Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiple uses of basement membrane‐like matrix (BME/Matrigel) in vitro and in vivo with cancer cells

Significant advances in our understanding of cancer cell behavior, growth, and metastasis have been facilitated by studies using a basement membrane‐like extracellular matrix extract, also known as Matrigel. The basement membrane is a thin extracellular matrix that is found in normal tissues and contacts epithelial and endothelial cells, smooth muscle, fat, Schwann cells, etc. It is composed of mainly laminin‐111, collagen IV, heparan sulfate proteoglycan, entactin/nidogen, and various growth factors (fibroblast growth factor, transforming growth factor beta, epidermal growth factor, etc.). Most tumors of epithelial origin produce significant amounts of basement membrane matrix and interact with it particularly during metastasis. Cancer cells metastasize via degradation of the vessel basement membrane matrix to extravasate into the blood stream and colonize distant sites. This review will focus on the interaction of cancer cells and cancer stem cells with the basement membrane‐like matrix and the various uses of this interaction to accelerate tumor growth in vivo and to develop in vitro assays for invasion, morphology, and dormancy. Such assays and methods have advanced our understanding of the process of cancer progression, the genes and pathways that are involved, the potential of various therapeutic agents, the effects of neighboring cells, and the role of stem cells.
The coupling between spatial attention and other components of task-set: A task-switching investigation

Is spatial attention reconfigured independently of, or in tandem with, other task-set components when the task changes? We tracked the eyes of participants cued to perform one of three digit-classification tasks, each consistently associated with a distinct location. Previously we observed, on task switch trials, a substantial delay in orientation to the task-relevant location and tendency to fixate the location of the previously relevant task—“attentional inertia”. In the present experiments the cues specified (and instructions emphasized) the relevant location rather than the current task. In Experiment 1, with explicit spatial cues (arrows or spatial adverbs), the previously documented attentional handicaps all but disappeared, whilst the performance “switch cost” increased. Hence, attention can become decoupled from other aspects of task-set, but at a cost to the efficacy of task-set preparation. Experiment 2 used arbitrary single-letter cues with instructions and a training regime that encouraged participants to interpret the cue as indicating the relevant location rather than task. As in our previous experiments, and unlike in Experiment 1, we now observed clear switch-induced attentional delay and inertia, suggesting that the natural tendency is for spatial attention and task-set to be coupled and that only quasi-exogenous location cues decouple their reconfiguration.
Achieving consumers’ attention through emerging technologies: The linkage between e-marketing and consumers’ exploratory buying behavior tendencies

Purpose The purpose of this paper is to investigate the relationship between e-marketing (eM) and consumers’ buying behavior particularly exploratory buying behavior tendencies (EBBT) with moderating effect of a gender in the context of China. Design/methodology/approach Structural equation modeling using SPSS/AMOS was majorly applied to ascertain the relationship and hypotheses testing. First, the correlation of eM toward EBBT is examined using five factors: internet marketing (IM), e-mail marketing (EMa), intranet marketing (IMa), extranet marketing (EM), and mobile marketing (MM). Second, the relationship of each dimension of the eM model is determined autonomously to ensure the importance of such emerging technologies in marketing communications. Third, the effect of gender as a moderator is measured. To this end, primary data were collected through random distribution of the questionnaires among 1,600 consumers particularly students of the universities between February 2016 and August 2016 within North China. Findings The findings revealed that eM has a significant correlation on consumers’ EBBT. The comprehensive analysis of each factor of eM, i.e., IM, EMa, IMa, EM, and MM is positively correlated to EBBT. The present study revealed that gender did not moderate among the relationships of eM and EBBT. Additionally, study furnishes practical directions on how managers can utilize such emerging and revolutionary technologies in marketing activities to probe, understand, and reinforce consumers’ buying behavior. Research limitations/implications The research has limitations related to geographical location and sample size which thus limits the widespread generalization. Practical implications This study affirmed that organizations must engage the consumers using such technologies that are more likely acceptable by consumers in the present customer-oriented and digital era. The marketers must engage consumers the way they wish to be engaged by developing appropriate promotional strategies. The study provides possible implications both theoretical and managerial along with a contribution to the literature of eM and consumers’ buying behavior. Social implications Understanding the emerging technologies may furnish valuable insights for individuals to work well within Chinese SMEs. Originality/value The topic of eM has acknowledged as an evolving concept which is gaining an intense concern of both academician and practitioners. Therefore, more research mainly empirical work is still needed to probe the insights of eM across the globe. This study attempts to fulfill such need with empirical evidence together with an in-depth examination of eM determinants, collectively and autonomously.
Short-Term Associations Between Ambient Air Pollutants and Pediatric Asthma Emergency Department Visits

