Miracle-dz/UniFAR-FTUs huggingface dataset:
Are We There Yet? Recent Progress in the Molecular Diagnosis and Novel Antifungal Targeting of Aspergillus fumigatus and Invasive Aspergillosis

Are we there yet? Every parent has heard this inexorable question, but it is especially wrenching to hear it from a patient with a fatal illness. When someone, or someone's child, is diagnosed with invasive aspergillosis (IA) caused by Aspergillus fumigatus, the outcome has historically been bleak. In 2013, the field is erupting with exciting advances on multiple scientific fronts. But whether those research findings will improve clinical outcomes is still unclear—does your spouse, child, or neighbor now live or die with this disease? Medical breakthroughs over the last few decades surrounding cancer and transplantation, the main underlying conditions of those afflicted with IA, have been nothing short of astonishing. However, this revolution has also spawned a plethora of immunocompromised patients to inhale fungal spores and develop IA. For many patients with an absent immune system, the second leading cause of death, just behind cancer remission or transplant failure, is infection. The leading infectious cause of death is invasive fungal infections, and the most common mortal fungal infection is A. fumigatus. So have we sufficiently advanced scientifically for today's clinical needs in order to diagnose and treat IA—are we there yet? A. fumigatus is both a beautiful and frustrating fungus. The beauty lies in the pathogen's ability to readily adapt its niche based on the host. The same fungus that lives in compost piles can shear pulmonary blood vessels in immunosuppressed patients, masquerade as an allergic trigger in an ectopic individual, or hide as a saprophyte and slowly sap the strength from an unsuspecting normal host. The frustration with this fungus is the current difficulty in early and accurate diagnosis, a limited number of effective antifungal treatments coupled with the growing emergence of antifungal resistance, and some persistent basic mechanistic questions surrounding its growth and regulation.
Instructions for use Title A New Brain Positron Emission Tomography Scanner with Semiconductor Detectors for TargetVolume Delineation and Radiotherapy Treatment Planning in Patients with Nasopharyngeal Carcinoma

Purpose: We compared treatment planning of stereotactic boost for nasopharyngeal carcinoma (NPC) between using conventional whole-body BGO scintillator positron emission tomography (PET) (PETCONVWB) and using the new brain PET system using semiconductor detectors (PETNEWBR). Methods and Materials: The present study included 12 patients with NPC. 18 F-fluorodeoxyglucose-PET images were acquired with both the PETNEWBR and a PETCONVWB on the same day. CT and two PET data sets were transferred to a treatment planning system, and the PETCONVWB and PETNEWBR images were co-registered with the same set of CT images. The window width and level for all PET images were fixed at 3000 and 300 respectively. The gross tumor volume (GTV) was visually delineated on PET images using either PETCONVWB images (GTVCONV) or PETNEWBR images (GTVNEW). Assuming a stereotactic radiotherapy boost of 7 ports, the prescribed dose delivered to 95% of the planning target volume (PTV) was set to 2000 cGy in 4 fractions. Results: The average absolute volume of GTVNEW was 15.7 ml (standard deviation; SD, 9.9), and that of GTVCONV was 34.0 ml (SD, 20.5). The average of GTVNEW was significantly smaller than that of GTVCONV (p=0.0006). There was no statistically
Optical coherence tomography angiography: an overview of the technology and an assessment of applications for clinical research

In recent years, ophthalmology has experienced significant developments with respect to imaging modalities. Optical coherence tomography angiography is one such technology that seeks to improve diagnostics for retinal diseases. Using standard structural ocular coherence tomography hardware, optical coherence tomography angiography demonstrates the ability to non-invasively visualise the vasculature in the retina and the choroid with high resolution, allowing greater insight into retinal vascular pathologies. In addition, retinal and choroidal vessel density and blood flow can be quantified, offering potential to assist in the diagnosis of a variety of retinal diseases. To date, numerous retinal diseases, such as open-angle glaucoma, have been found to possess a vascular component. Specifically, ischaemia of the optic nerve head and lamina cribrosa has been theorised as a causative factor in ganglion cell death; however, confirmation of this mechanism has been prohibited by the limitations of currently existing imaging modalities. Optical coherence tomography angiography provides clear imaging of these regions and the possibility to elucidate further understanding of vascular factors that contribute to glaucoma development and progression. Furthermore, this imaging modality may provide insight to neural pathologies with vascular components such as Alzheimer's disease. Herein, the authors discuss the theory of operation for optical coherence tomography angiography and the current findings from pilot studies with a focus on open-angle glaucoma. In addition, speculation is offered for future applications of the technology to study other diseases with microvascular contributions.
Transcranial Electrical Stimulation: Methodology and Applications

