Miracle-dz/UniFAR-FTUs huggingface dataset:
An optimal sampling approach to modelling whole-body vibration exposure in all-terrain vehicle driving

Abstract Exposure to whole-body vibration (WBV) presents an occupational health risk and several safety standards obligate to measure WBV. The high cost of direct measurements in large epidemiological studies raises the question of the optimal sampling for estimating WBV exposures given by a large variation in exposure levels in real worksites. This paper presents a new approach to addressing this problem. A daily exposure to WBV was recorded for 9–24 days among 48 all-terrain vehicle drivers. Four data-sets based on root mean squared recordings were obtained from the measurement. The data were modelled using semi-variogram with spectrum analysis and the optimal sampling scheme was derived. The optimum sampling period was 140 min apart. The result was verified and validated in terms of its accuracy and statistical power. Recordings of two to three hours are probably needed to get a sufficiently unbiased daily WBV exposure estimate in real worksites. The developed model is general enough that is applicable to other cumulative exposures or biosignals. Practitioner Summary: Exposure to whole-body vibration (WBV) presents an occupational health risk and safety standards obligate to measure WBV. However, direct measurements can be expensive. This paper presents a new approach to addressing this problem. The developed model is general enough that is applicable to other cumulative exposures or biosignals.
Analysis of muscle protein expression in polyethylene glycol-induced chicken: rat myoblast heterokaryons

Heterokaryons derived from polyethylene glycol-mediated fusion of myoblasts at different stages of development were used to investigate the transition of cells in the skeletal muscle lineage from the determined to the differentiated state. Heterokaryons were analyzed by immunofluorescence, using rabbit antibodies against the skeletal muscle isoforms of chicken creatine kinase and myosin, and a mouse monoclonal antibody that cross-reacts with chicken and rat skeletal muscle myosin. When cytochalasin B-treated rat L8(E63) myocytes (Konieczny S.F., J. McKay, and J. R. Coleman, 1982, Dev. Biol., 91:11-26) served as the differentiated parental component and chicken limb myoblasts from stage 23-26 or 10-12-d embryos were used as the determined, undifferentiated parental cell, heterokaryons exhibited a progressive extinction of rat skeletal muscle myosin during a 4-6-d culture period, and no precocious expression of chicken differentiated gene products was detected. In the reciprocal experiment, 85-97% of rat myoblast X chicken myocyte heterokaryons ceased expression of chicken skeletal muscle myosin and the M subunit of chicken creatine kinase within 7 d of culture. Extinction was not observed in heterokaryons produced by fusion of differentiated chicken and differentiated rat myocytes and thus is not due to species incompatibility or to the polyethylene glycol treatment itself. The results suggest that, when confronted in a common cytoplasm, the regulatory factors that maintain myoblasts in a proliferating, undifferentiated state are dominant over those that govern expression of differentiated gene products.
How Vaginal Infections Impact Women’s Everyday Life —Women’s Lived Experiences of Bacterial Vaginosis and Recurrent Vulvovaginal Candidiasis

Reoccurring symptoms and persistent problems that continue post treatment can be characteristic of the vaginal infections Bacterial Vaginosis (BV) and recurrent vulvovaginal candidiasis (RVVC). The purpose of this study was to describe women’s life experiences in managing the symptoms of bacterial vaginosis and Candida. Sixteen women were recruited and participated in an interview study when they contacted a Swedish gynecology clinic with vaginal complaints that ranged from and included abnormal discharge, irritation itching along with serious malodor. An interpretive phenomenological approach was used with an individual interview to get a more intimate understanding of the women experiencing these problems. The finding of this study shows that managing the recurrent symptoms of the infections remains to be a challenge for women as it has a clearly negative impact on the quality of their lives. Four themes developed: frustration and mood disorders, intimacy changes in the relationship, exposure, hope and relief. The women had high hopes of eliminating the symptoms within the six-month study period. The treatment program, with its well-developed guidelines and continuity of care within the context of the study greatly improved the quality of life of these women. Women had feelings of frustration and anxiety when nothing could cure their problem while they had also a great hope to get rid of the symptoms with a long striking treatment. Well-developed guidelines and continuity of care can help these women to have an improved quality of life.
Virtual reference view generation for CBIR-based visual pose estimation

