Miracle-dz/UniFAR-FTUs huggingface dataset:
Network Configuration for QoS in MIP System

Mobile IP (MIP) is proposed to manage mobility of devices. Mobile IP makes mobile nodes remain attached to the Internet even if they move away from the current link. However, the operation of MIP takes excessive signaling cost to register because a mobile node has to register with its home agent whenever it changes connectivity of link. Thus, we propose a hierarchical mobile IP with paging (P-HMIP) scheme to reduce the registration cost. Another aim of this paper is to guarantee quality of service (QoS) even if a mobile node moves to another network. We adopt a resource reservation protocol with mobile hosts (MRSVP) to the architecture proposed for mobility management and modify MRSVP to reduce the reservation cost. Then, we derive the signaling cost functions to analyze the performance of the proposed scheme. Using this cost function, we can determine the optimal size of each area which makes the signaling cost minimal.
Cost-Effectiveness of Pertuzumab in Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer.

PURPOSE The Clinical Evaluation of Pertuzumab and Trastuzumab (CLEOPATRA) study showed a 15.7-month survival benefit with the addition of pertuzumab to docetaxel and trastuzumab (THP) as first-line treatment for patients with human epidermal growth factor receptor 2 (HER2) -overexpressing metastatic breast cancer. We performed a cost-effectiveness analysis to assess the value of adding pertuzumab. PATIENT AND METHODS We developed a decision-analytic Markov model to evaluate the cost effectiveness of docetaxel plus trastuzumab (TH) with or without pertuzumab in US patients with metastatic breast cancer. The model followed patients weekly over their remaining lifetimes. Health states included stable disease, progressing disease, hospice, and death. Transition probabilities were based on the CLEOPATRA study. Costs reflected the 2014 Medicare rates. Health state utilities were the same as those used in other recent cost-effectiveness studies of trastuzumab and pertuzumab. Outcomes included health benefits expressed as discounted quality-adjusted life-years (QALYs), costs in US dollars, and cost effectiveness expressed as an incremental cost-effectiveness ratio. One- and multiway deterministic and probabilistic sensitivity analyses explored the effects of specific assumptions. RESULTS Modeled median survival was 39.4 months for TH and 56.9 months for THP. The addition of pertuzumab resulted in an additional 1.81 life-years gained, or 0.62 QALYs, at a cost of $472,668 per QALY gained. Deterministic sensitivity analysis showed that THP is unlikely to be cost effective even under the most favorable assumptions, and probabilistic sensitivity analysis predicted 0% chance of cost effectiveness at a willingness to pay of $100,000 per QALY gained. CONCLUSION THP in patients with metastatic HER2-positive breast cancer is unlikely to be cost effective in the United States.
Hydrogen as a local probe: Diffusion and short-range order in Ti1-yVy alloys.

Diffusion coefficients of hydrogen have been measured in disordered Ti{sub 1{minus}{ital y}}V{sub {ital y}} alloys, as a function of temperature, hydrogen concentration, and alloy composition. Diffusion and electron microprobe analysis data indicate the existence of short-range order (clustering) in Ti{sub 1{minus}{ital y}}V{sub {ital y}} alloys, as observed before in the related Ti{sub 1{minus}{ital y}}Nb{sub {ital y}} alloy system by diffusive x-ray scattering. The diffusion data are analyzed by means of a model, incorporating site-dependent activation energies, effective hydrogen-hydrogen interactions, and selective-blocking factors, generalized for alloys with short-range order. Site energies are calculated by means of the embedded-cluster model, assuming the energy of the hydrogen atoms to be predominantly determined by the nearest-neighbor metal atoms. An approximate relation between the short-range-order parameter {sigma} and the site distribution is established. For {sigma}{lt}0 a chain'' model and for {sigma}{gt}0 a cluster'' model are in good agreement with Monte Carlo calculations. Using the short-range-order parameter {sigma} as the only fit parameter, the short-range order in Ti{sub 1{minus}{ital y}}V{sub {ital y}} alloys is determined from diffusion and solubility data. The quantitative determination of the short-range order in Ti{sub 1{minus}{ital y}}V{sub {ital y}} alloys and Mo{sub 1{minus}{ital y}}Ti{sub {ital y}} alloys from diffusion and solubility data,more » which are in excellent agreement with diffusive x-ray scattering data, shows that hydrogen can be a valuable tool to investigate the microscopic structure of concentrated disordered alloys. « less
Quantifying energy expenditure and physical activity in the context of dose response.

