Miracle-dz/UniFAR-FTUs huggingface dataset:
Methods for estimating the autocorrelation function of complex Gaussian stationary processes

New methods for estimating the autocorrelation function (acf) of a complex Gaussian stationary process are presented. These methods are based on a general invariance property for the autocorrelation of a common class of the above processes. This property suggests estimation procedures based on magnitude hard limiting and phase quantization. The procedures are an extension of the relay estimator, currently employed for real processes. The computational cost and the general properties of the methods are discussed. In particular, some estimators especially suited for very simple implementations are considered. The performance of the complex hybrid sign estimator is evaluated and compared to that of the classical Direct estimator. The proposed methods are attractive for many applications in the field of digital signal processing.
WO3/Pt nanoparticles are NADPH oxidase biomimetics that mimic effector cells in vitro and in vivo

To provide a means of delivering an artificial immune effector cell-like attack on tumor cells, we report the tumoricidal ability of inorganic WO3/Pt nanoparticles that mimic a leukocyte’s functional abilities. These nanoparticles route electrons from organic structures and electron carriers to form hydroxyl radicals within tumor cells. During visible light exposure, WO3/Pt nanoparticles manufacture hydroxyl radicals, degrade organic compounds, use NADPH, trigger lipid peroxidation, promote lysosomal membrane disruption, promote the loss of reduced glutathione, and activate apoptosis. In a model of advanced breast cancer metastasis to the eye’s anterior chamber, we show that WO3/Pt nanoparticles prolong the survival of 4T1 tumor-bearing Balb/c mice. This new generation of inorganic photosensitizers do not photobleach, and therefore should provide an important therapeutic advance in photodynamic therapy. As biomimetic nanoparticles destroy targeted cells, they may be useful in treating ocular and other forms of cancer.
TrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance in multiple myeloma through NF-кβ inhibition

ABSTRACT Multiple myeloma (MM) is a B-cell malignancy characterized by an accumulation of abnormal clonal plasma cells in the bone marrow. Introduction of the proteasome-inhibitor bortezomib has improved MM prognosis and survival; however hypoxia-induced or acquired bortezomib resistance remains a clinical problem. This study highlighted the role of thioredoxin reductase 1 (TrxR1) in the hypoxia-induced and acquired bortezomib resistance in MM. Higher TrxR1 gene expression correlated with high-risk disease, adverse overall survival, and poor prognosis in myeloma patients. We demonstrated that hypoxia induced bortezomib resistance in myeloma cells and increased TrxR1 protein levels. Inhibition of TrxR1 using auranofin overcame hypoxia-induced bortezomib resistance and restored the sensitivity of hypoxic-myeloma cells to bortezomib. Hypoxia increased NF-кβ subunit p65 nuclear protein levels and TrxR1 inhibition decreased hypoxia-induced NF-кβ p65 protein levels in the nucleus and reduced the expression of NF-кβ-regulated genes. In addition, higher TrxR1 protein levels were observed in bortezomib-resistant myeloma cells compared to the naïve cells, and its inhibition using either auranofin or TrxR1-specific siRNAs reversed bortezomib resistance. TrxR1 inhibition reduced p65 mRNA and protein expression in bortezomib-resistant myeloma cells, and also decreased the expression of NF-кβ-regulated anti-apoptotic and proliferative genes. Thus, TrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance by inhibiting the NF-кβ signaling pathway. Our findings demonstrate that elevated TrxR1 levels correlate with the acquisition of bortezomib resistance in MM. We propose considering TrxR1-inhibiting drugs, such as auranofin, either for single agent or combination therapy to circumvent bortezomib-resistance and improve survival outcomes of MM patients.
Plasmon enhanced power conversion efficiency in inverted bulk heterojunction organic solar cell

