Miracle-dz/UniFAR-FTUs huggingface dataset:
Recognizing Intellectual Capital As An Asset

The revised definition of an asset by the FASB and GASB gives way to the recognition of the fair value of another off-balance sheet value. Interest in recognizing intellectual capital as an asset of the organization has grown out of dissatisfaction with traditional financial accounting and reporting directed toward manufacturing, trading of goods, and service activities which ignore the organizational asset values based on knowledge, expertise and technology. The growing interest in intellectual capital (IC) and knowledge management reflects an awareness of the need for identification, utilization, and measurement of an organization’s most valuable asset. This paper identifies the importance of the IC value, discusses the research emphasis placed on it by others, and develops a fair value measurement model. The model provides a basis not only for identifying crucial aspects of effective knowledge management, but also for emphasizing the interdependence, and the synergy that may be created through recognition. Measurement techniques are presented together with a process for stakeholder communication that establishes the groundwork for future empirical investigation and analysis.
Flagellar assembly in Caulobacter crescentus: a basal body P-ring null mutation affects stability of the L-ring protein

The P- and L-rings are structural components of the flagellar basal body that are positioned in the periplasmic space and outer membrane, respectively. In order to explore the mechanism of P- and L-ring assembly, we examined the effect of a null mutation in the gene encoding the P-ring subunit, FlgI, on the expression, stability, and subcellular localization of the L-ring subunit, FlgH, in Caulobacter crescentus. Transcription of the L-ring gene and synthesis of the L-ring protein were both increased in the P-ring null mutant. However, steady-state L-ring protein levels were dramatically reduced compared with those of wild type. This reduction, which was not observed in flagellar hook mutants, was due to a decreased stability of the L-ring protein. The instability of the L-ring protein was apparent throughout the cell cycle of the P-ring mutant and contrasted with the fairly constant level of L-ring protein during the cell cycle of wild-type cells. Low levels of the L-ring protein were detected exclusively in the cell envelope of cells lacking the P-ring, suggesting that, in the absence of P-ring assembly, L-ring monomers are unable to form multimeric rings and are thus subject to proteolysis in the periplasm.
Clinical Action Curves:  Measuring the Magnitude of Physician Response to Abnormal Laboratory Results.

OBJECTIVES While reference limits are foundational to interpreting clinical laboratory tests, they may not correspond to the actual values triggering clinical response. We propose to measure this using clinical action curves, which plot test values against an indicator of clinical action. METHODS We selected repeat test ordering as a quantifiable, objective, useful measure that is readily calculable using available laboratory data. Using all results in Calgary in 2010-2011 for eight analytes, clinical action curves for each analyte were plotted as the relationship between index test value and retesting hazard, modeled using Cox proportional hazards with restricted cubic splines. Clinical action limits were defined where retesting hazard rose 38% above baseline (25%-50% considered). RESULTS In general, clinical action increased before the reference limits, and clinical action limits were narrower than reference limits. However, some reference limits showed no increased clinical action and may thus be ignored in practice. CONCLUSIONS Clinical action curves and limits provide practical, objective tools for describing physician responses to test values. Results suggest that many normal results are treated as abnormal and vice versa; such discrepancies require further scrutiny and ultimately reconciliation via altered reference ranges or altered practice patterns.
Views of logistics service providers on modularity in logistics services

The objective of this paper is to increase understanding of the concept of service modularity and to present examples of applications of modularity approach in logistics services. This aim is pursued with an empirical case study, consisting of interviews of 25 logistics service providers (LSPs). Themes found in the literature are used in the interviews and in the analysis of the interviews. The findings show that the LSPs consider modularity as a useful approach, and examples of applications of modularity can be found in the logistics industry. In the future, modularity thinking has potential to become a valuable tool for responding to the challenges facing the logistics service industry, as customers’ demands become increasingly diversified, and services, processes and organisational networks become more complex.
Age differences in intercorrelations between regional cerebral metabolic rates for glucose

Patterns of cerebral metabolic intercorrelations were compared in the resting state in 15 healthy young men (ages 20 to 32 years) and 15 healthy elderly men (ages 64 to 83 years). Controlling for whole‐brain glucose metabolism, partial correlation coefficients were determined between pairs of regional cerebral metabolic rates for glucose determined by positron emission tomography using [18F]fluorodeoxyglucose and obtained in 59 brain regions. Compared with the young men, the elderly men had fewer statistically significant correlations, with the most notable reductions observed between the parietal lobe regions, and between the parietal and frontal lobe regions. These results suggest that cerebral functional interactions are reduced in healthy elderly men.
Trust in the Board: A Strategic Imperative in Times of Uncertainty

