Miracle-dz/UniFAR-FTUs huggingface dataset:
Contributions of Intraindividual and Interindividual Differences to Multisensory Processes

Abstract Most evidence on the neural and perceptual correlates of sensory processing derives from studies that have focused on only a single sensory modality and averaged the data from groups of participants. Although valuable, such studies ignore the substantial interindividual and intraindividual differences that are undoubtedly at play. Such variability plays an integral role in both the behavioral/perceptual realms and in the neural correlates of these processes, but substantially less is known when compared with group-averaged data. Recently, it has been shown that the presentation of stimuli from two or more sensory modalities (i.e., multisensory stimulation) not only results in the well-established performance gains but also gives rise to reductions in behavioral and neural response variability. To better understand the relationship between neural and behavioral response variability under multisensory conditions, this study investigated both behavior and brain activity in a task requiring participants to discriminate moving versus static stimuli presented in either a unisensory or multisensory context. EEG data were analyzed with respect to intraindividual and interindividual differences in RTs. The results showed that trial-by-trial variability of RTs was significantly reduced under audiovisual presentation conditions as compared with visual-only presentations across all participants. Intraindividual variability of RTs was linked to changes in correlated activity between clusters within an occipital to frontal network. In addition, interindividual variability of RTs was linked to differential recruitment of medial frontal cortices. The present findings highlight differences in the brain networks that support behavioral benefits during unisensory versus multisensory motion detection and provide an important view into the functional dynamics within neuronal networks underpinning intraindividual performance differences.
Video Retrieval for Multimedia Verification of Breaking News on Social Networks

This paper presents an approach to automatically detecting breaking news events from social media streams, using event detection to collect in near real time relevant video documents from social networks regarding that breaking news. A visual analytics dashboard provides access to the results of the content processing pipeline, providing a rich interactive interface to explore emerging stories and select video material around those stories for verification.
Abstracts of randomized controlled trials presented at the society for pediatric research meeting: an example of publication bias.

BACKGROUND Publication bias toward studies that favor new therapies has been known to occur for the past 40 years, yet its implications are not well studied in child health. The increased interest in meta-analyses has highlighted the need to identify the totality of evidence when addressing treatment questions. OBJECTIVES To measure the percentage of randomized controlled trials (RCTs) presented at a major pediatric scientific meeting that were subsequently published as full-length articles, to investigate factors associated with publication, and to describe the variables that change from abstract to manuscript form. DESIGN The scientific proceedings from the Society for Pediatric Research were hand searched for RCTs (1992-1995). Subsequent publication was ascertained through a search of various electronic databases. Quality of abstracts and manuscripts was measured, and data were extracted using a structured form. RESULTS A total of 264 (59.1%) of 447 abstracts were subsequently published. Almost 64% of RCTs that were subsequently published favored new therapy compared with 43.5% of studies that were never published (P<.001). Mean effect size for published vs unpublished RCTs was 0.74 vs 0.05 (P<.001). Median sample size was larger in published (n = 45) vs unpublished (n = 34) RCTs (P =.02). Quality was significantly lower for abstracts vs published RCTs (P<.001). For 5% of abstracts that were subsequently published, the conclusion regarding treatment efficacy changed. CONCLUSIONS Publication bias is a serious threat to assessing the effectiveness of interventions in child health, as little more than half of RCTs presented at a major scientific meeting are subsequently published. There is a need to institute an international registry of RCTs in children so that the totality of evidence can be accessed when assessing treatment effectiveness.
The rise of a novel classification system for endometrial carcinoma; integration of molecular subclasses

Endometrial cancer is a clinically heterogeneous disease and it is becoming increasingly clear that this heterogeneity may be a function of the diversity of the underlying molecular alterations. Recent large‐scale genomic studies have revealed that endometrial cancer can be divided into at least four distinct molecular subtypes, with well‐described underlying genomic aberrations. These subtypes can be reliably delineated and carry significant prognostic as well as predictive information; embracing and incorporating them into clinical practice is thus attractive. The road towards the integration of molecular features into current classification systems is not without obstacles. Collaborative studies engaging research teams from across the world are working to define pragmatic assays, improve risk stratification systems by combining molecular features and traditional clinicopathological parameters, and determine how molecular classification can be optimally utilized to direct patient care. Pathologists and clinicians caring for women with endometrial cancer need to engage with and understand the possibilities and limitations of this new approach, because integration of molecular classification of endometrial cancers is anticipated to become an essential part of gynaecological pathology practice. This review will describe the challenges in current systems of endometrial carcinoma classification, the evolution of new molecular technologies that define prognostically distinct molecular subtypes, and potential applications of molecular classification as a step towards precision medicine and refining care for individuals with the most common gynaecological cancer in the developed world. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
FPGA based one-cycle control of multilevel cascaded H-Bridge inverter

