Miracle-dz/UniFAR-FTUs huggingface dataset:
Sertoli Cell Tumor Causing Prepubertal Gynecomastia in a Boy with Peutz-Jeghers Syndrome: The Outcome of 1-Year Treatment with the Aromatase Inhibitor Testolactone

Peutz-Jeghers syndrome (PJS) is a rare disorder characterized by benign intestinal hamartomatous polyps and mucocutaneous pigmentation, and with an increased risk for intestinal and extra-intestinal neoplasms. Sertoli cell tumors in boys with PJS have been increasingly recognized as a cause of prepubertal gynecomastia. However, an association between nephrocalcinosis and PJS has not been reported before. We report on a 7.25-year-old boy with PJS, bilateral gynecomastia, Sertoli cell tumor and nephrocalcinosis, and present the outcome of 1-year treatment with the aromatase inhibitor testolactone. The patient presented with bilateral breast and testis enlargement, and mucocutaneous pigmentation. Testicular ultrasound revealed parenchymal multiple microcalcifications. Histopathological examination was consistent with Sertoli cell tumors. Nephrocalcinosis due to idiopathic renal hypercalciuria was also detected. The aromatase inhibitor testolactone was begun in an attempt to prevent acceleration in skeletal maturation. One-year treatment with testolactone reduced the breast base diameter from 7 to 3 cm, and bone age advanced 1.2 years during this period. Our case demonstrates that waiting for the effect of aromatase inhibitors on gynecomastia before making a decision for mastectomy may be a reasonable option. We also consider that the association between PJS and nephrocalcinosis may be a coincidence.
Adquisición y Procesamiento de la Señal Electrocardiográfica de Alta Resolución para la Identificación de Enfermedades Cardiovasculares como el Mal de Chagas

Este articulo presenta el desarrollo de un sistema de adquisicion y procesamiento de la senal electrocardiografica (ECG) de alta resolucion (ECGAR). El proyecto consta de una etapa de hardware y una de software. La etapa de hardware permite la captacion de la senal ECG del paciente y la digitalizacion de las 12 derivaciones en forma simultanea. Las caracteristicas de las senales ECGAR son adecuadas para aplicar tecnicas de analisis especializadas que permitan estudiar enfermedades cardiovasculares de metabolismo retardado, como el mal de Chagas.
Results of single-event multilevel orthopedic surgery in children withcerebral palsy

Background: Single-event multilevel orthopedic surgery is a modern approach in the operative treatment of children with cerebral palsy. Methods: Single-event multilevel orthopedic surgery was carried out in 108 patients with cerebral palsy. Patients’ average age was 11.3±1.7 years. Surgical results were analyzed at follow-up after 18 to 24 months, by way of detailed physical examination, functional assessment, imaging, the Edinburgh Visual Gait Score and Gillette Functional Assessment Questionnaire. Results: In our series, 647 procedures were performed during 141 surgeries. Patients had an average of 4.59 procedures per surgery. Observational gait analysis showed an improvement in stance and swing gait phases in ambulatory children. According to the Gillette Functional Assessment Questionnaire, an increase of functional level was noted in 50 patients but did not change in 32 patients. Conclusions: For children with cerebral palsy, single-event multilevel surgery is defined as two or more surgical procedures of the soft tissue or bone at two or more anatomical levels during one operative procedure. In cases where a large volume of surgery is required, two separate operations with a short break in between, but requiring only one hospital admission and one rehabilitation period, are also included. This approach requires adapted methods of surgical intervention, and appropriate methods of anesthesia and pain control in the postoperative period to the start of rehabilitation. Compliance with the above principles allowed the necessary correction of orthopedic complications to be achieved in all cases.
MEM-tunable and wavelength selective receiver front end

This paper presents a tunable and wavelength selective receiver structure for data monitoring purposes. The tunability is created by a microelectromechanic engineered membrane chip. The optical-electrical conversion takes place in a second chip. Both chips together from the wavelength selective Fabry-Perot cavity. The realized device features a free-spectral range of 35 nm, and a full-width half-maximum of 0.15 nm. The capability of the fiber-coupled device is demonstrated in a 2 Gbit/s/channel wavelength-division multiplexed system.
Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3

