Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantitative time-resolved chemoproteomics reveals that stable O-GlcNAc regulates box C/D snoRNP biogenesis

Significance In mammalian cells, more than 1,000 intracellular proteins are posttranslationally modified with O-linked GlcNAc (O-GlcNAc), which regulates many important biological processes. The O-GlcNAc modification has been found to dynamically cycle on and off the modified proteins. How O-GlcNAc affects protein stability remains to be investigated at the proteome level. In this work, we developed a quantitative time-resolved proteomic strategy to analyze the turnover dynamics of O-GlcNAcylated proteins. We discovered that not all protein O-GlcNAcylation events were reversible and that a subset of O-GlcNAcylated proteins exhibited minimal removal of O-GlcNAc or degradation of protein backbones. Our work reveals stable O-GlcNAc as an important regulatory mechanism for stabilizing proteins, such as core proteins of box C/D small nucleolar ribonucleoprotein complexes. O-linked GlcNAcylation (O-GlcNAcylation), a ubiquitous posttranslational modification on intracellular proteins, is dynamically regulated in cells. To analyze the turnover dynamics of O-GlcNAcylated proteins, we developed a quantitative time-resolved O-linked GlcNAc proteomics (qTOP) strategy based on metabolic pulse-chase labeling with an O-GlcNAc chemical reporter and stable isotope labeling with amino acids in cell culture (SILAC). Applying qTOP, we quantified the turnover rates of 533 O-GlcNAcylated proteins in NIH 3T3 cells and discovered that about 14% exhibited minimal removal of O-GlcNAc or degradation of protein backbones. The stability of those hyperstable O-GlcNAcylated proteins was more sensitive to O-GlcNAcylation inhibition compared with the more dynamic populations. Among the hyperstable population were three core proteins of box C/D small nucleolar ribonucleoprotein complexes (snoRNPs): fibrillarin (FBL), nucleolar protein 5A (NOP56), and nucleolar protein 5 (NOP58). We showed that O-GlcNAcylation stabilized these proteins and was essential for snoRNP assembly. Blocking O-GlcNAcylation on FBL altered the 2′-O-methylation of rRNAs and impaired cancer cell proliferation and tumor formation in vivo.
Board of directors and top management team. CEO relative power and financial returns in Brazil

This article investigates if companies with a stricter control and monitoring system perform better than others in Brazil. The works compares 116 companies in respect to the their independence level between top management team and board directors– being that measured by four parameters, namely, the percentage of independent outsiders in the board, the separation of CEO and chairman, the adoption of contingent compensation and the percentage of institutional investors in the ownership structure – and their financial return measured in terms return on assets (ROA) from the latest Quarterly Earnings release of 2012. Two variables (percentage of outside directors and percentage of institutional investor ownership) are significant in the regression. This paper has provided evidences that the increase in the formal governance structure trough outside directors in the board and ownership by institutional investor might actually lead to worse performance.
Independence, Expertise and Experience of Audit Committees: Some Aspects of Indian Corporate Sector

The current study is based on the review of literature to analyses how independence, expertise and experience of audit committees can influence the quality of financial reporting. After studying a vast and diverse range of literature pertaining to the audit committees and governance issues, an effort has beenmade through this study to demonstrate several aspects of independence of audit committee, for example, informativeness, CEO’s power, frequency of meetings, substitutability and complementarity with alternative corporate governance mechanisms, directors’ share ownership, earning management etc.Similarly a wide range of literature based on utility of financial and accounting knowhow and experience of audit committee members has been reviewed. An attempt is made to establish association litigation risk that the firm faces and market reaction, to the firm’s appointment of audit committee members with accounting and financial expertise and experience. This study also includes the various aspects of audit committee in India, based on regulations, corporate governance reforms and the limited number of empirical research findings. Lack of independence, expertise and experience of audit committees have rendered them less effective in performing their oversight functions. The Companies Bill (2009), a major governance reform, has not become an ‘Act’ as it is delayed due to political apathy, and at the same time some interim reforms have eroded the independence of audit committees even further. There is ad-hocism and vagueness in reference to corporate governance reforms in general and auditing process in particular.
Fast identification of power transformer magnetizing inrush currents based on mathematical morphology and ANN

Discriminating between the magnetizing inrush and the internal fault of a power transform is a major challenge when designing differential transformer protection. In this paper, a novel method, which is based on mathematical morphology (MM) and artificial neural network (ANN), is proposed to solve this problem. Firstly, an MM based stage is used to extract shape features from differential currents, then after a scaling preprocessing which removes magnitude information, the features is fed into an artificial neural network (ANN) to be identified. Using this method, an effective output, which is used to block a false tripping, can be generated slightly longer than half of a period after the occurrence of an inrush condition. By using extracted features instead of raw samples of currents as inputs of an ANN, less inputs are presented to the ANN, which yields a simpler network structure. The computational load required by this method is greatly lower than those which are only based on an ANN, thus it is suitable to be implemented in resource constrained embedded systems. This method has been implemented by using MATLAB and evaluated on the data obtained from PSCAD/EMTDC simulation. The evaluation tests show promising results.
Tight-binding calculation of surface defects in SrTiO3.

