Miracle-dz/UniFAR-FTUs huggingface dataset:
A compact optical-microwave phase detector based on a polarization modulator

A compact optical-microwave phase detector is proposed and its performance is evaluated by synchronizing an 8-GHz oscillator to a 250-MHz mode-locked laser. The residual out-of-loop phase noise at 1 Hz and 100 kHz offset are −115 dBc/Hz and −146 dBc/Hz respectively. And the RMS timing jitter is 600 as when integrated from 100 kHz to 1 Hz. The proposed phase detector has a compact structure and is easy to implement using all commercial devices to achieve subfemtosecond synchronization between optical pulses and microwave oscillators.
Cooperation protocols for multimedia communication network based on ADIPS framework

The growth of both computer communication such as the Internet, and the computational power of computers makes multimedia applications possible for common use. However, some significant problems still remained unsolved, e.g., the efficient use of resources and the dynamic control of applications for satisfying the users' required QoS. To solve these problems, we propose an agent based approach to realize flexible multimedia communication based on the ADIPS Framework. We explain the cooperation protocols used in our flexible video conference system and also demonstrate the flexibility in terms of QoS control achieved by agent cooperation.
IN THE ABSENCE OF EPSTEIN‐BARR VIRUS INFECTION, PHORBOL ESTER MODULATES APOPTOSIS IN CYCLOHEXIMIDE‐TREATED BURKITT'S LYMPHOMA (BJA‐B) CELLS

We have shown previously that cycloheximide (CHX), a potent protein synthesis inhibitor, induces high levels of apoptosis in Epstein‐Barr virus free (EBV(−)) Burkitt’s lymphoma (BJA‐B) cells, with comparably reduced levels of apoptosis in the EBV positive (EBV(+)) cells. Modulation of CHX‐induced apoptosis in EBV(−) and (+) B cells is reported here using concurrent treatment with phorbol ester (phorbol 12,13‐dibutyrate, PdBu). Cells were collected at 0, 3, 6, 12, 24 and 48 hours after treatment with (i) 1 μg/ml CHX, (ii) 0.1 μg/ml PdBu (1 hour pretreatment before 0 h), or (iii) CHX + PdBu (CHX added at 0 h, 1 hour after PdBu). Control cultures were untreated. Apoptotic, necrotic or viable cells were quantified using histological, ultrastructural and biochemical parameters. Protein synthesis was assessed using 35S‐methionine incorporation. Intracellular calcium concentrations were measured using flow cytometry. PdBu alone had little effect on cell death. High levels of CHX‐induced apoptosis in EBV(−) cells were significantly reduced by concurrent addition of PdBu (P < 0.005). In contrast, low levels of CHX‐induced apoptosis in EBV(+) cells were not significantly altered by PdBu treatment. In EBV(−) cells, a negative relationship was observed between levels of apoptosis and calcium concentrations, whereas in EBV(+) cells, there was negligible correlation between these parameters. Thus high levels of CHX‐induced apoptosis in EBV(−) cells occur via a PKC‐dependent pathway, whereas CHX treatment of EBV(+) cells induces comparatively low levels of apoptosis that occur via a PKC‐independent mechanism. The results application in the therapeutic intervention for cancers developing in association with EBV infection.
Association of a Protective Monoclonal IgA with the O Antigen of Salmonella enterica Serovar Typhimurium Impacts Type 3 Secretion and Outer Membrane Integrity

