Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimization of Acquisition Parameters of Diffusion-Tensor Magnetic Resonance Imaging in the Spinal Cord

Objective:The purpose of this study was to optimize imaging parameters for diffusion tensor imaging (DTI) of the cervical spinal cord using a recently developed sensitivity-encoded (SENSE) imaging technique, which can substantially reduce susceptibility artifacts. Materials and Methods:One hundred twenty sets of DTIs were performed of the cervical spinal cord in 40 normal volunteers, using a SENSE-based echo-planar imaging technique with different parameters (b-values, numbers of diffusion gradient directions, number of excitations, and slice thickness) in a stepwise approach. In step 1, DTI was performed of the cervical spinal cord with different b-values 500, 700, 900 seconds/mm2; then with different numbers of diffusion gradient directions 6, 15, 32 in step 2; different number of excitations 1, 3, 5 in step 3; and different slice thicknesses 2, 3, 4 mm in step 4. In each step, 30 sets of DTIs were obtained from 10 volunteers. To determine the optimal imaging parameters, 3 radiologists evaluated the qualities of fractional anisotropy (FA) maps and color FA maps by visual analysis. The number of reconstructed fibers was measured for quantitative analysis. All qualitative and quantitative comparisons were analyzed by statistical methods using the Friedmann test and the Wilcoxon signed rank test. Results:In step 1, DTIs using a b-value of 900 seconds/mm2 showed the highest number of reconstructed fibers and the best image quality of FA map and color map. In step 2, the use of 15 or 32 directions demonstrated better quality DTIs than 6 directions. No significant difference was evident between the quality of DTI with 15 directions and that with 32 directions. The scan time of DTI with 15 directions was shorter than with 32 directions. In step 3, as the number of excitations increased, the number of reconstructed fibers increased significantly and the image quality of the FA map and the color map improved significantly. In step 4, the numbers of reconstructed fibers were significantly the highest with a slice thickness of 4mm. Conclusion:Optimal parameters for DTI in the cervical spinal cord included a b-value of 900 seconds/mm2, 15 diffusion gradient directions, 5 excitations, and a slice thickness of 4mm.
Intelligent speech control system for human-robot interaction

Accurately extracting subjective contents of speech signals and applying it on controlling robots remain to this day a challenging task as well as an insistent demand in human-robot interaction (HRI). A simple classification of human's intentions may limit the development of robots' natural reactions to users. Additionally, there should be a control system that can understand and translate human's intentions into control inputs. This paper proposes an intelligent speech control system for HRI. The objective is to understand human' s speech commands via recognizing, quantifying audio signals and translating speech inputs into control inputs. Aiming at this purpose, three main parts for the system are designed: a speech recognition system, a speech measurement system and a control system. Specifically, Mel Frequency Cepstral Coefficient (MFCC) and Dynamic Time Warping (DTW) techniques are utilized to recognize isolate speech commands. An energy-based feature and novelly proposed spectrum-based features are introduced to represent subjective contents of speech signals followed by Random Forest (RF) as a regressor. Several control schemes are utilized to translate quantified speech signals into control inputs. Simulation results illustrate the performance of the proposed system and the robot adaptive control system outperforms other control methods on effectiveness and controllability. The improved spectrum-based features demonstrate the capacity to extract subjective information of signals.
Peroxiredoxin 1 Stimulates Secretion of Proinflammatory Cytokines by Binding to TLR4

Peroxiredoxin 1 (Prx1) is an antioxidant and molecular chaperone that can be secreted from tumor cells. Prx1 is overexpressed in many cancers, and elevation of Prx1 is associated with poor clinical outcome. In the current study, we demonstrate that incubation of Prx1 with thioglycollate-elicited murine macrophages or immature bone marrow-derived dendritic cells resulted in TLR4-dependent secretion of TNF-α and IL-6 and dendritic cell maturation. Optimal secretion of cytokines in response to Prx1 was dependent upon serum and required CD14 and MD2. Binding of Prx1 to thioglycollate macrophages occurred within minutes and resulted in TLR4 endocytosis. Prx1 interaction with TLR4 was independent of its peroxidase activity and appeared to be dependent on its chaperone activity and ability to form decamers. Cytokine expression occurred via the TLR-MyD88 signaling pathway, which resulted in nuclear translocation and activation of NF-κB. These findings suggest that Prx1 may act as danger signal similar to other TLR4-binding chaperone molecules such as HSP72.
Pleiotropic Effects of Obesity on Fracture Risk: The Study of Women's Health Across the Nation

