Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Celecoxib, a Novel Cyclooxygenase‐2 Inhibitor, on Platelet Function in Healthy Adults: A Randomized, Controlled Trial

Conventional nonsteroidal anti‐inflammatory drugs (NSAIDs) nonspecifically inhibit cyclooxygenase‐1 (COX‐1), an enzyme critical to normal platelet function, and COX‐2, which mediates inflammatory response mechanisms. Celecoxib, an antiarthritic agent that inhibits COX‐2 but spares COX‐1 at therapeutic doses, is expected to have minimal effects on platelet function. A double‐blind, randomized, placebo‐controlled study of 10 days' duration was conducted in 24 healthy adults to compare the effects on platelet function of a supratherapeutic dose of celecoxib (600 mg bid) with a standard dose of naproxen (500 mg bid), a conventional NSAID. Ex vivo platelet aggregation in response to standard agonists (collagen, arachidonate, or U46619 [a thromboxane A2 receptor agonist]), bleeding time, and serum thromboxane B2 (TxB2 level were measured. Unlike celecoxib or placebo, naproxen produced statistically significant reductions in platelet aggregation and serum TxB2 levels and increased bleeding time. The results indicate that even at supratherapeutic doses, celecoxib will not interfere with normal mechanisms of platelet aggregation and hemostasis, supporting the premise that celecoxib is COX‐1 sparing relative to conventional NSAIDs.
Child-initiated learning, the outdoor environment and the ‘underachieving’ child

The Foundation Phase for Wales advocates an experiential, play-based approach to learning for children aged three to seven years that includes child-initiated activity within the outdoor environment. In previous research, Foundation Phase practitioners maintained that children perceived to be ‘underachieving’ within the classroom came into their own when engaged in child-initiated learning outdoors. This study, which involved eight Foundation Phase teachers, aimed to explore these perceived differences as well as teachers’ perceptions of ‘underachievement’. It is concluded that the more natural outdoor spaces in which child-initiated activity took place appeared to amplify the effects of child-initiated learning and diminish the perception of underachievement; that engagement in this project enabled some teachers to see ‘underachievement’ as being distributed across people, place and activity; and that through constructing the outdoor ‘space’ as a ‘place’ embedded with positive meanings, children may have had the opportunity to reconstruct themselves as strong, competent children rather than as ‘underachieving’ pupils.
The Edinburgh/LMU Hierarchical Machine Translation System for WMT 2016

This paper describes the hierarchical phrase-based machine translation system built jointly by the University of Edinburgh and the University of Munich (LMU) for the shared translation task at the ACL 2016 First Conference on Machine Translation (WMT16). The WMT16 Edinburgh/LMU system was trained for translation of news domain texts from English into Romanian. We participated in the shared task for machine translation of news under “constrained” conditions, i.e. using the provided training data only.
A silent voice across the MEdiaverse: The Next Day as identities prosumed

