Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Network Human Capital on Economic Growth of Supply Chain in Digital Economy

Abstract- The article reveals the features of the neural-network technological revolution and digital economy development. They substantiate the proposition that in the modern digital economy new informational-network properties and the competences of highly skilled workers are developed and human capital is transformed into network human capital. The definition of "network human capital" concept is given and its basic properties are revealed. The available methodological approaches are summarized in the economic literature to study the influence of human capital and labor quality on productivity and economic growth of supply chain. They reveal the methodical problems of investment in education quantitative evaluation and their return is determined. They substantiate the thesis that the digital economy has various neuro-network effects from the use of network human capital in the digital neuro-network economy and it is concluded that they need to be evaluated, recorded and included in the gross national product.
ADVANCES IN RISKING EXPLORATION PROSPECTS

Assessment of prospect risk is a vital exploration activity, but technical literature on the subject shows few advances in methodologies in the last 20 years. Origin Energy has found that published procedures are not always adequate. Three perceived shortcomings are examined and techniques are proposed to overcome them. Cases where prospect risk is dependent on reserve size. Traditional methodologies assume the two are independent. This assumption is clearly inappropriate for, say, a prospect for which the success case value is based on the mapped closure, but which has suspect seal capacity that may limit the column height to something less than full-to-spill. A way forward is to build a variable risk array for a range of column heights and calculate the incremental risked NPV for each layer. The expected monetary value (EMV) is computed for a range of column heights based on the NPV of cumulative risked reserves; Cases where the estimation of chance of success (COS) based on traditional geological information needs to be combined with direct hydrocarbon indicators (DHIs) from seismic data. DHIs are not infallible indicators, however, and cannot be used to set the COS for elements such as charge to say 100%. Bayes’ Theorem can be used to combine the two sets of uncertain information. Cases where prospects are risked on very limited data. Traditional risking does not adequately incorporate the level of knowledge on which risk assessments are made. Inadequacies are identified in existing methodologies, but no simple and satisfactory solutions can be identified. We do suggest a way forward, however, for a related problem—testing the sensitivity of the EMV calculation for an exploration prospect for uncertainties in COS.
Food price volatilities and civilian victimization in Africa

This paper studies the impact of food insecurity on civilian–rebel interactions. We argue that food price volatilities affect the incentives of insurgent groups and their subsequent treatment of civilians. The hypotheses developed in this study are empirically evaluated across a battery of statistical models using monthly data from a sample of 112 first administrative districts in sub-Saharan Africa. The results show that increases in food insecurity substantially raise the likelihood of insurgent groups committing violence against civilians and that districts with a higher proportion of agricultural land are at greatest risk of civilian victimization by rebel groups during these episodes of food insecurity. The implications of this analysis suggest that the human impact of food insecurity does not simply relate to nutrition and questions of governance. Food price volatilities also incentivize the use of violence against civilians by non-state actors, which is a pertinent concern of human rights organizations and policymakers.
Aminoglycoside 6′-N-Acetyltransferase Variants of the Ib Type with Altered Substrate Profile in Clinical Isolates of Enterobacter cloacae and Citrobacter freundii

ABSTRACT Three clinical isolates, Enterobacter cloacae EC1562 and EC1563 and Citrobacter freundii CFr564, displayed an aminoglycoside resistance profile evocative of low-level 6′-N acetyltransferase type II [AAC(6′)-II] production, which conferred reduced susceptibility to gentamicin but not to amikacin or isepamicin. Aminoglycoside acetyltransferase assays suggested the synthesis in the three strains of an AAC(6′) which acetylated amikacin practically as well as it acetylated gentamicin in vitro. Both compounds, however, as well as isepamicin, retained good bactericidal activity against the three strains. The aacgenes were borne by conjugative plasmids (pLMM562 and pLMM564 of ca. 100 kb and pLMM563 of ca. 20 kb). By PCR mapping and nucleotide sequence analysis, an aac(6′)-Ib gene was found in each strain upstream of an ant(3")-I gene in asulI-type integron. The size of the AAC(6′)-Ib variant encoded by pLMM562 and pLMM564, AAC(6′)-Ib7, was deduced to be 184 (or 177) amino acids long, whereas in pLMM563 a 21-bp duplication allowing the recruitment of a start codon resulted in the translation of a variant, AAC(6′)-Ib8, of 196 amino acids, in agreement with size estimates obtained by Western blot analysis. Both variants had at position 119 a serine instead of the leucine typical for the AAC(6′)-Ib variants conferring resistance to amikacin. By using methods that predict the secondary structure, these two amino acids appear to condition an α-helical structure within a putative aminoglycoside binding domain of AAC(6′)-Ib variants.
Ultradian rhythm of trehalose levels coupled to heat resistance in continuous cultures of the yeast Saccharomyces cerevisiae

