Miracle-dz/UniFAR-FTUs huggingface dataset:
An Analysis of the United States Educational Administrator Shortage

There are multiple independent and interactive factors that may contribute to perceptions or misperceptions concerning an administrator shortage in the United States (US). These factors include the complexities of supply and demand data, inferential errors and over-generalisations, candidate quantity issues confounded by anecdotal accounts of candidate quality, administrator accounts of limited job desirability, and the ‘invisibility’ of women administrators as a viable candidate pool. Some researchers have begun to challenge the perception that there is an administrator or educator shortage crisis, but these voices are often readily dismissed. There are multiple reasons why portrayals of an educator shortage crisis may be widely accepted in spite of questionable evidence. Specifically there may be political and ideological reasons that misperceptions about an educator shortage may be perpetuated. This article explores reasons that may explain perceptions or misperceptions of the shortage, including political forces that may encourage or perpetuate beliefs about the problem.
Accessibility to proteases of the cytoplasmic G protein domain of vesicular stomatitis virus is increased during intracellular transport

G1 and G2 are two forms of the membrane-integrated G protein of vesicular stomatitis virus that migrate differently in gel electrophoresis because G1 is modified by high-mannose and G2 by complex-type oligosaccharide side chains. The cytoplasmic domain in G1 is less exposed to cleavage by several proteases than in G2 molecules. Acylation by palmitic acid as well as inhibition of carbohydrate processing by swainsonine and deoxynojirimycin resulted in the same pattern of proteolytic sensitivity of both glycoproteins as in untreated cells. In contrast, accessibility of the cytoplasmic domain to proteases did not change when the intracellular transport of the G protein was blocked in carbonyl cyanide m-chlorophenylhydrazone- or monensin-treated BHK-21 cells, respectively. The results suggest that the increase in accessibility of the cytoplasmic tail of the G protein occurs after the monensin block in the trans-Golgi and might reflect a conformational change of functional significance--i.e., making the cytoplasmic domain of the viral spike protein competent for its interaction with the viral core, inducing thereby the formation of the budding virus particle.
Intestinal permeability in cirrhotic patients with and without ascites

Objective. It has been suggested that increased intestinal permeability plays a pathogenic role in bacterial infections, such as spontaneous bacterial peritonitis, in patients with liver cirrhosis. The aim of this study was to assess whether intestinal permeability is altered in cirrhotic patients with and without ascites. Material and methods. Intestinal permeability was assessed by a 51Cr-EDTA permeability test in 20 cirrhotic patients (10 with and 10 without ascites) along with 20 age- and gender-matched healthy controls. In six patients with ascites, the test was performed before and after therapeutic paracentesis. Results. The median (IQR) 24-h urinary excretion of 51Cr-EDTA was higher in patients with cirrhosis (1.94% (1.21–2.70%)) compared with that in controls (1.40% (1.09–1.99%); p<0.05). Patients with (2.05% (1.50–3.46%); p<0.05) but not those without ascites (1.94% (1.13–2.53%); p>0.1) had significantly higher excretion values compared with those of controls. Only one patient without ascites and a total of four patients with ascites had increased intestinal permeability (51Cr-EDTA excretion > 95% confidence than that of controls; p>0.1). Paracentesis did not affect urinary 51Cr-EDTA excretion significantly (1.69% (1.16–2.86%) versus 1.30% (1.08–1.79%) before and after, respectively; p>0.1). No significant correlation was found between clinical severity scores for liver disease and intestinal permeability. Conclusions. Only a small proportion of patients with liver cirrhosis have increased intestinal permeability and it is unlikely that this plays any major role in predisposing these patients to infections.
Competitive Memory Training (COMET) for OCD: A Self-treatment Approach to Obsessions

Competitive Memory Training (COMET) is a cognitive intervention that aims to change the maladaptive cognitive-emotional networks underlying obsessive-compulsive disorder (OCD). COMET has not been previously tried as a self-help intervention. The present study tested the preliminary feasibility, acceptability, and effectiveness of COMET for OCD implemented as a self-help intervention. Sixty-five participants with OCD recruited through online OCD self-help fora completed an online baseline assessment including measures of OCD symptoms, self-esteem, and depression. Participants were randomly assigned to either COMET or a wait-list control group. All participants were approached 4 weeks later to complete an online post-assessment. There was no evidence for a greater decline of OCD symptoms or depression under COMET. When analyses were limited to only those participants who reported reading the entire manual at least once, self-esteem was higher at post-assessment in the COMET group. Although 78.1% of patients in the COMET group rated it as appropriate for self-administration, only 56.5% performed COMET exercises regularly and 26.4% read the entire manual at least once. The feasibility and effectiveness of COMET as a self-help internet intervention for OCD was not supported in this study. Further work is needed to better understand if modifications to our implementation of COMET may yield improved outcomes.
Confidence Intervals Make a Difference

