Miracle-dz/UniFAR-FTUs huggingface dataset:
Two cases of reciprocal translocations in domestic pigs producing small litters.

SUMMARY Two boars of Finnish Yorkshire breed were selected for chromosomal analysis because of their small litters. One had a complex three breakpoint reciprocal translocation where the small distal chromosome segments were fused in new combinations between autosomes 2,9 and 14. This boar with a 2n = 38,XY,t(2;9;14)(q23;q22;q25) karyotype had produced approximately 3.3 piglets per litter and its fertility was reduced by 70% compared to average of litter size in Finnish Yorkshire breed pigs. In another Finnish Yorkshire breed boar, the long arm of autosome 7 had broken and attached to the terminal end of autosome 15. The boar had a 2n = 38,XY, rcp(7q-;15q+)(q24;q26) karyotype. The average of piglets per litter sired by this boar was 5.2 and the litter size was reduced by approximately 50%. The chromosomal rearrangements t(2;9;14) was inherited by four of the boar's offspring studied from two whole litters having seven piglets altogether. Meiotic chromosomes were analysed conventionally from one male translocation carrier offspring of the t(2;9;14) boar. Total sperm count and progressive motility of spermatozoa were within normal limits in one male translocation carrier offspring of the t(2;9;14) boar and in the rcp(7q-;15q+) boar. The two reciprocal translocations seem to have arisen spontaneously in these two boars. ZUSAMMENFASSUNG: Zwei Fälle reziproker Translokationen bei Ebern mit kleinen Nachkommen Würfen Von zwei Finnischen Yorkshire Ebern hatte einer drei komplexe reziproke Translokationen, wo kurze distale Chromosomensegmente zu neuen Kombinatioenen zwischen Autosomen 2, 9 und 14 fusioniert waren. Der Eber mit 2n = 38,XY,t(2;9;14)(q23;q22;q25) Karyotyp hatte Nachkommenwürfe mit etwa 3.3 Ferkel weniger und 70% Fruchtbarkeit der bei dieser Rasse normalen. In einem anderen Eber war der lange Arm von Chromosom 7 gebrochen und am Ende von Chromosom 15: 2n = 38,XY, rcp(7q-; 15q+)(q24;q26) Karyotyp. Nachkommenwurfgröße war 5.2. Das chromosomale Rearrangement t(2;9;14) wurde an 4 Nachkommen in zwei Würfen mit zusammen 7 Ferkel vererbt. Meiotische Chromosomen wurden bei einem männlichen Translokationsträger dieser Nachkommen analysiert. Gesamtspermienenzahl und ihre Vorwärtsbewegung waren in normalen Grenzen bei diesem Nahkommen ebenso wie beim rcp(7q-;15q+) Eber. Die zwei reciproken Translokationen scheinen spontan entstanden zu sein.
Improving prescribing practice in psychiatry: The experience of the Prescribing Observatory for Mental Health (POMH-UK)

Abstract Data from the UK Prescribing Observatory for Mental Health (POMH-UK) suggest that while positive change in prescribing practice can be achieved with focused, audit-based, quality improvement programmes (QIPs) that include feedback of benchmarked performance data and customized change interventions, the time frame for progress is long and improvement generally modest. Improvement may be seen between the baseline audit and re-audit, but supplementary audits conducted in subsequent years can show incremental, sustained improvement in clinical services that have been consistently involved. Audit invariably reveals a marked variation across and within healthcare organizations in the level of compliance with evidence-based clinical practice standards. Additional work has identified various impediments to behavioural change. Some are common to all QIPs, such as the incomplete dissemination of audit results throughout participating organizations and variable uptake of change interventions. Others are specific to particular QIPs, depending on the prescribing issue addressed. For example, in a QIP targeting biochemical monitoring of lithium treatment, the major barrier was the complexity of clinical care arrangements, including multiple interfaces between clinical and laboratory services, which were often not directly or wholly under the control of clinical teams. In this QIP there was little improvement in overall performance against the clinical standards in the total national sample between baseline and re-audit.
Activity classification using the GENEA: optimum sampling frequency and number of axes.

