Miracle-dz/UniFAR-FTUs huggingface dataset:
Phacoemulsification Outcomes with Different Illumination Techniques

Purpose To compare surgeon experience and the outcomes of phacoemulsification using 2 different illumination techniques for cataract extraction. Methods A prospective interventional case series was performed on 20 consecutive patients (20 eyes) with senile cataract who underwent phacoemulsification enhanced with a 23-G endoillumination probe. The main outcome measures were the surgeon's perception of depth of field and quality of visibility of intraocular structures, ease of performance of the surgical procedure, effectiveness, and complications related to the procedure. A surgeon-specific questionnaire was administered at the end of the procedure. Results Surgery was successfully performed in all patients without any complications. The surgeon indicated that lateral endoillumination markedly enhanced the details of the lens structures, mainly the posterior capsule visualization, better than the coaxial lighting with the surgical microscope. Lateral endoillumination created an enhanced 3D effect and improved the depth perception of lens intraoperatively. Conclusions The lateral illumination technique with a 23-G endoilluminator probe placed in the anterior chamber through a paracentesis creates an enhanced 3D effect and improves depth perception of lens during phacoemulsification. These benefits increase the safety of the procedure.
Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat pancreatic α-cells.

AIM To investigate the mechanism behind β-cell regeneration in neonatal rat pancreas treated with streptozotocin (STZ). METHODS Neonatal Sprague Dawley rats were intraperitoneally injected with 70 mg/kg STZ. Body weight, pancreas weight and blood glucose were recorded every two days after the treatment. To identify the expression and location of transcription factors in the rat pancreas, double immunofluorescent staining was performed using antibodies to specific cell markers and transcription factors. RESULTS Expression of Neurogenin 3 (Ngn3), a marker for endocrine precursor cells, was observed by immunofluorescence in a few β-cells and many α-cells. The expression reached a peak 12 d after treatment. Pax4, a transcription factor that lies downstream of Ngn3 and plays an important role in β-cell differentiation, was also expressed in the α-cells of STZ-treated rats. We did not observe significant changes in Nkx6.1, which is essential for β-cell maturation in the treated rats. CONCLUSION α-cells dedifferentiated into endocrine precursor cells and acquired the ability to dedifferentiate in the neonatal rat pancreas after STZ treatment.
War and Well-Being in Transition: Russo-Georgian Conflict as a Natural Experiment

This paper assesses the effect of the Russo-Georgian conflict of 2008 on the well-being of minorities in Russia. Using the Russian Longitudinal Monitoring Survey (RLMS), we first provide evidence that, on impact, the well-being of Georgian nationals suffered negatively from the conflict of 2008, both in comparison to their own well-being across time and to the well-being of the Russian majority. We also show that this negative effect of conflict does not have a long-term legacy that goes beyond 2008. Additionally, we demonstrate that the conflict has no direct effect on the livelihoods or the labor market outcomes of Georgian nationals. Therefore, we attribute the negative effect of conflict on well-being to more indirect channels such as fear, altruism, or sympathy. We also analyze the spillover effects of the Russo-Georgian conflict on other minorities that live in Russia. We find that while the well-being of migrant minorities who have recently moved to Russia is negatively affected, there is no effect on local minorities who have been living in Russia for at least ten years.
Oxidative stress, photodamage and the role of screening pigments in insect eyes

SUMMARY Using red-eyed mutant triatomine bugs (Hemiptera: Reduvidae), we tested the hypothesis of an alternative function of insect screening pigments against oxidative stress. To test our hypothesis, we studied the morphological and physiological changes associated with the mutation. We found that wild-type eyes possess a great amount of brown and red screening pigment inside the primary and secondary pigment cells as well as in the retinular cells. Red-eyed mutants, however, have only scarce red granules inside the pigmentary cells. We then compared the visual sensitivity of red-eyed mutants and wild types by measuring the photonegative responses of insects reared in light:dark cycles [12 h:12 h light:dark (LD)] or constant darkness (DD). Finally, we analyzed both the impact of oxidative stress associated with blood ingestion and photodamage of UV light on the eye retina. We found that red-eyed mutants reared in DD conditions were the most sensitive to the light intensities tested. Retinae of LD-reared mutants were gradually damaged over the life cycle, while for DD-reared insects retinae were conserved intact. No retinal damage was observed in non-fed mutants exposed to UV light for 2 weeks, whereas insects fed on blood prior to UV exposure showed clear signs of retinal damage. Wild-type insects exposed to UV light showed a marked increase in the amount and density of screening pigments.
The Effects of a 7-Week Heavy Elastic Band and Weight Chain Program on Upper-Body Strength and Upper-Body Power in a Sample of Division 1-AA Football Players

