Miracle-dz/UniFAR-FTUs huggingface dataset:
Improvement of Forecasting Accuracy by the Utilization of Genetic Algorithm in the Case of the Sanitary Materials Data

Higher accurate forecasting in such fields as sales, shipping is an urgent necessity in industries. There are many researches made on this. In this paper, a hybrid method is introduced and plural methods are compared. Focusing that the equation of exponential smoothing method(ESM) is equivalent to (1,1) order ARMA model equation, new method of estimation of smoothing constant in exponential smoothing method is proposed before by us which satisfies minimum variance of forecasting error. Generally, smoothing constant is selected arbitrarily. But in this paper, we utilize above stated theoretical solution. Firstly, we make estimation of ARMA model parameter and then estimate smoothing constants. Thus theoretical solution is derived in a simple way and it may be utilized in various fields. Furthermore, combining the trend removing method with this method, we aim to improve forecasting accuracy. An approach to this method is executed in the following method. Trend removing by the combination of linear and 2 nd order non-linear function and 3 rd order non- linear function is executed to the manufacturer's data of sanitary materials. The weights for these functions are set 0.5 for two patterns at first and then varied by 0.01 increment for three patterns and optimal weights are searched. Genetic Algorithm is utilized to search the optimal weight for the weighting parameters of linear and non-linear function. For the comparison, monthly trend is removed after that. Theoretical solution of smoothing constant of ESM is calculated for both of the monthly trend removing data and the non-monthly trend removing data. Then forecasting is executed on these data. The new method shows that it is useful for the time series that has various trend characteristics and has rather strong seasonal trend. The effectiveness of this method should be examined in various cases.
Two Criteria for Evaluating Risk Prediction Models

Summary We propose and study two criteria to assess the usefulness of models that predict risk of disease incidence for screening and prevention, or the usefulness of prognostic models for management following disease diagnosis. The first criterion, the proportion of cases followed PCF (q), is the proportion of individuals who will develop disease who are included in the proportion q of individuals in the population at highest risk. The second criterion is the proportion needed to follow‐up, PNF (p), namely the proportion of the general population at highest risk that one needs to follow in order that a proportion p of those destined to become cases will be followed. PCF (q) assesses the effectiveness of a program that follows 100q% of the population at highest risk. PNF (p) assess the feasibility of covering 100p% of cases by indicating how much of the population at highest risk must be followed. We show the relationship of those two criteria to the Lorenz curve and its inverse, and present distribution theory for estimates of PCF and PNF. We develop new methods, based on influence functions, for inference for a single risk model, and also for comparing the PCFs and PNFs of two risk models, both of which were evaluated in the same validation data.
Safety, tolerability, pharmacokinetics and antitumor activity of ganitumab, an investigational fully human monoclonal antibody to insulin-like growth factor type 1 receptor, combined with gemcitabine as first-line therapy in patients with metastatic pancreatic cancer: a phase 1b study.

OBJECTIVE Previous Phase 1 studies have shown the acceptable safety profile of ganitumab-a fully human monoclonal antibody to insulin-like growth factor Type 1 receptor-in patients with advanced solid tumors. However, ganitumab 20 mg/kg in combination with gemcitabine had not been administered to patients with metastatic pancreatic cancer. To evaluate the safety, tolerability, pharmacokinetics and antitumor activity of ganitumab 20 mg/kg combined with gemcitabine 1000 mg/m(2) as first-line therapy in patients with metastatic pancreatic cancer, we conducted a Phase 1b study. METHODS Eligible patients were adults with previously untreated metastatic adenocarcinoma of the pancreas. Patients received gemcitabine 1000 mg/m(2) on Days 1, 8 and 15 plus ganitumab 20 mg/kg on Days 1 and 15 of each 28-day cycle. Gemcitabine was administered intravenously over 30-60 min. Ganitumab was administered intravenously over 60 min after completing gemcitabine infusion. RESULTS Six patients were enrolled and received the study treatment. All patients had thrombocytopenia and leukopenia. Other most common adverse events were neutropenia and nausea. One patient had a dose-limiting toxicity defined as Grade 3 neutropenia with fever. Exposure to ganitumab 20 mg/kg was not affected by the administration of gemcitabine. No apparent pharmacokinetic drug-drug interaction was observed. No anti-ganitumab antibodies were detected. Five patients had a measurable tumor region at baseline. Of these, four patients had a best response of stable disease. CONCLUSIONS Ganitumab 20 mg/kg combined with gemcitabine 1000 mg/m(2) was tolerable and showed an acceptable safety profile in patients with untreated metastatic pancreatic cancer.
Approximation of the Buckling Problem for Reissner-Mindlin Plates

