Miracle-dz/UniFAR-FTUs huggingface dataset:
Midterm Outcome of Primary Arterial Switch Operation Beyond Six Weeks of Life in Children With Transposition of Great Arteries and Intact Ventricular Septum

Background: We have previously reported our experience in primary arterial switch operation (ASO) in children more than six weeks with transposition of great arteries and intact ventricular septum (TGA/IVS). The upper age limit for performing an ASO in these children is not yet settled and reports regarding outcome of ASO in these children are few. In this prospective observational study, we report the midterm results of children with TGA-IVS older than six weeks undergoing primary ASO. Methods: A total of 109 children aged more than 6 weeks with median age of 60 days (range 42-3,000 days), with regressed left ventricle underwent primary ASO. Extracorporeal membrane oxygenation was used in 20% (22 of 109) of them; 90.8% (99 of 109) of children who survived were prospectively followed, with a mean follow-up of 28 months (range 18-84 months). Results: Two late deaths occurred, and survival in the remainder was estimated to be 98% at seven years. The incidence of aortic regurgitation (AR) was found to have a decreasing trend with freedom from AR approaching 100% by 34 months. The left ventricular shape and function returned to normal within one to three months following surgery. None of these children had any rhythm disturbances or evidence of myocardial ischemia. Conclusions: Primary ASO can be safely performed in children with regressed ventricle, irrespective of age with encouraging results. The midterm results of these children are comparable in terms of survival and freedom from complications associated with preserved ventricle.
Effect of Trace Elements on Anaerobic Digestion of Coking Wastewater

The pretreatment of coking wastewater using ASBR was conducted at 35¿ in this paper. The addition of trace elements to the anaerobic reactor has positive effect on the anaerobic treatment of coking wastewater, but too much or too little of it will have negative effect. At the same time the addition of trace elements will be a large cost in field scale anaerobic wastewater treatment. So it is necessary to assay the optimal addition of trace elements to either enhance the anaerobic treatment efficiency or save the cost of addition trace elements. As the coking wastewater is generated in the coal gas purification and by-product recovery processes, there will be some trace elements remain in wastewater, which can save the cost of addition trace elements to coking wastewater than other wastewater anaerobic treatment. After three months’ stable operation at the optimal conditions and with the general addition of trace elements in ASBR, the optimal addition of trace elements was conducted in this study. In the condition of the addition of 60% of general trace elements into ASBR reactor, the COD removal rate could reach as high as 67.8% and had a high biomass remain in the reactor. But too low concentration of trace elements resulted in poor treatment efficiency. When the amounts of trace elements added into the ASBR decreased from 100% to 60%of general addition, the configuration of granular turned looser and the dominant bacteria in the granular turned from Methanosarcina to Methanosaeta.
Pancreas transplantation in the United States: a review

Purpose of reviewThe goal of pancreas transplantation is to restore normoglycemia in patients with labile diabetes. The results of this procedure improved over the years, but, although pancreas transplantation is not considered experimental anymore, there is often reluctance to recommend this procedure because of the complexity, especially for solitary pancreas transplants. This article reviews the current status of pancreas transplantation. Recent findingsMany improvements have been made in the surgical techniques and immunosuppressive regimens. The overall rate of technical problems decreased, yet immunologic graft loss is still a problem in solitary pancreas transplants. Careful donor selection significantly decreased the risk of graft failure and therefore improved patient survival. SummaryWith modern immunosuppressive protocols and careful donor selection, patient survival rates and pancreas transplant graft function can be further improved in all three pancreas transplant categories.
A partial homomorphic encryption scheme for secure design automation on public clouds

