Miracle-dz/UniFAR-FTUs huggingface dataset:
Tumor Classification and Segmentation of MR Brain Images

The diagnosis and segmentation of tumors using any medical diagnostic tool can be challenging due to the varying nature of this pathology. Magnetic Reso- nance Imaging (MRI) is an established diagnostic tool for various diseases and disorders and plays a major role in clinical neuro-diagnosis. Supplementing this technique with automated classification and segmentation tools is gaining importance, to reduce errors and time needed to make a conclusive diagnosis. In this paper a simple three-step algorithm is proposed; (1) identification of patients that present with tumors, (2) automatic selection of abnormal slices of the patients, and (3) segmentation and detection of the tumor. Features were extracted by using discrete wavelet transform on the normalized images and classified by support vector machine (for step (1)) and random forest (for step (2)). The 400 subjects were divided in a 3:1 ratio between training and test with no overlap. This study is novel in terms of use of data, as it employed the entire T2 weighted slices as a single image for classification and a unique combination of contralateral approach with patch thresholding for segmentation, which does not require a training set or a template as is used by most segmentation studies. Using the proposed method, the tumors were segmented accurately with a classification accuracy of 95% with 100% specificity and 90% sensitivity.
Mountkeithite, a new pyroaurite-related mineral with an expanded interlayer containing exchangeable MgSO4

Abstract Mountkeithite [(Mg,Ni)9(Fe3+,Cr,Al)3(OH)24]3+[(CO{in3,SO4)1.5(Mg,Ni)2(SO4)2(H2O)11]3− occurs with pyrite, magnetite, magnesite, hexahydrite, and morenosite in a low-temperature hydrothermal vein system in the Mount Keith disseminated nickel sulphide deposit, Western Australia. Electron-microprobe analyses gave the following average composition: MgO 31.7, NiO 6.1, CuO 0.1, Cr2O3 6.1, Fe2O3 8.3, Al2O3 2.6, SO3 14.7; microanalysis for C and H gave CO2 3.9, H2O 30.6; total 104.1. The X-ray powder diffraction pattern has the following strongest lines: 11.30(10), 5.63(8), 4.63(2), 3.765(6), 2.645(4), 2.545(4), 1.554(5), and 1.505(3); these can be indexed on a hexagonal cell with a = 10.698 Å, c = 22.545 Å. Mountkeithite occurs as friable aggregates and rosettes composed of soft, pearly to translucent, pale pink to white flakes with perfect basal cleavage. Optical properties are uniaxial negative with ɛ = 1.51 and ω = 1.52; weakly dichroic from colourless to palest pink. Specific gravity is 2.12 (calc. 1.95). Mountkeithite is soluble, with efferves-cence, in dilute HCl. Mountkeithite changes to a pyroaurite-like phase, with a 7.8. Å basal spacing when immersed in water, but can be changed back to an 11.3 Å phase by immersion in 1M MgSO4; mountkeithite also collapses to a 7.8 Å basal spacing under vacuum. Phases similar to mountkeithite have been synthesized by immersing grains of stichtite in 1M MgSO4, at 20, 50, 105, and 200°C. The structure of mountkeithite is interpreted as consisting of positively charged brucite-like hydroxyl layers, containing both divalent and trivalent cations, separated by about 7 Å-thick, negatively charged interlayers containing carbonate and sulphate anions, magnesium sulphate, and water. Carrboydite, motukoreaite, and hydrohonessite are minerals with similarly large basal spacings of 10–11 Å, and are also believed to have pyroaurite-related structures with expanded interlayers.
Reverse-Phase Phosphoproteome Analysis of Signaling Pathways Induced by Rift Valley Fever Virus in Human Small Airway Epithelial Cells

