Miracle-dz/UniFAR-FTUs huggingface dataset:
Mutation affecting the expression of immunoglobulin variable regions in the rabbit.

We have found a variant of the allotype allele a2 in the rabbit, which presumably arose by mutation, that segregates as expected for an allele at the a locus. This allele is called "ali" and the corresponding rabbit strain is called "Alicia. " In heterozygous animals (ali/a1 and ali/a3) the concentration of a2 molecules is lower by a factor of 1000 than in standard a2/a2 homozygotes. In homozygous ali/ali individuals the a2 concentration varies with age--i.e., very low in young rabbits and higher in older ones--but it never reaches normal levels. The low level of a2 is compensated by increased amounts of a-negative molecules. Southern blot analysis did not reveal any gross changes in the intron between JH and C mu (joining region of immunoglobulin heavy chain and constant region of immunoglobulin mu chain) or in the number of VH gene segments encoding a locus specificities. We suggest that the ali phenotype is due to a mutation in a control element.
Solution structure of the His 12 → Cys mutant of the N‐terminal zinc binding domain of HIV‐1 integrase complexed to cadmium

The solution structure of His 12 → Cys mutant of the N‐terminal zinc binding domain (residues 1–55; IN1–55) of HIV‐1 integrase complexed to cadmium has been solved by multidimensional heteronuclear NMR spectroscopy. The overall structure is very similar to that of the wild‐type N‐terminal domain complexed to zinc. In contrast to the wild‐type domain, however, which exists in two interconverting conformational states arising from different modes of coordination of the two histidine side chains to the metal, the cadmium complex of the His 12 → Cys mutant exists in only a single form at low pH. The conformation of the polypeptide chain encompassing residues 10–18 is intermediate between the two forms of the wild‐type complex.
Study on the experiment of photopolymer resin solidification

In the process of light solidification, the solidified distortion of photopolymer resin is a vital control factor for affecting the accuracy of the shape and dimension of parts. This article studies the rule between the distortion and the technology parameters including illumination power, distance and time via experiment. A series of reasonable parameters is determined with the hybrid optimization method of orthogonal experiment, Neural Network and Genetic Algorithm, which can make the solidified distortion of photopolymer resin least and further perfect the traditional solidification experimental model.
Diagnosis of Arrhythmia Using Neural Networks

This dissertation presents an intelligent framework for classification of heart arrhythmias. It is a framework of cascaded discrete wavelet transform and the Fourier transform as preprocessing stages for the neural network. This work exploits the information about heart activity contained in the ECG signal; the power of the wavelet and Fourier transforms in characterizing the signal and the power learningpower of neural networks. Firstly, the ECG signals are four-level discrete wavelet decomposed using a filter-bank and mother wavelet 'db2'. Then all the detailed coefficients were discarded, while retaining only the approximation coefficients at the fourth level. The retained approximation coefficients are Fourier transformed using a 16-point FFT. The FFT is symmetrical, therefore only the first 8-points are sufficient to characterize the spectrum. The last 8-points resulting from theFFTare discarded during feature selection. The 8-point feature vector is then used to train a feedforward neural network with one hidden layer of 20-units and three outputs. The neural network is trained by using the Scaled Conjugate Gradient Backpropagation algorithm (SCG). This was implemented in a MATLAB environment using the MATLAB GUINeural networktoolbox. This approach yields an accuracy of 94.66% over three arrhythmia classes, namely the Ventricular Flutter (VFL), the Ventricular Tachycardia (VT) and the Supraventricular Tachyarrhythmia (SVTA). We conclude that for the amount of information retained and the number features used the performance is fairly competitive.
CRED: a rapid peak caller for Chem-seq data

1 Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, Chuo-ku, Chiba, Japan 2 Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Koto-ku, Tokyo, Japan 3 Institute of Medical Informatics, National Cheng Kung University, Tainan, Taiwan 4 Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan
Public faces? A critical exploration of the diffusion of face recognition technologies in online social networks

