Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling contribution for virtual enterprise support

The design or the realization of any project implies the involvement of a set of agents that can be individuals, teams or enterprises. These agents share resources and competencies, similar or dissimilar, and cooperate in order to reach some shared objectives by using Information Technologies. We speak then about virtual enterprises. However, exchanging data is not sufficient to support virtual enterprises, it is necessary to develop some adequate tools to guarantee a smooth functioning. Within a methodological framework for the design of inter-enterprise cooperation systems particularly in the field of virtual enterprises, we present in this paper three models of integration by data, by processes and by knowledge to support communication, coordination and collective problem-solving. We conclude this paper with a brief early evaluation of the advantages of our approach for inter-enterprise cooperation, by comparison with existing work coordination tools and architectures.
The role of tumor necrosis factor receptor superfamily members in mammalian brain development, function and homeostasis

Abstract Tumor necrosis factor receptor superfamily (TNFRSF) members were initially identified as immunological mediators, and are still commonly perceived as immunological molecules. However, our understanding of the diversity of TNFRSF members’ roles in mammalian physiology has grown significantly since the first discovery of TNFRp55 (TNFRSF1) in 1975. In particular, the last decade has provided evidence for important roles in brain development, function and the emergent field of neuronal homeostasis. Recent evidence suggests that TNFRSF members are expressed in an overlapping regulated pattern during neuronal development, participating in the regulation of neuronal expansion, growth, differentiation and regional pattern development. This review examines evidence for non-immunological roles of TNFRSF members in brain development, function and maintenance under normal physiological conditions. In addition, several aspects of brain function during inflammation will also be described, when illuminating and relevant to the non-immunological role of TNFRSF members. Finally, key questions in the field will be outlined.
Control as an Industrie 4.0 component: Network-adaptive applications for control

The industry is evolving towards a future of smart factories, aided by initiatives like Factories of the Future, Digital Factory and Industrie 4.0. The enabling technologies of this evolution are Industrial Internet of Things, Cyber-Physical Systems and Plug-and-Produce, among others. This paper discusses the idea of a control application following the philosophy of Industrie 4.0 components, and taking advantage of recent research on reliable control schemas. The aim is a control application that is deployable on different platforms, including cloud based, and that is aware of its environment, i.e. computing power, memory, network, etc. This control application will be able to adapt flexibly to given resource and connectivity conditions by shaping its control value matrix, reacting in runtime to changes in the environment.
Ramsay Hunt Syndrome with Multiple Cranial Neuropathy in an Human Immunodeficiency Virus (HIV) Patient

Patient: Male, 29 Final Diagnosis: Ramsay Hunt syndrome with multiple cranial nerve involvement Symptoms: Chest pain • dizziness • dysesthesia • dysphagia • ear pain • facial palsy • gait imbalance • headache • vertigo Medication: Emtricitabine/tenofovir alafenamide and dolutegravir Clinical Procedure: — Specialty: Neurology Objective: Unusual clinical course Background: Ramsay Hunt syndrome is a rare otologic complication resulting from varicella zoster virus reactivation that can present with a myriad of clinical presentations. Most common being triad of ear pain, vesicles at auricle, and ear canal with same side facial palsy. Case Report: We report a case of a 29-year-old male with a human immunodeficiency virus (HIV) infection who presented with left facial palsy, vesicles, pain in the left ear, dysphagia, dizziness, and headache resulting from multiple cranial nerves involvement such as cranial nerve V, VII, VIII, IX, and X. Conclusions: This case report raises awareness among general practitioners to investigate for Ramsay Hunt syndrome in HIV patients presenting with ear pain with a thorough neurological exam and emphasize on the interplay of different specialties in managing these patients.
Use of Microsatellite Markers and Gene Dosage To Quantify Gene Copy Numbers in Candida albicans

ABSTRACT With microsatellite marker typing, the number of alleles must be known for calculation of allelic frequencies in the diploid Candida albicans for a given locus. We describe a gene dosage with a double real-time PCR. Such a dosage should also be useful in exploring the loss of heterozygosity in C. albicans.
Mesp1‐nonexpressing cells contribute to the ventricular cardiac conduction system

