Miracle-dz/UniFAR-FTUs huggingface dataset:
Cellulose nanocrystals : surface modification and advanced materials

The present work focuses on the properties of cellulose nanocrystals, their surface modification and development of advanced materials. Diverse approaches are employed on these nanoscaled substrates aiming to modify their surface properties and extend their use in highly sophisticated applications, such as postsulfation and desulfation, polymer grafting and adsorption, selective oxidation, molecular grafting, and ‘host-guest' inclusion. On the basis of surface modifications, properties analysis (for different sulfate group contents) and various nanomaterials derived from cellulose nanocrystals are investigated and prepared, including gradient sulfated nanocrystals, extruded nanocomposites, biocomposite sponges, and supramolecular hydrogels. The effect of gradient degrees of sulfate groups on cellulose nanocrystals to surface chemistry, morphology and physical properties are discussed, particularly four cross-section models are compared for the determination of the surface degree of substitution on cellulose nanocrystals. A novel strategy involving a double-polymer-layer shield and physical and/or chemical compatibilization of cellulose nanocrystals is proposed, in order to realize both improvement of thermal stability and promotion of compatibility for nanocrystals with non-polar polymeric matrices during processing by melt-extrusion. With the idea of participating as crosslinking aid for the construction of advanced materials, selectively oxidized cellulose nanocrystals (with oxidized microfibrillated cellulose as comparison) are introduced in alginate for the development of biocomposite sponges with improved mechanical stability or structural stability. Through the smart design of in situ ‘host−guest' inclusion between chemically modified cellulose nanocrystals and cyclodextrin, two hydrophilic polysaccharides are combined in supramolecular hydrogels for use as drug delivery. In a word, this dissertation contributes to the advances of cellulose nanocrystals in the topics of property analysis and application development.
Potato and french fry consumption and risk of type 2 diabetes in women.

BACKGROUND Potatoes, a high glycemic form of carbohydrate, are hypothesized to increase insulin resistance and risk of type 2 diabetes. OBJECTIVE The objective was to examine prospectively the relation between potato consumption and the risk of type 2 diabetes. DESIGN We conducted a prospective study of 84,555 women in the Nurses' Health Study. At baseline, the women were aged 34-59 y, had no history of chronic disease, and completed a validated food-frequency questionnaire. The participants were followed for 20 y with repeated assessment of diet. RESULTS We documented 4496 new cases of type 2 diabetes. Potato and french fry consumption were both positively associated with risk of type 2 diabetes after adjustment for age and dietary and nondietary factors. The multivariate relative risk (RR) in a comparison between the highest and the lowest quintile of potato intake was 1.14 (95% CI: 1.02, 1.26; P for trend = 0.009). The multivariate RR in a comparison between the highest and the lowest quintile of french fry intake was 1.21 (95% CI: 1.09, 1.33; P for trend < 0.0001). The RR of type 2 diabetes was 1.18 (95% CI: 1.03, 1.35) for 1 daily serving of potatoes and 1.16 (95% CI: 1.05, 1.29) for 2 weekly servings of french fries. The RR of type 2 diabetes for substituting 1 serving potatoes/d for 1 serving whole grains/d was 1.30 (95% CI: 1.08, 1.57). The association between potato consumption and risk of type 2 diabetes was more pronounced in obese women. CONCLUSIONS Our findings suggest a modest positive association between the consumption of potatoes and the risk of type 2 diabetes in women. This association was more pronounced when potatoes were substituted for whole grains.
The Constellation of Chronic Low Back Pain and Other Subjective Symptoms: Does the View Differ From China?

