Miracle-dz/UniFAR-FTUs huggingface dataset:
Vectorial Ca2+ flux from the extracellular space to the endoplasmic reticulum via a restricted cytoplasmic compartment regulates inositol 1,4,5-trisphosphate-stimulated Ca2+ release from internal stores in vascular endothelial cells.

Depletion of the Ins(1,4,5)P3-sensitive intracellular Ca2+ store of vascular endothelial cells after selective inhibition of the endoplasmic-reticulum (ER) Ca2+ pump by thapsigargin or 2,5-di-t-butylhydroquinone (BHQ) increases Ca2+ influx from the extracellular space in the absence of phosphoinositide hydrolysis. One model to account for these results suggests a close association between the internal store and the plasmalemma, allowing for the vectorial movement of Ca2+ from the extracellular space to the ER. Furthermore, recent evidence suggests that Ins(1,4,5)P3-induced Ca2+ release from intracellular stores is regulated by the free cytosolic Ca2+ concentration ([Ca2+]i). Thus agonist-induced Ca2+ entry may directly regulate Ca2+ release from internal stores. To test these hypotheses, we examined the effect of 1-(beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl)-1H-imidazole (SKF 96365), an inhibitor of Ca2+ influx, on unidirectional 45Ca2+ efflux (i.e. retrograde radioisotope flux via the influx pathway) and on [Ca2+]i as measured by fura-2. Bradykinin produced a transient increase in [Ca2+]i, reflecting release of Ca2+ from internal stores, and a sustained increase indicative of Ca2+ influx. In the absence of agonist, 45Ca2+ efflux was slow and monoexponential with time. Addition of BK dramatically increased 45Ca2+ efflux; 50-60% of the 45Ca2+ associated with the cell monolayer was released within 2 min after addition of bradykinin. Both the bradykinin-induced change in [Ca2+]i and the stimulation of 45Ca2+ efflux was completely blocked by loading the cells with the Ca2+ chelator BAPTA. At a supermaximal concentration of bradykinin (50 nM), SKF 96365 (50 microM) inhibited the rise in [Ca2+]i attributed to influx without affecting release from internal stores. At a threshold concentration of bradykinin (2 nM), SKF 96365 blocked influx, but stimulated Ca2+ release from internal stores, as indicated by increases in both the transient component of the fura-2 response and 45Ca2+ efflux. Thapsigargin (200 nM) and BHQ (10 microM) produced an increase in 45Ca2+ efflux that was completely blocked by SKF 96365 or by cytosolic loading with BAPTA. These results suggest the existence of a restricted sub-plasmalemmal space that is defined by an area of surface membrane which contains the Ca(2+)-influx pathway but is devoid of Ca2+ pumps, and by a section of ER that is rich in thapsigargin-sensitive Ca(2+)-pump units. (ABSTRACT TRUNCATED AT 400 WORDS)
Building a Business Knowledge Base by a Supervised Learning and Rule-Based Method

Natural Language Question Answering (NLQA) and Prescriptive Analytics (PA) have been identified as innovative, emerging technologies in 2015 by the Gartner group. These technologies require knowledge bases that consist of data that has been extracted from unstructured texts. Every business requires a knowledge base for business analytics as it can enhance companies’ competitiveness in their industry. Most intelligent or analytic services depend a lot upon on knowledge bases. However, building a qualified knowledge base is very time consuming and requires a considerable amount of effort, especially if it is to be manually created. Another problem that occurs when creating a knowledge base is that it will be outdated by the time it is completed and will require constant updating even when it is ready in use. For these reason, it is more advisable to create a computerized knowledge base. This research focuses on building a computerized knowledge base for business using a supervised learning and rule-based method. The method proposed in this paper is based on information extraction, but it has been specialized and modified to extract information related only to a business. The business knowledge base created by our system can also be used for advanced functions such as presenting the hierarchy of technologies and products, and the relations between technologies and products. Using our method, these relations can be expanded and customized according to business requirements.
Cloning of a locus involved in Streptococcus mutans intracellular polysaccharide accumulation and virulence testing of an intracellular polysaccharide-deficient mutant

