Miracle-dz/UniFAR-FTUs huggingface dataset:
LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell Proliferation

Objective— We recently demonstrated that low-density lipoprotein receptor–related protein 1 (LRP1) is required for cardiovascular development in zebrafish. However, what role LRP1 plays in angiogenesis remains to be determined. To better understand the role of LRP1 in endothelial cell function, we investigated how LRP1 regulates mouse retinal angiogenesis. Approach and Results— Depletion of LRP1 in endothelial cells results in increased retinal neovascularization in a mouse model of oxygen-induced retinopathy. Specifically, retinas in mice lacking endothelial LRP1 have more branching points and angiogenic sprouts at the leading edge of the newly formed vasculature. Increased endothelial proliferation as detected by Ki67 staining was observed in LRP1-deleted retinal endothelium in response to hypoxia. Using an array of biochemical and cell biology approaches, we demonstrate that poly(ADP-ribose) polymerase-1 (PARP-1) directly interacts with LRP1 in human retinal microvascular endothelial cells. This interaction between LRP1 and PARP-1 decreases under hypoxic condition. Moreover, LRP1 knockdown results in increased PARP-1 activity and subsequent phosphorylation of both retinoblastoma protein and cyclin-dependent kinase 2, which function to promote cell cycle progression and angiogenesis. Conclusions— Together, these data reveal a pivotal role for LRP1 in endothelial cell proliferation and retinal neovascularization induced by hypoxia. In addition, we demonstrate for the first time the interaction between LRP1 and PARP-1 and the LRP1-dependent regulation of PARP-1–signaling pathways. These data bring forth the possibility of novel therapeutic approaches for pathological angiogenesis.
Cephalopod research and bioactive substances

Marine environment comprises complex ecosystems and many of the organisms are known to possess bioactive components as a common means of self-defense or for the protection of eggs and embryos. In recent years, many bioactive compounds have been extracted, characterized and purified from various marine animals like bacteria, algae, dinoflagellates, tunicates, sponges, soft corals, bryozoans, cephalopods, and echinoderms. Present review consists of the research work done on the biology of the cephalopods, mainly pertaining to the feeding strategies (the salivary gland toxins, body and liver oils), the reproductive strategies (the ovarian-peptides, the nidamental gland products, accessory nidamental gland products and the associated symbiotic bacteria), and the defence mechanisms (the ink glands and their bioactive products, the squid-vibrio association, the camouflage colouration mechanisms and the reflectin-proteins). The learning capabilities and personalities of octopods have been a matter of great interest in cephalopod ethology. The aspect of cephalopod welfare in laboratory and field studies merits scientific debate because of the biological and behavioural complexities exhibited by these highly evolved, lovable invertebrates.
Activity-sensitive architectural power analysis

Prompted by demands for portability and low-cost packaging, the electronics industry has begun to view power consumption as a critical design criterion. As such there is a growing need for tools that can accurately predict power consumption early in the design process, many high-level power analysis models do not adequately model activity, however, leading to inaccurate results. This paper describes an activity-sensitive power analysis strategy for datapath, memory, control path, and interconnect elements. Since datapath and memory modeling has been described in a previous publication, this paper focuses mainly on a new Activity-Based Control (ABC) model and on a hierarchical interconnect analysis strategy that enables estimates of chip area as well as power consumption. Architecture-level estimates are compared to switch-level measurements based on net lists extracted from the layouts of three chips: a digital filter, a global controller, and a microprocessor. The average power estimation error is about 9% with a standard deviation of 10%, and the area estimates err on average by 14% with a standard deviation of 6%.
A novel method for adaptive determination clusters number based on N-order nearest neighbor

For problem of determining clusters number in K-Means, it was proposed a method for adaptively determining value of K based on N-order nearest-neighbor analysis. By calculation of N-order shortest distance between neighbors of various points, it was analyzed the distribution of current random sample data and get all step-points through numerical calculation to determine final K adaptively in case of lacking priori knowledge. Theoretical analysis and numerical simulation results show the effectiveness and reliability, it always has role of guidance for good results of clustering in K-Means.
The American College of Surgeons Commission on Cancer and the American The Growth and Maturation ofCancer Society the National Cancer Data Base

