Miracle-dz/UniFAR-FTUs huggingface dataset:
Early‐stage breast cancer and employment participation after 2 years of follow‐up: A comparison with age‐matched controls

Although cancer survivors are more likely to be unemployed than individuals without a cancer history, employment participation after treatment of early‐stage breast cancer has not been widely studied to date. The objectives of the current study were to evaluate employment trajectories in a cohort of patients with early‐stage breast cancer and age‐matched controls from the time of diagnosis to the 2‐year follow‐up, and identify factors associated with diminished and emerging employment participation.
Protocol Reverse Engineering Using LDA and Association Analysis

Automatic protocol reverse engineering for application protocol is becoming more and more important for many applications such as application protocol analyzer, penetration testing, intrusion prevention and detection. However, many techniques for extracting the protocol message format specifications of unknown applications often have some limitations for little priori information or the time-consuming problem. In this paper, we present a method for automatically reverse engineering the protocol message formats of an application from its network trace, by using LDA and association analysis. The approach exploits the semantics of protocol messages without the executable code of application protocols, but focuses on the insight that the n-grams of protocol traces exhibit highly semantic information that can be leveraged for accurate protocol message format inference. Firstly, we propose the way to key words extract by utilizing the LDA model, secondly, the association analysis method is applied to constructing the feature words based on the above process. Lastly our experiments Show that the method can accurately infer message format specifications of SMTP text protocol.
Functional MRI-BOLD of visually triggered headache in patients with migraine.

BACKGROUND Spreading depression of Leao has been hypothesized as the basis for the visual aura of the migraine attack, supported by cerebral blood flow measurements of spreading hypoperfusion. The early depolarizing or activation phase of experimental spreading depression, however, is associated with a transient but pronounced cerebral blood flow increase that precedes spreading hypoperfusion. OBJECTIVE To study this early phase of the migraine attack, we investigated visually triggered attacks of headache and visual symptoms using a red-green checkerboard stimulus in patients with migraine. INTERVENTIONS We studied occipital cortex activation during visual stimulation by measuring occipital cortex perfusion with functional magnetic resonance imaging-blood oxygenation level-dependent contrast in 10 patients with migraine with aura and 2 patients with migraine without aura and 6 healthy subjects. RESULTS In 6 patients with migraine with aura and 2 patients with migraine without aura, their typical headache with (n = 2) or without visual change was visually triggered at 7.3 minutes (mean time) after visual stimulation began. In 5 of these patients, the onset of headache or visual change, or both, was preceded by suppression of initial activation (mean onset time, 4.3 minutes; P<.001) The suppression slowly propagated into contiguous occipital cortex at a rate ranging from 3 to 6 mm/ min. This neuronal suppression was accompanied by baseline contrast intensity increases that indicated vasodilatation and tissue hyperoxygenation. CONCLUSIONS We conclude that visually triggered headache and visual change in patients with migraine is accompanied by spreading suppression of initial neuronal activation and increased occipital cortex oxygenation. We postulate that this spreading suppression may be associated with initial activation of a migraine attack, independent of whether there are associated aura symptoms. We further postulate that there may be an association between vasodilation accompanying the initial stage of suppression and the induction of headache.
Solubilization and Upgrading of High Polyethylene Terephthalate Loadings in a Low-Costing Bifunctional Ionic Liquid.

The solubilization and efficient upgrading of high loadings of polyethylene terephthalate (PET) are important challenges, and most solvents for PET are highly toxic. Herein, a low-cost (ca. $1.2 kg-1 ) and biocompatible ionic liquid (IL), cholinium phosphate ([Ch]3 [PO4 ]), is demonstrated for the first time to play bifunctional roles in the solubilization and glycolytic degradation of PET. A high loading of PET (10 wt %) was readily dissolved in [Ch]3 [PO4 ] at relatively low temperatures (120 °C, 3 h) and under water-rich conditions. In-depth analysis of the solution revealed that high PET solubilization in [Ch]3 [PO4 ] could be ascribed to significant PET depolymerization. Acid precipitation yielded terephthalic acid as the dominant depolymerized monomer with a theoretical yield of approximately 95 %. Further exploration showed that in the presence of ethylene glycol (EG), the [Ch]3 [PO4 ]-catalyzed glycolysis of PET could efficiently occur with approximately 100 % conversion of PET and approximately 60.6 % yield of bis(2-hydroxyethyl)terephthalate under metal-free conditions. The IL could be reused at least three times without an apparent decrease in activity. NMR spectroscopy analysis revealed that strong hydrogen-bonding interactions between EG and the IL played an important role in the activation of EG and promotion of the glycolysis reaction. This study opens up avenues for exploring environmentally benign and efficient IL technology for solubilizing and recycling postconsumer polyester plastics.
Design and implementation of prototype service robot for shopping in a supermarket