During the process of autophagy, autophagosomes undergo a maturation process consisting of multiple fusions with endosomes and lysosomes, which provide an acidic environment and digestive function to the interior of the autophagosome. Here we found that a fusion protein of monomeric Red-fluorescence protein and LC3, the most widely used marker for autophagosomes, exhibits a quite different localization pattern from that of GFP-LC3. GFP-LC3 loses fluorescence due to lysosomal acidic and degradative conditions but mRFP-LC3 does not, indicating that the latter can label the autophagic compartments both before and after fusion with lysosomes. Taking advantage of this property, we devised a novel method for dissecting the maturation process of autophagosomes. mRFP-GFP tandem fluorescent-tagged LC3 (tfLC3) showed a GFP and mRFP signal before the fusion with lysosomes, and exhibited only the mRFP signal subsequently. Using this method, we provided evidence that overexpression of a dominant negative form of Rab7 prevented the fusion of autophagosomes with lysosomes, suggesting that Rab7 is involved in this step. This method will be of general utility for analysis of the autophagosome maturation process.
Implementation of a novel approach for the simulation of Cognition based on Situation-Operator-Modeling and high-level Petri Nets

This contribution presents the concept and implementation of a novel architecture for Cognitive Technical Systems, which is methodically based on Situation-Operator-Modeling realizing the representation of the real world's structure in a unique and homogeneous manner. It is realized by high-level Petri Nets and a related software tool providing graphical modeling and simulation. As a special feature, several instances of the cognitive architecture can be combined to reduce the complexity of the real world by a problem-oriented encapsulation of different action spaces. Finally, an example focusing the interaction of an agent in a dynamic environment is given.
Single-trial detection of visual evoked potentials by common spatial patterns and wavelet filtering for brain-computer interface

Event-related potentials (ERPs) are widely used in brain-computer interface (BCI) systems as input signals conveying a subject's intention. A fast and reliable single-trial ERP detection method can be used to develop a BCI system with both high speed and high accuracy. However, most of single-trial ERP detection methods are developed for offline EEG analysis and thus have a high computational complexity and need manual operations. Therefore, they are not applicable to practical BCI systems, which require a low-complexity and automatic ERP detection method. This work presents a joint spatial-time-frequency filter that combines common spatial patterns (CSP) and wavelet filtering (WF) for improving the signal-to-noise (SNR) of visual evoked potentials (VEP), which can lead to a single-trial ERP-based BCI.
Mental health of Cambodian refugees 2 decades after resettlement in the United States.

CONTEXT Little is known about the long-term mental health of trauma-exposed refugees years after permanent resettlement in host countries. OBJECTIVE To assess the prevalence, comorbidity, and correlates of psychiatric disorders in the US Cambodian refugee community. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional, face-to-face interview conducted in Khmer language on a random sample of households from the Cambodian community in Long Beach, Calif, the largest such community in the United States, between October 2003 and February 2005. A total of 586 adults aged 35 to 75 years who lived in Cambodia during the Khmer Rouge reign and immigrated to the United States prior to 1993 were selected. One eligible individual was randomly sampled from each household, with an overall response rate (eligibility screening and interview) of 87% (n = 490). MAIN OUTCOME MEASURES Exposure to trauma and violence before and after immigration (using the Harvard Trauma Questionnaire and Survey of Exposure to Community Violence); weighted past-year prevalence rates of posttraumatic stress disorder (PTSD) and major depression (using the Composite International Diagnostic Interview version 2.1); and alcohol use disorder (by the Alcohol Use Disorders Identification Test). RESULTS All participants had been exposed to trauma before immigration. Ninety-nine percent (n = 483) experienced near-death due to starvation and 90% (n = 437) had a family member or friend murdered. Seventy percent (n = 338) reported exposure to violence after settlement in the United States. High rates of PTSD (62%, weighted), major depression (51%, weighted), and low rates of alcohol use disorder were found (4%, weighted). PTSD and major depression were highly comorbid in this population (n = 209; 42%, weighted) and each showed a strong dose-response relationship with measures of traumatic exposure. In bivariate analyses, older age, having poor English-speaking proficiency, unemployment, being retired or disabled, and living in poverty were also associated with higher rates of PTSD and major depression. Following multivariate analyses, premigration trauma remained associated with PTSD (odds ratio [OR], 2.08; 95% CI, 1.37-3.16) and major depression (OR, 1.56; 95% CI, 1.24-1.97); postmigration trauma with PTSD (OR, 1.65; 95% CI, 1.21-2.26) and major depression (OR, 1.45; 95% CI, 1.12-1.86); and older age with PTSD (OR, 1.76; 95% CI, 1.46-2.13) and major depression (OR, 1.47; 95% CI, 1.15-1.89). CONCLUSION More than 2 decades have passed since the end of the Cambodian civil war and the subsequent resettlement of refugees in the United States; however, this population continues to have high rates of psychiatric disorders associated with trauma.
Tepper School of Business 7-2007 Counting CSP Solutions Using Generalized XOR Constraints

