Miracle-dz/UniFAR-FTUs huggingface dataset:
No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting.

AIMS In clopidogrel-treated patients undergoing coronary stenting, high on-treatment platelet reactivity was linked to a higher risk of stent thrombosis (ST). Platelet response to clopidogrel is significantly influenced by genetic factors. Recently published findings showed a highly significant impact of a common polymorphism (Q192R) within the paraoxonase-1 (PON1) gene on clopidogrel treatment efficacy but no influence of the CYP2C19*2 genetic variant as previously demonstrated. The aim of this study was to assess the impact of the PON1 Q192R genotype in parallel to that of CYP2C19*2 on the antiplatelet effect of clopidogrel and the risk of ST in clopidogrel-treated patients. METHODS AND RESULTS In 1524 patients undergoing percutaneous coronary intervention, ADP-induced platelet aggregation was assessed in relation to PON1 Q192R and CYP2C19*2 genotypes. The clinical impact of genetic variants was investigated by comparing genotype frequencies of both genetic variants in a registry of 127 cases with early ST vs. an early ST-free control cohort (n = 1439). For PON1 Q192R genotypes, platelet aggregation values were similar across all genotype groups (P = 0.65). For CYP2C19*2 genotypes, significantly higher aggregation values were found in CYP2C19 wt/*2 and *2/*2 patients when compared with wt/wt allele carriers (P < 0.0001). Comparing genotype frequencies between ST cases and controls, no differences were observed for PON1 Q192R genotype distributions (P = 0.23), whereas the genotype distribution differed for CYP2C19*2 genotypes (P = 0.019). CONCLUSION The PON1 Q192R genotype did not influence platelet response to clopidogrel or the risk of ST in clopidogrel-treated patients, whereas the CYP2C19*2 genotype impacted on both antiplatelet effect of clopidogrel and risk of coronary ST.
Trying to Revalue Elementary Social Studies: Dilemmas and Insights

In 2007, the authors conducted a case study of 13 teachers across seven elementary schools. We learned that, due to pressures of the No Child Left Behind Act (NCLB, 2002) and state mandated testing, these schools were akin to reading academies—focused chiefly on the teaching of reading skills. They promised to share their results with local administrators and teachers, initiating the reconsideration of elementary social studies. To this end, they revisited school sites, revealed their findings, and offered to “fit into” ongoing discussions of curricular change. They attempted to engage teachers in courageous conversations, or honest, frank appraisal of current conditions. Eventually, they talked with approximately 100 K-6 teachers, principals, and district administrators. Framing their inquiry in Giddens (1984) theory of structuration, they present their efforts to build collaborative relationships in three cases of narrative inquiry. They follow it with dilemmas and insights for the field organized into five considerations: courageous conversation, curricular control, integration, social studies advocacy, and courting schools.
NON-AXISYMMETRIC CORIOLIS VIBRATORY GYROSCOPE WITH WHOLE ANGLE, FORCE REBALANCE, AND SELF-CALIBRATION

This paper presents detailed performance status and projections for the silicon MEMS Quadruple Mass Gyroscope (QMG) – a unique high Q, lumped mass, mode-symmetric Class II Coriolis Vibratory Gyroscope (CVG) with interchangeable whole angle, self-calibration, and force rebalance mechanizations. Analysis of a QMG sealed without getter with a Q-factor of 1e3 reveals an Angle Random Walk (ARW) of 0.02 deg/rt-hr limited only by the fundamental Mechanical-Thermal Noise (MTN). Propagation of a detailed noise model to a QMG sealed with getter at a Q-factor of 1e6 (previously demonstrated) showed better than Navigation Grade ARW of 0.001 deg/rt-hr. Combination of the very low ARW with the mode-symmetry enabled self-calibration substantiates the navigation grade performance capacity of the SiMEMS QMG.
Design of Microstrip Lowpass Filter Using Delta Stub Based on Transfer Function Analysis