Low-intensity transcranial current stimulation is a rapidly growing field of research. Transcranial direct current stimulation (tDCS) is the dominant paradigm of this new field, with transcranial alternating current stimulation (tACS) just emerging. Anodal stimulation with tDCS has excitatory effects on the underlying cortex, whereas cathodal stimulation has inhibitory effects. Because both electrodes have significant brain effects when placed at cephalic areas, the term “reference” electrode should be avoided. Most studies have applied tDCS to the motor cortex, the prefrontal cortex, and the occipital cortex. Applications of tDCS include modulation of electrophysiological and hemodynamic brain activity, symptom reduction in neurological and psychiatric pathology, and cognitive improvement in healthy volunteers or clinical populations. There is evidence of motor improvement in patients with stroke, pain reduction in fibromyalgia, improved mood in patients with unipolar or bipolar depression, and reduced c.
Number of Siblings in Childhood Explains Cultural Variance in Autobiographical Memory in Cameroon, People’s Republic of China, and Germany

In the present study, the authors set out to investigate whether number of siblings as a contextual ontogenetic factor can explain cultural variance in autobiographical memory (AM). After replicating the commonly found cultural differences in AM in samples from Asia (PR China, N = 77), Africa (Cameroon, N = 68), and Europe (Germany, N = 100), the authors demonstrate that the number of siblings has a substantial effect on AM variables. The cultural variance explained by the number of siblings ranges from 30% in the age of first memory to 99% in specificity and integration. These findings (a) point towards the necessity to include contextual variables in the investigation of cultural differences in AM and (b) highlight the importance of sensitive periods in early childhood for the development of AM.
A broadband frontend design for UHF RFID tag

This paper presents a complete broadband UHF RFID tag frontend operating in 840/960-MHz band. First a complete RFID system is modeled with Verilog-A. With the optimal quality factor of frontend derived from the system modeling part, a broadband charge pumps (CP) are designed with 0.16um CMOS process. The proposed broadband CP achieves a power conversion efficiency (PCE) of 39.6% at -21.1dBm input RF power. In addition, a broadband commercial use UHF RFID antenna is presented to match the broadband CP. Finally, the co-simulation is performed for the complete frontend design. The simulation result shows that the proposed UHF RFID tag frontend achieves an minimum sensitivity of -21dBm and an maximal power bandwidth larger than 250MHz.
The behaviour of adopted adolescents who spent their infancy in residential group care: the Greek Metera study

The aim of the study was to determine whether adopted children with early experiences of institutional care are at an increased risk of developing behavioural difficulties. The participants were 52 adopted adolescents aged 13 years. The comparison group comprised 36 adolescents of the same age who were brought up in their biological families. The adopted young people were more overactive and inattentive at school compared with those raised in their birth families. No between-group differences were found on feelings of loneliness and social dissatisfaction, on quality of friendships with peers and on self-esteem. Adopted adolescents also tended to be more often referred to psychological services.
Separation of Sensitized and Non-Sensitized RBCs: Sephadex-Based Cell-Affinity Adsorbents

Introduction In transfusion medicine, antibodies that cause RBCs positive DATs, may interfere with patients' phenotyping. Traditionally, these antibodies were removed using various antibody elution methodologies. However, the elution agents and conditions used have been only partially successful; and no one method is superior. The purpose of this study was to develop a general and efficient method to separate non-sensitized from sensitized RBCs using Sephadex-based cell-affinity adsorbents. Methods First, we coupled Sephadex support with Staphylococcal Protein G (SpG) with or without NHS. Then we simulated clinical conditions by mixing differe∏nt ratios of sensitized and non-sensitized RBCs in vitro. Sensitized cells were prepared by mixing antibody with corresponding antigen-positive RBCs. Finally, we checked the sensitization status of absorbed RBCs after absorption with modified Sephadex support. Results The number of sensitized RBCs bound to Sephadex-based cell-affinity adsorbents is approximately 5×108 RBCs/mL support. Activated Sephadex could separate sensitized from non-sensitized RBCs. Conclusion Sephadex-based cell-affinity adsorbents with an NHS spacer arm have bigger capacity for binding RBCs than unmodified Sephadex. The Sephadex-based cell-affinity adsorbents readily separate non-sensitized RBCs from sensitized RBCs, thus providing a new strategy to type the blood for transfused patients.
Healing the Father-Son Relationship: A Qualitative Inquiry into Adult Reconciliation

The father-son relationship holds archetypal power. It is a powerful relationship containing inherent seeds of conflict. Qualitative methods of multiple case studies and grounded theory were used to investigate reconciliation between fathers and sons. A 45-item, 5-point Likert-type scale instrument was developed as a screening measure to determine those fathers and sons who have experienced reconciliation and positive change in their relationship. A 25-item, 5-point Likert-type scale instrument was developed to assess the impact of the interview process on the participants. Through qualitative analyses of interviews from six pairs of fathers and adult sons, eight qualities of a reconciled relationship and 12 factors in the reconciliation process emerged. The process of reconciliation had impacts on these men’s overall well-being and had great personal and transpersonal relevance to the 12 men involved in this study.
The Democratic Origins of the Term `Group Analysis': Karl Mannheim's `Third Way' for Psychoanalysis and Social Science

