Miracle-dz/UniFAR-FTUs huggingface dataset:
A decentralized H∞ control scheme for robust routing in networks

A new decentralized routing strategy using H infin optimal control is introduced in this paper. For each node a local state feedback control is designed such that the proposed global objective function which is the worst-case queuing length is minimized. By taking advantage of H infin control theory, a robust routing performance in the presence of unknown fast time varying network delays is achieved. The resulting optimization problem is then recast as a linear objective minimization problem involving linear matrix inequality (LMI) constraints. The physical constraints are also expressed as LMI feasibility conditions. Simulation results are presented to illustrate and demonstrate the effectiveness of our proposed routing strategy.
Translation and validation into Portuguese language of the medication regimen complexity index.

BACKGROUND The complexity of pharmacotherapy is a result of a multiplicity of prescribed regimen factors, including the number of different drugs in the regimen, the number of dosage units per dose, the total number of prescribed doses per day and administration instructions. The Medication Regimen Complexity Index (MRCI) is a specific, reliable and valid tool used to measure the complexity of pharmacotherapy, originally developed in English language. OBJECTIVE Transcultural translation and validation of this tool into Brazilian Portuguese. METHODS A cross-sectional study was developed with 95 type-2 diabetes patients, receiving multiple medications. The validation process included translation into Portuguese, back-translation and pre-test of the tool, creating a new version called the Pharmacotherapy Complexity Index (PCI). The psychometric parameters were assessed, including convergent validity, discriminant validity and reliability (interclass and test-retest correlation). RESULTS The complexity of pharmacotherapy measured by the MRCI-Brazil had an average score of 15.7 points (SD=8.36). MRCI-Brazil showed significant correlation with the number of medications (r=0.86; p<0.001) and age of patients (r=0.28, p=0.005). Interrater reliability analysis found an intra-class correlation (ICC) of 0.99 (p<0.001) and test-retest correlation was of 0.997 (p<0.001). CONCLUSION The results have shown that the Brazilian version of the MRCI presents adequate validity and reliability, and may be useful in clinical practice and research involving the analysis of the drug regimen complexity.
PTSD in different treatment settings: A preliminary investigation of PTSD symptomatology in substance abuse and chronic pain patients

Received for publication 1 June 1999; Accepted 10 December 1999 INTRODUCTION Recent research has shown that more than a quarter of patients seeking treatment for chronic pain [Asmundson et al., 1998; Blanchard et al., 1994; Hichling et al., 1992; Hickling and Blanchard, 1992; Jasper, 1998] and substance abuse [Bonin et al., 1999; Dansky et al., 1997; Deykin and Buka, 1997; Najavits et al., 1997] have post-traumatic stress disorder (PTSD). Since chronic pain and substance abuse are common in our society, these groups provide researchers with an opportunity to compare PTSD symptom presentations in two quite different groups. The few studies that have addressed differences in PTSD symptoms have shown that the symptoms differ according to type of trauma experienced and the population studied [e.g., Deering et al., 1996]. For example, past research has shown that participants with chronic pain and PTSD heavily endorse reexperiencing symptoms [Beckman et al., 1997], while participants diagnosed with alcohol abuse and PTSD report higher arousal and avoidance symptoms [Saladin et al., 1995]. With the high prevalence rates of PTSD found in substance abuse treatment programs [e.g., Brown et al., 1995; Deykin and Buke, 1997], further research is needed to examine how patients identified with PTSD with different types of comorbidity differ in their presentation of PTSD symptoms. If major differences do exist, this may suggest that different approaches to treatment may increase efficacy and efficiency of the therapy process. Thus, we performed a preliminary investigation to determine whether patients with comorbid PTSD and substance abuse and comorbid PTSD and chronic pain differ on a self-report measure that assessed severity and frequency scores on PTSD symptoms.
Embedded model-based fault diagnosis for on-board diagnosis of engine control systems

In this paper, a model-based fault diagnosis scheme for on-board diagnosis in spark ignition (SI) engine control systems is presented. The developed fault diagnosis system fully makes use of the available control structure and is embedded into the control loops. As a result, the implementation of the diagnosis system is realized with low demands on engineering costs, computational power and memory. The developed diagnosis scheme has been successfully applied to the air intake system of an SI-engine
Helicobacter pylori DNA in Drinking Water in Japan

