Miracle-dz/UniFAR-FTUs huggingface dataset:
An accurate high-resolution technique for distributed sensing based on frequency-domain Brillouin scattering

A novel high-resolution temperature/strain profile reconstruction approach, based on frequency-domain stimulated Brillouin scattering (SBS) measurements in single-mode optical fibers, is proposed and experimentally demonstrated. The proposed technique is based on an accurate modeling of the SBS interaction in the frequency domain, where even the modulation of the acoustic wave involved in the scattering process is taken into account. The reconstruction algorithm determines the unknown profile by minimizing a cost function representing the error between the measured and the model data. Experimental results show that the proposed technique allows accurate temperature/strain profile reconstructions, even when dealing with modulation frequencies rising above the natural Brillouin gain linewidth. This permits us to achieve a spatial resolution below 1m.
3D simulation of silicon-based single-electron transistors

Single electron transistors based on silicon nanopillars were investigated with regard to their current voltage characteristics. The simulations make use of the commercial quantum simulator nextnano++, but extend its functionality for the calculation of tunneling currents. A comparison with results obtained by the Monte-Carlo based tunneling simulator SIMON is presented. Investigations include the variation of geometrical quantities and quantum dot doping.
Analysis of an influenza A virus mutant with a deletion in the NS segment

The influenza virus host range mutant CR43-3, derived by recombination from the A/Alaska/6/77 and the cold-adapted and temperature-sensitive A/Ann Arbor/6/60 viruses, has previously been shown to possess a defect in the NS gene. To characterize this defect, nucleotide sequence data were obtained from cloned cDNAs. The CR43-3 NS gene was found to be 854 nucleotides long and to derive from the NS gene of the A/Alaska/6/77 parent virus by an internal deletion of 36 nucleotides. Direct sequencing of RNA 8 of CR43-3 virus confirmed that the deletion in the NS1-coding region was not an artifact that was generated during the cloning procedure. Protein analysis indicated that the NS1 protein of CR43-3 virus was synthesized in equal amounts in the restrictive (MDCK) cells as well as in the permissive (PCK) host cells. Also, indirect immunofluorescence studies of virus-infected cells showed that the NS1 protein of CR43-3 virus, like that of the parent viruses, accumulates in the nuclei of both cell systems. Although no differences in synthesis or localization of the NS1 protein could be detected, a consistent reduction in M1 protein was noted in CR43-3 virus-infected, nonpermissive cells as compared with that of the permissive host. Since analysis of the CR43-3 virus required us to obtain the NS nucleotide sequence of the 1977 isolate A/Alaska/6/77, we were able to compare this sequence with those of corresponding genes of earlier strains. The result of this analysis supports the idea of a common lineage of human influenza A viruses isolated over a 43-year period.
Prediction of novel systems components in cell cycle regulation in malaria parasite by subnetwork alignments

With 300-500 clinical cases and 1-2 million deaths yearly, malaria contributes to enormous health care and economic burden worldwide. The advent of high throughput -omics technologies is driving new approaches to the identification of potential antimalarial targets. In this paper, we propose a neighborhood subnetwork alignment approach to uncover the network components involved in cell cycle regulation of the malaria parasite Plasmodium falciparum and to assign function to previously unannotated proteins.
Ka-band low noise amplifiers based on InAlN/GaN technologies

Low noise amplifiers in receivers are usually addressed by III-V (narrow bandgap) technologies: but when the receivers are subject to EM exposure or jamming, the need for protection devices before the active low noise amplifier (LNA) degrades the overall noise figure, and decreases the effective radio link budget. This vulnerability of the LNA can be overcome thanks to robust designs or robust technologies. Nitride technologies are investigated for power modules in transmitters and stand as promising solutions to avoid the use of limiters for robust low noise circuits in receivers. This work focuses on HF noise in InAlN/GaN HEMT devices and circuits for Ka-band SATCOM applications. Different versions of LNA have been designed at 30 GHz, in hybrid and MMIC technologies. For these designs, 1-stage and 3-stages LNAs have been realized; 1-stage amplifiers are designed to assess and study the stress tolerance under RF signal, whereas 3-stages LNAs are designed as demonstrators of operational module for receiver's blocks (Gain>20dB featuring the lowest noise figure achievable).
Effects of immobility on sensory and motor symptoms of restless legs syndrome

