Miracle-dz/UniFAR-FTUs huggingface dataset:
Traditional Marketing Practice Model and Entrepreneurship Marketing in SMEs in Indonesia

Small Medium Enterprises (SMEs) in Indonesia have a significantly strategic role in the national economy to improve employment, Gross Domestic Product (GDP) and export value, thus increase the economic growth in Indonesia. The purpose of the study is to describe and analyze the traditional marketing practices and entrepreneurial marketing and their effects on business performance. The object of the research is industrial SMEs in garment production, located in East Java Province. The number of research samples is 134. The data is analyzed by using SEM-PLS and Different Test Statistics. The result of the study indicates that the traditional marketing practice model and entrepreneurial marketing influence business performance. And the other research results show that there are differences in traditional marketing practices and entrepreneurial marketing in SMEs. The concept of entrepreneurial marketing is suitable for SMEs to improve their business performance. From the research it is recommended that the government policy, with its SME empowerment program, is able to overcome marketing challenges. For SMEs, they need to consider and learn the entrepreneurial marketing concept as a new paradigm in marketing.
GABAB receptor‐mediated modulation of hypocretin/orexin neurones in mouse hypothalamus

Hypocretin/orexin (Hcrt) is a critical neurotransmitter for the maintenance of wakefulness and has been implicated in several other functions, including energy metabolism and reward. Using whole‐cell patch‐clamp recordings from transgenic mice in which enhanced green fluorescent protein was linked to the Hcrt promoter, we investigated GABAergic control of the Hcrt neurones in hypothalamic slices. Bath application of GABA or muscimol caused an early hyperpolarization mediated by Cl− and a late depolarization mediated by the efflux of bicarbonate. These GABAA receptor‐mediated responses were blocked by picrotoxin and bicuculline. Under the GABAA blockade condition, GABA produced consistent hyperpolarization, decreased firing rate and input resistance. The selective GABAB agonist (R)‐baclofen caused a similar response with an EC50 of 7.1 μm. The effects of (R)‐baclofen were blocked by the GABAB antagonist CGP 52432 but persisted in the presence of tetrodotoxin, suggesting direct postsynaptic effects. The existence of GABAB modulation was supported by GABAB(1) subunit immunoreactivity on Hcrt cells colabelled with antisera to the Hcrt‐2 peptide. Furthermore, GABAB receptor activation inhibited the presynaptic release of both glutamate and GABA. (R)‐Baclofen depressed the amplitude of evoked excitatory postsynaptic currents (EPSCs) and inhibitory synaptic currents (IPSCs), and also decreased the frequency of both spontaneous and miniature EPSCs and IPSCs with a modest effect on their amplitudes. These data suggest that GABAB receptors modulate Hcrt neuronal activity via both pre‐ and postsynaptic mechanisms, which may underlie the promotion of non‐rapid eye movement sleep and have implications for the use of GABAB agonists in the treatment of substance addiction through direct interaction with the Hcrt system.
Changes in Brain Electrical Activity After Cognitive Behavioral Therapy for Posttraumatic Stress Disorder in Patients Injured in Motor Vehicle Accidents

Objective: To explore changes for the first time in neural processing due to effective cognitive behavioral therapy (CBT) in posttraumatic stress disorder (PTSD) after severe motor vehicle accidents. Recent studies have highlighted the role of right hemisphere activation during withdrawal-related emotions (e.g., anxiety). There has been little research on changes in brain function due to cognitive-behavioral interventions in anxiety disorders. Methods: We conducted a randomized, controlled trial comparing cognitive-behavioral therapy with an assessment-only Wait-list condition. Spontaneous electroencephalographic activity was recorded from left and right anterior and posterior regions in participants with PTSD/subsyndromal PTSD receiving CBT (n = 17) before and after a CBT program. Wait-list controls (n = 18) were investigated before and after 3 months. Results: At the pretreatment assessment, a pattern of increased right-sided activation during exposure to a trauma-related picture (relative to a neutral picture) was observed in both CBT and Wait-list participants. At posttreatment, there was a greater reduction of right anterior activation in the CBT group as compared with Wait-list controls. Across both groups, PTSD symptom reduction was significantly positively correlated with a decrease in right anterior activation to the trauma stimulus. Conclusions: These findings suggest that effective CBT treatment of PTSD may be accompanied by adaptive changes in asymmetrical brain function. Future studies are needed to confirm our findings. CBT = cognitive behavioral therapy; PTSD = posttraumatic stress disorder; EEG = electroencephalography; MDD = major depression; CAPS = Clinician Administered PTSD Scale; PANAS = Positive and Negative Affective Scale; MANOVA = multivariate analysis of variance.
Improvement of muscle strength and fatigue with high voltage pulsed galvanic stimulation in multiple sclerosis patients--a non-randomized controlled trial.

