Miracle-dz/UniFAR-FTUs huggingface dataset:
Kalman Filter-Based Indoor Position Tracking with Self-Calibration for RSS Variation Mitigation

This paper investigates the indoor position tracking problem under the variation of received signal strength (RSS) characteristic from the changes of device statuses and environmental factors. A novel indoor position tracking algorithm is introduced to provide reliable position estimates by integrating motion sensor-based positioning (i.e., dead-reckoning) and RSS-based fingerprinting positioning with Kalman filter. In the presence of the RSS variation, RSS-based fingerprinting positioning provides unreliable results due to different characteristics of RSS measurements in the offline and online phases, and the tracking performance is degraded. To mitigate the effect of the RSS variation, a recursive least square estimation-based self-calibration algorithm is proposed that estimates the RSS variation parameters and provides the mapping between the offline and online RSS measurements. By combining the Kalman filter-based tracking algorithm with the self-calibration, the proposed algorithm can achieve higher tracking accuracy even in severe RSS variation conditions. Through extensive computer simulations, we have shown that the proposed algorithm outperforms other position tracking algorithms without self-calibration.
Spindle Formation and Dynamics of γ-Tubulin and Nuclear Mitotic Apparatus Protein Distribution During Meiosis in Pig and Mouse Oocytes1

Abstract This work focuses on the assembly and transformation of the spindle during the progression through the meiotic cell cycle. For this purpose, immunofluorescent confocal microscopy was used in comparative studies to determine the spatial distribution of α- and γ-tubulin and nuclear mitotic apparatus protein (NuMA) from late G2 to the end of M phase in both meiosis and mitosis. In pig endothelial cells, consistent with previous reports, γ-tubulin was localized at the centrosomes in both interphase and M phase, and NuMA was localized in the interphase nucleus and at mitotic spindle poles. During meiotic progression in pig oocytes, γ-tubulin and NuMA were initially detected in a uniform distribution across the nucleus. In early diakinesis and just before germinal vesicle breakdown, microtubules were first detected around the periphery of the germinal vesicle and cell cortex. At late diakinesis, a mass of multi-arrayed microtubules was formed around chromosomes. In parallel, NuMA localization changed from an amorphous to a highly aggregated form in the vicinity of the chromosomes, but γ-tubulin localization remained in an amorphous form surrounding the chromosomes. Then the NuMA foci moved away from the condensed chromosomes and aligned at both poles of a barrel-shaped metaphase I spindle while γ-tubulin was localized along the spindle microtubules, suggesting that pig meiotic spindle poles are formed by the bundling of microtubules at the minus ends by NuMA. Interestingly, in mouse oocytes, the meiotic spindle pole was composed of several γ-tubulin foci rather than NuMA. Further, nocodazole, an inhibitor of microtubule polymerization, induced disappearance of the pole staining of NuMA in pig metaphase II oocytes, whereas the mouse meiotic spindle pole has been reported to be resistant to the treatment. These results suggest that the nature of the meiotic spindle differs between species. The axis of the pig meiotic spindle rotated from a perpendicular to a parallel position relative to the cell surface during telophase I. Further, in contrast to the stable localization of NuMA and γ-tubulin at the spindle poles in mitosis, NuMA and γ-tubulin became relocalized to the spindle midzone during anaphase I and telophase I in pig oocytes. We postulate that in the centrosome-free meiotic spindle, NuMA aggregates the spindle microtubules at the midzone during anaphase and telophase and that the polarity of meiotic spindle microtubules might become inverted during spindle elongation.
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

AutoDock Vina, a new program for molecular docking and virtual screening, is presented. AutoDock Vina achieves an approximately two orders of magnitude speed‐up compared with the molecular docking software previously developed in our lab (AutoDock 4), while also significantly improving the accuracy of the binding mode predictions, judging by our tests on the training set used in AutoDock 4 development. Further speed‐up is achieved from parallelism, by using multithreading on multicore machines. AutoDock Vina automatically calculates the grid maps and clusters the results in a way transparent to the user. © 2009 Wiley Periodicals, Inc. J Comput Chem 2010
Primary health care nurses’ management practices of common mental health conditions in KwaZulu-Natal, South Africa

Background Psychiatric conditions contribute to 13% of the global burden of diseases and account for one third of years lost because of disability (YLD). Despite the high prevalence of mental health problems, primary health care (PHC) services remain ineffective in managing patients with mental health conditions. Objectives The aim of the study was to determine the practices of PHC nurses in the management of psychiatric patients in primary health care clinics in one of the rural districts in South Africa. Method A survey was conducted amongst nurses working in several PHC clinics in KwaZulu-Natal (KZN) in order to determine their practices in the management of psychiatric patients. Mixed methods were used to determine the PHC nurses practices in the management of psychiatric patients. Results The findings revealed that in five sites (83.3%) treatments are not reviewed every six months, there were no local protocols on the administration of psychiatric emergency drugs, and none of the study sites provided psychiatric patients with education on their medication and its possible side effects. Conclusion Based on the results of this study it is evident that psychiatric patients at PHC clinics in the district where the study was conducted do not receive quality treatment according to institutional mental health guidelines.
The Effects of Moving Animation on Recall, Hedonic and Utilitarian Perceptions, and Attitude