This paper proposes a design and implementation of service robot for shopping in a supermarket, which accompanies customers and helps them to take the merchandises down from the shelf. And stop to answer the question from the customers during the patrolling in the mall. To create flexible interaction between customers and the service robot, graphic and verbal communications are investigated. Before the service scenario, the maps of the market are built through the simultaneous localization and mapping (SLAM) function with the position of merchandises obtained meanwhile. And the image features of merchandises are extracted by the recognition system. After receiving the request of grasping merchandises, service robot do path planning to optimize the moving distance during the task and grasp every object accurately. Further, to ensure the safety of customers, obstacle avoiding and emergency stop are investigated. With the proposed service robot system, a comfortable, efficient and labor saving market can be realized.
Influence of MMP inhibitor GM6001 loading of fibre coated polypropylene meshes on wound healing: Implications for hernia repair

Polypropylene meshes are standard for hernia repair. Matrix metalloproteinases play a central role in inflammation. To reduce the inflammatory response and improve remodelling with an associated reduction of hernia recurrence, we modified polypropylene meshes by nanofibre coating and saturation with the broad-spectrum matrix metalloproteinase inhibitor GM6001. The aim was to modulate the inflammatory reaction, increase collagen deposition and improve mesh biointegration. Polypropylene meshes were surface-modified with star-configured NCO-sP(EO-stat-PO) and covered with electrospun nanofibres (polypropylene-nano) and GM6001 (polypropylene-nano-GM). In a hernia model, defects were reconstructed with one of the meshes. Inflammation, neovascularization, bio-integration, proliferation and apoptosis were assessed histologically, collagen content and gelatinases biochemically. Mesh surface modification resulted in higher inflammatory response compared to polypropylene. Pro-inflammatory matrix metalloproteinase-9 paralleled findings while GM6001 reduced matrix metalloproteinase-9 significantly. Significantly increased matrix metalloproteinase-2 beneficial for remodelling was noted with polypropylene-nano-meshes. Increased vascular endothelial growth factor, neo-vascularization and collagen content were measured in polypropylene-nano-meshes compared to polypropylene. GM6001 significantly reduced myofibroblasts. This effect ended after d14 due to engineering limitations with release of maximal GM6001 loading. Nanofibre-coating of polypropylene-meshes confers better tissue vascularization to the cost of increased inflammation. This phenomenon can be only partially compensated by GM6001. Future research will enable higher GM6001 uptake in nano-coated meshes and may alter mesh biointegration in a more pronounced way.
An Improved PSO Algorithm for Interval Multi-Objective Optimization Systems

Considering an uncertain multi-objective optimization system with interval coefficients, this letter proposes an interval multiobjective particle swarm optimization algorithm. In order to improve its performance, a crowding distance measure based on the distance and the overlap degree of intervals, and a method of updating the archive based on the acceptance coefficient of decision-maker, are employed. Finally, results show that our algorithm is capable of generating excellent approximation of the true Pareto front. key words: interval, multi-objective, particle swarm, crowding distance
TMS affects moral judgment, showing the role of DLPFC and TPJ in cognitive and emotional processing

Decision-making involves a complex interplay of emotional responses and reasoning processes. In this study, we use TMS to explore the neurobiological substrates of moral decisions in humans. To examining the effects of TMS on the outcome of a moral-decision, we compare the decision outcome of moral-personal and moral-impersonal dilemmas to each other and examine the differential effects of applying TMS over the right DLPFC or right TPJ. In this comparison, we find that the TMS-induced disruption of the DLPFC during the decision process, affects the outcome of the moral-personal judgment, while TMS-induced disruption of TPJ affects only moral-impersonal conditions. In other words, we find a double-dissociation between DLPFC and TPJ in the outcome of a moral decision. Furthermore, we find that TMS-induced disruption of the DLPFC during non-moral, moral-impersonal, and moral-personal decisions lead to lower ratings of regret about the decision. Our results are in line with the dual-process theory and suggest a role for both the emotional response and cognitive reasoning process in moral judgment. Both the emotional and cognitive processes were shown to be involved in the decision outcome.
Top-k Relevant Semantic Place Retrieval on Spatial RDF Data

