Miracle-dz/UniFAR-FTUs huggingface dataset:
A repetitive elements perspective in Polycomb epigenetics

Repetitive elements comprise over two-thirds of the human genome. For a long time, these elements have received little attention since they were considered non-functional. On the contrary, recent evidence indicates that they play central roles in genome integrity, gene expression, and disease. Indeed, repeats display meiotic instability associated with disease and are located within common fragile sites, which are hotspots of chromosome re-arrangements in tumors. Moreover, a variety of diseases have been associated with aberrant transcription of repetitive elements. Overall this indicates that appropriate regulation of repetitive elements’ activity is fundamental. Polycomb group (PcG) proteins are epigenetic regulators that are essential for the normal development of multicellular organisms. Mammalian PcG proteins are involved in fundamental processes, such as cellular memory, cell proliferation, genomic imprinting, X-inactivation, and cancer development. PcG proteins can convey their activity through long-distance interactions also on different chromosomes. This indicates that the 3D organization of PcG proteins contributes significantly to their function. However, it is still unclear how these complex mechanisms are orchestrated and which role PcG proteins play in the multi-level organization of gene regulation. Intriguingly, the greatest proportion of Polycomb-mediated chromatin modifications is located in genomic repeats and it has been suggested that they could provide a binding platform for Polycomb proteins. Here, these lines of evidence are woven together to discuss how repetitive elements could contribute to chromatin organization in the 3D nuclear space.
Perceived person-organization fit and turnover intention in medical centers: The mediating roles of person-group fit and person-job fit perceptions

Purpose The purpose of the paper is to fill gaps in the existing fit and turnover intention (TI) literature by investigating a more comprehensive model, in which TI is proposed to be influenced by the interplays of three multidimensional types of fit including, person-organization (P-O) fit, person-group (P-G) fit, and person-job (P-J) fit. Design/methodology/approach Participants were selected from different specializations within Mansoura University medical centers, where each medical center was represented proportionately within the sample. Data were collected using self-administered questionnaires. Questionnaires were provided to 850 employees who agreed to participate. Of the 850 questionnaires distributed, 385 were valid and complete (n=385). Partial least squares analysis was utilized for the analyses. Findings Results showed that P-O fit, P-G fit, and P-J fit were positively related to each other and negatively related to TI. Furthermore, the negative relationship between P-O fit and TI is partially mediated by P-G fit and P-J fit. Originality/value The present study simultaneously examines the multidimensional effects of different fit perceptions on TI. In doing so, we identify which of the fit perspectives influence TI more intensely. Moreover, the authors advance current insights by investigating the mediating roles of P-G fit and P-J fit in the relationship between P-O fit and TI.
MULTEXT-East Resources for Serbian

MULTEXT-East is a multilingual dataset for language engineering research and development. This standardised and linked set of resources covers a large number of mainly Central and Eastern European languages and includes the EAGLES-based morphosyntactic specifications, defining the features that describe word-level syntactic annotations; medium scale morphosyntactic lexica; and annotated parallel, comparable, and speech corpora. The most important component is the linguistically annotated corpus consisting of Orwell's novel "1984" in the English original and translations. MULTEXT-East has already seen several editions, with the latest one being Version 3, where the most important addition has been that of Serbian language resources. The paper presents MULTEXT-East Version 3 with special emphasis on the Serbian components, namely the structurally annotated "1984", the morphosyntactic specifications, the morphosyntactic lexicon and the linguistically annotated "1984". The complete dataset, unique in terms of languages and the wealth of encoding, is extensively documented, and freely available for research purposes.
Integrated LPV control for underactuated ship linear track keeping and main diesel engine

Based on integrated control for underactuated ship linear track keeping and main diesel engine, A new integrated control arithmetic designed by the linear parameter varying (LPV) system control theory and the closed system poles assigned via state feedback is proposed. The ship motion equations of the MMG model is translated into LPV systems with ship speed as the scheduling parameter. The main engine speed control equation of the MMG model is translated into a LPV system through main engine speed and advance coefficient of propeller as the scheduling parameters. By using the closed system poles assigned via state feedback and polytopic gain scheduled design method with linear matrix inequalities technique, the controller of straight line trajectory and the controller of main engine speed of the underactuated ship are designed. Simulation results are presented to validate the effectiveness of integrated LPV control.
Architectural impact on performance of a multilevel database system