Ghigiarelli, JJ, Nagle, EF, Gross, FL, Robertson, RJ, Irrgang, JJ, and Myslinski, T. The effects of a 7-wk heavy elastic band and weight chain program on upper body strength and upper body power in a sample of Division 1-AA football players. J Strength Cond Res 23(3): 756-764, 2009-The purpose of this study was to explore the effects of a 7-week heavy elastic band and weighted-chain program on maximum muscular strength and maximum power in the bench press exercise. Thirty-six (n = 36) healthy men aged 18-30 years old, from the Robert Morris University football team, volunteered to participate in this study. During the first week, predicted 1 repetition maximum (1RM) bench press and a 5RM speed bench press tests were conducted. Subjects were randomly divided into 3 groups (n = 12): elastic band (EB), weighted chain (WC), and traditional bench (C). During weeks 2-8 of the study, subjects were required to follow the prescribed resistance training program. Mean and SD of the predicted 1RM bench press and 5RM speed bench press were computed. A two-factor (method X time) analysis was applied to identify significant differences between the training groups. Significance was set at α = 0.05. Results indicated a significant time (p < 0.05) but no group effect for both predicted 1RM (kg) and 5RM peak power tests (watts). Although not significant, results did show greater nonsignificant improvements in the EB (848-883 W) and WC groups (856-878 W) vs. control (918-928 W) when the 2 highest and greatest values were selected regarding peak power. The use of EB and WC in conjunction with a general offseason strength and conditioning program can increase overall maximum upper-body strength in a sample of Division 1-AA football players. These types of training modalities add a unique training style and more flexibility with respect to exercise prescription for athletes and strength practitioners.
Frequency of Common CYP2C9 Polymorphisms and Their Impact on Warfarin Dose Requirement in Pakistani Population

Polymorphisms in cytochrome P450 (CYP) 2C9 (CYP2C9) gene result in interindividual variability in warfarin dose requirement. There is a need for characterization of genotype frequency distribution in different populations for construction of customized dosing algorithms to enhance the efficacy and reduce the toxicity of warfarin therapy. This study was carried out in Pakistani population to evaluate the contribution of common CYP2C9 polymorphisms to warfarin therapy. A total of 550 stable patients taking warfarin were enrolled after medical history, physical examination, and laboratory investigations. Single blood sample was collected after informed consent. Genomic DNA was extracted, and genotype analysis for CYP2C9*2 and CYP2C9*3 polymorphisms was done by polymerase chain reaction-restriction fragment length polymorphism assay. A number of samples were also analyzed by direct DNA sequencing for validation of the results. Data were analyzed using SPSS version 20. Genotype frequency distribution of CYP2C9*2 and CYP2C9*3 was found to be different from other populations. Of these 2 polymorphisms, CYP2C9*2 did not demonstrate significant effect on warfarin dose requirement, whereas CYP2C9*3 did show significant effect (P value = .012). It is concluded that there is a need to study genotype frequency distribution and their effect on warfarin dose variability among different populations due to diversity in outcome.
Network Therapy for Addiction: Bringing Family and Peer Support into Office Practice

