Miracle-dz/UniFAR-FTUs huggingface dataset:
The camKK2/camKIV relay is an essential regulator of hepatic cancer

Hepatic cancer is one of the most lethal cancers worldwide. Here, we report that the expression of Ca2+/calmodulin‐dependent protein kinase kinase 2 (CaMKK2) is significantly up‐regulated in hepatocellular carcinoma (HCC) and negatively correlated with HCC patient survival. The CaMKK2 protein is highly expressed in all eight hepatic cancer cell lines evaluated and is markedly up‐regulated relative to normal primary hepatocytes. Loss of CaMKK2 function is sufficient to inhibit liver cancer cell growth, and the growth defect resulting from loss of CaMKK2 can be rescued by ectopic expression of wild‐type CaMKK2 but not by kinase‐inactive mutants. Cellular ablation of CaMKK2 using RNA interference yields a gene signature that correlates with improvement in HCC patient survival, and ablation or pharmacological inhibition of CaMKK2 with STO‐609 impairs tumorigenicity of liver cancer cells in vivo. Moreover, CaMKK2 expression is up‐regulated in a time‐dependent manner in a carcinogen‐induced HCC mouse model, and STO‐609 treatment regresses hepatic tumor burden in this model. Mechanistically, CaMKK2 signals through Ca2+/calmodulin‐dependent protein kinase 4 (CaMKIV) to control liver cancer cell growth. Further analysis revealed that CaMKK2 serves as a scaffold to assemble CaMKIV with key components of the mammalian target of rapamycin/ribosomal protein S6 kinase, 70 kDa, pathway and thereby stimulate protein synthesis through protein phosphorylation. Conclusion: The CaMKK2/CaMKIV relay is an upstream regulator of the oncogenic mammalian target of rapamycin/ribosomal protein S6 kinase, 70 kDa, pathway, and the importance of this CaMKK2/CaMKIV axis in HCC growth is confirmed by the potent growth inhibitory effects of genetically or pharmacologically decreasing CaMKK2 activity; collectively, these findings suggest that CaMKK2 and CaMKIV may represent potential targets for hepatic cancer. (Hepatology 2015;62:505–520
Implementation of the FISH! Philosophy in Primary Care: A change in the culture of healthcare delivery

"Background: Public Health Departments often serve a disenfranchised patient population. While practitioners are committed to providing exceptional care to vulnerable populations, lack of resources and governmental bureaucracy often result in provider and staff fatigue that can translate to high attrition rates. Supporting staff may not share the institutional vision of being viewed as a leading resource for community healthcare services. Problem: The clinical atmosphere was dull and bleak. It lacked, light, color, and energy. Staff morale was generally low and patient satisfaction scores were suboptimal. The purpose of this project was to transform the culture of healthcare delivery. The clinical question was: Will a new philosophy of conducting daily work enhance staff fulfillment and improve retention? Can noticeable improvements be realized in patient satisfaction scores through enhancements in organizational culture? Methodology: The FISH! Philosophy was implemented to structure cultural improvement. Four key aspects of this philosophy are: 1. ) Play â€“ encourage creativity and enjoyment at work; 2. ) Make their day â€“ an effort to enhance the lives of patients and colleagues regularly; 3. ) Be there â€“ embrace the moment and be fully engaged; 4. ) Choose your attitude â€“ there is a choice in the way we approach our daily work and lives. Energetic employees translate to satisfied patients and organizational success. Evaluation: A comparison of pre and post employee surveys were utilized to appraise the strategic efficacy of the FISH! Philosophy. These demonstrated an overall improvement in the final evaluation of enjoyment of the work culture, feeling appreciated, and a shift in work perception to determine success of the quality improvement initiative. Staff retention further illustrated improvement. The current tool utilized to measure patient satisfaction was deployed to assess change. Enhancements were noted in the patient satisfaction survey for the quarter during this quality improvement initiative compared to the previous two reporting years for the same quarter and year-end results. "
DNA-mediated transfer of a human gene required for low-density lipoprotein receptor expression and for multiple Golgi processing pathways

