Miracle-dz/UniFAR-FTUs huggingface dataset:
Comorbidity and risk‐patterns of depression, generalised anxiety disorder and mixed anxiety‐depression in later life: results from the AMSTEL study

Depression and generalised anxiety disorder frequently overlap. The question remains unresolved whether these are specific disorders, or that they represent different dimensions of a single disorder. Although both are highly prevalent disorders in this age group, studies on this issue in the elderly are scarce. Research is needed that investigates patterns of comorbidity and possibly different risk profiles for pure depression, pure generalised anxiety and mixed anxiety‐depression in older people.
Summarization of Spoken Language Challenges, Methods, and Prospects

A crawler tracked vehicle of the type including right and left crawler tracks is provided and includes a prime mover drivingly connected to the crawler tracks through a differential, or the equivalent, as well as separate clutch and brake mechanisms interposed in the drive train for the tracks intermediate the differential and the tracks. A single oscillatable control is provided as well as a set of fluid pressure actuators for the clutch and brake mechanisms. A source of fluid under pressure is also provided and a set of fluid flow conduits communicate the source of fluid pressure with each of the actuators, independently, with a set of valves being provided and operatively associated with the fluid flow conduits for selectively controlling the flow of fluid therethrough to the corresponding actuators. The single oscillatable control and the set of valves include coacting structure for opening and closing the valves in predetermined opening and closing sequence in response to oscillation of the oscillatable control. Still further, a second set of fluid flow conduits is provided for communicating the source of fluid pressure with each of the actuators, independently, and a second set of valves is included in the second set of fluid flow conduits for selectively controlling the flow of fluid therethrough to the corresponding actuators. The single oscillatable control also coacts with the second set of valves for opening and closing the second set of valves in a second predetermined sequence different from the first mentioned sequence, in response to oscillation of the oscillatable control, a control valve being provided for selectively communicating the source of fluid under pressure with the first and second mentioned sets of fluid conduits.
Reversible interactions between smooth domains of the endoplasmic reticulum and mitochondria are regulated by physiological cytosolic Ca2+ levels

The 3F3A monoclonal antibody to autocrine motility factor receptor (AMFR) labels mitochondria-associated smooth endoplasmic reticulum (ER) tubules. siRNA down-regulation of AMFR expression reduces mitochondria-associated 3F3A labelling. The 3F3A-labelled ER domain does not overlap with reticulon-labelled ER tubules, the nuclear membrane or perinuclear ER markers and only partially overlaps with the translocon component Sec61α. Upon overexpression of FLAG-tagged AMFR, 3F3A labelling is mitochondria associated, excluded from the perinuclear ER and co-distributes with reticulon. 3F3A labelling therefore defines a distinct mitochondria-associated ER domain. Elevation of free cytosolic Ca2+ levels with ionomycin promotes dissociation of 3F3A-labelled tubules from mitochondria and, judged by electron microscopy, disrupts close contacts (<50 nm) between smooth ER tubules and mitochondria. The ER tubule-mitochondria association is similarly disrupted upon thapsigargin-induced release of ER Ca2+ stores or purinergic receptor stimulation by ATP. The inositol (1,4,5)-trisphosphate [Ins(1,4,5)P3] receptor (IP3R) colocalises to 3F3A-labelled mitochondria-associated ER tubules, and conditions that induce ER tubule-mitochondria dissociation disrupt continuity between 3F3A- and IP3R-labelled ER domains. RAS-transformed NIH-3T3 cells have increased basal cytosolic Ca2+ levels and show dissociation of the 3F3A-labelled, but not IP3R-labelled, ER from mitochondria. Our data indicate that regulation of the ER-mitochondria association by free cytosolic Ca2+ is a characteristic of smooth ER domains and that multiple mechanisms regulate the interaction between these organelles.
Systematic evaluation of observational methods assessing biomechanical exposures at work.

OBJECTIVES This systematic review aimed to identify published observational methods assessing biomechanical exposures in occupational settings and evaluate them with reference to the needs of different users. METHODS We searched scientific databases and the internet for material from 1965 to September 2008. Methods were included if they were primarily based on the systematic observation of work, the observation target was the human body, and the method was clearly described in the literature. A systematic evaluation procedure was developed to assess concurrent and predictive validity, repeatability, and aspects related to utility. At least two evaluators independently carried out this evaluation. RESULTS We identified 30 eligible observational methods. Of these, 19 had been compared with some other method(s), varying from expert evaluation to data obtained from video recordings or through the use of technical instruments. Generally, the observations showed moderate to good agreement with the corresponding assessments made from video recordings; agreement was the best for large-scale body postures and work actions. Postures of wrist and hand as well as trunk rotation seemed to be more difficult to observe correctly. Intra- and inter-observer repeatability were reported for 7 and 17 methods, respectively, and were judged mostly to be good or moderate. CONCLUSIONS With training, observers can reach consistent results on clearly visible body postures and work activities. Many observational tools exist, but none evaluated in this study appeared to be generally superior. When selecting a method, users should define their needs and assess how results will influence decision-making.
The role of aggression and violence in sport: a rejoinder to the ISSP Position Stand.

