Miracle-dz/UniFAR-FTUs huggingface dataset:
Teaching staff's views about the internationalisation of higher education: the case of two bilingual communities in Spain

The process of internationalisation of higher education can be seen as fluctuating between two main discourses: economic competition and academic internationalisation (Bolsman & Miller 2008). Within the former type of discourse, internationalisation is constructed as a means to generate income, in competition with other institutions, through the provision of research and teaching services of a high quality to as many ‘clients’ as possible. From the point of view of academic internationalism, internationalisation is represented as a joint enterprise by institutions from different countries for the advancement of human knowledge and intercultural understanding. In this paper we aim to explore the views of the teaching staff of two bilingual universities in Spain in connection with the process of internationalisation of their institution, placing a special emphasis on its impact on language policy. The sample for this study was made up of 173 university teaching staff who completed a questionnaire in which they were asked to express their views on issues such as internationalisation at higher education institutions, academic mobility and their attitudes towards multilingualism. The participants belonged to two officially bilingual universities in Spain, namely the University of Lleida (UdL) and the University of the Basque Country (UBC). Variables such as the sociolinguistic context, gender, mother tongue and age were considered when scrutinising the participants’ answers with a view to drawing a picture of internationalisation which included opinions on academic mobility and multilingualism from the teaching staff’s perspective.
Procalcitonin as a Biomarker for Predicting Amputation Level in Lower Extremity Infections

ABSTRACT Inflammatory markers are essential tools in the decision‐making process for lower extremity infections. When coupled with objective findings, clinicians can more accurately diagnose and treat these entities. Typically, markers such as the white blood cell count, erythrocyte sedimentation rate, and C‐reactive protein are used to initially assess these patients or monitor the progression of medical or surgical therapy. Procalcitonin is a newer inflammatory marker that is specific for an infectious process. Originally, procalcitonin was used to monitor antibiotic therapy and sepsis for patients in the intensive care setting, but it has now been expanded to other facets of medicine. The utility of procalcitonin has been described for diagnosing infection or osteomyelitis in diabetic foot ulcers. However, limited research has compared inflammatory marker levels and the level of amputation. A retrospective inpatient medical record review was performed of 156 consecutive patient occurrences during 25 months in which surgical intervention was required for a lower extremity infection and an initial procalcitonin level had been obtained. This initial procalcitonin value was then compared with the level of amputation at the final surgical intervention. A highly statistically significant difference was found when comparing those who underwent a below‐the‐knee or above‐the‐knee amputation (median procalcitonin 1.72 ng/mL) and those who did not (median procalcitonin 0.105 ng/mL; p < .001). Therefore, patients with higher initial procalcitonin values were more likely to undergo below‐the‐knee or above‐the‐knee amputation or require aggressive surgical intervention. Thus, the procalcitonin level can provide valuable initial information to the clinician.
Cosmological parameter determination in free-form strong gravitational lens modelling

We develop a novel statistical strong lensing approach to probe the cosmological parameters by exploiting multiple redshift image systems behind galaxies or galaxy clusters. The method relies on free-form mass inversion of strong lenses and does not need any additional information other than gravitational lensing. Since in free-form lensing the solution space is a high-dimensional convex polytope, we consider Bayesian model comparison analysis to infer the cosmological parameters. The volume of the solution space is taken as a tracer of the probability of the underlying cosmological assumption. In contrast to parametric mass inversions, our method accounts for the mass-sheet degeneracy, which implies a degeneracy between the steepness of the profile and the cosmological parameters. Parametric models typically break this degeneracy, introducing hidden priors to the analysis that contaminate the inference of the parameters. We test our method with synthetic lenses, showing that it is able to infer the assumed cosmological parameters. Applied to the CLASH clusters, the method might be competitive with other probes.
Leptospirosis and Depression: A Nationwide Cohort Analysis.

