Miracle-dz/UniFAR-FTUs huggingface dataset:
Scheme Trope Chroma Chengyir. Figuration in Chinese Four-character Idioms

In this paper, we have three inter-related goals: to explore the cognitive interrelations among form, content, and intention among Chinese fourcharacter idioms, or chengyir, to update the standard taxonomy of figures; and to criticize the self-imposed limitation of cognitive figuration studies to only one wing of that taxonomy. The standard taxonomy has two categories: schemes (deviation from form, like rhyme), and tropes (deviation from content, like metaphor). Cognitive studies of figuration are preoccupied with tropes alone, and with only a few of those, while the traditional taxonomy badly mishandles figures like interrogatio (rhetorical question), which are deviations of intention (that we call chroma). Our preliminary survey of chengyu reveals the interplay of these three categories; highlights the importance of schemes, largely neglected in cognitive studies of figuration; and crucially implicates chroma, largely neglected in all theories of figuration.
“It’s All up to You”: How Welfare-to-Work Educational Programs Construct Workforce Success

This article discusses how two welfare education programs construct workforce success. Discourse about success in these programs falls into two basic camps: an individual-based selfmotivation perspective and an external, structural, socioeconomic perspective. Although the individualistic perspective adhered to by the programs came into conflict with structural problems faced by students, the programs ultimately chose to uphold a perspective that reinforces the American myth of success that has been prevalent in the United States since the 17th century.
Improving throughput and maintaining fairness using parallel TCP

Applications that require good network performance often use parallel TCP streams and TCP modifications to improve the effectiveness of TCP. If the network bottleneck is fully utilized, this approach boosts throughput by unfairly stealing bandwidth from competing TCP streams. Improving the effectiveness of TCP is easy, but improving effectiveness while maintaining fairness is difficult. In this paper, we describe an approach we implemented that uses a long virtual round trip time in combination with parallel TCP streams to improve effectiveness on underutilized networks. Our approach prioritizes fairness at the expense of effectiveness when the network is fully utilized. We compared our approach with standard parallel TCP over a wide-area network, and found that our approach preserves effectiveness and is fairer to competing traffic than standard parallel TCP.
Joint optimization of QoE and fairness through network assisted adaptive mobile video streaming

MPEG has recently proposed Server and Network Assisted Dynamic Adaptive Streaming over HTTP (SAND-DASH) for video streaming over the Internet. In contrast to the purely client-based video streaming in which each client makes its own decision to adjust its bitrate, SAND-DASH enables a group of simultaneous clients to select their bitrates in a coordinated fashion in order to improve resource utilization and quality of experience. In this paper, we study the performance of such an adaptation strategy compared to the traditional approach with large number of clients having mobile Internet access. We propose a multi-servers multi-coordinators (MSs-MCs) framework to model groups of remote clients accessing video content replicated to spatially distributed edge servers. We then formulate an optimization problem to maximize jointly the QoE of individual clients, proportional fairness in allocating the limited resources of base stations as well as balancing the utilized resources among multiple serves. We then present an efficient heuristic-based solution to the problem and perform simulations in order to explore parameter space of the scheme as well as to compare the performance to purely client-based DASH.
High Efficiency Concurrent Embedded Block Coding Architecture for JPEG 2000

Embedded block coding with optimized truncation (EBCOT) is the most important part of JPEG 2000. Due to the bit level operation and the three-pass scanning technique, the EBCOT may take more than 50% operation time in the JPEG 2000. This paper presents a high efficiency concurrent EBCOT (HECEBC) entropy encoder hardware architecture. The proposed HECEBC can concurrently process the four samples in a stripe column. Furthermore this architecture can be extended to process several stripe columns concurrently for the JPEG 2000 to accomplish high resolution applications in real time. Besides, the HECEBC uses the technique of concentrated context window to stabilize the Context-Decision (CX-D) output to relax the load in between the arithmetic encoder (AE) and the parallel-in-serial-out (PISO) buffer to triple the EBC performance.
Risk Perceptions of Dating Violence Among College Women: The Role of Experience and Depressive Symptoms

