Miracle-dz/UniFAR-FTUs huggingface dataset:
Mouse Transplant Models for Evaluating the Oncogenic Risk of a Self-Inactivating XSCID Lentiviral Vector

Hematopoietic stem cell gene therapy requires the use of integrating retroviral vectors in order to stably transmit a therapeutic gene to mature blood cells. Human clinical trials have shown that some vector integration events lead to disrupted regulation of proto-oncogenes resulting in disordered hematopoiesis including T-cell leukemia. Newer vectors have been designed to decrease the incidence of these adverse events but require appropriate pre-clinical assays to demonstrate safety. We have used two distinct mouse serial transplant assays to evaluate the safety of a self-inactivating lentiviral vector intended for use in X-linked severe combined immunodeficiency (XSCID) gene therapy trials. These experiments entailed 28 months of total follow-up and included 386 mice. There were no cases in which the XSCID lentiviral vector clearly caused hematopoietic malignancies, although a single case of B cell malignancy was observed that contained the lentiviral vector as a likely passenger event. In contrast, a SFFV-DsRed γ-retroviral vector resulted in clonal transformation events in multiple secondary recipients. Non-specific pathology not related to vector insertions was noted including T cell leukemias arising from irradiated recipient cells. Overall, this comprehensive study of mouse transplant safety assays demonstrate the relative safety of the XSCID lentiviral vector but also highlight the limitations of these assays.
Routing and Wavelength Assignment in WDM Networks with Bounded-Degree Tree and Tree of Rings Topologies

In all-optical networks that use wavelength division multiplexing (WDM) technique, a challenging problem called the routing and wavelength assignment problem (RWA) is modelled as that connection requests must be assigned paths and wavelengths such that intersecting paths receive different wavelengths, and the goal is to minimize the number of wavelengths used. Besides the tree, another popular network topology is the tree of rings which is obtained by interconnecting rings in a tree structure such that any two rings share at most one node. A polynomial-time optimal algorithm and an approximation algorithm are given for the RWA problem in bounded-degree tree and tree of rings networks, respectively.
A novel microstrip fractal antenna with dual polarization

In this paper, a novel Microstrip Fractal patch antenna with dual polarization, which operates in a frequency band of 2-4 GHz (S-band) is proposed. Two challenging issues in the design of dual polarized antennas are obtaining high isolations and low cross polarized levels. Here we propose a technique to overcome these drawbacks by making use of the fractal geometry. The use of fractal geometry will improve bandwidth and reduce isolation loss. These geometries can also improve impedance matching. The proposed fractal antenna shows multiband characteristics by which the bandwidth can be improved. Sierpinski carpet fractal structure is used which shows high isolation compared to conventional dual patch antenna. Simulations are done by using Ansoft High Frequency Structure Simulator (HFSS) software. The proposed antenna finds its application in weather radars, communication satellites and wireless communications with improved bandwidth.
Tag-based User Topic Discovery Using Twitter Lists

In this paper, we address the problem of tagging users in Twitter, one of the most popular micro-blogging services. There are growing needs to get useful information from Twitter, because an enormous amount of information is transmitted in real time. Twitter users, who play an important role as information sources, typically transmit information about some particular topics which they are interested in. Therefore, to identify useful information, it is very important to know which topics a user tends to transmit. In this paper, we propose a method to discover appropriate topics for a user by using Twitter list. Twitter list is an official functionality to make a"user list, " list members tend to transmit information about the topic represented in the name of the list. From this observation, our idea is to extract tags from list names, and exploit the relationship among lists, tags extracted from the list names, and list members. Experimental results show the effectiveness of the proposed method.
Design of Low-Cost Noise Measurement Sensor Network: Sensor Function Design

In this paper, we report the sensor function design and implementation of a wireless sensor network application for measuring environmental acoustic noise. The system is built on ATmega128 and CC2420 platform. The protocol stack is based on CiNet stack with a global synchronization scheme and supports multi-hop communications. Strict filtering function specified by ITU-R 468 (namely A-weighting) is followed. Both the indoor and outdoor test results were compared with standard sound level meters (CESVA SC-20c and Pulsar94) and showed a less than ±2dB error in both short-term and longterm measurement. Power consumption has been measured that a single AA-type battery can sustain the application. Comparing to the traditional noise measurement method, our wireless sensor network solution is much lower in cost, able to offer real-time data with sensed data timely coherent, and requests least attention after deployment.
Reputation Model Based on Trusted Group and Interaction Scene

