Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiorespiratory Symptoms in Response to Physiological Arousal

Objective To develop a laboratory paradigm for assessing the tendency to amplify somatic symptoms and report bodily distress. Method Reports of four different cardiopulmonary symptoms were obtained during standardized, treadmill exercise, while the physiological parameters which induce these symptoms were simultaneously measured. Two indices were developed to compare symptom reporting across patients: symptom severity after reaching 80% of predicted, maximal exercise capacity; and the magnitude of physiological arousal necessary to induce an initial sensation of discomfort. Results Fifty-one medical outpatients with a chief complaint of palpitations were studied. Symptom distress at 80% of maximal exercise capacity was significantly associated with state anxiety and daily life stress. The complaint of "heart racing" first occurred at a significantly lower heart rate for patients who were older, more anxious, and reported more daily life stress. Measures of hypochondriasis, somatization, bodily amplification, and bodily absorption were not significantly associated with either symptom measure. Conclusions Standardized exercise testing may provide a suitable paradigm with which to study the tendency to amplify symptoms and to somatize. The distress reported by different subjects at 80% of maximal exercise capacity may be considered an index of the discomfort engendered by a standardized stimulus, whereas the point of onset of discomfort may be a measure of the patient's threshold for becoming symptomatic. These findings are not conclusive, but do suggest that patients who are more anxious and under more stress tend to report more intense cardiopulmonary symptoms at comparable levels of physiological arousal, and to have a lower threshold for experiencing discomfort.
Optimal dynamic load dispatching with the coordination of wind farm and AGC units

Due to the intermittent and uncertainty of wind power, power system net-load become more dynamic and unpredictive as the ramping events increase seriously with wind power penetration growing continuously. The change of net-load may deviate from the basis points of AGC, and more reserve capacity needed to be invoked to maintain the power balance, which will increase the operating cost of power system. To solve the problem, an dynamic load dispatching model and optimal strategy base on the AGC reserve capacity and marginal cost is proposed for the coordination dispatching of wind farm and AGC units. Within one minute time scale, the wind farm and AGC units adjust the operation set points according to the dynamic load dispatching results with the last updated wind power and load predication information. The participation factors of each AGC units and wind farm are optimized according to their marginal costs to cope with the net-load variation. From the results of New-England 39 bus test system, the dynamic net load can be tracked accurately and the operating cost can also be decreased at the same time.
Specialized subject domains thesauri formation with automated monitoring of market needs

We propose a method for the automated monitoring of multiple sources of data on the professional market needs to form thesauri and ontologies domains that are used in the educational process. We research the method for automated construction of learning ontologies based on computational linguistics algorithms, the method of analysis of lexical-semantic fields of texts corpora in Russian and English, frequency dictionaries of terms. We use the lexical database WordNet and terminological dictionaries to design the prototype ontology developed and uploaded into the software tool “OntoMASTER-Ontology” for refining by experts. The developed method is used for creating ontologies to support the learning process of students in the field of “Information systems and technologies”.
A Novel and Rapid PCR-Based Method for Genotyping Human Papillomaviruses in Clinical Samples

ABSTRACT Many human papillomavirus (HPV) genotypes are associated with cervical carcinoma. We demonstrate the utility of an innovative technique for genotyping of HPV in cervical tissue samples. This method provides an accurate means of identification of the specific HPV genotypes present in clinical specimens. By using the MY09-MY11 and the GP5+-GP6+ consensus primer pairs, HPV sequences were amplified by nested PCR from DNA isolated from cervical smear samples. This led to the production of an approximately 140-bp PCR product from the L1 (major capsid) gene of any of the HPVs present in the sample. PCR was performed with a deoxynucleoside triphosphate mixture which resulted in the incorporation of deoxyuridine into the amplified DNA product at positions where deoxythymidine would normally be incorporated at a frequency of about once or twice per strand. Following the PCR, the product was treated with an enzyme mix that contains uracil N-glycosylase (UNG) and endonuclease IV. UNG removes the uracil base from the nucleotide, and endonuclease IV cleaves the phosphodiester bond at this newly formed abasic site, producing fragments of various sizes. By having end labeled one of the amplification primers, a DNA ladder which is analogous to a “T-sequencing ladder” was produced upon electrophoresis of the products. By comparing this T-sequencing ladder to the known sequences of HPVs, the genotypes of unknown HPV isolates in samples were assigned. Data showing the utility of this technique for the rapid analysis of clinical samples are presented.
Entry of Vesicular Stomatitis Virus into L Cells

