Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on the Impact of Five Science and Technology Plans of Guangdong Province on Industrial Innovation Chain

The science and technology planning system is the basic form of government organization of scientific research and technology development activities. It is an action plan that affects the future development of science and technology and the related environment. It is also the government’s rational allocation of scientific and technological resources, regulation of market and scientific re-search, and promotion of scientific and technological progress. An effective means of economic and social development is one of the important tools in science and technology policy. This paper studies the science and technology policy of Guangdong Province, namely the “five major science and technolo-gy plans” from the perspective of industrial innovation chain. Firstly, it in-troduces the theory of industrial innovation chain; then studies the public goods, externalities and uncertainties in the industrial innovation chain of market failures; finally analyzing the role of the “Five Science and Technology Programs” in market failures in the industrial innovation chain.
Sensivity of Value Added Model Specifications : Measuring Socio-Economic Status

The paper describes the extent to which two different measures of Socio-Economic Status (SES) or the exclusion of that controlling variable from the Value Added Model (VAM) changes the estimates of school value added. The statistical model used to estimate the school value added is a variance component model where pupils are level one unit and schools are level two units. Prior achievement is included as explanatory variable as well. The data used in this paper is derived from a school effectiveness research project (Eficácia Escolar no Ensino da Matemática, 3EM project) and was collected in Cova da Beira (NUT III), Portugal. It is a longitudinal data set which allows pupils to be followed through their schooling. However, for the purpose of this paper, we only used the data collected at the beginning and at the end of the academic year 2005-06 for the 1, 3, 5, 7 and 8 grades. SES variables considered are: (1) The student eligibility for Free School Meals and Books (FSM); (2) Parent's education (parent responsible for the pupil). Evidence shows that prior achievement shrinks ESE effects. Results also show that value-models are sensible to the way achievement is measured, even when there is only one subject.
Evidence for Increased Apoptosis of Duodenal Intraepithelial Lymphocytes in Cow's Milk Sensitive Enteropathy

Objectives: Enterocyte apoptosis induced by activated intraepithelial lymphocytes (IELs) is increased in celiac disease (CD). A lesser increment in intraepithelial lymphocytes associated with normal villous structure is also characteristic of cow's milk sensitive enteropathy (CMSE), but no information is available about the apoptosis rate of this condition. Methods: Endoscopic biopsy samples of 21 children with untreated CMSE were compared with samples from 15 children with CD and 18 controls. Apoptosis was analyzed using the TUNEL technique and the M30 antibody from duodenal bulb and mid-duodenum samples. Ki-67 was used to detect the proliferation rate and CD3 to count the overall number of T lymphocytes. Results: In the mid-duodenum, CMSE patients showed a significantly increased intraepithelial and lamina propria density of TUNEL+ cells, but no difference in the density of M30+ epithelial cells was seen compared with controls. In CD subjects, TUNEL+ counts in mid-duodenal villous epithelium were increased. CD3+ intraepithelial lymphocytes were increased in both CMSE and CD and correlated with TUNEL+ and M30+ counts among all patients. No increase in proliferation rate was seen in CMSE, and no significant correlations between apoptosis and proliferation rates were detected. Conclusions: The observed increase in TUNEL+ counts and the absence of any increase in M30+ cells suggest that the apoptosis rate of intraepithelial lymphocytes, but not of enterocytes, is increased in the small IELs in CMSE. However, the number of intraepithelial lymphocytes is still elevated in CMSE, indicating that a disturbance of homeostasis of intraepithelial lymphocytes is important in its pathogenesis.
Transcription Factor B Contacts Promoter DNA Near the Transcription Start Site of the Archaeal Transcription Initiation Complex*