Since protection and assurance are the primary concerns in multilevel secure (MLS) databases, performance has often been sacrificed in some known MLS database approaches. Motivated by performance concerns, a replicated architecture approach which uses a physically distinct back-end database management system for each security level is being investigated. This is a report on the behavior and performance issues for the replicated architecture approach. Especially, we compare the performance of the SINTRA (Secure INformation Through Replicated Architecture) MLS database system to that of a typical conventional (non-secure, single-level) database system. After observing the performance bottlenecks for SINTRA, we present solutions that can alleviate them. <<ETX>>
Monitoring Student Activity in Collaborative Software Development

This paper presents data analysis from a course on Software Engineering in an effort to identify metrics and techniques that would allow instructor to act proactively and identify patterns of low engagement and inefficient peer collaboration. Over the last two terms, 106 students in their second year of studies formed 20 groups and worked collaboratively to develop video games. Throughout the lab, students have to use a variety of tools for managing and developing their projects, such as software version control, static analysis tools, wikis, mailing lists, etc. The students are also supported by weekly meetings with teaching assistants and instructors regarding group progress, code quality, and management issues. Through these meetings and their interactions with the software tools, students leave a detailed trace of data related to their individual engagement and their collaboration behavior in their groups. The paper provides discussion on the different source of data that can be monitored, and present preliminary results on how these data can be used to analyze students' activity.
Logic programming with the World-Wide Web

We introduce Logic Web, an integration of structured logic programming and the World-Wide Web. We show how LogicWeb enables programmable behaviour and state to be incorporated into Web pages, allowing them to be viewed as modules or objects with state. LogicWeb renders a Web page as a live information entity, able to determine its own response to user queries, and modify the behaviour of hyperlinks. This amalgamation of logic and the Web makes it possible to reason with Web pages, state relationships between pages, and dynamically generate pages. A prototype system is described, which extends Mosaic with LogicWeb capabilities using the Common Client Interface. In addition, we outline a client-based search tool written with LogicWeb and compare it with an existing package.
Term Extraction Using Co-occurrence in Abstract and First Claim for Patent Analysis

Patent information analysis need to extract patent terms from a vast amount of patent records rapidly and accurately. This paper proposes a patent term extraction method using co-occurrence in abstract and first claim sections of patent records. The research is carried out in three steps. In experiment 1, our proposed method's F1 is 34.8% and higher than that of KEA with 21.0%. This demonstrates the good performance of our proposed method from a standard point of view. In experiment 2, our proposed method selects only 10,866 qualified terms from 28,044 candidate strings, with the selection percentage of 38.75%. There are 96.8% of total patent claims that contain the candidate terms at the same time. This illustrates the advantage of the proposed method in both eliminating unqualified candidates and providing a good coverage of patent texts from an actual application perspective.
Sensitive VLBI Observations of the z QSO BRI 1202−0725

We present sensitive phase-referenced VLBI observations of the radio continuum emission from the z = 4.7 double source BRI 1202-0725. The observations were carried out at 1425 MHz using the Very Long Baseline Array, the phased Very Large Array, and the Green Bank Telescope. Our sensitive VLBI images of BRI 1202-0725 at 0. ″25 × 0. ″14 resolution show a continuum structure in each of its two components. Fitting Gaussian models to these continuum structures yields total flux densities of 315 ± 38 and 250 ± 39 μJy for the northern and the southern components, respectively. The estimated intrinsic brightness temperatures of these continuum structures are ∼2 × 104 K. Neither component is detected at the full VLBI resolution (29 × 7 mas2), with a 4 σ point-source upper limit of 40 μJy beam-1, or an upper limit to the intrinsic brightness temperature of 6.7 × 105 K. The highest angular resolution with at least a 4 σ detection is ∼85 mas. At this resolution, the images reveal a single continuum feature in the northern component of BRI 1202-0725 and two continuum features in the southern component, separated by 320 mas. This is similar to the structures seen in the high-resolution images of the CO emission. The extent of the observed continuum sources at 1.4 GHz and the derived brightness temperatures are consistent with nuclear starbursts. Moreover, the absence of any compact high brightness temperature source suggests that there is no radio-loud active galactic nucleus in BRI 1202-0725.
Adaptive Collision Avoidance through Implicit Acknowledgments in WSNs

The large number of nodes, typical of many sensor network deployments, and the well-known hidden terminal problem make collision avoidance an essential goal for the actual employment of WSN technology. Collision avoidance is traditionally dealt with at the MAC Layer and plenty of different solutions have been proposed, which however have encountered limited diffusion because of their incompatibility with commonly available devices.In this paper we propose an approach to collision avoidance which is designed to work over a standard MAC Layer, namely the IEEE 802.15. 4 MAC, and is based on application-controlled delays of packet transmission times. The proposed scheme is simple, decentralized and scalable. We present two variants of the algorithm and we evaluate our work through simulations. Discussed results show that our scheme provides a considerable boost of performance in IEEE 802.15. 4 tree-based networks, effectively addressing the hidden terminal problem and keeping radio utilization efficient.
Implementing parallel shortest-paths algorithms

