Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicting relevance of change recommendations

Software change recommendation seeks to suggest artifacts (e.g., files or methods) that are related to changes made by a developer, and thus identifies possible omissions or next steps. While one obvious challenge for recommender systems is to produce accurate recommendations, a complimentary challenge is to rank recommendations based on their relevance. In this paper, we address this challenge for recommendation systems that are based on evolutionary coupling. Such systems use targeted association-rule mining to identify relevant patterns in a software system's change history. Traditionally, this process involves ranking artifacts using interestingness measures such as confidence and support. However, these measures often fall short when used to assess recommendation relevance. We propose the use of random forest classification models to assess recommendation relevance. This approach improves on past use of various interestingness measures by learning from previous change recommendations. We empirically evaluate our approach on fourteen open source systems and two systems from our industry partners. Furthermore, we consider complimenting two mining algorithms: Co-Change and Tarmaq. The results find that random forest classification significantly outperforms previous approaches, receives lower Brier scores, and has superior trade-off between precision and recall. The results are consistent across software system and mining algorithm.
Evaluation of Presence in Virtual Environments: Haptic Vest and User’s Haptic Skills

This paper presents the integration of a haptic vest with a multimodal virtual environment, consisting of video, audio, and haptic feedback, with the main objective of determining how users, who interact with the virtual environment, benefit from tactile and thermal stimuli provided by the haptic vest. Some experiments are performed using a game application of a train station after an explosion. The participants of this experiment have to move inside the environment, while receiving several stimuli to check if any improvement in presence or realism in that environment is reflected on the vest. This is done by comparing the experimental results with those similar scenarios, obtained without haptic feedback. These experiments are carried out by three groups of participants who are classified on the basis of their experience in haptics and virtual reality devices. Some differences among the groups have been found, which can be related to the levels of realism and synchronization of all the elements in the multimodal environment that fulfill the expectations and maximum satisfaction level. According to the participants in the experiment, two different levels of requirements are to be defined by the system to comply with the expectations of professional and conventional users.
Aprepitant as a fourth antiemetic prophylactic strategy in high‐risk patients: a double‐blind, randomized trial

Post‐operative nausea and vomiting (PONV) is one of the most important causes of patient discomfort after laparoscopic surgeries despite the use of a multimodal pharmacological approach. This study assessed whether the addition of aprepitant to a multimodal regimen would further decrease the incidence of PONV in high‐risk patients.
Hand-Sewn versus Stapled Closure of Loop Ileostomy: A Meta-Analysis

Background: Individual trials comparing hand-sewn with stapled closure of loop ileostomy show different outcomes due to lack of statistical power. A systematic review, with a pooled analysis of results, might provide a more definitive answer. This review aimed to compare hand-sewn with stapled anastomotic technique for closure of a loop ileostomy and looked at the effect of bowel resection on the complication rates. Methodology: Relevant studies were identified from MEDLINE, EMBASE and the Cochrane database. All randomised clinical trials, prospective and retrospective studies comparing hand-sewn with stapled closure of loop ileostomy were included. Results: Of the 4,917 patients in 15 identified studies, 3,406 had hand-sewn and 1,511 stapled anastomosis. There was no difference in the rate of anastomotic leak between the hand-sewn (2.93%, 55/1,877) and the stapled group (2.08%, 25/1,202) (OR 0.81, 95% CI 0.43–1.54, p = 0.52, I2 = 33%). The rate of small-bowel obstruction was higher in the hand-sewn group (7.03%, 231/3,284) compared to the stapled group (5.58%, 73/1,308; OR 0.69, 95% CI 0.51–0.92, p = 0.01, I2 = 0%). There was no difference in the incidence of anastomotic leak and small-bowel obstruction in the hand-sewn anastomosis between patients with or without bowel resection. Conclusions: There was no significant difference in the rate of anastomotic leakage between the hand-sewn and stapled techniques. The rate of small-bowel obstruction was higher in the hand-sewn group. Performance of bowel resection does not significantly increase the incidence of anastomotic leak or small-bowel obstruction.
Estrogen Receptor Binding Affinity of Food Contact Material Components Estimated by QSAR.

