Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of a primary care physician task list to evaluate clinic visit workflow

Background Interventions designed to improve the delivery of primary care, including Patient-Centered Medical Homes and electronic health records, require an understanding of clinical workflow to be successfully implemented. However, there is a lack of tools to describe and study primary care physician workflow. We developed a comprehensive list of primary care physician tasks that occur during a face-to-face patient visit. Methods A validated list of tasks performed by primary care physicians during patient clinic visits was developed from a secondary data analysis of observation data from two studies evaluating primary care workflow. Thirty primary care physicians participated from a convenience sample of 17 internal medicine and family medicine clinics in Wisconsin and Iowa across rural and urban settings and community and academic settings. Results The final task list has 12 major tasks, 189 subtasks, and 191 total tasks. The major tasks are: Enter Room, Gather Information from Patient, Review Patient Information, Document Patient Information, Perform, Recommend / Discuss Treatment Options, Look Up, Order, Communicate, Print / Give Patient (advice, instructions), Appointment Wrap-up, and Leave Room. Additional subcodes note use of paper or EHR and the presence of a caregiver or medical student. Conclusions The task list presented here is a tool that will help clinics study their workflows so they can plan for changes that will take place because of EHR implementation and/or transformation to a patient centered medical home.
Influence of Cultivation Media on Genetic Regulatory Patterns in Borrelia burgdorferi

ABSTRACT Barbour-Stoenner-Kelly II (BSKII) medium and BSKH medium both are routinely used for the cultivation of Borrelia burgdorferi. However, heretofore there have been no studies to compare how these two media affect gene expression patterns in virulentB. burgdorferi. In the present study, we found that someB. burgdorferi strain 297 genes (e.g.,ospA, mlp-7A, mlp-8,p22, and lp6.6) that typically are regulated by temperature or pH displayed their predicted pattern of expression when B. burgdorferi was cultivated in BSKH medium; this was not true when spirochetes were cultivated in conventional BSKII medium. The results suggest that BSKH medium is superior to BSKII medium for gene expression studies with B. burgdorferi.
Effective collection of peripheral blood stem cells in children weighing 20 kilogram or less in a single large‐volume apheresis procedure

Introduction: Peripheral blood stem cell (PBSC) transplantation has become a routine procedure in pediatric oncology. A special group of PBSC donors are children weighing 20 kg or less. Limited vascular access and low blood volume puts them at a higher risk. Central line placement and a priming apheresis machine are recommended to avoid these complications. Patients and Methods: PBSC collections performed from July 2006 to May 2013 in children weighing less than 20 kg were included. All donors had a central venous catheter (CVC). An apheresis machine was primed with packet red blood cells. Results: Twenty‐seven PBSC collections were performed in 22 children weighing 20 kg or less, 14 for allogeneic and 8 for autologous transplantation, in order to collect at least 2 × 106 CD34+ cells/kg. In the allogeneic group, median age and weight were 3 years (0.8–7) and 15.5 kg (8–20). In the autologous group, median age and weight were 3 years (2–7) and 15.35 kg (12.5–19.5). A single large‐volume apheresis was sufficient to obtain the CD34+ cells needed in 78.5% and 75% of the allogeneic and autologous groups, respectively, with a median 11.84 × 106 and 5.79 × 106 CD34+ cells collected per kilogram of weight of the recipient. No serious complications related to the apheresis procedure or CVC placement occurred. Conclusion: PBSC collection in a single large‐volume apheresis for allogeneic and autologous transplants in children weighing 20 kg or less is a safe and effective procedure when based on standardized protocols. J. Clin. Apheresis 30:281–287, 2015. © 2014 Wiley Periodicals, Inc.
Red Blood Cell Eicosapentaenoic Acid Inversely Relates to MRI-Assessed Carotid Plaque Lipid Core Burden in Elders at High Cardiovascular Risk

Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 older individuals at high vascular risk grouped into different stages of carotid atherosclerosis severity, including those without ultrasound-detected atheroma plaque (n = 38), with plaques <2.0 mm thick (n = 65), and with plaques ≥2.0 mm (n = 79). The latter were asked to undergo contrast-enhanced 3T magnetic resonance imaging (MRI) and were subsequently grouped into absence (n = 31) or presence (n = 27) of MRI-detectable plaque lipid, a main feature of unstable atheroma plaques. We determined the red blood cell (RBC) proportion of EPA (a valid marker of long-term EPA intake) at enrolment by gas chromatography. In multivariate models, EPA related inversely to MRI-assessed plaque lipid volume, but not to maximum intima-media thickness of internal carotid artery, plaque burden, or MRI-assessed normalized wall index. The inverse association between EPA and plaque lipid content in patients with advanced atherosclerosis supports the notion that this fatty acid might improve cardiovascular health through stabilization of advanced atheroma plaques.
A high-performance DSP-controller for parallel operation of online UPS systems

In this paper, a novel controller for parallel-connected online uninterruptible power supplies (UPS) without control interconnections based on the droop method is presented. The control approach consists in drop the frequency of every module when its output power increases, resulting in an unavoidable nominal frequency deviation. Consequently, this method in its original form is only applicable to off-line or line-interactive UPS systems. As opposed to the conventional droop method, the proposed control scheme endows proper transient response, strictly frequency and phase synchronization with the AC mains, and excellent power sharing even for nonlinear loads. Hence, this controller is suitable for paralleled online UPS systems. Experimental results are obtained from two parallel-connected 1-kVA online UPS by using TMS320LF2407A DSP.
Notice of RetractionInvestegation based study on the environment and opportunities of mobile payment services in China

In this paper, we study the environment and opportunities of mobile payment services in China. Firstly, we examine the macro environment, analyzing the government policies and laws, the economic status, the social and cultural trends and the technology evolvement and their effect on the development of mobile payment. Secondly, we study the industrial environment of mobile payment in China with an emphasis on the consumers and merchants sides. Based on an in-depth investigation made in five representative provinces in China, consumers' adoptive attitudes and merchants' participation motives are identified through focus-group interviews, one to one interviews and a large sample telephone survey. And then, the competition advantages of mobile payment services providers and the competitors, including banks and other e-payment services providers, are comprised. Finally, by learning the experiences and lessons from Japan, South Korea and the European and American countries in their development of mobile payment services, suggestions on future development of mobile payment services in China are proposed. The main findings of this study can be summarized as follow: consumers in China have a high demand of mobile payment services in different application fields; merchants show their interests to this new payment tool concerning its convenience, efficiency and huge potential customers; and mobile services operators in China are the most active facilitators of mobile payment services. The future of mobile payment development in China is determined by some key factors: the support from government policy makers, the efforts of mobile services operators and the cooperation among the participants in the industrial chain under the principle of mutual benefits.
Repeated failures to obtain selective directed forgetting in lab and online samples and variations in stimuli

ABSTRACT Previous research has produced mixed findings as to whether it is possible to selectively forget a subset of items while maintaining access to the remaining items from the same episode, using a modified version of the list-method directed forgetting (LMDF) paradigm. The present study includes six attempts to obtain the selective directed forgetting (SDF) effect with the aim of exploring its underlying mechanisms. However, despite variations in the stimuli and samples, which included both lab and online participants, we failed to obtain SDF across five experiments. In one of the experiments, we observed what appeared to be an SDF effect; however, the unexpected baseline differences across the conditions make the interpretation of this result equivocal. In contrast, standard directed forgetting effect was obtained when an LMDF condition was included in the design. An evaluation of the previous literature in combination with the present study raises questions about the reliability of the SDF phenomenon.
Women with PSVT are often misdiagnosed, referred later than men, and have more symptoms after ablation