Some aspects of an obese body habitus may protect against fracture risk (higher bone mineral density [BMD] and greater tissue padding), while others may augment that risk (greater impact forces during a fall). To examine these competing pathways, we analyzed data from a multisite, multiethnic cohort of 1924 women, premenopausal or early perimenopausal at baseline. Obesity was defined as baseline body mass index (BMI) > 30 kg/m2. Composite indices of femoral neck strength relative to fall impact forces were constructed from DXA‐derived bone size, BMD and body size. Incident fractures were ascertained annually during a median follow‐up of 9 years. In multivariable linear regression adjusted for covariates, higher BMI was associated with higher BMD but with lower composite strength indices, suggesting that although BMD increases with greater skeletal loading, the increase is not sufficient to compensate for the increase in fall impact forces. During the follow‐up, 201 women had fractures. In Cox proportional hazard analyses, obesity was associated with increased fracture hazard adjusted for BMD, consistent with greater fall impact forces in obese individuals. Adjusted for composite indices of femoral neck strength relative to fall impact forces, obesity was associated with decreased fracture hazard, consistent with a protective effect of soft tissue padding. Further adjustment for hip circumference, a surrogate marker of soft tissue padding, attenuated the obesity–fracture association. Our findings support that there are at least three major mechanisms by which obesity influences fracture risk: increased BMD in response to greater skeletal loading, increased impact forces, and greater absorption of impact forces by soft tissue padding. © 2014 American Society for Bone and Mineral Research.
Asymmetric Price Volatility Transmission between U.S. Biofuel, Corn, and Oil Markets

Linkages between agricultural commodity and energy prices have become more complex with increased ethanol production. The concern is whether the new corn–ethanol links lead to volatilityspillover transmission between food and energy prices. We investigate asymmetric volatility spillovers between oil, corn, and ethanol prices using a BEKK-multivariate-GARCH approach. Additionally, we use daily, weekly, and monthly futures prices to examine whether the use of different-frequency data leads to inconsistent results. The results support the existence of asymmetric volatility transmission between corn and ethanol prices. Furthermore, the volatilityspillover effects are different for the different-frequency prices, and positive and negative price changes generate inconsistent results.
HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery.

BACKGROUND The ability of hemoglobin based oxygen carrier-201 (HBOC-201) to safely reduce and/or eliminate perioperative transfusion was studied in orthopedic surgery patients. METHODS A randomized, single-blind, packed red blood cell (PRBC)-controlled, parallel-group multicenter study was conducted. Six hundred eighty-eight patients were randomized to treatment with HBOC-201 (H, n = 350) or PRBC (R, n = 338) at the first transfusion decision. Primary endpoints were transfusion avoidance and blinded assessment [Mann-Whitney estimator (MW)] of safety noninferiority. Groups were compared directly and by paired/matching group analyses predicated on a prospectively defined dichotomy [treatment success (HH) vs. failure (HR)] in the H arm and an equivalently defined dichotomy [</=3 (R3-) vs. >3 (R3+) units PRBC] in the R arm, based on need (moderate vs. high) for additional oxygen carrying capacity. RESULTS A total of 59.4% of patients in the H arm avoided PRBC transfusion. Adverse events (8.47 vs. 5.88), and serious adverse events (SAEs) (0.35 vs. 0.25) per patient were higher in the H versus R arms (p < 0.001 and p < 0.01) with MW = 0.561 (95 CI 0.528-0.594). HH versus R3- had identical (0.14) serious adverse events/patient and a MW = 0.519 (95% confidence limit 0.481-0.558), whereas the incidence was higher (0.63 vs. 0.47) for HR versus R3+ with a MW = 0.605 (95% confidence limit 0.550-0.662). Age (>80 years), volume overload and undertreatment contributed to this imbalance. CONCLUSION HBOC-201 eliminated transfusion in the majority of subjects. The between arms (H vs. R) safety analysis was unfavorable and likely related to patient age, volume overload, and undertreatment and was isolated to patients that could not be managed by HBOC-201 alone. However, patients <80 years old with moderate clinical need may safely avoid transfusion when treated with up to 10 units of HBOC-201.
Do Accruals Earnings Management Constraints and Intellectual Capital Efficiency Trigger Asymmetric Cost Behaviour? Evidence from Australia

