Miracle-dz/UniFAR-FTUs huggingface dataset:
Satisfaction with Life, Meaning in Life, Sad Childhood Experiences, and Psychological Symptoms among Turkish Students

The aim of the current study was to investigate the contributions of sad childhood experiences, depression, anxiety, and stress, existence of a sense of meaning, and pursuit of meaning in explaining life satisfaction of young adults in Turkey. The sample comprised 400 undergraduate students (M age = 20.2 yr.) selected via random cluster sampling. There were no statistically significant differences between men and women in terms of their scores on depression, existence of meaning, pursuit of meaning, and life satisfaction scores. However, there were statistically significant differences between men and women on the sad childhood experiences, anxiety and stress. In heirarchical regression analysis, the model as a whole was significant. Depression and existence of meaning in life made unique significant contributions to the variance in satisfaction in life. Students with lower depression and with a sense of meaning in life tended to be more satisfied with life.
Putting all their eggs in one basket? Portfolio diversification 1870–1902

ABSTRACT There are a number of reasons why investor portfolio characteristics are of interest. First, there is limited evidence of what individual investors actually held in their portfolios in the past, including, for example, whether there were significant differences between male and female investors. Second, investors’ portfolio holdings are relevant to the debate on the ‘democratisation’ of investment and, third, they inform the debate on whether investors in the past made efforts to reduce portfolio risk through diversification, before the full ‘scientific’ approach of the early-twentieth century and the Markowitz optimisation approach of the mid-twentieth century. This research explores the portfolio choices made by a sample of 508 investors – 263 men and 245 women – between 1870 and 1902. Evidence of diversification exists, with the average holding of the sample being 4.6 securities. There is also evidence of increasing levels of diversification over time, of international diversification, and greater diversification by wealthy men and women. Investors in the past clearly made efforts to reduce portfolio risk before Markowitz optimisation.
Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapy

A substantial proportion of hepatitis C virus (HCV)‐1b–infected patients still do not respond to interferon‐based therapy. This study aims to explore a predictive marker for the ultimate virological response of HCV‐1b–infected patients treated with pegylated interferon/ribavirin (PEG‐IFN/RBV) combination therapy. Nonstructural protein 5A (NS5A) sequences of HCV in the pretreated sera of 45 patients infected with HCV‐1b were analyzed. The mean number of mutations in the variable region 3 (V3) plus its upstream flanking region of NS5A (amino acid 2334–2379), referred to as IFN/RBV resistance‐determining region (IRRDR), was significantly higher for HCV isolates obtained from patients who later achieved sustained virological response (SVR) by PEG‐IFN/RBV than for those in patients undergoing non‐SVR. The receiver operating characteristic curve analysis estimated six mutations in IRRDR as the optimal threshold for SVR prediction. Indeed, 16 (76%) of 21 SVR, but only 2 (8%) of 24 non‐SVR, had HCV with six or more mutations in IRRDR (IRRDR ≥ 6) (P < 0.0001). All of 18 patients infected with HCV of IRRDR of 6 or greater examined showed a significant (≥1 log) reduction or disappearance of serum HCV core antigen titers within 24 hours after initial dose of PEG‐IFN/RBV, whereas 10 (37%) of 27 patients with HCV of IRRDR of 5 or less did (P < 0.0001). The positive predictive value of IRRDR of 6 or greater for SVR was 89% (16/18; P = 0.0007), with its negative predictive value for non‐SVR being 81% (22/27; P = 0.0008). Conclusion: A high degree (≥6) of sequence variation in IRRDR would be a useful marker for predicting SVR, whereas a less diverse (≤5) IRRDR sequence predicts non‐SVR. (HEPATOLOGY 2008.)
Research on improved focused crawler and its application in food safety public opinion analysis

