Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapeutic nursing care: transition in sexuality of the elderly caregiving spouse.

Objective To understand the transitions experienced, and the conditions and expected response patterns to changes in sexuality of the spouse-caregiver of the elderly, during progression of the dementia process. Method A qualitative research study, conducted at the neurogeriatric clinic between May of 2014 and May of 2015. An intensive, individual interview was administered to 12 elderly caregivers. Thematic content analysis was applied, using the theoretical model of Transition Theory. Results Seven categories emerged, involving relationship and conjugal sexuality; disease repercussions; care and professional approach; attitudes, beliefs and social imagery of sexuality and care; family relationship and redefining of sexuality. Final considerations Family development and marital life, the aspects of formation and development of sexuality, the specifics that involved living and caring for the other were understood, with successive events and changes influenced by old age, dementia, beliefs and social imagery.
Contribution of Impaired Muscle Glucose Clearance to Reduced Postabsorptive Systemic Glucose Clearance in NIDDM

The reduced postabsorptive rates of systemic glucose clearance in non-insulin-dependent diabetes mellitus (NIDDM) are thought to be the consequence of insulin resistance in peripheral tissues. Although the peripheral tissues involved have not been identified, it is generally assumed to be primarily muscle, the major site of insulin-mediated glucose disposal. To test this hypothesis, we measured postabsorptive systemic and forearm glucose utilization and clearance in 15 volunteers with NIDDM and 15 age- and weightmatched nondiabetic volunteers. Although systemic glucose utilization was increased in NIDDM subjects (14.5 ± 0.5 vs. 11.2 ± 0.2 μmol · kg−1 · min−1, P < 0.001), systemic glucose clearance was reduced 1.40 ± 0.06 vs. 2.13 ± 0.05 ml · kg−1 · min−1, P < 0.01). Although forearm glucose utilization was increased in NIDDM subjects (0.663 ± 0.058 vs. 0.411 ± 0.019 μmol · dl−1 · min−1, P < 0.001), forearm glucose dl−1 clearance was reduced (0.628 ± 0.044 vs. 0.774 ± 0.037 ml · L−1 · min−1, P < 0.01). However, extrapolation of forearm data to total-body muscle indicated that impaired clearance reduced muscle glucose disposal by only 61 ± 21 μmol<min, whereas impaired systemic clearance reduced systemic glucose disposal by 662 ± 82 μmol<min. Thus, impaired muscle glucose clearance accounted for <10% of the reduced systemic glucose clearance in NIDDM subjects. Therefore, we conclude that muscle insulin resistance plays only a minor role in the reduced systemic glucose clearance found in NIDDM in the postabsorptive state and propose that reduced brain glucose clearance is largely responsible.
Mutation screening of the ubiquitin ligase gene RNF135 in French patients with autism

Many genes are now thought to confer susceptibility to autism. Despite the fact that this neuropsychiatric disease appears to be related to several different causes, common cellular and molecular pathways have emerged and point to synaptic dysfunction or cellular growth. Several studies have indicated the importance of the ubiquitin pathway in synaptic function and the aetiology of autism. Here, we focused on the ring finger protein 135 (RNF135) gene, encoding an E3 ubiquitin ligase expressed in the cortex and cerebellum, and located in the NF1 gene locus in 17q11.2, a region linked to autism. We carried out a genetic analysis of the coding sequence of RFN135 in a French cohort of patients with autism and observed a significantly increased frequency of genotypes carrying the rare allele of the rs111902263 (p.R115K) missense variant in patients (P=0.0019, odds ratio: 4.23, 95% confidence interval: 1.87–9.57). Particularly, three unrelated patients showed a homozygous genotype for K115, a situation not observed in the 1812 control individuals. Further cellular and molecular studies are required to elucidate the role of this gene and the variant K115 in brain development and neuronal function.
Component level prediction versus system level measurement of SABER relative spectral response

