Miracle-dz/UniFAR-FTUs huggingface dataset:
An Observer-Based Optimal Voltage Control Scheme for Three-Phase Three Level UPS Systems

Uninterrupted Power Supply (UPS) system supplies required power in case of utility power failures. UPS system has got significant importance in the field of industrial electronics due to increase in technology of power electronic devices.This paper proposes a Neutral Point Clamped (NPC) inverter with simple Sinusoidal Pulse Width Modulation Technique (SPWM), which is well suitable for inverter control. The proposed system would be subjected to fast transient response, small steady state error and low harmonic distortion test under different load conditions. Finally, the comparative results for the proposed scheme and the observer based voltage control scheme are presented to show that the proposed scheme achieves better performance. The results are tested and verified through MATLAB/Simulink. The proposed methodology reduces the total cost, complexity and THD .
Ontology-based learning content repurposing

This paper investigates basic research issues that need to be addressed for developing an architecture that enables repurposing of learning objects in a flexible way. Currently, there are a number of Learning Object Content Models (e.g. the SCORM Content Aggregation Model) that define learning objects and their components in a more or less precise way. However, these models do not allow repurposing of fine-grained components (sentences, images). We developed an ontology-based solution for content repurposing. The ontology is a solid basis for an architecture that will enable on-the-fly access to learning object components and that will facilitate repurposing these components.
Charge dynamics in polymeric materials and its relation to electrical ageing

Electrical Engineering should face the challenge of developing a mature approach in insulation design. Modeling charge transport and linking charge dynamics with dissipative processes responsible for electrical ageing are crucial as regards this objective. Such an approach is exemplified here for polyethylene-based materials by introducing two models describing bipolar Space Charge Limited Current in transient and steady states. They rely on two classical descriptions of the distribution function of the energy levels of trap states - single trapping level or exponential distribution. Their predictions are discussed as regards the experimental behavior. They notably highlight the importance of recombination processes in explaining the sigmoidal shape of the steady-state current-voltage characteristic and explain the development of oscillatory charge packets. The energetic features of charge dynamics is considered through the recombination of charges leading to electroluminescence. The spectral analysis of the emitted light advocates the existence of massive chemical/physical degradation in the electrical regime where recombination is a major factor of the Space Charge Limited Current (SCLC).
N conjugative transfer system of plasmid pCU1

The mating and plasmid DNA transfer functions in Escherichia coli K-12 strains that are determined by the IncN group plasmid pCU1 are specified by a single 19.4-kilobase (kb) segment of the 39-kb plasmid. Analysis of this tra region by transposon Tn5 mutagenesis and by complementation tests indicated that a subset of tra comprising six complementation groups (presumably transcription units) determines sensitivity to the N pilus-specific bacteriophages IKe and PRD1. Deletion derivatives and molecular clones that contained only this part of tra conferred sensitivity to IKe and PRD1 and the ability to produce N pili without conferring the Tra phenotype. The entire tra region contained two other complementation groups. If the 19.4-kb tra region is interrupted by DNA that is irrelevant to the Tra phenotype, such DNA must be less than 2 kb long. There are two regions within tra where this is a possibility. These observations are compared with those obtained recently with a related plasmid.
On The Latest Three‐Stage Development of Nanomedicines based on Upconversion Nanoparticles

Following the “detect‐to‐treat” strategy, by biological engineering, the emerging upconversion nanoparticles (UCNPs) have become one of the most promising inorganic nanomedicines, and their biomedical applications have gradually shifted from multimodal tumor imaging to highly efficient cancer therapy. The past few years have witnessed a three‐stage development of UCNP‐based nanomedicines. On one hand, UCNPs can optimize each clinical treatment tool (chemotherapy, photodynamic therapy (PDT), radiotherapy (RT)) by controlled drug delivery/release, near‐infrared (NIR)‐excited deep PDT, and radiosensitization, respectively, all of which contribute greatly to the optimized treatment efficacy along with minimized side effects. On the other hand, several individual treatments can be “smartly” integrated into a single UCNP‐based nanotheranostic system for multimodal synergetic therapy, which can further improve the overall therapeutic effectiveness. Especially, UCNPs provide more‐effective strategies for overcoming tumor hypoxia, thus leading to an ideal treatment efficacy for complete eradication of solid tumors. Finally, the critical issues regarding the future development of UCNPs are discussed to promote the clinic‐translational applications of UCNP‐based nanomedicines, as well as realization of our “one drug fits all” dream.
Gender differences among discrimination & stigma experienced by depressive patients in Pakistan