OBJECTIVE We conducted a retrospective cohort study to investigate whether leptospirosis is a risk factor for depression. METHOD From the Taiwan National Health Insurance Research Database between 2000 and 2010, patients with leptospirosis (ICD-9 code 100) who did not have a history of depression (ICD-9-CM codes 296.2, 296.3, 300.4, and 311) before the index date were enrolled (leptospirosis cohort). For each patient with leptospirosis, 1 control without a history of leptospirosis and depression was randomly selected (nonleptospirosis cohort). Cox proportional hazards regression models were used to analyze the risk of depression according to sex, age, and comorbidities. RESULTS In the leptospirosis and nonleptospirosis cohorts, we observed 34 patients with depression, with the incidence rate of 2.87 per 1,000 person-years, and 25 patients with depression, with the incidence rate of 1.93 per 1,000 person-years, respectively, yielding a crude hazard ratio (HR) of 1.49 (95% confidence interval [CI], 1.25-1.77) and an adjusted HR (aHR) of 1.58 (95% CI, 1.34-1.88). Compared with the nonleptospirosis cohort, the leptospirosis cohort had a risk of depression stratified by sex, age, and comorbidity that was higher in female patients (aHR = 2.08; 95% CI, 1.54-2.80), patients younger than 49 years old (aHR = 3.19; 95% CI, 2.39-4.27), and patients without comorbidity (aHR = 2.14; 95% CI, 1.68-2.71). The risk of depression was higher in women than in men (aHR = 1.90; 95% CI, 1.61-2.25) and in patients with comorbidities, namely hyperlipidemia (aHR = 1.80; 95% CI, 1.40-2.31), coronary artery disease (aHR = 2.47; 95% CI, 1.96-3.12), stroke (aHR = 1.77; 95% CI, 1.39-2.24), and septicemia (aHR = 2.06; 95% CI, 1.64-2.58). CONCLUSIONS Patients with leptospirosis have a 1.58-fold higher risk of depression than that in the general population. Physicians should be alert to the emotional condition and depression symptoms of people who had been suffering from leptospirosis.
Estimation of long range correlations and FARIMA modelling of wind speed in Maharashtra

Modelling and forecasting of solar insolation and wind speed are extremely important in the design and operation of decentralized power generation systems like microgrids. For Indian conditions with varied geographic features, wind speed temporal dynamics are highly characterized by intermittency, due to weather and climatic changes. Modelling of wind speed is done for accurate prediction under different time regimes. Time series models are the most commonly used, for modelling and forecasting due to its simplicity. They easily capture the statistical properties of the data, with medium term forecasting of hours to day ahead with reasonable accuracy. Models such as ARMA and ARIMA have already been used for midterm forecasting for wind speed, and solar insolation data. Analysis of long term temporal and spatial variability of wind speed data is useful for modelling wind related phenomena and quantification of long term wind potential in a location. Detrended Fluctuation Analysis (DFA) is a method to quantify long range correlations in non-stationary time series. This paper describes a Fractional Autoregressive Moving Average (FARIMA) Model applied to a non-stationary wind speed data for a year at a location in Maharashtra. This model combines conventional modelling technique with long term temporal characteristics of the data. Model results provide information related to autocorrelation properties of the given data. The midterm forecasting results are compared with conventional persistence, ARMA and ARIMA Models to highlight the application suitability.
Association of the Lung Immune Prognostic Index With Immune Checkpoint Inhibitor Outcomes in Patients With Advanced Non–Small Cell Lung Cancer