I’d like to make it clear that I am a David Bowie addict. Not in recovery, not in denial, but an addict through and through. I can’t ignore him. I have to obtain everything he does, in every format available. I have to find a way to like everything he produces. I make no apologies. Quite simply, David Bowie is a hugely important part of my own biography (Stevenson 2006, p. 3). An aspect of this obsession is the constant search for Bowie news. Like so many Bowie obsessives, I was stunned by his unexpected return in March 2013. After a 10-year hiatus, the promise of new music may have excited me, but what really interested me was the self-imposed media silence that defined the nature of this return. Bowie’s work has, since the success of Ziggy Stardust, been accompanied by an unmistakable and brilliantly loud concept. Whether the death of Ziggy or the birth of the Thin White Duke, the stock-market bondsman or the new-media alchemist, Bowie’s each and every move has been channelled through a look, a style, a quote, an image, a sound, a geography, a character . a noise. The noise that surrounded The Next Day, however, didn’t come from Bowie himself. Only his producer Tony Visconti spoke publicly about the new music. The David Bowie website (www.davidbowie.com) was redesigned to remove pages through which Bowie himself occasionally communicated, thus underlining the notion that Bowie was the subject of the community’s gaze and not a part of the participating community. The site instead focused on news, artist biography and fan communities. The newly launched fan-organised Facebook and Twitter pages largely celebrated Bowie’s past through the regularly shared YouTube clips, classic photos and general fan ephemera. His histories became the focus of ‘David Bowie is . ’, a V&A exhibition. However, Bowie, one of art’s great communicators, said nothing. He seemed absent from the discourse that surrounded his comeback. Indeed, increasingly those closest to him talked of the man they know as David Jones. David Bowie, we’re increasingly reminded, is actually a performance. Although the entire project appears to challenge Bowie-the-mythmaker (Stevenson 2006, Trynka 2012), the myths addressed by The Next Day aren’t just the numerous versions of Bowie, but also the romantic illusion that all information is free, or in the process of inevitably becoming freed. We expect the ‘intercommunicative self’ (Marshall 2010) of our celebrities to become a noise variant in our streamed media experience. The next
A three-year comparative longitudinal study of a school-based social work family service to reduce truancy, delinquency and school exclusions

A three-year longitudinal school-based family social work service in two project schools was compared with the 'standard' service of two comparative schools, in respect to truancy, delinquency, school-exclusions, family functioning and school morale. A multi-method evaluation demonstrated significantly better outcomes in the project schools, halving truancy; reducing delinquency, improving teachers'morale and pupils'educational achievements. A cautious cost-benefit analysis identified a 250 per cent 'saving' above the cost of the project.
Validação da versão brasileira da escala de religiosidade de Duke (DUREL)

BACKGROUND: There is a shortage of validated instruments for the study of religiousness in Brazilian samples. A recent study in a community sample pointed to an adequate validity for the Brazilian Portuguese version of the Duke Religiosity Index (P-DUREL). Nevertheless, no study to date has investigated the psychometric properties of the P-DUREL in psychiatric and/or university student samples. OBJECTIVE: To determine the internal consistency, the test-retest reliability and the convergent-discriminant validity of the P-DUREL in two distinct samples. METHODS: Sample 1: university students (n = 323). Sample 2: psychiatric patients (n = 102). The P-DUREL and the World Health Organization's Quality of Life Instrument-Spirituality, Religion and Personal Beliefs module (WHOQOL-SRPB); psychological distress symptoms were measured by means the Beck Depression Inventory (BDI) and the Beck Anxiety Inventory (BAI) in sample 1, and the Hospital Anxiety and Depression Scale (HADS) in sample 2. RESULTS: The P-DUREL had adequate internal consistency (Cronbach's α > 0.80) and test-retest reliability (Intraclass Correlation Coefficient > 0.90) in both samples. Moderate correlations (0.58 < r < 0.71) between the P-DUREL subscales were observed. Furthermore, significant correlations between the P-DUREL scores with the general WHOQOL-SRPB scores as well as with psychological distress symptoms measures were observed in both samples. DISCUSSION: The present study opens perspective for the use of P-DUREL for the investigation of religiousness dimensions in Brazilian samples with diverse socio-demographic backgrounds.
Experimental demonstration of painting arbitrary and dynamic potentials for Bose–Einstein condensates

There is a pressing need for robust and straightforward methods to create potentials for trapping Bose–Einstein condensates (BECs) that are simultaneously dynamic, fully arbitrary and sufficiently stable to not heat the ultracold gas. We show here how to accomplish these goals, using a rapidly moving laser beam that ‘paints’ a time-averaged optical dipole potential in which we create BECs in a variety of geometries, including toroids, ring lattices and square lattices. Matter wave interference patterns confirm that the trapped gas is a condensate. As a simple illustration of dynamics, we show that the technique can transform a toroidal condensate into a ring lattice and back into a toroid. The technique is general and should work with any sufficiently polarizable low-energy particles.
Matrix string theory, contact terms, and superstring field theory