This paper presents One-Cycle Control (OCC) of nine-level cascaded H-bridge inverter implemented in Altera FPGA Cyclone-III. The OCC, being a nonlinear technique, overcomes some problems related to nonlinear nature of switching power converters, thus allowing fast dynamic response and robustness to power source and load perturbations. An optimum power sharing strategy, among different modules of the multilevel inverter, is also presented that equalizes power sharing at the each H-bridge. After a description of the system some simulation results obtained in ModelSim are presented showing the effectiveness of the OCC which follows the reference signal, sinusoidal, in a concrete manner with the capability of regaining steady-state in just one switching cycle. There is neither dynamic error or steady-state error between the reference signal and the switched output.
Mental health among children and adolescents: Construct validity, reliability, and parent-adolescent agreement on the ‘Strengths and Difficulties Questionnaire’ in Chile

The Strengths and Difficulties Questionnaire (SDQ) is a screening tool used to measure psychological functioning among children and adolescents. It has been extensively used worldwide, but its psychometric properties, such as internal structure and reliability, seem to vary across countries. This is the first study exploring the construct validity and reliability of the Spanish version of SDQ among early adolescents (self-reported) and their parents in Latin America. A total of 1,284 early adolescents (9–15 years) and their parents answered the SDQ. We also collected demographic variables. A confirmatory factor analysis was conducted to assess the latent structure of the SDQ. We also used the multitrait-multimethod analysis to separate the true variance on the constructs from variance resulting from measurement methods (self-report vs. parent report), and evaluated the agreement between adolescents and their parents. We found that the original five-factor model was a good solution and the resulting sub-scales had good internal consistency. We also found that the self-reported and parental versions of SDQ provide different information, which are complementary and provide a better picture of the emotional, social, and conduct problems of adolescents. We have added evidence for the construct validity and reliability of the Spanish self-reported and parental SDQ versions in a Chilean sample.
An overview of the clinical management of cyclic vomiting syndrome in childhood

Abstract This narrative review provides an update on cyclic vomiting syndrome pathogenesis, diagnosis and management, based upon studies published after the 2008 North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) official recommendations. The review began with a comprehensive PubMed/Medline search for “cyclic vomiting syndrome”, “periodic syndromes” and “pediatrics” from 2000 up to October 2017. Additional papers were identified by reviewing the re-ference lists of retrieved publications. Cyclic vomiting syndrome is a severe, debilitating disorder of the brain–gut axis with unclear pathogenesis, that significantly affects long-term quality of life of affected children and their families. The 2008 NASPGHAN recommendations defined the major clinical, diagnostic and therapeutic peculiarities. Over the last 10 years, advancements in pathogenesis and diagnostic criteria have been made, and new prophylactic and therapeutic strategies have been proposed. These aspects are discussed in this manuscript. For the pediatrician, the major aim is to have early clinical suspicion to avoid diagnostic delay and to start adequate, phase-related, symptom-tailored management.
Influence of the ProTaper™ Gutta-percha master point diameter in the apical sealing

© Copyright 2008, CIC Edizioni Internazionali, Roma. Carlos Menezes Aguiar Michelle Corrêa de Araújo Coêlho Luciana Sette Santos Clímaco Andréa Cruz Câmara Federal University of Pernambuco, Recife, Brazil Faculty of Dentistry Department of Prosthetics and Oral and Facial Surgery Corrispondenza: Prof. Carlos Menezes Aguiar Rua Heitor Maia Filho, 52 Apt. 201 Madalena, Recife PE 50750-525 Brasil Telefone: (+55) 81 3467 6821 E-mail: cmaguiar@ufpe.br
Minimally Actuated Transformation of Origami Machines

Origami-inspired machines are a promising approach to robotic transformation. In this letter, we present a new method for transformation that uses dynamic response to change the mountain–valley fold pattern. We propose a dynamic model and validate it through experimental characterization of sample mechanisms. We demonstrate that these mechanisms reliably change their dynamic behavior at a discrete switching frequency, and this frequency can be changed by varying the stiffness and mass of the mechanism. This indicates that mechanisms can be designed to respond to different frequencies and selectively transform from a global input. We demonstrate a three-fingered gripping mechanism with a single actuator that can transform between four nontrivial configurations. We believe that this approach can be applied to several types of origami structures.
Numerical modelling of magma dynamics coupled to tectonic deformation of lithosphere and crust