RDF data are traditionally accessed using structured query languages, such as SPARQL. However, this requires users to understand the language as well as the RDF schema. Keyword search on RDF data aims at relieving the user from these requirements; the user only inputs a set of keywords and the goal is to find small RDF subgraphs which contain all keywords. At the same time, popular RDF knowledge bases also include spatial semantics, which opens the road to location-based search operations. In this work, we propose and study a novel location-based keyword search query on RDF data. The objective of top-k relevant semantic places (kSP) retrieval is to find RDF subgraphs which contain the query keywords and are rooted at spatial entities close to the query location. The novelty of kSP queries is that they are location-aware and that they do not rely on the use of structured query languages. We design a basic method for the processing of kSP queries. To further accelerate kSP retrieval, two pruning approaches and a data preprocessing technique are proposed. Extensive empirical studies on two real datasets demonstrate the superior and robust performance of our proposals compared to the basic method.
Far-Red Light Detection in the Shoot Regulates Lateral Root Development through the HY5 Transcription Factor[OPEN]

Plants coordinate their response to above- and belowground competition when growing at high densities; a change in light quality detected by the shoot transmits a signal to adjust root development. Plants in dense vegetation compete for resources and detect competitors through reflection of far-red (FR) light from surrounding plants. This reflection causes a reduced red (R):FR ratio, which is sensed through phytochromes. Low R:FR induces shade avoidance responses of the shoot and also changes the root system architecture, although this has received little attention so far. Here, we investigate the molecular mechanisms through which light detection in the shoot regulates root development in Arabidopsis thaliana. We do so using a combination of microscopy, gene expression, and mutant study approaches in a setup that allows root imaging without exposing the roots to light treatment. We show that low R:FR perception in the shoot decreases the lateral root (LR) density by inhibiting LR emergence. This decrease in LR emergence upon shoot FR enrichment is regulated by phytochrome-dependent accumulation of the transcription factor ELONGATED HYPOCOTYL5 (HY5) in the LR primordia. HY5 regulates LR emergence by decreasing the plasma membrane abundance of PIN-FORMED3 and LIKE-AUX1 3 auxin transporters. Accordingly, FR enrichment reduces the auxin signal in the overlaying cortex cells, and this reduces LR outgrowth. This shoot-to-root communication can help plants coordinate resource partitioning under competition for light in high density fields.
Selective decline of neurotrophin and neurotrophin receptor genes within CA1 pyramidal neurons and hippocampus proper: Correlation with cognitive performance and neuropathology in mild cognitive impairment and Alzheimer's disease

Hippocampal CA1 pyramidal neurons, a major component of the medial temporal lobe memory circuit, are selectively vulnerable during the progression of Alzheimer's disease (AD). The cellular mechanism(s) underlying degeneration of these neurons and the relationship to cognitive performance remains largely undefined. Here, we profiled neurotrophin and neurotrophin receptor gene expression within microdissected CA1 neurons along with regional hippocampal dissections from subjects who died with a clinical diagnosis of no cognitive impairment (NCI), mild cognitive impairment (MCI), or AD using laser capture microdissection (LCM), custom‐designed microarray analysis, and qPCR of CA1 subregional dissections. Gene expression levels were correlated with cognitive test scores and AD neuropathology criteria. We found a significant downregulation of several neurotrophin genes (e.g., Gdnf, Ngfb, and Ntf4) in CA1 pyramidal neurons in MCI compared to NCI and AD subjects. In addition, the neurotrophin receptor transcripts TrkB and TrkC were decreased in MCI and AD compared to NCI. Regional hippocampal dissections also revealed select neurotrophic gene dysfunction providing evidence for vulnerability within the hippocampus proper during the progression of dementia. Downregulation of several neurotrophins of the NGF family and cognate neurotrophin receptor (TrkA, TrkB, and TrkC) genes correlated with antemortem cognitive measures including the Mini‐Mental State Exam (MMSE), a composite global cognitive score (GCS), and Episodic, Semantic, and Working Memory, Perceptual Speed, and Visuospatial domains. Significant correlations were found between select neurotrophic expression downregulation and neuritic plaques (NPs) and neurofibrillary tangles (NFTs), but not diffuse plaques (DPs). These data suggest that dysfunction of neurotrophin signaling complexes have profound negative sequelae within vulnerable hippocampal cell types, which play a role in mnemonic and executive dysfunction during the progression of AD.
Psychiatric symptom burden in older people living with HIV with and without cognitive impairment: the UCSF HIV over 60 cohort study

