Miracle-dz/UniFAR-FTUs huggingface dataset:
An investigation of the accuracy and reliability of body composition assessed with a handheld electrical impedance myography device

Abstract The purpose of this study was to compare the body fat per cent (BF%) assessed with a unique handheld electrical impedance myography (EIM) device, along with other popular methods, to dual-energy X-ray absorptiometry (DXA). Participants included 33 males (aged 24.3 ± 4.6 years) and 38 females (aged 25.3 ± 8.9 years) who completed 2 visits separated by 24–72 h. The assessments included DXA, bioelectrical impedance analysis (BIA), skinfold measures (SKF), and three separate EIM measurements. No significant differences in BF% (P > 0.05) were found between all EIM assessments when compared against DXA for both males and females for each visit. All methods showed no significant differences in BF% (P > 0.05) between days within themselves. Across both days, the standard error of the estimate (SEE) for the EIM measurements ranged from 2.66% to 3.15%, the SEE for BIA was 2.80 and 2.85, and for SKF was 2.90 and 2.82. The 95% limits of agreement ranged from ±5.34% to ±6.38% for EIM measurements and were highest for SKF (±7.42% and ±7.47%). The total error for both days was largest for SKF (5.20% and 5.35%) and lowest for the EIM measurements (2.48–3.24%). This investigation supports use of a handheld EIM device as an accurate and reliable method of estimating BF% compared to DXA in young, apparently healthy individuals with BF% in the range of 10–22% for males and 20–32% in females and suggests this EIM device be considered a viable alternative to other established field measurements in this population.
Divergence of ectodermal and mesodermal gene regulatory network linkages in early development of sea urchins

Significance Sea urchins (echinoids) consist of two subclasses, cidaroids and euechinoids. Research on gene regulatory networks (GRNs) in the early development of three euechinoids indicates that little appreciable change has occurred to their linkages since they diverged ∼90 million years ago (mya). I asked whether this conservation extends to all echinoids. I systematically analyzed the spatiotemporal expression and function of regulatory genes segregating euechinoid ectoderm and mesoderm in a cidaroid. I report marked divergence of GRN architecture in early embryonic specification of the oral–aboral axis in echinoids. Although I found evidence for diverged regulation of both mesodermal and ectodermal genes, comparative analyses indicated that, since these two clades diverged 268 mya, mesodermal GRNs have undergone significantly more alterations than ectodermal GRNs. Developmental gene regulatory networks (GRNs) are assemblages of gene regulatory interactions that direct ontogeny of animal body plans. Studies of GRNs operating in the early development of euechinoid sea urchins have revealed that little appreciable change has occurred since their divergence ∼90 million years ago (mya). These observations suggest that strong conservation of GRN architecture was maintained in early development of the sea urchin lineage. Testing whether this holds for all sea urchins necessitates comparative analyses of echinoid taxa that diverged deeper in geological time. Recent studies highlighted extensive divergence of skeletogenic mesoderm specification in the sister clade of euechinoids, the cidaroids, suggesting that comparative analyses of cidaroid GRN architecture may confer a greater understanding of the evolutionary dynamics of developmental GRNs. Here I report spatiotemporal patterning of 55 regulatory genes and perturbation analyses of key regulatory genes involved in euechinoid oral–aboral patterning of nonskeletogenic mesodermal and ectodermal domains in early development of the cidaroid Eucidaris tribuloides. These results indicate that developmental GRNs directing mesodermal and ectodermal specification have undergone marked alterations since the divergence of cidaroids and euechinoids. Notably, statistical and clustering analyses of echinoid temporal gene expression datasets indicate that regulation of mesodermal genes has diverged more markedly than regulation of ectodermal genes. Although research on indirect-developing euechinoid sea urchins suggests strong conservation of GRN circuitry during early embryogenesis, this study indicates that since the divergence of cidaroids and euechinoids, developmental GRNs have undergone significant, cell type–biased alterations.
The Negative Feedback-Loop between the Oncomir Mir-24-1 and Menin Modulates the Men1 Tumorigenesis by Mimicking the “Knudson’s Second Hit”

