Miracle-dz/UniFAR-FTUs huggingface dataset:
A Design of Reconfigurable Negative Group Delay Circuit Without External Resonators

In this letter, we present the novel design and implementation of a microstirp line reconfigurable negative group delay circuit (NGDC) using a branch-line. Theoretical analysis shows that reconfigurable characteristics in the proposed circuit can be obtained by properly choosing the characteristic impedances of the branch-line and tuning only the termination resistance. Therefore, the proposed reconfigurable NGDC does not require any extra resonators. For experimental validation, the proposed circuit was designed and fabricated for a wideband code division multiple access downlink frequency operating at a center frequency ( f0) of 2.14 GHz. Measurement results show the group delays variation of -2 ns to -10 ns with signal attenuation variation of -25 dB to -36.6 dB at f0. For enhancement of the negative group delay bandwidth, two NGDCs operating at slightly different center frequencies are cascaded and measured.
Liver Transplantation for Hepatocellular Carcinoma in Young Adults: A United Network for Organ Sharing Study.

PURPOSE Orthotopic liver transplantation (OLT) is curative for hepatocellular carcinoma (HCC). HCC is typically a disease of older adults (OAs); therefore, characteristics and outcomes of OLT for young adults (YAs) (ages 18-40) are not described. The objective of this study was to assess the characteristics and outcomes of YAs with HCC receiving OLT and compare these to OAs (ages >40 years). METHODS YAs with HCC who had OLT from the United Network for Organ Sharing (UNOS) database were included in this study. As a comparison group, OAs with HCC were matched 4:1 to the YA group. Descriptive statistics of demographics, comorbidities, and outcomes were generated. Kaplan-Meier product limit estimates were used to assess patient and graft survival. Conditional logistic regression and Cox proportional hazards frailty models were used to compare the groups. RESULTS A total of 464 YAs received OLT for HCC. The most common underlying liver diseases were hepatitis C virus (21.3%), hepatitis B virus (HBV, 15.5%), and autoimmune/cholestatic disease (12.3%). An increased number of YAs received OLT for HCC after implementation of model for end-stage liver disease scoring. One thousand two hundred eighty OAs served as the comparison group. Post-transplant 5-year survival was 73.1% in YAs with a retransplantation rate of 7.8%. In OAs, survival and retransplantation rates were lower (68.6% p = 0.093; 4.3% p = 0.001). CONCLUSION Four hundred sixty-four YAs with HCC received OLT in the UNOS database. Compared to the older population, survival and retransplantation rates were higher. HBV, which is vaccine preventable, is a frequent contributor to HCC in YAs.
Admission conditions and graduates’ employability

In a context of increasing competition for students, admission conditions have been used as an instrument in a strategy of differentiation. Such a strategy is guided by short‐run concerns, that is, the immediate need to attract more students. This article takes a longer term view, by examining graduates’ employability. The authors find that tougher admission conditions (namely, a mandatory mathematics examination) appear to be linked with lower unemployment propensity. Previous studies, however, have found that those programmes face lower demand when compared to other studies. These results suggest that students’ choices may be based on insufficient information on returns to higher education investment. That information failure indicates that a government intervention may be due.
Analyzing Invariance of Frequency Domain based Features from Videos with Repeating Motion

This paper discusses an approach, which allows classifying videos by frequency spectra. Many videos contain activities with repeating movements. Sports videos, home improvement videos, or videos showing mechanical motion are some example areas. Motion of these areas usually repeats with a certain main frequency and several side frequencies. Transforming repeating motion to its frequency domain via FFT reveals these frequency features. In this paper we explain how to compute frequency features for video clips and how to use them for classifying. The experimental stage of this work focuses on the invariance of these features with respect to rotation, reflection, scaling, translation and time shift.
Resistance of Escherichia coli to penicillins: fine-structure mapping and dominance of chromosomal beta-lactamase mutations

