Miracle-dz/UniFAR-FTUs huggingface dataset:
Robots in the wild: Understanding long-term use

It has long been recognized that novelty effects exist in the interaction with technologies. Despite this recognition, we still know little about the novelty effects associated with domestic robotic appliances and more importantly, what occurs after the novelty wears off. To address this gap, we undertook a longitudinal field study with 30 households to which we gave Roomba vacuuming robots and then observed use over six months. During this study, which spans over 149 home visits, we encountered methodological challenges in understanding households' usage patterns. In this paper we report on our longitudinal research, focusing particularly on the methods that we used 1) to understand human-robot interaction over time despite the constraints of privacy and temporality in the home, and 2) to uncover information when routines became less conscious to the participants themselves.
Primes compete for responses with taregts evidence for a combind mechanism underlying affective priming in naming task

The current experiment showed that larger affective priming effect (i.e., faster responses to positive and negative targets that are preceded by valence-congruent compared to incongruent primes) in naming task could be obtained when the prime and target were having the similar pronunciation than when they pronounced differently. On the basis of this pattern of results, it argued that the affective priming effect was due to dual mechanism of both encoding facilitation and response competition. These results also indicated that repeated failures to find such effect using language stimuli were probably due to not taking the response competition process into account.
Exploring the perception of social characteristics in faces using the isolation effect

The age, sex, and distinctiveness of faces can be judged from objective and partially independent facial features. In contrast, the physical basis of other social judgements, such as attractiveness, intelligence, and trustworthiness is not as yet entirely understood, despite the consistency of these judgements from faces. The present set of experiments investigated the perception of social characteristics in faces, using an adaptation of the von Restorff/isolation paradigm to determine which social characteristics are spontaneously encoded from the face. The isolation effect involves enhanced memory for perceptually salient items in a list (items that are isolated in the sense that they are in numeric minority) and our results suggested that its locus is at the encoding stage of the recognition memory experiment. Isolation in the present experiments was achieved by manipulating the number of faces included in the sets on the basis of certain characteristics. Because the manipulation of the characteristics of faces in a set to be learnt was not mentioned in most of the experiments, any resulting memory increment for the isolated items could be taken as an index of spontaneous processing of the manipulated social characteristic. Age and sex were found to be spontaneously encoded from faces. Results for other characteristics were mixed, ranging from distinctiveness and attractiveness, for which there was some indication of spontaneous processing, to intelligence and trustworthiness, which did not seem to be spontaneously encoded from faces. For intelligence, an isolation effect was found only when the experiment required a judgement that led to activation of the appropriate stereotype.
Critical thinking about fables: examining language production and comprehension in adolescents.

PURPOSE This study was designed primarily to determine if a critical-thinking task involving fables would elicit greater syntactic complexity than a conversational task in adolescents. Another purpose was to determine how well adolescents understand critical-thinking questions about fables. METHOD Forty adolescents (N=20 boys and 20 girls; mean age=14 years) with typical language development answered critical-thinking questions about the deeper meanings of fables. They also participated in a standard conversational task. The syntactic complexity of their responses during the speaking tasks was analyzed for mean length of communication unit (MLCU) and clausal density (CD). RESULTS Both measures of syntactic complexity, MLCU and CD, were substantially greater during the critical-thinking task compared with the conversational task. It was also found that the adolescents understood the questions quite well, earning a mean accuracy score of 80%. CONCLUSIONS The critical-thinking task has potential for use as a new type of language-sampling tool to examine language production and comprehension in adolescents.
Skin and Nail Responses after 1 Year of Infliximab Therapy in Patients with Moderate-to-Severe Psoriasis: A Retrospective Analysis of the EXPRESS Trial

