Miracle-dz/UniFAR-FTUs huggingface dataset:
Phemindole, a Synthetic Di-indole Derivative Maneuvers the Store Operated Calcium Entry (SOCE) to Induce Potent Anti-Carcinogenic Activity in Human Triple Negative Breast Cancer Cells

Triple-negative breast cancer (TNBC), is a specific subtype of epithelial breast tumors that are immuno-histochemically negative for the protein expression of the estrogen receptor (ER), the progesterone receptor (PR) and lack over expression/gene amplification of HER2. This subtype of breast cancers is highly metastatic, shows poor prognosis and hence represents an important clinical challenge to researchers worldwide. Thus alternative approaches of drug development for TNBC have gained utmost importance in the present times. Dietary indole and its derivatives have gained prominence as anti-cancer agents and new therapeutic approaches are being developed to target them against TNBC. But a major drawback with 3, 3′di Indolyl methane (DIM) is their poor bioavailability and high effective concentration against TNBC. However, the Aryl methyl ring substituted analogs of DIM display interesting anti-cancer activity in breast cancer cells. In the current study we report the synthesis of a novel synthetic aryl methyl ring substituted analog of DIM, named as Phemindole as an effective anti-tumor agent against TNBC cells. Furthermore, we enumerated that Phemindole caused reactive oxygen species mediated mitochondrial-dependent apoptosis in MDAMB-231 cells. Furthermore, Phemindole mediated Store Operated Calcium Entry (SOCE) retardation favored inactivation of STIM1 and henceforth activated ER stress to induce apoptosis in TNBC cells. Simultaneously, Phemindole was also found to restrict the in vitro cell migration through its anti mitotic property and pFAK regulation. Studies extended to ex ovo and in vivo mice models further validated the efficacy of Phemindole. Thus our results cumulatively propose Phemindole as a new chemotherapeutic regime which might be effective to target the deadly aspects of the TNBC.
FRP-RC Beam in Shear: Mechanical Model and Assessment Procedure for Pseudo-Ductile Behavior

This work deals with the development of a mechanics-based shear model for reinforced concrete (RC) elements strengthened in shear with fiber-reinforced polymer (FRP) and a design/assessment procedure capable of predicting the failure sequence of resisting elements: the yielding of existing transverse steel ties and the debonding of FRP sheets/strips, while checking the corresponding compressive stress in concrete. The research aims at the definition of an accurate capacity equation, consistent with the requirement of the pseudo-ductile shear behavior of structural elements, that is, transverse steel ties yield before FRP debonding and concrete crushing. For the purpose of validating the proposed model, an extended parametric study and a comparison against experimental results have been conducted: it is proven that the common accepted rule of assuming the shear capacity of RC members strengthened in shear with FRP as the sum of the maximum contribution of both FRP and stirrups can lead to an unsafe overestimation of the shear capacity. This issue has been pointed out by some authors, when comparing experimental shear capacity values with the theoretical ones, but without giving a convincing explanation of that. In this sense, the proposed model represents also a valid instrument to better understand the mechanical behavior of FRP-RC beams in shear and to calculate their actual shear capacity.
Ray-based approach to integrated 3D visual communication

For a high sense of reality in the next-generation communications, it is very important to realize three-dimensional (3D) spatial media, instead of existing 2D image media. In order to comprehensively deal with a variety of 3D visual data formats, the authors first introduce the concept of ”Integrated 3D Visual Communication,” which reflects the necessity of developing a neutral representation method independent of input/output systems. Then, the following discussions are concentrated on the ray-based approach to this concept, in which any visual sensation is considered to be derived from a set of light rays. This approach is a simple and straightforward to the problem of how to represent 3D space, which is an issue shared by various fields including 3D image communications, computer graphics, and virtual reality. This paper mainly presents the several developments in this approach, including some efficient methods of representing ray data, a real-time video-based rendering system, an interactive rendering system based on the integral photography, a concept of virtual object surface for the compression of tremendous amount of data, and a light ray capturing system using a telecentric lens. Experimental results demonstrate the effectiveness of the proposed techniques.
Peningkatan Hasil Belajar Sosiologi Pokok Bahasan Interaksi Sosial Melalui Metode Diskusi pada Siswa Kelas X MA. Muhammadiyah Panaikang Kacamatan Bissappu Kabupten Bantaeng