Rift valley fever virus (RVFV) infection is an emerging zoonotic disease endemic in many countries of sub-Saharan Africa and in Egypt. In this study we show that human small airway epithelial cells are highly susceptible to RVFV virulent strain ZH-501 and the attenuated strain MP-12. We used the reverse-phase protein arrays technology to identify phosphoprotein signaling pathways modulated during infection of cultured airway epithelium. ZH-501 infection induced activation of MAP kinases (p38, JNK and ERK) and downstream transcriptional factors [STAT1 (Y701), ATF2 (T69/71), MSK1 (S360) and CREB (S133)]. NF-κB phosphorylation was also increased. Activation of p53 (S15, S46) correlated with the increased levels of cleaved effector caspase-3, -6 and -7, indicating activation of the extrinsic apoptotic pathway. RVFV infection downregulated phosphorylation of a major anti-apoptotic regulator of survival pathways, AKT (S473), along with phosphorylation of FOX 01/03 (T24/31) which controls cell cycle arrest downstream from AKT. Consistent with this, the level of apoptosis inhibitor XIAP was decreased. However, the intrinsic apoptotic pathway marker, caspase-9, demonstrated only a marginal activation accompanied by an increased level of the inhibitor of apoptosome formation, HSP27. Concentration of the autophagy marker, LC3B, which often accompanies the pro-survival signaling, was decreased. Cumulatively, our analysis of RVFV infection in lung epithelium indicated a viral strategy directed toward the control of cell apoptosis through a number of transcriptional factors. Analyses of MP-12 titers in challenged cells in the presence of MAPK inhibitors indicated that activation of p38 represents a protective cell response while ERK activation controls viral replication.
Managing Classroom Behavior.

Throughout this book, we have discussed various Direct Instruction programs that are effective in teaching students academic skills. At this point it should be obvious that a lack of academic progress should not be viewed as a student problem but as an instructional one. Student behavior is similar in that misbehavior is frequently viewed as a “student problem. ” However, behavior management problems are often an indication of weaknesses in the instructional and management procedures used in the classroom. For instance, we know from the effective teaching research literature what excellent teacher performance is. Excellent teacher performance results from appropriate curricular pacing, lesson pacing, and transition management (Hofmeister & Lubke, 1990). As shown in Figure 1, these teacher behaviors contribute to instructional momentum.
Bayesian optimization for parameter tuning in evolutionary algorithms

Advances in evolutionary computation have demonstrated that Evolutionary Algorithms (EAs) proposed in this area are a solid alternative for solving combinatorial and continuous optimization problems. Despite their success in innumerable real-world scenarios, EAs depend on a set of input parameters that characterize their performance and need to be adjusted. In fact, identifying and setting the most appropriate parameters for an EA is a complex task, which, in some cases, can be as difficult as the optimization problem at hand. Recently, parameter tuning has attracted the interest of the research community, designing and proposing techniques that (1) help the algorithm to perform to its best, and (2), indirectly, make fairer comparisons of different methods. In this manuscript, we propose a novel offline parameter tuning algorithm based on Bayesian Optimization, a sequential design strategy for global optimization. In order to illustrate the validity of the proposed method, we considered as a case of study the Hybrid Kernel EDA, an EA that is characterized by 6 parameters. We ran the algorithm with the parameters tuned by means of Bayesian Optimization, and compared the results with those obtained by setting the parameters by hand (using some prior knowledge). Experiments were carried out on a benchmark of 60 instances of the permutation flowshop scheduling problem. Experimental results show that, in general, Hybrid Kernel EDA obtains better results when using the parameters tuned by means of Bayesian Optimization.
When Quality Is in the Eye of the Beholder: Paradigm Communities and the Certification of Standards for Judging Quality

This essay addresses the relativity of knowledge and its relevance to the assessment of quality in translation. The discussion is framed in terms of Thomas Kuhn’s theory of paradigms and paradigm communities. The concept of paradigm is used to delineate the various legacies that inform contemporary translators—their biblical/theological education, their tacit acceptance of an Aristotelian philosophy of language, and the subtle influence of the Age of Enlightenment. Because each model of translation determines the praxis of translation, it also determines how quality is assessed. It is suggested that this is not a serious problem, however, because each model of translation accounts well for particular phenomena of language. A translator is well advised to know the kinds of phenomena that each model handles best. Skill in translation is applying each model to the appropriate phenomena and thereby utilizing any given model to its maximum potential. The burden of responsibility for the quality of a translation falls correctly upon translators and not upon those who check translations.
Stackelberg Game Approach of H 2 / H ∞ Control for Weakly Coupled Stochastic Systems *

