Miracle-dz/UniFAR-FTUs huggingface dataset:
Understanding diseases by mouse click: the promise and potential of computational approaches in Systems Biology

Computational modelling approaches can nowadays build large‐scale simulations of cellular behaviour based on data describing detailed molecular level interactions, thus performing the space‐ and time‐scale integrations that would be impossible just by intuition. Recent progress in the development of both experimental methods and computational tools has provided the means to generate the necessary quantitative data and has made computational methods accessible even to non‐theorists, thereby removing a major hurdle that has in the past made many experimentalists hesitate to invest serious effort in formulating quantitative models. We describe how computational biology differs from classical bioinformatics, how it emerged from mathematical biology and elucidate the role it plays for the integration of traditionally separated areas of biomedical research within the larger framework of Systems Biology.
Sparsely-Packetized Predictive Control by Orthogonal Matching Pursuit

We study packetized predictive control, known to be robust against packet dropouts in networked systems. To obtain sparse packets for rate-limited networks, we design control packets via an L0 optimization, which can be effectively solved by orthogonal matching pursuit. Our formulation ensures asymptotic stability of the control loop in the presence of bounded packet dropouts.
Prediction of intracranial injury in children aged five years and older with loss of consciousness after minor head injury due to nontrivial mechanisms.

STUDY OBJECTIVE Indications for computed tomography (CT) in children with minor head injury remain controversial. The objective of this preliminary study is to determine whether a clinical decision rule developed for adults could be used in children aged 5 years and older. METHODS A prospective questionnaire was completed on all patients who were aged 5 to 17 years with major mechanisms of injury resulting in minor head injury (defined as normal Glasgow Coma Scale or modified coma scale in infants, plus normal brief neurologic examination) and loss of consciousness. The questionnaire documented 6 clinical variables: headache, emesis, intoxication, seizure, short-term memory deficits, and physical evidence of trauma above the clavicles. CT was obtained for all patients, findings were compared with the results of the questionnaires, and the sensitivity and specificity of the decision rule were determined. RESULTS Throughout a 30-month period, 175 patients were enrolled, with a mean age of 12.8 years. Fourteen (8%) patients had intracranial injury or depressed skull fracture on CT. The presence of any of the 6 criteria was significantly associated with an abnormal CT scan result (P<.05) and was 100% (95% confidence interval 73% to 100%) sensitive for identifying patients with intracranial injury. CONCLUSION In this preliminary study, CT use in pediatric patients with minor head injury could have been safely reduced by 23% by using a clinical decision rule previously validated in adults.
Search for infective mammalian type‐C virus‐related genes in the dna of human sarcomas and leukemias

DNA was extracted from two human sarcoma cell lines, TE‐32 and TE‐418, and the leukemic cells from five children with acute myelocytic leukemia, three children with acute lymphocytic leukemia and four adults with acute myelocytic leukemia. The DNAs, assayed for infectivity by transfection techniques, induced no measurable virus by methods which would detect known mammalian C‐type antigens or RNA‐directed DNA polymerase in TE‐32, D‐17 dog cells and other indicator cells, nor did they recombine with or rescue endogenous human or exogenous murine or baboon type‐C virus. Model systems used as controls were human sarcoma cells, TE‐32 and HT‐1080, and human lymphoma cells, TE‐543, experimentally infected with KiMuLV, GaLV or baboon type‐C virus, all of which released infectious virus and whose DNAs were infectious for TE‐32 and D‐17 dog cells. Other model systems included. two baboon placentas and one embryonic cell strain spontaneously releasing infectious endogenous baboon virus and yielding DNAs infectious for D‐17 dog cells but not for TE‐32 cells. Four other baboon embryonic tissues and two embryonic cell strains, releasing either low levels of virus or no virus, did not yield infectious DNA.
Outcomes and Costs of Patients Admitted to the Intensive Care Unit Due to Accidental or Intentional Poisoning

