Miracle-dz/UniFAR-FTUs huggingface dataset:
JUNLP at IJCNLP-2017 Task 3: A Rank Prediction Model for Review Opinion Diversification

IJCNLP-17 Review Opinion Diversification (RevOpiD-2017) task has been designed for ranking the top-k reviews of a product from a set of reviews, which assists in identifying a summarized output to express the opinion of the entire review set. The task is divided into three independent subtasks as subtask-A,subtask-B, and subtask-C. Each of these three subtasks selects the top-k reviews based on helpfulness, representativeness, and exhaustiveness of the opinions expressed in the review set individually. In order to develop the modules and predict the rank of reviews for all three subtasks, we have employed two well-known supervised classifiers namely, Naïve Bayes and Logistic Regression on the top of several extracted features such as the number of nouns, number of verbs, and number of sentiment words etc from the provided datasets. Finally, the organizers have helped to validate the predicted outputs for all three subtasks by using their evaluation metrics. The metrics provide the scores of list size 5 as (0.80 (mth)) for subtask-A, (0.86 (cos), 0.87 (cos d), 0.71 (cpr), 4.98 (a-dcg), and 556.94 (wt)) for subtask B, and (10.94 (unwt) and 0.67 (recall)) for subtask C individually.
An augmented reality system for patient-specific guidance of cardiac catheter ablation procedures

We present a system to assist in the treatment of cardiac arrhythmias by catheter ablation. A patient-specific three-dimensional (3-D) anatomical model, constructed from magnetic resonance images, is merged with fluoroscopic images in an augmented reality environment that enables the transfer of electrocardiography (ECG) measurements and cardiac activation times onto the model. Accurate mapping is realized through the combination of: a new calibration technique, adapted to catheter guided treatments; a visual matching registration technique, allowing the electrophysiologist to align the model with contrast-enhanced images; and the use of virtual catheters, which enable the annotation of multiple ECG measurements on the model. These annotations can be visualized by color coding on the patient model. We provide an accuracy analysis of each of these components independently. Based on simulation and experiments, we determined a segmentation error of 0.6 mm, a calibration error in the order of 1 mm and a target registration error of 1.04 /spl plusmn/ 0.45 mm. The system provides a 3-D visualization of the cardiac activation pattern which may facilitate and improve diagnosis and treatment of the arrhythmia. Because of its low cost and similar advantages we believe our approach can compete with existing commercial solutions, which rely on dedicated hardware and costly catheters. We provide qualitative results of the first clinical use of the system in 11 ablation procedures.
Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome

Background Neurologic Post Treatment Lyme disease (nPTLS) and Chronic Fatigue (CFS) are syndromes of unknown etiology. They share features of fatigue and cognitive dysfunction, making it difficult to differentiate them. Unresolved is whether nPTLS is a subset of CFS. Methods and Principal Findings Pooled cerebrospinal fluid (CSF) samples from nPTLS patients, CFS patients, and healthy volunteers were comprehensively analyzed using high-resolution mass spectrometry (MS), coupled with immunoaffinity depletion methods to reduce protein-masking by abundant proteins. Individual patient and healthy control CSF samples were analyzed directly employing a MS-based label-free quantitative proteomics approach. We found that both groups, and individuals within the groups, could be distinguished from each other and normals based on their specific CSF proteins (p<0.01). CFS (n = 43) had 2,783 non-redundant proteins, nPTLS (n = 25) contained 2,768 proteins, and healthy normals had 2,630 proteins. Preliminary pathway analysis demonstrated that the data could be useful for hypothesis generation on the pathogenetic mechanisms underlying these two related syndromes. Conclusions nPTLS and CFS have distinguishing CSF protein complements. Each condition has a number of CSF proteins that can be useful in providing candidates for future validation studies and insights on the respective mechanisms of pathogenesis. Distinguishing nPTLS and CFS permits more focused study of each condition, and can lead to novel diagnostics and therapeutic interventions.
Evolution of hindlimb bone dimensions and muscle masses in house mice selectively bred for high voluntary wheel‐running behavior