PURPOSE Methods for assessing physical activity (PA) and energy expenditure (EE) were reviewed to identify potential limitations to evaluating and interpreting dose-response relationships between PA and health-related outcomes and to suggest future research directions in this area. METHODS Literature describing PA and EE assessment methodology was reviewed according to the reported validity, reliability, and feasibility of the measurement in epidemiologic studies. A summary of this review is presented for techniques applicable to studying PA or EE among free-living individuals. RESULTS Several methods with varying degrees of precision and feasibility have been used to assess PA and EE in free-living populations. Lack of a gold standard field measure of PA may explain some of the variability in precision among these methods. The most accurate field measure of EE appears to be doubly labeled water; however, this approach has limited feasibility in terms of cost and use in studies of total EE only. Electronic motion sensors and physiologic measures related with EE are limited in their ability to discriminate specific types of PA and by inconvenient measurement procedures. Self-reported PA records and surveys are low-cost, relatively unobtrusive methods of assessing PA and EE in field settings and vary in terms of their format, mode of administration, and degree of detailing habitual PA levels. Disparity in the metric used to quantify PA and EE exists within the current literature, which limits the interpretation and comparison of observed dose-response relationships. CONCLUSIONS Efforts to develop equated methods of assessing PA and EE in free-living populations are needed before a systematic evaluation and interpretation of dose-response characteristics between PA and specific health-related parameters can be undertaken.
Detection of mental stress due to oral academic examination via ultra-short-term HRV analysis

Mental stress may cause cognitive dysfunctions, cardiovascular disorders and depression. Mental stress detection via short-term Heart Rate Variability (HRV) analysis has been widely explored in the last years, while ultra-short term (less than 5 minutes) HRV has been not. This study aims to detect mental stress using linear and non-linear HRV features extracted from 3 minutes ECG excerpts recorded from 42 university students, during oral examination (stress) and at rest after a vacation. HRV features were then extracted and analyzed according to the literature using validated software tools. Statistical and data mining analysis were then performed on the extracted HRV features. The best performing machine learning method was the C4.5 tree algorithm, which discriminated between stress and rest with sensitivity, specificity and accuracy rate of 78%, 80% and 79% respectively.
Evaluation of pharmacy services in emergency departments of Veterans Affairs Medical Centers.

OBJECTIVE In 2008, the American Society of Health-System Pharmacists (ASHP) published a national survey that revealed only 6.8% of hospitals surveyed had a pharmacist assigned to the emergency department (ED) for any period of time. This survey was distributed among general and children's medical-surgical hospitals in the United States and did not include any Veterans Affairs (VA) Medical Centers. To date, there have been no identified survey studies describing the prevalence of pharmacy services within VA EDs. The objectives of this study are to determine the prevalence of dedicated pharmacy services within VA EDs, categorize the types of pharmacy services, determine if interventions/outcomes related to pharmacy services were collected, and assess the desire for pharmacy services in facilities that did not currently have dedicated pharmacy services. METHODS The study was designed as a cross-sectional survey study conducted between January 14, 2010 and March 29, 2010. The study population included Pharmacy Clinical Coordinators employed at a VA facility. An initial email containing a link to the web-based survey was distributed via the national Pharmacy Clinical Coordinator listserv. Results of the survey were analyzed using descriptive statistics. RESULTS The survey was distributed to 153 VA Medical Centers and a total of 33 (21.6%) responses were received. Of the responses, 24 facilities (72.7%) documented the presence of an ED, and of those, 5 (20.8%) indicated that they had a pharmacist dedicated to providing pharmacy services to the ED. The most common pharmacy services provided included medication reconciliation, patient education/ counseling, pharmacotherapy recommendations, ED staff education, precepting activities, adverse drug reaction (ADR) reporting, and ensuring formulary compliance. Three of the 5 facilities documented interventions, with 1 facility documenting ADRs prevented and cost avoidance in addition to interventions. Of the 19 facilities that did not have a pharmacist dedicated to the ED, 16 (84.2%) indicated a desire for such services. CONCLUSION A greater prevalence of ED pharmacy services was reported in VA facilities compared with a national sample of non-VA facilities. Despite the high prevalence and variety of dedicated pharmacy services provided to the ED, documentation of these services remains an area in need of improvement.
pH‐independent entry and sequential endosomal sorting are major determinants of hepadnaviral infection in primary hepatocytes

