Miracle-dz/UniFAR-FTUs huggingface dataset:
Plasma Concentrations of Quetiapine, N-Desalkylquetiapine, O-Desalkylquetiapine, 7-Hydroxyquetiapine, and Quetiapine Sulfoxide in Relation to Quetiapine Dose, Formulation, and Other Factors

Background: N-Desalkylquetiapine may be a pharmacologically active quetiapine metabolite. However, information on plasma concentrations of N-desalkylquetiapine and other quetiapine metabolites attained during quetiapine therapy is scant. The aim of this study was to investigate plasma concentrations of quetiapine, N-desalkylquetiapine, O-desalkylquetiapine, 7-hydroxyquetiapine, and quetiapine sulfoxide attained during therapy and analyze the data with respect to prescribed dose and other variables. Method: Quetiapine and its metabolites were measured in plasma samples submitted for quetiapine therapeutic drug monitoring (2009–2011). Concentration, metabolic ratio, and concentration corrected for dose (C/D) were investigated against quetiapine dose, age, sex, and formulation. Sample results were excluded if nonadherence with therapy was queried. Results: There were 99 samples from 59 patients. N-Desalkylquetiapine plasma concentrations showed the strongest correlation with dose of all analytes, but O-desalkylquetiapine and quetiapine sulfoxide were strongly correlated to plasma quetiapine concentrations. There was no significant difference in C/D for any analyte between males and females and no correlation to age. Quetiapine and quetiapine sulfoxide C/D were significantly different (P < 0.01) between patients prescribed immediate- and extended-release formulations. Quetiapine, 7-hydroxyquetiapine and quetiapine sulfoxide C/D showed significant variation (P < 0.02) between those samples taken 10–14 hours postdose as compared with that of 16–24 hours postdose, but there was no significant effect as regards N-desalkylquetiapine. Conclusions: Plasma quetiapine, O-desalkylquetiapine, 7-hydroxyquetiapine, and quetiapine sulfoxide concentrations were significantly affected by formulation and/or time since last dose. Plasma N-desalkylquetiapine concentrations were not affected by either factor therefore may be a better marker for quetiapine exposure than plasma quetiapine concentrations.
The Implications of Direct Participation for Organisational Commitment, Job Satisfaction and Affective Psychological Well‐Being: A Longitudinal Analysis

The article examines the implications of direct participation for employees' organisational commitment, job satisfaction and affective psychological well-being. It focuses on both task discretion and organisational participation. Applying fixed effect models to nationally representative longitudinal data, the study provides a more rigorous assessment of the conflicting claims for the effects of participation that have hitherto been based primarily on cross-sectional evidence. Further, it tests a range of mechanisms by which direct participation leads to improved employee outcomes. Contrary to the critical literature, it shows that even after controlling for unobserved individual heterogeneity, both forms of direct participation have positive effects for employees' organisational commitment and well-being. The effects of task discretion are primarily direct, reflecting the intrinsic importance of personal control over the job task; in contrast, those of organisational participation derive to a greater extent from its indirect effect on the quality of working conditions.
Self-Regulatory Skills for Controlled Eating Emanating from Newly Initiated Physical Activity

The relationship of physical activity with weight loss may largely be due to its association with psychosocial factors. The goal of this research was to clarify such relationships using a field design lasting 24 weeks. In Study 1, change in self-regulation for controlled eating, but not energy expenditure, mediated the relationship between changes in physical activity and weight in formerly sedentary, severely obese adults (n = 174). In Study 2 (n = 148), the addition of a cognitive-behavioral nutrition treatment was associated with significantly greater improvement in self-regulation for eating. Physical activity-related self-regulation changes were related to those improvements. Changes in self-efficacy for controlled eating and mood mediated the prediction of changes in eating-related self-regulation from changes on physical activity-related self-regulation. Change in body satisfaction was not a significant mediator. Based on the findings, practical uses of physical activity to enhance self-regulatory skills for controlled eating were suggested.
Business Process Modeling and Instantiation in Home Care Environments

