Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of an eye-gaze controlled interface for surgical manipulators using eye-tracking glasses

Introducing robots into the operating theatre has become more popular in recent decades. Surgical manipulators have been developed to assist in surgeries like a human assistant to facilitate the surgical procedures. In this paper, we present an eye-controlled interface for the surgeon to control this kind of robot based on eye-tracking glasses. In our approach, we use the monitor for providing the endoscopic/laparoscopic feedback as the landmark for controlling the robot. The surgeon is allowed to control the robot by looking at different features of the monitor. We present the algorithm for extracting the monitor from the user's view and the method on how to differentiate the control commands with the detected monitor and the user's gaze-point. Experiments were conducted to verify the feasibility of our eye-controlled interface.
What links BRAF to the heart function? new insights from the cardiotoxicity of BRAF inhibitors in cancer treatment

The RAS-related signalling cascade has a fundamental role in cell. It activates differentiation and survival. It is particularly important one of its molecules, B-RAF. B-RAF has been a central point for research, especially in melanoma. Indeed, it lacked effective therapeutic weapons since the early years of its study. Molecules targeting B-RAF have been developed. Nowadays, two classes of molecules are approved by FDA. Multi-target molecules, such as Sorafenib and Regorafenib, and selective molecules, such as Vemurafenib and Dabrafenib. Many other molecules are still under investigation. Most of them are studied in phase 1 trials. Clinical studies correlate B-RAF inhibitors and QT prolongation. Though this cardiovascular side effect is not common using these drugs, it must be noticed early and recognize its signals. Indeed, Oncologists and Cardiologists should work in cooperation to prevent lethal events, such as fatal arrhythmias or sudden cardiac death. These events could originate from an uncontrolled QT prolongation.
Harmonizing Semantic Web Services and Mashups Using WMSL

This paper harmonizes semantic web services and mashups by leveraging semantics in Schemas, and by generating aligned ontologies from mappings between schemas. Hence, we propose to encode the import of schemas and their mappings in HTML, which when combined with JavaScript libraries enable a web user to write mashups while hiding coding complexities and promoting reuse of schemas. These Web pages yield a Web of structured data similar to the web of unstructured text of today.
Discovery of novel transcription factor binding sites by statistical overrepresentation.

Understanding the complex and varied mechanisms that regulate gene expression is an important and challenging problem. A fundamental sub-problem is to identify DNA binding sites for unknown regulatory factors, given a collection of genes believed to be co-regulated. We discuss a computational method that identifies good candidates for such binding sites. Unlike local search techniques such as expectation maximization and Gibbs samplers that may not reach a global optimum, the method discussed enumerates all motifs in the search space, and is guaranteed to produce the motifs with greatest z-scores. We discuss the results of validation experiments in which this algorithm was used to identify candidate binding sites in several well studied regulons of Saccharomyces cerevisiae, where the most prominent transcription factor binding sites are largely known. We then discuss the results on gene families in the functional and mutant phenotype catalogs of S.cerevisiae, where the algorithm suggests many promising novel transcription factor binding sites. The program is available at http://bio.cs. washington.edu/software.html.
Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting.

OBJECTIVE Diabetes mellitus is a risk factor for death after coronary artery bypass grafting. Its relative risk may be related to the level of perioperative hyperglycemia. We hypothesized that strict glucose control with a continuous insulin infusion in the perioperative period would reduce hospital mortality. METHODS All patients with diabetes undergoing coronary artery bypass grafting (n = 3554) were treated aggressively with either subcutaneous insulin (1987-1991) or with continuous insulin infusion (1992-2001) for hyperglycemia. Predicted and observed hospital mortalities were compared with both internal and external (Society of Thoracic Surgeons 1996) multivariable risk models. RESULTS Observed mortality with continuous insulin infusion (2.5%, n = 65/2612) was significantly lower than with subcutaneous insulin (5.3%, n = 50/942, P <.0001). Likewise, glucose control was significantly better with continuous insulin infusion (177 +/- 30 mg/dL vs 213 +/- 41 mg/dL, P <.0001). For internal comparison, multivariable analysis showed that continuous insulin infusion was independently protective against death (odds ratio 0.43, P =.001). Conversely, cardiogenic shock, renal failure, reoperation, nonelective operative status, older age, concomitant peripheral or cerebral vascular disease, decreasing ejection fraction, unstable angina, and history of atrial fibrillation increased the risk of death. For external comparison, observed mortality with continuous insulin infusion was significantly less than that predicted by the model (observed/expected ratio 0.63, P <.001). Multivariable analysis revealed that continuous insulin infusion added an independently protective effect against death (odds ratio 0.50, P =.005) to the constellation of risk factors in the Society of Thoracic Surgeons risk model. CONCLUSION Continuous insulin infusion eliminates the incremental increase in in-hospital mortality after coronary artery bypass grafting associated with diabetes. The protective effect of continuous insulin infusion may stem from the effective metabolic use of excess glucose to favorably alter pathways of myocardial adenosine triphosphate production. Continuous insulin infusion should become the standard of care for glycometabolic control in patients with diabetes undergoing coronary artery bypass grafting.
Smart grid cyber security: Challenges and solutions

