Miracle-dz/UniFAR-FTUs huggingface dataset:
Proteomic and phosphoproteomic alterations in benign, premalignant and tumor human breast epithelial cells and xenograft lesions: Biomarkers of progression

The MCF10A human breast epithelial cell lineage includes the benign MCF10A cells, premalignant cells (MCF10AT, MCF10ATG3B) and malignant MCF10CA1a tumor cells. The premalignant and tumor cells recapitulate the progressive alterations associated with the temporal development of PBD and carcinoma. Ras protein levels were elevated by 6.9‐, 22.4‐ and 32.2‐fold in 10AT, 10ATG3B and 10CA1a cells, respectively, relative to 10A cells. K‐Ras was not detected, N‐Ras levels were unchanged; Rac and Rho levels increased in 10CA1a tumor cells. Phospho‐phosphatidylinositol 3‐kinase, phosphoinositide‐dependent protein kinase 1 (PDK1), phospho‐PDK1, phospho‐eukaryotic translation initiation factor 4E (eIF4E) and phospho‐eukaryotic initiation factor 4E binding protein 1 (4E‐BP1) levels progressively increased in the cell lineage, with the greatest increase monitored in 10CA1a tumor cells. Phospho Ser 473 and Thr 408 Akt levels increased 10.2‐ and 136‐fold in 10CA1a cells, respectively, relative to 10A cells. Phospho‐p70S6 kinase (p70S6K) increased >2‐fold in 10CA1a cells, relative to 10A cells. Immunohistochemistry confirmed Ras, phospho‐Akt and phospho‐p70S6K (Thr 421/ Ser 424) expression in lesions arising from premalignant and tumor cells. FOXO 1, phospho‐FOXO 1 and phospho‐FOXO 4 were significantly elevated in 10ATG3B premalignant and 10CA1a tumor cells. Phospho‐FOXO 3a was progressively elevated, with the greatest levels detected in 10CA1a tumor cells. Immunohistochemistry revealed that phospho‐FOXO 1, 3a and 4 staining was less in benign lesions, but elevated in advanced 10ATG3B and malignant 10CA1a lesions, showing a correspondence between the cells and lesions. Hence, phospho‐Akt and phospho‐FOXO 1, 3a and 4 merit consideration as biomarkers of tumorigenic risk from hyperplastic breast tissue. © 2009 UICC
Unification in 5D SO(10)

Gauge unification in a five dimensional supersymmetric SO(10) model compactified on an orbifold S1/(Z2 ? Z2') is studied. One orbifolding reduces N = 2 supersymmetry to N = 1, and the other breaks SO(10) to the Pati-Salam gauge group SU(4)C ? SU(2)L ? SU(2)R. Further breaking to the standard model gauge group is made through the Higgs mechanism on one of the branes. The differences of the three gauge couplings run logarithmically even in five dimensions and we can keep the predictability for unification as in four dimensional gauge theories. We obtain an excellent prediction for gauge coupling unification with a cutoff scale M* ~ 3 ? 1017 GeV and a compactification scale Mc ~ 1.5 ? 1014 GeV. Finally, although proton decay due to dimension 5 operators may be completely eliminated, the proton decay rate in these models is sensitive to the placement of matter multiplets in the 5th dimension, as well as to the unknown physics above the cutoff scale.
The Standardized Incidence Ratio as a Reliable Tool for Surgical Site Infection Surveillance