The use of confidence intervals (CIs) as an addition or as an alternative to null hypothesis significance testing (NHST) has been promoted as a means to make researchers more aware of the uncertainty that is inherent in statistical inference. Little is known, however, about whether presenting results via CIs affects how readers judge the probability that an effect is present in the population of interest and whether a replication would be likely to reveal the same results. In the present study, 66 PhD students were asked to interpret statistical outcomes presented as CIs or as conventional statistics (t statistics and associated p values). Fewer misinterpretations of statistics—such as accepting the null hypothesis—and more references to effect size were found when results were presented as CIs. Furthermore, participants tended to be more certain about the existence of a population effect in the expected direction and about the replicability of the results when the results were presented following the conventions of NHST than when presented using CIs. Contrary to expectations, no evidence of a more precipitous drop in the belief of the existence of a population effect and replicability estimates when p values exceeded the significance level of . 05 was found when data were presented using NHST instead of by CIs.
The Interactions between the Long Non-coding RNA NERDL and Its Target Gene Affect Wood Formation in Populus tomentosa

Long non-coding RNAs (lncRNAs) are important regulatory factors for plant growth and development, but little is known about the allelic interactions of lncRNAs with mRNA in perennial plants. Here, we analyzed the interaction of the NERD (Needed for RDR2-independent DNA methylation) Populus tomentosa gene PtoNERD with its putative regulator, the lncRNA NERDL (NERD-related lncRNA), which partially overlaps with the promoter region of this gene. Expression analysis in eight tissues showed a positive correlation between NERDL and PtoNERD (r = 0.62), suggesting that the interaction of NERDL with its putative target might be involved in wood formation. We conducted association mapping in a natural population of P. tomentosa (435 unrelated individuals) to evaluate genetic variation and the interaction of the lncRNA NERDL with PtoNERD. Using additive and dominant models, we identified 30 SNPs (P < 0.01) associated with five tree growth and wood property traits. Each SNP explained 3.90–8.57% of phenotypic variance, suggesting that NERDL and its putative target play a common role in wood formation. Epistasis analysis uncovered nine SNP-SNP association pairs between NERDL and PtoNERD, with an information gain of -7.55 to 2.16%, reflecting the strong interactions between NERDL and its putative target. This analysis provides a powerful method for deciphering the genetic interactions of lncRNAs with mRNA and dissecting the complex genetic network of quantitative traits in trees.
Chronic hepatitis c in ethnic minority patients evaluated in Los Angeles county

OBJECTIVE:The aim of this study was to compare demographic, clinical, and histological features of hepatitis C in four ethnic groups seen at the Los Angeles County/University of Southern California Hepatitis Clinic.METHODS:We evaluated 256 patients with chronic hepatitis C, with 132 (52%) receiving a liver biopsy as part of their evaluation. We estimated fibrosis progression in 103 patients with known duration of disease.RESULTS:Asians (6%) were underrepresented in the hepatitis C cohort, whereas Latinos (51%) were overrepresented, as compared with the entire county population. A history of injection drug use was more frequent in whites (65%) than in African Americans (45%, p = 0.05), Latinos (47%, p = 0.01), or Asians (0%) and more frequent in Latinos (59%) than in Latinas (26%, p = 0.003). Such a gender difference was not found in African Americans or whites. Baseline laboratory values were comparable. The amount of alcohol consumed daily was higher in African Americans than in Asians (p = 0.0001) and whites (p = 0.10). African Americans (0.077 fibrosis stages/yr) and whites (0.084/yr) had significantly lower mean estimated progression of liver fibrosis than Latinos (0.215/yr) with hepatitis C virus infection (ps = 0.03 and 0.02, respectively); this was likely related to their longer estimated duration of disease.CONCLUSION:Minorities represent the majority of chronic hepatitis C cases in the Los Angeles County Hepatitis Clinic. Asians, Latinas, and African Americans are less likely to report injection drug use as a risk factor for hepatitis C virus. Latinos seem to have faster liver fibrosis progression rates than either African Americans or whites.
Neural signatures of autism

