Miracle-dz/UniFAR-FTUs huggingface dataset:
From Into Out-patient Artificial Pancreas Studies : Results And New Developments

The Artificial Pancreas (AP) is a device for closed-loop modulation of insulin infusion, aiming to maintain patient glycemia in a nearly normal range. In the last decade AP prototypes using subcutaneous glucose sensing and subcutaneous insulin delivery have been extensively studied in clinical trials involving hospitalized patients. To ensure the highest level of patient safety, these studies usually employed very structured protocols and subcutaneous glucose measurements were accompanied by frequent and accurate blood glucose measurements via intravenous sampling. Therefore, in-patient studies were usually short and patients were often unable to move freely. The next step in the AP development is testing safety and efficacy of AP in a real-life scenario, outside the hospital environment and free of strict protocol prescriptions. This paper offers a review of some technological and algorithmic challenges posed by the in-to out-patient transition and reports the authors’ experience in making this transition possible. Issues related to devices, telemedicine and control algorithms are discussed and outpatient clinical results are presented in support.
Bi-class classification of humpback whale sound units against complex background noise with Deep Convolution Neural Network

Automatically detecting sound units of humpback whales in complex time-varying background noises is a current challenge for scientists. In this paper, we explore the applicability of Convolution Neural Network (CNN) method for this task. In the evaluation stage, we present 6 bi-class classification experimentations of whale sound detection against different background noise types (e.g., rain, wind). In comparison to classical FFT-based representation like spectrograms, we showed that the use of image-based pretrained CNN features brought higher performance to classify whale sounds and background noise.
Effects of Different Extraction Methods and Conditions on the Phenolic Composition of Mate Tea Extracts

A simple and rapid HPLC method for determination of chlorogenic acid (5-O-caffeoylquinic acid) in mate tea extracts was developed and validated. The chromatography used isocratic elution with a mobile phase of aqueous 1.5% acetic acid-methanol (85:15, v/v). The flow rate was 0.8 mL/min and detection by UV at 325 nm. The method showed good selectivity, accuracy, repeatability and robustness, with detection limit of 0.26 mg/L and recovery of 97.76%. The developed method was applied for the determination of chlorogenic acid in mate tea extracts obtained by ethanol extraction and liquid carbon dioxide extraction with ethanol as co-solvent. Different ethanol concentrations were used (40, 50 and 60%, v/v) and liquid CO2 extraction was performed at different pressures (50 and 100 bar) and constant temperature (27 ± 1 °C). Significant influence of extraction methods, conditions and solvent polarity on chlorogenic acid content, antioxidant activity and total phenolic and flavonoid content of mate tea extracts was established. The most efficient extraction solvent was liquid CO2 with aqueous ethanol (40%) as co-solvent using an extraction pressure of 100 bar.
The Metabolism of Polysaccharide from Atractylodes macrocephala Koidz and Its Effect on Intestinal Microflora

An active polysaccharide from the rhizome of Atractylodes macrocephala Koidz (PAM) was identified to improve and adjust disordered intestinal flora. High-performance gel permeation chromatography (HPGPC) and gas chromatography-mass spectrometry (GC-MS) were employed to identify the components of PAM as rhamnose, glucose, mannose, xylose, and galactose at a ratio of 0.03 : 0.25 : 0.15 : 0.41 : 0.15. PAM metabolized in gastrointestinal tract when incubated with artificial gastric and intestinal juices. Anaerobic incubation of PAM on intestinal flora confirmed that PAM promoted the ability of intestinal bacteria to digest reducing sugar. Based on the Shannon index and similarity coefficient index of enterobacterial repetitive intergenic consensus-PCR (ERIC-PCR) fingerprinting of the total intestinal bacteria DNA, we concluded that PAM can significantly improve disordered intestinal flora and may be used as an oral adjuvant to regulate intestinal flora.
Mimetic Communication Model with Compliant Physical Contact in Human—Humanoid Interaction

