Miracle-dz/UniFAR-FTUs huggingface dataset:
Brain activation pattern as assessed with multi-modal EEG analysis predict motor recovery among stroke patients with mild arm paresis who receive the Arm Ability Training.

PURPOSE Receiving the Arm Ability Training for three weeks improves motor function among stroke patients with mild arm paresis. There is, however, a considerable variability in recovery among patients receiving the Arm Ability Training. The study investigated whether intersubject differences in movement-related electric brain activity explain the variability in motor recovery. METHODS In a sample of 9 patients receiving the Arm Ability Training both motor performance using a standardised arm function test (TEMPA) and movement-related electric brain activity, i.e. slow cortical potentials (DC) as well as event-related desynchronisation of alpha (alpha-ERD) and beta activity (beta-ERD), were assessed before the Arm Ability Training was started. Stepwise multiple regression was used to establish the best predictive model for motor improvement scores (TEMPA difference from pre to post test three weeks later). RESULTS Stepwise multiple regression indicated that electric brain activity during movement preparation explained the variance of motor improvement scores completely. Further, electric brain activity during movement as well as baseline motor performance accounted each for 50% of the variance of motor improvement scores. CONCLUSIONS Activation of sensorimotor areas during movement preparation and deactivation of other cortical areas during movement execution seem to be factors that predict a favourable outcome after training.
Detecting Urban Dynamics with Taxi Trip Data for Evaluation and Optimizing of Spatial Planning:The Example of Xiamen City, China

: Commonly, it is very hard to examine underlying urban dynamics due to rapid spatial expansion and land use variations. In this paper, the origin-destination (OD) data extracted from taxi trip data collected in Xiamen, China, covering 30 days was utilized to detect the underlying dynamics of Xiamen City. Specifically, we discretized the study area into 400m*400m grids so that the number of originating points and destination points of the taxi trips could be counted separately within each single grid. Then, heat maps of the taxi mobility were made to achieve a general understanding of urban dynamics. Secondly, we took advantage of the concept of complex networks to analyze the daily taxi trip data. Using a method of community detection, we divided the study area into six main sub-regions called functional self-sufficient zones (FSZs) in which spatial associations are tight and dense. The features of these FSZs helped us to gain a deeper understanding of urban dynamics. Finally, based on this understanding, we further evaluated and optimized the urban spatial planning of Xiamen. Balancing land use allocation was suggested to enhance the multi-centric structure and reduce congestion. This study provides a relevant contribution by exploring the potential of applying taxi trip data to identify urban dynamics revelations and urban planning optimization solutions.
Department of Information and Service Economy Impact of Cloud Computing on Business Process Outsourcing Case : Accounting in Small and Medium-sized Enterprises

Aalto University, P.O. Box 11000, FI-00076 Aalto www.aalto. fi Author Aleksandre Asatiani Name of the doctoral dissertation Impact of Cloud Computing on Business Process Outsourcing Publisher School of Business Unit Department of Information and Service Economy Series Aalto University publication series DOCTORAL DISSERTATIONS 154/2016 Field of research Information Systems Science Date of the defence 30 September 2016
Applicability of the transmission-reflection method for broadband characterization of seawater permittivity in a semi-open coaxial test cell

We validate applicability of the known transmission-reflection (T/R) method to measuring complex permittivity of seawater in broadband frequency range. We consider a liquid sample that partly fills space of a coaxial test cell operating in vertical position. The cell is plugged with a single dielectric bead at the bottom and thus has a semi-open, versatile design. We develop transfer matrix formulae for de-embedding the sample from effects of the bead and the airline sections so as best fulfill assumptions of the T/R method. The de-embedded scattering parameters of the sample let us analyze effects of an asymmetry in the sample's reflection coefficients due to a meniscus formed at the top of the sample. Experimental results, obtained for seawater in a 7 mm coaxial-line fixture, evidence that the meniscus effects are negligible below 5 GHz. The measured permittivity of the seawater agrees very well with the data published elsewhere.
User Satisfaction with Information Seeking on the Internet

