Miracle-dz/UniFAR-FTUs huggingface dataset:
Vascular Remodeling–Associated Hypertension Leads to Left Ventricular Hypertrophy and Contractile Dysfunction in Profilin-1 Transgenic Mice

Abstract: Hypertension is a major health problem and a main risk factor for cardiovascular diseases. We have shown that overexpression of profilin-1 in blood vessels of transgenic mice generates mechanical tone and led to vascular remodeling/hypertension. However, little is known whether cardiac contractile performance in these mice is compromised. We investigated the in vivo contractile function and in vitro contractile performance using isolated papillary muscles from both right ventricle and left ventricle of profilin-1 mice at older age. Our results showed mild left ventricular hypertrophy and moderate systolic dysfunction in profilin-1 mice as evident by increased heart/body weight ratio and echocardiography analysis. Under near physiological conditions, right ventricle papillary muscles of profilin-1 mice maintained their peak isometric active developed tension, and the rate of force development over the entire frequency range of 4–14 Hz. Positive inotropic responses to increasing Ca2+ and &bgr;-adrenergic stimulation were also maintained. Conversely, left ventricular papillary muscles of profilin-1 mice exhibited depressed peak isometric, peak isometric active developed tension and rate of force development, and depressed positive inotropic responses to increasing Ca2+ and &bgr;-adrenergic stimulation. We here provide functional evidence that a significant contractile dysfunction in profilin-1 mice exists. Targeting vascular profilin-1 signaling could represent a promising therapeutic approach in hypertensive patients.
Nonserial dynamic programming with applications in smart home appliances scheduling - Part I: Precedence graph simplification

In this and a companion paper a dynamic programming (DP) approach to solve a smart home appliances scheduling problem is considered. The challenge with solving the scheduling problem is the coupling of decision variables due to some time precedence constraints. In general, the system of precedence constraints may contain redundant constraints that offer opportunities for simplification. This simplification is desirable for reducing the computation effort of the nonserial DP procedure presented in the companion paper (i.e., Part II). The current paper establishes the uniqueness of the maximum set of redundant constraints and its polynomial-time solvability with optimality guarantee, under the sufficient and necessary condition that the precedence graph (a graph representation of the precedence constraints system) does not contain any cycle with nonnegative weight. A numerical case study indicates the efficiency of the proposed simplification algorithm versus the brute-force enumerative search. Besides helping to reduce the computation effort in the DP procedure described in the companion paper, the algorithm in the current paper solves a generalization of a precedence graph simplification problem arising from application areas such as parallel computing.
Energy Efficiency Evaluation of Multi-Tier Cellular Uplink Transmission Under Maximum Power Constraint

This paper evaluates the energy efficiency of uplink transmission in heterogeneous cellular networks (HetNets), where fractional power control (FPC) is applied at user equipments (UEs) subject to a maximum transmit power constraint. We first consider an arbitrary deterministic HetNet and characterize the properties of energy efficiency for UEs in different path loss regimes, or different access regions. By introducing the notion of transfer path loss, we reveal that, for UE whose path loss is below the transfer path loss, its energy efficiency highly depends on the value of power control coefficient adopted by FPC. In contrast, for UE with path loss above the transfer path loss, the uplink energy efficiency asymptotically decreases inversely with path loss, independent of the adopted power control coefficient. Based on these properties, we characterize the optimal power control coefficients for maximizing the energy efficiency of FPC in different access regions. Next, we extend the analysis to stochastic HetNets where UEs and BSs are distributed as independent Poisson point processes, and investigate the distribution of transmit power for uplink UEs. Moreover, the probability of truncation outage due to constrained maximal transmit power, as well as the average energy efficiency of UEs are analytically derived as functions of the BS and UE densities, power control coefficient, and receiver threshold. Simulation results validate the analytical results, show the consistency between deterministic and stochastic analyses, and suggest suitable power control coefficient for achieving energy efficient uplink transmission by FPC in HetNets.
Gas Sensing Based on a Nonlinear Response:  Discrimination between Hydrocarbons and Quantification of Individual Components in a Gas Mixture.