We have used selective breeding with house mice to study coadaptation of morphology and physiology with the evolution of high daily levels of voluntary exercise. Here, we compared hindlimb bones and muscle masses from the 11th generation of four replicate High Runner (HR) lines of house mice bred for high levels of voluntary wheel running with four non‐selected control (C) lines. Mass, length, diameter, and depth of the femur, tibia‐fibula, and metatarsal bones, as well as masses of gastrocnemius and quadriceps muscles, were compared by analysis of covariance with body mass or body length as the covariate. Mice from HR lines had relatively wider distal femora and deeper proximal tibiae, suggesting larger knee surface areas, and larger femoral heads. Sex differences in bone dimensions were also evident, with males having thicker and shorter hindlimb bones when compared with females. Several interactions between sex, linetype, and/or body mass were observed, and analyses split by sex revealed several cases of sex‐specific responses to selection. A subset of the HR mice in two of the four HR lines expressed the mini‐muscle phenotype, characterized mainly by an ∼50% reduction in hindlimb muscle mass, caused by a Mendelian recessive mutation, and known to have been under positive selection in the HR lines. Mini‐muscle individuals had elongated distal elements, lighter and thinner hindlimb bones, altered 3rd trochanter muscle insertion positions, and thicker tibia‐fibula distal widths. Finally, several differences in levels of directional or fluctuating asymmetry in bone dimensions were observed between HR and C, mini‐ and normal‐muscled mice, and the sexes. This study demonstrates that skeletal dimensions and muscle masses can evolve rapidly in response to directional selection on locomotor behavior.
Phosphorylation regulates the Star-PAP-PIPKIα interaction and directs specificity toward mRNA targets

Star-PAP is a nuclear non-canonical poly(A) polymerase (PAP) that shows specificity toward mRNA targets. Star-PAP activity is stimulated by lipid messenger phosphatidyl inositol 4,5 bisphoshate (PI4,5P2) and is regulated by the associated Type I phosphatidylinositol-4-phosphate 5-kinase that synthesizes PI4,5P2 as well as protein kinases. These associated kinases act as coactivators of Star-PAP that regulates its activity and specificity toward mRNAs, yet the mechanism of control of these interactions are not defined. We identified a phosphorylated residue (serine 6, S6) on Star-PAP in the zinc finger region, the domain required for PIPKIα interaction. We show that S6 is phosphorylated by CKIα within the nucleus which is required for Star-PAP nuclear retention and interaction with PIPKIα. Unlike the CKIα mediated phosphorylation at the catalytic domain, Star-PAP S6 phosphorylation is insensitive to oxidative stress suggesting a signal mediated regulation of CKIα activity. S6 phosphorylation together with coactivator PIPKIα controlled select subset of Star-PAP target messages by regulating Star-PAP-mRNA association. Our results establish a novel role for phosphorylation in determining Star-PAP target mRNA specificity and regulation of 3′-end processing.
Doxorubicin Has Dose-Dependent Toxicity on Mouse Ovarian Follicle Development, Hormone Secretion, and Oocyte Maturation

Doxorubicin (DOX), one of the most commonly used anticancer medications, has been reported to affect fertility by damaging ovarian follicles; however, the dose-dependent toxicity of DOX on the dynamic follicle development and oocyte maturation has not been well-defined. Our objective is to determine the effects of human-relevant exposure levels of DOX on follicular functions across developmental time. In vitro cultured multilayered secondary mouse follicles were treated with DOX at 0, 2, 20, 100, and 200 nM for 24 h, and follicle development, hormone secretion, and oocyte maturation were analyzed. DOX caused dose-dependent toxicity on follicle growth, survival, and secretion of 17β-estradiol (E2). At 200 nM, DOX induced DNA damage and apoptosis in follicle somatic cells first and then in oocytes, which was correlated with the uptake of DOX first to the somatic cells followed by germ cells. Follicles treated with DOX at 0, 2, and 20 nM showed similar oocyte metaphase II (MII) percentages after in vitro oocyte maturation; however, 20 nM DOX significantly increased the number of MII oocytes with abnormal spindle morphology and chromosome misalignment. In an effort to harmonize the in vitro study to in vivo treatment, dose-dependent toxicity on oocyte meiotic maturation was found in 16-day-old CD-1 mice treated with DOX at 0, 0.4, 2, and 10 mg/kg, consistent with the in vitro oocyte maturation outcomes. Our study demonstrates that DOX has dose-dependent toxicity on ovarian follicle development, hormone secretion, and oocyte maturation, which are three key factors to support the female reproductive and endocrine functions.
Effects of dietary and exercise intervention on weight loss and body composition in obese postmenopausal women: a systematic review and meta-analysis

