Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevención del estrés psicosocial del profesorado mediante el desarrollo de competencias emocionales: el programa P.E.C.E.R.A.

Los estresores psicosociales han aumentado enormemente en el seno de las sociedades desarrolladas. Son situaciones que no causan directamente la respuesta de estres, sino que se convierten en estresores a traves de la interpretacion cognitiva o del significado que la persona les asigna (LAZARUS, 2000). Entre ellos estan las situaciones de conflicto en la interaccion social con los problemas de convivencia derivados de ellas. En el momento actual, los problemas de convivencia en los centros educativos, especialmente en la etapa de la E.S. O. , estan alcanzando unas cifras preocupantes. La falta de una respuesta eficaz ante estos acontecimientos hace que aumenten las cifras de profesorado y alumnado afectados por fenomenos como el "burnout" o el "bullying". Esta situacion tiene una influencia tanto en la salud fisica y mental del profesorado (ansiedad, estres, depresion.), como en la falta motivacion, fracaso escolar y violencia entre iguales en el alumnado. Ante este estado de la cuestion, en el presente articulo nos centraremos en la prevencion del estres psicosocial en el profesorado mediante el desarrollo de competencias emocionales. Desde el modelo de consulta colaborativa, se hace una propuesta para la formacion del profesorado desde el programa P.E. C.E. R.A. (Programa Educativo de Conciencia Emocional, Regulacion y Afrontamiento), con el fin de desarrollar competencias emocionales en los docentes como paso previo para una adecuada intervencion en educacion emocional con su alumnado.
Pharmacokinetics and Antitumor Efficacy of XMT-1001, a Novel, Polymeric Topoisomerase I Inhibitor, in Mice Bearing HT-29 Human Colon Carcinoma Xenografts

Purpose: To evaluate the pharmacokinetics and tissue disposition of macromolecular camptothecin (CPT) drug conjugate, XMT-1001, and irinotecan (CPT-11) in mice bearing HT-29 xenograft tumors. Experimental Design: The antitumor efficacy of XMT-1001 was evaluated in the mouse HT-29 human colon carcinoma xenograft model. XMT-1001 was administered intravenously to female athymic nude (nu/nu) mice bearing established HT-29 xenograft tumors (n = 10) at 15, 30, and 60 mg CPT equivalents/kg on weekly or biweekly schedules. The tumor growth inhibition and tumor growth delay endpoints were used for efficacy evaluation. In the pharmacokinetic study, XMT-1001 was administered intravenously at a pharmacologically relevant dose of 60 mg CPT equivalents/kg × 1 via tail vein or an equimolar dose of CPT-11 at 100 mg/kg i.p. × 1. Mice (n = 3 per time point) were euthanized from 0.083 to 336 hours after XMT-1001 administration and from 0.083 to 24 hours after CPT-11. Plasma, tumor, and tissues were collected from all animals. A liquid chromatography–tandem mass spectrometry assay was used to measure XMT-1001, conjugate release products, CPT-20-O-(N-succinimido-glycinate; CPT-SI) and CPT-20-O-(N-succinamidoyl-glycinate; CPT-SA), and CPT. Results: After XMT-1001 administration, the majority of the plasma exposure is accounted for by conjugated CPT. XMT-1001 exhibited a prolonged exposure of conjugated drug, active conjugate primary release products, CPT-SI and CPT-SA, and active CPT, which was associated with greater antitumor response compared with CPT-11. Conclusions: XMT-1001 provides an extended systemic and tumor exposure of conjugated drug and shows improved antitumor effect compared with CPT-11. Clin Cancer Res; 18(9); 2591–602. ©2012 AACR.
The Feasibility of 350 &mgr;m Spatial Resolution Coronary Magnetic Resonance Angiography at 3 T in Humans