ABSTRACT In turbulent environments, investors seek to minimize risk. Many public/nonprofit organizations evoke a sense of trust in their members by maintaining boards of directors. This study examined faculty member attitudes about the public/nonprofit institutions and boards who manage their retirement funds (n = 240). A structural model revealed that investors developed trust in the board when they view the organization positively through reliable communication, a sense of shared values and retirement funds that perform soundly. As a mediator of attitude toward the organization trust in the board also diminished investor perceptions of risk, and partially explained whether members cooperated and continued with the organization. The findings support trust as a key intervening factor in member-organization relationships and suggest building trust in board governance as an effective way to reduce uncertainty.
A Comparison of Finite Difference Schemes for Computational Modelling of Biosensors

Abstract. This paper presents a one-dimensional-in-space mathematical model o f an amperometric biosensor. The model is based on the reaction-diffus ion equations containing a non-linear term related to Michaelis-Menten kinetics of the enzym atic reactions. The stated problem is solved numerically by applying the finite diff rence method. Several types of finite difference schemes are used. The nu merical results for the schemes and couple mathematical software packages are compared a nd verified against known analytical solutions. Calculation results are compared in terms of the precision and computation time.
The chameleon of neuroinflammation: magnetic resonance imaging characteristics of natalizumab-associated progressive multifocal leukoencephalopathy

Natalizumab is a monoclonal antibody against α4-integrin approved for the treatment of multiple sclerosis (MS) due to a positive effect on clinical and magnetic resonance imaging (MRI) outcome measures. However, one relatively rare but serious side effect of this drug is a higher risk of developing progressive multifocal leukoencephalopathy (PML). Since the FDA approval, more than 300 natalizumab-associated PML cases have been documented among more than 100,000 treated MS patients. MRI is a crucial tool in the surveillance of patients treated with natalizumab in order to detect possible signs of PML in the asymptomatic stage. Although classical imaging characteristics of PML are well established, MRI findings in natalizumab-associated PML, particularly in early disease stages, show rather new and heterogeneous imaging findings including different patterns of inflammation with contrast enhancement. This review provides a comprehensive overview of the heterogeneous imaging findings in natalizumab-associated PML in the context of the underlying pathophysiology, histopathology, and the diagnostic procedure. We describe the MRI patterns of PML lesion evolution and complications including immune reconstitution inflammatory syndrome (IRIS). Finally, we present guidelines to differentiate MRI findings in PML from inflammatory demyelinating lesions, to facilitate the early diagnosis of PML in patients treated with natalizumab.
A Study of Market-Wide Short-Selling Restrictions

This paper contributes empirical evidence to the on-going debate on short sales. Our examination of how market-wide short-sale restrictions affect aggregate market returns focuses on two main questions: What is the effect of short-sale restrictions on skewness, volatility, the probability of market crashes, and liquidity? What is the effect on the market expected return or cost of capital? We report new data on the history of short-selling and put option trading regulations and practices from 111 countries, and create a short-selling feasibility indicator for the analysis of stock market indices around the world. We find that when short-selling is possible, aggregate stock returns are less volatile and there is greater liquidity. When countries start to permit short-selling, aggregate stock price increases, implying lower a cost of capital. There is no evidence that short-sale restrictions affect either the level of skewness of returns or the probability of a market crash. Collectively, our empirical evidence suggests that allowing short-selling enhances market quality.
A label‐free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen

In order to assess the biological function of proteins and their modifications for understanding signaling mechanisms within cells as well as specific biomarkers to disease, it is important that quantitative information be obtained under different experimental conditions. Stable isotope labeling is a powerful method for accurately determining changes in the levels of proteins and PTMs; however, isotope labeling experiments suffer from limited dynamic range resulting in signal change ratios of less than ∼20:1 using most commercial mass spectrometers. Label‐free approaches to relative quantification in proteomics such as spectral counting have gained popularity since no additional chemistries are needed. Here, we show a label‐free method for relative quantification based on the TIC from peptide MS/MS spectra collected from data‐dependent runs can be used effectively as a quantitative measure and expands the dynamic range over isotope labeling experiments allowing for abundance differences up to ∼60:1 in a screen for proteins that bind to phosphotyrosine residues.
A service science approach for improving healthy food experiences

