Miracle-dz/UniFAR-FTUs huggingface dataset:
Glucuronidase phenotypes of inbred mouse strains.

M A M M A L I A N ,&glucuronidase has been relatively well characterized with regard to such parameters as substrate specificity, tissue levels, pH dependence, intracellular localization, and protein structure. For a recent review the reader may consult LEVVY and CONCHIE (1966). Although this information failed to elucidate the physiolcigical role of glucuronidase, it has provided a convenient tool for the study of biochemical genetics in mammalian systems. I n one of the earliest reports of a biochemical variant in higher organisms, MORROW, GREENSPAN, and CARROLL (1949, 1950) described two closely related inbred mouse strains (Mus musculus) that showed only one tenth the liver glucuronidase activity of six other lines of inbred mice. Subsequently, from an extensive genetic study, LAW, MORROW, and GREENSPAN (1 952) concluded that a single recessive allele was responsible for this difference. The locus involved is presumed to be the structural gene for glucuronidase since mutants produce a physically altered enzyme (PAIGEN 1961a ) . Genetically it is closely linked to the retinal degeneraation gene (PAIGEN and NOELL 1961) and recently has been identified as part of linkage group XVII ( SIIIMAN and GREEN 1965). The low glucuronidase phenotype is the consequence of both a generalized decrease in enzyme activity and an altered time course of glucuronidase accumulation during post-natal development (PAIGEN 1961 b). The formation of a structurally altered enzyme protein also influences the intracellular localization of the enzyme. In the hepatic cells of normal animals the enzyme is present in approximately equal amounts in the lysosomes and the membranes of the ergastoplasm, while in the structural gene mutant the residual activity is preferentially located in lysosomes. The present study reports an attempt to find additional variants of glucuronidase which might be useful in the analysis of this enzyme in particular and, hopefully, the general problem of gene expression in higher organisms. For this purpose the glucuronidase phenotypes of a large number of inbred strains of the house mouse have been studied. Inbred mice were chosen as the subjects for several reasons: (1 ) a large number of inbred strains of independent origins exist, thus providing the necessary genetic diversity among which variants could be expected to occur; (2) if a new variant is discovered, a genetically uniform stock is immediately available; ( 3 ) mice are large enough 1.0 provide adequate quantities of tissue for biochemical
A Calculus of Secure Mobile Computations ( Preliminary Report )

The seal-calculus is a distributed process calculus in which locations and movement of computational entities are explicit. The calculus is targeted at secure distributed applications over large scale open networks such as the Internet. Security is addressed by the addition of a ne-grain access control mechanism. This paper motivates our design choices, presents the syntax and reduction semantics of the calculus, and demonstrates its expressiveness by examples focused on security and management of large distributed systems.
Linear artificial muscle actuator based on synthetic elastomer

In this paper we present a new artificial muscle actuator for rectilinear motion made of synthetic elastomer, which is mainly focused on the robotic applications. Previously, we have developed a new material for actuating means, named "synthetic elastomer". Synthetic elastomer allows their material properties such as mechanical as well as electrical properties to be adjusted according to the requirements. Using the synthetic elastomers made of the recipe adjusted for the robotic application, a new design of the artificial muscle actuator, called multi stacked actuator is proposed. The actuator is comprised of multiple stacks of synthetic elastomer coated with compliant electrodes and connecting disks. This unique design enables its linear actuation with the large strain of active length as well as large force. Experimental works are conducted and the effectiveness of the actuator is validated.
nfi, the gene for endonuclease V in Escherichia coli K-12

Endonuclease V is specific for single-stranded DNA or for duplex DNA that contains uracil or that is damaged by a variety of agents (B. Demple and S. Linn, J. Biol. Chem. 257:2848-2855, 1982). Thus, it may be a versatile DNA repair enzyme. The protein was purified to apparent homogeneity, and from its N-terminal sequence, its gene, nfi, was identified. nfi is immediately downstream of hemE, at kb 4208 (90.4 min) on the current chromosomal map of Escherichia coli K-12. This region was cloned, and plasmid insertion and deletion mutants were used to study its molecular organization. Although nfi is the third of four closely spaced, codirectional genes, it is expressed independently.
RowClone: Fast and energy-efficient in-DRAM bulk data copy and initialization

