Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk-avoiding cultures toward achievement of knowledge sharing

Purpose – The knowledge base of a firm is increasingly believed to underlie firm performance, and culture is commonly viewed as the major obstacle to effective knowledge management. This study seeks to evaluate the relevance of organizational culture and to explore how it can influence the achievement of knowledge sharing within an enterprise.Design/methodology/approach – An empirical survey of Taiwan's firms was conducted to study organizational cultures, but also to determine how risk‐avoiding culture affects the achievement of knowledge sharing.Findings – An effective culture is formed by process formalization and tendentiousness of a defensively firm attitude to decision making should be developed. Furthermore, management should plan a healthy empowerment system to encourage employees to fully utilize their talents and skills in their jobs.Research limitations/implications – This study raises questions regarding the most appropriate combination of risk‐avoiding cultures for knowledge sharing. Since it.
Information Feedback for Skill Acquisition: Instantaneous Knowledge of Results Degrades Learning

The role of acquired error-detection capabilities in skill learning was investigated by manipulating the delay of knowledge of results (KR). Compared with delayed feedback, instantaneous KR should be detrimental to the learning of error-detection capabilities because it should tend to block spontaneous subjective evaluation of response-produced feedback. Weaker error-detection capabilities should then be evident on delayed no-KR retention tests. During acquisition, one group of subjects received KR after a delay of a few seconds while another group received KR instantaneously; then both were evaluated on several retention tests. Using a timing task with two reversals in direction (Experiment 1) and a coincident-timing task (Experiment 2), we found that, relative to delayed feedback, instantaneous KR degraded learning as measured on delayed retention tests. Although the KR-delay interval has traditionally been considered of minor importance for skill learning, the present findings suggest that very short KR-delays interfere with learning, perhaps by degrading the acquisition of error-detection capabilities. During the 1970s, numerous researchers suggested that skill learning not only results in more effective movement performance but also is manifested in terms of heightened sensitivity of the learner to detect and correct errors. Since then, several attempts have been undertaken to measure the strength of error-detection capabilities by means of subjective-error estimations (e.g., Newell, 1974; Newell & Boucher, 1974; Newell & Chew, 1974; Schmidt & White, 1972; Schmidt & Wrisberg, 1973). Using this technique, Schmidt and White (1972) found that correlations between objective and estimated error increased with practice on a ballistic-timing task, which was interpreted as the acquisition of the capability to detect errors with task experience. Various theories of motor learning (Adams, 1971; Schmidt, 1975) accounted for these findings by assuming that response-produced feedback (from the moving limbs, audition, vision, etc.) can be related to information about the success of the movement in terms of the environ
INVITED PAPER Special Section on Advanced Log Processing and Office Information Systems Toward More Secure and Convenient User Authentication in Smart Device Era

With the rapid spread of smart devices, such as smartphones and tablet PCs, user authentication is becoming increasingly important because various kinds of data concerning user privacy are processed within them. At present, in the case of smart devices, password-based authentication is frequently used; however, biometric authentication has attracted more attention as a user authentication technology. A smart device is equipped with various sensors, such as cameras, microphones, and touch panels, many of which enable biometric information to be obtained. While the function of biometric authentication is available in many smart devices, there remain some problems to be addressed for more secure and convenient user authentication. In this paper, we summarize the current problems with user authentication on smart devices and propose a novel user authentication system based on the concept of context awareness to resolve these problems. We also present our evaluation of the performance of the system by using biometric information that was acquired from smart devices. The evaluation demonstrates the effectiveness of our system. key words: smart device, user authentication, biometrics, context awareness, environment recognition
Event-related functional MRI: implications for cognitive psychology.

