Miracle-dz/UniFAR-FTUs huggingface dataset:
Osteoporosis Knowledge Among Individuals With Recent Fragility Fracture

BACKGROUND To evaluate osteoporosis knowledge among patients with fractures and to evaluate factors associated with osteoporosis knowledge. METHODS Patients with fragility fractures participated in a telephone interview. Participants were asked what they thought osteoporosis was. Unadjusted odds ratios (OR, 95% CI) were calculated to identify factors associated with a correct definition. Predictors identified in univariate analysis were entered into multivariable logistic regression models. A subset also completed the Facts on Osteoporosis Quiz. RESULTS One hundred twenty-seven patients (82% women) participated in the study, with mean (SD) age being 67.5 (12.7) years. Ninety-five (75%) respondents gave correct osteoporosis definitions. The odds of an individual providing a correct definition of osteoporosis were higher for those who reported a diagnosis of osteoporosis or those who reported higher education levels, but the odds decreased with increasing age. A total of 49 (39%) respondents completed the Facts on Osteoporosis Quiz; the average score was 13.6 (3.8) of 21. Areas that respondents scored poorly on were related to key risk factors. CONCLUSION Many patients with fractures are unaware of important risk factors. Education initiatives aimed at improving osteoporosis knowledge should be directed at individuals at high risk of fracture. Nurses and other allied healthcare providers working in fracture clinics, acute care, and rehabilitation settings are in an ideal position to communicate information about osteoporosis and fracture risk to individuals with a recent fragility fracture.
Assisted leg displacements and progressive loading by a tilt table combined with FES promote gait recovery in acute stroke.

OBJECTIVE Here we developed and tested a novel system for early motor rehabilitation in acute stroke when patients are unable to stand and walk without assistance. Stepping performance may be largely facilitated by providing treatment in the supine position on a tilt table using step-synchronized functional electrical stimulation (FES) with assisted leg movements and progressive limb loading. METHODS Sixty-one individuals with acute stroke were randomly assigned to two groups, experimental and control. The first group received both a conventional therapy and FES-therapy combined with progressive limb loading, whereas the control group received a conventional therapy only. Changes after treatment were assessed using clinical scores and neurophysiological measurements of movement performance. RESULTS After treatment, there was an improvement of the clinical scores, muscle forces and everyday life activity performance in both groups, however, significantly higher in the experimental group. Active rhythmic movements of the non paretic leg often provoked muscle activity in the paretic leg as well as there was a reduction of the contralateral leg muscle contraction during paretic leg movements. CONCLUSION The developed FES and leg displacement-assisted therapy facilitates a smooth transition to walking in the vertical position and increases the patient's functional abilities and the effectiveness of rehabilitation.
Effect of Spiritual Leadership to Organizational Culture and Employee’s Loyalty

Although the leader of the Society’s Eye Hospital, East Java has the characteristics of spiritual leadership as in the dimensions of spiritual leadership developed by Fry (2003) including vision, hope / faith, and altruistic love, however the level of employee turn over is still high. To address this problem, the research is using a quantitative causality approach and SEM PLS model as the data analysis technique used. The result of the research shows that there is a significant positive influence on spiritual leadership towards the organizational culture. A significant positive influence of organizational culture also seen on employee’s loyalty, and there is a positive but insignificant influence of spiritual leadership on employee’s loyalty.
Cardioprotective and Survival Benefits of Long-Term Combined Therapy with β2 Adrenoreceptor (AR) Agonist and β1 AR Blocker in Dilated Cardiomyopathy Postmyocardial Infarction

