Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors Influencing Success and Failure of Health Informatics Systems

Summary Objectives: The aim is to gain information on factors influencing success and failure for Health Informatics applications from a group of medical informaticians. Methods: Based on the presentations at a special topic conference on success and failure in Health ICT and analysis of the proceedings, we conducted a Delphi study on success and failure aspects. Results: A total of 110 success factors and 27 failure criteria were identified, distributed on categories like functional, organizational, behavioral, technical, managerial, political, cultural, legal, strategy, economy, education and user acceptance. These factors and criteria were rated for six different system types. Unanimously it was agreed that “collaboration and co-operation” and “setting goals and courses” are “essential for the success” of clinical systems, and “user acceptance” for educational systems. Similarly, the score “essential in order to avoid a failure” were given unanimously on clinical systems for “response rate and other performance measures” and on administrative systems for “not understanding the organizational context” with “not understanding or foreseeing the extent to which the new IT-system affects the organization, its structure and/or work procedures” as the highest scoring sub-item. Conclusions: All success factors and failure criteria were considered relevant by the Delphi expert panel. There is no small set of relevant factors or indicators, but success or failure of a Health ICT depends on a large set of issues. Further, clinical systems and decision support systems depend on more factors than other systems.
Genetic linkage and association studies in bipolar affective disorder: A time for optimism

Genetic research on complex diseases is beginning to bear fruit, with the successful identification of candidate susceptibility genes in diabetes, asthma, and other illnesses. Similar success is on the horizon for bipolar affective disorder (BPAD), but significant challenges remain. In this review, we outline the basic concepts of linkage and association mapping for complex phenotypes. We point out important caveats inherent in both approaches, and review guidelines on the interpretation of linkage statistics and significance thresholds. We then apply these concepts to an evaluation of the present status of genetic linkage and association studies in BPAD. The challenges posed by locus heterogeneity, phenotype definition, and sample size requirements are given a detailed treatment. Despite these challenges, we argue that the way ahead remains firmly rooted in linkage studies, complemented by association studies in linked regions. This is the only truly genome‐wide approach currently available; it has succeeded in other complex phenotypes, and it is the surest strategy for mapping susceptibility genes in BPAD. Once these genes are identified, genetic mapping methods will yield to the other methods of 21st‐century molecular biology as we begin to elucidate the pathophysiology of BPAD. © 2003 Wiley‐Liss, Inc.
Complete genome sequence of strain HIMB 100 , a cultured representative of the SAR 116 clade of marine Alphaproteobacteria

Jana Grote, Cansu Bayindirli, Kristin Bergauer, Paula Carpintero de Moraes, Huan Chen, Lindsay D’Ambrosio, Bethanie Edwards, Beatriz Fernández-Gómez, Miriam Hamisi, Ramiro Logares, Dan Nguyen, Yoshimi M. Rii, Emily Saeck, Charles Schutte, Brittany Widner, Matthew J. Church, Grieg F. Steward, David M. Karl, Edward F. DeLong, John M. Eppley, Stephan Schuster, Nikos C. Kyrpides, and Michael S. Rappé*
Daughters' journey to father's role in family business in China: Patterns and stages

Father-daughter succession remains rare in family business as evidenced by limited number of female leaders in business. Existing research on this topic is exclusively based on western countries. With the rise of family firms in China in the late 1970s, many founders found themselves approaching retirement age and need to consider succession issue. The strong desire of keeping business within a family in Chinese society implies children are preferred successors. Daughters have been increasingly considered and trained as the successors for family business in China. This paper explores father-daughter succession in family firms based on interviews of four female successors in China. The four cases present distinctive stages of succession and reveal deep influence of Confucianism in various aspects of father-daughter succession as well as challenges faced female successors in male dominant industries.
Magnetic-resonance imaging techniques for detection of elasticity variation.

The relative success of manual palpation in the detection of breast cancer would suggest that a method for remote palpation resulting in a measurement of tissue elasticity could provide a diagnostic tool for detecting cancerous lesions deeper within the breast. This presumption is based in part on the excellent contrast between neoplastic and normal tissue due to the large (orders of magnitude) relative variation in the shear elastic modulus. By comparison, the bulk deformational modulus maintains the same value to within 20% for most soft tissues. A specific method of magnetic-resonance imaging (MRI) which measures tissue displacements has been used in experiments with a phantom containing regions of increased Young's modulus as a demonstration. The spatial modulation of magnetization technique uses the displacement of a spatial grid pattern caused by spin saturation to track regional motion. Mathematical reconstruction of the distribution of elastic moduli is shown for select examples. Any modality, e.g., MRI, ultrasound, etc., which can detect local tissue motion with sufficient spatial resolution can be used and therefore the results presented here should give an indication of the utility of such motion tracking techniques to future measurement of tissue elasticity.
Dynamics of Optimal Balance Between Exploration and Exploitation: In the View of Capability and Embeddedness

