Miracle-dz/UniFAR-FTUs huggingface dataset:
Identifying barriers to participation in cardiac prevention and rehabilitation programmes via decision tree analysis: establishing targets for remedial interventions

Background Participation rates of patients with acute coronary syndrome (ACS) in efficacious cardiac prevention and rehabilitation programmes (CPRPs) are low, particularly in ethnic minorities. Few studies have evaluated the full array of potential barriers to participation in a multiethnic cohort with identical insurance coverage. Objective To assess the hierarchy of multiple barriers (ie, sociodemographic, systemic, illness related, psychological and cultural) to participation in CPRP of Jewish and Arab patients served by a regional hospital in Israel. Methods Patients with ACS (N=420) were interviewed during hospitalisation about potential barriers and subsequently about participation in CPRP. Decision tree analysis determined, hierarchically, the best predictors of participation in CPRP. Results Ethnicity was the salient predictor of participation in CPRP (61.1% (95% CI 55.6% to 66.5%) of Jewish patients versus 17.2% (95% CI 11.2% to 24.9%) of Arab patients). Among Jewish patients the dominant determinant was a recommendation for CPRP in the hospital discharge letter (32.5% (95% CI 23.1% to 43.1%) vs 71.9% (95% CI 65.8% to 77.6%) participation without and with a recommendation, respectively). Other major hierarchical determinants included age, discharge diagnosis, socioeconomic position and perceived benefits of exercise. Among Arab patients, anxiety was the main predictor (5.5% (95% CI 1.1% to 14.1%) vs 27.9% (95% CI 17.7% to 40.0%) participation among those with high vs lower anxiety levels). Additional contributors were a predischarge visit to the rehabilitation centre (familiarisation) and car ownership (access). Conclusions Utilisation of decision tree analysis enables us to identify the key barriers to participation in CPRP in an ethnic-specific mode. Interventions to improve participation can then be designed to address each group's specific barriers.
A compact microstrip-fed slot antenna with a dual-band notched function for WiMAX Operation

The WiMAX is an emerging wireless communication technology which can provide high speed connectivity for the internet. In terms of transmission distance, data transmission speed, and the construction cost of network are good broadband wireless access solution. This network technology is without having the traditional PSTN (Public Switched Telephone Network) and cable. But it can provide consumers used wireless technology to connecting the internet and to transmit or receive the required information in the city or suburb. In addition, WiMAX is a backhaul of WLAN, when the products have WiMAX technology, users can use the WLAN connectivity within the hotspot. In recent years, many studies of the CPW- fed printed slot antennas [1–2, 6], and microstrip-line fed printed slot antennas [3–5] have been proposed. In particular printed wide-slot antennas are adopted because its characteristic is conductive to enhance the bandwidth. The antenna proposed in [1] is a CPW-fed square slot antenna, which uses a widened tuning stub to enhance the bandwidth, but its size is large and the bandwidth is not wide enough to support most wireless applications. In [3], the designed antenna uses a rectangular slot with a triangular slot on the bottom to achieve broadband. In [4–6], these proposed antennas used different shapes strips and inserting the slot, the strips can reject the frequency bands of unwanted.
On the Fourth Diadema Species (Diadema-sp) from Japan

Four long-spined sea urchin species in the genus Diadema are known to occur around the Japanese Archipelago. Three species (D. savignyi, D. setosum, and D. paucispinum) are widely distributed in the Indo-Pacific Ocean. The fourth species was detected by DNA analysis among samples originally collected as D. savignyi or D. setosum in Japan and the Marshall Islands and tentatively designated as Diadema -sp, remaining an undescribed species. We analyzed nucleotide sequences of the cytochrome oxidase I (COI) gene in the “D. savignyi-like” samples, and found all 17 individuals collected in the mainland of Japan (Sagami Bay and Kyushu) to be Diadema-sp, but all nine in the Ryukyu Archipelago (Okinawa and Ishigaki Islands) to be D. savignyi, with large nucleotide sequence difference between them (11.0%±1.7 SE). Diadema-sp and D. savignyi shared Y-shaped blue lines of iridophores along the interambulacrals, but individuals of Diadema-sp typically exhibited a conspicuous white streak at the fork of the Y-shaped blue iridophore lines, while this feature was absent in D. savignyi. Also, the central axis of the Y-shaped blue lines of iridophores was approximately twice as long as the V-component in D. savignyi whereas it was of similar length in Diadema-sp. Two parallel lines were observed to constitute the central axis of the Y-shaped blue lines in both species, but these were considerably narrower in Diadema-sp. Despite marked morphological and genetic differences, it appears that Diadema-sp has been mis-identified as D. savignyi for more than half a century.
Passive microwave‐derived snow melt regions on the Greenland Ice Sheet