In big data environment, the performance of the focused crawler has a great impact on the results of crawling. In order to improve the efficiency and accuracy of focused crawler, this paper proposed a combination method of HTML analysis and text density and multi-reference factors similarity calculation method based on the basic principle and key technologies of focused crawler. The proposed method calculated the similarity of web page by the page content and crawler theme. This method can significantly improve the accuracy of web text density of focused crawler. Meanwhile, the proposed method also optimized the initial seed module and dynamic threshold module to implement a new web focused crawler system for specific topics. Finally, this paper also used the improved crawler, Best-First crawler and Breadth-First crawler to collect the public opinion data of the big data with the topic of food safety and analyzed the performance and efficiency of the crawling results. The results show that the improved crawler can improve the feasibility and efficiency compared with the other two crawlers. Moreover, this paper proved that the focused crawler based on text density and multi-factor similarity calculate can be applied efficiently in food safety public opinion analysis.
Computational Model For Chromatographic Relative Retention Time of Polychlorinated Biphenyls Using Sub-structural Molecular Fragments

Quantitative structure-retention relationship (QSRR) analysis is a useful technique capable of relating chromato- graphic retention time to the chemical structure of a solute. Using the sub-structural molecular fragments (SMF) derived directly from the molecular structures, the gas chromatographic relative retention times (RRTs) of 209 polychlorinated biphenyls (PCBs) on the SE-54 stationary phase were calculated. An eight-variable regression equation with the correlation coefficient of 0.9945 and the root mean square errors of 0.0134 was developed. Forward and backward stepwise regression variable selection and multi-linear regression analysis (MLRA) are combined to describe the effect of molecular structure on the RRT of PCB according to the QSRR method. To quantitatively relate RRT with the molecular structure MLR analysis is performed on the set of 163 sub-structural molecular fragments (SMF) provided by the ISIDA software. The eight fragments selected by variable subset selection, all belonging to the sub-fragments, adequately represent the structural factors influencing the affinity of PCB to SE-54 stationary phase in the separation process. Finally, a QSRR model is selected based on leave-one-out cross-validation and its prediction ability is further tested on 42 representative compounds excluded from model calibration. The prediction results from the MLR model are in good agreement with the experimental values. By applying the MLR method we can predict the test set with squared cross validated correlation coefficient (Q 2) of 0.9913 and root mean square error (RMSE) of 0.0169.
Prevention of Chronic Rejection in Murine Cardiac Allografts: A Comparison of Chimerism- and Nonchimerism-Inducing Costimulation Blockade-Based Tolerance Induction Regimens1

We have previously described a nonirradiation-based regimen combining costimulation blockade, busulfan, and donor bone marrow cells that promotes stable, high level chimerism, deletion of donor-reactive T cells, and indefinite survival of skin allografts in mice. The purpose of the current study is to determine the efficacy of this tolerance regimen in preventing acute and chronic rejection in a vascularized heart graft model and to compare this regimen with other putative tolerance protocols. Mice receiving costimulation blockade (CTLA4-Ig and anti-CD40 ligand) alone or in combination with donor cells enjoyed markedly prolonged heart graft survival and initially preserved histological structure. However, tolerance was not achieved, as evidenced by the eventual onset of chronic rejection characterized by obliterative vasculopathy and the rejection of secondary skin grafts. In contrast, following treatment with costimulation blockade, busulfan, and bone marrow, heart grafts survived indefinitely without detectable signs of chronic rejection or structural damage, even 100 days after placement of a secondary donor skin graft. We detected multilineage chimerism in peripheral blood, spleen, lymph nodes, and thymus, and peripheral deletion of donor-reactive cells was complete by day 90. These findings indicate that only the CD40/CD28 blockade chimerism induction regimen prevents both acute and chronic rejection of vascularized organ transplants. Further testing of these strategies in a preclinical large animal model is warranted.
Imaging and permittivity variation record of an embedded dielectric cylinder using TR-DORT

