Miracle-dz/UniFAR-FTUs huggingface dataset:
AGILE CONSTRUCTION PROJECT MANAGEMENT

Project management in the information systems industry has had a poor record of delivering value and has consequently seized upon the recent evolutional of agile project management. What is meant by agile project management, from whence it originated and whether it has further applicability are not widely understood. The construction industry also has a less than perfect project management record and might benefit from the adoption of agile project management. An extended literature review has established that agile project management does indeed offer significant improvements and that the construction industry might also potentially benefit. In order to resolve to an agile theory, the underlying rationales for agile have been explored, leading to the identification of further promising research
The Wechsler Test of Adult Reading as a Measure of Premorbid Intelligence Following Traumatic Brain Injury

Objective The current study sought to determine whether the Wechsler Test of Adult Reading (WTAR) provides a stable estimate of premorbid intellectual ability in acutely injured patients recovering from traumatic brain injury (TBI). Method A total of 135 participants (43 mild TBI [mTBI], 40 moderate/severe TBI [msevTBI], 52 healthy controls) were administered the WTAR at 1 and 12 months post-injury. Results Despite similar demographic profiles, participants with msevTBI performed significantly worse than controls on the WTAR at both time points. Moreover, the msevTBI group had a significant improvement in WTAR performance over the 1-year period. In contrast, those participants with mTBI did not significantly differ from healthy controls and both the mTBI and control groups demonstrated stability on the WTAR over time. Conclusions Results indicate that word-reading tests may underestimate premorbid intelligence during the immediate recovery period for patients with msevTBI. Clinicians should consider alternative estimation measures in this TBI subpopulation.
Multilingual Sentiment Analysis on Data of the Refugee Crisis in Europe

The refugee crisis in Europe was one of the biggest challenges in summer-autumn 2015. The problem drew the highest attention in media and was the discussion topic of politicians and responsible organizations. The current article presents multilingual sentiment analysis of the traditional media content covering the topic. Sentiment analysis forms an integral part of multifaceted media analysis. The dataset comprises relevant articles from eighty of the most circulated traditional media sources in English, German, Russian and Spanish, compiled in the course of three months. The temporal sentiment classification per language demonstrates how the attitude towards the crisis differs across the languages and geographical areas. The further sentiment analysis and visualizations of various aspects illustrate in details the distribution of positivity/negativity among media sources and their target languages. Keywords–Multilingual sentiment analysis; refugee crisis.
Psychometric Properties of the Benton Visual Form Discrimination Test

Coefficient alpha and an item analysis were calculated for the 16-item Benton Visual Form Discrimination Test (VFDT) using a heterogeneous sample (N = 293) of mostly elderly medical patients who were suspected of having cognitive impairment. The total score reliability was . 74. An item analysis found that 15 of the items were within established criteria for item difficulty, however, 5 items were found to be poor discriminators. Through the use of confidence intervals around observed scores, it was shown that the current classification criterion for the VFDT demands a higher reliability coefficient than what was found. Also, evidence for the test's insufficient level of difficulty is presented. It is difficult to recommend this test for clinical use.
Medicaid Payment Rates, Case-Mix Reimbursement, and Nursing Home Staffing—1996-2004

Objective:We examined the impact of state Medicaid payment rates and case-mix reimbursement on direct care staffing levels in US nursing homes. Methods:We used a recent time series of national nursing home data from the Online Survey Certification and Reporting system for 1996–2004, merged with annual state Medicaid payment rates and case-mix reimbursement information. A 5-category response measure of total staffing levels was defined according to expert recommended thresholds, and examined in a multinomial logistic regression model. Facility fixed-effects models were estimated separately for Registered Nurse (RN), Licensed Practical Nurse (LPN), and Certified Nurse Aide (CNA) staffing levels measured as average hours per resident day. Results:Higher Medicaid payment rates were associated with increases in total staffing levels to meet a higher recommended threshold. However, these gains in overall staffing were accompanied by a reduction of RN staffing and an increase in both LPN and CNA staffing levels. Under case-mix reimbursement, the likelihood of nursing homes achieving higher recommended staffing thresholds decreased, as did levels of professional staffing. Independent of the effects of state, market, and facility characteristics, there was a significant downward trend in RN staffing and an upward trend in both LPN and CNA staffing. Conclusions:Although overall staffing may increase in response to more generous Medicaid reimbursement, it may not translate into improvements in the skill mix of staff. Adjusting for reimbursement levels and resident acuity, total staffing has not increased after the implementation of case-mix reimbursement.
Customer language processing: Extended abstract

