Miracle-dz/UniFAR-FTUs huggingface dataset:
The Temple of Zeus at Olympia, Heroes, and Athletes

The two pediments and twelve metopes adorning the Temple of Zeus at Olympia of ca. 470–456 B.C. have been the subject of scholarly inquiry since their discovery in the 19th century. These inquiries tend to treat the sculptural elements separately from each other, or largely detached from their Olympic context, and to interpret the sculptures as negative admonitions about hubris and consequent justice, or about dike and arete, or as political allegories. The present study examines the sculptures as a programmatic unity intimately connected with Olympia and the activities that occurred there and argues that, contrary to previous interpretations, the sculptures were created to serve as positive models to inspire and exhort Olympic athletes to deeds of honor and glory.
Phenotypic and genotypic profile of clinical and animal multidrug‐resistant Salmonella enterica isolates from Mexico

The objective of this study was to obtain a phenotypic and genotypic profile of Salmonella enterica including multidrug‐resistant (MDR) isolates from food‐producing animals and clinical isolates, as well as their genetic relatedness in two different States of Mexico (Jalisco and State of Mexico).
How do economic growth and social capital shape subjective well-being? Old question, new method

The work of Easterlin questioned the relationship between economic growth and life satisfaction. Subsequent research on “Easterlin paradox” provided conflicting evidence, which suggests that the paradox holds in some conditions but not in others. However, these conditions were only rarely investigated by the literature, in part because the debate has been limited by use of country-level aggregated data. Our paper fills this gap by investigating the relationship between economic growth and life satisfaction with individual-level data. Additionally, we test the hypotheses that economic growth has positive effect on subjective well-being in the presence of high social capital and low income inequality. We use large comparative data set of World Values Survey and European Values Study. Multilevel regression allows us to estimate the effect of GDP and economic growth on individual subjective well-being, controlling for its individual-level determinants. We also test if social capital and income inequality moderate this relationship. Our results show that the Easterlin paradox, stating that economic growth does not increase people’s well-being, is true only under specific conditions. In particular, in developed countries, economic growth has a positive effect on life satisfaction if it occurs in conditions of low growth of income inequality, high levels of social trust, and high growth of social capital. However, our results also show that economic growth had a predominantly negative effect on subjective well-being in developing countries. Our study is the first one to re-examine Easterlin paradox with multilevel model and to investigate the conditions under which it holds. Our results point out to the importance of socially sustainable economic growth.
Motor Preparation Disrupts Proactive Control in the Stop Signal Task

In a study of the stop signal task (SST) we employed Bayesian modeling to compute the estimated likelihood of stop signal or P(Stop) trial by trial and identified regional processes of conflict anticipation and response slowing. A higher P(Stop) is associated with prolonged go trial reaction time (goRT)—a form of sequential effect—and reflects proactive control of motor response. However, some individuals do not demonstrate a sequential effect despite similar go and stop success (SS) rates. We posited that motor preparation may disrupt proactive control more in certain individuals than others. Specifically, the time interval between trial and go signal onset—the fore-period (FP)—varies across trials and a longer FP is associated with a higher level of motor preparation and shorter goRT. Greater motor preparatory activities may disrupt proactive control. To test this hypothesis, we compared brain activations and Granger causal connectivities of 81 adults who demonstrated a sequential effect (SEQ) and 35 who did not (nSEQ). SEQ and nSEQ did not differ in regional activations to conflict anticipation, motor preparation, goRT slowing or goRT speeding. In contrast, SEQ and nSEQ demonstrated different patterns of Granger causal connectivities. P(Stop) and FP activations shared reciprocal influence in SEQ but FP activities Granger caused P(Stop) activities unidirectionally in nSEQ, and FP activities Granger caused goRT speeding activities in nSEQ but not SEQ. These findings support the hypothesis that motor preparation disrupts proactive control in nSEQ and provide direct neural evidence for interactive go and stop processes.
Performance simulation of phasor measurement unit for wide area measurement system

