Miracle-dz/UniFAR-FTUs huggingface dataset:
Drosophila Melanogaster

$ 3 mm long dipteran ( ̄y), commonly known as the fruit ̄y. $ Adult ̄y is yellow-brown in colour, with oval wings and rust-red eyes. $ y180 Mb genome, as four chromosomes X/Y, 2, 3 and 4. $ Genome sequence substantially completed 24 March 2000. $ 120 Mb euchromatic region of genome comprises 13 601 predicted genes. $ Has made signi®cant contribution to understanding of development. $ Large-scale P-insertion mutagenesis (and enhancer-trap), microarray and expression pattern projects underway, proteomics project being set up. $ Comparative studies with insect relatives including grasshoppers, beetles and moths, but mainly used in comparative studies with higher eukaryotes.
MicroRNA Expression Analysis of Centenarians and Rheumatoid Arthritis Patients Reveals a Common Expression Pattern

Micro-RNA (miRNA) are a family of small non-coding ribonucleic acids that inhibits post-transcriptionally the expression of their target messenger RNA (mRNA). We are interested in studying the involvement of miRNA in longevity and autoimmune diseases. In this study we compared the different expression of seven microRNAs between human plasma healthy controls, plasma samples of centenarians and samples from patients with rheumatoid arthritis. We used the Life Technologies' protocol to quantify seven miRNAs from 62 plasma samples: 20 healthy human controls, 14 centenarians, 28 patients with rheumatoid arthritis. TaqMan MicroRNA assays were used to analyze the expression profiles of miR-125b-5p, miR-425-5p, miR-200b5p, miR-200c-3p, miR-579-3p, miR-212-3p, miR-21-5p and miR-126-3p. The relative expression of mature miRNAs was analyzed using software REST. Our results show that miR-425-5p, miR-21 and miR-212 significantly decreased in centenarians and in patients with rheumatoid arthritis compared with controls. Furthermore in this work we highlight a connection between corticosteroid treatment and miRNAs expression.
Social Achievement Goals

Little extant research attempts to understand why rural African Americans engage in social relationships with peers in school. This is somewhat surprising as rural students’ peer interactions often affect their scholastic desires, and peers can alter African Americans’ academic performance. Hence, the current study examined both the presence and psychometric validity of social achievement goals among rural African American high school students. Results suggest the presence of three reasons for engaging in social relationships in school: social development (desire to increase friendship quality), social demonstration-approach (wanting to appear “cool” among friends), and social demonstration-avoid (fear of appearing socially inferior). Confirmatory factor analysis and Rasch analysis provide support for both the presence and valid measurement of social achievement goals among rural African American adolescents.
The Validity of Composite Photographs for Assessing Masculinity Preferences

Among non-human animals, exaggerated male traits may signal immunocompetence and are often attractive to females. This finding has not been reliably replicated in human populations, however, where preferences for feminised male faces are often observed in experiments. Some authors have suggested that certain experimental approaches, and in particular the use of ‘composite’, or averaged, photographs, may lack ecological validity and elicit misleading responses. This may account for reports of preferences for femininity. To date, however, experiments have varied on numerous, often confounded, methodological dimensions, making the contribution of different factors difficult to assess. To address this, we conducted an experiment to examine the influence of stimulus type on participant responses. Masculinity preferences were measured using both composite photographs and the photographs from which they were composed, while all other methodological variables were held constant. In contrast to predictions by previous authors, composites elicited significantly stronger overall preferences for masculinity, especially when textural information was reduced during the averaging process. The existence of preferences for feminised male faces is unlikely to be explained by the use of composite photographs alone.
Association Between Substance Use Disorder and Polygenic Liability to Schizophrenia

Background There are high levels of comorbidity between schizophrenia and substance use disorder, but little is known about the genetic etiology of this comorbidity. Methods Here, we test the hypothesis that shared genetic liability contributes to the high rates of comorbidity between schizophrenia and substance use disorder. To do this, polygenic risk scores for schizophrenia derived from a large meta-analysis by the Psychiatric Genomics Consortium were computed in three substance use disorder datasets: COGEND (ascertained for nicotine dependence n=918 cases, 988 controls), COGA (ascertained for alcohol dependence n=643 cases, 384 controls), and FSCD (ascertained for cocaine dependence n=210 cases, 317 controls). Phenotypes were harmonized across the three datasets and standardized analyses were performed. Genome-wide genotypes were imputed to 1000 Genomes reference panel. Results In each individual dataset and in the mega-analysis, strong associations were observed between any substance use disorder diagnosis and the polygenic risk score for schizophrenia (mega-analysis pseudo R2 range 0.8%-3.7%, minimum p=4×10-23). Conclusions These results suggest that comorbidity between schizophrenia and substance use disorder is partially attributable to shared polygenic liability. This shared liability is most consistent with a general risk for substance use disorder rather than specific risks for individual substance use disorders and adds to increasing evidence of a blurred boundary between schizophrenia and substance use disorder.
Leadership Roles of a Pre-School Principal in the Use of Information and Communication Technology: A Hong Kong Experience

