Miracle-dz/UniFAR-FTUs huggingface dataset:
Discrepancies between Expected and Actual Implementation: The Process Evaluation of PERS Integration in Nursing Homes

Recent studies prove that when implementing new technology technology-driven and one-size-fits-all approaches are problematic. This study focuses on the process of implementing personal emergency response system (PERS) at nursing homes. The aim is to understand why the implementation of PERS has not met initial expectations. Multiple methods were used in two Swedish nursing homes, including document analysis, questionnaires (n = 42), participant observation (67 h), and individual interviews (n = 12). A logic model was used to ascertain the discrepancies that emerged between expected and actual implementation, and the domestication theory was used to discuss the underlying meanings of the discrepancies. The discrepancies primarily focused on staff competence, system readiness, work routines, and implementation duration. Corresponding reasons were largely relevant to management issues regarding training, the procurement systems, individual and collective responsibilities as well as invisible work. The uptake of technology in daily practice is far more nuanced than a technology implementation plan might imply. We point out the importance of preparing for implementation, adjusting to new practices, and leaving space and time for facilitating implementation. The findings will be of use to implementers, service providers, and organizational managers to evaluate various measures in the implementation process, enabling them to perform technology implementation faster and more efficiently.
Specific thermal ablation of tumor cells using single‐walled carbon nanotubes targeted by covalently‐coupled monoclonal antibodies

CD22 is broadly expressed on human B cell lymphomas. Monoclonal anti‐CD22 antibodies alone, or coupled to toxins, have been used to selectively target these tumors both in SCID mice with xenografted human lymphoma cell lines and in patients with B cell lymphomas. Single‐walled carbon nanotubes (CNTs) attached to antibodies or peptides represent another approach to targeting cancer cells. CNTs convert absorbed near‐infrared (NIR) light to heat, which can thermally ablate cells that have bound the CNTs. We have previously demonstrated that monoclonal antibodies (MAbs) noncovalently coupled to CNTs can specifically target and kill cells in vitro. Here, we describe the preparation of conjugates in which the MAbs are covalently conjugated to the CNTs. The specificity of both the binding and NIR‐mediated killing of the tumor cells by the MAb‐CNTs is demonstrated by using CD22+CD25− Daudi cells, CD22−CD25+ phytohemagglutinin‐activated normal human peripheral blood mononuclear cells, and CNTs covalently modified with either anti‐CD22 or anti‐CD25. We further demonstrate that the stability and specificity of the MAb‐CNT conjugates are preserved following incubation in either sodium dodecyl sulfate or mouse serum, indicating that they should be stable for in vivo use. © 2009 UICC
A Review of Web-Assisted Tobacco Interventions (WATIs)

Background The Internet has great potential to provide assistance to millions of smokers who seek help with quitting smoking. Objective The goals of this study were to assess the content and the quality of smoking cessation treatments most likely to be encountered by smokers seeking treatment on the Internet and to examine differences in quality between current websites and those reviewed in 2004. Methods Internet searches for smoking cessation were designed to mimic the search patterns of most Internet users. PhD-level specialists in tobacco cessation treatments used standardized procedures to review the content of each website, assess the degree to which each site covered key components of evidence-based treatment as described in US national guidelines, determine the accuracy of information presented, and evaluate the use of website interactivity. Results of the current study were compared to results obtained in a prior review. Results Most websites retrieved in the search met exclusion criteria and were not included in the final analyses in both the current (74%, 65/88) and the prior study (77%, 156/202). In both studies, the majority of websites were excluded because they sold cessation-related products but did not provide treatment recommended by the Public Health Service guidelines. Of the 23 websites included in the current study, 26% (n = 6) provided only minimal coverage (brief mention) of key components of tobacco treatment. However, compared to the earlier study, websites included in the present study scored significantly higher in quality ratings in four areas: providing advice to quit (P = .05), practical counseling (P = .02), and enhancing motivation to quit smoking through personal relevance (P = .05) and risks (P < .001). Most Web-assisted tobacco intervention (WATI) sites (69%, 16/23) contained no inaccurate information. When observed, inaccuracies primarily occurred in content related to pharmacotherapy. The percentage of sites offering at least one interactive feature increased from 39% (18/46) in 2004 to 56% (13/23) in the present study. Despite this improvement, there was a notable underutilization of the interactive capabilities of the Internet to personalize treatment, to connect users with a virtual support system, and to provide follow-up treatment contacts. Conclusions While the quality of treatment offered in WATIs has improved since our previous review in 2004, there is substantial room for further improvement to ensure that smokers are offered high-quality, evidence-based treatments. It is not clear what degree of informational detail and interactivity is optimal for Web-based smoking cessation treatments. Additional research is needed to understand how to maximize the interactive capabilities of the Internet to produce and sustain population-based health behavior change.
Why Do We Need to Use Three-Dimensional (3D) Fourier Transform (FT) Analysis to Evaluate a High-Performance Transmission Electron Microscope (TEM)?

