Miracle-dz/UniFAR-FTUs huggingface dataset:
A Dynamic Clustering Algorithm Design for C-RAN Based on Multi-Objective Optimization Theory

Cloud radio access network (C-RAN) is a new concept of network architecture, which brings a technical revolution into the wireless communication market and leads to some kind of all new mode of the future wireless communications. In this paper the clustering algorithm based on multi-objective optimization is investigated. The proposed algorithm aims at maximizing the throughput contribution of the Remote RF Head (RRH) to the whole system and minimizing its total power consumption with guaranteed energy efficiency of RRH. Using the novel greedy dynamic clustering algorithm, the joint capacity of RRHs is improved. The throughput of each RRH is first given using the pricing mechanism and the Pascoletti and Serafini Scalarization method is then implemented to solve the multiobjective optimization problem. Finally, the performance of the algorithm is assessed by the simulation results. It is shown that the novel dynamic clustering algorithm based on multiobjective optimization in the C-RAN architecture outperforms the traditional greedy clustering approach.
Parameters optimization of supercritical fluid-CO2 extracts of frankincense using response surface methodology and its pharmacodynamics effects.

The volatile oil parts of frankincense (Boswellia carterii Birdw.) were extracted with supercritical carbon dioxide under constant pressure (15, 20, or 25 MPa) and fixed temperature (40, 50, or 60°C), given time (60, 90, or 120 min) aiming at the acquisition of enriched fractions containing octyl acetate, compounds of pharmaceutical interest. A mathematical model was created by Box-Behnken design, a popular template for response surface methodology, for the extraction process. The response value was characterized by synthetical score, which comprised yields accounting for 20% and content of octyl acetate for 80%. The content of octyl acetate was determined by GC. The supercritical fluid extraction showed higher selectivity than conventional steam distillation. Supercritical fluid-CO(2) for extracting frankincense under optimum condition was of great validity, which was also successfully verified by the pharmacological experiments.
Lip pattern in the interpretation of human emotions

In this paper, lip features are applied to classify the human emotion using a set of irregular ellipse fitting equations using Genetic Algorithm (GA). South-east Asian and Japanese faces are considered in this study. The parameters relating the face emotions, in either case, are entirely different. All six universally accepted emotions are considered for classifications. The method that is fastest in extracting lip features is adopted in this study. Observation of various emotions of the subject leads to unique characteristic of lips. GA is adopted to optimise irregular ellipse characteristics of the lip features in each emotion. That is, the top portion of lip configuration is a part of one ellipse and the bottom of different ellipse. Two ellipse-based fitness equations are proposed for the lip configuration and relevant parameters that define the emotion are listed. This approach has given reasonably successful emotion classifications.
"GREEN BUSINESS PROCESS MANAGEMENT" IN MANUFACTURING FIRMS: EXAMINING THE ROLE OF UPSTREAM AND DOWNSTREAM SUPPLIERS

This research is undertaken with the aim of examining the influence of green supplier selection, green supplier monitoring and green supplier collaboration towards green business process management (GBPM) amongst Malaysian manufacturing corporations. Using the resource based view theoretical lens, a survey was conducted on 122 manufacturing corporations in Malaysia. The empirical analysis using the Partial Least Square (PLS) modeling technique revealed that green supplier monitoring and green supplier selection have a significant influence towards effective GBPM in the sample of manufacturing corporations. The influence of green supplier collaboration on the other hand is not significant.
Population Pharmacokinetic/Pharmacodynamic Modeling of Tumor Size Dynamics in Pembrolizumab‐Treated Advanced Melanoma

Pembrolizumab is a potent immune‐modulating antibody active in advanced melanoma, as demonstrated in the KEYNOTE‐001, ‐002, and ‐006 studies. Longitudinal tumor size modeling was pursued to quantify exposure‐response relationships for efficacy. A mixture model was first developed based on an initial dataset from KEYNOTE‐001 to describe four patterns of tumor growth and shrinkage. For subsequent analyses, tumor size measurements were adequately described by a single consolidated model structure that captured continuous tumor size with a combination of growth and regression terms, as well as a fraction of tumor responsive to therapy. This revised model structure provided a framework to efficiently evaluate the impact of covariates and pembrolizumab exposure. Both models indicated that exposure to the drug was not a significant predictor of tumor size response, demonstrating that the dose range evaluated (2 and 10 mg/kg every 3 weeks) is likely near or at the plateau of maximal response.
Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum

The ventral pallidum (VP) is a major intermediary in the prefrontal cortical circuitry regulating sensorimotor gating and locomotor behavior, both of which are potently modulated by catecholamines. The VP catecholaminergic innervation is derived from midbrain dopaminergic neurons that differ in expression levels of the dopamine transporter (DAT) and from brainstem noradrenergic neurons without DAT. The preferentially low level of DAT in dopaminergic terminals in the prefrontal cortex and in striatal regions projecting more extensively to the VP medial (VPm) compared with VP lateral (VPl) compartment suggests possible region‐specific differences in VP axonal distribution of DAT. To test this hypothesis, we examined the electron microscopic localization of DAT and the catecholamine‐synthesizing enzyme, tyrosine hydroxylase (TH), in the VPm and VPl of rat brain. In both regions, DAT and TH were localized primarily in small unmyelinated axons and morphologically heterogeneous axon terminals. DAT‐immunogold particles were few in number, but mostly located on the plasma membrane. In contrast, TH immunoreactivity was distributed in the cytoplasm of individual profiles, many of which were without detectable DAT. In comparison with TH, the mean area density of DAT‐labeled axons was low throughout the VP. The mean area density of DAT‐immunogold axon terminals, however, was significantly higher in VPl than in VPm, whereas that of TH‐labeled axons was higher in VPm than in VPl. This dissociation suggests that, compared to the VPl, the VPm receives the greatest input from catecholaminergic afferents that are either nondopaminergic or characterized by having low levels or less terminal distributions of DAT. J. Comp. Neurol. 468:395–409, 2004. © 2003 Wiley‐Liss, Inc.
Effect Of Intermittent And Continuous Training On Body Composition Cardiorespiratory Fitness And Lipid Profile In Obese Adolescents

We assessed the cardiorespiratory responses and exercise tolerance during 12 week training (intermittent vs. continuous) in obese children. Twenty nine obese adolescent were randomly allocated into either the IT or CT group. The CT group performed a 30 to 40 minute continuous exercises a 60% to 70 % of vVO2max. IT group was instructed to run for 2 min interspersed with recovery periods of one minute. The exercise intensity was 80% of the vVO2max increased by 5% every four weeks. Along the training period, the increase of the load was carried out by increasing the intensity and the number of repetitions. At baseline and after 12 weeks of intervention, cardiorespiratory fitness, body composition and lipid parameters were assessed. Improvement of Weight and Fat mass were significantly lower during the intermittent exercise (Weight (kg) =81.1±13.8 vs. 79.1±13.3 and Fat mass = 33.8 ±6.7 vs. 31.8 ±7.1 respectively) compared to the continuous exercise in the obese adolescent (Weight = 80.7 ±13.2 vs. 75.8 ±11.2 and fat mass = 33.7 ± 6.7 vs. 28.8±5.1 respectively). After the continuous training program, significant beneficial effects on the HDL-C (mmol.l-1) (0.97 ±0.06 vs. 1.12 ±0.1), ratio LDL-C/HDL-C (2.93±0.22 vs. 2.39±0.13), ratio TC/HDL-C (4.57±0.19 vs. 3.92±0.20). Improved capacity cardiorespiratory best of IT versus CT, at the Resting. HR (beats. m) (83± 4 vs78±3 and 78 ±4 vs. 76 ±3 respectively), systolic BP (mmHg) (p<0.01 vs. NS), VO2max (ml.min .k) (p<0.001 vs. p<0.05) and recovery index (p<0. 01 vs. p<0.05). Greater improvement in cardiorespiratory fitness of intermittent group compared to the continuous group. The other subjects who completed the continuous training program have improved their lipid profiles and their body composition more that the group intermittent.
Physical Sensors for Liquid Properties

In this contribution, an overview is given of physical sensors for the determination and monitoring of the state of liquids. Basic liquid properties in different energy domains (electrical, mechanical, thermal, and optical) are discussed and their application in sensors is reviewed. Such sensors are useful for bulk fluids, but also for very small liquid volumes such as used in microfluidic devices. In addition, the capability of physical chemosensors for the retrieval of chemical or biochemical information of the liquid is explicated.
Further insights into the no-reflow phenomenon after primary angioplasty in acute myocardial infarction: the role of microthromboemboli.