The massive compute power offered by public clouds such as Amazon Web Services EC2 provides for a new paradigm in cost-effective and highly scalable parallel deployment of Electronic Design Automation (EDA) tools. Even though the advantages are myriad, customers perceive an inherent security risk in exposing their IP to the cloud. In this work, we start by outlining the shortcomings of established encryption techniques for use in public machines. Using the example of electromagnetic simulation, we show how the IP (layout and technology) may be reverse-engineered from the Green's function matrix by utilizing the Multi Dimensional Scaling approach. We then propose encryption schemes to defeat such sophisticated hacking attempts using principles of homomorphic encryption, while enabling scalability and computational benefits of public clouds.
Changes of Heart: The Switch-Value Method for Assessing Value Uncertainty

Background. Medical choices often evoke great value uncertainty, as patients face difficult, unfamiliar tradeoffs. Those seeking to aid such choices must be able to assess patients’ ability to reduce that uncertainty, to reach stable, informed choices. Objective. The authors demonstrate a new method for evaluating how well people have articulated their preferences for difficult health decisions. The method uses 2 evaluative criteria. One is internal consistency, across formally equivalent ways of posing a choice. The 2nd is compliance with principles of prospect theory, indicating sufficient task mastery to respond in predictable ways. Method. Subjects considered a hypothetical choice between noncurative surgery and palliative care, posed by a brain tumor. The choice options were characterized on 6 outcomes (e.g., pain, life expectancy, treatment risk), using a drug facts box display. After making an initial choice, subjects indicated their willingness to switch, given plausible changes in the outcomes. These changes involved either gains (improvements) in the unchosen option or losses (worsening) in the chosen one. A 2 × 2 mixed design manipulated focal change (gains v. losses) within subjects and change order between subjects. Results. In this demonstration, subjects’ preferences were generally consistent 1) with one another: with similar percentages willing to switch for gains and losses, and 2) with prospect theory, requiring larger gains than losses, to make those switches. Conclusion. Informed consent requires understanding decisions well enough to articulate coherent references. The authors’ method allows assessing individuals’ success in doing so.
Virtual Optical Network Embedding (VONE) Over Elastic Optical Networks

Based on the concept of infrastructure as a service, optical network virtualization can facilitate the sharing of physical infrastructure among different users and applications. In this paper, we design algorithms for both transparent and opaque virtual optical network embedding (VONE) over flexible-grid elastic optical networks. For transparent VONE, we first formulate an integer linear programming (ILP) model that leverages the all-or-nothing multi-commodity flow in graphs. Then, to consider the continuity and consecutiveness of substrate fiber links' (SFLs') optical spectra, we propose a layered-auxiliary-graph (LAG) approach that decomposes the physical infrastructure into several layered graphs according to the bandwidth requirement of a virtual optical network request. With LAG, we design two heuristic algorithms: one applies LAG to achieve integrated routing and spectrum assignment in link mapping (i.e., local resource capacity (LRC)-layered shortest-path routing LaSP), while the other realizes coordinated node and link mapping using LAG (i.e., layered local resource capacity(LaLRC)-LaSP). The simulation results from three different substrate topologies demonstrate that LaLRC-LaSP achieves better blocking performance than LRC-LaSP and an existing benchmark algorithm. For the opaque VONE, an ILP model is also formulated. We then design a LRC metric that considers the spectrum consecutiveness of SFLs. With this metric, a novel heuristic for opaque VONE, consecutiveness-aware LRC-K shortest-path-first fit (CaLRC-KSP-FF), is proposed. Simulation results show that compared with the existing algorithms, CaLRC-KSP-FF can reduce the request blocking probability significantly.
Biochemistry and molecular biology of Arabidopsis–aphid interactions

To ensure their survival in natural habitats, plants must recognize and respond to a wide variety of insect herbivores. Aphids and other Hemiptera pose a particular challenge, because they cause relatively little direct tissue damage when inserting their slender stylets intercellularly to feed from the phloem sieve elements. Plant responses to this unusual feeding strategy almost certainly include recognition of aphid salivary components and the induction of phloem‐specific defenses. Due to the excellent genetic and genomic resources that are available for Arabidopsis thaliana (Arabidopsis), this plant was chosen as a model system to study the metabolic and transcriptional responses to infestation by two aphids, Myzus persicae (green peach aphid, a broad generalist) and Brevicoryne brassicae (cabbage aphid, a crucifer‐feeding specialist). Future research on Arabidopsis–aphid interactions will lead to the identification of aphid‐specific elicitors, components of the defense‐signaling pathway, and additional metabolic responses that are induced by aphid infestation. BioEssays 29:871–883, 2007. © 2007 Wiley Periodicals, Inc.
Comparison of plasma Epstein–Barr virus (EBV) DNA levels and serum EBV immunoglobulin A/virus capsid antigen antibody titers in patients with nasopharyngeal carcinoma

