Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells

Immunotoxins as antiviral therapeutics are largely unexplored but have promising prospective due to their high selectivity potential and their unparalleled efficiency. One recent example targeted the virus-encoded G protein-coupled receptor US28 as a strategy for specific and efficient treatment of human cytomegalovirus (HCMV) infections. US28 is expressed on virus-infected cells and scavenge chemokines by rapid internalization. The chemokine-based fusion-toxin protein (FTP) consisted of a variant (F49A) of CX3CL1 specifically targeting US28 linked to the catalytic domain of Pseudomonas exotoxin A (PE). Here, we systematically seek to improve F49A-FTP by modifications in its three structural domains; we generated variants with (1) altered chemokine sequence (K14A, F49L, and F49E), (2) shortened and elongated linker region, and (3) modified toxin domain. Only F49L-FTP displayed higher selectivity in its binding to US28 versus CX3CR1, the endogenous receptor for CX3CL1, but this was not matched by a more selective killing of US28-expressing cells. A longer linker and different toxin variants decreased US28 affinity and selective killing. Thereby, F49A-FTP represents the best candidate for HCMV treatment. Many viruses encode internalizing receptors suggesting that not only HCMV but also, for instance, Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus may be targeted by FTPs.
Color hand gesture segmentation for images with complex background

The aim of this paper is to automatically segment the hand gesture from a given image under different luminance conditions and complex backgrounds. The luminance value affects the color component of an image which leads to increase the noise level in the segmented image. This paper proposes a combined model of two color spaces i.e., HSI, YCbCr and morphological operations with labeling to improve the segmentation performance of color hand gesture from complex backgrounds in terms of completeness and correctness. The proposed color model separates the chrominance and luminance components of the image. The performance of the proposed method is demonstrated through simulation and the experimental results reveal that proposed method provides better performance accuracy compared to the HSI and YCbCr methods individually in terms of correctness and completeness.
Probabilistic Iterative Expansion of Candidates in Mining Frequent Itemsets

A simple new algorithm is suggested for frequent itemset mining, using item probabilities as the basis for generating candidates. The method first finds all the frequent items, and then generates an estimate of the frequent sets, assuming item independence. The candidates are stored in a trie where each path from the root to a node represents one candidate itemset. The method expands the trie iteratively, until all frequent itemsets are found. Expansion is based on scanning through the data set in each iteration cycle, and extending the subtries based on observed node frequencies. Trie probing can be restricted to only those nodes which possibly need extension. The number of candidates is usually quite moderate; for dense datasets 2-4 times the number of final frequent itemsets, for non-dense sets somewhat more. In practical experiments the method has been observed to make clearly fewer passes than the well-known Apriori method. As for speed, our non-optimised implementation is in some cases faster, in some others slower than the comparison methods.
Testing Web Services : A Survey

The Service-Oriented Computing (SOC) paradigm is allowing computer systems to interact with each other in new ways. According to the literature, SOC allows composition of distributed applications free from their platform and thus reduces the cost of such compositions and makes them easier and faster to develop. Currently web services are the most widely accepted service technology due to the level of autonomy and platform-independency they provide. However, web services also bring challenges. For example, testing web services at the client side is not as straightforward as testing traditional software due to the complex nature of web services and the absence of source code. This paper surveys the previous work undertaken on web service testing, showing the strengths and weaknesses of current web service testing strategies and identifying issues for future work.
Multi-vehicles interaction graph model for cooperative collision warning system

Cooperative collision warning system for road vehicles, enabled by recent advances in positioning systems and wireless communication technologies, can potentially reduce traffic accident significantly. To improve the system, we propose a graph model to represent interactions between multiple road vehicles in a specific region and at a specific time. Given a list of vehicles in vicinity, we can generate the interaction graph using several rules that consider vehicle's properties such as position, speed, heading, etc. Safety applications can use the model to improve emergency warning accuracy and optimize wireless channel usage. The model allows us to develop some congestion control strategies for an efficient multi-hop broadcast protocol.
Large Scale Homophily Analysis in Twitter Using a Twixonomy

In this paper we perform a large-scale homophily analysis on Twitter using a hierarchical representation of users' interests which we call a Twixonomy. In order to build a population, community, or single-user Twixonomy we first associate "topical" friends in users' friendship lists (i.e. friends representing an interest rather than a social relation between peers) with Wikipedia categories. A word-sense disambiguation algorithm is used to select the appropriate wikipage for each topical friend. Starting from the set of wikipages representing "primitive" interests, we extract all paths connecting these pages with topmost Wikipedia category nodes, and we then prune the resulting graph G efficiently so as to induce a direct acyclic graph. This graph is the Twixonomy. Then, to analyze homophily, we compare different methods to detect communities in a peer friends Twitter network, and then for each community we compute the degree of homophily on the basis of a measure of pairwise semantic similarity. We show that the Twixonomy provides a means for describing users' interests in a compact and readable way and allows for a fine-grained homophily analysis. Furthermore, we show that midlow level categories in the Twixonomy represent the best balance between informativeness and compactness of the representation.
Analysis on the Timeliness of the Accountability Report by the Treasurer Spending in Task Force Units in Indonesia

