Miracle-dz/UniFAR-FTUs huggingface dataset:
A Resistance-Nodulation-Cell Division Family Xenobiotic Efflux Pump in an Obligate Anaerobe, Porphyromonas gingivalis

ABSTRACT Porphyromonas gingivalis, a gram-negative obligate anaerobe, contains two homologs of an Escherichia coli resistance-nodulation-cell division-type multidrug exporter gene, acrB, in putative operons, together with homologs of membrane fusion protein gene acrA and outer membrane channel gene tolC. MIC determination and accumulation assays with mutants with disruptions of one or more genes showed that one cluster, named xepCAB, pumped out multiple agents including rifampin, puromycin, and ethidium bromide.
Conditions de vie et lieu de résidence

Dans la perspective du retour ou du maintien dans la communaute des personnes qui ont des problemes severes de sante mentale, le logement apparait d'emblee comme un point critique. Jusqu'ici, la litterature specialisee a surtout porte sur la description et l'evaluation de differents programmes residentiels de readaptation. Rarement a-t-on cherche a connaitre les conditions de vie des personnes psychiatrisees et leur opinion sur leur milieu de vie. A partir d'une recherche conduite aupres de 151 personnes avant deja ete hospitalisees en psychiatrie, cet article fait etat des conditions de vie de ces personnes en regard de leur type de residence. Les donnees de l'enquete permettent 1) de mettre en rapport differents types d'arrangement residentiel avec les caracteristiques socio-demographiques et cliniques des personnes, et 2) de considerer l'impact du type de residence sur d'autres domaines de la vie. Ces informations sont ensuite mises en relation avec l'evaluation subjective que les personnes font de leurs conditions de vie.
Value of spontaneous hyperdensity of cerebral venous thrombosis on helical CT

Background Excluding a cerebral venous thrombosis (CVT) through imaging is a frequent request in the emergency setting. This assessment often starts by an unenhanced brain computed tomography (CT). Purpose Re-evaluate the value of spontaneous hyperdensity of CVT on helical unenhanced brain CT. Methods Multicentric retrospective study on CVT probability based on visual assessment of spontaneous hyperdensity of cerebral venous system, performed by four blinded radiologists, individually then collectively, on a population including 14 helical unenhanced brain CTs with CVT and 102 unenhanced brain CTs without CVT (all confirmed by CT or magnetic resonance [MR] venography). Exclusion criteria: no DICOM image, symptoms >15 days, CVT indirect signs on unenhanced CT. A fifth radiologist set 768 regions of interest to measure and to compare the density within the normal venous sinuses and the CVTs. Results After consensus reading, sensitivity of this sign for CVT diagnosis was 100%, specificity 95.1%, and negative predictive value (NPV) 100%, with high individual NPV (99–100%). Area under the receiver-operating characteristic curve was 0.992 after consensus (0.976–0.986 individually). The spontaneous density was significantly different (P <0.05) between normal sinuses and CVTs, with a density >70 HU reported only within the CVTs, except for the horizontal part of the superior sagittal sinus (hSSS). Conclusion The dense triangle sign on helical unenhanced brain CT has an excellent NPV to exclude a sinus thrombosis during the first 2 weeks. However, we believe that visual assessment of spontaneous hyperdensity is not sufficient for the diagnosis of CVT, with possible false-positive of the hSSS on unenhanced CT.
Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.

Progressive destruction of the insulin-producing beta cells in nonobese diabetic mice is observed after infiltration of the pancreas with lymphocytes [Makino, S. , Kunimoto, K. , Muraoka, Y. , Mizushima, Y. , Katagiri, K. & Tochino, Y. (1980) Exp. Anim. (Tokyo) 29, 1-13]. We show that the genes for tumor necrosis factor alpha and granzyme A, a serine protease associated with cytoplasmic granules of cytotoxic cells, are expressed during the development of spontaneous diabetes mellitus in the nonobese diabetic mouse. Granzyme A-positive cells are found both in and surrounding the islets, implying induction prior to islet infiltration. Tumor necrosis factor alpha expression is exclusively observed in the intra-islet infiltrate, predominantly in lymphocytes adjacent to insulin-producing beta cells, the targets of the autoimmune destruction, implying that tumor necrosis factor alpha expression is induced locally--i.e., in the islet. A considerable portion of cells expressing tumor necrosis factor alpha appear to be CD4+ T cells. This T-cell subset was previously shown to be necessary for development of the disease. Thus, these findings may be important for understanding the pathogenesis of autoimmune diabetes mellitus and potentially also for that of other T-cell-mediated autoimmune diseases.
The Role of Information-Processing Capacity and Goals in Attitude-Congruent Selective Exposure Effects

