Miracle-dz/UniFAR-FTUs huggingface dataset:
Coping strategies at the ages 8, 10 and 12

The aim of the cross-sectional study was to reveal what coping strategies 8, 10- and 12-year-old Hungarian students (N = 167) use in situations that are frustrating, either for themselves or their peers. The coping strategies in school situations were assessed by our own questionnaires. The instrument enables the investigation of the following behaviourally observable strategies: physical aggression, verbal aggression, resistance, venting/crying, avoidance, teacher-seeking, peer-seeking, following the norms and following teacher’s instructions. The coping strategies were assessed by teacher-report and self-report questionnaires developed especially for this purpose. The most important finding of this study is that the occurrence of overt aggression increases with age, which is supported by the results of both the self-report and the teacher-report questionnaires. Results obtained by the self-report and teacher-report instruments correlated significantly in all three cohorts (p < .05).
Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function

The molecular mechanisms of skin adaptation to the environmental stress are poorly understood. The aryl hydrocarbon receptor nuclear translocator (Arnt) lies at the intersection of several crucial adaptive pathways. Nevertheless, its role in adaptation of the skin to environmental stress has just begun to be unraveled. Here we show that Arnt is expressed in human and mouse skin in a developmentally dependent manner. Targeted K14-driven deletion of Arnt in the mouse epidermis resulted in early postnatal death, associated with a failure of epidermal barrier function. Gene expression profiling of Arnt-null mouse epidermis revealed upregulation of genes of the epidermal differentiation complex on mouse chromosome 3, including S100a genes (S100a8, S100a9, S100a10) and genes coding for small proline-rich proteins (Sprr1a, Sprr2i, Sprr2j, Sprrl1). HPTLC analysis showed significant accumulation of Cer[NS] and Cer[NH] ceramide species in Arnt-null epidermis, suggesting alterations in lipid metabolism. Continuous retention of corneosomes in Arnt-null epidermis that resulted in an abnormally dense corny layer and impaired desquamation was associated with upregulation of Slpi, an inhibitor of stratum corneum chymotryptic enzyme (SCCE) that plays a key role in corneosome degradation. The functional defects in Arnt-null mouse epidermis underscore the crucial role of Arnt in the maintenance of epidermal homeostasis, especially during the perinatal transition to the ex utero environment.
Mature results of a phase II study of rituximab therapy for nodular lymphocyte-predominant Hodgkin lymphoma.

PURPOSE Universal expression of CD20 by malignant cells in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) led us to evaluate rituximab (R) as a therapeutic option. PATIENT AND METHODS Patients with previously treated or newly diagnosed NLPHL were treated with R (375 mg/m(2) once per week for 4 weeks) or, after a protocol amendment, with R plus R maintenance (MR; administered once every 6 months for 2 years). Primary and secondary outcome measures were progression-free survival (PFS) and overall response rate (ORR), respectively. RESULTS A total of 39 patients were enrolled (R, n = 23; R + MR, n = 16). After four once-per-week treatments, ORR was 100% (complete response, 67%; partial response, 33%). At median follow-ups of 9.8 years for R and 5 years for R + MR, median PFS were 3 and 5.6 years (P = .26), respectively; median overall survival (OS) was not reached. Estimated 5-year PFS and OS for patients treated with R versus R + MR were 39.1% (95% CI, 23.5 to 65.1) and 95.7% (95% CI, 87.7 to 100) versus 58.9% (95% CI, 38.0 to 91.2) and 85.7% (95% CI, 69.2 to 100), respectively. Nine of 23 patients experiencing relapse had evidence of transformation to aggressive B-cell lymphoma; six of these patients had infradiaphragmatic involvement at study entry. CONCLUSION R is an active agent in NLPHL. Although responses are not durable in most patients, a significant minority experience remissions lasting > 5 years. R + MR results in a nonsignificant increase in PFS compared with R. R may be considered in the relapsed setting for NLPHL. The potential for transformation of NLPHL to aggressive B-cell lymphoma underscores the importance of rebiopsy and long-term follow-up.
The Induction Tutor: Mentor, manager or both?

