Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of an Acrylic Polymer Blend on the Physical Stability of Film-Coated Theophylline Pellets

The purpose of this study was to investigate the physical stability of a coating system consisting of a blend of two sustained release acrylic polymers and its influence on the drug release rate of theophylline from coated pellets. The properties of both free films and theophylline pellets coated with the polymer blend were investigated, and the miscibility was determined via differential scanning calorimetry. Eudragit® RS 30 D was plasticized by the addition of Eudragit® NE 30 D, and the predicted glass transition temperature (Tg) of the blend was similar to the experimental values. Sprayed films composed of a blend of Eudragit® NE 30 D/Eudragit® RS 30 D (1:1) showed a water vapor permeability six times greater than films containing only Eudragit® NE 30 D. The presence of quaternary ammonium functional groups from the RS 30 D polymer increased the swellability of the films. The films prepared from the blend exhibited stable permeability values when stored for 1 month at both 25°C and 40°C, while the films which were composed of only Eudragit® NE 30 D showed a statistically significant decrease in this parameter when stored under the same conditions. Eudragit® NE 30 D/Eudragit® RS 30 D (1:1)-sprayed films decreased in elongation from 180% to 40% after storage at 40°C for 1 month, while those stored at 25°C showed no change in elongation. In coated pellets, the addition of Eudragit® RS 30 D to the Eudragit® NE 30 D increased the theophylline release rate, and the pellets were stable when stored at 25°C for a period of up to 3 months due to maintenance of the physico-mechanical properties of the film. Pellets stored at 40°C exhibited a decrease in drug release rate over time as a result of changes in film physico-mechanical properties which were attributed to further coalescence and densification of the polymer. When the storage temperature was above the Tg of the composite, instabilities in both drug release rate and physical properties were evident. Stabilization in drug release rate from coated pellets could be correlated with the physico-mechanical stability of the film formulation when stored at temperatures below the Tg of the polymer.
Multilevel Fresnel zone lenses capable of being fabricated with only one binary mask

Multi-level approximated Fresnel zone lenses with reduced level numbers in the outer zones are investigated and compared with Fresnel zone lenses of unique level numbers over the whole lens. Calculations of the fabrication error effects on diffraction efficiency for both lens types are performed. Measurements of focussing efficiency show that. especially for Gaussian beam illumination, segmented Fresnel zone lenses can reach nearly as high focussing efficiencies as normal Fresnel zone lenses. Arrays of segmented lenses can be fabricated using only one binary Fresnel zone lens mask with the aid of a modified optical stepper with fixed scaling down factors in the ratio of 1: 1/(root)2 from one to the next step of pattern transfer in the lithographic process. The fabrication of such lenses could be advantageous because the generation of precise e-beam written masks with a large number of binary ring zones is time consuming and expensive.
Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis

Cited2 is a transcriptional modulator with pivotal roles in different biological processes. Cited2-deficient mouse embryos manifested two major defects in the developing eye. An abnormal corneal-lenticular stalk was characteristic of Cited2-/- developing eyes, a feature reminiscent of Peters' anomaly, which can be rescued by increased Pax6 gene dosage in Cited2-/- embryonic eyes. In addition, the hyaloid vascular system showed hyaloid hypercellularity consisting of aberrant vasculature, which might be correlated with increased VEGF expression in the lens. Deletion of Hif1a (which encodes HIF-1α) in Cited2-/- lens specifically eliminated the excessive accumulation of cellular mass and aberrant vasculature in the developing vitreous without affecting the corneal-lenticular stalk phenotype. These in vivo data demonstrate for the first time dual functions for Cited2: one upstream of, or together with, Pax6 in lens morphogenesis; and another in the normal formation of the hyaloid vasculature through its negative modulation of HIF-1 signaling. Taken together, our study provides novel mechanistic revelation for lens morphogenesis and hyaloid vasculature formation and hence might offer new insights into the etiology of Peters' anomaly and ocular hypervascularity.
Spectral reflectance modeling of ZnO layers made with Atomic Layer Deposition for application in optical fiber Fabry-Perot interferometric sensors

