Miracle-dz/UniFAR-FTUs huggingface dataset:
Accelerated Time-Resolved Contrast-Enhanced Magnetic Resonance Angiography of Dural Arteriovenous Fistulas Using Highly Constrained Reconstruction of Sparse Cerebrovascular Data Sets

ObjectiveTime-resolved contrast-enhanced magnetic resonance angiography (MRA) is commonly used to noninvasively characterize vascular malformations. However, the spatial and temporal resolution of current methods often compromises the clinical value of the examinations. Constrained reconstruction is a temporal spatial correlation strategy that exploits the relative sparsity of vessels in space to dramatically reduce the amount of data required to generate fast high-resolution time-resolved contrast-enhanced MRA studies. In this report, we use a novel temporal spatial acceleration method termed HYPRFlow to diagnose and classify dural arteriovenous fistulas (DAVFs). Our hypothesis is that HYPRFlow images are of adequate diagnostic image quality to delineate the arterial and venous components of DAVFs and allow correct classification using the Cognard system. Subjects and MethodsEight patients with known DAVFs underwent HYPRFlow imaging with isotropic resolution of 0.68 mm and temporal resolution of 0.75 second and 3-dimensional time-of-flight (3DTOF) MRA. The 3DTOF images and HYPRFlow images were evaluated by 2 readers and scored for arterial anatomic image quality. Digital subtraction angiography (DSA) was available for comparison in 7 subjects, and for these patients, each DAVF was classified according to the Cognard system using HYPRFlow and DSA examinations. Digital subtraction angiography was considered the reference examination or criterion standard. ResultsHYPRFlow imaging classification was concordant with DSA in all but 1 case. There was no difference in the arterial image quality scores between HYPRFlow and 3DTOF MRA (95% confidence interval). Arterial-to-venous separation was rated excellent (n = 3), good (n = 4), or poor (n = 1), and arteriovenous shunting was easily appreciated. Undersampling artifacts were reduced by using a low pass filter and did not interfere with the diagnostic quality of the examinations. ConclusionsHYPRFlow is a novel acquisition and reconstruction technique that exploits the relative sparsity of intracranial vessels in space to increase temporal and spatial resolution and provides accurate delineation of DAVF vasculature.
Feature selection for SNP data based on Relief-SVM

The presence of Single nucleotide polymorphism causes DNA sequence difference, affects protein changing the structure and function, which causes the human genetic disease. The whole genome wide association is a new strategy to screen SNP with disease related, it avoids the hypothesis before non-fully evidence, but it increases the difficulties of screening SNP with disease. Now in the whole genome wide association the association analysis of single SNPs has been considered and without the consideration of the interaction among SNPs, thus the SNP of screening are not entirely credible. In order to improve the classification accuracy of SNP selecting, this paper proposed a feature selection method based on Relief-SVM for SNP data, which can screen important SNP with disease related
Structural dynamics flexibility informs function and evolution at a proteome scale

Protein structures are dynamic entities with a myriad of atomic fluctuations, side‐chain rotations, and collective domain movements. Although the importance of these dynamics to proper functioning of proteins is emerging in the studies of many protein families, there is a lack of broad evidence for the critical role of protein dynamics in shaping the biological functions of a substantial fraction of residues for a large number of proteins in the human proteome. Here, we propose a novel dynamic flexibility index (dfi) to quantify the dynamic properties of individual residues in any protein and use it to assess the importance of protein dynamics in 100 human proteins. Our analyses involving functionally critical positions, disease‐associated and putatively neutral population variations, and the rate of interspecific substitutions per residue produce concordant patterns at a proteome scale. They establish that the preservation of dynamic properties of residues in a protein structure is critical for maintaining the protein/biological function. Therefore, structural dynamics needs to become a major component of the analysis of protein function and evolution. Such analyses will be facilitated by the dfi, which will also enable the integrative use of structural dynamics with evolutionary conservation in genomic medicine as well as functional genomics investigations.
The right of children to be heard in civil proceedings and the emerging law of the European Court of Human Rights