Background: The EXPRESS study demonstrated the initial efficacy of infliximab in psoriasis affecting the skin and nails. Objective: To further assess how patients with a positive initial response to infliximab respond to 1 year of continuous infliximab treatment. Methods: A retrospective analysis of patients with moderate-to-severe plaque and nail psoriasis who initiated and continued infliximab treatment up to week 46 was conducted. Results: Among all nail psoriasis patients receiving 1 year of infliximab (n = 186), 74.6 and 54.1% achieved at least 75 or 90% improvement in the Psoriasis Area and Severity Index (PASI) at week 50. These PASI-75 (n = 138) and PASI-90 (n = 100) responders had respective mean improvements from baseline to week 50 of 93.6 and 97.3% for the PASI, 90.6 and 94.1% for the Dermatology Life Quality Index (DLQI) and 78.2 and 80.3% for the Nail Psoriasis Severity Index (NAPSI). Conclusions: Infliximab treatment for 1 year produced sustained improvement in PASI, DLQI and NAPSI scores.
Screening for Familial Hypercholesterolemia in 5000 Neonates: A Recall Study

ABSTRACT: To investigate the feasibility of screening for familial hypercholesterolemia, apolipoprotein B (Apo B) levels were determined in dried blood spot samples on neonatal screening cards from 5000 consecutively born neonates, by radial immunodiffusion assay. The 103 infants with Apo B levels in the top 2% were recalled for repeat dried blood spot Apo B determinations. Forty-five of the 103 infants were retested, and serum lipid profiles and Apo B levels were determined for both parents of 43 of these infants, and for the mother only for the other two infants. The recalled “top 2%” group had a higher proportion of females, a higher mean birth weight, a higher mean gestational age and a higher proportion of infants sampled initially on day 5 than in the total screened population, consistent with our previously determined influence of these factors on Apo B levels at screening. The retested group (n = 45) was representative of the total recalled group (n = 103) with respect to Apo B levels at screening, sex, birth weight, gestational age, and age at sampling for screening. The infants' mean ± SD age at retesting was 12.3 ± 3.3 months. Their mean Apo B value on retesting was 0.65 ± 0.20 g/liter of whole blood (range 0.30 to 1.16 g/liter). Two fathers had had coronary bypass surgery by the age of 40 and had type II lipid profiles and elevated serum Apo B levels. For both, their child had elevated Apo B levels at recall (both 1.05 g/liter of whole blood). Another five mothers and five fathers had type II lipid profiles (total and low-density lipoprotein cholesterol more than 95th percentile for their age and sex), and in four of these their child also had elevated Apo B levels at recall (≥0.70 g/liter of whole blood). Another eight infants had recall Apo B levels of more than 0.70 g/liter, of whom two had only had one parent with low-density lipoprotein cholesterol more than the 90th percentile suggesting genetically determined elevated levels. Despite the arbitrary cutoff point, a total of six of the 45 infants retested had strong indications of having the gene for familial hypercholesterolemia. This gives an estimated frequency of between one in 365 and one in 830 in the total population screened, which is comparable with the reported frequency of one in 500. We conclude that screening for familial hypercholesterolemia using this method is feasible, but that a further study using a cutoff point that takes into account the factors that affect Apo B levels at screening would be useful.
A Compact RF CMOS Modeling for Accurate High-Frequency Noise Simulation in Sub-100-nm MOSFETs

A compact RF CMOS model incorporating an improved thermal noise model is developed. Short-channel effects (SCEs), substrate potential fluctuation effect, and parasitic-resistance-induced excess noises were implemented in analytical formulas to accurately simulate RF noises in sub-100-nm MOSFETs. The intrinsic noise extracted through a previously developed lossy substrate de-embedding method and calculated by the improved noise model can consistently predict gate length scaling effects. For 65- and 80-nm n-channel MOS with fT above 160 and 100 GHz, NFmin at 10 GHz can be suppressed to 0.5 and 0.7 dB, respectively. Drain current noise Sid reveals an apparently larger value for 65-nm devices than that for 80-nm devices due to SCE. On the other hand, the shorter channel helps reduce the gate current noise Sig attributed to smaller gate capacitances. Gate resistance Rg-induced excess noise dominates in Sig near one order higher than the intrinsic gate noise that is free from Rg for 65-nm devices. The compact RF CMOS modeling can facilitate high-frequency noise simulation accuracy in nanoscale RF CMOS circuits for low-noise design.
RANK receptor oligomerisation in the regulation of NFκB signalling

