Miracle-dz/UniFAR-FTUs huggingface dataset:
Universities and article copyright

In all the debates about copyright and intellectual property in recent years, the battle lines have tended to be drawn between librarians and publishers. This neglected what in some ways is the most important player of all, the employer. There seems little doubt that the university owns the copyright in articles, and universities are beginning seriously to turn their attention to this. Whether the article is in printed and/or electronic form probably makes no difference in law to ownership, but custom and practice are important here. A study has just been completed by the Centre for Educational Systems at Strathclyde University at the request of the Funding Councils to review current practice and benchmark the present position against future action. Higher education has turned itself into big business and as a result is beginning to contemplate more fully how to manage its assets. The total turnover in the sector now exceeds £10 billion pounds per annum. An 'average' university will have a turnover in the region of £120-150 million, less than half of which comes directly from the state. More than half of funds now come from a combination of overseas student fees, competitively tendered research grants, endowment income and intellectual property rights. This last can increasingly represent several millions of pounds and the figure is growing. Quite apart from some of the ownership questions raised below, staff structures are increasingly organized to allow some staff additional research time for the benefit of all. Universities have no other purpose than the creation, dissemination, understanding and development of knowledge, and it is inevitable that intellectual property asset management is an area of growing concern.
Ecophysiology matters: linking inorganic carbon acquisition to ecological preference in four species of microalgae (Chlorophyceae)

The effect of CO2 supply is likely to play an important role in algal ecology. Since inorganic carbon (Ci) acquisition strategies are very diverse among microalgae and Ci availability varies greatly within and among habitats, we hypothesized that Ci acquisition depends on the pH of their preferred natural environment (adaptation) and that the efficiency of Ci uptake is affected by CO2 availability (acclimation). To test this, four species of green algae originating from different habitats were studied. The pH‐drift and Ci uptake kinetic experiments were used to characterize Ci acquisition strategies and their ability to acclimate to high and low CO2 conditions and high and low pH was evaluated. Results from pH drift experiments revealed that the acidophile and acidotolerant Chlamydomonas species were mainly restricted to CO2, whereas the two neutrophiles were efficient bicarbonate users. CO2 compensation points in low CO2‐acclimated cultures ranged between 0.6 and 1.4 μM CO2 and acclimation to different culture pH and CO2 conditions suggested that CO2 concentrating mechanisms were present in most species. High CO2 acclimated cultures adapted rapidly to low CO2 condition during pH‐drifts. Ci uptake kinetics at different pH values showed that the affinity for Ci was largely influenced by external pH, being highest under conditions where CO2 dominated the Ci pool. In conclusion, Ci acquisition was highly variable among four species of green algae and linked to growth pH preference, suggesting that there is a connection between Ci acquisition and ecological distribution.
Possible roles of β‐catenin in evagination of the optic primordium in rat embryos

The roles of β‐catenin in evagination of the optic primordium in rat embryos were studied using immunostaining. High levels of β‐catenin appeared transiently in the evaginating optic primordium. Evagination of the optic primordium was suppressed in embryos treated with LiCl. In deficient optic vesicles of these embryos, accumulation of β‐catenin was decreased. Deficient optic vesicles also showed suppression of cyclin D1 accumulation and bromodeoxyuridine incorporation, no break in the deposition of laminin and type IV collagen at the basement membrane (BM) and prevention of the change in distribution of microtubles and microfilaments. These results suggest that β‐catenin regulates cell proliferation, breakdown of BM and changes in cell shape in the evaginating optic primordium to cause optic vesicle formation.
Lectures de Mélissos : Édition, Traduction et Interprétation des témoignages sur Mélissos de Samos

