Miracle-dz/UniFAR-FTUs huggingface dataset:
Life-worlds of corporate venturing: a multiple case study on interorganisational knowledge transfer across socio-cultural barriers

Since most innovations occur at the boundaries of cultural systems, the transfer of knowledge across these boundaries is of paramount interest to knowledge management. We investigate how socio-cultural barriers to knowledge transfer emerge from the divergent life-worlds of new ventures and parent corporations and what enables interorganisational knowledge transfer across these barriers. The paper is anchored in the micro-interactionist tradition in organisational learning and addresses the constructivist discourse in social studies of knowledge. The empirical part is based on an exploratory multi-case study on 12 corporate venture capital (CVC) dyads in two different industries in Germany. The results highlight the 'clash of cultures' between parent corporations and new ventures and suggest drawing more attention to the integration of different modes of learning and types of knowledge by boundary-spanning across divergent life-worlds. The CVC units of parent corporations play a crucial role in interorganisational learning both as translator and as broker of knowledge.
Enabling Central Keyword-Based Semantic Extension Search Over Encrypted Outsourced Data

In practice, search keywords have quite different importance when users take search operations. In addition, such keywords may have a certain grammatical relationship among them, which reflect the importance of keywords from the user’s perspective intuitively. However, the existing search techniques regard the search keywords as independent and unrelated. In this paper, for the first time, we take the relation among query keywords into consideration and design a keyword weighting algorithm to show the importance of the distinction among them. By introducing the keyword weight to the search protocol design, the search results will be more in line with the user’s demand. On top of this, we further design a novel central keyword semantic extension ranked scheme. By extending the central query keyword instead of all keywords, our scheme makes a good tradeoff between the search functionality and efficiency. To better express the relevance between queries and files, we further introduce the TF-IDF rule when building trapdoors and the index. In particular, our scheme supports both data set and keywords updates by using the sub-matrix technique. Our work first gives a basic idea for the design of the central keyword semantic extension ranked scheme, and then presents two secure searchable encryption schemes to meet different privacy requirements under two different threat models. Experiments on the real-world data set show that our proposed schemes are efficient, effective, and secure.
Dose Reduction and Image Quality Assessment in 64-Detector Row Computed Tomography of the Coronary Arteries Using an Automatic Exposure Control System

Objective: To evaluate dose reduction and image quality in coronary 64-slice multidetector computed tomography using an automatic exposure control system (AECs). Methods: A total of 101 patients were divided into 4 groups. Tube current was 600 and 800 mAs in groups A and B and adapted at 600 and 800 quality-reference mAs using an AECs in groups C and D. Effective dose and organ-equivalent dose were evaluated. Image noise was quantified as standard deviation of air-space attenuation. Two observers assessed technical adequacy and image quality using a 4-point scale. Results: Effective dose ranged from 8.6 mSv (group C) to 15 mSv (group B) with significant dose reduction for examinations performed at 600 mAs (21.7%) and 800 mAs (29.4%). Contribution of organ-equivalent doses showed higher exposure for lungs (42%) and breast (22%). Noise was significantly higher in groups studied with AECs. Larger coronary segments resulted in higher image quality scores without differences between groups. Conclusion: Automatic exposure control systems provides images of diagnostic quality with substantial dose reduction.
Hypoxia and Serum Deprivation‐Induced Apoptosis in Mesenchymal Stem Cells

In recent years, the understanding that regeneration progresses at the level of the myocardium has placed stem cell research at the center stage in cardiology. Despite an increasing interest in cell transplant research, relatively little is known about the biochemical regulation of the stem cell itself after transplantation into an ischemic heart. We demonstrated here, using rat mesenchymal stem cells (MSCs), that cells undergo caspase‐dependent apoptosis in response to hypoxia and serum deprivation (SD), which are both components of ischemia in vivo. In particular, the treated cells exhibited mitochondrial dysfunction, including cytochrome C release, loss in ΔΨm, and Bax accumulation, but in a p53‐independent manner. Although the cells treated by hypoxia/SD possess the activity of caspase‐8, zIEDT‐fmk, a specific caspase‐8 inhibitor, failed to inhibit cell apoptosis induced in our system. Taken together, our findings indicate that MSCs are sensitive to hypoxia/SD stimuli that involve changes in mitochondrial integrity and function but are potentially independent of caspase‐8.
Estimating Solar Irradiance Using Sky Imagers

