Miracle-dz/UniFAR-FTUs huggingface dataset:
Levomilnacipran: A New Serotonin-Norepinephrine Reuptake Inhibitor for the Treatment of Major Depressive Disorder.

OBJECTIVE To provide a clinical overview of the antidepressant levomilnacipran. DATA SOURCES Articles were identified by searching the MEDLINE, PubMed, Cochrane Library, and Clinicaltrials.gov databases through March 2014 using the keyword levomilnacipran. The manufacturer provided additional information from unpublished phase II and phase III trials. STUDY SELECTION AND DATA EXTRACTION Any clinical trial conducted for at least 3 weeks and published in the English language was selected for review. Additional documentation, including the product dossier, package insert, pharmacokinetic studies, and poster presentations supplied by the manufacturer, was also evaluated. DATA SYNTHESIS Levomilnacipran is the more potent enantiomer of milnacipran. It is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), dosed from 20 to 120 mg daily for the treatment of major depressive disorder (MDD). Efficacy and tolerability were established during 3 phase III randomized, double-blind placebo-controlled trials finding levomilnacipran to be significantly more efficacious than placebo in reduction of Montgomery-Åsberg Depression Rating Scale scores. It is not known whether this agent is more efficacious than other antidepressants because direct comparison studies have not been conducted as of the time of this review. CONCLUSIONS Levomilnacipran demonstrates efficacy and tolerability for short-term treatment of MDD in adults. Available evidence does not strongly indicate that there is a specific subpopulation of patients who would benefit from levomilnacipran over currently available SNRIs. Full characterization of the agent's place in therapy alongside multiple other agents with similar mechanisms and efficacy requires trials with longer duration and active comparators.
The nosology of Richieri‐Costa/Guion‐Almeida syndrome(s)

Richieri‐Costa/Guion‐Almeida syndrome type 1 (RCGAS1) is a rare MR/MCA syndrome comprising developmental and growth delay, microcephaly, prominent supraorbital ridges, asymmetric ptosis and eyebrows, esotropia, nystagmus, eye colobomas, and cleft lip/palate. It was originally described in three brothers and an additional sporadic male. The same authors also described a further family with a partially overlapping condition in two sisters (Richieri‐Costa/Guion‐Almeida syndrome type 2, RCGAS2). We report on a sporadic, mentally retarded patient strongly resembling those of the original report of RCGAS1, but lacking some manifestations such as short stature and, possibly, some ocular changes. Results of 200 kb CGH‐array study were normal. By comparing the present and previously reported patients with RCGAS1 and 2, we tried to contribute to syndrome delineation and to separate them from conditions with similar facial anomalies. © 2010 Wiley‐Liss, Inc.
A Switched-capacitor Neural Preamplifier with an Adjustable Pass-band for Fast Recovery following Stimulation

For extracellular recordings from neurons, it is desirable to use the same electrode for stimulation as well as for recording. Since neural preamplifiers usually exhibit high-pass filtering at frequencies as low as 0.1 Hz, the recovery from saturation is typically very slow. Consequently, following stimulation, no signal can be detected for up to several seconds. This is unacceptably slow response of the preamplifier because the majority of neurons fires action potentials within first milliseconds following stimulation. Here we propose to use a switched-capacitor preamplifier with adjustable pass-band for fast recovery from saturation caused by stimulation via the recording electrode. The idea was tested in a real preamplifier manufactured with a standard CMOS technology (0.35 mum). In control conditions, the high-pass filter was set to 100 Hz and, during stimulation, was shifted to 10 kHz. Such a shift allows the reduction of the recovery time from tens of milliseconds to sub-millisecond range
Downregulation of Vascular Angiotensin II Type 1 Receptor by Thyroid Hormone