Multiple endocrine neoplasia type 1 (MEN1) syndrome is a rare hereditary cancer disorder characterized by tumors of the parathyroids, of the neuroendocrine cells, of the gastro-entero-pancreatic tract, of the anterior pituitary, and by non-endocrine neoplasms and lesions. MEN1 gene, a tumor suppressor gene, encodes menin protein. Loss of heterozygosity at 11q13 is typical of MEN1 tumors, in agreement with the Knudson’s two-hit hypothesis. In silico analysis with Target Scan, Miranda and Pictar-Vert softwares for the prediction of miRNA targets indicated miR-24-1 as capable to bind to the 3′UTR of MEN1 mRNA. We investigated this possibility by analysis of miR-24-1 expression profiles in parathyroid adenomatous tissues from MEN1 gene mutation carriers, in their sporadic non-MEN1 counterparts, and in normal parathyroid tissue. Interestingly, the MEN1 tumorigenesis seems to be under the control of a “negative feedback loop” between miR-24-1 and menin protein, that mimics the second hit of Knudson’s hypothesis and that could buffer the effect of the stochastic factors that contribute to the onset and progression of this disease. Our data show an alternative way to MEN1 tumorigenesis and, probably, to the “two-hit dogma”. The functional significance of this regulatory mechanism in MEN1 tumorigenesis is also the basis for opening future developments of RNA antagomir(s)-based strategies in the in vivo control of tumorigenesis in MEN1 carriers.
Joint Resource Allocation for Throughput Enhancement in Cognitive Radio Femtocell Networks

In cognitive radio femtocell network (CRFN), secondary users (SUs) cooperatively sense a spectrum band to decide the presence of primary network. However, this sensing overhead generally degrades the throughput performance. The prior work, to resolve this problem, proposed algorithms either to decrease the time spent in sensing or to decrease the number of SUs participating in sensing. In this paper, we propose a joint resource allocation (RA) strategy considering the time and energy consumed for spectrum sensing to maximize the throughput while satisfying the target detection performance in CRFN. Furthermore, to reduce the resources used in spectrum sensing additionally, we also adopt the right censored order statistics based cooperative spectrum sensing scheme, which produces the criterion for deciding the set of reporting SUs. By so jointly designing the time and energy for sensing, the proposed joint RA scheme provides the improvement of spectral efficiency. Through simulation results, it is shown that the proposed joint RA scheme exhibits the enhanced performance over the conventional ones in terms of total throughput of secondary networks.
Double- and Triple-Duty Caregiving Men: An Examination of Subjective Stress and Perceived Schedule Control

Based on the stress process model of family caregiving, this study examined subjective stress appraisals and perceived schedule control among men employed in the long-term care industry (workplace-only caregivers) who concurrently occupied unpaid family caregiving roles for children (double-duty child caregivers), older adults (double-duty elder caregivers), and both children and older adults (triple-duty caregivers). Survey responses from 123 men working in nursing home facilities in the United States were analyzed using multiple linear regression models. Results indicated that workplace-only and double- and triple-duty caregivers’ appraised primary stress similarly. However, several differences emerged with respect to secondary role strains, specifically work–family conflict, emotional exhaustion, and turnover intentions. Schedule control also constituted a stress buffer for double- and triple-duty caregivers, particularly among double-duty elder caregivers. These findings contribute to the scarce literature on double- and triple-duty caregiving men and have practical implications for recruitment and retention strategies in the health care industry.
Vancomycin levels are frequently subtherapeutic in critically ill patients: a prospective observational study

Appropriate utilization of vancomycin is important to attain therapeutic targets while avoiding clinical failure and the development of antimicrobial resistance. Our aim was to observe the use of vancomycin in an intensive care population, with the main focus on achievement of therapeutic serum concentrations (15–20 mg/l) and to evaluate how this was influenced by dose regimens, use of guidelines and therapeutic drug monitoring.
The feasibility of utilizing plasma MiRNA107 and BACE1 messenger RNA gene expression for clinical diagnosis of amnestic mild cognitive impairment.