Abstract The resolution of high-resolution transmission electron microscopes (TEM) has been improved down to subangstrom levels by correcting the spherical aberration (Cs) of the objective lens, and the information limit is thus determined mainly by partial temporal coherence. As a traditional Young’s fringe test does not reveal the true information limit for an ultra-high-resolution electron microscope, new methods to evaluate temporal coherence have been proposed based on a tilted-beam diffractogram. However, the diffractogram analysis cannot be applied when the nonlinear contribution becomes significant. Therefore, we have proposed a method based on the three-dimensional (3D) Fourier transform (FT) of through-focus TEM images, and evaluated the performance of some Cs-corrected TEMs at lower voltages. In this report, we generalize the 3D FT analysis and derive the 3D transmission cross-coefficient. The profound difference of the 3D FT analysis from the diffractogram analysis is its capability to extract linear image information from the image intensity, and further to evaluate two linear image contributions separately on the Ewald sphere envelopes. Therefore, contrary to the diffractogram analysis the 3D FT analysis can work with a strong scattering object. This is the necessary condition if we want to directly observe the linear image transfer down to a few tens of picometer.
DB2 Query Parallelism: Staging and Implementation

Intraquery parallelism has been recognized as a key requirement for DB2 major customers to allow data intensive queries with acceptable response time. DB2 delivers intraquery parallelism in three stages since DB2 Version 3 Release 1 in 1993. DB2 intraquery parallelism requires extensions on many DB2 components, such as optimizer, query executor, buffer manager, . etc. We briefly discuss the major issues in DB2 intraquery parallelism and the mechanisms used in our implementation.
Involvement of the 14-3-3 Gene Family in Autism Spectrum Disorder and Schizophrenia: Genetics, Transcriptomics and Functional Analyses

The 14-3-3 protein family are molecular chaperones involved in several biological functions and neurological diseases. We previously pinpointed YWHAZ (encoding 14-3-3ζ) as a candidate gene for autism spectrum disorder (ASD) through a whole-exome sequencing study, which identified a frameshift variant within the gene (c.659-660insT, p.L220Ffs*18). Here, we explored the contribution of the seven human 14-3-3 family members in ASD and other psychiatric disorders by investigating the: (i) functional impact of the 14-3-3ζ mutation p.L220Ffs*18 by assessing solubility, target binding and dimerization; (ii) contribution of common risk variants in 14-3-3 genes to ASD and additional psychiatric disorders; (iii) burden of rare variants in ASD and schizophrenia; and iv) 14-3-3 gene expression using ASD and schizophrenia transcriptomic data. We found that the mutant 14-3-3ζ protein had decreased solubility and lost its ability to form heterodimers and bind to its target tyrosine hydroxylase. Gene-based analyses using publicly available datasets revealed that common variants in YWHAE contribute to schizophrenia (p = 6.6 × 10−7), whereas ultra-rare variants were found enriched in ASD across the 14-3-3 genes (p = 0.017) and in schizophrenia for YWHAZ (meta-p = 0.017). Furthermore, expression of 14-3-3 genes was altered in post-mortem brains of ASD and schizophrenia patients. Our study supports a role for the 14-3-3 family in ASD and schizophrenia.
A 0.6–1V input capacitor-less asynchronous digital LDO with fast transient response achieving 9.5b over 500mA loading range in 65-nm CMOS

