Miracle-dz/UniFAR-FTUs huggingface dataset:
Small worlds, inheritance networks and industrial clusters

ABSTRACT The performance of firms within industrial clusters has been the subject of a multitude of studies. The organizational attributes inherited by spinoffs from parent firms is one explanation behind performance premiums. This paper examines the relationship between a spinoff’s network and its geographic location in an industrial cluster. We hypothesize that there is a negative relationship between a spinoff’s network efficiency and its distance from the cluster’s centroid. Although recent literature infers that the transmission of knowledge in industrial clusters is accomplished via inherited network ties, this has not been directly measured. This paper aims to fill that research gap. We find that, after controlling for firm size, parent size and age, there is indeed a statistically significant and negative relationship between network efficiency and geographic distance to a cluster’s core.
Application of upper echelon theory for corporate social responsibility dimensions: Evidence from the restaurant industry

ABSTRACT This study applies upper echelon theory and validates its conceptual framework by investigating chief executive officers’ observable determinants (e.g., the age, tenure, and formal education of top managers) of corporate social responsibility (CSR) in the restaurant industry. Multiple CSR dimensions (e.g., operational, non-operational, community, diversity, employee, environment, and product) are examined through fixed effects regression. The results indicate that older and highly educated CEOs who serve more stakeholders perform fewer CSR activities, whereas longer tenured CEOs who serve more stakeholders perform more CSR activities. Consequently, non-operational, community-, diversity-, employee-, and environment-related CSR activities are significantly explained by the proposed attributes. By validating both the theoretical perspectives of upper echelon theory and the role of stakeholder demands in CSR decisions, this research can contribute to expanding the CSR and upper echelon literature to the restaurant industry.
Streptococcus agalactiae from pregnant women: antibiotic and heavy-metal resistance mechanisms and molecular typing

SUMMARY We investigated the antibiotic and heavy-metal resistance mechanisms, virulence genes and clonal relationships of macrolide- and/or lincosamide-resistant (M+/−LR) Streptococcus agalactiae (group B Streptococcus, GBS) isolates from pregnant women in La Rioja in Northern Spain, a region with a significant immigrant population. In total 375 GBS isolates were recovered during 2011. About three-quarters of isolates were from European nationals and the remainder distributed among 23 other nationalities. Seventy-five (20%) were classified as M+/−LR strains and 28 (37%) of these were resistant to ⩾3 classes of antibiotics. Capsular serotypes III (29·3%), V (21·3%) and II (12%) were the most frequent. A wide variety of antibiotic resistance genes were detected in M+/−LR strains; notably, 5·3% harboured the lsa(C) gene associated with cross-resistance, and tet(W) was identified in a single strain. We report, for the first time, the detection of cadmium and copper resistance encoded by tcrB + cadA + cadC genes in 20 M+/−LR strains, which raises the possibility of co-selection of antibiotic and heavy-metal resistance disseminated through mobile genetic elements. The M+/−LR strains were highly diverse by DNA macrorestriction profiles (65 patterns) and 16 multilocus sequence types (STs) distributed among six clonal complexes; the most frequent were ST1, ST19, and ST12, and two strains were novel (ST586 and ST601). In conclusion, a wide diversity of genetic lineages of macrolide, lincosamide and heavy-metal- resistant GBS strains was observed in an ethnically diverse maternal population.
Credit supply, post-acquisition performance and financial constraints

ABSTRACT We study the effect of credit supply on the acquisition behaviour of financially constrained (FC) and financially unconstrained (UC) firms. FC firms are likely to conduct acquisitions when credit supply is greater while UC firms can conduct acquisitions whenever a good opportunity arises. We argue that the flexibility unconstrained firms have is valuable. Our empirical results indicate that UC firms outperform FC firms up to 36 months after the acquisition. We also find that increased credit supply increases the probability of conducting mergers and acquisitions (M&As) for FC firms while it has less impact on M&A behaviour of UC firms.
Effects of shift length on quality of patient care and health provider outcomes: systematic review

