Miracle-dz/UniFAR-FTUs huggingface dataset:
Frontline over ivory tower: key competencies in community-based curricula

Background The Royal College of Physicians and Surgeons of Canada mandates that community experiences be incorporated into medicine-based specialties. Presently there is wide variability in community endocrine experiences across Canadian training programs. This is complicated by the paucity of literature providing guidance on what constitutes a ‘community’ rotation. Method A modified Delphi technique was used to determine the CanMEDS competencies best taught in a community endocrinology curriculum. The Delphi technique is a qualitative-research method that uses a series of questionnaires sent to a group of experts with controlled feedback provided by the researchers after each survey round. The experts in this study included endocrinology program directors, community endocrinologists, endocrinology residents and recent endocrinology graduates. Results Thirty four out of 44 competencies rated by the panel were deemed suitable for a community curriculum. The experts considered the “Manager” role best taught in the community, while they considered the community least suitable to learn the “Medical Expert” competency. Conclusions To our knowledge, this is the first time the content of a community-based subspecialty curriculum was determined using the Delphi process in Canada. These findings suggest that community settings have potential to fill in gaps in residency training in regards to the CanMEDS Manager role. The results will aid program directors in designing competency-based community endocrinology rotations and competency-based community rotations in other medical subspecialty programs.
Interrelations between self‐efficacy and learning approaches: a developmental approach

Two major theoretical frameworks in educational psychology, namely student approaches to learning (SAL) and self‐efficacy have been used extensively to explain and predict students’ learning and academic achievement. There is a substantial body of research studies, for example, that documents the positive interrelations between individuals’ self‐efficacy beliefs and their approaches to learning. In particular, evidence ascertained from structural equation analyses suggests both a positive sense of academic self‐efficacy and deep learning approach combined to influence students’ academic achievement. More recently, albeit limited, research has focused on the study of developmental changes of these two constructs over time. As a contribution to this approach, we used latent growth curve modelling (LGM) to explore the initial states and trajectories of self‐efficacy and the two major learning approaches – surface and deep – over a two‐year period. Furthermore, we regressed both gender and academic experience as possible external correlates that could account for the change in the two theoretical frameworks. Two hundred and fifty‐two (116 females, 136 males) university students were administered Likert‐scale inventories on three occasions. SPSS AMOS showed a few major findings – notably, for example, the negative impact of academic experience on the change in self‐efficacy and the positive impact of academic experience on the initial states of self‐efficacy and surface learning approach.
Computational 3D Assembling Methods for DNA: A Survey

DNA encodes the genetic information of most living beings, except viruses that use RNA. Unlike other types of molecules, DNA is not usually described by its atomic structure being instead usually described by its base-pair sequence, i.e., the textual sequence of its subsidiary molecules known as nucleotides ( adenine (A), cytosine (C), guanine (G), and thymine (T)). The three-dimensional assembling of DNA molecules based on its base-pair sequence has been, for decades, a topic of interest for many research groups all over the world. In this paper, we survey the major methods found in the literature to assemble and visualize DNA molecules from their base-pair sequences. We divided these methods into three categories: predictive methods, adaptive methods, and thermodynamic methods . Predictive methods aim to predict a conformation of the DNA from its base pair sequence, while the goal of adaptive methods is to assemble DNA base-pairs sequences along previously known conformations, as needed in scenarios such as DNA Monte Carlo simulations. Unlike these two geometric methods, thermodynamic methods are energy-based and aim to predict secondary structural motifs of DNA in cases where hydrogen bonds between base pairs might be broken because of temperature changes. We also present the major software tools that implements predictive, adaptive, and thermodynamic methods.
Phrasal Graph-based Method for Abstractive Vietnamese Paragraph Compression

Text compression is the task of identifying the main information in the source text to form a short single sentence. A broad approach is to find a path containing common vertices in the word graph model. The first issue of this approach is that the path finding algorithm can separate words from the phrase expressing a content. This leads to create new sentences having different meaning from the original ones. The second issue is that when an information is expressed by different words or phrases, called co-reference situations. Due to lacking of mechanism for handling this situation, the compression will be missing information. We propose in this paper a method to overcome the above issues. The core of new method is the improved graph model in which each vertex illustrates a phrase with its corresponding Part-of-Speech label. The intersection vertices of branches are results of mechanism for handling co-references. The compressing algorithm reduces the graph and forms the final sentence. We use ROUGE measure to compare with two word graph-based baselines. The experiment result shows that our method creates short sentences containing rich information.
ENERGY PSYCHOLOGY-PRACTICES AND THEORIES OF NEW COMBINATIONS OF PSYCHOTHERAPY

