Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of Air Displacement Plethysmography in the Determination of Percentage of Fat Mass in African American Children

The purpose of this study was to determine the ability of air displacement plethysmography (ADP) to estimate percentage of fat mass (%FM) in African American children. %FM was determined in 21 boys and 13 girls (11.0 ± 1.4 y, 18.6 ± 4.2 kg/m2 [mean ± SD]) by ADP (using six published densitometric equations) and dual-energy x-ray absorptiometry (DXA). Measures were done within 2 h of one another, in random order. Regardless of equation, %FMADP was significantly correlated with %FMDXA (R2 = 0.67–0.71, all p < 0.001). %FMADP using the equation of Siri (%FMADP-Siri 20.3 ± 9.0) agreed most closely with %FMDXA (20.0 ± 10.2, difference p = 0.729). Together, surface area artifact and bone mineral content per unit of bonefree fat-free mass accounted for 29% of the variance in the residual between methods. The correlation between %FMADP-Siri and %FMDXA was not significant for those <35 kg (n = 10; R2 = 0.084, p = 0.417). There was a trend toward %FMADP-Siri underestimating %FMDXA in girls (−1.46 ± 3.0%FM; p = 0.103) but not in boys (1.43 ± 6.4%FM; p = 0.315). Predicted lung volume was 40.1% higher than measured lung volume (p < 0.001). %FMADP-Siri determined using predicted lung volume was 23.5 ± 8.9, higher than that using measured lung volume (p = 0.001) and higher than %FMDXA (p = 0.001). We conclude that in 9- to 14-y-old African American children and provided lung volume is measured, %FM using ADP with Siri's equation approximates that obtained by DXA. Body composition results determined by ADP in children <35 kg should be interpreted with caution.
Discrepancies in estimates of prevalence and correlates of substance use and disorders between two national surveys.

AIM To assess the degree to which methodological differences might influence estimates of prevalence and correlates of substance use and disorders by comparing results from two recent surveys administered to nationally representative US samples. METHODS Post-hoc comparison of data from the 2002 National Survey on Drug Use and Health (NSDUH) with data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) administered in 2001-02. RESULTS Prevalence estimates for all substance use outcomes were higher in the NSDUH than in the NESARC; ratios of NSDUH to NESARC prevalences ranged from 2.1 to 5.7 for illegal drug use outcomes. In the NSDUH, past-year substance use disorder (SUD) prevalence estimates were higher for cocaine and heroin, but were similar to NESARC estimates for alcohol, marijuana and hallucinogens. However, prevalence estimates for past-year SUD conditional on past-year use were substantially lower in the NSDUH for marijuana, hallucinogens and cocaine. Associations among drug and SUD outcomes were substantially higher in the NESARC. Total SUD prevalence did not differ between surveys, but estimates for blacks and Hispanics were higher in the NSDUH. CONCLUSION A number of methodological variables might have contributed to such discrepancies; among plausible candidates are factors related to privacy and anonymity, which may have resulted in higher use estimates in the NSDUH, and differences in SUD diagnostic instrumentation, which may have resulted in higher SUD prevalence among past-year substance users in the NESARC.
Isolation of “Candidatus Rickettsia andeanae” (Rickettsiales: Rickettsiaceae) in Embryonic Cells of Naturally Infected Amblyomma maculatum (Ixodida: Ixodidae)

ABSTRACT The Gulf Coast tick, Amblyomma maculatum Koch, has become increasingly important in public health for its role as a vector of the recently recognized human pathogen, Rickettsia parkeri. More recently, these ticks were also found to harbor a novel spotted fever group rickettsia, “Candidatus Rickettsia andeanae. ” First identified in Peru, and subsequently reported in ticks collected in the United States, Chile, and Argentina, “Ca. R. andeanae” remains largely uncharacterized, in part because of the lack of a stable isolate. Although the isolation of “Ca, R. andeanae” was recently described in DH82, Vero, and Drosophila S2 cells, its stability in these cell lines was not shown. To evaluate “Ca. R. andeanae” transmission and pathogenicity in vertebrates, as well as further describe biological characteristics of this candidate species to fulfill criteria for its establishment as a new species, availability of a stable isolate is essential. Here we describe the propagation of “Ca. R. andeanae” by using a primary culture derived from naturally infected A. maculatum embryos. Subsequent passage of the “Ca. R. andeanae” isolate to ISE6 (Ixodes scapularis embryonic) and Vero (African green monkey kidney epithelial) cell lines demonstrated limited propagation of the rickettsiae. Treatment of the infected primary cells with tetracycline resulted in cultures negative for “Ca. R. andeanae” by polymerase chain reaction and microscopy. Establishment of an isolate of “Ca. R. andeanae” will promote further investigation into the significance of this tick-associated rickettsia, including its role in spotted fever and interactions with the sympatric species, R. parkeri in A. maculatum.
3‐dimensional functional imaging of human brain using echo‐shifted FLASH MRI