A b s t r a c t A new compact microstrip lowpass filter with ultra-wide stopband and sharp roll-off using delta stub is presented. A meander transmission line is used to achieve a compact microstrip lowpass filter also coupled U-shaped resonators have been adopted to increase stopband width in this filter. The LC equivalent circuit and transfer function are calculated to archive The most important transmission zero formula. A designed filter with 3 dB cutoff frequency at 1.22 GHz has been fabricated and measured. The proposed filter shows a ultra-wide stopband of 159% (referred to a suppression degree of 30 dB), also results show that a sharp roll-off is 102.7 while a high figure-of-merit of 27628 is obtained.
Learning to Read Empirical Articles in General Psychology

Many students, particularly underprepared students, struggle to identify the essential information in empirical articles. We describe a set of assignments for instructing general psychology students to dissect the structure of such articles. Students in General Psychology I read empirical articles and answered a set of general, factual questions applicable to nearly any empirical article. Students in General Psychology II read empirical articles and wrote two-page summaries based on the question set from General Psychology I. In both courses, student competence on the assignment and confidence in their ability to complete the assignment improved, suggesting that these assignments aid students in learning to dissect empirical articles.
Convergence Models for Lattice Joint Process Estimators and Least Squares Algorithms

A simple model characterizing the convergence properties of an adaptive digital lattice filter using gradient algorithms has been reported [ 11. This model is extended to the least mean square (LMS) lattice joint process estimator [SI, and to the least squares (LS) lattice and “fast” Kalman algorithms [9] -[16]. The models in each case are compared with computer simulation. The single-stage LMS lattice analysis presented in [l ] is also applied to the LS lattice. Results indicate that for stationary inputs, the LMS lattice and LS algorithms exhibit similar behavior. I.
Shotgun Redox Proteomics: Identification and Quantitation of Carbonylated Proteins in the UVB-Resistant Marine Bacterium, Photobacterium angustum S14

UVB oxidizes proteins through the generation of reactive oxygen species. One consequence of UVB irradiation is carbonylation, the irreversible formation of a carbonyl group on proline, lysine, arginine or threonine residues. In this study, redox proteomics was performed to identify carbonylated proteins in the UVB resistant marine bacterium Photobacterium angustum. Mass-spectrometry was performed with either biotin-labeled or dinitrophenylhydrazide (DNPH) derivatized proteins. The DNPH redox proteomics method enabled the identification of 62 carbonylated proteins (5% of 1221 identified proteins) in cells exposed to UVB or darkness. Eleven carbonylated proteins were quantified and the UVB/dark abundance ratio was determined at both the protein and peptide levels. As a result we determined which functional classes of proteins were carbonylated, which residues were preferentially modified, and what the implications of the carbonylation were for protein function. As the first large scale, shotgun redox proteomics analysis examining carbonylation to be performed on bacteria, our study provides a new level of understanding about the effects of UVB on cellular proteins, and provides a methodology for advancing studies in other biological systems.
Lidar observations of polar mesospheric clouds at South Pole: Seasonal variations

Polar mesospheric clouds (PMCs) were observed above the geographic South Pole by an Fe Boltzmann temperature lidar from 11 Dec 99 to 24 Feb 00. During this 76‐day period 297 h of observations were made on 33 different days and PMCs were detected 66.5% of the time. The mean PMC peak backscatter ratio, peak volume backscatter coefficient, total backscatter coefficient, layer centroid altitude, and layer rms width are 50.59±2.33, 2.70±0.12 × 10−9 m−1sr−1, 3.61±0.22 × 10−6 sr−1, 85.49±0.09 km, and 0.71±0.03 km, respectively. The PMCs are highest near summer solstice when upwelling over the pole is strongest. The altitudes are 2–4 km higher than that typically observed elsewhere, including the North Pole. After solstice the mean altitudes decreases by about 64 m/day as the upwelling weakens.
The potential of peer assisted learning as a tool for facilitating social and academic integration

