Miracle-dz/UniFAR-FTUs huggingface dataset:
Antithrombin-3 deficiency in a Dutch family.

A Dutch family (family A) with inherited antithrombin-III deficiency and an increased incidence of venous thrombosis was investigated. Antithrombin-III levels were measured by means of a coagulation assay in plasma and by single radial immunodiffusion in plasma and serum.THREE GROUPS COULD BE DISTINGUISHED: group I comprised the relations-in-law of family A, group II the members of family A with a plasma antithrombin-III level higher than 90% of normal, when determined by the immunoassay, and group III the members of family A with an antithrombin-III level of less than 60%. To group III belonged all eight adults with an abnormal tendency to thrombosis, and furthermore nine children, all having a parent with abnormally low antithrombin-III levels. Mean plasma and serum antithrombin-III levels were significantly decreased in group III. However, the results of the coagulation assay showed some overlap between groups II and III. In addition, the immunoassay appeared to be much less laborious than the coagulation assay. Therefore, the former assay is recommended in any search for similar families. The results of our family investigation confirm the findings of Egeberg (1965) that inherited antithrombin-III deficiency, giving rise to plasma levels between 50 and 60% of normal, causes thrombophilia and that the pattern of inheritance is autosomal dominant.
Medical Complications of Surgical Treatment of Adult Spinal Deformity and How to Avoid Them

Study Design. Review article of medical complications related to adult spinal deformity surgery. Objective. To identify medical complications related to surgery for adult spinal deformity and suggest ways to minimize their occurrence and to avoid them. Summary of Background Data. Medical complications are a major consideration in adult spinal deformity surgery. Few studies have been done to identify the medical complication rate in relation to these procedures. Methods. We review the literature pertaining to medical complications regarding spinal deformity surgery. Results. Urinary tract infections are the most frequently seen complication. Additionally, pulmonary complications are the most common life-threatening complication. Medical complications are a frequent occurrence with adult deformity spinal surgery. Conclusions. Awareness of the presentation, treatment, and prevention of medical complications of deformity surgery may allow minimization of their occurrence and optimize treatment should they occur.
From acoustic simulation to virtual auditory displays

Simulation and auralization techniques are used in engineering, architecture, sound design and in applications in hearing research. The components of this technique are acoustic simulations and signal processing tools and the data interfaces in between, for which well-established solutions exist. The main bottlenecks are lack of data of 3D characterization of sound sources and material parameters, and interfaces to spatial audio technology. These problems are subject to research. Whether the virtual environment is considered sufficiently accurate or not, depends on many perceptual factors, and on the pre-conditioning and the degree of immersion of the user in the virtual environment. In this presentation the processing steps for creation of Virtual Acoustic Environments are briefly presented and illustrated in examples including room acoustics, music, history, and hearing research.
Low-Power Selective Control of Ultrafast Vortex-Core Switching by Circularly Rotating Magnetic Fields: Circular–Rotational Eigenmodes

We found novel dynamic properties of vortex gyrotropic motions in soft magnetic nanodots driven by oscillating in-plane magnetic fields. The elementary eigenmodes of the field-driven gyrotropic motions are found to be the two counterclockwise (CCW) and clockwise (CW) circularly rotating motions of a vortex core (VC) with respect to the corresponding CCW and CW circularly rotating fields (H CCW and H CW) of a certain angular frequency omegaH. Owing to asymmetric resonance characteristics between the two orthogonal eigenmodes at omegaH close to the vortex eigenfrequency omegaD , the use of H CCW (H CW) with omegaH ~ omegaD allows us to selectively and reliably switch, with sufficiently low field strengths as small as ~ 10 Oe, only the upward (downward) oriented VC to its downward (upward) one. The results promise a reliable, low-power, and effective means of information storage, recording, and readout, representing an advanced step toward realizing a new class of vortex-based random access memory (VRAM) devices.
Complete Genome Sequence of a Hemagglutination-Negative Avian Paramyxovirus Type 4 Isolated from China

ABSTRACT We report here the complete genome sequence of a nonpathogenic and hemagglutination-negative avian paramyxovirus type 4 isolated from a duck in southern China. Phylogenetic analysis of the genome sequence indicated that the waterfowl virus possibly has evolved into the Eastern and Western Hemisphere lineages.
Disease-causing mutations in the serpin antithrombin reveal a key domain critical for inhibiting protease activities