Objective: This study examined the effects of dietary and exercise interventions on weight loss and body composition in overweight/obese peri- and postmenopausal women. Methods: Medline, Central, Embase, and Google Scholar databases were searched for relevant trials conducted until December 31, 2016. Randomized controlled trials (RCTs) and prospective studies of overweight/obese peri- or postmenopausal women that examined the effects of dietary or exercise interventions, alone or combined, on weight loss were included. The primary outcome was percentage reduction in body weight. Results: From 292 studies initially identified, 11 studies with 12 sets of participants were included. Both dietary and exercise intervention groups had significantly greater weight loss than control groups (diet vs control: difference in means = −6.55, 95% CI, −9.51 to −3.59, P < 0.001; exercise vs control: difference in means = −3.49, 95% CI, −6.96 to −0.02, P = 0.049). Combined dietary and exercise interventions resulted in greater weight loss than dietary interventions alone (diet plus exercise vs diet: difference in means = −1.22, 95% CI, −2.14 to −0.29, P = 0.010). Diet plus exercise resulted in greater fat loss (difference in means = −0.44, 95% CI, −0.67 to −0.20, P < 0.001) and greater lean mass loss (difference in means = −0.84, 95% CI, −1.13 to −0.55, P < 0.001) than diet alone. Conclusions: Dietary interventions reduced body weight and body composition profile parameters in peri- and postmenopausal women more than exercise alone. The addition of exercise reinforced the effect of dietary interventions on changing body weight and composition.
Building multidisciplinary research

In his poetry, Walt Whitman sings, “I am large, I contain multitudes. ” Most healthy organisms are made up of a multitude of cells and cell types, but none of these cells acts alone. Likewise a cell in homeostasis contains many organelles, but none of these organelles work on their own. How these diverse cells and how these different organelles communicate with each other in time and space are scientific questions that intrigue me. At the same time, like these cooperating cells and organelles, my research is constantly reshaped and transformed by interacting with different people, from my encouraging mentors, energetic trainees, and inspiring colleagues. These personal collaborations motivate and advance my research toward understanding cellular communications that promote metabolic health and organism longevity.
Risk Factors and Time to Recurrent Ipsilateral and Contralateral Patellar Dislocations