Study Design. This was a pilot, cross-sectional study. Its site was West China Hospital in Chengdu, Sichuan Province. Objective. An objective was to explore whether, in China, chronic low back pain (cLBP) characteristically is one symptom among co-occurring subjective symptoms. More basic objectives were to test a supplemented list of symptoms and to reconfigure findings from the literature on co-occurrence of symptoms so that they pertain specifically to cLBP. The governing metaphor was a constellation of symptoms in which cLBP is located. Summary of Background Data. With the exception of small, isolated societies, previous studies of co-occurrence of symptoms were conducted in the affluent West. Although China's population is larger than the combined populations of affluent countries of the West, research on co-occurring symptoms has been neglected in China. Unknown is whether results from studies conducted in the affluent West may be extended to China. Methods. A survey with the supplemented symptom list was cross-culturally adapted into Chinese and administered to cLBP patients (N = 72) and normal controls (N = 102). Multiple regression analysis was used to determine the effects of covariates (age, gender, education) on symptom reporting. Results. cLBP patients reported higher median numbers of symptoms than normal controls, including total symptoms (9 vs. 3), musculoskeletal symptoms (4 vs. 1), and nonmusculoskeletal symptoms (6 vs. 2.5); differences between cLBP and normal controls were highly significant (p < 0.001). Covariates had a little effect on symptom reporting. Conclusion. cLBP characteristically was one symptom in a constellation of symptoms. This finding came from one research site in China. Nevertheless, consistency between studies is notable, with findings from the affluent West supporting the finding from the Chinese site. The tendency to concentrate on a discrete clinical entity, cLBP itself, may obscure the constellation of symptoms. The more expansive view of cLBP has implications for clinical practice and research. Level of Evidence: N/A
Experimental Study on the Structural Performance of Poplar Laminated Veneer Lumber Beams

The processing method of laminated veneer lumber and LVL beams were explicated.The experimental study on the structural performance of the different design parameter poplar Laminated Veneer Lumber Beams were conducted,and the failure patterns,flexural strength and stiffness of the beams were studied.The paper analyzed the veneer thickness and the volume of LVL beams influencing the structural performance.The experimental results show that the failure patterns of LVL beams begin at the outmost timber fibre in the tension area and the LVL beam deflection is very big.The structural performance of LVL beam will improve with attenuation of the veneer thickness;the load absorption will improve with the increase of beam volume,but the bending strength will decrease with the increase of beam volume.The study shows that poplar LVL has a good prospect in the building structures of China.
Comparison of nutritional and inflammatory markers in dialysis patients with reduced appetite.

BACKGROUND Anorexia is common in chronic kidney disease and worsens as the disease progresses. Sex hormones and inflammatory cytokines may be related to feeding behavior. OBJECTIVE We hypothesized that appetite would be related to inflammation and outcome in hemodialysis patients but that sex may account for differences in the symptoms associated with poor appetite. DESIGN A cross-sectional study was conducted in patients undergoing prevalent hemodialysis (n = 223; 127 M; x +/- SD age: 66 +/- 14 y). Anthropometric markers of body composition, handgrip strength, and nutritional and inflammatory status were measured, and 3 groups according to their self-reported appetite were established. Overall mortality was assessed after 19 mo (range: 2-29 mo) of follow-up. RESULTS Poor appetite was associated with a longer vintage time, increased inflammation (higher serum concentrations of interleukin 6 and C-reactive protein), and a worse nutritional status (lower serum concentrations of insulin-like growth factor I, albumin, urea, and creatinine). However, across worsening appetite scale, handgrip strength was incrementally lower in men but not in women (multivariate analysis of variance). In a multivariate logistic regression analysis (pseudo r(2) = 0.19), appetite loss was associated with sex [odds ratio (OR): 0.41; 95% CI: 0.24, 0.72], insulin-like growth factor I (3.58; 2.10, 6.32), and C-reactive protein > 10 mg/L (2.39; 1.34, 4.11). Finally, appetite loss was associated with worse clinical outcome even after adjustment for age, sex, inflammation, dialysis vintage, and comorbidity (likelihood ratio = 44.3; P < 0.0001). CONCLUSIONS These results show a close association among appetite, malnutrition, inflammation, and outcome in patients undergoing prevalent hemodialysis. Moreover, our data suggest that uremic men may be more susceptible than are women to inflammation-induced anorexia.
Effect of dairy calcium or supplementary calcium intake on postprandial fat metabolism, appetite, and subsequent energy intake.