ABSTRACT Invasion of intestinal epithelial cells by Salmonella enterica serovar Typhimurium is an energetically demanding process, involving the transfer of effector proteins from invading bacteria into host cells via a specialized organelle known as the Salmonella pathogenicity island 1 (SPI-1) type 3 secretion system (T3SS). By a mechanism that remains poorly understood, entry of S. Typhimurium into epithelial cells is inhibited by Sal4, a monoclonal, polymeric IgA antibody that binds an immunodominant epitope within the O-antigen (O-Ag) component of lipopolysaccharide. In this study, we investigated how the binding of Sal4 to the surface of S. Typhimurium influences T3SS activity, bacterial energetics, and outer membrane integrity. We found that Sal4 treatment impaired T3SS-mediated translocon formation and attenuated the delivery of tagged effector proteins into epithelial cells. Sal4 treatment coincided with a partial reduction in membrane energetics and intracellular ATP levels, possibly explaining the impairment in T3SS activity. Sal4's effects on bacterial secretion and energetics occurred concurrently with an increase in O-Ag levels in culture supernatants, alterations in outer membrane permeability, and changes in surface ultrastructure, as revealed by transmission electron microscopy and cryo-electron microscopy. We propose that Sal4, by virtue of its ability to bind and cross-link the O-Ag, induces a form of outer membrane stress that compromises the integrity of the S. Typhimurium cell envelope and temporarily renders the bacterium avirulent.
Ovarian Functions and Reproductive Preservation in Patients with Systemic Lupus Erythematosus: A Review of Literature

Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease of unknown etiology. The course of SLE is highly variable, with recurrent remission and exacerbation. The prevalence of the disease is affected by race, age and gender. In this review of literature, we tried to surf the web searching for all of articles concerned with ovarian functions, reserve and preservation among patients with SLE.
Pengaruh Bauran Pemasaran Terhadap Niat Menjadi Mitra Perspektif Islam Pada BMT Beringharjo Cabang Madiun

This study aims to analyze The Effect of Marketing Mix Towards Intention become Partner on Perspective of Islam at The Branch Office of BMT Beringharjo in Madiun. The tests carried out using multiple linear regression method, where the endogenous variable (Y) is a intention become partners and exogenous variables (X) is the marketing mix that is identified with product (X1), price (X2), place/distribution channel (X3), promotion (X4), people (X5), process (X6), physical evidence (X7), promise (X8), and patience (X9). In this study added two variables in the marketing mix of services in accordance with Islamic values that promise and patience. This study uses a quantitative approach. The characteristics of the population in this studi is a partner at The Branch Office of BMT Beringharjo in Madiun are actively engaged in transactions in 2014 and live in Madiun. Total sample of the respondents is 100 (one hundred). These samples were selected using nonprobability sampling with purposive sampling method with particular consideration. The results of this study indicate that simultaneous and partially, marketing mix variables consisting of product, price, place/distribution channel, promotion, people, process, physical evidence, promise, and patience shown the effect to intention become a partner on perspective of Islam at the branch office of BMT Beringharjo in Madiun. Variable place/distribution channel is the most dominant variable to the intention become partners on perspective of Islam at the branch office of BMT Beringharjo in Madiun. Suggestion for the branch office of BMT Beringharjo in Madiun should increase promotional activity to be more diverse so it can attract attention to prospective partners or partners who have joined, socialize product from BMT Beringharjo more clearly and detail, especially the difference with the product from conventional bank, and make a direct sales pitch way more exciting and creative by adding facilities and infrastructure in the promotion or by making a series of interesting activities and carried out in the crowd with direct sales activities.
Place and certification cue usage with Canadian forest products

Abstract Place-based promotion is used in many industries, including food and wine products, to create a competitive advantage. This study focused on consumer behaviours related to cue usage of origin (i.e. local and imported) and certification (i.e. sustainable products) with the goal of understanding the importance of these two cues used together or separately in the context of Canadian forest products. The study asked consumers in a small Canadian city about their quality beliefs, value assessments and purchase intentions for local and/or certified products. Using a quasi-experimental design, the manipulations include location (local vs. imported), certification (certified vs. uncertified) and product type (commodity vs. value-added). A repeated measures ANOVA found that both cues of origin and certification were important as respondents perceived local products as better quality and higher value, and respondents were more likely to purchase them over most other types. A regression analysis indicated that in most cases quality and value were predictors, but value was the most important indicator of the likeliness to purchase specific forest products. This study has the potential to aid marketers because certification cue usage does not appear to have been examined in conjunction with a product’s local vs. foreign origin.
Improvement of spiral MRI with the measured k‐space trajectory