OBJECTIVE To examine the effects of High Voltage Pulsed Galvanic Stimulation (HVPGS), that was applied to the spasticity associated weakness in knee flexors and ankle dorsiflexors, on strength and fatigue, in Multiple Sclerosis (MS) patients, in a non-randomized controlled trial. METHODS A total of 33 MS patients were included. Fatigue and strength were analyzed with 3rd and 30th second data by dynamometric measurements synchronously with surface electromyography (EMG) [power spectrum analysis (amplitude, mean frequency, median frequency and root means square]. In the experimental group HVPGS and in the control group repetitive contractions from Proprioceptive Neuromuscular Facilitation (PNF) technique were applied for 18 treatment sessions. RESULTS In both groups and all muscle groups, dynamometric measurement and EMG results in the 30th second were significantly lower according to in the 3rd second before and after the treatments. Both strength and fatigue improved after the treatment both in the HVPGS and PNF group. CONCLUSION It was concluded that, MS patients have both central and peripheral fatigue. FO2 localized and intensive effects in strength and fatigue, HVPGS was more impressive than the PNF. PNF was more effective to obtain general effects. Moreover, the application of HVPGS with other rehabilitation techniques may be more appropriate and effective.
Politicizing European Integration. Struggling with the Awakening Giant

The systematic examination of the politicization of European integration in six Western European countries constitutes an impressive contribution of this book. The book also presents an imposing long-term quantitative-qualitative research method and it offers a number of theoretical propositions which could be extended to the study of politicization across Europe, in spite of the limitation of the study to selected Western European countries.
Controversies in the management of aneurysmal subarachnoid hemorrhage*

Background:The care of patients with aneurysmal subarachnoid hemorrhage has evolved significantly with the advent of new diagnostic and therapeutic modalities. Although it is believed that these advances have contributed to improved outcomes, considerable uncertainty persists regarding key areas of management. Objective:To review selected controversies in the management of aneurysmal subarachnoid hemorrhage, with a special emphasis on endovascular vs. surgical techniques for securing aneurysms, the diagnosis and therapy of cerebral vasospasm, neuroprotection, antithrombotic and anticonvulsant agents, cerebral salt wasting, and myocardial dysfunction, and to suggest venues for further clinical investigation. Data Source:Search of MEDLINE and Cochrane databases and manual review of article bibliographies. Data Synthesis and Conclusions:Many aspects of care in patients with aneurysmal subarachnoid hemorrhage remain highly controversial and warrant further resolution with hypothesis-driven clinical or translational research. It is anticipated that the rigorous evaluation and implementation of such data will provide a basis for improvements in short- and long-term outcomes.
Structural consequences of endosteal metastatic lesions in long bones

