Miracle-dz/UniFAR-FTUs huggingface dataset:
Attachment style, affective loss and gray matter volume: A voxel‐based morphometry study

Early patterns of infant attachment have been shown to be an important influence on adult social behavior. Animal studies suggest that patterns of early attachment influence brain development, contributing to permanent alterations in neural structure; however, there are no previous studies investigating whether differences in attachment style are associated with differences in brain structure in humans. In this study, we used Magnetic Resonance Imaging (MRI) and voxel‐based morphometry (VBM) to examine for the first time the association between attachment style, affective loss (for example, death of a loved one) and gray matter volume in a healthy sample of adults (n = 32). Attachment style was assessed on two dimensions (anxious and avoidant) using the ECR‐Revised questionnaire. High attachment‐related anxiety was associated with decreased gray matter in the anterior temporal pole and increased gray matter in the left lateral orbital gyrus. A greater number of affective losses was associated with increased gray matter volume in the cerebellum; in this region, however, the impact of affective losses was significantly moderated by the level of attachment‐related avoidance. These findings indicate that differences in attachment style are associated with differences in the neural structure of regions implicated in emotion regulation. It is hypothesized that early attachment experience may contribute to structural brain differences associated with attachment style in adulthood; furthermore, these findings point to a neuronal mechanism through which attachment style may mediate individual differences in responses to affective loss. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
Survey of mistakes made by recent veterinary graduates

To investigate the incidence and types of mistakes made in veterinary practice, and to assess the impact the mistakes had on the veterinarians involved, a questionnaire was sent in November 2002 to all the veterinary graduates of the Universities of Bristol, Edinburgh, Glasgow, London and Liverpool in 2001. One hundred and eight (27 per cent) of 402 questionnaires were returned completed; 87 of 106 respondents (82 per cent) worked frequently or always unsupervised and only 46 (43 per cent) could always rely on support from other veterinarians in the practice. Since starting work, 82 of 105 respondents (78 per cent) stated that they had made a mistake, defined as an erroneous act or omission resulting in a less than optimal or potentially adverse outcome for a patient, and in many cases these mistakes had had a considerable emotional impact on the veterinarians involved. The survey highlights that a large number of recently graduated veterinarians work with little supervision and that many veterinarians beginning their year in practice do not always have access to assistance from other veterinary colleagues.
Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees

Significance Contributions of rare variants to common and complex traits such as type 2 diabetes (T2D) are difficult to measure. This paper describes our results from deep whole-genome analysis of large Mexican-American pedigrees to understand the role of rare-sequence variations in T2D and related traits through enriched allele counts in pedigrees. Our study design was well-powered to detect association of rare variants if rare variants with large effects collectively accounted for large portions of risk variability, but our results did not identify such variants in this sample. We further quantified the contributions of common and rare variants in gene expression profiles and concluded that rare expression quantitative trait loci explain a substantive, but minor, portion of expression heritability. A major challenge in evaluating the contribution of rare variants to complex disease is identifying enough copies of the rare alleles to permit informative statistical analysis. To investigate the contribution of rare variants to the risk of type 2 diabetes (T2D) and related traits, we performed deep whole-genome analysis of 1,034 members of 20 large Mexican-American families with high prevalence of T2D. If rare variants of large effect accounted for much of the diabetes risk in these families, our experiment was powered to detect association. Using gene expression data on 21,677 transcripts for 643 pedigree members, we identified evidence for large-effect rare-variant cis-expression quantitative trait loci that could not be detected in population studies, validating our approach. However, we did not identify any rare variants of large effect associated with T2D, or the related traits of fasting glucose and insulin, suggesting that large-effect rare variants account for only a modest fraction of the genetic risk of these traits in this sample of families. Reliable identification of large-effect rare variants will require larger samples of extended pedigrees or different study designs that further enrich for such variants.
Packet Loss Recovery Scheme with Uniquely-Decodable Codes for Streaming Multimedia over P2P Networks

