Miracle-dz/UniFAR-FTUs huggingface dataset:
Cytogenetic and AZF microdeletions on the Y chromosome of infertile men

Intervals V and VI of Yq11.23 regions contain responsible genes for spermatogenesis, and are named as “azoospermia factor locus” (AZF). Deletions of these genes are thought to be pathogenetically involved in some cases of male infertility associated with azoospermia or oligozoospermia. The aim of this study was to develop a method for the detection of the AZF region of the human Y chromosome in the Unit of Medical Genetics and Oncogenetics UGMO at the Hospital University Center Hassan II-FEZ. We applied multiplex polymerase chain reaction (PCR) using several sequence-tagged site (STS) primer sets, in order to determine microdeletions in the Y chromosome. Our findings suggest that the technique is validated, so genetic screening should be advised to infertile men before starting assisted reproductive treatments.
A new hybrid method to forecast wind turbine output power in power systems

Wind turbine power forecasting is one of the most challenging and tedious issues in the power engineering field. In this way, we suggest a probabilistic method based on a sufficient optimization tool to construct optimal prediction intervals PIs. Here we use combined lower upper bound method to capture the uncertainty of forecasting. In order to find the optimal PIs, a suitable multi-objective approach is employed to satisfy both PI coverage probability and PI width equally. According to the high complexity and nonlinearity of the problem, a new optimization algorithm called modified firefly algorithm MFA is employed to find the optimal PIs. The proposed modification method makes use of levy flight operator and crossover operations to increase the diversity of the fireflies in the population. In order to see the satisfying performance of the proposed method, the practical dataset of the Wind Farm located near Cape Jervis on the Fleurieu Peninsula in Australia is used as the case study.
A Game Theoretical Approach for Solving Winner Determination Problems

Determining the winners in combinatorial auctions to maximize the auctioneer's revenue is an NP-complete problem. Computing an optimal solution requires huge computation time in some instances. In this paper, we apply three concepts of the game theory to design an approximation algorithm: the stability of the Nash equilibrium, the self-learning of the evolutionary game, and the mistake making of the trembling hand assumption. According to our simulation results, the proposed algorithm produces near-optimal solutions in terms of the auctioneer's revenue. Moreover, reasonable computation time is another advantage of applying the proposed algorithm to the real-world services.
Firm Behaviour Under Uncertainty: A Simple Parametric Model

In this paper, we model production technology in a state‐contingent framework. We assume that all the firms use the same stochastic technology, but they may have different risk attitudes and information sets, and ex post they may operate in different production environments. Firms maximise ex ante their preference function subject to a stochastic technology constraint; in other words, they are assumed to act rationally, thereby leaving no room for either technical or allocative inefficiency. We provide a simple parametric functional form to represent the state‐contingent technology. Using simple numerical examples, we illustrate how optimal input–output choices are dramatically affected when firms have different preferences and information sets. Thus, we show that the observed disparateness of production choices among different firms can actually be attributed to the stochastic nature of the decision environment.
Modelos de madurez de Green IT: un mapeo sistemático

El auge de las Tecnologias de la Informacion ha impactado no solo en la forma de hacer negocios y en la transformacion digital de las organizaciones, sino tambien en la sostenibilidad, adquiriendo una especial relevancia a traves de la idea del Green IT. El Green IT se esta convirtiendo en un area indispensable en las organizaciones y en una demanda social. Sin embargo, las organizaciones no cuentan con los mecanismos necesarios para evaluar su madurez y mejorar en este ambito. Por ello, el objetivo del presente estudio es llevar a cabo un mapeo sistematico para recopilar el estado del arte de los modelos de madurez de sostenibilidad y, en especial, de Green IT, con el fin de establecer una guia para poder desarrollar un modelo de madurez de Green IT. Los resultados obtenidos demuestran la novedad del area y la falta de un modelo de madurez de Green IT solido y, por ello, la necesidad de elaborar y validar un modelo de este tipo.
Enhanced Pressor Response to Increased CSF Sodium Concentration and to Central Angiotensin I in Heterozygous α 2 Na , K-ATPase Knockout Mice *