ABSTRACT Psychiatric comorbidities are common in people living with HIV (PLWH) and adversely affect life satisfaction, treatment adherence and disease progression. There are few data to inform the burden of psychiatric symptoms in older PLWH, a rapidly growing demographic in the U.S. We performed a cross-sectional analysis to understand the degree to which symptom burden was associated with cognitive disorders in PLWH over age 60. Participants completed a standardized neuropsychological battery and were assigned cognitive diagnoses using Frascati criteria. We captured psychiatric symptom burden using the Geriatric Depression Scale (GDS) and proxy-informed Neuropsychiatric Inventory-Questionnaire (NPI-Q). Those diagnosed with HIV-associated neurocognitive disorders (HAND, n = 39) were similar to those without HAND (n = 35) by age (median = 67 years for each group, p = 0.696), education (mean = 16 years vs. 17 years, p = 0.096), CD4+ T-lymphocyte counts (mean = 520 vs. 579, p = 0.240), duration of HIV (median = 21 years for each group, p = 0.911) and sex (92% male in HAND vs. 97% in non-HAND, p = 0.617). Our findings showed similarities in HAND and non-HAND groups on both NPI-Q (items and clusters) and GDS scores. However, there was a greater overall symptom burden in HIV compared to healthy elder controls (n = 236, p < 0.05), with more frequent agitation, depression, anxiety, apathy, irritability and nighttime behavior disturbances (p < 0.05). Our findings demonstrate no differences in psychiatric comorbidity by HAND status in older HIV participants; but confirm a substantial neurobehavioral burden in this older HIV-infected population.
Structured analysis, structured design, visual programming

The paper proposes a visual programming methodology based on the formalised dataflow diagram language PrM. The resulting approach seamlessly integrates all phases of information system development from early analysis to final implementation because the same visual language is applied throughout. The paper describes the PrM language and discusses visual programming in PrM based on menu selection of predefined graphical templates. The possibility of user-specified template types is considered. Generation of production code from visual PrM programs is explained, as well as prototype generation from unfinished specifications. The PrM language has been implemented, and the practicality of the proposed methodology is discussed in relation to this CASE tool. <<ETX>>
Surface Roughness and Topography of Poly(3-hydroxybutyrate-co-3- hydroxyvalerate) Influences Osteoblast Cell Growth

Osteoblast proliferation is sensitive to the topography of material surfaces. In this study, the proliferation of MC3T3 E1-S14 osteoblast cells on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) films with different surface characteristics was investigated. The solvent cast films were prepared using three different solvents/solvent mixtures; chloroform, DCM and a mixture of chloroform and acetone which produced PHBV films with both a rough (at the air interface) and smooth (at the glass interface) surface. Investigation of the surface characteristics by scanning electron and scanning probe microscopies revealed different surface topographies and degrees of surface roughness ranging from 20 to 200 nm. Mapping of the surface crystallinity index by micro-attenuated total reflectance Fourier transform infrared (ATR-FTIR) showed distinct variations in surface crystallinity between the different film surfaces. Water contact angles were significantly higher on the rough surface compared the smooth surface for a particular substrate, however, all surfaces were hydrophobic in nature (θA was in the range 69 - 80 degrees). MC3T3 E1-S14 osteoblast cells were cultured on the six different surfaces and proliferation was determined. After 2 days cell proliferation on all surfaces was significantly less than on the control substrate, however, after 4 days cell proliferation was optimal on the three surfaces that displayed the highest contact angle and the smallest crystallinity heterogeneity. In addition, the surface roughness and more specifically the surface topography influenced the proliferation of osteoblast cells on the PHBV film surface.
Air trapping in early cystic fibrosis lung disease—Does CT tell the full story?

Mosaic attenuation on expiratory chest computed tomography (CT) is common in early life cystic fibrosis (CF) and often referred to as “air trapping”. It is presumed to be localized hyperinflation due to small airway obstruction. In order to test this assumption, we compared air trapping extent to lung volumes measured on CT in young children with CF.
Phase-field modeling of defect nucleation and propagation in domains with material inhomogeneities

We present a phase-field approach that couples the representation of material heterogeneities with discontinuities in the displacement field to describe defects and damage evolution. This method in contrast to discrete models does not require topological changes in the mesh representation reducing the complexity in the implementation of the numerical simulation. Both defects and material inhomogeneities are described in terms of phase fields and their evolution and interaction follows from a set of analogous equations delivering a unified theory that couples the response of heterogeneous materials with displacement discontinuities seamlessly. We show the effectiveness of the model by predicting dislocation structures in a 3D periodic array of voids in nickel single crystal and the nucleation and evolution of crazes in polymethyl methacrylate.
Power Allocation Scheme for Non-Orthogonal Multiple Access in Underwater Acoustic Communications

In this paper, we propose a power allocation scheme for non-orthogonal multiple access (NOMA) in underwater acoustic sensor networks (UWASNs). The existing terrestrial sum-rate maximization (SRM) power allocation scheme suffers from the degradation of the overall sum-rate in UWASNs due to wasteful resource created by unequal transmission times between each transmission path. To address this issue, we propose the equal transmission times (ETT) power allocation scheme, which can prevent wasteful resource generation by guaranteeing equal transmission times between each transmission path. ETT considers the number of packets waiting for transmission in the sender’s buffer for creating equal transmission times. Numerical results show that the proposed ETT outperforms SRM in terms of the overall sum-rate, while having nearly identical maximum sum-rate to the SRMs.