We tested the hypothesis that when acute coronary occlusion is caused by thrombus, part of the no-reflow phenomenon may result from spontaneous or coronary angioplasty-induced microthromboemboli, and that this phenomenon may be partly or wholly reversible. Accordingly, a thrombus was created in the left anterior descending coronary artery of 6 dogs and was labeled in vivo with (99m)Tc-DMP-444 that binds to the IIb/IIIa platelet receptor. Angioplasty was then performed to obtain thrombolysis in myocardial infarction grade-3 flow. Myocardial contrast echocardiography was performed 15 and 60 minutes after recanalization to define perfusion defect size. (99m)Tc-autoradiography and infarct size (IS) measurement were performed postmortem. An additional 5 dogs with coronary artery ligation followed by reperfusion served as control animals. These dogs also underwent myocardial contrast echocardiography and in vivo labeling with (99m)Tc-DMP-44. (99m)Tc uptake was significantly higher in the reperfused bed in dogs with thrombus compared with control dogs (2.7 +/- 0.9 vs 1.4 +/- 0.3 counts/pixel(-1)/min(-1), P =. 01) indicating the presence of microthromboemboli. Perfusion defect size early (15 minutes) after recanalization was smaller than the hot spot on autoradiography and overestimated IS in dogs with thrombus. Perfusion defect size decreased with time and was closer to IS 60 minutes after recanalization. The dogs with thrombi demonstrated larger IS/risk area ratios compared with the 5 control dogs (46 +/- 6% vs 27 +/- 12%, P =.04). We conclude that part of the no-reflow phenomenon seen after angioplasty in acute coronary thrombosis is a result of microthromboemboli and is mostly reversible. No reflow late after reperfusion is a result of tissue necrosis. The thrombus burden also affects ultimate IS.
Structural and mechanistic analysis of engineered trichodiene synthase enzymes from Trichoderma harzianum: towards higher catalytic activities empowering sustainable agriculture

Trichoderma spp. are well-known bioagents for the plant growth promotion and pathogen suppression. The beneficial activities of the fungus Trichoderma spp. are attributed to their ability to produce and secrete certain secondary metabolites such as trichodermin that belongs to trichothecene family of molecules. The initial steps of trichodermin biosynthetic pathway in Trichoderma are similar to the trichothecenes from Fusarium sporotrichioides. Trichodiene synthase (TS) encoded by tri5 gene in Trichoderma catalyses the conversion of farnesyl pyrophosphate to trichodiene as reported earlier. In this study, we have carried out a comprehensive comparative sequence and structural analysis of the TS, which revealed the conserved residues involved in catalytic activity of the protein. In silico, modelled tertiary structure of TS protein showed stable structural behaviour during simulations. Two single-substitution mutants, i.e. D109E, D248Y and one double-substitution mutant (D109E and D248Y) of TS with potentially higher activities are screened out. The mutant proteins showed more stability than the wild type, an increased number of electrostatic interactions and better binding energies with the ligand, which further elucidates the amino acid residues involved in the reaction mechanism. These results will lead to devise strategies for higher TS activity to ultimately enhance the trichodermin production by Trichoderma spp. for its better exploitation in the sustainable agricultural practices.
Tweet polarity classification focused on positive and negative term frequency ratio

With the wide spread of SNS (including Twitter, Facebook, and Flickr), there is a great demand for analyzing the associated Web contents consisting of a vast amount of opinions posted from anonymous users. Such opinions usually have explicit or implicit polarities. The polarity determination for short texts like Twitter is, however, very difficult. In this paper, we propose a method for sentiment analysis in Twitter, focusing on the proportion of term frequencies between positive and negative polarities. We compare our proposed method against several other methods. From the experiments using SemEval2016 Twitter data, we demonstrate that our proposed method outperforms the same team in terms of F1-score.
Adenosine triphosphate conservation in metabolic regulation. Rat liver citrate cleavage enzyme.