The interaction of receptor activator of NFκB (RANK), a member of the tumour necrosis factor receptor superfamily, with RANK ligand is crucial for the formation, function and survival of osteoclasts. The role of the cytoplasmic oligomerisation domain (pre-ligand assembly domain; PLAD or ‘IVVY’ motif) in the ligand-dependent activation of downstream NFκB signalling has not been studied previously. The discovery of truncating mutations of TNFRSF11A (W434X and G280X that lack the PLAD) as the cause of rare cases of osteoclast-poor osteopetrosis offered the opportunity for functional study of this region. Recapitulating the W434X mutation by transcription activator-like effector nuclease (TALEN)-mediated targeted disruption of Tnfrsf11a within the region homologous to W434X in the mouse macrophage-like cell line RAW264.7 impaired formation of osteoclast-like cells. Using overexpression studies, we demonstrated that, in contrast to WT-RANK, the absence of the PLAD in G280X-RANK and W434X-RANK prevented ligand-independent but not ligand-dependent oligomerisation. Cells expressing W434X-RANK, in which only two of the three TRAF6-binding motifs are present, continued to exhibit ligand-dependent NFκB signalling. Hence, the absence of the PLAD did not prevent ligand-induced trimerisation and subsequent NFκB activation of RANK, demonstrating that therapeutic targeting of the PLAD in the prevention of osteoporosis may not be as effective as proposed previously.
Diffuse Reverberation Model for Efficient Image-Source Simulation of Room Impulse Responses

In many research fields of engineering and acoustics, the image-source model represents one of the most popular tools for the simulation of sound fields in virtual reverberant environments. This can be seen as a result from the relative simplicity and flexibility of this particular method. However, the associated computational costs constitute a well known drawback of image-source implementations, as the required simulation times grow exponentially with the considered reflection order. This paper proposes a method that allows for a fast synthesis of room impulse responses according to the image-source technique. This is achieved by modeling the diffuse reverberation tail as decaying random noise, where the decay envelope for the considered acoustic environment is determined according to a recently proposed method for the prediction of energy decay curves in image-source simulations. The diffuse reverberation model presented in this paper thus produces impulse responses that are representative of the specific virtual environment under consideration (within the general assumptions of geometrical room acoustics), in contrast to other artificial reverberation techniques developed on the basis of perceptual measures or assuming a purely exponential energy decay. Furthermore, since image-source simulations are only used for the computation of the early reflections, the proposed approach achieves a reduction of the computational requirements by up to two orders of magnitude for the simulation of full-length room impulse responses, compared to a standard image-source implementation.
Maturation of the long-latency auditory ERP: step function changes at start and end of adolescence

The auditory event-related potential (ERP) is obtained by averaging electrical impulses recorded from the scalp in response to repeated stimuli. Previous work has shown large differences between children, adolescents and adults in the late auditory ERP, raising the possibility that analysis of waveform shape might be useful as an index of brain maturity. We reanalysed auditory ERPs from samples previously described by Albrecht, von Suchodoletz and Uwer (2000) and Uwer, Albrecht and von Suchodoletz (2002), using the intraclass correlation (ICC) as a global measure of similarity of an individual's waveform to a grand average comparison waveform for each age band. Three developmental periods were clearly distinguished: 5 to 12 years, 13 to 16 years, and adulthood. However, within each of these periods, there was no evidence of any developmental progression with age.
Conditional Expression of a Dominant-Negative c-Myb in Vascular Smooth Muscle Cells Inhibits Arterial Remodeling After Injury