There are many studies currently being conducted within the field of Home Care, where houses fulfilled with devices and sensors can help users in their daily lives, even the ones with chronicle diseases and disabilities. One important challenge in this area refers to the selection of the device and functionalities that best meets usersâ�� needs based on their context, location and disabilities. In this sense, this paper presents a novel approach for selecting the most appropriate device for the current user context. In our approach, devices and their functionalities are described and represented by Web services, and business processes are used as guidelines that specify procedures that should be taken in the treatment of a home care patient. Therefore, the issue of what device and which of its corresponding functionalities should be selected is treated as an approach to discover and select Web services based on its syntactic and semantic aspects as well as the user context.
Human Cytomegalovirus UL76 Elicits Novel Aggresome Formation via Interaction with S5a of the Ubiquitin Proteasome System

ABSTRACT HCMV UL76 is a member of a conserved Herpesviridae protein family (Herpes_UL24) that is involved in viral production, latency, and reactivation. UL76 presents as globular aggresomes in the nuclei of transiently transfected cells. Bioinformatic analyses predict that UL76 has a propensity for aggregation and targets cellular proteins implicated in protein folding and ubiquitin-proteasome systems (UPS). Furthermore, fluorescence recovery after photobleaching experiments suggests that UL76 reduces protein mobility in the aggresome, which indicates that UL76 elicits the aggregation of misfolded proteins. Moreover, in the absence of other viral proteins, UL76 interacts with S5a, which is a major receptor of polyubiquitinated proteins for UPS proteolysis via its conserved region and the von Willebrand factor type A (VWA) domain of S5a. We demonstrate that UL76 sequesters polyubiquitinated proteins and S5a to nuclear aggresomes in biological proximity. After knockdown of endogenous S5a by RNA interference techniques, the UL76 level was only minimally affected in transiently expressing cells. However, a significant reduction in the number of cells containing UL76 nuclear aggresomes was observed, which suggests that S5a may play a key role in aggresome formation. Moreover, we show that UL76 interacts with S5a in the late phase of viral infection and that knockdown of S5a hinders the development of both the replication compartment and the aggresome. In this study, we demonstrate that UL76 induces a novel nuclear aggresome, likely by subverting S5a of the UPS. Given that UL76 belongs to a conserved family, this underlying mechanism may be shared by all members of the Herpesviridae.
OPTIMIZATION OF EBG STRUCTURES BY USE OF GLOBAL OPTIMIZATION ALGORITHMS

Planar dielectric EBG structures are formed by two-dimensional periodic dielectric inclusions in the dielectric slab. The main design parameters forming the frequencies of stopband are the shape of inclusions and their size, kind of slab it is formed in, lattice constant and both slab and inclusions permittivity constant. While there does not exist a general way how to determine the stopband existence of certain parameter setup analytically it must be simulated by use of numerical methods.
Minor injuries, cognitive failures and accidents at work: incidence and associated features.

BACKGROUND There is a dearth of information examining minor injuries and cognitive failures in the workplace. AIMS This study aims to describe the incidence of, and characteristics associated with, minor injuries, cognitive failures and accidents in the workplace. METHODS The study was a community based postal questionnaire survey of people selected at random from the Electoral Registers of Cardiff and Merthyr Tydfil; 7980 questionnaires were returned. RESULTS Frequent/very frequent minor injuries were reported by 9.8% of the workers and frequent/very frequent cognitive failures (e.g. problems of memory, attention or action) by 10.5%. Work accidents requiring treatment were reported by 5.6% of the workers. Minor injuries, cognitive failures and accidents were associated with a number of demographic and health factors. In addition, minor injuries, cognitive failures and accidents were found to be related to each other. CONCLUSIONS A large number of workers experience accidents and minor injuries at work. Minor injuries are not recorded by official sources but could have implications in productivity and worker health. Factors identified in this study, as associated with injuries or accidents, could be addressed by specific workplace policies or by raising individual awareness of the risks.
Testing synchronous critical software

