Miracle-dz/UniFAR-FTUs huggingface dataset:
Collaborative complementation study of temperature-sensitive mutants of herpes simplex virus types 1 and 2

Twenty-three complementation groups of herpes simplex virus type 1 (HSV-1) and 20 of HSV-2 were identified by qualitative and quantitative complementation analysis from among 43 temperature-sensitive (ts) mutants of HSV-1 and 29 ts mutants of HSV-2 which had been isolated independently in 10 laboratories.
Para além e aquém de anjos, loucos ou demônios: CAPS e Pentecostalismo em análise

800x600 Este estudo coloca em analise modos de subjetivacao da loucura, atraves das experiencias dos usuarios de um CAPS, nas religioes pentecostais, identificando possiveis articulacoes entre estas instituicoes. Trata-se de um estudo qualitativo, com o referencial da Analise Institucional e da Etnografia, realizado com quatro usuarios filiados as igrejas pentecostais, seus familiares e equipe tecnica do CAPS. Acredita-se que a relacao entre o CAPS e a religiao, se situa num campo de forcas, enquanto modos de produzir saberes e fazeres sobre a loucura, sobre e com o louco. Esta tensao parece se acentuar na relacao com determinadas religioes, como as pentecostais, que concebem a loucura como possessao demoniaca, mobilizando rituais de exorcismo. Paradoxalmente, se constatou a existencia de uma logica manicomial que perpassa as instituicoes, que produz subjetividades manicomiais, assim como se constatou que essas instituicoes tambem promovem inclusao social e producao de novos sentidos para a experiencia da loucura. Normal 0 21 false false false PT-BR X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:. 0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";}
Western Linguistics: An Historical Introduction

Preface. Acknowledgements. Part 1 1. Linguistics from Antiquity till the Seventeenth-Century. 2. The Eighteenth and Nineteenth-Centuries. 3. The Twentieth-Century: Europe. 4. The Twentieth-Century: America. Part 2 5. Predicate Calculus: from Aristotle to Generalized Quantifiers. 6. The Study of Meaning. 7. Meaning and Grammar. Bibliography. Index.
Mapping Libya’s prostate cancer based on the SMR method:a geographical analysis

Disease mapping has become an important method used in public health research and disease epidemiology. It is a spatial representation of epidemiology data. A very common disease mapping method is called Standardized Morbidity Ratio (SMR). Many researchers used this method to estimate the relative risk of the disease as a preliminary analysis. In this study, the SMR method displays the high and low risk areas of prostate cancer for all districts in Libya. SMR is the ratio of the observed to the expected number of prostate cancer cases and was applied to the observed prostate cancer data from Libya for the years 2010 and 2011. The results were presented in graphs and maps. The highest risk of prostate cancer (all type of cancers) is in the West of Libya probably due to the oil installations in this area such as Mellitah Oil and Gas B.v, the Azawia Oil Refining Company and Bouri Oil Field, as well as the electrical power stations. Susceptible people located in the Eastern part of the country have the lowest risk when compared to the overall population. In conclusion the results show that the use of the SMR method to estimate the relative risk in maps provides high-low risk appearances in maps compared to using the total number of cancer incidence alone. In other words, the SMR method can be considered a basic procedure because it takes into account the total human population for each district. Keywords: disease mapping, Libya, prostate cancer, relative risk, spatial analysis, Standardized Morbidity Ratio
The Fast Neutron Imaging Telescope (FNIT) - hardware development and prototype testing

We describe the design and performance of a prototype instrument with capabilities for both imaging and spectroscopy of sources of 1-10 MeV neutrons. The laboratory prototype is composed of custom-designed liquid scintillator detectors and employs measurements of double neutron-proton scattering to determine the direction and energy of incident neutrons. The detectors provide measurements of the position, energy deposit and pulse shape for each interaction. Pulse shape discrimination and a time-of-flight measurement between coincident interactions in two detectors are used to identify the neutron events, reject background due to Compton scattered gamma radiation and provide a measure of the scattered neutron energy. Calculations employing double n-p scattering kinematics are used to accumulate images and spectra of the neutron source. The quality of these images and spectra is correlated with the energy, position and timing resolution of the detectors. The prototype instrument achieves ~5deg angular resolution and 20% energy resolution (1sigma). This paper presents the design and the most recent results.
A moving window architecture for a HW/SW codesign based Canny edge detection for FPGA