The objective of this research is to improve the sociology learning outcomes of social interaction subjects with the method of discussion on the students of class X MA. Muhammadiyah Panaikang Kacamatan Bissappu Kabanta Bantaeng. This study included descriptive research designed through classroom action research, conducted in two cycles, each cycle was held as many as 4 times meeting with the number of students 34 people (13 men and 21 women). The instrument of this research is test and observation sheet. The data of the research are analyzed quantitatively and qualitatively. The results of this study showed: (1) Student learning achievement cycle I average 53.70 and increase in cycle II with an average of 82. Learning completeness in the first cycle of 58.82% and increased in cycle II to 57, 05% . Thus, the learning method can improve student's sociology learning outcomes. (2) Discussion method can increase students' activity in learning. Indicators of improvement can be observed based on observations from cycle I and to cycle II that undergo changes, the emergence of changes, motivation, enthusiasm, and the value of student learning students understand the material. Keywords: Learning Outcomes, Discussion Methods, Student Activity.
The dual effects of task conflict on team creativity

PurposeThe purpose of this paper is to explore the dual effects of task conflict on team creativity and the role of team-focused transformational leadership (TFL) as a key contingency in the task conflict–team creativity relationship.Design/methodology/approachData were collected from 325 teams across ten large companies in South Korea. The study tested the hypothesized moderated mediation model using an SPSS macro (PROCESS, Hayes, 2008). FindingsResults showed that task conflict is directly and positively related to team creativity and is negatively and indirectly related to team creativity via relationship conflict. Furthermore, the study found that team-focused TFL moderates all paths through which task conflict affects team creativity. Specifically, team-focused TFL enhances the positive direct effect of task conflict and alleviates the negative indirect effects of task conflict on team creativity.Research limitations/implicationsAlthough this study could not test the causal chains of the proposed relationships owing to a cross-sectional nature of data, the present research provides theoretical implications for the conflict, leadership and team creativity literatures. The study highlights the role of transformational leadership in the process through which team conflict is managed so as to increase team creativity.Practical implicationsTo capitalize on the creativity-related benefits associated with task conflict, managers will need to pay attention to the role they can play and their leadership that emphasizes collective goals and identity. Managers and team leaders are also expected to intervene in conflict situations to minimize the harmful effect of task conflict that may take place owing to the association between task conflict and relationship conflict.Social implicationsThe findings will have implications for any social contexts where people work together toward common goals. In such contexts, the study emphasizes the role of leadership in teams to use the creative potential associated with different opinions and values regarding what and how work to be completed.Originality/valueThe study’s examination of the dual paths through which task conflict affects team creativity brings insights into why the impact of task conflict on team creativity has been inconsistent or unclear in past research. This paper also articulates a leader’s role in teams in relation to managing team conflict to increase team creativity.
Design Pattern Decay: An Extended Taxonomy and Empirical Study of Grime and its Impact on Design Pattern Evolution

Design patterns are well known solutions to common problems and are extensively utilized in software development. Yet, little empirical work has been conducted to evaluate or validate the consequences that poor design decisions have on pattern realizations. This paper describes a research program to further the understanding of design pattern evolution. Specifically, we focus on design pattern decay by studying how grime, a decisively negative consequence of software evolution occurs. The research proposed herein furthers the exploration of design pattern decay by providing empirical evidence of grime buildup, a new grime taxonomy, and the consequences exhibited through decreased adaptability and maintainability in actual realizations of patterns in code. These notions will be supported through the development of semi-automated grime detection and refactoring research tools that will also link to existing forms of design decay such as code smells, anti-patterns, and modularity violations. An extension of this research focuses on the exploration of these notions inlying coupled pattern realizations.
Focal Exocytosis of Vamp3-Containing Vesicles at Sites of Phagosome Formation

