Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors predicting complication rates following total knee replacement.

BACKGROUND The purpose of this investigation was to expand on previous studies by more fully examining the role of a variety of patient and hospital characteristics in determining adverse outcomes following total knee replacement. METHODS With use of data from all hospital admissions in California from 1991 through 2001, multiple logistic regression was performed on the information regarding patients treated with total knee replacement. Rates of mortality and readmission due to infection and pulmonary embolism during the first ninety days after discharge were regressed against a variety of independent variables, including demographic factors (age, gender, race, ethnicity, and insurance type), burden of comorbid disease (Charlson comorbidity index), and provider variables (hospital size, teaching status, and surgical volume). A separate baseline probability analysis was then performed to compare the relative importance of all predictor variables. RESULTS The sample size for this analysis was 222,684. A total of 1176 deaths (rate, 0.53%), 1586 infections (0.71%), and 914 pulmonary emboli (0.41%) occurred within the first ninety days after discharge. The average age of the patients at the time of surgery was sixty-nine years. Sixty-two percent of the patients were women, and 32% had a Charlson comorbidity index of >0. The significant predictors for complications (p < 0.05) included age, gender, race/ethnicity, Charlson comorbidity index, insurance type, and hospital volume. A baseline probability analysis was performed with the base case considered to be a white woman who was over the age of sixty-five years, had a Charlson comorbidity index of 0, had Medicare insurance, and was treated at a high-volume, non-teaching hospital. For a patient with the baseline case characteristics, the probability of death was 31/10,000, the probability of infection was 59/10,000, and the probability of pulmonary embolism was 41/10,000 in the first ninety days after discharge. Altering the base case by assuming that care was received at a low-volume hospital increased the expected mortality rate by a factor of 26%. Increasing the Charlson comorbidity index to 1 increased the mortality rate by 170%, whereas decreasing the age to younger than sixty-five years lowered the mortality rate by 73%. Hospital volume, comorbidity, and age had similar effects on the expected rates of readmission due to infection and pulmonary embolism. CONCLUSIONS The effects of age and the Charlson comorbidity index on the baseline probability of adverse outcomes following total knee replacement were shown to be similar to or greater than the effect of hospital volume. This study elucidates and compares the relative importance of the effects of several different factors on outcome. This information is important when considering the conclusions and implications of this type of policy-relevant outcomes research.
Severe Obesity: Evidence for a Deranged Metabolic Program in Skeletal Muscle?

Severe obesity is increasing at a disproportionate rate compared with milder grade obesity. Our research group has obtained evidence indicative of an “obesity metabolic program” in skeletal muscles of severely obese individuals, which may be determined genetically or epigenetically. We believe that this represents a paradigm shift in thinking about metabolic regulation in obesity.
A Semantic Approach to the Extraction of Feature Terms

Understanding the meaning of a text depends on the knowledge the reader has about the topic addressed in a document, starting from the most complex concept to the simplest one. The representation of the knowledge is generally performed by ontologies, semantic networks, or typified by statistical algorithms able to organize the contents according to rules based on frequency of terms or synsets. The Opinion Mining is a way to go beyond text categorization through the analysis of the opinions related to a specific topic: a product, a service, a tourist location, etc. In this paper we propose to apply our experience in the semantic analysis of textual resources to the Opinion Mining task, with the aim to propose a different approach to the extraction of feature terms, performing a contextualisation by means of semantic categorisation, a semantic net of concept and by a set of qualities associated to the sense expressed by adjectives and adverbs.
The spectrum of levodopa‐related fluctuations in Parkinson's disease

