Miracle-dz/UniFAR-FTUs huggingface dataset:
Wound detection and reconstruction using RGB-D camera

The advent of inexpensive RGB-D sensors pioneered by the original Kinect sensor, has paved the way for a lot of innovations in computer and robot vision applications. In this article, we propose a system which uses the new Kinect 2 sensor in a medical application for the purpose of detection and 3D reconstruction of chronic wounds. Wound detection is based on a per block classification of wound tissue using color histograms and the nearest neighbor approach. The 3D reconstruction is similar to KinectFusion where ICP is used for determining the rigid body transformation, color enhanced TSDF is applied for scene fusion, while the marching cubes algorithm is used for creating a surface mesh. The entire system is implemented in CUDA which enables real-time operation. The end result of the developed system is a precise 3D colored model which can be used for determining a correct therapy and treatment of chronic wounds.
Analysis of the bereavement effect after the death of a spouse in the Amish: a population-based retrospective cohort study

Objective This study investigates the association between bereavement and the mortality of a surviving spouse among Amish couples. We hypothesised that the bereavement effect would be relatively small in the Amish due to the unusually cohesive social structure of the Amish that might attenuate the loss of spousal support. Design Population-based cohort study. Setting The USA. Participants 10 892 Amish couples born during 1725–1900 located in Pennsylvania, Ohio and Indiana. All the participants are deceased. Outcome measures The survival time is ‘age’; event is ‘death’. Hazard ratios (HRs) of widowed individuals with respect to gender, age at widowhood, remarriage, the number of surviving children and time since bereavement. Results We observed HRs for widowhood ranging from 1.06 to 1.26 over the study period (nearly all differences significant at p<0.05). Mortality risks tended to be higher in men than in women and in younger compared with older bereaved spouses. There were significantly increased mortality risks in widows and widowers who did not remarry. We observed a higher number of surviving children to be associated with increased mortality in men and women. Mortality risk following bereavement was higher in the first 6 months among men and women. Conclusions We conclude that bereavement effects remain apparent even in this socially cohesive Amish community. Remarriage is associated with a significant decrease in the mortality risk among Amish individuals. Contrary to results from previous studies, an increase in the number of surviving children was associated with decreased survival rate.
TRIM3 Regulates the Motility of the Kinesin Motor Protein KIF21B

Kinesin superfamily proteins (KIFs) are molecular motors that transport cellular cargo along the microtubule cytoskeleton. KIF21B is a neuronal kinesin that is highly enriched in dendrites. The regulation and specificity of microtubule transport involves the binding of motors to individual cargo adapters and accessory proteins. Moreover, posttranslational modifications of either the motor protein, their cargos or tubulin regulate motility, cargo recognition and the binding or unloading of cargos. Here we show that the ubiquitin E3 ligase TRIM3, also known as BERP, interacts with KIF21B via its RBCC domain. TRIM3 is found at intracellular and Golgi-derived vesicles and co-localizes with the KIF21B motor in neurons. Trim3 gene deletion in mice and TRIM3 overexpression in cultured neurons both suggested that the E3-ligase function of TRIM3 is not involved in KIF21B degradation, however TRIM3 depletion reduces the motility of the motor. Together, our data suggest that TRIM3 is a regulator in the modulation of KIF21B motor function.
Organizational Creativity as an Attributional Process: The Case of Haute Cuisine

In this paper, we develop a framework that conceptualizes organizational creativity as an attributional process in which organizational creativity is constantly negotiated between an organization and its environment through ‘entre-relating activities’. Based on an empirical analysis of this process in the haute-cuisine restaurant Rutz in Berlin, we explore four entre-relating activities – surprising, satisfying, stimulating and savouring – through which ‘being creative’ and ‘being considered creative’ are set in relation to negotiate the attribution of organizational creativity. Our findings demonstrate how the sequential performance of these entre-relating activities is consequential for the gradual transition of external evaluations of an organization’s outcomes, from being considered ‘different’ to ‘one of a kind’, and thus the increasing attribution of organizational creativity over time. Our study contributes to the literature on organizational creativity by exploring the interplay between ‘being creative’ and ‘being considered creative’ through entre-relating activities, which is foundational for understanding organizational creativity. Furthermore, our findings put aesthetic responses at the centre of organizational creativity and demonstrate the playfulness of the process through which the attribution of organizational creativity is produced.
An Exploratory Study on Self-Admitted Technical Debt

