Miracle-dz/UniFAR-FTUs huggingface dataset:
The hepatic activities of 1-carbon enzymes during the chronic administration of diethylnitrosamine, 2-acetylaminofluorene, and n,n-dimethyl-4-aminoazobenzene to rats.

Summary The levels of seven enzymes involved in the metabolism of 1-carbon compounds and their precursors were investigated in the cytoplasmic fractions of the livers of rats receiving the hepatocarcinogens diethylnitrosamine, 2-acetylaminofluorene, and N,N -dimethyl-4-aminoazobenzene for 1 to 5 weeks. The enzymes studied included serine hydroxymethylase, dihydrofolate reductase (H 2 -folate reductase), formylase, methylene-H 4 -folate dehydrogenase, formiminoglutamic acid transferase, urocanase, and histidase. The levels of formiminoglutamic acid transferase and urocanase were found to be significantly lower in the livers of rats treated with each of the hepatocarcinogens for 3 to 5 weeks than in the livers of corresponding control rats. The hepatic activities of formylase, methylene-H 4 -folate dehydrogenase, and histidase were decreased during the chronic administration of diethylnitrosamine and 2-acetylaminofluorene but not by the chronic feeding of N,N -dimethyl-4-aminoazobenzene; however, the low-protein, low-riboflavin diet used as a control diet in the aminoazo dye experiments also led to low hepatic levels of these 3 enzymes. Administration of diethylnitrosamine and N,N -dimethyl-4-aminoazobenzene to rats for 3 weeks led to a slight but significant increase in the hepatic levels of H 2 -folate reductase, in comparison to the corresponding levels in livers of control rats; the feeding of 2-acetylaminofluorene appeared to have no significant effect on hepatic H 2 -folate reductase activity. None of the carcinogens investigated appeared to have a significant effect on the hepatic levels of serine hydroxymethylase. The administration of a choline-deficient diet to weanling rats for 5 weeks produced significant decreases in the hepatic levels of formylase, methylene-H 4 -folate dehydrogenase, histidase, urocanase, and formimino-glutamic acid transferase; the choline deficiency produced no effect on the hepatic levels of serine hydroxymethylase and H 2 -folate reductase. The results indicate that chronic administration to rats of either a hepatocarcinogenic or methyl-deficient regimen decreased the hepatic levels of five enzymes involved in the synthesis of the formyl derivatives of H 4 -folate.
Increased Cellular Proliferation and Inflammatory Cytokines in Tonsils Derived From Children With Obstructive Sleep Apnea

Adenotonsillar hypertrophy is the major pathophysiological mechanism underlying obstructive sleep apnea (OSA) and recurrent tonsillitis (RI) in children. The increased expression of various mediators of the inflammatory response in tonsils of patients with OSA prompted our hypothesis that the enhanced local and systemic inflammation in children with OSA would promote tonsillar proliferation. Mixed cell cultures from tonsils recovered during adenotonsillectomy in children with OSA and RI were established, and proliferative rates were assessed. Cells were also cultured to determine the levels of proinflammatory cytokines and antioxidant protein levels and mRNA expression. Global cell proliferative rates from OSA tonsils were significantly higher than RI (p < 0.01), with CD3+, CD4+, and CD8+ cell proliferation being higher in OSA (p < 0.05). Moreover, proinflammatory cytokines, such as TNF-α, IL-6, and IL-1α, were highly expressed in OSA-derived tonsils. Furthermore, thioredoxin (TRX), an antioxidant protein, was also highly expressed in OSA tonsils at the mRNA and protein levels (p < 0.01). Thus, T cells are in a highly proliferative state in the tonsils of children with OSA and are associated with increased production of proinflammatory cytokines and TRX, when compared with children with RI.
Developing a Privacy Compliance Scale for IoT Health Applications

