Miracle-dz/UniFAR-FTUs huggingface dataset:
Distinct mouse coronary anatomy and myocardial infarction consequent to ligation

This study describes the coronary anatomy of C57BL/6 mice and the functional impact of that anatomy on myocardial infarctions induced by ligation of the left coronary artery. In contrast to humans, a distinct septal coronary artery was observed in all mice arising either from a separate ostium from the right sinus of Valsalva or as a branch of the right coronary artery. Ligation of the left coronary artery at the site of its emergence from under the left atrium resulted in reproducible large myocardial infarctions involving the anterolateral, posterior, and apical regions of the heart as evidenced by histology and echocardiography. Interestingly, the septum was spared from infarction as predicted by the presence of the distinct septal branch found in mice. Thus, the distinct mouse coronary artery anatomy results in different regionality of infarction compared with man and large laboratory animals, and this may affect on the associated pathological remodeling of the heart. BackgroundThe objective of this study was to describe the coronary anatomy of C57BL/6 mice and determine the functional impact of that anatomy on myocardial infarctions induced by ligation of the left coronary artery. MethodsC57BL/6 mice were used to visualize mouse coronary anatomy and to generate myocardial infarction. Mouse coronary artery visualization was performed on isolated hearts using injection of Silastic sealant into the aortic arch. After left thoracotomy myocardial infarction was produced by ligating the left coronary artery at the site of the vessels' emergence past the tip of the left atrium. Echocardiography was performed to analyze heart function, and histology was performed to delineate myocardial infarction. ResultsThe different septal coronary artery was observed in all mice arising either from a separate ostium from the right sinus of Valsalva or as a branch of the right coronary artery. The mouse left coronary artery passed obliquely across the left ventricular free wall similar to the ramus intermedius coronary artery variant in man. Ligation of the left coronary artery as it emerged from under the left atrium resulted in reproducible large infarctions involving the anterolateral, posterior, and apical regions of the heart as demonstrated by histology and echocardiography. Notably, the septum was spared from infarction as predicted by the presence of the distinct septal coronary artery found in mice. ConclusionsMouse coronary anatomy is distinct compared to man or large laboratory animals, and myocardial infarctions resulting from ligation of the mouse left coronary artery spare the septum, which may affect the pathological remodeling of the heart.
Safety and Pharmacokinetics of P792, a New Blood-Pool Agent: Results of Clinical Testing in Nonpatient Volunteers

Gaillard S, Kubiak C, Stolz C, et al. Safety and pharmacokinetics of P792, a new blood-pool agent: results of clinical testing in nonpatient volunteers. Invest Radiol 2002;37:161–166. rationale and objectives. To evaluate the safety and pharmacokinetics of P792, a new macromolecular blood-pool agent for magnetic resonance imaging (MRI), in nonpatient volunteers. methods. This was a single blind, placebo-controlled, ascending-dose study in 32 healthy male volunteers, randomized to receive a single intravenous dose of P792 (0.0065, 0.013, 0.026, and 0.039 mmol/kg). The safety controls consisted of complete pre- and postdose physical examinations, measurement of vital signs, clinical laboratory investigations, and monitoring of adverse events (up to 22 days after injection). For pharmacokinetic analysis, the determination of P792 was performed using the ICP-MS technique for blood and urine samples up to 22 days. results. No serious adverse events occurred during the study. There were no clinically significant changes in vital signs, or clinical laboratory findings. P792 blood half-life, distribution volume, and renal clearance are consistent with the definition of a rapid clearance blood-pool agent (RCBPA) as defined previously. conclusion. P792 appeared to be a safe and well-tolerated RCBPA in nonpatient subjects. Phase II studies will be conducted to evaluate the efficacy of the blood-pool agent for vascular, perfusion, and permeability imaging in MRI.
The comparison of PHD algorithms with adaptive target birth