Lytic metastatic lesions from breast, prostate, and other cancers often develop on the endosteal surface of a long bone without penetrating the cortical wall. Current clinical guidelines for determining the fracture risk associated with these endosteal defects do not account for the structural consequences of the lesion. We undertook a combined experimental and analytical study of the structural consequences of the lesions with the ultimate goal of providing improved fracture risk guidelines. Endosteal defects of variable length and involving a variable amount of the cortical wall were created with an expanding reamer in canine femurs. The contralateral femur served as a control. The femurs were tested to failure in four point bending. The geometry of the experimental defects was determined from radiographs and CT. Finite element models of the canine femurs were then used to examine geometric and material parameters in both four point bending and in torsion. The experimental data demonstrate a linear relation between bone strength and amount of cortical wall remaining: % intact strength = 99.6 × remaining wall thickness −2.0, R2 = 0.769, standard deviation of regression = 11.57. Four of five data points from the linear finite element models were within the 95% confidence intervals for the experimental data. Experimental and finite element data suggest that the minimum wall thickness is the most critical geometric parameter for predicting the structural consequences of endosteal defects. The length of the defect along the bones' long axis has little effect on bone strength. The length of the defect along the bones' long axis has little effect on bone strength. The anelastic behavior of bone does not need to be represented in finite element models of simple endosteal defects because the defects do not cause significant stress concentrations. However, reduction in the modulus of bone along the border of a defect (due to osteolytic changes) can significantly reduce bone strength. These results indicate that the minimum wall thickness should be determined when clinically evaluating an endosteal defect. The results also suggest that information on bone porosity around metastatic lesions should be considered when making estimates of bone strength.
The Joint Distribution of Income and Wealth in Uruguay

This paper analyzes the joint distribution of income and wealth in Uruguay, and compares it to that of Chile, Spain and the U.S. using data from Surveys of Household Finances and Wealth. First, we analyze income and wealth separately and find that wealth is much more concentrated and notably more asymmetric than income. Afterwards, we provide non-parametric estimation of copulas for income and wealth. As expected, high income households are among the wealthiest, while low income households are mostly in the bottom of the wealth distribution, but dependence at the top is much stronger. Although this fact is observed in all the economies analyzed, by performing a test of equality between copulas we find that the pattern of dependence significantly varies across countries, except for the couple of Spain-Uruguay. Finally, we assess for the sources of income and wealth heterogeneity in Uruguay and conclude that education strongly influences income, wealth and the relationship between them. However, most of the wealth heterogeneity and some remarkable features of its relationship with income (in particular the peak at the top of the joint distribution) are not explained by the household characteristics commonly used to study income.
Spatiotemporal localization of the calcium‐stimulated adenylate cyclases, AC1 and AC8, during mouse brain development

Type 1 and type 8 adenylate cyclases, AC1 and AC8, are membrane bound enzymes that produce cAMP in response to calcium entry and could thus control a large number of developmental processes. We provide a detailed spatiotemporal localization of these genes in the mouse brain during embryonic and postnatal life using in situ hybridization. AC1 gene expression begins early in embryonic life (before E13), and its expression is much more widespread than in adults. Transient expression of AC1 is found in the striatum, the dorsal thalamus, the trigeminal nerve nuclei, the Purkinje cells of the cerebellum, the interneurons of the hippocampus, and the retinal ganglion cells. In all these structures, the peak of AC1 gene expression occurs during early postnatal life, decreasing by P10. After P15, AC1 expression is confined to the hippocampus, the cerebral cortex, and to the granule cells of the cerebellum. AC8 gene expression also begins early in embryonic life (E12)—but in a more limited number of regions than in adults. AC8 expression is initially restricted to the epithalamus, the hypothalamus, the superior colliculus, the cerebellar anlage the proliferative zone of the rhombic lip, and the spinal cord. The expression increases and broadens during postnatal life, particularly in the thalamus and the cerebral cortex. A transient peak of AC8 expression is found in layer IV of the somatosensory cortex. Thus, AC1 and AC8 have an early developmental onset with complementary spatiotemporal distribution patterns: AC1 is most broadly distributed in embryonic life, whereas AC8 is most broadly expressed in adulthood. Transient expression of these genes designate areas that may be particularly sensitive to neural activity/calcium‐modulated cAMP responses during development. J. Comp. Neurol. 486:281–294, 2005. © 2005 Wiley‐Liss, Inc.
Identifying the mechanism of Escherichia coli O157:H7 survival by the addition of salt in the treatment with organic acids

