Miracle-dz/UniFAR-FTUs huggingface dataset:
Lexical access via letter naming in a profoundly alexic and anomic patient: A treatment study

We report the results of a letter naming treatment designed to facilitate letter-by-letter reading in an aphasic patient with no reading ability. Patient M.R. 's anomia for written letters reflected two loci of impairment within visual naming: impaired letter activation from print (a deficit commonly seen in pure alexic patients who read letter by letter) and impaired access to phonology via semantics (documented in a severe multimodality anomia). Remarkably, M.R. retained an excellent ability to pronounce orally spelled words, demonstrating that abstract letter identities could be activated normally via spoken letter names, and also that lexical phonological representations were intact when accessed via spoken letter names. M.R. 's training in oral naming of written letters resulted in significant improvement in her oral naming of trained letters. Importantly, as M.R. 's letter naming improved, she became able to employ letter-by-letter reading as a compensatory strategy for oral word reading. M.R. 's success in letter naming and letter-by-letter reading suggests that other patients with a similar pattern of spared and impaired cognitive abilities may benefit from a similar treatment. Moreover, this study highlights the value of testing the pronunciation of orally spelled words in localizing the source of prelexical reading impairment and in predicting the functional outcome of treatment for impaired letter activation in reading. (JINS, 1998, 4, 595–607.)
Adult life expectancy trends in the era of antiretroviral treatment in rural Uganda (1991–2012)

Objective:To estimate the impact of antiretroviral therapy (ART) on population-wide adult life expectancy. Study design:A population-based open cohort study with repeated HIV status measurements and registration of vital events in Southwestern Uganda (1991–2012). Methods:Nonparametric survival analysis techniques are used for estimating trends in the adult life expectancy of the general population (aged 15 and above), the adult life expectancy by HIV status, and the adult life expectancy deficit. The life expectancy deficit is estimated as the difference between overall life expectancy and life expectancy of the HIV-negative population. All estimates are disaggregated by sex. Results:Between 1991–1993 and 2009–2012, population-wide adult life expectancy increased from 39.3 [95% confidence interval (CI): 35.9–42.8] to 56.1 years (95% CI: 54.0–58.5) in women, and from 38.6 (95% CI: 35.4–42.1) to 51.4 years (95% CI: 49.2–53.7) in men. Most of the adult life expectancy gains coincide with the introduction of ART in 2004; as evidenced by an increase in the adult life expectancy of people living with HIV between 2000–2002 and 2009–2012 of 22.9 and 20.0 years for women and men, respectively. Over the whole period of observation, the adult life expectancy deficit associated with HIV decreased from 16.1 (95% CI: 12.7–19.8) to 6.0 years (95% CI: 4.1–7.8) among women, and from 16.0 (95% CI: 12.1–19.9) to 2.8 years (95% CI: 1.2–4.6) among men. Conclusion:Population-wide life expectancy increased substantially, largely driven by reductions in HIV-related mortality. Women have gained more adult life years than men since the introduction of ART, but the burden of HIV in terms of the life years lost is still larger for women than it is for men.
Data embedding for geo-tagging any contents in smart device

In recent years, the GPS location information can be effortlessly obtained through smart devices such as smart phone, tablet PC and camera. The obtained GPS information can be utilized for two main purposes, namely geo-tagging and tracking. GPS enabled various innovative applications such as photo album arrangement, tracking of taxi/bus, estimation of calories burned during an outdoor cycling session, etc. However, the storage of GPS information has not been addressed sufficiently and hence it can be easily tampered. This study surveys the current storage method for GPS location information. The drawbacks are identified and the data embedding approach is proposed as a more flexibly and practical way in storing the GPS location information. In particular, data embedding methods are proposed to embed the GPS information in text, audio, image and video contents that can be handled by a smart device. Discussion on possible applications are also presented.
Relational maintenance strategies and equity in marriage

Utilizing equity theory, this study extends previous research on maintenance strategies. The manner in which relational maintenance strategies are reported and perceived is examined. It was hypothesized that maintenance strategies are used more in equitable relationships than in relationships characterized by underbenefitedness. Further, the use of maintenance efforts by individuals in overbenefited relationships was explored. In addition, this study examined the relative contribution of self‐reported maintenance strategies, perception of partners’ maintenance strategies, and equity in predicting the relational characteristics. Overall, the level of felt equity was found to be related to individuals’ use of, and perceptions of partners’ use of, maintenance strategies in a pattern consistent with equity theory. However, the findings varied somewhat when relying on wives’ versus husbands’ equity judgments. Moreover, self‐reported maintenance strategies as well as perceptions of partners’ maintenance strateg.
Tissue-Specific Fatty Acids Response to Different Diets in Common Carp (Cyprinus carpio L.)