Antithrombin mainly inhibits factor Xa and thrombin. The reactive center loop (RCL) is crucial for its interactions with its protease targets and is fully inserted into the A-sheet after its cleavage, causing translocation of the covalently linked protease to the opposite end of the A-sheet. Antithrombin variants with altered RCL hinge residues behave as substrates rather than inhibitors, resulting in stoichiometries of inhibition greater than one. Other antithrombin residues have been suggested to interfere with RCL insertion or the stability of the antithrombin–protease complex, but available crystal structures or mutagenesis studies have failed to identify such residues. Here, we characterized two mutations, S365L and I207T, present in individuals with type II antithrombin deficiency and identified a new antithrombin functional domain. S365L did not form stable complexes with thrombin or factor Xa, and the I207T/I207A variants inhibited both proteases with elevated stoichiometries of inhibition. Close proximity of Ile-207 and Ser-365 to the inserted RCL suggested that the preferred reaction of these mutants as protease substrates reflects an effect on the rate of the RCL insertion and protease translocation. However, both residues lie within the final docking site for the protease in the antithrombin–protease complex, supporting the idea that the enhanced substrate reactions may result from an increased dissociation of the final complexes. Our findings demonstrate that the distal end of the antithrombin A-sheet is crucial for the last steps of protease inhibition either by affecting the rate of RCL insertion or through critical interactions with proteases at the end of the A-sheet.
Propuesta de un modelo de análisis redinformétrico multinivel para el estudio sistémico de las universidades españolas (2010)

La universidad, en tanto que institucion milenaria, tiene una influencia y peso en la sociedad actual incuestionable. Una influencia tanto activa (en su vertiente formadora de futuros profesionales y ciudadanos, y de generacion de nuevo conocimiento e investigacion) como pasiva (debido a sus enormes necesidades de financiacion). Este peso e influencia de las universidades en la sociedad marcan la necesidad de establecer mecanismos y procedimientos para analizar su rendimiento, eficiencia y eficacia como institucion, asi como de instrumentos para visualizar adecuadamente este rendimiento, todo ello en el contexto de una sociedad marcada por la gestion y transferencia masiva de informacion a traves de las redes de comunicacion. Se vislumbran por tanto 3 lineas de investigacion complementarias: el analisis de la universidad, su rendimiento (explicitado por el rastro digital que esta genera y las tecnicas existentes para cuantificarlo), y la visualizacion de este rendimiento, donde la tecnica de ranking es la mas extendida dado el impacto que su formato genera en los usuarios. Ademas, la naturaleza sistemica de la universidad determina, complica y acota cada una de estas areas. La presente tesis doctoral pretende por tanto explorar las capacidades que la cibermetria (renombrada en este trabajo como redinformetria) proporciona para analizar, desde un punto de vista sistemico, las universidades del sistema espanol, con el proposito de obtener nuevo conocimiento acerca del rendimiento de estas que permita la construccion futura de rankings sistemicos de universidades. Para ello, en primer lugar se ofrece un estado de la cuestion enfocado en las 3 principales lineas de trabajo (universidad, ranking y cibermetria), con el objetivo de ofrecer un marco de trabajo exhaustivo y critico. Tras la parte introductoria, se propone un modelo de analisis redinformetrico multinivel de universidades que facilite la obtencion de informacion estructurada, y que permita su posterior utilizacion en el diseno y elaboracion de rankings web de universidades. Este modelo de analisis se basa en el establecimiento de 3 niveles (institucional, externo y satelite) y dos subniveles (contorno e interno). Los resultados obtenidos muestran que el modelo de analisis propuesto, basado en niveles (institucional, externo y satelite) y subniveles (contorno y unidad) es sencillo, independiente de tecnica y proporciona informacion estructurada que permite un analisis completo de cada institucion.
The Digital Classicist: building a Digital Humanities Community

