Miracle-dz/UniFAR-FTUs huggingface dataset:
The Optical Spectrum of a Large Isolated Polycyclic Aromatic Hydrocarbon: Hexa-peri-hexabenzocoronene, C42H18

The first optical spectrum of an isolated polycyclic aromatic hydrocarbon large enough to survive the photophysical conditions of the interstellar medium is reported. Vibronic bands of the first electronic transition of the all-benzenoid polycyclic aromatic hydrocarbon hexa-peri-hexabenzocoronene were observed in the 4080-4530 Å range by resonant 2-color 2-photon ionization spectroscopy. The strongest feature at 4264 Å is estimated to have an oscillator strength of f = 1.4 × 10−3, placing an upper limit on the interstellar abundance of this polycyclic aromatic hydrocarbon at 4 × 1012 cm−2, accounting for a maximum of ~0.02% of interstellar carbon. This study opens up the possibility to rigorously test neutral polycyclic aromatic hydrocarbons as carriers of the diffuse interstellar bands in the near future.
Comparison of the Abbott IMx® and a High-Performance Liquid Chromatography Method for Measuring Total Plasma Homocysteine

Abstract The determination of the total concentration of plasma homocysteine is of interest in a variety of clinical circumstances, especially, in the evaluation of the risk of cardiovascular disease. However, most of the methods available to date, many of them chromatographic, are not well suited for the majority of clinical laboratories. Several automated methods are now or will be, shortly, commercially available. We have compared one of them, the fluorescence polarization immunoassay (FPIA) adapted to the IMx® analyzer (Abbott Laboratories), with the high-performance liquid chromatography (HPLC) method with fluorescent detection currently used in our laboratory. The results show that the FPIA-IMx® method is less imprecise and slightly more sensitive than the HPLC. The comparison of 67 clinical plasma specimens indicated that there is a proportional error disagreement between FPIA-IMx® and HPLC (FPIA=1.19 HPLC + 0.92; confidence region for slope and y-intercept were, respectively, from 1.06 to 1.31 and from−0.06 to 2.32). The nature of this error is not explained by the experiments performed to study the inaccuracy of both methods, which included the investigation of dilution parallelism, analytical recovery and cross-reactivity. The different results of homocysteine concentration obtained with FPIA-IMx® and HPLC must be taken into account when a change of methodology is under consideration.
Automatic segmentation of therapeutic exercises motion data based on a predictive event approach

This paper presents a predictive event approach which is applied for automatic segmentation of therapeutic exercise sequences. The main purpose of our study is to enhance the efficiency of movement analysis in patients with neurological disorders. When dealing with analysis of rehabilitation exercises it is often required to pre-process the collected data. In order to examine the movements and to carry out the relevant measurements and determine the parameters of interest, each movement must be segmented from a given sequence and analyzed separately. More generally, in case of gesture recognition tasks, after gesture acquisition, segmentation is the following and central step, which can have a huge impact on the classification rate of the gesture recognition system. Gesture segmentation and recognition systems have significant applications in many different fields such as virtual and augmented reality [1], industrial process control [2], physical rehabilitation [3], human-robot interaction [4], computer games [5] etc. Due to this, gesture segmentation is an active research topic and challenging scientific problem, fairly present in the latest research. The predictive event approach is based on a principle of detecting an event when sensor data depart significantly from an adaptive model-based predictor. We have used portable, low-cost Kinect device with marker-free based technique. During exercise execution, the skeleton is continuously detected and 3D positions of characteristic human joints are collected for each frame (Fig. 2). From the original data set, which consists of all collected joints motion data, we have extracted the ones from interest for upper body movement therapeutic exercises (hand and elbow joint). Trajectories of selected joints are modelled as Gaussian processes. Based on this data set, a Gaussian process based predictor is adapted and used to detect significant changes in the exercise sequences. The results over the formed dataset are compared with commonly used technique and illustrate the superiority of our approach.
Cross-Sectional Associations Between Measures of Sleep and Markers of Glucose Metabolism Among Subjects With and Without Diabetes

