Miracle-dz/UniFAR-FTUs huggingface dataset:
Challenges for Static Analysis of Java Reflection - Literature Review and Empirical Study

The behavior of software that uses the Java Reflection API is fundamentally hard to predict by analyzing code. Only recent static analysis approaches can resolve reflection under unsound yet pragmatic assumptions. We survey what approaches exist and what their limitations are. We then analyze how real-world Java code uses the Reflection API, and how many Java projects contain code challenging state-of-the-art static analysis. Using a systematic literature review we collected and categorized all known methods of statically approximating reflective Java code. Next to this we constructed a representative corpus of Java systems and collected descriptive statistics of the usage of the Reflection API. We then applied an analysis on the abstract syntax trees of all source code to count code idioms which go beyond the limitation boundaries of static analysis approaches. The resulting data answers the research questions. The corpus, the tool and the results are openly available. We conclude that the need for unsound assumptions to resolve reflection is widely supported. In our corpus, reflection can not be ignored for 78% of the projects. Common challenges for analysis tools such as non-exceptional exceptions, programmatic filtering meta objects, semantics of collections, and dynamic proxies, widely occur in the corpus. For Java software engineers prioritizing on robustness, we list tactics to obtain more easy to analyze reflection code, and for static analysis tool builders we provide a list of opportunities to have significant impact on real Java code.
N′-(5-Chloro-2-hydroxybenzylidene)-4-methoxybenzohydrazide

The asymmetric unit of the title compound, C(15)H(13)ClN(2)O(3), contains two independent hydrazone mol-ecules. Each mol-ecule adopts an E configuration with respect to the methyl-idene unit and forms an intra-molecular O-H⋯N hydrogen bond. The principal difference between the two unique mol-ecules is the relative orientation of the two benzene rings, the dihedral angles between them being 4.0 (3) and 65.9 (3)°, respectively. In the crystal, mol-ecules are linked through N-H⋯O hydrogen bonds, forming chains running along the c axis.
Urinary‐Free Cortisol Excretion in Relation to Age in Acutely Stressed Persons with Depressive Symptoms

&NA; We examined the relationship between age and urinary excretion of free cortisol in acutely stressed middle‐aged and elderly persons. We observed that elderly persons under stress excreted larger amounts of urinary‐free cortisol than did middle‐aged persons; Pearson's r between age and cortisol = 0.38, p less than 0.05. When the sample was stratified by severity of depressive symptoms, the relationship between age and cortisol excretion was strongly accentuated among those with severe depressive symptoms (r = 0.62, p = 0.01) and diminished among those with milder symptoms (r = 0.25, N.S.). Potentially confounding factors such as diet, use of medications, and physical stature were controlled and did not explain the observations. The high depression scores in this acutely stressed sample were indicative of a higher severity of stress response and also a higher risk of occurrence of depressive syndromes. The depressive syndromes did not resemble depressive disorder of an endogenous nature.
Autocalibration Algorithm for Robust Capon Beamforming

The robust Capon beamformer (RCB) is more robust than the standard Capon beamformer when there is uncertainty, as in the case of a sensor location error or an array model mismatch. However, the RCB suffers from mutual coupling between the array sensors, which is difficult to neglect in practice. In this work, an autocalibration algorithm is described that improves the RCB by recursively calibrating the uncertainty due to mutual coupling. The proposed method is better able to estimate the angle-of-arrival and power of the signal of interest than the RCB, as shown by numerical simulation and practical analysis of experimental data obtained in an anechoic chamber
Effect of tetracycline on the phagocytic function of human leukocytes.

Phagocytosis and the intracellular killing of microbes are fundamental functions of polymorphonuclear neutrophil leukocytes. Bacteriostatic antibiotics are effective only with proper neutrophil function. Thus, inhibition of leukocyte function by bacteriostatic antibiotics may have important therapeutic implications. The possibility that these functions of peripheral blood leukocytes may be effected during antimicrobial therapy has not been investigated extensively. The purpose of the present study was to extend earlier investigations into the effect of tetracycline on phagocytosis of bacteria and yeast by human neutrophils. Reports on the effect of tetracycline on the function of leukocytes have been contradictory. In 1950 an engulfment-inhibiting effect was ascribed to chloratetracycline [1]. However, in a later report by other investigators, no such effect was demonstrated with tetracycline hydrochloride [2]. In more recent reports tetracycline hydrochloride has been shown to inhibit chemotaxis [3, 4] and maximal reduction of nitroblue tetrazolium dye (NBT) [5] by human leukocytes. In one study tetracyclines were shown to inhibit the bactericidal effect of serum, but not opsonization of bacteria [6].
Draft Genome Sequence of Lichen-Forming Fungus Cladonia metacorallifera Strain KoLRI002260

