Miracle-dz/UniFAR-FTUs huggingface dataset:
Sleep apnea in patients with myasthenia gravis

To assess the prevalence of obstructive sleep apnea (OSA) in myasthenia gravis, the authors identified patients at risk of OSA using the multivariable apnea prediction index. OSA was diagnosed with polysomnography. The prevalence of OSA was 36% compared to an expected prevalence of 15 to 20% in the general population. When including the presence of daytime sleepiness (OSA syndrome), the prevalence was 11% compared to 3% in the general population.
[A new shortened version of the Boston Naming Test for those aged over 65: an approach from item response theory].

INTRODUCTION One of the tests that is mostly widely used to evaluate aphasia in clinical practice is the Boston Naming Test (BNT), a classic test in which 60 black and white pictures are presented to subjects in order to evaluate their capacity to put a name to such pictures. Despite its psychometric goodness, the number of items in the test has to be reduced in order to lower the time required to apply it. SUBJECTS AND METHODS Researchers recruited a sample of 547 subjects over the age of 65, who were then administered a neuropsychological evaluation protocol, including the BNT, to determine their cognitive statuses. No relevant cognitive alterations were observed in 405 subjects versus 142 who were diagnosed with mild cognitive impairment. RESULTS The number of items was reduced in accordance with the premises of the item response theory. Since both age and level of schooling were found to have a significant effect on performance in the test, the two variables were used to find the cut-off points of the shortened version. This new version presented an adequate degree of reliability (alpha = 0.765) and a high correlation with the original test (r = 0.876). CONCLUSIONS The new shortened version consists of 15 items that are ordered according to the degree of difficulty. It is a task with a high level of discriminating power that is useful in day-to-day clinical practice for detecting alterations in the language of the elderly.
The Family-Home Nutrition Environment and Dietary Intake in Rural Children

Obesity and food insecurity rates are higher among rural compared to non-rural populations. Little is known, however, about how family-home environments influence childhood obesity-related behaviors, particularly in rural settings. This study examined associations between the family-home nutrition (FN) environment, food insecurity, and dietary intake (fruits, vegetables, whole grains, dairy, protein foods, and added sugars) in rural elementary school-age children (grades K-5/6; n = 102). Parents/caregivers completed surveys on FN, food insecurity, and the Block Kids Food Screener (BKFS). Body mass index (BMI, kg/m2) was calculated from measured height and weight. Approximately 33% of children were classified as overweight/obese and 28% of families were at-risk for food insecurity. Multivariable linear regression analyses examined associations between dietary intakes with FN and food insecurity. More favorable FN scores were associated with lower added sugar intake (B = −1.38, p = 0.04) and higher vegetable (B = 0.15, p < 0.001), fruit (B = 0.71, p = 0.01), and dairy (B = 0.31, p < 0.001) intakes. No significant associations were found between food insecurity and dietary intake. Given the association between higher FN scores and more favorable dietary intake, promoting healthy FN environments among rural children is warranted.
MicroRNA-125a-3p expression in abdominal adipose tissues is associated with insulin signalling gene expressions in morbid obesity: observations in Taiwanese.

BACKGROUND Micro (mi) RNAs have been found to play an important role in the regulation of adipogenesis and insulin sensitivity. However, associations between miRNA and insulin signalling-related gene expressions in abdominal adipose tissues in obese subjects remain unclear. METHODS We used a microarray platform to screen miRNA expressions in abdominal adipose tissues between genders in severely obese subjects and found that the top-ranking miRNA in abdominal omental adipose tissues was miRNA-125a-3p. MicroR-125a-3p and insulin signalling-related gene expressions in abdominal omental adipose tissues of all subjects (11 men and 10 women) were subsequently quantified by a real-time PCR. Also, associations of miR-125a-3p with insulin signalling-related gene expression and biochemical markers in obese subjects were analyzed by a linear regression analysis. RESULTS miR-125a-3p expressed by abdominal omental adipose tissues was much higher in obese men than women. No gender difference was observed in abdominal subcutaneous adipose tissues. Concomitant with high miR-125a-3p, c-Jun N-terminal kinase gene expression was also higher, whereas insulin receptor was lower in men than women. There were negative associations of miR-125a-3p with the insulin receptor and phosphatidylinositol 3-kinase expressions. Fasting plasma glucose and cholesterol levels were positively associated with miR- 125a-3p expression. These associations were obvious in obese men but not women. CONCLUSION Our results support the involvement of miR-125a-3p in regulating the insulin signalling pathway and imply that increased miR- 125a-3p expression in omental adipose tissues may be a characteristic feature of insulin resistance in obese men.
National Growth Charts for the United Arab Emirates

