Miracle-dz/UniFAR-FTUs huggingface dataset:
The Drosophila KASH domain proteins Msp-300 and Klarsicht and the SUN domain protein Klaroid have no essential function during oogenesis

Proteins harboring a C-terminal KASH (Klarsicht/Anc-1/Syne Homology) domain, which attaches to the nucleus, have been identified in many different organisms. Two KASH proteins are known from Drosophila, Msp-300 and Klarsicht, the latter of which plays a role in nuclear migration during eye development. Here, we show that a complete deletion of Msp-300 leads to larval lethality. This lethality appears to be due to Msp-300 isoforms containing the N-terminal actin binding, but not the C-terminal KASH domain. Msp-300 and Klar are expressed during oogenesis and localize to the nuclear envelope of the germ line nuclei. However, neither Msp-300 single mutants nor Msp-300; klar double mutants cause defects in nuclear migration or anchoring during oogenesis. Germ line nuclear envelope localization of both KASH domain proteins depends on klaroid, the only Drosophila SUN domain homolog expressed in females. Like Msp-300 and klar, klaroid is also dispensable for normal ovarian development.
The Conundrum of Office-Based Clinical Trials

Your office manager has received a call from a contract research organization (CRO) that represents a large pharmaceutical company. They are looking for additional sites to participate in a Phase III trial of a new proton pump inhibitor which the pharmaceutical company believes has enhanced bioavailability; moreover, the half-life of the drug with this formulation is such that the drug need only be taken every 2 days and preliminary data from earlier trials suggest its efficacy in healing erosive esophagitis is at least comparable to existing agents. Potential patients must have daily heartburn when not on treatment, with endoscopic evidence of at least one erosion 2 cm in length or greater in the distal esophagus. Eligible patients would need to be off antisecretory therapy at least 2 wk prior to entry, and would undergo a baseline endoscopy (EGD [esophagogastroduodenoscopy]). Subjects would then be randomized to either drug or placebo, with follow-up EGDs in 6 and 12 wk at which point the trial would end. Procedures would be performed at your ambulatory endoscopy center (AEC). For each patient completing the study, your practice would be paid $1,500. All trial expenses would be paid, including physician and facility fees at 120% of Medicare reimbursement. The CRO would complete applications and pay expenses for review by an institutional review board (IRB) that would be conducted at an independent IRB in another state. Lastly, if 10 or more patients are successfully enrolled during the first 3 months, you will receive an additional $500 per patient.
Event-Based System Architecture in Mobile Ad Hoc Networks (MANETs)

The publish/subscribe paradigm (Muhl, Fiege, & Pietzuch, 2006) communicates on the basis of either the message content or the message source being of interest to destinations – as opposed to the source specifying the recipient(s). P/S systems can be considered to be a form of event-based systems, in the sense that the information injected to and propagated through the system can be treated as events. A unit in the system can act either/both as information producers (publishers) or/and consumers (subscribers). Subscribers declare their interests via subscriptions to certain events, most commonly specified by the content or the topic of the events (with different expressive power), and publishers produce events of information to the system. The event routing mechanism implemented in the P/S system (usually middleware) aBsTRaCT
Absolute and relative entrainment in Mandarin conversations

Based on Tongji Games Corpus, this study analyzes acoustic-prosodic entrainment in Mandarin conversations. Analyses have been accomplished at the levels of conversation, turn, and tone unit. Absolute entrainment in prosody is found at the levels of conversation and turn, and relative entrainment is found over tones. Therefore, this study identifies evidence for the existence of two kinds of entrainment in Mandarin conversations.
Market Power, Production (Mis)Allocation, and OPEC

This paper estimates the extent to which market power is a source of production misallocation. Productive inefficiency occurs through more production being allocated to higher-cost units of production, and less production to lower-cost production units, conditional on a fixed aggregate quantity. We rely on rich micro-data covering the global market for crude oil, from 1970 to 2014, to quantify the extent of productive misallocation attributable to market power exerted by the OPEC. We find substantial productive inefficiency attributable to market power, ranging from 14.1 percent to 21.9 percent of the total productive inefficiency, or 105 to 163 billion USD.
Towards an understanding of Temporary Supply Chains : a study of organisations and technology

