Miracle-dz/UniFAR-FTUs huggingface dataset:
Genomic-based biomarkers of drug-induced nephrotoxicity

Typical drug development timelines are 10 15years, with high attrition rates that make it difficult for companies to sustain productive pipelines. Investigational and discovery toxicology are novel and revolutionary extensions of the field of general toxicology, which has been created to fulfil the growing need for generating higher throughput, and integrative and predictive toxicological information, in an effort to reduce attrition. Included in this new paradigm is transcript profiling, and recent innovations have led some to speculate that genomics would help revolutionise drug development, as more better predictive biomarkers of organ damage would be identified. The kidney has been a focus of toxicogenomics investigations, and candidate genomic-based biomarkers of renal damage have been identified for rodent as well as nonhuman primate models of nephrotoxicity. This review highlights published results that have led to the preliminary identification of candidate genomic-based markers of nephrotoxicity and provides insight into the future of toxicogenomics.
Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Fast and Reliable Identification of Clinical Yeast Isolates

ABSTRACT The clinical impact of severe infections with yeasts and yeast-like fungi has increased, especially in immunocompromised hosts. In recent years, new antifungal agents with different and partially species-specific activity patterns have become available. Therefore, rapid and reliable species identification is essential for antifungal treatment; however, conventional biochemical methods are time-consuming and require considerable expertise. We evaluated matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) for the rapid routine identification of clinical yeast isolates. A total of 18 type collection strains and 267 recent clinical isolates of Candida (n = 250), Cryptococcus, Saccharomyces, Trichosporon, Geotrichum, Pichia, and Blastoschizomyces spp. were identified by MALDI-TOF MS. The results were compared with those obtained by conventional phenotyping and biochemical tests, including the API ID 32C system (bioMérieux, Nürtingen, Germany). Starting with cells from single colonies, accurate species identification by MALDI-TOF MS was achieved for 247 of the clinical isolates (92.5%). The remaining 20 isolates required complementation of the reference database with spectra for the appropriate reference strains which were obtained from type culture collections or identified by 26S rRNA gene sequencing. The absence of a suitable reference strain from the MALDI-TOF MS database was clearly indicated by log(score) values too low for the respective clinical isolates; i.e., no false-positive identifications occurred. After complementation of the database, all isolates were unambiguously identified. The established API ID 32C biochemical diagnostic system identified 244 isolates in the first round. Overall, MALDI-TOF MS proved a most rapid and reliable tool for the identification of yeasts and yeast-like fungi, with the method providing a combination of the lowest expenditure of consumables, easy interpretation of results, and a fast turnaround time.
Oxidation of protoporphyrinogen in the obligate anaerobe Desulfovibrio gigas

The anaerobic oxidation of protoporphyrinogen to protoporphyrin was demonstrated in extracts of Desulfovibrio gigas. Protoporphyrin formation occurred in the presence of nitrite, hydroxylamine, sulfite, thiosulfate, ATP plus sulfate, NAD+, NADP+, flavin adenine dinucleotide, flavin mononucleotide, fumarate, 2,6-dichlorophenol-indophenol, methyl viologen, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. With dialyzed cell extracts, highest activities were observed with sulfite, NAD+, and NADP+ as electron acceptors. The enzyme for protoporphyrinogen oxidation was localized in the membrane of D. gigas and displayed optimal activity at pH 7.3 and 28 degrees C.
Enhancing the performances of H-plane SIW horn antennas

The performances of SIW horns antennas diminish significantly when the substrate thickness is much smaller than the free space wavelength λ<;sub>0<;/sub>. Specifically, the mismatch between the antenna aperture and the air yields to unwanted back radiation and poor matching. This paper presents a fully printed structure etched after the horn aperture to simultaneously solve these two problems. Models based on transmission line and array theory have been developed to analyse and synthesize this new type of structure. They provide simple design rules to characterize the SIW horn geometry and to reasonably predict its electromagnetic performances. In addition, the horn profile is further optimized by reducing its dimensions needed for a given directivity. The presented concepts are verified by manufacturing a prototype in a substrate thinner than λ0/10 working between 14.2-15.4 GHz. Its excellent performances (|S11| <; -10 dB and FTBR > 15 dB) together with simple and low-cost construction opens the door to the use of SIW horns in many other applications.
Single-view 3 D reconstruction of basketball scenes

The introduction of tracking technology in sports, such as the SportVU system in the NBA, has provided profession analysts data with huge potential for advanced analysis. This data is unavailable to the general public due to the high cost required for installation and maintanence of the equipment. We propose a robust algorithm for camera calibration of NBA basketball scenes using a single image derived from television broadcast. We were able to achieve a high degree of accuracy of reprojected points for a large percentage of images seen from the video. This robust foundation for further development into an open-source ‘SportVU’ system.
Optimizing operational amplifiers by metaheuristics and considering tolerance analysis