This paper proposes an accelerator for Canny edge detection implemented on FPGA. The proposed architecture relies on a moving window consisting of 7×8 pixels, which performs the more computational complex operations of the algorithm: smoothing, gradient's magnitude and direction computation, non-maximum suppression and double thresholding. By employing the proposed window, intermediate results are stored within the FPGA, without the need to buffer them in large memory structures. Furthermore, the design has a high throughput rate, due to its large numbers of pipeline stages, allowing considerable performance for the proposed algorithm.
The register-based system of demographic and social statistics in Denmark.

"Denmark has developed a statistical system where a large portion of official statistics is based on administrative registers. Population and Housing Censuses have been replaced by register based statistics since 1981. The key of the system is the unique Person Number used in all public administrations. A large number of registers is used as sources and is linked together in order to compile the best estimates of the statistical concepts. This allows for high quality statistics that are timely, consistent and well-suited for longitudinal studies. Problems of quality may arise from changes in the legislation or in the registers. A strong data protection policy is necessary in order to preserve the system. "
Neuritogenic and survival‐promoting effects of the P2 peptide derived from a homophilic binding site in the neural cell adhesion molecule

The neural cell adhesion molecule (NCAM) plays a pivotal role in neural development, regeneration, and plasticity. NCAM mediates adhesion and subsequent signal transduction through NCAM–NCAM binding. Recently, a peptide ligand termed P2 corresponding to a 12‐amino‐acid sequence in the FG loop of the second Ig domain of NCAM was shown to mimic NCAM homophilic binding as reflected by induction of neurite outgrowth in hippocampal neurons. We demonstrate here that in concentrations between 0.1 and 10 μM, P2 also induced neuritogenesis in primary dopaminergic and cerebellar neurons. Furthermore, it enhanced the survival rate of cerebellar neurons although not of mesencephalic dopaminergic neurons. Moreover, our data indicate that the protective effect of P2 in cerebellar neurons was due to an inhibition of the apoptotic process, in that caspase‐3 activity and the level of DNA fragmentation were lowered by P2. Finally, treatment of neurons with P2 resulted in phosphorylation of the ser/thr kinase Akt. Thus, a small peptide mimicking homophilic NCAM interaction is capable of inducing differentiation as reflected by neurite outgrowth in several neuronal cell types and inhibiting apoptosis in cerebellar granule neurons. © 2003 Wiley‐Liss, Inc.
Utility of Agarose Cell Block Technique for Fine Needle Aspiration, Urine and Serous Effusions Cytology in Gezira State

Objective: To assess utility of the agarose cell block technique based on specimen adequacy and diagnostic accuracy. Material and Methods: 63 study subjects were selected for this study, among them 12(19%) were males and 51(81%) were females with age range between 4-77 years and the mean age was 36.97 ± 1.9. One cell block section and one smear were made from each case, the study cases were divided into 4 groups according to the type of specimens including thyroid 23 (36.5%), breast 15(23.8%), lymph nodes 6 (9.5%) and soft tissue masses 9 (14.28). The rest include three (4.76 %) effusions (Two Ascetic fluids and One pleural fluid), and 7(11.11%) urine samples. The soft tissue masses include face lipoma, post auricular, arm, back, right mandible, foot, ankle, neck, and abdominal masses. Result: When comparing the final diagnosis of cell block sections and cytological smears according to the background, cellularity, the nuclear and cytoplasm preservation, 21(33.3%) of samples were better by cell block technique, 27(42.9%) showed same results in both cellblock technique and smearing technique and 15(23.8%) were found to be less using cell block technique. Conclusion: The study concludes that different cellblock sections should be used for, histochemical, immunohistochemical (IHC), and Immunocytochemical (ICC) investigations in diagnostic cytology laboratories. Molecular studies such as, fluorescent /chromogenic in-situ hybridization (FISH/CISH) and in-situ PCR, could also be applied on cell block sections.
Rationalization of esthetic restorative dentistry based on biomimetics.