There has been much discussion about digital humanities (DH) both as a discipline and as a community of practice. Whatever the balance of opinion, the emergence of digital scholarship in the humanities has undoubtedly had considerable impact on many disciplines; one such discipline is Classics and the study of the ancient world more generally. This article uses the Digital Classicist (DC) as an example of a DH community in a case study which traces its development and growth to examine what might be learned. As a community the DC joins together practitioners interested in the application of innovative digital methods and technology to the study of the ancient world (in its widest sense). How has this come about and perhaps more importantly, how has it been sustained and indeed provided the inspiration for other affiliated communities? What do we understand by a community and the association of individual practitioners separated by distance? It is important that members feel that they are stakeholders, that they have a sense of ownership and derive value from participation and contribution. It is argued here that a community could be seen as a symbolic and intellectual construct, one of perception rather than physicality to facilitate the exchange of ideas and so effect growth and strengthen the discipline.
The use of noncontingent reinforcement and contingent restraint to reduce physical aggression and self-injurious behaviour in a traumatically brain injured adult.

Many different intervention programmes for reducing undesirable behaviour with people with traumatic brain injury (TBI) have been investigated in recent years. The purpose of this study was to examine the potential of using noncontingent reinforcement (NCR) in combination with contingent restraint to reduce severe behaviour. The subject (E.L.) was a 40-year-old male with TBI admitted to a rehabilitation long-term care programme. E.L. had a history of physical aggression (PA) and self-injurious behaviour (SIB). Assessment conditions included a descriptive analysis, response scatterplot and Self-Injury Trauma (SIT) Scale. Attention was identified as the maintaining positive reinforcement for PA and SIB. Treatment conditions were compared using a reversal (ABAB) design. Attention (NCR) was delivered on a fixed-time schedule that was not dependent on the subject's behaviour. Contingent restraint was applied when E.L. exhibited PA or SIB that was dangerous to himself or others. During treatment, PA occurred over 4 times less often and SIB over 2.5 times less often. Results demonstrated that PA and SIB were sensitive to NCR. NCR can be an effective procedure for reducing severe behaviour maintained by socially-mediated positive reinforcement.
Automated Integration Testing – an Evaluation of CruiseControl

Testing is an important task of the software development process. It gives assurance of many things, for example that the software executes correctly or that its performance is within acceptable limits – it gives assurance of the quality for the software. Despite this fact, testing is the task that often gets down prioritized because of budget constraints or time shortage. Often this depends on the fact that testing must be performed manually and thus becomes a very time consuming task. Automation is something seen as a potential and partial solution to this problem. This report presents the results of using a continuous integration server – CruiseControl.NET – and the NUnit framework, as a means for automating the integration testing in a specially selected project at a Swedish IT-company. It also presents evaluation results regarding the use of CruiseControl.NET as a pure software testing tool. The evaluation was performed in parallel with the work of automating the integration testing. With the approach presented above, the integration testing could be partially automated. However, it was also confirmed that an initial investment is needed to achieve even, only a partial automation of the software testing. Further it was established that CruiseControl.NET has some potential of increasing cost-effectiveness for the integration testing as well as contributing to a higher, final quality of developed software. Automatisk integrationstestning – en utvärdering av CruiseControl.NET Sammanfattning Testning är en viktig del i processen för programvaruutveckling. Den ger försäkran om många saker, till exempel att programvaran exekverar korrekt eller att dess prestanda är inom accepterbara gränser – den ger försäkran om gällande kvalité för programvaran. Trots detta är testningen den del som ofta blir nedprioriterad på grund av budgetbegränsningar eller tidsbrist. Ofta beror detta på att testningen måste utföras manuellt och därför kan bli en mycket tidskrävande uppgift. Automatisering är sett som en potentiell och partiell lösning till detta problem. Denna rapport presenterar resultaten av att använda en ”kontinuerlig integrations”-server – CruiseControl.NET – samt NUnit-ramverket för att automatisera integrationstestningen i ett speciellt utvalt projekt, på ett svenskt IT-företag. Den presenterar också resultat rörande en utvärdering av CruiseControl.NET sedd som ett rent testverktyg. Utvärderingen utfördes parallellt med arbetet att automatisera integrationstestningen. Med tillvägagångssättet presenterat ovan kunde integrationstestningen delvis automatiseras. Emellertid bekräftades också att det krävs en initial investering för att implementera även en, endast delvis automatisering av programvarutestningen. Vidare konstaterades att CruiseControl.NET, till en viss del har potential att öka kostnadseffektiviteten för integrationstestningen så väl som att bidra till en högre, slutlig kvalité på den utvecklade programvaran.
A logic‐based approach to rule induction in expert systems