A 10-channel infrared (1.25-17.24 µm wavelength) radiometer known as SABER (Sounding of the Atmosphere using Broadband Emission Radiometry) is one of four experiments that will fly on the TIMED (Thermosphere, Ionosphere, Mesosphere, Energetics, and Dynamics) mission that was successfully launched on 7 December 2001. Theoretical models of the relative spectral response (RSR) for each SABER channel were developed during the design and build of the instrument. The RSR calculations were then refined using a component level technique where theoretical predictions of filter transmittance were replaced with measurements from filter witness samples. During SABER ground calibration, full system measurements of RSR were performed using a Michelson step-scan interferometer to present an interferometrically modulated infrared source to the instrument with the resultant interferogram recorded by the instrument detectors. Fourier transform of this interferogram and correction of the resulting spectrum for the spectral output of the interferometer and the transmittance of any intervening optics provide a measurement of the system level RSR. We compare the full system level measurements with the theoretical and component level RSR predictions for both in-band and out-of-band spectral regions. Our results show that the system level method for determining RSR provides the clearest picture of the instrument's spectral properties.
Efectos del envejecimiento de la población sobre el ahorro

ANALISIS DE LAS CONSECUENCIAS ECONOMICAS DEL ENVEJECIMIENTO DE LA POBLACION, FUNDAMENTALMENTE SOBRE EL AHORRO. PARA ELLO, EN PRIMER LUGAR SE REVISAN LAS TEORIAS DEL COMPORTAMIENTO DEL CONSUMIDOR, CON ESPECIAL REFERENCIA A LOS MAYORES DE 65 ANOS. EN SEGUNDO LUGAR, SE CONTRASTA EMPIRICAMENTE EL COMPORTAMIENTO AHORRADOR DE LOS MAYORES DE 65 ANOS EN ESPANA, COMPARANDOLO CON EL RESTO DE LA POBLACION. SE ANALIZA TAMBIEN -EL PAPEL DEL AHORRO COLOCADO EN SISTEMAS DE PREVISION PRIVADOS: LA SUSTITUIBILIDAD DEL MISMO CON OTRAS FORMAS DE AHORRO Y SU POSIBLE PAPEL EN LA CRISIS FINANCIERA DE LA SEGURIDAD SOCIAL, DEBIDA AL ENVEJECIMIENTO DE LA POBLACION. PARA ESTE ULTIMO ANALISIS SE UTILIZA INSTRUMENTAL TEORICO Y SE HACE, TAMBIEN, ALGUN ANALISIS EMPIRICO.
Characterizing Types of Convolution in Deep Convolutional Recurrent Neural Networks for Robust Speech Emotion Recognition

Deep convolutional neural networks are being actively investigated in a wide range of speech and audio processing applications including speech recognition, audio event detection and computational paralinguistics, owing to their ability to reduce factors of variations, for learning from speech. However, studies have suggested to favor a certain type of convolutional operations when building a deep convolutional neural network for speech applications although there has been promising results using different types of convolutional operations. In this work, we study four types of convolutional operations on different input features for speech emotion recognition under noisy and clean conditions in order to derive a comprehensive understanding. Since affective behavioral information has been shown to reflect temporally varying of mental state and convolutional operation are applied locally in time, all deep neural networks share a deep recurrent sub-network architecture for further temporal modeling. We present detailed quantitative module-wise performance analysis to gain insights into information flows within the proposed architectures. In particular, we demonstrate the interplay of affective information and the other irrelevant information during the progression from one module to another. Finally we show that all of our deep neural networks provide state-of-the-art performance on the eNTERFACE'05 corpus.
Residual-Guided Look-Ahead in AND/OR Search for Graphical Models

We introduce the concept of local bucket error for the mini-bucket heuristics and show how it can be used to improve the power of AND/OR search for combinatorial optimization tasks in graphical models (e.g. MAP/MPE or weighted CSPs). The local bucket error illuminates how the heuristic errors are distributed in the search space, guided by the mini-bucket heuristic. We present and analyze methods for compiling the local bucket-errors (exactly and approximately) and show that they can be used to yield an effective tool for balancing look-ahead overhead during search. This can be especially instrumental when memory is restricted, accommodating the generation of only weak compiled heuristics. We illustrate the impact of the proposed schemes in an extensive empirical evaluation for both finding exact solutions and anytime suboptimal solutions.
Implementing ERP in China: Lessons from family-owned Chinese enterprises