Early stages of the entry of vesicular stomatitis (VS) virus into L cells were followed by electron microscopy with the aid of ferritin antibody labeling. Cells which were infected at 0 C and incubated for 10 min at 37 C were reacted first with antiviral-antiferritin hybrid antibody and then with ferritin or fluorescein-labeled apoferritin. Extensive ferritin labeling of the cell surface was detected by both electron and fluorescence microscopy. The labeled regions of the cell surface were continuous with and indistinguishable from the rest of the host cell membrane, suggesting incorporation of viral antigens into the cell surface during viral penetration. Fusion of parental viral membrane with host cell membrane was further demonstrated by examining the localization of 3H-labeled viral structural proteins in cells infected at 0 C and incubated for short periods at 37 C. Viral nucleoprotein was found in a soluble fraction of the cells which was derived primarily from the cytoplasm, whereas a particulate fraction from the cells was enriched in viral envelope proteins. Cytoplasmic membrane was isolated from these cells, and this membrane contained viral envelope proteins. These results suggest that penetration by VS virus occurs by fusion of the viral and cellular membranes followed by release of nucleo-protein into the cytoplasm.
Sub-10 nm gate-all-around CMOS nanowire transistors on bulk Si substrate

In this paper, sub-10 nm gate-all-around (GAA) CMOS silicon nanowire field-effect transistors (SNWFET) on bulk Si substrate are fabricated successfully for the first time with 13-nm-diameter silicon nanowire channel. On-state currents of 1494/1054 muA/mum at off leakage currents of 102/6.44 nA/mum are obtained for N/PMOS, respectively. The impacts of nanowire diameter (DNW) and gate oxide thickness (TOX) as well S/D parasitic resistance (RSD) on performance are investigated in details.
Oxygen radicals in biological systems. Part B: Oxygen radicals and antioxidants.

Read more and get great! That's what the book enPDFd oxygen radicals in biological systems part b oxygen radicals and antioxidants will give for every reader to read this book. This is an on-line book provided in this website. Even this book becomes a choice of someone to read, many in the world also loves it so much. As what we talk, when you read more every page of this oxygen radicals in biological systems part b oxygen radicals and antioxidants, what you will obtain is something great.
Molecular markers predict outcome in squamous cell carcinoma of the head and neck after concomitant cisplatin‐based chemoradiation

Not all patients with squamous cell carcinomas of the head and neck (HNSCC) benefit from concurrent cisplatin‐based chemoradiation, but reliable predictive markers for outcome after chemoradiation are scarce. We have investigated potential prognostic biomarkers for outcome in a large group of patients. Ninety‐one tumor biopsies taken from consecutive HNSCC patients were evaluated for protein expression on a tissue microarray. Using immunohistochemistry, 18 biomarkers, involved in various cellular pathways were investigated. Univariable and multivariable proportional hazard analyses were performed to investigate associations between each individual marker and outcome. In addition, the global test was used to test all variables simultaneously and selected combinations of markers for an overall association with local control. Univariable analysis showed statistically significant increased relative risks of RB, P16 and MRP2 for local control and MDR1 and HIF‐1α for overall survival. MRP2, MDR1 and P16 levels were positively associated with outcome whereas RB and HIF‐1α had a negative relationship. Using Goeman's global testing no combination of markers was identified that was associated with local control. Grouping the markers according to their function revealed an association between a combination of 3 markers (P16, P21 and P27) and outcome (p = 0.05) was found. In the multivariable analysis, MRP2 and RB remained significant independent predictive markers for local control. This study describes the prognostic value of biomarkers for the outcome in patients uniformly treated with concurrent chemoradiation. MRP2 and RB were found to be associated with outcome in patients treated with concurrent chemoradiation. © 2009 Wiley‐Liss, Inc.
An Empirical Investigation of Underpricing in Chinese Ipos

