Miracle-dz/UniFAR-FTUs huggingface dataset:
The efficacy of systemic therapy for internalizing and other disorders of childhood and adolescence: a systematic review of 38 randomized trials.

Systemic therapy (ST) is one of the most widely applied psychotherapeutic approaches in the treatment of children and adolescents, yet few systematic reviews exist on the efficacy of ST with this age group. Parallel to a similar study on adults, a systematic review was performed to analyze the efficacy of ST in the treatment of children and adolescents. All randomized or matched controlled trials (RCT) evaluating ST in any setting with child and adolescent index patients were identified by database searches and cross-references, as well as in existing meta-analyses and reviews. Inclusion criteria were: index patient diagnosed with a DSM-IV or ICD-10 listed psychological disorder, or suffering from other clinically relevant conditions, and trial published by December 2011. Studies were analyzed according to their sample, research methodology, interventions applied, and results at end-of-treatment and at follow-up. This article presents findings for internalizing and mixed disorders. Thirty-eight trials were identified, with 33 showing ST to be efficacious for the treatment of internalizing disorders (including mood disorders, eating disorders, and psychological factors in somatic illness). There is some evidence for ST being also efficacious in mixed disorders, anxiety disorders, Asperger disorder, and in cases of child neglect. Results were stable across follow-up periods of up to 5 years. Trials on the efficacy of ST for externalizing disorders are presented in a second article. There is a sound evidence base for the efficacy of ST as a treatment for internalizing disorders of child and adolescent patients.
Genetic Strategies to Detect Genes Involved in Alcoholism and Alcohol-Related Traits

Researchers are using a variety of sophisticated approaches to identify genes that contribute to the development of alcoholism in humans or influence other alcohol-related traits. These strategies include linkage approaches, which can identify broad chromosomal regions that are likely to contain genes predisposing to the disorder, and association approaches, which test the association between a particular marker allele and a specific outcome. Animal studies using diverse strategies can also help identify genes or DNA regions that influence alcohol-related traits in humans. The results of these analyses are likely to have implications for fields such as genetic counseling, gene therapy, and pharmacogenetics.
Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy.

Self-assembly properties of HIV-1 integrase were investigated by time-resolved fluorescence anisotropy using tryptophanyl residues as a probe. From simulation analyses, we show that suitable photon counting leads to an accurate determination of long rotational correlation times in the range of 20-80 ns, permitting the distinction of the monomer, dimer, and tetramer from higher oligomeric forms of integrase. The accuracy of correlation times higher than 100 ns is too low to distinguish the octamer from other larger species. The oligomeric states of the widely used detergent-solubilized integrase were then studied in solution under varying parameters known to influence the activity. In the micromolar range, integrase exists as high-order multimers such as an octamer and/or aggregates and a well-defined tetramer, at 25 and 35 degrees C, respectively. However, integrase is monomeric at catalytically active concentrations (in the sub-micromolar range). Detergents (NP-40 and CHAPS) and divalent cation cofactors (Mg(2+) and Mn(2+)) have a clear dissociative effect on the high multimeric forms of integrase. In addition, we observed that Mg(2+) and Mn(2+) have different effects on both the oligomeric state and the conformation of the monomer. This could explain in part why these two metal cations are not equivalent in terms of catalytic activity in vitro. In contrast, addition of Zn(2+) stimulates dimerization. Interestingly, this role of Zn(2+) in the multimerization process was evident only in the presence of Mg(2+) which by itself does not induce oligomerization. Finally, it is highly suggested that the presence of detergent during the purification procedure plays a negative role in the proper self-assembly of integrase. Accordingly, the accompanying paper [Leh, H. , et al. (2000) Biochemistry 39, 9285-9294] shows that a detergent-free integrase preparation has self-assembly and catalytic properties different from those of the detergent-solubilized enzyme.
Cooperative Coevolution of Morphologically Heterogeneous Robots

