Miracle-dz/UniFAR-FTUs huggingface dataset:
Variation in the Oxytocin Receptor Gene Is Associated with Face Recognition and its Neural Correlates

The ability to recognize faces is crucial for daily social interactions. Recent studies suggest that intranasal oxytocin administration improves social recognition in humans. Oxytocin signaling in the amygdala plays an essential role for social recognition in mice, and oxytocin administration has been shown to influence amygdala activity in humans. It is therefore possible that the effects of oxytocin on human social recognition depend on mechanisms that take place in the amygdala—a central region for memory processing also in humans. Variation in the gene encoding the oxytocin receptor (OXTR) has been associated with several aspects of social behavior. The present study examined the potential associations between nine OXTR polymorphisms, distributed across the gene, and the ability to recognize faces, as well as face-elicited amygdala activity measured by functional magnetic resonance imaging (fMRI) during incidental encoding of faces. The OXTR 3′ polymorphism rs7632287, previously related to social bonding behavior and autism risk, was associated with participants’ ability to recognize faces. Carriers of the GA genotype, associated with enhanced memory, displayed higher amygdala activity during face encoding compared to carriers of the GG genotype. In line with work in rodents, these findings suggest that, in humans, naturally occurring endogenous modulation of OXTR function affects social recognition through an amygdala-dependent mechanism. These findings contribute to the understanding of how oxytocin regulates human social behaviors.
Multiple-detect ATPG based on physical neighborhoods

Multiple-detect test sets detect single stuck line faults multiple times, and thus have a higher probability of detecting complex defects. But current definitions of what constitutes a new test for a single stuck line fault do not leverage defect locality. Recent work has proposed a new metric to capture quality of a multiple-detect test set based on the number of unique states on lines in the physical neighborhood of a targeted line. This paper presents a new ATPG strategy that uses this metric to generate higher quality multiple-detect test sets
Towards Cross-Domain PDTB-Style Discourse Parsing

Discourse relation parsing is an important task with the goal of understanding text beyond the sentence boundaries. With the availability of annotated corpora (Penn Discourse Treebank) statistical discourse parsers were developed. In the literature it was shown that the discourse parsing subtasks of discourse connective detection and relation sense classification do not generalize well across domains. The biomedical domain is of particular interest due to the availability of Biomedical Discourse Relation Bank (BioDRB). In this paper we present cross-domain evaluation of PDTB trained discourse relation parser and evaluate feature-level domain adaptation techniques on the argument span extraction subtask. We demonstrate that the subtask generalizes well across domains.
Human Cardiac Wall Stress Analysis WithPatient-specific Myocardial Material Properties

A patient-specific model to evaluate cardiac function from a beating heart is needed. Most current cardiac models were constructed using post mortem measurements of animal hearts. To help understand human cardiac mechanics and disease development, a model constructed based on real patient data is important. In this study, we have employed medical imaging techniques to analyze myocardial wall stress. We developed a methodology to determine myocardial material properties using measurements from magnetic resonance images. The finite element method was used to combine this information and perform wall stress calculations. This process was applied to two healthy human subjects to compute myocardial wall stress. We found general agreement in myocardial wall stress between subjects, with results showing higher stress at the inner wall of ventricles. The wall stress distributions in the left ventricle differed between the two subjects; one had a large area of high wall stress, the other had discontinuous bands of higher wall stress.
The Effect of Ondansetron on Acute Opioid Tolerance in Patients Receiving Intrathecal Opioids Prior to Cesarean Delivery