P3HT:PCBM is one of the most studied polymer-fullerene system. However the reported power conversion efficiency (PCE) values falls within the range of 4% to 5%. The thin film architecture in OPVs exhibits low PCE compared to inorganic photovoltaic cells. This is mainly due to the low exciton diffusion length that limits the active layer thickness which in turn reduces the absorption of incident light. Several strategies are adapted in order to increase the absorption in the active layer without increasing the film thickness. Inclusion of metal nanoparticles into the polymer layer of bulk heterojunction (BHJ) solar cells is one of the promising methods. Incorporation of metal nanostructures increases the absorption of organic materials due to the high electromagnetic field strength in the vicinity of the excited surface plasmons. In this work, we used ~ 60 nm Au plasmonic structures to improve the efficiency of organic solar cell. The prepared metal nano structures were characterized through scanning electron microscopy (SEM), and UV-Visible spectroscopy techniques. These prepared metallic nanoparticles can be incorporated either into the electron transport layer (ETL) or into the active P3HT:PC71BM layer. The effect of incorporation of plasmonic gold (Au) nanoparticle in the inverted bulk heterojunction organic photovoltaic cells (OPVs) of P3HT:PC71BM fabricated in ambient air condition is in progress. Initial studies shows an 8.5% enhancement in the PCE with the incorporation of Au nanoparticles under AM1.5G light of intensity 1 Sun.
SVM detection of epileptiform activity in routine EEG

Routine electroencephalogram (EEG) is an important test in aiding the diagnosis of patients with suspected epilepsy. These recordings typically last 20–40 minutes, during which signs of abnormal activity (spikes, sharp waves) are looked for in the EEG trace. It is essential that events of short duration are detected during the routine EEG test. The work presented in this paper examines the effect of changing a range of input values to the detection system on its ability to distinguish between normal and abnormal EEG activity. It is shown that the length of analysis window in the range of 0.5s to 1s are well suited to the task. Additionally, it is reported that patient specific systems should be used where possible due to their better performance.
Performance Analysis of Preamble-Based TDMA Protocol for Wireless Body Area Network

A wireless body area network (WBAN) allows the integration of low power, invasive or non-invasive miniaturized sensors around a human body. Each intelligent sensor has enough capability to analyze and process the physiological parameters and to forward all the information to a central intelligent node for disease management, diagnosis and prescription. The data transmission rate of various biosensors is heterogeneous. Furthermore, the limited energy resources and computational power of these sensors have urged the development of low power energy efficient medium access control (MAC) protocol. This paper studies the performance of Preamble-Based time division multiple access (PB-TDMA) protocol for a heterogeneous non-invasive WBAN. Simulation results show that the performance of PB-TDMA protocol outperforms S-MAC and IEEE 802.11 DCF in terms of throughput and power consumption.
Aptamers and Glioblastoma: Their Potential Use for Imaging and Therapeutic Applications

Glioblastoma is a highly aggressive primary brain tumour, renowned for its infiltrative growth and varied genetic profiles. The current treatment options are insufficient, and their off-target effects greatly reduce patient quality of life. The major challenge in improving glioblastoma diagnosis and treatment involves the development of a targeted imaging and drug delivery platform, capable of circumventing the blood brain barrier and specifically targeting glioblastoma tumours. The unique properties of aptamers demonstrate their capability of bridging the gap to the development of successful diagnosis and treatment options, where antibodies have previously failed. Aptamers possess many characteristics that make them an ideal novel imaging and therapeutic agent for the treatment of glioblastoma and other brain malignancies, and are likely to provide patients with a better standard of care and improved quality of life. Their target sensitivity, selective nature, ease of modification and low immunogenicity make them an ideal drug-delivery platform. This review article summarises the aptamers previously generated against glioblastoma cells or its identified biomarkers, and their potential application in diagnosis and therapeutic targeting of glioblastoma tumours.
ANTI-QUORUM SENSING ACTIVITY OF SOME MEDICINAL PLANTS