Abstract Network therapy was developed as a specialized type of combined individual and group therapy to ensure greater success in the office-based treatment of addicted patients by using both psychodynamic and cognitive-behavioral approaches to individual therapy while engaging the patient in a group support network composed of family members and peers. This article outlines the role of group cohesiveness as a vehicle for engaging patients in this treatment; the patient’s family and peers are used as a therapeutic network, joining the patient and therapist at intervals in therapy sessions. This network is managed by the therapist to provide cohesiveness and support, to undermine denial, and to promote compliance with treatment. The author presents applications of the network technique designed to sustain abstinence and describes means of stabilizing the patient’s involvement. Some specific techniques discussed include ambulatory detoxification, disulfiram and naltrexone administration, relapse prevention, and contingency contracting. Also discussed are recent research on the use of psychiatric residents and counselors for treatment, and use of the Internet in dissemination.
Mitigating link insecurities in smart grids via QoS multi-constraint routing

We consider the problem of enhancing communication security while maintaining quality of service (QoS) through the communication networks of smart grid systems. Specifically, this work employs software defined networks (SDN) framework to mitigate insecure communication links while maintaining satisfactory QoS essential to control functionality of the smart grid. An SDN is able to maintain an overall network awareness, through which a controller is capable of optimizing routing based on metrics of interest. The routing problem is formulated as a double constraint shortest path problem where dynamic delay is the QoS metric with an additional constraint of link vulnerability. The proposed framework is shown, in different test cases, to be able to maintain QoS while mitigating link insecurities.
Inequality and Poverty Across Generations in the European Union

This SDN studies the evolution of inequality across age groups leading up to and since the global financial crisis, as well as implications for fiscal and labor policies. Europe’s population is aging, child and youth poverty are rising, and income support systems are often better equipped to address old-age poverty than the challenges faced by poor children and/or unemployed youth today.
Anatomicohistological Characteristics of the Genital Tubular Organs of the Female Brush‐tailed Porcupine (Atherurus africanus, Gray 1842) from Gabon

The present study examines the anatomic and histological characteristics of the female genital tract of the wild brush‐tailed porcupine (Atherurus africanus). A description of the macroscopic and microscopic features of the tubular genital organs based on observations made in 18 wild adult females is presented. The histological stains used were haematoxylin and eosin, 1% toluidine blue, PAS–haematoxylin and Masson's trichrome. Observations indicate that the fimbriated infundibulum of the oviduct completely surrounds and is attached to the entire ovarian surface. The uterus is bicornuate, being composed of two uterine horns separated by a velum uteri, a small uterine body and a cervix. In both pregnant and non‐pregnant females, the uterine horns and body of the uterus present a pseudostratified, columnar ciliated epithelium containing sparse simple tubular glands. In pregnant females, the endocervical canal is filled by a viscous cervical secretion. The different patterns observed in the endometrium and myometrium of the uterine horns and in the vaginal epithelium suggest a relationship with the reproductive state of the brush‐tailed porcupine female.
Potential interaction between zinc ions and a cyclodextrin-based diclofenac formulation

Abstract Complexes of diclofenac sodium (DF-Na) with hydroxypropyl betacyclodextrin (HPβCD) were prepared by co-evaporation in a 1:1 ratio and characterized in light of previously reported data. Phase solubility diagrams were obtained for DF-Na with HPβCD in the presence and absence of zinc ions. Dissolution profiles were obtained for DF-Na and its HPβCD complex at acidic (pH 1.2) as well as in phosphate buffer (pH 6.8), in the presence and absence of zinc. HPβCD, as expected, was shown to improve the dissolution of DF-Na in acidic medium but not in phosphate buffer (pH 6.8). The presence of zinc ions decreased the in vitro dissolution of DF-HPβCD complex in acidic medium (pH 1.2) but not in phosphate buffer (pH 6.8). It was confirmed that the precipitate that was formed by zinc ions in the presence of HPβCD and DF-Na contained no cyclodextrin and most likely it was a mixture of the complexes: DF2-Zn and DF-Zn with some molecules of water. In vivo experiments on rats have shown that HPβCD has no statistically significant effect on absorption or bioavailability of DF-Na in spite of the observed improvement of its in vitro dissolution by HPβCD. Moreover, zinc ions were shown to decrease the absorption rate of DF-Na in rats model but did neither significantly alter the absorption nor bioavailability of DF-HPβCD complex. The zinc induced precipitates of DF were shown to have significantly different crystalline properties when HPβCD was present. Therefore, the pharmaceutical details of a DF-Na preparation should be considered when designing the formulation and predicting possible interaction between DF-Na (or other potential NSAIDs) and zinc metal.
Smoking and smoking cessation in relation to the development of co‐existing non‐small cell lung cancer with chronic obstructive pulmonary disease