In this paper we aim at extending imitation learning to physical human—robot interaction (pHRI) including contact transitions (from non-contact to contact and vice versa). For interactive learning of pHRI, the paper raises four key issues: (1) motion imitation, (2) understanding motion primitives, (3) understanding interaction primitives, and (4) physical contact establishment. These issues are solved by (1) marker control, (2) mimesis model, (3) mimetic communication model, and (4) real-time motion reshaping and impedance control, respectively. The simple human motion imitation is realized by a direct marker control method in which the robot is virtually connected to the markers attached to the human via virtual springs. Learning procedures are based on ‘‘imitation of a human’’ and ‘‘active involvement’’ of the robot during the learning. The ‘‘imitation of a human’’ scheme provides efficient learning. The ‘‘active involvement’’ scheme supports incremental learning and it also enables to acquire sensory information for physical contacts. By modifying the mimetic communication model proposed by Nakamura et al., we achieve communication in physical domain as well as the symbolic domain. The communication in the symbolic domain is realized through the concept of motion primitives and interaction primitives. In the physical domain, the trajectory of the motion primitive is reshaped in accordance with the human’s motions in real-time. Moreover, for performing compliant contact motion, an appropriate impedance controller is integrated into the setting. All of the presented concepts are applied to ‘‘high five’’-like interaction tasks and evaluated in experiments with a human-size humanoid robot.
Rvs161p Interacts with Fus2p to Promote Cell Fusion in Saccharomyces cerevisiae

FUS7 was previously identified by a mutation that causes a defect in cell fusion in a screen for bilateral mating defects. Here we show that FUS7 is allelic to RVS161/END6, a gene implicated in a variety of processes including viability after starvation, endocytosis, and actin cytoskeletal organization. Two lines of evidence indicate that RVS161/END6's endocytic function is not required for cell fusion. First, several other endocytic mutants showed no cell fusion defects. Second, we isolated five function-specific alleles of RVS161/FUS7 that were defective for endocytosis, but not mating, and three alleles that were defective for cell fusion but not endocytosis. The organization of the actin cytoskeleton was normal in the cell fusion mutants, indicating that Rvs161p's function in cell fusion is independent of actin organization. The three to fourfold induction of RVS161 by mating pheromone and the localization of Rvs161p-GFP to the cell fusion zone suggested that Rvs161p plays a direct role in cell fusion. The phenotypes of double mutants, the coprecipitation of Rvs161p and Fus2p, and the fact that the stability of Fus2p was strongly dependent on Rvs161p's mating function lead to the conclusion that Rvs161p is required to interact with Fus2p for efficient cell fusion.
The economy of parallel and distributed computing in the cloud

Large-scale simulation and analysis software is used heavily in the VLSI industry. One would naturally think that it's a job for HPC. However, the cost of such clusters and the existing pricing model of commercially available software packages lead to some interesting tradeoffs and business models. We propose the use of cloud computing and a corresponding pricing model that directly relates to the amount of computing accomplished. This should promote better utilization of both hardware and energy in using such software.
Extended self-similarity in turbulent flows.

We report on the existence of a hitherto undetected form of self-similarity, which we call extended self-similarity (ESS). ESS holds at high as well as at low Reynolds number, and it is characterized by the same scaling exponents of the velocity differences of fully developed turbulence.
Conservation and Periodicity of DNA Bend Sites in the Human β-Globin Gene Locus (*)

A total of seven DNA bend sites were mapped in the 4.4-kilobase human β-globin gene region by the circular permutation assay. The periodicity of these sites (except one) was about every 700 (average 685.5 ± 267.7) base pairs. All of the sites contained the sequence feature of short poly(dA) tracts, which are typical of DNA bending. The relative positions of the sites to the cap site were identical to those in the ε-globin gene region, suggesting that the bend sites were conserved during molecular evolution of the two globin genes. To explain this periodicity and conservation of the sites within the evolutionary unstable noncoding regions, we focused upon the appearance of a potential bend core sequence, A2N8A2N8A2 (A/A/A), and its complement, T2N8T2N8T2 (T/T/T). These sequences appeared in or very close to most of the bend sites of the globin gene regions, whereas other A+T-rich sequences or candidates for DNA bending did not. The distances between any two of the core sequences in the entire β-globin locus showed a strong bias to a length of about 700 base pairs and its multiples, suggesting that the periodicity exists throughout the locus. The data presented here strengthen the idea of sequence-directed nucleosome phasing.
Cut-Off Values of Visceral Adiposity to Predict NAFLD in Brazilian Obese Adolescents

