Miracle-dz/UniFAR-FTUs huggingface dataset:
Video system for human attribute analysis using compact convolutional neural network

Convolutional neural networks show their advantage in human attribute analysis (e.g. age, gender and ethnicity). However, they experience issues (e.g. robustness and responsiveness) when deployed in an intelligent video system. We propose one compact CNN model and apply it in our video system motivated by the full consideration of performance and usability. With the proposed web image mining and labelling strategy, we construct a large training set which covers various image conditions. The proposed CNN model successfully achieves a mean absolute error (MAE) of 3.23 years on the Morph 2 dataset, using the same test policy as our counterparts. This is the state-of-the-art score to our knowledge using CNN for age estimation. The proposed video analysis system employs this compact CNN model and demonstrated good performance in both dataset tests and deployment in real-world environments.
β-Agonist-mediated Relaxation of Airway Smooth Muscle Is Protein Kinase A-dependent*

Background: Mechanisms by which β-2-adrenoreceptor agonists effect bronchorelaxation remain unestablished. Results: Direct inhibition of PKA via molecular approaches reversed β-agonist-mediated antagonism of procontractile signaling and relaxation of contracted airway smooth muscle (ASM) despite augmenting intracellular cAMP. Conclusion: PKA is the primary mechanism by which β-agonists relax ASM. Significance: PKA-dependent signaling and functions should guide the development of bronchodilator drugs. Inhaled β-agonists are effective at reversing bronchoconstriction in asthma, but the mechanism by which they exert this effect is unclear and controversial. PKA is the historically accepted effector, although this assumption is made on the basis of associative and not direct evidence. Recent studies have asserted that exchange protein activated by cAMP (Epac), not PKA, mediates the relaxation of airway smooth muscle (ASM) observed with β-agonist treatment. This study aims to clarify the role of PKA in the prorelaxant effects of β-agonists on ASM. Inhibition of PKA activity via expression of the PKI and RevAB peptides results in increased β-agonist-mediated cAMP release, abolishes the inhibitory effect of isoproterenol on histamine-induced intracellular calcium flux, and significantly attenuates histamine-stimulated MLC-20 phosphorylation. Analyses of ASM cell and tissue contraction demonstrate that PKA inhibition eliminates most, if not all, β-agonist-mediated relaxation of contracted smooth muscle. Conversely, Epac knockdown had no effect on the regulation of contraction or procontractile signaling by isoproterenol. These findings suggest that PKA, not Epac, is the predominant and physiologically relevant effector through which β-agonists exert their relaxant effects.
Advances in Web Service-Driven Cartography

Service-driven cartography deals with the development of highquality interactive cartographic online applications based on an interworking of Web services and Web technologies. The main advantages of servicedriven cartography are the creation of Web-based cartographic products with content extracted directly from geospatial databases, the rich cartographic output and the up-to-date visualizations. In this contribution, after a brief review of the core concepts of servicedriven cartography we will focus on recent advances in the field performed by our group. These recent advances demonstrate the applicability of service-driven cartography for the implementation of 2D and 3D atlases.
Divergent Evolution of CHD3 Proteins Resulted in MOM1 Refining Epigenetic Control in Vascular Plants

Arabidopsis MOM1 is required for the heritable maintenance of transcriptional gene silencing (TGS). Unlike many other silencing factors, depletion of MOM1 evokes transcription at selected loci without major changes in DNA methylation or histone modification. These loci retain unusual, bivalent chromatin properties, intermediate to both euchromatin and heterochromatin. The structure of MOM1 previously suggested an integral nuclear membrane protein with chromatin-remodeling and actin-binding activities. Unexpected results presented here challenge these presumed MOM1 activities and demonstrate that less than 13% of MOM1 sequence is necessary and sufficient for TGS maintenance. This active sequence encompasses a novel Conserved MOM1 Motif 2 (CMM2). The high conservation suggests that CMM2 has been the subject of strong evolutionary pressure. The replacement of Arabidopsis CMM2 by a poplar motif reveals its functional conservation. Interspecies comparison suggests that MOM1 proteins emerged at the origin of vascular plants through neo-functionalization of the ubiquitous eukaryotic CHD3 chromatin remodeling factors. Interestingly, despite the divergent evolution of CHD3 and MOM1, we observed functional cooperation in epigenetic control involving unrelated protein motifs and thus probably diverse mechanisms.
A low power CMOS front-end for photoplethysmongraphic signal acquisition with robust DC Photocurrent Rejection