A novel sensing system is proposed based on the multidimensional information contained in a dynamic nonlinear response. A sinusoidal temperature change was applied to a SnO(2) semiconductor gas sensor, and the resulting output conductance of the sensor was analyzed by fast Fourier transformation (FFT). The higher harmonics of the FFT characterized the nonlinear properties of the response. The amplitudes of the higher harmonics of the FFT exhibit characteristic changes which depend on the chemical structure, concentration, and the kinetics of adsorption and the reaction of hydrocarbon gases and aromatic vapors on the sensor surface. In addition, it is possible to distinguish between gases in a gaseous mixture with a single detector using this dynamic nonlinear response. Nonlinear responses are discussed in relation to the kinetics of the reaction at the sensor surface and the temperature-dependent barrier potential of the semiconductor.
Women in executive power : a global overview

1. Introduction Gretchen Bauer and Manon Tremblay 2. Arab States Vania Carvalho Pinto 3. South and Southeast Asia Andrea Fleschenberg 4. Oceania Jennifer Curtin and Marian Sawer 5. Central and Eastern Europe Maxime Forest 6. Sub-Saharan Africa Gretchen Bauer 7. Latin America Tiffany D. Barnes and Mark P. Jones 8. North America Farida Jalalzai and Manon Tremblay 9. Western Europe Fiona Buckley and Yvonne Galligan 10. Nordic Countries Christina Bergqvist 11. Conclusion Manon Tremblay and Gretchen Bauer
Long-Term Treatment with the Apolipoprotein A1 Mimetic Peptide Increases Antioxidants and Vascular Repair in Type I Diabetic Rats

Apolipoprotein A1 mimetic peptide (D-4F), synthesized from D-amino acid, enhances the ability of high-density lipoprotein to protect low-density lipoprotein (LDL) against oxidation in atherosclerotic disease. Using a rat model of type I diabetes, we investigated whether chronic use of D-4F would lead to up-regulation of heme oxygenase (HO)-1, endothelial cell marker (CD31+), and thrombomodulin (TM) expression and increase the number of endothelial progenitor cells (EPCs). Sprague-Dawley rats were rendered diabetic with streptozotocin (STZ) and either D-4F or vehicle was administered, by i.p. injection, daily for 6 weeks (100 μg/100 g b.wt.). HO activity was measured in liver, kidney, heart, and aorta. After 6 weeks of D-4F treatment, HO activity significantly increased in the heart and aorta by 29 and 31% (p < 0.05 and p < 0.49), respectively. Long-term D-4F treatment also caused a significant increase in TM and CD31+ expression. D-4F administration increased antioxidant capacity, as reflected by the decrease in oxidized protein and oxidized LDL, and enhanced EPC function and/or repair, as evidenced by the increase in EPC endothelial nitric-oxide synthase (eNOS) and prevention of vascular TM and CD31+ loss. In conclusion, HO-1 and eNOS are relevant targets for D-4F and may contribute to the D-4F-mediated increase in TM and CD31+, the antioxidant and anti-inflammatory properties, and confers robust vascular protection in this animal model of type 1 diabetes.
Inflammatory Mechanisms Contributing to Pancreatic Cancer Development

Objective:Pancreatic cancer is the most deadly of all gastrointestinal (GI) malignancies, yet relatively little is known regarding mechanisms of tumor development including the role of inflammation. Summary Background Data:Chronic pancreatitis (CP) increases the risk of developing cancer by 10- to 20-fold; mediators of the chronic inflammatory process and the surrounding fibrotic stroma likely support a transformation to malignancy, yet the exact mechanisms remain undefined. The purpose of our present study was to determine potential inflammatory components in epithelial and stromal cells that may contribute to both CP and pancreatic cancers. Methods:Specimens of normal pancreas, CP, and pancreatic cancer were examined using laser-capture microdissection (LCM), gene array, and immunohistochemistry. Results:Gene array analysis from LCM-dissected tissues demonstrated: (i) increased expression of interleukin-8 (IL-8), an activator of the inflammatory factor nuclear factor-κB (NF-κB), and (ii) decreased expression of IκB (an inhibitor of NF-κB) in CP ductal cells compared with normal ducts. Compared with CP, cancers demonstrated: (i) increased expression of tumor related genes including S100A4, cyclin E1, and epidermal growth factor (EGF) receptor, and (ii) expression of matrix metalloproteinase 2, a pro-invasive factor for tumor cells, which was not present in the CP stroma. Increased staining of both the p50 NF-κB subunit and IKK&agr; kinase (a protein that allows activation of NF-κB) was noted in CP and cancers. Conclusions:Our results demonstrate that similar inflammatory components and downstream effectors are present in CP and pancreatic cancers. Importantly, these findings suggest that a common pathway for pancreatic cancer development may be through a chronic inflammatory process including stroma formation. These findings may lead to novel strategies for pancreatic cancer prophylaxis based on inhibition of inflammatory mediators.
Relation of Charging History to Field Ion Emission From Gold and Carbon Dust

