Miracle-dz/UniFAR-FTUs huggingface dataset:
Building task-specific interfaces to high volume conversational data

As people participate in the thousands of global conversations that comprise Usenet news, one thing they do is post their opinions of web resources. Phoaks is a collaborative filtering system that continuously parses, classifies, abstracts and tallies those opinions. About 3,500 users per day consult Phoaks web pages that reflect the results. Phoaks also features a general architecture for building similar collaborative filtering interfaces to conversational data. We report here on the Phoaks resource recommendation interface, the architecture, and the issues and experience that make up its rationale.
Patterns of Nucleotide Diversity at the Regions Encompassing the Drosophila Insulin-Like Peptide (dilp) Genes: Demography vs. Positive Selection in Drosophila melanogaster

In Drosophila, the insulin-signaling pathway controls some life history traits, such as fertility and lifespan, and it is considered to be the main metabolic pathway involved in establishing adult body size. Several observations concerning variation in body size in the Drosophila genus are suggestive of its adaptive character. Genes encoding proteins in this pathway are, therefore, good candidates to have experienced adaptive changes and to reveal the footprint of positive selection. The Drosophila insulin-like peptides (DILPs) are the ligands that trigger the insulin-signaling cascade. In Drosophila melanogaster, there are several peptides that are structurally similar to the single mammalian insulin peptide. The footprint of recent adaptive changes on nucleotide variation can be unveiled through the analysis of polymorphism and divergence. With this aim, we have surveyed nucleotide sequence variation at the dilp1-7 genes in a natural population of D. melanogaster. The comparison of polymorphism in D. melanogaster and divergence from D. simulans at different functional classes of the dilp genes provided no evidence of adaptive protein evolution after the split of the D. melanogaster and D. simulans lineages. However, our survey of polymorphism at the dilp gene regions of D. melanogaster has provided some evidence for the action of positive selection at or near these genes. The regions encompassing the dilp1-4 genes and the dilp6 gene stand out as likely affected by recent adaptive events.
Study of Package-on-Package solder joints under random vibration load based on Patran

The 3D finite element analysis model of Package-on-Package solder joints was set up based on Patran software. The natural frequency, vibration mode of the model was analyzed under the condition of random vibration, the stress and strain distribution and the strain power spectrum density of response curves of the Package-on-Package solder joints were obtained, and the random vibration fatigue life of the Package-on-Package solder joints were also calculated out based on the power spectrum and rain flow count method; the influence of pad diameter on the random vibration fatigue life of the Package-on-Package solder joints were analyzed. The results show that the Package-on-Package solder joints of the model in this paper has the random vibration fatigue life of 997 hours; on the condition of the pad diameter of the second-layer solder joints increases from 0.15 mm to 0.30mm, the Package-on-Package solder joints vibration fatigue life increases with the increase of the pad diameter.
Oxygen Saturation during Electroconvulsive Therapy

Oxygen saturation was measured during anaesthesia and electroconvulsive therapy (ECT) using ear oximetry. Significant hypoxia occurred during some treatments; desaturation related to the number of ventilations performed after muscle relaxation and prior to the shock. Desaturation did not correlate significantly with seizure duration. These findings highlight the need for adequate oxygenation during ECT.
Pathogen-Associated Molecular Patterns Induced Crosstalk between Dendritic Cells, T Helper Cells, and Natural Killer Helper Cells Can Improve Dendritic Cell Vaccination

