Miracle-dz/UniFAR-FTUs huggingface dataset:
Integrated Bioinformatics Analysis of the Clinical Value and Biological Function of ATAD2 in Hepatocellular Carcinoma

ATPase family AAA domain-containing protein 2 (ATAD2), a chromatin regulator and an oncogenic transcription cofactor, is frequently overexpressed in many cancers, particularly in hepatocellular carcinoma (HCC). By integrating open-access online mRNA datasets and our institutional tissue data on HCC, the clinical role and functions of ATAD2 were analyzed by bioinformatic algorithms. We systematically examined ATAD2 expression in HCC based on a large sample population, integrating data from our institution and the GEO, Oncomine, and TCGA datasets. Aberrant ATAD2 expression related to pathways was identified by bioinformatic algorithms. The effects of ATAD2 downregulation on the cycle cell were also determined. A pooled analysis from 28 datasets indicated that ATAD2 overexpression was found in HCC (SMD = 8.88, 95% CI: 5.96–11.81, P < 0.001) and was correlated with poor survival. Subgroup analysis of Asian patients with a serum alpha-fetoprotein (AFP) concentration < 200 ng/ml in stage I + II showed that the ATAD2-high group had a more unfavorable overall survival (OS) rate than the ATAD2-low group. The receiver operating characteristic curve indicated that the efficiency of ATAD2 for HCC diagnosis was considerable (area under the curve = 0.89, 95% CI: 0.86–0.91). Functional analysis based on bioinformatic algorithms demonstrated that ATAD2 participates in cell division, mitotic nuclear division, DNA replication, repair, and cell cycle processes. ATAD2 knockout in HCC cells downregulated cyclin C and cyclin D1 protein levels and resulted in G1/S phase arrest in vitro. The kinesin family member C1 (KIFC1), shugoshin 1 (SGO1), GINS complex subunit 1 (GINS1), and TPX2 microtubule nucleation factor (TPX2) genes were closely related to ATAD2 upregulation. ATAD2 may interact with TTK protein kinase (TTK) to accelerate HCC carcinogenesis. ATAD2 plays a vital role in HCC carcinogenesis by disturbing the interaction between chromatin proteins and DNA. Targeting ATAD2 represents a promising method for the development of therapeutic treatments for cancer.
CEO Overconfidence, Corporate Governance, and the Demand for Directors and Officers Insurance

Previous work shows directors’ and officers’ (D&O) liability coverage provides insight into a firm’s risk-taking and governance. We develop a theoretical model to show how CEO overconfidence impacts D&O insurance decisions. We find firms with overconfident CEOs have a lower demand for D&O insurance. Using an options-based measure for CEO overconfidence, we test this model and find that firms with overconfident CEOs have a lower demand for D&O insurance. This effect holds when controlling for litigation risk, CEO characteristics, firm characteristics, and corporate governance. This work gives insight on how CEO overconfidence impacts corporate risk through the D&O insurance decision.
Supplemental Information A Smoothened-Evc 2 Complex Transduces the Hedgehog Signal at Primary Cilia

Supplemental data 1) Figure S1, related to Figure 1. Evc2 is a positive regulator of Hh signaling localized at the EvC Zone in primary cilia. 2) Figure S2, related to Figure 2. Evc2 is required for Hh signaling at a step between Smo and PKA. 3) Figure S3, related to Figure 3. Evc2 is required for the accumulation of Gli2, but not Smo at primary cilia. 4) Figure S4, related to Figure 4. The Weyers peptide is a localization signal for the EvC Zone. 5) Figure S5, related to Figure 6. Evc2 and Smo form a complex. 6) Figure S6, related to Figure 7. Hh signaling induces the co-localization of Smo and Evc2 at primary cilia. 7) Figure S7, related to Figure 7. The association of Smo with Evc2 requires primary cilia.
New paediatric contrast test: Hiding Heidi low‐contrast ‘face’ test

Background: The Hiding Heidi low‐contrast ‘face’ test is a new paediatric contrast test to evaluate the ability to detect objects with low contrast. The purpose of the present study was to compare the Hiding Heidi low‐contrast ‘face’ test (HH) with the Pelli−Robson contrast sensitivity test (PR) and the functional acuity contrast test (FACT) in the low‐contrast assessment.
Littoral et intérieur de l'Inde