Three approaches to the problem of testing synchronous critical software are presented, based on the data-flow language LUSTRE. The first approach automatically transforms a set of LUSTRE invariant properties characterizing the environment into a constrained random generator of test data sequences. The second approach consists in analyzing the required safety properties (written in LUSTRE) of the software. This analysis may result, in specific cases, in automatic generators of relevant test data. The third approach considers that LUSTRE is used for the implementation of the software. The usual structure-based testing criteria are adapted to the operator net associated with the LUSTRE nodes. Moreover, an automatic test data generation process is described for this last approach using LESAR, a tool designed to automatically prove the satisfaction of safety properties on LUSTRE programs. <<ETX>>
GaN technology for power RF applications: Present reliability roadblocks and future trends

The current collapse and normally-on devices are the main roadblocks to the wider employment of the GaN technology. To explain the current collapse effect, surface and bulk trapping/de-trapping phenomena are modeled using 2D drift-diffusion and hydro-dynamic transport models by transient simulations within Silvaco TCAD. The current collapse next to 75% and 5% was observed due to surface and bulk trapping, respectively. The combined surface and bulk trapping is studied using a gate-lag technique showing a good qualitative agreement with experimental observations.
The Multiresolution Toolkit: Progressive Access for Regular Gridded Data

Poly(p-benzenesulfonamide) has been prepared by the transamidation of N1,N1-dimethylsulfanilamide hydrochloride in a melt reaction at 180 DEG C. The polymers form brittle films when cast from solution and have a glass transition temperature, Tg, of 180 DEG -190 DEG C. at a degree of polymerization of about 6.
Computed Tomographic Diagnosis of Intraventricular Hemorrhage

Sixty-eight patients with intraventricular hemorrhage (IVH) diagnosed by computed tomography (CT) were reviewed retrospectively to determine the etiology and prognosis, relationship to delayed hydrocephalus, and effect on neurological outcome. The most common causes were a ruptured aneurysm, trauma, and hypertensive hemorrhage. Ruptured aneurysms of the anterior communicating artery can often be predicted from the nonenhanced CT scan. The total mortality rate was 50%; however, 21% of patients returned to normal or had only mild disability. Patients in whom no cause was identified had a better prognosis. Delayed hydrocephalus was related to the effects of subarachnoid hemorrhage rather than obstruction of the ventricular system by blood. IVH per se is seldom a major factor in the neurological outcome.
ABCB 1 C 1236 T , G 2677 T / A and C 3435 T polymorphisms in systemic lupus erythematosus patients

P-glycoprotein (Pgp), the ABCB1 gene product, acts as an efflux pump that transports a large variety of substrates and is a mechanism of cell protection against xenobiotics. An increasing number of studies have shown that some ABCB1 polymorphisms may affect Pgp expression and activity, as well as affecting the development and susceptibility to diseases and pharmacological response. High activity of Pgp has been detected in systemic lupus erythematosus (SLE) patients. The C1236T, G2677T/A, and C3435T are the most commonly studied single nucleotide polymorphisms in the ABCB1 gene. Therefore, their frequencies were determined in Brazilian individuals with European ancestry (N = 143) and in SLE patients (N = 137). Genotyping was performed by PCR-RFLP analysis using specific primers followed by incubation with the appropriate restriction enzymes. The resulting DNA fragments were visualized on agarose or polyacrylamide gels. No statistically significant differences were observed in allelic and genotypic frequencies between SLE and healthy subjects (Fisher exact test). Nevertheless, the 2677A allelic frequency was lower in SLE patients with malar rash (0.007) compared with patients without this feature (0.04; P = 0.0054), while the frequency of this variant was higher in SLE patients with pleuritis (0.07) compared with patients without this feature (0.01; P = 0.0156). We suggest that although the ABCB1 polymorphisms do not directly interfere in SLE susceptibility, their evaluation, especially the 2677A allele, in other immunological processes may be interesting since they can interfere in clinical features of this disease.
Extraction of thymol from different varieties of thyme plants using green solvents.

