Miracle-dz/UniFAR-FTUs huggingface dataset:
Performances of high numerical aperture water and oil immersion objective in deep‐tissue, multi‐photon microscopic imaging of excised human skin

Multi‐photon fluorescence microscopy (MPFM) is a powerful technique for imaging scattering, biological specimens in depth. In addition to the sectioning effect generated by the point‐like excitation volume, the near‐infrared wavelengths used for multi‐photon excitation allow deeper penetration into optically turbid specimens. In physiological specimens, the optical properties such as the scattering coefficients and refractive indices are often heterogeneous. In these specimens, it is not clear which type of immersion objective can provide optimized images in‐depth. In particular, in‐depth dermatological imaging applications using MPFM requires such optimization to obtain qualitative and quantitative information from the skin specimens. In this work, we address this issue by comparing the performances of two common types of high numerical aperture (NA) objectives: water‐immersion and oil‐immersion. A high‐quality water‐immersion objective (Zeiss, 40× C‐Apochromat, NA 1.2) and a comparable oil‐immersion objective (Zeiss, 40× Fluar, NA 1.25) were used for in‐depth imaging of autofuorescent excised human skin and sulforhodamine B treated human skin specimens. Our results show that in the epidermal layers, the two types of immersion objectives perform comparably. However, in the dermis, multi‐photon imaging using the oil immersion objective results in stronger fluorescence detection. These observations are most likely due to the degraded point‐spread‐function (PSF) caused by refractive index mismatch between the epidermis and the dermis. Microsc. Res. Tech. 63:81–86, 2004. © 2003 Wiley‐Liss, Inc.
The heart sound de-noising method based on the wavelet packet and local noise estimation

Heart sound is a kind of typical non-stationary weak signal. Heart sounds from clinical settings are unavoidably contaminated by some noise. The noise in heart sounds includes colored noise and white noise. A de-noising method is presented in this paper, which is based on a harmonic wavelet packet and adopts the methods of finding an optimal decomposing under the minimum entropy principle, selecting reasonable decomposing depths and estimating the local noise as de-noising thresholds. The experiment results show that the method is effective.
Automatic Detection of Refactorings for Libraries and Frameworks

Current work on automatic detection of refactorings typically assumes a closed-world, i.e., codebases used only in-house. Changes in closed-world happen abruptly, and refactorings are easier to spot. Libraries and frameworks are developed to be reused outside the organization and therefore the changes do not happen overnight but follow a long deprecate-replace-remove cycle. Obsolete entities will coexist with their newer counterparts until they are no longer supported. This lifecycle introduces enough noise that current tools cannot accurately detect the refactorings. We propose a methodology and a tool that fits with an open-world paradigm. We use a Shingles algorithm to detect clones of the same entity and then refine the results with semantic analysis. Preliminary evaluation shows that our method scales for real-life libraries and can accurately detect when entities are renamed or moved.
The use of matrix perturbation theory for addressing sensitivity and uncertainty issues in LCA

LCA, even when modeled in the traditional way with linear equations, may show strong non-linear sensitivities. Well-developed tools from matrix perturbation theory may be employed to investigate LCA systems for the presence and location of such extreme sensitivities. This knowledge is useful for stability analysis, error analysis and for detecting and resolving round-off problems in the computations. INTRODUCTION It is well known that models that comprise highly non-linear functions may exhibit a large sensitivity with respect to the dependency of output on input. For instance, when a modeled relationship is based on the tangent of a certain input coefficient, say x y tan changing the input from x = 1.5 to x = 1.55 will result in a change of output from y = 14 into y = 48. Since the advent of chaos theory in the eighties, a similar phenomenon has been observed for models with weak non-linearities. One famous example is the system of three differential equations bz xy z y z r x y x y s x
Understanding dynamic change in perceptions of person-environment fit: An exploration of competing theoretical perspectives

The longstanding assumption in person–environment (PE) fit research is that perceived fit embodies the subjectively experienced match between personal and environmental attributes and hence triggers affect and behavior (i.e., normal causation perspective). This argument is however increasingly debated, with some scholars suggesting that the causal flow may also run from affect and behavior to perceived fit (i.e., reverse causation perspective), and others even arguing that perceptions of PE fit are not substantially different from how people feel and think about their environment (i.e., synchronous relationship perspective). In this research, we propose that these three competing perspectives correspond with different assumptions on how PE fit perceptions dynamically change over time (i.e., by means of comparative reasoning, logical deduction, or heuristic thinking). We empirically validate these three competing perspectives by teasing out the causal ordering of the within-person relationships between perceptions of fit and workplace affect and performance. In two separate diary studies, one with weekly (N = 153) and one with daily (N = 77) repeated measures, support was found for the synchronous relationship perspective with heuristic thinking as the plausible underlying process. This research contributes to the PE fit literature by providing new insight into the dynamic nature of perceived fit.
A Pitch Estimation Filter robust to high levels of noise (PEFAC)

