Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive functioning and cortisol suppression in recurrent major depression.

Major Depressive Disorder (MDD) is often associated with high levels of stress and disturbances in the hypothalamic-pituitary-adrenal (HPA) system, yielding high levels of cortisol in addition to cognitive dysfunction. The aim of the present study was to examine the relation between cortisol levels after the dexamethasone suppression test and cognitive function in recurrent unipolar MDD patients. Twenty-four patients meeting the Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.) criteria for a recurrent MDD diagnosis were included in the study. The control group was matched for age, sex, and education level. Cortisol was measured in saliva collected with Salivette sampling devices. Saliva samples were collected four times during a 24-hr period over two consecutive days: at awakening, after 45 min, after 7 hr, and at 11:00 p.m. One milligram of dexamethasone was given on Day 1 at 11:00 p.m. The neuropsychological test battery consisted of standardized tests measuring cognitive functioning within verbal and visual memory, as well as executive functioning. Cortisol levels did not differ between patients and controls on Day 1. Cortisol levels in patients were higher than in controls at awakening on Day 2 (D2S1), after dexamethasone administration the previous evening. All significant correlations between cognitive measures and cortisol at D2S1 were negative, indicating that low suppression after intake of dexamethasone is related to poor cognitive functioning. Significant relations were found in three of the cognitive tests measuring verbal memory, semantic fluency, and inhibition. The present findings indicate that dysregulation of the HPA-axis is related to poor verbal memory functioning. There was no firm evidence that abnormal cortisol levels were associated with inhibition difficulties.
Deep Learning from EEG Reports for Inferring Underspecified Information

Secondary use1of electronic health records (EHRs) often relies on the ability to automatically identify and extract information from EHRs. Unfortunately, EHRs are known to suffer from a variety of idiosyncrasies – most prevalently, they have been shown to often omit or underspecify information. Adapting traditional machine learning methods for inferring underspecified information relies on manually specifying features characterizing the specific information to recover (e.g. particular findings, test results, or physician’s impressions). By contrast, in this paper, we present a method for jointly (1) automatically extracting word- and report-level features and (2) inferring underspecified information from EHRs. Our approach accomplishes these two tasks jointly by combining recent advances in deep neural learning with access to textual data in electroencephalogram (EEG) reports. We evaluate the performance of our model on the problem of inferring the neurologist’s over-all impression (normal or abnormal) from electroencephalogram (EEG) reports and report an accuracy of 91.4% precision of 94.4% recall of 91.2% and F1 measure of 92.8% (a 40% improvement over the performance obtained using Doc2Vec). These promising results demonstrate the power of our approach, while error analysis reveals remaining obstacles as well as areas for future improvement.
Lymphoepithelial Cyst of Parotid in an Immunocompetent Patient with Chronic Otitis Media

Lymphoepithelial cysts of parotid are known to occur in HIV patients. In the present report, lymphoepithelial cyst of parotid was diagnosed in a middle aged immunocompetent patient, along with chronic otitis media. The source of infection and treatment options are summarized.
High performance transmission using differential multi-pulse modulation in transmit-reference ultra-wideband (TR-UWB) communications

Transmit reference ultra wideband (TR-UWB) communication system is gaining increased popularity as a prospective transmission scheme for short-range high data rate indoor wireless communication because of its simplification of synchronization and channel estimation that are known to be difficult problems in UWB communication systems. However, TR-UWB has problem that the data rate will be degraded when using the pulse-pair for transmitted one data bit. In this paper, a combined Pulse Position modulation (PPM), Differential BPSK and Multi-Pulse Modulation (MPM) have been proposed in order to increase the total data rate using the same number of pulses. By the these schemes, the modulated pulse that has ever been used for transmitted only one data bit in each pulse-pair in conventional TR-UWB system, can be used for transmitted more than one bit data depending on the level of MPM and PPM modulation. Moreover, the error performance has been upgraded by these modulation schemes as shown in the later section. In addition, the simulation results show that the total throughput performance of the proposed system has been improved, nearly 4-5 times when comparing with the conventional TR-UWB communication system
Myostatin inactivation increases myotube size through regulation of translational initiation machinery

Myostatin deficiency leads in skeletal muscle overgrowth but the precise molecular mechanisms underlying this hypertrophy are not well understood. In this study, to gain insight into the role of endogenous myostatin in the translational regulation, we used an in vitro model of cultured satellite cells derived from myostatin knock‐out mice. Our results show that myostatin knock‐out myotubes are larger than control myotubes and that this phenotype is associated with an increased activation of the Akt/mTOR signaling pathway, a known regulator of muscle hypertrophy. These results demonstrate that hypertrophy due to myostatin deficiency is preserved in vitro and suggest that myostatin deletion results in an increased protein synthesis. Accordingly, the rates of global RNA content, polysome formation and protein synthesis are all increased in myostatin‐deficient myotubes while they are counteracted by the addition of recombinant myostatin. We furthermore demonstrated that genetic deletion of myostatin stimulates cap‐dependent translation by positively regulating assembly of the translation preinitiation complex. Together the data indicate that myostatin controls muscle hypertrophy in part by regulating protein synthesis initiation rates, that is, translational efficiency. J. Cell. Biochem. 112: 3531–3542, 2011. © 2011 Wiley Periodicals, Inc.
Posttraumatic Intracortical Lytic Lesion in a 46-Year-Old Woman