One of the most common and difficult management problems in Parkinson’s disease (PD) is the development of a fluctuant response following treatment with levodopa. For most patients, these fluctuations take the form of variations in the severity of motor manifestations of PD, which are assumed to reflect changes in the availability and efficacy of dopamine in the striatum. ’X2 The proportion of patients with motor fluctuations (MF) increases with the duration of levodopa treatment, and the majority of PD patients develop MF within approximately 5 y e a r s a f t e r in i t ia t ion of levodopa MF are more common and occur sooner in patients who develop PD a t a younger age.6J The most commonly encountered form of fluctuating response is the predictable “wearing-off” of levodopa motor benefit, causing a transition from relative mobility (“on”) to increased parkinsonism (“off”), with a return to the “on” state after the next dose of levodopa. Many other forms of MF are recognized (table 11, and combinations of these features are frequent, especially in the later stages of PD . Although there has been considerable emphasis on these classic motor swings, a number of other types of fluctuations occur, many of a nonmotor nature, which may be equally, or more, incapacitating. We report selected patients who exhibited such relatively underappreciated fluctuations and attempt to organize these fluctuations into a rational classification.
Methylation-induced downregulation and tumor suppressive role of microRNA-29b in gastric cancer through targeting LASP1

MicroRNAs (miRs) have been demonstrated to play promoting or tumor suppressive roles in various human cancers, but the regulatory mechanism of miR-29b underlying gastric cancer development and progression still remains largely unclear. In the present study, we found that miR-29b was significantly downregulated in gastric cancer tissues and cell lines. Low expression of miR-29b was significantly associated with DNA methylation, and treatment with DNA methyltransferase inhibitor 5-Aza-20-deoxycytidine upregulated miR-29b in gastric cancer cells. In addition, both reduced miR-29b expression and miR-29b methylation were associated with disease progression and poor prognosis in gastric cancer. Restoration of miR-29b caused a reduction in gastric cancer cell proliferation, migration, and invasion, and inhibited tumor growth in vivo. LASP1 was then identified as a target gene of miR-29b in gastric cancer cells. Moreover, upregulation of LASP1 was significantly associated with gastric cancer progression and poor prognosis. Knockdown of LASP1 also suppressed the proliferation, migration, and invasion of gastric cancer cells. Moreover, overexpression of LASP1 impaired the suppressive effects of miR-29b on the malignant phenotypes of gastric cancer cells, suggesting that miR-29b may inhibit gastric cancer growth and metastasis via targeting LASP1. According to these data, miR-29b may be used as a potential therapeutic candidate for gastric cancer.
Improved air gap control using optimized antishock control algorithm for SIL-based near-field storage system

In this paper, the optimized anti-shock control algorithm is developed and implemented in an solid immersion lens (SIL)-based near-field (NF) storage systems to improve air gap control performance during dynamic conditions. Accordingly, to detect the stable gap error signal under continuous operating conditions, the air gap control performance must be increased to avoid collisions due to external shocks. In this study, we propose an anti-shock air gap control system using a double disturbance observer (DOB) and a dead-zone non-linear controller. Experimental results demonstrate that a double DOB with a dead-zone non-linear controller maintained the optical head with SIL optics for a 5.31 G@10 ms shock. Thus, the air gap control performance in the presence of external shocks was improved.
Simultaneous oxygenation and perfbsion imaging study of functional activity in primary visual cortex at different visual stimulation frequency: Quantitative correlation between BOLD and CBF changes

A relationship between regional cerebral blood flow (CBF) and blood oxygenation level dependent (BOLD) changes in the primary visual cortex (V1) at varied visual stimulation fre quency has been examined quantitatively using the multislice FAIR technique. A linear correlation in the common activation areas between functional BOLD and CBF maps was observed. This supports the hypothesis that the task‐stimulated BOLD changes in microvasculature are correlated with the CBF changes that presumably reflect the degree of neuronal ac tivity. The linear correlation coefficients for intrasubject com parisons are more significant than those for intersubject com parisons. This suggests that using intrasubject comparisons for quantitative studies of neuronal activity related to different task stimuli and task performances should be more reliable than using intersubject comparisons.
Early Life Socioeconomic Status and Late Life Risk of Alzheimer’s Disease