A great deal of research on risk perceptions has examined predictors of personal and comparative risk judgments, but little work has examined predictors such as personal experience and depression with respect to dating violence (DV) risk perceptions. Results from a survey of college women (N = 192) indicated that women showed optimistic comparative risk judgments in that they thought their personal risk was lower than other women's risk of experiencing future DV. Depressive symptoms and greater experience with DV, sexual abuse, and violence socialization were associated with elevated personal risk ratings. The relationship between previous DV experience and personal risk ratings was partially mediated by depressive symptoms. Results are discussed as they relate to the existing literature on risk perceptions.
Mannose 6-Phosphate/Insulin-like Growth Factor–II Receptor Targets the Urokinase Receptor to Lysosomes via a Novel Binding Interaction

The urokinase-type plasminogen activator receptor (uPAR) plays an important role on the cell surface in mediating extracellular degradative processes and formation of active TGF-β, and in nonproteolytic events such as cell adhesion, migration, and transmembrane signaling. We have searched for mechanisms that determine the cellular location of uPAR and may participate in its disposal. When using purified receptor preparations, we find that uPAR binds to the cation-independent, mannose 6-phosphate/insulin-like growth factor–II (IGF-II) receptor (CIMPR) with an affinity in the low micromolar range, but not to the 46-kD, cation-dependent, mannose 6-phosphate receptor (CDMPR). The binding is not perturbed by uPA and appears to involve domains DII + DIII of the uPAR protein moiety, but not the glycosylphosphatidylinositol anchor. The binding occurs at site(s) on the CIMPR different from those engaged in binding of mannose 6-phosphate epitopes or IGF-II. To evaluate the significance of the binding, immunofluorescence and immunoelectron microscopy studies were performed in transfected cells, and the results show that wild-type CIMPR, but not CIMPR lacking an intact sorting signal, modulates the subcellular distribution of uPAR and is capable of directing it to lysosomes. We conclude that a site within CIMPR, distinct from its previously known ligand binding sites, binds uPAR and modulates its subcellular distribution.
Anaplastic Large Cell Lymphoma--A Rare Disorder in Southern Taiwan

Anaplastic large cell lymphoma (ALCL) is a subgroup of non-Hodgkin's lymphomas with large lymphoma cells expressing CD30 antigen. This entity has rarely been reported in Taiwan. We performed a retrospective clinicopathologic study in a medical center in southern Taiwan during a 13-year period and identified 13 cases. There were 10 males and 3 females with a median age of 49 years old. Seven presented with pure nodal disease and 5 had bony involvement. The staging results were stage I (5 patients), II (1), III (1), and IV (4). The pathologic subtypes were common variant (10), lymphohistiocytic variant (2), and small cell variant (1). Eleven tumors were of T-cell lineage; 2, null-cell. Immunohistochemically, 5 tumors (38.5%) expressed cytotoxic markers, T-cell intracellular antigen-1 and/or granzyme B. Two tumors (15.4%) expressed anaplastic lymphoma kinase (ALK). Long-term follow-up information was available in 8 patients. The 2 patients with ALK-expressing tumors (37 and 49 years old) were free of disease for 61 and 54 months, respectively. The other 6 patients were either died of disease (5 patients) or experienced relapse with progressive disease (1). In conclusion, we reported the largest series of ALCL in Taiwan. We confirmed ALK-expressing ALCL carries favorable prognosis and ALK-negative ALCL has similar poor prognosis as non-anaplastic T-cell lymphoma. As compared to the previous reports from the West, our ALK positive rate was lower and the age of our ALK-positive patients was older. A larger national or multi-institutional study is needed for further characterization of ALCL in Taiwan.
Social class differences and the identification of sex in children's speech