Seven Escherichia coli K-12 mutants with a lowered chromosomal beta-lactamase activity were analyzed genetically. The beta-lactamase-negative mutants isolated from ampA1-carrying strains (resistant to 10 microgram of ampicillin per ml) all carried genetic lesions very close to the ampA1 mutation, which was still present. In an earlier report, two of the mutations mediating a beta-lactamase-negative phenotype (L. G. Burman, T. Park, E. B. Linström, and H. G. Boman, J. Bacteriol. 116:123-130, 1973) were shown to have occurred in the structural gene for beta-lactamase, designated ampC. It is suggested that all beta-lactamase-negative mutants studied here were altered in ampC. The relative order of ampC mutations was (ampC1, ampC8)-ampC9-(ampC12, ampC14)-ampC11, and the gene order was found to be ampC-1mpA-purA. The ampA1 allele was dominant over its wild-type allele but acted only cis and not trans, suggesting that ampA is the promoter or operator region for ampC. A gene dosage effect was found for strains homozygous for ampA+ ampC+ or ampA1 ampC+. Heterozygotes carrying the ampC8 allele on the chromosome showed an apparent derepression of the episomal ampC allele, suggesting a role for beta-lactamase in its own regulation.
Views of immunology: effector T cells

Summary: For many intracellular bacteria, both adaptively acquired and innately encoded effector T cells play a central role in the control, and in some cases, clearance of these pathogens. Through the rapid identification of those cells harboring intracellular bacteria, effector T cells have the capacity to both directly control the infection and shape the immune response to the pathogen. Here, we review the mechanisms by which effector T cells control intracellular infection and emphasize the means by which they recognize their targets. As will become evident, the diversity of both redundant and non‐redundant effector mechanisms in conjunction with broad recognition of both protein and non‐protein antigens allows for the identification of a broad array of bacterial pathogens and lessens the likelihood of immune evasion.
Affective Historiography: Schindler's List, Melodrama and Historical Representation

With Hayden White's notion of the "content of the form" of narrative as a starting point, this article argues that the melodramatic form of Steven Spielberg's Schindler's List (1993) constitutes a distinct mode of historical representation that must be critically accounted for alongside the manifest content of the film. This argument is made by linking Linda Williams' discussion of melodrama as an operative mode concerned more with the emotional retrieval of innocence than with rational psychological causality to Peter Brooks's invocation of Freudian case studies to understand how narratives can work towards the revelation of an original "truth" whose ontological status is unclear. Through this integration of Williams and Brooks, the melodramatic quality at play in Schindler's List, which is often read as a liability against the film's representation of history as it affords access to registers of emotional excess that cannot be explained through narrative logic, can be understood as an essential feature of the film's historiography. Moreover, given this tendency towards emotional excess rather than rational causality, this article suggests that the melodramatic historical form can productively address (although not necessarily resolve) the epistemological challenges posed by the Holocaust to representational rendering.
Quantitative Allelic Test—A Fast Test for Very Large Association Studies

Advances in high throughput technology have enabled the generation of unprecedented amounts of genomic data (e.g., next‐generation sequence data, transcriptomics, metabolomics, and proteomics), which promises to unravel the genetic architecture of complex traits. These discoveries may lead to novel therapeutic targets, guide disease prevention, and enable personalized medicine. However, the pace of data generation surpasses the ability to process and analyze the vast amounts of data. For example, in a typical study of transcription regulation, the relationship between more than 1 million genetic variants and 10,000 transcript levels are explored, requiring tens of billions of tests. In order to address this problem, we propose a fast, accurate, and robust method that can assess the significance of associations between quantitative phenotypes and genotypes. The method is an extension of the allelic test commonly used in case–control studies for the analysis of quantitative traits. We show the asymptotic equivalence of the proposed test to linear regression results. We also reduce a generalized linear regression problem to the comparison of two groups, which can handle nonnormal and survival time phenotypes.
Plasticité cristalline en présence de grandes déformations et d'endommagement