Background Information on the health and growth status of the population is essential for planning and administering health promotion programs. Methods This is a cross-sectional study of the anthropometric measurements of United Arab Emirates (UAE) children aged 0-18 years, by a multistage stratified random sampling technique based on age and sex. Healthy, full-term children of UAE nationality who did not have any diseases that could affect their growth pattern were included in the study. Children were selected using multistage sampling, using sampling proportional to size methods in 9 geographical areas. Growth charts for various anthropometric measures were created using Cole’s LMS statistical package. This package estimates age-specific percentiles with the use of smoothing splines after transformation to normality. Results A total of 21,068 children (12,159 females) between the ages of 0 and 18 years were studied. In the present study, we included 8-15% of the population aged 0-18 years. The growth chart for 0-36 months is very similar to the NCHS growth reference chart in terms of both weight for age and length and height for age. The mean (+SD) length/height in children was 49.9 ± 3.2 cm at birth, 75.9 ± 5.7 cm at 12 months, 86.4 ± 4.5 cm at 24 months, 95.1 ± 5.9 cm at 36 months, and 111.1 ± 6.4 cm at 60 months. The height of UAE children in the first 3 years of life, especially at the ages of 2 and 3 years, mirrored those achieved by Brazilian children in the WHO study. Conclusion The results of the present study are useful for growth assessment of UAE children.
Image-based computational simulation of flow dynamics in a giant intracranial aneurysm.

BACKGROUND AND PURPOSE Blood flow dynamics are thought to play an important role in the pathogenesis and treatment of intracranial aneurysms; however, hemodynamic quantities of interest are difficult to measure in vivo. This study shows that computational fluid dynamics (CFD) combined with computed rotational angiography can provide such hemodynamic information in a patient-specific and prospective manner. METHODS A 58-year-old woman presented with partial right IIIrd cranial nerve palsy due to a giant carotid-posterior communicating artery aneurysm that was subsequently coiled. Computed rotational angiography provided high resolution volumetric image data from which the lumen geometry was extracted. This and a representative flow rate waveform were provided as boundary conditions for finite element CFD simulation of the 3D pulsatile velocity field. RESULTS CFD analysis revealed high speed flow entering the aneurysm at the proximal and distal ends of the neck, promoting the formation of both persistent and transient vortices within the aneurysm sac. This produced dynamic patterns of elevated and oscillatory wall shear stresses distal to the neck and along the sidewalls of the aneurysm. These hemodynamic features were consistent with patterns of contrast agent wash-in during cine angiography and with the configuration of coil compaction observed at 6-month follow-up. CONCLUSION Anatomic realism of lumen geometry and flow pulsatility is essential for elucidating the patient-specific nature of aneurysm hemodynamics. Such image-based CFD analysis may be used to provide key hemodynamic information for prospective studies of aneurysm growth and rupture or to predict the response of an individual aneurysm to therapeutic options.
Binge Drinking & Sex in High School