A 3‐dimensional MRI method has been developed for functional mapping of the human brain, based on blood oxygenation level dependent (BOLD) contrast mechanisms. The method uses recently introduced principles of echo‐shifted FLASH to acquire a single 3D data set in 20 s. The technique was tested on a conventional 1.5 Tesla clinical scanner with a standard head coil using visual stimulation with a 8 Hz flashing white light, or a varying checkerboard pattern. Areas of increased signal intensity were identified in the visual cortex, consistent with the known functional organization.
A Supply‐Side Analysis of Agritourism: Evidence from Farm‐Level Agriculture Census Data in Taiwan

Due to consumers’ increased demand for leisure and farmers’ need for income diversification, researchers and policymakers have significant interest in topics related to agritourism. This study provides a supply‐side analysis on agritourism using Taiwan as a case study. Utilising a sample of 720,148 family farms from the 2010 agriculture census survey in Taiwan, we quantify the effects of engaging in the agritourism business on farm income, on farm succession, and on family members’ labour supply decisions between on‐farm and off‐farm work. An analytical framework that combines the doubly robustness regression model and semiparametric estimation is proposed to address the endogeneity bias. Results indicate that participation in agritourism increases farm income and family farm succession. Farms engaging in agritourism also have more family members working on the farm, and fewer family members working off‐farm, compared to farms not engaging in agritourism. Although agritourism enterprises are developed to meet consumers’ demand for leisure, our results show that they also improve the economic welfare of farm households.
The Application of the International Classification of Functioning, Disability and Health to Functional Auditory Consequences of Mild Traumatic Brain Injury

Abstract This article reviews the auditory consequences of mild traumatic brain injury (mTBI) within the context of the International Classification of Functioning, Disability and Health (ICF). Because of growing awareness of mTBI as a public health concern and the diverse and heterogeneous nature of the individual consequences, it is important to provide audiologists and other health care providers with a better understanding of potential implications in the assessment of levels of function and disability for individual interdisciplinary remediation planning. In consideration of body structures and function, the mechanisms of injury that may result in peripheral or central auditory dysfunction in mTBI are reviewed, along with a broader scope of effects of injury to the brain. The activity limitations and participation restrictions that may affect assessment and management in the context of an individual's personal factors and their environment are considered. Finally, a review of management strategies for mTBI from an audiological perspective as part of a multidisciplinary team is included.
Changes in Vegetation Greenness in the Upper and Middle Reaches of the Yellow River Basin over 2000–2015

The Grain to Green Project (GTGP), a large ecological restoration project aiming to control soil erosion and improve the ecological environment, has been implemented since 1999 and has led to great land use changes with decreased farmland and increased forest and grass, and significant vegetation variations. Understanding vegetation variations for different land use types is important for accessing the present vegetation development and providing scientific guidance for future ecological restoration design and regional sustainable development. With two land use maps and MODIS LAI data, trend analysis, fluctuation analysis, and R/S methods were applied to analyze the vegetation dynamic changes and sustainability for converted land use types from cropland and unconverted types over 2000–2015 in the upper and middle reaches of the Yellow River. The results obtained were as follows: (1) Vegetation greening was remarkable in the entire study region (0.036 yr−1). The increasing rate was higher in wetter conditions with AI < 3 (0.036–0.053 yr−1) than arid regions with AI > 3 (0.012–0.024 yr−1). (2) Vegetation improved faster for converted forestland, shrubland, and grassland than unconverted types under similar drying conditions. Converted shrubland and grassland had a larger relative change than converted forestland. (3) Converted land use types generally exhibited stronger fluctuation than unconverted types with small differences among types. (4) Vegetation exhibited a sustainable increasing trend in the future, which accounted for more than 73.1% of the region, mainly distributed in the middle reach of the Yellow River. Vegetation restoration exerted important influences on vegetation greening and the effect was stronger for converted types than unconverted types.
MUC5AC and MUC5B enhance the characterization of mucinous adenocarcinomas of the lung and predict poor prognosis

