Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of streptomycin on stretch-induced electrophysiological changes of isolated acute myocardial infarcted hearts in rats.

AIMS To explore whether the stretch of ischaemic myocardium could modulate the electrophysiological characteristics, especially repolarization via mechanoelectric feedback (MEF), as well as the effect of streptomycin (SM) on these changes. Methods Thirty-six wistar rats were randomly divided into four groups: control group (n = 9), SM group (n = 9), myocardial infarction (MI) group (n = 9), and MI + SM group (n = 9). After perfused on Langendorff, the isolated hearts were stretched for 5s by a ballon inflation of 0.2mL. After being stretched, the effect of the stretch was observed for 30s, including the 20, 20-70, 70, and 90% monophasic action potential duration (MAPD), i.e. MAPD(20), MAPD(20-70), MAPD(70), and MAPD(90), respectively, premature ventricular beats (PVB), and ventricular tachycardia (VT). Results The stretch caused a decrease in MAPD(20-70) (both P <0.01) and an increase in MAPD(90) (both P <0.01) in both control and MI groups. Moreover, the MAPD(90) in the MI group had increased more significantly than that in the control group (P <0.05). A concentration of 200 micromol/L of SM had no influence on both MAPD(20-70) and MAPD(90) of basic state (P > 0.05, except MAPD(20-70) between the control and SM groups, P < 0.01), whereas it had reduced the length of MAPD(90) (P < 0.05) and inhibited the decrease in MAPD(20-70) induced by the inflation. There was a decrease in the tendency of MAPD(70) after the stretch (P = NS) and SM had reversed the tendency, whereas MAPD(20) had no obvious changes after inflation. The incidence rate of PVB and VT in the MI group was higher than that in the control group after inflation (P < 0.01). The 200 micromol/L SM reduced the incidence rate of PVB, and obviously inhibited the occurrence of VT (P < 0.01). CONCLUSIONS Stretch could alter the electrophysiological activities of myocardium via MEF, which could enhance in acute myocardial infarction and facilitate the generation and maintenance of malignant arrhythmias. SM could significantly inhibit the occurrence of arrhythmias, which may correlate with the effect on blocking stretch-activated ion channels.
The Medicare Part D Coverage Gap: Implications for Non-Dually Eligible Older Adults With a Mental Illness

This study examines how the Medicare Part D coverage gap impacts non-dually eligible older adults with a mental illness. Qualitative, semistructured interviews were conducted with 11 case managers from community-based agencies serving persons, age 55 and over, with a mental disorder. Five themes illustrating the central difficulties associated with the Part D gap emerged: medication affordability, beneficiary understanding, administrative barriers, Low-Income Subsidy income and asset guidelines, and medication compliance. Although the Patient Protection and Affordable Care Act gradually reduces cost sharing within the gap, findings suggest that medication access and adherence may continue to be impacted by the benefit's structure.
La industria del software en Brasil: ¿un mercado interno fuerte puede promover las exportaciones?

Con un valor de mercado cercano a 10000 millones de dolares en 2006, equivalente a 50% del total latinoamericano, la industria de software y servicios de informacion brasilena enfrenta el doble reto de admitir a las empresas transnacionales en su mercado interno, al tiempo que busca explotar sus ventajas competitivas para ampliar su presencia en los mercados internacionales. Ambos aspectos se analizan en el presente estudio.
Investigation of the Contextual Interference Effect in the Manipulation of the Motor Parameter of Over-All Force

This investigation examined the contextual interference effect when manipulating over-all force in a golf-putting task. Undergraduate women (N = 30) were randomly assigned to a Random, Blocked-Random, or Blocked practice condition and practiced golf putting from distances of 2.43 m, 3.95 m, and 5.47 m during acquisition. Subjects in the Random condition practiced trials in a quasirandom sequence and those in the Blocked-Random condition practiced trials initially in a blocked sequence with the remainder of the trials practiced in a quasirandom sequence. In the Blocked condition subjects practiced trials in a blocked sequence. A 24-hr. transfer test consisted of 30 trials with 10 trials each from 1.67 m, 3.19 m, and 6.23 m. Transfer scores supported the Magill and Hall (1990) hypothesis that, when task variations involve learning parameters of a generalized motor program, the benefit of random practice over blocked practice would not be found.
Distributed Constraint Logic Programming

