Miracle-dz/UniFAR-FTUs huggingface dataset:
UvA-DARE ( Digital Academic Repository ) Phenotype and genotype in 17 patients with Goltz-Gorlin syndrome

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Multi-Feature Likelihood Ratio Detection Algorithm Based on Random Point Patterns

This paper focuses on the random point pattern detection problems. Based on the characteristics of random point patterns, a multi-feature likelihood ratio random point pattern detection algorithm is proposed. This algorithm first utilizes Monte Carlo experiments to estimate the likelihood ratio and detection threshold of the distribution parameters of random point patterns. Then, it discriminates the input data to achieve the detection of random point patterns.
Set target aggregation of multiple mechanical systems

In this paper, we study the set target aggregation problem of multiple mechanical systems. Each system is modeled by a Lagrangian dynamical equation and observes a convex set as its local target. The objective of the group is to reach an aggregation towards these target sets.We propose a set target aggregation algorithm that is constructed based on each mechanical system's own target sensing and the exchange of its information with local neighbors. With necessary connectivity for both fixed and switching communication topologies, multiple mechanical systems are shown to converge to the intersection of all the local target sets while the vectors of generalized coordinate derivatives are driven to zero. Simulations are given to validate the theoretical results.
Simulation of Human Motion Data using Short‐Horizon Model‐Predictive Control

Many data‐driven animation techniques are capable of producing high quality motions of human characters. Few techniques, however, are capable of generating motions that are consistent with physically simulated environments. Physically simulated characters, in contrast, are automatically consistent with the environment, but their motions are often unnatural because they are difficult to control. We present a model‐predictive controller that yields natural motions by guiding simulated humans toward real motion data. During simulation, the predictive component of the controller solves a quadratic program to compute the forces for a short window of time into the future. These forces are then applied by a low‐gain proportional‐derivative component, which makes minor adjustments until the next planning cycle. The controller is fast enough for interactive systems such as games and training simulations. It requires no precomputation and little manual tuning. The controller is resilient to mismatches between the character dynamics and the input motion, which allows it to track motion capture data even where the real dynamics are not known precisely. The same principled formulation can generate natural walks, runs, and jumps in a number of different physically simulated surroundings.
A Full SW-HW Demonstration of GEMM Accelerators with RISC-V Instruction Extensions

Many deep learning accelerators have been proposed and designed in both academia and industry for executing deep neural networks with better power efficiency. Recently, many studies focus on developing a system-on-chip including both host processor and accelerators. In this paper, we demonstrate a full software-hardware stack for accelerating deep learning benchmarks using a co-processor attached to RISC-V core. To do so, we extend the RISC-V instruction set and modified the compilation stack to show significant end-to-end performance boost compared to the CPU-only processing scenario.
Evaluating the Wiimote as a Musical controller

The Nintendo Wiimote is growing in popularity with mu-sicians as a controller. This mode of use is an adaptationfrom its intended use as a game controller, and requiresevaluation of its functions in a musical context in orderto understand its possibilities and limits. Drawing on Hu-man Computer Interaction methodology, we assessed thecore musical applications of the Wiimote and designeda usability experiment to test them. 17 participants tookpart, performing musical tasks in four contexts: trigger-ing; precise and expressive continuous control; and ges-ture recognition. Interviews and empirical evidence wereutilised to probe the device’s limitations and its creativestrengths. This study should help potential users to planthe Wiimote’s employment in their projects, and should beuseful as a case study in HCI evaluation of musical con-trollers.
Governance of Value Creation in Supply Chain Relationships

This article is an empirical attempt to examine the relationship between types of governance and value creation in supply chain relationships. It does this by examining the incentive systems associated with various forms of governance and their effects on information sharing and on logistical performance. The article presents structural equation modelling (SEM) analysis of survey data from 181 supply chain relationships in the seafood industry. Contrary to common assumptions, the study findings suggest that relational governance affect value creation more than does market and hierarchical governance. The present study makes an empirical contribution by investigating the antecedents of logistical performance by applying SEM techniques.
Radon in residences: influences of geological and housing characteristics.

