Miracle-dz/UniFAR-FTUs huggingface dataset:
Annexin IV is Differentially Expressed in Clear Cell Carcinoma of the Ovary

Objective: To investigate the genes that were differentially expressed between clear cell carcinoma (CCC) and serous carcinoma (SAC) of the ovary with complementary DNA microarray. Methods: Complementary DNA microarray was carried out in 8 CCCs and 8 SACs of the ovary. Differentially expressed genes were identified and verified by real-time polymerase chain reaction. The expression of the protein was also verified with immunohistochemistry and Western blot in cells and tissues of ovarian CCC. Results: Comparison of the gene expression profiling identified 21 genes with more than 2-fold different expression between CCC and SAC of the ovary. The up-regulated and down-regulated genes were 9 and 12, respectively. The verification of Annexin IV in the cell line and tissues was in accordance with the result of the microarray. Conclusions: The complementary DNA microarray technique is a feasible way to explore the difference of the gene expression profiling between the 2 types of ovarian carcinoma. The overexpression of Annexin IV may be an ovarian CCC-specific molecular marker. Abbreviations: CCC- clear cell carcinoma, SAC- serous carcinoma, PCR- polymerase chain reaction, RT-PCR- reverse transcriptase PCR, ABCF2- ATP-binding cassette, sub-family F- member 2, HNF-1b- hepatocyte nuclear factor 1β
Extending LP Optimizer Functionality for Model Predictive Control

The subject of this paper is linear programming (LP) optimizer application with Model Predictive Control (MPC). This extremely successful merger of two major control technologies is enabled as a consequence of the MPC feature of providing a prediction of the process outputs up to steady state, thus creating the required conditions for optimizer operation. However, the standard LP algorithm which finds a solution only within acceptable limits, does not perform properly when some of the predicted process outputs are out of limits. On the other hand, the optimizer applied with the MPC controller must always find a solution and thus there is a need to extend the original optimization formulation. This paper presents robust and reliable ways of handling optimized process outputs that are out of the limits. The technique is based on the priority structure, penalizing slack variables, and redefining the constraint model. In addition LP functionality is extended by defining one- or two-sided ranges around the control variables set points and preferred settling values for the manipulating variables. This technique has been implemented in an industrial control system and will be presented interactively by simulating the optimization and control of a distillation column.
Assessment of Shape Variation of the Levator Ani With Optimal Scan Planning and Statistical Shape Modeling

Objective: To capture 3D shape variation of the levator ani during straining with open access MR imaging. Methods: Optimal scan-planning based on statistical shape modeling is developed for recovering the entire 3D structure of the levator ani from a limited number of 2D imaging planes. Statistical shape modeling ensures optimum material correspondence, and Subspace Reprojection is used to identify the optimum orientation of the imaging plans. The accuracy of the method in using limited 2D imaging planes to instantiate the dynamic structure of the levator ani is assessed with data acquired from 10 asymptomatic subjects. Results: Leave-one-out analysis was performed whereby a model based on a training set consisting of all but one surface was used to instantiate the dynamic surface structure from the corresponding optimal planes. The mean surface distance error for the proposed Subspace Reprojection method is 3.989 ± 0.790 mm, which is significantly smaller than other approaches. Conclusions: Surfaces of the levator ani may be instantiated using a limited number of imaging planes as well as a statistical shape model based on a training set of subjects. The proposed technique offers a new way forward for studying dynamic shape changes of 3D structures where complete volumetric imaging is prohibited by the inherent temporal resolution of the scanning technique.
Cultural differences in emotion regulation during self-reflection on negative personal experiences

Reflecting on negative personal experiences has implications for mood that may vary as a function of specific domains (e.g., achievement vs. interpersonal) and cultural orientation (e.g., interdependence vs. independence). This study investigated cultural differences in the social-cognitive and affective processes undertaken as Easterners and Westerners reflected on negative interpersonal and performance experiences. One hundred Asian Americans and 92 European-American college students were randomly assigned to one of three conditions: interpersonal rejection, achievement failure, or a control condition. Results revealed that Asian Americans experienced greater distress than European Americans after self-reflecting over a failed interpersonal experience, suggesting cultural sensitivity in the relational domain. Consistent with theoretical predictions, analysis of the social cognitive and affective processes that participants engaged in during self-reflection provided some evidence that self-enhancement may buffer distress for European Americans, while emotion suppression may be adaptive for Asian Americans.
Laser-free slow atom source