Research into the transition of first year students in higher education (HE) confirms that student integration into the academic community is a primary condition for student success (Borglum & Kubala, 2000; Tinto & Pusser, 2006; Tovar, Simon & Lee, 2009; Stebleton, Soria & Huesman, 2014). It is also crucial that it is combined with peer support if students are going to settle into university life (Hamshire, Jack, Prowse, & Wibberley, 2015a). This article seeks to explore the potential value and purposes of peer assisted learning (PAL) as a tool to increase the social and academic integration of first year university students. Focus group interviews (n=16) were conducted between the spring and autumn of 2013 with first-year students (n=93) enrolled in the Faculty of Educational Sciences (Psychology and Educational sciences) at the Free University of Brussels. By using the method of appreciative inquiry (AI), respondents suggested that peer-assisted learning methods are important tools for enhancing social and academic integration.AÂ In this sense, tutoring and mentoring need to address specific criteria on at least two organisational dimensions (Topping & Ehly, 2001):AÂ (a) objectives of the subject and (b) contact installation. This article aims to prompt further discussion on the potential, value and purposes of peer-assisted learning programmes for integration.
Iran, America and Iranian American Community in Firoozeh Jazayeri Dumas' Funny in Farsi

Post 9/11 the United States of America concerns the reconstruction of already demonized identities of Arabs and Middle-eastern cultures. Postcolonial works reside in their rendering a tragic or serious image of Middle Easterners to bring the Western (American) audience into sympathizing with the Middle Eastern ethnicities. Could it be the case that a fundamentally humorous (not derogatory) depiction might contribute to easing such cultural tensions? Firoozeh Jazayeri Dumas’ works stand out as critically acclaimed and successful works familiarizing the American audience with the more humane, likeable, sweet and funny aspects of the Iranians and Iranian culture, and the hardships of being an Iranian immigrant and becoming a hybrid individual. This article explores the already-hybridized self and psyche of Firoozeh as an Iranian American. She writes about her mother land and her residence country and comparing the way she has written about them can help readers understand how one can make peace between different parts of her identity.
The neuroanatomy of subthreshold depressive symptoms in Huntington's disease: a combined diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) study

Background Depressive symptoms are prominent psychopathological features of Huntington's disease (HD), making a negative impact on social functioning and well-being. Method We compared the frequencies of a history of depression, previous suicide attempts and current subthreshold depression between 61 early-stage HD participants and 40 matched controls. The HD group was then split based on the overall HD group's median Hospital Anxiety and Depression Scale-depression score into a group of 30 non-depressed participants (mean 0.8, s.d. = 0.7) and a group of 31 participants with subthreshold depressive symptoms (mean 7.3, s.d. = 3.5) to explore the neuroanatomy underlying subthreshold depressive symptoms in HD using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI). Results Frequencies of history of depression, previous suicide attempts or current subthreshold depressive symptoms were higher in HD than in controls. The severity of current depressive symptoms was also higher in HD, but not associated with the severity of HD motor signs or disease burden. Compared with the non-depressed HD group DTI revealed lower fractional anisotropy (FA) values in the frontal cortex, anterior cingulate cortex, insula and cerebellum of the HD group with subthreshold depressive symptoms. In contrast, VBM measures were similar in both HD groups. A history of depression, the severity of HD motor signs or disease burden did not correlate with FA values of these regions. Conclusions Current subthreshold depressive symptoms in early HD are associated with microstructural changes – without concomitant brain volume loss – in brain regions known to be involved in major depressive disorder, but not those typically associated with HD pathology.
Stix-Fusion: A Probabilistic Stixel Integration Technique