Abstract Objectives. Using a patient and gender perspective, this study evaluates the experiences and perspectives of referral for paroxysmal supraventricular tachycardia (PSVT), and symptoms, Health-Related Quality of Life (HRQOL) and functional impairment before and six months after ablation. Design. This prospective study includes 214 (109 women) patients with PSVT who completed questionnaires before and after ablation addressing referral patterns, duration of arrhythmia, socioeconomic status, symptoms, HRQOL, and functional impairment. Result. Women had a longer history of symptomatic arrhythmia before ablation compared to men (16.2 ± 14.6 vs. 9.9 ± 13.1 years, p = .001). From the patient’s perspective, physicians more often incorrectly interpreted women’s symptoms as anxiety, stress, panic attacks, or depression compared to men, delaying referral for ablation. More women than men stated they were not taken seriously when consulting for their tachycardia symptoms (17% vs.7%, p = .03). At baseline, there were minor differences between the sexes in HRQOL and functional impairment, but women had a higher symptom score on Symptoms Checklist Frequency (19 vs. 14, p < .001) and Severity Scale (12 vs. 16, p = .001). At six months, women were more symptomatic and their HRQOL improved less than in men. Both sexes reported improvement in recreation and pastime (p = .001). Conclusion. Women with PSVT are referred for ablation later, and are more symptomatic before and after ablation than men. Symptoms due to PSVT are often incorrectly diagnosed as panic attacks, stress, anxiety, or depression, misdiagnoses that delay referral for ablation, especially for women.
Reflection and Rotation Invariant Uniform Patterns for Texture Classification

SUMMARY In this letter, we propose a novel texture descriptor that takes advantage of an anisotropic neighborhood. A brand new encoding scheme called Reﬂection and Rotation Invariant Uniform Patterns (rriu2) is proposed to explore local structures of textures. The proposed descriptor is called Oriented Local Binary Patterns (OLBP). OLBP may be incorporated into other varieties of Local Binary Patterns (LBP) to obtain more powerful texture descriptors. Experimental results on CUReT and Outex databases show that OLBP not only signiﬁcantly outperforms LBP, but also demonstrates great robustness to rotation and illuminant changes. key words:
Differential effects of low‐ and high‐dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion

Aberrant expression of epidermal growth factor receptor (EGFR; ErbB1) and HER2 (ErbB2) tyrosine kinases frequently occurs in glioblastoma multiforme (GBM) patients and is considered to be associated with tumor malignancy and poor patient prognosis. In the present study, a dual EGFR and HER2 inhibitor (GW2974) was evaluated for its effects in GBM in vitro and in vivo. Results showed that low‐concentration GW2974 inhibited GBM cell invasion, whereas a high concentration of the same compound counteracted this effect. Similar results were observed in an intracranial GBM xenograft model, in which, although both doses of GW2974 slowed tumor growth, no improvement in survival was observed in mice treated with high‐dose GW2974, presumably because of the augmentation of tumor invasion. By protein microarray and Western blot analyses, the p38 mitogen‐activated protein kinase (MAPK) pathway was found to be activated in GBM cells under high‐concentration GW2974. Additionally, blockage of the p38 MAPK pathway reproduced the inhibitory effect of low‐concentration GW2974 on cell invasion. These data suggest that the p38 MAPK pathway might contribute to the differential regulation of cell invasion by GW2974. Taken together, our results indicate that GW2974 exerts different effects in GBM depending on drug dosage. This offers a new perspective on the role of GW2974 in tumor progression, providing a potential strategy for GBM treatment based on precise prescription. © 2012 Wiley Periodicals, Inc.
DNA Topoisomerase II Is Dispensable for Oocyte Meiotic Resumption but Is Essential for Meiotic Chromosome Condensation and Separation in Mice1