BACKGROUND High calcium intake has been shown to increase fecal fat excretion. OBJECTIVE Our aim was to examine whether a high calcium intake from dairy products or from supplements affects postprandial fat metabolism and appetite through fat malabsorption. DESIGN Four different isocaloric meals were tested in 18 subjects according to a randomized crossover design. The test meals contained high (HC meal: 172 mg/MJ), medium (MC meal: 84 mg/MJ), or low (LC meal: 15 mg/MJ) amounts of calcium from dairy products or a high amount of calcium given as a calcium carbonate supplement (Suppl meal: 183 mg/MJ). Concentrations of plasma total triacylglycerol, chylomicron triacylglycerol, serum total cholesterol, HDL cholesterol, cholecystokinin, glucagon-like peptide 1, ghrelin, peptide YY, glucose, and insulin and appetite sensation were measured before and at regular intervals until 420 min postprandially. RESULTS Dairy calcium significantly diminished the postprandial lipid response. The baseline adjusted area under the curve for chylomicron triacylglycerol was approximately 17% lower after the MC meal (P = 0.02) and approximately 19% lower after the HC meal (P = 0.007) than after the LC meal and approximately 15% lower after the MC meal (P = 0.0495) and approximately 17% lower after the HC meal (P = 0.02) than after the Suppl meal. No consistent effects of calcium on appetite sensation, or on energy intake at the subsequent meal, or on the postprandial responses of cholecystokinin, glucagon-like peptide 1, ghrelin, peptide YY, insulin, or glucose were observed. CONCLUSIONS Increased calcium intakes from dairy products attenuate postprandial lipidemia, most probably because of reduced fat absorption, whereas supplementary calcium carbonate does not exert such an effect. This may be due to differences in the chemical form of calcium or to cofactors in dairy products. Calcium did not affect appetite sensation, glucose metabolism, or gut hormone secretion.
A Software Architecture to Support Misuse Intrusion Detection

Misuse Intrusion Detecl.ion has traditionally been understood in the literature as the detection of specific, precisely representable techniques of computer system abuse. Pattern matching is well disposed to the representation and detection of such abuse. Each specific method of abuse can be represented as a pattern and many of these can be matched simultaneously against the audit logs generated by the as kernel. Using relatively high level patterns to specify computer system abuse relieves the pattern writer from having to understand and encode the intricacies of pattern matching into a misuse detector. Patterns represent. a declarative way ofspecifying what needs Lo be detected, instead of specifying how it should be detected. We have devised a model of matching based on Colored Petri Nets specifically targeted for misuse intrusion detection. In this paper we present a software architecture for structuring a pattern matching solution to misuse intrusion detection. In the context of an object oriented prototype implementation we describe the abstract classes encapsulating generic functionality and the inter-relationships between the classes.
Associations between healthy eating patterns and immune function or inflammation in overweight or obese postmenopausal women.

BACKGROUND The link between poor nutritional status and impaired immune function is well established; however, most studies have focused on individual nutrients instead of overall dietary patterns. OBJECTIVE Our objective was to investigate associations between 3 indexes of overall diet quality [the Diet Quality Index (DQI), the DQI including supplementary calcium (DQI-Ca), and the Healthy Eating Index (HEI)] and biomarkers of inflammation and immunity. DESIGN This cross-sectional study included 110 overweight or obese postmenopausal women. Dietary intake measured by food-frequency questionnaire was used to calculate diet quality scores. C-reactive protein (CRP) and serum amyloid A (SAA) were measured by latex-enhanced nephelometry. Flow cytometry was used to measure natural killer (NK) cell cytotoxicity and to enumerate and phenotype lymphocyte subsets. T lymphocyte proliferation was assessed by (3)H-thymidine incorporation as well as by the carboxyfluorescein-succinimidyl ester method of cell division tracking. Multivariable-adjusted linear regression analysis was used to investigate associations between diet quality scores and markers of inflammation and immune function. RESULTS Higher diet quality was associated with increased proportions of cytotoxic and decreased proportions of helper T lymphocytes. CRP and SAA concentrations were higher among women with a lower-quality diet; these associations became nonsignificant after adjustment for body mass index or percentage body fat. We observed limited evidence for an association between healthy eating patterns and greater lymphocyte proliferation and no evidence for an association with NK cell cytotoxicity. CONCLUSION Our results provide limited evidence that healthy eating patterns contribute to enhanced immune function and reduced inflammation in overweight and obese postmenopausal women.
This message will self-destruct: Self-easing covert communication

