Miracle-dz/UniFAR-FTUs huggingface dataset:
A new path planner based on flatness approach application to an atmospheric reentry mission

This communication proposes a method for designing a model-based onboard path planner for next generation reusable launch vehicles. Flatness approach is used to map the system dynamics into a lower dimension space. As a consequence, the number of optimization variables associated to the optimal control problem is reduced. In addition, nonconvex nonlinear trajectory constraints in the flat output space are inner approximated by means of deformable geometric shapes. A genetic algorithm is used to find a global solution both for the geometric shapes and the associated geometric transformations tuning parameters. Finally, simulations results, based on the terminal area energy management phase of the Shuttle orbiter STS-1 reentry mission, are presented to illustrate the proposed approach.
Clinical and microbiologic effects of chemical versus mechanical cleansing in professional supportive implant therapy.

The aim of the present study was to compare the cleansing properties of mechanical supportive care for dental implants with the use of an etching gel. Sixteen patients underwent a 5-month clinical trial with monthly recalls. These patients, wearing maxillary complete dentures and mandibular overdentures supported by a bar device on 4 implants, were treated in a split-mouth study design. Test and control therapy were randomly assigned to left and right sides of the mandible. At the test side, 35% phosphoric etching gel (pH 1) was applied in the peri-implant sulcus. After 1 minute, the sulcus was thoroughly rinsed with a water spray for approximately 15 seconds per implants. Control therapy consisted of supra- and subgingival debridement using carbon fiber curettes and a rubber cup. Plaque, calculus, probing pocket depth, and modified Gingival Index were determined before each treatment. Microbiologic evaluation was performed at baseline, 1 month later, and 5 months later, just before and immediately after each treatment. Per treatment and per assessment, the mean scores of all clinical parameters were calculated for each patient. The number of colony-forming units was used as the primary efficacy variable in the analysis of microbiologic data. At baseline, no differences between test and control sites were observed for any of the clinical parameters. The mean Gingival Index and the mean probing pocket depth were reduced over the 5-month period. The mean reduction in Gingival Index at the test sites proved to be significantly larger at the control sites (P = .03). Both treatment modalities resulted in an instant reduction of the number of colony-forming units, where the reduction by chemical cleaning was larger (P < .05). This short-term study employing a high recall frequency indicates that local application of 35% phosphoric acid gel can be as effective as conventional mechanical supportive therapy.
Backpropagation through Time for Learning of Interconnected Neural Networks -- Identification of Complex Systems

Neural networks are mainly employed to model complex systems behavior. This work aims at broadening area of their applications to input-output dynamic complex systems of cascade structure. Each element of the complex system is modeled by a multi-input, multi-output recurrent neural network. A model of the whole system is obtained by composing all neural networks into one global network. Main contribution of this work is generalization of back propagation through time method to complex systems modeled by interconnected neural networks. Appropriate algorithm is provided and numerical simulations are performed.
Prehypertension and obesity in middle-aged Korean men and women: the third Korea national health and nutrition examination survey (KNHANES III) study.

BACKGROUND The aim of this study was to investigate the association between obesity and prehypertension (preHT) after adjustment for socioeconomic position and health behavior factors. METHODS The study sample included 1973 Korean men and women, 45-64 years of age. Subjects were classified into three groups based on their baseline blood pressure: prehypertensive, hypertensive and normotensive. Men with a waist circumference ≥90 cm or women ≥80 cm were considered abdominally obese. Body mass index (BMI) obesity was defined as having a BMI ≥25. The prevalence of abdominal obesity and BMI obesity was calculated with age adjustment using a direct method. Multinomial logistic regression analysis was applied. RESULTS The prevalence of preHT in our study was 52.8%. We found that subjects with abdominal obesity were 2.06 times as likely to be prehypertensive as those without it and people with BMI obesity were 1.89 times as likely to be prehypertensive as those without it. Interestingly, men with BMI obesity had a higher preHT risk, while women with abdominal obesity had a higher preHT risk. CONCLUSIONS Statistical analyses of a community-based random sample of the Korean population indicate that obesity is associated with preHT in Korean middle-aged subjects.
The relation between Greek and Islamic materia medica.

