Miracle-dz/UniFAR-FTUs huggingface dataset:
Hybrid precoding with compressive sensing based limited feedback in massive MIMO systems

Massive multiple‐input multiple‐output (MIMO) systems are an enabling technology for high capacity 5G cellular networks. However, the high hardware complexity and power consumption make it difficult to apply conventional MIMO precoding schemes in massive MIMO. Additionally, thanks to the large channel dimension, applying traditional limited feedback schemes for obtaining channel state information at the transmitter is a challenge. In this paper, we develop a low‐complexity hybrid precoding scheme for multiuser massive MIMO system in mmWave communication. We design the analog beamformer as the conjugate transpose of the downlink channel from base station to the users. Then zero‐forcing baseband processing is applied over the effective channel. We get the optimal power allocation policy and compare its performance with average power allocation based on channel state information at transmitter. The channel state information at transmitter is obtained via a compressive sensing based limited feedback strategy. The effectiveness of hybrid precoding relies on the feedback quality of channel state information, which relies on the compression ratio. We quantify the impact of compression ratio on precoder performance and derive an upper bound on the sum rate. Simulation results illustrate the performance of our proposed scheme and the effect of compressive sensing based limited feedback.
Human Wharton's Jelly Stem Cells and Its Conditioned Medium Enhance Healing of Excisional and Diabetic Wounds

Wound healing is a major problem in diabetic patients and current treatments have met with limited success. We evaluated the treatment of excisional and diabetic wounds using a stem cell isolated from the human umbilical cord Wharton's jelly (hWJSC) that shares unique properties with embryonic and adult mesenchymal stem cells. hWJSCs are non‐controversial, available in abundance, hypo‐immunogenic, non‐tumorigenic, differentiate into keratinocytes, and secrete important molecules for tissue repair. When human skin fibroblasts (CCD) in conventional scratch‐wound assays were exposed to hWJSC‐conditioned medium (hWJSC‐CM) the fibroblasts at the wound edges migrated and completely covered the spaces by day 2 compared to controls. The number of invaded cells, cell viability, total collagen, elastin, and fibronectin levels were significantly greater in the hWJSC‐CM treatment arm compared to controls (P < 0.05). When a single application of green fluorescent protein (GFP)‐labeled hWJSCs (GFP‐hWJSCs) or hWJSC‐CM was administered to full‐thickness murine excisional and diabetic wounds, healing rates were significantly greater compared to controls (P < 0.05). Wound biopsies collected at various time points showed the presence of green GFP‐labeled hWJSCs, positive human keratinocyte markers (cytokeratin, involucrin, filaggrin) and expression of ICAM‐1, TIMP‐1, and VEGF‐A. On histology, the GFP‐hWJSCs and hWJSC‐CM treated wounds showed reepithelialization, increased vascularity and cellular density and increased sebaceous gland and hair follicle numbers compared to controls. hWJSCs showed increased expression of several miRNAs associated with wound healing compared to CCDs. Our studies demonstrated that hWJSCs enhance healing of excisional and diabetic wounds via differentiation into keratinocytes and release of important molecules. J. Cell. Biochem. 115: 290–302, 2014. © 2013 Wiley Periodicals, Inc.
Research on a new hybrid intelligent fault diagnosis method and its application

In order to overcome the shortcomings of slow convergence speed and easy falling into the local minimum values of the BP neural network, an improved particle swarm optimization(PSO) algorithm is proposed to optimize the redial basic function (RBF) neural network, in order to propose a new hybrid intelligent fault diagnosis(IMPSORBFNN) method. In the IMPSO-RBFNN method, the adaptive dynamic adjusting strategy is used to control the inertia weight of the PSO algorithm in order to an improved particle swarm optimization(IMPSO) algorithm. Then the IMPSO algorithm is selected to optimize the parameters of RBF neural network by encoding the particle and continuous iteration of the IMPSO algorithm in order to obtain the optimal combination values of the parameters of RBF neural network. The optimal combination values are regarded as the values of these parameters of the RBFNN for constructing the final IMPSO-RBFNN method. In order to test the effectiveness of the proposed IMPSO-RBFNN method, the data from bearing data center of CWRU is selected in this paper. The experiment results show that the IMPSO algorithm can effectively optimize the weights of RBFNN, the IMPSO-RBFNN method can accurately realize high precision fault diagnosis of rolling bearing.
Effects of Subchronic Exposures to Concentrated Ambient Particles (CAPs) in Mice: II. The Design of a CAPs Exposure System for Biometric Telemetry Monitoring

