Miracle-dz/UniFAR-FTUs huggingface dataset:
Boost Movie Ticket Sales by Location-Based Advertising: A Bayesian VAR Approach

ABSTRACT Compared to previous research studying movie advertising focusing on traditional advertising, this study introduce location-based ads (LBA), an important new media advertising, to raise limited coverage of traditional movie advertising. This study explores the role of LBA in generating ticket sales dynamically and compares it with that of pop-up window ads (PWA). Using daily aggregate cinema sales data on about three million consumers, developed time-series models reveal that (a) LBA can affect ticket sales in short and long terms, and its sales impact can last for 9 days across audience segments; (b) compared to low involvement audience segments, sales impact of LBA is 15 times larger for high involvement audience segment in long term; (c) ticket sales impact of LBA are cumulatively 3 times and 47 times stronger than those of PWA in low involvement audience segment and high involvement audience segment, respectively.
Proteomics of Mouse BRCA1-deficient Mammary Tumors Identifies DNA Repair Proteins with Potential Diagnostic and Prognostic Value in Human Breast Cancer*

Breast cancer 1, early onset (BRCA1) hereditary breast cancer, a type of cancer with defects in the homology-directed DNA repair pathway, would benefit from the identification of proteins for diagnosis, which might also be of potential use as screening, prognostic, or predictive markers. Sporadic breast cancers with defects in the BRCA1 pathway might also be diagnosed. We employed proteomics based on one-dimensional gel electrophoresis in combination with nano-LC-MS/MS and spectral counting to compare the protein profiles of mammary tumor tissues of genetic mouse models either deficient or proficient in BRCA1. We identified a total of 3,545 proteins, of which 801 were significantly differentially regulated between the BRCA1-deficient and -proficient breast tumors. Pathway and protein complex analysis identified DNA repair and related functions as the major processes associated with the up-regulated proteins in the BRCA1-deficient tumors. In addition, by selecting highly connected nodes, we identified a BRCA1 deficiency signature of 45 proteins that enriches for homology-directed DNA repair deficiency in human gene expression breast cancer data sets. This signature also exhibits prognostic power across multiple data sets, with optimal performance in a data set enriched in tumors deficient in homology-directed DNA repair. In conclusion, by comparing mouse proteomes from BRCA1-proficient and -deficient mammary tumors, we were able to identify several markers associated with BRCA1 deficiency and a prognostic signature for human breast cancer deficient in homology-directed DNA repair.
Lipopolysaccharide-Free Conditions in Primary Allow Growth and Isolation of Microglial Cells Astrocyte Cultures

Primary rat astrocyte cultures were used to isolate a macrophage population that does not adhere to the confluent glial cells. The cells multiplied vigorously in coculture with astrocytes during the 14 d culture period, provided that functionally active lipopolysaccharide (LPS) was either absent or present in very low concentrations. Based on morphological, immunocytochemical, and pharmacological data, it was concluded that the isolated cells were microglia, the resident macrophages of the brain. The findings characterized them as a distinct cell population that shares features both of peritoneal macrophages and of astroglial cells. Like peritoneal macrophages, the isolated cells were able to phagocytire as shown by their ingestion of latex beads and uptake of L-leucyl methylester. Furthermore, they were immunocytochemically stainable by a specific monoclonal antibody (ED 1) against a macrophage-specific antigen (Dijkstra et al., 1985). They also synthesized prostaglandin E, (PGE,) and secreted interleukin 1 (IL-l) upon stimulation with LPS. Upon stimulation with the ionophore A231 87, PGD,, the predominant prostaglandin of the brain, was the major PG metabolite released by these cells. In contrast to peritoneal macrophages, microglial cells were able to multiply. Proliferation of microglial cells in coculture with astrocytes was suppressed when 2 ng LPS/ml or higher concentrations were added to astroglial culture media. These astrocyte cultures, which contained approximately 1% microglia, were used to investigate the influence of LPS on prostaglandin and IL-1 secretion in order to compare astroglial and microglial features. Increasing LPS concentrations induced increased PGE, secretion, whereas PGD, secretion was essentially unaffected by LPS. The critical influence of LPS contaminations in most of the commercially available animal sera used for astrocyte cultures on cellular composition in general and on metabolism of hormones and growth factors in particular is discussed.
Effect of Social Networking Advertisements on Shaping Consumers’ Attitude

