Miracle-dz/UniFAR-FTUs huggingface dataset:
Update on Minimal Standards for Electroencephalography in Canada: A Review by the Canadian Society of Clinical Neurophysiologists

Abstract Surface electroencephalogram (EEG) recording remains the gold standard for noninvasive assessment of electrical brain activity. It is the most efficient way to diagnose and classify epilepsy syndromes as well as define the localization of the epileptogenic zone. The EEG is useful for management decisions and for establishing prognosis in some types of epilepsy. Electroencephalography is an evolving field in which new methods are being introduced. The Canadian Society of Clinical Neurophysiologists convened an expert panel to develop new national minimal guidelines. A comprehensive evidence review was conducted. This document is organized into 10 sections, including indications, recommendations for trained personnel, EEG yield, paediatric and neonatal EEGs, laboratory minimal standards, requisitions, reports, storage, safety measures, and quality assurance. RÉSUMÉ Mise à jour des normes minimales relatives à l’encéphalographie au Canada. L’utilisation d’un électroencéphalogramme (EEG) reste la méthode de référence pour évaluer de façon non invasive l’activité électrique cérébrale. Il s’agit du moyen le plus efficace pour diagnostiquer et catégoriser les syndromes épileptiques mais aussi pour définir l’emplacement des foyers épileptogènes. L’EEG est ainsi utile lorsqu’il s’agit de décider d’un traitement à donner et d’établir un pronostic dans le cas de certains types d’épilepsie. L’électroencéphalographie est aussi un domaine en évolution dans lequel de nouvelles méthodes sont introduites. La Société canadienne de neurophysiologie clinique a du coup constitué un comité d’experts afin d’élaborer, à l’échelle nationale, de nouvelles normes minimales. Pour ce faire, un examen exhaustif fondé sur des données probantes a été mené. Le document qui en a résulté est divisé en 10 sections : directives et recommandations destinées à du personnel qualifié, efficacité des EEG, EEG pédiatriques et néonatales, normes minimales en laboratoire, demandes d’EEG, production de rapports, conservation, mesures de sécurité et assurance de la qualité.
Experiments with the Negotiated Boolean Queries of the TREC 2009 Legal Track

Abstract : For our participation in the Batch Task of the TREC 2009 Legal Track, we produced several retrieval sets to compare experimental Boolean, vector, fusion and relevance feedback techniques for e-Discovery requests. In this paper, we have reported not just the mean scores of the experimental approaches but also the largest per-topic impacts of the techniques for several measures. The experimental automatic relevance feedback technique was found to attain a statistically significant gain over the reference Boolean result in both the mean Precision@B and F1@K measures.
Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins

Membrane microdomains or “lipid rafts” have emerged as essential functional modules of the cell, critical for the regulation of growth factor receptor-mediated responses. Herein we describe the dichotomy between caveolin-1 and caveolin-2, structural and regulatory components of microdomains, in modulating proliferation and differentiation. Caveolin-2 potentiates while caveolin-1 inhibits nerve growth factor (NGF) signaling and subsequent cell differentiation. Caveolin-2 does not appear to impair NGF receptor trafficking but elicits prolonged and stronger activation of MAPK (mitogen-activated protein kinase), Rsk2 (ribosomal protein S6 kinase 2), and CREB (cAMP response element binding protein). In contrast, caveolin-1 does not alter initiation of the NGF signaling pathway activation; rather, it acts, at least in part, by sequestering the cognate receptors, TrkA and p75NTR, at the plasma membrane, together with the phosphorylated form of the downstream effector Rsk2, which ultimately prevents CREB phosphorylation. The non-phosphorylatable caveolin-1 serine 80 mutant (S80V), no longer inhibits TrkA trafficking or subsequent CREB phosphorylation. MC192, a monoclonal antibody towards p75NTR that does not block NGF binding, prevents exit of both NGF receptors (TrkA and p75NTR) from lipid rafts. The results presented herein underline the role of caveolin and receptor signaling complex interplay in the context of neuronal development and tumorigenesis.
A 190-$\mu\hbox{W}$  zero-IF GFSK Demodulator With a 4-b Phase-Domain ADC