The authors examined the relation of early life socioeconomic status to incident Alzheimer’s disease (AD), level of cognition and rate of cognitive decline in old age. For up to 10 years, 859 older Catholic clergy members without dementia at baseline completed annual clinical evaluations as part of the Religious Orders Study. The evaluations included clinical classification of AD and detailed cognitive testing. At baseline, indicators of early life household socioeconomic level (e.g., parental education) and the county of birth were ascertained. Socioeconomic features of the birth county (e.g., literacy rate) were estimated with data from the 1920 US Census. Composite measures of early life household and community socioeconomic level were developed. In analyses that controlled for age, sex and education, higher household and community socioeconomic levels in early life were associated with higher level of cognition in late life but not with risk of AD or rate of cognitive decline. The results suggest that early life socioeconomic level is related to level of cognition in late life but not to rate of cognitive decline or risk of AD.
An optimized method to separate reticulocytes from peripheral blood for molecular analysis

A method based on immunomagnetic sorting of reticulocytes from peripheral blood was set up and combined to a commercial extraction kit for the isolation of total RNA from whole blood. This procedure resulted in high‐quality RNA samples suitable for molecular analysis. We used this procedure to analyse erythroid‐specific transcripts, starting from peripheral blood samples, to search for differently expressed mRNAs in patients with hereditary persistence of foetal haemoglobin. After erythrocyte lysis, CD15+and CD45+ peripheral cells were negatively sorted to remove leucocyte populations that could have affected the subsequent screening procedure. The cell sorting and RNA extraction procedure was completed within 1–2 h of erythrocyte lysis, which represents a consistent saving of time compared with other procedures. Moreover, it produced 1 μg of total RNA per ml of blood samples, which is sufficient for molecular analysis. Therefore, our method is a reliable and efficient tool to isolate RNA from specific cell subpopulations poorly represented in peripheral blood, particularly when accurate detection and characterization of highly unstable and poorly expressed molecules is required.
Control methodologies for upper limb exoskeleton robots

An exoskeleton robot is kind of a man-machine system which mostly uses combination of human intelligence and machine power. These robotic systems are used for different applications such as rehabilitation, human power amplification, motion assistance, virtual reality etc. Successful operation of an exoskeleton robot depends on correct selection of design and control methodologies. This paper reviews control methodologies used in upper limb exoskeleton robots. In the review, the control methods used in the exoskeleton robots are classified into three categories: control system based on human biological signal, nonbiological signal and platform independent control system. Different types of control methods under each category are compared and reviewed.
PCH1 integrates circadian and light-signaling pathways to control photoperiod-responsive growth in Arabidopsis

Plants react to seasonal change in day length through altering physiology and development. Factors that function to harmonize growth with photoperiod are poorly understood. Here we characterize a new protein that associates with both circadian clock and photoreceptor components, named PHOTOPERIODIC CONTROL OF HYPOCOTYL1 (PCH1). pch1 seedlings have overly elongated hypocotyls specifically under short days while constitutive expression of PCH1 shortens hypocotyls independent of day length. PCH1 peaks at dusk, binds phytochrome B (phyB) in a red light-dependent manner, and co-localizes with phyB into photobodies. PCH1 is necessary and sufficient to promote the biogenesis of large photobodies to maintain an active phyB pool after light exposure, potentiating red-light signaling and prolonging memory of prior illumination. Manipulating PCH1 alters PHYTOCHROME INTERACTING FACTOR 4 levels and regulates light-responsive gene expression. Thus, PCH1 is a new factor that regulates photoperiod-responsive growth by integrating the clock with light perception pathways through modulating daily phyB-signaling. DOI: http://dx.doi. org/10.7554/eLife.13292. 001
Injury Patterns After the Landslide Disaster in Oshima, Tokyo, Japan on October 16, 2013