PurposeThe purposes of this study were to (1) develop a high-resolution 3-T magnetic resonance angiography (MRA) technique with an in-plane resolution approximate to that of multidetector coronary computed tomography (MDCT) and a voxel size of 0.35 × 0.35 × 1.5 mm3 and to (2) investigate the image quality of this technique in healthy participants and preliminarily in patients with known coronary artery disease (CAD). Materials and MethodsA 3-T coronary MRA technique optimized for an image acquisition voxel as small as 0.35 × 0.35 × 1.5 mm3 (high-resolution coronary MRA [HRC]) was implemented and the coronary arteries of 22 participants were imaged. These included 11 healthy participants (average age, 28.5 years; 5 men) and 11 participants with CAD (average age, 52.9 years; 5 women) as identified on MDCT. In addition, the 11 healthy participants were imaged using a method with a more common spatial resolution of 0.7 × 1 × 3 mm3 (regular-resolution coronary MRA [RRC]). Qualitative and quantitative comparisons were made between the 2 MRA techniques. ResultsNormal vessels and CAD lesions were successfully depicted at 350 × 350 &mgr;m2 in-plane resolution with adequate signal-to-noise ratio (SNR) and contrast-to-noise ratio. The CAD findings were consistent among MDCT and HRC. The HRC showed a 47% improvement in sharpness despite a reduction in SNR (by 72%) and in contrast-to-noise ratio (by 86%) compared with the regular-resolution coronary MRA. ConclusionThis study, as a first step toward substantial improvement in the resolution of coronary MRA, demonstrates the feasibility of obtaining at 3 T a spatial resolution that approximates that of MDCT. The acquisition in-plane pixel dimensions are as small as 350 × 350 &mgr;m2 with a 1.5-mm slice thickness. Although SNR is lower, the images have improved sharpness, resulting in image quality that allows qualitative identification of disease sites on MRA consistent with MDCT.
Attitudes towards family and marriage in time and context: using two British birth cohorts for comparison

With dramatic changes in family-related behaviours in the past 50 years, there has been an increasing awareness and acceptance of different family arrangements. Subsequently, measuring and studying people’s attitudes towards issues such as commitment to marriage, acceptance of alternative family forms, parental separation and gender roles has gained a lot of attention among those working in the fields of sociology, social psychology and demography. The majority of studies examining the relationship between family-related attitudes and behaviour have focused on either the selection or adaptation effects of attitudes, with fewer (particularly of those using British data) specifically addressing the possibility of both processes taking place. This study’s main goal is to address the latter using the data of two British cohorts born 12 years apart: the 1970 British Cohort Study (BCS) and the 1958 National Child Development Study (NCDS). The cohort’s attitudes are measured by a scale consisting of three items which relate to: marriage being a lifelong commitment, a divorce being easily obtainable these days and the acceptability of parental separation. This work adopts the perspective of value orientation and life course position which implies a recursive nature of attitudes and behaviour whereby behaviour is influenced by people’s values (the selection effect of attitudes) and these values, in turn, adjust following changes in people’s circumstances (the adaptation effect of attitudes). The availability of attitude statements at two time points for each cohort (at age 26 and 30 for BCS; at age 33 and 42 for NCDS) and rich partnership history data allows for such analyses to be carried out as the order of events can be established. Firstly, this research utilises bivariate and multivariate techniques to investigate the determinants of attitudes. Further, it implements regression analyses to explore the relationships between attitude scores and: a) transition to first marriage for non-cohabiting cohort members (BCS and NCDS); b) transition to first marriage of cohabiting cohort members (BCS) and c) dissolution of first marriage (NCDS). The main findings show some evidence of both the selection and adaptation effects of attitudes in relation to marital transitions for both cohorts, indicating the importance of attitudes in shaping people’s behaviour and at the same time showing the tendency of attitudes to change in line with an individual’s personal circumstances.
Tetracycline Regulator Expression Alters the Transcriptional Program of Mammalian Cells

