Miracle-dz/UniFAR-FTUs huggingface dataset:
Prometastatic Effect ofN-Acetylglucosaminyltransferase V Is Due to Modification and Stabilization of Active Matriptase by Adding β1–6 GlcNAc Branching*

Oligosaccharide moieties of glycoproteins are structurally altered during development, carcinogenesis, and malignant transformations. It is well known that β1–6 GlcNAc branching, a product of UDP-GlcNAc α-mannoside β1–6-N-acetylglucosaminyltransferase (GnT-V), is associated with malignant transformation as the results of such alterations. However, the mechanism by which β1–6 GlcNAc branching is linked to metastasis remains unclear, because the identification of specific glycoprotein(s) that are glycosylated by GnT-V and its biological function have not been examined. We herein report that matriptase, which activates both urokinase-type plasminogen activator and hepatocyte growth factor, is a target protein for GnT-V. The overexpression of GnT-V in gastric cancer cells leads to severe peritoneal dissemination in athymic mice, which can be attributed to the increased expression of matriptase. This increase was due to the acquired resistance of matriptase to degradation, since it is glycosylated by GnT-V and a corresponding increase in the active form. These results indicate that this process is a key element in malignant transformation, as the direct result of oligosaccharide modification.
A Study on the Audit Times for Each Position and the Audit Risk: Focusing on the Accounting Firm Type

The purpose of this study is to analyze the decision factors of audit risk by using the audit times for each position announced in the audit. The sample of this study sets up a regression model that sets the audit times of each position classified as the dependent variable announced from FY2014 to FY2015 in DART, and as the independent variables and the control variables that can affect the audit risk. In the regression model, the audit time (log) of the registered accountant had the best explanation power. In the case that the audit time (log) of the registered CPA was used as the dependent variable, the audit time was found to significantly increase in the auditor designation company, the initial audit company, the company with high debt ratio, the company that received not the unqualified opinion either in this term or in the last term, and the company with a large natural log value of the total assets.
A Conceptual Review of Existing Models on Prediction of Corporate Financial Distress

Corporate Financial Distress has been a hot topic in research for more than eighty years. From the univariate model of Beaver (1966), and the Multivariate Discriminant Analysis model of Altman (1968) to models based on Logit, Probit, Artificial Neural Networks (ANN), Bayesian models, Fuzzy models, Genetic Algorithms (GA), Decision trees, Support vector machines, K-nearest neighbour, Hazard and Hybrid, model building has evolved during this period with the focus of enhancing prediction accuracy. Many models have been built using quantitative parameters. These models mainly used financial data of the company whilst there has been some models which has used macro variables and market variables in model building. There has been limited studies on models built using qualitative parameters of the company. The paper discusses the existing literature in the areas of predicting Corporate Financial Distress and concludes by providing future research directions on identified gaps.
Smart phone addiction and mindfulness: an intergenerational comparison

Young consumers are particularly vulnerable to the addictive nature of smart phone technology. This paper aims to investigate the smart phone addiction cycle and health outcomes of young and old consumers from the lens of consumers’ mindfulness traits. ,Qualitative and quantitative studies reveal that the lack of mindfulness, measured as a mindless trait, is strongly associated with smart phone addictions and health and quality of life outcomes. ,Differences in mindlessness and smart phone-generated health outcomes are found between younger and older consumers. The negative impact of mindlessness on quality of life was greater for younger adults than older adults. ,This research establishes baseline effects between the mindless trait and smart phone addiction levels. ,Paper suggests the marketing of mindfulness programs and the use of marketplace apps to combat addiction issues. ,Smart phone addiction is a growing problem, and this paper contributes to the understanding of the problem and offers societal solutions for its resolution. ,This is the first empirical paper to investigate the connection between a mindless trait and smart phone tendencies and resulting health outcomes.
BRAF mutation predicts for poor outcomes after metastasectomy in patients with metastatic colorectal cancer

BRAF mutations occur in 5% to 11% of patients with metastatic colorectal cancer (mCRC) and have been associated with poor prognosis. The current study was undertaken to determine the clinicopathologic characteristics, PIK3CA (phosphatidylinositol‐4,5‐bisphosphate 3‐kinase, catalytic subunit alpha) mutation frequency, and outcomes after metastasectomy in patients with BRAF‐mutant mCRC.
Bilateral (opercular and paracentral lobular) polymicrogyria and neurofibromatosis type 1