Ce travail s'inscrit dans le cadre de la plasticite cristalline. Sa premiere motivation est le developpement d'une approche couplee, capable de prendre en compte l'interaction entre la plasticite et l'environnement dans les tubes de zircaloy des centrales nucleaires. La premiere etude sur la plasticite du zircaloy, influencee par l'environnement, a ete menee par (O.Diard, G.Cailletaud, ENSMP). Les conditions d'interaction y sont bien caracterisees, et un premier modele representant l'endommagement des joints de grains suite a l'interaction avec l'iode y est propose. Il restait a ameliorer l'integration numerique, et a utiliser le modele pour des structures plus realistes. Par ailleurs, il s'agit desormais de representer l'endommagement intergranulaire, suivi de l'ecrouissage transgranulaire, observe experimentalement. Afin d'atteindre ces objectifs, plusieurs points ont du etre abordes. Une modelisation plus pertinente est ici utilisee pour les joints de grains, et une formulation du modele en transformations finies est proposee. L'objectif initial a donc ete elargi. En dehors des calculs d'agregats endommages du zircaloy, on trouvera les calculs d'une eprouvette de cuivre, maillee en 3d. C'est une etape indispensable pour tester la methode numerique dans le cas de deformations moderees. Quelques resultats concernant la methode numerique sont egalement presentes. Le manuscrit est organise en trois parties. Tout d'abord, la partie A est consacree a la description des modeles. Les outils numeriques sont ensuite expliques dans la partie B. Enfin,la partie C presente les resultats numeriques. Dans la premiere partie, la formulation initiale d'un modele du monocristal (section 1) est tout d'abord exposee; puis vient le nouveau modele DOS (Damage, Opening and Sliding) propose pour une description de joints de grains (section 2); enfin la derniere section est consacree aux algorithmes en transformations finies (section 3). L'elasticite, la plasticite J2, la plasticite cristalline, et finalement le modele DOS, sont successivement examines. Le schema implicite est utilise pour l'integration numerique. Dans la Partie B, une methode de generation de maillages particuliers, comportant une representation explicite des joints de grains, avec de veritables eleements finis, est exposee. Cette procedure est developpee de facon systematique, dans le cas 2d et 3d (section 4). Puis, le principe de calculs avec couplage est explique (section 5). Les modeles du materiau et les outils numeriques sont appliques aux calculs d'aggregats de zircaloy dans la section 7 de la partie C: une simulation de l'effet de corrosion sous contraintes des tubes du zircaloy dans l'environement de l'iode est proposee. Afin de montrer les possibilites de notre algorithme et d'avoir une comparaison avec l'experience, la section 6 montre les resultats de calcul de l'etat contrainte-deformation d'une eprouvette de cuivre, testee a l'Universite de Leoben (O.Kolednik, et al.).
Sample Size Considerations for GEE Analyses of Three‐Level Cluster Randomized Trials

Summary Cluster randomized trials in health care may involve three instead of two levels, for instance, in trials where different interventions to improve quality of care are compared. In such trials, the intervention is implemented in health care units (“clusters”) and aims at changing the behavior of health care professionals working in this unit (“subjects”), while the effects are measured at the patient level (“evaluations”). Within the generalized estimating equations approach, we derive a sample size formula that accounts for two levels of clustering: that of subjects within clusters and that of evaluations within subjects. The formula reveals that sample size is inflated, relative to a design with completely independent evaluations, by a multiplicative term that can be expressed as a product of two variance inflation factors, one that quantifies the impact of within‐subject correlation of evaluations on the variance of subject‐level means and the other that quantifies the impact of the correlation between subject‐level means on the variance of the cluster means. Power levels as predicted by the sample size formula agreed well with the simulated power for more than 10 clusters in total, when data were analyzed using bias‐corrected estimating equations for the correlation parameters in combination with the model‐based covariance estimator or the sandwich estimator with a finite sample correction.
Effect of Energy Drink on Bone Formation in the Expanded Inter-Premaxillary Suture

