Miracle-dz/UniFAR-FTUs huggingface dataset:
A New Homozygous ABCB4 Mutation Identified in Two Chinese Siblings Based on Exome Sequencing

Background: Many pediatric cholestatic liver diseases show unspecific symptoms, laboratory tests and histological features. A complete genetic background check is necessary to identify the genetic determinants as well as the diagnosis and differential diagnosis. Method: The whole genome exome sequencing was performed in two Chinese sister siblings with unspecific cholestasis and the data was analyzed. Results: A homozygous mutation, c.2176C-T transition (p.P726L) in exon 17 of ABCB4, was identified. Further study indicated that there are mutant alleles in the genome of their non consanguineous parents. The final diagnosis is progressive familial intrahepatic cholestasis (PFIC), type 3. Conclusion: As a rare hereditary cholestatic liver disease, PFIC shares many similar features with other hereditary or acquired liver disease and requires a wide range of differential diagnosis. Exome sequencing is a useful tool for mapping this kind of monogenic disease mutation and plays a very important role in genetic counseling and prenatal diagnosis.Background: Many pediatric cholestatic liver diseases show unspecific symptoms, laboratory tests and histological features. A complete genetic background check is necessary to identify the genetic determinants as well as the diagnosis and differential diagnosis. Method: The whole genome exome sequencing was performed in two Chinese sister siblings with unspecific cholestasis and the data was analyzed. Results: A homozygous mutation, c.2176C-T transition (p.P726L) in exon 17 of ABCB4, was identified. Further study indicated that there are mutant alleles in the genome of their non consanguineous parents. The final diagnosis is progressive familial intrahepatic cholestasis (PFIC), type 3. Conclusion: As a rare hereditary cholestatic liver disease, PFIC shares many similar features with other hereditary or acquired liver disease and requires a wide range of differential diagnosis. Exome sequencing is a useful tool for mapping this kind of monogenic disease mutation and plays a very important role in genetic counseling and prenatal diagnosis.
A procedure for obtaining pure absorption 2D J-spectra: application to quantitative fully J-decoupled homonuclear NMR spectra.

The phase-twisted lines, resulting from a double complex Fourier transform, can greatly alter the quality of two-dimensional spectra. This problem, which is generally overcome by experimental procedures (requiring twice as much time as a standard measurement), is inevitable in the two-dimensional J-resolved experiment. This experiment is revisited theoretically and a postprocessing treatment, leading to pure 2D J-spectra, is deduced. Quantitative fully J-decoupled homonuclear spectra are accordingly obtained by means of a projection onto the F2 axis after a 45 degrees tilt.
Acute Kidney Outreach to Reduce Deterioration and Death (AKORDD) trial: the protocol for a large pilot study

Introduction Acute kidney injury (AKI) contributes to morbidity and mortality, and its care is often suboptimal and/or delayed. The Acute Kidney Outreach to Reduce Deterioration and Death (AKORDD) study is a large pilot testing provision of early specialist advice, to improve outcomes for patients with AKI. Methods and analysis This before and after study will test an Outreach service for adult patients with AKI, identified using the national algorithm. During the 2-month before phase, AKI outcomes (30-day mortality, need for dialysis or AKI stage deterioration) will be observed in the intervention and control hospitals and their respective community areas; no interventions will be delivered. Patients will receive good standard care. During the 5-month after phase, the intervention will be delivered to patients with AKI in the intervention hospital and its area. Patients with AKI in the control hospital and its area will continue to have good standard care only. Patients already on dialysis and at end of life will be excluded. The interventions will be initially delivered via a phone call, with or without a visit to the primary clinician, aiming at rapidly establishing the aetiology, correcting reversible causes and conducting further appropriate investigation. Surviving stage 3 patients will be followed-up in an AKI clinic. We will conduct qualitative research using focus group-based discussions with primary and secondary care clinicians during the early and late phases of the trial. This will help break down potential barriers and improve care delivery. Ethics and dissemination Patients will be contacted about the study allowing them to ‘opt out’. The work of an Outreach team, guided by AKI alerts and delivering timely advice to clinicians, may improve outcomes. If the results suggest that benefits are delivered by an AKI Outreach team, this study will lead to a full cluster randomised trial. Trial registration number NCT02398682: Pre-results.
Inducible Metabolism of Phenolic Acids inPediococcus pentosaceus Is Encoded by an Autoregulated Operon Which Involves a New Class of Negative Transcriptional Regulator