Abstract We modified, assembled, tested, and validated the versatile aerosol concentration enrichment system (VACES) developed by for use in a subchronic experiment that involved exposures of mice in vivo and of respiratory epithelial cells in vitro to concentrated ambient particles (CAPs). Since the labor-intensive nose-only exposure regimen is not an option in a long-term experiment, a whole-body exposure mouse chamber was designed specifically for use with the VACES. The exposure system consists of a stainless-steel (SS) tub with 32 cubicles (1 mouse per cubicle) separated by perforated SS sheets. The tops of these cubicles are covered with perforated plastic sheets to allow telemetry monitoring during the exposure. In each exposure chamber, perforated aluminum tubes are used to distribute CAPs evenly (within 2% difference) throughout the exposure chamber. The exhaust consists of perforated aluminum tubes covered with a urine shield. The modification to the original design of the VACES facilitated the operation of the system in a subchronic study. Mass flow controllers maintain a constant flow rate into the exposure chambers. For a sham control exposure, the identical system is used, except that a HEPA filter at the inlet to the VACES removes 98% of ambient particles. The entire system allows for simultaneous exposure of 64 mice to CAPs, with an equal number of sham-exposed mice as controls. Telemetry receivers have been modified so that 16 mice per group with electrocardiograph (EKG) transmitters can be monitored during exposure. Furthermore, a BioSampler is used to collect CAPs (one sample per day) for the in vitro exposures. In this article, the assessments of flow and particle distribution of the exposure chamber as well as the performance of the system during the subchronic exposure experiment are described.
V‐sis induces Egr‐1 expression by a pathway mediated by c‐Ha‐ras

The early growth response gene, Egr‐1, is up‐regulated transiently by mitogens and many other simuli in all cells tested. Using NIH3T3 cells conditionally expressing v‐sis from a metallothionein promoter, we show that the addition of Zn2+ stimulates the production of PDGF‐B(v‐sis) and elicits the expression of Egr‐1 in a dose‐dependent and time‐regulated manner. The signal is likely independent of protein kinase C, but depends on tyrosine kinase and other kinase activities and is mediated by c‐Ha‐Ras since the presence of dominant‐negative mutants of Ras and Raf abrogates the induction of Egr‐1 expression by Zn2+. Transiently activated Ras expression in NIH3T3 cells also stimulates the transient expression of Egr‐1, but cells that constitutively express Rass do not have elevated levels of Egr‐1. Transient assays also demonstrated that Zn2+ or activated Ras expression stimulated the activity of a 950 bp Egr‐1 promoter‐reporter gene construct and this is abrogated in the presence of mutant Ras and Raf. The accumulated data show that Egr‐1 gene expression is regulated by multiple mechanisms, as would be needed for putative role in Cell proliferation, in suppression of transformation and in differentiation.
Localization of a “Feeding Center” in the Hypothalamus of the Rat

