Miracle-dz/UniFAR-FTUs huggingface dataset:
Virulence Profiles, Phylogenetic Background, and Antibiotic Resistance of Escherichia coli Isolated from Turkeys with Airsacculitis

Avian Pathogenic Escherichia coli (APEC) has been studied for decades because of its economic impact on the poultry industry. Recently, the zoonotic potential of APEC and multidrug-resistant strains have emerged. The aim of this study was to characterize 225 APEC isolated from turkeys presenting airsacculitis. The results showed that 92% of strains presented a multidrug-resistance (MDR), and the highest levels of resistance were to sulfamethazine (94%) and tetracycline (83%). Half of these strains were classified in phylogenetic group B2, followed by B1 (28.6%), A (17.1%), and D (4.8%). The prevalence of virulence genes was as follows: salmochelin (iroN, 95%), increased serum survival (iss, 93%), colicin V (cvi/cva, 67%), aerobactin (iucD, 67%), temperature-sensitive haemagglutinin (tsh, 56%), iron-repressible protein (irp2, 51%), invasion brain endothelium (ibeA, 31%), vacuolating autotransporter toxin (vat, 24%), K1 antigen (neuS, 19%), enteroaggregative heat-stable cytotoxin (astA, 17%), and pilus associated with pyelonephritis (papC, 15%). These results demonstrate that the majority of the investigated strains belonged to group B2 and were MDR. These data suggest that turkeys may serve as a reservoir of pathogenic and multidrug-resistance strains, reinforcing the idea that poultry plays a role in the epidemiological chain of ExPEC.
An Authorization Model for Multi-Provider Queries

We present a novel approach for the specification and enforcement of authorizations that enables controlled data sharing for collaborative queries in the cloud. Data authorities can establish authorizations regulating access to their data distinguishing three visibility levels (no visibility, encrypted visibility, and plaintext visibility). Authorizations are enforced in the query execution by possibly restricting operation assignments to other parties and by adjusting visibility of data on-the-fly. Our approach enables users and data authorities to fully enjoy the benefits and economic savings of the competitive open cloud market, while maintaining control over data.
Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice

Antidepressant-like effects of ethanolic extract of Hericium erinaceus (HE) mycelium enriched in erinacine A on depressive mice challenged by repeated restraint stress (RS) were examined. HE at 100, 200 or 400 mg/kg body weight/day was orally given to mice for four weeks. After two weeks of HE administration, all mice except the control group went through with 14 days of RS protocol. Stressed mice exhibited various behavioral alterations, such as extending immobility time in the tail suspension test (TST) and forced swimming test (FST), and increasing the number of entries in open arm (POAE) and the time spent in the open arm (PTOA). Moreover, the levels of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) were decreased in the stressed mice, while the levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α were increased. These changes were significantly inverted by the administration of HE, especially at the dose of 200 or 400 mg/kg body weight/day. Additionally, HE was shown to activate the BDNF/TrkB/PI3K/Akt/GSK-3β pathways and block the NF-κB signals in mice. Taken together, erinacine A-enriched HE mycelium could reverse the depressive-like behavior caused by RS and was accompanied by the modulation of monoamine neurotransmitters as well as pro-inflammatory cytokines, and regulation of BDNF pathways. Therefore, erinacine A-enriched HE mycelium could be an attractive agent for the treatment of depressive disorders.
Electrical transport in titania nanoparticles embedded in conducting polymer matrix

Abstract Conducting polymer-wide band gap semiconductor nanocomposites are prepared by polymerizing pyrrole in the presence of colloidal titanium dioxide (TiO2) sol. Characterizations of nanocomposites are carried out by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and X-ray diffraction (XRD). Direct current (dc) and alternating current (ac) conductivities of nanocomposites have been investigated as a function of temperature and frequency for different concentrations of polypyrrole (PPY). The temperature dependence of ac conductivity suggests that small polaron tunneling occurs in the charge transfer process. A very large dielectric constant of about 13,000 at room temperature has been observed. The interface between PPY and TiO2 plays an important role in yielding a large dielectric constant in the composite.
Factors Associated with Postpartum Maternal Functioning in Women with Positive Screens for Depression.