Objective. To evaluate whether the standardized incidence ratio (SIR) is a more reliable tool for comparing rates and temporal trends of surgical site infection (SSI) in surgery wards than the incidence rate among patients with an National Nosocomial Infections Surveillance system (NNIS) risk index category of 0. Design. Observational, prospective cohort study in a sequential SSI surveillance system. Setting. Volunteer surgery wards in a surveillance network in northern France that annually conducted SSI surveillance for 3 months from 1998 to 2000. Methods. The incidence rate was the number of SSIs divided by the number of patients included, stratified by the NNIS risk index category. SIR was the observed number of SSIs divided by the expected number computed using a multiple regression model. Results. Overall, 26,904 patients in 67 surgery wards were enrolled. Between 1998 and 2000, the SSI incidence rate among patients with NNIS risk index category 0 decreased from 2.1% to 1.4%, which was a 33% reduction (P = .002). The SIR decreased from 1.2 (95% confidence interval [CI], 1.1-1.3) to 0.8 (95% CI, 0.7-0.9), which was a 20% decrease per year and an overall 33% reduction. The number of SSIs was significantly higher than expected in 17 of 201 surveillance periods over the 3 years. The classification of the wards according to the 2 indicators over the 3 years showed that wards with a high SIR did not consistently have the highest SSI incidence rate among patients with NNIS risk index category 0, partly because the type of surgical procedure and the duration of follow-up are not taken into account in the NNIS risk index. Conclusion. SIR should be considered a reliable indicator to estimate the reduction in SSI incidence that results from implementation of infection control policies and for comparison of SSI rates between wards.
Pilot study on the impact of VLE on mathematical concepts acquisition within secondary education in England

The research investigates the “impact of VLE on mathematical concepts acquisition of the special education needs (SENs) students at KS4 secondary education sector” in England. The overall aim of the study is to establish possible areas of difficulties to approach for above or below knowledge standard requirements for KS4 students in the acquisition and validation of basic mathematical concepts. A teaching period, in which virtual learning environment (Fronter) was used to emphasise different mathematical perception and symbolic representation was carried out and task based survey conducted to 20 special education needs students [14 actually took part]. The result shows that students were able to process information and consider images, objects and numbers within the VLE at early stages of acquisition process. They were also able to carry out perceptual tasks but with limiting process of different quotient, thus they need teacher’s guidance to connect them to symbolic representations and sometimes coach them through. The pilot study further indicates that VLE curriculum approaches for students were minutely aligned with mathematics teaching which does not emphasise the integration of VLE into the existing curriculum and current teaching practice. There was also poor alignment of vision regarding the use of VLE in realisation of the objectives of teaching mathematics by the management. On the part of teacher training, not much was done to develop teacher’s skills in the technical and pedagogical aspects of VLE that is in-use at the school. The classroom observation confirmed teaching practice will find a reliance on VLE as an enhancer of mathematical skills, providing interaction and personalisation of learning to SEN students.
The Effects of $\alpha$-Wave Music and Art Appreciation on Hand Function in Patient with Stroke

Purpose：The purpose of this study was to investigate the effect of -wave music and art appreciation on hand function in stroke with hemiplegia. Methods：A total of 32 stroke with hemiplegia participated in this study experimental group(16 subjects) received -wave music and art appreciation with general neurologic therapy. Control group(16 subjects) received general neurologic therapy. All subjects were assessed for hand function(manual dexterity, power grip, pinch grip, two point discrimination(parm, finger), tactile sense(parm, finger) using a purdue pegboard, dynamometer, pinch gauge, two-point anethesiometer and semmes-weinstein monofilament wire. The data were analyzed using paired and independent t-test. Results：The results were as follows : 1. In the experimental group, manual dexterity were significantly increased between pre and post intervention(p-wave music and art appreciation affect the hand function of hemiplegic side with regard to manual dexterity and tactile sense.
CONTROL OF PIGMENT PRODUCTION IN MOUSE MELANOMA CELLS IN VITRO