Objective: This study aims to examine Gender Difference in the level of Discrimination and Stigma experienced by people diagnosed with Major Depressive Disorder in Pakistan. It was hypothesized that Women diagnosed with Depression are likely to be experiencing more Discrimination and Internalized Stigma in comparison to Men. Methods: This is a Cross Sectional Study. Thirty eight patients diagnosed with Major Depressive Disorder recruited from different Government Sector Hospitals of Lahore; were approached after obtaining informed consent. Discrimination and Stigma were measured through Discrimination and Stigma Scale and Internalized Stigma of Mental Illness Inventory respectively. Results: Both Men and Women experience considerably high level of associated Stigma and Discrimination due to their Mental Illness. However, Women in comparison to Men experience significantly greater level of Internalized Stigma especially in domains of Discrimination Experience and Social Withdrawal. Conclusion: The findings of this study highlight the fact that people with Depression can be more benefited with psychological treatment if dealing with Stigma and Discrimination is also addressed in Intervention Plans.
Drug-induced steatohepatitis

ABSTRACT Introduction: Drug induced steatohepatitis (DISH), a form of drug induced liver injury (DILI) is characterized by intracellular accumulation of lipids in hepatocytes and subsequent inflammatory events, in some ways similar to the pathology seen with other metabolic, viral and genetic causes of non alcoholic fatty liver disease and steatohepatitis (NAFLD and NASH). Areas covered: This paper provides a comprehensive review of the main underlying mechanisms by which various drugs cause DISH, and outlines existing preclinical tools to predict it and study underlying pathways involved. The translational hurdles of these models are discussed, with the example of an organotypic liver system designed to address them. Finally, we describe the clinical assessment and management of DISH. Expert Opinion: The complexity of the interconnected mechanistic pathways underlying DISH makes it important that preclinical evaluation of drugs is done in a physiologically and metabolically relevant context. Advanced organotypic tissue models, coupled with translational functional biomarkers and next-generational pan-omic measurements, may offer the best shot at gathering mechanistic knowledge and potential of a drug causing steatohepatitis. Ultimately this information could also help predict, detect or guide the development of specific treatments for DISH, which is an unmet need as of today.
Learning Search Control for Constraint-Based Scheduling

This paper describes an application of an analytical learning technique, Plausible Explanation-Based Learning (PEBL), that dynamically acquires search control knowledge for a constraint-based scheduling system. In general, the efficiency of a scheduling system suffers because of resource contention among activities. Our system learns the general conditions under which chronic contention occurs and uses search control to avoid repeating mistakes. Because it is impossible to prove that a chronic contention will occur with only one example, traditional EBL techniques are insufficient. We extend classical EBL by adding an empirical component that creates search control rules only when the system gains enough confidence in the plausible explanations. This extension to EBL was driven by our observations about the behavior of our scheduling system when applied to the real-world problem of scheduling tasks for NASA Space Shuttle payload processing. We demonstrate the utility of this approach and provide experimental results.
Gender dimorphism of body mass perception and regulation in mice

SUMMARY According to the set-point theory of body mass, changes in body mass are perceived by the body, leading to activation of compensatory feedback mechanisms, which in turn restores the set-point body mass. However, this theory is still under debate. To test if mass per se might be sensed and regulated, we implanted loads corresponding to 10% (HI) or 2% (LO, control) of body mass into mice in addition to sham-operated mice (SO). We recorded body mass, food intake, energy expenditure and body composition over 14 weeks. Both male and female mice showed an initial stress-induced loss of body mass, which was more pronounced in males. Subsequently, male HI mice displayed a permanently decreased biological body mass (MBB, body mass exclusive of the implant mass), equivalent to approximately half of the mass of the implant, and obtained by a decrease in fat mass compared to SO males. In contrast, female HI mice rapidly recovered and maintained their initial MBB and body composition following a mass load. Initial lean body mass was maintained in all male and female groups, and energy intake was similar in all male and female groups. Body mass changes could not be explained by measurable changes in energy intake or expenditure. We conclude that changes in body mass are perceived and partially compensated in male but not in female mice, suggesting that mass-specific regulation of body mass might not play a major role in overall body mass regulation. Different compartments of the body are possibly regulated by different signals and stimuli. Our results suggest that lean body mass rather than body mass per se seems to be tightly regulated. Higher efficiency of energy utilization in females compared to males could explain the gender-specific changes in energy balance.
The TetA(K) Tetracycline/H+ Antiporter from Staphylococcus aureus: Mutagenesis and Functional Analysis of Motif C

ABSTRACT Conserved motif C, identified within members of the major facilitator superfamily (MFS) of transport proteins that mediate drug export, was examined in the tetracycline resistance efflux protein TetA(K) from Staphylococcus aureus; motif C is contained within transmembrane segment 5. Using site-directed mutagenesis, the importance of the conserved glycine (G151, G155, G159, and G160) and proline (P156) residues within this motif was investigated. Over 40 individual amino acid replacements were introduced; however, only alanine and serine substitutions for glycine at G151, G155, and G160 were found to retain significant levels of tetracycline resistance and transport activity in cells expressing mutant proteins. Notably, P156 and G159 appear to be crucial, as amino acid replacements at these positions either significantly reduced or abolished tetracycline/H+ activity. The highly conserved nature of motif C and its distribution throughout drug exporters imply that the residues of motif C play a similar role in all MFS proteins that function as antiporters.
Marital Status and Cancer Incidence : Differences in the Black and White Populations 1