It is well known that Foulkes acknowledged Karl Mannheim as the first to use the term `group analysis'. However, Mannheim's work is otherwise not well known. This article examines the foundations of Mannheim's sociological interest in groups using the Frankfurt School (1929-1933) as a start point through to the brief correspondence of 1945 between Mannheim and Foulkes (previously unpublished). It is argued that there is close conjunction between Mannheim's and Foulkes's revision of clinical psychoanalysis along sociological lines. Current renderings of the Frankfurt School tradition pay almost exclusive attention to the American connection (Herbert Marcuse, Eric Fromm, Theodor Adorno and Max Horkheimer) overlooking the contribution of the English connection through the work of Mannheim and Foulkes.
Acculturation, Psychological Distress, and Family Adjustment Among Russian Immigrants in the United States

The purpose of this research was to investigate the effect of acculturation differences on psychological distress and family functioning in non-Jewish Russian immigrant families. Potential mediating effects of social support and parenting style and moderating effect of the child’s gender were investigated using regression analysis. The sample consisted of 80 Russian immigrant mother-child dyads residing in the northeast region of the U.S. The study included independent assessment of acculturation to American and Russian cultures. Results confirm the presence of associations between acculturative differences, psychological distress, and family problems. A mediational role of social support and parenting style on the impact of acculturation differences was not found; however, the child’s gender moderated the impact of acculturation differences on psychological distress. In addition, the child’s gender partially moderated the link between acculturation differences and greater mothers’ psychological distress. The findings suggest that acculturation differences have deleterious effects on mental health and family functioning of Russian immigrants.
Cerebellar Cognitive Affective Syndrome Presented as Severe Borderline Personality Disorder

An increasing number of findings confirm the significance of cerebellum in affecting regulation and early learning. Most consistent findings refer to association of congenital vermis anomalies with deficits in nonmotor functions of cerebellum. In this paper we presented a young woman who was treated since sixteen years of age for polysubstance abuse, affective instability, and self-harming who was later diagnosed with borderline personality disorder. Since the neurological and neuropsychological reports pointed to signs of cerebellar dysfunction and dysexecutive syndrome, we performed magnetic resonance imaging of brain which demonstrated partially developed vermis and rhombencephalosynapsis. These findings match the description of cerebellar cognitive affective syndrome and show an overlap with clinical manifestations of borderline personality disorder.
Feeding untreated and pasteurized waste milk and bulk milk to calves: effects on calf performance, health status and antibiotic resistance of faecal bacteria.

Non-saleable milk (waste milk, WM) is contaminated with an undefined spectrum of potentially harmful pathogens and antimicrobial residues. The objective of this study was to determine the impact of feeding bulk milk (BM) or WM - both pasteurized or not - on calf performance, health and the antibiotic resistance of specific faecal bacteria. A total of 114 calves from a large-scale dairy were housed outdoors in individual hutches and were randomly assigned to one of four feeding groups. The calves were fed either WM, pasteurized WM (pWM), BM or pasteurized BM (pBM) from day 3 to 56 of life. Milk samples taken from the pasteurizer and calves' nipple buckets were investigated at regular intervals for total plate count and counts of thermoduric bacteria, coliforms and mastitis pathogens. Faecal samples were taken on days 2, 14, 28 and 56 of life from randomly selected calves of the WM, pWM and BM groups (each N = 8-9) and processed to obtain from each sample preferably two isolates of Escherichia (E.) coli and Enterococcus spp. respectively. Isolates were tested for their antimicrobial susceptibility to 25 antimicrobial agents by broth microdilution. Daily weight gain, milk and calf starter intake and health parameters did not differ significantly between the calves of the four feeding groups. The proportion of resistant E. coli isolates was significantly higher in calves fed WM and in calves fed pWM (most pronounced for cephalosporins) than in calves receiving BM. No differences in resistance were found for Enterococus spp. Thus, the concerns for selecting resistant faecal bacteria by feeding WM seem to be justified. Nonetheless, pasteurized WM of cows not treated with antimicrobials represents an acceptable feed for young calves.
Breast Reduction Using Liposuction with Tumescent Local Anesthesia and Powered Cannulas

