Miracle-dz/UniFAR-FTUs huggingface dataset:
A Systematic Investigation into Aging Related Genes in Brain and Their Relationship with Alzheimer’s Disease

Aging, as a complex biological process, is accompanied by the accumulation of functional loses at different levels, which makes age to be the biggest risk factor to many neurological diseases. Even following decades of investigation, the process of aging is still far from being fully understood, especially at a systematic level. In this study, we identified aging related genes in brain by collecting the ones with sustained and consistent gene expression or DNA methylation changes in the aging process. Functional analysis with Gene Ontology to these genes suggested transcriptional regulators to be the most affected genes in the aging process. Transcription regulation analysis found some transcription factors, especially Specificity Protein 1 (SP1), to play important roles in regulating aging related gene expression. Module-based functional analysis indicated these genes to be associated with many well-known aging related pathways, supporting the validity of our approach to select aging related genes. Finally, we investigated the roles of aging related genes on Alzheimer’s Disease (AD). We found that aging and AD related genes both involved some common pathways, which provided a possible explanation why aging made the brain more vulnerable to Alzheimer’s Disease.
Two Decades of Research on Teacher Expectations: Findings and Future Directions

Good discusses the types of teacher expectation effects evi denced in the classroom. Particular attention is focused on the research that addresses teachers' expectations for and interac tions with individuals believed to be of high or low potential. Good presents a model for use in understanding the dynamics of expectation communication in the classroom and highlights numerous studies relating teacher expectations with student behavior. The differential treatment of students by teachers is described by the author, with special attention given to how teachers express low expectations. The article concludes with a description of future research directions.
Closed‐loop controlled administration of propofol using bispectral analysis

Ten patients, undergoing elective orthopaedic surgery under spinal anaesthesia, were sedated with propofol using a closed‐loop feedback control system. The bispectral index (BIS), a new processed EEG parameter, was used as control variable. Propofol administration was controlled by a patient individualised adaptive model‐based controller incorporating target‐controlled infusion technology combined with a pharmacokinetic‐dynamic model. This feedback control system for propofol administration proved to be adequate and safe. BIS was found to be well suited as control variable.
Panel: empirical validation: what, why, when, and how

Robert J. Walker (Chair)University of CalgaryCalgary, Canadarwalker@cpsc.ucalgary. caLionel C. BriandCarleton UniversityOttawa, Canadabriand@sce.carleton. caDavid NotkinUniversity of WashingtonSeattle, USAnotkin@cs.washington. eduCarolyn B. SeamanUniversity of Maryland, Baltimore CountyBaltimore, USAcseaman@umbc.eduWalter F. TichyUniversitat Karlsruhe¨Karlsruhe, Germanytichy@ira.uka. de
Moderating effects of gender and age on the relationship between self-esteem and life satisfaction in mainland Chinese

Previous studies indicated that not only individual self-esteem (e.g., Diener & Diener, 1995; Neto, 1993) but also collective self-esteem (e.g., Crocker, Luhtanen, Blaine, & Broadnax, 1994; Zhang & Leung, 1999) contributed to prediction of life satisfaction. When the effects of individual and collective self-esteems on life satisfaction have been demonstrated, a further question in life satisfaction research is that whether the relationship between self-esteem and life satisfaction is subject to the influence of boundary conditions. The present investigation focused on moderating effects of gender and age on the relationship between self-esteem and life satisfaction in Chinese people. Participants were 1347 Mainland Chinese (aged from 14 to 88 years, 52.3% female) from three generations. They finished the General Life Satisfaction Scale (Leung & Leung, 1992), Life Domain Satisfaction Scale (revised from Michalos, 1985), Self-Esteem Scale (Rosenberg, 1965) and Collective Self-Esteem Scale (Luhtanen & Crock.
Modeling and synthesis of communication subsystems for loop accelerator pipelines