Notre these consiste en une edition et traduction des temoignages sur le philosophe presocratique Melissos de Samos dans l’Antiquite, et un commentaire qui se concentre sur l’histoire de l’interpretation de ce penseur. Notre objectif est de montrer comment Melissos a ete compris par les auteurs anciens en fonction de leur perspective et des connaissances dont ils disposaient, et de presenter les grandes orientations de cette lecture a travers l’Antiquite. Une telle etude est particulierement interessante pour Melissos etant donne qu’il est l’objet d’une doxographie certes riche mais qui peut etre analysee dans son integralite. De plus, elle nous offre un eclairage sur la place de l’eleatisme dans l’histoire de la pensee. Nous avons propose pour chaque temoin une analyse de leur interpretation de Melissos, mais nous sommes concentressur trois grandes lectures : celle d’Aristote, de Pseudo-Aristote dans le MXG et la reinterpretation neoplatonicienne par Philopon et Simplicius. Notre edition presente la quasi-integralite des textes anciens qui mentionnent Melissos, et est accompagnee d’un apparat critique selectif compose a partir des editions deja existantes, mais modifie en fonction de nos propres choix editoriaux. Elle est accompagnee d’une traduction annotee en francais.
Clinical reasoning difficulties: A taxonomy for clinical teachers

Background: Clinical reasoning is the cornerstone of medical practice. To date, there is no established framework regarding clinical reasoning difficulties, how to identify them, and how to remediate them. Aim: To identify the most common clinical reasoning difficulties as they present in residents’ patient encounters, case summaries, or medical notes. To develop a guide to support medical educators’ process of educational diagnosis and management in this area. Methods: We used a participatory action research method. We carried out eight iterative reflective cycles with a group of clinical teachers. The repeated phases of experimentation and observation were conducted by participants in their own clinical teaching setting. Our findings were tested and validated on both an individual and collective basis Results: We found five categories of clinical reasoning difficulties as they present in the clinical teaching settings. We identified indicators for each. Indicators may be different depending on the type of supervision. These findings were assembled and organized to construct a guide for clinical teachers. Conclusions: The guide should assist clinical teachers in detecting clinical reasoning difficulties during clinical teaching and in providing remediation that is tailored to the specific difficulty identified. Its development furthers our understanding of clinical reasoning difficulties and provides a useful tool.
Using the Phenogen website for
 ‘in silico’ analysis of morphine‐induced analgesia: identifying candidate genes

The identification of genes that contribute to polygenic (complex) behavioral phenotypes is a key goal of current genetic research. One approach to this goal is to combine gene expression information with genetic information, i.e. to map chromosomal regions that regulate gene expression levels. This approach has been termed ‘genetical genomics’, and, when used in conjunction with the identification of genomic regions (QTLs) that regulate the complex physiological trait under investigation, provides a strong basis for candidate gene discovery. In this paper, we describe the implementation of the genetical genomic/phenotypic approach to identify candidate genes for sensitivity to the analgesic effect of morphine in BXD recombinant inbred mice. Our analysis was performed ‘in silico’, using an online interactive resource called PhenoGen (http://phenogen.ucdenver.edu). We describe in detail the use of this resource, which identified a set of candidate genes, some of whose products regulate the cellular localization and activity of the mu opiate receptor. The results demonstrate how PhenoGen can be used to identify a novel set of genes that can be further investigated for their potential role in pain, morphine analgesia and/or morphine tolerance.
Performance Analysis of Linear Receivers for Uplink Massive MIMO FBMC-OQAM Systems