RATIONALE Certain outdoor air pollutants cause asthma exacerbations in children. To advance understanding of these relationships, further characterization of the dose-response and pollutant lag effects are needed, as are investigations of pollutant species beyond the commonly measured criteria pollutants. OBJECTIVES Investigate short-term associations between ambient air pollutant concentrations and emergency department visits for pediatric asthma. METHODS Daily counts of emergency department visits for asthma or wheeze among children aged 5 to 17 years were collected from 41 Metropolitan Atlanta hospitals during 1993-2004 (n = 91,386 visits). Ambient concentrations of gaseous pollutants and speciated particulate matter were available from stationary monitors during this time period. Rate ratios for the warm season (May to October) and cold season (November to April) were estimated using Poisson generalized linear models in the framework of a case-crossover analysis. MEASUREMENTS AND MAIN RESULTS Both ozone and primary pollutants from traffic sources were associated with emergency department visits for asthma or wheeze; evidence for independent effects of ozone and primary pollutants from traffic sources were observed in multipollutant models. These associations tended to be of the highest magnitude for concentrations on the day of the emergency department visit and were present at relatively low ambient concentrations. CONCLUSIONS Even at relatively low ambient concentrations, ozone and primary pollutants from traffic sources independently contributed to the burden of emergency department visits for pediatric asthma.
Human gingival fibroblast response to electropolished NiTi surfaces.

In the present study the in vitro biocompatibility of electropolished NiTi sheets is investigated. The assessment of cytotoxic effects due to potential Ni leaching from metal sheets was performed in direct contact with primary human fibroblast cultures using the 5-bromo-2'-deoxyuridine cell proliferation assay and morphologic studies via light microscopy and scanning electron microscopy. To assess toxic effects related to Ni-ions release, cells cultured in the presence of increasing concentrations of Ni(2+) (NiSO(4). 6H(2)O) served as positive controls. It is shown that while the addition of NiSO(4) caused severe proliferation decrease (approximately 80%) and morphologic damage at a concentration of 50 mg/L Ni(2+) no negative effects were observed in fibroblasts cultured in the presence of electropolished NiTi sheets. The results are discussed in terms of surface topography effects on the biocompatibility of NiTi shape memory alloys.
Glutamatergic neuronal projections from the marginal layer of the rostral ventral medulla to the respiratory centers in rats

The marginal layer (ML) that lines the ventral surface of the medulla oblongata (VMS) contains neurons thought to contribute to central chemoreception, the process by which systemic hypercapnia activates respiration. The transmitters and connectivity of ML neurons are poorly known. The present study focuses on a group of nonserotonergic ML neurons, often located in close proximity to the entry point of penetrating blood vessels. These neurons (∼300/brain) contain vesicular glutamate transporter2 (VGLUT2) mRNA and are thus probably glutamatergic. They cluster below the caudal half of the facial motor nucleus, lateral to the serotonergic cells of the ML. The projections of serotonergic and nonserotonergic ML neurons were investigated by retrograde labeling with Fluoro‐Gold. ML VGLUT2 mRNA‐expressing neurons lack spinal projections and innervate the dorsolateral pons and the ipsilateral ventral respiratory column (VRC), most particularly, the region of the pre‐Bötzinger complex and rVRG. The latter two regions receive a very small input from ML serotonergic neurons which, instead, heavily innervate the spinal cord. In conclusion, a small region of the VMS marginal layer contains glutamatergic neurons that innervate the main respiratory centers of the medulla oblongata and pons. These glutamatergic neurons are located in a chemosensitive region of the ML and their projections are consistent with a role in central chemoreception. The serotonergic neurons of the ML, though known to be activated by CO2, probably do not contribute to central chemoreception, given that they innervate sympathetic efferents and project at best very lightly to the VRC. J. Comp. Neurol. 473:73–85, 2004. © 2004 Wiley‐Liss, Inc.
The impact of non-timely 10-Q filings and audit firm size on audit fees