ABSTRACT The lichen-forming fungus Cladonia metacorallifera strain KoLRI002260 is capable of producing a number of secondary metabolites, including usnic, didymic, and squamatic acids, which have antitumor, antioxidant, and antibiotic activities. The draft genome assembly has a size of 36,682,060 bp, with a G+C content of 44.91%, and consists of 30 scaffolds.
Isolation and expression of cDNA clones encoding mammalian poly(A) polymerase.

cDNA clones encoding mammalian poly(A) polymerase were isolated with probes generated by the polymerase chain reaction based on amino acid sequences derived from the purified enzyme. A bovine cDNA clone was obtained encoding a protein of 82 kDa. Expression in Escherichia coli resulted in the appearance of a poly(A) polymerase activity that was dependent on the addition of the purified specificity factor CPF and the presence of the polyadenylation signal AAUAAA in the RNA substrate. The activity copurified with a polypeptide of the expected size. A second class of cDNAs encoded a polypeptide of 43 kDa which was closely related to the N‐terminal half of the 82 kDa protein. Northern blots showed two mRNAs of 4.2 and 2.4 kb that probably correspond to the two classes of cDNAs, as well as a third band of 1.3 kb. The sequence of the N‐terminal half of bovine poly(A) polymerase is 47% identical with the amino acid sequence of the corresponding part of yeast poly(A) polymerase. Homologies to other proteins are of uncertain significance.
Partitionnement dans les systèmes de gestion de données parallèles

Au cours des dernieres annees, le volume des donnees qui sont capturees et generees a explose. Les progres des technologies informatiques, qui fournissent du stockage a bas prix et une tres forte puissance de calcul, ont permis aux organisations d'executer des analyses complexes de leurs donnees et d'en extraire des connaissances precieuses. Cette tendance a ete tres importante non seulement pour l'industrie, mais a egalement pour la science, ou les meilleures instruments et les simulations les plus complexes ont besoin d'une gestion efficace des quantites enormes de donnees.Le parallelisme est une technique fondamentale dans la gestion de donnees extremement volumineuses car il tire parti de l'utilisation simultanee de plusieurs ressources informatiques. Pour profiter du calcul parallele, nous avons besoin de techniques de partitionnement de donnees efficaces, qui sont en charge de la division de l'ensemble des donnees en plusieurs partitions et leur attribution aux nœuds de calculs. Le partitionnement de donnees est un probleme complexe, car il doit prendre en compte des questions differentes et souvent contradictoires telles que la localite des donnees, la repartition de charge et la maximisation du parallelisme.Dans cette these, nous etudions le probleme de partitionnement de donnees, en particulier dans les bases de donnees paralleles scientifiques qui sont continuellement en croissance. Nous etudions egalement ces partitionnements dans le cadre MapReduce.Dans le premier cas, nous considerons le partitionnement de tres grandes bases de donnees dans lesquelles des nouveaux elements sont ajoutes en permanence, avec pour exemple une application aux donnees astronomiques. Les approches existantes sont limitees a cause de la complexite de la charge de travail et l'ajout en continu de nouvelles donnees limitent l'utilisation d'approches traditionnelles. Nous proposons deux algorithmes de partitionnement dynamique qui attribuent les nouvelles donnees aux partitions en utilisant une technique basee sur l'affinite. Nos algorithmes permettent d'obtenir de tres bons partitionnements des donnees en un temps d'execution reduit compare aux approches traditionnelles.Nous etudions egalement comment ameliorer la performance du framework MapReduce en utilisant des techniques de partitionnement de donnees. En particulier, nous sommes interesses par le partitionnement efficient de donnees d'entree
Fraudulent social media users detection by a supervised machine learning technique