AIM The presented work characterized components of food contact materials (FCM) with potential to bind to estrogen receptor (ER) and cause adverse effects in the human organism. METHODS The QSAR Toolbox, software application designed to identify and fill toxicological data gaps for chemical hazard assessment, was used. Estrogen receptors are much less of a lock-and-key interaction than highly specific ones. The ER is nonspecific enough to permit binding with a diverse array of chemical structures. There are three primary ER binding subpockets, each with different requirements for hydrogen bonding. RESULTS More than 900 compounds approved as of FCM components were evaluated for their potential to bind on ER. All evaluated chemicals were subcategorized to five groups with respect to the binding potential to ER: very strong, strong, moderate, weak binder, and no binder to ER. In total 46 compounds were characterized as potential disturbers of estrogen receptor. CONCLUSION Among the group of selected chemicals, compounds with high and even very high affinity to the ER binding subpockets were found. These compounds may act as gene activators and cause adverse effects in the organism, particularly during pregnancy and breast-feeding. It should be considered to carry out further in vitro or in vivo tests to confirm their potential to disturb the regulation of physiological processes in humans by abnormal ER signaling and subsequently remove these chemicals from the list of approved food contact materials.
Matching shielded loops for cryptographic analysis

Many sensors used for side channel analysis are simple coils, obtained without much design effort. The sensor is however a signiÞcant element in the measurement chain and should therefore be carefully designed. In this paper matching of some possible sensor topologies is investigated. Matching is needed to avoid resections that would spoil the signal. This matching is however slightly different from what matching stands for in every day antenna practice. For our purpose it is best to match the sensor, but use a scope that is deliberately mismatched to the cable. Of the loops investigated, none had acceptable matching over the entire frequency range of interest. A combination of two loop types was suggested as a possible solution.
Multiview Facial Landmark Localization in RGB-D Images via Hierarchical Regression With Binary Patterns

In this paper, we propose a real-time system of multiview facial landmark localization in RGB-D images. The facial landmark localization problem is formulated into a regression framework, which estimates both the head pose and the landmark positions. In this framework, we propose a coarse-to-fine approach to handle the high-dimensional regression output. At first, 3-D face position and rotation are estimated from the depth observation via a random regression forest. Afterward, the 3-D pose is refined by fusing the estimation from the RGB observation. Finally, the landmarks are located from the RGB observation with gradient boosted decision trees in a pose conditional model. The benefits of the proposed localization framework are twofold: the pose estimation and landmark localization are solved with hierarchical regression, which is different from previous approaches where the pose and landmark locations are iteratively optimized, which relies heavily on the initial pose estimation; due to the different characters of the RGB and depth cues, they are used for landmark localization at different stages and incorporated in a robust manner. In the experiments, we show that the proposed approach outperforms state-of-the-art algorithms on facial landmark localization with RGB-D input.
Slant rectification in Russian passport OCR system using fast Hough transform

In this paper, we introduce slant detection method based on Fast Hough Transform calculation and demonstrate its application in industrial system for Russian passports recognition. About 1.5% of this kind of documents appear to be slant or italic. This fact reduces recognition rate, because Optical Recognition Systems are normally designed to process normal fonts. Our method uses Fast Hough Transform to analyse vertical strokes of characters extracted with the help of x-derivative of a text line image. To improve the quality of detector we also introduce field grouping rules. The resulting algorithm allowed to reach high detection quality. Almost all errors of considered approach happen on passports of nonstandard fonts, while slant detector works in appropriate way.
When gestures show us the way: Co-thought gestures selectively facilitate navigation and spatial memory

