Miracle-dz/UniFAR-FTUs huggingface dataset:
p53 Status predicts survival in breast cancer patients treated with or without postoperative radiotherapy: a novel hypothesis based on clinical findings.

PURPOSE AND METHODS Primary breast cancer tumors without axillary metastases from 206 consecutive patients in a population-based cohort were investigated with regard to the presence of an intact p53 gene using a cDNA-based sequencing method. Clinical follow-up data and outcome of node-negative patients without any adjuvant systemic therapy (n = 168) were related to locoregional radiotherapy and p53 status. RESULTS Mutations in p53 occurred in 31 node-negative breast cancer patients who did not receive any systemic adjuvant treatment, but were treated with postoperative locoregional radiotherapy or nothing. Node-negative breast cancer patients with p53 mutations had significantly improved relapse-free survival (P = .0007), breast cancer-corrected survival (P = .01), and overall survival (P = .02) rates when treated with locoregional radiotherapy. In node-negative breast cancer patients with wild-type p53, there was no statistically significant difference in outcome between patients who received locoregional radiotherapy and those who did not. Cox proportional hazards models indicate that mutant p53 is associated with worse prognosis independent of response to radiotherapy and that response to radiotherapy is qualitatively different in tumors with p53 mutations compared with those with wild-type p53. CONCLUSION Our clinical findings define a group of breast cancer patients in whom locoregional radiotherapy improves relapse-free, breast cancer-corrected, and overall survival. The outcome for irradiated node-negative breast cancer patients with p53 alterations indicates that irradiation can induce cell death even in the presence of p53 mutations.
The thermodynamic approach to multifractal analysis

Abstract Most results in multifractal analysis are obtained using either a thermodynamic approach based on the existence and uniqueness of equilibrium states or an orbit-gluing approach based on some version of the specification property. A general framework incorporating the most important multifractal spectra was introduced by Barreira and Saussol, who used the thermodynamic approach to establish the multifractal formalism in the uniformly hyperbolic setting, unifying many existing results. We extend this framework to apply to a broad class of non-uniformly hyperbolic systems, including examples with phase transitions, and obtain new results for a number of examples that have already been studied using the orbit-gluing approach. We compare the thermodynamic and orbit-gluing approaches and give a survey of many of the multifractal results in the literature.
Vibration maps of capacitive micromachined ultrasonic transducers by laser interferometry

A 1.8-mm /spl times/ 1.8-mm capacitive micromachined ultrasonic transducer (CMUT) element is experimentally characterized by means of optical measurements. Optical displacement measurements provide information on the resonant behavior of the single membranes and also allow us to investigate the dispersion in the frequency spectrum of adjacent membranes. In addition, higher order mode shapes are observed, showing that either symmetrical or asymmetrical modes are excited in CMUT membranes. Laser interferometry vibration maps, combined with quantitative displacement measurements, provide information about the quality and repeatability of the fabrication process, which is a basic requirement for 2D array fabrication for ultrasound imaging.
A particle swarm optimization for the dynamic vehicle routing problem

Various versions of the Vehicle Routing Problem (VRP) have been studied for many years. VRP is a static problem, while in the real world, many problems have dynamic nature. In the Dynamic VRP (DVRP), not all information about the problem is known at the beginning of the planning horizon, and, in most cases the information can change after the solution process begins. This two characteristics make the DVRP harder than static VRP. In this study the DVRP is examined and a Particle Swarm Optimization algorithm is proposed. The most known benchmarks are solved with the proposed algorithm and the results are compared with the previous employed methods in the literature.
EVALUATION OF THE SOCKET SHIELD TECHNIQUE FOR IMMEDIATE IMPLANTATION

