Miracle-dz/UniFAR-FTUs huggingface dataset:
Pain Assessment with Cognitively Impaired Older People in the Acute Hospital Setting

• Research reveals that older people continue to experience much suffering from acute and chronic pain conditions. • People with cognitive impairment receive less analgesia than their cognitively intact peers. • Postoperative pain assessment with older people in the acute hospital setting remains a challenge. • Context and culture have a significant impact of pain assessment practices. • Due to a paucity of research exploring how pain assessment and management practices with cognitively impaired older people may be realised in the acute hospital setting, there is a need for further research to be conducted.
Tentative governance for new markets by creating market infrastructures

Section 1. Setting the issue This paper explores the conditions under which radical innovations find their way into society. It more specifically focuses on the multiplicity of strategies that actors deploy to structure future markets for their innovations. We could talk of tentative governance work. In the classical view, the “innovation journey” (Van de Ven et al. , 1999) comprises two main phases, a fluid one focused on exploration (March, 1991), and a retention one focused on exploitation and organized around a dominant design (Abernathy and Clark, 1985; Tushman and Anderson, 1986) which facilitates cumulative evolutions that generalize its use. Much work has been done on how exploration is nurtured, which has been well synthesized by Rip and Kemp (1998) in their notion of “protected spaces”. These authors highlight the
Validation and Reproducibility of Measurement of 5-HT1A Receptor Parameters with [carbonyl-11C]WAY-100635 in Humans: Comparison of Arterial and Reference Tissue Input Functions

Serotonin 5-HT1A receptors are implicated in the pathophysiology of neuropsychiatric conditions. The goal of this study was to evaluate methods to derive 5-HT1A receptor parameters in the human brain with positron emission tomography (PET) and [carbonyl-11C]WAY 100635. Five healthy volunteer subjects were studied twice. Three methods of analysis were used to derive the binding potential (BP), and the specific to nonspecific equilibrium partition coefficient (k3/k4). Two methods, kinetic analysis based on a three compartment model and graphical analysis, used the arterial plasma time-activity curves as the input function to derive BP and k3/k4. A third method, the simplified reference tissue model (SRTM), derived the input function from uptake data of a region of reference, the cerebellum, and provided only k3/k4. All methods provided estimates of regional 5-HT1A receptor parameters that were highly correlated. Results were consistent with the known distribution of 5-HT1A receptors in the human brain. Compared with kinetic BP, graphical analysis slightly underestimated BP, and this phenomenon was mostly apparent in small size-high noise regions. Compared with kinetic k3/k4, the reference tissue method underestimated k3/k4 and the underestimation was apparent primarily in regions with high receptor density. Derivation of BP by both kinetic and graphical analysis was highly reliable, with an intraclass correlation coefficient (ICC) of 0.84 ± 0.14 (mean ± SD of 15 regions) and 0.84 ± 0.19, respectively. In contrast, the reliability of k3/k4 was lower, with ICC of 0.53 ± 0.28, 0.47 ± 0.28, and 0.55 ± 0.29 for kinetic, graphical, and reference tissue methods, respectively. In conclusion, derivation of BP by kinetic analysis using the arterial plasma input function appeared as the method of choice because of its higher test—retest reproducibility, lower vulnerability to experimental noise, and absence of bias.
Optimal Control and Simulation of Brushed Direct-Current Motor Stability Program

In this study, a principal model of a brushed direct-current (DC) motor that has become a benchmark is described. Then it stability program was designed based on linear quadratic optimal control theory and the controllability and observability were studied. Choosing brushed DC motor output angle θ as control variables. Simulation on this control system in Matlab/Simulink software environment was described It has been observed that the controller stabilizes the system. In addition, computer simulations show the effectiveness of the proposed approach. Parameterization of matrices, calculation of optional controller and simulations are done by using Matlab/Simulink programming.
Noninvasive tests as a substitute for histology in the diagnosis of Helicobacter pylori infection.

