Miracle-dz/UniFAR-FTUs huggingface dataset:
Third trimester anemia extends the length of hospital stay after delivery

Objective: To assess the relationship between maternal third trimester anemia and hospital stay after delivery. Materials and Methods: In this retrospective cross-sectional study, 695 women aged 18-42 years were included between January 2016 and June 2016. Obstetric outcomes and fetal outcomes were measured. Statistical analysis was performed using SPSS, version 19.0 (SPSS, Chicago, Illinois). Results: The prevalence of anemia in this study was 15.2%. The study population was divided into three groups according to hemoglobin (Hb) levels. Group 1 consisted of patients with Hb <8.5 g/dL, group 2 Hb 8.5-11 g/dL, and group 3 Hb >11 g/dL. Higher levels of Hb were associated with shorter stay in hospital (p=0.028). In binary comparison, no significant difference was observed between groups 2 and 3, whereas it was statistically different from group 1. Fetal weight (p=0.562), neonatal intensive care unit admission (p=0.596), APGAR score 1st (p=0.674) and 5th minute (p=0.876), type of delivery (p=0.831), and gestational age (p=0.798) were not statistically different between the groups; however, hospitalization time was significantly different (p=0.028). Conclusion: Maternal anemia in the third trimester prolongs hospitalization time after delivery. Anemia effects pregnancy and the fetus in the postpartum period in addition to the prenatal period.
The fall (and rise) of labour share in New Zealand

ABSTRACT The share of national income going to labour in New Zealand fell substantially between the 1970s and the end of the century. Approximately half of this decline was then recovered in the following decade. In this paper, we argue that the decline from the mid-1980s onwards is due to public sector reforms. Corporatisation re-orientated the public trading enterprises away from a broad range of social and trading objectives towards generating profits, while increased fiscal discipline in non-market government departments reduced payroll costs. Consistent with this hypothesis, we show that most of the decline in aggregate labour share from the mid-1980s onwards can be attributed to a significant fall in the labour share of the public sector. To more formally analyse the effects of the reforms, we build a simple model of structural transition. The model yields several predictions that are consistent with observed trends in sectoral labour share. First, there is a large and permanent decline in public sector labour share after the reforms. Second, there is a smaller, short-run decline in private sector labour share that is reversed over the long run. The model can, therefore, explain not only the decline in aggregate labour share from the mid-1980s onwards; it can also explain the partial recovery in labour share beginning in 2002.
A 2.5mW 2Mb/s fully integrated impulse-FM-UWB transceiver in 0.18µm CMOS

This paper presents a fully integrated self-quenched super-regenerative impulse-FM-UWB transceiver architecture for wireless body area networks. The design architecture consists of two different LC self-quenched oscillators tuned at 3.5GHz and 4.5GHz. In transmitting mode, both oscillators are turned on and off to generate impulse-FM-UWB data pattern. In receiving mode, these oscillators act as self-quenched super-regenerative filters to detect impulse-FM-UWB data pattern. The test structure of the transceiver has been implemented in 0. 18µm CMOS technology. The self quenched filter consumes 1mW and 1.5mW from a 1.5V supply in transmit and receive modes, respectively. A UWB signal to in-band interferer ratio of −36 dB is achieved for a data rate of 2Mbit/s and a sensitivity of −95dBm.
Sense Contextualization in a Dependency-Based Compositional Distributional Model

Little attention has been paid to distributional compositional methods which employ syntactically structured vector models. As word vectors belonging to different syntactic categories have incompatible syntactic distributions, no trivial compositional operation can be applied to combine them into a new compositional vector. In this article, we generalize the method described by Erk and Padó (2009) by proposing a dependency-base framework that contextualize not only lemmas but also selectional preferences. The main contribution of the article is to expand their model to a fully compositional framework in which syntactic dependencies are put at the core of semantic composition. We claim that semantic composition is mainly driven by syntactic dependencies. Each syntactic dependency generates two new compositional vectors representing the contextualized sense of the two related lemmas. The sequential application of the compositional operations associated to the dependencies results in as many contextualized vectors as lemmas the composite expression contains. At the end of the semantic process, we do not obtain a single compositional vector representing the semantic denotation of the whole composite expression, but one contextualized vector for each lemma of the whole expression. Our method avoids the troublesome high-order tensor representations by defining lemmas and selectional restrictions as first-order tensors (i.e. standard vectors). A corpus-based experiment is performed to both evaluate the quality of the compositional vectors built with our strategy, and to compare them to other approaches on distributional compositional semantics. The experiments show that our dependency-based compositional method performs as (or even better than) the state-of-the-art.
Replication-dependent and -independent Responses of RAD18 to DNA Damage in Human Cells*