An increasing number of firms are investing in moving animation to create more vivid and attractive Web sites. Animated contents are usually invisible to search engines or Web spiders, involve lengthier download time, and are inaccessible to less technology-savvy users who are not equipped with the necessary software or browser plug-ins or users who are wary of malicious Internet downloads. The development costs of animated Web sites are considerably higher too compared with static Web sites. Do the benefits provided by animation justify all of these potential weaknesses? We answer this question by studying the effects of moving animation on consumer responses toward a product. Using an exploratory laboratory experiment, we found that moving animation enhances product recall, perceived product values in terms of the hedonic and utilitarian dimensions, and attitude toward products that are high on the hedonic dimension. It does not, however, enhance consumer attitude toward products that are more ldquoutilitarianrdquo in nature. We draw related managerial implications from these findings.
Scene Structure Inference through Scene Map Estimation

Understanding indoor scene structure from a single RGB image is useful for a wide variety of applications ranging from the editing of scenes to the mining of statistics about space utilization. Most efforts in scene understanding focus on extraction of either dense information such as pixel-level depth or semantic labels, or very sparse information such as bounding boxes obtained through object detection. In this paper we propose the concept of a scene map, a coarse scene representation, which describes the locations of the objects present in the scene from a top-down view (i.e., as they are positioned on the floor), as well as a pipeline to extract such a map from a single RGB image. To this end, we use a synthetic rendering pipeline, which supplies an adapted CNN with virtually unlimited training data. We quantitatively evaluate our results, showing that we clearly outperform a dense baseline approach, and argue that scene maps provide a useful representation for abstract indoor scene understanding.
Processes for improved human control over definition of product models

Engineering requires vast amount of highly related information about products, production environments, application environments, etc. at development, production, application, and recycling of products in advanced computer systems. During lifecycle of product, engineers and other humans have influence on product information according to their role within a project team or outside of it. Short innovation cycles, complex mechatronical products, high distances, and high number of product variants often make really efficient contribution of engineers impossible at the application of large product models. In order to avoid this situation, product model must work in the absence of the engineers who developed them. In other words, product model must represent intent of more or less engineers. Current product models have not this capability. The authors recognized the related task as establishment a new product model that organizes background of model object definitions. According to their proposal, this model completes the currently prevailing information based product models where engineering objects are described by their related attributes. In this paper, a method is introduced that use design intent based engineering objectives and context representations at decision on engineering objects and their attributes in information based product model.
Local altruistic coalition formation game for spectrum sharing and interference management in hyper-dense cloud-RANs

In this study, the authors investigate the spectrum sharing and interference management in hyper-dense cloud radio access networks (C-RANs). The authors formulate this problem as a local altruistic coalition formation game (LACF) with externalities. Different from previous studies considering maximising individual small cell's throughput, the authors’ purpose is to maximise the social welfare, i.e. the sum satisfaction of remote radio heads (RRHs) with diverse traffic types. The authors design a local altruistic utility function for RRH, i.e. each RRH cares about not only his own interest but also his neighbours’. They make autonomous decisions, finally shaping the entire RRHs into multiple disjoint coalitions. In addition, joint transmission coordinated multi-point technology is considered within coalition to mitigate interference. Then, the authors propose a distributed coalitional formation algorithm based on modified recursive core to obtain the final stable coalition partition. Furthermore, the system stability, convergence and complexity of the proposed algorithm are analysed. Numerical results show that the proposed algorithm outperforms the classical and non-cooperation schemes in the perspective of both social welfare and individual fairness. To be specific, the average rate per RRH of the authors’ proposed scheme is superior to the classical and non-cooperation cases by 20 and 25% in hyper-dense scenario, respectively.
Promjene u Programu obveznih cijepljenja u Republici Hrvatskoj u 2008. godini

Profesionalni epidemioloski tim trajno educiran u podrucju izrade i evaluacije programa masovnog cijepljenja u Službi za epidemiologiju zaraznih bolesti Hrvatskog zavoda za javno zdravstvo Zakonom o zastiti pucanstva od zaraznih bolesti (NN 79/2007) predlaže Program masovnog cijepljenja u Hrvatskoj Ministru zdravstva i socijalne skrbi. Potpisom Ministra Program prerasta u dokument koji obvezuje državu i Hrvatski zavod za zdravstveno osiguranje da osiguraju financijska sredstva za provođenje Programa, te zdravstvene ustanove i privatne lijecnike da provode Program cijepljenja.
An instrumented valved holding chamber with facemask to measure application forces and flow in young asthmatic children.

