Miracle-dz/UniFAR-FTUs huggingface dataset:
Noise Cancellation on ECG and Heart Rate Signals Using the Undecimated Wavelet Transform

This article describes the research carried out to eliminate the noise found in ECG signals and cardiac rhythm. The purpose to obtain clarity and reliability in the acquiring signals which can later be interpreted by a specialist. The work is based on the use of the Undecimated Wavelet Transform (UWT)[1]. In order to get a better identification of the acquired signal the Wavelet filter D6 (Daubechies) was chosen, primarily because its scaling function is closely related to the shape of the ECG, fitting very well with the applications constraints [2]. The processed signals were acquired using an amplifying board of bioelectrical signals (front-end board) and a NI PCI-6221 data acquisition board with a sampling frequency of 200 Hz. The ECG signals are obtained through the implant of electrodes connected to a channel of the frontend board. The cardiac rhythm is then obtained using an optic dactilar sensor connected to an independent channel of the ECG signal. The amplifying board was designed and developed for researching purposes on the telemedicine and signal processing area. The application to denoise the ECG signal was developed by Lab View® and is capable of graphically showing the data before and after it’s processed.
View Interpolation for Image Synthesis

Image-space simplifications have been used to accelerate the calculation of computer graphic images since the dawn of visual simulation. Texture mapping has been used to provide a means by which images may themselves be used as display primitives. The work reported by this paper endeavors to carry this concept to its logical extreme by using interpolated images to portray three-dimensional scenes. The special-effects technique of morphing, which combines interpolation of texture maps and their shape, is applied to computing arbitrary intermediate frames from an array of prestored images. If the images are a structured set of views of a 3D object or scene, intermediate frames derived by morphing can be used to approximate intermediate 3D transformations of the object or scene. Using the view interpolation approach to synthesize 3D scenes has two main advantages. First, the 3D representation of the scene may be replaced with images. Second, the image synthesis time is independent of the scene complexity. The correspondence between images, required for the morphing method, can be predetermined automatically using the range data associated with the images. The method is further accelerated by a quadtree decomposition and a view-independent visible priority. Our experiments have shown that the morphing can be performed at interactive rates on today's high-end personal computers. Potential applications of the method include virtual holograms, a walkthrough in a virtual environment, image-based primitives and incremental rendering. The method also can be used to greatly accelerate the computation of motion blur and soft shadows cast by area light sources.
17 Massively Parallel Genetic Programming

As the eld of Genetic Programming (GP) matures and its breadth of application increases, the need for parallel implementations becomes absolutely necessary. The transputer-based system presented in the chapter by Koza and Andre ([11]) is one of the rare such parallel implementations. Until today, no implementation has been proposed for parallel GP using a SIMD architecture, except for a data-parallel approach ([20]), although others have exploited workstation farms and pipelined supercomputers. One reason is certainly the apparent di culty of dealing with the parallel evaluation of di erent S-expressions when only a single instruction can be executed at the same time on every processor. The aim of this chapter is to present such an implementation of parallel GP on a SIMD system, where each processor can e ciently evaluate a di erent S-expression. We have implemented this approach on a MasPar MP-2 computer, and will present some timing results. To the extent that SIMD machines, like the MasPar are available to o er cost-e ective cycles for scienti c experimentation, this is a useful approach.
Dynamic computing random access memory

The present von Neumann computing paradigm involves a significant amount of information transfer between a central processing unit and memory, with concomitant limitations in the actual execution speed. However, it has been recently argued that a different form of computation, dubbed memcomputing (Di Ventra and Pershin 2013 Nat. Phys. 9 200–2) and inspired by the operation of our brain, can resolve the intrinsic limitations of present day architectures by allowing for computing and storing of information on the same physical platform. Here we show a simple and practical realization of memcomputing that utilizes easy-to-build memcapacitive systems. We name this architecture dynamic computing random access memory (DCRAM). We show that DCRAM provides massively-parallel and polymorphic digital logic, namely it allows for different logic operations with the same architecture, by varying only the control signals. In addition, by taking into account realistic parameters, its energy expenditures can be as low as a few fJ per operation. DCRAM is fully compatible with CMOS technology, can be realized with current fabrication facilities, and therefore can really serve as an alternative to the present computing technology.
The identity and biology of unio mancus laMarck, 1819 (=U. Elongatulus) (bivalvia: unionidae) in the Iberian Peninsula