INTRODUCTION: Numerous publications have verified that tooth extraction is followed by dimensional changes of the alveolar ridge contour. The resorption of the alveolar ridge is more pronounced on the buccal than on the lingual aspect of the extraction socket. In particular, in the aesthetic zone, the successive soft and hard tissue deficiencies can interfere with optimal implant positioning and hamper the overall aesthetic outcome of implant-supported prostheses. OBJECTIVES: This study was designed to evaluate the socket shield technique clinically and radiographically as a new modality for immediate implantation in comparison to the conventional technique. MATERIALS AND METHODS: twenty patients were included in this study (n=20). They were divided in two groups; group I: Ten maxillary single rooted teeth were extracted followed by immediate implant placement using the socket shield technique. Group II: Ten maxillary single rooted teeth were extracted followed by immediate implant placement using the conventional technique. All implants were evaluated clinically and radiographically to evaluate bone loss on intervals of 1, 4 and 7 months. RESULTS: the mean horizontal and vertical bone loss value in socket shield technique group was 0.09±0.03mm & 0.43±0.23mm contrary to the conventional implantation after 7 months follow up, which was 0.33±0.14mm & 1.56±0.77mm which was statistically significant. CONCLUSIONS: The socket shield technique was beneficial in preserving the buccal bone plate
Aperiodic autocorrelation and crosscorrelation of polyphase sequences

A detailed analysis of the maximum aperiodic autocorrelation of the original Chu sequences (equivalently, P3/P4 pulse compression codes) is presented. The result implies the best known upper bound on the minimax aperiodic autocorrelation for polyphase sequences except when the length is very small or a perfect square. It is well known that determining the minimax aperiodic correlation for polyphase sequence sets is an intractable task. The simplest nontrivial cases for Barker and general polyphase sequences are solved for the first time.
Factors influencing the effect of age on prognosis in breast cancer: population based study

Abstract Objective To investigate whether young age at diagnosis is a negative prognostic factor in primary breast cancer and how stage of disease at diagnosis and treatment influences such an association. Design: Retrospective cohort study based on a population based database of patients with breast cancer containing detailed information on tumour characteristics, treatment regimens, and survival. Setting: Denmark. Subjects: 10 356 women with primary breast cancer who were less than 50 years old at diagnosis. Main outcome measures: Relative risk of dying within the first 10 years after diagnosis according to age at diagnosis after adjustment for known prognostic factors and expected mortality. Results: Overall, young women with low risk disease who did not receive adjuvant treatment had a significantly increased risk of dying; risk increased with decreasing age at diagnosis (adjusted relative risk: 45-49 years (reference): 1; 40-44 years: 1.12 (95% confidence interval 0.89 to 1.40); 35-39 years: 1.40 (1.10 to 1.78); <35 years: 2.18 (1.64 to 2.89). However, no similar trend was seen in patients who received adjuvant cytotoxic treatment. The increased risk in younger women who did not receive adjuvant treatment compared with those who did remained when women were grouped according to presence of node negative disease and by tumour size. Conclusion The negative prognostic effect of young age is almost exclusively seen in women diagnosed with low risk disease who did not receive adjuvant cytotoxic treatment. These results suggest that young women with breast cancer, on the basis of age alone, should be regarded as high risk patients and be given adjuvant cytotoxic treatment.
Oestrous behaviour of the ewe and the influence of treatment with progestagen.

Polled Dorset Horn ewes at a progestagen-synchronized oestrus (six ewes) or at a normal oestrus (six ewes) were teased for a 10-min period at 4-hr intervals by a series of different rams. The frequency of nudging, kicking, Flehmen posture, mounting and service by the ram, and of squatting, active soliciting, tail fanning and looking over shoulders by the ewe were recorded. The mean duration of oestrus\m=+-\S.E. was 48\m=. \0\m=+-\2\m=. \1hr for the ewes at a normal oestrus and 51\m=. \3\m=+-\3\m=. \5hr for ewes at a progestagen-synchronized oestrus. In the 24-hr period before the onset of oestrus, the frequencies of nudging, Flehmen and squatting were greater when the ewes were treated with progestagen. During oestrus, progestagen treatment produced no major differences in the manifestation of behaviour and some components were of a consistent pattern. At the second of five proportionately equal stages of oestrus, there was a reduction in nudging, Flehmen and squatting which corresponded to an increase in the frequency of tail fanning, looking
Performance Evaluation Internet Protocol Television (IPTV) by taking Various Modulation Schemes