Abstract The citrate cleavage enzyme (EC 4.1.3.8) of rat liver is inhibited by adenosine diphosphate, which appears to compete with adenosine triphosphate. This effect may ensure that fatty acids are produced only when the ATP level is high. The "energy charge" of the adenylate system, defined as (ATP + ½ ADP)/(AMP + ADP + ATP), is proposed as a fundamental metabolic control parameter. Enzymes that utilize ATP and are inhibited by ADP or AMP will yield steep curves of velocity as a function of energy charge (resembling the steep curves of velocity as a function of substrate concentration that are characteristic of many regulatory enzymes) even in the absence of multiple sites and cooperative binding.
Two E2 binding sites alone are sufficient to function as the minimal origin of replication of human papillomavirus type 18 DNA

Replication of papillomaviruses requires an origin of replication and two virus-encoded proteins, E1 and E2. Using a transient replication assay for human papillomavirus type 18 (HPV-18) DNA, we have found that two adjacent sequences present within the origin of replication can independently support replication. The first, a 77-bp region, contains one E2 binding site (E2BS) and a 16-bp inverted repeat element that probably corresponds to the E1 binding site (E1BS). The other, an 81-bp region, includes two E2BS but lacks the putative E1BS. A synthetic 33-bp oligonucleotide containing two high-affinity E2BS was also found to function as an origin of replication. Replication of all these plasmids was absolutely dependent on the presence of the HPV-18 E1 and E2 proteins. The HPV-1a E1 and E2 proteins were also found to support replication of a plasmid containing the complete HPV-18 origin but failed to replicate a plasmid containing two E2BS alone. Our results suggest that the E2 protein can target E1 to the origin through the formation of an E1-E2 complex which is likely to be involved the initiation of replication.
Trade-Based Money Laundering: The Next Frontier in International Money Laundering Enforcement

Uncover the financial fraud that funds terrorist organizations Trade-Based Money Laundering is an authoritative examination of this burgeoning phenomenon, now coming under scrutiny in the War on Terror. This book walks you through the signs and patterns of trade-based money laundering (TBML) to help you recognize it when it occurs, and shows you how data and analytics can be used to detect it. You'll learn the common value transfer techniques including invoice fraud, over-and-under invoicing, and misrepresentation, and learn why analytic detection systems have yet to be implemented despite the existence of copious data. Case studies from around the world highlight the real-life implications of the concepts and processes presented in the text, giving you a first-hand view of the mechanisms at work inside this expanding illegal market.
Transformation Model from Attention and Intention to Sales on Experience Economic

Development of wireless communication and Internet is impelling the innovation of purchasing behavior. Through increasing network resources, consumers can optimize their purchase selection path by browsing the products' web pages and consulting shopping details or experience from existing users according to the collected relevant interesting information. Basing on SICAS purchase behavior model, this study uses Internet consumer public index as an example to analyze how consumers' feeling, interaction, communication turn to purchase behavior. Stepwise regression and differential cryptanalysis of the attention, intention and the transformation model of sale are used for empirical analysis. The conclusion shows that attention and intention promote the growth of sale. Furthermore, attention has significant positive effect on promotion of sale, whereas the intention effect is not obvious. However, setting attention as control variables can make the positive correlation of intention and sale obvious. Therefore, strengthening consumers' initiative attention, purchase intentions and communication will promote the purchase.
INTERNATIONALIZATION OF FINANCIAL SERVICES IN ASIA-PACIFIC AND THE WESTERN HEMISPHERE

