Miracle-dz/UniFAR-FTUs huggingface dataset:
Circulating Bone Marrow Cells Can Contribute to Neointimal Formation

To examine the source of smooth muscle-like cells during vascular healing, C57BL/6 (Ly 5.2) female mice underwent whole body irradiation followed by transfusion with 106 nucleated bone marrow cells from congenic (Ly 5.1) male donors. Successful repopulation (88.4 ± 4.9%) by donor marrow was demonstrated in the female mice by flow cytometry with FITC-conjugated A20.1/Ly 5.1 monoclonal antibody after 4 weeks. The arteries of the female mice were then subjected to two types of insult: (1) The iliac artery was scratch-injured by 5 passes of a probe causing severe medial damage. After 4 weeks, the arterial lumen was obliterated by a cell-rich neointima, with cells containing α smooth muscle actin present around the residual lumen. Approximately half of these cells were of male donor origin, as evidenced by in situ hybridization with a Y-chromosome-specific probe. (2) In an organized arterial thrombus formed by inserting an 8-0 silk suture into the left common carotid artery, donor cells staining with α smooth muscle actin were found in those arteries sustaining serious damage but not in arteries with minimal damage. Our results suggest that bone marrow-derived cells are recruited in vascular healing as a complementary source of smooth muscle-like cells when the media is severely damaged and few resident smooth muscle cells are available to effect repair.
STATIC CODE ANALYSIS FOR SOFTWARE QUALITY IMPROVEMENT: A CASE STUDY IN BCI FRAMEWORK DEVELOPMENT

This paper shows how the systematic approach in software testing using static code analysis method can be used for improving the software quality of a BCI framework. The method is best performed during the development phase of framework programs. In the proposed approach, we evaluate several software metrics which are based on the principles of object oriented design. Since such method is depending on the underlying programming language, we describe the method in term of C++ language programming whereas the Qt platform is also currently being used. One of the most important metric is so called software complexity. Applying the software complexity calculation using both McCabe and Halstead method for the BCI framework which consists of two important types of BCI, those are SSVEP and P300, we found that there are two classes in the framework which have very complex and prone to violation of cohesion principle in OOP. The other metrics are fit the criteria of the proposed framework aspects, such as: MPC is less than 20; average complexity is around value of 5; and the maximum depth is below 10 blocks. Such variables are considered very important when further developing the BCI framework in the future.
Flying head: head-synchronized unmanned aerial vehicle control for flying telepresence

We propose an unmanned aerial vehicle (UAV) control mechanism, called a "Flying Head", which synchronizes human head and robot motions. Previous telepresence research has centered on the use of robots that move along the ground using wheels or legs. Recently, however, telepresence research has expanded to include the use of remote flying robots. The accurate manipulation of such robots, is difficult, however, as their control typically involves hand-operated devices such as proportional R/C systems or joysticks. Using the Flying Head system, we can incorporate a robot control using human motions such as walking, looking around and crouching. Our system synchronizes the operator and UAV positions in terms of the horizontal and vertical positions and the yaw orientation. The operator can use the UAV more intuitively, as such manipulations are more in accord with kinesthetic imagery. We will develop additional flying telepresence applications, such as capturing platforms, teleoperation, sports training, and healthcare.
Outcomes in Nonagenarians after Hemiarthroplasty for Femoral Neck Fracture. A Prospective Matched Cohort Study

A prospective cohort of 33 nonagenarians with hemiartroplasty for femoral neck fracture was matched with 33 patients aged between 70 and 89, using preoperative and postoperative data, and the following were studied; epidemiological data, physical dependence, and SF-12 and WOMAC questionnaires. The mortality rate at one year was 24.2%, influenced by the presence of 3 or more comorbidities, dementia, and previous dependence. The perioperative period was the most vulnerable time, and in some cases delaying surgery should be considered to stabilise the patient's medical condition in very elderly patients. Mortality and functional outcomes were worse than in younger patients, but the surgical complication rate was similar. Prognostic factors for a decline in quality of life were dementia and previous dependence.
Variety and complexity of chromosome 17 translocations in neuroblastoma