ABSTRACT Pediococcus pentosaceus displays a substrate-inducible phenolic acid decarboxylase (PAD) activity on p-coumaric acid. Based on DNA sequence homologies between the three PADs previously cloned, a DNA probe of the Lactobacillus plantarum pdc gene was used to screen a P. pentosaceus genomic library in order to clone the corresponding gene of this bacteria. One clone detected with this probe displayed a low PAD activity. Subcloning of this plasmid insertion allowed us to determine the part of the insert which contains a 534-bp open reading frame (ORF) coding for a 178-amino-acid protein presenting 81.5% of identity with L. plantarum PDC enzyme. This ORF was identified as thepadA gene. A second ORF was located just downstream of thepadA gene and displayed 37% identity with the product of the Bacillus subtilis yfiO gene. Subcloning, transcriptional analysis, and expression studies with Escherichia coli of these two genes under the padA gene promoter, demonstrated that the genes are organized in an autoregulated bicistronic operonic structure and that the gene located upstream of the padA gene encodes the transcriptional repressor of thepadA gene. Transcription of this pad operon inP. pentosaceus is acid phenol dependent.
Parallel performance measures for volume ray casting

Describes a technique for achieving fast volume ray-casting on parallel machines, using a load-balancing scheme and an efficient pipelined approach to compositing. We propose a new model for measuring the amount of work one needs to perform in order to render a given volume, and we use this model to obtain a better load-balancing scheme for distributed memory machines. We also discuss in detail the design trade-offs of our technique. In order to validate our model, we have implemented it on the Intel iPSC/860 and the Intel Paragon, and conducted a detailed performance analysis. <<ETX>>
The estimate for DOAs of signals using sparse recovery method

This paper presents a new direction-of-arrival (DOA) estimation method using the concept of sparse representation of an array cross-correlation vector (ACCV), in which DOA estimation is achieved by finding the sparse parameter vector according to an optimization criterion. Compared with other sparse recovery algorithms the proposed method achieves a higher resolution and has a less computational complexity. The performance of our method is demonstrated and analyzed through numerical simulations.
Linguistic and interactional features of Internet relay chat

L'A. prend pour donnees d'analyse un mode synchronique de Communication Mediatisee par Ordinateur appele Internet Relay Chat (IRC). Ces donnees sont en anglais (provenant d'un canal australien) et en francais. L'A. fournit une taxonomie des traits qui caracterisent ce genre de communication. Il souligne le caractere essentiellement oral de l'IRC en montrant comment les participants tentent de reproduire certains aspects de la langue parlee a l'aide de moyens graphiques et orthographiques
Secure and Efficient Data Transfer in WSN

Wireless sensor networks are one of the largest growing types of networks today. They consist of Thousands of inexpensive nodes, each having sensing capability with limited computational and communication power. Their reliability, cost-effectiveness, ease of deployment and ability to operate in an unattended environment, among other Positive characteristics make sensor networks the leading choice of networks for these applications. Here pattern generation for data aggregation is performed securely by allowing a sensor network to aggregate encrypted data without first decrypting it. In this pattern generation process, initially when a sensor node senses an event from the environment, a pattern code is generated and sends to the cluster head. This generated pattern code is compared with the existing pattern code in the cluster head and then reception of the acknowledgement, Authentication and the transmission of actual data then follows. The simulator used for the implementation is GloMoSim Network Simulator (Global Mobile Information Systems Simulation Library). This is more efficient due to aggregated data transmission, secure and bandwidth efficient.
A Probabilistic Approach for Image Retrieval Using Descriptive Textual Queries