Internet of things (IoT) is intensely gaining popularity in the healthcare industry. Though these systems are ubiquitous, pervasive and seamless, an issue concerning consumers’ privacy remains debatable. There is an immaculate rise in terms of awareness amongst patients where data privacy is concerned. IoT-based health applications are more prone to privacy risks, and hence general privacy guidelines for health applications, in general, are not adequate. Often, privacy is oversighted, causing consumers to lose interest from using an application continuously. In this paper, we propose a compliance scale modelling the privacy principles for privacy-aware novel IoT-based health applications. We have conducted an analytical review of privacy guidelines to derive at the essential principles required to develop and measure privacy-aware IoT health applications after discarding irrelevant principles, extracting repeating core principles, and merging relevant principles. A quantitative survey was deployed to empirically evaluate the proposed scale to finalize the principles based on their significance. The proposed compliance scale presents essential privacy principles to adhere in the development of novel IoT health applications. The proposed compliance scale would be significant for policymakers and applications developers to measure, better understand and respect the privacy principles of consumers towards novel IoT-based health applications.
APLIKASI KLASIFIKASI PENERIMA KARTU INDONESIA SEHAT MENGGUNAKAN ALGORITMA NAÏVE BAYES CLASSIFIER

Along with the rapid development of information technology today, the cost to meet the needs of life increasingly high, this is triggered by the amount of budget issued by the government to solve economic problems in Indonesia, especially in terms of National Welfare Guarantee. Kartu Indonesia Sehat is a card issued by the government and managed by the Badan Penyelenggara Jaminan Sosial (BPJS) to alleviate the poor for health. Existing problems such as in the distribution of the card has not been on target because of the amount of data obtained so highly possible error happens in determining the recipient of Kartu Indonesia Sehat. The concept of data mining is considered to solve the problems faced in determining the recipient community or not the recipient of Kartu Indonesia Sehat. Classification methods are able to find models that distinguish the concepts or data classes, with the spesific goal of determining the class of an unknown object label. Therefore, the Naive Bayes algorithm could predict future opportunities based on prior experience by considering some variables such as age, last education, occupation, monthly income and dependents of children that will determine the final outcome of a decision. The result of this research is a system that will predict the people who will receive Kartu Indonesia Sehat so that the government will distribute the card accurately to the public and the acquired results from the test obtained an average accuracy rate of 94.78%, 98.86% precision and 90.98% recall. DOI: https://doi.org/10.26905/jtmi.v4i1. 1870
An efficient test relaxation technique for combinational circuits based on critical path tracing

Reducing test data size is one of the major challenges in testing systems-on-a-chip. This can be achieved by test compaction and/or compression techniques. Having a partially specified or relaxed test set increases the effectiveness of compaction and compression techniques. In this paper, we propose a novel and efficient test relaxation technique for combinational circuits. It is based on critical path tracing and hence it may result in a reduction in the fault coverage. However, based on experimental results on ISCAS benchmark circuits, the drop in the fault coverage (if any) after relaxation is small for most of the circuits. The technique is faster than the brute-force test relaxation method by several orders of magnitude.
Using Household and Intrahousehold Data To Assess Food Insecurity: Evidence from Bangladesh

This report finds that many women and children in rural Bangladesh are undernourished in households in which their male head of household is adequately nourished, based on an analysis of the Bangladesh Integrated Household Survey. The survey covered household food consumption and expenditure for a given 7 days and individual-level consumption for a given 24 hours (2011 to 2012). Quantitative assessments of food secu­ rity for each type of data found that, if only household-level data were used, a signifi­ cant number of women and children were misclassified as receiving adequate nutrition because calories in a household previously were assumed to be equitably distributed. These findings suggest that intrahousehold data can contribute to the identification of undernourished populations, particularly women and children. Such identification, with the objective of improving nutritional status, is of particular interest to the U.S. Government’s interagency Feed the Future initiative.
FUNCTIONAL IMPAIRMENT IN MULTIPLE SCLEROSIS