A micro-power CMOS front-end for photoplethysmographic signal (PPG) acquisition is presented. The circuit is composed of a transimpedance amplifier (TIA), post amplifier and low-pass filter. The TIA is configured with a sample-and-hold (S/H), an error amplifier and a current-sink transistor in feedback to reject DC photocurrent generated from photodiode, which varies from person to person. To reduce power consumption, the LED is pulsed and thus the input to the TIA is a modulated current pulse. The low-pass filter is implemented by using the current-steering technique (CST). The proposed circuit is designed to generate PPG waveform with a fixed DC output to prevent signal saturation by rejecting the input pulsating DC photocurrent from modulated signal. Experimental results show that the circuit works properly from a 2.5-V power supply with a bandpass frequency from 0.1 Hz to 6.5 Hz and has a rejection range from 0.1 muA to 53.6 muA.
Distinct Mechanisms Trigger Apoptosis in Human Immunodeficiency Virus Type 1-Infected and in Uninfected Bystander T Lymphocytes

ABSTRACT Apoptosis is a main feature of AIDS pathogenesis and is thought to play a role in the progressive decrease of CD4+ T lymphocytes in infected individuals. To determine whether apoptosis occurs in infected and/or in uninfected peripheral blood T lymphocytes, we have used a recombinant human immunodeficiency virus type 1 (HIV-1) infectious clone expressing the green fluorescent protein (GFP). Using flow cytometry, we have determined the incidence of apoptosis by either terminal transferase dUTP nick end labeling or annexin-V assays in different cell subpopulations, i.e., in CD4+ or CD8+ T cells that were GFP positive or negative. After HIV-1 infection of purified peripheral blood lymphocytes, we observed that apoptosis occurred mostly in infected CD4+ peripheral blood lymphocytes. Remarkably, the presence of monocyte-derived macrophages in the culture increased dramatically the apoptosis of uninfected bystander T lymphocytes, while apoptosis in HIV-infected T lymphocytes was not changed. We therefore demonstrate that HIV-induced apoptosis results from at least two distinct mechanisms: (i) direct apoptosis in HIV-infected CD4+ T lymphocytes and (ii) indirect apoptosis in uninfected T cells mediated by antigen-presenting cells.
Earthquake and Physical and Social Vulnerability Assessment for Settlements : Case Study Avcilar District

In this study, a vulnerability assessment model has been developed for earthquake prone areas in Turkey. The vulnerability assessment model includes ground factors, building's physical conditions, and social (demographic and socioeconomic) aspects of the settlement. This vulnerability assessment model is applied to a case study that of the Avcılar district of Istanbul. Forty different reinforced concrete residential buildings of 1225 people are assessed using the developed checklist. In order to evaluate the checklist and to assess the importance (relevance) of vulnerability factors, a questionnaire is forwarded to various related professional groups (architecture, urban planning and civil engineering). The results of the questionnaire are examined using SPSS software with factor analysis. According to the results, most of the samples in the case study area can be classified as high vulnerable. Blank line 10 pt
Efficient Extraction of Pseudo-Parallel Sentences from Raw Monolingual Data Using Word Embeddings

We propose a new method for extracting pseudo-parallel sentences from a pair of large monolingual corpora, without relying on any document-level information. Our method first exploits word embeddings in order to efficiently evaluate trillions of candidate sentence pairs and then a classifier to find the most reliable ones. We report significant improvements in domain adaptation for statistical machine translation when using a translation model trained on the sentence pairs extracted from in-domain monolingual corpora.
Comparison Between Manually and Automatically Assigned Descriptors Based on a German Bibliographic Collection

This paper compares and illustrates the use of manually and automatically assigned descriptors on German documents extracted from the GIRT Corpus. A second objectives to analyze the usefulness of both specialized or general thesauri to automatically enhance queries. To illustrate our results we use different search models such as a vector space model, a language model and two probabilistic models. We also proposed different measures to compute textual entailment between two terms allowing us to hopefully select appropriate keywords from thesauri to expand documents or queries automatically.
Socioeconomic status influences physical fitness in European adolescents independently of body fat and physical activity: the HELENA study.

