Miracle-dz/UniFAR-FTUs huggingface dataset:
Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis*

A detailed kinetic analysis of three extranuclear end points of apoptosis, phosphatidylserine exposure, α-fodrin degradation, and plasma membrane blebbing, was performed and compared with nuclear fragmentation and the activation of the interleukin-1β-converting enzyme (ICE)-like proteases in Jurkat T lymphocytes stimulated by anti-Fas monoclonal antibody (anti-Fas mAb) and in monocytic U937 cells stimulated by tumor necrosis factor (TNF) and cycloheximide. Phosphatidylserine exposure was quantitated by plasma clotting time, as well as annexin V-fluorescein isothiocyanate binding, and the ICE-like protease activity was examined by the cleavage of a specific fluorogenic peptide substrate Ac-Asp-Glu-Val-Asp-amino-4-methylcoumarin. VAD-chloromethylketone (VAD-cmk), an inhibitor of ICE-like proteases, effectively inhibited ICE-like activity in both cell types studied, whereas the calpain inhibitor calpeptin was ineffective. VAD-cmk also effectively inhibited all three extranuclear events, as well as nuclear fragmentation, in Jurkat cells stimulated by anti-Fas monoclonal antibody, indicating that ICE-like proteases play an important role in the regulation of this apoptotic system. Calpain inhibitors were ineffective in this system. TNF-induced extranuclear and nuclear changes in U937 cells were inhibited by calpeptin but were not as effectively inhibited by VAD-cmk as in Jurkat cells. This suggests that ICE-like enzymes predominate in anti-Fas monoclonal antibody-stimulated Jurkat cells, whereas proteases affected by calpain inhibitors as well as the ICE-like enzymes are involved in the signaling of apoptotic events in TNF-induced U937 cells. Importantly, the two apoptotic systems seem to be regulated by different proteases.
Ricerca del saggio di capitalizzazione nel mercato immobiliare

In the search of capitalization rate, the international valuation standards impose the reference to the data and the information of real estate market of the same segment or, very probably, in similar segments of the property being appraised. In this last case with adjustments of rents and market prices. The adjustments don’t concern the capitalization rate but rents and prices. Accordingly capitalization rate cannot be obtained by the rate other than real estate investments, for instance financial, because a property market segment, where data can be collected, always exists.
Human Disposition Detection using EEG signal and Facial Expression : A Survey

Multimedia content is made to induce emotions and be emotionally expressive, the need and importance of automatic emotion recognition has grown with increasing role of human computer interface applications. Recent advances on affect detection are focused on detecting emotions continuously. In this paper, for the first time, we continuously detect valence from electroencephalogram (EEG) signals and facial expressions in response to human expression. Power spectral features from EEG signals as well as facial fiducial points are used as features to detect valence levels for each frame continuously. We study the correlation between features from EEG and facial expressions with continuous valence. We have also verified our model’s performance for the emotional highlight detection using emotion recognition from EEG signals. Finally the results of multimodal fusion between facial expression and EEG signals are presented. Having such models we will be able to detect spontaneous and subtle affective responses over time. So basically we trying to built an automatic emotion monitoring system. Due this we can easily treat physiological patient. This will best contribution for physiological field.
The Manipulation of Executive Stock Option Exercise Strategies: Information Timing and Backdating

I identify three option exercise strategies executives engage in, including (i) exercising with cash and immediately selling the shares, (ii) exercising with cash and holding the shares, and (iii) delivering some shares to the company to cover the exercise costs and holding the remaining shares. Stock price patterns suggest executives manipulate option exercises. They use private information to increase the profitability of all three strategies, and likely backdated some exercise dates in the pre-Sarbanes-Oxley period to enhance the profitability of the latter two strategies, where the executive’s company is the only counterparty. Backdating is associated with reporting of internal control weaknesses.
Tomada de decisão para ação social responsável no ensino de ciências

The main goal of the STS curriculum is to provide scientific and technological literacy for students so they can act as citizens and participate on decision making on the perspective of social responsibility. This paper discusses this educational goal and provides a review of the literature about its implications for science education. It also reflects on the National High School Curriculum related to the same objectives.
Uraemic symptoms, nutritional status and renal function in pre-dialysis end-stage renal failure patients.