Genetic variability, shell morphology, anatomy, reproductive season, glochidium morphology and host fish of several Iberian populations of Unio mancus Lamarck, 1819 ( ¼ U. elongatulus C. Pfeiffer, 1825) were examined. The genetics of three allopatric populations were studied, including two ‘races’ previously described for this species on the Iberian Peninsula. All shared the same haplotype of the COI mitochondrial gene. It is proposed that all known Iberian Mediterranean populations of the genus Unio correspond to Unio mancus. All mature specimens studied were dioecious. Glochidial release occurred between March and August. The barbel Barbus graellsii was the natural host of the U. mancus glochidia in the studied area. In artificial infestations performed in aquaria, seven fish species, all native, carried the glochidia throughout their complete metamorphosis. This process occurred in 141 degree/days. Newly released juveniles were spherical and had a thin marginal rim of new shell.
Smart Parking System Based on Embedded System and Sensor Network

Locating a parking space in central city areas, especially during the peak hours, is cumbersome for drivers. The issue arises from not having the knowledge of where the available spaces may be at the time, even if known, many vehicles may seek very limited parking spaces to cause severe traffic congestion. In this paper the design and implementation with a prototype of Reservation-based Smart Parking System (RSPS) that permits drivers to effectively locate and withhold the vacant parking spaces in mentioned. This system use cluster based algorithm which helps in periodically learning the parking status from the sensor networks deployed in parking spaces, the reservation service is influenced by the change of parking status. The drivers are allowed to access this said cyber-physical system with their personal communication devices. The system implemented is cost efficient smart parking system for multi-level parking facility using WSN (IR Sensor) and develop an android based application, by cluster based allocation method and performs automatic billing process. The system monitors the availability of idle parking slots and guides the vehicle to the nearest free slot. Cost is minimized by keeping the number of sensors low without sacrificing the reliability. Energy consumption of each mote is kept in check by allowing the systems to sleep periodically and by reducing their communication range. This system‟s reservation-based parking policy has the potential to smoothen the operations of parking systems, as well as mitigate traffic congestion caused by searching for parking.
Annotating Evidence Based Clinical Guidelines - A Lightweight Ontology

This paper describes a lightweight ontology for representing annotations of declarative evidence based clinical guidelines. We present the motivation and requirements for this representation, based on an analysis of several guidelines. The ontology provides the means to connect clinical questions and associated recommendations to underlying evidence, and can capture strength and quality of recommendations and evidence, respectively. The ontology was applied in the conversion of manual annotations to RDF and used as part of a prototype clinical decision support system.
Spread of Efflux Pump Overexpressing-Mediated Fluoroquinolone Resistance and Multidrug Resistance in Pseudomonas aeruginosa by using an Efflux Pump Inhibitor

Background Fluoroquinolone resistance in Pseudomonas aeruginosa may be due to efflux pump overexpression and/or target mutations. We designed this study to investigate the efflux pump mediated fluoroquinolone resistance and check the increasing effectiveness of fluoroquinolones in combination with an efflux pumps inhibitor among P. aeruginosa isolates from burn wounds infections. Materials and Methods A total of 154 consecutive strains of P. aeruginosa were recovered from separate patients hospitalized in a burn hospital, Tehran, Iran. The isolates first were studied by disk diffusion antibiogram for 11 antibiotics and then minimum inhibitory concentration (MIC) experiments were performed to detect synergy between ciprofloxacin and the efflux pump inhibitor, carbonyl cyanide-m-chlorophenyl hydrazone (CCCP). Then to elucidate the inducing of multi drug resistance due to different efflux pumps activation in Fluoroquinolone resistant isolates, synergy experiments were also performed in random ciprofloxacin resistant isolates which have overexpressed efflux pumps phenotypically, using CCCP and selected antibiotics as markers for Beta-lactams and Aminoglycosides. The isolates were also tested by polymerase chain reaction (PCR) for the presence of the MexA, MexC and MexE, which encode the efflux pumps MexAB-OprM, MexCD-OprJ and MexEF-OprN. Results Most of the isolates were resistant to 3 or more antibiotics tested. More than half of the ciprofloxacin resistant isolates exhibited synergy between ciprofloxacin and CCCP, indicating the efflux pump activity contributed to the ciprofloxacin resistance. Also increased susceptibility of random ciprofloxacin resistant isolates of P. aeruginosa to other selected antibiotics, in presence of CCCP, implied multidrug extrusion by different active efflux pump in fluoroquinolones resistant strains. All of Ciprofloxacin resistant isolates were positive for MexA, MexC and MexE genes simultaneously. Conclusion In this burn hospital, where multidrug resistant P. aeruginosa isolates were prevalent, ciprofloxacin resistance and multidrug resistance due to the overexpression of fluoroquinolones mediated efflux pumps has also now emerged. Early recognition of this resistance mechanism should allow the use of alternative antibiotics and use an efflux pumps inhibitor in combination with antibiotic therapy.
Providing R-Tree Support for MongoDB