Distributed and constraint logic programming - a brief history Parlog, Pandora and their abstract machine the multi-Pandora model and the multi-Pandora abstract machine distributed implementation of Parlog distributed implementation of Pandora distributed implementation of multi-Pandora finite domain constraints in distributed concurrent logic programming languages distributed constraint concurrent logic programming distributed constraint solver in the domain of real numbers distributed constraint solver in the domain of Boolean rings integrating distributed constraint solvers and distributed logic programming languages conclusions and future work.
Relay selection for secure cooperative networks with jamming

This paper deals with relay selection in cooperative networks with secrecy constraints. The proposed scheme enables an opportunistic selection of two relay nodes to increase security against eavesdroppers. The first relay operates as a conventional mode and assists a source to deliver its data to a destination via a decode-and-forward strategy. The second relay is used in order to create intentional interference at the eavesdropper nodes. The proposed selection technique jointly protects the primary destination against interference and eavesdropping and jams the reception of the eavesdropper. The new approach is analyzed for different complexity requirements based on instantaneous and average knowledge of the eavesdropper channels. In addition an investigation of an hybrid security scheme which switches between jamming and non-jamming protection is discussed in the paper. It is proven that an appropriate application of these two modes further improves security. The enhancements of the proposed selection techniques are demonstrated analytically and with simulation results.
Classification of Old/New effects during memory retrieval Using Committee Machine: an Event-Related Potential study

The task of old/new items recognition associated with memory process has assessed by ERPs in present study. The recognition paradigm with random shape items was administered to 27 young participants. Event-related potentials were recorded during an old/new discrimination task on Fz, Cz and Pz channels. In order to classify old/new responses, wavelet features which are compatible with ERP characteristics in Time-frequency domain were used as discriminator features. Best features were selected using t-test and stepwise linear discriminant analysis method afterward. Linear discriminant analysis was applied as classifier between two groups. Finally, using committee machine, event related potentials associated with old/new effects, were separated with 96.4% accuracy in test group.
Semantic Query Expansion using Cluster Based Domain Ontologies

Information on the web has been growing at a very rapid pace and has become quite voluminous over the past few years. The users search query on the web could not retrieve sufficient relevant documents and is responsible for low precision of search results. To improve the precision of search results, an algorithm is proposed in this paper for semantic query expansion using domain ontology based on clustered web query sessions. Domain ontology is created for each cluster of query sessions. The input query of a user is used to select the most similar cluster. The domain ontology of the selected cluster is used to suggest the related concepts for query expansion and the expanded query is used for information retrieval to test its effectiveness. The experiment was conducted on the captured user query sessions on the web and results prove the efficacy of the proposed approach.
Space-frequency-time coded OFDM for broadband wireless communications

In this paper, we propose and analyze an efficient space-frequency-time coded OFDM technique for high-speed transmission over wireless links. Joint use of space-time trellis coding and space-time block coding is considered. It is shown that the maximum achievable diversity order increases linearly not only with the number of transmit and receive antennas but also with the number of multiple paths provided that a proper joint coding scheme is employed. Because of the orthogonality of space-time block codes, space-time trellis codes with low trellis complexity can be used to efficiently achieve the full diversity provided by the fading channel. This is in contrast to traditional space-frequency coded OFDM systems, where we need to design space-time trellis codes with very high trellis complexity to exploit the maximum achievable diversity of the fading channel. Numerical results are provided to demonstrate the significant performance improvement achieved by the proposed space-frequency-time coded OFDM technique.
HEVC video encoder implementation on Texas Instruments platforms

