Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of the lateral musculature in the teleost, Brachydanio rerio: a fine structural study.

The lateral musculature in the midbody region of the teleost, Brachydanio rerio, was examined by light and electron microscopy in the adult and six developmental stages. Two main divisions of the adult lateral musculature are described: (1) a superficial portion composed of small, dark fibers with high fat content and succinic dehydrogenase (SDH) activity; and (2) a deep portion composed principally of larger, pale, “deep fibers” showing little SDH activity and containing little fat. Some “intermediate fibers” are also present in the deep portion near the horizontal septum. Myofibrils of all cell types appear ultrastructurally similar. A general outline of myotomal differentiation has been established for the midbody somites. Myogenesis begins at the medial surface of the somite between the 20- and 25-somite stages and progresses laterally. Shortly before hatching, the myotome contains two structurally dissimilar types of young muscle cells. The appearance of these two muscle cell populations in larvae and fry supports the hypothesis that they develop into the superficial and deep portions of the adult lateral musculature. The intermediate fiber population is present by 2 1/2 months. The most lateral cells of the somite form a layer of flattened cells covering the lateral myotomal surface in the 33-somite embryo, and are considered to form the dermatome in this species.
Running Head: VALUES AS SELF-GUIDES Cultural Differences in Values as Self-Guides

Three studies tested whether individualism–collectivism moderates the extent to which values are endorsed as ideal self-guides and ought self-guides, and the consequences for regulatory focus and emotion. Across Studies 1 and 2, individualists endorsed values that are relatively central to the self as stronger ideals than oughts, whereas collectivists endorsed them as ideals and oughts to a similar degree. Study 2 found that individualists justified central values using reasons that were more promotion-focused than prevention-focused, whereas collectivists used similar amount of prevention-focused and promotion-focused reasons. In Study 3, individualists felt more dejected after violating a central (vs. peripheral) value and more agitated after violating a peripheral (vs. central) value. Collectivists felt a similar amount of dejection regardless of values centrality and more agitation after violating central (vs. peripheral) values. Overall, culture has important implications for how we regulate values that are central or peripheral to our self-concept.
Bioinformatic analyses of sense and antisense expression from terminal inverted repeat transposons in Drosophila somatic cells

ABSTRACT Understanding regulation of transposon movement in somatic cells is important as mobile elements can cause detrimental genomic rearrangements. Generally, transposons move via one of 2 mechanisms; retrotransposons utilize an RNA intermediate, therefore copying themselves and amplifying throughout the genome, while terminal inverted repeat transposons (TIR Tns) excise DNA sequences from the genome and integrate into a new location. Our recently published work indicates that retrotransposons in Drosophila tissue culture cells are actively transcribed in the antisense direction. Our data support a model in which convergent transcription of retrotransposons from intra element transcription start sites results in complementary RNAs that hybridize to form substrates for Dicer-2, the endogenous small interfering (esi)RNA generating enzyme. Here, we extend our previous analysis to TIR Tns. In contrast to retrotransposons, our data show that antisense TIR Tn RNAs result from transcription of intronic TIR Tns oriented antisense to their host genes. Also, disproportionately less esiRNAs are generated from TIR transcripts than from retrotransposons and transcription of very few individual TIR Tns could be confirmed. Collectively, these data support a model in which TIR Tns are regulated at the level of Transposase production while retrotransposons are regulated with esiRNA post-transcriptional mechanisms in Drosophila somatic cells.
Investigation of a population exposed to organomercurial seed dressings.

Urinary mercury and protein output rates, together with serum phosphoglucose isomerase activity, in 33 cereal seed dressers in East Scotland, employed seasonally, were compared with 33 age-matched controls. Increased mercury urinary concentrations, significant low-grade proteinuria, and inhibition of serum phosphoglucose isomerase were found. Blood mercury concentrations were significantly higher than normal controls. The enzymic activity of glutathione reductase in the sera of the seed dressers was within the normal range. There were no significant abnormalities in the electrocardiographic recordings in the seed dressers. The pathological and prognostic significance of these abnormalities is uncertain, but the results indicate the need for stricter protective measures.
Can caregivers be used in assessing oral health-related quality of life among patients hospitalized for acute medical conditions?