Energy Psychology (EP) includes a spectrum of practices in which people tap on their bodies while focu sing their minds on problems they want to change. EP therapies often are very rapidly effective. This artic le examines varieties of explanations for how EP works, including: Cognitive changes, psychological conditioning, expectation effects, distraction tech niques, tapping on acupuncture points, shifts in ot her biological energies, wholistic healing, alternating stimulation of right and left sides of the body (p resumably producing alternating stimulation of left and right brain hemispheres) and nerve conduction speeds.
Interregional Coevolution Analysis Revealing Functional and Structural Interrelatedness between Different Genomic Regions in Human Mastadenovirus D

ABSTRACT Human mastadenovirus D (HAdV-D) is exceptionally rich in type among the seven human adenovirus species. This feature is attributed to frequent intertypic recombination events that have reshuffled orthologous genomic regions between different HAdV-D types. However, this trend appears to be paradoxical, as it has been demonstrated that the replacement of some of the interacting proteins for a specific function with other orthologues causes malfunction, indicating that intertypic recombination events may be deleterious. In order to understand why the paradoxical trend has been possible in HAdV-D evolution, we conducted an interregional coevolution analysis between different genomic regions of 45 different HAdV-D types and found that ca. 70% of the genome has coevolved, even though these are fragmented into several pieces via short intertypic recombination hot spot regions. Since it is statistically and biologically unlikely that all of the coevolving fragments have synchronously recombined between different genomes, it is probable that these regions have stayed in their original genomes during evolution as a platform for frequent intertypic recombination events in limited regions. It is also unlikely that the same genomic regions have remained almost untouched during frequent recombination events, independently, in all different types, by chance. In addition, the coevolving regions contain the coding regions of physically interacting proteins for important functions. Therefore, the coevolution of these regions should be attributed at least in part to natural selection due to common biological constraints operating on all types, including protein-protein interactions for essential functions. Our results predict additional unknown protein interactions. IMPORTANCE Human mastadenovirus D, an exceptionally type-rich human adenovirus species and causative agent of different diseases in a wide variety of tissues, including that of ocular region and digestive tract, as well as an opportunistic infection in immunocompromised patients, is known to have highly diverged through frequent intertypic recombination events; however, it has also been demonstrated that the replacement of a component protein of a multiprotein system with a homologous protein causes malfunction. The present study solved this apparent paradox by looking at which genomic parts have coevolved using a newly developed method. The results revealed that intertypic recombination events have occurred in limited genomic regions and been avoided in the genomic regions encoding proteins that physically interact for a given function. This approach detects purifying selection against recombination events causing the replacement of partial components of multiprotein systems and therefore predicts physical and functional interactions between different proteins and/or genomic elements.
Polymer‐Dispersed Bicontinuous Cubic Glycolipid Nanoparticles

We found that certain amphiphilic polymers such as PEO‐PPO‐PEO triblock copolymer (PL) can directly disperse a cubic glycolipid, 1‐O‐phytanyl‐β‐d‐xyloside (β‐XP), into bicontinuous cubic nanoparticles in water medium. The use of synchrotron small‐angle X‐ray diffraction (SSAXD) permitted the identification of the exact structure of these dispersed particles in the colloidal state. Dynamic light scattering method was used to obtain particle size distributions. The dispersion quality and the dispersion time can be improved by co‐dissolving the lipid and the polymer in a common solvent. The mean volume diameter of these dispersed colloidal particles depends on the mixing time and polymer concentration. About 5 wt % (0.18 mol %) of polymer to lipid weight was found to be sufficient to produce stable colloidal dispersions. At this polymer content and at 3 h of stirring time, the mean volume diameter of cubic colloidal particles was found to be 1.0 μm. Increase of dispersion time to 6 h reduced the colloidal particle size from 1.0 μm to 660 nm. At 3 h of mixing time, the increase of polymer content, from ∼5 to ∼10 wt %, reduced the particle mean diameter from 1.0 μm to 675 nm. Irrespective of these dispersion times and polymer contents, the dispersed colloidal particles exhibit predominately the Pn3m cubic phase structure, the same as that of a β‐XP‐water binary mixture, although a weak coexistence of Im3m cubic phase is identified in these colloidal particles. This coexistence is found to have the characteristics of a Bonnet relation, which forms convincing evidence for the infinite periodic minimal surface descriptions (IPMS). Considering the biotechnological significance, the preparation of these colloidal dispersions was carried out in a phosphate‐buffered saline (PBS) system. These cubic colloidal dispersions exhibited good stability and the cubic phase structure remained intact in the PBS system.
Application of Physiologically Based Pharmacokinetic Modeling to Understanding the Clinical Pharmacokinetics of UK-369,003