BACKGROUND Rapid urease tests for Helicobacter pylori have a sensitivity of 80% to 90%. Therefore histologic examination of gastric biopsies is recommended as a "backup" diagnostic test in rapid urease test-negative patients. However, noninvasive tests (urea breath test, serology, whole blood antibody tests) may provide a more rapid diagnosis and be less expensive but offer similar accuracy. METHODS Sixty-seven patients (no prior treatment for H pylori, no proton pump inhibitors, antibiotics, or bismuth within 4 weeks) undergoing endoscopy for evaluation of dyspepsia symptoms and testing rapid urease test-negative by antral biopsy were enrolled. All had the following tests: gastric biopsies (2 antral, 1 fundus; H&E and Alcian Yellow stain) examined for gastritis and H pylori; (13)C-UBT; capillary blood for whole blood rapid antibody tests: FlexSure HP, QuickVue, AccuStat, and Stat-Simple Pylori; serum for FlexSure HP; HM-CAP enzyme-linked immunoassay. H pylori infection was diagnosed (reference standard) if chronic gastritis was present on histology and at least 2 of the 3 following tests were positive: urea breath test, H pylori organisms unequivocally demonstrated in biopsies on special stain, and/or enzyme-linked immunoassay. The test and treatment costs per patient were calculated. RESULTS Of 67 patients with a negative rapid urease test, 4 were positive for H pylori. None had active peptic ulcer disease. Histology only identified 1 patient with organisms visible on special stain. Using chronic active gastritis (neutrophilic and mononuclear infiltrate) as a diagnostic criterion for H pylori, 6 patients would have been judged positive. However, only 2 of these were truly positive by the reference standard (positive predictive value 33%). Negative predictive value for presence of organisms and chronic active gastritis was 95% and 97%, respectively. All of the noninvasive tests identified all 4 truly positive patients correctly. Urea breath test and FlexSure whole blood assay yielded a substantial number of false-positive results (positive predictive value 31% and 36%, respectively); positive predictive value for the other tests ranged from 50% to 80%. All tests except histology had a negative predictive value of 100%. Histology was the most costly test (p < 0. 001 compared with all other tests), followed by urea breath test and HM-CAP serology (p < 0.001 compared with all rapid antibody tests). CONCLUSIONS Whole blood or serum antibody testing is a rapid, accurate, and cost-effective means for establishing H pylori status in rapid urease test-negative patients. Whole blood or serology rapid antibody testing should substitute for histology when the patient has not been previously treated for H pylori.
Prediction Of Customer Churn In Mobile Industry Using Probablistic Classifiers.

A B S T R A C T Customer churn prediction in Mobile industry is a latest research topic in recent years. A huge amount of data is generated in Mobile industry every minute. Data mining techniques have also developed in various ways. Customer churn is considered as one of the major issues in Mobile industry. The research signifies that it is more expensive to gain a new customer than to retain an existing one. The knowledge extracted from Mobile industry helps to understand the reasons of customer churn and Telecom providers use the data to retain existing customers. This paper surveys the commonly used data mining techniques to identify customer churn patterns. Classification and association models are the two most commonly used models for data mining in Customer Relationship Management. This study focuses on data mining techniques for reducing customer churn and also likely to reduce error ratio. The recent literature in the area of predictive data mining techniques in customer churn behaviour is reviewed and a discussion on the future research directions is offered . Index Terms: Customer churn, Customer retention, Customer relationship management (CRM), Data mining, C4.5, Naive Bayes classifier.
Cosputtered Cu/Ti Bonded Interconnects With a Self-Formed Adhesion Layer for Three-Dimensional Integration Applications

A novel 3-D bonding technology with cosputtered copper and titanium as bonding material is proposed and investigated based on the diffusion mechanism of cosputtered metal during bonding. This technology features a self-formed adhesion layer for Cu metal layers and interconnects. In addition, cosputtered Cu/Ti bonding exhibits good electrical performance as well as high resistance to multiple current stressing. With the advantages of fabrication efficiency and reliable bond quality, cosputtered Cu/Ti bonding technology presents the potential to be applied in 3-D integration.
Endovascular treatment of wide-necked intracranial aneurysms : techniques and outcomes in 15 patients.

