Miracle-dz/UniFAR-FTUs huggingface dataset:
Dictyostelium Sun‐1 Connects the Centrosome to Chromatin and Ensures Genome Stability

The centrosome‐nucleus attachment is a prerequisite for faithful chromosome segregation during mitosis. We addressed the function of the nuclear envelope (NE) protein Sun‐1 in centrosome‐nucleus connection and the maintenance of genome stability in Dictyostelium discoideum. We provide evidence that Sun‐1 requires direct chromatin binding for its inner nuclear membrane targeting. Truncation of the cryptic N‐terminal chromatin‐binding domain of Sun‐1 induces dramatic separation of the inner from the outer nuclear membrane and deformations in nuclear morphology, which are also observed using a Sun‐1 RNAi construct. Thus, chromatin binding of Sun‐1 defines the integrity of the nuclear architecture. In addition to its role as a NE scaffold, we find that abrogation of the chromatin binding of Sun‐1 dissociates the centrosome‐nucleus connection, demonstrating that Sun‐1 provides an essential link between the chromatin and the centrosome. Moreover, loss of the centrosome‐nucleus connection causes severe centrosome hyperamplification and defective spindle formation, which enhances aneuploidy and cell death significantly. We highlight an important new aspect for Sun‐1 in coupling the centrosome and nuclear division during mitosis to ensure faithful chromosome segregation.
Role of the renin‐angiotensin system in hepatic ischemia reperfusion injury in rats

It has been shown that the renin‐angiotensin system (RAS) plays key roles in the development of fibrosis in numerous organs, including the liver. Other studies have suggested that the RAS also may play roles in diseases of chronic inflammation. However, whether the RAS also can mediate acute inflammation in liver is unclear. The purpose of this study therefore was to determine the effect of the RAS inhibitors captopril and losartan on acute liver damage and inflammation caused by hepatic ischemia and subsequent reperfusion. Accordingly, male rats were subjected to 1 hour of hepatic ischemia (70%) followed by reperfusion; animals were killed 3, 8, or 24 hours after reperfusion. The effect of captopril or losartan (100 or 5 mg/kg intragastrically, respectively) was compared with that of vehicle (saline). The expression of angiotensinogen in liver increased fivefold 3 hours after reperfusion. Indices of liver damage and inflammation (e.g., alanine aminotransferase levels, pathological features, tumor necrosis factor‐α levels, and intercellular adhesion molecule‐1 expression) all were significantly elevated in vehicle‐treated animals after hepatic ischemia and subsequent reperfusion. Ischemia and reperfusion also caused an increase in the accumulation of protein adducts of 4‐hydroxynonenal, an index of oxidative stress. Captopril or losartan treatment showed profound protective effects under these conditions, significantly blunting the increase in all these parameters caused by ischemia and reperfusion. In conclusion, RAS inhibitors prevent acute liver injury in a model of inflammation caused by ischemia and reperfusion. These data further suggest that the RAS may play a key role in mediating such responses in the liver and suggest a novel role for this system. (HEPATOLOGY 2004;40:583–589.)
The Screening of Bio-flocculant -producing Bacteria and the Study of its Optimized Culture Conditions and Characteristics of the Bio-flocculant

A strain named n-3 was isolated for its flocculating efficiency could achieve 84.86% from the domestic wastewater of Urtmqi City. The strain was identified as Pseudomonas fragi based on its morphological and 16SrDNA sequence analysis. This study showed that the optimum pH and the optimum temperature for producing bio-flocculants were 7.0 and 30°C respectively.
Delayed Feedback Controller for damping Subsynchronous oscillations in power systems