We present a general framework for determining the number of solutions of constraint satisfaction problems (CSPs) with a high precision. Our first strategy uses additional binary variables for the CSP, and applies an XOR or parity constraint based method introduced previously for Boolean satisfiability (SAT) problems. In the CSP framework, in addition to the naive individual filtering of XOR constraints used in SAT, we are able to apply a global domain filtering algorithm by viewing these constraints as a collection of linear equalities over the field of two elements. Our most promising strategy extends this approach further to larger domains, and applies the so-called generalized XOR constraints directly to CSP variables. This allows us to reap the benefits of the compact and structured representation that CSPs offer. We demonstrate the effectiveness of our counting framework through experimental comparisons with the solution enumeration approach (which, we believe, is the current best generic solution counting method for CSPs), and with solution counting in the context of SAT and integer programming.
Mitogen-activated protein kinases regulate vascular reactivity after hemorrhagic shock through myosin light chain phosphorylation pathway

BACKGROUND Vascular hyporeactivity played an important role in many critical illness including shock or sepsis, but the mechanisms are incompletely understood. The objective of the present study was to investigate the roles of major mitogen-activated protein kinases (MAPKs extracellular signal-regulated kinase [ERK], p38 MAPK, and jun NH2-terminal kinase [JNK]) on vascular reactivity and the mechanisms. METHODS With superior mesenteric arteries from hemorrhagic shock rats, the role of p38 MAPK, ERK, and JNK in the regulation of vascular reactivity following shock and their relationship to myosin light chain (MLC20) phosphorylation–dependent pathway was observed. RESULTS ERK, p38 MAPK, and JNK activities in superior mesenteric arteries were increased at early shock and decreased at late shock. Stimulation of MAPKs with angiotensin II (AngII) increased the vascular reactivity, calcium sensitivity, and MLC20 phosphorylation. The increasing effect of AngII on vascular reactivity was antagonized by ERK, p38 MAPK, and JNK inhibitors, while the effect of AngII on calcium sensitivity was only blocked by ERK and p38 MAPK inhibitor, but not by JNK inhibitor. AngII increased the activity of protein kinase C–dependent phosphatase inhibitor of 17-kD (CPI17), integrin-linked kinase (ILK), and zipper-interacting protein kinase (ZIPK), The effect of AngII on CPI17 was blocked by ERK and p38 MAPK inhibitor, while the effect of AngII on ILK and ZIPK was only blocked by ERK inhibitor. CONCLUSION MAPKs participated in the regulation of vascular reactivity during shock. ERK and p38 MAPK is mainly through ILK, ZIPK, and CPI17-mediated MLC20 phosphorylation–dependent pathway, while JNK may be involved in the regulation of vascular reactivity by other mechanisms.
Functional outcomes after the Ross (pulmonary autograft) procedure assessed with magnetic resonance imaging and cardiopulmonary exercise testing