Fish depend on dietary fatty acids (FA) to support their physiological condition and health. Exploring the FA distribution in common carp (Cyprinus carpio), one of the world's most consumed freshwater fish, is important to understand how and where FA of different sources are allocated. We investigated diet effects on the composition of polar and neutral lipid fatty acids (PLFA and NLFA, respectively) in eight different tissues (dorsal and ventral muscle, heart, kidney, intestine, eyes, liver and adipose tissue) of common carp. Two-year old carp were exposed to three diet sources (i.e., zooplankton, zooplankton plus supplementary feeds containing vegetable, VO, or fish oil, FO) with different FA composition. The PLFA and NLFA response was clearly tissue-specific after 210 days of feeding on different diets. PLFA were generally rich in omega-3 polyunsaturated FA and only marginally influenced by dietary FA, whereas the NLFA composition strongly reflected dietary FA profiles. However, the NLFA composition in carp tissues varied considerably at low NLFA mass ratios, suggesting that carp is able to regulate the NLFA composition and thus FA quality in its tissues when NLFA contents are low. Finally, this study shows that FO were 3X more retained than VO as NLFA particularly in muscle tissues, indicating that higher nutritional quality feeds are selectively allocated into tissues and thus available for human consumption.
Evaluating auditory stream segregation of SAM tone sequences by subjective and objective psychoacoustical tasks, and brain activity

Auditory stream segregation refers to a segregated percept of signal streams with different acoustic features. Different approaches have been pursued in studies of stream segregation. In psychoacoustics, stream segregation has mostly been investigated with a subjective task asking the subjects to report their percept. Few studies have applied an objective task in which stream segregation is evaluated indirectly by determining thresholds for a percept that depends on whether auditory streams are segregated or not. Furthermore, both perceptual measures and physiological measures of brain activity have been employed but only little is known about their relation. How the results from different tasks and measures are related is evaluated in the present study using examples relying on the ABA- stimulation paradigm that apply the same stimuli. We presented A and B signals that were sinusoidally amplitude modulated (SAM) tones providing purely temporal, spectral or both types of cues to evaluate perceptual stream segregation and its physiological correlate. Which types of cues are most prominent was determined by the choice of carrier and modulation frequencies (fmod) of the signals. In the subjective task subjects reported their percept and in the objective task we measured their sensitivity for detecting time-shifts of B signals in an ABA- sequence. As a further measure of processes underlying stream segregation we employed functional magnetic resonance imaging (fMRI). SAM tone parameters were chosen to evoke an integrated (1-stream), a segregated (2-stream), or an ambiguous percept by adjusting the fmod difference between A and B tones (Δfmod). The results of both psychoacoustical tasks are significantly correlated. BOLD responses in fMRI depend on Δfmod between A and B SAM tones. The effect of Δfmod, however, differs between auditory cortex and frontal regions suggesting differences in representation related to the degree of perceptual ambiguity of the sequences.
Quality of the home learning environment during preschool age – Domains and contextual conditions

The quality of the home learning environment has been proven to be of major importance for child development, but little is known about the role of domain specificity in promoting early childhood learning at home and its dependence on family background. This article presents a framework of the home learning environment in early childhood that includes three domains of stimulation (i.e. family support, stimulation in literacy and stimulation in numeracy) and their contextual conditions. The study examines the extent to which the structural characteristics and educational beliefs of the family are connected to educational processes taking place in the home learning environment during preschool age. Results show that general educational processes of the home learning environment operate independently of structural characteristics and parental educational beliefs, whereas the domain-specific educational processes of the home learning environment are more strongly related to the structural characteristics and parental educational beliefs. A model of the home learning environment should thus always include different domains of stimulation (general and domain-specific) presented as parallel cases.
PDE7B is involved in nandrolone decanoate hydrolysis in liver cytosol and its transcription is up-regulated by androgens in HepG2

Most androgenic drugs are available as esters for a prolonged depot action. However, the enzymes involved in the hydrolysis of the esters have not been identified. There is one study indicating that PDE7B may be involved in the activation of testosterone enanthate. The aims are to identify the cellular compartments where the hydrolysis of testosterone enanthate and nandrolone decanoate occurs, and to investigate the involvement of PDE7B in the activation. We also determined if testosterone and nandrolone affect the expression of the PDE7B gene. The hydrolysis studies were performed in isolated human liver cytosolic and microsomal preparations with and without specific PDE7B inhibitor. The gene expression was studied in human hepatoma cells (HepG2) exposed to testosterone and nandrolone. We show that PDE7B serves as a catalyst of the hydrolysis of testosterone enanthate and nandrolone decanoate in liver cytosol. The gene expression of PDE7B was significantly induced 3- and 5- fold after 2 h exposure to 1 μM testosterone enanthate and nandrolone decanoate, respectively. These results show that PDE7B is involved in the activation of esterified nandrolone and testosterone and that the gene expression of PDE7B is induced by supra-physiological concentrations of androgenic drugs.
Defining the Metaphor 1 Scaffolding : Defining the Metaphor