By comparing data from the Special Sensor Microwave Imager (SSM/I) to field data, a melt threshold of the cross-polarized gradient ratio (XPGR), which is a normalized difference between the 19 GHz horizontally-polarized and 37 GHz vertically polarized brightness temperatures, is determined. This threshold, XPGR = −0.025, is used to classify dry and wet snow. The annual areal extent of melt is mapped for the years 1988 through 1991, and inter-annual variations of melt extent are examined. The results show that the melt extent varied from a low of 38.3% of the ice sheet (1990) to a high of 41.7% (1991) during the years 1988–1991.
Multidrug and optimal heart failure therapy prescribing in older general practice populations: a clinical data linkage study

Objective To investigate multidrug therapy in the cardiovascular disease (CVD) population and whether it was associated with suboptimal drug prescribing in heart failure (HF). Design A population-based cross-sectional clinical data linkage study. Setting The clinical database populations were registered with three general practices in North Staffordshire that are part of a research network. Participants 3155 patients aged 50 years and over were selected on the basis of a CVD-related prescription and a CVD consultation code applied to their electronic medical record in a 2-year time period. All available diagnostic data were linked to all drugs prescribed data during this time period. Two study groups were: (1) HF and (2) non-HF CVD (reference group). Exposure A standard drug formulary system was used to define four multidrug count categories based on the number of different British National Formulary drug chapters prescribed at the same time. Primary and secondary outcome measures Optimal HF therapy was defined as the prescribing of ACE inhibitor (ACEi) or a combination of ACEi and β-blocker in the 2-year time window. An additional three specific CVD drug categories that are indicated in HF were also measured. Results The HF group, compared with the reference group, had higher non-CVD multidrug therapy (26% with 7 or more counts compared with 14% in the non-HF CVD reference group). For the first-choice optimal drug treatment for HF with ACEi (64%) or ACEi and β-blocker combined therapy (23%), the multidrug-adjusted associations between the HF group and the reference group were OR 3.89; 95% CI 2.8 to 5.5 and 1.99; 1.4 to 2.9, respectively. These estimates were not influenced by adjustment for sociodemographic factors and multidrug counts. Conclusions Multidrug therapy prescribing is much higher in the HF group than in a comparable CVD group but did not influence optimal drug prescribing.
The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas

Purpose: mTOR pathway hyperactivation occurs in approximately 90% of glioblastomas, but the allosteric mTOR inhibitor rapamycin has failed in the clinic. Here, we examine the efficacy of the newly discovered ATP-competitive mTOR kinase inhibitors CC214-1 and CC214-2 in glioblastoma, identifying molecular determinants of response and mechanisms of resistance, and develop a pharmacologic strategy to overcome it. Experimental Design: We conducted in vitro and in vivo studies in glioblastoma cell lines and an intracranial model to: determine the potential efficacy of the recently reported mTOR kinase inhibitors CC214-1 (in vitro use) and CC214-2 (in vivo use) at inhibiting rapamycin-resistant signaling and blocking glioblastoma growth and a novel single-cell technology—DNA Encoded Antibody Libraries—was used to identify mechanisms of resistance. Results: Here, we show that CC214-1 and CC214-2 suppress rapamycin-resistant mTORC1 signaling, block mTORC2 signaling, and significantly inhibit the growth of glioblastomas in vitro and in vivo. EGFRvIII expression and PTEN loss enhance sensitivity to CC214 compounds, consistent with enhanced efficacy in strongly mTOR-activated tumors. Importantly, CC214 compounds potently induce autophagy, preventing tumor cell death. Genetic or pharmacologic inhibition of autophagy greatly sensitizes glioblastoma cells and orthotopic xenografts to CC214-1- and CC214-2–induced cell death. Conclusions: These results identify CC214-1 and CC214-2 as potentially efficacious mTOR kinase inhibitors in glioblastoma, and suggest a strategy for identifying patients most likely to benefit from mTOR inhibition. In addition, this study also shows a central role for autophagy in preventing mTOR-kinase inhibitor-mediated tumor cell death, and suggests a pharmacologic strategy for overcoming it. Clin Cancer Res; 19(20); 5722–32. ©2013 AACR.
Ligand Aligning Method for Molecular Docking: Alignment of Property-Weighted Vectors