Suitability of zinc oxide (ZnO) layers grown using Atomic Layer Deposition for operation in optical-fiber extrinsic Fabry-Perot sensors is investigated using a numerical model. Reflectance spectra obtained using the developed model indicate that the application of these layers in optical-fiber extrinsic Fabry-Perot sensors is difficult as it may require a source whose spectrum width is about 300 nm. A series of ZnO layers grown on end faces of SMF-28 fiber were prepared and their reflectance spectra were recorded by an optical spectrum analyser in order to verify the modelling results. The spectra contain a series of peaks not predicted by the model, which is attributed to two-mode propagation in the SMF-28 fiber connecting the ZnO layer with the rest of the measurement system.
Knowledge Tags Maintenance in Heterogeneous Web Content : The Repository

Knowledge tags provide new layer of a lightweight semantics over the Web content, in which computer systems and the Web users share their knowledge about tagged content. To allow this type of collaboration, tags’ data must be stored in form which is understandable for computer systems and provides flexible and fast access for these systems. The next issue is dynamic character of the Web, whose content changes in time. These changes can invalidate knowledge tags, their parts or anchoring in tagged content. In this paper we present basic ideas of automatized knowledge tags maintenance and our approach for knowledge tags repository.
Relaxor-based ferroelectric single crystals for electromechanical actuators

The piezoelectric properties of relaxor based ferroelectric single crystals, such as Pb(Zn1/3Nb2/3)O3 - PbTiO3 (PZN-PT) and Pb(Mg1/3Nb2/3)O3 - PbTiO3 (PMN- PT) were investigated for electromechanical actuators. In contrast to polycrystalline materials such as Pb(Zr,Ti)O3 (PZT's), morphotropic phase boundary compositions were not essential for high piezoelectric strain. Piezoelectric coefficients (d33's) > 2500 pC/N and subsequent strain levels up to > 0.6% with minimal hysteresis were observed. Crystallographically, high strains are achieved for <001> oriented rhombohedral crystals, though <111> is the polar direction. Ultrahigh strain levels up to 1.7%, an order of magnitude larger than those available from conventional piezoelectric and electrostrictive ceramics could be achieved, being related to an E-field induced phase transformation. Strain vs. E-field behavior under external stress was also much superior to that of conventional piezoelectric ceramics. High electromechanical coupling (k33) > 90% and low dielectric loss <1%, along with large strain make these crystals promising candidates for high performance solid state actuators.
Synchronization of Geo Spaceborne-Airborne Bistatic SAR

This paper analyzes the synchronization of a bistatic synthetic aperture radar (SAR) system based upon a geostationary transmitter and small "receive-only" SAR systems mounted on airplanes or unmanned aerial vehicles (UAVs), namely GEO Spaceborne-Airborne Bistatic SAR. This paper will analyze and present our solution of the space synchronization, time synchronization, frequency synchronization and phase synchronization for the GEO Spaceborne-Airborne bistatic SAR respectively. It will first introduce the GEO Spaceborne-Airborne bistatic SAR system and geometry model briefly. Then possible solutions of the system synchronization will be discussed. It will introduce the synchronization scheme based on the direct path between the transmitter and receiver. It uses synchronization modules to realize the time and frequency synchronization. A mathematical model considering the time and frequency synchronization error is given and a phase error analysis is performed. Range and azimuth compressions of a single target are implemented by simulations.
Mapping Freshwater Ecological Systems with Nested Watersheds in South America

In 2006, TNC sought to develop a classification of watershed units to be used in conservation planning and conservation measures benchmarks in South America. The South America Conservation Region initiated this process by hiring a team leader and appointing time of its GIS staff to the project. The objectives of this project are to: Map freshwater ecological systems at a continental scale for priority setting and conservation strategy planning Build freshwater-related datasets for reference and to have a standardized dataset to perform analysis Perform parallel analyses related to threats assessments, protected area gap analyses and other applications The process that we followed aimed to replicate the classification methodology proposed by Higgins et al, 2005 (Figure 1). Using this hierarchical classification system, large
[History of hysteria].

