Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental characterization of channel-based key establishment using reconfigurable antennas

Generation of secret encryption keys from the reciprocal electromagnetic channel represents an emerging topic within the broad field of propagation channel research. This paper uses multi-antenna channel measurements to assess the potential performance of such techniques, with the emphasis on using a reconfigurable antenna element controlled by the channel sounder to create time-variation in the wireless channel that enables establishment of long encryption keys. The results demonstrate that reconfigurable antennas can significantly enhance the security, even when the eavesdropper antennas are adjacent to or surround one of the legitimate nodes.
High blood glucose and osmolality, but not high urinary glucose and osmolality, affect neuronal nitric oxide synthase expression in diabetic rat kidney.

We recently demonstrated that neuronal nitric oxide synthase (nNOS) messenger RNA (mRNA) is markedly increased in the kidneys of diabetic rats and water-deprived rats. It can be inferred that high plasma glucose and osmolality and high renal tubular glucose and osmolality are somehow involving in renal NOS synthesis in diabetic rats. Phlorizin, a competitive inhibitor of glucose transport in the proximal tubule, causes renal glycosuria in nondiabetic rats and reverses hyperglycemia in diabetic rats. To further investigate whether high plasma glucose and osmolality or high renal tubular glucose and osmolality influence renal NOS synthesis in diabetic rats, we measured nNOS mRNA levels in phlorizin-treated normal and diabetic rats. Neuronal NOS mRNA expression in the kidneys was not significantly different between normal rats and phlorizin-treated normal rats with high urinary glucose and osmolality. The phlorizin-treated diabetic rats showed a significant decrease in the ratio of nNOS to beta-actin mRNA compared with diabetic rats. On linear-regression analysis, plasma glucose was strongly positively correlated with nNOS mRNA expression in the cortex, outer medulla, and inner medulla (r(2) =. 378, r(2) =. 680, and r(2) =. 445, respectively) of rat kidneys. Neither urine glucose concentration nor urine osmolality was correlated with nNOS mRNA expression in rat kidneys. In conclusion, our results indicate that nNOS mRNA expression in the kidneys of diabetic rats is directly affected by high blood glucose/osmolality but not by high urinary glucose or osmolality.
Automated infusion of vasoactive and inotropic drugs to control arterial and pulmonary pressures during cardiac surgery.

OBJECTIVE To evaluate the feasibility of a closed-loop system for simultaneous control of systemic arterial and pulmonary artery blood pressures during cardiac surgery. DESIGN Feasibility study. SETTING The cardiac surgery operating room. PATIENTS The performance of the multiple-drug closed-loop system was evaluated during cardiac surgery in 30 patients who required treatment with more than one vasoactive or inotropic drug. INTERVENTIONS A multiple-drug closed-loop system integrated five single-drug blood pressure controllers. Arterial hypertension was controlled using sodium nitroprusside or nitroglycerin, arterial hypotension was controlled using noradrenaline or dobutamine, and pulmonary hypertension was controlled using nitroglycerin. The anesthesiologist selected target pressures and single-drug blood pressure controllers. The multiple-drug closed-loop system had a set of priority rules that automatically activated from the selected single-drug controllers the optimum single-drug controller for each hemodynamic state. Drug infusion rates of the nonactive controllers were kept constant. The initial knowledge that was used to construct the priority rules was obtained from standard anesthetic protocols on perioperative management of cardiac surgical patients. A supervisory computer program defined the actions to be taken in cases of infusion pump problems, invalid pressure measurements, and during unexpected increases and decreases in systemic arterial pressure. MEASUREMENTS AND MAIN RESULTS The activation of single-drug controllers by the priority rules was accurate and fast. On average, a different single-drug controller was activated once every 7.2 mins. As a measure of variability, the average deviation of mean arterial pressure and mean pulmonary artery pressure from their target values was evaluated and was 8.6+/-4.0 and 4.4+/-4.0 mm Hg, respectively, before cardiopulmonary bypass and 8.0+/-3.6 and 2.4+/-0.9 mm Hg, respectively, after cardiopulmonary bypass. None of the single-drug controllers showed any signs of unstable response. CONCLUSION Closed-loop control of both arterial and pulmonary pressures using multiple drugs is feasible during cardiac surgery.
Research on applying Slopeone collaborative filtering algorithms to building products selection