In neuroblastoma, the most frequent genetic alteration is gain of chromosome arm 17q, which arises from unbalanced translocations. To document these genetic events more precisely, we performed an extensive study of chromosome 17 breakpoints in 27 neuroblastoma cell lines by using a combination of fluorescence in situ hybridization mapping with BAC/PAC clones and allele analysis with polymorphic markers. All cases exhibited one or more unbalanced chromosome 17 translocations, and 15 distinct breakpoint regions could be mapped. This high variability indicates that gene fusion or disruption events are extremely unlikely to account for the underlying oncogenic role of these translocations. However, breakpoints were not randomly distributed, most of them mapping to the proximal part of 17q. As a result of translocations, all cell lines but one exhibited gain of the 53.5 Mb→qter fragment, bordered proximally by the clone CTC‐462L7. The most telomeric breakpoint, flanked by the clone RP11‐443M10, defined the 70.9 Mb→qter fragment as a region of additional gain. In addition to chromosome gains, loss of heterozygosity for the short arm of chromosome 17 was observed in close to half the cases. It was either related to a chromosome 17 monosomy or to a uniparental isodisomy. Finally, in cases with a single normal chromosome 17, we show that the parental origin of the translocated chromosome 17 can be either distinct or identical to that of the normal chromosome. Similarly, multiple translocations within the same cell line can either involve the same or different chromosome 17 homologues, indicating the likely absence of parental origin bias in the generation of these alterations. © 2003 Wiley‐Liss, Inc.
Specific order impairment in arabic number writing: A case‐study

The present study examines the transitory deficit in transcoding verbal to Arabic numbers in an aphasic patient, TM. She showed a mild syntactic impairment in syntactic comprehension of verbal numbers, with preserved performance in comprehension of Arabic numbers, in access to semantic representation, as well as in reading of Arabic numbers, but she committed 75% of errors when required to write numbers in the Arabic format to dictation. In conformity to the previous literature on transcoding deficits, the majority of her errors were syntactic (60%). However, most of them were unusual “order errors” (50%) in which lexical digits (e.g., 1 to 9) were written on the left and zeros on the right of the number, which contained in the majority of the cases the correct number of digits. A similar type of errors has been reported in only one previous case study (Delazer & Denes, 1998), but not specifically studied. We discuss hypotheses concerning its origins as stemming from a syntactic disorder within existing models of transcoding (McCloskey, Caramazza, & Basili, 1985; Power & Dal Martello, 1990). We also report kinematic assessment of the patient's handwriting before and after recovery. At time of the second examination, results show that her pattern of movement fluency parallels that of healthy subjects and supports a distinction between two types of zeros within Arabic numbers, in relation to the verbal code and the rules required to produce them. This paper thus also highlights the potential usefulness of using a digitising tablet in the study of transcoding deficits.
Using stable isotopes to resolve transit times and travel routes of river water: a case study from southern Finland†

ABSTRACT The stable isotopic composition of two rivers, the Vantaanjoki River and the Kokemäenjoki River, in southern and southwestern Finland was studied to resolve the transit times and travel routes of the river water in the two different catchments. The Kokemäenjoki River is dominated by great lake basins whereas the Vantaanjoki River has been reported having a significant groundwater component. The mean residence time of the young surface flow component could be resolved by sine function fitting onto the annual fluctuations of the isotopic signal, and the amount of base flow was estimated by using the isotopic composition of the river and groundwater. In this study, we found that the methods work for simple two component catchments. In more complex cases with three different components mixing, the solution becomes increasingly difficult and requires more study.
Lack of an endogenous GABAA receptor‐mediated tonic current in hypoglossal motoneurons