Introduction: Acute poisoning represents a major cause of morbidity and mortality, and many of these patients are admitted to the intensive care unit (ICU). However, little is known regarding ICU costs of acute poisoning. Methods: This was a retrospective matched database analysis of patients admitted to the ICU with acute poisoning from 2011 to 2014. It was performed in 2 ICUs within a single tertiary care hospital system. All patient information, outcomes, and costs were stored in the hospital data warehouse. Control patients were defined as randomly selected age-, sex-, severity index-, and comorbidity index-matched nonpoisoned ICU patients (1:4 matching ratio). Results: A total of 8452 critically ill patients were admitted during the study period, of whom 277 had a diagnosis of acute poisoning. The mean age was 44.5 years, and the most common xenobiotics implicated were sedative hypnotics (20.2%), antidepressants (15.2%), and opioids (10.5%). Of these, 73.6% of poisonings were deemed intentional. In-hospital mortality of poisoned patients was 5.1%, compared to 11.1% for control patients (P < .01). The median ICU length of stay (LOS) for poisoned patients was 3.0 days, compared with 4.0 days for control patients (P < .01). The mean total cost for poisoned patients was CAD$18 958. Control patients had a significantly higher mean total cost of CAD$60 628 (P < .01). The xenobiotics associated with the highest costs were acetaminophen (CAD$18 585), toxic alcohols (CAD$16 771), and opioids (CAD$12 967). Conclusions: In our cohort, we confirmed the long-held belief that patients admitted to the ICU with a primary diagnosis of poisoning have a lower mortality rate, ICU LOS, and overall cost per ICU admission than nonpoisoned patients. However, poisoned patients still accrue significant daily costs, with the highest costs attributed to xenobiotics with known antidotes, such as acetaminophen, toxic alcohols, and opioids.
Designing for low acceleration sensitivity

Recent advances in acceleration sensitivity measurement and modeling are discussed, with an emphasis on what these advances indicate in terms of designing for low acceleration sensitivity. The design suggestions are separated into two parts, namely, those that use the crystal resonator as a mechanical vibrator and those that use the crystal oscillator as an electronic circuit. Such topics as symmetry considerations, metallization, mounting etc., in both bulk acoustic wave (BAW) and surface acoustic wave (SAW) devices are discussed for the former, while for the latter the equivalent circuit modeling of crystal resonators and other loop components is addressed. <<ETX>>
Analisis konten buku teks pelajaran Fisika SMA kelas X materi pokok gerak lurus (studi pada buku karangan Drajat)

Penelitian ini menggunakan pendekatan kualitatif, yakni menguraikan, menggambarkan dan memaparkan apa adanya terhadap aspek-aspek yang diselidiki tanpa melalui prosedur statistik. Penelitian ini merupakan penelitian deskriptif analitis. Data yang terkumpul dianalisis menurut isinya (content analisys) dengan menggunakan metode interpretatif.Teknik pengumpulan data dilakukan dengan metode dokumentasi. Dokumen yang digunakan peneliti dalam penelitian ini antara lain: Buku FISIKA UNIVERSITAS/Edisi X/Jilid 1, karangan Hugh D. Young dan Roger A. Freedman, Buku FISIKA (Untuk Sains dan Teknik), Edisi 3 Jilid 1, karangan Paul A. Tipler, dan Buku FISIKA DASAR, Edisi 7 Jilid 1, karangan David Halliday, Rober Resnick, dan Jearl Walker. Hasil analisis menunjukkan bahwa konten materi gerak lurus yang disajikan buku tersebut mempunyai persentase kelayakan sebesar 83,33% pada aspek kesesuaian dengan SK dan KD (termasuk kategori sangat baik), 80% pada aspek keakuratan materi (kategori sangat baik), 72,5% pada aspek kemutakhiran dan kontekstualitas materi gerak lurus (kategori baik), dan secara keseluruhan mempunyai persentase kelayakan sebesar 78,18%, sehingga termasuk dalam kategori ”Baik. ”
The use of current loop circuit as a signal conditioner for high accuracy digital piezoresistive pressure sensors

A new topology of piezoresistive pressure sensor signal conditioner based on the alternative current loop is proposed. The optimal procedure for model parameter estimation based on the maximum likelihood method is described. The convenient calibration technique of the sensor system that enables to simplify the necessary calculations drastically is offered. The results of computer simulation confirming the theoretical result are given.
Numerical analysis of thickness shear thin film piezoelectric resonators using a laminated plate theory