In this paper, we study the problem of time reversal imaging of a dielectric object embedded inside another dielectric cylinder. The forward problem is solved using numerical simulation of scattering from a cross section of a cylinder by COMSOL and the multistatic data matrix (MDM) is obtained. The background Green's function (DGF) is computed by that of a point source near an infinitely long dielectric cylinder and TR-DORT is evaluated using this background DGF. Results demonstrate that while using a homogeneous DGF for imaging yields erroneous results, employing this Green's function the scatterer inside the cylinder is correctly imaged. Furthermore, small variation in permittivity of embedded dielectric cylinder is detected by studying the largest eigenvalue of the MDM matrix.
Development of novel core-shell dual-mesoporous silica nanoparticles for the production of high bioavailable controlled-release fenofibrate tablets

Abstract Novel core-shell dual-mesoporous silica nanoparticles (DMSN) were successfully prepared as a carrier in order to improve the dissolution of fenofibrate and obtain an oral highly bioavailable controlled-release drug delivery system using the osmotic pump technology. Fenofibrate was loaded into DMSN by an adsorption method. The solid state properties of fenofibrate in DMSN, before and after drug loading, were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption/desorption analysis (BET), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC). In vitro release tests showed that DMSN increased the dissolution rate of fenofibrate and produced zero-order release in push–pull osmotic pump tablets (OPT). The relative bioavailability of OPT was 186.9% in comparison with the commercial reference product. In summary, osmotic pump technology in combination with solid dispersion technology involving nanometer materials is a promising way for achieving the oral delivery of poorly water-soluble drugs.
Stereotactic radiotherapy of primary liver cancer and hepatic metastases

The purpose was to evaluate the clinical results of stereotactic radiotherapy in primary liver tumors and hepatic metastases. Five patients with primary liver cancer and 39 patients with 51 hepatic metastases were treated by stereotactic radiotherapy since 1997. Twenty-eight targets were treated in a “low-dose”-group with 3×10 Gy (n = 27) or 4×7 Gy (n = 1) prescribed to the PTV-encl. 65%-isodose. In a “high-dose”-group patients were treated with 3×12 − 12.5 Gy (n = 19; same dose prescription) or 1×26 Gy/PTV-enclosing 80%-isodose (n = 9). Median follow-up was 15 months (2–48 months) for primary liver cancer and 15 months (2–85 months) for hepatic metastases. While all primary liver cancers were controlled, nine local failures (3–19 months) of 51 metastases were observed resulting in an actuarial local control rate of 92% after 12 months and 66% after 24 months and later. A borderline significant correlation between dose and local control was observed (p = 0.077): the actuarial local control rate after 12 and 24 months was 86% and 58% in the low-dose-group versus 100% and 82% in the high-dose-group. In multivariate analysis high versus low-dose was the only significant factor predicting local control (p = 0.0089). Overall survival after 1 and 2 years was 72% and 32% for all patients and was impaired due to systemic progression of disease. No severe acute or late toxicity exceeding RTOG/EORTC-score 2 were observed. Stereotactic irradiation of primary liver cancer and hepatic metastases offers a locally effective treatment without significant complications in patients, who are not amenable for surgery. Patient selection is important, because those with low risk for systemic progression are more likely to benefit from this approach.
Securing Downlink Non-Orthogonal Multiple Access Systems by Trusted Relays

A downlink single-input single-output nonorthogonal multiple access system is considered in which a base station (BS) is communicating with two legitimate users in the presence of an external eavesdropper. A group of trusted cooperative half-duplex relay nodes, powered by the BS, is employed to assist the BS's transmission. The goal is to design relaying schemes such that the legitimate users' secrecy rate region is maximized subject to a total power constraint on the BS and the relays' transmissions. Three relaying schemes are investigated: cooperative jamming, decode-and-forward, and amplify-and-forward. Depending on the scheme, secure beamforming signals are carefully designed for the relay nodes that either diminish the eavesdropper's rate without affecting that of the legitimate users, or increase the legitimate users' rates without increasing that of the eavesdropper. The results show that there is no relaying scheme that fits all conditions; the best relaying scheme depends on the system parameters, namely, the relays' and eavesdropper's distances from the BS, and the number of relays. They also show that the relatively simple cooperative jamming scheme outperforms other schemes when the relays are far from the BS and/or close to the eavesdropper.
The Role of Social Capital during SMEs' Internationalization: Build, Maintain and Use of Networks