Transcription initiation in all three domains of life requires the assembly of large multiprotein complexes at DNA promoters before RNA polymerase (RNAP)-catalyzed transcript synthesis. Core RNAP subunits show homology among the three domains of life, and recent structural information supports this homology. General transcription factors are required for productive transcription initiation complex formation. The archaeal general transcription factors TATA-element-binding protein (TBP), which mediates promoter recognition, and transcription factor B (TFB), which mediates recruitment of RNAP, show extensive homology to eukaryal TBP and TFIIB. Crystallographic information is becoming available for fragments of transcription initiation complexes (e.g. RNAP, TBP-TFB-DNA, TBP-TFIIB-DNA), but understanding the molecular topography of complete initiation complexes still requires biochemical and biophysical characterization of protein-protein and protein-DNA interactions. In published work, systematic site-specific protein-DNA photocrosslinking has been used to define positions of RNAP subunits and general transcription factors in bacterial and eukaryal initiation complexes. In this work, we have used systematic site-specific protein-DNA photocrosslinking to define positions of RNAP subunits and general transcription factors in an archaeal initiation complex. Employing a set of 41 derivatized DNA fragments, each having a phenyl azide photoactivable crosslinking agent incorporated at a single, defined site within positions –40 to +1 of the gdh promoter of the hyperthermophilic marine archaea, Pyrococcus furiosus (Pf), we have determined the locations of PfRNAP subunits PfTBP and PfTFB relative to promoter DNA. The resulting topographical information supports the striking homology with the eukaryal initiation complex and permits one major new conclusion, which is that PfTFB interacts with promoter DNA not only in the TATA-element region but also in the transcription-bubble region, near the transcription start site. Comparison with crystallographic information implicates the PfTFB N-terminal domain in the interaction with the transcription-bubble region. The results are discussed in relation to the known effects of substitutions in the TFB and TFIIB N-terminal domains on transcription initiation and transcription start-site selection.
THE LINK BETWEEN ECO-INNOVATION AND PERFORMANCE OF CREATIVE INDUSTRY OF MARBLE AND NATURAL STONE CRAFT

This study investigates the effect of eco-innovation on creative industry production performance of marble and natural stone craft sector in Tulungagung, Indonesia. Mostly, the companies are in form of small and medium-sized enterprises (SMEs) which is ‘passive eco-innovator’ and their eco-innovation variables have not been investigated before in terms of their influence on their performance. The respondents were 81 craftsmen taken from the population. The data were collected through questionnaires which were tested, processed and analyzed by using consistent Partial Least Squares – Structural Equation Modeling (PLSc-SEM). From this study, it can be concluded that in creative industries center of marble and natural stone crafts in Tulungagung, eco-marketing innovation significantly influence on eco-process innovation, but not significantly influence on eco-product innovation. Implementation of eco-process innovation significantly influence on eco-product innovation. Eco-product innovation significantly influence on production performance but not significantly influence on market performance. Production performance significantly influence financial performance.
IMPAIRMENT OF QUALITY OF LIFE AMONG ADULTS WITH SKIN DISEASE IN KING FAHAD MEDICAL CITY, SAUDI ARABIA

Objectives: The objective of the study was to assess the quality of life in patients with skin disease. Subjects and Methods: A 6-month cross-sectional study was conducted in the Dermatology Clinic at King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia. The study sample consisted of all 297 adult patients with dermatological conditions attending clinic but without associated psychiatric disease. They completed a self-administered Arabic version of the Dermatology Life Quality Index questionnaire (DLQI), containing ten items. The data was analyzed according to disease, age and gender. Results: The gender distribution of the study sample was 73% female and 27% male. The mean age was 29.4 years. The proportions of patients with various diagnoses were: sebaceous and apocrine gland disorders 31.3%, eczematous dermatitis 18.5%, cutaneous infections 13.5%, and pigmentary disorders 10.8%. The mean DLQI of all patients was 8.32. Patients with papulosquamous disorders recorded the highest mean DLQI score of 15.28, followed by immunological disorders with 11.11, eczematous dermatitis with 9.55, and miscellaneous disorders with 10.91. The mean DLQI was higher among females (9.02) than males (6.46). Age had no influence on the degree of impairment. Conclusion: Measuring the impairment of the quality of life in dermatology patients is an important aspect of management. It allows clinicians to assess the extent and nature of the disability so that an appropriate management regimen can be implemented and its effectiveness assessed.
Equilibrium Conditions in Laser-Desorbed Plumes: Thermodynamic Properties of α-Cyano-4-Hydroxycinnamic Acid and Protonation of Amino Acids

