Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic stabilization of technological systems for processing edge cutting through local metastability

The treatment of complex products from hard materials is accompanied by loss of stability of the cutting process, which leads to oscillations which cause an increase in the wear rate of cutting tools, reducing the longevity of the machine actuators, which ultimately affects the quality and accuracy of processing responsible products. The development of a framework for reducing the intensity oscillations in the process of machining systems, software and algorithmic software for computer solution, allows solving the problem of automation and process control by edge cutting machining on machine tools, such as CNC.
Segmentation of Ohio's Logging Industry Based on Productivity and Cost Variables

The objective of this research was to develop baseline information regarding the structure and performance of Ohio’s logging industry. Questionnaires were distributed on-site at logger chapter meetings across the state. Multivariate clustering was used to group similar types of firms based on responses to 15 productivity and cost variables. Three clusters were identified: Local Mill Suppliers, Product Merchandisers, and Volume-Dependent Producers. The clusters were largely homogeneous as far as the overall makeup and administration of their companies. Clusters did differ regarding haul distance, pieces of equipment owned, and equipment age. Volume-Dependent Producers, while not significantly larger in size statistically, viewed the productivity, present, and future cost variables more pessimistically than the other clusters. The key variable of concern across clusters was the cost of consumables, primarily fuel, paralleling more recent findings in other states.
An approach to multiple Change Detection in multisensor VHR optical images based on iterative clustering

When dealing with optical images, the most common approach to unsupervised change detection is Change Vector Analysis (CVA) which computes the multispectral difference image and exploits its statistical distribution in (hyper-)spherical coordinates. The latter step usually requires assumptions on both the model of class distributions and the number of changes. However, both assumptions are seldom satisfied especially when multisensor VHR images are considered. Thus, we propose an approach to multiple change detection in multisensor VHR optical images based on iterative clustering in (hyper-) spherical coordinate. The proposed approach is distribution free, unsupervised and automatically identifies the number of changes. Results obtained on a multitemporal and multisensor dataset including images from WorldView-2 and QuickBird are promising.
Non‐equivalent roles of two periplasmic subunits in the function and assembly of triclosan pump TriABC from Pseudomonas aeruginosa

In Gram‐negative bacteria, multidrug efflux transporters function in complexes with periplasmic membrane fusion proteins (MFPs) that enable antibiotic efflux across the outer membrane. In this study, we analyzed the function, composition and assembly of the triclosan efflux transporter TriABC–OpmH from Pseudomonas aeruginosa. We report that this transporter possesses a surprising substrate specificity that encompasses not only triclosan but the detergent SDS, which are often used together in antibacterial soaps. These two compounds interact antagonistically in a TriABC‐dependent manner and negate antibacterial properties of each other. Unlike other efflux pumps that rely on a single MFP for their activities, two different MFPs, TriA and TriB, are required for triclosan/SDS resistance mediated by TriABC–OpmH. We found that analogous mutations in the α‐helical hairpin and membrane proximal domains of TriA and TriB differentially affect triclosan efflux and assembly of the complex. Furthermore, our results show that TriA and TriB function as a dimer, in which TriA is primarily responsible for stabilizing interactions with the outer membrane channel, whereas TriB is important for the stimulation of the transporter. We conclude that MFPs are engaged into complexes as asymmetric dimers, in which each protomer plays a specific role.
3‐Methylindole production is regulated in Clostridium scatologenes ATCC 25775

Aims: 3‐Methylindole (3‐MI) is a degradation product of l‐tryptophan and is both an animal waste malodorant and threat to ruminant health. Culture conditions influencing 3‐MI production in Clostridium scatologenes ATCC 25775 were investigated.
Adaptive Coherency Matrix Estimation for Polarimetric SAR Imagery Based on Local Heterogeneity Coefficients