Abstract— In this paper, H2/H∞ control problem for linear weakly coupled stochastic system with state and external disturbance dependent noise involving multiple decision makers is investigated. After defining strategy set that is based on Stackelberg game, the existence conditions of the proposed strategy set that consists of cross-coupled algebraic nonlinear matrix equations (CANMEs) with small parameter are established. The asymptotic structure of CANMEs is shown for the first time. Particularly, the leader’s strategy set are chosen as Pareto strategy set. In order to obtain a solution set, a numerical algorithm is discussed. A simple numerical example is given to demonstrate the efficiency of the proposed method.
Expression pattern of the maternal factor zygote arrest 1 (Zar1) in bovine tissues, oocytes, and embryos

Zygote arrest 1 (Zar1) is an ovary‐specific maternal factor that plays an essential role during the oocyte‐to‐embryo transition in mouse. In this species, Zar1 expression is strictly limited to the oocyte, the zygote and, at a lower level, the 2‐cell embryo. Aim of the present study was to analyze the presence and the expression pattern of the Zar1 ortholog in bovine tissues and embryos. Reverse transcription (RT)‐polymerase chain reaction (PCR) analysis was performed in a panel of bovine tissues, in oocytes and pre‐implantation in vitro produced embryos. The results demonstrated that a Zar1 ortholog is present in cattle. In the adult, the gene is expressed in ovary, testis, muscle, and myocardium. The gene is also expressed in the oocyte, the zygote, and in all the stages of embryonic development until blastocyst formation. A semi‐quantitative RT‐PCR analysis revealed that Zar1 levels are constant through in vitro development with the exception of the 4‐cell stage, when a significant increase is observed. The exposure of fertilized oocytes to the RNA polymerase II inhibitor alpha‐amanitin was able to suppress this Zar1 increase indicating that transcription of this gene occurs at the 4‐cell stage. Zar1 is conserved in cattle but has an expression pattern different from the mouse. In particular, Zar1 expression in the adult is not limited to the ovary and in the embryo is expressed well beyond the oocyte to embryo transition. Moreover, the identification of Zar1 transcription at the 4‐cell stage represents the first characterization of one of the genes expressed in cattle embryos before the major onset of embryonic transcription. Mol. Reprod. Dev. 69: 375–380, 2004. © 2004 Wiley‐Liss, Inc.
The History and Concept of Mathematical Proof

A mathematician is a master of critical thinking, of analysis, and of deductive reasoning. These skills travel well, and can be applied in a large variety of situations—and in many different disciplines. Today, mathematical skills are being put to good use in medicine, physics, law, commerce, Internet design, engineering, chemistry, biological science, social science, anthropology, genetics, warfare, cryptography, plastic surgery, security analysis, data manipulation, computer science, and in many other disciplines and endeavors as well. The unique feature that sets mathematics apart from other sciences, from philosophy, and indeed from all other forms of intellectual discourse, is the use of rigorous proof. It is the proof concept that makes the subject cohere, that gives it its timelessness, and that enables it to travel well. The purpose of this discussion is to describe proof, to put it in context, to give its history, and to explain its significance. There is no other scientific or analytical discipline that uses proof as readily and routinely as does mathematics. This is the device that makes theoretical mathematics special: the tightly knit chain of reasoning, following strict logical rules, that leads inexorably to a particular conclusion. It is proof that is our device for establishing the absolute and irrevocable truth of statements in our subject. This is the reason that we can depend on mathematics that was done by Euclid 2300 years ago as readily as we believe in the mathematics that is done today. No other discipline can make such an assertion.
Absence in Bacillus subtilis and Staphylococcus aureus of the sequence-specific deoxyribonucleic acid methylation that is conferred in Escherichia coli K-12 by the dam and dcm enzymes

