Miracle-dz/UniFAR-FTUs huggingface dataset:
Cargo Selection in Vesicular Transport: The Making and Breaking of a Coat

Intracellular traffic is mediated by vesicular/tubular carriers. The carriers are formed by the activity of cytosolic coat proteins that are recruited to their target membranes and deform these membranes into buds and vesicles. Specific interactions between recruited coat subunits and short peptide sequences (transport motifs) on cargo proteins direct the incorporation of cargo into budded vesicles. Here, we focus on cargo selection reactions mediated by COPII and AP‐2/clathrin vesicle coat complexes to explore common mechanisms by which coat assembly support localized and selective cargo sorting. Recent findings suggest that multiple, low‐affinity interactions are employed in a cooperative manner to support coat assembly and enable cargo recognition. Thus low‐binding affinities between coat subunits and transport motifs are transiently transformed into high‐avidity, multivalent and selective interactions at vesicle bud sites. The temporal and regulated nature of the interactions provide the key to cargo selection.
Cross-channel measurement and optimization: Targeting mobile app usage to increase desktop brand engagement

In this whitepaper we argue the fallacy of using mobile clicks for optimization or measurement of performance in mobile advertising. We provide evidence that the primary driver of mobile ad clicks is inventory hosting the ad, and that conditional on inventory, there is little correlation between CTR and the brand. Additionally, we propose an alternative methodology for targeting mobile impressions for an advertising campaign. We show that a particular user's mobile app usage is correlated with the brands the user interacts with online. We present a methodology for measuring the correlation between mobile app usage and online brand engagement and show results for two brands that Dstillery works with. We show that mobile app usage can accurately predict online brand engagements and we argue that this methodology presents a better targeting mechanism than CTR optimization. In order to target cross-device audiences we present an innovative bridge that maps users between mobile and desktop platforms. This bridge allows us to follow consumers from one domain to another and create a combined physical and digital behavioral profile that allows us to find the right users for each marketer with high precision
The Right Kind of Help? Tax Incentives for Staying Small

Some countries support smaller firms through tax incentives in an effort to stimulate job creation and startups, or alleviate specific distortions, such as financial constraints or high regulatory or tax compliance costs. In addition to fiscal costs, tax incentives that discriminate by firm size without specifically targeting R&D investment can create disincentives for firms to invest and grow, negatively affecting firm productivity and growth. This paper analyzes the relationship between size-related corporate income tax incentives and firm productivity and growth, controlling for other policy and firm-level factors, including product market regulation, financial constraints and innovation. Using firm level data from four European economies over 2001–13, we find evidence that size-related tax incentives that do not specifically target R&D investment can weigh on firm productivity and growth. These results suggest that when designing size-based tax incentives, it is important to address their potential disincentive effects, including by making them temporary and targeting young and innovative firms, and R&D investment explicitly.
Consumer adoption of m-banking: a behavioral reasoning theory perspective

Purpose The purpose of this paper is to examine the relative influence of “reasons for” and “reasons against” adoption of mobile banking (m-banking) among Indian consumers. Design/methodology/approach Using the framework of behavioral reasoning theory (BRT), hypothesized relationships between values, reasoning constructs, attitude and intentions were developed. The hypotheses were tested using a representative sample of data obtained from Indian banking consumers (n=379). Confirmatory factor analysis and structural equation modeling were used to analyze the data. Findings The findings indicate that both “reasons for” and “reasons against” have an influence on m-banking adoption. Among the “reasons for” m-banking adoption, ubiquitous is the major determinant, and among the “reasons against” m-banking adoption, tradition barrier is the major determinant. The findings also confirm that value of “openness to change” significantly influences reasons for adoption and has no impact on reasons against and attitude toward m-banking. Research limitations/implications This study examines customers in only one context (i.e. India). Future research can examine samples in other countries so that the results can be generalized. Also the mediating role of demographic factors can be studied in future studies to predict m-banking adoption. Practical implications The findings of this study emphasize the importance of examining both the pro-adoption and anti-adoption factors while developing marketing strategy. This study confirms that m-banking adoption can be increased if managers attempt to minimize the effect of barriers of m-banking adoption. Originality/value This is the first study to examine m-banking adoption using BRT, which investigates the reasons for and reasons against m-banking adoption in a single framework.
Vibrio sp. strain NM 10, isolated from the intestine of a Japanese coastal fish, has an inhibitory effect against Pasteurella piscicida