Functional magnetic resonance imaging of brain responses to biological motion in children with autism spectrum disorder (ASD), unaffected siblings (US) of children with ASD, and typically developing (TD) children has revealed three types of neural signatures: (i) state activity, related to the state of having ASD that characterizes the nature of disruption in brain circuitry; (ii) trait activity, reflecting shared areas of dysfunction in US and children with ASD, thereby providing a promising neuroendophenotype to facilitate efforts to bridge genomic complexity and disorder heterogeneity; and (iii) compensatory activity, unique to US, suggesting a neural system–level mechanism by which US might compensate for an increased genetic risk for developing ASD. The distinct brain responses to biological motion exhibited by TD children and US are striking given the identical behavioral profile of these two groups. These findings offer far-reaching implications for our understanding of the neural systems underlying autism.
UniRef clusters: a comprehensive and scalable alternative for improving sequence similarity searches

Motivation: UniRef databases provide full-scale clustering of UniProtKB sequences and are utilized for a broad range of applications, particularly similarity-based functional annotation. Non-redundancy and intra-cluster homogeneity in UniRef were recently improved by adding a sequence length overlap threshold. Our hypothesis is that these improvements would enhance the speed and sensitivity of similarity searches and improve the consistency of annotation within clusters. Results: Intra-cluster molecular function consistency was examined by analysis of Gene Ontology terms. Results show that UniRef clusters bring together proteins of identical molecular function in more than 97% of the clusters, implying that clusters are useful for annotation and can also be used to detect annotation inconsistencies. To examine coverage in similarity results, BLASTP searches against UniRef50 followed by expansion of the hit lists with cluster members demonstrated advantages compared with searches against UniProtKB sequences; the searches are concise (∼7 times shorter hit list before expansion), faster (∼6 times) and more sensitive in detection of remote similarities (>96% recall at e-value <0.0001). Our results support the use of UniRef clusters as a comprehensive and scalable alternative to native sequence databases for similarity searches and reinforces its reliability for use in functional annotation. Availability and implementation: Web access and file download from UniProt website at http://www.uniprot. org/uniref and ftp://ftp.uniprot. org/pub/databases/uniprot/uniref. BLAST searches against UniRef are available at http://www.uniprot. org/blast/ Contact: huang@dbi.udel. edu
Using pictures as vignettes to assess stages of change in weight management

Aims: To evaluate the association between descriptions of the stage of change in weight management (using pictures as vignettes) and the changes in the restriction of amount of food and body weight. The goal is to develop counselling methods for helping people to change their lifestyles. Methods: A total of 74 people at high risk of type 2 diabetes participated in six months of group counselling. The data were collected through questionnaires and video-recordings at the beginning and the end of the counselling process, and were analyzed using both deductive content analysis and statistical analysis. Results: Most of the participants were at the contemplation stage at the beginning of the study, and nearly half were at the action stage at six months. There were associations between progression in the lifestyle change process, the restriction of food amount, and weight changes. Judging from this, the descriptions of the change process of weight management using pictures were well made, because the change process progressed in parallel with the changes in weight and restriction of the amount of food eaten. Conclusions: Assessing the stages of change in weight management by using pictures as vignettes is easy to carry out, and feasible. The descriptions of the stages of change were parallel with the changes in restriction of food and changes in weight.
The Implications of Family Size for Adolescents’ Education and Work in Brazil: Gender and Birth Order Differences

Numerous studies have found a negative association between family size and children’s outcomes, particularly education. The main theoretical frameworks that explain these negative associations posit that family resources mediate the relationship between family size and children’s outcomes, and children are resource receivers only. However, societies in which adolescents often work inside and outside the household and family resources are transferred unequally undermine these assumptions. We implement a twin birth instrumental variable approach and use the nationally representative 1997–2009 PNAD data to examine the impact of family size on school enrollment, labor force, and household work in Brazil. We propose a framework for understanding the implications of family size when adolescents both receive and provide resources in the family unit and these resources may be provided and/or received unequally depending on gender and birth order. While we find no evidence of gender or birth order differences in the effects of family size on education, the results indicate strong gender and birth order differences in adolescents’ contributions to their family units. We discuss the implications of our findings for the life course of adolescents.
Computing semi-algebraic invariants for polynomial dynamical systems

In this paper, we consider an extended concept of invariant for polynomial dynamical systems (PDSs) with domain and initial condition, and establish a sound and complete criterion for checking semi-algebraic invariants (SAIs) for such PDSs. The main idea is encoding relevant dynamical properties as conditions on the high order Lie derivatives of polynomials occurring in the SAI. A direct consequence of this criterion is a relatively complete method of SAI generation based on template assumption and semi-algebraic constraint solving. Relative completeness means if there is an SAI in the form of a predefined template, then our method can indeed find one.
A Hybrid HMM/BN Acoustic Model for Automatic Speech Recognition