A clonally derived amelanotic melanoma cell line repeatedly has been forced to produce pigment by the inhibitor of DNA synthesis, I-β-D-arabinofuranosylcytosine (ara-C) at sublethal levels. One ara-C-derived melanotic line has been cloned, and has continued to produce pigment for 2 years on normal medium. The inhibitor is most effective when administered to synchronized cells in four pulses on successive days at 1.8 x 10-5 M during the S phase of the cell cycle. Colcemid at a sublethal concentration, and growth on medium solidified with agar also evoked pigment production in this line, but a large number of other inhibitors of biosynthetic processes did not, under the conditions tested. The melanotic lines are active producers of tyrosinase (DOPA oxidase), whereas the amelanotic line produces an inhibitor of tyrosinase activity. Both enzyme and inhibitor are labile at 4° C and -20° C, and decay of the inhibitor in homogenates of amelanotic cells reveals a low level of residual DOPA oxidase activity. The mean population doubling time of a cloned melanotic line is 23 hr, and that of a cloned amelanotic line 16.5 hr. A similar decrease in rate of growth is found in other melanotic lines and is believed to be a significant factor in maintaining this differentiated function. Rapid growth may be related to the production of an inhibitor by the amelanotic cells.
Successful treatment with 4‐phenylbutyrate in a patient with benign recurrent intrahepatic cholestasis type 2 refractory to biliary drainage and bilirubin absorption

Benign recurrent intrahepatic cholestasis type 2 (BRIC2) is caused by mutations in ABCB11, a gene encoding the bile salt export pump (BSEP) that mediates biliary bile salt secretion, and presents with repeated intermittent cholestasis with refractory itching. Currently, no effective medical therapy has been established. We previously provided experimental and clinical evidence suggesting the therapeutic potential of 4‐phenylbutyrate (4PB) for the cholestatic attacks of BRIC2.
Precision timed infrastructure: Design challenges

In general-purpose software applications, computation time is just a quality factor: faster is better. In cyber-physical systems (CPS), however, computation time is a correctness factor: missed deadlines for hard real-time applications, such as avionics and automobiles, can result in devastating, life-threatening consequences. Although many modern modeling languages for CPS include the notion of time, implementation languages such as C lack any temporal semantics. Consequently, models and programs for CPS are neither portable nor guaranteed to execute correctly on the real system; timing is merely a side effect of the realization of a software system on a specific hardware platform. In this position paper, we present the research initiative for a precision timed (PRET) infrastructure, consisting of languages, compilers, and microarchitectures, where timing is a correctness factor. In particular, the timing semantics in models and programs must be preserved during compilation to ensure that the behavior of real systems complies with models. We also outline new research and design challenges present in such an infrastructure.
Mentoring collaborative user centred design

User-centred design is a key part of best practice website design, but becomes increasingly difficult when undertaken by an inexperienced, multidisciplinary team gathered from various parts of an organisation. Mentoring is one approach that can help alleviate the pressure and assist such a team in delivering solid results. This paper describes the experiences of a team and its mentor during the ground-up redesign of a website for an Australian government agency, referred to by the pseudonym 'ESA' in this paper.
Queering the social emergence of disabled sexual identities: Linking queer theory with disability studies in the South African context

abstract People with disabilities share many similar experiences to lesbian, gay, bisexual, transgender and intersex (LGBTI) people. Besides a history of ongoing activism, sexual minorities and disabled people share a history of social injustice, oppression and isolation. Perhaps the most compelling intersection is found in the respective disciplines of queer theory and disability studies, which both challenge hegemonic constructs of normalcy. Despite this, there have been few attempts to combine both disciplines within an African context. This absence comes as no surprise, especially given the fact that youth and adults with disabilities are typically constructed as de-gendered and asexual. Given this lack of reciprocity, this article explores the intersections between queer theory and disability studies in the construction of disabled sexual identities in the South African context. The significance of this article is not just that a number of people with disabilities identify as LGBTI or vice versa, but the fact that queer theory can challenge and extend current debates surrounding disabled sexual identities in South Africa. Correspondingly, disabled sexualities have the potential to queer constructs of African sexualities.
Qualitative Research Methodologies for Occupational Science and Therapy