Restriction analysis of plasmid pHV14 deoxyribonucleic acid isolated from Escherichia coli K-12, Bacillus subtilis, and staphylococcus aureus with restriction endonucleases MboI, Sau3AI, and EcoRII was used to study the methylation of those nucleotide sequences which in E. coli contain the major portions of N6-methyladenine and 5-methylcytosine. The results showed that neither B. subtilis nor S. aureus methylates deoxyribonucleic acid at the same sites and nucleotides which are recognized and methylated by dam and dcm enzymes in E. coli K-12.
The Process and Meaning of Sexual Assault Disclosure

Disclosure of sexual assault is a complicated process which depends upon a host of factors, such as assault characteristics, the victim’s interpretation, and the level of distress she experiences. Comprehensive theories of adult sexual assault disclosure have not been proposed. Most studies concentrate on a particular aspect of disclosure, such as outcomes of disclosure and reasons for disclosing versus not disclosing. A number of gaps exist in the current literature on adult sexual assault disclosure. These include the conceptualization of disclosure as a discrete or continuous variable; how it may evolve during stages of recovery; the progression of disclosure (e.g., observable patterns to disclosing); the potential variety of motivations for disclosing beyond help-seeking; and the role of culture (e.g., how one’s cultural and familial upbringing influences comfort and acceptance of disclosure as a viable option). The present study aimed to clarify and expand our previous knowledge about disclosure of sexual assault by investigating the overall process. A qualitative study, using a grounded theory approach, was conducted with a diverse sample of women who were sexually victimized after age 12. Findings from the study reveal the complex nature of disclosure and expand on previous conceptions of its process and behavioral manifestations, such as evidence supporting a disclosure continuum, a variety of motivations for disclosing and not disclosing, the roles of culture and parenting practices that may influence disclosure, and the interactive nature of disclosure and recovery. The results suggest that the disclosure process consists of the factors that contribute to whether a disclosure is made, the disclosure itself, and the aftereffects of the disclosure, a process which could be conceived as occurring in circular manner. Thus, decisions of disclosure appear to be very complex, and all of these factors potentially interact with one another and collectively influence whether a woman discloses and how much. A number of research and practical implications are discussed including examining the relationship between motivations and current recovery stages, modifying our conceptualization of disclosure (as continuous rather than dichotomous), and recognizing the needs and concerns of diverse cultural groups in their decisions to disclose. INDEX WORDS: Disclosure, Sexual Assault, Rape, Culture, Recovery, Grounded Theory, Qualitative, Measurement THE PROCESS AND MEANING OF SEXUAL ASSAULT DISCLOSURE SENSE OF
Relation between Obesity and Bone Mineral Density and Vertebral Fractures in Korean Postmenopausal Women

Purpose The traditional belief that obesity is protective against osteoporosis has been questioned. Recent epidemiologic studies show that body fat itself may be a risk factor for osteoporosis and bone fractures. Accumulating evidence suggests that metabolic syndrome and the individual components of metabolic syndrome such as hypertension, increased triglycerides, and reduced high-density lipoprotein cholesterol are also risk factors for low bone mineral density. Using a cross sectional study design, we evaluated the associations between obesity or metabolic syndrome and bone mineral density (BMD) or vertebral fracture. Materials and Methods A total of 907 postmenopausal healthy female subjects, aged 60-79 years, were recruited from woman hospitals in Seoul, South Korea. BMD, vetebral fracture, bone markers, and body composition including body weight, body mass index (BMI), percentage body fat, and waist circumference were measured. Results After adjusting for age, smoking status, alcohol consumption, total calcium intake, and total energy intake, waist circumference was negatively related to BMD of all sites (lumbar BMD p = 0.037, all sites of femur BMD p < 0.001) whereas body weight was still positively related to BMD of all sites (p < 0.001). Percentage body fat and waist circumference were much higher in the fracture group than the non-fracture group (p = 0.0383, 0.082 respectively). Serum glucose levels were postively correlated to lumbar BMD (p = 0.016), femoral neck BMD (p = 0.0335), and femoral trochanter BMD (p = 0.0082). Serum high density lipoprotein cholesterol (HDLC) was positively related to femoral trochanter BMD (p = 0.0366) and was lower in the control group than the fracture group (p = 0.011). Conclusion In contrast to the effect favorable body weight on bone mineral density, high percentage body fat and waist circumference are related to low BMD and a vertebral fracture. Some components of metabolic syndrome were related to BMD and a vertebral fracture.
Nuclear Structures Surrounding Internal Lamin Invaginations