This paper presents a high efficiency video encoder implementation (HEVC) on two different Texas Instruments (Tl) platforms: the BeagleBoard-xM based on ARM processor and the TMS320C6678 DSP. The new features of these processors such as multicore architecture, high frequency processor and low power consumption motivate researchers to develop an embedded HEVC video encoder which could be exploited in several multimedia applications such as High Definition (HD)TV, smart cameras, HD video conference, Ultra HD video surveillance systems. Different operating systems (OS) with different compilers are tested in order to obtain an optimized HEVC encoder implementation. Experimental results show that HEVC encoder DSP-based solution using SYS BlOS real time OS allows saving up to 62% of encoding time compared to Linux-c6x OS with the same DSP and about 71% of encoding time compared to BeagleBoard-based solution without inducing any performance degradation in terms of video quality or bitrate.
An energy saving scheme for key management protocol in IEEE802.16e

In IEEE 802.16e, energy management is an important factor to be emphasized especially for Mobile Stations (MSs) due to their limitation on battery capabilities. Efficient energy scheme would guarantees long lifetime for MSs. In WiMAX service, the Base Station (BS) sends security keys to MSs using key management scheme, and MSs need to perform ciphering operations to get access to the security keys for further processing. In this way, performing high ciphering operations by MSs require more energy. This paper proposes an Efficient Key Management Scheme (EKMS) using complete binary tree structure to mitigate this issue, this is done by reducing energy consumption of MSs needed to execute key management process. Analysis shows that EKMS save energy in MSs during key management.
Benchmarking of dynamic simulation predictions in two software platforms using an upper limb musculoskeletal model

Several opensource or commercially available software platforms are widely used to develop dynamic simulations of movement. While computational approaches are conceptually similar across platforms, technical differences in implementation may influence output. We present a new upper limb dynamic model as a tool to evaluate potential differences in predictive behavior between platforms. We evaluated to what extent differences in technical implementations in popular simulation software environments result in differences in kinematic predictions for single and multijoint movements using EMG- and optimization-based approaches for deriving control signals. We illustrate the benchmarking comparison using SIMM–Dynamics Pipeline–SD/Fast and OpenSim platforms. The most substantial divergence results from differences in muscle model and actuator paths. This model is a valuable resource and is available for download by other researchers. The model, data, and simulation results presented here can be used by future researchers to benchmark other software platforms and software upgrades for these two platforms.
Expression of BUBR 1 in human oral potentially malignant disorders and squamous cell carcinoma

Objective. BUBR1 is one of the key components of the spindle assembly checkpoint (SAC) machinery and is activated in response to kinetochore tension. Defects in the SAC contribute to an increased rate of aneuploidization during tumorigenesis. The aim of the present study was to examine the immunohistochemical expression of BUBR1 protein for human oral squamous cell carcinogenesis. Study design. A total of 120 samples of squamous cell carcinoma (SCC, n 43) and 5 types of potentially malignant disorders (PMDs: oral epithelial dysplasia, n 11; hyperkeratosis/epithelial hyperplasia, n 20; lichen planus, n 16; submucous fibrosis, n 19; and verrucous hyperplasia, n 11) of human oral mucosa (1991-2001) from our institution were retrieved and immunohistochemical staining were performed. Normal oral mucosa (n 9) and fibrous hyperplasia (n 9) from patients without the aforementioned oral habits were also included in the study. Results. BUBR1 staining was detected at the basal and suprabasal layers in 75 (97.4%) of 77 samples of PMD and 43 (100%) of 43 samples of SCC of oral mucosa but was absent in all samples of normal oral mucosa (n 9) and fibrous hyperplasia (n 9). BUBR1 expression of various types of PMD and SCC of oral mucosa was significantly overexpressed as compared respectively with normal mucosa (P .001) and fibrous hyperplasia (P .001). Moreover, the expression of oral SCC was significantly higher as compared respectively with the 5 types of oral PMD; on the other hand, BUBR1 expression of verrucous hyperplasia was significantly higher than that of the other 4 types of PMD of oral mucosa (P .001). Conclusion. Our results may interpret that BUBR1 protein is suggested to be one of the contributing factors involved in the pathogenesis of oral SCC. These also hypothesize that BUBR1 protein is a putative biomarker for human oral squamous cell carcinogenesis. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;109:257-267)
Topological Spatio–Temporal Reasoning and Representation

