Miracle-dz/UniFAR-FTUs huggingface dataset:
Dose-response relationship of levodopa with mood and anxiety in fluctuating Parkinson's disease

We investigated the effect of levodopa on mood and anxiety in eight Parkinson's disease patients with motor fluctuations.Each patient received 0.0-, 0.5-, and 1.0-mg/kg/hr levodopa infusions in randomly assigned order under double-blind conditions on consecutive days. Mood elevation and anxiety reduction based on half-hourly patient rating and a corresponding increase in tapping speed occurred with active drug infusion but not placebo infusion. The effects were dose related. The higher-dose infusion rate produced more rapid onset, greater magnitude, and longer duration of response. We conclude that mood and anxiety fluctuations related to levodopa dosing are robust pharmacologic, and not placebo, effects. NEUROLOGY 1995;45: 1757-1760
Current injection solutions for active suspension in bearingless motors

Traditionally, active magnetic levitation systems in rotor applications comprise separate motor for torque production, two or more radial active magnetic bearings (AMBs) and one axial AMB. Such an arrangement produces long rotors. Resulting AMB-rotor systems are often supercritical making the levitation control challenging. The centralization of the torque and force producing actuators shortens the rotor and allows for better control of unbalance magnetic pull from the rotor eccentricity. However, traditional bearingless motors employ separate windings for torque and for force production using a single actuator. This in turn lengthens the motor flux paths, increases the stator diameters, and reduces efficiency. This work studies performance and limitations of three current injection methods applied for active levitation control where the same winding is used for torque and for levitation force production. The FEM time stepping simulation results are presented and quantitative comparison is given. The case study bearingless motor system is of considerable power and high speed ratings. The use of the single winding system with the current injection control is suitable for the high-power and high-speed bearingless motor applications.
Compact High-Precision Models for Silicon p-n Step Junction Avalanche-Breakdown Voltages

Advanced silicon impact-ionization models are linked with simple accurate 1-D breakdown-voltage formulas for p-n step junctions. The models are useful for ab initio calculations and improve the accuracy of older models due to a new parameterization based on a numerical simulation. New parameters for effective impact-ionization coefficients are presented for Chynoweth and Fulop formulations. The parameter sets are based on impact-ionization models of Van Overstraeten and De Man and of the Universita di Bologna, including its recent updates. They allow quick computing of silicon p-n junction breakdown voltages from 10 V to 10 kV with maximum deviation from numerical data of ±5%. The new breakdown-voltage models account for the junction temperature and the depletion on both sides of the p-n junction.
Immunochemical analysis of inner and outer membranes of Escherichia coli by crossed immunoelectrophoresis

Isolated membrane fractions of Escherichia coli K-12 yielded complex immunoprecipitate patterns when Triton X-100 and sodium dodecyl sulfate extracts were examined by crossed immunoelectrophoresis with antienvelope immunoglobulins. Twelve of the 46 antigens in the immunoprecipitate patterns of inner (plasma) membranes were identified by zymograms and/or by the use of specific antisera. The following enzyme activities were detected in immunoprecipitates: 6-phosphogluconate dehydrogenase (EC 1.1.1.43); adenosine triphosphatase (EC 3.6.1.3); glutamate dehydrogenase (EC 1.4.1.4), two separate components; malate dehydrogenase (EC 1.1.1.37); dihydroorotate dehydrogenase (EC 1.3.3.1); succinate dehydrogenase (EC 1.3.99.1); lactate dehydrogeanse (EC 1.1.1.27); reduced nicotinamide adenine dinucleotide dehydrogenase (EC 1.6.99.3); protease (EC 3.4.21.1); and glycerol 3-phosphate dehydrogenase (EC 1.1.99.5). The corresponding immunoprecipitate pattern for isolated outer membranes consisted of at least 25 discrete antigens and differed strikingly from that obtained with inner membranes. Two major immunogens were identified as lipopolysaccharide and Braun lipoprotein. A protease-active immunoprecipitate was also detected in this fraction, but attempts to identify the Rosenbusch matrix protein in the crossed immunoelectrophoretic profile were unsuccessful.
Holonomies and the slope inequality of Lefschetz fibrations