Background: Healthcare providers work increasingly under a variety of shift work systems to cover the continuous care required by patients. However, the effects of shift work on patient and provider outcomes in healthcare settings has not been systematically evaluated. Objective: To identify and analyse the available evidence on the effect of shift length (8-h vs 12-h shifts) on quality of patient care and healthcare provider outcomes. Methods: Systematic searching of eight online databases, key governmental/organisational websites and academic journals with ancestry search of relevant articles (limited to articles published in English and Spanish). Results: Of 562 articles that were retrieved from 20 446 titles identified through database and manual searches, 27 satisfied the inclusion criteria, of which 15 were rejected because of low methodological quality. The 12 final studies included cross-sectional/survey (7), before–after (3) and prospective cohort (2) designs. The main primary outcomes evaluated were: (1) quality of patient care and (2) healthcare provider outcomes. The results were equivocal. With respect to the effect of shift length on quality of patient care, two studies found that errors and near errors were associated with working longer shifts, and another study reported decreased patient complications and length of stay with longer shifts. Specific healthcare provider outcomes such as health complaints, well-being, drug and alcohol consumption, stress and job satisfaction were mostly evaluated by single studies and therefore there was insufficient evidence from which to draw conclusions. Conclusions: Methodological quality of the studies generally was low and results equivocal with insufficient evidence to determine the effects of shift length on quality of patient care and healthcare provider outcomes. Clearly, robust well-designed studies are needed to examine the effect of shift length on patient and healthcare provider outcomes.
Occurrence of beauvericin and enniatins in wheat flour and corn grits on the Japanese market, and their co-contamination with type B trichothecene mycotoxins

ABSTRACT The contamination levels of beauvericin and four enniatins, A, A1, B and B1, in 207 samples of wheat flour and corn grits on the Japanese market were determined by an analytical method based on LC-MS/MS. The toxins were extracted from samples with acetonitrile–water (85:15, v/v) and then purified with C18 cartridges. The method was validated in a single laboratory using spiked samples at two levels; the recovery of the five toxins ranged from 91.1% to 113.8%. Enniatin B was frequently detected in imported wheat flour (81.8%) and domestic wheat flour (85.6%), and the highest concentration of enniatin B was present in a domestic wheat sample (633 μg kg−1). In corn grits, beauvericin was found in 34% of the samples, but enniatins were not detected at all. The maximum concentration of beauvericin in corn grits was 26.1 μg kg−1. Deoxynivalenol and nivalenol in the same samples were determined by a method using an immunoaffinity column. Co-contamination of deoxynivalenol and enniatins was observed in 61% of the imported wheat samples and in 58% of the domestic wheat samples. These results suggest the need for a risk assessment for cyclic depsipeptide mycotoxins in Japan and a study on the synergistic effect of deoxynivalenol and enniatins.
Aberrant DNA Methylation of P16, MGMT, and hMLH1 Genes in Combination with MTHFR C677T Genetic Polymorphism in Esophageal Squamous Cell Carcinoma

To explore the role of aberrant hypermethylation of cancer-related genes, such as P16, MGMT, and hMLH1, in the esophageal squamous cell carcinoma (ESCC) as well as its relation to dietary folate intake and MTHFR C677T polymorphism, we conducted a molecular epidemiologic study in China. One hundred and twenty-five histologically confirmed ESCC patients having undergone surgery in the Yangzhong People's Hospital between January 2005 and March 2006 were recruited. The aberrant CpG island hypermethylation of P16, MGMT, and hMLH1 genes could be found in cancer tissues with frequency of about 88.0%, 27.2%, and 3.2%, respectively, and in remote normal-appearing esophageal tissues with frequency of about 36.8%, 11.2%, and 0.0%, respectively. No hypermethylation was found in the normal esophageal tissues from healthy controls. Compared with those patients without lymph node metastasis, MGMT gene showed a higher proportion of hypermethylation in cancer tissues, whereas P16 gene showed a higher proportion of hypermethylation in remote normal-appearing esophageal tissues in patients with lymph node metastasis. A significant association was found between MTHFR C677T genetic polymorphism and CpG island methylation status of MGMT gene. After adjustment for potential confounders, individuals carrying CT or TT genotype have higher frequency of hypermethylation in MGMT gene in cancer tissues, with odds ratio of 3.34 (95% confidence interval, 1.07-10.39) and 3.83 (95% confidence interval, 1.13-12.94), respectively. This study indicated that the aberrant CpG island hypermethylation of cancer-related genes was associated with ESCC and might be a promising biomarker in diagnosis and prognosis. (Cancer Epidemiol Biomarkers Prev 2008;17(1):118–25)
Retroviral interleukin 1α gene transfer in bone marrow stromal cells in a primate model: induction of myelopoiesis stimulation

