Miracle-dz/UniFAR-FTUs huggingface dataset:
A transcoding framework with error-resilient video/depth rate allocation for mobile 3D video streaming

With the development of wireless multimedia communication, mobile 3D video will be gradually popular as it can make people enjoy the natural 3D experience anywhere and anytime. In the current stage, mobile 3D video is usually distributed over the error-prone and heterogeneous network which consists of wire-line and wireless channels. In such applications, the transcoding plays an important role to provide the adaptive and error-resilient bit-stream to the wireless channel. To guarantee the high quality mobile 3D video streaming, this paper proposes a transcoding framework with error-resilient video/depth rate allocation, which utilizes the multi-pass re-encodings to build a rate allocation table (Rate-QP-PLR (packet loss rate) table). Through looking up the table, the proposed framework can select the optimal transcoding quantization parameters (QPs) of video and depth to obtain the error-resilient 3D video transmission and therefore it can make the encoded stream adapt to the transition from wire-line to wireless network. Experimental results show that the proposed 3D video transcoding framework can provide the superior rate-distortion performance for the mobile 3D video streaming.
Asymmetries In The Exchange Rate Pass-Through Into Romanian Price Indices

The article examines the asymmetries of the exchange rate pass-through (ERPT) into import, producer and consumer price indices for the Romanian economy. Using three econometric methods naturally equipped to capture various types of asymmetries (MS-VAR, TAR and SETAR), important asymmetries with respect to sign and size of the exchange rate, size of inflation and time period have been detected.
Examination of long-term bond iShare option selling strategies

This article examines volatility trades in Lehman Brothers 20+ Year US Treasury Index iShare (TLT) options from July 2003 through May 2007. Unconditionally selling front contract strangles and straddles and holding for one month is highly profitable after transactions costs. Short‐term option selling strategies are enhanced when implied volatility is high relative to time series volatility forecasts. Risk management strategies such as stop loss orders detract from profitability, while take profit orders have only modest favorable effects on profitability. Overall, the results demonstrate that TLT option selling strategies offered attractive risk‐return tradeoffs over the sample period. © 2009 Wiley Periodicals, Inc. Jrl Fut Mark 30:465–489, 2010
Omega-3 fatty acids attenuate constitutive and insulin-induced CD36 expression through a suppression of PPARα/γ activity in microvascular endothelial cells

Summary Microvascular dysfunction occurs in insulin resistance and/or hyperinsulinaemia. Enhanced uptake of free fatty acids (FFA) and oxidised low-density lipoproteins (oxLDL) may lead to oxidative stress and microvascular dysfunction interacting with CD36, a PPARα/γ-regulated scavenger receptor and long-chain FFA transporter. We investigated CD36 expression and CD36-mediated oxLDL uptake before and after insulin treatment in human dermal microvascular endothelial cells (HMVECs), ± different types of fatty acids (FA), including palmitic, oleic, linoleic, arachidonic, eicosapentaenoic (EPA), and docosahexaenoic (DHA) acids. Insulin (10−8 and 10−7 M) time-dependently increased DiI-oxLDL uptake and CD36 surface expression (by 30 ± 13%, p<0.05 vs. untreated control after 24 hours incubation), as assessed by ELISA and flow cytometry, an effect that was potentiated by the PI3-kinase inhibitor wortmannin and reverted by the ERK1/2 inhibitor PD98059 and the PPARα/γ antagonist GW9662. A ≥24 hour exposure to 50 μM DHA or EPA, but not other FA, blunted both the constitutive (by 23 ± 3% and 29 ± 2%, respectively, p<0.05 for both) and insulin-induced CD36 expressions (by 45 ± 27 % and 12 ± 3 %, respectively, p<0.05 for both), along with insulin-induced uptake of DiI-oxLDL and the downregulation of phosphorylated endothelial nitric oxide synthase (P-eNOS). At gel shift assays, DHA reverted insulin-induced basal and oxLDL-stimulated transactivation of PPRE and DNA binding of PPARα/γ and NF-κB. In conclusion, omega-3 fatty acids blunt the increased CD36 expression and activity promoted by high concentrations of insulin. Such mechanisms may be the basis for the use of omega-3 fatty acids in diabetic microvasculopathy.
Clinical application of retroviral gene transfer in oncology: results of a French study with tumor-infiltrating lymphocytes transduced with the gene of resistance to neomycin.

