Miracle-dz/UniFAR-FTUs huggingface dataset:
Reducing empirical use of fluoroquinolones for Pseudomonas aeruginosa infections improves outcome.

BACKGROUND We previously reported ciprofloxacin resistance (CR) and empirical use of fluoroquinolones as predictors of mortality in patients infected with Pseudomonas aeruginosa in a case-control study. Here, we assessed the clinical impact of reducing empirical fluoroquinolone use for P. aeruginosa infections in hospitalized patients by performing a follow-up study in 2005-06 [period 2 (P2)] and comparing this with prior data from 2001-02 [period 1 (P1)]. METHODS Medical charts of infected patients who received at least 72 h of antibiotic therapy were reviewed. Patients were subgrouped based on the susceptibility of infected strains into the CR or ciprofloxacin-susceptible group. Antibiograms, patient and treatment variables and outcome measures were compared between groups and between study periods. RESULTS Study patients were elderly (median age, 76 years), had a median of three co-morbidities and a median APACHE II score of 13. Most (75%) had pneumonia or urosepsis. Empirical use of fluoroquinolones was reduced by 30% in P2 versus P1, with a corresponding 39% increase in piperacillin/tazobactam use. The resultant positive impact observed in the CR group during P2 includes shortened delay to receipt of effective therapy (1 versus 3.5 days, P < 0.0001), reduced length of stay (13 versus 16 days, P = 0.03) and 2-fold lower mortality (9% versus 22%, P = 0.05). Susceptibility of P. aeruginosa improved by 10% to all antipseudomonal agents tested. CONCLUSIONS In settings where high rates of fluoroquinolone resistance exist, use of non-fluoroquinolone-based empirical regimens for P. aeruginosa infections improves patient outcomes and organism susceptibility over time.
HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production

α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (AMPA-R) potentiators with brain-derived neurotrophic factor (BDNF)–induction potential could be promising as therapeutic drugs for neuropsychiatric and neurologic disorders. However, AMPA-R potentiators such as LY451646 have risks of narrow bell-shaped responses in pharmacological effects, including in vivo BDNF induction. Interestingly, LY451646 and LY451395, other AMPA-R potentiators, showed agonistic effects and exhibited bell-shaped responses in the BDNF production in primary neurons. We hypothesized that the agonistic property is related to the bell-shaped response and endeavored to discover novel AMPA-R potentiators with lower agonistic effects. LY451395 showed an agonistic effect in primary neurons, but not in a cell line expressing AMPA-Rs, in Ca2+ influx assays; thus, we used a Ca2+ influx assay in primary neurons and, from a chemical library, discovered two AMPA-R potentiators with lower agonistic effects: 2-(((5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide (HBT1) and (3S)-1-(4-tert-butylphenyl)-N-((1R)-2-(dimethylamino)-1-phenylethyl)-3-isobutyl-2-oxopyrrolidine-3-carboxamide (OXP1). In a patch-clamp study using primary neurons, HBT1 showed little agonistic effect, whereas both LY451395 and OXP1 showed remarkable agonistic effects. HBT1, but not OXP1, did not show remarkable bell-shaped response in BDNF production in primary neurons. HBT1 bound to the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner. The mode of HBT1 and LY451395 binding to a pocket in the LBD of AMPA-R differed: HBT1, but not LY451395, formed hydrogen bonds with S518 in the LBD. OXP1 may bind to a cryptic binding pocket on AMPA-R. Lower agonistic profile of HBT1 may associate with its lower risks of bell-shaped responses in BDNF production in primary neurons.
Dietary Intake of Eicosapentaenoic and Docosahexaenoic Acid and Diabetic Nephropathy: Cohort Analysis of the Diabetes Control and Complications Trial

