Miracle-dz/UniFAR-FTUs huggingface dataset:
Measurement of Shear Wave Velocity Using Acoustic Radiation Force Impulse Imaging is not Hampered by Previous Use of Ultrasound Contrast Agents

Abstract Purpose: To assess the inter-observer reproducibility of acoustic radiation force impulse imaging (ARFI) between 2 skilled physicians and to evaluate if ultrasound contrast agents (UCA) affect the measurement of shear wave velocity (SWV) using ARFI. Patients and Methods: 53 patients (29 males, 24 females, 59 ± 15 [22 – 84] years) who underwent contrast enhanced ultrasound (CEUS) examination were included. ARFI was performed on liver segment V by physicians A and B before CEUS, and by physician A within 4 – 6 minutes and 7 – 10 minutes after contrast injection. In a subgroup of 31 patients (15 males, 16 females, 57 ± 18 [22 – 84] years), ARFI was also performed on focal liver lesions (FLL) by physician A before CEUS, and within 4 – 6 minutes and 7 – 10 minutes after contrast injection. Results: The SWV values obtained by physician A and B before CEUS yielded an intra-class correlation coefficient value of 0.913 (95 % CI, 0.849 – 0.950). No significant differences were shown between the SWV values of liver segment V in all 53 patients and of FLL in the subgroup of 31 patients obtained before CEUS and that of within 4 – 6 minutes and 7 – 10 minutes after contrast injection (all P> 0.05). Conclusion: ARFI showed excellent inter-observer reproducibility between 2 skilled physicians. UCA did not affect the measurement of SWV in both liver parenchyma and FLL, at least when performed 4 minutes after the contrast injection. ARFI may become an additional tool in the differential diagnosis of FLL.
Strain decoupling reveals variable seismogenic risk in SE Japan (Nankai Trough)

The determination of in situ stress states is vital in understanding the behavior of faults and subsequent seismogenesis of accretionary prisms. In this paper, a high‐quality 3‐D seismic volume is used to map the depth of the extensional‐compressional decoupling (ECD) boundary in the accretionary prism of Nankai, with the prior knowledge that strike‐slip and compressional stresses occur deeper than 1250 m below seafloor (mbsf) in the Kumano Basin, changing to extension toward the seafloor. A total of 1108 faults from the accretionary prism are analyzed to estimate paleostresses via fault inversion and slip tendency techniques. A key result in this paper is that the ECD boundary can be used as a proxy to identify active structures on accretionary prisms as its depth depends on (a) local tectonic uplift in areas adjacent to active faults and (b) the thickness of sediment accumulated above active thrust anticlines. The depth of the ECD boundary ranges from 0 to ∼650 mbsf, being notably shallower than in the Kumano Basin. In Nankai, frontal regions of the imbricate‐thrust zone, and the megasplay fault zone, reveal the shallower ECD depths and correlate with the regions where faulting is most active. As a corollary, this work confirms that estimates of stress state variability based on the analysis of 3‐D seismic data are vital to understand the behavior of faults and potential seismogenic regions on convergent margins.
A combined transmitting coil design for high efficiency WPT of endoscopic capsule

This paper presents a combined wireless power transmitting coil designed for endoscopic capsule. In the design, a group of vertically segmented transmitting coils are combined to work. According to the position of the capsule, one, two or three segmented transmitting coils will be selected to work, which makes the capsule closer to the center of the combined transmitting coils. The mechanism ensures high power transfer efficiency and good homogeneity of the energy distribution. This paper also gives the theoretical expression about how to combine the segmented transmitting coils to work together with the highest performances. The experiments show that the minimum and average AC-AC transfer efficiency are 7.53% and 12.7% respectively.
Asthma nurse practice improves outcomes and reduces costs in primary health care.

OBJECTIVE The aim of this study was to elucidate the care of patients with asthma in primary health care from medical, patient self-management, health, quality of life, and health economic perspectives. METHODS Asthma nurse practice (ANP), an alternative asthma self-management strategy, was compared with traditional asthma care in primary health care in southern Sweden regarding medical history, lifestyle, self-management, symptoms caused by asthma, effects on sick leave, state of health, quality of life and health care costs. The first part of the investigation comprised a retrospective study of a randomly selected sample of patient records of asthmatics (n=152). The second part, lasting 3 months, was prospective and included consecutive patients visits (n=347). RESULTS The ANP approach showed better results in most of the evaluated outcomes such as asthma quality documentation and self-management and the number of asthma symptoms was significantly lower. From a health economic perspective the results were encouraging with respect to ANP. CONCLUSION This alternative asthma strategy, ANP, improved asthma care in primary health care and resulted in economic advantages in the health care sector. However the result may only be generalized to other practices working with asthma nurses in the same way.
Ontologies étendues pour l'annotation sémantique

