Miracle-dz/UniFAR-FTUs huggingface dataset:
We Need to Discuss the Relationship - An Analysis of Facilitators and Barriers of Software Ecosystem Partnerships

Software ecosystems are a promising paradigm to develop and market software systems by means of partnerships among companies. To ensure the healthy evolution of software ecosystems, companies must define strategies that strength their partnerships. In this paper, we investigate the factors that drive the evolution of software ecosystems formed by Small-to-Medium Enterprises. We present an exploratory case study of two emergent software ecosystems in order to analyse the main facilitators and barriers faced by participating companies. We adopt System Dynamics approach to create models expressing causal relations among these factors. By understanding the facilitators that should be reinforced and barriers that should be restrained, we believe that partners are better equipped to catalyse the success of their software ecosystems.
Widespread Antisense Transcription in Escherichia coli

ABSTRACT The vast majority of annotated transcripts in bacteria are mRNAs. Here we identify ~1,000 antisense transcripts in the model bacterium Escherichia coli. We propose that these transcripts are generated by promiscuous transcription initiation within genes and that many of them regulate expression of the overlapping gene. IMPORTANCE The vast majority of known genes in bacteria are protein coding, and there are very few known antisense transcripts within these genes, i.e., RNAs that are encoded opposite the gene. Here we demonstrate the existence of ~1,000 antisense RNAs in the model bacterium Escherichia coli. Given the high potential for these RNAs to base pair with mRNA of the overlapping gene and the likelihood of clashes between transcription complexes of antisense and sense transcripts, we propose that antisense RNAs represent an important but overlooked class of regulatory molecule. The vast majority of known genes in bacteria are protein coding, and there are very few known antisense transcripts within these genes, i.e., RNAs that are encoded opposite the gene. Here we demonstrate the existence of ~1,000 antisense RNAs in the model bacterium Escherichia coli. Given the high potential for these RNAs to base pair with mRNA of the overlapping gene and the likelihood of clashes between transcription complexes of antisense and sense transcripts, we propose that antisense RNAs represent an important but overlooked class of regulatory molecule.
Weak compactness in the dual space of a JB*-triple is commutatively determined

We prove the following criterium of weak compactness in the dual of a JB*-triple: a bounded set $K$ in the dual of a JB*-triple $E$ is not relatively weakly compact if and only if there exist a sequence of pairwise orthogonal elements $(a_n)$ in the closed unit ball of $E$, a sequence $(\varphi_{n} )$ in $K$, and $\vartheta >0$ satisfying that $|\varphi_{n}(a_{n})|>\vartheta$ for all $n \in {\mathsf N}$. This solves a question stimulated by the main result in [11] and posed in [9].
Design, Analysis, and Simulation of I/O Architectures for Hypercube

Several issues concerning the design of an I/O (input/output) system for a multiprocessor such as a hypercube are examined. A methodology is proposed for connecting the I/O processors to such a system for efficient I/O access. The effect of I/O communication on the multiprocessor network is analyzed. Different disk organizations that can be employed within such a system are evaluated to see which organization has a better performance. It is observed that parallelism in serving an I/O request plays a dominant role in the scientific workload. The problem of mapping specific data structures such as matrices onto the disks so that the data can be accessed efficiently is considered. >
ZBTB7 Overexpression Contributes to Malignancy in Breast Cancer

ABSTRACT ZBTB7 was recently recognized as a proto-oncogene. We studied its prognostic value and relationship to clinicopathological variables in 125 breast cancer patients. ZBTB7 expression was significantly higher in breast cancer tissues than in normal breast tissues, but its gene amplification copies were relatively low. ZBTB7 expression levels were significantly correlated with histological grade (p = .023) and marginally inversely correlated with the presence of estrogen receptors (p = .053); its overexpression significantly predicted shorter recurrence-free survival (p = .033). Our results showed that ZBTB7 might be implicated in breast cancer development and may serve as a promising prognostic marker.
New treatment of acute hypoxemic respiratory failure: noninvasive pressure support ventilation delivered by helmet--a pilot controlled trial.