We address the problem of image retrieval using textual queries. In particular, we focus on descriptive queries that can be either in the form of simple captions (e.g., ``a brown cat sleeping on a sofa''), or even long descriptions with multiple sentences. We present a probabilistic approach that seamlessly integrates visual and textual information for the task. It relies on linguistically and syntactically motivated mid-level textual patterns (or phrases) that are automatically extracted from available descriptions. At the time of retrieval, the given query is decomposed into such phrases, and images are ranked based on their joint relevance with these phrases. Experiments on two popular datasets (UIUC Pascal Sentence and IAPR-TC12 benchmark) demonstrate that our approach effectively retrieves semantically meaningful images, and outperforms baseline methods.
Does Occipital Alpha Neurofeedback Require Critical Branching to Causally Influence LTRCs and Deterministic ERPs

Critical branching is a form of theoretical interaction between simple units, which, in the case of the human brain are assumed to be neuronal elements. Zhigalov, Kaplan, & Palva (Clin Neurophysiol 2016;127:288-89) revealed that neurofeedback flash stimulation phase-locked to high-amplitude occipital alpha influences the stimulus-locked occipital alpha-band averages and the power scaling of long-range temporal correlations of alpha-band amplitude fluctuations. At first, it might seem that neurofeedback influenced critical branching alongside there being an interaction between ongoing neuronal activity and evoked responses. However, the causal relations between these neuronal Long Range Temporal Correlations, sustained attention, and any avalanche dynamics are called into question, as is the assertion of Zhigalov et al. that the neurofeedback flashes are unconsciously processed rather than capturing attention. Uncorrected concerns about false discovery rate and an objective mathematical error in the cited foundational work for the study of Zhigalov et al. are also raised. Without critical branching, an alternative set of illustrative mathematical principles offered a preliminary fit to the effects in the data, whereby neurofeedback influenced the deterministic contribution to single-trial flash-evoked event-related potentials separately from the neurofeedback flash-evoked gain in the amplitude of those oscillations. Accordingly, micro-behaviours produced by separate principles of neurofeedback-related exponential occipital oscillatory alpha gain and deterministic event-related potential generation in the model have macroscale consequences causally influencing the power-scaling of long-range temporal correlations.
Initial Results on Fuzzy Floating Point Computation for Multimedia Processors

During the recent years the market of mid low end portable systems such as PDAs or mobile digital phoneshave experimented a revolution in both selling volume and features as handheld devices incorporate Multimedia applications This fact brings to an increase in the computational demands of the devices while still having the limitation of power and energy consumptionInstruction memoization is a promising technique to helpalleviate the problem of power consumption of expensive functional units such as the floating point one Unfortunately this technique could be energy inecient for low end systems due to the additional power consumption of the relatively big tables required In this paper we present a novel way of understandingmultimedia floating point operations based on the fuzzy computation paradigm losses in the computation precision may exchange performance for negligible errors in theoutput Exploiting the implicit characteristics of media FP computation we propose a new technique called fuzzy memoization Fuzzy memoization expands the capabilities of classic memoization by attaching entries with similar inputs to the same output We present a case of study for a SH like processor and report good performance and power delay improvements with feasible hardware requirements
A Mobile IPv6 based Seamless Handoff Strategy for Integrated UMTS-WLAN Networks

It is a very important and to be worthy of research issue which eluci- dates that how to provide mobile users for roaming among different access technology networks through seamless handoff mechanism. IPv6 will play an important role in the future wireless access networks, each of equipment has its unique IP address. For mobile equipment, IPv6 have mobility support (Mobile IPv6). Therefore, in order to integrate with heterogeneous wireless networks, adopting IP backbone is the best solution. Moreover, it supports that the mobile users to roam seamlessly by Mobile IP technology. This paper proposes an in- tegrated architecture for UMTS network and IEEE802.11 WLAN. We also pro- pose a Mobile IPv6 based seamless handoff strategy for the integrated wireless networks to provide mobility management between UMTS and IEEE 802.11 WLAN for the mobile users. Moreover, we hope to contribute our researches to beyond 3G (B3G) wireless networks.
Discovery of key regulators of dark gland development and hypericin biosynthesis in St. John's Wort (Hypericum perforatum)

