Miracle-dz/UniFAR-FTUs huggingface dataset:
Association between phase angle, anthropometric measurements, and lipid profile in HCV-infected patients

OBJECTIVE: The objective of this study was to investigate the associations between phase angle, anthropometric measurements, and lipid profile in patients chronically infected with the hepatitis C virus. METHODS: A total of 160 consecutive patients chronically infected with the hepatitis C virus and who received treatment at the hepatitis C outpatient unit of our hospital from April 2010 to May 2011 were prospectively evaluated. Bioelectrical impedance analysis, anthropometric measurements, and serum lipid profile analysis were performed. RESULTS: Twenty-five patients were excluded. A total of 135 patients with a mean age of 49.8±11.4 years were studied. Among these patients, 60% were male. The phase angle and BMI means were 6.5±0.8° and 26.5±4.8 kg/m2, respectively. Regarding anthropometric variables, mid-arm circumference, mid-arm muscle circumference, and arm muscle area had a positive correlation with phase angle. In contrast, when analyzing the lipid profile, only HDL was inversely correlated with phase angle. However, in multiple regression models adjusted for age and gender, only mid-arm circumference (p = 0.005), mid-arm muscle circumference (p = 0.003), and arm muscle circumference (p = 0.001) were associated with phase angle in hepatitis C virus-infected patients. CONCLUSIONS: In conclusion, phase angle is positively correlated with anthropometric measures in our study. However, there is no association between phase angle and lipid profile in these patients. Our results suggest that phase angle is related to lean body mass in patients chronically infected with hepatitis C virus.
Plasmodium infection decreases fecundity and increases survival of mosquitoes

Long-lived mosquitoes maximize the chances of Plasmodium transmission. Yet, in spite of decades of research, the effect of Plasmodium parasites on mosquito longevity remains highly controversial. On the one hand, many studies report shorter lifespans in infected mosquitoes. On the other hand, parallel (but separate) studies show that Plasmodium reduces fecundity and imply that this is an adaptive strategy of the parasite aimed at redirecting resources towards longevity. No study till date has, however, investigated fecundity and longevity in the same individuals to see whether this prediction holds. In this study, we follow for both fecundity and longevity in Plasmodium-infected and uninfected mosquitoes using a novel, albeit natural, experimental system. We also explore whether the genetic variations that arise through the evolution of insecticide resistance modulate the effect of Plasmodium on these two life-history traits. We show that (i) a reduction in fecundity in Plasmodium-infected mosquitoes is accompanied by an increase in longevity; (ii) this increase in longevity arises through a trade-off between reproduction and survival; and (iii) in insecticide-resistant mosquitoes, the slope of this trade-off is steeper when the mosquito is infected by Plasmodium (cost of insecticide resistance).
How usual is treatment as usual? Experienced therapists’ reflections on participation in practice-based research

Abstract Studies have shown that many clinicians are skeptical about research and hesitant about participating in research. In the present study, we explored this issue by studying experienced therapists’ reflections on their participation in practice-based research. Data were drawn from a practice-based research study at the University of Oslo, Norway. Twelve highly experienced therapists who had contributed to the study were invited to complete an open-ended questionnaire regarding their participation, and the text material was analyzed using a thematic analytic approach. Results indicated that research participation was experienced both as beneficial and demanding, and that being observed by others and following research procedures was experienced as affecting therapists’ clinical work. We discuss these findings in relation to the distinction between “treatment as usual” versus “treatment in a research context”, and offer suggestions for steps to increase the clinical relevance and the ecological validity of psychotherapy research.
Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon

Vascular smooth muscle (VSM) is unique in its ability to maintain an intrinsic level of contractile force, known as tone. Vascular tone is believed to arise from the constitutive activity of membrane-bound L-type Ca2+ channels (LTCC). This study used a pharmacological agonist of LTCC, Bay K8644, to elicit a sustained, sub-maximal contraction in VSM that mimics tone. Downstream signaling was investigated in order to determine what molecules are responsible for tone. Medial strips of swine carotid artery were stimulated with 100 nM Bay K8644 to induce a sustained level of force. Force and phosphorylation levels of myosin light chain (MLC), MAP kinase, MYPT1, CPI-17, and caldesmon were measured during Bay K8644 stimulation in the presence and absence of nifedipine, ML-7, U0126, bisindolylmaleimide (Bis), and H-1152. Nifedipine and ML-7 inhibited force and MLC phosphorylation in response to Bay K8644. Inhibition of Rho kinase (H-1152) but not PKC (Bis) inhibited Bay K8644 induced force. U0126 significantly increased Bay K8644-dependent force with no effect on MLC phosphorylation. Neither CPI-17 nor caldesmon phosphorylation were increased during the maintenance of sustained force. Our results suggest that force due to the influx of calcium through LTCCs is partially MLC phosphorylation-dependent but does not involve PKC or caldesmon. Interestingly, inhibition of MLC kinase (MLCK) and PKC significantly increased MAP kinase phosphorylation suggesting that MLCK and PKC may directly or indirectly inhibit MAP kinase activity during prolonged contractions induced by Bay K8544.
Inconsistent Sodium Current Records Derived on Ranvier Nodes with a Commercially Available Potential Clamp Device According to

We tried to reproduce some basic implications of the HodgkinHuxley-Frankenhaeuser formalism by measuring sodium currents in single myelinated nerve fibres with a commercially available version of the potential clamp device according to Nonner. The following contradictory observations were made: 1. The potential dependence of the time to peak sodium currents showed a discontinuity around the sodium equilibrium potential. 2. Defining the sodium permeability PNa by the constant field equation and fitting the peak PNa-voltage relation by a sigmoid function we obtained unbelievable high values of /Na at rest. 3. Testing PNd as calculated by the constant field equation by so-called "sodium tail current" experiments we obtained instantaneous changes of PNa. Summing up, neither the kinetics of sodium currents nor the constant field concept as tested with the equipment used seem to agree satisfactorily with the standard data of sodium currents in Ranvier nodes.
Survey on Security Requirements and Models for Group Key Exchange

In this report we provide an analytical survey on security issues that are relevant for group key exchange (GKE) protocols. We start with the description of the security requirements that have been informally described in the literature and widely used to analyze security of earlier GKE protocols. Most of these definitions were originally stated for two-party protocols and then adapted to a group setting. These informal definitions are foundational for the later appeared formal security models for GKE protocols whose development, strengths, and weaknesses are also described and analyzed.
Continuity and change in the institution of town and country planning: Modelling the role of ideology

The institution of town and country planning rests upon ideas and concepts which will always be contested. Such concepts include ‘liberty’, ‘community’, ‘society’ and ‘the state’. It is a function of political ideology to seek to fix the meanings of contested concepts and thus exert control over political reality. By analysing the particular conceptual structure of the ideologies which seek to influence planning from positions of political power, the analyst can show how these ideologies are related to shifts in the conceptual and institutional structure of planning. The article illustrates this analytical method in the context of the transition from the ideology of New Labour to the ideology of the Conservative-led Coalition government in England after 2010.
Information Theoretic Optimization of Audio Features for Multimodal Speaker Detection

We present a method that exploits the information theoretic framework described in [1] to extract optimal audio features with respect to the video features. A simple measure of mutual information between the resulting audio features and the video ones allows to detect the active speaker among dieren t candidates. The results show that our method is able to exploit the shared speech information contained in audio and video signals to recover their common source.
Improving Rare Case Prediction with Replication Technique

