Miracle-dz/UniFAR-FTUs huggingface dataset:
Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long‐term ethanol administration

Acetaldehyde and the lipid peroxidation‐derived aldehyde malondialdehyde (MDA), are reactive compounds that are generated during ethanol metabolism in the liver, and both aldehydes have been shown to be capable of binding to proteins and forming stable adducts. Because similar concentrations of MDA and acetaldehyde can coexist in the liver during ethanol oxidation, protein adduct formation in the presence of both of these aldehydes was studied under both in vitro and in vivo conditions. When proteins were incubated in the presence of both MDA and acetaldehyde, MDA caused a marked and concentration‐dependent increase in the stable binding of acetaldehyde to proteins. Maximum stimulation of binding occurred at approximately a fourfold molar excess of MDA relative to acetaldehyde when concentrations of 1.0 mmol/L and 0.1 mmol/L were tested. The formation of highly fluorescent product or products was associated with the MDA stimulation of acetaldehyde binding, indicating that new and distinct products were being generated. These hybrid adducts of MDA and acetaldehyde have been designated as MAA adducts. An affinity‐purified polyclonal antibody was produced that specifically recognized MAA epitopes on proteins and did not cross‐react with carrier proteins or proteins modified with either acetaldehyde or MDA alone. A quantitative competitive enzyme‐linked immunosorbent assay (ELISA) was developed and detected the presence of MAA‐modified proteins in liver cytosol from ethanol‐fed rats but not in pair‐fed controls. Quantification of the data from the competitive ELISA indicated the presence of approximately 75 pmoles protein‐bound MAA per milligram liver cytosol proteins of the ethanol‐fed animals. These results indicate that acetaldehyde and MDA can react together in a synergistic manner and generate hybrid adducts (MAA‐adducts) and further suggest that MAA adducts may represent a major species of adducts formed in the liver during ethanol metabolism in vivo.
1 INSTRUMENTAL AND HUMANISTIC VALUES IN THE MANAGEMENT OF PEOPLE : A Seven Nation Study Communication

The nature of the value which is attached to people may be an important component of national culture. In the context of work organizations, this may affect the legitimacy and effectiveness of transferring people management practices from one country to another. This may be particularly the case in ‘non-western’ emerging economies which are increasingly coming into contact with western human resource management practices. It is proposed that a major difference in the locus of human value is between an instrumental view of people as a means to an end, and a humanistic view of people as an end in themselves. The exploratory study reported in this paper of managers in seven diverse countries, seeks to investigate the nature and implications of these two loci of human value. In particular, it discovers significant differences among countries which may have implications for future research, as well as people management practices across cultures.
Inter-regional mobility in Europe: a note on the cross-country evidence

This paper uses data on 11 EU countries to explain cross-national differences in internal migration rates. It is found that 89% of the variance in gross migration in current member states can be explained by variations in employment protection, international migration, the share of ownership occupied housing and the average region size of a country. Results concerning net migration rates suggest that although disparities in unemployment are important determinants of net migration, so are employment protection, long-term unemployment and the share of owner occupied housing.
Comparing the performances of least mean squares based multirate adaptive filters

In this study, sign-error, sign-data, and sign-sign modifications of the multirate least mean squares (LMS) filter are proposed as an alternative to the existing multirate LMS and normalized LMS filters for reconstructing the high rate desired signal from its several low rate noisy observations. The performance of all the existing and the proposed methods are compared by using an adaptive noise cancellation simulation example applied to an audio signal. It is seen from the simulation results that some of the proposed methods lead to better results than the existing ones especially in the convergence speed sense.
DECISION-MAKING SUPPORT IN HUMAN RESOURCE MANAGEMENT BASED ON MULTI-OBJECTIVE OPTIMIZATION

The objective of this research is to develop a methodological approach to making managerial decisions in human resource management tasks. The paper substantiates the expedience of using multi-objective optimization, based on the Technique for Order of Preference by Similarity to Ideal Solution, to (or “intending to”) improving the efficiency and transparency of human resource management decisions. A modified Technique is suggested to ensure the adaptability of multi-criteria decision-making in human resource management tasks. This modification consists in the integration of additional components into the decision algorithm. The method was tested during the solution of the real problem of selecting the best candidate among the applicants for the vacancies at the State Oil Company of the Azerbaijan Republic Human Resource Management Department. The results of the experiment showed the practical applicability and efficiency of the suggested approach for the objective and adequate evaluation of professional, qualification, and personal qualities of applicants, and for the support of managers during decision-making in the selection of personnel by the long-term tasks of the organization.
Mosquito Transposable Elements and piwi Genes

