Miracle-dz/UniFAR-FTUs huggingface dataset:
Outpatient-Based Therapy of Oral Fludarabine and Subcutaneous Alemtuzumab for Asian Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia

Background. Intravenous alemtuzumab and fludarabine are effective in combination for the treatment of chronic lymphocytic leukemia (CLL), but require hospital visits for intravenous injection. We performed a pilot study to assess the safety and efficacy of outpatient-based oral fludarabine with subcutaneous alemtuzumab (OFSA) for the treatment of relapsed/refractory CLL. Results. Depending on their response, patients were given two to six 28-day cycles of subcutaneous alemtuzumab 30 mg on days 1,3, and 5 and oral fludarabine 40 mg/m2/day for 5 days. Median patient age was 74. The lymphocyte counts of all five patients fell after the 1st cycle of treatment and reached normal/low levels on completion of 2 to 6 cycles of therapy. Platelet counts and hemoglobin were unaffected. All five patients achieved complete hematological remission, while two attained minimal residual disease negativity on 4-color flow cytometry. Conclusions. Our OFSA regimen was effective in elderly Asian patients with relapsed/refractory CLL, and it should be investigated further.
Resting Brain Asymmetry and Affective Reactivity Aggregated Data Support the Right-Hemisphere Hypothesis

Abstract. Neuropsychological evidence has given rise to alternative models on brain asymmetry in emotion, each with different implications concerning the biological basis of individual differences in affective responses. The present study tested these implications. Resting EEG and self-reported emotions after the presentation of film clips were collected on four occasions of measurement. Subjects with greater right-sided and smaller left-sided cortical activity reported greater intensities of felt emotions after the presentation of films irrespective of valence. This finding is in line with a recent formulation of the right-hemisphere hypothesis, which proposes that the right hemisphere may play an important role in the automatic generation of emotional responses, whereas the left hemisphere may be involved in the control and modulation of emotional reactions.
Learning and Attention Problems Among Children With Pediatric Primary Hypertension

OBJECTIVE: The objective was to determine whether children with sustained primary hypertension are at increased risk for learning disabilities (LDs), as a school-related manifestation of neurocognitive problems. METHODS: A total of 201 children 10 to 18 years of age who were referred because of elevated blood pressure (BP) were included. Patients were categorized as having or not having hypertension, on the basis of BP evaluation at the initial hypertension clinic visit and subsequent confirmation of sustained elevated BP outside the clinic setting. Parents reported whether their child had a provider-confirmed LD or attention-deficit/hyperactivity disorder (ADHD). RESULTS: A total of 101 children without hypertension and 100 children with hypertension were evaluated; 18% of the children (n = 37) had LDs. In comparison with children without hypertension, children with hypertension were significantly more likely to have LDs (18% vs 9%; P < .001), irrespective of comorbid ADHD. With adjustment for demographic variables and obesity, the odds of having LDs were elevated for subjects with hypertension, in comparison with subjects without hypertension (odds ratio: 4.1 [95% confidence interval: 1.8–9.4]). CONCLUSIONS: The rate of LDs, with or without ADHD treatment, was significantly higher for children with sustained primary hypertension, compared with children without hypertension. These findings add to the growing evidence for an association between primary hypertension and cognitive function and may inform treatment and monitoring decisions for these children who may be at risk for learning problems.
Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A

The activity of the kinase Aurora-A (Aur-A) peaks during mitosis and depends on phosphorylation by one or more unknown kinases. Mitotic phosphorylation sites were mapped by mass spec sequencing of recombinant Aur-A protein that had been activated by incubation in extracts of metaphase-arrested Xenopus eggs. Three sites were identified: serine 53 (Ser-53), threonine 295 (Thr-295), and serine 349 (Ser-349), which are equivalent to Ser-51, Thr-288, and Ser-342, respectively, in human Aur-A. To ask how phosphorylation of these residues might affect kinase activity, each was mutated to either alanine or aspartic acid, and the recombinant proteins were then tested for their ability to be activated by M phase extract. Mutation of Thr-295, which resides in the activation loop of the kinase, to either alanine or aspartic acid abolished activity. The S349A mutant had slightly reduced activity, indicating that phosphorylation is not required for activity. The S349D mutation completely blocked activation, suggesting that Ser-349 is important for either the structure or regulation of Aur-A. Finally, like human Aur-A, overexpression of Xenopus Aur-A transformed NIH 3T3 cells and led to tumors in nude mice. These results provide further evidence that Xenopus Aur-A is a functional ortholog of human Aur-A and, along with the recently described crystal structure of human Aur-A, should help in future studies of the mechanisms that regulate Aur-A activity during mitotic progression.
THE VIRULENCE OF GROUP C HEMOLYTIC STREPTOCOCCI OF ANIMAL ORIGIN

