Miracle-dz/UniFAR-FTUs huggingface dataset:
Individuals with agenesis of the corpus callosum show sensory processing differences as measured by the sensory profile.

OBJECTIVE Given reports of high pain thresholds and reduced auditory response in individuals with agenesis of the corpus callosum (AgCC), this study investigated whether affected participants report atypical experiences and behaviors on a well-established sensory processing measure. METHODS Fourteen participants with AgCC (ages 11-59) completed the Adolescent/Adult Sensory Profile (Brown & Dunn, 2001). Sensory profile scales were classified as "Atypical" if they were more than 1 standard deviation from the mean. RESULTS Fifty-seven percent of participants with AgCC reported reduced sensory registration as compared to an expected 16% of the normative sample. Similarly, 50% of the AgCC participants reported atypically increased auditory processing difficulties. CONCLUSIONS Using a well-established sensory processing questionnaire, participants with AgCC reported measurable differences in multiple aspects of sensory processing. The most notable difference was in the quadrant of low sensory registration, suggesting that individuals with AgCC may require sensory information to be presented more slowly or at a higher intensity for adequate processing. The sensory modality that was most affected was the auditory system, which is consistent with increased rates of language disorders and autism spectrum disorders in this population. Understanding sensory processing in individuals with AgCC can both elucidate the role of interhemispheric transfer in the development of intact sensory processing as well as contribute to our knowledge of the role of the corpus callosum in a range of disorders in which sensory processes are impacted. (PsycINFO Database Record
The use of bacitracin in the prevention and treatment of experimentally-induced necrotic enteritis in the chicken.

Necrotic enteritis is a widespread and important disease of broiler chickens. There have been several reports recently on the reproduction of the disease using broth cultures of Clostridium perfringens Type A strains (5, 7) or bacteria-free crude toxins (1). Deliberate super-infection with coccidia also has been used to aid experimental production of the disease with C. perfringens (2). The purpose of the work reported here was to study the effect of zinc bacitracin in prevention and treatment of necrotic enteritis.
A Peer-To-Peer Traffic Identification Method Using Machine Learning

The use of peer-to-peer (P2P) applications is growing dramatically, which results in several serious problems such as the network congestion and traffic hindrance. In this paper, a method is proposed to identify the P2P traffic based on the machine learning. The novelty of the proposed method is that it utilizes only the size of packets exchanged between IPs within seconds. By investigating the ratio between the upload and download traffic volume of several P2P applications, a characteristic library is constructed. Then the unknown network traffic can be recognized online using this library. The distinguished features of the proposed method lie in that fast computation, high identification accuracy, and resource-saving capability. Finally, experiment results show the satisfactory performance of the proposed method.
A study of multi-standard radio transmitters for GSM/WCDMA/LTE base stations. (Etude des émetteurs radiofréquences multistandards destinés aux stations de base GSM/WCDMA/LTE)

Contemporary telecommunication Base-Stations for GSM/EDGE, WCDMA/HSPA and LTE are increasingly complex and energy intensive. The favoured solution is a truly multi-standard transmitter known as a single Radio Access Network (single-RAN). Modern base station transmitters are often multi-standard, in that they can support different air-interface standards or modes. However, this is achieved not through concurrent operation of the different standards or 'modes', but by means of reconfiguration, which is inefficient and expensive. We envision a practical, fully multi-mode transmitter capable of simultaneously supporting GSM/EDGE, WCDMA/HSPA and LTE carriers. The evolution of 3GPP standards towards multi-mode operation is in the nascent stage. To contribute to this effort, our work revisits the architecture of the traditional macro-cell Base-Station transmitter in order to analyse and define performance requirements for a multi-standard cellular radio platform. Our system analysis and design also identifies a potential bottleneck in the proposed multi-mode chain, for which analysis is presented. Consequently and lastly, we propose the conceptual design of a variable-gain Analog Quadrature Modulator that bypasses the bottleneck, highlighting scope for future development and validation of this work. This work also brings forth some system-level issues and also highlights challenges in the operation of multi-standard Base-Stations. Some of these include multi-mode signal crest-factor reduction, carrier-to-carrier interference mitigation, per-carrier power-control, etc.
A day-ahead generation scheduling with energy storage considering cycling ramp costs