Throughout a software development life cycle, developers knowingly commit code that is either incomplete, requires rework, produces errors, or is a temporary workaround. Such incomplete or temporary workarounds are commonly referred to as 'technical debt'. Our experience indicates that self-admitted technical debt is common in software projects and may negatively impact software maintenance, however, to date very little is known about them. Therefore, in this paper, we use source-code comments in four large open source software projects-Eclipse, Chromium OS, Apache HTTP Server, and ArgoUML to identify self-admitted technical debt. Using the identified technical debt, we study 1) the amount of self-admitted technical debt found in these projects, 2) why this self-admitted technical debt was introduced into the software projects and 3) how likely is the self-admitted technical debt to be removed after their introduction. We find that the amount of self-admitted technical debt exists in 2.4%-31% of the files. Furthermore, we find that developers with higher experience tend to introduce most of the self-admitted technical debt and that time pressures and complexity of the code do not correlate with the amount of self-admitted technical debt. Lastly, although self-admitted technical debt is meant to be addressed or removed in the future, only between 26.3%-63.5% of self-admitted technical debt gets removed from projects after introduction.
Mining Frequent Closed Itemsets from Highly Distributed Repositories

In this paper we address the problem of mining frequent closed itemsets in a highly distributed setting like a Grid. The extraction of frequent (closed) itemsets is an important problem in Data Mining, and is a very expensive phase needed to extract from a transactional database a reduced set of meaningful association rules, typically used for Market Basket Analysis. We figure out an environment where a transactional dataset is horizontally partitioned and stored in different sites. We assume that, due to the huge size of datasets and privacy concerns, dataset partitions cannot be moved to a centralized site where to materialize the whole dataset and perform the mining task. Thus it becomes mandatory to perform separate mining at each site, and then merge local results for deriving global knowledge. This paper shows how frequent closed itemsets, mined independently in each site, can be merged in order to derive globally frequent closed itemsets. Unfortunately, such merging might produce a superset of all the frequent closed itemsets, while the associated supports could be smaller than the exact ones because some globally frequent closed itemsets might be not locally frequent in some partition. In order to avoid an expensive post-processing phase, needed to compute exact global results, we employ a method to approximate the supports of closed itemsets. This approximation is only needed for those globally (closed) frequent itemsets which are locally infrequent on some dataset partitions, and thus are not returned at all from the corresponding sites.
Self-reported post-exertional fatigue in Gulf War veterans: roles of autonomic testing

To determine if objective evidence of autonomic dysfunction exists from a group of Gulf War veterans with self-reported post-exertional fatigue, we evaluated 16 Gulf War ill veterans and 12 Gulf War controls. Participants of the ill group had self- reported, unexplained chronic post-exertional fatigue and the illness symptoms had persisted for years until the current clinical study. The controls had no self-reported post-exertional fatigue either at the time of initial survey nor at the time of the current study. We intended to identify clinical autonomic disorders using autonomic and neurophysiologic testing in the clinical context. We compared the autonomic measures between the 2 groups on cardiovascular function at both baseline and head-up tilt, and sudomotor function. We identified 1 participant with orthostatic hypotension, 1 posture orthostatic tachycardia syndrome, 2 distal small fiber neuropathy, and 1 length dependent distal neuropathy affecting both large and small fiber in the ill group; whereas none of above definable diagnoses was noted in the controls. The ill group had a significantly higher baseline heart rate compared to controls. Compound autonomic scoring scale showed a significant higher score (95% CI of mean: 1.72–2.67) among ill group compared to controls (0.58–1.59). We conclude that objective autonomic testing is necessary for the evaluation of self-reported, unexplained post-exertional fatigue among some Gulf War veterans with multi-symptom illnesses. Our observation that ill veterans with self-reported post-exertional fatigue had objective autonomic measures that were worse than controls warrants validation in a larger clinical series.
Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling

The primary biological function of the endogenous cellular prion protein has remained unclear. We investigated its biological function in the generation of cellular immune responses using cellular prion protein gene-specific small interfering ribonucleic acid in vivo and in vitro. Our results were confirmed by blocking cellular prion protein with monovalent antibodies and by using cellular prion protein-deficient and -transgenic mice. In vivo prion protein gene-small interfering ribonucleic acid treatment effects were of limited duration, restricted to secondary lymphoid organs and resulted in a 70% reduction of cellular prion protein expression in leukocytes. Disruption of cellular prion protein signalling augmented antigen-specific activation and proliferation, and enhanced T cell receptor signalling, resulting in zeta-chain-associated protein-70 phosphorylation and nuclear factor of activated T cells/activator protein 1 transcriptional activity. In vivo prion protein gene-small interfering ribonucleic acid treatment promoted T cell differentiation towards pro-inflammatory phenotypes and increased survival of antigen-specific T cells. Cellular prion protein silencing with small interfering ribonucleic acid also resulted in the worsening of actively induced and adoptively transferred experimental autoimmune encephalomyelitis. Finally, treatment of myelin basic protein1–11 T cell receptor transgenic mice with prion protein gene-small interfering ribonucleic acid resulted in spontaneous experimental autoimmune encephalomyelitis. Thus, central nervous system autoimmune disease was modulated at all stages of disease: the generation of the T cell effector response, the elicitation of T effector function and the perpetuation of cellular immune responses. Our findings indicate that cellular prion protein regulates T cell receptor-mediated T cell activation, differentiation and survival. Defects in autoimmunity are restricted to the immune system and not the central nervous system. Our data identify cellular prion protein as a regulator of cellular immunological homoeostasis and suggest cellular prion protein as a novel potential target for therapeutic immunomodulation.
ToMaTo: a trustworthy code mashup development tool

Recent years have seen the emergence of a new programming paradigm for Web applications that emphasizes the reuse of external content, the mashup. Although the mashup paradigm enables the creation of innovative Web applications with emergent features, its openness introduces trust problems. These trust issues are particularly prominent in JavaScript code mashup -- a type of mashup that integrated external Javascript libraries to achieve function and software reuse. With JavaScript code mashup, external libraries are usually given full privileges to manipulate data of the mashup application and executing arbitrary code. This imposes considerable risk on the mashup developers and the end users. One major causes for these trust problems is that the mashup developers tend to focus on the functional aspects of the application and implicitly trust the external code libraries to satisfy security, privacy and other non-functional requirements. In this paper, we present ToMaTo, a development tool that combines a novel trust policy language and a static code analysis engine to examine whether the external libraries satisfy the non-functional requirements. ToMaTo gives the mashup developers three essential capabilities for building trustworthy JavaScript code mashup: (1) to specify trust policy, (2) to assess policy adherence, and (3) to handle policy violation. The contributions of the paper are: (1) a description of JavaScript code mashup and its trust issues, and (2) a development tool (ToMaTo) for building trustworthy JavaScript code mashup.
Model Checking of Concurrent Java Code

Since software is playing a vital role in our lives, the quality and reliability of software is of great concern. In general, the cost dedicated to software verification is significantly higher than its development cost. In the las tf ew decades, there has been a significant amount of work to develop di! erent software verification techniques. This paper gives a general overview of some of these techniques that can be applied to concurrent code. These techniques are compared with one another. Among these techniques, we are most interested in model checking. We specifically focus on model checking of concurrent code written in the Java programming language. This paper also explains the structure and features of a widely used model checker for Java code, Java PathFinder (JPF).
Microglia: An Active Player in the Regulation of Synaptic Activity

Synaptic plasticity is critical for elaboration and adaptation in the developing and developed brain. It is well established that astrocytes play an important role in the maintenance of what has been dubbed “the tripartite synapse”. Increasing evidence shows that a fourth cell type, microglia, is critical to this maintenance as well. Microglia are the resident macrophages of the central nervous system (CNS). Because of their well-characterized inflammatory functions, research has primarily focused on their innate immune properties. The role of microglia in the maintenance of synapses in development and in homeostasis is not as well defined. A number of significant findings have shed light on the critical role of microglia at the synapse. It is becoming increasingly clear that microglia play a seminal role in proper synaptic development and elimination.
Enterprise education: Towards a framework for effective engagement with the learners of today

Purpose The purpose of this paper is to examine young learners’ attitudes towards enterprise education within the context of a university led initiative to construct a sustainable framework which benefits identified stakeholders. Design/methodology/approach The research used self-completed questionnaires with 117 business studies students in Stages S4-S6 from secondary schools across Dundee and business students from Years 1-4 at one university in Dundee, Scotland. Findings The research reveals that respondents positively engage with enterprise education and felt that their project management, creative thinking, communication skills and confidence were enhanced by the activity of real-world business challenges. The findings support the notion that an enterprising spine embedded in the academic curriculum better equip the learner with the necessary hard and soft skills required for the employment market but not necessarily to be entrepreneurial. Research limitations/implications A limitation of this research was the sample size, which although representative of the pupil and student cohorts associated with the various stages of education being studied at the particular time of data collection, and is suitable for an exploratory study, the research would have benefited from being both larger and complimented by more of a qualitative component beyond the inclusion of open-ended questions. Practical implications As an exploratory study which informs a wider comparative study into enterprise education, the research examines learner’s perspectives and the measures they feel are required for effective engagement with enterprise education activities in schools and universities. The findings should assist education providers to deliver a better learning experience and the learners with improved enterprising and social skills, particularly the building of confidence. Social implications As an exploratory study which informs a wider comparative study into enterprise education, the research examines learner’s perspectives and the measures they feel are required for effective engagement with enterprise education activities in schools and universities. The findings should assist education providers to deliver a better learning experience and the learners with improved enterprising and social skills, particularly the building of confidence. Originality/value The research should prove useful to educational establishments who are considering the implementation of, or further engagement with, enterprise education and involvement with the business community and how such activities impact on their learners.
Control-flow Complexity Measurement of Processes and Weyuker's Properties