The streptococcal transposon Tn916 (Tcr) was used to isolate mutants of Streptococcus mutans altered in glycogen accumulation to investigate whether glycogenlike intracellular polysaccharides (IPS) play an important role in S. mutans-induced caries formation. S. mutans UA130 (serotype c) was transformed with the Escherichia coli plasmid pAM620 (Tn916), and the resultant transposon libraries were screened for glycogen content by iodine staining. A transposon mutant, designated SMS201, demonstrated a glycogen-deficient phenotype on glucose-enriched medium. Quantitative electron microscopy confirmed that IPS concentrations were significantly reduced in SMS201 relative to the wild-type progenitor strain, UA130. Importantly, reversion to wild type correlated at all times with loss of the transposon. Transposon excisants were used to facilitate cloning of the streptococcal gene(s) involved in glycogen biosynthesis and storage. A 2.1-kb chromosomal determinant (glgR) which encodes a putative regulator of S. mutans glycogen accumulation was isolated. A stable deletion mutation (delta glgR) was subsequently generated in E. coli and introduced into S. mutans by allelic exchange. The resultant glycogen synthesis-deficient mutant, SMS203, demonstrated a significantly reduced cariogenic potential (P less than 0.01) on the buccal, sulcal, and proximal surfaces of teeth in germfree rats, relative to animals challenged with the glycogen synthesis-proficient progenitor strain, UA130. These observations confirm previous reports (J. M. Tanzer, M. L. Freedman, F. N. Woodiel, R. L. Eifert, and L. A. Rinehimer, p. 597-616, in H. M. Stiles, W. J. Loesche, and T. L. O'Brien, ed., Proceedings in Microbiology. Aspects of Dental Caries. Special Supplement to Microbiology Abstracts, vol. 3, 1976) which implicate IPS as significant contributors to the S. mutans cariogenic process.
Genetic algorithm-based optimized association rule mining for multi-relational data

The multi relational data mining is one of the latest topics in data mining to find the relational patterns. In this paper, we have presented an algorithm for multi-relational rule mining using association rule mining and the optimization process. As a result of the association rule mining on the multirelational data, a number of relevant and irrelevant rules are generated. A rule is specified as a relation between two data points in the dataset. So, an optimization should be done on the mining algorithm in order to get the most relevant rules. We have adapted the technique of genetic algorithm in order to optimize the mined multi relational association rules. The genetic algorithm is one of the best optimization algorithm available and it suites the current problem because of its particular features such as the genetic operators crossover and mutation. The optimization of the rule is done by altering the fitness function of the genetic algorithm in relation with the multi relational data mining algorithm. The results from the experimental analysis showed that the proposed approach has better efficiency over the previous approaches. The most rules optimized is 198 under iterations 10 with a support of 60.
Differential and Simultaneous Adenosine Di- and Triphosphate Binding by MutS*

The roles of ATP binding and hydrolysis in the function of MutS in mismatch repair are poorly understood. As one means of addressing this question, we have determined the affinities and number of adenosine di- and triphosphate binding sites within MutS. Nitrocellulose filter binding assay and equilibrium fluorescence anisotropy measurements have demonstrated that MutS has one high affinity binding site for ADP and one high affinity site for nonhydrolyzable ATP analogues per dimer equivalent. Low concentrations of 5′-adenylylimidodiphosphate (AMPPNP) promote ADP binding and a large excess of AMPPNP is required to displace ADP from the protein. Fluorescence energy transfer and filter binding assays indicate that ADP and nonhydrolyzable ATP analogues can bind simultaneously to adjacent subunits within the MutS oligomer with affinities in the low micromolar range. These findings suggest that the protein exists primarily as the ATP·MutS·ADP ternary complex in solution and that this may be the form of the protein that is involved in DNA encountersin vivo.
Joint effects of Gender Composition, Anonymity in Communication and Task Type on Collaborative Learning