In recent years, we have witnessed a rapid spread of biometric technologies from the security domain to commercial and social media applications. In this article, we critically explore the repercussions of this diffusion of face recognition to everyday contexts with an in-depth analysis of Facebook’s “tag suggestions” tool which first introduced the technology to on-line social networks. We use Nissenbaum’s framework of contextual integrity to show how the informational norms associated with biometrics in security and policing - their contexts of emergence - are grafted on-line social networks onto their context of iteration. Our analysis reveals a process that has inadvertently influenced the way users understand face recognition, precluding critical questioning of its wider use. It provides an important deepening of contextually-driven approaches to privacy by showing the process through which contexts are co-constitutive of informational norms. Citizens are also offered a critical tool for understanding the trajectory of biometrics and reflect on the data practices associated with the use of face recognition in social media and society at large.
Metabolite profiling in rat urine by liquid chromatography/electrospray ion trap mass spectrometry. Application to the study of heavy metal toxicity.

This work reports the use of reverse-phase liquid chromatography coupled to electrospray ion trap (QIT) mass spectrometry for the analysis of the metabolome in rat urine. An injection of 20 microL of urine into the chromatographic system is followed by a slow gradient elution and mass spectrometric detection in the scanning mode from m/z 100-1000 in both positive and negative modes. Over a time scale of 90 min, 30 and 20 resolved peaks were observed in the positive and the negative modes, respectively, corresponding to the presence of a few hundred m/z ratios. By using a QIT analyzer, data-dependent tandem mass spectrometry of selected m/z ratios identified several compounds in rat urine and characterized various chemical families, including carboxylic acids, amines, sulfated compounds, glucuronides and glycosides, by the observation of characteristic fragment ions or neutral losses. The method has been applied to the investigation of the chronic toxicity of heavy metals in rat urine. A few tens of m/z ratios, differing in intensity more than threefold from control values, were observed in both positive and negative modes. The time variations for some selected ions suggest that LC/ESI-MS could allow selective characterization of biomarkers in response to specific toxic compounds.
Determinants of Enterprise Risk Management (ERM): A Proposed Framework for Malaysian Public Listed Companies

Enterprise Risk Management (ERM) has become an important subject of increasing interest among businesses and industries throughout the world. Along the same note, ERM is considered a critical management practice for companies to mitigate risks effectively. The main objective of this paper is to propose a conceptual framework for determinants of companies in Malaysia that implement ERM. From the review of various literatures available in this particular area of interest, several factors are found to be the main determinants of companies that implement ERM. Such factors are the presence of chief risk officer, leverage, profitability, international diversification, majority shareholder, size and turnover.
Semiparametric Estimation in Simultaneous Equations of Time Series Models

A system of vector semiparametric nonlinear time series models is studied with possible dependence structures and nonstationarities in the parametric and nonparametric components. The parametric regressors may be endogenous while the nonparametric regressors are strictly exogenous. The parametric regressors may be stationary or nonstationary and the nonparametric regressors are nonstationary time series. Semiparametric least squares (SLS) estimation is considered and its asymptotic properties are derived. Due to endogeneity in the parametric regressors, SLS is not consistent for the parametric component and a semiparametric instrumental variable least squares (SIVLS) method is proposed instead. Under certain regularity conditions, the SIVLS estimator of the parametric component is shown to be consistent with a limiting normal distribution. Interestingly, the rate of convergence in the parametric component depends on the properties of the regressors. It has been shown that the conventional rate is still achievable even when nonstationarity is involved in both the regressors.
Incentivize Multi-Class Crowd Labeling Under Budget Constraint