The building products' types are too many to select. Nowadays, there are lots of internet-based service platforms about construction products. Selecting construction products through internet is facing with the same problem. Collaborative filtering is a frequently-used algorithm in recommend system. SlopeOne algorithm is one of collaborative filtering algorithm that uses linear regression to filter message and can recommend products in real time. This paper proposes an algorithm applying SlopeOne collaborative filtering algorithm to building products selection, which implements real-time personalized recommendation by analyzing the history data.
Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750—an antisense oligonucleotide against eIF4E—in combination with irinotecan in solid tumors and irinotecan‐refractory colorectal cancer

The eukaryotic translation initiation factor 4E (eIF4E) is a potent oncogene that is found to be dysregulated in 30% of human cancer, including colorectal carcinogenesis (CRC). ISIS 183750 is a second‐generation antisense oligonucleotide (ASO) designed to inhibit the production of the eIF4E protein. In preclinical studies we found that EIF4e ASOs reduced expression of EIF4e mRNA and inhibited proliferation of colorectal carcinoma cells. An additive antiproliferative effect was observed in combination with irinotecan. We then performed a clinical trial evaluating this combination in patients with refractory cancer. No dose‐limiting toxicities were seen but based on pharmacokinetic data and tolerability the dose of irinotecan was reduced to 160 mg/m2 biweekly. Efficacy was evaluated in 15 patients with irinotecan‐refractory colorectal cancer. The median time of disease control was 22.1 weeks. After ISIS 183750 treatment, peripheral blood levels of eIF4E mRNA were decreased in 13 of 19 patients. Matched pre‐ and posttreatment tumor biopsies showed decreased eIF4E mRNA levels in five of nine patients. In tumor tissue, the intracellular and stromal presence of ISIS 183750 was detected by IHC in all biopsied patients. Although there were no objective responses stable disease was seen in seven of 15 (47%) patients who were progressing before study entry, six of whom were stable at the time of the week 16 CT scan. We were also able to confirm through mandatory pre‐ and posttherapy tumor biopsies penetration of the ASO into the site of metastasis.
Investigation of the Near-Carrier Noise for Strain-Driven ME Laminates by Using Cross-Correlation Techniques

The near-carrier noise around the longitudinal mechanical resonance of a magnetoelectric laminated composite has been investigated. By simultaneously applying a high-frequency electric field across the piezoelectric phase, the sensor response to low-frequency magnetic signals can be shifted around the “carrier” frequency as side band modulation signals. This magnetoelectric response can appear either as an electric charge via piezoelectric-to-piezoelectric (PP) modulation effects or as a magnetic signal via piezoelectric-to-magnetic (PM) modulation effects. These two signals are detected either with a charge preamplifier or with a coil surrounding the sample and the low-frequency sensor response to the applied magnetic field can be recovered by using two independent synchronous detectors. We have designed an experimental setup to observe the direct (passive) low-frequency noise and the noise corresponding to the two above modulations. Noise cross-correlating measurements were also carried out to investigate the origin of the near-carrier noise. No noise coherence was found between the direct low-frequency noise and the noise resulting from either the PP or the PM modulations. However, a noise coherence factor of more than 50% has been found between the signals recovered from the two modulation techniques. A simple model has been used to explain this effect. The magnetoelectric sensor is considered as a nonlinear forced vibration system. Noise sources passing through such a system can be amplified and distributed around the carriers as side band noise where it hampers the equivalent magnetic noise performance. Electronic-thermal noise caused by dielectric dissipations in the piezoelectric phase can be considered as a noise source with a negligible contribution to the total noise floor. Mechanical-thermal low-frequency excess noise is found to be the only intrinsic noise source which is filtered by the nonlinear ME system and is present as an output near-carrier noise which dominates the noise level after the demodulation processes.
Detection of liver metastases from endocrine tumors: a prospective comparison of somatostatin receptor scintigraphy, computed tomography, and magnetic resonance imaging.

