Miracle-dz/UniFAR-FTUs huggingface dataset:
Cryptic and partial deletions of PRDM16 and RUNX1 without t(1;21)(p36;q22) and/or RUNX1–PRDM16 fusion in a case of progressive chronic myeloid leukemia: A complex chromosomal rearrangement of underestimated frequency in disease progression?

Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the presence in leukemic stem cells of the Philadelphia chromosome (Ph) and the formation of the BCR‐ABL1 fusion. Untreated, the disease progresses to accelerate phase and blast crisis in which hematopoietic differentiation has become arrested. CML progression is frequently associated with cytogenetic evidence of clonal evolution, defined as additional chromosomal aberrations. We here report a CML resistant to tyrosine kinase inhibitors that rapidly progressed to blastic phase. At this time, array CGH performed on CD34+ cells revealed cryptic partial deletions of both PRDM16 and RUNX1 and duplication of the der(21) chromosome. These genomic rearrangements were confirmed by FISH with probes targeting the deletion on chromosome 21 (24 kb), and with BAC probes flanking the deletion on 1p36 (220 kb). However, no cryptic t(1;21)(p36;q22) and/or RUNX1‐PRDM16 were detected, suggesting that these deletions are the residual hallmarks of a more complex mechanism of chromosomal rearrangement, as indicated by the additional inversion of the region bounded by 1p36.32 and 1p36.12 breaks. At the molecular level, these abnormalities lead to the overexpression of the PR‐domain negative oncogenic isoform of PRDM16, associated with two deleted copies within the runt domain of C‐teminal aberrant RUNX1. These events are not detectable by conventional cytogenetic and molecular strategies, and may be of underestimated frequency in disease progression. © 2008 Wiley‐Liss, Inc.
Quality of Experience for cognitive multiple antenna systems

Multiple Input Multiple Output (MIMO) adds a new dimension, the spatial one, to be optimized in Cognitive Radio (CR) by delivering service simultaneously to more than one user. In this paper, statistical optimization techniques are carried out to assess the Quality of Experience (QoE) performance where each type of users has different demands. The Multiuser scenario is considered where the transmitter can accomplish an Opportunistic Scheduling approach. Closed form expressions are derived for different scenarios and obtained for the QoE indicators in the system regarding the minimum guaranteed throughput and maximum allowed scheduling delay. The primary users and secondary users performance within such scenarios are mathematically formulated and compared their results to simulations.
Academic and social adaptation through a college success course: A case study of second semester students at a suburban community college in northern New Jersey

vi List of Tables . xiv Chapter 1: Introduction . 1 Purpose . 4 Significance.5 Assumptions . 7 Limitations . 9 Conceptual Framework . 10 Research Questions . 12 Study Definitions . 13 Summary . 16 Chapter 2: Literature Review . 19 College Readiness and Higher Education . 20 Community Colleges . 22 Community College Student Demographic . 24 First-Generation Students . 25 Other Underserved Student Populations . 25 The First-Year Experience . 27 First-Year High Impact Practices . 29 College Success Courses/First-Year Seminars . 31 History.31 Course Structure.33
Antibodies to Brucella spp. in Pacific Bottlenose Dolphins from the Solomon Islands

Brucella spp. have been recently isolated from a variety of marine mammals. Serum samples from 58 Pacific bottlenose dolphins (Tursipa aduncus) from the Solomon Islands were tested for antibodies to Brucella spp. by the tube agglutination test (TAT), enzymed-linked immunosorbent assay (ELISA), and immunoblotting. Anti-Brucella spp. antibodies were detected by TAT and ELISA in 31 and 40 of 58 samples, respectively. These results suggest that Pacific bottlenose dolphins from the Solomon Islands are infected with Brucella spp. or a Brucella-like organism.
Borderline Personality Disorder, Stigma, and Treatment Implications