OBJECTIVE To investigate the relationship between microRNA107 (miRNA107) and BACE1 messenger RNA (mRNA) gene expressions in plasma and their diagnostic capability to distinguish subjects with amnestic mild cognitive impairment from healthy controls. METHOD We recruited 97 patients with Alzheimer's disease according to diagnostic criteria of DSM-IV and National Institute of Neurologic and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association, 116 subjects with amnestic mild cognitive impairment, and 81 healthy controls from January 2012 to December 2012. The real-time PCR was used to quantify miRNA107 and BACE1 mRNA. The power of classification accuracies between patients with amnestic mild cognitive impairment and healthy controls was performed using linear discriminate analysis single or combining both the expression miRNA107 and BACE1 mRNA. RESULTS For patients with Alzheimer's disease, the miRNA107 expressions in plasma and cerebral spinal fluid were correlated (Pearson correlation = 0.665, P = .034). There were statistically significant correlations between plasma miRNA107 and BACE1 mRNA gene expression in Alzheimer's disease, amnestic mild cognitive impairment, and healthy control groups (r value = -0.316 [P = .002], -0.615 [P < .001], and -0.367 [P = .001], respectively). The overall classification accuracy of miRNA107 to discriminate between patients with amnestic mild cognitive impairment and healthy controls was 91.9%, with sensitivity of 98.3% and specificity of 82.7%. CONCLUSIONS The miRNA107 expression in plasma has a high capability to discriminate between patients with amnestic mild cognitive impairment and healthy controls. TRIAL REGISTRATION ClinicalTrials.gov identifier: NCT01819545.
Recommendations for marketing campaigns in telecommunication business based on the footprint analysis: Who is a good client?

A major investment made by a telecom operator goes into the infrastructure and its maintenance, while business revenues depend on how efficiently it is exploited. We present a data-driven analytic strategy based on combinatorial optimization and analysis of historical data. The data cover historical mobility in one region of Sweden during a week. Applying the proposed method in a case study, we have identified the optimal combination of geodemographic segments in the customer base, developed a functionality to assess the potential of a planned marketing campaign, and investigated how many and which segments to target for customer base growth. A comprehensible summary of the conclusions is created via execution of the queries with a fuzzy logic component.
BitDrones: Towards Using 3D Nanocopter Displays as Interactive Self-Levitating Programmable Matter

We present BitDrones, a toolbox for building interactive real reality 3D displays that use nano-quadcopters as self-levitating tangible building blocks. Our prototype is a first step towards interactive self-levitating programmable matter, in which the user interface is represented using Catomic structures. We discuss three types of BitDrones: PixelDrones, equipped with an RGB LED and a small OLED display; ShapeDrones, augmented with an acrylic mesh spun over a 3D printed frame in a larger geometric shape; and DisplayDrones, fitted with a thin-film 720p touchscreen. We present a number of unimanual and bimanual input techniques, including touch, drag, throw and resize of individual drones and compound models, as well as user interface elements such as self-levitating cone trees, 3D canvases and alert boxes. We describe application scenarios and depict future directions towards creating high-resolution self-levitating programmable matter.
Understanding Position Transducer Technology for Strength and Conditioning Practitioners

STRENGTH AND POWER ASSESSMENTS IN CONDITIONING PRACTICE HAVE TYPICALLY INVOLVED RUDIMENTARY MEASURES SUCH AS 1 REPETITION MAXIMUM. MORE COMPLEX LABORATORY ANALYSIS HAS BEEN AVAILABLE BUT BECAUSE OF THE PRICE AND PORTABILITY OF EQUIPMENT, SUCH ANALYSIS REMAINED IMPRACTICAL TO MOST PRACTITIONERS. RECENTLY, A NUMBER OF DEVICES HAVE BECOME AVAILABLE THAT ARE REASONABLY INEXPENSIVE AND PORTABLE AND OFFER A GREAT DEAL OF INFORMATION THAT CAN BE USED TO GUIDE PROGRAMMING AND TRAINING TO BETTER EFFECT. ONE SUCH DEVICE IS THE LINEAR POSITION TRANSDUCER. THIS ARTICLE DISCUSSES THIS PIECE OF TECHNOLOGY FROM ITS DESIGN TO HOW IT MAY BE USED TO INFORM PRACTICE.
Prediction of Gold Price Based on WT-SVR and EMD-SVR Model