Helicobacter pylori has been detected in drinking water in Peru and Sweden, suggesting the possibility of water‐borne transmission. To date there have been few reports of H. pylori being detected in water; one was of the ureA gene of H. pylori in wells and springs in rural Japan. We examined water sampled in or near urban areas of Japan for H. pylori DNA by three assays using the polymerase chain reaction (PCR). Near Tokyo, samples were obtained: 10 of tap water, 6 of well water, 10 of river water, and 10 of sea water. Samples were filtered with membranes with 0.05‐ or 0.22‐μm pores, which bacterial cells are caught by. Bacterial nucleic acids were extracted and purified and the PCR was done to amplify adhesin specific for H. pylori and the ureA gene, if present. Real‐time PCR that measured the yield in terms of fluorescence was done with primers for 16S rRNA. None of the samples of tap, river, or sea water contained adhesin, ureA or 16S rRNA. None of the 6 samples of well water contained adhesin or ureA, but 2 of the 6 samples contained 16S rRNA. Some of the users of the well had had H. pylori infection in the past H. pylori DNA was detected in well water and the users had been infected, so water‐borne transmission via well water may occur even in towns in Japan.
Minimum Inhibitory Concentration (MIC) versus Minimum Biofilm Eliminating Concentration (MBEC) in Evaluation of Antibiotic Sensitivity of Gram-negative Bacilli Causing Peritonitis

Objective Minimum inhibitory concentration (MIC) and minimum biofilm eliminating concentration (MBEC) results were compared to determine changes in the pattern of antibiotic sensitivity of gram-negative bacilli from the planktonic to the biofilm phase of growth. Methodology The MIC and MBEC assays were conducted on stored isolates obtained from patients presenting with peritoneal dialysis-related gram-negative peritonitis with Escherichia coli or Pseudomonas. Results The antibiotic sensitivities of planktonic organisms tested by the MIC assays were significantly higher than the antibiotic sensitivities of the same organisms in their biofilm state, as tested by the MBEC assays. Conclusions In their biofilm state, gram-negative bacteria are much less susceptible to antibiotics compared to their antibiotic susceptibility in the planktonic state.
ZAP-70 in B cell malignancies

ZAP-70 has emerged as a protein of potential prognostic importance in chronic lymphocytic leukemia (CLL) following gene expression profiling which compared the 2 well established prognostic sub-sets, those with unmutated and mutated IgVH genes. This protein tyrosine kinase (PTK), known to be of importance in T and NK cell signaling but absent in normal peripheral B cells, is expressed in the majority of the poorer prognosis unmutated CLL and absent in most cases with mutated IgVH genes. ZAP-70 has been shown to be functionally important in the CLL cases in which it is expressed; it is also important in B cell development in mice and there is preliminary evidence for its expression in human B cell progenitors and activated B cells. Whether its expression in a sub-set of CLL cases is a result of a more activated cell type or a reflection of the stage of maturation of the transforming event(s) in CLL is open to debate. ZAP-70 is expressed in a minority of other B cell tumors but correlation with IgVH gene mutational status is lacking. The problems with ZAP-70 measurement, which has yet to be standardized, are reviewed together with its current status as a prognostic marker in CLL.
Buoyancy of Atlantic cod larvae in relation to developmental stage and maternal influences

In this experimental study on Atlantic cod, Gadus morhua, buoyancy was found to vary significantly with season, developmental stage, egg size and maternal condition. Before the start of the experiments, wild fish were caught in the Barents Sea and acclimatized to laboratory conditions. Pairs (n = 8), one female (recruit spawner) and one male, spawned naturally in large, indoor compartments of a circular tank and every third egg batch (out of up to 19 batches collected per female) was incubated in aquaria. Following sedation (50 mg l -1 metomidate hydrochloride, 30 min), individual larval specific gravity was precisely reported (30 min) using a density-graduated column. Larval specific gravity (mean σ t ) increased steadily during the first early stages of development (0-25 day-degrees), remained nearly constant during the following stages (25-35 day-degrees), but then decreased gradually (35-55 day-degrees). In general, late-season larvae were significantly less buoyant, i.e. showed higher mean σ than early-season larvae. Mean σ t was negatively correlated with female condition and egg size and dry weight. Possible implications of these findings for drift and survival are discussed.
INTEGRACIÓN AGROECOLÓGICA Y SOBERANÍA ENERGÉTICA