Many unresolved questions in geodynamics revolve around the physical behaviour of the two-phase system of a silicate melt percolating through and interacting with a tectonically deforming host rock. Well-accepted equations exist to describe the physics of such systems and several previous studies have successfully implemented various forms of these equations in numerical models. To date, most such models of magma dynamics have focused on mantle flow problems and therefore employed viscous creep rheologies suitable to describe the deformation properties of mantle rock under high temperatures and pressures. However, the use of such rheologies is not appropriate to model melt extraction above the lithosphere–asthenosphere boundary, where the mode of deformation of the host rock transitions from ductile viscous to brittle elasto-plastic. Here, we introduce a novel approach to numerically model magma dynamics, focusing on the conceptual study of melt extraction from an asthenospheric source of partial melt through the overlying lithosphere and crust. To this end, we introduce an adapted set of two-phase flow equations, coupled to a visco-elasto-plastic rheology for both shear and compaction deformation of the host rock in interaction with the melt phase. We describe in detail how to implement this physical model into a finite-element code, and then proceed to evaluate the functionality and potential of this methodology using a series of conceptual model setups, which demonstrate the modes of melt extraction occurring around the rheological transition from ductile to brittle host rocks. The models suggest that three principal regimes of melt extraction emerge: viscous diapirism, viscoplastic decompaction channels and elasto-plastic dyking. Thus, our model of magma dynamics interacting with active tectonics of the lithosphere and crust provides a novel framework to further investigate magmato-tectonic processes such as the formation and geometry of magma chambers and conduits, as well as the emplacement of plutonic rock complexes.
Generalized Binary Search For Split-Neighborly Problems

In sequential hypothesis testing, Generalized Binary Search (GBS) greedily chooses the test with the highest information gain at each step. It is known that GBS obtains the gold standard query cost of $O(\log n)$ for problems satisfying the $k$-neighborly condition, which requires any two tests to be connected by a sequence of tests where neighboring tests disagree on at most $k$ hypotheses. In this paper, we introduce a weaker condition, split-neighborly, which requires that for the set of hypotheses two neighbors disagree on, any subset is splittable by some test. For four problems that are not $k$-neighborly for any constant $k$, we prove that they are split-neighborly, which allows us to obtain the optimal $O(\log n)$ worst-case query cost.
History of psychosis and mania, and outcomes after kidney transplantation ‐ a retrospective study

History of psychosis or mania, if uncontrolled, both represent relative contraindications for kidney transplantation. We examined 3680 US veterans who underwent kidney transplantation. The diagnosis of history of psychosis/mania was based on a validated algorithm. Measured confounders were used to create a propensity score‐matched cohort (n = 442). Associations between pretransplantation psychosis/mania and death with functioning graft, all‐cause death, graft loss, and rejection were examined in survival models and logistic regression models. Post‐transplant medication nonadherence was assessed using proportion of days covered (PDC) for tacrolimus and mycophenolic acid in both groups. The mean ± SD age of the cohort at baseline was 61 ± 11 years, 92% were male, and 66% and 27% of patients were white and African‐American, respectively. Compared to patients without history of psychosis/mania, patients with a history of psychosis/mania had similar risk of death with functioning graft [subhazard ratio (SHR) (95% confidence interval (CI)): 0.94(0.42–2.09)], all‐cause death [hazard ratio (95% CI): 1.04 (0.51–2.14)], graft loss [SHR (95% CI): 1.07 (0.45–2.57)], and rejection [odds ratio(95% CI): 1.23(0.60–2.53)]. Moreover, there was no difference in immunosuppressive drug PDC in patients with and without history of psychosis/mania (PDC: 76 ± 21% vs. 78 ± 19%, P = 0.529 for tacrolimus; PDC: 78 ± 17% vs. 79 ± 18%, P = 0.666 for mycophenolic acid). After careful selection, pretransplantation psychosis/mania is not associated with adverse outcomes in kidney transplant recipients.
Increased FXYD1 and PGC‐1α mRNA after blood flow‐restricted running is related to fibre type‐specific AMPK signalling and oxidative stress in human muscle

This study explored the effects of blood flow restriction (BFR) on mRNA responses of PGC‐1α (total, 1α1, and 1α4) and Na+,K+‐ATPase isoforms (NKA; α1‐3, β1‐3, and FXYD1) to an interval running session and determined whether these effects were related to increased oxidative stress, hypoxia, and fibre type‐specific AMPK and CaMKII signalling, in human skeletal muscle.
Effects of rhBMP-2 gene transfection to periodontal ligament cells on osteogenesis