Two experiments explored the role of information-processing capacity and strategies in regulating attitude-congruent selective exposure. In Experiment 1, participants were placed under time pressure and randomly assigned to conditions in which either an attitude-expressive or no-information processing goal was made salient. Analyses revealed an attitude-congruent selective exposure effect and indicated that this effect was stronger when an attitude-expressive goal was made salient than when no goal was made salient. In Experiment 2, information-processing goals and time pressure were factorially manipulated. Analyses revealed an attitude-congruent selective exposure effect and indicated that this effect was especially strong when time pressure was high and an attitude-expressive goal was made salient. In both experiments, bias at exposure was found to predict bias at later stages of information processing (attention and memory). Supplementary analyses and data confirmed that the attitude-expressive goal manipulation activated its intended motivational processing strategy.
Energized mitochondria increase the dynamic range over which inositol 1,4,5‐trisphosphate activates store‐operated calcium influx

In eukaryotic cells, activation of cell surface receptors that couple to the phosphoinositide pathway evokes a biphasic increase in intracellular free Ca2+ concentration: an initial transient phase reflecting Ca2+ release from intracellular stores, followed by a plateau phase due to Ca2+ influx. A major component of this Ca2+ influx is store‐dependent and often can be measured directly as the Ca2+ release‐activated Ca2+ current (ICRAC). Under physiological conditions of weak intracellular Ca2+ buffering, respiring mitochondria play a central role in store‐operated Ca2+ influx. They determine whether macroscopic ICRAC activates or not, to what extent and for how long. Here we describe an additional role for energized mitochondria: they reduce the amount of inositol 1,4,5‐trisphosphate (InsP3) that is required to activate ICRAC. By increasing the sensitivity of store‐operated influx to InsP3, respiring mitochondria will determine whether modest levels of stimulation are capable of evoking Ca2+ entry or not. Mitochondrial Ca2+ buffering therefore increases the dynamic range of concentrations over which the InsP3 is able to function as the physiological messenger that triggers the activation of store‐operated Ca2+ influx.
Silicon-based silicon–germanium–tin heterostructure photonics

The wavelength range that extends from 1550 to 5000 nm is a new regime of operation for Si-based photonic and opto-electronic integrated circuits. To actualize the new chips, heterostructure active devices employing the ternary SiGeSn alloy are proposed in this paper. Foundry-based monolithic integration is described. Opportunities and challenges abound in creating laser diodes, optical amplifiers, light-emitting diodes, photodetectors, modulators, switches and a host of high-performance passive infrared waveguided components.
Regular behavior measure for location based services

We introduce a method that can measure the degree of regularity or irregularity of the behavior for enhancing the performance of location-based services (LBSs) such as check-in. It is still challenging for LBSs to determine the places to recommend that best suits the user's needs. Our aim is to identify the user's status (regular or irregular) of each check-in. Most previous studies approached this problem by acquiring usual locations (e.g., home or office) or assessing check-in frequency. We propose more effective measure by using a multinomial-distribution-based method that considers the periodic check-ins of the user on various time-scales. Our method can accurately identify irregular check-ins even in usual locations and we find that the users tend to continue irregular check-ins in a certain range of time.
Information Hiding with Optimal Detector for Highly Correlated Signals

In this paper, a novel scaling based information hiding approach robust against noise and gain attack is presented. The host signal is assumed to be stationary Gaussian modeled with a first-order autoregressive process. For data embedding, the host signal is divided into two parts. One part is manipulated while the other part is kept unchanged for parameter estimation. The decoding scheme using the ratio of samples is suitable for highly correlated signals in which the decoding process is difficult. By calculating the distribution of the ratio, the performance of the maximum likelihood decoder is analytically studied. The proposed algorithm is applied to several artificial Gaussian autoregressive signals to verify the validity of our results.
[Phase II study].

