Miracle-dz/UniFAR-FTUs huggingface dataset:
Cyclic AMP response element binding (CREB) protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells

SOX3 is one of the earliest neural markers in vertebrates, playing the role in specifying neuronal fate. In this study we have established first functional link between CREB and human SOX3 gene which both have important roles in the nervous system throughout development and in the adulthood. Here we demonstrate both in vitro and in vivo that CREB binds to CRE half-site located -195 to -191 within the human SOX3 promoter. Overexpression studies with CREB or its dominant-negative inhibitor A-CREB indicate that this transcription factor acts as a positive regulator of basal SOX3 gene expression in NT2/D1 cells. This is further confirmed by mutational analysis where mutation of CREB binding site results in reduction of SOX3 promoter activity. Our results point at CREB as a positive regulator of SOX3 gene transcription in NT2/D1 cells, while its contribution to RA induction of SOX3 promoter is not prominent. [BMB Reports 2014; 47(4): 197-202]
Accent recognition using i-vector, Gaussian Mean Supervector and Gaussian posterior probability supervector for spontaneous telephone speech

In this paper, three utterance modelling approaches, namely Gaussian Mean Supervector (GMS), i-vector and Gaussian Posterior Probability Supervector (GPPS), are applied to the accent recognition problem. For each utterance modeling method, three different classifiers, namely the Support Vector Machine (SVM), the Naive Bayesian Classifier (NBC) and the Sparse Representation Classifier (SRC), are employed to find out suitable matches between the utterance modelling schemes and the classifiers. The evaluation database is formed by using English utterances of speakers whose native languages are Russian, Hindi, American English, Thai, Vietnamese and Cantonese. These utterances are drawn from the National Institute of Standards and Technology (NIST) 2008 Speaker Recognition Evaluation (SRE) database. The study results show that GPPS and i-vector are more effective than GMS in this accent recognition task. It is also concluded that among the employed classifiers, the best matches for i-vector and GPPS are SVM and SRC, respectively.
Exploring Simple Triangular and Hexagonal Grid Polygons Online

We investigate the online exploration problem (aka covering) of a short-sighted mobile robot moving in an unknown cellular environment with hexagons and triangles as types of cells. To explore a cell, the robot must enter it. Once inside, the robot knows which of the 3 or 6 adjacent cells exist and which are boundary edges. The robot's task is to visit every cell in the given environment and to return to the start. Our interest is in a short exploration tour; that is, in keeping the number of multiple cell visits small. For arbitrary environments containing no obstacles we provide a strategy producing tours of length S <= C + 1/4 E - 2.5 for hexagonal grids, and S <= C + E - 4 for triangular grids. C denotes the number of cells-the area-, E denotes the number of boundary edges-the perimeter-of the given environment. Further, we show that our strategy is 4/3-competitive in both types of grids, and we provide lower bounds of 14/13 for hexagonal grids and 7/6 for triangular grids.
The Interaction of Early Maternal Responsiveness and Children's Cognitive Abilities on Later Decoding and Reading Comprehension Skills

This longitudinal study evaluated the extent to which maternal responsiveness across early childhood and children's cognitive skills predicted children's 8-year decoding and reading comprehension skills for children who varied in biological risk (term, n = 83; preterm, n = 155). Patterns of maternal responsiveness during infancy (6, 12, and 24 months) and preschool (3 and 4 years) revealed 4 maternal clusters that varied in consistency and level of maternal responsiveness. Although not predictive of decoding skills, the interaction between children's 4-year cognitive ability and maternal responsiveness cluster predicted children's reading comprehension skills at 8 years of age, regardless of risk. Although consistently high levels of maternal responsive parenting across early childhood related to literacy outcomes for all children in the study, responsive parenting had a stronger relation to later reading comprehension skills for children with lower cognitive abilities, particularly when mothers demonstrated high responsiveness in children's infancy.
A noiseless code length method (NCLM) to estimate dimensionality of hyperspectral data