INTRODUCTION The GENEA shows high accuracy for classification of sedentary, household, walking, and running activities when sampling at 80 Hz on three axes. It is not known whether it is possible to decrease this sampling frequency and/or the number of axes without detriment to classification accuracy. The purpose of this study was to compare the classification rate of activities on the basis of data from a single axis, two axes, and three axes, with sampling rates ranging from 5 to 80 Hz. METHODS Sixty participants (age, 49.4 yr (6.5 yr); BMI, 24.6 kg·m (3.4 kg·m)) completed 10-12 semistructured activities in the laboratory and outdoor environment while wearing a GENEA accelerometer on the right wrist. We analyzed data from single axis, dual axes, and three axes at sampling rates of 5, 10, 20, 40, and 80 Hz. Mathematical models based on features extracted from mean, SD, fast Fourier transform, and wavelet decomposition were built, which combined one of the numbers of axes with one of the sampling rates to classify activities into sedentary, household, walking, and running. RESULTS Classification accuracy was high irrespective of the number of axes for data collected at 80 Hz (96.93% ± 0.97%), 40 Hz (97.4% ± 0.73%), 20 Hz (96.86% ± 1.12%), and 10 Hz (97.01% ± 1.01%) but dropped for data collected at 5 Hz (94.98% ± 1.36%). CONCLUSION Sampling frequencies >10 Hz and/or more than one axis of measurement were not associated with greater classification accuracy. Lower sampling rates and measurement of a single axis would result in a lower data load, longer battery life, and higher efficiency of data processing. Further research should investigate whether a lower sampling rate and a single axis affects classification accuracy when considering a wider range of activities.
Cetshwayo kaMpande in Zulu Literature

There is a very large corpus of literature that could be regarded as 'marginal' in South African terms, because it is not accessible to the majority of readers, being written in African languages. This is not a healthy situation for a country that professes multilingualism as one of its greatest assets. In an effort to break the barriers erected by language limitations, this paper presents one of the most popular figures in Zulu literature, namely king Cetshwayo kaMpande, the last independent Zulu monarch. According to Harold Scheub (1985:493), modem Zulu literature has developed along two main directions, reflecting two great concerns: the glories of the historical past and the problems caused by the infiltration of western religion, education and ways of life
Regulation of the MST 1 kinase by autophosphorylation , by the growth inhibitory proteins , RASSF 1 and NORE 1 , and by Ras

MST1 (mammalian Sterile20-like 1) and MST2 are closely related Class II GC (protein Ser/Thr) kinases that initiate apoptosis when transiently overexpressed in mammalian cells. In the present study, we show that recombinant MST1/2 undergo a robust autoactivation in vitro, mediated by an intramolecular autophosphorylation of a single site [MST1(Thr)/MST2(Thr)] on the activation loop of an MST dimer. Endogenous full-length MST1 is activated by a variety of stressful stimuli, accompanied by the secondary appearance of a 36 kDa Thr-phosphorylated, caspasecleaved catalytic fragment. Recombinant MST1 exhibits only 2–5 % activation during transient expression; endogenous MST1 in the cycling HeLa or KB cells has a similar low fractional activation, but 2 h incubation with okadaic acid (1 μM) results in 100 % activation. Endogenous MST1 immunoprecipitated from KB cells is specifically associated with substoichiometric amounts of the growth inhibitory polypeptides RASSF1A and NORE1A (novel Ras effector 1A; a Ras-GTP-binding protein). Coexpression of RASSF1A, RASSF1C, NORE1A and NORE1B with MST1 markedly suppresses MST1(Thr) phosphorylation in vivo and abolishes the ability of MST1 to undergo Mg-ATPmediated autoactivation in vitro; direct addition of purified NORE1A in vitro also inhibits MST1 activation. In contrast, cotransfection of MST1 with NORE1A modified by the addition of a C-terminal CAAX motif results in a substantial increase in MST1(Thr) phosphorylation, as does fusion of a myristoylation motif directly on to the MST1 N-terminus. Moreover, MST1 polypeptides, bound via wild-type NORE1A to Ras(G12V) (where G12V stands for Gly → Val), exhibit higher Thr phosphorylation compared with MST1 bound to NORE1A alone. Nevertheless, serum stimulation of KB cells does not detectably increase the activation state of endogenous MST1 or MST2 despite promoting the recruitment of the endogenous NORE1–MST1 complex to endogenous Ras. We propose that the NORE1/RASSF1 polypeptides, in addition to their role in maintaining the low activity of MST1 in vivo, direct MST1 to sites of activation and perhaps co-localization with endogenous substrates.
Ambulatory Treatment of Multidrug-ResistantStaphylococcus-Infected Orthopedic Implants with High-Dose Oral Co-trimoxazole (Trimethoprim-Sulfamethoxazole)