New arrangements for the induction of new teachers into the profession were introduced in England in 1999. Induction tutors and newly qualified teachers were interviewed to ascertain their perceptions of the effectiveness of the statutory arrangements. Findings suggest that, while the changes are viewed positively, there are significant differences in the perceived purposes of the new arrangements and in their translation into practice. We conclude that if induction tutors are to fulfil their function as mentor, facilitator and manager, their training and development needs should receive as much attention as those of the newly qualified teachers.
THE FUNCTIONAL APPROACH TO THE STUDY OF ATTITUDES

At the psychological level the reasons for holding or for changing attitudes are found in the functions they perform for the individual, specifically the functions of adjustment, ego defense, value expression, and knowledge. The conditions necessary to arouse or modify an attitude vary according to the motivational basis of the attitude. Ego-defensive attitudes, for example, can be aroused by threats, appeals to hatred and repressed impulses, and authoritarian suggestion, and can be changed by removal of threat, catharsis, and self-insight. Expressive attitudes are aroused by cues associated with the individual's values and by the need to reassert his self-image and can be changed by showing the appropriateness of the new or modified beliefs to the self-concept. Brain washing is primarily directed at the value-expressive function and operates by controlling all environmental supports of old values. Changing attitudes may involve generalization of change to related areas of belief and feeling. Minimal generalization seems to be the rule among adults; for example, in politics voting for an opposition candidate does not have much effect upon party identification. The author is Professor of Psychology at the University of Michigan, former president of the Society for the Psychological Study of Social Issues, and coeditor of Research Methods in the Behavioral Sciences and Public Opinion and Propaganda.
Are we drawing the right conclusions? The dangers of answer format effects in empirical tourism research.

Empirical tourism research has a long history, and empirically based findings represent an important component of theory development and managerial insight. Nevertheless, empirical data of any kind are susceptible to misinterpretation. The aim of this study is to investigate to which extent empirical tourism research accounts for three sources of potential misinterpretation of results: (1) the occurrence of answer format effects, (2) the occurrence of culturally specific response styles, and (3) the selection of data analytic techniques appropriate for the data format. A review of 43 academic publications from 2000 and 2001 suggests that empirical tourism research is strongly guided by standards that have developed within the tourism research community and are not questioned anymore: ordinal answer formats dominate the field, ordinal data are analyzed using techniques requiring metric data, and cross-cultural response styles are ignored, which is a particularly concerning finding given the amount of cross-cultural comparisons typically undertaken in tourism research. Recommendations for improvement are made.
Exercício físico e fibromialgia/Physical exercise and fibromyalgia

A sindrome da fibromialgia e uma doenca reumatica nao inflamatoria que acomete principalmente as mulheres, sendo que 93% dos atingidos sao de etnia branca. A sindrome da fibromialgia pode ser classificada como primaria, quando nao ha relacao com outra patologia, ou secundaria, quando esta se encontra associada com alguma patologia. O paciente fibromialgico precisa receber tratamento multidisciplinar, ou seja, areas distintas devem trabalhar em conjunto para que haja uma melhora nos sintomas. Dentre os sintomas observados na fibromialgia, o mais comum e a dor cronica e difusa. A literatura apresenta referencias que apontam os efeitos e beneficios do exercicio fisico como forma de tratamento nao-medicamentoso para os portadores da sindrome da fibromialgia. Dentre os exercicios fisicos estao a atividade aerobica, alongamentos e treinamento de forca, entre outros. O objetivo desta revisao e apresentar as formas pelas quais o exercicio fisico pode ser util ao paciente fibromialgico, sobretudo no que tange a melhora dos seus sintomas. http://dx.doi. org/10.4322/cto.2012. 028
Demand Response Contracts as Real Options: A Probabilistic Evaluation Framework Under Short-Term and Long-Term Uncertainties