Abstract— Inhibiting activity of the c-Myb transcription factor attenuates G1 to S phase cell cycle transitions in vascular smooth muscle cells (SMCs) in vitro. To determine the effects of arterial SMC-specific expression of a dominant-negative c-Myb molecule (Myb-Engrailed) on vascular remodeling in vivo, we performed carotid artery wire-denudation in 2 independent lines of binary transgenic mice with SM22&agr; promoter-defined Doxycycline-suppressible expression of Myb-Engrailed. Adult mice with arterial SMC-specific expression of Myb-Engrailed were overtly normal in appearance and did not display any changes in cardiovascular structure or physiology. However, bromodeoxyuridine-defined arterial SMC proliferation, neointima formation, medial hyperplasia, and arterial remodeling were markedly decreased in mice expressing arterial SMC-restricted Myb-Engrailed after arterial injury. These data suggest that c-Myb activity in arterial SMCs is not essential for arterial structure or function during development, but is involved in the proliferation of arterial SMCs as occurs in vascular pathology, and that the expression of a dominant-negative c-Myb can dramatically reduce adverse arterial remodeling in an in vivo model of restenosis. As such, this model represents a novel tissue-specific strategy for the potential gene therapy of diseases characterized by arterial SMC proliferation.
Examining Racism, Power, and White Hegemony in Stodolska's Conditioned Attitude Model of Individual Discriminatory Behavior

Monica Stodolska has developed a “conditioned attitude model of individual discriminatory behavior” in an attempt to understand and predict how people acquire prejudicial attitudes and how such attitudes may manifest in discriminatory practices. On the face of it, she seems to make a reasonable argument as to why such a model is needed and how her model differs from existing models in psychology and sociology. Indeed, one would be hard pressed not to agree with the idea that if leisure researchers could isolate the factors that might contribute to people acquiring prejudicial attitudes that subsequently lead them to engage in discriminatory practices, then theoretically we might be able to reduce prejudice and one of its manifestations, discrimination. Who would find such an endeavor objectionable? Yet, it is precisely the silences and omissions of her paper that are both provocative and problematic. Three components of her argument—race, ethnicity and leisure—are not clarified and defined. Interestingly, Stodolska has remained silent on issues of racism and provides only a cursory discussion of power—both of which, I argue, are central to understanding issues of prejudice and discrimination. By not defining what constitutes race and ethnicity, she leaves open the implication that “whiteness” is not a racial and/or ethnic category and thus, seems to be reinforcing an “us” and “them” dichotomy around issues of race, ethnicity, prejudice, discrimination and racism. Her failure to define leisure is equally problematic. The examples for leisure that she does use take whiteness and historically “white” definitions of leisure as the basis for the existence of discrimination relative to the lack of participation and under participation in leisure settings such as “. parks, beaches, campgrounds, golf courses and other recreation areas. ” (Stodolska, 2005, p. 2). Historically, researchers have measured and examined discrimination in terms of the “lack” of participation in certain leisure settings. Yet, not participating in leisure activities that have primarily been associated with white people does not necessarily mean that people are not engaging in leisure, and that the lack of engagement necessarily equals discrimination, an implied claim that could be read into Stodolska’s argument. I, however, am not suggesting that race and ethnic-based discrimination as a practice rooted in the institutionalized and systemic power that one group has over another does not exist in public leisure settings. Rather, I am challenging Stodolska to clarify her use of the term “leisure” relative to issues of race and ethnic-based discrimination and racism. Ultimately, I am not convinced that a scientifically based model is needed to understand and predict which individuals and groups of people are most likely to engage in
REOG AS MEANS OF STUDENTS’ APPRECIATION AND CREATION IN ARTS AND CULTURE BASED ON THE LOCAL WISDOM

