Miracle-dz/UniFAR-FTUs huggingface dataset:
Traumatic brain injury: relationships between brain structural abnormalities and cognitive function

Traumatic brain injury (TBI) is the leading cause of disability in young adults and a major public health problem. Persistent cognitive impairments are common, and constitute a significant source of long-term disability. The specific pathophysiological mechanisms underlying these impairments remain poorly understood. As it disconnects brain networks, white matter damage can be a key determinant of cognitive impairment after TBI. Neuroimaging and neuropsychological methods were employed to explore the relationships between indices of brain structure and cognitive function. The participants were 40 TBI patients and 40 healthy controls. First, relationships between focal lesions and cognitive performance were investigated using structural magnetic resonance imaging (MRI) and a battery of neuropsychological tests. The results demonstrated that lesion location and load are not good indices of the cognitive deficits - probably because diffuse axonal injury is poorly assessed by standard MRI. By contrast, diffusion tensor imaging (DTI) can be used to quantify the microstructure of white matter. A ‘whole-brain’ technique, tract-based spatial statistics (TBSS), was used to flexibly analyse the structure of white matter tracts. Despite only small amounts of focal damage observed using standard MRI, TBSS revealed widespread white matter abnormalities after TBI. White matter damage was found in patients with no evidence of focal damage, and in patients classified as ‘mild’ clinically. Relationships between white matter tract structure and specific cognitive functions were then explored. The structure of the fornix, an important white matter pathway of the hippocampus, correlated with verbal associative memory across the patient and control groups. By contrast, structure of frontal lobe connections showed distinct relationships with executive function in these two groups. The results emphasise the importance of white matter pathology after TBI and suggest that disruption to specific white matter tracts is associated with particular patterns of cognitive impairment, but also highlight the complexity of these relationships.
Relation between habitual sleep duration and depressed mood state: Somatic versus cognitive symptoms

The present ex post facto prospective investigation analyses the association between habitual sleep duration and depressed mood state in college students. The sample was composed of 141 healthy students of both sexes, 19 with short sleep pattern (sleeping 6 hours or less per night), 64 with intermediate sleep pattern (sleeping 7-8 hours per night) and 58 with long sleep pattern (sleeping more than 9 hours per night). Depressed mood was evaluated with the Becks Depression Inventory (BDI) and the depression subscale of the General Health Questionnaire (GHQ-28). The scores for depressed mood state were higher for individuals with short and long sleep pattern than for those with intermediate sleep pattern. The item analysis of specific depression symptoms indicated that short sleepers differ from intermediate sleepers in the somatic symptoms of depressed mood, whereas the differences between long and intermediate sleepers are observed in cognitive aspects. Some explicative hypothesis about the mechanisms that could be mediating relations between sleep duration and depressed mood are discussed. The development of educational initiatives destined to optimise students' sleep habits may be useful to prevent future depression.
Mutational analysis of the conserved cysteine-rich region of the human immunodeficiency virus type 1 Tat protein

The Tat transactivator protein of human immunodeficiency virus type 1 contains a highly conserved cysteine-rich region, containing seven cysteines from residues 22 through 37. To investigate the importance of noncysteine residues in this region of the Tat protein, we have carried out a mutational analysis, in most cases substituting a single alanine for the wild-type noncysteine residue. Alanine substitution of residue 23, 24, 46, or 47 had no effect on Tat activity in plasmid transfection assays. In contrast, alanine substitutions of all eight noncysteines analyzed, from residues 26 through 41, significantly reduced the activity of the Tat protein, in some cases as drastically as mutations in cysteine residues. The results demonstrate that the precise sequence of the cysteine-rich region is crucial for a fully functional Tat protein.
Usefulness of a Helicobacter pylori stool antigen test for diagnosing H. pylori infected C57BL/6 mice

Among several diagnostic tests, a Helicobacter pylori stool antigen (HpSA) test may offer a useful noninvasive method for diagnosing infection without sacrificing animals. In this study, male C57BL/6 mice (n=6) were infected with H. pylori ATCC 49503 (1×108 CFU/mouse) by intragastric inoculation three times at 2-day intervals, and H. pylori infected stool specimens were collected 1, 3, 5, 7, 14, 21 days after infection to assess reliability of the HpSA test. Five of six specimens were positive at 5-21 days after infection, and the sensitivity of the HpSA test was 83.33%. The presence of H. pylori infection was confirmed by the rapid urease test and genomic DNA polymerase chain reaction (PCR), and showed the same results as the HpSA. However, the rapid urease test and genomic DNA PCR are invasive tests and require animal sacrifice to detect H. pylori in gastric biopsy samples. We suggest that an HpSA test kit would be useful and effective for monitoring H. pylori in various laboratory animals, as H. pylori can be easily monitored without sacrificing animals.
Chromothripsis-like chromosomal rearrangements induced by ionizing radiation using proton microbeam irradiation system