Entry and intracellular transport of hepatitis B viruses have several unusual, largely unknown aspects. In this study, we explored the mode of virus entry using the duck hepatitis B virus (DHBV) and the primary hepatocyte infection model. Upon internalization, viral particles were enriched in an endosomal compartment, as revealed by biochemical and ultrastructural analysis. Virus‐containing vesicles harbored early endosome markers. Kinetic analysis revealed time‐dependent partial translocation of viral DNA from endosomes into the cytosol. This was strongly reduced by inhibition of vacuolar ATPase; (vATPase) activity with bafilomycin A1 and resulted in abortive infection and prevention of cccDNA formation. Inactivation of vATPase induced accumulation and stabilization of incoming viral particles in endosomes, presumably by blocking endosomal carrier vesicle–mediated cargo transport and sorting. Although neutralization of the endomembrane organelles alone led to stabilization of incoming viral particles, it did not inhibit virus infection. In line with this, a pH‐dependent ectopic virus fusion at the plasma membrane could not be artificially induced. This provided further evidence for a pH‐neutral translocation mechanism. Endosomal membrane potential was required for viral infection because cotreatment of cells with monensin partially overcame the inhibitory effect of bafilomycin A1. In conclusion, hepatitis B viral infection is mediated by a novel cellular entry mechanism with features different from that of all other known viruses. (HEPATOLOGY 2006;44:685–693.)
Participatory Scenarios for Exploring the Future: Insights from Cherry Farming in South Patagonia

This paper describes a study to construct narrative-based scenarios to complement models for exploring the sustainability of cherry production in South Patagonia. The study is part of a European-funded project (EULACIAS) which focuses on the co-innovation of farming systems in Latin America. The authors' approach involves stakeholders analysing the present state of the farming system and then identifying driving forces for change. Finally, the impact of drivers on the farming sector is assessed via a Delphi exercise to capture expert opinion. The outputs from this exercise describe three possible future scenarios, representing ‘opening to new markets’, ‘quality’ and a ‘regional market’. The characteristics of each of these are described in the context of cherry production.
PIK3CA amplification is associated with poor prognosis among patients with curatively resected esophageal squamous cell carcinoma