OBJECTIVE To examine whether sleep duration and quality are associated with fasting glucose, fasting insulin, or estimated insulin resistance in a community-based sample of early middle-aged adults. RESEARCH DESIGN AND METHODS This was an ancillary study to the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Habitual sleep duration and fragmentation were estimated from 6 days of wrist actigraphy collected in 2003–2005. Insomnia was defined as self-reported difficulty falling asleep or waking up in the night three or more times per week plus average sleep efficiency of <80% based on actigraphy. Fasting blood samples to measure glucose and insulin were collected after the sleep measures during the CARDIA clinical examination in 2005–2006. Insulin resistance was estimated using the homeostatic model assessment (HOMA) method. Analyses were cross-sectional and stratified by the presence of diabetes. RESULTS There was no association between sleep measures and fasting glucose, insulin, or HOMA in the 115 subjects without diabetes. Among the 40 subjects with diabetes, after adjustment for covariates, 10% higher sleep fragmentation was associated with a 9% higher fasting glucose level, a 30% higher fasting insulin level, and a 43% higher HOMA level. Insomnia was associated with a 23% higher fasting glucose level, a 48% higher fasting insulin level, and an 82% higher HOMA level. CONCLUSIONS The observed association between poor sleep quality and higher glucose, insulin, and estimated insulin resistance among subjects with diabetes warrants further examination of the effect of sleep disturbances on glucose control in type 2 diabetes.
Challenges of a Hidden Epidemic: HIV Prevention Among Women in the United States

HIV/AIDS trends in the United States depict a concentrated epidemic with hot spots that vary by location, poverty, race/ethnicity, and transmission mode. HIV/AIDS is a leading cause of death among US women of color; two-thirds of new infections among women occur in black women, despite the fact that black women account for just 14% of the US female population. The gravity of the HIV epidemic among US women is often not appreciated by those at risk and by the broader scientific community. We summarize the current epidemiology of HIV/AIDS among US women and discuss clinical, research, and public health intervention components that must be brought together in a cohesive plan to reduce new HIV infections in US women. Only by accelerating research and programmatic efforts will the hidden epidemic of HIV among US women emerge into the light and come under control.
Modeling the Internet Routing Topology – In Less than 24h

In this paper, we outline a fast approach to build a model of the Internet’s AS-level routing topology. More important than the construction process itself is the detailed analysis of the model’s accuracy by comparing it against a vast amount of routing table data. This analysis allows researchers to evaluate whether the model itself is accurate enough for their own evaluation purposes, i.e. how well it reflects today’s routing topology, information most models to date lack. We further utilize the modeling process to evaluate today’s routing topology’s quality using the AS path length as a metric. With the modeling process automated, we perform this analysis and produce a new model once a month and make it available online. This continuous monitoring of the Internet’s routing topology will not only provide us with constant updates on the Internet’s current state but will over time give us a better understanding of the Internet routing system’s evolution.
Cause and Circumstance of In-Hospital Mortality Among Patients Undergoing Contemporary Percutaneous Coronary Intervention: A Root-Cause Analysis

Background— Prior studies suggest that most deaths in patients undergoing percutaneous coronary intervention (PCI) are related to procedural complications. Mortality associated with PCI has steadily declined during the past decade, and the cause and circumstance of death among patients undergoing PCI in the contemporary era remain unknown. Methods and Results— We evaluated all patients undergoing PCI at the University of Michigan from 2001 to 2009. There were 85 deaths among a total of 5520 patients undergoing PCI during this time period. By using a standardized data collection form, 3 cardiologists (2 interventional, H.S.G. and D.S.M.; 1 noninvasive, A.M.B.) determined the cause and circumstance of death, in addition to grading the preventability of death. Left ventricular failure was the most common cause of death (35.3%, n=30), followed by neurological compromise (16.5%, n=14) and arrhythmia (12.1%, n=12). The circumstance of death was mostly acute cardiac (52.9%, n=45), with a procedural complication composing a small fraction (7.1%, n=6). Reviewers determined 93% of deaths to be mostly or entirely unpreventable. Conclusions— Procedural complications are responsible for a small fraction of deaths among patients undergoing contemporary PCI. Measures to further enhance procedural safety are unlikely to translate into meaningful reductions in PCI mortality.
Improving 2D scatterplots effectiveness through sampling, displacement, and user perception