Background: Previous studies have reported variable rates of recurrent lateral patellar instability mainly because of limited cohort sizes. In addition, there is currently a lack of information on contralateral patellar instability. Purpose: To evaluate the rate of recurrent ipsilateral patellar dislocations and contralateral patellar dislocations after a first-time lateral patellar dislocation. Additionally, risk factors associated with recurrent dislocations (ipsilateral or contralateral) and time to recurrence were investigated. Study Design: Cohort study; Level of evidence, 3. Methods: This population-based study included 584 patients with a first-time lateral patellar dislocation occurring between 1990 and 2010. A retrospective review was conducted to gather information about the injury, subsequent dislocations (ipsilateral or contralateral), and structural characteristics including trochlear dysplasia, patella alta, and tibial tubercle to trochlear groove (TT-TG) distance. Risk factors were assessed to delineate associations with subsequent dislocations and time to recurrence. Results: At a mean follow-up of 12.4 years, 173 patients had ipsilateral recurrence, and 25 patients had a subsequent contralateral dislocation. At 20 years, the cumulative incidence of ipsilateral recurrence was 36.0%, while the cumulative incidence of contralateral dislocations was 5.4%. Trochlear dysplasia (odds ratio [OR], 18.1), patella alta (OR, 10.4), age <18 years at the time of the first dislocation (OR, 2.4), elevated TT-TG distance (OR, 2.1), and female sex (OR, 1.5) were associated with recurrent ipsilateral dislocations. Time to recurrence was significantly decreased in patients with trochlear dysplasia (23.0 months earlier time to recurrence; P < .001), elevated TT-TG distance (18.5 months; P < .001), patella alta (16.4 months; P = .001), and age <18 years at the time of the first dislocation (15.4 months; P < .001). Risk factors for subsequent contralateral dislocations included patella alta and trochlear dysplasia. Conclusion: At 20 years after a first-time lateral patellar dislocation, the cumulative incidence of recurrent ipsilateral patellar dislocations was 36.0%, compared with 5.4% for contralateral dislocations. Trochlear dysplasia, elevated TT-TG distance, patella alta, age <18 years at the time of the first dislocation, and female sex were associated with ipsilateral recurrence. Trochlear dysplasia, elevated TT-TG distance, patella alta, and age <18 years at the time of the first dislocation were predictive of a statistically significant decrease in time to recurrence.
Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa

ABSTRACT When overproduced, the multidrug efflux system MexEF-OprN increases the resistance of Pseudomonas aeruginosa to fluoroquinolones, chloramphenicol, and trimethoprim. In this work, we demonstrate that gain-of-function mutations in the regulatory gene mexT result in oligomerization of the LysR regulator MexT, constitutive upregulation of the efflux pump, and increased resistance in clinical isolates.
Modeling, analysis and experiments of inter yarn compaction effects in braided composite actuators

Braided composite actuators are pressure-driven muscle-like actuators capable of large displacements as well as large blocking forces. Braided composite actuators can also exhibit a large change in effective stiffness through simple valve control when the working fluid has a high bulk modulus. This is due to the stiff fiber reinforcement of the braided sleeve and the high bulk modulus of the fluid resisting the volume change when a load is applied in the closed-valve condition. Several analytical models have been previously developed that capture the geometrical and material nonlinearities of the composite actuator, the compliance of the inner liner, and entrapped air in the fluid. This article focuses on inter yarn compaction in the fiber sleeve, which is shown to reduce the effective closed-valve stiffness. In this article, a new analytical model that considers inter fiber yarn compaction, fiber extension and entrapped air effect as well as the material and geometric nonlinearities is developed. Analysis and experimental results demonstrate that the new compaction model can improve the prediction of the response behavior of the actuator.
Perception and Iconic Memory : What Sperling

Philosophers have lately seized upon Sperling’s partial report technique and subsequent work on iconic memory in support of controversial claims about perceptual experience, in particular that phenomenology overflows cognitive access. Drawing on mounting evidence concerning postdictive perception, I offer an interpretation of Sperling’s data in terms of cue-sensitive experience which fails to support any such claims. Arguments for overflow based on change-detection paradigms (e.g. Landman et al., 2003; Sligte et al., 2008) cannot be blocked in this way. However, such paradigms are fundamentally different from Sperling’s and, for rather different reasons, equally fail to establish controversial claims about perceptual experience.
Cognitive Control Reflects Context Monitoring, Not Motoric Stopping, in Response Inhibition