Crowdsourcing systems allocate tasks to a group of workers over the Internet, which have become an effective paradigm for human-powered problem solving, such as image classification, optical character recognition, and proofreading. In this paper, we focus on incentivizing crowd workers to label a set of multi-class labeling tasks under strict budget constraint. We properly profile the tasks’ difficulty levels and workers’ quality in crowdsourcing systems, where the collected labels are aggregated with sequential Bayesian approach. To stimulate workers to undertake crowd labeling tasks, the interaction between workers and the platform is modeled as a reverse auction. We reveal that the platform utility maximization could be intractable, for which an incentive mechanism that determines the winning bid and payments with polynomial-time computation complexity is developed. Moreover, we theoretically prove that our mechanism is truthful, individually rational, and budget feasible. Through extensive simulations, we demonstrate that our mechanism utilizes budget efficiently to achieve high platform utility with polynomial computation complexity.
Decrements in Sustained Attention Across Trials in a Continuous Performance Test: Associations With Social Functioning in Schizophrenia

Deficits in attention are a stable feature of schizophrenia and likely to interfere with social function. In this study, we explored whether 2 types of attentional dysfunction, increasingly variable and declining reaction times over the course of a continuous performance task, were linked to psychosocial deficits. Participants were 102 adults with schizophrenia spectrum disorders in ongoing outpatient treatment. Concurrent assessments included the Conners' Continuous Performance Test II, the Inventory of Interpersonal Problems, and the Ways of Coping Questionnaire. Analysis of covariance controlling for global performance on the Continuous Performance test suggested that participants with a pattern of increasingly variable performance on the task (n = 14) reported being more domineering and taken advantage of socially, than those whose performance was less variable (n = 88). No differences were found between groups for assessments of coping or between participants who showed a declining vs non-declining reaction time.
Transport Layer Security (TLS) / Datagram Transport Layer Security (DTLS) Profiles for the Internet of Things

A common design pattern in Internet of Things (IoT) deployments is the use of a constrained device that collects data via sensors or controls actuators for use in home automation, industrial control systems, smart cities, and other IoT deployments. This document defines a Transport Layer Security (TLS) and Datagram Transport Layer Security (DTLS) 1.2 profile that offers communications security for this data exchange thereby preventing eavesdropping, tampering, and message forgery. The lack of communication security is a common vulnerability in IoT products that can easily be solved by using these well- researched and widely deployed Internet security protocols.
Association between hybrid status and reproductive success of captive male and female rhesus macaques (Macaca mulatta) at the California National Primate Research Center (CNPRC)

The California National Primate Research Center (CNPRC) houses more than 1,000 rhesus macaques (Macaca mulatta) of mixed Chinese–Indian ancestry. Most of these animals are kept in outdoor field cages, the colony's long term breeding resource. Since 2001, hybrids comprised between 4 and 49% of the field cage populations, but in most cases have represented a maximum of 10% of those populations. The increasing prevalence of hybrids is partly due to management efforts to distribute genetic diversity effectively and minimize genetic subdivisions. However, other factors may also contribute to the spread of hybrids within the colony, most notably variance in socio‐sexual behaviors and physical attributes. It is known that hybrids of some species exhibit heterosis, such as early maturation, that can enhance reproductive success, and anecdotal observations of mixed groups of hybrid, Indian and Chinese animals at the CNPRC suggest that hybrids are more sexually active. To determine whether hybrids experienced a reproductive advantage, a study was conducted using birth records of 5,611 offspring born in the CNPRC colony between 2003 and 2009. We found that while the degree of Chinese ancestry (DCA) appeared to influence the maturational schedule of both males and females (maturation was inversely related to proportion of Chinese ancestry), DCA had no independent effect on either male or female RS or rank. Therefore, we have found no evidence that a hybrid phenotype confers an absolute reproductive advantage in our colony. Am. J. Primatol. 73:671–678, 2011. © 2011 Wiley‐Liss, Inc.
Mannitol and isosorbide. Sequential effects on intraocular pressure, serum osmolality, sodium, and solids in normal subjects.