Previous studies have identified a mixed‐phenotype of non‐small cell lung cancer (NSCLC) with co‐existing chronic obstructive pulmonary disease (COPD). Although NSCLC and COPD share a common risk factor in smoking, whether and how smoking may contribute to the coexistence of NSCLC with COPD (NSCLC‐COPD) is unclear. Our study suggests that cigarette smoking is the major risk factor for the development of NSCLC‐COPD, especially in females and among patients with squamous cell carcinoma subtype.
Effects of Basal Insulin Supplementation on Disposition of Mixed Meal in Obese Patients With NIDDM

Basal insulin supplementation has been used as a therapy for patients with non-insulin-dependent diabetes mellitus (NIDDM) who require insulin. To determine whether basal insulin supplementation in addition to lowering postabsorptive plasma glucose concentration also improves the postprandial pattern of glucose disposition, glucose metabolism after ingestion of a solid mixed meal was assessed in obese patients with NIDDM before and after treatment with ultralente and compared with glucose metabolism observed in nondiabetic subjects. Splanchnic uptake of ingested glucose clearance was assessed by including [2-3H]glucose (a tracer that only minimally cycles through glycogen) in a solid mixed meal. Postprandial gluconeogenesis was estimated by measuring the rate of incorporation of carbon dioxide into glucose. Net glucose and lipid oxidation were measured by indirect calorimetry. Both splanchnic uptake of ingested glucose (27 ± 1 vs. 14 ± 2 g) and postprandial hepatic glucose release (51 ± 5 vs. 24 ± 3 g) were greater (P < .001) in diabetic than in nondiabetic subjects. Although the percentage of postprandial hepatic glucose release accounted for by glucose synthesis from bicarbonate was similar in the two groups (25 ± 2 vs. 35 ± 5%), the absolute rate was greater in the diabetic patients (13 ± 1 vs. 8 ± 1 g; P < .05). Postprandial glucose oxidation and glucose disposal (measured either isotopically or by the forearm-catheterization technique) were similar in both groups. However, total lipid oxidation was increased in the diabetic patients. (P < .05). Two weeks of basal insulin supplementation lowered fasting glucose concentrations (from 219 ± 22 to 144 ± 21 mg/dl; P < .01) and integrated postprandial glycemic response (from 814 ± 68 to 621 ± 72 min · mg· ml−1) but not to normal. Although circulating insulin concentrations were two- to threefold greater (P < .02) after 3 mo of basal insulin supplementation, the postprandial pattern of glucose metabolism remained essentially the same. Basal insulin supplementation decreased (P < .05) both splanchnic uptake of ingested glucose and hepatic glucose release. The addition of a preprandial injection of soluble insulin to basal insulin supplementation further suppressed (P < .05) postprandial hepatic glucose release, thereby further improving postprandial glucose tolerance. These studies indicate that initial splanchnic glucose clearance, hepatic glucose release, and new glucose synthesis, as well as extrahepatic substrate metabolism, are altered in NIDDM after ingestion of a mixed meal. Basal insulin supplementation improves but does not normalize postprandial glucose metabolism.
Outcomes in pediatric neurology: a review of conceptual issues and recommendationsThe 2010 Ronnie Mac Keith Lecture

