Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of a Multi-Household Version of the MONASH Model

This paper is ongoing work by the Centre of Policy Studies and the Impact Project that integrates the ideas of micro simulation with Computable General Equilibrium (CGE) modelling. In micro simulation the behaviour of individuals or households is modelled directly, typically using unit record data, whereas CGE models place an emphasis on market interactions and can take account of the indirect effect on households of changes in market conditions. For many policy issues (such as taxation reform), a combination of the two approaches is desirable so that both the direct and the indirect effects of such reform can be addressed. What is needed is for unit record data to be used in combination with a CGE model; that is, for the modelling of households to be combined with the modelling of markets. This can be achieved by embedding a detailed household sector in an CGE model. The solution of the model then provides distributional results for the representative households directly. In this paper a detailed household sector comprising 100 types of households — differentiated by income and demographic grouping — is developed and embedded in the MONASH Model. Simulations are conducted that measure the economy wide effects of redistributing income across these households.
Mood parameters and severe physical symptoms of the female reproductive cycle.

OBJECTIVE The cyclic variation of physical and psychological phenomena has been accepted as a natural consequence of the cyclicity of the human female reproductive function. The exact nature of these changes, however, has not been fully understood. The aim of our study was to investigate the fluctuation of psychological and physical symptoms throughout the female reproductive cycle in healthy, non-PMDD women. METHOD 63 psychiatrically healthy, non-PMDD women with normal regular menstrual cycles and not using hormonal contraceptive methods participated in the study. Participants completed the PRISM calendar every night for three consecutive cycles and on three predefined days of the first cycle they completed several other psychometric measures (SCL-51, STAI, ZSDS, EAT and Mind and Body Cathexis Scale). Based on an at least 66% increase in physical symptoms from the late follicular to the late luteal phase on the PRISM, subjects were assigned to LPPS (luteal phase physical symptoms) and nonLPPS (no luteal phase physical symptoms) groups. Average of psychometric scores obtained at the three predefined days were compared between the two groups. RESULTS There was a significant difference between the two groups only in case of the interpersonal sensitivity subscale of the SCL-51. CONCLUSION Our results indicate that the appearance of severe physical symptoms in the late luteal phase of the female reproductive cycle is not accompanied by a worsening of psychological symptoms. The appearance of enhanced psychological symptomatology attributed to the luteal phase of the female reproductive cycle thus seems to be independent of the appearance of severe physical symptoms.
Diagnostic accuracy of bedside tests for predicting difficult intubation in Indian population: An observational study

Background: Unanticipated difficult intubation can be challenging to anesthesiologists, and various bedside tests have been tried to predict difficult intubation. Aims: The aim of this study was to determine the incidence of difficult intubation in the Indian population and also to determine the diagnostic accuracy of bedside tests in predicting difficult intubation. Settings and Design: In this study, 200 patients belonging to age group 18–60 years of American Society of Anesthesiologists I and II, scheduled for surgery under general anesthesia requiring endotracheal intubation were enrolled. Patients with upper airway pathology, neck mass, and cervical spine injury were excluded from the study. Materials and Methods: An attending anesthesiologist conducted preoperative assessment and recorded parameters such as body mass index, modified Mallampati grading, inter-incisor distance, neck circumference, and thyromental distance (NC/TMD). After standard anesthetic induction, laryngoscopy was performed, and intubation difficulty assessed using intubation difficulty scale on the basis of seven variables. Statistical Analysis: The Chi-square test or student t-test was performed when appropriate. The binary multivariate logistic regression (forward-Wald) model was used to determine the independent risk factors. Results: Among the 200 patients, 26 patients had difficult intubation with an incidence of 13%. Among different variables, the Mallampati score and NC/TMD were independently associated with difficult intubation. Receiver operating characteristic curve showed a cut-off point of 3 or 4 for Mallampati score and 5.62 for NC/TMD to predict difficult intubation. Conclusion: The diagnostic accuracy of NC/TM ratio and Mallampatti score were better compared to other bedside tests to predict difficult intubation in Indian population.
The debridement of hard to heal leg ulcers by means of a new device based on Fluidjet technology