In this paper, we empirically identify some of the causes of cross-sectional differences in underpricing of Chinese initial public offerings (IPOs) using data compiled for 308 firm-commitment A-share IPOs (available only to Chinese investors) and 57 B-share IPOs (available only to foreign investors). We first formulate and estimate a benchmark empirical model that relates IPO initial returns to variables widely used in studies of IPO underpricing. Then we test three hypotheses that may help explain the high A- share IPO underpricing in China. We find that IPO underpricing is the largest at the earliest stage of development of stock markets in China. The extraordinarily large IPO underpricing is at least partially due to a relatively small aggregate supply of shares. We also find that A-share IPO underpricing is better explained by a signaling model that relates IPO underpricing to subsequent seasoned equity offerings (SEOs) than by one linking government or employee ownership to equilibrium IPO underpricing. Issuers with larger IPO underpricing are more likely to raise larger amounts of capital through SEOs more quickly. The results support the notion that the primary purpose for Chinese firms going public is to raise capital, not to transfer ownership from state to private citizens. Moreover, we do not find any evidence that lottery mechanisms have contributed to the high IPO underpricing in China. Finally, we find some evidence that the difference in IPO underpricing among A and B shares can be explained by the differences in domestic and foreign investors' investment opportunities and investment sentiments.
Female Responses to Ancestral Advertisement Calls in T�ngara Frogs

Phylogenetic techniques were used to estimate and reconstruct advertisement calls at ancestral nodes. These calls were used to investigate the degree of preference of female t�ngara frogs (Physalaemus pustulosus) for both extant and ancestral calls. Females did not discriminate between calls of males of their own species and calls at their most recent ancestral node. They also recognized calls of three extant species and at four ancestral nodes as the signals of appropriate mates. Both shared ancestral history, and call convergence might differentially influence call preferences.
Functional Analysis of Genes for Biosynthesis of Pyocyanin and Phenazine-1-Carboxamide from Pseudomonas aeruginosa PAO1

ABSTRACT Two seven-gene phenazine biosynthetic loci were cloned fromPseudomonas aeruginosa PAO1. The operons, designatedphzA1B1C1D1E1F1G1 and phzA2B2C2D2E2F2G2, are homologous to previously studied phenazine biosynthetic operons from Pseudomonas fluorescens and Pseudomonas aureofaciens. Functional studies of phenazine-nonproducing strains of fluorescent pseudomonads indicated that each of the biosynthetic operons from P. aeruginosa is sufficient for production of a single compound, phenazine-1-carboxylic acid (PCA). Subsequent conversion of PCA to pyocyanin is mediated in P. aeruginosa by two novel phenazine-modifying genes,phzM and phzS, which encode putative phenazine-specific methyltransferase and flavin-containing monooxygenase, respectively. Expression of phzS alone inEscherichia coli or in enzymes, pyocyanin-nonproducingP. fluorescens resulted in conversion of PCA to 1-hydroxyphenazine. P. aeruginosa with insertionally inactivated phzM or phzS developed pyocyanin-deficient phenotypes. A third phenazine-modifying gene,phzH, which has a homologue in Pseudomonas chlororaphis, also was identified and was shown to control synthesis of phenazine-1-carboxamide from PCA in P. aeruginosa PAO1. Our results suggest that there is a complex pyocyanin biosynthetic pathway in P. aeruginosaconsisting of two core loci responsible for synthesis of PCA and three additional genes encoding unique enzymes involved in the conversion of PCA to pyocyanin, 1-hydroxyphenazine, and phenazine-1-carboxamide.
Student–teacher relationships and classroom climate in first grade: how do they relate to students’ stress regulation?