This paper presents a novel controller based on the delayed feedback control theory for stabilizing unstable torsional oscillations caused by Subsynchronous Resonance (SSR) in power systems. The first system of the IEEE Second Benchmark Model which consists of a synchronous generator connected to an infinite busbar through two parallel transmission lines, one of which is equipped with a series capacitor, is used to evaluate the controller's effectiveness. Dynamics of the generator damper windings and the Automatic Voltage Regulator (AVR) are included in the nonlinear model. The controller uses the synchronous generator rotor angular speed as the only input. The difference between the input signal's value τ-time in the past and its current value is multiplied with a gain to obtain the controller output, which is then combined into the AVR as the stabilizing signal. The effectiveness of the proposed controller in damping the torsional oscillations is demonstrated via time-domain simulations in MATLAB-Simulink. The optimum values of the controller parameters for various series compensation levels are also investigated.
Financial and non-financial reporting in Romanian entities operating in agriculture, forestry, and fishery

Due to the increased interest for sustainability issues, entities that operate in the areas agriculture, forestry and fishery are exposed to a variety of ecological challenges. Moreover, such fields are generally of strategic importance for a countrys economy, which also increases their exposure to public debate. The present study aims to provide a detailed and accurate description of the financial and non-financial information made available by listed Romanian entities operating in agriculture, forestry and fishery. The research goes beyond the mere description of the content of shareholders reports. Its purpose is to assess the financial performance and stability of selected companies and to investigate the relationships between the financial well-being of such companies and the extent to which they disclose non-financial information. The sample consists of companies which operate in the business of fields agriculture, forestry or fishery and are listed at the Bucharest Stock Exchange in Romania.
Measurements of Electrophysiological Effects of Components of Acute Ischemia in Langendorff‐Perfused Rat Hearts Using Voltage‐Sensitive Dye Mapping

Introduction: This study was carried out to evaluate optical mapping in the presence of cytochalasin‐D as a method for measuring electrophysiological responses in general, and in particular the responses to acute ischemia in the Langendorff‐perfused rat heart. Cytochalasin‐D is commonly used to reduce contraction for the purpose of suppressing motion artifacts in voltage‐sensitive dye recordings of cardiac membrane potential.
Large Cliques Elude the Metropolis Process

In a random graph on n vertices, the maximum clique is likely to be of size very close to 2 lg n. However, the clique produced by applying the naive “greedy” heuristic to a random graph is unlikely to have size much exceeding lg n. The factor of two separating these estimates motivates the search for more effective heuristics. This article analyzes a heuristic search strategy, the Metropolis process, which is just one step above the greedy one in its level of sophistication. It is shown that the Metropolis process takes super-polynomial time to locate a clique that is only slightly bigger than that produced by the greedy heuristic.
Predicting the size of a double-lumen endobronchial tube using computed tomographic scan measurements of the left main bronchus diameter.

UNLABELLED We investigated the use of chest computer tomographic (CT) scan measurement of the left mainstem bronchial diameter to predict the correct left-sided double-lumen endobronchial tube (DLT) size in Asian patients who may require smaller DLT sizes. Fifty consecutive Asian adults aged 17-80 yr with preoperative chest CT scans undergoing elective thoracic surgery were entered into the study. The measurements of the left main bronchus diameter were made by using the electronic calipers of the spiral scanner to the nearest millimeter. The sizes of DLT selected were 32F, 35F, 37F, 39F, and 41F for left main bronchus diameters of <10 mm, 10 mm, 11 mm, 12 mm, and >12 mm, respectively. All DLT placements were confirmed and positioned by using fiberoptic bronchoscopy. The tracheas of all patients were successfully intubated with the predicted DLT sizes. Thirty-four patients (68%) were predicted to require smaller DLTs (37F or smaller). Six patients were correctly predicted to receive 32F DLTs. Twelve patients (24%) received an oversized DLT, but none received an undersized DLT. The overall positive predictive value for the male and female patients was 84.4% and 61.1%, respectively. Our study showed that CT scan measurements of the diameter of the left bronchus were especially useful in choosing smaller DLTs. IMPLICATIONS We used computer tomographic scans to measure the diameter of the left mainstem bronchus, then selected the size of the left-sided double-lumen endobronchial tube (DLT) accordingly. We found that we could predict the sizes of the DLT fairly accurately, especially the smaller DLTs.
Incorporating “sinuous connectivity” into stochastic models of crustal heterogeneity: Examples from the Lewisian gneiss complex, Scotland, the Franciscan formation, California, and the Hafafit Gneiss Complex, Egypt

