Miracle-dz/UniFAR-FTUs huggingface dataset:
The mei3 region of the Schizosaccharomyces pombe genome

Expression of the mei3 gene is sufficient to induce meiosis in the fission yeast Schizosaccharomyces pombe. The mei3 gene is located 0.64 Mb from the telomere of the left arm of Sz. pombe chromosome II. We have sequenced and analysed 107 kb of DNA from the mei3 genomic region. The sequence includes 14 known genes (bag1‐B, csh3, dps1, gpt1, mei3, mfm3, pac1, prp31, rpl38‐1, rpn3, rti1, spa1, spm1 and ubc4) and 26 other open reading frames (ORFs) longer than 100 codons: a density of one protein‐coding gene per 2.7 kb. Twenty‐one of the 40 ORFs (53%) have introns. In addition there is one lone Tf1 transposon long terminal repeat (LTR), tRNATrp and tRNASer genes and a 5S rRNA gene. 14 of the novel ORFs show sequence similarities which suggest functions of their products, including a coatomer α‐subunit, a catechol O‐methyltransferase, protein kinase, asparagine synthetase, zinc metalloprotease, acetyltransferase, phosphatidylinositol 4‐kinase, inositol polyphosphate phosphatase, GTPase‐activating protein, permease, pre‐mRNA splicing factor, 20S proteasome component and a thioredoxin‐like protein. One predicted protein has similarity to the human Cockayne syndrome protein CSA and one with human GTPase XPA binding protein XAB1. Three ORFs are likely to code for proteins because they have sequence similarity with hypothetical proteins, three encode predicted coiled‐coil proteins and four are sequence orphans. The sequence is derived from cosmid clones c4664, c119 and c557 and has been submitted to the EMBL database under Accession Nos AL591302, AL022117, AL110506 and AL023634 (part). Copyright © 2002 John Wiley & Sons, Ltd.
Examining the Reproducibility of Using Dynamic Loop Scheduling Techniques in Scientific Applications

Reproducibility of the execution of scientific applications on parallel and distributed systems is a growing concern, underlying the trustworthiness of the experiments and the conclusions derived from experiments. Dynamic loop scheduling (DLS) techniques are an effective approach towards performance improvement of scientific applications via load balancing. These techniques address algorithmic and systemic sources of load imbalance by dynamically assigning tasks to processing elements. The DLS techniques have demonstrated their effectiveness when applied in real applications. Complementing native experiments, simulation is a powerful tool for studying the behavior of parallel and distributed applications. In earlier work, the scalability [1], robustness [2], and resilience [3] of the DLS techniques were investigated using the MSG interface of the SimGrid simulation framework [4]. The present work complements the earlier work and concentrates on the verification via reproducibility of the implementation of the DLS techniques in SimGrid-MSG. This work describes the challenges of verifying the performance of using DLS techniques in earlier implementations of scientific applications. The verification is performed via reproducibility of simulations based on SimGrid-MSG. To simulate experiments selected from earlier literature, the reproduction process begins by extracting the information needed from the earlier literature and converting it into the input required by SimGrid-MSG. The reproducibility study is carried out by comparing the performance of SimGrid-MSG-based experiments with those reported in two selected publications in which the DLS techniques were originally proposed. While the reproduction was not successful for experiments from one of the selected publications, it was successful for experiments from the other. This successful reproduction implies the verification of the DLS implementation in SimGrid-MSG for the considered applications and systems, and thus, it allows well-founded future research on the DLS techniques.
The Determinants of Nicaraguan Nonagricultural Exporters: A Firm-Level Perspective

ABSTRACT Nicaragua, as a small emerging market with a challenging history of economic and political turmoil, is understudied within the international business context. Utilizing the World Bank's 2010 Nicaragua Enterprise Survey, this article explores which nonagricultural Nicaraguan firms are best suited to export. Important findings include firm location, firm size, ownership composition, performance, firm industry, firm quality programs, and firm origin in the informal sector. These findings are discussed within the Nicaraguan context.
Does Electricity Consumption have Significant Impact towards the Sectoral Growth of Cambodia? Evidence from Wald Test Causality Relationship

It is recognized that energy-output relationship studies from an economic perspective have become popular among researchers recently. This study deals with the electricity consumption and outputs of some major economic sectors in Cambodia. The newly developed ARDL bound testing approach has been employed to examine the cointegration relationship. The Granger causality test of the aforementioned ARDL framework has also been used to investigate the corresponding causality effect. Analysis and discussion based on the data of Cambodia, for the period of 1980 to 2010, are presented. Interestingly, there is no any cointegration relationship identified between electricity consumption and sectoral outputs. But, causality effect has been identified from electricity consumption towards the sectoral outputs. Based on the findings, few recommendations have been made in the hope of systematizing the energy more efficiently within the scrutinized sectors.
Antibiotic treatment of symptomatic Mycoplasma genitalium infection in Scandinavia: a controlled clinical trial

