Miracle-dz/UniFAR-FTUs huggingface dataset:
Query performance prediction for entity retrieval

We address the query-performance-prediction task for entity retrieval; that is, retrieval effectiveness is estimated with no relevance judgements. First we show how to adapt state-of-the-art query-performance predictors proposed for document retrieval to the entity retrieval domain. We then present a novel predictor that is based on the cluster hypothesis. Evaluation performed with the INEX entity ranking track collections shows that our predictor can often outperform the most effective predictors we experimented with.
Prognostic Value of the CHADS2 Score for Adverse Cardiovascular Events in Coronary Artery Disease Patients Without Atrial Fibrillation—A Multi‐Center Observational Cohort Study

Background The CHADS 2 score has mainly been used to predict the likelihood of cerebrovascular accidents in patients with atrial fibrillation. However, increasing attention is being paid to this scoring system for risk stratification of patients with coronary artery disease. We investigated the value of the CHADS 2 score in predicting cardiovascular/cerebrovascular events in coronary artery disease patients without atrial fibrillation. Methods and Results This was a multicenter, observational cohort study. The subjects had been admitted to one of the participating institutions with coronary artery disease requiring percutaneous coronary intervention. We calculated the CHADS 2 scores for 7082 patients (mean age, 69.7 years; males, 71.9%) without clinical evidence of atrial fibrillation. Subjects were subdivided into low‐ (0–1), intermediate‐ (2–3), and high‐score (4–6) groups and followed for 1 year. The end point was a composite of cardiovascular/cerebrovascular death, nonfatal myocardial infarction, and ischemic stroke at 1‐year follow‐up. Rates of triple‐vessel/left main trunk disease correlated positively with CHADS 2 score categories. CHADS 2 scores among single, double, and triple‐vessel/left main trunk groups were 2 (1–2), 2 (1–3), and 2 (2–3), respectively (P<0.001). A total of 194 patients (2.8%) had a cardiovascular/cerebrovascular event, and Kaplan–Meier analysis demonstrated a significantly higher probability of cardiovascular/cerebrovascular events in proportion to a higher CHADS 2 score (log‐rank test, P<0.001). Multivariate Cox hazard analysis identified CHADS 2 score (per 1 point) as an independent predictor of cardiovascular/cerebrovascular events (hazard ratio, 1.31; 95% CI, 1.17–1.47; P<0.001). Conclusions This large cohort study indicated that the CHADS 2 score is useful for the prediction of cardiovascular/cerebrovascular events in coronary artery disease patients without atrial fibrillation.
Biochemical and molecular changes associated with heteroxylan biosynthesis in Neolamarckia cadamba (Rubiaceae) during xylogenesis

Wood, derived from plant secondary growth, is a commercially important material. Both cellulose and lignin assembly have been well studied during wood formation (xylogenesis), but heteroxylan biosynthesis is less well defined. Elucidation of the heteroxylan biosynthetic pathway is crucial to understand the mechanism of wood formation. Here, we use Neolamarckia cadamba, a fast-growing tropical tree, as a sample to analyze heteroxylan formation at the biochemical and molecular levels during wood formation. Analysis of the non-cellulosic polysaccharides isolated from N. cadamba stems shows that heteroxylans dominate non-cellulosic polysaccharides and increase with xylogenesis. Microsomes isolated from stems of 1-year-old N. cadamba exhibited UDP-Xyl synthase and xylosyltransferase activities with the highest activity present in the middle and basal stem regions. To further understand the genetic basis of heteroxylan synthesis, RNA sequencing (RNA-seq) was used to generate transcriptomes of N. cadamba during xylogenesis. The RNA-seq results showed that genes related to heteroxylan synthesis had higher expression levels in the middle and basal part of the stem compared to the apical part. Our results describe the heteroxylan distribution and heteroxylan synthesis trait in N. cadamba and give a new example for understanding the mechanism of heteroxylan synthesis in tropical tree species in future.
Dynamical Analysis of Regulatory Interactions in the Gap Gene System of Drosophila melanogaster

Genetic studies have revealed that segment determination in Drosophila melanogaster is based on hierarchical regulatory interactions among maternal coordinate and zygotic segmentation genes. The gap gene system constitutes the most upstream zygotic layer of this regulatory hierarchy, responsible for the initial interpretation of positional information encoded by maternal gradients. We present a detailed analysis of regulatory interactions involved in gap gene regulation based on gap gene circuits, which are mathematical gene network models used to infer regulatory interactions from quantitative gene expression data. Our models reproduce gap gene expression at high accuracy and temporal resolution. Regulatory interactions found in gap gene circuits provide consistent and sufficient mechanisms for gap gene expression, which largely agree with mechanisms previously inferred from qualitative studies of mutant gene expression patterns. Our models predict activation of Kr by Cad and clarify several other regulatory interactions. Our analysis suggests a central role for repressive feedback loops between complementary gap genes. We observe that repressive interactions among overlapping gap genes show anteroposterior asymmetry with posterior dominance. Finally, our models suggest a correlation between timing of gap domain boundary formation and regulatory contributions from the terminal maternal system.
Self-similarity through high-variability: statistical analysis of Ethernet LAN traffic at the source level