L'Inde, on le sait, compte parmi les exemples de choix de ce qu'on appelle de nos jours le sous-développement. Le motif n'est pas récent. On le retrouve depuis le XVIIe siècle déjà dans les rapports et mémoires des Européens, employés des compagnies ou autres voyageurs. Tel ce directeur du comptoir hollandais à Surat qui s'indigne de l'inefficacité, de l'insouciance et de la corruption des autorités. Lors d'un incendie sérieux dans la ville aucun des notables ne fait quoique ce soit. D'ailleurs qu'est-ce qu'ils auraient pu faire en l'absence totale du matériel nécessaire? Pourtant Surat n'est pas un bled quelconque, mais une ville riche et importante. Plus grave encore, personne ne s'inquiete de ce que son ports'ensable progressivement à cause des alluvions apportées par la rivière. Non seulement personne ne s'en inquiète, mais on aggrave encore les choses en déchargeant le lest dans la rivière. En fin de compte notre témoin doute fort qu'aucune ville placée sous le régime des Mogols puisse durer pour longtemps). Est-ce le sous-développement pur et simple? Ou est-ce qu'il y a autre chose qui joue?
Isoforms of Yeast Cytochrome c Oxidase Subunit V Affect the Binuclear Reaction Center and Alter the Kinetics of Interaction with the Isoforms of Yeast Cytochrome c(*)

Subunit V, one of the nuclear-coded subunits of yeast cytochrome c oxidase, has two isoforms, Va and Vb. These alter the in vivo intramolecular rates of electron transfer within the holoenzyme (Waterland, R. A., Basu, A., Chance, B., and Poyton, R. O.(1991) J. Biol. Chem. 266, 4180-4186). The isozyme with Vb has a higher turnover rate and a higher intramolecular transfer rate than the isozyme with Va. To determine how these isoforms affect catalysis, we have examined their effects on the binuclear reaction center and on the interaction between cytochrome c oxidase and the two isoforms, iso-1 and iso-2, of yeast cytochrome c. Infrared spectroscopy of carbon monoxide liganded to heme a3 has revealed a single conformer for the binuclear reaction center in the isozyme with Vb but two discrete conformers in the isozyme with Va. The kinetics of interaction for all four pairwise combinations of isozymes with each subunit V isoform and the two cytochrome c isoforms are biphasic, with high and low affinity electron transfer reactions. In general, the isoforms of cytochrome c and subunit V do not alter the K but do affect the TNmax. The TNmax for isozymes carrying Vb are higher at both high and low affinity sites for each cytochrome c isoform. Iso-1-cytochrome c supports a higher TNmax than Iso-2-cytochrome c. Surprisingly, the combinatorial effect of both sets of isoforms on TNmax is minimized with the pairs of isoforms (iso-1-cytochrome c and subunit Va or iso-2 and subunit Vb) that are co-expressed in cells. Together, these findings support the conclusion that the subunit V isoforms modulate catalysis and suggest that they do so by affecting the environment or structure of the binuclear reaction center. They also suggest that the co-expression of the two cytochrome c isoforms with two subunit V isoforms serves to minimize differences in electron transfer rates brought about by the subunit V isoforms.
The present global financial and economic crisis poses an additional risk factor for mental health problems on the employees.