This paper deals with the approximation of the buckling coefficients and modes of a clamped plate modeled by the Reissner-Mindlin equations. These coefficients are the reciprocals of the eigenvalues of a noncompact operator. We give a spectral characterization of this operator and show that the relevant buckling coefficients correspond to isolated nondefective eigenvalues. Then we consider the numerical computation of these coefficients and their corresponding modes. For the finite element approximation of Reissner-Mindlin equations, it is well known that some kind of reduced integration or mixed interpolation has to be used to avoid locking. In particular we consider Duran-Liberman elements, which have been already proved to be locking-free for load and vibration problems. We adapt the classical approximation theory for noncompact operators to obtain optimal order error estimates for the eigenfunctions and a double order for the eigenvalues. These estimates are valid with constants independent of the plate thickness. We report some numerical experiments confirming the theoretical results. Finally, we refine the analysis in the case of a uniformly compressed plate.
Cluster number selection for a small set of samples using the Bayesian Ying-Yang model

One major problem in cluster analysis is the determination of the number of clusters. In this paper, we describe both theoretical and experimental results in determining the cluster number for a small set of samples using the Bayesian-Kullback Ying-Yang (BYY) model selection criterion. Under the second-order approximation, we derive a new equation for estimating the smoothing parameter in the cost function. Finally, we propose a gradient descent smoothing parameter estimation approach that avoids complicated integration procedure and gives the same optimal result.
Beehive: O(1) Lookup Performance for Power-Law Query Distributions in Peer-to-Peer Overlays

Structured peer-to-peer hash tables provide decentralization, self-organization, failure-resilience, and good worst-case lookup performance for applications, but suffer from high latencies (O(log N)) in the average case. Such high latencies prohibit them from being used in many relevant, demanding applications such as DNS. In this paper, we present a proactive replication framework that can provide constant lookup performance for common Zipf-like query distributions. This framework is based around a closed-form optimal solution that achieves O(1) lookup performance with low storage requirements, bandwidth overhead and network load. Simulations show that this replication framework can realistically achieve good latencies, outperform passive caching, and adapt efficiently to sudden changes in object popularity, also known as flash crowds. This framework provides a feasible substrate for high-performance, low-latency applications, such as peer-to-peer domain name service.
Photon counting and timing detector modules for single-molecule spectroscopy and DNA analysis

Compact and rugged modules based on planar epitaxial single photon avalanche diode (SPAD) devices and monolithic active quenching and reset circuits (i-AQC) attain remarkable detector performance: quantum efficiency with 45% peak at 550 nm wavelength , dark-counting rate less than 10 c/s, photon timing better than 60 ps.
Explanation of Stagnation at Points that are not Local Optima in Particle Swarm Optimization by Potential Analysis

This paper investigates the frequently observed phenomenon of stagnation which appears on particle swarm optimization (PSO). We introduce a measure of significance of single dimensions and provide experimental and theoretical evidence that the classical PSO, even with swarm parameters known (from the literature) to be good, almost surely does not converge to a local optimum (stagnation) if too few particles are used. Stagnation is an undesirable property of PSO.
CD4+CD25+ regulatory T cells down‐regulate co‐stimulatory molecules on antigen‐presenting cells

