Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive Impairment after Chemotherapy Related to Atypical Network Architecture for Executive Control

Objectives: A common complaint of cancer patients is the experience of cognitive difficulty during and after chemotherapy. We hypothesized that cognitive impairment may result from dysfunction in large-scale brain networks, particularly those involved in attentional control. Methods: Using a case-control design, this study includes women with a history of invasive ductal or lobular triple-negative breast cancer who completed standard adjuvant chemotherapy within 2 years of study entry. Women who reported cognitive impairment by the Global Rating of Cognition question were considered to be cases (n = 15). Women who reported no cognitive impairment were considered to be controls (n = 13). All enrolled participants were eligible for MRI investigation and underwent resting-state functional connectivity MRI. Results: Women who self-reported cognitive impairment were found to have disrupted resting-state functional connectivity, as measured by MRI, when compared to women who did not self-report cognitive impairment. These findings suggest that some women may be more sensitive to the standard treatments for breast cancer and that this increased sensitivity may result in functional connectivity alterations in the brain networks supporting attention and executive function. Conclusions: Neuroimaging analyses confirmed self-reported cognitive deficits in women with breast cancer treated with chemotherapy.
GIT1 is a novel MEK1–ERK1/2 scaffold that localizes to focal adhesions

Cell polarity is critical for cell migration and requires localized signal transduction in subcellular domains. Recent evidence demonstrates that activation of ERK1/2 (extracellular‐signal‐regulated kinase 1/2) in focal adhesions is essential for cell migration. GIT1 (G‐protein‐coupled receptor kinase‐interacting protein 1) has been shown to bind paxillin and regulate focal‐adhesion disassembly. We have previously reported that GIT1 binds to MEK1 [MAPK (mitogen‐activated protein kinase)/ERK kinase 1] and acts as a scaffold to enhance ERK1/2 activation in response to EGF (epidermal growth factor). In the present study we show that GIT1 associates with ERK1/2 in focal adhesions and this association increases after EGF stimulation. The CC (coiled‐coil) domain of ERK1/2 is required for association with GIT1, translocation to focal adhesions, and cell spreading and migration. Immunofluorescent staining showed that, after EGF stimulation, GIT1 co‐localized with pERK1/2 (phosphorylated ERK1/2) in focal adhesions. The binding of GIT1 and ERK1/2 was functionally important, since transfecting an ERK2 mutant lacking the CC domain [ERK2(del CC)] significantly decreased pERK1/2 translocation to focal adhesions, cell spreading and migration induced by EGF. In summary, the CC domain of ERK1/2 is necessary for binding to GIT1, for ERK1/2 activation in focal adhesions, and for cell spreading and migration.
Effect of an oral Shiga toxin-binding agent on diarrhea-associated hemolytic uremic syndrome in children: a randomized controlled trial.

CONTEXT Diarrhea-associated hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children. Most cases are caused by an intestinal infection with Shiga toxin-producing strains of Escherichia coli. OBJECTIVE To determine if administration of an oral agent that binds Shiga toxin could diminish the severity of diarrhea-associated HUS in pediatric patients. DESIGN, SETTING, AND PATIENTS Multicenter, randomized, double-blind, placebo-controlled clinical trial of 145 children (96 experimental and 49 placebo) aged 6 months to 18 years with diarrhea-associated HUS conducted between July 27, 1997, and April 14, 2001, at 26 tertiary care pediatric nephrology centers in the United States and Canada. Trial included 2 phases, the hospital course for treatment of the acute illness and a 60-day outpatient follow-up period after discharge from the hospital. INTERVENTION Patients were assigned to receive the binding agent, 500 mg/kg daily, or cornmeal placebo orally for 7 days in a 2:1 randomization scheme. MAIN OUTCOME MEASURES Combined frequency of death or serious extrarenal events and need for dialysis in the experimental vs placebo group. RESULTS A total of 62 patients (43%) were male and 123 (85%) were white. The median age of the patients was 4.2 years. Most patients (59%) were transferred from other hospitals to participating sites. The severity of disease at the time of randomization was comparable in the 2 groups. The prevalence of death or serious extrarenal events was 18% and 20% in the experimental and placebo groups, respectively (P =.82). Dialysis was required in 42% of experimental and 39% of placebo groups (P =.86). CONCLUSIONS Oral therapy with a Shiga toxin-binding agent failed to diminish the severity of disease in pediatric patients with diarrhea-associated HUS.
FREQUENCY OF INPUT AND L2 COLLOCATIONAL PROCESSING