In summer 2013, a Mercedes S-Class drove completely autonomously for about 100 km from Mannheim to Pforzheim, Germany, using only close-to-production sensors. In this project, called Mercedes Benz Intelligent Drive, stereo vision was one of the main sensing components. For the representation of free space and obstacles we relied on the so called Stixel World, a generic 3D intermediate representation which is computed from dense disparity images. In spite of the high performance of the Stixel World in most common traffic scenes, the availability of this technique is limited. For instance under adverse weather, rain or even spray water on the windshield results in erroneous disparity images which generate false Stixel results. This can lead to undesired behavior of autonomous vehicles. Our goal is to use the Stixel World for a robust free space estimation and a reliable obstacle detection even during difficult weather conditions. In this paper, we meet this challenge and fuse the Stixels incrementally into a reference grid map. Our new approach is formulated in a Bayesian manner and is based on existence estimation methods. We evaluate our new technique on a manually labeled database with emphasis on bad weather scenarios. The number of structures which are detected mistakenly within free space areas is reduced by a factor of two whereas the detection rate of obstacles increases at the same time.
Chaperonin filaments: their formation and an evaluation of methods for studying them.

Chaperonins are multisubunit protein complexes that can be isolated from cells as high-molecular-weight structures that appear as double rings in the electron microscope. We recently discovered that chaperonin double rings isolated from the hyperthermophilic archaeon Sulfolobus shibatae, when incubated at physiological temperatures in the presence of ATP and Mg2+, stacked into filaments; we hypothesized that these filaments are related to filaments seen inside S. shibatae cells and that chaperonins exist as filaments in vivo (J. D. Trent et al., 1997, Proc. Natl. Acad. Sci. USA 94, 5383-5388). This paper elucidates the conditions under which we have observed S. shibatae chaperonins to form filaments and evaluates native polyacrylamide gel electrophoresis (PAGE), TEM, spectrophotometry, and centrifugation as methods for studying these filaments. We observed that in the presence of Mg2+ combined with ATP, ADP, ATPgammaS, or GTP, native PAGE indicated that chaperonin subunits assembled into double rings and that the conformation of these double rings was effected by nucleotide binding, but we saw no indication of chaperonin filament formation. Under these same conditions, however, TEM, spectroscopy, and centrifugation methods indicated that chaperonin subunits and double rings had assembled into filaments. We determined that this discrepancy in the representation of the chaperonin structure was due to the native PAGE method itself. When we exposed chaperonin filaments to the electrophoretic field used in native PAGE, the filaments dissociated into double rings. This suggests that TEM, spectrophotometry, and centrifugation are the preferred methods for studying the higher-order structures of chaperonins, which are likely to be of biological significance.
No evidence of inbreeding avoidance despite demonstrated survival costs in a polygynous rodent

Individuals are generally predicted to avoid inbreeding because of detrimental fitness effects. However, several recent studies have shown that limited inbreeding is tolerated by some vertebrate species. Here, we examine the costs and benefits of inbreeding in a largely polygynous rodent, the yellow‐bellied marmot (Marmota flaviventris). We use a pedigree constructed from 8 years of genetic data to determine the relatedness of all marmots in our study population and examine offspring survival, annual male reproductive success, relatedness between breeding pairs and the effects of group composition on likelihood of male reproduction to assess inbreeding in this species. We found decreased survival in inbred offspring, but equal net reproductive success among males that inbred and those that avoided it. Relatedness between breeding pairs was greater than that expected by chance, indicating that marmots do not appear to avoid breeding with relatives. Further, male marmots do not avoid inbreeding: males mate with equal frequency in groups composed of both related and unrelated females and in groups composed of only female relatives. Our results demonstrate that inbreeding can be tolerated in a polygynous species if the reproductive costs of inbreeding are low and individuals that mate indiscriminately do not suffer decreased reproductive success.
Featured Graphic. Mushrooming Jiedaos, Growing Cities: An Alternative Perspective on Urbanizing China