BACKGROUND Deciding on the right moment to initiate dialysis and finding the best method to establish this critical stage of chronic renal failure are both controversial issues. This study attempted to address this subject by correlating a uraemic score with the most common clinical methods for assessing renal function in pre-dialysis chronic renal failure (end-stage renal disease, ESRD) patients. METHODS The study group consisted of 201 non-selected ESRD patients. A uraemic score, composed of the uraemic symptoms, the subjective global assessment of nutritional status, serum albumin concentration, and protein catabolic rate normalized for ideal body weight, was taken as a clinical marker of uraemic toxicity. Correlations that best fit this uraemic score with creatinine clearance (Ccr), the arithmetic mean of Ccr, urea clearance (Ccr-Cu) and Kt/V urea were then investigated. RESULTS Thirty-six per cent of patients had malnutrition. By multiple logistic regression analysis, the presence of comorbidity, Ccr-Cu and haematocrit were the best determinants of malnutrition. The correlation that best fit Ccr or Ccr-Cu with the uraemic score was a cubic curve (r=0.38, P<0.0001, and r=0.42, P<0.0001, respectively), in which an ascending inflection was observed when Ccr and Ccr-Cu fell below 12-13 and 10 ml/min, respectively. However, the relationship between Kt/V urea and the uraemic score was less predictable, especially in male patients. CONCLUSION Ccr or Ccr-Cu are reliable methods for establishing the degree of severity of chronic renal failure below which the development of symptoms and malnutrition are highly prevalent. In contrast, Kt/V urea may be a less sensitive and specific method for assessing the severity of uraemia in ESRD patients.
Pension Policy in Eu25 and its Possible Impact on Elderly Poverty

This paper reviews changes in pension policies in EU countries between 1995 and 2005 and describes how they might affect risk of poverty for future pensioner populations. The pension landscape in Europe has changed considerably in the past decade and the paper highlights commonalities as well as differences in pension reforms across these countries. A common trend is that the retirement incomes drawn from the public pension systems are on the decline, the changes are likely to shift more risks towards individuals, and there are fewer possibilities of redistribution in favour of the lower income individuals. The paper includes exploratory projections of how the risk of elderly poverty might evolve in the future. The countries where the benefit ratio is set to decline significantly, as expected, would see at-risk-poverty rates increase quite substantially, especially during the period 2025-2050, when the bulk of the decline is expected. This analysis points towards the importance of a more comprehensive assessment of the reforms, in particular in their impact on vulnerable groups (such as women and disabled people with disruptive work history) and in the clarity of the signals they give to individuals in extending their working career if they want to avoid greater risks of poverty during retirement.
Marital Dissolution and Work Disability A Longitudinal Study of Administrative Data

This study uses Norwegian administrative data in an analysis of sick leaves and receipt of health-related benefits over a period of five years surrounding marital dissolution. Expanding the literature on the poorer health of divorced compared with married individuals, it examines previously unexplored indicators of poor health and employs data collected at more frequent intervals than most prior studies. Results indicate that the selection of the less healthy into the divorced status is more important than health problems that result from marital dissolution itself; moreover, the latter effect is relatively short-lived. These results vary, however, by age, gender, and the presence of children, with stronger, negative effects of divorce found among parents and young men. Our findings are compared with the results from studies utilizing more conventional measures of health from survey data.
Visual Attention Region Prediction Based on Eye Tracking Using Fuzzy Inference

∗Department of System Design Engineering, Graduate School of Engineering, University of Fukui 3-9-1 Bunkyo, Fukui 910-8507, Japan E-mail: mwang@ir.his. u-fukui.ac.jp ∗∗Department of Robotics, Faculty of Engineering, Osaka Institute of Technology 5-16-1 Omiya, Asahi-ku, Osaka 535-8585, Japan E-mail: maeda@bme.oit. ac.jp ∗∗∗Department of Human and Artificial Intelligent Systems, Graduate School of Engineering, University of Fukui 3-9-1 Bunkyo, Fukui 910-8507, Japan E-mail: yasutake@ir.his. u-fukui.ac.jp
Approximating Gains from Trade in Two-sided Markets via Simple Mechanisms

We design simple mechanisms to approximate the Gains from Trade (GFT) in two-sided markets with multiple unit-supply sellers and multiple unit-demand buyers. A classical impossibility result by Myerson and Satterthwaite showed that even with only one seller and one buyer, no Bayesian Incentive Compatible (BIC), Individually Rational (IR), and Budget-Balanced (BB) mechanism can achieve full GFT (trade whenever buyer's value is higher than the seller's cost). The same paper also proposed the ``second-best'' mechanism that maximizes the GFT subject to BIC, IR, and BB constraints, which is unfortunately rather complex for even the single-seller single-buyer case. Our mechanism is simple, BIC, IR, and BB and achieves 1/2 of the optimal GFT among all BIC, IR, and BB mechanisms. The result holds for arbitrary distributions of the buyers' and sellers' values and can accommodate any downward-closed feasibility constraints over the allocations. The analysis of our mechanism is facilitated by extending the Cai-Weinberg-Devanur duality framework to two-sided markets.
Exercise intensity and load during mass-start stage races in professional road cycling.