In this paper, we consider two necessary conditions: the irreducibility of the holonomy group and the slope inequality for which a Lefschetz fibration over a closed orientable surface is a holomorphic fibration. We show that these two conditions are independent in the sense that neither one implies the other.
Expression of Placental Leucine Aminopeptidase Is Associated with a Poor Outcome in Endometrial Endometrioid Adenocarcinoma

Objective: Placental leucine aminopeptidase (P-LAP) is a cell surface aminopeptidase (oxytocinase). We cloned P-LAP cDNA and found a widespread tissue distribution of P-LAP. Since P-LAP can degrade several small peptide hormones such as oxytocin, this enzyme may affect many cellular functions of carcinoma cells as well as normal cells. This study investigated whether the expression of P-LAP correlates with clinicopathologic factors and prognosis in patients with endometrial endometrioid adenocarcinoma. Methods: Histologic sections of formalin-fixed, paraffin-embedded specimens from 99 primary endometrial carcinomas were stained for P-LAP using polyclonal P-LAP antibody. Disease-free survival and other clinicopathologic characteristics were analyzed according to the intensity of P-LAP staining. Results: Of 99 cases, 69 (69.7%) showed specific P-LAP immunostaining. We found a positive correlation between the expression of P-LAP and histological grade (p < 0.01), surgical stage of the disease (p = 0.02), myometrial invasion (p = 0.01), lymph node involvement (p < 0.01), and vascular infiltration (p < 0.01). In patients who had strongly positive P-LAP staining, the disease-free interval was significantly lower than in patients who had negative or weakly positive P-LAP staining (p < 0.01). Multivariate analysis demonstrated that strongly immunoreactive P-LAP (odds ratio, 12.8; 95% confidence interval, 2.84–58.8; p < 0.01) and surgical stage (odds ratio, 8.78; 95% confidence interval, 2.77–27.8; p < 0.01) are independent prognostic factors. Conclusions: This study suggests P-LAP as an independent prognosticator of clinical outcome in patients with endometrial carcinoma. Therefore, assessment of the P-LAP status provides clinically useful prognostic information in patients with endometrial carcinoma.
Human IgE Synthesis in vitro

Using monoclonal anti‐human IgE antibodies recognizing the Dɛ1 or Dɛ2 epitope, we have developed a sandwich radioimmunoassay (RIA) to determine IgE in human cell cultures. With the help of this assay, various methods of measuring an actual de novo IgE synthesis were compared. It was necessary to substract preformed IgE from released IgE in the culture supernatant and the IgE associated to the cultured cells, in order to determine a net IgE synthesis which would reflect de novo synthesized IgE. Using this differential in vitro IgE assessment, no net IgE synthesis could be demonstrated in culture conditions which lead to strong IgG synthesis. Actual net in vitro IgE antibody production was only found in approximatively 30% of cell cultures from atopic donors. This spontaneous IgE synthesis did not correlate to the serum IgE levels of the patients. However, correlations were found between serum IgE levels and amount of preformed, released or cell‐associated IgE of the cultures.
Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG‐positive prostate cancer

Gene fusions between prostate‐specific, androgen responsive TMPRSS2 gene and oncogenic ETS factors, such as ERG, occur in up to 50% of all prostate cancers. We recently defined a gene signature that was characteristic to prostate cancers with ERG activation. This suggested epigenetic reprogramming, such as upregulation of histone deactylase 1 (HDAC1) gene and downregulation of its target genes. We then hypothesized that patients with ERG‐positive prostate cancers may benefit from epigenetic therapy such as HDAC inhibition (HDACi), especially in combination with antiandrogens. Here, we exposed ERG‐positive prostate cancer cell lines to HDAC inhibitors Trichostatin A (TSA), MS‐275 and suberoylanilide hydroxamic acid (SAHA) with or without androgen deprivation. We explored the effects on cell phenotype, gene expression as well as ERG and androgen receptor (AR) signaling. When compared with 5 other prostate cell lines, ERG‐positive VCaP and DuCap cells were extremely sensitive to HDACi, in particular TSA, showing synergy with concomitant androgen deprivation increasing apoptosis. Both of the HDAC inhibitors studied caused repression of the ERG‐fusion gene, whereas the pan‐HDAC inhibitor TSA prominently repressed the ERG‐associated gene signature. Additionally, HDACi and flutamide caused retention of AR in the cytoplasm, indicating blockage of androgen signaling. Our results support the hypothesis that HDACi, especially in combination with androgen deprivation, is effective against TMPRSS2‐ERG‐fusion positive prostate cancer in vitro. Together with our previous in vivo observations of an “epigenetic reprogramming gene signature” in clinical ERG‐positive prostate cancers, these studies provide mechanistic insights to ERG‐associated tumorigenesis and suggest therapeutic paradigms to be tested in vivo. © 2008 Wiley‐Liss, Inc.
Prevalence of comorbidities and evaluation of their screening in spondyloarthritis: results of the international cross-sectional ASAS-COMOSPA study