Phagocytosis involves the receptor-mediated extension of plasmalemmal protrusions, called pseudopods, which fuse at their tip to engulf a particle. Actin polymerizes under the nascent phagosome and may propel the protrusion of pseudopods. Alternatively, membrane extension could result from the localized insertion of intracellular membranes into the plasmalemma next to the particle. Here we show focal accumulation of VAMP3-containing vesicles, likely derived from recycling endosomes, in the vicinity of the nascent phagosome. Using green fluorescent protein (GFP) as both a fluorescent indicator and an exofacial epitope tag, we show that polarized fusion of VAMP3 vesicles precedes phagosome sealing. It is therefore likely that targeted delivery of endomembranes contributes to the elongation of pseudopods. In addition to mediating pseudopod formation, receptor-triggered focal secretion of endosomes may contribute to polarized membrane extension in processes such as lamellipodial elongation or chemotaxis.
Effects of Quran Recitation on Heart Rate Variability as an indicator of Student Emotions

This study examined the effects of Quran recitation on the Heart Rate Variability (HRV) of students. By doing so, this research extends previous findings on the effects of religious activities on university students. This research therefore studies the relationship between HRV with different Quran recitation types with different reading styles (Tajweed), Surah (stories) and themes (i.e. heaven, hell and punishment). The experiment comprises four sessions that each lasted approximately 30 minutes and that involved the recitation of certain Quran Surah or verses. At the end of each session, the difference between pre- and postsession HRVs was derived. The results of this research may be used to help university students reduce stress, tension and anxiety.
Goal-driven learning

Learning, goals, and learning goals, Ashwin Ram and David B. Leake. Part 1 Current state of the field: planning to learn, Lawrence Hunter quantitative results concerning the utility of explanation-based learning, Steven Minton the use of explicit goals for knowledge to guide inference and learning, Ashwin Ram and Lawrence Hunter deriving categories to achieve goals, Lawrence W. Barsalou harpoons and long sticks - the interaction of theory and similarity in rule induction, Edward J. Wisniewski and Douglas L. Medlin introspective reasoning using meta-explanations for multistrategy learning, Ashwin Ram and Michael T. Cox goal-directed learning - a decision-theoretic model for deciding what to learn next, Marie desJardins goal-based explanation evaluation, David B. Leake planning to perceive, Louise Pryor and Gregg Collins planning and learning in PRODIGY - overview of an integrated architecture, Jaime Carbonell et al a learning model for the selection of problem-solving strategies in continuous physical systems, Xiaodong Xia and Dit-Yan Yeung explicitly biased generalization, Diana Gordon and Donald Perlis three levels of goal orientation in learning, Evelyn Ng and Carl Bereiter characterizing the application of computer simulations in education - instructional criteria, Jos J.A. van Berkum et al. Part 2 Current research and recent directions: goal-driven learning - fundamental issues and symposium report, David B. Leake and Ashwin Ram storage side effects - studying processing to understand learning, Lawrence W. Barsalou goal-driven learning in multistrategy reasoning and learning systems, Ashwin Ram et al inference to the best plan - a coherence theory of decision, Paul Thagard and Elijah Millgram toward goal-driven integration of explanation and action, David B. Leake learning as goal-driven inference, Ryszard Michalski and Ashwin Ram.
Associations Between Fathers’ Work-to-Family Spillover and Their Ways to Track Children’s Whereabouts and Doings: A Hong Kong Study

Utilizing a Hong Kong Chinese sample, this study examined how fathers’ negative work-to-family spillover was associated with their behaviors in monitoring their children’s daily doings. In total, 125 fathers with a focal child at fifth or sixth grade were invited to complete a survey. Results revealed that work spillover was negatively associated with child self-disclosure, father solicitation, and father listening and observing children, and the associations for child self-disclosure and father solicitation were mediated by father–child relations. A marginally significant positive association between work spillover and getting information from spouse was also found. The results suggest that work stress poses difficulty to fathers in directly monitoring their children and pushes them to rely on mothers as the source of knowledge.
Gene Expression Analysis Implicates a Death Receptor Pathway in Schizophrenia Pathology

