Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of polymorphisms in the elastin gene with sporadic ruptured intracranial aneurysms and unruptured intracranial aneurysms in Chinese patients

It has been suggested that the elastin gene is a candidate gene for the development of intracranial aneurysms (IAs). We investigated the association of single-nucleotide polymorphisms (SNPs) in the elastin gene in sporadic subarachnoid hemorrhage and in patients with unruptured aneurysms in China. We genotyped 446 (47.9%) IA patients (308 ruptured and 138 unruptured) and 485 (52.1%) control subjects for seven exonic and intronic SNPs in the elastin gene and then evaluated their allelic associations with sporadic ruptured and unruptured IAs. We found that IA is associated with two SNPs in the elastin gene: rs2071307 (odds ratio 2.87; 95% confidence interval, 2.26–3.64; p < 0.001) and rs2856728 (odds ratio 2.12; 95% confidence interval, 1.71–2.62; p < 0.001). Furthermore, the minor allele of rs2071307 (allele A) was also associated with IA rupture; 31.3% of patients with ruptured IAs were carriers of the minor allele, whereas only 23.2% of patients with unruptured IAs carried the minor allele (odds ratio 1.51; 95% confidence interval, 1.09–2.10; p = 0.013). In conclusion, our study indicates that the elastin gene may be associated with the formation of IAs, and importantly, that it may also be associated with the rupture of IAs.
A fast convergence mechanism for distance-vector routing protocol

In order to solve the problem of routing protocols using the Distributed Bellman-Ford (DBF) algorithm converge very slowly to the correct routes when link costs increase, and in the case when a set of link failures results in a network partition, we present a new fast converge distance vector routing algorithm CF-DVRP that uses suppression-failure strategy and multiple feasible backups per destination for every node to prevent the count-to-infinity problem. The analysis result show that CF-DVRP provide better network stability and availability and the simulation experiments show that CF-DVRP can deal with the multiple failures effectively.
Synthèse et étude de nouveaux chélateurs sélectifs du cuivre(I) pour les maladies de type Wilson

Le cuivre est un element essentiel a tout etre vivant, il intervient en tant que cofacteur dans de nombreux processus biologiques. Cependant, en exces, il est toxique pour l'organisme et peut impliquer des reactions de type Fenton. Sa concentration dans les cellules est donc regulee par des proteines qui permettent son transport et son elimination. La maladie de Wilson est due a une anomalie au niveau d'une de ces proteines (l'ATP7B). C'est une maladie genetique, dont les deux parents sont porteurs sains. Elle entraine une accumulation du cuivre dans le foie, le cerveau et les yeux. Cette maladie orpheline (1/30 000 a 1/100000) presente des symptomes nombreux et souvent peu specifiques a la maladie de Wilson. Les traitements actuels visent a diminuer l'absorption intestinale ou a augmenter l'excretion urinaire du cuivre et doivent etre suivis a vie. Ils ne visent absolument pas le foie qui est le premier organe touche et sont peu selectifs du cuivre. Actuellement, il n'existe pas de traitement capable d'eliminer le cuivre directement au niveau du foie qui est le premier organe touche. Une molecule capable d'eliminer le cuivre en exces contenu dans les cellules du foie (hepatocytes) serait donc tres utile pour soulager les malades. Pour cela, nous avons concu des vecteurs comportant une partie ciblante pour pouvoir cibler le foie et une partie chelatante pour complexer le cuivre(I). Cette partie chelatante presente une forte affinite pour le cuivre(I) et une forte selectivite Cu+/Zn2+. Ainsi, deux modeles de parties chelatantes bases sur deux et trois cysteines ont ete synthetises et des etudes de complexation du cuivre(I) mais aussi d'autres metaux divalents de configuration d10 ont ete realises. Enfin, la vectorisation de ces modeles a ete realisee et des tests cellulaires ont ete faits afin d'evaluer la complexation des ces vecteurs pour le cuivre(I) intracellulaire.
7-Chloro-4-[(E)-N′-(4-fluorobenzylidene)hydrazinyl]quinoline monohydrate