BACKGROUND Pressurized metered dose inhalers (pMDIs), combined with a valved holding chamber (VHC) and facemask, are often used for young asthmatic children. When using a VHC with facemask, a tight seal between the facemask and the patient's face is crucial for efficient pulmonary aerosol delivery. Realistic parameters for in vitro bench testing are not well known. A custom instrumented OptiChamber Diamond VHC, known as the Facemask Datalogger, was developed to measure the real-time application of force and the air flow through the VHC and facemask. METHODS Thirty asthmatic children aged 1-4 years from the Kinderhaven outpatient clinic, who were prescribed a pMDI/VHC with facemask for regular use, were included in the study. Using the Facemask Datalogger, the parent applied the facemask to the face of the child during normal tidal breathing, and force and flow were recorded. This was repeated three times. A video of the procedure was made and scored on cooperation (scale of 1-5). RESULTS Mean application force was 4 N (± 1.5) equal to 411 g (± 156) when expressed as a weight equivalent; intrasubject variability in application force was 23% (± 23); intersubject variability in application force was 39%; time needed to empty the VHC was 4.5 sec (± 2.9); breaths needed to empty the VHC were 2.9 (± 1.1); and mean cooperation score was 4.3 (± 0.8). Age was correlated with time (r=-0.49; p=0.006) and breaths needed to empty the VHC (r=-0.75; p<0.001), and observer cooperation score (r=0.65; p<0.001). CONCLUSIONS The Facemask Datalogger is useful for measuring application force and air flow in vivo. Mean application force was lower than assumed in other studies. Older children emptied the VHC faster, with fewer breaths and better cooperation. The data from this study can be used in the future development and testing of new facemasks and VHCs.
In vitro Analysis of the Impact of Enrofloxacin Residues on the Human Intestinal Microbiota Using 1H-NMR Spectroscopy

Exposure of humans to antimicrobial residues in food-producing animals may alter the intestinal microbiota which could result in a potential risk to human health. To determine the effect of enrofloxacin on the human intestinal microbiota, fecal suspensions (25%) were cultured in the presence of 0.06–5 µg/ml enrofloxacin. The bacterial community was analyzed by plating on selective culture media, pyrosequencing and nuclear magnetic resonance (NMR) spectroscopy. Pyrosequencing analysis of 16S rRNA genes and viable counts on Bacteroides sp. , Enterococcus sp. , and Bifidobacterium sp. selection medium indicated that there were no significant changes in the bacteria numbers at the selected enrofloxacin concentrations (0.06, 0.1, and 1 µg/ml) relative to the control samples after a 48 h incubation. NMR analysis showed remarkably similar spectra in cultures treated with 0.06, 0.1, and 1 µg/ml enrofloxacin, with some slight differences in peak heights. However, hierarchical clustering analysis indicated significant differences in metabolite concentrations between the control and those samples treated with 1 µg/ml enrofloxacin. Leucine, phenylalanine, proline, and 2-oxovalerate were positively correlated with the concentration of enrofloxacin. NMR analysis is a potentially useful tool to monitor changes of the human intestinal microbiota, in addition to traditional culture methods and pyrosequencing.
The efficacy of integrating spirituality into undergraduate nursing curricula

Background: Attention to patients’ spirituality, as a moral obligation of care, is now widely accepted in nursing practice. However, until recently, many nursing programs have paid little attention to spirituality. Objective: The objective of this study was to identify the impact of two different curricula, used to teach undergraduate nursing students, on increasing nursing student awareness of spirituality in the care of patients. Research design: A quasi-experimental post-intervention two-group design was conducted in 2009–2010 and 2010–2011 academic years. Participants and research context: The study included a total of 130 volunteer senior-year students. The students were assigned as “the intervention group/integrated system” that were informed about spirituality or as “the control group/traditional system” that received no information on spirituality. Data were collected via a personal information form and the Spirituality and Spiritual Care Rating Scale was used to assess responses. The study was conducted at the Department of Nursing of the Faculty of Health Sciences, Cumhuriyet University, in Central Anatolia/Turkey. Ethical considerations: Permission to conduct the study at the nursing school was obtained from the schools’ management teams. The rights of the participants were protected in this study by obtaining informed consent. Findings: The results revealed that the intervention group had a higher mean score on the Spirituality and Spiritual Care Rating Scale than did the control group. The students in the intervention group defined the terms of spirituality and spiritual care more accurately than did the control group students. Discussion: Nurses are professionally and ethically responsible for providing spiritual care. Nurses’ competence in meeting the spiritual needs of their patients should be improved by undergraduate education on spiritual care. Nursing scholars reported a significant difference in the knowledge and attitudes toward spirituality of nursing students as a result of the integration of spirituality into the undergraduate nursing curriculum. Conclusion: Spirituality should be more widely included in nursing education.
Intracranial recordings reveal transient response dynamics during information maintenance in human cerebral cortex