Functional magnetic resonance imaging (fMRI) has rapidly emerged as a powerful technique in cognitive neuroscience. We describe and critique a new class of imaging experimental designs called event-related fMRI that exploit the temporal resolution of fMRI by modeling fMRI signal changes associated with behavioral trials as opposed to blocks of behavioral trials. Advantages of this method over block designs include the ability to (a) randomize trial presentations, (b) test for functional correlates of behavioral measures with greater power, (c) directly examine the neural correlates of temporally dissociable components of behavioral trials (e.g., the delay period of a working memory task), and (d) test for differences in the onset time of neural activity evoked by different trial types. Consequently, event-related fMRI has the potential to address a number of cognitive psychology questions with a degree of inferential and statistical power not previously available.
Geocoding of traffic-related events from Twitter

Nowadays social networks provide information with high correlation with events that are occurring in the worldwide. Twitter is a microblogging network of real time posts in which people know different classes of events such as concerts, festivals, demonstrations, etc. Other relevant topic is traffic congestions; user-generated content is useful to assist drivers in avoiding crowded areas. Therefore, this work is oriented towards following specific steps focused on improving the geocoding of traffic-related events that are associated with a number of geographic elements. Preliminary results have increased the precision and recall of locating geographic elements, achieving 85% and 83%, from a baseline of 36% and 30% respectively.
Value of Whole-Body Turbo Short Tau Inversion Recovery Magnetic Resonance Imaging With Panoramic Table For Detecting Bone Metastases: Comparison With 99MTc-Methylene Diphosphonate Scintigraphy

Objective: The objectives of this study were to assess the efficacy and reliability of whole-body turbo short tau inversion recovery (STIR) magnetic resonance imaging (MRI) for detecting skeletal metastasis and to compare the results with those of bone scintigraphy. Methods: Twenty-six patients with primary cancer (mean age = 56 years, age range: 34-75 years) were assessed for bone metastasis with whole-body MRI and bone scintigraphy. Eight bone regions in each patient were assessed (total of 208 sites) with each of these 2 techniques. A turbo STIR sequence and panoramic table were used during MRI. Whole-body MRI and scintigraphy findings were compared with biopsy or follow-up imaging results. Results: After at least 12 months of follow-up, 9 patients had bone metastases in a total of 31 sites. Whole-body MRI showed 29 metastases (94%) in the total 208 skeletal sites investigated in the 26 patients. Bone scintigraphy revealed metastases in 16 (52%) of the 208 sites. Conclusion: Whole-body turbo STIR MRI is a reliable method for screening patients with suspected skeletal metastases. This technique is also advantageous in that it reveals extraskeletal organ and soft tissue metastases.
Estimation of CO2 storage capacity in Qianjiang depression area in Jianghan basin, China

Storage of CO2 in deep formations such as saline aquifers, gas and oil reservoirs, and coal beds is a viable option for reducing the amount of CO2 released to the atmosphere. The goal of this paper is to evaluate the storage capacity in the target formation located in the central China. The CO2 storage capacity estimated through the quick assessment is compared with the “true” values obtained using detailed numerical simulations of CO2 and brine transport in a two-dimensional radial system. The estimated capacity values clearly demonstrated the different storage capacities in an open and closed system, with the former offering much higher storage potential. This study showed that when the seal permeability was below 10−19 m2 the system acts like a closed-system, as only a small fraction of brine escapes through the caprock and baserock)
Imaging of glutamate neurotransmitter alterations in Alzheimer's disease

Glutamate (Glu) is a major excitatory neurotransmitter in the brain and has been shown to decrease in the early stages of Alzheimer's disease (AD). Using a glutamate chemical (amine) exchange saturation transfer (GluCEST) method, we imaged the change in [Glu] in the APP‐PS1 transgenic mouse model of AD at high spatial resolution. Compared with wild‐type controls, AD mice exhibited a notable reduction in GluCEST contrast (~30%) in all areas of the brain. The change in [Glu] was further validated through 1H MRS. A positive correlation was observed between GluCEST contrast and 1H MRS‐measured Glu/total creatine ratio. This method potentially provides a novel noninvasive biomarker for the diagnosis of the disease in preclinical stages and enables the development of disease‐modifying therapies for AD. Copyright © 2012 John Wiley & Sons, Ltd.
Capturing the Asc1p/Receptor for Activated C Kinase 1 (RACK1) Microenvironment at the Head Region of the 40S Ribosome with Quantitative BioID in Yeast*

