Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of a T Cell Receptor Targeting an HLA-A*0201 Restricted Epitope from the Cancer-Testis Antigen SSX2 for Adoptive Immunotherapy of Cancer

The clinical success of adoptive immunotherapy of cancer relies on the selection of target antigens that are highly expressed in tumor cells but absent in essential normal tissues. A group of genes that encode the cancer/testis or cancer germline antigens have been proposed as ideal targets for immunotherapy due to their high expression in multiple cancer types and their restricted expression in immunoprivileged normal tissues. In the present work we report the isolation and characterization of human T cell receptors (TCRs) with specificity for synovial sarcoma X breakpoint 2 (SSX2), a cancer/testis antigen expressed in melanoma, prostate cancer, lymphoma, multiple myeloma and pancreatic cancer, among other tumors. We isolated seven HLA-A2 restricted T cell receptors from natural T cell clones derived from tumor-infiltrated lymph nodes of two SSX2-seropositive melanoma patients, and selected four TCRs for cloning into retroviral vectors. Peripheral blood lymphocytes (PBL) transduced with three of four SSX2 TCRs showed SSX241-49 (KASEKIFYV) peptide specific reactivity, tumor cell recognition and tetramer binding. One of these, TCR-5, exhibited tetramer binding in both CD4 and CD8 cells and was selected for further studies. Antigen-specific and HLA-A*0201-restricted interferon-γ release, cell lysis and lymphocyte proliferation was observed following culture of TCR engineered human PBL with relevant tumor cell lines. Codon optimization was found to increase TCR-5 expression in transduced T cells, and this construct has been selected for development of clinical grade viral vector producing cells. The tumor-specific pattern of expression of SSX2, along with the potent and selective activity of TCR-5, makes this TCR an attractive candidate for potential TCR gene therapy to treat multiple cancer histologies.
Location and Orientation Optimization for Spatially Stretched Tripole Arrays Based on Compressive Sensing

The design of sparse spatially stretched tripole arrays is an important but also challenging task and this paper proposes for the very first time efficient solutions to this problem. Unlike for the design of traditional sparse antenna arrays, the developed approaches optimize both the dipole locations and orientations. The novelty of the paper consists in formulating these optimization problems into a form that can be solved by the proposed compressive sensing and Bayesian compressive sensing based approaches. The performance of the developed approaches is validated and it is shown that accurate approximation of a reference response can be achieved with a 67 $\%$ reduction in the number of dipoles required as compared to an equivalent uniform spatially stretched tripole array, leading to a significant reduction in the cost associated with the resulting arrays.
Long-Term Clinical Outcomes After Everolimus- and Sirolimus-Eluting Coronary Stent Implantation: Final 3-Year Follow-Up of the Randomized Evaluation of Sirolimus-Eluting Versus Everolimus-Eluting Stent Trial

Background—Long-term clinical outcomes of everolimus-eluting stent (EES) compared with sirolimus-eluting stent (SES) have not been evaluated fully yet, especially whether EES implantation could positively affect late adverse events reported after SES implantation occurring >1 year. Methods and Results—In this all-comer prospective multicenter randomized open-label trial, 3196 patients were assigned randomly to implant either EES (n=1596) or SES (n=1600). At 3 years, EES was noninferior to SES on the primary safety end point (all-cause death or myocardial infarction; 10.1% versus 11.5%; noninferiority P <0.001; and superiority P=0.19). Cumulative incidence of definite stent thrombosis was low and was not significantly different between the 2 groups (0.5% versus 0.6%; P=0.81). There was no significant difference in the efficacy end point of target-lesion revascularization between the EES and SES groups (6.6% versus 7.9%; P=0.16). However, the cumulative incidence of target-lesion failure (cardiac death/target-vessel myocardial infarction/ischemia-driven target-lesion revascularization) was significantly lower in the EES group than in the SES group (8.8% versus 11.4%; P=0.01). By a landmark analysis at 1 year, the cumulative incidence of very late stent thrombosis and late target-lesion revascularization was not significantly different between the 2 groups (0.2% versus 0.2%; P=0.99 and 2.2% versus 2.9%; P=0.21, respectively). Conclusions—The efficacy and safety outcomes for this trial after EES implantation remained comparable with those after SES implantation through 3-year follow-up. However, improvement of clinical outcome after EES implantation compared with SES implantation was suggested by the significantly lower cumulative incidences of target-lesion failure, which has been the most widely used primary end point in the stent-versus-stent trials. Clinical Trial Registration—URL: http://www.clinicaltrials. gov. Unique identifier: NCT01035450.
Demonstration of KAPUER: A privacy policy manager on Android