A‐ and C‐type lamins are intermediate filament proteins responsible for the maintenance of nuclear shape and most likely nuclear architecture. Here, we propose that pronounced invaginations of A/C‐type lamins into the nuclear interior represent channels for the transport of regulatory molecules to and from nuclear and nucleolar regions. Using fluorescent protein technology and immunofluorescence, we show that A‐type lamin channels interact with several nuclear components, including fibrillarin‐ and UBF‐positive regions of nucleoli, foci of heterochromatin protein 1 β, polycomb group bodies, and genomic regions associated with DNA repair. Similar associations were observed between A/C‐type lamin channels and nuclear pores, lamin‐associated protein LAP2α, and promyelocytic leukemia nuclear bodies. Interestingly, regions with high levels of A/C‐type lamins had low levels of B‐type lamins, and vice versa. These characteristics were observed in primary and immortalized mouse embryonic fibroblasts as well as human and mouse embryonic stem cell colonies exhibiting stem cell‐specific lamin positivity. Our findings indicate that internal channels formed by nuclear lamins likely contribute to normal cellular processes through association with various nuclear and nucleolar structures. J. Cell. Biochem. 115: 476–487, 2014. © 2013 Wiley Periodicals, Inc.
Multifunctional solid/solid phononic crystal

A two-dimensional, solid/solid phononic crystal (PC) comprised a square array of steel cylinders in epoxy is shown to perform a variety of spectral, wave vector, and phase-space functions. Over a range of operating frequencies, the PC’s elastic band structure shows uniquely shaped equifrequency contours that are only accessible to excitations of longitudinal polarization. Under this condition, the PC is shown to behave as (1) an acoustic wave collimator, (2) a defect-less wave guide, (3) a directional source for elastic waves, (4) an acoustic beam splitter, (5) a phase-control device, and (6) a k-space multiplexer. Wave vector diagrams and finite-difference time-domain simulations are employed to authenticate the above mentioned capabilities.
CUBA: an architecture for efficient CPU/co-processor data communication

Data-parallel co-processors have the potential to improve performance in highly parallel regions of code when coupled to a general-purpose CPU. However, applications often have to be modified in non-intuitive and complicated ways to mitigate the cost of data marshalling between the CPU and the co-processor. In some applications the overheads cannot be amortized and co-processors are unable to provide benefit. The additional effort and complexity of incorporating co-processors makes it difficult, if not impossible, to effectively utilize co-processors in large applications. This paper presents CUBA, an architecture model where co-processors encapsulated as function calls can efficiently access their input and output data structures through pointer parameters. The key idea is to map the data structures required by the co-processor to the co-processor local memory as opposed to the CPU's main memory. The mapping in CUBA preserves the original layout of the shared data structures hosted in the co-processor local memory. The mapping renders the data marshalling process unnecessary and reduces the need for code changes in order to use the co-processors. CUBA allows the CPU to cache hosted data structures with a selective write-through cache policy, allowing the CPU to access hosted data structures while supporting efficient communication with the co-processors. Benchmark simulation results show that a CUBA-based system can approach optimal transfer rates while requiring few changes to the code that executes on the CPU.
Regional Disparities in China's Manufacturing Industry from 1987 to 2003

China's regional disparities are greatly discussed by academe, but there is limited attention on disparities in manufacturing industry, which plays a key role in the national economy. This paper uses the Gini Coefficient, Theil entropy index and the decomposition of Theil entropy index, to investigate regional disparities in manufacturing industry among provinces, between northern and southern China, among eastern, central and western China. The results indicate that, the disparity trend among provinces has been slowly increasing; the disparities among the eastern, central and western regions waved during the last few years, and the major source is the disparities between the three parts, the disparities within each region are small and decreasing; disparities are increasing for the North and the South, and the major source comes from the disparities within the South.