The molecule of the title hydrate, C16H11ClFN3·H2O, is slightly twisted, as indicated by the dihedral angle of 9.55 (10)° formed between the quinoline ring system and the benzene ring. The conformation about the C=N double bond is E, and the amine-H atom is oriented towards the quinoline residue. In the crystal structure, the water molecule accepts an N—H⋯O and makes two O—H⋯Nquinoline hydrogen bonds, generating a two-dimensional array in the ab plane, which is further stabilized by C—H⋯O interactions. The most significant contacts between layers are of the type C—H⋯F.
Personalized modeling and sentiment analyzing on Chinese micro-blog posts

Trying to understand the sentiment of the human has always been the goal of artificial intelligence. But mining opinions and analyzing the sentiment information in internet is an ongoing challenge. The obstacles to the analysis of Chinese micro-blog are not only their very brief content, but also the lack of a suitable model of blogger personality to support it. This paper focuses on personalized modeling and sentiment analysis on Chinese Micro-blog posts. The main contribution of this paper is to take more comprehensive factors into consideration in the process of building personalized blogger model, which is used to assist and rectify the results calculated by sentiment analysis based on dynamic weighting adjustment. The experimental results also show the feasibility of the approach, and existing problems and future works are also present in the end.
Evaluation of the Quality of Antenatal Care (ANC) Service at Higher 2 Health Center in Jimma, South West Ethiopia

Background: Antenatal care is the care that women receive during pregnancy to ensure a healthy outcome for women and newborns. In spite of its clear importance, such services continued to be important determinants of maternal mortality and morbidity throughout the world. Methods: A case study was conducted in Higher 2 Town Health Center, using client exit interviews of 265 clients who came to the health institution. In addition, 10 observations of client-provider interac- tions, document reviews of 246 clients' documents selected by systematic random sampling tech- nique, and 5 in-depth interviews of the focal persons were conducted. Quantitative data were analyzed using SPSS for windows (SPSS 16.0). Qualitative data were categorized into major the- matic areas and presented as narratives in triangulation with the quantitative results. In each evaluation dimension, indicators were used to judge the quality of antenatal care services. Results: Most of the minimum required basic resources recommended by World Health Organization were available in the study site. But there were incomplete sets of laboratory reagents and shortage of some drugs. Comprehensive history was recorded for 93.4% of clients. Only 34.3% of clients re- ceived prescriptions for iron supplementation. Majority (94.6%) of the clients were satisfied with the accommodations of antenatal care service. The compliance of the health care providers to- wards routine laboratory investigations ranged from 25.4% to 50.1%. Conclusions: The overall quality of the service was judged as fair (69.5%). Majority of the clients were satisfied with ac- commodation of ANC services. However, the availability of laboratory reagents and drugs re- mained to be challenges. Providers' compliance towards standard basic investigations was also far below World Health Organization recommendations and judged as critical. Thus it is recom- mended that responsible bodies should strive to improve provision of supplies and compliance of the care providers to step-up the quality of care at president capacity level. * Corresponding author.
Effect of structure on the tribology of ultrathin graphene and graphene oxide films

The friction and wear properties of graphene and graphene oxide (GO) with varying C/O ratio were investigated using friction force microscopy. When applied as solid lubricants between a sliding contact of a silicon (Si) tip and a SiO2/Si substrate, graphene and ultrathin GO films (as thin as 1–2 atomic layers) were found to reduce friction by ∼6 times and ∼2 times respectively as compared to the unlubricated contact. The differences in measured friction were attributed to different interfacial shear strengths. Ultrathin films of GO with a low C/O ratio of ∼2 were found to wear easily under small normal load. The onset of wear, and the location of wear initiation, is attributed to differences in the local shear strength of the sliding interface as a result of the non-homogeneous surface structure of GO. While the exhibited low friction of GO as compared to SiO2 makes it an economically viable coating for micro/nano-electro-mechanical systems with the potential to extend the lifetime of devices, its higher propensity for wear may limit its usefulness. To address this limitation, the wear resistance of GO samples with a higher C/O ratio (∼4) was also studied. The higher C/O ratio GO was found to exhibit much improved wear resistance which approached that of the graphene samples. This demonstrates the potential of tailoring the structure of GO to achieve graphene-like tribological properties.
Context-aware brain–computer interfaces: exploring the information space of user, technical system and environment