Background Multiple animal studies suggest that ondansetron ameliorates opioid-induced hyperalgesia and tolerance. In this study, we aimed to determine if the administration of ondansetron prior to spinal anesthesia would have an effect on intrathecal opioid-induced acute opioid tolerance, postoperative pain, and analgesic requirements in patients undergoing cesarean delivery with spinal anesthesia. Methods Eighty-six patients undergoing elective cesarean delivery were recruited and randomly allocated to receive either 8 mg intravenous ondansetron (n = 44) or placebo (n = 42) in a prospective, double-blind design. All patients received spinal anesthesia consisting of 15 mg bupivacaine, 20 &mgr;g of fentanyl, and 100 &mgr;g of preservative-free morphine. We used linear mixed-effects models to assess the difference in pain and opioid consumption in the first 24 hours after surgery between the 2 groups. Results No differences between the 2 groups were found in age, body mass index, American Society of Anesthesiologists physical status scores, duration of surgery, or sensory and motor block characteristics. There was no difference between the 2 groups in postoperative pain scores (P = 0.95) or opioid consumption (P = 0.68). Conclusions In patients undergoing cesarean delivery under spinal anesthesia with intrathecal opioids, the administration of ondansetron prior to spinal anesthesia did not significantly affect postoperative pain scores or opioid consumption. Thus, the administration of ondansetron did not have an effect on acute opioid tolerance in our study.
From ‘Virgin Births’ to ‘Octomom’: Representations of Single Motherhood via Sperm Donation in the UK News

Abstract The use of sperm donation by single women has provoked public, professional and political debate. Newspapers serve as a critical means of both broadcasting this debate and effecting a representation of this user group within the public sphere. This study uses the theory of social representations to examine how single motherhood by sperm donation has been represented in the UK news over time. The study sampled news coverage on this topic in eight British newspapers during three 4‐year periods between the years 1988 and 2012. The dataset of news reports (n = 406) was analysed using a qualitative approach. Findings indicated that UK media reports of single women using donor sperm are underpinned by conventional categories of the ‘personal’, the ‘traditional’ and the ‘natural’ that when paired with their corollaries produce a representation of this user group as the social ‘other’. The amount of coverage on this topic over time was found to vary according to the political orientation of different media sources. Using key concepts from social representations theory, this article discusses the relationship between themata and anchoring in the maintenance of representations of the social ‘other’ in mass mediated communication. Findings are explained in relation to theoretical conceptions of the mass media and its position within the public sphere. It is argued that the use of personal narratives in news reports of single mothers by sperm donation may have significant implications for public understandings of this social group. © 2016 The Authors. Journal of Community & Applied Social Psychology published by John Wiley & Sons Ltd.
Metaphone: machine aesthetics meets interaction design

Through our art project, Metaphone, we explored a particular form of aesthetics referred to in the arts tradition as machine aesthetics. The Metaphone machine collects the participant's bio-data, Galvanic Skin Response (GSR) and Heart Rate (HR), creating a process of movement, painting and sound. The machine behaves in machine-like, aesthetically evocative ways: a shaft on two large wheels rotates on the floor, carrying paint that is dripped onto a large sheet of aquarelle paper on the floor according to bio-sensor data. A soundscape rhythmically follows the bio-sensor data, but also has its own machine-like sounds. Six commentators were invited to interact with the machine. They reported a strangely relaxing atmosphere induced by the machine. Based on these experiences we discuss how different art styles can help to describe aesthetics in interaction design generally, and how machine aesthetics in particular can be used to create interesting, sustained, stylistically coherent interactions.
Retrieval activates related words more than presentation

ABSTRACT Retrieving information enhances learning more than restudying. One explanation of this effect is based on the role of mediators (e.g., sand-castle can be mediated by beach). Retrieval is hypothesised to activate mediators more than restudying, but existing tests of this hypothesis have had mixed results [Carpenter, S. K. (2011). Semantic information activated during retrieval contributes to later retention: Support for the mediator effectiveness hypothesis of the testing effect. Journal of Experimental Psychology: Learning, Memory, and Cognition, 37(6), 1547–1552. doi:10.1037/a0024140; Lehman, M. , & Karpicke, J. D. (2016). Elaborative retrieval: Do semantic mediators improve memory? Journal of Experimental Psychology: Learning, Memory, and Cognition, 42(10), 1573–1591. doi:10.1037/xlm0000267]. The present experiments explored an explanation of the conflicting results, testing whether mediator activation during a retrieval attempt depends on the accessibility of the target information. A target was considered less versus more accessible when fewer versus more cues were given during retrieval practice (Experiments 1 and 2), when the target had been studied once versus three times initially (Experiment 3), or when the target could not be recalled versus could be recalled during retrieval practice (Experiments 1–3). A mini meta-analysis of all three experiments revealed a small effect such that retrieval activated mediators more than presentation, but mediator activation was not reliably related to target accessibility. Thus, retrieval may enhance learning by activating mediators, in part, but these results suggest the role of other processes, too.
A Universal Strategy for Intimately Coupled Carbon Nanosheets/MoM Nanocrystals (M = P, S, C, and O) Hierarchical Hollow Nanospheres for Hydrogen Evolution Catalysis and Sodium‐Ion Storage