Enterprise resource planning (ERP) systems is one of the most popular organisation-wide software packages to emerge in recent years, mainly because of the benefits of successful implementation that a wide range of businesses can experience. This paper adopts a case study approach to examine the ERP implementation experiences of two family-owned Chinese enterprises. Relatively new to Chinese enterprises, and not easily accepted in smaller family-owned businesses, ERP uptake is, in general, on the increase as Chinese enterprises look towards this system to help them modernise their business, and enact change in their management model. The major findings of this paper are that the success factors for ERP implementation in family-owned Chinese enterprises is fundamentally the same as that of other Chinese enterprises provided a key champion is in place. Furthermore, the success factors are fundamentally the same as those found in Western enterprises, as long as Chinese cultural characteristics are considered.
The ABILHAND Questionnaire as a Measure of Manual Ability in Chronic Stroke Patients: Rasch-Based Validation and Relationship to Upper Limb Impairment

Background and Purpose— Chronic hemiparetic patients often retain the ability to manage activities requiring both hands, either through the use of the affected arm or compensation with the unaffected limb. A measure of this overall ability was developed by adapting and validating the ABILHAND questionnaire through the Rasch measurement model. ABILHAND measures the patient’s perceived difficulty in performing everyday manual activities. Methods— One hundred three chronic (>6 months) stroke outpatients (62% men; mean age, 63 years) were assessed (74 in Belgium, 29 in Italy). They lived at home and walked independently and were screened for the absence of major cognitive deficits (dementia, aphasia, hemineglect). The patients were administered the ABILHAND questionnaire, the Brunnström upper limb motricity test, the box-and-block manual dexterity test, the Semmes-Weinstein tactile sensation test, and the Geriatric Depression Scale. The brain lesion type and site were recorded. ABILHAND results were analyzed with the use of Winsteps Rasch software. Results— The Rasch refinement of ABILHAND led to a change from the original unimanual and bimanual 56-item, 4-level scale to a bimanual 23-item, 3-level scale. The resulting ability scale had sufficient sensitivity to be clinically useful. Rasch reliability was 0.90, and the item-difficulty hierarchy was stable across demographic and clinical subgroups. Grip strength, motricity, dexterity, and depression were significantly correlated with the ABILHAND measures. Conclusions— The ABILHAND questionnaire results in a valid person-centered measure of manual ability in everyday activities. The stability of the item-difficulty hierarchy across different patient classes further supports the clinical application of the scale.
Matrix completion for SPOC student peer-grading evaluation

In this paper, we detail our efforts at designing a study to evaluate the quality of peer-grading for a SPOC course. Peer grading is an common used strategy to evaluate students learning performance in MOOC/SPOC courses. The strategy assign an author's work to his classmates who take the responsibility to be reviewers of the author's work. Both reviewer and reviewee are classmates who come from same course. Low quality peer grading is still a challenge due to the level of reviewers and the relationship between reviewer and reviewee. We propose a regression model to represent the correlation of student performance on subjective question and objective question. Then a measurement is presented to assess the quality of peer grading of subjective assignments. Addressing the high missing rate of score record of objective questions, three matrix completion algorithms are introduced in order to make the record complete. Experiments show that the validity of the proposed evaluation method. Instructors can leverage peer grading in their classes and to deal with homework evaluation more easily.
Mutant insulin receptors in syndromes of insulin resistance