The present study aims to investigate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the osteogenesis of periodontal ligament (PDL) cells. The expression vector of rhBMP-2 (pcDNA3.1-rhBMP-2) was established. PDL cells were obtained through the enzymatic digestion and tissue explant methods and verified by immunohistochemistry. Cells were classified into experimental (cells transfected with pcDNA3.1/rhBMP-2-EGFP), blank (cells with no transfection) and control group (cells transfected with empty plasmid). rhBMP-2 expression was assessed via Western blotting analysis. The mineralization ability, alkaline phosphatase (ALP) activity and level of related osteogenic biomarkers were detected to evaluate the osteogenic characteristics of PDL cells. The rhBMP-2 expression vector (pcDNA3.1-rhBMP-2) was successfully established. Primary PDL cells displayed a star or long, spindle shape. The cultured cells were long, spindle-shaped, had a plump cell body and homogeneous cytoplasm and the ellipse nucleus contained two or three nucleoli. Cells displayed a radial, sheaf-like or eddy-like arrangement after adherence growth. Immunohistochemical staining confirmed that cells originated from mesenchymal opposed to epithelium. The experimental group exhibited an enhanced mineralization ability, higher ALP activity and increased expression of rhBMP-2 and osteogenic biomarkers (Runx2, collagen type I and osteocalcin) than the blank and control group. The present study demonstrated that rhBMP-2 transfection enhances the osteogenesis of PDL cells and provides a possibility for the application of rhBMP-2 expression products in dental disease treatment.
A Compact Magnetic Field-Based Obstacle Detection and Avoidance System for Miniature Spherical Robots

Due to their efficient locomotion and natural tolerance to hazardous environments, spherical robots have wide applications in security surveillance, exploration of unknown territory and emergency response. Numerous studies have been conducted on the driving mechanism, motion planning and trajectory tracking methods of spherical robots, yet very limited studies have been conducted regarding the obstacle avoidance capability of spherical robots. Most of the existing spherical robots rely on the “hit and run” technique, which has been argued to be a reasonable strategy because spherical robots have an inherent ability to recover from collisions. Without protruding components, they will not become stuck and can simply roll back after running into bstacles. However, for small scale spherical robots that contain sensitive surveillance sensors and cannot afford to utilize heavy protective shells, the absence of obstacle avoidance solutions would leave the robot at the mercy of potentially dangerous obstacles. In this paper, a compact magnetic field-based obstacle detection and avoidance system has been developed for miniature spherical robots. It utilizes a passive magnetic field so that the system is both compact and power efficient. The proposed system can detect not only the presence, but also the approaching direction of a ferromagnetic obstacle, therefore, an intelligent avoidance behavior can be generated by adapting the trajectory tracking method with the detection information. Design optimization is conducted to enhance the obstacle detection performance and detailed avoidance strategies are devised. Experimental results are also presented for validation purposes.
Nerve Conduction Blockade in the Sciatic Nerve Prevents but Does Not Reverse the Activation of p38 Mitogen-activated Protein Kinase in Spinal Microglia in the Rat Spared Nerve Injury Model

Background: Current evidence indicates that p38 mitogen-activated protein kinase activation in spinal microglia contributes to the development of neuropathic pain. However, how nerve injury activates p38 in spinal microglia is incompletely unknown. Nerve injury–induced ectopic spontaneous activity is essential for the generation of neuropathic pain. The authors examined whether peripheral neural activity is necessary for p38 activation in spinal microglia. Methods: To examine whether spinal microglia activation depends on peripheral activity in the rat spared nerve injury (SNI) model, the authors blocked conduction in the sciatic nerve before or 2 days after SNI. The block was produced by applying bupivacaine-loaded microspheres above the nerve injury site. The p38 activation was examined by p38 phosphorylation using a phosphorylated p38 antibody, and neuropathic pain-related behavior was evaluated before and after intrathecal infusion of a p38 inhibitor. Results: Three days after SNI, there was a marked p38 activation in the medial two thirds of the dorsal horn, where the injured tibial and peroneal nerves terminated and where isolectin B4 staining was lost. Phosphorylated p38 was only colocalized with the microglial surface marker OX-42, indicating a microglial localization of phosphorylated p38 in the SNI model. Bupivacaine microspheres produced persistent block (loss of sensory and motor function) of the sciatic nerve for the whole period of the study (3 days). This blockade prevented but did not reverse p38 activation in spinal microglia. Intrathecal infusion of the p38 inhibitor FR167653 prevented and reversed mechanical allodynia on post-SNI day 3. Conclusions: After nerve injury, activity in the peripheral nerve is required for the induction but not the maintenance of p38 activation in spinal microglia.