Miracle-dz/UniFAR-FTUs huggingface dataset:
Imaging Atherosclerotic Plaques by Cardiac Computed Tomography In Vitro: Impact of Contrast Type and Acquisition Protocol

Objective:Noninvasive contrast-enhanced coronary computed tomography (CT) angiography enables distinction between calcified and noncalcified atherosclerotic plaques. However, separation of noncalcified plaques into rupture prone lipid-rich and stable fibrous subtypes is challenging because CT density of the plaque, characterized by Hounsfield Units (HU), varies with intraluminal contrast density and acquisition protocol.This study aims at testing the influence of intraluminal contrast densities and kV-settings on coronary plaque density values in vitro. Materials and Methods:We scanned 16 coronary arteries with 3 different contrast solutions (no contrast, 1:70, and 1:23 Iomeron, 350 mgI/mL) and 3 different kV-settings (80, 120, and 140 kV). The arteries were sectioned into 5-mm segments. Every segment was evaluated with CT and histopathology for suitability of analysis, presence, and subtype of plaque. Results:Sixty-four segments were analyzed and classified with CT. Agreement between plaques classified with CT angiography in vitro and histopathology was poor-to-moderate, with no kappa-values above 0.21. The kV-settings affected the CT density in all plaque types. The CT density decreased 0.25 (0.07) HU, P = 0.013 in noncalcified plaques, and 5.5 (0.7) HU, P < 0.0001, in calcified plaques for every kV increase. CT densities in noncalcified plaques changed when the contrast concentration was changed. From no to high contrast concentration resulted in a 21.7 (8.3) HU increase, P = 0.041, and from low to high contrast concentration resulted in a 21.5 (6) HU increase, P = 0.011, causing several plaques to change in subtype from lipid-rich (low contrast concentration) to fibrotic (high contrast concentration). Conclusion:Agreement between CT angiography in vitro and histopathology for classification of coronary plaque subtype is poor to moderate. However, no specific combination seems superior to the most commonly used protocols for distinction between lipid-rich and fibrotic plaque subtypes in current clinical practice.
Novel and faster strategy for effective control of single phase DVR

Due to evolution in the power system, the emergence of smaller generating systems such as micro turbines, Wind Turbines, Solar PV system, etc., have opened new opportunities for onsite power generation which is located at user's site called Distributed Energy Resources (DER). The significant potential of DER to meet customers need and utilities independently can be captured by organizing these resources into Microgrid. With the ever increasing use of Power Electronics devices, Power Quality has become a major concern for utility operators as well as consumers. Power Quality mainly affect due to disturbances like voltage sag, swell, transients (oscillatory and impulsive) momentary interruptions, harmonics, flicker etc. This necessitates monitoring and estimation of these disturbances continuously so that it can be corrected almost instantly. The different methods for power quality indices estimation are RLS, LMS, LES, FFT, Kalman Filter, Wavelet Transform, etc. In this paper very simple and thus faster, Modified Recursive Gauss Newton (MRGN) algorithm for power Quality estimation is used. This estimation is done for the output terminals of the DG and it is further used for a simple control strategy of single phase Dynamic Voltage Restorer (DVR), a series compensating device for power quality improvement in terms of Voltage Sag, Swell and Harmonics during supply disturbances.
Applying HBMO-based SOM in Predicting the Taiwan Steel Price Fluctuation

Steel industry is the fundamental industry of a nation, and it has a closed connection between upstream and downstream. Its development has a great concern with the economic stability and national defense independence of a nation; thus, it represents the nation’s power and is highly emphasized by governments. The related studies on domestic steel industry mostly focus on the current situation of steel industry, for instance, the cooperation in national economic development and the status of supply and demand of steel market. Therefore, via constructing the prediction systems, the findings of the study can show the prediction of the price fluctuation of steel products and provide the steel industry criteria of right purchasing time and quantity, enhancing the effects of the whole performance of Taiwan’s steel industry. This study investigates that, under the two modes of price fluctuation, steel productions have different examinations and different comparisons as the results via two prediction systems: Honey-Bees Mating Optimization Self-Organizing Map (HBMOSOM) and Self-Organizing Map (SOM). The results prove that HBMOSOM prediction system could reach the higher prediction accuracy rate than SOM prediction system. Under the hybrid mode, the prediction accuracy rate of H-beam steel is much higher in HBMOSOM prediction system, while the key factors affecting the price are scrap import prices, Taiwan billet import prices, and the issuance of building construction area the total number of cases. Under the partition mode, the prediction accuracy rate of hot-rolled sheet steel is much higher in HBMOSOM prediction system, while the key factors affecting the price fluctuation of HR stainless coil are the hot-rolled sheet steel price, Taiwan’s hot-rolled sheet steel apparent consumption, raw material prices, and their apparent consumption.
Validation of multifrequency bioelectrical impedance analysis in monitoring fluid balance in healthy elderly subjects.