In this demonstration, we present KAPUER, a system for managing users' privacy policies on Android. The system includes an authorization recommendation engine that learns user's preferences in terms of privacy and proposes him high level rules to protect his privacy from applications. Kapuer also provides a interface to manage all the rules it has created.
Nucleosides accelerate inflammatory osteolysis, acting as distinct innate immune activators

The innate immune system and its components play an important role in the pathogenesis of inflammatory bone destruction. Blockade of inflammatory cytokines does not completely arrest bone erosion, suggesting that other mediators also may be involved in osteolysis. Previously we showed that nucleosides promote osteoclastogenesis and bone‐resorption activity in the presence of receptor activator for nuclear factor κB ligand (RANKL) in vitro. The studies described here further demonstrate that selected nucleosides and nucleoside analogues accelerate bone destruction in mice immunized with collagen II alone (CII) but also further enhance bone erosion in mice immunized by collagen II plus complete Freund's adjuvant (CII + CFA). Abundant osteoclasts are accumulated in destructive joints. These data indicate that nucleosides act as innate immune activators distinct from CFA, synergistically accelerating osteoclast formation and inflammatory osteolysis. The potential roles of the surface triggering receptor expressed on myeloid cells (TREM) and the intracellular inflammasome in nucleoside‐enhanced osteoclastogenesis have been studied. These observations provide new insight into the pathogenesis and underlying mechanism of bone destruction in inflammatory autoimmune osteoarthritis. © 2011 American Society for Bone and Mineral Research
Differential Effect of p47phox and gp91phox Deficiency on the Course of Pneumococcal Meningitis

ABSTRACT Bacterial meningitis is a severe inflammatory disease of the central nervous system and is characterized by massive infiltration of granulocytes into the cerebrospinal fluid (CSF). To assess the role of NADPH oxidase-derived reactive oxygen species (ROS) in pneumococcal meningitis, mice deficient in either the gp91 subunit (essential for functioning of the phagocyte enzyme) or the p47 subunit (essential for functioning of homologous enzymes in nonphagocytic cells) were intracisternally infected with live Streptococcus pneumoniae, and defined disease parameters were measured during the acute stage of infection. While none of the parameters measured (including CSF bacterial titers) were significantly different in gp91−/− and wild-type mice, the infection in p47−/− mice was associated with significantly increased inflammation of the subarachnoid and ventricular space, disruption of the blood-brain barrier, and the presence of interleukin-1β, tumor necrosis factor alpha, and matrix metalloproteinase 9 in the cortex. These changes were associated with ∼10-fold-higher CSF bacterial titers in p47−/− mice than in wild-type mice (P < 0.001). In contrast to infection with live bacteria, the inflammatory response, including CSF leukocytosis, was significantly attenuated in p47−/− mice (but not gp91−/− mice) challenged with a fixed number of heat-inactivated pneumococci. Impairment of the host defense appeared to be responsible for the higher bacterial titers in p47−/− mice. Therefore, these results indicate that ROS generated by a gp91-independent NADPH oxidase(s) are important for establishing an adequate inflammatory response to pneumococcal CSF infection.
Exploring Second Language Writing Teacher Cognition