Abstract Introduction Landslides represent a frequent and threatening natural disaster. The aim of this study was to investigate the injury patterns observed after a landslide and to discuss how to minimize the damage caused by a landslide disaster. Methods A landslide occurred on Oshima Island, Japan, on October 16, 2013. A total of 49 victims with landslide-related injuries were identified and analyzed. Results The patients ranged in age from 5 to 89 years with an average age of 61.0±19.3 years. Of all patients, 69.4% were triaged as black. Of 15 patients who were treated in the nearest hospital (the only hospital on the island), 8 were triaged as red and yellow with severe chest or pelvic injury and a high Injury Severity Score (average score, 25.6; range, 4–45). Of these, 75% had chest injury and 75% had pelvic injury. The percentage of chest and/or pelvic injury was 100% in patients triaged as red or yellow. Traumatic asphyxia was diagnosed in 62.5% of these patients. Conclusions Compression of the trunk was the main injury in patients triaged as red or yellow after this landslide disaster. Evacuation in advance, the rapid launch of emergency medical support, and knowledge of this specific injury pattern are essential to minimize the potential damage resulting from landslide disasters. (Disaster Med Public Health Preparedness. 2016;10:248–252)
ANESTHESIA OF THE LARYNX IN THE PATIENT WITH A FULL STOMACH.

In the past decade a number of communications have been written concerning the danger of aspiration during the induction of general anesthesia in patients with full stomachs. 1-7 A review of the many techniques recommended to avoid this complication has been published recently by Weaver. 7 One of the frequently proposed safety measures is the insertion of a cuffed endotracheal tube prior to the induction of anesthesia. Although intubation performed with the patient awake certainly is one of the more reliable methods of avoiding aspiration, exception must be taken to the technique usually described for inserting the tube. It has been suggested that topical anesthesia of the larynx and trachea be performed to facilitate intubation of the adult patient. Though anesthesiologists differ as to whether percutaneous, 7,8 transoral, 1 or superior laryngeal block 5 should be used, they nevertheless agree that surface anesthesia of the laryngeal and tracheal mucosa is
Antibiotic susceptibility and serotype distribution of Streptococcus pneumoniae in Malaysian children.

Pendant 1 an etude de l'etiologie des infections respiratoires aigues chez des enfants de moins de 5 ans. Isolement de 250 souches de pneumocoques des aspirats rhinopharynges. Etude de la sensibilite a 5 antibiotiques. On observe 2% de resistance a la penicilline, 0,8% a l'erythromycine, 0,4% a la cephalosporine, 3,4% a la lincomycine et 18,4% a la tetracycline. Seulement 2 souches sont resistantes a plus de 2 antibiotiques
RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation

Glioblastoma multiforme (GBM) is the most aggressive and lethal type of brain tumor. Standard treatment for GBM patients is surgery followed by radiotherapy and/or chemotherapy, but tumors always recur. Traditional therapies seem to fail because they eliminate only the bulk of the tumors and spare a population of stem-like cells termed tumor-initiating cells. The stem-like state and preferential activation of DNA damage response in the GBM tumor-initiating cells contribute to their radio-resistance and recurrence. The molecular mechanisms underlying this efficient activation of damage response and maintenance of stem-like state remain elusive. Here we show that RBM14 controls DNA repair pathways and also prevents cell differentiation in GBM spheres, causing radio-resistance. Knockdown of RBM14 affects GBM sphere maintenance and sensitizes radio-resistant GBM cells at the cellular level. We demonstrate that RBM14 knockdown blocks GBM regrowth after irradiation in vivo. In addition, RBM14 stimulates DNA repair by controlling the DNA-PK-dependent non-homologous end-joining (NHEJ) pathway. These results reveal unexpected functions of the RNA-binding protein RBM14 in control of DNA repair and maintenance of tumor-initiating cells. Targeting the RBM14-dependent pathway may prevent recurrence of tumors and eradicate the deadly disease completely.
A Mobile Service Robot for Industrial Applications