Chromothripsis is the massive but highly localized chromosomal rearrangement in response to a one-step catastrophic event, rather than an accumulation of a series of subsequent and random alterations. Chromothripsis occurs commonly in various human cancers and is thought to be associated with increased malignancy and carcinogenesis. However, the causes and consequences of chromothripsis remain unclear. Therefore, to identify the mechanism underlying the generation of chromothripsis, we investigated whether chromothripsis could be artificially induced by ionizing radiation. We first elicited DNA double-strand breaks in an oral squamous cell carcinoma cell line HOC313-P and its highly metastatic subline HOC313-LM, using Single Particle Irradiation system to Cell (SPICE), a focused vertical microbeam system designed to irradiate a spot within the nuclei of adhesive cells, and then established irradiated monoclonal sublines from them, respectively. SNP array analysis detected a number of chromosomal copy number alterations (CNAs) in these sublines, and one HOC313-LM-derived monoclonal subline irradiated with 200 protons by the microbeam displayed multiple CNAs involved locally in chromosome 7. Multi-color FISH showed a complex translocation of chromosome 7 involving chromosomes 11 and 12. Furthermore, whole genome sequencing analysis revealed multiple de novo complex chromosomal rearrangements localized in chromosomes 2, 5, 7, and 20, resembling chromothripsis. These findings suggested that localized ionizing irradiation within the nucleus may induce chromothripsis-like complex chromosomal alterations via local DNA damage in the nucleus.
Association of Polymorphisms in the Bovine Leptin Gene with Ultrasound Measurements for Improving in Korean Cattle

The identification method that inflects real time ultrasound (RUT) and the potential application of marker assisted selection (MAS) for improvement of a cow population of Hanwoo (Korean Native cattle) was studied. The averages of RUT longissimus muscle area, RUT fat thickness, and RUT marbling score scanned at the 13th rib were 55.78 cm 2 , 3.70 mm and 3.83 scores, respectively. We investigated the effccts of the two SNPs (Kpn2 1 and Msp 1) in the leptin gene on carcass traits for Hanwoo cows by using ultrasound measurements. Genotype CC of the Kpn2 I had a significantly higher effect on back fat thickness (4.23 mm) and longissimus muscle area (57.57 cm 2 ) than genotype TT (3.14 mm, 53.93 cm 2 , respectively, p<0.05). Genotype AA of the Msp I had a significantly higher effect only on marbling score (5.37) than genotype AB (3.57, p<0.05) and BB (3.37, p<0.05). Significant effects of SNPs in the leptin gene were found for the ultrasound measures of body composition in live cattle.
Hips with synovial chondromatosis may display the features of femoroacetabular impingement.

BACKGROUND Both synovial chondromatosis and femoroacetabular impingement present with hip pain and may lead to hip osteoarthritis. We present a small case series and describe the clinical presentation, investigation, and treatment of patients with synovial chondromatosis who also had cam-type femoroacetabular impingement involving the same hip. METHODS Five patients (four men and one woman with a mean age of thirty-four years [range, thirty to thirty-seven years]) with unilateral synovial chondromatosis of the hip presented with clinical and radiographic features of ipsilateral cam-type femoroacetabular impingement. The diagnosis of associated synovial chondromatosis was made on the basis of preoperative imaging in four of the cases. All patients were treated with surgical hip dislocation, excision of the synovial chondromatosis loose bodies, and reshaping of the femoral head-neck junction. RESULTS These hips exhibited radiographic features that are not typically seen with idiopathic cam-type femoroacetabular impingement, including femoral head hypertrophy, lateralization of the femoral head, and haziness in the acetabular fossa. None of the hips showed signs of advanced osteoarthritis intraoperatively. The alpha angle improved from a mean of 72.4° preoperatively to 42.6° postoperatively. At a mean of twenty-two months of follow-up, the patients had a mean Harris hip score of 80.6, substantially improved from the preoperative value of 39. CONCLUSIONS Hips with synovial chondromatosis may present with clinical and radiographic features resembling those of cam-type femoroacetabular impingement. As simultaneous treatment of both conditions is best accomplished with surgical hip dislocation rather than other, less-extensive surgical approaches, we recommend preoperative consideration of synovial chondromatosis in patients presenting with unilateral cam-type femoroacetabular impingement.
Organisational memory and CSCW: supporting the 'Mavis Phenomenon'

Organisational Memory is concept which has gained some currency in recent years. The aim of this paper is to query the conceptual underpinnings of the notion. An alternative and more social conception of the kind of phenomena 'organisational memory' points to is offered one which connects more thoroughly with 'remembering activities' as practical accomplishments of organisational life.
Music recommendation system based on user's sentiments extracted from social networks