The purpose of this research article is to propose and test a model showing the impact of three positive attributes of social networking advertisements (SNAs) on the generation of positive attitude of the viewers. The model is further used to empirically test the impact of the generated positive attitude towards the SNAs on purchase intention and word-of-mouth (WOM) intention. Online survey was conducted to collect relevant data using structured questionnaire, which was subsequently subjected to structural equation modelling (SEM) using the statistical software AMOS 18. The study shows that SNAs which incorporate three positive attributes, entertainment, information and credibility, result in generation of positive attitude towards the SNAs. Also, once a positive attitude towards the SNAs has been generated, it further results in generation of purchase intention and WOM intention. The present study aims to contribute to the body of knowledge, and help the brand advertisers to design and present SNAs to generate favourable cognitive and behavioural responses from the consumers.
Diagnosis of pulmonary hydatid disease presenting with solid nodule and mimicking malignancy by fine needle aspiration cytology

To the Editor, Hydatid disease (HD) is caused by Echinococcus granulosus, endemic in the cattle- and sheep-raising regions of the underdeveloped and developed world. [1,2] The prevalence is rather high in several countries of the Mediterranean region, mainly in pastoral areas where the dog-sheep cycle of the parasite prevails. [3] It also remains a health problem in Turkey, mainly in the rural areas of the eastern part of the country. [4] Hydatid disease predominantly affects the liver and lungs. The relatively rare anatomic locations are the central nervous system, muscles, subcutaneous tissue, kidneys, bones, and body cavities. [1] Pulmonary HD can be diagnosed by clinical and radiological findings, and serological analysis. However, old, arrested forms of the infection presenting with an organized, solid, atypical pulmonary nodule may mimic lung cancer. [5] Fine needle aspiration cytology (FNAC) can be a useful tool in the differential diagnosis. [6] We report a case of pulmonary hydatid cyst presenting with a solid and solitary nodule, clinically and radiologically suspicious for malignancy, diagnosed by FNAC. A 52-year-old female patient presented with a history of dyspnea and cough. Computed tomography (CT) revealed a solid nodular lesion, with a 2 cm diameter, in the apicoposterior segment of the upper lobe of the left lung [Figure 1]. Figure 1 Computed tomography image showing a nodular lesion (red arrow), 2 cm in diameter, in the apicoposterior segment of the upper lobe of the left lung A clinical and radiological diagnosis of lung malignancy was rendered, and subsequently a CT-guided transthoracic FNAC was done.
Ankle laxity: stress investigation under MRI control.

OBJECTIVE The purpose of this study was to examine the advantages of MRI-guided ankle stress examinations in the detection of chronic ankle instability. SUBJECTS AND METHODS An MRI-compatible stress device was developed and tested for MRI safety. Bilateral MRI stress examinations were performed on 50 volunteers with and without clinically evident subjective instability of the ankle joints (72 subjective stable ankle joints in 37 subjects, 28 ankles in 15 subjects with chronic ankle instability). Both the inversion test and the anterior drawer test were performed under axial, coronal, 45° paraxial, and sagittal T2-weighted fast spin-echo image control. MR images were assessed for talar tilt, subtalar tilt, anterior talus translation, anterior calcaneus translation, medial talocalcaneal translation, and the diameters of the lateral ankle ligaments (anterior talofibular ligament, calcaneofibular ligament, and posterior talofibular ligament). RESULTS The MRI stress device was found suitable and safe for use in the MRI environment. The talocrural and subtalar joints could be assessed simultaneously. Significant differences between groups A and B (p≤0.05) were found in talar tilt, subtalar tilt, anterior talus translation, anterior calcaneus translation, medial talocalcaneal translation, and decrease in diameters of calcaneofibular and posterior talofibular ligaments. Also found were sex differences in talar tilt, subtalar tilt, anterior talus translation, and diameters of the anterior talofibular, calcaneofibular, and posterior talofibular ligaments. Significant relations were found between talar tilt and anterior talus translation, subtalar tilt and anterior calcaneus translation, subtalar tilt and medial talocalcaneal translation, and between anterior calcaneus translation and medial talocalcaneal translation in groups A and B. CONCLUSION Stress examination under MRI control has advantages in the assessment of mechanical ankle instability. Additional diagnostic and clinically relevant information is obtained through direct imaging of the ligaments and assessment of additional parameters of ankle laxity (subtalar tilt, anterior calcaneus translation, medial talocalcaneal translation). The main advantages are objective imaging and measurement of abnormal looseness of the lower ankle joint and its direct simultaneous comparison with the upper ankle joint.
Correlations of ADHD symptoms with neurometabolites measured by 1H magnetic resonance spectroscopy.