The incorporation of information and communications technology (ICT) in education is increasingly recognised as a priority for schools in Hong Kong. Teachers are now expected to undertake formal training to ensure they are proficient in the use of ICT and are able to use it effectively within the classroom setting. This colloquium highlights the important role played by school leaders in ensuring the successful transition of schools within the ‘information age’. It is argued that principals need to inspire, encourage and support teachers to meet the challenges that lie ahead. The colloquium reports on a case study of a pre-school leader's practices in the use of ICT. The study investigates the strategies the principal used to promote the use of ICT in the pre-school and her influence on ICT use in the kindergarten.
Insisting on equity: A redistribution approach to education

Emphasis on educational efficiency, or accountability, with all its claims towards institutional improvement, has left the question of educational equity unanswered. Contemporary policy, particularly in Western nations, focuses largely on raising aggregate test scores while the greater society sees a steady increase in economic inequality. It is the purpose of this article to trace the current increase in inequality through income and wealth distributions, and argue that educational equity should also be a priority for all nations. Part one of this article gives both quantitative and qualitative examples of growing economic inequalities, and posits reasons why this is detrimental to human society. Part two provides evidence that an equitable redistribution approach to education may serve as part of an answer to these problems. Part three addresses counterarguments to these assertions, and describes how education alone cannot solve the question of equity.
Global Quality Norms within National Production Regimes: ISO 9000 Standards in the French and German Car Industries

This article examines the impact of ISO 9000 upon different national production regimes. It asks how ISO 9000 has influenced the reorganization of industry, and how this reorganization has affected the production systems of different advanced industrial countries, in this case France and Germany. The paper argues that within the wider context of increased international competition within the car industry, ISO 9000 technical norms have facilitated a modernization of supplier network practices and work organization in both countries. Yet, at the same time, the implementation of ISO 9000-based quality management systems within firms and the reorganization of relationships across firms have tended to reproduce the previously existing architectures of authority and risk distribution, but within the context of modernized technical practices. In France, the quality standards reproduced, while modernizing, the underlying Taylorist company organization and the hierarchical links between final assemblers and their suppliers. In Germany, in contrast, ISO 9000 norms became embedded within new production concepts that reinforced the autonomy of skilled workers. In inter-firm relationships, they act as an informal insurance clause against new liability risks associated with network forms of organization, thus safeguarding the autonomy of small firms.
Dynamism and Enterprise

Abstract The aim of this paper is to see how Asian female entrepreneurs in the United Kingdom have developed and to increase our understanding of this entrepreneurial minority. The study looks at some of the more successful Asian women who are prominent in the United Kingdom by being featured in the top 200 Asian rich list. Both primary and secondary sources were used to profile these women. Open ended face-to-face interviews were also conducted with Asian women from second/third generations who had some business ownership stake in the more traditional low value added, labour intensive businesses. Questions centred around why they started their business, the support they received, the challenges facing them specifically as Asian women in business both at start up and beyond, their aspirations for the future of the business and their motivations. The findings show that the gap appears to have widened between the more successful Asian business woman and those women who are still opting for low value added, labour intensive firms. The practical implications of this study are that Asian women are an increasingly important part of the SME group and thus increasing the quality of business provision, advice, start up and growth would make this vital sector even more productive. This study will also help sensitise and inform business support agents, banks, advisors both public sector and private. Understanding the needs of this entrepreneurial minority is important for academic, policy makers and support professionals.
Necrostatin-1 enhances the resolution of inflammation by specifically inducing neutrophil apoptosis

Neutrophils play a central role in innate immunity and are rapidly recruited to sites of infection and injury. Neutrophil apoptosis is essential for the successful resolution of inflammation. Necrostatin-1 (Nec-1,methyl-thiohydantoin-tryptophan (MTH-Trp)), is a potent and specific inhibitor of necroptosis[1] (a newly identified type of cell death representing a form of programmed necrosis or regulated non apoptotic cell death) by inhibiting the receptor interacting protein 1(RIP1) kinase. Here we report that Nec-1 specifically induces caspase-dependent neutrophils apoptosis and overrides powerful anti-apoptosis signaling from survival factors such as GM-CSF and LPS. We showed that Nec-1 markedly enhanced the resolution of established neutrophil-dependent inflammation in LPS-induced acute lung injury in mice. We also provided evidence that Nec-1 promoted apoptosis by reducing the expression of the anti-apoptotic protein Mcl-1 and increasing the expression of pro-apoptotic protein Bax. Thus, Nec-1 is not only an inhibitor of necroptosis, but also a promoter of apoptosis, of neutrophils, enhancing the resolution of established inflammation by inducing apoptosis of inflammatory cells. Our results suggest that Nec-1 may have potential roles for the treatment of diseases with increased or persistent inflammatory responses.
File encryption using Fisher-Yates Shuffle

