Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of rider weight and additional weight in Icelandic horses in tölt: part II. Stride parameters responses

This study investigated the effects of rider weight in the BW ratio (BWR) range common for Icelandic horses (20% to 35%), on stride parameters in tölt in Icelandic horses. The kinematics of eight experienced Icelandic school horses were measured during an incremental exercise test using a high-speed camera (300 frames/s). Each horse performed five phases (642 m each) in tölt at a BWR between rider (including saddle) and horse starting at 20% (BWR20) and increasing to 25% (BWR25), 30% (BWR30), 35% (BWR35) and finally 20% (BWR20b) was repeated. One professional rider rode all horses and weight (lead) was added to saddle and rider as needed. For each phase, eight strides at speed of 5.5 m/s were analyzed for stride duration, stride frequency, stride length, duty factor (DF), lateral advanced placement, lateral advanced liftoff, unipedal support (UPS), bipedal support (BPS) and height of front leg action. Stride length became shorter (Y=2.73−0.004x; P<0.01) and more frequent (Y=2.56+0.002x; P<0.001) with added weight. Duty factor and BPS increased with increased BWR (P<0.001), whereas UPS decreased (P<0.001). Lateral advanced timing of limb placement and liftoff and height of front leg action were not affected by BWR (P>0.05). In conclusion, increased BWR decreased stride length and increased DF proportionally to the same extent in all limbs, whereas BPS increased at the expense of decreased UPS. These changes can be expected to decrease tölt quality when subjectively evaluated according to the breeding goals for the Icelandic horse. However, beat, symmetry and height of front leg lifting were not affected by BWR.
Acute oligodendrocyte loss with persistent white matter injury in a third trimester equivalent mouse model of fetal alcohol spectrum disorder

Alcohol exposure during central nervous system (CNS) development can lead to fetal alcohol spectrum disorder (FASD). Human imaging studies have revealed significant white matter (WM) abnormalities linked to cognitive impairment in children with FASD; however, the underlying mechanisms remain unknown. Here, we evaluated both the acute and long‐term impacts of alcohol exposure on oligodendrocyte number and WM integrity in a third trimester‐equivalent mouse model of FASD, in which mouse pups were exposed to alcohol during the first 2 weeks of postnatal development. Our results demonstrate a 58% decrease in the number of mature oligodendrocytes (OLs) and a 75% decrease in the number of proliferating oligodendrocyte progenitor cells (OPCs) within the corpus callosum of alcohol‐exposed mice at postnatal day 16 (P16). Interestingly, neither mature OLs nor OPCs derived from the postnatal subventricular zone (SVZ) were numerically affected by alcohol exposure, indicating heterogeneity in susceptibility based on OL ontogenetic origin. Although mature OL and proliferating OPC numbers recovered by postnatal day 50 (P50), abnormalities in myelin protein expression and microstructure within the corpus callosum of alcohol‐exposed subjects persisted, as assessed by western immunoblotting of myelin basic protein (MBP; decreased expression) and MRI diffusion tensor imaging (DTI; decreased fractional anisotropy). These results indicate that third trimester‐equivalent alcohol exposure leads to an acute, albeit recoverable, decrease in OL lineage cell numbers, accompanied by enduring WM injury. Additionally, our finding of heterogeneity in alcohol susceptibility based on the developmental origin of OLs may have therapeutic implications in FASD and other disorders of WM development.
Heat Transfer Analysis of Heating Plate with Multiple Heat Sources

In the paper the 3D numerical study of transient heat transfer phenomenon on a solid plate with complex heat sources has been carried out. In order to validate the chosen numerical model, a set of thermographic measurements have been performed on a heating plate sample. The infrared camera provided a number of thermograms showing the development of transient temperature fields on the plate surface. A good agreement between thermograms and numerically obtained temperature fields has been achieved. Based upon validated numerical model, an approach involving thermographic measurements has been used to estimate the position of heat sources inside the plate. Numerically obtained temperature distributions have been used for calculation of effective transient heating output. The unsteady behavior of heating plate with complex heat sources has been numerically studied for different plate materials. It has been concluded that the temperature fields and transient heating outputs depend on physical properties of the plate material. However, when a steady state has been achieved, different plate materials give equivalent steady heating outputs despite of different temperature distributions.
Concordance between core needle biopsy and surgical specimen for oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status in breast cancer.

