Miracle-dz/UniFAR-FTUs huggingface dataset:
Event Driving Based Alarm Correlation Approach by Using Petri Net

According to practical requirement, this paper puts forward an alarm event correlation approach basing on event driving, which considers the temporal relationship between events, and establishes several Petri net models. The experiment results show that, the approach basing on event driving to select time window can implement the alarm event correlation correctively and effectively for complex network. So the accuracy and efficiency of alarm is improved.
Software Development as Activities Creating and Utilizing Socio-Technical Information Spaces

Software development is a process of gathering and creating information; it requires programmers to uncover the various parts that are related to their current task. We propose to conceptualize a software system being developed as a socio-technical information space that has multiple layers of links that relate different units of information resources that include code, documents and programmers. This conceptualization can lead to the creation of better tools that support the exploration of various latent relations to identify relevant resources that cannot be easily achieved by technical or social analysis alone.
Regulation of Sialidase Production in Clostridium perfringens by the Orphan Sensor Histidine Kinase ReeS

Clostridium perfringens is ubiquitous in nature and is often found as a commensal of the human and animal gastrointestinal tract. It is the primary etiological agent of clostridial myonecrosis, or gas gangrene, a serious infection that results in extensive tissue necrosis due to the action of one or more potent extracellular toxins. α-toxin and perfringolysin O are the major extracellular toxins involved in the pathogenesis of gas gangrene, but histotoxic strains of C. perfringens, such as strain 13, also produce many degradative enzymes such as collagenases, hyaluronidases, sialidases and the cysteine protease, α-clostripain. The production of many of these toxins is regulated either directly or indirectly by the global VirSR two-component signal transduction system. By isolating a chromosomal mutant and carrying out microarray analysis we have identified an orphan sensor histidine kinase, which we have named ReeS (regulator of extracellular enzymes sensor). Expression of the sialidase genes nanI and nanJ was down-regulated in a reeS mutant. Since complementation with the wild-type reeS gene restored nanI and nanJ expression to wild-type levels, as shown by quantitative reverse transcription-PCR and sialidase assays we concluded that ReeS positively regulates the expression of these sialidase genes. However, mutation of the reeS gene had no significant effect on virulence in the mouse myonecrosis model. Sialidase production in C. perfringens has been previously shown to be regulated by both the VirSR system and RevR. In this report, we have analyzed a previously unknown sensor histidine kinase, ReeS, and have shown that it also is involved in controlling the expression of sialidase genes, adding further complexity to the regulatory network that controls sialidase production in C. perfringens.
Aspartyl-(asparaginyl) β-Hydroxylase, Hypoxia-Inducible Factor-1α and Notch Cross-Talk in Regulating Neuronal Motility

Aspartyl-(Asparaginyl)-β-Hydroxylase (AAH ) promotes cell motility by hydroxylating Notch. Insulin and insulin-like growth factor, type 1 (IGF-I) stimulate AAH through Erk MAP K and phosphoinositol-3-kinase-Akt (PI3K-Akt). However, hypoxia/oxidative stress may also regulate AAH . Hypoxia-inducible factor-1alpha (HIF-1α) regulates cell migration, signals through Notch, and is regulated by hypoxia/oxidative stress, insulin/IGF signaling and factor inhibiting HIF-1α (FIH) hydroxylation. To examine cross-talk between HIF-1α and AAH , we measured AAH , Notch-1, Jagged-1, FIH, HIF-1α, HIF-1β and the hairy and enhancer of split 1 (HE S-1) transcription factor expression and directional motility in primitive neuroectodermal tumor 2 (PNET2) human neuronal cells that were exposed to H2O2 or transfected with short interfering RNA duplexes (siRNA) targeting AAH , Notch-1 or HIF-1α. We found that: (1) AAH , HIF-1α and neuronal migration were stimulated by H2O2; (2) si-HIF-1α reduced AAH expression and cell motility; (3) si-AAH inhibited Notch and cell migration, but not HIF-1α and (4) si-Notch-1 increased FIH and inhibited HIF-1α. These findings suggest that AAH and HIF-1α crosstalk within a hydroxylation-regulated signaling pathway that may be transiently driven by oxidative stress and chronically regulated by insulin/IGF signaling.
Rv2607 from Mycobacterium tuberculosis Is a Pyridoxine 5′-Phosphate Oxidase with Unusual Substrate Specificity

