Miracle-dz/UniFAR-FTUs huggingface dataset:
Patterns of Transcription of Human Cytomegalovirus in Permissively Infected Cells

The rate of accumulation of cytomegalovirus transcripts in permissively infected human embryonic lung (HEL) cells was analyzed at various times after infection by hybridization of infected cell RNA to undigested or restriction endonuclease-digested cytomegalovirus DNA fixed to nitrocellulose filters. Differences in patterns of transcript accumulation were determined by measuring the abundance levels of RNA which hybridized to different HindIII-, XbaI-, or EcoRI-generated fragments of cytomegalovirus DNA. The results showed that a small but significant amount of cytomegalovirus RNA was detectable within the first 3 h after infection and that the rate of accumulation of these transcripts was static during the first 24 h, but increased thereafter. In general, the viral transcripts accumulating in infected cells could be divided into three classes. Immediate-early RNA (synthesized in the absence of protein synthesis in infected cells) hybridizes predominantly to a very restricted part of the genome and can be identified during the first 2 to 4 h postinfection. Early RNA (synthesized up to about 24 h after infection) originates from most regions of the genome but is characterized by the presence of transcripts which hybridize in great abundance to certain fragments. Late RNA (synthesized after 24 h, i.e., after the onset of viral DNA synthesis) hybridizes in approximately equal abundance to most regions of the viral genome. These results showed that a block in the transition from immediate-early to early RNA did not account for the extended period of time that elapses between the time of infection and the initiation of viral DNA synthesis. Interestingly, despite rapid adsorption and penetration and a static level of accumulation of transcripts in the cultures during the first 24 h, the number of cells that synthesized detectable amounts of viral antigens increased steadily during this time.
Changes in height and motor performance relative to peak height velocity: A mixed‐longitudinal study of Spanish boys and girls

Longitudinal changes in stature and motor performance were studied in an adolescent sample of 36 boys and 53 girls. Peak height velocity (PHV) was determined in 28 boys and 38 girls using non‐smoothed polynomials. The estimations of PHV and the age‐at—PHV are, respectively, 11.4 ± 2.2 cm/yr and 13.0 ± 0.63 years (boys), and 8.7 ± 1.6 cm/yr and 12.4 ± 0.57 years (girls). Performances in explosive strength (standing long jump; medicine ball throw) and flexibility (trunk maximal flexion) exhibit peak development during the year following PHV in both sexes. Maximal mean growth velocities in an endurance run (six minutes) occur before PHV in girls and after PHV in boys. Peak velocities in agility (4 × 6 m shuttle run), running speed (40 m dash) and abdominal strength‐resistance (sit‐ups for 30 seconds) occur before PHV in both sexes. There also is an acceleration of performances in these three tests after PHV. The results indicate that performance in several motor tests shows an adolescent spurt of an intensity that is proportionally comparable to the adolescent height spurt in both sexes. The dynamics of changes in motor performance in relation to PHV appears similar in both sexes. The most striking difference occurs in the endurance run. Am. J. Hum. Biol. 10:647–660, 1998. © 1998 Wiley‐Liss, Inc.
Fluid-attenuated inversion recovery vascular hyperintensity: an early predictor of clinical outcome in proximal middle cerebral artery occlusion.