Background Tetracycline regulated ectopic gene expression is a widely used tool to study gene function. However, the tetracycline regulator (tetR) itself has been reported to cause certain phenotypic changes in mammalian cells. We, therefore, asked whether human myeloid U937 cells expressing the tetR in an autoregulated manner would exhibit alterations in gene expression upon removal of tetracycline. Methodology/Principal Findings Microarray analyses revealed that 172 and 774 unique genes were significantly differentially expressed by at least 2- or 1.5-fold, respectively, when tetR expressing U937 cells were maintained in media with or without the antibiotic. Conclusions/Significance These alterations in gene expression are likely to contribute to the phenotypic consequences of tetR expression. In addition, they need to be taken into consideration when using the tetR system for the identification of target genes of transcription factors or other genes of interest.
Strength Recovery from Static and Dynamic Muscular Fatigue

Abstract Thirty university students were each given two types of local fatiguing exercise utilizing a spring-loaded hand ergograph. Six minutes of dynamic contractions at the rate of 30 per minute caused strength to decline from an initial value of 45.7 kg. to a steady-state value of 27.6 kg. The half-time (rate of decline) was 89 sec. The corresponding figures for two minutes of continuous static exercise were 46.9 kg. , 15.8 kg. , and 38 sec. Mathematical analysis of these fatigue curves confirmed the results of others. The progress of recovery was observed for 10 minutes. A two-component exponential equation accounted for the observed progressive return of strength. However, the rate parameters were quite different in the two curves; recovery was much faster and followed a different pattern after static exercise.
Passive multiple disjoint sources localization using TDOAs and GROAs in the presence of sensor location uncertainties

Passive source localization has been the focus of considerable research efforts due to its usefulness in various applications. This paper performs a fundamental investigation of whether the gain ratios of arrival (GROAs) can be utilized in conjunction with the time differences of arrival (TDOAs) to improve the multiple sources localization accuracy with erroneous sensor positions. It's an urgent need to find a closed-form solution with good localization accuracy for this challenging problem. This paper takes the advantage that the TDOAs and GROAs from different sources have the same sensor position displacements and proposes an estimator that jointly estimates the unknown sources and sensor positions. In order to establish an closed-form solution for multiple sources location estimates using GROAs and TDOAs, we use the idea of hypothesized source locations in the algorithm development to enable the formulation of pseudo-linear equations. The proposed algebraic solution does not require initialization and does not have divergence problem. Our conclusion is that the improvement from GROAs is obvious for multiple sources localization compared with methods only using TDOAs. Numerical simulations are included to support and corroborate the theoretical developments.
Brain fMRI processing and classification based on combination of PCA and SVM

fMRI is one of the fundamental tools for functional human brain research. However, fMRI data are often in a high dimensional feature space and suffer greatly from large and complex dataset. To relieve the curse of dimensionality in fMRI image, PCA combines with SVM to form a feature-based classification method in this work. PCA is employed to find a more compact and reasonable representation of the data by extracting features from each fMRI image. Then a linear kernel SVM classifier is trained on the selected features to detect different brain states. The advantage of incorporating PCA with SVM is twofold: Firstly, the computational burden on SVM classifier is reduced significantly. Secondly, a less complex classifier is well established. Experimental results show that the proposed method yields good performance. The correct rate of our hand-movement fMRI study with both healthy subjects and a tumor patient verified the stability and generalization capability of the method.
Vibration Suppression Motor Drive Control for Industrial Robot Using Notch Filter with Little Phase Error

This paper proposes a new generation method of position reference without the resonant frequency and phase error for industrial robots. It is important for the industrial robot to drive high speed and high accuracy. However, the vibration phenomenon is generated by the resonant frequency in such cases. Conventionally, the notch filter is used to suppress the vibration phenomenon. It is able to eliminate a particular frequency. However, it also has a disadvantage that the reference phase error is generated. Generating the phase error in the reference, the critical error is generated in the locus which the robot draws. Therefore, the accuracy of the robot is deteriorated by using the notch filter. The proposed method overcomes this problem by using the compensation gain. The compensation gain is used to calculate the reference phase error. The compensation of the reference phase error is performed by the feedforward. The simulation results and the experimental results show that the proposed method is superior to suppress the resonant frequency and improves the phase error.
Optimal and Approximate Methods for Detection of Uncoded Data with Carrier Phase Noise

