Miracle-dz/UniFAR-FTUs huggingface dataset:
Gruppentherapie für somatoforme Störungen – Behandlungsleitfaden, Akzeptanz und Prozessqualität

Group Therapy for Somatoform Disorders: Treatment Guidelines, Acceptance, and Process Quality Background: Patients with multiple and chronified somatoform symptoms are difficult to treat in psychotherapeutic settings. Therefore a group intervention has been developed. The acceptability and parts of the process quality are analyzed. Patients and Method: 107 patients with somatization syndrome (at least 8 physical symptoms) were treated in an inpatient setting with an integrative behavioral-cognitive approach. They received an additional standardized group therapy (‘Soma group’) to modify attributions and to develop coping strategies for the symptoms. After each of the 8 group therapy sessions, evaluation questionnaires were filled out. These process data were correlated with baseline data on symptomatology, psychotherapy motivation and outcome data of the 1-year follow-up. Results: The group intervention was highly accepted. More than 90% of patients stayed in therapy and filled out the questionnaires. While the ratings for the first session are medium, from the 2nd session forward ratings are very positive (above 4 on a 1–5 scale) and continuously improve. The initial number of somatoform symptoms only has a small influence on treatment satisfaction. Motivation for psychotherapy at the beginning has no substantial impact, indicating that patients without psychotherapy motivation can develop satisfaction with the treatment as well. Process data on treatment satisfaction are associated with general treatment satisfaction and symptom reduction 1 year later. Discussion: The group intervention seems to be an economic and highly accepted way to develop motivation for psychological treatments in somatoform disorders.
A hybrid approach for a constrained routing problem

Regarding the solution of combinatorics problems, is important to evaluate the cost and the benefit among obtaining solutions of high quality in detriment of the computational resources required. The problem presented is about the routing of a vehicle with pickup and delivery of product with time window constraints. This problem requires to be attended with instances of great scale (nodes/spl ges/100). We have a large quantity of nodes with restrictions of time windows (/spl ges/90%) and with a large factor of amplitude (/spl ges/75%) as well. The problem is NP-hard and for such motive the application of an exact method of solution to resolve it, is limited by the practical time for routing. This paper proposes a specialized genetic algorithm, which offers solutions of good quality in computational times that do useful its application.
Implementation of a Wide-Coverage Tactical Generator for TurkishDilek

In this paper, we present the design and implementation of a tactical generator for Turkish, a free constituent order language, in which the order of the constituents may change according to the information structure of the sentences to be generated. In the absence of any information regarding the information structure of a sentence (i.e., topic, focus, background, etc.), the constituents of the sentence obey a default order, but the order is almost freely changeable, depending on the constraints of the text ow or discourse. We have used a recursively structured nite state machine (implemented as a right-linear grammar backbone) for handling the changes in constituent order. Morphological realization has been implemented using an external morphological analysis component which performs concrete morpheme selection and handles morphographemic processes.
K-ras codon 12 and not TP53 mutations are predominant in advanced colorectal cancers

Background. Colorectal cancer (CRC) is one of the most common types of cancer, affecting 3 - 5% of the global population. K-ras protooncogene and TP53 tumour suppressor gene mutations are among the most common genetic alterations detected in advanced colorectal tumours. Objective. To investigate the role of K-ras codon 12 and TP53 exons 5 - 9 mutations in late-stage CRC patients. Methods. Blood samples were collected from 249 CRC patients, of whom 147 presented with advanced carcinoma. K-ras codon 12 mutations were analysed using polymerase chain reaction-restriction fragment length polymorphism, while direct sequencing was used in screening for TP53 exons 5 - 9 mutations. Results. No significant changes were observed in TP53 exons 5 - 9, except for two cases in which nucleotide replacements were observed in the non-coding regions in intron 4 (c.376-19C>T) and intron 9 (c.993+12T>C). Heterozygous mutations in K-ras codon 12 were observed in 79 individuals suffering from advanced CRC (53.7%). Colon and rectal tumours were equally distributed among the heterozygotes, but colon tumours were mostly present in wild-type homozygotes (84.6%). There was also a predominance of Caucasians among heterozygotes and a predominance of Asians among the wild-type homozygotes. Conclusion. Analysis of peripheral blood samples of CRC patients suffering from advanced carcinoma has prognostic value only for K-ras codon 12 mutations, and not for TP53 mutations.
Multiplicity of Galactic Cepheids from long-baseline interferometry – III. Sub-percent limits on the relative brightness of a close companion of δ Cephei