A study of dust-grain charging plays a very important role in the understanding of complex (dusty) plasma. The dust grains are charged by several different processes (e.g., electron and ion attachments, secondary electron emission, photoemission, and field electron and ion emissions), and their charge significantly influences the surrounding plasma. Our laboratory experiment based on an electrodynamic quadrupole trap allows us to investigate some of these processes on a single isolated dust grain which can be trapped and influenced with different agents for a very long time (days). In this paper, we focused on the determination of the relation between charging conditions and the field-emission mechanism because this emission limits positive charges that dust grains can acquire due to photoemission, secondary emission, or ion attachment. The field-ion-emission process is based on the field ionization of the atoms that crosses a critical distance from the grain surface. We have found that the sources of these atoms are either the surrounding gas or the ions implanted into the grain and leaving it due to diffusion. The diffusion can be described by two time constants differing by an order of magnitude. We used two sets of dust grains: gold and amorphous carbon. The experimental results are confirmed by a simple model.
Privacy aware web services in the cloud

Data privacy and security continues to hinder wider adoption of cloud based web services for small to medium businesses. Existing privacy aware systems for cloud environments either assume that web service providers are trustworthy and can adequately enforce a client's privacy policies or adapt computationally expensive encryption techniques to minimize data security risks. In this paper, we propose, PASiC, a framework for Privacy Aware RESTful Web Services in the Cloud. PASiC provides lightweight data privacy features by allowing clients to define their specific privacy policies, obfuscation/encryption methods and collaboratively engage with the service providers to enforce these policies. Our framework is designed to facilitate integration with legacy systems. Our experimental evaluation shows that PASiC safeguards sensitive data throughout the data staging process, and show how it operates over different methods of encryption and obfuscation in terms of their performance.
Rapidly alternating COPP/ABV/IMEP is not superior to conventional alternating COPP/ABVD in combination with extended-field radiotherapy in intermediate-stage Hodgkin's lymphoma: final results of the German Hodgkin's Lymphoma Study Group Trial HD5.

PURPOSE To investigate whether treatment results in intermediate-stage Hodgkin's lymphoma can be improved by rapid application of non-cross-resistant drugs, the 10-drug regimen cyclophosphamide, vincristine, procarbazine, and prednisone (COPP), doxorubicin, bleomycin, and vinblastine (ABV), and ifosfamide, methotrexate, etoposide, and prednisone (IMEP), repeated every 6 weeks, was compared with conventional alternating COPP/doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) administered every 8 weeks. PATIENTS AND METHODS From January 1988 to January 1993, 996 patients in stage I or II Hodgkin's lymphoma with at least one risk factor (massive mediastinal tumor, massive spleen involvement, extranodal disease, elevated ESR, or more than two lymph node areas involved) and all patients in stage IIIA Hodgkin's lymphoma were randomized to receive two cycles of COPP/ABVD or COPP/ABV/IMEP followed by extended-field radiotherapy. RESULTS Both regimens produced similar rates for treatment responses (complete remission, 93% v 94%), freedom from treatment failure (80% v 79%), and overall survival (88% for both regimens) at a median follow-up time of 7 years. Most serious toxicities during chemotherapy were similar in both regimens. However, World Health Organization grade 3 and 4 leukocytopenia occurred significantly more frequently in the COPP/ABV/IMEP arm (53% v 44% of patients; P =.010). There were no differences in the number of serious infections and toxic deaths during therapy. The number of second malignancies was also the same in both arms (22 each). CONCLUSION Alternating COPP/ABVD and rapid alternating COPP/ABV/IMEP in combination with extended-field radiotherapy are equally effective in intermediate-stage Hodgkin's lymphoma and produce excellent long-term treatment results.
Characterization of hybrid toxins produced in Escherichia coli by assembly of A and B polypeptides from type I and type II heat-labile enterotoxins