Importance Derived neutrophils/(leukocytes minus neutrophils) ratio (dNLR) and lactate dehydrogenase (LDH) level have been correlated with immune checkpoint inhibitor (ICI) outcomes in patients with melanoma. Objective To determine whether pretreatment dNLR and LDH are associated with resistance to ICIs in patients with advanced non–small cell lung cancer (NSCLC). Design, Setting, and Participants Multicenter retrospective study with a test (n = 161) and a validation set (n = 305) treated with programmed death 1/programmed death ligand 1 (PD-1/PD-L1) inhibitors in 8 European centers, and a control cohort (n = 162) treated with chemotherapy only. Complete blood cell counts, LDH, and albumin levels were measured before ICI treatment. A lung immune prognostic index (LIPI) based on dNLR greater than 3 and LDH greater than upper limit of normal (ULN) was developed, characterizing 3 groups (good, 0 factors; intermediate, 1 factor; poor, 2 factors). Main Outcomes and Measures The primary end point was overall survival (OS). Secondary end points were progression-free survival (PFS) and disease control rate (DCR). Results In the pooled ICI cohort (N = 466), 301 patients (65%) were male, 422 (90%) were current or former smokers, and 401 (87%) had performance status of 1 or less; median age at diagnosis was 62 (range, 29-86) years; 270 (58%) had adenocarcinoma and 159 (34%) had squamous histologic subtype. Among 129 patients with PD-L1 data, 96 (74%) had PD-L1 of at least 1% by immunohistochemical analysis, and 33 (26%) had negative results. In the test cohort, median PFS and OS were 3 (95% CI, 2-4) and 10 (95% CI, 8-13) months, respectively. A dNLR greater than 3 and LDH greater than ULN were independently associated with OS (hazard ratio [HR] 2.22; 95% CI, 1.23-4.01 and HR, 2.51; 95% CI, 1.32-4.76, respectively). Median OS for poor, intermediate, and good LIPI was 3 months (95% CI, 1 month to not reached [NR]), 10 months (95% CI, 8 months to NR), and 34 months (95% CI, 17 months to NR), respectively, and median PFS was 2.0 (95% CI, 1.7-4.0), 3.7 (95% CI, 3.0-4.8), and 6.3 (95% CI, 5.0-8.0) months (both P < .001). Disease control rate was also correlated with dNLR greater than 3 and LDH greater than ULN. Results were reproducible in the ICI validation cohort for OS, PFS, and DCR, but were nonsignificant in the chemotherapy cohort. Conclusions and Relevance Pretreatment LIPI, combining dNLR greater than 3 and LDH greater than ULN, was correlated with worse outcomes for ICI, but not for chemotherapy, suggesting that LIPI can serve as a potentially useful tool when selecting ICI treatment, raising the hypothesis that the LIPI might be useful for identifying patients unlikely to benefit from treatment with an ICI.
Subliminal and supraliminal processing of reward-related stimuli in anorexia nervosa

Background Previous studies have highlighted the role of the brain reward and cognitive control systems in the etiology of anorexia nervosa (AN). In an attempt to disentangle the relative contribution of these systems to the disorder, we used functional magnetic resonance imaging (fMRI) to investigate hemodynamic responses to reward-related stimuli presented both subliminally and supraliminally in acutely underweight AN patients and age-matched healthy controls (HC). Methods fMRI data were collected from a total of 35 AN patients and 35 HC, while they passively viewed subliminally and supraliminally presented streams of food, positive social, and neutral stimuli. Activation patterns of the group × stimulation condition × stimulus type interaction were interrogated to investigate potential group differences in processing different stimulus types under the two stimulation conditions. Moreover, changes in functional connectivity were investigated using generalized psychophysiological interaction analysis. Results AN patients showed a generally increased response to supraliminally presented stimuli in the inferior frontal junction (IFJ), but no alterations within the reward system. Increased activation during supraliminal stimulation with food stimuli was observed in the AN group in visual regions including superior occipital gyrus and the fusiform gyrus/parahippocampal gyrus. No group difference was found with respect to the subliminal stimulation condition and functional connectivity. Conclusion Increased IFJ activation in AN during supraliminal stimulation may indicate hyperactive cognitive control, which resonates with clinical presentation of excessive self-control in AN patients. Increased activation to food stimuli in visual regions may be interpreted in light of an attentional food bias in AN.
Gingival melanin depigmentation by Er:YAG laser: A literature review