This study examines whether accruals earnings management constraints and intellectual capital (IC) efficiency affect asymmetric cost behaviour by analysing data for the 1990 to 2016 period on firms listed on the Australian Securities Exchange. The analysis reveals that, on average, anti‐sticky cost behaviour occurs when firms have limited ability to engage in accrual earnings management to manipulate earnings in the current year. Further, IC efficiency – particularly human capital efficiency – increases the degree of cost stickiness. This study also finds that the degree of asymmetric cost behaviour is more pronounced in the post‐International Financial Reporting Standards (IFRS) period than in the pre‐IFRS period. The results suggest that the increased asymmetric cost behaviour in the post‐IFRS period derives from higher IC efficiency relative to the pre‐IFRS period. This study presents important implications for external stakeholders because they can consider the extent of earnings management constraints and the extent of firms’ IC efficiency as the determinants of asymmetric cost behaviour when assessing firms’ cost behaviour.
2,6-Diaminopyridinium tetraphenylborate–1,2-bis(5,7-dimethyl-1,8-naphthyridin-2-yl)diazene (1/1)

In the title compound, C5H8N3 +·C24H20B−·C20H18N6, the 1,2-bis(5,7-dimethyl-1,8-naphthyridin-2-yl)diazene molecule is essentially planar (r.m.s. deviation = 0.0045 Å) and aligned in nearly coplanar manner with the 2,6-diaminopyridinium ion, making a dihedral angle of 5.19 (5)°. The diaminopyridine molecule is protonated on the central pyridine N atom and the B atom bears the counter-charge. The amine groups of the diamino pyridinium cation form intramolecular N—H⋯N hydrogen bonds, resulting in linear and bent interactions with the naphthyridine ring system.
Elastic Fiber Assembly in the Adult Mouse Pubic Symphysis During Pregnancy and Postpartum1

ABSTRACT Impairment of pelvic organ support has been described in mice with genetic modifications of the proteins involved in elastogenesis, such as lysyl oxidase-like 1 (LOXL1) and fibulin 5. During pregnancy, elastic fiber-enriched pelvic tissues are modified to allow safe delivery. In addition, the mouse pubic symphysis is remodeled in a hormone-controlled process that entails the modification of the fibrocartilage into an interpubic ligament (IpL) and the relaxation of this ligament. After first parturition, recovery occurs to ensure pelvic tissue homeostasis. Because ligaments are the main supports of the pelvic organs, this study aimed to evaluate elastogenesis in the IpL during mouse pregnancy and postpartum. Accordingly, virgin, pregnant, and postpartum C57BL/6 mice were studied using light, confocal, and transmission electron microscopy as well as Western blots and real-time PCR. Female mice exhibited the separation of the pubic bones and the formation, relaxation, and postpartum recovery of the IpL. By the time the IpL was formed, the elastic fibers had increased in profile length and diameter, and they consisted of small conglomerates of amorphous material distributed among the bundles of microfibrils. Our analyses also indicated that elastin/tropoelastin, fibrillin 1, LOXL1/Loxl1, and fibulin 5 were spatially and temporally regulated, suggesting that these molecules may contribute to the synthesis of new elastic fibers during IpL development. Overall, this work revealed that adult elastogenesis may be important to assure the elasticity of the pelvic girdle during preparation for parturition and postpartum recovery. This finding may contribute to our understanding of pathological processes involving elastogenesis in the reproductive tract.
50 days of war on innocent civilian: Ma’an news agency coverage of Israeli and Palestinian conflict