The research presented is the first working step towards the goal of developing a domain-independent method for sentiment analysis of German customer feedback in social media. The approach proposes to apply the concept of natural language processing (NLP) to customer language processing (CLP). In this context we hypothesize an indifference in annotator ability in assigning customer reviews of tangible vs. intangible goods and an indifferences within customers' writing styles within their evaluation of these goods. To test these hypotheses, a study was conducted where participants had to assign the sentiment as well as the subject of customer reviews and its evaluative attribute. The results reveal that the inter-rater reliability of annotators does not differ significantly with respect to product groups. However a slight difference with respect to product categories could be observed. Moreover, there occur variations within the inter-rater ability according to the emotional commitment towards products.
Raising take-up of social assistance benefits through a simple mailing: evidence from a French field experiment

This paper is related to the phenomenon puzzling unduly low take-up rate for social assistance benefits in France. In order to investigate this phenomenon, we conduct an experimental evaluation in the form of a randomized control trial involving the influences of informational availability and complexity. We examine the impact of a change in the information set which is sent to these households just after they claim the benefit, seeking a behavioral response to this particular ‘nudge’. Our findings suggest that a costless action on the part of program administrators is able to substantially increase take-up for certain types of beneficiaries. In order to be effective, these actions should target households according to their individual attributes.
SDS capillary gel electrophoresis of proteins in microfabricated channels.

Analysis of variations in the concentrations or structures of biomolecules (e.g., mRNAs, proteins, peptides, natural products) that occur either naturally or in response to environmental or genetic perturbations can provide important insight into complex biological processes. Many biological samples are mixtures that require a separation step before quantitation of variations in the individual components. Two-dimensional denaturing gel electrophoresis has been used very effectively to separate complex mixtures of proteins, but it is time consuming and requires considerable amounts of sample. Microchannel-based separations have proven very effective in rapidly separating small amounts of nucleic acids; more recently, isoelectric focusing of proteins also has been adapted to the microchannel format. Here, we describe microchannel-based SDS capillary gel electrophoresis of proteins and demonstrate the speed and high resolution it provides. This development is an important step toward the miniaturization and integration of multidimensional and array separation methods for complex protein mixtures.
Clonally Related CD8+ T Cells Responsible for Rapid Population of Both Diffuse Nasal-Associated Lymphoid Tissue and Lung After Respiratory Virus Infection

The immune system has evolved to use sophisticated mechanisms to recruit lymphocytes to sites of pathogen exposure. Trafficking pathways are precise. For example, lymphocytes that are primed by gut pathogens can, in some cases, be imprinted with CCR9 membrane receptors, which can influence migration to the small intestine. Currently, little is known about T cell trafficking to the upper respiratory tract or the relationship between effectors that migrate to the diffuse nasal-associated lymphoid tissue (d-NALT), the lower airways, and the lung. To determine whether a T cell primed by Ag from a respiratory pathogen is imprinted for exclusive trafficking to the upper or lower respiratory tract or whether descendents from that cell have the capacity to migrate to both sites, we inoculated mice by the intranasal route with Sendai virus and conducted single-cell–sequencing analyses of CD8+ T lymphocytes responsive to a Kb-restricted immunodominant peptide, FAPGNYPAL (Tet+). Cells from the d-NALT, lung airways (bronchoalveolar lavage), lung, and mediastinal lymph node were examined 10 d postinfection to determine TCR usage and clonal relationships. We discovered that 1) Tet+ cells were heterogeneous but preferentially used TCR elements TRAV6, TRAV16, and TRBD1; 2) both N and C termini of Vα and Vβ TCR junctions frequently encompassed charged residues, perhaps facilitating TCR αβ pairing and interactions with a neutral target peptide; and 3) T cells in the d-NALT were often clonally related to cells in the lower respiratory tract.
Blood–brain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons

We have evaluated the possibility that changes in the vascular system may constitute a contributing factor for the death of nigral dopaminergic neurons in Parkinson’s disease. Thus, we have employed intranigral injections of vascular endothelial growth factor (VEGF), the most potent inducer of blood–brain barrier (BBB) permeability. A single dose of 1 μg of VEGF, chosen from a dose‐response study, highly disrupted the BBB in the ventral mesencephalon in a time‐dependent manner. A strong regional correlation between BBB disruption and loss of tyrosine hydroxylase‐positive neurons was evident. Moreover, Fluoro‐Jade B labelling showed the presence of dying neurons in the substantia nigra in response to VEGF injection. High number of TUNEL‐positive nuclei was observed in this area along with activation of caspase 3 within nigral dopaminergic neurons. Analysis of the glial population demonstrated a strong inflammatory response and activation of astroglia in response to BBB disruption. We conclude that disruption of the BBB may be a causative factor for degeneration of nigral dopaminergic neurons.
Effect of Eicosapentaenoic Acid on the Different Endothelin System Components in Endothelin-1–Induced Hypertrophied Cardiomyocytes

The cardiovascular benefit of fish oil, including eicosapentaenoic acid (EPA), in humans and experimental animals has been reported. The role of endothelin-1 (ET-1) in cardiac hypertrophy is well known. Endothelin-1 stimulates prepro–ET-1 mRNA expression in cardiomyocytes, and the autocrine/paracrine system of ET-1 is important for cardiomyocyte hypertrophy. Although many studies link EPA to cardiac protection, the effect of EPA on cardiac hypertrophy has yet to be clarified. Recently, we demonstrated that ET-1–induced cardiomyocytic change could be prevented by pretreatment with EPA. The present study investigated the changes of different components of the ET system at the mRNA level in ET-1–administered cardiomyocytes, and examined the effect of EPA pretreatment. Ventricular cardiomyocytes were isolated from 2-day-old Sprague-Dawley rats, cultured in Dulbecco’s modified Eagle’s medium and Ham F12 supplemented with 0.1% fatty acid–free bovine serum albumin for 3 days. At Day 4 of culture, the cardiomyocytes were divided into 3 groups: control group, ET-1–treated (0.1 nM) group, and ET-1–treated group pretreated with EPA (10 μM). Twenty-four hours after treatment, the gene expressions of different components of the endothelin system in three experimental groups were evaluated by real-time polymerase chain reaction. Prepro–ET-1 mRNA expression was 53% upregulated in ET-1–induced hypertrophied cardiomyocytes and suppressed in the EPA-pretreated group. Endothelin-converting enzyme-1 (ECE-1) was also increased in ET-1–administered cardiomyocytes by 42% compared with the control group and was reversed in the EPA-pretreated group. The two receptors of ET system, ETA and ETB, tended to be increased in the ET-1–treated group, but no statistical significance was seen among study groups. Endothelin-1 increased prepro–ET-1 and ECE-1 mRNA expression in hypertrophied-neonatal cardiomyocytes, and this was reversed with EPA pretreatment. Thus, EPA may play a crucial role in the regression of ET-1–induced cardiomyocyte hypertrophy, partly through the suppression of ET-1 and ECE-1 expression.
Did International Outsourcing Cause the Increase in China's Skill Premium?

This study analyzes the transmission mechanism for the increase in the skill premium caused by international outsourcing through skill-biased technological change (SBTC). Using 2000–2013 panel data from 27 manufacturing industries in China, this study conducts both probit and Tobit tests and shows that international outsourcing led to SBTC in China's manufacturing industries. A positive correlation is found between international outsourcing and the increase in the skill premium in both static and dynamic models. For each 1-percent increase in the international outsourcing index, the skill premium will rise approximately 10 percent. This finding indicates the existence of a mechanism through which the effect of international outsourcing on the skill premium is reinforced where SBTC is occurring. However, this may enlarge wage gaps within the same industry. Therefore, China should not only use the skill premium to promote the transformation and upgrading of industries benefiting from outsourcing and optimize the structure of employment but also prevent the negative effects of an increased skill premium.
A methyltransferase required for proper timing of the vernalization response in Arabidopsis