The communication synthesis for data transfer and synchronization between loop accelerators is a major challenge in streaming applications. The complexity of the problem arises from the fact that optimal memory mapping and address generation in communication subsystems for parallel data access and out-of-order communication depend on tiling and scheduling choices. This paper solves the problem of communication synthesis by leveraging the windowed synchronous data flow (WSDF) model for communication synthesis. In this context, an intermediate representation of communicating loops in the polyhedral model and a unified methodology for their projection onto the WSDF model is proposed. Finally, we present the architecture template, synthesis methodology, and overhead of the communication primitive.
A simulation of bacterial communities

This study constructs and tests an agent-based model of bacterial communities with the goal of modeling the observation that the majority of bacteria in nature cannot be cultured. The new field of metagenomics, the direct, mass sequencing of DNA recovered from the environment, is the source of this observation. The hypothesis tested is that bacteria form interdependent communities so that viable levels of energy production are rare in bacteria when they are grown in monoculture. A new game, the metabolism game is introduced. Agents produce energy by playing this game with one another. Studies are run with different number of bacterial species in the simulation. The energy level for viability is set by running simulations with a single bacterial species and then the hypothesis is tested in simulations with multiple bacterial species. Multiple bacterial species are evolved in a novel type of multi-population evolutionary algorithm called a multiple worlds algorithm. The fraction of culturable bacterial agents recovered from the simulation is larger than that found in nature but still quite low, supporting the hypothesis that bacteria may not be culturable because they require the presence of partner species.
Juquitiba-like Hantavirus from 2 Nonrelated Rodent Species, Uruguay

Serologic and genetic analyses indicate that a Juquitiba-like hantavirus circulates in Maldonado, Uruguay. This virus is carried by 2 rodent species, Oligoryzomys nigripes and Oxymycterus nasutus. The same hantavirus in 2 nonrelated species can be explained by a spillover infection or a host-switching event.
Chinese Responses to Modernization: A Psychological Analysis

In the last one hundred plus years, China, under the impact of modernization, has undergone the most significant change in the past 5,000 years. Modernization is a continuous process of protest and change. At each stage of modernization, outcomes may be regarded as the result of complex strategies and responses to those demands. This paper will address the strategies and responses that Chinese have adopted in their attempt to deal with the pressure and challenge of modernization. As a background to understanding these strategies and responses, the following four perspectives will be delineated. First, my perspective is mainly at the micro level, but I will occasionally shift to the macro level when needed. Second, my analyses will largely rely on results from empirical research. They will be supplemented by daily-life observations and appropriate conceptual or theoretical analyses. Third, Chinese intellectuals have been playing a guiding role of enlightenment, criticism, and promotion and their responses have been influential in formulating, directing, or channeling the views of the general public. A comprehensive analysis of relevant ideologies and strategies endorsed by Chinese intellectuals will be provided. Finally, the analysis of Chinese responses to modernization will be based upon the relevant literature from all the three major Chinese societies (Taiwan, Hong Kong, and mainland China). In addition, this paper will clarify the basic modes and specific mechanisms of adaptation to drastic environmental changes. They will be applied as conceptual tools for the analysis of Chinese intellectuals’ ideological responses to modernization and psychological processes involved in accommodating cognitive and behavioral changes in their daily lives.
Burnout and self‐employment: a cross‐cultural empirical study

This study examined the differences between full-time self-employed and organizationally employed individuals in Canada (n = 248) and Pakistan (n = 306) in terms of overall burnout and its three dimensions (emotional exhaustion, depersonalization and lack of accomplishment), turnover intentions and non-work satisfaction. Data were collected by means of a structured questionnaire from Canadian employees in Montreal and Pakistani employees in Lahore. One-way analysis of variance and multivariate analysis of variance were used to analyse the data. The self-employed reported significantly higher overall burnout, emotional exhaustion, lack of accomplishment, non-work satisfaction and turnover intention than the organizationally employed in both countries. No significant differences were found between self-employed and organizationally employed in terms of depersonalization in both countries. Results are discussed in light of previous empirical evidence on self-employment and the quality of work and non-work life from cross-cultural perspectives. Copyright © 2007 John Wiley & Sons, Ltd.
A probabilistic approach based on Random Forests to estimating similarity of human motion in the context of Parkinson's Disease