In current HMM based speech recognition systems, it is difficult to supplement acoustic spectrum features with additional information such as pitch, gender, articulator positions, etc. On the other hand, Bayesian Networks (BN) allow for easy combination of different continuous as well as discrete features by exploring conditional dependencies between them. However, the lack of efficient algorithms has limited their application in continuous speech recognition. In this paper we propose new acoustic model, where HMM are used for modeling of temporal speech characteristics and state probability model is represented by BN. In our experimental system based on HMM/BN model, in addition to speech observation variable, state BN has two more (hidden) variables representing noise type and SNR value. Evaluation results on AURORA2 database showed 36.4% word error rate reduction for closed noise test which is comparable with other much more complex systems utilizing effective adaptation and noise robust methods. key words: automatic speech recognition, bayesian networks, acoustic modeling, hmm
Simulating Electromagnetic Interactions in High Power Density Inverters

In high power density inverters with integrated functions like filters and control electronics electromagnetic interaction between components becomes an important issue. Especially filters for electromagnetic interference are very sensitive to electromagnetic fields and therefore critical to design. Nevertheless only few guidelines for optimizing placement of filter components were published up to now. This paper introduces a simulation method for predicting stray fields of components and conducting structures, which is verified experimentally for different passive components and setups. The examples demonstrate a possibility of handling interaction problems
The Impact of Presentation Format, Task Assignment, and Prior Knowledge on Students' Comprehension of Multiple Online Documents

This study investigated the impact of prior knowledge, writing task, and hypertext format on university students' comprehension of multisource hypertext. Fifty-two students categorized as having high or low prior knowledge studied hypertext consisting of seven component texts on the topic of social influence. Some students were given a summary writing task; others were asked to write arguments regarding the topic. Also, some students experienced the component texts organized by topic, and others experienced them introduced by source (i.e., author and date). Dependent measures included reading time and scores on a comprehension post-test as well as number and nature of connectives and number and nature of idea units included in students' essays. High knowledge students spent less time than low knowledge students and also did better on the comprehension post-test. Moreover, the argument task led to more causal connectives and more transformed information in students' papers, whereas the summary task resulted in more temporal connectives and paraphrases. Third, presentation of the material by source resulted in better macrostructural comprehension on the post-test, whereas the topic format resulted in better microstructural comprehension. Findings are discussed in terms of development of hypertext materials and task construction, and suggestions are made for further studies.
COPI selectively drives maturation of the early Golgi

COPI coated vesicles carry material between Golgi compartments, but the role of COPI in the secretory pathway has been ambiguous. Previous studies of thermosensitive yeast COPI mutants yielded the surprising conclusion that COPI was dispensable both for the secretion of certain proteins and for Golgi cisternal maturation. To revisit these issues, we optimized the anchor-away method, which allows peripheral membrane proteins such as COPI to be sequestered rapidly by adding rapamycin. Video fluorescence microscopy revealed that COPI inactivation causes an early Golgi protein to remain in place while late Golgi proteins undergo cycles of arrival and departure. These dynamics generate partially functional hybrid Golgi structures that contain both early and late Golgi proteins, explaining how secretion can persist when COPI has been inactivated. Our findings suggest that cisternal maturation involves a COPI-dependent pathway that recycles early Golgi proteins, followed by multiple COPI-independent pathways that recycle late Golgi proteins. DOI: http://dx.doi. org/10.7554/eLife.13232. 001
Protein crystallography for aspiring crystallographers or how to avoid pitfalls and traps in macromolecular structure determination

The number of macromolecular structures deposited in the Protein Data Bank now approaches 100 000, with the vast majority of them determined by crystallographic methods. Thousands of papers describing such structures have been published in the scientific literature, and 20 Nobel Prizes in chemistry or medicine have been awarded for discoveries based on macromolecular crystallography. New hardware and software tools have made crystallography appear to be an almost routine (but still far from being analytical) technique and many structures are now being determined by scientists with very limited experience in the practical aspects of the field. However, this apparent ease is sometimes illusory and proper procedures need to be followed to maintain high standards of structure quality. In addition, many noncrystallographers may have problems with the critical evaluation and interpretation of structural results published in the scientific literature. The present review provides an outline of the technical aspects of crystallography for less experienced practitioners, as well as information that might be useful for users of macromolecular structures, aiming to show them how to interpret (but not overinterpret) the information present in the coordinate files and in their description. A discussion of the extent of information that can be gleaned from the atomic coordinates of structures solved at different resolution is provided, as well as problems and pitfalls encountered in structure determination and interpretation.