In recent years, the sentiment analysis has been explored by several Internet services to recommend contents in accordance with human emotions, which are expressed through informal texts posted on social networks. However, the metrics used in the sentiment analysis only classify a sentence with positive, neutral or negative intensity, and do not detect sentiment variations in accordance with the user's profile. In this arena, this paper presents a music recommendation system based on a sentiment intensity metric, named enhanced Sentiment Metric (eSM) that is the association of a lexicon-based sentiment metric with a correction factor based on the user's profile. This correction factor is discovered by means of subjective tests, conducted in a laboratory environment. Based on the experimental results, the correction factor is formulated and used to adjust the final sentiment intensity. The users' sentiments are extracted from sentences posted on social networks and the music recommendation system is performed through a framework of low complexity for mobile devices, which suggests songs based on the current user's sentiment intensity. Also, the framework was built considering ergonomic criteria of usability. The performance of the proposed framework is evaluated with remote users using the crowdsourcing method, reaching a rating of 91% of user satisfaction, outperforming a randomly assigned song suggestion that reached 65% of user satisfaction. Furthermore, the paper presents low perceived impacts on the analysis of energy consumption, network and latency in accordance with the processing and memory perception of the recommendation system, showing advantages for the consumer electronic world.
[3H]Adenosine Triphosphate: Release during Stimulation of Enteric Nerves

The isolated taenia coli of the guinea pig takes up tritiated adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate, in preference to tritiated inosine and adenine. After uptake, [3H]adenosine is converted and retained primarily as [3H]adenosine triphosphate. Tritium is released from taenia coli treated with [3H]adenosine upon activation of the nonadrenergic inhibitory nerves. These results are consistent with the previous evidence that adenosine triphosphate may be the transmitter from the nerves.
Performance Modeling and Simulation of Microstrip Dipole Array Antenna for WLAN Application

This paper proposed a performance simulation of a two-element, microstrip dipole array antenna for WLAN application. Simulation is done using two different simulation techniques, the circuit model (CM) derived from the transmission line model (TLM), and is compared with another simulation set using the Method of Moments (MoM). Both methods are simulated using Microwave Office. The basic microstrip dipole antenna is accurately modeled and the linear array structure is done by combining two basic units. Both simulation sets of MoM and CM are evaluated to determine their level of variation in terms of return loss (Su), bandwidth and resonant frequency (fres). The MoM designed for dipole antennas achieved the best return loss (Su), bandwidth and resonant frequency fres) at the desired frequency. The equivalent circuit proposed produced good return loss and comparable with simulation using MoMs. Details of the proposed antenna design and simulation results for 2.45 GHz WLAN band are presented and deliberated.
Dynamic time-aware attention to speaker roles and contexts for spoken language understanding

Spoken language understanding (SLU) is an essential component in conversational systems. Most SLU component treats each utterance independently, and then the following components aggregate the multi-turn information in the separate phases. In order to avoid error propagation and effectively utilize contexts, prior work leveraged history for contextual SLU. However, the previous model only paid attention to the content in history utterances without considering their temporal information and speaker roles. In the dialogues, the most recent utterances should be more important than the least recent ones. Furthermore, users usually pay attention to 1) self history for reasoning and 2) others utterances for listening, the speaker of the utterances may provides informative cues to help understanding. Therefore, this paper proposes an attention-based network that additionally leverages temporal information and speaker role for better SLU, where the attention to contexts and speaker roles can be automatically learned in an end-to-end manner. The experiments on the benchmark Dialogue State Tracking Challenge 4 (DSTC4) dataset show that the time-aware dynamic role attention networks significantly improve the understanding performance1.
Cost-Efficient Wireless Mobile Backhaul Topologies: An Analytical Study

Wireless communication technologies such as microwave radios are used to provide high-speed mobile backhaul connectivity for radio access networks in cases in which wire-based alternatives, e.g. cable or fiber, are not readily available and cannot be deployed in an economic or timely manner. Current mobile backhauls are predominantly deployed in tree or ring topologies, which simplify traffic management. Yet, with the increasing demand on backhaul capacity and the immense cost pressure on mobile backhaul solutions, meshed wireless mobile backhauls have been identified as a promising evolution. While traffic management in wireless mesh networks have been studied extensively in the literature, so far there is no quantitative analysis comparing the different topology options, i.e. mesh, ring and tree, regarding network performance and deployment cost. This paper fills this gap by studying the minimum cost problem of connecting a set of base station/gateway sites using different topologies while supporting both time- and space-varying traffic demands. Furthermore, we consider the additional constraint of resilience to single link failures. The evaluation results show that meshed wireless backhaul topologies are a cost-effective alternative to trees and rings, in particular in the face of spatial and temporal fluctuation of traffic demand and protection against link failures.
Sketch-based Image Retrieval from Millions of Images under Rotation, Translation and Scale Variations

