Miracle-dz/UniFAR-FTUs huggingface dataset:
Mutations foncières et urbaines pour la production des espaces et des équipements publics dans la ville grecque moderne : les propriétés de l'Armée et de l'Université et la formation de l'espace urbain de Thessalonique de 1912 jusqu'à nos jours

La these explore le role des grands detenteurs de la propriete fonciere publique (Armee, Universite, Societe Fonciere Publique: autres grands organismes nationaux ou institutions) a la production de l'espace urbain en Grece. L'objet de la recherche est de comprendre la maniere dont la gestion de differentes categories de la propriete fonciere publique par ses detendeurs/gestionnaires a influence et continue a influencer la forme de l'espace urbain, ainsi que le processus et les mecanismes de production des espaces et equipements publics. La ville de Thessalonique constitue un terrain de recherche empirique privilegie: a cause de sa situation geographique et des conditions historiques le phenomene d'occupation des grands terrains en milieu urbain par des proprietaires institutionnels a un impact important et visible dans le tissu urbain. L'integration de la ville en 1912 au nouvel Etat grec est choisie comme point de depart a mesure qu'elle constitue un tournant dans l'histoire et l'evolution de la ville. Sont explores les themes suivants: Sur le plan national, l'evolution du cadre de production des espaces et equipements publics, le role de la propriete publique a leur production a travers l'etude des exemples concrets, ainsi que les politiques et structures de gestion de la propriete fonciere publique. Sur le plan local, le role de deux grands proprietaires institutionnels et de la gestion de leurs terrains a la fabrication de l'espace urbain: l'Universite, proprietaire qui s'etend au fur et a mesure que ses besoins augmentent et l'Armee, proprietaire qui se retire graduellement en «concedant » ses terrains aux autres fonctions urbaines publiques.
Complete Genome Sequence of Bacillus cereus Bacteriophage vB_BceS_KLEB30-3S

In this study, we present the genomic characterization of the temperate bacteriophage vB_BceS_KLEB30-3S (KLEB30-3S), which was induced from Bacillus cereus strain KR3M-30, isolated from a gypsum karst lake ecosystem in Lithuania. The 37,134-bp genome of KLEB30-3S contains 58 predicted protein-encoding genes and no tRNA genes. ABSTRACT In this study, we present the genomic characterization of the temperate bacteriophage vB_BceS_KLEB30-3S (KLEB30-3S), which was induced from Bacillus cereus strain KR3M-30, isolated from a gypsum karst lake ecosystem in Lithuania. The 37,134-bp genome of KLEB30-3S contains 58 predicted protein-encoding genes and no tRNA genes.
Identification and characterization of single nucleotide polymorphisms in 6 growth-correlated genes in porcine by denaturing high performance liquid chromatography

The growth-correlated genes that are part of the neuroendocrine growth axis play crucial roles in the regulation of growth and development of pig. The identification of genetic polymorphisms in these genes will enable the scientist to evaluate the biological relevance of such polymorphisms and to gain a better understanding of quantitative traits like growth. In the present study, seven pairs of primers were designed to obtain unknown sequences of growth-correlated genes, and other 25 pairs of primers were designed to identify single nucleotide polymorphisms (SNP) using the denaturing high-performance liquid chromatography (DHPLC) technology in four pig breeds (Duroc, Landrace, Lantang and Wuzhishan), significantly differing in growth and development characteristics. A total of 101 polymorphisms were discovered in 10,707 base pairs (bp) from six genes of the ghrelin (GHRL), leptin (LEP), insulin-like growth factor II (IGF-II), insulin-like growth factor binding protein 2 (IGFBP-2), insulin-like growth factor binding protein 3 (IGFBP-3), and somatostatin (SS). The observed average distances between the SNP in the 5′UTR, coding regions, introns and 3′UTR were 134, 521, 81 and 92 bp, respectively. Four SNPs were found in the coding regions of IGF-II, IGFBP-2 and LEP, respectively. Two synonymous mutations were obtained in IGF-II and LEP genes respectively, and two non-synonymous were found in IGFBP-2 and LEP genes, respectively. Seven other mutations were also observed. Thirty-two PCR–RFLP markers were found among 101 polymorphisms of the six genes. The SNP discovered in this study would provide suitable markers for association studies of candidate genes with growth related traits in pig.
A Single-Chip Ultra-Wideband Receiver With Silicon Integrated Antennas for Inter-Chip Wireless Interconnection