Cyber security in smart grid systems is becoming a major concern throughout the grid communication networks and software platforms that operate and manage the entire grid. The smart grid networks characteristics such as heterogeneity, delay constraints, bandwidth, scalability, and others make it challenging to deploy uniform security approaches all over the networks segments. Therefore, more research is required to develop standards and techniques that meet the smart grid network requirements at a low cost. In this paper, we discuss some of the existing cyber security challenges in smart grid networks, highlight some of the latest solutions, and recommend a new security conceptual model based on the Internet of Things paradigm.
When a partner has a sexual problem: gendered implications for psychological well-being in later life.

OBJECTIVES Guided by symbolic interactionism, we examined (a) whether the psychological well-being of older adults might be threatened if they feel bothered by an intimate partner's sexual unresponsiveness and (b) whether such sexual unresponsiveness of a partner might be compensated by perceived supportiveness of significant others. We explored these questions separately by gender, anticipating that sexual unresponsiveness might affect men and women differently and that support from a partner might be more important for men and support from others more important for women. METHOD Using data from 1,346 participants in the National Social Life, Health, and Aging Project, we conducted multiple group regression analysis and estimated models separately but simultaneously for women and men. RESULTS Although feeling bothered by the sexual unresponsiveness of an intimate partner was significantly associated with both women's and men's depressive symptoms, the moderating effect of the partner's supportiveness was significant only for women. DISCUSSION The results suggest that gender is a key dimension for understanding the relations among negative feelings about sexual relationships, socioemotional support from significant others, and psychological well-being in older age.
Probing charge-symmetry-violating quark distributions in semi-inclusive leptoproduction of hadrons.

Recent experiments by the HERMES group at HERA are measuring semi-inclusive electroproduction of pions from deuterium. We point out that by comparing the production of $\pi^+$ and $\pi^-$ from an isoscalar target, it is possible, in principle, to measure charge symmetry violation in the valence quark distributions of the nucleons. It is also possible in the same experiments to obtain an independent measurement of the quark fragmentation functions. We review the information which can be deduced from such experiments and show the ``signature'' for charge symmetry violation in such experiments. Finally, we predict the magnitude of the charge symmetry violation, from both the valence quark distributions and the pion fragmentation function, which might be expected in these experiments.
Mir-290–295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects

Mir-290 through mir-295 (mir-290–295) is a mammalian-specific microRNA (miRNA) cluster that, in mice, is expressed specifically in early embryos and embryonic germ cells. Here, we show that mir-290–295 plays important roles in embryonic development as indicated by the partially penetrant lethality of mutant embryos. In addition, we show that in surviving mir-290–295-deficient embryos, female but not male fertility is compromised. This impairment in fertility arises from a defect in migrating primordial germ cells and occurs equally in male and female mutant animals. Male mir-290–295−/− mice, due to the extended proliferative lifespan of their germ cells, are able to recover from this initial germ cell loss and are fertile. Female mir-290–295−/− mice are unable to recover and are sterile, due to premature ovarian failure.
Assessing Business Benefits from ERP Systems: An Improved ERP Benefits Framework

Thi s pape r report s on th e busines s benefits achieve d fro m ER P system s in fou r Australia n manufacturin g organizations . Th e busines s benefits resultin g fro m ER P us e in eac h organizatio n wer e assesse d usin g th e Shan g an d Seddo n (2000 ) ER P busines s benefits framework . In additio n to confirming th e existin g benefit dimension s an d categorie s of th e ER P benefits framework , th e stud y identi fi ed ne w benefit categorie s an d resulte d in an amende d an d improve d ER P benefits framework. The findings also provide some guidance on using the f ramework.
A Fast Feature Selection Model for Online Handwriting Symbol Recognition

Many feature selection models have been proposed for online handwriting recognition. However, most of them require expensive computational overhead, or inaccurately find an improper feature set which leads to unacceptable recognition rates. This paper presents a new efficient feature selection model for handwriting symbol recognition by using an improved sequential floating search method coupled with a hybrid classifier, which is obtained by combining hidden Markov models with multilayer forward network. The effectiveness of proposed method is verified by comprehensive experiments based on UNIPEN database
Eye Tracking : The Enhanced Restricted Focus Viewer