This study investigated the influence of frequency effects on the processing of congruent (i.e., having an equivalent first language [L1] construction) collocations and incongruent (i.e., not having an equivalent L1 construction) collocations in a second language (L2). An acceptability judgment task was administered to native and advanced nonnative English speakers (L1 Swedish) to assess response times to and error rates for these collocations along with a matched set of unrelated items. The results suggested that advanced learners are highly sensitive to frequency effects for L2 collocations, which seems to support the idea that usage-based models of language acquisition can be fruitfully applied to understanding the processes that underlie L2 collocational acquisition. At the same time, however, the apparent continued influence of the L1 indicates that researchers may also want to draw on other models of language acquisition to gain a fuller understanding of the processes underlying the acquisition of collocations in a L2.
Performance in Electronic Marketplaces: Theory in Practice

Theories of interorganizational coordination propose that that the fit between information processing capabilities (structure, process and technology) and information processing needs (environmental, partnership and task uncertainty) is a strong determinant of IOS performance. Recently, electronic marketplaces have replaced many traditional interorganizational systems (IOS). While traditional IOS models predominately operationalize one‐to‐one relationships, electronic marketplaces are mainly characterized as one‐to‐many and many‐to‐many. Consequently, it is reasonable to question whether the performance of electronic marketplaces can be adequately explained by the fit between information processing needs and information processing capabilities. This paper develops a conceptual model in an effort to explain more adequately the performance of electronic marketplaces. The argument advanced is that performance is dependent on not only the fit between (a) the information processing needs and information proces.
SPL7013 Gel (VivaGel®) Retains Potent HIV-1 and HSV-2 Inhibitory Activity following Vaginal Administration in Humans

SPL7013 Gel (VivaGel®) is a microbicide in development for prevention of HIV and HSV. This clinical study assessed retention and duration of antiviral activity following vaginal administration of 3% SPL7013 Gel in healthy women. Participants received 5 single doses of product with ≥5 days between doses. A cervicovaginal fluid (CVF) sample was collected using a SoftCup™ pre-dose, and immediately, or 1, 3, 12 or 24 h post-dose. HIV-1 and HSV-2 antiviral activities of CVF samples were determined in cell culture assays. Antiviral activity in the presence of seminal plasma was also tested. Mass and concentration of SPL7013 in CVF samples was determined. Safety was assessed by reporting of adverse events. Statistical analysis was performed using the Wilcoxon signed-rank test with Bonferroni adjustment; p≤0.003 was significant. Eleven participants completed the study. Inhibition of HIV-1 and HSV-2 by pre-dose CVF samples was negligible. CVF samples obtained immediately after dosing almost completely inhibited (median, interquartile range) HIV-1 [96% (95,97)] and HSV-2 [86% (85,94)], and activity was maintained in all women at 3 h (HIV-1 [96% (95,98), p = 0.9]; HSV-2 [94% (91,97), p = 0.005]). At 24 h, >90% of initial HIV-1 and HSV-2 inhibition was maintained in 6/11 women. SPL7013 was recovered in CVF samples obtained at baseline (46% of 105 mg dose). At 3 and 24 h, 22 mg and 4 mg SPL7013, respectively, were recovered. More than 70% inhibition of HIV-1 and HSV-2 was observed if there was >0.5 mg SPL7013 in CVF samples. High levels of antiviral activity were retained in the presence of seminal plasma. VivaGel was well tolerated with no signs or symptoms of vaginal, vulvar or cervical irritation reported. Potent antiviral activity was observed against HIV-1 and HSV-2 immediately following vaginal administration of VivaGel, with activity maintained for at least 3 h post-dose. The data provide evidence of antiviral activity in a clinical setting, and suggest VivaGel could be administered up to 3 h before coitus. Trial Registration The study is registered at ClinicalTrials.gov under identifier: NCT00740584
Concentric mosaic(s), planar motion and 1D cameras