Internationalization has been an important topic for SMEs (small and medium-sized enterprises) around the world. Based on the size of the firm, internationalization creates chances and risks, advantages and disadvantages. Social capital serves as an important resource for SMEs to compensate certain disadvantages and higher risks they have in comparison with big firms. This paper takes a closer look at SMEs' social capital in form of networks and connections to key institutions (e.g. financial, governmental institutions) before and during the internationalization process. The study explores how SMEs build, maintain and use network resources in two countries with a different cultural and economic background. It depicts in detail the sources of social capital, private and business networks, and the influence on the access to other supporting resources. Social capital is predominantly used unknowingly as a resource. With the help of a multiple case study, this paper analyzes four firms from Germany and China which operate in different sectors. The results of the study clarify the role of social capital and demonstrate the importance of communication and their technology in this context.
Examining the effect of managing GHG emissions on business performance

Unprecedented climate changes menace not only the planetary ecosystem, but also the stability of the global economy. The European Union has for years promoted the transition of the economy towards a model of sustainable development, stimulating companies to adopt a strategic approach based on quality and environmental efficiency, rather than on quantity and reduction of costs. The aim of this study is to analyze how greater attention to the environmental effects of a company's activities (environmental management) and monitoring and reduction of CO2 emissions (emission management) can improve the company's economic performance. We analyze the financial data and greenhouse gas (GHG) emission figures for a sample of large Italian companies, searching for potential relations between increasing returns on capital invested and the reduction of pollutants. The results show that the companies examined are ever more attentive to environmental policies, and that those with a green vision achieve better operating performance. Copyright Â© 2017 John Wiley & Sons, Ltd and ERP Environment
Correlation Analysis Between Cotinine Hair Concentrations From Active Smokers and Nicotine Intake and Dependence

Objectives: To determine cotinine levels in hair samples collected from smokers and estimate their relationship with nicotine intake and nicotine dependence class according to the Fagerström dependence questionnaire. Design and Methods: Sixty-nine volunteers participated. They gave hair samples and answered questionnaires covering information related to smoking habits. Cotinine levels were determined by enzyme immunoassay after extraction from 20 mg of hair. Calibrators for the range 100 to 12,800 pg/mg were used. Results: Mean cotinine concentration was 2070.9 pg/mg (range, 469.4–10,188.6 pg/mg). There were significant correlations between cotinine levels in hair and the questionnaire results (rs = 0.325, P = 0.018) and with the number of cigarettes smoked in a day (rs = 0.717, P < 0.001). Although the correlation between questionnaire results and the number of cigarettes smoked per day was significant (rs = 0.565, P < 0.01), it was weaker than the association between cotinine levels and number of cigarettes smoked. Cotinine levels were lower in the group that smoked from 1 to 5 cigarettes per day (1104.1 ng/mg) compared with the other groups. Conclusions: Cotinine levels were more highly correlated with nicotine exposure than with the Fagerström questionnaire scores. It was found that interference from exogenous sources of contamination, such as hair dyes, is a limitation to estimate nicotine intake from hair analysis.
The Effect of Including Bone in Dixon-Based Attenuation Correction for 18F-Fluciclovine PET/MRI of Prostate Cancer