Second language (L2) teacher cognition has in recent years attracted the attention of an increasing number of researchers. While much L2 teacher cognition research focuses on the teaching of grammar (e.g. Phipps & Borg, 2009), L2 writing teacher cognition has received considerably less attention. It has, however, been suggested that L2 writing teachers’ perceptions of themselves as writers (Casanave, 2004) and as language learners may play a crucial role in their decision making as teachers of L2 writing. In an attempt to address this gap in the L2 teacher cognition literature, this study investigates English as a second language (ESL) writing teachers' beliefs about themselves as language learners and as writers in their first and/or second language(s). The purpose is to discover how ESL writing teachers’ beliefs about and practice of teaching L2 writing are influenced by their experiences in writing in their first and/ or second languages. Three native (NES) and two non-native English-speaking (NNES) teachers teaching L2 writing took part in the study. During a 15-week semester, their ESL writing classes were periodically observed and audio-recorded. Additionally, each teacher was interviewed two times using stimulated recall regarding both their classroom instructional practices and instruction provided in the margins of student papers. Findings revealed that, language learning in general was an important contributor to both NNES and NES teachers’ cognitions. Even NES teachers who were not advanced in their respective second and/or additional languages still referred to their language learning experiences. The NNES teacher participants also commented that they sometimes had to step out of their own language experience in order to better help their students. Results also indicated that L2 writing teachers without advanced L2 literacy skills were influenced primarily by their L1 writing experiences. L2 writing teachers with advanced L2 literacy skills, however, were greatly influenced by their L2 writing experience. In all of the cases, being an advanced writer, whether in their L1 or L2s, was an important contributor to L2 writing teachers’ cognitions. INDEX WORDS: Teaching writing, Teacher cognition, Second language (L2) writing teachers, Teaching practices, Second language teachers’ self-perceptions, Teachers’ writing experiences, Qualitative research, Teacher education EXPLORING SECOND LANGUAGE WRITING TEACHER COGNITION
Charm Physics - Like Botticelli in the Sistine Chapel

After sketching heavy quark expansions as applied to heavy flavour decays I emphasize the relevance of nonperturbative dynamics at the charm scale for exclusive $b\to c$ modes. I address the issue of quark-hadron duality for charm and discuss both the experimental and theoretical status of $D^0-\bar D^0$ oscillations. Finally I argue that comprehensive CP studies of charm decays provide novel portals to New Physics and suggest benchmark figures for desirable sensitivities.
Filterbank spectral estimators for the analysis of surface EMG signals during isometric contractions

The analysis of surface electromyogram (EMG) signals during voluntary isometric contractions can yield important information relating to muscle fatigue. These EMG signals are typically processed to extract specific variables such as the Mean Frequency (MNF) and the Median Frequency (MDF) and studies often follow how these parameters change through time. Traditional approaches to estimate the MNF and MDF variables are based on the periodogram, but this method suffers from a high degree of variability due in part the choice of window size, window function and other inherent limitations. In this paper we propose the use of data-adaptive filterbank spectral analysis techniques, namely the Power Spectrum Capon (PSC) and the Amplitude Spectrum Capon (ASC) methods. These new methods are shown to provide significant reductions in MNF and MDF parameter variability over a wide range of data window sizes.
New Journal of Physics Physical and geometrical properties of thermal plumes in turbulent Rayleigh – Bénard convection

We present a systematic experimental study of geometric and physical properties of thermal plumes in turbulent Rayleigh–Bénard convection using the thermochromic-liquid-crystal (TLC) technique. The experiments were performed in three water-filled cylindrical convection cells with aspect ratios 2, 1 and 0.5 and over the Rayleigh number range 5 × 107 6 Ra 6 1011. TLC thermal images of horizontal plane cuts at various depths below the top plate were acquired. Three-dimensional (3D) images of thermal plumes were then reconstructed from the 2D slices of the temperature field. The results show that the often-called sheetlike plumes are really 1D structures and may be called rodlike plumes. We find that the number densities for both sheetlike/rodlike and mushroomlike plumes have power-law dependence on Ra with scaling exponents of ∼0.3, which is close to that between the Nusselt number Nu and Ra. This result suggests that it is the plume number that primarily determines the scaling exponent of the Nu–Ra scaling relation. The evolution of the aspect ratio of sheetlike/rodlike plumes reveals that, as Ra increases, the plume geometry changes from more-elongated to less-elongated. Our study of the plume area fraction (fraction of coverage over the surface of the plate) further reveals that the increase in plume numbers with Ra mainly comes from an increase in plume emission, rather than fragmentation of plumes. In addition, the area, perimeter and shape complexity of the 2D horizontal cuts of sheetlike/rodlike plumes were studied and all are found to obey log-normal distributions. 3 Author to whom any correspondence should be addressed. New Journal of Physics 12 (2010) 075006 1367-2630/10/075006+22$30.00 © IOP Publishing Ltd and Deutsche Physikalische Gesellschaft
Active Learning for Top-K Rank Aggregation from Noisy Comparisons