Abstract. Ground-based whole-sky cameras are now extensively used for the localized monitoring of clouds. They capture hemispherical images of the sky at regular intervals using a fish-eye lens. In this paper, we propose a framework for estimating solar irradiance from pictures taken by those imagers. Unlike pyranometers, such sky images contain information about cloud coverage and can be used to derive cloud movement. An accurate estimation of solar irradiance using solely those images is thus a first step towards the short-term forecasting of solar energy generation based on cloud movement. We derive and validate our model using pyranometers colocated with our whole-sky imagers. We achieve a better performance in estimating solar irradiance and in particular its short-term variations compared to other related methods using ground-based observations.
Code Synthesis in Self-Improving Software Systems

This extended abstract aims at provoking a wide discussion around code synthesis and its importance in creating the next generation of self-improving software systems. As a starting point for the discussion, a machine-to-machine self-improving framework is presented. The framework aims at improving system's performance by integrating two modules: i) a self-improving online module, and ii) a code synthesiser offline module. The online module learns, at runtime, as it handles the system's inputs, how to best compose the system from a pallet of available software components and a user-defined high level goal. The offline code synthesiser generates new components based on the perceived system's input, executing environment and the system's goal provided by the online module. The code synthesiser then provides better component options for the online module to integrate with the system to improve its performance. This abstract describes the framework, focusing on its main challenges.
Control, Knowledge, and Persuasive Power in Advertising Creativity: An Ethnographic Practice Theory Approach

This article reports findings from an extended multimethod ethnographic study into the social practices of advertising creativity. The study was conducted in a major Iranian creative advertising agency that has many international clients and earns annual billings equivalent to more than USD $100 million. Findings focus on three sets of overlapping, aggregated social practices—labeled control power, knowledge power, and persuasive power—that serve to work around tensions over creative output to accomplish the dual goals of creating good, effective work and persuading the client to buy in to the creative strategy. We conclude with implications for future practice and research.
Development of an international schedule for the assessment and staging of care for dementia.

BACKGROUND A reliable and valid global staging scale has been lacking within dementia care. OBJECTIVE To develop an easy-to-use multi-dimensional clinical staging schedule for dementia. METHODS The schedule was developed through: i) Two series of focus groups (40 and 48 participants, respectively) in Denmark, France, Germany, Netherlands, Spain, Switzerland, and UK with a multi-disciplinary group of professionals working within dementia care, to assess the need for a dementia-staging tool and to obtain suggestions on its design and characteristics; ii) A pilot-study over three rounds to test inter-rater reliability of the newly developed schedule using written case histories, with five members of the project's steering committee and 27 of their colleagues from Netherlands, France, and Spain as participants; and iii) A field-study to test the schedule's inter-rater reliability in clinical practice in France, Germany, Netherlands, Spain, Italy, Turkey, South Korea, Romania, and Serbia, which included 209 dementia patients and 217 of their caregivers as participants. RESULTS Focus group participants indicated a clear need for a culture-fair international dementia staging scale and reached consensus on face validity and content validity. Accordingly, the schedule has been composed of seven dimensions including behavioral, cognitive, physical, functional, social, and care aspects. Overall, the schedule showed adequate face validity, content validity, and inter-rater reliability; in the nine field-sites, intraclass correlation coefficients (ICCs; absolute agreement) for individual dimensions ranged between 0.38 and 1.0, with 84.4% of ICCs over 0.7. ICCs for total sum scores ranged between 0.89 and 0.99 in the nine field-sites. CONCLUSION The IDEAL schedule looks promising as tool for the clinical and social management of people with dementia globally, though further reliability and validity testing is needed.
Analysing the relationship between maternal weight gain and birthweight: exploration of four statistical issues.

