Miracle-dz/UniFAR-FTUs huggingface dataset:
zCap: a zero configuration adaptive paging and mobility management mechanism

Today, cellular networks rely on fixed collections of cells (tracking areas) for user equipment localisation. Locating users within these areas involves broadcast search (paging), which consumes radio bandwidth but reduces the user equipment signalling required for mobility management. Tracking areas are today manually configured, hard to adapt to local mobility and influence the load on several key resources in the network. We propose a decentralised and self‐adaptive approach to mobility management based on a probabilistic model of local mobility. By estimating the parameters of this model from observations of user mobility collected online, we obtain a dynamic model from which we construct local neighbourhoods of cells where we are most likely to locate user equipment. We propose to replace the static tracking areas of current systems with neighbourhoods local to each cell. The model is also used to derive a multi‐phase paging scheme, where the division of neighbourhood cells into consecutive phases balances response times and paging cost. The complete mechanism requires no manual tracking area configuration and performs localisation efficiently in terms of signalling and response times. Detailed simulations show that significant potential gains in localisation efficiency are possible while eliminating manual configuration of mobility management parameters. Variants of the proposal can be implemented within current (LTE) standards. Copyright © 2013 John Wiley & Sons, Ltd.
Central amygdala Fos expression during hypotensive or febrile, nonhypotensive endotoxemia in conscious rats

The distribution and time course of Fos expression in neurons in the central nucleus of the amygdala (CeA) were studied in endotoxemic rats in two separate experiments. In each case, the severity of the endotoxin (lipopolysaccharide; LPS) challenge was characterized by using physiological outcome variables, including blood pressure and heart rate. Throughout the rostrocaudal extent of the CeA, extensive Fos staining was found 3 hours after injection with a hypotensive dose of Salmonella enteritidis LPS. Hypotension alone has been reported to induce Fos in the CeA; therefore, the remaining experiments were performed by using a lower dose of Escherichia coli LPS that did not cause hypotension. The nonhypotensive dose of E. coli LPS also induced Fos in large numbers of neurons of the CeA, with peak staining at 2 hours and Fos staining persisting for 6 hours after LPS injection. Tachycardia and fever after LPS also persisted for at least 6 hours. CeA Fos staining during nonhypotensive endotoxemia was predominantly located in the lateral subnucleus, although Fos‐stained medial subnucleus neurons were also present. Additional forebrain regions that showed persistent Fos staining 6 hours after LPS included the parvocellular paraventricular nucleus of the hypothalamus, the bed nucleus of the stria terminalis, and the medial preoptic area. Forebrain regions that contained Fos‐stained nuclei at earlier time points, but not at 6 hours, included the supraoptic nucleus, magnocellular regions of the paraventricular nucleus of the hypothalamus, the subfornical organ, and the organum vasculosum of the lamina terminalis. Few CeA neurons showed Fos staining in rats that were restrained in a ventilated plastic tube. Neurons in the lateral septal nucleus and the medial amygdaloid nucleus, which have numerous Fos‐stained nuclei after stressors such as footshock or restraint, did not show Fos staining above control levels after LPS administration. Activation of CeA neurons after intravenous LPS may indicate persistent drive from vagal afferents and may implicate the CeA in the autonomic, neuroendocrine, and/or behavioral responses to this treatment. J. Comp. Neurol. 379:592–602, 1997. © 1997 Wiley‐Liss, Inc.
Does Herpes Virus Reactivation Affect Prognosis in Idiopathic Sudden Sensorineural Hearing Loss?

Objectives Several etiologies have been proposed to underlie idiopathic sudden sensorineural hearing loss (ISSNHL), including viral infection, vascular disturbance, and immune-mediated mechanisms. However, none of these mechanisms are conclusive. Should ISSNHL be caused by reactivation of a viral infection, antiviral treatment would be an important option. Thus, in this study, we reported the prognosis according to serologic test results of herpes viruses in patients with ISSNHL. We also evaluated treatment response with acyclovir and corticosteroids versus corticosteroids alone in herpes simplex virus (HSV) seropositive ISSNHL patients. Methods We compared hematologic examinations and the results of audiometry testing in 232 patients with ISSNHL. Statistical analyses for initial hearing impairment, progression of hearing impairment, recovery of hearing loss, and laboratory results were performed in all patients. All statistical analyses were performed using SPSS software. Results The 232 ISSNHL patients were divided into two subgroups according to HSV immunoglobulin M (IgM) serologic results (seropositive or seronegative). When the seropositive group was compared to the seronegative group, age, gender, body mass index (BMI), white blood cell, absolute neutrophil count, absolute monocyte count, and platelet count were not significantly different. Initial hearing level, final recovery hearing level, and recovery time were also not significantly different between the two groups (P>0.05). Though there were no significant differences in age, gender, BMI, or viral HSV IgM titer, the two groups had similar initial hearing level, final recovery hearing level, and recovery time. The difference in hearing threshold before and after treatment was larger (18.7±37.1) in the group receiving antiviral medication than in the corticosteroids group (11.0±44.5), but this difference was not significant (P=0.619). Conclusion There was no significant difference of prognosis between the patients with and without reactivation of HSV. In addition, there seems to be no benefit for the treatment of acyclovir combined with the corticosteroids in the patients with ISSNHL.
Designing Molecular Dynamics Simulations to Shift Populations of the Conformational States of Calmodulin