• Tonic GABAA receptor‐mediated currents have profound effects on neuronal excitability, yet it is not known whether this current is present in mammalian motoneurons. • This study shows that tonic GABAA receptor‐mediated current can be observed in hypoglossal motoneurons in vitro under certain experimental conditions. • The tonic current was only observed when exogenous GABA was applied and GABA transporters were blocked suggesting that GABA transporters highly regulate extracellular GABA concentration. • Furthermore, we demonstrate that the current probably arises from activation of extrasynaptic GABAA receptors containing a δ subunit. • This tonic current may function to reduce the excitability of hypoglossal motoneurons; these motoneurons are important in many functions including chewing, swallowing, suckling, vocalization and upper airway patency.
Use of Socioscientific Contexts for Promoting Student Agency in Environmental Science Classrooms

Bu calisma sosyobilimsel odakli bir cevre bilimi dersinin ogrencilerin failliginin arttirilmasi hedeflenerek yapilandirilmasini incelemektedir. Ogrenci failligi (eylemliligi) bu calisma kapsaminda ogrencilerin ilgileri dogrultusunda bilincli eylemler gerceklestirmesi ya da bireylerin bir sonraki asamada ne olacagini secme yetisi olarak tanimlanmistir. Calismanin katilimcilarini 31 lise ogrencisi ve cevre bilimi dersini birlikte ogreten bir fen bilgisi ve bir sosyal bilgiler ogretmeni olusturmaktadir. Ic ice gecmis tek durum deseninin kullanildigi bu calismada toplanan veriler sinif-ici gozlemler, yari-yapilandirilmis gorusmeler ve katilimci ogretmen ve ogrencilerle sinif ortaminda gerceklesen dogal konusmalardan olusmaktadir. Nitel verilerin analizi ise sirasiyla acik kodlama ve icerik analizi yontemleriyle gerceklestirilmistir. Bu calismanin bulgulari ogretmenlerin sosyobilimsel konularin cok yonlu ve disiplinlerarasi dogasini kullanarak ogrencilerini, kisisel ilgilerine gore sectikleri yollarda ilerlemeleri noktasinda cesaretlendirdiklerini gostermektedir. Bunun sonucunda ogrencilerin cevre kalitesini arttirmayi hedefleyen projeler yoluyla yasadiklari toplumda fark yaratmak noktasinda daha motive ve cesaretli olduklari gorulmustur
User experiences on location-aware mobile services

This paper describes the user experiences gained from the use of a location sensitive mobile services in urban environment, collected with a diary study and user interviews over one summer. In this study users' perceived problems and the resulting frustration and difficulties in use were mainly caused by slow or unreliable data connections and lack of content in mobile services. On the other hand, users identified the future potential of these mobile services.
OSTBC Transmission in Large MIMO Systems

Abstract—We address the problem of orthogonal space-time block code (OSTBC) transmission in a large multiple-input multiple-output (MIMO) system in Rayleigh fading environment. Because of the fact that there are hundreds of antennas at the transmitter, a very large dimension OSTBC is required in the case of massive MIMO system. Full rate OSTBC is available only for two transmit antenna-based system with complex symbols. Recently, an implementation of OSTBC for 32 transmit and 32 receive antennas is presented for real symbols. In this letter, we present a scheme of OSTBC transmission for practical large MIMO systems by embedding OSTBCs of small dimensions with good rate. At the receiving end, the decoding of OSTBCs is performed by utilizing the concept of null space. It is shown by simulation and analysis that the code rate can be improved at the cost of degraded performance; however, the performance of large MIMO system is not an issue because of the availability of very large antennas at the transmitter and receiver. The expression for the moment generating function (MGF) of the received signalto-noise ratio at the receiver node is derived for the proposed OSTBC-based scheme. Using the MGF expression, we obtain the analytical symbol error rate for the proposed scheme withM -ary phase-shift keying modulation symbols.
Hepatic gene expression analysis of mice exposed to raw water from Meiliang Bay, Lake Taihu, China