The current gold market show a high degree of nonlinearity and uncertainty, in order to predicted the gold price, Empirical Mode Decomposition (EMD) is introduced, the use the EMD orthogonal decompose the special functions into a finite number of independent intrinsic mode functions (IMFs), then Grouping the IMFs according different frequencies, using support vector regression (SVR) to predict each IMF group, at last plus each forecasting value of equal weighted will get the final prediction. Comparative analysis with the traditional practice is relatively mature wavelet transform (WT), WT decompose the function into some signal, then using SVR to predict detail signals and approximation signal, at last plus each forecasting parts will get the final prediction. Empirical studies show that: EMD has more accurate prediction than WT. This method provides a new powerful analytical tool for the gold price Prediction, an important guiding tool in theory and practice.
On the Interdependence of Language and Perception

It is argued that without a connection to the real world via perception, a language system cannot know what it is talking about. Similarly, a perceptual system must have ways of expressing its outputs via a language (spoken, written, gestural or other). The relationship between perception and language is explored, with special attention to the implications of results in language research for our models of vision systems, and viceversa. It is suggested that early language learning is an especially fertile area for this exploration. Within this area, we argue that perceptual data is conceptualized prior to language acquisition according to largely innate strategies, that this conceptualization is in terms of an internal, nonambiguous "language," that language production from its beginnings to adulthood is a <u>projection</u> of the internal language which selects and highlights the most important portions of internal concepts, and that schemata produced in the sensory/motor world are evolved into schemata to describe abstract worlds. Examples are provided which stress the important of "gestalt" (figure-ground) relationships and projection (3-D to 2--1/2 or 2-D, conceptual to linguistic, and linguistic to conceptual); finally mechanisms for an integrated vision-language system are proposed, and some preliminary results are described.
Effect of scaffold morphology and cell co-culture on tenogenic differentiation of HADMSC on centrifugal melt electrospun poly (L‑lactic acid) fibrous meshes

Engineered tendon grafts offer a promising alternative for grafting during the reconstruction of complex tendon tears. The tissue-engineered tendon substitutes have the advantage of increased biosafety and the option to customize their biochemical and biophysical properties to promote tendon regeneration. In this study, we developed a novel centrifugal melt electrospinning (CME) technique, with the goal of optimizing the fabrication parameters to generate fibrous scaffolds for tendon tissue engineering. The effects of CME processing parameters, including rotational speed, voltage, and temperature, on fiber properties (i.e. orientation, mean diameter, and productivity) were systematically investigated. By using this solvent-free and environmentally friendly method, we fabricated both random and aligned poly (L-lactic acid) (PLLA) fibrous scaffolds with controllable mesh thickness. We also investigated and compared their morphology, surface hydrophilicity, and mechanical properties. We seeded human adipose derived mesenchymal stem cells (HADMSC) on various PLLA fibrous scaffolds and conditioned the constructs in tenogenic differentiation medium for up to 21 days, to investigate the effects of fiber alignment and scaffold thickness on cell behavior. Aligned fibrous scaffolds induced cell elongation and orientation through a contact guidance phenomenon and promoted HADMSC proliferation and differentiation towards tenocytes. At the early stage, thinner scaffolds were beneficial for HADMSC proliferation, but the scaffold thickness had no significant effects on cell proliferation for longer-term cell culture. We further co-seeded HADMSC and human umbilical vein endothelial cells (HUVEC) on aligned PLLA fibrous mats and determined how the vascularization affected HADMSC tenogenesis. We found that co-cultured HADMSC–HUVEC expressed more tendon-related markers on the aligned fibrous scaffold. The co-culture systems promoted in vitro HADMSC differentiation towards tenocytes. These aligned fibrous scaffolds fabricated by CME technique could potentially be utilized to repair and regenerate tendon defects and injuries with cell co-culture and controlled vascularization.
Optimal control and operator based robust control for nonlinear system with output nonlinearity from sensor