Restless legs syndrome (RLS) is defined by an irresistible need to move associated with leg paresthesia. Two additional features are essential for diagnosis: (1) worsening of symptoms at rest with temporary relief by activity, and (2) worsening of symptoms during the evening and/or during the night. The suggested immobilization test (SIT) has been developed to evaluate the presence of these criteria. This test quantifies leg movements and leg discomfort during a 1‐hour period of immobility prior to bedtime. We used the SIT to evaluate the effects of immobility on leg discomfort and leg movements experienced by 19 patients with RLS and 19 control subjects. Results show that immobility significantly worsens both leg discomfort and periodic leg movements (PLM) in patients with RLS but not in controls. Patients with RLS showed a higher leg discomfort score (32.6 ± 15.1 mm vs. 5.7 ± 7.9 mm; P < 0.00001), a greater maximum leg discomfort value (63.4 ± 27.4 mm vs. 13.7 ± 23.0 mm; P < 0.00001) and a greater PLM index (88.4 ± 62.6 vs. 10.4 ± 20.6; P < 0.00004) than control subjects. These results further validate the use of the SIT as a diagnostic and research tool for RLS and confirm the contention of the International RLS study group that RLS symptoms worsen at rest. © 2001 Movement Disorder Society.
Multicast Transmission with Energy-Proportional Power-Gating Scheme for Wireless Interconnects NoC

To reduce the energy consumption as well as the thermal problem of wireless routers (WRs) in a wireless network-on-chip (WiNoC) for high performance computing (HPC) is a critical problem for energy efficiency since WRs consume a lot of energy and generate a lot of heat. Using multicast transmission is one of the techniques to achieve HPC in a full-connected WiNoC (full-WiNoC) architecture (i.e., one-time transmission to multiple receivers). This paper presents a problem that in multicast transmission non-multicast members (i.e., WRs) do not switch off their power in full-WiNoC and waste their energy. To solve this problem, we propose a power-gating (PG) technique for WRs to transmit multicast, called energy-proportional multicast scheme (EMS), in full-WiNoC for energy efficiency. EMS can achieve a lower energy consumption based on temporally switching off those non-multicast WRs by using PG technique during multicast transmissions. It shows that an EMS-designed full-WiNoC for multicast can reduce 91% energy consumption at most as compared with the wired interconnects NoC in a 16 WRs case. It also shows that full-WiNoC with EMS can reduce 65% energy consumption than full-WiNoC without EMS. This investigation encourages the design of EMS in full-WiNoC for HPC on energy efficiency.
Palliative Cancer Patients’ experience of Physical Activity

Results from pilot studies indicate that palliative cancer patients report increased well-being and less fatigue after physical activity. This study aimed to explore how palliative cancer patients experienced physical activity. A qualitative design with semi-structured interviews was used. Eleven palliative cancer patients over 18 years old with different diagnoses and Eastern Cooperative Oncology Group Scale performance status levels of between 1 and 3 were interviewed. Four main themes emerged: routines of everyday life, less fatigue, professional guidance, and hope. The first theme comprised two categories: something to do, and being together with others in a similar situation. The theme professional guidance also comprised two categories: the physiotherapist as tutor, and the physiotherapist as motivator. Some cancer patients in palliative care who participated in physical activity experienced less fatigue and enhanced energy. Physical activity helps to bring structure to everyday life and gives a feeling of hope for the future.
Line-Based Correction of Radial Lens Distortion

A method for determining the radial distortion parameters of a camera is presented. The technique is based on the analysis of distorted images of straight lines and does not require the determination of point correspondence between a scene and an image of that scene. The method is described in detail, including information on the line detection method and the optimization procedure used to estimate the distortion parameters. Quantitative and qualitative experimental results using both synthetic and real image data show that the technique is effective.
Tuberculosis and the HIV epidemic: increasing annual risk of tuberculous infection in Kenya, 1986-1996.

