Miracle-dz/UniFAR-FTUs huggingface dataset:
Origin and genetic structure of a recovering bobcat (Lynx rufus) population

Genetic analyses can provide important insights into the demographic processes that underlie recovering populations of mammals of conservation concern such as felid species. To better understand the recent and rapid recovery of bobcats (Lynx rufus (Schreber, 1777)) in Ohio, we analyzed samples from four states in the lower Great Lakes Region using 12 microsatellite DNA loci and a portion of the mtDNA control region. Our results showed that a newly established population of bobcats in the eastern part of Ohio was genetically distinct from a multistate population distributed across Kentucky, southern Ohio, West Virginia, and western Pennsylvania. There was no direct genetic evidence of a bottleneck or inbreeding in this population. A lack of private alleles and only slightly lower levels of allelic richness and heterozygosity compared with its neighbors suggest that the eastern Ohio population likely originated from the migration of relatively large numbers of individuals from a source population rather tha.
Towards a Business-Pattern Approach for UML Models Derivation from Business Process Models

Business processes are considered as first class business assets in nowadays organizations. They are often specified using BPMN language. To automate business processes, software specialists specify the information systems that support them with the use of languages like UML. This paper aims to bridge the gap between the organization's business processes and the information systems that support them. It proposes a model-driven development method that automatically generates detailed UML domain models from business process models expressed in BPMN. Our approach is based on business patterns. It consists of three main transformations: the first transformation extracts the process value chain, the second transformation builds UML domain models for each process in the value chain, and the third transformation elaborates the UML models. We developed a proof-of-concept prototype tool using the Eclipse modeling ecosystem. We tested our approach on a set of business processes from the Enterprise Resource Planning literature. The results showed computational feasibility and the conceptual soundness of the approach.
ECMO cannula review

This paper reviews the basic fluid dynamics underlying extracorporeal membrane oxygenation (ECMO) cannula design. General cannula features and their effect on flow are discussed and the specific requirements of different ECMO circuits are explained. The current commercially available cannula options for veno-arterial and veno-venous circuits are reviewed and the main characteristics presented.
Revisitando o technology readiness index (TRI) no Brasil: Uma década depois

Em 2003, Souza e Luce avaliaram a aplicabilidade do Technology Readiness Index (TRI) no Brasil, a partir do instrumento proposto por Parasuraman (2000) e Parasuraman e Colby (2001). Ao longo dos anos, o instrumento vem sendo amplamente utilizado, o que pressupoe uma atencao especial, ja que nesses anos houve uma significativa mudanca de comportamento no que tange a prontidao para tecnologia dos consumidores. Destarte, este artigo propoe-se a (re)avaliar, especialmente da estrutura interna, do TRI. O instrumento proposto por Souza e Luce (2003) foi replicado com 992 consumidores brasileiros. Efetuaram-se analises univariadas e multivariadas. Nao foi possivel obter um ajuste adequado do modelo e discutiu-se a instabilidade da escala. Os resultados sugerem que a amostra e mais propensa a tecnologia do que as amostras estudadas anteriormente, de forma a questionar o real sentido da escala para determinados publicos na atualidade.
Increased Postnatal Cardiac Hyperplasia Precedes Cardiomyocyte Hypertrophy in a Model of Hypertrophic Cardiomyopathy

