Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy and Safety of Surgery for Mild Degenerative Cervical Myelopathy: Results of the AOSpine North America and International Prospective Multicenter Studies

Abstract BACKGROUND There is controversy over the optimal treatment strategy for patients with mild degenerative cervical myelopathy (DCM). OBJECTIVE To evaluate the degree of impairment in baseline quality of life as compared to population norms, as well as functional, disability, and quality of life outcomes following surgery in a prospective cohort of mild DCM patients undergoing surgical decompression. METHODS We identified patients with mild DCM (modified Japanese Orthopaedic Association [mJOA] 15 to 17) enrolled in the prospective, multicenter AOSpine CSM-NA or CSM-I trials. Baseline quality of life Short Form-36 version 2 (SF-36v2) was compared to population norms by the standardized mean difference (SMD). Outcomes, including functional status (mJOA, Nurick grade), disability (NDI [Neck Disability Index]), and quality of life (SF-36v2), were evaluated at baseline and 6 mo, 1 yr, and 2 yr after surgery. Postoperative complications within 30 d of surgery were monitored. RESULTS One hundred ninety-three patients met eligibility criteria. Mean age was 52.4 yr. There were 67 females (34.7%). Patients had significant impairment in all domains of the SF-36v2 compared to population norms, greatest for Social Functioning (SMD –2.33), Physical Functioning (SMD –2.31), and Mental Health (SMD –2.30). A significant improvement in mean score from baseline to 2-yr follow-up was observed for all major outcome measures, including mJOA (0.87, P < .01), Nurick grade (–1.13, P < .01), NDI (–12.97, P < .01), and SF-36v2 Physical Component Summary (PCS) (5.75, P < .01) and Mental Component Summary (MCS) (6.93, P < .01). The rate of complication was low. CONCLUSION Mild DCM is associated with significant impairment in quality of life. Surgery results in significant gains in functional status, level of disability, and quality of life.
Organization of the ferritin genes in Drosophila melanogaster.

The organization of two closely clustered genes, Fer1HCH and Fer2LCH, encoding the heavy-chain homolog (HCH) and the light-chain homolog (LCH) subunits of Drosophila melanogaster ferritin are reported here. The 5019-bp sequence of the cluster was assembled from genomic fragments obtained by polymerase chain reaction (PCR) amplification of genomic DNA and from sequences obtained from the Berkeley Drosophila Genome Project (BDGP) (http://www.fruitfly.org). These genes, located at position 99F1, have different exon-intron structures (Fer1HCH has three introns and Fer2LCH has two introns) and are divergently transcribed. Computer analysis of the possibly shared promoter regions revealed the presence of putative metal regulatory elements (MREs), a finding consistent with the upregulation of these genes by iron, and putative NF-kappaB-like binding sites. The structure of two other invertebrate ferritin genes, from the nematode Caenorhabditis elegans (located on chromosomes I and V), was also analyzed. Both nematode genes have two introns, lack iron-responsive elements (IREs), and encode ferritin subunits similar to vertebrate H chains. These findings, along with comparisons of ferritin genes from invertebrates, vertebrates, and plants, suggest that the specialization of ferritin H and L type chains, the complex exon-intron organization of plant and vertebrate genes, and the use of the IRE/iron regulatory protein (IRP) mechanism for regulation of ferritin synthesis are recent evolutionary acquisitions.
The Surgical Management of Lung Cancer

Since the introduction of the pneumonectomy as a technically feasible strategy for the treatment of lung cancer, surgical resection has played a pivotal role in the management of early stage non-small cell lung carcinoma (NSCLC). In the last two decades, surgical, medical, and radiation oncologists have produced a growing body of evidence to support the combination of neoadjuvant or adjuvant treatments with standard surgical resection, to improve disease-free and overall survival for specific patient subgroups. Furthermore, alternatives to aggressive surgical management have evolved for patients who are medically inoperable due to compromised pulmonary function or other comorbidities. In this review, surgical options and multimodal treatment strategies are discussed, as well as completed and ongoing clinical trials addressing the surgical management of NSCLC.
A study on the L∞/L2 performance of a computed torque controller