Stochastic models are valuable and sometimes essential tools for investigating the behavior of complex phenomena. In seismology, stochastic models can be used to describe velocity heterogeneities that are too small or too numerous to be described deterministically. Where analytic approaches are often infeasible, synthetic realizations of such models can be used in conjunction with finite difference algorithms to systematically investigate the response of the seismic wave field to complex heterogeneity. This paper represents a continuing effort at formulating a complete and robust stochastic model of lithologic heterogeneity within the crust, and the means of generating synthetic realizations; “complete” implies that the model is flexible enough to describe all types of random heterogeneity within the crust, while “robust” implies sufficiently constrained parameterization that an inversion problem may be well-posed. As a basis for investigation we use geologic maps of crustal exposures and petrophysically inferred velocities. Earlier efforts at stochastic modeling have focused on characterization of the univariate probability density function, which is typically modal (i.e., binary, ternary, etc.), and the covariance function, which is typically fit with a von Karman function. Here we provide a means of characterizing the property of “sinuous connectivity” and for generating realizations that possess this property. Sinuous connectivity is the tendency for individual lithologic units to be continuous over long and highly contorted paths; there is no means in the earlier modeling of either characterizing or synthesizing this property. We generate sinuously connective realizations by mapping regions encompassed by two contours in a Gaussian-distributed surface into the two values of the binary field. This operation is nonunique, as one can choose, in many ways, the values for the contours.
Binary hash tree based certificate access management for connected vehicles

We present a certificate access management system to support the USDOT's proposed rule on Vehicle-to-Vehicle (V2V) communications, Federal Motor Vehicle Safety Standard (FMVSS) No. 150. Our proposal, which we call Binary Hash Tree based Certificate Access Management (BCAM) eliminates the need for vehicles to have bidirectional connectivity with the Security Credential Management System (SCMS) for certificate update. BCAM significantly improves the ability of the SCMS to manage large-scale software and/or hardware compromise events. Vehicles are provisioned at the start of their lifetime with all the certificates they will need. However, certificates and corresponding private key reconstruction values are provided to the vehicle encrypted, and the keys to decrypt them are only made available to the vehicles shortly before the start of the validity periods of those certificates. Vehicles that are compromised can be effectively removed from the V2V system by preventing them from decrypting the certificates. We demonstrate that the system is feasible with a broadcast channel for decryption keys and other revocation information, even if that channel has a relatively low capacity. Reproducibility VM download link: https://drive.google. com/open? id=0B4ozf__jZFRs7VmhqampHczhBTkU
Ligand binding induces a conformational change in epidermal growth factor receptor dimers

The activation of the epidermal growth factor receptor (EGFR) kinase requires ligand binding to the extracellular domain (ECD). Previous reports demonstrate that the EGFR-ECD can be crystallized in two conformations – a tethered monomer or, in the presence of ligand, an untethered back-to-back dimer. We use Biosensor analysis to demonstrate that even in the monomeric state different C-terminal extensions of both truncated (EGFR1–501)-ECD and full-length EGFR1–621-ECD can change the conformation of the ligand-binding site. The binding of a monoclonal antibody mAb806, which recognizes the dimer interface, to the truncated EGFR1–501-Fc fusion protein is reduced in the presence of ligand, consistent with a change in conformation. On the cell surface, the presence of erythroblastosis B2 (erbB2) increases the binding of mAb806 to the EGFR. The conformation of the erbB2: EGFR heterodimer interface changes when the cells are treated with epidermal growth factor (EGF). We propose that ligand induces kinase-inactive, pre-formed EGFR dimers and heterodimers to change conformation leading to kinase-active tetramers, where kinase activation occurs via an asymmetric interaction between EGFR dimers.
Green IT/IS investments evaluation within the aviation industry: A focus on indirect cost management