With the phenomenal growth of power system both in terms of geographical sprawl as well as technological advancements, it requires tools for dealing with system-wide disturbances that often cause widespread catastrophic blackouts in power system networks. When a major disturbance occurs, protection and control measures play the most important role to prevent further degradation of the system, restore the system back to a normal state, and minimize the impact of the disturbance. Continuous technological innovations in information and communication technology, novel sensors and measurement principles in general have promoted the advent of phasor measurement units (PMUs). This paper describes the modeling and testing of phasor measurement unit for two bus transmission line system using MATLAB/Simulink. Since PMUs are costly device therefore module wise testing and analysis are essential. For such modeling and testing, software based analysis is the best approach. This has been done through MATLAB and the results are analyzed.
Taxonomy on malware evasion countermeasures techniques

One of the major threats on the Internet is Malware — malicious software which intends to harm IT infrastructures and systems. In the context of Internet-of-Things (IoT), the public attention has been particularly drawn to the growing number of malware programs targeting IoT devices and related security in the recent years. Increasingly the malware, being polymorphic or metamorphic, changes behavior or remains inactive until a specific environment changes. These behaviors are the malware's detection evasion techniques to avoid detection and capture. Such highly evasive malicious programs are on the rise, resulting in extensive research efforts needed on evasion countermeasures. However, there is still a lack of a comprehensive and useful taxonomy to classify the existing countermeasures. This work fills the gap by presenting a survey on available malware evasion countermeasures from both academia and industry. Our main goal of proposing this taxonomy is, help to build a scalable classification of evasion countermeasures which will support malware analysis and classification as well as to guide the design of future evasion countermeasures.
Impacts of increased α-synuclein on clathrin-mediated endocytosis at synapses: implications for neurodegenerative diseases

α-Synuclein causes synaptic pathologies in several neurodegenerative diseases: Parkinson’s disease (PD) is a neurodegenerative disease that impacts the lives of millions of people worldwide. A pathological hallmark of PD, as well as dementia with Lewy bodies (DLB) and several Alzheimer’s disease variants, is the appearance of intracellular inclusions called Lewy bodies, which contain high levels of aggregated α-synuclein. α-Synuclein is a presynaptic protein that normally associates with synaptic vesicle membranes and regulates synaptic vesicle trafficking under physiological conditions (Calo et al., 2016). However, in familial PD, multiplication and several point mutations in the α-synuclein gene (SNCA) ultimately lead to toxic aggregation of the α-synuclein protein and subsequent degeneration of dopaminergic neurons in the substantia nigra, although other brain areas are also affected (Schulz-Schaeffer, 2010). Recent studies indicate that toxic oligomerization and aggregation of α-synuclein also occurs in presynaptic boutons concurrently with or before Lewy body formation in both experimental models and human patients. When overexpressed, α-synuclein forms synaptic aggregates, which are associated with compromised neurotransmission in PD animal models (Nemani et al., 2010). These synaptic aggregates, rather than Lewy body prevalence, are highly correlated with greater cognitive decline in PD and DLB patients (Schulz-Schaeffer, 2010; Calo et al., 2016). Therefore, synaptic aggregation of α-synuclein likely plays a central role in triggering α-synucleinopathies, making the synapse a crucial place in which to study disease pathogenesis. The classical model for α-synuclein toxicity suggests that misfolding of cytosolic monomeric α-synuclein leads to assembly of small toxic oligomers, followed by fibrillation, aggregation, and eventually Lewy body formation. In this model, the native form of α-synuclein is monomeric and possesses a random coil structure. However, recent studies challenge this model, suggesting that folded alpha-helical tetramers represent the native form of α-synuclein (Selkoe et al., 2014). By these reports, tetramers are more stable and resistant to aggregation compared to monomeric α-synuclein. Despite this debate, it is generally accepted that neurons naturally produce some monomeric, dimeric, and oligomeric forms of α-synuclein and that altering the balance of these molecular species contributes to disease pathogenesis. However, how each molecular species of α-synuclein impacts neuronal function, including synaptic function, is unknown.
Disarming a Paradox of Validity