The right of children to be heard in civil proceedings affecting them as enshrined by the Convention on the Rights of the Child is not expressly contained within the European Convention of Human Rights, nor has such a right been explicitly determined by the European Court of Human Rights. However considering the principles of evolutive interpretation, the positive obligations inherent within art. 6 and art. 8 as well as the case law on hearing children to date, it is to be argued that such a right can be derived under the Convention.
The phyllochron of well-watered and water deficit mature peach trees varies with shoot type and vigour

The addition of new nodes to shoots is an essential mechanism for understanding and modelling canopy growth but surprisingly, there is very little research on the factors that control the phyllochron in tree species. It is often assumed that the phyllochron is regulated by temperature and is consistent among all shoot types. This research clearly indicates that this is not the case. This study shows differences in the phyllochron between different shoot types and water treatments that appear to be associated with rank effect rather than temperature.
Role of CREB in modulation of TNF and IL-10 expression in LPS-stimulated RAW 264 . 7 macrophages

The role of CREB in LPS signaling is controversial. The objective of this study was to evaluate the effect of LPS on phosphorylation and transcriptional activation of CREB, in comparison to isoproterenol, a adrenergic receptor agonist. We show here that LPS elevates intra-cellular cAMP level in RAW264.7 macrophages, with slower kinetics and lower magnitude than isoproterenol. The two agents stimulated CREB phosphorylation on Ser-133 to a similar extent, but with a different mechanism; rapid and mostly PKA-mediated for isoproterenol; slow and MSK1-mediated for LPS. Interestingly, LPS-stimulated phosphorylation of CREB did not result in transcriptional activation of a CRE-regulated luciferase reporter, in contrast to stimulation by isoproterenol. Furthermore, inhibitors of p38 and MSK1, but not PKA, completely blocked the production of IL-10 and TNF in LPS-stimulated macrophages. Distinctively, the PKA inhibitor H89 blocked the suppressive effect of isoproterenol on TNF production, as well as its stimulatory effect on IL-10 induction, in LPS-stimulated macrophages. Likewise, while over-expression of dominant negative CREB had no effect on LPS-stimulated TNF production, it blocked the suppressive effect of isoproterenol on TNF production in the LPS-stimulated macrophages. Our results thus indicate that PKA-mediated phosphorylation of CREB promotes TNF suppression and IL-10 induction, whereas the same phosphorylation event initiated by LPS and mediated by MSK1 is non-functional for transcriptional modulation. © 2010 Elsevier Ltd. All rights reserved.
Implications of gestalt theory and practice for the learning organisation

Concepts about the learning organisation have become popular ideas for companies and organisations alike to promote the learning process within them. The practice has, however, received a mixed reception somewhere between enthusiasm and scepticism. This is because the ideas themselves have been developed from different interpretations of the concept. There is, however, strong commitment from various individuals in organisations who make an attempt to explore and use the concepts of the learning organisation. This paper introduces and explores the concept and practice of gestalt therapy. The article explores the similarity between the concepts and practice of the learning organisation, and gestalt therapy, such as concepts of learning, holism, existential phenomenology, mental models, and team learning, with examples from his practice. The author concludes with his integrative model and believes that this contribution may further improve the understanding of the concepts of the learning organisation.
Non-Data-Aided Code Synchronization for the Code-Shifted Reference Ultra-Wideband (UWB) System

This paper investigates code synchronization for a recently proposed code-shifted reference (CSR) impulse radio ultra-wideband (IR-UWB) system. In the CSR scheme every symbol with the code-shifted information bits is conveyed by several frames and during each frame only one pulse is transmitted. By assuming that the start of each frame concerning the receiver's clock is known,two code synchronization algorithms are proposed to estimate the position of the first frame in each symbol and each algorithm works without using a preamble sequence.The performance of the two algorithms are evaluated under IEEE802.15. 4a industrial line-of-sight (LOS)scenario. The simulation results reveal that the second algorithm with the partial Euclidean distance minimization outperforms the first algorithm with the direct searching.
Technical Debt: From Metaphor to Theory and Practice

