Miracle-dz/UniFAR-FTUs huggingface dataset:
Improvement in the gastrointestinal absorption of troglitazone when taken with, or shortly after, food.

AIMS Troglitazone, an insulin action enhancing agent, is currently in clinical development for the treatment of non insulin dependent diabetes mellitus. The objective of this study was to establish the effect of food on the systemic absorption and metabolism of troglitazone. METHODS After an overnight fast, 12 healthy male volunteers each received, in random order, troglitazone (400 mg orally) alone, concomitantly with (at the start of), and 30 min after, a standardized diabetic breakfast as part of a three-period crossover study. RESULTS When troglitazone was administered with or after food, geometric mean values of area under the plasma concentration-time curves (AUC[last]) relative to fasting state were increased significantly by 59% in both cases (95% CI 1-150%, P=0.046 and 2-148%, P=0.040) with values of 11.4, 11.5 and 7.2 microg ml(-1) h respectively. Maximum observed plasma concentration (Cmax) increased by 96% and 72% (95% CI 29-197%, P=0.003 and 15-158%, P=0.011) with values of 2.2, 2.0 and 1.1 microg ml(-1) respectively. Changes in t(lag) were not clinically significant. Increases in AUC(0, infinity) for the main circulating sulphate metabolite relative to fasting were also significant (41%, 95% CI 5-89%, P=0.025 and 34%, 95% CI 1-79%, P= 0.044 respectively) with values of 82.6, 78.6 and 58.5 microg h ml(-1). Cmax increased by 68% (95%, CI 10-156%, P=0.019) and 65% (95% CI 9-149%, P=0.020) with values of 3.2, 3.1 and 1.9 microg ml(-1) respectively. Reductions in t1/2 (16 and 21%, 95% CI 0-30, 6-33) although statistically significant (P=0.050 and P=0.009) were not clinically significant with values of 22.3, 20.4 and 24.5 h for with food, after food and fasting respectively. Troglitazone was well tolerated in all cases throughout the study with a trend for improved tolerability of gastrointestinal symptoms when taken 30 min after a meal. CONCLUSIONS The absorption of troglitazone is enhanced significantly by food with little effect on the main metabolic pathway. Increased absorption of troglitazone in the presence of food is likely to be a consequence of enhanced solubility in bile combined with an increase in dissolution time. On the basis of these findings, troglitazone should be taken either with, or up to 30 min after, food.
Antihypertensive effect of Iranian Crataegus curvisepala Lind.: a randomized, double-blind study.

The aim of the present study was to investigate the potential antihypertensive effects of extracts of the flavonoid-rich Iranian flower, Crataegus curvisepala Lind. , a member of the Rosaceae family. The hydroalcoholic extract of the leaves and flowers were studied in a double-blind, placebo-controlled clinical trial to determine its effects. A total of 92 men and women with primary mild hypertension, aged 40-60 years, were selected and divided randomly into two groups, receiving either hydroalcoholic extract of C. curvisepala Lind. or placebo three times daily for more than 4 months. Blood pressure (BP) was measured each month. Statistical analysis was carried out using Student's t-test. The results obtained showed a significant decrease in both systolic and diastolic BP after 3 months (p < 0.05). C. curvisepala has a time-dependent antihypertensive effect.
Showrooming: the effect of gender

ABSTRACT Showrooming, or shopping in bricks-and-mortar stores and receiving their services without payment, but purchasing from a lower-priced online retailer, can be detrimental to the survival of bricks-and-mortar stores. This study examines how the gender of young adult consumers with differing shopping orientations view showrooming. The results suggest that showrooming is not just a male or a female phenomenon among young adults. The findings suggest, however, that bricks-and-mortar retailers may possibly be better able to dissuade female consumers from engaging in some showrooming activity more easily than males. On the other hand, online retailers may find it easier to prompt male consumers into showrooming activity than females. Although shopping orientations have been shown to affect individuals’ propensities to engage in showrooming activity and the perceived ethicality of doing so, there appears to be no difference by gender. The results suggest that gender has relatively little effect in consumers’ showrooming activity.
Long head of biceps brachii tendon evaluation: accuracy of preoperative ultrasound.