The aim of this study was to analyse the physical fitness, functional parameters, fatigue, and independence in a group of patients with multiple sclerosis (MS), and to compare the results measured with applicable standards. We examined 35 MS patients with a clinically active form of MS (age 49.1 ± 10.0 years, 28 women, 7 men, mean duration of MS 15.4 ± 12.5 years, EDSS 3.0 ± 1.2) who participated in spiroergometric examination. All the patients underwent a symptom-limited spiroergometry on a bicycle (load 20 W increasing every 2 min) in order to evaluate the following parameters of functional capacity: maximal oxygen consumption (O2peak -ml O2,VO2peak.kg, -ml O2 . kg), maximal work load (Wpeak -watts, Wpeak .kg watts.kg). We measured the following haemodynamic parameters: heart rate (HR) and blood pressure (SBP and DBP). The data registered were compared with Czech standards (IBP standards – International Biological Program, Seliger et al., 1977). The patients were also tested for fatigue (MFIS questionnaire) and functional independence measure (FIM). The results showed a significant reduction of functional capacity, namely in the values of spiroergometry parameters (P<0.05, Wilcoxon paired) VO2peak (1432.9 ± 474.4 ml O2), VO2peak. kg (20.6 ± 5.9 ml O2.kg), Wpeak (89.0 ± 34.1 watts), and Wpeak . kg1 (1.29 ± 0.4 watts.kg) at the exercise peak. Correlations between clinical testing (EDSS), fatigue (MFIS), and spiroergometric data (Spearman coefficient) were obtained. The examined patients with MS have a low exercise tolerance and a rather low capacity of the transport system. Spiroergometric parameters depend on the degree of clinical disability and subjectively evaluated fatigue.
Advances in Brief Activation of the Abelson Tyrosine Kinase Activity Is Associated with Suppression of Apoptosis in Hemopoietic Cells 1

A chromosomal translocation uniquely associated with chronic myeloid leukemia leads to the formation of a chimeric gene, bcr-abl, on the Phil adelphia chromosome. The BRC-ABL protein displays an uncontrolled tyrosine kinase activity similar to that seen with the transforming onco gene of the Abelson murine leukemia (ABL) virus (\-abl). An interleukin 3 dependent cell line, IC.DP, has been transfected with a gene encoding a temperature sensitive v-ABL. In the absence of interleukin 3 at the re strictive temperature for ABL tyrosine kinase activity IC.DP cells died via apoptosis. At the permissive temperature ABL tyrosine kinase activity promoted IC.DP cell survival but not proliferation. ABL therefore can specifically suppress apoptosis.
The Stock Price Effect of Emerging From Bankruptcy and The Associated Effect of Switching Auditors Post Bankruptcy… An Industry Analysis

This study analyzes firms that emerge from Chapter 11 bankruptcy withspecific attention given to two groups; those that switch auditors post-bankruptcy,and those who retain previous auditors in a post-bankruptcy environment. In addition,further analysis is made to assess whether or not industry membership, along withpre or post SOX environment play a role in results.Results indicate that when the pre versus post SOX environment is assessed,a significant difference is noted in the sample firms. Post SOX firms emergingfrom Chapter 11 that switch auditors carry positive information content, therefore,investors tend to bid up the price of stock of these firms. Firms emerging fromChapter 11 in a post SOX environment that do not change auditors tend to conveynegative information content as their stock price is bid down by investors. Withrespect to a pre SOX environment, results indicate that investors do not behavesignificantly different whether the firms change auditors or not after emerging fromChapter 11. In both cases, there is a positive correlation between earnings responseand stock price.When attention turns to assessing individual industries in a post SOXenvironment, a positive correlation between earnings response and stock priceis seen across all industries evaluated when the firm emerging from Chapter 11switches auditors. Growth industry firms show the greatest stock price reaction toearnings. With respect to firms that do not switch auditors post-bankruptcy, resultsare mixed across industries. Most industries show a negative stock price reactionbut certain growth industries reflect a positive reaction. In a pre SOX environment,no significant industry difference is noted, either by firms that switch auditors orthose that do not switch. All pre SOX industry firms, on average, have a positivecorrelation between earnings response and stock price.
Independent mobility of people with visual impairment in the Central Business District of Harare: The physical threats, risks and hazards