We report new CHARA/MIRC interferometric observations of the Cepheid archetype $\delta$ Cep, which aimed at detecting the newly discovered spectroscopic companion. We reached a maximum dynamic range $\Delta H $ = 6.4, 5.8, and 5.2 mag, respectively within the relative distance to the Cepheid $r 9.15, 8.31$ and 7.77 mag, respectively for $r < 25$ mas, $25 < r < 50$ mas and $50 < r < 100$ mas. We also found that to be consistent with the predicted orbital period, the companion has to be located at a projected separation $< 24$ mas with a spectral type later than a F0V star.
Comprehensive Sequence Analysis of the Human IL23A Gene Defines New Variation Content and High Rate of Evolutionary Conservation

A newly described heterodimeric cytokine, interleukin-23 (IL-23) is emerging as a key player in both the innate and the adaptive T helper (Th)17 driven immune response as well as an initiator of several autoimmune diseases. The rate-limiting element of IL-23 production is believed to be driven by expression of the unique p19 subunit encoded by IL23A. We set out to perform comprehensive DNA sequencing of this previously under-studied gene in 96 individuals from two evolutionary distinct human population groups, Southern African Bantu and European. We observed a total of 33 different DNA variants within these two groups, 22 (67%) of which are currently not reported in any available database. We further demonstrate both inter-population and intra-species sequence conservation within the coding and known regulatory regions of IL23A, supporting a critical physiological role for IL-23. We conclude that IL23A may have undergone positive selection pressure directed towards conservation, suggesting that functional genetic variants within IL23A will have a significant impact on the host immune response.
Attachment style and alliance in patients with diabetes and healthcare professionals

Avoidant attachment has been found to impair attendance at appointments and treatment adherence of patients with diabetes, but the role of staff–patient relationships has not been explored. This study investigates whether attachment influences the quality of alliance between patients with diabetes and healthcare professionals. Patient avoidance was significantly associated with difficulties in therapeutic alliance. Further research is required to establish whether therapeutic alliance, underpinned by attachment, influences treatment adherence and to investigate ways of promoting collaboration.
Direct Activation of b-Cell KATP Channels with a Novel Xanthine Derivative s

ATP-regulated potassium (KATP) channel complexes of inward rectifier potassium channel (Kir) 6.2 and sulfonylurea receptor (SUR) 1 critically regulate pancreatic islet b-cell membrane potential, calcium influx, and insulin secretion, and consequently, represent important drug targets for metabolic disorders of glucose homeostasis. The KATP channel opener diazoxide is used clinically to treat intractable hypoglycemia caused by excessive insulin secretion, but its use is limited by off-target effects due to lack of potency and selectivity. Some progress has been made in developing improved Kir6.2/SUR1 agonists from existing chemical scaffolds and compound screening, but there are surprisingly few distinct chemotypes that are specific for SUR1-containing KATP channels. Here we report the serendipitous discovery in a highthroughput screen of a novel activator of Kir6.2/SUR1: VU0071063 [7-(4-(tert-butyl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione]. The xanthine derivative rapidly and dose-dependently activates Kir6.2/SUR1 with a half-effective concentration (EC50) of approximately 7mM, is more efficacious than diazoxide at lowmicromolar concentrations, directly activates the channel in excised membrane patches, and is selective for SUR1over SUR2A-containing Kir6.1 or Kir6.2 channels, as well as Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2, and voltage-gated potassium channel 2.1. Finally, we show that VU0071063 activates native Kir6.2/SUR1 channels, thereby inhibiting glucose-stimulated calcium entry in isolated mouse pancreatic b cells. VU0071063 represents a novel tool/compound for investigating b-cell physiology, KATP channel gating, and a new chemical scaffold for developing improved activators with medicinal chemistry.
How Viral Are Viral Videos?