UNLABELLED The exponential progressivism that characterizes the current decade often comes with substantial financial implications. Dental care is not spared by this phenomenon. However, new generations of concepts emerging from biomimetics provide the operator with the ability to restore the biomechanical, structural, and esthetic integrity of teeth. The development of adhesion and the evolution of porcelain veneers constitute striking examples of this nascent process. Indications for bonding porcelain are extending to more perilous situations (crown-fractured incisors, nonvital teeth), resulting in considerable improvements, comprising both the medical-biologic aspect (economy of sound tissues and maintenance of tooth vitality) and the socioeconomical context (decrease of costs compared to traditional and more invasive prosthetic treatments). CLINICAL SIGNIFICANCE In the bonded porcelain veneer and its extensions, restorative dentistry has found new solutions for the anterior segment that balance the need for functional and esthetic reconstruction. The optimal stiffness of porcelain in thin section, the ideal surface characteristics, and the biomechanical continuum achieved through high performance bonding mean the crown of the tooth as a whole can support incisal or masticatory function. By the same token, the conduction of optical effects from within the tooth combined with the ideal surface features of the porcelain veneer make this restorative approach the ultimate in esthetic satisfaction, for both the practitioner and the patient.
Mind–body complementary alternative medicine use and quality of life in adolescents with inflammatory bowel disease

Background: Mind–body complementary and alternative medicine (CAM) modalities (e.g., relaxation or meditation) for symptom management have not been well studied in adolescents with inflammatory bowel disease (IBD). The purposes of this study were to: 1) determine the prevalence of 5 types of mind–body CAM use, and consideration of use for symptom management; 2) assess characteristics associated with regular mind–body CAM use; and 3) examine whether regular and/or considered mind–body CAM use are associated with health‐related quality of life (HRQOL). Methods: Sixty‐seven adolescents with IBD ages 12–19 recruited from a children's hospital completed a questionnaire on CAM use and the Pediatric Quality of Life Inventory. Logistic regression models were estimated for regular and considered CAM use. Results: Participants mean (SD) age was 15.5 (2.1) years; 37 (55%) were female; 53 (79%) were white; and 20 (30%) had moderate disease severity. Adolescents used prayer (62%), relaxation (40%), and imagery (21%) once/day to once/week for symptom management. In multivariate analyses, females were more likely to use relaxation (odds ratio [OR] = 4.38, 95% confidence interval [CI] = 1.25–15.29, c statistic = 0.73). Younger adolescents were more likely to regularly use (OR = 0.63, 95% CI = 0.42–0.95, c statistic = 0.72) or consider using (OR = 0.77, 95% CI = 0.59–1.00, c statistic = 0.64) meditation. Adolescents with more severe disease (OR = 4.17, 95% CI = 1.07–16.29, c statistic = 0.83) were more willing to consider using relaxation in the future. Adolescents with worse HRQOL were more willing to consider using prayer and meditation for future symptom management (P < 0.05). Conclusions: Many adolescents with IBD either currently use or would consider using mind–body CAM for symptom management. (Inflamm Bowel Dis 2010)
TNFSF10/TRAIL regulates human T4 effector memory lymphocyte radiosensitivity and predicts radiation-induced acute and subacute dermatitis