BACKGROUND Multifrequency Bioelectrical Impedance Analysis (MFBIA) is a novel method to assess body composition in elderly subjects. However, it is unclear whether MFBIA can detect changes in body water compartments in elders. We aimed to determine the within-subject variability of MFBIA and the responsiveness to a diuretic intervention in aged subjects with a stable fluid balance. METHODS We selected 12 healthy active elderly subjects (5 male, 7 female) with a mean age of 75 years. Total body water and extracellular fluid (ECF) were measured by deuterium oxide- and potassium bromide-dilution techniques. Within-subject variability in total body MFBIA was assessed by performing four measurements at 1, 5, 50, and 100 kHz within a 2-month period. Subsequently, responsiveness of MFBIA to the ECF loss caused by oral administration of 40 mg of furosemide was determined. RESULTS Within-subject variability in MFBIA at 1, 5, 50, and 100 kHz expressed as standard deviations was 21, 19, 14, and 14 Ohm (omega), respectively. Furosemide caused a mean weight loss of 1.8 +/- 0.6 kg, which resulted in significant increases in impedance of 57 +/- 24 omega at 1 kHz and 37 +/- 12 omega at 100 kHz (p < .001). The responsiveness of MFBIA for the diuretic intervention was best at 5 kHz (responsiveness index = 1.98). CONCLUSIONS Within-subject variability of MFBIA was small in healthy elderly subjects with stable fluid balance. Responsiveness of MFBIA to 9% furosemide-induced ECF loss was excellent. These data support the necessity for further clinical assessment of the value of MFBIA in monitoring fluid balance in geriatric patients.
Psychosocial Correlates of Survival in Diabetes

The goal of this research was to quantify therelationships between patient survival and a set of explanatory variables in a randomly selected sample of community-based patients with non-insulin-dependent diabetes mellitus (NIDDM). The sample included 343 patients with NIDDM initially entered into the study in 1981–1982 and reexamined in 1985–1986. Mortality data were collected on reexamination in 1985 and updated from death-certificate data through 1 January 1986. The data collected from the patients included demographic and clinical variables, psychosocial variables related to diabetes, measures of physiologic control, hospitalization, and mortality. The Cox proportionalhazards model was used to compute a hazard rate for each individual and to determine risk covariates. The results indicated that the variables most associated with the risk of mortality were patient age, social impact of diabetes, renal function, complexity of diet regimen, and history of smoking. Two of these variables (social impact and complexity of diet regimen) were obtained from the Diabetes Educational Profile completed by all patients on entry to the study. The five predictor variables were more closely related to mortality than diabetes control as measured by HbA1, previous hospital admissions, previous heart attacks, and other physiologic measures frequently used as outcome measures. The only physiologic predictor was renal function.
Shikonin and its derivatives: a patent review

Introduction: Shikonin and its derivatives are the main components of red pigment extracts from Lithospermum erythrorhizon, whose medicinal properties have been confirmed for a long history, and have aroused great interest as the hallmark molecules responsible for their significant biological activities, especially for their striking anticancer effects. Areas covered: Areas covered in this paper include a review of the total synthesis, biological effects and mechanisms of shikonin and its derivatives for their anticancer activities in the past decade, basing on literature and patents. The current state and problems are also discussed. Expert opinion: At present, screening for anticancer shikonin derivatives is based on cellular level to find compounds with stronger cytotoxicity. Though several compounds have been discovered with striking cytotoxicity in vitro, however, no selectivity was observed and undoubtedly, the further outcomes have been disappointing because of their great damage to normal cells. Meanwhile, the presumed mechanisms of action are also established in terms of their cytotoxicity. From a pharmacological point of view, most of the shikonin derivatives are at an early stage of their development, and thus it is difficult to determine the exact effectiveness in cancer treatment. With research in this field going deeper, it can be expected that, despite the difficulties, shikonin derivatives as potential anticancer agents will soon follow.
The combined effects of DEHP and PCBs on phospholipase in the livers of mice

Di(2‐ethylhexyl) phthalate (DEHP) and polychlorinated biphenyls (PCBs) are two widely distributed pollutants that are of great concern due to their adverse health effects. However, few studies have investigated the combined effects of DEHP and PCBs. In this study, adult mice were continuously exposed to mixtures of DEHP (15 mg/kg bodyweight/day) and Aroclor 1254 (7.5 mg/kg bodyweight/day) for 12 days to investigate the combined effects of these compounds. The results showed that the ratio of the liver weight to the body weight was higher in the treated group than that in the control group. The effects of combined exposure on three important receptors, the proliferator‐activated receptor (PPAR), estrogen receptor (ER), and aryl hydrocarbon receptor (AHR), were investigated. The mRNA level of PPARγ was significantly up‐regulated after exposure. The expression level of ERα was decreased in the male treated group. In contrast, the expression levels of AHR and related genes (cyp1a1 and cyp1b1) were not markedly affected. The expression level of phospholipase A (PLA) was significantly down‐regulated at both the mRNA and protein levels in male mice after combined treatment. In all, our study demonstrated the combined effects of DEHP and PCBs on the expression levels of key receptors in mice. The combined exposure led to a decrease in phospholipase in male mice. © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 197–204, 2015.
Dissemination of the Canadian clinical practice guidelines for nutrition support: Results of a cluster randomized controlled trial