General SFM methods give poor results for images captured by constrained motions such as planar motion of concentric mosaics (CM). In this paper we propose new SFM algorithms for both images captured by CM and composite mosaic images from CM. We first introduce ID affine camera model for completing 1D camera models. Then we show that a 2D image captured by CM can be decoupled into two 1D images: one 1D projective and one ID affine; a composite mosaic image can by rebinned into a calibrated ID panorama projective camera. Finally we describe subspace reconstruction methods and demonstrate both in theory and experiments the advantage of the decomposition method over the general SFM methods by incorporating the constrained motion into the earliest stage of motion analysis.
Express Cubes: Improving the Performance of k-Ary n-Cube Interconnection Networks

The author discusses express cubes, k-ary n-cube interconnection networks augmented by express channels that provide a short path for nonlocal messages. An express cube combines the logarithmic diameter of a multistage network with the wire-efficiency and ability to exploit locality of a low-dimensional mesh network. The insertion of express channels reduces the network diameter and thus the distance component of network latency. Wire length is increased, allowing networks to operate with latencies that approach the physical speed-of-light limitation rather than being limited by node delays. Express channels increase wire bisection in a manner that allows the bisection to be controlled independently of the choice of radix, dimension, and channel width. By increasing wire bisection to saturate the available wiring media, throughput can be substantially increased. With an express cube both latency and throughput are wire-limited and within a small factor of the physical limit on performance. >
Motivation, Leadership, Empowerment and Confidence: Their Relation with Nurses’ Burnout

Introduction: Burnout is usually defined as a state of physical, emotional and mental exhaustion that results from long-term involvement in work situations that are emotionally demanding. A great deal of researches has been devoted to the understanding of factors contributing to burnout and the negative effects that burnout has in the cost and the quality of the provided healthcare. Discussion: Many researchers believe that in difficult and stressful working conditions the work environment should be changed in order to reduce burnout levels successfully. Indeed, recent studies have highlighted the role of human resources management in burnout. It has been widely recognized that human resource management policies should be at the core of any sustainable solution that aims to increase health care systems performance and efficient. Conclusion: Motivation, leadership, empowerment and confidence are very important factors that should be considered in this direction because they are strongly related with burnout levels.
INDIGO: An In Situ Distributed Gossip Framework for Sensor Networks

With the onset of Cyber-Physical Systems (CPS), distributed algorithms on Wireless Sensor Networks (WSNs) have been receiving renewed attention. The distributed consensus problem is a well studied problem having a myriad of applications which can be accomplished using asynchronous distributed gossip algorithms on Wireless Sensor Networks (WSNs). However, a practical realization of gossip algorithms for WSNs is found lacking in the current state of the art. In this paper, we propose the design, development, and analysis of a novel in situ distributed gossip framework called INDIGO. A key aspect of INDIGO is its ability to perform on a generic system platform as well as on a hardware oriented testbed platform in a seamless manner allowing easy portability of existing algorithms. We evaluate the performance of INDIGO with respect to the distributed consensus problem as well as the distributed optimization problem. We also present a data driven analysis of the effect certain operating parameters like sleep time and wait time have on the performance of the framework and empirically attempt to determine a sweet spot. The results obtained from various experiments on INDIGO validate its efficacy, reliability, and robustness and demonstrate its utility as a framework for the evaluation and implementation of asynchronous distributed algorithms.
Erfassung von Arbeitsengagement bei Patienten mit hämatologischen Malignomen: Die psychometrischen Eigenschaften der deutschen Version der Utrecht Work Engagement Scale 9 (UWES-9)

Zusammenfassung Ziel der Studie: Zielsetzung ist die psychometrische Überprüfung der deutschen Version der Utrecht Work Engagement Scale-9 (UWES-9), einem 9-Item langen Selbstbeurteilungsinstrument zur Erfassung von Arbeitsengagement. Methodik: Auf Grundlage einer Stichprobe von 179 Patienten mit hämatologischen Malignomen in akutstationärer oder rehabilitativer Behandlung wurde die dimensionale Struktur der UWES-9 konfirmatorisch und exploratorisch analysiert und bezüglich Reliabilität, Itemkennwerten sowie Konstruktvalidität überprüft. Ergebnisse: Die konfirmatorische Faktorenanalyse der UWES-9 ergibt akzeptable Modell-Fit-Indizes sowohl für die 1-dimensionale als auch die 3-dimensionale Faktorlösung. Die explorative Hauptkomponentenanalyse konnte die 1-dimensionale Faktorenstruktur replizieren, die 67% der Varianz aufklärt und sich durch eine sehr hohe interne Konsistenz (α=0,94) und hohe Faktorladungen (0,73–0,88) auszeichnet. Die Konstruktvalidität wird unterstützt durch signifikante und positive Korrelationen u. a. mit Bedeutung und Verbundenheit mit der Arbeit, Gemeinschaftsgefühl und allgemeiner Arbeitszufriedenheit. Fazit: Die deutschsprachige UWES-9 weist eine gute psychometrische Qualität in der 1-dimensionalen Erfassung von beruflichem Engagement bei Patienten mit hämatologischen Malignomen in einem akutstationären sowie stationär-rehabilitativen Setting auf.
The Vulnerability Dataset of a Large Software Ecosystem