La estrategia cubana de sustitucion de quimicos por biologicos en los ultimos 25 anos, ha gene- rado conocimiento sobre sistemas agricolas sustentables con agricultores innovadores e investi- gadores. Las lineas para integrar el manejo de agroecosistemas son: diversificacion genetica y tec- nologica, integracion ganaderia/agricultura y autosuficiencia alimentaria de animales y humanos, combinadas en sistemas diversificados, integrados y autosuficientes, de adaptacion local, resilientes y sostenibles. Un sistema sostenible debe alcanzar autosuficiencia al menor costo posible, eficiencia energetica, minimo impacto ambiental y maxima satisfaccion de las necesidades humanas. Se pre- sentan resultados de productividad y eficiencia energetica de dos sistemas integrados (pequena y mediana escala) con alta productividad y eficiencia a partir de un sistema diversificado integrado con base agroecologica. Muchas investigaciones fueron realizadas en Cuba durante los noventa e inicios del presente siglo, sobre sistemas de alimentacion no convencional de especies animales y sistemas integrados suelo-pasto-animal. Un reciente estudio internacional formulo preguntas para definir politicas agricolas globales de investigacion y practica agricola, similares a los sistemas in- tegrados para la produccion de alimentos y energia, realizados en el proyecto Biomas-Cuba sobre sistemas integrados sustentables alimentos/energia para la produccion agropecuaria, que carac- terizan distintos tipos de fincas en funcion de su conversion (fuerte integracion alimentos/energia, en vias de integracion y estadios iniciales). Si estos sistemas integrados fueran adoptados gradual- mente sobre tres millones de hectareas–mitad de la tierra cultivada en Cuba–, se podrian satisfacer todas las necesidades alimentarias de la poblacion en un periodo de tres anos.
Historical effects on beta diversity and community assembly in Amazonian trees

We present a unique perspective on the role of historical processes in community assembly by synthesizing analyses of species turnover among communities with environmental data and independent, population genetic-derived estimates of among-community dispersal. We sampled floodplain and terra firme communities of the diverse tree genus Inga (Fabaceae) across a 250-km transect in Amazonian Peru and found patterns of distance-decay in compositional similarity in both habitat types. However, conventional analyses of distance-decay masked a zone of increased species turnover present in the middle of the transect. We estimated past seed dispersal among the same communities by examining geographic plastid DNA variation for eight widespread Inga species and uncovered a population genetic break in the majority of species that is geographically coincident with the zone of increased species turnover. Analyses of these and 12 additional Inga species shared between two communities located on opposite sides of the zone showed that the populations experienced divergence 42,000–612,000 y ago. Our results suggest that the observed distance decay is the result not of environmental gradients or dispersal limitation coupled with ecological drift—as conventionally interpreted under neutral ecological theory—but rather of secondary contact between historically separated communities. Thus, even at this small spatial scale, historical processes seem to significantly impact species’ distributions and community assembly. Other documented zones of increased species turnover found in the western Amazon basin or elsewhere may be related to similar historical processes.
Laugier‐Hunziker syndrome: treatment with cryosurgery

Rhodes AR. Neoplasms: benign neoplasias, hyperplasias and dysplasias of melanocytes. In: Fitzpatrick TB, editor. Dermatology in General Medicine (ch. 81), New York McGraWHill, 1993. p. 1045. Calista D, Schianchi S, Landi C. Malignant blue nevus of the scalp. Int J Dermatol 1998;37:126-127. Goldenhersh MA, Savin RC, Bamhill RL, Stenn KS. Malignant blue nevus. Case report and literature review. J Am Acad Dermatol 1988; 19: 7 12-722. Bennaceur S, Fraitag S, Teillac-Hamel D, Bodemer C, Berdah S, Chretien-Marquet B. Naevus bleu gtant congtnital de l’extrBmitt cervico-ctphalique. Ann Dermatol Venereol 1996; 1235307-8 10.
A New Quasi-3-D Compact Threshold Voltage Model for Pi-Gate (ΠG) MOSFETs With the Interface Trapped Charges