A number of empirical studies of traffic measurements from a variety of working packet networks have demonstrated that actual network traffic is self-similar or long-range dependent in nature-in sharp contrast to commonly made traffic modeling assumptions. We provide a plausible physical explanation for the occurrence of self-similarity in local-area network (LAN) traffic. Our explanation is based on convergence results for processes that exhibit high variability and is supported by detailed statistical analyzes of real-time traffic measurements from Ethernet LANs at the level of individual sources. This paper is an extended version of Willinger et al. (1995). We develop here the mathematical results concerning the superposition of strictly alternating ON/OFF sources. Our key mathematical result states that the superposition of many ON/OFF sources (also known as packet-trains) with strictly alternating ON- and OFF-periods and whose ON-periods or OFF-periods exhibit the Noah effect produces aggregate network traffic that exhibits the Joseph effect. There is, moreover, a simple relation between the parameters describing the intensities of the Noah effect (high variability) and the Joseph effect (self-similarity). An extensive statistical analysis of high time-resolution Ethernet LAN traffic traces confirms that the data at the level of individual sources or source-destination pairs are consistent with the Noah effect. We also discuss implications of this simple physical explanation for the presence of self-similar traffic patterns in modern high-speed network traffic.
Effect of service sire on litter size traits in Czech Large White and Landrace pigs.

The proportion of variance for service sire effect was estimated for three litter size traits (numbers of piglets born, born alive, and weaned) in Czech Large White (89 231 litters) and Czech Landrace (28 320 litters) pigs. Each trait in the first parity was considered as one trait and that trait in the second and subsequent parities was treated as a repeated trait. Consequently, three two-trait animal models were evalu- ated for each litter size trait: (i) the service sire effect was included and the complete relationship matrix for all the animals (service sires and sows) was taken into account; (ii) the service sire effect was included as a random effect without inclusion of the relationship matrix; (iii) the service sire effect was omitted from the model. Using the residual variance as a criterion, both models including the service sire effect were slightly better than the model without this effect. Estimates of genetic parameters were very similar for the two models including the service sire effect. The proportion of variance for service sire was in the range from 2 to 3% (standard error approx. 0.2%) in Czech Large White and 2% (standard error approx. 0.3%) in Czech Landrace for all three litter size traits and all models. Models without service sire effect or models including service sire as a simple random effect and without inclusion of the genetic relationship matrix are recom- mended for genetic evaluation of litter size traits.
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome

Apert syndrome (AS) is characterized by craniosynostosis (premature fusion of cranial sutures) and severe syndactyly of the hands and feet. Two activating mutations, Ser-252 → Trp and Pro-253 → Arg, in fibroblast growth factor receptor 2 (FGFR2) account for nearly all known cases of AS. To elucidate the mechanism by which these substitutions cause AS, we determined the crystal structures of these two FGFR2 mutants in complex with fibroblast growth factor 2 (FGF2) . These structures demonstrate that both mutations introduce additional interactions between FGFR2 and FGF2, thereby augmenting FGFR2–FGF2 affinity. Moreover, based on these structures and sequence alignment of the FGF family, we propose that the Pro-253 → Arg mutation will indiscriminately increase the affinity of FGFR2 toward any FGF. In contrast, the Ser-252 → Trp mutation will selectively enhance the affinity of FGFR2 toward a limited subset of FGFs. These predictions are consistent with previous biochemical data describing the effects of AS mutations on FGF binding. Alterations in FGFR2 ligand affinity and specificity may allow inappropriate autocrine or paracrine activation of FGFR2. Furthermore, the distinct gain-of-function interactions observed in each crystal structure provide a model to explain the phenotypic variability among AS patients.
Semantic Search of Services

This paper addresses semantic search of Web services using natural language processing. First we survey various existing approaches, focusing on the fact that the expensive costs of current semantic annotation frameworks result in limited use of semantic search for large scale applications. We then propose a service search framework based on the vector space model to combine the traditional frequency weighted term-document matrix, the syntactical information extracted from a lexical database and a dependency grammar parser. In particular, instead of using terms as the rows in a term-document matrix, we propose using synsets from WordNet to distinguish different meanings of a word under different contexts as well as clustering different words with similar meanings. Also based on the characteristics of Web services descriptions, we propose an approach to identifying semantically important terms to adjust weightings. Our experiments show that our approach achieves its goal well.
Plasmid-Encoded asp Operon Confers a Proton Motive Metabolic Cycle Catalyzed by an Aspartate-Alanine Exchange Reaction

ABSTRACT Tetragenococcus halophila D10 catalyzes the decarboxylation of l-aspartate with nearly stoichiometric release of l-alanine and CO2. This trait is encoded on a 25-kb plasmid, pD1. We found in this plasmid a putative asp operon consisting of two genes, which we designated aspD and aspT, encoding an l-aspartate-β-decarboxylase (AspD) and an aspartate-alanine antiporter (AspT), respectively, and determined the nucleotide sequences. The sequence analysis revealed that the genes of the asp operon in pD1 were in the following order: promoter → aspD → aspT. The deduced amino acid sequence of AspD showed similarity to the sequences of two known l-aspartate-β-decarboxylases from Pseudomonas dacunhae and Alcaligenes faecalis. Hydropathy analyses suggested that the aspT gene product encodes a hydrophobic protein with multiple membrane-spanning regions. The operon was subcloned into the Escherichia coli expression vector pTrc99A, and the two genes were cotranscribed in the resulting plasmid, pTrcAsp. Expression of the asp operon in E. coli coincided with appearance of the capacity to catalyze the decarboxylation of aspartate to alanine. Histidine-tagged AspD (AspDHis) was also expressed in E. coli and purified from cell extracts. The purified AspDHis clearly exhibited activity of l-aspartate-β-decarboxylase. Recombinant AspT was solubilized from E. coli membranes and reconstituted in proteoliposomes. The reconstituted AspT catalyzed self-exchange of aspartate and electrogenic heterologous exchange of aspartate with alanine. Thus, the asp operon confers a proton motive metabolic cycle consisting of the electrogenic aspartate-alanine antiporter and the aspartate decarboxylase, which keeps intracellular levels of alanine, the countersubstrate for aspartate, high.
A new maximum likelihood blood velocity estimator incorporating spatial and temporal correlation

The blood flow in the human cardiovascular system obeys the laws of fluid mechanics. Investigation of the flow properties reveals that a correlation exists between the velocity in time and space. The possible changes in velocity are limited, since the blood velocity has a continuous profile in time and space. This paper presents a new estimator (STC-MLE), which incorporates the correlation property. It is an expansion of the maximum likelihood estimator (MLE) developed by Ferrara et al. With the MLE a cross-correlation analysis between consecutive RF-lines on complex form is carried out for a range of possible velocities. In the new estimator an additional similarity investigation for each evaluated velocity and the available velocity estimates in a temporal (between frames) and spatial (within frames) neighborhood is performed. An a priori probability density term in the distribution of the observations gives a probability measure of the correlation between the velocities. Both the MLE and the STC-MLE have been evaluated on simulated and in-vivo RF-data obtained from the carotid artery. Using the MLE 4.1% of the estimates deviate significantly from the true velocities, when the performance is evaluated on the simulated data. These deviating estimates arise, as the search range in the correlation analysis exceeds one wavelength. By performing a similar investigation with the STC-MLE, no highly deviating estimates occur. The allowed search range is therefore larger with the STC-MLE. The performance evaluation on in-vivo data further reveals that the number of highly deviating velocity estimates in the tissue parts of the RF-signals are reduced with the STC-MLE. In general the resulting profiles are continuous and more consistent with the true velocity profile, and the introduction of the correlation property has improved the estimates.
Analysis of isokinetic muscle function and postural control in individuals with intermittent claudication

BACKGROUND: Intermittent claudication (IC) is a debilitating condition that mostly affects elderly people. IC is manifested by a decrease in ambulatory function. Individuals with IC present with motor and sensory nerve dysfunction in the lower extremities, which may lead to deficits in balance. OBJECTIVE: This study aimed to measure postural control and isokinetic muscle function in individuals with intermittent claudication. METHOD: The study included 32 participants of both genders, 16 IC participants (mean age: 64 years, SD=6) and 16 healthy controls (mean age: 67 years, SD=5), which were allocated into two groups: intermittent claudication group (ICG) and control group (CG). Postural control was assessed using the displacement and velocity of the center of pressure (COP) during the sensory organization test (SOT) and the motor control test (MCT). Muscle function of the flexor and extensor muscles of the knee and ankle was measured by an isokinetic dynamometer. Independent t tests were used to calculate the between-group differences. RESULTS: The ICG presented greater displacement (p =0.027) and speed (p =0.033) of the COP in the anteroposterior direction (COPap) during the MCT, as well as longer latency (p =0.004). There were no between-group differences during the SOT. The ICG showed decreased muscle strength and power in the plantar flexors compared to the CG. CONCLUSION: Subjects with IC have lower values of strength and muscle power of plantiflexores, as well as changes in postural control in dynamic conditions. These individuals may be more vulnerable to falls than healthy subjects.
Nuclear pore proteins are involved in the biogenesis of functional tRNA.