Polarimetric synthetic aperture radar (SAR) images usually contain a mixture of homogeneous and heterogeneous regions, which makes estimation of the coherency matrix a very challenging task. In this paper, we propose an adaptive coherency matrix estimation method that employs local heterogeneity coefficient and leverages the sample covariance matrix estimation to the homogeneous components and the fixed-point estimation to the heterogeneous components. Evaluations were conducted with synthetic polarimetric data and real-world SAR imagery, including UAVSAR, RADARSAT-2, and ESAR. Our experimental results demonstrated that the heterogeneity coefficient effectively characterizes the scattering property of ground objects, which enables adaptive estimation of the coherency matrix in high-resolution polarimetric SAR imagery. Our method was able to handle single- and multilook polarimetric SAR imagery gracefully. Compared with the sample covariance matrix estimator, the fixed-point estimator, and the Lee sigma filtering, our method achieved the best performance for retaining the spatial structure, suppressing speckles, and preserving polarimetric information of SAR imagery with different degrees of heterogeneity.
New Frontiers in Ambulatory Assessment

With the increasing use of smartphone technologies and wearable biosensors, we are currently undergoing what many have termed a “data revolution,” where intensive, multichannel data are passively collected over long time frames. Such procedures are transforming the way psychologists conceptualize research and have the potential to spur important advances in the study of close relationships. This proof-of-concept study from the Couple Mobile Sensing Project, a partnership between psychologists and engineers, combines big data and ambulatory assessment methodologies to study multimodal, microprocesses in couples’ everyday lives. These data collection procedures are designed to test how characteristics of everyday behavioral, physiological, and vocal interactions are integrated within and across individuals. We present two mini-illustrations to show how these data can be synchronized across modalities and partners and can be linked to generalized relationship dimensions. Discussion highlights the potential and challenges of capturing multimodal, multiperson, real-time, naturally occurring social phenomena.
Exploitation and Exploration Balanced Hierarchical Summary for Landmark Images

While we have made significant progress over image understanding and search, how to meet the ultimate goal of satisfying both exploration and exploitation in one single system is still an open challenge. In the context of landmark images, it means that a system should not only be able to help users to quickly locate the photo they are interested in (exploitation), but also to discover different parts of the landmark which have never been seen before (exploration), which is a common request as evidenced by many recent multimedia studies. To the best of our knowledge, existing systems mainly focus on either exploration (e.g., photo browsing) or exploitation (e.g., representative photo identification), while users' need of exploration and exploitation is dynamically mixed. In this paper, we tackle the challenge by organizing landmark images into a hierarchical summary which gives user the flexibility of conducting both exploration and exploitation. In the hierarchical summary construction, we introduce two principles: the coherence principle and the diversity principle. Behind these two principles, the intrinsic concept is “detail-level,” which measures how much detail that an image reflects for a certain landmark. A new objective function is derived from the definition of both exploration and exploitation experience on detail-level. The problem of finding an optimal hierarchical summary is formulated as searching over a space of trees for the one that achieves the best objective score. Extensive quantitative experimental results and comprehensive user studies show that the optimized hierarchical summary is able to satisfy both experiences simultaneously.
Prognostic role of the lymphocyte-to-monocyte ratio in patients undergoing resection for nonmetastatic rectal cancer