Offset-quadratic-amplitude-modulation-based filterbank multicarrier (FBMC-OQAM) has been shown to be a promising alternative to cyclic prefix-orthogonal frequency division multiplexing. More recently, the use of FBMC-OQAM has been proposed in combination with massive MIMO communications. In this context, it is interesting to study the overall effect of massive MIMO on the FBMC-OQAM intrinsic interference and its interaction with channel frequency selectivity. In this paper, the performance of an FBMC-OQAM uplink massive MIMO system is theoretically characterized in terms of the output mean squared error (MSE) of the estimated transmitted symbols and for three types of linear receivers, namely, zero forcer, linear minimum mean squared error, and matched filter. Using random matrix theory, the output MSE of these receivers is asymptotically characterized as the number of base station antennas <inline-formula> <tex-math notation="LaTeX">$N$</tex-math></inline-formula> and the number of users <inline-formula> <tex-math notation="LaTeX">$K$</tex-math></inline-formula> grow large, while keeping a finite ratio <inline-formula> <tex-math notation="LaTeX">$N/K$</tex-math></inline-formula>. The obtained expressions allow to draw many conclusions, some of which were already noticed in the literature but not yet theoretically proven. First, the MSE becomes uniform across the frequency band as a result of the channel hardening effect. Second, it is shown that a good synchronization of the users is crucial in a massive MIMO scenario. Finally, if the users are well synchronized, the different terms that compose the MSE, such as noise, interuser interference, and the distortion caused by the channel frequency selectivity, become negligible for large values of the ratio <inline-formula><tex-math notation="LaTeX">$N/K$ </tex-math></inline-formula>. This effect was previously referred to as “self-equalization” in the literature.
Measurement of peak inhalation rates with an in-check meter to identify an elderly patient's ability to use a turbuhaler.

Dry powder inhalers are designed with resistance to airflow so that a respirable cloud of particles is generated during inhalation. Some of these devices require a certain inhalation rate to produce a consistent dose of respirable particles. The aim of the study was to determine the inhalation rate of elderly patients with chronic obstructive pulmonary disease (COPD) when they inhale through a Turbuhaler and assess the potential of the In-Check Meter to identify inhalation rates. Their peak inhalation rate using a normal inhalation, pre- and post-counselling, was measured using a Turbuhaler Trainer and an In-Check Meter. Spirometry was also measured. Seventy-four COPD patients with a mean (SD) age of 79.7 (8.4) years and forced expiratory volume in 1 sec (FEV1) 41.9 (12.8)% predicted. Pre-counselling 14 obtained a rate of <30 l min(-1) with the Turbuhaler Trainer, 31 from 30 to 40 min(-1), 23 between 40-60 l min(-1) and 6 > 60 l min(-1). The median (range) peak inhalation rates with the In-Check Meter were 50 (50-70), 70 (50-130), 100 (60-200) and 225 (200-250) l min(-1). Post-counselling 7, 16,41 and 10 achieved the respective peak inhalation rates using the Turbuhaler Trainer Similarly the In-Check inhalation rates were 50 (50-60), 70 (50-130), 90 (60-200) and 250 (200-270) l min(-1). The results highlight the potential of the In-Check Meter to identify patients' inhalation rates through dry powder inhalers.
Herpes simplex virus type 1 ICP27 is an essential regulatory protein

The five immediate-early genes of herpes simplex virus are expressed during the initial stages of the infectious cycle, and certain immediate-early proteins have been shown to play a regulatory role in subsequent viral gene expression. Until recently, the functional properties of only one immediate-early protein, ICP4, had been examined in any detail, primarily because mutants had been isolated only in the gene for ICP4. We report herein the genetic and phenotypic characterization of four temperature-sensitive mutants of herpes simplex virus type 1 (tsY46, tsE5, tsE6, and tsLG4) that have begun to elucidate the function(s) of a second immediate-early protein, ICP27. The four mutants complemented each other inefficiently or not at all, indicating that they are defective in the same function. Marker rescue tests placed the mutations in tsY46 and tsE5 in sequences that encode the transcript for ICP27; the mutations in tsE6 and tsLG4 lie in or near these sequences. The ability of wild-type ICP27 expressed from a cloned gene to complement tsY46 and tsLG4 constitutes additional evidence that these mutants are defective in an ICP27-associated function. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of mutant-infected cell polypeptides showed that certain immediate-early (alpha) polypeptides were overproduced, whereas significant levels of early (beta) and drastically reduced levels of several late (gamma) proteins were synthesized at the nonpermissive temperature. Interestingly, the mutants were observed to form a spectrum with regard to their relative abilities to induce the expression of a number of polypeptides, especially those of the delayed-early (beta gamma) class. Consistent with their ability to induce expression of early polypeptides, all of the mutants induced the synthesis of substantial levels of viral DNA at the nonpermissive temperature. Taken together, the results of these studies demonstrate that ICP27 plays an essential regulatory function in virus replication, that this function is required after the onset of early gene expression and viral DNA synthesis, and that the inability of the mutants to induce the synthesis of late proteins is independent of viral DNA synthesis.
The Ubiquitin-Proteasome System Facilitates the Transfer of Murine Coronavirus from Endosome to Cytoplasm during Virus Entry

