Miracle-dz/UniFAR-FTUs huggingface dataset:
CAUSES AND MANAGEMENT OF STRESS AT WORK

Stress has been defined in different ways over the years. Originally, it was conceived of as pressure from the environment, then as strain within the person. The generally accepted definition today is one of interaction between the situation and the individual. It is the psychological and physical state that results when the resources of the individual are not sufficient to cope with the demands and pressures of the situation. Thus, stress is more likely in some situations than others and in some individuals than others. Stress can undermine the achievement of goals, both for individuals and for organisations (box 1). View this table: Box 1: The problem of stress Signs of stress can be seen in people's behaviour, especially in changes in behaviour. Acute responses to stress may be in the areas of feelings (for example, anxiety, depression, irritability, fatigue), behaviour (for example, being withdrawn, aggressive, tearful, unmotivated), thinking (for example, difficulties of concentration and problem solving) or physical symptoms (for example, palpitations, nausea, headaches). If stress persists, there are changes in neuroendocrine, cardiovascular, autonomic and immunological functioning, leading to mental and physical ill health (for example anxiety, depression, heart disease) (box 2, fig 1). 1 View this table: Box 2 : Signs of stress Figure 1 A model of stress at work.1 Situations that are likely to cause stress are those that are unpredictable or uncontrollable, uncertain, ambiguous or unfamiliar, or involving conflict, loss or performance expectations. Stress may be caused by time limited events, such as the pressures of examinations or work deadlines, or by ongoing situations, such as family demands, job insecurity, or long commuting journeys. Resources that help meet the pressures and demands faced at work include personal characteristics such as coping skills (for example, problem solving, assertiveness, time management) and the work situation such as a good working environment and social support. These resources can be …
CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function

DNA methylation is a major epigenetic mark with important roles in genetic regulation. Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non-CpG sites (CpA, CpT, and CpC). The general functions of CpG and non-CpG methylation include gene silencing or activation depending on the methylated regions. CpG and non-CpG methylation are found throughout the whole genome, including repetitive sequences, enhancers, promoters, and gene bodies. Interestingly, however, non-CpG methylation is restricted to specific cell types, such as pluripotent stem cells, oocytes, neurons, and glial cells. Thus, accumulation of methylation at non-CpG sites and CpG sites in neurons seems to be involved in development and disease etiology. Here, we provide an overview of CpG and non-CpG methylation and their roles in neurological diseases.
The Zebrafish Breathes New Life into the Study of Tuberculosis

Tuberculosis (TB) is a global health emergency. Up to one-third of the world’s population is infected with Mycobacterium tuberculosis, and the pathogen continues to kill 1.5 million people annually. Currently, the means for preventing, diagnosing, and treating TB are unsatisfactory. One of the main reasons for the poor progress in TB research has been a lack of good animal models to study the latency, dormancy, and reactivation of the disease. Although sophisticated in vitro and in silico methods suitable for TB research are constantly being developed, they cannot reproduce the complete vertebrate immune system and its interplay with pathogens and vaccines. However, the zebrafish has recently emerged as a useful alternative to more traditional models, such as mice, rabbits, guinea pigs, and non-human primates, for studying the complex pathophysiology of a mycobacterial infection. The model is based on the similarity between Mycobacterium marinum – a natural fish pathogen – and M. tuberculosis. In both zebrafish larvae and adult fish, an infection with M. marinum leads to the formation of macrophage aggregates and granulomas, which resemble the M. tuberculosis infections in humans. In this review, we will summarize the current status of the zebrafish model in TB research and highlight the advantages of using zebrafish to dissect mycobacterial virulence strategies as well as the host immune responses elicited against them. In addition, we will discuss the possibilities of using the adult zebrafish model for studying latency, dormancy, and reactivation in a mycobacterial infection.
Computerized tomographic assessment and clinical evaluation in shoulder instability treated with the Latarjet-Patte procedure using one screw and washer.

BACKGROUND The Latarjet-Patte (L-P) procedure is indicated in anterior instability of the shoulder with a glenoid or humeral bone loss. Our purpose is to evaluate clinical outcome and computerized tomographic (CT) findings as position and resorption of the graft and articular degeneration. METHODS From 2006 to 2009 50 patients underwent to L-P, 48 was contacted by telephone and 26 were available for follow-up (3 to 6 years). Quick-DASH and Rowe scores was used, 22 patients perform CT. RESULTS None of contacted patients reported a new dislocation. The clinical outcome in the 26 followed patients was excellent: mean Quick DASH score: 1.9; mean ROWE score was 94.7. CT scans showed no evidence of articular degeneration of humeral head. There was partial resorption of the graft in 13 patients. We found a correlation between the zone of partial resorption and position of the graft. CONCLUSIONS CT scan is appropriate to study position and the healing of coracoid graft. A correct choice of where to place the graft together with a wide bone contact and stable synthesis does not cause degenerative changes after 6 years in our series. LEVEL OF THE EVIDENCE IV.
Article Title: P2x1 and P2x5 Subunits Form the Functional P2x Receptor in Mouse Cortical Astrocytes P2x 1 and P2x 5 Subunits Form the Functional P2x Receptor in Mouse Cortical Astrocytes

