Miracle-dz/UniFAR-FTUs huggingface dataset:
Depression experience journal: a computer-based intervention for families facing childhood depression.

OBJECTIVE This study tested the feasibility and safety of a computer-based application for families facing childhood depression. The Depression Experience Journal (EJ) is a psychoeducational intervention based on a narrative model involving the sharing of personal stories about childhood depression. METHOD Semistructured interviews assessed Depression EJ feasibility and safety. Thirty-eight primary caretakers of children with depression (one caretaker per patient) used the EJ during a psychiatric hospitalization. Assessment of feasibility and safety was measured before EJ use and 2 to 4 weeks afterward. RESULTS Results revealed that the EJ was safe and useful for decreasing social isolation, increasing hope, increasing understanding of familial feelings about childhood depression, and fostering positive reactions in caretakers. CONCLUSIONS Computer-based interventions hold significant promise in providing a new manner of psychosocial support to families facing child and adolescent psychiatric illnesses.
Precomputation-Based Real-Time Rendering

One of the goals in computer graphics is to generate photorealistic images. Despite the advent of faster computers and more sophisticated algorithms, highquality results can be difficult or impossible to achieve using the traditional rendering pipeline. A relatively new trend in the field is to use acquired data from real images in order to produce high-quality renderings and photorealistic appearances. Commonly referred to as image-based rendering (IBR), this method (in its purest form) completely bypasses the processing of scene geometry. Given the recent successes of this technique, researchers have also started applying the idea to precomputed synthetic data in an effort to achieve offline-rendering quality with real-time rendering speeds. This lecture will explore the technique in detail.
Chinese medicinal herbs for influenza.

BACKGROUND Influenza is a communicable acute respiratory infection which, during epidemics, can cause high morbidity and mortality rates. Traditional Chinese medicinal herbs, often administered following a particular Chinese medical theory, may be a potential treatment of choice. OBJECTIVES To assess the effect of Chinese medicinal herbs used to prevent and treat influenza and to estimate the frequency of adverse effects. SEARCH METHODS We searched CENTRAL (2012, Issue 11), MEDLINE (January 1966 to November week 2, 2012), EMBASE (January 1988 to November 2012) and CNKI (January 1988 to 29 March 2012). We also searched reference lists of articles and the WHO ICTRP search portal (November 2012). SELECTION CRITERIA Randomised controlled trials (RCTs) comparing traditional Chinese medicinal herbs with placebo, no treatment or conventional medicine normally used in preventing and treating uncomplicated influenza. DATA COLLECTION AND ANALYSIS Two review authors independently extracted data and assessed trial quality. MAIN RESULTS We included 18 studies involving 2521 participants. The methodological quality of 17 included studies was poor. Included RCTs separately compared medicinal herbs with different antiviral drugs, precluding any pooling of results. Only three indicated that compared with antiviral drugs, Chinese medicinal herbs may be effective in preventing influenza and alleviating influenza symptoms. 'Ganmao' capsules were found to be more effective than amantadine in decreasing influenza symptoms and speeding recovery in one study (in which adverse reactions were mentioned in the amantadine group although no data were reported). There were no significant differences between 'E Shu You' and ribavirin in treating influenza, nor in the occurrence of adverse reactions. Ten studies reported mild adverse reactions. AUTHORS' CONCLUSIONS Most Chinese medical herbs in the included studies showed similar effects to antiviral drugs in preventing or treating influenza. Few were shown to be superior to antiviral drugs. No obvious adverse events were reported in the included studies. However, current evidence remains weak due to methodological limitations of the trials. More high-quality RCTs with larger numbers of participants and clear reporting are needed.
Perceptions of power: A comparison of perceptions of the organizational power of IT departments