Debridement plays an essential role in the wound‐bed preparation of necrotic and sloughy ulcers, being a mandatory step to achieve a well‐debrided bed, proceeding towards healing. This study reports our experience with Versajet [Versajet Hydrosurgery System® (Smith & Nephew, Hull, UK)], a new device for the debridement of exudating ulcers, based on Fluidjet technology, which excises and aspirates the unwanted tissue by using the Venturi effect. In a 10‐month time period, a total of 68 patients, out of a setting of 167 patients, hospitalised as affected by chronic, hard‐to‐heal leg ulcers, stuck in the inflammatory phase, were treated with Versajet. Based on ulcer characteristics and clinical conditions, the remaining 99 patients underwent traditional debridement with moist dressings (controls). In the majority of Versajet‐treated cases (46), an adequately debrided wound bed was achieved with one operative procedure; two and three procedures were required in 17 and 5 patients, respectively. Almost all the procedures were performed in the ward at the patient's bedside. This procedure is quick (mean time per treatment is about 5 minutes); when compared with a traditional treatment with moist dressings, Versajet considerably shortens the in‐hospital stay and promotes a quicker healing process. When used by an experienced surgeon, Versajet allows a selective debridement, as it makes it possible to remove only the tissue centred in the working end and spare the healthy tissue. Debriding with Versajet is highly effective in reducing the bacterial load of the ulcer bed. The pain caused by Versajet is well tolerated, especially when set for gentle debridement. If multiple treatments are required, the combined use with moist dressings is synergistic, as the dressings soften the necrotic tissue, thus facilitating the following Versajet debridement. The results indicate that Versajet offers more precision than standard mechanical debridement and, at high settings, offers an alternative to surgical debridement.
Brain involvement in muscular dystrophies with defective dystroglycan glycosylation

To assess the range and severity of brain involvement, as assessed by magnetic resonance imaging, in 27 patients with mutations in POMT1 (4), POMT2 (9), POMGnT1 (7), Fukutin (4), or LARGE (3), responsible for muscular dystrophies with abnormal glycosylation of dystroglycan (dystroglycanopathies).
Internal thermodynamics of position 51 mutants and natural variants of tyrosyl-tRNA synthetase.

Natural variation and evolution impose structural changes on an enzyme that can affect the energetics of catalysis. The energy profile of reaction could, in theory, be altered in three distinct ways: uniform binding changes, differential binding changes, and catalysis of elementary steps. Residue threonine-51 of tyrosyl-tRNA synthetase from Bacillus stearothermophilus is subject to natural variation, being replaced by alanine and proline in the enzymes from Bacillus caldotenax and Escherichia coli, respectively. The consequences of this variation on the energetics of formation of tyrosyl adenylate have been investigated by constructing free energy profiles for wild-type and mutant enzymes constructed by introducing these amino acids into the B. stearothermophilus enzyme. Mutation of Thr-51 to alanine, proline, and cysteine by site-directed mutagenesis improves the stabilization of the transition state in the formation of tyrosyl adenylate. Most marked is the mutation Thr-51----Pro-51 which stabilizes the transition state by 2.2 kcal/mol and accelerates the forward rate 20-fold to a level near that of the enzyme from E. coli. However, the improved transition-state binding is accompanied by an even greater stabilization of tyrosyl adenylate. This reduces the rate of pyrophosphorolysis of tyrosyl adenylate and/or weakens the binding of pyrophosphate in the reverse reaction, shifting the equilibrium between enzyme-bound reactants greatly in favor of the enzyme-intermediate complex. The more stable mutant enzyme-tyrosyl adenylate complexes have lower rates of aminoacylation, suggesting that mutations which stabilize the intermediate slow down the subsequent transfer of tyrosine from tyrosyl adenylate to tRNA. (ABSTRACT TRUNCATED AT 250 WORDS)
The Influence of Information Presentation and Online Trust in the C2C Web Store Context