This paper is made available online in accordance with publisher policies. Please scroll down to view the document itself. Please refer to the repository record for this item and our policy information available from the repository home page for further information. To see the final version of this paper please visit the publisher's website. Access to the published version may require a subscription. ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical dissociation. Brain slices were prepared from transgenic mice that express enhanced green fluorescent protein under the control of the human glial fibrillary acidic protein promoter. Astrocytes were studied by whole-cell voltage clamp. Exogenous ATP evoked inward currents in 75 of 81 astrocytes. In the majority (ϳ65%) of cells, ATP-induced responses comprising a fast and delayed component; in the remaining subpopulation of astrocytes, ATP triggered a smoother response with rapid peak and slowly decaying plateau phase. The fast component of the response was sensitive to low concentrations of ATP (with EC 50 of ϳ40 nM). All ATP-induced currents were blocked by pyridoxal-phosphate-6-azophenyl-2Ј,4Ј-disulfonate (PPADS); they were insensitive to ivermectin. Quantitative real-time PCR demonstrated strong expression of P2X 1 and P2X 5 receptor subunits and some expression of P2X 2 subunit mRNAs. The main properties of the ATP-induced response in cortical astrocytes (high sensitivity to ATP, biphasic kinetics, and sensitivity to PPADS) were very similar to those reported for P2X 1/5 heteromeric receptors studied previously in heterologous expression systems.
Static Control-Flow Analysis of User-Driven Callbacks in Android Applications

Android software presents many challenges for static program analysis. In this work we focus on the fundamental problem of static control-flow analysis. Traditional analyses cannot be directly applied to Android because the applications are framework-based and event-driven. We consider user-event-driven components and the related sequences of callbacks from the Android framework to the application code, both for lifecycle callbacks and for event handler callbacks. We propose a program representation that captures such callback sequences. This representation is built using context-sensitive static analysis of callback methods. The analysis performs graph reachability by traversing context-compatible interprocedural control-flow paths and identifying statements that may trigger callbacks, as well as paths that avoid such statements. We also develop a client analysis that builds a static model of the application's GUI. Experimental evaluation shows that this context-sensitive approach leads to substantial precision improvements, while having practical cost.
Enculturating Cells: The Anthropology, Substance, and Science of Stem Cells

The ongoing enculturation of stem cells with culturally specific meaning in different global locales is receiving critical anthropological attention. As an anthropological subject and cultural object, stem cells continually rearrange practices that range from scientific discourse to political governance. As a unique and dynamic area of research, stem cell science straddles political, economic, and technological as well as ethical and religious dimensions around the globe. The article examines how cross-cultural differentials in research, development, and clinical application have produced hitherto unseen ethical and moral complexities. The examples range from highly restrictive regimes of control and governance of stem cell research in certain locales to global clinical contexts offering experimental stem cell therapies. The article examines these complex sites of political contestation, ethical variation, knowledge production, and economic calculation under four main conceptual sections: intersections an.
Queueing Analysis of a Large-Scale Bike Sharing System through Mean-Field Theory

The bike sharing systems are fast increasing as a public transport mode in urban short trips, and have been developed in many major cities around the world. A major challenge in the study of bike sharing systems is that large-scale and complex queueing networks have to be applied through multi-dimensional Markov processes, while their discussion always suffers a common difficulty: State space explosion. For this reason, this paper provides a mean-field computational method to study such a large-scale bike sharing steps: Firstly, a multi-dimensional Markov process is set up for expressing the states of the bike sharing system, and the empirical process of the multi-dimensional Markov process is given to partly overcome the difficulty of state space explosion. Based on this, the mean-field equations are derived by means of a virtual time-inhomogeneous M(t)/M(t)/1/K queue whose arrival and service rates are determined by the mean-field computation. Secondly, the martingale limit is employed to investigate the limiting behavior of the empirical process, the fixed point is proved to be unique so that it can be computed by means of a nonlinear birth-death process, the asymptotic independence of this system is discussed simply, and specifically, these lead to numerical computation of the steady-state probability of the problematic (empty or full) stations. Finally, some numerical examples are given for valuable observation on how the steady-state probability of the problematic stations depends on some crucial parameters of the bike sharing system.
Genetic Algorithm Based Optimal Control for a 6-DOF Non Redundant Stewart Manipulator