Purpose The purpose of this paper is to utilize the existing theories and knowledge surrounding information systems (IS) evaluation and Green information technology (IT)/IS investments to develop a conceptual model for helping decision makers to overcome and reduce the impacts from Green IT/IS investment related to cost overruns or under-optimized budgets. Design/methodology/approach The paper is discursive, based on the analysis and synthesis of literature pertaining to IS evaluation, Green IT/IS adoption and Sustainable/Green/CSR within an aviation context. Gaps in the preceding research have been identified, and a conceptual model is proposed. Additionally, further research and a methodology are suggested. Findings The paper proposes a conceptual model that can identify factors including external factors derived from institutional theory, internal organizational factors, and a list of indirect costs associated with Green IT/IS investments for an aviation organization. Research limitations/implications As a conceptual paper, the study is limited to literature, identifying gaps, and proposing a model. The paper recommends further empirical validation of the proposed conceptual model. Practical implications The conceptual model is helpful for decision makers within the aviation industry to enhance their understanding of the identification and management of indirect costs within the aviation context, which results in effective management of Green IT/IS indirect costs. Originality/value The paper fills gaps in the knowledge of IS evaluation, Green IT/IS adoption/evaluation within aviation context through helping decision makers to understand, identify, and manage the associated indirect costs.
A DEA model for two-stage parallel-series production processes

Data envelopment analysis (DEA) has been widely used to measure the performance of the operational units that convert multiple inputs into multiple outputs. In many real world scenarios, there are systems that have a two-stage network process with shared inputs used in both stages of productions. In this paper, the problem of evaluating the efficiency of a set of specialized and interdependent components that make up a large DMU is considered. In these processes the first stage consists of two parallel components which are connected serially with the process in the second stage. The paper develops a DEA approach for measuring efficiency of decision processes which can be divided into two stages. This application of parallel-series production process involves shared resources and the paper determines an optimal split of shared resources among two components.
Cellular retinoid-binding proteins: limited proteolysis reveals a conformational change upon ligand binding.

Intracellular retinoid-binding proteins are small, tightly folded, compact proteins, which appear to be involved in the delivery of retinoids to microsomal metabolic enzymes, among other potential roles. Recently, it has been demonstrated that two of these binding proteins, cellular retinol-binding protein (CRBP) and cellular retinol-binding protein type II [CRBP(II)], interact with the same microsomal enzyme but in different manners, depending on the absence or presence of ligand [Herr, F.M. , & Ong, D.E. (1992) Biochemistry 31, 6748-6755]. The structural components of the binding proteins responsible for these differential interactions are presently unknown. In addition, it is not clear how the ligand is able to gain entry into the solvent-inaccessible interior binding cavity. Limited proteolysis of the apo and holo forms of CRBP and CRBP(II) was used to probe the conformational differences between the different states of these two proteins in solution. It was found that the apo forms of both proteins were significantly more susceptible to proteolysis, and probably adopted a more open conformation, than the holo forms. The initial cleavage site of endoproteinase Arg-C in the apo forms occurred at a conserved arginine residue near a possible site of ligand entry. Similar results were obtained by limited proteolysis of cellular retinoic acid-binding protein and heart fatty acid-binding protein, indicating that a common ligand-induced conformational change may occur for other members of this family of intracellular binding proteins. (ABSTRACT TRUNCATED AT 250 WORDS)
Optimal reducer placement to minimize data transfer in MapReduce-style processing

MapReduce-style processing has become the standard for large-scale distributed platforms, with Hadoop being the most popular implementation. While Hadoop achieves parallelism by scheduling Map and Reduce tasks across the available nodes, it incurs communication overhead in the Shuffle stage which sends intermediate results from mappers to reducers. The problem we solve is as follows: given a collection of mapper outputs (intermediate key-value pairs) and a partitioning of this collection among the reducers, which node should each reducer run on to minimize data transfer? We reduce two natural formulations of this problem to optimization problems for which polynomial solutions exist. We show that our techniques can cut communication costs by 50 percent or more compared to Hadoop's default reducer placement, which leads to lower network utilization and faster MapReduce job runtimes.
Multicast routing protocol for Ad Hoc Networks with a Quality of Service << Qos-AODV >>