A single-chip ultra-wideband (UWB) receiver was developed using 0.18 mum CMOS technology, and inter-chip wireless data communication by integrated antennas was confirmed. Timing pulse and data pulse with on-off keying were alternately sent from a transmitting antenna. Double Gaussian monocycle pulse (GMP) template generators performed detections of timing and data pulses. A single GMP template, whose probability distribution of the pulse repetition cycle is given by Gaussian, showed a random jitter of 4.87 ps. Dual-Dirac model could explain the probability distribution of the cycle of double GMP template. Obtained random jitter and deterministic jitter were 4.6 ps and 14.4 ps, respectively. The receiver successfully recovered 200 Mbps data at the distance of 0.5 mm.
‘We lost because of his drunkenness’: the social processes linking alcohol use to self-harm in the context of daily life stress in marriages and intimate relationships in rural Sri Lanka

Introduction Harmful alcohol use has been found to cause detriment to the consumers and those around them. Research carried out in Sri Lanka has described the socioeconomic consequences to families owing to alcohol consumption. However, the social processes around alcohol use and how it could result in behaviour such as self-harm was unclear. With an outset in daily life stressors in marriages and intimate relationships we explored alcohol use in families with a recent case of self-harm. Methods Qualitative data were collected for 11 months in 2014 and 2015 in the North Central and North Western provinces of Sri Lanka. Narrative life story interviews with 19 individuals who had self-harmed where alcohol was involved and 25 of their relatives were conducted. Ten focus group discussions were carried out in gender and age segregated groups. An inductive content analysis was carried out. Results Participants experienced two types of daily life stressors: non-alcohol-related stressors, such as violence and financial difficulties, and alcohol-related stressors. The alcohol-related stressors aggravated the non-alcohol-related daily life stressors within marriages and intimate relationships, which resulted in conflict between partners and subsequent self-harm. Women were disproportionately influenced by daily life stressors and were challenged in their ability to live up to gendered norms of marriage. Further, women were left responsible for their own and their husband’s inappropriate behaviour. Self-harm appeared to be a possible avenue of expressing distress. Gendered alcohol and marriage norms provided men with acceptable excuses for their behaviour, whether it was alcohol consumption, conflicts or self-harm. Conclusions This study found that participants experienced both alcohol-related and non-alcohol-related daily life stressors. These two categories of daily life stressors, gender inequalities and alcohol norms should be considered when planning alcohol and self-harm prevention in this setting. Life situations also reflected larger community and structural issues.
Brain angiotensin II: new insights into its role in sympathetic regulation.

Since its discovery, the renin-angiotensin II system (RAS) has intrigued physiologists and clinicians.1 Angiotensin II (Ang II), an ancient peptide, evolved to carry out a variety of biological functions, in order to meet the needs of diverse organisms. The negative feedback nature of the RAS enables it to participate in hemodynamic, endocrine, neural, behavioral, and excretory functions. It is truly a peptide to which the survival of most species is closely linked. Over the past 20 years, blockade of the RAS has become a prime target for pharmacotherapy in a variety of diseases. Either blockade of Ang I conversion to Ang II or blockade of the Ang II type 1 receptor (AT1) has been used to treat hypertension and heart failure.2–4⇓⇓ Administration of these agents are effective in ameliorating disease and enhancing survival, even in patients without augmented levels of circulating Ang II. This observation has led investigato0rs to focus on the tissue RAS as a mechanism by which organ function is both controlled and, in disease states, impaired. Although the kidney is the only organ that stores renin in granular form, the components of the RAS have been found in tissues from several other organs. These include the heart, liver, lung, and brain.5–7⇓⇓ The regulation of the RAS system in the brain is especially intriguing because Ang II can act as both a neurotransmitter and a vasoconstrictor. It has been known for some time that the brain expresses the genes that code for angiotensinogen, renin, converting enzyme, and …
Effects of Aging and a High Fat Diet on Body Weight and Glucose Tolerance in Glucagon-Like Peptide-1 Receptor-/- Mice.