PURPOSE Adoptive immunotherapy with tumor-infiltrating lymphocytes (TIL) and interleukin-2 (IL-2) has been reported to mediate tumor regression in some human cancers. To define better the biologic characteristics of TIL, especially survival and distribution in vivo, we performed a gene-marker study in patients with advanced malignancies. PATIENTS AND METHODS We treated five patients with metastatic melanoma or renal cell carcinoma with adoptive immunotherapy. TIL were genetically modified, before their infusion, using a recombinant retroviral vector that contained the marker gene coding for resistance to neomycin (NeoR). RESULTS All of the patients tolerated the treatment well and none of the theoretic safety hazards due to the retroviral gene transduction was observed. The presence of the NeoR gene in TIL was detected by Southern blot analysis, with an efficiency of transduction that ranged from 1% to 26%. With polymerase chain reaction (PCR) analysis, we demonstrated that gene-modified TIL can survive for several months after reinjection, since positive blood samples were observed up to day 260 following reinjection. Eight malignant biopsy specimens were obtained from three patients after cell infusion. TIL were detected in only four of these eight tumor deposits on days 7 and 260. CONCLUSION These results confirm the feasibility and safety of using in vitro retroviral gene transduction in human lymphocytes to analyze their in vivo distribution for further therapeutic applications. However, a selective and prolonged retention of TIL at the tumor site was not found in this study.
Biosynthetic Origin of the Antibiotic Pseudopyronines A and B in Pseudomonas putida BW11M1

Within the framework of our effort to discover new antibiotics from pseudomonads, pseudopyronines A and B were isolated from the plant‐derived Pseudomonas putida BW11M1. Pseudopyronines are 3,6‐dialkyl‐4‐hydroxy‐2‐pyrones and displayed high in vitro activities against several human pathogens, and in our hands also towards the plant pathogen Pseudomonas savastanoi. Here, the biosynthesis of pseudopyronine B was studied by a combination of feeding experiments with isotopically labeled precursors, genomic sequence analysis, and gene deletion experiments. The studies resulted in the deduction of all acetate units and revealed that the biosynthesis of these α‐pyrones occurs with a single PpyS‐homologous ketosynthase. It fuses, with some substrate flexibility, a 3‐oxo‐fatty acid and a further unbranched saturated fatty acid, both of medium chain‐length and provided by primary metabolism.
Clinical Experience of Colistin-Glycopeptide Combination in Critically Ill Patients Infected with Gram-Negative Bacteria

ABSTRACT A colistin-glycopeptide combination (CGC) has been shown in vitro to be synergistic against multidrug-resistant Gram-negative bacteria (MDR GNB), especially Acinetobacter baumannii, and to prevent further resistance. However, clinical data are lacking. We carried out a retrospective multicenter study of patients hospitalized in intensive care units (ICUs) who received colistin for GNB infection over a 1-year period, to assess the rates of nephrotoxicity and 30-day mortality after treatment onset among patients treated with and without CGC for ≥48 h. Of the 184 patients treated with colistin, GNB infection was documented for 166. The main causative agents were MDR A. baumannii (59.6%), MDR Pseudomonas aeruginosa (18.7%), and carbapenem-resistant Klebsiella pneumoniae (14.5%); in 16.9% of patients, a Gram-positive bacterium (GPB) coinfection was documented. Overall, 68 patients (40.9%) received CGC. Comparison of patients treated with and without CGC showed significant differences for respiratory failure (39.7% versus 58.2%), ventilator-associated pneumonia (54.4% versus 71.4%), MDR A. baumannii infection (70.6% versus 52%), and GPB coinfection (41.2% versus 0%); there were no differences for nephrotoxicity (11.8% versus 13.3%) and 30-day mortality (33.8% versus 29.6%). Cox analysis performed on patients who survived for ≥5 days after treatment onset showed that the Charlson index (hazard ratio [HR], 1.26; 95% confidence interval [CI], 1.01 to 1.44; P = 0.001) and MDR A. baumannii infection (HR, 2.51; 95% CI, 1.23 to 5.12; P = 0.01) were independent predictors of 30-day mortality, whereas receiving CGC for ≥5 days was a protective factor (HR, 0.42; 95% CI, 0.19 to 0.93; P = 0.03). We found that CGC was not associated with higher nephrotoxicity and was a protective factor for mortality if administered for ≥5 days.
Diversification of the Histone Acetyltransferase GCN5 through Alternative Splicing in Brachypodium distachyon