From the viewpoint of histogenesis, lung adenocarcinoma can be subdivided into two groups: terminal respiratory unit (TRU) and non‐TRU types. We recently reported a non‐TRU type adenocarcinoma designated as ciliated adenocarcinoma (we now prefer central type adenocarcinoma). We suggest reasons that mucinous adenocarcinoma should encompass central type adenocarcinoma to represent its biological characteristics as non‐TRU type adenocarcinoma.
Establishing a New Index of Muscle Cross-Sectional Area and its Relationship With Isometric Muscle Strength

The present study aimed i) to establish an index of muscle cross-sectional area (CSA) based on muscle thickness and circumference through a comparison with muscle CSA determined by magnetic resonance imaging (MRI), and ii) to examine the relationships between muscle strength and the index determined at rest and during the maximal isometric contraction. The muscle CSA of elbow flexors at 60% of the upper arm length (CSA60) and the maximal CSA of elbow flexors (CSAmax) were measured using MRI in 26 men and 8 women. The muscle thickness (MT) of elbow flexors and the circumference (C) of upper arm at 60% of the upper arm length were measured using ultrasonography and anthropometry, respectively, in 29 men and 9 women. The measurements of MT and C were performed in the resting (MTr and Cr) and contracted condition (MTm and Cm), where the subjects performed maximal voluntary contraction (MVC) of isometric elbow joint flexion. The torque developed during MVC was converted into the muscle force (F) of elbow flexors. The MTr × Cr was significantly correlated both with CSA60 and CSAmax (P < 0.001). The F was significantly correlated with MTm × Cm (r = 0.847, P < 0.001) and MTr × Cr (r = 0.839, P < 0.001). However, stepwise multiple regression analysis selected only MTm × Cm as a significant contributor for estimating F. The present study indicates that MT × C reflects muscle CSA, and can be an index for assessing muscle CSA. In addition, the findings obtained here showed a possibility that MT × C during MVC is more closely related to F than that at rest.
Sensory stimuli in gaming interaction: The potential of games in the intervention for children with cerebral palsy

One of the challenges that children with cerebral palsy (CP) face is their inability to enjoy playing. Due to their motor disabilities, it is very difficult for these children to play with toys as other kids do. Therefore, disabilities resulting from CP can make childhood games very burdensome. Currently, computer systems are increasingly dedicated to providing users with more sophisticated sensory experiences. Also, games have explored the individual skills of people, in terms of action, interaction and immersion of the game users. Providing these disabled users with an engaging environment could ultimately help them explore the world of movement and motor skills. In this paper, we approach these features by exploring gaming interaction and the potential of sensory stimuli. Our main goal is to discuss the importance of designing games that are considerate of children with cerebral palsy. Many games work with interactivity, but interactivity, alone, is not enough when the goal is to achieve more than entertainment. A better approach may consider sensory stimulation as a gaming interaction. The best way to do this is to introduce synesthesia into the design. Accordingly, we will discuss synesthetic features in virtual environments prior to describing the scenario of how this concept may affect children with cerebral palsy. Accompanying this discussion, a review of related works is described in order to understand the potential use of games in the intervention of children with cerebral palsy.
Hyperdimensional computing with 3D VRRAM in-memory kernels: Device-architecture co-design for energy-efficient, error-resilient language recognition