Transfection of a hamster cell mutant with human DNA corrected both the low-density lipoprotein receptor-deficient phenotype and the multiple glycosylation defects of the cells. Independently transfected colonies contained a small set of common human DNA fragments. These fragments may correspond to the human analog of a single gene required for several different Golgi processing pathways.
GEOTHERMOBAROMETRY OF GRANULITES OF THE JUIZ DE FORA COMPLEX AND THE ANDRELÂNDIA GROUP IN THE REGION OF ABRE CAMPO AND MANHUAÇU, MINAS GERAIS, BRAZIL

Mafic and felsic ortho-derived granulites of the Juiz de Fora Complex and para-derived aluminous granulites of the Andrelândia Group occur in the Abre Campo and Manhuacu regions, state of Minas Gerais. The ortho- and para-derived rocks are tectonic intercalated as result of the edification of the neoproterozoic Aracuai Orogen. The mafic granulites are formed by the mineral assemblage of plagioclase + orthopyroxene + clinopyroxene ± hornblende. The felsic granulites are composed of plagioclase + quartz + potassium feldspar ± orthopyroxene ± garnet. The mineral assemblage of the aluminous granulites is plagioclase + quartz + garnet + biotite ± potassium feldspar ± sillimanite. Calculations using conventional geothermobarometry and the THERMOCALC software resulted in temperatures between 748 °C and 870 °C and pressures between 5.7 kbar and 7.5 kbar for the granulite facies metamorphism related to the development of the Aracuai Orogen. The local presence of a mylonitic foliation as well as of intensily deformed porphyroclasts is associated to the reactivation of shear zones as those of Manhuacu and Abre Campo during southward escape of orogen. This stage is characterized for development of large dextral shear zones. The exhumation of granulites of Juiz de Fora Complex and Andrelandia Group are related to the gravitational collapse of the Aracuai Orogen.
NimbRo TeenSize 2011 Team Description

This document describes the RoboCup Humanoid League team NimbRo TeenSize of Rheinische Friedrich-Wilhelms-Universität Bonn, Germany, as required by the qualification procedure for the competition to be held in Istanbul in July 2011. Our team uses self-constructed robots for playing soccer. The paper describes the mechanical and electrical design of the robots. It also covers the software used for perception and behavior control.
Leveraging Sentiment Analysis to predict Ratings of Reviews

Online reviews are an important asset for users deciding to buy a product, see a movie, or go to a restaurant, as well as for managers making business decisions. The reviews in the e-commerce websites are usually accompanied by ratings, facilitating users to learn the reviews. However, a lot of reviews spread across forums or social media are written in a plain text, which do not have ratings, called non-rated review in this paper. From the perspective of sentiment analysis, this study develops a predictive framework to calculate the ratings for non-rated reviews. The idea behind the framework begins at a couple of observations: (1) the rating of the review depends on sentiment score of aspects as well as the number of positive and negative aspects in the review; (2) the sentiment score of an aspect is determined by its context. Viewing term-pairs co-occurring with aspects as their context, we conceive of a variant of Conditional Random Field model, called SentiCRF, for generating term-pairs and calculating their sentiment scores from a train set. Then we develop a cumulative logit model that uses aspects and their sentiments in a review to predict ratings of the review. In addition, we meet a challenge of class imbalance on calculating sentiment scores of term-pairs. We also propose a heuristic re-sampling method to tackle class imbalance. Experiments conducted on the YELP dataset demonstrate the predictive framework is feasible and effective on predicting rating of reviews.
Challenges for the Development of Ribonucleoside Analogues as Inducers of Error Catastrophe

RNA viruses are responsible for numerous human diseases; some of these viruses are also potential agents of bioterrorism. In general, the replication of RNA viruses results in the incorporation of at least one mutation per round of replication, leading to a heterogeneous population, termed a qua-sispecies. The antiviral nucleoside ribavirin has been shown to cause an increase in the mutation frequency of RNA viruses. This increase in mutation frequency leads to a loss of viability due to error catastrophe. In this article, we review lethal mutagenesis as an antiviral strategy, emphasizing the challenges remaining for the development of lethal mutagenesis into a practical clinical approach.
Volatility and Market Integration of Spot-Forward Corn Price in Indonesia