A 65-nm external capacitor-less asynchronous digital low drop-out regulator (DLDO) with adaptive sizing and fast transient response is presented in this paper. Operating at a wide input voltage range from as low as 0.6V to 1V, this DLDO is capable of delivering a maximum current of 500mA with 50mV drop-out voltage. The proposed adaptive sizing featured by row-column-bit 3-dimensional (3D) power stage and its asynchronous adaptive digital pipeline control have enabled a fast transient response to nanoseconds' loading current change and a 200mV per 10ns reference voltage switching, as well as a fine resolution of 768 levels (~9.5 bits) with a 5mV output ripple. The quiescent current consumed by this DLDO at steady operation is as low as 300μA over the whole input range.
Explicit Solutions to Separable Problems in Optimal Cooperative Control

This paper presents explicit state-space solutions for a class of networked cooperative control problems. We consider the optimal control problem for a class of systems with dynamics defined at the vertices of a directed acyclic graph, and dynamic propagation along the edges of the graph. The controller is also constrained to use information flowing along the edges of the graph. With the additional assumption of transitive closure, such problems have linear optimal controllers. We show that, under the factorization condition that every disturbance non-sink takes state feedback, these problems separate into several independent subproblems and hence they can be explicitly solved. This technique generalizes and unifies several existing approaches for optimal decentralized control, and it further provides the optimal controller for many cases in which the optimal control was previously unknown. The optimal solutions are expressed in terms of a series of Riccati equations whose sizes are bounded by the system order. The separated problems highlight the structure of the optimal controller. We demonstrate our approach on a salvo guidance problem for a team of networked missiles.
Epidemiology of Massive Transfusion: A Binational Study From Sweden and Denmark*

Objective:There is an increasing focus on massive transfusion, but there is a paucity of comprehensive descriptions of the massively transfused patients and their outcomes. The objective of this study is to describe the incidence rate of massive transfusion, patient characteristics, and the mortality of massively transfused patients. Design:Descriptive cohort study. Setting:Nationwide study with data from Sweden and Denmark. Patients:The study was based on the Scandinavian Donations and Transfusions database, including all patients receiving 10 or more red cell concentrate transfusions in Sweden from 1987 and in Denmark from 1996. A total of 92,057 patients were included. Patients were followed until the end of 2012. Measurements and Main Results:Descriptive statistics were used to characterize the patients and indications. Post transfusion mortality was expressed as crude 30-day mortality and as long-term mortality using the Kaplan-Meier method and using standardized mortality ratios. The incidence of massive transfusion was higher in Denmark (4.5 per 10,000) than in Sweden (2.5 per 10,000). The most common indication for massive transfusion was major surgery (61.2%) followed by trauma (15.4%). Massive transfusion due to obstetrical bleeding constituted only 1.8%. The overall 5-year mortality was very high (54.6%), however with large differences between indication groups, ranging from 91.1% among those transfused for a malignant disease without surgery to 1.7% among patients transfused for obstetrical bleeding. The early standardized mortality ratios were high and decreased thereafter, but remained elevated throughout the time period. Conclusions:This large-scale study based on nationwide data from Sweden and Denmark describes the complete range of massive transfusion. We report a nonnegligible incidence and both a high absolute mortality and high standardized mortality ratio. The general pattern was similar for Sweden and Denmark, and we believe that similar patterns may be found in other high-resource countries. The study provides a relevant background for clinicians and researchers for designing future studies in this field.
STEADY-STATE CHARACTERISTICS ANALYSIS OF DEEP-SEA RUNNING MECHANISM WITH PLANETARY GEAR WHEEL BASED ON ARTICULATED STEERING RADIUS