Within only a few years after the launch of video sharing platforms, viral videos have become a pervasive Internet phenomenon. Yet, notwithstanding growing scholarly interest, the suitability of the viral metaphor seems not to have been studied so far. In this paper, we therefore investigate the attention dynamics of viral videos from the point of view of mathematical epidemiology. We introduce a novel probabilistic model of the progression of infective diseases and use it to analyze time series of YouTube view counts and Google searches. Our results on a data set of almost 800 videos show that their attention dynamics are indeed well accounted for by our epidemic model. In particular, we find that the vast majority of videos considered in this study show very high infection rates.
Observational semantics of the Prolog Resolution Box Model

This paper specifies an observational semantics and gives an original presentation of the Byrd box model. The approach accounts for the semantics of Prolog tracers independently of a particular Prolog implementation. Prolog traces are, in general, considered as rather obscure and difficult to use. The proposed formal presentation of its trace constitutes a simple and pedagogical approach for teaching Prolog or for implementing Prolog tracers. It is a form of declarative specification for the tracers. The trace model introduced here is only one example to illustrate general problems relating to tracers and observing processes. Observing processes know, from observed processes, only their traces. The issue is then to be able to reconstitute, by the sole analysis of the trace, part of the behaviour of the observed process, and if possible, without any loss of information. As a matter of fact, our approach highlights qualities of the Prolog resolution box model which made its success, but also its insufficiencies.
Immunosuppressive agents for treating IgA nephropathy.

BACKGROUND IgA nephropathy (IgAN) is a world-wide disease and the cause of end-stage renal failure (ESRF) in 15 to 20% of patients within 10 years and in 30 to 40% of individuals within 20 years from the apparent onset of disease. No specific treatment has yet been established but many approaches have been investigated. OBJECTIVES To assess the benefits and harms of immunosuppressive treatment for IgAN. SEARCH STRATEGY We searched The Cochrane Renal Group's specialized register (May 2003), Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 3, 2002) MEDLINE (1966 - September 2002), EMBASE (1988 - September 2002) and handsearched reference lists of retrieved articles and conference proceedings. SELECTION CRITERIA Randomized controlled trials (RCTs) and quasi-RCTs comparing treatment of IgAN with immunosuppressive agents against placebo, no treatment, other immunosuppressive or non-immunosuppressive agents. DATA COLLECTION AND ANALYSIS Two reviewers independently assessed trial quality and extracted data. Statistical analyses were performed using the random effects model and the results expressed as relative risk (RR) for dichotomous outcomes and weighted mean difference (WMD) for continuous outcomes, with 95% confidence intervals (CI). MAIN RESULTS Thirteen eligible RCTs involving 623 patients were identified. All identified RCTs had a placebo, no treatment or warfarin/dipyridamole control group. Seven trials used steroids, three used alkylating agents/cyclosporin and three used combinations of steroids and alkylating agents/cyclosporin. No trial directly compared steroids versus alkylating agents/cyclosporin. Quality was sub-optimal. Steroids were associated with a lower risk of progression to ESRF (RR 0.44, 95% CI 0.25 to 0.80) and lower urinary protein excretion (WMD -0.49 g/24h, 95% CI -0.72 to -0.12). Urinary protein excretion was lower for patients treated with alkylating agents/cyclosporin compared to placebo/no treatment (WMD -0.94 g/24h, 95% CI -1.43 to -0.46). There was no significant reduction of urinary protein excretion with combination treatment of steroids and alkylating agents compared with placebo/no treatment. REVIEWER'S CONCLUSIONS The optimal management of IgAN remains uncertain. The RCTs identified were small, of sub-optimal methodological quality and tended to only report favorable and surrogate outcomes without a thorough reporting of treatment harms. All outcomes favor the use of immunosuppressive interventions, with steroids appearing to be the most promising. Further study, in the form of RCTs, is necessary to ascertain which patients would benefit from these interventions, whether they are the ones with early signs of renal dysfunction or those with more advanced renal impairment.
Golden Parachutes: CEOs and the Exercise of Social Influence