This paper discusses how to evaluate whether, and in what ways, treatments affect the lives of children with neurological conditions and their families. We argue that professionals should incorporate perspectives from patients and families to help them make decisions about what ‘outcomes’ are important, and we discuss how those outcomes might be assessed. A case vignette illustrates the differences and complementarity between the perspectives of clinicians and those of children and their parents. We recommend methods for expanding the range of relevant health outcomes in child neurology to include those that reflect the ways patients and families view their conditions and our interventions. We explore the added value of a ‘non‐categorical’ approach to the choice of outcomes. The International Classification of Functioning, Disability and Health is a useful biopsychosocial framework to ‘rule in’ relevant aspects of child and family issues to create a dynamic system of possible influences on outcomes. We examine the meaning of ‘health’, ‘health‐related quality of life’, and ‘quality of life’ as related but conceptually distinct outcomes. Specific issues are discussed about the construction, validation, and appraisal of outcome measures, as well as practical recommendations on how to select outcome measures in the clinical setting and research.
Investigating the Effect of Investors' Behavior and Management on the Stock Returns: Evidence from Iran

The purpose of the present study is to investigate the effect of behavioral variables on overconfidence in management, herding behavior and investors' emotional tendency on stock return. To this end, by using the data of firms listed in the Iran's Stock Exchange during the seven-year period of 2010-2016, overconfidence index in management, the herding behavior of the investors and the emotional tendency of the investors were calculated and their impact on stock return was examined. The data of the research are of a panel type and for analyzing the data and testing the hypotheses; a multiple linear regression model has been used. Evidence from the experimental results of the research showed that the behavioral variables studied in the research has a significant and inverse effect on the stock return of the companies.
Work status and chronic low back pain: exploring the international classification of functioning, disability and health

Purpose. Exploring which variables are related to work status in patients with chronic low back pain (CLBP), classified according to the International Classification of Functioning, Disability and Health (ICF). Method. Ninety-two patients with CLBP filled out questionnaires inquiring after health status, impairments in body functions/structures, limitations in activities of daily living (ADL), participation in work, environmental and personal factors. Additionally, patients performed tests to measure physical fitness and performance of work-related activities. Univariate analyses were performed to investigate whether differences exist between working and non-working patients. Logistic linear regression analysis was performed to explain work status from the variables of functioning. Results. Non-working patients had a lower self-reported physical and mental health, lower physical fitness, more self-reported limitations in ADL, lower education, more depressive symptoms and higher psycho neuroticism than working patients. Self-reported physical and mental health and educational level correctly classified 84.5% of the patients as working or non-working. Performance of work-related activities was not significantly related with work-status. Conclusions. The relation between work status and CLBP is multidimensional, as was illustrated by using the bio-psychosocial model of the ICF. Patients with a low educational level, a low self-reported physical or mental health were more likely to be non-working. Self-reported limitations and physical and mental health are more important in explaining work status than objective measurements of performance.
Service Characteristics and Geographical Variation in Compulsory Hospitalisation: An Exploratory Random Effects Within–Between Analysis of Norwegian Municipalities, 2015–2018

Background: Compulsory hospitalisation in mental healthcare is contested. For ethical and legal reasons, it should only be used as a last resort. Geographical variation could indicate that some areas employ compulsory hospitalisation more frequently than is strictly necessary. Explaining variation in compulsory hospitalisation might contribute to reducing overuse, but research on associations with service characteristics remains patchy. Objectives: We aimed to investigate the associations between the levels of compulsory hospitalisation and the characteristics of primary mental health services in Norway between 2015 and 2018 and the amount of variance explained by groups of explanatory variables. Methods: We applied random-effects within–between Poisson regression of 461 municipalities/city districts, nested within 72 community mental health centre catchment areas (N = 1,828 municipality-years). Results: More general practitioners, mental health nurses, and the total labour-years in municipal mental health and addiction services per population are associated with lower levels of compulsory hospitalisations within the same areas, as measured by both persons (inpatients) and events (hospitalisations). Areas that, on average, have more general practitioners and public housing per population have lower levels of compulsory hospitalisation, while higher levels of compulsory hospitalisation are seen in areas with a longer history of supported employment and the systematic gathering of service users' experiences. In combination, all the variables, including the control variables, could account for 39–40% of the variation, with 5–6% related to municipal health services. Conclusion: Strengthening primary mental healthcare by increasing the number of general practitioners and mental health workers can reduce the use of compulsory hospitalisation and improve the quality of health services.