Steady-state characteristics analysis for the deep-sea running mechanism with planetary gear train which is designed to adapt to complex terrain in the deep-sea hydrothermal sulfide and rich-cobalt incrustation survey area is based on articulated steering radius. The articulated steering radius formula of the deep-sea running mechanism is derived from the geometric relationship, considering the wheel side slip angle. Based on the formula, three types of steering steady-state characteristic analysis, understeer, neutral steer and oversteer, are made for the mechanism. Steering simulation analysis of the running mechanism with planetary gear is conducted in ADAMS software with different speed. In the process of steering, the side slip angle increases first, then gradually decreases and finally tends to be stable. The side slip angle of the front wheels is greater than that of the rear wheels. While the speed of steering turns to be faster, wheel side slip angle and steering radius increase. The mechanism is understeer, and performs good handling stability characteristic.
Impact of integrated graphical display on expert and novice diagnostic performance in critical care

OBJECTIVE To determine the impact of a graphical information display on diagnosing circulatory shock. MATERIALS AND METHODS This was an experimental study comparing integrated and conventional information displays. Participants were intensivists or critical care fellows (experts) and first-year medical residents (novices). RESULTS The integrated display was associated with higher performance (87% vs 82%; P < .001), less time (2.9 vs 3.5 min; P = .008), and more accurate etiology (67% vs 54%; P = .048) compared to the conventional display. When stratified by experience, novice physicians using the integrated display had higher performance (86% vs 69%; P < .001), less time (2.9 vs 3.7 min; P = .03), and more accurate etiology (65% vs 42%; P = .02); expert physicians using the integrated display had nonsignificantly improved performance (87% vs 82%; P = .09), time (2.9 vs 3.3; P = .28), and etiology (69% vs 67%; P = .81). DISCUSSION The integrated display appeared to support efficient information processing, which resulted in more rapid and accurate circulatory shock diagnosis. Evidence more strongly supported a difference for novices, suggesting that graphical displays may help reduce expert-novice performance gaps.
Control of DFIG under unbalanced grid voltage conditions: A literature review

Because of increasing generation of electricity from non-conventional sources all over the world including India, there is heavy demand for Doubly Fed Induction Generator (DFIG) as it possess several merits over other conventional generators. This papers presents a literature review for control of DFIG based wind energy conversion systems under unbalanced grid voltage conditions. Various techniques of control such as conventional control, vector control, direct and predictive controls etc are covered in this work. Further in this paper, a comparative analysis is presented in tabular for better understanding of this work.
Advanced hybrid satellite and terrestrial system architecture for emergency mobile communications

Emergency situations require reliable broadband communications systems which are able to transmit relevant information from the disaster site to the decision makers and send feedback to first responders regarding potential dangers or decisions. A key factor in designing a robust communications system with applications to emergency response is the development of a quick, easily deployable and mobile infrastructure, providing voice and data communications, available within the first 24 hours - the most critical phase for crisis operations. In this paper, an advanced hybrid satellite and terrestrial system for emergency mobile communications, that is quickly deployable and dynamically adaptable to disasters of any nature and location, is proposed as a potential solution to the above requirements. The overall architecture is IPv6-based and we present and emphasize the important role of Vehicle Communication Gateways (VCGs) in the system. Thanks to the satellite and wireless interfaces, VCGs are able to connect via satellite the disaster area with the headquarters, to create an inter-vehicular mobile ad-hoc mesh network in the emergency field and to provide connectivity to isolated IPv6 cells. Two types of VCGs are envisaged from a satellite interface point of view, S-UMTS vehicles operating in L or S band and nomadic DVB-RCS vehicles operating in Ku or Ka band.
Common and distinct neural networks involved in fMRI studies investigating morality: an ALE meta-analysis