The authors gratefully acknowledge the helpful criticisms and comments of Peter Cappelli, Glenn Carroll, Heather Haveman, David Levine, Brian Main, Trond Petersen, and the anonymous reviewers on an earlier version of this manuscript and the Institute of Industrial Relations and the Center for Research in Management for research support. Using an agency theory framework and data on 89 Fortune 500 firms, we assess whether the granting of golden parachutes to chief executive officers is the result of an economically rational process or determined by the social influence of the CEO. While increased takeover risk is associated with a higher incidence of GPs, as predicted by economic theory, CEOs who are able to appoint more outsiders to their board are also more likely to have GPs. These results suggest that both economic and social influence perspectives have merit and that the importance of each may depend on the ownership structure of the fi rm. -
Automatic Discovery of Related Concepts

This report describes an Information Discovery tool, which is designed to help users with finding relevant information regarding the goals they intend to achieve. This information is extracted from an input corpus and organized into a knowledge graph. The knowledge graph is created by extracting informative entities and the relations connecting them to one another. The architecture of this system and a description of different phases and implemented components follow.
The Father-Adolescent Relationship in the Context of the Mother-Adolescent Relationship

This study examined father and mother linkages in relation to adolescent academic and athletic competence and self-worth. A total of 140 Singapore undergraduates reported on themselves and their parents. Results indicate that some links between father characteristics and adolescent attributes exist only when mother characteristics are considered. The link between father responsiveness and athletic competence existed only when mother responsiveness was high, and that link between father acceptance of individuation and athletic competence existed only when mother acceptance of individuation was moderate or high. Results also indicate that father characteristics moderate links between mother characteristics and adolescent attributes. The link between mother responsiveness and self-worth became stronger as father responsiveness increased. These findings demonstrate the need to consider both parents' characteristics together rather than independently or exclusively.
Notice of RetractionResearch of PV Model and MPPT Methods in Matlab

The power generated by the PV generator depends on the irradiance, temperature, and surface conditions. The PV generator has a nonlinear characteristic, and the power has a maximum power point or multi-local maximum power points under different conditions. Various MPPT methods have been reported, in order to confirm the effectiveness of each control method, experimental or simulation analysis is used, from economical point of view, simulation analysis is more effective. In this paper, a versatile, accurate Matlab/Simulink PV model suitable for use by power electronics specialists has been developed, and has been designed for easy implementation on Matlab/Simulink platform; conventional MPPT methods and MPPT methods suitable for partial shading conditions can be simulated by using this PV model.
Advances in the Medical Treatment of Malignant Mesothelioma

Malignant Pleural Mesothelioma (MPM) is a highly lethal and refractory malignancy that is caused by asbestos exposure. Surgical resection, radiotherapy, and other local treatments are of limited efficacy. Therefore, systemic chemotherapy plays an important role in improving of treatment outcomes for MPM. The findings of a largescale phase III study led to the approval of a novel antifolate, pemetrexed, by the U.S. Food and Drug Administration (FDA), making pemetrexed the world’s first therapeutic agent for MPM. Further, the combination treatment of pemetrexed plus cisplatin has been recognized as standard chemotherapy for this disease in the first-line setting. Recent studies have provided evidence that second-line chemotherapy is associated with prolonged survival among patients with various malignancies, including MPM. To date, however, no chemotherapeutic regimens have been recommended for MPM in the second-line setting. Furthermore, although, systemic chemotherapy is carried out in the majority of medical cases of MPM, it has not been established whether this systemic chemotherapy contributes to prolonged survival. This article reviews the latest findings regarding chemotherapy in cases of MPM and focuses on new medical treatments including molecular targeted therapies.
Burst muscle performance predicts the speed, acceleration, and turning performance of Anna’s hummingbirds

