Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores

Objective To develop and validate two new fracture risk algorithms (QFractureScores) for estimating the individual risk of osteoporotic fracture or hip fracture over 10 years. Design Prospective open cohort study with routinely collected data from 357 general practices to develop the scores and from 178 practices to validate the scores. Setting General practices in England and Wales. Participants 1 183 663 women and 1 174 232 men aged 30-85 in the derivation cohort, who contributed 7 898 208 and 8 049 306 person years of observation, respectively. There were 24 350 incident diagnoses of osteoporotic fracture in women and 7934 in men, and 9302 incident diagnoses of hip fracture in women and 5424 in men. Main outcome measures First (incident) diagnosis of osteoporotic fracture (vertebral, distal radius, or hip) and incident hip fracture recorded in general practice records. Results Use of hormone replacement therapy (HRT), age, body mass index (BMI), smoking status, recorded alcohol use, parental history of osteoporosis, rheumatoid arthritis, cardiovascular disease, type 2 diabetes, asthma, tricyclic antidepressants, corticosteroids, history of falls, menopausal symptoms, chronic liver disease, gastrointestinal malabsorption, and other endocrine disorders were significantly and independently associated with risk of osteoporotic fracture in women. Some variables were significantly associated with risk of osteoporotic fracture but not with risk of hip fracture. The predictors for men for osteoporotic and hip fracture were age, BMI, smoking status, recorded alcohol use, rheumatoid arthritis, cardiovascular disease, type 2 diabetes, asthma, tricyclic antidepressants, corticosteroids, history of falls, and liver disease. The hip fracture algorithm had the best performance among men and women. It explained 63.94% of the variation in women and 63.19% of the variation in men. The D statistic values for discrimination were highest for hip fracture in women (2.73) and men (2.68) and were over twice the magnitude of the corresponding values for osteoporotic fracture. The ROC statistics for hip fracture were also high: 0.89 in women and 0.86 for men versus 0.79 and 0.69, respectively, for the osteoporotic fracture outcome. The algorithms were well calibrated with predicted risks closely matching observed risks. The QFractureScore for hip fracture also had good performance for discrimination and calibration compared with the FRAX (fracture risk assessment) algorithm. Conclusions These new algorithms can predict risk of fracture in primary care populations in the UK without laboratory measurements and are therefore suitable for use in both clinical settings and for self assessment (www.qfracture.org). QFractureScores could be used to identify patients at high risk of fracture who might benefit from interventions to reduce their risk.
Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components.

Transforming growth factor (TGF)-beta-induced chondrogenesis of mesenchymal stem cells derived from bone marrow involves the rapid deposition of a cartilage-specific extracellular matrix. The sequential events in this pathway leading from the undifferentiated stem cell to a mature chondrocyte were investigated by analysis of key matrix elements. Differentiation was rapidly induced in cells cultured in the presence of TGF-beta 3 or -beta 2 and was accompanied by the early expression of fibromodulin and cartilage oligomeric matrix protein. An increase in aggrecan and versican core protein synthesis defined an intermediate stage, which also involved the small leucine-rich proteoglycans decorin and biglycan. This was followed by the appearance of type II collagen and chondroadherin. The pathway was also characterized by the appearance of type X collagen, usually associated with hypertrophic cartilage. There was also a change in the pattern of sulfation of chondroitin sulfate, with a progressive increase in the proportion of 6-sulfated species. The major proportion of newly synthesized glycosaminoglycan was part of an aggregating proteoglycan network. These data allow us to define the phenotype of the differentiated cell and to understand in greater detail the sequential process of matrix assembly.
A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3

The use of small molecules to ‘chemically direct’ differentiation represents a powerful approach to promote specification of embryonic stem cells (ESCs) towards particular functional cell types for use in regenerative medicine and pharmaceutical applications. Here, we demonstrate a novel route for chemically directed differentiation of human ESCs (hESCs) into definitive endoderm (DE) exploiting a selective small-molecule inhibitor of glycogen synthase kinase 3 (GSK-3). This GSK-3 inhibitor, termed 1m, when used as the only supplement to a chemically defined feeder-free culture system, effectively promoted differentiation of ESC lines towards primitive streak (PS), mesoderm and DE. This contrasts with the role of GSK-3 in murine ESCs, where GSK-3 inhibition promotes pluripotency. Interestingly, 1m-mediated induction of differentiation involved transient NODAL expression and Nodal signalling. Prolonged treatment of hESCs with 1m resulted in the generation of a population of cells displaying hepatoblast characteristics, that is expressing α-fetoprotein and HNF4α. Furthermore, 1m-induced DE had the capacity to mature and generate hepatocyte-like cells capable of producing albumin. These findings describe, for the first time, the utility of GSK-3 inhibition, in a chemically directed approach, to a method of DE generation that is robust, potentially scalable and applicable to different hESC lines.
Service innovation for e-government: a broadband-based example