Objectives: To evaluate the microbiological cure rate after treatment with tetracyclines or azithromycin in patients infected with M genitalium. Methods: One hundred and fifty-two men and 60 women positive for M genitalium were recruited. Patients treated either with doxycyline for 9 days or with azithromycin 1 g stat. were compared. Those still positive for M genitalium after primary doxycycline treatment received an extended course of azithromycin 500 mg on day 1 followed by 250 mg daily for the following 4 days, whereas those with treatment failure after azithromycin received doxycycline 100 mg twice daily for 15 days. Results: The eradication rate after azithromycin 1 g stat. was 85% (95% CI 69 to 94) in men (n = 39) and 88% (95% CI 64 to 99) in women (n = 17) and after doxycycline 17% (95% CI 9 to 27) in men (n = 76) and 37% (95% CI 19 to 58) in women (n = 27). Extended azithromycin eradicated M genitalium from 96% (95% CI 85 to 99) of the men (n = 47) and from all six women who failed on doxycycline. Extended doxycycline treatment was insufficient. Persistent urethral inflammation was seen in a substantial portion of the men after eradication of M genitalium regardless of the antibiotic drug, indicating a poor predictive value of urethral smears in evaluation of persistent or recurrent infection. Conclusions: Azithromycin was more effective than doxycycline in treating patients infected with M genitalium. The extended course of azithromycin was highly effective but was given after the initial treatment with doxycycline. Randomised clinical trials are needed to compare the different dosages of azithromycin.
A simple, structural, and empirical model of the antipodean transmission mechanism

This paper studies the transmission of business cycles and the sources of economic fluctuations in Australia and New Zealand by estimating a Bayesian DSGE model. The theoretical model is that of two open economies that are tightly integrated by trade in goods and assets. They can be thought of as economically large relative to each other, but small with respect to the rest of the world. The two economies are hit by a variety of country‐specific and world‐wide shocks. The main findings are that the pre‐eminent driving forces of antipodean business cycles are worldwide technology shocks and foreign, i.e. rest‐of‐the‐world, expenditure shocks. Domestic technology shocks as well as monetary policy shocks appear to play only a minor role. Transmission of policy shocks is asymmetric, and neither central bank is found to respond to exchange rate movements. The model can explain 15% of the observed exchange rate volatility.
Framing behavioural approaches to understanding and governing sustainable tourism consumption: beyond neoliberalism, “nudging” and “green growth”?

Three different sets of approaches to understanding behaviour with respect to sustainable tourism mobility and consumption are identified in this paper: the utilitarian, social/psychological and the systems of provision/institutional approach. Each is based on different sets of assumptions on the factors that affect consumer sustainability behaviour. These assumptions not only affect the selection of policy tools to change behaviours but are also related to different modes of governance. Assumptions with respect to human behaviour and behavioural change and modes of intervention and governance are interrelated and mutually reinforcing and act as policy paradigms. Failure to recognise the importance of social structures in affecting behaviour has created a path dependency in which solutions to sustainable tourism mobility are only accepted within the dominant governance and behavioural paradigm. Other policy options and academic research that identify structures and institutions in systems of provision as a sustainability problem that requires non-market intervention and/or significant system change are regarded as marginal to the policy process or are ignored. It is concluded that all three different ways of approaching consumer behaviour are required if a sustainable transition to the socio-technological system of tourism mobility is to be made in a timely manner.
Natural variation of histone modification and its impact on gene expression in the rat genome

Histone modifications are epigenetic marks that play fundamental roles in many biological processes including the control of chromatin-mediated regulation of gene expression. Little is known about interindividual variability of histone modification levels across the genome and to what extent they are influenced by genetic variation. We annotated the rat genome with histone modification maps, identified differences in histone trimethyl-lysine levels among strains, and described their underlying genetic basis at the genome-wide scale using ChIP-seq in heart and liver tissues in a panel of rat recombinant inbred and their progenitor strains. We identified extensive variation of histone methylation levels among individuals and mapped hundreds of underlying cis- and trans-acting loci throughout the genome that regulate histone methylation levels in an allele-specific manner. Interestingly, most histone methylation level variation was trans-linked and the most prominent QTL identified influenced H3K4me3 levels at 899 putative promoters throughout the genome in the heart. Cis- acting variation was enriched in binding sites of distinct transcription factors in heart and liver. The integrated analysis of DNA variation together with histone methylation and gene expression levels showed that histoneQTLs are an important predictor of gene expression and that a joint analysis significantly enhanced the prediction of gene expression traits (eQTLs). Our data suggest that genetic variation has a widespread impact on histone trimethylation marks that may help to uncover novel genotype–phenotype relationships.
Engage Them to Public Service