Vibrio sp. strain NM 10 with an inhibitory activity against Pasteurella piscicida K-III was isolated from the intestine of a spotnape ponyfish (Leiognathus nuchalis). This bacterium efficiently produced an antibacterial substance after growth at 20 degrees C for 24 h on 1/5 PYBG agar prepared with 50% seawater at pHs of 7.5 to 9.0. The antibacterial substance was heat labile and proteinaceous, with a molecular mass of less than 5 kDa, possibly a bacteriocin or a bacteriocin-like substance.
Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial.

PURPOSE To assess cardiac safety and potential cardiac risk factors associated with trastuzumab in the NCCTG N9831 Intergroup adjuvant breast cancer trial. PATIENTS AND METHODS Patients with HER2-positive operable breast cancer were randomly assigned to doxorubicin plus cyclophosphamide (AC) followed by either weekly paclitaxel (arm A); paclitaxel then trastuzumab (arm B); or paclitaxel plus trastuzumab then trastuzumab alone (arm C). Left ventricular ejection fraction (LVEF) was evaluated at registration and 3, 6, 9, and 18 to 21 months. RESULTS Of 2,992 patients completing AC, 5.0% had LVEF decreases disallowing trastuzumab (decrease below normal: 2.4%, decrease > 15%: 2.6%). There were 1,944 patients with satisfactory or no LVEF evaluation who proceeded to post-AC therapy. Cardiac events (congestive heart failure [CHF] or cardiac death [CD]): arm A, n = 3 (2 CHF, 1 CD); arm B, n = 19 (18 CHF, 1 CD); arm C, n = 19 (all CHF); 3-year cumulative incidence: 0.3%, 2.8%, and 3.3%, respectively. Cardiac function improved in most CHF cases following trastuzumab discontinuation and cardiac medication. Factors associated with increased risk of a cardiac event in arms B and C: older age (P < .003), prior/current antihypertensive agents (P = .005), and lower registration LVEF (P = .033). Incidence of asymptomatic LVEF decreases requiring holding trastuzumab was 8% to 10%; LVEF recovered and trastuzumab was restarted in approximately 50%. CONCLUSION The cumulative incidence of post-AC cardiac events at 3 years was higher in the trastuzumab-containing arms versus the control arm, but by less than 4%. Older age, lower registration LVEF, and antihypertensive medications are associated with increased risk of cardiac dysfunction in patients receiving trastuzumab following AC.
Approaches for Multi-Class Discriminant Analysis for Ranking Principal Components

—The problem of ranking features computed by principal component analysis (PCA) in N-class problems have been addressed by the multi-class discriminant principal component analysis (MDPCA) and the Fisher discriminability criterion (FDC). These methods are motivated by the fact that PCA components do not necessarily represent important discriminant directions to separate sample groups. Given a database, the MDPCA builds a linear support vector machine (SVM) ensemble to get the separating hyperplanes that are combined through an AdaBoost technique to determine the discriminant contribution of each PCA feature. The FDC technique sorts PCA components according to the ratio of the between-class scatter over the within-class scatter. In this paper, we review these techniques and compare their performance in facial expression experiments. The classiﬁcation results have shown the beneﬁts of sorting principal components using FDC and the MDPCA though both methodologies are not so efﬁcient when compared with PCA for reconstruction tasks.
Intake, digestion, passage rate and serum prolactin in growing dairy steers fed endophyte-infected fescue with noninfected fescue, clover or wheat straw.