The ability to predict correctly rarely occurring cases is important to the success of applying data mining method to many real life applications. In the context of data mining, rare cases refer to labeled data instances that are infrequently occurred in the database. Discovering infrequent patterns are of interest in some specific domains such as genetic mutant identification, fraud credit card detection, network intruder prevention. But most learning algorithms are biased toward the majority cases such that the minority cases are considered as noise and thus they are ignored during the model induction steps. This ignorance causes the learning algorithm to generate a model that cannot classify or predict a minority case. We thus study the replication technique based on the over-sampling method to solve this problem. However, a straightforward application of oversampling method may lead to the over-fitting problem in such a way that the generated model is too specific to the manipulated data. We thus apply the cluster-based technique to selectively filter a training dataset. The experimental results on primary tumor, arrhythmia and communities-and-crime datasets show significant improvement on predicting accuracy, specificity, and sensitivity of the induced models. But the results on multiple features correlation dataset show non-significant improvement; this case requires further investigation.
Claudin-1 Binder Enhances Epidermal Permeability in a Human Keratinocyte Model

Tight junctions (TJs) are complex biochemical structures that seal the intercellular space and prevent the free movement of solutes across epithelial cell sheets. Modulating the TJ seal is a promising option for increasing the transdermal absorption of drugs. Within TJs, the binding of the claudin (CLDN) family of tetratransmembrane proteins through cis- and trans-interactions is an integral part of seal formation. Because epidermal TJs contain CLDN-1 and CLDN-4, a binder for these CLDNs may be a useful modulator of the permeability of the epidermal barrier. Here, we investigated whether m19, which can bind to CLDN-1/-4 (also CLDN-2/-5), modulates the integrity of epidermal TJs and the permeability of cell sheets to solutes. Treatment of normal human epidermal keratinocytes (NHEKs) with the CLDN binder reduced the integrity of TJs. A CLDN-1–specific binder (a monoclonal antibody, clone 7A5) also weakened the TJ seal in NHEKs. Although m19 attenuated the TJ barrier in human intestinal epithelial cells (Caco-2), 7A5 did not. Treatment of NHEKs with 7A5 enhanced permeation of a paracellular permeation marker. These findings indicate that CLDN-1 is a potential target for modulating the permeability of the epidermis, and that our CLDN-1 binder is a promising candidate molecule for development as a dermal absorption enhancer.
A systemic point-cloud de-noising and smoothing method for 3D shape reuse

3D shape reuse, as an effective way to carry out innovative design, requires a digital model database where the entities are accurate and sufficient representations of objects in the real world. 3D scanning is a prevailing tool to quickly convert physical models into virtual ones. However, the scanned models without post-processing could not be used directly due to environment noise and accuracy limitation in terms of discrete sampling property in scanning. This paper introduces a systemic point-cloud de-noising and mesh smoothing method to handle this issue. The model de-noising and regularity is based on k-means clustering, and mesh smoothing module is an improved mean approach which processes the discrete data in the regular order. Case study will be given to verify the smoothing effectiveness. The proposed method could facilitate the construction of model database for design reuse, and could be output to downstream applications such as shape adaptive deformation, and shape searching.
Capacity and error exponent for the direct detection photon channel-Part I

The capacity and error exponent of the direct detection optical channel are considered. The channel input in a T-second interval is a waveform A(r), 0 5 t I T, which satisfies 0 I A(t) I A, and (l/r)],,%(t) dt I aA, 0 < IT 11. The channel output is a Poisson process with intensity parameter X(t) + he. ‘The quantities A and CIA represent the peak and average power, respectively, of the optical signal, and X0 represents the “dark current. ” In Part I the channel capacity of this channel and a lower bound on the error exponent are calculated. An explicit construction for an exponentially opt imum family of codes is also exhibited. In Part II we obtain an upper bound on the error exponent which coincides with the lower bound. Thus this channel is one of the very few for which the error exponent is known exactly. DEDICATION These papers are dedicated to the memory of Stephen 0. Rice, an extraordinary mentor, supervisor, and friend. He was a master of numerical methods and asymptotics and was very much at home with the nineteenth-century menager ie of special functions. The generous and easy way in which he shared his genius with his col leagues is legendary, and I was fortunate to have been a beneficiary of his advice and expertise during the first decade of my career at Bell Laboratories. As did all of Steve’s colleagues, I learned much from this gentle and talented man. We will remember him always.
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Wnt5a Suppresses Tumor Formation and Redirects Tumor Phenotype in MMTV-Wnt1 Tumors