INTRODUCTION This study aimed to analyse the concordance rate, sensitivity, specificity, positive predictive value (PPV) and negative predictive value of core needle biopsy (CNB) and subsequent surgical specimen (SS) in assessing levels of oestrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor 2 (HER2/neu). It also evaluated the revised American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines for ER/PgR positivity. METHODS We analysed the breast cancer database of KK Women's and Children's Hospital, Singapore, from 1 June 2005 to 30 December 2012. Invasive breast cancer patients who had CNB and subsequent SS were included. RESULTS A total of 560 patients were included. The concordance of ER, PgR and HER2/neu positivity between CNB and SS was 96.1%, 89.1% and 96.8%, respectively. When the 'ER ≥ 10% positive' group was compared with the 'ER ≥ 1% positive' group, specificity increased from 79.7% to 92.5% and PPV increased from 93.9% to 97.5%. When the 'PgR ≥ 10% positive' group was compared with the 'PgR ≥ 1% positive' group, specificity increased from 84.2% to 89.3% and PPV improved from 89.7% to 92.9%. The revised ASCO/CAP guidelines decreased discordant results by > 50% for ER and by 18.2% for PgR. CONCLUSION CNB has high concordance with SS in the evaluation of the molecular profile of invasive breast cancer. Thus, molecular evaluation does not need to be repeated with SS except for ER-, PgR- and HER2/neu-negative CNB results. The revised ASCO/CAP guidelines resulted in more precise ER and PgR status on CNB.
The usefulness of body image tests in the prevention of eating disorders.

PURPOSE Individual psychological factors such as mental conditions and self-esteem and family relational factors are thought to be predisposing factors in the development of eating disorders. In this study, we conducted a survey of 12-15 year-old public junior high school students to extract factors related to abnormal eating behavior and determine what information could be used by schools to prevent eating disorders. METHOD Self-descriptive surveys were distributed and collected during homeroom time at school. The survey consisted of the 26-item Eating Attitude Test (EAT-26) to measure the degree of abnormal eating behavior, Stunkard, Sorensen and Schlusinger's Body Image Scale to determine predisposing factors, the Family Adaptability and Cohesion Scale III (FACES III), General Health Questionnaire (GHQ), and Rosenberg's Self-Esteem Scale. 483 students (263 boys and 220 girls) participated in the survey. School-year height and weight data was used to calculate BMI. RESULTS Approximately 7% of girls and 3% of boys showed clear indications of abnormal eating behavior. We found no direct relationship between abnormal eating behavior and family factors in this study, but an indirect relationship was suggested through other factors such as psychological complaints and self-esteem. There were relationships between abnormal eating behavior and the individual factors of psychological complaints, current and ideal body image, and low self-esteem. Furthermore, cluster analysis showed that there were students with high BMI who thought of themselves as fat, as well as students who perceived themselves as fat despite having average BMI. These students had a high frequency of abnormal eating behaviors, a great deal of psychological complaints, and low self-esteem. DISCUSSION An understanding of BMI, along with body image, is essential for students who feel that they are overweight. Schools can practice preventative education by teaching these students about healthy body weight and by screening for the eating disorders that have become so rampant in our thin-worshiping culture.
Influence of ambient humidity on the attachment ability of ladybird beetles (Coccinella septempunctata)