The sequential effects of intravenously administered mannitol and oral isosorbide on intraocular pressure, serum osmolality, sodium, and total solids were measured in normal volunteers. Various dose regimens were used to provide optimal schedules for clinical testing. Additionally, a useful correlation between sequential changes in serum and changes of intraocular pressure was sought, but not found. Although both drugs produced prompt intraocular pressure reduction and serum osmolality elevation, only mannitol caused depression of total serum solids and sodium concentrations. These differing effects of the two drugs are ascribed to differing routes of administration and volumes of distribution in body fluids. The 75-gm dose of each drug was well tolerated and effective in reducing intraocular pressure for a minimum of 90 minutes. This dose range appears optimal for clinical testing.
The Design of a Study to Analyze the Influence of Texting while Driving

We examine the influence of texting while driving to determine if there are driving impairments. Three participants took part in a pilot study in which they drove as normal for a few minutes and drove while texting for the same amount of time. The results indicate that texting leads to a reduction in speed and impaired participants ability to maintain a safe lane position while driving. ACM Classification: H5.2 [Information interfaces and presentation]: User Interfaces. Graphical user interfaces. General terms: Human Factors
A GA-Based X-Filling for Reducing Launch Switching Activity toward Specific Objectives in At-Speed Scan Testing

Power-aware X-filling is a preferable approach to avoiding IR-drop-induced yield loss in at-speed scan testing. However, the ability of previous X-filling methods to reduce launch switching activity may be unsatisfactory, due to low effect (insufficient and global-only reduction) and/or low scalability (long CPU time). This paper addresses this reduction quality problem with a novel GA (Genetic Algorithm) based X-filling method, called GA-fill. Its goals are (1) to achieve both effectiveness and scalability in a more balanced manner and (2) to make the reduction effect of launch switching activity more concentrated on critical areas that have higher impact on IR-drop-induced yield loss. Evaluation experiments are being conducted on both benchmark and industrial circuits, and the results have demonstrated the usefulness of GA-fill.
Shopping Centres and the Price of Proximate Residential Properties

The paper investigates the relationship between shopping centres (as a whole) and the price of neighbouring residential properties as well as the relative advantage(s), in terms of proximity factor effect, of a modern shopping mall and a conventional town centre. It is found, through hedonic analysis of 8600 transactions from 19 public housing estates, that proximity to shopping centres generally commands a premium. Notwithstanding the negative externalities of shopping centres, residential properties within 100-metre radius of shopping centres command a higher premium than those farther away although the price-distance relationship is not monotonic while the proximity factor varies from housing estate to housing estate. Furthermore, the results of the study show that residential properties near a town centre with a shopping mall command a higher premium than those near a town centre without a shopping mall. These findings will be of interest to investors in public housing and policy makers.
Comparative analysis of the biological components of pomegranate seed from different cultivars

ABSTRACT Three pomegranate clutivars (Tunisia soft seed, Taishanhong, and Qingpiruanzi) were used to evaluate their seed germination percentage, potential, germination time, and shoot growth indices along with antioxidant capacity, bioactive components (i.e., oil, crude fat, soluble sugar, protein, total phenolic and flavonoid, and Vitamin C (VC) content, and mineral element contents of their seeds and sprouts). ‘Tunisia soft seed’ exhibited the highest germination percentage (86.33%) and potential (39.33%) while ‘Qingpiruanzi’ had the shortest germination time (15d) and lowest rate (23.33%). Soluble sugar content of sprouts (16.93–25.81 mg/g) was 1–2-folds that of seeds (8.29–14.06 mg/g). The soluble protein content of seeds (102.05–161.37 mg/g) was 10-fold higher than that of sprouts (14.71–21.46 mg/g), while the VC content of sprout (29.11–32.83 mg/100g) was more than 10 times higher than that of seed (1.89–3.25 mg/100g). Oil content of three varieties's seeds ranged from 164.44 to 183.52 mg/g. Pomegranate seed oil contains 14 fatty acids, the most abundant of which is punicic acid (71.85–77.78%). Pomegranate seeds and sprouts are also rich in mineral elements (calcium 99.49–238.25 mg/100g) and magnesium (97.41–187.59 mg/100g). Total phenols (14.68–16.29 mg/g) and flavonoids (1.97–2.48 mg/g) content in sprouts were significantly higher than that of seeds (3.88–4.96 and 0.51–0.68 mg/g). Antioxidant capacity detected by ABTS and DPPH, FRAP assay was positively associated with total phenolic (ABTS: r = 0.946, DPPH: r = 0.977, FRAP: r = 0.985). These preliminary results were essential to investigate the possibilities of commercial natural health food utilization of pomegranate products in China.
Prognostic Value of Vascular Endothelial Growth Factor Expression in Patients with Esophageal Cancer: A Systematic Review and Meta-analysis