A coordinated cellular interplay is of crucial importance in both host defense against pathogens and malignantly transformed cells. The various interactions of Dendritic Cells (DC), Natural Killer (NK) cells, and T helper (Th) cells can be influenced by a variety of pathogen-associated molecular patterns (PAMPs) and will lead to enhanced CD8+ effector T cell responses. Specific Pattern Recognition Receptor (PRR) triggering during maturation enables DC to enhance Th1 as well as NK helper cell responses. This effect is correlated with the amount of IL-12p70 released by DC. Activated NK cells are able to amplify the proinflammatory cytokine profile of DC via the release of IFN-γ. The knowledge on how PAMP recognition can modulate the DC is of importance for the design and definition of appropriate therapeutic cancer vaccines. In this review we will discuss the potential role of specific PAMP-matured DC in optimizing therapeutic DC-based vaccines, as some of these DC are efficiently activating Th1, NK cells, and cytotoxic T cells. Moreover, to optimize these vaccines, also the inhibitory effects of tumor-derived suppressive factors, for example, on the NK-DC crosstalk, should be taken into account. Finally, the suppressive role of the tumor microenvironment in vaccination efficacy and some proposals to overcome this by using combination therapies will be described.
Modeling Population Dynamics in Changing Environments

Discrete replicator dynamics view evolution as a coordination game played among genes. While previous models of discrete replicator dynamics do not consider environments that respond to the mixed strategy that a population plays, our model incorporates a feedbackbased payoff matrix, which depends on the frequency distribution of alleles. In this model, we construct an environment that is composed of multiple environments with different Nash equilbria. We look at whether the population dynamics converge or whether they exhibit a different behavior, e.g. whether they oscillate and form a stable limit cycle. We provide evidence that with only two Nash equilibria, i.e. two environments, the system will always converge to a fixed point along the line a + b = 1. With three Nash equilibria, although we were unable to construct a cyclic behavior, we conjecture that it is possible. Finally, with four Nash equilbria, we give evidence that it is possible for the system to form a stable limit cycle.
Sound and Complete Landmarks for And/Or Graphs

Landmarks for a planning problem are subgoals that are necessarily made true at some point in the execution of any plan. Since verifying that a fact is a landmark is PSPACE-complete, earlier approaches have focused on finding landmarks for the delete relaxation Π+. Furthermore, some of these approaches have approximated this set of landmarks, although it has been shown that the complete set of causal delete-relaxation landmarks can be identified in polynomial time by a simple procedure over the relaxed planning graph. Here, we give a declarative characterisation of this set of landmarks and show that the procedure computes the landmarks described by our characterisation. Building on this, we observe that the procedure can be applied to any delete-relaxation problem and take advantage of a recent compilation of the m-relaxation of a problem into a problem with no delete effects to extract landmarks that take into account delete effects in the original problem. We demonstrate that this approach finds strictly more causal landmarks than previous approaches and discuss the relationship between increased computational effort and experimental performance, using these landmarks in a recently proposed admissible landmark-counting heuristic.
TRAFFIC SIGN DETECTION BASED ON BIOLOGICALLY VISUAL MECHANISM

TSR (Traffic sign recognition) is an important problem in ITS (intelligent traffic system), which is being paid more and more attention for realizing drivers assisting system and unmanned vehicle etc. TSR consists of two steps: detection and recognition, and this paper describe a new traffic sign detection method. The design principle of the traffic sign is comply with the visual attention mechanism of human, so we propose a method using visual attention mechanism to detect traffic sign ,which is reasonable. In our method, the whole scene will firstly be analyzed by visual attention model to acquire the area where traffic signs might be placed. And then, these candidate areas will be analyzed according to the shape characteristics of the traffic sign to detect traffic signs. In traffic sign detection experiments, the result shows the proposed method is effectively and robust than other existing saliency detection method.
Association Cluster Detector: a tool for heuristic detection of significance clusters in whole-genome scans

UNLABELLED Whole genome scans analyze large sets of genetic markers, mainly single nucleotide polymorphisms, over the entire genome in order to find variants and regions associated with complex traits so these can be further investigated. Analyzing the results of such scans becomes difficult due to multiple testing problems and to the genomic distributions of recombination, linkage disequilibrium and true associations, which generate an extremely complex network of dependences between markers. Here we present Association Cluster Detector (ACD), a simple tool aiming to ease the analysis of the results of whole genome scans. ACD facilitates correction for multiple tests using several standard procedures and implements a sliding-window heuristic method that helps in detecting potentially interesting candidate regions by exploiting the property of non-random distribution of significantly associated markers. AVAILABILITY The tool can be downloaded from http://www.upf. es/cexs/recerca/bioevo/softanddata.htm
Elastic scattering from cubic lattice systems with paracrystalline distortion. II.