Several system-level operations trigger bulk data copy or initialization. Even though these bulk data operations do not require any computation, current systems transfer a large quantity of data back and forth on the memory channel to perform such operations. As a result, bulk data operations consume high latency, bandwidth, and energy — degrading both system performance and energy efficiency. In this work, we propose RowClone, a new and simple mechanism to perform bulk copy and initialization completely within DRAM — eliminating the need to transfer any data over the memory channel to perform such operations. Our key observation is that DRAM can internally and efficiently transfer a large quantity of data (multiple KBs) between a row of DRAM cells and the associated row buffer. Based on this, our primary mechanism can quickly copy an entire row of data from a source row to a destination row by first copying the data from the source row to the row buffer and then from the row buffer to the destination row, via two back-to-back activate commands. This mechanism, which we call the Fast Parallel Mode of RowClone, reduces the latency and energy consumption of a 4KB bulk copy operation by 11.6× and 74.4×, respectively, and a 4KB bulk zeroing operation by 6.0× and 41.5×, respectively. To efficiently copy data between rows that do not share a row buffer, we propose a second mode of RowClone, the Pipelined Serial Mode, which uses the shared internal bus of a DRAM chip to quickly copy data between two banks. RowClone requires only a 0.01% increase in DRAM chip area. We quantitatively evaluate the benefits of RowClone by focusing on fork, one of the frequently invoked system calls, and five other copy and initialization intensive applications. Our results show that RowClone can significantly improve both single-core and multi-core system performance, while also significantly reducing main memory bandwidth and energy consumption.
Large rotation FE transient analysis of piezolaminated thin-walled smart structures

A geometrically nonlinear large rotation shell theory is proposed for dynamic finite element (FE) analysis of piezoelectric integrated thin-walled smart structures. The large rotation theory, which has six independent kinematic parameters but expressed by five nodal degrees of freedom (DOFs), is based on first-order shear deformation (FOSD) hypothesis. The two-dimensional (2D) FE model is constructed using eight-node quadrilateral shell elements with five mechanical DOFs per node and one electrical DOF per piezoelectric material layer with linear constitutive equations. The linear and nonlinear dynamic responses are determined by the central difference algorithm (CDA) and the Newmark method. The results are compared with those obtained by simplified nonlinear theories, as well as those reported in the literature. It is shown that the present large rotation theory yields considerable improvement if the structures undergo large displacements and rotations.
Mutant /753-induced Immortalization of Primary Human Mammary Epithelial Cells1

Mutations of the p53 gene are the most frequent genetic lesions in breast cancer, suggesting a critical role for p53 protein in normal mam mary cell growth control. Indeed, the p53-targeting human papillomavi- rus oncogene I'd induces efficient immortalization of normal human mammary epithelial cells (MECs). To assess whether selective loss of p53 is sufficient for MIC immortalization, we introduced seven missense mutants and one single-amino acid deletion mutant (del239) of p53 into the 76N normal MEC strain. Although the missense mutants failed to immortalize MECs, the del239 mutant reproducibly immortalized these cells. The immortal cells were anchorage dependent and nontumorigenic, indicating a preneoplastic transformation, y-lrradiation of these cells failed to induce G, cell cycle arrest and did not lead to an increase in VfAFl and mdm-2 mRNA levels, demonstrating a loss of the endogenous p53 function. These results demonstrate that selective ablation of p53 function by a dominant-negative mutant is sufficient for immortalization of MECs. Availability of an immortalizing as well as several nonimmortalizing p53 mutants should help identify functions critical for cell growth control by p53 in mammary epithelial cells.
Effect of selective localization of carbon nanotubes in PA6 dispersed phase of PP/PA6 blends on the morphology evolution with time, part 1: Droplet deformation under simple shear flows