BACKGROUND Functional assessment may represent a valuable addition to postpartum depression screening, providing a more thorough characterization of the mother's health and quality of life. To the authors' knowledge, this analysis represents the first examination of postpartum maternal functioning, as measured by a patient-centered validated tool aimed at ascertainment of functional status explicitly, and its clinical and sociodemographic correlates. MATERIALS AND METHODS A total of 189 women recruited from a large, urban women's hospital in the northeastern United States who both (1) screened positive for depression between 4 and 6 weeks postpartum and (2) completed a subsequent home (baseline) visit between October 1, 2008, and September 4, 2009, were included in this analysis. Multiple linear regression was conducted to ascertain which clinical and sociodemographic variables were independently associated with maternal functioning. RESULTS The multivariate analysis revealed independent associations between bipolar status, atypical depression, depression score (17-item Hamilton Rating Scale for Depression), and insurance type with postpartum maternal functioning. The beta coefficient for bipolar status indicates that on average we would expect those with bipolar disorder to have maternal functioning scores that are 5.6 points less than those without bipolar disorder. CONCLUSIONS Healthcare providers treating postpartum women with complicating mental health conditions should be cognizant of the potential ramifications on maternal functioning. Impaired functioning in the maternal role is likely to impact child development, although the precise nature of this relationship is yet to be elucidated.
Identification of Proteins Involved in Carbohydrate Metabolism and Energy Metabolism Pathways and Their Regulation of Cytoplasmic Male Sterility in Wheat

Cytoplasmic male sterility (CMS) where no functional pollen is produced has important roles in wheat breeding. The anther is a unique organ for male gametogenesis and its abnormal development can cause male sterility. However, the mechanisms and regulatory networks related to plant male sterility are poorly understood. In this study, we conducted comparative analyses using isobaric tags for relative and absolute quantification (iTRAQ) of the pollen proteins in a CMS line and its wheat maintainer. Differentially abundant proteins (DAPs) were analyzed based on Gene Ontology classifications, metabolic pathways and transcriptional regulation networks using Blast2GO. We identified 5570 proteins based on 23,277 peptides, which matched with 73,688 spectra, including proteins in key pathways such as glyceraldehyde-3-phosphate dehydrogenase, pyruvate kinase and 6-phosphofructokinase 1 in the glycolysis pathway, isocitrate dehydrogenase and citrate synthase in the tricarboxylic acid cycle and nicotinamide adenine dinucleotide (NADH)-dehydrogenase and adenosine-triphosphate (ATP) synthases in the oxidative phosphorylation pathway. These proteins may comprise a network that regulates male sterility in wheat. Quantitative real time polymerase chain reaction (qRT-PCR) analysis, ATP assays and total sugar assays validated the iTRAQ results. These DAPs could be associated with abnormal pollen grain formation and male sterility. Our findings provide insights into the molecular mechanism related to male sterility in wheat.
Physical Education and Blood Lipid Concentrations in Children: The LOOK Randomized Cluster Trial

Background and Objectives Elevated blood lipids during childhood are predictive of dyslipidemia in adults. Although obese and inactive children have elevated values, any potentially protective role of elementary school physical education is unknown. Our objective was to determine the effect of a modern elementary school physical education (PE) program on the blood lipid concentrations in community-based children. Methods In this cluster-randomized controlled trial, 708 healthy children (8.1±0.3 years, 367 boys) in 29 schools were allocated to either a 4-year intervention program of specialist-taught PE (13 schools) or to a control group of the currently practiced PE conducted by generalist classroom teachers. Fasting blood lipids were measured at ages 8, 10, and 12 years and intervention and control class activities were recorded. Results Intervention classes included more fitness work and more moderate and vigorous physical activity than control classes (both p<0.001). With no group differences at baseline, the percentage of 12 year-old boys and girls with elevated low density lipoprotein cholesterol (LDL-C, >3.36mmol.L−1,130 mg/dL) was lower in the intervention than control group (14% vs. 23%, p = 0.02). There was also an intervention effect on mean LDL-C across all boys (reduction of 9.6% for intervention v 2.8% control, p = 0.02), but not girls (p = 0.2). The intervention effect on total cholesterol mirrored LDL-C, but there were no detectable 4-year intervention effects on high-density lipoprotein cholesterol or triglycerides. Conclusions The PE program delivered by specialist teachers over four years in elementary school reduced the incidence of elevated LDL-C in boys and girls, and provides a means by which early preventative practices can be offered to all children. Trial Registration Australia New Zealand Clinical Trial Registry ANZRN12612000027819 https://www.anzctr. org.au/Trial/Registration/TrialReview.aspx? id=347799.
alkaline electrolyzed water ( AEW ) on harvesting