With more than 15 million new urban residents entering its cities every year, China is witnessing one of the greatest socioeconomic and environmental transformations in human history. In addition to these ongoing changes, urbanization in China often involves a significant political dimension, as the government would purposely accord city status to settlements, regardless of their developmental level: Largely rural settlements (eg, Zhen) could be accorded with the city status (eg, Jiedao) overnight by administrative power. Such redesignation is nontrivial as city status often translates into real socioeconomic changes; city status is closely linked to the land-use quota, provision of public services, local governments’ legislature power, as well as residents’ hukou. While socioeconomic and environmental aspects of Chinese cities have been analyzed extensively with aggregated statistics and/or remote sensing data (Deng et al, 2012), little is known about the shifting political geography of Chinese cities: that is, where new city status is being granted. It is this lacuna that our project aims to fill. We focus on the basic building block of a city proper in China: Jiedao (subdistricts). China has three township-level administrative units: Jiedao in the urban area and its counterparts in the rural side (Xiang, townships; and Zhen, towns). The re-designation of city status often involves Zhen and Jiedao: Zhens are considered as ‘next in the pipeline’ for city status and turned into Jiedaos when there is a political and/or economic need. We geocoded the 41 871 township-level units based on the Population Census of China, and estimated the spatial extent of individual units with Voronoi diagrams for the years of 2000 and 2010. The end product is a first map of ‘mushrooming’ Jiedaos in China. The total number of Jiedaos has grown from 5510 to 6923—a 25% increase—during the period 2000–10. Most new cities-proper have been created around major urban regions along the economically more developed eastern coast [eg, Yangtze River Delta, Pearl River Delta, Shandong Peninsula, and Beijing–Tianjin–Hebei (BTH)]. Other regions with noticeable growth are Central Henan in Central China, as well as the Chengdu–Chongqing corridor in West China. We also mapped out the distribution of Zhens: regions in East and Central China (eg, Shandong and Henan) feature predominantly, revealing the potential for future urban expansion. As city status often translates into real urban growth, we conjecture that the uneven geography of mushrooming Jiedaos would entrench the already huge East–West divide in China.
La Fragmentation Horizontale Revisitée: Prise en Compte de l'Interaction de Requêtes

Résumé. La principale caractéristique des requêtes définies sur un entrepôt de données relationnel (EDR) est le fait que leurs jointures passent systématiquement par la table des faits. Cette situation favorise l’interaction entre les requêtes. Cette interaction a été largement exploitée par les algorithmes d’optimisation de requêtes dans les bases de données traditionnelles, connue sous le nom d’optimisation multi-requêtes. Dans les EDR, cette interaction a été utilisée pour définir des méthodes de sélection des vues matérialisées. Dans cet article, nous revisitons le problème de sélection de schéma de fragmentation horizontale. Après un état de l’art, où nous soulignons le fait que les algorithmes existants ignorent l’interaction entre les requêtes, nous proposons un nouvel algorithme basé sur cette interaction. Sa principale caractéristique est l’utilisation d’une structure de données incrémentale considérant l’interaction. Il utilise le principe d’élection des requêtes pour aiguiller le processus de fragmentation et propager le gain au mieux sur l’ensemble des requêtes de la charge. Finalement, une étude expérimentale est conduite pour prouver l’efficacité de notre approche.
Spatially covariant theories of a transverse, traceless graviton: Formalism

General relativity is a covariant theory of two transverse, traceless graviton degrees of freedom. According to a theorem of Hojman, Kuchar, and Teitelboim, modifications of general relativity must either introduce new degrees of freedom or violate the principle of general covariance. In this paper, we explore modifications of general relativity that retain the same number of gravitational degrees of freedom, and therefore explicitly break general covariance. Motivated by cosmology, the modifications of interest maintain spatial covariance. Demanding consistency of the theory forces the physical Hamiltonian density to obey an analogue of the renormalization group equation. In this context, the equation encodes the invariance of the theory under flow through the space of conformally equivalent spatial metrics. This paper is dedicated to setting up the formalism of our approach and applying it to a realistic class of theories. Forthcoming work will apply the formalism more generally.