Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non‐Hodgkin lymphoma

We conducted a population‐based case‐control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes may modify the association between blood transfusion and risk of non‐Hodgkin lymphoma (NHL). Compared with women without blood transfusion, women with a history of transfusion had an increased risk of NHL if they carried IL10RA (rs9610) GG genotype [odds ratio (OR) = 1.9, 95% confidence interval (CI): 1.1–3.2] or TNF (rs1800629) AG/AA genotypes (OR = 1.6, 95% CI: 0.9–2.7). We also found women with a history of transfusion had a decreased risk of NHL if they carried IL10RA (rs9610) AG/AA genotypes (OR = 0.6, 95% CI: 0.4–0.9) or TNF (rs1800629) GG genotype (OR = 0.7, 95% CI: 0.5–1.0). A similar pattern was also observed for B‐cell lymphoma but not for T‐cell lymphoma. Statistically significant interactions with blood transfusion were observed for IL10RA (rs9610) (Pforinteraction = 0.003) and TNF (rs1800629) (Pforinteraction = 0.012) for NHL overall and IL10RA (rs9610) (Pforinteraction = 0.001) and TNF (rs1800629) (Pforinteraction = 0.019) for B‐cell lymphoma. The results suggest that genetic polymorphisms in TNF and IL10RA genes may modify the association between blood transfusion and NHL risk. Am. J. Hematol. 2012. © 2012 Wiley Periodicals, Inc.
Off-season training habits and preseason functional test measures of division iii collegiate athletes: a descriptive report.

PURPOSE/BACKGROUND Division III (D III) collegiate coaches are challenged to assess athletic readiness and condition their athletes during the preseason. However, there are few reports on off-season training habits and normative data of functional assessment tests among D III athletes. The purpose of this study was to examine off-season training habits of D III athletes and their relationships to the standing long jump (SLJ) and single-leg hop (SLH) tests. METHODS One-hundred and ninety-three athletes (110 females, age 19.1 ± 1.1 y; 83 males, age 19.5 ± 1.3 y) were tested prior to the start of their sports seasons. Athletes reported their off-season training habits (weightlifting, cardiovascular exercise, plyometric exercise, and scrimmage) during the six weeks prior to the preseason. Athletes also performed three maximal effort SLJs and three SLHs. RESULTS Male athletes reported training more hours per exercise category than their female counterparts. Mean SLJ distances (normalized to height) were 0.79 ± 0.10 for females and 0.94 ± 0.12 for males. Mean SLH distances for female athletes' right and left limbs were 0.66 (± 0.10) and 0.65 (± 0.10), respectively. Mean SLH distances for male athletes' right and left limbs were 0.75 (± 0.13) and 0.75 (± 0.12), respectively. Several significant differences between off-season training habits and functional test measures were found for both sexes: males [SLJ and weightlifting (p = 0.04); SLH and weightlifting (p = 0.04), plyometrics (p = 0.05)]; females [SLJ and plyometrics (p = 0.04); SLH and scrimmage (p = 0.02)]. CONCLUSION This study provides normative data for off-season training habits and preseason functional test measures in a D III athlete population. Greater SLJ and SLH measures were associated with increased time during off-season training. CLINICAL RELEVANCE The findings between functional tests and off-season training activities may be useful for sports medicine professionals and strength coaches when designing their preseason training programs. LEVEL OF EVIDENCE 4.
Monitoring Urban Sprawl Using Remote Sensing and GIS Techniques of a Fast Growing Urban Centre, India

India's urban population has grown tremendously in the last four decades from 79 million in 1961 to 285 million in 2001. This fast rate of increase in urban population is mainly due to large scale migration of people from rural and smaller towns to bigger cities in search of better employment opportunities and good life style. This rapid population pressure has resulted in unplanned growth in the urban areas to accommodate these migrant people which in turn leads to urban sprawl. It is a growing problematic aspect of metropolitan and bigger city's growth and development in recent years in India. Urban sprawl has resulted in loss of productive agricultural lands, open green spaces, loss of surface water bodies and depletion of ground water. Therefore, there is a need to study, understand and quantify the urban sprawl. In this paper an attempt has been made to use Shannon's entropy model to assess urban sprawl using IRS P-6 data and topographic sheet in GIS environment for one of the fastest growing city of South India and its surrounding area. The built-up area of the city has increased from 135 km2 in 1971 to 370 km2 in 2005. The study shows that there is a remarkable urban sprawl in and around the twin city between 1971 and 2005 because 215 km2 of agricultural land has lost to built-up land during this period. As a result the urban ecosystem has changed in the last four decades.
Evaluation of air quality zone classification methods based on ambient air concentration exposure