Significance Proper timing of flowering is a key factor in reproductive success. Certain plant species require prolonged cold exposure during winter to flower in the spring; however, how plants measure the duration of cold exposure is not well understood. In this study, we describe the identification of a methyltransferase that is required for proper measurement of the duration of cold exposure. Prolonged exposure to winter cold enables flowering in many plant species through a process called vernalization. In Arabidopsis, vernalization results from the epigenetic silencing of the floral repressor FLOWERING LOCUS C (FLC) via a Polycomb Repressive Complex 2 (PRC2)-mediated increase in the density of the epigenetic silencing mark H3K27me3 at FLC chromatin. During cold exposure, a gene encoding a unique, cold-specific PRC2 component, VERNALIZATION INSENSITIVE 3 (VIN3), which is necessary for PRC2-mediated silencing of FLC, is induced. Here we show that SET DOMAIN GROUP 7 (SDG7) is required for proper timing of VIN3 induction and of the vernalization process. Loss of SDG7 results in a vernalization-hypersensitive phenotype, as well as more rapid cold-mediated up-regulation of VIN3. In the absence of cold, loss of SDG7 results in elevated levels of long noncoding RNAs, which are thought to participate in epigenetic repression of FLC. Furthermore, loss of SDG7 results in increased H3K27me3 deposition on FLC chromatin in the absence of cold exposure and enhanced H3K27me3 spreading during cold treatment. Thus, SDG7 is a negative regulator of vernalization, and loss of SDG7 creates a partially vernalized state without cold exposure.
Validation of 4β-hydroxycholesterol and evaluation of other endogenous biomarkers for the assessment of CYP3A activity in healthy subjects.

AIMS This study aimed to assess changes in the plasma concentrationss of 4β-hydroxycholesterol (4βHC) against intravenous (i.v.) and oral midazolam (MDZ) pharmacokinetics (PK) after administration of a potent CYP3A inhibitor [ketoconazole (KETO)] and inducer [rifampicin (RIF)]. METHODS Thirty-two healthy subjects (HS) were allocated into three groups of 12 each in KETO and RIF and 10 in a placebo group (PLB). All HS were randomized to receive oral and i.v. MDZ on day 1 or 2 and on day 15 or 16 after receiving RIF (600 mg once daily), KETO (400 mg once daily) or PLB for 2 weeks. Subjects were followed until day 30. The effect of treatments on 4βHC was assessed by analyzing % change from baseline using a linear spline mixed effects model. RESULTS Compared with PLB, KETO decreased 4βHC mean values up to 13% (P = 0.003) and RIF increased 4βHC mean values up to 220% (P < 0.001). Within 14 days of stopping KETO and RIF, 4βHC had either returned to baseline (KETO) or was still returning to baseline (RIF). Compared with baseline, mean oral MDZ AUC increased by 11-fold (90% CI ranging from 9-fold to 13-fold increase) and decreased by 92% (90% CI ranging from 90% to 95% decrease) after KETO and RIF, respectively. Similar trends were observed for 6β-hydroxycortisol : cortisol (6βHCL : CL) urinary ratios. CONCLUSIONS Changes in plasma 4βHC can be utilized as a surrogate for MDZ PK after multiple doses of potent CYP3A inducers. There is a more limited dynamic range for 4βHC for assessment of potential CYP3A inhibitors. 4βHC is a valuable tool for the assessment of potential CYP3A inducers in early drug development.
Antibody Repertoire Development in Fetal and Neonatal Piglets. VIII. Colonization Is Required for Newborn Piglets to Make Serum Antibodies to T-Dependent and Type 2 T-Independent Antigens1