To investigate the clinicopathologic characteristics and the prognostic impact of PIK3CA gene amplification in curatively resected esophageal squamous cell carcinoma (ESCC). Using 534 curatively resected ESCCs, the PIK3CA gene copy number was evaluated with fluorescent in situ hybridization. PIK3CA amplification was defined as PIK3CA/centromere 3 ratio is ≥ 2.0 or average number of PIK3CA signals/tumor cell nucleus ≥ 5.0. PIK3CA mutations in exon 9 and 20, encoding the highly conserved helical and kinase domains were assessed by direct sequencing in 388 cases. PIK3CA amplification was detected in 56 (10.5%) cases. PIK3CA amplification was significantly associated with higher T-stage (P=0.026) and pathologic stage (P=0.053). PIK3CA amplification showed a significantly shorter disease free survival (DFS) compared with that of non-amplified group (33.4 vs 63.1 months, P=0.019). After adjusting for gender, tumor location, pathologic stage, histologic grade and adjuvant treatment, PIK3CA amplification was significantly associated with a shorter DFS (adjusted hazard ratio [AHR] 1.53; 95% CI, 1.10-2.17; P=0.02). Though the statistical insignificance, PIK3CA amplification showed tendency of shorter OS (52.1 vs 96.5 moths, P=0.116). PIK3CA mutations were detected in 6 (1.5%) of 388 cases; 5 cases with exon 9 mutations in E545K while one exon 20 mutation in H1047L. PIK3CA amplification is a frequent oncogenic alteration and associated with shorter survival, suggesting its role as a prognostic biomarker in resected ESCC. PIK3CA amplification may represent a promising therapeutic target for ESCC.
Main Determinants of PON1 Activity in Hemodialysis Patients

Background/Aims: Cardiovascular diseases are the major cause of morbidity and mortality in hemodialysis (HD) patients. These patients present reduced paraoxonase 1 (PON1) activity that depends on genetic and non-genetic factors; however, how these factors influence PON1 activity in HD patients is poorly clarified. Our aim was to evaluate the influence of two polymorphisms and non-genetic factors on PON1 activity in HD patients. Methods: We evaluated 183 HD patients under recombinant human erythropoietin (rhEPO) treatment and 22 healthy individuals. The lipid profile [total cholesterol, triglycerides, HDL-c, LDL-c, apolipoprotein (Apo) A-I, Apo B, lipoprotein(a) and oxidized low-density lipoprotein (Ox-LDL)], inflammatory markers [adiponectin, interleukin-6 (IL-6) and C-reactive protein (CRP)], PON1 activity and PON1 gene polymorphisms (L55M and Q192R) were evaluated. Results: HD patients presented higher levels of IL-6, CRP and Ox-LDL/LDL-c, and lower PON1 activity, total cholesterol, HDL-c, LDL-c, Apo A and Apo B; the most frequent genotype was heterozygosity for L55M polymorphism and homozygosity for the Q allele, the more frequent genotype of Q192R polymorphism. Multiple regression analysis identified heterozygosity and homozygosity for L55M and Q192R polymorphisms, very low-density lipoproteins, LDL-c, Apo A and CRP levels, time on dialysis and rhEPO dose, as the independent variables significantly associated with PON1 activity. The associations with CRP, rhEPO and time on dialysis were negative. Conclusion: Our results show that the reduced PON1 activity in HD patients who are not under statin therapy is strongly associated with inflammation, longer time on dialysis and high rhEPO doses, suggesting that the reduction in PON1 activity may worsen the prognosis of these patients.
Object relations and reality testing in early- and late-onset schizophrenia.

One hundred fifty-seven U.S. military veterans with schizophrenia were divided into early-onset (i.e., onset at age 20 or before, n = 36) and late-onset (i.e., onset after age 30, n = 28) groups and completed the Bell Object Relations and Reality Testing Inventory (BORRTI), the Positive and Negative Syndrome Scale, and several representative neuropsychological instruments. Participants were compared on background characteristics and test measures. The early-onset group demonstrated significantly more object-relations and reality-testing deficits than the late-onset group. In contrast, no significant group differences were found on symptom or neuropsychological variables. An a posteriori three-group analysis that included the middle age of onset group (i.e., ages 21 to 30) found that the middle group had mean values that fell between early- and late-onset groups on most variables. No distinct patterns of BORRTI subscale scores distinguished the middle group. The finding that object-relations and reality-testing deficits are more pronounced in early-onset schizophrenia has implications for the treatment and rehabilitation of schizophrenia.
Classical and melanopsin photoreception in irradiance detection: negative masking of locomotor activity by light