We have reported therapeutic effectiveness of pharmacological stimulation of β2 adrenoreceptors (ARs) to attenuate the cardiac remodeling and myocardial infarction (MI) expansion in a rat model of dilated cardiomyopathy (DCM) post-MI. Furthermore, the combination of β2 AR stimulation with β1 AR blockade exceeded the therapeutic effectiveness of β1 AR blockade. However, these studies were relatively short (6 weeks). In this study, in the same experimental model, we compared different effects, including survival benefit, of combined therapy with the β1 AR blocker, metoprolol, plus the β2 AR agonist, fenoterol (β1–β2+), and either therapy alone (β1– or β2+) during the 1-year study. Therapy was started 2 weeks after permanent ligation of the left coronary artery. Cardiac remodeling, MI expansion, and left ventricular function were assessed by serial echocardiography and compared with untreated animals (nT). Sixty-seven percent mortality in nT was reduced to 33% in the β1–β2+ (p < 0.01). Progressive cardiac remodeling observed in nT and β1– was significantly attenuated in β1–β2+ during the first 6 months of treatment. In β1–β2+, MI expansion was completely prevented, and functional decline was significantly attenuated during the entire year. Myocardial apoptosis was significantly reduced in both β1–β2+ and β1–. A reduction of cardiac β1 AR density and decreases in chronotropic and contractile responses to β2 AR-specific stimulation in the absence of a reduction of β2 AR density in nT were precluded in rats receiving combined therapy. The results demonstrate the cardioprotective and survival benefit of long-term combination therapy of β2 AR agonists and β1 AR blockers in a model of DCM.
Building a tourist destination brand from the relational perspective: the Italian project “South Destination Network”

The paper deals with a case study regarding an Italian tourism project analysed through the lens of a multiple perspectives framework based on the Relational View (RV), Stakeholder Engagement (SE), and Value Cocreation (VCc). The proposed theoretical framework contributes to interpreting issues regarding the development of a tourist destination brand in Southern Italy. The qualitative approach adopted reflects the confirmatory nature of this paper. Meanwhile, the project denominated “South Destination Network” is an experimental building of a tourism destination brand from the relational view of maximizing value co-creation in a cultural perspective though stakeholder engagement. Findings from the case study are discussed with reference to the relational view, stakeholder engagement, and value co-creation. The study concludes with the limitations and implications for further research related to the proposed framework.
The impact of Foreign Direct Investments on employment: the case of the Macedonian manufacturing sector

As a less developed post-transition country, Macedonia has marked a moderate growing economic performance coupled with high and sustained unemployment during the past decade. In this context, fostering FDI has been promoted by the Macedonian government as one of the main instruments for generating employment and providing further economic development. The aim of this paper is to assess the impact of FDI on employment in Macedonian manufacturing sectors, which has been assessed by applying a single equation error correction model. The results indicate that FDI and personnel costs are statistically significant factors that positively affect employment in the manufacturing sub-sectors which, due to their interaction, might indicate higher productivity in the companies with FDI. In addition, the negative impact of the relative personnel cost per employee vis-a-vis Serbia in the short-run reaffirms the assertion that FDI in the Macedonian manufacturing sectors is mainly driven by efficiency seeking motives.
Randomized Trial of Oral Versus Sequential IV/Oral Antibiotic for Acute Pyelonephritis in Children

OBJECTIVE: To confirm whether oral antibiotic treatment is as efficacious as sequential intravenous/oral antibiotic treatment in the prevention of renal scarring in children with acute pyelonephritis and scintigraphy-documented acute lesions. METHODS: In a prospective multicenter trial, children aged 1 to 36 months with their first case of acute pyelonephritis, a serum procalcitonin concentration ≥0.5 ng/mL, no known uropathy, and a normal ultrasound exam were randomized into 2 treatment groups. They received either oral cefixime for 10 days or intravenous ceftriaxone for 4 days followed by oral cefixime for 6 days. Patients with acute renal lesions detected on early dimercaptosuccinic acid scintigraphy underwent a follow-up scintigraphy 6 to 8 months later. RESULTS: The study included 171 infants and children. There were no significant differences between the 2 groups in any clinical characteristic. Initial scintigraphy results were abnormal for 119 children. Ninety-six children were measured for renal scarring at the follow-up scintigraphy (per protocol analysis population). The incidence of renal scarring was 30.8% in the oral treatment group and 27.3% for children who received the sequential treatment. CONCLUSIONS: Although this trial does not statistically demonstrate the noninferiority of oral treatment compared with the sequential treatment, our study confirmed the results of previously published reports and therefore supports the use of an oral antibiotic treatment of primary episodes of acute pyelonephritis in infants and young children.
Rapid FDI Expansion of Firms from Emerging Markets: Evidence from Poland