In the application of smart actuators and sensors, there always exist non-smooth nonlinearities, which make system exhibit undesirable inaccuracies or oscillations and even instability owing to the undifferentiable and nonmemoryless characteristics. However, the non-smooth output nonlinearities brought about from sensors have always been ignored. In this paper, robust control for nonlinear system with output nonlinearities is considered. In details, the optimal control for general system with output constraint and operator based robust control for uncertain system with output nonlinear constraint using operator based internal model like control are considered respectively.
Wavelet Analysis to Detect Multi-scale Coherent Eddy Structures and Intermittency in Turbulent Boundary Layer

In the early stage of turbulence study, turbulent flow was deemed fully random and disorder motions of fluid particles. Thus physical quantity describing turbulence was considered as the composition of random fluctuations in spatial and temporal field. Reynoldsう1895えdivided the turbulent field into mean field and fluctuating field and then theories and methods based on statistics for turbulence research were developed. Kolmogorov[1] analyzed the relative motion of fluid particles in fully development isotropic and homogeneous turbulent flow based on random field theory and presented the concept of structure functions, which described the relative velocity of two fluid particles separated by distance of l , to investigate the statistical scaling law of turbulence:
Managing horses in groups to improve horse welfare and human safety

The aim of this thesis was to investigate whether specific anecdotal concerns related to keeping horses in groups are supported by science and, if so, provide scientifically based recommendations that could be implemented in practice. The aim of studies I and II was to identify methods for mixing unfamiliar horses that could minimise aggressive interactions and associated risk of injury. Results of study I revealed that pre-exposure of young horses in neighbouring boxes tended to lower contact-aggression (e.g. kicks, strikes) and biting behaviour in particular was reduced when the same pair of horses subsequently met in a paddock. This was not found when older horses were mixed (study II). Aggressive behaviour received by a new horse was not significantly different in meetings when it met one other horse compared to meeting two unfamiliar horses at the same time. Removing a horse from a group of four in study III was generally unproblematic. Most horses approached the handler when she was catching the horse and while standing with it in the middle of the paddock. Thus, potential risk may be higher in situations when the handler remains relatively stationary, as other horses of the group have time to approach. Rank did not influence the number of horses following to the paddock gate and interactions between horses were rare. Since horses naive to social separation may be more difficult to handle away from the group, the objective in study IV was to investigate whether the initial presence of a companion horse would modify responses to separation. Results revealed no significant differences in heart rates and the number of training sessions required when the horses were subsequently trained in the absence of the partner compared to horses trained alone from the start. In summary, results give little support for the original areas of concerns about mixing and separating horses. Risk of injury to both horses and humans should not be overestimated when handling horses in groups, but being aware of potential risk situations and being able to react accordingly is likely to increase horse welfare and human safety.
How MuCAR won the convoy scenario at ELROB 2016

Team MuCAR participated in the convoy scenario within the ELROB 2016 robotics trial and achieved the best score overall. This paper describes the hard- and software system of MuCAR, our new multi-sensor data fusion method as well as the challenging situations during the competition. The competition took place in an unstructured environment without lane markings and with dynamic objects. Autonomous following of a specific convoy leader and detecting hazardous environments in the form of ERICard associated warning signs were the main tasks of the convoy scenario. In order to achieve high robustness, we present a module which fuses the measurement data of different sensors and tracking modules at object level. In comparison to other participants, our team was able to drive the course without any manual interventions. Additionally, we were the only team which could detect all ERICards completely autonomously.
The YARHG Domain: An Extracellular Domain in Search of a Function

We have identified a new bacterial protein domain that we hypothesise binds to peptidoglycan. This domain is called the YARHG domain after the most highly conserved sequence-segment. The domain is found in the extracellular space and is likely to be composed of four alpha-helices. The domain is found associated with protein kinase domains, suggesting it is associated with signalling in some bacteria. The domain is also found associated with three different families of peptidases. The large number of different domains that are found associated with YARHG suggests that it is a useful functional module that nature has recombined multiple times.