We present here a theory of motion from a topological point of view, in a symbolic perspective. Taking space–time histories of objects as primitive entities, we introduce temporal and topological relations on the thus defined space–time to characterize classes of spatial changes. The theory thus accounts for qualitative spatial information, dealing with underspecified, symbolic information when accurate data are not available or unnecessary. We show that these structures give a basis for commonsense spatio–temporal reasoning by presenting a number of significant deductions in the theory. This can serve as a formal basis for languages describing motion events in a qualitative way.
Impact of location data freshness on routing in VANETs

In this paper, we propose a combination of GPSR (Greedy Perimeter Stateless Routing) and Hierarchical Location Service (HLS). They used to be combined in the original work with a direct method, i.e. GPSR takes care of routing packets and HLS is called to get destination position when the target node position is unknown or is not fresh enough. When a destination is quite far away from the sender, the exact position of the target is first calculated. An extra overhead is generated from the sender to the receiver. Our aim in this paper, is to reduce this overhead. Then, when we send the packet to the former region where the destination was supposed to be. When the packet enters into the same region than the target, an HLS request is sent to determine the exact position of the destination. In order to implement this concept, we have proposed a patch over the NS-2 simulator which mixes both GPSR and HLS according to our proposal. We have conducted various simulations and we have varied the freshness of the destination location data. The obtained results are promising in terms of latency, packet delivery rate and overhead.
Petroleum hydrocarbon utilization by some molecularly identified filamentous marine fungi isolated from a polluted area in the Mediterranean Sea.

HREE DIFFERENT newly isolated marine fungi were subjected . to 18S rRNA gene partial sequence analysis. The resulting sequences showed that the isolates belong to Fusarium solani, Trichoderma viride and Aspergillus niger. The isolates have the ability to utilize some petroleum hydrocarbons such as hexane, motor oil and diesel oil. The tested fungi could grow up to 7 days, especially on medium supported with diesel oil. Although all of the tested fungi have the ability to utilize the increased concentrations of diesel oil, Fusarium solani EH has the highest ability, growing at a concentration of 4 ml/l. Static and shaking incubation conditions of Fusarium solani EH with 7.2 mg/100ml diesel oil as a sole carbon source, showed significant decrease in the hydrocarbon concentration (90.28% and 93.05%, respectively) within 7 days. Results of this study may provide a help in petroleum hydrocarbon spill clean-up.
Pitch range is not pitch range

This paper presents a phonetic analysis of pitch range as perceived and measured on utterance and syllable level. A previous analysis of read speech showed that German speakers produced a larger pitch-range on utterance level, whereas Swiss German speakers produced a larger pitch-range on syllable level. This analysis was based on the production of broadcasters reading news messages and a fairytale, both stylistically very restricted and largely standardized. Therefore, in the present study semi- and spontaneous utterances are analyzed to provide evidence that these findings are crosslinguistic rather than discourse-specific. The evidence was provided by auditory annotation and acoustic measurements.
Identification of the RecR Toprim Domain as the Binding Site for both RecF and RecO