&NA; Borderline personality disorder (BPD) is often viewed in negative terms by mental health practitioners and the public. The disorder may have a stigma associated with it that goes beyond those associated with other mental illnesses. The stigma associated with BPD may affect how practitioners tolerate the actions, thoughts, and emotional reactions of these individuals. It may also lead to minimizing symptoms and overlooking strengths. In society, people tend to distance themselves from stigmatized populations, and there is evidence that some clinicians may emotionally distance themselves from individuals with BPD. This distancing may be especially problematic in treating patients with BPD; in addition to being unusually sensitive to rejection and abandonment, they may react negatively (e.g., by harming themselves or withdrawing from treatment) if they perceive such distancing and rejection. Clinicians' reactivity may be self‐protective in response to actual behavior associated with the pathology. As a consequence, however, the very behaviors that make it difficult to work with these individuals contribute to the stigma of BPD. In a dialectical relationship, that stigma can influence the clinician's reactivity, thereby exacerbating those same negative behaviors. The result is a self‐fulfilling prophecy and a cycle of stigmatization to which both patient and therapist contribute. The extent to which therapist distancing is influenced by stigma is an important question that highlights the possibility that the stigma associated with BPD can have an independent contribution to poor outcome with this population. A final issue concerns the available means for identifying and limiting the impact of stigmatization on the treatment of individuals with BPD.
Clinical highlights from the National Cancer Data Base: 1995

The National Cancer Data Base, a joint project of the American Cancer Society and the American College of Surgeons Commission on Cancer, provides a mechanism for periodic assessment of hospital-based cancer patient care. From the National Cancer Data Base's annual summary, health care professionals can evaluate trends in patient care to make more efficient treatment decisions. This article provides a first look at highlights of the 1995 annual summary.
Step modulated multilevel inverter incorporated upon ANFIS based intelligent PV MPPT

Building Integrated solar cell has now becoming the rising Trend in the area of industrial drives and energy conversion. This paper focuses on the interfacing of MPPT based Photovoltaic cell with Cascade Multilevel Inverter. Integrated PV panel has performance losses due to quick variation in solar light intensity and temperature of the solar panel. This constraint on PV side is managed by an effective Adaptive neuro fuzzy [ANFIS] based intelligent MPPT control algorithm. The system also incorporates a power conditioning unit (Inverter). The switching angle calculation for the inverter is determined by a novel algorithm. The innovation of paper lies on the interfacing of ANFIS based MPPT with a novel switching angle algorithm based MultiLevel Inverter.
Design and analysis of new substrate integrated waveguide resonance antennas

In this paper new antennas using an open-ended substrate integrated waveguide (SIW) resonator are presented. The open-ended SIW resonator is analyzed using two different approaches. In the first approach we use the waveguide theory and in the second approach we use the transmission line (TL) based metamaterials theory. Using the SIW resonator, two antennas are designed and simulated. The first one operates at the first order resonance mode of the resonator. The operating frequency, bandwidth, maximum gain and radiation efficiency of this antenna are 8.33 GHz, 1.9%, 7.3 dBi and 94%, respectively. The second antenna which has a half mode substrate integrated waveguide (HMSIW) structure operates at the zeroth order resonance mode of the resonator. Its operating frequency, bandwidth, maximum gain and radiation efficiency are 5.72 GHz, 1.2%, 4.2 dBi and 95%, respectively. The presented antennas have advantages of low profile, easy fabrication, easy integration with other circuits and high efficiency.
Dietary glycine and blood pressure: the International Study on Macro/Micronutrients and Blood Pressure.