ABSTRACT During mitosis, DNA topoisomerase II (TOP2) is required for sister chromatid separation. When TOP2 activity is inhibited, a decatenation checkpoint is activated by entangled chromatin. However, the functions of TOP2 in oocyte meiosis, particularly for homologous chromosome segregation during meiosis I, have not been investigated. In addition, it remains unknown if TOP2 inhibition activates a decatenation checkpoint at the G2/M transition in oocytes. In this study, we used mouse oocytes and specific inhibitors of TOP2 (ICRF-193 and etoposide) to investigate the role of TOP2 in meiosis. Our results indicated that an effective decatenation checkpoint did not exist in fully grown oocytes, as oocytes underwent the G2/M transition and reinitiated meiosis even when TOP2 activity was inhibited. However, oocytes treated with ICRF-193 had severe defects in chromosome condensation and homologous chromosome separation. Furthermore, condensed chromosomes failed to maintain their normal configurations in matured oocytes that were treated with ICRF-193. However, sister chromatid separation and subsequent chromosome decondensation during the exit from meiosis were not blocked by TOP2 inhibitors. These results indicated that TOP2 had a specific, crucial function in meiosis I. Thus, we identified important functions of TOP2 during oocyte maturation and provided novel insights into the decatenation checkpoint during meiosis.
CD4+CD25high Regulatory T Cells Are Markedly Decreased in Blood of Patients with Pemphigus Vulgaris

Background: It remains to be determined whether pemphigus vulgaris (PV), an autoimmune blistering disease, has a reduction and/or dysfunction of CD4+CD25high regulatory T (Treg) cells. Objectives: To evaluate the frequency and phenotypes of Treg cells in blood of patients with PV. Methods: Peripheral blood mononuclear cells were prepared from PV patients as well as normal and disease control volunteers, and the frequency and phenotypes of Treg cells were determined by flow cytometry. CD4+CD25+ and CD4+CD25– T cells isolated from peripheral blood mononuclear cells of PV patients and normal controls were subjected to real-time semiquantitative RT-PCR for the expression of Foxp3 gene. Results: The proportion of Treg cells in all PV patients was severely reduced, approximately ten times less than controls. These observations were further confirmed by both diminished gene and protein expression of Foxp3 in the CD4+CD25+ T cell population in PV patients. Conclusions: Numerical impairment of Treg cells may be involved in the pathogenesis of PV.
Hierarchical route planning based on taxi GPS-trajectories

The popular methods of route planning, the planar and hierarchical algorithms, are mainly based on the Dijkstra's algorithm. The shortest path in machine computation is always different from the optimal one in a human cognition because travel experience information of human is neglected. In this paper,hierarchical travel experience information of road network is given by statistical analysis on a large amount of taxi GPS trajectories. According to taxi trajectories, the roads can be divided into frequent roads, secondary frequent roads and seldom roads. These trajectories can well reflect a hierarchical cognition of road network because considering taxi driver's cognition of the road network. With the hierarchical model of road network, the corresponding hierarchical route planning can be performed based on the experienced driver's cognition. The experiments show that the route results according to the experiential information approach to optimal results more than that according to static information of road network.
The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness

Objective Novelty seeking is a trait that has been consistently associated with problem behaviours. There is evidence for heritability of novelty seeking, but the molecular genetic basis of the trait is still widely unclear. Methods The interaction between polymorphisms of catechol-O-methyltransferase (COMT) and serotonin receptor 2A genes was examined in relation to novelty seeking and its different subscales in healthy Finnish adults. A subsample of 1214 participants derived from a population-based sample was genotyped for the COMT Val158Met (rs4680) and HTR2A T102C (rs6313) genes. Novelty seeking was measured twice, with a 4-year interval, using Cloninger's Temperament and Character Inventory. Results The interaction between COMT Val158Met and HTR2A T102C polymorphisms was found to be associated with subscale impulsiveness. T/T carriers of HTR2A T102C polymorphism, that also had Met/Met genotype of COMT Val158Met single nucleotide polymorphism, scored significantly higher on impulsiveness than Val allele carriers (P=0.005). Conclusion Our results suggest that the interaction between dopaminergic and serotonergic genes might underlie impulsiveness. Together with earlier research our results also stress the importance of considering novelty seeking as a heterogeneous trait with its subscales having different genetic backgrounds.
Copula directed acyclic graphs