The RecR protein forms complexes with RecF or RecO that direct the specific loading of RecA onto gapped DNA. However, the binding sites of RecF and RecO on RecR have yet to be identified. In this study, a Thermus thermophilus RecR dimer model was constructed by NMR analysis and homology modeling. NMR titration analysis suggested that the hairpin region of the helix-hairpin-helix motif in the cavity of the RecR dimer is a binding site for double-stranded DNA (dsDNA) and that the acidic cluster region of the Toprim domain is a RecO binding site. Mutations of Glu-84, Asp-88, and Glu-144 residues comprising that acidic cluster were generated. The E144A and E84A mutations decreased the binding affinity for RecO, but the D88A did not. Interestingly, the binding ability to RecF was abolished by E144A, suggesting that the region surrounding the RecR Glu-144 residue could be a binding site not only for RecO but also for RecF. Furthermore, RecR and RecF formed a 4:2 heterohexamer in solution that was unaffected by adding RecO, indicating a preference by RecR for RecF over RecO. The RecFR complex is considered to be involved in the recognition of the dsDNA-ssDNA junction, whereas RecO binds single-stranded DNA (ssDNA) and ssDNA-binding protein. Thus, the RecR Toprim domain may contribute to the RecO interaction with RecFR complexes at the dsDNA-ssDNA junction site during recombinational DNA repair mediated by the RecFOR.
Understanding Spyware: Risk and Response

Spyware - programs that monitor a computer user's activities and capture data about the user, storing the information so a third party can access it s a relatively new phenomenon. Spyware countermeasures are just now maturing beyond their initial capabilities, with many choices available to enterprises and individual users. As this field matures, threats and responses are becoming more sophisticated. One major concern has been the time lag between how quickly threats have evolved compared to how quickly counter-measures become available to deal with the threats. Spyware has evolved rapidly because of the profit motivation that spurs it forward. The good news is that countermeasures will grow dramatically in the near future, also because of a strong - and only recently recognized - profit potential. This will help the response catch up to the threat, but only if IT professionals understand how spyware works.
Equivalent circuit of a quadraxial feed for ultra-wide bandwidth quadruple-ridged flared horn antennas

An equivalent circuit model of a quadraxial feed for ultra-wide bandwidth quadruple-ridged flared horn (QRFH) antennas is presented. The circuit is synthesised by only 3 unknowns and achieves an accurate input impedance for a wide range of dimensions. This model allows fast synthesis of optimal feeding designs that would ensure the excitation of the fundamental mode at the input of Pa QRFH.
A novel snake venom‐derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury

Ischaemic stroke is a serious disease with limited therapy options. Glycoprotein (GP)Ib binding to von Willebrand factor (vWF) exposed at vascular injury initiates platelet adhesion and contributes to platelet aggregation. GPIb has been suggested as an effective target for antithrombotic therapy in stroke. Anfibatide is a GPIb antagonist derived from snake venom and we investigated its protective effect on experimental brain ischaemia in mice.
Expansion of laser-generated plumes near the plasma ignition threshold

Expansion of laser-produced plumes on a solid-vacuum in’ terface during and after the laser shot was investigated theoretically, incorporating several new features into our previous one-component one-dimensional hydrodynamic model. Time development of density, velocity, temperature, and pressure profiles was calculated at laser irradiances below and above the plasma ignition threshold. The estimated velocity of ions released from the plume was close to the measured values. The fast spreading of the blow-off material under the laser vaporization regime and the long lifetime of the relatively compact plasma core above the ignition threshold were predicted in agreement with experimental observations. Cakulated surface recession due to evaporation provided a Jower bound to the measured crater depth, whereas the calculated melt depth proved to be a realistic upper limit.
Nuevo enfoque en la estimación del componente anormal del resultado

Un aspecto crucial en el analisis de la informacion financiera son las posibles manipulaciones introducidas de forma discrecional por los directivos en la informacion que dan a conocer a los usuarios. En este contexto, este trabajo se centra en el analisis de los ajustes por devengo como potencial instrumento a disposicion de la discrecionalidad de los elaboradores de la informacion financiera. Concretamente, se plantea un modelo desagregado de estimacion de ajustes por devengo anormales en el que cada componente se controla por las variables de las que efectivamente depende. El analisis de especificacion y potencia del contraste de earnings management muestra resultados superiores a los planteamientos de panel derivados del clasico modelo de Jones (1991).