The ability to learn from few examples, known as one-shot learning, is a hallmark of human cognition. Hyperdimensional (HD) computing is a brain-inspired computational framework capable of one-shot learning, using random binary vectors with high dimensionality. Device-architecture co-design of HD cognitive computing systems using 3D VRRAM/CMOS is presented for language recognition. Multiplication-addition-permutation (MAP), the central operations of HD computing, are experimentally demonstrated on 4-layer 3D VRRAM/FinFET as non-volatile in-memory MAP kernels. Extensive cycle-to-cycle (up to 1012 cycles) and wafer-level device-to-device (256 RRAMs) experiments are performed to validate reproducibility and robustness. For 28-nm node, the 3D in-memory architecture reduces total energy consumption by 52.2% with 412 times less area compared with LP digital design (using registers as memory), owing to the energy-efficient VRRAM MAP kernels and dense connectivity. Meanwhile, the system trained with 21 samples texts achieves 90.4% accuracy recognizing 21 European languages on 21,000 test sentences. Hard-error analysis shows the HD architecture is amazingly resilient to RRAM endurance failures, making the use of various types of RRAMs/CBRAMs (1k ∼ 10M endurance) feasible.
Isolation and identification of phase I metabolites of butyrolactone I in rats

Abstract 1. Butyrolactone I (BL-I), one of the major secondary metabolites of fungus Aspergillus terreus, is a selective cdc2 kinase inhibitor. In the present study, the metabolism of BL-I in male Wistar rats was investigated by characterizing metabolites excreted into feces. 2. Following an oral dose of 40 mg/kg BL-I, 10 phase I metabolites were isolated from the feces of rats, and their structures were identified on the basis of a range of spectroscopic data and ICD analysis. These metabolites were fully characterized as butyrolactone VI (M1), aspernolide E (M2), 7′′S-hydroxy-9′′-ene-butyrolactone I (M3), 7′′R-hydroxy-9′′-ene-butyrolactone I (M4), 7″S, 8″R-dihydroxy-aspernolide E (M5), 7″R, 8″S-dihydroxy-aspernolide E (M6), 7″R-acetyl-8″S-hydroxy-aspernolide E (M7), 7″S-acetyl-8″R-hydroxy-aspernolide E (M8), 7″R-methoxy-8″S-hydroxy-aspernolide E (M9), butyrolactone V (M10), respectively. It is the first time to describe the metabolites of BL-I in vivo, and metabolites M3 to M9 are new compounds. 3. BL-I and metabolites M2 to M10 were evaluated for their antimicrobial activity and in vitro antiproliferative activities. Only M-3 and M-4 showed inhibitory effect against staphylococcus aureus both with MIC of 125 μg/ml. BL-I and metabolites M-4 and M-5 exhibited potent cancer cell growth inhibitory activities against HL-60 (human leukemia) cell lines with the IC50 values of 13.2, 28.8 and 35.7 μM, respectively. 4. On the basis of metabolites profile, a possible metabolism pathway for BL-I in rats has been proposed. This is the first systematic study on the phase I metabolites of BL-I.
Substrate integrated waveguide dual-mode dual-band filter with multilayered configuration

A compact substrate integrated waveguide (SIW) dual-mode dual-band bandpass filter (DM-DBBPF) is presented based on two-layer stacked configuration. TE101 and TE201 modes in SIW rectangular cavities are exploited to construct the respective first and second passbands, and the two bandwidths could also be realized over a wide range of ratio by applying the design parameters ratio technique. Thanks to multilayered structure, the footprint of the filter has been reduced about 33% compared to our previous similar work. A prototype operating at 12 and 17 GHz with the fractional bandwidth ratio of 0.77 is designed, fabricated, and tested for demonstration, showing good agreements between the simulated and measured results.
Reciprocity, coupling and scattering: A new look at SPM for rough surface

In this paper, following an intrinsically-reciprocal approach we demonstrate how to straightforwardly derive the classical SPM scattering solution for a rough surface in a surprisingly simple way. The proposed new mathematical formulation for the relevant scattering problem then results, with respect to the classical one, neater, more concise, clearer, and as such offers a more direct comprehension in a methodological perspective. The mathematical structure presented not only represents a conceptually clean formulation for the classical SPM, but itself provides a new way of thinking about the perturbation theory applied to the scattering problem, especially in view of future developments.
Identification of CYP isozymes involved in benzbromarone metabolism in human liver microsomes