Perceptions of Power: A Comparison of Perceptions of the Organizational Power of IT Departments. (August 2009) Steven Paul Stogsdill, B.A., Hannibal-LaGrange College; M.A., Southwestern Baptist Theological Seminary Chair of Advisory Committee: Dr. Katherine Miller There is a gap in the literature concerning personal perceptions of one’s own power in organizations. Information Technology (IT) personnel are positioned to be an excellent target group for researching this subject. Status Construction Theory (SCT), Mintzberg’s model of organizational structures, and Network Exchange Theory (NET) provide a useful lens for considering the results of this exploratory study. Because power is a widely contested term, a dimensional view of power was used in this study. Twelve indicators of power were identified in the literature and used to create a quantitative survey instrument. Survey participation was solicited online from 350 employees of a small private university in the southwest with a 33% response rate (N=116). In addition, qualitative interviews were conducted with 17 IT professionals and compared with the survey results in a mixed methods approach. The survey did not work as expected. A factorial analysis was used to examine the survey results. However, the factors did not match the twelve power indicators as expected. Also, because of the small sampling size of the survey site, differences
Colon Targeted Delivery Systems: Review of Polysaccharides for Encapsulation and Delivery

Colon-targeted delivery of bioactives has recently gained importance in addressing specific needs in the therapy of colon-based diseases. Many approaches have been attempted for the development of colon-specific delivery systems, with not much success in the past. Recent research into the utilization of the metabolic activity and the colonic microenvironment in the lower gastrointestinal tract has attained great value in the design of novel colon-targeted delivery systems based on natural biodegradable polymers. In the current article, special emphasis has been placed on polysaccharide systems, with minimal chemical modification, that have been exploited for colon targeting. These polysaccharide based encapsulation and targeted delivery systems are envisaged to have an immense potential for the development of food/nutraceutical formulations for colon-based diseases, including colorectal cancer.
Computational and Serologic Analysis of Novel and Known Viruses in Species Human Adenovirus D in Which Serology and Genomics Do Not Correlate

In November of 2007 a human adenovirus (HAdV) was isolated from a bronchoalveolar lavage (BAL) sample recovered from a biopsy of an AIDS patient who presented with fever, cough, tachycardia, and expiratory wheezes. To better understand the isolated virus, the genome was sequenced and analyzed using bioinformatic and phylogenomic analysis. The results suggest that this novel virus, which is provisionally named HAdV-D59, may have been created from multiple recombination events. Specifically, the penton, hexon, and fiber genes have high nucleotide identity to HAdV-D19C, HAdV-D25, and HAdV-D56, respectively. Serological results demonstrated that HAdV-D59 has a neutralization profile that is similar yet not identical to that of HAdV-D25. Furthermore, we observed a two-fold difference between the ability of HAdV-D15 and HAdV-D25 to be neutralized by reciprocal antiserum indicating that the two hexon proteins may be more similar in epitopic conformation than previously assumed. In contrast, hexon loops 1 and 2 of HAdV-D15 and HAdV-D25 share 79.13 and 92.56 percent nucleotide identity, respectively. These data suggest that serology and genomics do not always correlate.
Anesthetic Preconditioning: The Role of Free Radicals in Sevoflurane-Induced Attenuation of Mitochondrial Electron Transport in Guinea Pig Isolated Hearts

Cardioprotection by anesthetic preconditioning (APC) can be abolished by nitric oxide (NO·) synthase inhibitors or by reactive oxygen species (ROS) scavengers. We previously reported attenuated mitochondrial electron transport (ET) and increased ROS generation during preconditioning sevoflurane exposure as part of the triggering mechanism of APC. We hypothesized that NO· and other ROS mediate anesthetic-induced ET attenuation. Cardiac function and reduced nicotinamide adenine dinucleotide (NADH) fluorescence, an index of mitochondrial ET, were measured online in 68 Langendorff-prepared guinea pig hearts. Hearts underwent 30 min of global ischemia and 120 min of reperfusion. Before ischemia, hearts were temporarily perfused with superoxide dismutase, catalase, and glutathione to scavenge ROS or NG-nitro-l-arginine-methyl-ester (l-NAME) to inhibit NO· synthase in the presence or absence of 1.3 mM sevoflurane (APC). APC temporarily increased NADH before ischemia, i.e., it attenuated mitochondrial ET. Both this NADH increase and the cardioprotection by APC on reperfusion were prevented by superoxide dismutase, catalase, and glutathione and by NG-nitro-l-arginine-methyl-ester. Thus, ROS and NO·, or reaction products including peroxynitrite, mediate sevoflurane-induced ET attenuation. This may lead to a positive feedback mechanism with augmented ROS generation to trigger APC secondary to altered mitochondrial function.
TGF-β Plays a Key Role in Morphogenesis of the Pancreatic Islets of Langerhans by Controlling the Activity of the Matrix Metalloproteinase MMP-2