ABSTRACT The ubiquitin-proteasome system is involved in cellular endocytosis and maturation of some viruses. In this study, we found that proteasome inhibitors blocked mouse hepatitis virus replication at an early step in the viral life cycle. In the presence of MG132, the entering viruses accumulated in both the endosome and denser lysosome, suggesting that the ubiquitin-proteasome system is involved in the release of virus from the endosome to the cytosol during the virus entry step.
DNS and modeling of the interaction between turbulent premixed flames and walls

The interaction between turbulent premixed flames and walls is studied using a two-dimensional full Navier-Stokes solver with simple chemistry. The effects of wall distance on the local and global flame structure are investigated. Quenching distances and maximum wall heat fluxes during quenching are computed in laminar cases and are found to be comparable to experimental and analytical results. For turbulent cases, it is shown that quenching distances and maximum heat fluxes remain of the same order as for laminar flames. Based on simulation results, a 'law-of-the-wall' model is derived to describe the interaction between a turbulent premixed flame and a wall. This model is constructed to provide reasonable behavior of flame surface density near a wall under the assumption that flame-wall interaction takes place at scales smaller than the computational mesh. It can be implemented in conjunction with any of several recent flamelet models based on a modeled surface density equation, with no additional constraints on mesh size or time step.
Lossless image compression using valley transform

In this paper, a novel geometric transform, called the valley transform (VT), is proposed for robust compression of noisy images. The VT employs a nonlinear transform to convert random signals into regular ones. The proposed VT is able to change random pixels to regular one. For testing the compression performance, the VT is combined with the SPHIT method. The VT yields slightly better performance than the conventional image codecs such as JBIG, HD-photo and H.264 intra method in the lower bit-plane image compression.
Statistical Machine Translation Adding Rule-based Machine Translation

We have developed a two-stage machine translation (MT) system. The first stage is a rule-based machine translation system. The second stage is a normal statistical machine translation system. For Japanese-English machine translation, first, we used a JapaneseEnglish rule-based MT, and we obtained "ENGLISH" sentences from Japanese sentences. Second, we used a standard statistical machine translation. This means that we translated "ENGLISH" to English machine translation. We believe this method has two advantages. One is that there are fewer unknown words. The other is that it produces structured or grammatically correct sentences. From the results of experiments, we obtained a BLEU score of 0.2565 in the Intrinsic-JE task using our proposed method. In contrast, we obtained a BLEU score of 0.2165 in the Intrinsic-JE task using a standard method (moses). And we obtained a BLEU score of 0.2602 in the Intrinsic-EJ task using our proposed method. In contrast, we obtained a BLEU score of 0.2501 in the Intrinsic-EJ task using a standard method (moses). This means that our proposed method was effective for the IntrinsicJE and Intrinsic-EJ task. For the future study, we will try to improve the performance by optimizing parameters.
Complex determinants of macrophage tropism in env of simian immunodeficiency virus

Macrophage-tropic virus variants evolved during the course of infection of individual rhesus monkeys with cloned, non-macrophagetropic simian immunodeficiency virus. Specific changes in the envelope gene (env) were found to be primarily responsible for the dramatic increase in the ability of the virus to replicate in macrophages. Cloned viruses differing at nine amino acid positions in env exhibited a more than 100-fold difference in replicative capacity for primary cultures of rhesus monkey alveolar macrophages. At least five of the nine amino acid changes contributed to macrophage tropism. These determinants were distributed across the full length of env, including both the gp120 and gp41 products of the env gene. Furthermore, the emergence of macrophagetropic variants in vivo was associated with specific pathologic manifestations in which the macrophage is the major infected cell type. Thus, major determinants of macrophage tropism reside in env, they can be complex in nature, and the presence of macrophage-tropic virus variants in vivo can influence the disease course and disease manifestations.
Dynamic and adaptive detection method for flooding in wireless sensor networks