The deformation of carbon nanotube (CNT)-filled PA6 droplets in PP matrix was examined under simple shear flows. The morphology of blends with various CNT contents in PA6 were probed by FE-SEM. Based on the wetting coefficient calculations and rheological measurements, it was noted that the majority of CNTs were selectively located in the PA6 phase for concentrations up to 2 wt%. TEM micrographs evidenced the results for a sample with 0.5 wt% CNT in PA6. Optical microscopy of the blends during simple shear flows revealed the reduced deformability and breakups for filled-droplets. Such observations were ascribed to the increased viscosity ratio and gradual formation of an elastic structure within the droplets. Maffetone-Minale transient droplet deformation model was coupled with a modified capillary number to account for the developed elastic forces. It was shown that the contribution of such forces to the total shape-conserving forces could arise up to 99% in comparison with the well-known interfacial forces. These resisting forces can be so strong that for blends with CNT concentrations above 0.5 wt% in PA6 almost no deformation was observed under the applied shear stresses in this work. POLYM. ENG. SCI., 55:1504–1519, 2015. © 2014 Society of Plastics Engineers
The trouble with friendly faces: skilled performance with a supportive audience.

In 3 experiments, supportive audiences were associated with unexpected performance decrements (i.e., "choking" under pressure). On a difficult, skill-based task, participants were more likely to fail when observed by supportive audiences than when observed by nonsupportive audiences. When the criterion for success was easy, supportive audiences had no effect. With a difficult criterion, supportive audiences elicited cautious, protective strategies that were associated with poor performance: Speed decreased without improving accuracy. Despite impairments caused by supportive audiences, performers found supportive audiences more helpful and less stressful than neutral or adversarial audiences, and participants believed (wrongly) that they performed better with a supportive audience. Results suggest that people are not aware of debilitating effects of supportive audiences and may opt for emotional comfort rather than objective success.
EVALUATION OF NEW AIR PERMEABILITY TEST DEVICE FOR CONCRETE

This paper presents results of an evaluation of a device with 2 concentric chambers for nondestructive measurement of the air permeability of concrete. The Zia-Guth device is attached to the concrete surface by vacuum and measures the rate of pressure increase in the inner chamber as air flows through the outer chamber and concrete into the inner chamber. A computer program was developed to model the air flow through the concrete. The program produced a series of pressure-time curves that were combined with the experimental data to calculate the permeability constant of the concrete. The test procedure was validated by conducting an experimental program in the lab, with variables including concrete age, the use of silica fume, different water-cementitious material ratios, and curing conditions.
The VideoMob Interactive Art Installation Connecting Strangers through Inclusive Digital Crowds

VideoMob is an interactive video platform and an artwork that enables strangers visiting different installation locations to interact across time and space through a computer interface that detects their presence, video-records their actions while automatically removing the video background through computer vision, and co-situates visitors as part of the same digital environment. Through the combination of individual user videos to form a digital crowd, strangers are connected through the graphic display. Our work is inspired by the way distant people can interact with each other through technology and influenced by artists working in the realm of interactive art. We deployed VideoMob in a variety of settings, locations, and contexts to observe hundreds of visitors’ reactions. By analyzing behavioral data collected through depth cameras from our 1,068 recordings across eight venues, we studied how participants behave when given the opportunity to record their own video portrait into the artwork. We report the specific activity performed in front of the camera and the influences that existing crowds impose on new participants. Our analysis informs the integration of a series of possible novel interaction paradigms based on real-time analysis of the visitors’ behavior through specific computer vision and machine learning techniques that have the potential to increase the engagement of the artwork's visitors and to impact user experience.
Mussel‐Inspired Polydopamine Coating as a Universal Route to Hydroxyapatite Crystallization