Postreplication repair facilitates tolerance of DNA damage during replication, overcoming termination of replication at sites of DNA damage. A major post-replication repair pathway in mammalian cells is translesion synthesis, which is carried out by specialized polymerase(s), such as polymerase η, and is identified by focus formation by the polymerase after irradiation with UVC light. The formation of these foci depends on RAD18, which ubiquitinates PCNA for the exchange of polymerases. To understand the initial processes in translesion synthesis, we have here analyzed the response to damage of RAD18 in human cells. We find that human RAD18 accumulates very rapidly and remains for a long period of time at sites of different types of DNA damage, including UVC light-induced lesions, and x-ray microbeam- and laser-induced single-strand breaks, in a cell cycle-independent manner. The accumulation of RAD18 at DNA damage is observed even when DNA replication is inhibited, and a small region containing a zinc finger motif located in the middle of RAD18 is essential and sufficient for the replication-independent damage accumulation. The zinc finger motif of RAD18 is not necessary for UV-induced polymerase η focus formation, but another SAP (SAF-A/B, Acinus and PIAS) motif near the zinc finger is required. These data indicate that RAD18 responds to DNA damage in two distinct ways, one replication-dependent and one replication-independent, involving the SAP and zinc finger motifs, respectively.
Emergence of Dual Resistance to Zidovudine and Lamivudine in HIV‐1‐Infected Patients Treated With Zidovudine Plus Lamivudine as Initial Therapy

Summary: Presence of mutations associated with resistance to zidovudine or lamivudine was determined in isolates of HIV‐1 obtained after long‐term follow‐up of 64 infected individuals who received zidovudine, lamivudine, or both drugs as initial antiretroviral therapy. Zidovudine resistance mutations were less frequent in isolates from patients treated with combination lamivudine plus zidovudine compared with zidovudine alone, but these mutations accumulated over time. Phenotypic resistance to both drugs was found in isolates from 3 of 23 patients. In 3 other patients, lamivudineresistant virus detected at week 12 was replaced by wild‐type virus after longer follow‐up, which correlated with a return to baseline levels of plasma HIV‐1 RNA. These results show that dual resistance to zidovudine and lamivudine develops over time despite the delayed emergence of zidovudine‐resistant mutations. These results also suggest a selective advantage in vivo for HIV‐1 species that are wild‐type at RT codon 184.
The B-shape and B-complex for three-dimensional spheres

In recent years, there have been extensive studies on biological systems such as proteins. Being one of the most important aspects, the geometry has been more important since the morphology of a molecular system is known to determine the critical functions of the molecule. In the study of the shape and the structure of a molecule, the representation of proximity information among atoms in the molecule is the most fundamental research issue. In this paper, we present a The beta-shape and beta-complex for three-dimensional spheres-shape and a The beta-shape and beta-complex for three-dimensional spheres-complex for a set of atoms with arbitrary sizes for a faster response to the topological queries among atoms. These concepts are the generalizations of the well-known a-shape and a- complex (and their weighted counterparts as well). To compute a The beta-shape and beta-complex for three-dimensional spheres-shape, we first compute the Voronoi diagram of atoms and then transform the Voronoi diagram to a quasi- triangulation which is the topological dual of the Voronoi diagram. Then, we compute a The beta-shape and beta-complex for three-dimensional spheres-complex from the quasi- triangulation by analyzing the valid intervals for each simplex in the quasi-triangulation. It is shown that a The beta-shape and beta-complex for three-dimensional spheres-complex can be computed in O(m) time in the worst case from the Voronoi diagram of atoms, where m is the number of simplices in the quasi-triangulation. Then, a The beta-shape and beta-complex for three-dimensional spheres-shape for a particular The beta-shape and beta-complex for three-dimensional spheres consisting of k simplices can be located O(log m + k) time in the worst case from the simplicies in the The beta-shape and beta-complex for three-dimensional spheres-complex sorted according to the interval values.
How are Open Source Practices Possible within a Medical Diagnostics Company?: Developing and Testing a Maturity Model of Inner Source Implementation

Open Source Software (OSS) development has seen a considerable increase in attention over the last few years. The success of various OSS projects, such as Linux and Apache, is now widely recognized. Many organizations have shown interest not only in using OSS, but also in applying the underlying collaborative practices within their internal software development activities; this phenomenon is known as Inner Source. By combining best practices of OSS development from the current Inner Source literature, we develop a new model that allows us to rate an organization's maturity level regarding the adoption of Inner Source. By testing our model within a medical diagnostics corporation, we present various insights on Inner Source efforts and how Inner Source can improve software development.
SMARTS: reconstructing disease response networks from multiple individuals using time series gene expression data