OBJECTIVE The purpose of this study was to investigate the ability of ultrasound to accurately identify long head of biceps brachii (LHB) tendon abnormalities. MATERIALS AND METHODS The surgical findings for 66 consecutive patients who underwent arthroscopic shoulder surgery were retrospectively compared with the findings of preoperative ultrasound examination. Patients were excluded if more than 200 days elapsed between ultrasound and surgery. Ultrasound images were obtained using high-frequency transducers and were compared with findings at arthroscopy for the presence of LHB tendon abnormalities, including full-thickness tears, partial-thickness tears, or nontear abnormalities, including tendinosis and tenosynovitis. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated for full- and partial-thickness tears. RESULTS Ultrasound correctly identified 90% (35/39) of normal LHB tendons, 88% (7/8) of full-thickness tears, 27% (3/11) of partial-thickness tears, and 22% (2/9) of tendons with nontear abnormality in those patients who underwent surgery. In the ultrasound diagnosis of full-thickness tear versus other findings, sensitivity was 0.88, specificity was 0.98, PPV was 0.88, NPV was 0.98, and accuracy was 0.97; in the ultrasound diagnosis of partial-thickness tear versus other findings, sensitivity was 0.27, specificity was 1.00, PPV was 1.00, NPV was 0.88, and accuracy was 0.88, in those patients who underwent surgery. CONCLUSION Shoulder ultrasound is an accurate method to confirm a normal biceps tendon or full-thickness tear, but is less accurate in the diagnosis of partial-thickness tear and nontear abnormalities.
Examining success of communication strategies used by formal caregivers assisting individuals with Alzheimer's disease during an activity of daily living.

PURPOSE To examine how formal (i.e., employed) caregivers' use verbal and nonverbal communication strategies while assisting individuals with moderate to severe Alzheimer's disease (AD) during the successful completion of an activity of daily living (ADL). Based on the literature, the authors hypothesized that caregivers' use of 1 proposition, closed-ended questions, and repetition would be of most benefit. METHOD Twelve caregiver-AD dyads participated in this observational study. Each dyad was videorecorded on 6 separate occasions while completing handwashing. Handwashing sessions were transcribed and systematically coded for the use of communication strategies during completion of the ADL. RESULTS Caregiver-AD dyads successfully completed 90% of all handwashing sessions, and caregivers employed a variety of communication strategies. Consistent with our hypotheses, during successful task completion, caregivers most frequently provided individuals with AD with 1 direction or idea (i.e., proposition) at a time, closed-ended questions, and paraphrased repetition. Caregivers also frequently used encouraging comments and the resident's name during the task; however, use of these strategies was not correlated to task success rate. CONCLUSION This study adds to the limited body of evidence supporting the use of specific communication strategies by caregivers assisting individuals with moderate to severe AD during successful completion of ADLs.
Neuromorphic neural interfaces: from neurophysiological inspiration to biohybrid coupling with nervous systems

Objective. Computation in nervous systems operates with different computational primitives, and on different hardware, than traditional digital computation and is thus subjected to different constraints from its digital counterpart regarding the use of physical resources such as time, space and energy. In an effort to better understand neural computation on a physical medium with similar spatiotemporal and energetic constraints, the field of neuromorphic engineering aims to design and implement electronic systems that emulate in very large-scale integration (VLSI) hardware the organization and functions of neural systems at multiple levels of biological organization, from individual neurons up to large circuits and networks. Mixed analog/digital neuromorphic VLSI systems are compact, consume little power and operate in real time independently of the size and complexity of the model. Approach. This article highlights the current efforts to interface neuromorphic systems with neural systems at multiple levels of biological organization, from the synaptic to the system level, and discusses the prospects for future biohybrid systems with neuromorphic circuits of greater complexity. Main results. Single silicon neurons have been interfaced successfully with invertebrate and vertebrate neural networks. This approach allowed the investigation of neural properties that are inaccessible with traditional techniques while providing a realistic biological context not achievable with traditional numerical modeling methods. At the network level, populations of neurons are envisioned to communicate bidirectionally with neuromorphic processors of hundreds or thousands of silicon neurons. Recent work on brain–machine interfaces suggests that this is feasible with current neuromorphic technology. Significance. Biohybrid interfaces between biological neurons and VLSI neuromorphic systems of varying complexity have started to emerge in the literature. Primarily intended as a computational tool for investigating fundamental questions related to neural dynamics, the sophistication of current neuromorphic systems now allows direct interfaces with large neuronal networks and circuits, resulting in potentially interesting clinical applications for neuroengineering systems, neuroprosthetics and neurorehabilitation.
Ontogenic and nutritionally induced changes in fetal metabolism in the horse

1 Using the Fick principle and tracer methodology, the metabolic rates of chronically catheterized fetal foals (n= 24) were measured at different gestational ages during the second half of gestation and in response to maternal fasting for 36 h in late gestation (n= 4, term ≈ 335 days). 2 Absolute rates of umbilical blood flow, fetal glucose utilization and umbilical uptake of oxygen (O2) and glucose increased from mid‐gestation to 300 days and then plateauxed until term. The absolute rate of umbilical lactate uptake was significant after, but not before, 280 days of gestation. 3 Weight specific rates of umbilical uptake and fetal utilization of glucose decreased progressively throughout the second half of gestation. Weight specific rates of CO2 production from glucose carbon were also inversely correlated with gestational age. Umbilical lactate uptake per kilogram of fetus was lower after 320 days than between 281 and 300 days. In contrast, no gestational trends were observed in the weight specific rates of fetal O2 uptake and urea production. Glucose production by the fetal horse was negligible, even very close to term. 4 Maternal fasting for 36 h reduced the rate of umbilical uptake and utilization of glucose production but had no effect on the rates of endogenous glucose production and umbilical uptake of oxygen and lactate by the horse fetus. 5 The observations show that fetal metabolism is highly dependent on glucose in the horse compared to the sheep in mid‐ and late gestation. Different species therefore adopt different strategies in meeting the nutritional demands of the growing fetus during the second half of gestation.
Genetic Analysis of Female Preference Functions as Function‐Valued Traits