Islets of Langerhans are microorgans scattered throughout the pancreas, and are responsible for synthesizing and secreting pancreatic hormones. While progress has recently been made concerning cell differentiation of the islets of Langerhans, the mechanism controlling islet morphogenesis is not known. It is thought that these islets are formed by mature cell association, first differentiating in the primitive pancreatic epithelium, then migrating in the extracellular matrix, and finally associating into islets of Langerhans. This mechanism suggests that the extracellular matrix has to be degraded for proper islet morphogenesis. We demonstrated in the present study that during rat pancreatic development, matrix metalloproteinase 2 (MMP-2) is activated in vivo between E17 and E19 when islet morphogenesis occurs. We next demonstrated that when E12.5 pancreatic epithelia develop in vitro, MMP-2 is activated in an in vitro model that recapitulates endocrine pancreas development (Miralles, F., P. Czernichow, and R. Scharfmann. 1998. Development. 125: 1017–1024). On the other hand, islet morphogenesis was impaired when MMP-2 activity was inhibited. We next demonstrated that exogenous TGF-β1 positively controls both islet morphogenesis and MMP-2 activity. Finally, we demonstrated that both islet morphogenesis and MMP-2 activation were abolished in the presence of a pan-specific TGF-β neutralizing antibody. Taken together, these observations demonstrate that in vitro, TGF-β is a key activator of pancreatic MMP-2, and that MMP-2 activity is necessary for islet morphogenesis.
The Importance of Morphological Normalization for XML Retrieval

Current information retrieval systems typically ignore structural aspects of documents, solely focusing on the textual content instead. But documents containing additional structure in the form of HTML, XML, or SGML mark-up are pervasive on the Internet. The XML retrieval task presents a number of challenges for information retrieval, for we can no longer rely on the appropriate unit of retrieval to be fixed, or to be known beforehand. This implies that the effectiveness of standard IR techniques, such as morphological normalization methods, may not carry over to this particular task. This paper describes the fully automatic runs for the INEX 2002 task submitted by the Language and Inference Technology Group at the University of Amsterdam. We investigate the effectiveness of two standard approaches to morphological normalization, both a linguistically otivated stemming algorithm and a knowledge-poor character n-gramming technique. Our results show that morphological normalization is an important issue for XML retrieval. For all measurements, the combined run and the n-gram run perform better than the stemmed run.
Analysis of Gene Expression Data 7.1.2 Regulation of Transcription Transcription Factors Work in Combinations Forming Complex Logical Schemes. an Example

As we studied in our first lecture, each cell contains a copy of the whole gene. But we have many tissues that are constructed of different cells, that are responsible for various tasks. Thus, each cell utilizes only a subset of its genes. Most genes are highly regulated their expression is limited to specific tissues, developmental stages, physiological condition. What we would like to find out is how the expression of genes is regulated. Regulation of genes is done in different stages of the gene expression. The process of gene expression is regulated at multiple points including chromatin modifications (during the process of DNA packaging), transcription control (our focus here), splicing, transport and translation control. Biological regulation have more to it than just gene expression regulation , for example, protein interactions and post-translational modification are extremely important in many processes that would not be dealt here. The most common way of regulation is called transcriptional regulation, which will be the main issue discussed in the lecture. It is done during the transcription phase, when the DNA is transcripted into pre-cursone RNA. The regulation of the transcription of a gene is mainly encoded in the DNA in a region called promoter. Each promoter contains several short DNA subsequences, called binding sites (BSs) that are specifically bound by regulatory proteins called transcription factors (TFs) (see Figure 7.1). Transcription factors typically combine to form " transcritpional switches " that encode complex logical functionality to control gene expression given a multitude of biological stimuli. The TF can either encourage or suppress the transcription process. Only when the " right " TF are located, a transcription process can be done. Transcription factors are proteins that bind to DNA region near the gene (the promoter region) at binding sites and regulate its transcription. They attach to the DNA at specific binding sites.
The correlation between dual commitment and industrial relations climate: An empirical study