BACKGROUND Few data are available on the relationship between fluid-attenuated inversion recovery vascular hyperintensities and proximal middle cerebral artery occlusion prognosis. OBJECTIVES To assess a fluid-attenuated inversion recovery vascular hyperintensities score (FVHS) and explore its relationship with recanalization status and clinical outcomes after intravenous thrombolysis. DESIGN Retrospective study. SETTING Stroke unit in a university hospital. PATIENTS Consecutive patients with proximal middle cerebral artery occlusion, thrombolysed within 6 hours, were selected from our prospective database. The FVHS (range,0-10; divided into low, medium, and high thirds) was quantified on the magnetic resonance image obtained at admission. Recanalization rates, infarction size (Alberta Stroke Program Early CT Score applied to diffusion weighted imaging [ASPECTS-DWI]), and 3-month functional outcomes (modified Rankin Scale score) were determined. Poor outcomes and large infarctions were defined as a modified Rankin Scale score higher than 2and an ASPECTS-DWI score of 5 or lower, respectively. MAIN OUTCOME MEASURES Interaction among FVHS,recanalization status, and outcomes. RESULTS Thirty-four patients had a low FVHS (4), 32 had a medium FVHS (5 or 6), and 39 had a high FVHS (≥7). The rate of poor functional outcome (modified Rankin Scale score >2) was higher for the group with low FVHSs than those with medium FVHSs and high FVHSs(82.3% vs 43.7% and 43.5%, respectively; P.001). Therate of 24-hour large infarctions(ASPECTS-DWI score 5)was higher for those with low FVHSs than those with medium and high FVHSs (88.2% vs 56.2% and 51.3%, respectively;P=.002). The recanalization rate was not associated with FVHS. Multivariate analysis retained low FVHS as an independent early predictor of poor clinical outcome (odds ratio=9.91; 95% CI, 2.01-48.93; P=.004)and large infarction (odds ratio=6.99; 95% CI, 1.78-27.46; P=.005). Low FVHS remained associated with poor outcomes regardless of recanalization status. Early recanalization in patients with a low FVHS decreased the poor functional outcome rate from 100% to 64.7% (P=.02). CONCLUSIONS The FVHS is an early independent prognostic marker for patients with proximal middle cerebral artery occlusion. Synergy between FVHS and recanalization status appears to be a critical determinant of final outcomes, supporting intensive reperfusion treatment for patients with a low FVHS.
tactoRing: A Skin-Drag Discrete Display

Smart rings are an emerging wearable technology particularly suitable for discrete notifications based on haptic cues. Previous work mostly focused on tactile actuators that stimulate only specific skin receptors on the finger, resulting in limited information expressiveness. We propose tactoRing, a novel tactile display that, by dragging a small tactor on the skin around the finger, excites multiple skin areas resulting in more accurate cue recognition. In this paper, we present the hardware and a perception study to understand the ability of users to recognize eight distinct points around the finger. Moreover, we show two different techniques to encode information through skin-dragging motion with accuracy up to 94%. We finally showcase a set of applications that, by combining sequences of tactile stimuli, achieve higher expressiveness than prior methods.
Lipid peroxidation and antioxidants status in human malignant and non-malignant thyroid tumours

Introduction: Thyroid epithelial cells produce moderate amounts of reactive oxygen species that are physiologically required for thyroid hormone synthesis. Nevertheless, when they are produced in excessive amounts, they may become toxic. Objective: The present study is aimed to compare the lipid peroxidation (LPO), antioxidant enzymes – superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-protein thiols (reduced glutathione (GSH)) in human thyroid tissues with malignant and non-malignant disorders. Design and Methods: The study used human thyroid tissues and blood samples from 157 women (147 diseased and 10 normal). Thyroid hormones, oxidative stress markers and antioxidants were estimated by standard methods. Results: LPO significantly increased in most of the papillary thyroid carcinoma (PTC: 82.9%) and follicular thyroid adenoma (FTA: 72.9%) tissues, whilst in a majority of nodular goitre (69.2%) and Hashimoto’s thyroiditis (HT: 73.7%) thyroid tissues, it remained unaltered. GSH increased in PTC (55.3%), remained unaltered in FTA (97.3%) and all other goiter samples studied. SOD increased in PTC (51.1%) and all other malignant thyroid tissues studied. CAT remained unaltered in PTC (95.7%), FTA (97.3%) and all other non-malignant samples (HT, MNG, TMNG) studied. GPx increased in PTC (63.8%), all other malignant thyroid tissues and remained unaltered in many of the FTA (91.9%) tissues and all other non-malignant samples (HT, MNG, TMNG) studied. Conclusions: In the case of non-malignant thyroid tumours, the oxidant–antioxidant balance was undisturbed, whilst in malignant tumours the balance was altered, and the change in r value observed in the LPO and SOD pairs between normal and PTC tissues and also in many pairs with multi-nodular goitre (MNG)/toxic MNG tissues may be used as a marker to differentiate/detect different malignant/non-malignant thyroid tumours.
Simulation analysis of III–V n-MOSFETs: Channel materials, Fermi level pinning and biaxial strain

