Miracle-dz/UniFAR-FTUs huggingface dataset:
Objective and subjective socioeconomic status and health symptoms in patients following hematopoietic stem cell transplantation

Recent research indicates that subjective socioeconomic status (SES) – the perception of one's own SES compared with other people – is an important predictor of cancer‐related health outcomes. Subjective SES may function as a psychosocial mechanism by which objective SES affects health, well‐being, and, more broadly, quality of life among cancer survivors. This study tested whether the association between objective SES and indicators of quality of life was mediated by subjective SES in a sample of cancer survivors who had undergone hematopoietic stem cell transplantation.
Validation of the modified 2010 American College of Rheumatology diagnostic criteria for fibromyalgia in a Spanish population.

OBJECTIVE The aim of this study was to validate the modified 2010 ACR preliminary criteria for FM in a Spanish population. METHODS Five hundred and seventy-nine (550 women) FM and 294 (240 women) control participants were enrolled in the study. FM patients were previously diagnosed by a rheumatologist. All participants underwent both the 1990 ACR criteria (1990c) and the modified 2010 ACR criteria (m-2010c). RESULTS The tender points count showed correlations of 0.69, 0.65 and 0.71 with the widespread pain index (WPI), symptoms severity (SS) and polysymptomatic distress (PSD) scales, respectively (all P < 0.001). The WPI, SS and PSD showed greater correlations with impact of FM health-related quality of life, general fatigue and depression than the tender points count. The 1990c showed sensitivity and specificity values of 84.1 and 97.6, respectively, whereas the m-2010c showed values of 88.3 and 91.8, respectively. Both criteria showed the same overall accuracy, with a value of 0.89. When the 1990c and m-2010c were combined and patients had to satisfy one of two criteria to be diagnosed with FM, the sensitivity, specificity and accuracy of questionnaires were 96.7, 89.8 and 0.94, respectively. The original cut-off points (WPI ≥ 7, SS ≥ 5 and PSD ≥ 12) showed the best test characteristics in the present study. CONCLUSION The m-2010c, with the same cut-off points as the original version, are a valid tool for the diagnosis of FM in our population. Whenever possible, the combination of the 1990c and m-2010c is recommended (patients have to meet one of the two criteria to be diagnosed), since this approach showed the best diagnostic characteristics.
Stability of Ego Defenses and Endocrine Responses in Women Prior to Breast Biopsy and Ten Years Later

&NA; Thirty women with breast masses were evaluated psychologically and endocrinologically ten years ago while they were awaiting breast biopsy (3). Eight of these women proved to have benign fibrocystic disease and 22 had breast cancer. A significant (p < 0.05) positive correlation was found between extent of failure of psychological “defenses” and cortisol metabolite excretion rate in these 30 women. On follow‐up, 12 women had died (11 with cancer and one who had had benign disease); 7 women were lost to follow‐up. Of the remaining 11, one refused to participate, leaving 10 women for follow‐up study (7 who had had mastectomy for breast cancer and 3 with benign breast lesions). They were reevaluated using the same assessment techniques as 10 years before. The psychological parameters and cortisol metabolite excretion rates did not show a significant change over the span of ten years. These data support the hypothesis that these psychological parameters and cortisol metabolite excretion rates reflect relatively abiding characteristics and are not as much affected by a “psychosocial threat” as previous research has suggested.
Estimation of H ii Bubble Size Distribution from 21 cm Power Spectrum with Artificial Neural Networks

The bubble size distribution of ionized hydrogen regions probes information about the morphology of H II bubbles during reionization. Conventionally, the H II bubble size distribution can be derived from the tomographic imaging data of the redshifted 21 cm signal from the epoch of reionization, which, however, is observationally challenging even for upcoming large radio interferometer arrays. Given that these interferometers promise to measure the 21 cm power spectrum accurately, we propose a new method, which is based on artificial neural networks, to reconstruct the H II bubble size distribution from the 21 cm power spectrum. We demonstrate that reconstruction from the 21 cm power spectrum can be almost as accurate as being directly measured from the imaging data with fractional error ≲10%, even with thermal noise at the sensitivity level of the Square Kilometre Array. Nevertheless, the reconstruction implicitly exploits the modeling in reionization simulations, and hence the recovered H II bubble size distribution is not an independent summary statistic from the power spectrum, and should be used only as an indicator for understanding H II bubble morphology and its evolution.
mt5se: An Open Source Framework for Building Autonomous Traders