OBJECTIVES To assess the agreement between patients' and caregivers' (CGs) assessment of patients' oral health-related quality of life (OHRQoL) during the acute stage of their hospitalization. METHODS A sample of 161 consecutive patients admitted to hospital following stroke and their CGs. Patients and CGs were interviewed independently about the impact of oral health status on the life quality of the patient employing the General Oral Health Assessment Index (GOHAI). Agreement of impact was assessed by comparison (agreement at the group level) and correlation analyses (agreement of individual patient-CG pairs). RESULTS The response rate was 76% with 121 pairs of patients and CGs participating. At the group level, variations in patient's own and CG GOHAI scores were found (P < 0.001). The CGs underestimated the impact of oral health on life quality, particularly with respect to aspects of psychosocial functioning compared with patients' own perceptions. However, the bias in reports was small (standardized difference = 0.43). The mean absolute difference in overall scores constituted 8% of the possible range of GOHAI scores. At the individual patient-CG pair level, the intraclass correlation coefficient for GOHAI scores was 0.73 (95% CI 0.61-0.82), indicating substantial agreement. CONCLUSION At the group and individual level there was adequate agreement between patients' and CGs' assessment of patients' OHRQoL during the acute stage of their hospitalization. The findings have implications in the use of CGs as proxies in assessing oral health when patients' own assessment may be difficult to obtain.
Multidisciplinary Model for Smart Agriculture using Internet-of-Things ( IoT ) , Sensors , Cloud-Computing , Mobile-Computing & Big-Data Analysis

Although precision agriculture has been adopted in few countries; the agriculture industry in India still needs to be modernized with the involvement of technologies for better production, distribution and cost control. In this paper we proposed a multidisciplinary model for smart agriculture based on the key technologies: Internet-of-Things (IoT), Sensors, Cloud-Computing, Mobile-Computing, Big-Data analysis. Farmers, Agro-Marketing agencies and Agro-Vendors need to be registered to the AgroCloud module through MobileApp module. AgroCloud storage is used to store the details of farmers, periodic soil properties of farmlands, agro-vendors and agro-marketing agencies, Agro e-governance schemes and current environmental conditions. Soil and environment properties are sensed and periodically sent to AgroCloud through IoT (Beagle Black Bone). Bigdata analysis on AgroCloud data is done for fertilizer requirements, best crop sequences analysis, total production, and current stock and market requirements. Proposed model is beneficial for increase in agricultural production and for cost control of Agro-products.
Register-based machine translation evaluation with text classification techniques

This paper presents a novel approach to machine translation evaluation by combining register features – characterised by particular distributions of lexico-grammatical features – with text classiﬁcation techniques. The goal of this method is to compare machine translation output with comparable originals in the same language, as well as with human reference translations. The degree of similarity – in terms of register features – between machine translations and originals, and machine translations and reference translations is measured by applying two text classiﬁcation methods trained on 1) originals and 2) reference translations, and tested on machine translations. The results from the experiments prove our assumption that machine translations share register features rather with human translations than with non-translated texts produced by humans. This conﬁrms that registers are one of the most important factors that should be integrated into register-based machine translation evaluation.
Management Motives Behind the Revaluation of Fixed Assets for Sustainability of Entrepreneurial Companies

In the last decade several companies have revalue their assets. The companies revalue their assets by showing that they want to present a true and fair value of their assets as identified by the international reporting standards. As prescribed in the standards, the purpose of any accounting policy is to give true and fair value of the company to make it more sustainable. Because depiction of true and fair view of the company enhances confidence of the investors, which ultimately keep the company sustainable especially in the case of entrepreneurial ventures. In order to meet the objective of identification of management motives behind the revaluation of assets, primarily literature was reviewed which highlighted certain factors. In order to explore other hidden motives, exploratory study was conducted. The purpose of conducting qualitative research was to identify any other factor which has not yet been covered. For the said purpose data was collected from seven professions; including academicians, entrepreneurs, chartered accountants, and finance heads. The findings revealed that revaluation is done primarily for the improvement of financial position to satisfy the investors so that more funds may be generated. The study suggested a quantitative study on the identified constructs and also suggested the entrepreneurs, policy makers, and governments to revalue the assets appropriately to get maximum benefits of revaluation for the sustainability of the companies.
Linear models based on business data from the pharmaceutical industry

This article describes the analysis of heterogeneous market data. For this purpose, the most relevant methodological aspects are discussed and analyses using a hierarchical linear model and multiple regression are presented. In the first step, the applied data set is presented, and the assumed hierarchical two-level structure is shown. The data are then prepared for the analysis. The data are checked for outliers, a multicollinearity check is conducted, a new variable introduced, missing values are replaced by estimated values, a transformation procedure is conducted in order to obtain normality, the data are aggregated for each hierarchical level and a sample size test is performed. The results of both methods are discussed. Finally, it is concluded that whereas the application of a hierarchical linear model appears to be one option, a multiple regression analysis can be employed instead if the quality of the data, especially the sample size, is not sufficient.
CYCLOSPORINE AND THE ISCHEMIC RAT KIDNEY