Abstract—Thyroid hormone has a broad effect on cardiovascular system. 3,3′,5-triiodo-l-thyronine (T3), a biologically active form of thyroid hormone, increases cardiac contractility. T3 causes arterial relaxation and reduction of systemic vascular resistance, resulting in an increase in cardiac output. However, the molecular mechanisms of vascular relaxation by T3 are incompletely characterized. We studied the effect of T3 on the angiotensin (Ang) II type 1 receptor (AT1R) expression in vascular smooth muscle cells. T3 dose-dependently decreased expression levels of AT1R mRNA, with a peak at 6 hours of stimulation. Binding assay using [125I]Sar1-Ile8-Ang II revealed that AT1R number was decreased by stimulation with T3 without changing the affinity to Ang II. T3 reduced calcium response of vascular smooth muscle cells to Ang II by 26%. AT1R promoter activity measured by luciferase assay was reduced by 50% after 9 hours of T3 administration. mRNA stability was also decreased by T3. Real-time quantitative reverse transcription–polymerase chain reaction and Western blot analysis revealed that AT1R mRNA and protein were downregulated in the aorta of T3-treated rats. These results suggest that T3 downregulates AT1R expression both at transcriptional and posttranscriptional levels, and attenuates biological function of Ang II. Our results suggest that downregulation of AT1R gene expression may play an important role for T3-induced vascular relaxation.
Physical and Functional Interaction between Elongator and the Chromatin-associated Kti12 Protein*

Cells lacking KTI12 or Elongator (ELP) genes are insensitive to the toxin zymocin and also share more general phenotypes. Moreover, data from low stringency immunoprecipitation experiments suggest that Elongator and Kti12 may interact. However, the precise relationship between these factors has not been determined. Here we use a variety of approaches to investigate the possibility that Elongator and Kti12 functionally overlap. Native Kti12 purified to virtual homogeneity under stringent conditions is a single polypeptide, but depletion of Kti12 from a yeast extract results in co-depletion of Elongator, indicating that these factors do interact. Indeed, biochemical evidence suggests that Elongator and Kti12 form a fragile complex under physiological salt conditions. Purified Kti12 does not affect Elongator histone acetyltransferase activity in vitro. However, a variety of genetic experiments comparing the effects of mutation in ELP3 and KTI12 alone and in combination with other transcription factor mutations clearly demonstrate a significant functional overlap between Elongator and Kti12 in vivo. Intriguingly, chromatin immunoprecipitation experiments show that Kti12 is associated with chromatin throughout the genome, even in non-transcribed regions and in the absence of Elongator. Conversely, RNA-immunoprecipitation experiments indicate that Kti12 only plays a minor role for Elongator association with active genes. Together, these experiments indicate a close physical and functional relationship between Elongator and the highly conserved Kti12 protein.
An Efficient Traffic Geographic Static-Node-Assisted Routing in VANET

The link is easy to break due to the high mobility of nodes and the constraint of road in a VANET. In this paper, we present an efficient traffic geographic routing (ETGR) with static node assistance. It includes road information collection, road weight information dissemination, the efficient traffic geographic routing and the duration estimation of the path. Each static node stores the information of other static nodes in the path for a given time. The static nodes are fixed in each intersection. The method takes static nodes as backbone nodes and vehicles as the relay nodes between two static nodes, which can survive the path for a period of time. The ETGR selects the static nodes dynamically and sequentially. The static nodes are chosen considering such parameters as the remaining distance to the destination, vehicular density, vehicular speed, etc. Route request packets forwarding between two static nodes adopts a greedy mechanism. Simulation results show performance improvement comparing with the performance of other existing routing approaches
Exploring bimanual camera control and object manipulation in 3D graphics interfaces

We explore the use of the non-dominant hand to control a virtualcamera while the dominant hand performs other tasks in a virtual 3Dscene. Two experiments and an informal study are presented whichevaluate this interaction style by comparing it to the status-quounimanual interaction. In the first experiment, we find that for atarget selection task, performance using the bimanual technique was20% faster. Experiment 2 compared performance in a more complicatedobject docking task. Performance advantages are shown, however,only after practice. Free-form 3D painting was explored in the userstudy. In both experiments and in the user study participantsstrongly preferred the bimanual technique. The results alsoindicate that user preferences concerning bimanual interaction maybe driven by factors other than simple time-motion performanceadvantages.
Python Scripting: The Return to Programming