Many studies have been made on the exact data of the introduction of Greek sciences to the Arabic culture. During the 8th and 9th centuries A.D. a big progress was done in the Arab-Islamic sciences, when the Caliphs of the Omayad and Abbasid dynasties invited many scientists, researchers and translators for translation of all sciences into Arabic. The Arabs paid special attention to the Greek natural sciences such as botany and pharmacy. Greek materia medica was a major common basis for Arab-Islamic medicine and pharmacy which in turn paved the way to the modern pharmaceutical therapy.
Study on Non-Contact Hold and Transfer Control of Spherical Magnetic Body by Magnetic Robot Hand with Prototype Gap Sensor System

In the exploitation of a magnetic robot hand, it is extremely important to develop a gap sensor of high and stable performance for the relative motion in three dimensional space between the held body and the magnetic robot hand.In this study, first, a prototype gap sensor system for the instrument of the gap between a magnetic robot hand and a spherical magnetic body held and transferred without contact point is developed. The prototype gap sensor system consists of a magnetic flux sensor, an exciting current sensor and a data base calculation system. The data base calculation system is constructed with the instrument data obtained by the beforehand experiments among the gap, the magnetic flux and the exciting current. The magnetic robot hand is composed with the prototype gap sensor system and an electromagnet. Second, the experiments of the non-contact hold and transfer control of the spherical magnetic body have been carried out, and it is confirmed that the spherical magnetic body can be held and transferred successfully without contact point by the magnetic robot hand with the prototype gap sensor system.
Alternative Optimal Filter for Linear State Delay Systems

In this paper, the optimal filtering problem for linear systems with state delay over linear observations is treated using the optimal estimate of the state transition matrix. As a result, the alternative optimal filter is derived in the form similar to the traditional Kalman-Bucy one, i.e., consists of only two equations, for the optimal estimate and the estimation error variance. This presents a significant advantage in comparison to the previously obtained optimal filter by Basin MV, et al (2005), which includes a variable number of covariance equations, unboundedly growing as the filtering horizon tends to infinity. Performances of the two optimal filters are compared in example; the obtained results are discussed
In vivo effect of inactivation of ribosome recycling factor – fate of ribosomes after unscheduled translation downstream of open reading frame

The post‐termination ribosomal complex is disassembled by ribosome recycling factor (RRF) and elongation factor G. Without RRF, the ribosome is not released from mRNA at the termination codon and reinitiates translation downstream. This is called unscheduled translation. Here, we show that at the non‐permissive temperature of a temperature‐sensitive RRF strain, RRF is lost quickly, and some ribosomes reach the 3′ end of mRNA. However, instead of accumulating at the 3′ end of mRNA, ribosomes are released as monosomes. Some ribosomes are transferred to transfer‐messenger RNA from the 3′ end of mRNA. The monosomes thus produced are able to translate synthetic homopolymer but not natural mRNA with leader and canonical initiation signal. The pellet containing ribosomes appears to be responsible for rapid but reversible inhibition of most but not all of protein synthesis in vivo closely followed by decrease of cellular RNA and DNA synthesis.
Outbreak of Subclinical Mastitis in a Flock of Dairy Sheep Associated with Burkholderia cepacia Complex Infection