In this paper we present a novel, hybrid, and automatic strategy whose goal is to reduce the 2D scatter plot cluttering. The presented technique relies on a combination of nonuniform sampling and pixel displacement and it is driven by perceptual results coming from a suitable user study. The same results are used to define precise quality metrics that allow for validating our approach.
Performance analysis of time division broadcast protocol with incremental relaying and symmetric users

This paper investigates two‐way relaying with direct link transmission. We propose to combine incremental relaying (IR) with the time division broadcast protocol (TDBC) to form a new scheme, termed TDBC‐IR, to increase the spectral efficiency of TDBC. Assuming half‐duplex decode‐and‐forward relaying, the performance of three protocols, that is, TDBC, TDBC‐IR, and physical‐layer network coding (PNC), are studied and compared, in terms of outage probability, expected rate (ER), and diversity‐multiplexing tradeoff. First, we reveal that the outage probability performance of TDBC‐IR is the same as that of TDBC and better than that of PNC. Second, we compare the ER and diversity‐multiplexing tradeoff performance of the three protocols based on the derived outage probability. The numerical results reveal that (1) the ER of TDBC‐IR is greater than that of TDBC and PNC in the whole signal‐to‐noise ratio (SNR) region, that is TDBC‐IR has improved spectral efficiency performance; (2) the ER performance of TDBC is better than PNC in the low SNR region but worse in the high SNR region; (3) the maximum achievable diversity order of TDBC‐IR and TDBC are both two whereas that of PNC is one; (4) the maximum achievable multiplexing gain of TDBC‐IR is one, which is better than TDBC (its maximum achievable is 2/3) and achieves the maximum of PNC (its maximum achievable is one). Copyright © 2012 John Wiley & Sons, Ltd.
Antiparasitic and antiproliferative effects of indoleamine 2,3-dioxygenase enzyme expression in human fibroblasts

Studies were carried out to evaluate the proposed role of indoleamine 2,3-dioxygenase (INDO) induction in the antimicrobial and antiproliferative effects of gamma interferon (IFN-gamma) in human fibroblasts. The INDO cDNA coding region was cloned in the pMEP4 expression vector, containing the metallothionein (MTII) promoter in the sense (+ve) or the antisense (-ve) orientation. Human fibroblasts (GM637) stably transfected with the sense construct expressed INDO activity after treatment with CdCl2 or ZnSO4, but cells transfected with the antisense construct did not. The growth of Chlamydia psittaci was strongly inhibited in INDO +ve cells but not in INDO -ve cells after treatment with Cd2+ or Zn2+. The inhibition correlated with the level of INDO activity induced and could be reversed by the addition of excess tryptophan to the medium. The growth of Toxoplasma gondii was also strongly inhibited in INDO +ve cells but not in INDO -ve cells after treatment with Cd2+. Expression of Cd(2+)-induced INDO activity also inhibited thymidine incorporation and led to cytotoxicity in INDO +ve cells but not in INDO -ve cells. Thus, the induction of INDO activity by IFN-gamma may be an important factor in the antimicrobial and antiproliferative effects of IFN-gamma in human fibroblasts.
Signs and symptoms of moral injury in female vietnam veterans: A qualitative examination of the nvvrs

x INTRODUCTION . 11 METHODS . 24 Participants . 24 Design and Procedures . 25 Analysis of Data . 25 RESULTS . 28 Frequency and Extensiveness . 28 Moral Injury . 29 Research Questions . 30 DISCUSSION . 32 Limitations . 38 Directions for Future Research . 40 REFERENCES . 43 APPENDIX A: Literature Table Summary and Spreadsheets . 56 APPENDIX B: Coded Data . 105 LITERATURE TABLE REFERENCES . 114
Development of a Model Depicting Optimum Performance of Liquid Catheter Sensor for Pressure Measurement

