Miracle-dz/UniFAR-FTUs huggingface dataset:
Test Review: Autism Spectrum Rating Scales

Goldstein, S. , & Naglieri, J. A. (2009). ASRS: Autism Spectrum Rating Scales. Toronto, Ontario, Canada: Multi-Health Systems. The Autism Spectrum Rating Scales (ASRS) are designed to measure behaviors in children between the ages of 2 and 18 that are associated with disorders on the autism spectrum as rated by parents/caregivers and/or teachers. The rating scales include items related to behaviors associated with Autism, Asperger’s Disorder, and Pervasive Developmental Disorder—Not Otherwise Specified (PDD-NOS). The ASRS are a norm-referenced tool based on the diagnostic criteria of ASDs in the Diagnostic and Statistical Manual of Mental Disorders (4th ed.), Text Revision (DSM-IV-TR; American Psychiatric Association, 2000).
TIMP-1 polymorphisms in a Chinese Han population with intracerebral hemorrhage

Remodeling of extracellular matrix (ECM) and breakdown of blood–brain barrier (BBB) are crucial events in the pathogenesis of intracerebral hemorrhage (ICH). Matrix metalloproteinases (MMPs), particularly MMP-9 and MMP-2, are the most important degrading enzymes in the ECM and BBB. These proteolytic effects are controlled predominantly by tissue inhibitors of metalloproteinases (TIMPs). TIMP-1 is the main endogenous inhibitor of MMP-9. Two polymorphisms in the TIMP-1 gene (rs4898 and rs2070584) were selected through a literature review and successfully genotyped in a study sample of 410 ICH patients and 305 controls. Differences in genotype and allele frequencies of identified polymorphisms were determined. Furthermore, the serum levels of TIMP-1 were measured in a subgroup of 96 ICH patients on days 1 after ICH onset and 76 controls. Analyses showed that C allele of rs2070584 was significantly associated with the development of ICH in male subjects (p = 0.037, OR = 1.535, 95%CI 1.025–2.300). Multiple logistic regression analysis under three genetic models demonstrated both rs4898 and rs2070584 were not risk factors for ICH in female subjects. Furthermore, serum levels of TIMP-1 were significantly higher in ICH patients than those in normal controls. However, the serum levels of TIMP-1 showed a nonsignificant decrease, depending on the alleles and genotypes of rs2070584 both in male and female cases. In conclusion, this is the first association study of the TIMP-1 gene variants with ICH. Our data suggest that C allele of rs2070584 is a risk factor for ICH development in the Chinese male population. However, the precise function of this variant needs further investigation.
Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative Metabolites in Serum of Thoroughbred Horses

The present study aimed to clarify changes of oxidative stress and antioxidative functions in treadmill-exercised Thoroughbred horses (n=5, 3 to 7 years old), using recently developed techniques for measurement of serum d-ROMs for oxidative stress, and BAP for antioxidative markers. Also, the effect of nasogastric administration of hydrogen-rich water (HW) or placebo water preceding the treadmill exercise on these parameters was examined. Each horse was subjected to a maximum level of treadmill exercise in which the horses were exhausted at an average speed of 13.2 ± 0.84 m/sec. Blood samples were taken 4 times, immediately before the intake of HW or placebo water at 30 min preceding the treadmill exercise, immediately before the exercise (pre-exercise), immediately after the exercise (post-exercise) and at 30 min following the exercise. In all horses, both d-ROMs and BAP values significantly increased at post-exercise. The increase in d-ROMs tended to be lower in the HW trial, as compared to the placebo trial at pre-exercise. The increase in BAP was considerable at approximately 150% of the pre-exercise values in both the HW and placebo treatment trials. The BAP/d-ROMs ratio was significantly elevated at post-exercise in both treatment trials, while a significant elevation was also observed at pre-exercise in the HW trial. BAP, d-ROM, and the BAP/d-ROM ratio tended to decline at 30 min after the exercise, except BAP and BAP/d-ROMs in the placebo trial. These results demonstrate that the marked elevation of oxidative stress and anitioxidative functions occurred simultaneously in the intensively exercised horses, and suggest a possibility that HW has some antioxidative efficacy.
Toward personalized peer-to-peer top-k processing