Development of obesity in animals following destructive lesions placed in or ventrolateral to the ventromedial nucleus of the hypothalamus is a well-established fact( 1 , 2 , 3 , 4 , 5 , 6 ). This obesity has been shown to arise primarily from a marked increase in food intake, or from what has been termed “hyperphagia. ” In an experimental investigation being carried out to discover the effect on food intake, etc. of small electrolytic lesions placed by the Horsley-Clarke instrument in other areas of the hypothalamus of the albino rat, a well-localized area has been found in the lateral hypothalamus, bilateral destruction of which is followed by a complete absence of eating. This area is situated in the extreme lateral portion of the lateral hypothalamus at the same rostro-caudal level (coordinate) as the ventromedial nucleus (Fig. 1). Small, bilateral, electrolytic lesions produced in this area by a current of 1 milliampere used for 15 sec, completely inhibit food intake to the point where the rat dies of starvation. On the other hand, after a unilateral lesion in this area, the animal goes on eating normally; when another unilateral lesion is made in the corresponding area of the opposite side, however, the animal then ceases to eat. This area is so well circumscribed that if the destructive lesion is placed even 0.5 to 1 mm away from it in any direction, this complete absence of eating does not develop. Bilateral lesions made in adjacent areas may result in either decreased eating or failure to eat for the first few days after the operation, but such animals resume eating within a short period.
QAT2 - the QCRI advanced transcription and translation system

Abstract QAT 2 is a multimedia content translation web service devel-oped by QCRI to help content provider to reach audiences andviewers speaking different languages. It is built with estab-lishing open source technologies such as KALDI, Moses andMaryTTS, to provide a complete translation experience for webusers. It translates text content in its original format, and pro-duce translated videos with speech-to-speech translation. Theresult is a complete native language experience for end userson foreign language websites. The system currently supportstranslation from Arabic to English.Index Terms: speech recognition, speech-to-speech transla-tion, machine translation, text-to-speech synthesis 1. Introduction Every day, new online multimedia content is generated acrossthe globe. Unfortunately, language barriers pose a limitationfor the dissemination of such content. In recent years, languagetechnologies have made important progress, and have becomeviable tools that enable users to consume this information. On-line translators (e.g. Google Translate, Bing Translate) are goodexamples of how translation technologies can help reduce thelanguage gap. However, most of the current technology is onlyfocused on text, and it is not prepared to deal with the growingtrend of multimedia content. For instance, many news articlesand blog posts come accompanied by complementary videos.QCRI has developed the QAT
Dietary flavonoids enhance conspicuousness of a melanin‐based trait in male blackcaps but not of the female homologous trait or of sexually monochromatic traits

Signalling theory predicts that signals should fulfil three fundamental requirements: high detectability, discriminability and, most importantly, reliability. Melanins are the most common pigments in animals. Correlations between genotypic and phenotypic qualities of the sender and size and morph of melanin‐based traits are known, but it is contentious whether melanin‐based colouration may signal any quality. We examined the effect of supplementing blackcaps (Sylvia atricapilla) with flavonoids, potent plant antioxidants, on plumage colouration. We demonstrate that melanin‐based colour can fulfil all requirements of signals of phenotypic condition. As predicted by sexual selection theory, flavonoid supplementation influenced only the sexually dichromatic black cap of males, whereas the female homologous trait and the sexually monochromatic back colouration remained unaffected. Using avian vision models we show that birds can estimate male flavonoid intake from colouration of males’ black cap. Because flavonoid ingestion can increase immune responsiveness in blackcaps, melanin head colouration may signal environmentally determined immune condition.
Evaluating the impact of point-of-care diagnostics on disease outbreaks in low resource settings

Rapid disease diagnosis is critical during infectious disease outbreaks to enable early intervention measures and minimize risk of disease transmission. Recent outbreaks in lowresource settings have highlighted challenges with traditional laboratory-based diagnostic approaches including a dependence on supporting infrastructure and highly trained users. Limitations of laboratory-based devices often result in geographical separation of labs from cases creating delays and barriers for diagnosis. There is increasing interest in the use of point-of-care diagnostics during outbreaks to enable more dispersed field diagnostic approaches and improve accessibility of testing. Point-of-care diagnostics, however, are often less accurate than laboratory-based tests, which can make them a less trusted option. This thesis explores the possibility that accessible, less accurate point-of-care devices could enable more efficient containment of disease outbreaks compared to current practices that employ expensive, and often distant laboratory-based tests. Although the benefit of point-of-care devices has been discussed anecdotally, little work has been done to quantify the relative impact of point-of-care diagnostics on transmission characteristics during an outbreak. This thesis aims to establish a basic cross-domain simulation model that considers medical, engineering, and societal/cultural factors that contribute to disease outbreak outcomes. The simulation approach is used to assess the trade-off between diagnostic access and accuracy during the 2014 West Africa Ebola outbreak to determine if point-of-care devices could have offered a benefit. A sensitivity analysis is also conducted to assess the potential impact of diagnostics on future outbreaks. Simulation results support the hypothesis that deployment of point-of-care devices to increase accessibility of testing could significantly reduce the number of secondary infections during an outbreak. This finding is shown to be true across outbreaks of varying sizes and transmission characteristics and for devices with varying accuracy performance. Thesis Supervisor: Richard Charles Larson Title: Mitsui Professor
Metaheuristic Solutions for Solving Controller Placement Problem in SDN-based WAN Architecture