Brain–computer interface (BCI) systems are usually applied in highly controlled environments such as research laboratories or clinical setups. However, many BCI-based applications are implemented in more complex environments. For example, patients might want to use a BCI system at home, and users without disabilities could benefit from BCI systems in special working environments. In these contexts, it might be more difficult to reliably infer information about brain activity, because many intervening factors add up and disturb the BCI feature space. One solution for this problem would be adding context awareness to the system. We propose to augment the available information space with additional channels carrying information about the user state, the environment and the technical system. In particular, passive BCI systems seem to be capable of adding highly relevant context information—otherwise covert aspects of user state. In this paper, we present a theoretical framework based on general human–machine system research for adding context awareness to a BCI system. Building on that, we present results from a study on a passive BCI, which allows access to the covert aspect of user state related to the perceived loss of control. This study is a proof of concept and demonstrates that context awareness could beneficially be implemented in and combined with a BCI system or a general human–machine system. The EEG data from this experiment are available for public download at www.phypa. org.
Molecular typing and epidemiology of enteroviruses identified from an outbreak of aseptic meningitis in Belgium during the summer of 2000

Non‐polio enteroviruses are the most common cause of aseptic meningitis worldwide. From May to September 2000, a major outbreak of aseptic meningitis occurred in Belgium. Cerebrospinal fluid samples (CSF) of 122 patients were found to contain enterovirus RNA using diagnostic RT‐PCR that targeted a 231‐bp gene fragment in the 5′ noncoding region. In addition, a molecular typing method was developed based on RT‐nested PCR and sequencing directly from CSFa 358‐bp fragment in the aminoterminal part of the VP1 capsid protein. To identify the enterovirus type, nucleotide sequences of the VP1 amplicons were compared to all the enterovirus VP1 sequences available in GenBank. Echovirus 30 (31.2%), echovirus 13 (23.8%), and echovirus 6 (20.5%) were identified most frequently during the epidemic. Coxsackievirus B5 was present in 15.6% of the samples, and could be subdivided in two distinct epidemic clusters, coxsackievirus B5a (10.7%) and B5b (4.9%). Other enteroviruses encountered were echovirus 16 (5.7%), echovirus 18 (1.6%), coxsackievirus B4 (0.8%) and echovirus 7 (0.8%). The high prevalence of echovirus 13, considered previously a rare serotype, indicates it is an emerging epidemic type. To verify the typing results and to explore further the intratypical genetic variation, phylogenetic analysis was carried out. Geographical clustering of most of the strains within each type and subtype could be observed. The RT‐nested PCR strategy, carried out directly on clinical samples, is a simple and rapid method for adequate molecular typing of the Group B enteroviruses causing aseptic meningitis. J. Med. Virol. 70:420–429, 2003. © 2003 Wiley‐Liss, Inc.
Probabilistic Models for 3D Urban Scene Understanding from Movable Platforms

This work is a contribution to understanding multi-object traffic scenes from video sequences. All data is provided by a camera system which is mounted on top of the autonomous driving platform AnnieWAY. The proposed probabilistic generative model reasons jointly about the 3D scene layout as well as the 3D location and orientation of objects in the scene. In particular, the scene topology, geometry as well as traffic activities are inferred from short video sequences.
[Initial therapeutic trials of an antibilharzial agent, 35 972 R.P. in man].