Intimately coupled carbon/transition‐metal‐based hierarchical nanostructures are one of most interesting electrode materials for boosting energy conversion and storage applications owing to the strong synergistic effect between the two components and appealing structural stability. Herein, a universal method is reported for making hierarchical hollow carbon nanospheres (HCSs) with intimately coupled ultrathin carbon nanosheets and Mo‐based nanocrystals. The in situ and confined reaction of the synthetic strategy can not only allow the aggregation of the nanocrystals to be impeded, but also endows extremely intimate coupled interaction between the conductive carbon nanosheets and the nanocrystals MoM (M = P, S, C and O). As a proof of concept, the as‐prepared MoP/C HCSs exhibit extraordinary hydrogen evolution reaction electrocatalytic activity with small overpotential and robust durability in both acidic and alkaline solutions. In addition, the unique sheet‐on‐sheet MoS2/C HCSs as an anode demonstrate high capacity, great rate capabilities, and long‐term cycles for sodium‐ion batteries (SIBs). The capacity can be maintained at 410 mA h g−1 even after 1000 cycles even at a high current density of 4 A g−1, one of the best reported values for MoS2‐based electrode materials for SIBs. The present work highlights the importance of designing and fabricating functional strongly coupled hybrid materials for enhancing energy conversion and storage applications.
Sedative-hypnotic and anxiolytic effects and the mechanism of action of aqueous extracts of peanut stems and leaves in mice.

INTRODUCTION Peanut stems and leaves (PSL) have traditionally been used as both a special food and a herbal medicine in Asia. The sedative-hypnotic and anxiolytic effects of PSL have been recorded in classical traditional Chinese literature, and more recently by many other researchers. In a previous study, four sleep-related ingredients (linalool, 5-hydroxy-4',7-dimethoxyflavanone, 2'-O-methylisoliquiritigenin and ferulic acid), among which 5-hydroxy-4',7-dimethoxyflavanone and 2'-O-methylisoliquiritigenin were newly found in Arachis species, were screened by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC/QTOF-MS). In the current study, quantitative examination of the above four ingredients was conducted. Serious fundamental functional studies were done in mice, including locomotor activity, direct sleep tests, pentobarbital-induced sleeping time tests, subthreshold dose of pentobarbital tests and barbital sodium sleep incubation period tests, to determine the material base for the sedative-hypnotic and anxiolytic effects of aqueous extracts of PSL. Furthermore, neurotransmitter levels in three brain regions (cerebrum, cerebellum and brain stem) were determined using UHPLC coupled with triple-quadrupole mass spectrometry (UHPLC/QQQ-MS) in order to elucidate the exact mechanism of action. RESULTS Aqueous extract of PSL at a dose of 500 mg kg-1 (based on previous experience), along with different concentrations of the above four functional ingredients (189.86 µg kg-1 linalool, 114.75 mg kg-1 5-hydroxy-4',7-dimethoxyflavanone, 32.4mg kg-1 2'-O-methylisoliquiritigenin and 44.44 mg kg-1 ferulic acid), had a sedative-hypnotic effect by affecting neurotransmitter levels in mice. CONCLUSION The data demonstrate that these four ingredients are the key functional factors for the sedative-hypnotic and anxiolytic effects of PSL aqueous extracts and that these effects occur via changes in neurotransmitter levels and pathways. © 2018 Society of Chemical Industry.
Genetic and morphological data support placement of Myrmotherula gularis (Spix) in the monotypic genus Rhopias Cabanis and Heine (Aves: Passeriformes: Thamnophilidae)