The genetic analysis of female preferences has been seen as a particularly challenging empirical endeavor because of difficulties in generating suitable preference metrics in experiments large enough to adequately characterize variation. In this article, we take an alternative approach, treating female preference as a function‐valued trait and exploiting random‐coefficient models to characterize the genetic basis of female preference without measuring preference functions in each individual. Applying this approach to Drosophila bunnanda, in which females assess males through a multivariate contact pheromone system, we gain three valuable insights into the genetic basis of female preference functions. First, most genetic variation was attributable to one eigenfunction, suggesting shared genetic control of preferences for nine male pheromones. Second, genetic variance in female preference functions was not associated with genetic variance in the pheromones, implying that genetic variation in female preference did not maintain genetic variation in male traits. Finally, breeding values for female preference functions were skewed away from the direction of selection on the male traits, suggesting directional selection on female preferences. The genetic analysis of female preference functions as function‐valued traits offers a robust statistical framework for investigations of female preference, in addition to alleviating some experimental difficulties associated with estimating variation in preference functions.
Design of an enhanced RF energy harvesting system for wireless sensors

In this paper, a technique is proposed for enhancing energy harvesting devices. The design is capable of charging small power consumption sensors by capturing ambient radio frequency (RF) waves. The technique comprises the use of high-profile monopole antenna array with a reflector in order to maximize the RF energy received by the antenna system. Furthermore, a prototype of the proposed RF energy harvesting system was built, and tested in laboratory. The proposed design is compared with a reference case that uses only a single monopole antenna element at both transmitter and receiver sides. The achieved results show better performance in terms of captured output direct current (DC) voltage in comparison to that captured energy by the reference prototype with a single antenna element. The designed system is useful in many wireless applications and can easily be integrated with other high-gain antenna systems to further maximize the harvested energy.
Comparison of diagnostic approaches, and a cost-benefi t analysis of different diagnostic approaches and treatments of anoestrous dairy cows

Abstract AIM: To compare diagnostic techniques, and to assess the economic effects of diagnosing and treating dairy cows not detected in oestrus before the planned start of mating (PSM). METHODS: Cows from 12 herds were defined as anoestrus at Day -9 (where Day 0=PSM) based on presence of tail paint that had been applied at Day -35. The presence of a corpus luteum (CL) was diagnosed by palpation or ultrasonography on Day -9, or by determining the concentration of progesterone (P4) in milk at Days -16 and -9. Cows with concentrations of P4 in milk >1 ng/ml at one or both times were defined as CL+. Cows were randomly assigned to be treated with (a) nothing (Control; n=558); (b) gonadotrophin-releasing hormone (GnRH) on Day -9, prostaglandin F2α (PGF2α) on Day -2, and GnRH on Day 0, with set-time artificial insemination (AI) 16-20 h after the second GnRH treatment (Ovsynch; n=553); or (c) as for (b) but with placement of an intravaginal P4-releasing device on Day -9, and removal on Day -2 (Ovsynch+P4; n=551). Cows detected in oestrus between Day -2 and the second GnRH treatment did not receive the second GnRH treatment. Pregnancy diagnosis took place on three occasions, and the date of conception estimated, from which the PSM-to-conception interval was calculated. Agreement between the three diagnostic techniques for CL status was evaluated using Kappa analyses, and sensitivities and specificities were calculated using a Bayesian Monte Carlo approach that does not assume a gold standard. Partial budgets and decision trees were constructed to assess the costeffectiveness of diagnosis and treatment. RESULTS: The level of agreement was higher between ultrasonography and concentration of P4 in milk (0.64) than for palpation and ultrasonography or concentration of P4 in milk (0.50 and 0.49, respectively). The Ovsynch+P4 treatment had a higher nett benefit than Ovsynch relative to no treatment (NZ$80.40 and NZ$47.50/cow treated, respectively) in the absence of diagnosis of CL status. Following diagnosis, the Ovsynch+P4 treatment remained the most cost-effective option for both CL+ and CL- cows. It was concluded that the Ovsynch+P4 treatment without any diagnostic procedure was the most cost-effective option. CLINICAL RELEVANCE: Treatment of anoestrous cows was more cost-effective than no treatment, with Ovsynch+P4 more cost-effective than Ovsynch in cows with or without a CL. Differentiation of anoestrous cows into CL+ and CL- groups for treatment was not cost-effective.
Understanding carbon trading: Effects of delegating CO2 responsibility on organizations’ trading behaviour