With the effects of equivalent oxide charges on the flat-band voltage, a new quasi-three-dimensional (quasi-3-D) compact threshold voltage model is presented for the pi-gate (ΠG) MOSFETs with the interface trapped charges based on the quasi-3-D scaling equation that accounts for equivalent number of gates and virtual back gate effects induced by the normalized gate extension depth in the buried oxide. The model reveals that a thin gate oxide can effectively reduce the threshold voltage degradation caused by the trapped charges. Opposite to the thin gate oxide, a thick silicon is required to alleviate the threshold voltage shift resulted from the negative trapped charges. For the short-channel behavior, the device with negative/positive trapped charges can decrease/increase the threshold voltage roll-off caused by the short-channel effects. Due to its computational efficiency and simple formula, the model can be easily used to explore the threshold behavior for the charges trapping ΠG MOSFETs.
Survivable Virtual SDN Embedding Approach for Innovative Cloud Data Network

Software-defined networking (SDN) has separated control and forwarding planes, which is a powerful approach to enable network virtualization by SDN hypervisors to share physical SDN networks among multiple virtual SDN in cloud data center. However, the centralized control and virtual network shared physical network are delicately weak and easy to failure if virtual topology embedding is not properly designed. This paper develops an enhanced virtual controller node mapping strategy to improve the survivability of virtual SDN. The strategy explicitly considers the network delay and the number of disjoint path between controller and forwarding devices to form survivable factor. Our proposed approach has been evaluated and the results show that the proposed technology has improved the survivability and network delay of virtual SDN while keeping the other within reasonable bounds.
Possible use of a H3R antagonist for the management of nonmotor symptoms in the Q175 mouse model of Huntington's disease

Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder characterized by motor as well as nonmotor symptoms for which there is currently no cure. The Q175 mouse model of HD recapitulates many of the symptoms identified in HD patients including disruptions of the sleep/wake cycle. In this study, we sought to determine if the daily administration of the histamine‐3 receptor (H3R) antagonist/inverse agonist 6‐[(3‐cyclobutyl‐2,3,4,5‐tetrahydro‐1H‐3‐benzazepin‐7‐yl)oxy]‐N‐methyl‐3‐pyridinecarboxamide hydrochloride (GSK189254) would improve nonmotor symptoms in the Q175 line. This class of drugs acts on autoreceptors found at histaminergic synapses and results in increased levels of histamine (HA). HA is a neuromodulator whose levels vary with a daily rhythm with peak release during the active cycle and relatively lower levels during sleep. H3Rs are widely expressed in brain regions involved in cognitive processes and activation of these receptors promotes wakefulness. We administered GSK189254 nightly to homozygote and heterozygote Q175 mice for 4 weeks and confirmed that the plasma levels of the drug were elevated to a therapeutic range. We demonstrate that daily treatment with GSK189254 improved several behavioral measures in the Q175 mice including strengthening activity rhythms, cognitive performance and mood as measured by the tail suspension test. The treatment also reduced inappropriate activity during the normal sleep time. The drug treatment did not alter motor performance and coordination as measured by the challenging beam test. Our findings suggest that drugs targeting the H3R system may show benefits as cognitive enhancers in the management of HD.
MicroRNA-26 b inhibits osteosarcoma cell migration and invasion by down-regulating PFKFB 3 expression

