sexes is discussed with reference to the development of automatic face-processing programs in machine vision. It is argued that such systems will need to incorporate an understanding of the stimuli if they are to be effective.
Time to Diagnosis: Accounting for Differential Endpoint Follow-up in Multi-Cohort Studies

Cox regression is widely used to analyze discrete survival time data. Differential endpoint follow-up across sub-cohorts where distribution of a covariate varies may cause typical estimators to be biased or inefficient. We demonstrate that with Cardiovascular Health Study data for incident type 2 diabetes. Two cohorts with extremely different race distribution have differential follow-up for fasting glucose levels. We study various scenarios of Cox regression. We suggest an alternative approach, Poisson generalized estimating equations with an offset to accommodate the differential follow-up. We use simulations to contrast the methods.
Coverage and Representation of Condoms in Conjunction with HIV/AIDS in the Kenyan Daily Nation Newspaper from 1989–2003: A Qualitative Content Analysis to Inform Health Promotion

HIV/AIDS has been a pressing problem in the East African country of Kenya for over 20 years. Promotion of condom use is one prevention strategy embraced in global health prevention of HIV, but use remains relatively low in Kenya. In order to better understand the socio-historic context of discourses about condoms in Kenya, this study explored how condoms were covered and represented in the Kenyan Daily Nation newspaper from 1989–2003. Qualitative content analysis was conducted for 91 items from the Daily Nation including articles, letters to the editor, columns, opinion and editorial pieces, advertisements, and cartoons. These items were systematically examined for the manner and content of manifest and latent references to condoms. Researchers found four major themes, “controversy and confusion,” “we need to do more: condoms might help,” “not for Kenyans or from Kenyans,” and “stigmatized associations. ” Findings provide needed insight into the socio-cultural context surrounding condoms in Kenya that is often lacking within health promotion and HIV prevention programs.
Impaired stretch modulation in potentially lethal cardiac sodium channel mutants

R1623Q and R1626P, slowly inactivating mutants of sodium channel, Nav1.5, associate with sporadic Long-QT3 (LQT3), a syndrome involving ventricular tachyarrhythmias and lethal cardio/respiratory disturbances. Cardiac mechanoelectric feedback is considered a factor in sporadic arrhythmias, and since stretch and shear forces modulate hNav1.5 gating, gating mechanics of LQT-Nav1.5 channels might provide insights. We compared recombinant R1623Q and WT currents in quiescent and stretched membrane of cell-attached patches of Xenopus oocytes. Macroscopic current was monitored before, during and after stretch induced by pipette suction. In either channel peak current at small depolarizations could be more than doubled by stretch. As in WT, R1623Q showed reversible stretch intensity dependent stretch-acceleration of current onset and decay at all voltages, with kinetic coupling between the two processes retained during stretch. The channels differed in the absolute extent of kinetic acceleration for a given stretch intensity; over a range of intensities, R1623Q inactivation speed increased significantly less than did WT. The LQT3 mutant R1626P also retained its kinetic coupling during stretch. Whereas stretch-difference currents in WT were mostly inhibitory, they were substantially (R1623Q) or entirely (R1626P) excitatory for the LQT3 mutants. If stretch-modulated Nav1.5 current (i.e. brief excitation followed by accelerated current decay) routinely contributes to cardiac mechanoelectric feedback, then during hemodynamic load variations, the abnormal stretch-modulated components of R1623Q and R1626P current could be perilously pro-arrhythmic.
Radical Modernism and the Failure of Style: Philosophical Reflections on Maeterlinck-Debussy's Pellééas et Méélisande

Plot-summary: Golaud, grandson of King Arkel of destitute Allemonde, has lost his way hunting in a forest. He sees Melisande crying beside a pool of water. Afraid and avoiding questions, she tells him she comes from a place to which she does not wish to return. He oVers to retrieve her crown, which he sees lying in the water; she forbids him. Married, they return to his family castle. Melisande meets Golaud’s half-brother, Pelleas, who is about to visit a dying friend but is delayed because his father is ill. Pelleas and Melisande meet at the Fountain of the Blind. At midday she lets her wedding ring drop into the water. At the same time Golaud falls from his horse. Injured, he returns to the castle. He is upset by the loss of Melisande’s ring. Ignoring Pelleas’s advice to tell the truth, she says she lost it in the sea vaults. Golaud sends her and Pelleas to look for it. Later, Melisande sits by a window in the castle tower. Pelleas arrives and entangles himself in her hair, which cascades down the wall. Golaud arrives and warns them against these ‘‘childish games. ’’ He warns Pelleas to stay away from Melisande and suggests she might be with child. He uses Yniold, his son from his rst marriage, to spy on the lovers, but Yniold does not answer his questions the way Golaud wants him to. He says Pelleas and Melisande are standing silently, staring into the light. Pelleas’s father recovers his health, which allows Pelleas now to leave. Arkel tells Melisande he hopes she will bring happiness to the castle. Golaud enters the room and shows his fury toward Melisande. Pelleas and Melisande meet to say farewell. They openly declare their love. Golaud arrives, kills Pelleas, and wounds Melisande. She dies shortly thereafter (not from the wound) and after having given birth. Calm, forgiving, but still stubborn, she does not appease Golaud’s jealous torment.
Subcellular Location of the Major Protein Antigens of Paramyxoviruses Revealed by Immunoperoxidase Cytochemistry

The major structural proteins of Newcastle disease virus and Sendai virus were localized in infected BHK‐21 and MDBK cells by ultrastructural immunoperoxidase cytochemistry using antibodies against the individual viral protein antigens. The intracellular glycoproteins were strictly membrane bound, being localized in the rough endoplasmic reticulum (RER), perinuclear spaces, smooth membrane vesicles, and presumed Golgi apparatus. The nucleocapsid proteins were detected exclusively in membrane free cytosol and accumulated there, forming inclusions. The membrane (M) protein was found both in cytosol and on RER. The viral proteins on RER exhibited a distinct site specificity; the glycoproteins were facing the lumen of RER whereas M protein was present at the outer cytoplasmic surface. All the viral proteins were detectable at the plasma membrane where virus assembly takes place. However, their modes of distribution differed remarkably. The glycoproteins were spread widely over the entire cell surface including the areas of virus budding and those of normal morphology, whereas M protein was localized in restricted areas of the membrane, frequently forming a patch of virus specific membrane. The presence of nucleocapsids was confined to the virus particles budding from the plasma membrane. These results complement and extend the earlier morphological and biochemical data on the assembly or morphogenesis of paramyxoviruses.