Intracerebroventricular (i.c.v.) infusion of NaCl mimics the effects of a high-salt diet in salt-sensitive hypertension, raising the sodium concentration in the cerebrospinal fluid (CSF [Na]) and subsequently increasing the concentration of an endogenous ouabain-like substance (OLS) in the brain. The OLS in turn inhibits the brain Na, K-ATPase, causing an increase in the activity of the brain renin-angiotensin system (RAS) and blood pressure. The Na, K-ATPase α (catalytic) isoform(s) that mediate the pressor response to increased CSF [Na] is (are) unknown, but it is likely that one or more isoforms that bind ouabain with high affinity are involved (e.g., the Na, K-ATPase α2 and/or α3 subunits). We hypothesize that OLS-induced inhibition of the α2 subunit mediates this response. Therefore, a chronic reduction in α2 expression via a heterozygous gene knockout (α2 +/-) should enhance the pressor response to increased CSF [Na]. Intracerebroventricular (i.c.v.) infusion of artificial CSF containing 0.225 M NaCl increased mean arterial pressure (MAP) in both wild-type (+/+) and α2 +/mice, but to a greater extent in α2 +/-. Likewise, the pressor response to i.c. v. ouabain was enhanced in α2 +/mice, demonstrating enhanced sensitivity to brain Na, K-ATPase inhibition per se. The pressor response to i.c. v. angiotensin I but not ANG II was also enhanced in α2 +/vs. +/+ mice, suggesting an enhanced brain RAS activity that may be mediated by increased brain angiotensin converting enzyme (ACE). The latter hypothesis is supported by enhanced ACE ligand binding in the organum vasculosum laminae terminalis (OVLT). These studies demonstrate that chronic downregulation of Na, K-ATPase α2 isoform expression by heterozygous knockout increases the pressor response to increased CSF [Na] and activates the brain RAS. Since these changes mimic those produced by the endogenous brain OLS, the brain α2 isoform may be a target for the brain OLS during increases in CSF [Na], such as in salt-dependent hypertension.
UM BREVE OLHAR SOBRE A CIENCIOMETRIA: ORIGEM, EVOLUÇÃO, TENDÊNCIAS E SUA CONTRIBUIÇÃO PARA O ENSINO DE CIÊNCIAS

O presente trabalho faz uma análise contextualizada a partir de um estudo bibliográfico sobre a Cienciometria, a qual se caracteriza como um novo ramo da ciência definida como o estudo da mensuração e quantificação do progresso científico, onde a pesquisa baseia-se em indicadores bibliométricos. Nesse cenário o presente trabalho tem como intuito percorrer a história, desvelando a possível origem da Cienciometria, seu desenvolvimento no mundo, no Brasil e ao final indicar possíveis tendências. A metodologia de execução deste trabalho caracteriza-se por um estudo de revisão bibliográfica sobre a referida temática, visando localizá-la e diferenciá-la na Ciência da Informação junto com os demais ramos da ciência de mensuração como a Bibliometria, a Informetria e a Webometria. As análises e discussões proporcionaram a verificação da necessidade do surgimento da Cienciometria dentro do cenário mundial, bem como a sua importância para com a avaliação da produção científica, fornecendo indicadores e subsídios para a comunidade acadêmica e sociedade em geral, pois, além de apontar possíveis problemáticas relacionadas ao modelo quantitativo, indica as soluções para se observar a realidade social do pesquisador ou da pesquisa e também contribuir para a visualização de lacunas e de temáticas que são pouco investigadas.
Gender differences in substance use disorders.