Despite intensive effort, the majority of the annotated Mycobacterium tuberculosis genome consists of genes encoding proteins of unknown or poorly understood function. For example, there are seven conserved hypothetical proteins annotated as homologs of pyridoxine 5′-phosphate oxidase (PNPOx), an enzyme that oxidizes pyridoxine 5′-phosphate (PNP) or pyridoxamine 5′-phosphate (PMP) to form pyridoxal 5′-phosphate (PLP). We have characterized the function of Rv2607 from Mycobacterium tuberculosis H37Rv and shown that it encodes a PNPOx that oxidizes PNP to PLP. The kcat and KM for this reaction were 0.01 s−1 and 360 µM, respectively. Unlike many PNPOx enzymes, Rv2607 does not recognize PMP as a substrate.
Investigating the Role of Working Memory Components in Mathematical Cognition in Children: A Scoping Review

Mathematics has been long known to be a complicated subject, requiring an advanced set of skills. Each skill learned in mathematics requires different level of effort and goes through a different path of processing when working memory is utilized. Being a leading indicator of children’s academic achievement, mathematical cognition is of vital importance and is monitored from a young age, where low performance could be a sign of a learning disability that needs to be addressed. A scoping review of literature was conducted to investigate the fortifying evidence on the importance of working memory in children’s mathematical performance, and present the common measures for which future research in this field would need to account. One of the main findings of this research is the strong contribution of working memory to problem solving, whether it is a single- or multi-digit arithmetic in consideration. Verbal working memory will have greater contribution for orally presented problems in contrast to written ones that would interact with visual-spatial sketchpad. A number of measures were agreed on to be good contributors for working memory performance, however some limitations apply on the modeling of working memory which was found to be alleviating some implications; at the same time, providing rich soil for cultivating new research.
Correlated mutations and residue contacts in proteins

The maintenance of protein function and structure constrains the evolution of amino acid sequences. This fact can be exploited to interpret correlated mutations observed in a sequence family as an indication of probable physical contact in three dimensions. Here we present a simple and general method to analyze correlations in mutational behavior between different positions in a multiple sequence alignment. We then use these correlations to predict contact maps for each of 11 protein families and compare the result with the contacts determined by crystallography. For the most strongly correlated residue pairs predicted to be in contact, the prediction accuracy ranges from 37 to 68% and the improvement ratio relative to a random prediction from 1.4 to 5.1. Predicted contact maps can be used as input for the calculation of protein tertiary structure, either from sequence information alone or in combination with experimental information. © 1994 John Wiley & Sons, Inc.
Preferencias, renuncias y oportunidades en la práctica de ocio de los jóvenes vulnerables

Se presentan los resultados de una investigacion realizada entre 2013 y 2016 que tiende a indagar sobre las preferencias de la practica de actividades de ocio de los jove- nes espanoles mas vulnerables y los motivos de renuncia a su entretenimiento; asimismo, se pretende explorar la relacion entre la renuncia a la practica de ocio de esta poblacion y su sexo. Por ultimo, se trata de analizar el efecto de la renuncia a la practica del ocio sobre la importancia en las capacidades formativas, entendidas como una oportunidad para la trayec- toria de vida de estos jovenes. Para ello, se realizo un estudio cuantitativo de tipo descriptivo en el que se aplico un cuestionario elaborado ad hoc a una muestra de 2.694 participantes. De ellos 783 fueron identificados como jovenes vulnerables. Como resultado, las practicas de ocio preferentes de los jovenes vulnerables coinciden con las del resto de la poblacion juvenil espanola, destacando las actividades deportivas, las relacionadas con las TIC y con la musica. Se confirman, los planteamientos sobre la pobreza del ocio de estos jovenes, que renuncian frecuentemente a sus practicas de ocio preferidas por falta de recursos y por motivos rela- cionales, especialmente las mujeres. Ademas, se hallan diferencias en funcion de renunciar o no a alguna practica de ocio en relacion a la importancia que los jovenes vulnerables otorgan a las capacidades de creatividad e innovacion y en la de gestion de conflictos. Los jovenes que renuncian a las actividades de ocio son los que mas valoran estas capacidades. Estos resultados facilitan orientaciones precisas para una intervencion socioeducativa mas eficaz con este colectivo.
A multi band mini printed omni directional antenna with v-shaped for RFID applications

