Miracle-dz/UniFAR-FTUs huggingface dataset:
Rat Rhabdomyosarcoma Cell Line Oncogene on Radiation Responses of a ras Influence of the H-Updated Version

Rat R2k rhabdomyosarcoma cells were transfected with the human li ras oncogene, which resulted in increased resistance to cell kill in vitro by a single dose of l37Cs 7-rays. A subline carrying one oncogene showed an increase in the quasi-threshold dose (/'.,) from 0.88 to 1.48 Gy. Another subline containing six oncogenes not only had an increased /), of 1.59 Gy but also showed an increase in the dose reducing cell survival to a fraction of e"' = 0.37 (Da) from 1.25 to 1.76 Gy. Analysis of the cell survival data according to the linear-quadratic formalism indicated that a decrease in the value of the coefficient of the linear component a is associated with a H-rai-mediated increase in radioresistance. In fractionated irradiation experiments it was observed that with a dose of 1 Gy/fraction a 1.8 times higher dose for an isoeffect of 10% cell survival (/Â»,â€ž) was needed for a subline with one I l-rav oncogene, while with fraction doses of 2 or 4 Gy only a 1.2 times higher I),,, was found. This indicates a more efficient repair of radiation-induced damage in the transfected subline. Tumors arising in the rat gastrocnemius muscle inoculated with cultured cells were irradiated with different doses of 300-kV \-rays. A single dose of 45 Gy was found to result in a 6% cure rate for the subline containing one H-ras oncogene and a 32% for the parental line. When a priming dose of 45 Gy was followed by fractionated irradiation with 1 Gy/fraction, an extra dose of 51 Gy would be needed to obtain a 75% cure rate for the transfected subline. An extra dose of only 10 Gy would be needed for the parental line. The percentage cure per unit of dose for the parental line irradiated with 1 Gy/fraction was estimated to be 4.3% -Gy~', whereas for the transfected tumor line it was 1.4%-Gy~'. This means that a 3.0 times higher cumulated absorbed dose would be needed for enhancing the cure rate from 32% to 75% in the subline with H-ras than for the parental line. With 2 Gy/fraction the difference in extra doses required for obtaining Â¡solevÃ©is of cure rates was found to be small, a factor of 1.4. The results indicate that in the course of fractionated irradiation with 1 Gy/fraction, in rivo repair is much more efficient in the transfected subline.
Corticotropin-Releasing Factor Receptors and Their Interacting Proteins: Functional Consequences

The corticotropin-releasing factor (CRF) system, which is involved in stress, addiction, and anxiety disorders such as depression, acts through G-protein–coupled receptors (GPCRs) known as type-1 and type-2 CRF receptors. The purpose of this review is to highlight recent advances in the interactions of CRF receptors with other GPCRs and non-GPCR proteins and their associated functional consequences. A better understanding of these interactions may generate new pharmacological alternatives for the treatment of addiction and stress-related disorders.
Determination of creatinine in serum and urine by cation-exchange high-pressure liquid chromatography.

We describe an HPLC method for quantifying creatinine, separating the analyte from other compounds in serum and urine by cation-exchange chromatography and measuring its absorbance at 234 nm. The precision of the method (CV) varied from 2.9% (mean creatinine concentration, 31 mumol/L) to 1.7% (361 mumol/L) within a series of assays and from 3.9% (34 mumol/L) to 2.4% (391 mumol/L) between series. A comparison with the Jaffé method, as performed with a Technicon SMA analyzer, gave the regression line yHPLC = 1. 00xJaffé - 12.0 (n = 141, r = 0.998, and Syx = 19). Results also are comparable with those of an enzymatic method, if the enzymatic method is standardized with a serum-based standard when serum samples are measured. An aqueous standard has to be used for enzymatic determination of creatinine in urine.
An Amharic speech corpus for large vocabulary continuous speech recognition