The study sought to interrogate the nature of mobility difficulties experienced by people with visual impairment in the central business district of Harare. It also sought to determine the extent to which these difficulties negatively impacted on the independent mobility of people with visual impairment. Independent mobility for people with visual impairment in Harare is threatened by a number of obstacles. The study used a qualitative paradigm. The interpretive design was used in line with the paradigm selected.Interviews were used to gather data for this study.Opportunity sampling was deemed the best due to the nature of the study.The study found out that several dangers confronted people with visual impairment by way of pot holes, broken pavements,open drainage systems, and food stalls along thestreets. Vendors selling various wares on shop verandas and pavements,vehicles parked in undesignated areas were also a serious challenge. It was also found out that people with visual impairment themselves also had poor mobility skills. Absence of comprehensive by laws and lack of awareness and proper information dissemination strategies were also found out to be some of the challenges. The study recommended that city authorities should put in place stringent by laws to enhance effective independent mobility in the city.People with visual impairment needed proper mobility skills in order to move around in town. The use of modern technology such as laser canes was also recommended as a strategy to ease the mobility difficulties faced by people with visual impairment in the city.
Variations on a Theme: Cataloging Human DNA Sequence Variation

New methods for the discovery and scoring of single-nucleotide polymorphisms (SNPs) offer the potential for considerably improved methods for genetic analysis of complex biological phenomena, particularly common diseases. In this Policy Forum, the authors call for a publicly supported effort to discover a large number of SNPs and to place the information in public databases. Participation in this public effort by the private sector would be particularly desirable.
Impact of web personalization of online word of mouth on buyers' decision process: An experimental study

This study evaluates the impact of personalization of review summaries on consumer's buying decision and cognitive efforts. Following a quasi-experimental procedure we tested two hypotheses pertaining to online buyers' decision process. Our results show that personalized review summary significantly reduces the information processing effort and information requirements of those who received personalized review summaries as compared to those who did not. This study thus contributes to e-commerce literature on online buyer behavior and recommender systems strategy.
Coupling of Asymmetric Division to Polar Placement of Replication Origin Regions in Bacillus subtilis

ABSTRACT Entry into sporulation in Bacillus subtilis is characterized by the formation of a polar septum, which asymmetrically divides the developing cell into forespore (the smaller cell) and mother cell compartments, and by migration of replication origin regions to extreme opposite poles of the cell. Here we show that polar septation is closely correlated with movement of replication origins to the extreme poles of the cell. Replication origin regions were visualized by the use of a cassette of tandem copies oflacO that had been inserted in the chromosome near the origin of replication and decorated with green fluorescent protein-LacI. The results showed that extreme polar placement of replication origin regions is not under sporulation control and occurred in stationary phase under conditions under which entry into sporulation was prevented. On the other hand, the formation of a polar septum, which is under sporulation control, was almost invariably associated with the presence of a replication origin region in the forespore. Moreover, cells in which the polar placement of origin regions was perturbed by deletion of the gene (smc) for the structural maintenance of chromosomes (SMC) protein were impaired in polar division. A small proportion (≈1%) of the mutant cells were able to undergo asymmetric division, but the forespore compartment of these exceptional cells was generally observed to contain a replication origin region. Immunofluorescence microscopy experiments indicated that the block in polar division caused by the absence of SMC occurred at or prior to the step of bipolar Z-ring formation by the cell division protein FtsZ. A model is discussed in which polar division is under the dual control of sporulation and an event associated with the placement of a replication origin at the cell pole.
TIBCRPH: Traffic Infrastructure Based Cluster Routing Protocol with Handoff in VANET

Vehicular Ad Hoc network (VANET), is a hot topic that applying mobile Ad Hoc network (MANET) to ITS in recent years. Special environments and applications cause difficulties to the design of the routing protocols of VANET which can not use the exiting protocols well. Firstly, this paper introduces some concepts of VANET briefly, analyzes and compares some different kinds of existing routing protocols in VANET. Then, basing on the characteristics of the VANET, and utilizing the idea of cluster and handoff, a more efficient protocol is developed in this paper, which is dubbed Traffic Infrastructure Based Cluster Routing Protocol with Handoff (TIBCRPH). Finally, TIBCRPH is compared with other six typical routing protocols on node density and speed respectively by NS2. The results show that TIBCRPH performs better than some traditional routing protocols.
Degradation of an Fc‐fusion recombinant protein by host cell proteases: Identification of a CHO cathepsin D protease