A slow atom source, which does not rely on lasers, has been developed and characterized. The device, acting as an atomic low-pass velocity filter, utilizes permanent magnets to passively select the slow atoms present in a thermal atomic beam. Slow atoms are guided along a curved, conduction-limited tube by an octupole magnetic field, while fast atoms, unable to follow the curved trajectory, strike the tube wall and are removed from the beam. The performance of the device is demonstrated by loading a magneto-optical trap. Approximately 2310 lithium atoms are loaded with a rate of ;6310 atoms/s, while maintaining a background gas pressure of ;10 torr. This loading technique provides an exceptionally simple, economical, and robust alternative to laser cooling methods. @S1050-2947~99! 00411-4#
Loss of Monetary Policy Autonomy and Public Attitude toward Monetary Union

The paper investigates the public's attitude towards monetary union arrangements associated with different levels of monetary policy autonomy. The results indicate that support for monetary union declines significantly with expected loss of autonomy. Survey data from Kenya shows that public support for the proposed East African Community monetary union is highest in an arrangement where the country assumes the role of anchor and lowest where the country assumes a client role. A more favorable appraisal of the effects of monetary union by the public increases the likelihood of voting for a multilateral monetary union but decreases the likelihood of voting for a client role in a unilateral dollarization arrangement. This suggests that for countries without clear differences in monetary policy credibility, but with political systems where voter preferences matter, multilateral monetary union would be a more stable arrangement.
Edge detection of mineral water bottle image based on NSCT and Canny algorithm

Some edge detection algorithms based on spatial and wavelet technology can detect image edge of limited direction effectively. Since these algorithms haven't fully utilized field information, there would be great error around the complex edge area in the detection results. To solve such kind of problem, a novel edge detection algorithm by combining nonsub- sampled contourlet transform (NSCT) and Canny algorithm is proposed in this paper. Simulation results are displayed to prove that this algorithm can extract more image edge details than Canny algorithm and it also has good continuity and robustness.
A 2 GHz 2 Mb/s Semi-Digital $2^{+}$-Point Modulator With Separate FIR-Embedded 1-Bit DCO Modulation in 0.18 $\mu$ m CMOS

A 2 GHz two-point modulator which has a separate high-pass control for DCO modulation is implemented in 0.18 μm CMOS. The proposed modulator with the two-path DCO modulation enables a flexible gain partition for the high-pass and low-pass modulation paths within the DCO and relaxes the DCO nonlinearity with 1-b ΔΣ modulation and embedded finite-impulse response (FIR) filtering. A semi-digital ΔΣ PLL with another FIR filtering in the low-pass modulation enhances PLL linearity with a hybrid loop control. The proposed semi-digital modulator achieves 2.03% RMS EVM with 2 Mb/s GFSK modulation, -132 dBc/Hz phase noise at 3 MHz offset, and -80 dBc reference spur.
METODE PENDIDIKAN ANAK DALAM ISLAM MENURUT ABDULLAH NASHIH ULWAN DALAM KITAB TARBIYATUL AWLAD FIL ISLAM

Penelitian ini bertujuan untuk mengetahui metode pendidikan anak dalam Islam menurut Abdullah Nashih Ulwan dalam kitab Tarbiyatul Awlad Fil Islam dan untuk mengetahui relevansinya dengan konteks pendidikan saat ini. Metode yang digunakan dalam penelitian ini adalah dengan menggunakan pendekatan kualitatif jenis studi pustaka dengan menggunakan sumber pokok kitab Tarbiyatul Awlad Fil Islam karangan Abdullah Nasih Ulwan. Hasil penelitian ini menunjukkan bahwa metode pendidikan anak menurut Abdullah Nasih Ulwan adalah melalui keteladanan, pembiasaan, pemberian nasehat, pengawasan dan pemberian hukuman. Sedangkan relevansinya terhadap pendidikan saat ini adalah kitab ini mendapat sambutan baik disertai pujian yang tulus dari para guru, ulama dan pendidik bahkan ada juga dari pakar-pakar, sastrawan dan para dai yang berkoresponden terhadap penulis. Selain itu setiap pembahasannya selalu didasarkan pada bukti atau dalil Alquran, Hadis maupun pendapat ulama. Kata Kunci: Metode, pendidikan, anak
Visceral Fat and Cardiovascular Risk Factors in Chinese NIDDM Patients