The Asc1 protein of Saccharomyces cerevisiae is a scaffold protein at the head region of ribosomal 40S that links mRNA translation to cellular signaling. In this study, proteins that colocalize with Asc1p were identified with proximity-dependent Biotin IDentification (BioID), an in vivo labeling technique described here for the first time for yeast. Biotinylated Asc1p-birA*-proximal proteins were identified and quantitatively verified against controls applying SILAC and mass spectrometry. The mRNA-binding proteins Sro9p and Gis2p appeared together with Scp160p, each providing ribosomes with nuclear transcripts. The cap-binding protein eIF4E (Cdc33p) and the eIF3/a-subunit (Rpg1p) were identified reflecting the encounter of proteins involved in the initiation of mRNA translation at the head region of ribosomal 40S. Unexpectedly, a protein involved in ribosome preservation (the clamping factor Stm1p), the deubiquitylation complex Ubp3p-Bre5p, the RNA polymerase II degradation factor 1 (Def1p), and transcription factors (Spt5p, Mbf1p) colocalize with Asc1p in exponentially growing cells. For Asc1R38D, K40Ep, a variant considered to be deficient in binding to ribosomes, BioID revealed its predominant ribosome localization. Glucose depletion replaced most of the Asc1p colocalizing proteins for additional ribosomal proteins, suggesting a ribosome aggregation process during early nutrient limitation, possibly concomitant with ribosomal subunit clamping. Overall, the characterization of the Asc1p microenvironment with BioID confirmed and substantiated our recent findings that the β-propeller broadly contributes to signal transduction influencing phosphorylation of colocalizing proteins (e.g. of Bre5p), and by that might affect nuclear gene transcription and the fate of ribosomes.
Social phobia in spasmodic torticollis

OBJECTIVES To study the prevalence of psychiatric comorbidity assessed by the use of a structured clinical interview in a large, representative sample of patients with spasmodic torticollis (ST) and to test the hypothesis that social phobia would be highly prevalent. METHODS In a consecutive cohort of 116 patients with ST treated with botulinum toxin overall psychiatric comorbidity was studied prospectively with the structured clinical interview (SCID) for DSM-IV axis I disorders. Physical disability and psychosocial variables were also assessed with standardised self rating questionnaires. RESULTS 41.3% of the subjects met DSM-IV clinical criteria A-G for current social phobia as the primary psychiatric diagnosis. This figure rose to 56% including secondary and tertiary psychiatric diagnosis. There was no correlation between severity of disease (Tsui score, severity of pain, body image dissatisfaction score) and psychiatric comorbidity. The only significant predictor of psychiatric comorbidity was depressive coping behaviour (logistic regression analysis, p<0.01; OR=10.8). Compared with a representative sample of the general adult population, in the patients with ST the prevalence of clinically relevant social phobia is 10-fold, of mood disorders 2.4-fold, and of lifetime psychiatric comorbidity 2.6-fold increased. CONCLUSIONS A particularly high prevalence of social phobia was found in the cohort of patients with ST. The finding of a high prevalence of social phobia and depressive coping behaviour as the main predictor of psychiatric comorbidity may make a subgroup of patients with ST particularly amenable to specific psychotherapeutic interventions.
Functional Annotation of Class I Lysyl-tRNA Synthetase Phylogeny Indicates a Limited Role for Gene Transfer