A host‐cell‐related proteolytic activity was identified in a recombinant Fc‐fusion protein production process. This report describes the strategy applied to characterize and isolate the enzyme responsible for this degradation by combining cell culture investigation and dedicated analytical tools. After isolation and sequencing of the clipped fragment generated in post‐capture material, enzymatic activity was traced in different culture conditions, allowing identification of viable CHO cells as the source of protease. Inhibitors and pH screenings showed that the enzyme belongs to an aspartic protease family and is preferably active at acidic pH. The protease was isolated by purification on a pepstatin A column and characterized as a protein related to cathepsin D. An additional metallo‐protease inhibited by EDTA was identified with an optimum activity at neutral pH. This study is an example of how quality and stability of therapeutic recombinant molecules are strongly influenced by cell culture parameters. Biotechnol. Bioeng. 2009; 104: 1132–1141. © 2009 Wiley Periodicals, Inc.
Prolong Egg Storage Affects Broiler Breeder Embryonic Metabolism and Chick Quality

The research investigates the effects of prolonged storage of hatching eggs on eggshell conductance (G) and embryonic metabolism of Ross 308 broiler breeder eggs. Hatching eggs were collected, weighed and stored for 10 days. After 10 days, a second group of eggs was collected as in the first, weighed and stored for additional 4 days to set up two pre-incubation storage treatments (4 days and 14 days). A sample of eggs (n=30) were placed in desiccator to determine the G value. Additional eggs (n=24) were incubated in metabolic chambers to monitor daily embryonic O2 consumption and CO2 production for the calculation of embryonic heat production (EHP), a parameter used to indicator embryonic metabolism. All data were analyzed using SAS Proc Mixed procedure at P ≤ 0.05. Egg storage had no effect on initial egg weight before and after egg storage and G. The O2 consumption, CO2 production and EHP were significant particularly during the mid and late periods of incubation in 4 days compared to 14 days storage. Reduction in embryonic metabolism of 14 days stored eggs during late incubation period in can negatively affect embryonic growth, hatching process and chick quality.
Milk quality, manufacturing properties and blood biochemical profile from dairy cows fed peas ( Pisum sativum L.) as dietary protein supplement

Pea (Pisum sativum L.), a protein-rich legume seed well adapted to many climatic areas and widely used for feed and food, was fed to Italian Friesian breed cows for 16 weeks to assess its effects on milk yield and production, renneting properties and metabolic responses. Cows within each group were assigned to two isonitrogenous and isoenergetic concentrates based on corn plus soybean meal or peas. Individual milk samples were collected from two consecutive milkings, composited, and then analysed for fat, protein, casein and lactose contents and somatic cells count as well as blood and milk urea and milk technological characteristics. Cow blood samples were taken and plasma were analysed for metabolites, biological enzymes, β-hydroxybutyrate (BHBA) and non-esterified fatty acids (NEFA). Peas supplementation had no effects on metabolic blood profile as well as on milk composition traits and clotting aptitude. Milk and blood from cows fed peas indicated a reduction (P<0.05) of their urea concentrations compared to those fed soybean meal. Our findings indicate that peas can replace soybean meal as protein source in diet of dairy cows without unfavourable effects on milk quality and cheesemaking properties.
ISOLATION OF THE PERIAXONAL SPACE OF THE CENTRAL MYELINATED NERVE FIBER WITH REGARD TO THE DIFFUSION OF PEROXIDASE

Horseradish peroxidase was implanted into rat forebrains and the distribution with respect to the periaxonal space was examined. The peroxidase filled the extracellular spaces. Usually, however, the flow stopped at the junction of the outer loop and the outermost lamella of the myelin sheath and at the outermost lateral loop at the node of Ranvier. Therefore, in most cases, the periaxonal space was devoid of peroxidase. Occasionally, however, peroxidase in small amounts evidently penetrated the junctions and could sometimes be clearly demonstrated within the periaxonal space.