Miracle-dz/UniFAR-FTUs huggingface dataset:
Proliferative and apoptotic differences between alveolar rhabdomyosarcoma subtypes: a comparative study of tumors containing PAX3-FKHR or PAX7-FKHR gene fusions.

BACKGROUND Most alveolar rhabdomyosarcomas (ARMS) have chromosome translocations and resultant gene fusion products. The more common translocation fuses the PAX3 and FKHR genes; patients who have PAX3-FKHR-positive ARMS have reduced event-free survival compared to patients with ARMS containing the less common translocation that fuses the PAX7 and FKHR genes. PROCEDURE We examined histology, immunohistochemical markers of differentiation, and cell cycle characteristics of a panel of ARMS containing either PAX3-FKHR or PAX7-FKHR transcript to determine if these features differ between the ARMS subsets. RESULTS Cell cycle parameters varied significantly: the number of nuclei that stained with either an immunohistochemical marker of proliferation (MIB1), or a TUNEL-based assay for apoptosis was significantly greater in tumors that expressed PAX3-FKHR compared to tumors that expressed PAX7-FKHR transcript. CONCLUSIONS We conclude that compared to PAX7-FKHR-containing tumors, ARMS that contain PAX3-FKHR transcript have (1) increased cell proliferation, consistent with greater loss of cell cycle regulation, and (2) apoptosis that is increased but insufficient to prevent tumor formation. More marked cell cycle dysregulation may contribute to poorer prognosis for patients with ARMS that have PAX3-FKHR fusion. Med Pediatr Oncol 2001;37:83-89.
Teachers' survey on problems with handwriting: referral, evaluation, and outcomes.

OBJECTIVE The purpose of this study was to describe the factors that led elementary school teachers to refer students with handwriting difficulties to occupational therapy, the criteria they used to determine acceptable handwriting, and the handwriting outcomes they looked for after occupational therapy services. METHOD A paper questionnaire composed of 31 close-ended questions was mailed to 400 first- through fourth-grade regular education teachers from 32 states to collect data from the 2000-2001 school year. The data were analyzed descriptively using frequency counts and converted to percentages. RESULTS Information was obtained from 314 teachers. The main factor for handwriting referral to occupational therapy was that the student was not improving with classroom assistance alone. Teachers chose not being able to read student's writing as the main criterion they used to determine if the student's handwriting was acceptable, and increased legibility was the most important outcome they desired following occupational therapy services for handwriting remediation. CONCLUSION The perceptions of regular education teachers on problems with handwriting can provide valuable information to occupational therapy practitioners when providing consultation and direct services related to handwriting in schools.
Enhanced Vocal Performance Tracking Using Multiple Information Sources

We describe an enhanced statistical method for tracking vocal performances in real time. This approach integrates multiple measurements of the sound signal that are relevant to determining score position. The information is combined using a statistical model that incorporates distributions estimated from actual vocal performances. We present results from using different combinations of signal measurements to track both recorded and live performances. Results of this testing indicate some requirements for successfully using multiple information sources to improve automated vocal performance tracking.
Fluorescent serum and urinary advanced glycoxidation end-products in non- diabetic subjects.

INTRODUCTION Advanced glycoxidation end-products (AGEs) are involved in age-related conditions and diabetic complications. Diet intake contributes to their circulating concentrations. AIM To measure serum and urinary AGEs in non-diabetic volunteers and relate their concentration to body composition, blood chemistry and dietary ingestion. METHODS We studied 41 adult men (31 middle-aged adults and 10 elderly). A nutritional assessment including a dietary recall designed for detection of AGE ingestion (specifically carboxymethyl-lysine(CML)), and anthropometric measurements were performed. Also serum lipoproteins, insulin, glucose, leptin and C reactive protein (CRP). AGEs were measured in serum and urine samples using size exclusion chromatography and flow injection assay (FIA); the technical procedures were first employed in 11 heterogeneous diabetics, as positive controls for this methodology. RESULTS Serum and urinary chromatograms indicated that areas under the curve were not different in younger compared with elderly adults. AGEs did not correlate with dietary intake, body composition, nor metabolic parameters, however they correlated significantly with renal function and CRP concentration. DISCUSSION In these non-diabetic volunteers, with low CML intake, serum and urinary concentration of AGEs were not related to dietary intake. AGEs were related to renal function and CRP, but not to body composition, lipoproteins, insulin and glucose.
Ordered Subspace Clustering With Block-Diagonal Priors

Many application scenarios involve sequential data, but most existing clustering methods do not well utilize the order information embedded in sequential data. In this paper, we study the subspace clustering problem for sequential data and propose a new clustering method, namely ordered sparse clustering with block-diagonal prior (BD-OSC). Instead of using the sparse normalizer in existing sparse subspace clustering methods, a quadratic normalizer for the data sparse representation is adopted to model the correlation among the data sparse coefficients. Additionally, a block-diagonal prior for the spectral clustering affinity matrix is integrated with the model to improve clustering accuracy. To solve the proposed BD-OSC model, which is a complex optimization problem with quadratic normalizer and block-diagonal prior constraint, an efficient algorithm is proposed. We test the proposed clustering method on several types of databases, such as synthetic subspace data set, human face database, video scene clips, motion tracks, and dynamic 3-D face expression sequences. The experiments show that the proposed method outperforms state-of-the-art subspace clustering methods.
Mindsets for Green Innovation

Managers’ mindset about the sustainability construct and its triggers is the topic dealt with in the paper. The interviewed managers are all working in companies expressing a commitment on sustainability in their external communication. However, our findings reveal that their commitment is pursued from different business models, visions and ideas about the sustainability construct. We found that sustainability is not triggered, approached and practiced in accordance with one overall mindset. Four interrelated mindsets emerged due to that sustainability is a learning process and thus formed and developed over time.
Factors of Competitiveness for the Bovine Livestock in Yucatan, Mexico

This chapter’s objective is to show that finance, marketing and innovation could be considered as factors of competitiveness. Owners of 30 cattle ranches were included in the state surveys, with each ranch having at least 1000 head of cattle. The study was quantitative and used a multiple linear regression model. The results were that the use of financial information, the profitability and funding are components of finance factor. The product and the process innovation are components of innovation factor and the market positioning, the knowledge of the competition and customer satisfaction are components of marketing factor, being the profitability, the market positioning, the customer satisfac tion, the product and the process innovation, relatively more important.
Determinants influencing Pakistani Consumers to purchase Counterfeit products

The present study analysed the determinants which encourage Pakistani consumers to willingly purchase counterfeit products. Total five variables were selected and out of five three were independent variables i.e. economic benefits, materialism, and perceived value. The purchase intention was used as mediating variable and consumer behaviour was taken as a dependent variable. A theoretical model was developed by combining these variables and empirically tested as shown in figure 1. The theory of planned behaviour provided bases for theoretical support to the proposed model which resulted in the development of seven hypotheses. The results confirmed that all independent variables positively related to purchase intention and consumer behaviour. Furthermore, purchase intention also had a mediating effect on independent variables. The model was found satisfactory from the goodness-of-fit point of view and all values are in the range of accepted fit and based on these results, all proposed hypotheses were accepted positively.
Autosomal dominant polycystic kidney disease

#### What you need to know Polycystic kidney disease (PKD) is an inherited condition defined by the pathological development of fluid-filled cysts throughout the kidneys leading to organ enlargement (fig 1⇓) and chronic kidney disease. Autosomal dominant polycystic kidney disease (ADPKD) is the commonest inherited kidney disease1 and is the fourth commonest cause of kidney failure worldwide.2 Autosomal recessive PKD is a rare disease usually identified antenatally or during the neonatal period by enlarged echogenic kidneys on ultrasound.3 This review will focus on ADPKD. Fig 1 Anatomical illustration of a polycystic kidney (right) compared with a normal kidney (left) #### Sources and selection criteria I searched PubMed, Clinical Evidence, and the Cochrane Library for primary and review articles available in English until October 2015. Articles included systematic reviews, randomised clinical trials, and observational studies. The following search terms were used in isolation and combination: “ADPKD,” “polycystic kidney disease,” “progression,” “treatment,” “humans,” “complications,” “mutations. ” I identified additional references from my personal archive. Where evidence based medicine was not available, published expert opinion was referenced. ADPKD presents to a variety of doctors and is more prevalent than the combination …
Dynamic efficiency: intellectual capital in the Chinese non-life insurance firms

Purpose – This paper aims to investigate the effect of intellectual capital (IC) on the operating efficiency of non-life insurance firms in China. Design/methodology/approach – The authors use a dynamic data envelopment analysis model called dynamic slacks-based measure (DSBM) model to estimate the operating efficiency of 32 Chinese non-life insurance firms. Using a panel data set for the period from 2006 to 2010, the authors run ordinary least squares (OLS) regressions to find the relationship between IC and efficiency performance. Findings – The authors find that the insurers have almost monotonically decreasing efficiency for the period from 2006 to 2010. Regression results show that human capital, structural capital and relational capital are significantly and positively related to operating efficiency. Research limitations/implications – This study suggests that managers of the Chinese non-life insurers should devote attention to the investments in IC to stay sustainable. Originality/value – This is .
Notice of RetractionComputational Modeling of the Antithrombotic Antibody SZ2 in Complex with Glycoprotein Ibalpha

Binding of platelet glycoprotein Ibα (GPIbα) to von Willebrand factor (vWF) is closely related to the process of physiological hemostasis and pathological thrombosis. Monoclonal antithrombotic antibody SZ2 can inhibit ristocetin induced platelet agglutination and thrombin-induced platelet aggregation via binding to the anionic region of GPIbα. To investigate the interaction between SZ2 and GPIbα at the residue level, here we perform a computational modeling via homology modeling, molecular docking and intermolecular interactions analysis. Proper conformations of SZ2 and SZ2/GPIbα complex are presented; the key residues in SZ2 and GPIbα are also identified, which are consistent with known experimental evidence. Our study may provide novel insights into SZ2 modification and antibody research, especially in lacking of both crystal structures and mutagenesis data.
Regulation of Human FcεRI α-Chain Gene Expression by Multiple Transcription Factors

Transcriptional regulation of the gene-encoding human FcεRI α-chain was analyzed in detail. EMSA revealed that either YY1 or PU.1 bound to the region close to that recognized by Elf-1. The α-chain promoter activity was up-regulated ∼2-fold by exogenously expressed YY1 or PU.1 and ∼7-fold by GATA-1, respectively, in KU812 cells. In contrast, coexpression of GATA-1 with either of PU.1 or YY1 dramatically activated the promoter ∼41- or ∼27-fold, respectively. Especially synergic activation by GATA-1 and PU.1 was surprising, because these transcription factors are known to inhibit the respective transactivating activities of each other. These up-regulating effects of PU.1 and YY1 with GATA-1 were inhibited by overexpression of Elf-1, indicating that Elf-1 serves as a repressor for the α-chain gene expression. Transcriptional regulation of the α-chain gene through four transcriptional factors is discussed.
Controlled hypercapnia during one‐lung ventilation in patients undergoing pulmonary resection

Background: In a pilot study, the haemodynamic and gas exchange effects of acute hypercapoia during one‐lung ventilation in thoracotomy patients were investigated. The effects of normocapnic one‐lung ventilation (OLV‐N) on haemodynamics and pulmonary gas exchange were compared with those of hypercapnic one‐lung ventilation (OLV‐H) in 14 patients undergoing pulmonary lobectomy.
Innovator-Firm Collaboration: The Moderating Role of Transactional Capacity (TC)

Product innovation’s success at research and development level, does not guarantee that it will lead to the success in commercialization stage. Despite the enormous research efforts, the commercialization rates of product innovation are still at an alarming level in many countries including Malaysia. While collaboration has been acknowledged as pertinent to the success of innovation product commercialization, the collaborative effort between innovation recipient firm and the innovators remains limited. Besides, one of the central questions is how and under what condition the two parties are more likely to engage in a resilient collaborative effort, from the perspective of innovation recipient firms remain unclear. This new perspective requires an understanding of the relationship between collaboration and commercialization performance and the moderating effect of TC from firm’s perspective. Based on the response of 104 product innovation recipient firms, the findings show that collaboration positively affects firm’s market performance and innovation survival. In addition, transactional capacity gives medium effect to collaboration, leading to better firm’s innovation survival. This study contributes to the literature by exploring how close collaboration between firm and innovator initiates to enhance the firm’s market performance and innovation survival. It also increases our understanding of how TC relate to collaboration and market performance and innovation survival.
Epizootic Mortality of Free-living Green Turtles, Chelonia mydas, Due to Coccidiosis

At least 70 wild green sea turtles, Chelonia mydas, died in the Moreton Bay area of southeast Queensland, Australia over 6 wk in spring 1991. Based on the necropsy of 24 turtles, there was a severe enteritis or encephalitis associated with Caryospora cheloniae, a coccidial pathogen previously recorded only in farm reared Ch. mydas hatchlings. Infection was characterized by the presence of coccidia in extra-intestinal lesions. Oocysts were observed to sporulate, after which sporozoites escaped into seawater to form a novel stellate configuration. We conclude that C. cheloniae is pathogenic for life stages other than hatchling Ch. mydas and that naturally-occurring coccidiosis is a significant disease of free-living Ch. mydas.
Cytokeratin 20 Confirms Merkel Cell Metastasis to Stomach

Merkel cell carcinoma (MCC) is an uncommon, aggressive neuroendocrine carcinoma of the skin. Its prognosis is poor because of involvement of regional lymph nodes and metastases to distant sites such as bone, liver, lung, and brain. Very few metastases are reported to the gastrointestinal tract. Several studies have shown the utility of cytokeratin 20 to differentiate MCC from other small round blue cell tumors, particularly those with neuroendocrine differentiation. In this case report, we present an unusual metastasis to the stomach and the utility of cytokeratin 20 immunohistochemistry to confirm MCC.
INTESTINAL ABSORPTIVE CAPACITY AND SITE OF ABSORPTION OF FAT UNDER STEADY STATE CONDITIONS IN THE UNANAESTHETIZED RAT.

The maximum intestinal absorptive capacity for tricaprylin (C8) was established, and found to be approximately four times that for coconut oil (70 per cent C12 fatty acids). Infusion of fats of varying chain length into gut remaining after resection of most of the jejunum or most of the ileum revealed little difference in proximal and distal absorptions. In addition, the maximum absorptive capacity for tricaprylin was not significantly reduced by removal of 40 per cent of the small intestine, either jejunum or ileum. The results suggest that rapid propulsion through the proximal intestine prevents proximal absorption under normal conditions, but that true regional specificity for fat absorption does not exist in rats.
Exploiting Bishun to Predict the Pronunciation of Chinese

Learning to pronounce Chinese characters is usually considered as a very hard part to foreigners to study Chinese. At beginning, Chinese learners must bear in mind thousands of Chinese characters, including their pronunciation, meanings, Bishun (order of strokes) etc., which is very time consuming and boring. In this paper, we proposed a novel method based on translation model to predict the Chinese character pronunciation automatically. We first convert each Chinese character into Bishun, then, we train the pronunciation prediction model (translation model) according to Bishun and their correspondence Pinyin sequences. To make our model practically, we also introduced some error tolerant strategies. Experimental results show that our method can predict the pronunciation of Chinese characters effectively.
How Customer Affect Agile Transition and Adoption Process

— Software teams and companies are continually leaving plan driven methods and replacing them by Agile methods in software development. One of the most important reasons for this process is gaining more quality in software products. This process as a multi-dimensional process encompasses several factors, enablers, challenges, and obstacles. Conducting a large scale qualitative research study revealed various hidden aspects of the above process. This paper presents the role of customers as one of the most critical roles in Agile transition and adoption. This study showed that customers significantly influence the change process and can be considered as both successful and failure factors in the transformation.
MODIS Retrieval of Aerosol Optical Depth over Turbid Coastal Water

We present a new approach to retrieve Aerosol Optical Depth (AOD) using the Moderate Resolution Imaging Spectroradiometer (MODIS) over the turbid coastal water. This approach supplements the operational Dark Target (DT) aerosol retrieval algorithm that currently does not conduct AOD retrieval in shallow waters that have visible sediments or sea-floor (i.e., Class 2 waters). Over the global coastal water regions in cloud-free conditions, coastal screening leads to ~20% unavailability of AOD retrievals. Here, we refine the MODIS DT algorithm by considering that water-leaving radiance at 2.1 µm to be negligible regardless of water turbidity, and therefore the 2.1 µm reflectance at the top of the atmosphere is sensitive to both change of fine-mode and coarse-mode AODs. By assuming that the aerosol single scattering properties over coastal turbid water are similar to those over the adjacent open-ocean pixels, the new algorithm can derive AOD over these shallow waters. The test algorithm yields ~18% more MODIS-AERONET collocated pairs for six AERONET stations in the coastal water regions. Furthermore, comparison of the new retrieval with these AERONET observations show that the new AOD retrievals have equivalent or better accuracy than those retrieved by the MODIS operational algorithm’s over coastal land and non-turbid coastal water product. Combining the new retrievals with the existing MODIS operational retrievals yields an overall improvement of AOD over those coastal water regions. Most importantly, this refinement extends the spatial and temporal coverage of MODIS AOD retrievals over the coastal regions where 60% of human population resides. This expanded coverage is crucial for better understanding of impact of aerosol particles on coastal air quality and climate.
Crystal Structure of Dengue Virus Type 1 Envelope Protein in the Postfusion Conformation and Its Implications for Membrane Fusion

ABSTRACT Dengue virus relies on a conformational change in its envelope protein, E, to fuse the viral lipid membrane with the endosomal membrane and thereby deliver the viral genome into the cytosol. We have determined the crystal structure of a soluble fragment E (sE) of dengue virus type 1 (DEN-1). The protein is in the postfusion conformation even though it was not exposed to a lipid membrane or detergent. At the domain I-domain III interface, 4 polar residues form a tight cluster that is absent in other flaviviral postfusion structures. Two of these residues, His-282 and His-317, are conserved in flaviviruses and are part of the “pH sensor” that triggers the fusogenic conformational change in E, at the reduced pH of the endosome. In the fusion loop, Phe-108 adopts a distinct conformation, forming additional trimer contacts and filling the bowl-shaped concavity observed at the tip of the DEN-2 sE trimer.
The Impact of IFRS Adoption on Earnings Management in Russia

The purpose of this study is to examine the effect of International Financial Reporting Standards (IFRS) adoption on the frequency of earnings management in Russia according to accruals-based approach.The empirical analysis employs the linear regression model which includes a dependent variable (discretionary accruals), an independent variable (accounting standards) and some control variables. The sample used for the analysis contains 361 observations of Russian public companies from various industries during the period from 2010 to 2015. It is anticipated to obtain the result showing that earnings management is intensified after IFRS implementation.