The metaphor of technical debt in software development was introduced two decades ago to explain to nontechnical stakeholders the need for what we call now "refactoring. " As the term is being used to describe a wide range of phenomena, this paper proposes an organization of the technical debt landscape, and introduces the papers on technical debt contained in the issue.
Ultrafast sub-threshold photo-induced response in crystalline and amorphous GeSbTe thin films

Pump-probe optical reflectivity and terahertz transmission measurements have been used to investigate time resolved sub-threshold photo-induced effects in crystalline and amorphous GeSbTe films at MHz repetition rates. The reflectivity in both phases exhibits long-lived modulations consistent with the sign of the changes that occur upon switching but of smaller magnitude. These can be understood by the generation of acoustic strains with the crystalline phase response dominated by thermal effects and the amorphous phase response associated with electronically induced changes. Evidence for a photo-induced distortion is observed in the amorphous phase which develops homogeneously within the excited region on few-picosecond time scales.
Media Frames for Black Bear Management Stories during Issue Emergence in New York

We completed a content analysis of newspaper, radio, and television reports (n = 117) available to people in New York State between January 1999 and March 2002, to characterize how news stories differed with regard to problem identification, attributions of responsibility, and proposed solutions to black bear management problems. Nearly all reports could be characterized as episodic rather than thematic (i.e., focused on specific events rather than general outcomes or conditions). Reports identified few bear-related problems, suggested few solutions to problems, and tended to attribute responsibility for solving problems to individuals, not government agencies. We suggest that wildlife managers make efforts to raise stakeholder awareness about a wider array of bear–human interactions and effects of interactions than are reported by mass media as management issues emerge. By improving media relations plans and investing in stakeholder issue education, wildlife agencies can enable communities to create frames for productive dialogue about black bear management.
A general framework for analysing diversity in science, technology and society

This paper addresses the scope for more integrated general analysis of diversity in science, technology and society. It proposes a framework recognizing three necessary but individually insufficient properties of diversity. Based on 10 quality criteria, it suggests a general quantitative non-parametric diversity heuristic. This allows the systematic exploration of diversity under different perspectives, including divergent conceptions of relevant attributes and contrasting weightings on different diversity properties. It is shown how this heuristic may be used to explore different possible trade-offs between diversity and other aspects of interest, including portfolio interactions. The resulting approach offers a way to be more systematic and transparent in the treatment of scientific and technological diversity in a range of fields, including conservation management, research governance, energy policy and sustainable innovation.
Breast cancer: The intention to have a mammography and a clinical breast examination - application of the theory of planned behavior

Abstract The purpose of these cross sectional studies was to identify the psychosocial factors explaining women's intention to have a mammography within the next two years and their intention to have a clinical breast examination (CBE) by a professional within the next year. Two random samples of women aged 40–69 years (na = 354, nb = 344) completed a self-administered questionnaire that investigated theoretical constructs of the theory of planned behavior. The results of structural equation modeling showed that subjective norms and perceived behavioral control explained 81 % of the variance in intention of having a mammography. Sixty-five percent (65%) of the variance in intention of having a CBE was explained by attitude and perceived behavioral control. In conclusion, women need to be better informed, have better skills to overcome psychological and physical barriers in performing preventive breast behaviors, and promotion of preventive breast cancer methods should consider people significant for women.
Partial Characterizations of 1‐Perfectly Orientable Graphs