The present study involved 105 German students at the end of their first semester in elementary school in order to explore the stress that students may experience within the school environment, and how the relationship with the teacher buffers or exacerbates the stress. Student–teacher relationships were explored on both classroom and individual interaction levels. Classrooms were described by external observers in terms of teachers’ support and classroom organization. Teachers reported on the relationships with their students regarding closeness, conflict, and dependency, which determined four specific patterns of student–teacher relationships. Furthermore, saliva samples were taken on a Monday and a Friday of the same week (four times each day) to display diurnal cortisol profiles. These profiles were later evaluated by means of slopes and intercepts, reflecting students’ daily stress regulation. Comparisons between Monday and Friday profiles of the same student served as an estimate for the stress regulation throughout the week. Finally, associations between the profiles and the specific relationship patterns provided information on significant environmental conditions for students’ stress. Students in non-supportive, as compared to supportive, classrooms had flatter cortisol profiles, suggesting that classrooms of low quality hindered sufficient down-regulation of cortisol levels at both the beginning and the end of the week. Moreover, students with conflict-loaded relationships with their teachers were less able to appropriately down-regulate stress (especially on Fridays) than students with proximal-balanced relationships, showing the most optimal cortisol profiles.
ffi cient Data TLB Design for Embedded Processors

This paper presents a leakage efficient data TLB (Translation Look-aside Buffer) design for embedded processors. Due to the data locality in programs, data TLB references tend to hit only a small number of pages during short execution intervals. After dividing the overall execution time into smaller time slices, a leakage reduction mechanism is proposed to detect TLB entries which actually serve for virtual-to-physical address translations within each time slice. Thus, with the integration of the dual voltage supply technique, those TLB entries which are not used for address translations can be put into low leakage mode (with lower voltage supply) to save power. Evaluation results with eight MiBench programs show that the proposed design can reduce the leakage power of a data TLB by 37% on average, with performance degradation less than 0.01%. key words: leakage power, TLB, embedded processor
Multimodal variational analysis of quasiplanar waveguide discontinuities

Multimodal variational analysis will be presented for step discontinuity of some commonly used quasiplanar structures. Appreciable reduction in the computation time and computer memory space can be obtained by handling differently the modes which can be accessible from a certain distance to the discontinuity plane and those localized. An analysis program developed in FORTRAN on a PC computer will be applied to microstrip, finline and coplanar discontinuities, and compared to previously published results and experiments.
Proteomic profiling of KATP channel‐deficient hypertensive heart maps risk for maladaptive cardiomyopathic outcome

KCNJ11 null mutants, lacking Kir6.2 ATP‐sensitive K+ (KATP) channels, exhibit a marked susceptibility towards hypertension (HTN)‐induced heart failure. To gain insight into the molecular alterations induced by knockout of this metabolic sensor under hemodynamic stress, wild‐type (WT) and Kir6.2 knockout (Kir6.2‐KO) cardiac proteomes were profiled by comparative 2‐DE and Orbitrap MS. Despite equivalent systemic HTN produced by chronic hyperaldosteronism, 114 unique proteins were altered in Kir6.2‐KO compared to WT hearts. Bioinformatic analysis linked the primary biological function of the KATP channel‐dependent protein cohort to energetic metabolism (64% of proteins), followed by signaling infrastructure (36%) including oxidoreductases, stress‐related chaperones, processes supporting protein degradation, transcription and translation, and cytostructure. Mapped protein–protein relationships authenticated the primary impact on metabolic pathways, delineating the KATP channel‐dependent subproteome within a nonstochastic network. Iterative systems interrogation of the proteomic web prioritized heart‐specific adverse effects, i.e., “Cardiac Damage”, “Cardiac Enlargement”, and “Cardiac Fibrosis”, exposing a predisposition for the development of cardiomyopathic traits in the hypertensive Kir6.2‐KO. Validating this maladaptive forecast, phenotyping documented an aggravated myocardial contractile performance, a massive interstitial fibrosis and an exaggerated left ventricular size, all prognostic indices of poor outcome. Thus, Kir6.2 ablation engenders unfavorable proteomic remodeling in hypertensive hearts, providing a composite molecular substrate for pathologic stress‐associated cardiovascular disease.
Study on the effect of measles control programmes on periodic structures of disease epidemics in a large Chinese city