We explore an active top-K ranking problem based on pairwise comparisons that are collected possibly in a sequential manner as per our design choice. We consider two settings: (1) top-K sorting in which the goal is to recover the top-K items in order out of n items; (2) top-K partitioning where only the set of top-K items is desired. Under a fairly general model which subsumes as special cases various models (e.g., Strong Stochastic Transitivity model, BTL model and uniform noise model), we characterize upper bounds on the sample size required for top-K sorting as well as for top-K partitioning. As a consequence, we demonstrate that active ranking can offer significant multiplicative gains in sample complexity over passive ranking. Depending on the underlying stochastic noise model, such gain varies from around logn log logn to n logn log logn . We also present an algorithm that is applicable to both settings.
Digital watermarking using reduced search fractal color image encoding

This paper presents a new binary stream information hiding method into compressed color image using reduced search fractal coding approach. The proposed method explores for each Range block a predefined search region around it in R, G and B planes to find the best Domain block. This encoding method reduces search time while preserve decoded image quality. The proposed watermarking method is based on relationships between Range and Domain blocks in R, G, B planes. Data extraction can be performed without the need of original host image and can be regarded as a blind approach. Experimental results show that our data embedding method has both high capacity and good transparency. However, this fragile method cannot resist typical attacks.
The Significance of Herpes Simplex for School Nurses

Herpes simplex is a common recurrent viral infection caused by the herpes simplex virus. The two closely related but distinct viruses that cause herpes simplex infections are herpes simplex 1 (HSV-1) and herpes simplex 2 (HSV-2). HSV-1 is commonly associated with infections around the oral mucosa and is the cause of herpes labialis, often referred to as a fever blister or cold sore. HSV-2 infections are usually acquired sexually. Genital herpes is a sexually transmitted disease with the highest prevalence among adolescents and young adults. Knowledge of viral activity, disease management, and community resources will assist the school nurse in developing and implementing strategies to prevent and manage this chronic disease.
Re-conceptualizing IS Strategic Alignment: the Translated Strategic Alignment Model (TSAM)

In this article, we propose a new conceptualization of strategic alignment leading to the proposal of a new model: the Translated Strategic Alignment Model (TSAM). We adopt a grounded theory approach, while studying three corporations. We then extend our research to other corporations through a Delphi method with five experts (IS consultants). The model of strategic alignment that we propose includes a three-level network involving the essential alignment of various stakeholders’ needs. We bring forward a new perspective on the fits traditionally studied in the literature and we propose seven fits whose “shores” 1 make sense to practitioners. In corporations TSAM may open a new path leading to the achievement of
Correlation of change size to fault-proneness: A real life case study

Continuous Integration (CI) is a common practice in agile software development processes. It improves the quality of the developed software and reduces the risk of integration problems. However, the effectiveness of CI depends heavily on the frequency of integration problems. For systematic improvement of the applied agile development process, the effect of large commits on the likelihood of integration problems is examined. Based on data gathered from the version control system and the CI-system of one large-scale, multi-site, agile-organized software development project in telecommunication industry, the size of commits is measured by three metrics: Count of Changed Lines, Count of Changed Files and the Count of Affected Components. As it can be found by this real life case study, there is a strong correlation between the size of a change and the likelihood of integration problems. In addition, the number of changed lines is only indirect correlated to the probability of integration problems.
Automatic WordNet Mapping Using Word Sense Disambiguation

