Miracle-dz/UniFAR-FTUs huggingface dataset:
Development and Usability of ADappt: Web-Based Tool to Support Clinicians, Patients, and Caregivers in the Diagnosis of Mild Cognitive Impairment and Alzheimer Disease

Background As a result of advances in diagnostic testing in the field of Alzheimer disease (AD), patients are diagnosed in earlier stages of the disease, for example, in the stage of mild cognitive impairment (MCI). This poses novel challenges for a clinician during the diagnostic workup with regard to diagnostic testing itself, namely, which tests are to be performed, but also on how to engage patients in this decision and how to communicate test results. As a result, tools to support decision making and improve risk communication could be valuable for clinicians and patients. Objective The aim of this study was to present the design, development, and testing of a Web-based tool for clinicians in a memory clinic setting and to ascertain whether this tool can (1) facilitate the interpretation of biomarker results in individual patients with MCI regarding their risk of progression to dementia, (2) support clinicians in communicating biomarker test results and risks to MCI patients and their caregivers, and (3) support clinicians in a process of shared decision making regarding the diagnostic workup of AD. Methods A multiphase mixed-methods approach was used. Phase 1 consisted of a qualitative needs assessment among professionals, patients, and caregivers; phase 2, consisted of an iterative process of development and the design of the tool (ADappt); and phase 3 consisted of a quantitative and qualitative assessment of usability and acceptability of ADappt. Across these phases, co-creation was realized via a user-centered qualitative approach with clinicians, patients, and caregivers. Results In phase 1, clinicians indicated the need for risk calculation tools and visual aids to communicate test results to patients. Patients and caregivers expressed their needs for more specific information on their risk for developing AD and related consequences. In phase 2, we developed the content and graphical design of ADappt encompassing 3 modules: a risk calculation tool, a risk communication tool including a summary sheet for patients and caregivers, and a conversation starter to support shared decision making regarding the diagnostic workup. In phase 3, ADappt was considered to be clear and user-friendly. Conclusions Clinicians in a memory clinic setting can use ADappt, a Web-based tool, developed using multiphase design and co-creation, for support that includes an individually tailored interpretation of biomarker test results, communication of test results and risks to patients and their caregivers, and shared decision making on diagnostic testing.
Factors influencing valproate pharmacokinetics in children and adults.

OBJECTIVE The aim of the present study was to build population pharmacokinetic models for the clearance of valproate (VPA) in 2 separate populations of Serbian patients with epilepsy, children and adults. METHODS Analysis was performed using 65 and 63 steady-state concentrations of VPA collected from 58 children and 60 adult epileptic patients, respectively. Mean values for total body weight and age were 27.07 ± 13.08 kg and 7.21 ± 3.63 years in the pediatric population, and 69.67 ± 15.60 kg and 33.97 ± 16.41 years in the adult population. The one-compartment model with first order elimination and without absorption was used from the PREDPP (Prediction for Observation Population Pharmacokinetics) library of NONMEM software. RESULTS The derived final models show that VPA clearance increased with total body weight of patients in both populations. However, the carbamazepine comedication was the main determinant of the final model in children whereas phenobarbitone comedication was the most important factor in the adult population. The magnitudes of these effects were +0.159 lh-1 and +0.539 lh-1 for carbamazepine and phenobarbitone, respectively. A significant decrease in interindividual and intraindividual variability was observed in the target populations. The pharmacokinetic models obtained were validated in groups of 15 epileptic patients, each showing good predictive performance of the model. CONCLUSIONS The derived models describe well VPA clearance in terms of characteristics of Serbian pediatric and adult epileptic patients, offering a basis for rational individualization of VPA dosage regimens.
Photoperiodism of Male Offspring Production in the Water Flea Daphnia pulex