Finite element matrix equations are derived from a two-dimensional, piezoelectric high frequency laminated plate theory. Two-layer ZnO/Si and three-layer ZnO/SiO/sub 2//Si thin film resonators vibrating at the fundamental thickness shear mode are investigated using the finite element models. Straight crested waves propagating in a resonator are studied. Resonant frequency, mode shapes and electromechanical coupling coefficient of the fundamental thickness shear mode are calculated and presented with respect to the C-axis orientation of the ZnO layer, and thickness ratios of the layers in a resonator. The results from the laminated plate model are checked against the three dimensional finite element solution and found to be accurate for the fundamental thickness shear and its anharmonic overtones. The plate model does not yield as accurate a frequency spectrum for flexure, face shear and extensional modes. <<ETX>>
The mathematical model and direct kinematics solution analysis of Delta parallel robot

By analyzing the mechanism of Delta parallel robot and setting up coordinate system on both static platform and moving platform, then the constraint equation and Jacob matrix can be gained. Combined with the Multi-body of Delta parallel robot built with Pro/E, and then the model is transferred to ADAMS by MECHANISM/Pro. The inverse solution and spline curves and spline function can be obtained through simulation at first, by using the result of spline curves and spline function can obtain the direct solution. This way is much easier, faster and accurately than the ways of Numerical Solution and Analytical Method. It is proved that the results can be put into practice.
Multiscale Investigation of the Depth-Dependent Mechanical Anisotropy of the Human Corneal Stroma.

PURPOSE To investigate the depth-dependent mechanical anisotropy of the human corneal stroma at the tissue (stroma) and molecular (collagen) level by using atomic force microscopy (AFM). METHODS Eleven human donor corneas were dissected at different stromal depths by using a microkeratome. Mechanical measurements were performed in 15% dextran on the surface of the exposed stroma of each sample by using a custom-built AFM in force spectroscopy mode using both microspherical (38-μm diameter) and nanoconical (10-nm radius of curvature) indenters at 2-μm/s and 15-μm/s indentation rates. Young's modulus was determined by fitting force curve data using the Hertz and Hertz-Sneddon models for a spherical and a conical indenter, respectively. The depth-dependent anisotropy of stromal elasticity was correlated with images of the corneal stroma acquired by two-photon microscopy. RESULTS The force curves were obtained at stromal depths ranging from 59 to 218 μm. At the tissue level, Young's modulus (ES) showed a steep decrease at approximately 140-μm stromal depth (from 0.8 MPa to 0.3 MPa; P = 0.03) and then was stable in the posterior stroma. At the molecular level, Young's modulus (EC) was significantly greater than at the tissue level; EC decreased nonlinearly with increasing stromal depth from 3.9 to 2.6 MPa (P = 0.04). The variation of microstructure through the thickness correlated highly with a nonconstant profile of the mechanical properties in the stroma. CONCLUSIONS The corneal stroma exhibits unique anisotropic elastic behavior at the tissue and molecular levels. This knowledge may benefit modeling of corneal behavior and help in the development of biomimetic materials.
Asymmetric cross-coupled differential pair configuration to realize neuron activation function and its derivative

In this brief, we present a new circuit technique to generate the sigmoid neuron activation function (NAF) and its derivative (DNAF). The circuit makes use of transistor asymmetry in cross-coupled differential pair to obtain the derivative. The asymmetry is introduced through external control signal, as and when required. This results in the efficient utilization of the hardware by realizing NAF and DNAF using the same building blocks. The operation of the circuit is presented in the subthreshold region for ultra low-power applications. The proposed circuit has been experimentally prototyped and characterized as a proof of concept on the 1.5-/spl mu/m AMI technology.
Quel sens les consommateurs responsables donnent-ils à leur consommation? Une approche par les récits de vie

Les préoccupations éthiques, sociales et écologiques contemporaines renouvellent la question du sens dans les pratiques de consommation. Cet article étudie le sens que les consommateurs responsables donnent à la consommation à l'aide de récits de vie analysés par une approche structurale. Les résultats permettent d'identifier des actions communes aux narrateurs: fuir le malêtre, retrouver le soi authentique, éviter l'isolement et contrôler sa vie. Trois significations à la consommation responsable sont par ailleurs mises en lumière: l'acte libératoire, l'acte politique et l'acte moral.
Immature Neurons and GABA Networks May Contribute to Epileptogenesis in Pediatric Cortical Dysplasia