An operational tranconductance amplifier (OTA) is sized by applying multi-objective evolutionary algorithms. The OTA is designed using CMOS integrated circuit technology of 0.35 μm. From the obtained feasible solutions, a tolerance analysis is performed for each width (W) and length (L) of the MOSFETs. This analysis helps to evaluate the W/L tolerances of the transistors so that the developed optimization approach choose the solution with the best performance that has the lowest sensitivity. The selected feasible sized-design is used to implement a universal active filter, showing that the associated tolerance guarantees good performance of the OTA.
Corporate Finance, Capital Market Equilibrium, and International Tax Competition with Capital Income Taxes

International capital tax competition means the strategic use of taxes on capital and capital income by self-interested national governments in an integrated economic environment with free capital movement. It is a phenomenon whose actual or potential occurrence gives rise to substantial worry. There may be mainly three reasons for this : first, the amount and the structure of capital invested in a country play a key role for its economic standing and prospects. If tax competition induces changes in the international capital allocation, this may have severe consequences for the nations involved. Secondly, capital (esp. financial capital) is internationally highly mobile and reacts very sensitively to its fiscal treatment. Hence, changes in tax rates are likely to be followed by noticeable changes in the capital allocation. This distinguishes capital from, e.g., labour whose relatively low international mobility makes labour income a very inelastic tax base. Thirdly, in all major industrialized countries taxes on capital income form an important source of governments' revenues such that tax competition in this area will also affect other policy areas and thus the fiscal systems as a whole. The strategic interaction with taxes on capital income is a tricky game which is of crucial importance for the governments engaged in it. Economic
Identification of a New Mutation (L46P) in the Human NOG Gene in an Italian Patient with Symphalangism Syndrome

Proximal symphalangism (SYM1) is a joint morphogenesis disorder characterized by stapes ankylosis, proximal interphalangeal joint fusion, skeletal anomalies and conductive hearing loss. Noggin is a bone morphogenetic protein (BMP) antagonist essential for normal bone and joint development in humans and mice. Autosomal dominant mutations have been described in the NOG gene, encoding the noggin protein. We analyzed an Italian sporadic patient with SYM1 due to a novel NOG mutation (L46P) based on a c.137T>C transition. A different pathogenic mutation in the same codon (L46D) has been previously described in an in vivo chicken model. An in silico model shows a decreased binding affinity between noggin and BMP7 for both L46D and L46P compared to the wild type. Therefore, this codon should play an important role in BMP7 binding activity of the noggin protein and consequently to the joint morphogenesis.
Reasons for developing or exiting business in the primary sector - A study of milk farmers in central-west Sweden

The aim of this research was to study empirically what characterize farms and farmers that choose to develop the milk production at their farms. The background was that several farms have exited milk production, which threatens both goals about rural development and also the activities of the dairies. Based on survey data from 313 milk producing farms in central-west Sweden and structural equation analysis, it was concluded that farms that are accustomed to changes will develop their milk production further. The results also showed that farms which are more dependent on their milk production are more likely to develop their milk production. Furthermore, it was indicated that satisfactory supply of qualified labour stimulates development of milk production, as do location of the farm at a longer distance from common facilities. The results also showed that the farmers who develop their farms have more positive expectations about profitability in milk production and are also less risk averse. Finally, the results indicated that information through trade magazines and similar oneway communication channels are used by those who develop their milk production and that farmers who develop their milk production are those who take actions to evaluate their strategic decisions more seriously.
Noncovalent Complexes of an Inactive Mutant of CTX-M-9 with the Substrate Piperacillin and the Corresponding Product

ABSTRACT We determined the crystal structure of an inactive Ser70Gly mutant of CTX-M-9 in complex with the bulky penicillin piperacillin at precovalent and posthydrolytic stages in the catalytic process. The structures obtained at high resolution were compared with the corresponding structures for the small penicillin benzylpenicillin and the bulky cephalosporin cefotaxime. The findings highlight the key role of the configuration of the carbon adjacent to the acylamino group of the side chain of β-lactams in the precovalent recognition of substrates.
Study on the Information Security based on E-Commerce

With the progress of economic globalization and information technology, e-commerce also has made a fast development. Meanwhile, the information security in e-commerce industry is becoming more and more important. This paper described information security issues existing in e-commerce, and provided technology strategy and management system on how to enhance the e-commerce information security.
Open innovation : researching a new paradigm