This study found a positive correlation between dual commitment and positive industrial relations climate while a negative correlation between dual commitment and negative industrial relations climate according to a questionnaire survey with 610 samples in several Wuhan's private enterprises. With a further research by using the Logistic regression model, the affective commitment, normative commitment in organization commitment as well as the member's affection and member's benefits have a remarkable positive impact on positive industrial relations climate, while economic commitment and choice commitment in organization commitment as well as member's affection and member's benefits have a remarkable negative impact on negative industrial relations climate. This essay is conducive to both a correct understanding of unions for the managers of private enterprises and the creation of a harmonious industrial relations climate for the unions.
The War against Proslavery Religion: Abolitionism and the Northern Churches, 1830-1865

Reflecting a prodigious amount of research in primary and secondary sources, this book examines the efforts of American abolitionists to bring northern religious institutions to the forefront of the antislavery movement. John R. McKivigan employs both conventional and quantitative historical techniques to assess the positions adopted by various churches in the North during the growing conflict over slavery, and to analyze the stratagems adopted by American abolitionists during the 1840s and 1850s to persuade northern churches to condemn slavery and to endorse emancipation. Working for three decades to gain church support for their crusade, the abolitionists were the first to use many of the tactics of later generations of radicals and reformers who were also attempting to enlist conservative institutions in the struggle for social change. To correct what he regards to be significant misperceptions concerning church-oriented abolitionism, McKivigan concentrates on the effects of the abolitionists' frequent failures, the division of their movement, and the changes in their attitudes and tactics in dealing with the churches. By examining the pre-Civil War schisms in the Presbyterian, Baptist, and Methodist denominations, he shows why northern religious bodies refused to embrace abolitionism even after the defection of most southern members. He concludes that despite significant antislavery action by a few small denominations, most American churches resisted committing themselves to abolitionist principles and programs before the Civil War. In a period when attention is again being focused on the role of religious bodies in influencing efforts to solve America's social problems, this book is especially timely.
ARE PUBLIC SECTOR EXPATRIATES DIFFERENT IN THEIR CROSS-CULTURAL ADJUSTMENT ?

Although public sector expatriates are becoming increasingly common, research on them is very limited. There is reason to believe that public sector expatriates cross-culturally adjust differently than private sector expatriates. This study investigated U.S. Department of Defense administrators assigned to U.S. embassies worldwide. Results showed that self efficacy, role clarity and role discretion had a positive association with the psychological adjustment of the respondents while role conflict and role overload only had a marginal negative relationship with the criterion variable. Surprisingly, these findings suggest a similar picture for the expatriates from the public and private sector. Implications are discussed in detail.
Phylogenetic Resolution in Juglans Based on Complete Chloroplast Genomes and Nuclear DNA Sequences