Software Defined Networks (SDN) is a popular paradigm in the modern networking systems that decouples the control logic from the underlying hardware devices. The control logic has implemented as a software component and residing in a server called controller. To increase the performance, deploying multiple controllers in a largescale network is one of the key challenges of SDN. To solve this, authors have considered controller placement problem (CPP) as a multi-objective combinatorial optimization problem and used different heuristics. Such heuristics can be executed within a specific time-frame for small and medium sized topology, but out of scope for large scale instances like Wide Area Network (WAN). In order to obtain better results, we propose Particle Swarm Optimization (PSO) and Firefly two population-based meta-heuristic algorithms for optimal placement of the controllers, which take a particular set of objective functions and return the best possible position out of them. The problem has been defined, taking into consideration both controllers to switch and inter-controller latency as the objective functions. The performance of the algorithms evaluated on a set of publicly available network topologies in terms execution time. The results show that the FireFly algorithm performs better than PSO and random approach under various conditions.
SEE in a 0.15 /spl mu/m fully depleted CMOS/SOI commercial Process

We evaluated single-event effects (SEEs) in test circuits fabricated at OKI with their 0.15 /spl mu/m Fully Depleted CMOS/SOI commercial process. The sample devices were designed with hardness-by design (HBD) methodology. The results are discussed for an effective hardening design associated with SEEs.
A Structured Loop Modulates Coupling between the Substrate-binding and Dimerization Domains in the Multidrug Resistance Transporter EmrE*

Background: EmrE is a multidrug transporter. Results: NMR spectroscopy was used to reveal a structured loop adjoining the substrate-binding and dimerization domains. Conclusion: The linker structure and composition are conserved across the small multidrug resistance family and necessary for ion-coupled transport. Significance: Loops in secondary active transporters can play an active role in efflux pump function and require characterization in lipid bilayers. Secondary active transporters undergo large conformational changes to facilitate the efflux of substrates across the lipid bilayer. Among the smallest known transport proteins are members of the small multidrug resistance (SMR) family that are composed of four transmembrane (TM) domains and assemble into dimers. An unanswered question in the SMR field is how the dimerization domain (TM4) is coupled with the substrate-binding chamber (TM1–3). To provide insight for this essential aspect of ion-coupled transport, we carried out a structure-function study on the SMR protein EmrE using solid-state NMR spectroscopy in lipid bilayers and resistance assays in Escherichia coli. The chemical shifts for EmrE were consistent with β-strand secondary structure for the loop connecting TM3 and TM4. Based on these structural results, EmrE mutants were created to ascertain whether a specific loop length and composition were necessary for function. A linker encompassing six extra Gly residues relative to wild-type EmrE failed to give resistance; however, the number of residues in the loop was not the only criterion for a functional efflux pump. Replacement of the central hydrophobic residue with Gly (L83G) also conferred no ethidium resistance phenotype, which supported the conclusion that the structure and length of the loop were both essential for ion-coupled transport. Taken together with a bioinformatics analysis, a structured linker is likely conserved across the SMR family to play an active role in mediating the conformational switch between inward-open and outward-open states necessary for drug efflux. These findings underscore the important role loops can play in mediating efflux.
INTELiCON: Intelligent Connectivity Framework for the Simultaneous Use of Multiple Interfaces