Background Increased risk of some comorbidities has been reported in spondyloarthritis (SpA). Recommendations for detection/management of some of these comorbidities have been proposed, and it is known that a gap exists between these and their implementation in practice. Objective To evaluate (1) the prevalence of comorbidities and risk factors in different countries worldwide, (2) the gap between available recommendations and daily practice for management of these comorbidities and (3) the prevalence of previously unknown risk factors detected as a result of the present initiative. Methods Cross-sectional international study with 22 participating countries (from four continents), including 3984 patients with SpA according to the rheumatologist. Statistical analysis The prevalence of comorbidities (cardiovascular, infection, cancer, osteoporosis and gastrointestinal) and risk factors; percentage of patients optimally monitored for comorbidities according to available recommendations and percentage of patients for whom a risk factor was detected due to this study. Results The most frequent comorbidities were osteoporosis (13%) and gastroduodenal ulcer (11%). The most frequent risk factors were hypertension (34%), smoking (29%) and hypercholesterolaemia (27%). Substantial intercountry variability was observed for screening of comorbidities (eg, for LDL cholesterol measurement: from 8% (Taiwan) to 98% (Germany)). Systematic evaluation (eg, blood pressure (BP), cholesterol) during this study unveiled previously unknown risk factors (eg, elevated BP (14%)), emphasising the suboptimal monitoring of comorbidities. Conclusions A high prevalence of comorbidities in SpA has been shown. Rigorous application of systematic evaluation of comorbidities may permit earlier detection, which may ultimately result in an improved outcome of patients with SpA.
Japanese versions of the Executive Interview (J-EXIT25) and the Executive Clock Drawing Task (J-CLOX) for older people

ABSTRACT Background: The aim of the study was to develop the Japanese versions of Executive Interview (J-EXIT25) and Executive Clock Drawing Task (J-CLOX) and to evaluate the aspects of executive function that these two tests will be examining. Methods: The concurrent validity and reliability of J-EXIT25 and J-CLOX were first examined in all participants (n = 201). Next, the relationship between the two tests was examined using receiver operating characteristic (ROC), correlation, and regression analyses in healthy participants (n = 45) and participants with mild cognitive impairment (n = 36) and dementia (n = 95). Results: Satisfactory concurrent validity and reliability of J-EXIT25 and J-CLOX were shown. ROC analysis indicated that J-EXIT25 and J-CLOX1 were superior to the Frontal Assessment Battery, but inferior to the Mini-Mental State Examination (MMSE), in discriminating between non-dementia and dementia. J-EXIT25, J-CLOX1, and J-CLOX2 scores were significantly correlated with age, scores on the MMSE, Instrumental Activities of Daily Living (IADL) and Physical Self-Maintenance Scale (PSMS), and care level. In stepwise regression analyses of IADL scores, MMSE and J-EXIT25 were significantly independent predictors in men, and MMSE, age, and J-CLOX1 were significantly independent predictors in women. J-EXIT25, MMSE, and J-CLOX1 were significantly independent predictors in stepwise regression analysis of PSMS scores, and J-EXIT25 was the only significantly independent predictor in stepwise regression analysis of care level. Conclusions: J-EXIT25 and J-CLOX are valid and reliable instruments for assessment of executive function in older people. The present results suggest that these tests have common and distinct psychometric properties in the assessment of executive function.
Estimativa de Permeabilidade Absoluta com Processamento de Imagens Utilizando Distribuição de Tamanho de Grãos

