Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantitative Trait Loci Associated With Adventitious Shoot Formation in Tissue Culture and the Program of Shoot Development in Arabidopsis

Arabidopsis ecotypes, Columbia (Col) and Landsberg erecta (Ler), differ in their capacity to regenerate shoots in culture, as do many other cultivars and varieties of the same plant species. Recombinant inbred (RI) lines derived from a cross of Col × Ler were scored for shoot regeneration, and the Arabidopsis genome was scanned using composite interval mapping for loci associated with shoot regeneration. Three QTL were identified—a major one on chromosome 5 in which the Col parent contributed the superior allele and two minor QTL on chromosomes 1 and 4 in which the Ler parent contributed the superior alleles. The RI lines were binned into genotypic pools to isolate the effects of the major QTL on chromosome 5 while holding the minor QTL constant. To identify genes with expression levels that are associated with the allelic state of the major QTL on chromosome 5, oligonucleotide array expression patterns for genes in the LLC pool (Ler alleles at the minor QTL and a Col allele at the major QTL) were compared to those in the LLL pool (Ler alleles at all QTL). The genes that were significantly differentially expressed between the two pools included several encoding transcription factors and signaling or transposon-related proteins.
Teachers Competency in the Teaching and Learning of Chemistry Practical

This study aims to explore the contribution of teachers' competency in teaching and learning practical chemistry from the interrelated aspects of designing, planning, implementing and evaluating practical training or experiment in improving the quality and standards of teaching and learning practical chemistry. This is a survey using a questionnaire as the main instrument to determine the four aspects of the aforementioned competencies. The samples are randomly selected consisting of 234 chemistry teachers in Riau, Indonesia. Data were analyzed using multiple regression to assess the contribution of the four components of competency to analyze the quality of teaching and learning for practical chemistry. The findings show that the level of competency in all aspects of designing, planning, implementing and evaluating of practical training is at the moderate level. Solid and strategic efforts need to be taken to increase teachers’ competency and acquisition of more sophisticated laboratory materials should be done. Teachers’ creativity and initiative in making practical science to be more meaningful will be discussed in this paper. DOI: 10.5901/mjss.2014. v5n8p312
The Relationship Between Variations in Antipsychotic Prescribing Across Nursing Homes and Short-Term Mortality: Quality of Care Implications

Background:High rates of antipsychotic drug prescribing in nursing homes can signal poor quality processes, but also raise concerns about drug safety due to the mortality risk of this therapy. Determining the extent to which variations in antipsychotic use are a symptom of facility-level quality problems as compared with a drug safety issue is important for selecting the correct interventions to effect change. Objective:To determine whether nursing homes with higher rates of antipsychotic dispensing had higher rates of short-term mortality among their residents. Methods:This population-based study examined 60,105 older adults newly admitted to nursing homes in Ontario between April 1, 2000 and March 31, 2004. Using adjusted Cox proportional hazard models, we explored the relationship between facility-level dispensing rates and mortality, controlling for resident characteristics. Facilities were grouped into quintiles according to mean antipsychotic rate. All-cause mortality at 30 and 120 days after admission was stratified by recent hospital discharge and analyzed by quintile. Results:Average antipsychotic dispensing ranged from 11.6% in the lowest quintile to 30.0% in the highest. Among residents with no recent hospitalization, all-cause mortality at 30 days was 2.5% in the lowest compared with 3.3% in the highest quintile (adjusted hazard ratio: 1.28, confidence interval: 1.06–1.56) and at 120 days was 9.3% compared with 11.7% (adjusted hazard ratio: 1.25, confidence interval: 1.13–1.39). Conclusion:Residents were at increased risk of death simply by being admitted to a facility with a higher intensity of antipsychotic drug use, despite similar clinical characteristics at admission.
Does a quality improvement intervention for anxiety result in differential outcomes for lower-income patients?

OBJECTIVE The authors examined the effects of a collaborative care intervention for anxiety disorders in primary care on lower-income participants relative to those with higher incomes. They hypothesized that lower-income individuals would show less improvement or improve at a lower rate, given that they would experience greater economic stress over the treatment course. An alternative hypothesis was that lower-income participants would improve at a higher rate because the intervention facilitates access to evidence-based treatment, which typically is less available to persons with lower incomes. METHOD Baseline demographic and clinical characteristics of patients with lower (N=287) and higher (N=717) income were compared using t tests and chi-square tests for continuous and categorical variables, respectively. For the longitudinal analysis of intervention effects by income group, the outcome measures were jointly modeled at baseline and at 6, 12, and 18 months by study site, income, time, intervention, time and intervention, income and time, income and intervention, and time, intervention, and income. RESULTS Although lower-income participants were more ill and had greater disability at baseline than those with higher incomes, the two income groups were similar in clinical response. The lower-income participants experienced a comparable degree of clinical improvement, despite receiving fewer treatment sessions, less relapse prevention, and less continuous care. CONCLUSIONS These findings contribute to the ongoing discussion as to whether or not, and to what extent, quality improvement interventions work equally well across income groups or require tailoring for specific vulnerable populations.
Combining Design Science and Design Research Perspectives--Findings of Three Prototyping Projects