To reduce searching effort in conformational space of ligand docking positions, we propose an algorithm that generates initial binding positions of the ligand in a target protein, based on the property-weighted vector (P-weiV), the three-dimensional orthogonal vector determined by the molecular property of hydration-free energy density. The alignment of individual P-weiVs calculated separately for the ligand and the protein gives the initial orientation of a given ligand conformation relative to an active site; these initial orientations are then ranked by simple energy functions, including solvation. Because we are using three-dimensional orthogonal vectors to be aligned, only four orientations of ligand positions are possible for each ligand conformation, which reduces the search space dramatically. We found that the performance of P-weiV compared favorably to the use of principle moment of inertia (PMI) as implemented in LigandFit when we tested the abilities of the two approaches to correctly predict 205 protein-ligand complex data sets from the PDBBind database. P-weiV correctly predicted the alignment of ligands (within rmsd of 2.5 Å) with 57.6% reliability (118/205) for the top 10 ranked conformations and with 74.1% reliability (152/205) for the top 50 ranked conformations of Catalyst-generated conformers, as compared to 22.9% (47/205) and 31.2% (64/205), respectively, in the case of PMI with the same conformer set.
Medicaid Drug Utilization Review: A Critical Appraisal

During the 1980s, prescription drug costs increased faster than other components of the Medicaid budget. In 1980, total vendor payments for prescription drugs were $1.3 billion, or 5.7 percent of all Medicaid expenditures. By 1990, prescription drug expenditures had risen to $4.4 billion, or 6.3 percent of the Medicaid budget (National Pharmaceutical Council 1991). Faced with this expenditure pattern and increasing federal deficits, Congress included a provision in the Omni-
Game theoretic distributed dynamic resource allocation with interference avoidance in cognitive femtocell networks

This paper investigates new decentralized dynamic resource allocation scheme which exploits game theoretic regret-matching procedure to enhance the spectrum efficiency for cognitive femtocell networks. In order to ensure spectrum usage, we develop a new resource allocation scheme with joint overlay and underlay strategy to increase frequency reuse factor among cognitive femtocell networks. The proposed scheme can avoid interference to macrocell and the other femtocell user equipments; furthermore, the number of iterations required is less than the original regret-matching scheme, and it has been proved that at least one of correlated equilibrium exists in proposed algorithm. Computer simulations are presented to verify the proposed scheme which is effective for resource allocation. The proposed scheme is comparable to the performance of exhaustive search scheme and outperforms the original regret-matching scheme.
Generation of a debris avalanche and violent pyroclastic density current on 26 December (Boxing Day) 1997 at Soufrière Hills Volcano, Montserrat

Abstract Growth of an andesitic lava dome at Soufriere Hills Volcano, Montserrat, beginning in November 1995, caused instability of a hydrothermally altered flank of the volcano. Catastrophic failure occurred on 26 December 1997, 14 months after the instability was first recognized. Two months before failure a dome lobe had extruded over the unstable area and by 25 December 1997 this had a volume of 113 x 106m3. At 03:01 (local time) the flank rocks and some dome talus failed and generated a debris avalanche (volume 46 x 106 m3). Between 35 and 45 x 106 m3 of the dome then collapsed, generating a violent pyroclastic density current that devastated 10 km2 of southern Montserrat. The failure of the flank and dome formed two adjacent bowl-shaped collapse depressions. The most intense activity lasted about 11.6 minutes. The hummocky debris avalanche deposit is composed of a mixture of domains of heterolithic breccia. The pyroclastic density current had an estimated peak velocity of 80-90 ms-1, and minimum flux of 108 kgs1. The current was largely erosional on land with most deposition out at sea. Destructive effects included removal of houses, trees and large vehicles, and formation of a scoured surface blackened by a thin (3-4 mm) layer of tar. Two discrete depositional units formed from the pyroclastic density current, each with a lower coarse-grained layer and an upper fine-grained stratified layer. These deposits are overlain by an ashfall layer related to buoyant lofting of the current. Flank failure is attributed to loading of hydrothermally weakened rocks by the dome. The generation of the pyroclastic density current is attributed to failure and explosive disintegration of the dome, involving release and violent expansion of gases initially at high pore pressures.
Constructing the Olympic Dream: A Future Perfect Strategy of Project Management