AbstractLymphocyte-to-monocyte ratio (LMR) was associated with survival benefit in some types of cancer. The relationship between LMR and rectal cancer has not been investigated. We conducted a retrospective cohort study to assess the prognostic significance of LMR in patients with nonmetastatic rectal cancer. Patients with rectal cancer who underwent potentially curative resection between January 2009 and December 2013 were enrolled. The LMR was calculated from preoperative blood test by dividing the absolute lymphocyte counts by the absolute monocyte counts. The optimal cut-off value for LMR was calculated as the median value. On the basis of the cut-off value, patients were divided into 2 groups: low group and high group. A total of 543 patients with rectal cancer were eligible for this study. The median follow-up time for all patients was 55 months (range 6–85 months). The cut-off value of LMR was 5.13 and patients were divided into 2 groups: low group (LMR < 5.13) and high group (LMR ≥ 5.13). In the univariate and multivariate analysis, the LMR was not significantly associated with overall survival (OS) [hazard ratio (HR): 1.034, 95% confidence intervals (CIs): 0.682–1.566, P = 0.876]. When disease-free survival (DFS) was compared, univariate and multivariate analysis also indicated that the LMR was not significantly associated with DFS (HR: 0.988, 95% CI: 0.671–1.453, P = 0.950). In addition, in the subgroup analysis by tumor-node-metastasis stage, there existed no significance between LMR and OS and DFS. Although as an easy access and highly efficient laboratorial inflammatory marker, LMR cannot predict the prognosis of nonmetastatic rectal cancer patients.
Bis{(E)-2-ethoxy-6-[2-(ethylammonio)ethyliminomethyl]phenolato}nickel(II) bis(perchlorate)

In the title centrosymmetric mononuclear nickel(II) complex, [Ni(C(13)H(20)N(2)O(2))(2)](ClO(4))(2), the Ni(II) atom is four-coordinated by the imine N and phenolate O atoms of the zwitterionic forms of two Schiff base ligands in a square-planar coordination geometry. In the crystal structure, mol-ecules are linked through inter-molecular N-H⋯O hydrogen bonds, forming chains running along the a axis.
Etude des populations immunitaires régulatrices et inflammatoires dans les cancers colorectaux

L'existence d'une immunite anti-tumorale a longtemps ete controversee. Aujourd'hui, de nombreuses etudes ont montre des reponses anti-tumorales specifiques. Les lymphocytes infiltrant la tumeur (TIL) jouent un role dans l'inhibition de la croissance des tumeurs et sont associes a un meilleur pronostic. Cependant, la presence d'une tumeur malgre le systeme immunitaire met en evidence des mecanismes d'echappement. J'ai tout d'abord participe a la caracterisation de la valeur pronostic de marqueurs lymphocytaires. La densite de l'infiltrat lymphocytaire T, en particulier les lymphocytes T memoires, et leurs localisations au niveau du centre et du front de progression de la tumeur sont associees au devenir clinique des patients. Ces parametres permettent une classification des patients a risque eleve de recidive bien plus significative que les parametres anatomopathologiques. En etudiant plus precisement ces parametres, nous avons montre l'alteration progressive des reponses immunitaires anti-tumorales lors de l'envahissement des ganglions ou d'organes a distance. Je me suis donc interessee aux marques de cytotoxicite en relation avec les differentes sous-populations T helper. Nous avons a nouveau trouve des clusters fonctionnels mais seuls les reponses Th1, cytotoxique et Th17 sont associees au pronostic des patients. Les patients avec une forte reponse Th1 ou cytotoxique sont de bon pronostic tandis que ceux avec une forte reponse Th17 sont de mauvais pronostic. La combinaison de ces parametres est plus discriminante pour determiner les patients a risque de recidive. Les microARNs interviennent dans de nombreux processus biologiques physiologiques (dont le systeme immunitaire) et physiopathologiques (dont le cancer). J'ai etudie leurs profils d'expression dans des colons sains et tumoraux. Ces profils sont differents, avec des sur-expressions et sous-expressions de certains microARNs. J'ai egalement observe l'association de certains microARNs au devenir clinique de patients mais aussi a des marqueurs du systeme immunitaire. L'ensemble des travaux realises montre l'importance de la reaction immunitaire adaptative pour l'etablissement du pronostic des patients atteints de cancers colorectaux. Son evaluation en routine permettrait de mieux orienter les patients vers une strategie therapeutique adaptee.
Secondary Degeneration of Nerve Tracts following removal of the Cortex of the Cerebrum in the Dog

