Miracle-dz/UniFAR-FTUs huggingface dataset:
Paradoxical effect of anthralin on 12-O-tetradecanoylphorbol-13-acetate-induced mouse epidermal ornithine decarboxylase activity, proliferation, and tumor promotion.

Anthralin, a weak promoter of mouse skin tumorigenesis, actually inhibits tumorigenesis when applied either before each promoting application of the potent tumor promoter, 12- O -tetradecanoylphorbol-13-acetate (TPA), or twice in the interval between initiation with 200 nmol 7,12-dimethylbenz(a)anthracene and the beginning of promotion with TPA (8.5 nmol for all tumor experiments). In tumor experiments, when 8.8 nmol anthralin were applied 2 hr prior to each twice-weekly promoting dose of TPA, the number of tumors per mouse was reduced by 20%; with 88 nmol anthralin, the number of tumors per mouse was reduced by 40 to 60%. If two applications of 88 nmol anthralin were given 2 hr prior to the first two promoting applications of TPA only, tumorigenesis was inhibited by 30%. However, if 88 nmol anthralin were applied once 1 week after initiation and once 1 week later and TPA promotion was begun 48 hr after the second dose, tumorigenesis was inhibited by 70%. In biochemical determinations, a single pretreatment with either dose of anthralin inhibited ornithine decarboxylase (ODC) activity induced by a single application of TPA by about 75% and [3H]thymidine incorporation into DNA by 20 and 60% for the 8.8-nmol and 88-nmol dose, respectively. After four repetitions of the anthralin plus TPA treatment at 2- to 3-day intervals, the 8.8-nmol anthralin pretreatment was without inhibitory effect on either ODC activity or DNA synthesis, while 88 nmol anthralin inhibited both activities by about 40%. Histologically, at either dose of anthralin, a single anthralin plus TPA treatment resulted in considerable epidermal destruction. Treatment with any of the chemicals alone did not cause such destruction, nor was destruction evident for either dose of anthralin after the fourth anthralin plus TPA treatment. Moreover, the skin of animals given anthralin between initiation and the first application of TPA did not show epidermal destruction. Since the animals in the previous experiment did not show epidermal destruction and since anthralin loses its ability to inhibit TPA-induced ODC activity when applied more than 24 hr before TPA, neither a generalized epidermal cytotoxicity nor an inhibition of TPA-induced ODC activity appears to totally explain the mechanism of anthralin-mediated inhibition of tumorigenesis. We have therefore suggested that immunological mechanisms may be a factor in our results.
Identifying and treating fluoropyrimidine-associated hand-and-foot syndrome in white and non-white patients.

The recent introduction of oral 5-FU analogs has permitted development of dosing regimens with pharmacokinetics similar to those of long IV infusions, but without the need for indwelling ve-nous access. Oral regimens provide improved con-venience and safety and are preferred by a major-ity of patients.
A composable, energy-managed, real-time MPSOC platform

Multi-processors systems on chip (MPSOC) platforms emerged in embedded systems as hardware solutions to support the continuously increasing functionality and performance demands in this domain. Such a platform has to execute a mix of applications with diverse performance and timing constraints, i.e., real-time or non-real-time, thus different application schedulers should co-exist on an MPSOC. Moreover, applications share many MPSOC resources, thus their timing depends on the arbitration at these resources. Arbitration may create inter-application dependencies, e.g., the timing of a low priority application depends on the timing of all higher priority ones. Application inter-dependencies make the functional and timing verification and the integration process harder. This is especially problematic for real-time applications, for which fulfilling the time-related constraints should be guaranteed by construction. Moreover, energy and power management, commonly employed in embedded systems, make this verification even more difficult. Typically, energy and power management involves scaling the resources operating point, which has a direct impact on the resource performance, thus influences the application time behaviour. Finally, a small change in one application leads to the need to re-verify all other applications, incurring a large effort. Composability is a property meant to ease the verification and integration process. A system is composable if the functionality and the timing behaviour of each application is independent of other applications mapped on the same platform. Composability is achieved by utilising arbiters that ensure applications independence. In this paper we present the concepts behind a composable, scalable, energy-managed MPSOC platform, able to support different real-time and nonreal time schedulers concurrently, and discuss its advantages and limitations.
A wearable in-ear encephalography sensor for monitoring sleep: preliminary observations from nap studies