This paper investigates the relationship between broadband and service innovation in an e-government context. We ask, what characterises successful broadband-based service innovation projects in the public sector? The research approach is a quantitative survey in a large public broadband diffusion initiative in Norway. The paper offers three conclusions. First, broadband-based service innovation is seen as a two-step process; first a technologically oriented project, followed by an organisational implementation. The focus of the project manager should be on the second of the phases, not the first. Second, the engagement of a professional external project manager does not support service innovation. The reason is that the external project manager lacks the necessary local knowledge and alliances with central stakeholders. Third, traditional project management is not well suited to understand and manage service innovation. Our contribution is aimed at the e-government research community, but our conclusions are also relevant for project managers and public sector managers.
The grieving process in separation and divorce

Separation and divorce involves great loss. The grieving process associated with divorce is complex and one that is generally not well understood. While there are many parallels with bereavement, there are also fundamental differences. This article discusses the distinctive features of grief in divorce, and focuses on four main aspects including different experiences of the initiator and non-initiator; negative redefinition of other; ongoing connections between former partners and the heightened role of anger. The impact of practical, material aspects is also highlighted. How former partners deal with these elements largely determines longer term outcomes.
Low-complexity distributed fault detection for wireless sensor networks

To guarantee its integrity, a wireless sensor network needs to efficiently detect faulty nodes producing erroneous measurements. This paper proposes a fully distributed fault detection algorithm. A node first collects the measurements of its neighborhood, processes them to decide whether they contain outliers, and broadcasts the result. Then, it decides autonomously about its functioning status. The detection algorithm is proposed in two variants, depending on the proportion of faulty nodes in the network. A theoretical analysis of the probability of error and of the convergence of the algorithm is provided. The tradeoff between false alarm probability and detection probability is characterized using simulation.
Attitudes of professional anatomists to curricular change

Throughout the world, recent developments in medical curricula have led to marked changes in the teaching of gross anatomy. This change has involved decreasing curricular student contact time and the use of new methods for anatomical teaching. Some “modern” anatomists have welcomed the arrival of these novel methods while other, more “traditional,” anatomists have fought to maintain the use of cadaveric dissection. Consequently, controversy over teaching methods has developed to the point that “modernist” and “traditionalist” views within the community of professional anatomists seem to have diverged such that the importance of gross anatomy in the medical curriculum is disputed and that cadaveric dissection by students is no longer the preferred method of teaching. This study tests this hypothesis using Thurstone and Chave attitude analyses to assess attitudes to educational change and the importance of anatomy in medicine and a matrix questionnaire that required professional anatomists to relate course aims to different teaching methods. In total, 112 completed questionnaires were received from anatomists who are employed at higher education institutions that use various teaching methods and who span the academic hierarchy. The results suggest that over 90% of anatomists favor educational change and ∼98% of professional anatomists believe that gross anatomy has an important role to play in clinical medicine. A clear majority of the anatomists (69%) favored the use of human cadaveric dissection over other teaching methods (this method seeming to achieve a range of different course aims/objectives) (P < 0.001; Kruskal–Wallis). Using Kruskal–Wallis statistical tests, the order‐of‐preference for teaching methods was found to be as follows: 1 Practical lessons using cadaveric dissection by students 2 Practical lessons using prosection 3 Tuition based upon living and radiological anatomy 4 Electronic tuition using computer aided learning (CAL) 5 Didactic teaching alone (e.g. lectures/class room‐based tuition) 6 Use of models The preference for the use of human cadaveric dissection was evident in all groups of anatomists, whether “traditionalist” or “modernist” (P = 0.002, Chi‐squared). These findings are therefore not consistent with our initial hypothesis. Clin. Anat. 19:132–141, 2006. © 2005 Wiley‐Liss, Inc.
TSPC Flip-Flop circuit design with three-independent-gate silicon nanowire FETs

True Single-Phase Clock (TSPC) Flip-Flops, based on dynamic logic implementation, are area-saving and high-speed compared to standard static flip-flops. Furthermore, logic gates can be embedded into TSPC flip-flops which significantly improves performance. As a promising approach to keep the pace of Moore's Law, functionality-enhanced devices with multiple independent gates have drown many recent interests. In particular, Three-Independent-Gate Silicon Nanowire FETs (TIG SiNWFETs) can realize the functionality of two serial transistors in a single device. Therefore, they open new opportunities to compact designs in both arithmetic and control circuits. In this paper, we propose TSPC flip-flop implementation with asynchronous set and reset using the compactness of TIG SiNWFET. Electrical simulations show that TIG SiNWFET-based TSPC flip-flop improves nearly 20%, 30% and 7% in area, delay and leakage power respectively as compared to its LSTP FinFET counterpart at 22nm.
A Network Topology Control and Identity Authentication Protocol with Support for Movable Sensor Nodes