Photoperiodism is a biological seasonal timing system utilized to regulate development and reproduction in organisms. The freshwater micro-crustacean Daphnia pulex displays environmental sex determination, the precise physiological mechanisms of which are largely unknown due to the lack of an experimental system to induce female or male offspring production by alterations of the rearing environment. We recently found that D. pulex, WTN6 strain, produces female or male offspring in response to long-day or short-day conditions, respectively. Taking advantage of this system, here we report the photoperiodic response curve for male offspring production, showing 12 hours as natural critical daylength (50% incidence of male-producing mothers), and that male offspring inducibility is highly sensitive to photoperiodic alterations. By using monochromatic light emitting diode (LED) devices, we found that the effective wavelength is red-light (627 nm), which stably induces male offspring production. This suggests that the red-light photoreceptor may be decisive in the primary step of sex determination process in this strain. Our findings provide the first insights into photoperiodism and red-light as key factors in triggering male offspring production in daphnids.
Functional integration of “undead” neurons in the olfactory system

Undead neurons may underlie the evolution of new olfactory circuits. Programmed cell death (PCD) is widespread during neurodevelopment, eliminating the surpluses of neuronal production. Using the Drosophila olfactory system, we examined the potential of cells fated to die to contribute to circuit evolution. Inhibition of PCD is sufficient to generate new cells that express neural markers and exhibit odor-evoked activity. These “undead” neurons express a subset of olfactory receptors that is enriched for relatively recent receptor duplicates and includes some normally found in different chemosensory organs and life stages. Moreover, undead neuron axons integrate into the olfactory circuitry in the brain, forming novel receptor/glomerular couplings. Comparison of homologous olfactory lineages across drosophilids reveals natural examples of fate change from death to a functional neuron. Last, we provide evidence that PCD contributes to evolutionary differences in carbon dioxide–sensing circuit formation in Drosophila and mosquitoes. These results reveal the remarkable potential of alterations in PCD patterning to evolve new neural pathways.
Using a Cluster for Securing Embedded Systems

In today's increasingly interconnected world, the deployment of an Intrusion Detection System (IDS) is becoming very important for securing embedded systems from viruses, worms, attacks, etc. But IDSs face many challenges like computational resources and ubiquitous threats. Many of these challenges can be resolved by running the IDS in a cluster to allow tasks to be parallelly executed. In this paper, we propose to secure embedded systems by using a cluster of embedded cards that can run multiple instances of an IDS in a parallel way. This proposition is now possible with the availability of new low-power single-board computers (Raspberry Pi, BeagleBoard, Cubieboard, Galileo, etc.). To test the feasibility of our proposed architecture, we run two instances of the Bro IDS on two Raspberry Pi. The results show that we can effectively run multiple instances of an IDS in a parallel way on a cluster of new low-power single-board computers to secure embedded systems.
Neural Categorization of Vibrotactile Frequency in Flutter and Vibration Stimulations: An fMRI Study

As the use of wearable haptic devices with vibrating alert features is commonplace, an understanding of the perceptual categorization of vibrotactile frequencies has become important. This understanding can be substantially enhanced by unveiling how neural activity represents vibrotactile frequency information. Using functional magnetic resonance imaging (fMRI), this study investigated categorical clustering patterns of the frequency-dependent neural activity evoked by vibrotactile stimuli with gradually changing frequencies from 20 to 200 Hz. First, a searchlight multi-voxel pattern analysis (MVPA) was used to find brain regions exhibiting neural activities associated with frequency information. We found that the contralateral postcentral gyrus (S1) and the supramarginal gyrus (SMG) carried frequency-dependent information. Next, we applied multidimensional scaling (MDS) to find low-dimensional neural representations of different frequencies obtained from the multi-voxel activity patterns within these regions. The clustering analysis on the MDS results showed that neural activity patterns of 20-100 Hz and 120-200 Hz were divided into two distinct groups. Interestingly, this neural grouping conformed to the perceptual frequency categories found in the previous behavioral studies. Our findings therefore suggest that neural activity patterns in the somatosensory cortical regions may provide a neural basis for the perceptual categorization of vibrotactile frequency.
A new acted emotional body behavior database