Heat resistance appears to cycle in concert with energy metabolism in continuous culture of the yeast Saccharomyces cerevisiae. To study the mechanism of this oscillation, the authors first examined if heat shock proteins (Hsps) are involved. Neither the protein levels of major Hsps nor the expression of the β-galactosidase gene as a reporter under the control of the promoter carrying heat-shock element oscillated during the metabolic oscillation. The level of trehalose in yeast cycled with the same periodicity, as did energy metabolism. This oscillation was not found in a GTS1-deleted mutant that also did not show cyclic changes in heat resistance. These results suggest that heat resistance oscillation is induced by fluctuations in trehalose level and not by an oscillatory expression of Hsps. The increase in trehalose began at the start of the respiro-fermentative phase and the decrease began after the elevation of the cyclic adenosine monophosphate (cAMP) level. The authors hypothesize that the synthesis of trehalose parallels the activation of the glycolytic pathway and that trehalose is degraded by trehalase activated by cAMP coupled with the metabolic oscillation in the continuous culture of yeast.
Nuclear envelope and chromatin compositional differences comparing undifferentiated and retinoic acid- and phorbol ester-treated HL-60 cells.

The human leukemic cell line (HL-60) can be induced to differentiate in vitro to granulocytic form with retinoic acid (RA), or to monocytic/macrophage form with phorbol ester (TPA). The granulocytic form acquires nuclear lobulation, nuclear envelope-limited chromatin sheets (ELCS), and cytoskeletal polarization, none of which are acquired following treatment with TPA. Immunoblotting analyses and capillary zone electrophoresis demonstrated that following RA treatment: lamins A/C and B1, and vimentin decreased to negligible amounts; LAP2 beta, lamin B2 and emerin remained essentially unchanged; lamin B receptor (LBR) increased markedly; histone subtypes H1.4 and 1.5 exhibited dephosphorylation. Following TPA treatment: lamins A/C and B1, B2 and vimentin increased in amount; LAP2 beta and emerin remained essentially unchanged; LBR increased markedly; histone subtypes H1.4 and 1.5 exhibited dephosphorylation. Emerin, which was cytoplasmic in undifferentiated or granulocytic cells, localized into the nuclear envelope following TPA. Normal human granulocytes revealed compositional differences compared to granulocytic forms of HL-60, namely increased vimentin and appearance of histone subtype H1.3. A working hypothesis for nuclear lobulation postulates a combination of: increased nuclear envelope deformability due to lamins A/C and B1 deficiency; an increase in nuclear surface area/volume; an increase in chromatin-nuclear envelope interactions.
Selective weight setting algorithm in cognitive radio network under resource limitation

The ever-increasing demand for higher data rates in wireless communications in the face of inadequate or underutilized spectral resources has motivated the introduction of cognitive radio. In cognitive radio network, unlicensed users continuously scan a vast range of frequencies to detect `white spaces' or `spectrum holes' that are temporarily and spatially not being used by licensed user, process of which is commonly known as spectrum sensing. In order to implement the cooperative spectrum sensing among Cognitive Radio (CR) users, data fusion schemes are superior to that of decision fusion ones in terms of detection performance but suffer from the drawback of huge traffic overhead when restriction of bandwidth of communication channels and energy consumption of the radio network comes into consideration. In this paper, a combination of data and decision fusion approach is implemented to mutually adventure the advantages of both and a selective weight setting algorithm is proposed by utilizing normal and modified deflection coefficients maximization under Neyman-Pearson criterion in order to obtain a final decision. Also, cluster-based Cooperative Spectrum Sensing (CSS) has been proposed in cognitive radio network to improve the energy efficiency. The simulations show promising results as the hybridization process visibly reduces the network traffic overhead while attaining a highly reasonable detection performance.
Multi-Resolution Design for Large-Scale and High-Resolution Monitoring