Any theory of truth must find a way around Curry’s paradox, and there are well-known ways to do so. This paper concerns an apparently analogous paradox, about validity rather than truth, which JC Beall and Julien Murzi (“Two Flavor’s of Curry’s Paradox”) call the v-Curry. They argue that there are reasons to want a common solution to it and the standard Curry paradox, and that this rules out the solutions to the latter offered by most “naive truth theorists”. To this end they recommend a radical solution to both paradoxes, involving a substructural logic, in particular one without structural contraction. In this paper I argue that substructuralism is unnecessary. Diagnosing the “v-Curry” is complicated because of a multiplicity of readings of the principles it relies on. But these principles are not analogous to the principles of naive truth, and taken together there is no reading of them that should have much appeal to anyone who has absorbed the morals of both the ordinary Curry paradox and the Second Incompleteness Theorem.
Thio-Linked UDP–Peptide Conjugates as O-GlcNAc Transferase Inhibitors

O-GlcNAc transferase (OGT) is an essential glycosyltransferase that installs the O-GlcNAc post-translational modification on the nucleocytoplasmic proteome. We report the development of S-linked UDP–peptide conjugates as potent bisubstrate OGT inhibitors. These compounds were assembled in a modular fashion by photoinitiated thiol–ene conjugation of allyl-UDP and optimal acceptor peptides in which the acceptor serine was replaced with cysteine. The conjugate VTPVC(S-propyl-UDP)TA (Ki = 1.3 μM) inhibits the OGT activity in HeLa cell lysates. Linear fusions of this conjugate with cell penetrating peptides were explored as prototypes of cell-penetrant OGT inhibitors. A crystal structure of human OGT with the inhibitor revealed mimicry of the interactions seen in the pseudo-Michaelis complex. Furthermore, a fluorophore-tagged derivative of the inhibitor works as a high affinity probe in a fluorescence polarimetry hOGT assay.
A 174 pW–488.3 nW 1 S/s–100 kS/s All-Dynamic Resistive Temperature Sensor With Speed/Resolution/Resistance Adaptability

A versatile resistive temperature sensor for Internet-of-Things is presented, based on an all-dynamic architecture. This allows efficient scaling of power with conversion rate, enables optional oversampling for an adaptable resolution, and provides efficient adaptability to different resistor values. A new double-sided measurement mode is proposed to compensate for offset, 1/f noise and nonidealities at system level. The sensor achieves a minimum power consumption of 174 pW at 1 S/s measurement rate, which scales up to 488.3 nW at 100 kS/s. It offers a nominal rms resolution of 0.61 °C and a resolution FoM as low as 1.82 pJ<inline-formula> <tex-math notation="LaTeX">$\cdot ^\circ \text{C}^{2}$ </tex-math></inline-formula>.
Rapidly Degradable Hydroxyethyl Starch Solutions Impair Blood Coagulation After Cardiac Surgery: A Prospective Randomized Trial

BACKGROUND: There is continuing concern about the effect of hydroxyethyl starch (HES) solutions on blood coagulation. Rapidly degradable HES solutions with more favorable effects on clot strength have therefore been developed. Because the risk of bleeding is increased after cardiopulmonary bypass, we examined whether these types of HES solutions could be administered after cardiac surgery without an alteration of coagulation. METHODS: Two new rapidly degradable HES solutions were compared with human albumin in 45 patients scheduled for elective primary cardiac surgery. After admission to the cardiac surgical intensive care unit, the patients were allocated in random order to receive either 15 mL/kg of HES solution with low molecular weight and low molar substitution (either 6% HES200/0.5 or 6% HES130/0.4) or 4% human albumin solution as a short-time (70–240 min) infusion. RESULTS: Clot formation time was prolonged and maximum clot firmness was decreased in thromboelastometry tracings after infusion of both HES solutions. This impairment in thromboelastometry tracings partly recovered (using InTEM® and ExTEM® coagulation activators) at 2 h after the completion of the study infusion. Platelet contribution to maximum clot firmness remained unaffected in all of the study groups. HES did not induce fibrinolysis. No changes in thromboelastometry tracings were observed after human albumin infusion. Chest tube drainage was comparable in the study groups. CONCLUSIONS: We conclude that a short-time infusion of rapidly degradable HES solutions after cardiac surgery produces impairment in fibrin formation and clot strength in thromboelastometry tracings. In this clinical setting, human albumin does not impair hemostasis.
A tenascin-C aptamer identified by tumor cell SELEX: Systematic evolution of ligands by exponential enrichment