BACKGROUND Thymol (2-isopropyl-5-methylphenol) is the main monoterpene phenol found in thyme essential oil. This compound has revealed several biological properties, including antibacterial, anti-inflammatory and antioxidant activities. In this work, a comparison was made between the performance of different green solvents (ethanol, limonene and ethyl lactate), by pressurized liquid extraction (PLE) and supercritical fluid extraction (SFE) at different conditions, to extract thymol from three different varieties of thyme (Thymus vulgaris, Thymus zygis and Thymus citriodorus). Additionally, new solubility data of thymol in limonene and ethanol at ambient pressure and temperatures in the range 30-43 °C are reported. RESULTS The highest thymol recoveries were attained with T. vulgaris (7-11 mg g(-1)). No thymol could be quantified in the PLE samples of T. citriodorus. The highest concentrations of thymol in the extracts were obtained with limonene. Thymol is very soluble in both solvents, particularly in ethanol (∼900 mg g(-1) at ∼40 °C), and is the main compound (in terms of peak area) present in the essential oil extracts obtained. CONCLUSION The three solvents show good capacity to extract thymol from T. vulgaris and T. zygis by PLE. Although PLE proved to be a suitable technology to extract thymol from thyme plants, the highest concentrations of thymol were obtained by SFE with supercritical CO2 .
Identification of a novel alpha‐fetoprotein‐expressing cell population induced by the Jagged1/Notch2 signal in murine fibrotic liver

The liver is well known to possess high regenerative capacity in response to partial resection or tissue injury. However, liver regeneration is often impaired in the case of advanced liver fibrosis/cirrhosis when mature hepatocytes can hardly self‐proliferate. Hepatic progenitor cells have been implicated as a source of hepatocytes in regeneration of the fibrotic liver. Although alpha‐fetoprotein (AFP) is known as a clinical marker of progenitor cell induction in injured/fibrotic adult liver, the origin and features of such AFP‐producing cells are not fully understood. Here, we demonstrate a unique and distinct AFP‐expressing cell population that is induced by the Jagged1/Notch2 signal in murine fibrotic liver. Following repeated carbon tetrachloride injections, a significant number of AFP‐positive cells with high proliferative ability were observed along the fibrous septa depending on the extent of liver fibrosis. These AFP‐positive cells exhibited features of immature hepatocytes that were stained positively for hepatocyte‐lineage markers, such as albumin and hepatocyte nuclear factor 4 alpha, and a stem/progenitor cell marker Sox9. A combination of immunohistological examination of fibrotic liver tissues and coculture experiments with primary hepatocytes and hepatic stellate cells indicated that increased Jagged1 expression in activated hepatic stellate cells stimulated Notch2 signaling and up‐regulated AFP expression in adjacent hepatocytes. The mobilization and proliferation of AFP‐positive cells in fibrotic liver were further enhanced after partial hepatectomy, which was significantly suppressed in Jagged1‐conditional knockout mice. Finally, forced expression of the intracellular domain of Notch2 in normal liver induced a small number of AFP‐expressing hepatocytes in vivo. Conclusion: Insight is provided into a novel pathophysiological role of Jagged1/Notch2 signaling in the induction of AFP‐positive cells in fibrotic liver through the interaction between hepatocytes and activated hepatic stellate cells. (Hepatology Communications 2017;1:215‐229)
A New Investigation of Data Retention Time in Truly Nanoscaled DRAMs

Data retention time for ultimate DRAMs with an extremely scaled-down cell size has been investigated. The entire memory cells can be discretely categorized by two groups: leaky cells or normal cells, and the main distribution representing the normal cells shows longer than 40 s of the mean retention time. The leaky cells are mainly originated by trap-assisted gate-induced drain leakage currents depending on trap energy dispersion. Through analyses of full chip retention failure curves and interface trap density ( Dit*) measurements, we propose that the tail distribution will be diminished and separated from the main distribution as the cell size shrinks into a true nanoscale. As a result, the retention time is eventually to be determined by the main distribution function only.
HIV infection is strongly associated with hip fracture risk, independently of age, gender, and comorbidities: A population‐based cohort study