BACKGROUND The global financial and economic crisis starting in 2007 led to a deterioration of several socio-economic determinants of mental health. The aim of this cross-sectional study was to examine the impact of the present economic crisis on the depression and anxiety levels of the employed in the private and public sector in Slovenia. SUBJECTS AND METHODS Altogether 1592 employees completed an internet based self-reported questionnaire. Data about perceived impact of the economic crisis, several socio-demographic, socioeconomic, and health parameters were collected. Depression symptoms were assessed by the Center for Epidemiological Studies-Depression Scale and anxiety symptoms by the Spielberger State-Inventory. Regression models were used 1) to explore the associations of the economic crisis with the level of depression and anxiety symptoms while controlling for some sociodemographic and work characteristic variables, and 2) to understand the relationship between some potentially important socioeconomic variables and the perception of the economic crisis. RESULTS Depressive and anxiety scores were significantly increased among 590 (46.6%) employees being affected by the economic crisis. The level of depressive symptoms was significantly associated with perceived impact by the crisis, recent sick leave, reported injuries sustained at work, benzodiazepine and analgesic use, the lack of emotional support, and trust in crisis telephone lines. The level of anxiety symptoms yielded the robust association with the level of depression symptoms, reported injuries sustained on the way to work and education. CONCLUSIONS The economic crisis poses an additional risk factor for mental health problems which clinicians should internalize and become more aware of them. Symptoms of depression and anxiety can be masked in high-utilizers of medical care with physical complaints or psychoactive drug use.
Effect of graduated elastic compression stockings on leg symptoms and signs during exercise in patients with deep venous thrombosis: a randomized cross‐over trial 1

Summary. Graduated elastic compression stockings (ECS) are often prescribed after deep venous thrombosis (DVT) to alleviate acute symptoms and to prevent and treat post‐thrombotic syndrome (PTS). In patients with DVT, leg symptoms tend to worsen with exercise. The effects of ECS use during exercise have not been studied. Objectives were to determine whether ECS improve symptoms and signs and increase exercise capacity when worn during treadmill exercise by patients with prior DVT, with or without PTS. The methods employed a randomized cross‐over trial. We recruited subjects who had a first episode of unilateral DVT at least 1 year earlier and categorized them as having, or not having, the PTS using a validated scale. Subjects underwent two identical treadmill exercise sessions at least 1 week apart, and were randomly assigned to wear knee‐length 30 mmHg ECS on the affected leg during one of the two sessions. Venous symptoms, leg volume, leg circumference and calf muscle flexibility were measured in the affected leg before and after both exercise sessions. Subjects achieved similar percentage maximum predicted heart rates during both sessions. Comparing the ECS to no ECS session, there were no significant differences in treadmill time (21.2 vs. 21.2 min, P = 0.94), gain in leg volume (71 vs. 73 mL, P = 0.83), or change in soleus or gastrocnemius flexibility, whether or not PTS was present. Symptoms in general worsened slightly with exercise regardless of whether or not ECS were worn and did not differ according to PTS status. Per‐subject analysis showed that use of ECS resulted in global improvement of symptoms in 25% of subjects, global worsening in 33% of subjects, and had no or inconsistent effects in 42% of subjects. Whether or not PTS was present, the use of ECS during exercise by patients with prior DVT did not improve symptoms and signs during exercise or increase exercise capacity.
The Victorians and the Visual Imagination

1. The visible and the unseen 2. 'The mote within the eye' 3. Blindness and insight 4. Lifting the veil 5. Under the ice 6. The buried city 7. The role of the art critic 8. Criticism, language and narrative 9. Surface and depth 10. Hallucination and vision Conclusion: the Victorian horizon.
The influence of meteoric smoke particle attributions on polar mesospheric clouds formation

It is known that the formation of polar mesospheric clouds (PMCs) is correlated with temperature, concentration and desublimation nuclei of water vapor. The primary candidate of these nuclei is believed to be meteoric smoke particles. In this study, we have surveyed the influence of meteoric smoke particle attributions on polar mesospheric ice clouds formation. It is found that the large smoke particles with radium of 2-3 nm will dominate the nucleation of water vapor.
Automated real-time video surveillance algorithms for SoC implementation: A survey

Numerous techniques and algorithms have been developed and implemented, primarily in software, for object tracking, detection and recognition. A few attempts have been made to implement some of the algorithms in hardware. However, those attempts have not yielded optimal results in terms of accuracy, power and memory requirements. The aim of this paper is to explore and investigate a number of possible algorithms for real-time video surveillance, revealing their various theories, relationships, shortcomings, advantages and disadvantages, and pointing out their unsolved problems of practical interest in principled way, which would be of tremendous value to engineers and researchers trying to decide what algorithm among those many in literature is most suitable to specific application and the particular real-time System-on-Chip (SoC) implementation.
Correlations between climate network and relief data