Summary: Cortical dysplasia (CD), a frequent pathological substrate of pediatric epilepsy surgery patients, has a number of similarities with immature cortex, such as reduced Mg2+ sensitivity of N‐methyl‐D‐aspartate (NMDA) receptors and the persistence of subplate‐like neurons and undifferentiated cells. Because γ‐aminobutyric acid (GABA) is the main neurotransmitter in early cortical development, we hypothesized increased GABA receptor‐mediated synaptic function in CD tissue. Infrared videomicroscopy and whole‐cell patch clamp recordings were used to characterize the morphology and electrophysiological properties of immature and normal‐appearing neurons in slices from cortical tissue samples resected for the treatment of pharmacoresistant epilepsy in children (0.2–14 years). In addition, we examined spontaneous and evoked synaptic activity, as well as responses to exogenous GABA application. We demonstrate both the presence of immature pyramidal neurons and networks in young CD tissue and the predominance of GABA synaptic activity. In addition, spontaneous GABA depolarizations frequently induced action potentials, supporting a potential excitatory role of GABA in CD. Evoked synaptic responses mediated by GABA were also prominent, and bath application of 4‐aminopyridine induced rhythmic depolarizations that were blocked by bicuculline. Finally, responses to exogenous application of GABA had depolarized reversal potentials in severe compared to mild and non‐CD cases. The present data support the hypothesis that CD shares features of immature cortex, with predominant and potentially excitatory GABAA receptor‐mediated neurotransmission. These results could partially explain the increased excitability of the cortical network in pediatric CD.
Improvement of a Preliminary Design and Optimization Program for the Evaluation of Future Aircraft Projects

The improvement of an integrated aircraft predesign code and its application to future aircraft concepts is reported. For the simulation of a Megaliner canard configuration as well as a supersonic commercial transport aircraft (SCT) the predesign code PrADO was extended by the higher-order panel method HISSS. The improvement of the aerodynamic model allows the simulation of interference effects between wing, tailplane and canard as well as the extension of the simulated flight regime to supersonic speeds. The application of the calibrated predesign code to a Megaliner configuration leads to differences between published and predicted design weights below 6%. Preliminary results of the simulation of a canard configuration show that a canard may not automatically increase the aerodynamic efficiency L/D. A reduction of the induced drag is overcompensated by an increase of the minimum drag due to additional friction drag of the canard. The SCT design studies also provide converged solutions, however, a redesign of the Concorde shows significant discrepancies with respect to the operational empty weight, fields for future investigations.
Aeromonas aquariorum Is Widely Distributed in Clinical and Environmental Specimens and Can Be Misidentified as Aeromonas hydrophila

ABSTRACT Genotypic characterization of 215 Aeromonas strains (143 clinical, 52 environmental, and 20 reference strains) showed that Aeromonas aquariorum (60 strains, 30.4%) was the most frequently isolated species in clinical and water samples and could be misidentified as Aeromonas hydrophila by phenotypic methods.
Illiteracy and the incidence of Alzheimer's disease in the Yonchon County survey, Korea

ABSTRACT Background: This study aims to establish the incidence rates of Alzheimer's disease (AD) and to understand the relations between illiteracy and AD in the Korean Yonchon survey cohort. Methods: A community-based, dementia-free cohort of 966 people aged 65 years and older was followed up for an average of 5.4 ± 1.60 years to detect incident AD cases using a two-phase procedure. Age-specific incidence rates were calculated using a person-years approach with Poisson distribution confidence intervals. Data were analyzed using the Cox proportional hazards model to find the hazard ratio of illiteracy. Results: The participating percentage of the survivors was 86.4% and 74 subjects were diagnosed with AD. Incidence rates per 1000 person-years were 20.99 (95% CI 16.48 to 26.35) for AD. The hazard ratio of illiteracy was 1.78 (95% CI 1.08 to 2.93) adjusted for age, sex, educational level. AD developed more rapidly with aging in the illiterate group than in the literate group. Conclusions: Illiteracy is associated with a higher risk of AD and the risk increases with age.
Occupational asthma and IgE sensitization in a pharmaceutical company processing psyllium.