Purpose – Insufficient attention to the specific nature of healthy food experiences might limit the success of related innovations. The purpose of this article is to adopt a value-in-use perspective to conceptualize healthy food consumption as experiential and emotional, rather than the mere intake of nutrition, and to examine the development of healthy food communication with a service science approach. Design/methodology/approach – With a service science approach, this study proposes a virtual healthy food platform for children. The key data come from internal project documents, workshops with children and other stakeholders (e.g. parents, teachers), and interviews with project team members. Findings – The simultaneity of functional and hedonic benefits, implications for multiple stakeholders, social norms, and need for expertise characterize healthy food experiences. The proposed framework accounts for enablers, principles, outcomes, and challenges affecting the development of communication integral to healthy food experiences, using project data and tools as illustrations. Research limitations/implications – This study contributes to growing literature on service science by introducing key principles and contingency factors that influence the success of experience-centric service innovations. Quantitative research should validate the established framework and investigate the elements’ relative usefulness for developing healthy food communication. Practical implications – The service science approach involves multiple stakeholders, empathic data collection, and visual tools to develop an entertaining platform to help children learn about healthy food. Originality/value – This research conceptualizes and validates healthy food experiences as value-in-use offerings. The proposed service science approach accounts for the interactions among stakeholders, the holistic nature, and specificities of a real-life decision context for improving healthy food experiences.
Uncovering the Outcomes of Equity Crowdfunding: Post-Funding Outcomes of Equity Crowdfunded Firms in Europe

The aim of this study is to explore the previously unresearched outcomes of firms funded through equity crowdfunding, a novel type of entrepreneurial finance. We study the outcomes of a sample of 337 firms funded on equity crowdfunding platforms in Europe between 2009 and 2014. By incorporating a descriptive statistics analysis, we discover the post-funding outcomes of the firms and complement this by a regression analysis in order to assess whether those outcomes can be attributed to equity crowdfunding campaign-related factors. A main finding is that the firms experience on average a peak in both sales and sales growth the year after the campaign and that this tends to be positively impacted by a larger number of investors through the campaign. Profit is on average found to decrease the years following the campaign, but with a less negative growth rate. The latter is positively impacted from having business angels investing through the campaign and a higher equity share offered. A similar pattern to those growth outcomes has been found when comparing the equity crowdfunded firms to firms funded by business angels, supporting the idea that business angel investing can be seen as an analogue to equity crowdfunding. We find that another common outcome is a PR effect, which is also positively impacted by the number of investors, and supports previous findings on crowdfunding showing that campaigns act as a marketing and promotional tool for firms.
The Persistence of the Performance in Stock Recommendations of Superior Sell-Side Analysts

The paper tests the performance of the superior analysts of the new fortune using the event study. The results show that the superior analysts perform better than the ordinary analysts generally and the difference between them is significant. But it is not that all of the superior analysts perform better than the ordinary analysts, the difference between the superior analysts who perform best and the superior analysts who perform worst is significant. And we find that the analysts express some continuity, the superior analysts who performed well in the past also perform well in the future. Our results show that it is not that all of the superior analysts of the new fortune are valuable for following and the investors would not blindly follow the superior analysts. Index Terms - The Superior Analysts; The Profitability; The Persistence
Effects of tamoxifen and exemestane on cognitive functioning: a study in postmenopausal breast cancer patients

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MODELING CREDIT RISK THROUGH CREDIT SCORING

Credit risk governs all financial transactions and it is defined as the risk of suffering a loss due to certain shifts in the credit quality of a counterpart. Credit risk literature gravitates around two main modeling approaches: the structural approach and the reduced form approach. In addition to these perspectives, credit risk assessment has been conducted through a series of techniques such as credit scoring models, which form the traditional approach. This paper examines the evolution of these initiatives.
UHF/UWB Tag Antenna of Circular Polarization

A dual-band circularly polarized (CP) tag antenna is presented in this paper, which combines ultrahigh-frequency (UHF) and ultrawideband (UWB) operations for radio-frequency identification (RFID) and high-precision localization applications. The proposed antenna consists of two CP radiating elements with separated ports, where the UHF element is a planar loop antenna loaded with two pairs of meander lines of different dimensions for compactness and CP radiation, while the UWB element is a modified Archimedean spiral antenna with a tapered metallization ratio and encircled by the UHF loop. In addition, a miniaturized shunt-stub is employed in the UHF element to realize conjugate matching between the antenna and the UHF RFID chip. Experimental characterization of a fabricated prototype has validated the design, which shows that the proposed antenna exhibits very good radiation performance at both the bands, with -10 dB power reflection bandwidths of 0.86-0.975 GHz and 2.6-12 GHz, and 3 dB axial-ratio bandwidths of 0.911-0.938 GHz and 3.1-11.1 GHz, respectively. This antenna can find applications in RFID and indoor positioning systems.
WILLINGNESS TO PAY FOR WATERSHED PROTECTION BY DOMESTIC WATER USERS IN TUGUEGARAO CITY, PHILIPPINES

