Miracle-dz/UniFAR-FTUs huggingface dataset:
The case for academic detailing with nurse practitioners.

In the age of increasing time demands on nurse practitioners (NPs) and rapidly evolving changes to the evidence base underpinning clinical practice, there is a clear need to provide clinicians with continuing professional development in an effective and time-efficient manner. Academic detailing (also called educational outreach) combines the communication and marketing skills of industry with the intellectual rigor of academe to construct and deliver medical education programs. Trained facilitators visit healthcare practitioners one-on-one in their place of work to deliver key clinical messages on a defined topic of interest and relevance to the provider. The key messages are often phrased as succinct action statements to help support behavior change. The sessions between facilitator and provider are highly interactive and seek to elicit the specific needs of the individual provider, as well as discussing the key messages of the topic. The overall goal of academic detailing programs is to facilitate good clinical decision making by providing clinicians and patients with evidence-based, practical, clinically relevant, and independent/unbiased information that takes a biopsychosocial approach. An extensive review of the biomedical literature and writing of de novo clinical reviews help to elicit the key messages and support each educational topic. An important aspect of successful academic detailing programs is to establish how outcomes from clinical trials should influence real-life clinical practice. In particular, this has involved determining the comparative effectiveness of active therapies in relation to clinical outcomes rather than surrogate markers. We have been providing academic detailing programs to physicians in the United States and Australia for more than 15 years, and more recently to NPs, particularly in their role as prescribers. The programs are universally well-received, uptake is high, and retention rates approach 100%. A number of themes that clinicians value in the programs consistently emerge in their feedback: (a) the independent noncommercial nature of the information provided; (b) the clinical relevance of the key messages framed as action statements; (c) a focus on comparative effectiveness of active therapies, not just therapy versus placebo; (d) a willingness to discuss individual clinical needs; (e) a translation of how clinical trial results should influence clinical practice; and (f) the individualized oneon-one visit in their workplace. Rationale for academic detailing
Spectral Characterization of Mini Concentrator Optics for its Use With MJ Cells

New concepts of concentrator modules have been proposed in the last years based on refractive optics and cost effective III-V devices at high concentration levels. The small size of the cells, the high concentration ratio and the compact aspect of the optics are some of the particular characteristics of these C-systems. In this paper we face out the optical characterization of these mini concentrator systems. A new method is proposed for indoor characterization of the spectrally dependent optical efficiency, which allows to obtain the integrated optical efficiency with any light spectrum and to calculate the electrical efficiency with multi-junction solar cells. Influence of the spectral transmittance of an optics on 2J cells current mismatch has been assessed
Threonine Locus of Escherichia coli K-12: Genetic Structure and Evidence for an Operon

Three genes, thrA, thrB, and thrC, were previously defined and localized in the threonine locus of Escherichia coli K-12. thrA, thrB, and thrC specify the enzymes aspartokinase I-homoserine dehydrogenase I, homoserine kinase, and threonine synthetase, respectively. A complementation analysis of the threonine cluster using derivatives of a lambda phage carrying the threonine genes (λdthrc) demonstrates that: (i) thrB and thrC each consist of a single cistron; and (ii) thrA is composed of two cistrons, thrA1 and thrA2, although it specifies a single polypeptide chain. thrA1 and thrA2 correspond to aspartokinase I and homoserine dehydrogenase I, respectively. Their relative order is established. The demonstration of polar effects of mutations (nonsense or induced by phage Mu) in thrA and thrB is taken as evidence for the existence of a thrA thrB thrC operon, transcribed in this order.
Site-Specific Release of Nascent Chains from Ribosomes at a Sense Codon