7 Pacific Northwest Cancer Foundation, Seattle, Washington; Northwest Hospital, Seattle, The authors thank the following cancer registry Washington. software providers who have cooperated with the NCDB and with other clinical information BACKGROUND. The National Cancer Data Base (NCDB), a joint project of the Comstudies of the Commission on Cancer: ACTUR, mission on Cancer of the American College of Surgeons and the American Cancer Alliance Medical Registry, AXIS Clinical SoftSociety, is a cancer management and outcomes data base for health care organizaware, CansurFACS, Cancer Surveillance System tions. It provides a comparative summary of patient care that is used by communiof Washington, CARTI, CMS, C/NET, C.S. Jones ties and participating hospitals for self-assessment. The most current (1994) data Group, ELM Services, Electronic Registry Sysare described here. tems, EUCAN, Genisys Systems, Healthcare Systems, Kentucky Cancer Patient Management METHODS. Six calls for data have yielded a total of 4,580,000 cases for the years System, Madison Information Technologies, 1985–1994. A total of 1735 hospital cancer registries have each participated in at Michigan Cancer Foundation, Micro-Net Data least one of the calls for data. Systems, Missouri Cancer Registry, Medical RESULTS. Summing the last year’s report from each of the 1227 hospitals that Registry Services, Nebraska Cancer Registry, participated in 1994, the cases represent the equivalent of 57% of the estimated New Mexico Tumor Registry, Onco Inc, Roches1994 U.S. cancer cases. These data were received from all six regions of the country, ter Regional Tumor Registry, Rocky Mountain Cancer Data System, STATCAN, TUMORS, State including all 50 states. Ninety-seven percent of patients received all or part of their Health Registry of Iowa, VA–Washington DC, treatment at the reporting hospital. The four most common cancers are carcinomas and the Uniform Data Standards Committee of of the breast (15.7%), lung (14.3%), prostate (13.1%), and colon (7.7%), and collecthe North American Association of Central Cantively they comprise a majority of new cases. cer Registries for its data standardization efCONCLUSIONS. The NCDB is a cancer management and outcomes data base for forts. health care organizations that currently provides data on 57% of the estimated
Students’ perceptions of instructor appropriateness and humor homophily

ABSTRACT Instructors use humor in the classroom in numerous ways, including behaving stupidly, offering impersonations, manipulating their nonverbals, telling a story, joke, or pun, and using a costume or prop. How students decode their instructors’ use of humor impacts their feelings about the course and their instructors. In this study, we investigated students’ (N = 306) perceptions of their humor homophily with their instructors, as well as their overall view of the appropriateness of the instructor’s classroom communication. Humor homophily was positively related to instructor humorousness, students’ affect for their instructor, and their likelihood of enrolling in another class with their instructor. We also found that the intensity of instructor humorousness’ relationship with student affect decreased when students perceived their instructor as appropriate. However, the more students found their instructors to be humorous and reported humor homophily, the more appropriate students rated their instructors’ communication.
A Appendix : Maximum Likelihood Estimation

Sproxil, Inc. is a company which produces PINs that manufacturers attach to products and which are then used by consumers to verify the authenticity of the product manufacturer. The goal of this work is to use existing PIN verification data provided by Sproxil to obtain a model for product shelf life: the length of time between PIN generation and product verification. We present several models that can be used to predict information about the shelf lives of various batches of products. We use maximum likelihood estimation to fit gamma distributions, which model the distributions of shelf lives. Cluster analysis is used to determine whether certain types of product batches have similar verification behavior. We find that the size of a product batch has an impact on how quickly verifications occur. Finally, regression analysis is used to find predictive relationships between variables related to shelf lives. We find that certain variables measuring how quickly the verification cycle begins are strong predictors of later stages in the verification cycle.
The NBTI Impact on RF Front End in Wireless Sensor Networks

The life time of RF front end in wireless sensor networks (WSN) is so important that it decides whether the whole system can work normally for a long time. Under CMOS technology, negative bias temperature instability (NBTI) is one of the most important factors that decide chips' life time. Especially with the feature size declining, NBTI effect is becoming more and more serious. Previous works mainly focus on NBTI effect at device level, or NBTI effect in large-scale digital circuits. In this paper, for the WSN node, we study the NBTI impact on the front- end circuits, such as voltage-controlled oscillators (VCO), charge pump (CP), low noise amplifier (LNA), and the whole transceiver system. The circuit level NBTI degeneration models are built for the key modules and the entire transceiver. The mathematical models can be summarized into a conclusion that the phase noise of the VCO will deteriorate, the current mismatch of the CP and the noise figure of the LNA will both increase, and then the sensitivity and adjacent channel selectivity (ACS) will be depressed by NBTI. Under HJTC 0.18-mum technology, our conclusions are proved by the simulation results.
Internal Mixture of Sea Salt, Silicates, and Excess Sulfate in Marine Aerosols

Individual aerosol particles from the remote marine atmosphere were investigated by scanning electron microscopy and electron microprobe analysis. A large fraction of the silicate mineral component of the aerosol was found to be internally mixed with sea-salt aerosol particles. This observation explains the unexpected similarity in the size distributions of silicates and sea salt that has been observed in remote marine aerosols. Reentrainment of dust particles previously deposited onto the sea surface and collision between aerosol particles can be excluded as possible source mechanisms for these internally mixed aerosols. The internal mixing could be produced by processes within clouds, including droplet coalescence. Cloud processes may also be responsible for the observed enrichment of excess (nonsea-salt) sulfate on sea-salt particles.
Inhaled Antibiotics in Cystic Fibrosis: A Review