This paper presents a zero-IF Gaussian frequency-shift keying (GFSK) demodulator based on a phase-domain analog-to-digital converter (Ph-ADC) which directly quantizes the phase information of the received complex baseband signal. The Ph-ADC linearly combines the in-phase and quadrature parts of the incoming signal, and the generated phase-shifted versions are fed to comparators to detect the zero-crossings and build a 4-b digital representation of the signal phase. Seeking for a low-area and low-power consumption realization, our proposal employs a resistor-less scheme which performs phase rotations in current domain. Together with the Ph-ADC, the fully integrated GFSK demodulator also includes a channel-filtering programmable gain amplifier and a symbol decision block. Altogether, the demodulator occupies 0.14 mm2 in a 0.13- μm CMOS technology with a total power consumption of 190 μW from a 1-V supply. For a data rate of 1 Mbps and 0.5 modulation depth, the GFSK demodulator requires an EB/N0 of 14.8 dB for a bit error rate of 0.1% considering a flicker noise corner of 150 kHz, obtains a dynamic range of 74 dB, and is able to tolerate carrier frequency offsets of ±170 kHz. This performance safely complies with the requirements of the Bluetooth Low Energy (BLE) standard.
The treatment of subglottic stenosis in children by prolonged dilatation

Laryngeal stenosis can present with recurrent lower respiratory tract infections, hoarseness, stridor or decreased exercise tolerance. Asphyxia and death may follow. One accepted method of treatment is to perform a tracheostomy, dilate the stricture and insert an obturator for 6 to 9 mo.
The Modeling and Simulation Analysis on Four Corners Leveling System in Composite Material Hydraulic Press Based on AMESim / ADAMS

Four corners leveling system is one of the key parts of composite material hydraulic press, whose performances determine the pros and cons of the pressing performances. Electro-hydraulic control system is the most critical aspect in affecting the control characteristics. The kinematics and dynamics models of four corners leveling system based on ADAMS were established, while electro-hydraulic control system model based on AMESim was built. The above-mentioned simulation models formed the united simulation models for four corners leveling system. The effects of key parameters on control characteristics, including the dead zone and hysteresis of proportional valve and the hydraulic cylinder leakage, were analyzed by simulation, and the influence laws of various parameters on the synchronization control precision were obtained. Simulation results show that the single cylinder, double-cylinder or multi-cylinder existing dead zone and hysteresis and leakage can affect the synchronization error. Comparing with the working condition of single cylinder, the multicylinder with dead zone, hysteresis and leakage can significantly cause larger synchronization error. Key-Words: composite material hydraulic press; leveling system; synchronization; AMESim; ADAMS; cosimulation
Influence of HLA‐DR2 on perforin‐positive cells in pulmonary tuberculosis

Perforin is one of the key effector molecules of cytotoxic T cells and natural killer cells. The influence of HLA‐DRB1 alleles on peripheral blood perforin‐positive CD4, CD8, CD16 and CD56 cells was studied by flow cytometry. HLA‐DRB1 typing was done in normal healthy subjects (NHS: n = 156) and patients with pulmonary tuberculosis (PTB: n = 102) by polymerase chain reaction‐based sequence‐specific oligonucleotide hybridization method. We observed a significantly decreased percentage of total perforin‐positive cells (per+) (P = 0.0004); CD8+/Per+ (P = 0.0005); CD16+/Per+ (P = 0.05) and CD56+/Per+ cells (P = 0.001) in HLA‐DR2‐positive PTB patients compared to non‐DR2 patients. Subtyping of HLA‐DR2‐positive subjects at the allelic level revealed that the percentage of CD8+/Per+ cells did not differ among DRB1*1501 and DRB1*1502 patients while a trend towards a decreased percentage of CD16+/Per+ and CD56+/Per+ cells was noticed in DRB1*1501 patients compared to DRB1*1502 patients. The present study suggests that HLA‐DR2 may be associated with down‐regulation of perforin‐positive cytotoxic lymphocytes and natural killer cells in pulmonary tuberculosis.
A Human Milk Factor Susceptible to Cathepsin D Inhibitors Enhances Human Immunodeficiency Virus Type 1 Infectivity and Allows Virus Entry into a Mammary Epithelial Cell Line