Previous fate mapping analysis, using Cre recombinase driven by the Mesp1 locus, revealed that Mesp1 is expressed in almost all of the precursors of the cardiovascular system, including the endothelium, endocardium, myocardium, and epicardium. Mesp1‐nonexpressing cells were found to be restricted to the outflow tract cushion and along the interventricular septum (IVS), which is a location that is suggestive of specialized cardiac conduction system (CCS). In our current study, we examined the identity of these IVS cells by using the pattern of β‐galactosidase activity in CCS‐lacZ mice. In addition, by crossing Mesp1‐Cre and floxed GFP reporter mice with CCS‐lacZ mice, we have calculated that approximately 20% of the ventricular CCS within the IVS corresponds to Mesp1‐nonexpressing cells. These data suggest that the ventricular CCS is of heterocellular origin. Furthermore, we indicate a possibility that a population of the cells that contribute to the ventricular CCS might be distinguished at an early stage of development. Developmental Dynamics 235:395–402, 2006. © 2005 Wiley‐Liss, Inc.
Annotating single amino acid polymorphisms in the UniProt/Swiss‐Prot knowledgebase

UniProtKB/Swiss‐Prot (http://beta.uniprot.org/uniprot; last accessed: 19 October 2007) is a manually curated knowledgebase providing information on protein sequences and functional annotation. It is part of the Universal Protein Resource (UniProt). The knowledgebase currently records a total of 32,282 single amino acid polymorphisms (SAPs) touching 6,086 human proteins (Release 53.2, 26 June 2007). Nearly all SAPs are derived from literature reports using strict inclusion criteria. For each SAP, the knowledgebase provides, apart from the position of the mutation and the resulting change in amino acid, information on the effects of SAPs on protein structure and function, as well as their potential involvement in diseases. Presently, there are 16,043 disease‐related SAPs, 14,266 polymorphisms, and 1,973 unclassified variants recorded in UniProtKB/Swiss‐Prot. Relevant information on SAPs can be found in various sections of a UniProtKB/Swiss‐Prot entry. In addition to these, cross‐references to human disease databases as well as other gene‐specific databases, are being added regularly. In 2003, the Swiss‐Prot variant pages were created to provide a concise view of the information related to the SAPs recorded in the knowledgebase. When compared to the information on missense variants listed in other mutation databases, UniProtKB/Swiss‐Prot further records information on direct protein sequencing and characterization including posttranslational modifications (PTMs). The direct links to the Online Mendelian Inheritance in Man (OMIM) database entries further enhance the integration of phenotype information with data at protein level. In this regard, SAP information in UniProtKB/Swiss‐Prot complements nicely those existing in genomic and phenotypic databases, and is valuable for the understanding of SAPs and diseases. Hum Mutat 29(3), 361–366, 2008. © 2008 Wiley‐Liss, Inc.
Identification of XcpZ Domains Required for Assembly of the Secreton of Pseudomonas aeruginosa

ABSTRACT Most of the exoproteins secreted by Pseudomonas aeruginosa are transported via the type II secretion system. This machinery, which is widely conserved in gram-negative bacteria, consists of 12 Xcp proteins organized as a multiprotein complex, also called the secreton. We previously reported that the mutual stabilization of XcpZ and XcpY plays an important role in the assembly of the secreton. In this study, we engineered variant XcpZ proteins by using linker insertion mutagenesis. We identified three distinct regions of XcpZ required for both the stabilization of XcpY and the functionality of the secreton. Interestingly, we also demonstrated that another component of the machinery, XcpP, can modulate the stabilizing activity of XcpZ on XcpY.
Novel Wide-Range Quantitative Nested Real-Time PCR Assay for Mycobacterium tuberculosis DNA: Development and Methodology