ABSTRACT “2A” oligopeptides are autonomous elements containing a D(V/I)EXNPGP motif at the C terminus. Protein synthesis from an open reading frame containing an internal 2A coding sequence yields two separate polypeptides, corresponding to sequences up to and including 2A and those downstream. We show that the 2A reaction occurs in the ribosomal peptidyltransferase center. Ribosomes pause at the end of the 2A coding sequence, over the glycine and proline codons, and the nascent chain up to and including this glycine is released. Translation-terminating release factors eRF1 and eRF3 play key roles in the reaction. On the depletion of eRF1, a greater proportion of ribosomes extend through the 2A coding sequence, yielding the full-length protein. In contrast, impaired eRF3 GTPase activity leads to many ribosomes failing to translate beyond 2A. Further, high-level expression of a 2A peptide-containing protein inhibits the growth of cells compromised for release factor activity and leads to errors in stop codon recognition. We propose that the nascent 2A peptide interacts with ribosomes to drive a highly unusual and specific “termination” reaction, despite the presence of a proline codon in the A site. After this, the majority of ribosomes continue translation, generating the separate downstream product.
Fast range image segmentation using high-level segmentation primitives

In this paper we present a novel algorithm for very fast segmentation of range images into both planar and curved surface patches. In contrast to other known segmentation methods our approach makes use of high-level features (curve segments) as segmentation primitives instead of individual pixels. This way the amount of data can be significantly reduced and a very fast segmentation algorithm is obtained. The proposed algorithm has been tested on a large number of real range images and demonstrated good results. With an optimized implementation our method has the potential to operate in quasi real-time (a few range images per second).
Clustering-based Method for Positive and Unlabeled Text Categorization Enhanced by Improved TFIDF

PU learning occurs frequently in Web pages classification and text retrieval applications because users may be interested in information on the same topic. Collecting reliable negative examples is a key step in PU (Positive and Unlabeled) text classification, which solves a key problem in machine learning when no labeled negative examples are available in the training set or negative examples are difficult to collect. Thus, this paper presents a novel clustering-based method for collecting reliable negative examples (CCRNE). Different from traditional methods, we remove as many probable positive examples from unlabeled set as possible, which results that more reliable negative examples are found out. During the process of building classifier, a novel TFIDF-improved feature weighting approach, which reflects the importance of the term in the positive and negative training examples respectively, is presented to describe documents in the Vector Space Model. We also build a weighted voting classifier by iteratively applying the SVM algorithm and implement OCS (One-class SVM), PEBL (Positive Example Based Learning) and 1-DNFII (Constrained 1-DNF) methods used for comparison. Experimental results on three real-world datasets (Reuters Corpus Volume 1 (RCV1), Reuters-21578 and 20 Newsgroups) show that our proposed C-CRNE extracts more reliable negative examples than the baseline algorithms with very low error rates. And our classifier outperforms other state-of-art classification methods from the perspective of traditional performance metrics.
Anti‐CD20 monoclonal antibody (Rituximab) for life‐threatening hemolytic–uremic syndrome

Abstract: Rituximab is a chimaeric monoclonal antibody directed against the CD20 antigen. It has been successfully used in B‐cell malignancy and its efficacy in the treatment of in autoimmune hemolytic anemia and other autoimmune diseases is being investigated. There are also few case reports of its success in thrombotic thrombocytopenic purpura, but no reports of its use in hemolytic–uremic syndrome (HUS). We report a 36‐year‐old patient who had lost the function of her native kidneys secondary to HUS. After more than 1 year in clinical remission, she received a living unrelated kidney transplant. This immediately precipitated a severe relapse of HUS. The process was abrogated but not completely inactivated, despite over 40 plasma exchange treatments. Consequently, she was given Rituximab in courses of two to three doses, each dose 375 mg/m2, at weekly intervals with remarkable stabilization of her disease for approximately 6 months.
Analyzing effective municipal solid waste recycling programs: the case of county-level MSW recycling performance in Florida, USA