A 46-year-old woman without significant medical and family histories presented with a 20-day history of pain in the anterior left leg and ankle. She reported a direct trauma in the same tibia 2 months previously. Since then, the pain was decreasing gradually until it began insidiously increasing in the past 20 days. Physical examination revealed an increased local temperature. There was no increase of the leg’s diameter compared with the contralateral leg, no palpable soft tissues mass, and there were no inguinal adenopathies. Gait and motor strength, distal pulses, and sensation were normal. Laboratory findings were normal, with no increase of ESR and PCR. The referring physician took plain radiographs and CT scans. A MRI scan and a bone scan of the extremity were obtained (Figs 1–4). Based on the history, physical findings, and imaging studies, what is the differential diagnosis? From the *Consultor, Orthopaedic Surgery, †Resident in Orthopaedic Surgery, Department of Orthopedic Surgery, Muskuloskeletal Oncology Unit, Institut Clínic de l’Aparell Locomotor, Hospital Clínic Universitari de Barcelona, School of Medicine, Barcelona, Spain; and the ‡Senior Specialist in Orthopaedic Surgery, Department of Pathology, Muskuloskeletal Oncology Unit, Institut Clínic de l’Aparell Locomotor, Hospital Clínic Universitari de Barcelona, School of Medicine, Barcelona, Spain. The authors have disclosed that they have no financial interests in or relationships with any commercial companies pertaining to this educational activity. These materials are available on CORRONLINE for continuing medical education credit. Correspondence to: Andrés Combalia-Aleu, MD, Institut Clínic de l’Aparell Locomotor, Hospital Clínic Universitari, Villarroel 170, 08036 Barcelona, Spain (e-mail: combalia @ clinic.ub.es). DOI: 10.1097/01.blo. 0000127814.91541. 5b CLINICAL ORTHOPAEDICS AND RELATED RESEARCH Number 427, pp. 266–271 © 2004 Lippincott Williams & Wilkins
Radiographic visceral patterns in the asplenia syndrome.

Abstract The postero-anterior chest and abdominal radiographs of 32 patients were evaluated; in each the asplenia syndrome had been proved at autopsy. Three basic visceral patterns are described: situs solitus, situs inversus, and situs ambiguus. The cardiovascular manifestations of symmetry are diagnosed only by angiocardiography or at necropsy. In any patient with heterotaxia and congenital heart disease or in any patient with complex congenital heart disease, special attention should be paid to the major bronchial anatomy. Because of the severe associated congenital cardiac lesions, a diagnosis of the congenital asplenia syndrome implies a poor prognosis.
Perineal Gas Gangrene: Two Cases Report and Review of the Literature

A 57 –year-old male presented to the emergency department reporting three days of wor‐ sening perineal and scrotal pain and swelling. He denied diabetes or trauma. His genitouri‐ nary examination revealed a draining lesion in his left inguinal region with surrounding indurations and cellulites extending onto his scrotum. His perineum was edematous and tender with a distinct region of ecchymosis and crepitus. The patient’s blood pressure was 100/56 mmhg; his body temperature rose to 39°C. The laboratory data demonstrated severe infection with white blood cell count of 27000/mm3, a C-reactive protein level of 158mg/dl and a blood sugar level of 14,09mmom/L. Computed tomography showed a perineal collec‐ tion extended to the left ischio rectal region with emphysematous gangrene extended to the
Preprocessing in Propositional Satisfiability Using Bounded (2, k)-Consistency on Regions with a Locally Difficult Constraint Setup

A new type of partially global consistency derived from (2, k)-consistency called bounded (2, k)- consistency (B2C-consistency) is presented in this paper. It is designed for application in propositional satisfiability (SAT) as a building block for a preprocessing tool. Together with the new B2C-consistency a special mechanism for selecting regions of the input SAT instance with difficult constraint setup was also proposed. This mechanism is used to select suitable difficult sub-problems whose simplification through consistency can lead to a significant reduction in the effort needed to solve the instance. A new prototype preprocessing tool preprocessSIGMA which is based on the proposed techniques was implemented. As a proof of new concepts a competitive experimental evaluation on a set of relatively difficult SAT instances was conducted. It showed that our prototype preprocessor is competitive with respect to the existent preprocessing tools LiVer, NiVer, HyPre, blocked clause elimination (BCE), and Shatter with saucy 3.0.
A Novel Miniaturized Dual-Layered LTE Printed Antenna for Handheld Devices