This study aims to analyze the role of treasurer capacity on human resources and its tenure of services, facilities and infrastructures, the regulation, intensity of training administration and accountability of each of the task forces (SKPD) in North Sumatera on the timeliness of the regional government’s financial report. A total of 202 questionnaires were distributed in which 142 respondents by the general treasurers; receipts and spending of newly expanded regional governments in North Sumatera Province – Indonesia selected as the sample using the purposive random sampling method. The result of the study has revealed that simultaneously and partially the variables of treasurer’s human resources and tenure of service, facilities and infrastructure, the regulation and intensity of the training administration and the accountability of the treasurers in North Sumatera are significantly affect to the timeliness of the regional government’s financial report.
A parallel method for time discretization of parabolic equations based on Laplace transformation and quadrature

We consider the discretization in time of an inhomogeneous parabolic equation in a Banach space setting, using a representation of the solution as an integral along a smooth curve in the complex left half-plane which, after transformation to a finite interval, is then evaluated to high accuracy by a quadrature rule. This reduces the problem to a finite set of elliptic equations with complex coefficients, which may be solved in parallel. The paper is a further development of earlier work by the authors, where we treated the homogeneous equation in a Hilbert space framework. Special attention is given here to the treatment of the forcing term. The method is combined with finite-element discretization in spatial variables.
Steps towards a GENIA dependency treebank

In this paper we describe on-going work aimed at creating a dependency-based annotated treebank for the BioMedical domain. Our starting point is the GENIA corpus, which is a corpus of 2000 MEDLINE abstracts, which has been manually annotated for various biological entities, according to the GENIA Ontology. There is an exponential growth of published research in this sector, which makes it difficult even for the experts to follow the recent developments. This creates the need for tools that can automatically process the research literature and extract only relevant information, such as interactions between genes and proteins. In order for these tools to be developed, annotated resources, such as corpora and Treebanks are of fundamental importance. Such resources will support the development of practical domain-specific information extraction tools.
Research on Low Power Sigma-Delta Interface Circuit used in Capacitive Micro-accelerometers

Accelerometers have a wide range application in many fields, such as airbag deployment system and electronic stability control system in vehicles, and inertial navigation system in aircrafts and rockets. As Micro-Electro-Mechanical System (MEMS) technology advances, accelerometers are made smaller and smaller, often integrated in a single chip, with lower implementation costs and power consumptions. Modern MEMS accelerometers can be used in portable devices such as cell phones, RFID tags and even integrated in other sensors. This paper presents chip-level design and implementation of a second order sigma-delta interface circuit used in capacitive micro-accelerometers. The interface circuit provides 1-bit data stream and operates at a sampling frequency of 2.5MHz. The system model considers non-ideal factors in the circuit such as nonlinear distortion and noises. These non-ideal factors have been discussed through system level simulation in MATLAB. The micro-accelerometer, which is a highly integrated MEMS device, is then designed and implemented in silicon-on-insulator (SOI) substrate. Finally, the chip-level layout of interface circuit is implemented. Results have shown the chip with area of 1.32mm 2 and power consumption of about 5mW.
Norepinephrine regulation of cerebral glycogen utilization during seizures and ischemia

Norepinephrine (NE) depletion of the cerebral cortex after lesion of the ipsilateral locus ceruleus (LC) causes abnormalities of cerebral oxidative metabolism when the cortex is stimulated to increased energy demand (Harik, S. I., J. C. LaManna, A. I. Light, and M. Rosenthal (1979) Science 206: 69–71; LaManna, J. C. , S. I. Harik, A. I. Light, and M. Rosenthal (1981) Brain Res. 204: 87–101). These abnormalities were exhibited as decreased mitochondrial reducing equivalent flow. One possible cause of this would be the decreased availability of oxidative metabolic substrates in the NE-depleted cortex. We therefore investigated the effect of unilateral LC lesion and the resultant depletion of ipsilateral endogenous NE on glycogen and other energy metabolites in the cerebral cortex of rats under three conditions: (1) at “rest,” (2) when energy demand is inncreased markedly by seizures, and (3) during total cerebral ischemia. We report no differences in cerebral metabolites between NE-depleted and control hemispheres at "rest. " In seizures and ischemia, however, the increase in the level of adenosine 3′:5′-monophosphate (cyclic AMP) and the breakdown of glycogen were impaired considerably in the NE-depleted cortex. The data suggest that depletion of central NE impairs cerebral glycogenolysis in response to increased energy demands and ischemia. Such impairment may be mediated via a cyclic AMP-related mechanism.
Public value: conjecture and refutation, theory and ethics