35,972 R. P. is a new schistosomicidal drug deriving from a thione dithiole pyrazinyl basic structure. It has been assessed with 125 patients suffering from an urinary tract schistosomiasis (69 cases) or from an intestinal schistosomiasis (56 cases). Five regimens have been followed. The last one was 1.50 g/day over 3 days and it included 75 patients. The clinical tolerance was satisfactory although vomiting was reported in 16 % cases and headaches were noted in 21 % cases. The efficiency was remarkable as 97 % patients were cured. New studies are been performed on a one day treatment basis.
Characterizations of Narrowband MIMO Channels

Computational electromagnetics are useful for examining communication link performance in complex propagation environments. In this paper we illustrate how different characterizations of narrowband multiple-input multiple-output (MIMO) channels, including the mutual information, received power, and effective rank, behave as a function of location. Large-scale simulation results are presented for a 7x7 MIMO system operating in an outdoor urban area. We find that the differences between MIMO channels are more visible when the effects of path loss are removed from the calculations.
Speed Estimation of PM Stepper Motors. Robustness Aspects

This work deals with speed estimation in electric drives that include a Permanent Magnet Stepper Motor. On the one hand a nonlinear observer is designed, whereas on the other hand the rotor speed is estimated by using the dirty derivative from the measured position. By assuming model uncertainty and noisy measurements a comparison from the robustness point of view is presented. Advantages and disadvantages of both techniques are commented.
Study of the mechanism and rate of exciton dissociation at the donor-acceptor interface in bulk-heterojunction organic solar cells

In this paper, a comprehensive study is carried out on the dissociation mechanism of excitons in bulk-heterojunction organic solar cells. It is proposed that at the donor-acceptor interface, a Frenkel exciton relaxes to a charge transfer exciton and then dissociates into free charge carriers with the aid of molecular vibrational energy. The interaction operator between the charge transfer exciton and molecular vibrational energy is derived and used to formulate and calculate the rates of dissociation of singlet and triplet excitons into free charge carriers. The dissociation rates are found to be dependent on the binding energy, lowest unoccupied molecular orbital offset between the donor and acceptor, the phonon energy, reduced excitonic mass, excitonic Bohr radius, and the dielectric constant of the organic material. Using the proposed dissociation mechanism, three points have also been highlighted that could provide possible reasons as to why the performance of bulk-heterojunction organic solar cell is low.
Low complexity implementation of block diagonalization algorithm in 3D MU-MIMO systems

In three dimension multiple-input multiple-output (3D MIMO) systems, large number of antennas are arranged at base station (BS) to obtain high spectral efficiency and large throughput. But increase of BS antennas also enhances the computational complexity of the multiuser precoding algorithm such as block diagonalization (BD) significantly. For the dimension increase of channel matrix, various ways can be chosen to obtain the equivalent matrix which can eliminate the user interference completely in the regular BD algorithm. Motivated by this observation, a low complexity precoding method based BD is proposed in this paper, which can simplify the procedure of the two singular value decomposition (SVD) operations in the regular BD algorithm prominently with the optimal equivalent matrix. Also with the 3D channel measurement data we validate the 3D capacity performance of the proposed method. Simulation results show that the proposed method can achieve the same capacity as the regular BD algorithm.
Development of an in vitro Batch-type Closed Gas Exposure Device with an Alveolar Epithelial Cell Line, A549, for Toxicity Evaluations of Gaseous Compounds

To simply evaluate toxicity for various types of exhaust-gas samples collected in various locations, we developed a small-scale (150 mL) batch-type completely closed gas exposure device incorporated with an air-liquid interface culture of a human alveolar epithelial cell line, A549. On the basis of cell viability tests using an acid phosphatase assay after 48 h of gas exposure, the developed device was able to measure clear dose-response relationships for volatile organic and inorganic compounds, such as benzene, trichloroethylene (TCE), acetone, SO_2 and NO_2 gases, but not CO gas. Although the 50% effective concentration values in the device were much higher than 50% lethal concentration values reported in animal experiments, the tendency of the toxic intensity observed in the former was roughly consistent with that of the acute toxicity in the latter. We further applied the device to evaluate the toxicity of cigarette smoke as an example of actual environmental gases, and successfully measured acute cell death from the gas after 48 h of exposure. The present small device is expected to be one of good tools not only in simultaneously assessing various gaseous chemicals or samples, but also in studying acute toxicity expression mechanisms in human lung epithelia.
Is a prolonged second stage of labor too long?