A new methodology for selecting a Bayesian network for continuous data outside the widely used class of multivariate normal distributions is developed. The ‘copula DAGs’ combine directed acyclic graphs and their associated probability models with copula C/D-vines. Bivariate copula densities introduce flexibility in the joint distributions of pairs of nodes in the network. An information criterion is studied for graph selection tailored to the joint modeling of data based on graphs and copulas. Examples and simulation studies show the flexibility and properties of the method.
ELECTROENCEPHALOGRAPHIC AND BEHAVIORAL STUDIES OF MONOMETHYLHYDRAZINE TOXICITY IN THE CAT

ABSTRACT The toxicity of monomethyl hydrazine (MMH) administered intraperitoneally in the cat was studied by reference to behavioral and neurophysiological indices. The acute lethal toxicity value (LD50) for MMH was established at 15 mg/kg, and the convulsive toxicity value (CD50) at 7 m/kg. Doses of 18, 9, and 5 mg/kg were then studied systematically in an effort to classify lethal, convulsive, and subconvulsive symptoms. For these doses, a preconvulsive syndrome was described involving recurrent and sustained symptoms, including vomiting, panting, rapid respiration, viscous salivation, hyperactivity, and subcortical seizure activity. The onset latency of these symptoms was directly related to dose. Several lines of evidence suggested at least a partial independence between biochemical and neurophysiological events responsible, on one hand, for convulsions and, on the other, for this preconvulsive syndrome. Convulsions were specifically delayed or prevented in animals trained to suppress movement through.
A spurious-free tunable bandpass filter

This paper presents a simple structure for suppressing the second-harmonic of tunable filters. The proposed resonator for the filter possesses the advantage that its resonant frequencies of odd-mode can be electrically tuned, whereas the even-mode harmonics can be suppressed. In addition, it is very simple and compact in structure. Based on the proposed resonator, a tunable filter with harmonic suppression has been implemented and compared to the counterpart without harmonic suppression. The comparison shows the second harmonics can be effectively suppressed with little impact on the passband performance.
Psychological Violence Experienced by Men Who Have Sex With Men in Puducherry, India: A Qualitative Study

Men who have sex with men are a hidden population in India. This study explores the psychological violence such men are exposed to in Puducherry, India. Eleven in-depth interviews probe experiences of blackmail, discrimination, and rejection. Some informants modified their behaviors or appearances to avoid harassment and safeguard their families' reputations. Others told how Indian men accepted their behaviors, but rejected their identities. Social pressure to marry was also a recurring theme. Understanding the factors behind these violent experiences may facilitate their amelioration.
Enhancing Virtual Presence in E-Tail: Dynamics of Cue Multiplicity

Visual simulation is currently the primary technique used to optimize virtual presence in e-tailing, but it entails high costs. For e-tail companies with limited financial resources, customer-company communications, instead of using visual simulation, are based mostly on text (e.g., product attributes, company information). This study explores the influence of text-based e-tail content on virtual presence and the mechanism underlying this influence by testing (1) the effect of cue multiplicity on telepresence and social presence and (2) the dynamics of how presence perceptions affect decision affirmation. A total of 407 participants in the main experiment were exposed to a fictitious e-tail Web site, and the cue multiplicity of the text-based e-tail content was manipulated. The results supported all the hypotheses but one. First, a greater number of cues led to greater perception of telepresence and social presence, providing support for the hypothesized effect of cue multiplicity in text-based e-tail content on virtual presence. Second, telepresence increased Web site trust, ultimately contributing to shoppers' decision affirmation; however, the effect of telepresence on e-shopping enjoyment was not confirmed. Finally, social presence significantly improved Web site trust, e-shopping enjoyment, and social affirmation, all of which improved decision affirmation. The findings illuminate the role of cue multiplicity in e-tail text as a crucial antecedent to virtual presence and decision affirmation. A strategic manipulation of e-tail text should be further considered by managers of various virtual marketplaces as a cost-efficient and effective way of helping the shopper's decision process.