Many insects possess adhesive foot pads, which enable them to scale smooth vertical surfaces. The function of these organs may be highly affected by environmental conditions. Ladybird beetles (Coccinellidae) possess dense tarsal soles of tenent setae, supplemented with an adhesive fluid. We studied the attachment ability of the seven-spotted ladybird beetle (Coccinella septempunctata) at different humidities by horizontal traction experiments. We found that both low (15%) and high (99%) relative humidities lead to a decrease of attachment ability. The significantly highest attachment forces were revealed at 60% humidity. This relationship was found both in female and male beetles, despite of a deviating structure of adhesive setae and a significant difference in forces between sexes. These findings demonstrate that not only dry adhesive setae are affected by ambient humidity, but also setae that stick due to the capillarity of an oily secretion.
Micronutrient Intake and the Contribution of Dietary Supplements in Hispanic Infants

ABSTRACT To calculate micronutrient adequacy among infants and toddlers and to determine the contribution of dietary supplements to this adequacy, micronutrient intake was assessed using two nonconsecutive 24-hour recalls in a sample of 296 infants aged 0–24 months. Micronutrient intake was calculated from foods and beverages and from supplements and compared between nonusers and users of supplements. Percentages of children below the Dietary Reference Intake (DRI) and above the tolerable upper limit intake (UL) were also compared between groups. A total of 241 participants had complete data. The prevalence of dietary supplement use among the sample was 15%. Mean intake of all micronutrients from foods and beverages was similar between nonusers and users of supplements (p > .05) but significantly higher for the following vitamins when supplements were included: D, E, B1, B2, B3, and B6 (p < .05). From foods only, the nutrients with highest percentage of children below the DRI were vitamins D and E and potassium. When supplements were included, this percentage significantly decreased among users compared to nonusers (p < .05) for vitamins D and E. From foods, the UL was exceeded for magnesium, zinc, and vitamin B3. These were similar when supplements were added. Supplements significantly increased the intake of some vitamins. Vitamins D and E had the highest percentage of children below the DRI, which was partly corrected with the use of supplements. The UL was exceeded for magnesium, zinc, and vitamin B3 in many children. It is important to understand these patterns as they may be indicative of future nutritional deficiencies and excesses.
A comparison of the electrocortical response to monetary and social reward

Abstract Affective science research on reward processing has primarily focused on monetary rewards. There has been a growing interest in evaluating the neural basis of social decision-making and reward processing. The present study employed a within-subject design and compared the reward positivity (RewP), an event-related potential component that is present following favorable feedback and absent or reduced following unfavorable feedback, during monetary and social reward tasks. Specifically, 114 participants (75 females) completed a monetary reward task and a novel social reward task that were matched on trial structure, timing, and feedback stimuli in a counterbalanced order. Results indicated that the monetary and social RewP were of similar magnitude, positively correlated and demonstrated comparable psychometric properties, including reliability and dependability. Across both the monetary and social tasks, women demonstrated a greater RewP compared with men. This study provides a novel methodological approach toward examining the electrocortical response to social reward that is comparable to monetary reward.
Using simulation as a learning experience in clinical teams to learn about palliative and end-of-life care: A literature review

ABSTRACT Simulation has been shown to improve the preparedness of practitioners in acute care. In this review, the authors evaluate using simulation to prepare practitioners to deliver palliative care in multidisciplinary teams. The Joanna Briggs Institute approach was used and seventeen studies selected. The thematic analysis of the literature fitted well with Gabby, Le May, Connell, and Klein’s (2014) pyramid approach to health improvement suggesting that simulation can be used in teams to learn technical, soft and learning skills of delivering palliative care. The analysis does not indicate how learning each of these skills interacts nor if simulations in teams should be repeated, or how often.
Estimating fatigue endurance limits of flexible airfield pavements