Serologic measurement of antibodies to Epstein–Barr virus (EBV) immunoglobulin A/viral capsid antigen (IgA/VCA) and early antigen (IgA/EA) has been used widely to screen for nasopharyngeal carcinoma (NPC) in China. Recently, it was found that plasma EBV DNA concentration is an indicator for the staging and prognosis of patients with NPC. To determine whether there is a correlation between plasma EBV DNA levels and serum levels of IgA/VCA, the authors measured both in patients with NPC and in a control group.
Sub-similarity matching based on data mining with dihedral angles

Protein sub-similarity matching remains largely unknown even though it is becoming one of the most important open problems in bioinformatics for drug and vaccine design. Variations in human immune responses to vaccines are, and thus responses, fail. We propose a new matching and protein alignment method based on clustering and Longest Common Subsequence (LCS) techniques. After clustering, we found LCS between a candidate protein and meningitis outer membrane antigen for each candidate. Each similarity was scored, and closest similarities were determined with statistical methods. We located three closely matching proteins among a total of 50 human immune system proteins. Moreover, we selected a HIV-1 related protein from one of scenarios, because it revealed a relationship between HIV and meningitis patients. We also found that Ω main chain torsion angle for atoms CA, C and N is the best angle for determining sub-similarities between meningitis antigen and immune proteins.
Parkinson's disease mortality and pesticide exposure in California 1984-1994.

BACKGROUND In the last two decades reports from different countries emerged associating pesticide and herbicide use with Parkinson's disease (PD). California growers use approximately 250 million pounds of pesticides annually, about a quarter of all pesticides used in the US. METHODS We employed a proportional odds mortality design to compare all cases of PD recorded as underlying (1984-1994) or associated causes (1984-1993) of death occurring in California with all deaths from ischaemic heart disease (ICD-9 410-414) during the same period. Based on pesticide use report data we classified California counties into several pesticide use categories. Agricultural census data allowed us to create measures of percentage of land per county treated with pesticides. Employing logistic regression models we estimated the effect of pesticide use controlling for age, gender, race, birthplace, year of deaths, and education. RESULTS Mortality from PD as the underlying cause of death was higher in agricultural pesticide-use counties than in non-use counties. A dose response was observed for insecticide use per county land treated when using 1982 agricultural census data, but not for amounts of restricted pesticides used or length of residency in a country prior to death. CONCLUSIONS Our data show an increased PD mortality in California counties using agricultural pesticides. Unless all of our measures of county pesticide use are surrogates for other risk factors more prevalent in pesticide use counties, it seems important to target this prevalent exposure in rural California in future studies that use improved case finding mechanisms and collect pesticide exposure data for individuals.
A Compact Memristor-Based Dynamic Synapse for Spiking Neural Networks

Recent advances in memristor technology lead to the feasibility of large-scale neuromorphic systems by leveraging the similarity between memristor devices and synapses. For instance, memristor cross-point arrays can realize dense synapse network among hundreds of neuron circuits, which is not affordable for traditional implementations. However, little progress was made in synapse designs that support both static and dynamic synaptic properties. In addition, many neuron circuits require signals in specific pulse shape, limiting the scale of system implementation. Last but not least, a bottom-up study starting from realistic memristor devices is still missing in the current research of memristor-based neuromorphic systems. Here, we propose a memristor-based dynamic (MD) synapse design with experiment-calibrated memristor models. The structure obtains both static and dynamic synaptic properties by using one memristor for weight storage and the other as a selector. We overcame the device nonlinearities and demonstrated spike-timing-based recall, weight tunability, and spike-timing-based learning functions on MD synapse. Furthermore, a temporal pattern learning application was investigated to evaluate the use of MD synapses in spiking neural networks, under both spike-timing-dependent plasticity and remote supervised method learning rules.
Proteolytic processing of Ty3 proteins is required for transposition