This study aims to determine the volatility and market integration between the price of corn in the Indonesian spot market and futures market in the international market. The data used in this research is secondary data consisting of Indonesian corn spot price and corn forward price referring commodity exchange, Chicago. Data in the form of monthly time series in 2007 until 2016. ARCH / GARCH method is used to measure the volatility at spot and forward price, whereas the market integration of spot and forward corn is used Johansen Cointegration and Engel-Granger Causality method. The results show that spot and forward prices of corn occur high volatility. The best ARCH/GARCH model for spot price is GARCH (2,0) with the volatility value of 0,91 and for forward price is GARCH (2,0) with the volatility value of 1.12. It means that volatility of spot and forward influenced by the increase and fluctuations of spot and forward price two previous periods. Between the spot and forward market, there is market integration and a one-way causal relationship. The market integration indicates there is long-run relationship, while one way indicates the spot price effect on the forward price, not vice versa.
Formulation and Analysis of a Parameter-Free Stabilized Finite Element Method

We present and study a parameter-free stabilized finite element method for the scalar advection-diffusion equation. Edge element lifting of diffusive edge fluxes defines the stabilization. The amount of edge diffusion varies with the edge Peclet number and adapts to solution features without mesh-dependent parameters. We prove that the method is first-order accurate in the advective limit. Numerical studies confirm the theoretical estimates.
Unsupervised Feature Selection with Structured Graph Optimization

Since amounts of unlabelled and high-dimensional data needed to be processed, unsupervised feature selection has become an important and challenging problem in machine learning. Conventional embedded unsupervised methods always need to construct the similarity matrix, which makes the selected features highly depend on the learned structure. However real world data always contain lots of noise samples and features that make the similarity matrix obtained by original data can't be fully relied. We propose an unsupervised feature selection approach which performs feature selection and local structure learning simultaneously, the similarity matrix thus can be determined adaptively. Moreover, we constrain the similarity matrix to make it contain more accurate information of data structure, thus the proposed approach can select more valuable features. An efficient and simple algorithm is derived to optimize the problem. Experiments on various benchmark data sets, including handwritten digit data, face image data and biomedical data, validate the effectiveness of the proposed approach.
Johnson ’ s Formula for Predicting Birth Weight in Pregnant Mothers at Jimma University Teaching Hospital , South West Ethiopia

Fetal weight is a very important factor based on which decision must be made concerning labor and delivery. The prevalence of obstructed labour at JUSH, our study area, is 12.2 % [1-5]. Neonatal morbidities associated with obstructed labour are cerebral edema, neurological damage, hypoxia and asphyxia during or after the delivery. LBW or VLBW foetuses, fetal death, birth asphyxia, meconium aspiration, neonatal hypoglycaemia. To prevent or treat the fetal, neonatal and maternal morbidities and mortalities associated with LBW and macrosomic neonates, accurate estimation of fetal weight is very important.
A study of the reliability of the Canada Fitness Survey questionnaire.

PURPOSE The purposes of this study are to assess the reliability of the physical activity components of the Canada Fitness Survey (CFS) questionnaire (N = 64 males, N = 63 females) and the Canadian Aerobic Fitness Test (N = 44 males, N = 52 females) in a sample of subjects between 15 and 80 yr. RESULTS The intraclass correlation (rI) for the fitness scores was 0.98. The activity variables showed low to moderate correlations (rI = 0.48-0.53). Correlations were higher for males (rI = 0.38-0.65) than females (rI = 0.28-0.60) for most of the activity variables reported. Males generally report leisure activity more reliably than nonleisure activity, whereas the opposite was true for females. Males reported strenuous activity with higher reliability (rI = 0.86) than females (rI = 0.31). There was considerable variation in the reliability of specific activities. Of the components of physical activity (time, intensity, duration) that comprise the energy expenditure (EE) variable, the least reliably reported is intensity for both males (rI = 0.43) and females (rI = 0.55). CONCLUSIONS The CFS questionnaire is moderately reliable for most measures of physical activity. Estimates of reliability vary considerably among the various activities and components of these activities and between males and females.
Characterization of Spatial Repellent, Contact Irritant, and Toxicant Chemical Actions of Standard Vector Control Compounds1