The best ebooks about A History Of Hysteria that you can get for free here by download this A History Of Hysteria and save to your desktop. This ebooks is under topic such as history and hysteria: writing the body in portrait of dora a history of hysteria myoval women and hysteria in the history of mental health a history of hysteria nusing history hysteria: historical resources in the city of san a history of hysteria biscit a history of hysteria tvdots a history of hysteria mobtec environmental alarmism in context underground notes hunter, dianne Ã¢Â€Âœhysteria, psychoanalysis, and jstor passions of the voice: hysteria, narrative, and the figure the history of hysteria as a medical concept basic course history/hysteria caledon institute of social policy colette soler history and hysteria: the witty butcher's wife* observations on the natural history of hysteria from female sexuality and hysteria to feminine psychology hysteria: a history in two stages 1 researchgate hysteria the disturbing history lvown hysteria the disturbing history acph evaluation of syncope in children history, not hysteria: a main street history and hysteria home main site hysteria the disturbing history lmskan hysteria the disturbing history qawise hysterectomy throughout history doiserbia hysteria linkspringer on the 'disappearance' of hysteria: a study in the the hysterical character american college of orgonomy hysteria sony pictures classics sonyclassics hysteria binghamton university history of physical and Ã¢Â€Â ̃moralÃ¢Â€ÂTM treatment of hysteria a history of hysteria pcooke female hysteria across cultures and periods in american hysteria the disturbing history svezia hysteria the disturbing history cogenv hysteria the disturbing history albary hysteria and neurasthenia in pre-1914 british medical used to treat it hysteria and mechanical man chsbs the confederate flag: history -vhysteria by steve quick conjuring history: the many interpretations of the salem hysteria the disturbing history djtnet hysteria the disturbing history bgpltd hysteria the disturbing history brucol elaine showalter: hysteriaÃ¢Â€ÂTMs historian w the lancet
Dietary Patterns and Pancreatic Cancer Risk: A Meta-Analysis

A number of studies have examined the associations between dietary patterns and pancreatic cancer risk, but the findings have been inconclusive. Herein, we conducted this meta-analysis to assess the associations between dietary patterns and the risk of pancreatic cancer. MEDLINE (provided by the National Library of Medicine) and EBSCO (Elton B. Stephens Company) databases were searched for relevant articles published up to May 2016 that identified common dietary patterns. Thirty-two studies met the inclusion criteria and were finally included in this meta-analysis. A reduced risk of pancreatic cancer was shown for the highest compared with the lowest categories of healthy patterns (odds ratio, OR = 0.86; 95% confidence interval, CI: 0.77–0.95; p = 0.004) and light–moderate drinking patterns (OR = 0.90; 95% CI: 0.83–0.98; p = 0.02). There was evidence of an increased risk for pancreatic cancer in the highest compared with the lowest categories of western-type pattern (OR = 1.24; 95% CI: 1.06–1.45; p = 0.008) and heavy drinking pattern (OR = 1.29; 95% CI: 1.10–1.48; p = 0.002). The results of this meta-analysis demonstrate that healthy and light–moderate drinking patterns may decrease the risk of pancreatic cancer, whereas western-type and heavy drinking patterns may increase the risk of pancreatic cancer. Additional prospective studies are needed to confirm these findings.
ReStore: reusing results of MapReduce jobs in pig