OBJECTIVE To assess the efficacy of noninvasive pressure support ventilation (NPSV) using a new special helmet as first-line intervention to treat patients with hypoxemic acute respiratory failure (ARF), in comparison to NPSV using standard facial mask. DESIGN AND SETTING Prospective clinical pilot investigation with matched control group in three intensive care units of university hospitals. PATIENTS AND METHODS Thirty-three consecutive patients without chronic obstructive pulmonary disease and with hypoxemic ARF (defined as severe dyspnea at rest, respiratory rate >30 breaths/min, PaO2:FiO2 < 200, and active contraction of the accessory muscles of respiration) were enrolled. Each patient treated with NPSV by helmet was matched with two controls with ARF treated with NPSV via a facial mask, selected by simplified acute physiologic score II, age, PaO2/FiO2, and arterial pH at admission. Primary end points were the improvement of gas exchanges, the need for endotracheal intubation, and the complications related to NPSV. RESULTS The 33 patients and the 66 controls had similar characteristics at baseline. Both groups improved oxygenation after NPSV. Eight patients (24%) in the helmet group and 21 patients (32%) in the facial mask group (p = .3) failed NPSV and were intubated. No patients failed NPSV because of intolerance of the technique in the helmet group in comparison with 8 patients (38%) in the mask group (p = .047). Complications related to the technique (skin necrosis, gastric distension, and eye irritation) were fewer in the helmet group compared with the mask group (no patients vs. 14 patients (21%), p = . 002). The helmet allowed the continuous application of NPSV for a longer period of time (p = .05). Length of stay in the intensive care unit, intensive care, and hospital mortality were not different. CONCLUSIONS NPSV by helmet successfully treated hypoxemic ARF, with better tolerance and fewer complications than facial mask NPSV.
Multiple Broad-Spectrum Beta-Lactamase Targets for Comprehensive Surveillance

ABSTRACT Real-time PCR testing for bla KPC, bla NDM, bla VIM, bla IMP, and bla CTX-M was performed on rectal swabs obtained from residents of two long-term acute-care facilities. While bla KPC was detected in 69/102 swabs (67.6%), testing for four other targets increased the positivity rate for a broad-spectrum β-lactamase to 73.5% (McNemar's P = 0.03).
N-Shc and Sck, Two Neuronally Expressed Shc Adapter Homologs

The Shc adapter protein is ubiquitously expressed and has been implicated in phosphotyrosine signalings following a variety of extracellular stimulation, e.g. growth factor stimulation, Ca2+ elevation, and G-protein-coupled receptor stimulation. In neuronal cells such as PC12, Shc was demonstrated to be involved in vitro in Ras-dependent mitogen-activated protein kinase activation following nerve growth factor stimulation and Ca2+ entry. However, Shc mRNA was hardly detectable in the brain, and therefore, Shc is unlikely to participate in phosphotyrosine signaling in the central nervous system. Two recently isolated Shc homologs, N-Shc and Sck, have been shown to be expressed in the brain and are expected to function as neuronal adapters instead of Shc. In this study, the neuronal distribution and function of these novel Shc members were investigated. In human and rat central nervous systems, the expression profiles of N-Shc and Sck mRNAs considerably overlapped, although some distinct localization between them was observed: in the adult rat brain, the level of N-Shc mRNA was the highest in the thalamus, whereas that of Sck mRNA was the highest in the hippocampus. In the peripheral nervous system, transcripts of Shc and Sck, but not of N-Shc, were detected. Immunoprecipitation experiments demonstrated functional differences between N-Shc and Sck: (i) N-Shc was a higher affinity adapter molecule than Sck in nerve growth factor and brain-derived neurotrophic factor signaling; and (ii) N-Shc, but not Sck, was efficiently phosphorylated by activated Src tyrosine kinase, whereas Sck, but not N-Shc, formed a complex with pp135, a protein highly phosphorylated by v-Src. These results suggest that neurally expressed N-Shc and Sck may have distinct roles in neuronal signaling in the brain.
Improved reproducibility of reverse‐phase protein microarrays using array microenvironment normalization