The equilibrium nature of a plume of laser desorbed material is explored through the application of a simple equilibrium model to the ion signals observed in 355 nm laser desorption/ionization mass spectra of mixtures of the MALDI matrix α-cyano-4-hydroxycinnamic acid (αCHCA) with the amino acids glycine, alanine, valine, isoleucine, and phenylalanine. In these studies it is found that there are systematic and predictable increases in the relative yield of protonated amino acid with increases in amino acid gas-phase basicity. In addition, the thermodynamic values extracted from the equilibrium plot are shown to be in good agreement with values obtained from computational investigation of plausible αCHCA proton donor species. These results are supportive of a picture wherein the laser-desorbed material is viewed as a dense plume in which facile charge transfer occurs leading, ultimately, to a thermodynamically equilibrated distribution of proton donor and proton acceptor species.
Inspections in a data-driven world: Utilizing multiple sources of knowledge to achieve risk-based regulation

The last decades, the role of data in society has increased rapidly. The Dutch regulation agencies have to embrace this age of digitization. It provides challenges, as the inspection work becomes more complex. It also provides opportunities, because data analysis could make the inspections more efficient. One of these inspection agencies is the NVWA, the Netherlands Food and Safety Authority. The NVWA strives to work risk-oriented, and expects data analysis to be an important tool to achieve this goal. However, most inspectors have little knowledge on data analysis. Thus, a new type of employee needs to be contracted: the data analyst. The NVWA wants the data analysts and inspectors to work together and share their knowledge. Together, they should create a risk model, which predicts where inspections should take place. These kinds of risk models are expected to change the inspection landscape. However, most of the knowledge of data analysts and inspectors is tacit, which means that their knowledge is rooted into intuition. This makes it hard to transfer to others. To solve this problem, the following research question has been used during the research: How can synergy between multiple sources of knowledge be created and utilized to achieve risk based regulation?
A Pluggable Large Core Step Index Plastic Optical Fiber With Built-In Mode Conditioners for Gigabit Ultra Short Reach Networks

Large core step-index plastic optical fibers (SI-POF) are bandwidth limited due to their high modal dispersion and coupling loss at the receiver. To date, the large core SI-POF are typically deployed up to 150 Mb/s applications. This paper reports the transmission of 2.5 Gb/s on 980 μm core step-index plastic optical fiber with fiber-based mode conditioning elements that are part of the connector assembly. The built-in mode conditioners are tapered fiber tips that provide restricted mode launching at transmitter and mode filtering at the receiver side. The structures, at the tip of POF, are optimized by optical simulations and fabricated using laser fusion process. The connector assembly is realized by precisely encapsulating the mode conditioners with a metallic ferrule and positioned using optical grade epoxies. These plug-in modules are inserted to a typical SFP transceiver LC connector receptacle and characterized for gigabit rates.
Firm Size Distributions and Cross-Country Labor Market Outcomes

It is well-known that developing countries have many fewer large firms and that this has important implications for productivity. In this paper we collect and harmonize labor force surveys from 17 countries at different stages of development to document complementary facts about how the firm size distribution affects labor markets. Workers at large firms earn higher wages, have longer tenures, and enjoy more persistent employment in all countries. The firm size distribution accounts for a moderate fraction of cross-country variation in wages, tenure, and labor market churn. Viewed through the lens of a model of labor market churn, these facts jointly suggest that large firms provide better matches and that poor country labor markets suffer as a result of the missing large firms.
Purification and Characterization of the 20S Proteasome from Ostrich Skeletal Muscle