ABSTRACT An outbreak of subclinical mastitis in a flock of 620 milking sheep was investigated. Microbiological and epidemiological analyses identified the causative agent as belonging to the Burkholderia cepacia complex (formerly Pseudomonas cepacia). Every ewe in the milking flock was individually tested for subclinical mastitis on two separate occasions, 6 weeks apart, by the California (rapid) mastitis test (CMT). The proportion of CMT-positive ewes was 69 of 393 (17.6%) on the first sampling and 27 of 490 (5.5%) on the second sampling. Pure B. cepacia cultures identified with the API 20 NE system were grown from 64 of 96 (66.7%) CMT-positive ewes and from 1 of 33 (3.0%) CMT-negative ewes. Statistical analysis confirmed the significant association between a positive CMT result and a positive culture result for B. cepacia complex. Additional polyphasic taxonomic analyses of eight isolates showed that seven belonged to B. cepacia genomovar III; the remaining isolate was identified as Burkholderia vietnamiensis(formerly B. cepacia genomovar V). Bacteriological investigation of samples from milking equipment and other environmental sites failed to identify “B. cepacia” in any of the samples taken. To our knowledge, this is the first report of an outbreak of natural infection in animals caused by B. cepacia complex and the first description of B. cepacia complex infection in sheep.
Assessing Credibility of Weblogs

Credibility is a perceived quality and is evaluated with at least two major components: trustworthiness and expertise. Weblogs (or blogs) are a potentially fruitful genre for exploration of credibility assessment due to public disclosure of information that might reveal trustworthiness and expertise by webloggers (or bloggers) and availability of audience evaluations. The objectives of the planned exploratory study are to compile a list of factors that users take into account in credibility assessment of blog sites, order them in terms of users’ perceived importance, and determine which factors can be recognized and evaluated with Natural Language Processing (NLP) techniques. With partial automation in mind, we propose an analytical framework for blog credibility assessment based on four profile factors: 1) the blogger’s expertise and the amount of offline identity disclosure, 2) the blogger’s trustworthiness (or the overtly stated value system including beliefs, goals, and values), 3) information quality, and 4) appeals of a personal nature. We describe a multi-stage study that combines a qualitative study of credibility judgments of blog-readers with NLP-based analysis of blogs. The study will elicit and test credibility assessment factors (Phase I), perform NLP-based blog profiling (Phase II), and contentanalyze blog-readers’ comments for partial profile matching (Phase III).
Study the influence of transmission line loss on the performance of matrix amplifiers

An analytical approach is presented to investigate the performance of matrix amplifiers containing both hetero-junction bipolar and high-electron-mobility transistors. An analytical relation for attenuation function of the central line of the matrix amplifier is developed which can be employed in the consideration of the influence of several parameters on the device performance. It is shown that this structure may have lower attenuation respect to the traditional HEMT_HEMT and HEMT_HBT matrix amplifiers. The proposed technique is applicable in improving the performance of Microwave and mm-wave ICs.
ROLE OF INSULIN‐LIKE GROWTH FACTOR 1 AND PHOSPHOINOSITIDE 3‐KINASE IN A SETTING OF HEART DISEASE

1 The insulin‐like growth factor 1 (IGF1)–phosphoinositide 3‐kinase (PI3‐K) pathway is a critical regulator of cell and organ growth. 2 In the heart, the IGF1–PI3‐K pathway induces physiological heart growth with preserved or enhanced cardiac function. 3 The present review specifically discusses the role of the IGF1–PI3‐K pathway in the setting of heart disease. 4 Genetic mouse models have highlighted the beneficial effects of the IGF1–PI3‐K pathway in the heart in a setting of disease. These include maintenance of contractile function, antifibrotic and anti‐apoptotic actions, inhibition of signalling transducers activated in disease settings and regeneration.
Posterior Leukoencephalopathy Syndrome in Children and Adolescents

Posterior leukoencephalopathy syndrome is a recently identified clinical and radiologic entity. The characteristic radiologic findings are bilateral gray and white matter edema in the posterior regions of the cerebral hemispheres. This article reports clinical and radiologic findings in 10 consecutive episodes of posterior leukoencephalopathy syndrome that were diagnosed in 9 children and adolescents. The causes were immunosuppressive therapy in 7 patients and a combination of renal failure and hypertension in 3. The most common presenting symptoms were seizure and altered consciousness; others included headache, sixth nerve palsy, and cortical blindness. Imaging demonstrated abnormalities in the parietal and occipital lobes in all 10 episodes. The signs and symptoms resolved after immunosuppressive agents were reduced or discontinued, or after uremia and hypertension were corrected. Four patients underwent follow-up cranial imaging, and the images showed nearly complete or complete resolution. The syndrome was clinically reversible in all patients.
Myocardin in Tumor Suppression and Myofibroblast Differentiation