Anecdotal cases of polymicrogyria (PMG; a malformation of cortical development consisting of an excessive number of small gyri with abnormal lamination) in patients with neurofibromatosis type 1 (NF1) have been described; however, the cases were unilateral and had negative NF1 genetic testing. We describe an 11‐year‐old girl with NF1 manifesting as a complex epileptic syndrome, including partial seizures secondarily generalized and status epilepticus, who had in association, bilateral, asymmetrical (opercular and paracentral lobular) PMG. She had a 1‐bp deletion (c.1862delC) in exon 12b of the NF1 gene. It is notable that, given the key role played by the NF1 gene product, neurofibromin, in normal brain development, and the relatively high frequency of other brain findings in NF1, there are not more NF1 cases with brain malformations manifesting as PMG. © 2011 Wiley‐Liss, Inc.
Improving the Retailer Industry Performance Through RFID Technology: A Case Study of Wal-Mart and Metro Group

The purpose of this research study is to examine the improvement of supply chain performance through Radio Frequency Identification Technology (RFID). This research study focuses on RFID and its implementation at two retail chains Wel-Mart in United State (U.S.) and Metro Group in Europe who has successfully implemented this technology and identifies the impact of RFID on improving supply chain performance in the retail industry. The research study has examined a wide range of research literature and grey data. The researcher has concentrated on both explorative and indicative studies in an effort to understand the impact that the adoption of RFID technology will have on improving the performance of the supply chain by comparing two different case studies. This research study has found that coordination and integration operations are important for inventory management and related operations and they are also important factors which contribute to performance improvement in both case studies. In addition, this research study has found that RFID’s information-sharing support for buyers in the supply chain has promoted the accuracy of purchasing forecasts. Finally, it is found that RFID has provided increased flexibility of operations, using smart shelves and reducing the cost of inventory management.
Impact of supply chain collaboration and knowledge sharing on organizational outcomes in pharmaceutical industry of Bangladesh

Purpose This study aims to investigate the proposed relationships concerning the supply chain collaboration (SCC) practices and knowledge sharing with organizational performance in the pharmaceutical industry of a developing country. Design/methodology/approach In total, 203 executives working in various pharmaceutical companies of Bangladesh participated in the study. Factor analysis and structural equation modeling were applied to test the proposed research hypotheses. Findings This study reveals that both knowledge sharing and collaboration practices in the supply chain significantly influence customer satisfaction leading to business competitiveness as evidenced in the superior product quality and new product innovation in this knowledge-intensive industry. It further reveals a statistically significant correlation between SCC and knowledge sharing practices. Research limitations/implications This study is performed only on the manufacturers in the pharmaceutical industry from the perspective of a developing country. Future studies could cover other entities operating in a pharmaceutical supply chain. Practical implications The findings of the study have significant practical implications due to the fact that the aspect of knowledge sharing exerts influence on customer satisfaction that holds the key to competitive priorities. The managers need to address this issue seriously. Originality/value Few studies have been performed vis-a-vis the impact of both SCC and knowledge sharing on the organizational outcomes in the pharmaceutical industry from the perspective of a developing country.
Rapid population increase and urban housing systems : legitimization of centralized emergency accommodations for displaced persons

Sudden population influxes in cities place unexpected demands on the urban housing system. During these influxes, decisions made to accommodate displaced persons are often controversial, potentially hindering the ability of organizations involved to respond. Understanding how individuals within those organizations legitimize and delegitimize actions taken to accommodate internationally displaced persons is thus crucial to make decisions that will lead to efficient institutional responses. Existing research relating to the adaptation of urban housing systems for international population influxes in developed countries primarily focus on the long-term response rather than on the short-term response. This study seeks to address this research gap by providing an overview of the perspectives of stakeholders involved in the provision of centralized accommodations for displaced persons during the refugee crisis in 2015 in Germany. A qualitative analysis of interview data was performed to obtain a holistic understanding of the studied institutional response. Twenty-five interviews with employees involved in different steps of the process for providing centralized accommodations for displaced persons were conducted in 2016. Interview content was analyzed to capture the way stakeholders legitimized (1) the provision of centralized accommodations for displaced persons, and (2) the provision of specific types of accommodations commonly used. Results show that interviewed individuals mainly legitimized the process for providing centralized accommodations to displaced persons based on their individual convictions and by using procedural, consequential, influence and exchange legitimacy. They mainly delegitimized this process based on selfinterested calculations and by using exchange and influence legitimacy. Finally, results indicate that short-term accommodations, such as sport halls, were the least preferred option, while solutions such as modular housing and the renovation of unused buildings were the most preferred options. 1 Master Student, Department of Civil, Architectural and Environmental Engineering, Cockrell School of Engineering, the University of Texas at Austin, 301 E. Dean Keeton St. Stop C1700, Austin, TX, 78712, USA, Phone +1 512.201. 3003, julie.faure@utexas.edu 2 Assistant Professor, Department of Civil, Architectural and Environmental Engineering, Cockrell School of Engineering, the University of Texas at Austin, 301 E. Dean Keeton St. Stop C1700, Austin, TX, 78712, USA, Phone +1 512.475. 8059, faustk@utexas.edu 3 Assistant Professor, Civil and Environmental Engineering Department, University of Washington, 121H More Hall, Box 352700, Seattle, WA, 98195 USA, Phone +1 206.221. 3058, jkaminsk@uw.edu
Etude de faisabilite d'un capteur intelligent de deplacement a courants de foucault