ABSTRACT Air quality zones are used by regulatory authorities to implement ambient air standards in order to protect human health. Air quality measurements at discrete air monitoring stations are critical tools to determine whether an air quality zone complies with local air quality standards or is noncompliant. This study presents a novel approach for evaluation of air quality zone classification methods by breaking the concentration distribution of a pollutant measured at an air monitoring station into compliance and exceedance probability density functions (PDFs) and then using Monte Carlo analysis with the Central Limit Theorem to estimate long-term exposure. The purpose of this paper is to compare the risk associated with selecting one ambient air classification approach over another by testing the possible exposure an individual living within a zone may face. The chronic daily intake (CDI) is utilized to compare different pollutant exposures over the classification duration of 3 years between two classification methods. Historical data collected from air monitoring stations in Kuwait are used to build representative models of 1-hr NO2 and 8-hr O3 within a zone that meets the compliance requirements of each method. The first method, the “3 Strike” method, is a conservative approach based on a winner-take-all approach common with most compliance classification methods, while the second, the 99% Rule method, allows for more robust analyses and incorporates long-term trends. A Monte Carlo analysis is used to model the CDI for each pollutant and each method with the zone at a single station and with multiple stations. The model assumes that the zone is already in compliance with air quality standards over the 3 years under the different classification methodologies. The model shows that while the CDI of the two methods differs by 2.7% over the exposure period for the single station case, the large number of samples taken over the duration period impacts the sensitivity of the statistical tests, causing the null hypothesis to fail. Local air quality managers can use either methodology to classify the compliance of an air zone, but must accept that the 99% Rule method may cause exposures that are statistically more significant than the 3 Strike method. Implications: A novel method using the Central Limit Theorem and Monte Carlo analysis is used to directly compare different air standard compliance classification methods by estimating the chronic daily intake of pollutants. This method allows air quality managers to rapidly see how individual classification methods may impact individual population groups, as well as to evaluate different pollutants based on dosage and exposure when complete health impacts are not known.
Glutathione S-transferase M1 and T1 gene polymorphisms and risk of hypertension in tea garden workers of North-East India.

AIMS Polymorphisms of genes encoding phase II metabolic enzymes, for example, glutathione S-transferase, have been linked with hypertension. The present study aimed at finding out the association between GSTM1 and GSTT1 polymorphism and hypertension in a population from North-East India. MATERIALS AND METHODS We carried out a case-control study in tea garden workers of Assam. A total of 223 hypertensive cases and 236 normotensive control subjects were recruited with a record of socio-demographic information, blood pressure, and anthropometric data. Fasting venous blood samples from all subjects were obtained and subjected to DNA extraction and polymerase chain reaction to detect polymorphism of the GSTM1 and GSTT1 genes. RESULTS The null genotype was prevalent in 38.1% and 28.1% of the study participants (cases and controls) for GSTM1 and GSTT1 genes, respectively. Hypertensive subjects had a significantly higher prevalence of the GSTM1 null genotype (43% vs. 33.5%, than normotensive control subjects, p=0.035). Association between the GSTM1 null genotype and hypertension was significant in younger subjects. Tobacco users with the GSTT1 null genotype were at an increased risk for hypertension. CONCLUSION The knowledge of GSTM1 and GSTT1 variant status will be useful to predict the risk of hypertension in a population.
A Tool to Diagnose Autism in Children Aged Between Two to Five Old: An Exploratory Study with the Robot QueBall

QueBall is a spherical robot capable of motion and equipped with touch sensors, multi-colored lights, sounds, and a wireless interface with an iOS device. While these capabilities may be useful in assisting the early diagnosis of autism, no detailed guidelines have yet been established to achieve this. In this report, we described the exploratory study conducted with an interdisciplinary research team to adapt QueBall's capabilities in order to have clinicians observe how children interact with QueBall. This is the preliminary phase in designing an experimental protocol to evaluate the use of QueBall in diagnosing autism for children from two to five years of age.
Next-generation sequencing analysis of lager brewing yeast strains reveals the evolutionary history of interspecies hybridization

The lager beer yeast Saccharomyces pastorianus is considered an allopolyploid hybrid species between S. cerevisiae and S. eubayanus. Many S. pastorianus strains have been isolated and classified into two groups according to geographical origin, but this classification remains controversial. Hybridization analyses and partial PCR-based sequence data have indicated a separate origin of these two groups, whereas a recent intertranslocation analysis suggested a single origin. To clarify the evolutionary history of this species, we analysed 10 S. pastorianus strains and the S. eubayanus type strain as a likely parent by Illumina next-generation sequencing. In addition to assembling the genomes of five of the strains, we obtained information on interchromosomal translocation, ploidy, and single-nucleotide variants (SNVs). Collectively, these results indicated that the two groups of strains share S. cerevisiae haploid chromosomes. We therefore conclude that both groups of S. pastorianus strains share at least one interspecific hybridization event and originated from a common parental species and that differences in ploidy and SNVs between the groups can be explained by chromosomal deletion or loss of heterozygosity.
Maternal methadone dosing schedule and fetal neurobehaviour