It is 4 years since the Ministry of Health and Welfare of Japan introduced "The Guidelines on Clinical Evaluation for Anti-tumor Drugs" in February 1991. From the stand point that I have conducted several clinical studies on new anti-tumor drugs according to the Guidelines, this review pointed out some practical problems in the process to develop Phase II study based on the Guidelines.
Turbo decoder for high-speed application in wideband-code division multiple access system

Implementation of a turbo decoder for high-speed application in W-CDMA (wideband-code division multiple access) systems and its performance are described As an implementation of the max-log-MAP (maximum a posteriori) algorithm for the turbo decoder, we propose what we call a "stepping-stone-max-log-MAP" (SS-max-log-MAP) algorithm that reduces memory size in the turbo decoder without loss of performance compared to the ordinal max-log-MAP algorithm, even when bit puncturing is used to adjust transmission data rate. Performance evaluation of the SS-max-log-MAP turbo decoder is also described when applied to a high-speed data channel in W-CDMA.
Design Of Ternary Logic Gates Using CNTFET

This paper presents a novel design of ternary logic gates like STI,PTI,NTI,NAND and NOR using carbon nanotube field effect transistors. Ternary logic is a promising alternative to the conventional binary logic design technique, since it is possible to accomplish simplicity and energy efficiency in modern digital design due to the reduced circuit overhead such as interconnects and chip area. In this paper novel design of basic logic gates for ternary logic based on CNTFET, is proposed.
Analysis of micro-motion model for radar target

The mechanical dynamics in addition to its bulk translation of the target or any structure on the target is called micro-motion. Micro-motion evokes a frequency modulation in radar echo known as micro-Doppler (m-D) effect which may help to detect specific structures of a target with micro-motion, leading a potential way to realize target identification by extracting the micro-Doppler features. In most literatures, the micro-motions were modeled as the sinusoidal forms. In fact the micro-motions in reality should include more types of movement forms besides the sinusoidal one. This paper derives the foundation of universal micro-motion model for radar target other than the popular sinusoidal model. The mathematical formulas of micro-Doppler induced by targets with arbitrary micro-motion are derived, and some examples of several basic and typical micro-motion types (vibration, rotation, sinusoidal, pendulum) are given. At last the simulation studies based on the point scattering model are conducted to validate the proposed theoretical model.
The complete mitochondrial genome of Hemiodoecus leai (Hemiptera: Coleorrhyncha: Peloridiidae)

Abstract The mitochondrial genome of Hemiodoecus leai (Hemiptera: Coleorrhyncha: Peloridiidae) was determined and annotated. The entire genome was 15,949 bp in length, containing 37 genes of 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes and an A + T-rich region. The genome has a gene arrangement identical to the inferred ancestral insects. Twelve of the 13 PCGs initiate with the standard start codons ATN, whereas CO1 starts with CGA. The tRNAs have be folded into typical cloverleaf secondary structures, except that the stem of the DHU arm was absent in tRNASer(GCT). The non-coding AT-rich region is 1414 bp long and is located between the rrnS and tRNAlle genes. The complete mitogenome sequence of H. leai could provide fundamental data for the phylogenetic and biogeographic studies of the Peloriidae as well as the Coleorrhyncha and Hemiptera.
Studies on protein subunits. 3. Kinetic evidence for the presence of active subunits during the renaturation of muscle aldolase.