OBJECTIVE The goals of this study were to explore gender differences in demographic variables, psychiatric comorbidity, and personality disorders in individuals with substance use disorders. METHOD A total of 100 treatment-seeking substance users (50 men and 50 women) admitted to a university-based and a university-affiliated private chemical dependency hospital were compared with regard to demographic variables and comorbid psychiatric and personality diagnosis according to the Structured Clinical Interview for DSM-III-R after 14-21 days in treatment. RESULTS Men were significantly more likely to have a higher household income and to be alcohol dependent. Women were significantly more likely to have another axis I disorder in addition to substance use disorder, particularly anxiety disorders, but these gender differences were not substantially different from the gender prevalence of these disorders in the general population. Men had more affective disorders relative to women than would be expected from the general population data. Female alcoholics had substantially more psychopathology than male alcoholics, and generally these differences were consistent with the ratios of these disorders in the general population. For cocaine users, female/male ratios of anxiety and affective disorders were inconsistent with general population ratios and indicated more psychopathology than would be expected in male cocaine users. There were no gender differences in axis II diagnoses. CONCLUSIONS Some of the gender differences in psychopathology in substance users are at odds with gender differences for psychopathology in the general population. Further exploration of these differences could have important theoretical and treatment implications.
Analysis of Influencing Factors of Heat Transfer Performance of Heat Pipe Heat Exchanger

Heat transfer performance of heat pipe heat exchanger affected by many factors, such as the opening temperature of the heat pipe , the rate of fluid-filled, the physical nature of liquid refrigerant ¿the work temperature of tube , angle, tube spacing, tube length, hot and cold fluid flow and wind speed. The above -mentioned parameters can not be measured because of Test conditions, therefore, this article explores influencing factors of heat transfer performance of Heat pipe heat exchanger using VB: such as tube length, diameter, tube spacing, fin parameters changes in the heat pipe heat exchanger performance.
ANTIGENIC, PHENOTYPIC AND MOLECULAR CHARACTERIZATION CONFIRMS BABESIA ODOCOILEI ISOLATED FROM THREE CERVIDS

Babesia isolates from an elk (Cervus elaphus canadensis) and a caribou (Rangifer tarandus caribou) with fatal infections were compared to Babesia odocoilei (Engeling isolate) from white-tailed deer (Odocoileus virginianus) by experimental infection, serologic, and small subunit ribosomal RNA (SSU rRNA) gene sequence analysis studies. Both the indirect fluorescent antibody test and immunoprecipitation assays demonstrated antigenic variation among the isolates. Experimental infection studies showed no clinical differences among the isolates. Nucleotide sequence analysis showed that the elk and caribou Babesia sp. isolates possessed SSU rRNA genes with identical sequences to that of B. odocoilei. A phylogenetic tree constructed from SSU rRNA gene sequences shows that B. odocoilei is most closely related to Babesia divergens, both of which branch together in the true babesia clade.
Long-term effects of iron and zinc supplementation during infancy on cognitive function at 9 y of age in northeast Thai children: a follow-up study.

BACKGROUND Iron and zinc are important micronutrients for child growth and development. One would expect that iron and zinc supplementation in infancy would affect long-term cognitive development and school achievement, but this has not been evaluated. OBJECTIVE We investigated the effect of iron or zinc supplementation or both during infancy on cognitive performance 8 y later. DESIGN A follow-up study was performed in 560 children aged 9 y or 92% of those who had participated in a randomized controlled trial involving 4 groups who received daily iron, zinc, iron plus zinc, or a placebo at 4-6 mo of age for 6 mo. Cognitive performance was assessed by using the Wechsler Intelligence Scale for Children-Third Edition (Thai version), the Raven's Colored Progressive Matrices (CPM), and school performance tests. General linear mixed models were used to assess long-term effects. RESULTS No significant differences in any of the outcomes at 9 y of age were observed at follow-up between the 4 groups. Mean intelligence quotients ranged across groups from 92.9 to 93.7 for full scale, 93.9-95.4 for verbal, and 93.1-94.0 for performance. The Raven's CPM score ranged from 21.4 to 22.4. CONCLUSION Supplementation with iron or zinc or both during infancy does not lead to long-term cognitive improvement in 9-y-old children. This trial was registered at clinicaltrials.gov as NCT00824304.
Web-Weka1.0: Online Tool for Comparison of Classification Algorithms of Weka