This paper estimates the impact of binge drinking on sexual activity among a nationally representative set of high school students during the 1990s and 2000s. The main innovations are explicitly controlling for time-invariant preferences regarding sexual behavior and alcohol use, and eliminating non-drinkers from the comparison group. I find that binge drinking significantly increases participation in sex, promiscuity, and the failure to use birth control, albeit by amounts considerably smaller than implied by merely conditioning on exogenous factors. For all outcomes, impacts rise substantially with binge drinking frequency. Results are similar using alternative comparison groups defined by excluding those who do not exhibit other risky behaviors, and by gender and race/ethnicity, but vary by grade level and over time in different ways for engaging in sex than protective behavior. Effects are much larger for the small fraction of students that has not been taught about AIDS/HIV infection in school.
A Systematic Analysis of Predicted Phosphorylation Sites within the Human Pregnane X Receptor Protein

The pregnane X receptor (PXR, NR1I2) regulates the expression of genes that encode drug-metabolizing enzymes and drug transporter proteins in liver and intestine. Understanding the molecular mechanisms that modulate PXR activity is therefore critical for the development of effective therapeutic strategies. Several recent studies have implicated the activation of kinase signaling pathways in the regulation of PXR biological activity, although direct evidence and molecular mechanisms are currently lacking. We therefore sought to characterize potential phosphorylation sites within the PXR protein by use of a rational, comprehensive, and systematic site-directed mutagenesis approach to generate phosphomimetic mutations (Ser/Thr → Asp) and phospho-deficient mutations (Ser/Thr → Ala) at 18 predicted consensus kinase recognition sequences in the human PXR protein. Here, we identify amino acid residues Ser8, Thr57, Ser208, Ser305, Ser350, and Thr408 as being critical for biological activity of the PXR protein. Mutations at positions 57 and 408 abolish ligand-inducible PXR activity. Mutations in the extreme N terminus and in the PXR ligand-binding domain at positions Ser8, Ser305, Ser350, and Thr408 decrease the ability of PXR to form heterodimers with retinoid X receptor α. Mutations at positions Ser208, Ser305, Ser350, and Thr408 alter PXR-protein cofactor interactions. Finally, the subcellular localization of the PXR protein is profoundly affected by mutations at position Thr408. These data suggest that PXR activity can potentially be regulated by phosphorylation at specific amino acid residues within several predicted consensus kinase recognition sequences to differentially affect PXR biological activity.
Dynamic Texture Segmentation Using Fourier Transform

Dynamic textures are temporally continuous and infinitely varying sequences of images with certain spatial and temporal stationarity properties and have many potential applications such as computer graphics, computer vision, animation, and computer games. These applications usually require dynamic texture segmentation that is not an easy task especially when the background is cluttered and textured. In this paper, we analyze the spatio-temporal slices of dynamic texture using Fourier analysis and then we propose a simple and efficient approach to dynamic texture segmentation using 3D Fourier transform. Experiments on several dynamic texture sequences show the effectiveness of the proposed approach.
Integrative modeling of the cardiac ventricular myocyte

Cardiac electrophysiology is a discipline with a rich 50‐year history of experimental research coupled with integrative modeling which has enabled us to achieve a quantitative understanding of the relationships between molecular function and the integrated behavior of the cardiac myocyte in health and disease. In this paper, we review the development of integrative computational models of the cardiac myocyte. We begin with a historical overview of key cardiac cell models that helped shape the field. We then narrow our focus to models of the cardiac ventricular myocyte and describe these models in the context of their subcellular functional systems including dynamic models of voltage‐gated ion channels, mitochondrial energy production, ATP‐dependent and electrogenic membrane transporters, intracellular Ca dynamics, mechanical contraction, and regulatory signal transduction pathways. We describe key advances and limitations of the models as well as point to new directions for future modeling research. WIREs Syst Biol Med 2011 3 392–413 DOI: 10.1002/wsbm.122
Exploring the adoption of interactive digital television services as a retail shopping platform