OBJECTIVE The interrelations between obesity, glucose intolerance, hypertension, dyslipidemia, and insulin resistance are well recognized. These relationships are of particular interest in Hong Kong's Chinese population, in whom increasing affluence has coincided with a marked increase in the prevalence of NIDDM. We designed a pilot study to examine the relationships between visceral fat and cardiovascular risk factors in Chinese NIDDM patients. RESEARCH DESIGN AND METHODS We studied 21 Chinese NIDDM patients whose visceral fat was quantified by magnetic resonance imaging. Cardiovascular risk factors including plasma lipids and 24-h ambulatory blood pressure (BP) were measured. In addition, insulin resistance was determined by a short insulin tolerance test (SITT). RESULTS Increased visceral adiposity was significantly correlated with plasma triglycerides (r = 0.63, P = 0.004), the total cholesterol/HDL cholesterol ratio (r = 0.61, P = 0.008), the urinary albumin/creatinine ratio (r = 0.49, P = 0.04), and decreased insulin sensitivity as measured by the SITT (r = 0.47, P = 0.03). When the data were analyzed by tertiles, increasing visceral fat area was associated with higher plasma triglycerides, lower HDL cholesterol, and a smaller plasma glucose decrement during the SITT. In addition, the diurnal rhythm in BP and heart rate tended to be best preserved in those with the least visceral obesity. CONCLUSIONS This pilot study demonstrates that visceral fat accumulation is associated with dyslipidemia, hypertension, insulin resistance, and albuminuria in Chinese patients with NIDDM.
Effect of Methicillin-Resistant Staphylococcus aureus Colonization in the Neonatal Intensive Care Unit on Total Hospital Cost

The rate of methicillin-resistant Staphylococcus aureus (MRSA) infection is increasing in neonatal intensive care units. We determined the economic impact of isolating and cohorting MRSA-colonized neonates on total hospital cost at a 49-bed, level III-IV neonatal intensive care unit.
Detection of caseinophosphopeptides in the distal ileostomy fluid of human subjects

Caseinophosphopeptides (CPP) were detected for the first time in ileostomy fluid, collected at 2 h intervals for 10 h post milk and CPP ingestion, from human volunteers with an ileostomy. The level of CPP present in ileostomy fluid obtained from milk-fed volunteers was markedly higher than that from volunteers fed with selected CPP preparations. The findings are based on HPLC analysis in combination with peptide-bound P determination, thin-layer electrophoresis and amino acid analysis, together with ELISA studies using polyclonal antibodies raised against a set of CPP to detect immunoreactive CPP in ileostomy fluid. These procedures allowed the detection of nm concentrations of CPP. CPP, which can be released during intestinal digestion, may function as bioactive constituents and carriers for different minerals, especially Ca, and may be used as ingredients in functional foods or pharmaceutical preparations.
Fully integrated active CMOS vector modulator for 802.11a compliant diversity transceivers

In this paper, a CMOS vector modulator designed for smart antenna arrays at 5.5 GHz is presented. A quadrature all pass filter and sign select switches yield two orthogonal signal paths. Two variable gain amplifiers with strongly reduced phase shift of only ±6 ° are used to weight these paths. It has a phase control range of 360 ° and a gain range of −20 dB to 2.8 dB. The input-referred IP3 is −7 dBm at maximum gain. The current drawn from a 1.5 V supply amounts 12 mA. Using a 180 nm technology, the chip core area amounts 1.2×0.8 mm².
medicare and the nurse: The Physician as a Member of the Home Healthcare Team

The physician is a vital member of the home healthcare team. Based on the Medicare legislation and regulations. The physician's participation is required for patient care and agency reimbursement. The home health care nurse is the important link between the patient and the physician. The compliance with, and sharing of, information related to the clinical, administrative, legislative and regulatory aspects of care benefits the patient, family, physician, nurse and the home health agency.
Substrate choice of membrane‐type 1 matrix metalloproteinase is dictated by tissue inhibitor of metalloproteinase‐2 levels