The research described in this article focused on how satisfied Australian academics are when they use the Internet to search for information. The significant methodological outcome of the research was its validation of magnitude estimates of user satisfaction with information seeking on the Internet. Testing the validity and reliability of magnitude estimation as a technique for gathering and analyzing interval data on satisfaction with information seeking was key to the investigation. Data for user satisfaction were then associated with end-user characteristics like training, frequency of use, and expectation of success. The study found that Australian academics generally have a high expectation of success when they engage in information seeking on the Internet, and are satisfied with the process regardless of how frequently they use the network or whether or not they have received formal training. © 1998 John Wiley & Sons, Inc.
Parameterization of Mixed Layer Eddies. II: Prognosis and Impact

Fox-Kemper et al. (2007a) propose a parameterization for restratification by mixed layer eddies that develop from baroclinic instabilities of ocean fronts. The parameterization is cast an overturning streamfunction that is proportional to the product of horizontal buoyancy gradient, mixed layer depth, and inertial period. The parameterization has remarkable skill for an extremely wide range of ML depths, rotation rates, vertical and horizontal stratifications. In this paper a coarse resolution prognostic model of the parameterization is compared with submesoscale mixed layer eddy resolving simulations. The parameterization proves accurate in predicting changes to the buoyancy. The climate implications of the proposed parameterization are estimated by applying the restratification scaling to observations: the mixed layer depth is estimated from climatology, and the buoyancy gradients from satellite altimetry. The vertical fluxes are comparable to monthly mean air-sea fluxes in large areas of the ocean and suggest that restratification by mixed layer eddies is a leading order process in the upper ocean. Critical regions for ocean-atmosphere interaction, such as deep, intermediate, and mode water formation sites, are particularly affected.
P63 gene mutations and human developmental syndromes.

The P63 gene is a recently discovered member of the p53 family. While P53 is ubiquitously expressed, p63 is expressed specifically in embryonic ectoderm and in the basal regenerative layers of epithelial tissues in the adult. Complete abrogation of P63 gene function in an animal model points to the relevance of P63 for the proper development of ectodermally derived tissues. The p63 knockout mouse dies at birth and has truncation of the limbs, as well as absence of epidermis, prostate, breast, and urothelial tissues, apparently reflecting ectodermal stem cell loss. A number of dominant human syndromes have been mapped to chromosome 3q27 and ultimately to mutations in the p63 gene. These syndromes have abnormal limb development and/or ectodermal dysplasia and include ectrodactyly, ectodermal dysplasia, clefting syndrome; ankyloblepharon, ectodermal dysplasia, clefting syndrome; acro-dermato-ungual-lacrimal-tooth syndrome; limb-mammary syndrome; as well as nonsyndromic split hand/foot malformation. The pattern of heterozygous mutations is distinct for each of these syndromes. Consistent with this syndrome-specific mutational pattern, the functional consequences of mutations on the p63 proteins also vary, invoking dominant-negative and gain-of-function mechanisms rather than a simple loss of function.
Hydroxyapatite and Fluorapatite Coatings for Fixation of Weight Loaded Implants

Survivor analysis of total hip replacement recently has shown disappointing results in younger patients. To improve this, ceramic coatings have been applied to prostheses for cementless use. A new fluorine containing coating, fluorapatite, has been shown to increase bone ingrowth compared with hydroxyapatite in unloaded models. In a weight loaded model, the effects of hydroxyapatite and fluorapatite coated implants on implant fixation and bone ingrowth were evaluated. Eight hydroxyapatite and fluorapatite coated implants with porous surface were inserted into the medial femoral condyles of 8 mature dogs in a paired design. The implants initially were surrounded by a gap communicating with the joint space and were loaded during each gait cycle. After 25 weeks, no differences in pushout data or bone ingrowth between hydroxyapatite and fluorapatite coated implants were found. An important finding was the absence of foreign body reaction in the bone. Neither hydroxyapatite nor fluorapatite coatings delaminated during implantation or as a result of the pushout test. Bone repair activity remained in the initial gap zone, but most of the bone was of the lamellar type. No difference in bone remodeling between the hydroxyapatite and fluorapatite coated implants was found in the initial gap zone. Microprobe analysis showed no increase in fluorine content around the fluorapatite coated implants. The hydroxyapatite and fluorapatite coatings seem efficacious after a 25-week implantation period under weight loaded conditions.
A Novel Type of Deubiquitinating Enzyme*