Abstract. In the last few years, the scientific community has witnessed an ongoing trend of using ideas developed in the study of complex networks to analyze climate dynamics. This powerful combination, usually called climate networks, can be used to uncover non-trivial patterns of weather changes throughout the years. Here we investigate the temperature network of the North American region and show that two network characteristics, namely degree and clustering, have marked differences between the eastern and western regions. We show that such differences are a reflection of the presence of a large network community on the western side of the continent. Moreover, we provide evidence that this large community is a consequence of the peculiar characteristics of the western relief of North America.
A noninverting genome of a viable herpes simplex virus 1: presence of head-to-tail linkages in packaged genomes and requirements for circularization after infection

The wild-type herpes simplex virus 1 genome consists of two components, L and S, which invert relative to each other, giving rise to four isomers. Previously we reported the construction of a herpes simplex virus 1 genome, HSV-1(F)I358, from which 15 kilobase pairs of DNA spanning the junction between L and S components were deleted and which no longer inverted (Poffenberger et al., Proc. Natl. Acad. Sci. U.S.A. 80:2690-2694, 1983). Further studies on the structure of HSV-1(F)I358 revealed the presence of two submolar populations among packaged DNA. The first, comprising no more than 10% of total packaged DNA, consisted of defective genomes with a subunit size of 36 kilobase pairs. The results suggest that this population arose by recombination through a directly repeated sequence inserted in place of the deleted L-S junction. The second minor population consisted of HSV-1(F)I358 DNA linked head-to-tail. Analyses of the structure of HSV-1(F)I358 DNA after infection indicated that the fraction of total DNA linked head-to-tail increased to approximately 40 to 50% within 30 min after exposure of cells to virus. The formation of head-to-tail linkages did not require de novo protein synthesis. Our interpretation of the results is that the termini of full-length DNA molecules are held together during packaging, that a small fraction of the termini is covalently linked during or after packaging, and that the remainder is covalently joined after the release of viral DNA from the infecting virus by either host or viral factors introduced into the cell during infection.
Evaluation of Water Quality Pollution Indices for Heavy Metal Contamination Monitoring in the Water of Harike Wetland ( Ramsar Site ) , India

The diverse functions of wetlands are being adversely affected by human activities. Harike wetland has high ecological significance as it provides home to diverse flora and fauna, habitat for feeding and breeding and social interactions. This paper discusses an integrated approach of pollution indices and statistical techniques to assess the intensity of heavy metal pollution discharged from various industries in Harike wetland. This wetland is highly polluted due to the rapid industrialization, urbanization and dumping of solid wastes. The water quality of the wetland has been studied with reference to various toxic metals. The metals analyzed include lead, chromium, iron, copper, nickel, zinc and cadmium. The quality of water has drastically deteriorated due to the mixing of the heavy metals. Most of the metal ions were in higher concentration compared to the international standards. It has been observed that the quality of water is not safe for various aquatic and even unfit for human drinking and irrigation purposes, therefore, necessary conservation and management measures should be taken to improve the deteriorating water quality of this globally recognized wetland.
A New Model for Integrating Phases of Decision-Making and Knowledge Base for Improving Customer Satisfaction

Knowledge base is becoming a key factor within organisations, since it can maximise the probability and impact of customer satisfaction in, for example, an airline company. Therefore, phases of decision-making and knowledge base are widely used in airline companies to improve the degree of customer satisfaction. The objective of this paper is to develop a customer satisfaction model by integrating the phases of decision-making and knowledge base of Royal Jordanian Airlines. The data collection for this study is achieved quantitatively through a survey based on a sample set of 130. All individuals in the sample are employed by Royal Jordanian Airlines and are targeted with questionnaires, while the smart partial least squares (PLSs) technique is employed to analytically test each hypothesis. The results of the study find a positive interaction between the decision-making phases of intelligence and design in enhancing customer satisfaction, which is fully mediated by knowledge base. In addition, the results find a positive interaction between the decision-making phases of choice and implementation in enhancing customer satisfaction, which is partially mediated by knowledge base.
Call to interact: communicating interactivity and affordances for contactless gesture controlled public displays

