Miracle-dz/UniFAR-FTUs huggingface dataset:
Approximate Analysis of Resonant LLC DC-DC Converter

This paper presents an approximate analysis of LLC resonant converter with capacitive filter operating above and below resonance. An equivalent ac resistance model of the rectifier valid for discontinuous as well as continuous conduction modes is proposed. The dc voltage conversion ratio is then obtained using the fundamental harmonic approximation analysis method. Based on the analysis, LLC converter design plots and guidelines are suggested. The theory is verified by simulation and experiment.
Draft Genome Sequences of Three Nontypeable Strains of Haemophilus influenzae, C188, R535, and 1200, Isolated from Different Types of Disease

ABSTRACT Nontypeable Haemophilus influenzae is a persistent human respiratory pathogen known to be involved in a range of acute and chronic respiratory diseases. Here, we report the genome sequences of three H. influenzae strains isolated from sputum, otitis media, and blood. Comparative analyses revealed significant differences in the gene contents including the presence of genes mediating antibiotic resistance.
Robust stability of nonlinear model-based networked control systems with constant update times

Based on the model-based control we make some analysis about nonlinear systems, which is connected with a linear model plant in their actuator side. Nonlinear systems of interest are those, which are composed by linear part plus nonlinear perturbation. Then the bound of its perturbation is estimated to ensure the stability and ultimately bounded of the whole networked control systems. The constant update times is discussed.
FOREARM VENOUS RESPONSES TO STIMULATION OF ADRENERGIC RECEPTORS.

The properties of the adrenergic receptors in the veins or capacitance vessels of man have not been defined completely. Norepinephrine causes constriction of resistance vessels by stimulation of alpha receptors (2); it also causes constriction of the veins or capacitance vessels (3-5). Isoproterenol causes dilatation of resistance vessels by stimulation of beta receptors (6), but reports of its action on the capacitance vessels are conflicting. It appears to cause forearm venous constriction when administered systemically (7), but dilatation is said to occur with infusion into the brachial artery (8). The experiments to be reported here were done to investigate the effects of stimulation of alpha and beta receptors in the veins of the forearm of man in a systematic fashion.
Rotational grid, PAI‐maximizing crime forecasts

Crime forecasts are sensitive to the spatial discretizations on which they are defined. Furthermore, while the Predictive Accuracy Index (PAI) is a common evaluation metric for crime forecasts, most crime forecasting methods are optimized using maximum likelihood or other smooth optimization techniques. Here we present a novel methodology that jointly (1) selects an optimal grid size and orientation and (2) learns a scoring function with the aim of directly maximizing PAI. Our method was one of the top performing submissions in the 2017 NIJ Crime Forecasting challenge, winning 9 of the 20 PAI categories under the name of team PASDA. We illustrate the model on data provided through the competition from the Portland Police Department.
Iterative refinement of fibroglandular region with microwave breast imaging

A procedure is proposed in the context of microwave breast imaging to iteratively refine the resolution of the reconstruction model for the glandular region used by the imaging algorithm. The reconstruction model begins with a small number of large reconstruction elements and the dielectric properties are estimated over these elements. For subsequent iterations, the density of the mesh elements within the glandular region increases. The imaging algorithm uses the results from the reconstructed image of the previous step to initialize the dielectric properties of the model elements. An incident field with a higher frequency than the previous step is used. Dielectric properties over the finer model elements are estimated from the scattered data which have a higher spectral content. The procedure continues until a satisfactory resolution of the reconstructed image is achieved. The aim of the strategy is to improve the resolution of the reconstructed profile while overcoming problems associated with solving a highly non-linear and severely ill-posed inverse scattering problem. The feasibility of the algorithm is evaluated with numerical results based on a synthetically generated breast phantom.
Persistent cognitive deficits in community-treated alcoholic men and women volunteering for research: limited contribution from psychiatric comorbidity.