This paper aims to set up a probabilistic framework to assess the value of a portfolio of demand response (DR) customers under both operational (short-term) and planning (long-term) uncertainties through real options (ROs) modeling borrowed from financial theory. In an operational setting, DR is considered as an RO contract allowing an aggregator seeking to maximize its revenue to sell flexible demand in the day-ahead market and balance its energy portfolio in the balancing markets. Sequential Monte Carlo simulations (SMCS) are used to value DR activation decisions based on market price evolutions. These decisions combine DR physical characteristics and portfolio scheduling optimization, whereby the aggregator chooses to exercise only the contracts probabilistically leading to a profit, also considering the physical payback effects of load recovery. Sensitivity of profits to changing market conditions and payback characteristics is also assessed. In an investment setting, subject to long-term uncertainties, the value of an investment in DR-enabling technology is quantified through the Datar-Mathews RO approach that applies hybrid SMCS and scenario analysis. The results show how the flexibility value of DR can be highlighted by modeling it as RO, particularly in high volatile markets, and how realistic inclusion of payback characteristics significantly decrease the benefits estimated for DR. In addition, the proposed RO framework generally allows hedging of the risks incurred under long-term and short-term uncertainties.
The endorsement of the premises: Assumption‐based or belief‐based reasoning

Three experiments examined the effect on reasoning of the degree of belief in the premises. In Expt 1, 84 adult participants had to evaluate their degree of confidence in the truth of conditional statements, and to evaluate the conclusion of modus ponens (MP) arguments using these statements as the major premise. The same seven-point response format was used for both tasks. In the inference task, 48 per cent of the participants accepted all the MP arguments even when they disagreed with their major premise. The other participants considered that some or all of the conclusions were not certainly true. Moreover, they assigned a degree of belief to each conclusion which was highly correlated with the one they attributed to the major premise. Thus two modes of responding emerged, one which assumed the truth of the premises irrespective of actual beliefs about them, and one which integrated the truth status given to the premises. In Expt 2, one replication and three controls confirmed that non-endorsement of the MP arguments was due to the lack of believability of the premises. In Expt 3, on the usual three-response format, 80 adults were invited to adopt one of these two responding modes with four MP arguments, and then to shift to the other one with a new set of four MP arguments. With the appropriate instructions, assumption-based responding was adopted by only 43 per cent of the participants, and belief-based responding by 98 per cent. Three hypotheses are considered about the second mode of responding.
Population Structure of Pseudomonas aeruginosa from Five Mediterranean Countries: Evidence for Frequent Recombination and Epidemic Occurrence of CC235

Several studies in recent years have provided evidence that Pseudomonas aeruginosa has a non-clonal population structure punctuated by highly successful epidemic clones or clonal complexes. The role of recombination in the diversification of P. aeruginosa clones has been suggested, but not yet demonstrated using multi-locus sequence typing (MLST). Isolates of P. aeruginosa from five Mediterranean countries (n = 141) were subjected to pulsed-field gel electrophoresis (PFGE), serotyping and PCR targeting the virulence genes exoS and exoU. The occurrence of multi-resistance (≥3 antipseudomonal drugs) was analyzed with disk diffusion according to EUCAST. MLST was performed on a subset of strains (n = 110) most of them had a distinct PFGE variant. MLST data were analyzed with Bionumerics 6.0, using minimal spanning tree (MST) as well as eBURST. Measurement of clonality was assessed by the standardized index of association (IA S). Evidence of recombination was estimated by ClonalFrame as well as SplitsTree4.0. The MST analysis connected 70 sequence types, among which ST235 was by far the most common. ST235 was very frequently associated with the O11 serotype, and frequently displayed multi-resistance and the virulence genotype exoS −/exoU +. ClonalFrame linked several groups previously identified by eBURST and MST, and provided insight to the evolutionary events occurring in the population; the recombination/mutation ratio was found to be 8.4. A Neighbor-Net analysis based on the concatenated sequences revealed a complex network, providing evidence of frequent recombination. The index of association when all the strains were considered indicated a freely recombining population. P. aeruginosa isolates from the Mediterranean countries display an epidemic population structure, particularly dominated by ST235-O11, which has earlier also been coupled to the spread of ß-lactamases in many countries.
Information Systems And Rationalisation Of Organisations : An Exploratory Study

In this paper we aim to situate social implications of information systems (IS) within a broader context of progressive rationalisation in modern organisations. More specifically, we examine what roles IS play in increasing rationalisation of organisational processes and what are the implications. Our objective in the paper is twofold: i) to propose a rationality framework that synthesises different approaches to reason and rationality, and ii) to demonstrate how it can be used as a conceptual model for critical analysis of social and organisational consequences of rationalisation in organisations enabled and supported by IS. By drawing on a field study in a retail company, we interpret three IS cases to demonstrate how the rationality framework helps explain different IS-organisation relationships in the light of increasing rationality that entails both substantial benefits and risks.
Professional usability in open source projects: GNOME, OpenOffice.org, NetBeans

Working as a usability professional in the open source arena is a challenging task. The decentralized and engineering-driven approach of open source projects can be at odds with corporate processes and usability engineering methodologies. Nonetheless, there is great potential for large corporations to contribute to open source projects. Providing usability know-how that leads to usable and useful products is a win-win situation for developers, the corporations, and -- most importantly -- the users.
Transcriptional Evidence for Inferred Pattern of Pollen Tube-Stigma Metabolic Coupling during Pollination

It is difficult to derive all qualitative proteomic and metabolomic experimental data in male (pollen tube) and female (pistil) reproductive tissues during pollination because of the limited sensitivity of current technology. In this study, genome-scale enzyme correlation network models for plants (Arabidopsis/maize) were constructed by analyzing the enzymes and metabolic routes from a global perspective. Then, we developed a data-driven computational pipeline using the “guilt by association” principle to analyze the transcriptional coexpression profiles of enzymatic genes in the consecutive steps for metabolic routes in the fast-growing pollen tube and stigma during pollination. The analysis identified an inferred pattern of pollen tube-stigma ethanol coupling. When the pollen tube elongates in the transmitting tissue (TT) of the pistil, this elongation triggers the mobilization of energy from glycolysis in the TT cells of the pistil. Energy-rich metabolites (ethanol) are secreted that can be taken up by the pollen tube, where these metabolites are incorporated into the pollen tube's tricarboxylic acid (TCA) cycle, which leads to enhanced ATP production for facilitating pollen tube growth. In addition, our analysis also provided evidence for the cooperation of kaempferol, dTDP-alpha-L-rhamnose and cell-wall-related proteins; phosphatidic-acid-mediated Ca2+ oscillations and cytoskeleton; and glutamate degradation IV for γ-aminobutyric acid (GABA) signaling activation in Arabidopsis and maize stigmas to provide the signals and materials required for pollen tube tip growth. In particular, the “guilt by association” computational pipeline and the genome-scale enzyme correlation network models (GECN) developed in this study was initiated with experimental “omics” data, followed by data analysis and data integration to determine correlations, and could provide a new platform to assist inachieving a deeper understanding of the co-regulation and inter-regulation model in plant research.
LOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild‐type glioblastoma patients