uv photoemission experiments on ${\mathrm{SrTiO}}_{3}$(100) surfaces have shown that deep localized levels are associated with a lack of oxygen atoms on these surfaces. Using a tight-binding parametrization of the band structure of ${\mathrm{SrTiO}}_{3}$, together with a Green's-function method, we have calculated the energy levels associated with (100) surfaces, oxygen vacancies in these surfaces, and two kinds of adsorbed Ti atoms. The results of the calculation indicate that the observed deep levels are associated with the adsorbed titanium atoms rather than directly related to the oxygen vacancies.
Moving Object Detection using Temporal Information in Surveillance System using Matlab and ARM7 Processor

The detection of real time video and its application is important and challenging task in video surveillance system. This paper gives the detail idea about the automatic detection of moving object by using the temporal information method from the processing of image sequence from the capture video. This method is efficient in segmentation which is useful for real time video surveillance, object tracking and calculation of its properties like autocorrelation, energy, entropy, correlation, Homogeneity etc. By using the implementation of saliency map on the continuous symmetric frame the difference between the adjacent frames generate the full saliency map with higher saliency value . The final meantime gives saliency value generated for background. The calculation of threshold of area is done by the maximum entropy sum method. The Gaussian Mixture Method followed by the shadow is the common method used for extracting the foreground. This method is useful for removal of noise from the detected object . In the background noise is removed by using by pre-processing and Morphological processing.The final image is obtained by the implementation of Fuzzy logic. Then the basic function the detection of target is controlled by ARM7 controller which is used to display the presence of any moving object, human body or animal. Buzzer circuitry is implemented for security purpose. GSM modem provided the massages to the user about the detection of object . So in this proposed model we detect the moving object using the time domain information and different applications with different function are operated for security purpose using ARM 7 controller.
Fast full state trajectory generation for multirotors

Micro aerial vehicles, such as multirotors, are developed for applications like autonomous monitoring, inspection, and surveillance. Most of the current application scenarios assume a stationary environment and thus, trajectory generation rehes on static targets. In this paper, we address time-optimal trajectory generation in dynamic environments, e.g., for landing on a moving platform. We extend our existing trajectory generation method by the ability to synchronize several axes of motion, following a master/slave approach for individual axes. We further explicitly treat moving targets, like moving landing platforms by planning in a target-centric frame. Our evaluation demonstrates the performance of the method under disturbances. These results have application in dynamic multicopter flight, and also allow for fast and precise multicopter motion under challenging conditions.
MRA of the abdominal aorta and lower extremities

Atherosclerotic involvement of the aorta and lower extremity vessels is a common clinical problem, especially in developed countries. While x‐ray angiography has been the method of choice for preoperative evaluation of patients with atherosclerotic disease, magnetic resonance angiography (MRA) is emerging as a powerful noninvasive tool that is capable of providing information critical to the care of these patients. The objective of this manuscript is to review the current state‐of‐the‐art of MRA of the abdominal aorta and lower extremity vessels. The techniques are described, the clinical indications for MRA are discussed, and the diagnostic accuracy and pitfalls of the various methods are presented. J. Magn. Reson. Imaging 2000;11:32–43. © 2000 Wiley‐Liss, Inc.
Novel Compact Wide-Band EBG Structure Based on Tapered 1-D Koch Fractal Patterns

This letter presents a novel electromagnetic band-gap (EBG) structure in microstrip technology based on nonuniform one-dimensional (1-D) Koch fractal patterns whose dimensions and period are modulated by a tapering function that significantly improves the width of the band-gap. This wide band-gap is achieved by maintaining the radius-to-period (r/a) ratio of the Koch fractal patterns larger than 0.5 in the whole structure. In the passband region, an improved flat response is obtained by tapering the dimensions of the Koch fractal patterns etched in the ground plane, together with the width of the microstrip line, with a Kaiser distribution that also modulates the periodicity of the fractals. A major consequence of this modulation of the periodicity of the pattern is that this structure is much more compact than a uniform conventional one.
Proton release upon glutathione binding to glutathione transferase P1-1: kinetic analysis of a multistep glutathione binding process.