Objectives. The present study aimed at determining cut-off points of visceral fat to predict NAFLD and analyzed metabolic disorders of obese adolescents. Methods. Cross-sectional study involved 165 obese adolescents ranged in age from 15 to 19 years. Glycemia, hepatic transaminases, lipid profile, and insulin resistance were analyzed. Visceral and subcutaneous fat were measured by ultrasound and body composition by plesthysmography. Results. The NAFLD adolescents had significantly higher values for body mass, BMI-for-age, BMI, total fat, waist circumference, and visceral fat when compared with non-NAFLD obese adolescents in both genders. Moreover, there were significant positive correlations between visceral fat with the variables BMI-for-age (r = 0.325,), TG (r = 0.277), AST (r = 0.509), ALT (r = 0.519), WC (r = 0.390), and visceral/subcutaneous ratio (r = 0.790) for NAFLD group. Total fat, triglycerides, and visceral fat were the independent predictors to NAFLD. Analysis of the ROC curves revealed cut-off points of visceral fat of 4.47 cm for girls and 4.21 cm for boys. Conclusions. The results may suggest that abdominal ultrasonography procedure may be a safe alternative method of assessing visceral adiposity aiming to be considered to the development of preventive and treatment strategies in obese individuals. This clinial trial is registered with ClinicalTrial.gov (NCT01358773).
Discovering, Analyzing and Enhancing BPMN Models Using ProM

Process mining techniques relate observed behavior to modeled be- havior, e.g., the automatic discovery of a process model based on an event log. Process mining is not limited to process discovery and also includes conformance checking and model enhancement. Conformance checking techniques are used to diagnose the deviations of the observed behavior as recorded in the event log from some process model. Model enhancement allows to extend process models us- ing additional perspectives, conformance and performance information. In recent years, BPMN (Business Process Model and Notation) 2.0 has become a de facto standard for modeling business processes in industry. This paper presents the BPMN support current in ProM. ProM is the most known and used open-source process mining framework. ProM's functionalities of discovering, analyzing and enhancing BPMN models are discussed. Support of the BPMN 2.0 standard will help ProM users to bridge the gap between formal models (such as Petri nets, causal nets and others) and process models used by practitioners.
DETERMINATION OF STELLAR RADII FROM ASTEROSEISMIC DATA

The NASA Kepler mission is designed to find planets through transits. Accurate and precise radii of the detected planets depend on knowing the radius of the host star accurately, which is difficult unless the temperature and luminosity of the star are known precisely. Kepler, however, has an asteroseismology program that will provide seismic variables that can characterize stellar radii easily, accurately, and extremely precisely. In this paper, we describe the Yale–Birmingham (YB) method to determine stellar radii using a combination of seismic and conventional variables and analyze the effect of these variables on the result. We find that for main-sequence stars, a knowledge of the parallax is not important to get accurate radii using the YB method: we can get results to an accuracy and precision of better than a few percent if we know the effective temperature and the seismic parameters for these stars. Metallicity does not make much difference either. However, good estimates of the effective temperature and metallicity, along with those of the seismic parameters, are essential to determine radii of subgiants properly. On the other hand, for red giants we find that determining radii properly is not possible without a good estimate of the parallax. We find that the so-called “surface term” in the seismic data has minimal effect on the inferred radii. Uncertainties in the convective mixing length can matter under some circumstances and can cause a systematic shift in the inferred radii. Blind tests with data simulated to match those expected from the asteroseismic survey phase of Kepler show that it will be possible to infer stellar radii successfully using our method.
CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case–control study within a large‐scale population‐based prospective study

