Miracle-dz/UniFAR-FTUs huggingface dataset:
Cell-mediated immunity to micro-organisms in rheumatoid arthritis.

localized osteochondritis. Is there any similarity between these lesions and those that occur in young people without ankylosing spondylitis? DR. CAWLEY Although we have no examples of the histology of osteochondritic lesions in non-spondylitics, Schmorl (1959) showed these lesions to consist of a herniation of the disc into the vertebral body. Radiologically and pathologically both our localized lesions and spinal osteochondritis probably represent such discal herniation.
Giant Cerebral Aneurysms: Endovascular Challenges

OBJECTIVE:Giant (≥25 mm in diameter) cerebral aneurysms have a poor natural history, with high risks of subarachnoid hemorrhage or progressive disability or death caused by mass effect or stroke. Surgical treatment may be effective but carries a high burden of morbidity and mortality. Thus, attempts at endovascular solutions to these complex lesions have been developed to offer therapy at reduced risk. METHODS:The authors reviewed their clinical experience and the current body of literature concerning giant cerebral aneurysms and present their perspective on the current state of the art in endovascular therapy for these aneurysms. A variety of techniques are described that can be used in an attempt to provide a solution to the wide variety of clinical dilemmas associated with the management of these difficult lesions. Preprocedural planning and periprocedural considerations are discussed briefly. The use of intracranial balloons and stents are described in conjunction with the use of detachable platinum coils. The developing concept of using stents alone to treat aneurysms is discussed. Alternative methods of treating giant aneurysms are discussed. RESULTS:Current endovascular approaches, when properly selected and applied, can provide lower-risk therapies than conventional microsurgical approaches for patients harboring giant cerebral aneurysms. However, endovascular approaches do not, at present, provide results that are as durable as current surgical techniques for giant cerebral aneurysms. CONCLUSION:Treatment of giant cerebral aneurysms via endovascular therapeutics requires the interventionist to possess an extensive armamentarium. Meticulous preprocedure evaluation, patient selection, and execution of the treatment plan enable safe and effective management. Current therapies do not provide an ideal solution for every patient, so one must consider creative and evolving solutions to these difficult clinical challenges. The procedural morbidity of open surgery versus the decreased durability of current endovascular techniques must be assessed carefully.
Evaluation of Project Critical Success Factors for Key Construction Players and Objectives

Critical Success Factors (CSFs) are used to support and evaluate the success of a strategic and tactical approach in project implementation in order to increase the probability of success. This system is used by executors in project delivery to achieve improved performance capabilities with limited resources. The present paper aims to identify the impact of CSFs amongst the main elements involved in construction industry of projects in Iran (Owner, Contractor, and Consultant). Therefore, 41 CSFs-related indices based on present research conditions in Iran were selected and classified into five major categories: (1) Financial, (2) Interactive Processes, (3) Human Resources, (4) Contractual Arrangements, and (5) Project Characteristics. To analyze the CSFs of project, the required data were collected by questionnaire based on randomized sampling method by project managers, chief executive officers, and experts of construction industry of Owners, Contractors, and Consultant who have working experience in major projects in Iran. The results indicated that indices related to human resources group from the point of view of Owners and Contractors as well as the indices related to financial and project participants from the point of view of Consultant are the main success priorities in projects. Moreover, the indices of “adequacy of plans and specifications” and “Project manager competency” were elected indices common in previous and present studies. The results of this study will provide the project managers with practical solutions in order to benefit the findings as guidelines for CSFs formation according to Construction projects in Iran.
Channel training procedures for MIMO interfering point-to-multipoint channel

