Miracle-dz/UniFAR-FTUs huggingface dataset:
O6‐methylguanine‐DNA methyltransferase gene (MGMT) expression in human glioblastomas in relation to patient characteristics and p53 accumulation

Repair of cytotoxic DNA damage by O6‐methylguanine‐DNA methyltransferase (MGMT) is a potentially important factor of chemoresistance to chloroethylnitrosoureas (CENUs), commonly used in the treatment of glioblastoma multiforme (GBM). The value of p53 as a prognostic factor in GBMs remains unclear, but a possible relationship between MGMT gene expression and p53 has been suggested. To further examine these GBM characteristics in vivo, we assessed MGMT gene expression using semi‐quantitative RT‐PCR and p53 alteration by immuno‐histochemistry on a series of 39 GBMs. MGMT gene expression was inversely correlated with age (p < 0.03), consistent with the results of others. Interestingly, tumors from male patients had higher MGMT mRNA amounts than tumors from female patients (p < 0.03). No prognostic implication was observed either for MGMT gene expression or for p53 accumulation. However, MGMT gene expression was significantly lower in p53‐altered GBM, regardless of the percentage of positive cells (p < 0.01). Our observation suggests that in human glial tumors, a low level of MGMT gene expression might promote p53 alteration, probably via mutation of its gene. Int. J. Cancer (Pred. Oncol.) 84:416–420, 1999. © 1999 Wiley‐Liss, Inc.
Impact of positron emission tomography/computed tomography and positron emission tomography (PET) alone on expected management of patients with cancer: initial results from the National Oncologic PET Registry.

PURPOSE Under Medicare's Coverage with Evidence Development policy, positron emission tomography (PET)/computed tomography (CT) and PET became covered services for previously noncovered cancer indications if prospective registry data were collected. The National Oncologic PET Registry (NOPR) was developed to meet these coverage requirements and to assess how PET affects care decisions. METHODS The NOPR collected questionnaire data from referring physicians on intended patient management before and after PET. After 1 year, the cohort included data from 22,975 studies (83.7% PET/CT) from 1,178 centers. The numbers of scans performed for diagnosis of suspected cancer (or unknown primary cancer), initial cancer staging, restaging, and suspected cancer recurrence were approximately equal. Prostatic, pancreatic and ovarian cancers represented approximately 30% of cases. RESULTS If PET data were not available, the most common pre-PET plan would have been other imaging. In these patients, the post-PET strategies changed to watching in 37% and treatment in 48%. In patients with planned biopsy before PET, biopsy was avoided in approximately 70%. If the pre-PET strategy was treatment, the post-PET strategy involved a major change in type in 8.7% and goal in 5.6%. When intended management was classified as either treatment or nontreatment, the post-PET plan was three-fold more likely to lead to treatment than nontreatment (28.3% v 8.2%; odds ratio = 3.4; 95% CI, 3.2 to 3.6). Overall, physicians changed their intended management in 36.5% (95% CI, 35.9 to 37.2) of cases after PET. CONCLUSION This large, prospective, nationally representative registry of elderly cancer patients found that physicians often change their intended management on the basis of PET scan results across the full spectrum of its potential uses.
Human action recognition via affine moment invariants

Despite their high stability and compactness, affine moment invariants have received a relatively little attention in action recognition literature. In this paper, we introduce an approach for activity recognition, based on affine moment invariants. In the proposed approach, a compact computationally-efficient shape descriptor is developed by using affine moment invariants. Affine moment invariants are derived from the 3D spatio-temporal action volume and the average image created from the 3D volume, and classified by an SVM classifier. On KTH dataset, the method achieves performance results that compare favorably with these of other contemporary approaches reported in literature.
Disappearance of aluminic bone disease in a long term asymptomatic dialysis population restricting A1(OH)3 intake: emergence of an idiopathic adynamic bone disease not related to aluminum.

In dialysis centers using reverse osmosis-treated water but not restricting A1(OH)3 administration, a high prevalence of histological aluminum bone disease has been reported. To assess whether this is also the case in our center where A1(OH)3 intake has always been restricted and even completely given up after 1980 thanks to high doses of CaCO3, we reviewed 42 bone biopsies performed between 1975 and 1985 in patients dialyzed for a mean duration of 56 months. Seventeen of these patients had been dialyzed before 1978 with softened water moderately contamined by aluminum, 15 had always been dialyzed with reverse osmosis-treated water and 10 had been exclusively treated by hemofiltration. The prevalence of aluminum bone disease in the whole population was 9.5% (4 patients) and consisted only of adynamic bone disease, osteomalacia being totally absent. When the patients dialyzed with aluminum-contaminated water were excluded as well as 1 diabetic patient who had taken A1(OH)3 for 1.5 years the prevalence of aluminum bone disease was null in this population. When the whole population is considered the prevalence of the other types of bone disease was 76% for osteitis fibrosa and 14.5% for a non-aluminic adynamic bone disease (6 cases). These latter cases differed from the osteitis fibrosa group only by a relative hypoparathyroidism not explained by higher plasma concentrations and higher oral cumulative doses of calcium, magnesium and aluminum or by lower plasma concentrations of phosphate and bicarbonate. None had previous parathyroidectomy, one had an unsuccessful transplantation and one was diabetic. Iron overload was excluded by negative Perls staining. (ABSTRACT TRUNCATED AT 250 WORDS)
Differential expression of dopaminergic cell markers in the adult zebrafish forebrain