A challenge that information system researchers face in general is to combine the goals of generating new scientific knowledge while at the same time producing practically relevant research results, e.g., in the form of IT artifacts. To combine both, researchers and practitioners need to collaborate to develop and employ methods that enable both the systematic generation of scientific insights as well as the knowledge exchange between academia and industry. In this paper, we present the findings of a research project where we entered into an industry-academic collaboration involving three software development projects. We used a design science research approach to observe and accompany the project and to guide the scientific discovery process. In the course of our research process we developed an innovative research model that integrates our experiences from a research project with existing design science research models.
On the forward problem of EEG cortical imaging by means of finite element method

Cortical imaging technique (CIT) is an effective spatial enhancement approach to noninvasively image dynamic brain activity with high spatial resolution. The accuracy of forward problem in CIT has an importance on the accuracy of estimated cortical potentials. In this paper, we investigate finite-element-algorithms relating the cortical potentials to the scalp potentials. The numerical accuracy of the FEM algorithm being considered was assessed by computer simulations. The present simulation results suggest that the present FEM model has the similar accuracy as compared with the conventional model, but offers convenience in the application. The present algorithm has been tested in a realistic geometry head model.
Mining maritime vessel traffic: Promises, challenges, techniques

This paper discusses machine learning and data mining approaches to analyzing maritime vessel traffic based on the Automated Information System (AIS). We review recent efforts to apply machine learning techniques to AIS data and put them in the context of the challenges posed by the need for both algorithmic performance generalization and interpretability of the results in real-world maritime Situational Awareness settings. We also present preliminary work on discovering and characterizing vessel stationary areas using an unsupervised spatial clustering algorithm.
Projet OGIVE. Outils d’aide à la Gestion Intégrée et à la Valorisation des Ecosystèmes conchylicoles de Basse-Normandie. Rapport final d’activités - Phase I (2005-2008)

L’objectif general du projet OGIVE est d’acquerir des connaissances sur le fonctionnement des ecosystemes conchylicoles de Basse-Normandie dans le but d’etablir une plateforme de donnees communes a l’ensemble des partenaires du projet. Ces connaissances sont ensuite utilisees pour developper des outils novateurs permettant de fournir des avis et expertises aux gestionnaires du Domaine Public Maritime. Le projet a ainsi pour objectif de contribuer au developpement durable de la filiere conchylicole en Basse-Normandie en optimisant la production conchylicole et en preservant la qualite environnementale des ecosystemes qui supportent cette activite. Le projet OGIVE a ete structure initialement autour du developpement de trois outils : 1) Un outil empirique sous Systeme d’Information Geographique destine a repondre aux questions de gestion relatives aux restructurations a l’echelle d’une concession, 2) Un outil de modelisation non spatialise (i.e. modele d’ecosysteme biologique) permettant d’estimer la capacite de support trophique (i.e. biomasse maximale a mettre en exploitation compte tenu de la nourriture disponible dans l’ecosysteme) de chacun des sites de production bas-normands, 3) Un outil de modelisation spatialise (i.e. modele d’ecosysteme couplant les processus physiques & biologiques) permettant d’affiner les estimations de capacite de support trophique et de tester differents scenarios de reamenagement des zones d’elevage. Le present rapport est dedie a la presentation des resultats acquis au cours de la premiere phase du projet (2005-2008).
ICFHR2014 Competition on Word Recognition from Historical Documents: ANncestry Word REcognition from Segmented Historical Documents (ANWRESH)

This paper describes the ANWRESH (Anncestry Word Recognition from Segmented Historical Documents)competition held at the 14th International Conference on Frontiers in Handwriting Recognition (ICFHR-2014). This competition uses the ANWRESH dataset selected from the 1930 US Census collection including word bounding box and field lexicon data. Five teams submitted systems for recognizing six fields including Surname, Given Name(s), Age, Birth Place, Marital Status, and Relation. Results are reported, along with brief descriptions of each system.
Provably secure certificate‐based key‐insulated signature scheme

Certificate‐based signature computation is often performed on insecure devices where the signature key is easy to be exposed. To reduce the influence of key exposure, we introduce key‐insulated mechanism into certificate‐based cryptography and formalize the notion and security model of the certificate‐based key‐insulated signature scheme. We then present a certificate‐based key‐insulated signature scheme, which is proven to be existentially unforgeable against adaptive chosen message attacks in the random oracle model. The proposed scheme has potential applications in trusted computing. Copyright © 2013 John Wiley & Sons, Ltd.
A 2.0–5.5 GHz Wide Bandwidth Ring-Based Digital Fractional-N PLL With Extended Range Multi-Modulus Divider