OBJECTIVE It is technically difficult to treat wide-necked intracranial aneurysms by the endovascular method. Various tools and techniques have been introduced to overcome the related technical limitations. The purpose of this study was to evaluate the radiologic and clinical results of wide-necked intracranial aneurysm treatment using the endovascular method. METHODS Fifteen aneurysms in 15 patients were treated by the endovascular method from October 2009 to August 2010. Seven patients presented with subarachnoid hemorrhage (SAH), seven patients had unruptured aneurysms, and one patient had an intracerebral hemorrhage and intraventricular hemorrhage due to an incompletely clipped aneurysm. The mean dome-to-neck ratio was 1.1 (range, 0.6-1.7) and the mean height-to-neck ratio was 1.1 (range, 0.6-2.0). We used double microcatheters instead of a stent or a balloon for the first trial. When we failed to make a stable coil frame with two coils, we used a stent-assisted technique. RESULTS All aneurysms were successfully embolized. Eleven aneurysms (73%) were embolized by the double microcatheter technique without stent insertion, and four aneurysms (27%) were treated by stent-assisted coil embolization. One case had subclinical procedure-related intraoperative hemorrhage. Another case had procedure-related thromboembolism in the left distal anterior cerebral artery. During the follow-up period, one patient (7%) had a recanalized aneurysmal neck 12 months after coil embolization. The recurrent aneurysm was treated by stent-assisted coil embolization. CONCLUSION We successfully treated 15 wide-necked intracranial aneurysms by the endovascular method. More clinical data with longer follow-up periods are needed to establish the use of endovascular treatment for wide-necked aneurysm.
A Comparison of Management Systems for Development Co-Operation in OECD/DAC Members

The Members of the Development Assistance Committee (DAC) of the OECD have set an ambitious and specific target: reduce by one half the proportion of people living in extreme poverty by 2015. The aid management systems of DAC Members represent key elements in the basic architecture for attaining that goal. A Comparison of Management Systems for Development Co-operation in OECD/DAC Members provides a panaroma of aid management systems of DAC Members. It describes, analyses and compares those systems and provides specific examples. In addition, it presents the main themes of reflection within the DAC with key policy statements.
Cognitive and Behavioral Functioning of Children Listed for Heart and/or Lung Transplantation

The objective of the study was to assess cognitive function and behavior in a group of children listed for heart and/or lung transplantation. Ninety‐nine children (3.7–16.8 years) listed for heart and/or lung transplant for congenital heart disease (CHD), cardiomyopathy (CM), cystic fibrosis (CF) or primary pulmonary hypertension (PPH) were evaluated with standardized measures of cognitive function, academic ability and behavior. Results were compared with a historical cohort of healthy children and comparisons were made between the four diagnostic subgroups. Mean subtest scores, overall IQ and achievement scores were within the normal range for the total group but were significantly lower than those of the healthy group. Although there were few significant differences between the diagnostic subgroups children with CHD or CF tended to perform at a lower level than those with CM or PPH. There were some significant issues with behavior for all diagnostic subgroups, particularly in the domain of social competence. Patients with end‐stage heart or lung disease are at increased risk for cognitive and/or behavioral problems, particularly those with CHD. Follow‐up of these patients after transplant is important to determine the role that psychological functioning prior to surgery has in the longer term after surgery.
Health Service Gatekeepers

Incentive contracts for gatekeepers who control patient access to specialist medical services provide too weak incentives to investigate cost further when expected cost of treatment is greater than benefit. Making gatekeepers residual claimants with a fixed fee from which treatment costs must be met (as with full insurers who are themselves gatekeepers) provides too strong incentives when expected cost is less than benefit. Giving patients the choice between a gatekeeper with an incentive contract and one without is unstable. With one scenario, patients always prefer the latter. With another, patients have incentives to acquire information that makes incentive contracts ineffective.
Ultraviolet Radiation-Induced Corneal Degeneration in 129 Mice