Abstract A previously described modular high-throughput screening system was used to characterize the spatial repellent, contact irritant, and toxicant chemical actions of 14 compounds historically used or under investigation for vector control. The response of F1–F4 Aedes aegypti (Thailand strain) to various concentrations of 4 organochlorines (chlordane, DDT, dieldrin, methoxychlor); 4 pyrethroids (alphacypermethrin, cypermethrin, deltamethrin, permethrin); 3 organophosphates (chlorpyrophos methyl, fenitrothion, malathion); 2 carbamates (bendiocarb, propoxur); and 1 pyrazole (chlorfenapyr) were evaluated. Results show chemicals exert different combinations of contact irritant, spatial repellent, and toxic actions. This is true even within the same chemical class. These actions can be ordered for each chemical based on the testing dose at which the specific response is elicited. Data also indicate that behavioral responses to spatial repellent and contact irritant actions are separate (or independent) from the toxic action of a compound. Results from pyrethroid and DDT assays also show chemicals can induce behavior-modifying actions, such as contact irritancy and spatial repellency, which will reduce man-vector contact, despite evidence of insecticide resistance within the test population. These findings support previous laboratory and field studies showing man-vector contact and disease transmission are routinely interrupted by spatial repellent and contact irritant actions of common public health insecticides. Studies similar to that presented here can be used as baseline evidence for expected vector responses and support best approaches for more detailed behavioral research.
WordnetLoom – a Multilingual Wordnet Editing System Focused on Graph-based Presentation

The paper presents a new re-built and expanded, version 2.0 of WordnetLoom – an open wordnet editor. It facilitates work on a multilingual system of wordnets, is based on efficient software architecture of thin client, and offers more flexibility in enriching wordnet representation. This new version is built on the experience collected during the use of the previous one for more than 10 years of plWordNet development. We discuss its extensions motivated by the collected experience. A special focus is given to the development of a variant for the needs of MultiWordnet of Portuguese, which is based on a very different wordnet development model.
Wool-A work stealing library

This paper presents some preliminary results on a small light weight user level task management library called Wool. The Wool task scheduler is based on work stealing. The objective of the library is to provide a reasonably convenient programming interface (in particular by not forcing the programmer to write in continuation passing style) in ordinary C while still having a very low task creation overhead. Several task scheduling systems based on work stealing exists, but they are typically either programming languages like Cilk-5 or based on C++ like the Intel TBB or C# as in the Microsoft TPL. Our main conclusions are that such a direct style interface is indeed possible and yields performance that is comparable to that of the Intel TBB.
Isolation and Characterization of Endoglucanases 1 and 2 from Bacteroides succinogenes S 85

Two endoglucanases designated EG1 and EG2 were purified by column chromatography from the nonsedimentable extracellular culture fluid of Bacteroides succinogenes S85. They accounted for approximately 32 and 11%, respectively, of the total endoglucanase present in the nonsedimentable fraction. The most active enzyme (EG1) had a molecular weight of 65,000, pl of 4.8, and temperature and pH optima of 39°C and 6.4, respectively. The Km for carboxymethyl cellulose was 3.6 mg/ml, and the V. , was 84 U/mg. The major products of cellulose hydrolysis catalyzed by EG1 were cellotriose and cellobiose. EG2 was present as two components with molecular weights of 118,000 and 94,000. The two components had nearly identical cyanogen bromide peptide maps, thereby indicating that the 94,000-dalton component was a proteolytic degradation product of the 118,000-dalton enzyme. The larger component, which was more abundant in the culture fluid than the smaller form was, had a Km of 12.2 mg/ml and a V.x of 10.4 U/mg. It was a basic protein with a, pl of 9.4, a temperature optimum of 39°C, and a pH optimum of 5.8. The major product of cellulose hydrolysis was cellotetraose. EG2 exhibited specific binding to acid-swollen cellulose, whereas EG1 did not, and neither of them had affinity for crystalline cellulose. Based on the substrate specificities and the affinities of the two enzymes for cellulose, we postulated that EG2 is involved in the early stages of cellulose hydrolysis and that EG1 is active primarily on the products arising from EG2.
Application of a new variational functional for electron-molecule collisions: an extension of the Schwinger variational principle