Objective. Daily methadone maintenance is the standard of care for opiate dependency during pregnancy. Previous research has indicated that single-dose maternal methadone administration significantly suppresses fetal neurobehaviours. The purpose of this study was to determine if split-dosing would have less impact on fetal neurobehaviour than single-dose administration. Methods. Forty methadone-maintained women were evaluated at peak and trough maternal methadone levels on single- and split-dosing schedules. Monitoring sessions occurred at 36- and 37-weeks gestation in a counterbalanced study design. Fetal measures included heart rate, variability, accelerations, motor activity and fetal movement-heart rate coupling (FM-FHR). Maternal measures included heart period, variability, skin conductance, respiration and vagal tone. Repeated measure analysis of variance was used to evaluate within-subject changes between split- and single-dosing regimens. Results. All fetal neurobehavioural parameters were suppressed by maternal methadone administration, regardless of dosing regimen. Fetal parameters at peak were significantly lower during single versus split methadone administration. FM-FHR coupling was less suppressed from trough to peak during split-dosing versus single-dosing. Maternal physiologic parameters were generally unaffected by dosing condition. Conclusion. Split-dosed fetuses displayed less neurobehavioural suppression from trough to peak maternal methadone levels as compared with single-dosed fetuses. Split-dosing may be beneficial for methadone-maintained pregnant women.
The contribution of attachment security and social support to depressive symptoms in patients with metastatic cancer

The present study examines the association between disease‐related factors, perceived social support, attachment security (i.e. attachment anxiety and avoidance), and the occurrence of depressive symptoms in a sample of patients with metastatic gastrointestinal or lung cancer. Results from a sample of 326 cancer outpatients with advanced disease indicate that disease‐related factors are significantly associated with the occurrence of depressive symptoms, and the latter are inversely related to the degree of attachment anxiety and avoidance, and perceived social support. Attachment security (on the dimension of anxious attachment) significantly buffered the effect of disease‐related factors on depressive symptoms, and perceived social support mediated the relationship between attachment security and depressive symptoms. The buffering effect of attachment security on depressive symptoms and its partial mediation through social support suggest that the interaction of individual, social, and disease‐related factors contribute to the emergence of depressive symptoms in patients with metastatic cancer. Copyright © 2007 John Wiley & Sons, Ltd.
Neuroendocrine-immune system in patients with rheumatoid arthritis

The neuroendocrine-immune system plays an important role in maintaining homeostasis. Since patients with rheumatoid arthritis (RA) tend to be exposed to long-term physical and psychological stress during the course of the disease, it is hypothesized that their neuroendocrine-immune system will become dysregulated. In order to understand the disturbances in the neuroendocrine-immune systems objectively, we measured and compared various components of the peripheral blood which were considered to reflect the state of these systems, in patients with RA and in control individuals. The serum levels of norepinephrine, interleukin-6 (IL-6), and the CD4/CD8 ratio were higher, whereas the levels of Β-endorphin, adrenocorticotropic hormone, and NK cell activity were lower in the RA subjects than in the control subjects. On the other hand, the serum levels of methionine–enkephalin, epinephrine, corticotropin-releasing factor, cortisol, and CD57 were not significantly different in the two groups. In addition, we demonstrated the effects of hearty laughter, deep emotion with tears, or general anesthesia on the neuroendocrine-immune system. What need the most attention are changes in the IL-6 levels of RA patients. Serum IL-6 levels in RA were significantly higher than in controls, and fell rapidly to as low as half of their initial value after a bout of hearty laughter. Our results suggest that adequate mental intervention might serve to modulate the neuroendocrine-immune system of RA patients which had failed for various reasons.
Soy isoflavonoid equol modulates the growth of benign and malignant prostatic epithelial cells in vitro

The dietary consumption of high levels of soy has been linked to reduced risks for prostate cancer (PC) in Asians and vegetarians. In vitro studies have focused on the two most abundant isoflavones in soy, genistein and daidzein. However, daidzein is differentially metabolized by gut microflora in humans, yielding compounds with very different bioactivities and half‐lives. Asians are significantly more likely to produce the metabolite equol than Caucasians, suggesting its role in the prevention of PC. We hypothesize that equol is a bioactive metabolite that exerts direct antiproliferative effects on prostatic epithelial cells.
Exploring the relation between positive emotions and the functional status of older adults living independently: a systematic review