Despite an extensive body of work, it is still not clear how short term maintenance of information is implemented in the human brain. Most prior research has focused on “working memory”—typically involving the storage of a number of items, requiring the use of a phonological loop and focused attention during the delay period between encoding and retrieval. These studies largely support a model of enhanced activity in the delay interval as the central mechanism underlying working memory. However, multi‐item working memory constitutes only a subset of storage phenomena that may occur during daily life. A common task in naturalistic situations is short term memory of a single item—for example, blindly reaching to a previously placed cup of coffee. Little is known about such single‐item, effortless, storage in the human brain. Here, we examined the dynamics of brain responses during a single‐item maintenance task, using intracranial recordings implanted for clinical purpose in patients (ECoG). Our results reveal that active electrodes were dominated by transient short latency visual and motor responses, reflected in broadband high frequency power increases in occipito‐temporal, frontal, and parietal cortex. Only a very small set of electrodes showed activity during the early part of the delay period. Interestingly, no cortical site displayed a significant activation lasting to the response time. These results suggest that single item encoding is characterized by transient high frequency ECoG responses, while the maintenance of information during the delay period may be mediated by mechanisms necessitating only low‐levels of neuronal activations. Hum Brain Mapp 36:3988–4003, 2015. © 2015 Wiley Periodicals, Inc.
Strategy-focused product innovation with product scorecard and product innovation scorecard

This paper shows how strategy-focused product innovation can be done with a product scorecard and a product innovation scorecard. A product scorecard is a performance measurement system that allows the product managers to view the product performances from several perspectives simultaneously. A product innovation scorecard is a performance measurement system that allows the product innovators to view the product innovation from several perspectives. A product scorecard and a product innovation scorecard like a balanced scorecard is not a list of measures; it is a description of the product strategy and product innovation strategy respectively. Both the scorecards start with a description of the strategy by the strategy map of balanced scorecard. The uses of a product and product innovation scorecards are evaluation, adoption, positioning, life-cycle management, growth management and more for a product and a product innovation respectively. A product scorecard is used to create the new requirements of a product innovation according to the financial goals or the mission whichever is appropriate. A product innovation scorecard is used to measure the performance of the product innovation during the continuous product innovation process by the product innovators.
Pharmacodynamics of antimicrobials: treatment optimisation

As bacterial resistance continues to increase, optimising the potential for successful clinical outcomes with antimicrobial therapy requires consideration of pharmacodynamic concepts in order to maximise bacterial eradication and minimise the potential for further resistance. Based on the pharmacodynamic characteristics of specific antibiotics, dosage modifications can be implemented to improve the likelihood of bactericidal exposure. Considering their concentration-dependent bactericidal activity, aminoglycosides benefit from increased dosages and infrequent administration, so as to achieve a maximum concentration/minimum inhibitory concentration (MIC) of 10 – 12. In contrast, β-lactams are concentration-independent killers and benefit greatest by increasing the time above the MIC (T > MIC). This can be accomplished with the use of prolonged or continuous infusion. By optimising pharmacodynamic parameters with these methodologies, successful treatment of pathogens may be possible in patient populations for whom standard dosing regimens are not effective.
OntoBiotope: une ontologie pour croiser les habitats microbiens avec les analyses de génomes.

L'evolution des technologies et des methodes d'analyse nous permet desormais d'aborder des environnements complexes comme les ecosystemes microbiens: aliment, tube digestif, animal, traitement des eaux usees, sol, ocean, etc., et la generalisation de ces approches metagenomiques a grande echelle delivre une enorme quantite d'information en terme d'especes de microorganismes identifiees dans les environnements etudies. Il est alors envisageable de considerer globalement les proprietes des ecosystemes dans lesquels vivent ces microorganismes, ainsi que les interactions et les associations qu'ils developpent avec leur environnement et entre eux-memes. Cependant, le croisement systematique des especes microbiennes et de leurs habitats pour trouver des correlations significatives avec phylogenies, fonctions connues, contenus en genes ou autre se heurte a une difficulte majeure : les habitats microbiens sont decrits sous des formes tres variables dans le texte des publications scientifiques ou des bases de donnees genomiques de reference comme GenBank, GOLD (Genomes Online Database) ou SRA (Sequence Read Archive). Le projet OntoBiotope a developpe des methodes et des outils d'analyse automatisee pour exploiter ces ressources et d’en extraire des relations entre organismes et milieux. Ainsi, OntoBiotope devrait permettre d'apprehender plus finement le role des caracteristiques des milieux sur l'evolution des microorganismes et leurs proprietes physiologiques.