Rationale: Hypertrophic cardiomyopathy (HCM) occurs in ~0.5% of the population and is a leading cause of sudden cardiac death (SCD) in young adults. Cardiomyocyte hypertrophy has been the accepted mechanism for cardiac enlargement in HCM, but the early signaling responsible for initiating hypertrophy is poorly understood. Mutations in cardiac myosin binding protein C (MYBPC3) are among the most common HCM-causing mutations. Ablation of Mybpc3 in an HCM mouse model (cMyBP-C−/−) rapidly leads to cardiomegaly by postnatal day (PND) 9, though hearts are indistinguishable from wild-type (WT) at birth. This model provides a unique opportunity to explore early processes involved in the dramatic postnatal transition to hypertrophy. Methods and Results: We performed microarray analysis, echocardiography, qPCR, immunohistochemistry (IHC), and isolated cardiomyocyte measurements to characterize the perinatal cMyBP-C−/− phenotype before and after overt hypertrophy. cMyBP-C−/− hearts showed elevated cell cycling at PND1 that transitioned to hypertrophy by PND9. An expanded time course revealed that increased cardiomyocyte cycling was associated with elevated heart weight to body weight ratios prior to cellular hypertrophy, suggesting that cell cycling resulted in cardiomyocyte proliferation. Animals heterozygous for the cMyBP-C deletion trended in the direction of the homozygous null, yet did not show increased heart size by PND9. Conclusions: Results indicate that altered regulation of the cell cycling pathway and elevated proliferation precedes hypertrophy in the cMyBP-C−/− HCM model, and suggests that increased cardiomyocyte number contributes to increased heart size in cMyBP-C−/− mice. This pre-hypertrophic period may reflect a unique time during which the commitment to HCM is determined and disease severity is influenced.
Optimal bidding in spot instance market

Amazon introduced Spot Instance Market to utilize the idle resources of Amazon Elastic Compute Cloud (EC2) more efficiently. The price of a spot instance changes dynamically according to the current supply and demand for cloud resources. Users can bid for a spot instance and the job request will be granted if the current spot price falls below the bid, whereas the job will be terminated if the spot price exceeds the bid. In this paper, we investigate the problem of designing a bidding strategy from a cloud service broker's perspective, where the cloud service broker accepts job requests from cloud users, and leverages the opportunistic yet less expensive spot instances for computation in order to maximize its own profit. In this context, we propose a profit aware dynamic bidding (PADB) algorithm, which observes the current spot price and selects the bid adaptively to maximize the time average profit of the cloud service broker. We show that our bidding strategy achieves a near-optimal solution, i.e., (1-∈) of the optimal solution to the profit maximization problem, where ∈ can be arbitrarily small. The proposed dynamic bidding algorithm is self-adaptive and requires no a priori statistical knowledge on the distribution of random job sizes from cloud users.
Optimal INR level in Thai atrial fibrillation patients who were receiving warfarin for stroke prevention in Thailand.

OBJECTIVE To determine the optimal International Normalized Ratio (INR) level in Thai atrialfibrillation (AF) patients who received warfarin. MATERIAL AND METHOD This retrospective study enrolled 230 AF patients that received warfarin in Siriraj Hospital between January 1, 2005 andDecember 31, 2009 and collected the INR level at the time of the event, the numbers of ischemic stroke, and bleeding events. The incidence density of ischemic stroke or bleeding events was calculated by dividing the number of ischemic stroke or bleeding event in each INR level with the summation of the time that each patient stayed in each INR group. The patients with a prosthetic valve were excluded. The INR range was classified into six groups (less than 1.5, 1.5 to 1.9, 2.0 to 2.4, 2.5 to 2.9, 3.0 to 3.4, and greater than 3.4). The optimal INR level was defined as the lowest incidence density of ischemic stroke and bleeding complications. RESULTS Two hundred thirty AF patients (the mean age 68 ± 12 years) were enrolled, contributing to 737.54 patient-years of observation period. Of the 230 patients, nine patients experienced 12 ischemic events (1.6 per 100 patient-years) and 54 patients experienced 57 bleeding events (7.7 per 100 patient-years). The percentage of patient-time spent within INR 2 to 3, INR less than 2, and INR more than 3 were 40.75, 46.22, and 13.03%, respectively. The INR level more than 3.4 increased both major and minor bleeding events (p = 0.001). The INR level of 3.0 to 3.4 increased the minor bleeding events (p = 0.03). The INR level less than 1.5 increased incidence of ischemic stroke (p = 0.03). The overall event rate was lowest in the INR range from 1.5 to 2.9, which is significantly different from that of lNR more than 2.9 (p < 0.0001), but trend lower than INR less than 1.5 without being statistically significant (p = 0.198). CONCLUSION An INR of 1.5-2.9 appeared to be associated with the lowest incidence rate of bleeding or ischemic stroke in a cohort of Thai AFpatients receiving warfarin therapy for stroke prevention.
Spatial models for architectural heritage in urban database context