We present PEFAC, a fundamental frequency estimation algorithm that is able to identify the pitch of voiced frames reliably even at negative signal to noise ratios. The algorithm combines non-linear amplitude compression, to attenuate narrow-band noise components, with a comb-filter applied in the log-frequency power spectral domain, whose impulse response is chosen to attenuate smoothly varying noise components. We compare the performance of our algorithm with that of other widely used algorithms on a subset of the TIMIT database and demonstrate that it performs exceptionally well in both high and low levels of additive noise.
How managers experience situations involving employee mental ill-health

Purpose Mental health conditions such as depression are prevalent in working adults, costly to employers, and have implications for legal liability and corporate social responsibility. Managers play an important role in determining how employees’ and organizations’ interests are reconciled in situations involving employee mental ill-health issues. The purpose of this paper is to explore these situations from the perspective of managers in order to develop theory and inform practice in workplace mental health promotion. Design/methodology/approach Semi-structured interviews were conducted with 24 Australian managers who had supervised an employee with a mental health issue. Interview transcripts were content analyzed to explore themes in managers’ experiences. Findings Managing an employee with a mental health issue involves becoming aware of the issue, taking action to understand the situation and develop an action response, implementing the response and managing the ongoing situation. Each of these tasks had a range of positive and negative aspects to them, e.g., managing the situation can be experienced as both a source of stress for the manager but also as an opportunity to develop greater management skills. Practical implications Understanding line managers’ experiences is critical to successful implementation of HR policies regarding employee health and well-being. HR strategies for dealing with employee mental health issues need to consider implementation support for managers, including promotion of guiding policies, training, emotional support and creating a psychosocial safety climate in their work units or teams. Originality/value The insights gained from this study contribute to the body of knowledge regarding psychosocial safety climate, an emergent theoretical framework concerned with values, attitudes and philosophy regarding worker psychological health. The findings also have important implications for strategic human resource management approaches to managing mental health in the workplace.
Strategies for texturing Building Models with low Resolution infrared Image Sequences

Focus of this paper is a strategies for texturing building models with partial images extracted from infrared image sequences. A given 3d building model is used for the projection of the images into the 3d object space. Caused by an insufficient camera position from the GPS the outer orientation of the virtual camera has to be corrected. Two different concepts are used depending on the geometric condition of the recorded scene and model. For scenes with many geometrical details visible in the corresponding 3d model view, the first concept is used. The polygons of the faces of the 3d model are projected into the IR image and matched to the edges for assigning the correct parts of the image to the corresponding faces of the model. These image parts are then projected onto the faces and stored as surface textures. For scenes with only few visible geometry in the projected 3d model, the second concept assumes a homography to detect surface planes of facades in two subsequent images and generates a camera path relative to those planes. Then, theses planes are matched to the 3d model to generate the final camera path. Generally, a single image does not show a complete building facade. The extracted textures of the images are combined to create complete textures for the model surfaces. For analyzing buildings these textures can be used for extraction of features or recognition of objects in a corrected image space.
Evolution of the Luminosity Density in the Universe: Implications for the Nonzero Cosmological Constant

We show that evolution of the luminosity density of galaxies in the universe provides a powerful test for the geometry of the universe. Using reasonable galaxy evolution models of population synthesis that reproduce the colors of local galaxies of various morphological types, we have calculated the luminosity density of galaxies as a function of redshift z. Comparison of the result with recent measurements by the Canada-France Redshift Survey in three wave bands of 2800 Å, 4400 Å, and 1 μm at z < 1 indicates that the Λ-dominated flat universe with λ0 ~ 0.8 is favored, and the lower limit on λ0 yields 0.37 (99% C.L.) or 0.53 (95% C.L.) if Ω0 + λ0 = 1. The Einstein-de Sitter universe with (Ω0, λ0) = (1, 0) and the low-density open universe with (0.2, 0) are, however, ruled out with 99.86% C.L. and 98.6% C.L. , respectively. The confidence levels quoted apply unless the standard assumptions on galaxy evolution are drastically violated. We have also calculated a global star formation rate in the universe to be compared with the observed rate beyond z ~ 2. We find from this comparison that spiral galaxies are formed from material accreted over an extended period of a few Gyr, while elliptical galaxies are formed from an initial starburst at z ≳ 5 that supplies enough metals and ionizing photons in the intergalactic medium.
The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions

STAT5 interacts with other factors to control transcription, and the mechanism of regulation is of interest as constitutive active STAT5 has been reported in malignancies. Here, LSD1 and HDAC3 were identified as novel STAT5a interacting partners in pro-B cells. Characterization of STAT5a, LSD1 and HDAC3 target genes by ChIP-seq and RNA-seq revealed gene subsets regulated by independent or combined action of the factors and LSD1/HDAC3 to play dual role in their activation or repression. Genes bound by STAT5a alone or in combination with weakly associated LSD1 or HDAC3 were enriched for the canonical STAT5a GAS motif, and such binding induced activation or repression. Strong STAT5 binding was seen more frequently in intergenic regions, which might function as distal enhancer elements. Groups of genes bound weaker by STAT5a and stronger by LSD1/HDAC3 showed an absence of the GAS motif, and were differentially regulated based on their genomic binding localization and binding affinities. These genes exhibited increased binding frequency in promoters, and in conjunction with the absence of GAS sites, the data indicate a requirement for stabilization by additional factors, which might recruit LSD1/HDAC3. Our study describes an interaction network of STAT5a/LSD1/HDAC3 and a dual function of LSD1/HDAC3 on STAT5-dependent transcription, defined by protein–protein interactions, genomic binding localization/affinity and motifs.
Visualizing the embedding of objects in Euclidean space

Michael Littman, Deborah F. Swayne, Nathaniel Dean, and Andreas Buja Bellcore Morristown, NJ 07962-1910 ABSTRACT Matrices representing dissimilarities within a set of objects are familiar in mathematics, statistics and psychology. In this paper we describe XGvis, a software system which accepts diverse input data, such as graphs and multivariate data, develops a dissimilarity matrix from the data, and then iteratively and interactively embeds objects in a Euclidean space of arbitrary dimension. Using a technique called multidimensional scaling, objects are positioned so that their pairwise distances match the target dissimilarities as well as possible. Users can interact with XGobi, a software system for visualizing highdimensional data, to browse the resulting embeddings. Mathematicians and statisticians have found XGvis to be useful for discovering and exploring structure. XGvis runs under the X Window SystemTM.
Extended state observer based mismatched turbulence disturbance rejection for air-breathing hypersonic vehicle

In this paper, a novel generalized extended state observer based control (GESOBC) method is proposed for air-breathing hypersonic vehicle (AHSV) with turbulence disturbances. The dynamic mathematical model with the unmatched turbulence disturbances is established and linearized at operation points. Then a novel generalized extended state observer (GESO) is proposed, which reconstructs the turbulence disturbances. Furthermore, the controller is designed based on the estimated information, which guarantees that all the signals in the closed loop system is bounded and the output signals (the velocity and the flight path angle of AHSV) go to zero asymptotically, i.e., the turbulence disturbances are removed from the output channels in steady state. Finally, the simulation example based on a AHSV is used to illustrate the efficiency of the proposed approaches.
Efficient MUS extraction with resolution

We report advances in state-of-the-art algorithms for the problem of Minimal Unsatisfiable Subformula (MUS) extraction. First, we demonstrate how to apply techniques used in the past to speed up resolution-based Group MUS extraction to plain MUS extraction. Second, we show that model rotation, presented in the context of assumption-based MUS extraction, can also be used with resolution-based MUS extraction. Third, we introduce an improvement to rotation, called eager rotation. Finally, we propose a new technique for speeding-up resolution-based MUS extraction, called path strengthening. We integrated the above techniques into the publicly available resolution-based MUS extractor HaifaMUC, which, as a result, now outperforms leading MUS extractors.
Failed Adoptive Immunotherapy with Tumor-Specific T Cells

Adoptive immunotherapy with tumor-specific T cells has emerged as a valid approach for prevention or treatment of diseases, such as melanoma and EBV-associated lymphoma. As interleukin (IL) 15 promotes survival of CD8+ memory CTLs, we hypothesized that it could be used to enhance antitumor immunity in vivo through the maintenance of adoptively transferred memory CTL. To test this, we treated mice bearing P1A+ tumors with adoptively transferred T cells possessing a transgenic Vα8+ T-cell receptor specific for the P1A tumor antigen (called P1CTL). Mice were then randomized to receive daily low-dose IL-15 (0.5 μg/day) or PBS. Mice receiving the transgenic P1CTL and IL-15 experienced a significantly delayed tumor relapse or complete tumor regression (P < 0.002 compared with PBS), with a striking persistence of the CD8+ Vα8+ P1CTL compared with mice receiving the CD8+ Vα8+ P1CTL and PBS vehicle (26.3 versus 5.1% P < 10−5). Animals exhibiting complete tumor regression had a significant population of CD8+ Vα8+ P1CTL (46%) that persisted with IL-15 treatment until 140 days after adoptive transfer and successfully defended them against tumor rechallenge without IL-15. Low-dose IL-2 afforded no protection over vehicle and resulted in lower percentages of T cells with an activated memory phenotype, lower Bcl-2 expression, and lower ex vivo antitumor cytotoxicity compared with mice treated with IL-15. Collectively, the data support the notion that exogenous low-dose IL-15 therapy can enhance and even reverse the limited efficacy of adoptively transferred tumor-specific T-cell therapy and may do so in a fashion that is superior and distinct from exogenous IL-2 therapy.
Calibration in Older and Middle-aged Drivers: Relationship between Subjective and Objective Glance Performance at Complex Intersections