OBJECTIVE To investigate the association between dietary n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) and the degree and development of albuminuria in type 1 diabetes. RESEARCH DESIGN AND METHODS We analyzed longitudinal data from 1,436 participants in the Diabetes Control and Complications Trial. We defined the average intake of eicosapentaenoic and docosahexaenoic acid from diet histories. Urinary albumin excretion rates (UAERs) were measured over 24 h; incident albuminuria was considered the first occurrence of an UAER >40 mg/24 h sustained for ≥1 year in normoalbuminuric individuals. RESULTS In a mean follow-up of 6.5 years, we observed a lower mean UAER (difference 22.7 mg/24 h [95% CI 1.6–43.8)]) in the top versus the bottom third of dietary n-3 LC-PUFAs, but we found no association with incident albuminuria. CONCLUSIONS Dietary n-3 LC-PUFAs appear inversely associated with the degree but not with the incidence of albuminuria in type 1 diabetes. These findings require further investigation in prospective studies.
Effects of In and Sb addition on the thermal and wetting behavior of Sn-3.5Ag solder

Purpose This paper aims to investigate the effect of In and Sb additions on the thermal behavior and wettability of Sn-3.5Ag-xIn-ySb (x = 0, 1.0 and 1.5 Wt.%, y = 0, 1.0, 1.4 and 2.1 Wt.%) solder alloys. Design/methodology/approach The thermal behavior of the Pb-free solder alloys was studied using differential scanning calorimetry. Wetting balance experiments were performed in accordance with the IPC standard, IPC-TM-650 and at a temperature of 260°C. Also, a solder spread test was performed on a Cu surface finish using the JIS-Z-3197 solderability standard. Findings It is shown that among the selected Sn-3.5Ag-xIn-ySb (x = 0, 1.0 and 1.5 Wt.%, y = 0, 1.0, 1.4 and 2.1 Wt.%) alloys, Sn-3.5Ag-1.5In-1Sb showed the lowest melting point and the lowest undercooling temperature. The best wettability was achieved when the In and Sb contents were approximately 1.5 and 1.0 Wt. %, respectively. The effect of the combined addition of In and Sb on solder spreadability on a Cu substrate was also demonstrated. Originality/value It was found that adding approximately 1.5 and 1.0 Wt. % of In and Sb, respectively, in Sn-3.5Ag solder provided the best wetting performance and improved the solder spreadability.
Integrating sequence and gene expression information predicts genome-wide DNA-binding proteins and suggests a cooperative mechanism

Abstract DNA-binding proteins (DBPs) perform diverse biological functions ranging from transcription to pathogen sensing. Machine learning methods can not only identify DBPs de novo but also provide insights into their DNA-recognition dynamics. However, it remains unclear whether available methods that can accurately predict DNA-binding sites in known DBPs can also identify novel DBPs. Moreover, sequence information is blind to the cellular- and disease-specific contexts of DBP activities, whereas the under-utilized knowledge from public gene expression data offers great promise. To address these issues, we have developed novel methods for predicting DBPs by integrating sequence and gene expression-derived features and applied them to explore human, mouse and Arabidopsis proteomes. While our sequence-based models outperformed the gene expression-based ones, some proteins with weaker DBP-like sequence features were correctly predicted by gene expression-based features, suggesting that these proteins acquire a tangible DBP functionality in a conducive gene expression environment. Analysis of motif enrichment among the co-expressed genes of top 100 candidates DBPs from hitherto unannotated genes provides further avenues to explore their functional associations.
Multiparty Communication Complexity of AC^0

We prove n (1) lower bounds on the multiparty communication complexity of AC 0 functions in the number-on-forehead (NOF) model for up to �(logn) players. These are the first lower bounds for any AC 0 function for ! (loglogn) players. In particular we show that there are families of depth 3 read-once AC 0 formulas having k-player randomized multiparty NOF communication complexity n (1) /2 O(k) . We show similar lower bounds for depth 4 read-once AC 0 formulas that have nondeterministic communication complexity O(log 2 n), yielding exponential separations between k-party nondeterministic and randomized communication complexity for AC 0 functions. As a consequence of the latter bound, we obtain an n (1/k) /2 O(k) lower bound on the k-party NOF communication complexity of set disjointness. This is non-trivial for up to �( p logn) players which is significantly larger than the up to �(loglogn) players allowed in the best previous lower bounds for multiparty set disjointness given by Lee and Shraibman [LS08] and Chattopadhyay and Ada [CA08] (though our complexity bounds themselves are not as strong as those in [LS08, CA08] for o(loglogn) players). We derive these results by extending the k-party generalization in [CA08, LS08] of the pattern matrix method of Sherstov [She07, She08]. Using this technique, we derive a new sufficient criterion for strong communication complexity lower bounds based on functions having many diverse subfunctions that do not have good low-degree polynomial approximations. This criterion guarantees that such functions have orthogonalizing distributions that are “max-smooth” as opposed to the “min-smooth” orthogonalizing distributions used by Razborov and Sherstov [RS08] to analyze the sign-rank of AC 0 .
An Active Learning Algorithm for Ranking from Pairwise Preferences with an Almost Optimal Query Complexity

