Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of two superimposed laser beams on spatter formation during laser welding of high alloyed steel

This paper presents an experimental approach for the reduction of the spatter formation during deep penetration laser welding using the spatial superposition of two laser spots. Experimental testing was performed on high alloyed austenitic steel sheets using both a high power disk laser and a diode laser. The spatter formation was reduced significantly through this approach in comparison to a conventional process using a standard top hat power density. High-speed images show the differences in the weld pool behavior in terms of the capillary length and the fluctuation of the metal vapor caused by the additional laser spot.This paper presents an experimental approach for the reduction of the spatter formation during deep penetration laser welding using the spatial superposition of two laser spots. Experimental testing was performed on high alloyed austenitic steel sheets using both a high power disk laser and a diode laser. The spatter formation was reduced significantly through this approach in comparison to a conventional process using a standard top hat power density. High-speed images show the differences in the weld pool behavior in terms of the capillary length and the fluctuation of the metal vapor caused by the additional laser spot.
Acquisition of Phrase Correspondences Using Natural Deduction Proofs

How to identify, extract, and use phrasal knowledge is a crucial problem for the task of Recognizing Textual Entailment (RTE). To solve this problem, we propose a method for detecting paraphrases via natural deduction proofs of semantic relations between sentence pairs. Our solution relies on a graph reformulation of partial variable unifications and an algorithm that induces subgraph alignments between meaning representations. Experiments show that our method can automatically detect various paraphrases that are absent from existing paraphrase databases. In addition, the detection of paraphrases using proof information improves the accuracy of RTE tasks.
Optimized genotyping method for identification of bacterial contaminants in pharmaceutical industry

Abstract Microbiological control is of crucial importance in the pharmaceutical industry regarding the possible bacterial contamination of the environment, water, raw materials and finished products. Molecular identification of bacterial contaminants based on DNA sequencing of the hypervariable 16SrRNA gene has been introduced recently. The aim of this study is to investigate the suitability of gene sequencing using our selection of PCR primers and conditions for rapid and accurate bacterial identification in pharmaceutical industry quality control. DNA was extracted from overnight incubated colonies from 10 bacterial ATCC strains, which are common contaminants in the pharmaceutical industry. A region of bacterial 16SrRNA gene was analyzed by bidirectional DNA sequencing. Bacterial identification based on partial sequencing of the 16SrRNA gene is the appropriate method that could be used in the pharmaceutical industry after adequate validations. We have successfully identified all tested bacteria with more than 99 % similarity to the already published sequences.
Accurate WiFi Based Localization for Smartphones Using Peer Assistance

Highly accurate indoor localization of smartphones is critical to enable novel location based features for users and businesses. In this paper, we first conduct an empirical investigation of the suitability of WiFi localization for this purpose. We find that although reasonable accuracy can be achieved, significant errors (e.g., 6 8m) always exist. The root cause is the existence of distinct locations with similar signatures, which is a fundamental limit of pure WiFi-based methods. Inspired by high densities of smartphones in public spaces, we propose a peer assisted localization approach to eliminate such large errors. It obtains accurate acoustic ranging estimates among peer phones, then maps their locations jointly against WiFi signature map subjecting to ranging constraints. We devise techniques for fast acoustic ranging among multiple phones and build a prototype. Experiments show that it can reduce the maximum and 80-percentile errors to as small as 2m and 1m, in time no longer than the original WiFi scanning, with negligible impact on battery lifetime.
Cellular and Subcellular Localization of Phototropin 1 Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.003293.