Background: Quorum sensing is the key regulator of virulence factors of Pseudomonas aeruginosa such as biofilm formation, motility, productions of proteases, hemolysin, pyocyanin, and toxins. The aim of this study was to explore the effect of the extracts from some medicinal plants on quorum sensing and related virulence factors of P. aeruginosa. Material and Methods: Quorum sensing inhibitory (OSI) effect of the alcohol extracts of 20 medicinal plants was evaluated by Chromobacterium violaceum reporter using agar cup diffusion method. The efficient QSI extracts were tested for their activity against biofilm synthesis, motility, and synthesis of pyocyanin from P. aeruginosa PA14 Results: The extracts of Citrus sinensis, Laurus nobilis, Elettaria cardamomum, Allium cepa, and Coriandrum sativum exhibited potent quorum quenching effect. On the other hand, Psidium guajava and Mentha longifolia extracts showed lower QSI activity. These extracts exhibited significant elimination of pyocyanin formation and biofilm development of Pseudomonas aeruginosa PA14. In addition, they significantly inhibited twitching and swimming motilities of P. aeruginosa PA14. Conclusion: This study illustrated, for the first time, the importance of C. sinensis, L. nobilis, E. cardamomum, A. cepa, and C. sativum as quorum sensing inhibitors and virulence suppressors of P. aeruginosa. Thus, these plants could provide a natural source for the elimination of Pseudomonas pathogenesis.
Phonological theory and the development of prosodic structure: Evidence from child Japanese

This article presents a model of prosodic structure development that takes account of the fundamental continuity between child and adult systems, the surface level divergence of child forms from their adult target forms, and the overall developmental paths of prosodic structure. The main empirical base for the study comes from longitudinal data collected from three Japanese-speaking children (1; 0–2; 6). Evidence for word-internal prosodic constituents including the mora and the foot is found in compensatory lengthening phenomena, syllable size restrictions and word size restrictions in early word production. By implementing the representational principles that organize these prosodic categories as rankable and violable constraints, Optimality Theory can provide a systematic account of the differences in the prosodic structure of child and adult Japanese while assuming representational continuity between the two. A constraint-based model of prosodic structure acquisition is also shown to demarcate the learning paths in a way that is consistent with the data.
Nonlinear System Identification Using a Neo Fuzzy Neuron Algorithm: Electrical Drive Application

This work presents a Neo-Fuzzy-Neuron algorithm for the identification of nonlinear dynamic systems at the point of view of a rotor flux observer. The algorithm training is on-line, has low computational cost, does not require previous training and its convergence in one step is proved. The gradient descent method is used for its weights adjustment. Simulation and experimental results demonstrate the effectiveness of the algorithm for flux observer of induction motor drive system.
Inter-rater reliability of a musculoskeletal screen as administered to female professional contemporary dancers.

OBJECTIVE The purpose of this study is to determine the inter-rater reliability of commonly used musculoskeletal screening components in a population of contemporary professional dancers. PARTICIPANTS Study participants were 30 women from six contemporary dance companies between the ages of 18 and 32, with a mean age of 24, and Body Mass Index of 22.4. METHODS 101 items were assessed in the categories of Static Posture, the Beighton 9-Point Hypermobility Test, Flexibility, Strength, and Dynamic Posture, based upon the Pilot 2006 Dance USA Annual Post-Hire Health Screen for Professional Dancers. Testing was non-ordered, using 2 of the 4 available testers, with variable assignment of the lead tester. RESULTS High percent agreement was found for the subcategories of hallux valgus, pelvic tilt, and forefoot alignment, flexor hallucis, iliopsoas, hip internal rotation flexed, external rotation extended, and soleus extensibility, composite Beighton, and for most measures within the dynamic posture category. Low to moderate percent agreement was found in the strength tests. CONCLUSION Although this study demonstrated moderate to high percent agreement between raters, further test refinement is needed to improve the reliability of the measurement components.
Health‐related quality of life in subjects with HCV/HIV coinfection: results from ACTG 5178 study

Summary. Although health‐related quality of life (HRQOL) is diminished in HCV/HIV, the relationship between virologic response and maintenance therapy with HRQOL in this population is unknown. ACTG 5178 was a phase 2, randomized trial, with three steps – Step 1: all subjects received pegylated interferon (PEG‐IFN)/ribavirin (P/R) for 12 weeks. Step 2: subjects who failed to achieve early viral response (EVR) were randomized to PEG‐IFN or observational control for an additional 72 weeks. Step 3: subjects with EVR from step 1 continued on P/R for a total of 72 weeks with 24 weeks follow‐up off‐therapy. HRQOL, symptom distress and depression levels were measured at multiple time points. In step 1 (n = 329), there was a significant decline in HRQOL in all dimensions. In step 3 (n = 169), the overall HRQOL and three of its eight dimensions (general health, role function and pain score) were increased, and achievement of sustained virologic response was associated with increased general health and cognitive function. In step 2 (n = 85), there was no significant change in HRQOL and no significant difference between groups (PEG‐IFN vs observational control). There was a significant decline in HRQOL during the initial 12 weeks of therapy. Thereafter, the HRQOL profile differed for subjects with EVR vs without EVR. Maintenance therapy with PEG‐IFN had no impact on the HRQOL.
Clinical utility of BOLD fMRI in preoperative work-up of epilepsy