In this work we employ a state-of-the-art Multi-Subband Monte Carlo simulator to investigate the performance of III-V n-MOSFETs with LG = 11.7nm. We analyze GaSb versus InGaAs strained and unstrained channel materials and the implications of Fermi level pinning on electrostatic and transport. We found that InGaAs MOSFETs can outperform strained silicon for low VDD applications. Advantages related to strained InGaAs are limited and mainly due to reduced Fermi Level Pinning.
The fyn art of N-methyl-D-aspartate receptor phosphorylation.

Glutamate is the major excitatory neurotransmitter in the mammalian brain. Glutamatergic synaptic transmission depends on postsynaptic ion channels (ionotropic glutamate receptors) that open in response to the binding of glutamate. Of the ionotropic glutamate receptors, the N-methyl-d-aspartate (NMDA) class has received particular attention because it plays a role not only in synaptic transmission but also in regulating synaptic plasticity. NMDA receptors are involved in activity-dependent remodeling of synapses during brain development (1). NMDA receptors also are required for a form of activity-dependent enhancement of synaptic transmission known as long-term potentiation (LTP), which has been intensively studied as a cellular correlate of memory formation in the brain (2). The regulation of NMDA receptor activity is thus of great significance for synaptic plasticity in both the developing and mature nervous system.
Calibrage Radiométrique en Utilisant des Collections de Photos

Mesurer l'irradiance emise par une scene est une caracteristique hautement souhaitable dans de nombreux algorithmes de vision par ordinateur. Des diverses applications comme, par exemple, l'estimation de la BRDF ou la realite augmentee necessitent des estimations des proprietes photometriques fiables. La methode la plus simple pour les obtenir est avec l'aide d'un appareil photo. Toutefois, un premier pas est necessaire pour atteindre cet objectif. Les valeurs d'intensites obtenues par un appareil photo doivent etre liees aux valeurs d'irradiance emises par l'objet. Ce phenomene est modele par une fonction non lineaire appelee la reponse radiometrique de la camera (CRF ou camera response function en anglais). Dans cet article, nous proposons d'exploiter la grande diversite des apparences d'un objet dans des collections de photos pour recuperer cette fonction non lineaire pour chacune des cameras en utilisant les images disponibles. Ce processus, egalement connu sous le nom de calibrage radiometrique, utilise un ensemble non structure d'images pour recuperer la position des cameras et un modele 3D de la scene. A partir de cette entree, la fonction de reponse de la camera est estimee pour chaque image. Ce probleme tres mal pose est uniquement traitable en se servant des a prioris appropries. L'approche proposee est basee sur un modele empirique pour parametrer la reponse radiometrique des cameras introduit par Grossberg et Nayar. Des methodes lineaires sont proposees. Ces approches permettent de calculer des solutions approximatives. Ensuite, des solutions plus exactes sont obtenues par des algorithmes d'optimisation non lineaire.
Applicability of anodic-stripping voltammetry and graphite furnace atomic-absorption spectrometry to the determination of antimony in biological matrices: a comparative study.

Both anodic-stripping voltammetry (ASV) and graphite furnace atomic-absorption spectrometry (ETA-AAS) were used to measure levels of antimony in biological samples such as whole blood, urine and mosquito larvae. Depending on the kind of sample or technique used, the sample treatment consisted of an acid digestion or simple dilution with water. In ASV determination, interferences from foreign ions (Cu, Fe and Zn) were studied. In ETA-AAS, different furnace programmes and different types of graphite tubes were tried. The calibrations were always performed both by running adequate antimony standards and by the standard additions method.
Doctors in the Wars

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Draft Genome Sequence of Xanthomonas axonopodis pv. allii Strain CFBP 6369