Probability hypothesis density (PHD) filter has received extensive attention because of its good performance in target tracking. Considering engineering practicability and traditional PHD filter implementation, several commonly adaptive PHD algorithms for newborn target intensity have been presented and analyzed in this paper. The comparative analysis including two categories filters and both of them are used for adapting newborn target intensity: measurement-driven extended PHD filter under sequential Monte Carlo (SMC) framework and measurement-gate partition based PHD filter under Gaussian mixture (GM) framework. The performance of different algorithms is verified from the aspects of state estimation precision, target number estimation and simulation time, which provides technical support for engineering applications.
PENGARUH STORE ATMOSPHERE, HEDONIC MOTIVE DAN SERVICE QUALITY TERHADAP KEPUTUSAN PEMBELIAN

ABSTRACT The purpose of this research is to find out the store atmosphere, hedonic motive and service quality to the purchasing decision at Excelso Plaza Marina, and to find out among store atmosphere, hedonic motive, and service quality which one of these variables give dominant influence to the purchasing decision at Excelso Plaza Marina. The population is all customers who have ever visited and conducted purchasing decision. This research is a descriptive research and the data is the primary data. The type of data is the subject data whereas the sample collection technique has been done by using purposive sampling and 100 respondents have been selected as samples. The analysis technique has been carried out by using multiple linear regressions analysis. The result of the research shows that the influence of store atmosphere, hedonic motive and service quality to the purchasing decision is positive. And the variable which gives dominant influence to the purchasing decision is service quality. It shows that the truth of the whole hypothesis in this research have been proven. Keywords: store atmosphere, hedonic motive, service quality, purchasing decision
Why do consumers choose sustainable fashion? A cross-cultural study of South Korean, Chinese, and Japanese consumers

Abstract This research aims to study consumers in South Korea, China, and Japan to better understand their decision-making processes regarding sustainable fashion, an area where demands are increasing for countering negative environmental impacts. Consumers sometimes fail to align their behavior with their positive attitudes toward sustainable consumption. In addition, they have cross-cultural differences in their attitudes and eWOM intentions toward sustainable fashion products (SFP). This study (1) investigates whether environmental concerns and product knowledge of SFP may increase SFP purchasing, (2) identifies factors influencing eWOM intentions, and (3) investigates marketing approaches and cross-cultural differences in the SFP context. Findings suggest that consumers have positive attitudes toward SFP when they perceive that the products have value but not when they perceive risks. The research gives marketing insights into methods for enhancing sustainable fashion consumption.
Role of protein kinase C- e in hypertrophy of cultured neonatal rat ventricular myocytes

Role of protein kinase C- e in hypertrophy of cultured neonatal rat ventricular myocytes. Am J Physiol Heart Circ Physiol 280: H756–H766, 2001. —Using adenovirus (Adv)-mediated overexpression of constitutively active (ca) and dominant-negative (dn) mutants, we examined whether protein kinase C (PKC)- e , the major novel PKC isoenzyme expressed in the adult heart, was necessary and/or sufﬁcient to induce speciﬁc aspects of the hypertrophic phenotype in low-density, neonatal rat ventricular myocytes (NRVM) in serum-free culture. Adv-caPKC- e did not increase cell surface area or the total protein-to-DNA ratio. However, cell shape was markedly affected, as evidenced by a 67% increase in the cell length-to-width ratio and a 17% increase in the perimeter-to-area ratio. Adv-caPKC- e also increased atrial natriuretic factor (ANF) and b -myosin heavy chain (MHC) mRNA levels 2.5 6 0.3- and 2.1 6 0.2-fold, respectively, compared with NRVM infected with an empty, parent vector ( P , 0.05 for both). Conversely, Adv-dnPKC- e did not block endothelin-induced increases in cell surface area, the total protein-to-DNA ratio, or upregulation of b -MHC and ANF gene expression. How-ever, the dominant-negative inhibitor markedly suppressed endothelin-induced extracellular signal-regulated kinase (ERK) 1/2 activation. Taken together, these results indicate that caPKC- e overexpression alters cell geometry, producing cellular elongation and remodeling without a signiﬁcant, overall increase in cell surface area or total protein accumulation. Furthermore, PKC- e activation and downstream signaling via the ERK cascade may not be necessary for cell growth, protein accumulation, and gene expression changes induced by endothelin.
Role of Proteolytic Enzyme Inhibitors on Carious and Eroded Dentin Associated With a Universal Bonding System.