A determinacao da permeabilidade e fundamental na caracterizacao de meios porosos em especial para estimar a capacidade de armazenamento e escoamento em formacoes particuladas. Diversos modelos baseados em tamanhos de graos foram propostos para quantificar a permeabilidade. Todavia tais modelos a\-pre\-sen\-tam limitacoes significativas que tornam seu uso restrito em diversas aplicacoes praticas. Neste trabalho apresentamos dois modelos, o primeiro, baseado no trabalho de Panda e Lake e o segundo, no trabalho de Kozeny e Carman, discutindo suas potenciais aplicacoes em imagens digitais de rochas geologicas e limitacoes com relacao a forma de medicao de alguns parâmetros. Para analisar o desempenho destes modelos realizamos testes com imagens de microtomografia de amostras confeccionada com microesferas, buscando simular imagens de solo. As amostras sinteticas permitem construir um ambiente controlado para comparacao com medidas obtidas apos a analise digital. Propomos uma cadeia de processamento de imagens para estimar medidas de permeabilidade e comparamos com quantidades obtidas atraves de simulacoes de fluxo. Verificamos que o modelo analitico Kozeny-Carman Generalizado obtivemos uma estimativa de permeabilidade absoluta em uma distribuicao de particulas sinteticas com uma precisao de $\pm 0.4 \mu m^2$ e $\pm 61.1 \mu m^2$ (em duas amostras distintas). Com taxa de exatidao de $98 \%$ e $99 \%$ respectivamente, quando comparados com os valores obtidos atraves das simulacoes de fluxo.
Using trigger phrases to detect adverse drug reactions in ambulatory care notes

Background: As medical care moves towards an outpatient focus, monitoring systems for ambulatory patients are increasingly important. Because adverse outcomes due to medications are an important problem in outpatients, the authors developed an automated monitoring system for detecting adverse drug reactions (ADRs) in ambulatory patients. Methods: The authors obtained a set of approximately 110 000 ambulatory care notes from the medicine clinic at Bellevue Hospital Centre for 2003–4, and manually analysed a representative sample of 1250 notes to obtain a gold standard. To detect ADRs in the text of electronic ambulatory notes, the authors used a “trigger phrases” methodology, based on a simple grammar populated with a limited set of keywords. Results: Under current functionality, this system detected 38 of 54 cases in the authors’ gold standard set, of which 17 were true positives, for a sensitivity of 31%, a specificity of 98%, and a positive predictive value of 45%. Their proxy measure correlated with 70% of the ADRs in the gold standard. These values are comparable or superior to other systems described in the literature. Conclusions: These results show that an automated system can detect ADRs with moderate sensitivity and high specificity, and has the potential to serve as the basis for a larger scale reporting system.
Placenta Growth Factor and Vascular Endothelial Growth Factor A Have Differential, Cell‐Type Specific Patterns of Expression in Vascular Cells

PLGF, a VEGF‐A related protein, mediates collateral enlargement via monocytes but plays little role in capillary proliferation. In contrast, VEGF‐A mediates both collateral enlargement and capillary proliferation. PLGF has been less thoroughly studied than VEGF‐A, and questions remain regarding its regulation and function. Therefore, our goal was to characterize the expression of PLGF by vascular cells. We hypothesized that vascular SMC would express more PLGF than EC, since VEGF‐A is primarily expressed by non‐EC.
Genotype score in addition to common risk factors for prediction of type 2 diabetes.

BACKGROUND Multiple genetic loci have been convincingly associated with the risk of type 2 diabetes mellitus. We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors alone. METHODS We genotyped single-nucleotide polymorphisms (SNPs) at 18 loci associated with diabetes in 2377 participants of the Framingham Offspring Study. We created a genotype score from the number of risk alleles and used logistic regression to generate C statistics indicating the extent to which the genotype score can discriminate the risk of diabetes when used alone and in addition to clinical risk factors. RESULTS There were 255 new cases of diabetes during 28 years of follow-up. The mean (+/-SD) genotype score was 17.7+/-2.7 among subjects in whom diabetes developed and 17.1+/-2.6 among those in whom diabetes did not develop (P<0.001). The sex-adjusted odds ratio for diabetes was 1.12 per risk allele (95% confidence interval, 1.07 to 1.17). The C statistic was 0.534 without the genotype score and 0.581 with the score (P=0.01). In a model adjusted for sex and self-reported family history of diabetes, the C statistic was 0.595 without the genotype score and 0.615 with the score (P=0.11). In a model adjusted for age, sex, family history, body-mass index, fasting glucose level, systolic blood pressure, high-density lipoprotein cholesterol level, and triglyceride level, the C statistic was 0.900 without the genotype score and 0.901 with the score (P=0.49). The genotype score resulted in the appropriate risk reclassification of, at most, 4% of the subjects. CONCLUSIONS A genotype score based on 18 risk alleles predicted new cases of diabetes in the community but provided only a slightly better prediction of risk than knowledge of common risk factors alone.
Integral Higher Order Sliding Mode and singular optimal stabilization

