Miracle-dz/UniFAR-FTUs huggingface dataset:
Connection between patient and therapist and therapist's competence in schema-focused therapy of personality problems

Abstract The aim of this study was to examine whether the connection between patient and therapist, therapist competence, and the interaction between connection and competence, measured in the early process of schema-focused therapy of personality problems, influenced treatment outcome. Connection is a rater-observed measure of the intimacy and mutual engagement between patient and therapist that appears to represent an easily observable aspect of the therapeutic alliance. The sample consisted of 35 patients with panic disorder and/or agoraphobia and DSM–IV Cluster C personality traits who participated in an 11-week inpatient program. Patients and an expert observer rated the schema-focused individual therapy sessions. Better observer-rated connection in the first session predicted greater across-session reduction in the strength of belief in the particular schemas addressed in the individual therapies. Connection was unrelated to across-session symptomatic improvement and to overall change. Competence predicted a reduction in maladaptive schemas during the schema-focused treatment and in the number of Cluster C personality traits from pretreatment to the follow-up period but was unrelated to across-session change. There was no interaction between connection and competence, indicating that they influenced treatment independently of each other.
Formal specification and verification of distributed component systems

Les phospholipases A2 secretees (sPLA2) sont de puissants inhibiteurs de l’entree du virus de l’immunodeficience humaine (HIV) (Fenard et al. , 1999). Afin de mieux comprendre leur mecanisme d’action, nous avons clone un HIV resistant a la sPLA2 de venin d’abeille (bvPLA2), HIVRBV-3. Mon projet de these a consiste en l’elucidation des mecanismes moleculaires qui conferent sa resistance a HIVRBV-3. Il est bien documente que le HIV penetrant dans la cellule par fusion de la membrane virale avec la membrane plasmique. Par ailleurs, il est generalement admis que les HIV penetrant dans la cellule par la voie endosomale sont degrades dans les lysosomes et ne sont donc pas infectieux. Nous avons montre, avec trois techniques d’analyse differentes, que la voie d’entree de HIVRBV-3 est dependante des endosomes et de leurs moteurs cytosqueletiques. En effet, la replication de HIVRBV-3 est sensible a plusieurs types d’inhibiteurs de l’acidification des endosomes et de la polymerisation des micro-filaments d’actine et ce, dans differents types cellulaires. Nous montrons que ce mecanisme d’entree original ainsi que la resistance a bvPLA2 sont supportes par la glycoproteine d’enveloppe (gp160) de HIVRBV-3. Nos recherches en cours consistent a demontrer l’implication de modification singuliere de certaines boucles variables de la gp120 de HIVRBV-3 dans ce mecanisme d’entree inedit. Les donnees de la bibliographie indiquent que ces modifications de la gp120 sont retrouvees dans les souches virales isolees chez les patients non progresseurs a long terme. Notre hypothese actuelle est donc que les sPLA2 humaines pourraient jouer un role dans le controle de la replication virale chez ces individus.
Response Time Reduction and Performance Analysis of Load Balancing Algorithms at Peak Hours in Cloud Computing

are living in Digital Age which is undoubtedly the outcome of highly developed internet and its corresponding technologies. Cloud computing has become prominent as more people, organizations, entrepreneur, are moving towards it as it facilitates them to achieve their dreams in less investment. Now people from all over the globe are demanding for various services in rapid rate which has lead to bursty workloads on data centers thereby creating peak hour optimization problem to be handled. It has also lead to problem of load balancing which should be addressed to increase the efficiency of data centers. In the present work, peak hour optimization is being aimed and algorithms are being analyzed for large scale application to find efficient algorithm for real time scenario. Further, a novel strategy is being proposed to decrease the response time and DC processing time of algorithms without increasing the overall cost.
The ropAe gene encodes a porin‐like protein involved in copper transit in Rhizobium etli CFN42