Variability and uncertainty associated with the growth of variable renewable generation, particularly wind power, introduce significant challenges to grid system operators. This paper proposes a day-ahead chance constraint generation scheduling (CCGS) approach, considering variable wind generation and energy storage. Cycling ramp cost is introduced in this paper as a penalty in the objective cost function, to model the operation and maintenance (O&M) costs, which leads to the reduction of the wear and tear of the generator. The cycling of conventional generation as well as the dispatch of energy storage is utilized to enhance the load following and flexible ramping support capabilities; thus mitigate the impact of net load ramps. The chance constraint is converted into an equivalent mixed-integer linear programming (MILP) expression by using the Projected Disjunctive Reformulation (PDR), with the aim to maintain compatibility with commercially state-of-the-art optimization solvers. Results show the merits of the proposed scheduling model in controlling the fluctuating characteristics due to high wind penetration levels. The impact of introducing cycling ramp cost and the benefits of energy storage in reducing the respective cost, are also investigated in the test cases.
Increased levels of proinflammatory cytokines in the aged rat brain attenuate injury‐induced cytokine response after excitotoxic damage

In order to evaluate proinflammatory cytokine levels and their producing cell types in the control aged rat brain and after acute excitotoxic damage, both adult and aged male Wistar rats were injected with N‐methyl‐D‐aspartate in the striatum. At different survival times between 6 hr and 7 days after lesioning, interleukin‐1 beta (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor alpha (TNF‐α) were analyzed by enzyme‐linked immunosorbent assay and by double immunofluorescence of cryostat sections by using cell‐specific markers. Basal cytokine expression was attributed to astrocytes and was increased in the normal aged brain showing region specificity: TNF‐α and IL‐6 displayed age‐dependent higher levels in the aged cortex, and IL‐1β and IL‐6 in the aged striatum. After excitotoxic striatal damage, notable age‐dependent differences in cytokine induction in the aged vs. the adult were seen. The adult injured striatum exhibited a rapid induction of all cytokines analyzed, but the aged injured striatum showed a weak induction of cytokine expression: IL‐1β showed no injury‐induced changes at any time, TNF‐α presented a late induction at 5 days after lesioning, and IL‐6 was only induced at 6 hr after lesioning. At both ages, in the lesion core, all cytokines were early expressed by neurons and astrocytes, and by microglia/macrophages later on. However, in the adjacent lesion border, cytokines were found in reactive astrocytes. This study highlights the particular inflammatory response of the aged brain and suggests an important role of increased basal levels of proinflammatory cytokines in the reduced ability to induce their expression after damage. © 2009 Wiley‐Liss, Inc.
Expanded Lysine Acetylation Specificity of Gcn5 in Native Complexes*

The coactivator/adaptor protein Gcn5 is a conserved histone acetyltransferase, which functions as the catalytic subunit in multiple yeast transcriptional regulatory complexes. The ability of Gcn5 to acetylate nucleosomal histones is significantly reduced relative to its activity on free histones, where it predominantly modifies histone H3 at lysine 14. However, the association of Gcn5 in multisubunit complexes potentiates its nucleosomal histone acetyltransferase activity. Here, we show that the association of Gcn5 with other proteins in two native yeast complexes, Ada and SAGA (Spt-Ada-Gcn5-acetyltransferase), directly confers upon Gcn5 the ability to acetylate an expanded set of lysines on H3. Furthermore Ada and SAGA have overlapping, yet distinct, patterns of acetylation, suggesting that the association of specific subunits determines site specificity.
Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis

Cognitive dysfunction is considered one of the clinical markers of multiple sclerosis (MS). However, in the literature there are inconsistent reports on the prevalence of cognitive dysfunction, and separate data for the relapsing-remitting (RR) type of the disease are not always presented. In this study, we submitted 461 RRMS patients to a battery of neuropsychological tests to investigate their impairment in various cognitive domains. As a consequence of the exclusion criteria, the sample is not fully representative of the entire population of RRMS patients. In this selected sample, when only the eight scores of a core battery (Mental Deterioration Battery) were considered (with respective cutoffs), it emerged that 31% of the patients were affected by some degree of cognitive deficit. In particular, 15% had mild, 11.2% moderate and 4.8% had severe impairment. Information processing speed was the most frequently impaired area, followed by memory. When two other tests (SDMT and MCST) were added and cognitive domains were considered, it emerged that 39.3% of the patients were impaired in two or more domains. When four subgroups were obtained by means of cluster analysis and then compared, it emerged that information processing speed and memory deficits differentiated the still cognitively unimpaired from the mildly impaired MS patients. Significant associations were found between cognitive and clinical characteristics. However, due to the large sample size, clinically irrelevant relationships may also have emerged. Even with the limitations imposed by the sample selection and the possible underestimation of the prevalence and severity of cognitive dysfunction, these results seem to provide further evidence that information processing speed deficit may be an early and important marker of cognitive impairment in MS patients.
Supporting group collaboration in Wiki by increasing the awareness of task conflict

Purpose – Wiki forms a new model of virtual collaboration. The original wiki is designed to hide content authorship information. Such design may hinder users from being aware of task conflict, resulting in low-efficient conflict management and decreased group performance. This study aims at increasing users' awareness of task conflict to facilitate wiki-based collaboration. Design/methodology/approach – A visual feedback dialog box is designed to increase users' awareness of task conflict. A survey-based comparative study is conducted by using original wiki and modified wiki (the new design). A total of 301 participants are invited. Structural equation model (SEM) is used to analyze survey data. Findings – Most users are willing to solve conflict issues, and the dialog box can increase users' awareness of task conflict. Conflict awareness can promote user's participation, gain better conflict resolution and improve group performance. The dialog box can enhance the influence of conflict awareness on user p.
OWL, RDF, RDFS inference derivation using Jena semantic framework & pellet reasoner

Semantic web is an extension of World Wide Web. In Semantic web each resources and services is annotated with the help of web ontology language (OWL). Resource description framework (RDF) represents the web information into its properties and values. Resource description framework schema (RDFS) represents information resources into classes and properties are defined with the help of these classes. In this paper we create university ontology with the help of protégé 4.3 alpha tool. We have proposed information retrieval framework that produce results with better precision, recall and information overkill. With the help of Jena semantic framework and pellet reasoner tools we analyze that OWL inference provide more relevant information compared to None, RDF and RDFS. We have developed five university domain ontologies but presented the result only for two ontologies. We have validated that our proposed framework provide more relevant information for these two ontologies.
Prognostic factors in acute stroke, regarding to stroke severity by Canadian Neurological Stroke Scale: A hospital-based study

Introduction: Stroke is an acute vascular disease and the second leading cause of death in the world. We have assessed the patients on hospital admission with some other prognostic factors besides the preliminary neurological examinations in order to estimate their clinical status in the future. Materials and Methods: The present study was performed on the patients admitted to Valiasr Hospital of Arak within 72 h of stroke onset from April to October 2011. Diagnosis of stroke in the suspected patients was done by a neurologist and verified by the findings of the computed tomography scans. For each patient, a specific questionnaire, which described its stroke severity according to canadian neurological scale of stroke (CNSS), was prepared in order to define the severity of the stroke. Systolic as well as diastolic blood pressure of the patients was measured at the admission and their level of blood sugar, cholesterol, and triglyceride was also determined. Results: Out of 62 patients under study (mean age, 66.14 ± 10.9 years), 36 (58.1%) were males and 26 (41.9%) were females. Overall, 66.1% of the patients were diagnosed with the ischemic stroke, while 33.9% were diagnosed with the hemorrhagic stroke. Regression analysis showed that cholesterol and diastolic blood pressure were the most important prognostic factors of the severity of stroke (CNSS). Conclusion: Diastolic blood pressure and serum cholesterol level have the potential to be used for assessing the stroke outcome as well as to improve the stroke rehabilitation.
Comparison of topical lidocaine [2% gel] and injectable lidocaine [2% solution] for incision and curettage of chalazion in Ilorin, Nigeria.