Municipal solid waste (MSW) recycling performance, both nationally and in Florida, USA, has shown little improvement during the past decade. This research examines variations in the MSW recycling program performance in Florida counties in an attempt to identify effective recycling programs. After reviewing trends in the MSW management literature, we conducted an empirical analysis using cross-sectional multiple regression analysis. The findings suggest that the convenience-based hypothesis was supported by showing that curbside recycling had a positive effect on MSW recycling performance. Financial (cost-saving) incentive-based hypotheses were partially supported meaning that individual level incentives can influence recycling performance. Citizen environmental concern was found to positively affect the amount of county recycling, while education and political affiliation yielded no significant results. In conclusion, this article discusses the implications of the findings for both academic research and practice of MSW recycling programs.
An abrupt change in the African monsoon at the end of the Younger Dryas

High‐resolution studies of variations in the elemental and stable carbon‐ and nitrogen‐isotope composition of organic matter in cores from Lakes Malawi, Tanganyika, and Bosumtwi (tropical Africa) indicate an abrupt change in the wind‐driven circulation of these lakes that, within the limits of available chronologies, was contemporaneous with the end of the Younger Dryas in the northern hemisphere. The change was also coincident with shifts in surface winds recorded in cores from off the west and northeast coasts of Africa. A range of other proxies indicate that these changes in wind regime were accompanied by a marked increase in precipitation in the northern tropics. Africa south of ∼5°–10°S, on the other hand, initially suffered drought conditions. Together, the evidence suggests an abrupt northward translation of the African monsoon system at circa 11.5 ± 0.25 ka B.P. The data assembled here contribute to a growing body of work showing that the Younger Dryas was a major climatic excursion in tropical Africa. Furthermore, they add substance to recent suggestions that climatic events in the southern hemisphere may have played a significant role in the abrupt demise of the Younger Dryas.
Limitations of shift-and-ratio based L/sub eff/ extraction techniques for MOS transistors with halo or pocket implants

The shift-and-ratio method has been considered as one of the most accurate and consistent techniques for extracting the effective channel-length of the MOS transistor. This method assumes the effective mobility of a long channel and a short channel transistor to be equal. Scaling down the MOS transistor urges the need of including halo (or pocket) implants in the fabrication process. Due to this implant, however, the short channel MOSFET features a degraded effective mobility compared to the long channel reference device. This affects the channel-length extraction and results in unrealistic high values for the extracted effective channel-length for deep submicron transistors with high-dose halo (or pocket) implants.
Frequency of osteopenia and associated risk factors among young female students.

OBJECTIVE To find out the frequency of osteopenia and associated risk factors among young female students. METHODS This observational, cross-sectional study was conducted at the Dow University of Health Sciences, Karachi, from August 2011 to January 2012, and comprised young female students. Convenient sampling method was used. Age, residence, sun exposure, menstrual status, level of physical activity, exercise, vitamin D, calcium intake were variables of interest. Dual-energy X-ray absorptiometry scan was used to measure bone mineral density on the lumbar spine, hip, femur and distal forearm. SPSS 16 was used for data analysis. RESULTS A total of 100(76.9%) students were included in this study. The age range was 20-30 years. Overall,70(70%)participants were osteopenic, while 30(30%) were normal. Age<25 years, living with less exposure to sun, less physical activity and diet low in calcium and vitamin D were common risk factors. CONCLUSIONS The frequency of osteopenia was significantly high among young female students.
Recent developments in amperometric detection for microchip capillary electrophoresis

The interest in microfluidic devices has increased considerably over the past decade due to the numerous advantages of working within a miniature, microfabricated format. This review focuses on recent advances in coupling amperometric detection with microchip capillary electrophoresis (CE). Advances in electrochemical cell design, isolation of the detector from the separation field, and integration of both pre‐ and postseparation reaction chambers are discussed. The use of microchip CE with amperometric detection for enzyme/immunoassays, clinical and environmental assays, and the determination of neurotransmitters is described.
Using NavCon for conceptual navigation in web documents

This paper presents conceptual navigation and NavCon, an architecture that implements this navigation in World Wide Web pages. NavCon architecture makes use of ontology as metadata to contextualise user's search for information. Conceptual navigation is a technique to browse websites within a context. Context filters relevant retrieved information, and it drives user's navigation through paths that meet his needs. Based on ontologies, NavCon automatically inserts conceptual links in web pages. These links permit the users to access a graph representing concepts and their relationships. Browsing this graph, it is possible to reach documents associated with user's desired ontology concept.
Diagnosis and prognosis of early-onset intrahepatic cholestasis of pregnancy: a prospective study