Rationale: To date the only quantifiable measure of neural changes that define sleep is electroencephalography (EEG). Although widely used for clinical testing, scalp-electrode EEG is costly and poorly tolerated by sleeping patients. Objective: This is a pilot study to assess the agreement between EEG recordings obtained from a new ear-EEG sensor and those obtained simultaneously from standard scalp electrodes. Methods: Participants were 4 healthy men, ages 25 to 36 years. During naps, EEG tracings were recorded simultaneously from the ear sensor and standard scalp electrodes. A clinical expert, blinded to the data collection, analyzed 30-second epochs of recordings from both devices using standardized criteria. The agreement between scalp- and ear-recordings was assessed. Measurements and Main Results: We scored 360 epochs (scalp-EEG and ear-EEG) of which 254 (70.6%) were scored as non-rapid-eye movement (NREM) sleep using scalp-EEG. The ear-EEG sensor had a sensitivity of 0.88 (95% CI 0.82 to 0.92) and specificity of 0.78 (95% CI 0.70 to 0.84) in detecting N2/N3 sleep. The kappa coefficient, between the scalp- and ear-EEG, was 0.65 (95% CI 0.58 to 0.73). As a sleep monitor (all NREM sleep stages versus wake), the in-ear sensor had a sensitivity of 0.91 (95% CI 0.87 to 0.94) and specificity of 0.66 (95% CI 0.56 to 0.75). The kappa coefficient was 0.60 (95% CI 0.50 to 0.69). Conclusions: Substantial agreement was observed between recordings derived from a new ear-EEG sensor and conventional scalp electrodes on 4 healthy volunteers during daytime naps.
Epidemiologic analysis of injuries occurred during the 15th Brazilian Indoor Soccer (Futsal) Sub20 Team Selection Championship

Introduction: Several authors have investigated the incidence of injuries occurred in the outdoor soccer game. However, there are only few works analyzing injuries occurred in the indoor soccer game (futsal). The purpose of this study was to analyze the incidence, circumstances, and characteristics of injuries recorded in the indoor soccer during the 15 th Brazilian Sub20 Futsal Championship. Methods: Physiotherapists and doctors of every team selection participating in the 15 th Brazilian Sub20 Futsal Championship answered a questionnaire with the purpose to investigate the occurrence of injuries during the games. The answering rate was 100%. Results: 32 total injuries were recorded along 23 games, with a 1.39 injury incidence per game, or 208.6 injuries per 1,000/game. Approximately 1 to 3 injuries per game resulted in removal of players from gaming or training. Contact injuries were predominant in 65.62% (21 out of 32 injuries), and most of these injuries did not result in removal of the players. Conclusions: The present study observed that the injury incidence during the 15 th Brazilian Sub20 Futsal Championship was similar to the incidence during the Indoor Soccer tournaments, but higher than those found in the outdoor soccer tournaments, characterizing the specificity of the sports. Nevertheless, circumstances and characteristics are similar among them, mainly due to the similar demand of the sports.
SiGe transformer matched power amplifier for operation at millimeter-wave frequencies

In this paper, a transformer matched power amplifier for operation at millimeter-wave frequencies is presented. The SiGe single-stage push-pull amplifier uses a stacked transformer above a ground shield for output matching. The millimeter-wave transformer has a high coupling factor k = 0.8 and provides a very compact circuit layout. At 61.5 GHz the class-AB biased amplifier achieves a power gain of 12 dB with 8.5 dBm output power at a 1 dB compression. The saturated output power was measured up to P/sub sat/ = 14 dBm with a maximum PAE of 4.2%.
A Review of Smart House Analysis Methods for Assisting Older People Living Alone