OBJECTIVE The contribution of psychiatric comorbidity to cognitive status was assessed in a sample of treatment-seeking alcoholics who met criteria to participate in studies of effects of chronic alcohol misuse on brain structure and cognition. METHOD Alcoholic men (n = 43) and women (n = 21) who responded to notices about a research study were screened, clinically assessed and administered Wechsler Memory and Intelligence tests after 3 months of sobriety, on average. Cognitive performance was compared with that of an age-matched sample of healthy controls (n = 51). RESULTS As a group, the alcoholics achieved significantly lower scores than controls on summary indices of the Wechsler Memory and Adult Intelligence Scales and showed greater decline from estimated premorbid intelligence levels than controls. Almost 60% of the alcoholics had at least one additional psychiatric (mood or anxiety) or past substance-dependence comorbidity. There were no marked sex differences in patterns of comorbidity. Comorbid alcoholics were younger, had consumed less alcohol over their lifetime and performed between noncomorbid alcoholics and controls on all tests. CONCLUSIONS Mood and anxiety comorbidity did not necessarily compound poor cognitive test performance associated with chronic alcohol misuse. While unexpected, this finding suggests that, in this sample, poorer cognitive performance was more a function of alcoholism per se than nonalcoholic comorbidity.
Novel and Expanded Roles for MAPK Signaling in Arabidopsis Stomatal Cell Fate Revealed by Cell Type–Specific Manipulations[C][W]

Mitogen-activated protein kinase (MAPK) signaling networks regulate numerous eukaryotic biological processes. In Arabidopsis thaliana, signaling networks that contain MAPK kinases MKK4/5 and MAPKs MPK3/6 function in abiotic and biotic stress responses and regulate embryonic and stomatal development. However, how single MAPK modules direct specific output signals without cross-activating additional downstream processes is largely unknown. Studying relationships between MAPK components and downstream signaling outcomes is difficult because broad experimental manipulation of these networks is often lethal or associated with multiple phenotypes. Stomatal development in Arabidopsis follows a series of discrete, stereotyped divisions and cell state transitions. By expressing a panel of constitutively active MAPK kinase (MAPKK) variants in discrete stomatal lineage cell types, we identified a new inhibitory function of MKK4 and MKK5 in meristemoid self-renewal divisions. Furthermore, we established roles for MKK7 and MKK9 as both negative and (unexpectedly) positive regulators during the major stages of stomatal development. This has expanded the number of known MAPKKs that regulate stomatal development and allowed us to build plausible and testable subnetworks of signals. This in vivo cell type–specific assay can be adapted to study other protein families and thus may reveal insights into other complex signal transduction pathways in plants.
FATTY ACIDS AND ANTIOXIDANT ACTIVITY IN VEGETABLE OILS USED IN COSMETIC FORMULATIONS

The objective of the work was to study the chemical content of a few vegetable oils and its correlation with their antioxidant activity following the use of oils in cosmetic and therapeutic purposes. A number of vegetable oils ( rose hip, flax, hemp, thistle, safflower, camelina) were analyzed by gas chromatography coupled with mass spectrometry (GC-MS), establishing the profile of unsaturated and polyunsaturated fatty acids. Antioxidant activities were determined by FRAP method (Ferric Ability Reducing of Plasma) and it has been attempted correlation with the composition ratio of linoleic acid (omega-6) and linolenic acid (omega-3). It was found that only the hemp oil exhibits the optimal value of this omega acids ratio.
Development and Chemical Stability Studies of Alcohol-Free Phenobarbital Solution for Use in Pediatrics: a Technical Note

Phenobarbital an anticonvulsant drug and tranquilizer, is frequently used in pediatric medicine usually as an oral solution. Due to the poor aqueous solubility, ethanol has been used as a cosolvent for increasing the solubility of Phenobarbital. Nowadays, there is a tendency to eliminate ethanol from oral preparations in general, particularly in pediatric medicine. Therefore, the aim of the present study was to investigate the solubility of Phenobarbital in various oral cosolvents and to present ethanol-free oral solution of Phenobarbital for pediatrics. The chemical stability of the solutions was also investigated. In this research, mixtures of water, propylene glycol and glycerin were prepared with different ratios to obtain optimum solubility where crystallization and crystal growth did not occur at 4 ? C for a period of 2 months and the pH of the solutions was adjusted at 4.5. The results showed that only formulations containing 10-12% propylene glycol, 26-28% glycerin and 0-20% water had no crystal growth. Chemical stability (shelf-life) of the selected formulations was investigated using Arrhenius accelerated stability test. The chemical stability results showed that these formulations were stable over the period of 2 years.
Susceptibility of the cerebellum to thiamine deficiency