A precise knowledge of the MIMO channel between the serving node and the user equipment (UE) is important for attaining good data rates in downlink transmissions (DL) in cellular systems. The interfering point-to-multipoint (I-P2MP) channel, consisting of multiple transmitters coexisting in the same area, where each transmitter is intended to serve multiple users, is a model that subsumes most of the scenarios that can be found in wireless cellular networks with a dense deployment of small cells (SCs). In conventional channel estimation procedures, resources allocated to each SC for training tend to be orthogonal, negatively impacting in the efficiency of the whole system. Reusing resources for training allows releasing resources for data transmission, but at the cost of degrading the channel estimation due to interference. We propose a decentralized algorithm for interference management that enforces the coordination among SCs in the design of the training sequences for de DL. Results in this work elucidate how to reuse resources for training and significantly improve the throughput of the system.
FPGA Prototyping and Design Evaluation of a NoC-Based MPSoC

Chip communication architectures become an important element that is critical to control when designing a complex MultiProcessor System-on-Chip (MPSoC). This led to the emergence of new interconnection architectures, like Network-on-Chip (NoC). NoCs have been proven to be a promising solution to the concerns of MPSoCs in terms of data parallelism. Field-Programmable Gate Arrays (FPGA) has some perceived challenges. Overcoming those challenges with the right prototyping solutions is easy and cost-effective leading to much faster time-to-market. In this paper, we present an FPGA based on rapid prototyping in hardware/software co-design and design evaluation of a mixed HW/SW MPSoC using a NoC. A case study of two-dimensional mesh NoC-based MPSoC architecture is presented with a validation environment. The synthesis and implementation results of the NoC-based MPSoC on a Virtex 5 ML 507 enable a reasonable frequency (151.5 MHz) and a resource usage rate equals to 58% (6,586 out of 11,200 slices used).
KDAC8 substrate specificity quantified by a biologically relevant, label‐free deacetylation assay

Analysis of the human proteome has identified thousands of unique protein sequences that contain acetylated lysine residues in vivo. These modifications regulate a variety of biological processes and are reversed by the lysine deacetylase (KDAC) family of enzymes. Despite the known prevalence and importance of acetylation, the details of KDAC substrate recognition are not well understood. While several methods have been developed to monitor protein deacetylation, none are particularly suited for identifying enzyme‐substrate pairs of label‐free substrates across the entire family of lysine deacetylases. Here, we present a fluorescamine‐based assay which is more biologically relevant than existing methods and amenable to probing substrate specificity. Using this assay, we evaluated the activity of KDAC8 and other lysine deacetylases, including a sirtuin, for several peptides derived from known acetylated proteins. KDAC8 showed clear preferences for some peptides over others, indicating that the residues immediately surrounding the acetylated lysine play an important role in substrate specificity. Steady‐state kinetics suggest that the sequence surrounding the acetylated lysine affects binding affinity and catalytic rate independently. Our results provide direct evidence that potential KDAC8 substrates previously identified through cell based experiments can be directly deacetylated by KDAC8. Conversely, the data from this assay did not correlate well with predictions from previous screens for KDAC8 substrates using less biologically relevant substrates and assay conditions. Combining results from our assay with mass spectrometry‐based experiments and cell‐based experiments will allow the identification of specific KDAC‐substrate pairs and lead to a better understanding of the biological consequences of these interactions.
A market for ideas intermediator framework for academic spin-off companies: expanding understanding of the commercialization of technology

ABSTRACT Academic spin-off companies have attracted the attention of public policy, universities, and research technology organizations as the most effective mechanism for research commercialization and technology transfer from research institutions and universities. Spin-offs can be considered intermediators in the market for ideas as spin-off development models may contemplate mergers and acquisitions with established companies. This paper follows a mixed method approach and explores both primary and secondary data, as well as the complementarity of two analytical units (academic spin-off case studies and technology assessment discussions) in an action-based study with different research groups to capture the pre-spin-off stage rationale. The paper proposes a framework to describe the micro-foundations of the generation of academic spin-offs. Considering the concepts of technology intermediation, the framework contextualizes the market for ideas and takes a process view of innovation. The fragmented and distributed R&D chain provides insight into efficiency in technology and technological knowledge commercialization.
Age effects in kyphosis and lordosis in adults.