• has rich morphology -> many word forms. Phonetics Amharic has a set of 38 phones, seven vowels and thirty-one consonants. Consonants Manner Voicing Place of Articulation of Art/n Lab Dent Pal Vel Glo Stops Voiceless p[p] t[t] m[t∫ ] k[k] [? ] Voiced b[b] d[d] ¥[d ] g[g] GlottalizedI[p‘] μ[t‘] 1⁄2[t∫ ‘]q[q] Rounded [kw], [gw], [qw] Fricatives Voiceless f[f] s[s] ][∫ ] h[h] Voiced z[z] [ ] Glottalized O[s‘] Rounded [hw] Nasals Voiced m[m]n[n] }[ ] Liquids Voiced l[l], r[r] Semi vowelsVoiced w[w] y[j]
Spontaneous Brain Activity Relates to Autonomic Arousal

Although possible sources and functions of the resting-state networks (RSNs) of the brain have been proposed, most evidence relies on circular logic and reverse inference. We propose that autonomic arousal provides an objective index of psychophysiological states during rest that may also function as a driving source of the activity and connectivity of RSNs. Recording blood oxygenation level-dependent (BOLD) signal using functional magnetic resonance imaging and skin conductance simultaneously during rest in human subjects, we found that the spontaneous fluctuations of BOLD signals in key nodes of RSNs are associated with changes in nonspecific skin conductance response, a sensitive psychophysiological index of autonomic arousal. Our findings provide evidence of an important role for the autonomic nervous system to the spontaneous activity of the brain during “rest. ”
The Impact of Integrated Object Representations on Rejection Sensitivity

Despite robust findings identifying impairments in interpersonal functioning associated with rejection sensitivity (RS), the object representations (OR) of self in relation to others from which such rejection expectancies and anxieties arise have not been evaluated. Our study was the first effort to evaluate the structural aspects of object representations in RS, which may provide a crucial link in understanding why interpersonal distress may translate to rejection expectancies. Participants included 56 ethnically diverse undergraduate students who self-reported interpersonal distress and RS, and were assessed using the Social Cognition and Object Relation Scale. Results showed greater disparities in levels of integration in OR predicted greater RS. Furthermore, a moderation model was supported in which heightened interpersonal distress predicted higher levels of rejection sensitivity only for those with greater disparities in levels of OR integration. Thus, individuals with unstable OR integration may find it difficult to accurately attribute accepting or rejecting dispositions to others in distressing interpersonal contexts.
Hunting planets and observing disks with the JWST NIRCam coronagraph

The expected stable point spread function, wide field of view, and sensitivity of the NIRCam instrument on the James Webb Space Telescope (JWST) will allow a simple, classical Lyot coronagraph to detect warm Jovian-mass companions orbiting young stars within 150 pc as well as cool Jupiters around the nearest low-mass stars. The coronagraph can also be used to study protostellar and debris disks. At λ = 4.5 μm, where young planets are particularly bright relative to their stars, and at separations beyond ~0.5 arcseconds, the low space background gives JWST significant advantages over ground-based telescopes equipped with adaptive optics. We discuss the scientific capabilities of the NIRCam coronagraph, describe the technical features of the instrument, and present end-to-end simulations of coronagraphic observations of planets and circumstellar disks.
Development of a biped walking robot

This paper describes the mechanism of a biped walking robot. The biped robot consists of lower-limbs and a pelvis. Each leg has three segments such as a thigh, shank and sole that are connected through rotational joints each other. It has 12 degrees of freedom (DOF) such as two 2 DOF ankles, two 1 DOF knees and two 3 DOF hips. Its height is about 1.17 m, and its total weight is 43 kg. The movable angles of the biped robot are almost the same as a human. The actuator system of each axis consists of a motor, a timing belt, a harmonic drive gear, and two pulleys. This double speed reduction mechanism makes the biped robot have a high reduction ratio and sets the joint axis apart from the motor axis. Using the biped robot, various walking experiments are conducted and the effectiveness of the robot mechanism is confirmed.
WIDER Working Paper No . 2013 / 110 Trends and patterns of land use change and international aid in sub-Saharan Africa