Morphologically heterogeneous multirobot teams have shown significant potential in many applications. While cooperative coevolutionary algorithms can be used for synthesising controllers for heterogeneous multirobot systems, they have been almost exclusively applied to morphologically homogeneous systems. In this paper, we investigate if and how cooperative coevolutionary algorithms can be used to evolve behavioural control for a morphologically heterogeneous multirobot system. Our experiments rely on a simulated task, where a ground robot with a simple sensor-actuator configuration must cooperate tightly with a more complex aerial robot to find and collect items in the environment. We first show how differences in the number and complexity of skills each robot has to learn can impair the effectiveness of cooperative coevolution. We then show how coevolution’s effectiveness can be improved using incremental evolution or novelty-driven coevolution. Despite its limitations, we show that coevolution is a viable approach for synthesising control for morphologically heterogeneous systems.
GA-based camera calibration for vision-assisted robotic assembly system

Vision sensors are employed in robotic assembly system to sense the dynamic environment and to position the manipulator precisely based on the sensor feedback. This process is termed as visual servoing. Precise calibration of the camera and camera/robot system are required to estimate the desired velocity of the robot and accurate positioning of the mating parts. In position-based visual servoing, roughly calibrated camera leads to errors in robot/camera pose identification that affects the positional accuracy and time to reach the target position. A camera calibration procedure based on genetic algorithm (GA) is proposed in this study to estimate the intrinsic and extrinsic parameters of the camera model for improving positional accuracy and faster convergence. The proposed algorithm is implemented with two-stage procedure and it comprises: determination of the camera parameters for distortion-less model and reduction of re-projection error through GA with linearly determined camera distortion-less parameters as an initial solution. The proposed camera calibration algorithm has been tested and compared with the dataset images in the literature for its performance in terms of measurement accuracy. The result shows that the proposed algorithm has the capability to calibrate the distorted images with minimum re-projection error using single image.
Perceptions of resilience of children with learning difficulties who are involved in bullying

Research has shown that bullying is associated with many negative results. Children with learning difficulties who are involved in bullying and those susceptible to victimization may be adversely affected, although environmental resilience can reduce these effects. This study used an eco-systemic approach to explore the perceptions of resilience in some children with learning difficulties who have been involved in bullying. It also aimed to better understand multiple views on the resilience of these students as perceived by parents and school staff. This qualitative study used visual methods and was implemented in a suburban and a rural elementary school with 10 students from grades 5 and 6, their parents, teachers, principals, and other support personnel. Visual storytelling, through pictures and interviews, provided access to important information on the perceptions of the resilience of these students. In addition, parents and school staff were asked to participate in semi-structured interviews to explore their perceptions of resilience in these children who have been involved in bullying. There was evidence that these children had low selfesteem and were socially blind to their actions considered by others to be bullying. However, if given the opportunity to be active, creative, and somewhat autonomous within a structured role, especially in situations that were non-evaluative or when provided with adult assistance, these children were able to access resilience more easily. The need for a special relationship within the school community was central to accessing resilience for the children in this study. Relationshipbased activities that empower children appear to be a way to foster resilience within schools, especially for at-risk students involved in bullying.
Effect of Anesthesia on Magnetic Nanoparticle Biodistribution After Intravenous Injection

The role of anesthesia on magnetic nanoparticle biodistribution among different organs after intravenous injection has been studied in a murine model. Animals were anesthetized by inhalation with isoflurane (0.5% in oxygen) or by intraperitoneal injection with a mixture of ketamine and xylazine. Then, monodisperse dimercaptosuccinic acid coated magnetic nanoparticles (diameter of 9.2 nm 1.2 nm) were administered intravenously to the animals. Lung and liver tissues were collected after the particle administration and the amount of particles in each tissue was determined by alternating current magnetic susceptibility measurements. Whereas the amount of particles that reaches the liver seems not to be affected by the anesthesia used, the amount of particles that reaches the lungs for inhaled isoflurane is three times less than for the intraperitoneally injected anesthetic.
A Domain Decomposition Finite Difference Time Domain (DD-FDTD) method for solving the scattering problem from very large rough surfaces