We present the first personalized peer-to-peer top-k search protocol for a collaborative tagging system. Each peer maintains relevant personalized information about its tagging behavior as well as that of its social neighbors, and uses those to locally process its queries. Extensive experiments based on a real-world dataset crawled from del.icio. us shows that very little storage at each peer suffices to get almost the same results as a hypothetical centralized solution with infinite storage.
Remote ischaemic conditioning on recipients of deceased renal transplants, effect on immediate and extended kidney graft function: a multicentre, randomised controlled trial protocol (CONTEXT)

Introduction Delayed graft function due to ischaemia-reperfusion injury is a frequent complication in deceased donor renal transplantation. Experimental evidence indicates that remote ischaemic conditioning (RIC) provides systemic protection against ischaemia-reperfusion injury in various tissues. Methods and analysis ‘Remote ischaemic conditioning in renal transplantation—effect on immediate and extended kidney graft function’ (the CONTEXT study) is an investigator initiated, multicentre, randomised controlled trial investigating whether RIC of the leg of the recipient improves short and long-term graft function following deceased donor kidney transplantation. The study will include 200 kidney transplant recipients of organ donation after brain death and 20 kidney transplant recipients of organ donation after circulatory death. Participants are randomised in a 1:1 design to RIC or sham-RIC (control). RIC consists of four cycles of 5 min occlusion of the thigh by a tourniquet inflated to 250 mm Hg, separated by 5 min of deflation. Primary end point is the time to a 50% reduction from the baseline plasma creatinine, estimated from the changes of plasma creatinine values 30 days post-transplant or 30 days after the last performed dialysis post-transplant. Secondary end points are: need of dialysis post-transplant, measured and estimated-glomerular filtration rate (GFR) at 3 and 12 months after transplantation, patient and renal graft survival, number of rejection episodes in the first year, and changes in biomarkers of acute kidney injury and inflammation in plasma, urine and graft tissue. Ethics and dissemination The study is approved by the local ethical committees and national data security agencies. Results are expected to be published in 2016. Trial registration number NCT01395719.
Drebrin preserves endothelial integrity by stabilizing nectin at adherens junctions

Summary Regulation of cell–cell contacts is essential for integrity of the vascular endothelium. Here, a critical role of the F-actin-binding protein drebrin in maintaining endothelial integrity is revealed under conditions mimicking vascular flow. Drebrin knockdown leads to weakening of cell–cell contacts, characterized by loss of nectin from adherens junctions and its subsequent lysosomal degradation. Immunoprecipitation, FRAP and mitochondrial re-targeting experiments show that nectin stabilization occurs through a chain of interactions: drebrin binding to F-actin, interaction of drebrin and afadin through their polyproline and PR1-2 regions, and recruitment of nectin through the PDZ region of afadin. Key elements are modules in drebrin that confer binding to afadin and F-actin. Evidence for this was obtained using constructs containing the PDZ region of afadin coupled to the F-actin-binding region of drebrin or to lifeact, which restore junctional nectin under knockdown of drebrin or of both drebrin and afadin. Drebrin, containing binding sites for both afadin and F-actin, is thus uniquely equipped to stabilize nectin at endothelial junctions and to preserve endothelial integrity under vascular flow.
Mobility prediction in wireless networks

Wireless networks allow a more flexible communication model than traditional networks since the user is not limited to a fixed physical location. Unlike cellular wireless networks, ad hoc wireless networks do not have any fixed communication infrastructure. In ad hoc networks, routes are mostly multihop and network hosts communicate via packet radios. Each host moves in an arbitrary manner and thus routes are subject to frequent disconnections. In typical mobile networks, nodes exhibit some degree of regularity in the mobility pattern. By exploiting a mobile user's non-random traveling pattern, we can predict the future state of network topology and thus provide a transparent network access during the period of topology changes. In this paper we present various enhancements to unicast and multicast routing protocols using mobility prediction. The proposed scheme utilizes GPS location information. By simulation, we evaluate the effectiveness of mobility prediction.
Human PIF Helicase is Cell Cycle Regulated and Associates with Telomerase