The sub-Saharan Africa region recorded the fastest conversion of forest land to agriculture in the past 20 years. The region also has the widest yield gap and together with Latin America and Caribbean has the largest unused arable land. However, there are wide variations across countries and this offers valuable lessons on the drivers of agricultural intensification and land use dynamics. This study shows only few countries experienced a decrease in cropland extent. Additionally, few countries with low agricultural potential have shown higher actual maize yield while others with high potential have shown lower actual yield. Consistent with Boserupian theory, our analysis of the drivers of cropland extent show public expenditure on agricultural research and development and population density both have an inverted U non-linear relationship with cropland extent. Similarly, international aid first. /
On Baxter Q-operators for Toda Chain

We suggest the procedure of the construction of Baxter Q-operators for Toda chain . Apart from the one-paramitric family of Q-operators, considered in our recent paper (hep-th/9908179) we also give the construction of two basic Q-operators and the derivation of the functional relations for these operators. Also we have found the relation of the basic Q-operators with Bloch solutions of the quantum linear problem.
Face Recognition Using Incremental Principal Components Analysis

Human face recognition plays a significant role in security applications for access control and real time video surveillance systems, and robotics. Popular approaches for face recognition, such as principal components analysis (PCA), rely on static datasets where training is carried in a batch-mode on a pre-available image set. Real world applications require that the training set be dynamic of evolving nature where within the framework of continuous learning new training images are continuously added to the original set; this would trigger a costly frequent re-computation of the eigen space representation via repeating an entire batch-based training that includes the new images. Incremental PCA methods allow adding new images and updating the PCA representation, and offer the advantage of dispensing with the recently added images after model update. In this paper, various incremental PCA (IPCA) training and relearning strategies are proposed and applied to the candid covariance-free incremental principal component algorithm. The effect of the number of increments and size of the eigen vectors on the correct rate of recognition are studied. The results suggest that batch PCA is inferior to the four considered IPCA1-4, and that all IPCAs are practically equivalent with IPCA3 yielding slightly better results than the other IPCAs.
Approximate Reachability

We present a new SAT-based safety model checking framework, named approximate reachability (AR). AR is based on standard reachability analysis, but instead of maintaining a sequence of reachable state sets, AR maintains two sequences of (overand under-) approximate reachable state sets, checking safety and unsafety concurrently. AR is inspired by IC3/PDR, but it uses different refinement strategies. Specifically, AR uses standard Boolean-reasoning algorithms: one to find a satisfying cube of a satisfiable Boolean formula, and one to provide a minimal unsatisfiable core of an unsatisfiable Boolean formula. We applied AR to an amount of 548 hardware model-checking benchmarks, and compared its performance with IC3/PDR, a state-of-the-art SATbased model-checking technique. Our experimental results show that AR is able to solve 33 benchmarks that cannot be solved by IC3/PDR. We conclude that AR should be considered as a valuable member of any algorithmic portfolio for safety model checking.
A Comparison of Commercially Available Auditory Brainstem Response Stimuli at a Neurodiagnostic Intensity Level

iChirp-evoked auditory brainstem responses (ABRs) yield a larger wave V amplitude at low intensity levels than traditional broadband click stimuli, providing a reliable estimation of hearing sensitivity. However, advantages of iChirp stimulation at high intensity levels are unknown. We tested to see if high-intensity (i.e., 85 dBnHL) iChirp stimulation results in larger and more reliable ABR waveforms than click. Using the commercially available Intelligent Hearing System SmartEP platform, we recorded ABRs from 43 normal hearing young adults. We report that absolute peak latencies were more variable for iChirp and were ~3 ms longer: the latter of which is simply due to the temporal duration of the signal. Interpeak latencies were slightly shorter for iChirp and were most evident between waves I-V. Interestingly, click responses were easier to identify and peak-to-trough amplitudes for waves I, III and V were significantly larger than iChirp. These differences were not due to residual noise levels. We speculate that high intensity iChirp stimulation reduces neural synchrony and conclude that for retrocochlear evaluations, click stimuli should be used as the standard for ABR neurodiagnostic testing.
Using Computer-Based Virtual Tours to Assist Persons With Disabilities