This paper presents an effective packet loss recovery scheme for Internet Protocol (IP) based peer-to-pear (P2P) networks that deliver multimedia streaming contents. The proposed scheme consists of two key components, a packet forward error correction (FEC) scheme and a uniquely decodable coding (UDC) scheme. The FEC scheme is devised to recover network packet loss over the transport layer to improve link transmission reliability at the user-ends of the P2P networks. The UDC scheme is employed to allow multiple sources to transmit data streams simultaneously in such a way that the combined data streams can be separated uniquely without ambiguity at the user-ends. This simultaneous multiple sources data transmission increases the throughput at the user-ends. Theoretical analysis and computer simulations show that the proposed scheme can achieve the commonly acceptable of 10^{-6} end-to-end packet loss rate for input packet loss rate of up to 10%with a reasonably small bandwidth expansion factor, while maintains a high throughput at the user-ends.
A New Density-Based Scheme for Clustering Based on Genetic Algorithm

Density-based clustering can identify arbitrary data shapes and noises. Achieving good clustering performance necessitates regulating the appropriate parameters in the density-based clustering. To select suitable parameters successfully, this study proposes an interactive idea called GADAC to choose suitable parameters and accept the diverse radii for clustering. Adopting the diverse radii is the original idea employed to the density-based clustering, where the radii can be adjusted by the genetic algorithmto cover the clusters more accurately. Experimental results demonstrate that the noise and all clusters in any data shapes can be identified precisely in the proposed scheme. Additionally, the shape covering in the proposed scheme is more accurate than that in DBSCAN.
Extracellular volume with bolus‐only technique in amyloidosis patients: Diagnostic accuracy, correlation with other clinical cardiac measures, and ability to track changes in amyloid load over time

Extracellular volume (ECV) by T1 mapping requires the contrast agent distribution to be at equilibrium. This can be achieved either definitively with a primed contrast infusion (infusion ECV), or sufficiently with a delay postbolus (bolus‐only ECV). For large ECV, the bolus‐only approach measures higher than the infusion ECV, causing some uncertainty in diseases such as amyloidosis.
Options for a second-line antiretroviral regimen for HIV type 1-infected patients whose initial regimen of a fixed-dose combination of stavudine, lamivudine, and nevirapine fails.

BACKGROUND A fixed-dose combination of stavudine, lamivudine, and nevirapine is extensively used as an antiretroviral regimen in developing countries because of its affordability. Virological failure with this regimen has become more common, and a second-line regimen needs to be prepared in the national program. METHODS Genotypic resistance testing was conducted among human immunodeficiency virus type 1 (HIV-1)-infected patients who experienced treatment failure with their first antiretroviral regimen (a fixed-dose combination of stavudine, lamivudine, and nevirapine) during 2003-2005. Patterns of resistance mutations and options for a second-line regimen were studied. RESULTS We studied 98 patients (mean age, 35.2 years), of whom, 63% were male. The median duration of antiretroviral therapy was 20 months. The median HIV-1 RNA load at the time of virological failure detection was 4.1 log copies/mL. The prevalences of patients with > or =1 major mutation conferring drug resistance to nucleoside reverse-transcriptase inhibitors and nonnucleoside reverse-transcriptase inhibitors were 95% and 92%, respectively. M184V was the most common nucleoside reverse-transcriptase inhibitor resistance mutation (observed in 89% of patients). Thymidine analogue mutations, K65R, and Q151M were observed in 37%, 6%, and 8% of patients, respectively. Patients with an HIV-1 RNA load of >4 log copies/mL at the time of treatment failure had higher prevalence of thymidine analogue mutations (P=.041), K65R (P=.031), and Q151M (P=.008) mutations. The second-line regimen was determined in a resource-limited setting where tenofovir and enfuvirtide are not available; the options were limited for 48% of patients. CONCLUSIONS After experiencing treatment failure with a fixed-dose combination of stavudine, lamivudine, and nevirapine, almost all patients have lamivudine and nonnucleoside reverse-transcriptase inhibitor resistance. The options for a second-line regimen are limited for one-half of these patients. In resource-limited settings where availability of antiretroviral agents is limited, strategies for prevention of HIV-1 resistance are crucial. Early detection of virological failure may provide more options and better treatment outcomes.
First-principles calculations of elastic properties of Cu-Sn crystalline phases