1. Beginning Conversations Shoba Nayar & Mandy Stanley 2. Deepening Understandings Mandy Stanley & Shoba Nayar 3. Qualitative Descriptive: A very good place to start Mandy Stanley 4. Grounded Theory: Uncovering a world of process Shoba Nayar 5. Doing (Interpretive) Phenomenology Valerie Wright-St. Clair 6. Narrative Methodology: A tool to access unfolding and situated meaning in occupation Staffan Josephsson & Sissel Alsaker 7. Ethnography: Understanding occupation through an examination of culture Suzanne Huot 8. Action Research: Exploring occupation and transforming occupational therapy Clare Wilding & Danika Galvin 9. Case Study Methodology: The particular and the whole Margaret Jones & Clare Hocking 10. Critical Discourse Analysis: Opening possibilities through deconstruction Debbie Laliberte Rudman & Silke Dennhardt 11. Visual Methodologies: Photovoice in focus Eric Asaba, Debbie Laliberte-Rudman, Margarita Mondaca & Melissa Park 12. Meta-Synthesis Demystified: Connecting islands of knowledge Carolyn Murray & Mandy Stanley 13. Appreciative Inquiry: Enabling occupation through the envisioning mind Jenni Mace, Clare Hocking & Marilyn Waring 14. Interrogating Power and Reason: Critical theory and philosophy Ben Sellar 15. Closing Conversations Shoba Nayar, Mandy Stanley, Eric Asaba, Debbie Laliberte Rudman, Clare Wilding & Valerie Wright-St.Clair
Provable data possession at untrusted stores

We introduce a model for provable data possession (PDP) that allows a client that has stored data at an untrusted server to verify that the server possesses the original data without retrieving it. The model generates probabilistic proofs of possession by sampling random sets of blocks from the server, which drastically reduces I/O costs. The client maintains a constant amount of metadata to verify the proof. The challenge/response protocol transmits a small, constant amount of data, which minimizes network communication. Thus, the PDP model for remote data checking supports large data sets in widely-distributed storage system. We present two provably-secure PDP schemes that are more efficient than previous solutions, even when compared with schemes that achieve weaker guarantees. In particular, the overhead at the server is low (or even constant), as opposed to linear in the size of the data. Experiments using our implementation verify the practicality of PDP and reveal that the performance of PDP is bounded by disk I/O and not by cryptographic computation.
Feature Fusion of Palm and Face Based on Curvelet Transform

This paper presents feature level fusion approach using multi resolution Curvelet transform for face and palm biometrics.In this paper feature extraction has been done by taking the curvelet transform of bit quantized images.The curvelet coefficient thus obtained acts as feature set for classification.The five sets of coefficients from five different versions of images are used to train five SVMs.During testingthe results of SVMs of palm and face are fused in a single column feature vector to determine the final classification.The results of fusion are compared with that of unimodal biometric system of palm and face separately.Using a common feature extraction method for both unimodal and fusion helps in analyzing the efficiency of recognition.The experimental results show that the proposed scheme out performs the unimodal biometrics using curvelet transform.All the experiments are carried out on two well-known data bases AT&T for face and POLY U for palm print images.
Are you bored?: Maybe an interface agent can help!

In this paper we present the influence of Emotive Interface Agents on task-induced boredom. We studied the effects of two agents --- friendly and unfriendly. The results show that, like human-human interaction, emotional contagion can happen between agents and users and that it can lead to reduction in task induced boredom. As expected, the friendly agent proved to be more successful in reducing boredom and maintaining participants' focus on task than the unfriendly agent. Moreover, participants felt that the friendly agent added stimulation to the task. This indicates that the friendly agent had some influence on the perception of the task. However, the effects of the unfriendly agent should not be downplayed. Even though the unfriendly agent was perceived as irritating and annoying, a majority of the participants felt that the agent masked the boredom and the monotony of performing a simple repetitive task. More surprisingly many participants found it entertaining to interact with the unfriendly agent, implying counter contagion of emotions. Given the findings of this study, we believe that agents have great potential in regulating emotions. We believe these agents can be successfully used in everyday monotonous/boring tasks such as e-form filling and data entry. With further research we also believe that agents can be extended into learning environments to assist in regulating emotions in learners.
THE TAXONOMIC SIGNIFICANCE OF FERMENTATIVE VERSUS OXIDATIVE METABOLISM OF CARBOHYDRATES BY VARIOUS GRAM NEGATIVE BACTERIA