222Rn is a radioactive gas emitted during the decay of 238U. 222Rn is a recognized lung carcinogen in humans and a common indoor air contaminant. This paper describes the results of research undertaken in 894 residences of the Province of Quebec (Canada), in which one of the objectives was to evaluate the influence of geological and housing characteristics on 222Rn levels. After a random selection of homes, 222Rn concentrations were measured with alpha track detectors in the basement and the main bedroom during two consecutive 6-mo periods. Geological subsoil characteristics were determined from various sources (e.g., geological maps, databanks on uranium sampling in lake and stream sediments), and housing characteristics were documented with a questionnaire. Statistical variance analysis of data indicates that geological factors only explain 5% and 4.5% of the variations in 222Rn concentrations, respectively, in the basement and on the first floor. When variables relative to housing characteristics are added, the analysis explains only 18% and 15% of the variations in 222Rn concentrations in the basement and on the first floor. These results illustrate the difficulties in predicting 222Rn concentrations in homes.
Disadvantaged Minorities in Self-Employment

T WO GENERATIONS of social scientists have described self employment as an economic anachronism in the process of disappearance (Lynd and Lynd 1937: 69; Mayer 1947; Vidich and Bensman 1960: 305-306; Castles and Kosack 1973: 465; Weber 1947: 427). Following Marx on this point, they observed that urbanization and the concentration of firms into ever larger units has continuously reduced the once numerous class of free enterprisers in the last century (Corey 1964: 371). Indeed, a quarter-century ago, Mills (1951;
Vertical Distribution of Bacterial Community Diversity and Water Quality during the Reservoir Thermal Stratification

Reservoir thermal stratification drives the water temperature and dissolved oxygen gradient, however, the characteristic of vertical water microbial community during thermal stratification is so far poorly understood. In this work, water bacterial community diversity was determined using the Illumina Miseq sequencing technique. The results showed that epilimnion, metalimnion and hypolimnion were formed steadily in the JINPEN drinking water reservoir. Water temperature decreased steadily from the surface (23.11 °C) to the bottom (9.17 °C). Total nitrogen ranged from 1.07 to 2.06 mg/L and nitrate nitrogen ranged from 0.8 to 1.84 mg/L. The dissolved oxygen concentration decreased sharply below 50 m, and reached zero at 65 m. The Miseq sequencing revealed a total of 4127 operational taxonomic units (OTUs) with 97% similarity, which were affiliated with 15 phyla including Acidobacteria, Actinobacteria, Armatimonadetes, Bacteroidetes, Caldiserica, Chlamydiae, Chlorobi, Chloroflexi, Cyanobacteria, Firmicutes, Gemmatimonadetes, Nitrospirae, Planctomycetes, Proteobacteria, and Verrucomicrobia. The highest Shannon diversity was 4.41 in 45 m, and the highest Chao 1 diversity was 506 in 5 m. Rhodobacter dominated in 55 m (23.24%) and 65 m (12.58%). Prosthecobacter dominated from 0.5 to 50 m. The heat map profile and redundancy analysis (RDA) indicated significant difference in vertical water bacterial community composition in the reservoir. Meanwhile, water quality properties including dissolved oxygen, conductivity, nitrate nitrogen and total nitrogen have a dramatic influence on vertical distribution of bacterial communities.
Population-based study of lung function and incidence of heart failure hospitalisations

Background Reduced forced expiratory volume (FEV1) and forced vital capacity (FVC) are risk factors for myocardial infarction (MI) and stroke. However, the relationship with incidence of heart failure (HF) is incompletely known. This population-based study explored whether reduced FEV1 or FVC is associated with the incidence of hospitalisation for HF. Methods 20 998 men (mean age 43 years) with no history of MI or stroke were examined with spirometry in 1974–84. The incidence of hospitalisation due to HF was studied over a mean follow-up of 23 years in relation to age- and height-adjusted FEV1 and FVC. Results 725 incident HF hospitalisations occurred during the follow-up period, 503 of them without a previous or concurrent diagnosis of MI. In non-smokers the risk factor-adjusted hazard ratio (HR) for HF hospitalisation was 1.25 (95% CI 1.11 to 1.40) and 1.26 (95% CI 1.13 to 1.42), respectively, per 1SD lower FEV1 and FVC. The corresponding risk factor-adjusted HRs in smokers were 1.32 (95% CI 1.21 to 1.45) and 1.22 (95% CI 1.11 to 1.33), respectively, for FEV1 and FVC. This relationship was consistent in men with and without hypertension, in men above and below the median age of 44 years and for HF events without previous or concurrent MI. Exclusion of cases with a diagnosis of chronic obstructive pulmonary disease during the follow-up period did not substantially change the results. Conclusion In this long-term population-based study of men, moderately reduced FEV1 and FVC were associated with an increased incidence of hospitalisations due to HF.
Current status and prospects of atmosphere radiosounding systems

Historical background is given, the analysis of current state is performed and the ways of further development of atmosphere radiosounding systems are presented. Alongside with the prospects, the advisability of developing and implementing the digital mobile system using the signals of satellite navigation GLONASS/GPS platform for tracking radiosounding and determining its location, as well as direction and speed of wind is pointed out. Another prospect deals with the modernization of existing systems through the use of microwave autodyne oscillators as miniature and low-cost transceivers - the responder of request radar signals.
Defective Secretion of Saliva in Transgenic Mice Lacking Aquaporin-5 Water Channels*