Summary Hypericin is a molecule of high pharmaceutical importance that is synthesized and stored in dark glands (DGs) of St. John's Wort (Hypericum perforatum). Understanding which genes are involved in dark gland development and hypericin biosynthesis is important for the development of new Hypericum extracts that are highly demanded for medical applications. We identified two transcription factors whose expression is strictly synchronized with the differentiation of DGs. We correlated the content of hypericin, pseudohypericin, endocrocin, skyrin glycosides and several flavonoids with gene expression and DG development to obtain a revised model for hypericin biosynthesis. Here, we report for the first time genotypes which are polymorphic for the presence/total absence (G+/G−) of DGs in their placental tissues (PTs). DG development was characterized in PTs using several microscopy techniques. Fourier transform infrared microscopy was established as a novel method to precisely locate polyaromatic compounds, such as hypericin, in plant tissues. In addition, we obtained transcriptome and metabolome profiles of unprecedented resolution in Hypericum. This study addresses for the first time the development of dark glands and identifies genes that constitute strong building blocks for the further elucidation of hypericin synthesis, its manipulation in plants, its engineering in microbial systems and its applications in medical research.
Maritime non-cooperative target imaging with COSMO SkyMed data

Advanced satellite SAR systems, such as Cosmo SkyMed, provide high resolution images with reasonably short revisiting time, allowing for a number of applications in areas such as Homeland Security and Maritime Surveillance. Especially in the case of maritime surveillance, non-ccoperative moving targets imaging represent a challenge for SAR systems as the complex target motions produce evident image defocusing. In the present paper, we show evidence of the effectiveness of the applications of ISAR processing to obtain well focused images of such type of targets. It will be also shown that super-resolution techniques are applicable to targets affected by complex motions after ISAR processing is used.
Effect of rutin on early diabetic neuropathy in experimental animals

The aim of the present study was to explore the effect of rutin on early diabetic neuropathy in experimental animals. Streptozotocin (55 mg/kg, i.p.) was administered to different groups of rats. Four weeks after injection of streptozotocin, rutin (50 and 100 mg/kg, p.o.), metformin (200 mg/kg, p.o.) and sertraline (30 mg/kg, p.o.) were administered in diabetic rats (n=5) for three weeks. The antidiabetic activity of rutin was studied by measuring serum glucose, serum triglyceride and glycosylated hemoglobin. Thermal hyperalgesia, formalin induced hyperalgesia, cold allodynia, walking function test, tumour necrosis factor- alpha, plasma antioxidant enzymes like SOD, NO, MDA, GSH, catalase levels and sciatic nerve axonal degeneration were performed to assess the extent of neuropathy. Four weeks after a single dose intraperitoneal injection of streptozotocin (55 mg/kg), rats exhibited significant hyperalgesia along with increased serum glucose and decreased body weights as compared with control rats. Treatment of rutin (50 and 100 mg/kg; p.o.) given for 3 weeks starting from the 4th week of streptozotocin injection significantly lowered biochemical changes and delayed paw and tail withdrawal latency in hyperalgesia and allodynia respectively. Preventive treatment of rutin significantly improved paw flinching response in formalin induced hyperalgesia. Rutin also inhibited the level of serum TNF-α. Rutin restored antioxidant enzymes NO level and SOD, GSH, CAT level activities in diabetic rats. Rutin has shown beneficial effect in preventing the progression of early diabetic neuropathy in rats.
Implementation trade-offs for linear detection in large-scale MIMO systems