Copper (Cu) is an essential micronutrient for all aerobic forms of life. Its oxidation states (Cu+/Cu2+) make this metal an important cofactor of enzymes catalyzing redox reactions in essential biological processes. In gram‐negative bacteria, Cu uptake is an unexplored component of a finely regulated trafficking network, mediated by protein–protein interactions that deliver Cu to target proteins and efflux surplus metal to avoid toxicity. Rhizobium etliCFN42 is a facultative symbiotic diazotroph that must ensure its appropriate Cu supply for living either free in the soil or as an intracellular symbiont of leguminous plants. In crop fields, rhizobia have to contend with copper‐based fungicides. A detailed deletion analysis of the pRet42e (505 kb) plasmid from an R. etli mutant with enhanced CuCl2 tolerance led us to the identification of the ropAe gene, predicted to encode an outer membrane protein (OMP) with a β–barrel channel structure that may be involved in Cu transport. In support of this hypothesis, the functional characterization of ropAe revealed that: (I) gene disruption increased copper tolerance of the mutant, and its complementation with the wild‐type gene restored its wild‐type copper sensitivity; (II) the ropAe gene maintains a low basal transcription level in copper overload, but is upregulated when copper is scarce; (III) disruption of ropAe in an actP (copA) mutant background, defective in copper efflux, partially reduced its copper sensitivity phenotype. Finally, BLASTP comparisons and a maximum likelihood phylogenetic analysis highlight the diversification of four RopA paralogs in members of the Rhizobiaceae family. Orthologs of RopAe are highly conserved in the Rhizobiales order, poorly conserved in other alpha proteobacteria and phylogenetically unrelated to characterized porins involved in Cu or Mn uptake.
Learning with support vector machines for query-by-multiple-examples

We explore an alternative Information Retrieval paradigm called Query-By-Multiple-Examples (QBME) where the information need is described not by a set of terms but by a set of documents. Intuitive ideas for QBME include using the centroid of these documents or the well-known Rocchio algorithm to construct the query vector. We consider this problem from the perspective of text classification, and find that a better query vector can be obtained through learning with Support Vector Machines (SVMs). For online queries, we show how SVMs can be learned from one-class examples in linear time. For offline queries, we show how SVMs can be learned from positive and unlabeled examples together in linear or polynomial time. The effectiveness and efficiency of the proposed approaches have been confirmed by our experiments on four real-world datasets.
Induction motor speed control based on fuzzy model identification and model reference

This paper presents an algorithm of induction motor speed controlled, for nonlinear dynamic process of the motor speed, using fuzzy linear fitting method through the local subsets are connected to construct integrated system model. Based on the difference between the reference vector and the speed vector of the induction motor under fuzzy model identified, a variable structure control to modulate the motor speed is achieved, presented controller has robustness to the external disturbance and the system uncertainty, and the output speed of the motor can fast track the command speed. Simulation results show that the control plan is excellent.
Aufmerksamkeitsdefizit-/ Hyperaktivitätsstörungen bei Drei- bis Sechsjährigen in der ärztlichen Praxis - eine bundesweite Befragung

Zusammenfassung: Fragestellung: Ziel der Arbeit ist die Ermittlung der Pravalenzen von Symptomen und Diagnosen einer Aufmerksamkeitsdefizit- /Hyperaktivitatsstorung (ADHS) bei Kindern im Vorschulalter, die Erfassung der Funktionseinschrankungen und komorbider Symptome im Eltern- und Erzieherurteil. Methodik: Bundesweit nahmen 708 Kinder aus 103 padiatrischen oder kinder- und jugendpsychiatrischen Praxen teil. Verwendet wurden Fremdbeurteilungsbogen fur Hyperkinetische Storungen im Vorschulalter (FBB-ADHS-V) im Eltern- und Erzieherurteil, sowie arztliche Beurteilungen von n = 521 Kindern aus U8/U9 Vorsorgeuntersuchungen (U8/U9), oder vom Arzt als ADHS-auffallig eingeschatzte Kinder n = 187 (AUF) unter Ausschluss einer U8/U9-Vorsorgeuntersuchung. Ergebnisse: In U8/U9 erfullen im Elternurteil 11,3% der Kinder die Diagnosekriterien fur eine der drei ADHS-Diagnosen nach DSM-IV (ICD-10: 3,8%), im Erzieherurteil sind es nur 6,6% (ICD-10: 1,5). Bei Beurteilerubereinstimmung erfullen 4,2 % aller Kinder aus U8/U9 d.
Internet-based cognitive behaviour therapy and physical exercise - Effects studied by automated telephone assessments in mental ill-health patients; a randomized controlled trial.