With the vast growth of social media population and usage of Web 2.0 technologies, there is a need for detecting fraudulent, non-honest activities, and users online. Such users aim to manipulate other genuine users or promote specific products and services. The task of detecting such malevolent users or actions falls under the term of fraud detection. This thesis makes an examination of the past researches relevant to Twitter fraud detection, while studying the theoretical background that these techniques are based upon. Furthermore, the methodology that was followed in this thesis is presented, alongside the technologies that were used and the reasons they were chosen. Moreover, this thesis presents the proposed Twitter fraud detection framework which consists of several models. The analysis, evaluation and collation of these models is conferred and discussed. Additionally, we present and indicative platform implementation for social media fraud detection. The functionality of several core components of the platform are discussed and examined alongside the contribution for each component. In conclusion, the outcomes and opinions of this research are apposed, combined with the boundaries for future improvements and challenges in social media fraud detection.
Adverse effects of alpha 1-adrenergic blocking drugs.

Earlier nonselective alpha 1-adrenergic blocking drugs such as phentolamine and phenoxybenzamine are now restricted to the pharmacological management of alpha 1-adrenergic crisis and phaeochromocytoma. Prazosin, the first selective alpha 1-blocker approved for the treatment of hypertension, became available in the mid-1970s. Additional alpha 1-blockers such as doxazosin and terazosin have been introduced during recent years. The undesirable effects of all members of this class are similar. Most adverse events can be attributed to reversible competitive antagonism of postsynaptic alpha 1-adrenergic receptors in tissues that sustain high levels of alpha-adrenergic sympathetic tone, e.g. resistance arteries, capacitance veins and the urinary bladder outflow tract. Orthostatic hypotension with a sensation of intense faintness and occasional syncope, can occur shortly after the initial dose. Aggravating factors include upright posture, intravascular volume depletion and concurrent administration of other medications that lower blood pressure, including all other classes of antihypertensive drugs. The problem is reduced or avoided by the choice of low starting doses, beginning treatment at bedtime and by minimising other risks. Among overall adverse effects, asthenia, dizziness, faintness and syncope predominate and occur in 10 to 20% of patients, leading to discontinuation of therapy in about half that number. Infrequent adverse events include headache, drowsiness, palpitations, urinary incontinence and priapism. Some patients experience a 1 to 2kg bodyweight gain which may be associated with secondary hyperaldosteronism. Tolerance appears to develop to the benefits of alpha 1-blockade in patients with congestive heart failure, but not in hypertension. (ABSTRACT TRUNCATED AT 250 WORDS)
A study on emotion estimation of narratives using cognitive appraisals of the reader

Our emotion estimation refers to estimation of a reader's sentiments and feelings after they read a narrative (i.e., post-reading emotion types). The emotion types manifest in a reader's feelings combine to form diverse and various patterns. To elicit this phenomenon, we here attempt to estimate readers' emotional patterns based on their cognitive appraisals of the work. This paper describes our cognitive appraisal methodology, variation in readers' emotion types due to differences in their cognitive appraisals, and report and discuss the results of emotion estimation experiments in which a reader performs a cognitive appraisal of the text of a narrative.
High-resolution electron-beam patternable nanocomposite containing metal nanoparticles for plasmonics

Polymer nanocomposites containing noble metal nanoparticles are promising materials for plasmonic applications. In this paper, we report on a high-resolution negative-tone nanocomposite resist based on poly(vinyl alcohol) where silver nanoparticles and nanopatterns are simultaneously generated by electron-beam lithography. Our results indicate nanostructures with a relatively high concentration of nanoparticles and, consequently, an electromagnetic coupling among the nanoparticles. Therefore, the patternable nanocomposite described in this work may be a suitable material for future plasmonic circuitry.
Attachment and the Cognitive Schema 1 Running head: THE ADLERIAN VIEW OF ATTACHMENT AND THE COGNITVE

Degree of secure attachment is an important predictor of mental health at both early and late development periods. When insecure attachments occur between children and caregivers, adverse behavioral and emotional problems are often a result in childhood and adulthood. The developing cognitive schema is affected by attachment style during this critical period of early maturation. The developing cognitive schema that results from early experiences with caregivers influences adult interpretations of reality. This paper explores the interaction between early-life attachments and the Adlerian view regarding the construction of the cognitive schema. Recommendations are made as to how therapists can treat children, adolescents, and adults who suffer from attachment difficulties. Attachment and the Cognitive Schema 2a The Adlerian View of Attachment and Its Relationship to the Development of the Cognitive Schema
Automatic Video Analysis for Obstructive Sleep Apnea Diagnosis.