Hyperspectral image analysis has been subjected to many improvements made in past decade. Yet the accurate estimation of dimensionality is still a challenge. Since dimension estimation of the Hyperspectral data is the first step in analysis of an image, the accuracy of analysis results highly depends on the accuracy of the dimension estimation step. Mostly, existing methods isolate the process of dimension estimation and process of denoising which leads to an inaccurate estimation of constituent components in the signal. In this paper, the problem of estimating the dimensionality of Hyperspectral data using the concept of “noiseless code length” is addressed. In our proposed method, NCLM, a set of nested subsets including the Hyperspectral data is generated first and then an error comparison approach is utilized by estimating the noiseless data error rather than noisy data error used by the existing methods to find the optimum subset. It has been shown that the estimated noiseless error has a minimum that represents the accurate estimation of the dimensionality of Hyperspectral data. The comparison of NCLM to other methods shows a substantial improvement in estimation of dimensionality in Hyperspectral imagery.
Cauliflower Leave, an Agricultural Waste Biomass Adsorbent, and Its Application for the Removal of MB Dye from Aqueous Solution: Equilibrium, Kinetics, and Thermodynamic Studies

Cauliflower leaf powder (CLP), a biosorbent prepared from seasonal agricultural crop waste material, has been employed as a prospective adsorbent for the removal of a basic dye, methylene blue (MB) from aqueous solution by the batch adsorption method under varying conditions, namely, initial dye concentration, adsorbent dose, solution pH, and temperature. Characterization of the material by FTIR and SEM indicates the presence of functional groups and rough coarse surface suitable for the adsorption of methylene blue over it. Efforts were made to fit the isotherm data using Langmuir, Freundlich, and Temkin equation. The experimental data were best described by Freundlich isotherm model, with an adsorption capacity of 149.22 mg/g at room temperature. To evaluate the rate of methylene blue adsorption onto CLP, pseudo-first-order, pseudo-second-order, and intraparticle diffusion models were employed. The experimental data were best described by the pseudo-second-order kinetic model. Evaluation of thermodynamic parameters such as changes in enthalpy, entropy, and Gibbs' free energy showed the feasible, spontaneous, and exothermic nature of the adsorption process. On the basis of experimental results obtained, it may be concluded that the CLP prepared from agricultural waste has considerable potential as low-cost adsorbent in wastewater treatment for the removal of basic dye, MB.
Large Scale Lexical Analysis

The following paper presents a lexical analysis component as implemented in the PANACEA project. The goal is to automatically extract lexicon entries from crawled corpora, in an attempt to use corpus-based methods for high-quality linguistic text processing, and to focus on the quality of data without neglecting quantitative aspects. Lexical analysis has the task to assign linguistic information (like: part of speech, inflectional class, gender, subcategorisation frame, semantic properties etc.) to all parts of the input text. If tokens are ambiguous, lexical analysis must provide all possible sets of annotation for later (syntactic) disambiguation, be it tagging, or full parsing. The paper presents an approach for assigning part-of-speech tags for German and English to large input corpora (> 50 mio tokens), providing a workflow which takes as input crawled corpora and provides POS-tagged lemmata ready for lexicon integration. Tools include sentence splitting, lexicon lookup, decomposition, and POS defaulting. Evaluation shows that the overall error rate can be brought down to about 2% if language resources are properly designed. The complete workflow is implemented as a sequence of web services integrated into the PANACEA platform.
Evaluation of CFD to Determine Two-Dimensional Airfoil Characteristics for Rotorcraft Applications

