Miracle-dz/UniFAR-FTUs huggingface dataset:
Motor excitability is reduced prior to voluntary movements in children and adolescents with Tourette syndrome

Tourette syndrome (TS) is a neuro-developmental disorder characterized by the occurrence of motor and vocal tics: involuntary, repetitive, stereotyped behaviours that occur with a limited duration, often typically many times in a single day. Previous studies suggest that children and adolescents with TS may undergo compensatory, neuroplastic changes in brain structure and function that help them gain control over their tics. In the current study we used single-pulse and dual-site paired-pulse transcranial magnetic stimulation (TMS), in conjunction with a manual choice reaction time task that induces high levels of inter-manual conflict, to investigate this conjecture in a group of children and adolescents with TS, but without co-morbid Attention Deficit Hyperactivity Disorder (ADHD). We found that performance on the behavioural response-conflict task did not differ between the adolescents with TS and a group of age-matched typically developing individuals. By contrast, our study demonstrated that cortical excitability, as measured by TMS-induced motor-evoked potentials (MEPs), was significantly reduced in the TS group in the period immediately preceding a finger movement. This effect is interpreted as consistent with previous suggestions that the cortical hyper-excitability that may give rise to tics in TS is actively suppressed by cognitive control mechanisms. Finally, we found no reliable evidence for altered patterns of functional inter-hemispheric connectivity in TS. These results provide evidence for compensatory brain reorganization that may underlie the increased self-regulation mechanisms that have been hypothesized to bring about the control of tics during adolescence.
Mixed-Initiative Interfaces for Slide-Ware Authoring and Presentation

We present current work on the NextSlidePlease slide-ware presentation tool and discuss how mixed-initiative principles may support the complex tasks of combining multiple linear presentations into a network of related content. We discuss future directions in two areas: supporting the layout of complex sets of interconnected slides, and refining the time requirements and content importance in these networks.
2.4GHZ Class AB power Amplifier For Healthcare Application

The objective of this research was to design a 2.4 GHz class AB Power Amplifier, with 0.18 um SMIC CMOS technology by using Cadence software, for health care applications. The ultimate goal for such application is to minimize the trade-offs between performance and cost, and between performance and low power consumption design. The performance of the power amplifier meets the specification requirements of the desired.
Reference charts of sitting height, leg length and body proportions for Chinese children aged 0–18 years

Abstract Background: The reference charts of sitting height (SH), subischial leg length (LL) and the sitting height/leg length ratio (SH/LL) are useful tools in assessing body proportion for clinicians and researchers in related areas. However, reference charts of body proportions for Chinese children and adolescents are limited. Aim: To construct reference charts of SH, LL and SH/LL for Chinese children and adolescents. Subjects and methods: Stature and sitting height of 92 494 (46 240 boys and 46 254 girls) healthy Han nationality children, aged 0–18 years, were measured in two national large-scale cross-sectional surveys in 2005 in China. SH/LL was selected as the indicator of body proportion. References of SH, LL and SH/LL were constructed using the LMS method. Results: The reference charts demonstrated that SH and LL increased with age. Growth in SH slowed by the age of 17 years in boys and 15 years in girls. Similarly, growth in LL slowed at 16 years in boys and 14 years in girls. The SH/LL ratio declined from birth (2.00 in boys and 2.03 in girls) to 13 years in boys (1.11) and to 11 years in girls (1.13), then increased slightly to the age of 18 (1.16 in boys and 1.18 in girls). The gender difference of SH/LL was not significantly different before the age of 11 years. After the age of 11, SH/LL appeared elevated in girls compared to boys. Conclusions: The reference charts of SH, LL and SH/LL are useful tools for assessing body proportions for Chinese children and adolescent individuals.
Unifying Model-based and Reactive Programming within a Model-based Executive