5-[2-Ethoxy-5-(4-ethyl-piperazine-1-sulfonyl)-pyridin-3-yl]-3-ethyl-2-(2-methoxy-ethyl)-2,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one (UK-369,003) is a phosphodiesterase-5 inhibitor in clinical development at Pfizer. UK-369,003 is predominantly metabolized by cytochrome P450 3A4 and is also a substrate for the efflux transporter P-glycoprotein. The pharmacokinetics of UK-369,003 has been profiled after oral administration of 1 to 800 mg of an immediate release formulation to healthy volunteers. Nonlinearity was observed in the systemic exposure at doses of 100 mg and greater. In addition, the pharmacokinetics of UK-369,003 has also been investigated after oral administration of the more therapeutically attractive modified release formulation. Systemic exposure was prolonged with the modified release formulation, but bioavailability was reduced in comparison with that of the immediate release formulation. Physiologically based pharmacokinetic modeling strategies are commonly used in drug discovery and development. This work describes application of the physiologically based pharmacokinetic software GastroPlus to understand the pharmacokinetics of UK-369,003. The impact of gut wall and hepatically mediated CYP3A4 metabolism, in addition to the actions of P-glycoprotein, in causing the nonlinear pharmacokinetics of the immediate release formulation and the reduced bioavailability of the modified release form, was investigated. The model accurately described the systemic exposure of UK-369,003 after intravenous and both immediate and modified release oral administration and suggested that CYP3A4 is responsible for the majority of the nonlinearity in systemic exposure observed after administration of the immediate release form. Conversely, the reduced bioavailability of the modified release formulation is believed to be caused by incomplete release from the device, incomplete absorption of released drug, and, to a lesser extent, CYP3A4 metabolism.
XML retrieval: what to retrieve?

The fundamental difference between standard information retrieval and XML retrieval is the unit of retrieval. In traditional IR, the unit of retrieval is fixed: it is the complete document. In XML retrieval, every XML element in a document is a retrievable unit. This makes XML retrieval more difficult: besides being relevant, a retrieved unit should be neither too large nor too small. The research presented here, a comparative analysis of two approaches to XML retrieval, aims to shed light on which XML elements should be retrieved. The experimental evaluation uses data from the Initiative for the Evaluation of XML retrieval (INEX 2002).
Racialized Topographies: Altitude and Race in Southern Cities*

This study examines altitudinal residential segregation by race in 146 cities in the U.S. South. It begins by embedding the topic in recent theorizations of the social construction of nature, the geography of race, and environmental justice. Second, it focuses on how housing markets, particularly in the South, tend to segregate minorities in low‐lying, flood‐prone, and amenity‐poor segments of urban areas. It tests empirically the hypothesis that blacks are disproportionately concentrated in lower‐altitude areas using gis to correlate race and elevation by digital elevation‐model block group within each city in 1990 and 2000. The statistical results confirm the suspected trend. A map of coefficients indicates strong positive associations in cities in the interior South‐where the hypothesis is confirmed‐and an inverse relationship near the coast, where whites dominate higher‐valued coastal properties. Selected city case studies demonstrate these relationships connecting the broad dynamics of racial segregation to the particularities of individual places.
A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer’s disease

Objective: To investigate whether or not a coding polymorphism in the cystatin C gene (CST3) contributes risk for AD. Design: A case-control genetic association study of a Caucasian dataset of 309 clinic- and community-based cases and 134 community-based controls. Results: The authors find a signficant interaction between the GG genotype of CST3 and age/age of onset on risk for AD, such that in the over-80 age group the GG genotype contributes two-fold increased risk for the disease. The authors also see a trend toward interaction between APOE ε4-carrying genotype and age/age of onset in this dataset, but in the case of APOE the risk decreases with age. Analysis of only the community-based cases versus controls reveals a significant three-way interaction between APOE, CST3 and age/age of onset. Conclusion: The reduced or absent risk for AD conferred by APOE in older populations has been well reported in the literature, prompting the suggestion that additional genetic risk factors confer risk for later-onset AD. In the author’s dataset the opposite effects of APOE and CST3 genotype on risk for AD with increasing age suggest that CST3 is one of the risk factors for later-onset AD. Although the functional significance of this coding polymorphism has not yet been reported, several hypotheses can be proposed as to how variation in an amyloidogenic cysteine protease inhibitor may have pathologic consequences for AD.
THE EMPIRICAL EIGENVALUE DISTRIBUTION OF A GRAM MATRIX: FROM INDEPENDENCE TO STATIONARITY

Consider a N × n matrix Zn = (Zn j1j2 ) where the individual entries are a realization of a properly rescaled stationary gaussian random field: Z j1j2 = 1 √ n ∑ (k1,k2)∈Z2 h(k1, k2)U(j1 − k1, j2 − k2), where h ∈ `1(Z2) is a deterministic complex summable sequence and (U(j1, j2); (j1, j2) ∈ Z2) is a sequence of independent complex gaussian random variables with mean zero and unit variance. The purpose of this article is to study the limiting empirical distribution of the eigenvalues of Gram random matrices such as ZnZ∗ n and (Zn + An)(Zn + An) ∗ where An is a deterministic matrix with appropriate assumptions in the case where n → ∞ and N n → c ∈ (0,∞). The proof relies on related results for matrices with independent but not identically distributed entries and substantially differs from related works in the literature (Boutet de Monvel et al. [3], Girko [7], etc.).
Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo.