The WWW increasingly allows people to create and update content for public access. Some of this information is collaboratively owned (created and maintained), while other information is privately owned and maintained (but still publicly accessible). Whereas it is unethical to modify the former for covert communication, it is quite legitimate to do so with the latter, and this paper gives a design for doing so while achieving both plausible deniability and automatic perishability of the covert message (the message disappears unless periodically refreshed by the encoder). Traditional information-hiding has looked at the problem of embedding a message in a static version of an online document, the problem of doing so for rapidly evolving document collections has not been considered in the past. This paper shows that it is possible to do so, and in a manner that actually makes use of the rapidly evolving nature of the documents to achieve the above-mentioned property of evanescence: That the message decays over time and eventually becomes completely erased unless it is refreshed. Therefore the mark needs to be continuously maintained as the document evolves, in a manner that prevents the adversary from knowing who is doing the refreshing yet that allows the intended reader of the mark to recover it without any form of explicit communication. One advantage of our scheme is that the mark's reach is now unbounded: It can be read by any authorized entity on the web (anyone with the secret key), and the reading of it is indistinguishable from normal web access patterns. Another advantage is the "hiding in the crowd" effect: Many people are updating the documents, thereby providing a cover for the one person surreptitiously injecting and refreshing the mark, or replacing it with another mark message. We have also demonstrated the feasibility of the proposed technique, and shown that remarkably little effort is required to implement our scheme over today's web. "Portions of this work were supported by Grants IIS0325345, IIS-0219560, IIS-0312357, and IIS-0242421 from the National Science Foundation, and by sponsors of the Center for Education and Research in Information Assurance and Security. t: ti . t t t i i it t tt , , , j , , t .
Pareto evolutionary neural networks

For the purposes of forecasting (or classification) tasks neural networks (NNs) are typically trained with respect to Euclidean distance minimization. This is commonly the case irrespective of any other end user preferences. In a number of situations, most notably time series forecasting, users may have other objectives in addition to Euclidean distance minimization. Recent studies in the NN domain have confronted this problem by propagating a linear sum of errors. However this approach implicitly assumes a priori knowledge of the error surface defined by the problem, which, typically, is not the case. This study constructs a novel methodology for implementing multiobjective optimization within the evolutionary neural network (ENN) domain. This methodology enables the parallel evolution of a population of ENN models which exhibit estimated Pareto optimality with respect to multiple error measures. A new method is derived from this framework, the Pareto evolutionary neural network (Pareto-ENN). The Pareto-ENN evolves a population of models that may be heterogeneous in their topologies inputs and degree of connectivity, and maintains a set of the Pareto optimal ENNs that it discovers. New generalization methods to deal with the unique properties of multiobjective error minimization that are not apparent in the uni-objective case are presented and compared on synthetic data, with a novel method based on bootstrapping of the training data shown to significantly improve generalization ability. Finally experimental evidence is presented in this study demonstrating the general application potential of the framework by generating populations of ENNs for forecasting 37 different international stock indexes.
Aging, protein requirements, and protein turnover.

Current protein requirements for the elderly derive from 1985 FAO/WHO/UNU recommendations of no change with age in adults: i.e., 0.6 g/kg average and 0.75 g/kg safe allowance. Although concern has been expressed that protein requirements for the elderly may be greater, a review of nitrogen balance data, none of which are entirely satisfactory, indicates little reason for any revision. Furthermore, the 1985 recommendation is generally consistent with reports that the rate of whole-body protein turnover, a commonly assumed determinant of the protein requirement, exhibits minimal change with age per unit fat-free mass. Recent novel tracer studies aimed at evaluating protein requirements and turnover in a systematic way also support the 1985 recommendations. [1-13C]leucine balance studies have allowed measurement of metabolic demand from postabsorptive leucine oxidation and the efficiency of protein utilization from changes in leucine balance with feeding. The apparent protein requirement is metabolic demand divided by efficiency, an indication of protein needs and utilization during a standardized protocol at intakes similar to habitual ones. In healthy, mobile, elderly persons, metabolic demands are reduced by about one-third, with no significant impairment in efficiency of protein utilization. Thus, apparent protein requirements appear to fall with age from 0.98 +/- 0.17 to 0.69 +/- 0.22 g/kg. These changes with age reflect an improved restraint of proteolysis in the postabsorptive state, with little change with age in whole-body protein synthesis. The requirements of frail and immobile elderly and the efficiency of protein utilization of meals as eaten by elderly people remain to be evaluated.
Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis.