Sensitivity of T4 effector-memory (T4EM) lymphocytes to radiation-induced apoptosis shows heritability compatible with a Mendelian mode of transmission. Using gene expression studies and flow cytometry, we show a higher TNF-Related Apoptosis Inducing Ligand (TRAIL/TNFSF10) mRNA level and a higher level of membrane bound TRAIL (mTRAIL) on radiosensitive compared to radioresistant T4EM lymphocytes. Functionally, we show that mTRAIL mediates a pro-apoptotic autocrine signaling after irradiation of T4EM lymphocytes linking mTRAIL expression to T4EM radiosensitivity. Using single marker and multimarker Family-Based Association Testing, we identified 3 SNPs in the TRAIL gene that are significantly associated with T4EM lymphocytes radiosensitivity. Among these 3 SNPs, two are also associated with acute and subacute dermatitis after radiotherapy in breast cancer indicating that T4EM lymphocytes radiosensitivity may be used to predict response to radiotherapy. Altogether, these results show that mTRAIL level regulates the response of T4EM lymphocytes to ionizing radiation and suggest that TRAIL/TNFSF10 genetic variants hold promise as markers of individual radiosensitivity.
Interaction Between the μ Opioid Receptor and Filamin A Is Involved in Receptor Regulation and Trafficking

The carboxyl tail of the human μ opioid receptor was shown to bind the carboxyl terminal region of human filamin A, a protein known to couple membrane proteins to actin. Results from yeast two-hybrid screening were confirmed by direct protein-protein binding and by coimmunoprecipitation of filamin and μ opioid receptor from cell lysates. To investigate the role of filamin A in opioid receptor function and regulation, we used the melanoma cell line M2, which does not express filamin A, and its subclone A7, transfected with human filamin A cDNA. Both cell lines were stably transfected with cDNA encoding myc-tagged human μ opioid receptor. Fluorescent studies, using confocal microscopy, provided evidence that filamin and μ opioid receptors were extensively colocalized on the membranes of filamin-expressing melanoma cells. The immunostaining of μ opioid receptors indicated that the lack of filamin had no detectable effect on membrane localization of the receptors. Moreover, μ opioid receptors function normally in the absence of filamin A, as evidenced by studies of opioid binding and DAMGO inhibition of forskolin-stimulated adenylyl cyclase. However, agonist-induced receptor down-regulation and functional desensitization were virtually abolished in cells lacking filamin A. The level of internalized μ-opioid receptors, after 30-min exposure to agonist, was greatly reduced, suggesting a role for filamin in μ opioid receptor trafficking. During these studies, we observed that forskolin activation of adenylyl cyclase was greatly reduced in filamin-lacking cells. An even more unexpected finding was the ability of long-term treatment with [d-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin of M2 cells, containing μ opioid receptors, to restore normal forskolin activation. The mechanism of this effect is currently unknown. It is postulated that the observed effects on μ opioid receptor regulation by filamin A and, by implication, of the actin cytoskeleton may be the result of its role in μ opioid receptor trafficking.
Vibrio anguillarum as a fish pathogen: virulence factors, diagnosis and prevention.

Vibrio anguillarum, also known as Listonella anguillarum, is the causative agent of vibriosis, a deadly haemorrhagic septicaemic disease affecting various marine and fresh/brackish water fish, bivalves and crustaceans. In both aquaculture and larviculture, this disease is responsible for severe economic losses worldwide. Because of its high morbidity and mortality rates, substantial research has been carried out to elucidate the virulence mechanisms of this pathogen and to develop rapid detection techniques and effective disease-prevention strategies. This review summarizes the current state of knowledge pertaining to V. anguillarum, focusing on pathogenesis, known virulence factors, diagnosis, prevention and treatment.
Diversion colitis — new light through old windows

Diversion proctocolitis is an iatrogenic disorder caused by surgical diversion of the faecal stream away from the colorectal mucosa. Such surgery may be necessary in cases of tumour, trauma or inflammatory conditions of the colorectum. Histopathological change is characterized by a chronic lymphoplasmacytic inflammatory infiltrate, and the hallmark feature, lymphoid follicular hyperplasia. Histological appearances are determined by the disease state of the colonic mucosa prior to faecal diversion. Macroscopic appearances may vary considerably, but often include aphthoid ulceration. The exact pathogenesis of the condition remains unclear, but the removal of short‐chain fatty acids, present in the faecal stream, is considered an important aetiological factor. Current research areas, including the microbiology and cellular kinetics of diversion colitis, are discussed along with clinical features and treatments.
Hardware-in-the-Loop Wind Turbine Simulation Platform for a Laboratory Feeder Model