BACKGROUND Dopamine is a potent neuromodulator in the brain, influencing a variety of motivated behaviors and involved in several neurologic diseases. Measurements of extracellular dopamine in the brains of experimental animals have traditionally focused on a tonic timescale (minutes to hours). However, dopamine concentrations are now known to fluctuate on a phasic timescale (subseconds to seconds). APPROACH Fast-scan cyclic voltammetry provides analytical chemical measurements of phasic dopamine signals in the rat brain. CONTENT Procedural aspects of the technique are discussed, with regard to appropriate use and in comparison with other methods. Finally, examples of data collected using fast-scan cyclic voltammetry are summarized, including naturally occurring dopamine transients and signals arising from electrical stimulation of dopamine neurons. SUMMARY Fast-scan cyclic voltammetry offers real-time measurements of changes in extracellular dopamine concentrations in vivo. With its subsecond time resolution, micrometer-dimension spatial resolution, and chemical selectivity, it is the most suitable technique currently available to measure transient concentration changes of dopamine.
Online Bipartite Matching with Amortized O(log 2 n) Replacements

In the online bipartite matching problem with replacements, all the vertices on one side of the bipartition are given, and the vertices on the other side arrive one-by-one with all their incident edges. The goal is to maintain a maximum matching while minimizing the number of changes (replacements) to the matching. We show that the greedy algorithm that always takes the shortest augmenting path from the newly inserted vertex (denoted the SAP protocol) uses at most amortized O(log 2 n) replacements per insertion, where n is the total number of vertices inserted. This is the first analysis to achieve a polylogarithmic number of replacements for any replacement strategy, almost matching the Ω (log n) lower bound. The previous best strategy known achieved amortized O(√ n) replacements [Bosek, Leniowski, Sankowski, Zych, FOCS 2014]. For the SAP protocol in particular, nothing better than the trivial O(n) bound was known except in special cases. Our analysis immediately implies the same upper bound of O(log 2 n) reassignments for the capacitated assignment problem, where each vertex on the static side of the bipartition is initialized with the capacity to serve a number of vertices. We also analyze the problem of minimizing the maximum server load. We show that if the final graph has maximum server load L, then the SAP protocol makes amortized O(min { L log2 n , √ nlog n}) reassignments. We also show that this is close to tight, because Ω (min { L, √ n}) reassignments can be necessary.
MultiBIC: an improved speaker segmentation technique for TV shows

Speaker segmentation systems usually have problems detecting short segments, which causes the number of deletions to be high and therefore harming the performance of the system. This is a complication when it comes to segmenting multimedia information such as movies and TV shows, where dialogs among characters are very common. In this paper a modification of the BIC algorithm is presented, which will reduce remarkably the number of deletions without causing an increase in the number of false alarms. This modification, referred to as MultiBIC, assumes that two change-points are present in a window of data, while conventional BIC approach supposes that there is just one. This causes the system to notice when there is more than one change-point in a window, finding shorter segments than traditional BIC.
CRUSH: Controlled, Scalable, Decentralized Placement of Replicated Data

Emerging large-scale distributed storage systems are faced with the task of distributing petabytes of data among tens or hundreds of thousands of storage devices. Such systems must evenly distribute data and workload to efficiently utilize available resources and maximize system performance, while facilitating system growth and managing hardware failures. We have developed CRUSH, a scalable pseudorandom data distribution function designed for distributed object-based storage systems that efficiently maps data objects to storage devices without relying on a central directory. Because large systems are inherently dynamic, CRUSH is designed to facilitate the addition and removal of storage while minimizing unnecessary data movement. The algorithm accommodates a wide variety of data replication and reliability mechanisms and distributes data in terms of user-defined policies that enforce separation of replicas across failure domains
On relaxed LMI-based designs for fuzzy regulators and fuzzy observers

Relaxed conditions for the stability study of nonlinear, continuous systems given by fuzzy models are presented. A theoretical analysis shows that the proposed method provides better or at least the same results of the methods presented in the literature. Digital simulations exemplify this fact. These results are also used for the fuzzy regulators and observers design. The nonlinear systems are represented by the fuzzy models proposed by Takagi and Sugeno. The stability analysis and the design of controllers are described by LMIs (Linear Matrix Inequalities), that can be solved efficiently by convex programming techniques. The specification of the decay rate, constraints on control input and output are also described by LMIs. Finally, the proposed design method is applied in the control of an inverted pendulum.