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) growth in lymphocyte cultures was increased when the virus inoculum was incubated in breast milk. The enhancing effect of milk was abolished by anti-cathepsin D antibody or by pepstatin A, a cathepsin D inhibitor. The cathepsin D-producing CD4-negative MCF7 mammary cells supported the growth of some HIV-1 isolates. An MCF7 line chronically producing HIV-1 IIIb was obtained. Cathepsin D may induce conformational modification of viral gp120, allowing direct interaction with a coreceptor. We demonstrated the presence of CXCR4 mRNA in MCF7 cells.
Position Mutated Hierarchical Particle Swarm Optimization and its Application in Synthesis of Unequally Spaced Antenna Arrays

A family of position mutated hierarchical particle swarm optimization algorithms with time varying acceleration coefficients (viz. PM_nHPSO-TVAC, n = 1, 2, 3, 4) is introduced in this paper. The proposed position mutation schemes help the swarm to get out of local optima traps and the hierarchical nature of the swarm prevents premature convergence. One distinct advantage of the proposed algorithms over the existing mutated PSO algorithms is that PM_nHPSO-TVAC do not involve any controlling parameter. Performance of the proposed algorithms is evaluated on standard benchmark functions. Comparative study shows that PM_4HPSO-TVAC performs better than the other PM_n HPSO-TVAC, HPSO-TVAC, comprehensive learning PSO (CLPSO), adaptive-CLPSO (A-CLSPO), PSO with time-varying inertia weight (PSO-TVIW), and constriction factor PSO (CFPSO) for the benchmark functions considered. We apply the proposed algorithm to the synthesis of uniformly excited, unequally dpaced linear array to minimize sidelobe level (SLL) and to control first-null-beamwidth (FNBW) and null locations. Further, we apply the proposed algorithm to the synthesis of unequally spaced sparse planar array to minimize SLL.
Spectrum sharing in hybrid terrestrial-satellite backhaul networks in the Ka band

This work evaluates interference mitigation mechanisms to enable the operation of self-organizing hybrid terrestrial-satellite networks with aggressive frequency reuse between terrestrial and also satellite links. The objective is to take advantage of the improved capacity and resilience to congestion of such networks while assuring and efficient use of the spectrum. In particular, single- and multi-user hybrid analog-digital beamforming (HADB) techniques are considered as well as hybrid carrier allocation. The simulation results show network spectral efficiency improvements, with respect to conventional terrestrial backhaul systems, up to 2× when applying carrier allocation, and between 3.5× to 9× applying HADB in different environments.
Feasibility, Safety, and Periprocedural Complications of Pipeline Embolization for Intracranial Aneurysm Treatment Under Conscious Sedation: University at Buffalo Neurosurgery Experience

BACKGROUND: Endovascular Pipeline Embolization Device (PED) placement for intracranial aneurysms is performed under general anesthesia at most centers because of perceived improved image quality and patient safety. OBJECTIVE: To report the feasibility, safety, and outcomes associated with the use of the PED for intracranial aneurysms performed in awake patients after the administration of conscious sedation (CS) and a local anesthetic. METHODS: Between March 2012 and September 2014, 130 patients with 139 intracranial aneurysms (8 ruptured) were treated with the PED under CS at our institution. Procedure details and time (including duration, radiation exposure, and fluoroscopy) and procedure-related complications were retrospectively reviewed. RESULTS: A total of 155 PED deployment procedures were performed under CS. Treatment was successfully completed in all cases. Anesthesia was converted from CS to general anesthesia during 5 procedures. Mean interval from patient entry at the endovascular suite to procedure initiation was 18 minutes (range, 5 minutes-1 hour 10 minutes). Mean procedure length was 1 hour 25 minutes (range, 30 minutes-3 hours 51 minutes). Mean ± SD values for fluoroscopy time and radiation exposure were 36.17 ± 18.4 minutes and 1367 ± 897 mGy, respectively. The mean amount of contrast material administered was 211.37 ± 83.5 mL. Permanent neurological complications were seen in 4 patients (3%). CONCLUSION: In our experience, CS for PED placement for intracranial aneurysm treatment is feasible and safe. Procedure and fluoroscopy times and amount of radiation exposure are similar to or less than described in reports of PED placement under general anesthesia. CS allows direct neurological evaluation and earlier detection of and response to intraprocedural complications. ABBREVIATIONS: CS, conscious sedation GA, general anesthesia ICA, internal carotid artery PED, Pipeline Embolization Device
MEWSE: multi-engine workflow submission and execution on apache YARN