Determining the pose of a mobile device based on visual information is a promising approach to solve the indoor localization problem. We present an approach that transforms localized images along a mapping trajectory into virtual viewpoints that cover a set of densely sampled camera positions and orientations in a confined environment. The viewpoints are represented by their respective bag-of-features vectors and image retrieval techniques are applied to determine the most likely pose of query images at very low computational complexity. As virtual image locations and orientations are decoupled from actual image locations, the system is able to work with sparse reference imagery and copes well with perspective distortion. Experiments confirm that pose retrieval performance is significantly improved.
Revocable and Scalable Certificateless Remote Authentication Protocol With Anonymity for Wireless Body Area Networks

To ensure the security and privacy of the patient's health status in the wireless body area networks (WBANs), it is critical to secure the extra-body communication between the smart portable device held by the WBAN client and the application providers, such as the hospital, physician or medical staff. Based on certificateless cryptography, this paper proposes a remote authentication protocol featured with nonrepudiation, client anonymity, key escrow resistance, and revocability for extra-body communication in the WBANs. First, we present a certificateless encryption scheme and a certificateless signature scheme with efficient revocation against short-term key exposure, which we believe are of independent interest. Then, a certificateless anonymous remote authentication with revocation is constructed by incorporating the proposed encryption scheme and signature scheme. Our revocation mechanism is highly scalable, which is especially suitable for the large-scale WBANs, in the sense that the key-update overhead on the side of trusted party increased logarithmically in the number of users. As far as we know, this is the first time considering the revocation functionality of anonymous remote authentication for the WBANs. Both theoretic analysis and experimental simulations show that the proposed authentication protocol is provably secure in the random oracle model and highly practical.
Climatic suitability of Portuguese grapevine varieties and climate change adaptation

Grapevine varietal suitability is strongly linked to regional environmental conditions and growers tend to select varieties that are best suited to these conditions. A high agreement between current growing regions and optimal climatic zones is thus anticipated for a given variety. A changing climate is, however, expected to impose new challenges to this long‐term varietal selection. The present research examines the spatial distribution of the main grapevine varieties in Portugal, establishing current and future optimal climatic zones for each variety. The spatial locations of 44 varieties are assessed, and their growing degree‐day (GDD) requirements are computed using a high resolution climatic dataset (<1 km). A clustering methodology is applied to the spatial patterns of the optimal GDD of each variety, leading to three varietal groupings (early, intermediate and late). Future changes (2041–2060) in those patterns are then analysed using a 17 model‐ensemble and two scenarios (RCP4.5 and 8.5). Results indicate that Portuguese varieties have high adaptability, because they are grown over a large range of thermal conditions. Although the three clusters provide a good agreement with the current growth conditions, a strong warming trend is projected in the future, resulting in projections of a northward shift and move to higher elevations for the cluster patterns. Hence, other European regions may experience improved growing conditions for the settlement of these Portuguese varieties. Nonetheless, future varietal selection will heavily depend on the interest of winemakers and global market policies for the production of specific wines. Adaptation measures may indeed be required for maintaining the current varietal distribution.
Reproductive Flexibility: Genetic Variation, Genetic Costs and Long-Term Evolution in a Collembola

In a variable yet predictable world, organisms may use environmental cues to make adaptive adjustments to their phenotype. Such phenotypic flexibility is expected commonly to evolve in life history traits, which are closely tied to Darwinian fitness. Yet adaptive life history flexibility remains poorly documented. Here we introduce the collembolan Folsomia candida, a soil-dweller, parthenogenetic (all-female) microarthropod, as a model organism to study the phenotypic expression, genetic variation, fitness consequences and long-term evolution of life history flexibility. We demonstrate that collembola have a remarkable adaptive ability for adjusting their reproductive phenotype: when transferred from harsh to good conditions (in terms of food ration and crowding), a mother can fine-tune the number and the size of her eggs from one clutch to the next. The comparative analysis of eleven clonal populations of worldwide origins reveals (i) genetic variation in mean egg size under both good and bad conditions; (ii) no genetic variation in egg size flexibility, consistent with convergent evolution to a common physiological limit; (iii) genetic variation of both mean reproductive investment and reproductive investment flexibility, associated with a reversal of the genetic correlation between egg size and clutch size between environmental conditions ; (iv) a negative genetic correlation between reproductive investment flexibility and adult lifespan. Phylogenetic reconstruction shows that two life history strategies, called HIFLEX and LOFLEX, evolved early in evolutionary history. HIFLEX includes six of our 11 clones, and is characterized by large mean egg size and reproductive investment, high reproductive investment flexibility, and low adult survival. LOFLEX (the other five clones) has small mean egg size and low reproductive investment, low reproductive investment flexibility, and high adult survival. The divergence of HIFLEX and LOFLEX could represent different adaptations to environments differing in mean quality and variability, or indicate that a genetic polymorphism of reproductive investment reaction norms has evolved under a physiological tradeoff between reproductive investment flexibility and adult lifespan.
Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson’s disease