This article deals with the emerging concept of Employee Engagement (EE) and its meaning for public administration research and theory. Generically, EE reflects a positive, fulfilling, affective-motivational, work-related state of mind characterized by vigor, dedication, and absorption. In an attempt to understand whether the concept of EE is meaningful for public administration research and theory, we examine its essence and foundation using a comparative method. First, we compare EE with two well-established employee–organization relationship (EOR) concepts: Affective Commitment (AC) and Job Involvement (JI). Second, we compare EE in public versus private sector employees, and finally, we compare the concept in employees and managers in the public sector. Our study is based on an interactive sample of 593 employees and managers from both the private and public sectors in Israel. The results support several hypotheses. First, EE is an empirically distinct construct compared with other EOR concepts. Second, EE is higher among public sector employees than private sector employees. Third, EE is higher among public managers than public employees. Implications of our findings and recommendations for future theoretical and empirical studies of EE are discussed.
Application of Modified BLP Model on Mobile Web Operating System

BLP model is a classic model of significant strategies of confidentiality. By classifying and marking the subjects and objects, it realizes the discretionary access control and mandatory access control. Existing system security models are mainly based on the improved BLP model. Along with the popularity of mobile devices, cross-platform system based on Web is attracting more and more attentions. For its advantages of high mobility, portability and scalability, Web OS is applied as mobile e-government system solution. However, the existing Web OSes provides low confidentiality, as well as ambiguous design of system security access control policy. Thus, they cannot satisfy the demands for the security of mobile egovernment system. This paper constructs the security model based on the analysis of BLP model, which achieves the abstract modeling of Web OS on intelligent terminal, and redefines the model elements, mapping functions, as well as access control policy on both the subject and object to improve its confidentiality. Since BLP model lacks the least privilege principle on trusted subject and integrity constraints, we redraw the security level of the subject and object, and add the tag of confidence level and role mapping function according to the existing Web OS model. Finally, we carry out the principle of least privilege, as well as the integrity constraints on subjects and isolation mechanism between domains, which can improve the security effectively.
A weighted least squares approach for multi-target Doppler-only localization

In this paper a multi target Doppler-only tracking scheme as well as its related algorithms are proposed and analyzed. Specifically the Doppler-only single target localization is firstly addressed in an heteroscedastic environment exploiting a weighted least square approach. Then this approach is extended to a multi target case introducing an algorithm to solve the inherent measurements to targets association problem. Finally the integration of these algorithms with a Kalman filter based tracking stage is analyzed and evaluated through simulations.
A Combined Analytic Hierarchy Process and Goal Programming Approach to International Portfolio Selection in the Presence of Investment Barriers

The aim of this paper is to develop an integrated multiple criteria decision making approach combining the analytic hierarchy process (AHP) and the goal programming (GP) model to study the impact of a mixture of investment barriers on international portfolio selection, and therefore the home bias puzzle from the viewpoint of G-7 investors over the period 2001-2009. The AHP is used to determine the suitable international equity portfolios with respect to seven barriers to international investment. The GP model, incorporating the market weights of the maximum return, minimal variance, and AHP portfolios is formulated to determine the optimal international equity portfolios. The main results show that the AHP-GP optimal international portfolio weights are different from those predicted by the I-CAPM. Also, except for French and US investors, home bias values determined according to the AHP-GP portfolios are lower than those calculated on the basis of the value-weighted world market portfolio.
Optimal Electricity Procurement in Smart Grids With Autonomous Distributed Energy Resources

Proliferation of private distributed energy resources (DERs) necessitates devising effective energy management frameworks. This paper aims at establishing a decentralized model for the optimal dispatch of DERs in smart grids. The objective function is to minimize expected procurement cost of demand while profit of private DER owners is not sacrificed. Unit management modules (UMMs) embedded in private DERs and a central agent are autonomous agents of the model. The approach is iterative. In each iteration, the central agent announces to UMMs its procurement strategy, which contains purchased powers and their prices. Then, UMMs optimize and send back their output power and selling price proposals in the hope of achieving higher profits. The energy service provider (ESP) gathers the bids and modifies the procurement strategy whenever bids are in line with the cost minimization objective. The service provider releases the last procurement strategy in response to which UMMs synchronously update and send back their bids. The mutual interaction between UMMs and ESP is continued to the point in which no further modification in ESP's procurement strategy is experienced. The effectiveness of the proposed algorithm is demonstrated by its implementation in a system with a few DERs from different types.
Molecular diagnosis of bacterial endocarditis by broad-range PCR amplification and direct sequencing