BACKGROUND Having large, heavy breasts can be a problem for women. The widely accepted method of breast reduction is excision, but this procedure often leads to a large number of unwanted side effects and complications. There is, therefore, a need for an effective technique that produces fewer of these undesirable features. OBJECTIVE A study was conducted to evaluate the safety and efficacy of liposuction using tumescent local anesthesia (TLA) and powered cannulas. METHODS One hundred fifty-one women were treated. Exact measurements of volume and ptosis were performed before the procedure and at intervals of 6 weeks and 4 months after the procedure. RESULTS The average volume of the breast removed was 53%. Fat was abundant in elderly women and more easily removed because of the progressive fatty involution of the breast. Ptosis reduction was sufficient in women of all ages, with an average of 3.0 cm achieved after 4 months. Patient satisfaction was high, no serious complications were seen, and down-time was minimal. Pre- and postoperative mammograms were taken 1 year after the procedure and showed no new calcifications. CONCLUSION Liposuction using TLA and powered cannulas is a safe and effective treatment modality for breast reduction.
Low-Level Laser Therapy in Enhancing Wound Healing and Preserving Tissue Thickness at Free Gingival Graft Donor Sites: A Randomized, Controlled Clinical Study.

OBJECTIVE The aim of this study was to determine the effects of low-level laser therapy (LLLT) on wound healing at free gingival graft (FGG) donor sites. MATERIALS AND METHODS Forty patients requiring FGG were selected for this randomized, controlled, and double-blinded prospective clinical trial. The FGG donor sites were treated with LLLT and compared with an untreated control group. The Wound-Healing Index (WHI), tissue consistency, color match, and H2O2 bubbling test for the evaluation of complete wound epithelialization were recorded on the 3rd, 7th, 14th and 21st days. The pain-burning level, number of analgesics, and bleeding were recorded for 7 days. Donor area soft tissue thickness (TT) was measured at baseline and at the first month. RESULTS The prevalence of Complete Wound Epithelization was higher in the LLLT group than in the control group on the 14th day (p < 0.001). The bleeding was lower in the test group than in the control group during the first 2 days (p ≤ 0.001). Higher WHI Scores were observed in the test group relative to the control group at all visits (p ≤ 0.001). Color match scores were higher in the test group than in the control group at the first 3 visits (p < 0.05). The TT changed from 4.62 ± 0.79 to 4.71 ± 0.82 mm in the LLLT group and from 4.23 ± 0.62 to 4.01 ± 0.68 mm in the control group. CONCLUSIONS It can be concluded that LLLT enhances FGG donor site wound healing and preserves TT at palatinal donor sites.
Serum zinc, copper, and magnesium levels in obese children

Serum zinc, copper and magnesium levels were measured using atomic absorption spectrophotometry in 41 obese and 41 healthy (control) children (between 7 and 11 years of age) who were living in Malatya (Turkey). Serum zinc levels of obese children (mean value 102.40 ± 2.78 μg/dL) were found to be significantly higher than those of the control group (mean value 80.49 ± 2.98 μg/dL; P < 0.01). Serum copper concentrations were also found to be significantly higher in obese children (mean value 132.34 ± 1.79 μg/dL) than the healthy controls (mean value 107.58 ± 1.62 μg/dL; P < 0.01). On the other hand, serum magnesium levels were found to be significantly lower in obese children (mean value 1.78 ± 0.03 mg/dL) than in the healthy children (mean value 2.14 ± 0.04 mg/dL; P < 0.01).
Reconsidering the Relationship Analogy

Whilst many have grown weary of the claims of relationship marketing (RM) to represent a fundamental shift in marketing thought, critics remain focused upon its unfulfilled claims and, in particular, point to inconsistencies between theory and practice. Although these critiques have merit they tend to retain the assumption that the precepts of RM remain sound and that consequently the 'solution' remains attaining 'better' practice through a revaluation of and commitment to the fundamentals of relationship building. These principles involve the analogous borrowing of key notions of our lived relationships. In this paper we do not set out to dispose of the RM perspective. However we seek to examine how a more sophisticated treatment of the relationship concept in particular by reflecting ambiguities and power dynamics in the sources of the analogies, compels us to produce a re-presentation. Thus we retain the importance of 'relationships' but aim to provoke a more realistic, socially embedded characterisation of consumer engagement with marketing and marketers.
Jointly Learning Energy Expenditures and Activities Using Egocentric Multimodal Signals

Physiological signals such as heart rate can provide valuable information about an individuals state and activity. However, existing work on computer vision has not yet explored leveraging these signals to enhance egocentric video understanding. In this work, we propose a model for reasoning on multimodal data to jointly predict activities and energy expenditures. We use heart rate signals as privileged self-supervision to derive energy expenditure in a training stage. A multitask objective is used to jointly optimize the two tasks. Additionally, we introduce a dataset that contains 31 hours of egocentric video augmented with heart rate and acceleration signals. This study can lead to new applications such as a visual calorie counter.