Abstract Objective: To explore the gestational age of early-onset intrahepatic cholestasis (ICP) of pregnancy, and to analyze the relationship between the clinical biochemical indices and pregnancy outcomes in order to arrive at a reasonable diagnosis and administer appropriate treatment. Design: This is a retrospective clinical study. Population or sample: We selected 47,260 pregnant women who received prenatal care and underwent childbirth at the International Peace Maternity and Child Health Hospital affiliated to Shanghai Jiao Tong University from January 2014 to December 2016 for participating in this study. Of these 47,260 women, 407 developed ICP. Methods: To calculate the gestational week cutoff between early- and late-onset ICP by the receiver-operating characteristic (ROC) curve and Youden’s index. Two independent samples t tests and chi square test were used to compare the differences in biochemical indices and pregnancy outcomes between the two groups. Results: We found that 34 weeks is the most appropriate cutoff gestational age for the diagnosis of early-onset ICP. Early-onset ICP is characterized by early onset, long disease duration and a higher incidence of preterm labor, fetal distress, and fetal low birth weight compared to late-onset ICP. Conclusions: Thirty-four weeks is the most appropriate cutoff gestational age for the diagnosis of early-onset ICP. And to reduce the adverse pregnancy outcomes in cases of early-onset ICP, we suggest prolonging gestation up to 37 weeks as far as possible before selecting iatrogenic birth.
Performance Analysis for LDPC-Coded Modulation in MIMO Multiple-Access Systems

We consider a low-density parity-check (LDPC)-coded modulation scheme in multi-input multi-output (MIMO) multiple-access systems. The receiver can be regarded as a serially concatenated iterative detection and decoding scheme, where the LDPC decoders perform the role of outer decoder and the multiuser demapper does that of the inner decoder. In this paper, we investigate the performance of the scheme with simulation results and bounds. Union upper bounds are derived, which can be used as additional means to evaluate the performance of the MIMO multiple-access system.
Year : 2014 Methane Emission by Camelids

Methane emissions from ruminant livestock have been intensively studied in order to reduce contribution to the greenhouse effect. Ruminants were found to produce more enteric methane than other mammalian herbivores. As camelids share some features of their digestive anatomy and physiology with ruminants, it has been proposed that they produce similar amounts of methane per unit of body mass. This is of special relevance for countrywide greenhouse gas budgets of countries that harbor large populations of camelids like Australia. However, hardly any quantitative methane emission measurements have been performed in camelids. In order to fill this gap, we carried out respiration chamber measurements with three camelid species (Vicugna pacos, Lama glama, Camelus bactrianus; n = 16 in total), all kept on a diet consisting of food produced from alfalfa only. The camelids produced less methane expressed on the basis of body mass (0.3260.11 L kg-1 d-1) when compared to literature data on domestic ruminants fed on roughage diets (0.5860.16 L kg-1 d-1). However, there was no significant difference between the two suborders when methane emission was expressed on the basis of digestible neutral detergent fiber intake (92.7633.9 L kg-1 in camelids vs. 86.2612.1 L kg-1 in ruminants). This implies that the pathways of methanogenesis forming part of the microbial digestion of fiber in the foregut are similar between the groups, and that the lower methane emission of camelids can be explained by their generally lower relative food intake. Our results suggest that the methane emission of Australia’s feral camels corresponds only to 1 to 2% of the methane amount produced by the countries’ domestic ruminants and that calculations of greenhouse gas budgets of countries with large camelid populations based on equations developed for ruminants are generally overestimating the actual levels. DOI: https://doi.org/10.1371/journal.pone. 0094363 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-95115 Published Version Originally published at: Dittmann, Marie T; Runge, Ullrich; Lang, Richard A; Moser, Dario; Galeffi, Cordula; Kreuzer, Michael; Clauss, Marcus (2014). Methane Emission by Camelids. PLoS ONE, 9(4):e94363. DOI: https://doi.org/10.1371/journal.pone. 0094363 Methane Emission by Camelids Marie T. Dittmann*, Ullrich Runge, Richard A. Lang, Dario Moser, Cordula Galeffi, Michael Kreuzer, Marcus Clauss 1 Clinic for Zoo Animals, Exotic Pets and Wildlife, Vetsuisse Faculty Zurich, University of Zurich, Zurich, Switzerland, 2 ETH Zurich, Institute for Agricultural Sciences, Zurich, Switzerland, 3 Kamelhof Olmerswil, Neukirch/Thur, Switzerland, 4 Cochranton Veterinary Hospital, Cochranton, Pennsylvania, United States of America, 5 Zoological Institute, University of Basel, Basel, Switzerland, 6 Zurich Zoo, Zurich, Switzerland
A flexible path selection procedure for path delay fault testing