The genes encoding the individual A and B polypeptides of the type I enterotoxin LTp-I and type II enterotoxins LT-IIa and LT-IIb were cloned and tested for complementation in Escherichia coli. Each gene encoding an A polypeptide was cloned into pACYC184, and each gene encoding a B polypeptide was cloned into the compatible plasmid Bluescript KS+. In addition, operon fusions representing all combinations of A and B genes were constructed in Bluescript KS+. Extracts from strains of E. coli expressing each combination of A and B genes, either from compatible plasmids or from operon fusions, were tested for immunoreactive holotoxin by radioimmunoassays and for toxicity by Y1 adrenal cell assays. Biologically active holotoxin was detected in each case, but the toxicity of extracts containing the hybrid toxins was usually less than that of extracts containing the wild-type holotoxins. The ganglioside-binding activity of each holotoxin was tested, and in each case, the B polypeptide determined the ganglioside-binding specificity. The A and B polypeptides of the type II heat-labile enterotoxins were also shown to form holotoxin in vitro without exposure to denaturing conditions, in contrast to the polypeptides of the type I enterotoxins that failed to form holotoxin in vitro under comparable conditions. These findings suggest that type I and type II enterotoxins have conserved structural features that permit their A and B polypeptides to form hybrid holotoxins, although the B polypeptides of the type I and type II enterotoxins have very little amino acid sequence homology.
In Vivo Mutations of Thymidylate Synthase (Encoded by thyA) Are Responsible for Thymidine Dependency in Clinical Small-Colony Variants of Staphylococcus aureus

ABSTRACT Trimethoprim-sulfamethoxazole (SXT)-resistant Staphylococcus aureus thymidine-dependent small-colony variants (TD-SCVs) are frequently isolated from the airways of cystic fibrosis (CF) patients, often in combination with isogenic normal strains if patients were treated with SXT for extended periods. As SXT inhibits the synthesis of tetrahydrofolic acid, which acts as a cofactor for thymidylate synthase (thyA), the survival of TD-SCVs depends exclusively on the availability of external thymidine. Since the underlying mechanism for thymidine dependency is unknown, we investigated if alterations in the thyA nucleotide sequences were responsible for this phenomenon. Sequence analysis of several clinical TD-SCVs and their isogenic normal strains with reference to previously published S. aureus thyA nucleotide sequences was performed. Three clinical TD-SCVs were complemented by transforming TD-SCVs with the vector pCX19 expressing ThyA from S. aureus 8325-4. Transcriptional analysis of metabolic and virulence genes and regulators (agr, hla, spa, citB, thyA, and nupC) was performed by quantitative reverse transcription-PCR. The previously published sequences of thyA and two normal clinical strains were highly conserved, while thyA of four normal strains and four SCVs had nonsynonymous point mutations. In 8/10 SCVs, deletions occurred, resulting in stop codons which were located in 4/10 SCVs close to or within the active site of the protein (dUMP binding). Complementation of TD-SCVs with thyA almost fully reversed the phenotype, growth characteristics, and transcription patterns. In conclusion, we demonstrated that mutations of the thyA gene were responsible for the phenotype of TD-SCVs. Complementation of TD-SCVs with thyA revealed that a functional ThyA protein is necessary and sufficient to change the SCV phenotype and behavior back to normal.
Skin tears and risk factors assessment: a systematic review on evidence‐based medicine