The k‐space trajectory of a spiral imaging sequence was measured with a self‐encoding technique. The image quality improved dramatically when reconstructed with the measured k‐space trajectory. There were substantial artifacts in images reconstructed with the derived k‐space trajectory under the assumption of gradient system linearity. The results indicated the non‐linearity of the gradient system and the effectiveness of the correction technique.
Exploring the Growing Use of Technology in the Audit, with a Focus on Data Analytics

The SMP Committee (SMPC) is pleased to respond to the IAASB Data Analytics Working Group (DAWG) on the Request for Input, Exploring the Growing Use of Technology in the Audit, with a Focus on Data Analytics. The SMPC is charged with identifying and representing the needs of its constituents and, where applicable, to give consideration to relevant issues pertaining to small-and medium-sized entities (SMEs). The constituents of the SMPC are small-and medium-sized practices (SMPs) who provide accounting, assurance and business advisory services principally, but not exclusively, to clients who are SMEs. Members and Technical Advisers serving the SMPC are drawn from IFAC member bodies representing 22 countries from all regions of the world.
Explicit Compact Model for Ultranarrow Body FinFETs

An explicit charge-based compact model for lightly doped FinFETs is proposed. This design-oriented model is valid and continuous in all operating regimes (subthreshold, linear, and saturation) for channel lengths (L) down to 25 nm, Fin widths (W Si) down to 3 nm, and Fin heights (H Si) down to 50 nm with a single set of parameters. It takes short-channel effects, subthreshold slope degradation, drain-induced barrier lowering, drain saturation voltage with velocity saturation, channel length modulation, and quantum mechanical effects into account.
Whole‐Genome Analyses of Lung Function, Height and Smoking

A joint analysis of FEV1 (forced expiratory volume after one second) and height is reported using novel methodology, as well as a single‐trait analysis of smoking status. A first goal of the study was to incorporate dense genetic marker information in a random regression (Bayesian) model to quantify the relative contributions of genomic and environmental factors to the relationship between FEV1 and height. Smoking status was analysed using a probit random regression model and a second goal of the study was to estimate the genomic heritability of smoking status. Estimates of genomic heritabilities for height and FEV1 are equal to 0.47 and to 0.30, respectively. The estimates of the genomic and environmental correlations between height and FEV1 are 0.78 and 0.34, respectively. The posterior mean of the genomic heritability of smoking status is equal to 0.14 and provides evidence for the presence of genetic factors associated with the trait. Under the data augmentation strategy introduced, the joint posterior distribution of FEV1 and height factorises into two independent posterior distributions. This simplifies programming and results in excellent numerical behaviour. The approach can be readily extended for the joint analysis of an arbitrary number of traits. Details are shown in an Appendix.
Continuous and Efficient Lock Profiling for Java on Multicore Architectures. (Profilage continu et efficient de verrous pour Java pour les architectures multicœurs)

Today, the processing of large dataset is generally parallelised and performed on computers with many cores. However, locks can serialize the execution of these cores and hurt the latency and the processing throughput. Spotting theses lock contention issues in-vitro (i.e. during the development phase) is complex because it is difficult to reproduce a production environment, to create a realistic workload representative of the context of use of the software and to test every possible configuration of deployment where will be executed the software. This thesis introduces Free Lunch, a lock profiler that diagnoses phases of high lock contention due to locks in-vivo (i.e. during the operational phase). Free Lunch is designed around a new metric, the Critical Section Pressure (CSP), which aims to evaluate the impact of lock contention on overall thread progress. Free Lunch is integrated in Hotpost in order to minimize the overhead and regularly reports the CSP during the execution in order to detect temporary issues due to locks. Free Lunch is evaluated over 31 benchmarks from Dacapo 9.12, SpecJVM08 and SpecJBB2005, and over the Cassandra database. We were able to pinpoint the phases of lock contention in 6 applications for which some of these were not detected by existing profilers. With this information, we have improved the performance of Xalan by 15% just by rewriting one line of code and identified a phase of high lock contention in Cassandra during the replay of transactions after a crash of a node. Free Lunch has never degraded performance by more than 6%, which makes it suitable to be deployed continuously in an operational environment.
Multiple cellular and molecular mechanisms Are involved in human Aβ clearance by transplanted adult astrocytes