We elucidate the mechanisms that lead to population shifts in the conformational states of calcium-loaded calmodulin (Ca2+-CaM). We design extensive molecular dynamics simulations to classify the effects that are responsible for adopting occupied conformations available in the ensemble of NMR structures. Electrostatic interactions amongst the different regions of the protein and with its vicinal water are herein mediated by lowering the ionic strength or the pH. Amino acid E31, which is one of the few charged residues whose ionization state is highly sensitive to pH differences in the physiological range, proves to be distinctive in its control of population shifts. E31A mutation at low ionic strength results in a distinct change from an extended to a compact Ca2+-CaM conformation within tens of nanoseconds, that otherwise occur on the time scales of microseconds. The kinked linker found in this particular compact form is observed in many of the target-bound forms of Ca2+-CaM, increasing the binding affinity. This mutation is unique in controlling C-lobe dynamics by affecting the fluctuations between the EF-hand motif helices. We also monitor the effect of the ionic strength on the conformational multiplicity of Ca2+-CaM. By lowering the ionic strength, the tendency of nonspecific anions in water to accumulate near the protein surface increases, especially in the vicinity of the linker. The change in the distribution of ions in the vicinal layer of water allows N- and C- lobes to span a wide variety of relative orientations that are otherwise not observed at physiological ionic strength. E31 protonation restores the conformations associated with physiological environmental conditions even at low ionic strength.
Relationship closeness on behavioral traits

The purpose of this study was to examine the aspect of closeness that the Relationship Closeness Inventory (Berscheid et al. 1989: RCI) measures. Four hundred undergraduate students (177 male and 223 female) identified the one person whom they considered to be close. And then they completed a questionnaire about that relationship including questions on six behavioral traits. Principal component analyses of six behavioral traits were conducted for four conditions-male friendship, female friendship, male romantic relationship, and female romantic relationship. The results showed that several princial components were observed in all conditions. Especially, present progressive component was observed in all conditions and stable component in three of the four conditions. Correlations between RCI score and each component score showed that RCI score was highly correlated with present progressive component, but had almost no correlation with the other components. Based on the results, the validity and limitation of the RCI was discussed.
Processing of proprioceptive and vestibular body signals and self-transcendence in Ashtanga yoga practitioners

In the rod and frame test (RFT), participants are asked to set a tilted visual linear marker (i.e., a rod), embedded in a square, to the subjective vertical, irrespective of the surrounding frame. People not influenced by the frame tilt are defined as field-independent, while people biased in their rod verticality perception are field-dependent. Performing RFT requires the integration of proprioceptive, vestibular and visual signals with the latter accounting for field-dependency. Studies indicate that motor experts in body-related, balance-improving disciplines tend to be field-independent, i.e., better at verticality perception, suggesting that proprioceptive and vestibular expertise acquired by such exercise may weaken the influence of irrelevant visual signals. What remains unknown is whether the effect of body-related expertise in weighting perceptual information might also be mediated by personality traits, in particular those indexing self-focusing abilities. To explore this issue, we tested field-dependency in a class of body experts, namely yoga practitioners and in non-expert participants. Moreover we explored any link between performance on RFT and self-transcendence (ST), a complex personality construct, which refers to tendency to experience spiritual feelings and ideas. As expected, yoga practitioners (i) were more accurate in assessing the rod's verticality on the RFT, and (ii) expressed significantly higher ST. Interestingly, the performance in these two tests was negatively correlated. More specifically, when asked to provide verticality judgments, highly self-transcendent yoga practitioners were significantly less influenced by a misleading visual context. Our results suggest that being highly self-transcendent may enable yoga practitioners to optimize verticality judgment tasks by relying more on internal (vestibular and proprioceptive) signals coming from their own body, rather than on exteroceptive, visual cues.
Fast byzantine agreement in dynamic networks