Previous results in the literature have shown that derivation of the optimum \textit{maximum-likelihood} (ML) receiver for \textit{symbol-by-symbol} (SBS) detection of an uncoded data sequence based on all received signals in the presence of \textit{random phase noise} is an intractable problem. This is because it involves the computation of the conditional \textit{probability distribution function} (PDF) of the phase noise process. In this paper, we seek to minimize \textit{symbol error probability} (SEP), which is achieved by SBS detection of the sequence based on all received signals. We show that the ML detector for this problem can be formulated as a weighted sum of central moments of the conditional PDF of phase noise. Given that the central moments of the conditional PDF of phase noise can be estimated, this new optimal structure is tractable with respect to the previously known optimal ML receiver. Furthermore, based on the new receiver structure, we propose a simple approximate method for SBS detection and investigate its scope and applicability. Simulation results demonstrate that SEP performance close to optimality can be obtained through the proposed method for a wide range of phase noise variances and low \textit{signal-to-noise ratio} (SNR).
Aberrant Single Exon Skipping is not Altered by Age in Exons of NF1, RABAC1, AATF or PCGF2 in Human Blood Cells and Fibroblasts

In human pre-mRNA splicing, infrequent errors occur resulting in erroneous splice products as shown in a genome-wide approach. One characteristic subgroup consists of products lacking one cassette exon. The noise in the splicing process, represented by those misspliced products, can be increased by cold shock treatment or by inhibiting the nonsense mediated decay. Here, we investigated whether the splicing noise frequency increases with age in vivo in peripheral bloods cells or in vitro in cultured and aged fibroblasts from healthy donors. Splicing noise frequency was measured for four erroneously skipped NF1 exons and one exon of RABAC1, AATF and PCGF2 by RT-qPCR. Measurements were validated in cultured fibroblasts treated with cold shock or puromycin. Intragenic but not interpersonal differences were detected in splicing noise frequencies in vivo in peripheral blood cells of 11 healthy donors (15 y–85 y) and in in vitro senescent fibroblasts from three further donors. No correlation to the age of the donors was found in the splicing noise frequencies. Our data demonstrates that splicing error frequencies are not altered by age in peripheral blood cells or in vitro aged fibroblasts in the tested exons of the four investigated genes, indicating a high importance of correct splicing in these proliferating aged cells.
Young adults' willingness and intentions to use amphetamines: An application of the theory of reasoned action

A questionnaire study of 79 young Australian university students’ attitudes and norms for amphetamine use was conducted to test an alternative measure to intention in the theory of reasoned action (TRA). The study compared the usefulness of Gibbons and colleagues’ concept of behavioural willingness which, it is argued, captures a more reactive and social decision to perform a behaviour than behavioural intention, viewed as more deliberative in nature. Participants completed a questionnaire assessing their attitudes, subjective norms, intention and willingness to engage in amphetamine use in the following 2 weeks. The results provided support for the TRA with attitude and subjective norm significantly predicting intention. However, attitude and subjective norm accounted for a greater proportion of variance in the prediction of behavioural willingness. Overall, the findings provide some support for the notion that behavioural willingness is a more effective criterion than behavioural intention for tapping into the determinants of potentially less rational and more risky behaviours such as young adults’ illegal drug use.
Elevated urine levels of bufotenine in patients with autistic spectrum disorders and schizophrenia.