Objective To assess autograft, homograft and ventricular function, as well as exercise capacity, in adult patients who have undergone the Ross procedure. Setting Single centre paediatric and adult congenital heart disease unit. Patients 45 subjects (24.6 years, range 16.9–52.2 years) who underwent the Ross procedure between 1994 and 2006 (8.1 years after the Ross operation, range 2.0–14.0 years). Interventions Cardiovascular magnetic resonance imaging, echocardiography and cardiopulmonary exercise testing. Main outcome measures Autograft and homograft stenosis, and regurgitation. Autograft size. Biventricular function, scar volume and exercise capacity. Results Mean autograft regurgitation was 6.8%±8.3% (trivial regurgitation) and diameter was 40.0±7.0 mm. Mean homograft velocity was 2.4±0.6 m/s (mild-moderate stenosis) and regurgitation was 6.1%±8.3% (trivial regurgitation). Biventricular systolic function was normal (LV EF 63.1±6.4% and RV EF 60.1%±7.6%). In 38% of cases there was evidence of LV scar, mostly noted within the inter-ventricular septum. The mean exercise capacity achieved was 87%±22% of predicted. There was no correlation between exercise capacity and ventricular function or scar. Conclusion This study demonstrates minor autograft and homograft dysfunction in the majority of patients after the Ross procedure, associated with good ventricular function and exercise capacity. In addition, minor scar was present in a third of patients with no functional consequences.
Using the Taguchi methods to study the balance control of a rotary inverted pendulum

The objective of this research was to design controllers for balancing a rotary inverted pendulum. The controllers designed by the pole-placement method and the linear-quadratic regulator (LQR) method were discussed, and experiments and simulation were conducted to study the performance of the controllers. By using an L9 orthogonal array proposed in the Taguchi methods, the appropriate feedback gain used in the LQR controller can be efficiently found among 120 combinations of different feedback gains. Various lengths of the links in the rotary inverted pendulum were simulated in order to understand the relationship between the lengths of the links and feedback gains.
Walking the Talk: Insights Into Dynamics of Race and Gender for Nurses

This article explores how the dynamics of violence and support for nurses are influenced by the intersections of race, gender, and other social relations in various practice settings. Utilizing a qualitative study design, situated in the naturalistic and critical paradigms, this article is grounded in the experiences of key informants (KIs), each possessing significant expertise on issues of equity and violence, as well as insight into the current practice settings in Ontario, Canada. The individual KI interviews were analyzed using conventional qualitative content analysis, with its focus on capturing emerging insights. The findings reflect the everyday nature of gendered and racialized violence, the influence of setting and the effectiveness of existing resources. Professional, organizational, and broader policy implications are discussed to support diversely situated nurses within their various practice environments.
Hybridising Tabu Search with Optimisation Techniques for Irregular Stock Cutting

Sequential meta-heuristic implementations for the irregular stock-cutting problem have highlighted a number of common problems. The literature suggests a consensus that it is more efficient to allow configurations with overlapping pieces in the solution space and to penalise these in the evaluation function. However, depending on the severity of the penalty this relaxation results in a tendency to converge toward infeasible solutions or to seek out feasible solutions at the expense of overall quality. A further problem is encountered in defining a neighbourhood search strategy that can deal with the infinite solution space inherent in the irregular stock-cutting problem. The implementation in this paper adopts a hybrid tabu search approach that incorporates two very different optimisation routines that utilise alternative neighbourhoods to address the described problems.
Chemical composition of endemic Centaurea austro-anatolica and studies of its antimicrobial activity against multi-resistant bacteria