In this paper, we analyze the VLSI implementation tradeoffs for linear data detection in the uplink of large-scale multiple-input multiple-output (MIMO) wireless systems. Specifically, we analyze the error incurred by using the sub-optimal, low-complexity matrix inverse proposed in Wu et al., 2013, ISCAS, and compare its performance and complexity to an exact matrix inversion algorithm. We propose a Cholesky-based reference architecture for exact matrix inversion and show corresponding implementation results on an Virtex-7 FPGA. Using this reference design, we perform a performance/complexity trade-off comparison with an FPGA implementation for the proposed approximate matrix inversion, which reveals that the inversion circuit of choice is determined by the antenna configuration (base-station antennas vs. number of users) of large-scale MIMO systems.
Multi-Input Multi-Output Deletion Channel

We describe a new channel model suitable in certain applications, namely the multi-input multi-output (MIMO) deletion channel. This channel models the scenarios where multiple transmitters and receivers suffering from synchronization errors are employed. We then consider a coding scheme over such channels based on a serial concatenation of a low-density parity check (LDPC) code, a marker code and a layered space-time code. We design two detectors operating at the bit level which jointly achieve synchronization for the deletion channel (with the help of the marker code) and detection for the MIMO channel. Utilizing the proposed detector together with an LDPC code with powerful error-correction capabilities, we demonstrate that reliable transmission over a MIMO deletion channel is feasible.
The VLBA Imaging and Polarimetry Survey at 5 GHz

We present the first results of the VLBA Imaging and Polarimetry Survey (VIPS), a 5 GHz VLBI survey of 1127 sources with flat radio spectra. Through automated data reduction and imaging routines, we have produced publicly available I, Q, and U images and have detected polarized flux density from 37% of the sources. We have also developed an algorithm to use each source's I image to automatically classify it as a pointlike source, a core jet, a compact symmetric object (CSO) candidate, or a complex source. Using data from the Sloan Digital Sky Survey (SDSS), we have found no significant trend between optical flux and 5 GHz flux density for any of the source categories. Using the velocity width of the Hβ emission line and the monochromatic luminosity at 5100 Å to estimate the central black hole mass, MBH, we have found a weak trend between MBH and 5 GHz luminosity density for objects with SDSS spectra. The mean ratio of the polarized to total 5 GHz flux density for VIPS sources with detected polarized flux density ranges from 1% to 20% with a median value of about 5%. We have also found significant evidence that the directions of the jets in core-jet systems tend to be perpendicular to the electric vector position angles (EVPAs). The data are consistent with a scenario in which ~24% of the polarized core jets have EVPAs that are antialigned with the directions of their jet components and that have a substantial amount of Faraday rotation. In addition to these initial results, plans for future follow-up observations are discussed.
The circulatory–respiratory determination of death in organ donation*

Objective:Death statutes permit physicians to declare death on the basis of irreversible cessation of circulatory–respiratory or brain functions. The growing practice of organ donation after circulatory determination of death now requires physicians to exercise greater specificity in circulatory–respiratory death determination. We studied circulatory–respiratory death determination to clarify its concept, practice, and application to innovative circulatory determination of death protocols. Results:It is ethically and legally appropriate to procure organs when permanent cessation (will not return) of circulation and respiration has occurred but before irreversible cessation (cannot return) has occurred because permanent cessation: 1) is an established medical practice standard for determining death; 2) is the meaning of “irreversible” in the Uniform Determination of Death Act; and 3) does not violate the “Dead Donor Rule. ” Conclusions:The use of unmodified extracorporeal membrane oxygenation in the circulatory determination of death donor after death is declared should be abandoned because, by restoring brain circulation, it retroactively negates the previous death determination. Modifications of extracorporeal membrane oxygenation that avoid this problem by excluding brain circulation are contrived, invasive, and, if used, should require consent of surrogates. Heart donation in circulatory determination of death is acceptable if proper standards are followed to declare donor death after establishing the permanent cessation of circulation. Pending additional data on “auto-resuscitation,” we recommend that all circulatory determination of death programs should utilize the prevailing standard of 2 to 5 mins of demonstrated mechanical asystole before declaring death.