Miracle-dz/UniFAR-FTUs huggingface dataset:
Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life

The purpose of this study was to investigate whether the anxiolytic effect of cannabidiol (CBD) in humans follows the same pattern of an inverted U-shaped dose-effect curve observed in many animal studies. Sixty healthy subjects of both sexes aged between 18 and 35 years were randomly assigned to five groups that received placebo, clonazepam (1 mg), and CBD (100, 300, and 900 mg). The subjects were underwent a test of public speaking in a real situation (TPSRS) where each subject had to speak in front of a group formed by the remaining participants. Each subject completed the anxiety and sedation factors of the Visual Analog Mood Scale and had their blood pressure and heart rate recorded. These measures were obtained in five experimental sessions with 12 volunteers each. Each session had four steps at the following times (minutes) after administration of the drug/placebo, as time 0: -5 (baseline), 80 (pre-test), 153 (speech), and 216 (post-speech). Repeated-measures analyses of variance showed that the TPSRS increased the subjective measures of anxiety, heart rate, and blood pressure. Student-Newman-Keuls test comparisons among the groups in each phase showed significant attenuation in anxiety scores relative to the placebo group in the group treated with clonazepam during the speech phase, and in the clonazepam and CBD 300 mg groups in the post-speech phase. Clonazepam was more sedative than CBD 300 and 900 mg and induced a smaller increase in systolic and diastolic blood pressure than CBD 300 mg. The results confirmed that the acute administration of CBD induced anxiolytic effects with a dose-dependent inverted U-shaped curve in healthy subjects, since the subjective anxiety measures were reduced with CBD 300 mg, but not with CBD 100 and 900 mg, in the post-speech phase.
An analysis of the effects of osmotic backwashing on the seawater reverse osmosis process

Fouling control is an important consideration in the design and operation of membrane-based water treatment processes. It has been generally known that chemical cleaning is still the most common method to remove foultants and maintain the performance of reverse osmosis (RO) desalination. Regardless of the chemical membrane cleaning methods applied effectively, however, frequent chemical cleaning can shorten the membrane life. In addition, it also increases operating and maintenance costs due to the waste chemical disposal. As an alternative, osmotic backwashing can be applied to RO membranes by diluting the concentration polarization (CP) layer. In this study, the effects of osmotic backwashing were analysed under different total dissolved salts (TDSs) and backwashing conditions, and the parameters of the osmotic backwashing were evaluated. The results of the analysis based on the properties of the organic matters found in raw water showed that the cleaning efficiency in respect to the fouling by hydrophilic organic matters was the greatest. Osmotic backwashing was carried out by changing the TDS of the permeate. As a result, the backwashing volume decreased with time due to the CP of the permeate and the backwashing volume. The difference in the osmotic pressure between the raw water and the permeate (Δ π) also decreased as time passed. It was confirmed that when the temperature of the effluent was high, both the cleaning efficiency and the backwashing volume, which inpours at the same time, increased. When the circulation flow of the effluent was high, both the cleaning efficiency and the backwashing volume increased.
Global pose localization of an autonomous wheeled mobile robot by fusing active RFID and ranging laser scanner: A fuzzy extended information filtering approach

The paper presents a global pose localization method for an autonomous mobile robot (AMR) in indoor environments by fusing measurements from an active RFID and a ranging laser scanner. The relations between the received signal strength indication data from a selected tag to a reader and the distances from the tag to the reader are established utilizing the curve-fitting method and the fuzzy weighted least-squares method at some typical working environments of the robot. A static global pose initialization algorithm is presented to estimate both the unknown start-up position and orientation of the autonomous mobile robot utilizing a fuzzy extended information filtering approach. A fuzzy extended information filtering pose tracking algorithm is then proposed to estimate the moving poses of the AMR. Simulations and experimental results are used to show the performance and merit of the proposed method.
A Simple Method for Land Surface Temperature Retrieval from AMSR-E

In this paper, we present a simple but efficient algorithm to derive land surface temperature (LST). The major point of our algorithm is to build linear regress equations between brightness temperature of AMSR-E and LST product from MODIS. Each equation corresponds to a group of land surface cells, within which the emissivities are similar. We found that for a given land surface type and a given latitude range, land surface emissivities are comparatively steady within a period (one month for example). In this way, we can separate all of the AMSR-E brightness temperature and MODIS LST product data into groups by land surface type, latitude range and date range. In each group, the regress equation can be build. We used 2004 data to build the regress equations and validated those used 2004 and 2006 data. We found that: 1, in snow covered area the accuracy of retrieved LST is poor. 2, in desert, accuracy of retrieval LST is also poor. 3, in other most land cover, retrieved LST by AMSR-E fit well with the MODIS LST product.
Hierarchical Voltage Control of a Wind Power Plant Using the Adaptive IQ-V Characteristic of a Doubly-Fed Induction Generator