Analyzing large scale data has become an important activity for many organizations, and is now facilitated by the MapReduce programming and execution model and its implementations, most notably Hadoop. Query languages such as Pig Latin, Hive, and Jaql make it simpler for users to express complex analysis tasks, and the compilers of these languages translate these complex tasks into workflows of MapReduce jobs. Each job in these workflows reads its input from the distributed file system used by the MapReduce system (e.g., HDFS in the case of Hadoop) and produces output that is stored in this distributed file system. This output is then read as input by the next job in the workflow. The current practice is to delete these intermediate results from the distributed file system at the end of executing the workflow. It would be more useful if these intermediate results can be stored and reused in future workflows. We demonstrate ReStore, an extension to Pig that enables it to manage storage and reuse of intermediate results of the MapReduce workflows executed in the Pig data analysis system. ReStore matches input workflows of MapReduce jobs with previously executed jobs and rewrites these workflows to reuse the stored results of the matched jobs. ReStore also creates additional reuse opportunities by materializing and reserving the output of query execution operators that are executed within a MapReduce job. In this demonstration we showcase the MapReduce jobs and sub-jobs recommended by ReStore for a given Pig query, the rewriting of input queries to reuse stored intermediate results, and a what-if analysis of the effectiveness of reusing stored outputs of previously executed jobs.
A Critique of Pure Hierarchy: Uncovering Cross-Cutting Structure in a Natural Dataset

How best can we understand – and visualize – the structure in multi-dimensional data? One common approach is to rely on hierarchical cluster analysis, either for theoretical or for more descriptive reasons. Here, we point out that an apparently revealing hierarchical clustering solution may well be compatible with structure that is not well characterized as a hierarchy. In particular, a hierarchical description can be equally consistent with crosscutting rather than strictly hierarchical, or nested, structure. We offer an alternative approach, based on inspection of the feature vectors provided by a singular value decomposition (SVD) which allows a flexible mixture of hierarchical and cross-cutting dimensions and which can reveal whether dimensions are cross-cutting or nested. The SVD offers a more flexible representation than a hierarchy in that it can capture either hierarchical or cross-cutting structure or blends of these two structure types, or, indeed, many other structure types. We then introduce a refinement of the SVD approach based on sparse principal component analysis that leads to more easily interpretable dimensions. In our dataset, these dimensions correspond to aquatic vs. land animals, large vs. small animals, predators vs prey animals, and primates vs. other mammals.
Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes

The drug-drug interaction (DDI) potential of deleobuvir, an hepatitis C virus (HCV) polymerase inhibitor, and its two major metabolites, CD 6168 (formed via reduction by gut bacteria) and deleobuvir-acyl glucuronide (AG), was assessed in vitro. Area-under-the-curve (AUC) ratios (AUCi/AUC) were predicted using a static model and compared with actual AUC ratios for probe substrates in a P450 cocktail of caffeine (CYP1A2), tolbutamide (CYP2C9), and midazolam (CYP3A4), administered before and after 8 days of deleobuvir administration to HCV-infected patients. In vitro studies assessed inhibition, inactivation and induction of P450s. Induction was assessed in a short-incubation (10 hours) hepatocyte assay, validated using positive controls, to circumvent cytotoxicity seen with deleobuvir and its metabolites. Overall, P450 isoforms were differentially affected by deleobuvir and its two metabolites. Of note was more potent CYP2C8 inactivation by deleobuvir-AG than deleobuvir and P450 induction by CD 6168 but not by deleobuvir. The predicted net AUC ratios for probe substrates were 2.92 (CYP1A2), 0.45 (CYP2C9), and 0.97 (CYP3A4) compared with clinically observed ratios of 1.64 (CYP1A2), 0.86 (CYP2C9), and 1.23 (CYP3A4). Predictions of DDI using deleobuvir alone would have significantly over-predicted the DDI potential for CYP3A4 inhibition (AUC ratio of 6.15). Including metabolite data brought the predicted net effect close to the observed DDI. However, the static model over-predicted the induction of CYP2C9 and inhibition/inactivation of CYP1A2. This multiple-perpetrator DDI scenario highlights the application of the static model for predicting complex DDI for CYP3A4 and exemplifies the importance of including key metabolites in an overall DDI assessment.
Shrinkage analysis of reinforced concrete floors using shrinkage-adjusted elasticity modulus