CD4+CD25+ T cells have been shown to inhibit experimentally induced organ‐specific autoimmune disease and depletion of these regulatory T cells from normal mice results in development of such conditions. Furthermore, CD4+CD25+ T cells suppress the IL‐2 production and thereby the proliferation of polyclonally activated CD4+CD25– T cells in vitro. The suppression in vitro is independent of secreted factors but requires interactions between CD4+CD25– and CD4+CD25+ T cells and antigen‐presenting cells (APC). We have now further investigated the function of CD4+CD25+ T cells in vitro and have focused on their interactions with APC. We found that CD4+CD25+ T cells down‐regulated the expression of the co‐stimulatory molecules CD80 and CD86 on dendritic cells. The steady‐state level of CD80 mRNA was also decreased, while the steady‐state level of CD86 mRNA was not, suggesting that distinct mechanisms regulate the expression of these molecules. The down‐regulation occurred even in the presence of stimuli that would normally increase the expression of CD80 and CD86 molecules. Thus, down‐regulation of co‐stimulatory molecules may be an additional effector function of these regulatory T cells.
Graphical methods in statistical analysis.

The idea of graphical presentation of statistical data is a relatively recent development as compared with geometry , algebra, or even probability theory (18). The techniques of graphical presentation of data are still rapidly de­ veloping, as statistical theory opens new ways of thinking about data, and as using the capabilities of modem computers increasingly reshapes the body of . statistical practice-and theory. Before turning to some ofthe key graphical methods it is well first to look at a few broad issues.
Single-Domain Ferroelectric Water and its Concerted Diffusion in Nanotubes

The term ‘ferroelectric water’ has so far stood for ‘ferroelectric ice. ’ In molecular dynamics simulations, we find that, counter to intuition, single-domain ferroelectric water is possible inside carbon nanotubes open to a liquid water reservoir. Though this water is tube-shaped, it is strikingly different in structure and dynamics from ‘ice nanotubes. ’ A series of step-wise changes in net polarization of water and mobile/immobile water transitions are observed to occur spontaneously. This study not only improves our general knowledge of water, but is also suggestive of potential multifunctional capabilities of simple hydrophobic nanotubes for future applications.
GOLD : GPS and Optic Landing of Drones A Hybrid Approach

The successful use of drones for package delivery offers revolutionary cost savings for logistics providers. Today, the main barrier to drone delivery is the accuracy of drones during automated landings. GPS navigation accuracy is limited to a four meter radius, so getting drones to accurately and inexpensively navigate to the last few meters of precision is a major obstacle. This project creates a new accurate and cost-effective solution for hyper-accurate drone landing. GOLD combines GPS with optical navigation to iteratively recognize and descend towards a target landing spot. The system works by using the GPS navigation to send the drone to a high altitude above the target. The target landing spot is denoted on the ground with a QR-code poster. Next, the drone iteratively photographs the landscape beneath it, processes the image onboard and gradually descends towards the ground based on the sublocation of the QR-code in each photo taken. This hybrid approach offers an inexpensive, scalable, and accurate drone delivery system.This project also creates a web interface to manage all drone flight, delivery orders, and allocation of drones. For the proof of this concept, the website enables order fulfillment and allocation with a dynamic simulation interface.
Cross-recurrence quantification analysis of categorical and continuous time series: an R package

This paper describes the R package crqa to perform cross-recurrence quantification analysis of two time series of either a categorical or continuous nature. Streams of behavioral information, from eye movements to linguistic elements, unfold over time. When two people interact, such as in conversation, they often adapt to each other, leading these behavioral levels to exhibit recurrent states. In dialog, for example, interlocutors adapt to each other by exchanging interactive cues: smiles, nods, gestures, choice of words, and so on. In order for us to capture closely the goings-on of dynamic interaction, and uncover the extent of coupling between two individuals, we need to quantify how much recurrence is taking place at these levels. Methods available in crqa would allow researchers in cognitive science to pose such questions as how much are two people recurrent at some level of analysis, what is the characteristic lag time for one person to maximally match another, or whether one person is leading another. First, we set the theoretical ground to understand the difference between “correlation” and “co-visitation” when comparing two time series, using an aggregative or cross-recurrence approach. Then, we describe more formally the principles of cross-recurrence, and show with the current package how to carry out analyses applying them. We end the paper by comparing computational efficiency, and results’ consistency, of crqa R package, with the benchmark MATLAB toolbox crptoolbox (Marwan, 2013). We show perfect comparability between the two libraries on both levels.
The enigmatic trigeminal caroticodural fold