Because wind generators (WGs) in a wind power plant (WPP) produce different active powers due to wake effects, the reactive power capability of each WG is different. This paper proposes a hierarchical voltage control scheme for a WPP that uses a WPP controller and WG controller. In the proposed scheme, the WPP controller determines a voltage error signal by using a PI controller and sends it to a doubly-fed induction generator (DFIG). Based on the reactive current-voltage (IQ-V) characteristic of a DFIG, the DFIG injects an appropriate reactive power corresponding to the voltage error signal. To enhance the voltage recovery capability, the gains of the IQ-V characteristic of a DFIG are modified depending on its reactive current capability so that a DFIG with greater reactive current capability may inject more reactive power. The proposed scheme enables the WPP to recover the voltage at the point of common coupling (PCC) to the nominal value within a short time after a disturbance by using the adaptive IQ-V characteristics of a DFIG. The performance of the proposed scheme was investigated for a 100 MW WPP consisting of 20 units of 5 MW DFIGs for small and larger disturbances. The results show the proposed scheme successfully recovers the PCC voltage within a short time after a disturbance.
To use the whip or not: Whether and when party group leaders use disciplinary measures to achieve voting unity

Party group leaders seemingly use a variety of disciplinary measures to achieve unified voting behavior in party groups. However, there is little systematic knowledge about the nature of such disciplinary measures and the interaction between leaders and group members remains a black box. Most studies of party voting concentrate on institutional variables such as electoral systems and take disciplinary measures as a given. This study presents a new way to measure party discipline, based on data from semi-structured interviews with 76 party group leaders and experts from five European parliaments. The discipline index provided here is the first to consider in a systematic way the means available to reprimand or reward party group members. In a second step, the study shows that disciplinary measures can compensate for a leader’s lack of control over candidate selection processes, and relate to group composition or size.
Multi-centre trial analysis revisited.

Analyses of multi-centre trials must consider the effects of the individual centres and the possibility of non-constancy of treatment effect differences among centres. This usually means an ANOVA with terms for centres, treatments, and centre x treatment interactions in practice, at least in the U.S.A. Empirical and conventional Bayes methods provide attractive alternatives to conventional ANOVAs for analysing and reporting the findings from multi-centre trials and do not require more restrictive assumptions than the ANOVA approach. These approaches require regarding the centre effects as random instead of fixed, a view which often will reasonably describe outcomes of clinical trials in spite of the fact that the individual centres certainly do not comprise a random sample of all possible centres. The components of these approaches are well understood and have been employed in related applications such as meta-analysis. Combining them in a way that makes their application to routine multi-centre trial analysis relatively straightforward does not appear to have been described previously, and is what forms the topic of this paper. The empirical Bayes approach leads to useful graphical displays, including one with the data superimposed on probability contours of the joint distribution of the individual centre means and standard deviations, which provides a handy way to identify possible outliers. Covariates can be incorporated without difficulty. The Bayes approach, implemented with Gibbs sampling, provides a convenient way to construct posterior and predictive distributions for a variety of useful statistics. We compare the result of empirical and conventional Bayes analyses with the result of fixed and mixed model ANOVAs applied to data from a multi-centre trial.
Designing and Applying a Nonparametric Option Valuation Model

This paper derives, tests and discusses a comprehensive and easy to use nonparametric option-valuation model, using a representative set of historical data on underlying asset returns jointly with an assumption of minimalistic implied information on current market trend and volatility expectations. Its testing on empirical data from Warsaw Stock Exchange trading for two distinct periods of 2014 suggests that such distribution-free models are capable of delivering useful market insights as well as applicability features, in particular wherever derivative markets are relatively new, incomplete, illiquid, or with regard to the valuation of real options.
Global Education Using Technology To Bring The World To Your Students

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Characterization of Al2O3 in High-Strength Mo Alloy Sheets by High-Resolution Transmission Electron Microscopy

Abstract A novel type of alumina (Al2O3)-doped molybdenum (Mo) alloy sheet was prepared by a hydrothermal method and a subsequent powder metallurgy process. Then the characterization of α-Al2O3 was investigated using high-resolution transmission electron microscopy as the research focus. The tensile strength of the Al2O3-doped Mo sheet is 43–85% higher than that of the pure Mo sheet, a very obvious reinforcement effect. The sub-micron and nanometer-scale Al2O3 particles can increase the recrystallization temperature by hindering grain boundary migration and improve the tensile strength by effectively blocking the motion of the dislocations. The Al2O3 particles have a good bond with the Mo matrix and there exists an amorphous transition layer at the interface between Al2O3 particles and the Mo matrix in the as-rolled sheet. The sub-structure of α-Al2O3 is characterized by a number of nanograins in the $\left[ {2\bar{2}1} \right]$ direction. Lastly, a new computer-based method for indexing diffraction patterns of the hexagonal system is introduced, with 16 types of diffraction patterns of α-Al2O3 indexed.
Clinical Outcome of a Novel Photodynamic Therapy Technique Using Acridine Orange for Synovial Sarcomas¶