Summary. Effects of interleukin 1‐α (IL‐1α), a proinflammatory cytokine with pleiotropic activity, in the myelopoietic setting, is mainly linked to its ability to increase haematopoietic growth factor production by bone marrow stromal cells. In order to minimize systemic effects of IL‐1α therapy, we proposed a model of retroviral IL‐1α gene transfer within bone marrow stromal cells in the macaque cynomolgus. Invitro, 10–15% of bone marrow stromal cells was effectively transduced by retroviral vector (murine Moloney leukaemia virus‐derived) expressing IL‐1α/LacZ, or LacZ alone as control marker, as assessed by βGal staining. IL‐1α gene expression was upregulated [semiquantitative reverse transcription polymerase chain reaction (RT‐PCR)] within the transduced cells and the cell supernatant showed an increased production of granulocyte colony‐stimulating factor (G‐CSF) and granulocyte–macrophage (GM)‐CSF (enzyme‐linked immunosorbent assay) and an increased clonogenic activity (colony‐forming cell assay). Ex vivo autologous expanded IL‐1α/LacZ transduced bone marrow stromal cells were reinfused in two macaques (and two control animals for LacZ alone as controls), without clinical systemic toxicity; LacZ expression by RT‐PCR was detected in one animal of each group between d 4 and 9. A slight increase of the peripheral blood leucocyte counts (both polymorphonuclear cells and monocytes) of the two animals transduced with IL‐1α/LacZ was observed within 10 d, indicating stimulation of myelopoiesis.
Potential of Moringa oleifera root and Citrus sinensis fruit rind extracts in the treatment of ulcerative colitis in mice

Context: The plant Moringa oleifera Lam (Moringaceae), commonly known as the drumstick tree, is an indigenous species in India. This species has been of interest to researchers because traditionally its roots are reported in the treatment of ulcerative colitis (UC). Traditionally it is reported that Citrus sinensis Linn (Rutaceae) fruit rind when combined with M. oleifera will increase the efficacy of the plant in the treatment of UC. Objective: The present work was undertaken to determine the effectiveness of M. oleifera root alone and in combination with C. sinensis fruit rind in the treatment of UC. Materials and methods: Ethanol and aqueous extracts of M. oleifera roots (100 and 200 mg/kg, body weight) were screened alone and in equal combination with ethanol extract of C. sinensis fruit rind, i.e., 50 mg/kg each of C. sinensis and M. oleifera for their activity on acetic acid-induced UC in mice. Results: Treatment with combination of extracts of M. oleifera root and C. sinensis fruit rind (50 mg/kg, each) showed less ulceration and hyperemia than individual extract (200 mg/kg) in histopathological observation. Acetic acid increased myeloperoxidase (MPO) level in blood and colon tissue to 342 U/mL and 384 U/mg, respectively. Combination of ethanol extract of M. oleifera root with C. sinensis fruit rind extract significantly (p < 0.05) decreased MPO in blood and tissue to 278 U/mL and 291 U/mg, respectively. MPO in blood and tissue in control group was 85 ± 1.2 U/mL and 96 ± 1.3 U/mg, respectively. Similarly this combination significantly reduced malondialdehyde (MDA) level in blood and tissue to 7.11 nmol/mL and 8.19 nmol/mg, from 11.20 nmol/mL and 13.20 nmol/mg, respectively. MDA in blood and tissue in control group was 2.76 ± 1.2 nmol/mL and 3.76 ± 1.2 nmol/mg, respectively. Discussion and conclusion: Results show that a combination of M. oleifera root extracts with C. sinensis fruit rind extract is effective in the treatment of UC and results are comparable with the standard drug prednisolone.
CYCLICAL OUTPUT - UNEMPLOYMENT RELATIONSHIP: OKUN’S LAW PARAMETER FOR TURKEY