BACKGROUND It has been suggested that a high dietary intake and high circulating concentrations of vitamin C may protect against ischemic heart disease. OBJECTIVES The objective was to examine the associations between dietary and plasma vitamin C concentrations, fruit and vegetable intakes, and markers of inflammation and hemostasis associated with cardiovascular disease in older men free of cardiovascular disease. DESIGN This cross-sectional study examined 3258 men aged 60-79 y with no physician diagnosis of myocardial infarction, stroke, or diabetes and who were drawn from general practices in 24 British towns. Fruit and vegetable intakes and dietary vitamin C were assessed by using a food-frequency questionnaire. RESULTS Plasma vitamin C, fruit intake, and dietary vitamin C intake were significantly and inversely associated with mean concentrations of C-reactive protein, an acute phase reactant, and tissue plasminogen activator (t-PA) antigen, a marker of endothelial dysfunction, even after adjustment for confounders. Vegetable intake was correlated significantly (inversely) only with t-PA. For plasma vitamin C (highest versus lowest quartile), the adjusted odds of elevated C-reactive protein and t-PA (highest tertile versus lowest tertile) were 0.56 (95% CI: 0.44, 0.71) and 0.79 (0.62, 1.00); for fruit intake, the corresponding odds ratios were 0.76 (0.60, 0.95) and 0.76 (0.61, 0.95). Plasma (but not dietary) vitamin C also showed inverse associations with both fibrinogen concentrations and blood viscosity. No associations were seen with von Willebrand factor or factor VIII. CONCLUSION The findings suggest that vitamin C has antiinflammatory effects and is associated with lower endothelial dysfunction in men with no history of cardiovascular disease or diabetes.
GLAST Deficiency in Mice Exacerbates Gap Detection Deficits in a Model of Salicylate-Induced Tinnitus

Gap detection or gap pre-pulse inhibition of the acoustic startle (GPIAS) has been successfully used in rat and guinea pig models of tinnitus, yet this system has been proven to have low efficacy in CBA mice, with low basal GPIAS and subtle tinnitus-like effects. Here, we tested five mouse strains (CBA, BalbC, CD-1, C57BL/6 and 129sv) for pre-pulse inhibition (PPI) and gap detection with varying interstimulus intervals (ISI) and found that mice from a CBA genetic background had the poorest capacities of suppressing the startle response in the presence of a pre-pulse or a gap. CD-1 mice displayed variable responses throughout all ISI. Interestingly, C57BL/6, 129sv and BalbC showed efficient suppression with either pre-pulses or gaps with shorter ISI. The glutamate aspartate transporter (GLAST) is expressed in support cells from the cochlea and buffers the excess of glutamate. We hypothesized that loss of GLAST function could sensitize the ear to tinnitus-inducing agents, such as salicylate. Using shorter ISI to obtain a greater dynamic range to assess tinnitus-like effects, we found that disruption of gap detection by salicylate was exacerbated across various intensities of a 32-kHz narrow band noise gap carrier in GLAST knockout (KO) mice when compared to their wild-type (WT) littermates. Auditory brainstem responses (ABR) and distortion-product otoacoustic emission (DPOAE) were performed to evaluate the effects on hearing functions. Salicylate caused greater auditory threshold shifts (near 15 dB) in GLAST KO mice than in WT mice across all tested frequencies, despite similarly reduced DPOAE. Despite these changes, inhibition using broad-band gap carriers and 32 kHz pre-pulses were not affected. Our study suggests that GLAST deficiency could become a useful experimental model to decipher the mechanisms underlying drug-induced tinnitus. Future studies addressing the neurological correlates of tinnitus in this model could provide additional insights into the mechanisms of tinnitus.