The effects of cyclosporine (CsA) on renal function and morphology have been studied in the rat after unilateral nephrectomy and warm renal ischemia. There is evidence of an enhanced CsA nephrotoxic effect after unilateral nephrectomy alone and of an additive or synergistic effect of CsA and renal ischemia upon renal function and morphology. These enhanced effects are most evident after longer periods of ischemia (60 min) and with higher doses of CsA (25 mg/kg/day). The findings may be relevant to clinical practice and suggest that the nephrotoxic effects of CsA upon the door kidney may be greatest when there is coincident renal damage from other causes.
Lett Mood improving Potential of a Vitamin Trace Element Composition – A randomized , double blind , placebo controlled clinical study with healthy volunteers

OBJECTIVES: Neurotransmitters regulate mood, attention vigilance and other clinical symptoms linked with depression. Various medications ameliorate symptoms of depression and mood disorders by interference with the serotonic metabolism. Serotonin metabolism depends on nutritional cofactors such as pyridoxin together with essential mineral and trace elements. Both, inflammation and metabolic conditions seem to affect the bioavailability of serotonin crucially. We hypothesized that serotonin supply depends on relevant gastrointestinal precursor absorption and on the availability of nutritive antiinflammatory cofactors. METHODS: We performed a randomized placebo controlled clinical trial in healthy participants to study the bioavailabilty of ingredients of the multivitamin and trace element LaVita® in a prospective randomized placebo controlled double blind trial to establish the mood ameliorating potential. Serotonin and its precursor tryptophan were measured in dry blood samples. Serum parameters like chromium and zinc, as well as vitamin D, vitamin B3 and B6 were determined before intake, and after 3 months and 6 months consumption of the test substances. RESULTS: After 3 months a slight increase of tryptophan (p=0.059) and a significant increase of serum serotonin (p<0.013) was observed in the verum group. After 6 months the verum group showed a highly significant mean increase in niacin (p<0.001) and the cofactors of serotonin metabolism pyridoxin (p=0.03), chromium p<0.01), and zinc (p<0.001). Serotonin levels droped after 6 months indicating a low risk for overdosing. CONCLUSION: We conclude that a continuous supply with ingredients from the natural source compound LaVita® may contribute to mood improving neurotransmitter activity.
Liposome, gel and lipogelosome formulations containing sodium hyaluronate

Abstract The moisture-imparting effect of sodium hyaluronate (Na-HA) was investigated in liposome, gel and lipogelosome topical formulations. Sixteen liposome formulations were prepared with or without Na-HA (45 kDa) using various ratios of dimyristoylphosphatidylcholine, 1,2-dimyristoyl-sn-glycero-3-phosphatidylglycerol, dipalmitoylphosphatidylcholine and phospholipon 100H. The liposomes were characterized in terms of their structure, composition, zeta potential, Na-HA-entrapment capacity and stability. In particular, scanning electron microscopy, polarized light microscopy, dynamic light scattering and atomic force microscopy were utilized to probe appearance, size and size distribution and lamellarity. The work was then extended to gels using the gelling agents poloxamer (PXM 188 or 407) and Carbopol or Ultrez 21 (U-21), yielding liposome-loaded gel formulations (i.e. lipogelosomes). The in vitro release kinetics of Na-HA from liposomes, lipogelosomes and commercial Na-HA reference formulations were studied via a flow-through cell method. Among the liposomal formulations tested, L6, comprising of Na-HA-loaded phospholipon 100H:stearylamine:cholesterol (7:1:2), displayed optimal traits. The mean particle size, zeta potential and entrapment capacity of L6 were determined as 1900 nm, −20.9 mV and 15.0%. The optimum lipogelosome, LG4, was obtained by incorporating liposome L6 into a U-21 gel at a ratio of 1:1 (w/w). In clinical trials, in-house formulations were applied twice daily to 15 female volunteers. The two-week benefits were assessed against a commercial product; and in all cases, changes of skin humidity, sebum content, pH and wrinkle depth were promising. In particular, the LG4 lipogelosome-based formulation had significantly improved skin hydration and compliance, as evidenced by a moisture content gain of 30.4%.
The online consumer behavior outside Java Island: A case study of Lazada Indonesia

Indonesia has become a grow developing country with more than 260 million of people in size and 132 million Internet subscribers are interconnected. The Internet penetration and the number of online shoppers in Indonesia continues to grow significantly. This study aimed to analyze online consumer behavior outside Java Island based-on Lazada Indonesia’ case, in-order to provide solutions to reach new target markets in each province. The study was using online survey method and descriptive statistics analysis which used Lazada Indonesia’s customers and non-customer as the target respondents. Some variables such as online shopping motivation, media accessed, product category preferences and other variables associated with online shopping were included in the research. The results indicated a significant growth in mobile device purchases by online shopping and high demand in fashion product categories. Digital marketing efforts would also become important tools in online marketing activities.
Post‐translational modifications of ICA512, a receptor tyrosine phosphatase‐like protein of secretory granules