The aim of this paper is twofold; to analyze the Okun’s law for Turkey and whether there exists a structural change in the relationship between cyclical output and unemployment after 2001 financial and economic crisis by using quarterly data from 1993 to end of 2008. Based on its “gap” specification and using different filtering methods-HP filter 1997, Baxter-King 1995, and Unobserved Component Model,-different than the previous literature, the results show that there exists significant inverse relationship between unemployment and output for Turkey. However, the quantitative value of Okun’s coefficient is relatively bigger than the developed countries’ coefficient reported by original papers for whole period. Also, the claim about the Turkish cyclical output and unemployment faced structural change after 2001 crisis did not find any empirical support.
ErbB2 Signaling Increases Androgen Receptor Expression in Abiraterone-Resistant Prostate Cancer

Purpose: ErbB2 signaling appears to be increased and may enhance androgen receptor (AR) activity in a subset of patients with castration-resistant prostate cancer (CRPC), but agents targeting ErbB2 have not been effective. This study was undertaken to assess ErbB2 activity in abiraterone-resistant prostate cancer and to determine whether it may contribute to AR signaling in these tumors. Experimental Design: AR activity and ErbB2 signaling were examined in the radical prostatectomy specimens from a neoadjuvant clinical trial of leuprolide plus abiraterone and in the specimens from abiraterone-resistant CRPC xenograft models. The effect of ErbB2 signaling on AR activity was determined in two CRPC cell lines. Moreover, the effect of combination treatment with abiraterone and an ErbB2 inhibitor was assessed in a CRPC xenograft model. Results: We found that ErbB2 signaling was elevated in residual tumor following abiraterone treatment in a subset of patients and was associated with higher nuclear AR expression. In xenograft models, we similarly demonstrated that ErbB2 signaling was increased and associated with AR reactivation in abiraterone-resistant tumors. Mechanistically, we show that ErbB2 signaling and subsequent activation of the PI3K/AKT signaling stabilizes AR protein. Furthermore, concomitantly treating CRPC cells with abiraterone and an ErbB2 inhibitor, lapatinib, blocked AR reactivation and suppressed tumor progression. Conclusions: ErbB2 signaling is elevated in a subset of patients with abiraterone-resistant prostate cancer and stabilizes AR protein. Combination therapy with abiraterone and ErbB2 antagonists may be effective for treating the subset of CRPC with elevated ErbB2 activity. Clin Cancer Res; 22(14); 3672–82. ©2016 AACR.
The Build-up of Auditory Stream Segregation: A Different Perspective

The build-up of auditory stream segregation refers to the notion that sequences of alternating A and B sounds initially tend to be heard as a single stream, but with time appear to split into separate streams. The central assumption in the analysis of this phenomenon is that streaming sequences are perceived as one stream at the beginning by default. In the present study, we test the validity of this assumption and document its impact on the apparent build-up phenomenon. Human listeners were presented with ABAB sequences, where A and B were harmonic tone complexes of seven different fundamental frequency separations (Δf) ranging from 2 to 14 semitones. Subjects had to indicate, as promptly as possible, their initial percept of the sequences, as either “one stream” or “two streams,” and any changes thereof during the sequences. We found that subjects did not generally indicate a one-stream percept at the beginning of streaming sequences. Instead, the first perceptual decision depended on Δf, with the probability of a one-stream percept decreasing, and that of a two-stream percept increasing, with increasing Δf. Furthermore, subjects required some time to make and report a decision on their perceptual organization. Taking this time into account, the resulting time courses of two-stream probabilities differ markedly from those suggested by the conventional analysis. A build-up-like increase in two-stream probability was found only for the Δf of six semitones. At the other Δf conditions no or only minor increases in two-stream probability occurred. These results shed new light on the build-up of stream segregation and its possible neural correlates.
Research of a Grid-enabled Parallel Computational Model and Algorithm Implementation

In this paper, a grid computational model and algorithm based on mind evolutional computation is constructed and implemented, which supports the dynamically resource allocation under grid environment. We investigate the grid enabled parallel computational model performance metrics, and proposed the Mind Evolutionary Computation based space decomposition parallel evolutionary algorithm , which simulates the human behavior and divides the population into the superior sub-populations and substitution sub-populations. The MEC based parallel evolutionary algorithm (MEPEA) has been successfully applied to Shanghai High Education Grid -realistic case studies. MEPEA algorithm included splicing/decomposable encoding scheme can solve computation intensive problems by using low- dimension algorithms. The proposed algorithm is experimentally testified with a test suit containing four complex function optimization benchmarks. The experiments all demonstrate that the proposed algorithm outperforms other algorithms in both scalability and solution quality.
Improvement of Leach Protocol for Wireless Sensor Networks