Studies in mice lacking either classical or melanopsin photoreception have been useful in describing the photoreceptor contribution to irradiance detection in accessory visual responses. However, application of these findings to irradiance detection in intact animals is problematical because retinal degeneration or manipulation can induce secondary changes in the retina. Among responses dependent on irradiance detection, the suppression of activity by light (negative masking) has had limited study. To further understand the function of classical and melanopsin photoreceptors we studied irradiance and spectral sensitivity of masking by light, primarily in mice with intact retinae. The sensitivity of negative masking was equivalent for medium (∼500 nm) and short wavelengths (∼365 nm) in three strains of wild‐type mice, identifying a marked short‐wavelength‐sensitive‐cone input. At medium wavelengths, spectral sensitivity above 500 nm had closest fit to the nomogram for the medium‐wavelength‐sensitive‐cone, but a combined input of cone and melanopsin photoreceptors in wild‐type mice seems likely. Under white light a decompression of the irradiance range of masking in C3H rd/rd cl mice, lacking rods and cones, identified a functional deficiency presumably resulting from the absence of classical photoreceptor input. Together the evidence demonstrates a pronounced and sustained classical photoreceptor input to irradiance detection for negative masking, and suggests one role of classical photoreceptor input is to constrain dynamic range.
The Relationship between Language Ability and Cognitive Function in Patients with Schizophrenia

Objective Cognitive dysfunction is common in people with schizophrenia, and language disability is one of the most notable cognitive deficits. This study assessed the use and comprehension ability of the Korean language in patients with schizophrenia and the correlations between language ability and cognitive function. Methods Eighty-six patients with schizophrenia and a group of 29 healthy controls were recruited. We assessed both clinical symptoms and cognitive functions including Korean language ability. For clinical symptoms, the Positive and Negative Syndrome Scale, Clinical Global Impression-Schizophrenia Scale, and Social and Occupational Functioning Assessment Scale were used. For the Korean language ability assessment, a portion of the Korean Broadcasting System (KBS) Korean Language Test was used. The Short-form of Korean-Wechsler Adult Intelligence Scale, the Korean version of the University of California San Diego (UCSD) Performance-based Skills Assessment (K-UPSA), and the Wisconsin Card Sorting Test (WCST) were used to assess cognitive functions. Results Schizophrenic patients had significantly lower scores in the language and cognitive function tests both in the total and subscale scores. Various clinical scores had negative correlations with reading comprehension ability of the KBS Korean Language Test. The WCST and a part of the K-UPSA had positive correlations with multiple domains of the language test. Conclusion A significant difference was found between schizophrenic patients and controls in language ability. Correlations between Korean language ability and several clinical symptoms and cognitive functions were demonstrated in patients with schizophrenia. Tests of cognitive function had positive correlations with different aspects of language ability.
Neural correlates of prediction violations in boys with Tourette syndrome: Evidence from harmonic expectancy

Abstract Objectives: It has been suggested that Tourette syndrome (TS) might be associated with alterations of the attention system, but the nature of these alterations and the underlying neuroanatomical network remains elusive. We aimed at investigating the functional neuroanatomical modulators of attention allocation towards predictable versus unpredictable stimuli in boys with TS. Methods: Using functional magnetic resonance imaging, we ran a harmonic expectancy violation paradigm in 17 boys with TS and 23 matched healthy controls (HCs). We presented chord sequence in which the first four chords induced a strong expectancy for a harmonic chord at the next position. In 70% this expectancy was fulfilled (harmonic), in 30% the expectancy was violated (disharmonic). Results: HCs responded faster to the disharmonic compared to harmonic chords, indicating a stronger attention allocation towards unpredictable stimuli, while this effect was not found in boys with TS. HCs showed stronger anterior cingulate cortex (ACC) activation during disharmonic compared to harmonic chords. Boys with TS showed stronger ACC activation during harmonic chords, which was associated with greater tic severity. Conclusions: Our findings indicate that boys with TS showed altered reactions towards predictable versus unpredictable stimuli in brain regions playing an important role in attention control. This might indicate altered allocation of attention towards those stimuli.