OBJECTIVES Despite the number of studies on neurometabolite changes in ADHD (Attention deficit/hyperactivity disorder), there is lack of evidence on neurometabolite associations with ADHD symptoms. BACKGROUND We aimed to find the correlations of neurometabolites with ADHD symptoms. METHODS Twenty ADHD children were examined by means of 1H-MRS. The spectra were taken from dorsolateral prefrontal cortex (DLPFC) and white matter behind DLPFC, bilaterally. Neurometabolites were correlated with ADHD-RS-IV (ADHD-Rating Scales IV), CPRS (Conners Parent rating Scale) and DPREMB (Daily Parent Rating of Evening and Morning Behavior) scores. RESULTS NAA/Cr (N-acetylaspartate/creatine) in the right DLPFC positively correlated with CPRS subscale IV learning problems and negatively correlated in the left white matter with DPREMB morning behavior subscale and ADHD-RS-IV score. Glx/Cr (glutamate + glutamine/creatine) positively correlated in the right white matter with ADHD-RS-IV and negatively correlated in the left white matter with DPREMB morning behavior subscale score. Cho/Cr (choline/creatine) in the left white matter negatively correlated with DPREMB morning behavior subscale and ADHD-RS-IV score. CONCLUSION ADHD symptoms could result from different activities of the left- and right-hemisphere prefrontal circuits. In consequence to impulses to novel task searching the increased right prefrontal circuit activity could be mediated by different motivational control (Fig. 9, Ref. 73).
Leadership and Culture Climate: Exploring how School Principals Support Teacher Wellbeing

If a teacher is stressed out, they risk altering their wellbeing and capacity to teach effectively. Inevitably, this can impact lesson delivery and student engagement. This study explores teacher wellbeing in the context of administrative support from school leaders. As an under researched area in the literature, this study hopes to contribute findings on what effective school leaders do to maintain the wellbeing of their staff. Although stress is a personal matter, this study explores occupational stress in the context of factors that are attributed to the workplace of a school. This qualitative research project examines how two elementary school principals manage their schooland most importantly their teachersto ensure staff are in the right mental state to be effective teachers. Data was collected via a semi-structured interview protocol. Audio recordings of these interviews were transcribed, coded, and analysed. Results of this study suggest that there are two broad methods to maintain teacher wellbeing and a positive school climate. These are: proactive strategies and reactive strategies. The data suggest that proactive strategies, such as authentic communication, building a foundation of culture management and professional development can aid in maintaining teacher wellbeing in their workplace. The data further supports the notion of reactionary measures, where the participants described methods such as internal school support (such as mentorship) and external school support (such as board-level policy).
Renewable energy sources as an attractive element of industrial tourism

This paper deals with the overview of the interaction of tourism and renewable energy sources, and evaluates their potential regarding tourism industry as well as in terms of increasing of tourism attractiveness in the selected area. Renewable energy sources can be considered an attractive element within the industrial tourism and, in some cases, can increase the number of visitors to the area, mainly due to its modern design, proportions, eco-image and, in certain regions, due to its uniqueness. In analysis, interactions of renewable energy and tourism were classified into four categories. The analysis showed that the touristic subjects connected to the sensitively selected and located type of renewable energy source could have significant numbers of visitors in tens of thousands. According to results of the analysis, the highest number of visitors reached the visitor centres next to geothermal power plants and wind parks, which can be explained by their unique visual aspects. The paper also analysed the possible impact of the renewable energy infrastructure on tourists, when available studies indicate the minimal impact of installation if the power plants are sensibly placed in the country regarding location or distance from considered subject.
Measurement of craniovertebral angle by the Modified Head Posture Spinal Curvature Instrument: A reliability and validity study

ABSTRACT The Modified Head Posture Spinal Curvature Instrument (MHPSCI) is an extension of the Head Posture Spinal Curvature Instrument. Two specific modifications were made in the original design by adding a third arm projecting horizontally from the protractor to objectively fix the pivot exactly over the C7 vertebra and the addition of a spirit-level to properly align the instrument. In order to demonstrate reliability and validity, this study was conducted using patients with postural neck pain (N = 65) and healthy subjects (N = 20). All the subjects were working at a selected Information Technology Industry in India and had been recruited using a criterion-based sampling approach. The craniovertebral (CV) angle of each subject was evaluated by two raters consecutively. The measurements were taken by using both MHPSCI and the standard photographic method in a standardized sitting posture for the purpose of establishing criterion-validity of the instrument. The results of this study indicate a good inter-rater reliability (ICC = 0.76; CI = 0.65–0.84) as well as intra-rater reliability (ICC = 0.87; CI = 0.82–0.91) between three successive CV angle measurements (with 2 minutes interval between each measurement) through MHPSCI. While keeping the digital photographic measurement as a standard, this study established that the MHPSCI is a valid tool for measuring the CV angle as shown by non-significant difference (p > 0.01) and high correlation between the two methods (r = 0.79–0.84). This study demonstrates that the MHPSCI is a reliable and valid instrument for measuring CV angle in subjects with or without postural neck pain.
A High Content in Lipid-modified Peripheral Proteins and Integral Receptor Kinases Features in the Arabidopsis Plasma Membrane Proteome*S