Earlier research has suggested that anonymous communication is appropriate for creative task, and identified communication is suitable for decision-making task. The current study brings into this picture a third dimension – gender composition. Specifically, the work seeks for a better understanding on how the three components will intertwine in a collaborative learning context. The novel elements of gender and learning are in and of themselves significant. Through theoretical analyses, the paper arrives at a set of fruitful propositions. A central proposition conjectures that all-male learning groups will achieve the best learning outcome wile performing decision-making tasks using an identified style of communication; as well, all-female learning groups are expected to achieve the best learning outcomes while performing creative tasks via anonymous communication.
MIGRATORY BEHAVIOR OF BIRDS AFFECTS THEIR COEVOLUTIONARY RELATIONSHIP WITH BLOOD PARASITES

Host traits, such as migratory behavior, could facilitate the dispersal of disease‐causing parasites, potentially leading to the transfer of infections both across geographic areas and between host species. There is, however, little quantitative information on whether variation in such host attributes does indeed affect the evolutionary outcome of host–parasite associations. Here, we employ Leucocytozoon blood parasites of birds, a group of parasites closely related to avian malaria, to study host–parasite coevolution in relation to host behavior using a phylogenetic comparative approach. We reconstruct the molecular phylogenies of both the hosts and parasites and use cophylogenetic tools to assess whether each host–parasite association contributes significantly to the overall congruence between the two phylogenies. We find evidence for a significant fit between host and parasite phylogenies in this system, but show that this is due only to associations between nonmigrant parasites and their hosts. We also show that migrant bird species harbor a greater genetic diversity of parasites compared with nonmigrant species. Taken together, these results suggest that the migratory habits of birds could influence their coevolutionary relationship with their parasites, and that consideration of host traits is important in predicting the outcome of coevolutionary interactions.
Genetic diversity in Enterocytozoon bieneusi from dogs and cats in China : 1 host specificity and public health implications 2

24 To explore the genetic diversity, host specificity and zoonotic potential of Enterocytozoon 25 bieneusi, feces from 348 stray and pet dogs, and 96 pet cats from different locations in China 26 were examined by internal transcribed spacer (ITS) based PCR. E. bieneusi was detected in 27 15.5% of dogs including 20.5% of stray dogs and 11.7% of pet dogs, and in 11.5% of pet 28 cats. Higher infection rates were recorded in the > 2 years and 1 to 2 years age groups in 29 dogs and cats, respectively. All together, 24 genotypes, including 11 known and 13 new ones, 30 were detected in 65 infected animals. In 54 positive dogs, 18 genotypes, nine known 31 (PtEbIX, O, D, CM1, EbpA, Peru8, Type IV, EbpC and PigEBITS5) and nine new (CD1 to 32 CD9), were found. In contrast, eight genotypes, four known (D, BEB6, I and PtEbIX) and 33 four new (CC1 to CC4), were identified in 11 infected cats. The dominant genotype in dogs 34 was PtEbIX (26/54). Phylogenetic analysis revealed that eight known genotypes (D, Peru8, 35 Type IV, CM1, EbpC, PigEBITS5, O and EbpA) and seven new ones (CD1 to CD4 and CC2 36 to CC4) were the members of zoonotic group 1, whereas genotypes CD7, CD8 and CD9 37 together with PtEbIX belonged to the dog specific group, and genotypes CD6 and CC1 were 38 placed in group 2 with BEB6 and I. Conversely, genotype CD5 clustered with CM4 without 39 belonging to any previous groups. This study concludes that zoonotic genotypes are common 40 in both animals along with host specific genotypes in dogs. 41 42
Visualisation tool for teaching programming in C

This paper presents a visualisation tool for novice C programmers. It is well known that programming is perceived to be difficult among novice learners. The aim of this tool is to graphically visualise the code that the student is working on to give them a coherent computational model. It is hoped that this tool will help the learner achieve a coherent mental model in common with the instructor and the rest of the class. This could allow valuable class time to be concentrated on problem solving issues earlier in the teaching semester.
Multiobjective Battery Storage to Improve PV Integration in Residential Distribution Grids