In this paper, we describe our new acted emotional body behavior database composed of 3D motion capture data as well as syn- chronized video. The movements of 11 actors (6 female and 5 male) were captured while they expressed 8 emotional states (Joy, Anger, Panic Fear, Anxiety, Sadness, Shame, Pride and Neutral) described with 3 scenarios and performed through 7 dierent actions (Knocking at a door, walking, walking with an object in the hands, sitting down, lifting, throwing and moving objects on a table). Each action was performed several times to capture a wide range of data.
Effect of speed endurance training and reduced training volume on running economy and single muscle fiber adaptations in trained runners

The aim of the present study was to examine whether improved running economy with a period of speed endurance training and reduced training volume could be related to adaptations in specific muscle fibers. Twenty trained male (n = 14) and female (n = 6) runners (maximum oxygen consumption (VO2‐max): 56.4 ± 4.6 mL/min/kg) completed a 40‐day intervention with 10 sessions of speed endurance training (5–10 × 30‐sec maximal running) and a reduced (36%) volume of training. Before and after the intervention, a muscle biopsy was obtained at rest, and an incremental running test to exhaustion was performed. In addition, running at 60% vVO2‐max, and a 10‐km run was performed in a normal and a muscle slow twitch (ST) glycogen‐depleted condition. After compared to before the intervention, expression of mitochondrial uncoupling protein 3 (UCP3) was lower (P < 0.05) and dystrophin was higher (P < 0.05) in ST muscle fibers, and sarcoplasmic reticulum calcium ATPase 1 (SERCA1) was lower (P < 0.05) in fast twitch muscle fibers. Running economy at 60% vVO2‐max (11.6 ± 0.2 km/h) and at v10‐km (13.7 ± 0.3 km/h) was ~2% better (P < 0.05) after the intervention in the normal condition, but unchanged in the ST glycogen‐depleted condition. Ten kilometer performance was improved (P < 0.01) by 3.2% (43.7 ± 1.0 vs. 45.2 ± 1.2 min) and 3.9% (45.8 ± 1.2 vs. 47.7 ± 1.3 min) in the normal and the ST glycogen‐depleted condition, respectively. VO2‐max was the same, but vVO2‐max was 2.0% higher (P < 0.05; 19.3 ± 0.3 vs. 18.9 ± 0.3 km/h) after than before the intervention. Thus, improved running economy with intense training may be related to changes in expression of proteins linked to energy consuming processes in primarily ST muscle fibers.
Disturbances in myocardial creatine kinase following ethanol administration to rats--trials of prevention by allopurinol, desferrioxamine and propranolol.

A significant decrease in myocardial creatine kinase (CK) activity is apparent 2 hr after an acute ethanol load (2.3 g/kg, i.p.) in the rat. A lower dose (1.15 g/kg, i.p.), as well as ethanol addition in vitro up to 50 mM, do not affect this activity. Pretreatment with allopurinol (146 mumols/kg, i.p.) given at 16 hr and at 30 min before ethanol (2.3 g/kg) or with desferrioxamine (152 mumols/kg, i.p.) 30 min before ethanol failed to prevent the ethanol-induced decrease in CK activity. By contrast, propranolol (17 mumols/kg, i.p.), administered 30 min before ethanol elicited an enhanced CK activity in both control and ethanol-treated rats. This finding is likely related to the beta-blocking action and/or antioxidant properties of propranolol. Chronic ethanol intake (18% in calories) for 4 weeks also induced a decrease in myocardial CK activity, which could play a role in the pathogenesis of alcoholic cardiomyopathy.
Partial and complete ruptures of the Achilles tendon and local corticosteroid injections.