Widespread deployment of Wi-Fi together with 3G upgrades to cellular networks is rapidly creating areas where multiple wireless IP technologies are accessible. WiMAX will further contribute to this phenomenon. The ability to use diverse access technologies simultaneously creates opportunities to improve application service quality and reliability. In this paper, we present an intelligent connectivity framework (INTELiCON) that allows devices to exploit access diversity in new ways. INTELiCON provides a modular, flexible platform for discovering, selecting, executing and evaluating the most appropriate connectivity strategies. The framework executes connectivity strategies and evaluates their effectiveness while maintaining transparency to the application layer. Furthermore INTELiCON can also dynamically implement new strategies to meet variations in network conditions or application requirements. We present the architectural characteristics of the INTELiCON framework with details of a prototype implementation and show how the framework exploits access diversity to support high-quality streaming video despite limited resources and unreliable links.
Molecular epidemiology of influenza B virus among hospitalized pediatric patients in Northern Italy during the 2015-16 season

Background The influenza B viruses belong to two lineages distinguished by their genetic and antigenic characteristics, which are referred to as the Yamagata and Victoria lineages, designated after their original isolates, B/Yamagata/16/88 and B/Victoria/2/87. The primary aim of this study was to evaluate the molecular characteristics of influenza B viruses circulating in a region of Northern Italy, Lombardia, during the influenza season of 2015–2016. Methods Influenza B virus was detected using a respiratory virus panel of assays and an influenza B-specific real-time polymerase chain reaction. The complete influenza B hemagglutinin (HA) gene was amplified and sequenced directly from clinical specimens. Phylogenetic analysis was performed using nucleotide sequences. Results A total of 71 hospitalized pediatric patients were influenza B positive. Phylogenetic analysis showed that the great majority of influenza B strains (66/71, 93.0%) belonged to the Victoria-lineage and were antigenically like vaccine strain (B/Brisbane/60/2008) included only in the quadrivalent vaccine. In the detected influenza B strains, a series of amino acid changes were observed in the antigenic regions: I117V, V124A, N129D, V146I, N197D, T199A, and A202T. However, only 2 amino acid changes were observed in the HA regions involved in receptor binding or in antibody recognition. Conclusions All the influenza B strains identified in this study belonged to the influenza B Victoria lineage not included in the trivalent vaccine commonly used by the general population during the 2015–2016 influenza season in Italy. This indicates that protection against influenza B infection in the vaccinated population was in general very poor during the 2015–2016 influenza season.
¿Convergen las diferentes disciplinas de conocimiento? evidencia cuantitativa

Traditional epistemological models classify knowledge into separate disciplines with different objects of study and specific techniques, with some frameworks even proposing hierarchies (such as Comte’s). According to thinkers such as John Holland or Teilhard de Chardin, the advancement of science involves the convergence of disciplines. This proposed convergence can be studied in a number of ways, such as how works impact research outside a specific area (citation networks) or how authors collaborate with other researchers in different fields (collaboration networks). While these studies are delivering significant new insights, they cannot easily show the convergence of different topics within a body of knowledge. This paper attempts to address this question in a quantitative manner, searching for evidence that supports the idea of convergence in the content of the sciences themselves (that is, whether the sciences are dealing with increasingly the same topics). We use Latent Dirichlet Analysis (LDA), a technique that is able to analyze texts and estimate the relative contributions of the topics that were used to generate them. We apply this tool to the corpus of the Santa Fe Institute (SFI) working papers, which spans research on Complexity Science from 1989 to 2015. We then analyze the relatedness of the different research areas, the rise and demise of these sub-disciplines over time and, more broadly, the convergence of the research body as a whole. Combining the topic structure obtained from the collected publication history of the SFI community with techniques to infer hierarchy and clustering, we reconstruct a picture of a dynamic community which experiences trends, periodically recurring topics, and shifts in the closeness of scholarship over time. We find that there is support for convergence, and that the application of quantitative methods such as LDA to the study of knowledge can provide valuable insights that can help researchers navigate the increasingly wide literature as well as identifying potentially fruitful areas for research collaboration.