Lake water is a micro‐polluted water system, and characterization of its toxicity remains difficult. Microarray‐based determination of altered gene expression might be an alterative approach. We chose raw water from Meiliang Bay, Lake Taihu, China as the target water. Male mice were exposed to the lake water for 90 days. Total hepatic RNA was applied to interrogate the Affymetrix Mouse Genome 430A 2.0 array. Gene ontology analysis, pathway analysis and gene network analysis were used to identify biological effects of differently expressed genes. The results showed that the expressions of 170 genes were altered. Nine biological processes and nine biological pathways were significantly perturbed (P ≤ 0.01), mainly linked to the regulation of cell processes, DNA repair, chromatin modification, oxidative reduction and carbohydrate metabolism. Important genes, such as Prkca, Pik3r1, Fgfr1 and Zbtb16, were identified by gene network analysis. This study provided excellent insights into early toxicological effects related to raw Lake Taihu water, and illustrated that the toxicogenomic approach might be a useful tool to evaluate potential environmental health effects of raw lake water. Copyright © 2012 John Wiley & Sons, Ltd.
Exploring the reasons for student ethnic groupings: The case of Chinese students at the University of Windsor (Ontario).

This study was designed to explore the reasons of the common phenomenon that Mainland Chinese international students on a Canadian university campus are always seen staying within their own culturally homogenous circles with very limited communication with other students from different cultural backgrounds. A qualitative research approach was employed to ascertain the reasons for this phenomenon. Ten Chinese international students from Mainland China studying at the University of Windsor participated in this study. They were interviewed in Mandarin individually over a period of seven weeks, each interview being taped, translated and transcribed. The findings derived from this study include language difficulties, cultural divergence, evaluation criteria, understanding of institutional administration and corresponding response, and the inertia of dependence on compatriot groups. This study adds to existing literature on Chinese international students’ sojourn experiences on Canadian university campuses. A portion of the findings of this study lends support to the findings of some previous research on the sojourn life of Chinese international students in Canada. A considerable portion of the findings, however, disputes the conclusions of some existing research on related issues. Some unexpected themes were also generalized through data analysis. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
Patterns of alcohol consumption and the metabolic syndrome.

CONTEXT AND OBJECTIVE Protective and detrimental associations have been reported between alcohol consumption and the metabolic syndrome. This may be due to variations in drinking patterns and different alcohol effects on the metabolic syndrome components. This study is designed to examine the relationship between alcohol consumption patterns and the metabolic syndrome. DESIGN, SETTING, PARTICIPANTS, AND MEASURES The 1999-2002 National Health and Nutrition Examination Survey is a population-based survey of noninstitutionalized U.S. adults. Current drinkers aged 20-84 yr without cardiovascular disease who had complete data on the metabolic syndrome and drinking patterns were included in the analysis (n = 1529). The metabolic abnormalities comprising the metabolic syndrome included having three of the following: impaired fasting glucose/diabetes mellitus, high triglycerides, abdominal obesity, high blood pressure, and low high-density-lipoprotein cholesterol. Measures of alcohol consumption included usual quantity consumed, drinking frequency, and frequency of binge drinking. RESULTS In multinomial logistic regression models controlling for demographics, family history of cardiovascular disease and diabetes, and lifestyle factors, increased risk of the metabolic syndrome was associated with daily consumption that exceeded U.S. dietary guideline recommendations (more than one drink per drinking day for women and more than two drinks per drinking day for men (odds ratio 1.60, 95% confidence interval 1.22-2.11) and binge drinking once per week or more [odds ratio (95% confidence interval) 1.51 (1.01-2.29]. By individual metabolic abnormality, drinking in excess of the dietary guidelines was associated with an increased risk of impaired fasting glucose/diabetes mellitus, hypertriglyceridemia, abdominal obesity, and high blood pressure. CONCLUSION Public health messages should emphasize the potential cardiometabolic risk associated with drinking in excess of national guidelines and binge drinking.
Cointegration and Causality Between Exports and Economic Growth in Xinjiang Region