The objective characterization of human motion is required in a variety of fields including competitive sports, rehabilitation and the detection of motor deficits. Nowadays, typically human experts evaluate the motor behavior. These evaluations are based on their individual experience which leads to a low inter- and intra-expert reliability. Standardized tests improve on the reliability but are still prone to subjective ratings and require human expert knowledge. This paper presents a novel method to characterize the motor state of Parkinson patients using full body motion capturing data based on a combination of multiple metrics. Our approach merges various metrics with a Random Forest and uses a probabilistic formulation to compute a one-dimensional measure for the performed motion. We present an application of our approach to the problem of relating subject motion to different classes like healthy subjects and Parkinson disease patients with deep brain stimulation switched on or off. In the experimental session we show that our measure leads to high classification rates and high entropy values for real-world data. Besides, we show that our method discriminates between Parkinson's subjects (with and without stimulation) and healthy persons as good as the Unified Parkinson's Disease Rating Scale (UPDRS).
Single Particle Electron Microscopy Analysis of the Bovine Anion Exchanger 1 Reveals a Flexible Linker Connecting the Cytoplasmic and Membrane Domains

Anion exchanger 1 (AE1) is the major erythrocyte membrane protein that mediates chloride/bicarbonate exchange across the erythrocyte membrane facilitating CO2 transport by the blood, and anchors the plasma membrane to the spectrin-based cytoskeleton. This multi-protein cytoskeletal complex plays an important role in erythrocyte elasticity and membrane stability. An in-frame AE1 deletion of nine amino acids in the cytoplasmic domain in a proximity to the membrane domain results in a marked increase in membrane rigidity and ovalocytic red cells in the disease Southeast Asian Ovalocytosis (SAO). We hypothesized that AE1 has a flexible region connecting the cytoplasmic and membrane domains, which is partially deleted in SAO, thus causing the loss of erythrocyte elasticity. To explore this hypothesis, we developed a new non-denaturing method of AE1 purification from bovine erythrocyte membranes. A three-dimensional (3D) structure of bovine AE1 at 2.4 nm resolution was obtained by negative staining electron microscopy, orthogonal tilt reconstruction and single particle analysis. The cytoplasmic and membrane domains are connected by two parallel linkers. Image classification demonstrated substantial flexibility in the linker region. We propose a mechanism whereby flexibility of the linker region plays a critical role in regulating red cell elasticity.
Statistical modeling of PLC-to-DSL interference

This contribution presents a new results on the statistical characterization of PLC-to-DSL interference. The frequency-dependent couplings between power line cables and twisted-pair were estimated from measurements on a large number of residential inside wires. A parametric statistical model based on a mixture of two truncated Gaussian distributions is then set forth. The proposed statistical model allows the statistical evaluation of the impact of broadband PLC (BB-PLC) interference on various DSL technologies. To the best of the Authors' knowledge, this is the first statistical model for PLC-to-DSL interference to be proposed.
Autonomous WiFi Sensor for Heating Systems in the Internet of Things

In smart cities and home applications, the use of Wireless Sensor Networks to extract environmental data becomes more common with the passing of time. These sensors are used for a wide array of applications, but mainly to manage energy consumption in domestic buildings. One of the key energy consumers in households is heating systems. To monitor them, sensors are used with wireless communication protocols, like ZigBee, to transmit data to a central processing unit (CPU). WiFi communications, on the contrary, are rarely seen in these implementations due to its high energy consumption, although almost in every home one can find such networks. Yet, with the Internet of Things (IoT), new revisions of the standard have arisen which enable this technology for wireless sensing. To validate this theory and fill a technological necessity, this proposal is presented. In this work, the design and implementation of an autonomous WiFi sensor, paired with thermoelectric energy harvesting, are presented as an IoT solution for monitoring heating devices. For this, a thorough analysis of the proposed architecture is presented. Tests regarding energy consumption and generation, efficiency, and real world scenario trials are done. Finalizing, a comparison between the obtained results and current implementations is shown.
Predicting News Reader Preferences