Walnuts (Juglans of the Juglandaceae) are well-known economically important resource plants for the edible nuts, high-quality wood, and medicinal use, with a distribution from tropical to temperate zones and from Asia to Europe and Americas. There are about 21 species in Juglans. Classification of Juglans at section level is problematic, because the phylogenetic position of Juglans cinerea is disputable. Lacking morphological and DNA markers severely inhibited the development of related researches. In this study, the complete chloroplast genomes and two nuclear DNA regions (the internal transcribed spacer and ubiquitin ligase gene) of 10 representative taxa of Juglans were used for comparative genomic analyses in order to deepen the understanding on the application value of genetic information for inferring the phylogenetic relationship of the genus. The Juglans chloroplast genomes possessed the typical quadripartite structure of angiosperms, consisting of a pair of inverted repeat regions separated by a large single-copy region and a small single-copy region. All the 10 chloroplast genomes possessed 112 unique genes arranged in the same order, including 78 protein-coding, 30 tRNA, and 4 rRNA genes. A combined sequence data set from two nuclear DNA regions revealed that Juglans plants could be classified into three branches: (1) section Juglans, (2) section Cardiocaryon including J. cinerea which is closer to J. mandshurica, and (3) section Rhysocaryon. However, three branches with a different phylogenetic topology were recognized in Juglans using the complete chloroplast genome sequences: (1) section Juglans, (2) section Cardiocaryon, and (3) section Rhysocaryon plus J. cinerea. The molecular taxonomy of Juglans is almost compatible to the morphological taxonomy except J. cinerea (section Trachycaryon). Based on the complete chloroplast genome sequence data, the divergence time between section Juglans and section Cardiocaryon was 44.77 Mya, while section Rhysocaryon diverged from other sections in the genus Juglans was 47.61 Mya. Eleven of the 12 small inversions in the chloroplast genomes provided valuable phylogenetic information for classification of walnut plants at section and species levels. Our results are valuable for future studies on Juglans genetic diversity and will enhance the understanding on the phylogenetic evolution of Juglandaceae.
Rotation of the Myocardial Wall of the Outflow Tract Is Implicated in the Normal Positioning of the Great Arteries

Congenital heart defects frequently involve a failure of outflow tract (OFT) formation during development. We analyzed the remodeling of the OFT, using the y96-Myf5-nlacZ-16 transgene, which marks a subpopulation of myocardial cells of the pulmonary trunk. Expression analyses of reporter transcript and protein suggest that the myocardial wall of the OFT rotates before and during the formation of the great arteries. Rotational movement was confirmed by Di-I injection experiments with cultured embryos. We subsequently examined the expression of the transgene in mouse models for OFT defects. In hearts with persistent truncus arteriosus (PTA), double outlet right ventricle (DORV), or transposition of the great arteries, rotation of the myocardial wall of the OFT is arrested or fails to initiate. This is observed in Splotch (Pax3) mutants with PTA or DORV and may be a result of defects in neural crest migration, known to affect OFT septation. However, in Pitx2&dgr;c mutant embryos, where cardiac neural crest cells are present in the heart, PTA and DORV are again associated with a rotation defect. This is also seen in Pitx2&dgr;c mutants, which have transposition of the great arteries. Because Pitx2c is involved in left–right signaling, these results suggest that embryonic laterality affects rotation of the myocardial wall during OFT maturation. We propose that failure of normal rotation of OFT myocardium may underlie major forms of congenital heart disease.
κ-Opioid Receptor Activation Modifies Dopamine Uptake in the Nucleus Accumbens and Opposes the Effects of Cocaine

Coadministration of κ-opioid receptor agonists (κ-agonists) with cocaine prevents alterations in dialysate dopamine (DA) concentration in the nucleus accumbens (Acb) that occur during abstinence from repeated cocaine treatment. Quantitative microdialysis was used to determine the mechanism producing these effects. Rats were injected with cocaine (20 mg/kg, i.p.), or saline, and the selective κ-agonist U-69593 (0.32 mg/kg, s.c.), or vehicle, once daily for 5 d. Extracellular DA concentration (DAext) and extraction fraction (Ed), an indirect measure of DA uptake, were determined 3 d later. Repeated cocaine treatment increased Ed, whereas repeated U-69593 treatment decreased Ed, relative to controls. Coadministration of both drugs yielded intermediate Ed values not different from controls. In vitro DA uptake assays confirmed that repeated U-69593 treatment produces a dose-related, region-specific decrease in DA uptake and showed that acute U-69593 administration increases DA uptake in a nor-binaltorphimine reversible manner. Repeated U-69593 also led to a decrease in [125I]RTI-55 binding to the DA transporter (DAT), but did not decrease total DAT protein. These results demonstrate that κ-opioid receptor activation modulates DA uptake in the Acb in a manner opposite to that of cocaine: repeated U-69593 administration decreases the basal rate of DA uptake, and acute U-69593 administration transiently increases DA uptake. κ-agonist treatment also alters DAT function. The action of κ-agonists on DA uptake or DAT binding, or both, may be the mechanism(s) mediating the previously reported “cocaine-antagonist” effect of κ-opioid receptor agonists.