The evolution of telecommunications is characterized by an increase of availability of bandwidth and the user mobility. It takes to a revolution in offers of the service quality. The notion of quality of service (QoS) becomes then an important concept if one wants to transport information with a maximum of reliability. The most important metrics of QoS are the rate, the delay (as well as the jig) and the rate of losses. In this paper, a routing protocol that integrates this concept of QoS is conceived and is given back efficient in NS-2 to study its performances. The initial objective of our work was to conceive a reliable protocol that distributes packets sent by one or several senders to several recipients with an elevated percentage of success. Qos-AODV is conceived in order to extricate profit of that is made in the AODVprotocol. It uses the different tables of neighbors, of topology and for routing, in order to minimize the delay and the traffic of control. The results show that QoS is essential for multicast routing in ad hoc networks.
Energy efficient relay networks with wireless power transfer from a multi‐antenna base station

In this paper, we investigate the energy efficiency (EE) of a decode‐and‐forward relay network with wireless energy harvesting. The data transmission between a multi‐antenna base station (BS) and its user equipment is assisted by an intermediate relay node, which operates with the wireless energy harvesting. The BS firstly transmits energy and information to the relay node, which can harvest the energy and retract the information simultaneously using the power‐splitting or time‐switching method. Then, the relay node forwards its decoded information to the user equipment using all the harvested energy. Through maximising the instantaneous EE for the power‐splitting‐based system, the optimal power‐splitting ratio and the optimal transmit power of the BS are derived in closed form for each time block. To maximise the instantaneous EE for the time‐switching‐based system, an optimisation algorithm is proposed to judiciously determine the harvesting time and the transmit power of the BS for each time block. Furthermore, we optimise the number of antennas N of the BS by taking into account the circuit power consumption, as it cannot be ignored when N is large. Finally, simulation results are presented to validate our derived closed‐form solutions and verify the efficiency of our proposed algorithm. Copyright © 2015 John Wiley & Sons, Ltd.
PENGARUH PREMANAGED EARNINGS DAN DIVIDEN YANG DIHARAPKAN TERHADAP PRAKTIK MANAJEMEN LABA

This study aims to determine whether the companies paying dividend in the previous year (payers) are more likely to perform earnings management than companies that do not (non-payers) in order to meet the expected dividend. The study also examines the impact of premanaged earnings and expected dividend on earnings management practices. Sample used in this research are manufacturing companies listed in Indonesia Stock Exchange in 2010-2012. The findings suggest that there is a significant negative relationship between premanaged earnings and discretionary accruals, and a significant positive relationship between the expected dividends and discretionary accruals. This study concludes that dividend is important determinant of earnings thresholds. However, dividend is not a unique motivation to perform earnings management. Keywords: earnings management, expected dividend, premanaged earnings, dividend thresholds --- Penelitian ini bertujuan untuk mengetahui apakah perusahaan yang membayarkan dividen di tahun sebelumnya (payers) lebih cenderung melakukan manajemen laba daripada perusahaan yang tidak membayarkan dividen di tahun sebelumnya (non-payers) agar dapat memenuhi dividen yang diharapkan. Penelitian menguji bagaimana pengaruh premanaged earnings dan dividen yang diharapkan dengan praktik manajemen laba. Penelitian ini menggunakan sampel badan usaha manufaktur yang terdaftar di BEI periode 2010-2012 dengan menggunakan teknik purposive/judgement sampling. Temuan menunjukkan premanaged earnings berpengaruh negatif signifikan terhadap akrual diskresioner yang merupakan proksi dari manajemen laba. Penelitian ini menyimpulkan meskipun dividen yang diharapkan adalah salah satu penentu earnings threshold, namun dividen bukan menjadi unique motivation untuk melakukan manajemen laba. Kata kunci: manajemen laba, expected dividend, premanaged earnings, dividend thresholds