Chemical composition of endemic Centaurea austro-anatolica and studies of its antimicrobial activity against multi-resistant bacteria Hexane, chloroform, ethyl acetate and ethanolic extracts of the aerial parts of Centaurea austro-anatolica Hub. -Mor. (Asteraceae) were evaluated against microorganisms, including multiresistant bacteria, using a paper disc diffusion method. The chloroform extract exhibited significant antibacterial activity toward all bacteria tested. The chemical composition of the chloroform extract was determined by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The major compounds of the extract were caryophyllene oxide (21.32 %), spathulenol (10.86 %), n-tricosanol (9.58 %) and geranyl isovalerate (8.71 %). Kemijski sastav endemske biljke Centaurea austro-anatolica i ispitivanje antimikrobnog djelovanja protiv multi-rezistentnih bakterija Heksanski, kloroformski, etil-acetatni i etanolni ekstrakti vršnih dijelova biljke C. austro-anatolica Hub. -Mor. (Asteraceae) ispitivani su na antimikrobno djelovanje protiv multi-rezistentnih bakterija, koristeći difuzijsku metodu na papirnom disku. Kloroformski ekstrakt pokazao je značajno antibakterijsko djelovanje protiv svih testiranih bakterija. Kemijski sastav tog ekstrakta određivan je plinskom kromatografijom (GC) i plinskom kromatografijom-spektrometrijom masa (GC-MS). Najvažniji sastojci ekstrakta bili su kariofilen oksid (21,32 %), spatulenol (10,86 %), n-trikozanol (9,58 %) i geranil izovalerat (8,71 %).
RLGS profile segmentation via a SVM

This paper presents a new and fast segmentation algorithm, capable of incorporating expert's knowledge and expertise in a straightforward manner, to detect DNA spots in a restriction landmark genomic scanning (RLGS) profile. A RLGS profile is a gray scale image obtained in a X-ray film containing hundreds of dark spots corresponding to certain DNA fragments labeled by radioactive markers. Extracting these DNA spots is a very challenging task due to their fuzzy boundaries against noisy background regions having non-uniform intensity variations. The proposed algorithm, utilizing a support vector machine, is found to be successful to detect and extract DNA spots in a RLGS profile.
Teacher attunement to peer‐nominated aggressors

This study examined the associations between teacher attunement to aggressive students and students' characteristics in a sample (n = 278) of youth in 5th-grade classrooms with the assumption that certain student characteristics may either prime or hinder teachers' attunement to aggressive students. Teacher attunement was measured as the agreement between teacher- and peer-nominations for students who start fights. Teachers rated their students on the following characteristics: academic competence, affiliation, popularity, internalizing behavior, and Olympian qualities. Higher affiliation, popularity, and internalizing behavior were associated with decreased odds for teacher attunement to aggressive youth. Higher Olympian qualities were associated with increased odds for teacher attunement to aggressive youth. Implications for interventions are discussed. Aggr. Behav. 43:263-272, 2017. © 2016 Wiley Periodicals, Inc.
A single scatter improvement for beam propagation methods

The beam propagation methods are widely used in numerical simulations of optical waveguides that change gradually in the propagation direction. However, their accuracy is still limited if the one-way models are used over a large propagation distance. The single scatter approximation can be used to improve the accuracy of the beam propagation method, but its usual discrete form is not convenient for numerical implementation. We obtain an improved one-way equation as the continuous limit of the discrete single scatter approximation. Alternative discretization of this equation leads to efficient numerical implementations with the same improved accuracy.
The study of dependency of external quantum efficiency of triple-junction solar cells on measurement condition

We investigated the measurement technique for the external quantum efficiency (EQE) in triple-junction solar cell. We focused the bias voltage dependence of the EQE signal and the intensity of the incident light to the upper layer. The voltage dependence exhibited several patterns with the quantity of the leak current of the Ge-bottom cell. On the irradiated cells by the low energy proton, the bottom EQE was affected since the quantity of the photocurrent. In addition we tried to introduce the LED bias light method to estimate the effect of the photoluminescence.
Dynamic Scaling of Manipulator Trajectories

A fundamental time-scaling property of manipulator dynamics has been identified that allows modification of movement speed without complete dynamics recalculation. By exploiting this property, it can be determined whether a planned trajectory is dynamically realizable given actuator torque limits, and if not, how to modify the trajectory to bring it within dynamic and actuating constraints.