Pulse provided a month of data for 1000 users. The data contains all stories published during August 2011 and all the user reads and clickthroughs in the same month. A read is defined as the user’s first click on a story. Depending on the feed, this leads to a page showing anything from a short blurb to the full text of the story. The user then has the option for a clickthrough, which shows the original story in a browser. The dataset contained the following information on each story, in a tab-delimited text file with one story per line: • URL. • Title. • Feed name and feed URL. • Timestamp of the story’s first read. The stories were keyed on (story URL, feed URL). The files of user reads and clickthroughs contains of the above, plus the ID of the user doing the read or clickthrough. The timestamp refers to the date and time of the user’s read.
Conscientiousness and Agreeableness as Moderators of the Relationship between Neuroticism and Counterproductive Work Behaviors: A Constructive Replication

Several previous studies examining the predictors of counterproductive work behaviors (CWBs) have found positive relationships for neuroticism and negative relationships for conscientiousness and agreeableness. We extend this research by examining whether employee personality traits interact with each other to influence CWBs. Because conscientiousness and agreeableness may suppress one's tendency to engage in CWBs, we hypothesized that the neuroticism–CWB relationship will be weaker among workers who are high in either conscientiousness or agreeableness than among workers who are low in these traits. Data from three independent samples provide support for these hypothesized moderator effects.
Dramatic changes in muscle contractile and structural properties after 2 botulinum toxin injections

Introduction: Botulinum toxin is frequently administered serially to maintain therapeutic muscle paralysis, but the effect of repeated doses on muscle function are largely unknown. This study characterized the muscle response to 2 onabotulinum toxin (BoNT) injections separated by 3 months. Methods: Animal subjects received a single toxin injection (n = 8), 2 BoNT injections separated by 3 months (n = 14), or 1 BoNT and 1 saline injection separated by 3 months (n = 8). Results: The functional effect of 2 serial injections was exponentially greater than the effect of a single injection. While both groups treated with a single BoNT injection had decreased torque in the injected leg by approximately 50% relative to contralateral legs, the double BoNT injected group had decreased torque by over 95% relative to the preinjection level. Both single and double BoNT injections produced clear signs of fiber‐type grouping. Conclusions: These experiments demonstrate a disproportionately greater effect of repeated BoNT injections. Muscle Nerve 52: 649–657, 2015
PUBLIC CONCERN FOR ENVIRONMENTAL POLLUTION

The spring of 1970 was a milestone in the effort to increase public awareness of environmental problems. During this period, the nation's attention was increasingly drawn to pollution and other threats to the environment. A dozen special television broadcasts examined the issue, while numerous magazines picked up the theme, and environmental groups were formed in an attempt to coordinate local conservation efforts, and extend their concern to the entire community. A climax was reached on April 22, when communities across the nation were urged to observe Earth Day. If it is clear that public opinion was a principal target of all these efforts, it is less clear just how much of the intended message has gotten across, and what other factors have affected public concern for the environment. Some answer to these questions is provided by the results of a recent survey of public opinion in Durham, North Carolina. In late March, 197o, questionnaires were distributed to a random sample of some 300 Durham residents, and nearly threefourths of these were completed and returned. ' The survey dealt with the issue of environmental damage on several different levels, and aimed at discovering how aware people were of this problem, who or what they felt was responsible for it, and how it might be solved.
Quantitative Analysis of Mitochondrial Ca2+ Uptake and Release Pathways in Sympathetic Neurons