Broad-range PCR amplification of part of the 16S rRNA gene followed by single-strand sequencing was applied to samples of 18 resected heart valves from patients with infective endocarditis. The PCR results were compared with those of cultures of valves and with those of previous blood cultures. For two patients there was agreement with the cultures of the valves; for nine patients there was agreement with the previous blood cultures, which were positive, while the cultures of the valves were negative; a Streptococcus sp. and Tropheryma whippelii each were found in one patient with negative cultures (valve and blood); for two patients the cultures of the valves as well as the PCR results were negative but the blood cultures were positive; for one patient amplification was inhibited; and for two patients the PCR results were positive but the amplicons could not be sequenced. It is concluded that broad-range PCR is a promising tool for patients with culture-negative endocarditis and allows the detection of rare, noncultivable organisms.
A systolic architecture for labeling the connected components of multi-valued images in real time

A system capable of labeling the connected components of multi-valued images at video rates is described. The technique uses a simple linear systolic array to modify the labels of recently visited pixels in a raster scan. The array removes the need for the complex processing of label equivalence tables used in previous algorithms. A two-pass system is designed using the same custom VLSI chip for both passes with minimal support circuitry. This has an advantage over previous hardware implementations where more complex algorithms require separate hardware modules for each pass. <<ETX>>
Equal Opportunities in Education: Market Equilibrium and Public Policy

This paper investigates whether individual decisions lead to equality of opportunity in education, defined in the specific sense of irrelevance of parental income for university attendance. We show that, even if households can borrow in the capital market, the laissez-faire equilibrium exhibits an income bias, in the sense that individuals from high income households are more likely to attend university. We then study the welfare maximising policy of a utilitarian government. Its features are opposite to the free market equilibrium: with plausible assumptions, at low income levels, the tuition fee should be designed in such a way so as to create a bias in favour of low income households.
Decentralization, Performance Evaluation and Government Performance

In order to improve the organizational performance of governmental entities, there has been a tendency in many countries to introduce management reforms that are believed to prevail in private companies. The term 'NPM' (New Public Management) was coined to label these reforms. NPM stresses - among many other things - that public services have to be rationalized and emphasis put on quantification as a means of demonstrating achievements (efficiency gains, new levels of performance) and of holding responsible people accountable. In the Netherlands, many municipalities have adopted NPM reforms. This paper considers the results of these NPM reforms. In particular, it focuses on two reforms: the decentralization of decision making authority to middle managers and the greater emphasis on accounting criteria for performance evaluation. This research explores whether managers are indeed motivated by such measures using a contingency-type approach. In this paper, the survey data (214 observations) are analyzed by using Partial Least Squares (PLS). The analysis shows that the performance evaluation system of municipal departments is hardly related to the level of decentralization. Furthermore, it is shown that the effect of the use of accounting performance measures for evaluation purposes on the performance is moderated by the level of environmental uncertainty: the use of these accounting criteria results in more goal clarity at higher levels of uncertainty. However, we also found that managers are more concerned about their performance evaluation in these circumstances. These findings confirm the claim of Hartmann (2000) that environmental uncertainty may have multiple effects. Organic processes are found to be an important moderator: especially open communication increases the positive effects of using accounting performance measures at higher levels of environmental uncertainty and it mitigates the negative effects. The use of objective nonfinancial indicators (such as indicators expressing the quality of services) overall has a positive effect. For the use of subjective nonfinancial indicators we found opposite effects. Finally, we show that goal clarity of the managers and agreement on evaluation criteria are positively related to the performance of municipal departments.
Pragmatist Perspective on Knowledge and Knowledge Management in Organizations

Three main schools of thought about knowledge and knowledge management are positivism, non-positivism, and pluralistic perspective. Their conflict about what knowledge is and what knowledge management endures without concluding end. This article contributes to the literature by arguing for a different perspective that helps solve this conflict: pragmatism. Knowledge, for pragmatists, is outcome of inquiry, with the chief value being its usefulness. From this perspective, we argue for a reflective knowledge management approach, which requires knowing people and people in charge of the knowledge management function to have an attitude of being that is called knowledge responsibility.
Deadtime Compensation for Model Predictive Control of Power Inverters

When employed as a modulator in power inverters, model predictive control has an equivalence to a recently proposed modulation technique known as feedback quantizer modulation (FBQM). Both schemes produce a random-like switching pattern that can facilitate explicit control over the shape of frequency spectra associated with inverter output voltages and currents. This is useful to satisfy electromagnetic interference and acoustic noise requirements, and to avoid excitation of external system resonances. However, it will be shown in this paper that inverter deadtime introduces a disturbance into FBQM that significantly degrades the ability to shape the frequency spectra. Several compensation techniques, designed to model the effect of deadtime inside the formulation of FBQM, are proposed and experimentally verified on a two-level three-phase inverter.