OBJECTIVE: To provide an overview of aerosol drug therapy, including physical considerations and aerosol drug delivery systems, and to review clinical experience with inhaled antibiotics in cystic fibrosis (CF) when used as adjunctive therapy to intravenous therapy for acute pulmonary exacerbations and chronic, suppressive therapy. DATA SOURCES: A MEDLINE search (1966-1995) of English-language literature describing the use of inhaled antibiotics for the management of CF. STUDY SELECTION AND DATA EXTRACTION: All articles were considered for possible inclusion in the review. Pertinent information as judged by the authors was selected for discussion. DATA SYNTHESIS: The use of inhaled antibiotics as adjunctive therapy to systemic therapy for acute exacerbations did not improve pulmonary function tests, increase hospital discharge rate, or permanently eradicate sputum Pseudomonas. Clinical trials of inhaled antibiotics as suppressive therapy yielded variable results. Individually, four trials documented a significant improvement in pulmonary function, three trials documented a slower decline in pulmonary function, and four trials reported a reduced frequency of hospitalizations. However, the trials were unable to collectively document a prolonged beneficial effect of inhaled antibiotics on pulmonary function, sputum bacterial density, and frequency of hospitalizations. CONCLUSIONS: Clinical trials conducted thus far suggest no role for inhaled antibiotics in the treatment of acute pulmonary exacerbations in patients with CF. Aerosolized antibiotics used as suppressive therapy may be useful in certain patients, but their use should be limited to select patients based on individual response to therapy. Additional long-term, well-controlled trials of inhaled antibiotics as suppressive therapy are needed before routine use can be recommended.
Strategic human resources: a new source for competitive advantage in the global arena

As demands are made on organizations to expand their global markets, having an effective global human resources function becomes imperative. Based on interviews with global human resource executives in sixty of the largest US-based multinational organizations, this study first identifies ten factors, or guiding principles, that facilitate such effectiveness. Using data from surveys of these HR executives as well as of managers of non-HR areas and the CEOs/business unit executives of these companies, the paper then analyses how the members of these various groups rated the effectiveness of the global HR function. The survey findings demonstrate that the global HR executives and the CEO/business unit executives rated the global HR function relatively high, while the executives in the other functional areas rated its effectiveness somewhat low. The relationship between the effectiveness of the global HR function and firm performance was also examined and revealed that three of the ten factors identified by t.
Smoking and Risk for Acute Pancreatitis: A Systematic Review and Meta-Analysis

Abstract We aimed to better understand the relationship between smoking and a risk for acute pancreatitis (AP) in existing observational studies. We identified studies by searching the PubMed, Scopus, and Web of Science databases (from inception through August 31, 2013) and by searching bibliographies of relevant articles. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated with fixed-effects and random-effects models. A total of 5 studies met inclusion criteria for analysis. Both current smoking (summary RR, 1.74; 95% CI, 1.39–2.17; n = 5 studies) and former smoking (summary RR, 1.32; 95% CI, 1.03–1.71; n = 4 studies) were associated with an increased risk for AP. The positive association of current smoking and risk for AP remained when we limited the meta-analysis to studies that controlled for alcohol intake and body mass index (summary RR, 1.76; 95% CI, 1.31–2.36; n = 4 studies). Both current and former smoking are associated with increased risk for AP. Further investigations, both epidemiological and mechanistic, are needed to establish the extent to which the association can be explained by a causal link and whether smoking cessation can prevent the occurrence and development of AP.
Protein structure validation by generalized linear model root‐mean‐square deviation prediction

Large‐scale initiatives for obtaining spatial protein structures by experimental or computational means have accentuated the need for the critical assessment of protein structure determination and prediction methods. These include blind test projects such as the critical assessment of protein structure prediction (CASP) and the critical assessment of protein structure determination by nuclear magnetic resonance (CASD‐NMR). An important aim is to establish structure validation criteria that can reliably assess the accuracy of a new protein structure. Various quality measures derived from the coordinates have been proposed. A universal structural quality assessment method should combine multiple individual scores in a meaningful way, which is challenging because of their different measurement units. Here, we present a method based on a generalized linear model (GLM) that combines diverse protein structure quality scores into a single quantity with intuitive meaning, namely the predicted coordinate root‐mean‐square deviation (RMSD) value between the present structure and the (unavailable) “true” structure (GLM‐RMSD). For two sets of structural models from the CASD‐NMR and CASP projects, this GLM‐RMSD value was compared with the actual accuracy given by the RMSD value to the corresponding, experimentally determined reference structure from the Protein Data Bank (PDB). The correlation coefficients between actual (model vs. reference from PDB) and predicted (model vs. “true”) heavy‐atom RMSDs were 0.69 and 0.76, for the two datasets from CASD‐NMR and CASP, respectively, which is considerably higher than those for the individual scores (−0.24 to 0.68). The GLM‐RMSD can thus predict the accuracy of protein structures more reliably than individual coordinate‐based quality scores.
Power performance analysis of compensated Cascaded Integrator Comb (CIC) filter in optimum computing