It is expected that in the near future wireless sensor network (WSNs) will be more widely used in the mobile environment, in applications such as Autonomous Underwater Vehicles (AUVs) for marine monitoring and mobile robots for environmental investigation. The sensor nodes’ mobility can easily cause changes to the structure of a network topology, and lead to the decline in the amount of transmitted data, excessive energy consumption, and lack of security. To solve these problems, a kind of efficient Topology Control algorithm for node Mobility (TCM) is proposed. In the topology construction stage, an efficient clustering algorithm is adopted, which supports sensor node movement. It can ensure the balance of clustering, and reduce the energy consumption. In the topology maintenance stage, the digital signature authentication based on Error Correction Code (ECC) and the communication mechanism of soft handover are adopted. After verifying the legal identity of the mobile nodes, secure communications can be established, and this can increase the amount of data transmitted. Compared to some existing schemes, the proposed scheme has significant advantages regarding network topology stability, amounts of data transferred, lifetime and safety performance of the network.
Semi-Automatic Vortex Extraction in 4D PC-MRI Cardiac Blood Flow Data using Line Predicates

Cardiovascular diseases (CVD) are the leading cause of death worldwide. Their initiation and evolution depends strongly on the blood flow characteristics. In recent years, advances in 4D PC-MRI acquisition enable reliable and time-resolved 3D flow measuring, which allows a qualitative and quantitative analysis of the patient-specific hemodynamics. Currently, medical researchers investigate the relation between characteristic flow patterns like vortices and different pathologies. The manual extraction and evaluation is tedious and requires expert knowledge. Standardized, (semi-)automatic and reliable techniques are necessary to make the analysis of 4D PC-MRI applicable for the clinical routine. In this work, we present an approach for the extraction of vortex flow in the aorta and pulmonary artery incorporating line predicates. We provide an extensive comparison of existent vortex extraction methods to determine the most suitable vortex criterion for cardiac blood flow and apply our approach to ten datasets with different pathologies like coarctations, Tetralogy of Fallot and aneurysms. For two cases we provide a detailed discussion how our results are capable to complement existent diagnosis information. To ensure real-time feedback for the domain experts we implement our method completely on the GPU.
Child-centred education: preschool teachers’ beliefs and self-reported practices

This study analyses the beliefs and self-reported practices of preschool teachers with regard to the concept of child-centred education, as well as the consistency between these beliefs and practices. Data were collected via interviews with 20 female teachers employed in public preschools in Ankara, Turkey. The results indicated that the participants’ beliefs and practices related to developmental domains were not consistent with child-centred education, whereas their beliefs and practices involving the physical environment of the classroom, instructional activities, relationships, behaviour management, assessment, and parental involvement were partially consistent with it. Congruence between beliefs and practices in the sphere of child-centred education was strongest with respect to developmental domains and less strong in the other areas studied.
Insuring the Integrity and Validity of Social Work Interventions: The Case of the Subsidized Guardianship Waiver Experiments

The near loss of the ability to conduct randomized controlled trials in the Title IV-E waiver demonstrations makes the negotiation of a ceasefire urgent in the “causal wars. ” Results-oriented accountability is a conceptual framework for managing the micro–macro tensions that arise in social work practice and research. This article uses subsidized guardianship experiments to illustrate the results-oriented accountability process by which innovation is aggregated from the micro level through formative implementation and evaluation into a usable, stable intervention that can be rigorously tested through summative implementation and evaluation at the macro level, and if validated, generalized to the micro level through translative implementation and evaluation.
Lipid disorders in hospital attendants in Kumasi, Ghana.