Thiamine or vitamin B1, an essential nutrient absorbed from the diet, is involved in vital brain metabolic and cellular functions, including carbohydrate metabolism and neurotransmitter production. Diencephalic regions and, in particular, the cerebellum demonstrate lesions in cases of prolonged thiamine deficiency, such as that observed in alcohol-dependent individuals or in patients with cancer or AIDS. The purpose of this review is to demonstrate recent evidence of cerebellar dysfunction resulting from thiamine deficiency and to assemble theories as to why the cerebellum may be sensitive to this type of insult. A brief outline on cerebellar structure and function, as well as a short discussion on thiamine and thiamine deficiency are provided before detailing the conditions and mechanisms underlying thiamine deficiency-induced cerebellar dysfunction. Although much is known regarding cell loss from a lack of thiamine, further work is still required to identify the sequelae of events leading to the susceptibility of the cerebellum to injury stemming from a thiamine deficient diet or impaired thiamine utilization.
An Approach to Checking Behavioral Compatibility between Web Services

This paper proposes an approach to checking behavioral compatibility between Web services. If Web service B can be used in replacement of Web service A in such a way that the replacement is transparent to clients, Web service B is compatible to Web service A. We use state machines with guarded transitions to specify behaviors of Web services. To check compatibility between two Web services, we propose an extended version of the conventional methods rule, which has been used in object-oriented paradigm. To support our approach, we have implemented a tool. First, the tool constructs a state machine for a Web service whose behavior is expressed in WSDL and WSCI. Then, the tool can verify compatibility between Web services by using the extended methods rule.
An evaluation of shared reading groups for adults living with dementia: preliminary findings

Purpose – Although there is a growing evidence base for the value of psychosocial and arts-based strategies for enhancing well-being amongst adults living with dementia, relatively little attention has been paid to literature-based interventions. The purpose of this paper is to assess the impact of shared reading (SR) groups, a programme developed and implemented by The Reader Organisation, on quality of life for care home residents with mild/moderate dementia. Design/methodology/approach – In total, 31 individuals were recruited from four care homes, which were randomly assigned to either reading-waiting groups (three months reading, followed by three months no reading) or waiting-reading groups (three months no reading, followed by three months reading). Quality of life was assessed by the DEMQOL-Proxy and psychopathological symptoms were assessed by the Neuropsychiatric Inventory Questionnaire. Findings – Compared to the waiting condition, the positive effects of SR on quality of life were demonstrated at the commencement of the reading groups and were maintained once the activity ended. Low levels of baseline symptoms prevented analyses on whether the intervention impacted on the clinical signs of dementia. Research limitations/implications – Limitations included the small sample and lack of control for confounding variables. Originality/value – The therapeutic potential of reading groups is discussed as a positive and practical intervention for older adults living with dementia.
Automatically Generated Keywords: A Comparison to Author-Generated Keywords in the Sciences

This paper examines the differences between author-generated keywords and automatically generated keywords in one area of scientific and technical literature. Using inverse frequency, keywords produced using both methods are examined using a maximum likelihood algorithm. By reducing the scope and size of the corpus of literature examined, this study more closely emulates the information gathering processes of scientists and technologists. Care was taken in developing the sample used, balancing statistical factors to allow interpretable outcomes and replication. The results of the study indicated there are no statistically significant differences between the two techniques.
Level of aspiration in stutterers and nonstutterers.