Phototropin 1 (phot1) is a Ser/Thr photoreceptor kinase that binds two molecules of flavin mononucleotide as its chromophores and undergoes autophosphorylation in response to blue light. Phot1 is plasma membrane associated and, as with phot2, has been shown to function as a photoreceptor for phototropism, blue light–induced chloroplast movement, and blue light–induced stomatal opening. Phot1 likely also plays a redundant role with phot2 in regulating the rate of leaf expansion. Understanding the mechanism(s) by which phot1 initiates these four different responses requires, at minimum, knowledge of where the photoreceptor is located. Therefore, we transformed a phot1 null mutant of Arabidopsis with a construct encoding translationally fused phot1–green fluorescent protein (GFP) under the control of the endogenous PHOT1 promoter and investigated its cellular and subcellular distribution. This PHOT1-GFP construct complements the mutant phenotype, restoring second positive curvature. Phot1 is expressed strongly in dividing and elongating cortical cells in the apical hook and in the root elongation zone in etiolated seedlings. It is localized evenly to the plasma membrane region in epidermal cells but is confined largely to the plasma membrane region of the transverse cell walls in the cortical cells of both root and hypocotyl. It is found at both apical and basal ends of these cortical cells. In light-grown plants, phot1–GFP is localized largely in the plasma membrane regions adjacent to apical and basal cell end walls in the elongating inflorescence stem, where the photoreceptor is expressed strongly in the vascular parenchyma and leaf vein parenchyma. Phot1 also is localized to the plasma membrane region of leaf epidermal cells, mesophyll cells, and guard cells, where its distribution is uniform. Although phot1 is localized consistently to the plasma membrane region in etiolated seedlings, a fraction becomes released to the cytoplasm in response to blue light. Possible relationships between observed phot1 distribution and the various physiological responses activated by blue light are discussed.
Efficacy of a Student-Led, Community-Based, Multifactorial Fall Prevention Program: Stay in Balance

Background Falls are a major public health concern in older adults. Recent fall prevention guidelines recommend the use of multifactorial fall prevention programs (FPPs) that include exercise for community-dwelling older adults; however, the availability of sustainable, community-based FPPs is limited. Methods We conducted a 24-week quasi-experimental study to evaluate the efficacy of a community-based, multifactorial FPP [Stay in Balance (SIB)] on dynamic and functional balance and muscular strength. The SIB program was delivered by allied health students and included a health education program focused on fall risk factors and a progressive exercise program emphasizing lower-extremity strength and balance. All participants initially received the 12-week SIB program, and participants were non-randomly assigned at baseline to either continue the SIB exercise program at home or as a center-based program for an additional 12 weeks. Adults aged 60 and older (n = 69) who were at-risk of falling (fall history or 2+ fall risk factors) were recruited to participate. Mixed effects repeated measures using Statistical Application Software Proc Mixed were used to examine group, time, and group-by-time effects on dynamic balance (8-Foot Up and Go), functional balance (Berg Balance Scale), and muscular strength (30 s chair stands and 30 s arm curls). Non-normally distributed outcome variables were log-transformed. Results After adjusting for age, gender, and body mass index, 8-Foot Up and Go scores, improved significantly over time [F(2,173) = 8.92, p = 0.0; T0 − T2 diff = 1.2 (1.0)]. Berg Balance Scores [F(2,173) = 29.0, p < 0.0001; T0 − T2 diff = 4.96 (0.72)], chair stands [F(2,171) = 10.17, p < 0.0001; T0 − T2 diff = 3.1 (0.7)], and arm curls [F(2,171) = 12.7, p < 0.02; T0 − T2 diff = 2.7 (0.6)] also all improved significantly over time. There were no significant group-by-time effects observed for any of the outcomes. Conclusion The SIB program improved dynamic and functional balance and muscular strength in older adults at-risk for falling. Our findings indicate continuing home-based strength and balance exercises at home after completion of a center-based FPP program may be an effective and feasible way to maintain improvements in balance and strength parameters.
The automatic translation of idioms: machine translation vs. translation memory systems