A non-antigenic mucoid polysaccharide similar to that described by Kendall, Heidelberger, and Dawson was isolated from group C hemolytic streptococci. A simple method for its quantitative estimation is described. By means of this quantitative method, as well as by the direct isolation of the carbohydrates, the size and persistence of capsules in young cultures of various strains have been related to the non-antigenic mucoid polysaccharide. Similarly, invasiveness in different strains has been related to the mucoid polysaccharide. Data indicating the non-haptene nature of this material are presented. An autolytic process, accelerated by bile, is involved in the loss of capsular material from young streptococci.
Lattice sphere multiuser detection via compressive sensing

This paper presents a multiuser detection technique using compressive sensing (CS) where the entries data entries of finite-alphabet signals are considered as sparse data. Thus the proposed system is underdetermined, which pave the way for the usage of lattice sphere decoding (LSD) technique. In order to demonstrate the effectiveness of the proposed method, it is tested at different sparsity levels. We show that the proposed method provides substantial performance gain over the previous work.
Neurogenetic and morphogenetic heterogeneity in the bed nucleus of the stria terminalis

Neurogenesis and morphogenesis in the rat bed nucleus of the stria terminalis (strial bed nucleus) were examined with [3H]thymidine autoradiography. For neurogenesis, the experimental animals were the offspring of pregnant females given an injection of [3H]thymidine on 2 consecutive gestational days. Nine groups of embryos were exposed to [3H]thymidine on E13–E14, E14–E15,…E21–E22, respectively. On P60, the percentage of labeled cells and the proportion of cells originating during 24‐hour periods were quantified at six anteroposterior levels in the strial bed nucleus. On the basis of neurogenetic gradients, the strial bed nucleus was divided into anterior and posterior parts. The anterior strial bed nucleus shows a caudal (older) to rostral (younger) neurogenetic gradient. Cells in the vicinity of the anterior commissural decussation are generated mainly between E13 and E16, cells just posterior to the nucleus accumbens mainly between E15 and E17. Within each rostrocaudal level, neurons originate in combined dorsal to ventral and medial to lateral neurogenetic gradients so that the oldest cells are located ventromedially and the youngest cells dorsolaterally. The most caudal level has some small neurons adjacent to the internal capsule that originate between E17 and E20. In the posterior strial bed nucleus, neurons extend ventromedially into the posterior preoptic area. Cells are generated simultaneously along the rostrocaudal plane in a modified lateral (older) to medial (younger) neurogenetic gradient. Ventrolateral neurons originate mainly between E13 and E16, dorsolateral neurons mainly between E15 and E16, and medial neurons mainly between E15 and E17. The youngest neurons are clumped into a medial “core” area just ventral to the fornix.
A Functional Perspective on the Justice Judgment Process and Its Consequences [Een Functioneel Perspectief op het Rechtvaardigheidsbeoordelingsproces en Haar Consequenties]