ABSTRACT Judges were asked to identify the sex of prepubertal children by listening to their tape-recorded voices. More incorrect guesses were made of working class girls than of their male counterparts. For middle-class children, however, the pattern was reversed, with more boys being misidentified as girls than the opposite. These findings are related to work demonstrating an association between masculinity and working-class speech, and to the ‘covert prestige’ attaching to such speech as a result. Some practical implications of the results for researchers in the field of child language are also discussed.
The combination of sorafenib and radiation preferentially inhibits breast cancer stem cells by suppressing HIF-1α expression

The importance of anticancer stem cell research for breast cancer lies in the possibility of providing new approaches for an improved understanding of anticancer activity and cancer treatment. In this study, we demonstrated that the preclinical therapeutic efficacy of combining the multikinase inhibitor sorafenib with radiation was more effective in hypoxia-exposed breast cancer stem cells. We assessed cell viability and Annexin V to evaluate the combined effect of sorafenib and radiation following exposure to hypoxia. Our results showed that the synergistic cytotoxicity increased tumor cell apoptosis significantly and reduced cell proliferation in MDA-MB-231 and MCF-7 cells under hypoxic conditions compared to sorafenib or radiation alone in vitro. Additionally, the combined treatment induced G2/M cell cycle arrest. Notably, the combination of sorafenib and radiation eliminated CD44+CD24−/low cells preferentially, which highly expressed hypoxia-inducible factor (HIF)-1α and effectively inhibited primary and secondary mammosphere formation in MDA-MB-231 cells. A combined effect on MDA-MB-231 cells in response to hypoxia was shown by inhibiting angiogenesis and metastasis by suppression of HIF-1α and matrix metalloproteinase-2 (MMP-2). Collectively, these results indicate that the efficacy of sorafenib combined with radiation for treating human breast cancer cells is synergistic and suggest a new therapeutic approach to prevent breast cancer progression by eliminating breast cancer stem cells.
WORK‐FAMILY POLICIES AND PROGRAMMES IN A PROFESSIONAL SERVICES FIRM: USES AND EFFECTIVENESS

Schwartz (1992) has suggested that professional firms may be the vanguard in supporting the career advancement of women. Professional firms typically recruit and hire a considerable number of university graduates that are women. In the last few years, almost half the new hires by public accounting firms have been women. In addition, women graduates have performed as well as their male counterparts in their university programmes. It also takes less time to advance to senior management (admission to partnership) in professional firms than is the case in most large private sector corporations. Finally, the evaluation of performance in professional service firms is based on productivity (e.g., billable hours, new business development) which are more objective than performance ratings of one's manager. In addition, many professional firms have institutionalised new technologies which make it easier to work flexibly and at home (computers, fax machines).
Engaging patients in decision-making and behavior change to promote prevention

Effectively engaging patients in their care is essential to improve health outcomes, improve satisfaction with the care experience, reduce costs, and even benefit the clinician experience. This chapter will address the topic of patient engagement directly and review the relationships between health literacy and patient engagement. While there are many ways to define patient and family engagement, this chapter will consider engagement as "patients, families, their representatives, and health professionals working in active partnership at various levels across the health care system - direct care, organizational design and governance, and policy making - to improve health and health care [1]. " We will specifically focus on the patient engagement and health literacy needs for three scenarios (1) decision-making, (2) health behavior change, and (3) chronic disease management; we will include the theoretical underpinnings of engagement, the systems required to better support patient engagement, how social determinants of health influence patient engagement, and practical examples to demonstrate approaches to better engage patients in their health and wellbeing. We will close by describing the future of patient engagement, which extends beyond the traditional domains of decision-making and self-care to describe how patient engagement can influence the design of the healthcare delivery system; local, state, and national health policies; and future research relevant to the needs and experiences of patients.
Transcriptional and Proteomic Analysis of the Aspergillus fumigatus ΔprtT Protease-Deficient Mutant