When consumer are shopping online, the information of web store is very important for them. For consumer, the web stores present their information in three forms: factual information, evaluative information and warranty information. This paper employs the field study in the C2C web store context to show that the information presentation has a positive effect on online trust and consumer's willingness to buy , and the product category mediates the relationship between information presentation and online trust.
Empirical Methods for Detecting Bid-rigging Cartels

Le projet de these presente differentes methodes empiriques permettant de detecter des cartels. Il vise a demontrer premierement que des resultats efficaces peuvent etre obtenus avec de simples indicateurs statistiques et deuxiemement que les methodes econometriques traditionnelles ne sont pas aussi efficaces.
Intra-arterial thrombolysis in the carotid territory

Stroke is the third-leading cause of death and the lead-ing cause of adult disability in the industrialized world.The only efficacious and approved treatment option foracute ischaemic stroke (AIS) is intravenous recombinanttissue plasminogen activator (r-tPA), administered with-in 3 hours after symptom onset (1). This short time win-dow significantly limits the proportion of treatablepatients. Public campaigns can enhance patient recruit-ment up to 10%. This means we are still in need for ananswer for the patients presenting too late to be treatedwithin this limit. The only treatment option for AIS thatshowed a benefit up to 6 hours after symptom onset in arandomised controlled trial is intra-arterial thrombolysis(IAT) with recombinant pro-urokinase (2). Otherpatients that could benefit from IAT are those with con-tra-indications for intravenous thrombolysis (IVT)(Fig. 1) and those that are less likely to respond to sys-temic thrombolysis, such as patients with large vesselocclusions. Potential advantages of IAT are not only anextended time window and the titration of the medica-tion dose to avoid systemic effects, but also, and maybemost off all, that it can be combined with a kind ofmechanical thrombolysis. Disadvantages are that theextended time window is at least in part offset by thetime to perform the arteriography, the need for more per-sonal and technical resources and finally some specificcomplications such as groin haematoma or cerebralembolism provoked by manipulation of the catheter.
Cholecystokinin-like immunoreactive amacrine cells in the rat retina

High levels of endogenous cholecystokinin (CCK) are present in the rat retina (Eskay & Beinfeld, 1982), but the cellular localization and physiological actions of CCK in the rat retina are uncertain. The goals of this study were to characterize the cells containing CCK, identify cell types that interact with CCK cells, and investigate the effects of CCK on rod bipolar cells. Rat retinas were labeled with antibody to gastrin-CCK (gCCK) using standard immunofluorescence techniques. Patch-clamp methods were used to record from dissociated rod bipolar cells from rats and mice. Gastrin-CCK immunoreactive (-IR) axons were evenly distributed throughout the retina in stratum 5 of the inner plexiform layer of the rat retina. However, the gCCK-IR somata were only detected in the ganglion cell layer in the peripheral retina. The gCCK-IR cells contained glutamate decarboxylase, and some of them also contained immunoreactive substance P. Labeled axons contacted PKC-IR rod bipolar cells, and recoverin-IR ON-cone bipolar cells. CCK-octapeptide inhibits GABAC but not GABAA mediated currents in dissociated rod bipolar cells.
Biochemistry students' ideas about shape and charge in enzyme–substrate interactions

Biochemistry is a visual discipline that requires students to develop an understanding of numerous representations. However, there is very little known about what students actually understand about the representations that are used to communicate ideas in biochemistry. This study investigated biochemistry students' understanding of multiple representations of enzyme–substrate interactions through both student interviews (N = 25) and responses by a national sample (N = 707) to the Enzyme–Substrate Interactions Concept Inventory. This manuscript reports the findings regarding one category of misconceptions measured by the concept inventory, namely, students' understandings of shape and charge in the context of enzyme–substrate interactions. Students interpret molecular representations depicting such interactions by determining the complementarity between enzyme and substrate by focusing upon charge and hydrogen bonding, but with a disregard for stereochemistry. © 2014 by The International Union of Biochemistry and Molecular Biology, 42(3):XXXXX–XXXXX, 2014.
Chemoreceptor activity is normal in mice lacking the NK1 receptor