HIV infection and antiretroviral therapies have detrimental effects on bone metabolism, but data on their impact on fracture risk are controversial. We conducted a population‐based cohort study to explore the association between clinical diagnosis of HIV infection and hip and major osteoporotic fracture risk. Data were obtained from the SIDIAPQ database, which contains clinical information for >2 million patients in Catalonia, Spain (30% of the population). We screened the database to identify participants with a clinical diagnosis of HIV infection, and ascertained incident hip and osteoporotic major fractures in the population aged 40 years or older in 2007 to 2009. In addition, data on incident fractures involving hospital admission were obtained from the Hospital Admissions database. Cox regression models were used to estimate hazard ratios (HRs) for the HIV‐infected versus uninfected participants. Models were adjusted for age, sex, body mass index, smoking status, alcohol drinking, oral glucocorticoid use, and comorbid conditions (Charlson index). Among 1,118,156 eligible participants, we identified 2489 (0.22%) subjects with a diagnosis of HIV/AIDS. Age‐ and sex‐adjusted HR for HIV/AIDS were 6.2 (95% confidence interval [CI] 3.5–10.9; p < 0.001) and 2.7 (2.01–3.5; p < 0.001) for hip and major fractures, respectively; this remained significant after adjustment for all mentioned potential confounders: HR 4.7 (2.4–9.5; p < 0.001) and 1.8 (1.2–2.5; p = 0.002). After stratifying by age, the association between HIV infection and major fractures was attenuated for those aged <59 years (adjusted HR 1.35 [0.88–2.07], p = 0.17) but appeared stronger in older patients (adjusted HR 2.11 [1.05–4.22], p = 0.035). We report a strong association between HIV infection and hip fracture incidence, with an almost fivefold increased risk in the HIV infected, independent of sex, age, smoking, alcohol drinking, and comorbidities. Similarly, we demonstrate a 75% higher risk of all clinical fractures and a 60% increase in risk of non‐hip clinical fractures among patients with a diagnosis of HIV infection.
Harmonic bundles on noncompact curves

The purpose of this paper is to extend the correspondence between Higgs bundles and local systems [2,5,6,7, 13, 17, 19,20,21] to the case when X is a noncom pact algebraic curve. The basic result is that there is a class of analytic objects on X which will be put in one-to-one correspondences with two different classes of algebraic geometric objects on the completion X. The analytic objects are harmonic bundles on X satisfying a growth condition at the punctures which we call tameness. The two types of algebraic objects are Higgs bundles and g-x-modules, both with regular singularities at the punctures, together with additional data of filtrations of the fibers over the punctures. The filtered regular g-x-modules also correspond to topological objects, local systems (i.e. representations of the fundamental group), together with filtrations assigned to the punctures. For the algebraic or topological objects, there is an
Genome Sequence of Acinetobacter calcoaceticus PHEA-2, Isolated from Industry Wastewater

ABSTRACT Genome analysis of Acinetobacter calcoaceticus PHEA-2 was undertaken because of the importance of this bacterium for bioremediation of phenol-polluted water and because of the close phylogenetic relationship of this species with the human pathogen Acinetobacter baumannii. To our knowledge, this is the first strain of A. calcoaceticus whose genome has been sequenced.
The SUCCESS project: the effect of program format and incentives on participation and cessation in worksite smoking cessation programs.

OBJECTIVES This study examined the effect of program format and incentives on participation and cessation in worksite smoking cessation programs. METHODS Twenty-four worksites were randomized to 6 conditions that differed in cessation program format and the use of incentives. Programs were offered for 18 months in each worksite. A total of 2402 cigarette smokers identified at baseline were surveyed 12 and 24 months later to assess participation in programs and cessation. RESULTS A total of 407 (16.9%) of the smoker cohort registered for programs; on the 12- and 24-month surveys, 15.4% and 19.4% of the cohort, respectively, reported that they had not smoked in the previous 7 days. Registration for programs in incentive sites was almost double that of no-incentive sites (22.4% vs 11.9%), but increased registration did not translate into significantly greater cessation rates. Program type did not affect registration or cessation rates. CONCLUSIONS Although incentives increase rates of registration in worksite smoking cessation programs, they do not appear to increase cessation rates. Phone counseling seems to be at least as effective as group programs for promoting smoking cessation in worksites.