Aspergillus fumigatus is the most common opportunistic mold pathogen of humans, infecting immunocompromised patients. The fungus invades the lungs and other organs, causing severe damage. Penetration of the pulmonary epithelium is a key step in the infectious process. A. fumigatus produces extracellular proteases to degrade the host structural barriers. The A. fumigatus transcription factor PrtT controls the expression of multiple secreted proteases. PrtT shows similarity to the fungal Gal4-type Zn(2)-Cys(6) DNA-binding domain of several transcription factors. In this work, we further investigate the function of this transcription factor by performing a transcriptional and a proteomic analysis of the ΔprtT mutant. Unexpectedly, microarray analysis revealed that in addition to the expected decrease in protease expression, expression of genes involved in iron uptake and ergosterol synthesis was dramatically decreased in the ΔprtT mutant. A second finding of interest is that deletion of prtT resulted in the upregulation of four secondary metabolite clusters, including genes for the biosynthesis of toxic pseurotin A. Proteomic analysis identified reduced levels of three secreted proteases (ALP1 protease, TppA, AFUA_2G01250) and increased levels of three secreted polysaccharide-degrading enzymes in the ΔprtT mutant possibly in response to its inability to derive sufficient nourishment from protein breakdown. This report highlights the complexity of gene regulation by PrtT, and suggests a potential novel link between the regulation of protease secretion and the control of iron uptake, ergosterol biosynthesis and secondary metabolite production in A. fumigatus.
Edinburgh Research Explorer P2: A Baseline Approach to Planning with Control Structures and Programs

Many planners model planning domains with “primitive actions,” where action preconditions are represented by sets of simple tests about the state of domain ﬂuents, and action effects are described as updates to these ﬂuents. Queries and updates are typically combined in only very limited ways, for instance using logical operators and quantiﬁcation. By comparison, formalisms like Golog permit “complex actions,” with control structures like if - else blocks and while loops, and view actions as programs. In this paper we explore the idea of planning directly with complex actions and programs. We describe the structure of a simple planner based on undirected search, that generates plans by simulating the execution of action programs before they are added to a plan. An initial evaluation compares this approach against a classical heuristic planner using a domain whose program structures have been compiled into ordinary PDDL actions. Initial re-sults illustrate that in certain domains, planning directly with programs can lead to a signiﬁcant performance improvement. This work offers a baseline planner to compare against alternate approaches to planning with programs.
La communication du développement touristique durable des sites du patrimoine mondial

Parmi les objectifs de la Convention du patrimoine mondial, on retrouve la volonte de developper de facon durable les sites inscrits, ainsi que de communiquer et de sensibiliser le public a l’exceptionnalite de ces lieux. L’industrie touristique, de par son role dans le developpement des lieux et dans la communication aupres des publics, s’avere un partenaire central dans la diffusion de ce message. Cette etude presente comment la communication des offices de tourisme peut aider a rencontrer les objectifs de sensibilisation au developpement durable et exemplifiant de bonnes pratiques de communication.
The zCOSMOS Survey. The dependence of clustering on luminosity and stellar mass at z=0.2-1

We study the dependence of galaxy clustering on luminosity and stellar mass at redshifts z ~ [0.2-1] using the first zCOSMOS 10K sample. We measure the redshift-space correlation functions xi(rp,pi) and its projection wp(rp) for sub-samples covering different luminosity, mass and redshift ranges. We quantify in detail the observational selection biases and we check our covariance and error estimate techniques using ensembles of semi-analytic mock catalogues. We finally compare our measurements to the cosmological model predictions from the mock surveys. At odds with other measurements, we find a weak dependence of galaxy clustering on luminosity in all redshift bins explored. A mild dependence on stellar mass is instead observed. At z~0.7, wp(rp) shows strong excess power on large scales. We interpret this as produced by large-scale structure dominating the survey volume and extending preferentially in direction perpendicular to the line-of-sight. We do not see any significant evolution with redshift of the amplitude of clustering for bright and/or massive galaxies. The clustering measured in the zCOSMOS data at 0.5=10 is only marginally consistent with predictions from the mock surveys. On scales larger than ~2 h^-1 Mpc, the observed clustering amplitude is compatible only with ~1% of the mocks. Thus, if the power spectrum of matter is LCDM with standard normalization and the bias has no unnatural scale-dependence, this result indicates that COSMOS has picked up a particularly rare, ~2-3 sigma positive fluctuation in a volume of ~10^6 h^-1 Mpc^3. These findings underline the need for larger surveys of the z~1 Universe to appropriately characterize the level of structure at this epoch.
Social Cognition in Schizophrenic Patients: The Effect of Semantic Content and Emotional Prosody in the Comprehension of Emotional Discourse