OBJECTIVES The aim of this study was to evaluate the effect of proteolytic inhibitors on the bond strength of a universal adhesive system (etch-and-rinse mode) applied to artificial carious and eroded dentin. METHODS Ninety molars were prepared and randomly divided into three groups according to the substrate: N, no challenges; ACD, artificial carious dentin simulation and ERO, artificial erosion simulation with orange juice. All groups were redivided into three subgroups according to the dentin pretreatment: W, water; CHX, 2% digluconate chlorhexidine; and E-64 (trans-epoxysuccinyl-L-leucylamido-[4-guanidino] butane), 5 μM E-64 inhibitor. They constituted a total of nine groups (n=10): N-W, N-CHX, N-E64, ACD-W, ACD-CHX, ACD-E64, ERO-W, ERO-CHX, and ERO-E64. All specimens were restored with Adper Single Bond Universal/Filtek Z250. Beams (0.64 mm2) were obtained and subjected to the microtensile test (μTBS) in a universal testing machine at 0.5 mm/min. The failure mode of the interfaces was determined by optical microscopy (40× magnification). Data were statistically analyzed by three-way analysis of variance and Tukey tests (p<0.05). RESULTS All individual factors (p<0.0001) and the interaction between substrate and treatment (p=0.0011) and between substrate and time (p=0.0003) were statistically significant. The caries substrate contributed negatively to bond strength. Chlorhexidine reduced bond strength for normal and eroded conditions. Only the normal substrate was negatively affected by time despite the pretreatment. CONCLUSIONS The universal bonding system appears to be a promising bonding strategy for the maintenance of bond strength to affected dentin. E-64 did not affect bonding to the dentin in contrast to the use of chlorhexidine, which, when associated with the universal system, did affect the microtensile bond strength for artificial carious dentin.
SIMULTANEOUS DETERMINATION OF METOPROLOL SUCCINATE AND CHLORTHALIDONE BY UV SPECTROPHOTOMETRIC METHOD

A simple and rapid UV spectrophotometric method has been developed for simultaneous estimation of Metoprolol Succinate (MET) and Chlorthalidone (CLT). The absorbances of both drugs were found at 267nm and 243 nm in the range of 12-28 µg/ml (y=0.0024X+0.001; r =0.9996) and 3-7µg/ml (y= -0.0149x+0.0015; r = 0.9991) respectively for MET and CLT in methanol 2 2 solvent system.267 nm and 243 nm were zero crossing point for CLT and MET respectively in first order derivative of UV spectrophotometry. Accuracy and reproducibility of the proposed method was statistically validated by recovery studies. This method is found to be precise and accurate and can easily be employed in the laboratory for the routine estimation of drugs.
Simulative model for evaluation of investment processes in the regions of Ukraine

To analyze and evaluate the investment processes in the regions of Ukraine, it is suggested to use a simulative model that, unlike existing ones, allows to take into account the influence of macroeconomic factors and to predict the future development of the economic system of the regions taking into account their investment potential. The examination of the assessed simulative models of the investment processes in the regions of Ukraine for adequacy is carried out using the determination coefficient and Fisher’s criterion, by which the influence of the most significant economic variables of social and economic development of the regions on the investments formation is determined. Research of the investments impact on the dynamics of economic systems indicators of the regions has shown that 86% of the constructed models are adequate. The presence of statistically significant estimates of model parameters confirms the effectiveness of the proposed approach for conducting research on the analysis and forecasting of the patterns of significant indicators formation of investment activity at the regional level, as well as their impact on indicators of social and economic development.
Changes in pigments and photosynthetic parameters of cowpea under two inorganic arsenicals

A net house experiment was conducted to investigate the relative effects of two inorganic forms of arsenic namely, arsenate (As V) and arsenite (As III), on some physiological parameters in leaves of cowpea (Vigna unguiculata L. Walp) cv. BCKV-1. Cowpea plants were grown in pot culture and were treated with different doses of As (V) and As (III) as 0 (control) 10, 20, 30 and 40 mg L -1 . The application of arsenic in either form showed an adverse effect on pigment and protein contents, net photosynthesis, transpiration rate, stomatal conductance especially at higher doses of 30 and 40 mg L 1 . A higher reduction in photosynthetic pigments, protein, transpiration rate and stomatal conductance were recorded in As (III) treatments than As (V), while net photosynthetic rate and intrinsic water use efficiency (IWUE) were most severely affected in As (V).
On the Evolvability of Monotone Monomials with a (1+1) Evolutionary Algorithm