This paper investigates the potential of using battery energy storage systems in the public low-voltage distribution grid, to defer upgrades needed to increase the penetration of photovoltaics (PV). A multiobjective optimization method is proposed to visualize the trade-offs between three objective functions: voltage regulation, peak power reduction, and annual cost. The method is applied to a near-future scenario, based on a real residential feeder. The results provide insight into the dimensioning and the required specifications of the battery and the inverter. It is found that an inverter without batteries already achieves part of the objectives. Therefore, the added value of batteries to an inverter is discussed. Furthermore, a comparison between lithium-ion and lead-acid battery technologies is presented.
Cerebrospinal fluid biomarkers of white matter lesions – cross‐sectional results from the LADIS study

Background and purpose: White matter lesions (WMLs) caused by small vessel disease are common in elderly people and contribute to cognitive impairment. There are no established biochemical markers for WMLs. We aimed to study the relation between degree of WMLs rated on magnetic resonance imaging of the brain and cerebrospinal fluid (CSF) levels of structural biomarkers associated with Alzheimer’s disease (AD) and subcortical vascular dementia.
Magnetic field rotating-type Faraday polarization controller

We developed a new polarization controller based on the Faraday effect. The transmittance fluctuation was suppressed to less than 0.03 dB by controlling the direction of a magnetic field with a magnitude exceeding the saturation field of Faraday elements. Because it has no mechanical parts, the new polarization controller can perform polarization control with high reproducibility and high-speed polarization control of better than 10/sup 3/ turns/s on a Poincare sphere. The new polarization controller has a rotatory polarization angle setting accuracy of /spl plusmn/5/spl deg/ and a reproducibility of /spl plusmn/0.3/spl deg/ on the Poincare sphere.
Sex differences in mediating and moderating processes linking economic stressors, psychological distress, and drinking.

OBJECTIVE Given the recent downturn in the U.S. economy, we considered in this study the processes linking economic stressors, psychological distress, and two alcohol-related outcomes (past-month drinking and problematic drinking). METHOD Data were drawn from a mail survey of a national sample of 663 respondents. Structural equation modeling was used to assess whether psychological distress mediates the associations between economic stressors and the alcohol-related outcomes considered and whether these associations varied by gender. RESULTS Controlling for correlations among the outcomes and the effects of the sociodemographic control variables, psychological distress was found to partly explain the association between economic stressors and problematic drinking. The mediating effects on problematic drinking were significantly greater for men than women. CONCLUSIONS The findings demonstrate the utility of considering interrelationships among alcohol-related outcomes and, in this context, reveal the circumstances in which gender matters most for understanding the associations among economy-related stressors, psychological distress, and drinking.
Las pruebas psicométricas en la investigación empírica sobre los procesos cognitivos del traductor

El creciente interes academico por la traductologia cognitiva ha venido acompanado de un incremento de los disenos de investigacion empirica sobre los procesos mentales del traductor (Fernandez Sanchez y Munoz Martin 2008). Entre otros aspectos metodologicos, en este tipo de experimentos es necesario atender a las diferencias de caracter psicologico de los sujetos de la muestra. Segun sea el diseno de investigacion, dichas diferencias individuales pueden actuar como variables independientes organismicas, manipuladas por el investigador para determinar su efecto, o como variables extranas, no relacionadas directamente con el proposito del estudio. En ambos casos es necesaria su cuantificacion. En este trabajo se describen los diferentes tipos de instrumentos de evaluacion psicologica al alcance del investigador. A continuacion, se presentan los tests mas utilizados para medir diferentes constructos psicologicos que pueden ser de interes para la traductologia. Por ultimo, tras revisar los factores que se deben tener en cuenta a la hora de elegir la prueba psicometrica mas adecuada, se exponen algunas recomendaciones para la administracion de los tests estandarizados, en consonancia con las normas profesionales del principal organismo regulador internacional de este campo.
The Implications of the Linguistic Turn on IS