OBJECTIVES Mental ill-health has become a large health problem and it is important for caregivers to provide effective treatment alternatives. REGASSA is a randomized controlled study performed in primary care to study the effects of 12 weeks of Internet-based cognitive behaviour therapy (ICBT) and physical exercise (PE) compared with treatment as usual (TAU) in patients with mild-to-moderate mental ill-health. The present study aimed to examine the results of these treatment alternatives on psychological functioning, stress, and sleep disturbances. METHODS The study comprised 879 patients with mental ill-health taking part in the REGASSA study. Data were collected by Interactive Voice Response (IVR), a computerized, automated telephone technique. The treatments were compared at baseline, twice during treatment, at the end of treatment and at three follow-ups after treatment. Measures used were the Outcome Questionnaire-45, the short versions of the Perceived Stress Scale, and the Karolinska Sleep Questionnaire. RESULTS Linear mixed models showed that the patients in ICBT and PE had better results than in TAU on psychological functioning and sleep disturbances, p < . 001, with weak-to-moderate effect sizes. On stress there were no differences; all groups made improvements. Women had stronger effects than men. More patients recovered on psychological functioning (OQ-45) in ICBT and PE than in TAU. CONCLUSIONS Internet-based cognitive behaviour therapy and PE proved to be effective treatment alternatives for patients with mild-to-moderate mental ill-health in improving psychological functioning, stress, and sleep disturbances and could be useful alternatives in primary care. PRACTITIONER POINTS Internet-based cognitive behaviour therapy and physical exercise proved to be effective treatment alternatives for mental ill-health patients in primary care. Automated techniques (Interactive Voice Response) could be useful for following treatment course in large groups of patients in the health care. It is important to use measures that capture different aspects of patients' health problems. The recruitment of participants was based on patients' interest and inclusion criteria which may have affect the generalizability.
Modelling heterogeneity in clustered count data with extra zeros using compound Poisson random effect

In medical and health studies, heterogeneities in clustered count data have been traditionally modeled by positive random effects in Poisson mixed models; however, excessive zeros often occur in clustered medical and health count data. In this paper, we consider a three‐level random effects zero‐inflated Poisson model for health‐care utilization data where data are clustered by both subjects and families. To accommodate zero and positive components in the count response compatibly, we model the subject level random effects by a compound Poisson distribution. Our model displays a variance components decomposition which clearly reflects the hierarchical structure of clustered data. A quasi‐likelihood approach has been developed in the estimation of our model. We illustrate the method with analysis of the health‐care utilization data. The performance of our method is also evaluated through simulation studies. Copyright © 2009 John Wiley & Sons, Ltd.
Universalism without foundations?

At a time when the notion of universal values is coming under attack from a variety of positions, Martha Nussbaum’s new book is a rigorously argued attempt to defend the ideal. Taking cognizance of many of the criticisms made of universalism, Nussbaum drafts a credo that tries not to be ‘blind to complexity’, as she concedes certain forms of ‘obtuse universalizing’ can be. Obtuse universalizing in Nussbaum’s words, characterizes mainstream theorizing about the global economy, for instance, assuming that people are simply rational agents in the global market, ignoring the role that traditions and context play in the construction of desire, and neglecting the many different conceptions of the good that citizens of different nations have. In an era of unbridled celebration of the liberatory potential of markets, Nussbaum’s is a refreshing corrective, attempting to reinstate the legitimacy of expectations of social responsibility from governments. The fact that some universal approaches are obtuse does not indict them all, urges Nussbaum. ‘Pluralism and respect for difference are themselves universal values that are not everywhere observed; they require a normative articulation and defence. ’ Such a defence is one of the goals of this project (p. 32). The  rst part of this article will explore the potential and limits of the theoretical argument provided by the book and the second part will take up Nussbaum’s application of the capabilities approach to two ‘problem areas’ in women’s lives – religion and the family in the Indian context. A  nal section examines some broader questions for democratic theory and practice that arise from this discussion.
Saliency and Segregation Without Feature Gradient: New Insights for Segmentation from Orientation-Defined Textures