In recent years, wireless sensor networks (WSNs) have attracted an increasing attention in several fields. However, WSNs must be treated with significant challenges in their design due to their special characteristics such as limited energy, processing power, and data storage that make the energy consumption saving a real challenge. Also, regarding their distributed deployment in open radio frequency and lack of physical security, these networks are vulnerable and exposed to several attacks: passive eavesdropping, active attacks, and identity theft. In this paper, we propose a new method called accordion method to detect and apprehend denial of service attacks in WSNs. This approach is a dynamic and an adaptive method based on using clustering method which allows electing control nodes that analyze the traffic inside a cluster and send warnings to the cluster head whenever an abnormal behavior is suspected or detected. The proposed method relies on the analysis of the evolution of the threshold messages (alerts) sent in the cluster. The proposed method has been evaluated, and the obtained numerical results show its benefit compared with other detection methods.
88-$\mu$ A 1-MHz Stray-Insensitive CMOS Current-Mode Interface IC for Differential Capacitive Sensors

The paper describes an innovative technique to implement a low-power high-speed CMOS interface circuit for differential capacitive sensors. The proposed approach comprises a capacitance to current converter providing current-summing and current-differencing capability. It also exploits an autotuning feedback loop to control the common-mode current, thereby ensuring virtually the same maximum sensitivity and measure accuracy irrespectively of the input parasitic capacitance. Therefore, the main limitation of all previous current-mode techniques is nearly eliminated. Besides, as an additional distinctive aspect, the proposed solution is suitable for both linear- and hyperbolic-type capacitive sensors. To validate the idea an interface circuit was designed in a 65-nm CMOS technology powered from a 2.5-V supply and dissipating 88- μA standby current. Measurements show that relative capacitive sensor variations up to ± 900 fF ( ± 100% of the nominal value) even in presence of a large parasitic capacitance of 2.5 pF are detected in less than 1 μs with a sensitivity of about 5 nA/fF and with an relative error lower than ± 1.5%, without requiring digital calibration.
Differential Incorporation of Cholesterol by Sindbis Virus Grown in Mammalian or Insect Cells

ABSTRACT Cholesterol has been shown to be essential for the fusion of alphaviruses with artificial membranes (liposomes). Cholesterol has also been implicated as playing an essential and critical role in the processes of entry and egress of alphaviruses in living cells. Paradoxically, insects, the alternate host for alphaviruses, are cholesterol auxotrophs and contain very low levels of this sterol. To further evaluate the role of cholesterol in the life cycle of alphaviruses, the cholesterol levels of the alphavirus Sindbis produced from three different mosquito (Aedes albopictus) cell lines; one other insect cell line, Sf21 from Spodoptera frugiperda; and BHK (mammalian) cells were measured. Sindbis virus was grown in insect cells under normal culture conditions and in cells depleted of cholesterol by growth in serum delipidated by using Cab-O-sil, medium treated with methyl-β-cyclodextrin, or serum-free medium. The levels of cholesterol incorporated into the membranes of the cells and into the virus produced from these cells were determined. Virus produced from these treated and untreated cells was compared to virus grown in BHK cells under standard conditions. The ability of insect cells to produce Sindbis virus after delipidation was found to be highly cell specific and not dependent on the level of cholesterol in the cell membrane. A very low level of cholesterol was required for the generation of wild-type levels of infectious Sindbis virus from delipidated cells. The data show that one role of the virus membrane is structural, providing the stability required for infectivity that may not be provided by the delipidated membranes in some cells. These data show that the amount of cholesterol in the host cell membrane in and of itself has no effect on the process of virus assembly or on the ability of virus to infect cells. Rather, these data suggest that the cholesterol dependence reported for infectivity and assembly of Sindbis virus is a reflection of differences in the insect cell lines used and the methods of delipidation.