Vector control is an essential and effective approach for controlling transmission of vector-borne diseases. However, increasing resistance to insecticide and drugs suggests that new strategies to control vector-borne diseases are needed. One possible strategy involves replacing mosquito populations with diseaseresistant transgenic mosquitoes. Transposable elements (TEs) are an important component in this new strategy due to their ability to integrate exogenous DNA into chromosomes. They could potentially be useful tools in assisting the spread of disease-resistant genes in mosquito populations. This research focuses on two related subjects, TEs and their regulation. The first subject is on a Long Terminal Repeat (LTR) retrotransposon in the African malaria mosquito, Anopheles gambiae, namely Belly. The second subject focuses on the characterization of piwi genes in the dengue and yellow fever mosquito, Aedes aegypti. For the first subject we characterized Belly by identifying the two identical LTRs and one intact open reading frame. We also defined the target site duplications and boundaries of the full-length Belly element. This novel retrotransposon has nine full-length copies in the An. gambiae sequenced genome and their nucleotide similarity suggests that there has been fairly recent retrotransposon. We have shown that Belly is transcribed and translated in An. gambiae. Single LTR circles were recovered from An. gambiae cells, which is consistent with active transposition of Belly.
Deep Interactive Evolutionary Computation

This short paper outlines our ongoing work in combining generative adversarial networks (GANs) with interactive evolution. While GANs can be trained to produce lifelike images, they sample randomly from the learned distribution, providing no control over the results. Interactive evolution has been used to create various artifacts such as images, music and 3D objects, but relies on having a good evolvable representation of the target domain. We use the trained generator part of a GAN as genotype-to-phenotype mapping, allowing for controllable high-quality image generation.
BLIND AND AFTERMATH NUMERICAL ANALYSES OF SUPERCRITICAL WATER FLOW AND HEAT TRANSFER IN 1 / 12 OF 7-ROD BUNDLE WITH SPACERS

Application of supercritical water to conventional power plants has provided nuclear community with some experience which can be used in development of future generation of nuclear power plants. Nevertheless there are some specific features of nuclear power plants which should be studied during preparations of pilot designs. In 2013, the Gen-IV International Forum initiated a numerical benchmark based on experimental data obtained in a 7-rod bundle with spacers. It was a “blind” benchmark; the experimental data from a supercritical water test facility at Japan Atomic Energy Agency (JAEA) were revealed to participants during a meeting in June 25-26, 2014 at Delft. This paper deals with numerical results, obtained at Research Centre Rez during the “blind” phase of the benchmark and also results of some aftermath computations. Main goal was to test ability of the ANSYS FLUENT 12 code to simulate supercritical water flow and heat transfer in rod bundles using moderatesize computational grids. In order to limit the range of involved parameters, only one model of turbulence (SST k-ω) was selected; physical properties of supercritical water were calculated by REPROP 7 package. Mainly the results for Case B2 where water temperature crosses the pseudo critical temperature are presented here. Several computational grids with increasing size were produced with GAMBIT 2.4. 6 preprocessor, and skewness, aspect ratio and size change were selected as monitored characteristics of grid quality. Due to hardware limitations, only 1/12 of the bundle was modeled. In all blind calculations, heat transfer deterioration region appeared when case B2 was simulated. The main results (wall temperatures) obtained using all grids were compared with measured data. Aftermath simulations were focused on determination of effects of buoyancy and spacers on heat transfer phenomena.
Late Reduction of Cocaine Cravings in a Randomized, Double-Blind Trial of Aripiprazole vs Perphenazine in Schizophrenia and Comorbid Cocaine Dependence

Purpose Co-occurring schizophrenia spectrum disorder and International Statistical Classification of Diseases, 10th Revision cocaine dependence present a particularly destructive constellation that is often difficult to treat. Both conditions raise dopamine transmission effects in the brain. Traditional neuroleptics block dopamine receptors, whereas aripiprazole modulates dopamine activity as an agonist/antagonist. We tested whether dopamine modulation is superior to dopamine blocking in dual-diagnosis patients. Methods In a randomized, double-blind, comparison design, cocaine-dependent schizophrenic subjects actively using cocaine received either aripiprazole or perphenazine in an 8-week trial. Primary outcome targeted cocaine-free urine sample proportions, whereas cocaine craving scores were a secondary variable. Results Subjects (N = 44) randomized (n = 22 per group) did not differ at baseline. The proportion of cocaine-free urine samples did not differ by medication group. Contrasting weeks 3 to 5 vs 6 to 8 revealed significant late reductions in craving with aripiprazole. On the respective 5-point subscales, craving intensity decreased by 1.53 ± 0.43 (P < 0.0005) points, craving frequency by 1.4 ± 0.40 (P > 0.0004) points, and craving duration by 1.76 ± 0.44 (P > 0.0001) points. Conclusions A drug effect of aripiprazole on craving items appeared at week 6 of treatment, on average, and was not seen before that length of drug exposure. The data suggest that dopamine modulation reduces cocaine cravings but requires an acclimation period. To understand the mechanism of action better, a trial of depot aripiprazole may be useful. Clinically, a reduction in craving potentially offers a clearer focus for ongoing behavioral treatment. It may also offer a longer-term treatment effect with respect to the severity of relapse.
Helping Diminish the College Knowledge and Access Divide: Development of a College Outreach Camp to Serve Community Needs