Results of a recent study concerning computer technology and people with disabilities indicate that virtual reality tours are effective in conveying information and, in some cases, reducing anxiety. One hundred and ten subjects with physical disabilities participated in the study, and seven quantitative and qualitative instruments were used to assess study variables. Three physical locations were recreated virtually and include interactivity, captioning, digital audio and video, mapping, and other features. The implications may be valuable in both physical and virtual educational settings as educators strive to serve a growing student population.
Relational inductive shape analysis

Shape analyses are concerned with precise abstractions of the heap to capture detailed structural properties. To do so, they need to build and decompose summaries of disjoint memory regions. Unfortunately, many data structure invariants require relations be tracked across disjoint regions, such as intricate numerical data invariants or structural invariants concerning back and cross pointers. In this paper, we identify issues inherent to analyzing relational structures and design an abstract domain that is parameterized both by an abstract domain for pure data properties and by user-supplied specifications of the data structure invariants to check. Particularly, it supports hybrid invariants about shape and data and features a generic mechanism for materializing summaries at the beginning, middle, or end of inductive structures. Around this domain, we build a shape analysis whose interesting components include a pre-analysis on the user-supplied specifications that guides the abstract interpretation and a widening operator over the combined shape and data domain. We then demonstrate our techniques on the proof of preservation of the red-black tree invariants during insertion.
Distributed Target Localization and Tracking with Wireless Pyroelectric Sensor Networks

Abstract Due to the disadvantages of traditional localization & tracking at those aspects of users’ privacy protection, system configuration and maintenance, this paper proposes a new approach for infrared object localization and tracking with distributed wireless pyroelectric infrared sensors. A hierarchical architecture of visibility of Fresnel lens array is presented with spatial-modulated field of view (FOV). Firstly, the FOVs of Fresnel lens array in a sensor node are modulated to achieve a single degree of freedom (DOF) spatial partition; then the localization algorithm is proposed to coordinate multiple sensors nodes to achieve two DOF spatial partitions. To effectively solve the problem of WSN energy imbalance, a strategy of neighbor table multicast and an electoral method of the dynamic cluster head based on the biggest energy are presented in the distributed wireless sensor networks. The experiments show that the method proposed here has the advantages in high accuracy and strong anti-interference capability.
Performance study of common image steganography and steganalysis techniques

We investigate the performance of state of the art univer- sal steganalyzers proposed in the literature. These universal stega- nalyzers are tested against a number of well-known steganographic embedding techniques that operate in both the spatial and transform domains. Our experiments are performed using a large data set of JPEG images obtained by randomly crawling a set of publicly avail- able websites. The image data set is categorized with respect to size, quality, and texture to determine their potential impact on ste- ganalysis performance. To establish a comparative evaluation of techniques, undetectability results are obtained at various embed- ding rates. In addition to variation in cover image properties, our comparison also takes into consideration different message length definitions and computational complexity issues. Our results indi- cate that the performance of steganalysis techniques is affected by the JPEG quality factor, and JPEG recompression artifacts serve as a source of confusion for almost all steganalysis techniques. © 2006
Unconstrained face verification using fisher vectors computed from frontalized faces

We present an algorithm for unconstrained face verification using Fisher vectors computed from frontalized off-frontal gallery and probe faces. In the training phase, we use the Labeled Faces in the Wild (LFW) dataset to learn the Fisher vector encoding and the joint Bayesian metric. Given an image containing the query face, we perform face detection and landmark localization followed by frontalization to normalize the effect of pose. We further extract dense SIFT features which are then encoded using the Fisher vector learnt during the training phase. The similarity scores are then computed using the learnt joint Bayesian metric. CMC curves and FAR/TAR numbers calculated for a subset of the IARPA JANUS challenge dataset are presented.
Processing of Titanium Foams

Because of their excellent mechanical properties, low density and biocompatibility, titanium foams are attractive for structural and biomedical applications. This paper reviews current techniques for titanium foam processing, which are all based on powder‐metallurgy because of the extreme reactivity of liquid titanium. A first group of processes is based on powder sintering with or without place‐holder or scaffolds. A second group relies on expansion of pressurized pores created during prior powder densification.
The influence of ethical leadership to deviant workplace behavior mediated by ethical climate and organizational commitment