Elastic properties of a solid are closely related to many fundamental solid-state properties. Theoretical calculations on elastic constants are well motivated by the advance in computational technologies, especially when mechanical testing on submicron components is extremely difficult. Elastic constants of a number of anisotropic lattice systems have been calculated based on the density functional theory, and good agreements between computational and experimental results have been found. In this study, we report elastic properties of the Cu-Sn crystalline phases, the epsiv-Cu3Sn and eta-Cu6Sn5, using first-principles calculations. The polycrystalline moduli obtained using the Voigt-Reuss scheme are 134.16 GPa for Cu3Sn and 125.98 GPa for Cu6Sn5. The calculation results show these Cu- Sn crystalline phases have the greatest stiffness along the c direction. In particular, the results reveal the unique anisotropic feature along a and b directions within the Cu3Sn superstructure, which cannot be resolved from experiments. Our results also suggest that the least stiffness in the long-period direction is associated with the lattice modulation within the Cu3Sn superstructure.
Dynamic expression patterns of Pax6 during spermatogenesis in the mouse

Spermatogenesis is a series of complex processes to generate mature sperm, and various molecules play crucial roles in regulating these processes. Previous studies imply a possibility that a transcriptional factor Pax6, a key player of brain and sensory organ development, could be involved in spermatogenesis, but neither expression nor function of Pax6 in the adult testis has been examined yet. In the present study, we described for the first time Pax6 expression dynamics in the adult mouse testis. Using cell‐type‐specific markers, the expression of Pax6 was detected in 67.0% of promyelocytic leukemia zinc finger (Plzf)‐positive type A spermatogonia. The expression of Pax6 was also observed in p63‐positive spermatocytes and round spermatids. We did not detect any expression of Pax6 in Sox9‐positive Sertoli cells or in elongated spermatids and mature sperm. High‐resolution analyses revealed that Pax6 formed a single dot‐like structure during mid‐phase of the pachytene spermatocyte. This dot‐like structure co‐localized with γH2A. X demarcating XY body, a domain in which X and Y chromosomes are silenced and compartmentalized. These results may suggest a novel role of Pax6 in spermatogenesis.
Complete mitochondrial genome of the endemic South Korean species Odontobutis interrupta (Perciformes, Odontobutidae)

Abstract The complete mitochondrial genome of Odontobutis interrupta (Perciformes, Odontobutidae), a species endemic to South Korea, is reported here for the first time. The O. interrupta mitogenome is 16 802 base pairs in total length and includes 13 PCGs, small and large rRNAs, a control region and 22 tRNAs. Nine genes are encoded on the light strand and 29 on the heavy strand. The O. interrupta mitochondrial genome has a conserved gene order compared to four other Odontobutis species and Micropercops swinhonis, a closely related species. The data will provide useful molecular information for phylogenetic studies concerning Odontobutidae and its related species.
A Broad‐Host‐Range Vibriophage, KVP40, Isolated from Sea Water

A broad‐host‐range vibriophage, KVP40, was isolated from sea water by using Vibrio parahaemolyticus 1010 (EB101) as the indicator host. The host range of KVP40 extended over at least 8 Vibrio and 1 Photobacterium species. KVP40 was a large tailed phage containing double‐stranded DNA and belonged to Ackermann's morphotype A2. KVP40 DNA was cleaved by 11 different type II restriction endo‐nucleases including EcoRl and Hindlll, but not by 17 other enzymes including BamHI, KpnI and SalI.1
Neurological outcomes in children with and without amalgam-related mercury exposure: seven years of longitudinal observations in a randomized trial.