This paper is intended as a response to the International Society of Sport Psychology (ISSP) Position Stand on aggression and violence in sport (Tenenbaum, Stewart, Singer, & Duda, 1997). It challenges several arguments presented in the ISSP Position Stand. The current paper offers several counterarguments designed to clarify the real nature of aggression and violence in sport. It also suggests that the ISSP recommendations for dramatically reducing the incidence of aggression and violence in sport be radically revised and redrafted.
The Effects of Cost Sharing on the Health of Children

While many health plans have increased the proportion of costs borne by users, opponents to cost sharing fear that this may result in poorer health for children. The Rand Health Insurance Experiment examined this issue in a general population. Health outcomes of children in a free-care plan were compared with those of children in cost-sharing plans. From November 1974 through January 1982, 1,844 children between the ages of 0 and 13 were tracked. Families from six cities and counties nationwide were assigned to either a free-care health plan or to one of several cost-sharing plans for 3 to 5 years. The effects of cost sharing on measures of physiologic function, physical health, mental health, and general health perceptions were assessed. The results revealed that, for the typical child in the study, no discernible differences in health status were observed between those on the free-care plan and those on cost-sharing plans. No differences were observed among the cost-sharing plans. These findings suggest that insurance plans can be designed to shield the poor from excessive cost-sharing and preserve demand-reducing incentives for a non-aged general population without producing unacceptable health effects. (Seven appendices, 61 data tables, and nine pages of references are included.) (NB) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. *********************************************************************** The Effects of Cost Sharing on the Health of Children Robert Otto Burciaga Valdez U.S. DEPARTMENT OF EDUCATION Office of Education. ',/ Research and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) fo/his document has been reproduced as recetved from the person or organization onginating o Mmor changes have been made to improve reproduction quality. Points of view or opinions stated in this docu . ment do not necessanly represent official OERI position or pOlicy. "PERMISSION TO REPRODUCE THIS MATERIAL IN MICROFICHE ONLY HAS BEEN GRANTED BY . TO THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC). "
Automatic construction, implementation and assessment of Pettifor maps

The ability to predict the crystal structure of a material, given its constituent atoms, is one of the most fundamental problems in materials research. There exist a number of empirical methods which make predictions by clustering existing experimental data, generally using a few simple physical parameters. Although Pettifor maps are perhaps the best known and most successful of these empirical methods, the implementation and assessment of Pettifor maps has not been formalized. Here we propose well-defined algorithms for transforming data from a standard materials crystal structure database into a Pettifor map, using the map to predict the crystal structure for a new system, and assessing the predictive accuracy of the map. We introduce the idea of a candidate crystal structure list, demonstrating that by predicting more than one candidate for a new system the utility of the maps can be enhanced. We assess the accuracy of the maps by testing predictive accuracy using a cross-validation technique on all AB and A3B compounds in the CRYSTMET database. We show that for a new unknown alloy with a stable structure at the stoichiometry of the Pettifor map, a candidate list of five structures will contain the correct crystal structure for the alloy 86% of the time. The algorithms presented here can be used to automate Pettifor maps in materials crystal structure databases, making it possible for users to construct, apply and assess entirely new Pettifor maps quickly and easily.
Non Uniform Sampled signal reconstruction for software defined radio applications

This paper focuses on digital reconstruction methods of uniform signal from its non uniform samples. A specific Non Uniform Sampling (NUS) technique for controlling Analog-to-Digital Conversion (ADC) in a multi-standard radio receiver is presented. Several reconstruction algorithms are summarized and a general mathematical formula is used to describe these algorithms. Different methods are classified into two types: iterative and interpolation methods. For radio communications context, performances in terms of accuracy of reconstruction and computational complexity, are shown and compared for these algorithms.
A Novel Data Hierarchical Fusion Method for Gas Turbine Engine Performance Fault Diagnosis