IN a previous number of this Journal' a detailed account has been given of the extent of the cerebral lesion in a dog which had been operated on by Prof. Goltz. An account has also been given of the condition of the dog when it was shown at a Sectional Meeting of the International Medical Association in London in 18812; a Meeting which took place two and a half months after the last operation on the dog and shortly before it was killed. It is in the medulla oblongata and spinal cord of this animal that we have endeavoured to determine what nerve tracts had degenerated. We had at our disposal the spinal cord, from the second cervical nerve downwards, the right half of the spinal cord above this, and the right half of the medulla oblongata. The observations of previous observers have shown that removal, more or less extensive, of the 'motor area" of the cortex produces a certain amount of degeneration in the lateral pyramidal tract of the spinal cord from the cervical to the lumbar region. Since from this dog the cortex of the cerebral hemispheres bad been removed unequally on the two sides, and at different dates, we hoped that a comparison of the degeneration on the two sides of the cord, might lead to some conclusion as to whether removal of particular portions of the cortex, cause degeneration of particular parts of the lateral pyramidal tract of the spinal cord. It seemed also desirable to determine whether secondary degeneration had occurred in all parts of the crusta and pyramids or in certain parts only.
Skew-t partially linear mixed-effects models for AIDS clinical studies

ABSTRACT We propose partially linear mixed-effects models with asymmetry and missingness to investigate the relationship between two biomarkers in clinical studies. The proposed models take into account irregular time effects commonly observed in clinical studies under a semiparametric model framework. In addition, commonly assumed symmetric distributions for model errors are substituted by asymmetric distribution to account for skewness. Further, informative missing data mechanism is accounted for. A Bayesian approach is developed to perform parameter estimation simultaneously. The proposed model and method are applied to an AIDS dataset and comparisons with alternative models are performed.
Fatal Pulmonary Infection Associated with a Novel Organism, “Parastreptomyces abscessus”

ABSTRACT Actinomycetes are increasingly recognized as pathogenic in the immunocompromised host. We isolated an asporogenous, nonmotile, aerobic gram-positive rod from a transplant recipient with a fatal pulmonary infection. The pathology was similar to that associated with Rhodococcus equi, including intrahistiocytic localization. The organism was relatively inert in standard biochemical tests. 16S rRNA gene sequencing indicated a potentially unique organism most closely related to the genus Streptomyces, for which we propose the name “Parastreptomyces abscessus. ”
CELL-MEDIATED MITOGENIC RESPONSE INDUCED BY LEUKOAGGLUTININ AND L E N S C U L I N A R I S LECTIN IN MOUSE LYMPHOCYTES

This work was undertaken to characterize the response of mouse lymphocytes to a syngeneic stimulus after surface modification by lectins. As previously reported (1), cortisone-resistant thymocytes (CRT) 1 manifest a high proliferative response to syngeneic mitomycin-C-treated spleen cells (Mito-Sp) 2-3 days after the initiation of culture when either responder or stimulator is briefly pretreated with a supermitogenic dose of concanavalin A (Con A). The reaction is distinct from mitogenic response to soluble Con A and reveals that syngeneic cells can lead to T-cell activation when membranes have been modified by lectin binding. In the present work we report that two additional lectins, namely leukoagglutinin and Lens culinaris lectin (LcH) are capable of generating closely similar responses in mouse T cells. O'Brien et ah (2) and Beyer and Bowers (3) reported a comparable response in human and rat lymphocytes. They found that periodate-treated lymphocytes that had been inactivated with mitomycin-C stimulate a significant proliferative response in autologous untreated lymphocytes. Mills et al. (4) observed a similar lymphocyte activation generated by Con A pretreatment. Novogrodsky (5) reported that lymphocytes are stimulated by syngeneic cells that had been pretreated with neuraminidase and galactose oxidase. In these responses there was no evidence for a soluble mediator that could induce an equivalent response. Because of their common characteristics we speak of these reactions as cellmediated mitogenic responses (CMMR). The characteristics of CMMR were studied in two ways. First, various reagents were checked for their ability to produce CMMR. Results for 10 reagents including seven plant lectins are presented concerning (a) their ability to induce CMMR, (b) agglutinating, and (c) mitogenic properties. Second, we attempted to determine the cellular subpopulation that may act as responder and stimulator in CMMR. We asked whether specific cell combinations are necessary to generate the response. This question was studied with four different procedures.
Reflections on the historical, epistemological, and social meaning of technoscience