Diochnos in (2016) showed that Valiant’s swapping algorithm for monotone monomials converges efﬁciently under binomial distributions characterized by any 0 < p < 1 , for a sufﬁ-ciently large instance dimension n . We continue the study on the evolution of monotone monomials in Valiant’s framework of evolvability. In particular we prove that a (1+1) evolutionary algorithm, in a distribution-speciﬁc sense, evolves, with probability at least 1 − δ , a monomial that is ε -optimal, for every binomial distribution characterized by a real algebraic number p ∈ (0 , 1 / 3] ∪ { 1 / 2 } in O (cid:0) n 2 qδ − 1 (cid:1) generations, where q = ⌈ log 1 /p (3 /ε ) ⌉ is a parameter called frontier . The sample size is e O (cid:0) n 2 qδ − 1 ε − 2 (min { 4 pε/ 9 , 1 − 3 p } ) − 2 (cid:1) when 0 < p < 1 / 3 and e O (cid:0) n 2 qδ − 1 ε − 4 (cid:1) when p = 1 / 3 or p = 1 / 2 , where e O ( · ) ignores poly-log factors but not the parameter q itself. Further, a slight modiﬁcation of the algorithm evolves, with probability at least 1 − δ , an ε - optimal hypothesis, in a distribution-independent sense, for a class of distributions. For a real algebraic number 0 < α < 3 / 13 , letting k = ⌈ log 2 (1 / α ) ⌉ , this is done for every binomial distribution characterized by an arbitrary real p ∈ [ α , 1 / 3 − 4 α / 9] ∪ { 1 / 3 } ∪ { 1 / 2 } , in O (cid:0) n 2 qδ − 1 (cid:1) generations using total sample size e O (cid:0) 6 4 k n 2 qδ − 1 ε − 4 k (cid:1) where q = ⌈ log 2 (3 /ε ) ⌉ this time. Both algorithms are the ﬁrst in the framework of evolvability that allow partial random walks and do not necessarily follow strictly beneﬁcial steps until an ε -optimal hypothesis is formed.
Ask and you shall receive: desire and receipt of feedback via Facebook predicts disordered eating concerns.

OBJECTIVE The current study examined whether certain types of Facebook content (i.e., status updates, comments) relate to eating concerns and attitudes. METHOD We examined the effects of seeking and receiving negative feedback via Facebook on disordered eating concerns in a sample of 185 undergraduate students followed for approximately 4 weeks. RESULTS Results indicated that individuals with a negative feedback seeking style who received a high number of comments on Facebook were more likely to report disordered eating attitudes four weeks later. Additionally, individuals who received extremely negative comments in response to their personally revealing status updates were more likely to report disordered eating concerns four weeks later. DISCUSSION Results of the current study provide preliminary evidence that seeking and receiving negative feedback via social networking sites can increase risk for disordered eating attitudes, and suggest that reducing maladaptive social networking usage may be an important target for prevention and intervention efforts aimed at reducing disordered eating attitudes.
Secure Transmission Scheme Design for SWIPT in Buffer-aided Relay Networks

In this paper, we investigate a secure relaying network with simultaneous wireless information and power transfer (SWIPT). It is assumed that Alice wants to send confidential information to Bob under the existence of a passive eavesdropper (Eve), while the relay is equipped with a data buffer and an energy storage device. More specifically, we aim at achieving higher secrecy throughput, while retaining the stability of the data and energy queues. To achieve this with acceptable complexity, we transform the original long-term stochastic optimization problem into a series of online subproblems using the framework of Lyapunov optimization. The proposed scheme shows that the optimal time switching factor is 0 or 1, which is different from the conventional secure relaying network with SWIPT. In addition, simulation results verify that the proposed scheme can improve the secrecy throughput compared with the baseline scheme.
Adenovirus-dependent changes in cell membrane permeability: role of Na+, K+-ATPase