This article tries to formalize the process of semantically annotating a text with respect to an ontology. The semantic annotation puts fragments of a text in correspondence with the elements of an ontology, but all the difficulties consist in identifying fragments to be annotated and labels to be associated with them. We propose in this paper to extend ontologies by semantic annotation rules instead of by additional meta-lexical properties. This solution allows reusing best NLP tools which produce linguistic annotations at each of their levels. It also has the merit to distinguish clearly the process of linguistic analysis and the ontological interpretation.
Factorial validity of the Problematic Facebook Use Scale for adolescents and young adults

Background and aims Recent research on problematic Facebook use has highlighted the need to develop a specific theory-driven measure to assess this potential behavioral addiction. The aim of the present study was to examine the factorial validity of the Problematic Facebook Use Scale (PFUS) adapted from Caplan’s Generalized Problematic Internet Scale model. Methods A total of 1,460 Italian adolescents and young adults (aged 14–29 years) participated in the study. Confirmatory factor analyses were performed in order to assess the factorial validity of the scale. Results Results revealed that the factor structure of the PFUS provided a good fit to the data. Furthermore, results of the multiple group analyses supported the invariance of the model across age and gender groups. Discussion and conclusions This study provides evidence supporting the factorial validity of the PFUS. This new scale provides a theory-driven tool to assess problematic use of Facebook among male and female adolescents and young adults.
Integrating Vision Modules: Stereo, Shading, Grouping, and Line Labeling

It is generally agreed that individual visual cues are fallible and often ambiguous. This has generated a lot of interest in design of integrated vision systems which are expected to give a reliable performance in practical situations. The design of such systems is challenging since each vision module works under a different and possibly conflicting set of assumptions. We have proposed and implemented a multiresolution system which integrates perceptual organization (grouping), segmentation, stereo, shape from shading, and line labeling modules. We demonstrate the efficacy of our approach using images of several different realistic scenes. The output of the integrated system is shown to be insensitive to the constraints imposed by the individual modules. The numerical accuracy of the recovered depth is assessed in case of synthetically generated data. Finally, we have qualitatively evaluated our approach by reconstructing geons from the depth data obtained from the integrated system. These results indicate that integrated vision systems are likely to produce better reconstruction of the input scene than the individual modules. >
Aerodynamic Model Analysis and Flight Simulation Research of UAV Based on Simulink

Mathematical simulation method can be adopted to check flight characteristic of UAV, also can be adopted to simulate hardware experiments of unmanned aerial vehicle (UAV), then related flight experiments can be performed. The simulation method can reduce the flight periods, cost and risk. UAV flight model research play an important role in simulation and modeling in initialize periods of the UAV producing. The study of the paper focuses on the aerodynamic force modeling work of UAV based on Simulink. The designed model not only can afford mathematics simulation experiment but also will do benefits to the research of flight control, navigation guidance of UAV.
Mammalian nuclear transfer

During development, the genetic content of each cell remains, with a few exceptions, identical to that of the zygote. Differentiated cells, therefore, retain all the genetic information necessary to generate an entire organism (nuclear totipotency). Nuclear transfer (NT) was initially developed to test experimentally this concept by cloning animals from differentiated cells. It has, since then, been used to study the role of genetic and epigenetic alterations during development and disease. In this review, we highlight some of the milestones in mammalian NT reached in the 50 years after the first nuclear transplantations in frogs. We also address problems associated with mammalian nuclear transfer and provide a survey on current NT and stem cell technology. In the long term, nuclear transfer or alternative strategies aim to generate customized pluripotent cells, which would be invaluable to medical research and therapy. Developmental Dynamics 235:2460–2469, 2006. © 2006 Wiley‐Liss, Inc.
Endonasal Laser Surgery With a New Laser Fiber Guidance Instrument

INTRODUCTION Las r proc dures a re common in surgery of the head and n ck nd in various oth r m dical fi elds. Th laser is us d s an djunct or substitute for conv ntional surgical tr atm nt. In th manag m nt of chronic turbinate hypertrophy, 1 ser surg ry is a promising procedure, 110 but it is awkward to manipulate th laser fiber in combination with rhinoscopic quipment and suction d vices. In light of the smok and toxic pyrolysis ag nts g nerat d by th las r,u the disadvantage of inaccurate positioning, and the n ed for a control I d ov rvi w of the trea tm nt area, we hav dev lop d a new d vice and tre tment technique for tissue r mov 1 in nasal turbinate surgery.
Membrane Topology of NHE3