Un capteur intelligent est un appareil dont la reponse prend en compte certaines modifications de l'environnement (grandeurs d'influence). Le travail que nous presentons consiste a essayer de montrer que l'on peut concevoir un tel appareil en prenant pour base un capteur de proximite a courants de foucault. Les grandeurs d'influence dont nous etudions les effets sont ici la temperature et l'humidite. Le conditionneur utilise est un oscillateur dont nous avons ameliore les performances de facon a atteindre une stabilite suffisante. Les acquisitions sont faites a partir d'un banc de mesure dont nous avons realise l'automatisation. Nous montrons, bien que les mesures soient perturbees par de nombreux phenomenes, qu'il est certainement possible de concevoir un capteur intelligent. Un modele theorique du capteur a ete etudie, il permet de prevoir une reponse en frequence qui est une fonction de la distance et de la temperature et montre une bonne correlation avec la realite
The Relationship between CEO-Executive Demographic Dissimilarity and Non-CEO Executive Turnover: The Chinese Case

This study investigates the association between demographic dissimilarity within CEO-executive dyads and non-CEO executive turnover. The results manifest evidently that when CEO-executive demographic dissimilarity within a CEO-executive dyad is inconsistent with social norms (e.g., the non-CEO executive is older and has longer tenure than the CEO), the non-CEO executive is more likely to exit from the top management team.
BLOOD FLOW OF THE CEREBRAL CORTEX CALCULATED FROM 85KRYPTON–BETA–CLEARANCE RECORDED OVER THE EXPOSED SURFACE; EVIDENCE OF INHOMOGENEITY OF FLOW

Injection of Krypton86 dissolved in saline into the carotid artery and counting over the exposed cortex with a Geiger-Muller tube allows to measure the local clearance rate of this isotope. This clearance rate is related to tissue blood flow according to the basic equation by Kety (1 ) as modified to apply to this special situation (2, 3, 4 ) . It is the purpose of this communication to discuss certain aspects of this method with special regard to the results hereby obtained which suggrst some degree of inhomogeneity of cortical blood flow.
Enhanced polyphosphate organism cultures in activated sludge systems-Part 1 : Enhanced culture development

In UCT and Bardenpho systems, by starting with 100 per cent municipal waste water as influent, incrementally decreasing the waste-water fraction and increasing the acetate fraction, an enhanced culture of polyphosphate (polyP) organisms was developed. Aerobic cultures, using the API procedure, indicated greater than 90 per cent of the microorganisms as Acinetobacter spp. As the acetate fraction increased, macro and micro-nutrients and yeast extract addition was necessary to maintain polyP organism growth. Of the macro-nutrients, magnesium, potassium and calcium had to be available in adequate concentrations for P uptake magnesium and potassium form the principal counter-ions for stabilising the polyP chain and, to a lesser extent, calcium; calcium was probably involved in other functions. Acid addition was necessary in the aerobic zone to maintain the pH near neutrality. At sludge ages of 10 and 20 d with 100 per cent acetate feed (500 mgCOD/l removals of about 60 and 50 mgP/l respectively were attained, P/VSS (mgP/mgVSS) of about 0,38 and VSS/TSS (mgVSS/mgTSS) of 0,46 in the aerobic zone. This enhanced culture was used to obtain information on the stoichiometry and kinetics of the growth of polyP organisms in nutrient removal systems.
The airway epithelium: more than just a structural barrier

The mammalian airway is lined by a variety of specialized epithelial cells that not only serve as a physical barrier but also respond to environment-induced damage through the release of biologically active factors and constant cellular renewal. The lung epithelium responds to environmental insults such as pathogens, cigarette smoke and pollution by secreting inflammatory mediators and antimicrobial peptides, and by recruiting immune cells to the site of infection or damage. When the epithelium is severely damaged, basal cells and Clara cells that have stem-cell-like properties are capable of self-renewal and proliferation in the affected area, to repair the damage. In order to effectively fight off infections, the epithelium requires the assistance of neutrophils recruited from the peripheral circulation through transendothelial followed by transepithelial migration events. Activated neutrophils migrate across the epithelium through a series of ligand–receptor interactions to the site of injury, where they secrete proteolytic enzymes and oxidative radicals for pathogen destruction. However, chronic activation and recruitment of neutrophils in airway diseases such as chronic obstructive pulmonary disease and asthma has been associated with tissue damage and disease severity. In this paper, we review the current understanding of the airway epithelial response to injury and its interaction with inflammatory cells, in particular the neutrophil.
Influence of heavy episodic drinking on the relation between men's locus of control and aggression toward intimate partners.