The three-dimensional paracrystalline lattice factors Z(q)'s for a face-centered-cubic lattice and a body-centered-cubic lattice, in addition to a simple-cubic lattice, were calculated. The Z(q)'s thus calculated could reproduce the diffraction peaks at the characteristic positions for each cubic lattice system over a fairly wide range of g values (g is the degree of the paracrystalline distortion). In addition to the paracrystalline distortion, the thermal oscillation and crystal size effects were also considered. The numerically calculated profiles were compared with light and small-angle neutron scattering curves for polymer latex dispersions and with small-angle x-ray scattering curves for block copolymer films for quantitative determination of the ordered cubic systems.
Light Induced and Circadian Effects on Retinal Photoreceptor Cell Crystallins

Crystallins in the retina may serve a chaperone‐like protective function. In this study we measured mRNA levels for alpha‐, beta‐ and gamma‐crystallins in rat retinas following treatment with potentially damaging levels of light. We also determined crystallin protein patterns in photoreceptor cell rod outer segments (ROSs) isolated from rats exposed to intense light. Weanling albino rats were maintained in a dim cyclic light environment or in darkness for 40 days. At P60 animals were treated with intense visible light, for as long as 8 h, beginning at various times of the day or night. Retinas were excised immediately after light treatment and used for quantitative RT‐PCR, or to prepare ROSs for western analysis. Some eyes were frozen in OCT for crystallin immunohistochemistry. Intense light exposure led to increases in mRNA expression for all retinal crystallins and to changes in ROS crystallin immunoreactivity. These light‐induced changes were found to depend on the time of day that exposure started, duration of light treatment and previous light rearing history. We suggest that crystallin synthesis in retina exhibits a dependence on both light stress and circadian rhythm and that within photoreceptor cells crystallins appear to migrate in a light‐independent, circadian fashion.
A Hybrid Genetic Wind Driven Heuristic Optimization Algorithm for Demand Side Management in Smart Grid

In recent years, demand side management (DSM) techniques have been designed for residential, industrial and commercial sectors. These techniques are very effective in flattening the load profile of customers in grid area networks. In this paper, a heuristic algorithms-based energy management controller is designed for a residential area in a smart grid. In essence, five heuristic algorithms (the genetic algorithm (GA), the binary particle swarm optimization (BPSO) algorithm, the bacterial foraging optimization algorithm (BFOA), the wind-driven optimization (WDO) algorithm and our proposed hybrid genetic wind-driven (GWD) algorithm) are evaluated. These algorithms are used for scheduling residential loads between peak hours (PHs) and off-peak hours (OPHs) in a real-time pricing (RTP) environment while maximizing user comfort (UC) and minimizing both electricity cost and the peak to average ratio (PAR). Moreover, these algorithms are tested in two scenarios: (i) scheduling the load of a single home and (ii) scheduling the load of multiple homes. Simulation results show that our proposed hybrid GWD algorithm performs better than the other heuristic algorithms in terms of the selected performance metrics.
Different Domains of CD81 Mediate Distinct Stages of Hepatitis C Virus Pseudoparticle Entry