Abstract The proteasome is a high molecular weight, multisubunit and multicatalytic enzyme. Here we report the purification and characterization of ostrich skeletal muscle 20S proteasome. It was purified to homogeneity with Mr 700 000, pI 6.67 and a ladder of 22.2 33.5 kDa bands on SDSPAGE. The amino acid composition and aminoterminal sequences showed large identities to those of other species. For the three major activities, pH and temperature optima ranged between 8.0 11.0 and 40 70C, and stabilities between 5 12 and up to 40 60C. Substrate specificity and inhibitory effects were also studied. Many similarities to other sources were shown, with a few significant differences.
1-Bit Compressive Sensing via Approximate Message Passing with Built-in Parameter Estimation

1-bit compressive sensing aims to recover sparse signals from quantized 1-bit measurements. Designing efficient approaches that could handle noisy 1-bit measurements is important in a variety of applications. In this paper we use the approximate message passing (AMP) to achieve this goal due to its high computational efficiency and state-of-the-art performance. In AMP the signal of interest is assumed to follow some prior distribution, and its posterior distribution can be computed and used to recover the signal. In practice, the parameters of the prior distributions are often unknown and need to be estimated. Previous works tried to find the parameters that maximize either the measurement likelihood or the Bethe free entropy, which becomes increasingly difficult to solve in the case of complicated probability models. Here we propose to treat the parameters as unknown variables and compute their posteriors via AMP as well, so that the parameters and the signal can be recovered jointly. This leads to a much simpler way to perform parameter estimation compared to previous methods and enables us to work with noisy 1-bit measurements. We further extend the proposed approach to the general quantization noise model that outputs multi-bit measurements. Experimental results show that the proposed approach generally perform much better than the other state-of-the-art methods in the zero-noise and moderate-noise regimes, and outperforms them in most of the cases in the high-noise regime.
Node importance measure for scientific research collaboration from hypernetwork perspective

Original scientific paper Collaboration has become main stream and trend in interdisciplinary fields. In research collaboration organizations, to evaluate the contributions of researchers to the organization and then to identify core researchers is an important issue to carry out performance appraisal and crisis management of brain drain. Scientific research collaboration network is a basic model to investigate this question, but under the context of increasingly complex collaborative behaviour, it shows its limitations for semantic representations. In this paper, by introducing hypernetwork, a more powerful modelling tool than traditional network, and taking scientific paper co-authorship as object to construct scientific research collaboration hypernetwork (SRCH), we measure the importance of researchers in two aspects, as collaborative relationship structure and collaborative achievement value from a hypernetwork perspective. An additive weighting method with adjustable parameters is utilized to integrate the evaluation indicators of the two aspects, and then the synthetical importance evaluation of researchers is obtained. Analysis of data instance verifies that our node importance measure for scientific research collaboration from hypernetwork perspective is reasonable and effective.
A feedback linearization based Wind turbine control system for ancillary services and standard steady state operation

In this paper the control problem of the wind turbine driven doubly fed induction generator (DFIG) is faced, both in wind park operator and system operator perspective. Two control schemes are proposed, based on feedback linearization theory for MIMO systems and PI controllers: the first one for simultaneous active and reactive power regulation, the second one for simultaneous propeller angular speed and reactive power regulation. They are shown to allow the deliver of ancillary services to the system operator and the maximization of wind park operator profitability respectively.
Bone marrow VEGFC expression is associated with multilineage dysplasia and several prognostic markers in adult acute myeloid leukemia, but not with survival