The purpose of this study is to analyze and explain the influence of ethical leadership, ethical climate and organizational commitment toward employee deviance in a workplace. ,This study was conducted in Malang Regency Government by using a sample of 120 respondents and Generalized Structured Component Analysis (GeSCA). ,From the study, it is found that ethical leadership could influence the formation of ethical climate in an organization which in turn will negatively affect the deviant behavior in the workplace. The results also indicate that the effect of ethical leadership is either direct or indirect toward the deviant behavior in the workplace. The indirect impact of this ethical leadership includes the sharpened perception of ethical climate which eventually will reduce the deviant behavior in the workplace. ,It is interesting that ethical leadership has no significant effect on organizational commitment but on ethical climate and in the end, it will influence the improvement of organizational commitment.
Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo

We have investigated the contribution of the tight junction (TJ) transmembrane protein junction-adhesion-molecule 1 (JAM-1) to trophectoderm epithelial differentiation in the mouse embryo. JAM-1-encoding mRNA is expressed early from the embryonic genome and is detectable as protein from the eight-cell stage. Immunofluorescence confocal analysis of staged embryos and synchronized cell clusters revealed JAM-1 recruitment to cell contact sites occurred predominantly during the first hour after division to the eight-cell stage, earlier than any other TJ protein analysed to date in this model and before E-cadherin adhesion and cell polarization. During embryo compaction later in the fourth cell cycle, JAM-1 localized transiently yet precisely to the apical microvillous pole, where protein kinase Cζ (PKCζ) and PKCδ are also found, indicating a role in cell surface reorganization and polarization. Subsequently, in morulae and blastocysts, JAM-1 is distributed ubiquitously at cell contact sites within the embryo but is concentrated within the trophectoderm apicolateral junctional complex, a pattern resembling that of E-cadherin and nectin-2. However, treatment of embryos with anti-JAM-1-neutralizing antibodies indicated that JAM-1 did not contribute to global embryo compaction and adhesion but rather regulated the timing of blastocoel cavity formation dependent upon establishment of the trophectoderm TJ paracellular seal.
Detecting new forms of network intrusion using genetic programming

How to find and detect novel or unknown network attacks is one of the most important objectives in current intrusion detection systems. In this paper, a rule evolution approach based on genetic programming (GP) for detecting novel attacks on network is presented and four genetic operators namely reproduction, mutation, crossover and dropping condition operators are used to evolve new rules. New rules are used to detect novel or known network attacks. A training and testing dataset proposed by DARPA is used to evolve and evaluate these new rules. The proof of concept implementation shows that the rule generated by GP has a low false positive rate (FPR), a low false negative rate (FNR) and a high rate of detecting unknown attacks. Moreover, the rule base composed of new rules has high detection rate (DR) with low false alarm rate (FAR).
When interoception helps to overcome negative feelings caused by social exclusion

Social exclusion affects mental and physical health. The ability to regulate emotional responses to social exclusion is therefore essential for our well-being. As individual differences in detecting bodily signals (interoceptive sensitivity, IS) have been associated with the ability of emotion regulation, we aimed at exploring whether IS fosters coping with social exclusion and flexibility in emotion regulation. The first study investigated subjective feelings and behavioral affiliation tendencies in response to ostracism using a cyberball paradigm. Sixty-nine participants were assessed who differed with respect to IS. The second study examined habitual emotion regulation processes focusing on suppression and reappraisal as well as IS in 116 participants. Main results were that the effect of ostracism on distress and behavioral affiliation tendencies were qualified by IS—being ostracized had less impact on participants with stronger IS. Furthermore, Study 2 revealed that IS was associated with habitually stronger emotion regulation strategies. We conclude that having access to bodily signals helps (IS) reducing aversive states provoked by social exclusion, probably due to the fact that IS is associated with emotion regulation strategies.