Disruption of glucagon-like peptide-1 (GLP-1) receptor signaling in mice results in mild glucose intolerance, principally due to elimination of the incretin effect of GLP-1. Despite the inhibitory effects of GLP-1 on food intake, 6- to 8-week-old GLP-1 receptor -/-(GLP-1R-/-) mice were not obese and did not exhibit disturbances of feeding behavior. As both diabetes and obesity frequently become more phenotypically evident in older rodents, we studied the consequences of aging and a high fat diet on glucose control and body weight in GLP-1R-/- mice. No evidence of obesity or deterioration in glucose control was detected in 11- and 16-month-old GLP-1R-/- mice (mean weight, 34.7 +/- 2.0, 30.5 +/- 1.5, and 34.6 +/- 2.8 g in male and 25.3 +/-1.6, 28.4 +/-1.2, and 31.9 +/- 2.9 g in female GLP-1R+/+, GLP-1R+/-, and GLP-1R-/- mice, respectively; P = NS). After 18 weeks of high fat feeding, GLP-1R-/- mice gained similar (males) or less (females) weight than age- and sex-matched CD1 controls. No significant deterioration in glucose tolerance was observed after high fat feeding in GLP-1R-/- mice. These observations demonstrate that long term disruption of GLP-1 signaling in the central nervous system and peripheral tissues of older mice is not associated with the development of obesity or deterioration in glucose homeostasis.
Investigation on the corner effect of L-shaped tunneling field-effect transistors and their fabrication method.

In this work, electrical characteristics of L-shaped tunneling field-effect transistors (TFETs) have been studied and optimized by a commercial device simulator: Synopsys Sentaurus. Unlike our previous study performed by using Silvaco Atlas, there exists a kink phenomenon in a transfer curve which degrades the subthreshold swing (SS) and on-current (lon) of TFETs. According to simulation results, the kink results from abrupt source doping. Rounding the source junction edge with gradual doping profile is helpful to alleviate it. Based on those results, a novel fabrication flow has been proposed to suppress the kink effect induced by source corners. It is predicted that the performance of L-shaped TFETs is improved in terms of SS and Ion under the optimized process condition. Furthremore, the effect of high-k gate dielectric and narrow band gap material on device performance has been examined. Using 2-nm-thick HfO2 for gate dielectric and Si0.7Ge0. 3 for intrinsic tunneling region, gate controllability to the channel and tunneling probability have been enhanced. As a result, its threshold voltage (Vth), SS and Ion have been improved by 0.13 V, 16 mV/dec, and 3.62 microA/microm, respectively.
Sample Size Estimation for Detection of Splicing Events in Transcriptome Sequencing Data

Merging data from multiple samples is required to detect low expressed transcripts or splicing events that might be present only in a subset of samples. However, the exact number of required replicates enabling the detection of such rare events often remains a mystery but can be approached through probability theory. Here, we describe a probabilistic model, relating the number of observed events in a batch of samples with observation probabilities. Therein, samples appear as a heterogeneous collection of events, which are observed with some probability. The model is evaluated in a batch of 54 transcriptomes of human dermal fibroblast samples. The majority of putative splice-sites (alignment gap-sites) are detected in (almost) all samples or only sporadically, resulting in an U-shaped pattern for observation probabilities. The probabilistic model systematically underestimates event numbers due to a bias resulting from finite sampling. However, using an additional assumption, the probabilistic model can predict observed event numbers within a <10% deviation from the median. Single samples contain a considerable amount of uniquely observed putative splicing events (mean 7122 in alignments from TopHat alignments and 86,215 in alignments from STAR). We conclude that the probabilistic model provides an adequate description for observation of gap-sites in transcriptome data. Thus, the calculation of required sample sizes can be done by application of a simple binomial model to sporadically observed random events. Due to the large number of uniquely observed putative splice-sites and the known stochastic noise in the splicing machinery, it appears advisable to include observation of rare splicing events into analysis objectives. Therefore, it is beneficial to take scores for the validation of gap-sites into account.
Restoring with maximum likelihood and maximum entropy.