SummaryA surveyor's flexicurve has been used to measure kyphosis and lordosis in a cross-sectional study of men and women aged 20–90 years. No age effect was found in men aged 20–59 years or in women aged 20–49 years. Linear regressions showed an increase in kyphosis with age in older men and women. Various indices were examined to test their suitability as estimates of kyphosis. Lordosis was absent in an increasingly large proportion of men and women as age rose above 60 years.
Logger perceptions of salvage harvesting in Minnesota, USA

ABSTRACT Harvesting timber in forests recently affected by a disturbance, i.e. in salvage conditions, is generally thought to take longer and come at a greater cost compared to harvesting non-salvage timber. Despite this, the degree that forest disturbances create stand conditions that impact productivity when harvesting salvage timber has not been quantified. Similarly, the concerns and perceptions loggers have when operating in salvage conditions have not been fully assessed. This analysis examined mailed survey responses from 129 logging business owners from the state of Minnesota, USA, which inquired about their experience in harvesting timber from salvage sales, concerns about operating under salvage conditions, and perceptions of productivity in forests impacted by three common disturbances. In total, 41.9% of logging business owners (n = 54) indicated they harvested wood from at least one salvage sale in 2015 or 2016. The majority of loggers cited concerns with reduced productivity and reduced wood quality when operating under salvage conditions. Using multinomial logistic regression, analyses indicate logging business owners would have a greater probability of conducting a salvage sale if they produced more volume, were in business for fewer years, and produced a greater percentage of volume during the summer months. As managing for natural disturbances are increasingly being incorporated into forest management plans, forestry professionals should consider these results in response to relatively discrete disturbance events and how salvage sales are designed.
Comparison between high-T/sub c/ superconducting microstrip filters and normal conducting counterparts

In this paper the comparative study of HTS microstrip filter and gold counterpart is reported in terms of insertion loss, transmission characteristics, bandwidth and other various characteristics. Practically full procedures from the preparation of each thin films to fabrication procedure of each devices and experimental results are given for both HTS microstrip filter and gold counterpart. The filters used in this work, were based on the use of non-uniform microstrip line type, which is a stepped impedance resonator as a filter element. The superconducting microstrip filter used in this work was fabricated on MgO substrates using YBCO (YBa/sub 2/Cu/sub 3/O/sub 7-x/) superconducting thin films by pulsed laser deposition technique and also, the gold filter with the same dimensions was fabricated on the same substrate by thermal evaporation technique. Then gold thin films of the same thickness were evaporated on the other sides of each filter for the ground plane. Comparison results between HTS filter and gold filter show that a usable filter can be made by using this architecture.
ParkedGuard: An Efficient and Accurate Parked Domain Detection System Using Graphical Locality Analysis and Coarse-To-Fine Strategy

As world wild internet has non-stop developments, making profit by lending registered domain names emerges as a new business in recent years. Unfortunately, the larger the market scale of domain lending service becomes, the riskier that there exist malicious behaviors or malwares hiding behind parked domains will be. Also, previous work for differentiating parked domain suffers two main defects: 1) too much data-collecting effort and CPU latency needed for features engineering and 2) ineffectiveness when detecting parked domains containing external links that are usually abused by hackers, e.g., drive-by download attack. Aiming for alleviating above defects without sacrificing practical usability, this paper proposes ParkedGuard as an efficient and accurate parked domain detector. Several scripting behavioral features were analyzed, while those with special statistical significance are adopted in ParkedGuard to make feature engineering much more cost-efficient. On the other hand, finding memberships between external links and parked domains was modeled as a graph mining problem, and a coarse-to-fine strategy was elaborately designed by leverage the graphical locality such that ParkedGuard outperforms the state-of-the-art in terms of both recall and precision rates. Keywords—Coarse-to-fine strategy, domain parking service, graphical locality analysis, parked domain.
The fine structure of coelomocytes in the annelid Enchytraeus fragmentosus