Abstract Synovial sarcoma (SS) is one of common malignant soft-tissue tumors and is encountered most commonly in children and young adults. It frequently involves or invades major neurovascular structures and bones, and its local recurrence rate after simple resection has been reported to be as high as up to 80%. Because major nerves and vessels, as well as an adequate amount of bone, must be preserved to restore excellent limb function in cases of SS, a surgical technique entailing a low risk of local recurrence is needed. Based on the findings of recent experimental studies conducted by us using a mouse osteosarcoma model, we developed a novel therapeutic technique for SS, consisting of reduction surgery followed by photodynamic therapy using acridine orange (AO-PDT), with or without X-ray irradiation at 5 Gy. A preliminary study revealed that low-dose X-rays also excite AO like photons. After an initial study on cell cultures, this novel technique was applied to six cases of SS. A follow-up of the subjects to determine the clinical outcome revealed that none of the cases treated by AO-PDT, including the four cases treated by additional 5 Gy irradiation and the two cases not receiving any radiation, showed any evidence of recurrence or local/systemic complications during the follow-up period of 19–51 months after the surgery. Therefore, we believe that AO-PDT with 5 Gy irradiation may be an excellent novel therapeutic modality with reduction surgery to salvage excellent limb function in SS involving major nerves and vessels or bones.
Effects of para-aminobenzoic acid, insulin, and gentamicin on Plasmodium falciparum development in anopheline mosquitoes (Diptera: Culicidae).

Anopheles gambiae Giles sensu lato (s.l.) and An. stephensi Liston were exposed as adults to para-aminobenzoic acid (PABA), human insulin, or gentamicin sulfate, an antimicrobial solution, to determine their effects on Plasmodium falciparum Welch development to the oocyst stage. For both mosquito species, concentrations of PABA from 0.001 to 0.05% had no effect on either oocyst infection rates or oocyst densities. At higher concentrations, PABA-fed mosquitoes had decreased oocyst infection rates when they were exposed after, but not before, experimental infections. Insulin-fed mosquitoes had significantly higher oocyst infection rates than controls and increased oocyst densities in both An. gambiae s.l and An. stephensi. The most dramatic impact on parasite development was observed for mosquitoes fed on gentamicin. For An. gambiae s.l. fed 0.05% gentamicin, oocyst infection rates were 3.7-fold higher than in controls, whereas oocyst densities were 5.7 times greater than in controls. Anopheles stephensi fed on diets of 0.1% gentamicin had 2.4-fold higher infection rates and increased oocyst densities. Concentrations of gentamicin above 0.1% had deleterious effects on mosquito survival and their ability to digest blood meals. These findings provide insight into how antibiotics, hormones, and metabolites may affect the development of P. falciparum in An. gambiae s.l. and An. stephensi.
Data gathering, surveillance and human rights: recasting the debate

The nature and depth of internet surveillance has been revealed to be very different from what had previously been publically acknowledged or politically debated. There are critical ways in which the current debate is miscast, misleading and confused. Privacy is portrayed as an individual right, in opposition to a collective need for security. Data gathering and surveillance are portrayed as having an impact only on this individual right to privacy, rather than on a broad spectrum of rights, including freedom of expression, of assembly and association, the prohibition of discrimination and more. The gathering and surveillance of ‘content’ is intrinsically more intrusive than that of ‘communications’ data or ‘metadata’. The impact of data gathering and surveillance is often portrayed as happening only at when data are examined by humans rather than when gathered, or when examined algorithmically. Commercial and governmental data gathering and surveillance are treated as separate and different, rather than intrinsically and inextricably linked. This miscasting has critical implications. When the debate is recast taking into account these misunderstandings, the bar for the justification of surveillance is raised and a new balance needs to be found, in political debate, in law, and in decision-making on the ground.
Who Pays for the Health Benefits of Exclusive Breastfeeding? An Analysis of Maternal Time Costs