The efficient prediction of helicopter rotor performance, vibratory loads, and aeroelastic properties still relies heavily on the use of comprehensive analysis codes by the rotorcraft industry. These comprehensive codes utilize look-up tables to provide two-dimensional aerodynamic characteristics. Typically these tables are comprised of a combination of wind tunnel data, empirical data and numerical analyses. The potential to rely more heavily on numerical computations based on Computational Fluid Dynamics (CFD) simulations has become more of a reality with the advent of faster computers and more sophisticated physical models. The ability of five different CFD codes applied independently to predict the lift, drag and pitching moments of rotor airfoils is examined for the SC1095 airfoil, which is utilized in the UH-60A main rotor. Extensive comparisons with the results of ten wind tunnel tests are performed. These CFD computations are found to be as good as experimental data in predicting many of the aerodynamic performance characteristics. Four turbulence models were examined (Baldwin-Lomax, Spalart-Allmaras, Menter SST, and k-ω ).
Infinitary control flow analysis: a collecting semantics for closure analysis

Defining the collecting semantics is usually the first crucial step in adapting the general methodology of abstract interpretation to the semantic framework or programming language at hand. In this paper we show how to define a collecting semantics for control flow analysis: due to the generality of the formulation we need to appeal to coinduction (or greatest fixed points) in order to define the analysis. We then prove the semantic soundness of the collecting semantics and that all totally deterministic instantiations have a least solution; this incorporates k-CFA, polymorphic splitting and a new class of uniform-k-CFA analyses.
Non-response in a cross-sectional study of respiratory health in Norway

Objectives Declining participation in epidemiological studies has been reported in recent decades and may lead to biased prevalence estimates and selection bias. The aim of the study was to identify possible causes and effects of non-response in a population-based study of respiratory health in Norway. Design The Telemark study is a longitudinal study that began with a cross-sectional survey in 2013. Setting In 2013, a random sample of 50 000 inhabitants aged 16–50 years, living in Telemark county, received a validated postal questionnaire. The response rate was 33%. In this study, a random sample of 700 non-responders was contacted first by telephone and then by mail. Outcome measures Response rates, prevalence and OR of asthma and respiratory symptoms based on exposure to vapours, gas, dust or fumes (VGDF) and smoking. Causes of non-response. Results A total of 260 non-responders (37%) participated. Non-response was associated with younger age, male sex, living in a rural area and past smoking. The prevalence was similar for responders and non-responders for physician-diagnosed asthma and several respiratory symptoms. The prevalence of chronic cough and use of asthma medication was overestimated in the Telemark study, and adjusted prevalence estimates were 17.4% and 5%, respectively. Current smoking was identified as a risk factor for respiratory symptoms among responders and non-responders, while occupational VGDF exposure was a risk factor only among responders. The Breslow-Day test detected heterogeneity between productive cough and occupational VGDF exposure among responders. Conclusions The Telemark study provided valid estimates for physician-diagnosed asthma and several respiratory symptoms, while it was necessary to adjust prevalence estimates for chronic cough and use of asthma medication. Reminder letters had little effect on risk factor associations. Selection bias should be considered in future investigations of the relationship between respiratory outcomes and exposures.
A Wideband CMOS Low Noise Amplifier Employing Noise and IM2 Distortion Cancellation for a Digital TV Tuner

A wideband CMOS low noise amplifier (LNA) with single-ended input and output employing noise and IM2 distortion cancellation for a digital terrestrial and cable TV tuner is presented. By adopting a noise canceling structure combining a common source amplifier and a common gate amplifier by current amplification, the LNA obtains a low noise figure and high IIP3. IIP2 as well as IIP3 of the LNA is important in broadband systems, especially digital terrestrial and cable TV applications. Accordingly, in order to overcome the poor IIP2 performance of conventional LNAs with single-ended input and output and avoid the use of external and bulky passive transformers along with high sensitivity, an IM2 distortion cancellation technique exploiting the complementary RF performance of NMOS and PMOS while retaining thermal noise canceling is adopted in the LNA. The proposed LNA is implemented in a 0.18 mum CMOS process and achieves a power gain of 14 dB, an average noise figure of 3 dB, an IIP3 of 3 dBm, an IIP2 of 44 dBm at maximum gain, and S11 of under -9 dB in a frequency range from 50 MHz to 880 MHz. The power consumption is 34.8 mW at 2.2 V and the chip area is 0.16 mm2.
The role of client motivation in workplace rehabilitation