BACKGROUND Although large-scale, randomized trials involving children have been completed and their results demonstrate an absence of neurobehavioral effects from clinical exposure to mercury amalgam, neurological findings from such studies have not been reported. METHODS The authors conducted a randomized, prospective trial examining the safety of dental amalgam in which 507 children aged 8 through 12 years were assigned to treatment with either amalgam or resin-based composite. During seven years of follow-up, the authors performed annual clinical neurological examinations, including an evaluation of neurological hard signs (NHSs), presence of tremor and neurological soft signs (NSSs). RESULTS The authors found no significant differences between treatment groups in any of the neurological measures. Groups did not differ with respect to the presence or absence of NHSs or tremor, nor the presence or absence or severity of NSSs at any point. As expected, NSS severity scores diminished with increasing age. CONCLUSIONS Even at the levels of amalgam exposure in this study (a mean of 7.7-10.7 amalgam surfaces per subject across the seven years of follow-up), the authors conclude that exposure to mercury from dental amalgam does not adversely affect neurological status. CLINICAL IMPLICATIONS The current evidence is that potential neurobehavioral or neurological effects from dental amalgam mercury exposure in children are inconsequential.
A Model to Estimate the Composite Index of Economic Activity in Romania – IEF-RO

One of the most significant impediments for short-term forecasts is the frequency of publishing GDP. At present, national institutes of statistics are publishing officially registered GDP only quarterly. In our study, we tried to build a composite indicator based on usually monthly data and to use it in order to obtain short-term forecasts for economic activity at national level. This indicator could be useful taking into account that actually there is no synthetic indicator to describe the short-run dynamics of economic activity. Thus, such an estimating model we are proposing for the Romanian economy is coming from the last results in this field, especially from the OECD methodology. Moreover, to validate the main hypotheses of the estimating model for the composite indicator in the case of the Romanian economy we used the quarterly data and, as benchmark indicator was considered the quarterly published GDP. Using certain models based on composite indicators (leading indicators, coincidence indicators, and post-cycle indicators), beside other models to analyse high frequency time series and to obtain sort-term forecasts (such as principal component method, so-called virtual monthly GDP method or various interpolating methods), it can result in richer information for the business environment which in modern times founds itself in an accelerated process of change.
Performance measurement system design

The importance of performance measurement has long been recognized by academics and practitioners from a variety of functional disciplines. Seeks to bring together this diverse body of knowledge into a coherent whole. To ensure that the key issues are identified, focuses on the process of performance measurement system design, rather than the detail of specific measures. Following a comprehensive review of the literature, proposes a research agenda.
Expanded endonasal endoscopic resection of anterior fossa meningiomas: report of 13 cases and meta-analysis of the literature.

OBJECT Transnasal endoscopic (TNE) approaches have been proposed for the resection of anterior cranial base meningiomas. The purpose of this article was to evaluate the results of endoscopic resection of anterior cranial fossa meningiomas by reviewing available published data in addition to the authors' experience with 13 cases. METHODS The literature was searched via OVID to identify all available disaggregate data pertaining to anterior fossa meningiomas treated primarily by TNE. In addition, the authors reviewed the records of a personal series of 13 patients who underwent TNE removal of parasellar meningiomas through a pure TNE approach. RESULTS Meta-analysis from studies included a total of 69 patients with adequate disaggregated data to summarize. Mean age (± SD) at surgery was 53.3 ± 13.0 years (range 27-80 years); 78% of the patients were women. Tumor size was skewed toward smaller lesions, with a mean volume of 24.4 ± 2.9 cm(3). Intraoperative impressions were of gross-total resection in 76% of cases. The most common complication reported was CSF leakage, occurring in 32% of the cases (22 of 69). The rate of CSF leakage was not affected by size (p = 0.52), location of tumor (p = 0.9), or age (p = 0.56). There was 1 death overall. The mean duration of follow-up was 21 ± 18 months. CONCLUSIONS Transnasal endoscopic resection of anterior cranial base meningiomas is feasible in selected cases. Reported resection rates are adequate, although the follow-up in the reported series is too short (mean 21 months) to make definitive conclusions regarding the long-term effectiveness. Cerebrospinal fluid leakage is a common complication, although it appears not to be associated with additional morbidity except for the need for reoperation. Long-term results are necessary before considering TNE resection as a valid alternative, in selected cases, to the more established transcranial techniques.
Psychometric evaluation of the Snaith–Hamilton pleasure scale in adult outpatients with major depressive disorder