Cesarean-derived piglets were reared for 5 wk under germfree conditions or monoassociated with a benign Escherichia coli (G58-1) or a enterohemorrhagic strain (933D) derived from O157:H7, and immunized i.p. with the T-dependent (TD) Ags fluorescein-labeled (FL) keyhole limpet hemocyanin or trinitrophenylated (TNP) keyhole limpet hemocyanin and the type 2 T-independent Ags TNP-Ficoll or FL-Ficoll. Only colonized piglets showed an increase in serum IgG, IgA, and IgM and had serum Abs to FL, TNP, and colonizing bacteria. While serum Abs to FL or TNP appeared following colonization alone, secondary responses were restricted to piglets immunized using TD carriers. While animals colonized with 933D had significantly higher total serum IgG and IgM levels and specific IgG Abs than those colonized with G58-1, no differences were seen in serum IgA levels, B cell diversification in the ileal Peyer’s patches, and specific activity (ELISA activity per micrograms of Ig) of pre-boost serum IgG and IgM anti-TNP and anti-FL Abs. Serum IgA Abs to TNP, FL, or bacteria were not detected. Ag-driven responses, as measured by an increase in specific Ab activity, were only observed in secondary responses to TD Ags and to colonizing, pathogenic E. coli. We propose that germline-encoded, isotype-switched B cells in newborn piglets differentiate to Ab-secreting cells 1) after stimulation by bacteria-activated APCs or 2) through direct stimulation by bacterial products. We further propose that Ag-driven systemic responses require both bacterial colonization and TD Ags translocated to the peritoneum.
Development of a National TMJ Implant Registry and Repository-- NIDCR's TIRR.

PURPOSE To provide a national systematic program to collect removed TMJ implants and biological tissues, make them available to researchers, and study them in conjunction with long-term clinical follow-up, with the ultimate goal of stimulating research toward understanding the safety and outcomes of TMJ implants. PROCESS Two synchronized divisions: The Registry, recruiting clinicians and/or surgeons and patients, and collecting comprehensive clinical patient data over time; the Repository, procuring and archiving high quality, well characterized biological specimens and retrieved implants for dissemination. PARTICIPATION Clinicians, surgeons, patients, researchers, pilot studies. PROGRESS October 2002-present: Recruited 34 TMJ surgeons, 34 TMJ clinicians; registered 723 surgical/non-surgical TMJD patients and control subjects; collected 542 specimens, blood, saliva; initiated 19 projects using TIRR resources; produced 60 publications and presentations nationally and internationally; sent ten grants into review, with more being developed. PROSPECTS/PROJECTIONS Continuing collection of long-term data for the development of new and improved implant designs and materials and investigation into understanding pathological mechanisms of TMJD.
NO EVIDENCE FOR PATIENT‐TO‐PATIENT TRANSMISSION OF HEPATITIS C VIRUS DURING UPPER GASTROINTESTINAL ENDOSCOPY: MOLECULAR STUDIES ON THREE ACUTE HEPATITIS C PATIENTS

Background: The risk of patient‐to‐patient transmission of hepatitis C virus (HCV) during endoscopy remains controversial. Using molecular approaches, we examined the possibility of patient‐to‐patient transmission of HCV in three patients who developed acute hepatitis C 1–6 months after examination by upper gastrointestinal endoscopy (UGIE) in a hospital endoscopy unit in Japan.
Exploiting contention and congestion aware switch allocation in network-on-chips

Network-on-chip system plays an important role to improve the performance of chip multiprocessor systems. As the complexity of the network increases, congestion problem has become the major performance bottleneck and seriously influence the performance of NoCs. Prior works have focused on designing effective routing algorithm based on collecting congestion and contention information to load balance the traffic. However, most prior works do not consider balancing the traffic load during switch allocation. Due to the lack of congestion information in switch allocation stage, switch allocator performs allocation only based on packet requests and thus aggravates the congestion in the ports of switch. In this paper, we propose to add the congestion and contention information into the switch allocation process and design an efficient on-chip switching strategy which utilizes the contention and congestion information to load balance the traffic and achieve efficient switch allocation. To further enhance the performance of our design, we carefully design our switch allocation strategy to balance the trade-off between traffic load balance and the matching efficiency in switch allocation. We evaluate our design under synthetic traffic and trace of parsec benchmarks. Our evaluations show this mechanism achieves optimal latency compared to best previous switch allocation strategies.