A permutation cipher is a very old form of cryptography. It works by moving letters around in a random pattern. In this paper we have implemented a new method of pseudorandom permutation. Along with this, a working algorithm has been provided that produces a block cipher using the mentioned procedure. The discussed algorithm operates on a file containing a stream of integers delimited by a space. The file is first converted to a two dimensional array. This array is randomly shuffled. Thereafter the encrypted cipher is obtained by recombining the keys with the shuffled array. For decryption, the cipher is again read into a two dimensional array. This time, the entire array is sub-divided into three parts. The first and the final part consist of the shuffled message. The second part consists of the keys. The elements of the shuffled array are then rearranged in accordance to the keys. The recombination results in retrieving the original file containing the stream of integers.
Adaptive bandwidth management and QoS provisioning in large scale ad hoc networks

Quality of service provisioning in wireless ad hoc networks plays an integral part in determining the success of network-centric warfare as envisioned in future military operations. It requires good scalability of the QoS architecture since ad hoc networks in the battlefield tend to be large. Previous work attacking QoS in ad hoc networks seldom considers the scalability issues. In this paper, we propose a scalable QoS architecture for such networks. Our scheme draws upon the positive aspects of both IntServ and DiffServ, and extends upon the scalable LANMAR routing protocol to support QoS. The scheme is also capable of incorporating mobile backbone networks (MBNs) to further improve the scalability. Simulation results show that our proposed QoS architecture can achieve good scalability in terms of large network size and mobility.
Influence of Moral Affect, Judgment, and Intensity on Decision Making Concerning Counterfeit, Gray-Market, and Imitation Products

We examined the direct effects of moral judgment, moral intensity, and moral affect, specifically shame and guilt, on undergraduates' purchase intent concerning counterfeits, gray-market products, and imitations. The indirect effects of moral intensity, shame, and guilt on moral judgment were also investigated. A between subjects experiment was designed and participants (n = 313) responded to a scenario. For both the counterfeit and imitation products, moral judgment had a significant negative effect on purchase intent. Moral intensity had no significant effect on purchase intent for all product types but it had significant positive influence on moral judgment for all product types. Guilt had a significant negative influence on purchase intent for gray-market products and a positive influence on moral judgment for all product types. In addition, moral judgment mediated the impact of guilt on intent to purchase gray-market products.
Does the Factor Structure of Military Sexual Stressors in Men Correspond to Women's? A Confirmatory Factor Analysis Using the Sexual Harassment Inventory.

OBJECTIVES Unwanted sexual stressors experienced by military men and women are associated with a host of negative physical and mental health problems. Government officials are making it a priority to put a stop to these unwanted sexual experiences. However, the measure typically used measures sexual stressors much better for women than for men. The purpose of the present study was to test the factor structure of an alternative measure, the Sexual Harassment Inventory (SHI), to examine whether sexual stressors experienced by men correspond to women's experiences. METHODS We used three preexisting datasets in which the SHI was used to assess active and former military members' sexual stressor experiences. We conducted an exploratory factor analysis to identify women's response patterns and a confirmatory factor analysis to determine whether men's response patterns corresponded to women's. RESULTS Findings showed that the SHI has evidence of factorial validity in female service members and adequate, but not exceptional, factorial fit for male service members. CONCLUSIONS It is imperative that more work be done to better understand how men experience and perceive potential military sexual stressors and how those perceptions and experiences compare to women's.
Assimilation in existing and novel German compounds

Place assimilation is a phonologically regular variation that modifies the surface form of words: Coronal consonants can change their place of articulation (e.g., rainbow←raimbow). These variations do not seem to disturb lexical access as long as the change is licensed by the following phonemic context (Coenen, Zwitserlood, & Bölte, 2001; Gaskell & Marslen-Wilson, 1996). This study compares the listeners’ tolerance to contextually appropriate () and inappropriate changes (bahmgleis) in existing (bahngleis; railway track) and novel German compounds (bahngeist; railway ghost). The results from two cross-modal form priming experiments reveal that listeners showed equal tolerance for contextually appropriate changes that actually occur in language and for inappropriate changes that are never produced in the context presented. This pattern held for existing and novel compounds. Our findings suggest that word form representations for possible phonemic variants of morphologically complex words are not listed in the lexicon.
An efficient algorithm for finding double-vertex dominators in circuit graphs