Motivation has been recognised as an essential component in managing medical issues, adjusting to physical disability, cognitive impairment, returning to work, and improving psychosocial functioning. Rehabilitation aims to reduce the impact of impairments on activities of daily living and social role functioning, promoting both independence and social inclusion. This research explores the role of client motivation in workplace rehabilitation and demonstrates the implications for rehabilitation counselling practice. The research focuses on understanding the concept of motivation, reasons for its presence or absence, and why motivation is important to the workplace rehabilitation process. This study also explores significant influencing factors that may be utilised to increase motivation and promote more successful return to work outcomes, as well as considering the implications for rehabilitation practice and research.
Maryland Statewide PBIS Initiative

There is growing interest in positive behavior supports among state departments of education and local school systems as an efficient and effective strategy for addressing students' increasing and intensifying discipline needs. Positive Behavioral Interventions and Supports (PBIS) is one whole-school prevention strategy that alters the school environment by creating improved systems (e.g., discipline, reinforcement, and data management) and procedures (e.g., collection of office referral data, training, team-based decision making) to promote positive changes in student and teacher behaviors. This article describes a statewide systems approach to the implementation of PBIS. An overview of the PBIS Maryland multilevel implementation model is presented with a focus on school- and district-level structures that support implementation. Preliminary results are presented from the state's summative and formative evaluation being conducted in 467 schools trained in PBIS. The evaluation findings suggest that the state has developed an efficient statewide structure for promoting high-fidelity implementation of PBIS.
Human rights organizations and online agenda setting

Purpose – The purpose of this paper is to better understand agenda setting by international human rights organizations in the online environment and at the same time contribute to agenda‐setting theory. The role of non‐governmental organizations (NGOs) in the area of human rights is clarified, and agenda setting and related concepts are discussed.Design/methodology/approach – The study focuses on how attention is drawn to human rights issues in online communication by Human Rights Watch (HRW) and Amnesty International. A content analysis of online forums of HRW and Amnesty International was conducted by monitoring their web sites and Facebook and Twitter pages over a period of three months. In addition, two expert interviews with representatives of Amnesty Finland were conducted to better understand how the organization's online communication activities relate to its policies in drawing attention to human rights.Findings – Based on this study, drawing attention to human rights issues is a goal that leads .
Bladder Cancer in Relation to Cigarette Smoking 1

METHODS The importance of smoking-related variables in the development of The cases and controls used in this study were interviewed between bladder cancer was examined in data from a hospital-based case-control study of 1316 male and SOSfemale cases, and 3940 male and 1S04 female age-matched controls interviewed in 20 hospitals from 9 United States cities between 1969 and 1984. For male current smokers, odds ratios for number of cigarettes smoked per day (cpd) increased to approximately 2.5 for smokers of more than 20 cpd, after adjustment for duration and nonsmoking-related covariates. Above 20 cpd, no further increase in odds ratio was observed. In females, the adjusted odds ratios showed no significant effect of increasing cpd level. In males, the odds ratios for duration increased from 1.18 (0.522.72) in those who smoked for less than 20 years to 2.31 (1.65-3.24) in those who smoked for greater than 40 years. In females, the correspond ing odds ratios were 0.97 (0.27-3.44) and 1.62 (1.00-2.62). The results did not suggest an increased risk with early age at start of smoking in either sex. Ex-cigarette smokers, as a whole, had reduced odds ratios for bladder cancer, but the extent of the reduction was similar in short-term and longer-term quitters. The findings of this investigation support an association between smoking and bladder cancer. The pattern of risk associated with cpd and duration among current smokers and the early decline in risk associated with quitting are discussed in relation to possible mechanisms of bladder carcinogenesis.
A Neural Basis of Speech-in-Noise Perception in Older Adults