Substance P has been proposed to be an important neurotransmitter in the carotid body with the neurokinin 1 (NK1) receptor, mediating excitation between the glomus cells and afferent nerve endings. In order to better understand the role of substance P, this study examined chemoreceptor afferent activity, in vitro, and tissue catecholamine levels and release in adult, wild‐type mice and mice lacking the gene for the NK1 receptor (NK1‐KO). Groups did not differ significantly in body weight, carotid body dopamine content or carotid body norepinephrine content. In wild‐type mice, single unit activity increased from 0.59 ± 0.14 Hz to 19.78 ± 2.27 Hz during superfusion with strong hypoxia (PO2 ≈ 25 Torr). Chemoreceptor activity in NK1‐KO mice, increased from 0.71 ± 0.23 to 21.50 ± 3.62 Hz, and neither baseline or peak frequencies were significantly different from the wild‐type group. Less severe hypoxia (PO2≈ 45 torr), evoked peak activities of 12.50 ± 1.88 and 10.64 ± 3.72 Hz in wild‐type and NK1‐KO mice, which were also not significantly different. In response to severe hypoxia, free‐tissue catecholamine increased to 4.92 ± 0.85 µm in wild‐type mice and 4.26 ± 0.63 µm in NK1‐KO mice, which were also not significantly different. It may therefore be concluded that loss of NK1 receptors has little effect on chemoreceptor function in the mouse, and thus they play, at best, a minor role in the hypoxic chemoreception process.
Disrupting governance with blockchains and smart contracts

Blockchain as an engine for auto-enforceable smart contracts could disrupt traditional governance structures by reducing bureaucracy through lower transaction costs, solving principal–agent issues, and subsequent moral hazard. While machine consensus can radically reduce transaction costs and disrupt traditional governance structures, there is a gap between initial conceptualizations of blockchains and their first instantiations. First use cases show that as circumstances change, protocols can become inappropriate for the new environment and require modification. Modification of blockchain code happens through majority consensus, but reaching consensus in a distributed multi-stakeholder network with sometimes unaligned interests is complex, potentially introducing new agency issues.
Fluorescence lifetime‐based discrimination and quantification of cellular DNA and RNA with phase‐sensitive flow cytometry

Simultaneous measurement of cellular DNA and RNA content provides information for determination of the functional status of cells and, clinically, for the diagnosis and grading assessment of various tumors. Most current flow cytometric methods are based on resolving the fluorescence emission spectra of dyes that bind preferentially to either type of nucleic acid. However, several monochromatic nucleic acid–binding fluorochromes display resolvable differences in fluorescence lifetime when bound to DNA or RNA. The differences in the lifetime of one fluorescent probe provide an alternate means to distinguish the binding of one probe to these cellular macromolecules and to simultaneously measure their cellular contents.
Propagation-Based Biclustering Algorithm for Extracting Inclusion-Maximal Motifs

Biclustering, which is simultaneous clustering of columns and rows in data matrix, became an issue when classical clustering algorithms proved not to be good enough to detect similar expressions of genes under subset of conditions. Biclustering algorithms may be also applied to different datasets, such as medical, economical, social networks etc. In this article we explain the concept beneath hybrid biclustering algorithms and present details of propagation-based biclustering, a novel approach for extracting inclusion-maximal gene expression motifs conserved in gene microarray data. We prove that this approach may successfully compete with other well-recognized biclustering algorithms.
Multi-agent platform for development of educational games for children with autism

Multi-agent system of autonomous interactive blocks that can display its active state through color and light intensity has been developed. Depending on the individual rules, these autonomous blocks could express emergent behaviors which are a basis for various educational games. The multi-agent system is used for developing games for behavioral training of autistic children. This paper features the functional and electronic design of the individual blocks and transformation of the multi-agent system to a platform that allows multiple games to be designed through easy reprogramming of the blocks. Three game concepts that show the type of games that can easily be implemented and reprogrammed are described. The impact of this platform is shortly mentioned in the discussion. The initial tests of using the platform for various educational games are very positive. However, the results of user tests go beyond the scope of this paper and are not discussed in the text that follows.
Detection and Quantification of Genetically Modified Soybean in Some Food and Feed Products. A Case Study on Products Available on Romanian Market