Given M sampled image values of an incoherent object, what can be deduced as the most likely object? Using a communication-theory model for the process of image formation, we find that the most likely object has a maximum entropy and is represented by a restoring formula that is positive and not band limited. The derivation is an adaptation to optics of a formulation by Jaynes for unbiased estimates of positive probability functions. The restoring formula is tested, via computer simulation, upon noisy images of objects consisting of random impulses. These are found to be well restored, with resolution often exceeding the Rayleigh limit and with a complete absence of spurious detail. The proviso is that the noise in each image input must not exceed about 40% of the signal image. The restoring method is applied to experimental data consisting of line spectra. Results are consistent with those of the computer simulations.
A GPU-accelerated two stage visual matching pipeline for image and video retrieval

We propose a two stage visual matching pipeline including a first step using VLAD signatures for filtering results, and a second step which reranks the top results using raw matching of SIFT descriptors. This enables adjusting the tradeoff between high computational cost of matching local descriptors and the insufficient accuracy of compact signatures in many application scenarios. We describe GPU accelerated extraction and matching algorithms for SIFT, which result in a speedup factor of at least 4. The VLAD filtering step reduces the number of images/frames for which the local descriptors need to be matched, thus speeding up retrieval by an additional factor of 9-10 without sacrificing mean average precision over full raw descriptor matching.
Cascading Multiway Attentions for Document-level Sentiment Classification

Document-level sentiment classification aims to assign the user reviews a sentiment polarity. Previous methods either just utilized the document content without consideration of user and product information, or did not comprehensively consider what roles the three kinds of information play in text modeling. In this paper, to reasonably use all the information, we present the idea that user, product and their combination can all influence the generation of attentions to words and sentences, when judging the sentiment of a document. With this idea, we propose a cascading multiway attention (CMA) model, where multiple ways of using user and product information are cascaded to influence the generation of attentions on the word and sentence layers. Then, sentences and documents are well modeled by multiple representation vectors, which provide rich information for sentiment classification. Experiments on IMDB and Yelp datasets demonstrate the effectiveness of our model.
Shear stress influences the pluripotency of murine embryonic stem cells in stirred suspension bioreactors

Pluripotent embryonic stem cells (ESCs) have been used increasingly in research as primary material for various tissue‐engineering applications. Pluripotency, or the ability to give rise to all cells of the body, is an important characteristic of ESCs. Traditional methods use leukaemia inhibitory factor (LIF) to maintain murine embryonic stem cell (mESC) pluripotency in static and bioreactor cultures. When LIF is removed from mESCs in static cultures, pluripotency genes are downregulated and the cultures will spontaneously differentiate. Recently we have shown the maintenance of pluripotency gene expression of mESCs in stirred suspension bioreactors during differentiation experiments in the absence of LIF. This is undesired in a differentiation experiment, where the goal is downregulation of pluripotency gene expression and upregulation of gene expression characteristic to the differentiation. Thus, the objective of this study was to examine how effectively different levels of shear stress [100 rpm (6 dyne/cm2), 60 rpm (3 dyne/cm2)] maintained and influenced pluripotency in suspension bioreactors. The pluripotency markers Oct‐4, Nanog, Sox‐2 and Rex‐1 were assessed using gene expression profiles and flow‐cytometry analysis and showed that shear stress does maintain and influence the gene expression of certain pluripotency markers. Some significant differences between the two levels of shear stress were seen and the combination of shear stress and LIF was observed to synergistically increase the expression of certain pluripotency markers. Overall, this study provides a better understanding of the environmental conditions within suspension bioreactors and how these conditions affect the pluripotency of mESCs. Copyright © 2012 John Wiley & Sons, Ltd.
Short-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort study.