Supporting large amounts of spatial data is a significant characteristic of modern databases. However, unlike some mature relational databases, such as Oracle and PostgreSQL, most of current burgeoning NoSQL databases are not well designed for storing geospatial data, which is becoming increasingly important in various fields. In this paper, we propose a novel method to provide R-tree index, as well as corresponding spatial range query and nearest neighbour query functions, for MongoDB, one of the most prevalent NoSQL databases. First, after in-depth analysis of MongoDB’s features, we devise an efficient tabular document structure which flattens R-tree index into MongoDB collections. Further, relevant mechanisms of R-tree operations are issued, and then we discuss in detail how to integrate R-tree into MongoDB. Finally, we present the experimental results which show that our proposed method out-performs the built-in spatial index of MongoDB. Our research will greatly facilitate big data management issues with MongoDB in a variety of geospatial information applications.
Entropic Selection of Nash Equilibrium ∗ Zeynel

This study argues that Nash equilibria with less variations in players’ best responses are more appealing. To that regard, a notion measuring such variations, the entropic selection of Nash equilibrium, is presented: For any given Nash equilibrium, we consider the cardinality of the support of a player’s best response against others’ strategies that are sufficiently close to the behavior specified. These cardinalities across players are then aggregated with a real-valued function on whose form we impose no restrictions apart from the natural limitation to nondecreasingness in order to obtain equilibria with less variations. We prove that the entropic selection of Nash equilibrium is non-empty and admit desirable properties. Some well-known games, each of which display important insights about virtues / problems of various equilibrium notions, are considered; and, in all of these games our notion displays none of the criticisms associated with these examples. These examples also show that our notion does not have any containment relations with other associated and well-known refinements, perfection, properness and persistence. Journal of Economic Literature Classification Numbers: C72
Sensing cognitive multitasking for a brain-based adaptive user interface

Multitasking has become an integral part of work environments, even though people are not well-equipped cognitively to handle numerous concurrent tasks effectively. Systems that support such multitasking may produce better performance and less frustration. However, without understanding the user's internal processes, it is difficult to determine optimal strategies for adapting interfaces, since all multitasking activity is not identical. We describe two experiments leading toward a system that detects cognitive multitasking processes and uses this information as input to an adaptive interface. Using functional near-infrared spectroscopy sensors, we differentiate four cognitive multitasking processes. These states cannot readily be distinguished using behavioral measures such as response time, accuracy, keystrokes or screen contents. We then present our human-robot system as a proof-of-concept that uses real-time cognitive state information as input and adapts in response. This prototype system serves as a platform to study interfaces that enable better task switching, interruption management, and multitasking.
Explant-Induced Reactivation of Herpes Simplex Virus Occurs in Neurons Expressing Nuclear cdk2 and cdk4