PURPOSE To evaluate exercise intensity and load during mass-start stages in professional road cycling, using competition heart rate (HR) recordings. METHODS Seventeen world-class cyclists performed an incremental laboratory test during which maximal power output (Wmax), maximal HR (HRmax), onset of blood lactate accumulation (OBLA), lactate threshold (LT), and a HR-power output relationship were assessed. An OBLAZONE (HROBLA +/- 3 beats.min-1) and an LTZONE (HRLT +/- 3 beats.min-1) were described. HR was monitored during 125 flat (< 13 km uphill, < 800-m altitude change; FLAT), 99 semi-mountainous (13-35 km uphill, 800- to 2000-m altitude change; SEMO), and 86 high-mountain (> 35 km uphill, > 2000-m altitude change; HIMO) stages. Each cyclist's competition power output was estimated from competition HR and individual HR-power output relationships. Competition training impulse (TRIMP) values and time spent at "easy," "moderate," and "hard" zones were estimated from HR and race duration. RESULTS Average %HRmax were 61 +/- 5%, 58 +/- 6%, and 51 +/- 7% in HIMO, SEMO, and FLAT stages, respectively, and estimated average power outputs were 246 +/- 44, 234 +/- 43, and 192 +/- 45 W. Competition HR values relative to HROBLA and HRLT were, respectively, 69 +/- 6, 79 +/- 9% in HIMO; 65 +/- 7, 74 +/- 11% in SEMO; and 57 +/- 8, 65 +/- 10% in FLAT stages. The amount of TRIMP in HIMO, SEMO, and FLAT stages were, respectively, 215 +/- 38, 172 +/- 31, and 156 +/- 31. Percentage time spent in the "moderate" and "hard" zones was highest in HIMO (22 +/- 14, 5 +/- 6%) followed by SEMO (15 +/- 13, 5 +/- 5%) and FLAT (9 +/- 7, 2 +/- 2%) stages. CONCLUSIONS %HRmax, time distribution around HROBLA and HRLT, TRIMP, and load zones reflected the physiological demands of different mass-start cycling stage categories. The knowledge of these demands could be useful for planning precompetition training strategies.
Political Skill, Supervisor–Subordinate Guanxi and Career Prospects in Chinese Firms

The role of political skill was examined in the dynamics of supervisor–subordinate relationship in Chinese firms. Data from a survey of 343 employees, their 343 direct supervisors, and 662 of their peers were applied to test a model proposing that Chinese subordinates employ political skill to influence their guanxi with their supervisors, and so promote their career development. We found that supervisor–subordinate guanxi mediated the relationship between political skill and career development of the subordinates. Implications of the findings were discussed.
Robust Transfer Learning for Cross-domain Collaborative Filtering Using Multiple Rating Patterns Approximation

Collaborative filtering techniques are a common approach for building recommendations, and have been widely applied in real recommender systems. However, collaborative filtering usually suffers from limited performance due to the sparsity of user-item interaction. To address this issue, auxiliary information is usually used to improve the performance. Transfer learning provides the key idea of using knowledge from auxiliary domains. An assumption of transfer learning in collaborative filtering is that the source domain is a full rating matrix, which may not hold in many real-world applications. In this paper, we investigate how to leverage rating patterns from multiple incomplete source domains to improve the quality of recommender systems. First, by exploiting the transferred learning, we compress the knowledge from the source domain into a cluster-level rating matrix. The rating patterns in the low-level matrix can be transferred to the target domain. Specifically, we design a knowledge extraction method to enrich rating patterns by relaxing the full rating restriction on the source domain. Finally, we propose a robust multiple-rating-pattern transfer learning model for cross-domain collaborative filtering, which is called MINDTL, to accurately predict missing values in the target domain. Extensive experiments on real-world datasets demonstrate that our proposed approach is effective and outperforms several alternative methods.
Futures Trading, Market Interrelationships, and Industry Structure

Futures markets arise as a response to economic uncertainty. One goal of this paper is to measure how futures trading in existing contracts changes in response to changes in uncertainty caused by inflation. A difficult issue that other researchers have addressed is why only a small handful of all markets have successful futures markets (see, e.g., Telser and Higginbotham). Although we do not provide a complete answer to this question, we make progress toward an answer by investigating the covariance structure of various futures prices. This allows us to predict which markets are the least needed and to see whether
Managing Information Resources in State Government

The 1980s were the decade of major management change for information resources-getting timely and accurate information in the right form through the effective use of information services and information-handling technologies such as computers and telecommunications. This article reports on research completed by Syracuse University in 1989 on how executive branch officials in state governments in the 1980s significantly changed their information technology and information management approaches, otherwise known as information resources management (IRM). 1
Adapting information extraction knowledge for unseen Web sites