The analysis of texture patterns, and texture segregation in particular, are at the heart of perceptual organization. In this paper we question the widely accepted view that the detection (both perceptual and computational) of salient perceptual singularities between perceptually coherent texture regions is tightly dependent upon feature gradients. Specifically, we study smooth orientation-defined textures (ODTs) and show that they exhibit striking perceptual singularities even without any outstanding gradients in their defining feature, namely orientation. We further show how these generic singularities are not only unpredictable from the orientation gradient, but that they also defy popular segmentation algorithms and neural models. We then examine smooth ODTs from a (differential) geometric point of view and develop a theory that fully predicts their perceptual singularities from two ODT curvatures. The computational results exhibit striking correspondence to segregation performed by human subjects and provide a conclusive evidence for the role of curvature in texture segregation. Extensions and implications of our results are developed for various aspects of visual processing.
Partial least squares analysis in developmental psychopathology

Abstract Despite extensive theoretical and empirical advances in the last two decades, little attention has been paid to the development of statistical techniques suited for the analysis of data gathered in studies of developmental psychopathology. As in most other studies of developmental processes, research in this area often involves complex constructs, such as intelligence and antisocial behavior, measured indirectly using multiple observed indicators. Relations between pairs of such constructs are sometimes reported in terms of latent variables (LVs): linear combinations of the indicators of each construct. We introduce the assumptions and procedures associated with one method for exploring these relations: partial least squares (PLS) analysis, which maximizes covariances between predictor and outcome LVs; its coefficients are correlations between observed variables and LVs, and its LVs are sums of observable variables weighted by these correlations. In the least squares logic of PLS, familiar notions about simple regressions and principal component analyses may be reinterpreted as rules for including or excluding particular blocks in a model and for “splitting” blocks into multiple dimensions. Guidelines for conducting PLS analyses and interpreting their results are provided using data from the Goteborg Daycare Study and the Seattle Longitudinal Prospective Study on Alcohol and Pregnancy. The major advantages of PLS analysis are that it (1) concisely summarizes the intercorrelations among a large number of variables regardless of sample size, (2) yields coefficients that are readily interpretable, and (3) provides straightforward decision rules about modeling. The advantages make PLS a highly desirable technique for use in longitudinal research on developmental psychopathology. The primer is written primarily for the nonstatistician, although formal mathematical details are provided in Appendix 1.
Vertical Security in the Megacity

By excavating the ambiguities of the helicopter’s machinic-prosthetic view, a perspective which may be distant and abstract, while also near and viscerally present, this article will explore how megacity security is increasingly waged and consumed. The article argues that megacity security marches to the rotator-beat of the police helicopter, fuelled by military technophilia and in a context of the biopolitical desertion of the megacities’ most vulnerable. The article takes three aspects, visually expressed and constituted through aerial-helicopter security. Drawing from several megacity examples including Mumbai, Lagos, São Paulo and Rio de Janeiro, the first resolves megacity confusion with legibility. In the following section the article examines the mobilization of the security gaze, and the final section explores how helicopter visuality may hold or territorialize megacity space.
Measuring Subjective and Objective Well-being: Analyses from Five Marine Commercial Fisheries