A Domain Decomposition Finite Difference Time Domain (DD-FDTD) method is proposed to solve the problem of electromagnetic scattering from very large rough surfaces. The coupling to the Huygens' surface above a specific subdomain from induced currents on the rough surface in adjacent subdomains is determined by using the reciprocity theorem. The normalized radar cross sections (NRCS's) obtained with the DD-FDTD method match well with those using the conventional FDTD method.
Accelerometer-based quantitative analysis of axial nocturnal movements differentiates patients with Parkinson's disease, but not high-risk individuals, from controls

Introduction There is a need for prodromal markers to diagnose Parkinson’s disease (PD) as early as possible. Knowing that most patients with overt PD have abnormal nocturnal movement patterns, we hypothesised that such changes might occur already in non-PD individuals with a potentially high risk for future development of the disease. Methods Eleven patients with early PD (Hoehn & Yahr stage ≤2.5), 13 healthy controls and 33 subjects with a high risk of developing PD (HR-PD) were investigated. HR-PD was defined by the occurrence of hyperechogenicity of the substantia nigra in combination with prodromal markers (eg, slight motor signs, olfactory dysfunction). A triaxial accelerometer was used to quantify nocturnal movements during two nights per study participant. Outcome measurements included mean acceleration, and qualitative axial movement parameters, such as duration and speed. Results Mean acceleration of nocturnal movements was lower in patients with PD compared to controls. Frequency and speed of axial movements did not differ between patients with PD and controls, but mean size and duration were lower in PD. The HR-PD group did not significantly differ from the control group in any of the parameters analysed. Conclusions Compared with controls, patients with PD had an overall decreased mean acceleration, as well as smaller and shorter nocturnal axial movements. These changes did not occur in our potential HR-PD individuals, suggesting that relevant axial movement alterations during sleep have either not developed or cannot be detected by the means applied in this at-risk cohort.
Early but not late stent thrombosis is influenced by residual platelet aggregation in patients undergoing coronary interventions.

AIMS Recent studies suggest a relevant association of post-interventional residual platelet aggregation (RPA) under therapy with oral platelet inhibitors and the occurrence of atherothrombotic events. The influence of post-interventional RPA on the incidence of stent thrombosis (ST) has not been sufficiently evaluated in consecutive unselected cohorts of percutaneous coronary intervention (PCI) patients. The aim of this observational study was to investigate the impact of RPA on the incidence of ST within 3 months in patients treated with dual antiplatelet therapy. METHODS AND RESULTS The study population included a consecutive cohort of 1019 patients treated with PCI [n = 741 bare-metal stent (BMS) and n = 278 drug-eluting stent (DES)] due to symptomatic coronary artery disease. Residual platelet activity was assessed by adenosine disphosphate (20 micromol/L)-induced PA after 600 mg clopidogrel loading dose. Maximum RPA was measured as peak of aggregation, final RPA was measured 5 min after addition of agonist. The primary endpoint was the occurrence of ST within 3 months defined according to academic research consortium (ARC) criteria. Final and maximum RPA were independent predictors of ST after 3 months. In secondary analysis, the observed effects were independently associated with early ST (HR 1.05, 95% CI 1.01-1.08 and HR 1.05, 95% CI 1.01-1.09, P < 0.01, respectively). However, incidence of 3-month late stent thrombosis (LAT) was not influenced by post-interventional RPA in multivariable analysis. CONCLUSION Post-interventional RPA is associated with the occurrence of early ST in patients treated with either BMS or DES; however, there is no predictive value of RPA for the incidence of 3-month LAT, suggesting the involvement of other possible mechanisms like discontinuation of antiplatelet therapy.
On the shape of luminosity profiles of dwarf galaxies as a distance indicator: the NGC 5044 Group revisited