21 Microalgae hold promise as a renewable energy source for the production of biofuel, 22 as they can convert light energy into chemical energy through photosynthesis. However, cost23 efficient harvest of microalgae remains a major challenge to commercial-scale algal biofuel 24 production. We firstly investigated the potential of electrolytic water as a flocculant for 25 harvesting Tetraselmis sp. Alkaline electrolytic water (AEW) is produced at cathode through 26 water electrolysis. It contains mineral ions such as Na, K, Ca and Mg that can act as 27 flocculant. The flocculation activity with AEW was evaluated via culture density, AEW 28 concentration, medium pH, settling time, and ionic strength. The flocculation efficiency was 29 88.7% at 20% AEW (pH 8, 10 min) with a biomass concentration of 2 g/L. Initial biomass 30 concentration and medium pH had significant influences on the flocculation activity of AEW. 31 A viability test of flocculated microalgal cells was conducted using Evans blue stain, and 32 cells appeared intact. Furthermore, the growth rate of Tetraselmis sp. in recycled flocculation 33 medium was similar to the growth rate in fresh F/2 medium. Our results suggested that AEW 34 flocculation could be very useful and affordable methodology for fresh biomass harvesting 35 with environmentally friendly easy operation in part of algal biofuel process. 36
Alcohol advertising in magazines and adolescent readership.

CONTEXT Adolescent drinking is a major public health concern. The federal government does not restrict alcohol advertising to adolescents, but relies on the alcohol industry for self-regulation. OBJECTIVES To investigate recent alcohol advertising in magazines and to determine whether advertising frequency is associated with adolescent readership. DESIGN, SETTING, AND SUBJECTS All alcohol advertisements were counted that appeared from 1997-2001 in 35 of 48 major US magazines, which tracked their adolescent readership (3 refused all alcohol advertisements; and advertisement counts were unavailable for 10). Variation was assessed in the advertisement placement frequency for each major category of alcohol (beer, wine and wine coolers, and distilled liquor) by a magazine's adolescent readership (age 12-19 years), young adult readership (age 20-24 years), and older adult readership (age > or =25 years); readership demographics (sex, race, and income); year; frequency of publication; and cost per advertisement. MAIN OUTCOME MEASURE Variation in alcohol advertising frequency by adolescent readership. RESULTS Adolescent readership ranged from 1.0 to 7.1 million. The alcohol industry placed 9148 advertisements at a cost of 696 million dollars. Of the 9148 advertisements, 1201 (13%) were for beer, 443 (5%) for wine, and 7504 (82%) for liquor. After adjustment for other magazine characteristics, the advertisement rate ratio was 1.6 times more for beer (95% confidence interval [CI], 1.0-2.6; P =.05) and liquor (95% CI, 1.1-2.3; P =.01) for every additional million adolescent readers. Wine industry advertising was not associated with adolescent readership. CONCLUSIONS Magazine advertising by the beer and liquor industries is associated with adolescent readership. Industry and federal policymakers should examine ways to regulate advertising that reaches large numbers of adolescents.
Efficacy, Safety, and Timing of Anticoagulant Thromboprophylaxis for the Prevention of Venous Thromboembolism in Patients With Acute Spinal Cord Injury: A Systematic Review