IEEE describes various modulation mechanisms for WiMAX i.e. QPSK, BPSK, 16 QAM and 64 QAM. This paper measures the performance of Internet Protocol Television (IPTV) over Fixed WiMAX system taking various combinations of digital modulation. The performance is analyzed considering a number of main system parameters which involve the variation in the path-loss, video coding, scheduling service classes, various rated codes in FEC channel coding. The performance evaluation was carried out by utilizing OPNET simulator. The performance is measured with respect of packet jitter delay, packet lost, network throughput and end-to-end delay. Simulation results indicate that higher order modulation and coding techniques (namely, 16 QAM and 64 QAM) have better performance as compared to QPSK.
On Using the Bootstrap for Multiple Comparisons

There are many ways to bootstrap data for multiple comparisons procedures. Methods described here include (i) bootstrap (parametric and nonparametric) as a generalization of classical normal-based MaxT methods, (ii) bootstrap as an approximation to exact permutation methods, (iii) bootstrap as a generator of realistic null data sets, and (iv) bootstrap as a generator of realistic non-null data sets. Resampling of MinP versus MaxT is discussed, and the use of the bootstrap for closed testing is also presented. Applications to biopharmaceutical statistics are given.
Evidence to support that adventitial cysts, analogous to intraneural ganglion cysts, are also joint‐connected

Cystic adventitial disease (CAD) is a rare condition in which cyst is found within a vessel, typically producing symptoms of vascular compromise. Most commonly located in the popliteal artery near the knee, it has been reported in arteries and veins throughout the body. Its pathogenesis has been poorly understood and various surgical approaches have been recommended. We extrapolated some recent information about a similar condition, intraneural ganglion cyst affecting the deep fibular (peroneal) nerve, to the prototype, CAD of the popliteal artery. In intraneural ganglion cysts affecting the deep fibular nerve we have shown that an articular (neural) branch is the conduit between the superior tibiofibular joint and the main parent nerve for which epineurial dissection of joint fluid can occur. We hypothesized that the same principles would apply to CAD and that an articular (vascular) branch would be the conduit from the knee joint leading to dissection to the main parent vessel. We reviewed five patients with CAD of the popliteal artery in whom MRIs were available: two treated by the primary author well familiar with the proposed articular theory, and three treated by others at our institution, less familiar with it. We then reviewed the literature critically to assess for additional evidence to support our articular (synovial) theory and an anatomic explanation. In the two cases treated by the primary author a joint connection was identified on high resolution MRI prospectively and intraoperatively through the middle genicular artery (MGA); postoperatively in these cases there was no recurrence. In the other three cases, a joint connection was not identified on imaging or at operation. Reinterpretation of these cases revealed a joint connection through the MGA in the one patient who had preoperative imaging and subclinical persistence/recurrence in the two patients who underwent postoperative MRIs done for other reasons. Our review of the literature and imaging studies revealed unrecognized joint connections in CAD to the knee and other joints as well as evidence that the MGA is the conduit in cases of CAD of the popliteal artery. We believe that adventitial cysts originate in neighboring joints and dissect within articular (vascular) branches. In our opinion, the unifying articular theory and the principles introduced for intraneural ganglion cysts apply equally to common and rare sites of adventitial cysts. Clin. Anat. , 2013. © 2012 Wiley Periodicals, Inc.
Molecular cloning of two linked loci that increase the transformability of transformation-deficient mutants of Haemophilus influenzae

A plasmid containing a 13.3-kb insert (pER194) was isolated from an EcoRI genomic library of Haemophilus influenzae on the basis of its ability to increase the transformability of the transformation-deficient mutants Com-78 and Com-101. The plasmid failed to increase the transformability of the Rec-1 and Rec-2 mutants, indicating that the mutations producing the Com-78 and Com-101 phenotypes are distinct from those giving rise to the Rec-1 and Rec-2 phenotypes. The physical mapping of the cloned fragment on the H. influenzae chromosome was found to be consistent with the genetic mapping of the Com-101 trait. A 2.8-kb EcoRI-BglII subfragment, representing one end of the 13.3-kb clone, was found to increase the transformation frequency of the Com-78 and Com-101 mutants when supplied in trans, indicating that the subfragment carries one or more loci required for chromosomal transformation. The corresponding region of the Com-101 chromosome was determined by hybridization analysis to contain a 0.3-kb insertion, suggesting that the Com-101 strain may contain an insertion mutation at this locus. A 3.0-kb EcoRI-MluI subfragment, representing the other end of the 13.3-kb EcoRI fragment, was found to increase the transformation frequency of the Com-101 mutant but not of the Com-78 mutant, suggesting that the Com-101 phenotype results from a complex genotype involving mutations at two or more transformation-related loci. This conclusion is consistent with data indicating that the Com-101 trait can be genetically separated into at least two components.
Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study.