Four statistical issues concerning the analysis of birthweight and maternal weight gain during pregnancy are discussed: (1) Part-whole correlation is described (e.g. the correlation between total maternal weight gain and her infant's birthweight). (2) The choice between a ratio or two separate explanatory variables is explored (e.g. body mass index or using maternal weight and height separately). (3) Two statistical properties (bias and power) when a binary variable replaces a continuous variable are discussed (e.g. consequences of using low birthweight instead of reported birthweight). (4) A model selection procedure is presented to provide a way to select a useful subset of variables from a large number of available explanatory variables to model an outcome variable (e.g. birthweight). These issues are illustrated with a set of 4017 births from Moffitt Hospital at the University of California, San Francisco. Furthermore, these four issues arise in a number of applications of statistical methods to data collected to study the epidemiology of newborn infants.
The industrial organisation of economic policy preparation in the Netherlands

In the institutional set-up of (economic) policy preparation in the Netherlands there is ample interaction between scientific insights and policy proposals. This Dutch polder model lays much emphasis on the social dialogue to come to an agreement on, and have public support for policy proposals. It was very much the idea of Jan Tinbergen winner of the first Nobel price in economics to have a clear separation in policy preparation between (i) trying to reach consensus on the working of the economy, as formalised in econometric models; (ii) come to a compromise on policy goals between the various minority parties of the government; and (iii) rely on independent and undisputed data collection by an autonomous Central Bureau of Statistics (CBS). The aim of this separation of responsibilities is to guarantee, as much as possible, the scientific quality of policy preparation and at the same time to gain public support for policy measures so that implementation costs are kept low. This paper discusses the working of this institutional set-up, its historical background and the mechanisms of quality control and reputation which are essential for the interaction between scientific knowledge and policy preparation to remain fruitful.
Disposition Effect and Diminishing Sensitivity: An Analysis Based on a Simulated Experimental Stock Market

ABSTRACT The authors experimentally investigate the existence of the disposition effect and its relationship with diminishing sensitivity. Their approach includes 3 key characteristics: (i) an environment closely resembling actual stock markets, (ii) individual-specific reference prices, and (iii) a direct test of diminishing sensitivity as a correlate of the disposition effect. They find strong support for the existence of the disposition effect as an independent hypothesis. This is an improvement over previous studies, which tested this hypothesis only jointly with others. The authors' results also strongly point to diminishing sensitivity, of the type postulated by prospect theory, being positively associated with the disposition effect.
A Miller divider based clock generator for MBOA-UWB application

A Miller divider based clock generator is proposed for multi-band OFDM alliance (MBOA) ultrawideband (UWB) application. Employing closed-loop operation, the clock generator can produce three difference carrier frequencies with negligible in-band spurs while achieving less than 9.5-ns settling time. A transistor-sizing optimization technique for active inductors with a current-reusing technique is used to achieve low-power operation and area saving. Fabricated in a 0.18-/spl mu/m technology, the clock generator only dissipates less than 22 mW from a 1.8-V power supply.
Neurogenic pulmonary edema after rupture of intracranial aneurysm during endovascular coiling

Neurogenic pulmonary edema (NPE) is a well-known entity, occurs after acute severe insult to the central nervous system. It has been described in relation to different clinical scenario. However, NPE has rarely been mentioned after endovascular coiling of intracranial aneurysms. Here, we report the clinical course of a patient who developed NPE after aneurysmal rupture during endovascular surgery. There was significant cardiovascular instability possibly from stimulation of hypothalamus adjacent to the site of aneurysm. This case highlights the predisposition of minimally invasive procedures like endovascular coiling to life-threatening complications such as NPE.
Lipophilic statin use and suicidal ideation in a sample of adults with mood disorders.