Aquaporin-5 (AQP5) is a water-selective transporting protein expressed in epithelial cells of serous acini in salivary gland. We generated AQP5 null mice by targeted gene disruption. The genotype distribution from intercross of founder AQP5 heterozygous mice was 70:69:29 wild-type:heterozygote:knockout, indicating impaired prenatal survival of the null mice. The knockout mice had grossly normal appearance, but grew ∼20% slower than litter-matched wild-type mice when placed on solid food after weaning. Pilocarpine-stimulated saliva production was reduced by more than 60% in AQP5 knockout mice. Compared with the saliva from wild-type mice, the saliva from knockout mice was hypertonic (420 mosm) and dramatically more viscous. Amylase and protein secretion, functions of salivary mucous cells, were not affected by AQP5 deletion. Water channels AQP1 and AQP4 have also been localized to salivary gland; however, pilocarpine stimulation studies showed no defect in the volume or composition of saliva in AQP1 and AQP4 knockout mice. These results implicate a key role for AQP5 in saliva fluid secretion and provide direct evidence that high epithelial cell membrane water permeability is required for active, near-isosmolar fluid transport.
Biological Entity Recognition with Conditional Random Fields

Due to the rapid evolution of molecular biology and the lack of naming standards, biological entity recognition (BER) remains a challenging task for information extraction and natural language understanding. In this study, we presented a statistical machine learning approach for extracting features, modeling, and predicting biological named entities. Our approach utilizes UMLS semantic types together with MetaMap, SemRep, and ABGene, as well as the conditional random fields (CRF) framework, and learns both the structure and parameters of a statistical model. Results of this study are competitive with the results of the state of the art tools in this field. Unlike competing similar approaches, the presented method is fully automatic, hence more generalizable and directly transferable to other named entity recognition (NER) problems in medical informatics.
ATLAS: Automatic Temporal Segmentation and Annotation of Lecture Videos Based on Modelling Transition Time

The number of lecture videos available is increasing rapidly, though there is still insufficient accessibility and traceability of lecture video contents. Specifically, it is very desirable to enable people to navigate and access specific slides or topics within lecture videos. To this end, this paper presents the ATLAS system for the VideoLectures.NET challenge (MediaMixer, transLectures) to automatically perform the temporal segmentation and annotation of lecture videos. ATLAS has two main novelties: (i) a SVMhmm model is proposed to learn temporal transition cues and (ii) a fusion scheme is suggested to combine transition cues extracted from heterogeneous information of lecture videos. According to our initial experiments on videos provided by VideoLectures.NET, the proposed algorithm is able to segment and annotate knowledge structures based on fusing temporal transition cues and the evaluation results are very encouraging, which confirms the effectiveness of our ATLAS system.
EVIDENCE FOR WARPED DISKS OF YOUNG STARS IN THE GALACTIC CENTER

The central parsec around the supermassive black hole in the Galactic center (GC) hosts more than 100 young and massive stars. Outside the central cusp (R ∼ 1″) the majority of these O and Wolf–Rayet (W–R) stars reside in a main clockwise system, plus a second, less prominent disk or streamer system at large angles with respect to the main system. Here we present the results from new observations of the GC with the AO-assisted near-infrared imager NACO and the integral field spectrograph SINFONI on the ESO/VLT. These include the detection of 27 new reliably measured W–R/O stars in the central 12″ and improved measurements of 63 previously detected stars, with proper motion uncertainties reduced by a factor of 4 compared to our earlier work. Based on the sample of 90 well measured W–R/O stars, we develop a detailed statistical analysis of their orbital properties and orientations. We show that half of the W–R/O stars are compatible with being members of a clockwise rotating system. The rotation axis of this system shows a strong transition from the inner to the outer regions as a function of the projected distance from Sgr A*. The main clockwise system either is either a strongly warped single disk with a thickness of about 10°, or consists of a series of streamers with significant radial variation in their orbital planes. Eleven out of 61 clockwise moving stars have an angular separation of more than 30° from the local angular momentum direction of the clockwise system. The mean eccentricity of the clockwise system is 0.36 ± 0.06. The distribution of the counterclockwise W–R/O star is not isotropic at the 98% confidence level. It is compatible with a coherent structure such as stellar filaments, streams, small clusters or possibly a disk in a dissolving state: 10 out of 29 counterclockwise moving W–R/O stars have an angular separation of more than 30° from the local angular momentum direction of the counterclockwise system. The observed disk warp and the steep surface density distribution favor in situ star formation in gaseous accretion disks as the origin of the young massive stars.
Evaluating Power Management Strategies for High Performance Memory ( DRAM ) : A Case Study for Achieving Effective Analysis by Combining Simulation Platforms and Real Hardware Performance Monitoring