BACKGROUND The long-term role of fatty acids (FAs) in the cause of diabetes remains largely unclear. OBJECTIVE We aimed to investigate erythrocyte membrane FAs, desaturase activity, and dietary FAs in relation to the incidence of type 2 diabetes. DESIGN We applied a nested case-cohort design (n = 2724, including 673 incident diabetes cases) within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study, which involves 27,548 middle-aged subjects. Thirty erythrocyte membrane FAs (percentage of total FAs) and FA intake (percentage of total fat) were measured at baseline, and physician-confirmed incident diabetes was assessed during a mean follow-up of 7.0 y. We evaluated Δ⁵ desaturase (D5D) and Δ⁶ desaturase (D6D) activity by using FA product-to-precursor ratios (traditional approach) and by investigating variants in FADS1 and FADS2 genes that encode these desaturases (Mendelian randomization approach). RESULTS As a main finding, erythrocyte 16:1n-7 and 18:3n-6 and FA ratios, which reflect stearoyl coenzyme A desaturase (SCD) and D6D activity, were directly related to diabetes risk in multivariable-adjusted models [relative risks (95% CIs) comparing extreme quintiles: 16:1n-7, 2.11 (1.46, 3.05); 18:3n-6, 2.00 (1.38, 2.88); SCD, 2.61 (1.75, 3.89); and D6D, 2.46 (1.67, 3.63)], whereas the FA ratio that reflects D5D activity was inversely associated with risk [0.46 (0.31, 0.70)]. The Mendelian randomization approach corroborated the direct relation for D6D activity and tended to support the inverse relation for D5D activity. Proportions of dietary FAs showed only modest to low correlations with erythrocyte FAs and were not significantly associated with risk. CONCLUSION The FA profile of erythrocyte membrane phospholipids and activity of desaturase enzymes are strongly linked to the incidence of type 2 diabetes.
ZnO/Ag nanoarrays substrate for surface-enhanced Raman scattering (SERS) detection

ZnO/Ag composite nanoarrays structure have been successfully prepared through a very simple deposition method. The adherence of Ag nanoparticles to ZnO nanoarrays was realized through the deposition under normal temperature. Due to their exceptional properties, these composite nanoarrays were used as substrate in surface-enhanced Raman scattering (SERS) measurement. SERS signals of typical analytes such as Rhodamine 6G (R6G) were observed from the ZnO/Ag composite nanoarrays, which the results shows that the SERS signals can be detected when the concentration of R6G was 1×10-9 M. This work provides a new method to prepare SERS substrates for SERS detection.
Gender differences in the maintenance of response to cognitive behavior therapy for posttraumatic stress disorder.

OBJECTIVE To examine potential differential responses in men and women to cognitive behavior therapy for posttraumatic stress disorder (PTSD). METHOD Fifty-two men and 56 women diagnosed with PTSD participated in randomized controlled trials of cognitive behavior therapy for PTSD. Participants were randomly allocated to either (a) exposure-only therapy (Ex) or (b) exposure-based treatment combined with cognitive restructuring (ExCR). RESULTS There were no significant differences between men and women in treatment response immediately after treatment in either Ex or ExCR. At 6-month follow-up, men displayed significantly more severe PTSD symptoms in the Ex group compared with women in the Ex group, and compared with men and women in the ExCR conditions. CONCLUSIONS These findings suggest that men with PTSD have a reduced maintenance of treatment gains following exposure therapy compared with women, but display less relapse if exposure therapy is combined with cognitive therapy. These findings are consistent with evidence that women recall emotional memories and retain extinction memories more strongly than men, which may facilitate emotional processing and long-term treatment gains.
pH‐Controlled Delivery of Nanoparticles into Tumor Cells