Two types of coelomocytes, the mucocyte and the phagocyte, occur in Enchytraeus fragmentosus. Other free cells observed within the coelomic cavity include chloragogen cells, peritoneal cells and some anucleate granular cells. Three forms of mucocytes occur and are believed to represent developmental stages. The first stage is one in which the mucous droplets are forming in the Golgi region. The second stage is a mature form, and the third stage is one in which the mucous droplets are being released. The phagocytes generally are quite large, and inclusions vary from recognizable portions of chloragogen cells to extremely small, electron‐dense cytosomes. The origin of the coelomocytes could not be determined. Probable functions of coelomocytes are discussed.
Simple Clinical Hearing-tests for Very Young or Mentally Retarded Children

We should like to express our thanks to the Medical Research Council, who supported this work; also to the Director and his staff at the Road Research Laboratory of the Department of Scientific and Industrial Research, who provided us with accommodation, subjects, and much of the apparatus, and who were unfailing in their help and advice. We are indebted to Mr. E. B. Parkes, the Director of the S.W. Forensic Science Laboratory, and to Mr. K. Jones, of that laboratory, for their help in the analysis of body fluids carried out by Mrs. A. Myers.
Designing the Composition of Amorphous Free Layer of a Magnetic Tunnel Junction

The magnetic and thermal properties of Co<sub>70.5</sub>Fe<sub>4.5</sub>Si1<sub>5</sub>B<sub>10</sub> and Ni<sub>16</sub>Fe<sub>62</sub>Si<sub>8</sub>B<sub>14</sub> quaternary amorphous alloys (metallic glasses) used for a free layer in the magnetic tunnel junctions (MTJs) were studied to correlate magnetic and glass characterization of amorphous alloys and the performance of the MTJs with amorphous free layer. The characteristics of these amorphous free layers were compared with crystalline free layers composed of Co<sub>90</sub>Fe<sub>10</sub> and Ni<sub>20</sub>Fe<sub>80</sub> and other ternary amorphous alloys composed of Co<sub>60</sub>Fe<sub>20</sub>B<sub>20</sub>, and Co<sub>24</sub>Fe<sub>56</sub>B<sub>20</sub>. Results based on X-ray diffraction, vibrating sample magnetometer (VSM), and differential scanning calorimetry (DSC) were presented. The amorphous alloys exhibit the soft magnetic properties of low saturated magnetization (M<sub>s</sub>) and low coercivity (H<sub>c</sub>) in hyeteresis loops. The thermal properties were represented by the values of glass transition temperature (T<sub>g</sub>), curie temperature (T<sub>c</sub>), crystallization temperature (T<sub>x</sub>), melting temperature (T<sub>m</sub>), T<sub>rg</sub> (defined as T<sub>g</sub>/T<sub>m</sub>), and DeltaT<sub>x</sub> (defined as T<sub>x</sub>-T<sub>g</sub> ). Compared with the other alloys, the amorphous Co<sub>70.5</sub>Fe<sub>4.5</sub>Si<sub>15</sub>B<sub>10</sub> alloy exhibits low M<sub>s</sub>, and low saturated field (H<sub>s</sub>). This alloy also shows estimated high T<sub>g</sub>, large DeltaT<sub>x</sub>, and high T<sub>rg</sub>. Correlations between magnetic and glass characterization of amorphous free layer and the properties of MTJs composed of amorphous free layer were discussed.
Taurine activates glycine and &ggr;-aminobutyric acid A receptors in rat substantia gelatinosa neurons

Taurine has been suggested to modulate nociceptive information at the spinal cord level. In this study, the pharmacological properties of taurine were investigated in adult rat substantia gelatinosa (SG) neurons using whole-cell patch-clamp method. We found that taurine seemed to have higher efficacy than glycine on glycine receptors in SG neurons. An increase in chloride conductance was responsible for taurine-induced currents. Taurine at 0.3 mM activated glycine receptors, whereas at 3 mM activated both glycine and &ggr;-aminobutyric acid A receptors. The currents activated by coapplication of taurine and glycine are cross inhibitive. Altogether these results show that taurine might represent another important neurotransmitter or modulator in SG neurons, which may be involved in antinociception.
Core–shell polymer nanorods by a two-step template wetting process