Applicability of tuning the controller gains for Stewart manipulator using genetic algorithm as an efficient search technique is investigated. Kinematics and dynamics models were introduced in detail for simulation purpose. A PD task space control scheme was used. For demonstrating technique feasibility, a Stewart manipulator numerical-model was built. A genetic algorithm was then employed to search for optimal controller gains. The controller was tested onsite a generic circular mission. The simulation results show that the technique is highly convergent with superior performance operating for different payloads.
Being with People and Being Alone in Late Life: Costs and Benefits for Everyday Functioning

Being alone and being with people are both important determinants for adaptation in the everyday life of elderly people. We examined the relationship between social contact (engagement in activities alone or in the presence of others), difficulties experienced with daily activities when with people or when alone, everyday satisfaction, and self-reported autonomy. Greater levels of social contact are associated with greater everyday satisfaction as long as participants report no difficulty in daily activities. However, greater levels of social contact are associated with lower self-reported autonomy among very old participants (85-104 years) and social contact is unrelated to self-reported autonomy among old participants (70-84 years). The findings suggest that the compensatory use of social resources and the selective narrowing of social contact in daily activities contribute to adaptive everyday functioning in later life.
Predictors of employment after successful kidney transplantation – a population‐based study

Abstract: Introduction: Kidney transplantation is currently the treatment of choice for end‐stage renal disease. As the successful transplantation improves the physical and mental quality of life, it is expected that the transplant recipient should play a productive role in the society. The present study evaluates the occurrence and predictors of employment after kidney transplantation.
Cloud computing adoption assessment model (CAAM)

Cloud Computing (Clouds) is a new trend in IT, not yet widely adopted by large-scale organisations extensive IT infrastructure and complex IT processes as they find it difficult to adopt Clouds. There are technical and socio-technical challenges that need to be addressed before adoption. There is a need for an assessment framework that would assist adoption by evaluating the organisation, its key capabilities and processes affected by Clouds. The objective of this research study is to develop a model that helps organisations in assessing and improving their readiness for Cloud Computing. Primary data in this research are user concerns and issues that are barrier in the adoption of Clouds. The primary data will be collected using Systematic Literature Review (SLR) methodology. Interviews with senior executives and IT Managers are planned to validate the findings of the SLR. The anticipated outcome of this project will be Cloud Computing Adoption Assessment Model (CAAM) that will help organisations to adopt and integrate Clouds with Enterprise IT, define new capabilities, identify their organisational readiness and provide strategies for successful adoption. The case study method will be used for evaluating CAAM in conjunction with organisations willing to adopt cloud computing. Three case studies are planned to evaluate the effectiveness of CAAM in assessing organisation's readiness for the adoption of Cloud Computing.
A Chick Embryo With a yet Unclassified Type of Cephalothoracopagus Malformation and a Hypothesis for Explaining its Genesis

Cephalothoracopagus embryos are conjoined twins, who share parts of their heads, necks and bodies. Our study aims at presenting a detailed morphological analysis of a cephalothoracopagus chick embryo of developmental stage 31. Because none of the existing theories can explain the genesis of the phenotype of this embryo, we also suggest a hypothesis, which explains it. Beside the cephalothoracopagus embryo, we investigated five control embryos. With the aid of the high‐resolution episcopic microscopy (HREM) technique, we created digital volume data and three‐dimensional (3D) computer models of the organs and arteries of the embryos. We used the 3D models for topological analysis and for measuring the diameters of the great intrathoracic arteries. The malformed embryo showed two body backs, each containing a notochord, spinal cord and dorsal aorta. The body backs continued into separated lower bodies. The embryo had a single, four‐chambered heart, single respiratory tract and single upper alimentary tract. The topology of the pharyngeal arch arteries was normal, and the diameters of these arteries were similar to that of the control embryos. We classified the embryo we investigated as a yet unknown malformation and suggest a hypothesis explaining its genesis.
Short-term hourly price forward curve prediction using neural network and hybrid ARIMA-NN model

Even though the electricity HPFC (Hourly Price Forward Curve) is still surprisingly under-researched the prediction of electricity prices is highly important in order to keep power plants profitable or in order to optimize the electricity purchases based on future customers demand. In this work two methods to model and predict HPFC based on neural networks will be proposed and compared to more common time series approach - specifically ARIMA model. In the first method the neural network is applied to model the price at desired time as a function of some past observations and also to capture the seasonal character of the data. The second method uses hybrid model which consist of an ARIMA model combined with neural network. The ARIMA is used to capture linear patterns in the data. Then the neural network is used to model remaining non-linear residuals. In this case the whole process is done on deseasonalized data set. Both methods provide more accurate predictions than standard time series approach (in this case ARIMA model) and results clearly state that the neural network approach is a valid alternative for forecasting (not just) economic time series.
Toward A Grounded Theory Of Female Leader Development In The Military