1. Open Innovation: A New Paradigm for Understanding Industrial Innovation SECTION I: FIRMS IMPLEMENTING OPEN INNOVATION 2. New Puzzles and New Findings 3. Whither Core Competency for the Large Corporation in an Open Innovation World? 4. Open, Radical Innovation: Toward an Integrated Model in Large Established Firms 5. Patterns of Open Innovation in Open Source Software SECTION II: INSTITUTIONS GOVERNING OPEN INNOVATION 6. Does Appropriability Enable or Retard Open Innovation? 7. The Use of University Research in Firm Innovation 8. Open Standards and Intellectual Property Rights 9. The Use of Intellectual Property in Software: Implications for Open Innovation SECTION III: NETWORKS SHAPING OPEN INNOVATION 10. The Inter-organizational Context of Open Innovation 11. Knowledge Networks and the Geographic Locus of Innovation 12. Open Innovation in Systemic Innovation Contexts 13. Open Innovation in Value Networks SECTION IV: CONCLUSIONS 14. Open Innovation: A Research Agenda
The Homeboy Bias: Evidence For and Determinants Of

We document a new investor bias we call the homeboy bias. Whereas the home bias is a preference for domestic or local assets, the homeboy bias is a preference for domestic fund managers. Using the choices of mutual funds for retirement accounts of the Swedish population, and after controlling for past returns, fees, and fund styles, we find that funds offered by Swedish institutions received over 21 times more money than similar funds offered by foreign institutions. In cross-fund regressions, we show that the homeboy bias is distinct from the home bias and is not driven by economic explanations based on information asymmetries or foreign exchange risk. In cross-individual regressions, we show that the homeboy bias is strongest among financially-unsophisticated investors and that explanations for the homeboy bias may be based on behavioral preferences related to familiarity and nationalism. Thus, the homeboy bias is empirically distinct from the home bias but may have the same behavioral roots.
[Urinary stone in a Bricker's ileal conduit].

OBJECTIVES To report one case of urinary stone as a relatively frequent complications of urinary diversion using bowel loops. METHODS We perform a short bibliographic review using the case report format. RESULTS Stone formation in Bricker's type urinary diversion is secondary to various factors such as urinary stasis, bacteriuria, presence of intestinal mucus, metallic sutures, metabolic disturbances, etc. CONCLUSIONS Periodic control by radiological studies is recommended due to the high frequency of this complication in patients with urinary diversion. Treatment is usually conservative or minimally invasive, being surgery reserved for those cases in which stone extraction is not safe using other methods.
Outsourcing Transportation Services: Evidence from Mexican Maquiladora Industry

The purpose of this paper is to present evidence of the use of transportation outsourcing in the Mexican maquiladora industry. Additionally, the paper studies the decision making process that takes place in favor of choosing to outsource the transportation activity. An empirical research in the form of in depth case studies was carried out in Mexico to study and test eight propositions related to the decision to outsource transportation services. The propositions are based on literature review of agency theory and outsourcing theory. Among the finding are: there is a positive relationship between the decision to outsource transportation services and non-core activities. Additionally, the decision to outsource is favored due to cost efficiency. There is a significant relationship between uncertainty of the transportation service and the use of monitoring systems. The relevance of this study is that there is limited research on outsourcing logistics activities in Mexico.
Design of adaptive fuzzy controller for uncertain fuzzy systems with multiple time delays

In this paper, an adaptive fuzzy control scheme for fuzzy systems with multiple delayed state perturbations, time- varying uncertain parameters, and disturbances. These delayed state perturbations, uncertainties, and external disturbances in the fuzzy systems are assumed to be any uncertain bounded but unknown continuous functions. An improved adaptation law with sigma-modification is proposed to estimate such unknown bounds, and on the basis of the updated values of these unknown bounds, a continuous memoryless state feedback controller is constructed for achieving robust stability of the closed-loop system. Based on Lyapunov stability theorem, the proposed adaptive robust fuzzy controller can guarantee that the state converges asymptotically to zero in the presence of multiple delayed state perturbations, time-varying uncertain parameters, and disturbance. In addition, it is also shown that this improved adaptation law with sigma-modification can be applied to the general adaptive control problems to obtain some more exact control results. Finally, an inverted pendulum system is given to demonstrate the validity of the proposed design method.
A dual-function microstrip antenna for compass and WLAN applications

A dual-function rectangular microstrip antenna for compass and WLAN applications is presented. The proposed antenna has different polarizations and radiation patterns at two frequencies. The antenna is circularly polarized and has a broadside radiation pattern at 1.268 GHz. An omnidirectional radiation pattern is achieved at 2.44 GHz. The lower operating band of the antenna is caused by the TM10 and TM01 modes, and the upper one is due to the TM20 and TM02 modes. HFSS simulation is presented to verify the design, and it shows that the proposed antenna is suitable for both compass and WLAN applications.
Consumer-Brand Identification: Conceptualization, Antecedents and Consequences Abstract Despite the surge in interest in research on organizational identification, little attention has been paid to investigating the notion of identification in the branding context. Moreover, consumer-brand identific