This paper is the result of the study and the implementation of learning in the field of the author, especially in the implementation of the study of Arts and Culture in the vocational schools. The purpose of this paper is to show that by learning local culture based on learning objectives the corresponding to the curriculum can be reached. In fact, the local culture also containing more local wisdom is felt directly by the students. The art of Reog, known around Pringapus Semarang Regency, can be used as a means of learning arts for students, especially in the activities of appreciation and expressions. The existing values in the art of Reog can be conceptually presented in class, as well as directly through the students’ activities of appreciation and expression in the form of performances in the school environment. Students can easily receive learning materials and can be more expressive while presenting the show. The values that are in the presentation of the art of Reog are social, religion, nationalism, and culture. Students can present Reog with enthusiasm and expressive as a show that has already exist for a long time in the environment of their own, and even many have become the performers of Reog in their neighborhood. Reog has already been part of his life that has the role of self-actualization, expression, social, and cultural. Most of those students feel proud to be a part in the show in his living quarters so that they do not feel ashamed of serving the art in school.
Face Sketch Synthesis Algorithm Based on E-HMM and Selective Ensemble

Sketch synthesis plays an important role in face sketch-photo recognition system. In this manuscript, an automatic sketch synthesis algorithm is proposed based on embedded hidden Markov model (E-HMM) and selective ensemble strategy. First, the E-HMM is adopted to model the nonlinear relationship between a sketch and its corresponding photo. Then based on several learned models, a series of pseudo-sketches are generated for a given photo. Finally, these pseudo-sketches are fused together with selective ensemble strategy to synthesize a finer face pseudo-sketch. Experimental results illustrate that the proposed algorithm achieves satisfactory effect of sketch synthesis with a small set of face training samples.
Stress-Driven Discovery of Novel Cryptic Antibiotics from a Marine Fungus Penicillium sp. BB1122

Standard laboratory cultures have long been known to hinder activation of specific gene clusters which in turn hamper production of secondary metabolites with unique properties due to lack of innovation or the inability to trigger cryptic gene clusters’ expression. Due to challenges related to the avoidance of the isolation of replicated metabolites, resistance-developing pathogens are to be addressed by the scientific community worldwide in order to progress with novel and potent compounds which could further be developed in the future for pharmaceutical usage. This study reports the isolation of novel cryptic antibiotics from a marine fungus Penicillium sp. BB1122 collected from Zhoushan coast by applying the “metal-stress” strategy, here referring to the heavy metal cobalt (6 mM). High-performance liquid chromatography-guided isolation of four novel and four known compounds belonging to the polyketide class has been carried out where their relative as well as absolute configurations have been determined using spectroscopic analysis techniques as well as by the comparison of theoretically calculated ECD spectrum and the experimental ECD spectrum, respectively. The structures of novel compounds 7 and 8 represent the first example of 2,5-dioxabicyclo[2.2. 1]heptane pyrone backbone bearing a migrated polyene chain. The novel compounds 7, 8, and 5 exhibited impressive antibiotic properties against methicillin resistant Staphylococcus aureus (MRSA) with MIC value of around 0.5 and 1 μg/mL, respectively. Moreover, the new compounds 1, 7, and 8 displayed potent antibiotic activities with MIC values of around 4 μg/mL against the pathogenic Pseudomonas aeruginosa. Moreover, the MBC of the different potent compounds ranged from 1 to 128 μg/mL against MRSA, P. aeruginosa, and Klebsiella pneumoniae. In addition, the cytotoxic activities were also evaluated where new antibiotics 7 and 8 were not obviously harmful toward normal liver cell lines LO2, showing IC50 values above 100 μg/mL. As a consequence, the results from this study unveiled that cobalt stress is an effective strategy to discover novel antibiotics from microorganisms.
Objective Subjectification: The Antimethod of Social Work

This article sets out to understand an important paradox in the author's action research cooperation with a social work development project called "Wild Learning": the fact that the methods developed in the project mostly consist in antimethod. A sketch of the theoretical concepts in the dialectical tradition of method, objectification, subjectification, and participation is presented to explain the idea that social work itself represents a paradoxical form of knowledge, which can be only inadequately and temporarily objectified as method by way of what is introduced as a "boundary objectivity. " Current "postmodern" forms of this paradox are briefly considered. As a conclusion, an overall understanding of social work as "critique" is suggested, in which both "method" and "antimethod" are necessary moments in a continuous transformation.