Security bugs are critical programming errors that can lead to serious vulnerabilities in software. Examining their behaviour and characteristics within a software ecosystem can provide the research community with data regarding their evolution, persistence and others. We present a dataset that we produced by applying static analysis to the Maven Central Repository (approximately 265GB of data) in order to detect potential security bugs. For our analysis we used FindBugs, a tool that examines Java bytecode to detect numerous types of bugs. The dataset contains the metrics' results that FindBugs reports for every project version (a JAR) included in the ecosystem. For every version in our data repository, we also store specific metadata, such as the JAR's size, its dependencies and others. Our dataset can be used to produce interesting research results involving security bugs, as we show in specific examples.
Can consumers' global/local consumption orientation be primed?

Cultural frame switching (CFS) theory has been utilized in several studies which have found an individual’s self-concept is malleable through the use of priming effects (e.g., national icons, national flags, and words). In this study we test consumers’ responses to priming effects (world map vs. national flag) on the antecedents towards global consumption orientation (GCO). The results support the malleability of the global/local self. Respondents who were primed with the world map showed a higher level internal cosmopolitanism, which in turn had a greater influence on their GCO, whereas respondents who were primed with their national flag showed a greater influence of external cosmopolitanism on their GCO.
RnBeads – Comprehensive Analysis of DNA Methylation Data

RnBeads is an R package for the comprehensive analysis of genome-wide DNA methylation data with single basepair resolution. Supported assays include the Infinium 450k microarray, whole genome bisulfite sequencing (WGBS), reduced representation bisulfite sequencing (RRBS), other forms of enrichment bisulfite sequencing, and any other large-scale method that can provide DNA methylation data at single basepair resolution (e.g. MeDIP-seq after suitable preprocessing). It builds upon a significant and ongoing community effort to devise effective algorithms for dealing with large-scale DNA methylation data and implements these methods in a user-friendly, high-throughput workflow, presenting the analysis results in a highly interpretable fashion.
Lack of Amphetamine‐Like Effects After Administration of Mefenorex in Normal Young Subjects

Mefenorex is an indirect sympathomimetic amine which acts as an anorectic drug and is used in combination with low diet to treat excess weight. The central nervous system (CNS) effects of mefenorex were assessed in a randomized, double‐blind, three‐way cross‐over, placebo‐controlled study involving nine healthy young male volunteers. They received either a single oral dose of mefenorex 80 mg (twice the recommended dose) or d‐amphetamine sulfate 18 mg or a placebo at 1‐week intervals. CNS pharmacodynamic measurements consisted of subjective evaluation (visual analogue scales and the Addiction Research Centre inventory (ARCI)), EEG, psychomotor performance and attention (tracking, simple and choice reaction times, tapping, continuous performance task, DSST, body sway) and memory (working memory and recall of a word list). d‐Amphetamine produced a typical psychostimulant EEG profile (significant decrease in slow delta waves and increase in fast beta activities), significantly increased amphetamine, benzedrine and morphine–benzedrine scores of ARCI and significantly decreased body sway compared to placebo and mefenorex. A trend in favour of a stimulant effect occurred for all other parameters (particularly speed of reaction) and no changes of memory were noticed. In contrast, mefenorex did not produce an amphetamine‐like EEG profile, neither significantly changed ARCI scores nor significantly modified psychomotor and memory performance compared to the placebo, although it induced a decrease in body sway. In conclusion, the present results indicate that a single oral dose of mefenorex, at twice the recommended daily dose, does not possess amphetamine‐like subjective and EEG stimulant effects or sensations of well‐being, often encountered with drugs of abuse liability potential, in a healthy young population.
Çocukluktan Erişkinliğe Obsesif Kompulsif Bozuklukta Hatalı Değerlendirme ve İnanç Alanları