In this study, the effects of the addition of salt to treatment with acids (one of several organic acids and salt in various solutions including rich or minimal broth, buffer, or distilled water) on the reduction of Escherichia coli O157:H7 were investigated. The protein expression profiles corresponding to acid stress (acetic acid) with or without salt addition were studied using a comparative proteomic analysis of E. coli O157:H7.
Genetic Characterization and Assessment of Authenticity of Ancient Korean Skeletal Remains

Abstract To study the maternal lineage history of Korea, we extracted DNA from the skeletal remains of 35 museum samples (some dating back to the Paleolithic Age) excavated from 11 local burial sites scattered throughout southern Korea. Mitochondrial DNA (mtDNA) control region sequences (HV1, HV2, and HV3) were successfully determined for 11 samples with no sharing of the control region polymorphisms with individuals involved in the laboratory analyses. Each of the 11 mtDNAs was assigned to the appropriate East Asian mtDNA haplogroup according to the haplogroup-specific control region mutation motif and diagnostic coding region single nucleotide polymorphism. The successful mtDNA haplogroup determination for each ancient Korean mtDNA and the confirmation of the absence of abnormal mutations based on the haplogroup-directed database comparisons indicates that there is no mosaic structure from cross-contamination or sample mix-up or other errors in our mtDNA sequences. The presence of haplogroups B, D, and G in the prehistoric age is consistent with the hypothesis that the early Korean population has a common origin in the northern regions of the Altai Mountains and Lake Baikal of southeastern Siberia. In addition, the modern Korean population, which possesses lineages from both southern and northern haplogroups, suggests additional gene flow from southern Asian haplogroups in recent times, but many more ancient samples need to be analyzed to directly tell whether there was regional continuity or replacement of early lineages by other lineages in ancient Korea.
A bootstrap test to detect prominent Granger-causalities across frequencies

Granger-causality in the frequency domain is an emerging tool to analyze the causal relationship between two time series. We propose a bootstrap test on unconditional and conditional Granger-causality spectra, as well as on their difference, to catch particularly prominent causality cycles in relative terms. In particular, we consider a stochastic process derived applying independently the stationary bootstrap to the original series. Our null hypothesis is that each causality or causality difference is equal to the median across frequencies computed on that process. In this way, we are able to disambiguate causalities which depart significantly from the median one obtained ignoring the causality structure. Our test shows power one as the process tends to non-stationarity, thus being more conservative than parametric alternatives. As an example, we infer about the relationship between money stock and GDP in the Euro Area via our approach, considering inflation, unemployment and interest rates as conditioning variables. We point out that during the period 1999-2017 the money stock aggregate M1 had a significant impact on economic output at all frequencies, while the opposite relationship is significant only at high frequencies.
Research and Application of Auto-Scaling Unified Communication Server Based on Docker

With the continuous development of communication technology, Unified Communication (UC) has also attracted much attention. At present, most of the Unified Communication servers are deployed on virtual machines, but virtual machines have the characteristics of large resource occupation, slow startup speed, poor flexibility and low efficiency, which brings some problems. In contrast, container technology is characterized by run-time lightweight and application deployment fast, combined with the characteristics of the container, this paper presents a design of auto-scaling Unified Communication servers based on Docker. This paper uses Kubernetes as a choreographer. As the current Kubernetes auto-scaling algorithm is poor flexible, we propose an auto-scaling mechanism. It combines the responsive scaling with the predictive scaling, the reliability of the system is ensured, greatly improves the flexibility of Unified Communication deployment, speeds up the introduction of new business speed, and has very strong elastic expansion capacity.
Tuberculous Pericarditis