Abstract Maxillary expansion of the median palatal suture is a common procedure in orthodontics. Even after retention, there is a strong tendency to relapse in the expanded suture. The authors’ objectives are to accelerate the bone formation process in the expanded suture and to reduce the required retention time by using an energy drink (ED). Twenty rats were divided into 2 groups (n = 20). The expansion-only group was defined as the control group (Group C). The other group was defined as the expansion-plus-energy drink group (Group ED). In Group ED, ED was administered systemically through oro-gastric tubes after the expansion period. After 5 days of expansion, the springs were removed and replaced with short lengths of rectangular retaining wire. Tooth separation was maintained for 12 days. Histomorphometric analysis showed significant differences between the 2 groups in terms of newly formed bone (P = 0.018) and the bone area (P = 0.007). For the parameters that were investigated, Group ED had better results than Group C. These results show that systemic administration of an ED during the early stages of the orthopedic expansion of the inter-maxillary suture areas can stimulate bone formation and decrease the time required for retention.
Efficacy of the Combination of Tetracycline, Amoxicillin, and Lansoprazole in the Eradication of Helicobacter pylori in Treatment-Naïve Patients and in Patients Who Are Not Responsive to Clarithromycin-Based Regimens: A Pilot Study

Background/Aims The aim of this study was to evaluate the eradication rate of a triple therapy regimen that included a proton pump inhibitor, amoxicillin, and tetracycline instead of clarithromycin in treatment-Naïve patients and in patients who did not respond to standard triple therapy. Methods This study included 110 patients infected with Helicobacter pylori. Patients in groups A and B were treatment-Naïve, and those in group C were not responsive to previous standard triple therapy. Patients in group A (n=40) received lansoprazole 30 mg b.i. d. , amoxicillin 1,000 mg b.i. d. , and clarithromycin 500 mg b.i. d. for 14 days. Patients in groups B (n=40) and C (n=30) received lansoprazole 30 mg b.i. d. , amoxicillin 1,000 mg b.i. d. , and tetracycline 500 mg q.i. d. for 14 days. Results In group A, eradication was achieved in 18 (45%) of the 40 patients included in the intention-to-treat (ITT) analysis and in 18 (47.4%) of the 38 patients included in the per-protocol (PP) analysis. In group B, eradication was achieved in 15 (37.5%) of the 40 patients included in the ITT analysis and in 15 (39.3%) of the 38 patients included in the PP analysis. In group C, eradication was achieved in 14 (46.6%) of the 30 patients included in the ITT analysis and in 14 (43.8%) of the 29 patients included in the PP analysis. There was no statistically significant difference among the 3 groups with regard to eradication rates (p>0.05). Conclusions Despite the low rate of resistance to tetracycline, the combination of lansoprazole, amoxicillin, and tetracycline instead of clarithromycin is not a good option for the eradication of H. pylori.
Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90

GRP94, the endoplasmic reticulum paralog of Hsp90, is regulated by adenosine nucleotides that bind to its N-terminal regulatory domain. Because of its weak affinity for nucleotides, the functionally relevant transition in GRP94 is likely to be between the unliganded and nucleotide-bound states. We have determined the structure of the unliganded GRP94 N-domain. The helix 1-4-5 subdomain of the unliganded protein adopts the closed conformation seen in the structure of the protein in complex with inhibitors. This conformation is distinct from the open conformation of the subdomain seen when the protein is bound to ATP or ADP. ADP soaked into crystals of the unliganded protein reveals an intermediate conformation midway between the open and closed states and demonstrates that in GRP94 the conversion between the open and closed states is driven by ligand binding. The direction of the observed movement in GRP94 shows that nucleotides act to open the subdomain elements rather than close them, which is contrary to the motion proposed for Hsp90. These observations support a model where ATP binding dictates the conformation of the N-domain and regulates its ability to form quaternary structural interactions.
Erreurs des apprenants de L2 dans les dictées

Le present article sʼinteresse aux caracteristiques des erreurs dans les dictees des etudiants slovenes de francais. La raison pour laquelle nous avons choisi dʼanalyser les dictees consiste dans le fait que la dictee est un exercice assez complexe car elle met a lʼepreuve aussi bien la comprehension orale de lʼapprenant que ses connaissances en orthographe et en regles grammaticales. Dans un premier temps, nous nous sommes plus particulierement interesses a lʼapparition de certains types dʼerreurs. Dans ce but, nous avons etabli un classement des erreurs qui avait pour mission de repertorier differents types dʼerreurs que lʼon peut trouver dans ce type de discours ecrit. Ensuite, nous nous sommes penches sur les causes possibles de ces erreurs pour finalement proposer quelques pistes susceptibles dʼy remedier. Lʼanalyse des dictees a demontre que les erreurs plus nombreuses proviennent de lʼorthographe dʼusage, suivent les erreurs de nature lexicale et lʼoubli dʼun mot ou dʼun syntagme. Parmi les principales causes de ces types dʼerreurs, on pourrait mentionner une orthographe francaise difficile, un vocabulaire insuffisant et un manque dʼautomatismes. Pour diminuer au maximum le nombre dʼerreurs dans les dictees, lʼengagement, la persistance et une participation active de la part de lʼapprenant semblent indispensables. Sans oublier, bien sur, une approche efficace du professeur, qui proposera differentes activites qui auront pour but dʼameliorer leurs competences langagieres sollicitees dans les dictees.
Misclassification of coronary heart disease in mortality statistics. Evidence from the WHO-MONICA Ghent-Charleroi Study in Belgium.