Older drivers are an at-risk population for automobile crashes, especially at intersections. Intersection maneuvers demand a series of motor and visual responses executed at specific proximities and timings during a turn. Previous research indicates that older drivers are more likely than middle-aged drivers to neglect anticipatory glances to areas where latent hazards could materialize at intersections. Calibration, which reflects the degree of agreement (or discordance) between a driver’s self-perception of their driving ability and their actual ability, might be a factor that drives the age-related differences in visual scanning at intersections. This study examined relationships between eye movement patterns while driving through intersection scenarios in a medium-fidelity simulator and their subjective performance scores for middle-aged and older drivers. The data indicated no difference in calibration scores between older and middle-aged drivers. However, data showed that older drivers with higher subjective performance executed fewer secondary glances: this pattern was not present for middle aged drivers. Further research is necessary to identify psychological mechanisms involving driver calibration that control the age-related declines in anticipatory glance behavior at intersections.
Quantum random walk search on satisfiability problems

Using numerical simulation, we measured the performance of several potential quantum algorithms, based on quantum random walks, to solve Boolean satisfiability (SAT) problems. We develop the fundamentals of quantum computing and the theory of classical algorithms to indicate how these algorithms could be implemented. We also discuss the development of quantum random walks and the principles that go into creating them, presenting existing work on search algorithms using coined discrete-time quantum random walks. Although our quantum algorithms do not solve SAT problems faster than may be done classically, as a step toward that objective, we present the first example of a quantum walk on a directed graph that has a significant increase in speed over the analogous classical walk.
Temporal and spatial variations of post-seismic deformation following the 1999 Chi-Chi, Taiwan earthquake

SUMMARY We use GPS displacements collected in the 15 months after the 1999 Chi-Chi, Taiwan earthquake (M w 7.6) to evaluate whether post-seismic deformation is better explained by afterslip or viscoelastic relaxation of the lower crust and upper mantle. We find that all viscoelastic models tested fail to fit the general features in the post-seismic GPS displacements, in contrast to the satisfactory fit obtained with afterslip models. We conclude that afterslip is the dominant mechanism in the 15-month period, and invert for the space‐time distribution of afterslip, using the Extended Network Inversion Filter. Our results show high slip rates surrounding the region of greatest coseismic slip. The slip-rate distribution remains roughly stationary over the 15-month period. In contrast to the limited coseismic slip on the �
Vibration control of a marine centrifugal pump using floating raft isolation system

In order to study the influence of floating raft isolation system (FRIS) on the vibration characteristics of marine pump, a marine centrifugal pump with/without FRIS under the same operation condition, which specific speed is 66.7, was experimentally measured. The maximum efficiency of the pump is 75.8%, which is under 1.2Qd. Results show that the characteristic frequencies in the vibration spectrums of the pump with/without FRIS are APF (axial passing frequency), the BPF (blade passing frequency) and its high-order harmonic frequency. After installing FRIS, under 0.8Qd, 1.0Qd and 1.2Qd, the vibration intensity of the pump at inlet flange is slighter than that at pump base and larger than that at pump bracket. The vibration intensity at outlet flange is slighter than that at the pump bracket and larger than that at pump body, and the vibration intensity at connecting plate is the lowest. The vibration velocity level of pump base decreases with the increase of flow rate, the maximum vibration intensity at M1–M4 is reduced by 88% than that without FRIS, and the maximum vibration velocity of the APF at M1–M4 is reduced by 83.3% than that without FRIS.
Do you know more when it matters less?

According to intellectualism, what a person knows is solely a function of the evidential features of the person's situation. Anti-intellectualism is the view that what a person knows is more than simply a function of the evidential features of the person's situation. Jason Stanley (2005) argues that, in addition to “traditional factors,” our ordinary practice of knowledge ascription is sensitive to the practical facts of a subject's situation. In this paper, we investigate this question empirically. Our results indicate that Stanley's assumptions about knowledge ascriptions do not reflect our ordinary practices in some paradigmatic cases. If our data generalize, then arguments for anti-intellectualism that rely on ordinary knowledge ascriptions fail: the case for anti-intellectualism cannot depend on our ordinary practices of knowledge ascription.