ABSTRACT We examined the effectiveness and safety of high-dose oral co-trimoxazole (trimethoprim-sulfamethoxazole) for the treatment of orthopedic implants infected with multidrug-resistantStaphylococcus species. The prospective study was conducted between 1989 and 1997 in a university medical center with ambulatory-care services. Patients eligible for the study consisted of those from whom multidrug-resistant Staphylococcus spp. organisms susceptible only to glycopeptides and co-trimoxazole were isolated from their orthopedic implants and for whom there was no contraindication to the treatment. All patients were treated orally with high-dose co-trimoxazole (trimethoprim, 20 mg/kg of body weight/day; sulfamethoxazole, 100 mg/kg/day). Patients with prosthetic hip infections were treated for 6 months, with removal of any unstable prosthesis after 5 months of treatment; patients with prosthetic knee infections were treated for 9 months, with removal of any unstable prosthesis after 6 months of treatment; and patients with infected osteosynthetic devices were treated for 6 months, with removal of the device after 3 months of treatment, if necessary. Monthly clinical evaluations were conducted until the completion of the treatment, and follow-up examinations were conducted regularly for up to 6 years. The overall treatment success rate was 66.7% (26 of 39 patients), with success rates of 62.5% for patients with prosthetic knee infections, 50% for those with prosthetic hip infections, and 78.9% for those with other device infections. Seventeen of the 28 (60.7%) patients who did not have any orthopedic material removed were cured. Eight patients stopped the treatment because of side effects, and one patient was not compliant. In three patients treatment failed because of the appearance of a resistant bacterium. Long-term oral ambulatory treatment with co-trimoxazole appears to be an effective alternative to the conventional medicosurgical treatment of chronic multidrug-resistantStaphylococcus-infected orthopedic implants which includes long-term intravenous antibiotic therapy combined with surgical debridement and removal of foreign material or its subsequent one- or two-stage replacement.
Power-rate control with directional transmission and reception in a cognitive radio network

We study the benefits that antenna directivity and power control can bring to a cognitive radio ad hoc network, in terms of concurrent transmission probability, throughput and energy efficiency. The proposed strategies adequately adjust antenna beam pattern and the transmit power of the secondary users to increase the spectrum reuse while respecting a given constraint on the achievable primary rate. Two power control strategies are described: Rate-Efficient Power Control with Directional Transmission and Reception to maximize the secondary channel rate, and Energy-Efficient Power Control with Directional Transmission and Reception to maximize the energy efficiency of the secondary link. Numerical results show that the proposed schemes increase the concurrent transmission probability and that it is possible to increase the average rate and save energy with a lower cost than that of other proposals.
Performance Evaluation of Intelligent Systems at the National Institute of Standards and Technology (NIST)

The ability to comprehensively evaluate the quantitative and qualitative performance of anintelligent system is critical to accurately predicting how it will perform in various situations.The design of such evaluations is often as much of a research challenge as is the design of theintelligent systems themselves. Over the past decade, the Intelligent Systems Division, a part ofthe National Institute of Standards and Technology, has been at the forefront of assessing theperformance of the various intelligent systems. This article gives a broad overview of some of theevaluation efforts that have been pursued by the Intelligent Systems Division over the past fewyears, including performance evaluation of emergency response robots, sensor systems onunmanned ground vehicles, speech-to-speech translation systems, and the development ofperformance metrics for mixed-palletizing through the use of a simulation environment.Key words: Design of evaluations; emergency response robots; intelligent systems; mixedpalletizing, testing, simulation; robotic vehicle perception systems; search and rescuerobots; speech translation systems.
NCTU-NTUT at IJCNLP-2017 Task 2: Deep Phrase Embedding using bi-LSTMs for Valence-Arousal Ratings Prediction of Chinese Phrases