ABSTRACT Functional and comparative genomic studies have previously shown that the essential protein lysyl-tRNA synthetase (LysRS) exists in two unrelated forms. Most prokaryotes and all eukaryotes contain a class II LysRS, whereas most archaea and a few bacteria contain a less common class I LysRS. In bacteria the class I LysRS is only found in the α-proteobacteria and a scattering of other groups, including the spirochetes, while the class I protein is by far the most common form of LysRS in archaea. To investigate this unusual distribution we functionally annotated a representative phylogenetic sampling of LysRS proteins. Class I LysRS proteins from a variety of bacteria and archaea were characterized in vitro by their ability to recognize Escherichia coli tRNALys anticodon mutants. Class I LysRS proteins were found to fall into two distinct groups, those that preferentially recognize the third anticodon nucleotide of tRNALys (U36) and those that recognize both the second and third positions (U35 and U36). Strong recognition of U35 and U36 was confined to the pyrococcus-spirochete grouping within the archaeal branch of the class I LysRS phylogenetic tree, while U36 recognition was seen in other archaea and an example from the α-proteobacteria. Together with the corresponding phylogenetic relationships, these results suggest that despite its comparative rarity the distribution of class I LysRS conforms to the canonical archaeal-bacterial division. The only exception, suggested from both functional and phylogenetic data, appears to be the horizontal transfer of class I LysRS from a pyrococcal progenitor to a limited number of bacteria.
Multi-step approach for thermal optimization of 3D-IC and package

The move from 2D to 3D integration of digital electronic systems (e.g. a multiprocessor with memory) offers a great deal of advantages and is clearly the most promising option for designing future systems. However, the density of the heat dissipation spots is much higher in 3D systems. In the design of such systems, the temperature distribution of the whole system including the package solution must be consider and optimized. In this paper a common optimization approach for early (pathfinding) and later (floorplan) timing and thermal optimization is presented. The developed optimization engine can be used - with different inputs - for both steps (pathfinding and floorplanning). The developed flow is successfully applied to a 3D VLIW-processor.
Grading of subarachnoid hemorrhage: modification of the world World Federation of Neurosurgical Societies scale on the basis of data for a large series of patients.

OBJECTIVE The goals of this study were to use a large, prospectively collected, multicenter database for patients with aneurysmal subarachnoid hemorrhage (SAH) who were treated between 1991 and 1997 to determine the prognostic significance of clinical and radiological factors for outcomes and to use those factors to develop a grading scale to predict outcomes. METHODS A total of 3567 patients with SAH who were entered into four randomized clinical trials of tirilazad were studied. Outcomes were assessed 3 months after SAH, with the Glasgow Outcome Scale. Twenty clinical and radiological factors were entered into univariate and multivariate analyses, to determine factors prognostic for outcomes. Grading scales based on the most powerful prognostic parameters were statistically derived and validated and were compared with the World Federation of Neurosurgical Societies (WFNS) grading scale. RESULTS Factors predictive of outcomes included age, WFNS grade, history of hypertension, systolic blood pressure at admission, ruptured aneurysm location and size, blood clot thickness on computed tomographic scans, and angiographic vasospasm at admission. A grading scale using these factors could be derived; it predicted outcomes more accurately than did the WFNS scale, although it would be more complex to use. CONCLUSION Outcome prediction after SAH can be improved by adding additional clinical and radiological factors to the WFNS scale, albeit with added complexity.
Pigmented villonodular synovitis of the temporomandibular joint with intracranial extension: A case series and systematic review

Pigmented villonodular synovitis (PVNS) is a rare proliferative disorder of the synovial membrane. PVNS generally affects large joints but occasionally involves the temporomandibular joint (TMJ), with occasional extension into the middle cranial fossa. The purpose of this study was to report our experience with PVNS along with a focused literature review.
Chromosomal instability determines taxane response