This paper presents a mini multi-band printed omni- directional antenna with v-shaped structure for radio frequency identiflcation (RFID) applications. The proposed multi-band antenna is developed from the initial v-shaped design which is only capable of working as a single-band antenna. By deploying a concept of dipole antenna to an initial design, the proposed antenna is accomplished to operate with two difierent modes of RFID system which are passive and active modes at frequencies of 915MHz and 2.45GHz respectively. The passive RFID tag is invented when a chip of Ultra High Frequency (UHF) is integrated with a proposed multi-band antenna. This passive tag, which is able to radiate with the measured signal strength, shows that the reading ranges are boosted almost two times compared to the conventional inlay antenna. The maximum reading range of passive RFID tag with inlay antenna is 5m, though a reading range up to 10m is achievable through the deployment of the proposed antenna at a measurement fleld. Implicitly, the measurements carried out on the antenna are in good agreement with the simulated values. Moreover, the size of the mobile passive RFID tag has been substantially as 100mm £ 70mm, even though the antenna is fabricated with an inexpensive FR-4 substrate material. With the reasonable gain, coupled with cheaper material and smaller size, the proposed antenna
SEMEX: Mining for Personal Information Integration

Personal information management is one of the key applications of the semantic web. Whereas today’s devices store data according to applications, ideal personal information management system should treat all data as a set of meaningful objects and associations between the objects. To ensure extensibility, a personal information management sys-tem should automatically incorporate associations generated in multiple ways: mining speci(cid:12)c personal data sources, or integrating with external data. As a (cid:12)rst step in this direction, we describe the Semex system that provides a logical and integrated view of one’s personal information.
Effectiveness of Automated Insulin Management Features of the MiniMed® 640G Sensor-Augmented Insulin Pump

Abstract Background: Automated insulin management features of the MiniMed® 640G sensor-augmented pump system include suspension in response to predicted low sensor glucose (SG) values (“suspend before low”), suspension in response to existing low SG values (“suspend on low”), and automatic restarting of basal insulin delivery upon SG recovery. The effectiveness of these features was evaluated using CareLink® software data. Methods: Anonymized data from MiniMed 640G system users (n = 4818), MiniMed 530G system users (n = 39,219), and MiniMed Paradigm® Veo™ system users (n = 43,193) who voluntarily uploaded pump and sensor data were retrospectively analyzed. Comparisons were made between days in which system features were enabled at any time and those in which they were not. Comparisons were also made between pump suspension events for which insulin delivery was automatically or manually resumed and between glycemic parameters of users who switched from the MiniMed Paradigm Veo system to the MiniMed 640G system. Results: Days in which the MiniMed 640G “suspend before low” feature was enabled had lower percentages of SG readings ≤70 mg/dL (3.9 mmol/L) or ≥240 mg/dL (13.3 mmol/L) than days when it was not enabled (P < 0.001 for each). Users who switched from the MiniMed Paradigm Veo system to the MiniMed 640G system had fewer excursions below ≤70 mg/dL (P < 0.001) and ≥240 mg/dL (P < 0.001). SG values following automatically resumed pump suspension events recovered more rapidly and had a more stabilized endpoint than following manually resumed events. Conclusions: Automated insulin management features of the MiniMed 640G system can reduce the frequency of both high and low SG values and help stabilize SG after resumption of insulin delivery.
Meta-analyses in sales research