INTRODUCTION The influence of socioeconomic status on health-related fitness is not clear. AIM To examine the influence of socioeconomic status on health-related fitness in adolescents. METHODS A total of 3,259 adolescents (15.0 +/- 1.3 y) from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study (HELENA-CSS) participated in the study. Socioeconomic status was assessed by the family affluence scale (FAS). Speed-agility, muscular strength and cardiorespiratory fitness were assessed. Covariates included total body fat, physical activity and pubertal status. RESULTS Adolescents with high FAS had significantly higher fitness levels than their peers of lower FAS categories except for speed-agility and handgrip in boys. Overall, the associations observed presented a medium to large effect size. CONCLUSION These results suggest that socioeconomic status is positively associated with physical fitness in European adolescents independently of total body fat and habitual physical activity.
Development of Diversified Methods for Chemical Modification of the 5,6-Double Bond of Uracil Derivatives Depending on Active Methylene Compounds

The reaction of 5-halogenouracil and uridine derivatives 1 and 7 with active methylene compounds under basic conditions produced diverse and selective C-C bond formation products by virtue of the nature of the carbanions. Three different types of reactions such as the regioselective C-C bond formation at the 5- and 6-positions of uracil and uridine derivatives (products 2, 5, 8, 17, 20 and 21), and the formation of fused heterocycle derivatives 2,4-diazabicyclo[4.1. 0]heptane (15) and 2,4-diazabicyclo-[4.1. 0]nonane (16) via dual C-C bond formations at both the 5- and 6-positions were due to the different active methylene compounds used as reagents.
A 45% Drain Efficiency, -50dBc ACLR GaN HEMT Class-E Amplifier with DPD for W-CDMA Base Station

A 10W GaN HEMT class-E amplifier for W-CDMA base station is demonstrated in this paper. We first demonstrate that a low pass type class-E circuit has quite similar performance to widely used series L-C resonance class-E circuit by simulating voltage and current waveforms with 50V operation GaN HEMT at 2.1GHz. We achieved measurement results; drain efficiency of 82%, CW output power of 11W and linear gain of 19.5dB at 2.1GHz and 50V drain bias operation with a simple low pass class-E circuit. And ACLR of -50dBc was obtained with 45% drain efficiency under 2-carrier W-CDMA , 7.8dB PAR (0.01%) signals, by using digital pre-distortion (DPD) operation
The effects of transformer connection type on voltage and current unbalance propagation

Unbalanced line currents cause unbalanced voltage drops on the three phases of the supply system. Consequently, the voltage system within the supply network will become unbalanced. Voltage unbalance has different detrimental effects in electrical power systems, such as the growth of losses in drive systems and adjustable speed drives, supplementary heating, line-current unbalance, derating, torque pulsation, mechanical stresses, etc. This paper makes an effort to have a comprehensive analysis of the effects of different connection types of three phase transformers on voltage unbalance propagation in distribution networks. The indices of voltage unbalance factor (VUF) and current unbalance factor (IUF) are used in this paper to evaluate the unbalance propagation. These indices are acquired utilizing symmetrical component theory on three phase voltages and currents earned through the system impedance matrix.
cAMP-Dependent Long-Term Potentiation of Nitric Oxide Release from Cerebellar Parallel Fibers in Rats

Nitric Oxide (NO) is released from parallel fibers (PFs) after PF stimulation. NO–cGMP signaling is essential for long-term depression (LTD) in cerebellar PF–Purkinje cell synapses, which also exhibit presynaptic long-term potentiation (LTP) after tetanic PF stimulation. This LTP is dependent on cAMP but not NO–cGMP signaling. In this study, we analyzed long-term changes of NO release from PFs in rat cerebellar slices using electrochemical NO probes. Repetitive PF stimulation at 10 Hz for 2 sec elicited a transient increase in NO concentration (2.2 ± 0.1 nm; mean ± SEM;n = 116). This NO release exhibited long-term potentiation (LTPNO) by 36 ± 3% (n = 15) after tetanic PF stimulation. Induction of LTPNO was not affected by Glu receptor antagonists. NO release from PFs was also potentiated by l-Arg (ARG) (100 μm), forskolin (50 μm), and 8-bromo-cAMP (Br-cAMP) (1 mm) but not by 1,9-dideoxyforskolin (50 μm), a biologically inactive analog of forskolin. The potentiation induced by forskolin was significantly suppressed by H89 (10 μm), a blocker of cAMP-dependent protein kinase. The potentiation induced by forskolin, but not that induced by Arg, interfered with LTPNO. H89 (10 μm) and KT5720 (1 μm), another blocker of cAMP-dependent protein kinase, but not KT5823 (300 nm), a blocker of cGMP-dependent protein kinase, significantly suppressed LTPNO. These data indicate that neural NO release is under activity-dependent control, just as synaptic transmitter release is. LTPNO might play a role in cross talk between presynaptic and postsynaptic plasticity by facilitating NO–cGMP-dependent postsynaptic LTD after induction of cAMP-dependent presynaptic LTP and LTPNO.
Canonical Barriers on Convex Cones