Scaffolding embodies much of the activity that goes on in classroom teaching and teacherlearner interaction. As the metaphor of scaffolding has become popularized, it has often been adopted as a general term that is used to describe all types of support and guidance offered in the classroom. Due to its popularization, scaffolding has become difficult to define, and perhaps even unbounded from its theoretical underpinnings (Palincsar, 1988). This paper revisits the concept of scaffolding by (1) introducing its origin and connection to sociocultural theory, (2) reviewing some of the empirical and pedagogical endeavors that expanded the definition over the last forty years, and (3) considering its current application to the language classroom. It concludes with suggestions regarding some directions for future research on the role of scaffolding in the field of second language teaching and learning.
Transport characteristics and transporter‐based drug–drug interactions of TM‐25659, a novel TAZ modulator

The in vitro metabolic stability and transport mechanism of TM‐25659, a novel TAZ modulator, was investigated in human hepatocytes and human liver microsomes (HLMs) based on the preferred hepatobiliary elimination in rats. In addition, the in vitro transport mechanism and transporter‐mediated drug–drug interactions were evaluated using oocytes and MDCKII cells overexpressing clinically important drug transporters. After a 1 h incubation in HLMs, 92.9 ± 9.5% and 95.5 ± 11.6% of the initial TM‐25659 remained in the presence of NADPH and UDPGA, respectively. Uptake of TM‐25659 readily accumulated in human hepatocytes at 37 ºC (i.e. 6.7‐fold greater than that at 4 ºC), in which drug transporters such as OATP1B1 and OATP1B3 were involved. TM‐25659 had a significantly greater basal to apical transport rate (5.9‐fold) than apical to basal transport rate in the Caco‐2 cell monolayer, suggesting the involvement of an efflux transport system. Further studies using inhibitors of efflux transporters and overexpressing cells revealed that MRP2 was involved in the transport of TM‐25659. These results, taken together, suggested that TM‐25659 can be actively influxed into hepatocytes and undergo biliary excretion without substantial metabolism. Additionally, TM‐25659 inhibited the transport activities of OATP1B1 and OATP1B3 with IC50 values of 36.3 and 25.9 μm, respectively. TM‐25659 (100 μm) increased the accumulation of the probe substrate by 160% and 213%, respectively, through the inhibition of efflux function of P‐gp and MRP2. In conclusion, OATP1B1, OATP1B3, P‐gp and MRP2 might be major transporters responsible for the pharmacokinetics and drug–drug interaction of TM‐25659, although their contribution to in vivo pharmacokinetics needs to be further investigated. Copyright © 2013 John Wiley & Sons, Ltd.
On Dialectics and Human Decency: Education in the dock

Abstract Set against the backdrop of the contemporary crisis of capitalism and world-historical events, this article examines the advance of globalized imperialism from the perspective of a Marxist-humanist approach to pedagogy known as ‘revolutionary critical pedagogy’ enriched by liberation theology. It is written as an epistolic manifesto to the transnational capitalist class, demanding that those who willingly serve its interests reconsider their allegiance and calling for a planetary revolution in the way that we both think about capitalism and how education and religion serves to reproduce it at the peril of both students and humanity as a whole.
Auto-Tuning GEMV on Many-Core GPU

GPUs provide powerful computing ability especially for data parallel algorithms. However, the complexity of the GPU system makes the optimization of even a simple algorithm difficult. Different parallel algorithms or optimization methods on a GPU often lead to very different performances. The matrix-vector multiplication routine for general dense matrices (GEMV) is a building block for many scientific and engineering computations. We find that the implementations of GEMV in CUBLAS 4.0 or MAGMA are not efficient, especially for small matrix or fat matrix (a matrix with small number of rows and large number of columns). In this paper, we propose two new algorithms to optimize GEMV on Fermi GPU. Instead of using only one thread, we use a warp to compute an element of vector y. We also propose a novel register blocking method to accelerate GEMV on GPU further. The proposed optimization methods for GEMV are comprehensively evaluated on the matrices with different sizes. Experiment results show that the new methods can achieve over 10x speedup for small square matrices and fat matrices compared to CUBLAS 4.0 or MAGMA, and the new register blocking method can also perform better than CUBLAS 4.0 or MAGMA for large square matrices. We also propose a performance-tuning framework on how to choose an optimal algorithm of GEMV for an arbitrary input matrix on GPU.
Functional Neuroanatomical Differences Between Adults and School-Age Children in the Processing of Single Words