We introduce a novel experimental methodology for the reverse‐phase protein microarray platform which reduces the typical measurement CV as much as 70%. The methodology, referred to as array microenvironment normalization, increases the statistical power of the platform. In the experiment, it enabled the detection of a 1.1‐fold shift in prostate specific antigen concentration using approximately six technical replicates rather than the 37 replicates previously required. The improved reproducibility and statistical power should facilitate clinical implementation of the platform.
Effective Connectivity of Depth-Structure–Selective Patches in the Lateral Bank of the Macaque Intraparietal Sulcus

Extrastriate cortical areas are frequently composed of subpopulations of neurons encoding specific features or stimuli, such as color, disparity, or faces, and patches of neurons encoding similar stimulus properties are typically embedded in interconnected networks, such as the attention or face-processing network. The goal of the current study was to examine the effective connectivity of subsectors of neurons in the same cortical area with highly similar neuronal response properties. We first recorded single- and multi-unit activity to identify two neuronal patches in the anterior part of the macaque intraparietal sulcus (IPS) showing the same depth structure selectivity and then employed electrical microstimulation during functional magnetic resonance imaging in these patches to determine the effective connectivity of these patches. The two IPS subsectors we identified—with the same neuronal response properties and in some cases separated by only 3 mm—were effectively connected to remarkably distinct cortical networks in both dorsal and ventral stream in three macaques. Conversely, the differences in effective connectivity could account for the known visual-to-motor gradient within the anterior IPS. These results clarify the role of the anterior IPS as a pivotal brain region where dorsal and ventral visual stream interact during object analysis. Thus, in addition to the anatomical connectivity of cortical areas and the properties of individual neurons in these areas, the effective connectivity provides novel key insights into the widespread functional networks that support behavior.
Multiple Ets Factors and Interferon Regulatory Factor-4 Modulate CD68 Expression in a Cell Type-specific Manner*

CD68 is a transmembrane glycoprotein expressed in all cells of the mononuclear phagocyte lineage including monocytes and tissue resident macrophages. Deletion analysis of the 5′-flanking sequences of the gene demonstrated that the proximal –150-bp sequence of the CD68 promoter exhibits high level promoter activity in macrophages. Mutations that abolish Ets factor binding at positions –106 and –89 reduce promoter activity in macrophages to 12 and 30%, respectively. Band shift experiments show that PU.1 associates with the –89 site whereas, Elf-1 preferentially binds the –106 Ets binding site and enhances CD68 activity in vitro. Furthermore, chromatin immunoprecipitation experiments confirm that Elf-1 and PU.1 associate with the CD68 proximal promoter in vivo in THP-1 cells. PU.1 does not bind to the CD68 promoter alone but instead forms heterocomplexes with members of the interferon regulatory factor family (IRF) including IRF-4 and IRF-8. IRF-4 and IRF-8 typically mediate transcriptional activation when associated with PU.1 on composite elements. However, our data show that PU.1/IRF-4 and IRF-8 heterocomplexes down-regulate CD68 promoter activity in macrophages and repression is dependent on the integrity of both the IRF and PU.1 half-sites of this composite element. Chromatin immunoprecipitation data reveal that neither IRF-4 nor IRF-8 associate with the CD68 proximal promoter in macrophages in vivo but IRF-4 is associated with the promoter in B lymphocytes. We propose that expression of CD68 in myeloid cells requires the Ets transcription factors Elf-1 and PU.1 and CD68 expression is down-regulated in lymphoid cells by combinatorial interactions between PU.1 and IRF-4.
Wearable Modular Telemetry System for the Integrated Rescue System Operational Use

The article summarizes the development of the FlexiGuard modular telemetry system designed for enhancing safety of the Integrated Rescue System team members in solving crisis situations and for improving training processes. Further framework solutions, which lead to the development of automatic modular telemetry system allowing for real time monitoring of physiological parameters, are provided as well. The system provides for the signalization of critical states such as exhaustion, mental stress, and overheating. It further provides differentiation between the nature and intensity of movement, including actual and overall energy output, monitoring environmental parameters, and analysis of an intervention or training. The system has been tested in laboratories as well as in the terrain under real circumstances, and the eventual end users participated in its optimization process. Following the theory of games, a model of a transmission system was also created which demonstrates higher transmission efficiency when using higher number of nodes.
Statistical channel modelling and performance evaluation in satellite personal communications

