Miracle-dz/UniFAR-FTUs huggingface dataset:
On the Currency of Egalitarian Justice

In his Tanner Lecture of 1979 called “Equality of What? ” Amartya Sen asked what metric egalitarians should use to establish the extent to which their ideal is realized in a given society. What aspect(s) of a person’s condition should count in a fundamental way for egalitarians, and not merely as cause of or evidence of or proxy for what they regard as fundamental? In this study I examine answers to that question, and discussions bearing on that question, in recent philosophical literature. I take for granted that there is something which justice requires people to have equal amounts of, not no matter what, but to whatever extent is allowed by values which compete with distributive equality; and I study what a number of authors who share that egalitarian view have said about the dimension(s) or respect(s) in which people should be made more equal, when the price in other values of moving toward greater equality is not intolerable. I also advance an answer of my own to Sen’s question. My answer is the product of an immanent critique of Ronald Dworkin, one, that is, which rejects Dworkin’s declared position because it is not congruent with its own underlying motivation. My response to Dworkin has been influenced by Richard Arneson’s work in advocacy of “equality of opportunity for welfare,” but my answer to Sen’s question is not that Arnesonian one, nor is my answer as well formulated as Arneson’s is.1 It needs much further refinement, but I nevertheless present it here, in a rough-and-ready form, because of its association with relatively fi nished criticisms of others which I think are telling. If this study contributes to understanding, it does so more because of those criticisms than because of the positive doctrine it affi rms.
Non‐Colinear Polyketide Biosynthesis in the Aureothin and Neoaureothin Pathways: An Evolutionary Perspective

Aureothin and neoaureothin (spectinabilin) represent rare nitroaryl‐substituted polyketide metabolites from Streptomyces thioluteus and Streptomyces orinoci, respectively, which only differ in the lengths of the polyene backbones. Cloning and sequencing of the 39 kb neoaureothin (nor) biosynthesis gene cluster and its comparison with the aureothin (aur) pathway genes revealed that both polyketide synthase (PKS) assembly lines are remarkably similar. In both cases the module architecture breaks with the principle of colinearity, as individual PKS modules are used in an iterative fashion. Parsimony and neighbour‐joining phylogenetic studies provided insights into the evolutionary process that led to the programming of these unusual type I PKS systems and to prediction of which modules act iteratively. The iterative function of the first module in the neoaureothin pathway, NorA, was confirmed by a successful cross‐complementation.
Effect of Melatonin on Telocytes in the Seminal Vesicle of the Soay Ram: An Immunohistochemical, Ultrastructural and Morphometrical Study

Telocytes (TCs) are a special type of interstitial cell with characteristic cellular processes that are described in many organs. The current study aimed to investigate TCs in seminal vesicles of the Soay ram responding to melatonin treatment during the nonbreeding season by conventional immunohistochemical stains, and to detect the ultrastructural and morphometrical changes of TCs. TCs in the control group showed a broad range of staining affinity and also reacted positively to CD117/c-kit, CD34, desmin, S-100 protein, and progesterone and estrogen receptors alpha, while after melatonin treatment a strong reaction against these 6 antibodies was recorded. Electron microscopically, TCs in the control group were characterized by a small cell body with distinct long cytoplasmic extensions called telopodes (Tps). Tps had alternation of the thin segment (podomers) and dilated segments (podoms), in which the latter accommodate mitochondria, rough endoplasmic reticulum and caveolae. TCs and their Tps were interconnected by homo- and heterocellular junctions and form a wide network to communicate between different cell types. Tps showed close contact with immune cells, progenitor stem cells, smooth muscle cells and other interstitial cells. Melatonin caused a significant increase in the number of TCs, length of Tps, and number and diameter of secretory vesicles. Also, the melatonin-treated group showed exaggerated secretory activity in the form of a massive release of secretory vesicles from Tps. Moreover, Tps showed an increase in their contact with blood and lymphatic capillaries, nerve endings and Schwann cells. In addition, the shedding of secretory structures (exosomes, ectosomes, and multivesicular bodies) was greater from Tps, which were involved in paracrine signaling in the melatonin-treated group. The length and ramifications of Tps together with the intercellular junctions and the releasing of shed vesicles or exosomes assumed an essential role of TCs in intercellular signaling and coordination. On the basis of their distribution and morphology, we investigated whether the different locations of TCs could be associated with different roles.
EpiHosp: A web-based visualization tool enabling the exploratory analysis of complications of implantable medical devices from a nationwide hospital database

Administrative data can be used for the surveillance of the outcomes of implantable medical devices (IMDs). The objective of this work is to build a web-based tool allowing for an exploratory analysis of time-dependent events that may occur after the implementation of an IMD. This tool should enable a pharmacoepidemiologist to explore on the fly the relationship between a given IMD and a potential outcome. This tool mine the French nationwide database of inpatient stays from 2008 to 2013. The data are preprocessed in order to optimize the queries. A web tool is developed in PHP, MySQL and Javascript. The user selects one or a group of IMD from a tree, and can filter the results using years and hospital names. Four result pages describe the selected inpatient stays: (1) temporal and demographic description, (2) a description of the geographical location of the hospital, (3) a description of the geographical place of residence of the patient and (4) a table showing the rehospitalization reasons by decreasing order of frequency. Then, the user can select one readmission reason and display dynamically the probability of readmission by mean of a Kaplan-Meier curve with confidence intervals. This tool enables to dynamically monitor the occurrence of time-dependent complications of IMD.
The Militarization of Civil Society in Guatemala

crat, Venicio Cerezo, the second civilian president since 1954. Because this president was elected in relatively fair and open elections, Guatemala has been touted as one of Latin America’s fledgling democracies. It is clear to everyone familiar with the circumstances preceding and following these elections that the military still holds most of the power in Guatemala and that Cerezo can do little without the explicit approval of the Army High Command. As Nairn and Simon stated: Guatemala’s &dquo;first chief of state in twenty years who would not order the killing of an unarmed civilian . has stated
The social worker as an educator for self-control

Clinical social workers differ from other clinicians by their ability adequately to meet client needs (Wodarski, 1981). Their use of multi-targets and multi-methods is directed toward the achievement of positive change and the solving of human problems (Schinken, 1981). In addition, they aim to embrace shaping, educating and teaching roles, for example to implement self-help skills or problemsolving models. Another distinctive component of clinical social work is the development of new prevention programs for increasing clients’ ability to cope and manage better in the future (Hardiker and Barker, 1981; Wodarski, 1981). The goals of social work have been defined by the National Association of Social Work (NASW) as follows: ’to assist individuals and groups to identify and resolve or minimize problems arising out of disequilibrium between themselves and their environment . to prevent the occurrence of disequilibrium and . to seek out, identify and strengthen the maximum potential in individuals, groups and communities’ (NASW, 1980). These goals can be summarized as: immediate problem-solving; prevention; and facilitating human potential. This paper proposes self-control interventions as a treatment of choice for clinical social workers, in order to address all of these social work goals. It is suggested that, by gradually moving from being therapists who treat immediate problems to becoming teachers of self-help skills and educators for self-control, social workers can facilitate clients to become their own change agents and
Managers' cognitive maps and intra‐organisational performance differences

Purpose – To explore the relationship between managers' cognitive maps and their performance as managers at the same level in the same organisation.Design/methodology/approach – Field study involving 30 branch managers in a financial services organisation operating in New Zealand. A nomthetic approach was used to develop their cognitive maps. Features of these maps were then related to business‐unit performance.Findings – The managers who were higher performing have maps that were considerably simpler, using fewer concepts and fewer linkages.Research limitations/implications/future research – While limited to one organisation and to one level of management, there is evidence that cognition is related to managers' performance. Future research should explore how cognitive structures differ between managerial levels, and how these are related to appropriate measures of performance.Originality/value – One of few studies that have sought to map managers' cognition and organisation performance.
Defects in the Peripheral Taste Structure and Function in the MRL/lpr Mouse Model of Autoimmune Disease

While our understanding of the molecular and cellular aspects of taste reception and signaling continues to improve, the aberrations in these processes that lead to taste dysfunction remain largely unexplored. Abnormalities in taste can develop in a variety of diseases, including infections and autoimmune disorders. In this study, we used a mouse model of autoimmune disease to investigate the underlying mechanisms of taste disorders. MRL/MpJ-Faslpr/J (MRL/lpr) mice develop a systemic autoimmunity with phenotypic similarities to human systemic lupus erythematosus and Sjögren's syndrome. Our results show that the taste tissues of MRL/lpr mice exhibit characteristics of inflammation, including infiltration of T lymphocytes and elevated levels of some inflammatory cytokines. Histological studies reveal that the taste buds of MRL/lpr mice are smaller than those of wild-type congenic control (MRL/+/+) mice. 5-Bromo-2′-deoxyuridine (BrdU) pulse-chase experiments show that fewer BrdU-labeled cells enter the taste buds of MRL/lpr mice, suggesting an inhibition of taste cell renewal. Real-time RT-PCR analyses show that mRNA levels of several type II taste cell markers are lower in MRL/lpr mice. Immunohistochemical analyses confirm a significant reduction in the number of gustducin-positive taste receptor cells in the taste buds of MRL/lpr mice. Furthermore, MRL/lpr mice exhibit reduced gustatory nerve responses to the bitter compound quinine and the sweet compound saccharin and reduced behavioral responses to bitter, sweet, and umami taste substances compared with controls. In contrast, their responses to salty and sour compounds are comparable to those of control mice in both nerve recording and behavioral experiments. Together, our results suggest that type II taste receptor cells, which are essential for bitter, sweet, and umami taste reception and signaling, are selectively affected in MRL/lpr mice, a model for autoimmune disease with chronic inflammation.
The N ii spectrum of the Orion nebula

The predicted emission spectrum of N II is compared with observations of permitted lines in the Orion nebula. Conventional nebular models show that the intensities of the more intense lines can be explained by fluorescence of starlight absorption wit haNa bundance that is consistent with forbidden lines. Lines excited mostly by recombination, on the other hand, predict high Na b undances. The effects of stellar and nebular parameters and of the atomic data on the predicted intensities are examined. Ke yw ords: line: formation ‐ ISM: individual: Orion nebula.
What is in a recommendation? A perspective from work-based doctorates

This paper is about writing effective recommendations for action based on inquiries, evidence or arguments that have the purpose of effecting change. The importance of the topic for higher education is evident in the increasing accountability being asked of research from within institutions, in other words, research which provides evidenced-based conclusions but which need compelling recommendations for them to be acted upon. These recommendations might be for individuals or organisations and can range from the personal to the collective through a range of approaches and settings or workplaces: home, school, factory or business hub. Recommendations are calls to action that need to be persuasive if they are to convince others to act. We discuss how recommendations might be developed and presented calling firstly on the insights found in Aristotle’s Rhetoric and then developing a phronetic method for presenting recommendations with the intent of helping them achieve the legitimate goals of their authors, supported by a review of 20 work-based doctorates.
Securing FPGA SoC configurations independent of their manufacturers

System-on-Chips which include FPGAs are important platforms for critical applications since they provide significant software performance through multi-core CPUs as well as high versatility through integrated FPGAs. Those integrated FP-GAs allow to update the programmable hardware functionality, e.g. to include new communication interfaces or to update cryptographic accelerators during the life-time of devices. Updating software as well as hardware configuration is required for critical applications such as e.g. industrial control devices or vehicles with long life-times. Such updates must be authenticated and possibly encrypted. One way to achieve this is to rely on static FPGA manufacturer-provided cryptography and respective master keys. However, in this contribution, we show how to retrofit Xilinx Zynq FPGAs with an alternative cryptographic accelerator and how to establish device-individual keys using Physical Unclonable Function (PUF) technology. These two key aspects reduce the required trust in manufacturer-provided security features while increasing the security by binding configurations to a specific device.
Mapping of rescue environments with Kurt3D

Deploying rescue workers in an urban setting is often a perilous, time-, power-, and force-consuming job, and systems to assist in this effort are needed. A fundamental task for rescue is to localize injured persons. To this end, robotic systems are used for mapping a site and for remote inspection of suspicious objects. The mobile robot Kurt3D is the first rescue robot that is capable of mapping its environment in 3D and self localize in all six degrees of freedom, i.e., considering its x, y and z positions and the roll, yaw and pitch angles.
Guanine nucleotide dissociation inhibitor is essential for Rab1 function in budding from the endoplasmic reticulum and transport through the Golgi stack

The small GTPase Rab1 is required for vesicular traffic from the ER to the cis-Golgi compartment, and for transport between the cis and medial compartments of the Golgi stack. In the present study, we examine the role of guanine nucleotide dissociation inhibitor (GDI) in regulating the function of Rab1 in the transport of vesicular stomatitis virus glycoprotein (VSV-G) in vitro. Incubation in the presence of excess GDI rapidly (t1/2 < 30 s) extracted Rab1 from membranes, inhibiting vesicle budding from the ER and sequential transport between the cis-, medial-, and trans-Golgi cisternae. These results demonstrate a direct role for GDI in the recycling of Rab proteins. Analysis of rat liver cytosol by gel filtration revealed that a major pool of Rab1 fractionates with a molecular mass of approximately 80 kD in the form of a GDI-Rab1 complex. When the GDI-Rab1 complex was depleted from cytosol by use of a Rab1-specific antibody, VSV-G failed to exit the ER. However, supplementation of depleted cytosol with a GDI-Rab1 complex prepared in vitro from recombinant forms of Rab1 and GDI efficiently restored export from the ER, and transport through the Golgi stack. These results provide evidence that a cytosolic GDI-Rab1 complex is required for the formation of non-clathrin-coated vesicles mediating transport through the secretory pathway.
‘Continue or terminate?’ Determinants of long-term volunteering in sports clubs

Abstract This study analyzed the determinants underlying sports club volunteers' tendencies to continue or terminate their long-term commitment to volunteering in order to help sports clubs improve their volunteer management. Their risk of terminating was viewed in terms of subjective expectations and evaluations (satisfaction) regarding club-related working conditions and normative commitments (solidarity) to the sports club. These relationships were tested empirically with an online questionnaire of 441 sports club volunteers in a selection of 45 Swiss sports clubs. Results showed that the constructs orientation toward collective solidarity and volunteer job satisfaction correlated positively with long-term volunteering commitment. The effect of the former was stronger than that of the latter. Volunteers with a higher orientation toward collective solidarity were unlikely to terminate their voluntary engagement in their club. The discussion presents recommendations to help clubs retain volunteers.
Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori.

BACKGROUND & AIMS LL-37/human cationic antimicrobial peptide 18 (hCAP18) is a human cathelicidin with broad-spectrum antimicrobial, lipopolysaccharide binding, and chemotactic activities. This study examined the role of LL-37/hCAP18 in gastric innate immune defense by characterizing its constitutive and regulated expression by human gastric mucosa and its bactericidal activity against the gastric pathogen Helicobacter pylori. METHODS LL-37/hCAP18 messenger RNA expression in normal and H. pylori -infected gastric mucosa and gastric epithelial cells was determined by in situ hybridization, real-time polymerase chain reaction, immunostaining, and immunoblot analysis. Bactericidal activity was measured by using a colony-forming unit assay. RESULTS LL-37/hCAP18 messenger RNA and protein were expressed in a distinct distribution by surface epithelial cells as well as chief and parietal cells in the fundic glands of normal gastric mucosa. LL-37/hCAP18 was significantly increased in the epithelium and gastric secretions of H. pylori -infected patients, but not in individuals with non-H. pylori -induced gastric inflammation. Infection of cultured gastric epithelial cells with a wild-type but not an isogenic Delta cagE mutant strain of H. pylori increased LL-37/hCAP18 expression, indicating that H. pylori -induced regulation of LL-37/hCAP18 production required an intact type IV secretion system. LL-37, the C-terminal peptide of LL-37/hCAP18, alone or in synergy with human beta-defensin 1, was bactericidal for several H. pylori strains. CONCLUSIONS These data indicate that H. pylori up-regulates production of LL-37/hCAP18 by gastric epithelium and suggest this cathelicidin contributes to determining the balance between host mucosal defense and H. pylori survival mechanisms that govern chronic infection with this gastric pathogen.
Characteristics of Cannabis-Only and Other Drug Users Who Visit the Emergency Department

Abstract Emergency department (ED) settings have gained interest as venues for illegal drug misuse prevention and intervention, with researchers and practitioners attempting to capitalize on the intersection of need and opportunity within these settings. This study of 686 adult patients visiting two EDs for various reasons who admitted drug use compared daily cannabis-only users, nondaily cannabis-only users, and other drug users on sociodemographic and drug-related severity outcomes. The three drug use groups did not differ on most sociodemographic factors or medical problem severity scores. Forty-five percent of the sample was identified as having a drug use problem. ED patients who used drugs other than cannabis were at particular risk for high drug use severity indicators and concomitant problems such as psychiatric problems and alcohol use severity. However, 19–29% of cannabis-only users were identified as having problematic drug use. Furthermore, daily cannabis-only users fared less well than nondaily cannabis users with regard to drug use severity indicators and self-efficacy for avoiding drug use. Results may assist emergency medicine providers and medical social workers in matching patients to appropriate intervention. For example, users of drugs other than cannabis (and perhaps heavy, daily cannabis-only users) may need referral to specialty services for further assessment. Enhancement of motivation and self-efficacy beliefs could be an important target of prevention and treatment for cannabis-only users screened in the ED.
Multiple levels of schematization: A study in the conceptualization of space

Previous network accounts of polysemy (Brugman 1981, Lakoff 1987, Dewell 1994) have used image Schemata to motivate and define the various senses of a single lexical item; while the application of image-schematic structure to lexical semantics is taken äs ultimately beneficial, such analyses have not been systematically constrained. The present study, inspired by Talmy (1983), distinguishes between three levels of image-schematic structure: (1) the component level, (2) the relational level, and (3) the integrative level; by restricting prepositional senses to the relational level and image Schema transformations to the component level a principally constrained, yet widely applicable model of polysemy structure is demonstrated. V sing the well-studied preposition over äs an example, the composition and application of relational and integrative level Schemata is examined.
Apoptosis by Neglect of CD4+ Th Cells in Granulomas: A Novel Effector Mechanism Involved in the Control of Egg-Induced Immunopathology in Murine Schistosomiasis1

In infection with Schistosoma mansoni, parasite eggs precipitate an intrahepatic granulomatous and fibrosing inflammation that is mediated by CD4+ Th cells. Compared with CBA mice, C57BL/6 mice develop smaller granulomas composed of cells that exhibit reduced proliferative responses to schistosome egg Ags. In the present study, we investigated CD4+ T cell apoptosis as a possible mechanism that could account for this subdued response. We found throughout the course of several infection weeks a markedly higher proportion of apoptotic CD4+ T cells in granulomas from C57BL/6 mice than in those from CBA mice ex vivo; the apoptosis further increased upon cell cultivation in vitro. Activation-induced cell death or CD8+ T cells failed to account for the enhanced apoptosis as infected Fas-, Fas ligand,- and CD8-deficient mice exhibited similar apoptosis to that seen in wild-type counterparts. However, a strikingly lower IL-2 production by schistosome egg Ag-stimulated C57BL/6 granuloma and mesenteric lymph node cells suggested the possibility of apoptosis due to growth factor deprivation. Indeed, the CD4+ T cell apoptosis was significantly reversed by addition of rIL-2 in vitro, or by injection of rIL-2 in vivo, which also resulted in significant exacerbation of granulomatous inflammation. These findings indicate that apoptosis by neglect can represent a significant means of controlling CD4+ T cells that mediate the immunopathology in schistosomiasis.