ontherheumatoid joint'. This wonthemtheNobelprize formedicine in1950. Unfortunately, thesideeffects ofintramuscular injections ofcortisone wereimportant anditwasnot until1951thatHollander etal.elucidated how steroids couldbeusedlocally withreduction of systemic sideeffects2. Theyshowedthathydrocortisoneinjected locally wasmuchmoreeffective than cortisone in suppressing synovial inflammation, confirming Mason's hypothesis thathydrocortisone rather thancortisone wastheprincipal corticoid with anti-inflammatory activity attissue level3.
Helping Norms in Relation to Religious Affiliation

Abstract The authors used vignettes to solicit each participant's estimate of the likelihood of help and his/her recommendation for or against helping a student who needed to borrow another student's class notes. The study had a 2 (Hindu vs. Muslim participant) x 2 (participant's gender) x 2 (liking vs. disliking relationship) x 2 (justified vs. unjustified need for help) x 2 (low vs. high cost of helping) factorial design with 15 participants per cell. Estimated likelihood of help was higher among the female than among the male participants, with the liking than with the disliking relationship, and with the low rather than with the high cost of helping. The Hindu participants gave lower estimates of the likelihood of help than did the Muslim participants with the disliking relationship and with the unjustified need for help. Intracommunal helping, irrespective of contextual variations, may have been a stronger social norm for the Muslim than for the Hindu participants, probably because of the former's minority status in India and, more important, the Islamic prescription of communal brotherhood. Even though both communities are deemed collectivist, the Indian Muslim participants' helping norms appeared to be more obligation oriented and less option oriented than those of the Indian Hindu participants.
Flexibility is not always adaptive: Affective flexibility and inflexibility predict rumination use in everyday life

The present study examined whether cognitive flexibility in the processing of emotional material (i.e., affective flexibility) predicts the use of rumination in response to negative events in daily life. One hundred fifty-seven undergraduate participants completed daily diaries for six consecutive days. Affective flexibility was measured with a novel task-switching paradigm using emotional pictures. Results show that affective inflexibility when switching away from processing the emotional meaning of negative material was associated with increased use of rumination in daily life. In contrast, affective inflexibility when switching away from processing the emotional meaning of positive material was related to decreased use of rumination. Importantly, affective flexibility predicted use of rumination beyond non-affective measures of executive functioning. This is the first study to show that inflexibility is not uniformly associated with increased rumination but that inflexibility in the processing of positive material can predict lower levels of rumination.
In vivo performance of an acellular disc‐like angle ply structure (DAPS) for total disc replacement in a small animal model

Total intervertebral disc replacement with a biologic engineered disc may be an alternative to spinal fusion for treating end‐stage disc disease. In previous work, we developed disc‐like angle ply structures (DAPS) that replicate the structure and function of the native disc and a rat tail model to evaluate DAPS in vivo. Here, we evaluated a strategy in which, after in vivo implantation, endogenous cells could colonize the acellular DAPS and form an extracellular matrix organized by the DAPS topographical template. To do so, acellular DAPS were implanted into the caudal spines of rats and evaluated over 12 weeks by mechanical testing, histology, and microcomputed tomography. An external fixation device was used to stabilize the implant site and various control groups were included to evaluate the effect of immobilization. There was robust tissue formation within the DAPS after implantation and compressive mechanical properties of the implant matched that of the native motion segment. Immobilization provided a stable site for fibrous tissue formation after either a discectomy or a DAPS implantation, but bony fusion eventually resulted, with segments showing intervertebral bridging after long‐term implantation, a process that was accelerated by the implanted DAPS. Thus, while compressive mechanical properties were replicated after DAPS implantation, methods to actively prevent fusion must be developed. Future work will focus on limiting fusion by remobilizing the motion segment after a period of integration, delivering pro‐chondrogenic factors, and pre‐seeding DAPS with cells prior to implantation. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:23–31, 2017.
Weak Ties Based Recommendation for Interdisciplinary Research Collaboration