The conventional theory of gradual internationalization goes against the global trend of rapid foreign expansion as applied in particular to emerging markets. In this study we examine the conditions of rapid foreign direct investment (FDI) expansion that can be beneficial to firm performance. In order to do so we examine a firm’s internal factors, such as firm specific advantages (FSAs) and strategy, as well as external factors including domestic and foreign influences that moderate the relationship between firm performance and the speed of FDI expansion. By conducting empirical tests on data on Polish firms’ expansion, we find that some FSAs (profit per employee and foreign sales), as well as some aspects relevant to strategy (geographic and cultural distances), negatively influence the relationship between speed of FDI expansion and firm performance. From our results we conclude that Polish companies are unique in the way that neither gradual internationalization nor rapid foreign expansion amounts to a suitable strategy for them. The Polish market, exhibiting a combination of transition and emerging economy characteristics, must apply its own distinctive FDI strategy to compete in foreign markets.
Snobbish Bandwagoners: Ambiguity of Luxury Goods’ Perception

Abstract Purpose: The article explores the grounds of possible interrelations of snob and bandwagon consumers’ inclinations in the luxury fashion sector. The reason to investigate this comes from the growth of inconsistent evidence among analyses of this subject. Consumers’ perception of luxury goods seems not only compound but also quite ambiguous at the same time. One of its reasons may be the wrong assumption that snob and bandwagon inclinations are opposite trends that cannot co-exist among individual motives of luxury purchases. Methodology and findings: The mixed method research – in the form of international consumers’ e-survey and semi-structured interviews with affluent consumers – reveals that mutual relations of these two trends are clearly visible and can both motivate purchase at the same time.
Saving Space by Dynamic Algebraization Based on Tree Decomposition: Minimum Dominating Set

An algorithm is presented that solves the Minimum Dominating Set problem exactly using polynomial space based on dynamic programming for a tree decomposition. A direct application of dynamic programming based on a tree decomposition would result in an exponential space algorithm, but we use zeta transforms to obtain a polynomial space algorithm in exchange for a moderate increase of the time. This framework was pioneered by Lokshtanov and Nederlof 2010 and adapted to a dynamic setting by F\"urer and Yu 2017. Our space-efficient algorithm is a parametrized algorithm based on tree-depth and treewidth. The naive algorithm for Minimum Dominating Set runs in $\mathcal{O}^*(2^n)$ time. Most of the previous works have focused on time complexity. But space optimization is a crucial aspect of algorithm design, since in several scenarios space is a more valuable resource than time. Our parametrized algorithm runs in $\mathcal{O}^*(3^{d})$, and its space complexity is $\mathcal{O}(nk)$, where $d$ is the depth and $k$ is the width of the given tree decomposition. We observe that Reed's 1992 algorithm constructing a tree decomposition of a graph uses only polynomial space. So, even if the tree decomposition is not given, we still obtain an efficient polynomial space algorithm. There are some other algorithms which use polynomial space for this problem, but they are not efficient for graphs with small tree depth.
Four‐dimensional temperature distributions in red blood cells withdrawn from storage and exposed to ambient temperature: a magnetic resonance thermometry study

BACKGROUND: Recommended by current guidelines, red blood cell (RBC) temperature should not exceed 10°C during transport. Since warming is a generically three‐dimensional process that is not homogeneous, it is necessary to clarify the term “temperature during warming. ” The purpose of this study was therefore to investigate laws and relations between surface, mean, and core temperature and the corresponding times when they exceed 10°C during warm‐up.
Aggregation of human platelets by gingipain-R from Porphyromonas gingivalis cells and membrane vesicles