This paper explores the theory of Public Value and the debate it has created in public management theory and practice. Public Value was first articulated by Mark Moore (1995). Scholars of public administration have argued, on the one hand, that Public Value can ‘solve the puzzle’ of ‘balancing democracy and efficiency’ in democracies (Stoker, 2006a; Wallis and Gregory, 2009) and on the other, that it constitutes a dangerous return to the justification for public managers as ‘Platonic guardians’ of political systems (Rhodes and Wanna, 2007). We argue that this debate neglects that Moore provides an ethical foundation for public managers to exercise autonomy in decision-making; thereby giving them a renewed legitimacy, importance and confidence when managing for unknowable futures.
Connectivity Coding: New Perspectives for Mesh Compression (Connectivity Coding: Neue Perspektiven für die Kompression von Dreiecksnetzen)

Compact encodings of the connectivity of planar triangulations is a very important subject not only in graph theory but also in computer graphics. For triangle meshes used in computer graphics the topologically planar regions dominate by far. New results by Isenburg et al. [6] even show that the connectivity is sufficient to describe shape by itself. Most coding methods for planar triangulations can be extended to manifolds of bounded genus with the same upper and lower bounds on the bit rate. In 1962 Tutte enumerated the number of different planar triangulations and his results show, that at least 3.245 bits per vertex are necessary to encode the connectivity graph of planar triangulations. In this article we improve the so far best upper bound [5] and show that the connectivity of a planar triangulation can be encoded with less than 3.525 bits per vertex, while ensuring a linear run time for encoding and decoding.
Simultaneous Equations in the Markov-Switching Model

In this paper, Hamilton’s (1989) Markov-switching model is extended to the simultaneous equations model. Using a framework for an instrumental variable interpretation of full information maximum likelihood (FIML) by Hausman (1975), we can deal with the problem of simultaneous equations based on the Hamilton filter. When we compared the proposed FIML Markov-switching model to LIML Markovswitching models such as Kim (2004a), Spagnolo, F. , Psaradakis, Z. , and Sola, M. (2005), we found that LIML Markov-switching models are a special case of the proposed FIML Markov-switching model where all but the first equation are just identified. Moreover, the proposed FIML Markov-switching model is a general form in the simultaneous equations and covers a broad class of models that could not be handled before. As we applied the proposed model to Campbell and Mankiw’s (1989) consumption function, by allowing for possibilities of structural breaks in the sensitivity of consumption growth to income growth, we can assume a marginal propensity to consumption β constant because the difference between 0 β and 1 β is very small. JEL classification: C13; C32 Keyword: full information maximum likelihood estimation, FIML, LIML, instrumental variable, simultaneous equation, Markov switching, Hamilton filter, consumption 1 POSCO Research Institute, POSRI, 147, Samsung-dong, Gangnam-gu, Seoul 135-878, Korea Phone: +82-2-3457-8228; fax: +82-2-3457-8040. E-mail: jhyoon@posri.re. kr
Common Correlated Effects Estimation of Dynamic Panels with Cross-Sectional Dependence

We derive inconsistency expressions for dynamic panel data estimators under error cross-sectional dependence generated by an unobserved common factor in both the fixed effect and the incidental trends case. We show that for a temporally dependent factor, the standard within groups (WG) estimator is inconsistent even as both N and T tend to infinity. Next we investigate the properties of the common correlated effects pooled (CCEP) estimator of Pesaran (2006) which eliminates the error cross-sectional dependence using cross-sectional averages of the data. In contrast to the static case, the CCEP estimator is only consistent when next to N also T tends to infinity. It is shown that for the most relevant parameter settings, the inconsistency of the CCEP estimator is larger than that of the infeasible WG estimator, which includes the common factors as regressors. Restricting the CCEP estimator results in a somewhat smaller inconsistency. The small sample properties of the various estimators are analyzed using Monte Carlo experiments. The simulation results suggest that the CCEP estimator can be used to estimate dynamic panel data models provided T is not too small. The size of N is of less importance.
Bias in Jurors vs Bias in Juries: New Evidence from the SDS Perspective.