This descriptive case study examined the development of a college outreach summer camp at a university in Texas. The camp aims to diminish the college knowledge and access divide that exists between first generation college-going, lower-income, and underrepresented students and their counterparts in the region in which the university is located. Drawing on one year of survey data, interviews with program personnel, program documents, and newspaper articles about the camp, this study highlights some of the camp’s early successes, as well as growing pains of starting such an effort to serve community needs.
Comparing Results from Telephone Reinterview with Unmoderated, Online Cognitive Interviewing

Results from an unreconciled telephone reinterview were compared with results from an unmoderated, online cognitive interview to test questions designed to measure specific vocational preparation (SVP). Debriefings from a field test had indicated that the questions used to measure SVP led to some respondent confusion and possible misreporting. Revised SVP questions were tested using a telephone reinterview and unmoderated, online cognitive testing. A reinterview with 30 employers was conducted without reconciliation by two experienced interviewers (one conducting the interview, and one observing), and focused on identifying comprehension problems. Business establishments were selected to provide a wide range of industries, geography, and size classes. The fully scripted online cognitive interview relied on 11 participants talking aloud to determine how well the questions worked. With one exception, both pretesting approaches identified the same problematic questions and issues, but the reinterview provided additional valuable information about a more effective reordering of the SVP questions.
Spoken word access processes: An introduction

We introduce the papers in this special issue by summarising the current major issues in spoken word recognition. We argue that a full understanding of the process of lexical access during speech comprehension will depend on resolving several key representational issues: what is the form of the representations used for lexical access; how is phonological information coded in the mental lexicon; and how is the morphological and semantic information about each word stored? We then discuss a number of distinct access processes: competition between lexical hypotheses; the computation of goodness-of-fit between the signal and stored lexical knowledge; segmentation of continuous speech; whether the lexicon influences prelexical processing through feedback; and the relationship of form-based processing to the processes responsible for deriving an interpretation of a complete utterance. We conclude that further progress may well be made by swapping ideas among the different sub-domains of the discipline.
On the Uniqueness of Code Redundancies

Code redundancy widely occurs in software projects. Researchers have investigated the existence, causes, and impacts of code redundancy, showing that it can be put to good use, for example in the context of code completion. When analyzing source code redundancy, previous studies considered software projects as sequences of tokens, neglecting the role of the syntactic structures enforced by programming languages. However, differences in the redundancy of such structures may jeopardize the performance of applications leveraging code redundancy. We present a study of the redundancy of several types of code constructs in a large-scale dataset of active Java projects mined from GitHub, unveiling that redundancy is not uniform and mainly resides in specific code constructs. We further investigate the implications of the locality of redundancy by analyzing the performance of language models when applied to code completion. Our study discloses the perils of exploiting code redundancy without taking into account its strong locality in specific code constructs.
Non-surgical Transfer of Porcine Embryos with two Types of Catheters

P55 Porcine Embryo Fragmentation and Apoptotic Markers: A Confocal Microscopy Study B Mateusen, A Van Soom, D Maes and A de Kruif Faculty of Veterinary Medicine, Ghent, Belgium The relationship between embryonic fragmentation and apoptosis has been the subject of some controversy. In order to investigate a possible link, in vivo produced, in vitro cultured porcine embryos (n 1⁄4 132) were scored for fragmentation at 7 days post-insemination and processed for annexin V and TUNEL labelling. The degree of fragmentation was assessed by differential interference contrast microscopy at 40· using two different scoring systems: (1) degrees of fragmentation (in percentage) and (2) patterns of fragmentation as described by Alikani et al. (2000). Subsequently, embryos were analyzed for apoptosis by annexin V and TUNEL assay using a confocal laser scanning microscope. A cell was categorized as apoptotic if: (i) the cell had nuclear morphological characteristics of apoptosis such as fragmentation or condensation; (ii) the cell membrane was annexin V positive and (iii) the nucleus of the cell was TUNEL labelled. Based on this definition an apoptotic cell ratio (ACR) was determined as the percentage of apoptotic cells per embryo. None of the embryos without fragmentation had cells categorized as apoptotic, whereas 49 out of 55 embryos with fragmentation possessed apoptotic cells. The degree and percentage of fragmentation were both linked with the apoptotic cell ratio (p < 0.001). The correlations detected between the degree of fragmentation and ACR, and the pattern of fragmentation and ACR, were 0.867 and 0.864, respectively. In conclusion, a significant relationship between porcine embryo fragmentation and apoptosis was shown in this study.
Antifungal Activity of Geraniol on Candida albicans Isolates of Pediatric Clinical Importance