This paper investigates the interrelation between the economic growth and exports by using coin- tegration test and Granger Causality test based on error correction model in Xinjiang region over the period 1980 -2003. The results show that there is only one cointegration relationship between the economic growth and ex- ports,and they have dual Granger Causality relationships.
Real‐time imaging of actin filaments in the zebrafish oocyte and embryo

Dynamic changes of cytoplasmic and cortical actin filaments drive various cellular and developmental processes. Although real‐time imaging of actin filaments in living cells has been developed, imaging of actin filaments in specific cells of living organisms remains limited, particularly for the analysis of gamete formation and early embryonic development. Here, we report the production of transgenic zebrafish expressing the C‐terminus of Moesin, an actin filament‐binding protein, fused with green fluorescent protein or red fluorescent protein (GFP/RFP‐MoeC), under the control of a cyclin B1 promoter. GFP/RFP‐MoeC was expressed maternally, which labels the cortical actin cytoskeleton of blastula‐stage cells. High levels of GFP/RFP fluorescence were detected in the adult ovary and testis. In the ovaries, GFP/RFP‐MoeC was expressed in oocytes but not in follicle cells, which allows us to clearly visualize the organization of actin filaments in different stages of the oocyte. Using full‐grown oocytes, we revealed the dynamic changes of actin columns assembled in the cortical cytoplasm during oocyte maturation. The number of columns slightly decreased in the early period before germinal vesicle breakdown (GVBD) and then significantly decreased at GVBD, followed by recovery after GVBD. Our transgenic fish are useful for analyzing the dynamics of actin filaments in oogenesis and early embryogenesis. © 2015 Wiley Periodicals, Inc.
Improving Messaging Security in Structured P2P Overlay Networks

Peer-to-peer networking technologies are gaining increasing popularity for file sharing and media streaming applications. To support these set of applications, structured peer-to-peer (P2P) overlay networks may be employed to provide an overlay substrate. In structured P2P overlay networks, peer nodes, content objects and messages are often identified using a set of well defined identifications (Ids.) Objects are stored on peer nodes based on a set of predefined rules. Messages are routed towards the destination node, for example, the root node of the message Id, after an average of h routing hops. In the absence of faults, a high probability of successful message forwarding, i.e., a message is delivered correctly to the destination node, can be achieved even when a large fraction of the peer nodes crash. However, most current overlay networks are not secure. When one or more malicious nodes are presented in the overlay, they can prevent correct message delivery throughout the overlay. This paper studies attacks aimed at preventing correct message delivery in structured peer-to-peer overlays. Several different routing algorithms are analyzed to understand means to improve messaging security without significant additional cost.
ABA transport factors found in Arabidopsis ABC transporters

Abscisic acid (ABA) is a phytohormone that plays an important role in responses to environmental stresses as well as seed maturation and germination. Intracellular signaling by ABA has been rigorously investigated in relation to stomatal guard-cell regulation, seed germination, and abiotic stress responses. However, intercellular regulation of ABA, including the molecular basis of ABA transport systems, has hardly been examined in any plant species. Based on genetic and biochemical analyses, we present evidence that one of the ATP-binding cassette (ABC) transporter genes, AtABCG25, encodes a protein that functions as an ABA exporter through the plasma membrane and is involved in the intercellular ABA signaling pathway. The ABC-type transporter is conserved in model species from E. coli to humans and is reported to transport various metabolites or signaling molecules in an ATP-dependent manner. At same time, another ABC transporter in Arabidopsis, AtABCG40, was independently reported to function as an ABA importer in plant cells. These findings strongly suggest the active control of ABA transport between plant cells, and they provide a novel impetus for examining ABA intercellular regulation.