Proliferation of touch-based devices has made sketch-based image retrieval practical. While many methods exist for sketch-based object detection/image retrieval on small datasets, relatively less work has been done on large (web)-scale image retrieval. In this paper, we present an efficient approach for image retrieval from millions of images based on user-drawn sketches. Unlike existing methods for this problem which are sensitive to even translation or scale variations, our method handles rotation, translation, scale (i.e. a similarity transformation) and small deformations. The object boundaries are represented as chains of connected segments and the database images are pre-processed to obtain such chains that have a high chance of containing the object. This is accomplished using two approaches in this work: a) extracting long chains in contour segment networks and b) extracting boundaries of segmented object proposals. These chains are then represented by similarity-invariant variable length descriptors. Descriptor similarities are computed by a fast Dynamic Programming-based partial matching algorithm. This matching mechanism is used to generate a hierarchical k-medoids based indexing structure for the extracted chains of all database images in an offline process which is used to efficiently retrieve a small set of possible matched images for query chains. Finally, a geometric verification step is employed to test geometric consistency of multiple chain matches to improve results. Qualitative and quantitative results clearly demonstrate superiority of the approach over existing methods.
Event Extraction in a Plot Advice Agent

In this paper we present how the automatic extraction of events from text can be used to both classify narrative texts according to plot quality and produce advice in an interactive learning environment intended to help students with story writing. We focus on the story rewriting task, in which an exemplar story is read to the students and the students rewrite the story in their own words. The system automatically extracts events from the raw text, formalized as a sequence of temporally ordered predicate-arguments. These events are given to a machine-learner that produces a coarse-grained rating of the story. The results of the machine-learner and the extracted events are then used to generate fine-grained advice for the students.
Arabidopsis SH 3 P 2 is an ubiquitin-binding protein that functions together with ESCRT-I and the deubiquitylating enzyme AMSH 3

Chair of Plant Physiology and Biochemistry, Department of Biology, University of Konstanz, 78457 Konstanz, Germany; Chair of Plant Systems Biology, School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising, Germany; Department of Biochemistry, University of Wisconsin– Madison, Madison, WI 53706; Chair of Proteomics and Bioanalytics, School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising, Germany; Department of Life and Environmental Sciences, Kyoto Prefectural University, 606-0823 Kyoto, Japan; and Department of Botany, National Museum of Nature and Science, 305-0005 Tsukuba, Japan
Gaze Strategy in the Free Flying Zebra Finch (Taeniopygia guttata)

Fast moving animals depend on cues derived from the optic flow on their retina. Optic flow from translational locomotion includes information about the three-dimensional composition of the environment, while optic flow experienced during a rotational self motion does not. Thus, a saccadic gaze strategy that segregates rotations from translational movements during locomotion will facilitate extraction of spatial information from the visual input. We analysed whether birds use such a strategy by highspeed video recording zebra finches from two directions during an obstacle avoidance task. Each frame of the recording was examined to derive position and orientation of the beak in three-dimensional space. The data show that in all flights the head orientation was shifted in a saccadic fashion and was kept straight between saccades. Therefore, birds use a gaze strategy that actively stabilizes their gaze during translation to simplify optic flow based navigation. This is the first evidence of birds actively optimizing optic flow during flight.
Temporary Balloon Occlusion of the Common Hepatic Artery for Yttrium-90 Glass Microspheres Administration in a Patient with Hepatocellular Cancer and Renal Insufficiency

The most severe complication of yttrium-90 therapy is gastrointestinal ulceration caused by extrahepatic dispersion of microspheres. Standard pretreatment planning requires extensive angiographic evaluation of the hepatic circulation and embolization of hepatoenteric collaterals; however, in patients with severe renal insufficiency, this evaluation may lead to acute renal failure. In order to minimize iodinated contrast utilization in a patient with preexisting severe renal insufficiency, the authors describe the use of a balloon catheter for temporary occlusion of the common hepatic artery to induce transient redirection of flow of the hepatoenteric arteries towards the liver, in lieu of conventional coil embolization.
Driver Drowsiness Detection System and Techniques : A Review

Drivers who do not take regular breaks when driving long distances run a high risk of becoming drowsy a state which they often fail to recognize early enough according to the experts. Studies show that around one quarter of all serious motorway accidents are attributable to sleepy drivers in need of a rest, meaning that drowsiness causes more road accidents than drink-driving. Attention assist can warn of inattentiveness and drowsiness in an extended speed range and notify drivers of their current state of fatigue and the driving time since the last break, offers adjustable sensitivity and, if a warning is emitted, indicates nearby service areas in the COMAND navigation system. Keywords—Drowsiness Detection, Eyes Detection, Blink Pattern, Face Detection, LBP, SWM.