The evolutionarily conserved PIF1 DNA helicase family is important for the maintenance of genome stability in the yeast, Saccharomyces cerevisiae. There are two PIF1 family helicases in S. cerevisiae, Pif1p and Rrm3p that both possess 5’→3’ DNA helicase activity but maintain unique functions in telomerase regulation and semi-conservative DNA replication. Database analysis shows that the PIF1 helicase family is represented by a single homologue in higher eukaryotes. To analyze the function of PIF1 homologues in mammals, we cloned the full length human PIF (hPIF) cDNA. Comparison of hPIF with its S. cerevisiae homologues showed that human PIF is equally similar to Pif1p and Rrm3p. Human PIF1 was expressed at low levels in a variety of tissues and immunofluorescence analysis showed that ectopic hPIF1 was localized to nuclear foci. hPIF was expressed in late S/G2 phase of the cell cycle and this cell cycle regulated abundance was conferred by both cell cycle regulated mRNA accumulation and ubiquitin-mediated degradation. Furthermore, hPIF is likely a target of the anaphase promoting complex/cyclosome as its abundance was decreased when an activator of the APC/C was over-expressed. Finally, antibodies against hPIF immunoprecipitated telomerase activity from human cell lines, and we have observed a physical interaction between hPIF and the catalytic subunit of telomerase, hTERT. Our data suggest that human PIF, like S. cerevisiae Pif1p, plays a role in telomerase regulation.
LARGE EDDY SIMULATION OF CHEMICAL PROCESSES CARRIED OUT IN JET REACTORS

The method of Large Eddy Simulation (LES) is applied in this work to simulate the course of complex processes in the non-premixed, turbulent reactive flows of incompressible fluids. Effects of mixing on various scales on quality of final products for parallel reactions and precipitation processes are investigated. To achieve the high mixing efficiencies two jet reactors are employed.
How Small Labels Create Big Improvements

It is widely believed that identifying communities in an ad hoc mobile communications system, such as a pocket switched network, can reduce the amount of traffic created when forwarding messages, but there has not been any empirical evidence available to support this assumption to date. In this paper, we show through use of real experimental human mobility data, how using a small label, identifying users according to their affiliation, can bring a large improvement in forwarding performance, in term of both delivery ratio and cost
Stability Analysis of Simplex Architecture Controlled Inverted Pendulum

Switched controllers are being used frequently for control of complex systems. However, they introduce new challenges for verification of stability, of which a great deal of work in the hybrid systems domain has been formalizing recently. This work is a stability case study of the classical inverted pendulum, in this case controlled using the Simplex architecture of [1], combining to form a complete system as in [2]. The main result shown uses small-gain theorems to prove the stability of the system with regards to measurement delays.
Defending Community: The Struggle for Alternative Redevelopment in Cedar-Riverside

Preface Abbreviations Map of Cedar-Riverside 1. Capital, Community, and Cedar-Riverside: An Overview 2. Capital Invades Cedar-Riverside 3. A New Community Forms Against the New Town 4. Building on Community: Organizing the Resistance 5. The Growth Coalition Falters 6. Building the Foundation for Community-Based Development 7. The Struggle Within 8. The Role of Community in Urban Insurgency 9. The Limits and the Potential of Community Control of Urban Redevelopment 10. The Legacy of Cedar-Riverside Appendix: Interviewees and Interviews Notes References Bibliography of Newspapers and Newsletters Index
Auxin regulates first leaf development and promotes the formation of protocorm trichomes and rhizome-like structures in developing seedlings of Spathoglottis plicata (Orchidaceae)