Given a set V of n elements we wish to linearly order them given pairwise preference labels which may be non-transitive (due to irrationality or arbitrary noise). The goal is to linearly order the elements while disagreeing with as few pairwise preference labels as possible. Our performance is measured by two parameters: The number of disagreements (loss) and the query complexity (number of pairwise preference labels). Our algorithm adaptively queries at most O(e-6n log5 n) preference labels for a regret of e times the optimal loss. As a function of n, this is asymptotically better than standard (non-adaptive) learning bounds achievable for the same problem. Our main result takes us a step closer toward settling an open problem posed by learning-to-rank (from pairwise information) theoreticians and practitioners: What is a provably correct way to sample preference labels? To further show the power and practicality of our solution, we analyze a typical test case in which a large margin linear relaxation is used for efficiently solving the simpler learning problems in our decomposition.
Mapping the everyday life information needs of Catholic clergy: Savolainen's ELIS model revisited

Purpose – The purpose of this paper is to describe the pattern of everyday life information needs of a group of people in an area with limited access to information, and to investigate how the major dimensions of the everyday life information seeking (ELIS) model apply to information needs in the contexts of the Catholic clergy. Design/methodology/approach – The study applied the concurrent triangulation strategy of mixed-methods research. Data from 15 episodic interviews and surveys of 109 Catholic clergy in Northern Nigeria were collected and analyzed. Findings – A map of the everyday life information needs was developed. Three types of everyday life information needs were identified: essential needs; circumstantial needs; and occasional needs. The information needs of these clergy did not fit into the two major dimensions of Savolainen’s ELIS model. Research limitations/implications – The study was conducted only with Catholic clergy serving in the Northern Catholic dioceses of Nigeria. Originality/val.
Optimising the Fuzzy Granulation of Attribute Domains

The definitions of the number of fuzzy sets and their proper distribution on their domains are fundamental issues for fuzzy systems since these basic parameters deeply affect the quality of the systems results, both in terms of performance rates and interpretabil- ity. Several methods have been proposed in the literature to define these parameters, although it is common to find works in which the number of fuzzy sets is defined empirically, distributing them equally in the domains. This paper presents a fast and easy method to esti- mate the number of fuzzy sets for each attribute and compares three methods for the distribution of fuzzy sets. Two of them are non- supervised methods, using same width and same frequency, the third one is an adaptation of the 1-R supervised method to discretize at- tributes. Experiments with 10 datasets for classification problems, 10-fold cross validation, using the Wang & Mendel method, and the classic and general fuzzy reasoning methods are presented and dis- cussed.
ACE: A Novel Software Platform to Ensure the Integrity of Long Term Archives

We develop a new methodology to address the integrity of long term archives using rigorous cryptographic techniques. A prototype system called ACE (Auditing Control Environment) was designed and developed based on this methodology. ACE creates a small-size integrity token for each digital object and some cryptographic summary information based on all the objects handled within a dynamic time period. ACE continuously audits the contents of the various objects according to the policy set by the archive, and provides mechanisms for an independent third-party auditor to certify the integrity of any object. In fact, our approach will allow an independent auditor to verify the integrity of every version of an archived digital object as well as link the current version to the original form of the object when it was ingested into the archive. We show that ACE is very cost effective and scalable while making no assumptions about the archive architecture. We include in this paper some preliminary results on the validation and performance of ACE on a large image collection.
A Heuristic for Hybrid Planning with Preferences