This paper introduces a new performance analysis method for a computed torque controller against disturbances with the framework of the induced norm from L<inf>2</inf> to (which is also denoted by the L<inf>∞</inf>/L<inf>2</inf>-induced norm). To this end, we first derive a linear time-invariant (LTI) representation of the system obtained by connecting a robot manipulator and a computed torque controller. We then formulate the problem definition associated with the L<inf>∞</inf>/L<inf>2</inf> performance of the computed torque controller in which the maximum magnitude of the output for disturbances of finite energy is adopted as the performance measure. We next show that the L<inf>∞</inf>/L<inf>2</inf>-induced norm of the derived LTI system can be explicitly computed by solving the continuous-time Lyapunov equation. Finally, some experiment results are provided to demonstrate the effectiveness of the introduced performance analysis method.
Autoimmunity in dengue virus infection

Dengue haemorrhagic fever (DHF) is a complicated disease associated with viral and immune pathogenesis. There is still no effective vaccine to prevent the progression of DHF because of its undefined pathogenic mechanisms. The generation of autoimmunity in dengue virus (DEN) infection has been implicated in dengue pathogenesis. Based on our previous studies showing antibodies (Abs) against DEN nonstructural protein 1 (NS1) cross-reacted with human platelets and endothelial cells, a mechanism of molecular mimicry may contribute to autoantibody (autoAb) production. Here, the generation of autoAbs against human endothelial cells in patients infected with different DEN serotypes is shown. The levels of autoAbs present in different disease stages of DHF and the induction of endothelial cell apoptosis by patient sera were also determined. The results suggest that autoimmune responses are implicated in dengue disease pathogenesis and cause concern in vaccine development.
Distributed power control for OFDMA based spatial multiplexing multi-hop systems

In this paper, a distributed power control algorithm is proposed to perform adaptive spatial multiplexing for the relay enhanced orthogonal frequency division multiple access (OFDMA) cellular systems. As the optimal spatial multiplexing problem is non-convex, we utilize the distributed iteration method to achieve its near-optimal solution. By determining the restriction on the transmit power for each subcarrier, the individual power allocation at the base station (BS) and the relay station (RS) can always converge to some desirable Nash Equilibriums with satisfying performance. Simulation results show that the proposed distributed power control algorithm provides significant gain in system transmit rate over the traditional iterative water-filling scheme.
Paramedic Perspectives on Barriers to Prehospital Acute Stroke Recognition

ABSTRACT Background: Emergency Medical Service (EMS) providers are tasked with rapid evaluation, stabilization, recognition, and transport of acute stroke patients. Although prehospital stroke scales were developed to assist with stroke recognition, unrecognized challenges exist in the prehospital setting that hinder accurate assessment of stroke. The goal of this qualitative study was to systematically understand the challenges and barriers faced by paramedics in recognizing stroke presentations in the field. Methods: Paramedics from 12 EMS agencies serving a mix of rural, suburban, and urban communities in the State of California participated in five focus group discussions. Group size ranged from 3–8, with a total of 28 participants. Demographics of the participants were collected and focus group recordings were transcribed verbatim. Transcripts were subjected to deductive and inductive coding, which identified recurrent and divergent themes. Results: Strong consensus existed around constraints to prehospital stroke recognition; participants cited the diversity of stroke presentations, linguistic diversity, and exam confounded by alcohol and or drug use as barriers to initial evaluation. Also, lack of educational feedback from hospital staff and physicians and continuing medical education on stroke were reported as major deterrents to enhancing their diagnostic acumen. Across groups, participants reported attempting to foster relationships with hospital personnel to augment their educational needs, but this was easier for rural than urban providers. Conclusions: While challenges to stroke recognition in the field were slightly different for rural and urban EMS, participants concurred that timely, systematic feedback on individual patients and case-based training would strengthen early stroke recognition skills.
Sharp Convergence Rates for Langevin Dynamics in the Nonconvex Setting