This thesis is concerned with the understanding of Temporary Supply Chains (TSCs) and with the role of Information Technology (IT) in managing them. These supply chains are characterized by finite-life duration, largely emergent and non-routine tasks, and heterogeneity of organisational members. IT assumes a central role, as these supply chains often involve the integration of independent and decentralized organisations. Furthermore, coordination and communication of many agents in real time are critical aspects that are facilitated by technology. Despite this evident practical application, a deep understanding of IT use in TSCs is lacking. Therefore, this piece of research investigates the nature and dynamics of TSCs, focusing on the role of IT. For this, it builds from three fields of knowledge: Operations and Supply Chain Management (O&SCM), Temporary Organisations (TO), and Information Systems (IS). As main research methods, it adopts qualitative case studies. Specifically, it analyses two polar empirical settings: the 2014/2015 Ebola Response in West Africa and the 2016 Olympic Games in Brazil. Given that this is a PhD by publication, the main research findings are reported in the format of three academic papers, which have different focuses and units of analysis. Paper One unveils the dynamics of TSCs by exploring how these supply chains are initiated, develop, and terminate. Paper Two examines intra-firm coordination in temporary organisations. Specifically, it identifies and explains how operational coordination evolves over time in a particular TO: the 2016 Olympic Games Organising Committee (OGOC). Paper Three focuses specifically on the role of IT and investigates process level IT-business alignment in the OGOC longitudinally. This thesis contributes to theory and practice by developing the understanding on how ‘temporariness’ impacts organisational aspects in different levels of analysis: supply chains, organisations, and processes. Furthermore, it contributes to the understanding of the role of IT in temporary contexts. By analysing TSCs, where the temporal nature of supply chain processes is particularly highlighted, this piece of work provides insights into episodes of temporariness in supply chains more generally. Hopefully, this study’s findings can help both scholars and practitioners better recognise the specificities and related challenges in managing in temporary organisational settings.
Distributed mixed protection mechanism for dynamic traffic in WDM optical networks

Single type of protection for dynamic traffic on WDM network is well-studied, and most protection allocation mechanisms are based on the centralized control. In this paper, we will investigate the mixed-mode protection strategy for the connections in the network, under the assumption of single link failure model. Two types of protection resource allocation methods are proposed. The distributed decision process of working and protection resource is presented. The essential modification for original routing packet is also described. The improvement on performance for the proposed mechanism is verified by conducted simulations.
Adaptive patient enrichment designs in therapeutic trials

The utility of clinical trial designs with adaptive patient enrichment is investigated in an adequate and well‐controlled trial setting. The overall treatment effect is the weighted average of the treatment effects in the mutually exclusive subsets of the originally intended entire study population. The adaptive enrichment approaches permit assessment of treatment effect that may be applicable to specific nested patient (sub)sets due to heterogeneous patient characteristics and/or differential response to treatment, e.g. a responsive patient subset versus a lack of beneficial patient subset, in all patient (sub)sets studied. The adaptive enrichment approaches considered include three adaptive design scenarios: (i) total sample size fixed and with futility stopping, (ii) sample size adaptation and futility stopping, and (iii) sample size adaptation without futility stopping. We show that regardless of whether the treatment effect eventually assessed is applicable to the originally studied patient population or only to the nested patient subsets; it is possible to devise an adaptive enrichment approach that statistically outperforms one‐size‐fits‐all fixed design approach and the fixed design with a pre‐specified multiple test procedure. We emphasize the need of additional studies to replicate the finding of a treatment effect in an enriched patient subset. The replication studies are likely to need fewer number of patients because of an identified treatment effect size that is larger than the diluted overall effect size. The adaptive designs, when applicable, are along the line of efficiency consideration in a drug development program.
Social viewing behavior in social TV: proposing a new concept of socio-usability

Purpose – The purpose of this paper is to examine whether and how usability and sociability differ in the way they influence users’ experiences using social TV (STV). Design/methodology/approach – The research model is theoretically proposed and empirically tested through a survey of STV users in South Korea. The model was analysed using structural equation modelling, and the results were input to a neural network model to predict adoption. Findings – Users differ in their emphasis on the identified dimensions when they view STV and socialise through it. Furthermore, the findings show the mediating and moderating roles of perceived sociability on the effect of performance on intention. That is, with sociability, users perceive higher utilitarian value and enjoyable hedonic value and thus are more likely to intend to use STV. Research limitations/implications – The implications of these findings are discussed in terms of building a theory of sociability and providing practical insights into developing a me.
Deep learning for multimedia processing-Predicting media interestingness

This thesis explores the application of a deep learning approach for the prediction of media interestingness. Two different models are investigated, one for the prediction of image and one for the prediction of video interestingness. For the prediction of image interestingness, the ResNet50 network is fine-tuned to obtain best results. First, some layers are added. Next, the model is trained and fine-tuned using data augmentation, dropout, class weights, and changing other hyper parameters. For the prediction of video interestingness, first, features are extracted with a 3D convolutional network. Next a LSTM network is trained and fine-tuned with the features. The final result is a binary label for each image/video: 1 for interesting, 0 for not interesting. Additionally, a confidence value is provided for each prediction. Finally, the Mean Average Precision (MAP) is employed as evaluation metric to estimate the quality of the final results.
Electron penetration into the nucleus and its effect on the quadrupole interaction