In this note, we first explain the equivalence between the interaction Hamiltonian of Green-Schwarz light-cone gauge superstring field theory and the twist field formalism known from matrix string theory. We analyze the role of the large N limit in matrix string theory, in particular in relation with conformal perturbation theory around the orbifold SCFT that reproduces light-cone string perturbation theory. We show how the scaling with N is directly related to measures on the moduli space of Riemann surfaces. The scaling dimension 3 of the Mandelstam vertex as reproduced by the twist field interaction is in this way related to the dimension 3(h-1) of the moduli space. We analyze the structure and scaling of the higher order twist fields that represent the contact terms. We find one relevant twist field at each order. More generally, the structure of string field theory seems more transparent in the twist field formalism. Finally we also investigate the modifications necessary to describe the pp-wave backgrounds in the light-cone gauge and we interpret a diagram from the BMN limit as a stringy diagram involving the contact term.
Human Antibody Responses to Avian Influenza A(H7N9) Virus, 2013

Understanding host antibody response is crucial for predicting disease severity and for vaccine development. We investigated antibody responses against influenza A(H7N9) virus in 48 serum samples from 21 patients, including paired samples from 15 patients. IgG against subtype H7 and neutralizing antibodies (NAbs) were not detected in acute-phase samples, but ELISA geometric mean titers increased in convalescent-phase samples; NAb titers were 20–80 (geometric mean titer 40). Avidity to IgG against subtype H7 was significantly lower than that against H1 and H3. IgG against H3 was boosted after infection with influenza A(H7N9) virus, and its level in acute-phase samples correlated with that against H7 in convalescent-phase samples. A correlation was also found between hemagglutinin inhibition and NAb titers and between hemagglutinin inhibition and IgG titers against H7. Because of the relatively weak protective antibody response to influenza A(H7N9), multiple vaccinations might be needed to achieve protective immunity.
Survey of Object-Oriented Defect Detection Approaches and Experiences in Industry

Software inspections are widely accepted as an effective technique in the battle against defects. However, most of the evidence for this is based on studies using procedural code. To investigate the use of inspections with Object-Oriented code, it is important to firstly gain the opinions of those in the front line of software development software engineers in industry and find out what the real issues are concerning Object-Oriented code inspections. This paper summarises the results of an industrial survey investigating current defect detection approaches and experiences relating to Object-Oriented code.
Phosphatidylinositol 4,5-bisphosphate Directs Spermatid Cell Polarity and Exocyst Localization in Drosophila

This study identifies phosphoinositides as key regulators of spermatid cell polarity. Polarization and elongation of spermatids in Drosophila are regulated through local synthesis of PIP2 by Sktl, which drives polarized localization of the exocyst complex to promote targeted membrane delivery and polarization of the elongating spermatid cysts.
Towards distributed coverage of complex spatiotemporal profiles

Inspired by self-organization in natural organisms, an approach that would enable robotic agents form a visual representation of an invisible distributed hazardous substance is presented. Such a resource would enable humans observe and stay away from areas of high hazardous substance concentration. In this work, a proportional-integral control law and a machine learning scheme is used to obtain optimal parameter values that would enable optimal visual mapping whilst keeping computational resources low.
Importance of Suitable Reference Gene Selection for Quantitative RT-PCR during ATDC5 Cells Chondrocyte Differentiation

Real-time quantitative reverse transcription-polymerase chain reaction (qPCR) is an efficient and accurate method to detect and compare patterns of gene expression. The reliability of qPCR is highly dependent on the selection of appropriate reference genes used for normalization. By analyzing 16 potential candidates of reference genes (GAPDH, Actb, 18 s, PGK1, Hprt, Tbp, Rpl5, B2M, Gusb, Ppia, UBC, Sdha, Eef1a1, H2afz, Tkt and Ldha) through geNorm, we identified Ppia, Tbp, Hprt and Eef1a1 as the most stable reference genes while UBC, B2M, Gusb as the least stable ones during the chondrocyte differentiation of ATDC5 cells. Considering the low expression of Eef1a1 and Tbp would cause divergent results for they failed to provide accurate normalization for RNA extraction and reverse transcription efficiency, we recommended the use of Ppia and Hprt as the most suitable genes to normalize qPCR. In addition, although GAPDH, Actb and 18 s were usually adopted in most of studies using ATDC5 cells, they were found unstable and then were not ideal reference genes for qPCR assay in ATDC5 cells chondrocyte differentiation. Also, we further confirmed that the Ppia and Hprt worked well during chondrocyte differentiation of mouse mesenchymal cells.
Representations of Canada’s role in the War on Terror: the fantasized nationalist narrative