We study the problem of sampling from a distribution $p^*(x) \propto \exp\left(-U(x)\right)$, where the function $U$ is $L$-smooth everywhere and $m$-strongly convex outside a ball of radius $R$, but potentially nonconvex inside this ball. We study both overdamped and underdamped Langevin MCMC and establish upper bounds on the number of steps required to obtain a sample from a distribution that is within $\epsilon$ of $p^*$ in $1$-Wasserstein distance. For the first-order method (overdamped Langevin MCMC), the iteration complexity is $\tilde{\mathcal{O}}\left(e^{cLR^2}d/\epsilon^2\right)$, where $d$ is the dimension of the underlying space. For the second-order method (underdamped Langevin MCMC), the iteration complexity is $\tilde{\mathcal{O}}\left(e^{cLR^2}\sqrt{d}/\epsilon\right)$ for an explicit positive constant $c$. Surprisingly, the iteration complexity for both these algorithms is only polynomial in the dimension $d$ and the target accuracy $\epsilon$. It is exponential, however, in the problem parameter $LR^2$, which is a measure of non-log-concavity of the target distribution.
Gibberellins Promote Vegetative Phase Change and Reproductive Maturity in Maize

Postembryonic shoot development in maize (Zea mays L.) is divided into a juvenile vegetative phase, an adult vegetative phase, and a reproductive phase that differ in the expression of many morphological traits. A reduction in the endogenous levels of bioactive gibberellins (GAs) conditioned by any one of the dwarf1, dwarf3, dwarf5, or anther ear1 mutations in maize delays the transition from juvenile vegetative to adult vegetative development and from adult vegetative to reproductive development. Mutant plants cease producing juvenile traits (e.g. epicuticular wax) and begin producing adult traits (e.g. epidermal hairs) later than wild-type plants. They also cease producing leaves and begin producing reproductive structures later than wild-type plants. These mutations greatly enhance most aspects of the phenotype of Teopod1 and Teopod2, suggesting that GAs suppress part but not all of the Teopod phenotype. Application of GA3 to Teopod2 mutants and Teopod1,dwarf3 double mutants confirms this result. We conclude that GAs act in conjunction with several other factors to promote both vegetative and reproductive maturation but affect different developmental phases unequally. Furthermore, the GAs that regulate vegetative and reproductive maturation, like those responsible for stem elongation, are downstream of GA20 in the GA biosynthetic pathway.
Digital Educational Games

Our main research question is how the choice of game type influences the success of digital educational games (DEGs), where success is defined as significant domain-specific knowledge gain (learning outcome) with positive player experience. We propose a methodological framework to address this question. The comparison of different game types is based on the previously developed Game Elements-Attributes Model (GEAM) and the Game Genre Map, which summarise game features and their relations. In addition, we present a research model considering the impact of player characteristics on learning outcome and player experience as well as their interrelation. Two empirical studies were conducted with 280 students. The application domain was computer programming. Study 1 compared three DEGs of the Mini-Game genre, differing in a single GEAM attribute—time pressure vs. puzzle solving and abstract vs. realistic settings. Study 2 compared DEGs of different genres, which vary in the implementation of several GEAM attributes. None of the player characteristics were found to be statistically significant factors. For both studies, significant differences were found in learning outcomes, for Study 2 also in some of the player experience dimensions. GEAM was demonstrated as a promising framework for games user research.
Thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor SB-505124 for glaucoma filtration surgery

The purpose of this study is to investigate a thermoreversible gel using Pluronic® F-127 to deliver an activin receptor-like kinase 5 (ALK-5) inhibitor SB-505124 in glaucoma filtration surgery (GFS). The gel was characterized for in vitro drug release and viscosity studies. Cytotoxicity of Pluronic® F-127 was examined by MTT assay using cultured rabbit subconjunctival fibroblasts. In addition, Pluronic® F-127 gel (18% w/v) containing 5 mg of SB-505124 was applied at the surgical site in an in vivo rabbit GFS model. In the in vitro viscosity study, the gel showed a change in viscosity (from 1000 cps to 45,000 cps) from low temperature (10°C) to body temperature (37°C). The in vitro drug release study demonstrated 100% drug release within 12 h. The gel did not show cytotoxicity to the cultured rabbit subconjunctival cells by MTT assay. In the in vivo rabbit GFS model, the drug was successfully delivered by injection and no severe post-surgical complications were observed. A thermoreversible gel system with SB-505124 was successfully prepared and delivered for the rabbit GFS model, and it may provide a novel delivery system in GFS.
Can Music Be Used To Teach Reading