SUMMARY Measles is regarded as a disease that can be eliminated by vaccination; however, disease epidemics still occur in Wuhan, China. This study explored the effect of measles control programmes on the periodic structure of disease epidemics in Wuhan. The monthly reported measles incidence from 1953 to 2008 was divided into pre-vaccine range (1953–1965) and post-vaccine range (1966–2008). For the incidence in each range, spectral analysis was conducted and power spectral density (PSD) was obtained. In PSD for the pre-vaccine range, the most dominant spectral line was observed at a 2·0-year period, as in the case of Japan. It was confirmed that spectral lines of periodic modes longer than a 1-year cycle of the incidence rates behave in response to the introduction of measles control programmes. The investigation of periodic structures of measles epidemics will contribute to effective measles control programmes in Wuhan.
Economic Growth and FDI Inflows: A Stochastic Frontier Analysis

Despite plausible theoretical grounds for presuming a positive relationship between foreign direct investment inflows (FDI) and economic growth, existing empirical evidence on this nexus is inconclusive. In an effort to add to the empirical literature, this paper estimates the relationship between FDI and the rate of growth of GDP using a stochastic frontier model and employing panel data covering 45 countries over the period 1997 to 2004. We find that FDI inflows exert a positive impact on economic growth only in the presence of a highly skilled labour; corruption has a negative impact on economic growth; and trade openness increases economic growth by means of efficiency gains.
Implementation of Whole Slide Imaging for Clinical Purposes: Issues to Consider From the Perspective of Early Adopters.

CONTEXT - There is growing interest in the use of digital pathology, especially whole slide imaging, for diagnostic purposes. Many issues need to be considered when incorporating this technology into a clinical laboratory. The College of American Pathologists (CAP) established a Digital Pathology Committee to support the development of CAP programs related to digital pathology. One of its many initiatives was a panel discussion entitled "Implementing Whole-Slide Imaging for Clinical Use: What to Do and What to Avoid," given for 3 years at the CAP annual meetings starting in 2014. OBJECTIVES - To review major issues to consider when implementing whole slide imaging for clinical purposes as covered during the panel discussion. DESIGN - The views expressed and recommendations given are based primarily on the personal experience of the authors as early adopters of this technology. It is not intended to be an exhaustive review of digital pathology. RESULTS - Implementation is best approached in phases. Early efforts are directed toward identifying initial clinical applications and assembling an implementation team. Scanner selection should be based on intended use and budget. Recognizing pathologist concerns over the use of digital pathology for diagnostic purposes, ensuring adequate training, and performing appropriate validation studies will enhance adoption. Once implemented, the transition period from glass slide to image-based diagnostics will be associated with challenges, especially those related to a hybrid glass slide-digital slide workflow. CONCLUSIONS - With appropriate preparation, planning, and stepwise implementation, whole slide imaging can be used safely and reliably for frozen sections, consultation, quality assurance, and primary diagnosis.
Brain-behavior correlations in hemispatial neglect using CT and SPECT

Objective: Structural and functional lesion localization in patients with hemispatial neglect. Design: Location and severity of brain damage on CT and SPECT correlated with neglect performance as assessed with a battery of drawings, line bisection, and line and shape cancellation subtests. Patients: Participants included 120 consecutive stroke patients with a single right-hemisphere-damaged lesion on CT who were admitted to the Acute Stroke Care Unit at Sunnybrook Health Science Centre. Of these, 88 also had a SPECT. Results: On CT, 82 patients with neglect (compared with 38 without neglect) had more extensive damage in the parietal and sensorimotor cortex and white matter fiber bundles, including the posterior-superior longitudinal and inferior-frontal fasciculi (p < 0.05). Parietal and anterior cingulate damage best predicted neglect score using the CT data (p< 0.05), and regional blood flow in the parietal cortex best predicted neglect score using the SPECT data (p < 0.05) after controlling for the influence of age and lesion size on multiple linear regression. Conclusions: Damage in the parietal and anterior cingulate cortex and posterior white matter fiber bundles correlated with hemispatial neglect. Combining structural- and functional-imaging techniques with neurobehavioral analysis can elucidate brain-behavior relationships.