Study Design: Systematic review. Objectives: The objective of this study was to answer 5 key questions: What is the comparative effectiveness and safety of (1a) anticoagulant thromboprophylaxis compared to no prophylaxis, placebo, or another anticoagulant strategy for preventing deep vein thrombosis (DVT) and pulmonary embolism (PE) after acute spinal cord injury (SCI)? (1b) Mechanical prophylaxis strategies alone or in combination with other strategies for preventing DVT and PE after acute SCI? (1c) Prophylactic inferior vena cava filter insertion alone or in combination with other strategies for preventing DVT and PE after acute SCI? (2) What is the optimal timing to initiate and/or discontinue anticoagulant, mechanical, and/or prophylactic inferior vena cava filter following acute SCI? (3) What is the cost-effectiveness of these treatment options? Methods: A systematic literature search was conducted to identify studies published through February 28, 2015. We sought randomized controlled trials evaluating efficacy and safety of antithrombotic strategies. Strength of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Results: Nine studies satisfied inclusion criteria. We found a trend toward lower risk of DVT in patients treated with enoxaparin. There were no significant differences in rates of DVT, PE, bleeding, and mortality between patients treated with different types of low-molecular-weight heparin or between low-molecular-weight heparin and unfractionated heparin. Combined anticoagulant and mechanical prophylaxis initiated within 72 hours of SCI resulted in lower risk of DVT than treatment commenced after 72 hours of injury. Conclusion: Prophylactic treatments can be used to lower the risk of venous thromboembolic events in patients with acute SCI, without significant increase in risk of bleeding and mortality and should be initiated within 72 hours.
Flexible Optical Fiber Fabry–Perot Interferometer Based Acoustic and Mechanical Vibration Sensor

We have proposed and demonstrated a novel flexible optical fiber Fabry–Perot interferometer (FPI) based vibration sensor with broadband frequency response. The sensor consists of a flexible FP cavity formed by soft splicing using polydimethylsiloxane (PDMS) material with low Young's Modulus and a compact fiber cantilever of low moment inertia as the vibration receiver. Acoustic or mechanical waves experienced by the fiber cantilever can result in obvious change of the FPI cavity length and finally be transduced to the intensity variation of the sensor signal, which makes the sensor highly sensitive to external acoustic or mechanical vibrations. Taking advantage of the superior elasticity of PDMS and compact structure of cantilever, a broadband frequency response for vibration detection has been achieved together with high sensitivity without extra external vibration receiver. The vibration detection is theoretically analyzed, and acoustic vibrations up to 20 kHz and damped mechanical vibrations from tens of hertz to tens of kilohertz, covering both the sound and part of ultrasound range, have been experimentally detected. Moreover, each event of the ball hitting and rebounding has been accurately identified by our sensor, showing excellent vibration sensing only by a thin optical fiber. We believe such a broadband, compact and cost-effective sensor would be a promising candidate for monitoring both acoustic and mechanical vibrations.
Evaluation of Patients with Facial Palsy and Ophthalmic Sequelae: A 23-Year Retrospective Review

ABSTRACT Purpose: Facial palsy (FP) can result in serious ophthalmic sequelae including loss of vision. We describe the clinical characteristics of FP patients presenting for ophthalmologic evaluation and the timing for initiating ophthalmologic care. Methods: We performed a retrospective review of 96 consecutive FP patients presenting between 1992 and 2015 at a tertiary eye center. The main outcome measures were time interval from the diagnosis of FP and onset of ocular symptoms to the initial ophthalmologic evaluation (IOE), and the severity of exposure keratopathy and eyelid malposition on IOE. Results: The median time interval from the diagnosis of FP to the IOE was 1.6 years (interquartile range; IQR = 0.5–9.2), and from the onset of ocular symptoms to IOE was 0.8 years (IQR = 0.3–2.3). The most common ocular symptoms were dryness (47.9%; n = 46), irritation (39.6%; n = 38), and tearing (30.2%; n = 29). A total of 26.0% (n = 25) of patients were bothered by the appearance of their eyes. Only 13.5% (n = 13) noted change in vision. On IOE, 81.6% (n = 75) of patients had punctate epithelial erosions (PEE), of which 52.3% (n = 35) had moderate to severe PEE, 3.3% (n = 3) had corneal ulcers and 2.2% (n = 2) had corneal abrasions. The average margin-reflex distance 2 was 6.4 mm (SD = 2.4) with average lagophthalmos of 3.5 mm (SD = 3.1). Conclusions: Among FP patients presenting for ophthalmologic evaluation, exposure keratopathy (as evidenced by PEE and corneal ulcers/abrasions) is highly prevalent and moderately severe on IOE, despite only 13.5% of patients noting decreased vision. These findings underscore the importance of timely and thorough ophthalmologic evaluation of FP patients.
Efficient Colorization of Medical Imaging based on Colour Transfer Method