Well-being is an important indicator of how participants in an industry are doing. Since the 1970s, anthropologists have been developing and utilizing "well-being" as an indicator, along with identifying the advantages and disadvantages of such a metric. Building on this experience, a "well-being" index is useful if it (1) is easily developed from available data; (2) enables temporal and spatial comparisons; (3) can be applied at multiple scales; and (4) possesses subjective and objective elements. The subjective element reflects how individuals and members of occupational communities perceive their situation. Using five case studies of North American marine commercial fisheries, an approach to representing subjective and objective measures of well-being is illustrated and evaluated. These studies show that commercial fishing has historically been a highly valued occupation from both subjective and objective perspectives. However, the status of commercial fishing has been in a state of decline over the pa.
Using the past to score the present: extending term weighting models through revision history analysis

The generative process underlies many information retrieval models, notably statistical language models. Yet these models only examine one (current) version of the document, effectively ignoring the actual document generation process. We posit that a considerable amount of information is encoded in the document authoring process, and this information is complementary to the word occurrence statistics upon which most modern retrieval models are based. We propose a new term weighting model, Revision History Analysis (RHA), which uses the revision history of a document (e.g., the edit history of a page in Wikipedia) to redefine term frequency - a key indicator of document topic/relevance for many retrieval models and text processing tasks. We then apply RHA to document ranking by extending two state-of-the-art text retrieval models, namely, BM25 and the generative statistical language model (LM). To the best of our knowledge, our paper is the first attempt to directly incorporate document authoring history into retrieval models. Empirical results show that RHA provides consistent improvements for state-of-the-art retrieval models, using standard retrieval tasks and benchmarks.
The Professional and Organizational Socialization of New English Headteachers in School Reform Contexts

The headteacher's role in school improvement and the changing nature of the role suggest the need to investigate how new school leaders learn their jobs, that is, their socialization to the leader role. This study has two purposes: (1) to identify the content and methods used in the professional and organizational socialization experiences of new English headteachers; and (2) to examine how headteachers perceive that these socialization processes affect their roles as headteachers. The study is based on a longitudinal, multi-case study of primary headteachers during their second and third years. The study found that the new headteachers experience what they referred to as traumatic first-year experiences, which involved management issues. They also had to learn how to form important relationships and how to develop self-learning. This learning occurred through professional, organizational and personal socialization methods and reinforced the important role of mentors, teachers, deputies and former headteachers. The study reinforces the need to further examine how new school leaders learn their jobs in complex, reform environments.
Aberrant Epigenetic Silencing Is Triggered by a Transient Reduction in Gene Expression

Background Aberrant epigenetic silencing plays a major role in cancer formation by inactivating tumor suppressor genes. While the endpoints of aberrant silencing are known, i.e., promoter region DNA methylation and altered histone modifications, the triggers of silencing are not known. We used the tet-off system to test the hypothesis that a transient reduction in gene expression will sensitize a promoter to undergo epigenetic silencing. Methodology/Principal Findings The tet responsive promoter (PTRE) was used to drive expression of the selectable human HPRT cDNA in independent transfectants of an Hprt deficient mouse cell line. In this system, high basal HPRT expression is greatly reduced when doxycycline (Dox) is added to the culture medium. Exposure of the PTRE-HPRT transfectants to Dox induced HPRT deficient clones in a time dependent manner. A molecular analysis demonstrated promoter region DNA methylation, loss of histone modifications associated with expression (i.e., H3 lysine 9 and 14 acetylation and lysine 4 methylation), and acquisition of the repressive histone modification H3 lysine 9 methylation. These changes, which are consistent with aberrant epigenetic silencing, were not present in the Dox-treated cultures, with the exception of reduced H3 lysine 14 acetylation. Silenced alleles readily reactivated spontaneously or after treatment of cells with inhibitors of histone deacetylation and/or DNA methylation, but re-silencing of reactivated alleles did not require a new round of Dox exposure. Inhibition of histone deacetylation inhibited both the induction of silencing and re-silencing, whereas inhibition of DNA methylation had no such effect. Conclusions/Significance This study demonstrates that a transient reduction in gene expression triggers a pathway for aberrant silencing in mammalian cells and identifies histone deacetylation as a critical early step in this process. DNA methylation, in contrast, is a secondary step in the silencing pathway under study. A model to explain these observations is offered.