Developing dynamic power management strategies for high performance systems requires a good understanding of the power-performance trade-offs underlining the workload-strategy-system interactions. The feasibility of detailed simulations to help here is severely limited by the range of problem sizes that can be simulated and simulation speed. For our work we want to understand the effectiveness of DRAM power management for a 'realistic' workload RF-CTH about 500K lines of Fortran-C benchmark developed at Sandia National Labs. The target architecture is a CMP-based building block for a future high performance computing architecture. We address the scalability and speed limitations for detailed simulation by adopting a multistep characterization and simulation approach incorporating analysis on current generation hardware using processor performance counters, a fast memory hierarchy simulation engine, a detailed system-level simulator and a power-performance simulator for the DRAM subsystem.
Investigating the halochromic properties of azo dyes in an aqueous environment by using a combined experimental and theoretical approach.

The halochromism in solution of a prototypical example of an azo dye, ethyl orange, was investigated by using a combined theoretical and experimental approach. Experimental UV/Vis and Raman spectroscopy pointed towards a structural change of the azo dye with changing pH value (in the range pH 5-3). The pH-sensitive behavior was modeled through a series of ab initio computations on the neutral and various singly and doubly protonated structures. For this purpose, contemporary DFT functionals (B3LYP, CAM-B3LYP, and M06) were used in combination with implicit modeling of the water solvent environment. Static calculations were successful in assigning the most-probable protonation site. However, to fully understand the origin of the main absorption peaks, a molecular dynamics simulation study in a water molecular environment was used in combination with time-dependent DFT (TD-DFT) calculations to deduce average UV/Vis spectra that take into account the flexibility of the dye and the explicit interactions with the surrounding water molecules. This procedure allowed us to achieve a remarkable agreement between the theoretical and experimental UV/Vis spectrum and enabled us to fully unravel the pH-sensitive behavior of ethyl orange in aqueous environment.
Epstein-Barr Virus Transcytosis through Polarized Oral Epithelial Cells

ABSTRACT Although Epstein-Barr virus (EBV) is an orally transmitted virus, viral transmission through the oropharyngeal mucosal epithelium is not well understood. In this study, we investigated how EBV traverses polarized human oral epithelial cells without causing productive infection. We found that EBV may be transcytosed through oral epithelial cells bidirectionally, from both the apical to the basolateral membranes and the basolateral to the apical membranes. Apical to basolateral EBV transcytosis was substantially reduced by amiloride, an inhibitor of macropinocytosis. Electron microscopy showed that virions were surrounded by apical surface protrusions and that virus was present in subapical vesicles. Inactivation of signaling molecules critical for macropinocytosis, including phosphatidylinositol 3-kinases, myosin light-chain kinase, Ras-related C3 botulinum toxin substrate 1, p21-activated kinase 1, ADP-ribosylation factor 6, and cell division control protein 42 homolog, led to significant reduction in EBV apical to basolateral transcytosis. In contrast, basolateral to apical EBV transcytosis was substantially reduced by nystatin, an inhibitor of caveolin-mediated virus entry. Caveolae were detected in the basolateral membranes of polarized human oral epithelial cells, and virions were detected in caveosome-like endosomes. Methyl β-cyclodextrin, an inhibitor of caveola formation, reduced EBV basolateral entry. EBV virions transcytosed in either direction were able to infect B lymphocytes. Together, these data show that EBV transmigrates across oral epithelial cells by (i) apical to basolateral transcytosis, potentially contributing to initial EBV penetration that leads to systemic infection, and (ii) basolateral to apical transcytosis, which may enable EBV secretion into saliva in EBV-infected individuals.
Temporary employment in Italy and its consequences on gender

Purpose – The purpose of this paper was to establish whether precariousness of life as determined by temporary employment contributed to anxiety and depression and whether its consequences on daily life were differentiated in relation to gender.Design/methodology/approach – A structural equation analysis of anxiety and depression with aspects of precariousness of life as model predictors was explored with t‐test and correlation analyses used to explore gender differences in the study variables.Findings – The structural equation model produced strong evidence to suggest that precariousness of life was a significant predictor of both anxiety and depression. Women reported significantly higher scores than men on distrust toward the professional future and the emotional consequences on everyday life, anxiety and depression. As hypothesized, the negative consequences of temporary work in personal and family life appear more evident in women.Practical implications – The results suggest that organizations should.