The malignant transformation process is associated with defects in cell cycle regulation and disruption of the normal differentiation programs in both neoplastic and adjacent stroma cells. However, the relationships between the cell cycle, differentiation and cancer are very complex and tissue specific. Recently we have demonstrated a previously unrecognized role in human carcinogenesis for the important regulator of cardiac and smooth muscle differentiation, myocardin. Myocardin expression is frequently repressed during human malignant transformation contributing to a differentiation defect in the premalignant mesenchymal cells. TGFβ treatment, serum deprivation and intact contact inhibition response all contribute to myocardin induction and differentiation. Positive regulation of myocardin mRNA levels and activity by the p16/Rb pathway provides a molecular link between cell cycle and differentiation defects during cancer development. In addition, we show that myocardin represses its own expression in human fibroblasts. This negative autoregulatory loop might be potentially important for restraining myocardin activity and allowing reversibility of fibroblast-myofibroblast phenotypic conversion.Here we discuss the emerging role of myocardin in tumor suppression as well as novel aspects of its regulation in normal and malignant conditions.
Improving Calibration of Chemical Gas Sensors for Fire Detection Using Small Scale Setups

Chemical sensing may be better suited than conventional smoke-based detectors for the detection of certain type of fires, in particular in fires where smoke appears after gas emissions. However, chemical-based systems also respond to non-fire scenarios that also release volatiles. For this reason, discrimination models need to be trained under different fire and non-fire scenarios. This is usually performed in standard fire rooms, the access to which is very costly. In this work, we present a calibration model combining experiments from standard fire room and small-scale setup. Results show that the use of small-scale setup experiments improve the performance of the system.
OFSA: Optimum Frame-Slotted Aloha for RFID Tag Collision Arbitration

RFID technologies have attracted a lot of attention in recent years because of their cost/time-effectiveness in large-scale logistics, supply chain management (SCM) and other various potential applications. One of the most important issues of the RFID-based systems is how quickly tags can be identified. Tag collision arbitration plays a more critical role in determining the system performance especially for passive tag-based ones where tag collisions are dealt with rather than prevented. We present a novel tag collision arbitration protocol called Optimum Frame-Slotted Aloha ( OFSA ). The protocol has been designed to achieve time-optimal efficiency in tag identification through an analytic study of tag identification delay and tag number estimation. Results from our analysis and extensive simulations demonstrate that OFSA outperforms other collision arbitration protocols. Also, unlike most prior anti-collision protocols, it does not require any modification to the current standards and architectures facilitating the rollout of RFID systems.
A survey of physical-layer network coding in wireless networks

Network coding (NC) can improve the network performance, facilitate algorithm/protocol design, and deal with application-specific problems in wireless networks. Recently, inspired by the traditional network-layer NC, physical-layer network coding (PLNC) has been proposed to further improve the performance achieved by traditional NC schemes. PLNC has been proven to outperform traditional NC, be able to use physical-layer functionalities, and improve performance on relay communications. PLNC schemes can also use cross-layer information to perform the optimization of network performance. In this paper, up-to-date related issues of PLNC schemes and future trends will be discussed. We can see that PLNC in wireless networks is a promising research area and there is much room left for future contributions.
Detection of flat ground area by single camera on mobile vehicles

For moving robots of outdoor use, it is essential to detect the movable road area. In this research, we propose a new method of making distinction between road points and off-road points that are detected as feature points. Namely, we are to build the projection transformation model of the road seen from the robot in advance, the robot detects feature points by SURF or some other methods, and then making correspondence between the consecutive frames. By inverse projection, the points can be classified into on-road and off-road points. In this paper, we propose the principle of this theory and show some examples.
Biased and Constitutive Signaling in the CC-chemokine Receptor CCR5 by Manipulating the Interface between Transmembrane Helices 6 and 7*