Translating idioms is one of the most difficult tasks for human translators and translation machines alike. The main problems consist in recognizing an idiom and in distinguishing idiomatic from non-idiomatic usage. Recognition is difficult since many idioms can be modified and others can be discontinuously spread over a clause. But with the help of systematic idiom collections and special rules the recognition of an idiom candidate is always possible. The distinction between idiomatic and non-idiomatic usage is more problematic. Sometimes this can be done by means of special words that are only used in an idiom. But in general this distinction is a question of semantics and pragmatics and therefore beyond the abilities of current translation systems. In this paper we investigate the requirements for automatically recognizing idioms and we check whether idiom recognition is possible within current translation systems, i.e. machine translation and translation memory systems. This is of current interest since the developers of translation systems have started to include huge idiom collections in their products.
Ca2+-Activated Anion Channels and Membrane Depolarizations Induced by Blue Light and Cold in Arabidopsis Seedlings

The activation of an anion channel in the plasma membrane of Arabidopsis thaliana hypocotyls by blue light (BL) is believed to be a signal-transducing event leading to growth inhibition. Here we report that the open probability of this particular anion channel depends on cytoplasmic Ca2+ ([Ca2+]cyt) within the concentration range of 1 to 10 [mu]M, raising the possibility that BL activates the anion channel by increasing [Ca2+]cyt. Arabidopsis seedlings cytoplasmically expressing aequorin were generated to test this possibility. Aequorin luminescence did not increase during or after BL, providing evidence that Ca2+ does not play a second-messenger role in the activation of anion channels. However, cold shock simultaneously triggered a large increase in [Ca2+]cyt and a 110-mV transient depolarization of the plasma membrane. A blocker of the anion channel, 5-nitro-2-(3-phenylpropylamino)-benzoic acid, blocked 61% of the cold-induced depolarization without affecting the increase in [Ca2+]cyt. These data led us to propose that cold shock opens Ca2+ channels at the plasma membrane, allowing an inward, depolarizing Ca2+ current. The resulting large increase in [Ca2+]cyt activates the anion channel, which further depolarizes the membrane. Although an increase in [Ca2+]cyt may activate anion channels in response to cold, it appears that BL does so via a Ca2+-independent pathway.
Modulation of Chromatin Remodelling Induced by the Freshwater Cyanotoxin Cylindrospermopsin in Human Intestinal Caco-2 Cells

Cylindrospermopsin (CYN) is a cyanotoxin that has been recognised as an emerging potential public health risk. Although CYN toxicity has been demonstrated, the mechanisms involved have not been fully characterised. To identify some key pathways related to this toxicity, we studied the transcriptomic profile of human intestinal Caco-2 cells exposed to a sub-toxic concentration of CYN (1.6 µM for 24hrs) using a non-targeted approach. CYN was shown to modulate different biological functions which were related to growth arrest (with down-regulation of cdkn1a and uhrf1 genes), and DNA recombination and repair (with up-regulation of aptx and pms2 genes). Our main results reported an increased expression of some histone-modifying enzymes (histone acetyl and methyltransferases MYST1, KAT5 and EHMT2) involved in chromatin remodelling, which is essential for initiating transcription. We also detected greater levels of acetylated histone H2A (Lys5) and dimethylated histone H3 (Lys4), two products of these enzymes. In conclusion, CYN overexpressed proteins involved in DNA damage repair and transcription, including modifications of nucleosomal histones. Our results highlighted some new cell processes induced by CYN.
Effect of microalgae application on soil algal species diversity, cation exchange capacity and organic matter after herbicide treatments