A previous report from this laboratory described two novel proteins that have sequence similarity to A20, a negative regulator of NF-κB (Evans, P. C., Taylor, E. R., Coadwell, J., Heyninck, K., Beyaert, R., and Kilshaw, P. J. (2001) Biochem. J. 357, 617–623). One of these molecules, cellular zinc finger anti-NF-κB (Cezanne), a 100-kDa cytoplasmic protein, also suppressed NF-κB. Here we demonstrate that Cezanne is a novel deubiquitinating enzyme, distinct from the two known families of deubiquitinases, Types I and II. We show that Cezanne contains an N-terminal catalytic domain that belongs to the recently discovered ovarian tumor protein (OTU) superfamily, a group of proteins displaying structural similarity to cysteine proteases but having no previously described function. Recombinant Cezanne cleaved ubiquitin monomers from linear or branched synthetic ubiquitin chains and from ubiquitinated proteins. Mutation of a conserved cysteine residue in the catalytic site of the proteolytic domain caused Cezanne to co-precipitate polyubiquitinated cellular proteins. We also provide evidence for an additional ubiquitin binding site in the C-terminal part of the molecule. Our data provide the first demonstration of functional activity among OTU proteins.
INHIBITION OF SPERM-ZONA PELLUCIDA BINDING BY A 55 kDa PIG SPERM PROTEIN IN VITRO

This study was conducted to evaluate the role of a 55 kDa pig sperm protein on the oocyte-sperm binding process, and its location in situ. For this purpose, in vitro matured oocytes were incubated with isolated and purified protein, and incubated with capacitated spermatozoa. In addition, capacitated sperm were incubated with anti-55 kDa antiserum and later with mature oocytes. Immunolocalization assays were performed using non-capacitated, capacitated and acrosome reacted sperm, which were incubated independently with anti-55 kDa protein antibodies and analyzed under fluorescence light microscopy. The 55 kDa protein concentrations correlated negatively with the amounts of sperm bound to the zona pellucida (ZP); the presence of the anti-55 kDa protein totally inhibited this binding. The immunolocalization assays revealed that fluorescence was located preferentially at the apical edge of the head in capacitated sperm, but not in acrosome reacted sperm. It would appear that the 55 kDa protein binds specifically to the oocyte ZP, and that it may be responsible for primary gamete binding during fertilization.
Using biologically inspired computing to effectively improve prediction models

The complexity of certain problems causes that classical methods for finding exact solutions have some limitations. In this paper we propose an incremental heterogeneous ensemble model for time series prediction where biologically inspired algorithms offer a suitable alternative. Ensemble learning techniques are advantageously used for improving performance of various prediction methods. The quality of this kind of machine learning approaches depends on proper combination of used methods. The influence of each of the used method can change on the fly and is determined by proper choice of its weights. Finding optimal weights in prediction methods represents typical optimization problem with objective function reflecting error minimization, where biologically inspired algorithms can be used. In the proposed paper, we study several biologically inspired algorithms in the process of weights optimization. We investigate and compare ensembles using base models and ensembles op- timized by biologically inspired algorithms. We demonstrate that the ensemble learning prediction models optimized by biolog- ically inspired algorithms outperformed the base prediction methods. We present performance and accuracy results of proposed ensemble models that were evaluated on power load datasets with concept drifts.
Modern Trends and Practices of E-Marketing: An Overview