Background: Information about the structure-function relationship and activation mechanism of 7TM receptors is needed. Results: Single mutations in CCR5 induce biased signaling with increased activation through Gαi but decreased β-arrestin recruitment. Conclusion: The TM6/7 interface controls the G protein-dependent and -independent activity state of CCR5. Significance: Knowledge about specific 7TM receptor regions targeted by pathway-selective (biased) ligands is vital for future drug design. The equilibrium state of CCR5 is manipulated here toward either activation or inactivation by introduction of single amino acid substitutions in the transmembrane domains (TMs) 6 and 7. Insertion of a steric hindrance mutation in the center of TM7 (G286F in position VII:09/7.42) resulted in biased signaling. Thus, β-arrestin recruitment was eliminated, whereas constitutive activity was observed in Gαi-mediated signaling. Furthermore, the CCR5 antagonist aplaviroc was converted to a full agonist (a so-called efficacy switch). Computational modeling revealed that the position of the 7TM receptor-conserved Trp in TM6 (Trp-248 in position VI:13/6.48, part of the CWXP motif) was influenced by the G286F mutation, causing Trp-248 to change orientation away from TM7. The essential role of Trp-248 in CCR5 activation was supported by complete inactivity of W248A-CCR5 despite maintaining chemokine binding. Furthermore, replacing Trp-248 with a smaller aromatic amino acid (Tyr/Phe) impaired the β-arrestin recruitment, yet with maintained G protein activity (biased signaling); also, here aplaviroc switched to a full agonist. Thus, the altered positioning of Trp-248, induced by G286F, led to a constraint of G protein active, but β-arrestin inactive and thus biased, CCR5 conformation. These results provide important information on the molecular interplay and impact of TM6 and TM7 for CCR5 activity, which may be extrapolated to other chemokine receptors and possibly to other 7TM receptors.
Robust two degree-of-freedom add-on controller design for automatic steering

A robust 2-DOF add-on controller design based on the disturbance observer is presented in this paper for improved performance in vehicle automatic steering. The application example is the benchmark problem on automatic steering of a city bus with large variations in mass and speed and for which the reference maneuvers and specifications are available in the literature. The analytical formulation of the compensator is presented, followed by evaluation and demonstration of the enhanced model regulation and disturbance rejection properties achieved by its use. Improved steering dynamics can be achieved using yaw rate feedback without the need for a yaw rate sensor. Noting that the steering angle rate actuator saturation forms a major limitation of performance, especially in the presence of the integrating actuator used in the city bus example, the performance enhancement due to the disturbance observer-based add-on compensator is investigated in the presence of actuator saturation. Finally, a disturbance feedforward-based add-on compensator is also presented for well-defined reference trajectories like the entering a bus stop bay maneuver, enabling preview.
An Investigation of Tasks and Techniques Associated With Dynamic Interview Adequacy

We examined the hypotheses that adequately conducted dynamic interviews would be associated with performance on five interview tasks, which, in turn, would be associated with specific clinical techniques. Ten subjects provided two dynamic interviews each, one rated higher and one lower in overall dynamic adequacy. Interviews were independently rated for completion of five interviewer tasks. Another rater independently categorized each therapist intervention as one of 10 therapeutic interventions. Dynamic interview adequacy was associated with four of five interview tasks, attributable to the interviewer's contribution, after controlling for the subject's contribution. Four tasks—frame setting, exploration of affect, interpretation, and synthesis—were associated with specific clinical interventions, whereas offering support was not. The overall thoroughness of completing the interview tasks was highly associated with dynamic adequacy and the ratio of exploratory to supportive interventions. The adequately conducted dynamic interview is associated with identifiable tasks and techniques that should facilitate teaching it for research or clinical use.