A study of 59,070 cancers newly diagnosed during the years 1978 through 1982 among black and white males and females was conducted to assess variations in age-adjusted incidence rates across four marital categories, single, married, divorced, and widowed. Population data were obtained from the 1980 Census. Distinct patterns of cancer incidence by marital status were observed for black and white males and females. Single black males had the highest age-adjusted incidence rates for all 15 of the 15 sites analyzed among men. Similarly single black females' rates were highest for 14 of the 18 sites analyzed among women. Among white females, age-adjusted incidence rates were highest or second highest in widows for 16 of 18 sites analyzed. The variation in cancer incidence by marital status was not statistically significant for white men. In addition, there is a statistically significant concordance of cancer incidence by marital status across the four race-gender groups for three digestive tract sites. Clues to cancer etiology are suggested by this study, as well as potential directions for preventive health programs.
ProMIS Augmented Reality Training of Laparoscopic Procedures Face Validity

Background: Conventional video trainers lack the ability to assess the trainee objectively, but offer modalities that are often missing in virtual reality simulation, such as realistic haptic feedback. The ProMIS augmented reality laparoscopic simulator retains the benefit of a traditional box trainer, by using original laparoscopic instruments and tactile tasks, but additionally generates objective measures of performance. Methods: Fifty-five participants performed a “basic skills” and “suturing and knot-tying” task on ProMIS, after which they filled out a questionnaire regarding realism, haptics, and didactic value of the simulator, on a 5-point-Likert scale. The participants were allotted to 2 experience groups: “experienced” (>50 procedures and >5 sutures; N = 27), and “moderately experienced” (<50 procedures and <5 sutures; N = 28). Results: General consensus among all participants, particularly the experienced, was that ProMIS is a useful tool for training (mean: 4.67, SD: 0.48). It was considered very realistic (mean: 4.44, SD: 0.66), with good haptics (mean: 4.10, SD: 0.97) and didactic value (mean 4.10, SD: 0.65). Conclusions: This study established the face validity of the ProMIS augmented reality simulator for “basic skills” and “suturing and knot-tying” tasks. ProMIS was considered a good tool for training in laparoscopic skills for surgical residents and surgeons.
Drosophila javelin-like encodes a novel microtubule-associated protein and is required for mRNA localization during oogenesis

Asymmetrical localization of mRNA transcripts during Drosophila oogenesis determines the anteroposterior and dorsoventral axes of the Drosophila embryo. Correct localization of these mRNAs requires both microtubule (MT) and actin networks. In this study, we have identified a novel gene, CG43162, that regulates mRNA localization during oogenesis and also affects bristle development. We also showed that the Drosophila gene javelin-like, which was identified based on its bristle phenotype, is an allele of the CG43162 gene. We demonstrated that female mutants for jvl produce ventralized eggs owing to the defects in the localization and translation of gurken mRNA during mid-oogenesis. Mutations in jvl also affect oskar and bicoid mRNA localization. Analysis of cytoskeleton organization in the mutants reveal defects in both MT and actin networks. We showed that Jvl protein colocalizes with MT network in Schneider cells, in mammalian cells and in the Drosophila oocyte. Both in the oocyte and in the bristle cells, the protein localizes to a region where MT minus-ends are enriched. Jvl physically interacts with SpnF and is required for its localization. We found that overexpression of Jvl in the germline affects MT-dependent processes: oocyte growth and oocyte nucleus anchoring. Thus, our results show that we have identified a novel MT-associated protein that affects mRNA localization in the oocyte by regulating MT organization.
A CONSTRUÇÃO DE MAQUETES COMO RECURSO DIDÁTICO NO ENSINO DE GEOGRAFIA

É imprescindível para a formação contínua dos professores de geografia, uma profunda reflexão a respeito da geografia contemporânea e os seus novos desafios. Esse exercício reflexível serve e contribui na formação dos alunos em pessoas participativas e críticas da sua realidade. Sabendo do papel da didática e seus recursos, utilizou-se desse conhecimento para propor um exercício didático e lúdico no ensino de geografia, facilitando, assim, aos alunos a apropriação de conteúdo, associando-os à responsabilidade social que cada indivíduo terá no viver em sociedade. O presente trabalho relata a construção supervisionada de maquetes realizada durante uma aula sobre a temática do efeito estufa juntamente com os alunos do 9º ano no Colégio Lima Silva em Fortaleza, Ceará. As maquetes foram apresentadas em uma feira de ciências realizada na escola e houveram muitos elogios dos espectadores. Com esse estudo foi possível concluir que a construção da maquete permite ao aluno relacionar o conteúdo dado em sala de aula a algo palpável do seu cotidiano, despertando um maior interesse por parte dos mesmos na disciplina de Geografia.
Off-Target Gene Regulation Mediated by Transcriptional Repressors of Antimicrobial Efflux Pump Genes in Neisseria gonorrhoeae