Colorization is an automatic technique to enhance greyscale images by introducing chromatic information. In this research we investigate to produce colorized medical images, potentially supporting in better understanding of anatomy, anomalies and infections. Begins with proposed mandatory preprocessing steps for medical images noise removal and edge improvement, followed by colorization process. On providing target color reference medical image, chromatic information was transferred to greyscale input image. The generated colorized medical images are excellent representation biomedical structures. Performance of the proposed technique was compared with state of art methodologies, yet evaluation parameters validate the supremacy of proposed system.
Psychobiological impact of ethnic discrimination in Turkish immigrants living in Germany

Abstract Perceived ethnic discrimination has a negative impact on health. One of the key mechanisms may be a dysregulation of stress-responsive systems. Our aims were to investigate whether (1) acute face-to-face ethnic discrimination induces a stress response, and (2) to compare long-term endocrine functioning between immigrants and nonimmigrants. 30 male Turkish immigrants living in Germany underwent an ethnic discrimination condition and a control condition in the laboratory. Perceived ethnic discrimination, stress, salivary alpha-amylase and cortisol were measured four times. Heart rate and electrodermal activity were measured continuously. In addition, hair samples were collected from immigrants and 25 male nonimmigrants to determine long-term cortisol concentrations. Immigrants showed increases in perceived ethnic discrimination, stress, heart rate, alpha-amylase and cortisol during the ethnic discrimination condition. Immigrants had significantly lower hair cortisol concentrations than nonimmigrants. These findings suggest that acute ethnic discrimination elicits a psychobiological stress response. Abnormalities in long-term endocrine functioning in ethnic minorities may set the stage for the development of stress-related illnesses. Lay summary The present study found that racial discrimination of Turkish immigrants induced both psychological and physiological stress responses in the laboratory. Immigrants showed lower hair cortisol concentrations than nonimmigrants, indicating a dysregulated biological stress system.
Estimation of tangent planes for neighborhood graph correction

Local algorithms for non-linear dimensionality reduction (1), (2), (3), (4), (5) and semi-supervised learning algorithms (6), (7) use spectral decomposition based on a nearest neighborhood graph. In the presence of shortcuts (union of two points whose distance measure along the submani- fold is actually large), the resulting embbeding will be unsatisfactory. This paper proposes an algorithm to correct wrong graph connections based on the tangent subspace of the manifold at each point. This leads to the estimation of the proper and adaptive number of neighbors for each point in the dataset. Experiments show graph construction improvement.
Teaching motion gestures via recognizer feedback

When using motion gestures, 3D movements of a mobile phone, as an input modality, one significant challenge is how to teach end users the movement parameters necessary to successfully issue a command. Is a simple video or image depicting movement of a smartphone sufficient? Or do we need three-dimensional depictions of movement on external screens to train users? In this paper, we explore mechanisms to teach end users motion gestures, examining two factors. The first factor is how to represent motion gestures: as icons that describe movement, video that depicts movement using the smartphone screen, or a Kinect-based teaching mechanism that captures and depicts the gesture on an external display in three-dimensional space. The second factor we explore is recognizer feedback, i.e. a simple representation of the proximity of a motion gesture to the desired motion gesture based on a distance metric extracted from the recognizer. We show that, by combining video with recognizer feedback, participants master motion gestures equally quickly as end users that learn using a Kinect. These results demonstrate the viability of training end users to perform motion gestures using only the smartphone display.