Growing Holstein steers were used in two Latin-square experiments to determine the effects of supplementation of endophyte-infected fescue hay diets with other forages on intake, digestion, passage rate and serum prolactin concentration. In Exp. 1, five steers (average weight of 186 kg) were fed ad libitum amounts of endophyte-infected and noninfected fescue hays (I and NI, respectively) of similar quality in 0:1, 1:3, 1:1, 3:1 and 1:0 proportions. Total dry matter (DM) intake as a percentage of body weight (BW) linearly decreased . 0055% for each 1% increase in dietary I (P less than .05). Dry matter intakes with 100% I and 100% NI diets were 2.13 and 2.72% of BW, respectively. Total tract digestion of neutral detergent fiber (NDF) increased linearly (P less than .05) with increasing I (66.0, 65.9, 66.3, 68.1 and 69.6%). Ruminal passage rate of particulates changed linearly (P less than .05) and quadratically (P less than .10) as I in the diet increased (3.5, 3.4, 2.6, 2.8 and 2.8%/h), while serum prolactin concentration and rectal temperature decreased linearly (P less than .05). In Exp. 2, four steers (average weight of 137 kg) were given ad libitum amounts of wheat straw (WS) or . 73% of BW of clover hay (C) at 0800 and free access to either I or NI at 1600. Total intake as a percentage of BW was greatest for C with NI (3.04), intermediate for WS with NI (2.70) and lowest for C with I (2.30) and WS with I (2.23; P less than .05). Fescue intake (percentage of BW) was lowest (P less than .05) for C with I (1.56) and higher (P less than .05) for WS with NI (2.63) than WS with I (2.12); fescue intake for C with NI (2.33) was intermediate (P greater than .10) to WS with NI and WS with I. The results are interpreted to indicate that increasing the dietary level of I depressed intake linearly and markedly. Intake of diets high in I appears to be lower than can be explained only by ruminal-fill factors. When animals that are consuming basal I diets are provided access to nontoxic, high-quality forage, changes in intake may differ from those with basal diets of nontoxic forage.
"Hr as Strategic Partner: Manpower- Engines of Change in Health Sector Reforms and Human Resource"

Turnaround in healthcare strategy and human resource strategy knowledge insight aims to address expertise and insight about market overviews and management issues for top level management executives. Attempts are to be made to identify problems and propose solutions by referring to the fields of organisational operation and human resources development from various perspectives. The functions and performance of personnel are focussed on in terms of management resources. Complicated and advanced skills are required as per the careful selection of employees’ desired functions. It is necessary to approach the healthcare strategies and human resources strategies essential for business management from a comprehensive perspective including both human nature and sociality. There is to some governance reform which focuses on managerial human resources.
Evaluation Of Effect Of Trace Elements And Antioxidants Levels In Patient With Ischaemic Heart Disease

Cardiovascular Disease, one of the chronic, non-communicable diseases, has become a major public health problem in many developing countries. Of the CVD, ischaemic heart disease is the predominant entity contributing to mortality and morbidity. Therefore, rapid diagnosis and treatment as well as assessment of the prognosis are very essential and challenging in ischaemic heart disease. Oxidative stress is implicated in the etio pathogenesis of ischaemic heart disease. Measurement of lipid peroxidation is of value in estimating oxidative stress. Therefore, the aim of this study was 1) To assess oxidative stress by determination of MDA as a lipid peroxidation marker in ischaemic heart disease and controls. 2) To measure trace elements iron, copper and zinc 3) To assess antioxidants enzymes i. e. erythrocyte superoxide dismutase and erythrocyte catalase levels have been determined in 30 patients with ischaemic heart disease & 30 controls. We observed that significantly increased levels of serum iron (P< 0. 001), copper (P<0. 001) and lipid peroxidation (P<0. 001) whereas the levels of serum zinc and activities ofenzymes like erythrocyte SOD and catalase were significantly decreased (P<0. 001) in ischaemic heart disease as compared to controls. Iron /zinc ratio, copper/zinc ratio were elevated in IHD patients. Significantly positive correlation was observed between MDA and iron as well as MDA and copper levels. Negative correlation between MDA & zinc levels was found. This study indicated that the antioxidant status of IHD patients was low; suggesting the role of free radical mediated oxidative stress in IHD. Iron /zinc ratio, copper/zinc ratio may provide an additional index for prognosis of the IHD. 146 Dr. Mrs. JagtapVanita Ramesh and Dr. Dhanashri G. Kulkarni
The Effectiveness of Early Rehabilitation in Patients With Modified Radical Mastectomy