—Autonomous trading robots have been studied in artiﬁcial intelligence area for quite some time. Many AI techniques have been tested for building autonomous agents able to trade ﬁnancial assets. These initiatives include traditional neural networks, fuzzy logic, reinforcement learning but also more recent approaches like deep neural networks and deep reinforcement learning. Many developers claim to be successful in creating robots with great performance when simulating execution with historical price series, so called backtesting. However, when these robots are used in real markets frequently they present poor performance in terms of risks and return. In this paper, we propose an open source framework (mt5se) that helps the development, backtesting, live testing and real operation of autonomous traders. We built and tested several traders using mt5se. The results indicate that it may help the development of better traders. Furthermore, we discuss the simple architecture that is used in many studies and propose an alternative multiagent architecture. Such architecture separates two main concerns for portfolio manager (PM) : price prediction and capital allocation. More than achieve a high accuracy, a PM should increase proﬁts when it is right and reduce loss when it is wrong. Furthermore, price prediction is highly dependent of asset’s nature and history, while capital allocation is dependent only on analyst’s prediction performance and assets’ correlation. Finally, we discuss some promising technologies in the area.
Weighted Linear Dynamic System for Feature Representation and Soft Sensor Application in Nonlinear Dynamic Industrial Processes

Industrial process plants are instrumented with a large number of redundant sensors and the measured variables are often contaminated by random noises. Thus, it is significant to discover the general trends of data by latent variable models in the probabilistic framework before soft sensor modeling. However, traditional probabilistic latent variable models such as probabilistic principal component analysis are mostly static linear approaches. The process dynamics and nonlinearities have not been well considered. In this paper, a novel weighted linear dynamic system (WLDS) is proposed for nonlinear dynamic feature extraction. In WLDS, two kinds of weights are proposed for local linearization of the nonlinear state evolution and state emission relationships. In this way, a weighted log-likelihood function is designed and expectation-maximization algorithm is then used for parameter estimation. The feasibility and effectiveness of the proposed method is demonstrated with a numerical example and an industrial process application.
Quality of care and long-term care administrators’ education: Does it make a difference?

Background: Long-term care administrators (administrators) can influence the care nursing home residents receive. However, little research has examined what factors of administrators are associated with how they influence care. Purposes: In this research, the association between administrators’ education and quality of nursing home care is examined. In addition, the association between state educational and training requirements and quality of nursing home care is examined. Methodology: Information collected from 3,941 administrators was matched with secondary data, including Nursing Home Compare; the Online Survey, Certification and Reporting data; and the Area Resource File. The quality indicators restraint use, catheter use, inadequate pain management, low-risk residents with pressure ulcers, and high-risk residents with pressure ulcers were examined. Findings: Positive, statistically significant associations were found between the education level of administrators and all five quality indicators. Likewise, positive statistically significant associations were found between state educational requirements and state training requirements and the five quality indicators. Practice Implications: If these associations hold true, then promoting further educational attainment of individual administrators may influence quality of care. The state educational requirements and training requirements for administrators’ licensure may represent an additional means of influencing the quality of care in nursing homes.
Automatic string test data generation for detecting domain errors

Domain testing is designed to detect domain errors that result from a small boundary shift in a path domain. Although many researchers have studied domain testing, automatic domain test data generation for string predicates has seldom been explored. This paper presents a novel approach for the automatic generation of ON–OFF test points for string predicate borders, and describes a corresponding test data generator. Our empirical work is conducted on a set of programs with string predicates, where extensive trials have been done for each string predicate, and the results are analysed using the SPSS tool. Conclusions are drawn that: (i) the approach is promising and effective; (ii) there is a strong linear relationship between the performance of the test generator and the length of target string in the predicate tested; and (iii) initial inputs, no shorter than the target string and with characters generated randomly, may enhance the performance in the test data generation for string predicates. Copyright © 2009 John Wiley & Sons, Ltd.
The granin family of uniquely acidic proteins of the diffuse neuroendocrine system: comparative and functional aspects