This multi-method study is based on data collected from 99 written narratives, four in-depth semi-structured interviews, and demographic questionnaires. It depicts a particular framework in which a diverse group of university students represent Canada’s role in the War on Terror. The study reveals how these representations assist in the imagining of Canada as a peacekeeper and peace-loving nation. These presumably benign representations of the war and peace produce banal nationalism, and have implications for both students’ imagination about war and peace and for peace educators. This contributes to the importance of critical peace pedagogy in teaching students the relationships of banal nationalism, wars and peace.
Familial resemblance and shared latent familial variance in recurrent fall risk in older women.

BACKGROUND A possible familial component to fracture risk may be mediated through a genetic liability to fall recurrently. METHODS Our analysis sample included 186 female sibling-ships (n=401) of mean age 71.9 yr (SD=5.0). Using variance component models, we estimated residual upper-limit heritabilities in fall-risk mobility phenotypes (e.g., chair-stand time, rapid step-ups, and usual-paced walking speed) and in recurrent falls. We also estimated familial and environmental (unmeasured) correlations between pairs of fall-risk mobility phenotypes. All models were adjusted for age, height, body mass index, and medical and environmental factors. RESULTS Residual upper-limit heritabilities were all moderate (P<0.05), ranging from 0.27 for usual-paced walking speed to 0.58 for recurrent falls. A strong familial correlation between usual-paced walking speed and rapid step-ups of 0.65 (P<0.01) was identified. Familial correlations between usual-paced walking speed and chair-stand time (-0.02) and between chair-stand time and rapid step-ups (-0.27) were both nonsignificant (P>0.05). Environmental correlations ranged from 0.35 to 0.58 (absolute values), P<0.05 for all. CONCLUSIONS There exists moderate familial resemblance in fall-risk mobility phenotypes and recurrent falls among older female siblings, which we expect is primarily genetic given that adult siblings live separate lives. All fall-risk mobility phenotypes may be coinfluenced at least to a small degree by shared latent familial or environmental factors; however, up to approximately one-half of the covariation between usual-paced walking speed and rapid step-ups may be due to a common set of genes.
Exploitation of different types of locality for Web caches

Object access distribution in the Web is governed by Zipf's law, in general. This property leads to effective Web caches, which store the most popular objects and typically employ the LFU replacement policy, which achieves high, and often the highest, cache hit rates. However, Web cache design based only on Zipf's law has two main disadvantages: (i) it does not exploit the temporal and spatial locality of user accesses on a per session basis, and (ii) LFU implementation is costly and impractical in many environments, because it requires statistics on all objects accessed since the beginning of a cache's operation. We consider all parameters of locality of references in the Web (temporal, spatial and popularity) and draw an analogy with processor caches. Given cache replacement policies that address different locality characteristics, we argue that there exist replacement algorithms that combine these characteristics and achieve high performance at a low cost. We describe the Window-LFU (W-LFU), a policy that combines LFU and LRU and achieves better performance than LFU at lower cost. W-LFU exploits both Zipf's law, and temporal locality by using the accesses in a recent time-window. Simulations with actual traces indicate that W-LFU provides better results than theoretically expected.
Heterogeneous Behaviors and Direct Interactions in Artificial Stock Markets