We study the class of 1‐perfectly orientable graphs, that is, graphs having an orientation in which every out‐neighborhood induces a tournament. 1‐perfectly orientable graphs form a common generalization of chordal graphs and circular arc graphs. Even though they can be recognized in polynomial time, little is known about their structure. In this article, we develop several results on 1‐perfectly orientable graphs. In particular, we (i) give a characterization of 1‐perfectly orientable graphs in terms of edge clique covers, (ii) identify several graph transformations preserving the class of 1‐perfectly orientable graphs, (iii) exhibit an infinite family of minimal forbidden induced minors for the class of 1‐perfectly orientable graphs, and (iv) characterize the class of 1‐perfectly orientable graphs within the classes of cographs and of cobipartite graphs. The class of 1‐perfectly orientable cobipartite graphs coincides with the class of cobipartite circular arc graphs.
Young adults re‐enacting in psychotherapy their relationship with a mentally disturbed parent

The present study aims at exploring what characterizes psychoanalytic psychotherapy with young adults who grew up with a mentally disturbed parent, with regard to the following aspects: the therapeutic process; specific problems in the therapeutic collaboration; helpful and hindering factors; and patterns of transference and counter‐transference. All patient cases (n = 3) who had the specific family background of parental mental disorder were selected from a sample of 46 cases, in which patients and therapists were interviewed pre‐ and post‐therapy. Interviews with patients and therapists conducted at the onset of treatment and at its termination were analysed qualitatively. All patients had characteristic ways of acting in the relationship with the therapist that caused problems and hindered the therapeutic work. These behaviours probably evolved during childhood and adolescence in relation to the disturbed mother. These patterns could be interpreted as re‐enactments of early relationship themes. The therapists varied in their attention to, co‐enacting in, and ways of managing these enactments. The conclusion is that successful therapy seemed to be associated with the therapist enduring the patient's negative transference and accepting negative counter‐transference, and in so doing being able to detect the patient's re‐enactments and interpret those.
Combining 3D SLAM and visual tracking to reach and retrieve objects in daily-life indoor environments

In this paper, we draw perspectives to endow a humanoid robot with capabilities to reach known object in an indoor environment by combining continuous monitoring and building using SLAM and visual tracking. We integrates and exploits two key features: object recognition using the toolbox BLORT, and a SLAM (Simultaneous Localization And Mapping) software, that unifies volumetric 3D modeling and image-based key-frame modeling to be used in tracking. Using these two modules, we show that it is possible to reach a given object in the environment providing its model is registered and known. Our integration software is exemplified using a humanoid robot HRP-2, we present experimental results that illustrates the performance of our approach.
The Effectiveness of Three Inpatient Intervention Strategies for Chemically Dependent Women

Objective: This study investigated the effectiveness of three inpatient substance abuse intervention strategies for women: female-sensitive treatment, mixed-gender treatment, and combination mixed-gender/female-sensitive treatment. Method: Eighty-nine women in three treatment facilities were evaluated over a 3-month period on levels of self-esteem, social support, depression, and severity of addiction. It was hypothesized that (1) these women would exhibit lower levels of self-esteem and perceived social support and higher levels of depression compared to the median scores of each instrument and (2) women in all three groups would experience improvement on the outcome variables over the 3-month period, with the female-sensitive intervention producing the greatest improvement. Results: Results supported Hypothesis 1 for social support but not depression or self-esteem. Hypothesis 2 was not supported; none of the groups improved on any outcome measures. Conclusion: The results underscore the necessity for more research on effectiveness of various treatment approaches for chemically dependent women.
Analysis of multivariate recurrent event data with time‐dependent covariates and informative censoring