BACKGROUND Mood disorders are associated with a high risk of suicide. Statin therapy has been implicated in this relationship. AIMS To further clarify reported associations between suicide and cholesterol in mental health conditions, we conducted an analysis of dietary, clinical, and suicidal ideation measures in community-living adults with mood disorders. METHOD Data were used from a cross-sectional study of a randomly selected community-based sample (> 18 years; n = 97) with verified mood disorders. Dietary (e.g., fat, iron, vitamin intakes), clinical (e.g., current depression and mania symptoms, medications), and sociodemographic (age, sex, and income) measures were analyzed using bivariate statistics and Poisson regression with robust variance. RESULTS Participants were predominantly female (71.1%) with bipolar disorder (59.8%); almost one-third (28.9%) were taking lipophilic statins. The prevalence of suicidal ideation was more than 2.5 times in those taking statins, PR = 2.59, 95% CI 1.27-5.31, p < . 05. The prevalence ratio for suicidal ideation was 1.10, 95% CI 1.06-1.15, p < . 001, for each unit increase in mania symptom scores. No associations between suicidal ideation and dietary intake measures were identified. CONCLUSION Individuals with mood disorders may be susceptible to neuropsychiatric effects of cholesterol-lowering drugs, which warrants further research.
Monitoring opioid adherence in chronic pain patients: assessment of risk of substance misuse.

BACKGROUND Use of opioids for chronic non-cancer pain (CNCP) has increased in recent years because this pain had been undertreated. There was also a simultaneous increase in misuse and abuse of opioids. Deaths due to such abuse and misuse also have risen as seen in the many reports published every day in local papers as well as in the medical literature. So, it is imperative that patients who are prescribed these medications be monitored for adherence so misuse and abuse can be curtailed and opioids are available to those who genuinely need them for chronic pain control. There are various screening tools available to monitor such adherence, and there is an abundance of literature about it in addiction and psychiatric medicine. There is, though, a paucity of such literature as applied to pain medicine. OBJECTIVES Our objectives for this review were twofold. We wanted to identify which screening tools are available to monitor opioid adherence and we wanted to see if there were prospective comparative studies of these tools to identify a single best tool that can be applied to all chronic non-cancer pain patients managed with opioids. STUDY DESIGN We did a review of the current literature about monitoring of opioid adherence. We also looked at their use, validity, and comparative studies. METHODS We performed a literature search using PubMed, EMBASE, and the Cochrane library. The search was conducted using the terms opioids, non-cancer pain, monitoring, and adherence. The databases from 1996 to November 2010 were reviewed. The search included prospective and retrospective studies, review articles, and FDA records. Bibliographies and cross references were reviewed when deemed appropriate. CONCLUSION We found 52 publications, of which 22 met the criteria to be included in this manuscript. We found only one study that was prospective, and compared the various screening tools that are available to monitor opioid adherence. In the majority of the studies the number treated was small. There was not a single screening tool that can be applied universally to all patients who are on opioid therapy for chronic non-cancer pain.
Managerial Indemnification and Liability Insurance: The Effect on Shareholder Wealth

Possible manager-shareholder conflicts have increased the debate over the role of indemnification and directors' and officers' (D&O) liability insurance. Arguing that such insurance has adverse incentive effects which harm shareholders, some have recommended regulations to limit such practices. We provide empirical evidence on the effect of D&O insurance on shareholder wealth. To the extent such insurance affects shareholder wealth, it appears to increase it. Broadening of indemnification and the passage in 1941 of a New York law that was the first to authorize corporate indemnification have no significant shareholder wealth effects. These findings suggest no compelling reason for adopting regulations to limit D&O insurance.
Intervening to Improve Compassion Fatigue Resiliency in Forensic Nurses