ABSTRACT How does gesturing during route learning relate to subsequent spatial performance? We examined the relationship between gestures produced spontaneously while studying route directions and spatial representations of the navigated environment. Participants studied route directions, then navigated those routes from memory in a virtual environment, and finally had their memory of the environment assessed. We found that, for navigators with low spatial perspective-taking performance on the Spatial Orientation Test, more gesturing from a survey perspective predicted more accurate memory following navigation. Thus, co-thought gestures accompanying route learning relate to performance selectively, depending on the gesturers’ spatial ability and the perspective of their gestures. Survey gestures may help some individuals visualize an overall route that they can retain in memory.
Development of a thermosensitive HAMA-containing bio-ink for the fabrication of composite cartilage repair constructs

Fine-tuning of bio-ink composition and material processing parameters is crucial for the development of biomechanically relevant cartilage constructs. This study aims to design and develop cartilage constructs with tunable internal architectures and relevant mechanical properties. More specifically, the potential of methacrylated hyaluronic acid (HAMA) added to thermosensitive hydrogels composed of methacrylated poly[N-(2-hydroxypropyl)methacrylamide mono/dilactate] (pHPMA-lac)/polyethylene glycol (PEG) triblock copolymers, to optimize cartilage-like tissue formation by embedded chondrocytes, and enhance printability was explored. Additionally, co-printing with polycaprolactone (PCL) was performed for mechanical reinforcement. Chondrocyte-laden hydrogels composed of pHPMA-lac-PEG and different concentrations of HAMA (0%–1% w/w) were cultured for 28 d in vitro and subsequently evaluated for the presence of cartilage-like matrix. Young’s moduli were determined for hydrogels with the different HAMA concentrations. Additionally, hydrogel/PCL constructs with different internal architectures were co-printed and analyzed for their mechanical properties. The results of this study demonstrated a dose-dependent effect of HAMA concentration on cartilage matrix synthesis by chondrocytes. Glycosaminoglycan (GAG) and collagen type II content increased with intermediate HAMA concentrations (0.25%–0.5%) compared to HAMA-free controls, while a relatively high HAMA concentration (1%) resulted in increased fibrocartilage formation. Young’s moduli of generated hydrogel constructs ranged from 14 to 31 kPa and increased with increasing HAMA concentration. The pHPMA-lac-PEG hydrogels with 0.5% HAMA were found to be optimal for cartilage-like tissue formation. Therefore, this hydrogel system was co-printed with PCL to generate porous or solid constructs with different mesh sizes. Young’s moduli of these composite constructs were in the range of native cartilage (3.5–4.6 MPa). Interestingly, the co-printing procedure influenced the mechanical properties of the final constructs. These findings are relevant for future bio-ink development, as they demonstrate the importance of selecting proper HAMA concentrations, as well as appropriate print settings and construct designs for optimal cartilage matrix deposition and final mechanical properties of constructs, respectively.
Public-Key Cryptography for RFID-Tags

RFID-tags are a new generation of bar-codes with added functionality. An emerging application is the use of RFID-tags for anti-counterfeiting by embedding them into a product. Public-key cryptography (PKC) offers an attractive solution to the counterfeiting problem but whether a publickey cryptosystem can be implemented on an RFID tag or not remains unclear. In this paper, we investigate which PKC-based identification protocols are useful for these anti-counterfeiting applications. We also discuss the feasibility of identification protocols based on elliptic curve cryptography (ECC) and show that it is feasible on RFID tags. Finally, we compare different implementation options and explore the cost that side-channel attack countermeasures would have on such implementations
Insight into higher-level phylogeny of Neuropterida: Evidence from secondary structures of mitochondrial rRNA genes and mitogenomic data