MOTIVATION Current methods for reconstructing dynamic regulatory networks are focused on modeling a single response network using model organisms or cell lines. Unlike these models or cell lines, humans differ in their background expression profiles due to age, genetics and life factors. In addition, there are often differences in start and end times for time series human data and in the rate of progress based on the specific individual. Thus, new methods are required to integrate time series data from multiple individuals when modeling and constructing disease response networks. RESULTS We developed Scalable Models for the Analysis of Regulation from Time Series (SMARTS), a method integrating static and time series data from multiple individuals to reconstruct condition-specific response networks in an unsupervised way. Using probabilistic graphical models, SMARTS iterates between reconstructing different regulatory networks and assigning individuals to these networks, taking into account varying individual start times and response rates. These models can be used to group different sets of patients and to identify transcription factors that differentiate the observed responses between these groups. We applied SMARTS to analyze human response to influenza and mouse brain development. In both cases, it was able to greatly improve baseline groupings while identifying key relevant TFs that differ between the groups. Several of these groupings and TFs are known to regulate the relevant processes while others represent novel hypotheses regarding immune response and development. AVAILABILITY AND IMPLEMENTATION Software and Supplementary information are available at http://sb.cs.cmu.edu/smarts/. CONTACT zivbj@cs.cmu.edu SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
A GIS-based urban landscape study of Lanzhou city, China

The study area includes four districts (Chengguan, Qilihe, Anning, and Xigu) of Lanzhou city, whose total area and population is 227.98 km2 and 1,800,000 respectively. In this study, we aim to resolve two questions: (1) from the spatial analysis, we want to know what changes have happened on urban landscape characteristics from 1976 to 2004? (2) What is the main driving force behind the changes? This research is based on American quick bird remote sensing image of 2004 and the topographical map of Lanzhou city, the detailed land use data and some cadastral data in 1976 are collected as well as the current land use data. Based on the calculated result, we analyse the change characteristics of the class-level metrics and landscape-level metrics. Our results show that the change trend in landscape can be effectively captured by spatial analysis using the remote sensing image and GIS data processing technique.
Development of a general‐purpose method for cell purification using Cre/loxP‐mediated recombination

A mammalian body is composed of more than 200 different types of cells. The purification of a certain cell type from tissues/organs enables a wide variety of studies. One popular cell purification method is immunological isolation, using antibodies against specific cell surface antigens. However, this is not a general‐purpose method, since suitable antigens have not been found in certain cell types, including embryonic gonadal somatic cells and Sertoli cells. To address this issue, we established a knock‐in mouse line, named R26 KI, designed to express the human cell surface antigen hCD271 through Cre/loxP‐mediated recombination. First, we used the R26 Kl mouse line to purify embryonic gonadal somatic cells. Gonadal somatic cells were purified from the R26 KI; Nr5a1‐Cre‐transgenic (tg) embryos almost equally as efficiently as from Nr5a1‐hCD271‐tg embryos. Second, we used the R26 KI mouse line to purify Sertoli cells successfully from R26 KI; Amh‐Cre‐tg testes. In summary, we propose that the R26 KI mouse line is a powerful tool for the purification of various cell types. genesis 53:387–393, 2015. © 2015 Wiley Periodicals, Inc.
Comparative studies of immunity proteins of pediocin-like bacteriocins.

Genes encoding pediocin-like bacteriocins are usually co-transcribed with a gene encoding a cognate immunity protein. To investigate the functionality and specificity of immunity proteins, immunity genes belonging to the bacteriocins curvacin A, enterocin A, enterocin P, leucocin A, pediocin PA-1 and sakacin P, as well as a putative immunity gene, orfY, were expressed in three bacteriocin-sensitive lactic acid bacteria (Lactobacillus sake, Carnobacterium piscicola and Enterococcus faecalis). The transformed indicator strains, each containing one of the immunity genes, were tested for sensitivity towards seven different purified bacteriocins (curvacin A, enterocin A, enterocin P, leucocin A, leucocin C, pediocin PA-1 and sakacin P). Cross-immunity was observed almost exclusively in situations where either the bacteriocins or the immunity proteins belonged to the same sequence-based subgroup. In a few cases, the functionality of immunity proteins was strain-dependent; e.g. the leucocin A immunity gene provided immunity to enterocin A, pediocin PA-1 and leucocin A in Ent. faecalis, whereas in the other two indicators, this gene provided immunity to leucocin A only. The orfY gene, which is transcribed without a cognate bacteriocin, was shown to encode a functional immunity protein that expands the bacteriocin resistance of the strain possessing this gene. The results show that the bacteriocin sensitivity of a lactic acid bacterium strain can depend on (1) the presence of immunity genes in connection with its own bacteriocin production, (2) the presence of extra immunity genes and (3) more general properties of the strain such as the membrane composition or the presence of receptors.
Components of Patient Satisfaction After Orthognathic Surgery