The targeting of molecular repertoires to complex systems rather than biochemically pure entities is an accessible approach that can identify proteins of biological interest. We have probed antigens presented by a monolayer of tumor cells for their ability to interact with a pool of aptamers. A glioblastoma-derived cell line, U251, was used as the target for systematic evolution of ligands by exponential enrichment by using a single-stranded DNA library. We isolated specifically interacting oligonucleotides, and biochemical strategies were used to identify the protein target for one of the aptamers. Here we characterize the interaction of the DNA aptamer, GBI-10, with tenascin-C, an extracellular protein found in the tumor matrix. Tenascin-C is believed to be involved in both embryogenesis and oncogenesis pathways. Systematic evolution of ligands by exponential enrichment appears to be a successful strategy for the a priori identification of targets of biological interest within complex systems.
Issues in Bidding for Contracts for Occupational Therapy Services

There is an increasing number of occupational therapists in Canada who are involved in bidding for contracts to deliver occupational therapy services. Occupational therapists working in an institutional or community-based setting may not have had the responsibility of developing a proposal or a marketing plan for bidding purposes. However, the responsibility of developing a bid to compete for a service delivery contract often rests on occupational therapists who are sole practitioners in a private practice setting. The purpose of this paper is to highlight issues in the literature such as service delivery plans, marketing strategies and costing of services that can assist the occupational therapist in the development of a contractual bid. A specific clinical example, school therapy services, has been used to illustrate how these strategies can be applied to practice. Success in contractual bids appears to be primarily influenced by cost of the service, the expertise of the service provider, ability to provide coordinated care, ease of access for clients, and inclusion of methods to measure client outcome.
Ecological speciation in anemone‐associated snapping shrimps (Alpheus armatus species complex)

Divergent natural selection driven by competition for limited resources can promote speciation, even in the presence of gene flow. Reproductive isolation is more likely to result from divergent selection when the partitioned resource is closely linked to mating. Obligate symbiosis and host fidelity (mating on or near the host) can provide this link, creating ideal conditions for speciation in the absence of physical barriers to dispersal. Symbiotic organisms often experience competition for hosts, and host fidelity ensures that divergent selection for a specific host or host habitat can lead to speciation and strengthen pre‐existing reproductive barriers. Here, we present evidence that diversification of a sympatric species complex occurred despite the potential for gene flow and that partitioning of host resources (both by species and by host habitat) has contributed to this diversification. Four species of snapping shrimps (Alpheus armatus, A. immaculatus, A. polystictus and A. roquensis) are distributed mainly sympatrically in the Caribbean, while the fifth species (A. rudolphi) is restricted to Brazil. All five species are obligate commensals of sea anemones with a high degree of fidelity and ecological specificity for host species and habitat. We analysed sequence data from 10 nuclear genes and the mitochondrial COI gene in 11–16 individuals from each of the Caribbean taxa and from the only available specimen of the Brazilian taxon. Phylogenetic analyses support morphology‐based species assignments and a well‐supported Caribbean clade. The Brazilian A. rudolphi is recovered as an outgroup to the Caribbean taxa. Isolation–migration coalescent analysis provides evidence for historical gene flow among sympatric sister species. Our data suggest that both selection for a novel host and selection for host microhabitat may have promoted diversification of this complex despite gene flow.
Effect of Melt Scan Rate on Microstructure and Macrostructure for Electron Beam Melting of Ti-6Al-4V

Microstructure and variations in porosity in Ti-6Al-4V samples built with electron beam melting (EBM) over a range of melt scan speeds, ranging from 100 mm·s-1 to 1000 mm·s-1 were examined. Microstructure was characterized by refinement of α-phase and transformation to α′-martensite. Light optical microscopy, scanning electron microscopy, and transmission electron microscopy were used to observe these phenomena, while corresponding tensile testing and associated macro and microindentation hardness measurements were used to define the microstructural variations. Relative stiffness was observed to be linearly log-log related to relative density, corresponding to ideal porosity associated with open-cellular structures.
Prisoners’ Dilemma in Duopoly (Super)games