We describe a path selection procedure that selects target faults for path delay fault test generation. Since large numbers of path delay faults may be untestable, the proposed procedure does not select a fixed set of paths. Instead, it provides compactly represented subsets of paths, referred to as super-paths, and allows the test generation procedure to select one path out of each subset based on testability considerations.
Age and gender interactions in ultra-endurance performance : insight from triathlon Lepers

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Age and gender interactions in ultraendurance performance: insight from the triathlon. Romuald Lepers, Na Maffiuletti
Neural Responses to Rapid Facial Expressions of Fear and Surprise

Facial expression recognition is mediated by a distributed neural system in humans that involves multiple, bilateral regions. There are six basic facial expressions that may be recognized in humans (fear, sadness, surprise, happiness, anger, and disgust); however, fearful faces and surprised faces are easily confused in rapid presentation. The functional organization of the facial expression recognition system embodies a distinction between these two emotions, which is investigated in the present study. A core system that includes the right parahippocampal gyrus (BA 30), fusiform gyrus, and amygdala mediates the visual recognition of fear and surprise. We found that fearful faces evoked greater activity in the left precuneus, middle temporal gyrus (MTG), middle frontal gyrus, and right lingual gyrus, whereas surprised faces were associated with greater activity in the right postcentral gyrus and left posterior insula. These findings indicate the importance of common and separate mechanisms of the neural activation that underlies the recognition of fearful and surprised faces.
HVEM Signaling in Monocytes Is Mediated by Intracellular Calcium Mobilization1

Herpes virus entry mediator (HVEM) is a member of the TNF receptor (TNFR) superfamily and is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Interaction of HVEM with its ligand, LIGHT, costimulates T cells and increases the bactericidal activity of monocytes and neutrophils. The interaction recruits cytoplasmic TNFR-associated factor adaptor proteins to the intracellular domain of HVEM. This leads to NFκB activation as a result of IκBα degradation and/or JNK/AP-1 activation, and ultimately results in the expression of genes required for cell survival, cytokine production, or cell proliferation. In this study, we show that treatment of human monocytes with recombinant human LIGHT (rhLIGHT) induces rapid elevation of intracellular calcium concentration ([Ca2+]i) in a HVEM-specific manner in parallel with TNF-α production, and enhances the bactericidal activities of monocytes. Immunoprecipitation and Western blotting analyses revealed phosphorylation of phospholipase Cγ1 (PLCγ1) but not PLCγ2. rhLIGHT-induced Ca2+response was completely abolished by silencing PLCγ1, or preincubating monocytes with PLC inhibitors, antagonists of the inositol-1,4,5-triphosphate receptor, or [Ca2+]i chelators. Furthermore, these PLC/Ca2+ inhibitors also blocked rhLIGHT-mediated IκBα degradation, generation of reactive oxygen species, TNF-α production and the bactericidal activities of monocytes. Our results indicate that Ca2+is a downstream mediator of the LIGHT/HVEM interaction in monocytes.