Ty3 is a retroviruslike element found in Saccharomyces cerevisiae. It encodes GAG3 and GAG3-POL3 polyproteins which are processed into mature proteins found in the Ty3 viruslike particle. In this study, the region encoding a protease that is homologous to retroviral aspartyl proteases was identified and shown to be required for production of mature Ty3 proteins and transposition. The Ty3 protease has the Asp-Ser-Gly consensus sequence found in copia, Ty1, and Rous sarcoma virus proteases, rather than the Asp-Thr-Gly found in most retroviral proteases. The Asp-Ser-Gly consensus is flanked by residues similar to those which flank the active sites of cellular aspartyl proteases. Mutations were made in the Ty3 active-site sequence to examine the role of the protease in Ty3 particle maturation and to test the functional significance of the Ser active-site variant in the consensus sequence. Mutation of the active-site Asp blocked processing of Gag3 and Gag3-Pol3 and allowed identification of a GAG3-POL3 polyprotein. This protein was turned over rapidly in cells expressing the mutant Ty3. Changing the active-site Ser to Thr caused only a modest reduction in the levels of certain Ty3 proteins. Five putative cleavage sites of this protease in Ty3 GAG3 and GAG3-POL3 polyproteins were defined by amino-terminal sequence analysis. The existence of an additional protein(s) of unknown function, encoded downstream of the protease-coding region, was deduced from the positions of these amino termini and the sizes of known Ty3 proteins. Although Ty3 protease cleavage sites do not correspond exactly to known retroviral protease cleavage sites, there are similarities. Residues P3 through P2' in the regions encompassing each of the five sites are uncharged, and no P1 position is occupied by an amino acid with a branched beta carbon.
EXPLICIT FORMULAE FOR PARAMETERS OF STOCHASTIC MODELS OF A DISCOUNTED EQUITY INDEX USING MAXIMUM LIKELIHOOD ESTIMATION WITH APPLICATIONS

A discounted equity index is computed as the ratio of an equity index to the accumulated savings account denominated in the same currency. In this way, discounting provides a natural way of separating the modeling of the short rate from the market price of risk component of the equity index. In this vein, we investigate the applicability of maximum likelihood estimation to stochastic models of a discounted equity index, providing explicit formulae for parameter estimates. We restrict our consideration to two important index models, namely the Black–Scholes model and the minimal market model of Platen, each having an explicit formula for the transition density function. Explicit formulae for estimates of the model parameters and their standard errors are derived and are used in fitting the two models to US data. Further, we demonstrate the effect of the model choice on the no-arbitrage assumption employed in risk neutral pricing.
Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies.

Pulse wave velocity is widely used as an index of arterial distensibility. The aim of this study was to evaluate the accuracy of a new automatic device to measure it and then to analyze the major determinants of pulse wave velocity by application of this device in a large population. We evaluated the accuracy of on-line and computerized measurement of pulse wave velocity using an algorithm based on the time-shifted and repeated linear correlation calculation between the initial rise in pressure waveforms compared with the reference method (manual calculation) in 56 subjects. The results, analyzed according to the recommendations of Bland and Altman, showed a mean difference of -0.20 +/- 0.45 m/s for the mean carotid-femoral pulse wave velocity values (reference method, 11.05 +/- 2.58 m/s; automatic device, 10.85 +/- 2.44 m/s). The interreproducibility and intrareproducibility of measurements by each method were analyzed with the use of the repeatability coefficient according to the British Standards Institution. The interobserver repeatability coefficient was 0.947 for the manual method and 0.890 for the automatic, and intraobserver repeatability coefficients were 0.938 and 0.935, respectively. We evaluated the major determinants of the carotid-femoral pulse wave velocity measured by the automatic method in a separate study performed in 418 subjects of both sexes without any cardiovascular treatment or complication (18 to 77 years of age; 98 to 222 mm Hg systolic and 62 to 130 mm Hg diastolic pressure). (ABSTRACT TRUNCATED AT 250 WORDS)
An alternative approach to design reconfigurable mixed signal VLSI DA based FIR filter