Gas path fault diagnosis involves the effective utilization of condition-based sensor signals along engine gas path to accurately identify engine performance failure. The rapid development of information processing technology has led to the use of multiple-source information fusion for fault diagnostics. Numerous efforts have been paid to develop data-based fusion methods, such as neural networks fusion, while little research has focused on fusion architecture or the fusion of different method kinds. In this paper, a data hierarchical fusion using improved weighted Dempster–Shaffer evidence theory (WDS) is proposed, and the integration of data-based and model-based methods is presented for engine gas-path fault diagnosis. For the purpose of simplifying learning machine typology, a recursive reduced kernel based extreme learning machine (RR-KELM) is developed to produce the fault probability, which is considered as the data-based evidence. Meanwhile, the model-based evidence is achieved using particle filter-fuzzy logic algorithm (PF-FL) by engine health estimation and component fault location in feature level. The outputs of two evidences are integrated using WDS evidence theory in decision level to reach a final recognition decision of gas-path fault pattern. The characteristics and advantages of two evidences are analyzed and used as guidelines for data hierarchical fusion framework. Our goal is that the proposed methodology provides much better performance of gas-path fault diagnosis compared to solely relying on data-based or model-based method. The hierarchical fusion framework is evaluated in terms to fault diagnosis accuracy and robustness through a case study involving fault mode dataset of a turbofan engine that is generated by the general gas turbine simulation. These applications confirm the effectiveness and usefulness of the proposed approach.
Revolt and Protest: Student Politics and Activism in Sub-Saharan Africa

TABLE OF CONTENTS Introduction Chapter 1: Politics, students and protest Chapter 2: Student activism, structural adjustment and the 'democratic transition' Chapter 3: Researching students Chapter 4: Reform, revolt and student activism in Zimbabwe Chapter 5: Political Change and student resistance in Senegal Chapter 6: The meaning of student protest in the democratic transition Conclusion: The return of the student-intelligentsia
Trajectory Based Word Sense Disambiguation

Classifier combination is a promising way to improve performance of word sense disambiguation. We propose a new combinational method in this paper. We first construct a series of Naive Bayesian classifiers along a sequence of orderly varying sized windows of context, and perform sense selection for both training samples and test samples using these classifiers. We thus get a sense selection trajectory along the sequence of context windows for each sample. Then we make use of these trajectories to make final k-nearest-neighbors-based sense selection for test samples. This method aims to lower the uncertainty brought by classifiers using different context windows and make more robust utilization of context while perform well. Experiments show that our approach outperforms some other algorithms on both robustness and performance.
CAN REUSED COMPONENTS PROVIDE LEAD TO FUTURE DEFECTIVE COMPONENTS IN SMART GRID APPLICATIONS

Smart Grid systems are kind of System of Systems with distributed and highly heterogeneous software connected to provide various services. Early knowledge of defect prone parts is useful for improving the safety and maintenance of these kinds of systems. We report the results of an empirical study of using reused components to predict future defective components in a type of open source Smart Grid application (transmission and operation domain of Smart Grid). Our results showed that reused components of this Smart Grid application are strong predictors of future defective components. The model’s best predictors gave an average recall of 0.92 (average precision of 0.406) when tested across three future releases. Which implied that 92% of predicted defective components in the next release turned out to be defective. This model can be employed to tailor quality assurance (QA) efforts in a way that blind spots are avoided in such critical system and QA effectiveness significantly improved.
SIMPLE COLORIMETRIC ASSAY FOR MICROGRAM DETERMINATION OF BROMHEXINE HYDROCHLORIDE WITH MBTH AND 2 , 2 ’ BIPYRIDYL

The present work describes two new spectrophotometric methods for the determination of bromhexine hydrochloride in bulk and formulations. Method A is based on the reduction of Fe into Fe by the drug followed by the complex formation of Fe with 2, 2’ bipyridyl to form cherry red colored chromogen having maximum absorbance at 510nm and Method B is based on oxidation of 3-methylbenzothiazolinone-2hydrazone (MBTH) by FeCl3 followed by its coupling with the drug in acidic medium forming an intense green colored chromogen with absorbance maxima at 630nm. Beer’s law is obeyed in the range of 5-25 μg/ml with molar absorptivity of 1.113 x 10 for method A and 2-10 μg/ml with molar absorptivity of 1.128 x 10 for method B. The results were favorably compared with those obtained by reference UV spectrophotometric method. The accuracy, precision, and the linearity ranges of the methods have been determined, and they have been validated by analyzing the title drug. No interference was observed from common pharmaceutical adjuvants. These two methods were successfully applied to the pharmaceutical formulations, capsules, tablets.
Arbetsliv och Hälsa

Sophiahemmet Rehab Center AB (SRC) arbetar med Halsa, arbetslivsinriktad rehabilitering, forsakringsmedicinska utredningar, konflikthantering, psykologiskt stod, samtalsterapi, beteendeterapi, krisstod.
Towards Computational Modeling of Excitation-Contraction Coupling in Cardiac Myocytes: Reconstruction of Structures and Proteins from Confocal Imaging