Objective:To compare the effectiveness of active to passive dissemination of the Canadian clinical practice guidelines (CPGs) for nutrition support for the mechanically ventilated critically ill adult patient. Design:A cluster-randomized trial with a cross-sectional outcome assessment at baseline and 12 months later. Setting:Intensive care units in Canada. Patients:Consecutive samples of mechanically ventilated patients at each time period. Interventions:In the active group, we provided multifaceted educational interventions including Web-based tools to dietitians. In the passive group, we mailed the CPGs to dietitians. Measurements and Main Results:The primary end point of this study was nutritional adequacy of enteral nutrition; secondary end points measured were compliance with the CPGs, glycemic control, duration of stay in intensive care unit and hospital, and 28-day mortality. Fifty-eight sites were randomized. At baseline and follow-up, 623 and 612 patients were evaluated. Both groups were well matched in site and patient characteristics. Changes in enteral nutrition adequacy between the active and passive arms were similar (8.0% vs. 6.2 %, p = .54). Median time spent in the target glucose range increased 10.1% in the active compared with 1.8% in the passive group (p = .001). In the subgroup of medical patients, enteral nutrition adequacy improved more in the active arm compared with the passive group (by 8.1%, p = .04), whereas no such differences were observed in surgical patients. When groups were combined, during the year of dissemination activities, there was an increase in enteral nutrition adequacy (from 43% to 50%, p < .001), an increase in the use of feeding protocols (from 64% to 76%, p = .03), and a decrease in patients on parenteral nutrition (from 26% to 21%, p = .04). There were no differences in clinical outcomes between groups or across time periods. Conclusions:Although active dissemination of the CPGs did improve glycemic control, it did not change other nutrition practices or patient outcomes except in a subgroup of medical patients. Overall, dissemination of the CPGs improved other important nutrition support practices but was not associated with improvements in clinical outcomes.
A validation study of depressive syndromes in Parkinson's disease

The validity, sensitivity, and specificity of depressive symptoms for the diagnosis of major depression, minor depression, dysthymic disorder, and subsyndromal depression in Parkinson's disease (PD) were examined. A consecutive series of 173 patients with PD attending a Movement Disorders Clinic underwent a comprehensive psychiatric and neurological assessment. The symptoms of loss of interest/pleasure, changes in appetite or weight, changes in sleep, low energy, worthlessness or inappropriate guilt, psychomotor retardation/agitation, concentration deficits, and suicide ideation were all significantly associated with the presence of the DSM‐IV depressed mood criterion for major depression. The symptoms of changes in appetite, changes in sleep, low energy, low self‐esteem, poor concentration, and hopelessness were all significantly associated with the presence of the DSM‐IV criterion of sad mood for dysthymic disorder. Thirty percent of our sample met DSM‐IV diagnostic criteria for major depression, 20% met diagnostic criteria for dysthymic disorder, 10% met diagnostic criteria for minor depression, and 8% met clinical criteria for subsyndromal depression. Patients with either major or minor depression had significantly more severe deficits in activities of daily living, more severe cognitive impairments, and more severe Parkinsonism than patients with either dysthymic disorder or no depression. This study provides validation to the DSM‐IV diagnostic criteria for major depression and dysthymic disorder for use in PD. The categories of minor and subsyndromal depression may need further validation. © 2007 Movement Disorder Society
Effect of the StuI polymorphism in the LDL receptor gene (Ala 370 to Thr) on lipid levels in healthy individuals

We have examined the effect on plasma lipid levels of a single base change in exon 8 of the LDL receptor gene that causes an amino acid change Ala 370 to Thr in a sample of 318 Icelandic individuals selected at random from the general population. The change destroys a StuI restriction site and was detected by digestion of pooled samples in groups of 5. The frequency of the loss of the cutting site was 0.05 (95%CI=0.014‐0.054). In men, those with the Thr allele (n=18) had 8.3% higher total cholesterol, 11.8% higher LDL cholesterol and 10.3% higher apolipoprotein B than those with the common Ala allele, whereas in women those with the Thr allele (n=12) had levels lower by 7.4%, 13.3% and 10.1% respectively. These differences reached statistical significance only in the men (p<0.05). Functional analysis of CHO cells transfected with constructs of the LDL receptor cDNA carrying the Ala370 and Thr370 alleles showed that within the limits of the assays there was no difference in function of the LDL receptor protein as measured by uptake and degradation of LDL. The data raise the possibility that amino acid substitutions that could affect LDL receptor function below the limits of detection by conventional assays, may have an effect on plasma lipid levels in the general population.
Bullying interventions: a binocular perspective.