Although existing ambidexterity literature suggests that firms need to balance between exploration and exploitation for superior performance, few studies have empirically examined the dynamic change of a firm’s optimal balance between exploration and exploitation. Building upon the capability and embeddedness perspectives, this research investigates how the varying level of a firm’s technological capability and network position within industry alliances affects the location of the optimal balance point of the firm. Analyzing 7-year panel data in the worldwide semiconductor industry from 1994 to 2000, I find support for the following hypotheses: 1) the proportion of exploration has an inverted-U-shaped relationship with innovation performance; 2) as a firm’s technological capability is enhanced, its optimal point between exploration and exploitation moves toward the exploration side; 3) as a firm’s network position within industry alliances is central, the optimal point moves toward the exploitation side. The results offer theoretical insights into the dynamic nature of ambidexterity as well as the managerial implications for resource-allocation decisions.
Estimating Camera Tilt from Motion without Tracking

Most methods for automatic estimation of external camera parameters (e.g., tilt angle) from deployed cameras are based on vanishing points. This requires that specific static scene features, e.g., sets of parallel lines, be present and reliably detected, and this is not always possible. An alternative is to use properties of the motion field computed over multiple frames. However, methods reported to date make strong assumptions about the nature of objects and motions in the scene, and often depend on feature tracking, which can be computationally intensive and unreliable. In this paper, we propose a novel motion-based approach for recovering camera tilt that does not require tracking. Our method assumes that motion statistics in the scene are stationary over the ground plane, so that statistical variation in image speed with vertical position in the image can be attributed to projection. The tilt angle is then estimated iteratively by nulling the variance in rectified speed explained by the vertical image coordinate. The method does not require tracking or learning and can therefore be applied without modification to diverse scene conditions. The algorithm is evaluated on four diverse datasets and found to outperform three alternative state-of-the-art methods.
Sustainable consumption profile differences among Brazilian regions

Brazil is a vast country and there are several scientific studies reporting sustainable behavior in its different regions. Since methodologies used in these studies differ from one another, it is hard to compare them. This paper aims to identify whether differences in sustainable behavior occur in different Brazilian regions and what differences can be identified. Through a web survey, we analyzed data from 1,489 participants, from four different regions. We identified two factors (behavior and search for information), and analyzed the differences through multivariate analysis of variance. The Northeast region had a higher score for “search for information”, while Southern regions performed better on “behavior. ” The Midwest region had the worst performance for both factors. The reasons for such differences may be greatly influenced by the social/cultural context of each region. The results also show that consumers still do not use their power of choice to pressure companies to become more sustainable.
Biologics and immunomodulators for treating Crohn’s disease developing after surgery for an initial diagnosis of ulcerative colitis: a review of current literature

Abstract Crohn’s Disease (CD) or CD-like (CDL) conditions of the pouch are rare long-term inflammatory complications of patients who were initially diagnosed with ulcerative colitis (UC) who undergo total proctocolectomy with ileo-anal anastomosis (IPAA). There are no societal guidelines nor a consensus on their treatment, resulting in significant challenges for clinicians for their diagnosis and management. It is important to differentiate them from other more common pouch-related complications like pouchitis, cuffitis, irritable pouch syndrome, surgery associated stricture, and fistula. In this review, we focus on the less common presentation of CD and CDL conditions of the pouch and their treatment with the use of anti-TNF therapy with or without immunomodulator.
Activation of QA devices and phantom materials under clinical scanning proton beams—a gamma spectrometry study

Activation of detectors and phantoms used for commissioning and quality assurance of clinical proton beams may lead to radiation protection issues. Good understanding of the activation nuclide vectors involved is necessary to assess radiation risk for the personnel working with these devices on a daily basis or to fulfill legal requirements regarding transport of radioactive material and its release to the public. 11 devices and material samples were irradiated with a 220 MeV proton pencil beam (PBS, Proton Therapy Center, Prague). This study focuses on devices manufactured by IBA Dosimetry GmbH: MatriXX PT, PPC05, Stingray, Zebra, Lynx, a Blue Phantom rail and samples of RW3, PMMA, titanium, copper and carbon fibre plastic. Monitor units (MU) were monitored during delivery. Gamma spectrometry was then performed for each item using a HPGe detector, with a focus on longer lived gamma emitting radionuclides. Activities were quantified for all found isotopes and compared to relevant legal limits for exemption and clearance of radioactive objects. Activation was found to be significant after long irradiation sessions, as done during commissioning of a proton therapy room. Some of the investigated devices may also cumulate activity in time, depending on the scenario of periodic irradiation in routine clinical practice. However, the levels of activity and resulting beta/gamma doses are more comparable to internationally recommended concentration limits for exemption than to dose limits for radiation workers. Results of this study will help to determine nuclide inventories required by some legal authorities for radiation protection purposes.
Major sperm protein and actin genes in free-living and parasitic nematodes