Rule induction is an important part of learning in expert systems. Rules can help managers make more effective decisions and gain insight into the relationships between decision variables. We present a logic‐based approach to rule induction in expert systems which is simple, robust and consistent. We also derive bounds on levels of certainty for combining rules. We apply our approach to the development of rules for the entry decisions of new products. We then discuss how the logic‐based approach of rule induction can be used to create a decision support system and the methodology to create such a system.
Long-term evaluation of periodontal parameters and implant outcomes in periodontally compromised patients: a systematic review.

BACKGROUND The aim of this systematic review is to evaluate the long-term outcomes of patients with periodontitis submitted to periodontal therapy/maintenance and implant placement. METHODS Studies reporting clinical and/or long-term implant outcomes from partially edentulous patients with periodontitis who were treated and followed periodontal maintenance for ≥5 years were considered eligible for the review. Screening of the articles, data extraction, and quality assessment were conducted independently and in duplicate. RESULTS Search of MEDLINE, EMBASE, and CENTRAL databases resulted in 959 papers, and of them 931 were excluded after title/abstract assessment. The full texts of 28 potentially eligible publications were screened, but only 10 studies met inclusion criteria. Most of the included studies (77.8%) presented a medium/high methodologic quality. The results demonstrated that patients with a diagnosis of periodontitis had satisfactory implant outcomes. Implant survival was high (92.1%) within studies reporting 10 years of follow-up. Parameters related to probing depth, clinical attachment level, and bone loss around teeth increased the occurrence of peri-implantitis and implant loss. Non-attendance to periodontal maintenance and smoking habits were also associated with less favorable implant outcomes. CONCLUSIONS This systematic review confirmed that implant therapy can be successfully used in patients with a diagnosis of periodontitis who underwent proper therapy and regular periodontal maintenance. Residual pockets, non-attendance to the periodontal maintenance program, and smoking were considered to be negative factors for the long-term implant outcomes.
Polarized secretion of CXC chemokines by human intestinal epithelial cells in response to Bacteroides fragilis enterotoxin: NF‐κB plays a major role in the regulation of IL‐8 expression

Enterotoxigenic B. fragilis, which produces a ∼20 kD heat‐labile toxin (BFT), has been associated with diarrhoeal diseases and mucosal inflammation. To determine if epithelial cells can contribute to BFT‐induced inflammation, we assessed the expression of CXC chemokines by BFT‐stimulated human intestinal epithelial cells. BFT stimulation increased expression of the neutrophil chemoattractant and activators ENA‐78, GRO‐α, and IL‐8. Up‐regulated chemokine mRNA expression was paralleled by increased protein levels. Activation of the IL‐8 and NF‐κB transcriptional reporters was inhibited in cells cotransfected with the IκB kinase β and IkBα superrepressor plasmids. Whereas lactate dehydrogenase, which was used to monitor cell lysis, was released predominantly from the apical surface, CXC chemokines were predominantly secreted from the basolateral surface of BFT‐treated epithelial cells. The basolateral secretion of CXC chemokines from BFT‐stimulated colon epithelial cells suggests that these chemokines can contribute to the inflammatory cell infiltrate in the underlying intestinal mucosa.
Wrist temperature and cortisol awakening response in humans with social jetlag in the North