Cytochrome P450 (CYP) 1A1 and glutathione S‐transferases (GST) M1 and T1 are major enzymes in the carcinogen metabolizing pathway. We examined the association between single nucleotide polymorphisms (SNPs) of CYP1A1 (rs4646421, rs4646422 and rs1048943), GSTM1 and GSTT1 and gastric cancer risk in Japan. This is a nested case–control study (457 cases and 457 matched controls) of our population‐based cohort involving 36,745 subjects who answered a baseline questionnaire and supplied blood samples. The odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated using conditional logistic regression models. We found that CYP1A1 (rs4646422) variant allele was associated with a statistically significant increased risk of gastric cancer compared with the homozygous wild‐type genotype (OR = 1.65; 95% CI = 1.17–2.32). GSTM1 null, GSTT1 null and GSTM1/T1 both or either null genotypes were associated with increased risk, but not statistically significantly. Combination of the CYP1A1 (rs4646422) variant allele and GSTM1/T1 both or either null genotypes was associated with a statistically significant increased risk compared with the combination of the CYP1A1 homozygous wild‐type genotype and the GSTM1/T1 both active genotypes. In addition, compared with CYP1A1 (rs4646422) homozygous wild‐type genotypes in those who were never‐smokers, CYP1A1 variant alleles in those who smoked ≥30 pack‐years were associated with an increased risk; neither gene–gene nor gene–environment interactions were significant. The CYP1A1 (rs4646422) polymorphism might be involved in gastric carcinogenesis among the Japanese population.
Surface Plasmon Resonance-Based Fiber Optic Sensors Utilizing Molecular Imprinting

Molecular imprinting is earning worldwide attention from researchers in the field of sensing and diagnostic applications, due to its properties of inevitable specific affinity for the template molecule. The fabrication of complementary template imprints allows this technique to achieve high selectivity for the analyte to be sensed. Sensors incorporating this technique along with surface plasmon or localized surface plasmon resonance (SPR/LSPR) provide highly sensitive real time detection with quick response times. Unfolding these techniques with optical fiber provide the additional advantages of miniaturized probes with ease of handling, online monitoring and remote sensing. In this review a summary of optical fiber sensors using the combined approaches of molecularly imprinted polymer (MIP) and the SPR/LSPR technique is discussed. An overview of the fundamentals of SPR/LSPR implementation on optical fiber is provided. The review also covers the molecular imprinting technology (MIT) with its elementary study, synthesis procedures and its applications for chemical and biological anlayte detection with different sensing methods. In conclusion, we explore the advantages, challenges and the future perspectives of developing highly sensitive and selective methods for the detection of analytes utilizing MIT with the SPR/LSPR phenomenon on optical fiber platforms.
History of the Use of Antidepressants in Primary Care

From Jefferson Medical College, Hockessin, Del. Supported by funding from Wyeth Pharmaceuticals, Philadelphia, Pa. Dr. Lieberman serves as a consultant to Abbott, Cephalon, Bristol-Myers, Forest, Janssen, Lilly, Novartis, Organon, Novo Nordisk, Pfizer, Ortho-McNeil, and Sanofi-Synthelabo. Corresponding author and reprints: Joseph A. Lieberman III, M.D., M.P.H. , Jefferson Medical College, 2 Aston Circle, Hockessin, DE 19707-2500 (e-mail: jlieberman@jalmd.com). History of the Use of Antidepressants in Primary Care
Integrated transversal equalizers in high-speed fiber-optic systems

Intersymbol interference (ISI) caused by intermodal dispersion in multimode fibers is the major limiting factor in the achievable data rate or transmission distance in high-speed multimode fiber-optic links for local area networks applications. Compared with optical-domain and other electrical-domain dispersion compensation methods, equalization with transversal filters based on distributed circuit techniques presents a cost-effective and low-power solution. The design of integrated distributed transversal equalizers is described in detail with focus on delay lines and gain stages. This seven-tap distributed transversal equalizer prototype has been implemented in a commercial 0.18-/spl mu/m SiGe BiCMOS process for 10-Gb/s multimode fiber-optic links. A seven-tap distributed transversal equalizer reduces the ISI of a 10-Gb/s signal after 800 m of 50-/spl mu/m multimode fiber from 5 to 1.38 dB, and improves the bit-error rate from about 10/sup -5/ to less than 10/sup -12/.
Number of Persons With Symptomatic Knee Osteoarthritis in the US: Impact of Race and Ethnicity, Age, Sex, and Obesity

