Miracle-dz/UniFAR-FTUs huggingface dataset:
Design of a low power UWB CMOS LNA for UWB system

Ultra Wideband (UWB) system has become an increasingly popular technology which is a wireless technology capable of transmitting data over the wide spectrum of frequency band with very low power and high data rates [1]. For a wideband application such as UWB system, wideband input matching and sufficient gain over the entire bandwidth are important. UWB systems are under development to satisfy such demands by adopting various advanced technologies. CMOS technology is one of the key technologies not only to provide high performance but also to reduce manufacturing cost. Low noise amplifier (LNA) is one of the most critical devices in the UWB receivers since the noise figure is a dominant figure of merit in the first stage of the receiver. In addition, it should have characteristics of low power consumption, low return loss and high gain over the entire frequency band of interest. In this paper, we propose a low power current reuse CMOS LNA to increase the transconductance of the LNA without increasing the power dissipation, unlike other technologies [2-4]. To reduce the power consumption and to achieve wideband gain performance, an inverter stage with current reuse technique is stacked on the top of a common source amplifier.
An improved de-embedding technique for on-wafer high-frequency characterization

An improved correction procedure for on-wafer S-parameter measurements has been developed and implemented. The method takes the effects of series parasitics into account in a simple, straightforward way. The improved performance of the method with respect to the usual method-which accounts for parallel parasitics only-especially at frequencies exceeding a few GHz is demonstrated. Its performance is compared with that of more complex methods. f/sub T/ determined from Y-parameters is not affected by this correction method, but the individual Y-parameters are. Therefore, for transistor characterization using measured Y-parameters the proposed correction should be adopted. <<ETX>>
A Nonisolated Multiinput Multioutput DC–DC Boost Converter for Electric Vehicle Applications

A new nonisolated multiinput multioutput dc-dc boost converter is proposed in this paper. This converter is applicable in hybridizing alternative energy sources in electric vehicles. In fact, by hybridization of energy sources, advantages of different sources are achievable. In this converter, the loads power can be flexibly distributed between input sources. Also, charging or discharging of energy storages by other input sources can be controlled properly. The proposed converter has several outputs with different voltage levels which makes it suitable for interfacing to multilevel inverters. Using of a multilevel inverter leads to reduction of voltage harmonics which, consequently, reduces torque ripple of electric motor in electric vehicles. Also, electric vehicles which using dc motor have at least two different dc voltage levels, one for ventilation system and cabin lightening and other for supplying electric motor. The proposed converter has just one inductor. Depending on charging and discharging states of the energy storage system (ESS), two different power operation modes are defined for the converter. In order to design the converter control system, small-signal model for each operation mode is extracted. The validity of the proposed converter and its control performance are verified by simulation and experimental results for different operation conditions.
Ubiquitin COOH-Terminal Hydrolase 1: A Biomarker of Renal Cell Carcinoma Associated with Enhanced Tumor Cell Proliferation and Migration[?Q1: Running head: UCHL1, a Biomarker of RCC. Short title OK?Q1]

Purpose: Renal cell carcinoma (RCC) accounts for 2% to 3% of all malignancies. It represents one of the most radiation- and chemotherapy-resistant tumors and surgical resections are only effective in organ-defined disease. However, RCC is an immunogenic tumor with response rates to immunotherapies between 10% and 20% of the treated patients. Due to the currently inefficient therapies and the low 5-year survival rates of RCC patients, novel diagnostic, prognostic, and therapeutic markers are urgently needed for this disease. Experimental Design: Proteome-based approaches were used to identify (a) differentially expressed proteins in RCC compared with normal kidney epithelium and (b) proteins that are able to induce an antibody response in RCC patients. Based on these experiments, a promising candidate was subsequently validated by reverse transcription-PCR, Western blot analyses, and immunohistochemistry. In addition, functional assays were done in generated transfectants. Results: The ubiquitin COOH-terminal hydrolase L1 (UCHL1) was found to be differentially expressed in both RCC lesions and RCC cell lines and immunoreactive using patients' sera. UCHL1 expression was often down-regulated in primary RCC when compared with normal kidney epithelium but dependent on the RCC subtype, the von Hippel-Lindau phenotype, and the tumor grading. Moreover, the frequency and the level of UCHL1 expression were higher in metastases when compared with primary RCC lesions. Gain-of-function transfectants exhibited a significant higher proliferation and migration rate than UCHL1-negative RCC cells. Conclusions: UCHL1 expression seems to be associated with the metastatic phenotype of RCC and therefore might serve as potential biomarker for the diagnosis and prognosis of RCC patients.
Stable Chloroplast Transformation of the Unicellular Red AlgaPorphyridium Species1