Abstract Vascular endothelial growth factor C (VEGFC) stimulates leukemia cell proliferation and survival, and promotes angiogenesis. We studied VEGFC expression in bone marrow samples from 353 adult acute myeloid leukemia (AML) patients and its relationship with several clinical, cytogenetic, and molecular variables. We also studied the expression of 84 genes involved in VEGF signaling in 24 patients. We found that VEGFC expression was higher in AML patients with myelodysplasia-related changes (AML-MRC) than in patients with non-AML-MRC. We also found an association between VEGFC expression and the patient cytogenetic risk group, with those with a worse prognosis having higher VEGFC expression levels. No correlation was observed between VEGFC expression and survival or complete remission. VEGFC expression strongly correlated with expression of the VEGF receptors FLT1, KDR, and NRP1. Thus, in this series, VEGFC expression was increased in AML-MRC and in subgroups with a poorer prognosis, but has no impact on survival.
Escherichia coli PriA protein is essential for inducible and constitutive stable DNA replication.

Under certain conditions, Escherichia coli cells exhibit either of two altered modes of chromosomal DNA replication. These are inducible stable DNA replication (iSDR), seen in SOS‐induced cells, and constitutive stable DNA replication (cSDR), seen in rnhA mutants. Both iSDR and cSDR can continue to occur in the absence of protein synthesis. They are dependent on RecA protein, but do not require DnaA protein or the oriC site. Here we report the requirement for PriA, a protein essential for assembly of the phi X174‐type primosome, for both iSDR and cSDR. In priA1(Null)::kan mutant cells, iSDR is not observed after induction by thymine starvation. Replication from one of the origins (oriM1) specific to iSDR is greatly reduced by the priA1::kan mutation. cSDR in rnhA224 mutant cells deficient in RNase HI is also completely abolished by the same priA mutation. In both cases, SDR is restored by introduction of a plasmid carrying a wild‐type priA gene. Furthermore, the viability of an rnhA::cat dnaA46 strain is lost at 42 degrees C upon inactivation of the priA gene, indicating the lethal effect of priA inactivation on those cells whose viability depends on cSDR. These results demonstrate that a function of PriA protein is essential for iSDR and cSDR and suggest the involvement of the PriA‐dependent phi X174‐type primosome in these DnaA/oriC‐independent pathways of chromosome replication. Whereas ColE1‐type plasmids, known to be independent of DnaA, absolutely require PriA function for replication, DnaA‐dependent plasmid replicons such as pSC101, F, R6K, Rts1 and RK2 are able to transform and to be maintained in the priA1::kan strain. (ABSTRACT TRUNCATED AT 250 WORDS)
Evaluation of enzyme immunoassay for hepatitis B virus DNA based on anti-double-stranded DNA

We have evaluated a new enzyme immunoassay technology to detect the products of PCR-based amplification that may be applicable to routine testing of hepatitis B virus (HBV) DNA. Two hundred eight serum samples were studied: 73 were basal samples and 135 were sequential serum samples from patients with chronic hepatitis, some of whom were being treated with alpha interferon. We compared the new detection method (PCR-DNA enzyme immunoassay [DEIA]) with dot blot hybridization performed without prior PCR amplification and with two other methods for detection of PCR products: agarose gel electrophoresis with ethidium bromide staining (PCR-EB) and dot blot (PCR-dot blot). For hepatitis B-antigen-positive basal samples, HBV DNA was detected in 70.4% by dot blot, 74.1% by PCR-EB, and 100% by PCR-DEIA and PCR-dot blot; for anti-hepatitis B e-antigen basal samples, HBV DNA was found in 10.5% by dot blot and PCR-EB and in 42.1% by PCR-DEIA and PCR-dot blot. Chi-square tests showed a strong association between dot blot and PCR-EB and between PCR-DEIA and PCR dot blot. Using PCR-dot blot as the reference, dot blot shows a 56.9% sensitivity and a 100% specificity, PCR-EB shows a 55.0% sensitivity and a 100% specificity, and PCR-DEIA shows a 95.4% sensitivity and a 97% specificity. We conclude that the technical advantages of the DEIA method and its high sensitivity and specificity may facilitate the use of PCR in routine testing for HBV DNA in clinical microbiology laboratories.