BACKGROUND Available data have indicated independent direct relations of dietary animal protein and meat to the blood pressure (BP) of individuals. OBJECTIVE In this study, we aimed to assess whether BP is associated with the intake of dietary amino acids higher relatively in animal than in vegetable protein (alanine, arginine, aspartic acid, glycine, histidine, lysine, methionine, and threonine). DESIGN The study was a cross-sectional epidemiologic study that involved 4680 persons aged 40-59 y from 17 random population samples in the People's Republic of China, Japan, the United Kingdom, and the United States. BP was measured 8 times at 4 visits; dietary data (83 nutrients and 18 amino acids) were from four 24-h dietary recalls and two 24-h urine collections. RESULTS Dietary glycine and alanine (the percentage of total protein intake) were considered singly related directly to BP; with these 2 amino acids together in regression models (from model 1, which was controlled for age, sex, and sample, to model 5, which was controlled for 16 possible confounders), glycine, but not alanine, was significantly related to BP. Estimated average BP differences associated with a 2-SD higher glycine intake (0.71 g/24 h) were 2.0-3.0-mm Hg systolic BP (z = 2.97-4.32) stronger in Western than in East Asian participants. In Westerners, meat was the main dietary source of glycine but not in East Asians (Chinese: grains/flour and rice/noodles; Japanese: fish/shellfish and rice/noodles). CONCLUSION Dietary glycine may have an independent adverse effect on BP, which possibly contributes to direct relations of animal protein and meat to BP.
A novel 3D crossbar-based chip multiprocessor architecture

Moore's law still offers more transistors to fit per die unit area and this leads to the expectation of having thousands of cores fit on a single chip soon. Thus, Network-on-Chip proved to be a successful approach to accommodate this increasing number of cores on chip. However, the previously proposed 2D architectures still lack the scalability to more than few tens of cores where the inefficiencies of those architectures come in the form of long interconnect delays leading to performance degradation and high power consumption due to long wires. Fortunately, the rapid advances in 3D die-stacking technology as a promising trend for the state of the art high-performance processor designs raised the possibilities of having new approaches towards a scalable interconnection network. Thus, in this paper, we propose a novel 3D crossbar-based architecture that separates cores from cache modules in different 3D stacked dies.We introduce area model of the adopted crossbar and analyze the scalability of the proposed architecture up to 1024 communicating entities; cores and L2 cache banks.
Ketamine Attenuates the Interleukin-6 Response After Cardiopulmonary Bypass

Cardiopulmonary bypass (CPB) has been proposed as a model for studying the inflammatory cascade associated with the systemic inflammatory response syndrome.Serum interleukin-6 (IL-6) concentration seems to be a good indicator of activation of the inflammatory cascade and predictor of subsequent organ dysfunction and death. Prolonged increases of circulating IL-6 are associated with morbidity and mortality after cardiac operations. In the present study, we compared the effects of adding ketamine 0.25 mg/kg to general anesthesia on serum IL-6 levels during and after elective coronary artery bypass grafting (CABG). Thirty-one patients undergoing elective CABG were randomized to one of two groups and prospectively studied in a double-blind manner. The patients received either ketamine 0.25 mg/kg or a similar volume of isotonic sodium chloride solution in addition to large-dose fentanyl anesthesia. Blood samples for analysis of serum IL-6 levels were drawn before the operation; after CPB; 4, 24, and 48 h after surgery; and daily for 6 days beginning the third day postoperatively. Ketamine suppressed the serum IL-6 response immediately after CPB and 4, 24, and 48 h postoperatively (P < 0.05). During the first 7 days after surgery, the serum IL-6 levels in the ketamine group were significantly lower than those in the control group (P < 0.05). On Day 8 after surgery, IL-6 levels were no different from baseline values in both groups. A single dose of ketamine 0.25 mg/kg administered before CPB suppresses the increase of serum IL-6 during and after CABG. Implications: In this randomized, double-blind, prospective study of patients during and after coronary artery bypass surgery, we examined whether small-dose ketamine added to general anesthesia before cardiopulmonary bypass suppresses the increase of the serum interleukin-6 (IL-6) concentration. Serum IL-6 levels correlate with the patient's clinical course during and after coronary artery bypass. Ketamine suppresses the increase of serum IL-6 during and after coronary artery bypass surgery. (Anesth Analg 1998;87:266-71)
Blood use during extracorporeal membrane oxygenation