In this paper we investigate a uniquely complex organizational context--that of the fast-tracked large-scale project management of a significant piece of Sydney 2000 Olympic infrastructure, which we researched in terms of its management through the "future perfect. " In a grounded analysis we resolved to track how the future perfect developed in the life of one large, complex project whose uniqueness meant that it was unable to be strategically planned in advance. We tracked the use of what we term "future perfect strategy" through analysis of data collected both in leadership meetings of the directing agency, "PALT"--Project Alliance Leadership Team--as well as in individual interviews that we conducted in and around the project, and through analysis of media coverage. Overall, the project was a success, but some problems arose along the way to completion. Largely, these were focused on issues of social rather than technical construction--something even the most strategic of plans cannot account for. As well as identifying some of the specific mechanisms for encouraging future perfect strategy that were used in the project, including encouraging "strange conversations," "playing end games," "workshopping," and "projecting feelings, concerns and issues," we also suggest some ways that the social construction issues might be handled in the future.
Phase noise reduction in scanning oscillator arrays

A five element coupled voltage controlled oscillator array using injection locking technique to obtain low phase noise combined power output is described. Spectrum measurement shows that a great improvement on the spectrum purity of the combined output of the array has been achieved. Measured radiation patterns indicate that phase-shifterless beam scanning technique works properly when a single element is phase-locked to a low phase noise source. <<ETX>>
Removal of the Invasive Shrub, Lonicera Maackii, from Riparian Forests Influences Headwater Stream Biota and Ecosystem Function

Riparian forests and streams are interlinked by cross‐system subsidies and alterations of the terrestrial environment can have substantial effects on aquatic biota and ecosystem function. In the Midwestern USA, the exotic shrub Lonicera maackii (Amur honeysuckle) has successfully invaded many riparian habitats, creating near‐monocultures in some locations. This terrestrial invasion has strong potential to modify cross‐system subsidies and impact stream ecosystems. We removed L. maackii from a riparian forest to assess impacts on the aquatic environment. In August 2010, removal occurred along a 150 m stream reach, 10 m downstream of a non‐removal reach, before natural leaf senescence. Over 74 days, in‐stream leaf litter [organic matter (OM)] was collected weekly from plots located in riffles (five/reach). Benthic algal biomass, above stream canopy cover, and macroinvertebrate density were measured for 18 months. L. maackii removal was associated with decreased canopy cover and a significant increase in total in‐stream leaf OM in early autumn (P < 0.05). Removal also differentially influenced the timing and abundance of specific leaf litter genera within the stream (P < 0.05). Macroinvertebrate density was significantly higher in the removal reach, especially during autumn 1 year after removal (P = 0.0294). In both reaches, macroinvertebrate density peaks lagged behind benthic algal biomass peaks. In summary, the removal of an invasive riparian shrub influenced the timing, deposition, quality and abundance of leaf litter habitat into a headwater stream, ostensibly driving bottom‐up effects on aquatic primary producer biomass and the macroinvertebrate community. Copyright © 2014 John Wiley & Sons, Ltd.
Adopting A Common Data Model for End-User Web Programming Tools

We observe that end-user web programming tools frequently deal with web data and that there is a clear synergy between these tools. Making them interoperate will benefit both users and researchers alike. The first step toward this goal is to adopt a common data model, such as RDF. More research challenges remain to make them interoperate, such as fleshing out a common API and a unified user interface mechanism for the user to orchestrate the tools to perform complex tasks.
Two Groups of Thellungiella salsuginea RAVs Exhibit Distinct Responses and Sensitivity to Salt and ABA in Transgenic Arabidopsis