This study investigates recommendations for interdisciplinary research collaboration based on the weak ties theory. Contents-based features are proposed to recommend interdisciplinary collaboration considering that some researchers who have shown a preference for interdisciplinary collaboration could be connected even if they have dissimilar research profiles. Therefore, we inferred the preference of interdisciplinary research collaboration for every researcher, and considered features such as highlighting dissimilar researchers depending on their preferences. The features are designed to have typical similarity measures when the researchers do not prefer interdisciplinary research collaboration. We evaluated our proposed features with the baseline features of patent application datasets and the former methods outperformed the latter methods.
High-Level Resistance to 3′-Azido-3′-Deoxythimidine due to a Deletion in the Reverse Transcriptase Gene of Human Immunodeficiency Virus Type 1

ABSTRACT A variant of human immunodeficiency virus type 1 (HIV-1) possessing a deletion in the reverse transcriptase (RT) gene at codon 67 was identified in a patient who had failed combination antiretroviral therapy. This deletion initially emerged under the selective pressure of combination therapy with 3′-azido-3′-deoxythymidine (AZT) plus 2′,3′-dideoxyinosine. It has persisted for more than 3 years in association with the accumulation of a variety of other well-described drug resistance mutations and an uncharacterized mutation at RT codon 69 (T69G). Phenotypic studies demonstrated that the codon 67 deletion by itself had little effect on AZT sensitivity. However, in the context of the T69G mutation and three other mutations known to be associated with AZT resistance (K70R, T215F, and K219Q), this deletion led to a increase in AZT resistance from 8.5-fold to 445-fold. A further increase in resistance (up to 1,813-fold) was observed when two mutations associated with nonnucleoside RT inhibitor resistance (K103N and L74I) were added to the deletion T69G K70R T215F K219Q construct. Hence, these results establish that a deletion at RT codon 67 may be selected for in the presence of antiretroviral therapy and may lead to high-level resistance to AZT.
A 6DOF Gravity Compensation Scheme for a Phantom Premium Using a Neural Network

Current uses of haptic hardware such as the Phantom Premium 6DOF for surgical simulators lack the desired interface transparency and could cause artefacts in the training regime of a student training on a simulator. This problem is addressed and two neural networks are used to find a mapping between handle coordinates and orientation and force output required to counteract gravitational forces. A close fit to the data is achieved for both networks (errors of 0.00149 and 0.0157 between training and predicted forces) and 3DOF gravity compensation is achieved. A 6DOF simulator is created but requires further work to improve it accuracy.
Toxicity profile and treatment delays in NOPHO ALL2008—comparing adults and children with Philadelphia chromosome‐negative acute lymphoblastic leukemia

Cure rates improve when adolescents and young adults with acute lymphoblastic leukemia (ALL) are treated according to pediatric protocols. Assumed risks of toxicities and associated delays in treatment have played a role in setting upper age limits. The aim of this study was to examine the toxicity profile and treatment delays in NOPHO ALL2008 comparing children and adults.
Quantification of the effect of flowrate on the rates of arrival and attachment to glass of Pseudomonas aeruginosa

Abstract Sets of time lapse sequences (movies) of pseudomonad cells attaching in each of six flowcells operated at Reynolds numbers from 96 – 2220 were obtained over a 3-d period. The interval between images varied between 1 s and 24 min, which allowed a range of different cell behaviours to be observed. The rate of accumulation of the cells on the surface was determined for each flowrate. Analysis of the images showed that the residence time distributions of the attaching cells were of the same form as those recorded previously in the literature. This showed that up to 50% of the cells that arrived sufficiently close to the surface to be considered temporarily attached, left the surface within 1 s of arrival. Use of an analytically derived algorithm allowed the rate of arrival of the cells to be estimated. Data showed that for every cell attaching on a relatively permanent basis, between 20 and 35 cells arrived at the surface.