BACKGROUND Lipid disorders are common worldwide and contribute to a significant proportion of the burden of atherosclerotic cardiovascular diseases. OBJECTIVES To determine the prevalence of lipid disorders among patients reporting at Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana. DESIGN Cross-sectional study. SETTING Directorate of Medicine and Polyclinic outpatient clinics of KATH. PARTICIPANTS A total of 424 patients, 20 years and over reporting for the first time to KATH were recruited. 77 had neither diabetes mellitus (DM) nor systemic hypertension (HPT) (controls), 94 had only DM, 109 had only HPT and 144 had both. METHODS A questionnaire was administered after informed consent. Anthropometric measurements were then taken and blood investigations including total cholesterol (TC), high-density lipoprotein cholesterol (HDL) and triglycerides (TG) were done. Low-density lipoprotein cholesterol (LDL) was calculated using the Friedwald formula. The atherogenic index or ratio was the ratio of TC to HDL. RESULTS The prevalence of lipid abnormalities was 60% for high TC, 32% for high TG, 17% for low HDL and 61% for high LDL. The mean (± standard deviation) TC was 5.33 (± 1.31) mmol/L, mean TG was 1.52 (± 0.81) mmol/L, mean HDL was 1.65 (± 0.57) mmol/L and mean LDL was 3.42 (± 1.22) mmol/L. The mean atherogenic index was 3.40 and 9% of the participants had an atherogenic index more than or equal to 5. CONCLUSION The prevalence of lipid disorders was high in adult patients in Kumasi and there is the need to increase awareness, screening, detection, treatment and control of these disorders.
Improving generative statistical parsing with semi-supervised word clustering

We present a semi-supervised method to improve statistical parsing performance. We focus on the well-known problem of lexical data sparseness and present experiments of word clustering prior to parsing. We use a combination of lexicon-aided morphological clustering that preserves tagging ambiguity, and unsupervised word clustering, trained on a large unannotated corpus. We apply these clusterings to the French Treebank, and we train a parser with the PCFG-LA unlexicalized algorithm of (Petrov et al., 2006). We find a gain in French parsing performance: from a baseline of F1=86.76% to F1=87.37% using morphological clustering, and up to F1=88.29% using further unsupervised clustering. This is the best known score for French probabilistic parsing. These preliminary results are encouraging for statistically parsing morphologically rich languages, and languages with small amount of annotated data.
[Prevalence of trachoma in Brazilian schoolchildren].

OBJECTIVE To estimate the prevalence and describe the distribution of trachoma among schoolchildren in Brazilian municipalities. METHODS Cross-sectional study, using cluster sampling, of the schoolchildren population of the Brazilian municipalities with Human Development Index - Municipal lower than the national average. This trachoma prevalence survey was conducted by the Ministry of Health, in the period 2002-2007. There were 119,531 schoolchildren selected from 2,270 schools located in 1,156 municipalities. The selected schoolchildren underwent an external ocular examination, with a magnifying glass (2.5X), to detect clinical signs of trachoma according to the WHO criteria. The prevalence of trachoma, by state and national level, and their respective 95% confidence intervals were estimated. Chi-square and Chi-square for trends tests were used to compare categorical variables. RESULTS There were 6,030 cases of trachoma detected, resulting in a prevalence of 5.0% (95%CI 4.5;5.4). There was no significant difference between the sexes. The prevalence of trachoma was 8.2% among children under 5 years of age, decreasing among higher age groups (p < 0.01). There was a significant difference in prevalence between urban and rural areas, 4.3% versus 6.2% respectively (p < 0.01). Cases were detected in 901 municipalities (77.7% of the sample), in all regions of the country. In 36.8% of the selected municipalities, the prevalence was higher than 5%. CONCLUSIONS The study shows that trachoma is a significant public health problem in Brazil, contradicting the belief that the disease had been controlled in the country. The survey provides a baseline for evaluating planned interventions aimed at achieving the goal of global certification of elimination of trachoma as a cause of blindness in Brazil by 2020.
Predicting two facets of social verticality in meetings from five-minute time slices and nonverbal cues

This paper addresses the automatic estimation of two aspects of social verticality (status and dominance) in small-group meetings using nonverbal cues. The correlation of nonverbal behavior with these social constructs have been extensively documented in social psychology, but their value for computational models is, in many cases, still unknown. We present a systematic study of automatically extracted cues - including vocalic, visual activity, and visual attention cues - and investigate their relative effectiveness to predict both the most-dominant person and the high-status project manager from relative short observations. We use five hours of task-oriented meeting data with natural behavior for our experiments. Our work suggests that, although dominance and role-based status are related concepts, they are not equivalent and are thus not equally explained by the same nonverbal cues. Furthermore, the best cues can correctly predict the person with highest dominance or role-based status with an accuracy of 70% approximately.
Improving the use of advisor networks for multi-agent trust modelling

This paper provides an approach for improving the trust modelling of users when a social network of advisors is employed (for example when advisors are recommending the most trustworthy service providers). We present three important improvements to trust modelling, two directly relating to the size of the network (through either the use of a threshold or by setting a maximum network size) and a third (advisor referrals) which focuses on ensuring that the advisors have attained an appropriate level of expertise, for the advice that they provide. Experimental results confirm the value of our methods when choosing parameters in a principled manner, leading to improvements in the accuracy of trust modelling (shown in the context of electronic marketplaces). In all, this research provides insights into how to set the size and composition of social networks, in order to effectively integrate the advice of peers when modelling the trust of users.