Containing both AP2 domain and B3 domain, RAV (Related to ABI3/VP1) transcription factors are involved in diverse functions in higher plants. A total of eight TsRAV genes were isolated from the genome of Thellungiella salsuginea and could be divided into two groups (A- and B-group) based on their sequence similarity. The mRNA abundance of all Thellungiella salsuginea TsRAVs followed a gradual decline during seed germination. In Thellungiella salsuginea seedling, transcripts of TsRAVs in the group A (A-TsRAVs) were gradually and moderately reduced by salt treatment but rapidly and severely repressed by ABA treatment. In comparison, with a barely detectable constitutive expression, the transcriptional level of TsRAVs in the group B (B-TsRAVs) exhibited a moderate induction in cotyledons when confronted with ABA. We then produced the “gain-of-function” transgenic Arabidopsis plants for each TsRAV gene and found that only 35S:A-TsRAVs showed weak growth retardation including reduced root elongation, suggesting their roles in negatively controlling plant growth. Under normal conditions, the germination process of all TsRAVs overexpressing transgenic seeds was inhibited with a stronger effect observed in 35S:A-TsRAVs seeds than in 35S:B-TsRAVs seeds. With the presence of NaCl, seed germination and seedling root elongation of all plants including wild type and 35S:TsRAVs plants were retarded and a more severe inhibition occurred to the 35S:A-TsRAV transgenic plants. ABA treatment only negatively affected the germination rates of 35S:A-TsRAV transgenic seeds but not those of 35S:B-TsRAV transgenic seeds. All 35S:TsRAVs transgenic plants showed a similar degree of reduction in root growth compared with untreated seedlings in the presence of ABA. Furthermore, the cotyledon greening/expansion was more severely inhibited 35S:A-TsRAVs than in 35S:B-TsRAVs seedlings. Upon water deficiency, with a wider opening of stomata, 35S:A-TsRAVs plants experienced a faster transpirational water loss than wild type and 35S:B-TsRAVs lines. Taken together, our results suggest that two groups of TsRAVs perform distinct regulating roles during plant growth and abiotic defense including drought and salt, and A-TsRAVs are more likely than B-TsRAVs to act as negative regulators in the above-mentioned biological processes.
Substrate utilization during exercise performed with and without glucose ingestion in female and male endurance trained athletes.

Compared to males, females oxidize proportionately more fat and less carbohydrate during endurance exercise performed in the fasted state. This study was designed to test the hypothesis that there may also be gender differences in exogenous carbohydrate (CHOexo) oxidation during exercise. Healthy, young males (n = 7) and females (n = 7) each completed 2 exercise trials (90 min cycle ergometry at 60% VO2peak), 1 week apart. Females were eumenorrheic and were tested in the midfollicular phase of their menstrual cycle. Subjects drank intermittently either 8% CHOexo (1 g glucose x kg x h(-1)) enriched with U-13C glucose or an artificially sweetened placebo during the trial. Whole-body substrate oxidation was determined from RER, urinary urea excretion, and the ratio of 13C:12C in expired gas during the final 60 min of exercise. During the placebo trial, fat oxidation was higher in females then in males (0.42 +/- 0.07 vs 0.32 +/- 0.09 g.min(-1). kg LBM(-1) x 10(2)) at 30 min of exercise (p < .05). When averaged over the final 60 min of exercise, the relative proportions of fat, total carbohydrate, and protein were all similar between groups. During CHOexo ingestion, both the ratio of 13C:12C in expired gas (p < .05) and the proportion of energy derived from CHOexo relative to LBM (p < .05) were higher in females compared to males at 75- and 90-min exercise. When averaged over the final 60 min of exercise, the percentage of CHOexo to the total energy contribution tended to be higher in females (14.3 +/- 1.2%) than in males (11.2 +/- 1.2%; p = .05). Compared to males, females may oxidize a greater relative proportion of CHOexo during endurance exercise which, in turn, may spare more endogenous fuel. Based on these observations, ingested carbohydrate may be a particularly beneficial source of fuel during endurance exercise for females.