Purpose Prior studies suggest that non-timely 10-Q filings indicate higher potential risks than non-timely 10-K filings. Furthermore, larger audit firms tend to be more risk-averse and conservative about reporting. Inspired by these research streams, this paper aims to investigate the influence of non-timely 10-Q filings on audit fees and the impact of audit firm size on this association. Design/methodology/approach The cross-sectional audit fee regression model used in this study is similar to that used in prior audit fee research (Simunic, 1980; Francis et al., 2005; Hay et al., 2006; Wang et al., 2013). The model includes the following five major characteristics that would influence auditors’ fee decisions: auditee size (LNAT), complexity (REIVAT, FOREIGN, SEG), financial condition (LOSS, ROA, GROWTH, ZSCORE), special events (ICW, RESTATE, INITIAL, GC) and auditor type (BIG4). To examine the effect of non-timely 10-Q filings on audit fees, the variable NT10Q is included in the audit fee model. Findings The results indicate that when both non-timely 10-K and non-timely 10-Q filings are included in the regression model, only non-timely 10-Q filings are significantly associated with higher audit fees, suggesting that the presence of non-timely 10-Q filings signals more serious underlying problem than non-timely 10-K filings in the audit fees decision processes. In addition, we find that audit fees for firms audited by Big 4 auditors are 26.4 per cent higher when those firms file non-timely 10-Q reports, whereas there is no significant association between non-timely 10-Q filings and audit fees for firms audited by non-Big 4 auditors. Practical implications As no attention has been paid to the investigation of the impact of non-timely 10-Q filings on audit fees, with the aim of filling the gap of this specific research area, this study examines the association between non-timely 10-Q filings and audit fees and the influence of audit firm size on this association. Originality/value The contribution of this paper is threefold: first, it is the first study to examine the association between non-timely 10-Q filings and audit fees. The results show that non-timely 10-Q filings are a better and earlier indicator of audit risk than non-timely 10-K filings. Second, the results reveal that the relationship between non-timely 10-Q filings and audit fees is affected by audit firm size. Specifically, Big 4 auditors tend to charge higher audit fees in the presence of non-timely 10-Q filings, reflecting that they are more sensitive to audit risk than smaller audit firms are. Third, an examination of the quarterly effect of non-timely 10-Q filings on audit fees indicates a stronger effect from the first quarter’s non-timely 10-Q filings, compared to the second or third quarter.
Effective Professional Development in Agriscience Education: An Examination of Core Features

Reform efforts that are designed to increase student achievement often include in-service teacher professional development (PD) as a foundational component. However, the content and activities included in PD sessions varies greatly. Guided by Desimone’s (2009) Core Features of Professional Development, this study sought to describe agriscience teachers’ perceptions regarding various aspects of science integration based on their participation in PD. Participant responses to the survey instrument differed after attending the PD from what was reported prior to the event, supporting previous research regarding the effectiveness of PD on teacher behavior change. A comparison of the participant responses based on attending the PD prior to or following the restructuring of the PD or the number of times the respondent participated in the PD did not show practical differences, indicating that a PD’s repeated participation and the inclusion of active learning in PD were not directly influential in its effectiveness.
Collusion Attack on a Server-Aided Unbalanced RSA Key Generation Protocol

To generate the RSA keys efficiently on a low-power handheld device, Modadugu et al. proposed two RSA key generationprotocols. These protocols work with the help of the untrusted servers. Recently, Chen et al. proposed two improved protocols and claimed that their protocols are secure against the collusion attack. The one is a standard RSA key generation protocol and the other is an unbalanced version. This letter point out a weakness in Chen et al.'s unbalanced RSA key generation protocol. If the servers collude with each other they can derive the user's secret prime with high probability that enable the decryption of any ciphertext.
How to Improve Sustainable Competitive Advantage from the Distributor and the Supplier Networks: Evidence from the Paper-Making Industry in China

Confronted with urgent green requirements from customers and government, firms in high pollution and high resource-consuming industries must make changes and adopt green strategies as well as knowledge-management strategies to develop and sell green products to improve sustainable competitive advantage. To study how to leverage social networks to improve sustainable competitive advantage, our article sheds light on the effects of structural holes in the distributor network as well as in the supplier network and explores how mutual trust could moderate the impact of structural holes in both networks. Based on data from 122 matched pairs of suppliers and distributors of a high-pollution and high-resource-consuming industry, the Chinese paper-making industry, our empirical results demonstrate the positive effects of structural holes in the distributor and the supplier networks on the distributor sustainable competitive advantage. In addition, mutual trust could negatively moderate the relationship between structural holes in the distributor network and the distributor sustainable competitive advantage, but would positively moderate the relationship between structural holes in the supplier network and the distributor sustainable competitive advantage.
A Multilayer 2-D–2-D Coupled Model for Eddy Current Calculation in the Rotor of an Axial-Flux PM Machine

On the rotors of an axial-flux PM machine, NdFeB permanent magnets (PM) are very often placed because of their high energy density. As the NdFeB-magnets are good electric conductive, electric currents are induced in the magnets when they are exposed to a varying magnetic field. This varying magnetic field has two causes: variation of the airgap reluctance due to the effect of stator slots and armature reaction due to the stator currents. As axial-flux PM machines have an inherent 3-D-geometry, full 3-D-finite-element modeling seems necessary to calculate the eddy currents in the PM and to evaluate their corresponding losses. In this paper, however, the 1-D airgap magnetic fields of multiple multilayer 2-D finite-element simulations are combined to a 2-D airgap magnetic field using static simulations. In a subsequent step, this 2-D airgap magnetic field is imposed to a 2-D finite-element model of the PM to calculate the eddy currents and eddy current losses. The main benefit of this multilayer 2-D-2-D coupled model compared to 3-D finite-element modeling is the reduction in calculation time. Accuracy of the suggested multilayer 2-D-2-D coupled model is verified by simulations using a 3-D finite-element model.
Children with Autism Display more Social Behaviors after Repeated Imitation Sessions