A series expansion of the interaction between a nucleus and its surrounding electron distribution provides terms that are well-known in the study of hyperfine interactions: the familiar quadrupole interaction and the less familiar hexadecapole interaction. If the penetration of electrons into the nucleus is taken into account, various corrections to these multipole interactions appear. The best known correction is a scalar term related to the isotope shift and the isomer shift. This paper discusses a related tensor correction, which modifies the quadrupole interaction if electrons penetrate the nucleus: the quadrupole shift. We describe the mathematical formalism and provide first-principles calculations of the quadrupole shift for a large set of solids. Fully relativistic calculations that explicitly take a finite nucleus into account turn out to be mandatory. Our analysis shows that the quadrupole shift becomes appreciably large for heavy elements. Implications for experimental high-precision studies of quadrupole interactions and quadrupole moment ratios are discussed. A literature review of other small quadrupole-like effects is presented as well (pseudoquadrupole effect, isotopologue anomaly, etc.).
Project 3: Economic and Investment Models For Future Grids Deliverable 2: The Scenarios

This chapter sets out the design of a scenario framework for the CSIRO Future Grid Cluster’s Project 3. It sets out how the various influences, or driving forces, are separated into four categorised. These being: Policy, States of the World, Sensitivities, and Linkages. The first two, policy, and states of the world, are then further broken down into two sub-categories: supply side influences, and demand side influences. Additionally, we take into account the reports from the CSIRO’s Future Grid Forum (CFGF), describing the comprehensive supply chain end-to-end study that used four major scenarios that are related to the scenario framework described her to be used in this cluster. The Forum also conducted sensitivities around these four scenarios. In section 1.3 of this document we describe the relationship between the CFGF scenarios and our scenario framework.
68Ga-DOTANOC PET/CT Allows Somatostatin Receptor Imaging in Idiopathic Pulmonary Fibrosis: Preliminary Results

Interstitial lung diseases include different clinical entities with variable prognoses. Idiopathic pulmonary fibrosis (IPF), the most common, presents the most severe outcome (death within 3–5 y), whereas nonspecific interstitial pneumonia (NSIP) shows a more indolent progression. Preclinical evidence of somatostatin receptor (SSTR) expression on fibroblasts in vitro and in lung fibrosis murine models, coupled with the longer survival of mice with fibrotic lungs treated with agents blocking SSTR, supports the hypothesis of imaging fibroblast activity in vivo by visualization of SSTR with 68Ga-DOTANOC PET/CT. The aim of this study was to evaluate 68Ga-DOTANOC PET/CT in patients with IPF and NSIP. Methods: Seven IPF patients and 7 NSIP patients were included in the study. 68Ga-DOTANOC PET/CT and high-resolution CT (HRCT) were performed in all cases by following a standard procedure. PET/CT results were compared with disease sites and extent on HRCT. Results: In IPF, 68Ga-DOTANOC uptake was peripheral, subpleural, and directly correlated with pathologic areas on HRCT (subpleural/reticular fibrosis, honeycombing). NSIP patients showed fainter tracer uptake, whereas corresponding HRCT showed areas of ground-glass opacity and rare fibrotic changes. Only IPF patients showed a linear correlation between maximal SUV and disease extent quantified both automatically (Q) (IPF: P = 0.002, R = 0.93) and using the visual score (Spearman ρ = 0.46, P = 0.0001). Q directly correlated with percentage carbon monoxide diffusing capacity in IPF (P = 0.03, R = 0.79) and NSIP (P = 0.05, R = 0.94), whereas maximal SUV did not present any correlation with percentage carbon monoxide diffusing capacity. Conclusion: Our preliminary data show that 68Ga-DOTANOC PET/CT demonstrates SSTR overexpression in IPF patients; this may prove interesting for the evaluation of novel treatments with somatostatin analogs.
UMBRELLA TESTS FOR RIGHT-CENSORED SURVIVAL DATA

This paper considers the problem of testing for umbrella alternatives in the one-way layout when survival data are subject to random right censorship. Testing procedures based on two-sample weighted logrank statistics are suggested for both cases when the peak of the umbrella is known or unknown. The Pitman efficacy of the peak-known umbrella test is derived. A class of Lehmann and scale alternatives for which the peak-known umbrella test is optimal in the sense of Pitman efficacy is then obtained under the assumption of equal censorship. Moreover, the results of a Monte Carlo study to investigate the level and power performances of the proposed umbrella tests are presented. Finally, application of the proposed procedures to an appropriate data set is illustrated.
Secular trends in stroke incidence and survival, and the occurrence of dementia.