On the interior of a regular convex cone K in n -dimensional real space there exist two canonical Hessian metrics, the one generated by the logarithm of the characteristic function, and the Cheng-Yau metric. The former is associated with a self-concordant logarithmically homogeneous barrier on K , the universal barrier. It is invariant with respect to the unimodular automorphism subgroup of K and is compatible with the operation of taking product cones, but in general it does not behave well under duality. Here we introduce a barrier associated with the Cheng-Yau metric, the canonical barrier. It shares with the universal barrier the invariance, existence, and uniqueness properties and is compatible with the operation of taking product cones, but in addition is well behaved under duality. The canonical barrier can be characterized as the convex solution of the partial differential equation log det F ” = 2 F that tends to infinity as the argument tends to the boundary of K . Its barrier parameter does not exceed the dimension n of the cone. On homogeneous cones both barriers essentially coincide.
Temperature cycles drive Drosophila circadian oscillation in constant light that otherwise induces behavioural arrhythmicity

The fruit fly, Drosophila melanogaster, shows a clear circadian locomotor rhythm in light cycles and constant darkness. Although the rhythm disappears in constant light, we found that temperature cycles drive the circadian rhythm both in locomotor activity and molecular abundance of PERIOD (PER) and TIMELESS (TIM). The thermoperiodically induced locomotor rhythm entailed an anticipatory activity at the late thermophase, which required several transient cycles to establish a steady‐state entrainment, suggesting that the rhythm is endogenous and driven by a circadian clock. Western blot analysis revealed that PER and TIM increased during the cryophase, peaking at the middle to late cryophase. PER was also cyclically expressed under the temperature cycle in the known per‐expressing neurons, i.e. so‐called lateral (LNs) and dorsal neurons (DNs), and two pairs of cells (LPNs) that were located in the lateral posterior protocerebrum. It is thus suggested that the temperature cycle induces the cycling of PER and TIM either by blocking somewhere in the photic entrainment pathway during the cryophase or temporally activating their translation to sufficient protein levels to drive a circadian oscillation. In flies lacking pigment‐dispersing factor (PDF) or PDF‐expressing cells, the anticipatory activity was relatively dispersed. disco2 mutant flies lacking the lateral neurons still showed an anticipatory activity, but with dispersed activity. These behavioural results suggest that not only LNs but also DNs and LPNs can, at least, partially participate in regulating the thermoperiodically induced rhythm.
Computing ALCH-Subsumption Modules Using Uniform Interpolation

We investigate how minimal subsumption modules can be extracted using methods for uniform interpolation and forgetting. Given an ontology and a signature of concept and role names, a subsumption module is a subset of the ontology that preserves all logical entailments that can be expressed in the description logic of the ontology using only terms in the specified signature. As such, they are useful for ontology reuse and ontology analysis. While there exists a range of methods for computing or approximating minimal modules for a range of module types, we are not aware of a practical, implemented method for computing minimal subsumption modules in description logics beyond ELH. In this paper, we present a method that uses uniform interpolation/forgetting to compute subsumption modules in ALCH, and which under certain conditions guarantees minimality of the extracted modules. As a side product , our method computes a so-called LK subsumption module, which over-approximates the union of all minimal subsumption modules, and as such may already have applications of its own. We further present an initial evaluation of this method on a varied corpus of ontologies.
Extreme ecological response of a seabird community to unprecedented sea ice cover