It is well known that the rRNA structure information is important to assist phylogenetic analysis through identifying homologous positions to improve alignment accuracy. In addition, the secondary structure of some conserved motifs is highly stable among distantly related taxa, which can provide potentially informative characters for estimating phylogeny. In this paper, we applied the high-throughput pooled sequencing approach to the determination of neuropteran mitogenomes. Four complete mitogenome sequences were obtained: Micromus angulatus (Hemerobiidae), Chrysoperla nipponensis (Chrysopidae), Rapisma sp. (Ithonidae), and Thaumatosmylus sp. (Osmylidae). This allowed us to sample more complete mitochondrial RNA gene sequences. Secondary structure diagrams for the complete mitochondrial small and large ribosomal subunit RNA genes of eleven neuropterid species were predicted. Comparative analysis of the secondary structures indicated a closer relationship of Megaloptera and Neuroptera. This result was congruent with the resulting phylogeny inferred from sequence alignments of all 37 mitochondrial genes, namely the hypothesis of (Raphidioptera + (Megaloptera + Neuroptera)).
Real-time statistical detection and identification of sensor incipient fault using Kalman filter

This article describes a real-time statistical approach of fault detection for linear time-invariant (LTI) system subject to incipient fault profile. The proposed methodology combines Kalman filter for fault detection index generation and Generalized Likelihood Ratio (GLR) test that cancels out the monitored fault effect dynamics. Maximum Likelihood Estimation (MLE) has been used for signature correlation, statistical distance measure between defined hypotheses and estimation of an unknown parameter to carry out fault identification. To illustrate the effectiveness of proposed method numerical results for temperature sensor incipient fault detection and identification have been presented for a pressurizer of the Pressurized Water Reactor (PWR).
Prevalence of reduced kidney function and albuminuria in older adults: the Berlin Initiative Study

Background Although CKD is said to increase among older adults, epidemiologic data on kidney function in people ≥70 years of age are scarce. The Berlin Initiative Study (BIS) aims to fill this gap by evaluating the CKD burden in older adults. Methods The BIS is a prospective population-based cohort study whose participants are members of Germany's biggest insurance company. This cross-sectional analysis (i) gives a detailed baseline characterization of the participants, (ii) analyses the representativeness of the cohort's disease profile, (iii) assesses GFR and albuminuria levels across age categories, (iv) associates cardiovascular risk factors with GFR as well as albuminuria and (v) compares means of GFR values according to different estimating equations with measured GFR. Results A total of 2069 participants (52.6% female, mean age 80.4 years) were enrolled: 26.1% were diabetic, 78.8% were on antihypertensive medication, 8.7% had experienced a stroke, 14% a myocardial infarction, 22.6% had cancer, 17.8% were anaemic and 26.5% were obese. The distribution of comorbidities in the BIS cohort was very similar to that in the insurance 'source population'. Creatinine and cystatin C as well as the albumin:creatinine ratio (ACR) increased with increasing age. After multivariate adjustments, reduced GFR and elevated ACR were associated with most cardiovascular risk factors. The prevalence of a GFR <60 mL/min/1.73 m 2 ranged from 38 to 62% depending on the estimation equation used. Conclusions The BIS is a very well-characterized, representative cohort of older adults. Participants with an ACR ≥30 had significantly higher odds for most cardiovascular risk factors compared with an ACR <30 mg/g. Kidney function declined and ACR rose with increasing age.
Media Smart‐Targeted: Diagnostic outcomes from a two‐country pragmatic online eating disorder risk reduction trial for young adults

BACKGROUND Diagnostic outcomes in eating disorder (ED) risk reduction trials are important but rarely reported. METHODS An online pragmatic randomized-controlled trial was conducted with young-adult women in Australia and New Zealand seeking to improve their body image. Media Smart-Targeted (MS-T) was a 9-module program released weekly while control participants received tips for positive body image. Eating Disorder Examination-Questionnaire (EDE-Q) scores from baseline and 12-month follow-up were used to investigate two outcomes: ED onset in those who were asymptomatic at baseline (prevention effects); and, ED remission in those who met diagnosis at baseline (treatment effects). RESULTS MS-T participants were 66% less likely than controls to develop an ED by 12-month follow-up (nonsignificant). MS-T participants who met ED criteria at baseline were 75% less likely than controls to still meet diagnostic criteria at follow-up. This effect was significant and remained so for both those who did and who did not access external face-to-face ED treatment during the trial. CONCLUSIONS While further investigations are necessary, MS-T has fully automated procedures, low implementation costs, the potential to be delivered at-scale to assist those assist those where face-to-face services are limited or not available (e.g., remote areas).
Prevalence and Natural History of Superficial Siderosis: A Population-Based Study