This work demonstrated that auxin plays an important role in seedling establishment of the orchid S. plicata. In particular, normal first leaf formation required an appropriate distribution and concentration of auxin, as revealed by the use of polar auxin transport inhibitors and exogenously applied auxin. Moreover, auxin promoted the precocious formation of protocorm trichomes, which are an essential part of normal orchid seedling development. In addition, this work revealed that auxin can induce orchid seedlings to form propagative structures that are specific to a particular stage in seedling development.
Learning and evaluating response prediction models using parallel listener consensus

Traditionally listener response prediction models are learned from pre-recorded dyadic interactions. Because of individual differences in behavior, these recordings do not capture the complete ground truth. Where the recorded listener did not respond to an opportunity provided by the speaker, another listener would have responded or vice versa. In this paper, we introduce the concept of parallel listener consensus where the listener responses from multiple parallel interactions are combined to better capture differences and similarities between individuals. We show how parallel listener consensus can be used for both learning and evaluating probabilistic prediction models of listener responses. To improve the learning performance, the parallel consensus helps identifying better negative samples and reduces outliers in the positive samples. We propose a new error measurement called fConsensus which exploits the parallel consensus to better define the concepts of exactness (mislabels) and completeness (missed labels) for prediction models. We present a series of experiments using the MultiLis Corpus where three listeners were tricked into believing that they had a one-on-one conversation with a speaker, while in fact they were recorded in parallel in interaction with the same speaker. In this paper we show that using parallel listener consensus can improve learning performance and represent better evaluation criteria for predictive models.
Resonant Overvoltage Phenomena Caused by Transmission Line Faults

Resonant overvoltages in EHV transformers can be initiated by transmission line faults. A series of field tests were performed on the 151 mile long Kammer-Marysville 765 kV line in which a sequence of single line to ground faults were applied to one outside phase at 4 different locations. Fault location criteria and fault initiation procedures are presented. Oscillograms recorded the 3 phase response at both terminals of the line; one is transformer terminated, the other is open-ended. A frequency spectrum analysis of the waveforms is provided showing transient frequencies of sufficient magnitude and duration near the EHV transformer's resonant frequency to stimulate internal winding resonant overvoltages. Digital computer studies are presented and agree with the field tests quite favorably.
A Protograph Construction for LDPC Unequal Error Protection Codes

We introduce a new algorithm for constructing LDPC codes based on a Protograph. With Protographs, we have a base graph (mother graph), which is duplicated a number of times followed by a special edge permutation obtaining the largest possible girth. This report presents an algorithm for choosing the permutations for girth maximization given a degree distribution and the corresponding mother graph.
Multi-dimensional Annotation and Alignment in an English-German Translation Corpus

This paper presents the compilation of the CroCo Corpus, an English-German translation corpus. Corpus design, annotation and alignment are described in detail. In order to guarantee the searchability and exchangeability of the corpus, XML stand-off mark-up is used as representation format for the multi-layer annotation. On this basis it is shown how the corpus can be queried using XQuery. Furthermore, the generalisation of results in terms of linguistic and translational research questions is briefly discussed.
The Zinc RING Finger of Bovine Herpesvirus 1-Encoded bICP0 Protein Is Crucial for Viral Replication and Virulence

