Miracle-dz/UniFAR-FTUs huggingface dataset:
From Risk Matrices to Risk Networks in Construction Projects

Risk management is considered as a vital process contributing to the successful outcome of a complex construction project in terms of achieving the associated project objectives. The widely used industrial practice in managing construction project risks is to assign probability and impact values to each risk and to map risks on a risk matrix. The main criticism of this practice relates to ignoring complex interdependencies between risks and using point estimates for probability and impact values. Furthermore, risks mapped on a matrix are deemed to influence a specific objective and there is a challenge involved in aggregating the impact of risks across multiple (conflicting) project objectives. Utilizing a data-driven Bayesian Belief Network methodology, in this paper we introduce a new process where the risks mapped on a risk matrix corresponding to each project objective are aggregated and modeled as a risk network, and a holistic impact of each risk is captured across the network by means of new risk metrics. The proposed methodology is demonstrated through a real application. The results specific to the two ranking schemes (assuming independence/interdependence of risks) are found to be negatively correlated, which substantiates the importance of utilizing an interdependency-based risk management process.
Prep1, a novel functional partner of Pbx proteins

The human transcription factor, UEF3, is important in regulating the activity of the urokinase plasminogen activator (uPA) gene enhancer. The UEF3 DNA target site is a regulatory element in the promoters of several growth factor and protease genes. We reported previously that purified UEF3 is a complex of several subunits. In this paper we report the cloning of the cDNA of one of the subunits which encodes for a novel human homeodomain protein, which we have termed Prep1. The Prep1 homeodomain belongs to the TALE class of homeodomains, is most closely related to those of the TGIF and Meis1 proteins, and like these, recognizes a TGACAG motif. We further identify the other UEF3 subunit as a member of the Pbx protein family. Unlike other proteins known to interact with Pbx, Prep1 forms a stable complex with Pbx independent of DNA binding. Heterodimerization of Prep1 and Pbx results in a strong DNA binding affinity towards the TGACAG target site of the uPA promoter. Overall, these data indicate that Prep1 is a stable intracellular partner of Pbx in vivo.
Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition

Regulated conformational changes of proteins are critical for cellular signal transduction. The spindle checkpoint protein Mad2 is an unusual protein with two native folds: the latent open conformer (O-Mad2) and the activated closed conformer (C-Mad2). During mitosis, cytosolic O-Mad2 binds to the Mad1–Mad2 core complex at unattached kinetochores and undergoes conformational activation to become C-Mad2. C-Mad2 binds to and inhibits Cdc20, an activator of APC/C, to prevent precocious anaphase onset. Here, we show that the conformational transition of Mad2 is regulated by phosphorylation of S195 in its C-terminal region. The phospho-mimicking Mad2S195D mutant and the phospho-S195 Mad2 protein obtained using intein-mediated semisynthesis do not form C-Mad2 on their own. Mad2S195D fails to bind to Cdc20, a low-affinity ligand, but still binds to high-affinity ligands, such as Mad1 and MBP1, forming ligand-bound C-Mad2. Overexpression of Mad2S195D in human cells causes checkpoint defects. Our results indicate that Mad2 phosphorylation inhibits its function through differentially regulating its binding to Mad1 and Cdc20 and establish that the conformational change of Mad2 is regulated by posttranslational mechanisms.
Systemic treatment of anti-CD4CD25 T cell monoclonal antibody exacerbates sialoadenitis in submandibular glands during the early life in lupus-prone female NZB x NZWF mice.

BACKGROUND The maintenance mechanisms of peripheral tolerance by CD4(+)CD25(+) T cells before the development of sialoadenitis in secondary Sjögren's syndrome (sSS) are not well understood. The aim of the present study is to examine the effect of reduction of CD4(+)CD25(+) T cells on the development of sialoadenitis during the early life in female NZB x NZWF(1) (B/WF(1)) mice, a model for human sSS. METHODS Female B/WF(1) mice at 3 days after birth were treated with either anti-mouse CD4(+)CD25(+) T cells rat IgG(1) monoclonal antibody (mAb) or Rat IgG(1)(control). At 25 weeks of age, autoantibodies against nucleus and cytoplasm of ductal epithelial and myoepithelial cells, and histpathology of submandibular glands were examined in the mAb-treated and control groups. Also the development of anti-Ro/SS-A antibodies was examined until 25 weeks of age in both groups. RESULTS The mAb-treated group showed severe lesions with the development of autoantibodies compared to the control group. CONCLUSIONS The present results suggest that peripheral CD4(+)CD25(+) T cells may, at least in part, contribute to down-regulate the development of sialoadenitis in submandibular glands of lupus-prone female B/WF(1) mice during their early life.
Reporting recommendations for tumor marker prognostic studies.