This paper is concerned with channel modelling for satellite personal communications and with the associated problem of performance evaluation. Channel characteristics for personal communications tend to differ from those traditionally accepted for vehicular communications. In this paper we report on modelling aspects for both wideband and narrowband personal communications. Then we consider performance evaluation for low-altitude earth orbit (LEO) satellite systems in terms of bit error probability and outage probability. To evaluate the outage probability for LEO systems, a tight and simple upper bound is finally provided. (C) 1998 John Wiley & Sons, Ltd.
Wind farm layout design using modified particle swarm optimization algorithm

Wind energy has shown tremendous potential for power generation. The energy is generated by wind turbines placed in a wind farm. To extract maximum energy from these wind farms, one of the most important issues is an efficient layout of the farms. This layout governs the location of each turbine in the wind farm. Due to its complexity, the wind farm layout design problem is classified as a complex optimization problem. Several attempts have been made previously to come up with better approaches and algorithms for optimization of wind farm. This paper proposes yet another optimization algorithm which is based on the particle swarm optimization (PSO) algorithm, which is a popular optimization algorithm. The proposed algorithm, termed as the modified particle swarm optimization algorithm (MPSO), is compared with previous results generated by another optimization algorithm, namely, genetic algorithm. Results indicate that MPSO generated better results.
A low-power radio chipset in 40nm LP CMOS with beamforming for 60GHz high-data-rate wireless communication

The link budget of multi-Gb/s wireless communication systems around 60GHz improves by beamforming. CMOS realizations for this type of communication are mostly limited to either one-antenna systems [1], or beamforming ICs that do not implement all radio functions [2]. The sliding-IF architecture of [3] uses RF phase shifting, which deteriorates noise performance.
De Subventione Pauperum sive De Humanis Necessitatibus, libri II

Acknowledgements Introduction I. Prefatroy Remarks II. Circumstances of Composition III. Summary IV. Historical Background V. Editions and Constitution of the Text VI. Translations VII. Abbreviations used in the Introduction, Apparatus and Notes Sigla De Subventione Pauperum sive De humanis necessitatibus Praefatio: Iohannes Lodovicus Vives Consulibus et Senatui Brugensi Salutem Book I. De subventione privata quid unumquemque facere oporteat Book II. De subventione publica quid civitatem deceat Appendix: Annotatiunculae fratris Ioannis Moyardi Index Nominum Index Locorum
Aerodynamic sectional modeling with the use of extended vectors

This paper presents the dynamic model of an Unmanned Aerial Vehicle (UAV), specifically, a fixed-wing aircraft PT-40, using extended vectors in ℝ6. This representation of cartesian coordinates in the Euclidian space simplifies the representation of the model to express each term in a single six dimensional vectorial equation, instead of the three dimensional, conventional linear and angular movement equations. The algebra to manipulate these elements reduces the number of operations and defines the basic transformations between the reference frames. The UAV is a free rigid body in ℝ3 subject to aerodynamic forces, which are included in the model as exogenous forces. Typically these forces are calculated using dimensionless coefficients that capture the geometric complexity of the aircraft in the Aerodynamic Center of Pressure, resulting in a model with lumped aerodynamic parameters. Due to the advantages of the extended vectors, the aerodynamic forces acting on each component of the aircraft can be included in the mathematical model as independent effects.
Lethal effects of synthetic juvenile hormone on the human body louse.