Since the TV broadcasting was established in Arab countries until the 1990s, broadcasting during this specific time was based on a government control model, which derived from the view of broadcasting as an instrument of state advance that must be under the control from government. This kind of TVs, limits the broadcasting to highlight the government issue (1). In these kind of TVs, they focus with the leader’s opinion more than the Palestinian problem. By the way, the theme in Arab media determined to highlight the leader’s opinion who claims the right to speak on behalf of Palestinians. In September 1991, the first private TV in the Arab world was established when MBC went on the air from London. More private TVs followed after that like: Orbit in 1994 and ART in 1995, both based in Italy owned by Saudi businessmen, Future Television and LBC, both Lebanese based in Beirut, in 1995, and Al-Jazeera based in Qatar in 1996. In 2002 the number of the Arab TV stations was expanded to more than 150 TVS as government or privately owned, with capability of reaching the Arab people in any place in the world. This paper focuses on the media coverage of the conflict between two parties Palestine and Israel. The preview studies show that, in a conflict the media has an influential role and has responsibility for increasing violence or contributing to the resolution of conflict and mitigation of violence (2). This study examined 61 news coverage and framing of the Israel and Palestine conflict, known as the 50 days’ war from 8 July – 26 August 2014 by Ma’an News Agency, which delivers news to Ma’an TV (Palestinian satellite television station). A quantitative content analysis was employed to examine the news published during the war using five generic frames developed by (3). Holsti Inter-coder reliability and validity test value is 0.988 or 98% agreement. The results showed that conflict and human-interest frames were significantly visible compared to other frames in Ma’an news coverage. Portrayal of images of civilian killing, children and women killed in their homes and suffrage news coverage, in this war. Responsibility frame stressed on hospitals bombing and embargo of medications which reduced chances for Palestinian of immediate medical help. The economic frame highlighted the economic and financial losses of Palestinians as consequences of 50 days’ war. Most of them lost their income, businesses, agriculture land and homes and became refugees.
Psychomotor and cognitive effects of a single oral dose of talnetant (SB223412) in healthy volunteers compared with placebo or haloperidol

Central Nervous System (CNS) effects of talnetant, an NK-3 antagonist in development for schizophrenia, were compared to those of haloperidol and placebo. The study was randomised, double-blind, three-way crossover of talnetant 200 mg, haloperidol 3 mg or placebo. Twelve healthy males participated and EEG, saccadic and smooth pursuit eye movements, adaptive tracking, body sway, finger tapping, hormones, visual analogue scales (VAS) for alertness, mood and calmness and psychedelic effects, left/right distraction task, Tower of London and Visual and Verbal Learning Task were assessed. Haloperidol showed (difference to placebo; 95% CI; p-value) decreases in EEG α power (−0.87μV; −1.51/−0.22; p = 0.0110), saccadic inaccuracy (2.0%; 0.5/3.6; p = 0.0133), smooth pursuit eye movements (−7.5%; −12.0/−3.0; p = 0.0026), adaptive tracking (−3.5%; −5.4/−1.7; p = 0.0009), alertness (−6.8 mm; −11.1/−2.4; p = 0.0039), negative mood (−4.6 mm; −8.6/−0.6; p = 0.0266), the ability to control thoughts (1.2 mm; 0.2/2.3; p = 0.0214), and an increase of serum prolactin (ratio 4.1; 3.0/5.6; p < 0.0001). Talnetant showed decreased alpha power (−0.69 μV; −1.34/−0.04; p = 0.0390), improved adaptive tracking (1.9%; 0.1/3.7; p = 0.0370) and reduced calmness on VAS Bond and Lader (−4.5 mm; −8.0/−1.0; p = 0.0151). Haloperidol effects were predominantly CNS-depressant, while those of talnetant were slightly stimulatory. The results suggest that talnetant penetrates the brain, but it remains to be established whether this dose is sufficient and whether the observed effect profile is class-specific for NK3-antagonists.
Crowdfunding – the Interplay between Evolving Organization and Embedding Institutions