Discusses a variational functional for scattering theory which has been recently proposed by Takatsuka and McKoy (1980). It is shown that this functional can provide results with a purely discrete set of functions which are approximately equivalent to those obtained by Lucchese et al. (1980) from the first iteration of the iterative Schwinger method. Applications to the scattering of electrons by systems including CO+ and LiH illustrate this relationship and other features of the method.
A modified double-emulsion method for the preparation of daunorubicin-loaded polymeric nanoparticle with enhanced in vitro anti-tumor activity

The encapsulation of hydrophilic drug in polymeric nanoparticles with high loading remains a challenge due to the rapid penetration of the drug to the external aqueous phase. In order to improve the encapsulation efficiency of daunorubicin (DNR) in poly(d,l-lactic-co-glycolic acid (PLGA) and poly(d,l-lactic acid) (PDLLA) nanoparticles, we fabricated a series of DNR-loaded nanoparticles using a modified double-emulsion solvent evaporation/diffusion method, which introduced a partially water-soluble organic solvent into the particle formation. The influence of various preparation parameters was investigated systematically, such as the ratio of organic solvent, the type of surfactant, the type of polymers and the molecular weight. Results showed that regular spherical PLGA nanoparticles with diameters of 200–300 nm could be produced with a remarkably high DNR encapsulation efficiency (>80%) and loading (6.5% (w/w)). Upon encapsulation, the sustained release of DNR could be controlled over 2 weeks. The results of FT-IR and DSC analysis indicated that the encapsulated DNR in polymeric nanoparticles was inclusion, not absorption. Furthermore, optimized DNR/PLGA nanoparticles showed a significant enhancement of cellular uptake, higher cytotoxicity against HL-60 cells compared with free DNR. These results were potentially useful for the nanoparticle formulation of hydrophilic chemotherapeutic drugs that require efficient delivery to cancer cells as well as sustained release at the specific site.
Barriers and benefits of using social networking sites versus face-to-face meetings for sharing knowledge in professional societies

This study aims to assess the benefits and barriers of social networking sites (SNS) for sharing knowledge in professional societies, compared to face-to-face meetings (F2F). SNS can be a valuable technology for non-profit organisations. Studies have investigated the barriers and benefits of knowledge sharing in firm-based communities of practice (CoP) or virtual CoP, but not much is known about professional societies' use of public SNS for knowledge sharing. Based on two rounds of a Delphi study, the results revealed the benefits and barriers of F2F meetings compared to the benefits and barriers of SNS for sharing knowledge in professional societies.
Cholecystokinin Octapeptide In Vitro and Ex Vivo Strongly Modulates Striatal Dopamine D2 Receptors in Rat Forebrain Sections

Receptor autoradiographic experiments together with the filter wipe‐off technique were performed to investigate the effects of cholecystokinin octapeptide (CCK‐8) on dopamine D2 receptors. In vitro studies showed that 1 nM CCK‐8 significantly increased the KD value of binding sites for the D2 agonist [3H]N‐propylnorapomorphine (NPA) in the rostral and caudal parts of the nucleus accumbens by 48 and 148% respectively. In contrast, 1 nM CCK‐8 significantly decreased the IC50 value of dopamine for binding sites for the D2 antagonist [125I]iodosulpride in the rostral and caudal parts of the caudate‐putamen by 46 and 56% respectively, and in the rostral and caudal parts of the nucleus accumbens (areas of CCK‐dopamine coexistence) by 57 and 75% respectively. Ex vivo studies demonstrated that 30 min after an intraventricular injection of 1 nmol/rat CCK‐8 the KD value of [3H]NPA binding sites in the caudal part of the forebrain and the IC50 value of dopamine for [125I]iodosulpride binding sites in the caudal part of the nucleus accumbens were significantly increased by 160% and decreased by 77% respectively. These results indicate for the first time that in sections CCK‐8 in vitro and ex vivo can strongly regulate D2 receptor affinity in the striatum. The present studies also provide evidence for stronger modulation of D2 receptors by CCK‐8 in the area of CCW‐dopamine coexistence in the nucleus accumbens than in other basal ganglion areas, supporting the existence of CCWD2 receptor interactions in cotransmission. The stronger interactions found in sections than in membrane preparations may indicate the requirement of intracellular mechanisms and/or a more intact membrane structure for optimal receptor‐receptor interactions.