Spam calls irritate people a lot. Many methods have been proposed to filter spam calls under different backgrounds. Regarding the sociology and psychology as a guide, we tried to propose a reputation model that can work in most backgrounds. In this paper, we proposed a reputation model based on trusted group and interaction scene, and then simulate the system and analysis the results. It appears a satisfactory performance and a rapid learning speed.
Flicker Mitigation With a Hybrid Compensator

This paper concentrates on a solution for the voltage flicker problem caused by a resistance spot welding process. Resistance spot welding is characterized by high currents lasting for a few mains voltage periods and followed by idle time lasting several cycles. This causes repetitive voltage changes and creates a phenomenon called flicker. Voltage fluctuations are difficult to compensate since the length of the welding period, the delay time between cycles, and the amplitude of currents may vary substantially. In the literature, active compensators such as active filters have been found effective in compensating changing loads, providing fast compensating responses. However, they should be rated on the basis of the maximum compensating power needed. This paper examines a solution based on a hybrid compensator. The system consists of an active compensator and a fixed detuned filter. The main task of the active part is to compensate changes in the fundamental reactive power, whereas the passive part provides a reduction in the ratings of the active compensator. Since the active part incorporates an active filter, load current harmonics are also compensated as a "by-product. " The system stability is analyzed, and the performance is examined in simulations and practical experiments. The resulting flicker severity indices are also assessed. The results show that with the proposed system, voltage fluctuations and flicker levels can be greatly reduced. The dynamics of the combination are found to be fast enough to compensate the rapid variations in the reactive power of the plant. A further benefit is smoothed instantaneous active power drawn from the mains.
RESTRICTION OF GENE EXPRESSION IN B LYMPHOCYTES AND THEIR PROGENY

Lymphocytes from b 5/b 9 rabbits were stained in suspension with fluorescent antiallotype antibody reagents to selectively label with fluorescent molecules those cells bearing membrane immunoglobulin (Ig) of the b5 or b9 allotype. After staining, the cells were separated by the fluorescence-activated cell sorter into populations markedly enriched in cells bearing b5 or b9 membrane Ig or totally depleted of cells with detectable membrane Ig. The potential of these separated cells to give rise to Ig-synthesizing plasma cells either in vivo after transfer into irradiated recipients or in vitro during culture in the presence of phytohemagglutinin or pokeweed mitogen was assessed by immunofluorescence. The relative proportion of b5 and b9 cytoplasmic Ig-stained cells (CSC) arising from the separated cells was determined to test directly whether B lymphocytes and their progeny are committed to the synthesis of Ig of one allotype. It was found that b5- and b9-bearing cells gave rise almost exclusively to b5- and b9-producing plasma cells, respectively, in both the in vivo and in vitro assay systems. Most of these CSC were probably not derived from previously existing CSC but arose as the result of the differentiation of lymphocytes with membrane Ig. When cell populations totally depleted of Ig-bearing lymphocytes were cultured, very few CSC were found, indicating that the majority of immediate precursors of CSC have membrane Ig. These results suggest that individual B cell clones are phenotypically restricted to the expression of immunoglobulin genes on one chromosome; the significance of this clonal allelic exclusion is discussed.
EXPERIMENTAL TRANSMISSION OF CUTANEOUS CHYTRIDIOMYCOSIS IN DENDROBATID FROGS

In a series of three experiments during March–October, 1998, two species of captive-bred poison dart frogs (Dendrobates tinctorius and D. auratus) were exposed to Batrachochytrium dendrobatidis, a recently-described chytridiomycete fungus (chytrid) that was originally isolated from a blue poison dart frog (D. azureus). All frogs exposed to the chytrids developed a fatal skin disease, whereas none of the control frogs developed skin lesions. The most consistent clinical sign in chytrid-exposed frogs was excessive shedding of skin. Gross lesions were subtle, usually affected the legs and ventrum, and consisted of mild skin thickening and discoloration. Microscopic examination of shed skin pieces and/or skin imprints demonstrated the presence of chytrids and was used for ante mortem and post mortem confirmation of chytrid infection. Histologically, there was epidermal hyperkeratosis, hyperplasia, and hypertrophy associated with low to moderate numbers of chytrids in the keratinized layers. These experiments demonstrated that Batrachochytrium dendrobatidis can be a fatal pathogen in poison dart frogs. The experimentally-induced disease in these frogs resembled cases of cutaneous chytridiomycosis that have recently been described in several other species of captive and wild amphibians.
Crystallization in Large Wireless Networks Contractual Date of Delivery to the CEC : March 25 , 2007 Actual Date of Delivery to the CEC : Author ( s ) :