With the unprecedented growth of technology in global world, internet plays a paramount role in all the major areas of our life and industries. With-in few clicks we can explore ample information which will help in conceptualizing many tasks in nanoseconds and realizing this power of internet, marketing is not far behind to use it as a driving channel to reach the global territory. eMarketing also known as digital marketing comprises the usage of virtual digital space with a scope of interaction, this digital space is been used by the marketer to promote and sell the products and services. This internet based marketing played a pivotal role to uplift the different economic sectors with special emphasize on marketing. Considering this is a cost effective, fast and flexible way to reach the audience of global Diasporas, e-marketing bring substantial business gains. However e-marketing has its own sets of limitations that include more of tech touch instead of personnel touch, ensuring the safety and security with aspect of privacy infringement. The paper starts with defining the concept, origin, how different emarketing is from traditional marketing, 7 C’s of e-marketing, different strategies of e-marketing the advantages, limitations, its future and conclusion.
Long-Term Efficacy and Safety of Twice-Daily Saquinavir Soft Gelatin Capsules (SGC), with or without Nelfinavir, and Three Times Daily Saquinavir-SGC, in Triple Combination Therapy for HIV Infection: 100-Week Follow-Up

Objectives To evaluate the long-term efficacy and safety of saquinavir soft gelatin capsules (SQV-SGC) (Fortovase®) in twice-daily, with or without nelfinavir (NFV), and three-times-daily regimens. This was an extension of a 48-week study, with follow-up to 100 weeks. Design Patients were randomized to one of three treatment arms: arm A, SQV-SGC 1200 mg three times daily plus two nucleoside reverse transcriptase inhibitors (NRTIs); arm B, SQV-SGC 1600 mg twice daily plus two NRTIs; or arm C, SQV-SGC 1200 mg twice daily plus NFV 1250 mg twice daily plus one NRTI. At week 48, patients could either withdraw or continue in the study to the common study closure date. Antiretroviral activity was assessed by changes in HIV-1 RNA values and CD4 cell counts from 48 weeks until 100 weeks. Results In the modified intention-to-treat population, the proportion of patients with HIV-1 RNA values <400 copies/ml was statistically different between arms A and C (49 vs 28%, P=0.017), and arms B and C (48 vs 28%, P=0.027). Continued suppression of HIV-1 replication (HIV-1 RNA <400 copies/ml) was observed through 100 weeks in 83% (30/36), 73% (29/40) and 62% (16/26) of patients in treatment arms A, B and C, respectively, in the on-treatment (OT) population. At 100 weeks, sustained increases were achieved in mean CD4 cell counts of +361, +273 and +309 cells/mm3, respectively (OT population). No additional adverse events or increase in the proportion of patients reporting adverse events were observed from 48 weeks to 100 weeks. Conclusions This study demonstrates the long-term efficacy and safety of SQV-SGC twice daily, with or without NFV, and three times daily, in triple combination therapy for HIV-1-infected patients. However, the evidence suggests that long-term treatment with SQV-SGC plus NFV may be less acceptable to patients.
Antimicrobial Stewardship and the Allergist: Reclaiming our Antibiotic Armamentarium.

She served as the President of the Maryland Branch of ASM and on more than a dozen committees for the national organization. For her outstanding service for advancing the field of microbiology and for her service to ASM, Dr Charache received one of the most prestigious awards to be bestowed upon a clinical microbiologist, the bioMérieux Sonnenwirth Award for Excellence in Clinical Microbiology. Dr Pat’s commitment extended globally. In service to the National Academy of Sciences as a member of the Board on Science and Technology, she provided microbiology consultative services and mentorship to budding microbiologists and physicians in >30 countries. Her most recent international activities involved efforts to curb tuberculosis. Dr Charache is survived by her husband, Samuel Charache, MD, Professor Emeritus of Pathology and Medicine of the Johns Hopkins University School of Medicine; their daughter, Barbara Charache Coleman, RN, research nurse at the Bayview Medical Center; 4 grandchildren (Debra, David, Dean, and Daniel); her sister, Jane Pier; and her brother, Dr Robert Connamacher.
OPTIMAL CONTROLLABILITY FOR SCALAR CONSERVATION LAWS WITH CONVEX FLUX