INTRODUCTION Bullying is a complex relationship problem associated with many psychosocial difficulties for children who bully, as well as those who are victimized. A recent international volume of school-based bullying programs revealed modest effectiveness, highlighting the need to refine interventions using research on developmental profiles of children who bully and those who are victimized, as well as on their relationships. METHOD Based on developmental-systemic theory, a research review was conducted on individual and relationship risk factors associated with bullying and being victimized. RESULTS The review led to the proposal of two organizing principles for interventions: Scaffolding and Social Architecture. Scaffolding focuses on providing tailored and dynamic supports for the needs of individual children who bully or who are victimized. Social architecture requires that adults focus on the social dynamics of children's groups and create social contexts that promote positive peer interactions and dissipate contexts that foster negative interactions. CONCLUSION Interventions for bullying require a combination of scaffolding and social architecture to provide comprehensive supports and to change the social dynamics that enable bullying. With an empirically derived, comprehensive perspective, we may move closer to reducing the burden of these relationship problems in the lives of children and youth.
Randomized trial of doxycycline versus josamycin for Mediterranean spotted fever

We undertook a randomized clinical trial comparing therapeutic efficacy of the 1-day doxycycline regimen with the 5-day josamycin regimen for Mediterranean spotted fever. All 59 patients recovered uneventfully, and results did not significantly differ between the two schedules. One-day doxycycline therapy is an effective, easy, and inexpensive treatment. Josamycin is a useful therapeutic alternative that may be particularly convenient for pregnant women and patients with a history of allergy to tetracyclines.
Joint Design of limited feedback and multiuser precoding based on a precoding MSE metric

For the separation of the signals in the vector broadcast channel (BC), some information about the channel state is necessary at the transmitter. In many cases, this channel state information (CSI) must be fed back from the receivers to the transmitter. We jointly design the channel estimators and the quantizers at the receivers together with the precoder at the transmitter based on a precoder-centric criterion, i.e., the minimization of an MSE metric appropriate for the precoder design. This is in contrast to our previous work, where the quantizer design was based on a CSI-MSE metric. Interestingly, the estimators resulting from this joint formulation are independent of the used codebook. The codebook entries are the employed precoders. Therefore, each receiver feeds back the index of a set of precoders and the intersection of the sets gives the appropriate precoder. Since the quantizers of the different receivers have to work separately, the metric for the computation of the partition cells cannot be expressed as a simple squared error depending on the quantizer output. The proposed system based on a joint optimization clearly outperforms previous designs with separate optimization of feedback and precoding.
RF Linewidth in Monolithic Passively Mode-Locked Semiconductor Laser

We have analyzed theoretically and experimentally the linewidth of the first harmonic of the photocurrent (radio-frequency (RF) linewidth) in monolithic passively mode-locked semiconductor lasers. Due to the absence of restoring force, the timing jitter is directly related to the RF linewidth, avoiding possible underestimations made with conventional methods of phase noise measurement. The RF linewidth is also analytically related to the pulse characteristics using Haus's model. The timing stability performance of a promising two-section quantum-dot laser is presented using RF linewidth measurements. Experimental evolution of the RF linewidth with power and pulsewidth is finally compared to the analytical expression.
Using aided AAC models, recasts, and contrastive targets to teach grammatical morphemes to children who use AAC.

PURPOSE The purpose of the investigation was to evaluate the effects of using aided augmentative and alternative communication (AAC) modeling and recasting on the expression of grammatical morphemes with children who used AAC. METHOD A single-subject, multiple-probe, across-targets design was used for the study. Three participants were each taught to use 3 grammatical structures. Intervention consisted of aided AAC models and recasts during storybook reading tasks. RESULTS All three children readily began using the targeted grammatical morphemes. However, none of the participants maintained use of the first morpheme. Error analyses revealed that the children either omitted the targeted morpheme or replaced it with another morpheme. To address this issue, a second intervention phase was implemented for the targets that were not maintained. During this phase, various grammatical morphemes were contrasted with each other (e.g., past tense -ed vs. possessive 's). Following the second intervention phase, participants maintained all targets. CONCLUSIONS Aided AAC models and recasts may be used as part of intervention packages designed to help children acquire production of grammatical morphemes; however, it is important to provide contrasts of grammatical forms to ensure acquisition. Theoretical and clinical implications are discussed.