STUDY OBJECTIVE: To validate the Belgian vital statistics for coronary heart disease (CHD) on the basis of an independent acute myocardial infarction (AMI) register, carried out as part of the WHO-MONICA project. DESIGN: Records of fatal cases of AMI in the WHO-MONICA register were individually linked to the corresponding death certificates. SETTING: Since 1983, the WHO-MONICA Collaborating Centre Ghent/Charleroi registers all fatal and non-fatal AMI in the age group 25-69 years in two geographical areas, Ghent in the northern Dutch speaking part and Charleroi in the southern French speaking part of Belgium. Registration is done according to the MONICA protocol. The official vital statistics in Belgium are published on a yearly basis. They are essentially a reflection of the "underlying" causes of death, coded according to the 9th revision of the International Classification of Diseases (ICD). The study was undertaken in the period 1983-1991. MAIN RESULTS: Out of a total of 741 (Ghent) and 934 (Charleroi) well documented MONICA fatal cases of AMI, 492 (66.4%) and 641 (68.6%), respectively, were officially labelled as CHD (ICD code 410-414); 438 (59.1%) and 385 (41.2%), respectively, were officially labelled as AMI (ICD code 410). A substantial fraction of the MONICA AMI cases--27.1% in Ghent and 38.2% in Charleroi--was coded as "other forms of CHD" (ICD 411-414) or as "other forms of heart disease" (ICD 420-429). The remaining MONICA AMI cases--13.8% in Ghent and 20.6% in Charleroi--were classified in either very aspecific (for example, atherosclerosis, ICD 440) or totally unrelated ICD codes (for example, neoplasm, ICD 140-239). CONCLUSIONS: It is concluded from the results in this paper that a substantial part of all deaths caused by CHD in Belgium are labelled with incorrect ICD codes and are therefore misclassified in the official mortality statistics for Belgium. This is partly caused by a "drainage" of cases towards less specific CHD related ICD categories. A considerable fraction, however, seems to be absolutely misclassified.
The Use of Jewish Scriptures in 1 Thessalonians

Study of the use of Jewish Scriptures (henceforth JS) in the New Testament (henceforth NT) has had a distinguished history in biblical scholarship, and appears as a topic of modern interest particularly in the last forty years. A glance at the authors and publishing houses initially involved in this area of analysis suggests that it was primarily a concern of scholarly Evangelicals. Several factors, however, have caused scholars from most other bands of the exegetical spectrum to become engaged with this topic. One of these certainly is the discovery of the Qumran materials, which gave the academic community a new perspective on the biblical text. Another is the critical
Magnets for Sarcasm: Making Sarcasm Detection Timely, Contextual and Very Personal

Sarcasm is a pervasive phenomenon in social media, permitting the concise communication of meaning, affect and attitude. Concision requires wit to produce and wit to understand, which demands from each party knowledge of norms, context and a speaker’s mindset. Insight into a speaker’s psychological profile at the time of production is a valuable source of context for sarcasm detection. Using a neural architecture, we show significant gains in detection accuracy when knowledge of the speaker’s mood at the time of production can be inferred. Our focus is on sarcasm detection on Twitter, and show that the mood exhibited by a speaker over tweets leading up to a new post is as useful a cue for sarcasm as the topical context of the post itself. The work opens the door to an empirical exploration not just of sarcasm in text but of the sarcastic state of mind.