Ultraviolet radiation (UVR) is a risk factor for the development of ocular disease in humans, including acute photokeratitis, chronic corneal spheroidal degeneration, and cataract formation. This report describes the ocular lesions seen in 21 mice chronically exposed to UVR as part of a skin carcinogenicity study. All globes were affected to varying degrees. The primary lesion, not previously reported in UVR-exposed mice, was marked loss of keratocytes relative to age-matched controls. Secondary lesions included corneal stromal thinning, keratoconus, corneal vascularization and fibrosis, keratitis, globe rupture, and phthisis bulbi. In addition, more than 90% of UVR-exposed and unexposed lenses had evidence of cataract formation; this is the first report of the occurrence of spontaneous cataracts in 129 mice. In a subsequent study, apoptotic cells were identified histologically and by cleaved caspase 3 immunoreactivity in the corneal epithelium and, less commonly, in the corneal stroma after acute UVR exposure. Based on this finding, we propose that the loss of keratocytes observed in the chronic study was due to UVR-induced apoptosis.
Reinhard's global operator based inverse tone mapping with one parameter

This paper proposes a new inverse tone mapping operator (TMO) with only one parameter. The proposed inverse TMO is based on Reinhard's global operator which is a well-known TMO. Inverse TM operations have two applications: generating an HDR image from an existing LDR one, and reconstructing an original HDR image from the mapped LDR image. In this paper, we focus on the latter application and the proposed method can produce an HDR image that has high image quality. In the latter application, two parameters used in Reinhard's TMO, i.e. the key value α regarding brightness of a mapped LDR one and the geometric mean Lw of an original HDR one, are generally required for carrying out the Reinhard based inverse_TMO. In this paper, we show that it is possible to estimate Lw from α under some conditions, so that a new inverse TMO with one parameter is proposed. Experimental results show that the proposed method outperforms conventional ones for the latter application, in terms of high image quality and low computing cost.
Outbreak of KPC-3-producing ST15 and ST348 Klebsiella pneumoniae in a Portuguese hospital

SUMMARY To date, only a few sporadic cases of infections due to Klebsiella pneumoniae carbapenemase (KPC) producers have been reported in Portugal. Here, we report for the first time an outbreak of K. pneumoniae KPC-3 producers in a tertiary-care hospital during 2013. Twenty-seven ertapenem-resistant K. pneumoniae were identified in patients at a tertiary-care hospital during 2013 isolated predominantly from urine (48·1%) and blood (25·9%) cultures. All isolates were highly resistant to β-lactam antibiotics and most showed intermediate resistance to imipenem. The more frequent β-lactamases were TEM- (77·7%), CTX-M- (70·3%) and KPC-type (66·6%). KPC-3 was identified by sequencing. The bla KPC−3 gene was associated with an IncF plasmid, and efficiently transferred to E. coli J53. Pulsed-field gel electrophoresis typing revealed three clusters of isolates which were further characterized by multi-locus sequence typing as ST11, ST15 and ST348. Ertapenem-resistant ST15 was already in circulation in the hospital, related to expression of OmpK36 modified porin, but the other two sequence types had not been previously found in the hospital. We conclude that the IncF plasmid mediated transfer of KPC-3 in the outbreak and that implementation of carbapenemase gene screening in isolates from patients on admission to hospital is advisable in order to control dissemination of these antimicrobial resistance elements.
Multiuser Wireless communication Using OFDM System

In this paper, we study the multiuser orthogonal frequency division multiplexing (OFDM) downlink systems with simultaneous wireless information and power transfer for resource allocation algorithm design. The algorithm design for maximizing the energy efficiency of data transmission (bit/Joule delivered to the users) is formulated. We study the design for simultaneous wireless information and power transfer (SWIPT) in downlink multiuser orthogonal frequency division multiplexing (OFDM) systems, where from a fixed access point (AP) the user harvest energy and decode information using the same received signals. we consider orthogonal frequency division multiple access (OFDMA) scheme for information transmission. Due to the practical limitation at receiver side each user apply power splitting (PS) to coordinate the energy harvesting (EH) and information decoding (ID) processes. The main purpose of this paper is to use the MATLAB Simulink of OFDM to analyse the energy harvesting and information decoding processes. Simulation results show that the proposed iterative resource allocation algorithm achieves the maximum energy efficiency of the system and show how system capacity, energy efficiency and wireless power transfer benefit from the presence of multiple users in the system.
Virtual Community