The hypothesis that there is an association between periodontitis and cardiovascular disease suggests new lines of research on the mechanism whereby oral bacteria might exert systemic effects. This study was conducted to ascertain and quantitate the effect of Porphyromonas gingivalis on human platelets in vitro . A second related objective was to purify and identify the aggregating vector. Aggregation was measured by platelet turbidometry and gingipain-R was purified from P. gingivalis membrane vesicles by Sepharose 2B and hydroxyapatite chromatography. The in vitro aggregation of platelets requires that at least 1.0 2 10 4 cells be stirred with 1.35 2 10 8 platelets. The specific activity is substantially increased in the membrane vesicles that are shed by this bacterium. Aggregability was due to gingipain-R activity, a potent cysteine protease that was found to be highly concentrated in the membrane vesicle fraction. The enzyme was purified 18-fold in high yield from the membrane vesicles, and consists of two noncovalently linked proteins that migrate at 49 and 44 kDa on SDS-PAGE. Aggregation of platelets by gingipain-R was shown to be dose-dependent, and inhibited by leupeptin and arginine, but not by anti-thrombin III. This is the first report enumerating the specific number of cells and lowest concentration of membrane vesicles necessary to evoke a full human platelet response, and the first report to assign this activity to gingipain-R.
A Separation Principle for Control in the Age of Deep Learning

We review the problem of defining and inferring a state for a control system based on complex, high-dimensional, highly uncertain measurement streams, such as videos. Such a state, or representation, should contain all and only the information needed for control and discount nuisance variability in the data. It should also have finite complexity, ideally modulated depending on available resources. This representation is what we want to store in memory in lieu of the data, as it separates the control task from the measurement process. For the trivial case with no dynamics, a representation can be inferred by minimizing the information bottleneck Lagrangian in a function class realized by deep neural networks. The resulting representation has much higher dimension than the data (already in the millions) but is smaller in the sense of information content, retaining only what is needed for the task. This process also yields representations that are invariant to nuisance factors and have maximally independent components. We extend these ideas to the dynamic case, where the representation is the posterior density of the task variable given the measurements up to the current time, which is in general much simpler than the prediction density maintained by the classical Bayesian filter. Again, this can be finitely parameterized using a deep neural network, and some applications are already beginning to emerge. No explicit assumption of Markovianity is needed; instead, complexity trades off approximation of an optimal representation, including the degree of Markovianity.
Assessing the impact of age, race, ethnicity and inhibitor status on functional limitations of patients with severe and moderately severe haemophilia A

Summary. Few data exist on the impact of age and inhibitor status on activity levels among patients with severe and moderately severe haemophilia A. The aim of this analysis was to assess the impact of age, race/ethnicity and inhibitor status on functional limitations through retrospective analysis of data from the Hemophilia and Thrombosis Research Society (HTRS) Registry. Functional status data from patients with haemophilia A with or without inhibitors who were enrolled in the HTRS Registry between October 1999 and July 2008 were analysed by age, race and ethnicity. Of the 2497 registrants, 1340 had congenital haemophilia A (333 with inhibitors). Functional status was available for 274 subjects with haemophilia A with current inhibitors and 247 subjects without inhibitors who had moderately severe (FVIII levels ≤2%). Functional impairment increased with age across five levels of functional status (P < 0.01). Inhibitors were associated with greater functional impairment in two age groups (13–21 years and older than 21 years) [unrestricted activity in 57.8% vs. 63.6% (P = 0.06) and 18.3% vs. 28.6% (P = 0.04), respectively]. Blacks had worse functional status than caucasians across all ages regardless of inhibitor status. Functional status decreases with age, and impairment is greater among patients with inhibitors beginning in adolescence. These results reaffirm the need for early eradication of inhibitors and early treatment of bleeds in inhibitor and non‐inhibitor patients. This analysis highlights the benefit of ongoing study of these patients through data collected for the HTRS Registry.
Explaining the embodied hospitality experience with ZMET