Soil microalgae live on small communities that change structure depending on many factors. Some of these factors include soil pH, agricultural practices as well as pesticide and herbicide treatments. The size and activity of these soil microbial communities is an indicator of health, quality and fertility necessary for sustainable agriculture. Methods: A commercial proprietary suspension of microalgae GOgreen ® was applied at different concentrations through a center pivot irrigation system to a crop of cultivated corn ( Zea mays ) during six months. Experimental plots of 0.5 acres each were planted in four rows. Corn (34,000 plants/acre) was planted in May and harvested in November allowing each plot to be studied for 6 months. In addition, one plot was planted for a second year to study the effects of consecutive planting and harvesting on algae populations in the soil. Soil samples were collected at a depth of 6 inches. Microalgae species identification was based on morphological criteria. Soil analysis included organic matter content (OM), pH and cation exchange capacity (CEC). Results: Treatment with GOgreen ® has significant and measurable positive effects on soil OM content, CEC, pH and microalgae species diversity. Conclusions: It was demonstrated through this study that GOgreen ® increased diatom numbers and microalgae species diversity showing a restorative effect on soil quality after herbicide treatment in heavily farmed soil. Additionally, GOgreen ® lowers the pH in soils with a pH higher than 7.0 emerging as an economical alternative that is safe for humans and the environment.
A field experiment to assess the impact of information provision on household electricity consumption

We report on the results of two field experiments that we ran by partnering with two California electric utilities. In late 2011, 2,012 households participated in a customized on-line interactive educational program that taught them how their monthly electricity bill was determined from nonlinear retail pricing scheme they face. Each household was also shown their own location on this nonlinear pricing schedule. Participants were taught how changes in their major electricity-consuming activities would affect their monthly bill under the nonlinear pricing scheme. Using data from before and after this intervention for households that took the educational program (our treatment) and a randomly selected set of control households who did not take our treatment, we applied a standard average treatment effects estimation procedure to assess the impact of our information invention on a household’s monthly electricity consumption. For both utilities, we find that households that learn they face a high marginal price for consuming electricity reduce their electricity consumption relative to the control group. We also find that households that learn they face a low marginal price increase their electricity consumption relative to the control group. These results emphasize that the need to provide timely and actionable information to households in order to maximize the effectiveness of nonlinear retail pricing schemes.
Effects of spatial and nonspatial memory tasks on choice stepping reaction time in older people.

BACKGROUND Studies comparing the effects of spatial and nonspatial secondary tasks on balance have produced conflicting results. However, in most of these studies the difficulty levels of the secondary tasks have not been matched. In this study, we compared the effects of carefully matched visuospatial (VS) and nonspatial (NS) secondary tasks on choice stepping reaction time (CSRT). METHODS Forty-one older people (mean age 78.8 years) completed a CSRT test under five conditions: (i) no secondary task; (ii) an easy NS counting backward task; (iii) a difficult NS counting back task; (iv) an easy VS memory task; and (v) a difficult VS memory task. Response times and secondary task errors were measured for each condition. Participants also gave difficulty ratings for each secondary task. RESULTS The difficult tasks were rated significantly more difficult than the easy tasks in both VS and NS conditions, and cognitive task errors were moderately correlated with perceived difficulty. A repeated-measure analysis of variance with planned contrasts revealed a significant effect of task type, with the VS condition slowing CSRT more than the NS condition. There was also a significant task difficulty effect with the more difficult tasks increasing CSRT. CONCLUSIONS The findings suggest that VS cognitive tasks affect CSRT more so than do NS tasks. The visuospatial sketchpad appears to be specifically utilized for carrying out motor tasks necessary for preserving balance. Practical implications are that tasks that require visuospatial attention and memory may adversely influence balance control in older people.
Are changes in drinking related to changes in cannabis use among Swedish adolescents? A time–series analysis for the period 1989–2016