The shrinkage of large reinforced concrete floors often gives rise to cracking problems. To identify the problematic areas, shrinkage movement analysis is often carried out by finite element method with proper creep and shrinkage models using step-by-step time integration. However as the full stress history prior to the time interval considered is necessary, with the increase in the number of time intervals used, the amount of computations increases dramatically. Therefore a new method using the shrinkage-adjusted elasticity modulus (SAEM) is introduced so that analysis can be carried out using one single step. Examples are presented to demonstrate its usefulness.
Modelling and Rendering Graphics Scenes Composed of Multiple Volumetric Datasets

This paper presents a method for modelling graphics scenes consisting of multiple volumetric objects. A two‐level hierarchical representation is employed, which enables the reduction of the overall storage consumption as well as rendering time. With this approach, different objects can be derived from the same volumetric dataset, and 2D images can be trivially integrated into a scene. The paper also describes an efficient algorithm for rendering such scenes on ordinary workstations, and addresses issues concerning memory requirements and disk swapping.
Construction Mechanism of Reticular Structure of Plant Fiber

This paper investigated and validated the mechanisms and principles for constructing reticular structure of plant fiber through frothing solution approach. After process, plant fibers became low-density reticular-structured block with all properties meeting Chinese standards for cushion packing materials. The bonds between fibers acted as knots in a truss and were strong enough to keep space occupied by bubbles in the frothing solution from shrinking in the subsequent draining process. The formation of the reticular structure depends mainly on the pressure difference between inside and outside bubble, the effect of surface adsorbent force on bubble film, and hydrogen bond among fiber hydroxide.
A shapelet transform for time series classification

The problem of time series classification (TSC), where we consider any real-valued ordered data a time series, presents a specific machine learning challenge as the ordering of variables is often crucial in finding the best discriminating features. One of the most promising recent approaches is to find shapelets within a data set. A shapelet is a time series subsequence that is identified as being representative of class membership. The original research in this field embedded the procedure of finding shapelets within a decision tree. We propose disconnecting the process of finding shapelets from the classification algorithm by proposing a shapelet transformation. We describe a means of extracting the k best shapelets from a data set in a single pass, and then use these shapelets to transform data by calculating the distances from a series to each shapelet. We demonstrate that transformation into this new data space can improve classification accuracy, whilst retaining the explanatory power provided by shapelets.
Expression Profiling of Huntington's Disease Models Suggests That Brain-Derived Neurotrophic Factor Depletion Plays a Major Role in Striatal Degeneration

Many pathways have been proposed as contributing to Huntington's disease (HD) pathogenesis, but generally the in vivo effects of their perturbation have not been compared with reference data from human patients. Here we examine how accurately mechanistically motivated and genetic HD models recapitulate the striatal gene expression phenotype of human HD. The representative genetic model was the R6/2 transgenic mouse, which expresses a fragment of the huntingtin protein containing a long CAG repeat. Pathogenic mechanisms examined include mitochondrial dysfunction; profiled in 3-nitropropionic acid-treated rats, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice, and PGC-1α knock-out mice; and depletion of brain-derived neurotrophic factor (BDNF) using heterozygous and forebrain-specific BDNF-knock-out mice (BDNF HET , Emx-BDNF KO ). Based on striatal gene expression, we find the BDNF models, both heterozygous and homozygous knock-outs, to be more like human HD than the other HD models. This implicates reduced trophic support as a major pathway contributing to striatal degeneration in HD. Because the majority of striatal BDNF is synthesized by cortical neurons, the data also imply that cortical dysfunction contributes to HD's hallmark effects on the basal ganglia. Finally, the results suggest that striatal lesions caused by mitochondrial toxins may arise via pathways different from those that drive neurodegeneration in HD. Based on these findings, we present a testable model of HD pathogenesis that, unlike most models, begins to account for regional specificity in human HD and the absence of such specificity in genetic mouse models of HD.