There are several possible reasons to hypothesize that instruction in music may help children acquire reading skills. First, music and written text both involve formal written notation which must be read from left to right. In both cases, the written code maps onto a specific sound. Perhaps practice in reading music notation makes the reading of linguistic notation an easier task.1 Second, skill in reading requires a sensitivity to phonological distinctions, and skill in music listening requires a sensitivity to tonal distinctions. Perhaps experience in listening to music trains a general kind of auditory sensitivity that is as useful in listening to music as it is in perceiving phonological distinctions.2
SIPS: Unsupervised Succinct Interest Points

Detecting interest points is a key component of vision-based estimation algorithms, such as visual odometry or visual SLAM. Classically, interest point detection has been done with methods such as Harris, FAST, or DoG. Recently, better detectors have been proposed based on Neural Networks. Traditionally, interest point detectors have been designed to maximize repeatability or matching score. Instead, we pursue another metric, which we call succinctness. This metric captures the minimum amount of interest points that need to be extracted in order to achieve accurate relative pose estimation. Extracting a minimum amount of interest points is attractive for many applications, because it reduces computational load, memory, and, potentially, data transmission. We propose a novel reinforcement- and ranking-based training framework, which uses a full relative pose estimation pipeline during training. It can be trained in an unsupervised manner, without pose or 3D point ground truth. Using this training framework, we present a detector which outperforms previous interest point detectors in terms of succinctness on a variety of publicly available datasets.
Feasibility for Utilizing IEEE 802.15.4 Compliant Radios Inside Rotating Electrical Machines for Wireless Condition Monitoring Applications

The conventional condition monitoring systems for rotating electrical machines are predominantly based on externally available signals, while the internal signals, especially on the rotor, remain relatively unexplored. To access these internal signals, wireless sensors offer an effective solution in terms of cost and ease of deployment. However, the environment inside an electrical machine deviates from a typical wireless RF application and communication link reliability under such scenarios needs to be assessed. This paper explores the feasibility of utilizing the ubiquitous IEEE 802.15. 4-2.4 GHz compliant radios for wireless sensor deployment inside an electrical machine. A series of measurements are made to experimentally investigate the link quality characteristics under the prominent environmental factors such as the multipath effect, Doppler shift, magnetic field interference, and shielding effect of the enclosure. Packet reception rate, received signal strength and link quality indicator are used as the metrics to quantify the link performance. It is observed that contrary to popular belief, the link quality between nodes inside the machine is not deteriorated and in fact is found to be enhanced. A poor link quality is observed for the connection between nodes placed inside and outside the machine. Moreover, the link quality is highly dependent on spatial position and prone to interference. However, a sufficiently stable link can be established at the expense of high transmit power. These experimental findings indicate that wireless RF-based sensor nodes can be deployed inside an electrical machine and it opens an opportunity to explore invasive condition monitoring systems.
Cardiac rehabilitation fitness changes and subsequent survival

Aims Assessments of cardiac rehabilitation (CR) in coronary heart disease (CHD) cohorts usually examine mortality in aggregate. This study examines the prognosis and characteristics of patients who enrolled and completed CR, stratified by their level of improvement in cardiorespiratory fitness (CRF) by examining the characteristics, outcomes and predictors of non-response in CRF (NonRes) compared with low-responders (LowRes) and high-responders (HighRes) after CR. Methods and results A total of 1171 CHD patients were referred for a phase II CR programme after therapy for an acute coronary syndrome, coronary artery bypass graft procedure or a percutaneous coronary intervention between 1 January 2000 and 30 June 2013 underwent cardiopulmonary exercise testing before and after CR. This cohort was divided according to absolute improvements in CRF (i.e. change in peak oxygen consumption expressed in mL⋅kg-1⋅min-1). Mortality was analysed after 0.5-13.4 years of follow-up (mean 6.4 years). A total of 266 (23%) subjects were NonRes. After adjustment for body mass index, age, gender, left ventricular ejection fraction and baseline CRF, NonRes, and LowRes had a statistically significant three-fold and two-fold higher mortality, respectively, when compared with HighRes (HighRes 8% vs. LowRes 17% vs. NonRes 22%; P < 0.001). Age, female gender, baseline CRF, hostility, and presence of diabetes were significant predictors of NonRes and LowRes. In addition, higher waist circumference was a predictor of NonRes. Conclusion Significant proportions of subjects referred to CR have no/low improvement in CRF and higher associated mortality risks. Greater attention is required to increase improvements in CRF following CR and avoid NonRes.
Predicting high school students’ health-promoting lifestyle: a test of the information, motivation, behavioral skills model