ABSTRACT Previously, we designed an internally controlled quantitative nested real-time (QNRT) PCR assay for Mycobacterium tuberculosis DNA in order to rapidly diagnose tuberculous meningitis. This technique combined the high sensitivity of nested PCR with the accurate quantification of real-time PCR. In this study, we attempted to improve the original QNRT-PCR assay and newly developed the wide-range QNRT-PCR (WR-QNRT-PCR) assay, which is more accurate and has a wider detection range. For use as an internal-control “calibrator” to measure the copy number of M. tuberculosis DNA, an original new-mutation plasmid (NM-plasmid) was developed. It had artificial random nucleotides in five regions annealing specific primers and probes. The NM-plasmid demonstrated statistically uniform amplifications (F = 1.086, P = 0.774) against a range (1 to 105) of copy numbers of mimic M. tuberculosis DNA and was regarded as appropriate for use as a new internal control in the WR-QNRT-PSR assay. In addition, by the optimization of assay conditions in WR-QNRT-PCR, two-step amplification of target DNA was completely consistent with the standard curve of this assay. Due to the development of the NM-plasmid as the new internal control, significantly improved quantitative accuracy and a wider detection range were realized with the WR-QNRT-PCR assay. In the next study, we will try to use this novel assay method with actual clinical samples and examine its clinical usefulness.
The Hyperactivity/Inattention Subscale of the Strengths and Difficulties Questionnaire Predicts Short- and Long-Term Weight Loss in Overweight Children and Adolescents Treated as Outpatients

Objective: The success of treatment for pediatric obesity is variable and often unsatisfactory. This study elucidates the influence of inattention and hyperactivity/impulsivity on short- and long-term weight loss and maintenance after outpatient treatment. Methods: We included 8- to 16-year-old overweight and obese participants treated in 17 multidisciplinary outpatient treatment centers in a nationwide observational study. All treatment centers that reported long-term (1-year) follow-up weight data of at least 60% of the participants were included. At the beginning and end of treatment and at 1 year follow-up weight and height were measured at the center. Inattention and hyperactivity/impulsivity were assessed with the hyperactivity/inattention subscale (HI) of the parent-rated Strengths and Difficulty Questionnaire (SDQ). General linear models were used with the standard deviation scores of the BMI (BMI-SDS) as dependent variable and HI scores as main independent variable adjusting for age, sex, baseline BMI-SDS, and center. Results: 394 participants were included (57% female, age: 11.7± 2.0 years, baseline BMI-SDS 2.32 ±.46 kg/m2). HI scores were significantly associated with short- and long-term BMI-SDS (p < 0.0005), with higher baseline HI scores predicting less weight loss. Conclusions: Our results indicate that inattention and hyperactivity/impulsivity are linearly associated with reduced short- and long-term weight loss. Implications for treatment are discussed.
Analysis of Voice Stress in Call Centers 183 ISCA

This paper presents how voice stress is manifested in the acoustic and phonetic structure of the speech signal. Out of few thousand authentic Police 997 emergency phone calls, a few hundred were selected automatically according to their duration (dialogs shorter than 3-4 seconds were omitted). Finally, 45 speakers were chosen for acoustic evaluation, the basis for selection being a perceptual assessment. Basic statistical measurements for stressed and neutral speech run over the database showed the relevance of the arousal dimension in stress processing. The MDVP analysis confirmed statistical significance of such parameters as fundamental frequency and pitch variation, noise-to harmonic-ratio, subharmonics and voice irregularities for stress detection. In case of highly stressful conditions a systematic over-one-octave shift in pitch was observed. Linear Discriminant Analysis based on 9 acoustic features showed it is possible to categorize the following classes: male – stressed and neutral, female stressed and neutral speech.
Lipid production by Yarrowia lipolytica for biofuels

M. N. C. Harder; A. S. Delabio; S. Cazassa; R. R. Remedio; J. A. Pires; T. R. R. Monteiro and V. Arthur 1 CENA/USP – Center of Nuclear Energy in Agriculture, Department of Radiobiology and Environment, University of Sao Paulo, Av. Centenario, 303, 13.400-000 Piracicaba, Brazil 2 FATEC Piracicaba, Department of Agroindustry, Technology College of Piracicaba, Av. Diacono Jair de Oliveira 651, 13.414-155 Piracicaba, Brazil 3 FATEC Piracicaba, Department of Biofuel, Technology College of Piracicaba, Av. Diacono Jair de Oliveira 651, 13.414-155 Piracicaba, Brazil 4 CENA/USP – Center of Nuclear Energy in Agriculture, Department of Ecology, University of Sao Paulo, Av. Centenario, 303, 13.400-000 Piracicaba, Brazil
The Generalized wH Value

In this note, we generalize the wHSh value [1] 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003300380034003900370030003300370034000000 [2] 08D0C9EA79F9BACE118C8200AA004BA90B02000000080000000E0000005F005200650066003300380034003900370030003300370036000000 for CO values.
Salmonella infection in ruptured abdominal aortic aneurysm.