Astrocytes and microglia are able to degrade potentially neurotoxic β‐amyloid (Aβ) deposits typical for Alzheimer's disease (AD) pathology. Contrary to microglia, astrocytes degrade human Aβ from tissue sections in vitro without any additional stimulation, but it has remained unclear whether transplanted astrocytes are able to clear deposited human Aβ in vivo. We transplanted adult mouse astrocytes into the hippocampi of transgenic mice mimicking AD and observed their fate, effects on microglial responses, and Aβ clearance. After 2‐months follow‐up time, we discovered a significant reduction in Aβ burden compared with AD mice infused with PBS only. The remaining Aβ deposits were fragmented and most of the Aβ immunoreactivity was seen within the transplanted astrocytes. Concomitant to Aβ reduction, both CD68 and CD45 immunoreactivities were significantly upregulated but phagocytic microglia were often surrounding and engulfing Aβ burdened, TUNEL‐positive astrocytes rather than co‐localizing with Aβ alone. Astrocytes are known to degrade Aβ also by secreting proteases involved in Aβ catabolism. To study the contribution of neprilysin (NEP), angiotensin‐converting enzyme‐1 (ACE‐1), and endothelin‐converting enzyme‐2 (ECE‐2) in human Aβ clearance, we utilized an ex vivo assay to demonstrate that adult astrocytes respond to human Aβ by upregulating NEP expression. Further, incubation of adult astrocytes with known inhibitors of NEP, ACE‐1, or ECE‐2 significantly inhibited the removal of human Aβ from the tissue suggesting an important role for these proteases in Aβ clearance by adult astrocytes ex vivo. © 2011 Wiley‐Liss, Inc.
An Institution-Theoretic Approach to Unpacking Transactions Costs

Taking Coase as our impetus we discuss a tractable environment of transactions costs based on key institutional features that highlight the interaction between a polity and an economy in determining the rights over resources that are used in the production of goods. The setup allows us to consider that part of resources and goods that are a function of transaction costs, and which, in turn, vary by institutional features and regulatory behavior. First, we outline four friction costs that are analogous to Coase's transactions costs except that at the more fundamental level of the economy-cum-polity. Next we adumbrate the consequences of these costs on the economy, and how the structure of the institutional regime affects these costs and the implemented rights; in so doing, we construct metrics to evaluate institutional regimes. Lastly, we show how the institution-theoretic approach facilitates a different viewpoint to innovation and propose some possible extensions.
Intracellular and Extracellular ATP Coordinately Regulate the Inverse Correlation between Osteoclast Survival and Bone Resorption*

Background: Mature osteoclasts with a spontaneous tendency toward apoptosis resorb bone efficiently during their short lifespan. Results: Released ATP from intracellular stores has a negative impact on the bone resorption activity of osteoclasts by altering their cytoskeletal structures. Conclusion: ATP depletion leads to osteoclastic bone resorption. Significance: This study provides a new direction for investigating the mechanisms involved in physiological and pathological bone resorption. Osteoclasts, highly differentiated bone-resorbing cells of hematopoietic origin, have two conflicting tendencies: a lower capacity to survive and a higher capacity to execute energy-consuming activities such as bone resorption. Here, we report that when compared with their precursors, mature mitochondria-rich osteoclasts have lower levels of intracellular ATP, which is associated with receptor activator of nuclear factor κ-B ligand (RANKL)-induced Bcl-xL down-regulation. Severe ATP depletion, caused by disrupting mitochondrial transcription factor A (Tfam) gene, leads to increased bone-resorbing activity despite accelerated apoptosis. Although AMP-activated protein kinase (AMPK) activation by ATP depletion is not involved in the regulation of osteoclast function, the release of ATP from intracellular stores negatively regulates bone-resorbing activity through an autocrine/paracrine feedback loop by altering cytoskeletal structures. Furthermore, osteoclasts derived from aged mice exhibit reduced mitochondrial DNA (mtDNA) and intracellular ATP levels with increased bone-resorbing activity, implicating the possible involvement of age-related mitochondrial dysfunction in osteoporosis. Thus, our study provides evidence for a mechanism underlying the control of cellular functions by reciprocal changes in intracellular and extracellular ATP, which regulate the negative correlation between osteoclast survival and bone resorption.
tmRDB (tmRNA database)