In this era of Big Data, organizations are attempting to gain new insights from the data by performing more complex analyses often involving multiple data sets and multiple analytic techniques. Creating a workflow to perform theses analyses can involve several analytic engines and require multiple transformations of the data as it flows through the steps of the task. Coordinating the jobs involved in a workflow is handled by a workflow management system. Current workflow systems, however, typically run only on one engine and do not offer the versatility required by analytic workflows. On the other hand, the process of submitting the jobs on different engines manually can be time consuming and requires the expertise of working with the various analytic engines. In this paper we present MEWSE - Multi Engine Workflow Submission and Execution on Apache YARN. Users submit multi-engine analytic workflows specified using an XML-based description language and MEWSE manages the scheduling and execution of the workflow on top of a YARN cluster. MEWSE is designed with plug and play functionalities to allow the inclusion of new engines as required. MEWSE is demonstrated on Amazon EC2 with a sample workflow that includes a combination of Hadoop, Mahout, Java programs and scripts to process the data.
Glucocorticoid regulation of cell survival in normal and cytokine-treated gastric chief cells

Gastric chief cells secrete pepsinogen and are found at the base of gastric glands. Chief cells constitutively express the anti-apoptotic protein Bcl-xL, which may enable them to live longer than other gastric cells. We reveal that the cytokines released as part of the inflammatory response during Helicobacter pylori infection dose-dependently disrupt chief cell monolayer integrity and viability. We also show that glucocorticoids dose-dependently increase expression of Bcl-xL, and hypothesize that this accounts for the ability of glucocorticoids to protect chief cells from cytokine-induced cell death. In addition, we show that glucocorticoids restrict the ability of cytokines to damage chief cell monolayer integrity. Finally, we propose two mechanisms by which cytokines overwhelm the protective ability of glucocorticoids, resulting in chief cell deletion and gastric atrophy during Helicobacter pylori infection.
A data-driven fault diagnosis approach towards oil retention in vapour compression refrigeration systems

In vapour compression refrigeration systems, oil circulates to lubricate moving parts. However, due to its low miscibility with most environmentally friendly refrigerants, such as ammonia, it is retained in some parts of the system causing losses in the overall system efficiency. Therefore, this paper focusses on the investigation of the fault characteristics of oil-retention by simulating this fault using a test facility. Based on the obtained dataset, a data-driven fault diagnosis approach is derived. Furthermore, a genetic algorithm is used for the selection of characteristic features, which are finally defined as input parameters for an exemplary implemented classification algorithm. It is also demonstrated how this classification algorithm correctly distinguishes multiple system states from one another.
First Results From an Experimental ScanSAR-GMTI Mode on RADARSAT-2

This paper demonstrates for the first time successful GMTI from a space-based SAR employing two parallel receive channels in the flight direction that operates in a scanSAR mode. ScanSAR in conjuction with GMTI offers wide-area monitoring of moving objects, an important prerequisite for many applications, for instance, maritime domain awareness. The multichannel capability to suppress background clutter permits improved detectability in challenging environments, such as vessel detection in near range or high sea states, and additionally offers the possibility to estimate target speeds and headings.
Therapy-related Myelodysplastic Syndrome with Monosomy 5 and 7 Following Successful Therapy for Acute Promyelocytic Leukemia with Anthracyclines

Myelodysplastic syndrome (MDS) in patients treated for acute promyelocytic leukemia (APL) is a rare event. We describe a patient with APL who developed MDS 40 months after entering complete remission (CR). Karyotypic analysis revealed monosomy 5 and 7, which are cytogenetic changes usually occurring after the use of alkylating agents. The patient had received only anthracyclines as potential leukemogenic drugs. A review of the literature on t-AML/MDS occurring after successful therapy for APL showed three similar cases. These observations suggest that anthracyclines may cause t-AML/MDS similar to that induced by alkylating agents.
Reason-based explanations and analytical sociology