Nanoparticles target tumor cells by pH-controlled means. Nanoparticles carry three synergistic delivery functions: 1) tumor tissue targeting by the EPR effect; 2) tumor cell targeting by pHLIP-mediated membrane-localization; and 3) tumor cell uptake by adsorptive-mediated endocytosis.
Modeling of Electron Mobility in Strained Si Devices

A model describing the anisotropic electron mobility in strained Si has been developed. Our analytical model includes the effect of strain-induced splitting of the conduction band valleys in Si, inter-valley scattering, and doping dependence. Monte Carlo simulations were performed to verify the results for the complete range of Ge contents and for a general orientation of the SiGe buffer. Our mobility model is suitable for implementation into a conventional TCAD simulation tool. Keywords—strained Si, SiGe, mobility model, inter-valley scattering, Technology CAD, Monte Carlo simulations
Analysis of large scale PV penetration impact on IEEE 39-Bus power system

The integration of Renewable energy sources (RES) into the traditional electric grid infrastructure is a challenging task due to their intermittent nature as well as the technical and non-technical complexities. This paper presents the impacts of large scale Photovoltaic (PV) penetration into the IEEE 39-bus test system. The modeled PV plants are integrated at suitable locations to study the impacts of penetration using Siemens PSS/E (Power System Simulator for Engineers) software. The maximum PV integration capacity is determined based on the variation in slack bus generation with gradual increment in penetration levels. Furthermore, the simulations are carried to study the effect of sudden loss of PV plants, three phase faults at solar PV plant connected bus for different PV penetration levels. The simulation results of PV integration reveal that the dynamic response of PV plants aids to meet the peak demands to enhance the reliability of smart electric grids.
A New Species of Spauligodon (Nematoda: Oxyurida: Pharyngodonidae) in Geckos from São Nicolau Island (Cape Verde) and Its Phylogenetic Assessment

abstract: A new nematode species, Spauligodon nicolauensis n. sp. , is described from geckos Tarentola bocagei and Tarentola nicolauensis on the island of São Nicolau, Cape Verde. The new nematode was found in the pellets obtained directly from the geckos in a non-invasive fashion, and its identity was assessed both at morphologic and genetic levels. The new species has morphological similarities with Spauligodon tarentolae Spaul, 1926, also parasitizing geckos from the Canary Islands. However, the male cloacal region in the new species is distinct, presenting a different shape of the caudal papillae. The overall resemblance probably resulted from colonization via descent from an ancestor of S. tarentolae carried by the ancestor of Cape Verde Tarentola. The analysis of nuclear DNA sequences confirms that the new species is phylogenetically distinct from all other Spauligodon species already analyzed, forming a group clearly separated from species parasitizing lacertid lizards. The COI genetic distance suggests that the S. nicolauensis n. sp. found in the 2 species of geckos in São Nicolau Island may have resulted from a host-switching event, when they came into contact after the unification of the island.
Modeling and compensation for hysteresis properties in piezoelectric actuators

This paper presents a modeling and compensation approach for hysteresis properties in piezoelectric actuators. Nonlinearities due to the hysteresis and creep phenomena inherently exist in the piezoelectric actuator, resulting in the low control performance in positioning and/or tracking accuracy. In this paper, at first, the hysteresis property is mathematically modeled by Prandtl-Ishlinskii model. Based on the mathematical hysteresis model, an inverse model-based compensator combined with linear feedback controller is applied to compensate for the nonlinearities in piezoelectric actuator. The proposed approach has been evaluated by experiments using a piezo-actuated stage.
Point‐of‐Care Testing for Diabetes

Point-of-care testing, or near patient testing, refers to testing of biochemical parameters with devices that provide rapid results so the data can be immediately used in clinical care. Because the diagnosis and, in particular, management, of diabetes mellitus is largely relegated to the outpatient setting (including self-care in the home, school and workplace), point-of-care testing is particularly relevant for this disease. Moreover, the need for timely (immediate) results for glucose monitoring makes point-of-care testing necessary for the management of diabetes in the inpatient and outpatient setting. The following review examines the role of various assays in the diagnosis and management of diabetes and discusses the role of point-of-care testing.