ABSTRACT The discrepancy between biological and social rhythms known as social jetlag (SJL) is common in modern society and has a range of negative consequences for cognitive functioning, well-being and health. Social jetlag is typical for people with late chronotypes. As shown earlier, the prevalence of individuals with a late chronotype is higher among the residents of high latitudes. Therefore, a higher rate of detection of people with SJL should be expected in the North. In this study we assessed the detection rate of SJL among 62 young inhabitants of the European North of Russia (the Komi Republic), and the relationship between SJL, the circadian rhythm of the wrist temperature, and the cortisol awakening response (CAR). The detection rate of SJL was 65% among the people examined. A significant decrease in the amplitude (A) of circadian rhythm of wrist temperature: (β = −0.34 (CI 95%: −0.66 to −0.33); F1,60 = 10.4; p < 0.0001; η2 = 0.31), an increased incidence of depression: No-SJL = 4.5%; SJL = 17.5% (H = 4.84; p < 0.05), and a tendency for an increase in CAR was also observed in the SJL group. There were sex differences in sensitivity to SJL. Females with SJL but not males had higher global seasonality scores (β = 0.51 (CI 95%: 0.21 to 0.81); F1,33 = 10.9; p < 0.002; η2 =0.24), shorter sleep duration (β = −0.52 (CI 95%: −0.82 to −0.22); F1,33 = 12.9; p < 0.001; η2 = 0.28), worse sleep quality (β = 0.39 (CI 95%: 0.07 to 0.72); F1,33 = 6.31; p < 0.017; η2 = 0.16) and lower A of circadian rhythm of wrist temperature (β = −0.18 (CI 95%: −0.55 to 0.18); F1,33 = 4.48; p < 0.043; η2 = 0.13) compared with females without SJL. Thus, our data indicate that 40 of 62 participants of investigation had social jetlag. A decrease of the amplitude of the circadian rhythm of the wrist temperature appears to be an objective marker of SJL. Social jetlag had a strong negative impact on females but not on males.
Zero-Knowledge-Private Counting of Group Triangles in Social Networks

We introduce a general notion of maturity in social networks that is based on the number of triangles between groups/communities. In order to protect individual privacy upon possible release of such information, we propose privacy mechanisms using zero-knowledge privacy (ZKP), a recently proposed privacy scheme that provides stronger protection than differential privacy (DP) for socialgraph data. We present techniques to compute the parameters required to design ZKP methods and finally evaluate the practicality of the proposed methods.
In Vitro Susceptibilities of Candida andCryptococcus neoformans Isolates from Blood Cultures of Neutropenic Patients

ABSTRACT Fluconazole-resistant Candida albicans and intrinsically fluconazole-resistant Candida species have been reported as bloodstream isolates. However, an association between the isolation of fluconazole-resistant Candida from the bloodstream and patient risk factors for fungemia has not been established. The purpose of this study was to determine the prevalence of fluconazole resistance in bloodstream isolates ofCandida species and Cryptococcus neoformanscollected from patients with neutropenia, one of the most important risk factors for fungemia. MICs of voriconazole, fluconazole, itraconazole, ketoconazole, amphotericin B, and flucytosine were determined by the National Committee for Clinical Laboratory Standards M27-A method (1997). Voriconazole, on a per-weight basis, was the most active azole tested. Fluconazole resistance (MIC ≥ 64 μg/ml) was not identified in any of the C. albicans(n = 513), Candida parapsilosis(n = 78), Candida tropicalis(n = 62), or C. neoformans(n = 38) isolates tested.
Enhanced aggregation of human neutrophils by MnCl2 or DTT differentiates the roles of L‐selectin and β2‐integrins

MnCl2 and dithiothreitol (DTT) enhance the adhesive functions of β2‐integrins. We have used these agents and flow cytometry to distinguish the contributions of β2‐integrins and L‐selectin to neutrophil aggregation. Although neither compound induced aggregation, they prolonged N‐formylmethionyl‐leucyl‐phenylalanine‐induced aggregation and produced larger aggregates. Because activated polymorphonuclear granulocytes (PMN) shed L‐selectin in the presence of MnCl2, but not DTT, we could evaluate the role of L‐selectin in the early and late stages of aggregation. Blocking L‐selectin sites with DREG200 Fab and/or β2‐integrin sites with IB4 Fab indicated that aggregation under all conditions remained β2‐integrin‐ and L‐selectin‐dependent. Disaggregation was integrin‐dependent whether L‐selectin was present or shed. The disaggregation kinetics suggested that integrin bonds turned over at a slower rate in MnCl2‐treated cells. Enhanced aggregation due to DTT and MnCl2 required sustained energy output, suggesting intracellular rather than strictly conformational control. These results provide evidence that PMN aggregation, like leukocyte‐endothelial cell adhesion, utilizes L‐selectin to form intercellular contacts that are maintained through activated integrins. J. Leukoc. Biol. 60: 356–364; 1996.