The paper discusses Raymond Boudon’s theory of ordinary rationality as well as his assessment of so-called “analytical sociology. ” On the first point, the paper argues that, in order to combine the realism of an unconstrained conception of rationality with the ex-ante facto predictive power of the narrow version of rational choice theory, we should better understand the relation between potentially triggering events and the actor’s “reasons. ” Heuristics, social identity, and emotions may help build a broader rational choice theory. On the second point, the paper recalls some factual elements suggesting that Boudon’s assessment of analytical sociology is excessively severe and explains why some analytical sociologists are right in devoting special attention to computational modeling.
Turkish graveyards as refuges for orchids against tuber harvest

Abstract Harvest of orchid tubers for salep production is widespread in southwestern Asia and the Balkans and constitutes a major conservation risk for wild orchid populations. Synanthropic habitats, such as graveyards, are important refuges for orchids and other organisms and could offer protection from salep harvesting because of their special cultural role. However, little is known about the occurrence and factors influencing harvesting of salep in graveyards. During field surveys of 474 graveyards throughout Turkey, we observed 333 graveyards with orchids, 311 graveyards with tuberous orchids, and salep harvest in 14 graveyards. Altogether, 530 individuals of 17 orchid species were collected, representing 9% of the individuals recorded. Harvesting intensity was relatively low, and populations were usually not wholly destroyed. However, some species were clearly more affected than others. Salep harvesting risk of orchid species was significantly associated with flowering time, with early‐flowering species being more affected. A marginally significant positive relationship between harvesting risk and species‐specific tuber size was also detected. Our data suggest that graveyards might offer some protection against salep harvesting in Turkey, but they also show that some orchid taxa are much more affected than others. Overall, our observations add more weight to the conservation value of these special habitats.
Using Machine Learning to Estimate the Optimal Transmission Range for RPL Networks

Nowadays, IoT low power networks have been largely adopted in various scenarios such as the factory of the future, smart agriculture, smart cities, and so forth. These networks allow the interconnection of resource-constrained devices (e.g. actuators and sensors) using wireless communication links. In such networks, having energy-efficient routing protocols is necessary in order to maximize the network lifetime. However, many factors may influence the energy consumption in IoT low power networks. These factors include the transmission power of devices, the data routing strategy, etc. In this paper, we address the effect of the transmission power on energy consumption in RPL networks (RPL : IPV6 Routing Protocol for Low-Power and Lossy Networks) and propose a new solution based on a multi-layer perceptron (MLP) model, to estimate the optimal transmission range of dynamic IoT low power networks deployed following a 3D topology. The results of our experiments show that our MLP model perfoms well compared to other machine learning models.
Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down‐regulation of NADPH oxidase

Habitual aerobic exercise is associated with enhanced endothelium‐dependent dilatation (EDD) in older humans, possibly by increasing nitric oxide bioavailability and reducing oxidative stress. However, the mechanisms involved are incompletely understood. EDD was measured in young (6–8 months) and old (29–32 months) cage control and voluntary wheel running (VR) B6D2F1 mice. Age‐related reductions in maximal carotid artery EDD to acetylcholine (74 vs. 96%, P < 0.01) and the nitric oxide (NO) component of EDD (maximum dilatation with ACh and l‐NAME minus that with ACh alone was −28%vs.−55%, P < 0.01) were restored in old VR (EDD: 96%, NO: −46%). Nitrotyrosine, a marker of oxidative stress, was increased in aorta with age, but was markedly lower in old VR (P < 0.05). Aortic superoxide dismutase (SOD) activity was greater (P < 0.01), whereas NADPH oxidase protein expression (P < 0.01) and activity (P= 0.05) were lower in old VR vs. old cage control. Increasing SOD (with 4‐hydroxy‐2,2,6,6‐tetramethylpiperidine 1‐oxyl) and inhibition of NADPH oxidase (with apocynin) improved EDD and its NO component in old cage control, but not old VR mice. VR increased endothelial NO synthase (eNOS) protein expression (P < 0.05) and activation (Ser1177 phosphorylation) (P < 0.05) in old mice. VR did not affect EDD in young mice. Our results show that voluntary aerobic exercise restores the age‐associated loss of EDD by suppression of oxidative stress via stimulation of SOD antioxidant activity and inhibition of NADPH oxidase superoxide production. Increased eNOS protein and activation also may contribute to exercise‐mediated preservation of NO bioavailability and EDD with ageing.