We describe our cadaveric dissections and clinical findings that address anterior and ventral limitations imposed by the trigeminal nerve. Particularly, we identify the trigeminal caroticodural fold, the vestment of dura that traverses the space between the nerve and the internal carotid artery. We address the effect of mobilization of this fold to optimize access in Kawase's space when approaching the clivus and posterior fossa.
Orthogonal‐plane fluorescence optical sectioning: Three‐dimensional imaging of macroscopic biological specimens

An imaging technique called orthogonal‐plane fluorescence optical sectioning (OPFOS) was developed to image the internal architecture of the cochlea. Expressions for the three‐dimensional point spread function and the axial and lateral resolution are derived. Methodologies for tissue preparation and for construction, alignment, calibration and characterization of an OPFOS apparatus are presented. The instrument described produced focused, high‐resolution images of optical sections of an intact, excised guineapig cochlea. The lateral and axial resolutions of the images were 10 and 26 μm, respectively, within a 1·5‐mm field of view.
Application of Eucalyptus sawdust on strain production of edible fungi.

【Objective】Using Eucalyptus sawdust as raw material, medium formula suitable for pleurotus, Auricularia auricular and other conventional edible fungi were screened so as to provide scientific references for producing edible fungi strains with Eucalyptus sawdust in Guangxi. 【Method】Orthogonal experiment with 3 factors and 3 levels was conducted to compare the effect of different ratios of Eucalyptus sawdust, mulberry sawdust and cottonseed hull on the mycelia growth of pleurotus and Auricularia auricular. 【Result】Pleurotus and Auricularia auricular could grow normally in the media with dif-ferent proportions of Eucalyptus sawdust. Especially in b, c, f and i media they grew fast and had pure white, thick and bushy mycelium with superior connection effect. 【Conclusion】Reasonable proportion of Eucalyptus sawdust can be used as the main materials in Pleurotus and Auricularia auricular production. Formula f and i with higher proportion of Eucalyptus saw-dust and mulberry sawdust, and lower proportion of cottonseed hull should be applied to produce strains at low cost.
Effect of Endogenous Bone Marrow Derived Stem Cells Induced by AMD-3100 on Expanded Ischemic Flap

The purpose of this study was to devise an expanded ischemic flap model and to investigate the role of AMD-3100 (Plerixafor, chemokine receptor 4 inhibitor) in this model by confirming its effect on mobilization of stem cells from the bone marrow. Male Sprague-Dawley rats were used as an animal research model. The mobilization of stem cells from the bone marrow was confirmed in the AMD-3100-treated group. The fractions of endothelial progenitor cells (EPC) and the vascular endothelial growth factor receptor (VEGFR) 2+ cells in the peripheral blood were increased in groups treated with AMD-3100. The expression of vascular endothelial growth factor (VEGF) was increased in response to expansion or AMD injection. The expression of stromal cell derived factor (SDF)-1 and VEGFR2 were increased only in unexpanded flap treated with AMD-3100. Treatment with AMD-3100 increased both the number and area of blood vessels. However, there were no statistically significant differences in the survival area or physiologic microcirculation in rats from the other groups. This endogenous neovascularization induced by AMD-3100 may be a result of the increase in both the area and number of vessels, as well as paracrine augmentation of the expression of VEGF and EPCs. However, the presence of a tissue expander under the flap could block the neovascularization between the flap and the recipient regardless of AMD-3100 treatment and expansion. Graphical Abstract
The Myth of Child Malnutrition in India