This paper discusses the design and implementation of a unique software tool, the enhanced restricted focus viewer (ERFV), for tracking the visual attention of users in hyperlinked environments such as web sites. The software collects data such as mouse clicks along with the path of the user’s visual attention as they browse a site. Unlike traditional eye-tracking procedures, the ERFV requires no hardware other than a personal computer. In addition to cost and time savings, the ERFV also allows the administration of usability testing to groups of subjects simultaneously. The benefits of the ERFV are demonstrated through an experiment that evaluated the usability of two web sites that were equivalent in content but differed in terms of design.
Shifting Urban Margins: Accessing Unequal Spaces of Ageing and Care in Zanzibar and Muscat

ABSTRACT Older people constitute a growing proportion of the urban population and are encountered in all kinds of spaces and neighbourhoods across cities. This article argues that urban seniority and elderly care are a fruitful, new lens to study how inhabitants on the social margins create urban space and social cohesion. This article draws on ethnographic research in the cities of Zanzibar, Tanzania, and Muscat, the capital of Oman. Many older inhabitants of cities experience frailty, serious health problems, or even disabilities and are no longer able to work or make a living, which pushes them towards the social margins. The ethnographic examples and reflections in this article illustrate, first, how cities can be investigated from the perspective of social and spatial marginality. Second, they show how urban dwellers’ social positions can shift between the margins and centres of an urban society depending on their health and access to unequal spaces of ageing and care. And third, the paper analyses how some elders respond to marginality by taking up transnational and cosmopolitan agency.
The Need for Scaffolding Parent Support in an Urban School.

The efforts of an urban middle school to involve parents in the functioning of the school by employing two parent representatives in an on-site parent center were studied. The school demonstrated its commitment to parent involvement by setting aside a classroom as a parent center and staffing it with two parent representatives, one African American and one Latina. Field notes from parent meetings and interviews with seven parents, the two parent representatives, four administrators, and the parenting class teacher also provided information about the program. Some rewarding interactions did occur between parents and educators at this school, but they were limited by a variety of factors and actually involved relatively few parents. The seeds for democratic participation were planted by the diversity of the participating parents, the inclusive style of the parenting class, and the exposure of parents to the sociocultural knowledge of schooling that was transmitted in parent meetings. Overall, however, parents were not supported in gaining participation skills or opportunities to organize their own efforts. Data seem to reveal clearly that parental involvement in urban communities needs scaffolded support. Participation skills should be modeled for parents by peers who engage them in horizontal relations that allow them to learn without fear of being silenced, alienated, or embarrassed. (Contains 30 references.) (SLD) ******************************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. ******************************************************************************** THE NEED FOR SCAFFOLDING PARENT SUPPORT IN AN URBAN SCHOOL
FEROM (Feature extraction and refinement) using genetic algorithm

It is an area of text classification which continues gives contribution in research field and it analyse and classify the user generated data like reviews, blogs and comments etc. In opinion mining customer reviews generally contain the product opinions of many customers expressed in various forms consisting natural sentences. A common phenomenon in natural sentence-based customer reviews is that people generally do not express their opinions in a simple way such as "This Smartphone is good", but present them using features of the product such as "the battery life of this Smartphone is too short". The main purpose of this paper is to search for opinions about features of a target product from a collection of customer review data. Genetic algorithm analyses the opinion sentences and determines the orientations of the opinions also provide an exact summary to the user. This algorithm is used to categorize the user opinions into positive, negative and neutral classes and the categorization of text is called polarity of text.
Design and analysis of a low-power highly linear mixer

This paper presents the analysis and design of a low power and highly linear mixer topology based on the differential derivative superposition method. The analysis focuses on both nonlinearity and noise performance. The linearisation mechanism is investigated in terms of Taylor series and Volterra series. A prototype mixer has been designed and is to be implemented in 0.18 µ m CMOS technology. Simulation shows this mixer achieves 19.7dBm IIP3 with 1.1dB power gain, 13.6dB noise figure at 2.4GHz and only 3.8mW power consumption. This performance is competitive with already reported mixers.
MARSS: A full system simulator for multicore x86 CPUs

We present MARSS, an open source, fast, full system simulation tool built on QEMU to support cycle-accurate simulation of superscalar homogeneous and heterogeneous multicore x86 processors. MARSS includes detailed models of coherent caches, interconnections, chipsets, memory and IO devices. MARSS simulates the execution of all software components in the system, including unmodified binaries of applications, OS and libraries.
Making sense of organizational change : a storytelling approach