Experimental data indicate that the relatively hydrophilic carboxyl-terminal domains of Na+-H+ exchangers mediate the regulation of transporter activity through interactions with cytoskeletal effectors. It has therefore been assumed that this entire domain lies on the cytoplasmic surface of the plasma membrane. The purpose of the present study was to determine the membrane orientation of the COOH-terminal 131 amino acids of Na+-H+exchanger isoform NHE3 by use of three monoclonal antibodies that recognize at least two distinct epitopes within this region. Enzyme-linked immunosorbent assay studies demonstrated binding of these monoclonal antibodies (mAbs) to intact right-side-out renal brush border membrane vesicles in the absence of detergent. Moreover, when coupled to an affinity matrix to isolate membrane vesicles, the anti-NHE3 mAbs bound structures that were morphologically identical to intact microvilli. To confirm the identity of the exoplasmic antigen bound by the antibodies, immunoprecipitation studies were performed. Intact right-side-out brush border membrane vesicles were incubated with the mAbs in the absence of detergent. The membranes were pelleted, supernatant with unbound antibody was removed, the pellet was solubilized, and then immunoprecipitation with secondary antibody was performed. Immunoblot analysis indicated that NHE3 was precipitated after binding of the mAbs to intact membranes. Finally, the localization of the mAb epitopes was determined using high resolution immunocytochemistry. Ultrathin cryosections of rat kidney were labeled with the mAbs and bound antibody detected with the colloidal gold technique. Labeling was restricted to the exoplasmic surface of microvilli of the proximal tubule. Taken together, these findings indicate that epitopes within the carboxyl terminus of the Na+-H+ exchanger isoform NHE3 are exposed to the outside of the plasma membrane.
A STUDY OF DÖDERLEIN'S VAGINAL BACILLUS *

Since the observations and findings of numerous workers tend to indicate that the Doderlein bacillus is a constant and, in some instances, the only inhabitant of the normal vagina, it becomes of interest to gain insight concerning the characterization of this organism. There have been a number of efforts by many to classify this organism, but workers in this field have encountered difficulty in isolating these bacteria from mixed cultures and in maintaining them. Lash and Kaplan' have described the morphology and some cultural reaction of strains of Doderlein's bacillus. These results indicate that this is not one species of bacteria. Thomas2 compared several strains of Doderlein bacilli on a morphologic and cultural basis, and showed that they are closely related to Lactobacillus acidophilus. Studies by Cruickshank and Sharman3 and by Cruickshank4 have emphasized the importance of knowing something concerning the classification of these organisms.
The MAgNet: Agent-based middleware enabling social networking for mobile users

Nowadays social network services play an important role in users' everyday lives. This is especially emphasized in lives of users that belong to Generation Y. Young people often communicate and share various personal information with their family, friends or colleagues through virtual communities that are based on social relations. By introducing social networking concept into the mobile network domain, proliferation and availability of social networking services could be notably expanded. This paper presents the MAgNet, a middleware based on software agent technology that enables social networking services for users in the mobile network domain. The MAgNet enables mobile users to define and customize their social relationships with other users, as well as it uses created relationships to plan and manage group events.
Quality by design: optimization of a freeze-drying cycle via design space in case of heterogeneous drying behavior and influence of the freezing protocol

Purpose: This paper shows how to optimize the primary drying phase, for both product quality and drying time, of a parenteral formulation via design space. Methods: A non-steady state model, parameterized with experimentally determined heat and mass transfer coefficients, is used to define the design space when the heat transfer coefficient varies with the position of the vial in the array. The calculations recognize both equipment and product constraints, and also take into account model parameter uncertainty. Results: Examples are given of cycles designed for the same formulation, but varying the freezing conditions and the freeze-dryer scale. These are then compared in terms of drying time. Furthermore, the impact of inter-vial variability on design space, and therefore on the optimized cycle, is addressed. With this regard, a simplified method is presented for the cycle design, which reduces the experimental effort required for the system qualification. Conclusions: The use of mathematical modeling is demonstrated to be very effective not only for cycle development, but also for solving problem of process transfer. This study showed that inter-vial variability remains significant when vials are loaded on plastic trays, and how inter-vial variability can be taken into account during process design.
A Staggered Discontinuous Galerkin Method with Local TV Regularization for the Burgers Equation

The staggered discontinuous Galerkin (SDG) method has been recently developed for the numerical approximation of partial differential equations. An important advantage of such methodology is that the numerical solution automatically satisfies some conservation properties which are also satisfied by the exact solution. In this paper, we will consider the numerical approximation of the inviscid Burgers equation by the SDG method. For smooth solutions, we prove that our SDG method has the properties of mass and energy conservation. It is well-known that extra care has to be taken at locations of shocks and discontinuities. In this respect, we propose a local total variation (TV) regularization technique to suppress the oscillations in the numerical solution. This TV regularization is only performed locally where oscillation is detected, and is thus very efficient. Therefore, the resulting scheme will preserve the mass and energy away from the shocks and the numerical solution is regularized locally near shocks. Detailed description of the method and numerical results are presented.
Long-Term Safety and Efficacy of Programmable Implantable Insulin Delivery Systems