ABSTRACT The CD81 tetraspanin was first identified as a hepatitis C virus (HCV) receptor by its ability to bind the soluble ectodomain of envelope glycoprotein E2 (sE2). More recently, it has been suggested that CD81 is necessary but not sufficient for HCV entry into target cells. Here we present further evidence that putative human hepatocyte-specific factors act in concert with CD81 to mediate sE2 binding and HCV pseudoparticle (HCVpp) entry. Moreover, we show that CD81-mediated HCVpp entry entails E2 binding to residues in the large extracellular loop as well as molecular events mediated by the transmembrane and intracellular domains of CD81. The concept that CD81 receptor function progresses in stages is further supported by our finding that anti-CD81 monoclonal antibodies inhibit HCVpp entry by different mechanisms. The half-life of CD81-HCVpp binding was determined to be approximately 17 min, and we propose that binding is followed by CD81 oligomerization, partitioning into cholesterol-rich membrane domains, or other, lateral protein-protein interactions. This results in the formation of a receptor-virus complex that undergoes endocytosis and pH-dependent membrane fusion.
Robust Closed-Loop Control of the Inspired Fraction of Oxygen for the Online Assessment of Recruitment Maneuvers

Recruitment maneuvers are commonly used in patients suffering from acute respiratory failure. A continuous measurement of PaO2 would help to assess the proper execution of such maneuvers. Unfortunately, there are only static offline measurement devices available. However, if the oxygen saturation would be held close to a fixed set-point of 90-92% by automatically adjusting the FIO2 parameter of the mechanical ventilator, the latter would be inversely related to PaO2. In this work, a new robust PID control system is presented, which accounts for model uncertainty in a modified Smith predictor approach. The controller was tested using a computer model of respiratory failure. The model parameters were identified in an animal experiment with pigs.
Flow Injection Analysis with Electrochemical Detection for Rapid Identification of Platinum-Based Cytostatics and Platinum Chlorides in Water

Platinum-based cytostatics, such as cisplatin, carboplatin or oxaliplatin are widely used agents in the treatment of various types of tumors. Large amounts of these drugs are excreted through the urine of patients into wastewaters in unmetabolised forms. This phenomenon leads to increased amounts of platinum ions in the water environment. The impacts of these pollutants on the water ecosystem are not sufficiently investigated as well as their content in water sources. In order to facilitate the detection of various types of platinum, we have developed a new, rapid, screening flow injection analysis method with electrochemical detection (FIA-ED). Our method, based on monitoring of the changes in electrochemical behavior of analytes, maintained by various pH buffers (Britton-Robinson and phosphate buffer) and potential changes (1,000, 1,100 and 1,200 mV) offers rapid and cheap selective determination of platinum-based cytostatics and platinum chlorides, which can also be present as contaminants in water environments.
Detection of spontaneous class-specific visual stimuli with high temporal accuracy in human electrocorticography

Most brain-computer interface classification experiments from electrical potential recordings have been focused on the identification of classes of stimuli or behavior where the timing of experimental parameters is known or pre-designated. Real world experience, however, is spontaneous, and to this end we describe an experiment predicting the occurrence, timing, and types of visual stimuli perceived by a human subject from electrocorticographic recordings. All 300 of 300 presented stimuli were correctly detected, with a temporal precision of order 20ms. The type of stimulus (face/house) was correctly identified in 95% of these cases. There were ~20 false alarm events, corresponding to a late 2nd neuronal response to a previously identified event.
Apertureless scanning near-field optical microscopy: a comparison between homodyne and heterodyne approaches

In coherent homodyne apertureless scanning near-field optical microscopy (ASNOM) the background field cannot be fully suppressed because of the interference between the different collected fields, making the images difficult to interpret. We show that implementing the heterodyne version of ASNOM allows one to overcome this issue. We present a comparison between homodyne and heterodyne ASNOM through near-field analysis of gold nanowells, integrated waveguides, and a single evanescent wave generated by total internal reflection. The heterodyne approach allows for the control of the interferometric effect with the background light. In particular, the undesirable background is shown to be replaced by a controlled reference field. As a result, near-field information undetectable by a homodyne ASNOM is extracted by use of the heterodyne approach. Additionally, it is shown that field amplitude and field phase can be detected separately.
Aging Enhances Autonomic Support of Blood Pressure in Women