Abstract Background and aim Expenditure on adolescents’ health promotion is critical to enhancing quality of life and fundamental for the prosperity of countries. This study tried to investigate the relationships between information-motivation-behavioral skills (IMB) model constructs as predictors of high school student’s health-promoting lifestyle (HPL) in Southwest Iran. Methods This cross-sectional descriptive-analytic study was conducted on 400 students in Southwest Iran. Sample size required for this study was obtained using Soper’s structural equation modeling (SEM) calculator. The stratified random sampling method was used in this study. A path analysis was taken to evaluate the HPL main determinants utilizing SEM. Results Information only had a significant indirect relationship with adolescents’ HPL. But, both motivation and behavioral skills constructs had significant direct and indirect relationship with adolescents’ HPL. The behavioral skill construct was the most imperative predictor variable. In general, behavioral skills construct (75%), motivation (66%) and knowledge (50%) constructs had the highest impact on HPL. The IMB model was able to explain 71% of the variance in adolescents’ HPL. Conclusion The findings of the study showed that the IMB model was appropriate for explaining adolescents’ HPL. It is necessary that actions are taken to improve behavioral skills and promote adolescents’ HPL.
Malaria increased the risk of stunting and wasting among young children in Ethiopia: Results of a cohort study

Introduction Given the high prevalence of malnutrition in a malaria-endemic setting, improving nutritional status could serve as a tool to prevent malaria. However, the relationship between the two conditions remains unclear. Therefore, this study assessed the association between under-nutrition and malaria among a cohort of children aged 6 to 59 months old. Methods Two cohorts of children were followed for 89 weeks in a rural Rift Valley area of Ethiopia. In the first approach (malaria-malnutrition), a cohort of 2,330 non-stunted and 4,204 non-wasted children were included to assess under-nutrition (outcome) based on their previous malaria status (exposure). In the second approach (malnutrition–malaria), a cohort of 4,468 children were followed-up to measure malaria (outcome), taking under-nutrition as an exposure. A weekly home visit was carried out to identify malaria cases. Four anthropometry surveys were conducted, and generalized estimating equation (GEE) method was used to measure the association between undernutrition and malaria. Results The prevalence of stunting was 44.9% in December 2014, 51.5% in August 2015, 50.7% in December 2015 and 48.1% in August 2016. We observed 103 cases with 118 episodes of malaria, 684 new stunting and 239 new wasting cases. The incidence rate per 10,000 weeks of observation was 3.8 for malaria, 50.4 for stunting and 8.2 for wasting. Children with malaria infection, [Adjusted Odds Ratio (AOR) = 1.9; 95% Confidence Interval (CI), 1.2–2.9)] and younger age (AOR = 1.3; 95% CI, 1.1–1.5) were more likely to be stunted. Furthermore, children with malaria infection (AOR = 8.5; 95% CI, 5.0–14.5) and young age group (AOR = 1.6; 95% CI, 1.2–2.1) were more likely to be wasted. However, stunting and wasting were not risk factors of subsequent malaria illness. Conclusions Malaria infection was a risk factor for stunting and wasting, but stunting or wasting was not associated with subsequent malaria illness. As our study shows that malaria is a risk factor for stunting and wasting, a close follow-up of the nutritional status of such children may be needed. Trial registration PACT R2014 11000 882128 (8 September 2014).