Graph dominators provide a general mechanism for identifying re-converging paths in circuits. This is useful in a number of CAD applications, including computation of signal probabilities for test generation, switching activities for power and noise analysis, statistical timing analysis, cut point selection in equivalence checking, etc. Single-vertex dominators are too rare in circuit graphs to handle re-converging paths in a practical way. The paper addresses the problem of finding double-vertex dominators, which occur more frequently. First, we introduce a data structure, called dominator chain, which allows the representation of all possible O(n/sup 2/) double-vertex dominators of a given vertex in O(n) space, where n is the number of vertices of the circuit graph. Dominator chains can be efficiently manipulated, e.g., it takes constant time to look-up whether a given pair of vertices is a double-vertex dominator. Second, we present an efficient algorithm for finding double-vertex dominators. The experimental results show that the presented algorithm is an order of magnitude faster than existing algorithms for finding double-vertex dominators. Thus, it is suitable for running in an incremental manner during logic synthesis.
Infant-led innovations in a mother-baby therapy group

Abstract A mother-baby therapy group for mothers and infants in their first year who are experiencing difficulties is described. In a literature review no comparable group where the infants are seen as members in their own right has been found. Themes in the mothers' material are outlined, followed by the infants' evolving interactive and internal processes. Some therapeutic factors, in particular interactions between the infants and interventions on the part of the therapists, are then illustrated with clinical material. Some infant-led innovations are described, such as the way the infants' activity is used as a basis for making ‘group as a whole’ interpretations, and in particular how the therapists' actions towards the infants have come to be viewed as a non-verbal form of interpretation. The role of attuned play in direct work with infants is discussed further.
Classification of News and Research Articles Using Text Pattern Mining

Text mining is nothing but the discovery of interesting knowledge in text documents. But there is a big challenging issue that how to guarantee the quality of discovered relevant features. And that are in the text documents for describing user preferences because of the large number of terms, patterns and noise. For text mining there are basically two types of approaches; one is term based approach and another is phrase based approach. But term based approach suffered with the problem of polysemy and synonymy. And phrase based approach suffered with low frequency occurrence. But phrase based approaches are better than the term based approaches. But pattern based approach is better than the term based and phrase based approach. The proposed method utilize pattern approach with the set of keywords, which is an innovative and effective pattern discovery technique by which research articles, news articles classification of different field are done and more than 80 percent of documents are successfully identified. Index Terms: Computer Networks, Network Security, Anomaly Detection, Intrusion Detection. I. INTRODUCTION Text Mining (1) is the discovery by computer of new, previously unknown information, by automatically extracting information from different written resources. A key element is the linking together of the extracted information together to form new facts or new hypotheses to be explored further by more conventional means of experimentation. Text mining is different from what are familiar with in web search. In search, the user is typically looking for something that is already known and has been written by someone else. The problem is pushing aside all the material that currently is not relevant to your needs in order to find the relevant information. In text mining, the goal is to discover unknown information, something that no one yet knows and so could not have yet written down. Text mining offers a solution to this problem by replacing or supplementing the human reader with automatic systems Undeterred by the text explosion. It involves analyzing a large Collection of documents to discover previously unknown Information. The information might be relationships or Patterns that are buried in the document collection and which would otherwise be extremely difficult, if not impossible, to discover. Text mining can be used to analyze natural language documents about any subject, although much of the Interest at present is coming from the biological sciences. Originally, research in text categorization addressed the binary problem,
Human and Monkey Ventral Prefrontal Fibers Use the Same Organizational Principles to Reach Their Targets: Tracing versus Tractography

This article is a comparative study of white matter projections from ventral prefrontal cortex (vPFC) between human and macaque brains. We test whether the organizational rules that vPFC connections follow in macaques are preserved in humans. These rules concern the trajectories of some of the white matter projections from vPFC and how the position of regions in the vPFC dictate the trajectories of their projections in the white matter. To address this question, we present a novel approach that combines direct tracer measurements of entire white matter trajectories in macaque monkeys with diffusion MRI tractography of both macaques and humans. The approach allows us to provide explicit validation of diffusion tractography and transfer tractography strategies across species to test the extent to which inferences from macaques can be applied to human neuroanatomy. Apart from one exception, we found a remarkable overlap between the two techniques in the macaque. Furthermore, the organizational principles followed by vPFC tracts in macaques are preserved in humans.