The prevalence of symptomatic knee osteoarthritis (OA) has been increasing over the past several decades in the US, concurrent with an aging population and the growing obesity epidemic. We quantify the impact of these factors on the number of persons with symptomatic knee OA in the early decades of the 21st century.
Impact of Different Creatinine Measurement Methods on Liver Transplant Allocation

Introduction The model for end-stage liver disease (MELD) score is used in many countries to prioritize organ allocation for the majority of patients who require orthotopic liver transplantation. This score is calculated based on the following laboratory parameters: creatinine, bilirubin and the international normalized ratio (INR). Consequently, high measurement accuracy is essential for equitable and fair organ allocation. For serum creatinine measurements, the Jaffé method and enzymatic detection are well-established routine diagnostic tests. Methods A total of 1,013 samples from 445 patients on the waiting list or in evaluation for liver transplantation were measured using both creatinine methods from November 2012 to September 2013 at the university hospital Leipzig, Germany. The measurements were performed in parallel according to the manufacturer’s instructions after the samples arrived at the institute of laboratory medicine. Patients who had required renal replacement therapy twice in the previous week were excluded from analyses. Results Despite the good correlation between the results of both creatinine quantification methods, relevant differences were observed, which led to different MELD scores. The Jaffé measurement led to greater MELD score in 163/1,013 (16.1%) samples with differences of up to 4 points in one patient, whereas differences of up to 2 points were identified in 15/1,013 (1.5%) samples using the enzymatic assay. Overall, 50/152 (32.9%) patients with MELD scores >20 had higher scores when the Jaffé method was used. Discussion Using the Jaffé method to measure creatinine levels in samples from patients who require liver transplantation may lead to a systematic preference in organ allocation. In this study, the differences were particularly pronounced in samples with MELD scores >20, which has clinical relevance in the context of urgency of transplantation. These data suggest that official recommendations are needed to determine which laboratory diagnostic methods should be used when calculating MELD scores.
Cyclic Lipodepsipeptides Produced by Pseudomonas spp. Naturally Present in Raw Milk Induce Inhibitory Effects on Microbiological Inhibitor Assays for Antibiotic Residue Screening

Two Pseudomonas strains, identified as closely related to Pseudomonas tolaasii, were isolated from milk of a farm with frequent false-positive Delvotest results for screening putative antibiotic residues in raw milk executed as part of the regulatory quality programme. Growth at 5 to 7°C of these isolates in milk resulted in high lipolysis and the production of bacterial inhibitors. The two main bacterial inhibitors have a molecular weight of 1168.7 and 1140.7 Da respectively, are heat-tolerant and inhibit Geobacillus stearothermophilus var. calidolactis, the test strain of most of the commercially available microbiological inhibitor tests for screening of antibiotic residues in milk. Furthermore, these bacterial inhibitors show antimicrobial activity against Staphylococcus aureus, Bacillus cereus and B. subtilis and also interfere negatively with yoghurt production. Following their isolation and purification with RP-HPLC, the inhibitors were identified by NMR analysis as cyclic lipodepsipeptides of the viscosin group. Our findings bring to light a new challenge for quality control in the dairy industry. By prolonging the refrigerated storage of raw milk, the keeping quality of milk is influenced by growth and metabolic activities of psychrotrophic bacteria such as pseudomonads. Besides an increased risk of possible spoilage of long shelf-life milk, the production at low temperature of natural bacterial inhibitors may also result in false-positive results for antibiotic residue screening tests based on microbial inhibitor assays thus leading to undue production loss.
Temperament and character properties of male psoriasis patients

Personality properties have an effect on the onset and triggering of psoriasis. The current study aimed to examine the personality of psoriasis patients in relation to the severity of the illness. Psoriasis and healthy participants completed the Beck Depression Inventory, Beck Anxiety Inventory, Maudsley Obsessive Compulsive Inventory, Temperament and Character Inventory. Severity of psoriasis was evaluated by the PASI. MANCOVA results revealed significantly higher Novelty Seeking, Harm Avoidance, Reward Dependence and Self-Transcendence scores for psoriasis group. Severity of PASI was predicted by harm avoidance and reward dependence. Personality properties should be evaluated while planning therapeutic interventions for psoriasis patients.