The epigenetic modulatory SAGA complex is involved in various developmental and stress responsive pathways in plants. Alternative transcripts of the SAGA complex's enzymatic subunit GCN5 have been identified in Brachypodium distachyon. These splice variants differ based on the presence and integrity of their conserved domain sequences: the histone acetyltransferase domain, responsible for catalytic activity, and the bromodomain, involved in acetyl-lysine binding and genomic loci targeting. GCN5 is the wild-type transcript, while alternative splice sites result in the following transcriptional variants: L-GCN5, which is missing the bromodomain and S-GCN5, which lacks the bromodomain as well as certain motifs of the histone acetyltransferase domain. Absolute mRNA quantification revealed that, across eight B. distachyon accessions, GCN5 was the dominant transcript isoform, accounting for up to 90% of the entire transcript pool, followed by L-GCN5 and S-GCN5. A cycloheximide treatment further revealed that the S-GCN5 splice variant was degraded through the nonsense-mediated decay pathway. All alternative BdGCN5 transcripts displayed similar transcript profiles, being induced during early exposure to heat and displaying higher levels of accumulation in the crown, compared to aerial tissues. All predicted protein isoforms localize to the nucleus, which lends weight to their purported epigenetic functions. S-GCN5 was incapable of forming an in vivo protein interaction with ADA2, the transcriptional adaptor that links the histone acetyltransferase subunit to the SAGA complex, while both GCN5 and L-GCN5 interacted with ADA2, which suggests that a complete histone acetyltransferase domain is required for BdGCN5-BdADA2 interaction in vivo. Thus, there has been a diversification in BdGCN5 through alternative splicing that has resulted in differences in conserved domain composition, transcript fate and in vivo protein interaction partners. Furthermore, our results suggest that B. distachyon may harbor compositionally distinct SAGA-like complexes that differ based on their histone acetyltransferase subunit.
Treatment of bile acid amidation defects with glycocholic acid

Bile acid amidation defects were predicted to present with fat/fat soluble vitamin malabsorption with minimal cholestasis. We identified and treated five patients (one male, four females) from four families with defective bile acid amidation due to a genetically confirmed deficiency in bile acid CoA:amino acid N‐acyl transferase (BAAT) with the conjugated bile acid, glycocholic acid (GCA). Fast atom bombardment‐mass spectrometry analysis of urine and bile at baseline revealed predominantly unconjugated cholic acid and absence of the usual glycine and taurine conjugated primary bile acids. Treatment with 15 mg/kg GCA resulted in total duodenal bile acid concentrations of 23.3 ± 19.1 mmol/L (mean ± SD) and 63.5 ± 4.0% of the bile acids were secreted in bile in the conjugated form, of which GCA represented 59.6 ± 9.3% of the total biliary bile acids. Unconjugated cholic acid continued to be present in high concentrations in bile because of partial intestinal deconjugation of orally administered GCA. Serum total bile acid concentrations did not significantly differ between pretreatment and posttreatment samples and serum contained predominantly unconjugated cholic acid. These findings confirmed efficient intestinal absorption, hepatic extraction, and biliary secretion of the administered GCA. Oral tolerance tests for vitamin D2 (1,000 IU vitamin D2/kg) and tocopherol (100 IU/kg tocopherol acetate) demonstrated improvement in fat‐soluble vitamin absorption after GCA treatment. Growth improved in 3/3 growth‐delayed prepubertal patients. Conclusion: Oral glycocholic acid therapy is safe and effective in improving growth and fat‐soluble vitamin absorption in children and adolescents with inborn errors of bile acid metabolism due to amidation defects. (Hepatology 2015;61:268–274)
Bright X-ray Flares in Gamma-Ray Burst Afterglows