Objectives Since only short-term studies of continuous intraperitoneal insulin infusion (CIPII) therapy using implantable programmable insulin delivery systems have been performed to show this method of diabetes therapy to be safe and efficacious, we have performed long-term studies to assess its safety and efficacy. Research design and methods For 78 patient-years of follow-up, we have longitudinally studied the incidence of diabetic ketoacidosis and severe hypoglycemia in 25 type 1 diabetic patients treated with CIPII. We also compared, cross-sectionally, the long-term safety and efficacy of CIPII to intensive subcutaneous insulin therapy using intermittent injections or continuous subcutaneous insulin infusion. Finally, we examined the relationship between glycated hemoglobin levels and the standard deviation of daily blood glucose excursion. Results Cross-sectional analysis revealed similar degrees of metabolic control accompanied by significantly decreased rates of both ketoacidosis (0.013 events/patient/year) and severe hypoglycemia (0.05 events/patient/year) during CIPII compared to intermittent injections and continuous subcutaneous insulin infusion therapy. A four-fold decrease in the rate of severe hypoglycemia was observed during longitudinal comparison of pre- and post-implantation complication rates. A relationship was also shown between decreased levels of mean glycated hemoglobin and the standard deviation of blood glucose excursions during CIPII therapy. Conclusions Our data demonstrate that long-term therapy with CIPII is as effective as other methods in achieving near-normal levels of glycated hemoglobin, which in CIPII is associated with a decreased standard deviation of blood glucose excursions. Further, CIPII using implantable programmable insulin delivery systems is the safest method described for intensive insulin therapy in home blood glucose monitoring type 1 diabetic patients.
EH-UNMSM: E-Health Cloud para la mejora de procesos de la clínica universitaria UNMSM mediante una arquitectura de microservices

Propone el desarrollo de un E-Health Cloud describiendo el analisis de procesos, identificacion de requerimientos de software, diseno de wireframes, comunicacion de componentes, infraestructura, estrategia de pruebas y despliegue en la nube. El E-Health Cloud propuesto permite mejorar el proceso de diagnostico, interoperabilidad entre areas medicas y oportunidad de consulta en historias clinicas usando una arquitectura de software basada en microservicios. Para la gestion del presente trabajo se aplica el marco de trabajo Scrum, con el objetivo de construir un software esperado por los usuarios de la clinica.
Genetic control of the cell division cycle in yeast.

Mitotic cell division in eukaryotes is accomplished through a highly reproducible temporal sequence of events that is common to almost all higher organisms. An interval of time, Gl, separates the previous cell division from the initiation of DNA synthesis. Ohromosome replication is acco’mplished during the DNA synthetic period, S, which typically occupies about a third of the cell cycle. Another interval of time, G2, separates the completion of DNA synthesis from prophase, the beginning of mitosis, M. A dramatic sequence of changes in chromosome structure and of chromosome ,movement characterizes the brief mitotic period that results in the precise separation of sister chromatids to daughter nuclei. Mitosis is followed by cytokinesis, the partitioning of the cytoplasm into two daughter cells with separate plasma membranes. In some organisms the cycle is completed by cell wall separation. Each of these events occurs during the cell division cycle of the yeast, Saccharomyces cerevisiae (I) (Fig. 1) . However, two features which distinguish the cell cycle of S. cerevisiae from most other eukaryotes are particularly useful for an analysis of the gene functions that control the cell division cycle. First, the fact that both haploid and diploid cells undergo mitosis permits the isolation of recessive mutations in haploids and their analysis by complementation in diploids. Second, the daughter cell is recognizable at an early stage of the cell cycle as a bud on the surface of the parent cell. Since the ratio of bud size to parent cell size increases progressively during the cycle, this ratio pro-
Single‐walled carbon nanotubes as near‐infrared optical biosensors for life sciences and biomedicine

Single‐walled carbon nanotubes that emit photostable near‐infrared fluorescence have emerged as near‐infrared optical biosensors for life sciences and biomedicine. Since the discovery of their near‐infrared fluorescence, researchers have engineered single‐walled carbon nanotubes to function as an optical biosensor that selectively modulates its fluorescence upon binding of target molecules. Here we review the recent advances in the single‐walled carbon nanotube‐based optical sensing technology for life sciences and biomedicine. We discuss the structure and optical properties of single‐walled carbon nanotubes, the mechanisms for molecular recognition and signal transduction in single‐walled carbon nanotube complexes, and the recent development of various single‐walled carbon nanotube‐based optical biosensors. We also discuss the opportunities and challenges to translate this emerging technology into biomedical research and clinical use, including the biological safety of single‐walled carbon nanotubes. The advances in single‐walled carbon nanotube‐based near‐infrared optical sensing technology open up a new avenue for in vitro and in vivo biosensing with high sensitivity and high spatial resolution, beneficial for many areas of life sciences and biomedicine.