Synthetic juvenile hormone (SJH) was prepared as described by Law et al.2 by bubbling hydrogen chloride gas through an ice-cold solution of farnesenic acid (Frinton Laboratories, South Vineland, New Jersey) dissolved in 100 volumes of absolute ethanol. The flow of gas was continued for five minutes to give a 9.4 per cent increase in weight. The flask was stoppered and stored in an ice bath in the dark for four hours. It was then warmed to room temperature and stored in the dark for an additional 19 hours. The reaction mixture was rinsed with petroleum ether into a separatory funnel and washed three times with an excess of water. The ethereal phase was collected and the solvent removed on a rotary evaporator at room temperature. The resultant golden oil was rinsed with 95 per cent ethanol into a separatory funnel and water added to incipient cloudiness. The solution was neutralized with 0.1 M sodium hydroxide to a phenolphthalein end-point and the ethereal phase collected and reduced to dryness on a rotary evaporator. The resultant golden oil, which was used without any further purification, is known to contain six materials with high juvenile hormone activity. For convenience of expression in the present report, this mixture of materials is called "synthetic juvenile hormone. " Exposure of lice and lice eggs to SJH: Adult lice were placed on 3- X 3-cm woolen pads impregnated with known concentrations of SJH and eggs were deposited on the pads. In control experiments lice were- placed and eggs were laid on pads impregnated with a corresponding amount of peanut oil. Each pad was impregnated with 1 ml of a solution of SJH or peanut oil in absolute methanol; the solvent was evaporated before use. The number of eggs on each pad was counted with the aid of a dissecting microscope. Empty or collapsed eggs were discarded. To facilitate counting, a piece of glass marked into a grid with a diamond pencil was placed over the pad. The grid was rinsed in acetone and in 95 per cent ethanol to prevent contamination of subsequent pads. Experimental and control lice were fed in separate compartments of an arena on the shaved belly of a rabbit. The shaved skin was washed with 70 per cent ethanol before and after feeding and the arena with acetone after each use.
Strain rate imaging combined with wall motion analysis gives incremental value in direct quantification of myocardial infarct size.

BACKGROUND The study aimed to evaluate the diagnostic accuracy of a new method for direct echocardiographic quantification of the myocardial infarct size, using late enhancement magnetic resonance imaging (LE-MRI) as a reference method. METHODS AND RESULTS Echocardiography and LE-MRI were performed on average 31 days after first-time myocardial infarction in 58 patients. Echocardiography was also performed on 35 healthy controls. Direct echocardiographic quantification of the infarct size was based on automated selection and quantification of areas with hypokinesia and akinesia from colour-coded strain rate data, with manual correction based on visual wall motion analysis. The left ventricular (LV) ejection fraction, speckle-tracking-based longitudinal global strain, wall motion score index (WMSI), longitudinal systolic motion and velocity, and the ratio of early mitral inflow velocity to mitral annular early diastolic velocity were also measured by echocardiography. The area under the receiver-operating characteristic curves for the identification of the infarct size >12% by LE-MRI was 0.84, using the new method for direct echocardiographic quantification of the infarct size. The new method showed significantly a higher correlation with the infarct size by LE-MRI both at the global (r = 0.81) and segmental (r = 0.59) level compared with other indices of LV function. CONCLUSION Direct quantification of the percentage infarct size by strain rate imaging combined with wall motion analysis yields high diagnostic accuracy and better correlation to LE-MRI compared with other echocardiographic indices of global LV function. Echocardiography performed ~1 month after myocardial infarction showed ability to identify the patients with the infarct size >12%.
Collaborative Map Making: A Reflexive Method for Understanding Matters of Concern in Design Research

HCI researchers investigating the politics of technology design have recently focused on how design practice can tackle "Matters of Concern" - complex social issues perceived and experienced in multiple ways. These researchers suggest design research can generate new networks of human and non-human actors to express and act on these issues. Prior studies, however, tend to restrict their networks within traditional boundaries (e.g. existing organizations, local communities) and categories (e.g. human/nonhuman binary) without examining their significance for participants. We suggest collaborative map making as a reflexive method for understanding current Matters of Concern from the perspectives of diverse actors, not just researchers. As case studies of the method's use, we present two studies of domestic computing technologies in the US and South Korea, which show how collaborative map making allows salient networks to expand beyond the individual actors in the home to local and global power issues outside of boundaries (e.g. physical house) and categories (e.g. private/public space) commonly recognized in HCI. Our methodology provides HCI researchers with a way to understand existing Matters of Concern, so they can position themselves to address and act on these issues.