We study Byzantine agreement in dynamic networks where topology can change from round to round and nodes can also experience heavy churn (i.e., nodes can join and leave the network continuously over time). Our main contributions are randomized distributed algorithms that achieve almost-everywhere Byzantine agreement with high probability even under a large number of adaptively chosen Byzantine nodes and continuous adversarial churn in a number of rounds that is polylogarithmic in n (where n is the stable network size). We show that our algorithms are essentially optimal (up to polylogarithmic factors) with respect to the amount of Byzantine nodes and churn rate that they can tolerate by showing a lower bound. In particular, we present the following results: 1. An O(log3 n) round randomized algorithmto achieve almost everywhere Byzantine agreement with high probability under a presence of up to O(√n/polylog(n)) Byzantine nodes and up to a churn of O(√n/polylog(n)) nodes per round. We assume that the Byzantine nodes have knowledge about the entire state of network at every round (including random choices made by all the nodes) and can behave arbitrarily. We also assume that an adversary controls the churn - it has complete knowledge and control of what nodes join and leave and at what time and has unlimited computational power (but is oblivious to the topology changes from round to round). Our algorithm requires only polylogarithmic in n bits to be processed and sent (per round) by each node. 2. We also present an O(log3 n) round randomized algorithm that has same guarantees as the above algorithm, but works even when the connectivity of the network is controlled by an adaptive adversary (that can choose the topology based on the current states of the nodes). However, this algorithm requires up to polynomial in n bits to be processed and sent (per round) by each node. 3. We show that the above bounds are essentially the best possible, if one wants fast (i.e., polylogarithmic run time) algorithms, by showing that any (randomized) algorithm to achieve agreement in a dynamic network controlled by an adversary that can churn up to Θ(√n log n) nodes per round should take at least a polynomial number of rounds. Our algorithms are the first-known, fully distributed, Byzantine agreement algorithms in highly dynamic networks. We view our results as a step towards understanding the possibilities and limitations of highly dynamic networks that are subject to malicious behavior by a large number of nodes.
Generation Conservation: Children’s Developing Folkbiological and Moral Conceptions of Protecting Endangered Species

ABSTRACT Research Findings: This study investigated folkbiological concepts that structure children’s moral reasoning regarding conservation. Participants (N = 52; 7- and 10-year-olds, gender balanced) were interviewed regarding their values, moral obligations, and rights concerns for endangered and extinct animals. Across the 2 ages, children drew on the animal’s living status and teleology, as well as ecological relations, to ground their moral reasoning. Developmentally speaking, the younger children employed both nature-centered and human-centered moral reasoning, whereas the older children employed a complex form of moral reasoning that integrated human models of moral thinking with distinct biological understanding. Practice or Policy: The findings can improve education and policy that supports the next generation of conservationists. Educators can draw on these findings to develop class material and activities that teach children about ecological relations—knowledge children can employ to construct their moral arguments for conservation and protecting the environment. The findings revealed that children think about and value endangered animals in deep and beautiful ways. Policymakers can draw on the findings to frame their decision making—drawing more deeply on children’s values of the natural world to inform policy decisions. Drawing on children’s values in the development of environmental policy engages them in the policy process.
A Theory of Rule Development

This article develops a model with endogenously coarse rules. A principal hires an agent to take an action. The principal knows the optimal state-contingent action, but cannot communicate it perfectly due to communication constraints. The principal can use previously realized states as examples to define rules of varying breadth. We analyze how rules are chosen under several assumptions about how rules can be amended. We explore the inefficiencies that arise and how they depend on the ability to refine rules, the principal’s time horizon and patience, and other factors. Our model exhibits path dependence in that the efficacy of rule development depends on the sequence of realizations of the state. We interpret this as providing a foundation for persistent performance differences between similar organizations and explore the role of different delegation structures in ameliorating the effects of bounded communication. (JEL D23, K40, D83)
Angular dependent optical wavelength selection in hybrid cavity-channel structure by coupled plasmon resonance

We propose a hybrid cavity-channel structure to tune optical wavelengths using narrow-band resonances. High spectral selectivity and high angular dependency of the absorptance are reported due to the resonance between propagating surface plasmon modes and channel modes. By varying the incident angle, we could adjust both the position and the amplitude of the reflectance dips thus achieving highly efficient angular optical switches.
Comb-wax discrimination by honeybees tested with the proboscis extension reflex.