Despite the surge in interest in research on organizational identification, little attention has been paid to investigating the notion of identification in the branding context. Moreover, consumer-brand identification has been conceptualized and opertionalized equally as organizational identification while ignoring both the shortcomings of organizational identification measures and the differences between the two contexts. Drawing on social identity theory and marketing literature, the authors develop a theory-derived definition of consumer-brand identification distinct from organizational identification. Additionally, the authors propose a conceptual model of the different antecedents and consequences of consumer-brand identification, including product involvement as a key moderating variable. The findings of this study would benefit the managers to gain a better understanding of the factors that are valuable for consumers, thereby increasing both in-role and extra-role behaviour.
Thin titanium oxide films obtained by RTP and by sputtering

In this paper, two methods to obtain titanium oxide (TiO2) thin films are compared. In the first method metallic titanium (Ti) is deposited by sputtering and then oxidized by rapid thermal process (RTP) in an oxygen atmosphere to form the TiO2 thin films. The second method consists in TiO2 deposition by reactive sputtering. Structural characterization of the prepared samples shows the rutile crystal structure for both films, but TiO2 thin film deposited by sputtering also presented anatase crystal structure. Capacitors were fabricated and the electrical characterization of TiO2 films realized in order to determine which method forms the best dielectric film, defined by high dielectric constant value (high-k), lower charge density (Q0/q) and flat-band voltage (VFB) around -0.9V.
Prevalence of underweight, overweight and obesity in Turkish adolescents.

BACKGROUND The aim of this study was to determine underweight, overweight and obesity prevalence in a representative sample of adolescents living in urban and rural area of central Edirne, Turkey, and to compare the 95th percentile BMI curve to the curves of other countries. MATERIAL AND METHODS Data concerning the height and weight of 989 adolescents, aged between 12 and 17 years were collected. The prevalence of underweight was defined as the percentage of adolescents below the 5th percentiles of the American adolescents' age and gender specific BMI; prevalence of overweight and obesity were based on the cut off points of the International Obesity Task Force values (excess of the 85th and 95th percentiles), respectively. RESULTS This study demonstrated that the prevalence of underweight, overweight and obesity among adolescent girls was 11.1%, 10.6% and 2.1%, respectively, while it was 14.4%, 11.3% and 1.6% for adolescent boys. In the urban area the prevalence of underweight, overweight and obesity among adolescent girls was 10.0%, 10.3% and 2.1%, while it was 14.4%, 11.6% and 1.6% for boys, respectively. In the rural area; the prevalence of underweight, overweight and obesity among adolescent girls was 15.7%, 12.4% and 2.2%, while it was 14.5%, 9.6% and 1.2% for boys, respectively. DISCUSSION Analyses of data collected during these studies support that adolescents living in the city of Edirne carry relatively lower further risk of overweight and obesity than adolescents in other countries do.
On the existence of a connected component of a graph

We study the reverse mathematics and computability of countable graph theory, obtaining the following results. The principle that every countable graph has a connected component is equivalent to $\mathsf{ACA}_0$ over $\mathsf{RCA}_0$. The problem of decomposing a countable graph into connected components is strongly Weihrauch equivalent to the problem of finding a single component, and each is equivalent to its infinite parallelization. For graphs with finitely many connected components, the existence of a connected component is either provable in $\mathsf{RCA}_0$ or is equivalent to induction for $\Sigma^0_2$ formulas, depending on the formulation of the bound on the number of components.
The Business Models for Sustainability Innovation Framework

This paper develops the business models for sustainability innovation (BMfSI) framework. It defines innovation-based business cases as the major goal of sustainable entrepreneurs and identifies their most important barriers, i.e. barriers to profiting from sustainability innovations. A common business model concept is linked to these issues, and its artificial and socially constructed nature, which makes it a multi-functional device, is discussed. Based on these theoretical foundations, the BMfSI framework integrates the main results from the underlying doctoral research project. The framework defines four basic interfaces at the intersections of the most important concepts and issues related to the idea of business models for sustainability innovation: the sustainability innovation, business case, public policy, and financing interfaces. These are connected to the literature in the respective fields and illustrated with findings from different empirical studies on the solar photovoltaic industry. On a general level, the BMfSI framework helps in structuring the emerging sustainable entrepreneurship research with a particular focus on innovation and business models.
Spin-liquid phase of the multiple-spin exchange Hamiltonian on the triangular lattice

We performed an exact diagonalization study of the spin-liquid phase of the multiple-spin exchange model on a triangular lattice. It is characterized by no N\'eel long-range order, short-ranged magnetic correlations, and a spin gap. We found no long-range order in any local order parameter we investigated (chiral, dimer, etc.) The probable asymptotic ground-state degeneracy is discussed. We argue that it could be of topological origin and that the system is probably not a chiral spin liquid. A possible relation to the Affleck-Kennedy-Lieb-Tasaki, or valence-bond solid phase is discussed.