Objective: We investigated a neural basis of speech-in-noise perception in older adults. Hearing loss, the third most common chronic condition in older adults, is most often manifested by difficulty understanding speech in background noise. This trouble with understanding speech in noise, which occurs even in individuals who have normal-hearing thresholds, may arise, in part, from age-related declines in central auditory processing of the temporal and spectral components of speech. We hypothesized that older adults with poorer speech-in-noise (SIN) perception demonstrate impairments in the subcortical representation of speech. Design: In all participants (28 adults, age 60-73 yr), average hearing thresholds calculated from 500 to 4000 Hz were ≤25 dB HL. The participants were evaluated behaviorally with the Hearing in Noise Test (HINT) and neurophysiologically using speech-evoked auditory brainstem responses recorded in quiet and in background noise. The participants were divided based on their HINT scores into top and bottom performing groups that were matched for audiometric thresholds and intelligent quotient. We compared brainstem responses in the two groups, specifically, the average spectral magnitudes of the neural response and the degree to which background noise affected response morphology. Results: In the quiet condition, the bottom SIN group had reduced neural representation of the fundamental frequency of the speech stimulus and an overall reduction in response magnitude. In the noise condition, the bottom SIN group demonstrated greater disruption in noise, reflecting reduction in neural synchrony. The role of brainstem timing is particularly evident in the strong relationship between SIN perception and quiet-to-noise response correlations. All physiologic measures correlated with SIN perception. Conclusion: Adults in the bottom SIN group differed from the audiometrically matched top SIN group in how speech was neurally encoded. The strength of subcortical encoding of the fundamental frequency appears to be a factor in successful speech-in-noise perception in older adults. Given the limitations of amplification, our results suggest the need for inclusion of auditory training to strengthen central auditory processing in older adults with SIN perception difficulties.
Nephrotoxin exposure in utero reduces glomerular number in sclerosis-prone but not sclerosis-resistant mice.

BACKGROUND We have previously found that nephron number was not fixed, that is, there was a direct correlation between low birth weight and decreased nephron number in infants. In sclerosis-prone rats, we found that gentamicin exposure in utero induced a reduction in glomerular number and aggravated glomerulosclerosis in adults. In mice, we found that an inborn 50% reduction in nephron number, caused by the Os mutation, was associated with glomerulosclerosis in sclerosis-prone (ROP+/+) mice, but not in sclerosis-resistant (C57BL/6J) mice. Because the genetic background determined the response to decreased nephron number, we asked whether the susceptibility changes in glomerular number and glomerulosclerosis were linked. METHODS Gentamicin was administered before and after the onset of fetal nephrogenesis. (1) Prior to the onset of nephrogenesis, two groups of pregnant mice were treated from embryonic day (E) E8 to E12. In group A, early glomerular development was studied by placing ureteric ridges removed on E12 in vitro for four days, following which the ureteric bud branches and glomeruli were counted using lectin staining. In group B, nephron number was determined in spontaneously delivered 14-day-old (14PN) pups by counting glomeruli. (2) After the onset of nephrogenesis, to determine the direct effects of gentamicin on nephron induction, ureteric ridges were placed in organ culture at E12 of normal gestation, in the presence or absence of gentamicin. The number of glomeruli and ureteric bud branches were counted after six days in culture. RESULTS A decrease in glomerular number and ureteric bud branches was observed in sclerosis-prone (ROP+/+) mice, irrespective of whether gentamicin was administered prior to or after the onset of nephrogenesis. Glomerular number and ureteric bud branching were not decreased by gentamicin in sclerosis-resistant (C57BL/6) mice. CONCLUSIONS These data provide evidence that there is a positive correlation between the susceptibility to glomerulosclerosis in adulthood and a reduction in nephron number in utero. Thus, exposure to nephrotoxins in utero compounds the risk of renal failure as an adult in sclerosis-prone individuals.