Benzbromarone (BBR) is metabolized to 1′‐hydroxy BBR and 6‐hydroxy BBR in the liver. 6‐Hydroxy BBR is further metabolized to 5,6‐dihydroxy BBR. The aim of this study was to identify the CYP isozymes involved in the metabolism of BBR to 1′‐hydroxy BBR and 6‐hydroxy BBR and in the metabolism of 6‐hydroxy BBR to 5,6‐dihydroxy BBR in human liver microsomes. Among 11 recombinant P450 isozymes examined, CYP3A4 showed the highest formation rate of 1′‐hydroxy BBR. The formation rate of 1′‐hydroxy BBR significantly correlated with testosterone 6β‐hydroxylation activity in a panel of 12 human liver microsomes. The formation of 1′‐hydroxy BBR was completely inhibited by ketoconazole in pooled human liver microsomes. On the other hand, the highest formation rate of 6‐hydroxy BBR was found in recombinant CYP2C9. The highest correlation was observed between the formation rate of 6‐hydroxy BBR and diclofenac 4′‐hydroxylation activity in 12 human liver microsomes. The formation of 6‐hydroxy BBR was inhibited by tienilic acid in pooled human liver microsomes. The formation of 5,6‐dihydroxy BBR from 6‐hydroxy BBR was catalysed by recombinant CYP2C9 and CYP1A2. The formation rate of 5,6‐dihydroxy BBR was significantly correlated with diclofenac 4′‐hydroxylation activity and phenacetin O‐deethylation activity in 12 human liver microsomes. The formation of 5,6‐dihydroxy BBR was inhibited with either tienilic acid or α‐naphthoflavone in human liver microsomes. These results suggest that (i) the formation of 1′‐hydroxy BBR and 6‐hydroxy BBR is mainly catalysed by CYP3A4 and CYP2C9, respectively, and (ii) the formation of 5,6‐dihydroxy BBR is catalysed by CYP2C9 and CYP1A2 in human liver microsomes. Copyright © 2012 John Wiley & Sons, Ltd.
Characteristics of CD14 shedding from human monocytes: Evidence for the competition of soluble CD14 (sCD14) with CD14 receptors for lipopolysaccharide (LPS) binding

The accumulation of sCD14 shed from human monocytes in vivo might correlate with other inflammatory parameters and could be of importance in overcoming a sepsis situation. The development of the sCD14 titer in the supernatant of monocyte‐enriched MNC cultures isolated from healthy volunteers was studied utilizing a commercially available sCD14 ELISA. These culture experiments revealed the prolonged liberation of sCD14 into the supernatant during a period of several days. A medium‐exchange schedule of 2–3 days was found to be superior to a longer incubation period with respect to the sCD14 yield. PMA initially enhanced the CD14 shedding slightly, but after a few hours it strongly repressed the process. Such a reduction was also achieved by protein synthesis inhibitors (cycloheximide, actinomycin D). Additionally, we monitored the concentration of sCD14, CRP, IL‐6 and IL‐8 in human sera from healthy persons or patients suffering from severe burn injuries with or without sepsis. Our results indicate that sCD14 is strongly correlated with IL‐6, but not with IL‐8. sCD14 titers were higher in the group of patients with both burn injuries and sepsis. From experiments with monocyte‐enriched MNC cultures isolated from healthy volunteers and medium supplemented with sera containing sCD14 as well as radiolabeled LPS, we conclude that the enhanced shedding of CD14 in vivo during sepsis is probably not able to reduce the binding of LPS to monocytes.
Unequal access and unmet need: neurotic disorders and the use of primary care services

In this paper we use data from the National Survey of Psychiatric Morbidity to examine how many people with neurotic disorders receive professional evaluation, and how this is affected by clinical and sociodemographic differences. We hypothesized that psychiatric symptoms and attendant dysfunctions would both have an effect on contacting, and that key demographic variables would not. The household component of the British National Surveys of Psychiatric Morbidity was based on a random sample of >10,000 subjects. Lay interviewers using the CIS-R established psychiatric symptoms and ICD-10 diagnosis. Social dysfunction was tapped by asking about difficulties in performing seven types of everyday activity. We examined symptom score, ADL deficit score, and demographic variables in relation to contact with primary care physicians for psychiatric symptoms. The major determinant of contacting a primary care physician was severity, mainly due to the level of psychiatric symptoms, but with an independent contribution from social dysfunction. There were also significant contributions from sex, marital status, age, employment status, and whether the subject had a physical condition as well. The major influence on whether people seek the help of their family doctors for mental health problems is the severity of disorder. Although there are some social inequalities in access to family doctors, these are less important. The most salient finding from our study is that even people suffering from high levels of psychiatric symptoms very often do not have contact with professionals who might help them.