AbstractThe purpose of this study was to compare overall patient satisfaction after orthognathic surgery with the following specific categories: appearance, functional ability, general health, sociability, and patient–clinician communication. A 16-question survey was developed and administered to include patients at either 6 or 12 months after orthognathic surgery between June 2013 and June 2014 at the University of Pennsylvania and Massachusetts General Hospital. The predictor variables included age, sex, type of procedure, medical comorbidities, intra- or postoperative complications, and presence of paresthesia. The outcome variable was patient satisfaction overall and in each category based on a Likert scale (0: not satisfied at all to 5: very satisfied). A total of 37 patients completed the survey and had a high overall rate of satisfaction (100% of responses were 4 or 5 on Likert scale). Overall satisfaction had the highest correlation with appearance (&rgr; = 0.52, P = 0.0009) followed by sociability (&rgr; = 0.47, P = 0.004), patient–clinician communication (&rgr; = 0.38, P = 0.02) functionality (&rgr; = 0.19, P = 0.26), and general health (&rgr; = −0.11, P = 0.51). Patients had high satisfaction scores for orthognathic surgery. Satisfaction with postoperative appearance had the strongest correlation with overall satisfaction.
Clinical features and progression of perinatally acquired hepatitis C virus infection

The purpose of this prospective‐retrospective study was to provide information about the clinical features and progression of hepatitis C virus (HCV) infection transmitted perinatally. Seventy children born to HCV infected woman were enrolled consecutively in five European centers between 1990 and 1999, provided they had HCV RNA in the serum during the first year of life and/or were still anti‐HCV positive at 18 months. Sixty‐two infants were followed up to 24 months of age or more (range, 24 months–11 years; average, 4.8 ± 2.3 years). A wide range of ALT elevation was observed in 93% of the infants in the first year of life. During the follow‐up, a sustained ALT normalization with loss of HCV RNA was seen in 12/62 (19%) of the children within 30 months of life; 66% of the infants had developed an ALT peak greater than 5× normal at onset (vs. 28% of children with persistent viremia; P < 0.05), and 50% had HCV genotype 3 (vs. 17% of viremic children). Conversely the cumulative probability of chronic progression was 81%. Chronic infection was asymptomatic and liver disease was mild in all 11 children who underwent a biopsy. In conclusion the early stage of acquired perinatally HCV infection is characterized by a wide range of ALT abnormalities, suggesting the interaction of multiple host and virus factors. The chronic progression rate of infection is high, but the associated liver disease is usually mild. High ALT levels at onset seem to offer greater opportunity of biochemical remission and loss of viremia during follow‐up. J. Med. Virol. 70:373–377, 2003. © 2003 Wiley‐Liss, Inc.
Longevity, lignin content and construction cost of the assimilatory organs of Nepenthes species.

BACKGROUND AND AIMS This study examined level of causal relationships amongst functional traits in leaves and conjoint pitcher cups of the carnivorous Nepenthes species. METHODS Physico-chemical properties, especially lignin content, construction costs, and longevity of the assimilatory organs (leaf and pitcher) of a guild of lowland Nepenthes species inhabiting heath and/or peat swamp forests of Brunei, northern Borneo were determined. KEY RESULTS Longevity of these assimilatory organs was linked significantly to construction cost, lignin content and structural trait of tissue density, but these effects are non-additive. Nitrogen and phosphorus contents (indicators of Rubisco and other photosynthetic proteins), were poor predictors of organ longevity and construction cost, suggesting that a substantial allocation of biomass of the assimilatory organs in Nepenthes is to structural material optimized for prey capture, rigidity and escape from biotic and abiotic stresses rather than to light interception. Leaf payback time - a measure of net carbon revenue - was estimated to be 48-60 d. This is in line with the onset of substantial mortality by 2-3 months of tagged leaves in many of the Nepenthes species examined. However, this is a high ratio (i.e. a longer minimum payback time) compared with what is known for terrestrial, non-carnivorous plants in general (5-30 d). CONCLUSIONS It is concluded that the leaf trait bivariate relationships within the Nepenthes genus, as in other carnivorous species (e.g. Sarraceniaceae), is substantially different from the global relationship documented in the Global Plant Trait Network.
Utility of the PASS Theory and Cognitive Assessment System for Dutch Children With and Without ADHD

This study examined the utility of the Planning, Attention, Simultaneous, Successive (PASS) theory of intelligence as measured by the Cognitive Assessment System (CAS) for evaluation of children with attention-deficit/hyperactivity disorder (ADHD). The CAS scores of 51 Dutch children without ADHD were compared to the scores of a group of 20 Dutch children with ADHD. The scores of the Dutch children were also compared to American standardization samples of children with and without ADHD. The findings showed that children with ADHD in both countries demonstrated relatively low scores on the Planning and Attention scales of the CAS, but average scores on the Simultaneous and Successive scales. These findings are similar to previously published research suggesting that the PASS theory, as operationalized by the CAS, has sensitivity to the cognitive processing difficulties found in some children with ADHD.