Background: Long term effects of subthalamic nucleus (STN) stimulation on cognition, mood, and behaviour are unknown. Objective: This study evaluated the cognitive, mood, and behavioural effects of bilateral subthalamic nucleus deep brain stimulation (STN DBS) in patients with Parkinson’s disease (PD) followed up for three years. Methods: A consecutive series of 77 PD patients was assessed before, one, and three years after surgery. Mean (SD) age at surgery was 55 (8). Seven patients died or were lost for follow up. Neuropsychological assessment included a global cognitive scale, memory, and frontal tests. Depression was evaluated using the Beck depression inventory. Assessment of thought disorders and apathy was based on the unified Parkinson’s disease rating scale. Reports of the behavioural changes are mainly based on interviews done by the same neuropsychologist at each follow up. Results: Only two cognitive variables worsened (category fluency, total score of fluency). Age was a predictor of decline in executive functions. Depression improved whereas apathy and thought disorders worsened. Major behavioural changes were two transient aggressive impulsive episodes, one suicide, four suicide attempts, one permanent apathy, one transient severe depression, four psychoses (one permanent), and five hypomania (one permanent). Conclusions: Comparing baseline, one year, and three year postoperative assessments, STN stimulation did not lead to global cognitive deterioration. Apathy scores mildly increased. Depression scores mildly improved. Behavioural changes were comparatively rare and mostly transient. Single case reports show the major synergistic effects of both medication and stimulation on mood and behaviour, illustrating the importance of a correct postoperative management.
Schematic Visualization of Object Trajectories Across Multiple Cameras for Indoor Surveillances

This paper presents a video summarization method to visualize the video object trajectories across multiple cameras in a static image for monitoring the movements of suspicious people in a building. First, we have designed an object association algorithm across multiple stationary cameras, which can be used to build the object trajectories in the building with the assistants of the predefined locations of the cameras. The object associations are based on the features of human body, such as the clothing colour, stature, shoulder breadth and so on. These features are calculated from the anthropometric dimensions of the human body from calibrated monocular video sequences. Finally, the object trajectories are illustrated in a perspective picture that overviews all floors of the building, wihich is called storyboard. Some diagrammatic elements such as arrows and texts are used to annotate the object movements. Thicker arrows represent the more rapid movements and narrower arrows represent the slower movements. The visualization results can assist the monitors to real-time observe the people’s movements and easily understand the people’s activities in a building.
Differences in emotional distress among inpatients with type 1, obese type 2, and non-obese type 2 diabetes mellitus.

Objective The purpose of this study was to determine the differences in emotional distress among three groups of inpatients with type 1, obese type 2, and non-obese type 2 diabetes during hospitalization. Methods The 42 participating inpatients were divided into three groups: type 1 diabetes (n=11), obese type 2 diabetes [body mass index (BMI) ≥25 kg/m(2); n=24], and non-obese type 2 diabetes (BMI <25 kg/m(2); n=7). The Problem Areas in Diabetes (PAID) scale, which is a self-administered questionnaire to assess emotional distress in the patients with diabetes, was performed at admission and discharge. Results The total PAID score was similar and tended to improve during hospitalization in all three groups, although there were differences among the groups in the scores of particular questions. At admission, the score of the question "worrying about low blood sugar reactions? " was significantly different among the three groups and highest in the patients with type 1 diabetes. At discharge, the score of "not accepting diabetes? " was significantly different among the three groups and highest in the patients with non-obese type 2 diabetes, while that of "feeling unsatisfied with your diabetes physician? " was significantly different among the three groups and highest in the patients with obese type 2 diabetes. The score of "feelings of deprivation regarding food and meals? " significantly worsened in the patients with obese type 2 diabetes during hospitalization compared with the patients in with non-obese type 2 diabetes. Conclusion The characteristics of emotional distress during hospitalization varied among the patients with the three types of diabetes, thus emphasizing the importance of tailoring support according to the type of diabetes.
Approximate solutions for factored Dec-POMDPs with many agents

Dec-POMDPs are a powerful framework for planning in multiagent systems, but are provably intractable to solve. This paper proposes a factored forward-sweep policy computation method that tackles the stages of the problem one by one, exploiting weakly coupled structure at each of these stages. An empirical evaluation shows that the loss in solution quality due to these approximations is small and that the proposed method achieves unprecedented scalability, solving Dec-POMDPs with hundreds of agents.
Protein Kinase C Inhibitors Produce Mitochondrial Flavoprotein Oxidation in Cardiac Myocytes