The fate of the thiol proton coming from the ionization of the sulfhydryl group of GSH in the active site of glutathione transferase P1-1 has been studied. pH changes caused by the binding of GSH to the enzyme in the absence of any inorganic buffer indicate that the thiol proton leaves the active site when the binary complex is formed. The amount of protons released is stoichiometric to the amount of GSH thiolate formed in the G-site. The apparent pKa value for the bound GSH, calculated with this potentiometric approach, is 6.18 +/- 0.09; very similar values are found by spectrophotometric (6.20 +/- 0.12) and by kinetic (6.00 +/- 0.08) experiments. Binding of S-hexylglutathione does not cause any proton release. Stopped-flow data obtained by means of an acid-base indicator show that the proton extrusion process (apparent t1/2 = 1.1 +/- 0.1 ms at 15 degrees C) is not rate limiting in turnover (apparent t1/2 = 34 +/- 4 ms at 15 degrees C). By comparing the kinetic behavior of three distinct events occurring during the binding of GSH to the enzyme, i. e. , proton release, ionization of bound GSH and quenching of intrinsic fluorescence, it appears that the binding process follows a multistep mechanism possibly involving the conformational transition of a weak precomplex into the final Michaelis complex. This step is modulated by helix 2 motions and may be rate limiting at physiological GSH concentrations. These findings, coming from kinetic studies, are consistent with NMR data [Nicotra, M. , Paci, M. , Sette, M. , Oakley, A. J., Parker, M. W. , Lo Bello, M. , Caccuri, A. M. , Federici, G. , and Ricci, G. (1998) Biochemistry 37, 3020-3027] and time-resolved fluorescence experiments [Stella, L. , Caccuri, A. M. , Rosato, N. , Nicotra, M. , Lo Bello, M. , De Matteis, F. , Mazzetti, A. P., Federici, G. , and Ricci, G. , manuscript in preparation].
THE TEST-RETEST RELIABILITY OF A STANDARDIZED NEUROCOGNITIVE AND NEUROPHYSIOLOGICAL TEST BATTERY: “NEUROMARKER”

NeuroMarker combines EEG and ERP measures with neurocognitive tests in a fully computerized and standardized testing system. It is designed for use across the lifespan and has a large normative database of over 1,000 subjects. This study was a preliminary evaluation of “NeuroMarker” in subjects spanning four decades. Twenty-one healthy subjects (12–57 years) were tested at baseline and four weeks later. From the “Neuromarker” battery, the authors analyzed EEG data (eyes open and closed) and ERPs elicited during auditory oddball (N100, P200, N200, P300) and working memory (P150, P300) tasks. Concomitant neuropsychological data, acquired using a touch-screen system, comprised measures of sensori-motor, attention, verbal, executive, and memory function. Test-retest data were examined using analyses of variance and correlational procedures (corrected for multiple comparisons), with parallel analyses of age. EEG data did not differ across sessions, and showed high test-retest reliability (.71–.95), particularly for theta and delta (>.85). ERP components also showed sound reliability, particularly for sites where components are maximal: fronto-central N100 (.76–.77), centro-parietal P300 (.78–.81) to oddball targets, N100 and P200 (.74–.86) to oddball non-targets, and P150 amplitude and latency (.84–.93) to working memory stimuli. Neuropsychological tests showed a similarly sound level of consistency (on average, .70), with the most consistent tests tapping simple motor function, estimated intelligence, switching of attention (Part 2), verbal interference response time and memory intrusions (.71–.89). Age and sex did not have a differential impact on reliability for EEG, ERP, or neuropsychology measures. These findings provide preliminary evidence that the “NeuroMarker” battery is reliable for test-retest assessments. The results suggest that the standardized approach has utility for providing sensitive clinical and treatment evaluations across age groups.
Cantharidin‐Based Small Molecules as Potential Therapeutic Agents

Chemical and pharmacological information on cantharidin‐based small molecules was analyzed. The review summarizes new facts about blister beetles' metabolites for the period 2006–2012. General synthetic approaches to cantharidin‐based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models.
A Machine Learning Approach for Layout Inference in Spreadsheets

Spreadsheet applications are one of the most used tools for content generation and presentation in industry and the Web. In spite of this success, there does not exist a comprehensive approach to automatically extract and reuse the richness of data maintained in this format. The biggest obstacle is the lack of awareness about the structure of the data in spreadsheets, which otherwise could provide the means to automatically understand and extract knowledge from these files. In this paper, we propose a classification approach to discover the layout of tables in spreadsheets. Therefore, we focus on the cell level, considering a wide range of features not covered before by related work. We evaluated the performance of our classifiers on a large dataset covering three different corpora from various domains. Finally, our work includes a novel technique for detecting and repairing incorrectly classified cells in a post-processing step. The experimental results show that our approach delivers very high accuracy bringing us a crucial step closer towards automatic table extraction.
Handling spectral variability with alternating angle minimization