Several distinct clinical syndromes are associated with marked resistance to the actions of insulin. In addition, insulin resistance plays a major role in the pathogenesis of non-insulin-dependent diabetes (De Fronzo, 1988) and is a central feature of a constellation of atherogenic metabolic alterations sometimes referred to as ‘Syndrome X’ (Reaven, 1988). The cloning of the human insulin receptor cDNA (Ullrich et al., 1985; Ebina et al., 1985) and more recently, the characterization of the receptor’s genomic organization (Seino et al., 1989) have allowed examination of t.he contribution of inherited defects in the receptor to the various syndromes of insulin resistance (Taylor S.I. et al., 1990; Taylor R., 1991). A decade or more of investigation in these various syndromes had led to the conclusion that a primary inherited defect of insulin action might be present. The finding of insulin receptor mutations in patients with these disorders has not only clarified the molecular basis of several clinical syndromes but has also complemented the intensive effort of basic scientists interested in the complex signalling functions of this molecule. Unlike site-directed mutants generated in vitro to test the structure/function relationships of various insulin receptor domains, naturally occurring mutations have provided unique ‘experiments of nature’ which are known in advance to have consequences for invivo metabolism.
The Mechanism of Platelet Aggregation Induced by HLA-Related Antibodies

Summary Immune-mediated platelet activation is emerging as an important pathogenic mechanism of thrombosis. In vitro studies have suggested two distinct pathways for immune-mediated platelet activation; one involving clustering of platelet FcyRIIa, the other involving platelet-associated complement activation. HLA-related antibodies have been shown to cause platelet aggregation, but the mechanism has not been clarified. We evaluated the mechanism of platelet aggregation induced by HLA-related antibodies from nine patients. Antibody to platelet FcyRIIa failed to block platelet aggregation with 8/9 samples, indicating that engagement of platelet FcyRIIa is not necessary for the platelet aggregation induced by HLA-related antibodies. In contrast, platelet aggregation was blocked by antibodies to human C8 (5/7) or C9 (7/7). F(ab’)2 fragments of patient IgG failed to induce platelet activation although they bound to HLA antigen on platelets. Intact patient IgG failed to aggregate washed platelets unless aged serum was added. The activating IgG could be adsorbed by incubation with lymphocytes and eluted from the lymphocytes. These results indicate that complement activation is involved in the aggregation response to HLA-related antibodies. This is the first demonstration of complement-mediated platelet aggregation by clinical samples. Five of the patients developed thrombocytopenia in relationship to blood transfusion and two patients developed acute thromboembolic disease, suggesting that these antibodies and the complement-dependent pathway of platelet aggregation may be of clinical significance.
Upper Bounds for Bermudan Style Derivatives

Based on a duality approach for Monte Carlo construction of upper bounds for American/Bermudan derivatives (Rogers, Haugh & Kogan), we present a new algorithm for computing dual upper bounds in a more efficient way. The method is applied to Bermudan swaptions in the context of a LIBOR market model, where the dual upper bound is constructed from the maximum of still alive swaptions. We give a numerical comparison with Andersen's lower bound method.
Perception of longitudinal body axis in patients with stroke: a pilot study

Background and aims: To investigate the hypothesis that patients with a hemisphere stroke may perceive their longitudinal body axis (LBA) rotated in the frontal plane. This error in an egocentric frame of reference could be detrimental to posture, as tilted LBA would imply an unequal distribution of body mass about the true vertical. Method: 26 healthy subjects matched in age with 18 patients living with stroke participated in the study. The 18 patients were tested on average 80 days after a first left (n = 8) or right (n = 10) hemisphere stroke. Participants perceived their LBA by adjustments of the orientation of a luminous rod pivoting around a dorsonavel axis to the subjective direction of LBA. Participants were studied in the supine position to dissociate somaesthetic cues from graviceptive cues. Results: Patients with stroke perceived their LBA rotated to the contralesional side in comparison with controls (p = 0.004). For all controls and 10 patients with stroke, the perceived LBA was very close to true LBA (mean (SD) 0.24° (1.31°)). For eight patients with stroke (six right stroke, two left stroke), the perceived LBA was rotated from true body orientation in the direction opposite to the lesioned side (range 3–9.5°, mean 5.2°). These eight patients provided similar estimates by tactile manipulation of the rod (without vision). The rotation of perceived LBA was more pronounced for right-hemisphere strokes. The magnitudes of perceptual rotations correlated with sensory loss, signs of spatial neglect and the degree of postural and gait disability. Conclusion: This is the first study showing that certain patients with a hemisphere stroke perceive their LBA rotated to the contralesional side. The consequences for perceptuomotor coordination have implications for their postural disorders.
Hybrid BIST using partially rotational scan