The aim of this prospective study was to investigate the effects of early onset rehabilitation program on shoulder mobility, functional status, lymphedema, and the incidence of postoperative complications in patients who had modified radical mastectomy. Fifty-seven women were randomly assigned to either treatment group or home exercise program groups, which were consisted of 27 and 30 patients, respectively. After removal of the drains, the patients were instructed to 15 sessions of individual rehabilitation program and continued with home-based physical activity program. The home exercise program groups only received a form including the exercises, which could be performed by themselves after removal of the drains. Range of motion of the shoulder joint and upper extremity circumferential difference were measured. Functional status was assessed by functional index score. Each patient was assessed preoperatively and then postoperatively at fifth day and first, third, and sixth months. The improvement in measurements of flexion, abduction, and adduction movements of the shoulder joint and the functional questionnaire scores were significantly better in treatment group. There was no statistically significant difference in the development of lymphedema and postoperative complications in both groups. Early onset rehabilitation program after modified radical mastectomy provides improvement in shoulder mobility and functional capacity without causing adverse effect in postoperative period.
Child abuse prevention program with POTS-based telehealth: a feasibility project.

Child abuse and neglect have devastating financial and psychological effects on children, families, and communities. Home visitation has been found to reduce the risk of child abuse by enhancing parent–child interaction and decreasing the incidence of physical punishment. This project was instituted to assess the acceptance and reliability of integrating inexpensive Plain Old Telephone Service (POTS)-based video technology (8 × 8 VIATV) into an existing program and to determine client and nurse satisfaction with the technology. At-risk families were recruited for the study if the mother was pregnant or had delivered within the past year and was available to participate in the study for 6 months. Subjects participated in the regular family intervention program in addition to having the POTS technology installed in their homes. Nurses also had the technology in their homes to give subjects access to them at all times. The POTS system had low acceptance by patients and nurses because of logistic and technica.
Ultra-reliable communication in a factory environment for 5G wireless networks: Link level and deployment study

The focus of this paper on mission-critical communications in a 5G cellular communication system. Technologies to provide ultra-reliable communication, with 99.999 % availability in a factory environment are studied. We have analysed the feasibility requirements for ultra-reliable communication and obtained the loss margins against path loss, shadow and fast fading. We also study the effect of increased interference due to higher deployment density on offered reliable rates and packet delays. Resource allocation schemes based on full and orthogonal resource sharing, as well as power control are compared. Last, the importance of multi-hop communication and multi-point coordination schemes are highlighted to improve the reliable communication in presence of interference and clutter.
EFFECT OF TEMPERATURE ON BREEDING RABBIT BEHAVIOUR

The aim of the study was to assess activity, position and behaviour parameters as indicators of heat stress in rabbits subjected to a circadian heat stress cycle. Ten does (80-105 days old) and 6 bucks (180 days old) individually housed in commercial wire cages were observed during 12 days 12 hours a day by means of videocameras using scan sampling at 5 minutes interval. Rabbits were divided in two buildings. Five females and three males were housed at 18.4oC mean temperature (control group) and the rest at 20.1oC, 17 hours a day, and at 27.9 oC the rest 7 hours (heat stress group). Position in relation to the corridor (watching it, avoiding it or perpendicular), activity (lying, sitting, prostrated or moving) and behaviour (grooming, exploring, resting, feeding and drinking) were assessed. Statistical analyses were performed with Genmod of SAS. No differences were found between treatments in feeding and drinking behaviour and animals moving. The presence of resting behaviour, watching the corridor and be prostrated was higher (P<0.05) in heat stress than control treatment and the contrary (P<0.05) was observed for lying, sitting and exploring. In the case of grooming, a clear compensation could be observed, rabbits reducing this activity in the heat stress period but increasing it just before and after this period in comparison to control animals. It is concluded that rabbits change their behaviour in moderate thermal stress, animals prostrated being a good indicator for the assessment of these conditions.
Fast Generalized Stochastic Linear Bandit