AIMS To examine if changes in alcohol consumption are associated with changes in cannabis use among Swedish adolescents in a period of diverging trends, and to investigate if cannabis and alcohol act as complements or substitutes. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS Data comprise a nationally representative annual school survey of alcohol and drug habits among Swedish 9th-grade students (aged 15-16 years) covering years 1989-2016 (n = 149 603). Alcohol and cannabis use were measured concurrently and alcohol consumption was measured in litres of 100% alcohol per year. Frequency of cannabis use was transformed into a mean using category mid-points. Autoregressive integrated moving average (ARIMA) time-series analysis was used to estimate the association between cannabis and alcohol use. To elucidate changes in the association during the study period, two subperiods (2000-16 and 1989-99) were analysed. FINDINGS There was a positive and statistically significant association between changes in alcohol consumption and changes in frequency of cannabis use among cannabis users for the period 1989-2016. A 1-litre increase in mean alcohol consumption was associated with a 0.28 increase in frequency of cannabis use (P = 0.010). The corresponding increase for the period 1989-99 was 0.52 (P = 0.003). When restricting the analysis to 2000-16, the association was not statistically significant (P = 0.735). When analysing all adolescents we found no statistically significant association between changes in alcohol consumption and changes in frequency of cannabis use. CONCLUSIONS From 1989 to 2016 there appears to be a positive association between alcohol and cannabis consumption among Swedish adolescents who use cannabis. This association seems to have become weaker over time, suggesting that alcohol and cannabis are neither substitutes nor complements among Swedish adolescents and that the recent decline in youth drinking is not associated with the increase in frequency of cannabis use.
Stimulation Efficiency With Decaying Exponential Waveforms in a Wirelessly Powered Switched-Capacitor Discharge Stimulation System

The purpose of this study was to test the feasibility of using a switched-capacitor discharge stimulation (SCDS) system for electrical stimulation, and, subsequently, determine the overall energy saved compared to a conventional stimulator. We have constructed a computational model by pairing an image-based volume conductor model of the cat head with cable models of corticospinal tract (CST) axons and quantified the theoretical stimulation efficiency of rectangular and decaying exponential waveforms, produced by conventional and SCDS systems, respectively. Subsequently, the model predictions were tested in vivo by activating axons in the posterior internal capsule and recording evoked electromyography (EMG) in the contralateral upper arm muscles. Compared to rectangular waveforms, decaying exponential waveforms with time constants >500 μs were predicted to require 2%–4% less stimulus energy to activate directly models of CST axons and 0.4%–2% less stimulus energy to evoke EMG activity in vivo. Using the calculated wireless input energy of the stimulation system and the measured stimulus energies required to evoke EMG activity, we predict that an SCDS implantable pulse generator (IPG) will require 40% less input energy than a conventional IPG to activate target neural elements. A wireless SCDS IPG that is more energy efficient than a conventional IPG will reduce the size of an implant, require that less wireless energy be transmitted through the skin, and extend the lifetime of the battery in the external power transmitter.
Sexual dimorphism, phenotypic integration, and the evolution of head structure in casque‐headed lizards

Sexes can differ in features associated with differential reproduction, which can be used during courtship or aggressive encounters. Some traits tend to evolve independently between sexes and emerge as sexually dimorphic within the organismal phenotype. We characterize such a relationship by estimating the phenotypic integration of the head morphology and modularity of the crest in the casque-headed lizards (Corytophanidae). In this clade, some species show extreme sexual dimorphism (e.g., head crests in the genus Basiliscus) while in others, both sexes are monomorphic. To characterize these patterns, we define phenotypic integration at the interspecific level as a pattern or network of traits evidenced by phylogenetically adjusted correlations that persist among species. At this level, modularity is an increased connectedness (e.g., higher correlation) among sections of these networks that persist in a lineage during the evolution of complex phenotypes. To test both concepts, we used phylogenetic geomorphometrics to characterize the head structure of corytophanid lizards, based on a time-calibrated phylogeny that includes candidate fossil ancestors. We found evidence of an older diversification of corytophanids than previously reported (~67 vs. ~23.5 MYA) and show that this clade includes two morphological head architectures: (1) Sexually dimorphic crests present in males that are evolving independently from the rest of the head structure, and (2) full integration of the head morphology in monomorphic species. We propose that both architectures are optimal evolutionary trajectories of the parietal crest bones in the head of these lizards. In sexually dimorphic species, these bones are elongated and thinner, and gave rise to the extended crest used in male courtship displays. In monomorphic species, the parietal crest grew thicker in both sexes to allow for a better insertion of muscles associated with a stronger bite.