Background: VEGF is a prime mediator of tumorigenesis and metastasis. Various studies assessing the prognostic value of VEGF in patients with esophageal cancer remain controversial. This study aims to comprehensively and quantitatively summarize the evidence on the suitability of VEGF to predict patients' survival. Methods: Searches were applied to PubMed and EMBASE until December 31, 2011, without language restrictions. Studies were assessed for quality using REMARK (Reporting recommendations for tumor MARKer prognostic studies). Data were collected comparing overall survival in patients with high VEGF level with those with low level. We conducted a systematic review of 31 studies (n = 2,387 patients) and completed a meta-analysis of 30 studies (n = 2,345 patients) that correlated VEGF levels with overall survival. Data were synthesized with HRs. Results: The estimated risk of death was 1.82-fold greater in patients with high VEGF expression [95% confidence interval (CI), 1.58–2.08]. The heterogeneity was not significant (P = 0.130) between studies. High VEGF expression was associated with worse survival in esophageal squamous cell carcinoma (HR, 1.81; 95% CI, 1.57–2.10) and there was no significance in between-study heterogeneity (P = 0.185). Data collected were not sufficient to determine the prognostic value of VEGF in patients with esophageal adenocarcinoma. Conclusions: In this meta-analysis, elevated VEGF expression was associated with poor survival in patients with esophageal cancer but not esophageal adenocarcinoma. Impact: These results support further investigation of VEGF expression for predicting poor survival in patients with esophageal carcinoma and may have implications for treatments directed at inhibiting VEGF-mediated angiogenesis. Cancer Epidemiol Biomarkers Prev; 21(7); 1126–34. ©2012 AACR.
O PORTUGUÊS COMO LÍNGUA DE ACOLHIMENTO E INTERAÇÃO: A BUSCA PELA AUTONOMIA POR PESSOAS EM SITUAÇÃO DE REFÚGIO NO BRASIL

ste trabalho apresenta uma pequena investigacao sobre o Portugues como Lingua de Acolhimento (PLAc) e sua importância para as pessoas em situacao de refugio. Procuramos tracar um perfil do refugiado no Brasil e trazer alguns dados sobre os cursos de PLAc na cidade de Sao Paulo. Ao mesmo tempo, procuramos evidenciar a importância do aprendizado do portugues no processo de integracao e interacao.
Microwave quantum optics with an artificial atom in one-dimensional open space

We address recent advances in microwave quantum optics with artificial atoms in one-dimensional (1D) open space. This field relies on the fact that the coupling between a superconducting artificial atom and propagating microwave photons in a 1D open transmission line can be made strong enough to observe quantum coherent effects, without using any cavity to confine the microwave photons. We investigate the scattering properties in such a system with resonant coherent microwaves. We observe the strong nonlinearity of the artificial atom and under strong driving we observe the Mollow triplet. By applying two resonant tones, we also observe the Autler–Townes splitting. Exploiting these effects, we demonstrate two quantum devices at the single-photon level in the microwave regime: the single-photon router and the photon-number filter. These devices provide important steps toward the realization of an on-chip quantum network.
Loop transfer recovery via a proportional-integral observer

A systematic loop transfer recovery (LTR) design procedure based on a proportional-integral (PI) observer is described. In this method the robustness of the optimal regulator is recovered perfectly in the sense that the loop transfer characteristic of the optimal regulator is recovered for all values of a complex variable. An important advantage over previous LTR techniques is that the solution for observer design parameters is found from an underdetermined system of linear equations having two degrees of freedom (in the single-output case). This freedom can be used to shape the response, thereby eliminating the need to improve response properties via model-following techniques. A design example is given to illustrate the method