Large-scale and high-resolution monitoring systems are ideal for many visual surveillance applications. However, existing approaches have insufficient resolution and low frame rate per second, or have high complexity and cost. We take inspiration from the human visual system and propose a multi-resolution design, e-Fovea, which provides peripheral vision with a steerable fovea that is in higher resolution. In this paper, we firstly present two user studies, with a total of 36 participants, to compare e-Fovea to two existing multi-resolution visual monitoring designs. The user study results show that for visual monitoring tasks, our e-Fovea design with steerable focus is significantly faster than existing approaches and preferred by users. We then present our design and implementation of e-Fovea, which combines both multi-resolution camera input and multi-resolution steerable projector output. Finally, we present our deployment of e-Fovea in three installations to demonstrate its feasibility.
High-speed, low-power InSb transistors

High-speed, low-power consumption field-effect transistors fabricated from InSb/In/sub 1-x/Al/sub x/Sb are demonstrated. A 0.7 /spl mu/m gate-length enhancement-mode device shows an f/sub T/, of 74 GHz, and an f/sub max/ of 89 GHz, at a drain voltage below 0.5 V. This is the fastest reported transistor for its gate length, as far as is known.
An evidence-based systematic review of amplitude compression in hearing aids for school-age children with hearing loss.

PURPOSE Two clinical questions were developed: one addressing the comparison of linear amplification with compression limiting to linear amplification with peak clipping, and the second comparing wide dynamic range compression with linear amplification for outcomes of audibility, speech recognition, speech and language, and self- or parent report in children with hearing loss. METHOD Twenty-six databases were systematically searched for studies addressing a clinical question and meeting all inclusion criteria. Studies were evaluated for methodological quality, and effect sizes were reported or calculated when possible. RESULTS The literature search resulted in the inclusion of 8 studies. All 8 studies included comparisons of wide dynamic range compression to linear amplification, and 2 of the 8 studies provided comparisons of compression limiting versus peak clipping. CONCLUSIONS Moderate evidence from the included studies demonstrated that audibility was improved and speech recognition was either maintained or improved with wide dynamic range compression as compared with linear amplification. No significant differences were observed between compression limiting and peak clipping on outcomes (i.e., speech recognition and self-/parent report) reported across the 2 studies. Preference ratings appear to be influenced by participant characteristics and environmental factors. Further research is needed before conclusions can confidently be drawn.
Congenital Entropion: Outcome of Posterior Layer Advancement of Lower Eyelid Retractors and Histological Study of Orbicularis Oculi Muscle Hypertrophy

Abstract Purpose: To examine surgical outcomes of the posterior layer advancement of the lower eyelid retractors (LER) in patients with congenital entropion and to ascertain whether the pretarsal orbicularis oculi muscle (OOM) was hypertrophic or not. Materials and Methods: This retrospective study included three Japanese patients with congenital entropion who underwent posterior layer advancement of the LER. We reviewed the surgical outcomes and postoperative complications, such as lower eyelid ectropion and retraction for each patient. We also measured the diameters of the pretarsal OOM fibers in these patients and compared them with those measured in the previously reported 67 eyelids of 41 Japanese patients with congenital epiblepharon. Results: Congenital entropion was successfully corrected in all three patients without recurrence during 12-months of follow-up. No patient exhibited lower eyelid ectropion or lower eyelid retraction. The mean diameter of the pretarsal OOM fibers was 21.9 μm (range, 20.5–23.7 μm), which was not significantly different from that of the congenital epiblepharon (25.3 μm; range, 18.1–34.7 μm; p = 0.272, Mann–Whitney U test). Conclusions: The surgical outcomes in the present study suggest that posterior layer advancement of the LER is a useful surgical option for treatment of congenital entropion. No histological evidence of pretarsal OOM hypertrophy was shown in congenital entropion, which demonstrated that debulking of the pretarsal OOM may not be significant for correction of this entity.
The Function of Ascorbate Oxidase in Tobacco1