Geraniol is a plant-derived monoterpene alcohol that has antifungal effect. The aim of this study was to evaluate the geraniol for antifungal activity against Candida albicans isolates of pediatric clinical importance. The minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were determined by the broth microdilution techniques. We also investigated possible geraniol action on cell walls (0.8M sorbitol) and cell membranes (Geraniol to ergosterol binding). For 90% of isolates, the MIC and MFC of the phytochemical was 64 μg/ml. Involvement with the cell wall and ergosterol binding were excluded as possible mechanisms of action. Thus, geraniol showed in vitro antifungal potential against strains of C. albicans, but did not involve action on the cell wall or ergosterol and further study is needed to completely describe its mechanism of action.
Farm Profits and Motivation Patterns in North-Central Namibia

The purpose of this master thesis is to survey small-scale crop farm profits in north-central Namibia and also to evaluate the associated motivation for farming. Knowledge of farmers profit and motivations as well as their inter linkages is important for potential intervention mechanisms aiming to improve the prevailing farming system. On a theoretical basis three motivation patterns were synthesized and brought into context with expected differences of net farm profits of these patterns. In 41 interviews quantitative data about farm profit and motivations was assessed in north-central Namibia. On average, the studied farms have positive net profits with high variations between the farms. Aiming the motivations, securing food and cultural motives were found to be the main drivers for farming. It is then shown that diverging farming behaviours can be explained by motivational differences. The behaviour of farmers is influencing the yields and thereby also the net farm profits. Findings presented in this thesis give empirical evidence that this motivation based mechanism can explain noticeable amount of the observed farm profit variations.
Spectral Analysis of Hand Tremors Induced During a Fatigue Test

In this paper, we analyze various kinds of hand tremors in the time and frequency domain, that are induced by performing a set of hand actions. We collected the tremor data using a simple, wearable accelerometer from 15 healthy individuals that had varying levels of athleticism. The overall results presented here show that the physiologic tremors in range of 8-14 Hz are most noticeable under fatigue.
SPEED WARNING SYSTEM USING SOLAR POWER

It is recorded that road vehicle accidents in Malaysia are increasing yearly. The major cause to road accident is mostly caused by human speed. Police authorities have enforced the speed limits of the vehicle to control the road accidents. Thus, to monitor the traffic more efficiently, the speed of a moving vehicle is determined by using calculation from particular distance and time as an approach to estimate the vehicle speed. This system is designed to reduce the road accidents in development of speed warning system by using solar power energy. Solar is used to provide the energy to the system in terms of optimizing the operational cost and reducing the energy wastage. It requires a battery to store energy that automatically recharged from solar panel. Three light indicators which are green, yellow and red based on the speed level of vehicles are used in this system. The indicators shows the condition of the speed warning system, whether in slow, fast and very fast conditions. With that, people will be motivated to follow the rules and enhance their responsibilities on the road. At the same time, this system is implemented to increase awareness on people regarding safety. The results are performed for the status of light indicator, the time taken and condition based on the speed detected by the system to show the effectiveness of the system.
The Effect of Flipped Classroom Strategy on Students Learning Outcomes

The purpose of this study is to examine the effects of the flipped classroom strategy to preparatory year instruction on student’s self-regulation and social connectedness. A quasi-experimental pre-post-test design conducted with 160 university students enrolled in three educational tracks (health, engineering and science). The students were divided into two groups: an experimental flipped classroom group and a control group. Experimental group was taught via flipped classroom, while the control group taught via traditional strategy. The levels of self-regulation and social connectedness were measured through questionnaire at the beginning and the end of the classes. The results based on ANOVA analysis reported that students in flipped classroom had shown significantly higher level of self-regulation and social connectedness compared to students in the traditional group. Based on the obtained findings, self-regulated learning and social connectedness were successful in making significant improvements among students exposed to flipped classroom mode compared to their counterparts in the traditional group. The results demonstrate that flipped classroom strategy can be used to promote self-regulated learning and enhancing students’ social connectedness.