The aim of this paper is to trace genetically modified soybean in food and feed products present on the Romanian market by using molecular extraction, identification and quantification methodologies. Nine samples (3 food samples, 5 soybean samples and 1 soybean meal) were analysed using the classical and real-time polymerase chain reaction (PCR) method. DNA-genetically modified organism (GMO) was not detected in two of the three analysed samples (food products). However, it could be found in four samples ranging below the limit of 0.9%, and in three samples, above the limit of 0.9%. The results obtained through real-time PCR quantification show that DNA-RRS was detectable in different amounts in different samples: ranging between 0.27% and 9.36% in soy beans, and reaching 50.98% in soybean meal. The current research focuses on how products containing GMO above the limit (it is common knowledge that it is necessary to label the products containing more than 0.9% Genetically Modified DNA) are differentiated on the market with a view to labeling food and feed products in terms of the accidental presence of approved genetically modified plants. The benefits brought by genetic engineering in obtaining genetically modified organisms can be balanced with their public acceptance and with certain known or unknown risks that they can bring.
Antidiabetic potential of triterpenoid saponin isolated from Primula denticulate

Abstract Context: Primula denticulate Sm. (Primulaceae), commonly known as drumstick primula, is traditionally used to treat diabetes and urinary disorders. In the present study, a new triterpenoid saponin was isolated. Triterpenoids generally show antidiabetic activity. Considering its traditional use and chemical nature of the molecule, the present study was designed to evaluate the antidiabetic activity. Objective: Antidiabetic activity of triterpenoid saponin (TTS) isolated from P. denticulate. Materials and methods: A new TTS was isolated from the leaf of P. denticulate by column chromatography on CHCl3/MeOH (8.5:1.5) fraction. It was further characterized by using NMR, UV, and IR spectroscopic methods. Ethanol and aqueous extracts of the leaf were also prepared. Antidiabetic study for TTS, ethanol extract, and aqueous extract was carried out in streptozotocin (STZ)-induced diabetic rats at doses of 200, 1000, and 1000 mg/kg body weight, respectively. A toxicity study was also performed. Results: Isolated new TTS molecule was characterized as 3-O[β-d-xylopyranosyl-(1 → 2)-β-d-glucopyranosyl-(1 → 4)-α-l-arabinopyranosyloxy]-16α-hydroxy-13β,28-epoxy-olean-30-al by NMR, UV, and IR spectroscopic methods. This new TTS was found to be effective in lowering blood-glucose level in the experimental rat model, thus establishing its antidiabetic property (168.8 ± 4.58) when compared with disease control (258.8 ± 0.60). Its LD50 value was found at a dose of 2000 mg/kg. The level of insulin was restored by TTS and ethanol extract up to 31.49 µU/ml and 38.90 µU/ml, respectively, when compared with disease control (18.45 µU/ml). Discussion and conclusion: In conclusion, 3-O[β-d-xylopyranosyl-(1 → 2)-β-d-glucopyranosyl-(1 → 4)-α-l-arabinopyranosyloxy]-16α-hydroxy-3β,28-epoxy-olean-30-al possesses potential glucose lowering properties, i.e., antidiabetic potential against STZ-induced diabetic rats.
Research on Early Warning Control of University Budget Process Risk Based on Naive Bayes

—With the implementation of budget management in universities, some good results have been achieved. However, there are some problems in the course of operation, such as how to find out the risks in the course of budget project implementation and judge the risk level, and then take action effectively. This paper constructs the relevant indicators of budget risk early warning in universities. The indicators are mainly classified from the inside and outside the risk factors of the universities. Then the classification of the indicators is carried out by using naive Bayes in R language. It proved that the construction of these indicators can be used in universities budget process control in early warning, so that managers can timely detect the risk factors and take appropriate measures.