Abstract In perpetual pavements, damage from bottom-up cracking can be limited to the top surface lift through using a very thick surface layer or a binder-rich intermediate layer. This can be attained by maintaining tensile strains at the bottom of the hot-mix asphalt (HMA) layer below a certain value known as the fatigue endurance limit (FEL). This paper presents a method for estimating a strain-based FEL for flexible airfield pavements. The proposed method is based on the concept that a 50% reduction in HMA layer modulus would indicate initiation of fatigue cracking. Falling weight deflectometer (FWD) testing results, collected from National Airport Pavement Test Facility (NAPTF) flexible pavement sections, were analyzed to determine at which loading pass each section had a 50% reduction in HMA layer modulus (Nf50). NAPTF tensile strain data were also used to determine the tensile strain at Nf50 for each pavement section by averaging the peak tensile strains. The proposed approach was validated by comparing its results to those obtained using a common FEL estimation model known as the rate of dissipated energy change (RDEC) model. To further verify the results of the proposed approach, peak tensile strain was plotted vs. number of loading cycles for all sensors. Using these plots, the peak tensile strain at which the variability in the strain gauge data increased was used as an estimate of a possible FEL. The Nf50 tensile strains estimated using the proposed method were comparable to the values determined from RDEC and variability approaches.
Transparent flow migration for NFV

NFV together with SDN provides the flexibility for NFs in the way that they are deployed and managed. The flexibility enables dynamical scale in and scale out through migrating in-process flows among NFs. Due to stateful packet processing in NFs, flow migration has to guarantee loss-free and order-preserving for both flow states and packets. Existing frameworks closely coupled state transfer and packets migration, and thus fail to achieve safe and efficient migration with low overhead. This paper presents our design and implementation of a distributed flow migration framework, Transparent Flow Migration (TFM). TFM completely decouples the state transfer and packets migrations. The decoupling allows us to optimize the two processes separately and run them in parallel. TFM implements various optimizations through the TFM box, a shim layer providing transparent packet migration to NFs. Our evaluation shows that TFM guarantees loss-free and order-preserving for both scale-in and scale-out flow migration, and outperforms existing approaches with 3× smaller migration time. Besides, TFM uses small overhead and has very limited impacts on throughput of live TCP flows.
Implementation of change data capture in ETL process for data warehouse using HDFS and apache spark

This study aims to increase ETL process efficiency »ud reduce processing time by applying the method of Change Data Capture (CDC) in distributed system using Hadoop Distributed file System (HDFS) and Apache Spark in the data warehouse of Learning Analytics system of Universitas Indonesia. Usually, increases in I lie number of records in the data source result in an increase in ETL processing time for the data warehouse system. This condition occurs as a result of inefficient ETL process using the full load method. Using the tull load method, ETL has to process the same number of records as the number of records in the data sources. The proposed ETL model design with the application of CDC method using HDFS and Apache Spark can reduce the amount of data in the ETL process. Consequently, the process becomes more efficient and the ETL processing time Is reduced approximately 53% in average.
An Integrated Transcriptomics and Proteomics Analysis of the Secretome of the Helminth Pathogen Fasciola hepatica

To infect their mammalian hosts, Fasciola hepatica larvae must penetrate and traverse the intestinal wall of the duodenum, move through the peritoneum, and penetrate the liver. After migrating through and feeding on the liver, causing extensive tissue damage, the parasites move to their final niche in the bile ducts where they mature and produce eggs. Here we integrated a transcriptomics and proteomics approach to profile Fasciola secretory proteins that are involved in host-pathogen interactions and to correlate changes in their expression with the migration of the parasite. Prediction of F. hepatica secretory proteins from 14,031 expressed sequence tags (ESTs) available from the Wellcome Trust Sanger Centre using the semiautomated EST2Secretome pipeline showed that the major components of adult parasite secretions are proteolytic enzymes including cathepsin L, cathepsin B, and asparaginyl endopeptidase cysteine proteases as well as novel trypsin-like serine proteases and carboxypeptidases. Proteomics analysis of proteins secreted by infective larvae, immature flukes, and adult F. hepatica showed that these proteases are developmentally regulated and correlate with the passage of the parasite through host tissues and its encounters with different host macromolecules. Proteases such as FhCL3 and cathepsin B have specific functions in larvae activation and intestinal wall penetration, whereas FhCL1, FhCL2, and FhCL5 are required for liver penetration and tissue and blood feeding. Besides proteases, the parasites secrete an array of antioxidants that are also highly regulated according to their migration through host tissues. However, whereas the proteases of F. hepatica are secreted into the parasite gut via a classical endoplasmic reticulum/Golgi pathway, we speculate that the antioxidants, which all lack a signal sequence, are released via a non-classical trans-tegumental pathway.
Engineering of synthetic, stress-responsive yeast promoters