Developed a partially rotational scan (PRS) register used for the n-detection BIST (built-in self-test) that can detect not only delay faults but also unmodeled faults. The developed circuit consists of a shift register with partial rotation. Also presents a procedure for selecting test vectors from ATPG (automatic test pattern generation) ones. This testing method enables at-speed testing and the stuck-at fault coverage of n/spl times/100% by using subset of the ATPG vectors. And it drastically reduces the number of vectors input from an external low-speed tester. Computer simulations of stuck-at fault coverage are conducted on ISCAS'85, ISCAS'89, and ITC'99 circuits for detection times n of 1, 2, 3, 5, 10, and 15. They show that the compaction rates of the ATPG test vectors range from 52.4% (s713) to 0.9% (c499) of origin. This result demonstrates that the PRS register can accomplish low-cost, at-speed testing.
Um modelo para suporte ao raciocínio diagnóstico diante da dinâmica do conhecimento sobre incertezas

The Knowledge Engineering uses transdisciplinary ap proaches aiming to provide solutions to social demands, especially, ar tifacts for decision support. The human decision making can be so comple x that the magnitude knowledge intensive activity undertaken by speciali st demande assistance from models developed by a systemic view of the kno wledge engineer in the solution space. The problem of this research em erges from the activity of the specialist physician in Metabolic Risk Ratin g in children and adolescents. The variables of this scenario and the classification process is uncertain, expressed by causality and imprecision. Bayesian networks are employed to support the classification whose variab les representing knowledge are probabilistic in nature. However, the classical Bayesian method, given the uncertainty factor can converge t o results unskilled in accordance to those obtained by clinical reasoning. On the other hand, improved Bayesian Networks Fuzzy-classical model to support inference about ambiguous concepts. This research contributed to the development of a fuzzy-Bayesian inference for non-dichotomous vari ables supporting the medical reasoning in a complex scenario whose dynam ics of vagueness is characterized by a kind of conceptual overlay. Esse ntially offers mathematical formalism modifying the equation of Ba yes Theorem, introducing fuzzy qualifiers to deal with imprecisi on. To verify the model we used simulations applied to real data from medic al records. The results obtained were convergent with interpretation specia list nd notable feature was the quality of these results in the ranges near the cutoff points used by experts and reproduced by classical Bayesian method , a problem that does not excuse the inaccuracy. The distributed model th odds of diagnostic hypotheses tracking the dynamics inherent imprecisi on of the evidence. This effect shows that a patient, even if gradually , may be evolving into a scenario of metabolic risk. The model is likely to be coupled to the Knowledge Engineering methodologies and their imple entation can generate a tool coupled with the practice of clinic al diagnosis.
Is There a Decline in the Vascular Event Rate after Transient Ischemic Attack or Stroke in Antiplatelet Trials?

Background: We examined the baseline characteristics and the rates of serious vascular events in randomized clinical trials after cerebral ischemia of presumed arterial origin to identify study features that predict vascular event incidence and to identify whether event rates have declined over time. Methods: We performed a systematic review to identify all published randomized controlled trials of patients with stroke or transient ischemic attack of presumed arterial origin that included an aspirin arm. We performed metaregression to analyze whether baseline features of included patients, design features and the year of study start and publication influenced vascular event rates under aspirin treatment. Results: Included studies comprised 23,247 patients who had 3,615 serious vascular events. Baseline characteristics of patients included in the different trials varied substantially over time. In multivariate metaregression analysis a shorter maximum allowed delay from symptom onset to randomization (p = 0.012) and a double-blind design were associated with higher annual event rates (p = 0.014). Event rates did not significantly decrease over time (p = 0.242). Conclusion: The baseline characteristics of patients included in trials that study antiplatelet agents have changed over time. The strongest predictors for higher event rates are a double-blind design and a short delay between symptom onset and randomization. An important reduction in event rates over time could not be demonstrated.