The function of the apoplastic enzyme ascorbate oxidase (AO) was investigated in tobacco (Nicotiana tabacum). The abundance of AO mRNA was up-regulated by light. Cytosolic ascorbate peroxidase (APX1) transcripts were also highest in the light. In contrast, l-galactono-γ-lactone dehydrogenase, stromal APX, and thylakoid APX transcripts remained constant over the day/night cycle. Salicylic acid inhibited growth, increased expression of the pathogenesis-related protein (PR) 1a, and decreased AO transcript abundance. In contrast, the application of auxin enhanced growth and increased AO and PR 1a gene expression. Therefore, AO transcript abundance varied in a manner similar to hormone-mediated changes in plant growth. To study the effects of modified AO expression on growth, transformed tobacco plants expressing AO in the sense and antisense orientations were generated. The resultant large changes in apoplastic AO activity in the transformed tobacco plants had little effect on whole leaf ascorbate (AA) content, but they had dramatic effects on apoplastic AA levels. Enhanced AO activity oxidized the apoplastic AA pool, whereas decreased AO activity increased the amount of AA compared with dehydroascorbate. A relationship was observed between AO activity and plant height and biomass. Native AO transcript levels were no longer subject to light/dark regulation in AO sense and antisense plants. Taken together, these data show that there is an interaction between hormone, redox, and light signals at the level of the apoplast via modulation of ion of AA content.
Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study.

OBJECTIVE To investigate the effects of: I) short- (8 weeks), II) long-term (3 years) weight loss, and III) the degree of weight loss on circulating levels of adiponectin, high sensitive-C reactive protein (hs-CRP), and fibrinogen in obese subjects. Moreover, to evaluate the effect of the lipase inhibitor, orlistat, on these parameters. DESIGN Weight loss induced in 93 obese subjects (mean weight: 108.9+/-15.8 kg) through 8-week very-low-energy diet (VLED, 800 kcal/day) followed by randomization to orlistat or placebo together with lifestyle intervention for further 3 years. Adiponectin and hs-CRP were measured at baseline, after 8 weeks of VLED and 6, 12, and 36 months after the VLED by flowmetric xMAP technology (Luminex Multi-Analyte Profiling System, Luminex Corp., Austin, TX, USA). Fibrinogen was measured in a coagulation assay. RESULTS Weight loss after VLED treatment was 14.3+/-4.5 kg and after 3 years 7.7+/-8.7 kg. Orlistat-treated subjects regained 3.9 kg less than placebo-treated from the end of the VLED to 3 years (P=0.01). No differences were detected between the two groups regarding changes in adiponectin, hs-CRP, or fibrinogen. Accordingly, the groups were combined for further analyses. Serum adiponectin increased by 22% (P<0.05) after the VLED but returned to baseline after 3 years. Both short- and long-term weight losses needed to be in excess of 10% (approximately 12 kg) in order to increase adiponectin levels significantly. Weight loss was associated with a significant decrease in hs-CRP. Fibrinogen decreased by 12% (P<0.05) after 3 years. CONCLUSIONS In obese subjects, weight loss was associated with an increase in serum adiponectin and a decrease in hs-CRP and plasma fibrinogen. Long-term weight loss (3 years) must exceed 10% to induce a combined significant improvement in these inflammatory markers.
Radiographic measurement of alveolar bone loss in the living rat.

We describe a method which allows longitudinal measurements of alveolar bone loss in the living rat. The anesthetized animal is kept in a fixed and reproducible position and radiographs of an upper molar arch are taken with a mammography. In a preliminary study, 4 rats were repeatedly radiographed. In the main study, 10 rats were radiographed at day 0 and after 63 days of diet known to cause periodontitis. The radiographs were enlarged and the amount of bone lost calculated by comparing the weights of the interdental areas reproduced on standard paper. In the preliminary study, the coefficient of variation (C.V.) of the average weights of paper were fairly low (4 to 9%) in the first 3 rats, and amounted to 17% in the fourth. A statistically significant average loss of bone (16%) was found in the 10 rats in the main study when comparing the weights of papers at days 0 and 63.
Total Hemoglobin Mass, Aerobic Capacity, and HBB Gene in Polish Road Cyclists