OBJECTIVES The purpose of this study was to assess the impact of the increased incidence of tuberculosis (TB) due to HIV infection on the risk of TB infection in schoolchildren. METHODS Tuberculin surveys were carried out in randomly selected primary schools in 12 districts in Kenya during 1986 through 1990 and 1994 through 1996. Districts were grouped according to the year in which TB notification rates started to increase. HIV prevalence in TB patients and changes in TB infection prevalence were compared between districts. RESULTS Tuberculous infection prevalence rates increased strongly in districts where TB notification rates had increased before 1994 (odds ratio = 3.1, 95% confidence interval = 2.3, 4.1) but did not increase in districts where notification rates had increased more recently or not at all. HIV prevalence rates in TB patients were 50% in districts with an early increase in notification rates and 28% in the other study districts. CONCLUSIONS Countries with an increasing prevalence of HIV infection will need additional resources for TB control, not only for current patients but also for the patients in additional cases arising from the increased risk of TB infection.
1 THE TMPRSS 2 : ERG REARRANGEMENT , ERG EXPRESSION , AND PROSTATE CANCER OUTCOMES : A COHORT STUDY AND META-ANALYSIS

THE TMPRSS2:ERG REARRANGEMENT, ERG EXPRESSION, AND PROSTATE CANCER OUTCOMES: A COHORT STUDY AND META-ANALYSIS Andreas Pettersson, Rebecca E. Graff, Scott R. Bauer, Michael Pitt, Rosina T. Lis, Edward C. Stack, Neil E. Martin, Lauren Kunz, Kathryn L. Penney, Azra H. Ligon, Catherine Suppan, Richard Flavin, Howard D. Sesso, Jennifer R. Rider, Christopher Sweeney, Meir Stampfer, Michelangelo Fiorentino, Philip W. Kantoff, Martin Sanda, Edward Giovannucci, Eric L. Ding, Massimo Loda, Lorelei A. Mucci *These authors contributed equally to this work Affiliations: 1) Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA 2) Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA 3) Department of Medicine, University of California San Francisco, San Francisco, CA, USA 4) Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA 5) Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA 6) Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA 7) Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA 8) Department of Pathology, National University of Ireland, Galway, Galway, Ireland 9) Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA 10) Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA 11) Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
Overstress-Free Charge Pump White LED Driver

 Abstract—This paper presented a white light emitting diode (LED) driver that utilized charge pump in boosting the input voltage. The output voltage had been made sure that it was sufficient enough to overcome the forward voltage of the LED as well as provide voltage headroom for the transistors in every LED channel branch. The charge pump and its peripheral circuit, the clock booster circuit, do not suffer from gate-oxide overstress. Gate oxide overstress arose when the potential difference of a certain junction of a transistor exceeded the supply voltage. Moreover, this design can accommodate four (4) LEDs arranged in parallel. In comparison with the other DC-DC converters such as buck and/or boost, this work does not utilize an inductor. The non-utilization of inductor has offered an advantage in terms of lesser board area consumption and minimal height. The test chip was implemented using 0. 35μm 5V 2P4M CMOS process. The chip area was measured to be 2350.05 μm x 2496. 70μm with an efficiency of 51%.
Team Description Paper GPR-2 D 2012

 This document describes a simulated robotic soccer team (GPR-2D). The team is implemented using an Artificial Intelligence (AI) strategy to modify the behavior of players of one team of soccer robots of the RoboCup 2D simulation category. This strategy used is a Reinforcement Learning (RL) algorithm, Q-learning. This algorithm define how each agent should act according to the characteristics of the opponent players, selecting the best action to take in a given state of the environment.
Design of experiments in CAD: context and new data sets for ISCAS'99

This paper introduces the background and motivation for the two special sessions at ISCAS'99. The sessions bring together eight papers, each rooted in the methodology of experimental design, and contributed by collaborating teams of distributed participants. The paper briefly outlines the premises of the companion papers that follow, provides a brief description of a typical experimental design, and introduces a design for archival of data sets and results that are to be readily accessible on the Web.
Supplementation of selenium-enriched yeast attenuates age-dependent transcriptional changes of heart in mitochondrial DNA mutator mice