Gamma-ray burst (GRB) afterglows have provided important clues to the nature of these massive explosive events, providing direct information on the nearby environment and indirect information on the central engine that powers the burst. We report the discovery of two bright x-ray flares in GRB afterglows, including a giant flare comparable in total energy to the burst itself, each peaking minutes after the burst. These strong, rapid x-ray flares imply that the central engines of the bursts have long periods of activity, with strong internal shocks continuing for hundreds of seconds after the gamma-ray emission has ended.
Modeliranje socijalno-gospodarskih aspekata uporabe energije biomase

For complete evaluation of biomass as a renewable energy source, different socio-economic impacts should be taken into account. Using biomass enables employment, increase of local and regional economic activities and additional income. The paper describes the methodology that includes procedure for analysis of investigated area (data types and data collection methods), methods for data processing and analysis, as well as basic principles of bioenergy sector modelling that includes all key socio-economic impacts.
Entrepreneurship Reduces Income Inequality

In the present note an effort will be made to point out that entrepreneurship reduces income inequality. Entrepreneurship reward is a measurable economic variable and can be therefore related to gini coefficient, which is an indicator of income inequality. Panel data refer to the period (1995–2004) covering most Western European countries and the estimated panel regression will be feasible using the software package EVIEWS.
Fast mixed-signal simulation using SystemC

Today's simulation tools can not keep up with novel design methodologies at system level such as TLM. We propose to automatically precompute numerical models from analog netlists and interface a simulation kernel via SystemC to the digital domain. Our simulation system has performed orders of magnitude faster compared to traditional analog circuit simulators interfaced to SystemC while keeping full accuracy.
Flexible Modelling of Duration of Unemployment Using Functional Hazard Models and Penalized Splines: A Case Study Comparing Germany and the UK

The intention of this paper is to demonstrate the flexibility and capacity of penalized spline smoothing as estimation routine for modelling duration time data. We investigate the unemployment behaviour in Germany and the UK between 1995 and 2005 based on data from national panel studies. Functional duration time models are used to investigate the dynamics of covariate effects. The focus of our analysis is on contrasting the two economies. The statistical model being employed is built upon the hazard function, where we allow all covariate effects to vary smoothly with time. As result of the analyses, we demonstrate that the most striking difference between the countries is that elderly unemployed in Germany have decreasing chances for reemployment compared to the UK.
Tensor-Train Recurrent Neural Networks for Video Classification

The Recurrent Neural Networks and their variants have shown promising performances in sequence modeling tasks such as Natural Language Processing. These models, however, turn out to be impractical and difficult to train when exposed to very high-dimensional inputs due to the large input-to-hidden weight matrix. This may have prevented RNNs' large-scale application in tasks that involve very high input dimensions such as video modeling; current approaches reduce the input dimensions using various feature extractors. To address this challenge, we propose a new, more general and efficient approach by factorizing the input-to-hidden weight matrix using Tensor-Train decomposition which is trained simultaneously with the weights themselves. We test our model on classification tasks using multiple real-world video datasets and achieve competitive performances with state-of-the-art models, even though our model architecture is orders of magnitude less complex. We believe that the proposed approach provides a novel and fundamental building block for modeling high-dimensional sequential data with RNN architectures and opens up many possibilities to transfer the expressive and advanced architectures from other domains such as NLP to modeling high-dimensional sequential data.
Pertussis Toxin Utilizes Proximal Components of the T-Cell Receptor Complex To Initiate Signal Transduction Events in T Cells