The aim of this research is to consider the possible effect of an emerging technology platform on the uptake of online shopping: interactive (digital) Television (iTV), which enables viewers to select a variety of viewing options, publicity materials, games, entertainment and more recently shopping. An augmented version of the original TAM is applied to this study. Two new constructs are considered namely access and awareness together with perceived ease of use, perceived usefulness, perceived enjoyment and security. The results show that indeed the augmented TAM can be used as a predictive model for the adoption of iTV as an online shopping platform. It is concluded that access, perceived ease of use, perceived enjoyment and perceived usefulness are significant factors to determine the consumers’behavioural intentions towards the use of digital TV as a new shopping platform. However, awareness and security are considered to be insignificant with no effect on consumers’ behavioural intentions towards the new shopping medium.
Adolescent diversity in ethnic, economic, and cultural contexts

Paths to Adulthood - R Montemayor Adolescent Diversity in Contemporary America Competence among Urban Adolescents in Poverty - H Yoshikawa and E Seidman Multiple Forms, Contexts and Developmental Processes Rural Youth - L Crockett, M Shanahan and J Jackson-Newsom Ecological and Life Course Perspectives Growing Up in Appalachia - S Wilson and G Peterson Ecological Influences on Adolescent Development Indian Adolescence - F Beauvais Opportunity and Challenge Healthy Adjustment in Mexican American and Other Hispanic Adolescents - F Castro, G Boyer and H Balcazar Asian American Adolescents - F Leong, R Chato and E Hardin A Research Review to Dispel the Model Minority Myth Ecological Correlates of the Social and Emotional Adjustment of African American Adolescents - R Taylor, L Jacobsen and D Roberts Conceptual and Methodological Issues in Studying Minority Adolescents - M Cunningham and M Beale Spencer The Variety of Adolescent Experiences - R Montemayor
Evolutionary Origins of Lymphocytes: Ensembles of T Cell and B Cell Transcriptional Regulators in a Cartilaginous Fish1

The evolutionary origins of lymphocytes can be traced by phylogenetic comparisons of key features. Homologs of rearranging TCR and Ig (B cell receptor) genes are present in jawed vertebrates, but have not been identified in other animal groups. In contrast, most of the transcription factors that are essential for the development of mammalian T and B lymphocytes belong to multigene families that are represented by members in the majority of the metazoans, providing a potential bridge to prevertebrate ancestral roles. This work investigates the structure and regulation of homologs of specific transcription factors known to regulate mammalian T and B cell development in a representative of the earliest diverging jawed vertebrates, the clearnose skate (Raja eglanteria). Skate orthologs of mammalian GATA-3, GATA-1, EBF-1, Pax-5, Pax-6, Runx2, and Runx3 have been characterized. GATA-3, Pax-5, Runx3, EBF-1, Spi-C, and most members of the Ikaros family are shown throughout ontogeny to be 1) coregulated with TCR or Ig expression, and 2) coexpressed with each other in combinations that for the most part correspond to known mouse T and B cell patterns, supporting conservation of function. These results indicate that multiple components of the gene regulatory networks that operate in mammalian T cell and B cell development were present in the common ancestor of the mammals and the cartilaginous fish. However, certain factors relevant to the B lineage differ in their tissue-specific expression patterns from their mouse counterparts, suggesting expanded or divergent B lineage characteristics or tissue specificity in these animals.
Galahad: a web server for drug effect analysis from gene expression

Galahad (https://galahad.esat.kuleuven.be) is a web-based application for analysis of drug effects. It provides an intuitive interface to be used by anybody interested in leveraging microarray data to gain insights into the pharmacological effects of a drug, mainly identification of candidate targets, elucidation of mode of action and understanding of off-target effects. The core of Galahad is a network-based analysis method of gene expression. As an input, Galahad takes raw Affymetrix human microarray data from treatment versus control experiments and provides quality control and data exploration tools, as well as computation of differential expression. Alternatively, differential expression values can be uploaded directly. Using these differential expression values, drug target prioritization and both pathway and disease enrichment can be calculated and visualized. Drug target prioritization is based on the integration of the gene expression data with a functional protein association network. The web site is free and open to all and there is no login requirement.
The Milgram experiment: Its impact and interpretation