ABSTRACT Laser ablation is recently suggested as a most effective and reliable technique for depigmentation of melanin hyperpigmented gingiva. To date, different lasers have been used for gingival depigmentation (CO2, diode, Nd:YAG, Er:YAG and Er,Cr:YSGG lasers). The use of Er:YAG laser for depigmentation of melanin hyperpigmented gingiva has gained increasing importance in recent years. The purpose of this study was to report removal of gingival melanin pigmentation using an Er:YAG laser in a literature review. The main outcomes, such as improvement of signs (clinical parameters of bleeding, erythema, swelling and wound healing), symptoms (pain) and melanin recurrence/repigmentation were measured. The literature demonstrated that depigmentation of gingival melanin pigmentation can be performed safely and effectively by Er:YAG laser resulting in healing and an esthetically significant improvement of gingival discoloration. Thus, Er:YAG laser seems to be safe and useful in melanin depigmentation procedure. However, the main issue in giving the final conclusion of the optimal Er:YAG laser use in melanin depigmentation is that, to date, studies are offering completely discrepant Er:YAG laser procedure protocols (complex settings of laser parameters), and different criteria for the assessment of depigmentation and repigmentation (recurrence), thus hampering the comparison of the results. Therefore, further studies are necessary to give an optimal recommendation on the use of Er:YAG laser in gingival melanin hyperpigmentation.
Benchmark analysis of algorithms for determining and quantifying full-length mRNA splice forms from RNA-seq data

The advantages of RNA sequencing (RNA-Seq) suggest it will replace microarrays for highly parallel gene expression analysis. For example, in contrast to arrays, RNA-Seq is expected to be able to provide accurate identification and quantification of full-length transcripts. A number of methods have been developed for this purpose, but short error prone reads makes it a difficult problem in practice. It is essential to determine which algorithms perform best, and where and why they fail. However, there is a dearth of independent and unbiased benchmarking studies of these algorithms. Here we take an approach using both simulated and experimental benchmark data to evaluate their accuracy. We conclude that most methods are inaccurate even using idealized data, and that no is method sufficiently accurate once complicating factors such as polymorphisms, intron signal, sequencing error, and multiple splice forms are present. These results point to the pressing need for further algorithm development.
Precise executable interprocedural slices

The notion of a <italic>program slice</italic>, originally introduced by Mark Weiser, is useful in program debugging, automatic parallelization, program integration, and software maintenance. A slice of a program is taken with respect to a program point <italic>p</italic> and a variable <italic>x</italic>; the slice consists of all statements of the program that might affect the value of <italic>x</italic> at point <italic>p</italic>. An interprocedural slice is a slice of an entire program, where the slice crosses the boundaries of procedure calls. Weiser's original interprocedural-slicing algorithm produces imprecise slices that are executable programs. A recent algorithm developed by Horwitz, Reps, and Binkley produces more precise (smaller) slices by more accurately identifying those statements that might affect the values of <italic>x</italic> at point <italic>p</italic>. These slices, however, are not executable. An extension to their algorithm that produces more precise executable interprocedural slices is described together with a proof of correctness for the new algorithm.
Purpose in Life Among Centenarian Offspring.

Objectives Purpose in life (PIL), a feeling of meaning and direction in life, is associated with favorable health outcomes including lower mortality and reduced risk of disease, disability, and cognitive impairment. Since centenarian offspring have been shown to have long health spans we sought to examine whether they have higher PIL than individuals without familial longevity. Method We compared PIL scores from the Ryff Scales of Psychological Well-Being in centenarian offspring from the New England Centenarian Study (N=361, mean age=82.0 years) with three referent groups: spouses, birth cohort-matched referents, and Health and Retirement Study (HRS) participants. Results Logistic regression analyses adjusted for age, sex, education, and marital status indicated greater odds of high PIL among centenarian offspring compared with spouse (adjusted odds ratio [aOR] 1.92, 95% CI 1.002-3.68, p=.049) and birth cohort referents (aOR 2.64, 95% CI 1.36-5.14, p=.004). Offspring had an almost three times greater odds of having high PIL than HRS participants (OR 2.93, 95% CI 2.17-3.96, p<0.0001). Discussion Higher PIL is associated with being an offspring of a long-lived parent and may play a role in the ability to delay age-associated illnesses and functional decline. Increasing purposefulness may be a target for interventions to promote healthy aging.
A Phase II study of palonosetron, aprepitant, dexamethasone and olanzapine for the prevention of cisplatin-based chemotherapy-induced nausea and vomiting in patients with thoracic malignancy