Over the years, policy makers have explored various mechanisms, which address environmental management and poverty alleviation. Payments for environmental services (PES) is a relatively new concept which is now recognized as a way to address both of these goals. In a PES system, those who benefit from the environmental services (ES) compensate those who provide these services in order to secure ES provision. This paper investigates the value that domestic water users in Tuguegarao City place on watershed protection. Using the Contingent Valuation Method (CVM), this study established the willingness to pay of domestic water users in Tuguegarao City. Payments would contribute to a fund that would provide for the watershed protection of the Penablanca Protected Landscape and Seascape (PPLS). This would help to ensure the provision of a reliable water supply for their households. This local fund may lead to funding for a possible watershed management program. This would generate solutions to forest problems by directing funding support to upstream communities to implement measures protecting the PPLS.
Recruitment of Phosphoinositide 3-Kinase Defines a Positive Contribution of Tyrosine Kinase Signaling to E-cadherin Function*

Classical cadherin adhesion molecules can function as adhesion-activated cell-signaling receptors. One key target for cadherin signaling is the lipid kinase phosphoinositide (PI) 3-kinase, which is recruited to cell-cell contacts and activated by E-cadherin. In this study, we sought to identify upstream factors necessary for E-cadherin to activate PI 3-kinase signaling. We found that inhibition of tyrosine kinase signaling blocked recruitment of PI 3-kinase to E-cadherin contacts and abolished the ability of E-cadherin to activate PI 3-kinase signaling. Tyrosine kinase inhibitors further perturbed several parameters of cadherin function, including cell adhesion and the ability of cells to productively extend nascent cadherin-adhesive contacts. Notably, the functional effects of tyrosine kinase blockade were rescued by expression of a constitutively active form of PI 3-kinase that restores PI 3-kinase signaling. Finally, using dominant negative Src mutants and Src-null cells, we identified Src as one key upstream kinase in the E-cadherin/PI 3-kinase-signaling pathway. Taken together, our findings indicate that tyrosine kinase activity, notably Src signaling, can contribute positively to cadherin function by supporting E-cadherin signaling to PI 3-kinase.
Privatization and Entrepreneurial Transformation: The Role of Developmental Financial Institutions

With ongoing privatization efforts in emerging economies, governments have supported developmental financial institutions (DFI) to spur entrepreneurial activity in the absence of private venture capitalists. DFIs are quasi-governmental financial institutions with independent managerial control that often act within the constraints of a rapidly changing environment to support and accelerate privatization. In spite of their critical role in economic transformation, DFIs have received little attention in the management literature. We draw on two theoretical frameworks to develop an initial process model of DFI involvement with privatized firms in emerging economies. First, we use stakeholder theory to argue that post-privatization stakeholders differ in their motives to initiate organizational restructuring which is required for drawing DFI support. Second, we evoke the relational view of the firm to posit that DFI involvement generates relational rents that create value for the privatized entity. We discuss theoretical implications of including DFIs in privatization and management research in the emerging economy context.
Loyal customer discriminant model using customer features on EC site

In this study, we try to measure customer loyalty attract high attention from the viewpoint of customer relationship management (CRM). From this scape there are a few studies to measure the loyalty of the customers. However, these studies have not considered the potential customer features. In this study, we focus on EC site, then we additionaly consider the behavior out of the site as well as the behavior in the site for a customer. By doing so, we caught a wide variety of customer behavior by adding the behavior data out of the site and could identify a loyal customer more appropriately. In this study, we propose a model which is able to classify a loyal customer to discover a customer who has high loyalty to the EC site. For modeling, we used the behavior data out of the EC site in addition to RFM (Recency, Frequency, Monetary) gotten from purchasing data. In addition, based on the result of the precedent study, we adopted logistic regression to analyze the purchasing history of the loyal customer identified in the discriminant model. We try to grasp the purchasing tendency of a customer having high loyalty by analyzing the purchasing data of the loyal customer. In this study, We classified loyal customer into 3 classes Customer-A, Customer-B or Customer-C. We compared the precision by the RFM model and the our RFMO model. As a result, RFMO model can more classify loyal customer and the other customer with high precision compared with RFMmodel about Customer-A and Customer-B. In addition, it was shown that purchasing tendencies is difference at each loyal customers.