Background: The benefits of exclusive breastfeeding, including public health cost savings, are widely recognized, but breastfeeding requires maternal time investments. Objective: This study investigates the time taken to exclusively breastfeed at 6 months compared with not exclusively breastfeeding. Methods: Time use data were examined from an Australian survey of new mothers conducted during 2005-2006. Data from 139 mothers with infants age 6 months were analyzed using chi-square tests of independence to examine socioeconomic and demographic characteristics and 2-sided t tests to compare average weekly hours spent on milk feeding, feeding solids, preparing feeds, and the total of these. The comparison was of exclusively breastfeeding mothers with other mothers. We also compared exclusively breastfeeding with partially breastfeeding and formula feeding mothers using a 1-way between-groups analysis of variance (ANOVA). Results: The exclusively breastfeeding (vs other) mothers spent 7 hours extra weekly on milk feeding their infants but 2 hours less feeding solids. These differences were statistically significant. ANOVA revealed significant differences between exclusively breastfeeding mothers, breastfeeding mothers who had introduced solids, and mothers who fed any formula, in time spent feeding milk, and solids, and preparing feeds. Conclusion: Exclusive breastfeeding is time intensive, which is economically costly to women. This may contribute to premature weaning for women who are time-stressed, lack household help from family, or cannot afford paid help. Gaining public health benefits of exclusive breastfeeding requires strategies to share maternal lactation costs more widely, such as additional help with housework or caring for children, enhanced leave, and workplace lactation breaks and suitable child care.
Replication of simian virus 40 origin-containing DNA during infection with a recombinant Autographa californica multiple nuclear polyhedrosis virus expressing large T antigen

Autographica californica multiple nuclear polyhedrosis virus (AcMNPV) has been shown to encode many of the enzymes involved in the replication of its own DNA. Although the AcMNPV genome contains multiple sets of reiterated sequences that are thought to function as origins of DNA replication, no initiator protein has yet been identified in the set of viral replication enzymes. In this study, the ability of a heterologous origin initiator system to promote DNA replication in AcMNPV-infected cells was examined. A recombinant AcMNPV that expressed the simian virus 40 (SV40) large T antigen was surprisingly found to induce the efficient replication of a transfected plasmid containing an SV40 origin. This replication was subsequently found to involve three essential components: (i) T antigen, since replication of SV40 origin-containing plasmids was not induced by wild-type AcMNPV which did not express this protein; (ii) an intact SV40 core origin, since deletion of specific functional motifs within the origin resulted in a loss of replicative abilities; and (iii) one or more AcMNPV-encoded proteins, since viral superinfection was required for plasmid amplification. Characterization of the replicated DNA revealed that it existed as a high-molecular-weight concatemer and underwent significant levels of homologous recombination between inverted repeat sequences. These properties were consistent with an AcMNPV-directed mode of DNA synthesis rather than that of SV40 and suggested that T antigen-SV40 origin complexes may be capable of initiating DNA replication reactions that can be completed by AcMNPV-encoded enzymes.
Uncovering Small RNA-Mediated Responses to Cold Stress in a Wheat Thermosensitive Genic Male-Sterile Line by Deep Sequencing1[W][OA]

The male sterility of thermosensitive genic male sterile (TGMS) lines of wheat (Triticum aestivum) is strictly controlled by temperature. The early phase of anther development is especially susceptible to cold stress. MicroRNAs (miRNAs) play an important role in plant development and in responses to environmental stress. In this study, deep sequencing of small RNA (smRNA) libraries obtained from spike tissues of the TGMS line under cold and control conditions identified a total of 78 unique miRNA sequences from 30 families and trans-acting small interfering RNAs (tasiRNAs) derived from two TAS3 genes. To identify smRNA targets in the wheat TGMS line, we applied the degradome sequencing method, which globally and directly identifies the remnants of smRNA-directed target cleavage. We identified 26 targets of 16 miRNA families and three targets of tasiRNAs. Comparing smRNA sequencing data sets and TaqMan quantitative polymerase chain reaction results, we identified six miRNAs and one tasiRNA (tasiRNA-ARF [for Auxin-Responsive Factor]) as cold stress-responsive smRNAs in spike tissues of the TGMS line. We also determined the expression profiles of target genes that encode transcription factors in response to cold stress. Interestingly, the expression of cold stress-responsive smRNAs integrated in the auxin-signaling pathway and their target genes was largely noncorrelated. We investigated the tissue-specific expression of smRNAs using a tissue microarray approach. Our data indicated that miR167 and tasiRNA-ARF play roles in regulating the auxin-signaling pathway and possibly in the developmental response to cold stress. These data provide evidence that smRNA regulatory pathways are linked with male sterility in the TGMS line during cold stress.
FEAR CONDITIONING AND EXTINCTION IN YOUTH WITH OBSESSIVE‐COMPULSIVE DISORDER

Fear acquisition and extinction are central constructs in the cognitive‐behavioral model of obsessive–compulsive disorder (OCD), which underlies exposure‐based cognitive‐behavioral therapy (CBT). Youth with OCD may have impairments in fear acquisition and extinction that carry treatment implications. We examined these processes using a differential conditioning procedure.