Lisa M. McShane, Biometric Research Branch, National Cancer Institute, Bethesda, MD Douglas G. Altman, Medical Statistics Group, Cancer Research UK, Centre for Statistics in Medicine, Wolfson College, Oxford, UK Willi Sauerbrei, Institut fuer Medizinische Biometrie und Medizinische Informatik, Universitaetsklinikum Freiburg, Freiburg, Germany Sheila E. Taube, Cancer Diagonisis Program, National Cancer Institute, Bethesda, MD Massimo Gion, Centro Regionale Indicatori Biochimici di Tumore, Ospedale Civile, Venezia, Italy Gary M. Clark, OSI Pharmaceuticals Inc, Boulder, CO For the Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Stability and Stabilization of Continuous-Time Switched Linear Systems

This paper addresses two strategies for the stabilization of continuous-time, switched linear systems. The first one is of open loop nature (trajectory independent) and is based on the determination of a minimum dwell time by means of a family of quadratic Lyapunov functions. The relevant point on dwell time calculation is that the proposed stability condition does not require the Lyapunov function to be uniformly decreasing at every switching time. The second one is of closed loop nature (trajectory dependent) and is designed from the solution of what we call Lyapunov-Metzler inequalities from which the stability condition (including chattering) is expressed. Being nonconvex, a more conservative but simpler-to-solve version of the Lyapunov-Metzler inequalities is provided. The theoretical results are illustrated by means of examples.
A universal and multi-dimensional model for analytical data on geological samples

Abstract. To promote the sharing and reutilization of geoanalytical data, various geoanalytical databases have been established over the last 30 years. Data models, which form the core of a database, are themselves the subjects of intensive studies. Data models determine the contents stored in the databases and applications of the databases. However, most geoanalytical data models have been designed for specific geological applications, which has led to strong heterogeneity between databases. It is therefore difficult for researchers to communicate and integrate geoanalytical data between databases. In particular, every time a new database is constructed, the time-consuming process of redesigning a data model significantly increases the development cycle. This study introduces a new data model that is universally applicable and highly efficient. The data model is applied to various geoanalytical methods and corresponding applications, and comprehensive analytical data contents together with associated background metadata are summarized and catalogued. Universal data attributes are then designed based on these metadata, which means that the model can be used for any geoanalytical database. Additionally, a multi-dimensional data mode is adopted, providing geological researchers with the ability to analyze geoanalytical data from six or more dimensions with high efficiency. Part of the model is implemented with the typical database system (MySQL) and comprehensive comparison experiments with existing geoanalytical data model are presented. The result unambiguously proves that the data model developed in this paper exceeds existing models in efficiency.
Zymographic Analysis and Characterization of MMP-2 and -9 Forms in Human Sound Dentin

The role and function of dentin matrix metalloproteinases (MMPs) are not well-understood, but they may play a key role in dentinal caries and the degradation of resin-bonded dentin matrices. To test the null hypothesis that MMP-9 is not found in dentin matrix, we used gelatin zymography to extract and isolate all molecular forms of gelatinolytic MMPs in demineralized mature sound dentin powder obtained from extracted human molars, characterizing and identifying the enzymes by Western blotting. Gelatinolytic MMPs were detected in extracts of demineralized dentin matrix and identified as MMP-2 and MMP-9. Acidic extracts (pH 2.3) yielded 3–8 times more MMP activity than did EDTA (pH 7.4). Their activation may contribute to dentin matrix degradation, which occurs during caries progression and following resin bonding. Inhibition of MMP-2 and -9 proteolytic activity may slow caries progression and increase the durability of resin-dentin bonds.
Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds

The design of proteolysis-targeting chimeras (PROTACs) is a powerful small-molecule approach for inducing protein degradation. PROTACs conjugate a target warhead to an E3 ubiquitin ligase ligand via a linker. Here we examined the impact of derivatizing two different BET bromodomain inhibitors, triazolodiazepine JQ1 and the more potent tetrahydroquinoline I-BET726, via distinct exit vectors, using different polyethylene glycol linkers to VHL ligand VH032. Triazolodiazepine PROTACs exhibited positive cooperativities of ternary complex formation and were more potent degraders than tetrahydroquinoline compounds, which showed negative cooperativities instead. Marked dependency on linker length was observed for BET-degrading and cMyc-driven antiproliferative activities in acute myeloid leukemia cell lines. This work exemplifies as a cautionary tale how a more potent inhibitor does not necessarily generate more potent PROTACs and underscores the key roles played by the conjugation. The provided insights and framework for structure–activity relationships of bivalent degraders are anticipated to have wide future applicability.
PREVALÊNCIA DA INFECÇÃO PELO VÍRUS DA HEPATITE B EM USUÁRIOS DE CRACK NO PIAUÍ

Orientadora: Profa. Dra. Telma Maria Evangelista de Araujo. 1a Membro Externo: Profa. Dra. Elba Gomide Mochel (UFMA). Membro Interno: Profa. Dra. Claudete Ferreira de Souza Monteiro.
Level of response to alcohol as a factor for targeted prevention in college students.

BACKGROUND Heavy alcohol consumption and alcohol problems among college students are widespread and associated with negative outcomes for individuals and communities. Although current methods for prevention and intervention programming have some demonstrated efficacy, heavy drinking remains a problem. A previous pilot study and a recent large-scale evaluation (Schuckit et al., , ) found that a tailored prevention program based on a risk factor for heavy drinking, low level of response (low LR) to alcohol, was more effective at reducing heavy drinking than a state-of-the-art (SOTA) standard prevention program for individuals with the low LR risk factor. METHODS This study enrolled 231 first-semester college freshmen with either high or low LR into the same level of response-based (LRB) or SOTA online prevention programs as in the previous reports (consisting of 4 weeks of video modules), as well as a group of matched controls not receiving alcohol prevention, and compared changes in alcohol use between these groups across a 6-month period. RESULTS Individuals in alcohol prevention programs had a greater reduction in maximum drinks per occasion and alcohol use disorder symptoms than controls. There was limited evidence for interactions between LR and prevention group in predicting change in alcohol use behaviors; only among participants with strict adherence to the program was there an interaction between LR and program in predicting maximum drinks per occasion. However, overall, low LR individuals showed greater decreases in drinking behaviors, especially risky behaviors (e.g., maximum drinks, frequency of heavy drinking) than high LR individuals. CONCLUSIONS These results indicate that prevention programs, including brief and relatively inexpensive web-based programs, may be effective for persons at highest risk for heavier drinking, such as those with a low LR. Tailored programs may provide incremental benefits under some conditions. Long-term follow-ups and further investigations of tailored prevention programs based on other risk factors are needed.
Henry Fowler and his eighteenth-century predecessors

AbstractFowler's Modern English Usage (1926) is a typical product of the prescription age, the final stage in the standardisation process of the English language. With two further editions, one by Gowers (1965) and the other by Burchfield (1996) and a reprint planned by OUP for their World's Classics Series in 2009 with an introduction by David Crystal, the book attracts considerable interest, both for the purpose for which it was originally written, i.e. as a usage guide, and as a phenomenon in its own right. Burchfield, in his introduction, stresses “the isolation of Fowler from the mainstream of the linguistic scholarship of his day” (1996:vii), but if we look at the man and his work in the context of prescriptivism, we will be able to see that MEU fits into the tradition of the usage guide such as it originated in the latter half of the eighteenth century. Many of the linguistic strictures discussed by Fowler are part of a prescriptive canon that is some 250 years old, and for the origin of which the .
Statistik teori dan aplikasi (Edisi ke-7 - Jilid 1) / J. Supranto

Buku karangan ahli statistika Indonesia terkemuka J. Supranto ini sudah sangat dikenal di kalangan akademis. Bagi para mahasiswa yang baru mempelajari Statistika, buku edisi ketujuh ini memberikan pemahaman yang komprehensif namun ringkas karena dilengkapi dengan istilah penting, ringkasan rumus, dan aplikasi komputer dalam tiap bab. Edisi terbaru ini juga dilengkapi dengan data mutakhir, penjelasan tentang empat skala utama (nominal, ordinal, interval, dan rasio), dan penjelasan singkat beserta contoh tentang sampling acak.
Fast relief: buying time with medications.