MGMT promoter methylation status is currently the only established molecular prognosticator in IDH wild‐type glioblastoma multiforme (GBM). Therefore, we aimed to discover novel therapy‐associated epigenetic biomarkers. After enrichment for hypermethylated fractions using methyl‐CpG‐immunoprecipitation (MCIp), we performed global DNA methylation profiling for 14 long‐term (LTS; >36 months) and 15 short‐term (STS; 6–10 months) surviving GBM patients. Even after exclusion of the G‐CIMP phenotype, we observed marked differences between the LTS and STS methylome. A total of 1,247 probes in 706 genes were hypermethylated in LTS and 463 probes in 305 genes were found to be hypermethylated in STS patients (p values < 0.05, log2 fold change ± 0.5). We identified 13 differentially methylated regions (DMRs) with a minimum of four differentially methylated probes per gene. Indeed, we were able to validate a subset of these DMRs through a second, independent method (MassARRAY) in our LTS/STS training set (ADCY1, GPC3, LOC283731/ISLR2). These DMRs were further assessed for their prognostic capability in an independent validation cohort (n = 62) of non‐G‐CIMP GBMs from the TCGA. Hypermethylation of multiple CpGs mapping to the promoter region of LOC283731 correlated with improved patient outcome (p = 0.03). The prognostic performance of LOC283731 promoter hypermethylation was confirmed in a third independent study cohort (n = 89), and was independent of gender, performance (KPS) and MGMT status (p = 0.0485, HR = 0.63). Intriguingly, the prediction was most pronounced in younger GBM patients (<60 years). In conclusion, we provide compelling evidence that promoter methylation status of this novel gene is a prognostic biomarker in IDH1 wild‐type/non‐G‐CIMP GBMs.
On preamble-based channel estimation in OFDM/OQAM systems

In this paper, the problem of preamble-based channel estimation in OFDM offset QAM (OFDM/OQAM) systems under a deterministic channel assumption is studied. Recent results indicate that full (all tones carrying pilot symbols) preambles with equal pilot symbols are locally optimal, in the sense that they yield a local minimum of the mean square error (MSE) performance metric of the estimated channel frequency response (CFR), subject to a total training energy constraint. We study the problem of finding the globally optimal full preamble. We show that under a channel constancy assumption, the global optimum coincides with the full preamble of equal symbols. The same result holds even if the channel constancy assumption is removed. Numerical simulations are presented to support the derived results.
Increasing robustness in GMM speaker recognition systems for noisy and reverberant speech with low complexity microphone arrays

Describes the additive robustness obtained through the combined use of a first acoustic processing step based on a low-complexity microphone array followed by a spectral normalization step. Microphone arrays have been shown to provide good results in reducing different sources of acoustic degradation. However, microphone arrays produce linear filtering effects that need to be compensated in order to obtain a minimal spectral distortion. We present the combination of a microphone array together with different well-known spectral normalization techniques as pre-processing stages to a Gaussian mixture models (GMM) based text-independent speaker recognition system. We show that the combination of these extensively-used techniques in the fields of speech enhancement and robust speaker recognition greatly improves the results obtained when the system is tested in noisy reverberant environments with short utterances from unconstrained conversational speech.
A high-gain high-speed low-power class AB operational amplifier

A gain-enhanced high-speed single-stage class-AB low-power op amp is presented. Positive feedback scheme is used to increase the voltage gain. On the other hand by utilizing current driven bulk technique the output voltage swing is improved. Employing two cross-coupled flipped-voltage-follower blocks, class-AB behavior is achieved to make the op amp compatible for high-speed low-power applications
A novel simplification algorithm for point-sampled surfaces

The surface simplification of point-sampled geometry is one of the key preprocessing techniques for subsequent modeling and visualization algorithms. Based on geometry images, in the paper, we put forward a novel simplification algorithm for point- sampled surfaces. First the point-sampled surfaces are represented as geometry images r(phi,thetas), thetas (r, phi) phi (r, thetas) by projecting their spherical polar coordinates onto a plane. Based on geometry images, the k-nearest neighbors of sample points are then determined significantly fast and their curvatures are estimated. Finally, the point set surfaces are simplified according to the curvature and simplified density. In addition, the quality of the simplified point set surfaces is evaluated using the error measurement method based on the moving least squares surface. This algorithm is very fast, easy to implement and can create high-quality surface approximation with preserving the detail very well and control the simplified density conveniently.