The inability to experience pleasure, anhedonia, is recognized as a hallmark symptom of depression. An instrument developed for the assessment of hedonic capacity is the 14-item, self-report, Snaith–Hamilton Pleasure Scale (SHAPS), but its psychometric properties have not been adequately evaluated. This study examined the reliability and validity of the SHAPS using a large sample of adult outpatients with major depressive disorder (MDD). Data for this study were obtained from 461 adult outpatients with a diagnosis of MDD who participated in Implementation of Algorithms using Computerized Treatment Systems Project. Internal consistency of the SHAPS was assessed using the Cronbach's coefficient α. A principal factor analysis was used to define the dimensionality of the SHAPS. Convergent and discriminant validity was assessed by evaluating the Pearson correlations between the SHAPS total score and the pleasure/enjoyment item of the 30-item Inventory of Depressive Symptomatology – Clinician-rating (IDS-C30); Quality of Life, Enjoyment, and Satisfaction Questionnaire; 17-item Hamilton Rating Scale for Depression; IDS-C30; 16-item Quick Inventory of Depressive Symptomatology; and 10-item clinician-rated Montgomery-Asberg Depression Rating Scale, respectively. The internal consistency of the SHAPS was 0.91. A one-factor solution emerged for the SHAPS (eigen-values of the first two initial factors were 5.95 and 0.43, respectively). Pearson correlations revealed a positive linear relationship between the SHAPS total score and the total scores on the 17-item Hamilton Rating Scale for Depression (r=0.49, P<0.0001), IDS-C30 (r=0.56, P<0.0001), 16-item Quick Inventory of Depressive Symptomatology (r=0.55, P<0.0001), and 10-item clinician-rated Montgomery-Asberg Depression Rating Scale (r=0.53, P<0.0001). The SHAPS total score was negatively correlated with the Quality of Life, Enjoyment, and Satisfaction Questionnaire (r=−0.65, P<0.0001). This study shows that the SHAPS is a reliable, valid, and unidimensional instrument used to assess the hedonic capacity in adult outpatients with MDD.
Fast Compilation of s-t Paths on a Graph for Counting and Enumeration

In this paper, we propose a new method to compile s-t simple paths on a graph using a new compilation method called merging frontier based search. Recently, Nishino et al. proposed a topdown construction algorithm, which compiles s-t simple paths into a Zero-suppressed SDD (ZSDD), and they showed that this method is more efficient than simpath by Knuth. However, since the method of Nishino et al. uses ZSDD as a tractable representation, it requires complicated steps for compilation. In this paper, we propose z-st-d-DNNF, which is a super set of ZSDD. By using this method instead of ZSDD, we show that more efficient s-t simple paths compilation can be realized.
Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss–Driven Tumorigenesis

Inactivation of NF2/Merlin causes the autosomal-dominant cancer predisposition syndrome familial neurofibromatosis type 2 (NF2) and contributes to the development of malignant pleural mesothelioma (MPM). To develop a targeted therapy for NF2-mutant tumors, we have exploited the recent realization that Merlin loss drives tumorigenesis by activating the E3 ubiquitin ligase CRL4DCAF1, thereby inhibiting the Hippo pathway component Lats. Here, we show that MLN4924, a NEDD8-activating enzyme (NAE) inhibitor, suppresses CRL4DCAF1 and attenuates activation of YAP in NF2-mutant tumor cells. In addition, MLN4924 sensitizes MPM to traditional chemotherapy, presumably as a result of collateral inhibition of cullin-RING ubiquitin ligases (CRL) involved in DNA repair. However, even in combination with chemotherapy, MLN4924 does not exhibit significant preclinical activity. Further analysis revealed that depletion of DCAF1 or treatment with MLN4924 does not affect mTOR hyperactivation in NF2-mutant tumor cells, suggesting that loss of Merlin activates mTOR independently of CRL4DCAF1. Intriguingly, combining MLN4924 with the mTOR/PI3K inhibitor GDC-0980 suppresses the growth of NF2-mutant tumor cells in vitro as well as in mouse and patient-derived xenografts. These results provide preclinical rationale for the use of NAE inhibitors in combination with mTOR/PI3K inhibitors in NF2-mutant tumors. Mol Cancer Ther; 16(8); 1693–704. ©2017 AACR.