Smart Houses are a prominent field of research referring to environments adapted to assist people in their everyday life. Older people and people with disabilities would benefit the most from the use of Smart Houses because they provide the opportunity for them to stay in their home for as long as possible. In this review, the developments achieved in the field of Smart Houses for the last 16 years are described. The concept of Smart Houses, the most used analysis methods, and current challenges in Smart Houses are presented. A brief introduction of the analysis methods is given, and their implementation is also reported.
2017 Year in Review

The Journal of Applied Gerontology (JAG) had an eventful 2017, with another leap in impact factor and a smooth transition in Editorial leadership. Joseph Gaugler stepped down as Editor-in-Chief in September, after serving 6 years at the helm. We owe JAG’s steady climb in stature and influence to Joe’s diligent work, with excellent assistance in recent years from Managing Editor KjerstieWiltzen. My heartfelt thank yous go to Joe and Kjerstie for their patience and support through the transition process. Our new Managing Editor, Kaleigh Ligus, has quickly mastered myriad JAG processes and we are off and running! We have received warm welcomes from members of the Editorial Board, who have diligently served as reviewers and advisors throughout 2017. We also have excellent support from the SAGE publications team, notably Jessica Lipowski, Judy Connors, Leann Zurmuhlen, and Lauren Hunt, to keep us moving forward. The Southern Gerontological Society Executive and Publications Committees continue to offer substantial guidance as well. And finally, thank you to Southern Gerontological Society members in general, as well as to all of JAG’s reviewers, for their commitment to the scholarly excellence of the journal.
OCTOPUS-a scalable global multiparty video conferencing system

This paper reports a joint work between the Hong Kong University of Science and Technology and the Brandenburg Technical University of Cottbus, Germany, in developing a global video conferencing framework called OCTOPUS that interconnects local conferencing systems over long distances. The system makes use of both high level information provided by the participants (to decide which videos are more important to them) as well as low level adaptive mechanisms to perform media scaling as the network and the processor intensities change. It is possible to provide a customized service to each conference participant according to his/her needs and the resources available at each site. OCTOPUS itself makes no assumption on the architecture of the local video conference systems. The paper presents the architecture and the design philosophy of the OCTOPUS framework.
The Orphan Nuclear Receptor Ear-2 Is a Negative Coregulator for Thyroid Hormone Nuclear Receptor Function

ABSTRACT Thyroid hormone (T3) nuclear receptors (TR) are ligand-dependent transcription factors which regulate growth, differentiation, and development. One emerging hypothesis suggests that TR mediate these diverse effects via a large network of coregulators. Recently, we found that TR-mediated transcriptional responses varied in six cell lines derived from different tissues. We therefore used human TR subtype β1 (TRβ1) as bait to search for coregulators in human colon carcinoma RKO cells with a yeast two-hybrid system. RKO cells exhibited T3-dependent and -independent transcriptional activation. One of the three positive clones was identified as Ear-2, which is a distant member of the chick ovalbumin upstream promoter-transcription factors of the orphan nuclear receptor family. The physical interaction between Ear-2 and TRβ1 was further confirmed by specific binding of Ear-2 to glutathione S-transferase–TRβ1. In addition, Ear-2 was found to associate with TRβ1 in cells. As a result of this physical interaction, binding of TRβ1 to the T3 response elements was inhibited. Using reporter systems, we found that both the basal activation and the T3-dependent activation mediated by TRβ1 were repressed by Ear-2 in CV1 cells. In RKO cells, however, the T3-independent transcriptional activity was more sensitive to the repression effect of Ear-2 than the T3-dependent transcriptional activity. The repression effect of Ear-2 was reversed by steroid hormone receptor coactivator 1. These results suggest that TR-mediated responses reflect a balance of corepressors and coactivators in cells. These findings further strengthen the hypothesis that the diverse activities of TR are achieved via a large network of coregulators that includes Ear-2.
SemSearch'11: the 4th semantic search workshop

The use of semantics and semantic technologies for search and retrieval has attracted interests both from academia and industry in recent years. What is now commonly known as Semantic Search is in fact a broad field encompassing ideas and concepts from different areas, including Information Retrieval, Semantic Web and database. This is the fourth edition of the Semantic Search workshop which aims to bring together researchers and practitioners from various communities, to provide a forum for dissemination, discussion, and for the exchange and transfer of knowledge related to the use of semantics for search and retrieval. This year's workshop will continue to push and promote efforts towards an evaluation benchmark for Semantic Search systems.
Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease

Objective: To investigate factors, including cognitive and brain reserve, which may independently predict prevalent and incident dementia of the Alzheimer type (DAT) and to determine whether inclusion of identified factors increases the predictive accuracy of the CSF biomarkers Aβ42, tau, ptau181, tau/Aβ42, and ptau181/Aβ42. Methods: Logistic regression identified variables that predicted prevalent DAT when considered together with each CSF biomarker in a cross-sectional sample of 201 participants with normal cognition and 46 with DAT. The area under the receiver operating characteristic curve (AUC) from the resulting model was compared with the AUC generated using the biomarker alone. In a second sample with normal cognition at baseline and longitudinal data available (n = 213), Cox proportional hazards models identified variables that predicted incident DAT together with each biomarker, and the models' concordance probability estimate (CPE), which was compared to the CPE generated using the biomarker alone. Results: APOE genotype including an ε4 allele, male gender, and smaller normalized whole brain volumes (nWBV) were cross-sectionally associated with DAT when considered together with every biomarker. In the longitudinal sample (mean follow-up = 3.2 years), 14 participants (6.6%) developed DAT. Older age predicted a faster time to DAT in every model, and greater education predicted a slower time in 4 of 5 models. Inclusion of ancillary variables resulted in better cross-sectional prediction of DAT for all biomarkers (p < 0.0021), and better longitudinal prediction for 4 of 5 biomarkers (p < 0.0022). Conclusions: The predictive accuracy of CSF biomarkers is improved by including age, education, and nWBV in analyses.
Adaptive prefetching scheme for exploiting massive memory bandwidth of 3-D IC technology

Three-dimensional (3-D) integration technology dramatically increases the memory bandwidth by stacking memory directly on the top of a processor. This paper proposes a stream buffer based adaptive prefetching scheme to exploit the massive memory bandwidth provided by 3-D integration technology. Performance simulation results show that the proposed stream buffer based adaptive prefetching scheme with a 16KB cache can achieve the performance improvement over the L2 cache with the capacity of 256KB and 512KB about 15% and 14% respectively.
Functionalized nanocompartments (Synthosomes): Limitations and prospective applications in industrial biotechnology

Synthosomes are mechanically stable vesicles with a block copolymer membrane and an engineered transmembrane protein acting as selective gate. The polymer vesicles are nanometer‐sized (50‐1000 nm) and functionalized by loading them with enzymes for bioconversions or encapsulating charged macromolecules for selective compound recovery/release. The Synthosome system might become a novel technology platform for biocatalysis and selective product recovery. Progress in Synthosome research comprises employed block copolymers, transmembrane channel engineering, and functionalizations, which are discussed here in detail. The challenges in transmembrane protein engineering, as well as cost‐effective production, in block copolymer design and the state of the art in Synthosome characterization comprising quantification of encapsulated protein, translocation efficiency, number of transmembrane channels per vesicle, and enzyme kinetics are also presented and discussed. An assessment of the Synthosome technology platform for prospective applications in industrial (white) biotechnology concludes this review.
Role of NF- (cid:2) B in Cell Survival and Transcription of Latent Membrane Protein 1-Expressing or Epstein-Barr Virus Latency III-Infected Cells

Epstein-Barr virus (EBV) latency III infection converts B lymphocytes into lymphoblastoid cell lines (LCLs) by expressing EBV nuclear and membrane proteins, EBNAs, and latent membrane proteins (LMPs), which regulate transcription through Notch and tumor necrosis factor receptor pathways. The role of NF- (cid:1) B in LMP1 and overall EBV latency III transcriptional effects was investigated by treating LCLs with BAY11-7082 (BAY11). BAY11 rapidly and irreversibly inhibited NF- (cid:1) B, decreased mitochondrial membrane potential, induced apoptosis, and altered LCL gene expression. BAY11 effects were similar to those of an NF- (cid:1) B inhibitor, (cid:2) N-I (cid:1) B (cid:3) , in effecting decreased JNK1 expression and in microarray analyses. More than 80% of array elements that decreased with (cid:2) N-I (cid:1) B (cid:3) expression decreased with BAY11 treatment. Newly identiﬁed NF-
Measuring bodily responses to virtual faces with a pressure sensitive chair