MicroRNAs regulate target gene expression and are involved in cell proliferation, apoptosis, differentiation, tumor invasion, and cancer stem cell regulation, among other processes. MicroRNA-26b (miR-26b) is closely related to tumor occurrence and development. In this study, we analyzed miR-26b expression in osteosarcoma tissue, its effect on Saos-2 osteosarcoma cell proliferation and invasion, and its relationship with 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) expression. Osteosarcoma tissue was obtained from surgical patients and normal tissue adjacent to the tumor was used as a control. Real-time polymerase chain reaction was applied to detect miR-26b expression in cancer tissue and normal tissue. A vector expressing miR-26b was constructed and transfected into Saos-2. An MTT assay, cell invasion assay, and scratch experiment were used to analyze the effect of miR26b on Saos-2 cell proliferation, invasion, and migration abilities. Western blotting analysis was performed to investigate the role of miR-26b on PFKFB3 expression. miR-26b expression in normal tissue was 7.55-fold higher than in osteosarcoma tissue (t = 10.20, P = 0.006). Compared with ©FUNPEC-RP www.funpecrp. com.br Genetics and Molecular Research 14 (4): 16872-16879 (2015) 16873 miR-26b in osteosarcoma ©FUNPEC-RP www.funpecrp. com.br Genetics and Molecular Research 14 (4): 16872-16879 (2015) control tissue, miR-26b significantly inhibited osteosarcoma proliferation, migration, and invasion (P < 0.05). Western blotting results revealed that PFKFB3 protein expression decreased in Saos-2 cells after transfection with miR-26b. miR-26b was down-regulated in osteosarcoma tissue. miR26b may inhibit osteosarcoma cell proliferation, migration, and invasion by regulating PFKFB3 protein expression. miR-26b may have a tumor suppressor role in tumor occurrence and development.
Putative alpha-helical structures in the human immunodeficiency virus type 1 Vpu protein and CD4 are involved in binding and degradation of the CD4 molecule

The human immunodeficiency virus type 1 (HIV-1) vpu gene encodes a 16-kDa class I integral membrane phosphoprotein with an N-terminal membrane-spanning region and a C-terminal cytoplasmic domain. In the cytoplasmic domain, two amphipathic alpha-helices joined by a flexible turn containing two phosphoacceptor sites have been predicted. Previous studies have shown that Vpu downregulates CD4 molecules by inducing their specific degradation in the endoplasmic reticulum. Phosphorylation of serine residues 52 and 56, present within the cytoplasmic domain of the Vpu protein, has been shown to be essential to this Vpu function. However, the contribution of these two phosphoacceptor sites in the mechanism of CD4 degradation remains undefined. Interestingly, a specific interaction between Vpu and CD4 was recently demonstrated in coimmunoprecipitation experiments. Binding of Vpu was shown to be necessary but not sufficient to mediate CD4 degradation, indicating that interaction between Vpu and CD4 represents an early step critical in triggering a process leading to CD4 degradation. To delineate the sequence(s) and/or structural determinant(s) involved in this Vpu-CD4 interaction and in the Vpu-mediated CD4 degradation, we performed a mutational analysis of the cytoplasmic domain of CD4 and Vpu. Coimmunoprecipitation experiments reveal that disruption of the putative alpha-helical structure in the membrane-proximal cytoplasmic domain of CD4 affects the binding to Vpu, suggesting that this structure may act as an interface for the CD4-Vpu interaction that mediates CD4 degradation. Vpu proteins containing mutations in either or both of the phosphoacceptor sites (Ser52 or/and Ser56) were inactive in regard to CD4 degradation yet retained the capacity to interact with the cytoplasmic domain of CD4. In an attempt to define the minimal region responsible for this interaction, we tested a panel of mutations which were designed to affect the integrity of the putative alpha-helices present in the cytoplasmic domain of Vpu. Our results indicate that although both C-terminal alpha-helices are required for degradation of CD4, only alpha-helix I, located in the membrane-proximal cytoplasmic region of Vpu, is involved in the interaction between Vpu and CD4. Taken together, these results demonstrate that alpha-helical structures in the HIV-1 Vpu and CD4 proteins are involved in binding and degradation of CD4 molecules.
A 950-MHz rectifier circuit for sensor network tags with 10-m distance

This paper presents a 950-MHz wireless power transmission system and a high-sensitivity rectifier circuit for ubiquitous sensor network tags. The wireless power transmission offers a battery-life-free sensor tag by recharging the output power of a base station into a secondary battery implemented with the tag. For realizing the system, a high-sensitivity rectifier with dynamic gate-drain biasing has been developed in a 0.3-/spl mu/m CMOS process. The measurement results show that the proposed rectifier can recharge a 1.2-V secondary battery over -14-dBm input RF power at a power conversion efficiency of 1.2%. In the proposed wireless system, this sensitivity corresponds to 10-m distance communication at 4-W output power from a base station.