An analysis of the transfusion records of 91 neonatal patients subjected to extracorporeal membrane oxygenation (ECMO) is reported. Mean daily blood usage was 250 mL of red cells (RBCs), 80 mL of fresh‐frozen plasma, and 2 units of platelets. Average time on ECMO was 4.6 days. Group O or ABO type‐specific RBCs and group AB or ABO type‐specific plasma products and platelets were transfused. RBCs were not washed, and neither RBCs nor other components were tested for anticytomegalovirus (CMV) or irradiated. No cases of posttransfusion CMV infection or graft‐versus‐host disease were observed. Hemolysis in eight patients was traced to occlusions in the ECMO circuit. All but three patients survived ECMO. Contrary to a previous report, an active ECMO program for neonatal patients imposes a minimal burden on the hospital transfusion service.
Regulation of ubiG gene expression in Escherichia coli

To study the regulation of the expression in Escherichia coli of the ubiG gene, which codes for the last enzyme in the pathway of ubiquinone biosynthesis, a fusion between the ubiG and lacZ genes was constructed in vitro. The results showed that (i) the expression of the ubiG gene was higher under aerobic conditions than under anaerobic growth conditions, (ii) the presence of glucose in the culture medium decreased the transcription of the ubiG gene, and (iii) cya and crp mutants exhibited lower levels of ubiG gene expression than the wild-type strain. The addition of cyclic AMP increased the expression of the ubiG gene in both cya and wild-type strains but not in a crp mutant. This fact suggests that the cyclic AMP receptor protein-cyclic AMP complex positively modulates ubiG gene transcription. It was also determined that the transcription of the ubiG gene was in the counterclockwise direction on the E. coli map.
Empirical Analysis of Financial Performance of Listed Company in Retail Based on Factor Analysis Method

This paper use factor analysis method to compare the financial performance of listed retail companies horizontally. We can get the level of the development of the company in the industry. Because the data of every year are available, every year factor analysis can be carried out and obtained a comprehensive score, which is a dynamic and changing analysis process. It provides us the direction for the improvement of enterprise’s financial performance.
E-Learning Readiness of Jordanian Universities

E-learning became very important to the universities success and it considered as one of the key success factors, in which it’s enhanced the competitive advantage and help in competing strongly in the market. Using Information technologies and sharing tools will add value to the educational process and by using these tools; the universities will have the power of innovation and creativity. E-learning helps in developing, managing and maintaining the students knowledge, on the other hand, it enhances the performance and learning capacity to remain innovation and competitive. This paper is measuring the readiness of the Jordanian universities for e-learning. It presents the main findings of a survey conducted to evaluate the e-learning readiness. The survey helped in analyzing three levels used for the measurement: ICT infrastructure, universities lecturers and students’ readiness, and the maturity of the external environment. Keywords : E-learning, IT infrastructure, Demand, External Environment, and HR readiness.
Life post-study abroad for the Japanese language learner: Social networks, interaction and language usage

Over the past two decades, there has been a steady increase in studies concerning language learners’ out-of-class interaction and social network development in study abroad contexts (e.g. Kato & Tanibe, 1997; Tanaka, 2007; Ayano, 2006; Isabelli-Garcia, 2006; Pearson-Evans, 2006; Zappa, 2007; Meier & Daniels, 2011; Dewey, Bown & Eggett, 2012; Trentman, 2013; research in this volume). However, to date, there has been very little research into the ongoing impact of study abroad on learners’ target language (TL) speaking networks once they return to their home countries. Do they maintain these newly developed networks and/or demonstrate an enhanced ability to expand TL networks once removed from the study abroad environment? Moreover, do these networks continue to provide opportunities for TL usage, or do frequent contact with TL speakers, and opportunities for language use and learning, become but a lingering memory of the study abroad experience? These questions have become the focus of the present research, which, based within a larger doctoral project, investigates the impact of various university-level study abroad programmes on Japanese language learners’ social networks with Japanese speakers after they returned to Australia. In this chapter, I provide a brief review of the literature concerning the benefits of study abroad, and then narrow the focus to studies regarding social interaction, network maintenance and/or development, and language use in post-study abroad contexts. I then introduce the methodology employed in this study, followed by a discussion of findings and directions for future research.
Exploring the co-benefits (and costs) of home gardening for biodiversity conservation