The chromogranins A (CgA) and B (CgB) and secretogranin II (SgII) constitute the main members of a family of uniquely acidic secretory proteins in elements of the diffuse neuroendocrine system. These genetically distinct proteins, CgA, CgB, SgII and the less well known secretogranins III–VII are collectively referred to as‘granins’and characterised by numerous pairs of basic amino acids as potential cleavage sites for processing by the co‐stored prohormone converting enzymes PC 1/3 and PC2.
Divide-and-conquer crystallographic approach towards an atomic structure of intermediate filaments.

Intermediate filaments (IFs) represent an essential component of the cytoskeleton in higher eukaryotic cells. The elementary building block of the IF architecture is an elongated dimer with its dominant central part being a parallel double-stranded alpha-helical coiled coil. Filament formation proceeds via a specific multi-step association of the dimers into the unit-length filaments, which subsequently anneal longitudinally and finally radially compact into mature filaments. To tackle the challenge of a crystallographic structure determination, we have produced and characterised 17 overlapping soluble fragments of human IF protein vimentin. For six fragments ranging in length between 39 and 84 amino acid residues, conditions yielding macroscopic crystals could be established and X-ray diffraction data were collected to the highest resolution limit between 1.4 and 3 A. We expect that solving the crystal structures of these and further fragments will eventually allow us to patch together a molecular model for the full-length vimentin dimer. This divide-and-conquer approach will be subsequently extended to determining the crystal structures of a number of complexes formed by appropriate vimentin fragments, and will eventually allow us to establish the three- dimensional architecture of complete filaments at atomic resolution.
Lipopolysaccharide-induced expression of multiple alternatively spliced MEFV transcripts in human synovial fibroblasts: a prominent splice isoform lacks the C-terminal domain that is highly mutated in familial Mediterranean fever.

OBJECTIVE To investigate the expression of the familial Mediterranean fever (FMF) gene (MEFV) in human synovial fibroblasts. METHODS MEFV messenger RNA in synovial fibroblasts, chondrocytes, and peripheral blood leukocytes (PBLs) was analyzed by semiquantitative and real-time polymerase chain reaction and ribonuclease protection assay. The subcellular localization of pyrin, the MEFV product, was determined in transfected synovial fibroblasts and HeLa cells with plasmids encoding pyrin isoforms. Native pyrin was detected with an antipyrin antibody. RESULTS MEFV was expressed in synovial fibroblasts, but not in chondrocytes. Four alternatively spliced transcripts were identified: an extension of exon 8 (exon 8ext) resulting in a frameshift that predicts a truncated protein lacking exons 9 and 10, the addition of an exon (exon 4a) predicting a truncated protein at exon 5, the in-frame substitution of exon 2a for exon 2, and the previously described removal of exon 2 (exon 2Delta). Exon 8ext transcripts represented 27% of the total message population in synovial fibroblasts. All other alternatively spliced transcripts were rare. Consensus and alternatively spliced transcripts were induced by lipopolysaccharide in synovial fibroblasts and PBLs. In transfected cells, the proteins encoded by all highly expressed splice forms were cytoplasmic. In contrast, native pyrin was predominantly nuclear in synovial fibroblasts, neutrophils, and dendritic cells, but was cytoplasmic in monocytes. CONCLUSION Several MEFV transcripts are expressed and inducible in synovial fibroblasts. A prominent isoform lacks the C-terminal domain that contains the majority of mutations found in patients with FMF. While recombinant forms of all major pyrin isoforms are cytoplasmic, native pyrin is nuclear in several cell types. Thus, mechanisms in addition to splicing patterns must control pyrin's subcellular distribution.
Child Mental Health in Latin America: Present and Future Epidemiologic Research