This paper presents an alternative approach to design reconfigurable mixed signal distributed arithmetic (DA) based finite impulse response (FIR) filter. The proposed architecture is based on the use of normal CMOS transistor for various computational blocks involved in the filter design. To maintain the reconfigurability, an electrically erasable programmable read only memory (EEPROM) based potentiometer (POT) is also employed that stores the analog filter weights. Moreover, the analog weights are separately added in last cycle corresponding to most significant bit and eliminates the extra control circuitry for bit-inversion. We have simulated the proposed architecture in UMC 180 nm CMOS using Cadence Spectre with input sampling frequency of 1.25 MHz. It is found that the proposed architecture dissipates the static power of 4.85 mW.
Doctoral education reform in Finland – institutionalized and individualized doctoral studies within European framework

ABSTRACT In Europe, doctoral education systems have been systematically reformed. These reforms are aimed at improving the quality of research and the competitiveness of European countries. In Finland, the reform project of doctoral education started vigorously in the mid-1990s which has contributed significantly to the emergence of more structured doctoral training. The starting point for this article was a recent national follow-up evaluation of doctoral education in Finland. The results are based on qualitative analysis of a survey and interview data collected in the evaluation. The results showed that Finnish universities are launching the university-wide graduate school model. Each university is building a single or several graduate schools consisting of doctoral programmes compatible with the university’s research strategies and profiles. Today, there is an apparent need to increase doctoral students’ participation in the reform processes. It can be argued that there is discrepancy between the official statements of the doctoral students’ key position in promoting research excellence within the European context and the actual doctoral training practices at institutional level. Therefore, we need to explore doctoral students’ study conditions from their own perspective, in order to get a better picture of how the new university-wide graduate schools and doctoral programmes promote doctoral graduation in academic, pedagogical and cultural terms.
The Low-Carbon Transition toward Sustainability of Regional Coal-Dominated Energy Consumption Structure: A Case of Hebei Province in China

CO2 emission resulted from fossil energy use is threatening human sustainability globally. This study focuses on the low-carbon transition of Hebei’s coal-dominated energy system by estimating its total end-use energy consumption, primary energy supply and resultant CO2 emission up to 2030, by employing an energy demand analysis model based on setting of the economic growth rate, industrial structure, industry/sector energy consumption intensity, energy supply structure, and CO2 emission factor. It is found that the total primary energy consumption in Hebei will be 471 and 431 million tons of coal equivalent (tce) in 2030 in our two defined scenarios (conventional development scenario and coordinated development scenario), which are 1.40 and 1.28 times of the level in 2015, respectively. The resultant full-chain CO2 emission will be 1027 and 916 million tons in 2030 in the two scenarios, which are 1.24 and 1.10 times of the level in 2015, respectively. The full-chain CO2 emission will peak in about 2025. It is found that the coal-dominated situation of energy structure and CO2 emission increasing trend in Hebei can be changed in the future in the coordinated development scenario, in which Beijing-Tianjin-Hebei area coordinated development strategy will be strengthened. The energy structure of Hebei can be optimised since the proportion of coal in total primary energy consumption can fall from around 80% in 2015 to below 30% in 2030 and the proportions of transferred electricity, natural gas, nuclear energy and renewable energy can increase rapidly. Some specific additional policy instruments are also suggested to support the low-carbon transition of energy system in Hebei under the framework of the coordinated development of Beijing-Tianjin-Hebei area, and with the support from the central government of China.