Real-time model-based deduction has recently emerged as a vital component in Al’s tool box for developing highly autonomous reactive systems. Yet one of the current hurdles towards developing model-based reactive systems is the number of methods simultaneously employed, and their corresponding melange of programming and modeling languages. This paper offers an important step towards unification of reactive and model-based programming, providing the capability to monitor mixed hardware/software systems. We introduce RMPL, a rich modeling language that combines probabilistic, constraint-based modeling with reactive programming constructs, while offering a simple semantics in terms of hidden state Markov processes. We introduce probabilistic, hierarchical constraint automata, which allow Markov processes to be expressed in a compact representation that preserves the modularity of RMPL programs. Finally, a model-based executive, called RBurton is described that exploits this compact encoding to perform efficent simulation, belief state update and control sequence generation.
Incremental Discriminating Method for Acronyms in Heterogeneous Resources

In this paper, a method is proposed to discriminate acronyms and their full names or expansions in scientific and technical literature abstracts by learning Wikipedia definition statements. Through this study, we aim to verify the effective utilization of an open knowledge base in the knowledge processing of domain-specific fields. Experimental results confirm that a noun phrase (NP)-type feature has better performance than a noun (NN) type feature in terms of precision rate. On the contrary, the results of measuring query response rate indicate that a single NN-type feature has better performance than an NP-type feature. We also verify that additional collocation information can contribute to improve the response rate. This study is mainly divided into three parts: 1) a process of sense discrimination is classified into many steps according to feature types; 2) the measured results are combined and processed; and 3) a data fusion-based incremental approach is proposed for sense discrimination. Through the method, we can adjust a precision rate to a certain level while considering classifier response rate.
An error model for protein quantification

MOTIVATION Quantitative experimental data is the critical bottleneck in the modeling of dynamic cellular processes in systems biology. Here, we present statistical approaches improving reproducibility of protein quantification by immunoprecipitation and immunoblotting. RESULTS Based on a large data set with more than 3600 data points, we unravel that the main sources of biological variability and experimental noise are multiplicative and log-normally distributed. Therefore, we suggest a log-transformation of the data to obtain additive normally distributed noise. After this transformation, common statistical procedures can be applied to analyze the data. An error model is introduced to account for technical as well as biological variability. Elimination of these systematic errors decrease variability of measurements and allow for a more precise estimation of underlying dynamics of protein concentrations in cellular signaling. The proposed error model is relevant for simulation studies, parameter estimation and model selection, basic tools of systems biology. AVAILABILITY Matlab and R code is available from the authors on request. The data can be downloaded from our website www.fdm. uni-freiburg.de/~ckreutz/data.
Accurate Methods for the Statistics of Surprise and Coincidence

Much work has been done on the statistical analysis of text. In some cases reported in the literature, inappropriate statistical methods have been used, and statistical significance of results have not been addressed. In particular, asymptotic normality assumptions have often been used unjustifiably, leading to flawed results.This assumption of normal distribution limits the ability to analyze rare events. Unfortunately rare events do make up a large fraction of real text.However, more applicable methods based on likelihood ratio tests are available that yield good results with relatively small samples. These tests can be implemented efficiently, and have been used for the detection of composite terms and for the determination of domain-specific terms. In some cases, these measures perform much better than the methods previously used. In cases where traditional contingency table methods work well, the likelihood ratio tests described here are nearly identical.This paper describes the basis of a measure based on likelihood ratios that can be applied to the analysis of text.
SEAWAT Version 4: A Computer Program for Simulation of Multi-Species Solute and Heat Transport