AIMS AND OBJECTIVES To compare the efficacy and side effects profile of topical 2% lidocaine gel with injectable 2% lidocaine solution as local anaesthetics for incision and curettage of chalazion. PATIENTS AND METHODS Overa 12 month period, 61 patients with unilateral chalazia who were scheduled for incision and curettage surgery under local anaesthesia were randomized into 2 groups: A & B. Group A received 1.5 ml of injectable lidocaine as local anaesthetic while Group B received 1.5 ml of lidocaine 2% gel topically. The major outcome of interest was pain experienced during anaesthetic administration and surgery. RESULTS Mean pain score from anaesthesia administration was significantly higher in the injection group (A = 4.46 vs. B = 0.57), (p = 0.000005). There was a statistically significant difference in mean pain score during incision and curettage with more pain in the gel group (A = 2.84 vs. B = 4.83), (p = 0.0012). However, the mean total pain score (surgery plus anaesthesia) was more in the injection than the gel group (A = 7.3 vs. B = 5.4) (p = 0.0094). The proportions that had no fear for injection were 54.8% in A and 56.7 % in B. Group A had significantly more ptosis than Group B (2.2 vs. 1.4, p = 0.00003,). Bleeding occured in 93.5% in group A while none occurred in Group B (p = 0.000). CONCLUSION Lidocaine 2% gel is an effective, safe and convenient alternative to injectable lidocaine 2% as local anaesthetic agent in incision and curettage for Chalazion in this study.
Cyclone: High Availability for Persistent Key Value Stores

Persistent key value stores are an important component of many distributed data serving solutions with innovations targeted at taking advantage of growing flash speeds. Unfortunately their performance is hampered by the need to maintain and replicate a write ahead log to guarantee availability in the face of machine and storage failures. Cyclone is a replicated log plug-in for key value stores that systematically addresses various sources of this bottleneck. It uses a small amount of non-volatile memory directly addressable by the CPU - such as in the form of NVDIMMs or Intel 3DXPoint - to remove block oriented IO devices such as SSDs from the critical path for appending to the log. This enables it to address network overheads using an implementation of the RAFT consensus protocol that is designed around a userspace network stack to relieve the CPU of the burden of data copies. Finally, it provides a way to efficiently map the commutativity in key-value store APIs to the parallelism available in commodity NICs. Cyclone is able to replicate millions of small updates per second using only commodity 10 gigabit ethernet adapters. As a practical application, we use it to improve the performance (and availability) of RocksDB, a popular persistent key value store by an order of magnitude when compared to its own write ahead log without replication.
A generalization of Fagin's theorem

Fagin's theorem characterizes NP as the set of decision problems that are expressible as second-order existential sentences, i.e., in the form (/spl exist//spl Pi/)/spl phi/, where /spl Pi/ is a new predicate symbol, and /spl phi/ is first-order. In the presence of a successor relation, /spl phi/ may be assumed to be universal, i.e., /spl phi//spl equiv/(/spl forall/x~)/spl alpha/ where /spl alpha/ is quantifier-free. The PCP theorem characterizes NP as the set of problems that may be proved in a way that can be checked by probabilistic verifiers using O(log n) random bits and reading O(1) bits of the proof: NP=PCP[log n, 1]. Combining these theorems, we show that every problem D/spl isin/NP may be transformed in polynomial time to an algebraic version D/spl circ//spl isin/NP such that D/spl circ/ consists of the set of structures satisfying a second-order existential formula of the form (/spl exist//spl Pi/)(R/spl tilde/x~)/spl alpha/ where R/spl tilde/ is a majority quantifier-the dual of the R quantifier in the definition of RP-and /spl alpha/ is quantifier-free. This is a generalization of Fagin's theorem and is equivalent to the PCP theorem.
mRNAs encoding aquaporins are present during murine preimplantation development