PURPOSE To compare the respective sensitivity of somatostatin receptor scintigraphy (SRS), computed tomography (CT), and magnetic resonance imaging (MRI) in the detection of liver metastases from well-differentiated gastroenteropancreatic endocrine tumor (WDGEP ET) patients. To define predictive factors for "high-sensitivity SRS. " PATIENTS AND METHODS Sixty-four patients with WDGEP ET underwent SRS with abdominal single-photon emission computed tomography (SPECT), spiral CT, and 1.5-T MRI within a 15-day interval, the order of which was randomized. Two readers analyzed images of each modality, blindly and independently. RESULTS Hepatic metastases were present in 40 of the 64 patients and confirmed by pathology after liver biopsy or surgery in 32 and eight patients, respectively. SRS, CT, and MRI detected a total of 204, 325, and 394 metastases, respectively. The number of detected metastases was significantly higher with MRI than with CT (P = .02) and SRS (P < 10(-4)) and higher with CT than with SRS (P < 10(-4)). SRS was negative in seven patients with a positive CT and/or MRI. More lesions were detected in 10 patients by SPECT compared with static views. The median metastasis size was significantly correlated (P = .04) with the sensitivity of SRS. CONCLUSION MRI seems to have an edge over CT and SRS for the detection of liver metastases from endocrine tumors. We recommend the systematic performance of liver MRI at WDGEP ET initial staging and before major therapeutic events. The low performance of SRS was mainly explained by the impact of the metastasis size on the detection capacity of SRS.
The clinical significance of circulating tumour cells in breast cancer and colorectal cancer patients.

BACKGROUND Circulating tumour cells (CTC) in the blood of cancer patients indicate disease progression. Their presence reflects a relapse or metastasising process since CTC survive only a short time in the circulation. MATERIALS AND METHODS Test systems developed by AdnaGen have been used for the sensitive and specific analysis of CTC. RESULTS Case reports of 2 breast cancer patients demonstrate the successful detection of CTC for therapy monitoring purposes. The disappearance of CTC reflects therapy success. The patient that responded towards therapy was characterized by the disappearance of CTC from the first therapeutic unit (TU) onwards. In contrast, CTC remained detectable in the other patient during the whole therapy pointing to only limited therapeutic efficacy and a progressive disease. Furthermore, systematic changes in the expression profile of CTC in colorectal patients at different stages of disease could be observed. Whereas EGFR was expressed in 90% of the patients with CTC during primary disease the expression level decreased to 15% in CTC of metastatic patients. On the other hand the expression of CEA was low in CTC found after primary surgery (15%) and dominant in CTC of metastatic patients (80%). CONCLUSION The analysis of CTC is a useful tool for therapy monitoring of breast cancer and colorectal cancer patients in the adjuvant and palliative situation. The molecular profiling of CTC may be used to identify therapeutic targets such as HER2 or EGFR for personalised treatment that is likely to have an important impact on the therapeutic efficacy of drugs like Herceptin or Erbitux.
A thermal emission spectral library of rock-forming minerals

A library of thermal infrared spectra of silicate, carbonate, sulfate, phosphate, halide, and oxide minerals has been prepared for comparison to spectra obtained from planetary and Earth-orbiting spacecraft, airborne instruments, and laboratory measurements. The emphasis in developing this library has been to obtain pure samples of specific minerals. All samples were hand processed and analyzed for composition and purity. The majority are 710 -1000 mm particle size fractions, chosen to minimize particle size effects. Spectral acquisition follows a method described previously, and emissivity is determined to within 2% in most cases. Each mineral spectrum is accompanied by descriptive information in database form including compositional information, sample quality, and a comments field to describe special circumstances and unique conditions. More than 150 samples were selected to include the common rock-forming minerals with an emphasis on igneous and sedimentary minerals. This library is available in digital form and will be expanded as new, well-characterized samples are acquired.
Locoregional Recurrence by Tumor Biology in Breast Cancer Patients after Preoperative Chemotherapy and Breast Conservation Treatment