OBJECTIVE This study examined the interactive effects of locus of control and heavy episodic drinking on men's physical assault and sexual coercion against intimate partners. METHOD Participants were 151 heterosexual drinking men who completed self-report measures of locus of control, alcohol consumption during the past 12 months, and intimate-partner aggression during the past 12 months. RESULTS An internal locus of control was associated with a lower frequency of physical assault and sexual coercion toward intimate partners among men who reported lower quantities of alcohol consumption. However, data suggested that the protective qualities of an internal locus of control for both forms of partner aggression diminished among men who reported higher quantities of alcohol consumption. CONCLUSIONS These results support alcohol myopia theory and extend this theory by suggesting how alcohol consumption may affect the relation between locus of control and different forms of intimate-partner aggression toward women.
Study on Flow Characteristics of Three-Dimensional Backward-Facing Step at High Reynolds

ABSTRACT Fan, J.; Yan, C. ; Lei, P.; Wang, C. , and Liu, G. , 2020. Study on flow characteristics of three-dimensional backward-facing step at high Reynolds. In: Gong, D. ; Zhang, M. , and Liu, R. (eds.), Advances in Coastal Research: Engineering, Industry, Economy, and Sustainable Development. Journal of Coastal Research, Special Issue No. 106, pp. 522–525. Coconut Creek (Florida), ISSN 0749-0208. Based on FLUENT, the three-dimensional Realizable k-ε turbulence model is used to simulate the flow over a backward-facing step at 40 Reynolds numbers between 500 and 80,000, and the results are combined with the results of particle image velocimetry experiments to verify the reliability of the model. The three-dimensional flow characteristics of the flow over a backward-facing step at Re = 25,822 are analyzed. The results show that in the two-dimensional aspect, the numerical simulation results are in good agreement with the experimental values, the separation and reattachment zone length change curves are consistent, the flow field structure is similar, and the model reliability is high. In three dimensions, slight differences occur in the flow distribution of the sections perpendicular to Z axis, and the closer the section is to the wall, the greater the change of flow is. Along the Z axis, the velocity and turbulent energy of water flow are unevenly distributed in the spreading direction, showing strong three-dimensional flow characteristics.
AIS Electronic Library (AISeL)

The introduction of a new IT application within an organisation represents change, and the acceptance of such change starts with the individual end users since they are the ones that often resist the newly introduced IT. This research identifies the factors that affect the acceptance of new technologies in the workplace in order to understand better how end-users can influence the successful introduction of IT in academic institutions. We use one Higher Education Institution (HEI) in Hong Kong and one HEI in the UK in order to gather our data and cross analyse the differences between the two countries. Our research shows that the staff at both universities have a high Behavioral Intention (BI) to use new technologies. However, there is no significant difference between the two universities, which means that although there is a general difference in the Hofstede’s cultural dimension scores between the two populations, these dimensions have no effect on the staff who works at these universities.
Flexible Temperature Sensor Array using Electro-Resistive Polymer Forhumanoid Artificial Skin

This paper presents a novel method to fabricate temperature sensor arrays by dispensing electro-resistive polymer on flexible polyimide films. The sensor array can be used as humanoid artificial skin for sensation system of robots. Polydimethlysiloxane (PDMS) was used as the matrix of the electro- resistive composites and different conductive fillers such as carbon black, graphite powder, carbon nano- fibrils have been investigated. It was found that graphite powder serves as the best conductive filler for highest temperature sensitivity and better stability. The volume fraction of the graphite powder for large dynamic range from 20degC to 100degC has been investigated and was found to be 20%. The detected temperature contours are in well agreement with the shapes and magnitudes of different heat sources.
Discriminant Analysis Between Myocardial Infarction Patients and Healthy Subjects Using Wavelet Transformed Signal Averaged Electrocardiogram and Probabilistic Neural Network

There are a variety of electrocardiogram based methods to detect myocardial infarction (MI) patients. This study used the signal averaged electrocardiogram (SAECG) and its wavelet coefficient as an index to detect MI. Orthogonal leads signals from 50 acute myocardial infarction (AMI) and 50 healthy subjects were selected from the national metrology institute of Germany (PTB diagnostic database). They were filtered and discrete wavelet transformed was exerted on them. Four conventional features and two new features introduced in this study were extracted from SAECG and its wavelet decompositions. Finally for data classification, probabilistic neural network were used. This method was able to detect and discriminate AMI patients from healthy subjects using the probabilistic neural network, which shows 93.0% sensitivity at 86.0% specificity with 89.5% accuracy. This technique and the new extracted features showed good promise in the identification of MI patients. However, the sensitivity and specificity is comparable with other findings and has high accuracy although we extracted only 6 features.