ABSTRACT Pertussis toxin (PTx) is an AB5 toxin produced by the human pathogen Bordetella pertussis. Previous work demonstrates that the five binding (B) subunits of PTx can have profound effects on T lymphocytes independent of the enzymatic activity of the A subunit. Stimulation of T cells with holotoxin (PTx) or the B subunit alone (PTxB) rapidly induces signaling events resulting in inositol phosphate accumulation, Ca2+ mobilization, interleukin-2 (IL-2) production, and mitogenic cell growth. Although previous reports suggest the presence of PTx signaling receptors expressed on T cells, to date, the receptor(s) and membrane proximal signaling events utilized by PTx remain unknown. Here we genetically and biochemically define the membrane proximal components utilized by PTx to initiate signal transduction in T cells. Using mutants of the Jurkat T-cell line deficient for key components of the T-cell receptor (TCR) pathway, we have compared stimulation with PTx to that of anti-CD3 monoclonal antibody (MAb), which directly interacts with and activates the TCR complex. Our genetic data in combination with biochemical analysis show that PTx (via the B subunit) activates TCR signaling similar to that of anti-CD3 MAb, including activation of key signaling intermediates such as Lck, ZAP-70, and phospholipase C-γ1. Moreover, the data indicate that costimulatory activity, as provided by CD28 ligation, is required for PTx to fully stimulate downstream indicators of T-cell activation such as IL-2 gene expression. By illuminating the signaling pathways that PTx activates in T cells, we provide a mechanistic understanding for how these signals deregulate immune system functions during B. pertussis infection.
Online portrayals of volunteer tourism in Nepal: Exploring the communicated disparities between promotional and user-generated content

Purpose – This study aims to contribute perspective into how user-generated content (UGC) can be found to reinforce, or challenge, the commercial promotion of volunteer tourism in Nepal. Volunteer tourism is an expanding alternative niche market spanning the globe. More understanding is needed to identify potential conflicts that may arise in relation to information communicated via official promotional materials from volunteer tourism organisation websites and from UGC on sites such as TripAdvisor. Design/methodology/approach – A qualitative content analysis of websites and online UGC gathered from identified promotional websites and TripAdvisor used to inform and persuade tourists was analysed. Findings – Three themes emerged from the analysis of promotional websites: perspective outcomes of volunteerism on locals and VolunTourists, requirements of participating volunteers and the ability of volunteer organisations to effectively meet expectations. The TripAdvisor forum content is broken down into two m.
Innovation, Growth, and Labor Market Policy

The purpose of the paper is to study the effects of labor market policies on the equilibrium rate of growth in the Grossman-Helpman model. For that purpose, the version of the their model developed by Klette and Kortum to explain the distribution of firm size is extended to allow for both capital and labor inputs in the production process. The effects of minimum wages, payroll taxes, hiring subsidies, and employment protections are derived. For the sake of comparison, both the case of a competitive labor market and another in which rents are shared as a consequence of search friction are considered. Reference: Klette, T.J., and S. Kortum (2002) “Innovating Firms and Aggregate Innovation,” NBER Working Paper 8819.
Inhibiting aberrant Stat3 function with molecular therapeutics: a progress report

Aberrantly activated signal transducer and activator of transcription 3 (Stat3) protein plays a master regulatory role in the progression and survival of human cancers through the upregulation of target protooncogenes. Numerous human cancers, including breast, ovarian, prostate, leukemia, lymphoma, multiple myeloma, and brain cancers have been shown to harbor constitutively active Stat3 protein resulting in the expression of protooncogenes. The transcriptionally active Stat3–Stat3 protein homodimer has been extensively targeted as a means to suppress the aberrant Stat3 function in human cancer. This review will outline the recent progress made toward identifying drug-like compounds capable of effectively inhibiting aberrant Stat3 signaling through the disruption of Stat3 protein–protein interactions.
Trade and associated groups in the English tourism policy arena

The role and influence of trade and associated groups in England's tourism policy environment is of increasing importance given recent changes in the consultative processes undertaken by the Department of Culture Media and Sport (the government department sponsoring the tourism industry in Parliament). Yet researchers working within the realm of tourism studies have paid little attention to their characteristics, objectives and tactics. This article, therefore, sets out to address these issues by drawing on the results of phase one of a two-phase research project into the influence of trade and associated groups on policy development. The article reports the findings of a survey into the objectives and tactics used by the groups in policy communications and links this to structural changes in the landscape of the tourism policy. In doing this it suggests how certain relationships have developed between government and groups, how groups collaborate on policy issues and how this may have influenced the direction of tourism policy in the England. Using the results of this research and an analysis of government policy related announcements over the past two years we hypothesise on how successful the groups have been to data, and proposes areas for future research. Copyright © 2001 John Wiley & Sons, Ltd.