Although tissue inhibitor of metalloproteinase‐2 (TIMP‐2) is known to be not only an inhibitor of matrix metalloproteinases (MMP) but also a cofactor for membrane‐type 1 MMP (MT1‐MMP)‐mediated MMP‐2 activation, it is still unclear how TIMP‐2 regulates MMP‐2 activation and cleavage of substrates by MT1‐MMP. In the present study we examined the levels of cell‐surface MT1‐MMP, MMP‐2 activation and cleavage of MT1‐MMP substrates in 293T cells transfected with the MT1‐MMP and TIMP‐2 genes. Co‐expression of TIMP‐2 at an appropriate level increased the level of cell‐surface MT1‐MMP, both the TIMP‐2‐bound and free forms, and generated processed MMP‐2 with gelatin‐degrading activity. In contrast, MT1‐MMP substrates testican‐1 and syndecan‐1 were cleaved by the cells expressing MT1‐MMP, which was inhibited by TIMP‐2 even at levels that stimulate MMP‐2 activation. These results suggest that TIMP‐2 environment determines MT1‐MMP substrate choice between direct cleavage of its own substrates and MMP‐2 activation. (Cancer Sci 2007; 98: 563–568)
Effects of steroids and retinoids on wound healing.

HYPOTHESIS Anti-inflammatory corticosteroids significantly impair wound healing. Retinoids partially, but significantly, reverse this effect. Little is known about the mechanism of steroid retardation or retinoid reversal. We hypothesized that corticosteroids lower transforming growth factor-beta (TGF-beta) and insulin-like growth factor-I (IGF-I) levels and tissue deposition in wounds and that retinoids stimulate corticosteroid-impaired TGF-beta and IGF-I release and collagen production. DESIGN Randomized controlled trial. SETTING Wound healing research laboratory. PARTICIPANTS Animal study. INTERVENTIONS Four wire mesh wound cylinders were implanted subcutaneously into the backs of 72 male Sprague-Dawley rats. Wound healing was impaired by a single subcutaneous injection of 6 mg of methylprednisolone acetate (Depo-Medrol). Two preparations of retinoids were used in separate experiments: all-trans-retinoic acid and 9-cis-retinoic acid that were fed orally. MAIN OUTCOME MEASURES Hydroxyproline content was measured in the healing tissue and TGF-beta and IGF-I levels were analyzed in the wound fluid. RESULTS Methylprednisolone treatment significantly decreased TGF-beta and IGF-I levels in the wound fluid and hydroxyproline content in the tissue (P<.05). Oral all-trans- and 9-cis-retinoic acid partially reversed the TGF-beta and IGF-I decrease and significantly increased hydroxyproline content toward normal levels (P<.05). Oral all-trans-retinoic acid enhanced collagen deposition, TGF-beta and IGF-I levels over normal chow fed control animals (P<.05). CONCLUSIONS Steroids and retinoids have antagonistic effects on growth factors and collagen deposition in wound healing. These effects can be relevant for treatment options in a clinical setting.
Identification of PK-A phosphorylation sites in the carboxyl terminus of L-type calcium channel alpha 1 subunits.

Full length L-type calcium channel alpha 1 subunits are rapidly phosphorylated by protein kinase A (PK-A) in vitro and in vivo at sites located in their long carboxyl terminal tails. In skeletal muscle, heart, and brain the majority of biochemically isolated alpha 1 subunits lacks these phosphorylation sites due to posttranslational proteolytic processing. Truncation may therefore modify the regulation of channel activity by PK-A. We combined site-directed mutagenesis and heterologous expression to investigate the extent to which putative cAMP-dependent phosphorylation sites in the C-terminus of alpha 1 subunits from skeletal muscle, heart, and brain are phosphorylated in vitro. The full length size form of wild-type and mutant calcium channel alpha 1 subunits was obtained at high yield after heterologous expression in Saccharomyces cerevisiae. Like in fetal rabbit myotubes [Rotman, E.I. , et al. (1995) J. Biol. Chem. 270, 16371-16377], the rabbit skeletal muscle alpha 1 C-terminus was phosphorylated at serine residues 1757 and 1854. In the carboxyl terminus of alpha 1S from carp skeletal muscle and alpha 1C from rabbit heart a single serine residue was phosphorylated by PK-A in vitro. The C-terminus of alpha 1D was phosphorylated at more than one site. Employing deletion mutants, most of the phosphorylation ( > 70%) was found to occur between amino acid residues 1805 and 2072. Serine 1743 was identified as additional phosphorylation site in alpha 1D. We conclude that in class S and C calcium channels the most C-terminal phosphorylation sites are substrate for PK-A in vitro, whereas in class D calcium channels phosphorylation also occurs at a site which is likely to be retained even after posttranslational truncation.
Molecular structure and spectroscopic characterization of Metformin with experimental techniques and DFT quantum chemical calculations