STUDY OBJECTIVES We investigated the diagnostic accuracy for the identification of obstructive sleep apnea (OSA) and its severity of a noninvasive technology based on image processing (SleepWise). METHODS This is an observational, prospective study to evaluate the degree of agreement between polysomnography (PSG) and SleepWise. We recruited 56 consecutive subjects with suspected OSA who were referred as outpatients to the Sleep Unit of the Hospital Universitari Germans Trias i Pujol (HUGTiP) from January 2013 to January 2014. All patients underwent laboratory PSG and image processing with SleepWise simultaneously the same night. Both PSG and SleepWise analyses were carried independently and blindly. RESULTS We analyzed 50 of the 56 patients recruited. OSA was diagnosed through PSG in a total of 44 patients (88%) with a median apnea-hypopnea index (AHI) of 25.35 (24.9). According to SleepWise, 45 patients (90%) met the criteria for a diagnosis of OSA, with a median AHI of 22.8 (22.03). An analysis of the ability of PSG and SleepWise to classify patients by severity on the basis of their AHI shows that the two diagnostic systems distribute the different groups similarly. According to PSG, 23 patients (46%) had a diagnosis of severe OSA, 11 patients (22%) moderate OSA, and 10 patients (20%) mild OSA. According to SleepWise, 20, 13, and 12 patients (40%, 26%, and 24%, respectively) had a diagnosis of severe, moderate, and mild OSA respectively. For OSA diagnosis, SleepWise was found to have sensitivity of 100% and specificity of 83% in relation to PSG. The positive predictive value was 97% and the negative predictive value was 100%. The Bland-Altman plot comparing the mean AHI values obtained through PSG and SleepWise shows very good agreement between the two diagnostic techniques, with a bias of -3.85, a standard error of 12.18, and a confidence interval of -0.39 to -7.31. CONCLUSIONS SleepWise was reasonably accurate for noninvasive and automatic diagnosis of OSA in outpatients. SleepWise determined the severity of OSA with high reliability. The current study including simultaneous laboratory PSG and SleepWise processing image is proposed as a reasonable validation standard.
Bibles and BioShock: Affording Religious Discussion on Video Game Forums

This study sets forth to analyze and categorize attitudes shown by communities of players on internet forums, debating religious worldviews in games such as BioShock and Assassin's Creed. It does so in light of the theo- and technological affordances that shape these discussions through the platforms of digital games and internet forums. Is the predominance of religion in games, as noted by other scholars, actually a topic of discussion for players themselves? And if so, which games afford discussion? What attitudes are displayed? And what are the motivations behind these attitudes? A multi-method approach is presented, analyzing 91 discussions and 20 interviews; rooted in extensive familiarization with the relevant games. Research outcomes include a typology of user attitudes, part of which actively seek out enchantment in the face of secularization. These are theorized in the context of two affordances: the theological affordances of some interactive systems to invite play with religious worldviews in a secularizing world; and the technological affordances of the internet forum as a platform that affords but shapes forum discourse.
Upper- and lower-bound path-loss modeling for indoor line-of-sight environments

This paper proposes a method to predict line-of-sight (LOS) path loss in buildings. We performed measurements in two different types of buildings at a frequency of 1.8 GHz and propose upper-and-lower bounds path loss models which depend on max and min values of sample path loss data. This makes our models limit path loss within the boundary lines. The models include time-variant effects such as people moving and cars in parking areas with their influence on wave propagation that is very high. The results have shown that the proposed models will be useful for the system and cell design of indoor wireless communication systems.
Cine MR fourier velocimetry of blood flow through cardiac valves: Comparison with doppler echocardiography

Noninvasive measurement of blood flow velocity through the cardiac valves has important clinical applications. A wide variety of MR methods are available for flow measurement. The aim of this study was to investigate the ability of cine MR Fourier velocimetry to measure flow through healthy cardiac valves and to compare MR and Doppler peak velocity measurements. Ten healthy volunteers (age mean ± SD, 24 ± 4 years) without history of valvular disease were studied. Four of the subjects were females. In each subject, aortic, pulmonary, mitral, and tricuspid valves were evaluated with MR and Doppler imaging. A whole‐body mobile MR machine was used, operating at . 5‐T with actively shielded magnetic field gradient coils on all three axes capable of 20 mT/m at a slew rate of 60 mT/m/msec. The heart rate during MR and Doppler studies was not significantly different. The mean difference between the two studies was 2 beats/min, with a 95% confidence interval of −22 beats/min, +25 beats/min. Peak systolic flow velocity in the aortic and pulmonary valves and peak diastolic flow velocity in the mitral and tricuspid valves measured with MRI and Doppler echocardiography correlated well. The mean difference between the two measurements (MR — Doppler) was 63 mm/sec, with a 95% confidence interval of −180 mm/sec, +310 mm/sec. The agreement between two observers interpreting the same MR velocity maps was close. The mean difference between their two measurements was 23 mm/sec, with a 95% confidence interval of −20 mm/sec, +60 mm/sec. There was no significant difference between MR and Doppler imaging or between the two MR observers. MR Fourier velocimetry has the necessary ease, reliability, and speed to measure blood flow through the cardiac valves, although measurement of late diastolic flow in the atrioventricular valves is limited. Measurement of peak blood velocity through the cardiac valves by this method showed satisfactory agreement with Doppler, but its clinical application for assessing diseased cardiac valves must be established.
Antioxidant, 5-Lipoxygenase Inhibitory and Cytotoxic Activities of Compounds Isolated from the Ferula lutea Flowers

A phytochemical investigation of the Ferula lutea (Poir.) Maire flowers has led to the isolation of a new compound, (E)-5-ethylidenefuran-2(5H)-one-5-O-β-d-glucopyranoside (1), designated ferunide, 4-hydroxy-3-methylbut-2-enoic acid (2), reported for the first time as a natural product, together with nine known compounds, verbenone-5-O-β-d-glucopyranoside (3), 5-O-caffeoylquinic acid (4), methyl caffeate (5), methyl 3,5-O-dicaffeoylquinate (6), 3,5-O-dicaffeoylquinic acid (7), isorhamnetin-3-O-α-l-rhamnopyranosyl(1→6)-β-d-glucopyranoside, narcissin (8), (−)-marmesin (9), isoimperatorin (10) and 2,3,6-trimethylbenzaldehyde (11). Compounds 3–10 were identified for the first time in Ferula genus. Their structures were elucidated by spectroscopic methods, including 1D and 2D NMR experiments, mass spectroscopy and X-ray diffraction analysis (compound 2), as well as by comparison with literature data. The antioxidant, anti-inflammatory and cytotoxic activities of isolated compounds were evaluated. Results showed that compound 7 exhibited the highest antioxidant activity with IC50 values of 18 ± 0.5 µmol/L and 19.7 ± 0.7 µmol/L by DPPH radical and ABTS radical cation, respectively. The compound 6 exhibited the highest anti-inflammatory activity with an IC50 value of 5.3 ± 0.1 µmol/L against 5-lipoxygenase. In addition, compound 5 was found to be the most cytotoxic, with IC50 values of 22.5 ± 2.4 µmol/L, 17.8 ± 1.1 µmol/L and 25 ± 1.1 µmol/L against the HCT-116, IGROV-1 and OVCAR-3 cell lines, respectively.
Low-cost low-maintenance paper-based sensor for the detection of Ebola virus

Recent outbreak of Ebola virus that causes hemorrhagic fever shows that the quick detection of this virus in a resource-poor environment is extremely important for controlling the epidemic. Existing methods based on enzyme-linked immunosorbent assay (ELISA), polymerase chain reaction (PCR) or isolation of the virus require expensive equipment, skilled personnel and the highest biosafety level. We highlight here a recent demonstration of low-cost low-maintenance synthetic biology for detection of Ebola virus based on paper as a device substrate.