The optimal control problem for Burgers equation was first considered by Castro, Palacios and Zuazua. They proved the existence of a solution and proposed a numerical scheme to capture an optimal solution via the method of "alternate decent direction". In this paper, we introduce a new strategy for the optimal control problem for scalar conservation laws with convex flux. We propose a new cost function and by the Lax–Oleinik explicit formula for entropy solutions, the nonlinear problem is converted to a linear problem. Exploiting this property, we prove the existence of an optimal solution and, by a backward construction, we give an algorithm to capture an optimal solution.
Prototyping Social Interactions with DIY Animatronic Creatures

For some time now, robotics research has shifted its attention from robots that function within their own predefined space to robots that coexist with humans in the human's natural habitats. This evolution has not only driven interest in robot safety and compliance, it has also resulted in the subdomain of Social Robotics, which is concerned with natural interaction between robots and humans. In this studio, we will offer participants the chance to create their own animatronic creature using modular building blocks derived from Ono, our low-cost Do-It-Yourself social robot. In the first part, we will help participants to conceptualize a context and scenario for their social robot. Then, using craft materials (e.g. cardboard, glue, fabrics, foam, etc.) in combination with custom connectors and our animatronic modules, participants will build the physical embodiment of their creature. Finally, they are brought to life by connecting the modules to our electronics platform (Raspberry PI), which is then programmed using an easy to use library.
A master regulator for biofilm formation by Bacillus subtilis

Wild strains of Bacillus subtilis are capable of forming architecturally complex communities of cells known as biofilms. Critical to biofilm formation is the eps operon, which is believed to be responsible for the biosynthesis of an exopolysaccharide that binds chains of cells together in bundles. We report that transcription of eps is under the negative regulation of SinR, a repressor that was found to bind to multiple sites in the regulatory region of the operon. Mutations in sinR bypassed the requirement in biofilm formation of two genes of unknown function, ylbF and ymcA, and sinI, which is known to encode an antagonist of SinR. We propose that these genes are members of a pathway that is responsible for counteracting SinR‐mediated repression. We further propose that SinR is a master regulator that governs the transition between a planktonic state in which the bacteria swim as single cells in liquid or swarm in small groups over surfaces, and a sessile state in which the bacteria adhere to each other to form bundled chains and assemble into multicellular communities.
Preliminary Evaluation of the Potential Prognostic Value of Serum Levels of Immunoglobulins (IgA, IgM, IgG, IgE) in Patients with Gastric Cancer

Sixty patients with advanced gastric carcinoma who refused to receive cytotoxic chemotherapy were examined for serum immunoglobulin levels (IgG, IgM, IgA, IgE). Three samples were obtained every two months thereafter. The group of patients who had above-normal values of one or more of the examined immunoglobulins had a longer survival than the other (p<0.024). Immunoglobulin values were independent of the Helicobacter pylori antibody titer and of acute phase reactants. It is concluded that survival potentially correlates with serum immunoglobulin levels. Further studies including larger numbers of patients and correlating serum immunoglobulin levels with specific clinical parameters are needed to establish the prognostic role of serum immunoglobulins in patients with gastric carcinoma.
Brain Tumor Texture Analysis - Using Wavelets and Fractals

Brain tumor segmentation is quite popular area of research but detection of its surface texture is challenging for researchers. Normally, MRI datasets have very low resolution. This paper utilizes image enhancement technique based on wavelet. It is used to scale the low resolution image to a suitable resolution without loss. Secondly the proposed method is focused on implementation of a trained classifier using features: fractal dimension, fractal area, and wavelet average to classify type of texture present in brain tumor.
A Perspective on Leading and Managing Organizational Change

Organizational change poses significant challenges. Change itself is changing; evolving in ways that present new rules, new strategies for winning, and more and more dynamic complexity. This paper presents the principal drivers of change as stand-alone entities and later discusses their interaction effects. Organizational Life Cycle Change, types of change, capacity for learning, and the common causes of change failures are explored to establish an understanding of the proclaimed enormity of the change-failure issue and our difficulty in quantifying it. The paper concludes with suggestions that will help organizational change agents improve their success rates.