Red algae are extremely attractive for biotechnology because they synthesize accessory photosynthetic pigments (phycobilins and carotenoids), unsaturated fatty acids, and unique cell wall sulfated polysaccharides. We report a high-efficiency chloroplast transformation system for the unicellular red microalgaPorphyridium sp. This is the first genetic transformation system for Rhodophytes and is based on use of a mutant form of the gene encoding acetohydroxyacid synthase [AHAS(W492S)] as a dominant selectable marker. AHAS is the target enzyme of the herbicide sulfometuron methyl, which effectively inhibits growth of bacteria, fungi, plants, and algae. Biolistic transformation of synchronized Porphyridium sp. cells with the mutant AHAS(W492S) gene that confers herbicide resistance gave a high frequency of sulfomethuron methyl-resistant colonies. The mutant AHAS gene integrated into the chloroplast genome by homologous recombination. This system paves the way for expression of foreign genes in red algae and has important biotechnological implications.
Trapezoid Self-Scheduling: A Practical Scheduling Scheme for Parallel Compilers

A practical processor self-scheduling scheme, trapezoid self-scheduling, is proposed for arbitrary parallel nested loops in shared-memory multiprocessors. Generally, loops are the richest source of parallelism in parallel programs. To dynamically allocate loop iterations to processors, one may achieve load balancing among processors at the expense of run-time scheduling overhead. By linearly decreasing the chunk size at run time, the best tradeoff between the scheduling overhead and balanced workload can be obtained in the proposed trapezoid self-scheduling approach. Due to its simplicity and flexibility, this approach can be efficiently implemented in any parallel compiler. The small and predictable number of chores also allow efficient management of memory in a static fashion. The experiments conducted in a 96-node Butterfly GP-1000 clearly show the advantage of the trapezoid self-scheduling over other well-known self-scheduling approaches. >
Hepatotoxin microcystin-LR extraction optimization

Varios generos de cianobacterias produzem metabolitos secundarios toxicos, entre eles as hepatotoxinas microcistinas. A analise de microcistinas em aguas para abastecimento humano e uma exigencia do Ministerio da Saude (Portaria 518/2004), mas essa portaria ainda nao estabelece o metodo de extracao e analise a serem usados e a quantificacao da toxina e comumente realizada por ELISA ("enzyme-linked immunosorbent assay") ou HPLC (cromatografia liquida de alta eficiencia), cuja eficiencia depende do metodo de extracao utilizado. Neste trabalho foi desenvolvido um metodo simples, rapido e barato de extracao para o isolamento e identificacao de microcistinas. Para isso, selecionou-se a linhagem Microcystis aeruginosa NPLJ-4 descrita como produtora de microcistina-LR. Oito diferentes tratamentos foram testados para determinar a melhor extracao da toxina. As amostras foram analisadas por LC-MS (cromatografia liquida acoplada a espectrometria de massas), ELISA e Q-TOF ("quadrupole time-of-flight"). Os resultados mostraram que a melhor extracao foi a que usou sonicacao das amostras diluidas em agua. O metodo proposto permite o processamento rapido das amostras e estabelece um metodo de extracao para analise e identificacao de microcistina-LR e outras variantes.
Liquid nitrogen or phenolization for giant cell tumor of bone?: a comparative cohort study of various standard treatments at two tertiary referral centers.