NORMAL large elastic arteries are remarkably resistant to infection. 1,2 However, when congenital or acquired vascular abnormalities exist, this resistance may be compromised. For some unknown reason, enteric pathogens demonstrate a predilection for invasion of such abnormal vessels and members of the Salmonella group in particular are the most frequent offenders. Areas of arteriosclerotic change within large vessels are the usual site of bacterial invasion and aneurysmal rupture is the usual outcome. Prior to the advent of reconstructive vascular surgery, the ruptured abdominal aneurysm was largely a curiosity of academic interest. As vascular surgery was introduced it soon became apparent that infection was probably the gravest complication associated with reconstructive procedures. When infection exists prior to surgery, the chance of success is remote unless the infectious process can be eradicated. This report is prompted by a recent experience with a ruptured arteriosclerotic abdominal aortic aneurysm associated with salmonellosis. A review
Overexpression of signal transducer and activator of transcription (STAT-3 and STAT-5) transcription factors and alteration of suppressor of cytokine signaling (SOCS-1) protein in prostate cancer

Background: Prostate cancer is a leading cause of mortality in men worldwide especially in developing countries like India. The molecular mechanisms of the oncogenic signaling pathway(s) that are involved in prostate carcinogenesis play a crucial role in disease progression and persistence. There is an important role of signal transducer and activator of transcriptions (STATs) particularly STAT-3 and STAT-5 and its negative regulator suppressor of cytokine signaling-1 (SOCS-1). Methods: In the present study, the expression and localization of STAT and SOCS-1 proteins in prostate cancer by immunohistochemistry in a total of 150 formalin-fixed, paraffin-embedded human prostate tissues of different grade obtained by radical prostatectomies or transurethral resection. Results: A significantly strong STAT-3 expression pattern in 68% (65/95) prostate cancer cases as compared to 12% (5/55) in benign prostatic hyperplasia (BPH) controls (P < 0.001) was observed. Interestingly the SOCS-1 expression was found to be significantly elevated in prostate cancer cases (P < 0.001). Conclusions: The present study demonstrates overexpression of STAT-3 and STAT-5 proteins and a contrasting role of SOCS-1 in prostate cancer. These results suggest a critical association between altered expression of STAT-3 and STAT-5 with SOCS-1 and indicate its potential role as a negative regulator independent of JAK-STAT pathway in tumorigenic transformation of prostate tissue. The results of the present report focuses on the fundamental differences in major oncogenic signaling cascades between benign and malignant form of prostate tissue that plays a crucial role in prostate cancer biology.
Testing inheritance hierarchies in the ClassBench framework

Inheritance is a feature of the feature-oriented paradigm that permits substantial reuse of code. For us to have confidence in reused code, it must be adequately tested. Whilst object-oriented analysis, design and implementation techniques have received much attention in recent literature, object-oriented testing has been given comparatively little consideration. This paper presents an adaptation of the ClassBench methodology to the testing of inheritance hierarchies in C++. A small case study which applies the strategy to an inheritance hierarchy of a commercial class library is presented.
Expressing Speaker's Intentions through Sentence-Final Intonations for Japanese Conversational Speech Synthesis

In this study, we investigated speaker’s intentions that the listeners perceive through subtly different sentence-ﬁnal intonations. Approximately 2,000 sentence utterances were recorded and the fundamental frequency (F0) contours at the last vowel of those sentences were classiﬁed through one of the standard clustering algorithms. There found various F0 contours, namely, not only simple rising and falling intonations but also rise-fall and fall-rise intonations. In order to reveal the relationship between the intonation and the intentions, 10 representative contours were selected on the basis of the results of the clustering. Using the selected contours, a subjective evaluation was conducted. Six Japanese sentences that could have different meanings according to the sentence-ﬁnal intonations were synthesized and the F0 contour at the last vowel of each sentence was replaced with the contours. The results of the evaluation by nine listeners showed that, for example, a certain falling intonation could express the intention of the “conviction” and another one that slightly differ in the shape could convey “doubt. ” It was found that the subtle difference in the sentence-ﬁnal F0 shape conveyed various nuances and connotations.
Control and performance of a single-phase dual active half bridge converter based on 15kV SiC IGBT and 1200V SiC MOSFET