SUMMARY The DNA from a number of free-living and parasitic nematode species was examined to determine the genomic number and distribution of DNA sequences encoding two evolutionary conserved proteins; the major sperm protein (MSP) and nematode actin. Ascaris and Caenorhabditis MSP cDNA sequences and Ascaris genomic actin sequences were used to probe Southern blots of Eco RI and Hin d III digested nematode DNA. The number of MSP genes varied widely between the 1 MSP gene in Ascaris and the 60 MSP genes in Caenorhabditis. Filarial nematodes appeared to have 1—4 MSP genes while the plant and insect parasitic species showed from 5–12 MSP-hybridizing restriction fragments. Mammalian intestinal parasites showed between 1 and 13 bands hybridizing with the MSP probes. Blots probed to estimate the number of actin genes showed that, with the exception of Ascaris which contains more than 20 germ line sequences that encode actin, all of the nematodes tested had between 3 and 9 bands that hybridized to the Ascaris genomic actin probe. The possible use of highly conserved sequences such as MSP and actin to differentiate between nematode species in diagnostic and taxonomic studies is discussed.
Consensus function based on multi-layer networks technique

One of the great aspirations of machine learning is the clustering methods. It consists on categorized a set of similar data into different groups based on related properties. The clustering ensemble is used in aim to improve the performance and the stability of the unsupervised classification methods through the concept of weighting. One of the major problems in clustering ensembles is the consensus function. In this paper, we study the amalgamation of clustering techniques, trying to benefit from the strengths of each algorithm and we emerge the problem of combining multiple clustering of a set of objects. A new efficient for Consensus Functions of Cluster Ensembles is proposed based on Multi-layer networks technique. Experiments are carried out on a variety of datasets which highlights our proposed method.
Tropical Cyclone Projections: Changing Climate Threats for Pacific Island Defense Installations

Potential changing climate threats in the tropical and subtropical North Pacific Ocean were assessed, using coupled ocean–atmosphere and atmosphere-only general circulation models, to explore their response to projected increasing greenhouse gas emissions. Tropical cyclone occurrence, described by frequency and intensity, near islands housing major U.S. defense installations was the primary focus. Four island regions—Guam and Kwajalein Atoll in the tropical northwestern Pacific, Okinawa in the subtropical northwestern Pacific, and Oahu in the tropical north-central Pacific—were considered, as they provide unique climate and geographical characteristics that either enhance or reduce the tropical cyclone risk. Guam experiences the most frequent and severe tropical cyclones, which often originate as weak systems close to the equator near Kwajalein and sometimes track far enough north to affect Okinawa, whereas intense storms are the least frequent around Oahu. From assessments of models that simulate well the tropical Pacific climate, it was determined that, with a projected warming climate, the number of tropical cyclones is likely to decrease for Guam and Kwajalein but remain about the same near Okinawa and Oahu; however, the maximum intensity of the strongest storms may increase in most regions. The likelihood of fewer but stronger storms will necessitate new localized assessments of the risk and vulnerabilities to tropical cyclones in the North Pacific.
Public Integrity Auditing for Shared Dynamic Cloud Data with Group User Revocation

The advent of the cloud computing makes storage outsourcing become a rising trend, which promotes the secure remote data auditing a hot topic that appeared in the research literature. Recently some research consider the problem of secure and efficient public data integrity auditing for shared dynamic data. However, these schemes are still not secure against the collusion of cloud storage server and revoked group users during user revocation in practical cloud storage system. In this paper, we figure out the collusion attack in the exiting scheme and provide an efficient public integrity auditing scheme with secure group user revocation based on vector commitment and verifier-local revocation group signature. We design a concrete scheme based on the our scheme definition. Our scheme supports the public checking and efficient user revocation and also some nice properties, such as confidently, efficiency, countability and traceability of secure group user revocation. Finally, the security and experimental analysis show that, compared with its relevant schemes our scheme is also secure and efficient.
Physical activity and mortality in frail, community-living elderly patients.