ABSTRACT DNA-binding proteins that control expression of drug efflux pump genes have been termed “local regulators” as their encoding gene is often located adjacent to the gene(s) that they regulate. However, results from recent studies indicate that they can control genes outside efflux pump-encoding loci, which we term as being “off target. ” For example, the MtrR repressor was initially recognized for its ability to repress transcription of the mtrCDE-encoded efflux pump operon in the strict human pathogen Neisseria gonorrhoeae, but recent results from genetic and microarray studies have shown that it can control expression of nearly 70 genes scattered throughout the chromosome. One of the off-target MtrR-repressed genes is glnA, which encodes glutamine synthetase. Herein, we confirm the capacity of MtrR to repress glnA expression and provide evidence that such repression is due to its ability to negatively influence the binding of a second DNA-binding protein (FarR), which activates glnA. FarR was previously recognized as a transcriptional repressor of the farAB-encoded efflux pump operon. Thus, two DNA-binding proteins previously characterized as repressors of genes encoding efflux pumps that contribute to gonococcal resistance to antimicrobials can act in an opposing manner to modulate expression of a gene involved in basic metabolism.
Intelligent System Design for Stator Windings Faults Diagnosis: Suitable for Maintenance Work

The short circuit is a severe fault that occurs in the stator windings. Therefore, it is very important to diagnose this type of failure in its beginning before it causes unscheduled stop and the machine loss. In this context, the Support Vector Machine (SVM) is a tool of considerable importance for standard classification. From some training data, it can diagnose whether or not there is a short circuit beginning, and which is important for predictive maintenance. This work proposes a technique for early detection of a short circuit between the turns aiming at its implementation in a real plant. The paper shows simulation and experimental results, and validates the proposed technique.
Topic life cycle extraction from big Twitter data based on community detection in bipartite networks

This paper is showing a time series topic life cycle extraction from millions of Tweets using our original community detection technique in bipartite networks. We suppose that the authors role that means who belong to what topics is important to extract quality topics from social media data. We already proposed the topic extraction method that considers the relationship between the authors and the words as bipartite networks and explores the authors role by forming clusters as topics. As the next step, this paper applies our method to the time series topic life cycle detection. We extract topics in different time slots and analyze the time series of topic transition using the coherence measure that expresses the semantic accuracy of topics. The paper demonstrates that our method can detect the topic life cycle such as the growth, the conflicts and so on over time from millions of Tweets.
{N,N′-Bis[1-(pyridin-2-yl)ethylidene]propane-1,3-diamine}(thiocyanato-κN)copper(II) tetrafluoridoborate

In the title compound, [Cu(NCS)(C17H20N4)]BF4, the CuII ion is five-coordinated by the four N atoms of the tetradentate Schiff base ligand and one N atom of a thiocyanate ligand, thereby forming a square-pyramidal CuN5 ccoordination geometry. The dihedral angle between the pyridine rings of the Schiff base is 55.58 (14)°. The F atoms of the tetrafluoridoborate anion are disordered over two sets of sites with occupancies of 0.614 (3) and 0.386 (3). In the crystal, the components are linked by C—H⋯F interactions.
Cross-national comparisons of the Cambridge Cognitive Examination-revised: the CAMCOG-R: results from the European Harmonization Project for Instruments in Dementia.

BACKGROUND Transnational and psychometrically appropriate versions of instruments used in the diagnosis of dementia are essential for comparing information between different countries. The Cambridge Examination for Mental Disorders of the Elderly incorporates a brief neuropsychological test battery, Cambridge Cognitive Examination (recently revised version), which provides objective data on performance across a number of cognitive domains. OBJECTIVE To harmonise the Cambridge Cognitive Examination between seven European countries. METHOD 40 patients with probable or possible Alzheimer's disease of each of the seven countries were administered the Cambridge Cognitive Examination. The Nurse Observation Scale for Geriatrics was used to assess concordance between cognitive and behavioural measures. RESULTS Only small differences between the various Cambridge Cognitive Examination versions were found, and patterns of correlation between Cambridge Cognitive Examination and the Nurse Observation Scale for Geriatrics were consistent. CONCLUSION These findings indicate that the harmonisation of the Cambridge Cognitive Examination was successful.