Skin tears represent a common condition of traumatic wounds, which may be encountered in some categories of individuals at the extremes of age, such as infants and the elderly. Despite the high prevalence and cost of these lesions, there has been little investigation into the risk factors that lead to this condition. The aim of this review was to systematically evaluate the main risk factors involved in development of skin tears. We planned to include all the studies dealing with risk factors related to skin tears. Only publications in English were considered. We excluded all the studies that did not properly fit our research question and those with insufficient data. Of the 166 records found, 24 matched our inclusion criteria. After reading the full‐text articles, we decided to exclude seven articles because of the following reasons: (1) not responding properly to our research questions and (2) insufficient data; the final set included 17 articles. From a literature search, we found the following main issues related to risk factors, which have been described in detail in this section: age‐related skin changes, dehydration, malnutrition, sensory changes, mobility impairment, pharmacological therapies and mechanical factors related to skin care practices. Our findings clearly show that in frail populations (especially infant and elderly), the stratification risk, as a primary prevention strategy, is an effective tool in avoiding the development of chronic wounds. The development and the implementation of prevention strategies based on appropriate knowledge of the risk factors involved and the adoption of correct techniques during skin care practices could reduce or even avoid the onset of skin tears.
Depressive neurosis

ABSTRACT– The results of a 7‐year follow‐up study of 50 former psychiatric inpatients with a diagnosis of depressive neurosis (ICD 300.4) who met the RDC criteria for Major Depression are reported. The follow‐up assessment of the patients included the use of standardized social, psychological and psychopathological instruments. In addition, the course of illness as well as the utilization of medical services and periods of working disability was evaluated. The results indicate a rather unfavourable course and outcome in terms of symptoms for approximately 40% of the sample, including six patients who had committed suicide after index discharge. Almost 40% of the sample showed mild chronic symptoms with persistent impairments in social functioning especially in the area of social interaction, whereas only 20% of the sample were classified as satisfactorily improved or completely remitted.
Attitude and Knowledge Changes in Collegiate Dancers following a Short-Term, Team-Centered Prevention Program on Eating Disorders

Eating knowledge, nutritional knowledge, and psychological changes among female collegiate dancers were examined before and after a 4-wk. team-centered program on sport nutrition, exercise, and disordered eating consequences. Collegiate female dancers from two NCAA Division I institutions participated in a control (n = 19; M age = 19.1 yr., SD = 1.0) or intervention (n = 21; M age = 19.2 yr., SD = 1.2) group. Measures were administered to both groups before and after intervention to assess eating disorders, depression, and nutritional and disordered eating knowledge. There was a statistically significant increase in scores on nutritional and overall eating disorder knowledge in the intervention group compared to the control group. Mean scores on depression, drive for thinness, body dissatisfaction, and maturity fears decreased in the intervention group.
The DNA-Damage Response to γ-Radiation Is Affected by miR-27a in A549 Cells

Perturbations during the cell DNA-Damage Response (DDR) can originate from alteration in the functionality of the microRNA-mediated gene regulation, being microRNAs (miRNAs), small non-coding RNAs that act as post-transcriptional regulators of gene expression. The oncogenic miR-27a is over-expressed in several tumors and, in the present study, we investigated its interaction with ATM, the gene coding for the main kinase of DDR pathway. Experimental validation to confirm miR-27a as a direct regulator of ATM was performed by site-direct mutagenesis of the luciferase reporter vector containing the 3′UTR of ATM gene, and by miRNA oligonucleotide mimics. We then explored the functional miR-27a/ATM interaction under biological conditions, i.e., during the response of A549 cells to ionizing radiation (IR) exposure. To evaluate if miR-27a over-expression affects IR-induced DDR activation in A549 cells we determined cell survival, cell cycle progression and DNA double-strand break (DSB) repair. Our results show that up-regulation of miR-27a promotes cell proliferation of non-irradiated and irradiated cells. Moreover, increased expression of endogenous mature miR-27a in A549 cells affects DBS rejoining kinetics early after irradiation.
AliMe Assist: An Intelligent Assistant for Creating an Innovative E-commerce Experience

We present AliMe Assist, an intelligent assistant designed for creating an innovative online shopping experience in E-commerce. Based on question answering (QA), AliMe Assist offers assistance service, customer service, and chatting service. It is able to take voice and text input, incorporate context to QA, and support multi-round interaction. Currently, it serves millions of customer questions per day and is able to address 85% of them. In this paper, we demonstrate the system, present the underlying techniques, and share our experience in dealing with real-world QA in the E-commerce field.