BACKGROUND The authors describe the prevalence of moderate-intensity physical activity in a population of older persons living in the community. In addition, they explore the relationship between physical activity and mortality. METHODS In this longitudinal observational study, the authors analyzed data from patients admitted to home care programs collected as part of the Italian Silver Network Home Care project. Twelve home health agencies participated in the project, which evaluated the implementation of the Minimum Data Set for Home Care (MDS-HC) instrument. A total of 2757 patients were enrolled in the current study. The primary outcome measures were the prevalence of 2 or more hours per week of physical activity and survival. RESULTS Fewer than 20% of patients had regular physical activity. During a median follow-up period of 10 months from the initial MDS-HC assessment, 442 (16%) patients died. After adjusting for sex, physical and cognitive disability, and all potential risk factors for death, active patients were less likely to die compared with those with no or very low-intensity physical activity (relative risk ratio [RR], 0.51; 95% confidence interval [CI], 0.35-0.73). This inverse relationship was also significant in patients aged 80 years and older (RR 0.55; 95% CI, 0.32-0.95). CONCLUSIONS Physical activity is associated with a significantly lower risk of all-cause mortality. The current findings support the possibility that moderate-intensity physical activity has an independent effect on survival even among frail and old persons.
Determination of the complete genome and functional analysis of HPV6 isolate VBD19/10 from a patient with aggressive recurrent respiratory papillomatosis

SUMMARY Human papillomavirus (HPV) types 6 and 11 are the aetiological agent of recurrent respiratory papillomatosis (RRP). The complete genome of an HPV6 isolate with a 170 base pair (bp) duplication identified within the long control region (LCR) from a patient with aggressive recurrent respiratory papillomatosis was determined. The promoter sequence from the HPV LCR including the 170 bp duplication was placed upstream of a heterologous reporter gene and the activity of the reporter gene product determined using transfected cells. In total, mutations were observed at 157 nucleotide positions of the complete genome and included nucleotide substitutions, deletions and insertions, resulting in amino acid changes at 43 residue positions. Reporter gene activity using an HPV-derived LCR region with a 170 bp duplication was significantly higher than that using an HPV-derived LCR region with no duplication within this region. The results suggest that novel HPV variants warrant further investigation for potential biomarkers of aggressive disease.
Use and validation of location-based services in urban research: An example with Dutch restaurants

This article focuses on the use of big data for urban geography research. We collect data from the location-based service Foursquare in The Netherlands and employ it to obtain a rich catalogue of restaurant locations and other urban amenities, as well as a measure of their popularity among users. Because the Foursquare data can be combined with traditional sources of socio-economic data obtained from Statistics Netherlands, we can quantify, document and characterise some of the biases inherent in these new sources of data in the context of urban applications. A detailed analysis is given as to when this type of big data is useful and when it is misleading. Although the users of Foursquare are not representative of the whole population, we argue that this inherent bias can be exploited for research about the attractiveness of urban landscapes and consumer amenities in addition to the more traditional data on urban amenities.
Emerging NVM: A Survey on Architectural Integration and Research Challenges

There has been a surge of interest in Non-Volatile Memory (NVM) in recent years. With many advantages, such as density and power consumption, NVM is carving out a place in the memory hierarchy and may eventually change our view of computer architecture. Many NVMs have emerged, such as Magnetoresistive random access memory (MRAM), Phase Change random access memory (PCM), Resistive random access memory (ReRAM), and Ferroelectric random access memory (FeRAM), each with its own peculiar properties and specific challenges. The scientific community has carried out a substantial amount of work on integrating those technologies in the memory hierarchy. As many companies are announcing the imminent mass production of NVMs, we think that it is time to have a step back and discuss the body of literature related to NVM integration. This article surveys state-of-the-art work on integrating NVM into the memory hierarchy. Specially, we introduce the four types of NVM, namely, MRAM, PCM, ReRAM, and FeRAM, and investigate different ways of integrating them into the memory hierarchy from the horizontal or vertical perspectives. Here, horizontal integration means that the new memory is placed at the same level as an existing one, while vertical integration means that the new memory is interleaved between two existing levels. In addition, we describe challenges and opportunities with each NVM technique.
Notes on the Maximum Likelihood Estimation of Haplotype Frequencies

The maximum likelihood estimation (MLE) is one of the most popular ways to estimate haplotype frequencies of a population with genotype data whose linkage phases are unknown. The MLE is commonly implemented in the use of the Expectation‐Maximization (EM) algorithm. It is known that the EM algorithm carries the risk that an estimator may converge erroneously to one of the local maxima or saddle points of the likelihood surface, resulting in serious errors in the MLE of haplotype frequencies. In this note, by theoretical treatments we present the necessary and sufficient conditions that the local maxima or saddle points on the likelihood surface appear. As a rule of thumb, that the difference between the coupling and repulsive haplotype frequencies in phase known individuals is 3/2 times larger than the frequency of phase ambiguous individuals is the sufficient condition that the likelihood surface is unimodal. Moreover, we present the analytic solution to the biallelic two‐locus problem, and construct a general algorithm to obtain the global maximum.