Background: Age is a major risk factor in developing heart diseases and has been associated with profound transcriptional changes in mammalian tissues. Low tissue selenium has recently been linked to several age-related diseases, including cardiovascular disease. This study investigated the global effects of age and dietary supplementation of selenium on heart transcriptional profiles in POLG mutator mice. Methods : Heart transcription profiles from young (2-month-old) and old (13-month-old) animals fed either a control diet or a diet supplemented with 1.0 mg selenium from selenium-enriched yeast (SP)/kg diet were obtained and validated using microarray and real-time RT-PCR techniques. Results : Aging led to significant transcriptional changes, where the expression of 1942 genes in old animals was changed by a fold change larger than 2.0, when compared to young animals. Age-regulated genes are associated with cardiovascular system development, immune and inflammatory response, and cellular oxidative stress response. Multiple genes linked with cardiomyocyte apoptosis, hypertrophy, and cardiac fibrosis, such as Myh7, Lcn2, Spp1, and Serpine1, were significantly up-regulated in old animals. SP supplementation also caused significant transcriptional changes in the heart, especially in old mice where many age-dependent transcriptional changes were totally or partially reversed by SP. Upstream regulator analysis further indicated that genes for Foxo1 and Foxo3, two transcriptional regulators involved in the regulation of cardiac muscle remodeling, were significantly activated by SP, suggesting that Foxo-mediated transcriptional activities play important roles in the anti-aging properties of SP. Conclusions : Results of this study indicate that SP supplementation attenuated age-related transcriptional changes in the heart of old POLG mice, which implies a potential clinical application of dietary selenium in preventing decline of cardiac function in old animals. Key words: Aging, heart, gene expression, selenium
Periodic leg movements during sleep and wakefulness in narcolepsy

The objectives of the study were to measure the prevalence of periodic leg movements during NREM and REM sleep (PLMS) and while awake (PLMW) and to assess the impact of PLMS on nocturnal sleep and daytime functioning in patients with narcolepsy. One hundred and sixty‐nine patients with narcolepsy and 116 normal controls matched for age and gender were included. Narcoleptics with high and low PLMS indices were compared to assess the impact of PLMS on sleep and Multiple Sleep Latency Test (MSLT) variables. More narcoleptics than controls had a PLMS index greater than 5 per hour of sleep (67% versus 37%) and an index greater than 10 (53% versus 21%). PLMS indices were higher both in NREM and REM sleep in narcoleptic patients, but the between‐group difference was greater for REM sleep. A significant increase of PLMS index was also found with aging in both narcoleptic patients and controls. PLMW indices were also significantly higher in narcoleptic patients. Patients with an elevated index of PLMS had a higher percentage of stage 1 sleep, a lower percentage of REM sleep, a lower REM efficiency and a shorter MSLT latency. The present study demonstrates a high frequency of PLMS and PLMW in narcolepsy, an association between the presence of PLMS and measures of REM sleep and daytime functioning disruption. These results suggest that PLMS represent an intrinsic feature of narcolepsy.
Evaluation of enterprise vitality and model of enterprise commercial age

Enterprise commercial age is an important branch of enterprise bionics. Japanese scholars put forward the concept of commercial age and built a model to measure it in the 1960s. Chinese scholars have devoted a lot of energy in this area, however, there is still lack of empirical research to some extent by now.
A Comparison of Two Parasitoids (Hymenoptera: Encyrtidae) of the Vine Mealybug: Rapid, Non-Discriminatory Oviposition is Favored when Ants Tend the Host