The linguistic turn is one of the major shifts in philosophy and epistemology of the 20 th century. All fields in the social sciences have been influenced by this trend. The goal of this paper is to suggest the implications of the linguistic turn for IS research. We use a Kantian epistemological framework in order to identify these impacts on the four aspects of research. First, the linguistic turn leads to a research issue more focused on language through interpretivism and social-critical theory. Second, it suggests an objectivation process based more on understanding than on explanation. Third, the type of knowledge tends to be influenced more by an “a posteriori ” and descriptive knowledge, rather than an “a priori ” and normative one. Fourth, the conditions of possibilities tend to move from causality to a search for meaning (and particular/singular judgments). Implications for research practice are further developed in the discussion.
A study on improved efficiency and cooling LED lighting using a seebeck effect

Most problems of LED lighting systems are based on thermal problem so many researchers study this problem and develop higher performance cooling methods for LED lighting system. In this paper, we show that seebeck elements can be used for cooling system of LED lighting system. The cooling abilities of each system were studied to compare each LED cooling system. Each cooling systems consist of the only heat sink, seebeck element +heat sink, peltier element + heat sink. We used a 3W LED chip as light source and the LED chip were attached on a heat sink. The driving voltage of LED lighting is 10 V. In addition, either seebeck elements or peltier elements were attached between heat sink and LED substrate. The temperature of each cooling systems were measured by thermocouple and data was recorded by Data logger. As a result, cooling efficiency of LED with seebeck element is 9% higher than heat sink and 4% lower than peltier element. Therefore, peltier element is better than seebeck element on the performance of LED cooling, but peltier element was spent 0.4 W of power. Seebeck element is 9% less than peltier element on the performance efficiency of the cooling LED system. However 0.0035mW electric power was generated by seebeck element.
Electromyographic Analysis of Responses to Third Person Intergroup Threat

ABSTRACT This study attempts to replicate and extend the findings from Davis and Stephan’s (2011) article investigating facial electromyographic (EMG) responses to individually directed or group-directed realistic threat. Using news footage from the Columbine school shootings as a third-person threatening stimulus, participants were instructed to view the clips while considering how they felt during the original events (individually primed) or how students felt during the original events (group-primed). EMG analysis of activity levels of the medial frontalis and the corrugator supercilii indicated differential activation based on the instructions. Individually primed participants experienced more fontalis activity and group-primed participants experienced more corrugator supercilii activity. These findings replicated the Davis and Stephan results and extended it to a third person-based intergroup threat.
Application of Weighted Structured Total Least Squares in Identification of Power System Oscillation Modes

In this paper we present a novel method for estimating electromechanical modal parameters from noisy signals recorded during power system disturbances. The method is based on the weighted Structured Total Least Squares (STLS) approach for parametric signal modelling. Compared to Prony's method, the weighted version of STLS method is less sensitive to noise and trend components in recorded signal samples. It is shown through practical examples that the method displays high resolution in parameter estimation for some difficult cases with close modal frequencies, using only short signals recorded by Digital Fault Recorder.
Snow distribution patterns on Svalbard glaciers derived from radio-echo soundings

: The spatial distribution of snow thickness on glaciers is driven by a set of clima− tological, meteorological, topographical and orographic conditions. This work presents re− sults of snow accumulation studies carried out from 2006 to 2009 on glaciers of different types: valley glacier, ice plateau and ice cap. In order to determine snow depth, a shallow ra− dio echo−sounding method was used. Based on the results, the following snow distribution patterns on Svalbard glaciers have been distinguished: precipitation pattern, precipita− tion−redistribution pattern, redistribution pattern and complex pattern. The precipitation pattern assumes that the snow distribution on glaciers follows the altitudinal gradient. If the accumulation gradient is significantly modified by local factors like wind erosion and redeposition, or local variability of precipitation, the accumulation pattern turns into the precipitation−redistribution pattern. In the redistribution pattern, local factors play a crucial role in the spatial variability of snow depth. The complex pattern, however, demonstrates the co−existence of different snow distribution patterns on a single glacial object (glacier/ice cap/ice field).