ABSTRACT Bovine herpesvirus 1 (BHV-1) infected cell protein 0 (bICP0) stimulates productive infection, in part by activating viral gene expression. The C3HC4 zinc RING finger of bICP0 is crucial for activating viral transcription and productive infection. In this study, we used a bacterial artificial chromosome containing a wild-type (wt) virulent BHV-1 strain to generate a single amino acid mutation in the C3HC4 zinc RING finger of bICP0. This virus (the 51g mutant) contains a cysteine-to-glycine mutation (51st amino acid) in the C3HC4 zinc RING finger of bICP0. A plasmid expressing the 51g mutant protein did not transactivate viral promoter activity as efficiently as wt bICP0. The 51g mutant virus expressed higher levels of the bICP0 protein than did the 51g rescued virus (51gR) but yielded reduced virus titers following infection of permissive bovine cells. The 51g mutant virus, but not the 51gR virus, grew poorly in bovine cells pretreated with imiquimod to stimulate interferon production. During acute infection of calves, levels of infectious virus were 2 to 3 logs lower in ocular or nasal swabs with 51g than with 51gR. Calves latently infected with the 51g mutant did not reactivate from latency because virus shedding did not occur in ocular or nasal cavities. As expected, calves latently infected with 51gR reactivated from latency following dexamethasone treatment. These studies demonstrate that mutation of a single well-conserved cysteine residue in the C3HC4 zinc RING finger of bICP0 has dramatic effects on the growth properties of BHV-1.
An Intelligent Artificial System : Artificial Immune based Hybrid Genetic Algorithm for the Vehicle Routing Problem

: Vehicle routing problems are well-known combinational optimization problems with considerable economic signiﬁcance. Considering the vehicle routing problem with limited capacity on tree is a problem that often naturally arises in railway, river, and rural road networks. In this paper, we describe an artiﬁcial immune system that is distributed, robust, dynamic, diverse and adaptive. It captures many features of the vertebrate immune system and proposed an intelligent artiﬁcial system which hybrid genetic and immune algorithm to solve the vehicle routing problem with limited capacity on tree. Computational results show the proposed technique to be very competitive with the best-known heuristic routing procedures providing some new best-known solutions.
Angry and Beautiful: The Interactive Effect of Facial Expression and Attractiveness on Time Perception

Time perception is an adaptive phenomenon that enables everyday functioning, although many of its aspects remain unknown. Previous studies have resulted in new insights regarding this phenomenon, indicating an overestimation of emotional faces presentations, compared to neutral ones. The aim of the present study was to explore if this effect due to emotional expression would be modulated by the attractiveness of the perceived face. Female participants performed a temporal bisection task during which they evaluated elapsed time of female faces presentation differing in facial expression (angry and neutral expression) and attractiveness (attractive and unattractive face) for seven different stimuli durations (400-1.600 ms). Results indicate a systematic overestimation of angry faces duration compared to neutral ones, but only for the attractive face condition, the effect that did not occur for the unattractive face. These findings support the arousal-based models of time perception, indicating that arousal affects time perception mechanism resulting in an overestimation of the perceived time.
Podocytes Regulate Neutrophil Recruitment by Glomerular Endothelial Cells via IL-6–Mediated Crosstalk

Stromal cells actively modulate the inflammatory process, in part by influencing the ability of neighboring endothelial cells to support the recruitment of circulating leukocytes. We hypothesized that podocytes influence the ability of glomerular endothelial cells (GEnCs) to recruit neutrophils during inflammation. To address this, human podocytes and human GEnCs were cultured on opposite sides of porous inserts and then treated with or without increasing concentrations of TNF-α prior to addition of neutrophils. The presence of podocytes significantly reduced neutrophil recruitment to GEnCs by up to 50% when cultures were treated with high-dose TNF-α (100 U/ml), when compared with GEnC monocultures. Importantly, this phenomenon was dependent on paracrine actions of soluble IL-6, predominantly released by podocytes. A similar response was absent when HUVECs were cocultured with podocytes, indicating a tissue-specific phenomenon. Suppressor of cytokine signaling 3 elicited the immunosuppressive actions of IL-6 in a process that disrupted the presentation of chemokines on GEnCs by altering the expression of the duffy Ag receptor for chemokines. Interestingly, suppressor of cytokine signaling 3 knockdown in GEnCs upregulated duffy Ag receptor for chemokines and CXCL5 expression, thereby restoring the neutrophil recruitment. In summary, these studies reveal that podocytes can negatively regulate neutrophil recruitment to inflamed GEnCs by modulating IL-6 signaling, identifying a potential novel anti-inflammatory role of IL-6 in renal glomeruli.