Purpose The purpose of this study is to determine whether breast cancer subtype can affect locoregional recurrence (LRR) and ipsilateral breast tumor recurrence (IBTR) after neoadjuvant chemotherapy (NAC) and breast-conserving therapy (BCT). Materials and Methods We evaluated 335 consecutive patients with clinical stage II-III breast cancer who received NAC plus BCT from 2002 to 2009. Patients were classified according to six molecular subtypes: luminal A (hormone receptor [HR]+/HER2–/Ki-67 < 15%, n=113), luminal B1 (HR+/HER2–/Ki-67 ≥ 15%, n=33), luminal B2 (HR+/HER2+, n=83), HER2 with trastuzumab (HER2[T+]) (HR–/HER2+/use of trastuzumab, n=14), HER2 without trastuzumab (HER2[T–]) (HR–/HER2+, n=31), and triple negative (TN) (HR–/HER2–, n=61). Results After a median follow-up period of 7.2 years, 26 IBTRs and 37 LRRs occurred. The 5-year LRR-free survival rates were luminal A, 96.4%; B1, 93.9%; B2, 90.3%; HER2(T+), 92.9%; HER2(T–), 78.3%; and TN, 79.6%. The 5-year IBTR-free survival rates were luminal A, 97.2%; B1, 93.9%; B2, 92.8%; HER2(T+), 92.9%; HER2(T–), 89.1%; and TN, 84.6%. In multivariate analysis, HER2(T–) (IBTR: hazard ratio, 4.2; p=0.04 and LRR: hazard ratio, 7.6; p < 0.01) and TN subtypes (IBTR: hazard ratio, 6.9; p=0.01 and LRR: hazard ratio, 8.1; p < 0.01) were associated with higher IBTR and LRR rates. A pathologic complete response (pCR) was found to show correlation with better LRR and a tendency toward improved IBTR controls in TN patients (IBTR, p=0.07; LRR, p=0.03). Conclusion The TN and HER2(T–) subtypes predict higher rates of IBTR and LRR after NAC and BCT. A pCR is predictive of improved IBTR or LRR in TN subtype.
Epidemiology of Epilepsy in India

Summary: The article briefly reviews literature pertinent to the incidence, prevalence, prognosis, etiology, and treatment gap of epilepsy in India. Despite defective methodology, Indian studies have shown prevalence rates comparable with those from other countries. No incidence studies exist. Prognosis for those with epilepsy is worse in developing countries. The role of infection, especially neurocysticercosis, in the etiology of epilepsy has still to be fully worked out, as must the relative contributions of the other known etiological factors. Neuroimaging is needed to calculate attributable risk. Reasons for the treatment gap are discussed briefly, pointing out that in India, people seek alternative forms of treatment concurrently. The occurrence and effects of stigma are mentioned. The article ends with the author's opinion on how and where the epidemiology of epilepsy should proceed in the future.
Foundations of a Metamodel Repository for Use With the IEC Common Information Model

The development of the smart grid calls for enhanced power system application interoperability and knowledge management. The IEC Common Information Model (CIM) supports semantic interoperability but multiple identities attributed to common power system resources present challenges to unambiguous metadata model merging within a repository. This paper describes an original methodology for the building of a novel metadata model repository that concentrates our knowledge of enterprise power system resources. We leverage the value of model namespaces and resource description framework (RDF) technology in providing contexts for multiple identities referring to common power system resources. This novel approach aims to develop a more realistic understanding of network reality than repositories depending on a single CIM XML namespace and contributes to engineering an “enterprise ontology” supporting interoperability and business intelligence. We demonstrate this novel approach with reference to National Grid use cases for network operation and planning model management roles.
Calcium intake is not related to breast cancer risk among Singapore Chinese women

There is experimental evidence that calcium protects against breast cancer development. Prospective epidemiologic studies supporting a protective effect of calcium on breast cancer risk have mainly been limited to Western populations. We examined the association between calcium intake and breast cancer risk in the Singapore Chinese Health Study, a large population‐based prospective cohort. Calcium intake and supplement use was assessed by in‐person interviewer using a validated food frequency questionnaire. After a mean follow‐up of 14.2±3.5 years, 823 cohort participants developed invasive breast cancer. Multivariate proportional hazards regression models were fitted to examine the associations between calcium intake and breast cancer risk. Vegetables were the primary food source of calcium in this study population, followed by dairy products, grains and soy foods. Calcium intake was not associated with breast cancer risk, comparing highest quartile (>345.6 mg/1,000 kcal/day) to lowest quartile (<204.5 mg/1,000 kcal/day) of intake. There was no evidence of effect modification by menopausal status, body mass index, dietary vitamin D or stage of disease at diagnosis. Our findings do not support a hypothesis for calcium in breast cancer chemoprevention, contrary to findings from previous studies among Western populations with higher calcium intake primarily from dairy products and supplements.
Dynamic field map estimation using a spiral‐in/spiral‐out acquisition