“France sustains today the best organized and most outspoken philosophical-ideological contestation of the conflation of science with technology”, according to historian of science and technology, Paul Forman, “in part because over the past three to four decades France has been the locus of the best organized and most outspoken philosophical-ideological advocacy of that conflation” (Forman, 2007, p. 6). The book under review, The dizzy heights of technoscience: shaping the world atom by atom, by the French philosopher, Bernadette Bensaude-Vincent (Professor of History of Science at Universidade de Paris I – Sorbonne), is an important contribution to this contemporary philosophical-ideological debate on recent changes of the science-technology relationship and, consequently, on the meaning of the concept of technoscience. In this debate, there are deep divisions between those who maintain that there are no significant differences between science and other forms of knowledge, especially technological knowledge, and those who recognize the specificity of science as both epistemological perspective and institutionalized practice of research (cf. Forman, 2007; Shinn & Ragouet, 2008). The book under review, however, like many other theoretical and empirical writings on the theme, cannot be easily fitted to one or other of these opposing poles. Bensaude-Vincent endorses the fusion of science and technology, ending up with a defense of the demystifying character of the concept of technoscience, and the necessity to surpass the dualisms of modern philosophical thought; but, she also criticizes many postmodernist ideas that often lie behind these views – she offers a postmodern position opposed to postmodernism. In this review, I will critically discuss the main lines of the author’s argument concerning: (1) the demystifying character of the concept of technoscience; (2) scientiae zudia, Sao Paulo, v. 10, special issue, p. 129-39, 2012 rview s
An SQP Augmented Lagrangian BFGS Algorithm for Constrained Optimization

In this research an effective algorithm for nonlinearly constrained optimization using the structured augmented Lagrangian secant update recently proposed by Tapia is presented. The algorithm is globally defined, and uses a new and reliable method for choosing the Lagrangian augmentation parameter that does not require prior knowledge of the true Hessian. Considerable numerical experimentation with this algorithm, both embedded in a merit-function line search SQP framework and without line search, is presented. The algorithm is compared to the widely used damped BFGS secant update of Powell, which, like the one in this paper, was designed to circumvent the lack of positive definiteness in the Hessian of the Lagrangian. It is also established that when the algorithm converges it converges R-superlinearly, which is a strong result in that it makes no assumptions on the approximate Hessian or the augmentation parameter. An immediate corollary is a new result in unconstrained optimization: whenever the uncons.
The Potential for Gut Organoid Derived Interstitial Cells of Cajal in Replacement Therapy

Effective digestion requires propagation of food along the entire length of the gastrointestinal tract. This process involves coordinated waves of peristalsis produced by enteric neural cell types, including different categories of interstitial cells of Cajal (ICC). Impaired food transport along the gastrointestinal tract, either too fast or too slow, causes a range of gut motility disorders that affect millions of people worldwide. Notably, loss of ICC has been shown to affect gut motility. Patients that suffer from gut motility disorders regularly experience diarrhoea and/or constipation, insomnia, anxiety, attention lapses, irritability, dizziness, and headaches that greatly affect both physical and mental health. Limited treatment options are available for these patients, due to the scarcity of human gut tissue for research and transplantation. Recent advances in stem cell technology suggest that large amounts of rudimentary, yet functional, human gut tissue can be generated in vitro for research applications. Intriguingly, these stem cell-derived gut organoids appear to contain functional ICC, although their frequency and functional properties are yet to be fully characterised. By reviewing methods of gut organoid generation, together with what is known of the molecular and functional characteristics of ICC, this article highlights short- and long-term goals that need to be overcome in order to develop ICC-based therapies for gut motility disorders.