The inhibition of unwanted behaviors is considered an effortful and controlled ability. However, inhibition also requires the detection of contexts indicating that old behaviors may be inappropriate – in other words, inhibition requires the ability to monitor context in the service of goals, which we refer to as context-monitoring. Using behavioral, neuroimaging, electrophysiological and computational approaches, we tested whether motoric stopping per se is the cognitively-controlled process supporting response inhibition, or whether context-monitoring may fill this role. Our results demonstrate that inhibition does not require control mechanisms beyond those involved in context-monitoring, and that such control mechanisms are the same regardless of stopping demands. These results challenge dominant accounts of inhibitory control, which posit that motoric stopping is the cognitively-controlled process of response inhibition, and clarify emerging debates on the frontal substrates of response inhibition by replacing the centrality of controlled mechanisms for motoric stopping with context-monitoring.
Climate warming in winter affects the coupling between phytoplankton and bacteria during the spring bloom : a mesocosm study

The response of the phytoplankton and bacterial spring succession to the predicted warming of sea surface temperature in temperate climate zones during winter was studied using an indoor-mesocosm approach. The mesocosms were filled with winter water from the Kiel Fjord, Baltic Sea. Two of them were started at ~2°C and the temperature was subsequently increased according to the decadal temperature profile of the fjord (ΔT 0°C, baseline treatment). The other mesocosms were run at 3 elevated temperatures with differences of ΔT +2, +4 and +6°C. All mesocosms were exposed to the same light conditions. Timing of peak phytoplankton primary production (PP) during the experimental spring bloom was not significantly influenced by increasing temperatures, whereas the peak of bacterial secondary production (BSP) was accelerated by about 2 d per °C. This suggests that, in case of warming, the spring peak of bacterial degradation of organic matter (in terms of BSP) would occur earlier in the year. Furthermore, the lag time between the peaks of PP and BSP (about 16 d for ΔT 0°C) would diminish progressively at elevated temperatures. The average ratio between BSP and PP increased significantly from 0.37 in the coldest mesocosms to 0.63 in the warmest ones. Community respiration and the contribution of picoplankton (<3 µm fraction) to this also increased at elevated temperatures. Our results lead to the prediction that climate warming during the winter/ early spring in temperate climate zones will favor bacterial degradation of organic matter by tightening the coupling between phytoplankton and bacteria. However, if PP is reduced by warming, as in our experiments, this will not necessarily lead to increased recycling of organic matter (and CO2).
A 65nm CMOS fraction-N digital PLL with shaped in-band phase noise

A digital phase-locked loop (DPLL) which uses a high resolution 2-dimension gated-Vernier time-to-digital converter (TDC) is presented. The shaped Vernier quantization of TDC greatly improves the in-band phase noise. Also the 2-dimension structure makes DPLL be able to process large phase errors almost without the influence of latency time. Combined with a high figure-of-merit (FOM) class-D digitally controlled oscillator (DCO), the DPLL achieves -110dBc/Hz and -130dBc/Hz for in-band and 1MHz-offset phase noise, respectively, with carrier frequency of 3.5 GHz. The digital PLL is simulated in a 65nm CMOS process, consuming 11.2mW from a 1.0V supply.
Invisible Mask: Practical Attacks on Face Recognition with Infrared

Accurate face recognition techniques make a series of critical applications possible: policemen could employ it to retrieve criminals' faces from surveillance video streams; cross boarder travelers could pass a face authentication inspection line without the involvement of officers. Nonetheless, when public security heavily relies on such intelligent systems, the designers should deliberately consider the emerging attacks aiming at misleading those systems employing face recognition. We propose a kind of brand new attack against face recognition systems, which is realized by illuminating the subject using infrared according to the adversarial examples worked out by our algorithm, thus face recognition systems can be bypassed or misled while simultaneously the infrared perturbations cannot be observed by raw eyes. Through launching this kind of attack, an attacker not only can dodge surveillance cameras. More importantly, he can impersonate his target victim and pass the face authentication system, if only the victim's photo is acquired by the attacker. Again, the attack is totally unobservable by nearby people, because not only the light is invisible, but also the device we made to launch the attack is small enough. According to our study on a large dataset, attackers have a very high success rate with a over 70\% success rate for finding such an adversarial example that can be implemented by infrared. To the best of our knowledge, our work is the first one to shed light on the severity of threat resulted from infrared adversarial examples against face recognition.