A critical issue in developmental cognitive neuroscience is the extent to which the functional neuroanatomy underlying task performance differs in adults and children. Direct comparisons of brain activation in the left frontal and extrastriate cortex were made in adults and children (aged 7 to 10 years) performing single-word processing tasks with visual presentation; differences were found in circumscribed frontal and extrastriate regions. Conceivably, these differences could be attributable exclusively to performance discrepancies; alternatively, maturational differences in functional neuroanatomy could exist despite similar performance. Some of the brain regions examined showed differences attributable to age independent of performance, suggesting that maturation of the pattern of regional activations for these tasks is incomplete at age 10.
Distributed servers approach for large-scale secure multicast

In order to offer backward and forward secrecy for multicast applications (i.e., a new member cannot decrypt the multicast data sent before its joining and a former member cannot decrypt the data sent after its leaving), the data encryption key has to be changed whenever a user joins or leaves the system. Such a change has to be made known to all the current users. The bandwidth used for such re-key messaging can be high when the user pool is large. We propose a distributed servers approach to minimize the overall system bandwidth (and complexity) by splitting the user pool into multiple groups each served by a (logical) server. After presenting an analytic model for the system based on a hierarchical key tree, we show that there is an optimal number of servers to achieve minimum system bandwidth. As the underlying user traffic fluctuates, we propose a simple dynamic scheme with low overhead where a physical server adaptively splits and merges its traffic into multiple groups each served by a logical server so as to minimize its total bandwidth. Our results show that a distributed servers approach is able to substantially reduce the total bandwidth required as compared with the traditional single-server approach, especially for those applications with a large user pool, short holding time, and relatively low bandwidth of a data stream, as in the Internet stock quote applications.
Coding efficiency and reliability in probe-based storage devices

High density probe-based storage devices use multiple, simultaneously accessed parallel channels for achieving high I/O data rates. This paper presents an analytical methodology for evaluating the performance of coding and interleaving schemes in such devices, when they are affected by burst errors. Markov processes are used to describe the burstiness of errors due to external disturbances and analytical formulas are provided to estimate the system reliability for various system parameters. Using this approach, the most appropriate system configuration, in terms of number of Reed-Solomon codewords, interleaving depth and coding rate can be determined for a given system reliability and storage efficiency.
Purism and Wilderness Campers

Abstract The characteristics of a sample of wilderness users were examined by administering the Purism Scale to 540 campers in three provincial parks in Ontario, Canada. Factor analysis revealed that the scale consists primarily of four interdependent factors that characterize sets of wilderness attitudes related to (a) size of and distance to wilderness areas, (b) a minimum level of human interference in wilderness, (c) natural ecosystems, and (d) man-made infrastructure (construction) in wilderness areas. The internal consistency of the Purism Scale was tested using three split-half techniques. Based on these tests, it appears that the scale is a sound measure of the degree of purism in attitudes toward wilderness.
Physiological Status and Prediction of Cardiovascular Fitness in Highly Trained Youth Soccer Athletes

This study evaluated the physiological status and assessed the validity of the 20-m shuttle run test (20 MST) in pre- dicting VO2 max values of these same athletes. Thirteen high- ly trained male soccer players (age 12.62 6 0.65 years) were tested for VO2 max, heart rate max, and maximum lactate via direct laboratory measurement (i.e., maximal treadmill test (TM)) and the 20 MST. Based on two 20 MST prediction equations, the cross-validation statistics were r 5 0.78, SE 3.82 for equation 1 and r 5 0.86, SE 52 1.39 for equation 2. No significant differences were found between the observed and predicted VO2 max values (p . 0.05). Specifically, the directly measured VO2 max 5 56.53 6 5.80, with predicted values of 58.68 6 3.22 and 55.14 6 3.89 for equations 1 and 2, respectively. There was a small but significant (p # 0.05) difference in HR max between the test protocols, with no significant difference for lactate values (TM lactate 5 6.07 6 1.40 and 20 MST lactate 5 6.26 6 1.92 mm/L). In conclusion, the 20 MST appears to be a valid method for predicting the cardiovascular fitness of youth soccer athletes.
Factors Associated With the Perception of Family Nursing Practice Among Mental Health Nurses in Taiwan

The aim of this study was to examine factors that influenced the perceptions of mental health nurses about involving families in their nursing practice. A sample of 175 Taiwanese mental health nurses who are employed in both inpatient and community settings completed structured questionnaires designed to measure empathy, attitudes about involving families in care, and perceptions of family nursing practice. Data were analyzed using descriptive statistics, Pearson’s product-moment correlation, t test, one-way ANOVA, and a hierarchical multiple regression analysis. Positive perceptions of family nursing practice were correlated with more years of clinical experience in mental health, empathy, supportive attitudes toward the importance of family nursing care, and personal experiences with family members with serious illness in need of professional care. These findings may assist in the development of effective educational programs designed to help nurses integrate family nursing knowledge and skills in the care of patients and families experiencing mental illness.