Machine learning and Data mining are becoming increasingly important in the recent years and have been successfully applied to solve a number of problems, especially in the areas of science and engineering. A variety of algorithms exist in the popular data mining tool 'Weka' to classify a given set of records into different classes. However, choosing the right classifier among them is a tricky task as the performance of a particular algorithm depends on various factors such as the application domain and the data set. In order to aid the researchers in comparing the performances of various classification algorithms in Weka, we have developed an online resource named Web-Weka using which one can compare a set of classification algorithms on a single data set on the fly and choose the right classifier for their study. The tool is available for free at www.mcr. org.in/webweka.
A dimeric layered structure of a 4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine compound.

The title compound, 6-methylsulfanyl-1-(3-phenylpropyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one, C(15)H(16)N(4)OS, crystallizes in space group Pbca, with two molecules of similar structure in the asymmetric unit. The molecular structure shows the absence of intramolecular stacking in the crystalline state, as indicated by earlier (1)H NMR analysis in solution. In addition, the crystal packing reveals the formation of a layered structure, due mainly to intermolecular N[bond]H.O[double bond]C hydrogen bonding and arene-arene interactions.
Establishment of a Mucin‐Degrading Intestinal Microflora During the First Two Years of Human Life

The establishment of a mucin-degrading intestinal microflora was followed in 30 healthy Swedish children by agar gel electrophoresis of fecal samples taken at 0, 1, 3, 6, 9, 12, 15, 18, 21, and 24 months of age. At 3 months, 18 children showed a limited degree of mucin degradation, while 12 children showed no degradation. In children exclusively breast-fed for at least 4 months, mucin degradation was initiated significantly later than in children who received formula, with or without breast milk, by 1 month of age. Complete degradation of mucin was seen in 21 children after 1 year of age and in all children at 2 years. A positive correlation between increasing age and increased degradation of mucin was found between birth and 1 month and between 6 and 9 months, after standardization for the period of exposure to foods other than breast milk.
Effect of quercetin on performance and egg quality during the late laying period of hens

1. At the end of the peak laying period for fowl, both performance and egg quality decrease markedly. Counteracting either or both of these could, therefore, have significant positive economic implications. Quercetin, a typical representative of the flavonol compounds, has a variety of biological functions. However, there are no reported findings on its use as a feed additive. 2. In this study, we investigated the effects of quercetin on laying rate, egg quality and blood traits associated with egg quality in laying hens (Hessain) during the late laying period and explored the possibility of using quercetin as a functional feed additive. 3. The laying hens (n = 240; 39 weeks old) were randomly assigned to 4 treatments consisting of 6 replicates (n = 10) and were fed with diets containing quercetin at 0, 0.2, 0.4 or 0.6 g/kg. 4. Results showed that laying rate was increased and feed–egg ratio was decreased significantly by 0.2 and 0.4 g/kg quercetin. Compared with controls, Haugh unit, eggshell strength, eggshell thickness and yolk protein were increased, but yolk cholesterol was decreased by quercetin. 5. In conclusion, quercetin was beneficial in improving performance and egg quality. The recommended concentration of quercetin is 0.4 g/kg of the basal diet. At this concentration, increased laying rate, improved egg quality and reduced yolk cholesterol can be expected.
Delay-doppler ambiguity function of ultrawideband-throb signals

The performance of ultrawideband (UWB) radar in target detection, resolution, and recognition depends on the structure of the radar waveform. In this paper, the principles of waveform diversity and design (WDD) for generating periodic and orthogonal UWB-impulse signals are described. A mathematical model for a UWB-throb signal that yields the practical advantages of the widely used linear frequency-modulation (FM) ldquochirprdquo signal is presented. The structure of the UWB-throb signal is designed based on a pulse-time modulation scheme. The delay-Doppler ambiguity function of the UWB-throb signal is derived for performance analysis. Computer plots of the UWB-throb signal, its autocorrelation function, and ambiguity function are generated to illustrate its characteristics and advantages for high-resolution impulse radar.
Application of stem cells in targeted therapy of breast cancer: a systematic review.