Abstract This paper explains the functioning of economic crowdfunding (equity- and loan-based). One of the angles from which crowdfunding can be analysed is institutional economics. Namely, it can be studied as a case where the spontaneous evolution of contractual forms is difficult and the need for legislative intervention arises. The paper explains the divergence of interests and risks of three groups of agents involved (platforms, fundraisers and funders). The radical asymmetry of power, to the advantage of the platform, is inherent in this type of business. The spontaneous development of strategies by the platforms (pricing and some non-price strategies relating to fundraisers) and recent developments in the direction of automatic decisions taken by the platform instead of funders, promotes the development of the crowdfunding business, but it does not ensure protection from risk of other parties. Still, the major source of risk for funders and partly also for fundraisers is the absence of liability of the platforms themselves. In these conditions, the spontaneous move towards the better alignment of the interests of parties seems unfeasible and external regulation is necessary.
Radical innovation in Marshallian industrial districts

ABSTRACT Radical innovation is under-researched in the geography of innovation. In this paper, the focus is on understanding how radical innovations occur in Marshallian industrial districts (MIDs), a phenomenon mostly overlooked. Using an exploratory and in-depth longitudinal case study methodology in two European MIDs, this paper analyzes radical innovation in MIDs and finds that the introduction of technology-distant knowledge and new firms from different (to the focal) industries are both necessary mechanisms, but not sufficient. Access to leading incumbents’ networks, based on social norms, becomes a crucial social factor necessary for radical innovation to occur in MIDs.
WRN Controls Formation of Extrachromosomal Telomeric Circles and Is Required for TRF2ΔB-Mediated Telomere Shortening

ABSTRACT Telomere dysfunction has been proposed to contribute to the pathogenesis of Werner syndrome (WS), a premature-aging disorder. The WS protein WRN binds TRF2, a telomere-specific factor that protects chromosome ends. TRF2 possesses an amino-terminal domain that plays an essential role in preventing telomere shortening, as expression of TRF2ΔB, which lacks this domain, leads to the formation of telomeric circles, telomere shortening, and cell senescence. Our data show that the TRF2ΔB-induced telomeric-loop homologous-recombination pathway requires WRN helicase. In addition, we show that WRN represses the formation of spontaneous telomeric circles, as demonstrated by the increased levels of telomeric circles observed in telomerase-positive WS fibroblasts. The mechanism of circle formation in WS cells does not involve XRCC3 function. Circle formation in WS cells is reduced by reconstitution with wild-type WRN but not mutant forms lacking either exonuclease or helicase activity, demonstrating that both enzymatic activities of WRN are required to suppress telomeric-circle formation in normal cells expressing telomerase reverse transcriptase. Thus, WRN has a key protective function at telomeres which influences telomere topology and inhibits accelerated attrition of telomeres.
Describing Parents' Perceptions, Valuation, and Support of Study Abroad Programs at Three Southern Land-Grant Universities

Parents are an integral part of the decision to study abroad, but little research investigates parents’ perceptions about study abroad. This study uses the Theory of Planned Behavior as a conceptual framework to explain perceptions and value of study abroad by parents of agriculture students Land-Grant universities based on previous international experiences and other beliefs. Researchers delivered a questionnaire to 1511 parents at three universities to measure perceptions and value of study abroad, and intent to support their students’ participation in study abroad. We found that parents had little international experience, which may limit their behavioral beliefs and impact their decision to support study abroad. We also found that parents believed short-term, summer programs, that cost between $2000 and $4000 were ideal. Finally, we found that parents believed that study abroad programs were somewhat important and that they were somewhat likely to support their students’ participation. Administrators and faculty should consider parent expectations and value when planning study abroad, and work to provide education and outreach to enhance value beliefs and normative beliefs of parents. Further research should explore the predictive value of previous experiences in parents’ likelihood to support a students’ decision to study abroad.