Obsesif kompulsif bozuklugun (OKB) etiyolojisine yonelik olarak ortaya konan bilissel modellerden Abartili Sorumluluk Algisi Modeli, Yanlis Yorumlama Modeli ve Bilissel Kontrol Modeli gunumuzde bircok yonden gecerliliklerini surdurmektedirler. Eriskin OKB'nda saptanan cesitli bilislere vurgu yapan bu modellere gore OKB'de etkin olan alti hatali degerlendirme ve inanc alani bulunmaktadir. Bunlar; abartili sorumluluk algisi, dusuncenin onemsenmesi, dusuncelerin kontrolu, abartili tehdit algisi, belirsizlige tahammulsuzluk ve mukemmeliyetciliktir. Erken yaslarda OKB tanisi almis olan kisilerde gorulen hastalik belirtilerinin obsesyonlarin saf kompulsiyonlarla seyredebilmesi, belirtilerin kademeli olarak ortaya cikmasi ve sinsice ilerlemesi noktalarinda ileri yas OKB olgularinda gorulen belirtilerden farklilastigi gorulmektedir. OKB'ye iliskin hatali degerlendirme ve inanc alanlari incelendiginde dusuncenin onemsenmesinin, belirsizlige tahammulsuzlugun ve mukemmeliyetciligin eriskinlikte oldugu gibi, cocukluk ve/veya ergenlik donemlerinde de bulundugu; ancak, cocukluk ve ergenlik donemlerinde gorulen abartilmis sorumluluk algisinin, dusuncelerin kontrolunun ve abartili tehdit algisinin, eriskinlerde oldugu kadar belirgin ve dikkat cekici olmadigi sonucuna ulasilmaktadir. OKB belirtilerinin ve bu bozuklukla ilgili olan hatali degerlendirme ve inanc alanlarinin farkli yas donemlerinde ayristigi noktalar goz onunde bulundurularak erken teshis ve mudahale yoluna gidilmesi OKB tedavisinin gidisati icin onem tasimaktadir. Bu yazinin amaci, OKB etyolojisine yonelik ortaya atilan uc guncel bilissel modeli ve OKB'nin bilissel kuraminin anlasilmasini kolaylastiracak alti hatali degerlendirme ve inanc alanlarinin gelisim donemleri yonunden kisaca incelemektir.
Studies on whole cell fluorescence-based screening for epoxide hydrolases and Baeyer-Villiger monoxygenases

Biocatalysis reactions were performed on microtiter plates (200 µL) aiming at the utilization of fluorogenic substrates (100 µmol L-1) for rapid whole cell screening for epoxide hydrolases (EHs) and Baeyer-Villiger monoxygenases (BVMOs). A final protocol was achieved for EHs, with 3 new enzymatic sources being detected (Agrobacterium tumefaciens, Pichia stipitis, Trichosporom cutaneum). The fluorogenic assay for BVMO did not work as expected. However, an approach to possible variables involved (aeration; pH) provided the first detection of a BVMO activity in T. cutaneum.
Myth: Creativity is too difficult to measure!

time and money. Our challenge is to determine, for individual students or groups, what additional evidence will improue our documentation of their nature and needs, and will enhance our ability to anticipate, implement, and justify our educational decisions. We might propose that the &dquo;critical tests&dquo; for additional data gathering might be: 1. Will these new data give us a better picture of the student’s characteristics and needs? 2. Will these data provide information that will have an actual impact on our instructional plans? Our major goal, therefore, should be to seek all possible information concerning each student. Of course, while there may be some instances in which it will be valuable and necessary to obtain data from large groups of students, we should not overlook the value and importance of the most unique kinds of information we have-those observations, records, products, statements that describe an individual student’s needs comprehensively. Psychologists have long distinguished between &dquo;clinical&dquo; and &dquo;statistical&dquo; data in prediction and decision-making. Clinical sources of information are those that are personal, individual, and qualitative in nature. Statistical data are primarily quantitative. In gifted education, our