In this paper, we explore the dynamic of stock prices over time by developing an agent-based market. The developed artificial market is comprised of heterogeneous agents occupied with various behaviors and trading strategies. The developed market has property of direct interaction. The environment takes the form of network structure namely, it manifests as a scale-free network. The information will flow between the agents through the linkages that connect them. The model is subjected to testing for goodness of fit to the empirical observations of the S&P500. Furthermore, the effect of increasing the population size of various agent types is investigated.
Student Self-Motivation: Lessons Learned from Teaching First Year Computing

This paper describes a study that profiled student participation in a CS1 course to identify key performance indicators and improve student learning experiences. Existing research has provided many novel teaching strategies while other research has produced findings that argue for stronger links between learning outcomes and teaching and assessment. Prior research generally used surveys as the principal mechanism for metric gathering. The study reported here used a survey instrument but additionally monitored lecture and tutorial attendance, web site access and email traffic as well as employing demographic data to examine students' learning experiences. The learning experience was improved by enhancing the student/teacher interaction in both the lectures and tutorials, mapping learning outcomes to both assessment and teaching and decoupling assessment from feedback. The results suggest that the major factor in determining whether a student passed or failed was self-motivation and willingness to engage in the range of learning activities provided for them
International Journal of Information and Communication Technology Research Evaluating Factors Affecting Broadband Intensity in Kenya

The term " broadband intensity " emerged nearly a decade ago from the Organisation for Economic Cooperation and Development (OECD) as one the domains for the assessment of broadband markets. The other two domains were broadband " adoption " and " impact " , respectively. OECD then defined broadband intensity to include the " nature, value and volume of broadband transactions ". Over the years, there have been a number of both macro and micro level studies on broadband adoption and the economic benefits associated with broadband. However, not much study has been undertaken in the area of broadband intensity. In the recent past, the emergence of mobile broadband and the associated value added services (VAS) and applications (Apps) has rekindled interest in the subject area of broadband intensity. This study 3 investigates factors affecting broadband intensity in a developing country context, in this instance Kenya. In view of the increasing access to broadband via mobile and nomadic devices in developing countries, access to and use of mobile broadband is included in the investigation to determine the demographic and control factors affecting broadband intensity in Kenya. The data on these variables was collected using a self-administered questionnaire approach. Data was tested for non-response bias and regression analysis conducted to test the role of the variables in influencing broadband intensity. The findings of this research suggest that age, level of education, income, awareness of mobile broadband, and mobile broadband use are key influencers of broadband intensity in Kenya. The paper proceeds to outline the research methodology, findings and recommendations. 3 This study is a product of ongoing Ph. D research work entitled " A framework for broadband metrics for developing countries " , funded by the
Global asymptotic adaptive tracking of robot manipulators without velocity measurements

This paper revisits the global asymptotic tracking of robot manipulators with position measurements only. A desired compensation adaptive law plus a saturated feedback term coupled to a new dynamic nonlinear filter is designed to produce global asymptotic tracking while compensating for parametric uncertainty and requiring link position measurements only. A new Lyapunov-based stability argument is utilized to prove the global asymptotic tracking. Simulations are included to illustrate the effectiveness of the proposed approach.
The stromal cell‐derived factor‐1α dependent migration of human cord blood CD34+ haematopoietic stem and progenitor cells switches from protein kinase C (PKC)‐α dependence to PKC‐α independence upon prolonged culture in the presence of Flt3‐ligand and interleukin‐6

Addition of the inflammatory cytokine interleukin (IL)‐6 to the culture medium of human cord blood haematopoietic stem and progenitor cells (HSPCs) has been shown to lead to an altered stromal cell‐derived factor‐1α‐dependent migratory phenotype. This study investigated whether this effect was attributed to a differential engagement of protein kinase C (PKC) isotypes. The migratory activity of both Flt3‐ligand and Flt3‐ligand/IL‐6 cultured cord blood HSPCs was PKC‐α dependent on day 1, but PKC‐α independent after 5 d of cultivation. PKC‐α expression was not down‐regulated in cells cultured for 5 d indicating a switch of signalling molecules directing cell migration.