Abstract Malczewska-Lenczowska, J, Orysiak, J, Majorczyk, E, Zdanowicz, R, Szczepańska, B, Starczewski, M, Kaczmarski, J, Dybek, T, Pokrywka, A, Ahmetov, II, and Sitkowski, D. Total hemoglobin mass, aerobic capacity, and the HBB gene in polish road cyclists. J Strength Cond Res 30(12): 3512–3519, 2016—The relationship between genes, amount of hemoglobin, and physical performance are still not clearly defined. The aim of this study was to examine the association between-551C/T and intron 2, +16 C/G polymorphisms in the beta hemoglobin (HBB) gene and total hemoglobin mass (tHbmass) and aerobic capacity in endurance athletes. Total hemoglobin mass and aerobic capacity indices, i.e.,V[Combining Dot Above]O2max, oxygen uptake at anaerobic threshold (V[Combining Dot Above]O2AT), maximal power output (Pmax), and power at anaerobic threshold (PAT) were determined in 89 young road cyclists, female (n = 39) and male (n = 50), who were genotyped for 2 polymorphisms in the HBB gene. The relative values of aerobic capacity indices differed significantly among intron 2, +16 C/G polymorphisms of the HBB gene only in female cyclists; athletes with GG genotype had significantly higher values of V[Combining Dot Above]O2max (p = 0.003), V[Combining Dot Above]O2AT (p = 0.007), PAT (p = 0.015), and Pmax (p = 0.004) than C carriers. No relationships were found between the C-carrier model (CC + CG vs. GG in the case of intron 2, +16 C/G and CC + CT vs. TT for -551 C/T polymorphisms of the HBB gene) and relative values of tHbmass. Our results demonstrated that the HBB gene could be related to aerobic capacity, but it seems that it does not result from an increase in the amount of hemoglobin in the blood.
Assessment of child-specific aerobic fitness and anaerobic capacity by the use of the power-time relationships constants.

This study first aimed to compare critical power (CP) and anaerobic work capacity (AWC), to laboratory standard evaluation methods such as maximal oxygen uptake (VO(2)max) and maximal accumulated oxygen deficit (MAOD). Secondly, this study compared child and adult CP and AWC values. Subjects performed a maximal graded test to determine VO(2)max and maximal aerobic power (MAP); and four constant load exercises. In children, CP (W * kg(-1)) was related to VO(2)max (ml * kg(-1) * min(-1); r = . 68; p = . 004). AWC (J * kg(-1) in children was related to MAOD (r = .58; p = .018). Children presented lower AWC (J * kg(-1); p = . 001) than adults, but similar CP (%MAP) values. CP (%MAP and W * kg(-1) and AWC (J * kg(-1) were significantly related to laboratory standard evaluation methods but low correlation indicated that they cannot be used interchangeably. CP (%MAP) was similar in children and adults, but AWC (J * kg(-1) was significantly lower in children. These conclusions support existing knowledge related to child-adults characteristics.
Rad3ATR Decorates Critical Chromosomal Domains with γH2A to Protect Genome Integrity during S-Phase in Fission Yeast

Schizosaccharomyces pombe Rad3 checkpoint kinase and its human ortholog ATR are essential for maintaining genome integrity in cells treated with genotoxins that damage DNA or arrest replication forks. Rad3 and ATR also function during unperturbed growth, although the events triggering their activation and their critical functions are largely unknown. Here, we use ChIP-on-chip analysis to map genomic loci decorated by phosphorylated histone H2A (γH2A), a Rad3 substrate that establishes a chromatin-based recruitment platform for Crb2 and Brc1 DNA repair/checkpoint proteins. Unexpectedly, γH2A marks a diverse array of genomic features during S-phase, including natural replication fork barriers and a fork breakage site, retrotransposons, heterochromatin in the centromeres and telomeres, and ribosomal RNA (rDNA) repeats. γH2A formation at the centromeres and telomeres is associated with heterochromatin establishment by Clr4 histone methyltransferase. We show that γH2A domains recruit Brc1, a factor involved in repair of damaged replication forks. Brc1 C-terminal BRCT domain binding to γH2A is crucial in the absence of Rqh1Sgs1, a RecQ DNA helicase required for rDNA maintenance whose human homologs are mutated in patients with Werner, Bloom, and Rothmund–Thomson syndromes that are characterized by cancer-predisposition or accelerated aging. We conclude that Rad3 phosphorylates histone H2A to mobilize Brc1 to critical genomic domains during S-phase, and this pathway functions in parallel with Rqh1 DNA helicase in maintaining genome integrity.