In this paper the author proposed a model that depicts not only the basic features of liquid catheter sensor but also improvement of those features. The optimum performance of the 2nd order liquid catheter sensor system depends on parameters namely natural frequency of oscillation and damping ratio and two basic features namely high frequency response and flat frequency response. As the system dynamics of the liquid catheter sensor is evolved as closed loop transfer function therefore it is very difficult to design this system with help the of root locus method where the open loop gain is varied to estimate the behavior of the closed loop poles of the system. In this paper the author has used a novel approach of basic vector field method for two dimensional linearized systems. The model clearly indicates the optimum performance criterion of the liquid catheter sensor based on the model proposed by the author. The proposed model not only gives the various dynamic features of liquid catheter sensor but also highlights both inertia controlled and thermally controlled vapor bubble dynamics. Copyright © 2013 IFSA.
The Social Problem-solving Approach of Adolescent Females Diagnosed with an Eating Disorder :Toward a Greater Understanding of Control

The current study examined social information processing variables, social problem solving skills, and interpersonal assertiveness in adolescent females diagnosed with an eating disorder. A total of 114 adolescent females between the ages of 14-17 participated in the study. Fifty girls currently in treatment for a diagnosed eating disorder were compared to 64 healthy nonclinical controls. When presented with vignettes depicting ambiguous social dilemmas, the eating disorder group demonstrated a more hostile attributional bias, experienced a significantly greater intensity of negative emotions, and relied upon more avoidant coping strategies when compared to the nonclinical control group. Specifically, the eating disorder group reported significantly more intrapunitive avoidant strategies that represent a selfdestructive means of coping with distressing events. In addition, the eating disorder group had significantly less confidence in their ability to effectively handle social problems, and felt more overwhelmed emotionally in response to social problems. Finally, the eating disorder group reported significantly less interpersonal assertiveness, that likely impacts feelings of helplessness and loss of control in relationships. The results identified social problem-solving skill deficits that may contribute to or maintain core eating disorder pathology.
High Blood Pressure in Overweight and Obese Youth: Implications for Screening

In the absence of evidence‐based guidelines for high blood pressure screening in asymptomatic youth, a reasonable strategy is to screen those who are at high risk. The present study aimed to identify optimal body mass index (BMI) thresholds as a marker for high‐risk youth to predict hypertension prevalence. In a cross‐sectional study, youth aged 6 to 17 years (n=237,248) enrolled in an integrated prepaid health plan in 2007 to 2009 were classified according to their BMI and hypertension status. In moderately and extremely obese youth, the prevalence of hypertension was 3.8% and 9.2%, respectively, compared with 0.9% in normal weight youth. The adjusted prevalence ratios (95% confidence intervals) of hypertension for normal weight, overweight, moderate obesity, and extreme obesity were 1.00 (Reference), 2.27 (2.08–2.47), 4.43 (4.10–4.79), and 10.76 (9.99–11.59), respectively. The prevalence of hypertension was best predicted by a BMI‐for‐age ≥94th percentile. These results suggest that all obese youth should be screened for hypertension.
An on-chip TSV emulation using metal bar surrounded by metal ring to develop interface circuits

TSV is considered to be the next industry standard for chip interconnects because of huge number of I/O pins and high frequency capability. However, TSV is not readily available to develop interface circuits. An on-chip TSV emulation is presented by using a horizontal metal bar surrounded by a horizontal metal ring on a silicon chip with a 0.13-μm CMOS process. The resistance and capacitance of emulated TSVs and the substrate resistance are extracted as an HSPICE W-element model through measurements with an LCR meter and the oscillation frequency of on-chip ring oscillator. The comparison of the S-parameter measurements (transmission, crosstalk) showed good agreement between measurements and the simulation using the extracted parameters.
Antidepressant-like effect of Tagetes lucida Cav. extract in rats: involvement of the serotonergic system.