Rate equations for mitochondrial Ca2+ uptake and release and plasma membrane Ca2+ transport were determined from the measured fluxes in the preceding study and incorporated into a model of Ca2+ dynamics. It was asked if the measured fluxes are sufficient to account for the [Ca2+]i recovery kinetics after depolarization-evoked [Ca2+]i elevations. Ca2+ transport across the plasma membrane was described by a parallel extrusion/leak system, while the rates of mitochondrial Ca2+ uptake and release were represented using equations like those describing Ca2+ transport by isolated mitochondria. Taken together, these rate descriptions account very well for the time course of recovery after [Ca2+]i elevations evoked by weak and strong depolarization and their differential sensitivity to FCCP, CGP 37157, and [Na+]i. The model also leads to three general conclusions about mitochondrial Ca2+ transport in intact cells: (1) mitochondria are expected to accumulate Ca2+ even in response to stimuli that raise [Ca2+]i only slightly above resting levels; (2) there are two qualitatively different stimulus regimes that parallel the buffering and non-buffering modes of Ca2+ transport by isolated mitochondria that have been described previously; (3) the impact of mitochondrial Ca2+ transport on intracellular calcium dynamics is strongly influenced by nonmitochondrial Ca2+ transport; in particular, the magnitude of the prolonged [Ca2+]i elevation that occurs during the plateau phase of recovery is related to the Ca2+ set-point described in studies of isolated mitochondria, but is a property of mitochondrial Ca2+ transport in a cellular context. Finally, the model resolves the paradoxical finding that stimulus-induced [Ca2+]i elevations as small as ∼300 nM increase intramitochondrial total Ca2+ concentration, but the steady [Ca2+]i elevations evoked by such stimuli are not influenced by FCCP.
Personalized Diagnosis and Repair of Customer Requirements in Constraint-based Recommendation

Constraint-based recommender applications derive interesting products and services from large and potentially complex item sets. If such applications cannot find a solution, repair actions are proposed that provide support for getting out of the so-called “no solution could be found” dilemma. Such repairs are not personalized and thus often cause a low level of satisfaction and cancellations of sessions. In this work we introduce a personalized repair algorithm that integrates the concepts of model-based diagnosis with collaborative recommendation approaches. For demonstration purposes, we present the results of a study that show improvements in prediction accuracy when personalized repair actions are proposed.
Pseudopowers and primality proving

It has been known since the 1930s that so-called pseudosquares yield a very powerful machinery for the primality testing of large integers N. In fact, assuming reasonable heuristics (which have been confirmed for numbers to 2^80) this gives a deterministic primality test in time O((lg N)^(3+o(1))), which many believe to be best possible. In the 1980s D.H. Lehmer posed a question tantamount to whether this could be extended to pseudo r-th powers. Very recently, this was accomplished for r=3. In fact, the results obtained indicate that r=3 might lead to an even more powerful algorithm than r=2. This naturally leads to the challenge if and how anything can be achieved for r>3. The extension from r = 2 to r = 3 relied on properties of the arithmetic of the Eisenstein ring of integers Z[\zeta_3], including the Law of Cubic Reciprocity. In this paper we present a generalization of our result for any odd prime r. The generalization is obtained by studying the properties of Gaussian and Jacobi sums in cyclotomic ring of integers, which are tools from which the r-th power Eisenstein Reciprocity Law is derived, rather than from the law itself. While r=3 seems to lead to a more efficient algorithm than r=2, we show that extending to any r>3 does not appear to lead to any further improvements.
Dynamic label sampling on fisheye maps for information exploration

For data with large dimensionality, placing labels is critical for users' comprehension of a scatterplot or a map of items. We propose a dynamic label sampling technique that, combined with graphical fisheye views, selects appropriate labels out of a large set of items on a map. Labels are sampled to give focus and contextual information according to users' panning/zooming and filtering operation. The paper also demonstrates an example of visual exploration with the image browser based on our technique.