Conflicting evidence has been recently raised in order to use surface brightness profiles of dwarf galaxies as a distance indicator. In this paper we discuss in some detail the main error sources in profile fitting procedures for galaxies with more than one physical component, showing their impact on the resulting shape parameters. The apparent tight coupling between shape parameter and (pseudo) scalelength in the Sersic law is especially dealt with, demonstrating that this relationship is mostly a mathematical artifact, thus throwing doubts on its usefulness as a distance indicator. Galaxies departing from the luminosity-shape relation are shown to exhibit different kinds of intrinsic peculiarities, thus prompting for better securing the empirical constraints to conform observational samples. As a relevant example in this sense, new observations of the galaxy N50 in the NGC 5044 Group are presented. We show that this object may be at an intermediate evolutionary stage between blue compact dwarfs (BCDs) and dwarf ellipticals (dEs).
Frequency error measurement in GMSK signals in a multipath propagation environment

The paper presents an efficient method for evaluating the carrier frequency in GMSK communication systems. This method operates in a nonintrusive way. It utilizes the learning vector quantisation neural network based demodulator for reconstructing the transmitted phases. From these and the expected phases is estimated the carrier frequency error. The method is able to operate both in static and multipath propagation cases and it does not require a high frequency sampling rate because the base-band signal is processed. In order to apply the method two procedures, PSP (Procedure for Static Propagation) and PMP (Procedure for Multipath Propagation), are set-up. Tests performed on GMSK signals show that the method is quite attractive, fast and more accurate if compared with other approaches.
Reduced Brain Size and Gyrification in the Brains of Dyslexic Patients

Dyslexia is a specific learning disability that affects the way in which a person acquires reading skills. The pathologic substrate of the condition has been debated in the literature. Conclusions from postmortem studies remain controversial because series have been based on few and often ill-characterized cases. The present article expands on one of the reported neuropathologic findings in dyslexia, that is, wider minicolumns. Measurements were made of magnetic resonance images in a series of 16 dyslexic and 14 age- and sex-matched controls. Dyslexic patients had significantly smaller total cerebral volume (P = .014) and reduced gyrification index (P = .021). No changes were noted in cortical thickness, the ratio of gray to white matter, or the cross-sectional areas of the corpus callosum and medulla oblongata. The findings, although not conclusive, are in keeping with a minicolumnar defect in dyslexia. The decreased gyrification and preserved cortical thickness can alter the information processing capacity of the brain by providing a greater degree of cortical integration at the expense of a slower response time. The article also emphasizes the contrast between findings in dyslexia and in autism. (J Child Neurol 2004;19:275-281).
All-optical bit-error monitoring system using cascaded inverted wavelength converter and optical NOR gate

A novel all-optical bit-error monitoring system is demonstrated by cascading two all-optical logic gates: an inverted wavelength converter and an optical NOR gate which are realized using injection-locked laser diodes operating at different thresholds. Real-time optical monitoring signal is generated which indicates the positions and duration of both bit and burst errors in 10-Gb/s nonreturn-to-zero signals.
Decrypted Result Vector Ad Reporting CloudAd 1 ... Ad 2 Adn Single Trusted 3 rd Party Server Decrypt :

We present a protocol to enable privacy preserving advertising reporting at scale. Unlike previous systems, our work scales to millions of users and tens of thousands of distinct ads. Our approach builds on the homomorphic encryption approach proposed by Adnostic [42], but uses new cryptographic proof techniques to efficiently report billions of ad impressions a day using an additively homomorphic voting schemes. Most importantly, our protocol scales without imposing high loads on trusted third parties. Finally, we investigate a cost effective method to privately deliver ads with computational private information retrieval.
Investigating politics through artistic practices: Affect resonance of creative publics