Decimation filter has wide application in both the analog and digital system for data rate conversion as well as filtering. This paper presents efficient compensated Cascaded Integrator Comb (CIC) decimation filter to improve the passband of interest using redundant signed digit arithmetic with its power analysis. Signed digit (SD) number systems provide the possibility of constant-time addition, where inter digit carry propagation is eliminated. A hybrid adder can add an unsigned number to a signed-digit number and hence their efficient performance greatly determines the quality of the final output of the concerned circuit. With the development of high speed processors, a tradeoff is always required between area and execution time to yield the most suitable implementation with low power consumption. The proposed work analyzed the power performance of compensated CIC decimation filter with decimation factor 64 on the bases of its On-chip leakage power and dynamic power with the variation of word length in narrow band and wide band filtering. This paper also utilized signed digit (SD) algorithm to incorporate the key features of the conventional number system with a signed digit (SD) to improve the addition time with high power constraints in an optimized fashion. CIC decimation filter with SD algorithm shows a 63.68% and 39.65% gate delay × dynamic power improvement relative to RCA and HSD fast adder algorithm respectively.
Ethical perceptions of newly staffed accountants : an exploratory study

The current economic crisis coupled with corporate scandals may have impacted the future leadership of newly staffed accountants. As a result, it may be of some benefit to see if the ethical perceptions among newly staffed accountants were affected by the unethical decisionmaking of some key corporate leaders. The purpose of this study therefore, was to explore the ethical perceptions among newly staffed accountants in light of the unethical behaviors of some corporate leaders. This study explores the stages of the theory of moral development by Lawrence Kohlberg using Victor and Cullen’s Ethical Climate Questionnaire (ECQ). Approximately 75 newly staffed accountants were surveyed. Findings suggest that newly staffed accountants surveyed in this paper can be used to improve both academia and corporate training.
An integrated potentiostat sensor with digitally-controlled input-parasitic compensation for nanopore applications

This paper presents an integrated low-power and low-noise potentiostat sensor for nanopore sensing. This high-sensitivity sensor consists of four stages: a preamplifier, a difference amplifier, a unity-gain buffer and a capacitive compensation unit. For the preamplifier, a resistive-feedback transimpedance amplifier with 50MΩ is used to detect an ionic current variation and the difference amplifier then provides a programmable voltage gain. The compensation block works to cancel out the input-parasitic capacitance effect, which causes a dead-time during nanopore sensing, as well as estimate it along with the control unit. For high-throughput nanopore sensing, in this work, a potentiostat sensor is designed and simulated in a 0. 35μm CMOS process.
The role of the taxanes in the management of metastatic breast cancer

Evidence-based Series (EBS) 1-3 EDUCATION AND INFORMATION 2010, the resulting review report, consists of the following 4 parts: 1. Guideline Overview 2. Summary 3. Full Report 4. Document Assessment and Review Tool and is available on the CCO website (http://www.cancercare.on.ca) PEBC Breast Cancer Disease Site Group page at: http://www.cancercare. on.ca/toolbox/qualityguidelines/diseasesite/breast-ebs/.
Mesh modification for evolution equations

Finite element methods for which the underlying function spaces change with time are studied. The error estimates produced are all in norms that are very naturally associated with the problems. In some cases the Galerkin solution error can be seen to be quasi-optimal. K. Miller's moving finite element method is studied in one space dimension; convergence is proved for the case of smooth solutions of parabolic problems. Most, but not all, of the analysis is done on linear problems. Although second order parabolic equations are emphasized, there is also some work on first order hyperbolic and Sobolev equations.
Juego de ontología que propaga activamente evaluaciones de usuarios a través de ontologías superiores

Ontology matching is a complex and largely user-driven process of finding correspondences between entities belonging to different ontologies. Many algorithms have been proposed to automate the matching generation. However, they can’t be fully automated since the user input is required to accept, reject, or create new alignments or matchings. This paper extends on active learning framework for ontology matching, which tries to find the most informative candidate matches to query the user. In our approach the user’s feedback exploits upper ontologies as semantic bridges. Such bridges contribute to the overall matching process while considering the supervised information and its propagation in correcting mistake matchings. In the experimentation our work outperformed the previous version where none upper ontology was used, while it remains as competitive as state of the art ontology matching system.