The SEAWAT program is a coupled version of MODFLOW and MT3DMS designed to simulate three-dimensional, variable-density, saturated ground-water flow. Flexible equations were added to the program to allow fluid density to be calculated as a function of one or more MT3DMS species. Fluid density may also be calculated as a function of fluid pressure. The effect of fluid viscosity variations on ground-water flow was included as an option. Fluid viscosity can be calculated as a function of one or more MT3DMS species, and the program includes additional functions for representing the dependence on temperature. Although MT3DMS and SEAWAT are not explicitly designed to simulate heat transport, temperature can be simulated as one of the species by entering appropriate transport coefficients. For example, the process of heat conduction is mathematically analogous to Fickian diffusion. Heat conduction can be represented in SEAWAT by assigning a thermal diffusivity for the temperature species (instead of a molecular diffusion coefficient for a solute species). Heat exchange with the solid matrix can be treated in a similar manner by using the mathematically equivalent process of solute sorption. By combining flexible equations for fluid density and viscosity with multi-species transport, SEAWAT Version 4 represents variable-density ground-water flow coupled with multi-species solute and heat transport. SEAWAT Version 4 is based on MODFLOW-2000 and MT3DMS and retains all of the functionality of SEAWAT-2000. SEAWAT Version 4 also supports new simulation options for coupling flow and transport, and for representing constant-head boundaries. In previous versions of SEAWAT, the flow equation was solved for every transport timestep, regardless of whether or not there was a large change in fluid density. A new option was implemented in SEAWAT Version 4 that allows users to control how often the flow field is updated. New options were also implemented for representing constant-head boundaries with the Time-Variant Constant-Head (CHD) Package. These options allow for increased flexibility when using CHD flow boundaries with the zero-dispersive flux solute boundaries implemented by MT3DMS at constant-head cells. This
Scenario-Based Programming for Mobile Applications

We introduce a novel method for creating mobile applica-tions, integrating the Android SDK into PlayGo, a scenario-based behavioral programming framework. The method al-lows creating mobile applications simply by using a visualGUI editor, and then incrementally “playing in” scenariosthat construct the application’s behavior. This allows thedeveloper to focus on the behavior and interface rather thanon the syntax and code.
The origin of continental shelf and slope water in the New York Bight and Gulf of Maine: Evidence from H2 18O/H2 16O ratio measurements

The H218O/H216O ratio of meteoric water in eastern North America decreases with increasing latitude. The annual weighted average δ18O content of the Middle Atlantic Bight (MAB) and Gulf of Maine (GOM) rivers are −9.33‰ and −10.89‰, respectively. The δ18O compositions of the major east coast rivers are 2‰ enriched during summer months. By using H218O and salinity measurements, both conservative properties of sea water, the geographic origin of continental shelf water can be identified. The isotope-salinity tracer method, which has been used so successfully in polar regions, is also an effective method in the temperate MAB because subpolar waters are exported to this region. The apparent dilutent of slope water is −22‰ δ18O relative to standard mean ocean water. Water of this composition is presently forming in the Labrador Sea. Melt water from sea ice has nearly the same isotopic composition as the sea water from which it formed and thus may be distinguished from meteoric water. In March 1977, the New York Bight cold pool contained as much as 2.5% sea ice melt water. The Gulf of St. Lawrence is the nearest source of sea ice. The New York Bight ‘cold pool’ was renewed from the north between March and July, which was the extent of our sampling period.
Pulsating midmorning auroral arcs, filamentation of a mixing region in a flank boundary layer, and ULF waves observed during a Polar‐Svalbard conjunction

Magnetically conjugate observations by the HYDRA and the Magnetic Field Experiment instruments on Polar, meridian-scanning photometers and all-sky imagers at Ny-Alesund, and International Monitor for Auroral Geomagnetic Effects (IMAGE) magnetometers on November 30, 1997, illustrate aspects of magnetosphere-ionosphere coupling at 0900–1000 magnetic local times (MLT) and 70°–80° magnetic latitudes and their dependence on interplanetary parameters. Initially, Polar crossed a boundary layer on closed field lines where magnetospheric and magnetosheath plasmas are mixed. This region contains filaments where magnetospheric electron and ion fluxes are enhanced. These filaments are associated with field-aligned current structures embedded within the large-scale region 1 (R1) current. Ground auroral imagery document the presence at this time of discrete, east–west aligned arcs, which are in one-to-one correspondence with the filaments. Temporal variations present in these auroral arcs correlate with Pc 5 pulsations and are probably related to modulations in the interplanetary electric field. The auroral observations indicate that the filamented mixing region persisted for many tens of minutes, suggesting a spatial structuring. The data suggest further that the filamented, mixing region is an important source of the R1 current and the associated midmorning arcs. When the interplanetary magnetic field (IMF) turned strongly north, Polar had entered the dayside extension of the central plasma sheet/region 2 current system where it and the underlying ground magnetometers recorded a clear field line resonance of frequency ∼2.4 mHz (Pc 5 range). The source of these oscillations is most likely the Kelvin-Helmholtz instability. Subsequent to the IMF northward turning, the multiple arcs were replaced by a single auroral form to the north of Ny-Alesund (at 1000 MLT) in the vicinity of the westward edge of the cusp. ULF pulsation activity changed to the Pc 3–4 range in the regime of the pulsating diffuse aurora when the IMF went to an approximately Parker spiral orientation and the ground stations had rotated into the MLT sector of cusp emissions.
The Effect of a 12-Week Omega-3 Supplementation on Body Composition, Muscle Strength and Physical Performance in Elderly Individuals with Decreased Muscle Mass