Abstract While previous marketing activities were primarily focused on increasing market shares in terms of a mass marketing based on single transactions, the past few years saw a paradigmatic shift towards relationship management. In this respect, virtual communities are becoming increasingly significant for online customer relationship management. A major aspect of virtual communities is the concept of social capital. It will be shown that virtual communities that provide social capital are a key instrument to establish satisfaction, trust, and commitment within a business relationship.
Torque ripple minimization for switched reluctance motor with predictive current control method

In order to reduce the torque ripple and improve the torque-speed characteristic of switched reluctance motor, a novel predictive current control method is proposed in this paper. Compared with conventional current hysteresis control, the current tracing ability is improved by using proposed method without increasing switch frequency or changing hysteresis band. Both of torque ripples and copper loss reduction of different TSFs are investigated respectively. Experiments with 5.5kw three-phase 12/8 SRM verify the effectiveness of the proposed control strategies.
Prostanoid Receptors of Murine NIH 3T3 and RAW 264.7 Cells

Prostaglandin endoperoxide H synthase-1 (PGHS-1) is expressed constitutively in murine NIH 3T3 cells and RAW 264.7 cells. PGHS-2 is inducibly expressed in these cells following stimulation with serum or bacterial lipopolysaccharide (LPS), respectively. Reverse transcription-polymerase chain reaction (RT-PCR) analysis established that a variety of G protein-linked and peroxisomal proliferator-activated prostanoid receptors are expressed in both of these cell types. The levels of the EP2 and EP4 prostaglandin E2 (PGE2) receptors and the prostaglandin I2 receptor were changed in these cells by serum or LPS stimulation. Quantitative RT-PCR indicated that the mRNA for the murine EP4 receptor, the butaprost-insensitive PGE2 receptor that couples to Gs, increases 1.5-3-fold in response to serum (NIH 3T3) or LPS (RAW 264.7) with a time course approximating the induction of PGHS-2 expression. To study expression of the EP4 receptor we isolated the mouse EP4 receptor gene; the gene is 10 kilobase pairs (kb) in length and, like other known prostanoid receptor genes, contains three exons and two introns. The first intron is 0.5 kb and is located 16 base pairs (bp) downstream of the translational start site. This is a different location than that of the first introns of other prostanoid receptor genes. The second intron is located immediately following the sixth transmembrane domain at the same position as the second intron of the thromboxane A2 receptor, prostaglandin D2 receptor, prostaglandin I2 receptor, and one of the PGE2 (EP1) receptor genes. A major transcriptional start was detected at −142 bp upstream of the translational start. There are a variety of putative cis-acting elements within 1.5 kb upstream of the translational start site and within the first intron. Promoter analyses of the EP4 receptor gene promoter in RAW 264.7 cells indicated that there is a constitutive negative regulatory region between −992 and −928 bp, a constitutive positive region between −928 and −554 bp, and an LPS/serum-responsive region between −554 and −116 bp.
Estimation of Vocal Duration in Monaural Mixtures

In this study, the task of vocal duration estimation in monaural music mixtures is explored. We show how presently available algorithms for source separation and predominant f0 estimation can be used as a front end from which features can be extracted. A large set of features is presented, devised to connect different vocal cues to the presence of vocals. Two main cues are utilized; the voice is neither stable in pitch nor in timbre. We evaluate the performance of the model by estimating the length of the vocal regions of the mixtures. To facilitate this, a new set of annotations to a widely adopted data set is developed and made available to the community. The proposed model is able to explain about 78 % of the variance in vocal region length. In a classification task, where the excerpts are classified as either vocal or non-vocal, the model has an accuracy of about 0.94.
CEO Power and Corporate Social Responsibility (CSR)

Hong, Li, Minor (2015) paper studied that agency cost perspective of Corporate Social Responsibility (CSR) and concluded CSR activities are beneficial to both firm and shareholders. And there is existence of Executive compensation contract has incentive for CSR. But does CSR provide incentive for CEO? If it does, then more power the CEO of the firm has, the more likelihood the CSR will contain in executive compensation contract. With consideration of Endogeneity problem, we found that there is strong evidence support our hypothesis which concludes our findings that CSR provide incentive to CEO.