Metformin is one of the important antidiabetic drugs to treat non – insulin dependent diabetes mellitus. A complete vibrational assignment and analysis of the fundamental modes of Metformin was carried out using FT-IR, FT-Raman and Quantum Chemical studies. The observed vibrational data were compared with the wave numbers derived theoretically. Thermodynamic properties like entropy, heat capacity and enthalpy have been calculated for the molecule. HOMO, LUMO energy gap has been calculated, the intra-molecular contacts have been interpreted using natural bond orbital (NBO) and Natural Localized Molecular Orbital (NLMO) analysis. Finally the Mulliken Population Analysis on atomic charges of the title compound has been calculated. The B3LYP/6-311++G (d, p) based NMR calculation procedure was also done. The NLO properties of the molecule have also been studied. It was used to assign the 13C and 1 H NMR chemical shift of Metformin. The results of the calculations were applied to simulated spectra of the title compound which show excellent agreement with observed spectra.
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)formamide

In the title compound, C12H13N3O2, the dihedral angle between the pyrazole and benzene rings is 50.0 (3)°. In the crystal, molecules are linked by intermolecular N—H⋯O hydrogen bonds to form a three-dimensional network. Two weak C—H⋯π interactions reinforce the crystal packing.
Weed Seeds Recognition Using Color PCA

In this paper, a novel approach for the recognition of weed seeds, known as color Principal Component Analysis (PCA), is presented. This experiment involves two steps: dimensionality reduction with color PCA and classification. In dimensionality reduction part, Color is used as an important element to identify weed seeds. To perform the recognition of color weed seeds images, we use the features of a 3D color tensor to generate vector spaces, and then color PCA is used to map the high dimensional spaces into low dimensional subspace and extract features. In classification part, minimum Euclidean distance classifier is used to recognize different weed seeds. Experimental results demonstrate that the representation of color PCA is superior significantly as expected and gains much higher recognition rates, amounting to 80.8%, which is 4.4% higher than those of traditional PCA.
Cell-Specific Transcriptional Regulation of Follicle-Stimulating Hormone-β by Activin and Gonadotropin-Releasing Hormone in the LβT2 Pituitary Gonadotrope Cell Model.

FSH is secreted by gonadotropes of the anterior pituitary and plays a crucial role in mammalian reproduction. However, little is known about FSH gene regulation due to the lack of a gonadotrope cell line that synthesizes FSH. The LbetaT2 mouse pituitary cell line, isolated by targeted tumorigenesis in transgenic mice, has the characteristics of a mature gonadotrope, including expression of GnRH receptor, steroidogenic factor 1, and both the alpha- and beta-subunits of LH, but was thought not to express FSH. Using RT-PCR, we show that these cells synthesize FSH beta- subunit messenger RNA, which is induced by activin and inhibited by follistatin. Furthermore, in transient transfections an ovine FSHbeta 5'-regulatory region (5.5 kb) confers LbetaT2 cell-specific expression to a reporter gene compared with other pituitary and nonpituitary cell lines. This FSHbeta regulatory region responds to activin specifically in LbetaT2 cells, an effect that is blocked by follistatin. The LHbeta, alpha-subunit, and GnRH receptor regulatory regions are induced by activin and blocked by follistatin. Furthermore, LbetaT2 cells express the components of the activin system, and addition of follistatin alone reduces FSHbeta gene expression, demonstrating that an endogenous activin autocrine loop regulates FSH in these cells. In addition, GnRH stimulates both the FSHbeta and LHbeta regulatory regions, specifically in LbetaT2 cells. Surprisingly, GnRH induction is reduced by follistatin, suggesting its dependence on endogenous activin. As the mouse GnRH receptor promoter is inhibited by follistatin, reduction of GnRH receptor levels might be one mechanism by which follistatin interferes with GnRH induction of gonadotropin genes. In summary, LbetaT2 cells exhibit the characteristics of fully differentiated gonadotropes, including the expression of LH, FSH, GnRH receptor, and components of the activin/follistatin system, as well as display the appropriate responses to activin and GNRH: