Miracle-dz/UniFAR-FTUs huggingface dataset:
Epiprofin orchestrates epidermal keratinocyte proliferation and differentiation

ABSTRACT The basal layer of the epidermis contains stem cells and transit amplifying cells that rapidly proliferate and differentiate further into the upper layers of the epidermis. A number of molecules have been identified as regulators of this process, including p63 (also known as tumor protein 63) and Notch1. However, little is known about the mechanisms that regulate the transitions from stem cell to proliferating or differentiating transit amplifying cell. Here, we demonstrate that epiprofin (Epfn, also known as Sp6) plays crucial distinct roles in these transition stages as a cell cycle regulator and a transcription factor. Epfn knockout mice have a thickened epidermis, in which p63-expressing basal cells form multiple layers owing to the accumulation of premature transit amplifying cells with reduced proliferation and a reduction in the number of differentiating keratinocytes expressing Notch1. We found that low levels of Epfn expression increased the proliferation of human immortalized keratinocyte (HaCaT) cells by increasing EGF responsiveness and superphosphorylation of Rb. By contrast, high levels of Epfn expression promoted cell cycle exit and differentiation, by reducing E2F transactivation and inducing Notch1 expression. Our findings identify multiple novel functions of Epfn in epidermal development.
Cochlear implant optimized noise reduction

Noise-reduction methods have provided significant improvements in speech perception for cochlear implant recipients, where only quality improvements have been found in hearing aid recipients. Recent psychoacoustic studies have suggested changes to noise-reduction techniques specifically for cochlear implants, due to differences between hearing aid recipient and cochlear implant recipient hearing. An optimized noise-reduction method was developed with significantly increased temporal smoothing of the signal-to-noise ratio estimate and a more aggressive gain function compared to current noise-reduction methods. This optimized noise-reduction algorithm was tested with 12 cochlear implant recipients over four test sessions. Speech perception was assessed through speech in noise tests with three noise types; speech-weighted noise, 20-talker babble and 4-talker babble. A significant speech perception improvement using optimized noise reduction over standard processing was found in babble noise and speech-weighted noise and over a current noise-reduction method in speech-weighted noise. Speech perception in quiet was not degraded. Listening quality testing for noise annoyance and overall preference found significant improvements over the standard processing and over a current noise-reduction method in speech-weighted and babble noise types. This optimized method has shown significant speech perception and quality improvements compared to the standard processing and a current noise-reduction method.
A CVAR Scenario for a Standard Monetary Model Using Theory-Consistent Expectations

A theory-consistent CVAR scenario describes a set of testable regularities capturing basic assumptions of the theoretical model. Using this concept, the paper considers a standard model for exchange rate determination and shows that all assumptions about the model? s shock structure and steady-state behavior can be formulated as testable hypotheses on common stochastic trends and cointegration. While the scenario was rejected on essentially all counts, the results were informative about the cause of the empirical failure. It was the stationarity assumptions that were too restrictive to explain the long persistent swings in the real exchange rate and the interest rate differential.
The preliminary results of a comparative effectiveness evaluation of adhesiolysis and caudal epidural injections in managing chronic low back pain secondary to spinal stenosis: a randomized, equivalence controlled trial.

BACKGROUND Lumbar surgery and epidural injections for spinal stenosis are the most commonly performed interventions in the United States. However, there is only moderate evidence to the effectiveness of surgery and caudal epidural injections. The next sequential step is adhesiolysis and hypertonic neurolysis with targeted delivery. There have not been any randomized trials evaluating the effectiveness of percutaneous adhesiolysis and targeted delivery of local anesthetic, steroid and hypertonic sodium chloride solution in lumbar spinal stenosis. STUDY DESIGN A randomized, equivalence, controlled trial. SETTING An interventional pain management practice, a specialty referral center, a private practice setting in the United States. OBJECTIVES To evaluate the effectiveness of percutaneous epidural adhesiolysis in patients with chronic low back and lower extremity pain with lumbar central spinal stenosis and compare with fluoroscopically directed caudal epidural injections. METHODS Patients were randomly assigned to one of 2 groups with 25 patients in each group. Group I patients received caudal epidural injections with catheterization up to S3 with local anesthetic, 0.9% sodium chloride solution, non-particulate betamethasone and served as the control group. Group II patients received percutaneous adhesiolysis with targeted delivery and injection of lidocaine, 10% hypertonic sodium chloride solution, and non-particulate Betamethasone and formed the intervention group. Randomization was performed by computer-generated random allocation sequence by simple randomization. OUTCOMES ASSESSMENT Multiple outcome measures were utilized including the Numeric Rating Scale (NRS), the Oswestry Disability Index 2.0 (ODI), employment status, and opioid intake with assessment at 3, 6, and 12 months post treatment. Significant pain relief was described as 50% or more, whereas significant improvement in the disability score was defined as a reduction of 40% or more. RESULTS This evaluation showed significant pain relief (>or= 50%) in 76% of the patients at one year follow-up in the adhesiolysis group compared to 4% of the patients in the control group. LIMITATIONS The results of this study are limited by the lack of a placebo group, the fact that it is a preliminary report, and there are only 25 patients in each group. CONCLUSIONS With significant pain relief in 76% of patients, percutaneous adhesiolysis utilizing local anesthetic, steroids and hypertonic sodium chloride solution may be effective in patients with chronic function-limiting low back and lower extremity pain with spinal stenosis.
Quality management, strategic priorities and performance: the quality leadership

– The purpose of this paper is to clarify whether there are differences in the implementation of quality management (QM) and the results achieved, based on the position of the person responsible for QM and his/her strategic priorities. , – Data from 256 firms that have implemented QM are collected. A multigroup analysis with LISREL is employed to contrast the hypotheses using a sample of general managers on the one hand and of quality managers on the other. , – This study shows that QM is stronger implemented when it is headed by the general manager than by the quality manager. The authors also find that in both samples of general managers and quality managers, only one of the three strategic priorities analyzed, cost orientation, shows a positive effect on financial results. When the influence of QM on financial results is considered, the relationship is significant just in the case of the sample of quality directors. , – The limitations of the analysis performed suggest lines of research that can substantially enrich the analysis of the role of management in the implementation of QM systems. A first step would be to expand the study sample, since the subsample for general managers was not very large. Gathering more recent data could contribute to strengthening the results obtained and to identifying additional explanatory variables. For example, information on functional experience or training could clarify the strategic focus adopted by managers. , – This study highlights that the general manager's commitment to quality confers greater credibility in the rest of the organization. Although the general managers impose greater implementation of QM, they do not perceive that this influences the financial results achieved directly. The incorporation of strategic priorities in this study also shows that the perception of differentiation in marketing in firms that have implemented QM is similar both for quality managers and for general managers. However, the former (quality managers) also show that differentiation in innovation has a positive effect on QM. , – Literature has shown an indisputable consensus on the relevance of leadership and the commitment of top management to the success of QM, but few studies provide more in‐depth specific knowledge of the characteristics and actions developed by the person who leads the commitment to quality. This study tackles the role of the manager responsible for QM in the firm, based on his or her functional position, whether general manager or quality manager. It contributes by investigating how a manager's strategic priorities condition the level of QM implementation, as well as the financial performance achieved.
Combating homegrown extremism: assessing common critiques and new approaches for CVE in North America

ABSTRACT Counter Violent Extremism (CVE) programs have become an increasingly important piece of counterterrorism strategies in North America since 2001 in order to combat homegrown extremism. Recent events have brought this issue into the fore once again. However, these programs are relatively new and under-evaluated, with many commentators noting their inadequacies. The purpose of this research note is to explore some of the common critiques of CVE programs, and to consider new approaches which might make CVE efforts more effective in the years to come. This note also sets the base for new areas of CVE research moving forward.
Analysis of Influence of Sponsorship Career Function of Mentorship on Women’s Leadership Advancement in Kenyan Universities

Women working in Kenyan universities should be provided with the many benefits of sponsorship, a mentorship function. Mentors should for example give their mentees challenging assignments which prepare them for top leadership positions. But it is possible that women may not be getting this support from their mentors. Therefore, the researcher did this study for the purpose of establishing the influence of sponsorship on women’s leadership advancement in Kenyan universities. A mixed methodology, using a triangulation design-convergence model was applied to achieve the objective. It was established that women receive limited sponsorship and only in some facets of this career mentoring function thus they are left to face many difficulties as they try to climb the career ladder. The conclusion was that women working in Kenyan universities should get holistic sponsorship within mentorship if they are to advance to top leadership positions in the universities. The recommedation was that structures be set up in universities so that women get not only informal but formal mentorship, inclusive of the career function of mentorship. These structures should as well be provided in other organizations in the country. Keywords: Mentorship, Sponsorship, Women’s leadership advancement.
BEHIND THE SCENES: SPOUSAL COPING FOLLOWING PERMANENTLY DISABLING INJURY OF FARMERS

Hidden within the pastoral setting of rural America are the struggles of farm families who must cope with a decreasing economy, increasing technology, and one of the highest injury rates of any industry. Wives of farmers often juggle household responsibilities, hold an off-farm job, and work on the farm. Too often, wives are first on the scene of a serious injury to their spouses. All attention is focused on the farmer but the wife must cope with caregiving, her usual work, and the added full responsibility of the farm. This grounded theory study examined the process of spousal coping after a permanently disabling injury occurred to their farmer husbands. Interviews conducted with 12 farm wives elicited four themes in the coping process. These findings may help identify critical points of mental stress and form interventions to assist spouses of injured farmers in their adjustment to changing roles and responsibilities.
Covariates missing by design: comparison of the efficient score to other weighted methods