ABSTRACT We report here the draft genome sequence of Xanthomonas axonopodis pv. allii strain CFBP 6369, the causal agent of bacterial blight of onion. The draft genome has a size of 5,425,942 bp and a G+C content of 64.4%.
Characterization of the antibody isotype response in serum and milk of heifers vaccinated with a Staphylococcus aureus bacterin (LysiginTM)

The objective was to characterize the antibody isotype responses to vaccination with a commercial Staphylococcus aureus bacterin in dairy heifers. Twenty-five Holstein-Friesian dairy heifers were assigned at random to one of two groups, vaccinates (n=14) or controls (n=11). Vaccinates received two 5-ml doses of Lysigin 28 d apart in late gestation. Both groups were challenged with a heterologous serotype 5 strain of Staph. aureus by aseptic intramammary infusion on days 6, 7 and 8 of lactation. Samples for serum antibody isotype (IgG, IgG1, IgG2 and IgM) determinations were taken before each vaccination, immediately prior to challenge (6 d post-calving) and at the end of the study (28 d post-calving). Samples for milk antibody isotype determinations were taken immediately prior to challenge and at the end of the study. Antibody isotype sample-to-positive ratios (S[ratio ]P ratio=(mean test sample OD−mean within-plate negative control OD)/(mean within-plate positive control OD−mean within-plate negative control OD)) were determined in milk and serum using a series of ELISAs coated with different strains of Staph. aureus belonging to capsular polysaccharide (CP) serotype 5 or 8 or surface polysaccharide (SP) serotype 336. Vaccinates had higher mean serum IgG1 and IgG2 S[ratio ]P ratios than controls against all three strains of Staph. aureus (P[les ]0·023). Vaccinates had higher mean milk IgG S[ratio ]P ratios than controls against CP8 and SP336 strains of Staph. aureus (P[les ]0·030). Hence, a humoural immune response to the vaccine was detected in serum and milk, but responses varied according to strain and antibody isotype tested.
Axonal growth towards Xenopus skin in vitro is mediated by matrix metalloproteinase activity

We have previously demonstrated that the growth of peripheral nervous system axons is strongly attracted towards limb buds and skin explants in vitro. Here, we show that directed axonal growth towards skin explants of Xenopus laevis in matrigel is associated with expression of matrix metalloproteinase (MMP)‐18 and also other MMPs, and that this long‐range neurotropic activity is inhibited by the broad‐spectrum MMP inhibitors BB‐94 and GM6001. We also show that forced expression of MMP‐18 in COS‐7 cell aggregates enhances axonal growth from Xenopus dorsal root ganglia explants. Nidogen is the target of MMPs released by cultured skin in matrigel, whereas other components remain intact. Our results suggest a novel link between MMP activity and extracellular matrix breakdown in the control of axonal growth.
MPC algorithms for parallel multicell converters

The parallel association of classical commutation cells is a good solution for increasing the output current driven by the converters while the classical semiconductors technology are used. The control strategies used with this type of connection must be able to ensure good distribution of the output current among the different legs. This paper applies two control strategies based on the Model Predictive Control (MPC) in order to handle these type of connections. A comparison between these control strategies is also carried out by experiments.
Safety of Thrombolysis in Patients With Acute Ischemic Stroke and Cerebral Cavernous Malformations

Background and Purpose— Data on safety of intravenous thrombolysis with recombinant tissue-type plasminogen activator for acute ischemic stroke in patients with coexisting cerebral cavernous malformations (CCMs) are scarce. We assessed the risk of thrombolysis-associated hemorrhage in these patients. Methods— We searched our tertiary care hospital thrombolysis register for patients with CCM confirmed by MRI (3 T, Siemens, TimTrio) before thrombolysis for acute ischemic stroke. CCMs were graded into subtypes according to the Zabramski classification on the basis of their MRI appearance. The primary end point was symptomatic intracerebral hemorrhage according to European Cooperative Acute Stroke Study III (ECASS III) criteria. The secondary end point was any parenchymal hemorrhage. Results— In a total of 350 patients (median age, 76 years; interquartile range, 68–84; median National Institutes of Health Stroke Scale score, 8; interquartile range, 5–14; 51.4% women), CCMs were found in 9 patients (2.6%). Seven patients had a single CCM, and 2 patients had multiple CCMs with a total number of 12 CCMs in all patients. The subtype of CCMs was type III in 9 cases and type I in 3 cases. Symptomatic intracerebral hemorrhage occurred in 1 of 9 patients with CCM versus 11 of 341 patients without CCM (P=0.27). Parenchymal hemorrhage occurred in 2 of 9 patients with CCM versus 27 of 341 patients (P=0.17) without CCM. Conclusions— Given the limitations of our study (mainly low number of patients with CCM), the risk of thrombolysis-associated hemorrhage in patients with CCM remains uncertain. Although our data do not suggest an increased hazard from thrombolysis in patients with CCM, larger studies are necessary to determine definitively the influence of CCMs on parenchymal hemorrhage and symptomatic intracerebral hemorrhage.
Managing energy risk — A case study of Bulgaria with no nuclear power