OBJECTIVE Previous studies have suggested that the endogeneous psychotomimetic molecule bufotenine (N-N-dimethyl-5-idroxytryptamine) may play a role in the pathogenesis of severe mental disorders. The potential association of bufotenine with the clinical features of autism and schizophrenia is not entirely understood. In this study, we measured urinary levels of bufotenine in subjects with autistic spectrum disorder (ASD), schizophrenia and healthy comparison subjects free of psychiatric symptoms. We also sought to assess whether urine concentrations of this molecule may be associated with the clinical characteristics of psychiatric patients. DESIGN Urine bufotenine levels were measured using a high-performance liquid chromatography-mass spectrometry (HPLC-MS) assay in young adults with severe ASD (n=15), patients with schizophrenia (n=15), and healthy control subjects (n=18). The Vineland Adaptive Behavior Scale was used to measure adaptive behaviors in ASD individuals. The Brief Psychiatric Rating Scale (BPRS) was used for patients with schizophrenia. RESULTS Urine bufotenine levels were significantly higher in ASD subjects (3.30 +/- 0.49 microg/L, p<0.05) and patients with schizophrenia (4.39 +/- 0.43 microg/L, p<0.001) compared with controls (1.53 +/- 0.30 microg/L). Among patients with ASD, there was a significant positive correlation between urine bufotenine and hyperactivity scores on the Vineland Adaptive Behavior Scale (r=0.479, p<0.05). No other associations were detected. CONCLUSIONS Our results indicate that elevated urine levels of the endogeneous psychotomimetic molecule bufotenine may play a role in ASD and schizophrenia, and can be correlated with hyperactivity scores in autism.
The response of correlated traits following cessation of fishery-induced selection

The application of evolutionary principles to the management of fisheries has gained considerable attention recently. Harvesting of fish may apply directional or disruptive selection to key life‐history traits, and evidence for fishery‐induced evolution is growing. The traits that are directly selected upon are often correlated (genetically or phenotypically) with a suite of interrelated physiological, behavioral, and morphological characters. A question that has received comparatively little attention is whether or not, after cessation of fishery‐induced selection, these correlated traits revert back to previous states. Here, we empirically examine this question. In experiments with the Atlantic silverside, Menidia menidia, we applied size‐selective culling for five generations and then maintained the lines a further five generations under random harvesting. We found that some traits do return to preharvesting levels (e.g., larval viability), some partially recover (e.g., egg volume, size‐at‐hatch), and others show no sign of change (e.g., food consumption rate, vertebral number). Such correlations among characters could, in theory, greatly accelerate or decelerate the recovery of fish populations. These results may explain why some fish stocks fail to recover after fishing pressure is relaxed.
The prevalence of Cryptococcus neoformans in various natural habitats.

Examination of 2098 samples of soil and organic debris from the southeastern United States utilizing the intravenous mouse inoculation technique resulted in the isolation of 128 strains of Cryptococcus neoformans. The incidence of the fungus in specimens from the various habitats sampled were as follows: pigeon habitats 50%, rabbit pens 14·7%, abandoned urban and rural houses 10·2%, animal barns and associated structures 7·4%, tobacco-curing barns 6·4% and poultry habitats 2·1%. Various unsheltered animal habitats, bird roosts and collections of organic debris did not reveal the presence of the fungus.When 95 of these isolates were serotyped employing a slide agglutination test, 91 were type A, 1 was type C and 3 were non-typeable. The significance of these findings as related to human infections is discussed.
Predicting Unknown Time Arguments based on Cross-Event Propagation

Many events in news articles don't include time arguments. This paper describes two methods, one based on rules and the other based on statistical learning, to predict the unknown time argument for an event by the propagation from its related events. The results are promising - the rule based approach was able to correctly predict 74% of the unknown event time arguments with 70% precision.
Efficient Skyline Computation over Ad-hoc Aggregations

Aggregation is among the core functionalities of OLAP systems. Frequently, such queries are issued in decision support systems to identify interesting groups of data. When more than one aggregation function is involved and the notion of interest is not clearly defined, skyline queries provide a robust mechanism to capture the potentially interesting points where (i) users do not need to specify a ranking function and (ii) the result is independent of the dimension scales. For providing better exploration functionalities in the OLAP system, in this paper, we propose to use skyline queries over aggregated data to identify the most interesting groups . Since the aggregation function has to be ad-hoc to cover a wide variety of user interests, the skyline over the aggregates has to be computed on the fly. Hence any algorithm to compute such a skyline must be fast and be able to progressively produce the result set with potential skyline groups being produced as early as possible. We explore a family of algorithms which try to consume only as many data records as are necessary to compute the skyline and design an optimal algorithm. We further refine the algorithm by taking into account systems issues such as disk behavior which are often ignored but have strong impact on real system performance. Experimental results validate the performance and progressive benefits of our algorithm.