This thesis aims to analyse organizational change, focusing on the meanings attributed by participants in planned and unplanned processes of organizational change, in a large, UK hospitality company. Framed within the narrative meta-paradigm, this research employs a qualitative, interpretive, social-constructionist perspective, and considers change in organizations as constituted by alterations in people’s understandings, encoded in narratives, and shared in conversations. The thesis draws on prior publications in the fields of narrative and organizational change, including the sensemaking, power and identity literatures. Data was co-created through sixty-six semi-structured interviews in a single, multi-site case study, augmented by informal observations and assessment of written materials. The research account tells the stories of: organizational change; the responses from members to change; and the shifts in power, control and autonomy. These narratives of change were prepared through an interpretive analysis of the interview transcripts, and the study provides a reflexive commentary on the research, through vignettes of the researcher’s experience. In the discussion, three readings interpret the case study from a narrative, an organizational change and an autoethnographic perspective. The primary contribution of the thesis is empirical, providing an in-depth case study that describes a complex organizational landscape, at two luxury hotels, into which a managerial initiative, Shine, was launched, and addresses the limited presence of narrative case studies on change. Through the application of existing theory to this empirical resource, the thesis contributes to understandings of sensemaking, power and identity during continuous change. The study argues for the significance of reflexivity in storytelling research, and the need for practitioners to embrace the socially constructed nature of ‘realities’ in working with organizational change. More generally, the thesis has demonstrated the value of a storytelling approach to understanding the complexities of organizational change, while identifying limitations to plurivocal storytelling as a research method.
Embedded B-spline reconstruction in the volume rendering

This. paper deals with the reconstruction problem in visualization. The representation of the object is based on the volumetric data. Volumetric data is sampled on a regular grid. The surface of the object is implicitly defined as a zero value of the volumetric function. In the volume rendering procedure, intersection of the cast ray with the object is required. Trilinear interpolation is usually used for the reconstruction. In this paper we propose interpolation B-spline embedded directly into the rendering procedure. Different artifacts may appear due to the reconstruction in the rendering procedure. If the quality of the rendered object is of the crucial importance we have to pay attention on the reconstruction in the rendering procedure.
Drosophila SNAP-29 Is an Essential SNARE That Binds Multiple Proteins Involved in Membrane Traffic

Each membrane fusion event along the secretory and endocytic pathways requires a specific set of SNAREs to assemble into a 4-helical coiled-coil, the so-called trans-SNARE complex. Although most SNAREs contribute one helix to the trans-SNARE complex, members of the SNAP-25 family contribute two helixes. We report the characterization of the Drosophila homologue of SNAP-29 (dSNAP-29), which is expressed throughout development. Unlike the other SNAP-25 like proteins in fruit fly (i.e., dSNAP-25 and dSNAP-24), which form SDS-resistant SNARE complexes with their cognate SNAREs, dSNAP-29 does not participate in any SDS-resistant complexes, despite its interaction with dsyntaxin1 and dsyntaxin16 in vitro. Immunofluorescence studies indicated that dSNAP-29 is distributed in various tissues, locating in small intracellular puncta and on the plasma membrane, where it associates with EH domain-containing proteins implicated in the endocytic pathway. Overexpression and RNAi studies suggested that dSNAP-29 mediates an essential process in Drosophila development.
Beyond document similarity: understanding value-based search and browsing technologies

In the face of small, one or two word queries, high volumes of diverse documents on the Web are overwhelming search and ranking technologies that are based on document similarity measures. The increase of multimedia data within documents sharply exacerbates the shortcomings of these approaches. Recently, research prototypes and commercial experiments have added techniques that augment similarity-based search and ranking. These techniques rely on judgments about the 'value' of documents. Judgments are obtained directly from users, are derived by conjecture based on observations of user behavior, or are surmised from analyses of documents and collections. All these systems have been pursued independently, and no common understanding of the underlying processes has been presented. We survey existing value-based approaches, develop a reference architecture that helps compare the approaches, and categorize the constituent algorithms. We explain the options for collecting value metadata, and for using that metadata to improve search, ranking of results, and the enhancement of information browsing. Based on our survey and analysis, we then point to several open problems.
Discrete annuities using truncate stochastic interest rates: the case of a Vasicek and Ho-Lee model

A subject often recurring in the recent financial and actuarial research, is the investigation of present value functions with stochastic interest rates. Only in the case of uncomplicated payment streams and rather basic interest rate models, an exact analytical result for the distribution function is available. In the present contribution, we introduce the concept of truncate stochastic interest rates, useful to adapt general stochastic models to specific financial requirements, and we show how to obtain in that case analytical results for bounds for the present value. We employ our method in extension for the Ho-Lee model and the Vasicek model. We illustrate the accuracy of the approximations graphically, and we use the bounds to estimate the Value-at-Risk.