† Patricio Contreras (pcontreras@oas.org) is senior trade specialist with the Trade Unit of the Organization of American States and Research Associate with the Center for Latin America Issues of George Washington University. Soonhwa Yi (syi@oas.org) is trade specialist with the Trade Unit of the Organization of American States. This paper was written at the request of the Pacific Economic Cooperation Council Finance Forum and a preliminary version was presented at its 2nd annual conference held in Hua Hin, Thailand on July 8-9, 2003. We are grateful to the participants of this conference for their very pertinent and thoughtful comments. ‡ The ideas, views and opinions expressed in this document are the exclusive responsibility of the authors and do not necessarily reflect the views of the OAS General Secretariat and the George Washington University.
Apigenin, a plant‐derived flavone, activates transient receptor potential vanilloid 4 cation channel

BACKGROUND AND PURPOSE Transient receptor potential vanilloid 4 (TRPV4) is a Ca2+‐permeable channel with multiple modes of activation. Apigenin is a plant‐derived flavone, which has potential preventive effects on the development of cardiovascular disease. We set out to explore the effects of apigenin on TRPV4 channel activity and its role in vasodilatation.
Eukaryotic Translation Initiation Factors 4G and 4A from Saccharomyces cerevisiae Interact Physically and Functionally

ABSTRACT The initiation of translation in eukaryotes requires several multisubunit complexes, including eukaryotic translation initiation factor 4F (eIF4F). In higher eukaryotes eIF4F is composed of the cap binding protein eIF4E, the adapter protein eIF4G, and the RNA-stimulated ATPase eIF4A. The association of eIF4A withSaccharomyces cerevisiae eIF4F has not yet been demonstrated, and therefore the degree to which eIF4A’s conserved function relies upon this association has remained unclear. Here we report an interaction between yeast eIF4G and eIF4A. Specifically, we found that the growth arrest phenotype associated with three temperature-sensitive alleles of yeast eIF4G2 was suppressed by excess eIF4A and that this suppression was allele specific. In addition, in vitro translation extracts derived from an eIF4G2 mutant strain could be heat inactivated, and this inactivation could be reversed upon the addition of recombinant eIF4A. Finally, in vitro binding between yeast eIF4G and eIF4A was demonstrated, as was diminished binding between mutant eIF4G2 proteins and eIF4A. In total, these data indicate that yeast eIF4G and eIF4A physically associate and that this association performs an essential function.
Random amplified polymorphic DNA assay is less discriminant than pulsed-field gel electrophoresis for typing strains of methicillin-resistant Staphylococcus aureus

Twenty-six strains of methicillin-resistant Staphylococcus aureus with different pulsed-field gel electrophoresis fingerprints were tested by random amplified polymorphic DNA assay with three primers, resulting in 15 to 20 different random amplified polymorphic DNA fingerprints. By summing the results for the three primers, the number of different fingerprints increased to 25, but two strains could not be differentiated. We conclude that pulsed-field gel electrophoresis remains the best method of typing methicillin-resistant S. aureus strains.
Impedance Shaping of the Grid-Connected Inverter with LCL Filter to Improve Its Adaptability to the Weak Grid Condition

The current-controlled grid-connected inverter with LCL filter is widely used in the distributed generation system (DGS), due to its fast dynamic response and better power quality features. However, with the increase of power injected into the grid, control performances of the inverter will be significantly influenced by the nonideal grid conditions. Specifically, the possible wide variation of the grid impedance challenges the system stability. Meanwhile, background harmonics of the grid can greatly distort the injected current. Therefore, the control of the inverter should be designed with strong stability-robustness and high harmonic-rejection-ability, both of which correlate closely with the inverter output impedance. However, it is difficult to shape the output impedance into the one with a desirable characteristic simply by adjusting the current loop gain. In this paper, an impedance shaping method is proposed with virtual impedances, and the current control loop can be designed independently. The implementation and parameter design of the virtual impedances are studied under the practical considerations. With this proposed method, the grid-connected inverter can work stably over a wide range of the typical inductive-resistive grid impedance and exhibit strong rejection ability of grid-voltage harmonics. Experimental results from a 6-kW single-phase grid-connected inverter confirm the effectiveness of the proposed method.