While artistic practices have been central to political movements throughout the 20th century, much analysis treats these modes of expression as distinct or separate from more traditional forms of civic practices and everyday political participation. Building on discussions of the cultural turn in civic agency and the shortcoming of cultural citizenship, the authors of this article interrogate the relationship between affect, artistic practices and participatory politics. We discuss the findings from a research project in which the researchers worked with artist-facilitators involved in a community engagement initiative around the 2015 Canadian Federal Election. The investigation made use of an innovative combination of qualitative methods including probe-based research methods to better understand how participatory artistic practices can play a role in the election cycle. Through an account of our investigation conducted with these artists, we explore the role of artistic practices and emotion in navigating the distinctions between politics and the political in everyday life.
Plant stanol esters are potentially cost-effective in the prevention of coronary heart disease in men: Bayesian modelling approach

Background Plant stanol esters in spreads have demonstrated efficacy in reducing serum cholesterol. The cost-effectiveness of plant stanol esters in the prevention of coronary heart disease, however, has remained unevaluated. Design A Bayesian modelling approach was applied to synthesize clinical evidence and evaluate the cost-effectiveness (€/quality-adjusted life years) of plant stanol esters in spread in the prevention of coronary heart disease based on published FINRISK and 4S risk functions. Results The regular use of plant stanol esters reduced total serum cholesterol by −0.362 mmol/l [95% credibility interval (CrI) −0.31 to −0.41]. The corresponding placebo-adjusted reduction attributable to stanol esters when combined with statin was −0.385 mmol/l (95% CrI −0.18 to −0.61). The cost-effectiveness estimations were assessed for men and women separately at four different initial ages at which the regular use of stanol esters was assumed to be started. The base case cost per quality-adjusted life years gained by using stanol esters regularly ranged from €7436 to €20 999 in men and from €34 327 to €112151 in women based on the initial starting age. According to uncertainty analysis, there is over a 90% probability that the use of plant stanol esters is cost-effective for men inclusively and for 60-year-old and older women assuming that decision-makers' maximum willingness to pay per quality-adjusted life year is €50000. Conclusions A recommendation that plant stanol ester-containing spreads be used as a part of daily diet replacing regular spread could be viewed as potentially cost-effective public health policy in the prevention of CHD in all adult men and in older age-groups of women with total serum cholesterol levels of 5 mmol/l or greater.
Group V Secretory Phospholipase A2 Translocates to the Phagosome after Zymosan Stimulation of Mouse Peritoneal Macrophages and Regulates Phagocytosis*

We have previously reported that group V secretory phospholipase A2 (sPLA2) amplifies the action of cytosolic phospholipase A2(cPLA2) α in regulating eicosanoid biosynthesis by mouse peritoneal macrophages stimulated with zymosan (Satake, Y., Diaz, B. L., Balestrieri, B., Lam, B. K., Kanaoka, Y., Grusby, M. J., and Arm, J. P. (2004) J. Biol. Chem. 279, 16488-16494). To further understand the role of group V sPLA2, we studied its localization in resting mouse peritoneal macrophages before and after stimulation with zymosan and the effect of deletion of the gene encoding group V sPLA2 on phagocytosis of zymosan. We report that group V sPLA2 is present in the Golgi apparatus and recycling endosome in the juxtanuclear region of resting peritoneal macrophages. Upon ingestion of zymosan by mouse peritoneal macrophages, group V sPLA2 is recruited to the phagosome. There it co-localizes with cPLA 2 α, 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase. Using immunostaining for the cysteinyl leukotrienes in carbodiimide-fixed cells, we show, for the first time, that the phagosome is a site of cysteinyl leukotriene formation. Furthermore, peritoneal macrophages from group V sPLA2-null mice demonstrated a >50% attenuation in phagocytosis of zymosan particles, which was restored by adenoviral expression of group V sPLA2 but IIA not group sPLA2. These data demonstrate that group V sPLA2 contributes to the innate immune response both through regulation of eicosanoid generation in response to a phagocytic stimulus and also as a component of the phagocytic machinery.