Abstract The renaturation of guanidinium chloride-denatured aldolase in buffer containing 20% sucrose at 0° can be resolved into two distinct processes by following the regain of activity. Initially, an active intermediate is formed which is unstable to treatment with 2.3 m urea. This intermediate is then converted into another active species which is stable to 2.3 m urea. Analysis of the kinetic data shows that the over-all process of reactivation is independent of the concentration of enzyme in the renaturation mixture whereas the rate of formation of 2.3 m urea-stable activity is highly concentration-dependent. The results are consistent with a model in which denatured aldolase refolds in a first order reaction to give active monomers which then associate in concentration-dependent steps to give active dimer, trimer, and tetramer. In this model, the activity of each subunit is the same whether it exists singly or as part of an oligomer. However, only the tetramer is stable to 2.3 m urea. This model is also supported by gel filtration studies of partially renatured aldolase. The results support our earlier observation based on matrix-bound aldolase subunits (Chan, W. W.-C. (1970) Biochem. Biophys. Res. Commun. , 41, 1198) that aldolase subunits are active but differ from the tetramer in being unstable toward 2.3 m urea.
Analysis of Transient Performance of Grounding System Considering Soil Ionization by Time Domain Method

The grounding system is very important for lightning protection. If the lightning current is large enough, soil will be ionized, which will have a great effect on the transient performance of the grounding system. In this paper, an efficient time domain method is proposed to analyze the transient performance of the grounding system. The method takes account of nonlinear soil ionization, the shielding effect among electrodes, and frequency-dependent parameters all together. First, a frequency domain circuit model is set up based on a moment method coupling with circuit theory. Then, the model is approximated by a frequency-independent circuit model with the help of vector fitting method. Finally, the time-varying soil ionization is considered by making corresponding parameters time-varying when a time domain method is used to solve the circuit model. The method is validated by field test.
Applying a Machine Learning Technique to Classification of Japanese Pressure Patterns

In climate research, pressure patterns are often very important. When a climatologists need to know the days of a specific pressure pattern, for example "low pressure in Western areas of Japan and high pressure in Eastern areas of Japan (Japanese winter-type weather)," they have to visually check a huge number of surface weather charts. To overcome this problem, we propose an automatic classification system using a support vector machine (SVM), which is a machine-learning method. We attempted to classify pressure patterns into two classes: "winter type" and "non-winter type". For both training datasets and test datasets, we used the JRA-25 dataset from 1981 to 2000. An experimental evaluation showed that our method obtained a greater than 0.8 F-measure. We noted that variations in results were based on differences in training datasets.
Sla1, a Schizosaccharomyces pombe Homolog of the Human La Protein, Induces Ectopic Meiosis when Its C Terminus Is Truncated

ABSTRACT Sla1 is a Schizosaccharomyces pombe homolog of the human La protein. La proteins are known to be RNA-binding proteins that bear conserved RNA recognition motifs (La and RRMs), but their biological functions still have not been fully resolved. In this study, we show that the S. pombe La homolog (Sla1) is involved in regulating sexual development. Sla1 truncated in the C terminus (Sla1ΔC) induced ectopic sporulation in the ras1Δ strain and several other sporulation-deficient mutants. The C terminus contains a nuclear localization signal. While full-length Sla1 localizes in the nucleus, Sla1ΔC is found throughout the cell, suggesting the cytoplasmic localization of Sla1ΔC is involved in its sporulation-inducing activity. Further deletion analysis of Sla1 indicated that a small region (35 amino acids) that includes a portion of RRM2 is sufficient to induce sporulation. The La motif (RRM1) is not involved in this activity. Strikingly, Sla1ΔC induced haploid meiosis in a heterothallic strain, similar to the pat1-114 or mei2-SATA mutation. Sla1ΔC induced sporulation in a mei3 disruptant but not in a mei2 disruptant, indicating that Sla1ΔC requires Mei2 to induce haploid meiosis. Deletion of the chromosomal sla1 gene lowered the temperature sensitivity of the pat1-114 mutant. Two-hybrid analysis indicated that Pat1 interacts with Sla1ΔC but not full-length Sla1. Thus, Sla1ΔC may block Pat1 activity. This block would remove the inhibition on Mei2, which would then drive the cell into haploid meiosis. Finally, Sla1 was degraded prior to the start of meiosis when we monitored Sla1 in cells in which meiosis was synchronously induced. The ability of truncated Sla1 to induce ectopic meiosis represents a very novel function that has hitherto not been suspected for the La family of proteins.
Humanitarian opportunities in the network age: Empowering disadvantaged communities