In this paper, we introduce an admissible heuristic for hybrid planning with preferences. Hybrid planning is the fusion of hierarchical task network (HTN) planning with partial order causal link (POCL) planning. We consider preferences to be soft goals — facts one would like to see satisfied in a goal state, but which do not have to hold necessarily. Our heuristic estimates the best quality of any solution that can be developed from the current plan under consideration. It can thus be used by any branch-and-bound algorithm that performs search in the space of plans to prune suboptimal plans from the search space.
Comparing 3 T and 1.5 T MRI for tracking Alzheimer's disease progression with tensor‐based morphometry

A key question in designing MRI‐based clinical trials is how the main magnetic field strength of the scanner affects the power to detect disease effects. In 110 subjects scanned longitudinally at both 3.0 and 1.5 T, including 24 patients with Alzheimer's Disease (AD) [74.8 ± 9.2 years, MMSE: 22.6 ± 2.0 at baseline], 51 individuals with mild cognitive impairment (MCI) [74.1 ± 8.0 years, MMSE: 26.6 ± 2.0], and 35 controls [75.9 ± 4.6 years, MMSE: 29.3 ± 0.8], we assessed whether higher‐field MR imaging offers higher or lower power to detect longitudinal changes in the brain, using tensor‐based morphometry (TBM) to reveal the location of progressive atrophy. As expected, at both field strengths, progressive atrophy was widespread in AD and more spatially restricted in MCI. Power analysis revealed that, to detect a 25% slowing of atrophy (with 80% power), 37 AD and 108 MCI subjects would be needed at 1.5 T versus 49 AD and 166 MCI subjects at 3 T; however, the increased power at 1.5 T was not statistically significant (α = 0.05) either for TBM, or for SIENA, a related method for computing volume loss rates. Analysis of cumulative distribution functions and false discovery rates showed that, at both field strengths, temporal lobe atrophy rates were correlated with interval decline in Alzheimer's Disease Assessment Scale‐cognitive subscale (ADAS‐cog), mini‐mental status exam (MMSE), and Clinical Dementia Rating sum‐of‐boxes (CDR‐SB) scores. Overall, 1.5 and 3 T scans did not significantly differ in their power to detect neurodegenerative changes over a year. Hum Brain Mapp, 2010. © 2009 Wiley‐Liss, Inc.
Analysis and Synthesis of Memory-Based Fuzzy Sliding Mode Controllers

This paper addresses the sliding mode control problem for a class of Takagi-Sugeno fuzzy systems with matched uncertainties. Different from the conventional memoryless sliding surface, a memory-based sliding surface is proposed which consists of not only the current state but also the delayed state. Both robust and adaptive fuzzy sliding mode controllers are designed based on the proposed memory-based sliding surface. It is shown that the sliding surface can be reached and the closed-loop control system is asymptotically stable. Furthermore, to reduce the chattering, some continuous sliding mode controllers are also presented. Finally, the ball and beam system is used to illustrate the advantages and effectiveness of the proposed approaches. It can be seen that, with the proposed control approaches, not only can the stability be guaranteed, but also its transient performance can be improved significantly.
Biomechanical Comparison of Sacral Fixation Characteristics of Standard S1-Pedicle Screw Fixation versus a Novel Constrained S1-Dual-Screw Anchorage in the S1-Pedicle and S1-Alar Bone