In this deliverable, we analyze fading interference relay networks where M single-antenna source-destination terminal pairs communicate concurrently and in the same frequency band through a set of K single-antenna relays using half-duplex two-hop relaying. We assume that relays have channel state information (CSI), perform matched-filtering, and the destination terminals cannot cooperate. The main contributions of the report are: * We consider two different protocols, P1 introduced (for the finite-M case) in [14] and P2 introduced in [13]. P1 relies on the idea of relay partitioning and requires each relay terminal to know one backward (source to relay) and one forward (relay to destination) fading coefficient only. P2 does not use relay partitioning and requires each relay terminal to know all M backward and all M forward fading coefficients. We prove that in the large-M limit, provided the number of relay terminals grows fast enough as a function of M, under both protocols, the network " decouples " in the sense that the individual source-destination terminal pair capacities are strictly positive. The corresponding minimum rates of growth are shown to be K=M^3 for P1 and K=M^2 for P2. The protocols P1 and P2 are thus found to trade off CSI at the relays for the required (for the network to decouple) rate of growth of relays. * We show that the growth rates K=M^3 for P1 and K=M^2 for P2 are sufficient to not only make the network decouple, but to also lead to the individual source-destination fading links converge to nonfading links. We say that the network " crystallizes " as it breaks up into a set of isolated " wires in the air ". A large-deviations analysis is performed to characterize the " crystallization " rate, i.e., the rate (as a function of M, K) at which the decoupled links converge to nonfading links. In the course of this analysis, we develop a new technique for characterizing the large-deviations behavior of certain sums of dependent random variables. * For P1 and P2, we establish the impact of cooperation at the relay level on network capacity scaling. More specifically, it is shown that, asymptotically in M and K, cooperation in groups of L relays (which can also be interpreted as having multi-antenna relays in MEMBRANE settings) leads to an L-fold reduction in the total number of relays needed to achieve a given per source-destination terminal pair capacity.
A Tactile Display System for Hand Prostheses to Discriminate Pressure and Individual Finger Localization

No current commercially available myoelectrically controlled prosthetic hands provide conscious sensory feedback to the user. A system aiming at relocation of sensory input from a prosthetic hand equipped with force sensors to the forearm skin of amputees, a tactile display, has been developed and constructed. The system consists of five piezoresistive force sensors or, alternatively, a prosthetic hand equipped with three sensors, five digital servomotors with a lever and a circular plastic disk pushing on the skin, control electronics based on an MSP430 microcontroller and a test application implemented in LabVIEW running on a PC. The tactile display system is intended to be integrated into the socket of a hand prosthesis and used as a conscious sensory feedback system for hand amputees using a myoelectrically controlled hand prosthesis. The system will provide continuous force feedback from sensors in the fingertips of each prosthetic finger and will likely improve the users' controllability and perception of the prosthetic hand. Here we report on tests made on ”a five site” localization discrimination task and three pressure level discrimination tasks on the forearm of live healthy participants (non-amputees) using the LabView application to generate the stimulations. A mean live-linger discrimination accuracy of 86% and a mean three-level pressure discrimination accuracy of 93% were achieved, indicating the system to he a viable method of producing sensory feedback on the level of individual fingers.
A new fuzzy rule-based initialization method for K-Nearest neighbor classifier

The performances of conventional crisp and fuzzy K-Nearest neighbor (K-NN) algorithms trained using finite samples tends to be poor [1], [2]. With “holes” in the training data, it is unlikely that the decision area formed can actually represent the underlying data distribution. There is a need to capture more useful information from the limited training samples, therefore we propose a new fuzzy rule-based K-NN algorithm. A fuzzy rule-based initialization procedure differentiates our proposed algorithm from the conventional fuzzy K-NN algorithm. The new initialization procedure allows us to handle the imprecise inputs (neighborhood density and distance) through the natural framework of fuzzy logic system. Unlike conventional K-NN algorithms, the ability to fine tune the membership functions can lead to a highly versatile decision boundary. Thus, the new algorithm can be specifically tuned for different problems to achieve better results. The advantage is demonstrated on a synthetic data set in two-dimensional space. In addition, we also adopt weighted Euclidean distance measurement to overcome the curse of dimensionality [3]. The Euclidean distance weights and the parameters of the fuzzy rule-based system are then optimized with Genetic Algorithm (GA) simultaneously. The practical applicability of the proposed algorithm is verified on four UCI data sets (Bupa liver disorders, Glass, Pima Indians diabetes and Wisconsin breast cancer) and Ford automotive data set with an improvement of 3.42% in classification rate on average.
Child video Dataset Tool to Develop Object tracking simulates Babysitter Vision robot