Adenovirus-dependent release of choline phosphate from KB cells at pH 6.0 was partially blocked by ouabain. In K+-containing medium, maximum inhibition of release was obtained by 10(-5) M ouabain and half-maximal inhibition was achieved by about 0.5 X 10(-6)M ouabain. Ouabain did not block either the binding or the uptake of adenovirus by KB cells. Without K+, about 25% of cell-associated choline phosphate was released by adenovirus, whereas with 1 mM K+ about 50% was released. This activation by K+ was blocked by 0.1 mM ouabain. HeLa cells behaved like KB cells, but a mutant of HeLa cells resistant to ouabain (D98-OR) released much lower amounts of choline phosphate in response to human adenovirus type 2 (Ad2). Wild-type D98-OR cells bound nearly the same amount of adenovirus as did normal HeLa cells. Ad2 also increased the activity of Na+,K+-ATPase in KB cells, with maximum activation at 50 micrograms of Ad2 per ml. In D98-OR cells, Ad2 failed to activate Na+,K+-ATPase activity. Ad2-dependent lysis of endocytic vesicles (receptosomes) was assayed by measuring Ad2-dependent enhancement of epidermal growth factor-Pseudomonas exotoxin toxicity. This action of adenovirus was increased when K+ was present in the medium. Under the conditions used, K+ had no effect on the amount of Ad2 or epidermal growth factor taken up by the cells. On the basis of these results, it is suggested that Ad2-dependent cellular efflux of choline phosphate and adenovirus-dependent lysis of receptosomes may require Na+,K+-ATPase activity.
Enhancing user fairness in non-orthogonal access with successive interference cancellation for cellular downlink

Aiming at a better tradeoff between the system frequency efficiency measured by the mean user throughput and the user fairness measured by the cell-edge user throughput, we propose applying fractional frequency reuse (FFR) and weighted proportional fair (PF)-based multiuser scheduling to non-orthogonal access with a successive interference canceller (SIC) in the cellular downlink. We also propose a frequency block access policy for cell-interior and cell-edge user groups in FFR, which are appropriate for non-orthogonal access with the SIC. The optimum power is allocated to the non-orthogonally multiplexed users in conjunction with the weighted multiuser PF scheduler. Extensive simulation results show that the proposed non-orthogonal access scheme with the SIC significantly enhances the system frequency efficiency and user fairness at the same time compared to orthogonal access, which is widely used in 3.9 and 4G mobile communication systems.
Assay-Determined Values of Various Known Quantities of Human Parathyroid Tissue Culture Media Treated as “ Unknown Specimens ” in the Parathyrin Radioimmunoassay

A radioimmunoassay for rhesus monkey and human immunoreactive parathyrin was developed in which a selected anti-bovine parathyrin antiserum, radioiodinated purified bovine parathyrin tracer, and human parathyroid tissue-culture media standards were used. The resulting data indicate that (a) the method is sensitive, specific, accurate and reproducible; (b) it is valid for both the rhesus monkey and the human; (C) the serum immunoreactive parathyrin concentration of the monkey is essentially the same as that in man; (d) monkey immunoreactive parathyrin responds to changes in serum calcium concentration similarly to that in man; and (e) the rhesus monkey is therefore a suitable species in which to study parathyroid physiology, from which conclusions can be applied to the human.
A Model Unavailability Perspective of Existing Nigerian Township Electricity Distribution

The study aimed to investigate and obtain model values of system unavailability and cost of energy not supplied in existing Nigerian township electricity distributions using a robust representative system. Outage data was obtained from system records for analysis using frequency distribution statistics to identify the causes of outages, and the contribution of each cause of outage to the overall system outage. The cost of energy not supplied (CENS) due to faults, was evaluated at a rate of NGN6 per kWHr. An analysis of the results shows that in a distribution feeder (and system) unavailability is mainly due to load shedding arising and faults; feeder unavailability involving load shedding is 0.25, and 0.1 without load shedding. Compared with standard UA value for well managed systems of less than or 0.01, the obtained unavailability values for a feeder show that downtime management was poor, and the corresponding cost – prohibitive. In view of the regular load shedding on the feeders and poor downtime management, this study recommends a need to obtain model loadflow perspective of township electricity distribution to ascertain load carrying capacity, and the application of distribution automation system or other effective strategies to mitigate downtime.