We present an algorithm for solving the spectral mixture analysis problem in situations that show spectral variability, represented by spectral libraries for each class of interest. The aim is to select a single optimal endmember candidate from each library, on a per-pixel basis. The algorithm exploits the high dimensionality of spectral data, and is based on an alternating spectral angle minimization scheme. The resulting algorithm is computationally very efficient, and yields excellent results compared to other techniques, such as multiple endmember spectral mixture analysis.
Dealing with misconceptions on the concept of sustainability

Although there is a great degree of acceptance in relation to the importance of pursuing sustainable development, there are some areas within the higher education sector where the concept of sustainability is not yet fully understood. Based on the negative impact misconceptions can have, it is useful to look at the problem and develop approaches to address them. This paper, first delivered at the conference on environmental management systems at universities (EMSU 99) held in Lund, Sweden in May 1999, tries to discuss some of the misconceptions seen in respect of sustainability at universities and suggests some measures aimed at moving ahead.
Muscovite (Mica) Allows the Characterisation of Supported Bilayers by Ellipsometry and Confocal Fluorescence Correlation Spectroscopy

Abstract We demonstrate for the first time that ellipsometry and confocal fluorescence correlation spectroscopy (FCS) are complementary methods for the characterisation of supported planar phospholipid bilayers (SPBs) formed on mica, a mineral used in atomic force microscopy investigations of SPBs. Addition of small unilamellar vesicles containing 20% dioleoylphosphatidylserine (DOPS) and 80% dioleoylphosphatidylcholine (DOPC) to an oxidised borosilicate surface, on the other hand, results in a planar lipid system characterised by lateral diffusion coefficients which are three time smaller than those obtained for SPBs. Moreover, seven labelled phospholipids were tested for their suitability in the FCS characterisation of vesicles as well as of SPBs.
Nonlinear transmission-line model of an FET terahertz detector for arbitrary gate voltage

In this paper, a dynamic nonlinear transmission-line model for a field-effect transistor (FET) is proposed. The model can be used for a field-effect transistor operating as a detector of terahertz waves. Plasma wave excitation and rectification in the channel of a zero drain-source biased FET enables terahertz-wave detection. The terahertz response of the FET can be predicted by solving the telegrapher's equations inside the transistor channel at an arbitrary gate voltage and under non-resonant conditions. At room temperature, the influence of gate voltage on the detector responsivity is investigated. Moreover, the effect of gate bias voltage on the internal equivalent noise power and on the detector responsivity is studied for a typical Si FET.
Dissections of the internal carotid artery: three-dimensional time-of-flight MR angiography and MR imaging features.

S pontaneous dissection of the internal carotid artery is now recognized as one of the most frequent causes of ischemic stroke in young patients; it accounts for as many as 20% of the ischemic strokes that occur in patients who are less than 45 years old I I 1. Approximately 80% of the strokes that are due to internal carotid artery dissection are preceded by warning signs 5-10 days before occurring [2]. Although the clinical signs might be nonspecific such as headache. the neurologic outcome can be grave, depending on the degree of cerebral ischemia. Three-dimensional time-of-flight (TOF) MR angiography and MR imaging are reported to be reliable. noninvasive methods of assessing internal carotid artery dissection [3-5]. Advantages include the availability of an infinite number of projections of the artery. the accessibility of images that allow direct visualization of intramural hematoma, and the ability to assess intracranial circulation and cerebral infarction.
PENGARUH KOMPETENSI, ETIKA, DAN FEE AUDIT TERHADAP KUALITAS AUDIT

This research is to examine to what competence, ethich, and audit fee influence auditors’ quality. The argument of this research background is based on the lack of trust from people in auditors’ quality. The operational variable of competence consists of five indicators; the numbers of client, communications with the client, the accurate timeline in audit completion, knowledge and education, knowledge and training. Ethics consists of six indicators; profesion’s responsibility, public interest, integrity, confidentiality, professional rapport and norms. Audit fee consists of three indicators; the type of industry. Workplace environment, and the reputation of public auditors. The audit’s quality consists of four indicators; error identification, compliance with SPAP, audit program, and attention from manager or partner. The determining of sample in this research is using convenience sampling technical. From the examination result it is got a conclusion that there negative significant influence from competency towards auditor’s quality, while ethic and audit fee have positif significant influence towards auditor’s quality.
Microwave Circuits in Paper Substrates Exploiting Conductive Adhesive Tapes

In this work, a new technique to fabricate microwave circuits in paper substrates is proposed. This technique relies on a copper adhesive tape that is shaped by a photo-lithographic process and then transferred to the hosting substrate by means of a sacrificial layer. Microstrip lines in paper substrates have been electromagnetically characterized accounting also for the adhesive layers. Experimental results show an insertion loss better than 0.6 dB/cm at 10 GHz.