Milgrams' experiment which investigated obedience to authority is one of the most well-known psychological studies of all time. The study is widely considered ethically controversial, and found its results striking and disturbing. This raises the question as to which part of the study contributed the most to the way it was interpreted by the scientific community. Milgrams' study had a harmful effect on his participants and is considered to have included unethical aspects. The experiment showed that 65% of the experimental subjects obeyed authority until the end of the experiment and carried out orders that they believed involved extreme harm to others. After the experiment, ethical guidelines developed which require valid informed consent and a proper consideration of the possible harm which might be inflicted upon experimental subjects. There is an ongoing debate regarding the extent to which ethical guidelines might hinder relevant research. The Milgram experiment probably initially attracted the attention it did because of its results. It was only after the results were widely reported that, the methods of the experiment were considered and the study became known as ethically controversial.
A Web-Based Framework to Design and Deploy Mobile Learning Activities: Evaluating Its usability, Learnability and Acceptance

This paper discusses the efforts carried out related to the design and development of a web-based framework that allows designing, deploying and executing mobile data collecting applications. Furthermore, it also allows analyzing and presenting the data that is generated during the mentioned process. The fact that the framework is completely web-based provides a platform independent execution of the mobile application on any mobile device with a web-browser. As a result that the whole life-cycle of creating, executing and discussing a mobile learning activity is implemented in pure web-based manner separates this work from similar efforts. In the course of this work, the current state of development of two of the components, the authoring tool and the mobile application is presented. This framework was introduced to teachers in an activity to follow up an initial study. On the basis of a workshop with teachers, we performed an explorative study regarding the technology acceptance and usability of two components of the proposed framework. The results are discussed and analyzed in this paper.
Does body mass index influence functional capacity in prepubescent children

The proportion of overweight or obese children is steadily increasing. Despite this fact, virtually no research has been conducted to examine whether the functional capacity of these children is adversely affected by excess weight. The purpose of the present study was, therefore, to assess selected physical characteristics and functional capacities of prepubescent children to determine possible functional limitations experienced by obese children. Four hundred and thirty one (boys = 212, girls = 219) Grade 3 students (mean age = 8.5 + 0.5 years) from 18 randomly selected primary schools in the Wollongong District participated as subjects for this study. Subjects were required to progress through a circuit of stations designed to assess selected physical characteristics and functional capacities. Physical measures included height, body mass, lower limb alignment, and footprint structure. Functional tasks included a sit and reach test, upper limb static strength, a basketball throw, sit-to-stand transfers, a vertical jump and a standing long jump. Body mass index (BMI) scores for all subjects were calculated and correlated to the performance scores on each of the functional tasks to establish the relationship between obesity and functional capacity. Data for 43 Obese subjects (BMI > 95th percentile for age and gender) and 43 Non-obese subjects (BMI at the 50th percentile for age and gender) were also compared to identify any significant differences (p < 0.05) between the obese and non­ obese children with respect to the physical characteristics or functional capacity data. Pearson Product moment correlations indicated that as BMI increased, flexibility, sit-to-stand transfer ability, vertical jump and standing long jump
SparsityBoost: A New Scoring Function for Learning Bayesian Network Structure

We give a new consistent scoring function for structure learning of Bayesian networks. In contrast to traditional approaches to scorebased structure learning, such as BDeu or MDL, the complexity penalty that we propose is data-dependent and is given by the probability that a conditional independence test correctly shows that an edge cannot exist. What really distinguishes this new scoring function from earlier work is that it has the property of becoming computationally easier to maximize as the amount of data increases. We prove a polynomial sample complexity result, showing that maximizing this score is guaranteed to correctly learn a structure with no false edges and a distribution close to the generating distribution, whenever there exists a Bayesian network which is a perfect map for the data generating distribution. Although the new score can be used with any search algorithm, we give empirical results showing that it is particularly effective when used together with a linear programming relaxation approach to Bayesian network structure learning.