The present study was conducted to investigate the mechanisms underlying fluid movement across the trophectoderm during blastocyst formation by determining whether aquaporins (AQPs) are expressed during early mammalian development. AQPs belong to a family of major intrinsic membrane proteins and function as molecular water channels that allow water to flow rapidly across plasma membranes in the direction of osmotic gradients. Ten different AQPs have been identified to date. Murine preimplantation stage embryos were flushed from the oviducts and uteri of superovulated CD1 mice. Reverse transcription–polymerase chain reaction (RT‐PCR) methods employing primer sets designed to amplify conserved sequences of AQPs (1–9) were applied to murine embryo cDNA samples. PCR reactions were conducted for up to 40 cycles involving denaturation of DNA hybrids at 95°C, primer annealing at 52–60°C and extension at 72°C. PCR products were separated on 2% agarose gels and were stained with ethidium bromide. AQP PCR product identity was confirmed by sequence analysis. mRNAs encoding AQPs 1, 3, 5, 6, 7, and 9 were detected in murine embryos from the one‐cell stage up to the blastocyst stage. AQP 8 mRNAs were not detected in early cleavage stages but were present in morula and blastocyst stage embryos. The results were confirmed in experimental replicates applied to separate embryo pools of each embryo stage. These results demonstrate that transcripts encoding seven AQP gene products are detectable during murine preimplantation development. These findings predict that AQPs may function as conduits for trophectoderm fluid transport during blastocyst formation. Mol. Reprod. Dev. 57:323–330, 2000. © 2000 Wiley‐Liss, Inc.
Embedded importance watermarking for image verification in radiology

Digital medical images used in radiology are quite different to everyday continuous tone images. Radiology images require that all detailed diagnostic information can be extracted, which traditionally constrains digital medical images to be of large size and stored without loss of information. In order to transmit diagnostic images over a narrowband wireless communication link for remote diagnosis, lossy compression schemes must be used. This involves discarding detailed information and compressing the data, making it more susceptible to error. The loss of image detail and incidental degradation occurring during transmission have potential legal accountability issues, especially in the case of the null diagnosis of a tumor. The work proposed here investigates techniques for verifying the voracity of medical images - in particular, detailing the use of embedded watermarking as an objective means to ensure that important parts of the medical image can be verified. We propose a result to show how embedded watermarking can be used to differentiate contextual from detailed information. The type of images that will be used include spiral hairline fractures and small tumors, which contain the essential diagnostic high spatial frequency information.
Treatment Outcomes in Anxious Youth with and without Comorbid ADHD in the CAMS

The purpose of this study is to examine the influence of Attention-Deficit/Hyperactivity Disorder (ADHD), independent of Oppositional Defiant Disorder (ODD), on acute treatment response, remission rates and maintenance of gains at 6-month follow-up in anxious youth (ages 7–17, 76% Caucasian, 52% female) who received cognitive-behavioral therapy (CBT) alone, pharmacotherapy alone, the combination of CBT and pharmacotherapy or placebo pill in the Child/Adolescent Multimodal Study. Treatment response was defined as independent evaluator rated meaningful improvement in anxiety. Remission was operationalized as the absence of targeted anxiety disorders. ADHD and ODD were examined as moderators of outcomes at a diagnostic level. In the CBT group only, an ADHD diagnosis predicted poorer immediate treatment response and remission rates. However, these associations were not obtained for the pharmacotherapy groups. Participants with comorbid ODD were not less likely to achieve acute treatment response and remission rates than their counterparts across treatment conditions. Due to small sample size of the comorbid subgroups, our analyses must be considered preliminary. Nevertheless, our initial findings suggest further exploration of the separate roles of ADHD and ODD are worth pursuing, as they may be differentially associated with treatment outcomes in anxious youth treated with CBT but not youth treated with pharmacotherapy. If confirmed, findings may indicate that anxious youth with comorbid ADHD are less likely to benefit from CBT strategies alone and raise the possibility that these youth need adjunctive pharmacotherapy or psychosocial interventions.