Despite the GIS (Geographic Information Systems/Geospatial Information Systems) have been provided with several applications to manage the two-dimensional geometric information and arrange the topological relations among different spatial primitives, most of these systems have limited capabilities to manage the three-dimensional space. Other tools, such as CAD systems, have already achieved a full capability of representing 3D data. Most of the researches in the field of GIS have underlined the necessity of a full 3D management capability which is not yet achieved by the available systems (Rahman, Pilouk 2008) (Zlatanova 2002). First of all to reach this goal is important to define the spatial data model, which is at the same time a geometric and topological model and so integrating these two aspects in relation to the database management efficiency and documentation purposes. The application field on which these model can be tested is the spatial data managing of Architectural Heritage documentation, to evaluate the pertinence of these spatial models to the requested scale for the needs of such a documentation. Most of the important aspects are the integration of metric data originated from different sources and the representation and management of multiscale data. The issues connected with the representation of objects at higher LOD than the ones defined by the CityGML will be taken into account. The aim of this paper is then to investigate which are the favorable application of a framework in order to integrate two different approaches: architectural heritage spatial documentation and urban scale spatial data management.
A Method for Quantitative Determination of the Number of Magnetosomes in Magnetotactic Bacteria by a Spectrophotometer

A method for quantitative determination of the number of magnetosomes in magnetotactic bacteria (MTB) was developed in this paper. Using a magnetism measuring system that composed of a common laboratory spectrophotometer and an electromagnetic system, the relation between the Rmag of the MTB solution and the magnetic flux density of the applied magnetic field could be measured. The formula to calculate the percentage distribution of the bacteria with different numbers of magnetosomes was deduced in this paper, which depended on the Rmag curve under different magnetic flux densities. The related parameters were obtained by fitting the real measured results. Finally, the distribution of the MTB with different numbers of magnetosomes was detected by the proposed method.
Anatomical Landmark Tracking by One-shot Learned Priors for Augmented Active Appearance Models

For animal bipedal locomotion analysis, an immense amount of recorded image data has to be evaluated by biological experts. During this time-consuming evaluation single anatomical landmarks have to be annotated in each image. In this paper we reduce this effort by automating the annotation with a minimum level of user interaction. Recent approaches, based on Active Appearance Models, are improved by priors based on anatomical knowledge and an online tracking method, requiring only a single labeled frame. However, the limited search space of the online tracker can lead to a template drift in case of severe self-occlusions. In contrast, we propose a one-shot learned tracking-by-detection prior which overcomes the shortcomings of template drifts without increasing the number of training data. We evaluate our approach based on a variety of real-world X-ray locomotion datasets and show that our method outperforms recent state-of-the-art concepts for the task at hand.
Texture Display Mouse: Vibrotactile Pattern and Roughness Display

This paper presents a novel haptic mouse that can be used as a human-computer interface and offers the capability of displaying properties such as patterns, gratings, and roughness. A small planar-distributed pin array is developed. Since the tactile display unit is small enough to be embedded into a computer mouse, we developed a texture display mouse. The performance of its texture display capability was verified. In addition, two psychophysical experiments have been conducted in order to ascertain the influence of vibrotactile stimuli. The first experiment showed that vibrational stimuli could be effective in the perception of patterns while from the second experiment, the functional relation between perceived roughness and component of vibrotactile stimuli was obtained. The experimental results have been applied to the development of a test-bed program.
Genome Wide Mapping of Peptidases in Rhodnius prolixus: Identification of Protease Gene Duplications, Horizontally Transferred Proteases and Analysis of Peptidase A1 Structures, with Considerations on Their Role in the Evolution of Hematophagy in Triatominae