LEACH is a hierarchical routing protocol special for WSN. Many researchers have proposed many improved algorithms based on LEACH, such as LEACH-C, LEACH-M and so on, and these algorithms have much improvements on efficiency of energy in certain extent. Within the lifetime of networks, based on the shortcomings of LEACH that each node is frequently repeated several times elected cluster-head and consumed some energy, this paper proposes a hierarchical routing improved algorithm based on the LEACH algorithm(i.e., LEACH-R). The simulation results show that the improved algorithm makes the energy distribution more balanced, and LEACH-R outperforms LEACH-M nearly 20%.
The influence of an increased cobalt supply on ruminal parameters and microbial vitamin B12 synthesis in the rumen of dairy cows

The aim of the study was to examine the effects of an elevated dietary cobalt supply to dairy cows on rumen fermentation parameters and microbial vitamin B12 synthesis in the rumen. Five lactating dairy cows fitted with a ruminal and a duodenal cannula were subsequently fed either a ration containing only the native cobalt content (0.17 mg Co/kg DM) or a ration supplemented with cobalt sulphate (0.29 mg Co/kg DM). The pH-value, the ammonia concentration as well as the concentration and the molar proportions of short chain fatty acids in the rumen were not significantly influenced by feeding the ration with the higher cobalt content. While there was no difference in microbial protein flow, the cobalamin flow at the duodenum was significantly elevated in supplemented animals (3.67 ± 0.69 vs. 8.63 ± 2.22 mg B12/d). The efficiency of cobalt utilisation for ruminal vitamin B12 synthesis was calculated to be 7.1 ± 1.3% for the unsupplemented and 9.5 ± 2.4% for the supplemented ration. Further investigation has to prove if there are any benefits for cows resulting from the elevated cobalamin synthesis measured, caused by feeding higher amounts of dietary cobalt.
Evaluation of the double‐disk synergy test for New Delhi metallo‐β‐lactamase‐1 and other metallo‐β‐lactamase producing gram‐negative bacteria by using metal‐ethylenediaminetetraacetic acid complexes

New Delhi metallo‐β‐lactamase‐1 (NDM‐1), one of the metallo‐β‐lactamases (MBLs), has been identified from clinical isolates worldwide. Rapid detection of NDM‐1 producers is necessary to prevent their dissemination. Seven types of EDTA complexes were evaluated as MBL inhibitors in double‐disk synergy tests (DDSTs), resulting in detection of the first isolate of NDM‐1‐producing Escherichia coli (NDM‐1 Dok01) in Japan. NDM‐1 Dok01 was detected when EDTA magnesium disodium salt tetrahydrate (Mg‐EDTA), EDTA calcium disodium salt dihydrate, EDTA cobalt disodium salt tetrahydrate and EDTA copper disodium salt tetrahydrate were used as MBL inhibitors. The sensitivity and specificity of DDSTs using Mg‐EDTA for 75 MBL producers and 25 non‐MBL producers were 96.0% and 100%, respectively. These findings indicate that the DDST method using Mg‐EDTA can detect MBL‐producing strains, including NDM‐1 producers.
The Real Effects of Judicial Enforcement

This paper shows that judicial enforcement has substantial effects on firms’ decisions with regard to their employment policies. To establish causality, I exploit a reorganization of the court districts in Italy involving judicial district mergers as a shock to court productivity. I find that an improvement in enforcement, as measured by a reduction in average trial length, has a large, positive effect on firm employment. The cross-sectional heterogeneity of the results suggest that stronger enforcement reduces financing constraints, boosting employment as a result, especially in firms characterized by higher complementarity between labor and capital. Moreover, in the presence of stronger enforcement, firms can raise more debt to dampen the impact of negative shocks and, in this way, reduce employment fluctuations. Consistent with this result, worker-level evidence shows that strong enforcement reduces the likelihood of unemployment.