ABSTRACT Despite growing evidence pointing to the multiple benefits of home gardening, few studies have considered the health and well-being benefits perceived by gardeners who are principally motivated by biodiversity conservation (i.e. home gardening for biodiversity conservation). This study explores the environmental, social and economic co-benefits (and costs) of home gardening for biodiversity conservation in the City of Winnipeg, Canada. A total of 42 semi-structured interviews (30–60 min each) were conducted with 50 home gardeners who were formally certified or locally recognised for undertaking multiple gardening activities that promote biodiversity conservation. Thematic analysis revealed that study participants self-reported a range of environmental, psychological, physiological and social outcomes associated with their home gardening experiences. Despite home gardening often being a solitary activity, most gardeners valued the multiple forms of social interaction that occurred during important social events in their garden, or when connecting with passers-by. Home gardeners also cited benefits related to connection to nature and place attachment; attention restoration; reduced stress and anxiety; improved mood; satisfaction and pride; increased self-esteem and courage to do things differently in life; and, important education or learning opportunities. However, conflicts relating to the nexus between biodiversity and perceived tidiness of gardens emerged, which raise important ethical and social justice issues for sustainability planning. We compare key insights to the benefits (and costs) of community gardening and make some recommendations for future research, including how to engage more disadvantaged groups in gardening for conservation.
Medicare physician reimbursement: past, present, and future.

Recent proposals in the United States to cut Medicare physician-reimbursement rates for certain orthopaedic procedures, particularly in the field of hip and knee arthroplasty, have heightened the general orthopaedic community's interest in Medicare physician-reimbursement policy. Familiarizing oneself with Medicare physician-reimbursement policies in particular is important as most private and public insurers base their payments on Medicare fee schedules and regulations. The 2004 American Academy of Orthopaedic Surgeons (AAOS) Physician Census revealed that >90% of orthopaedists in private practice identified insurance or Medicare and Medicaid reimbursement levels and increasing practice expenses as major concerns1. Medicare and Medicaid accounted for an average of 33% of an orthopaedist's practice in 2006, having risen steadily from 26% in 19882. This article is a primer on the history of the Medicare Physician Fee Schedule, its current status, and issues that are currently at the forefront of Medicare health policy agendas in the United States. We conclude with a discussion of the proposed changes to the sustained growth rate formula and the design and implementation of pay-for-performance programs. The AAOS has led the charge in representing orthopaedic interests in Washington, DC, and in keeping its membership updated on issues through bulletins and legislative updates. However, for physicians and researchers interested in understanding the issues surrounding Medicare, the task of sifting through and integrating the myriad of academic, governmental, and organizational resources available is daunting. We aim to organize these sources into an accessible, unified format. We also present the orthopaedic surgeon with opportunities to become involved in shaping future policy at a range of commitment levels. In 1965, President Lyndon B. Johnson signed the Title XVIII Amendment to the 1933 Social Security Act, creating Medicare as the first major federal health insurance entitlement program. The program's original goal was to reduce the …
Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells.

We examined the expression and function of gap junctions in two rat osteoblastic cell lines, ROS 17/2.8 and UMR 106‐01. The pattern of expression of gap junction proteins in these two cell lines was distinct: ROS cells expressed only connexin43 on their cell surface, while UMR expressed predominantly connexin45. Immunoprecipitation and RNA blot analysis confirmed the relative quantitation of these connexins. Microinjected ROS cells passed Lucifer yellow to many neighboring cells, but UMR cells were poorly coupled by this criterion. Nevertheless, both UMR and ROS cells were electrically coupled, as characterized by the double whole cell patch‐clamp technique. These studies suggested that Cx43 in ROS cells mediated cell‐cell coupling for both small ions and larger molecules, but Cx45 in UMR cells allowed passage only of small ions. To demonstrate that the expression of different connexins alone accounted for the lack of dye coupling in UMR cells, we assessed dye coupling in UMR cells transfected with either Cx43 or Cx45. The UMR/Cx43 transfectants were highly dye coupled compared with the untransfected UMR cells, but the UMR/Cx45 transfectants demonstrated no increase in dye transfer. These data demonstrate that different gap junction proteins create channels with different molecular permeabilities; they suggest that different connexins permit different types of signalling between cells.