We used the proboscis extension reflex of honeybees to test their ability to discriminate between comb waxes of different ages (wax scales, 1-week-old wax, 2- to 3-year-old wax, 8- to 10-year-old wax). Such waxes differ in their chemical composition, and an ability to discriminate between them may aid the orientation of the bees in the nest. To train the bees, we used whole extracts of waxes and four different fractions of the whole extract based on different elutions of solid-phase extractions (extract I, fraction A eluted with hexane and fraction B with diethylether; extract II, fraction B further subdivided into fraction C by elution with isopropylchloride and fraction D by elution with diethylether). In a differential training regime (six learning and six test trials) with whole extracts or with the different fractions, we paired one type of wax with a reward and another with no reward. The bees learned to discriminate between all tested pairs of whole extracts. The two subfractions (fractions A and B) gave different results: the bees could discriminate between waxes of different ages when fraction B was used but not when fraction A was used. A further subdivision of fraction B into fractions C and D showed that only fraction D contained the elements that enabled bees to discriminate between old and new wax. Fraction D makes up only 5? 8 % of the total wax mass and contains hydroxy alkyl esters (5? 6 % of the total wax mass), primary alcohols (0.3? 0.5 % of the total wax mass) and acids (0.06? 1. 0 % of the total wax mass). Fractions A and C (together forming 62? 64 % of the total wax mass), which consist of unbranched and branched aliphatic hydrocarbons and alkyl esters, could not be discriminated by the bees. The remaining wax mass (25? 29 %) was eluted with a mixture of chloroform, methanol and water (13:5:1) as fraction E.
Identification of minor metabolites of phospholipid signal molecules in [ 32 P]P i -labelled platelets

Incubation of blood platelets with 32 P-labelled inorganic phosphate for 60 min leads to incorporation of radioisotope mainly into phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidyl-4,5-bisphosphate (PIP 2 ) in resting platelets and into phosphatidic acid (PA) in activated platelets. Small amounts of other important phosphoinositide isomers also become labelled following platelet activation, among them the 3-phosphorylated derivatives. In addition, several other faintly labelled spots are visible on TLC separations. Three of these lipids have now been identified as lysophosphatidylinositol (lysoPI), lysophosphatidic acid (lysoPA) and CDP-diacylglcerol (CDP-DAG). [ 32 P]LysoPI was present in resting and activated platelets, whereas [ 32 P]lysoPA and [ 32 P]CDP-DAG were observed only upon platelet activation. The phosphoinositide cycle turns over without accumulation of [ 32 P]PA and [ 32 P]CDP-DAG in resting platelets. A large increase (as much as 40-fold) in the steady-state level of [ 32 P]PA is seen in thrombin-activated platelets. A slight increase in the steady-state levels of [ 32 P]CDP-DAG is accompanied by a similar increase in [ 32 P]PI and larger increases in [ 32 P]PIP and [ 32 P]PIP 2 (about 50%), which is indicative of a general increase in flux in the PPI cycle. Elevation of CDP-DAG levels is probably only a reflection of increased flux, whereas lysoPA and lysoPI have been reported to have diverse signalling functions in various cells.
Colleague guanxi intensity: Scale development and validation

Abstract This research reviews the constructs and measurements of guanxi and concludes that colleague guanxi is appropriately conceptualized as a multidimensional construct that describes Chinese colleague relationships. The development of a colleague guanxi scale with four dimensions is described. Two studies test the convergent, discriminant, and nomological validity of the guanxi scale. In validation tests guanxi intensity increases with cognition features (subjective fit and cognitive trust) and results in a positive affect (affective trust). Contributions of the colleague guanxi scale are offered.
Clonal integration and expression of human T‐cell lymphotropic virus type I in carriers detected by polymerase chain reaction and inverse PCR

Adult T‐cell leukemia (ATL) is a neoplasm of mature helper (CD4) T lymphocytes, and human T‐cell lymphotropic virus type‐I (HTLV‐I) has been suggested to be the causative virus of ATL. HTLV‐I integrates its proviruses into random sites in host chromosomal DNA. Clonal integration has been observed in patients with ATL, including smoldering, chronic, and acute states. However, random and/or polyclonal integration has only been reported in a few asymptomatic HTLV‐I carriers. To clarify the clonality of HTLV‐I‐infected cells in carriers, we used an inverse polymerase chain reaction (IPCR), which is more sensitive than Southern blot analysis. We used the peripheral blood momonuclear cells (PBMC) from 16 asymptomatic carriers and the separated CD4‐positive cells. No cases showed either a monoclonal or polyclonal integration of the HTLV‐I provirus by Southern blot. But, using IPCR, 7 of 16 cases showed either mono‐ or oligoclonal integration. In addition, the populations of clonal provirus in the total PBMC were frequently different from those in the CD4‐positive cells. Three cases showed expression of HTLV‐I tax/rex mRNA in the total PBMC, but no such expression was found in CD4‐positive cells. In this study, an unexpected frequency of clonal HTLV‐I provirus DNA was observed in HTLV‐I carriers. These findings indicate that the clonal but nonmalignant proliferation of HTLV‐I‐infected cells already occurs even in HTLV‐I carriers, and therefore that some other step is necessary to induce malignant proliferation. Am. J. Hemato. 54:306–312, 1997. © 1997 Wiley‐Liss, Inc.