BACKGROUND The rate of recurrence of giant cell tumor of bone is decreased by use of adjuvant treatments such as phenol, liquid nitrogen, or polymethylmethacrylate (PMMA) during curettage. We assessed recurrence and complication rates and functional outcome after curettage with use of phenol and PMMA, liquid nitrogen and PMMA, and liquid nitrogen and bone grafts. METHODS We retrospectively compared the relative effectiveness of treatment of giant cell tumors of bone at two tertiary centers with a regional function from 1990 to 2010. The 132 (of 201) patients who met the inclusion criteria had a mean age of thirty-three years (range, eleven to sixty-nine years). Treatment assignment depended purely on the center, with primary treatment consisting of curettage with use of phenol and PMMA (n = 82) at one center and with use of either liquid nitrogen and PMMA (n = 26) or liquid nitrogen and bone grafts (n = 24) at the other center. Recurrence and complication rates were determined, and functional outcome was assessed on the basis of the Musculoskeletal Tumor Society (MSTS) score. RESULTS The mean duration of follow-up was eight years (range, two to twenty-two years). Recurrence rates were comparable among the groups (28% for phenol and PMMA, 31% for liquid nitrogen and PMMA, and 38% for liquid nitrogen and bone grafts; p = 0.52). Soft-tissue extension increased the recurrence risk (hazard ratio [HR] = 2.1, 95% confidence interval [CI] = 1.1 to 4.0, p = 0.024). The complication rate was 33% after use of liquid nitrogen and bone grafts, 27% after liquid nitrogen and PMMA, and 11% after phenol and PMMA (p = 0.019); complications included osteoarthritis, infection, postoperative fracture, nonunion, transient nerve palsy, and PMMA leakage. The complication risk was increased by the presence of a pathologic fracture (HR = 4.1, 95% CI = 1.7 to 9.5, p = 0.001) and use of liquid nitrogen (HR = 3.9, 95% CI = 1.5 to 10, p = 0.006 for liquid nitrogen and bone grafts; HR = 3.1, 95% CI = 1.1 to 8.6, p = 0.028 for liquid nitrogen and PMMA). The mean MSTS score was 26 (range, 8 to 30) and was comparable among all three groups (p = 0.52). CONCLUSIONS Recurrence rates were comparable for treatment with phenol and PMMA, liquid nitrogen and PMMA, and liquid nitrogen and bone grafts. Complication rates were higher after use of liquid nitrogen. The functional outcome was excellent in all three cohorts.
Evaluating feature ranking methods in text classifiers

One of the major tasks in text categorization systems is dimensionality reduction, which strongly affects classification performance and scalability. Among dimensionality reduction methods, feature ranking-based feature selection, also known as best individual features, is scalable, simple, and inexpensive. However, selecting the proper feature ranking method for a given data set is not obvious without conducting experiments on the given data set. The performance varies depending on the data characteristics and the choice of the classifier. In this paper a framework, which is called feature meta-ranking, is introduced to identify the best feature ranking measure among a set of candidate solutions for a particular text classification problem. The feature meta-ranking technique is implemented based on the differential filter level performance method. This method uses a simple classifier, such as Rocchio, to estimate the behavior of the feature ranking measure with respect to a particular data set. With respect to the use of a classifier in the feature selection loop, the proposed method can be considered as a hybrid feature selection technique with minimal use of a classifier in the loop. The proposed method is evaluated by applying it to six data sets. Seven feature ranking measures are employed and evaluated. The stability of the method in terms of insensitivity to the resolution of filter level is demonstrated. The proposed method is also examined with more sophisticated classifiers such as support vector machines, and the results confirm the performance obtained with simple classifiers.
High accuracy navigation using laser range sensors in outdoor applications

This paper presents the design of a high accuracy outdoor navigation system based on standard dead reckoning sensors and laser range and bearing information. The data validation problem is addressed using laser intensity information. Beacon design aspect and location of landmarks are also discussed in relation to desired accuracy and required area of operation. The results are important for simultaneous localization and map building applications since the feature extraction and validation are resolved at the sensor level using laser intensity. This facilitates the use of additional natural landmarks to improve the accuracy of the localization algorithm. Experimental results in outdoor environments are also presented.
Palate Height: Another Indicator of Surgical Outcome in Unilateral Cleft Lip and Palate?