We have implemented two parallel versions of the Bellman-Ford-Moore algorithm for the single-source shortest-paths problem. Our software is written in C and runs on the CM-5 parallel supercomputer using CMMD communication primitives. We have compared the performance of our parallel programs with a serial implementation of the Bellman-Ford-Moore algorithm developed by Cherkassky, Goldberg and Radzik. In our experiments we used 50 randomly generated graphs with up to 2 15 vertices and 2 21 edges. Our fastest parallel program always achieved speedups greater than 1 when the average degree of the graphs exceeded 2 5 for the smaller and 2 3 for the larger inputs in our test suite. On dense graphs, we achieved speedups of up to 7.8 on a CM-5 with 32 processors.
Effect of childhood adversity experiences, psychological distress, and resilience on depressive symptoms among Indonesian university students

ABSTRACT This study examined the role of childhood adversity experiences, psychological distress and resilience on depressive symptoms. The sample consisted of 443 Indonesian university students. Participants’ age range from 17 to 21 (M = 18.60, SD = 0.61). Adverse Childhood Experiences (ACEs) Questionnaire, General Health Questionnaire-12 (GHQ-12), Connor-Davidson Resilience Scale (CD-RISC), and Beck Depression Inventory-II (BDI-II) were used to guide data collection. Path analysis results revealed the direct relationship between the childhood traumas with depressive symptoms and, had no direct relationship on resilience. In addition, resilience partially mediates the relationship between adolescents’ psychological distress and depressive symptoms but not to childhood trauma and depressive symptoms. These results indicate the importance of the influence of resilience and the importance of the development of university based programs aimed to promote resilience among Indonesian university students.
New findings about iron oxide nanoparticles and their different effects on murine primary brain cells

The physicochemical properties of superparamagnetic iron oxide nanoparticles (SPIOs) enable their application in the diagnostics and therapy of central nervous system diseases. However, since crucial information regarding side effects of particle–cell interactions within the central nervous system is still lacking, we investigated the influence of novel very small iron oxide particles or the clinically approved ferucarbotran or ferumoxytol on the vitality and morphology of brain cells. We exposed primary cell cultures of microglia and hippocampal neurons, as well as neuron–glia cocultures to varying concentrations of SPIOs for 6 and/or 24 hours, respectively. Here, we show that SPIO accumulation by microglia and subsequent morphological alterations strongly depend on the respective nanoparticle type. Microglial viability was severely compromised by high SPIO concentrations, except in the case of ferumoxytol. While ferumoxytol did not cause immediate microglial death, it induced severe morphological alterations and increased degeneration of primary neurons. Additionally, primary neurons clearly degenerated after very small iron oxide particle and ferucarbotran exposure. In neuron–glia cocultures, SPIOs rather stimulated the outgrowth of neuronal processes in a concentration- and particle-dependent manner. We conclude that the influence of SPIOs on brain cells not only depends on the particle type but also on the physiological system they are applied to.
Dispersal by rodent caching increases seed survival in multiple ways in canopy‐fire ecosystems

Abstract Seed‐caching rodents have long been seen as important actors in dispersal ecology. Here, we focus on the interactions with plants in a fire‐disturbance community, specifically Arctostaphylos species (Ericaceae) in California chaparral. Although mutualistic relationships between caching rodents and plants are well studied, little is known how this type of relationship functions in a disturbance‐driven system, and more specifically to systems shaped by fire disturbance. By burying seeds in the soil, rodents inadvertently improve the probability of seed surviving high temperatures produced by fire. We test two aspects of vertical dispersal, depth of seed and multiple seeds in caches as two important dimensions of rodent‐caching behavior. We used a laboratory experimental approach to test seed survival under different heating conditions and seed bank structures. Creating a synthetic soil seed bank and synthetic fire/heating in the laboratory allowed us to have control over surface heating, depth of seed in the soil, and seed cache size. We compared the viability of Arctostaphylos viscida seeds from different treatment groups determined by these factors and found that, as expected, seeds slightly deeper in the soil had substantial increased chances of survival during a heating event. A key result was that some seeds within a cache in shallow soil could survive fire even at a depth with a killing heat pulse compared to isolated seeds; temperature measurements indicated lower temperatures immediately below caches compared to the same depth in adjacent soil. These results suggest seed caching by rodents increases seed survival during fire events in two ways, that caches disrupt heat flow or that caches are buried below the heat pulse kill zone. The context of natural disturbance drives the significance of this mutualism and further expands theory regarding mutualisms into the domain of disturbance‐driven systems.
Performance Evaluation of Admission Control and Adaptive Modulation in OFDMA WiMax Systems