The establishment of a carbon market assumes that there is an effective means of transforming price information into technical carbon reduction measures. However, empirical evidence reveals that the links between price information and carbon management strategies are far from obvious. To understand how delegating CO2 responsibility affects CO2 trading behaviour, this article proposes a neo-institutionalist approach to answering the question of why companies became sellers, buyers or a combination of both during phase I of the European Emissions Trading Scheme (EU ETS). Original data from a survey on companies that participated in this scheme were collected and analysed. It was assumed that the trading scheme offered two ways to delegate decisions regarding emissions trading: decoupling from technical knowledge and financialization (i.e. delegating to financial departments) or coupling using technicalization (i.e. delegating to manufacturing departments). The results support the hypothesis that a company that adopts a decoupling strategy is more likely to buy certificates to fulfil their emissions targets. Adopting a coupling strategy indicates that a company is more likely to become a seller, all else equal. Professional identity is the theoretical basis for this relationship. Delegating carbon management to different departments represents either a stronger coupling or a stronger decoupling from core technological processes. Policy relevance The transaction data from phase I of the EU ETS open new questions and possibilities regarding the reasons that drive selling and buying in companies. It is important to look not only at the traditional sources of transaction costs, but rather also at the reasons for these tensions. One important source is the professional education of the people in charge of the EU ETS. Tailored information that directly addresses the different professional backgrounds of managers working in both financial departments and more technical departments might help to lower these types of transaction costs. In today's context, important emitter countries, such as China and Korea, have launched their own emissions markets, copying many aspects of the EU ETS. For the positive development of these markets and as a way of establishing a global emissions market, these new schemes should learn from the EU ETS experience.
Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells

Epidermal growth factor receptor (EGFR) function is transregulated by a variety of stimuli, including agonists of certain G-protein-coupled receptors (GPCRs). One of the most ubiquitous GPCRs is the P2Y1 receptor (P2RY1, hereafter referred to as P2Y1R) for extracellular nucleotides, mainly ADP. Here, we show in tumoral HeLa cells and normal FRT epithelial cells that P2Y1R broadcasts mitogenic signals by transactivating the EGFR. The pathway involves PKC, Src and cell surface metalloproteases. Stimulation of P2Y1R for as little as 15-60 minutes triggers mitogenesis, mirroring the half-life of extracellular ADP. Apyrase degradation of extracellular nucleotides and drug inhibition of P2Y1R, both reduced basal cell proliferation of HeLa and FRT cells, but not MDCK cells, which do not express P2Y1R. Thus, cell-released nucleotides constitute strong mitogenic stimuli, which act via P2Y1R. Strikingly, MDCK cells ectopically expressing P2Y1R display a highly proliferative phenotype that depends on EGFR activity associated with an increased level of EGFR, thus disclosing a novel aspect of GPCR-mediated regulation of EGFR function. These results highlight a role of P2Y1R in EGFR-dependent epithelial cell proliferation. P2Y1R could potentially mediate both trophic stimuli of basally released nucleotides and first-line mitogenic stimulation upon tissue damage. It could also contribute to carcinogenesis and serve as target for antitumor therapies.
Tweaking Black-Scholes

Option professionals routinely tweak the Black-Scholes option pricing model using a volatility smile. Using algebraic analysis and Monte Carlo simulation experiments, we compare the hedging performance of the tweaked Black-Scholes option pricing model with a stochastic volatility model in a stochastic volatility setting. We find that the tweaked Black-Scholes model almost perfectly mimics the stochastic volatility model representing the true stochastic process. This suggests why volatility smiles are widely used by options professionals to calibrate option trading and hedging strategies. These results also have implications for empirical tests of option pricing models.
Alternating information bottleneck optimization for the compression in the uplink of C-RAN

The compression step of the Cloud Radio Access Networks (C-RAN) is studied in this paper. In order to maximize the achievable sum rate in the uplink of C-RAN, constrained by the finite-capacity fronthaul links to the Central Processor (CP) in the cloud, an optimization algorithm of quantizers used for compression is proposed. In C-RAN, there are multiple Radio Units (RUs) compressing and forwarding the correlated received signals simultaneously. Due to the correlations, Wyner-Ziv coding is used. Hence a joint optimization of the quantizers is required at the CP. In this paper we extend the Information Bottleneck (IB) method for this joint optimization. It is a combination of the Alternating Information Bottleneck method (AIB) and the Alternating Bi-Section method, which are both proposed in this paper. Then we use the proposed algorithms to study some key features of C-RAN.