Bone tissue is a complex biocomposite material with a variety of organic (e.g., proteins, cells) and inorganic (e.g., hydroxyapatite crystals) components hierarchically organized with nano/microscale precision. Based on the understanding of such hierarchical organization of bone tissue and its unique mechanical properties, efforts are being made to mimic these organic–inorganic hybrid biocomposites. A key factor for the successful designing of complex, hybrid biomaterials is the facilitation and control of adhesion at the interfaces, as many current synthetic biomaterials are inert, lacking interfacial bioactivity. In this regard, researchers have focused on controlling the interface by surface modifications, but the development of a simple, unified way to biofunctionalize diverse organic and inorganic materials remains a critical challenge. Here, a universal biomineralization route, called polydopamine‐assisted hydroxyapatite formation (pHAF), that can be applied to virtually any type and morphology of scaffold materials is demonstrated. Inspired by the adhesion mechanism of mussels, the pHAF method can readily integrate hydroxyapatites on ceramics, noble metals, semiconductors, and synthetic polymers, irrespective of their size and morphology (e.g., porosity and shape). Surface‐anchored catecholamine moieties in polydopamine enriches the interface with calcium ions, facilitating the formation of hydroxyapatite crystals that are aligned to the c‐axes, parallel to the polydopamine layer as observed in natural hydroxyapatites in mineralized tissues. This universal surface biomineralization can be an innovative foundation for future tissue engineering.
Formation Hybrid Method of Multilayer Biocoatings, Based on PVD Technology

Hybrid method of obtaining calcium-phosphate coatings is presented in this article. Physical and chemical, mechanical and tribological hybrid coatings research makes it possible to determine the coatings formation modes satisfying medical and technical requirements. This multilayer coating consists of an oxide underlayer formed by gas thermal oxidation and calcium phosphate layer formed by RF magnetron sputtering at a frequency of 13.56 MHz. Experiments were carried out in different modes. Calcium-phosphate coatings formed in mixture of argon and oxygen at 1:1 ratio pressure of 0.3 Pa have the best physical and chemical, mechanical and tribological properties.
(Anti)Realist Implications of a Pragmatist Dual-Process Active-Externalist Theory of Experience

Les questions relatives a l’opposition realisme/antirealisme sont abordees a la lumiere d’une philosophie pragmatiste de l’esprit. On elabore une philosophie pragmatiste de l’esprit dans les termes d’une theorie ‘externaliste-active’ de l’experience vue comme double processus. Cette theorie pose en principe deux types d’experience tels que la ‘mentalite’ (en tant que capacite a penser, emettre des hypotheses, formuler des theories, raisonner, deliberer) constitue l’un des deux types d’experience. La correspondance formelle de la theorie avec les faits est caracterisee en termes de correspondance fonctionnelle entre ces deux types d’experience. On discute alors les aspects realistes et constructivistes de cette conception. L’externalisme-actif garantit une sorte de realisme ecologique, qui permet a la theorie d’eviter le constructivisme radical ou l’irrealisme.
Effect of oxidative stress on protein thiols in the blue mussel Mytilus edulis: Proteomic identification of target proteins

Protein thiols are targets of oxidative stress. Their modification was analysed in gill extracts of the mussel Mytilus edulis, exposed to menadione. Diagonal gel electrophoresis revealed two clusters of carbonylated proteins involved in interchain disulphide linkages. Immunoblotting identified these as being associated with protein disulphide isomerase (PDI) and actin and this was confirmed by immunoprecipitation. Protein free thiols (–SH) were identified in 2‐DE separations by labelling with 5‐iodoacetamidofluorescein (IAF). Cysteines involved in disulphide bridges were identified by blocking free –SH with N‐ethylmaleimide, reducing disulphides with DTT and IAF labelling. Several protein spots containing free thiols disappeared on exposure to menadione. Conversely, new protein spots containing disulphides appeared in response to menadione which may be protective against oxidative stress. In‐gel tryptic digestion followed by LC/MS‐MS and database searching identified some of the free thiol targets: PDI; hsp gp96; calreticulin; heavy metal binding protein. Tubulin, PDI, enolase and gelsolin contained new disulphide bridges in response to menadione. Our findings indicate a protein level response to oxidative stress principally involving PDI, chaperone‐like and cytoskeletal proteins. Since many environmental pollutants cause oxidative stress, studies on PDI and structural proteins may be particularly relevant to understanding toxicity in this popular sentinel species.
Detecting Event-Related Links and Sentiments from Social Media Texts