Triatominae is a subfamily of the order Hemiptera whose species are able to feed in the vertebrate blood (i.e., hematophagy). This feeding behavior presents a great physiological challenge to insects, especially in Hemipteran species with a digestion performed by lysosomal-like cathepsins instead of the more common trypsin-like enzymes. With the aim of having a deeper understanding of protease involvement in the evolutionary adaptation for hematophagy in Hemipterans, we screened peptidases in the Rhodnius prolixus genome and characterized them using common blast (NCBI) and conserved domain analyses (HMMER/blast manager software, FAT, plus PFAM database). We compared the results with available sequences from other hemipteran species and with 18 arthropod genomes present in the MEROPS database. Rhodnius prolixus contains at least 433 protease coding genes, belonging to 71 protease families. Seven peptidase families in R. prolixus presented higher gene numbers when compared to other arthropod genomes. Further analysis indicated that a gene expansion of the protease family A1 (Eukaryotic aspartyl protease, PF00026) might have played a major role in the adaptation to hematophagy since most of these peptidase genes seem to be recently acquired, are expressed in the gut and present putative secretory pathway signal peptides. Besides that, most R. prolixus A1 peptidases showed high frequencies of basic residues at the protein surface, a typical structural signature of Cathepsin D-like proteins. Other peptidase families expanded in R. prolixus (i.e., C2 and M17) also presented significant differences between hematophagous (higher number of peptidases) and non-hematophagous species. This study also provides evidence for gene acquisition from microorganisms in some peptidase families in R. prolixus: (1) family M74 (murein endopeptidase), (2) family S29 (Hepatitis C virus NS3 protease), and (3) family S24 (repressor LexA). This study revealed new targets for studying the adaptation of these insects for digestion of blood meals and their competence as vectors of Chagas disease.
A Meta-Analysis of Adalimumab for Fistula in Crohn's Disease

Purpose This study aimed to evaluate the therapeutic value of adalimumab (ADA) for fistula in Crohn's disease (CD). Methods A computerized search of electronic databases, including PubMed, Web of Science, Embase, Google scholar, and the Cochrane Library from 2000 to October 2016, was performed. Randomized controlled trials (rcts) or nonrandomized controlled trials (n-rcts) were included in this article to evaluate the role of ADA in the management of fistula in CD. The methodological index for nonrandomized studies (MINORS evaluation tools) was used to assess the quality of every study. Result Overall, seven studies and 379 patients comforted to the inclusion criteria of this meta-analysis. The result showed that 36% (95% CI: 0.31–0.41) of patients with complete fistula closure and 31% (95% CI: 0.031–0.61) of patients with partial response were received in CD with ADA treatment. Conclusion We concluded that ADA is effective and safe for the treatment of fistula in CD according to current evidence.
Cyclophosphamide as a potential chemosterilant for harmful snails.

Cyclophosphamide induced changes in the ovotestis of the snail Lymnaea acuminata, the vector of the giant liverflukes Fasciola hepatica and Fasciola gigantica were studied in order to explore potential of the drug as a chemosterilant for snails. The drug caused a dose dependent reduction in the levels of DNA, RNA and proteins and the activity of the enzyme alkaline phosphatase. It increased the activity of acid phosphatase and the levels of total free amino acids in the ovotestis. While the animals showed nearly total recovery in RNA and DNA levels 7 days after termination of drug treatment, changes produced in protein, amino acid levels and phosphatase activity did not show any recovery. It appears that cyclophosphamide, while affecting its primary targets i.e. DNA and RNA, irreversibly inhibits protein synthesis through other cellular enzymes as well.
Research of classification hypersurface based on tangent circular arc smooth SVM (TAC-SSVM)

The lack of efficient heuristic information is the fundamental reason that causes the low effectiveness of currently used approaches for extracting symbolic rules. Classification hypersurface are direct heuristic information for selecting attributes. In SVM (support vector machine), classification hypersurface is emphasized because of the direct induction of the support vectors. In this paper, a new SVM model and a new measurement method of the classification power of attributes on the basis of the characteristics of the classification hypersurfaces based on the proposed SVM model is presented. The experimental results prove that the approach proposed can improve the validity of the extracted rules remarkably compared with other rule extracting approach.
Applications of myeloid‐specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity

Myeloid lineage cells contribute to innate and acquired immunity, homeostasis, wound repair, and inflammation. There is considerable interest in manipulation of their function in transgenic mice using myeloid‐specific promoters. This review considers the applications and specificity of some of the most widely studied transgenes, driven by promoter elements of the lysM, csf1r, CD11c, CD68, macrophage SRA, and CD11b genes, as well as several others. Transgenes have been used in mice to generate myeloid lineage‐specific cell ablation, expression of genes of interest, including fluorescent reporters, or deletion via recombination. In general, the specificity of such transgenes has been overinterpreted, and none of them provide well‐documented, reliable, differential expression in any specific myeloid cell subset, macrophages, granulocytes, or myeloid DCs. Nevertheless, they have proved valuable in cell isolation, functional genomics, and live imaging of myeloid cell behavior in many different pathologies.
ROME AND THE EAST. PRODUCTION OF ROMAN PROVINCIAL SILVER COINAGE FOR CAESAREA IN CAPPADOCIA UNDER VESPASIAN, AD 69–79

Summary During the first three centuries AD several eastern provinces of the Roman empire produced silver coinages of specifically local denominations and types. It has been claimed that at certain periods the mint of Rome was employed to strike some of these coinages, rather than the provincial mints to which the coins are traditionally attributed. This claim is based mainly on stylistic observations, but because style is regarded as subjective, some other form of evidence to support these observations is desirable. In this paper three types of coin are submitted to metallurgical analysis: silver denarii struck at Rome; Roman-style provincial silver coinage; and ‘local’style provincial silver coinage. The aim is to discover whether the Rome-style and ‘local’style coins have different trace element profiles, and whether these might indicate different ore sources or refining techniques. The results are then compared with Roman denarii to see whether there are any similarities between the denarii and the Rome-style provincial silver coins.
a , 11 , 11-Trimethyl-10 a , 11-dihydro-8 H-benzo [ e ] imidazo [ 1 , 2-a ] indol-9 ( 10 H )-one

The alkylation of 1,1,2-trimethyl-1H-benzo[e]indole with 2-chloroacetamide, followed by work-up of the reaction mixture with a base and the subsequent treatment of a crude product with acetic acid gives 10a,11,11-trimethyl-10a,11-dihydro-8H-benzo[e]imidazo[1,2-a]indol-9(10H)-one. The structure assignments were based on data from 1H, 13C, and 15N-NMR spectroscopy. The optical properties of the obtained compound were studied by UV–Vis and fluorescence spectroscopy.
Chromosomal deletions and K‐ras gene mutations in human endometrial carcinomas

Forty‐two endometrial carcinomas of various stages of progression were analyzed to search for loss of chromosomal regions and for point mutations of ras genes and amplification of Int‐2 gene. This approach is particularly favorable for observation of genetic events and their significance in the process of neoplastic conversion by considering the clinico‐pathological characteristics of each tumor. At least 3 genetic events, including 18q, 17p deletions, and point mutations at codon 12 of the K‐ras gene, are implicated in the development of endometrial carcinomas. Likely targets for allelic losses on chromosomes 18q and 17p are the DCC gene and the p53 gene sequences, respectively. Overall numbers of allelic losses in individual tumors appeared to increase in case of advanced stage tumors, thereby indicating the association of allelic loss accumulation with tumor progression. The genetic features seen in 2 juveniletype adenocarcinomas and 2 clear‐cell carcinomas suggested the possibility that etiological factors providing selective pressure for particular mutation sub‐sets during carcinogenesis are probably heterogeneous.
5-Bromophthalazine hemihydrate

The title compound, C8H5BrN2·0.5H2O, is a phthalazine derivative synthesized from 3-bromobenzene-1,2-dicarbaldehyde and hydrazine. The molecule is essentially planar, the deviation from the mean plane of the phthalazine ring being 0.015 (3) Å. The O atom of the solvent water molecule is situated on a twofold rotation axis. In the crystal, O—H⋯N hydrogen bonds and short N⋯Br [2.980 (3) Å] contacts lead to the formation of a two-dimensional network parallel to (101).