It has been demonstrated that the decoction of the aerial parts of Tagetes lucida Cav. produces an antidepressant effect during the forced swimming test (FST) in rats. The aim of this study was to evaluate the effect of different organic extracts and one aqueous extract of the aerial parts of T. lucida on the FST. In addition, the possible involvement of the serotonergic system in the antidepressant-like effect of T. lucida in the FST was evaluated, as was its potential toxicological effect. The different extracts of T. lucida (methanol, hexane, dichloromethane and aqueous, 10 and 50 mg/kg), as well as fluoxetine (FLX, 5 mg/kg), were administered per os (p.o.) to rats for 14 days. All animals were subjected to the FST. Only the aqueous extract of T. lucida at a dose of 50 mg/kg significantly reduced immobility behavior and increased swimming in the FST, similar to FLX. Later, the aqueous extract of T. lucida (50mg/kg) was administered for 1, 7 and 14 days. An antidepressant effect was observed after 7 days of treatment. To evaluate the participation of the serotoninergic system, the animals were pretreated with PCPA, an inhibitor of serotonin synthesis (100 mg/kg/day for 4 consecutive days). The animals were treated with the aqueous extract of T. lucida (50 mg/kg) and FLX (5 mg/kg) 24 h after the final injection and were then subjected to the FST. Pretreatment with PCPA inhibited the antidepressant effect of both T. lucida and FLX. Finally, T. lucida was administered p.o. and intraperitoneal route to evaluate its acute toxicological effect. The aqueous extract of T. lucida, administered p.o. , did not produce lethality or any significant changes in behavior. In conclusion, the aqueous extract of T. lucida manifested an antidepressant-like effect in the FST mediated by the serotonergic system, with no adverse effects when administered p.o.
SensorWiki.org: A Collaborative Resource for Researchers and Interface Designers

This paper describes an online Wiki, a collaborative Web site designed to allow users to edit and add content. It was created at the Input Devices and Music Interaction Laboratory with the aim of promoting and supporting the construction of new musical interfaces. Although many individual universities and research centres offer sources of relevant information online, this project allows for easy sharing and dissemination of information across institutional and international boundaries. In this paper, the internal framework and categorization scheme for the Wiki is profiled, and each section is introduced. The benefits of joining this effort are clearly demonstrated, and the possible future directions of the project are detailed.
Rab5 Association with the Angiotensin II Type 1A Receptor Promotes Rab5 GTP Binding and Vesicular Fusion*

Previous studies have demonstrated that the internalization of the angiotensin II type 1A receptor (AT1AR) may be mediated by both β-arrestin-sensitive and -insensitive mechanisms. Therefore, we have used the AT1AR carboxyl-terminal tail to screen a rat brain yeast two-hybrid expression library for novel AT1AR-interacting proteins that might contribute to the regulation of AT1AR internalization. We have identified Rab5a as an AT1AR-binding protein that selectively associates with the AT1AR and not with the β2-adrenergic receptor. A Rab5a-S34N mutant defective in GTP binding does not prevent the internalization of the AT1AR but does prevent the trafficking of the AT1AR into larger hollow cored vesicular structures. Agonist activation of the AT1AR promotes both the formation of Rab5a·AT1AR protein complexes and Rab5a GTP binding. Rab5a interactions with the AT1AR are mediated in part by the last 10 amino acid residues of the AT1AR carboxyl-terminal tail, and although a mutant receptor lacking these residues internalizes normally, it does not redistribute into larger hollow vesicles. Our data suggest that AT1AR activation modulates Rab5a activity leading to the homotypic fusion of endocytic vesicles. These observations suggest that vesicular cargo proteins, such as the AT1AR, may control their targeting between intracellular compartments by directly regulating the activity of components of the intracellular trafficking machinery such as Rab5a.
The role of intraductal ultrasonography in pancreatobiliary diseases

Intraductal ultrasonography (IDUS) provides real-time, cross-sectional imaging of pancreatobiliary ducts and surrounding structures during endoscopic retrograde cholangiopancreatography using a high-frequency ultrasound (US) transducer. Hence, IDUS has been considered a sensitive tool in the evaluation of suspicious choledocholithiasis and neoplasms, to help distinguish between benign and malignant bile duct strictures or wall thickness, and to assess tumor extension and invasion depth. With the rapid development and enriched choices of sensitive diagnostic modalities include but are not limited to endoscopic US, peroral cholangioscopy, and confocal laser endomicroscopy, it is needed to systematically assess the role of IDUS in the investigation of pancreatobiliary diseases. Some new developments and innovative use of IDUS techniques will be discussed in this paper with the review of literature.