Dit proefschrift heeft zich gericht op de functionaliteit van rechtvaardigheidbeoordelingen en de gevolgen voor gedrag (zoals hulpgedrag) en andere reacties (zoals voor het aandachtssysteem en rechtvaardigheidsgevoeligheid). De studies in dit proefschrift laten zien dat mensen gebruik maken van rechtvaardigheid in hun communicatie om instrumentele redenen en dat rechtvaardigheid in communicatie functioneert als een overtuigende kracht. Bovendien heb ik laten zien dat rechtvaardigheid automatisch aandacht kan trekken en vasthouden en dat het observeren of ervaren van rechtvaardige en onrechtvaardige situaties mensen gevoeliger maakt voor rechtvaardigheid. Deze bevindingen leveren belangrijke inzichten voor hoe mensen zichzelf presenteren en voor hoe we die presentaties kunnen interpreteren. Bijvoorbeeld, mensen die een klacht indienen zullen het gebruik van rechtvaardigheidsclaims vermijden. Dat betekent echter niet dat ze de uitkomsten of procedures eerlijk vinden. Vanwege de omvangrijke gevolgen van ervaringen van onrecht is het belangrijk hier aandacht aan te besteden. Omgekeerd, wanneer mensen anderen willen overtuigen van het onrecht dat heeft plaatsgevonden, doet men er verstandig aan te benadrukken geen eigenbelang na te streven.
The Crimes of Crime Labs

In November 2005, a man was convicted in New York City for a thirty-two-year-old rape. The circumstances were quite unusual, even for cold cases. The original 1974 trial had ended in a hung jury, and the defendant had jumped bail before his scheduled re-trial. He was apprehended in 2004 in Georgia on another charge, and a background check disclosed the open New York warrant. The crucial difference between the 1974 and 2005 trials was DNA evidence recovered from the underpants which the victim wore on the day of the crime, “found stuffed in the files in the Manhattan district attorney’s cold case unit. ”
Long-term changes in plasma anti-Müllerian hormone concentration and the relationship with superovulatory response in Japanese Black cattle

The concentration of circulating anti-Müllerian hormone (AMH) in cattle is a useful endocrine marker for ovarian response to superovulation. Although the AMH concentration undergoes little variation throughout the estrous cycle, its long-term changes remain incompletely understood. Here, we investigated the relationship between superovulation response and plasma AMH concentration in Japanese Black cattle and the long-term changes in plasma AMH concentration of embryo donor cows and heifers. The median, 25th percentile, and 75th percentile of AMH concentrations in 222 mature animals were 0.265, 0.118, and 0.488 ng/ml, respectively. The numbers of ova/embryos, fertilized embryos, and transferable embryos in a total of 295 superovulations were significantly different among the H (AMH ≥ 0.488 ng/ml), M (AMH 0.487–0.119 ng/ml), and L (AMH ≤ 0.118 ng/ml) groups. AMH concentrations during repeated superovulation in ten donor cows were significantly decreased after the third treatment. In heifers, the highest AMH concentration was observed in individuals during 2–13 months of age, with considerable individual variability. AMH concentrations of heifers at 10 or 11 months correlated with the number of ova/embryos during superovulation at 13–18 months (r = 0.641, P < 0.05). These results suggest that the 25th and 75th percentile values of AMH concentration would give a useful rough estimate of ovarian response; however, repeated superovulation may reduce the predictive accuracy of single measurements of AMH concentration. It would be possible to evaluate AMH concentration in heifers after approximately 11 months of age.
Does Ethics Have a Chance in a World of Consumers

* Introduction: Threats or Chances? * What Chance of Ethics in the Globalized World of Consumers? * Categorial Murder, or the Legacy of the Twentieth Century and How to Remember It * Freedom in the Liquid-Modern Era * Hurried Life, or Liquid-Modern Challenges to Education * Out of the Frying Pan and into the Fire, or the Arts between Administration and the Markets * Making the Planet Hospitable to Europe * Notes * Index
Social Network Characteristics and Daily Smoking among Young Adults in Sweden