Interactive public displays are becoming increasingly commonplace. Two important challenges for these displays exist: 1) how interactivity is communicated to the passer-by and 2) once the audience have engaged, how the interactive affordances are communicated. We explore these challenges through the lens of a new emerging interaction modality - contactless mid-air gesture controlled public displays. This paper presents several solutions to the problems above, inspired by the findings existing within the related research on public displays. These solutions are deployed in an in-the-wild setting - a cinema for an 8 week duration - and evaluated through observational and quantitative research. The data forms a set of design guidelines for successfully attracting the passer-by and conveying the affordances of the contactless gestural public displays.
Learning to Assemble Objects with a Robot Swarm (Extended Abstract)

Gregor H.W. Gebhardt Computational Learning for Autonomous Systems, Technische Universität Darmstadt Kevin Daun Computational Learning for Autonomous Systems, Technische Universität Darmstadt Marius Schnaubelt Computational Learning for Autonomous Systems, Technische Universität Darmstadt Alexander Hendrich Computational Learning for Autonomous Systems, Technische Universität Darmstadt Daniel Kauth Computational Learning for Autonomous Systems, Technische Universität Darmstadt Gerhard Neumann Lincoln Centre for Autonomous Systems, School of Computer Science, University of Lincoln
Eyes draw auxiliary lines before insight moment

The human eyes are a powerful sensor to detect valuable objects, and of the valuable structure among objects in the environment. Scientists executed experiments on these balls, for investigating the attention of human in searching things to buy and in exploring clues for problem solving. The shift of attention target toward insight has been reported in previous studies, but it has not been clarified how logical ideas of human is emerging for the short time attaining insight. This paper reports the discovery that the orbits of eyes' target movement just before insight can be regarded as auxiliary lines, i.e., lines which externalize the hidden relationship of objects which accelerate the human's deeper thought. The experiments were executed for subjects looking at artificial products and artworks and also for subjects designing a new city on a map. The snapshots of eye movements can be interpreted as reflecting the subjects' interest in combining basic parts to make a valuable structure. By showing the snapshot just before insight to subjects themselves, they tended to notice why they attained insight and could explain the value of the objects to others.
The Dynamical Perspective in Personality and Social Psychology

Human experience reflects the interplay of multiple forces operating on various time scales to promote constantly evolving patterns of thought, emotion, and action. The complexity and dynamism of personal and social phenomena have long been recognized, but capturing these features of psychological process represents a serious challenge for traditional research methods. In this article, we introduce basic concepts and methods from the study of nonlinear dynamical systems, and we outline the relevance of these ideas and approaches for investigating phenomena at different levels of psychological reality. We suggest that the dynamical perspective is ideally suited to capture the emergence and maintenance of global properties in a psychological system, and for investigating the time-dependent relation between external influences and a system's internally generated forces. Although fairly new to personality and social psychology, the dynamical perspective has been implemented with respect to a wide variety of phenomena, utilizing both empirical methods and computer simulations. This diversity of topics and methods is reflected in the articles comprising the special issue.
Therapeutic efficacy of intravenously administered transferrin-conjugated dendriplexes on prostate carcinomas.

AIM Improved treatments for prostate cancer are critically needed in order to overcome metastasis and lethal recurrence. Intravenously administered gene therapy would be an attractive anticancer treatment strategy; however, the lack of suitable carrier systems able to selectively deliver therapeutic genes to tumors has so far limited this investigation. Given that transferrin receptors are overexpressed on prostate cancer cells, the purpose of this study is to determine whether transferrin-conjugated dendriplexes encoding TNF-α, TNF-related apoptosis-inducing ligand and IL-12 would suppress the growth of prostate cancer cell lines in vitro and in vivo. MATERIALS & METHODS Transferrin-conjugated dendriplexes encoding TNF-α, TNF-related apoptosis-inducing ligand and IL-12 were intravenously administered to mice bearing subcutaneous PC-3 and DU145 tumors. RESULTS The administration of the transferrin-conjugated generation 3 diaminobutyric polypropylenimine dendriplex encoding TNF-a resulted in tumor suppression for 60% of PC-3 and 50% of DU145 prostate tumors. CONCLUSION These dendriplexes hold great potential as a novel approach for prostate cancer therapy.