As part of a larger project to build a laboratory-based smart grid feeder, there was a need to incorporate renewable energy sources into the feeder model. The goal in this project was to create a hardware-in-the-loop (HIL) wind turbine simulation platform. Software is used to calculate a dynamic optimal power point from time-series wind speed data and to generate control signals for the platform's hardware. The hardware consists of a dc motor providing mechanical power to a coupled generator. To validate the HIL simulation platform, time-series wind speed and output power data were used from an installed and operating utility-scale turbine. The steady-state performance of the HIL simulator correlates well with the provided manufacturer's curve, but the dynamic performance of the system is more varied with periods of excellent correlation as well as poor. A richer data set from the utility containing more than wind speed and power output (such as wind direction and turbine yaw position) could provide substantial improvements to the dynamic performance.
TAK1 Inhibition in the DFG‐Out Conformation

The first example of an inhibitor of the kinase TAK1 that binds in the DFG‐out conformation is disclosed. These preliminary studies used kinase‐targeted screening and structure‐based drug design to create a molecule with dual pharmacological inhibition of p38 and TAK1 that demonstrated significant activity in a cell‐based, anti‐inflammatory assay.
Mesh Optimization for Polygonized Isosurfaces

In this paper, we propose a method for improvement of isosurface polygonizations. Given an initial polygonization of an isosurface, we introduce a mesh evolution process initialized by the polygonization. The evolving mesh converges quickly to its limit mesh which provides with a high quality approximation of the isosurface even if the isosurface has sharp features, boundary, complex topology. To analyze how close the evolving mesh approaches its destined isosurface, we introduce error estimators measuring the deviations of the mesh vertices from the isosurface and mesh normals from the isosurface normals. A new technique for mesh editing with isosurfaces is also proposed. In particular, it can be used for creating carving effects.
Mineralocorticoid receptor function in patients with posttraumatic stress disorder.

OBJECTIVE The study examined whether enhanced limbic mineralocorticoid receptor activity resulting in negative glucocorticoid feedback could contribute to the diminished basal and stress-induced cortisol output reported in patients with posttraumatic stress disorder (PTSD). METHOD The effects of acute antimineralocorticoid (spironolactone) versus placebo pretreatment on levels of plasma cortisol at baseline and after stimulations with corticotropin-releasing hormone (CRH) and on adrenocorticotropic hormone (ACTH) level were measured in 12 PTSD patients and 12 healthy comparison subjects. RESULTS Spironolactone significantly elevated basal cortisol and ACTH concentrations as well as cortisol secretion after CRH stimulation, but no differential effect between PTSD patients and comparison subjects was detected. CONCLUSIONS The results indicate intact, but not enhanced, mineralocorticoid receptor function in PTSD. The study's experimental conditions did not allow determination of whether other compensatory factors might have masked the putative mineralocorticoid receptor changes.
Optical conductivity of curved graphene

We compute the optical conductivity for an out-of-plane deformation in graphene using an approach based on solutions of the Dirac equation in curved space. Different examples of periodic deformations along one direction translates into an enhancement of the optical conductivity peaks in the region of the far- and mid-infrared frequencies for periodicities ∼100 nm. The width and position of the peaks can be changed by dialling the parameters of the deformation profiles. The enhancement of the optical conductivity is due to intraband transitions and the translational invariance breaking in the geometrically deformed background. Furthermore, we derive an analytical solution of the Dirac equation in a curved space for a general deformation along one spatial direction. For this class of geometries, it is shown that curvature induces an extra phase in the electron wave function, which can also be explored to produce interference devices of the Aharonov–Bohm type.