Objective: This report reviews population studies of child and adolescent mental health carried out in Latin America over the past 15 years. Also considered is the issue of how to meet the needs of children and adolescents who may present mental health problems in Latin America, given that most of them live in poverty in economies that are underdeveloped, providing limited resources. Method: Ten studies from six different countries were identified that employed some form of randomized sampling method and used standardized instruments for assessment. The authors present a summary of the main characteristics of these studies, highlighting methodological features that may account for differences in the rates obtained. Results: Overall, a similar pattern of prevalence and risk factors for mental health problems in children and adolescents in Latin American countries emerged. Moreover, rates of disorders in these children are similar to the 15 to 20% found in other countries. These findings are similar to those observed when adult mental health problems are considered. Prevention and treatment strategies are discussed and the peculiarities of the delivery of mental health services for children and adolescents are explored. Conclusions: Future research needs to focus on understanding of resilience and formal and informal mental health delivery systems of care available in different Latin American countries. Such research has high potential for ameliorating the prevention and treatment of child and adolescent mental health problems in this region of the world.
Purinoceptors mediate renal vasodilation by nitric oxide dependent and independent mechanisms.

BACKGROUND Adenosine triphosphate (ATP) and its metabolites including adenosine modulate renal vascular tone under physiological and pathophysiological conditions. Their effects are brought about by activation of membrane bound P1- and P2-purinoceptors located on smooth muscle and endothelial cells. In this study we analyzed the purinoceptor mediated dilation of rabbit and human renal arteries, and evaluated the possible involvement of endothelium-derived relaxing factors. METHODS Segments of rabbit and human renal arteries were incubated and perfused with medium containing indomethacin. After preconstriction, drug induced changes in the vessel diameters were measured by a photoelectric device. RESULTS ATP (EC50 = 1 mumol/liter), added intraluminally, caused maximal vasodilation of 80 to 100% of the preconstriction response in both species. This effect was inhibited by the P1-purinoceptor antagonist 8-p-(sulphophenyl)theophylline (100 mumol/liter), suggesting that it was in part due to breakdown of ATP to adenosine. The nature of purinoceptor mediated renal vasodilation was studied further in rabbit renal arteries. Adenosine (EC50 = 1 mumol/liter) as well as the P2Y-receptor agonists ADP beta S (EC50 = 0.4 mumol/liter) and 2-MeSATP (EC50 = 0.2 mumol/liter) dilated the arteries by 80 to 100%. The effects of 2-MeSATP, which were to a much lesser extent that of ADP beta S but not that of adenosine, were attenuated by the P2Y-antagonist reactive blue 2 (3 mumol/liter). Removal of the endothelium almost abolished the vasodilation induced by adenosine and ATP. In contrast, these dilator response were only slightly attenuated by the nitric oxide synthase blockers NG-nitro-L-arginine methyl ester and NG-nitro-L-arginine (300 mumol/liter each), whereas acetylcholine and 2-MeSATP induced dilation was markedly reduced by NG-nitro-L-arginine methyl ester. CONCLUSIONS P1-purinoceptors activated by adenosine dilate rabbit renal arteries by an endothelium-derived relaxing factor that appears to be distinct from nitric oxide. In contrast, P2Y-purinoceptor induced renal dilation is mediated by nitric oxide. ATP, the physiological activator of P2Y-purinoceptors, is rapidly broken down to adenosine in rabbit and human renal arteries. Therefore, in rabbit and human renal arteries the vasodilatory effect of exogenous ATP mainly results from P1-purinoceptor activation probably through its breakdown product, adenosine.
Effect of Dietary Sunflower Seed Oil on the Severity of Reperfusion‐Induced Arrhythmias in Anesthetized Rats

Myocardial ischemia followed by reperfusion was produced in artificially respirated, open-chest rats. Coronary artery ligation for 6 min rarely evoked arrhythmias; however, reperfusion after this period rapidly produced severe dysrhythmias in all control animals. Reperfusion after 12 min of ischemia produced less frequent dysrhythmias than after coronary occlusion for 6 min. Feeding of a linoleic acid-rich diet, applying 12% sunflower seed oil in rat food pellet for 4 weeks, decreased the incidence of reperfusion-induced ventricular fibrillation both after 6 min (2/15 vs. 7/11) and 12 min (0/11 vs. 2/8) of myocardial ischemia and the incidence of other arrhythmias was also decreased. The number of animals developing no arrhythmias during reperfusion was increased (8/15 after 6 min of ischemia, 4/11 after 12 min of ischemia vs. 0/11 and 0/8 in controls, respectively). Our results indicate that increased dietary consumption of linoleic acid decreased the occurrence of life-threatening arrhythmias both during the acute phase of myocardial ischemia and during reperfusion in anesthetized rats.
The Potential Role of Exposure to Environmental Toxicants in the Pathophysiology of Endometriosis