More than 30 years ago, before the first public version of MODFLOW, programming was an essential skill for groundwater modelers. With the advent of graphical user interfaces, models could be built by clicking a series of buttons. This allowed modelers to spend more time on simulation without the need for programming skills. Unfortunately, models created with a user interface are not easily reproduced, archived, or independently verified. Modeling errors are easily made, yet difficult to find and correct. In recent years, computer programming is making a comeback in the form of scripting. A script is a piece of computer code designed to perform one or more specific tasks. A script can be written, for example, to read GIS files, build a model, run it, analyze the output, and create graphical output. Scripts are also well-suited to perform data analysis from the original measurements to the final result. As scripts are readable files, it is much easier to catch and correct errors. A script is a record of the entire modeling or data analysis process. By simply running the script you reprocess the entire model or analysis. How about that for reproducible results? The advantage of using scripts to document modeling and data analysis is recognized in many fields. For example, Baggerly and Coombes (2009) recommend the use of scripts in response to the well-published cancer research scandal at Duke University, where patients were put at risk as a consequence of errors in data analysis. The free and open-source computer language Python is ideal for writing scripts. Python has a simple yet powerful syntax and is becoming increasingly popular among hydrogeologists. There are many packages for Python to perform advanced tasks from statistical analysis of large datasets to parameter optimization and the
Socially-aware routing for publish-subscribe in delay-tolerant mobile ad hoc networks

Applications involving the dissemination of information directly relevant to humans (e.g., service advertising, news spreading, environmental alerts) often rely on publish-subscribe, in which the network delivers a published message only to the nodes whose subscribed interests match it. In principle, publish- subscribe is particularly useful in mobile environments, since it minimizes the coupling among communication parties. However, to the best of our knowledge, none of the (few) works that tackled publish-subscribe in mobile environments has yet addressed intermittently-connected human networks. Socially-related people tend to be co-located quite regularly. This characteristic can be exploited to drive forwarding decisions in the interest-based routing layer supporting the publish-subscribe network, yielding not only improved performance but also the ability to overcome high rates of mobility and long-lasting disconnections. In this paper we propose SocialCast, a routing framework for publish-subscribe that exploits predictions based on metrics of social interaction (e.g., patterns of movements among communities) to identify the best information carriers. We highlight the principles underlying our protocol, illustrate its operation, and evaluate its performance using a mobility model based on a social network validated with real human mobility traces. The evaluation shows that prediction of colocation and node mobility allow for maintaining a very high and steady event delivery with low overhead and latency, despite the variation in density, number of replicas per message or speed.
Motion field texture synthesis

A variety of animation effects such as herds and fluids contain detailed motion fields characterized by repetitive structures. Such detailed motion fields are often visually important, but tedious to specify manually or expensive to simulate computationally. Due to the repetitive nature, some of these motion fields (e.g. turbulence in fluids) could be synthesized by procedural texturing, but procedural texturing is known for its limited generality. We apply example-based texture synthesis for motion fields. Our technique is general and can take on a variety of user inputs, including captured data, manual art, and physical/procedural simulation. This data-driven approach enables artistic effects that are difficult to achieve via previous methods, such as heart shaped swirls in fluid animation. Due to the use of texture synthesis, our method is able to populate a large output field from a small input exemplar, imposing minimum user workload. Our algorithm also allows the synthesis of output motion fields not only with the same dimension as the input (e.g. 2D to 2D) but also of higher dimension, such as 3D volumetric outputs from 2D planar inputs. This cross-dimension capability supports a convenient usage scenario, i.e. the user could simply supply 2D images and our method produces a 3D motion field with similar characteristics. The motion fields produced by our method are generic, and could be combined with a variety of large-scale low-resolution motions that are easy to specify either manually or computationally but lack the repetitive structures to be characterized as textures. We apply our technique to a variety of animation phenomena, including smoke, liquid, and group motion.
Neuroengineering Original Research Article