The long readout times of single‐shot acquisitions and the high field strengths desired for functional MRI (fMRI) using blood oxygenation level‐dependent (BOLD) contrast make functional scans sensitive to magnetic field inhomogeneity. If it is not corrected during image reconstruction, field inhomogeneity can cause geometric distortions in the images when Cartesian k‐space trajectories are used or blurring with spiral acquisitions. Many traditional methods to correct for field inhomogeneity distortions rely on a static field map measured with the use of images that are themselves distorted. In this work, we employ a regularized least‐squares approach to jointly estimate both the undistorted image and field map at each acquisition using a spiral‐in/spiral‐out pulse sequence. Simulation and phantom studies show that this method is accurate and stable over a time series. Human functional studies show that the jointly estimated field map may be more accurate than standard field map estimates in the presence of respiration‐induced phase oscillations, leading to better detection of functional activation. The proposed method measures a dynamic field map that accurately tracks magnetic field drift and respiration‐induced phase oscillations during the course of a functional study. Magn Reson Med 51:1194–1204, 2004. © 2004 Wiley‐Liss, Inc.
Head and Neck Injuries in Professional Soccer

Objective:To investigate the rate of and risk factors for head and neck injury in male soccer. Design:Prospective cohort study. Setting:Professional soccer. Participants:Twenty-six European teams between 2001/2002 and 2009/2010. Assessment of Risk Factors:Simple and multiple risk factor analyses were evaluated using Cox regression for player-related variables and logistic regression for match-related variables. Main Outcome Measures:Injury rate (number of time loss injuries per 1000 hours). Results:A total of 136 head and neck injuries were recorded (2.2% of all injuries). The head and neck injury rate was 0.17 (0.06 concussions) per 1000 hours. There was a 20-fold higher rate of head and neck injury during match play compared with training (rate ratio [RR], 20.2; 95% confidence interval [CI], 13.3-30.6) and a 78-fold higher rate of concussions (RR, 78.5; 95% CI, 24.4-252.5). Mean layoff for concussion was 10.5 days, but 27% of the concussed players returned to play within 5 days. Defender was the only significant player-related risk factor for head and neck injuries in the multiple analysis (RR, 1.8; 95% CI, 1.0-3.1), whereas no significant variables were identified for concussions. Conclusions:Head and neck injuries were relatively uncommon in professional soccer. Defender was the playing position most at risk. More than one-quarter of the concussed players returned to play before what is recommended in the consensus statements by the major sports governing bodies.
The Spt5 C-Terminal Region Recruits Yeast 3′ RNA Cleavage Factor I

ABSTRACT During transcription elongation, RNA polymerase II (Pol II) binds the general elongation factor Spt5. Spt5 contains a repetitive C-terminal region (CTR) that is required for cotranscriptional recruitment of the Paf1 complex (D. L. Lindstrom et al., Mol. Cell. Biol. 23:1368–1378, 2003; Z. Zhang, J. Fu, and D. S. Gilmour, Genes Dev. 19:1572–1580, 2005). Here we report a new role of the Spt5 CTR in the recruitment of 3′ RNA-processing factors. Chromatin immunoprecipitation (ChIP) revealed that the Spt5 CTR is required for normal recruitment of pre-mRNA cleavage factor I (CFI) to the 3′ ends of Saccharomyces cerevisiae genes. RNA contributes to CFI recruitment, as RNase treatment prior to ChIP further decreases CFI ChIP signals. Genome-wide ChIP profiling detected occupancy peaks of CFI subunits around 100 nucleotides downstream of the polyadenylation (pA) sites of genes. CFI recruitment to this defined region may result from simultaneous binding to the Spt5 CTR, to nascent RNA containing the pA sequence, and to the elongating Pol II isoform that is phosphorylated at serine 2 (S2) residues in its C-terminal domain (CTD). Consistent with this model, the CTR interacts with CFI in vitro but is not required for pA site recognition and transcription termination in vivo.