The choice between quantity and price in order to stabilize collusion is modeled here. It is shown that this relocates the prisoners’ dilemma backwards, from the market stage to the stage where the market variable is chosen in order to sustain collusion, and where discount rates appear as the payoffs. Likewise, a prisoners’ dilemma arises also when both the market variable and the type of behavior (cooperative or non-cooperative) are simultaneously chosen.
Exploiting Fission Yeast Genetic Interaction Data to Identify Disease-Specific Drug Targets for Tuberous Sclerosis Complex

i Co-authorship statement . ii Acknowledgements . iii Table of contents . iv List of tables . vi List of figures . vii List of abbreviations . ix Chapter I: Introduction . 01 1.1 Tuberous sclerosis complex . 01 1.2 The Akt-TSC1/2-mTOR signaling pathway . 03 1.3 Fission yeast as a model system to study TSC pathology . 07 1.4 Gene buffering and genetic interactions . 09 1.5 Genetics to therapeutics: rationale for my study . 13 1.6 Hypothesis and predictions . 15 Chapter II: Materials and methods . 16 2.1 Yeast strains and culture conditions . 16 2.2 Generation of S. pombe double mutants . 21 2.3 Colony growth analysis . 21 2.4 Cell culture and reagents . 21 2.5 Genotyping the mouse embryonic fibroblasts . 22 2.6 Transfections . 24 v 2.7 RNA extraction and cDNA synthesis . 24 2.8 Cell viability assay . 26 2.9 Data analysis . 26 Chapter III: Results . 27 3.1 Validation of candidate negative interactors . 27 3.2 Additional synthetic interaction screens . 29 3.3 Identification of catalytic sites within the interactors . 33 3.4 Assaying clinically orthologous mutations in S. pombe . 39 3.5 Genotyping the mouse embryonic cell lines . 45 3.6 Conservation of negative interactions in mouse embryonic fibroblasts . 49 Chapter IV: Discussion . 53 4.1 Overview of the fission yeast genetic interactome . 53 4.2 Characterization of the validated negative interactors . 54 4.3 Applying the concept of synthetic chemical-genetic interactions . 58 4.4 Investigating disease-causing clinical mutations in S. pombe . 60 4.5 Conservation of synthetic interactions . 62 4.6 Implications, challenges and future directions . 63 Literature cited . 68 Curriculum vitae . 80
Comparative genetics of disease resistance within the solanaceae.

Genomic positions of phenotypically defined disease resistance genes (R genes) and R gene homologues were analyzed in three solanaceous crop genera, Lycopersicon (tomato), Solanum (potato), and Capsicum (pepper). R genes occurred at corresponding positions in two or more genomes more frequently than expected by chance; however, in only two cases, both involving Phytophthora spp. , did genes at corresponding positions have specificity for closely related pathogen taxa. In contrast, resistances to Globodera spp. , potato virus Y, tobacco mosaic virus, and tomato spotted wilt virus were mapped in two or more genera and did not occur in corresponding positions. Without exception, pepper homologues of the cloned R genes Sw-5, N, Pto, Prf, and I2 were found in syntenous positions in other solanaceous genomes and in some cases also mapped to additional positions near phenotypically defined solanaceous R genes. This detailed analysis and synthesis of all available data for solanaceous R genes suggests a working hypothesis regarding the evolution of R genes. Specifically, while the taxonomic specificity of host R genes may be evolving rapidly, general functions of R alleles (e.g., initiation of resistance response) may be conserved at homologous loci in related plant genera.
A surface-mountable membrane supported filter

A silicon micro-machined filter with a simple planar integration on an other substrate is proposed in this article. The excitation is made from the top of the shielding substrate of a membrane supported micro-machined filter. Packaging and inter-connection are included in the design. Experimental results are presented on a two pole 30 GHz, 4% fractional bandwidth filter with a quality factor of 602 and insertion loss of 1.8 dB. Such a filter can be easily integrated in any circuit using flip-chip technology.