A single-phase Dual Active Half Bridge (DAHB) DC-DC converter topology is evaluated for medium voltage (MV) application. A 15kV SiC-IGBT based three-level half-bridge is connected to the high voltage (HV) primary side of a high frequency (HF) transformer operating at 10kHz link-frequency. A 1200V SiC-MOSFET based two-level H-bridge is connected on the low voltage (LV) secondary side. This topology requires fewer switches and is suitable for MV application particularly with high step-down ratio where HF transformer may have considerable parasitics. It offers advantage of half blocking voltage requirement per device on the HV side and a simpler transformer saturation protection implementation. This paper also presents a robust D-Q based inner current control technique for the single phase DAB. The converters on both HV and LV side of the DAHB, can also be switched in 60° zero quasi-square mode to eliminate 3rd harmonic voltage. The square and 60° modes of operation are compared. The DAHB converter topology and controls are validated with simulation results followed by experimental results.
The reproductive health indices and sex hormone levels in middle-aged and elderly Chinese men

Abstract Objective: The aim of this study was to analyze the age-related recession trajectory of reproductive health indices in middle-aged and elderly Chinese men. Methods: A population-based cross-sectional study was conducted in Jiashan County, Zhejiang in 2012. Healthy men between 40 and 80 years of age were considered eligible for the study. Physical examination and the sex hormones were measured. The subjects were assessed based on the 5-item version of the International Index of Erectile Function (IIEF-5) for Erectile Dysfunction (ED), and Aging Males’ Symptoms (AMS) scale for Symptomatic Late-Onset Hypogonadism (SLOH). Results: TG showed a decrease at age 60 years. Testis volume and TT did not show significant difference among the four age groups; cFT began to decrease at age 50 years and Bio-T decreased faster at age 50 years. SHBG and LH increased faster at age 50 and 70 years, respectively. IIEF5 score decrease faster at age 60 years. AMS scores increased faster at age 70 years. With the increase in age, the symptoms of ED and SLOH became severer. Conclusion: Different indices on reproductive health of men showed turning points at different ages. At first, androgenic sex hormones decreased faster, and then erectile dysfunction got severer, and the last overall male syndromes declined.
All (k;g)‐cages are k‐edge‐connected

A (k;g)‐cage is a k‐regular graph with girth g and with the least possible number of vertices. In this paper, we prove that (k;g)‐cages are k‐edge‐connected if g is even. Earlier, Wang, Xu, and Wang proved that (k;g)‐cages are k‐edge‐connected if g is odd. Combining our results, we conclude that the (k;g)‐cages are k‐edge‐connected. © 2005 Wiley Periodicals, Inc. J Graph Theory 48: 219–227, 2005
Harmoniser politiques sociale et environnementale : évaluation de l'impact d'une réhabilitation de quartiers défavorisés sur les émissions de CO2 liées aux déplacements

Cet article s'interesse a l'impact environnemental, mesure en termes d'emissions de CO2 d'un projet de reamenagement des quartiers du Mas du Taureau et du Pre de l'Herpe dans la banlieue nord de Lyon (Vaulx-en-Velin). Son objectif est de tester l'impact des relocalisations residentielles liees a une politique de mixite sociale sur les emissions de CO2 liees a la mobilite quotidienne des habitants a differentes echelles. A l'echelle de l'agglomeration, les emissions associees a la mobilite locale augmentent avec le revenu du menage et l'eloignement du centre (en lien avec la croissance du taux de motorisation et des distances parcourues quotidiennement). A l'echelle du quartier, la recherche d'une meilleure mixite sociale conduit a une augmentation de l'emission mobilite locale: elle passerait de 0,515 tonnes a 0,74 tonnes par an et par personne. Enfin, suivant l'orientation des migrations residentielles, l'emission mobilite des populations concernees peut baisser (cas d'une reconcentration des populations, avec un passage de 0,81 a 0,648 tonnes/pers/an.), comme elle peut augmenter (cas d'une migration tournee vers l'etalement urbain avec une augmentation de 0,515 a 0,822 tonnes). ------------------ " Cette publication vous est proposee avec l'aimable autorisation des auteurs et de l'editeur ".