Microtubule-stabilizing (MTS) agents, such as taxanes, are important chemotherapeutics with a poorly understood mechanism of action. We identified a set of genes repressed in multiple cell lines in response to MTS agents and observed that these genes are overexpressed in tumors exhibiting chromosomal instability (CIN). Silencing 22/50 of these genes, many of which are involved in DNA repair, caused cancer cell death, suggesting that these genes are involved in the survival of aneuploid cells. Overexpression of these “CIN-survival” genes is associated with poor outcome in estrogen receptor–positive breast cancer and occurs frequently in basal-like and Her2-positive cases. In diploid cells, but not in chromosomally unstable cells, paclitaxel causes repression of CIN-survival genes, followed by cell death. In the OV01 ovarian cancer clinical trial, a high level of CIN was associated with taxane resistance but carboplatin sensitivity, indicating that CIN may determine MTS response in vivo. Thus, pretherapeutic assessment of CIN may optimize treatment stratification and clinical trial design using these agents.
A 2.1 μW area-efficient capacitively-coupled chopper instrumentation amplifier for ECG applications in 65 nm CMOS

This paper describes a capacitively-coupled chopper instrumentation amplifier for use in electrocardiography (ECG). The amplifier's gain is accurately defined by a capacitive feedback network, while a DC servo loop rejects the DC offset generated by the electrode-tissue interface. The high-pass corner frequency established by the servo loop is realized by an area-efficient switched-capacitor integrator. Additional feedback loops are employed to boost the amplifier's input-impedance to 80 MΩ and to suppress the chopper ripple. Implemented in a 65 nm CMOS technology, the amplifier draws 2.1 μA from a 1 V supply and occupies 0.2 mm2.
Isoforms of the alpha subunit of Na,K-ATPase and their significance.

Recent studies of the Na,K-ATPase have demonstrated that multiple isoforms of both the alpha and beta subunits exist and that these are expressed in a tissue and developmental specific manner. In the case of the alpha subunit, there are three known isoforms, alpha 1, alpha 2 and alpha 3. We have examined adult human heart for the presence of these isoforms and found that all three exist in approximately equal amounts. This is in contrast to the adult rat heart which contains only alpha 1 and alpha 2 isoforms. The difference in abundance of various isoforms in various tissues could result from the necessity to express Na,K-ATPase with different properties at various developmental stages or in specific cell types. For example, enzymes with differences in Na+ or K+ affinity or the ability to respond to various effector molecules may be required. Alternatively, the presence of three isoforms may simply result from the triplication of the alpha subunit gene and the divergence of expression of these genes during evolution. In this case the isozymes would not confer a specific function to the Na,K-ATPase. In order to provide information with respect to these two alternatives, cell lines producing rat alpha 1, alpha 2 and alpha 3 were developed and the enzymatic properties of the resulting enzyme determined. The results indicate that Na,K-ATPase carrying the alpha 1 are alpha 2 isoforms are fairly similar while enzyme with the alpha 3 isoform differs in its apparent affinity for sodium. The K0.5 for Na+ is approximately three fold lower for this isoform. (ABSTRACT TRUNCATED AT 250 WORDS)
Gaining Insight from Flexible Models

Summary Objectives: We present results from a secondary prevention trial of coronary heart disease (CHD) in the Czech male population from northern Bohemia with the history of myocardial infarction (MI) and high prevalence of metabolic syndrome. We compare several approaches to analyzing survival data from our study in terms of respective model assumptions. Methods: While both the Cox and Weibull survival regression models assume proportionality of the hazard functions over time, in many instances this assumption appears incompatible with the data at hand. Gray’s implementation of flexible models using penalized splines allows for a more realistic assessment of the covariate effects which may vary over time. Results: Gray’s model results revealed a steady decline in the age-adjusted intervention effect over time, which remained significant until about 2.7 years of follow-up. This was in contrast with the results obtained from the Cox and Weibull models which suggested an overall risk reduction due to intervention during the total follow-up of 6.7 years. Survival estimates based on the Cox and Gray models are shown for the two treatment groups and selected sample quantiles of the age distribution for illustration. Conclusions: Gray’s time-varying coefficients model facilitated a more realistic assessment of the intervention effect. Using suitable historical controls with MI history the effect of intervention was found to gradully diminish over time.