An increase in apoptotic events may underlie neuropathology in schizophrenia. By data-mining approaches, we identified significant expression changes in death receptor signaling pathways in the dorsolateral prefrontal cortex (DLPFC) of patients with schizophrenia, particularly implicating the Tumor Necrosis Factor Superfamily member 6 (FAS) receptor and the Tumor Necrosis Factor [ligand] Superfamily member 13 (TNFSF13) in schizophrenia. We sought to confirm and replicate in an independent tissue collection the noted mRNA changes with quantitative real-time RT-PCR. To test for regional and diagnostic specificity, tissue from orbital frontal cortex (OFC) was examined and a bipolar disorder group included. In schizophrenia, we confirmed and replicated significantly increased expression of TNFSF13 mRNA in the DLPFC. Also, a significantly larger proportion of subjects in the schizophrenia group had elevated FAS receptor expression in the DLPFC relative to unaffected controls. These changes were not observed in the bipolar disorder group. In the OFC, there were no significant differences in TNFSF13 or FAS receptor mRNA expression. Decreases in BH3 interacting domain death agonist (BID) mRNA transcript levels were found in the schizophrenia and bipolar disorder groups affecting both the DLPFC and the OFC. We tested if TNFSF13 mRNA expression correlated with neuronal mRNAs in the DLPFC, and found significant negative correlations with interneuron markers, parvalbumin and somatostatin, and a positive correlation with PPP1R9B (spinophilin), but not DLG4 (PSD-95). The expression of TNFSF13 mRNA in DLPFC correlated negatively with tissue pH, but decreasing pH in cultured cells did not cause increased TNFSF13 mRNA nor did exogenous TNFSF13 decrease pH. We concluded that increased TNFSF13 expression may be one of several cell-death cytokine abnormalities that contribute to the observed brain pathology in schizophrenia, and while increased TNFSF13 may be associated with lower brain pH, the change is not necessarily causally related to brain pH.
Isolation and identification of feline calicivirus and feline herpesvirus in Southern Brazil

Feline calicivirus (FCV) and feline herpesvirus type 1 (FHV-1) are the two primary causes of upper respiratory tract disease in cats. The aim of this study was to demonstrate the distribution of FCV and FHV-1 among the feline population of several counties in Rio Grande do Sul State, Brazil. To this end, conjunctival and nasal swabs were collected from 302 cats from different locations, including households, breeding catteries, veterinary clinics, animal hospitals and experimental research facilities. The samples were collected between July 2006 to June 2009. The virus isolation was performed in CRFK cells and, subsequently, the identification was confirmed by PCR. FCV, FHV-1, or both were isolated from 55 cats from 28 different locations. FCV alone was isolated from 52.7% (29/55) of the animals that tested positively, FHV-1 alone was isolated from 38.2% (21/55) of the animals that tested positively, and co-infection were detected in 9.1% (5/55) of the animals that tested positively. Virus detection was more prevalent in cats that were less than 1 year old, among animals that shared a living space with other cats, and females. FCV and FHV-1 were isolated from vaccinated cats. In addition, both viruses were isolated from cats that showed no signs of disease. The results suggest that a carrier state is common for both viruses in the evaluated population. A search for other causes of respiratory disease in that population is necessary; and further studies relating to the molecular characterization of viruses and vaccine efficacy are also necessary.
Turkish Broadcast News Transcription and Retrieval