Phase noise performance of ring oscillator based digital fractional-N phase-locked loops (FNPLLs) is severely compromised by conflicting bandwidth requirements to simultaneously suppress oscillator phase and quantization noise introduced by the time-to-digital converter (TDC), ΔΣ fractional divider, and digital-to-analog converter (DAC). As a consequence, their figure-of-merit (FoMJ) that quantifies the power-jitter tradeoff is at least 25 dB worse than their LC-oscillator-based FNPLL counterparts. This paper seeks to close this performance gap by extending PLL bandwidth (BW) using quantization noise cancellation techniques and by employing a dual-path digital loop filter to suppress the detrimental impact of DAC quantization noise. Fabricated in 65 nm CMOS process, the proposed FNPLL operates over a wide frequency range of 2.0-5.5 GHz using a modified extended range multi-modulus divider with seamless switching. The proposed digital FNPLL achieves 1.9 psrms integrated jitter while consuming only 4 mW at 5 GHz output. The measured in-band phase noise is better than -96 dBc/Hz at 1 MHz offset. The proposed FNPLL achieves wide BW up to 6 MHz using a 50 MHz reference and its FoMJ is -228.5 dB, which is the best among all reported ring-based FNPLLs.
Review of "Algorithm design: foundations, analysis and internet examples" by Michael T. Goodrich and Roberto Tamassia. John Wiley & Sons, Inc. 2001.

curriculum. But the instructor who plans such a course must spend some time preparing suitable additional exercises. Review9 of Algorithm Design: Foundations, Analysis and Internet Examples by Michael T. Goodrich and Roberto Tamassia Publisher: John Wiley & Sons, Inc. 720 pages, $74.95 new, $40.00 used, on Amazon Paperback, 2001 Reviewer: Pavol Navrat, Slovak University of Technology in Bratislava, Slovakia
Post-implantation syndrome after endovascular repair of aortic aneurysms: need for postdischarge surveillance.

OBJECTIVES To present the consequences and the need for readmission due to a vigorous inflammatory response in six patients who underwent endovascular repair of aortic aneurysms and developed post-implantation syndrome (PIS), during the postoperative period. METHODS From January 2007 to December 2009, 162 patients underwent endovascular repair of an aortic aneurysm. PIS was recorded in 49 patients. Among these, we present six patients who developed a systemic inflammatory response syndrome (SIRS) after discharge from hospital, which led to readmission within the first 30 postoperative days. RESULTS Five patients were treated for asymptomatic infrarenal abdominal aortic aneurysm and one for a thoracic one. All patients were discharged from hospital in the absence of any complications, fever or leukocytosis, but several days later they developed features of SIRS leading to readmission, even to the intensive care unit in two of them. After the administration of anti-inflammatory drugs all patients showed a complete recovery and finally left hospital several days later. CONCLUSIONS In some patients, the initial inflammatory response following endovascular aortic aneurysm repair is not always spontaneously attenuated and could lead to the development of SIRS even several days after the operation. It seems reasonable that patients developing PIS after endovascular aneurysm repair might be better kept under surveillance for the first postoperative month.
Liprin-α1 promotes cell spreading on the extracellular matrix by affecting the distribution of activated integrins

Integrin activation is needed to link the extracellular matrix with the actin cytoskeleton during cell motility. Protrusion requires coordination of actin dynamics with focal-adhesion turnover. We report that the adaptor protein liprin-α1 is stably associated with the cell membrane. Lipin-α1 shows a localization that is distinct from that of activated β1 integrins at the edge of spreading cells. Depletion of liprin-α1 inhibits the spreading of COS7 cells on fibronectin by affecting lamellipodia formation, whereas its overexpression enhances spreading, and lamellipodia and focal-adhesion formation at the cell edge. Cooperation between liprin-α1 and talin is needed, because either talin or liprin depletion prevents spreading in the presence of the other protein. The effects of liprin on spreading, but not its effects in the reorganization of the cell edge, are dependent on its interaction with leukocyte common antigen-related tyrosine phosphatase receptors. Therefore, liprin is an essential regulator of cell motility that contributes to the effectiveness of cell-edge protrusion.
The situation of Romanian HIV-positive adolescents: results from the first national representative survey