Wnt5a is a non-canonical signaling Wnt that has been implicated in tumor suppression. We previously showed that loss of Wnt5a in MMTV-PyVmT tumors resulted in a switch in tumor phenotype resulting in tumors with increased basal phenotype and high Wnt/β-catenin signaling. The object of this study was to test the hypothesis that Wnt5a can act to inhibit tumors formed by activation of Wnt/β-catenin signaling. To this end, we characterized tumor and non-tumor mammary tissue from MMTV-Wnt1 and double transgenic MMTV-Wnt1;MMTV-Wnt5a mice. Wnt5a containing mice demonstrated fewer tumors with increased latency when compared to MMTV-Wnt1 controls. Expression of markers for basal-like tumors was down-regulated in the tumors that formed in the presence of Wnt5a indicating a phenotypic switch. Reduced canonical Wnt signaling was detected in double transgenic tumors as a decrease in active β-catenin protein and a decrease in Axin2 mRNA transcript levels. In non-tumor tissues, over-expression of Wnt5a in MMTV-Wnt1 mammary glands resulted in attenuation of phenotypes normally observed in MMTV-Wnt1 glands including hyperbranching and increased progenitor and basal cell populations. Even though Wnt5a could antagonize Wnt/β-catenin signaling in primary mammary epithelial cells in culture, reduced Wnt/β-catenin signaling was not detected in non-tumor MMTV-Wnt1;Wnt5a tissue in vivo. The data demonstrate that Wnt5a suppresses tumor formation and promotes a phenotypic shift in MMTV-Wnt1 tumors.
Annotating data selection for improving machine translation

In order to efficiently improve machine translation systems, we propose a method which selects data to be annotated (manually translated) from speech-to-speech translation field data. For the selection experiments, we used data from field experiments conducted during the 2009 fiscal year in five areas of Japan. For the selection experiments, we used data sets from two areas: one data set giving the lowest baseline speech translation performance for its test set, and another data set giving the highest. In the experiments, we compare two methods for selecting data to be manually translated from the field data. Both of them use source side language models for data selection, but in different manners. According to the experimental results, either or both of the methods show larger improvements compared to a random data selection.
New identified (3H)4d - (3H)4f transitions of Fe II from UVES spectra of HR 6000 and 46 Aql

The analysis of the high-resolution UVES spectra of the CP stars HR 6000 and 46 Aql revealed the presence of an impressive number of unidentified lines, in particular in the 5000 - 5400 A region. Because numerous 4d-4f transitions of FeII lie in this spectral range, and because both stars are iron overabundant, we investigated whether the unidentified lines can be due to FeII. ATLAS12 model atmospheres with parameters [13450K, 4.3] and [12560K, 3.8] were computed for the individual abundances of HR 6000 and 46 Aql, respectively, in order to use the stars as spectroscopic sources to identify FeII lines and to determine FeII gf-values. After having identified several unknown lines in the stellar spectra as due to (3H)4d - (3H)4f transitions of FeII, we derived stellar log gf's for them by comparing observed and computed profiles. The energies of the upper levels were assigned on the basis of both laboratory iron spectra and predicted energy levels. We fixed 21 new levels of FeII with energies between 122910.9 cm^-1 and 123441.1 cm^-1. They allowed us to add 1700 new lines to the Fe II line list in the range 810 - 15011 A.
Mechanisms of cognitive set flexibility in Parkinson's disease.

Previous research on cognitive set shifting in patients with Parkinson's disease has often been confounded by concept formation, rule learning, working memory and/or general slowing of cognitive processes. To circumvent this problem, the present study used the task-set switching procedure in which good performance was independent of rule learning, and in which working memory load was reduced by explicitly cueing the task switches. Our results provide strong evidence for a specific cognitive set shifting deficit in patients with mild Parkinson's disease in a non-learning context, which also cannot be explained by general slowing of cognitive processes. Moreover, the deficit was robust in a small sample of patients at the earliest stages of the disease. Finally, the impairment in task-set switching was only apparent when competing information was present, i.e. when the load on selection mechanisms was increased.
Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure

Background Metabolic impairment is an important contributor to heart failure (HF) pathogenesis and progression. Dysregulated metabolic pathways remain poorly characterized in patients with HF and preserved ejection fraction (HFpEF). We sought to determine metabolic abnormalities in HFpEF and identify pathways differentially altered in HFpEF versus HF with reduced ejection fraction (HFrEF). Methods and Results We identified HFpEF cases, HFrEF controls, and no‐HF controls from the CATHGEN study of sequential patients undergoing cardiac catheterization. HFpEF cases (N=282) were defined by left ventricular ejection fraction (LVEF) ≥45%, diastolic dysfunction grade ≥1, and history of HF; HFrEF controls (N=279) were defined similarly, except for having LVEF <45%. No‐HF controls (N=191) had LVEF ≥45%, normal diastolic function, and no HF diagnosis. Targeted mass spectrometry and enzymatic assays were used to quantify 63 metabolites in fasting plasma. Principal components analysis reduced the 63 metabolites to uncorrelated factors, which were compared across groups using ANCOVA. In basic and fully adjusted models, long‐chain acylcarnitine factor levels differed significantly across groups (P<0.0001) and were greater in HFrEF than HFpEF (P=0.0004), both of which were greater than no‐HF controls. We confirmed these findings in sensitivity analyses using stricter inclusion criteria, alternative LVEF thresholds, and adjustment for insulin resistance. Conclusions We identified novel circulating metabolites reflecting impaired or dysregulated fatty acid oxidation that are independently associated with HF and differentially elevated in HFpEF and HFrEF. These results elucidate a specific metabolic pathway in HF and suggest a shared metabolic mechanism in HF along the LVEF spectrum.
Longitudinal study of moderate weight change and sleep-disordered breathing.

CONTEXT Excess body weight is positively associated with sleep-disordered breathing (SDB), a prevalent condition in the US general population. No large study has been conducted of the longitudinal association between SDB and change in weight. OBJECTIVE To measure the independent longitudinal association between weight change and change in SDB severity. DESIGN Population-based, prospective cohort study conducted from July 1989 to January 2000. SETTING AND PARTICIPANTS Six hundred ninety randomly selected employed Wisconsin residents (mean age at baseline, 46 years; 56% male) who were evaluated twice at 4-year intervals for SDB. MAIN OUTCOME MEASURES Percentage change in the apnea-hypopnea index (AHI; apnea events + hypopnea events per hour of sleep) and odds of developing moderate-to-severe SDB (defined by an AHI > or =15 events per hour of sleep), with respect to change in weight. RESULTS Relative to stable weight, a 10% weight gain predicted an approximate 32% (95% confidence interval [CI], 20%-45%) increase in the AHI. A 10% weight loss predicted a 26% (95% CI, 18%-34%) decrease in the AHI. A 10% increase in weight predicted a 6-fold (95% CI, 2.2-17.0) increase in the odds of developing moderate-to-severe SDB. CONCLUSIONS Our data indicate that clinical and public health programs that result in even modest weight control are likely to be effective in managing SDB and reducing new occurrence of SDB.
Cytosolic splice isoform of Hsp70 nucleotide exchange factor Fes1 is required for the degradation of misfolded proteins in yeast

Yeast Hsp70 nucleotide exchange factor Fes1 is expressed by rare alternative splicing as two isoforms. Fes1L is targeted to the nucleus, and Fes1S localizes to the cytosol and is required for the efficient proteasomal degradation of cytosolic misfolded proteins, as well as of species that are imported into the nucleus for degradation.