We assessed the prevalence of occupational asthma and IgE sensitization to psyllium in a pharmaceutical company producing psyllium hydrophilic mucilloid, which is used as a laxative. Workers were intermittently exposed, approximately 5 times/yr, for periods of less than 10 days. Of the 140 employees, 130 (93%) were studied before a processing period via a questionnaire spirometry (n = 125), blood sampling (n = 118), and skin prick tests (n = 120) with 7 common inhaled allergens as well as plantain and psyllium. Thirty-nine workers had a history suggestive of occupational asthma. Twenty-three of 120 (19%) showed a skin wheal diameter greater than or equal to 3 mm to psyllium and 31 of 118 (26%) had increased specific IgE antibodies; 39 (32%) workers had at least 1 of these 2 features. Subjects with a questionnaire suggestive of asthma or occupational asthma were further investigated by serial monitoring of peak expiratory flow rates and PC20 methacholine before and during the psyllium processing period. All workers had spirometry repeated during the processing period. Twenty-one subjects who had a PC20 less than or equal to 16 mg/ml (n = 10) and/or decreased their PC20 by a greater than or equal to 3.2-fold difference (n = 4) and/or changed their FEV1 by greater than or equal to 10% (n = 13) during the processing period were referred for inhalation challenges to psyllium in the laboratory. Five of the 18 workers for whom these tests were feasible gave an immediate bronchoconstrictive reaction. (ABSTRACT TRUNCATED AT 250 WORDS)
Microsatellite DNA Typing Using 16 Markers for Parentage Verification of the Korean Native Horse

This study was performed for parentage verification of the Korean native horse (KNH). 103 random KNH samples (including 19 foals for parentage testing) were genotyped by using 16 microsatellite markers. The number of alleles per locus varied from 5 to 13 with an average value of 8.56 in the KNH. The observed heterozygosity and the expected heterozygosity ranged 0.398-0.893 (the average value was 0.683) and 0.368-0.871 (the average value was 0.727) in the KNH, respectively. The PIC value and the exclusion probability ranged 0.347-0.853 (the average value was 0.692) and 0.208-0.736, respectively, and the total exclusion probability of 16 microsatellite loci was 0.9999. Of the 16 markers, AHT4, AHT5, ASB2, ASB17, HMS2, HMS3, HTG10, LEX33, TKY321 and VHL20 loci have a relatively high PIC value (>0.7) in the KNH. Of the 19 foals, 5 foals were disqualified by an incompatibility of 4-7 markers according to a Mendelian fashion in the present DNA typing for parentage testing. These results present basic information for developing a system for parentage verification and individual identification in the KNH.
Ethylene Is One of the Key Elements for Cell Death and Defense Response Control in the Arabidopsis Lesion Mimic Mutant vad11[W]

Although ethylene is involved in the complex cross talk of signaling pathways regulating plant defense responses to microbial attack, its functions remain to be elucidated. The lesion mimic mutant vad1-1 (for vascular associated death), which exhibits the light-conditional appearance of propagative hypersensitive response-like lesions along the vascular system, is a good model for studying the role of ethylene in programmed cell death and defense. Here, we demonstrate that expression of genes associated with ethylene synthesis and signaling is enhanced in vad1-1 under lesion-promoting conditions and after plant-pathogen interaction. Analyses of the progeny from crosses between vad1-1 plants and either 35S∷ERF1 transgenic plants or ein2-1, ein3-1, ein4-1, ctr1-1, or eto2-1 mutants revealed that the vad1-1 cell death and defense phenotypes are dependent on ethylene biosynthesis and signaling. In contrast, whereas vad1-1-dependent increased resistance was abolished by ein2, ein3, and ein4 mutations, positive regulation of ethylene biosynthesis (eto2-1) or ethylene responses (35S∷ERF1) did not exacerbate this phenotype. In addition, VAD1 expression in response to a hypersensitive response-inducing bacterial pathogen is dependent on ethylene perception and signaling. These results, together with previous data, suggest that VAD1 could act as an integrative node in hormonal signaling, with ethylene acting in concert with salicylic acid as a positive regulator of cell death propagation.
Operative treatment of severe chronic traumatic laryngeal stenosis in infants up to three years old.

Seven severe cases of traumatic chronic laryngeal stenosis in small children aged from 1 to 3 years, in which all other treatment had proved unsuccessful, were operated on according to Rethi's principle, with excision of scar and the use of an Aboulker prosthesis. The prosthesis was kept in position for 4 months. All patients have got rid of their tracheal cannulas. They have an unobstructed airway with no respiratory distress while playing and running. In most cases in which sectioning of the inter-arytenoid muscles was not necessary, the voice has become unexpectedly good. In the other cases the voice is also good but not sonant.