Advances in synthetic biology and our understanding of the rules of promoter architecture have led to the development of diverse synthetic constitutive and inducible promoters in eukaryotes and prokaryotes. However, the design of promoters inducible by specific endogenous or environmental conditions is still rarely undertaken. In this study, we engineered and characterized a set of strong, synthetic promoters for budding yeast Saccharomyces cerevisiae that are inducible under acidic conditions (pH ≤ 3). Using available expression and transcription factor binding data, literature on transcriptional regulation, and known rules of promoter architecture we improved the low-pH performance of the YGP1 promoter by modifying transcription factor binding sites in its upstream activation sequence. The engineering strategy outlined for the YGP1 promoter was subsequently applied to create a response to low pH in the unrelated CCW14 promoter. We applied our best promoter variants to low-pH fermentations, enabling ten-fold increased production of lactic acid compared to titres obtained with the commonly used, native TEF1 promoter. Our findings outline and validate a general strategy to iteratively design and engineer synthetic yeast promoters inducible to environmental conditions or stresses of interest.
Bacteriophages Targeting Adherent Invasive Escherichia coli Strains as a Promising New Treatment for Crohn’s Disease

Background and Aims Adherent invasive Escherichia coli [AIEC] are abnormally predominant on the ileal mucosa of Crohn's disease [CD] patients. They bind to the CEACAM6 receptor expressed on the surface of epithelial cells. We aimed to assess the potential of bacteriophages, viruses infecting bacteria, to decrease the levels of AIEC bacteria associated with the intestinal mucosa. Methods We combined ex vivo and in vivo experiments with murine and human intestinal samples to quantify the ability of virulent bacteriophages to target the prototype AIEC strain LF82. Results We found that three virulent bacteriophages were able to replicate in ileal, caecal and colonic sections and faeces homogenates from murine gut samples colonised with the prototype AIEC strain LF82. A single day of per os treatment with the three bacteriophages cocktail given to LF82-colonised CEABAC10 transgenic mice, expressing the human CEACAM6 receptor for AIEC, decreased significantly the number of AIEC in faeces and in the adherent flora of intestinal sections. In addition, a single dose of the cocktail reduced dextran sodium sulphate-induced colitis symptoms on conventional mice colonised with the strain LF82 over a 2-week period. The cocktail targeted also LF82 bacteria in homogenates of ileal biopsies taken from CD patients. Conclusions These findings demonstrate that bacteriophages are a new treatment option for targeting AIEC in CD patients and represent a strong basis for a clinical trial evaluation.
Behavior analysis for elderly care using a network of low-resolution visual sensors

Abstract. Recent advancements in visual sensor technologies have made behavior analysis practical for in-home monitoring systems. The current in-home monitoring systems face several challenges: (1) visual sensor calibration is a difficult task and not practical in real-life because of the need for recalibration when the visual sensors are moved accidentally by a caregiver or the senior citizen, (2) privacy concerns, and (3) the high hardware installation cost. We propose to use a network of cheap low-resolution visual sensors (30×30 pixels) for long-term behavior analysis. The behavior analysis starts by visual feature selection based on foreground/background detection to track the motion level in each visual sensor. Then a hidden Markov model (HMM) is used to estimate the user’s locations without calibration. Finally, an activity discovery approach is proposed using spatial and temporal contexts. We performed experiments on 10 months of real-life data. We show that the HMM approach outperforms the k-nearest neighbor classifier against ground truth for 30 days. Our framework is able to discover 13 activities of daily livings (ADL parameters). More specifically, we analyze mobility patterns and some of the key ADL parameters to detect increasing or decreasing health conditions.