While leadership is arguably an essential part of organizational functioning, only recently has the academic literature produced a theory of leadership development. Furthermore, the majority of leadership research has (1) focused on male leaders and (2) been top-down and theory-driven. Through the current pilot study, I attempted to address these gaps in prior research by producing a grounded theory of female leader development within a military context. The iterative processes of open coding, axial coding, and selective coding were implemented to discover the theory from the bottom-up. Results indicated that the central category in female leader development in the military was relationships. In addition, engaged experiences and incorporating feedback played important roles in the development process. Findings of this study were compared to previous research and theory development in the area of leadership development. The propositions which emerged in this study may provide a basis for future empirical research in the study of female leader development in the military.
Efficacy of Autologous Bone Marrow Concentrate for Knee Osteoarthritis with and without Adipose Graft

Introduction. We investigated the use of autologous bone marrow concentrate (BMC) with and without an adipose graft, for treatment of knee osteoarthritis (OA). Methods. Treatment registry data for patients who underwent BMC procedures with and without an adipose graft were analyzed. Pre- and posttreatment outcomes of interest included the lower extremity functional scale (LEFS), the numerical pain scale (NPS), and a subjective percentage improvement rating. Multivariate analyses were performed to examine the effects of treatment type adjusting for potential confounding factors. The frequency and type of adverse events (AE) were also examined. Results. 840 procedures were performed, 616 without and 224 with adipose graft. The mean LEFS score increased by 7.9 and 9.8 in the two groups (out of 80), respectively, and the mean NPS score decreased from 4 to 2.6 and from 4.3 to 3 in the two groups, respectively. AE rates were 6% and 8.9% in the two groups, respectively. Although pre- and posttreatment improvements were statistically significant, the differences between the groups were not. Conclusion. BMC injections for knee OA showed encouraging outcomes and a low rate of AEs. Addition of an adipose graft to the BMC did not provide a detectible benefit over BMC alone.
The CHOPIN project: Cooperation between human and rObotic teams in catastrophic incidents

Mobile robots can be an invaluable aid to human first responders (FRs) in catastrophic incidents, as they are expendable and can be used to reduce human exposure to risk in search and rescue (SaR) missions, as well as attaining a more effective response. Moreover, parallelism and robustness yielded by multi-robot systems (MRS) may be very useful in this kind of spatially distributed tasks, which are distributed in space, providing augmented situation awareness (SA). However, this requires adequate cooperative behaviors, both within MRS teams and between human and robotic teams. Collaborative context awareness between both teams is crucial to assess information utility, efficiently share information and build a common and consistent SA. This paper presents the foreseen research within the CHOPIN research project, which aims to address these scientific challenges and provide a proof of concept for the cooperation between human and robotic teams in SaR scenarios.
A Quantitative Theory of Feeling

Resume Le “sens du sentiment” est defini pour comprendre toute l'experience “sentie,” l'experience affective et emotive non exceptees, et une theorie neuralogique est offerte pour le sens qui ne comprend pas le concept de “qualite”. On fait la correlation de pression-douleur avec l'intensite et les autres variables sont la duree, la densite, et l'extension. Chaud-froid varie d'une maniere caracteristique des formes non-thermales de l'experience mais ne comprend pas de difference fondamentale. La localisation est un processus appris dependent du locus cortical. Nulle experience n'est simple. Des objets semblables de stimulus, de temps en temps, etablissent de semblables conditions dans les tissus et celles-ci sont accompagnees de semblables experiences psychologiques. Ainsi on generalise et nomme les types les plus frequents. Les experiences sont plus compliquees par les activites reflexes etablies, surtout les elements effectifs et emotifs de l'experience. L'evidence psychologique donnee est completee par.
Interference From Additional Props in an Elicited Imitation Task: When in Sight, Firmly in Mind

A modified elicited imitation task was used to examine the development of the ability to resist and overcome interference in the 2nd and 3rd years of life. In the modified task, distractor props were included in the test array, so that children could imitate the modeled sequence but could also produce actions with the additional props provided, which was predicted to produce interference. Both experiments examined differences between 20-month-olds and 27-month-olds. In Experiment 1, the modified task was compared to the standard elicited imitation procedure; inclusion of distractor props was detrimental to performance, consistent with interference. However, younger and older children were equally affected by the manipulation. In Experiment 2, the task was made more difficult by adding more distractor props. Older children were better able to make use of cues to overcome interference. The effect of the distractor props was different when they were drawn from sequences that shared props with the test sequence. We speculate that this stems from differing demands on cognitive flexibility.