Maintained at the University of Texas Health Science Center at Tyler, Texas, the tmRNA database (tmRDB) is accessible at the URL http://psyche.uthct. edu/dbs/tmRDB/tmRDB.html with mirror sites located at Auburn University, Auburn, Alabama (http://www.ag.auburn.edu/mirror/tmRDB/) and the Bioinformatics Research Center, Aarhus, Denmark (http://www.bioinf.au.dk/tmRDB/). The tmRDB collects and distributes information relevant to the study of tmRNA. In trans-translation, this molecule combines properties of tRNA and mRNA and binds several proteins to form the tmRNP. Related RNPs are likely to be functional in all bacteria. In this release of tmRDB, 186 new entries from 10 bacterial groups for a total of 274 tmRNA sequences have been added. Lists of the tmRNAs and the corresponding tmRNA-encoded tag-peptides are presented in alphabetical and phylogenetic order. The tmRNA sequences are aligned manually, assisted by computational tools, to determine base pairs supported by comparative sequence analysis. The tmRNA alignment, available in a variety of formats, provides the basis for the secondary and tertiary structure of each tmRNA molecule. Three-dimensional models of the tmRNAs and their associated proteins in PDB format give evidence for the recent progress that has been made in the understanding of tmRNP structure and function.
The role of cognitive biases and personality variables in subclinical delusional ideation

Introduction. A number of cognitive biases, most notably a data gathering bias characterised by “jumping to conclusions” (JTC), and the “bias against disconfirmatory evidence” (BADE), have been shown to be associated with delusions and subclinical delusional ideation. Certain personality variables, particularly “openness to experience”, are thought to be associated with schizotypy. Methods. Using structural equation modelling, we examined the association between two higher order subfactors (“aspects”) of “openness to experience” (labelled “openness” and “intellect”), these cognitive biases, and their relationship to subclinical delusional ideation in 121 healthy, nonpsychiatric controls. Results. Our results suggest that cognitive biases (specifically the data gathering bias and BADE) and the “openness” aspect are independently associated with subclinical delusional ideation, and the data gathering bias is weakly associated with “positive schizotypy”. “Intellect” is negatively associated with delusional ideation and might play a potential protective role. Conclusions. Cognitive biases and personality are likely to be independent risk factors for the development of delusions.
Complex dynamics of epileptic EEG

Electroencephalogram (EEG) - the recorded representation of electrical activity of the brain contain useful information about the state of the brain. Recent studies indicate that nonlinear methods can extract valuable information from neuronal dynamics. We compare the dynamical properties of EEG signals of healthy subjects with epileptic subjects using nonlinear time series analysis techniques. Chaotic invariants like correlation dimension (D/sub 2/) , largest Lyapunov exponent (/spl lambda//sub 1/), Hurst exponent (H) and Kolmogorov entropy (K) are used to characterize the signal. Our study showed clear differences in dynamical properties of brain electrical activity of the normal and epileptic subjects with a confidence level of more than 90%. Furthermore to support this claim fractal dimension (FD) analysis is performed. The results indicate reduction in value of FD for epileptic EEG indicating reduction in system complexity.
Overview of existing safeguarding techniques for automatically generated code

Code generators are increasingly used in an industrial context to translate graphical models into executable code. Since the code is often deployed in safety-related environments, the quality of the code generators is of paramount importance. In this paper, we will present and discuss state-of-the-art techniques for safeguarding automatic code generation applied in model-based development.