A large number of studies have shown that friends’ smoking behavior is strongly associated with an individual’s own risk for smoking. However, few studies have examined whether other features of social networks, independently or conjointly with friends’ smoking behavior, may influence the risk for smoking. Because it is characterized by the growing importance of friendship networks, the transition from adolescence to young adulthood may constitute a particularly relevant period on which to focus our investigation of network influences on smoking behavior. The aim of this study was therefore to examine the consequences of peer smoking as well as other network characteristics (friends’ other health behaviors, relationship content, and structural aspects of the network) on the risk for smoking among young adults. The data was based on a cross-sectional survey of Swedish 19-year-olds carried out in 2009 (n = 5,695) with a response rate of 51.6%. Logistic regression was the primary method of analysis. The results show that having a large percentage of smokers in one’s network was by far the most important risk factor for daily smoking. The risk of daily smoking was 21.20 (CI 14.24. 31.54) if 76%–100% of the network members smoked. Having a high percentage of physically active friends was inversely associated with daily smoking. The risk of smoking was 0.65 (CI 0.42. 1.00) if 76%–100% of the network members were physically active. No main associations between the other network characteristics (relationship content and structural aspects of the network) and smoking were found. However, there was an interaction between the percentage of smokers in the network and relationship content (i.e., trust, relationship quality and propensity to discuss problems): positive relationship content in combination with peer smoking may increase the risk of smoking. Women with a high percentage of smokers in their networks were also at higher risk of daily smoking than were men with many smoking friends. Hence, it is important to consider the interplay between peer smoking and other network characteristics on the risk of smoking, where features of networks which traditionally are seen as constructive may occasionally provide the impetus to smoke. Future studies should use longitudinal data to study whether these findings reflect peer selection or peer influence.
Comparison of Quasielastic Light Scattering and Laser Diffractometry as Nondestructive Probes into the Structure of Bacillus sphaericus Spores Produced at Different Temperatures

Volume 62, no. 5, p. 1702, column 2, equation 3: the equation should read as follows. g(sup1)((tau)) = [g(sup2)((tau)) - 1](sup1/2) = exp[-K(sup2)(D(inf1) cos(sup2)(alpha) + D(inf2) sin(sup2)(alpha))(tau)] (3) [This corrects the article on p. 1699 in vol. 62. ].
A Qualitative Collective Case Study Investigating the Motivational Factors of Elementary-Aged Students in Physical Education Class and Leisurely Physical Activity

The purpose of this qualitative collective case study was to increase understanding of the influential motivating factors of elementary-aged students in physical education (PE) that foster positive reinforcement to manage student engagement. The study was conducted at three different elementary schools in a school district in the southeastern United States. To determine the factors that influence the students’ motivation in PE and leisurely physical activity, a set of data collection sources was used. Student interviews, caregiver surveys, and teacher journal entries were utilized to collect purposeful data that identified the specific factors associated with participation. Data was then transcribed and coded to identify reoccurring themes across the cases. The study found multiple factors associated with PE engagement and leisurely physical activity involvement, which are: (a) incentives play a role in motivation; (b) organized and leisurely physical activity foster positive relationships among peers; (c) bullying negatively affects students’ motivation; (d) leisurely family activities foster higher engagement levels in children; (e) access to parks, recreational facilities, and youth sports leagues play a role in leisurely physical activity levels; (f) caregivers’ involvement in their child’s education allows communication between teacher and caregiver to strengthen the PE program; (g) the effectiveness of the classroom management of the teacher ensures all students are provided with an education that is safe and fair; (h) the teacher’s ability to use incentives appropriately increases the likelihood of the most desirable behaviors; and (i) consistent school-wide application of the PBIS model reinforces positive student outcomes.
Do 0–10 Numeric Rating Scores Translate into Clinically Meaningful Pain Measures for Children?