A common continuing criticism of the economic reforms in India has been that despite accelerated growth and all-around poverty reduction, the country continues to suffer from child malnutrition that is worse than nearly all of the Sub Saharan African countries with lower per-capita incomes. Nearly half of Indiaâ€™s under-five children are said to be underweight and stunted. Prime Minister Manmohan Singh recently described the problem as â€˜a matter of national shame. â€™ I argue in this paper that this narrative, nearly universally accepted around the world, is both false and counter-productive from the viewpoint of policy formulation. It is purely an artifact of a faulty methodology that the World Health Organization has pushed and the United Nations has supported. If the numbers are correctly done, in all likelihood, India will have no more to be ashamed of its achievements in child nutrition than vital statistics such as life expectancy, infant mortality and maternal mortality.
Low cytoplasmic pH inhibits endocytosis and transport from the trans- Golgi network to the cell surface

A fibroblast mutant cell line lacking the Na+/H+ antiporter was used to study the influence of low cytoplasmic pH on membrane transport in the endocytic and exocytic pathways. After being loaded with protons, the mutant cells were acidified at pH 6.2 to 6.8 for 20 min while the parent cells regulated their pH within 1 min. Cytoplasmic acidification did not affect the level of intracellular ATP or the number of clathrin- coated pits at the cell surface. However, cytosolic acidification below pH 6.8 blocked the uptake of two fluid phase markers, Lucifer Yellow and horseradish peroxidase, as well as the internalization and the recycling of transferrin. When the cytoplasmic pH was reversed to physiological values, both fluid phase endocytosis and receptor- mediated endocytosis resumed with identical kinetics. Low cytoplasmic pH also inhibited the rate of intracellular transport from the Golgi complex to the plasma membrane. This was shown in cells infected by the temperature-sensitive mutant ts 045 of the vesicular stomatitis virus (VSV) using as a marker of transport the mutated viral membrane glycoprotein (VSV-G protein). The VSV-G protein was accumulated in the trans-Golgi network (TGN) by an incubation at 19.5 degrees C and was transported to the cell surface upon shifting the temperature to 31 degrees C. This transport was arrested in acidified cells maintained at low cytosolic pH and resumed during the recovery phase of the cytosolic pH. Electron microscopy performed on epon and cryo-sections of mutant cells acidified below pH 6.8 showed that the VSV-G protein was present in the TGN. These results indicate that acidification of the cytosol to a pH less than 6.8 inhibits reversibly membrane transport in both endocytic and exocytic pathways. In all likelihood, the clathrin and nonclathrin coated vesicles that are involved in endo- and exocytosis cannot pinch off from the cell surface or from the TGN below this critical value of internal pH.
Impact of the visitor pattern on program comprehension and maintenance

In the software engineering literature, many works claim that the use of design patterns improves the comprehensibility of programs and, more generally, their maintainability. Yet, little work attempted to study the impact of design patterns on the developers' tasks of program comprehension and modification. We design and perform an experiment to collect data on the impact of the Visitor pattern on comprehension and modification tasks with class diagrams. We use an eye-tracker to register saccades and fixations, the latter representing the focus of the developers' attention. Collected data show that the Visitor pattern plays a role in maintenance tasks: class diagrams with its canonical representation requires less efforts from developers.
Deciphering actin cytoskeletal function in the contractile vascular smooth muscle cell

Abstract This review focuses on the vascular smooth muscle cells present in the medial layer of the blood vessels wall in the fully differentiated state (dVSMCs). The dVSMC contractile phenotype enables these cells to respond in a highly regulated manner to changes in extracellular stimuli. Through modulation of vascular contractile force and vascular compliance dVSMCs regulate blood pressure and blood flow. The cellular and molecular mechanisms by which vascular smooth muscle contractile functions are regulated are not completely elucidated. Recent studies have documented a critical role for actin polymerization and cytoskeletal dynamics in the regulation of contractile function. Here we will review the current understanding of actin cytoskeletal dynamics and focal adhesion function in dVSMCs in order to better understand actin cytoskeleton connections to the extracellular matrix and the effects of cytoskeletal remodelling on vascular contractility and vascular stiffness in health and disease.