Evidence suggests that forensic nurses (FNs) may be predisposed to compassion fatigue (CF) as a result of the challenges of the profession including high caseloads, role ambiguity, prosecution goals, vicarious traumatization, attending to survivors' emotional needs, and empowering victims. The purpose of this exploratory study was to determine the prevalence of CF in a convenience sample of 55 FNs and examine the treatment effectiveness of a multifaceted education program in an intervention subset. The intervention was intended to increase compassion satisfaction (CS) and decrease CF symptoms in FNs in one organization who participated in the training. The hypothesis was that the FNs will have moderate to high CF and moderate to high CS and the CF intervention will add in CF prevention and resiliency as measured with an improvement in the Professional Quality of Life test scores (B. H. Stamm, 2010a). In the prevalence sample, 69% of the FNs had moderate to low CS, 73% had moderate to high burnout, and 73% had moderate to high levels of secondary traumatic stress (STS). In the intervention group, the education program resulted in a statistically significant increase in CS and decreases in STS symptoms.
Bcr‐Abl oncoproteins bind directly to activators of the Ras signalling pathway.

The cytosolic 185 and 210 kDa Bcr‐Abl protein tyrosine kinases play important roles in the development of Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (Ph+ ALL). p185 and p210 Bcr‐Abl contain identical abl‐encoded sequences juxtaposed to a variable number of bcr‐derived amino acids. As the mitogenic and transforming activities of tyrosine kinases involve stimulation of the Ras pathway, we analyzed Bcr‐Abl oncoproteins for interactions with cytoplasmic proteins that mediate Ras activation. Such polypeptides include Grb2, which comprises a single Src homology 2 (SH2) domain flanked by two SH3 domains, and the 66, 52 and 46 kDa Shc proteins which possess an SH2 domain in their carboxy‐terminus. Grb2 associates with tyrosine phosphorylated proteins through its SH2 domain, and with the Ras guanine nucleotide releasing protein mSos1 through its SH3 domains. mSos1 stimulates conversion of the inactive GDP‐bound form of Ras to the active GTP‐bound state. In bcr‐abl‐transformed cells, Grb2 and mSos1 formed a physical complex with Bcr‐Abl. In vitro, the Grb2 SH2 domain bound Bcr‐Abl through recognition of a tyrosine phosphorylation site within the amino‐terminal bcr‐encoded sequence (p.Tyr177‐Val‐Asn‐Val), that is common to both Bcr‐Abl proteins. These results suggest that autophosphorylation within the Bcr element of Bcr‐Abl creates a direct physical link to Grb2‐mSos1, and potentially to the Ras pathway, and thereby modifies the target specificity of the Abl tyrosine kinase. (ABSTRACT TRUNCATED AT 250 WORDS)
How Do Agents React to Dynamic Wage Increases? An Experimental Study

We investigate how workers' performance is affected by the timing of wages in a real-effort experiment. In all treatments agents earn the same wage sum but wage increases are distributed differently over time. We find that agents work harder under increasing wage profiles if they do not know these profiles in advance. A profile that continuously increases wages by small amounts raises performance by about 15% relative to a constant wage. The effort reactions can be organized by a model in which agents reciprocally respond to wage impulses, comparing wages to an adaptive reference standard determined by the previous wage.
Different morphology of amyloid fibrils originating from agitated and non-agitated conditions

Abstract In vitro amyloid formation has been suggested to be a common property of any polypeptide chain depending on particular environmental conditions although in vivo amyloid fibril formation can be promoted by point mutations or triplet expansions. Here, we explored the influence of agitation on fibril formation of amyloidogenic alanine segments fused to Cold Shock Protein B (CspB) of Bacillus subtilis. While without agitation fibril formation was clearly dependent on the presence of an amyloidogenic alanine segment, fibril formation was independent of the amyloidogenic segment under agitation. Agitation even led to fibrillation of native CspB lacking the amyloidogenic segment. Furthermore, agitation not only influenced the kinetics of fibril formation, but also resulted in completely different fibril morphologies. These results indicate that experimental conditions can alter the region that undergoes a conformational change during in vitro fibrillation. Moreover, the data show that deductions from in vitro assays on in vivo fibril formation mechanisms are afflicted with a certain degree of uncertainty and therefore need to be cautiously discussed.