See related article, pages 1155–1159 The 20th century witnessed marked improvements in public health and drastic reductions in mortality from common diseases of early- and midlife leading to a large and growing segment of the population over the age of 65.1 These demographic trends are expected to continue in the coming decades.1 As a result, demographers are forecasting an increase in the number of persons with common chronic conditions of aging. Among the most common, most feared, and most expensive conditions for individuals, families, and society is progressive dementia. Recent data suggest that the number of persons with dementia in the world will increase markedly over the coming decades.2,3 Accurate forecasts of the occurrence of dementia and other age-related conditions in the future are essential for proper public health planning. However, such forecasts rely on a number of assumptions in addition to census projections regarding fertility, mortality, and immigration. For example, after Alzheimer disease, stroke is generally considered to be the second most common cause of dementia.4,5 Recent data suggest that the lifetime risk of both stroke and dementia are very high.6 In addition, health care utilization costs of dementia related to stroke appears to exceed that of Alzheimer disease on a per patient basis.7,8 These data suggest that recent trends in the incidence of and survival from stroke could …
Association of energy intake and expenditure with obesity: A cross-sectional study of 150 pediatric patients following treatment for leukemia

ABSTRACT Increased obesity in leukemia survivors has been attributed to chemotherapy and radiation. Data on total energy intake (TEI) and total energy expenditure (TEE) are lacking in obese childhood leukemia patients after completion of therapy from India. We conducted a cross-sectional study in pediatric acute leukemia patients after completion of therapy wherein energy intake was assessed by 24-hour recall method. TEE was calculated using Harris–Benedict equation, by assessing the physical activity level using Physical Activity Questionnaire for children and basal metabolic rate by World Health Organization equation. Indian Academy of Pediatrics 2015 guidelines for BMI were used for defining overweight and obesity. Nutritional status was assessed in 150 leukemia patients after completion of therapy. Twenty-five percent of leukemia patients after completion of therapy were overweight and obese versus 11% of healthy controls (p = 0.042). The mean ratio of TEI/required energy intake (REI), TEE/required energy expenditure (REE), and (TEI:REI)/(TEE:REE) were significantly higher in overweight and obese group versus nonobese survivors (p < 0.001, p = 0.091, p < 0.001, respectively). Multivariate analysis showed higher income (HR-2.3, p = 0.04), increased TEI/REI (HR-4, p = 0.049) and higher (TEI:REI)/(TEE:REE) (HR-3.1, p = 0.039) to be significant factors predicting obesity. Obesity in leukemia patients after completion of therapy is associated with increased energy intake, causing imbalance between energy intake and TEE in these patients.
Isolation of Human Monoclonal Antibodies That Potently Neutralize Human Cytomegalovirus Infection by Targeting Different Epitopes on the gH/gL/UL128-131A Complex

ABSTRACT Human cytomegalovirus (HCMV) is a widely circulating pathogen that causes severe disease in immunocompromised patients and infected fetuses. By immortalizing memory B cells from HCMV-immune donors, we isolated a panel of human monoclonal antibodies that neutralized at extremely low concentrations (90% inhibitory concentration [IC90] values ranging from 5 to 200 pM) HCMV infection of endothelial, epithelial, and myeloid cells. With the single exception of an antibody that bound to a conserved epitope in the UL128 gene product, all other antibodies bound to conformational epitopes that required expression of two or more proteins of the gH/gL/UL128-131A complex. Antibodies against gB, gH, or gM/gN were also isolated and, albeit less potent, were able to neutralize infection of both endothelial-epithelial cells and fibroblasts. This study describes unusually potent neutralizing antibodies against HCMV that might be used for passive immunotherapy and identifies, through the use of such antibodies, novel antigenic targets in HCMV for the design of immunogens capable of eliciting previously unknown neutralizing antibody responses.
The effect and the Challenges of Implementing Total Quality Management on Performance of Higher Education Institutions

This study aims to identify the total quality management and its impact on the efficiency ofacademic performance in Jordanian universities , through the knowledge level of the applicationof the principles of total quality management in the University of Jordan, from the viewpoint ofits employees ( faculty members ) and to identify the most TQM principles applied in theuniversity as seen employees faculty members and activating the role of interested andadministrators Jordan University , and other universities to apply the principles of total qualitymanagement and work on enhancing them as well as to identify the requirements of the overallquality of the educational system and to identify the appropriateness of the education system atthe University of Jordan to total quality management . So is the problem of the study in a surveyTQM principles applied in the University of Jordan, as perceived by its employees through a fourprinciples of quality requirements in education, follow-up of the educational process, thedevelopment of human resources (faculty members), and academic administration decisions. Thestudy found many of the recommendations the most important need to focus senior managementin educational institutions on the process of applying the principles of total quality managementto improve the system of university education and guide the process of decision-making in Jordanian universities , especially the University of Jordan in the preparation of the cadres of theAcademy are eligible to lead the process of change and the impact on efficiency and productivityto reach the learning outcomes high quality and the need for attention out of total qualitymanagement as a specific quality assurance process in organizations that do not aim to profit anyservice organizations such as educational.