The proteomics of plasma membrane has brought to date only scarce and partial information on the actual protein repertoire. In this work, the plant plasma membrane proteome of Arabidopsis thaliana was investigated. A highly purified plasma membrane fraction was washed by NaCl and Na2CO3 salts, and the insoluble fractions were further analyzed by nano-LC-MS/MS. With 446 proteins identified, we hereby describe the largest plasma membrane proteome diversity reported so far. Half of the proteins were predicted to display transmembrane domains and/or to be anchored to the membrane, validating a posteriori the pertinence of the approach. A fine analysis highlighted two main specific and novel features. First, the main functional category is represented by a majority of as yet unreported signaling proteins, including 11% receptor-like kinases. Second, 16% of the identified proteins are predicted to be lipid-modified, specifically involving double lipid linkage through N-terminal myristoylation, S-palmitoylation, C-terminal prenylation, or glycosylphosphatidylinositol anchors. Thus, our approach led for the first time to the identification of a large number of peripheral proteins as part of the plasma membrane and allowed the functionality of the plasma membrane in the cell context to be reconsidered.
Designing syntactic pattern classifiers using vector quantization and parametric string editing

We consider a fundamental inference problem in syntactic pattern recognition (PR). We assume that the system has a dictionary which is a collection of all the ideal representations of the objects in question. To recognize a noisy sample, the system compares it with every element in the dictionary based on a nearest-neighbor philosophy, using three standard edit operations: substitution, insertion, and deletion, and the associated primitive elementary edit distances d(.,.). In this paper, we consider the assignment of the inter-symbol distances using the parametric distances. We show how the classifier can be trained to get the optimal parametric distance using vector quantization in the meta-space. In all our experiments, the training was typically achieved in a very few iterations. The subsequent classification accuracy we obtained using this single-parameter scheme was 96.13%. The power of the scheme is evident if we compare it to 96.67%, which is the accuracy of the scheme which uses the complete array of inter-symbol distances derived from a knowledge of all the confusion probabilities.
Thromboprophylaxis in cancer patients with central venous catheters

Summary It was the aim of the review to determine the risks and benefits of primary thromboprophylaxis with anticoagulants in cancer patients with central venous devices. Medline, Central and Google Scholar databases were searched for randomized controlled trials (RCTs) in June 2006.Two reviewers extracted data and appraised the quality of RCTs. Results were expressed as relative risk (RR) with 95% confidence intervals (CI) using random effects model for the outcomes of catheter-related thrombosis, bleeding and thrombocytopenia. Eight RCTs (1,428 patients) were included. There was no statistically significant difference in the risk of catheter-related thrombosis for the use of warfarin versus placebo (3 trials, 425 patients, RR 0.75, 95% CI 0.24–2.35,p=0.63),heparin versus placebo (4 trials,886 patients, RR 0.46 95% CI 0.18–1.20, p=0.06) or warfarin, unfractionated heparin or low-molecular-weight heparin versus placebo (7 trials, 1,311 patients, RR 0.59, 95% CI 0.31–1.13, p=0.11). Substantial statistical heterogeneity was noted among these trials (I2>50%). The use of anticoagulants showed no statistically significant difference in the risk of overall bleeding (5 trials, 1,193 patients, RR 1.24, 95% CI 0.84–1.82, p=0.28), and thrombocytopenia for heparin versus placebo (4 trials, 958 patients, RR 0.85, 95% CI 0.49, 1.46, p=0.55) without any statistical heterogeneity (I2=0%). In cancer patients with central venous devices, thromboprophylaxis has no significant effect on the risk of catheter related thrombosis or bleeding. The use of primary thromboprophylaxis in cancer patients with central venous catheters while not causing any harm provides no benefit.
Date Fruits (Phoenix dactylifera Linn): An Emerging Medicinal Food

Date palm is one of the oldest trees cultivated by man. In the folk-lore, date fruits have been ascribed to have many medicinal properties when consumed either alone or in combination with other herbs. Although, fruit of the date palm served as the staple food for millions of people around the world for several centuries, studies on the health benefits are inadequate and hardly recognized as a healthy food by the health professionals and the public. In recent years, an explosion of interest in the numerous health benefits of dates had led to many in vitro and animal studies as well as the identification and quantification of various classes of phytochemicals. On the basis of available documentation in the literature on the nutritional and phytochemical composition, it is apparent that the date fruits are highly nutritious and may have several potential health benefits. Although dates are sugar-packed, many date varieties are low GI diet and refutes the dogma that dates are similar to candies and regular consumption would develop chronic diseases. More investigations in these areas would validate its beneficial effects, mechanisms of actions, and fully appreciate as a potential medicinal food for humans all around the world. Therefore, in this review we summarize the phytochemical composition, nutritional significance, and potential health benefits of date fruit consumption and discuss its great potential as a medicinal food for a number of diseases inflicting human beings.