Meta-analytic inquiries enable researchers to synthesize empirical findings obtained over the evolution of a topic area and identify boundary conditions affecting the associations of key variables. Sales researchers can employ meta-analytic techniques to amalgamate empirical work conducted in a given topic area, and several sales researchers have effectively used meta-analyses to advance our understanding of the field. This article provides an exposition of this research design by analyzing its application in sales research. The authors review the meta-analytic studies in sales research and advance key considerations in topical foci, article selection, data coding and evaluation, and analytic approaches. An empirical example is provided to illustrate the power of meta-analysis in substantiating or refuting findings that diverge from accumulated insight in sales research. Results provide support for a positive effort–job satisfaction association in contrast to findings evidencing a negative association between these variables. A second empirical example is used to evaluate the nomological and discriminant validity of two related constructs: job involvement and organizational commitment. Results suggest that these two constructs may be empirically redundant. The authors also provide guidance for the future in regard to new substantive research areas, construct assessment, and additional types of meta-analytic approaches.
Studies of volcanoes of Alaska by satellite radar interferometry

Interferometric synthetic aperture radar (InSAR) has provided a new imaging geodesy technique to measure the deformation of volcanoes at tens-of-meter horizontal resolution with centimeter to subcentimeter vertical precision. The two-dimensional surface deformation data enables the construction of detailed numerical models allowing the study of magmatic and tectonic processes beneath volcanoes. This paper summarizes our recent InSAR studies over the AlaskaAleutian volcanoes, which include New Trident, Okmok, Akutan, Augustine, Shishaldin, and Westdahl volcanoes. The first InSAR surface deformation over the Alaska volcanoes was applied to New Trident. Preliminary InSAR study suggested that New Trident volcano experienced several centimeters inflation from 1993 to 1995. Using the InSAR technique, we studied the 1997 eruption of Okmok. We have measured ~1.4 m deflation during the eruption, ~20 cm pre-eruptive inflation during 1992 to 1995, and >10 cm post-eruptive inflation within a year after the eruption, and modeled the deformations using Mogi sources. We imaged the ground surface deformation associated with the 1996 seismic crisis over Akutan volcano. Although seismic swarm did not result in an eruption, we found that the western part of the volcano uplifted ~60 cm while the eastern part of the island subsided. The majority of the complex deformation field at the Akutan volcano was modeled by dike intrusion and Mogi inflation sources. Our InSAR results also indicate that the pyroclastic flows from last the last eruption have been undergoing contraction/subsidence at a rate of about 3 cm per year since 1992. InSAR measured no surface deformation before and during the 1999 eruption of Shishaldin and suggested the eruption may be a type of open system. Finally, we applied satellite radar interferometry to Westdahl volcano which erupted 1991 and has been quiet since. We discovered this volcano had inflated about 15 cm from 1993 to 1998. In summary, satellite radar interferometry can not only be used to study a volcanic eruption, but also to detect aseismic deformation at quiescent volcanoes preceding a seismic swarm; it is a useful technique to study volcanic eruptions as well as to guide scientists to better focus their monitoring efforts.
All in the family: Informal childcare and mothers' labour market participation

In the traditional models of female labour supply formal childcare is assumed to be provided by the market. This is not the case in most European countries. In this paper we estimate the causal effect of a particular kind of informal care, the one provided by grandparents, on mothers' work decisions in Italy. We deal with the endogeneity due to mothers' and grandparents' unobserved preferences by instrumenting grandparents' help. We find that having grandparents helping with childcare increases mothers' labour market participation. The effect is particularly strong for lower educated mothers of young children, in North and Centre Italy.
Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+