Based on earlier studies, an adult’s imitations of the behaviors of children with autism lead to increased social behavior in the children. The present study explored the effects of repeated sessions of imitation. Twenty children were recruited from a school for children with autism to attend three sessions during which an adult either imitated all of the children’s behaviors or simply played with the child. During the second session the children in the imitation group spent a greater proportion of time showing distal social behaviors toward the adult including: (1) looking; (2) vocalizing; (3) smiling; and (4) engaging in reciprocal play. During the third session, the children in the imitation group spent a greater proportion of time showing proximal social behaviors toward the adult including: (1) being close to the adult; (2) sitting next to the adult; and (3) touching the adult. These data suggest the potential usefulness of adult imitative behavior as an early intervention.
Sum rules for metamaterials in parallel plate waveguides

An optical theorem and forward scattering approach for a bounded object confined between the plates of a parallel plate waveguide is investigated. A forward scattering sum rule together with the properties of positive real functions is used to show that the total absorption and scattering of an object is bounded by its static polarizability. A parallel plate waveguide and a parallel plate capacitor are used to estimate the dynamic and static properties, respectively. The results verify that the total cross section of an object integrated over the entire spectrum is proportional to the static polarizability.
Human Anti-CXCR4 Antibodies Undergo VH Replacement, Exhibit Functional V-Region Sulfation, and Define CXCR4 Antigenic Heterogeneity1

The chemokine receptor CXCR4 and its ligand stromal-derived factor-1 (SDF-1/CXCL12) are essential for many biological processes and various pathological conditions. However, the relationship between CXCR4 antigenic structure and SDF-1-mediated biological responses is poorly understood. In this report, a panel of human anti-CXCR4 Abs were isolated and used to explore CXCR4 antigenic heterogeneity and function. Multiple fixed CXCR4 antigenic isoforms were detected on the surface of hemopoietic cells. Epitope mapping studies demonstrated the complex nature of the surface-exposed CXCR4 epitopes. Ab-mediated inhibition of chemotaxis correlated strongly with binding affinity, epitope recognition, as well as the level of CXCR4 isoform expression. In addition, detailed genetic analyses of these Abs showed evidence of VH replacement. Importantly, structural and biochemical studies demonstrated tyrosine sulfation in novel regions of the V genes that contributed bidirectionally to the binding activity of the Abs. These data provide the first evidence that functional tyrosine sulfation occurs in self-reactive Abs and suggest a potential new mechanism that may contribute to the pathogenesis of Ab-mediated autoimmune disease. These Abs also provide valuable tools to explore the selective in vivo targeting of CXCR4 isoforms that may be preferentially expressed in certain disease states and involved in steady-state CXCR4-SDF-1 homeostasis.
Instrumental Teacher Education and the Incoming Tide of Information Technology: A Contemporary Guitar Perspective.

There is a metaphorical incoming tide of information technology (IT) in the global guitar community. This phenomenological study examines the activities of the online guitar community to determine its role in guitar pedagogy. It questions how the traditional teacher-student model can continue to operate amidst the floodwaters of online guitar education resources. An historical presentation, and analysis of current practice is offered, and the pedagogical value of some online resources are scrutinised. The process of enculturation through Contemporary Popular Music (CPM) education is discussed from the perspective of guitar pedagogy and the implications for instrumental guitar teaching are examined. This study was designed to examine the activities of the online guitar community to gain a perspective on the phenomenon for the purposes of informing teacher educators working with pre-service instrumental guitar teachers.
Forecasting electricity demand in Australian National Electricity Market

Load forecasting is a key task for the effective operation and planning of power systems. It is concerned with the prediction of hourly, daily, weekly, and annual values of the system demand and peak demand. Such forecasts are sometimes categorized as short-term, medium-term and long-term forecasts, depending on the time horizon. Long-term load forecasting is an integral process in scheduling the construction of new generation facilities and in the development of transmission and distribution systems, while short-term forecasting provides essential information for economic dispatch, unit commitment and electricity market. A comprehensive forecasting solution developed by Monash University is described in this paper. The semi-parametric additive models based forecasting system has been used to forecast the electricity demands for regions in the National Electricity Market. The forecasting system covers the time horizon from hours ahead up to years ahead, and provides both point forecasts (i.e., forecasts of the mean or median of the future demand distribution), and density forecasts (providing estimates of the full probability distributions of the possible future values of the demand). The performance of the methodology have been validated through the developments of the past years, and the forecasting system is currently used by the Australian Energy Market Operator (AEMO) for system planning and schedule.