In this letter, a novel miniaturized multilayer internally printed antenna combined with two FR4 materials for triple Long Term Evolution (LTE) band operation is proposed. The proposed antenna is designed using a capacitive feed structure and an orthogonal meander line at the top edge of a subsection of the complete structure with dimensions of only 14 × 15 × 3.2 mm3. This covers triple-band operation (LTE700, LTE2300, and LTE2500). The complete dimensions of the mobile device are 50 × 100 mm2. The reflection coefficient is measured and used to demonstrate that the operation bandwidth is 42 MHz in LTE700 operation by a 3:1 VSWR. It is also suited to two full-band operations (LTE2300 and LTE2500) by using the definition of the -10-dB reflection coefficient in two higher modes of operation.
The submental island flap in lingual cancer reconstruction

Purpose: Large defects resulting from surgical excision of oral cancer require various kinds of flap to reconstruct the defect. Therefore the aim of this study is to assess the application potentials of submental island flap in lingual cancer. Methods: Over the 3 years, submental island flap has been studied in a 13 cases of lingual cancer patients and follow-up was accordingly done. The sites, stage of tumor, pattern of neck dissection, technique of flap transfer as well as postoperative complications were recorded. Results: The submental island flap was used for reconstruction after lingual cancer ablation in 13 patients in our department (9 men and 4 women) from 2013 to 2015. The average age of the patients was 50.8 years (range 37 to 69 years). The follow-up period ranged from 5 to 24 months. Size of the skin paddle ranged for 5.5×4 cm to 8×4 cm. There were no cases of marginal mandible nerve palsy. In all cases, good skin color and texture match were achieved. Not any debulking of flap was found in patients. The donor site recovered well without any scar remaining and any restriction of neck movement. Conclusions: The submental island flap is an excellent alternative for reconstruction of lingual cancer defect due to its reliability, versatility, and relative ease of application. More studies will be performed to follow-up the longterm observation of the patients.
Effects of a soy-based dietary supplement compared with low-dose hormone therapy on the urogenital system: a randomized, double-blind, controlled clinical trial

ObjectiveThis study aims to compare the effects of a soy-based dietary supplement, low-dose hormone therapy (HT), and placebo on the urogenital system in postmenopausal women. MethodsIn this double-blind, randomized, placebo-controlled trial, 60 healthy postmenopausal women aged 40 to 60 years (mean time since menopause, 4.1 y) were randomized into three groups: a soy dietary supplement group (90 mg of isoflavone), a low-dose HT group (1 mg of estradiol plus 0.5 mg of norethisterone), and a placebo group. Urinary, vaginal, and sexual complaints were evaluated using the urogenital subscale of the Menopause Rating Scale. Vaginal maturation value was calculated. Transvaginal sonography was performed to evaluate endometrial thickness. Genital bleeding pattern was assessed. Statistical analysis was performed using &khgr;2 test, Fisher’s exact test, paired Student’s t test, Kruskal-Wallis test, Kruskal-Wallis nonparametric test, and analysis of variance. For intergroup comparisons, Kruskal-Wallis nonparametric test (followed by Mann-Whitney U test) was used. ResultsVaginal dryness improved significantly in the soy and HT groups (P = 0.04). Urinary and sexual symptoms did not change with treatment in the three groups. After 16 weeks of treatment, there was a significant increase in maturation value only in the HT group (P < 0.01). Vaginal pH decreased only in this group (P < 0.01). There were no statistically significant differences in endometrial thickness between the three groups, and the adverse effects evaluated were similar. ConclusionsThis study shows that a soy-based dietary supplement used for 16 weeks fails to exert estrogenic action on the urogenital tract but improves vaginal dryness.
PET and MRA findings in cluster headache and MRA in experimental pain

Background: Cluster headache (CH), like migraine, is still regarded as a vascular headache although in both conditions a CNS cause has been suggested. Objective: To examine neurovascular mechanisms in CH. Methods: The authors used functional imaging with PET to investigate 18 CH patients (25 to 62 years old). Ten were in the active period (nine patients with induced attacks and one with spontaneous attack) and eight were out of their bout. In addition, the authors studied spontaneous CH and experimental pain in volunteers using MR angiography. Results: When an acute CH attack was triggered with nitroglycerin (NTG), activation occurred in the ipsilateral posterior inferior hypothalamic gray, the contralateral ventroposterior thalamus, the anterior cingulate cortex, the ipsilateral basal ganglia, the right anterior frontal lobe, and both insulae. In patients out of the bout who experienced only a mild NTG headache, activation was seen bilaterally in the insulae and frontal cortices, the anterior cingulate cortex, the right thalamus, and the left basal ganglia, but not in the hypothalamic gray area. In addition, the authors found a significant activation (vasodilatation) in the region of the major basal arteries that was caused in part by NTG but was also observed in the spontaneous case and could be induced by capsaicin injection into the forehead. Therefore, the vasodilatation is likely to be mediated by neural mechanisms involved in the acute CH attacks that are present in every human being. Conclusions: Dilatation of cranial vessels is not specific to any particular headache syndrome but generic to cranial neurovascular activation, probably mediated by the trigeminoparasympathetic reflex. These data confirm that CH is a CNS disorder best considered as a form of neurovascular headache.
Support vector machines based on hyper-ball clustering