The present aim was to study emotion related body movement responses using an unobtrusive measurement chair that is embedded with electromechanical film (EMFi) sensors. 30 participants viewed images of a male and a female computer agent while the magnitude and direction of body movements were measured. The facial expressions (i.e., frowning, neutral, smiling) and the size of the agents were varied. The results showed that participants leaned statistically significantly longer towards the agent when it displayed a frowning or a smiling expression as compared to a neutral expression. Also, their body movements were reduced while viewing the agents. The results suggest that the EMFi chair is a promising tool for detecting human activity related to social and emotional behaviour. In particular, the EMFi chair may support unobtrusive measurement of bodily responses in less strictly controlled contexts of human-computer interaction.
Locomotor activity and a conditioned fear response: correlation with cortical and subcortical binding of the dopamine D1 receptor antagonist [3H]SCH 23390

Rat behavior in the open field and conditioned fear response test was correlated with specific binding of dopamine D1 receptor antagonist [3H]SCH 23390 within different brain structures assayed with autoradiography. A significant positive correlation was found between the ligand binding in the substantia nigra pars reticulata and both animal motor activity (r = 0.67, p < 0.05) and the number of entries into the central sector of the open field (r = 0.59, p < 0.05). On the other hand, rat motility and the central entries were negatively correlated with [3H]SCH 23390 binding within the caudate putamen (r = −0.64, p < 0.05 and r = −0.61 p < 0.05, respectively). No correlation was revealed between the ligand binding in the examined brain areas and freezing reaction in the contextual fear conditioning test. The present data indicate for the first time a significant, structure-dependent correlation between rat motor behavior and the dopamine D1 receptor ligand binding within the nigrostriatal system.
Competencies Within a Professional Clinical Ladder: Differences in Understanding Between Nurse Managers and Staff Nurses

Clinical ladders provide a framework for professional nursing development and have shown increased personal and professional satisfaction. This article describes a standardized approach for clinical ladder implementation. Managers’ and staff nurses’ knowledge of the model must align for important stakeholders to perceive the clinical ladder as valuable. Understanding differences and perspectives can be useful as the basis for education and further clinical ladder refinement augmenting the potential for increased nursing satisfaction and professional development.
Short-Sequence DNA Repeats in Prokaryotic Genomes

SUMMARY Short-sequence DNA repeat (SSR) loci can be identified in all eukaryotic and many prokaryotic genomes. These loci harbor short or long stretches of repeated nucleotide sequence motifs. DNA sequence motifs in a single locus can be identical and/or heterogeneous. SSRs are encountered in many different branches of the prokaryote kingdom. They are found in genes encoding products as diverse as microbial surface components recognizing adhesive matrix molecules and specific bacterial virulence factors such as lipopolysaccharide-modifying enzymes or adhesins. SSRs enable genetic and consequently phenotypic flexibility. SSRs function at various levels of gene expression regulation. Variations in the number of repeat units per locus or changes in the nature of the individual repeat sequences may result from recombination processes or polymerase inadequacy such as slipped-strand mispairing (SSM), either alone or in combination with DNA repair deficiencies. These rather complex phenomena can occur with relative ease, with SSM approaching a frequency of 10−4 per bacterial cell division and allowing high-frequency genetic switching. Bacteria use this random strategy to adapt their genetic repertoire in response to selective environmental pressure. SSR-mediated variation has important implications for bacterial pathogenesis and evolutionary fitness. Molecular analysis of changes in SSRs allows epidemiological studies on the spread of pathogenic bacteria. The occurrence, evolution and function of SSRs, and the molecular methods used to analyze them are discussed in the context of responsiveness to environmental factors, bacterial pathogenicity, epidemiology, and the availability of full-genome sequences for increasing numbers of microorganisms, especially those that are medically relevant.