In this paper, we study the performance of multi-cell OFDMA WiMAX systems, in both downlink and uplink. We calculate analytically the number of collisions when the number of users in each cell is known. We then calculate the QoS indicators (e.g., blocking rates, download time and bit error rates) taking into account the physical layer conditions (modulation, propagation and MIMO), the MAC layer techniques (HARQ and radio resource management algorithms) and the traffic characteristics, in a cross-layer approach. We finally evaluate the impact of using adaptive modulation and coding on the overall performance of the system. This analysis allows us to calculate the Erlang capacity of a WiMAX system. Our numerical applications then show how to choose the best admission control and modulation schemes that extend the Erlang capacity region.
ScatterBlogs2: Real-Time Monitoring of Microblog Messages through User-Guided Filtering

The number of microblog posts published daily has reached a level that hampers the effective retrieval of relevant messages, and the amount of information conveyed through services such as Twitter is still increasing. Analysts require new methods for monitoring their topic of interest, dealing with the data volume and its dynamic nature. It is of particular importance to provide situational awareness for decision making in time-critical tasks. Current tools for monitoring microblogs typically filter messages based on user-defined keyword queries and metadata restrictions. Used on their own, such methods can have drawbacks with respect to filter accuracy and adaptability to changes in trends and topic structure. We suggest ScatterBlogs2, a new approach to let analysts build task-tailored message filters in an interactive and visual manner based on recorded messages of well-understood previous events. These message filters include supervised classification and query creation backed by the statistical distribution of terms and their co-occurrences. The created filter methods can be orchestrated and adapted afterwards for interactive, visual real-time monitoring and analysis of microblog feeds. We demonstrate the feasibility of our approach for analyzing the Twitter stream in emergency management scenarios.
Feature-aligned T-meshes

High-order and regularly sampled surface representations are more efficient and compact than general meshes and considerably simplify many geometric modeling and processing algorithms. A number of recent algorithms for conversion of arbitrary meshes to regularly sampled form (typically quadrangulation) aim to align the resulting mesh with feature lines of the geometry. While resulting in a substantial improvement in mesh quality, feature alignment makes it difficult to obtain coarse regular patch partitions of the mesh. In this paper, we propose an approach to constructing patch layouts consisting of small numbers of quadrilateral patches while maintaining good feature alignment. To achieve this, we use quadrilateral T-meshes, for which the intersection of two faces may not be the whole edge or vertex, but a part of an edge. T-meshes offer more flexibility for reduction of the number of patches and vertices in a base domain while maintaining alignment with geometric features. At the same time, T-meshes retain many desirable features of quadrangulations, allowing construction of high-order representations, easy packing of regularly sampled geometric data into textures, as well as supporting different types of discretizations for physical simulation.
Iron Status and Reproduction in US Women: National Health and Nutrition Examination Survey, 1999-2006

Women experience significant changes in iron status throughout their reproductive lifespans. While this is evident in regions with high rates of malnutrition and infectious disease, the extent of reproductive-related changes is less well known in countries with low rates of iron deficiency anemia, such as the United States. The goal of this study is determine the relationship between women's reproductive variables (pregnancy, parity, currently breastfeeding, regular menstruation, hormonal contraceptive use, and age at menarche) and iron status (hemoglobin, ferritin, transferrin receptor, and % transferrin saturation) using an anthropological framework for interpreting the results. Data from women aged 18–49 were taken from the 1999–2006 US NHANES, a nationally representative cross-sectional sample of US women. Using multiple imputation and complex survey statistics, women's reproductive variables were regressed against indicators of iron status. Pregnant women had significantly poorer iron status, by most indicators, than non-pregnant women. All biomarkers demonstrated significantly lower iron levels with increasing parity. Women who were having regular periods had iron indicators that suggested decreased iron levels, while women who used hormonal contraceptives had iron indicators that suggested increased iron levels. Despite relatively good iron status and widespread availability of iron-rich foods in the US, women still exhibit patterns of iron depletion across several reproductive variables of interest. These results contribute to an ecological approach to iron status that seeks to understand variation in iron status, with the hopes that appropriate, population-specific recommendations can be developed to improve women's health.