For many years bacteriologists have observed that some bacteria produce acid from carbohydrates only under aerobic conditions while others produce acid both under aerobic and anaerobic conditions. The significance of these observations does not seem to have been appreciated generally by taxonomists. Studies of bacterial physiology have made it increasingly evident that the bacterial metabolism of carbohydrates may be accomplished by two apparently fundamentally different mechanisms (see for example Porter, 1946; Werkman and Wilson, 1951). By one mechanism, appropriately called fermentation, the glucose molecule first is phosphorylated and then split into two triose molecules which undergo further changes. This process is independent of oxygen. By the other mechanism, which we shall call oxidation, the glucose molecule is not split into two triose molecules, but the aldehyde group is oxidized to a carboxyl group forming gluconic acid. Further oxidation may take place to form various products such as 2-ketogluconic acid. Several studies of this mechanism, summarized by Sebek and Randles (1952), have failed to detect phosphorylation of the glucose molecule preliminary to oxidation. In the absence of compounds such as nitrates, the oxidation of carbohydrates is a strictly aerobic process, whereas fermentation is an anaerobic process.
Different Channel coding techniques in MIMO-OFDM

This Paper is containing the different types of Channel Coding which is used in multiple input multiple output orthogonal frequency division multiplexing (MIMO-OFDM). To increase the efficiency of MIMO-OFDM there are several channel coding are applied in it.in this paper the aim is to show the discussion about all channel coding which are used as well as using in MIMO-OFDM system. This paper is structured in such way that in section I OFDM System and channel coding is described, in II section there is discussion about block diagram.In III section there is discussion of formula used in FFT and IFFT. In section IV several channel coding are defined which are used in MIMO-OFDM system. Further conclusion is made in section V.
Saliency moments for image categorization

In this paper we present Saliency Moments, a new, holistic descriptor for image recognition inspired by two biological vision principles: the gist perception and the selective visual attention. While traditional image features extract either local or global discriminative properties from the visual content, we use a hybrid approach that exploits some coarsely localized information, i.e. the salient regions shape and contours, to build a global, low-dimensional image signature. Results show that this new type of image description outperforms the traditional global features on scene and object categorization, for a variety of challenging datasets. Moreover, we show that, when combined with other existing descriptors (SIFT, Color Moments, Wavelet Feature and Edge Histogram), the saliency-based features provide complementary information, improving the precision of a retrieval system we build for the TRECVID 2010.
Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival

Indefinite graft survival was obtained with murine cardiac allografts using the combined administration of monoclonal antibodies (mAbs) directed against the receptor ligand pair CD2-CD48. Although each antibody could prolong graft survival when given alone, neither resulted in the indefinite graft survival seen with the combination. Combined mAb administration is associated with inhibition of T cell priming and help and subsequent cytotoxic T lymphocyte generation. This indicates that the interaction between CD2 and its ligand is important for antigen priming and recognition, and combined mAbs may prove to be a useful therapeutic regimen for transplantation.
Interpretation of Coherence Phase and Rhythmic Cumulant Results; A Simulation Study

The interpretation of the cumulant plots, an analysis method often used in electrophysiology studies is not straight forward. The results show activity that does not always have direct implications towards understanding the underlying neurophysiological processes. Previous work has shown elements of connection between neuronal structures and coherent activity, however not in a consistent way. In this paper, simulations of simple neuronal networks appearing in the literature and the resulting cumulant plots will be combined with a consistent simulation study that aims to recreate some of the presented results and generate some new in order to give insight to the interpretation of the cumulant analysis results and frequency domain results. The aim is to help towards understanding the cumulant analysis and frequency domain results. Neurones receiving a common excitatory input, neurones receiving a common inhibitory input, neurones having common oscillatory inputs and neurones with non oscillatory inputs producing oscillatory output were examined regarding the coherence and frequency spectra results.