Prior research by Kaplan and Miller (1978) suggested that juries are generally influenced less by extralegal, biasing information than individual jurors are. A social decision scheme (SDS) analysis of this question by Kerr, MacCoun, and Kramer (1997) suggested (a) that Kaplan and Miller's conclusion should hold only for relatively extreme legal cases (i.e., cases where the probability of conviction, without biasing information, was either very high or very low) and (b) that the opposite pattern should hold for moderate cases (with moderate conviction rates)-i.e., juries should show even greater sensitivity to biasing information than should individual jurors. An experiment is reported that compared juror vs jury sensitivity to biasing information (viz., prejudicial pretrial publicity) for versions of a legal case with a moderate and an extreme conviction rate. Consistent with the SDS analysis, juries were more biased than jurors for the moderate-case version, but the reverse was true for the extreme-case version. The implications of these findings and the more general utility of the SDS model for studying group processes are discussed. Copyright 1999 Academic Press.
Location always matters: How to improve performance of dynamic networks?

IN OUR talk we will focus on networks with no predefined infrastructure (ad-hoc networks, sensor networks, vehicular networks). There are many optimization problems derived from the context of such networks including power assignment mechanisms, scheduling, data gathering, etc. We will discuss various techniques tacking these problems emphasizing the importance of mobile nodes locations and its influence on the tightness of the solutions.
Modeling, identification, and control of large-scale dynamical systems

This paper highlights some fundamental issues involved in the study of large-scale dynamical systems. Two particular topics are discussed in some detail, one dealing with the management of active sensors via partially observable Markov decision processes, and the other dealing with the modeling, recognition and tracking of multi-function radars in an electronic warfare environment.
Lightweight LCP-Array Construction in Linear Time

The suffix tree is a very important data structure in string processing, but it suffers from a huge space consumption. In large-scale applications, compressed suffix trees (CSTs) are therefore used instead. A CST consists of three (compressed) components: the suffix array, the LCP-array, and data structures for simulating navigational operations on the suffix tree. The LCP-array stores the lengths of the longest common prefixes of lexicographically adjacent suffixes, and it can be computed in linear time. In this paper, we present new LCP-array construction algorithms that are fast and very space efficient. In practice, our algorithms outperform the currently best algorithms.
The Social Perception of Heroes and Murderers: Effects of Gender-Inclusive Language in Media Reports

The way media depict women and men can reinforce or diminish gender stereotyping. Which part does language play in this context? Are roles perceived as more gender-balanced when feminine role nouns are used in addition to masculine ones? Research on gender-inclusive language shows that the use of feminine-masculine word pairs tends to increase the visibility of women in various social roles. For example, when speakers of German were asked to name their favorite “heroine or hero in a novel,” they listed more female characters than when asked to name their favorite “hero in a novel. ” The research reported in this article examines how the use of gender-inclusive language in news reports affects readers’ own usage of such forms as well as their mental representation of women and men in the respective roles. In the main experiment, German participants (N = 256) read short reports about heroes or murderers which contained either masculine generics or gender-inclusive forms (feminine-masculine word pairs). Gender-inclusive forms enhanced participants’ own usage of gender-inclusive language and this resulted in more gender-balanced mental representations of these roles. Reading about “heroines and heroes” made participants assume a higher percentage of women among persons performing heroic acts than reading about “heroes” only, but there was no such effect for murderers. A post-test suggested that this might be due to a higher accessibility of female exemplars in the category heroes than in the category murderers. Importantly, the influence of gender-inclusive language on the perceived percentage of women in a role was mediated by speakers’ own usage of inclusive forms. This suggests that people who encounter gender-inclusive forms and are given an opportunity to use them, use them more themselves and in turn have more gender-balanced mental representations of social roles.
QMDD: A Decision Diagram Structure for Reversible and Quantum Circuits

In this paper, we present a novel structure, QuantumMultiple- valued Decision Diagrams (QMDD), specifically designed to represent and manipulate the matrices encountered in the specification of reversible and quantum gates and circuits, both binary and multiple-valued. QMDD use many common decision diagram techniques, ideas introduced in QuIDDPro and novel techniques introduced here. Building the QMDD for the matrices for individual gates and the subsequent construction of the QMDD for the matrix describing a circuit are discussed. A prototype C implementation is described and experimental results are given that show the new structure is a promising and compact representation for reversible and quantum logic circuits.
Bandwidth monitoring for network-aware applications

Network-aware content delivery is an attractive approach to mitigate the problems produced by the significant fluctuations of the available bandwidth present in today's Internet. Such network-aware applications require information about the current condition of the network to adapt their resource demands. Such information can be obtained at the network level, the transport protocol level, or directly by the application. This paper compares two kinds of application-level monitoring (at the sender and receiver side) and transport-level monitoring with regard to their ability to provide useful information to network-aware applications. The results indicate that transport-level monitoring can effectively and efficiently satisfy the need for timely and accurate bandwidth information. This observation has direct implications for protocol/OS design. It is desirable to widen the transport layer API to allow the application efficient access to network status information required for adaptation.