The autonomic nervous system plays a central role in both acute and chronic blood pressure regulation in humans. The activity of the sympathetic branch of the autonomic nervous system is positively associated with peripheral resistance, an important determinant of mean arterial pressure in men. In contrast, there is no association between sympathetic nerve activity and peripheral resistance in women before menopause, yet a positive association after menopause. We hypothesized that autonomic support of blood pressure is higher after menopause in women. We examined the effect of ganglionic blockade on arterial blood pressure and how this relates to baseline muscle sympathetic nerve activity in 12 young (25±1 years) and 12 older postmenopausal (61±2 years) women. The women were studied before and during autonomic blockade using trimethaphan camsylate. At baseline, muscle sympathetic nerve activity burst frequency and burst incidence were higher in the older women (33±3 versus 15±1 bursts/min; 57±5 versus 25±2 bursts/100 heartbeats, respectively; P<0.05). Muscle sympathetic nerve activity bursts were abolished by trimethaphan within minutes. Older women had a greater decrease in mean arterial pressure (−29±2 versus −9±2 mm Hg; P<0.01) and total peripheral resistance (−10±1 versus −5±1 mm Hg/L per minute; P<0.01) during trimethaphan. Baseline muscle sympathetic nerve activity was associated with the decrease in mean arterial pressure during trimethaphan (r=−0.74; P<0.05). In summary, our results suggest that autonomic support of blood pressure is greater in older women compared with young women and that elevated sympathetic nerve activity in older women contributes importantly to the increased incidence of hypertension after menopause.
Personalized and automatic social summarization of events in video

Social services like Twitter are increasingly used to provide a conversational backdrop to real-world events in real-time. Sporting events are a good example of this and this year, millions of users tweeted their comments as they watched the World Cup matches from around the world. In this paper, we look at using these time-stamped opinions as the basis for generating video highlights for these soccer matches. We introduce the PASSEV system and describe and evaluate two basic summarization approaches.
Predicting Technique of Delamination at Adhesively Bonding Joints in a Flip Chip Package During Solder Reflow Process

Recently, adhesively bonding techniques such as the anisotropic conductive film (ACF) or the non-conductive adhesive resin are often used for connections in the chip size packages instead of conventional solder joints due to their reasonable cost and the ease of miniaturization. Adhesively bonding techniques expected to be a key technology for the chip size packaging and the system in package. However, the level of reliability for adhesively bonding techniques is still less than that for solder joints. The quantitative evaluation techniques for the reliability of adhesively bonding techniques are desired. This paper focused on the reliability of adhesively bonding joints in a flip chip package during the solder reflow process for other solder jointed devices. This paper presents a methodology for quantitative evaluation of the delamination in a flip chip interconnected by an ACF under moisture/reflow sensitivity tests. The delamination toughnesses between components in a flip chip based on the stress intensity factors were measured by fracture tests in conjunction with the numerical analysis developed in our previous study. Moisture concentration after moisture absorption was expected by the diffusion analysis using the finite element method. Then, vapor pressure in a flip chip during the solder reflow process was estimated. Finally the delamination was predicted by comparing the stress intensity factor of an interface crack due to vapor pressure with the delamination toughness. The delaminations in an actual flip chip package during moisture/reflow sensitivity tests have successfully predicted by the present methodology.Copyright © 2005 by ASME
Non-rigid registration based segmentation of brain subcortical structures using a priori knowledge

Segmentation of the brain internal structures is an important and a challenging task due to their complex shapes, partial volume effects, low contrasts and anatomical variability between subjects. In this paper we propose a new non-rigid registration method that automatically segments the deep brain internal structures from brain MRI images. An atlas of the structures is used as a priori knowledge, which is modeled as a shape representation. By integrating the shape knowledge into a classical intensity based non-rigid registration algorithm, the proposed segmentation method allows to ameliorate the results in the case of low contrast on the boundaries of the structures. The shape model is based on distance representation obtained from the atlas. The segmentation of brain subcortical structures is performed on real MRI images and the obtained results are very encouraging.