Abstract Surgical techniques have emerged as a viable therapeutic option in patients with drug refractory epilepsy. Pre-surgical evaluation of epilepsy requires a comprehensive, multiparametric, and multimodal approach for precise localization of the epileptogenic focus. Various non-invasive techniques are available at the disposal of the treating physician to detect the epileptogenic focus, which include electroencephalography (EEG), video-EEG, magnetic resonance imaging (MRI), functional MRI including blood oxygen level dependent (BOLD) techniques, single photon emission tomography (SPECT), and 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET). Currently, non-invasive high-resolution MR imaging techniques play pivotal roles in the preoperative detection of the seizure focus, and represent the foundation for successful epilepsy surgery. BOLD functional magnetic resonance imaging (fMRI) maps allow for precise localization of the eloquent cortex in relation to the seizure focus. This review article focuses on the clinical utility of BOLD (fMRI) in the pre-surgical work-up of epilepsy patients.
Panoramic representation of scenes for route understanding

A dynamically generated panoramic representation for route recognition by a mobile robot is presented. The strategies employed are route description from experience and route recognition by visual information. In the description phase, panoramic representation, a representation of scenes along a route, is proposed. It is obtained by scanning scenes sideways along the route, which provides rich information, such as a 2-D projection of scenes called panoramic view, a path-oriented 2-1/2-D sketch, and a path description. The continuous panoramic view is more efficient in processing than integrating discrete views into a complete route model. In the recognition phase, the robot matches the panoramic representation from incoming images with that memorized in the previous scan so that it can locate and orient itself in autonomous navigation. Since the panoramic view covers a wide field of view, one can achieve reliable matching using a coarse-to-fine method, starting from a very coarse level. <<ETX>>
Expert Systems and Special Education

Expert systems are computer programs designed to replicate human expertise in a variety of areas. This article discusses the characteristics of these programs as well as recently available expert system development tools. The article also suggests potential applications for expert systems within the field of special education. Finally, the article reviews recent efforts to apply expert systems technology to special education problems.
Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention

Objective: Restenosis is the main drawback of percutaneous coronary intervention (PCI). Inherited factors may explain part of the risk of restenosis. Recently, the vitamin D receptor (VDR) has been shown to be involved not only in bone metabolism but also in modulating immune responses and cell proliferation. Since the inflammatory response is implicated in restenosis, VDR-gene variants could therefore contribute to the risk of restenosis. Methods/results: Systematic genotyping for 15 haplotype tagging single-nucleotide polymorphisms (SNPs) of the VDR gene was performed with the high throughput TaqMan allelic discrimination assays in the Genetic Determinants of Restenosis (GENDER) population. A haplotype-based survival analysis revealed an association of haplotypes in blocks 2, 3 and 4 of the VDR-gene with the risk of clinical restenosis (p-values 0.01, 0.04 and 0.02 respectively). After adjustment for clinical risk factors for restenosis, the individual effect of the block 2 AA haplotype (p = 0.011) persisted. Conclusions: The present study indicates that VDR plays a role in restenosis after PCI. Therefore, VDR genotype may be used as risk marker for restenosis and may contribute to individual patient screening prior to PCI in clinical practice.
The Effects of Expressive Writing on Postpartum Depression and Posttraumatic Stress Symptoms