The experience of time famine in contemporary U.S. culture affects household decisions about self-care and the use of pharmaceuticals for self-medication. This article examines the manner in which time demands shape lay interpretations of medicine efficacy and drive increases in medication use for adults as well as children. Medicines, like other time-saving commodities, appear to shift the time-power differential in favor of individuals, placing them in control of how time is spent. When there is "no time to be sick," allopathic medicines become time-saving devices that enable women to fulfill responsibilities at work or home while they attend to sick children or to being ill themselves. Medicines are used to beat the clock by increasing one's own capacity to be productive.
Voltage-MPPT Controller Design of Photovolatic Array System Using Fuzzy Logic Controller

In this article a fuzzy logic controller is proposed to control the output voltage of a photovoltaic (PV) system while tracking the maximum power point (MPP) of the system. The PV system usually consists of: a PV array that converts solar energy to electrical energy, a DC/DC converter that converters low dc voltages produced by the PV array to a high dc voltage. General design of the buck-boost converter-load system is presented with Matlab/Simulink. In the FLC, different fuzzy membership functions are used and the results are compared with each other. The effects of the different fuzzy membership functions and the PV module parameters on the controller are also compared. Results are compared with typical hill-climbing methods.
CSI in the Web 2.0 Age: Data Collection, Selection, and Investigation for Knowledge Discovery

The growing popularity of various Web 2.0 media has created massive amounts of user-generated content such as online reviews, blog articles, shared videos, forums threads, and wiki pages. Such content provides insights into web users’ preferences and opinions, online communities, knowledge generation, etc., and presents opportunities for many knowledge discovery problems. However, several challenges need to be addressed: data collection procedure has to deal with unique characteristics and structures of various Web 2.0 media; advanced data selection methods are required to identify data relevant to specific knowledge discovery problems; interactions between Web 2.0 users which are often embedded in user-generated content also need effective methods to identify, model, and analyze. In this dissertation, I intend to address the above challenges and aim at three types of knowledge discovery tasks: (data) collection, selection, and investigation. Organized in this “CSI” framework, five studies which explore and propose solutions to these tasks for particular Web 2.0 media are presented. In Chapter 2, I study focused and hidden Web crawlers and propose a novel crawling system for Dark Web forums by addressing several unique issues to hidden web data collection. In Chapter 3 I explore the usage of both topical and sentiment information in web crawling. This information is also used to label nodes in web graphs that are employed by a graph-based tunneling mechanism to improve collection recall. Chapter 4 further extends the work in Chapter 3 by exploring the possibilities for other graph comparison techniques to be used in tunneling for focused crawlers. A subtree-based tunneling method which can scale up to large graphs is
LC3/GABARAP family proteins: autophagy‐(un)related functions

From yeast to mammals, autophagy is an important mechanism for sustaining cellular homeostasis through facilitating the degradation and recycling of aged and cytotoxic components. During autophagy, cargo is captured in double‐membraned vesicles, the autophagosomes, and degraded through lysosomal fusion. In yeast, autophagy initiation, cargo recognition, cargo engulfment, and vesicle closure is Atg8 dependent. In higher eukaryotes, Atg8 has evolved into the LC3/GABARAP protein family, consisting of 7 family proteins [LC3A(2 splice variants), LC3B, LC3C, GABARAP, GABARAPL1, and GABARAPL2]. LC3B, the most studied family protein, is associatedwith autophagosome development and maturation and is used tomonitor autophagic activity. Giventhe high homology, the other LC3/GABARAP family proteins are often presumed to fulfill similar functions. Nevertheless, substantial evidence shows that the LC3/GABARAP family proteins are unique in function and important in autophagy‐independent mechanisms. In this review, we discuss the current knowledge and functions of the LC3/GABARAP family proteins. We focus on processing of the individual family proteins and their role in autophagy initiation, cargo recognition, vesicle closure, and trafficking, a complex and tightly regulated process that requires selective presentation and recruitment of these family proteins. In addition, functions unrelated to autophagy of the LC3/GABARAP protein family members are discussed. —Schaaf, M. B. E. , Keulers, T. G, Vooijs, M. A. , Rouschop, K. M. A. LC3/GABARAP family proteins: autophagy‐(un)related functions. FASEB J. 30, 3961–3978 (2016). www.fasebj. org
Cortisol Circadian Rhythm and 24-Hour Holter Arterial Pressure in OSAS Patients