In this paper, a deep phrase embedding approach using bi-directional long short-term memory (Bi-LSTM) is proposed to predict the valence-arousal ratings of Chinese words and phrases. It adopts a Chinese word segmentation frontend, a local order-aware word, a global phrase embedding representations and a deep regression neural network (DRNN) model. The performance of the proposed method was benchmarked by the IJCNLP 2017 shared task 2. According the official evaluation results, our best system achieved mean rank 6.5 among all 24 submissions.
From spheres to circular cylinders: non-axisymmetric transitions in the flow past rings

Non-axisymmetric simulations verify and extend the results from a previous linear Floquet stability analysis of the wakes of rings. The wakes corresponding to the saturated state of each predicted non-axisymmetric instability mode over the entire aspect ratio range are successfully computed, and isosurface plots are presented elucidating the vortical wake structures. The existence of three non-axisymmetric flow regimes (Modes I, II and III) for the flow past rings with aspect ratios $\textit{Ar\/} \lesssim 3.9$ is verified, as is the existence of non-axisymmetric instabilities of vortex streets in the flow past rings with $\textit{Ar\/} \gtrsim 3.9$. Wakes are computed which correspond to the Mode A and B instabilities found in the flow past a circular cylinder, and a wake is computed which develops from a subharmonic Mode C instability. This wake features an azimuthal wavelength of approximately 1.7 ring cross-section diameters, which is between the azimuthal wavelengths of the Mode A and B instabilities. This mode cannot occur, at least in a pure state, in the flow past a circular cylinder. Nonlinear transition characteristics are predicted by evaluating coefficients of the truncated Landau equation, and transition hysteresis is verified by studying the mode amplitude variation with Reynolds number in the vicinity of the transitions. The regular Mode I and Mode III transitions are found to occur through supercritical and subcritical bifurcations, respectively, and the secondary Hopf bifurcations to these transitions, as well as the Mode II Hopf transition, are found to be supercritical. We verify that the Mode A and Mode B transitions are subcritical and supercritical, respectively, and we determine that the nature of the Mode C transition is dependent on aspect ratio. Landau constants are evaluated for the Hopf transitions throughout the aspect ratio range studied.
Evaluation of Outcomes of a Pharmacist-Run, Outpatient Insulin Titration Telepharmacy Service

Abstract Purpose Diabetes can pose a significant disease burden for patients and is often challenging to manage in underserved patient populations with limited access to care. A pilot study was conducted to determine the impact of a pharmacist-run insulin titration service, provided via telephone, to patients of a local ambulatory care clinic with a large medically, underserved patient population. The pilot service was implemented in Spring 2018 at Cooper Green Mercy Health Services (CGMHS) and was provided by an affiliate clinical pharmacist who is also on faculty at Samford University's McWhorter School of Pharmacy. Patients who received care within the CGMHS diabetes clinic were eligible for referral to the service. The service was provided via a collaborative practice agreement. The purpose of this study was to evaluate and compare clinical outcomes of patients who received the telepharmacy service versus the standard of care. Standard of care was defined as patients whose insulin therapy was managed solely by the primary care provider or by a diabetes clinic provider, without clinical pharmacist involvement in the patient's care. Methods This manuscript presents the results of a retrospective chart review conducted at CGMHS of patients, ages 19 or older, with a documented diagnosis of type 1 or type 2 diabetes who received care during the timeframe of February 2018 through September 2018 – the initial months of the pilot telepharmacy service. Results Sixty-seven patients met criteria for inclusion in the analysis - 16 managed in the telepharmacy service, 28 in diabetes clinic, and 23 in primary care. Patients in the telepharmacy group achieved a mean A1c change of -1.14% compared with -0.88% in the diabetes clinic group and +0.21% in the primary care group (p=0.061). In the telepharmacy group, 43.75% of patients experienced at least a 1% reduction in A1c from baseline compared with 35.71% in the diabetes clinic group and 26.09% in primary care (p=0.51). Conclusion Integration of the clinical pharmacy services for insulin titration positively affected patients' degree of glucose control. Although no statistically significant reductions in A1c were observed in this study, it should be noted that pharmacist intervention was associated with a modestly higher percent A1c reduction from baseline vs. the standard of care. The pharmacist-run service produced changes in clinical outcomes that numerically exceeded those experienced by patients receiving specialty care, in the diabetes clinic, and within primary care. As a result of this study, the pilot program has remained in effect and is in the initial stages of expansion of the consult service to eligible primary care patients.
Discovering and Exploiting Additive Structure for Bayesian Optimization