Despite recent advances in the study of animal flight, the biomechanical determinants of maneuverability are poorly understood. It is thought that maneuverability may be influenced by intrinsic body mass and wing morphology, and by physiological muscle capacity, but this hypothesis has not yet been evaluated because it requires tracking a large number of free flight maneuvers from known individuals. We used an automated tracking system to record flight sequences from 20 Anna's hummingbirds flying solo and in competition in a large chamber. We found that burst muscle capacity predicted most performance metrics. Hummingbirds with higher burst capacity flew with faster velocities, accelerations, and rotations, and they used more demanding complex turns. In contrast, body mass did not predict variation in maneuvering performance, and wing morphology predicted only the use of arcing turns and high centripetal accelerations. Collectively, our results indicate that burst muscle capacity is a key predictor of maneuverability. DOI: http://dx.doi. org/10.7554/eLife.11159. 001
The Potential and Challenges of siRNA-Based Targeted Therapy for Treatment of Patients with Glioblastoma

M. Verreault1,3,*, S. Yip3,4, B. Toyota5 and M.B. Bally1,2,3 1Experimental Therapeutics, British Columbia Cancer Agency, Vancouver, BC 2Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, 3Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, 4Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, 5Division of Neurosurgery, British Columbia Cancer Agency,Vancouver, BC Canada
Spatial and temporal variation in otolith chemistry of tautog ( Tautoga onitis )

REVIEW COPY The dependence of fish production and population dynamics on dispersal and migration among multiple habitats, referred to as “connectivity,” is a critical property of marine populations. Connectivity rates determine colonization patterns for new habitats, the resiliency of populations to harvest, and can be used in the design of marine protected areas (MPAs). Quantifying connectivity rates in marine organisms is, however, extremely diffi cult because the natal and nursery origins of adults are almost unknown. Recently, tagging techniques with natural isotopic and elemental markers have been developed for species that were not able to be tagged or recaptured by conventional approaches. Chemical natural habitat tags in the otoliths of juvenile fi sh have been used to differentiate individuals from different estuarine and riverine systems (Thorrold et al., 1998a; Thorrold et al., 1998b; Gillanders and Kingsford, 2000; Gillanders, 2002b) and other types of nearshore habitats, such as estuary as opposed to rocky reef (Gillanders and Kingsford, 1996) and estuary as opposed to Spatial and temporal variation in otolith chemistry of tautog (Tautoga onitis)
Characterizing Avian Escherichia coli Isolates with Multiplex Polymerase Chain Reaction

Abstract SUMMARY. Colibacillosis caused by Escherichia coli infections account for significant morbidity and mortality in the poultry industry. Yet, despite the importance of colibacillosis, much about the virulence mechanisms employed by avian E. coli remains unknown. In recent years several genes have been linked to avian E. coli virulence, many of which reside on a large transmissible plasmid. In the present study, a multiplex polymerase chain reaction (PCR) protocol to detect the presence of four of these genes is described. Such a protocol may supplement current diagnostic schemes and provide a rapid means of characterizing the E. coli causing disease in poultry. The targets of this procedure included iss, the increased serum survival gene; tsh, the temperature sensitive hemagglutinin gene; cvi, the ColV immunity gene; and iucC, a gene of the aerobactin operon. Organisms, known for their possession or lack of these genes, were used as a source of the template DNA to develop the multiplex PCR protocol. Identity of the amplicons was confirmed by size, DNA:DNA hybridization with specific gene probes, and DNA sequencing. When the multiplex PCR protocol was used to characterize 10 E. coli isolates incriminated in avian colibacillosis and 10 from the feces of apparently healthy birds, nine of the isolates from apparently healthy birds contained no more than one gene, while the 10th contained all four. Also, eight of the isolates incriminated in colibacillosis contained three or more genes, while the remaining two contained two of the target genes. Interestingly, the isolates of sick birds containing only two of the targeted genes killed the least number of embryos, and the isolate of healthy birds that contained all the genes killed the most embryos among this group. These genes were not found among the non–E. coli isolates tested, demonstrating the procedure's specificity for E. coli. Overall, these results suggest that this protocol might be useful in characterization and study of avian E. coli.