Computational models of excitation-contraction (EC) coupling in myocytes are valuable tools for studying the signaling cascade that transduces transmembrane voltage into mechanical responses. A key component of these models is the appropriate description of structures involved in EC coupling, such as the sarcolemma and ion channels. This study aims at developing an approach for spatial reconstruction of these structures. We exemplified our approach by reconstructing clusters of ryanodine receptors (RyRs) together with the sarcolemma of rabbit ventricular myocytes. The reconstructions were based on dual labeling and three-dimensional (3D) confocal imaging of segments of fixed and permeabilized myocytes lying flat or on end. The imaging led to 3D stacks of cross-sections through myocytes. Methods of digital image processing were applied to deconvolve, filter and segment these stacks. Finally, we created point meshes representing RyR distributions together with volume and surface meshes of the sarcolemma. We suggest that these meshes are suitable for computational studies of structure-function relationships in EC coupling. We propose that this approach can be extended to reconstruct other structures and proteins involved in EC coupling.
Molecular dynamics simulations of the acyl‐enzyme and the tetrahedral intermediate in the deacylation step of serine proteases

Despite the availability of many experimental data and some modeling studies, questions remain as to the precise mechanism of the serine proteases. Here we report molecular dynamics simulations on the acyl‐enzyme complex and the tetrahedral intermediate during the deacylation step in elastase catalyzed hydrolysis of a simple peptide. The models are based on recent crystallographic data for an acyl‐enzyme intermediate at pH 5 and a time‐resolved study on the deacylation step. Simulations were carried out on the acyl enzyme complex with His‐57 in protonated (as for the pH 5 crystallographic work) and deprotonated forms. In both cases, a water molecule that could provide the nucleophilic hydroxide ion to attack the ester carbonyl was located between the imidazole ring of His‐57 and the carbonyl carbon, close to the hydrolytic position assigned in the crystal structure. In the “neutral pH” simulations of the acyl‐enzyme complex, the hydrolytic water oxygen was hydrogen bonded to the imidazole ring and the side chain of Arg‐61. Alternative stable locations for water in the active site were also observed. Movement of the His‐57 side‐chain from that observed in the crystal structure allowed more solvent waters to enter the active site, suggesting that an alternative hydrolytic process directly involving two water molecules may be possible. At the acyl‐enzyme stage, the ester carbonyl was found to flip easily in and out of the oxyanion hole. In contrast, simulations on the tetrahedral intermediate showed no significant movement of His‐57 and the ester carbonyl was constantly located in the oxyanion hole. A comparison between the simulated tetrahedral intermediate and a time‐resolved crystallographic structure assigned as predominantly reflecting the tetrahedral intermediate suggests that the experimental structure may not precisely represent an optimal arrangement for catalysis in solution. Movement of loop residues 216–223 and P3 residue, seen both in the tetrahedral simulation and the experimental analysis, could be related to product release. Furthermore, an analysis of the geometric data obtained from the simulations and the pH 5 crystal structure of the acyl‐enzyme suggests that since His‐57 is protonated, in some aspects, this crystal structure resembles the tetrahedral intermediate. Proteins 2002;47:357–369. © 2002 Wiley‐Liss, Inc.
Remote Vehicle Tracking System using GSM Modem and Google MAP

As the number of urban vehicles grows rapidly with the development of the economy, people are getting more concerned about vehicle theft prevention, which creates broader market prospects for vehicle anti-theft products. Various vehicle anti-theft devices have been jumped up lately, however the result is still disappointing for all kinds of devices have its drawbacks. Domestic and overseas vehicle anti-theft products are technologically classified into three categories: mechanical lock devices, car alarm system, and vehicle tracking/recovery systems, mainly aiming at preventing cars to be broken in and driven away. To address the limitations of existing vehicle tracking/alarming systems, we propose an anti-theft system mainly based on GPS and GSM system, designed and realized by integration of traditional anti-theft alarm, GPS, GSM SMS system and mobile phone android applications. The owner will receive a short message sent by GSM module as soon as the car is stolen, then he can use android mobile phone application to track down the car. Compared with traditional vehicle anti-theft systems which require customers to install software and track the location of the car on computers, our system use android mobile phone as client terminal, offering customers with more immediate, convenient and cheaper service. Additionally, since we use the free Google Map for location, which means that customers simply have to pay for WAP data traffic and SMS costs. Among them, SMS module costs less than ￥ 5. 00 monthly if the owner has ordered text message packages launched by mobile telecommunication carriers. For further development, manufacturers cooperating with mobile telecom carriers can allow customers to send and pick up messages at very low price.