ABSTRACT Herpes simplex virus (HSV) establishes productive (lytic) infections in nonneuronal cells and nonproductive (latent) infections in neurons. It has been proposed that HSV establishes latency because quiescent neurons lack cellular factors required for productive infection. It has been further proposed that these putative factors are induced following neuronal stress, as a requirement for HSV reactivation. To date, the identity of these putative cellular factors remains unknown. We have demonstrated that cyclin-dependent kinase (cdk) 1, 2, or 7 is required for HSV replication in nonneuronal cells. Interestingly, cdks 1 and 2 are not expressed in quiescent neurons but can be induced in stressed neurons. Thus, cdks may be among the cellular proteins required for HSV reactivation whose neuronal expression is differentially regulated during stress. Herein, we determined that neuronal expression of nuclear cdk2, cdk4, and cyclins E and D2 (which activate cdks 2 and 4, respectively) was induced following explant cultivation, a stressful stimulus that induces HSV reactivation. In contrast, neuronal expression of cdk7 and cytoplasmic cdk4 decreased during explant cultivation, whereas cdk3 was detected in the same small percentage of neurons before and after explant cultivation and cdks 1, 5, and 6 were not detected in neuronal cell bodies. HSV-1 reactivated specifically in neurons expressing nuclear cdk2 and cdk4, and an inhibitor specific for cdk2 inhibited HSV-1 reactivation. We conclude that neuronal levels of cdk2 are among the factors that determine the outcome of HSV infections of neurons.
Network synchronization for dense small cell networks

Although the development of the next generation (i.e., 5G) of wireless networks is in its initial phase, it is widely agreed that some key technologies will play a vital role in the realization of 5G, such as millimeter waves, massive MIMO, small cells, and new radio air interfaces. Among these, densely deployed small cell networks are believed to be one of the most practical solutions to the 5G promise of truly ubiquitous mobile broadband. However, synchronization between densely deployed small cells is the key to the materialization of the benefits a small cell network promises, and is one of the most challenging issues of small cell networks. In this article, we overview the existing network synchronization techniques and address their limitations in small cell network deployment environments. There are two primary synchronization techniques in today's communication networks. GNSS provides the most accurate synchronization accuracy. However, due to environmental and cost limitations, GNSS may not be available in some small cell deployment scenarios (e.g., indoors). Another synchronization technique is IEEE 1588, the accuracy of which depends highly on backhaul conditions. We therefore study the feasibility of a radio-interface- based solution as a practical alternative to the synchronization problem of a dense small cell network with an application to LTE.
VALVULAR AND STRUCTURAL HEART DISEASES Case Report Transcatheter Mitral Valve-in-Ring Implantation in Prohibitive Surgical Risk Patients: Single Center Initial Experience in the United States

Surgical mitral annuloplasty ring failure can result in symptomatic mitral stenosis or regurgitation which carries significant morbidity and mortality. Reoperation carries high surgical risks and the feasibility of transcatheter mitral valve-in-ring implantation is suggested by several case reports and series. In this article, we report two MVIR procedures focusing on preprocedural planning issues and intraprocedural tips. VC 2015
A γ-2 Herpesvirus Nucleocytoplasmic Shuttle Protein Interacts with Importin α1 and α5*

Herpesvirus saimiri (HVS) is the prototype γ-2 herpesvirus. This is an increasing important subfamily of herpesviruses due to the identification of the first human γ-2 herpesvirus, Kaposi's sarcoma-associated herpesvirus. The HVS open reading frame (ORF) 57 protein is a multifunctional trans-regulatory protein homologous to genes identified in all classes of herpesviruses. Recent analysis has demonstrated that ORF 57 has the ability to bind viral RNA and to shuttle between the nucleus and cytoplasm, and is required for efficient nuclear export of viral transcripts. Here we have investigated the nucleocytoplasmic shuttling mechanism utilized by the ORF 57 protein. The yeast two-hybrid system was employed to identify interacting cellular proteins using ORF 57 as bait. We demonstrate that ORF 57 interacts with importin α isoforms 1 and 5. In addition, the binding of ORF 57 to importin α was mediated by the importin α hydrophobic internal armadillo repeats. An ORF 57 amino-terminal arginine-rich sequence, which functions as a nuclear localization sequence, was also required for this interaction. Furthermore, the ORF 57 protein is responsible for the redistribution of importin α into the nucleoli. These results identify novel cellular interactions essential for the functioning of this important herpesvirus regulatory protein.
Differential Effects of Tyrosine Kinase Inhibitors on Volume-sensitive Chloride Current in Human Atrial Myocytes