THAT many kinds of neurotic or maladaptive behavior have defensive or protective functions is by now quite well established. When the symptom strikes such a crucial area for social living as that of speech, in the case of stuttering or stammering, it may serve a number of such functions. Many of these have been described in the past by such writers as Fletcher (2), Fenichel (1), Travis (11, 12), Solomon (10), and Glauber (3). Recently Sheehan analyzed some of the defensive functions of the disorder in developing a theory of stuttering as approach-avoidance conflict (7, 8). As part of its protective function, the disorder automatically keeps its possessor out of many kinds of dangerous competition. Through the stuttering, certain aspirations must be abandoned which would involve threat of failure, or threat of success. The boy who feels impelled to follow his father's footsteps in becoming an eloquent lawyer, radio announcer, or community leader is spared the conflicts of successful or unsuccessful striving in these areas. So important is the goal-setting and aspiration behavior of stutterers that therapy usually involves, at some point, dealing with the adaptiveness of the stutterer's goals, and the relation of these to the disorder. Among the mysteries of stuttering is the sex ratio in its occurrence; it is three or four times more common in males. In investigating goalsetting behavior and possible defensiveness of stutterers it is important to explore sex differences at the same time. A previous report (9) by the authors, employing twenty stutterers and twenty controls, left the level of aspiration of stutterers in a statistical "zone of uncertainty," so that the hypothesis of no difference could be neither accepted nor rejected with assurance. In the present study the experimental group has been doubled and the control group tripled, with more precise matching and a better approxima-
Concept for body coupling in SOI MOS transistors to improve multi-finger triggering

Multi-finger SOI MOS devices exhibit a low ESD failure current, related to the thin Si-film and the complete isolation of the transistor body regions, causing non-uniform conduction in bipolar snapback mode. The traditional layout approaches (silicide blocked junctions, increased gate length) are compared and a novel layout concept is proposed to improve uniform triggering. Excellent ESD performance around 3mA/um2 is achieved for minimum dimension, fully silicided devices in a 90 nm SOI technology.
Post‐transcriptional regulator (rex) of HTLV‐1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins.

Gene expression of human T‐cell leukemia virus type 1 (HTLV‐1) is regulated by two trans‐acting factors encoded by the pX region, p40tax and p27tax.p40tax is a transcriptional activator and p27rex is a post‐transcriptional regulator. Using full‐length viral DNA, we studied the regulatory effects of rex on HTLV‐1 gene expression. p27rex is required for expression of both gag and env proteins, increasing the level of their mRNAs. The effect was dependent on the dose of p27rex expression plasmid. In parallel, increased doses of p27rex suppressed the expression of fully spliced pX mRNA, which encodes the regulatory proteins. These two effects of p27rex operated at the post‐transcriptional level and were independent of transcriptional regulation. Lowering the level of pX mRNA down‐regulates transcription of the proviral genome. These observations demonstrate that rex is a positive post‐transcriptional regulator for gag, pol and env protein expression, and acts at the same time as an indirect negative regulator of viral transcription.
Histopathological Features of Gastrointestinal Stromal Tumors and the Contribution of DOG1 Expression to the Diagnosis.

BACKGROUND Gastrointestinal stromal tumors (GIST) have KIT or platelet-derived growth factor receptor α (PDGFRα) mutations affecting receptor tyrosine kinase activity and do not benefit from classic treatment regimens. AIMS The aim of this study was to review the algorithm that may be followed for the diagnosis and differential diagnosis in GISTs by investigating the histomorphological parameters and expression characteristics of classical immunohistochemical antibodies used in routine tests in addition to DOG1 expression. STUDY DESIGN Diagnostic accuracy study. METHODS We reevaluated the histological and immunohistochemical parameters of 37 GISTs. The standard immunohistochemical diagnosis and differential diagnosis panel antibodies (CD117, PDGFRα, CD34, vimentin, desmin, SMA, S-100, and Ki67) were studied on the tumor sections. We also used the popular marker DOG1 antibody with accepted sensitivity for GISTs in recent years and the PDGFRα immune marker for which the benefit in routine practice is discussed. RESULTS Classification according to progressive disease risk groups of the 37 cases revealed that 54% were in the high risk, 19% in the moderate risk, 16% in the low risk, 8% in the very low risk and 8% in the no risk group. Cytological atypia, necrosis, mucosal invasion and the Ki67 index were found to be related to the progressive disease risk groups of the tumors (p<0.05). Positive immunoreaction was observed with CD117 and PDGFRα in all GISTs in the study (100%). Positivity with the DOG1 antibody was found in 33 (89%) cases. CD34 was positive in 62% (23) of the cases. CONCLUSION The CD117 antibody still plays a key role in GIST diagnosis. However, the use of DOG1 and PDGFRα antibodies combined with CD117 as sensitive markers can be beneficial.
Clathrin-Independent Trafficking of AMPA Receptors