Purpose Scholars have rarely applied an embodied perspective when studying hospitality experiences. They have given even less attention to methodological considerations. This paper aims to introduce Zaltman’s Metaphor elicitation Technique (ZMET) to explore various domains of the embodied experience. Design/methodology/approach In demonstrating the applicability of the ZMET procedure to understanding embodied hospitality experiences, the researchers present a study of emotional encounters that involve the dining experiences of Chinese tourists with Western cuisine. The focus of the paper is on data collection, i.e. detailing the step-wise procedures of ZMET that have received minimal scholarly attention. Findings Through the medium of this empirical study, the ZMET example uncovers deep metaphors and answers previously unanswered questions about embodied experiences. The detailed information and nuanced insights that are generated through this ZMET application offer the prospect of enhanced understanding of the hospitality experience. Originality/value This investigation contributes an innovative research method to the embodied experience in the hospitality and tourism context.
Sequence of the structural gene (rmpM) for the class 4 outer membrane protein of Neisseria meningitidis, homology of the protein to gonococcal protein III and Escherichia coli OmpA, and construction of meningococcal strains that lack class 4 protein

The structural gene (rmpM) of the class 4 outer membrane protein of Neisseria meningitidis has been cloned and sequenced. The derived amino acid sequence reveals a 218-amino-acid protein following a 22-amino-acid signal peptide. The protein shows 94.2% homology with protein III of Neisseria gonorrhoeae and shares its two potential disulfide loops. The protein also shares limited homology with Escherichia coli OmpA. N. gonorrhoeae protein III has been shown to elicit blocking antibodies that prevent the killing of serum-resistant strains by immune sera (P. A. Rice, H. E. Vayo, M. R. Tam, and M. S. Blake, J. Exp. Med. 164:1735-1748, 1986). The very close homology of meningococcal class 4 protein with gonococcal protein III suggests that meningococcal outer membrane preparations containing class 4 protein may similarly stimulate blocking antibodies. In order to investigate the role of the class 4 protein in the pathogenesis of meningococcal infection, we have used an erythromycin resistance gene in developing two meningococcal strains that lack class 4 protein.
Influence of Lifelong Soy Isoflavones Consumption on Bone Mass in the Rat

Soy isoflavones (IFs) have shown a bone-sparing effect through epidemiological studies in the Asian population. However, there is no evidence as to whether such protection would result from a lifelong exposure. We investigated the impact of an early exposure to IFs on bone status. Sixty female Wistar rats were fed either a standard diet (n = 30) or the same food enriched with IFs (0.87 mg/g of diet) (n = 30). After 1 month, they were allowed to mate, and were kept on the same regimen during the whole gestation and lactation periods. At weaning, female pups were each assigned to one of four nutritional groups; within each experimental group, animals were split into two groups, fed either the standard or the IF-rich diet. At 2, 3, 6, 12, 18, and 24 months after birth, 10 animals in each group were sacrificed. Femurs were collected for mechanical testing and bone mineral density (BMD) measurement. The rats perinatally or lifelong exposed to the IF-rich diet exhibited higher body weight and fat mass at 24 months of age. Peak bone mass was achieved between 6 and 12 months and did not differ between groups. In animals perinatally exposed to IF, BMD continued to increase. Thus, at 24 months, femoral total BMD (P < 0.05), metaphyseal BMD (P < 0.01), and failure load (P < 0.05) were higher in the offspring born from mothers provided IF during pregnancy. Postnatal exposure alone did not improve bone parameters. This experiment provides evidence that perinatal exposure to phytoestrogens leads to a higher BMD later in life. It is suggested that these changes may have occurred as a consequence of programming effects, as has been shown for the endocrine and immune systems.