Objective: To determine whether palate height and maxillary arch depth are systematically related to the surgical center at which primary repair in unilateral cleft lip and palate (UCLP) was carried out. Design: A retrospective comparison based on study casts of consecutive cases of UCLP obtained at age 9 years from six different centers. The observer who conducted measurements was blinded to the source of individual records. Setting: The patients whose records were analyzed received all their surgical care in a national health service setting in six different northern European centers and regions. Patients: Patients were consecutively treated Caucasian children with non-syndromic complete UCLP born in the period 1976 to 1979. Main Outcome Measures: The main outcome measures for the original study were craniofacial form, dental arch relationships, nasolabial appearance, and speech. This report focuses on measurements of anterior maxillary arch depth and palate height. Results: Anterior arch depth and anterior palate height showed some variation among the centers. There was a tendency for anterior arch depth and palate height to also be reduced at centers at which patients showed unfavorable dental arch relationships. Conclusions: Anterior arch depth and palate height might be considered in future studies of surgical outcome and in their possible relationship to problems of articulation.
Culturally Responsive Instruction for English Language Learners With Learning Disabilities

This case study describes the culturally responsive instruction of one special education teacher with Latino English language learners (ELLs) with learning disabilities in an urban elementary school setting. This study was situated in a social constructivist research based framework. In investigating this instruction with ELLs, this study focused on how one teacher’s knowledge of culturally responsive pedagogy affected her special education instruction. Findings resulted in three major themes that were aligned with the current literature in this area: Cultural Aspects of Teaching Reading, Culturally Relevant Skills-Based Instruction, and Collaborative Agency Time. The results indicated that the success of special education with ELLs at the elementary education level might be dependent on how well the special education teacher integrates culturally responsive instruction with ELLs’ cultural and linguistic needs.
BILIARY TRACT COMPLICATIONS AFTER ORTHOTOPIC LIVER TRANSPLANTATION ENDOSCOPIC APPROACH TO DIAGNOSIS AND THERAPY

This study was undertaken to further define the role of endoscopic methods in the evaluation and treatment of biliary tract complications after liver transplantation and to determine the efficacy and safety of this approach. Fifty liver transplant patients were referred for endoscopic evaluation of a suspected biliary tract complication. Two patient groups were identified based on the indication for the endoscopic retrograde cholangiopancreatography (ERCP): Group 1 was suspected of having biliary fistula and group 2 was suspected of having bile duct obstruction. Group 1 consisted of 35 patients who developed bile peritonitis after inadvertent migration of the T-tube or intentional T-tube removal. Group 2 consisted of 15 patients who developed cholestatic hepatic chemistries in the absence of allograft rejection on liver biopsy. ERCP identified a biliary fistula at the T-tube insertion site into the bile duct in 32 (91%) group 1 patients. Twenty-six of 26 treated with a nasobiliary tube had fistula closure at a mean 5.2 days. Five of 6 treated with a stent, with or without sphincterotomy, had no leak at the time of stent removal (mean, 45 days). ERCP identified a cause for the cholestatic hepatic chemistries in 11 (73.5%) group 2 patients, including bile duct stones (n=4), anastomotic (n=3) or intrahepatic (n=2) strictures, bile duct necrosis (n=l), and hemobilia (n=l). Five of the 5 patients undergoing endoscopic therapy were treated successfully. The endoscopic complication rate was 4% and the 30-day mortality rate was 2%. During a mean follow-up of 15 months, 94% of the patients who were treated successfully had no recurrent biliary tract disease. The results of this study suggest that ERCP is an effective modality in the evaluation of patients with suspected biliary tract complications after liver transplantation. In selected patients, endoscopic therapy obviates the need for additional surgical or percutaneous intervention.
Bias Discovery in News Articles Using Word Vectors