Climate change has been predicted to reduce Antarctic sea ice but, instead, sea ice surrounding Antarctica has expanded over the past 30 years, albeit with contrasted regional changes. Here we report a recent extreme event in sea ice conditions in East Antarctica and investigate its consequences on a seabird community. In early 2014, the Dumont d'Urville Sea experienced the highest magnitude sea ice cover (76.8%) event on record (1982–2013: range 11.3–65.3%; mean±95% confidence interval: 27.7% (23.1–32.2%)). Catastrophic effects were detected in the breeding output of all sympatric seabird species, with a total failure for two species. These results provide a new view crucial to predictive models of species abundance and distribution as to how extreme sea ice events might impact an entire community of top predators in polar marine ecosystems in a context of expanding sea ice in eastern Antarctica.
Community Discovery on Multi-View Social Networks via Joint Regularized Nonnegative Matrix Triple Factorization

SUMMARY In multi-view social networks ﬁeld, a ﬂexible Nonnega-tive Matrix Factorization (NMF) based framework is proposed which integrates multi-view relation data and feature data for community discovery. Beneﬁt with a relaxed pairwise regularization and a novel orthogonal regularization, it outperforms the-state-of-art algorithms on ﬁve real-world datasets in terms of accuracy and NMI.
SOME MATHEMATICAL FOUNDATIONS OF CRYPTOGRAPHY

This paper introduces three mathematical methods of sharing encrypted information: the Pohlig-Hellman Key Exchange and the ElGamal and RSA cryptosystems. These systems are based on the hardness of integer factorization and the Discrete Logarithm Problem. Definitions of these problems and attacks against these cryptosystems are discussed. This paper assumes no prior experience with cryptography or modular arithmetic and builds up from basic definitions.
Sporotrichal Tenosynovitis Diagnosed Helpfully by Musculoskeletal Ultrasonography

A 72-year-old man presented with persistent oligoarthritis and positive results for rheumatoid factor and was suspected of having rheumatoid arthritis (RA). However, the musculoskeletal ultrasonography (MSUS) findings were not consistent with those of typical RA. He had undergone surgery for carpal tunnel syndrome, which allowed both histopathological and microbiological examinations to be performed. A synovial tissue culture was positive for Sporothrix schenckii, and he was diagnosed with sporotrichal tenosynovitis. He received anti-fungal therapy, and the sporotrichal tenosynovitis resolved. This case suggests that MSUS is a useful modality, and sporotrichal tenosynovitis, though rare, should be considered in the differential diagnosis of RA.
Extrapolation Practice for Ecotoxicological Effect Characterization of Chemicals

Extrapolation in the Context of Criteria Setting and Risk Assessment, K.R. Solomon, T.C M. Brock, D. De Zwart, S. Dyer, L. Posthuma, S. Richards, H. Sanderson, P. Sibley, and P.J. van den Brink Matrix and Media Extrapolation, D. De Zwart, A. Warne, V. Forbes, L. Posthuma, W. Peijnenburg, and D. van de Meent (Q)SAR and Extrapolation, H. Sanderson, S. Dyer, and V.J. Nabholz Extrapolation of Effects Measures Across Levels of Biological Organization in Ecological Risk Assessment, P.J. van den Brink, P.K. Sibley, H.T. Ratte, D.J. Baird, J.V. Nabholz, and H. Sanderson Mixture Extrapolation Approaches, L. Posthuma, S. Richards, D.De Zwart, S. Dyer, P. Sibley, C. Hickey, and R. Altenburger Temporal Extrapolation in Ecological Effect Assessment of Chemicals, T.C M. Brock, K. Solomon, R. van Wijngaarden, and L. Maltby Spatial Extrapolation in Ecological Effect Assessment of Chemicals, T.C M. Brock, L. Maltby, C. W. Hickey, J. Chapman, and K. Solomon Conclusions, K.R. Solomon, T.C. M. Brock, D. De Zwart, S. Dyer, L. Posthuma, S. Richards, H. Sanderson, P. Sibley, and P.J. van den Brink Glossary Guidance on the Application of Extrapolation Methods in Ecological Exposure and Effects Characterization of Chemicals, L. Posthuma, D. De Zwart, K. Solomon, and T.C. M. Brock References Index
Design and measurement of a high speed 2.5 Gbits/sec laser drive

In this paper the design and measurement of a 2.5 V CMOS laser drive are presented, which is able to drive Fabry-Perot as well as VCSEL laser diodes at a bit rate of 2.5 Gbits/sec. The inputs of the circuit are PECL compliant. The circuit has a programmable bias current ranging from 0 to 60 mA and a programmable modulation current ranging from 0 to 30 mA. The design is realised in UMC 0.25U CMOS