Background and Purpose— Superficial siderosis (SS) is characterized by hemosiderin deposition in the superficial layers of the central nervous system and can be seen during postmortem examination or with iron-sensitive magnetic resonance imaging techniques. The distribution of SS may predict the probable underlying cause. This study aimed to report the prevalence and natural history of SS in a population-based study. Methods— Brain magnetic resonance imaging scans from the MCSA (Mayo Clinic Study of Aging), a population-based study of residents 50 to 89 years of age in Olmsted County, Minnesota, were reviewed. Participants with imaging consistent with SS were identified from 2011 through 2016. An inverse probability weighting approach was used to convert our observed frequencies to population prevalence of SS. Additional data abstracted included amyloid positron emission tomography, Apolipoprotein E genotype, coexisting cerebral microbleeds, and extent of SS. Results— A total of 1412 participants had eligible magnetic resonance imaging scans. Two participants had infratentorial SS, restricted to the posterior fossa. Thirteen participants had cortical SS involving the cerebral convexities (7 focal and 6 disseminated). Only 3 of the participants with cortical SS (23%) also had cerebral microbleeds. The population prevalence of SS was 0.21% (95% confidence interval, 0–0.45) in those 50 to 69 years old and 1.43% (confidence interval, 0.53–2.34) in those over 69 years old. Apolipoprotein E &egr;2 allele was more common in those with SS (57.1% versus 15.0%; P<0.001). Compared with participants without SS, those with SS were also more likely to have a positive amyloid positron emission tomographic scan (76.9% versus 29.8%; P<0.001). Conclusions— SS may be encountered in the general elderly population. The association with increased amyloid burden and Apolipoprotein E &egr;2 genotype supports cerebral amyloid angiopathy as the most common mechanism. Longitudinal follow-up is needed to evaluate the risk of subsequent hemorrhage in cases of incidentally discovered SS.
MicroRNA-125a-5p Mediates 3T3-L1 Preadipocyte Proliferation and Differentiation

Excessive accumulation of adipose tissue is a main cause of obesity or overweight, which is significantly involved in increasing the risk of diseases. Recently, numerous studies have proved that microRNAs (miRNAs) play important roles in adipogenesis by negatively regulating gene expression at posttranscriptional levels. In this study, we showed that miR-125a-5p was expressed at lower levels in the adipose tissues of high-fat diet (HFD)-fed mice than the normal chow (NCW)-fed mice. MiR-125a-5p expression were strongly up-regulated by nearly five-fold, when 3T3-L1 preadipocyte were induced and differentiated into mature adipocytes. Functional analysis indicated that overexpression of miR-125a-5p promoted 3T3-L1 preadipocyte proliferation and inhibited its differentiation. By contrast, inhibition of miR-125a-5p repressed 3T3-L1 preadipocyte proliferation and accelerated its differentiation. Furthermore, a dual-luciferase reporter assay demonstrated that signal transducer and activator of transcription 3 (STAT3) is a direct target gene of miR-125a-5p during 3T3-L1 preadipocyte differentiation. Further analysis confirmed that the process of miR-125a-5p inhibiting 3T3-L1 preadipocyte differentiation might be associated with the regulation of fatty acid metabolism related genes. Taken together, our results indicated that miR-125a-5p might promote 3T3-L1 preadipocyte proliferation, whereas inhibiting 3T3-L1 preadipocyte differentiation by negatively regulating STAT3.