The aim of the study was to assess the effect of a polyunsaturated omega-3 fatty acids (PUFA) supplementation on the parameters of body composition, muscle strength and physical performance in elderly people with decreased muscle mass (DMM). Fifty three elderly people with an ALM index (the ratio of appendicular lean mass to squared height) either below (−2SD: low muscle mass-LMM) or between (−1SD and −2SD: the risk of LMM-rLMM) the ALM index for the young Polish reference population were randomly assigned to PUFA-treated groups (LMM-PUFA, rLMM-PUFA) or control groups (LMM-control, rLMM-control). PUFA-treated groups received capsules containing 1.3 g of PUFA and 10 mg of vitamin E, while the control groups received 11 mg of vitamin E daily for 12 weeks. Body composition (BIA analysis), muscle strength (hand grip measured with dynamometer) and physical performance (Timed Up and Go test-TUG) were assessed before and after supplementation. No statistically significant differences were observed either in muscle mass or in the hand grip and TUG in any group. The post-pre difference (mean ± SD) in ALM index was as follows (kg/m2): LMM-PUFA: 0.00 ± 0.30, rLMM-PUFA: 0.00 ± 0.22, LMM-control: 0.03 ± 0.36, rLMM-control: –0.03 ± 0.20. In our study, a 12 week supplementation of PUFA did not affect the evaluated parameters in elderly individuals with DMM.
HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA

The microRNA (miRNA)-mediated repression of protein synthesis in mammalian cells is a reversible process. Target mRNAs with regulatory AU-rich elements (AREs) in their 3′-untranslated regions (3′-UTR) can be relieved of miRNA repression under cellular stress in a process involving the embryonic lethal and altered vision family ARE-binding protein HuR. The HuR-mediated derepression occurred even when AREs were positioned at a considerable distance from the miRNA sites raising questions about the mechanism of HuR action. Here, we show that the relief of miRNA-mediated repression involving HuR can be recapitulated in different in vitro systems in the absence of stress, indicating that HuR alone is sufficient to relieve the miRNA repression upon binding to RNA ARE. Using in vitro assays with purified miRISC and recombinant HuR and its mutants, we show that HuR, likely by its property to oligomerize along RNA, leads to the dissociation of miRISC from target RNA even when miRISC and HuR binding sites are positioned at a distance. Further, we demonstrate that HuR association with AREs can also inhibit miRNA-mediated deadenylation of mRNA in the Krebs-2 ascites extract, in a manner likewise depending on the potential of HuR to oligomerize.
Effects of anelasticity on reflection and transmission coefficients

It is known that the reflection and transmission coefficients used in the zeroth order approximation of asymptotic ray theory (ART) are identical to those obtained for the plane wave impinging on a plane interface separating two perfectly elastic half‐spaces. We have used ART to compute reflection and transmission coefficients for two viscoelastic media separated by a plane interface. Our method is different from the plane‐wave approach because the ART approach requires only a local application of the boundary conditions both for the eikonal and the ray amplitudes.
On the role of locality in learning stress patterns*