Background The three-drug combination of a 5-hydroxytryptamine type 3 receptor antagonist, a neurokinin 1 receptor antagonist and dexamethasone is recommended for patients receiving highly emetogenic chemotherapy. However, standard antiemetic therapy is not completely effective in all patients. Methods We conducted an open-label, single-center, single-arm Phase II study to evaluate the efficacy of olanzapine in combination with standard antiemetic therapy in preventing chemotherapy-induced nausea and vomiting in patients with thoracic malignancy receiving their first cycle of cisplatin-based chemotherapy. Patients received 5 mg oral olanzapine on Days 1-5 in combination with standard antiemetic therapy. The primary endpoint was complete response (no vomiting and no use of rescue therapy) during the overall Phase (0-120 h post-chemotherapy). Results Twenty-three men and seven women were enrolled between May and October 2015. The median age was 64 years (range: 36-75 years). The most common chemotherapy regimen was 75 mg/m2 cisplatin and 500 mg/m2 pemetrexed, which was administered to 14 patients. Complete response rates in acute (0-24 h post-chemotherapy), delayed (24-120 h post-chemotherapy) and overall phases were 100%, 83% and 83% (90% confidence interval: 70-92%; 95% confidence interval: 66-93%), respectively. There were no Grade 3 or Grade 4 adverse events. Although four patients (13%) experienced Grade 1 somnolence, no patients discontinued olanzapine. Conclusions The addition of 5 mg oral olanzapine to standard antiemetic therapy demonstrates promising efficacy in preventing cisplatin-based chemotherapy-induced nausea and vomiting and an acceptable safety profile in patients with thoracic malignancy.
Leverage Website Favicon to Detect Phishing Websites

Phishing attack is a cybercrime that can lead to severe financial losses for Internet users and entrepreneurs. Typically, phishers are fond of using fuzzy techniques during the creation of a website. They confuse the victim by imitating the appearance and content of a legitimate website. In addition, many websites are vulnerable to phishing attacks, including financial institutions, social networks, e-commerce, and airline websites. This paper is an extension of our previous work that leverages the favicon with Google image search to reveal the identity of a website. Our identity retrieval technique involves an effective mathematical model that can be used to assist in retrieving the right identity from the many entries of the search results. In this paper, we introduced an enhanced version of the favicon-based phishing attack detection with the introduction of the Domain Name Amplification feature and incorporation of addition features. Additional features are very useful when the website being examined does not have a favicon. We have collected a total of 5,000 phishing websites from PhishTank and 5,000 legitimate websites from Alexa to verify the effectiveness of the proposed method. From the experimental results, we achieved a 96.93% true positive rate with only a 4.13% false positive rate.
Observation as the initial management strategy in patients with mantle cell lymphoma

Background Patients with mantle cell lymphoma (MCL) follow a heterogeneous clinical course. While they generally require treatment initiation shortly after diagnosis, it is unclear whether deferring treatment in selected patients with an indolent clinical behavior affects their overall outcome. Patients and methods In this population-based study, all patients diagnosed with MCL during 1998-2014 were identified in the British Columbia Cancer Agency Lymphoid Cancer Database. The associations between clinico-pathologic characteristics, including the expression of Ki67, SOX11, and TP53, and time to treatment (TtT) and OS were analyzed. Results A total of 440 patients with MCL were evaluated: 365 (83%) received early treatment and 75 (17%) were observed ≥3 months. In the observation group, 54 (72%) patients had a nodal presentation, 16 (21%) a non-nodal presentation, and 5 (7%) had only gastrointestinal involvement. Characteristics associated with deferred treatment included good performance status, no B symptoms, low LDH, non-bulky disease, non-blastoid morphology, and lower Ki67 values. The median TtT in the observation group was 35 months (range 5-79), and 60 (80%) patients were observed beyond 12 months. The median OS was significantly longer in the observation group than in the early treatment group (72 versus 52.5 months, respectively, P = 0.041). In multivariable analysis, treatment decision was not associated with OS [HR 0.804 (95% CI 0.529-1.221), P = 0.306]. Conclusions A subgroup of patients with MCL may be safely observed from diagnosis without negatively impacting their outcomes, including patients with non-nodal presentation as well as asymptomatic patients with low burden nodal presentation and a low proliferative rate.