Recent DNA-based phylogenetic analyses of the family Thamnophilidae have shown that the genus Myrmotherula is polyphyletic. Traditional plumage-based taxonomy has been misleading in terms of identifying independently evolving lineages within the complex. Here, we integrate a molecular phylogeny with morphometric information and ancestral reconstruction of syringeal character states of the Musculi vocales ventrales, to investigate the taxonomic position of M. gularis, a species for which phylogenetic affinities have long been uncertain. We show that M. gularis represents a long branch in the tribe Thamnophilini that is not closely related to any other member of the Myrmotherula complex. Its relationships within the tribe remain uncertain because of the lack of phylogenetic resolution at the base of the tribe. M. gularis shares a derived character state of the M. vocalis ventralis with Taraba, Hypoedaleus, and Mackenziaena, which supports a close relationship between M. gularis and the large antshrikes. M. gularis can be diagnosed from Myrmotherula and Epinecrophylla by this condition of its M. vocalis ventralis, and from Isleria by plumage and other morphological traits. The phylogenetic and morphological distinctiveness of M. gularis does not warrant merging it into any other genus. We propose that this species be placed in a monotypic genus, for which the available name Rhopias applies.
The double meaning of a single act: influences of the perceiver and the perceived on cooperative behaviour

The present research examines how a single behaviour that is informative of both the morality and intelligence of a person influences impressions, degree of cooperative behaviour expected from that person, and degree of cooperative behaviour displayed toward that person in a mixed-motive interdependence situation (i.e., a social dilemma). Furthermore, it is investigated how individual differences in social value orientation influence these processes. Participants were provided with behavioural information that could be construed in terms of both morality (high/low) and intelligence (high/low). Consistent with the morality-importance hypothesis, participants assigned greater weight to morality than to intelligence aspects of the information. Congruent with the social value orientation hypothesis (i) only proselfs and not prosocials expected more cooperation from unintelligent than from intelligent others, and (ii) prosocials attended more strongly to morality aspects than proselfs in deciding on own cooperation. Finally, consistent with the relative benefit hypothesis, people overall expected more cooperation than they were willing to display, and this tendency was especially pronounced with others described by moral/unintelligent behaviour, and for people with a proself value orientation. The authors discuss a model describing influences of the perceiver and the perceived on cooperative behaviour. Copyright © 1999 John Wiley & Sons, Ltd.
Implant osseointegration in irradiated bone: an experimental study

BACKGROUND AND OBJECTIVES The aim of this study was to evaluate the effect of radiotherapy on the osseointegration of dental implants in the tibia and the action of platelet-rich plasma (PRP) as an adjuvant therapy. MATERIAL AND METHODS A total of 18 rabbits received two implants in each tibial epiphysis, totalizing 72 implants. The control group (group I) was composed by six rabbits and did not receive radiotherapy. The test groups (II and III) received a single dose of 1727 cGy. Group II was composed by six irradiated animals and group III by six animals that received irradiation and PRP during implant placement. The implant success rate, the bone-implant contact (BIC), and the bone volume were analyzed. RESULTS There was no osseointegration in four of the implants, three in group II and one in group III. Total BIC was significantly higher in group I, when compared to the other groups. There was a significant difference of osteoid BIC only between irradiated animals (group II, 8.5%; group III, 4.7%; p = 0.001). On the other hand, the mineralized BIC was significantly higher in group I. Furthermore, group II had a lower mineralized BIC than group III (p = 0.002). Bone volume was higher in the control group (41.3%), followed by group III (33.4%) and II (25.1%), with differences between groups I and II (p = 0.001) and groups II and III (p = 0.022). CONCLUSIONS The present study showed that both the bone volume and BIC were higher in the control group. However, the failure rates of the implants were low in both irradiated groups. The PRP was a positive adjuvant in the osseointegration process.
Activation of Anti-tumor Immune Response by Ablation of HCC with Nanosecond Pulsed Electric Field