Although the simultaneous presence of tyrosine hydroxylase (TH), aromatic amino acid decarboxylase (AADC), dopamine transporter (DAT), and vesicular monoamine transporter 2 (VMAT2) is considered as a phenotypic signature of dopamine (DA) neurons, it has been suggested that they are not uniformly expressed in all dopaminergic brain nuclei. Moreover, in nonmammalian vertebrates, two tyrosine hydroxylase genes (TH1 and TH2) are found, and they exhibit different expression patterns in zebrafish brains. Here we present a detailed description of the distribution of TH1, TH2, AADC, DAT, and VMAT2 transcripts, in relation to TH and DA immunoreactivity to better characterize dopaminergic nuclei in the adult zebrafish forebrain. TH2‐positive cells in the hypothalamus are strongly DA immunoreactive (DAir), providing direct evidence that they are dopaminergic. DAir cells are also found in most TH1‐positive or TH‐immunoreactive (THir) nuclei. However, the DAir signal was weaker than THir in the olfactory bulb, telencephalon, ventral thalamus, pretectum, and some posterior tubercular and preoptic nuclei. These cell populations also exhibited low levels of VMAT2 transcripts, suggesting that low DA is due to a lower vesicular DA accumulation. In contrast, cell populations with low levels of AADC did not always have low levels of DA. DAT transcripts were abundantly expressed in most of the TH1‐ or TH2‐positive territories. In addition, DAT and/or VMAT2 transcripts were found in some periventricular cell populations such as in the telencephalon without TH1 or TH2 expression. Thus, expression patterns of dopaminergic cell markers are not homogeneous, suggesting that the gene regulatory logic determining the dopaminergic phenotype is unexpectedly complex. J. Comp. Neurol. 519:576–598, 2011. © 2010 Wiley‐Liss, Inc.
Identification of genomic expression differences between right-sided and left-sided colon cancer based on bioinformatics analysis

Introduction More and more findings have demonstrated that right-sided colon cancers (RCC) and left-sided colon cancers (LCC) are distinct clinical and biological entities and suggest that they should be treated as different diseases. However, the reasons why RCC and LCC harbor different clinical and biological features remain unclear. Materials and methods To identify the genomic expression differences between RCC and LCC and uncover the mechanisms underlying these differences, we chose the gene expression profiles of GSE14333 from the Gene Expression Omnibus (GEO) database as an object of study. Then, a systematic and integrative bioinformatics analysis was performed to research the possible mechanism of the differentially expressed (DE) genes from the Gene Expression Omnibus dataset including gene ontology (GO) analysis, pathway enrichment analysis, protein–protein interaction (PPI) network construction, and module analysis. Totally, we extracted 3,793 DE genes from samples of colon cancer including 1,961 genes upregulated in RCC and 1,832 genes upregulated in LCC from the selected dataset. Results The results of GO and pathway enrichment analysis indicated that RCC and LCC could predispose to different pathways regulated by different genes. Based on the PPI network, PCNA, TP53, HSP90AA1, CSNK2A1, UBB, LRRK2, ABL1, PRKACA, CAV1, and JUN were identified as the key hub genes. Also, significant modules were screened from the PPI network. Conclusion In conclusion, the present study indicated that the identified genes and pathways may promote new insights into the underlying molecular mechanisms contributing to the difference between RCC and LCC and might be used as specific therapeutic targets and prognostic markers for the personalized treatment of RCC and LCC.
On automatizing recognition of multiple human activities using ultrasonic sensor grid

Human activity recognition is an important problem in health care, ambient-assisted living, surveillance-based security, etc. and has crucial applications in smart environment. A non-invasive, automated system for monitoring human activity using array of heterogeneous ultrasonic sensors has been proposed in this work. Ultrasonic sensors are widely used for distance measurement in many applications. In the proposed system experiments have been conducted using ten volunteers in a controlled laboratory environment. The data collection unit has two kinds of setups of ultrasonic sensors: the former with five HC-SR04 sensors, and the latter with four HC-SR04 ultrasonic sensors and an LV-MaxSonar-EZ0 sensor. The proposed method is found capable of detecting standing, sitting and falling of a person, and also the movements in different directions. Based on the collected data, we have performed classification analysis using multiple machine learning algorithms. The experimental results show 81% to 90% correct detection of different activities of the volunteers.
Antinociceptive Properties of Neurosteroids: A Comparison of Alphadolone and Alphaxalone in Potentiation of Opioid Antinociception