We study a generalized stochastic linear bandit problem and propose an algorithm 1 that enjoys fast update. The computational complexity of the update is O(d), 2 where d is the dimension of a context space. In comparison with other stochastic 3 linear bandit algorithms, our algorithm does not need to incrementally update the 4 inverse of a matrix so that it can avoid the O(d) computations. Yet, our problem 5 has different assumptions. The reward that the learner receives in each round is 6 binary and is generated by the logit model. We give some theoretical analysis of 7 the proposed algorithm for the regret upper bound. Furthermore, we consider a 8 distributed bandit setting such that there are some learners conducting the online 9 learning. We extend our algorithm to the distributed setting. By communica10 tion, the learners can achieve speedup in learning, which is measured by regret. 11 We also conduct experiments on two recommendation datasets (MovieLens and 12 Yahoo! Front Page) to show that our algorithm not only updates faster but also 13 achieves highly competitive click-through rate with the baseline. 14
A Corpus-driven Model of Arabic Morphosyntax: a Pilot Project

This article describes a pilot project of automatic morphosyntactic analysis system development and some results of our work. The approach, developed and adopted in this research, is caused by peculiarities of Arabic morphology and syntax, and implies parsing of morphosyntactic structures (both morphology and syntax) instead of traditional tokenization and division of language into morphology and syntax, which seems considerably artificial for many widespread phenomena of Arabic and leads to problems with parsing. Some existing Arabic corpora are discussed, some of them being even treebanks, but none of them having a common reliable underlying uniform formal model (a formal grammar of any kind) in public domain. The methodology of this project is described, and techniques used in the pilot study are discussed, including the software technologies adopted and developed. Current results are described with examples of morphosyntactic structures, immediate constituent classes (with information on dependencies), and code snippets of the grammar module.
Driver Behavior Classification in Crash and Near-Crash Events Using 100-CAR Naturalistic Data Set

Recently, several car insurance companies got interested in classifying the behavior of drivers. Usage-based insurance (UBI), such as Pay-How-you- Drive (PHYD) scheme, is an innovative idea in which the insurance premium changes based on the driving behavior. This behavior is usually evaluated in terms of vehicle-related variables such as distance, speed, and acceleration to determine the expected risk profile for drivers. In this paper, an additional level of classification in the hierarchy of profiling is proposed. Using the 100-CAR naturalistic driving study (NDS) data set, five different Hidden Markov Models (HMMs) are trained to determine the fault responsibility of a Subject Vehicle (SV) in a crash or near-crash events. Two specific driving situations, which are conflicts with leading and following vehicles, are investigated in this study. Results show that these models can achieve a reasonable classification accuracy.
On the Goldberger-Miyazawa-Oehme sum rule.

We show that the Goldberg-Miyazawa-Oehme sum rule provides a relatively model-independent way of predicting a value for the pion-nucleon coupling constant, which we find to be below the canonical value of {ital f}{sup 2}/4{pi}=0.079. The connections between this result, the low-energy theorem (LET) for pion photoproduction, and the pion-nucleon scattering lengths are discussed. We show that a value of {ital f}{sup 2}/4{pi} near 0.073 results in consistency between the LET, the Goldberger-Miyazawa-Oehme sum rule, and a Fubini-Furlan prediction for the difference between the isospin 1/2 and 3/2 pion-nucleon scattering lengths.
Responsiveness to methacholine, but not leukotriene D4, correlates with fractional exhaled nitric oxide in asthma

Correlation between fractional exhaled nitric oxide (FeNO) and responsiveness to inhaled leukotriene D4 (LTD4) and methacholine (MCh) might be different. This study aims to determine the correlation between FeNO and airway responsiveness to LTD4 and MCh, and to compare the airway responsiveness to inhaled LTD4 and MCh and FeNO in non‐smokers, patients without rhinitis and non‐smokers without rhinitis.