Bayesian optimization has proven invaluable for black-box optimization of expensive functions. Its main limitation is its exponential complexity with respect to the dimensionality of the search space using typical kernels. Luckily, many objective functions can be decomposed into additive sub-problems, which can be optimized independently. We investigate how to automatically discover such (typically unknown) additive structure while simultaneously exploiting it through Bayesian optimization. We propose an efﬁcient algorithm based on Metropolis–Hastings sampling and demonstrate its efﬁcacy empirically on synthetic and real-world data sets. Throughout all our experiments we reliably discover hidden additive structure whenever it exists and exploit it to yield signiﬁcantly faster convergence.
Effective coverage gap repairing in wireless sensor network

In the heterogeneous sensor network, energy depleted sensors result in coverage gap. The replacement of this energy depleted sensor is a difficult task and has a larger impact on network coverage. To maximise coverage, this paper presents a proactive approach called Coverage Gap Repairing (CGR) algorithm. CGR is an extension of the VorLag algorithm in which CGR considers the mobility of sensors of null polygon and non-null polygon. The sensors of the null polygon move towards the energy depleting sensors to repair the coverage gap before it gets energy depleted completely, thus improves coverage. In the unavailability of sensors of null polygon, CGR employs an alternate technique that exploits Alternate Repairing Sensor Selection (ARSS) process for choosing more suitable repairing sensor with low cost. The NS2-based simulation results prove that the proposed work yields extensive coverage with high coverage profit and less traverse distance.
Trematodes from Red Sea fishes: Pachycreadium lethrini sp. nov. (Opecoelidae Ozaki, 1925) and Pseudometadena aegyptensis sp. nov. (Cryptogonimidae Ward, 1917), with a review of their genera

Specimens of the fishes Lethrinus nebulosus Forsskål (Lethrinidae) and Diplodus noct Valenciennes (Sparidae) were caught in the Red Sea off the coast of Sharm El-Sheikh, South Sinai, Egypt. Ten (33%) and 12 (24%) of these fishes, respectively, were found to harbour intestinal trematodes. L. nebulosus was parasitised by Pachycreadium lethrini sp. nov. (Opecoelidae) and D. noct by Pseudometadena aegyptensis sp. nov. (Cryptogonimidae). P. lethrini sp. nov. is unique in having distinctly unequal testes, contiguous gonads arranged obliquely in the right side of hindbody and a small egg size. However, it differs from each of the other three species of the genus in several other features: from P. gastrocotylum (Manter, 1940) Manter, 1954 in having a smaller sucker ratio and vitelline follicles terminating anteriorly at the level of intestinal bifurcation; from P. carnosum (Rudolphi, 1819) Cortini et Ferretti, 1959 in having a smaller body, a smaller sucker ratio, a genital pore situated ventrally to the anterior border of pharynx, a pretesticular ovary and vitelline follicles extending anteriorly to the level of intestinal bifurcation; and from P. lerneri Sogandares-Bernal, 1959 in having a larger body, a smaller sucker ratio and an unlobed ovary. P. angolensis Aleshkina et Gaevskaya, 1985 is considered an invalid species in Pachycreadium. P. aegyptensis sp. nov. is similar to P. celebesensis Yamaguti, 1952, but mainly differs in having a larger pharynx, a much shorter oesophagus, extensive vitelline acini and a shorter seminal vesicle. Pachycreadium Manter, 1954 and Pseudometadena Yamaguti, 1952 are briefly reviewed.
Technical management notes: Delphic Goal Programming (DGP): A multi-objective cost/benefit approach to R&D portfolio analysis

A systematic way for allocating resources among different research and development (R&D) projects in a multiple objective environment is developed. For this purpose, the Delphic Goal Programming (DGP) is proposed as follows: initially, a Delphi inquiry is conducted to identify the objectives to be considered in problem formulation. Successive rounds of Delphi are then utilized to prioritize these objectives, and to determine the relative weight and the aspiration level for each objective. Finally, through Delphi inquiry, a portfolio of R&D projects to achieve these objectives is identified. The results of the Delphi inquiry are used to build a goal programming model. This model than provides an allocation pattern for projects to achieve organizational objectives. The application of the model is discussed and illustrated.