ABSTRACT The encyrtid parasitoids Coccidoxenoides perminutus Girault and Anagyrus nr. sp. pseudococci (Girault) were compared in the laboratory as parasitoids of the mealybug Planococcus ficus (Signoret). Female C. perminutus preferred second-instar P. ficus for oviposition, and produced more adult offspring (149.3 per female) than A. nr. sp. pseudococci (54.1 per female). The development time, from egg to adult emergence, of C. perminutus decreased with increasing constant temperatures between 18.5 and 30.1°C; at lower (12.0 and 15.0°C) and higher (31.1, 32.7, and 34.2°C) temperatures, the parasitoid did not develop. The lower threshold was calculated by linear methods to be 10.97°C, and the thermal constant was calculated to be 507.98 degree—days. The development times of C. perminutus were longer than those of A. nr. sp. pseudococci, and C. perminutus had narrower temperature tolerances than P. ficus or A. pseudococci. Argentine ants (Linepithema humile (Mayr)) reduced the amount of time C. perminutus foraged on mealybug-infested squash, but did not affect the number of oviposition attempts or offspring produced, whereas Argentine ants reduced A. nr. sp. pseudococci foraging time, oviposition attempts, and number of offspring obtained. Overall, the results suggest that under certain conditions, including optimal conditions of temperature and host-stage availability, C. perminutus outperforms A. nr. sp. pseudococci, and may be an effective augmentative control agent even when ants are tending the hosts. However, temperature limitations and host-stage selection behaviors would reduce C. perminutus performance in the field, and in the absence of ants, other parasitoids may be favored.
Expanding Role of the Jumonji C Domain as an RNA Hydroxylase*

JmjC (Jumonji C) domain-containing proteins are known to be an extensive family of Fe(II)/2-oxoglutarate-dependent oxygenases involved in epigenetic regulation of gene expression by catalyzing oxidative demethylation of methylated histones. We report here that a human JmjC protein named Tyw5p (TYW5) unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxywybutosine, in tRNAPhe by catalyzing hydroxylation. The finding provides an insight into the expanding role of JmjC protein as an RNA hydroxylase.
Topography as Historiography: Petrarch, Chaucer, and the Making of Medieval Rome

The inspiration for The Decline and Fall of the Roman Empire, as Edward Gibbon famously recalls in his memoirs, came from ruins: “It was at Rome on the fifteenth of October 1764, as I sat musing amidst the ruins of the Capitol while the barefooted fryars were singing Vespers in the temple of Jupiter, that the idea of writing the decline and fall of the City first started to my mind. ”1 In its topographical specificity—the Capitol lies in ruins while the temple of Jupiter has been taken over by “fryers”—this scene captures the broadest historical argument of Gibbon’s enormous work: Rome fell to ruin when the city became Christian and its new leaders destroyed or neglected the former monuments of its classical past. Nearly a century later another great historian, Jacob Burckhardt, followed Gibbon by visiting Rome during his own grand tour in 1846; but in the famous ruins Burckhardt found inspiration for a very different history from Gibbon’s. While the ruins prompt Gibbon to mourn the end of a glorious empire, they fill Burckhardt, as he writes in a letter at the time, with unexpected pleasure: “Part of the pleasure of Rome is that it keeps one perpetually guessing and arranging the ruins of the ages that lie so mysteriously, layer upon layer. ”2 This pleasure of uncovering the past is one that Burckhardt would assign in his own monumental work, The Civilization of the Renaissance in Italy (1860), to the Italian humanists, for whom “the material knowledge of old Rome” inspired and defined a new epoch of cultural rebirth, the Renaissance.3 Between them, Gibbon and Burckhardt create the most enduring modern narrative of the premodern era by establishing the borders that divide and define its three constitutive epochs: where Gibbon’s subject is the border between classical and medieval, which marks a decline and fall, Burckhardt’s is the no-less irrefragable border between medieval and Renaissance, which marks a cultural reawakening and rebirth. As the above passages show,
Cellular robotic collision-free path planning

Presents a massively parallel, connectionist model for cellular robotic collision-free path planning. A number of cellular robots (represented by via points) are distributed along the initial path arbitrarily set up, and move toward the final positions to form an optimal collision-free path, following the locally defined rules. The local rules for individual cellular robots are based on the gradient of the potential field due to the polyhedral obstacles and the distances to the neighboring cellular robots. The cellular robotic path planning provides massive parallelism and has power to effectively deal with path planning of three dimensional case with translational and rotational motions. Finally, the algorithm incorporates simulated annealing to solve a local minimum problem. <<ETX>>