Study Design. Biomechanical Laboratory Study. Objective. Analysis of the biomechanical characteristics of a novel sacral constrained dual-screw fixation device (S1-PALA), combining a S1-pedicle screw and a S1-ala screw, compared to a standard bicortical S1-pedicle screw (S1-PS) fixation. Summary of Background Data. Instrumented fusions to the sacrum are biomechanically challenging and plagued by a high risk of nonunion when S1-PS is used as the sole means of fixation. Thus, lumbopelvic fixation is increasingly selected instead, although associated with a reasonable number of instrumentation-related complications. Methods. Around 30 fresh-frozen human sacral bones were harvested and embedded after CT scans. Instrumentation was conducted in alternating order with bicortical 7.0 mm S1-PS and with the S1-PALA including a S1-PS screw and a S1-ala screw, of 7.0 and 6.0 mm diameter, respectively. Specimens were subjected to cyclic loading with increasing loads (25–250 N) until a maximum of 2000 cycles or displacement >2 mm occurred. All implant sacral units (ISUs) were subject to coaxial pullout tests. Failure load, number of ISUs surpassing 2000 cycles, number of cycles, and loads at failure were recorded and compared. Results. Donors’ age averaged 77 ± 14.2 years, and BMD was 115 ± 64.8 mgCA-HA/ml. Total working length of screws implanted was 90 ± 8.6 mm in the S1-PALA group and 46 ± 5 mm in the S1-PS group (P = 0.0002). In the S1-PALA group, displacement >2 mm occurred after 845 ± 325 cycles at 149 ± 41 N compared to 512 ± 281 cycles at 106 ± 36 N in the S1-PS group (P = 0.004; P = 0.002). In coaxial pull-out testing, failure load was 2118.1 ± 1166 N at a displacement of 2.5 ± 1 mm in the S1-PALA group compared to 1375.6 ± 750.1 N at a displacement of 1.6 ± 0.5 mm in the S1-PS group (P = 0.0007; P = 0.0003). Conclusion. The novel sacral constrained dual-screw anchorage (S1-PALA) significantly improved holding strength after cyclic loading compared to S1-PS. The S1-PALA demonstrated mechanical potential as a useful adjunct in the armamentarium of lumbosacral fixations indicated in cases that need advanced construct stability, but where instrumentation to the ilium or distal dissection to S2 should be avoided. Level of Evidence: N/A
Dynamics of Collective Multi-stability in Models of Multi-Unit neuronal Systems

In this study, we investigate the correspondence between dynamic patterns of behavior in two types of computational models of neuronal activity. The first model type is the realistic neuronal model; the second model type is the phenomenological or analytical model. In the simplest model set-up of two interconnected units, we define a parameter space for both types of systems where their behavior is similar. Next we expand the analytical model to two sets of 90 fully interconnected units with some overlap, which can display multi-stable behavior. This system can be in three classes of states: (i) a class consisting of a single resting state, where all units of a set are in steady state, (ii) a class consisting of multiple preserving states, where subsets of the units of a set participate in limit cycle, and (iii) a class consisting of a single saturated state, where all units of a set are recruited in a global limit cycle. In the third and final part of the work, we demonstrate that phase synchronization of units can be detected by a single output unit.
Clinical analysis of infarction in pituitary adenoma.

OBJECTIVES This study is to summarize the clinical manifestations, imaging findings, treatment and prognosis of pituitary apoplexy caused by ischemic infarction. METHODS From January 2010 to March 2014, 412 patients with pituitary adenoma were admitted in the Department of Neurosurgery at Fuzhou General Hospital, with 9 cases being diagnosed with ischemic infarction stroke. Imaging examinations were performed, including computed tomography and magnetic resonance imaging. Pituitary adenomas were evaluated according to suprasellar, infrasellar, parasellar, anterior and posterior classification. Hematoxylin and eosin staining and immunohistochemical staining were used for identifying pituitary adenoma. RESULTS Tumor height was 1.3-3.3 cm, with an average of 2.27 cm. Eight patients had typical clinical stroke symptoms. Preoperatively, high blood growth hormone concentration was presented in 6 cases, full hypopituitarism in 2 cases, dysfunction of corticosteroids and gonads in 4 cases, and single gonadal dysfunction in 2 cases. Ring enhancement was presented in 8 cases on constructed computed tomography or magnetic resonance images, and sellar settlement in 7 cases. Eight patients were conducted with transsphenoidal resection, and secondary transsphenoidal after craniotomy in 1 case. During surgery, poor tumor blood supply was found in 7 cases, cheese-like or tofu-like necrotic tissues in 5 cases, and few dark blood clots in 2 cases. CONCLUSIONS Pituitary ischemic infarction stroke is clinically rare, but can be correctly diagnosed before surgery by imaging examinations. The pathological characteristics of the tumor are necrosis and fibrosis, which are easy for resection. Therefore, pituitary adenoma usually has good prognosis.