Abstract Young people are one of the groups most affected by HIV/AIDS worldwide. For over a decade after the fall of the Communism, Romania accounted for over 50% of the total pediatric cases in Europe (Buzducea & Lazăr, 2008; Mărdărescu, 2008) with an estimated 10,000 children infected in hospital settings (nosocomial) between 1986 and 1992. Although about 3000 of these children died of AIDS, many of them have survived almost 20 years. This paper presents the methodology and the results of the first representative research on adolescents living with HIV/AIDS registered with medical services in Romania (N=534 subjects) attending the nine Regional Centers for HIV/AIDS Surveillance (August–October 2006). The general objective of the research was to assess the situation of 15–19 year-old young people living with HIV/AIDS (PLWHA) from Romania and the dynamics of their risk behaviors in respect to virus transmission (O'Leary, 2002). Based on the research findings, the implications for practice are discussed and specific interventions are recommended to better respond the needs of young PLWHA.
Semantic fuzzy mining: Enhancement of process models and event logs analysis from syntactic to conceptual level

Semantic-based process mining is a useful technique towards improving information values of process models and analysis by means of conceptualization. The conceptual system of analysis allows the meaning of process elements to be enhanced through the use of property characteristics and classification of discoverable entities, to generate inference knowledge that can be used to determine useful patterns and predict future outcomes. The work in this paper presents a Semantic-Fuzzy mining approach that makes use of labels within event log about real-time process to provide a method which allows for mining and improved process analysis of the resulting process models through semantic – annotation, representation and reasoning. Qualitatively, the study shows by using a case study of Learning Process – how data from various process domains can be extracted, semantically prepared, and transformed into mining executable formats to support the discovery, monitoring and enhancement of real-time domain processes through further semantic analysis of the discovered models. Also, the paper quantitatively assess the level of accuracy of the classification results to predict behaviours of unobserved instances within the process knowledge-base by determing which traces are fitting or not fitting the discovered model by using a training set and test log for the cross-validation experiment. Accordingly, the work looks at the sophistication of the proposed semantic-based approach and the discovered models, validation of the classification results and their influence compared to other existing benchmark techniques and algorithms for process mining. The experimental results and data validation ends with the supposition that a system which is formally encoded with semantic labelling (annotation), semantic representation (ontology) and semantic reasoning (reasoner) has the capability to lift process mining analysis and outcomes from the syntactic level to a much more conceptual level, resulting in a mining approach that is able to induce new knowledge based on previously unobserved behaviours and a more intuitive and easy way to envisage the relationships between the process instances found within the available event data logs and the discovered process
Transitioning outcome measures: relationship between the CMTPedS and CMTNSv2 in children, adolescents, and young adults with Charcot‐Marie‐Tooth disease

Long‐term studies of Charcot‐Marie‐Tooth (CMT) disease across the entire lifespan require stable endpoints that measure the same underlying construct (e.g., disability). The aim of this study was to assess the relationship between the CMT Pediatric Scale (CMTPedS) and the adult CMT Neuropathy Score (CMTNSv2) in 203 children, adolescents, and young adults with CMT. There was a moderate curvilinear correlation between the CMTPedS and the CMTNSv2 (Spearman's rho ρ = 0.716, p < 0.0001), although there appears to be a floor effect of the CMTNSv2 in patients with a milder CMT phenotype. Univariate analyses indicate that the relationship between the CMTPedS and CMTNSv2 scores improves with worsening disease severity and advancing age. Although one universal scale throughout life would be ideal, our data supports the transition from the CMTPedS in childhood to the CMTNSv2 in adulthood as a continuum of measuring lifelong disability in patients with CMT.
STUDIES WITH RADIOACTIVE DI-AZO DYES. II. THE SYNTHESIS AND PROPERTIES OF RADIOACTIVE DI-BROM TRYPAN BLUE AND RADIOACTIVE DI-BROM EVANS BLUE.

Investigations from these laboratories ( 1, 2) deal with the accumulation of radioactive di-brom dyes in abscesses and tumors. The radio-dyes are also useful for studies of capillary permeability in so far as their permeation from blood into lymph, too slight to be detected visually in the normal animal, may be quantitatively measured on samples of lymph (3). Dyes of this group make a bond with plasma protein (4), becoming preferentially associated with albumin, and they therefore constitute a radioactive "tracer" for protein under certain experimental conditions. In view of the interest attaching to such matters, as well as the fact that a large group of chemically related but biologically highly varying compounds-the di-azo dyes-may be made radioactive by this technique, the present paper will describe the method used in rendering the molecule radioactive. Chemical and biological properties of the brominated dyes will also be discussed. The molecule is made radioactive by the incorporation of two atoms of radioactive bromine in the di-phenyl portion of the molecule (Figure 1). Bromine atoms, so incorporated into an aromatic ring, do not ionize or dissociate. Thus in using the radio-dye for "tracer" experiments, measurements for radio-bromine constitute measurements for the dye molecule as a whole. The steps involved in this synthesis are as follows: