Miracle-dz/UniFAR-FTUs huggingface dataset:
Implementing the least-price Cloud Storage Service in Multiple Cloud Providers

Many cloud master groups (CSPs) outfit statistics amassing corporations with datacenters unfold round the field. These datacenters bring numerous get/put latencies and unit fees for resource make use of and reservation. It is important for cloud gain vendors to offer a multi-conveyed ability enterprise to confine their portion fee to cloud pro workplaces (CSPs) whilst giving company diploma goal (SLO) confirmation to their customers. Different multi-allotted parking space organizations were proposed or component esteem minimization or SLO guarantee. In the following paper, we initiate a multi-cloud Economical and SLO-guaranteed Storage Service (ES3), which is heading off to a craving substances challenge and helpful asset reservation plans with parcel cost minimization and SLO ensure. ES3 joins (1) a prepared substances circulation and asset reservation strategy, which allocates each datum component to a data center and goes to a longing the advantage reservation sum on datacenters with the manual of making use of the greater part of the looking at methodologies (2) an inherited be counted essentially based totally insights project exchange approach, which diminish measurements Get/Put fee variance in each datacenter to construct the reservation select up. We other than propose several estimations to update the value incredible and SLO guarantee execution of ES3 involving I) dynamic demand redirection, ii) amassed Gets for expense diminish, iii) continuous fortify for charge compelling Puts, and iv) synchronous deals for unbending Get SLO guarantee.
A New Analytical Formula for Coupling Capacitance of Unipolar Capacitive Coupler in Wireless Power Transfer System

In this research, using response surface methodology (RSM), an analytical formula as functional dependencies on the six specified geometrical parameters is developed for coupling capacitance (Cm) of a capacitive power transfer (CPT) device. The geometrical parameters include the physical and misalignment parameters of the plates. Using the variance analysis, the sensitivity of the Cm value to variations in the geometric parameters of the CPT device was investigated. The established analytical formula allows for easy calculation of the Cm value specific to the CPT devices for their different geometric parameters, including for different misalignments. It is also particularly useful in optimal design of the CPT devices. However, it was found that the misalignment parameters have a negligible effect on the Cm. On the other hand, the physical parameters have an effect of 46%, 38%, and 16% for the transmitter plate area, receiver plate area, and air-gap between them, respectively.
Biomechanical Analysis of a prosthetic foot Bioc-dm2

Introduction: Human walk is one of the aspects directly compromising human wellbeing, as it has a physical and emotional impact in daily life. For this study, we delve into the challenge of improving some walking conditions in a patient suffering lower limb loss, specifically at transtibial or transfemoral levels. Given that our purpose was the analysis, design and manufacture of a lower-limb prosthetic component, which fills the needs for functionality, it became necessary to build a foot with all the quality standards associated to each and all movements required to form the complex fundamental pattern of walk. Besides, this foot should also easily endure weight, daily use and physical characteristics of the patient object of this study. On the other hand, it is feasible that design and verification of the component provided a competitive element, as compared to existing elements currently in the market. The previous situation generated the need for verification from the National Institute for Medications and Food (INVIMA), as well as the revision of the use replying device, for component verification, in accordance with ISO 10328
B-ICP: Backpressure Interest Control Protocol for Multipath Communication in NDN

Named Data Networking (NDN) is a promising communication paradigm to support content distribution for the Future Internet. The objective of this paper is to maximize the consumer downloading rate by retrieving content via multiple paths concurrently. This is supported by adaptive forwarding in NDN. The majority of solutions for selecting the forwarding interfaces do so based on latency. However, this can overload the low-latency paths quickly. This can occur as users reduce requesting rates based on congestion signals, from the low-latency paths. Hence, the high-latency paths are not fully utilized. This paper solves this problem by introducing Backpressure Interest Control Protocol (B-ICP). In B-ICP, routers estimate the forwarding capabilities of interfaces based on congestion signals and limit the forwarding rates to interfaces accordingly. Thus, B-ICP avoids congesting certain paths earlier than others, with the aim being evenly distributed path utilization. Simulation-based evaluations show that B-ICP improves throughput, converges to equilibriums quickly and supports the producers that join the network dynamically in comparison with existing solutions.
Base-specific mutational intolerance near splice sites clarifies the role of nonessential splice nucleotides

Variation in RNA splicing (i.e., alternative splicing) plays an important role in many diseases. Variants near 5′ and 3′ splice sites often affect splicing, but the effects of these variants on splicing and disease have not been fully characterized beyond the 2 “essential” splice nucleotides flanking each exon. Here we provide quantitative measurements of tolerance to mutational disruptions by position and reference allele-alternative allele combination. We show that certain reference alleles are particularly sensitive to mutations, regardless of the alternative alleles into which they are mutated. Using public RNA-seq data, we demonstrate that individuals carrying such variants have significantly lower levels of the correctly spliced transcript compared to individuals without them, and confirm that these specific substitutions are highly enriched for known Mendelian mutations. Our results propose a more refined definition of the “splice region” and offer a new way to prioritize and provide functional interpretation of variants identified in diagnostic sequencing and association studies.
Fluid flow induces Rankl expression in primary murine calvarial osteoblasts

Mechanical loading of bone generates fluid flow within the mineralized matrix that exerts fluid shear stress (FSS) on cells. We examined effects of FSS on receptor activator of nuclear factor κ B ligand (RANKL), a critical factor for osteoclast formation. Primary murine osteoblasts were subjected to pulsatile FSS (5 Hz, 10 dynes/cm2) for 1 h and then returned to static culture for varying times (post‐FSS). Protein levels were measured by Western analysis and mRNA by Northern analysis, RT‐PCR and quantitative PCR. There were 20‐ to 40‐fold increases in RANKL mRNA at 2–4 h post‐FSS. RANKL protein was induced by 2 h post‐FSS and remained elevated for at least 8 h. Effects were independent of cyclooxygenase‐2 activity. Small increases (up to three‐fold) in mRNA of the decoy receptor for RANKL, osteoprotegerin, were seen. Five min of FSS, followed by static culture, was as effective in stimulating RANKL mRNA as 4 h of continuous FSS. FSS induced cAMP activity, and H‐89, a protein kinase A (PKA) inhibitor, blocked the FSS induction of RANKL. H‐89 also inhibited the PKC pathway, but specific PKC inhibitors, GF109203X and Go6983, did not inhibit FSS‐induced RANKL. FSS induced phosphorylation of ERK1/2, and PD98059, an inhibitor of the ERK pathway, inhibited the FSS induction of RANKL mRNA 60%–90%. Thus, brief exposure to FSS resulted in sustained induction of RANKL expression after stopping FSS, and this induction was dependent on PKA and ERK signaling pathways. Increased RANKL after mechanical loading may play a role in initiating bone remodeling. J. Cell. Biochem. 98: 1271–1283, 2006. © 2006 Wiley‐Liss, Inc.
E-Health Monitoring by Smart Pulse Oximeter Systems Integrated in SDU

This paper presents the software and hardware architecture of the e-health smart pulse oximeter system integrated into SDU (Seat Display Unit) for passengers’ surveillance in-flight. The purpose of the smart system comes from the knowledge that during the flight, the inside cab conditions, such as low pressure, lack of oxygen and low humidity are risk factors in patients suffering from chronic obstructive pulmonary disease (BPOC), cardiovascular diseases, venous thrombosis, asthma, lung emphysema, surgical operations suffered recently, epilepsy, diabetes, mental diseases and infectious diseases. Monitoring of oxygen levels in the blood and pulse rate during the phases such as takeoff/flight/landing might provide valuable information on the health status of passengers and subsequently, this information could be used in the medical field to make recommendations to patients who have specific ailments and to travel by air. According to recent studies, during the flight cabins are pressurized to 75% of normal atmospheric pressure and low levels of oxygen in the blood may lead to hypoxia, a deficiency in the quantity of oxygen to reach the tissues. Moreover, the reduced pressure in the cab and lack of oxygen may endanger the life of the patients that suffer from chronic obstructive pulmonary disease (BPOC).
A Novel Protection Strategy for Elastic Optical Networks Based on Space Division Multiplexing

The emergence of elastic optical networks (EONs) has been viewed as a solution to the diverse bandwidth requests that will occur in the next generation's network applications and Internet which are anticipated to handle a traffic growth at a rate greater than Petabit per second level. However, the crunch in fiber capacity will persist owing to use of only two dimensions of multiplexing in the EONs. With the adoption of space division multiplexing (SDM), an extra freedom degree can be used such that the EONs will be able support the required capacity of the future diverse traffic. Further, with an increase in the rate(s) of transmission(s), to counter the network failures, there will occur the need for protection mechanisms, specifically those, which can protect routes and provision solutions which are end-to-end. In the current work, as an intial step for protecting an EON based on SDM, we design a strategy which (i) is independent of the failure(s), and (ii) protects the route(s). We evaluate our proposed strategy considering realistic assumptions, topologies and parameters, and for different traffic load values. The obtained simulation results reveal that (i) our proposed strategy is efficient in provisioning of protection which is pre-configured, and (ii) the considered network topology's node degree significantly affects both, the blocking and the evaluated route's length in the protected EON based on SDM.
The contribution of mouse models to the understanding of constitutional thrombocytopenia

Constitutional thrombocytopenias result from platelet production abnormalities of hereditary origin. Long misdiagnosed and poorly studied, knowledge about these rare diseases has increased considerably over the last twenty years due to improved technology for the identification of mutations, as well as an improvement in obtaining megakaryocyte culture from patient hematopoietic stem cells. Simultaneously, the manipulation of mouse genes (transgenesis, total or conditional inactivation, introduction of point mutations, random chemical mutagenesis) have helped to generate disease models that have contributed greatly to deciphering patient clinical and laboratory features. Most of the thrombocytopenias for which the mutated genes have been identified now have a murine model counterpart. This review focuses on the contribution that these mouse models have brought to the understanding of hereditary thrombocytopenias with respect to what was known in humans. Animal models have either i) provided novel information on the molecular and cellular pathways that were missing from the patient studies; ii) improved our understanding of the mechanisms of thrombocytopoiesis; iii) been instrumental in structure-function studies of the mutated gene products; and iv) been an invaluable tool as preclinical models to test new drugs or develop gene therapies. At present, the genetic determinants of thrombocytopenia remain unknown in almost half of all cases. Currently available high-speed sequencing techniques will identify new candidate genes, which will in turn allow the generation of murine models to confirm and further study the abnormal phenotype. In a complementary manner, programs of random mutagenesis in mice should also identify new candidate genes involved in thrombocytopenia.
Enhancing the Unified Logical Effort algorithm for branching and load distribution

In this paper, the authors proposed a novel technique to calculate the capacitance distribution and branching effort of a multiple fan-out logic path for equal propagation delay in each path regardless of number of gates and lengths of the wire segments in those logic path. The authors utilize the prior methods for the Unified Logical Effort (ULE) methodology as the basis of delay estimation and transistor sizing for the work of this paper. The runtime for fan-out of 2 is logarithmic in n or O(log2(n)), where n is the precision index. Several examples are also analyzed and detailed using the proposed algorithm showing how the branching effort can easily be calculated in the presence of a complex circuit tree with arbitrary loading.
Research on frequency conversion PLL for three-phase unbalanced and harmonic power system

In the new energy power generation, software phase locked loop is an important part of the grid connected converter. In the unbalanced and harmonic power system, the accuracy and speed of traditional phase locked loop is unable to meet the needs of high performance converter at the same time. The frequency conversion PLL based on frequency conversion filter and amplitude phase compensation precisely extracts grid fundamental positive sequence component. The accuracy and speed of PLL has been significantly improved although the grid suffers unbalance, distortion, and phase or frequency mutation. The method can completely filter out the interference signal with different amplitude without changing the parameters. Accuracy will not be reduced due to the increase of unbalanced or harmonic content of the three-phase power grid. So it avoids the mutual restriction between the phase lock accuracy and the phase lock speed, and owns nice dynamic response speed and simple parameter design process. In a variety of grid environments, Simulation and experimental results show that frequency conversion PLL is able to track the grid phase in the poor power grid. Also, it ensures normal operation of grid connected converter when there is power grid failure or mutation.
Transient complement inhibition plus T-cell immunosuppression induces long-term survival of mouse-to-rat cardiac xenografts.

BACKGROUND The use of anti-B-cell and T-cell immunosuppressive agents leads to only a few weeks' survival of mouse-to-rat cardiac xenografts. METHODS BALB/c cardiac xenografts were transplanted to Lewis rats treated with cyclosporine (CsA) and/or cobra venom factor (CVF). RESULTS CsA alone did not prolong xenograft survival (2.2+/-0.4 days), whereas CVF alone led to minimal prolongation of survival (5.6+/-0.8 days) as compared with nontreated recipients (2.4+/-0.5 days). The combination of CsA plus CVF, the latter given for either 2 days or 11 days, resulted in long-term survival of 14/16 hearts (> 100 days). Production of IgM elicited xenoreactive antibodies (EXA) peaked on day 4 after transplantation and decreased thereafter. Production of IgG EXA occurred only in the control group, whereas, in the CsA/CVF-treated group, IgG EXA were totally suppressed. Long-term surviving grafts showed (i) excellent preservation of morphology and minimal leukocyte infiltration, (ii) deposition of IgM, IgG and weak C3 deposition on the graft endothelium, (iii) low level infiltration by rat macrophages, (iv) replacement of mouse dendritic cells by class II+ rat macrophages, and (v) expression within endothelial and smooth muscle cells, macrophages, and myocytes of HO-1, a "protective gene" not seen in the rejected hearts. CONCLUSIONS Our present findings suggest that long-term mouse-to-rat cardiac xenograft survival is induced by temporary suppression of C activation and sustained T-cell suppression leading to inhibition of IgG EXA production. Florid expression of a protective gene (HO-1) may contribute to survival.
Effect of heat-moisture treatment on resistant starch functional and thermal properties of mung bean (vigna radiate) starch

The formulation of well-designed food products always being a very interesting sector in food science and technology. Based on the data stated by World Health Organization [1], diabetic patients have been risen from 108 million in 1980 to 422 million in 2014 leading to the cause of major deaths in 2030. Starch is considered as a significant carbohydrate for human regime existing due to its high source of energy. Since starch is very easily digestible in small intestine and causes increment of blood glucose level, its consumption is very much detrimental for diabetes and obsessed patients. Consequently, it is abundant task to frame food products which can imitate with fiber materials. Resistant starch (RS) is getting acceptance among several food scientists and manufacturers [2]. RS, the starch fraction which is not digestible in smaller intestine and can be fermented through microflora in colon, lowering down its pH and prevents causes of colon cancer The valuable result of RS has been concise by several authors, which inhibits colon cancer, reduces insulin emic reaction to food, a valuable medium for the microorganisms in the intestine, preventive against formation of stones in gall bladder, controls higher cholesterol development, regulates fat accretion, and helps in assimilation of minerals [3]. Therefore RS can be an alternative approach for production of new, innovative functional food products especially for diabetes and obsessed individuals.
Application of denoising algorithm based on LPSO-WNN in speech recognition

This paper introduces an intelligent evaluation method based on improved PSO-WNN (partiele swarm optimization-wavelet neural network) for speech denoising in high background noise. Firstly, by using Lyapunov stability theory, the convergence conditions for single particle in PSO algorithm are discussed and a new strategy based on the result is introduced to improve the performance of PSO algorithm. Then, LPSO-WNN is introduced, in which the improved PSO algorithm is used to optimize the parameters of WNN. Finally, the trained LPSO-WNN is used to identify and recognition the speech signal in high background noise. Experimental results show that the new method is high efficient and practicable for filtering the high background noise and recognition the speech signal.
Physical activity status of academic professors during their early career transition: An application of the theory of planned behavior

Life-transitions (e.g. parenthood) have been linked to physical inactivity, yet the topic requires further exploration. In this study, we evaluated changes in the physical activity (PA) of adults during their early career transition using retrospective analysis and the theory of planned behavior. Recruitment from January to March 2010 yielded a random sample of 267 assistant professors, ages 25–44, employed within the last five years. Repeated measures analysis of variance (RM ANOVA) concluded that PA declined across the transition (d = 0.36–0.43) and was further attenuated by marriage, work hours, and parenthood status. Discriminant function analysis (DFA) identified specific behavioral and control correlates about PA enjoyment, limited time, inconsistent schedule, work demands, and job pressures to distinguish between those who remained active from those who did not across the transition. PA interventions administered prior to career transitions may be needed to prevent physical inactivity.
Critical parameters affecting the design of high frequency transmission lines in standard CMOS technology

Different structures of transmission lines were designed and fabricated in standard CMOS technology to estimate some critical parameters including the RMS value of the surface roughness and the loss tangent. The input impedances for frequencies up to 50 GHz were modeled and compared with measurements. The results demonstrated a strong correlation between the used model with the proposed coefficients and the measured results, attesting the robustness of the model and the reliability of the incorporated coefficients values.
Comparison of the Convolution algorithm with TMR10 for Leksell Gamma knife and dosimetric verification with radiochromic gel dosimeter

Abstract The Convolution algorithm, implemented in Leksell GammaPlan® ver. Here, 10, is the first algorithm for Leksell Gamma Knife that takes heterogeneities into account and models dose build‐up effects close to tissue boundaries. The aim of this study was preliminary comparison of the Convolution and TMR10 algorithms for real clinical cases and dosimetric verification of the algorithms, using measurements in a phantom. A total of 25 patients involved in comparison of the Convolution and TMR10 algorithms were divided into three groups: patients with benign tumors close to heterogeneities, patients with functional disorders, and patients with tumors located far from heterogeneities. Differences were observed especially in the group of patients with tumors close to heterogeneities, where the difference in maximal dose to critical structures for the Convolution algorithm was up to 15% compared to the TMR10 algorithm. Dosimetric verification of the algorithm was performed, using a radiochromic gel dosimeter based on Turnbull blue dye in a special heterogeneous phantom. Relative dose distributions measured with the radiochromic gel dosimeter agreed very well with both the TMR10 and Convolution calculations. We observed small discrepancies in the direction in which the largest inhomogeneity was positioned. Verification results indicated that the Convolution algorithm provides a different dose distribution, especially in regions close to heterogeneities and particularly for lower isodose volumes. However, the results obtained with gamma analyses in the gel dosimetry experiment did not verify the assumption that the Convolution algorithm provides more accurate dose calculation.