Nowadays, the importance of Social Media is constantly growing, as people often use such platforms to share mainstream media news and comment on the events that they relate to. As such, people no loger remain mere spectators to the events that happen in the world, but become part of them, commenting on their developments and the entities involved, sharing their opinions and distributing related content. This paper describes a system that links the main events detected from clusters of newspaper articles to tweets related to them, detects complementary information sources from the links they contain and subsequently applies sentiment analysis to classify them into positive, negative and neutral. In this manner, readers can follow the main events happening in the world, both from the perspective of mainstream as well as social media and the public’s perception on them. This system will be part of the EMM media monitoring framework working live and it will be demonstrated using Google Earth.
Combining Image Features, Case Descriptions and UMLS Concepts to Improve Retrieval of Medical Images

This paper evaluates a system, UBMedTIRS, for retrieval of medical images. The system uses a combination of image and text features as well as mapping of free text to UMLS concepts. UBMedTIRS combines three publicly available tools: a content-based image retrieval system (GIFT), a text retrieval system (SMART), and a tool for mapping free text to UMLS concepts (MetaMap). The system is evaluated using the ImageCLEFmed 2005 collection that contains approximately 50,000 medical images with associated text descriptions in English, French and German. Our experimental results indicate that the proposed approach yields significant improvements in retrieval performance. Our system performs 156% above the GIFT system and 42% above the text retrieval system.
Antibacterial Properties of the Mammalian L-Amino Acid Oxidase IL4I1

L-amino acid oxidases (LAAO) are flavoproteins that catalyze the oxidative deamination of L-amino acids to a keto-acid along with the production of H2O2 and ammonia. Interleukin 4 induced gene 1 (IL4I1) is a secreted LAAO expressed by macrophages and dendritic cells stimulated by microbial derived products or interferons, which is endowed with immunoregulatory properties. It is the first LAAO described in mammalian innate immune cells. In this work, we show that this enzyme blocks the in vitro and in vivo growth of Gram negative and Gram positive bacteria. This antibiotic effect is primarily mediated by H2O2 production but is amplified by basification of the medium due to the accumulation of ammonia. The depletion of phenylalanine (the primary amino acid catabolized by IL4I1) may also participate in the in vivo inhibition of staphylococci growth. Thus, IL4I1 plays a distinct role compared to other antibacterial enzymes produced by mononuclear phagocytes.
Using collider event topology in the search for the six-jet decay of top quark-antiquark pairs

The authors investigate the use of the event topology as a tool in the search for the six-jet decay of top-pair production in proton-antiproton collisions at 1.8 TeV. Modified-Fox-Wolfram shape variables, {cflx H}{sub {ell}}, are employed to help distinguish the top-pair signal from the ordinary QCD multi-jet background. The {cflx h}{sub {ell}}`s can be constructed directly from the calorimeter cells or from jets. Events are required to lie in a region of {cflx H}{sub {ell}}-space defined by L{sub {ell}} < {cflx h}{sub {ell}} < R{sub {ell}} for {ell} = 1, . , 6, where the Left, L{sub {ell}}, and right, R{sub {ell}}, cuts are determined by a genetic algorithm (GA) procedure to maximize the signal over the square root of the background. They are able to reduce the background over the signal to less than a factor of 100 using purely topological methods without using jet multiplicity cuts and without the aid of b-quark tagging.