— Process measurement is the task of empirically and objectively assigning numbers to the properties of business processes in such a way as to describe them. Desirable attributes to study and measure include complexity, cost, maintainability, and reliability. In our work we will focus on investigating process complexity. We define process complexity as the degree to which a business process is difficult to analyze, understand or explain. One way to analyze a process’ complexity is to use a process control-flow complexity measure. In this paper, an attempt has been made to evaluate the control-flow complexity measure in terms of Weyuker’s properties. Weyuker’s properties must be satisfied by any complexity measure to qualify as a good and comprehensive one.
Nonmonotonic Reasoning With Web-Based Social Networks

A drawback of traditional default logic is that there is no general mechanism for preferring one default rule over another. To remedy this problem, numerous default logics augmented with priority relations have been introduced. In this paper, we show how trust values, derived from web-based social networks, can be used to prioritize defaults. We provide a coupling between the method for computing trust values in social networks given in [4] and the prioritized Reiter defaults of [1], where specificity of terminological concepts is used to prioritize defaults. We compare our approach with specificity-based prioritization, and discuss how the two can be combined. Finally, we show how our approach can be applied to other variants of prioritized default logic.
A systematic analysis of the effect of target RNA structure on RNA interference

RNAi efficiency is influenced by local RNA structure of the target sequence. We studied this structure-based resistance in detail by targeting a perfect RNA hairpin and subsequently destabilized its tight structure by mutation, thereby gradually exposing the target sequence. Although the tightest RNA hairpins were completely resistant to RNAi, we observed an inverse correlation between the overall target hairpin stability and RNAi efficiency within a specific thermodynamic stability (ΔG) range. Increased RNAi efficiency was shown to be caused by improved binding of the siRNA to the destabilized target RNA hairpins. The mutational effects vary for different target regions. We find an accessible target 3′ end to be most important for RNAi-mediated inhibition. However, these 3′ end effects cannot be reproduced in siRNA-target RNA-binding studies in vitro, indicating the important role of RISC components in the in vivo RNAi reaction. The results provide a more detailed insight into the impact of target RNA structure on RNAi and we discuss several possible implications. With respect to lentiviral-mediated delivery of shRNA expression cassettes, we present a ΔG window to destabilize the shRNA insert for vector improvement, while avoiding RNAi-mediated self-targeting during lentiviral vector production.
International Economic Review " Economics and Psychology " ? the Case of Hyperbolic Discounting *

The article questions the methodology of " economics and psychology " in its focus on the case of hyperbolic discounting. Using some experimental results, I argue that the same type of evidence, which rejects the standard constant discount utility functions, can just as easily reject hyperbolic discounting as well. Furthermore, a decision-making procedure based on similarity relations better explains the observations and is more intuitive. The article concludes that combining " economics and psychology " requires opening the black box of decision makers instead of modifying functional forms.
Linear Summation of Fractional-Order Matrices

Yeh and Pei presented a computation method for the discrete fractional Fourier transform (DFRFT) that the DFRFT of any order can be computed by a linear summation of DFRFTs with special orders. Based on their work, we investigate linear summation of fractional-order matrices in a general and comprehensive manner in this paper. We have found that for any diagonalizable periodic matrices, linear summation of fractional-order forms with special orders is related to the size and the period of the fractional-order matrix. Moreover, some properties and generalized results about linear summation of fractional-order matrices are also presented.
Probabilistic Models of Short and Long Distance Word Dependencies in Running Text

This article describes two complementary models that represent dependencies between words in local and non-local contexts. The type of local dependencies considered are sequences of part of speech categories for words. The non-local context of word dependency considered here is that of word recurrence, which is typical in a text. Both are models of phenomena that are to a reasonable extent domain independent, and thus are useful for doing prediction in systems using large vocabularies.