The objective of this study was to evaluate the effect of including bone in Dixon-based attenuation correction for 18F-fluciclovine PET/MRI of primary and recurrent prostate cancer. Methods: 18F-fluciclovine PET data from 2 PET/MRI studies—one for staging of high-risk prostate cancer (28 patients) and one for diagnosis of recurrent prostate cancer (81 patients)—were reconstructed with a 4-compartment (reference) and 5-compartment attenuation map. In the latter, continuous linear attenuation coefficients for bone were included by coregistration with an atlas. The SUVmax and mean 50% isocontour SUV (SUViso) of primary, locally recurrent, and metastatic lesions were compared between the 2 reconstruction methods using linear mixed-effects models. In addition, mean SUVs were obtained from bone marrow in the third lumbar vertebra (L3) to investigate the effect of including bone attenuation on lesion–to–bone marrow SUV ratios (SUVRmax and SUVRiso; recurrence study only). The 5-compartment attenuation maps were visually compared with the in-phase Dixon MR images for evaluation of bone registration errors near the lesions. P values of less than 0.05 were considered significant. Results: Sixty-two lesions from 39 patients were evaluated. Bone registration errors were found near 19 (31%) of these lesions. In the remaining 8 primary prostate tumors, 7 locally recurrent lesions, and 28 lymph node metastases without bone registration errors, use of the 5-compartment attenuation map was associated with small but significant increases in SUVmax (2.5%; 95% confidence interval [CI], 2.0%–3.0%; P < 0.001) and SUViso (2.5%; 95% CI, 1.9%–3.0%; P < 0.001), but not SUVRmax (0.2%; 95% CI, −0.5%–0.9%; P = 0.604) and SUVRiso (0.2%; 95% CI −0.6%–1.0%; P = 0.581), in comparison to the 4-compartment attenuation map. Conclusion: The investigated method for atlas-based inclusion of bone in 18F-fluciclovine PET/MRI attenuation correction has only a small effect on the SUVs of soft-tissue prostate cancer lesions, and no effect on their lesion–to–bone marrow SUVRs when using signal from L3 as a reference. The attenuation maps should always be checked for registration artifacts for lesions in or close to the bones.
Investment Opportunities Forecasting: A Genetic Programming-Based Dynamic Portfolio Trading System under a Directional-Change Framework

This paper presents an autonomous effective trading system devoted to the support of decision-making processes in the financial market domain. Genetic programming (GP) has been used effectively as an artificial intelligence technique in the financial field, especially for forecasting tasks in financial markets. In this paper, GP is employed as a means of automatically generating short-term trading rules on financial markets using technical indicators and fundamental parameters. The majority of forecasting tools use a fixed physical timescale, which makes the flow of price fluctuations discontinuous. Therefore, using a fixed physical timescale may expose investors to risks, due to their ignorance of some significant activities. Instead of using fixed timescales for this purpose, the trading rules are generated under a directional-change (DC) event framework.We examine the profitability of the trading systems for the Saudi Stock Exchange, and evaluate the GP forecasting performance under a DC framework through agent-based simulation market index trading. The performance of the forecasting model is compared with a number of benchmark forecasts, namely the buy-and-hold and technical analysis trading strategies. Our numerical results show that the proposed GP model under a DC framework significantly outperforms other traditional models based on fixed physical timescales in terms of portfolio return.
Reticulocyte and Erythrocyte Binding-Like Proteins Function Cooperatively in Invasion of Human Erythrocytes by Malaria Parasites

ABSTRACT Plasmodium falciparum causes the most severe form of malaria in humans and invades erythrocytes using multiple ligand-receptor interactions. Two important protein families involved in erythrocyte binding are the erythrocyte binding-like (EBL) and the reticulocyte binding-like (RBL or P. falciparum Rh [PfRh]) proteins. We constructed P. falciparum lines lacking expression of EBL proteins by creating single and double knockouts of the corresponding genes for eba-175, eba-181, and eba-140 and show that the EBL and PfRh proteins function cooperatively, consistent with them playing a similar role in merozoite invasion. We provide evidence that PfRh and EBL proteins functionally interact, as loss of function of EBA-181 ablates the ability of PfRh2a/b protein antibodies to inhibit merozoite invasion. Additionally, loss of function of some ebl genes results in selection for increased transcription of the PfRh family. This provides a rational basis for considering PfRh and EBL proteins for use as a combination vaccine against P. falciparum. We immunized rabbits with combinations of PfRh and EBL proteins to test the ability of antibodies to block merozoite invasion in growth inhibition assays. A combination of EBA-175, PfRh2a/b, and PfRh4 recombinant proteins induced antibodies that potently blocked merozoite invasion. This validates the use of a combination of these ligands as a potential vaccine that would have broad activity against P. falciparum.