BACKGROUND The aim of this systematic review was to investigate whether stem cells could be effectively applied in targeted therapy of breast cancer. MATERIAL AND METHOD A systematic literature search was performed for original articles published from January 2007 until May 2012. RESULTS Nine studies met the inclusion criteria for phase I or II clinical trials, of which three used stem cells as vehicles, two trials used autologous hematopoetic stem cells and in four trials cancer stem cells were targeted. Mesenchymal stem cells (MSCs) were applied as cellular vehicles to transfer therapeutic agents. Cell therapy with MSC can successfully target resistant cancers. Cancer stem cells were selectively targeted via a proteasome-dependent suicide gene leading to tumor regression. Wnt/β-catenin signaling pathway has been also evidenced to be an attractive CSC-target. CONCLUSIONS This systematic review focused on two different concepts of stem cells and breast cancer marking a turning point in the trials that applied stem cells as cellular vehicles for targeted delivery therapy as well as CSC-targeted therapies. Applying stem cells as targeted therapy could be an effective therapeutic approach for treatment of breast cancer in the clinic and in therapeutic marketing; however this needs to be confirmed with further clinical investigations.
Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis

The biosynthesis of immunoglobulin leads to constitutive endoplasmic reticulum (ER) stress in myeloma cells, which activates the unfolded protein response (UPR). The UPR promotes protein folding by chaperones and increases proteasomal degradation of misfolded protein. Excessive ER stress induces apoptosis and represents a molecular basis for the bortezomib sensitivity of myeloma. Most solid malignancies such as sarcoma, by contrast, are poorly bortezomib sensitive and display low levels of ER stress. We hypothesized that pharmacologic induction of ER stress might sensitize malignancies to bortezomib treatment. We show that the HIV protease inhibitor ritonavir induces ER stress in bortezomib-resistant sarcoma cells. Ritonavir triggered the UPR, decreased the degradation of newly synthesized protein, but did not directly inhibit proteasomal active sites in the therapeutic dose range in contrast to bortezomib. Whereas neither bortezomib nor ritonavir monotherapy translated into significant apoptosis at therapeutic drug levels, the combination strongly increased the level of ER stress and activated PERK, IRE1, and ATF6, synergistically induced CHOP, JNK, caspase-4, and caspase-9, and resulted in >90% apoptosis. In summary, ritonavir increases the level of ER stress induced by bortezomib, which sensitizes bortezomib-resistant cells to bortezomib-induced apoptosis. Ritonavir may therefore be tested clinically to improve the sensitivity of solid malignancies toward bortezomib treatment. [Mol Cancer Ther 2008;7(7):1940–8]
Huntington Disease in a 9-Year-Old Boy: Clinical Course and Neuropathologic Examination

Huntington disease is a dominantly inherited, neurodegenerative disorder, usually with onset in the fourth to fifth decade of life but in a small proportion of patients before the age of 20 years. The early-onset form, juvenile Huntington disease, is clinically different from that of more common adult-onset forms and includes cognitive decline, parkinsonism, myoclonus, and seizures. We report a case of a boy with juvenile Huntington disease with a very early age at disease onset (3 years). The suspected clinical diagnosis was confirmed by DNA analysis, which revealed (CAG)n expansion into the range characteristic of juvenile Huntington disease (95 repeats). The clinical course of the disease was typical for the juvenile form of Huntington disease, but the diagnosis was not so obvious because there was no history of any neurodegenerative disorder in the family. The child died at the age of 11 years. The detailed neuropathologic investigations performed postmortem showed the characteristic features of Huntington disease. As the patient's de novo mutation was very unlikely to occur, genetic counseling and the possibility of predictive testing were proposed to the family. Indirect molecular data indicate the familial character of the disease, with strong anticipation of transmission.