a single FP instead of the fl uorescence resonance energy transfer (FRET) pair yielded VSFP3.1. These latest versions of the second (VSFP2s) and third (VSFP3s) generation FP voltage sensors exhibit an improved targeting to the plasma membrane, dynamic range and kinetics of voltage-dependent fl uorescent changes (Lundby et al., 2008; Mutoh et al., 2009). In spite of this initial breakthrough, development of optimized sensors with superior signal-to-noise ratio and optimized spectral properties remains imperative for in depth analysis of neuronal circuit dynamics. One of the most straightforward approaches to develop genetically encoded sensors with superior dynamic range and sensitivity is based on circularly permuted fl uorescent proteins Circular permutation of a protein consists of connecting the native amino (N-) and carboxyl (C-) termini covalently with a peptide linker and cleaving the peptide backbone at one specifi c site (Luger et al., 1989). Pioneering work of Baird et al. (1999) have demonstrated circular permutation sites within Aequorea victoria GFP variants that preserve the original folding and formation of fl uorophore. In these fl uorescent circularly permuted GFP variants, new termini are introduced into alpha helices and beta sheets. Circular permutation thus allows placing the fusion of a sensor domain in close proximity to the chromophore environment, which can lead to direct changes in the fl uorescent signal upon structural rearrangements initiated by the sensor domain. Based on this concept, several Ca 2+ sensors have been developed, the best of which show much greater fractional fl uorescent changes than FRET-based Ca 2+ probes (Nagai
Factors Affecting the Mechanical Properties of Modern Paints

It is well known that modern artists use many types of paint in their work, and they frequently experiment with products outside of those sold by art supply retailers. As a result, museums acquire paintings that are highly variable in composition. It is useful to understand trends in the mechanical properties of both artist-grade and household paints to properly care for objects containing such materials. For this study, a selection of white paints commonly used in the United Kingdom was prepared for chemical and mechanical analysis. The aim was to identify their compositions and relate this information to their respective mechanical properties. Several materials were included in the analysis: an artists' emulsion, household (matte, eggshell, silk) emulsions, an artists' alkyd, household alkyds, a traditional oil, and a water-mixable oil. Pigment and filler ingredients were identified by Fourier transform infrared (FTIR) spectroscopy, and in some cases inorganic components were verified by energy dispersive X-ray analysis (EDX). Binder resins were identified for the solvent and waterborne paints using pyrolysis gas chromatography/mass spectrometry (PyGC/MS). Mechanical properties were determined through measurements of stress-strain curves under controlled environmental conditions. Results showed a wide range of properties due to different levels of pigment and filler in the paint systems. This was especially true for the household emulsions, which are manufactured with many different pigment volume concentrations (PVC) to modify optical properties. Tensile tests were also performed on specific materials to illustrate the plasticizing effect of water. These data were complemented by measurements of hygral expansion strains caused by attraction of water to hydrophilic formulation ingredients.
A combined SAO and de-blocking filter architecture for HEVC video decoder

The up-coming video compression standard, high efficiency video coding (HEVC), reduces 50% bit rates in encoding video sequences with same picture quality compared to H.264/AVC. In the in-loop filter (LF) part of HEVC, sample adaptive offset (SAO) is newly added and de-blocking filter (DBF) has been changed a lot. Thus how to construct a high speed and low cost VLSI architecture for HEVC SAO and de-blocking filter is a challenge. In this article, we propose a HEVC LF architecture composed of fully utilized de-blocking filter and SAO. Block based SAO and DBF are employed in this architecture to achieve seamless pipeline between them. The implementation results show that it can be synthesized to 240MHz with 65nm technology. Thus this solution can process 3.84G pixels/s and support 4320p(7680×4320)@120fps decoding.
All at Once or One at a Time? A Randomized Controlled Trial Comparing Two Ways to Deliver Bibliotherapy for Panic Disorder