Abstract This paper presents a previously unnoticed universal property of stress patterns in the world's languages: they are, for small neighbourhoods, neighbourhood-distinct. Neighbourhood-distinctness is a locality condition defined in automata-theoretic terms. This universal is established by examining stress patterns contained in two typological studies. Strikingly, many logically possible – but unattested – patterns do not have this property. Not only does neighbourhood-distinctness unite the attested patterns in a non-trivial way, it also naturally provides an inductive principle allowing learners to generalise from limited data. A learning algorithm is presented which generalises by failing to distinguish same-neighbourhood environments perceived in the learner's linguistic input – hence learning neighbourhood-distinct patterns – as well as almost every stress pattern in the typology. In this way, this work lends support to the idea that properties of the learner can explain certain properties of the attested typology, an idea not straightforwardly available in optimality-theoretic and Principle and Parameter frameworks.
On naming H2 haplotypes: functional significance of MHC class Ib alleles.

George D. Snell began defining and naming the H2 haplotypes many years ago by histogenetic typing. Since then, a few haplotypes have been given an additional letter, such as bc for strain 129, to show that they are minor variants from the prototype (b). But by and large, differences in nonclassical class I antigens have been known (only? ) to those in the field without being acknowledged by a separate haplotype symbol. Thus, strains BALB/c and NZB/BlNJ are both considered H2d and strains C3H/HeJ and B10.BR are both called H2k, although each pair differs in the TL and Qa1 antigens. In parallel with the interest in nonclassical class I antigens, the need for an appropriate haplotype nomenclature is growing. The haplotypes that require splitting are b, d, k, q, and s; the symbol bc should be retained and used, and, for the other haplotypes, the suffix 2 denotes a Qa1a haplotype with highly TL-positive thymocytes.
Nectin and afadin: novel organizers of intercellular junctions

The cadherin superfamily plays key roles in intercellular adhesion. An emerging intercellular adhesion system, consisting of nectin and afadin, also has roles in organization of a variety of intercellular junctions either in cooperation with, or independently of, cadherin. Nectin is a Ca2+-independent immunoglobulin-like intercellular adhesion molecule, and afadin is a nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. This novel intercellular adhesion system has roles in the organization of E-cadherin-based adherens junctions and claudin-based tight junctions in epithelial cells. The adhesion system is furthermore involved in the formation of synapses in neurons and the organization of heterotypic junctions between Sertoli cells and spermatids in the testis.
An E1M--E2C fusion protein encoded by human papillomavirus type 11 is asequence-specific transcription repressor

We have isolated a putative, spliced E5 cDNA of human papillomavirus type 11 (HPV-11) by polymerase chain reaction amplification of cDNAs from an experimental condyloma. Using retrovirus-mediated gene transfer, we isolated two novel HPV-11 cDNAs, one of which had a splice linking nucleotides 1272 and 3377. This transcript also existed in experimental condylomata and in cervical carcinoma cells transfected with cloned genomic HPV-11 DNAs. The 5' end of the transcript in transfected cells originated upstream of the initiation codon of the E1 open reading frame (ORF). It could conceptually encode a fusion protein consisting of the amino-terminal 23% of the E1 ORF and the carboxy-terminal 40% of the E2 ORF. This E1M--E2C fusion protein contained both the DNA replication modulator domain E1M, as defined in the bovine papillomavirus system, and the DNA binding domain of the E2 protein, which regulates viral transcriptional activities. Indirect immunofluorescence with polyclonal antibodies raised against the bacterially expressed TrpE-HPV-11 E2 protein demonstrated nuclear localization of the E1M--E2C protein in cells transiently transfected with an expression plasmid. Immunoprecipitation revealed a specific protein with an apparent molecular weight of 42,000 in transfected cells. The chloramphenicol acetyltransferase assay established that the putative E1M--E2C protein was a potent transcriptional repressor of both E2-dependent and E2-independent HPV-11 enhancer/promoter activities. Northern (RNA) blot hybridization indicated the repression was on the transcriptional level. Mutational analysis suggested that the E1M--E2C protein is an E2-binding site-specific repressor. The fusion protein also repressed bovine papillomavirus type 1 (BPV-1) E2 protein-dependent BPV-1 enhancer activity. When constitutively expressed in mouse C127 cells, the E1M--E2C protein inhibited BPV-1 transformation and episomal DNA replication, consistent with a role in the modulation of replication.