ABSTRACT Morality is an important social construct necessary for understanding what is right and wrong. Neuroimaging studies investigating morality have used a wide variety of paradigms and implicated many different brain areas. Yet, it remains unclear whether differences amongst morality tasks are the cause for such heterogeneous findings. Therefore, in the present study, a series of activation likelihood estimation (ALE) meta-analyses were conducted on 123 datasets (inclusive of 1963 participants) to address this question. The ALE meta-analyses revealed a series of common brain areas associated with all moral tasks, including medial prefrontal cortex, lateral orbitofrontal cortex, amygdala, temporoparietal junction, and precuneus. However, individual and contrast analyses also revealed unique networks associated with each moral modality, suggesting that different moral tasks recruit specialised brain regions.
Forward-secure identity-based signature with efficient revocation

ABSTRACT The security of traditional identity-based signature (IBS) is totally built upon the assumption that the private key is absolutely secure. However, with the increasing use of mobile and unprotected devices in today's cryptosystems, the threat of key exposure represents a more serious and realistic concern. To mitigate the damage of key exposure in the setting of IBS, we propose to integrate key evolution and user revocation into IBS, and present forward-secure identity-based signature with user revocation (FS-RIBS). Specifically, we formalize the syntax and security definition of FS-RIBS, and give a concrete construction. The proposed scheme is proven secure in the standard model under a q-type complexity assumption. To demonstrate the merits of our scheme, we theoretically analyse its performance by comparing it with other related works. Moreover, we provide an implementation and the corresponding timing results of our scheme to show its practicability.
Magnetic Resonance Imaging Interpretation in Patients With Symptomatic Lumbar Spine Disc Herniations: Comparison of Clinician and Radiologist Readings

Study Design. Retrospective review of imaging data from a clinical trial. Objective. To compare the interpretation of lumbar spine magnetic resonance imaging (MRIs) by clinical spine specialists and radiologists in patients with lumbar disc herniation. Summary of Background Data. MRI is the imaging modality of choice for evaluation of the lumbar spine in patients with suspected lumbar disc herniation. Guidelines provide standardization of terms to more consistently describe disc herniation. The extent to which these guidelines are being followed in clinical practice is unknown. Methods. We abstracted data from radiology reports from patients with lumbar intervertebral disc herniation enrolled in the Spine Patient Outcomes Research Trial. We evaluated the frequency with which morphology (e.g., protrusions, extrusions, or sequestrations) was reported as per guidelines and when present we compared the morphology ratings to those of clinicians who completed a structured data form as part of the trial. We assessed agreement using percent agreement and the &kgr; statistic. Results. There were 396 patients with sufficient data to analyze. Excellent agreement was observed between clinician and radiologist on the presence and level of herniation (93.4%), with 3.3% showing disagreement regarding level, of which a third could be explained by the presence of a transitional vertebra. In 3.3% of the cases in which the clinician reported a herniation (protrusion, extrusion, or sequestration), the radiologist reported no herniation on the MRI. The radiology reports did not clearly describe morphology in 42.2% of cases. In the 214 cases with clear morphologic descriptions, agreement was fair (&kgr; = 0.24) and the disagreement was asymmetric (Bowker’s test of symmetry P < 0.0001) with clinicians more often rating more abnormal morphologic categories. Agreement on axial location of the herniation was excellent (&kgr; = 0.81). There was disagreement between left or right side in only 3.3% of cases (&kgr; = 0.93). Conclusion. Radiology reports frequently fail to provide sufficient detail to describe disc herniation morphology. Agreement between MRI readings by clinical spine specialists and radiologists was excellent when comparing herniation vertebral level and location within level, but only fair comparing herniation morphology.
Word Re-Embedding via Manifold Dimensionality Retention

Word embeddings seek to recover a Euclidean metric space by mapping words into vectors, starting from words co-occurrences in a corpus. Word embeddings may underestimate the similarity between nearby words, and overestimate it between distant words in the Euclidean metric space. In this paper, we re-embed pre-trained word embeddings with a stage of manifold learning which retains dimensionality. We show that this approach is theoretically founded in the metric recovery paradigm, and empirically show that it can improve on state-of-the-art embeddings in word similarity tasks 0.5 - 5.0% points depending on the original space.