In this study, we investigated the antinociceptive and sedative effects of the opioids fentanyl, morphine, and oxycodone given alone and in combination with two neurosteroids: alphadolone and alphaxalone. An open-field activity monitor and rotarod apparatus were used to define the sedative effects caused by opioid and neurosteroid compounds given alone intraperitoneally to male Wistar rats. Dose-response curves for antinociception were constructed using only nonsedative doses of these drugs. At nonsedating doses, fentanyl, morphine, and oxycodone all caused dose-dependent tail flick latency (TFL) antinociceptive effects. Because neither neurosteroid altered TFL, electrical current was used as the test to determine doses of neurosteroid that caused antinociceptive effects at nonsedative doses. Alphadolone 10 mg/kg intraperitoneally caused significant antinociceptive effects in the electrical test but alphaxalone did not. All three opioid dose-response curves for TFL antinociception were shifted to the left by coadministration of alphadolone even though alphadolone alone had no effect on TFL. Alphaxalone given alone had no antinociceptive effects at nonsedative doses and it had no effect on opioid antinociception. Neither neurosteroid caused sedative effects when combined with opioids. We conclude that coadministration of alphadolone, but not alphaxalone, with morphine, fentanyl, or oxycodone potentiates antinociception and that this effect is not caused by an increase in sedation.
Collegiate Misuse of Prescription Stimulants: Examining Differences in Self-Worth

Background: Prescription stimulant medication is commonly used to treat attention-deficit hyperactivity disorder (ADHD). However, stimulant medication misuse is a prevalent problem among the college population. There is limited research on psychological factors associated with collegiate nonmedical stimulant misuse. Objectives: To examine the association between college students’ self-worth and stimulant medication misuse. Methods: A quantitative study implemented during the 2013–2014 academic year in which we utilized a convenience sample of undergraduate students at a public university. College students (N = 3,038) completed an electronic survey packet including a stimulant use index and the Contingencies of Self-Worth Scale. We conducted descriptive discriminant analysis (DDA) to measure the associations between four groups: Nonusers, Appropriate Users, Nonprescribed Misusuers, and Prescribed Users. Results: Significant differences in contingencies of self-worth existed between the four groups of students. Specifically, external contingencies of self-worth, such as appearance and approval, were associated with stimulant medication misuse, whereas, internal contingencies of self-worth, such as God's love and virtue, were associated with nonuse and appropriate prescribed use. Conclusions/Importance: The findings of the current study suggested contingencies of self-worth partially explain prescription stimulant misuse among the collegiate population. Addressing self-worth may be helpful in the treatment of stimulant misuse with college students.
Research of a LED lighting system based on solar energy

This paper researches a lighting control system based on lighting emitting diodes (LEDs) as lighting source, solar energy as primary source and batteries as secondary source. Maximum power point tracker (MPPT) and the battery state (charged/discharged) are contained in this system. It presents a way to charge the batteries called uniform charging method and a new type high frequency impulse LED driving circuit. This system is based on digital signal processor TMS320F2812.
Association of Proinflammatory Cytokine Gene Polymorphisms With Susceptibility to Otitis Media

OBJECTIVE. Susceptibility to otitis media results from complex interactions among genetic factors of the host, exposure to pathogens, and environmental influences. The objective of this study was to study the role of single-nucleotide polymorphisms of regulatory elements of proinflammatory cytokine genes tumor necrosis factor-α−308, interleukin-1β+3953, and interleukin-6−174, in susceptibility to recurrent otitis media in childhood. METHODS. A total of 505 children (296 otitis media susceptible, 209 nonsusceptible as control) were enrolled at 2 sites (Texas and Kentucky). DNA of the children was studied for specific single-nucleotide polymorphisms by restriction fragment length polymorphism assay and confirmed by gene sequencing. RESULTS. In the overall study group, tumor necrosis factor-α−308 and interleukin-6−174 heterozygous or homozygous polymorphisms (high cytokine-producing genotypes) were significantly associated with otitis media susceptibility. The same association was found in a match-paired subgroup of 384 subjects. In the overall study group, there was a significant step-wise increase in otitis media susceptibility with increasing number of concomitant polymorphic genotypes. Simultaneous combination of tumor necrosis factor-α−308 and interleukin-6−174 polymorphisms further increased the risk for otitis media susceptibility. These 2 polymorphic genotypes also were associated with the increased risk for tympanostomy tube placement. Children who had tumor necrosis factor-α−308 polymorphism and were breastfed for <1 month or exposed to cigarette smoke were more likely to be otitis media susceptible. CONCLUSIONS. Our data suggest that tumor necrosis factor-α−308 and interleukin-6−174 polymorphisms are associated with increased risk for otitis media susceptibility and placement of tympanostomy tubes. Environmental factors such as breastfeeding may modify the risk for otitis media susceptibility in polymorphic individuals.
UUX-Posts: a tool for extracting and classifying postings related to the use of a system