Background: The recognition of the emotion expressed during conversation relies on the integration of both semantic processing and decoding of emotional prosody. The integration of both types of elements is necessary for social interaction. No study has investigated how these processes are impaired in patients with schizophrenia during the comprehension of an emotional speech. Since patients with schizophrenia have difficulty in daily interactions, it would be of great interest to investigate how these processes are impaired. We tested the hypothesis that patients present lesser performances regarding both semantic and emotional prosodic processes during emotional speech comprehension compared with healthy participants. Methods: The paradigm is based on sentences built with emotional (anger, happiness, or sadness) semantic content uttered with or without congruent emotional prosody. The study participants had to decide with which of the emotional categories each sentence corresponded. Results: Patients performed significantly worse than their matched controls, even in the presence of emotional prosody, showing that their ability to understand emotional semantic content was impaired. Although prosody improved performances in both groups, it benefited the patients more than the controls. Conclusion: Patients exhibited both impaired semantic and emotional prosodic comprehensions. However, they took greater advantage of emotional prosody adjunction than healthy participants. Consequently, focusing on emotional prosody during carrying may improve social communication.
Adding to Yersinia enterocolitica Gene Pool Diversity: Two Cryptic Plasmids from a Biotype 1A Isolate

We report the nucleotide sequence of two novel cryptic plasmids (4357 and 14 662 base pairs) carried by a Yersinia enterocolitica biotype 1A strain isolated from pork. As distinguished from most biotype 1A strains, this isolate, designated 07-04449, exhibited adherence to eukaryotic cells. The smaller plasmid pYe4449-1 carries five attributable open reading frames (ORFs) encoding the first CcdA/CcdB-like antitoxin/toxin system described for a Yersinia plasmid, a RepA-like replication initiation protein, and mobilizing factors MobA and MobC. The deduced amino acid sequences showed highest similarity to proteins described in Salmonella (CcdA/B), Klebsiella (RepA), and Plesiomonas (MobA/C) indicating genomic fluidity among members of the Enterobacteriaceae. One additional ORF with unknown function, termed ORF5, was identified with an ancestry distinct from the rest of the plasmid. While the C+G content of ORF5 is 38.3%, the rest of pYe4449-1 shows a C+G content of 55.7%. The C+G content of the larger plasmid pYe4449-2 (54.9%) was similar to that of pYe4449-1 (53.7%) and differed from that of the Y. enterocolitica genome (47.3%). Of the 14 ORFs identified on pYe4449-2, only six ORFs showed significant similarity to database entries. For three of these ORFs likely functions could be ascribed: a TnpR-like resolvase and a phage replication protein, localized each on a low C+G island, and DNA primase TraC. Two ORFs of pYe4449-2, ORF3 and ORF7, seem to encode secretable proteins. Epitope-tagging of ORF3 revealed protein expression at 4°C but not at or above 27°C suggesting adaptation to a habitat outside swine. The hypothetical protein encoded by ORF7 is the member of a novel repeat protein family sharing the DxxGN(x)nDxxGN motif. Our findings illustrate the exceptional gene pool diversity within the species Y. enterocolitica driven by horizontal gene transfer events.