One-dimensional core–shell polymer nanowires offer many advantages and great potential for many different applications. In this paper we introduce a highly versatile two-step template wetting process to fabricate two-component core–shell polymer nanowires with controllable shell thickness. PLLA and PMMA were chosen as model polymers to demonstrate the feasibility of this process. Solution wetting with different concentrations of polymer solutions was used to fabricate the shell layer and melt wetting was used to fill the shell with the core polymer. The shell thickness was analyzed as a function of the polymer solution concentration and viscosity, and the core–shell morphology was observed with TEM. This paper demonstrates the feasibility of fabricating polymer core–shell nanostructures using our two-step template wetting process and opens the arena for optimization and future experiments with polymers that are desirable for specific applications.
Decision trees using synchronized phasor measurements for wide-area response-based control

This paper proposes using phasor measurement unit (PMU) data to trigger one-shot control in response to loss of synchronism detection. Decision trees (DTs) are trained to associate voltage magnitude and angle measurements with loss of synchronism. Different approaches to the DT construction process are illustrated in an early section of the paper by restricting the input vector to only two elements. Response-based control is obtained by triggering one-shot control the first time the DT classifies measurements as “Unstable”. The same combination of one-shot controls is applied to any event the first time the DT outputs “Unstable”. The method is demonstrated on a 176-bus reduced-order model of the western U.S. interconnection. An effective one-shot control consists of a combination of fast power changes on four buses. This control is similar to 500-MW fast power increases on two HVDC interties and it reduces angle differences in the AC network.
Imprecision in Accounting Measurement: Can it Be Value Enhancing?

Accounting measurements of firms' investments are usually imprecise. We study the economic consequences of such imprecision when it interacts with information asymmetry regarding an investment project's ex ante profitability, known only by the firm's managers. Absent agency and risk-sharing considerations, we find that some degree of accounting imprecision could actually be value enhancing. We characterize the optimal degree of imprecision and identify its key determinants. The greater the information asymmetry regarding the project's profitability, the greater is the imprecision that should be tolerated in the measurement of the firm's investment. Copyright 2005 The Institute of Professional Accounting, University of Chicago.
The future evolution of relationship marketing

The purpose of this chapter is to review the forces that led to the spectacular rise of relationship marketing both as a marketing practice and as a discipline. More importantly, I will suggest how relationship marketing is likely to evolve in the future. The fundamental force behind the rise of relationship marketing was the economic recession of the early 1980s caused by the first energy crisis of the 1970s (1974–78). This is often referred to as stagflation (inflation without economic growth). Both the monetary policy of high interest rates to curb inflation and the fiscal policy of wholesale deregulation of infrastructure industries such as airlines and trucking to stimulate growth during the Carter administration failed. This was followed by the Reagan administration’s focus on the global competitiveness of U.S. industries. It led to lowering the corporate tax rate and establishing the Malcolm Baldrige Quality Awards in manufacturing and services industries. The Reagan administration also allowed megamergers of directly competitive businesses. For example, General Electric (GE) was allowed to buy RCA in the consumer electronics industry, and similar mergers and acquisitions were allowed in the beer, soft drinks, aviation, and defense industries. The fundamental impact of this exogenous macroeconomic reality was to shift the marketing objective from organically gaining market share to acquiring market share through mergers and acquisitions. The vast amount of prior research which empirically validated the prevailing view (on what was referred to as PIMS database research) that the financial performance of a product or a company was directly related to its marketing plans, including segmentation, positioning, and targeting (SPT) to gain market share, was now questioned. Return on marketing investment (RoMI) could not be justified, especially based on economic value added (EVA) and activity based costing (ABC). The best ways, therefore, to gain market share were inorganic growth such as mergers, acquisitions, and alliances. This was further reinforced with the growth of private equity companies such as KKR and