OBJECTIVE To determine the short-term outcome of neuropsychiatric (NP) events upon enrollment into an international inception cohort of patients with systemic lupus erythematosus (SLE). METHODS The study was performed by the Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months of SLE diagnosis and NP events were characterized using the American College of Rheumatology case definitions. Decision rules were derived to identify NP events attributable to SLE. Physician outcome scores of NP events and patient-derived mental component summary (MCS) and physical component summary (PCS) scores of the Short Form 36 were recorded. RESULTS There were 890 patients (88.7% female) with a mean +/- SD age of 33.8 +/- 13.4 years and mean disease duration of 5.3 +/- 4.2 months. Within the enrollment window, 271 (33.5%) of 890 patients had at least 1 NP event encompassing 15 NP syndromes. NP events attributed to SLE varied from 16.5% to 33.9% using alternate attribution models and occurred in 6.0-11.5% of patients. Outcome scores for NP events attributed to SLE were significantly better than for NP events due to non-SLE causes. Higher global disease activity was associated with worse outcomes. MCS scores were lower in patients with NP events, regardless of attribution, and were also lower in patients with diffuse and central NP events. There was a significant association between physician outcome scores and patient MCS scores only for NP events attributed to SLE. CONCLUSION In SLE patients, the short-term outcome of NP events is determined by both the characteristics and attribution of the events.
The influence of grip on oxygen consumption and leg forces when using classical style roller skis

The purpose of this study was to investigate the influence of classical style roller skis' grip (static friction coefficients, μS) on cross‐country skiers' oxygen consumption and leg forces during treadmill roller skiing, when using the diagonal stride and kick double poling techniques. The study used ratcheted wheel roller skis from the open market and a uniquely designed roller ski with an adjustable camber and grip function. The results showed significantly (P ≤ 0.05) higher oxygen consumption (∼14%), heart rate (∼7%), and lower propulsive forces from the legs during submaximal exercise and a shorter time to exhaustion (∼30%) in incremental maximal tests when using roller skis with a μS similar to on‐snow skiing, while there was no difference between tests when using different pairs of roller skis with a similar, higher μS. Thus, we concluded that oxygen consumption (skiing economy), propulsive leg forces, and performance time are highly changed for the worse when using roller skis with a lower μS, such as for on‐snow skiing with grip‐waxed cross‐country skis, in comparison to ratcheted wheel roller skis with several times higher μS.
Size control of ZnO nanorod arrays grown by metalorganic chemical vapour deposition

The size control of vertically aligned ZnO nanorod arrays (NRAs) grown by catalyst-free metalorganic chemical vapour deposition is accomplished by changing the O/Zn precursor ratio. At a higher O/Zn precursor ratio, fat ZnO NRAs with excellent alignment are produced. In contrast, slim ZnO NRAs that are considerably less well aligned grow at a lower O/Zn precursor ratio. Irrespective of their different sizes and alignments, the individual ZnO nanorods are of a defect-free single-crystalline nature and of high optical quality, indicating that changing the precursor ratio is a promising way of fabricating size-controlled ZnO NRAs.
1st Class Ticket to Class I: Protein Toxins as Pathfinders for Antigen Presentation

A number of bacterial toxins have evolved diverse strategies for crossing membrane barriers in order to reach their substrates in the mammalian cytosol. Recent studies show that this property can be exploited for the delivery of fused antigens into the major histocompatibility complex class I‐restricted presentation pathway, with the goal of eliciting a specific immune response. Here we discuss the peculiarities of the trafficking pathways of a variety of toxins, and how these may allow the toxins to be used as delivery vehicles for therapeutic and diagnostic purposes.
[Surface treatment of dental implants with high-energy laser beam] .

In the present study the biological value of the laser prepared titanium implants has been investigated. Screw-type implants with different surface modifications were placed into the femurs of rabbits. Removal torque measurements and histological examinations were prepared. The examinations were divided into two groups. In the first part of the examinations the laser surface treatment was compared to other type of surface modifications. In the examination groups the implants were prepared with the following surfaces: 1. machined, 2. sandblasted, 3. low intensity laser surface, 4. high intensity laser surface, 5. titanium oxide coated surface. In the second part of the examinations laser treatment with different physical variables were observed. It has been concluded, that in both cases the high energy laser treated implants needed higher removal torque and in some cases an osteogenic activity was observed around them in the medullary space as well. The authors think the advantage of laser surface treatment lies in special micromorphology and the increased cleanliness of the surface.