This study investigated whether an Expressive Writing intervention decreased depression and posttraumatic stress symptoms after childbirth. 113 women (M age = 31.26 yr., SD = 4.42) were assessed at Time 1 for depression (Beck Depression Inventory) and PTS (Perinatal PTSD Questionnaire) in the first days after childbirth, then randomized to either expressive writing or neutral writing conditions and reassessed at Time 2, 3 months later. The results (ANCOVAs, regression models) show that at 3 mo. depressive and posttraumatic symptoms were lower in women who performed the expressive writing task than in the neutral writing group. Moreover, the intervention condition was associated significantly with decreased depression at the high and at the mean levels of baseline depression at Time 1. Regarding PTSD, the results showed that the intervention condition was linked significantly to reductions of the symptoms at all levels of baseline PTSD. Mainly, these outcomes suggest that Expressive Writing can be a helpful early and low-cost universal intervention to prevent postpartum distress for women.
Educational differences in cardiovascular mortality: The role of shared family factors and cardiovascular risk factors

Aims: To explore the confounding effects of early family factors shared by siblings and cardiovascular risk factors in midlife on the educational differences in mortality from cardiovascular disease (CVD). Methods: Data from national and regional health surveys in Norway (1974–2003) were linked with data from the Norwegian Family Based Life Course Study, the National Educational Registry and the Cause of Death Registry. The study population consisted of participants with at least one full sibling among the health survey participants (n=271,310). Data were available on CVD risk factors, including weight, height, blood pressure, total cholesterol and smoking. Results: The hazards ratio (HR) of CVD mortality was 3.44 (95% confidence interval (CI) 2.98–3.96) in the lowest educational group relative to the highest. The HRs were little altered in the within-sibship analyses. Adjusted for risk factors, the HR for CVD mortality in the cohort analyses was 2.05 (CI 1.77–2.37) in the lowest educational group relative to the highest. The respective HR in the within-sibship analyses was 2.46 (CI 1.48–2.24). Conclusions: Using a sibling design, we did not find that the association between education and CVD mortality was confounded by early life factors shared by siblings, but it was explained to a large extent by CVD risk factors. These results suggest that reducing levels of CVD risk factors could have the greatest effect on mortality in less well-educated people.
Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor‐β1 in cultured cardiac fibroblasts

Transforming growth factor‐β1 (TGF‐β1) and endoglin play a causal role in promoting cardiac fibrosis. Atorvastatin has been shown to have an inhibitory effect on cardiac fibroblasts in vitro. However, the effects of statins on TGF‐β1 and endoglin are poorly understood. We therefore sought to investigate the molecular mechanisms of atorvastatin on endoglin expression after TGF‐β1 stimulation in cardiac fibroblasts.
Prevalence of alcohol use disorders in mainland China: a systematic review

Abstract Aims To identify studies about the prevalence of alcohol use disorder (AUD) in mainland China, evaluate the quality of these studies and conduct a meta‐analysis of the prevalence of AUD in China's adult population and in population subgroups defined by sex, age and urban versus rural residency. Methods Relevant studies published prior to January 2014 were identified from the following databases: China Knowledge Resource Integrated (CNKI), Wanfang, Pubmed, EmBase and Web of Science. A 16‐item quality assessment inventory for epidemiological studies in mainland China was constructed to evaluate the methodological rigor of the studies. A total of 38 studies including 1 304 354 individuals were identified. Outcomes included current and life‐time prevalence of AUD, alcohol dependence and alcohol abuse. Results The pooled life‐time and current prevalence of alcohol dependence were 1.4% [95% confidence interval (CI) = 1.3, 1.5] and 1.5% (95% CI = 1.2, 1.9). For males, pooled estimates of the current prevalence of alcohol dependence, alcohol abuse and AUD were 4.4 (95% CI = 3.1, 5.7), 4.0 (95% CI = 2.2, 5.7) and 10.1% (95% CI = 4.7, 15.4), respectively; the corresponding values for females were all below 0.2, 0.1, and 0.1%. There was large between‐study heterogeneity in the prevalence measures that was associated with sample size, the use of key informants and the use of substitute respondents. The quality of included studies was generally low. Higher‐quality studies reported higher prevalence. Conclusions Alcohol use disorder is an urgent public health problem in China, especially among males. When using high‐quality studies, current and life‐time prevalence estimates of alcohol dependence in China measure 2.2% and 3.7%, respectively, approaching those of the Netherlands, United States and other western countries.