We propose a wrapper adaptation framework which aims at adapting a learned wrapper to an unseen Web site. It significantly reduces human effort in constructing wrappers. Our framework makes use of extraction rules previously discovered from a particular site to seek potential training example candidates for an unseen site. Rule generalization and text categorization are employed for finding suitable example candidates. Another feature of our approach is that it makes use of the previously discovered lexicon to classify good training examples automatically for the new site. We conducted extensive experiments to evaluate the quality of the extraction performance and the adaptability of our approach.
The impacts of country risk and cultural distance on transnational equity investments

Purpose – The purpose of this paper is to clarify the influence of country risk (CR) and cultural distance (CD) on transnational equity investments. It also tries to find out the international equity investment patterns of enterprises from developing countries like China.Design/methodology/approach – From the perspectives of internalization theory, transaction cost theory, etc. this paper tries to explain the relationships between country‐level factors and transnational investment. Based on the data collected from overseas listed companies, it also empirically analyses the impacts of CR and CD on Chinese enterprises' ownership pattern in transnational equity investment.Findings – The empirical results of this paper indicate that both the risk of host country and CD between host country and home country have significant and negative impacts on the level of ownership equity, but insignificant impacts on ownership status.Research limitations/implications – As there are still some doubts about the existence o.
Perceptions of Psychology as a Science among University Students: The Influence of Psychology Courses and Major of Study

The goal was to examine the relationship between the number of psychology courses students have taken and their perceptions of psychology as a science. Additionally, differences in perceptions of psychology among psychology, education, and natural science majors were examined. Results indicated that students who had taken four or more psychology courses had more favorable perceptions of psychology as a science compared to those who had taken no courses or one course and those who had taken two to three courses. No significant differences in overall perceptions of psychology emerged among students in the three majors.
How the Resource‐based and the Dynamic Capability Views of the Firm Inform Corporate‐level Strategy

Summary This paper explains that the resource-based view essentially addresses issues of competitive strategy, but by integrating some arguments from its evolutionary version, the dynamic capability view, it can be extended to inform our understanding of corporate-level strategy. We concentrate on the issue of value creation from corporate centres and ask how the centre can possess or provide resources. The primary dynamic capabilities identified by Teece, Pisano and Shuen (1997) are elaborated into six distinct modes of resource creation. Each mode is considered in relation to a set of organizational design parameters. We then propose resource-creating configurations that are congruent with respect to the modes and the required states of the design parameters. We point out areas of tension that are likely to arise if corporations try to combine different modes of resource creation. We conclude that corporate centres may possess resources but must display dynamic capabilities otherwise they will destroy shareholder value.
Accounting, Environmental Resource Values, and Non‐market Valuation Techniques for Environmental Resources: A Review

The primary focus concerns the measurement of non‐market environmental effects. It is suggested that the formal decision analysis advocated in traditional management accounting typically excludes a wide range of nonfinancial activities and that developments in environmental economics may prove useful in the development of more explicit procedures for corporate decision making. Different approaches to environmental resource decision making are discussed, along with different notions of environmental value, including use, option and preservation values. Finally, the different methods suggested by economists to obtain monetary values for non‐market resources, specifically the dose‐response, hedonic price, travel cost, and contingent valuation methods, are reviewed, with mention of some implications for private decision makers and accountants.
The Effects of Human Interest and Conflict News Frames on the Dynamics of Political Knowledge Gains: Evidence from a Cross‐national Study

A well-functioning democracy needs the news media to provide information to its citizens. It is therefore essential to understand what kinds of news contents contribute to gains in citizens' political knowledge and for whom this takes place. Extant research is divergent on this matter, especially with respect to ‘softer’ news coverage. This cross-national study investigates the effects of exposure to human interest and conflict frames in the news on political knowledge. Drawing on panel surveys and media content analyses in three countries, the study shows how these two frames contribute positively to political knowledge gain. This relationship is moderated by political interest so that those who are least interested learn the most from this type of easily accessible news coverage. The results are discussed in the light of research on news media and knowledge acquisition.
An exoskeletal robot for human elbow motion support-sensor fusion, adaptation, and control

In order to help everyday life of physically weak people, we are developing exoskeletal robots for human (especially for physically weak people) motion support. In this paper, we propose a one degree-of-freedom (1 DOF) exoskeletal robot and its control system to support the human elbow motion. The proposed controller controls the angular position and impedance of the exoskeletal robot system based on biological signals that reflect the human subject's intention. The skin surface electromyogram (EMG) signals and the generated wrist force by the human subject during the elbow motion have been fused and used as input information of the controller. In order to make the robot flexible enough to deal with vague biological signal such as EMG, fuzzy neuro control has been applied to the controller. The experimental results show the effectiveness of the proposed exoskeletal robot system.