This paper summarizes our recent efforts for building a Turkish Broadcast News transcription and retrieval system. The agglutinative nature of Turkish leads to a high number of out-of-vocabulary (OOV) words which in turn lower automatic speech recognition (ASR) accuracy. This situation compromises the performance of speech retrieval systems based on ASR output. Therefore using a word-based ASR is not adequate for transcribing speech in Turkish. To alleviate this problem, various sub-word-based recognition units are utilized. These units solve the OOV problem with moderate size vocabularies and perform even better than a 500 K word vocabulary as far as recognition accuracy is concerned. As a novel approach, the interaction between recognition units, words and sub-words, and discriminative training is explored. Sub-word models benefit from discriminative training more than word models do, especially in the discriminative language modeling framework. For speech retrieval, a spoken term detection system based on automata indexation is utilized. As with transcription, retrieval performance is measured under various schemes incorporating words and sub-words. Best results are obtained using a cascade of word and sub-word indexes together with term-specific thresholding.
The Influence of Urinary Concentrations of Organophosphate Metabolites on the Relationship between BMI and Cardiometabolic Health Risk

The objective was to determine whether detectable levels of OP metabolites influence the relationship between BMI and cardiometabolic health. This cross-sectional study was conducted using 2227 adults from the 1999–2008 NHANES datasets. Urinary concentrations of six dialkyl phosphate metabolites were dichotomized to above and below the detection limit. Weighted multiple regression analysis was performed adjusting for confounding variables. Independent of BMI, individuals with detectable metabolites had higher diastolic blood pressure (for dimethylphosphate, diethylphosphate, and diethyldithiophosphate; P < 0.05), lower HDL (for diethyldithiophosphate; P = 0.02), and higher triglyceride (for dimethyldithiophosphate; P = 0.05) than those below detection. Contrarily, those with detectable dimethylthiophosphate had better LDL, HDL, and total cholesterol, independent of BMI. Individuals at a higher BMI range who had detectable diethylphosphate (interaction: P = 0.03) and diethylthiophosphate (interaction: P = 0.02) exhibited lower HDL, while little difference existed between OP metabolite detection statuses at lower BMIs. Similarly, individuals with high BMIs and detectable diethylphosphate had higher triglyceride than those without detectable levels, while minimal differences between diethylphosphate detection statuses were observed at lower BMIs (interaction: P = 0.02). Thus, cardiometabolic health outcome differs depending on the specific OP metabolite being examined, with higher BMIs amplifying health risk.
Child protection and cultural awareness: Simulation-based learning

ABSTRACT Social work educators have long struggled with the challenge of finding appropriate strategies for fostering cultural awareness among their students. The purpose of this study is to illustrate how a computer-based simulation, SimChild, can be used in teaching about child protection to enhance cultural awareness among students and expand their insight into how personal biases can affect professional practice. In SimChild, individual students can assume the role of social worker and then collectively discuss the patterns emerging after their individual assessments have been aggregated. This study, based primarily on focus group data, reflects testing conducted at three Swedish universities.
Predicting the Activity Coefficients of Free-Solvent for Concentrated Globular Protein Solutions Using Independently Determined Physical Parameters

The activity coefficient is largely considered an empirical parameter that was traditionally introduced to correct the non-ideality observed in thermodynamic systems such as osmotic pressure. Here, the activity coefficient of free-solvent is related to physically realistic parameters and a mathematical expression is developed to directly predict the activity coefficients of free-solvent, for aqueous protein solutions up to near-saturation concentrations. The model is based on the free-solvent model, which has previously been shown to provide excellent prediction of the osmotic pressure of concentrated and crowded globular proteins in aqueous solutions up to near-saturation concentrations. Thus, this model uses only the independently determined, physically realizable quantities: mole fraction, solvent accessible surface area, and ion binding, in its prediction. Predictions are presented for the activity coefficients of free-solvent for near-saturated protein solutions containing either bovine serum albumin or hemoglobin. As a verification step, the predictability of the model for the activity coefficient of sucrose solutions was evaluated. The predicted activity coefficients of free-solvent are compared to the calculated activity coefficients of free-solvent based on osmotic pressure data. It is observed that the predicted activity coefficients are increasingly dependent on the solute-solvent parameters as the protein concentration increases to near-saturation concentrations.