Membrane trafficking of AMPA receptors (AMPARs) is critical for neuronal function and plasticity. Although rapid forms of AMPAR internalization during long-term depression (LTD) require clathrin and dynamin, the mechanisms governing constitutive AMPAR turnover and internalization of AMPARs during slow homeostatic forms of synaptic plasticity remain unexplored. Here, we show that, in contrast to LTD, constitutive AMPAR internalization and homeostatic AMPAR downscaling in rat neurons do not require dynamin or clathrin function. Instead, constitutive AMPAR trafficking is blocked by a Rac1 inhibitor and is regulated by a dynamic nonstructural pool of F-actin. Our findings reveal a novel role for neuronal clathrin-independent endocytosis controlled by actin dynamics and suggest that the interplay between different modes of receptor endocytosis provides for segregation between distinct modes of neuronal plasticity.
Avaliação dos efeitos antitumorais da própolis vermelha em células humanas in vitro

A propolis vermelha brasileira tem atraido interesses cientificos e economicos devido as suas variadas atividades biologicas. Este produto natural possui composicao quimica variada de acordo com a regiao na qual e encontrado, sendo necessaria uma completa caracterizacao quimica para cada tipo de propolis, a fim de se elucidar os compostos presentes e responsaveis pela atividade biologica observada. Neste trabalho, buscou-se caracterizar quimicamente os extratos da propolis vermelha brasileira, avaliar sua atividade antitumoral, bem como alguns mecanismos de morte celular, alem de investigar o padrao proteico de celulas tumorais de laringe (Hep-2) e nao tumorais de rim (Hek-293) tratadas e nao tratadas com extratos da propolis vermelha atraves da analise proteomica comparativa. A caracterizacao quimica mostrou que a propolis apresenta moleculas complexas, principalmente isoflavonoides, que possuem importantes atividades biologicas, dentre elas a atividade antitumoral. A atividade citotoxica de duas fracoes e do extrato hidroalcoolico da propolis foi avaliada na linhagem tumoral Hep-2, a qual se revelou mais citotoxica nos tratamentos com as fracoes investigadas. Os ensaios de citometria mostraram que as celulas que receberam tratamento apresentaram menor potencial de membrana mitocondrial, maior quantidade de celulas em apoptose tardia (TUNEL e Anexina-V/PI), menor geracao de especies reativas do oxigenio e o aumento de fragmentacao do DNA. Alem disto, as coloracoes revelaram a presenca de corpos apoptoticos e condensacao de cromatina. A analise proteomica permitiu a comparacao dos mapas proteicos da linhagem Hep-2, na ausencia ou presenca de extratos da propolis vermelha, com a linhagem nao tumoral Hek-293. Estas proteinas foram classificadas de acordo com os processos biologicos as quais estao envolvidas. Alem disto, doze proteinas identificadas na linhagem Hep-2 apresentaram expressao reduzida comparada ao grupo controle, dentre as quais muitas estao presentes em grande quantidade em outros tumores e sao consideradas biomarcadores tumorais. Os resultados, de forma geral, mostram que a propolis interfere em um conjunto de eventos intracelulares e, assim, passa a ser uma candidata promissora para inibir o crescimento celular e contribuir para os diferentes passos relacionados com o processo de carcinogenese. Embora os mecanismos moleculares pelos quais a propolis vermelha interaja com o metabolismo das celulas permanecam ainda desconhecidos, estudos adicionais servirao para melhor elucidar a atividade antitumoral da propolis vermelha brasileira e de suas fracoes.