This paper addresses the challenge of introducing mobile robots in industrial applications, where changes in the working environment and diversification of tasks require flexibility, adaptability and in some cases basic reasoning capabilities. Classical industrial robots hardly permit to meet these requirements, so a new concept of service robots facing challenging industrial production system needs is proposed. The realization of such an autonomous agent is illustrated and described in details, focusing on mobility, environmental perception and manipulation capabilities. The result is a mobile service robot able to face changeable conditions as well as unexpected situations and different kinds of manipulation tasks in industrial environments. In this paper an implementation dedicated to household appliances production is described, but the results achieved can be easily extended to many industrial sectors, goods and electromechanical components where high levels of flexibility and autonomy are needed.
Cloud Security Engineering: Theory, Practice and Future Research

The eleven papers in this special issue address security and privacy concerns associated with cloud computing. This special issue is dedicated to the identification of techniques that enable security mechanisms to be engineered and implemented in cloud services and cloud systems. A key focus is on the integration of theoretical foundations with practical deployment of security strategies that make cloud systems more secure for both end users and providers – enabling end users to increase the level of trust they have in cloud service providers – and conversely for cloud service providers to provide greater guarantees to end users about the security of their services and data.
Desarrollo de un entorno virtual para la inducción emocional

Los entornos virtuales se han mostrado de gran ayuda en las tecnicas de induccion emocional planteadas por la psicologia clinica. Sin embargo la complejidad, el coste y el acceso a las tecnologias a menudo han supuesto un obstaculo considerable para desarrollar este tipo de herramientas. Aprovechando las el incremento de las herramientas y tecnologias que dan soporte a la creacion de este tipo de contenidos se ha desarrollado un entorno virtual cuyo objetivo es la induccion de alegria. Este trabajo muestra el proceso de desarrollo de este sistema y los componentes virtuales que han sido incluidos asi como su inclusion en un navegador para facilitar el acceso a los contenidos creados.
Electroconvulsive therapy: A comparison of seizure duration as monitored with electroencephalograph and electromyograph

EEG and EMG were monitored simultaneously at 72 ECT sessions in 18 patients. When EMG was recorded from the leg the duration of EMG curve convulsions varied between 43 and 89 % of the EEG recorded seizure duration of the same fit. The EMG/EEG seizure ratio varied widely among different patients as well as within the single patient during a series of ECT sessions. EMG recording from the masseter muscles showed EMG seizure duration to be more in accordance with the EEG seizure duration than EMG recordings from the leg. The EMG/EEG seizure ratio (masseter) varied from 65 to 100 %, which was significantly higher than the EMG/EEG seizure ratio obtained with EMG recorded from the calf muscles.
Postinfarct Left Ventricular Remodelling: A Prevailing Cause of Heart Failure

Heart failure is a chronic disease with high morbidity and mortality, which represents a growing challenge in medicine. A major risk factor for heart failure with reduced ejection fraction is a history of myocardial infarction. The expansion of a large infarct scar and subsequent regional ventricular dilatation can cause postinfarct remodelling, leading to significant enlargement of the left ventricular chamber. It has a negative prognostic value, because it precedes the clinical manifestations of heart failure. The characteristics of the infarcted myocardium predicting postinfarct remodelling can be studied with cardiac magnetic resonance and experimental imaging modalities such as diffusion tensor imaging can identify the changes in the architecture of myocardial fibers. This review discusses all the aspects related to postinfarct left ventricular remodelling: definition, pathogenesis, diagnosis, consequences, and available therapies, together with experimental interventions that show promising results against postinfarct remodelling and heart failure.
Novel Apidaecin 1 b Analogs with Superior Serum Stabilities for Treatment of Infections by Gram-Negative Pathogens

Nicole Berthold, Patricia Czihal, Stefanie Fritsche, Ute Sauer, Guido Schiffer, Daniel Knappe, Gottfried Alber, Ralf Hoffmann Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, Universität Leipzig, Leipzig, Germany; Center for Biotechnology and Biomedicine, Universität Leipzig, Leipzig, Germany; Institute of Immunology, College of Veterinary Medicine, Universität Leipzig, Leipzig, Germany; AiCuris GmbH & Co. KG, Wuppertal, Germany