Obstructive sleep apnea syndrome (OSAS) is a syndrome in which the principal symptom is apnea during sleep. Hypoxia in OSAS is a stress condition, which when prolonged in time, could alter hypothalamo-hypophysial-suprarenal control and the cortisol cicadian rhythm. We studied 28 patients with OSAS (30–60 years old), 20 female and 8 male. We calculated the OSAS class according to the Simmons classification. Twenty of the 28 patients maintained unmodified cortisol circadian rhythms, while 8 had cortisol levels more elevated in late and nocturnal hours. Holter monitoring showed arterial hypertension in 8 of the 28 patients (the same patients with cortisol circadian rhythm alteration). Our data seem to indicate that when the OSAS patients lack cortisol circadian rhythm they are having arterial hypertension.
Phantom studies investigating extravascular density imaging for partial volume correction of 3-D PET /sup 18/FDG studies

Limited scanner resolution and cardiac motion contribute to partial volume (PV) averaging of cardiac PET images. An extravascular (EV) density image, created from the subtraction of a blood pool scan from a transmission image, has been used to correct for PV averaging in H/sub 2//sup 15/O studies using 2-D imaging but not with 3-D imaging of other tracers such as /sup 18/FDG. A cardiac phantom emulating the left ventricle was used to characterize the method for use in 3-D PET studies. Measurement of the average myocardial activity showed PV losses of 32% below the true activity (p<0.001). Initial application of the EV density correction still yielded a myocardial activity 13% below the true value (p<0.001). This failure of the EV density image was due to the 1.66 mm thick plastic barrier separating the myocardial and ventricular chambers within the phantom. Upon removal of this artifact by morphological dilation of the blood pool, the corrected myocardial value was within 2% of the true value (p=ns). Spherical ROIs (diameter of 2 to 10 mm), evenly distributed about the myocardium, were also used to calculate the average activity. The EV density image was able to account for PV averaging throughout the range of diameters to within a 5% accuracy, however, a small bias was seen as the size of the ROIs increased. This indicated a slight mismatch between the emission and transmission image resolutions, a result of the difference in data acquisitions (i.e., span and ring difference) and default smoothing. These results show that the use of EV density image to correct for PV averaging is possible with 3-D PET. A method of correcting barrier effects in phantoms has been presented, as well as a process for evaluating resolution mismatch.
Noise Reduction Method for Image Signal Processor Based on Unified Image Sensor Noise Model

SUMMARY The noise in digital images acquired by image sensors has complex characteristics due to the variety of noise sources. However, most noise reduction methods assume that an image has additive white Gaussian noise (AWGN) with a constant standard deviation, and thus such methods are not e ﬀ ective for use with image signal processors (ISPs). To e ﬃ ciently reduce the noise in an ISP, we estimate a uniﬁed noise model for an image sensor that can handle shot noise, dark-current noise, and ﬁxed-pattern noise (FPN) together, and then we adaptively reduce the image noise using an adaptive Smallest Univalue Segment Assimilating Nucleus (SUSAN) ﬁlter based on the uniﬁed noise model. Since our noise model is a ﬀ ected only by image sensor gain, the parameters for our noise model do not need to be re-conﬁgured depending on the contents of image. Therefore, the proposed noise model is suitable for use in an ISP. Our experimental results indicate that the proposed method reduces image sensor noise e ﬃ ciently.