The autoantigen of type I diabetes ICA512 is a receptor tyrosine phosphatase‐like protein enriched in the secretory granule membranes of neurons and peptide secreting endocrine cells. While the function of ICA512 remains unknown, it is thought to link regulated neuropeptide and peptide hormone secretion with signal transduction pathways involving tyrosine phosphorylation/dephosphorylation. To characterize further its biochemical properties, we conducted studies in the bovine pituitary, an abundant source of native ICA512, as well as in fibroblasts transfected with various human ICA512 cDNA constructs. Based on these studies we have established that the signal peptide of ICA512 encompasses residues 1–34 and that the ectodomain of ICA512 undergoes multiple post‐translation modifications, including N‐glycosylation. Newly synthesized ICA512 appears first as a pro‐protein of 110 kDa that is then converted by post‐translational modifications into a 130‐kDa species. Cleavage of pro‐ICA512 at a consensus for furin‐like convertases generates a 60–66‐kDa ICA512 transmembrane fragment (amino acids 449–979). Such processing ICA512 is not restricted to neuroendocrine cells, as it can also occur in transfected fibroblasts. Finally, the predicted N‐terminal fragment of ICA512 resulting from this cleavage (amino acids 35–448) or parts thereof are present in the neurosecretosomes of posterior pituitary, raising the possibility that they may be secreted upon exocytosis of secretory granules.
Attachment in young children with autism spectrum disorders: An examination of separation and reunion behaviors with both mothers and fathers

Most studies examining attachment in children with autism spectrum disorder used a strange situation paradigm and have found few significant group differences between children with autism spectrum disorder and comparisons. However, these studies predominantly used formal attachment categorizations (e.g. secure vs insecure), a method that may obscure more nuanced differences between groups. In this study, we utilized a qualitative approach to examine attachment behaviors in young children with autism spectrum disorder. Based on the results of previous studies, we looked at (a) parental gender, (b) child diagnosis, and (c) child cognitive skills to examine the role of these three factors on attachment behaviors elicited during a modified strange situation paradigm. Participants were 2- to 3-year-old children with autism spectrum disorder (n = 166) or nonspectrum disorders (n = 45), as well as a sample of 56 children with typical development. Over the three groups, 393 observations of a modified strange situation paradigm with mothers and 127 observations with fathers were collected. Parental gender, child diagnosis, and child cognitive skills each had significant main effects on attachment behaviors elicited during reunion. These results underscore the importance of the father’s role in parent–child interactions, with implications for both clinical and research efforts. In addition, the results emphasize the importance of considering a child’s diagnosis and cognitive skills when examining attachment behaviors.
L2 perception of English vowels: testing the validity of Kuhl's prototypes

The present study investigates confusion patterns in the identification of English vowel sounds by native Spanish learners. The aim was to test the validity of Kuhl's Native Language Magnet (NLM) theory for Spanish learners with an intermediate level of competence in English. Following this theory, the English and Spanish vowel systems were compared in order to obtain a set of L2 confusion predictions that could be derived from the NLM model. It was hypothesized that the prototype model would fail to account for all the confusion patterns in our data since our subjects interlanguage phonological system was no longer a direct reflection of their Ll system. A test was conducted in which subjects were asked to identify RP vowels in monosyllabic words after receiving specific phonetic training. It was observed that few perceptual confusions could be explained according to the NLM model as interpreted for L2 acquisition. We propose that the NLM theory can only account for L2 data if revisions are made as to the nature of prototypes in the interlanguage. The NLM model should also take into account other factors that may shape prototypes such as vowel duration and universals principles.
Low-speed sensorless control of induction Machine

Induction motor (IM) speed sensorless control, allowing operation at low and zero speed, optimizing torque response and efficiency, will be presented in this paper. The magnitude and the orientation angle of the rotor flux of the IM are determined by the output of the closed-loop rotor-flux observer based on the calculation of the extended electromotive force of the machine. The proposed rotor-flux-oriented control scheme is robust to parameter variations and external disturbances. Both observer and controller utilize the continuous sliding mode and Lyapunov theory. A smooth transition into the field-weakening region and the full utilization of the inverter current and voltage capability are thus possible. The produced torque is a continuous output variable of control. The performance of the proposed method is investigated and verified experimentally on a digital signal processor.