This work investigates the impact of no license renewal for both reactors of Bulgaria's Kozloduy nuclear power plant. High spatial and temporal resolution power flow simulations for ten interconnected countries in central and southeastern Europe are conducted for 2016–2020. To account for new wind capacity, a novel approach that optimizes wind turbine placement in each new wind power plant and ranks the wind plants in terms of financial performance is used. It is shown that as the reactors are decommissioned, generation in Bulgaria shifts towards coal. CO2 emissions increase by 20% in 2020 compared to 2013. Electricity prices increase by 10% and 25%, respectively, with one and two reactors shutdown. Bulgaria changes from being a net exporter to an importer. Nevertheless, security of supply in terms of covering demand through imports is not compromised.
A study on automatic machine condition monitoring and fault diagnosis for bearing and unbalanced rotor faults

this paper demonstrates a simple and effective data-based scheme for the continuous automatic condition monitoring and diagnosis of bearing and unbalanced rotor faults. The key idea is to use a normalized cross-correlation sum operator as similarity measure for the automatic classification of machine faults using the k-nearest neighbor (k-NN) algorithm. This technique is both noise tolerance and shift-invariance. The experiments showed an error rate of 0.74% is achieved over a wide range of machine operating speed from 15Hz to 32Hz.
Pulmonary responses to purified zinc oxide fume.

BACKGROUND Metal fume fever is a flu-like illness caused by zinc oxide fume inhalation and mediated by unknown mechanisms. It is one of a group of work-related febrile inhalational syndromes. We studied bronchoalveolar lavage (BAL) obtained from cigarette smoking and nonsmoking human volunteers after controlled exposure to purified zinc oxide fume to explore the possible roles of proinflammatory cytokines in this condition. METHODS We studied 14 volunteers after inhalation exposure to purified zinc oxide fume and after sham exposure to air. The mean cumulative exposure was 537 +/- 232 mg min per cubic meter elemental zinc. Twenty hours after exposure we performed BAL. We analyzed BAL cells and studied BAL supernatant for cytokines including tumor necrosis factor-alpha (TNF alpha), interleukin(IL)-8, and IL-1 by enzyme-linked immunosorbant assay (ELISA). RESULTS Polymorphonuclear leukocytes (PMNs) were significantly increased in the BAL fluid obtained post-exposure compared to sham (mean difference = 41.3 +/- 16.8 x 10(3) per mL; p < 0.05). Cumulative zinc exposure positively correlated with exposure-sham differences in BAL supernatant concentrations of both TNF (r2 = 0.58; p = .002) and IL-8 (r2 = 0.44, p = 0.01). Exposure-sham concentration differences in BAL supernatant IL-8 and BAL PMNs were also positively correlated (r2 = 0.60; p < 0.001). Cigarette smoking was not associated with exposure-sham differences in BAL TNF or IL-8, but did demonstrate a packs-per-day dependent increase in BAL supernatant IL-1 (t = 2.3, p = 0.04) post-exposure compared to sham, after taking into account the zinc exposure response. CONCLUSIONS Purified zinc oxide fume inhalation causes an exposure-dependent increase in proinflammatory cytokines and PMNs in the lung. This supports a role for cytokine networking in mediating metal fume fever.