This paper addresses the modelling of missing covariate data with the logistic regression model. The aim of this paper is to evaluate the properties of an efficient score for logistic regression in a two‐phase design. Simulation studies show that the efficient score is more efficient than two other pseudo‐likelihood methods when the correlation between the missing covariate and its surrogate is high or the sampling proportion is small. These methods are illustrated with data from the National Wilms Tumor Study Group. Results from the example confirm the simulation study findings with the exception that the pseudo‐likelihood approach produces more reliable estimates than the weighted pseudo‐likelihood approach. Copyright © 2006 John Wiley & Sons, Ltd.
Use of social media at work: a new form of employee voice?

Social media such as Twitter and Facebook have become some of the most powerful communication tools both inside and outside of the workplace. While much of the focus has been on the potential negative and destructive (‘dark’) consequences of social media at work, less attention has been given to the harnessing of social media in a constructive (‘smart’) way to enhance human resource management (HRM). In the context of this special issue on technology and HRM, this paper takes an exploratory approach to examine the relationships between social media use and job satisfaction using data from the Australian Electronic Workplace Survey. We find that the level of job satisfaction is a factor in the desire to use social media to voice concerns related to work, but this effect is only found for Generation Y employees. However, we find social media is not commonly used to voice concerns related to work and this suggests that it is an untapped resource which could provide management with an immediate or ‘real’-time understanding of workplace issues.
Association between serum total antioxidant status and flow-mediated dilation in patients with systemic lupus erythematosus: an observational study

Objective: Endothelial dysfunction (ED) is a condition that involves increased oxidative stress and decreased total antioxidant status (TAS) levels. Systemic lupus erythematosus (SLE) is also associated with ED. We aimed to determine the association between serum TAS and ED as assessed by flow-mediated dilation (FMD) in patients with SLE. Methods: Thirty-four patients with stable SLE who were not undergoing any treatment and 39 healthy volunteers without any overt cardiovascular disease were included in this cross-sectional study. Doppler ultrasound was used to measure FMD to assess ED in the study groups. Serum TAS levels were measured using a TAS kit. High-sensitivity C-reactive protein (hs-CRP) and anticardiolipin antibody (aCLA) levels were also measured to assess the inflammatory state. The SLE group further was divided into 2 groups according to presence or absence of aCLA. SLE disease activity was assessed using the SLE disease activity index (SLEDAI). Regression analysis was used to define independent predictors. Results: The mean TAS levels were significantly lower in patients with SLE than in controls (1.60±0.11 versus 1.73±0.15 mmol/L, p<0.001). hs-CRP levels were significantly higher in patients with SLE than in controls (8.2±6.0 vs. 2.9±4.0 mg/L; p<0.001), particularly in SLE patients with positive aCLA when compared with SLE patients with negative aCLA (13.8±4.3 vs. 5.6±4.8 mg/L, p<0.001). The FMD percent was significantly lower in patients with SLE than in controls (8.1±4.9 vs. 10.6±4.7, p=0.04). There was a significant positive correlation between FMD and TAS in the SLE group (r=0.448, p=0.008) and the control group (r=0.367, p=0.03) and a significant negative correlation between FMD and serum hs-CRP (r=-0.368, p=0.04) in only the SLE group. In multiple linear regression analysis, TAS, hs-CRP and SLEDAI were independently correlated with FMD (ß=0.50, p=0.003; ß=-0.33, p=0.03; and ß=-0.36, p=0.03; respectively). Conclusion: Patients with SLE who have no overt cardiovascular disease are at increased risk for ED and this may be associated with underlying inflammation and impairment of TAS.
Multiband High-Gain Printed Yagi Array Using Square Spiral Ring Metamaterial Structures for S-Band Applications

This letter presents the design, implementation, and measured results of a novel multiband square spiral ring (SSR) metamaterial-embedded printed Yagi antenna array for WiFi, Bluetooth, WLAN, and WiMAX applications. High gain is achieved in the S-band, at four distinct frequencies. It is achieved as a result of simultaneous excitations of segments of the SSR metamaterial, coupling from dipole elements, and by arranging the proposed Yagi antenna in an array of two elements using a Wilkinson power divider. Parametric analysis of unit-cell SSR metamaterial is done in CST, and controlling of frequency resonances in the desired bands is achieved by tuning specific SSR metamaterial geometrical parameters. Proposed antennas are fabricated, and the measured gain and S11 response results are presented and compared to the simulated results for demonstrating performance of the proposed Yagi antennas and accuracy of the simulated results.
The Soybean Stem Growth Habit Gene Dt1 Is an Ortholog of Arabidopsis TERMINAL FLOWER11[W][OA]

Classical genetic analysis has revealed that the determinate habit of soybean (Glycine max) is controlled by a recessive allele at the determinate stem (Dt1) locus. To dissect the molecular basis of the determinate habit, we isolated two orthologs of pea (Pisum sativum) TERMINAL FLOWER1a, GmTFL1a and GmTFL1b, from the soybean genome. Mapping analysis indicated that GmTFL1b is a candidate for Dt1. Despite their high amino acid identity, the two genes had different transcriptional profiles. GmTFL1b was expressed in the root and shoot apical meristems (SAMs), whereas GmTFL1a was mainly expressed in immature seed. The GmTFL1b transcript accumulated in the SAMs during early vegetative growth in both the determinate and indeterminate lines but thereafter was abruptly lost in the determinate line. Introduction of the genomic region of GmTFL1b from the indeterminate line complemented the stem growth habit in the determinate line: more nodes were produced, and flowering in the terminal raceme was delayed. The identity between Dt1 and GmTFL1b was also confirmed with a virus-induced gene silencing experiment. Taken together, our data suggest that Dt1 encodes the GmTFL1b protein and that the stem growth habit is determined by the variation of this gene. The dt1 allele may condition the determinate habit via the earlier loss in GmTFL1b expression concomitant with floral induction, although it functions normally under the noninductive phase of flowering. An association test of DNA polymorphisms with the stem growth habit among 16 cultivars suggested that a single amino acid substitution in exon 4 determines the fate of the SAM after floral induction.
The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype

Objectives Obesity is a risk factor for the development of osteoarthritis (OA) in hands and knees. Adipose tissue can secrete different adipokines with powerful immunomodulatory effects. The infrapatellar fat pad (IFP) is an intra-articular organ in the vicinity of the synovium and cartilage. It is hypothesised that IFP-derived soluble factors could contribute to pathological processes in the knee joint. A study was therefore undertaken to compare the release of inflammatory mediators in the IFP and subcutaneous adipose tissue (ScAT) and to characterise the adipocytes and immune cell infiltrate in these tissues. Methods Paired IFP and ScAT samples were obtained from 27 patients with primary OA. The stromal vascular cell fraction (SVF) was isolated and characterised by fluorescence activated cell sorting. Cytokine and adipokine release in fat- and adipocyte-conditioned media was measured by luminex. Results IFP secreted higher levels of inflammatory mediators such as interleukin 6 (IL-6), adipsin, adiponectin and visfatin than ScAT. This could be due to differences in the phenotype of adipocytes and/or in the composition and phenotype of the SVF cells. IFP adipocyte-conditioned media showed a trend towards more IL-6 and adipsin than ScAT. Moreover, the SVF fraction of IFP contained more cells/g tissue, a lower percentage of T cells and a higher percentage of mast cells than ScAT. In addition, T cells had a predominantly pro-inflammatory phenotype while macrophages had a mixed pro- and anti-inflammatory phenotype in the IFP. Conclusion There are profound differences in secreted inflammatory factors and immune cell composition between the IFP and ScAT. These data indicate that IFP-derived soluble mediators could contribute to pathophysiological processes in the OA knee joint.
Clinical and pathophysiological aspects of inhibin.

Inhibin is a peptide hormone normally produced by the ovary. We have previously reported that serum inhibin concentrations are elevated in patients with granulosa cell tumours of the ovary. The aim of this study was to measure serum inhibin in a prospective, consecutive series of 200 patients admitted for suspected ovarian cancer. The serum inhibin radioimmunoassay had a sensitivity of 77 mu/l. The median effective dose was 640 mu/l, while within- and between-assay coefficients of variation in the region of maximal assay precision were 4.3% and 4.3%, respectively. The average effective doses (10 and 90%) in 35 consecutive assays were 211 and 1908 mu/l, respectively. We designated a serum inhibin concentration of > or = 130 mu/l as pathological in castrate or functionally agonadal women. Serum inhibin concentrations were elevated in 12 of 13 post-menopausal patients with mucinous cystadenocarcinoma of the ovary. By contrast, elevated serum inhibin values were found in only nine of 65 women with non-mucinous epithelial ovarian cancers. All patients showed a fall in serum inhibin levels to below 130 mu/l by 1 week after surgery. In post-menopausal women (n = 54) with proven ovarian cancer, serum inhibin concentrations correlated negatively with serum FSH and the clinical stage of their disease (P < 0.05). By contrast, serum inhibin correlated positively with serum oestradiol and progesterone (P < 0.001) but there was no correlation between serum inhibition and serum CA-125 values. We conclude that serum inhibin concentrations are typically elevated in patients proven to have mucinous cystadenocarcinoma of the ovary. (ABSTRACT TRUNCATED AT 250 WORDS)