Given the ongoing controversy over biased news, it would be useful to have a system that can detect the extent of bias in online news articles and indicate it to the user in real time. Here we measure bias in a given sentence or article as the word vector similarity with a corpus of biased words. We compute the word vector similarity of each of the sentences with the words taken from a Wikipedia Neutral Point of View (NPOV) corpus, measured using the word2vec tool, where our model is trained using Wikipedia articles. We then compute the bias score, which indicates how much that article uses biased words. This is implemented as a web browser extension, which queries an online server running our bias detection algorithm. Finally, we validate the accuracy of our bias detection by comparing bias rankings of a variety of articles from various sources. We get lower bias scores for Wikipedia articles than for news articles, which is lower than that for opinion articles.
Performance analysis of modified zero crossing counts method for heart arrhythmias detection and implementation in HDL

In this paper analysis shows that the performance of modified zero crossing count method for QRS complex detection with respect to traditional one. We test the performance for noisy and baseline shifted ECG record also. Furthermore simplicity and excellent performance of this method enhances its necessity to design in hardware level. We propose architecture for simple, portable, low cost QRS detector by implementing our modification in verilog HDL. The generated source has been simulated for validation and tested on software Verilogger Pro6.5. Signal data available from MIT-BIH Arrhythmia Database is collected to test proposed digital system by using test bench software. We have compared our device output with matlab output and calculate the percentage error is at about 0.09%.
Specific Interaction between Mycobacterium tuberculosis Lipoprotein‐derived Peptides and Target Cells Inhibits Mycobacterial Entry In Vitro

Tuberculosis (TB) continues being one of the diseases having the greatest mortality rates around the world, 8.7 million cases having been reported in 2011. An efficient vaccine against TB having a great impact on public health is an urgent need. Usually, selecting antigens for vaccines has been based on proteins having immunogenic properties for patients suffering TB and having had promising results in mice and non‐human primates. Our approach has been based on a functional approach involving the pathogen–host interaction in the search for antigens to be included in designing an efficient, minimal, subunit‐based anti‐TB vaccine. This means that Mycobacterium tuberculosis has mainly been involved in studies and that lipoproteins represent an important kind of protein on the cell envelope which can also contribute towards this pathogen's virulence. This study has assessed the expression of four lipoproteins from M. tuberculosis H37Rv, that is, Rv1411c (LprG), Rv1911c (LppC), Rv2270 (LppN) and Rv3763 (LpqH), and the possible biological activity of peptides derived from these. Five peptides were found for these proteins which had high specific binding to both alveolar A549 epithelial cells and U937 monocyte‐derived macrophages which were able to significantly inhibit mycobacterial entry to these cells in vitro.
Netherlands Twin Register: From Twins to Twin Families

Abstract In the late 1980s The Netherlands Twin Register (NTR) was established by recruiting young twins and multiples at birth and by approaching adolescent and young adult twins through city councils. The Adult NTR (ANTR) includes twins, their parents, siblings, spouses and their adult offspring. The number of participants in the ANTR who take part in survey and / or laboratory studies is over 22,000 subjects. A special group of participants consists of sisters who are mothers of twins. In the Young NTR (YNTR), data on more than 50,000 young twins have been collected. Currently we are extending the YNTR by including siblings of twins. Participants in YNTR and ANTR have been phenotyped every 2 to 3 years in longitudinal survey studies, since 1986 and 1991 for the YNTR and ANTR, respectively. The resulting large population-based datasets are used for genetic epidemiological studies and also, for example, to advance phenotyping through the development of new syndrome scales based on existing items from other inventories. New research developments further include brain imaging studies in selected and unselected groups, clinical assessment of psychopathology through interviews, and cross-referencing the NTR database to other national databases. A large biobank enterprise is ongoing in the ANTR in which blood and urine samples are collected for genotyping, expression analysis, and meta-bolomics studies. In this paper we give an update on the YNTR and ANTR phenotyping and on the ongoing ANTR biobank studies.