This study presents a Child Video Dataset (CVDS) that has numerous videos of different ages and situation of children. To simulate a babysitter’s vision, our application was developed to track objects in a scene with the main goal of creating a reliable and operative moving child-object detection system. The aim of this study is to explore novel algorithms to track a child-object in an indoor and outdoor background video. It focuses on tracking a whole child-object while simultaneously tracking the body parts of that object to produce a positive system. This effort suggests an approach for labeling three body sections, i.e., the head, upper and lower sections and then for detecting a specific area within the three sections and tracking this section using a Gaussian Mixture Model (GMM) algorithm according to the labeling technique. The system is applied in three situations: Child-object walking, crawling and seated moving. During system experimentation, walking object tracking provided the best performance, achieving 91.932% for body-part tracking and 96.235% for whole-object tracking. Crawling object tracking achieved 90.832% for body-part tracking and 96.231% for whole object tracking. Finally, seated-moving-object tracking achieved 89.7% for body-part tracking and 93.4% for whole-object tracking.
Regularity lemma basics ( bibliography )

1. The introduction (motivation by van der Waerden Theorem and Erdős – Turán conjecture) was inspired by initial two chapters of ‘Ramsey Theory’ [15]. The Erdős – Turán conjecture (rk(n) = o(n), where rk(n) is the size of a largest subset of {1, . , n} without an arithmetic progression of length k) appeared in [8]. Roth proved this conjecture for k = 3 in [36] and in a stronger form in [37]. Szemerédi’s proof of the case k = 4 is in [39] and the full conjecture is proved in [40].
Minimization of wideband LTCC bandpass filter using QMSIW and EMSIW cavities

A compact wide passband three-pole LTCC filter is presented; its electrical size is reduced by exploiting quarter substrate integrated waveguide (QMSIW) and eighth-mode SIW (EMSIW) cavities, which is smaller than conversional SIW. The filter is designed on multilayer ceramic, which make the filter further compact. The filter was simulated by full wave simulator. The simulated results show the filter has wide passband, which is centered at 11.2 GHz with 23.6% bandwidth. The volume of the filter is only 8.0×5.0×0.6mm3.
KineticStudy of the Jaff # { 233 } Reactionfor QuantifyingCreatininein Serum : 2 . Evaluationof BufferedReagent and Comparisonof DifferentData-ProcessingOptions

Here we describethe evaluationof several data-processing options for the kinetic determination of creatinine by use of theJaff#{233} reaction. Data-processing options evaluated include initial-rate,two-point fixed-time, rate at t = k1, and multipoint curve-fittingpredictivemethods. We evaluated these options for a buffered formulation of the Jaff#{233} reagent and studied the effects of potential interferents, including glucose, acetoacetate, bilirubin, and albumin, on each option. To reduce effects of biiirubin, we evaluated the inclusion of a preoxidation step with ferricyanide. All the data-processing options gave good precision and linearity between the measurement objective and creatinine concentration. However, differences between slopes of calibration plots in aqueous and serum matrices ranged from a high of + 60% for the twopoint, fixed-time method to a low of -11% for the curvefitting, predictive method. Standard additions of creatinine to sera were quantified reliably (yielding 96% to 102% of target values) by the predictive method and less reliably (62% to 102%) by the other methods. We conclude that the predictive methodhas the potentialto yieldthe most reliableresultsfor creatinine.
Tele-robotics : Distributed Training-oriented Navigation Framework

The purpose of this article is to present a tele-robotic application, developed on an advanced demonstration platform, incorporating reflexive tele-operated control concepts elaborated on a mobile robot system. By voice command, the operator controls the behavior of the robot, being 1 out of 4 levels of robot-operator interaction, while environmental exploration is possible by means of the head mounted display in combination with an inertial tracker. Based on the distributed framework, named Controlling Robots with CORBA (CoRoBa), results of the tuned robot navigation strategy are presented. The results achieved might also be used in domains such as surveillance, remote monitoring and risky interventions.
Building adaptive distributed applications with middleware and aspects

Middleware technologies allow the development of distributed applications without explicit knowledge of the networking involved. However, in the face of changing network and CPU conditions across the distributed system, these applications often will need to adapt their behavior to maintain an acceptable quality of service (QoS), which implies a knowledge of these conditions. This adaptation is neither part of the application logic nor part of the distribution middleware, and so represents a separate concern which needs to be addressed.This paper describes an aspect-based approach to programming QoS adaptive applications that separates the QoS and adaptation concerns from the functional and distribution concerns. To simplify aspect development for these applications, our approach integrates a domain-specific adaptation specification with a novel aspect language which includes distribution and adaptation-specific join points in its join point model. We compare and contrast this with existing aspect-oriented language approaches and illustrate our approach with an example distributed system application.