Bibliotherapy is potentially effective in the treatment of panic disorder (PD). A still unanswered question is whether pacing is important. This study was designed to test whether there is a difference between being assigned a full book as therapy and receiving one individual chapter every week (i.e. pacing). A total of 28 participants were randomized to either 10 paced chapters or one book with 10 chapters. To maximize compliance, short weekly telephone calls were added in both conditions (M = 17.8 min, SD = 4.2). Both treatments showed promising results, with effects maintained up to 2 years and with within-group effect sizes (Cohen's d) between 0.95 and 1.11. Pretreatment ratings of credibility were positively correlated with the change scores at both posttest and 2-year follow-up for three panic measures. Pacing of text material in bibliotherapy for PD is not needed, and all material can be provided at once when the treatment is guided by a therapist.
A High-precision Current Detection Circuit for Battery Management System

This paper proposes a current detection circuit (CDC) for battery management systems(BMS), comprising a high-performance programmable gain amplifier (PGA) and a 16-bit high-precision, low-power Delta Sigma ADC. The PGA utilizes a two-stage folded cascode operational amplifier with resistive feedback to achieve adjustable gain. The ADC employs a single-loop second-order feedback modulator structure with an oversampling ratio of 256. This design enhances the conversion accuracy and reduces the output noise of the PGA and the switched-capacitor integrator using chopper stabilization techniques. The entire current detection circuit is implemented using the ASMC 0.35um BCD process. The post-simulation results demonstrate that under a 5V power supply voltage, the PGA maintains stable gain from 0-40dB with a phase margin greater than 60 degrees. The low-frequency noise of the PGA is measured at 1.386nV/sqrt(Hz). The transient simulation reveals that when the PGA input voltage varies within the range of 10mV to 300mV, it undergoes different levels of amplification to produce output voltages ranging from 0V to 5V. The PGA exhibits good power supply rejection ratio (PSRR) ranging from 94-112dB at 1KHz. For the ADC, with a signal bandwidth of 1KHz and a sampling rate of 1.024MHz, the effective number of bits (ENOB) reaches 16.58 bits, and the modulator operates at a current of 100uA. The simulation result shows that the error of the current detection is 0.3mV.
A Compound Blind Digital Watermarking Technique for Image Authentication and Integrity using DCT and VC

this paper we propose a multiple digital watermarking scheme using DCT and VC to achieve both image authentication and integrity. We used two watermarks for embedding in to the host image. Unlike traditional watermarking schemes, the second watermarks are not embedded directly into the host image. The proposed technique proves that it is resilient to several attacks. Keywordigital watermarking, visual cryptography, DCT
Multiple Control Plane Joint Operation Method under Overlaid Cell Structure Environment for Future Mobile Communications

The use of very high frequencies (e.g., THz) in cellular mobile communications results in smaller cell sizes due to significant radio propagation loss, ultimately leading to the formation of ultra-dense networks (UDN). Additionally, due to their ultra-wideband nature, these frequencies are divided into multiple component carriers (CCs) to efficiently utilize the available radio resources. Applying carrier aggregation (CA) technology to these CCs enables high-capacity data transmission. However, the performance at the cell edge can be severely degraded or subject to significant variations. To address this issue, technologies such as coordinated multi-point (CoMP) or dual active protocol stack (DAPS) have been introduced, enabling some improvements in user plane (UP) performance. Nevertheless, when considering ultra-high-speed user equipment (UE) or UDN environments, it is still essential to consider cell-edge performance improvements not only on the UP side but also on the control plane (CP) side. In this paper, we assume an overlaid cell structure (OCS) environment where individual layer cell groups are established, allowing ensuring that cell edges between layers do not overlap and specific master nodes (MNs) to move within specific layers. Additionally, we propose the multiple control plane joint operation (MCPJO) method, which utilizes two or more control planes and wireless connectivity with two or more master nodes. This environment and method offer significant improvements in cell-edge performance by reducing fluctuations in user capacity and enhancing handover movement stability.