To determine whether protein tyrosine kinase (PTK) modulates volume-sensitive chloride current (ICl.vol) in human atrial myocytes and to identify the PTKs involved, we studied the effects of broad-spectrum and selective PTK inhibitors and the protein tyrosine phosphatase (PTP) inhibitor orthovanadate (VO4 −3). ICl.vol evoked by hyposmotic bath solution (0.6-times isosmotic, 0.6T) was enhanced by genistein, a broad-spectrum PTK inhibitor, in a concentration-dependent manner (EC50 = 22.4 μM); 100 μM genistein stimulated ICl.vol by 122.4 ± 10.6%. The genistein-stimulated current was inhibited by DIDS (4,4′-diisothiocyanostilbene-2,2′-disulfonic acid, 150 μM) and tamoxifen (20 μM), blockers of ICl.vol. Moreover, the current augmented by genistein was volume dependent; it was abolished by hyperosmotic shrinkage in 1.4T, and genistein did not activate Cl− current in 1T. In contrast to the stimulatory effects of genistein, 100 μM tyrphostin A23 (AG 18) and A25 (AG 82) inhibited ICl.vol by 38.2 ± 4.9% and 40.9 ± 3.4%, respectively. The inactive analogs, daidzein and tyrphostin A63 (AG 43), did not alter ICl.vol. In addition, the PTP inhibitor VO4 −3 (1 mM) reduced ICl.vol by 53.5 ± 4.5% (IC50 = 249.6 μM). Pretreatment with VO4 −3 antagonized genistein-induced augmentation and A23- or A25-induced suppression of ICl.vol. Furthermore, the selective Src-family PTK inhibitor PP2 (5 μM) stimulated ICl.vol, mimicking genistein, whereas the selective EGFR (ErbB-1) kinase inhibitor tyrphostin B56 (AG 556, 25 μM) reduced ICl.vol, mimicking A23 and A25. The effects of both PP2 and B56 also were substantially antagonized by pretreatment with VO4 −3. The results suggest that ICl.vol is regulated in part by the balance between PTK and PTP activity. Regulation is complex, however. Src and EGFR kinases, distinct soluble and receptor-mediated PTK families, have opposing effects on ICl.vol, and multiple target proteins are likely to be involved.
Cytotoxic activity of ten algae from the Persian Gulf and Oman Sea on human breast cancer cell lines; MDA-MB-231, MCF-7, and T-47D

Background: Seaweeds have proven to be a promising natural source of bioactive metabolites for drug development. Objective: This study aimed to monitor the ethanol extract of ten algae from the Persian Gulf and Oman Sea, for their in vitro cytotoxic activity on three human breast cancer cell lines. Materials and Methods: Three human breast cancer cell lines including MDA-MB-231(ER− ), MCF-7(ER + ), and T-47D (ER + ) were treated by different concentrations of total ethanol (90%) algae extracts and the cytotoxic effects were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Doxorubicin (Ebewe, Austria) was used as a positive control. After 72 h of incubation, the cytotoxic effect of the algae was calculated and presented as 50%-inhibitory concentration (IC 50 ). Results: The results indicated Gracilaria foliifera and Cladophoropsis sp. to be the most active algae in terms of cytotoxic effects on the investigated cancer cell lines. The IC 50 values against MDA-MB-231, MCF-7, and T-47D cells were, respectively, 74.89 ± 21.71, 207.81 ± 12.07, and 203.25 ± 30.98 mg/ml for G. foliifera and 66.48 ± 4.96, 150.86 ± 51.56 and >400 mg/ml for Cladophoropsis sp. The rest of the algal extracts were observed not to have significant cytotoxic effects in the concentration range from 6.25 mg/ml to 400 mg/ml. Conclusion: Our data conclusively suggest that G. foliifera and Cladophoropsis sp. may be good candidates for further fractionation to obtain novel anticancer substances. Moreover, stronger cytotoxic effects on estrogen negative breast cancer cell line (MDA-MB-231(ER− )) in comparison to estrogen positive cells (MCF-7 and T-47D) suggest that the extract of G. foliifera and Cladophoropsis sp. may have an estrogen receptor/progesterone receptor-independent mechanism for their cellular growth inhibition.