Inhibition of protein kinase C (PKC) antagonizes ischemic preconditioning of myocardium. Opening of mitochondrial adenosine triphosphate (ATP)-dependent potassium (mitoKATP) channels and subsequent oxidation of mitochondria are known to contribute to ischemic preconditioning. We therefore tested the effects of PKC inhibitors on flavoprotein oxidation, measured by flavoprotein fluorescence, as an index of mitoKATP activity in ventricular myocytes from guinea pigs. The PKC inhibitors chelerythrine (1 and 5 &mgr;M) and bisindolylmaleimide (100 and 400 nM) strongly increased flavoprotein oxidation in a dose-dependent manner. Specific inhibition of PKC-&dgr; by rottlerin produced persistent flavoprotein oxidation. Inhibition of the production of inositol (1,4,5)-triphosphate by neomycin (0.5 mM) abolished chelerythrine- but not rottlerin-induced flavoprotein oxidation. Inhibition of PKC promotes flavoprotein oxidation via production of inositol (1,4,5)-triphosphate, possibly through the PKC-&dgr; isoform. We speculate that although a certain degree of mitochondrial flavoprotein oxidation causes cardioprotective effects, excessive and/or persistent oxidation abolishes any beneficial actions. Instead of a simple mediator, PKC may act as a regulator of the mitoKATP channel to prevent excessive mitochondrial oxidation.
The role of experiments in understanding fishery-induced evolution

Evidence of fishery‐induced evolution has been accumulating rapidly from various avenues of investigation. Here we review the knowledge gained from experimental approaches. The strength of experiments is in their ability to disentangle genetic from environmental differences. Common garden experiments have provided direct evidence of adaptive divergence in the wild and therefore the evolvability of various traits that influence production in numerous species. Most of these cases involve countergradient variation in physiological, life history, and behavioral traits. Selection experiments have provided examples of rapid life history evolution and, more importantly, that fishery‐induced selection pressures cause simultaneous divergence of not one but a cluster of genetically and phenotypically correlated traits that include physiology, behavior, reproduction, and other life history characters. The drawbacks of experiments are uncertainties in the scale‐up from small, simple environments to larger and more complex systems; the concern that taxons with short life cycles used for experimental research are atypical of those of harvested species; and the difficulty of adequately simulating selection due to fishing. Despite these limitations, experiments have contributed greatly to our understanding of fishery‐induced evolution on both empirical and theoretical levels. Future advances will depend on integrating knowledge from experiments with those from modeling, field studies, and molecular genetic approaches.
Lizards in the ecology of salmonellosis in Panama

Enteropathogenic bacteria was isolated from 131 of 447 (29.4%) neotropical Panamanian lizards belonging to 34 species of seven families. Overall, 147 strains of bacteria were isolated comprising 26 Salmonella and 10 Arizona serotypes. Gymnopthalmus speciosus had the highest infection rate, 12 of 13 individuals (92.3%), whereas Gonatodes fuscus exhibited the lowest, 1 of 18 (5.6%). The highest infection was detected in lizards whose behavioral patterns were secretive (42.0%) and terrestrial (42.6%), whereas the lowest infection was among the scansorial lizards (17.5%). Rates were highest during the dry season, from January through April. Many neotropical Panamanian lizards were multiply infected by Salmonella an Arizona strains representing representing a wide range of serotypes. Infected lizards were distributed in areas varying from remote rural and forested regions to urban developments, offering a potentially important reservoir of enteropathogenic bacteria known to cause infection in man and domestic animals.
Lg wave Q tomography in Central America

SUMMARY The lateral variation of Lg wave spectral attenuation in Central America was studied through tomographic inversion at various frequencies between 0.5 and 5 Hz, separately for each frequency. The input data set consisted of 558 travel paths recorded on short-period and broadband seismic stations in the region. The size and quality of the data set were sufficient to resolve significant lateral variation in the Lg wave quality factor Q Lg. The average dependence of Q Lg with frequency was found to be Q Lg( f ) = 182 f 0.84 , corresponding to high attenuation. Low Q Lg values in the Nicaraguan Depression presented the most significant variation from the average. The strong attenuation of Lg waves in the Nicaraguan depression was also observed in the visual analysis of the seismograms. This observation is possibly explained by the nearsurface low-velocity layers in the depression. Low Q Lg values were also found along the chain of volcanos due to increased scattering and partial melting beneath the volcanic belt. This study is the first attempt to determine Q Lg for Central America and to provide knowledge on attenuation of Lg waves needed for the prediction of ground motion during future earthquakes.