This research focuses on using technology to empower people at the bottom of the pyramid; how can they benefit from being online? And how can humanitarian technology address the challenges they face? Therefore, two distinct cases are explained. The first is initiating an income generating activity for women living in urban slum in Nairobi, Kenya. Although the outcome is a primitive approach, it highlights the necessity of utilizing technology in applying sustainable approaches for empowerment. This achievement leads to the second case; describing the context, methods and results of an ongoing project, in regards to implementing a technological empowering approach for disadvantaged and marginalized women in Iran. The project consists of three stages (1) educating (2) social collaboration (3) support. During the second phase, public community is engaged in a creative collaboration online platform to empower disadvantaged women. Applying technology as a collaborative platform, establishes an effective communication among different walks of life, which promotes the marginalized women dignity further to supplement the economical empowerment. These experiments revealed that the only way for solving disadvantaged communities' problems, is making its residents responsible for solving them. The emergence of technologies which make possible participatory systems at scale, paved the way for taking advantage of social networking and crowd wisdom. Hence, it is the right time to shift the humanitarian technology toward more holistic approaches. A connected marginalized community is more informed and has access to further resources which will facilitate and speed up the process of their sustainable and holistic empowerment.
Biosynthetic pathway to neuromelanin and its aging process

Using model compounds of the melanic component of neuromelanin (NM) prepared by tyrosinase oxidation at various ratios of dopamine (DA) and cysteine (Cys) under physiological conditions, we examined a biosynthetic pathway to NM and its aging process by following the time course of oxidation to NM and the subsequent structural modification of NM under various heating conditions. Chemical degradation methods were applied to the synthetic NM. 4‐Amino‐3‐hydroxyphenylethylamine (4‐AHPEA) and thiazole‐2,4,5‐tricarboxylic acid (TTCA) were used as markers of benzothiazine and benzothiazole units, respectively. By following the time course of the biosynthetic pathway of synthetic NM, we found that neurotoxic molecules are trapped in NM. An aging simulation of synthetic NM showed that benzothiazine units in NM are gradually converted to benzothiazole during the aging process. Thus, natural NM was found to be similar to aged (heated) NM prepared from a 2:1 molar ratio of DA and Cys.
Rotavirus impairs the biosynthesis of brush‐border‐associated dipeptidyl peptidase IV in human enterocyte‐like Caco‐2/TC7 cells

Rotavirus is the leading cause of severe dehydrating diarrhoea in infants and young children worldwide. This virus infects mature enterocytes in the small intestine, and induces structural and functional damage. In the present study, we have identified a new mechanism by which rotavirus impairs a brush border‐associated intestinal protein. We show that infection of enterocyte‐like Caco‐2/TC7 cells by rhesus monkey rotavirus (RRV) impairs the biosynthesis of dipeptidyl peptidase IV (DPP IV), an important hydrolase in the digestion of dietary proline‐rich proteins. We show that the enzyme activity of DPP IV was reduced, and that rearrangements of the protein occurred at the apical domain of the RRV‐infected cells. Using pulse‐chase experiments and cell surface immunoprecipitation, we have demonstrated that RRV infection did not affect the stability or apical targeting of DPP IV, but did induce a dramatic decrease in its biosynthesis. Using quantitative RT‐PCR, we showed that RRV had no effect on the level of expression of DPP IV mRNA, suggesting that the observed decrease in the biosynthesis of the protein is related to an effect of the virus at the translational level.
Photonic generation of chirp-free UWB signals for UWB over fiber applications

Highly chirped optical UWB pulses with wide optical spectral widths tend to be distorted by fiber dispersion, which is undesirable for UWB over fiber transmission systems. In this paper, we investigate theoretically and experimentally a method to generate in the optical domain stable chirp-free UWB signals with a narrow optical spectral width. The UWB pulse generator consists of a polarization modulator (PolM) and a polarization-maintaining fiber (PMF) based delay line. The generated UWB signals are transmitted over a 10- or 24-km optical standard single-mode fiber followed by a wireless link. Experimental results show that the system has a good tolerance to fiber dispersion.