Abstract Locoregional therapy is playing an increasingly important role in the non-surgical management of hepatocellular carcinoma (HCC). The novel technique of non-thermal electric ablation by nanosecond pulsed electric field has been recognized as a potential locoregional methodology for indicated HCC. This manuscript explores the most recent studies to indicate its unique anti-tumor immune response. The possible immune mechanism, termed as nano-pulse stimulation, was also analyzed.
Effect of Intensive Versus Standard Blood Pressure Treatment According to Baseline Prediabetes Status: A Post Hoc Analysis of a Randomized Trial

OBJECTIVE To determine whether the effects of intensive (<120 mmHg) compared with standard (<140 mmHg) systolic blood pressure (SBP) treatment are different among those with prediabetes versus those with fasting normoglycemia at baseline in the Systolic Blood Pressure Intervention Trial (SPRINT). RESEARCH DESIGN AND METHODS This was a post hoc analysis of SPRINT. SPRINT participants were categorized by prediabetes status, defined as baseline fasting serum glucose ≥100 mg/dL versus those with normoglycemia (fasting serum glucose <100 mg/dL). The primary outcome was a composite of myocardial infarction, acute coronary syndrome not resulting in myocardial infarction, stroke, acute decompensated heart failure, or death from cardiovascular causes. Cox regression was used to calculate hazard ratios for study outcomes with intensive compared with standard SBP treatment among those with prediabetes and normoglycemia. RESULTS Among 9,361 participants randomized (age 67.9 ± 9.4 years; 35.5% female), 3,898 and 5,425 had baseline prediabetes and normoglycemia, respectively. After a median follow-up of 3.26 years, the hazard ratio for the primary outcome was 0.69 (95% CI 0.53, 0.89) and 0.83 (95% CI 0.66, 1.03) among those with prediabetes and normoglycemia, respectively (P value for interaction 0.30). For all-cause mortality, the hazard ratio with intensive SBP treatment was 0.77 (95% CI 0.55, 1.06) for prediabetes and 0.71 (95% CI 0.54, 0.94) for normoglycemia (P value for interaction 0.74). Effects of intensive versus standard SBP treatment on prespecified renal outcomes and serious adverse events were similar for prediabetes and normoglycemia (all interaction P > 0.05). CONCLUSIONS In SPRINT, the beneficial effects of intensive SBP treatment were similar among those with prediabetes and fasting normoglycemia.
Generalization Error Bounds for Optimization Algorithms via Stability

Many machine learning tasks can be formulated as Regularized Empirical Risk Minimization (R-ERM), and solved by optimization algorithms such as gradient descent (GD), stochastic gradient descent (SGD), and stochastic variance reduction (SVRG). Conventional analysis on these optimization algorithms focuses on their convergence rates during the training process, however, people in the machine learning community may care more about the generalization performance of the learned model on unseen test data. In this paper, we investigate on this issue, by using stability as a tool. In particular, we decompose the generalization error for R-ERM, and derive its upper bound for both convex and nonconvex cases. In convex cases, we prove that the generalization error can be bounded by the convergence rate of the optimization algorithm and the stability of the R-ERM process, both in expectation (in the order of
Heat‐shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase: clues to a possible strategy for treating ALS

A dominant mutation in the gene for copper‐zinc superoxide dismutase (SOD1) is the most frequent cause of the inherited form of amyotrophic lateral sclerosis. Mutant SOD1 provokes progressive degeneration of motor neurons by an unidentified acquired toxicity. Exploiting both affinity purification and mass spectrometry, we identified a novel interaction between heat‐shock protein 105 (Hsp105) and mutant SOD1. We detected this interaction both in spinal cord extracts of mutant SOD1G93A transgenic mice and in cultured neuroblastoma cells. Expression of Hsp105, which is found in mouse motor neurons, was depressed in the spinal cords of SOD1G93A mice as disease progressed, while levels of expression of two other heat‐shock proteins, Hsp70 and Hsp27, were elevated. Moreover, Hsp105 suppressed the formation of mutant SOD1‐containing aggregates in cultured cells. These results suggest that techniques that raise levels of Hsp105 might be promising tools for alleviation of the mutant SOD1 toxicity.