This paper presents the automatic construction of a Korean WordNet from pre-existing lexical resources. A set of automatic WSD techniques is described for linking Korean words collected from a bilingual MRD to English WordNet synsets. We will show how individual linking provided by each WSD method is then combined to produce a Korean WordNet for nouns.
Fourth order method for Maxwell equations on a staggered mesh

We consider fourth order accurate compact schemes for numerical solutions to the Maxwell equations. We use the same mesh stencil as used in the standard Yee scheme. In particular extra information over a wider stencil is not required. Hence, it is relatively easy to modify an existing code based on the Yee algorithm to make it fourth order accurate. Also, a staggered mesh makes the boundary treatment easier. Finally, a staggered grid system gives a lower error than a non-staggered system.
Heart over mind: metabolic control of white adipose tissue and liver

Increasing evidence suggests that the heart controls the metabolism of peripheral organs. Olson and colleagues previously demonstrated that miR‐208a controls systemic energy homeostasis through the regulation of MED13 in cardiomyocytes (Grueter et al, ). In their follow‐up study in this issue of EMBO Molecular Medicine, white adipose tissue (WAT) and liver are identified as the physiological targets of cardiac MED13 signaling, most likely through cardiac‐derived circulating factors, which boost energy consumption by upregulating metabolic gene expression and increasing mitochondrial numbers (Baskin et al, ). In turn, increased energy expenditure in WAT and the liver confers leanness. These findings strengthen the evidence of metabolic crosstalk between the heart and peripheral tissues through cardiokines and also set the stage for the development of novel treatments for metabolic syndrome.
Contribuciones a la integración de subespacios desde una perspectiva biplot

EL TRABAJO SE ENMARCA DENTRO DE LOS ANALISIS BIPLOT, TIENE COMO OBJETIVO LA INTEGRACION DE RESULTADOS DE VARIOS ANALISIS BIPLOT Y LA BUSQUEDA DE LAS ESTRUCTURAS CONSENSO, TANTO PARA MARCADORES ESTANDAR COMO PARA MARCADORES PRINCIPALES. SE PROPONEN INDICES PARA VALORAR LA SIMILARIDAD ENTRE LOS SUBESPACIOS RESULTANTES Y PARA LA CUANTIFICACION DE LAS CONTRIBUCIONES DE LOS FACTORES CONSENSO A LOS DISTINTOS ELEMENTOS.
ABC of palliative care: Communication with patients, families, and other professionals

There is increasing awareness of the need for effective communication in health care, particularly with people who face a frightening diagnosis and an uncertain future for themselves or someone close to them. #### Communication problems when dealing with incurable and life threatening disease Recent research suggests that most patients wish to know their diagnosis and the progress of treatment and disease. This may conflict with health professionals' need to protect their patients and retain an optimistic message even when the outlook is very poor. Effective communication depends not only on the professionals but also on patients and carers. Language may be ambivalent, leading to genuine misunderstandings, and the needs of patients and carers do not always match. This may lead to health professionals feeling as though they are “pig in the middle” as they try to meet the needs of their patient and those of relatives. Recommended manner of breaking bad news When communicating with patients and relatives about incurable and life threatening disease, health professionals should remember to give attention to the environment and the physical comfort of all concerned. Standing in a corridor or a waiting room is unsatisfactory for everyone. Taking a patient or relative to a “quiet room” to discuss painful and difficult issues has the advantage of signalling the importance of the meeting and the fact that the news may be bad. Many patients, however, prefer to be in their own bed space, with the illusion of privacy given by drawn curtains. This is because the bed and surrounding space is the patient's territory, where he or she feels most in control. Bad news cannot be broken gently, but it can be given in a sensitive manner and at the individual's pace. Many patients are well aware of the seriousness of their situation, and this may be …