Professional guidelines define the second stage of labor as ‘prolonged’ at three hours for primiparous women with an epidural and two hours without, and at two hours for parous women with an epidural and one hour without(1). NICE guidelines from the UK define second stage length similarly, but take into consideration passive time at full cervical dilation and the time in active pushing(2).
Global stability properties of renewal epidemic models

We investigate the global dynamics of a general Kermack-McKendrick-type epidemic model formulated in terms of a system of renewal equations. Specifically, we consider a renewal model for which both the force of infection and the infected removal rates are arbitrary functions of the infection age, $\tau$, and use the direct Lyapunov method to establish the global asymptotic stability of the equilibrium solutions. In particular, we show that the basic reproduction number, $R_0$, represents a sharp threshold parameter such that for $R_0\leq 1$, the infection-free equilibrium is globally asymptotically stable; whereas the endemic equilibrium becomes globally asymptotically stable when $R_0 > 1$, i.e. when it exists.
Structured Large Margin Machine Ensemble

Large margin classifiers have been widely applied in solving supervised learning problems. One representative model in large margin learning is the support vector machine (SVM). SVM is an unstructured classifier since the data structure information is underutilized and the decision hyperplane calculation relies exclusively on the support vectors. To incorporate the data covariance information into the large margin learning, structured large margin machine (SLMM) is recently proposed and show better performance than classical SVM in some applications. Instead of utilizing the data structures straightly like SLMM, SVM ensemble (SVMe) improves the generalization ability of SVM in another way by combining the outputs of a series of SVMs. Inspired by SVMe, we are going to explore the ensemble counterpart for SLMM, i.e., SLMMe, and validate the effectiveness of multiple SLMM system. Experimental results on benchmark datasets demonstrate that SLMMe improves SLMM by reducing its variance, and SLMMe outperforms SVMe in most cases in terms of both classification accuracy and variance.
Danish registers on personal income and transfer payments

Introduction: The Income Statistics Register provided by Statistics Denmark is the key register describing the income composition of the entire Danish population starting in 1970. Content: The register contains more than 160 variables including salaries, entrepreneurial income, taxes, public transfer payments, capital income, private pension contributions, and payouts. In addition, Statistics Denmark provide more detailed registers on specific income transfers, including sickness benefit, old age pension, disability pension, and cash and unemployment benefits. Validity and coverage: The income data are generally of high quality, but for variables not relevant for administrators the quality may be lower. Conclusion: The registers on income and transfer payments include many variables on the income composition.
Image Registration in Intra-oral Radiography

Image registration is one of the image processing methods which is widely used in computer vision, pattern recognition, and medical imaging. In digital subtraction radiography, image registration is one of the important prerequisites to match the reference and subsequent images. In this paper, we propose an automatic non-rigid registration method namely curvature-based registration that relies on a curvature based penalizing term and its application on dental radiography. The regularizing term of this intensity-based registration approach provides affine linear transformation so that pre-registration step is no longer necessary. This leads to faster and more reliable solutions. The implementation of this approach is based on the numerical solution of the underlying Euler-Lagrange equations. In addition, a comparison between this algorithm and linear alignment method (LAM) with 20 image pairs is presented
Plasma Carotenoid Concentrations before and after Supplementation with Astaxanthin in Middle-Aged and Senior Subjects

A randomized, double-blind human trial was conducted to assess the effect on the plasma carotenoid concentration of 4- or 12-week astaxanthin supplementation (1 or 3 mg/d) of 20 Japanese middle-aged and senior subjects. The plasma carotenoid concentration was significantly higher after the astaxanthin supplementation than that before in both the 1 mg/d (10 subjects) and 3 mg/d (10 subjects) groups.
Paris et l’automobile : un siècle de passions

Tout au long du XXe siecle, l’automobile a ete le symbole de la modernite. Mais l’originalite de cet ouvrage1 reside moins dans l’analyse de cet objet qui fut par ailleurs associe a l’image de l’ascension sociale que sur son articulation a la ville et notamment a la ville de Paris. L’etude privilegie en fait une analyse de la mobilite des Parisiens en la replacant dans une dimension historique. L’ouvrage est structure en trois parties correspondant a trois phases historiques : la periode avan.