In this paper, in order to reduce the support vectors on a large scale data set, we train support vector machines which utilize the hyper-spheres as the training samples. By representing adjacent samples of the same class as hyper-spheres, the boundary location can be controlled both by the center and radius of the hyper-spheres. We demonstrate that the optimization problem in this condition can be solved easily only by revising initial conditions of sequential minimal optimization (SMO) algorithm. Compared with previous algorithms on several data sets, the proposed algorithm is quite competitive in both the computational efficiency and the classification accuracy.
An Augmented Nonlinear LMS for Digital Self-Interference Cancellation in Full-Duplex Direct-Conversion Transceivers

In future full-duplex communications, the cancellation of self-interference (SI) arising from hardware nonidealities will play an important role in the design of mobile-scale devices. To this end, we introduce an optimal digital SI cancellation solution for shared-antenna-based direct-conversion transceivers. To establish that the underlying widely linear signal model is not adequate for strong transmit signals, the impact of various circuit imperfections, including power amplifier distortion, frequency-dependent I/Q imbalance, quantization noise, and thermal noise, on the performance of the conventional augmented least mean square (LMS) based SI canceller, is analyzed. In order to achieve a sufficient signal-to-interference-plus-noise ratio when the nonlinear SI components are not negligible, we propose an augmented nonlinear LMS based SI canceller for a joint cancellation of both the linear and nonlinear SI components by virtue of a widely nonlinear model fit. A rigorous mean and mean square performance evaluation is conducted to justify the performance advantages of the proposed scheme over the conventional augmented LMS solution. Simulations on orthogonal frequency division multiplexing-based wireless local area network standard compliant waveforms support the analysis.
Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve‐dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012)

Recently, we have presented data supporting the notion that PIKfyve not only produces the majority of constitutive phosphatidylinositol 5‐phosphate (PtdIns5P) in mammalian cells but that it does so through direct synthesis from PtdIns. Another group, albeit obtaining similar data, suggests an alternative pathway whereby the low‐abundance PtdIns(3,5)P2 undergoes hydrolysis by unidentified 3‐phosphatases, thereby serving as a precursor for most of PtdIns5P. Here, we review the experimental evidence supporting constitutive synthesis of PtdIns5P from PtdIns by PIKfyve. We further emphasize that the experiments presented in support of the alternative pathway are also compatible with a direct mechanism for PIKfyve‐catalyzed synthesis of PtdIns5P. While agreeing with the authors that constitutive PtdIns5P could theoretically be produced from PtdIns(3,5)P2 by 3‐dephosphorylation, we argue that until direct evidence for such an alternative pathway is obtained, we should adhere to the existing experimental evidence and quantitative considerations, which favor direct PIKfyve‐catalyzed synthesis for most constitutive PtdIns5P.
SBDART : A Practical Tool for Plane-Parallel Radiative Transfer in the Earth ' s Atmosphere

SBDART (Santa Barbara DISORT Atmospheric Radiative Transfer) is a FORTRAN computer code designed for the analysis of a wide variety of radiative transfer problems encountered in satellite remote sensing and atmospheric energy budget studies. The program is based on a collection of highly developed and reliable physical models, which have been developed by the atmospheric science community over the past few decades. The following discussion is a brief introduction to the key components of the code and the models on which they are based.
Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor

The capacity of the cytokines gamma interferon (IFN-gamma), interleukin-4 (IL-4), and tumor necrosis factor (TNF) to activate tuberculostatic functions in murine bone marrow-derived macrophages (BMM phi) was investigated. In confirmation of earlier findings, IFN-gamma rendered BMM phi capable of inhibiting subsequent infection with Mycobacterium bovis. In contrast, IL-4 and TNF failed to inhibit mycobacterial growth. However, in already infected BMM phi, tuberculostasis was induced by subsequent stimulation with IL-4. Although TNF alone was ineffective, it showed synergy with IFN-gamma in the stimulation of tuberculostasis. Our data suggest that not only IFN-gamma but also IL-4 and TNF participate in the control of mycobacterial growth.