ABSTRACT Objectives: Literature suggests that positive emotions positively influence physiological parameters but their relation to functioning in the daily life of older adults living independently remains unclear. The present work aims to investigate the relation between positive emotions and functional status in daily life of older people living independently. Method: A systematic literature review was conducted using the PubMed, PsycINFO and Scopus electronic databases. Included works were peer-reviewed empirical studies that analysed the relation between positive emotions and ability to perform activities of daily living with older adults living independently. Results: After removal of duplicates, 10 out of 963 papers met the inclusion criteria. Cross-sectional studies (n = 6) provided limited evidence about a relation between positive emotions and functioning in daily life. However, longitudinal studies (n = 4) provide significant evidence for an interaction between the two factors, suggesting that time influences this interaction. Conclusion: The variety on the design and samples of the studies included in this review does not allow a cohesive conclusion of the results. Nevertheless, limited evidence suggests that higher frequency in the experience of positive emotions might be associated with lower functional limitations. The issue of causality in emotions-functioning remains unclear from the review. Further observational studies are highly recommended, supported by innovative technologies.
Weaving a Computing Fabric

As sources of information relevant to a particular domain proliferate, we need a methodology for locating, aggregating, relating, fusing, reconciling, and presenting information to users. Interoperability thus must occur not only among the information, but also among the different software applications that process it. Given the large number of potential sources and applications, interoperability becomes an extremely large problem for which manual solutions are impractical. A combination of software agents and ontologies can supply the necessary methodology for interoperability.
Predictive control of source and load currents in a direct matrix converter

Matrix converters are capable of managing bidirectional power flows while fully controlling the source and load currents. The topology is characterized by its reduced size and weight because the dc-link stage is not necessary unlike most power converters. A novel control strategy applied to a direct matrix converter is presented in this work. The proposed method allows the control of load and source current in the power converter. The method selects the commutation state of the converter according to an optimization algorithm given by a simple cost functional and the discrete system model. The control goals are regulation of the load current and to force the input current to be sinusoidal with unity displacement power factor. A simulation study is presented to validate the proposed control scheme.
DICTIONARY FOR EFFICIENT SIGNAL COMPRESSION

We consider the problem of learning dictionaries for data compression. Different from ordinary learning methods, the objective is to design a dictionary such that the signal has a low entropy representation in the basis of the dictionary, rather than giving a sparse or low-energy representation. To achieve this goal, we need to consider the effect of quantization on the ratedistortion curve as well as an estimation of the distributions of the coefficients. Based on this probability estimation, the coefficients are computed, quantized and then entropy-coded. As such, we have developed algorithms for different classes of dictionaries; orthonormal, union of orthonormals and general dictionaries with unit-norm atoms, to iteratively learn the dictionary and the distribution models of the coefficients. A mixture of Gaussians is adopted to estimate the probability and is updated using the expectation maximization algorithm together with the dictionary learning. Simulation results on the real seismic data show the effectiveness of the proposed algorithm compared to ordinary dictionary learning methods.
Foldable and Stretchable Liquid Metal Planar Inverted Cone Antenna

A mechanically flexible planar inverted cone antenna (PICA) for ultrawideband (UWB) applications is presented. It can be both folded and stretched significantly without permanent damage or loss of electrical functionality. The antenna is manufactured with a process in which conductors are realized by injecting room temperature liquid metal alloy into micro-structured channels in an elastic dielectric material. The elastic dielectric material together with the liquid metal enables bending with a very small radius, twisting, and stretching along any direction. Port impedance and radiation characteristics of the non-stretched and stretched antenna are studied in simulations and experiments. The presented antenna has a return loss better than 10 dB within 3-11 GHz and a radiation efficiency of > 70% over 3-10 GHz, also when stretched. Tests verify that stretching up to 40% is possible with maintained electrical performance. The presented antenna is useful for example for body-worn antennas and in applications in harsh environments where mechanical flexibility helps improve durability.
Azotobacter vinelandii NADPH:Ferredoxin Reductase Cloning, Sequencing, and Overexpression (*)

Azotobacter vinelandii ferredoxin I (AvFdI) controls the expression of another protein that was originally designated Protein X. Recently we reported that Protein X is a NADPH-specific flavoprotein that binds specifically to FdI (Isas, J. M., and Burgess, B. K.(1994) J. Biol. Chem. 269, 19404-19409). The gene encoding this protein has now been cloned and sequenced. Protein X is 33% identical and has an overall 53% similarity with the fpr gene product from Escherichia coli that encodes NADPH:ferredoxin reductase. On the basis of this similarity and the similarity of the physical properties of the two proteins, we now designate Protein X as A. vinelandii NADPH:ferredoxin reductase and its gene as the fpr gene. The protein has been overexpressed in its native background in A. vinelandii by using the broad host range multicopy plasmid, pKT230. In addition to being regulated by FdI, the fpr gene product is overexpressed when A. vinelandii is grown under N2-fixing conditions even though the fpr gene is not preceded by a nif specific promoter. By analogy to what is known about fpr expression in E. coli, we propose that FdI may exert its regulatory effect on fpr by interacting with the SoxRS regulon.