Abstract: Humans and animals are exposed daily to a complex mixture of polyhalogenated aromatic hydrocarbons (PHAHs). Previous work has shown that exposure to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) is associated with a dose‐dependent increase in the incidence and severity of endometriosis in the rhesus monkey. Dioxin‐like chemicals can also exert effects in combination with TCDD via the aryl hydrocarbon receptor. Using a rhesus model of chronic TCDD exposure and endometriosis, serum concentrations of TCDD and 19 dioxin‐like PHAHs were quantified 13 years after termination of exposure to TCDD. In additional studies, the immune status of TCDD‐exposed monkeys was evaluated. For TCDD‐exposed and unexposed animals, TCDD exposure correlated with an increased serum TCDD concentration. Furthermore, TCDD exposure and an elevated serum TCDD concentration were associated with increased serum levels of triglycerides, 1,2,3,6,7,8‐hexachlorodibenzofuran (HxCDF), PCB77, and PCB126. Importantly, the animals with elevated serum levels of PCB77 and PCB126 and increased total serum TCDD equivalents (TEQs) had a high prevalence of endometriosis, and the severity of disease correlated with the serum concentration of PCB77. In immune studies, TCDD exposure correlated with increased tumor necrosis factor alpha (TNFα) production by peripheral blood mononuclear cells (PBMC) in response to stimulation by T cell mitogen and decreased NK cytolytic activity. Elevated serum concentrations of TCDD, 1,2,3,6,7,8‐HxCDF, and PCB126 correlated with increased numbers of CD3+/CD25− and CD3−/CD25+ leukocytes and enhanced secretion of TNFα by mitogen‐stimulated PBMC. This evidence suggests that TCDD exposure and endometriosis in the rhesus monkey may be associated with increased serum concentrations of specific coplanar PCB compounds and long‐term alterations in systemic immunity. Furthermore, the data suggest a potential involvement of an increased body burden of PCB compounds in the etiology of endometriosis in the rhesus. Recent advances in the detection and assay of individual PHAH congeners in biological samples have made it possible to assess total PHAH body burden in humans and animals. Future studies are expected to exploit this advance to assess the health impact of PHAH body burdens in both exposed individuals and the general population. Serum PHAH concentrations and TEQs in TCDD‐exposed monkeys with endometriosis are similar to or lower than blood levels in the general human population; thus, it is important to consider the implications of these findings for human health and the prevalence of endometriosis in humans. Additional studies are warranted, particularly in human subjects, to explore the potential implications of these data.
Osteopontin deficiency delays inflammatory infiltration and the onset of muscle regeneration in a mouse model of muscle injury

SUMMARY Osteopontin is secreted by skeletal muscle myoblasts and stimulates their proliferation. Expression of osteopontin in skeletal muscle is upregulated in pathological conditions including Duchenne muscular dystrophy, and recent evidence suggests that osteopontin might influence the course of this disease. The current study was undertaken to determine whether osteopontin regulates skeletal muscle regeneration. A whole muscle autografting model of regeneration in osteopontin-null and wild-type mice was used. Osteopontin expression was found to be strongly upregulated in wild-type grafts during the initial degeneration and subsequent early regeneration phases that are observed in this model. Grafted muscle from osteopontin-null mice degenerated more slowly than that of wild-type mice, as determined by histological assessment, fibre diameter and fibre number. The delayed degeneration in osteopontin-null grafts was associated with a delay in neutrophil and macrophage infiltration. Centrally nucleated (regenerating) muscle fibres also appeared more slowly in osteopontin-null grafts than in wild-type grafts. These results demonstrate that osteopontin plays a non-redundant role in muscle remodelling following injury.