This paper explores the possibilities of the so-called Integral Higher-Order Sliding-Mode (IHOSM) control framework to solve singular optimal stabilization (SOS) problems of arbitrary order for uncertain systems. We connect the order of singularity of SOS with the co-dimension of the set of singular optimal manifold. IHOSM is designed allowing to reach singular optimal manifold in prescribing time moment and ensures SOS. Moreover, this controller provides the insensitivity of trajectory w.r. t. matched bounded uncertainties.
On a class of unimodal distributions

A distribution function F(x) is said to be unimodal [1, p. 157] if there exists at least one value x = a such that F(x) is convex for x a. The point x = a is called the vertex of the distribution. In particular, if F(x) is absolutely continuous, then the corresponding probability density function p(x) = F'(x) is nondecreasing for x a. In the present paper we shall establish the unimodality of a class of distribution functions which were studied by Linnik in [2 ]. He has shown that for any real a in the interval 0
Hierarchical distributed orchestration framework for multi-domain SDTNs

This paper presents an overarching orchestration architecture that combines hierarchical orchestration and distributed orchestration architectures for multicarrier and multi-domain software-defined transport networks (SDTNs). The objective of this study is to investigate how to combine the hierarchical topology discovery architecture and the distributed per-domain provisioning architecture, in which a set of child orchestrators (COs) enables end-to-end provisioning services in peer-to-peer environments while a parent orchestrator (PO) as well as the COs disseminate abstract inter- and intra-domain topological information between the PO and the COs. To analyze the proposed architecture, a hierarchical distributed orchestration framework was implemented and evaluated. The experimental and mathematical results demonstrate that the proposed architecture has advantages that enable fast dissemination of the abstract inter-domain topological information and evenly distribute the path computation and provisioning burden among all COs, thereby resulting in high scalability and efficiency for the orchestration of heterogeneous SDTN controllers and transport network infrastructure.
Effects of personality on the opioidergic modulation of the emotion warmth‐liking

Neurobiological research suggests there are discrete emotion systems, which are based on separate neural pathways with specific neurotransmitters (i.e., oxytocin, opioids). So far, autonomic regulation patterns of different positive emotions could not be unambiguously characterized. Warmth‐liking, as an emotion system, is activated during interpersonal interactions and close relationships. We postulated that warmth‐liking has a specific somatovisceral signature, which is, however, qualified by individual differences in personality and attachment style. Individual differences in personality and attachment style are postulated to contribute to μ‐opiate functioning. Forty‐eight females in a heterosexual relationship, selected on the basis of attachment reports, took part in a virtual ball‐tossing game with their partners and two confederates. Participants received either the competitive μ‐opioid antagonist naltrexone (25 mg) or a placebo in a randomized double‐blind design. Social exclusion during the game reduced feelings of warmth, increased feelings of anger, and increased blood pressure and left‐ventricular contractibility, whereas social inclusion was characterized by physiological quiescence. Further analyses revealed differential effects in self‐reported feelings as well as in cardiovascular parameters as a function of attachment style. Secure attachment predicted higher levels of warmth‐liking, physiological quiescence, and less negative feelings even during social exclusion. These findings can be interpreted as evidence for psychophysiological resilience. Furthermore, naltrexone reduced feelings of warmth and increased vasoconstriction during social inclusion, especially for securely bonded participants. These findings are remarkable hints for an opioidergic modulation of the interaction between emotion and personality. J. Comp. Neurol. 524:1712–1726, 2016. © 2015 Wiley Periodicals, Inc.
Use of a Panfungal PCR Assay for Detection of Fungal Pathogens in a Commercial Blood Culture System

ABSTRACT A panfungal PCR assay was used to evaluate the ability of the ESP blood culture system to detect fungemia. The results showed that the ESP system is reliable for the detection of fungi and showed the applicability of using a molecular-based assay as a potential rapid and reliable method for the identification of fungi.