Background— The incidence of tuberculous pericarditis is increasing in Africa as a result of the human immunodeficiency virus (HIV) epidemic. The primary objective of this article was to review and summarize the literature on the pathogenesis, diagnosis, and management of tuberculous pericarditis. Methods and Results— We searched MEDLINE (January 1966 to May 2005) and the Cochrane Library (Issue 1, 2005) for information on relevant references. A “definite” diagnosis of tuberculous pericarditis is based on the demonstration of tubercle bacilli in pericardial fluid or on a histological section of the pericardium; “probable” tuberculous pericarditis is based on the proof of tuberculosis elsewhere in a patient with otherwise unexplained pericarditis, a lymphocytic pericardial exudate with elevated adenosine deaminase levels, and/or appropriate response to a trial of antituberculosis chemotherapy. Treatment consists of the standard 4-drug antituberculosis regimen for 6 months. It is uncertain whether adjunctive corticosteroids are effective in reducing mortality or progression to constriction. Surgical resection of the pericardium remains the appropriate treatment for constrictive pericarditis. The timing of surgical intervention is controversial, but many experts recommend a trial of medical therapy for noncalcific pericardial constriction, and pericardiectomy in nonresponders after 4 to 8 weeks of antituberculosis chemotherapy. Conclusions— Research is needed to improve the diagnosis, assess the effectiveness of adjunctive steroids, and determine the impact of HIV infection on the outcome of tuberculous pericarditis.
The Listeria Protein Internalin B Mimics Hepatocyte Growth Factor‐Induced Receptor Trafficking

Increased hepatocyte growth factor receptor (HGFR) signaling correlates closely with neoplastic invasion and metastatic potential of many human cancers. Hepatocyte growth factor receptor signaling is initiated by binding the physiological ligand HGF or the internalin B (InlB) protein of Listeria monocytogenes. Subsequent degradation of endocytosed HGFR terminates receptor signaling. Previously reported discrepancies in InlB and HGF‐induced HGFR signaling could reflect differences in receptor internalization and degradation in response to these distinct ligands. We report that soluble InlB and HGF are mechanistically equivalent in triggering clathrin‐dependent endocytosis and lysosomal degradation of HGFR. After internalization, InlB and HGF colocalize with Rab5, EEA1 and the transferrin receptor in classical early endosomes. Hepatocyte growth factor receptor internalization was prevented by overexpression of dominant negative mutants of dynamin 1 and epidermal growth factor phosphorylation substrate 15, but not caveolin 1, the GTPase Arf6 or the cholesterol‐chelating drug Nystatin. Thus, HGFR internalization is principally clathrin‐mediated and is not regulated by clathrin‐ independent pathways. Phosphatidylinositol 3‐kinase signaling and HGF‐regulated tyrosine kinase substrate were not required for ligand‐triggered internalization of HGFR but were essential for subsequent lysosomal degradation. Thus, soluble InlB and HGF induce HGFR endocytosis and degradation by indistinguishable mechanisms, suggesting that InlB may be exploited to regulate pathogenic HGFR signaling.
Immunofluorometric activity-based probe analysis of active KLK6 in biological fluids

Abstract Immunoassay measurements of human kallikrein-related peptidases (KLKs) such as prostate-specific antigen (KLK3) are of great value as diagnostic indices of cancer. Despite extensive knowledge of the abundance of immunoreactive KLKs in normal and cancer-related settings, there is little information available about the proportion of immunoreactive KLK that represents active enzyme in such samples. Using KLK6 as a prototype enzyme, we have developed an assay using a serine proteinase-targeted activity-based probe coupled to antibody capture. By employing activity-based labeling, we were able to quantify the proportion of enzymatically active relative to total immunoreactive KLK6 in crude cerebrospinal fluid from routine analyses and ascites fluid from ovarian cancer patients, as well as in supernatants from cancer cell lines. Our approach allowed monitoring of pro-KLK6 conversion to its active enzyme species and demonstrated that up to 5% of immunoreactive KLK6 detected in clinical samples represents active enzyme. We suggest that this new activity-based probe assay will prove of value as a complement to routine KLK immunoassay measurements for validating KLKs as cancer biomarkers.