Abstract Aims: 1-Methyl-4-phenyl-tetrahydropyridine (MPTP) is among the most widely used neurotoxins for inducing experimental parkinsonism. MPTP causes parkinsonian symptoms in mice, primates, and humans by killing a subpopulation of dopaminergic neurons. Extrapolations of data obtained using MPTP-based parkinsonism models to human disease are common; however, the precise mechanism by which MPTP is converted into its active neurotoxic metabolite, 1-methyl-4-phenyl-pyridinium (MPP+), has not been fully elucidated. In this study, we aimed to address two unanswered questions related to MPTP toxicology: (1) Why are MPTP-converting astrocytes largely spared from toxicity? (2) How does MPP+ reach the extracellular space? Results: In MPTP-treated astrocytes, we discovered that the membrane-impermeable MPP+, which is generally assumed to be formed inside astrocytes, is almost exclusively detected outside of these cells. Instead of a transporter-mediated export, we found that the intermediate, 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+), and/or its uncharged conjugate base passively diffused across cell membranes and that MPP+ was formed predominately by the extracellular oxidation of MPDP+ into MPP+. This nonenzymatic extracellular conversion of MPDP+ was promoted by O2, a more alkaline pH, and dopamine autoxidation products. Innovation and Conclusion: Our data indicate that MPTP metabolism is compartmentalized between intracellular and extracellular environments, explain the absence of toxicity in MPTP-converting astrocytes, and provide a rationale for the preferential formation of MPP+ in the extracellular space. The mechanism of transporter-independent extracellular MPP+ formation described here indicates that extracellular genesis of MPP+ from MPDP is a necessary prerequisite for the selective uptake of this toxin by catecholaminergic neurons. Antioxid. Redox Signal. 23, 1001–1016.
Title: Internet-based Carbon Tools for Behaviour Change Author: Catherine Bottrill

Internet-based carbon calculators have the potential to be powerful tools to help people understand their personal energy use (mainly derived from fossil fuels) and for motivating actions to reduce carbon emissions. This paper assesses thirty carbon calculators, based on their accuracy and effectiveness and shows that in most cases this environmental learning tool is falling short of i) giving people the ability to accurately monitor their energy use, ii) providing them with meaningful feedback and guidance for altering their energy use, iii) connecting them with other users also going through the same learning process of saving energy and conserving carbon. Suggestions for the development of the “next generation” of carbon calculators are then provided, aiming at tackling the short-comings of the existing carbon calculators. A number of tools, presently in beta development, are included in this review and are good indicators of some of the exciting directions these tools could go. The Environmental Change Institute also has developed a beta tool, IMeasure, for measuring, benchmarking and targeting personal energy use reductions.
Tactile rendering of 3D features on touch surfaces

We present a tactile-rendering algorithm for simulating 3D geometric features, such as bumps, on touch screen surfaces. This is achieved by modulating friction forces between the user's finger and the touch screen, instead of physically moving the touch surface. We proposed that the percept of a 3D bump is created when local gradients of the rendered virtual surface are mapped to lateral friction forces. To validate this approach, we first establish a psychophysical model that relates the perceived friction force to the controlled voltage applied to the tactile feedback device. We then use this model to demonstrate that participants are three times more likely to prefer gradient force profiles than other commonly used rendering profiles. Finally, we present a generalized algorithm and conclude the paper with a set of applications using our tactile rendering technology.
Face Recognition under Varying Illumination Based on Local Binary Patterns with Circle Threshold

To solve the challenging problem of face recognition under varying illumination conditions, we propose in this paper a novel LBP operator which we refer to as Local Binary Patterns with Circle Threshold (CT-LBP) operator. The CT-LBP operator can keep more discriminating information than the original LBP operator without losing the simplicity and effectivity of the original LBP operator. Extensive PCA-based experiments conducted on the Yale Face Database B demonstrate that the proposed method has been of general recognition rate of 98.13% on Yale Face Database B against extreme ighting conditions and outperforms the ones based on the original LBP operator.