Los1p and Pus1p, which are involved in tRNA biogenesis, were found in a genetic screen for components interacting with the nuclear pore protein Nsp1p. LOS1, PUS1 and NSP1 interact functionally, since the combination of mutations in the three genes causes synthetic lethality. Pus1p is an intranuclear protein which exhibits a nucleotide‐specific and intron‐dependent tRNA pseudouridine synthase activity. Los1p was shown previously to be required for efficient pre‐tRNA splicing; we report here that Los1p localizes to the nuclear pores and is linked functionally to several components of the tRNA biogenesis machinery including Pus1p and Tfc4p. When the formation of functional tRNA was analyzed by an in vivo assay, the los1(‐) pus1(‐) double mutant, as well as several thermosensitive nucleoporin mutants including nsp1, nup116, nup133 and nup85, exhibited loss of suppressor tRNA activity even at permissive temperatures. These data suggest that nuclear pore proteins are required for the biogenesis of functional tRNA.
A Multilevel Analysis of Rumor Transmission: Effects of Anxiety and Belief in Two Field Experiments

Researchers have generally reported a positive linear relation between rumor anxiety and transmission but less consistent effects of situational anxiety and belief in the rumor. These conclusions, however, are based on relatively few studies that have only analyzed between-subject variance in rumor transmission and often in situations producing only moderate anxiety. We examined rumors stemming from 2 real-world settings: (a) the sudden death of a college student from meningitis and (b) the Washington, DC "sniper" shootings. We analyzed data using multilevel modeling and focused primarily on within-subjects variance. In both studies, we found strong overall effects of belief and typically no overall effect of rumor anxiety. More important, in both studies, a significant Belief × Anxiety interaction occurred. In contrast to past theorizing, the effects of belief were strongest for high-anxiety rumors. Also interesting was a significant curvilinear effect of anxiety at lower levels of belief in Study 1 and a significant main effect of situational anxiety in Study 2.We discuss the important contribution that multilevel modeling can make to the growing literature on rumor transmission.
ERA VACCINE-DERIVED CASES OF RABIES IN WILDLIFE AND DOMESTIC ANIMALS IN ONTARIO, CANADA, 1989–2004

A vaccination program for the control of terrestrial rabies in the province of Ontario, Canada, began in 1989. During the period between 1989 and 2004, over 13 million baits containing the live, attenuated rabies virus ERA-BHK21 were distributed across the province, with the aim of immunizing foxes by the oral route. Animals recovered from bait distribution areas were assayed by fluorescent antibody test for rabies virus infection. Immunoreactivity with a panel of monoclonal antibodies that discriminate between ERA and rabies virus variants known to circulate in Ontario, and molecular genetic analyses were used to identify animals infected with ERA. Nine cases of ERA variant rabies were identified over the 16-yr period of study; these did not appear to be stratified by species, year of discovery, or location of capture. The ERA-positive animals were found across the province in eight counties, all of which had been baited in the year of case discovery. The nine ERA-positive cases included four red foxes (Vulpes vulpes), two raccoons (Procyon lotor), two striped skunks (Mephitis mephitis), and one bovine calf (Bos taurus). Molecular phylogenetic analyses of the partial N gene sequences generated from these isolates indicated that these nine cases were due to infection with the ERA variant. The glycoprotein sequences were predicted from G gene sequencing of all nine field isolates and two laboratory stock ERA viruses. This revealed some heterogeneity at residue 120 (either arginine or histidine) in both field and laboratory stocks as well as a few other mutations in field isolates. The significance of this heterogeneity remains unclear. Our data demonstrate that the ERA vaccine distributed in Ontario carried residual pathogenicity; however, there does not appear to be any evidence of ERA establishment in wildlife populations over the 16-yr period. These results are consistent with previous reports of the rare detection of ERA vaccine–induced rabies and with laboratory studies of ERA pathogenicity.
But is it byllying? : teaching positive relationships to young children

Introduction How to use this book Section 1 - Name-calling Further activities Research related activity Section 2 - Teasing Further activities Research related activity Section 3 - Physically Hurting People's Bodies Further activities Research related activity Section 4 - Verbal Bullying Further activities Research related activity Section 5 - Taking, Breaking and Threatening Further activities Research related activity Section 6 - Excluding Further activities Research related activity Summary Checklist Part 1 Checklist Part 2 Story picture-books Resources
Most Discriminative Primitive Selection for Identity Determination Using Handwritten Devanagari Script

Writer recognition based on peculiarity of hand-writing is an important aspect of any forensic analysis. We present an approach for selecting best discriminative primitives for writer recognition. After selecting the primitives we also propose a hybrid system by combining both writer recognition and handwriting recognition for improved accuracy. We have also validated the performance of selected primitives on publically available dataset. We have performed this study on the Devanagri script. Experimental results verified the effectiveness of the proposed franework.