BACKGROUND:Self-reported pain scores are used widely in clinical and research settings, yet little is known about their interpretability in children. In this prospective, observational study we evaluated the relationship between 0 to 10 numerical rating scale (NRS) pain scores and other self-reported, clinically meaningful outcomes, including perceived need for medicine (PNM), pain relief (PR), and perceived satisfaction (PS) with treatment in children postoperatively. METHODS:This study included children ages 7 to 16 years undergoing surgery associated with postoperative pain. One to 4 observations were recorded in each child within the first 24 hours postoperatively. At each assessment, children rated their pain with the NRS, stated their PNM, and rated their satisfaction with pain management. Assessments were repeated within 1 to 2 hours, and children additionally rated their PR as the same, better, or worse in comparison with the earlier assessment. Receiver operator characteristic curves were developed to examine potential NRS cut-points for PNM and PS, and the minimum clinically significant difference (MCSD) in pain score associated with PR was calculated. RESULTS:Three hundred ninety-seven observations (including 189 pairs) were recorded in 113 children. NRS scores associated with PNM were significantly higher than “no need” (median 6 vs. 3; P < 0.001). NRS scores >4 had good sensitivity (0.81) and specificity (0.70) to discriminate PNM, but with a large number of false positives and negatives (e.g., 42% of children with scores >4 did not need analgesia). The MCSD in NRS scores was −1 (95% confidence interval [CI] −0.5 to 1) or +1 (CI 0.5 to 2.7) in relation to feel “a little better” or “worse,” respectively (P < 0.001 vs. the same). NRS scores >6 had a sensitivity of 0.82 and specificity of 0.76 in discriminating dissatisfaction with treatment, yet 46% and 24% of children with scores >6, respectively, were somewhat to very satisfied with their analgesia. CONCLUSIONS:This study provides important information regarding the clinical interpretation of NRS pain scores in children. Data further support the NRS as a valid measure of pain intensity in relation to the child's PNM, PR, and PS in the acute postoperative setting. However, the variability in scores in relation to other clinically meaningful outcomes suggests that application of cut-points for individual treatment decisions is inappropriate.
Linear-Time Approximation Algorithms for Geometric Intersection Graphs

Numerous approximation algorithms for problems on geometric intersection graphs have been proposed in the literature, exhibiting a sharp trade-oﬀ between running times and approximation ratios. We introduce a method to obtain linear-time constant-factor approximation algorithms for such problems. To illustrate its applicability, we obtain results for three well-known optimization problems on two classes of geometric intersection graphs. Among such results, our method yields linear-time (4+ ε )-approx- imations for the maximum-weight independent set and the minimum dominating set of unit disk graphs, thus bringing dramatic performance improvements when compared to previous algorithms that achieve the same approximation ratios
Need a Fleet? Use the Force!

1 Prologue The theme of this paper, and the main motivation for writing it, was pro us by Professor Chew Becca, from the Tattooine University, who was vis Department a few months ago. He presented us with a problem that seem — to him — of the greatest practical importance. His stay at our Departm too brief for us to completely solve the problem, but we are reporting her progress that we have made after his visit. Prof. Becca's problem was apparently simple. As is, by now, well kn Rebels had infiltrated an important Imperial base with one of their best a call him Lucky Skywalker. Due to the chronic shortage of vessels that the Rebel's fleet at the time, Lucky's mission was to " appropriate " the possible number of Imperial ships and send them, without them being inte through a large extension of Empire-controlled space. The ultimate destin the ships was to be a secret Rebel base, where the ships were to be rewor were to become part of the Rebel fleet. However, Lucky's mission was placed under a few other constraints. T would have to escape unnoticed by the Imperials, always proceeding in fleet formation, and they could have no crew on board, since no other age available. Furthermore, the ships could not communicate with each other, the risk of their radio communication being intercepted. Worst of all, to further strengthen his grip on the entire universe, the Dark Emperor had had his latest operating system, Windows 3000, installed on the navi computers of all the ships in the Imperial fleet. This left no available me the computers to use as storage for an auto-pilot algorithm. Finally, the Re not want to provide the coordinates of their secret base to the auto-pilot Empire then could have traced them and attacked the base in force.
Engineering two-photon high-dimensional states through quantum interference

A simple approach to preparing high-dimensional entangled states by quantum interference. Many protocols in quantum science, for example, linear optical quantum computing, require access to large-scale entangled quantum states. Such systems can be realized through many-particle qubits, but this approach often suffers from scalability problems. An alternative strategy is to consider a lesser number of particles that exist in high-dimensional states. The spatial modes of light are one such candidate that provides access to high-dimensional quantum states, and thus they increase the storage and processing potential of quantum information systems. We demonstrate the controlled engineering of two-photon high-dimensional states entangled in their orbital angular momentum through Hong-Ou-Mandel interference. We prepare a large range of high-dimensional entangled states and implement precise quantum state filtering. We characterize the full quantum state before and after the filter, and are thus able to determine that only the antisymmetric component of the initial state remains. This work paves the way for high-dimensional processing and communication of multiphoton quantum states, for example, in teleportation beyond qubits.