Multivariate recurrent event data are usually encountered in many clinical and longitudinal studies in which each study subject may experience multiple recurrent events. For the analysis of such data, most existing approaches have been proposed under the assumption that the censoring times are noninformative, which may not be true especially when the observation of recurrent events is terminated by a failure event. In this article, we consider regression analysis of multivariate recurrent event data with both time‐dependent and time‐independent covariates where the censoring times and the recurrent event process are allowed to be correlated via a frailty. The proposed joint model is flexible where both the distributions of censoring and frailty variables are left unspecified. We propose a pairwise pseudolikelihood approach and an estimating equation‐based approach for estimating coefficients of time‐dependent and time‐independent covariates, respectively. The large sample properties of the proposed estimates are established, while the finite‐sample properties are demonstrated by simulation studies. The proposed methods are applied to the analysis of a set of bivariate recurrent event data from a study of platelet transfusion reactions.
Dual-antenna based blind hostile jamming suppression and multi-user detection scheme for ds-cdma systems with unknown hostile jamming

The performance of direct-sequence code-division multiple access (DS-CDMA) systems may be significantly degraded if the system is severely jammed. In this paper, we propose a blind hostile jamming suppression and multi-user detection (MUD) scheme for the uplink of hostile jamming dominant DS-CDMA system. Based on using dual receive antennas, this scheme exploits the unknown spatial correlation of the jamming components between two antennas to eliminate the unknown hostile jamming and then performs MUD based independent component analysis (ICA). Simulation results demonstrate that the proposed scheme perform well in hostile jamming dominant scenario.
Insulin elicits a ROS-activated and an IP3-dependent Ca2+ release, which both impinge on GLUT4 translocation

ABSTRACT Insulin signaling includes generation of low levels of H2O2; however, its origin and contribution to insulin-stimulated glucose transport are unknown. We tested the impact of H2O2 on insulin-dependent glucose transport and GLUT4 translocation in skeletal muscle cells. H2O2 increased the translocation of GLUT4 with an exofacial Myc-epitope tag between the first and second transmembrane domains (GLUT4myc), an effect additive to that of insulin. The anti-oxidants N-acetyl L-cysteine and Trolox, the p47phox–NOX2 NADPH oxidase inhibitory peptide gp91-ds-tat or p47phox knockdown each reduced insulin-dependent GLUT4myc translocation. Importantly, gp91-ds-tat suppressed insulin-dependent H2O2 production. A ryanodine receptor (RyR) channel agonist stimulated GLUT4myc translocation and insulin stimulated RyR1-mediated Ca2+ release by promoting RyR1 S-glutathionylation. This pathway acts in parallel to insulin-mediated stimulation of inositol-1,4,5-trisphosphate (IP3)-activated Ca2+ channels, in response to activation of phosphatidylinositol 3-kinase and its downstream target phospholipase C, resulting in Ca2+ transfer to the mitochondria. An inhibitor of IP3 receptors, Xestospongin B, reduced both insulin-dependent IP3 production and GLUT4myc translocation. We propose that, in addition to the canonical &agr;,&bgr; phosphatidylinositol 3-kinase to Akt pathway, insulin engages both RyR-mediated Ca2+ release and IP3-receptor-mediated mitochondrial Ca2+ uptake, and that these signals jointly stimulate glucose uptake.
DIE WALL REACTION AND FRICTION DURING COMPACTION OF SOME DIRECT COMPRESSION BASE

To i n v e s t i g a t e t h i s p o i n t , Av ice l and o t h e r d i r e c t compression b a s e s were comp r e s s e d h y d r a u l i c a l l y i n a 2.54 cm d . d i e set v i t h chronied w a l l s and punch f a c e s . The d i e w a l l r e a c t i o n FR was o b t a i n e d a t v a r i o u s a x i a l f o r c e s FA by means o f a K i s t l e r lodd washer e x t e n d i n g round t h e d i e base . Th i s r e a c t i o n was p l o t t e d as i t developed v . punch d i s p l a c e w n t u s i n g a t r a n s d u c e r and XY p l o t t e r . The f o r c e t r a n s m i t t e d t o the bo t tom punch i s t h e n FA-FR = Fs. Values of t h e a p p a r e n t f r i c t i o n c o e f f i c i e n t p', between t h e compact and d i e w a l l w e r e c a l c u l a t e d from