Systems Evaluation through user narratives has been a recent evaluation technique and has seen valuable results on a usability and user experience about the system. In previous work, we have researched as a user writes detailed comments about the system itself where it is online and use us to evaluate the system. However, the process of collecting and sorting user posts has become a laborious process. In this way, this article presents the UUX-Posts - A tool for extracting and classifying posts about the uses of a certain system by its users. This work contributes to UUX tests, which aim to identify Usability and UX problems by analyzing user opinions (by text).
Wideband Dual-Polarization Patch Antenna Array With Parallel Strip Line Balun Feeding

A wideband dual-polarization patch antenna array is proposed in this letter. The array is fed by a parallel strip line balun, which is adopted to generate 180° phase shift in a wide frequency range. In addition, this balun has simple structure, very small phase shift error, and good ports isolation. The working band of the antenna array is from 1.88 to 2.9 GHz with a relative bandwidth of 41.7%. The height of the antenna array is only 0. 144λ, and the cross polarization is below -20 dB. Two feeding ports are presented, which correspond to two orthogonal linear polarization. The isolation between the ports is higher than 30 dB. The simulation and measurement turns out to be similar. This antenna array can be used in TD-LTE base stations, and the design methods are also useful to other wideband microstrip antennas.
Chorioamnionitis, lung function and bronchopulmonary dysplasia in prematurely born infants

Objective To determine whether prematurely born infants exposed to chorioamnionitis compared to those not exposed have poorer lung function and are more likely to develop severe bronchopulmonary dysplasia (BPD). Design Results were analysed from consecutive infants born at <33 weeks gestation with placental histology results and lung function measurement results on days 2 and/or 7 after birth and/or at 36 weeks postmenstrual age (PMA). Setting Tertiary neonatal intensive care unit. Patients 120 infants with a median gestational age of 29 (range 23–32) weeks were studied, 76 (63%) developed BPD and 41 (34%) had been exposed to chorioamnionitis and/or funisitis. Interventions Chorioamnionitis was diagnosed histologically. Main outcome measures Lung function was assessed by measurement of lung volume and compliance and resistance of the respiratory system. If the infants remained oxygen dependent beyond 28 days, they were diagnosed at 36 weeks PMA to have mild BPD (no longer oxygen dependent), moderate BPD (required less than 30% oxygen) or severe BPD (required more than 30% oxygen and/or positive pressure support). Results No significant differences were found in the lung function results between the chorioamnionitis and non-chorioamnionitis groups at any postnatal age. There was no significant relationship between chorioamnionitis and the occurrence or severity of BPD. Regression analysis demonstrated BPD was significantly related only to birth weight, gestational age and use of surfactant. Conclusion In prematurely born infants, routinely exposed to antenatal steroids and postnatal surfactant, chorioamnionitis was not associated with worse lung function or more severe BPD.
Reliability and Construct Validity of the Iranian Version of Health-promoting Lifestyle Profile in a Female Adolescent Population

Background: Health-promoting lifestyle is receiving increasing attention concerning its prominent role in healthcare. This study examined to adapt the health-promoting lifestyle profile II culturally and to assess its psychometric properties. Methods: In this cross-sectional study, content validity was established using translation and back-translation procedures, pilot testing of the instrument, and getting views of the expert panel. Concurrent validity was estimated with Pearson's correlation between the HPLP II, the quality of life (SF-12), self-efficacy variables, and demographic variables. Construct validity was evaluated by confirmatory factor analysis (CFA). Sample size for CFA included 500 people. HPLP II reliability was estimated with Cronbach's alpha coefficients. Results: The content validity Index (CVI) surpassed 0.80 for the HPLP II and for four subscales. The CFA four-factor model represented an acceptable fit. Their factor loadings was more than 0.40. Correlations between the HPLP II and the subscales were acceptable. The relationships between the HPLP II, self-efficacy, SF-12 domain scores, and demographic variables were also significantly positive. Cronbach's α coefficient was 0.86 for the HPLP II and for the subscales ranged from 0.70 to 0.77. Conclusion: The shortened HPLP II had satisfactory psychometric properties. The revised 34-item four-factor model had perfect fit. It can be used to measure health-promoting lifestyle in the Iranian female adolescents’ population.