Miracle-dz/UniFAR-FTUs huggingface dataset:
Connectivity-Preserving Synchronization of Time-Delay Euler–Lagrange Networks With Bounded Actuation

This paper proposes a strategy to overcome the threats posed to connectivity-preserving synchronization of Euler–Lagrange networks by time-varying delays and bounded actuation. It first introduces a suitable distributed negative gradient plus damping injection controller, based on which it establishes that the local connectivity of time-delay Euler–Lagrange networks can be preserved by appropriately regulating the interagent connections and increasing the damping injection locally. Yet, actuator saturation may impede the proper modulation of the interagent connections and the injection of sufficient damping and, thus, may threaten the maintenance of connectivity. This paper then develops an indirect coupling control framework which integrates the bounded actuation constraints into the control design. The framework endows every agent with a virtual proxy and couples initially adjacent agents through their virtual proxies. The interproxy couplings then tackle the time-varying delays while the agent-proxy couplings account for the saturation of actuators. Lyapunov–Krasovskii analysis proves that the indirect coupling strategy can drive time-delay Euler–Lagrange networks with bounded actuation to connectivity-preserving synchronization by limiting the energy of the agent-proxy and interproxy couplings according to the actuation constraints. Experiments with Geomagic Touch haptic robots validate the proposed designs compared to a conventional proportional plus damping controller.
A mm-Sized Free-Floating Wirelessly Powered Implantable Optical Stimulation Device

This paper presents a mm-sized, free-floating, wirelessly powered, implantable optical stimulation (FF-WIOS) device for untethered optogenetic neuromodulation. A resonator-based three-coil inductive link creates a homogeneous magnetic field that continuously delivers sufficient power (>2.7 mW) at an optimal carrier frequency of 60 MHz to the FF-WIOS in the near field without surpassing the specific absorption rate limit, regardless of the position of the FF-WIOS in a large brain area. Forward data telemetry carries stimulation parameters by on-off-keying the power carrier at a data rate of 50 kb/s to selectively activate a 4 × 4 μLED array. Load-shift-keying back telemetry controls the wireless power transmission by reporting the FF-WIOS received power level in a closed-loop power control mechanism. LEDs typically require high instantaneous power to emit sufficient light for optical stimulation. Thus, a switched-capacitor-based stimulation architecture is used as an energy storage buffer with one off-chip capacitor to receive charge directly from the inductive link and deliver it to the selected μLED at the onset of stimulation. The FF-WIOS system-on-a-chip prototype, fabricated in a 0.35-μm standard CMOS process, charges a 10-μF capacitor up to 5 V with 37% efficiency and passes instantaneous current spikes up to 10 mA in the selected μLED, creating a bright exponentially decaying flash with minimal wasted power. An in vivo experiment was conducted to verify the efficacy of the FF-WIOS by observing light-evoked local field potentials and immunostained tissue response from the primary visual cortex (V1) of two anesthetized rats.
Predictors of sick leave and improved worker productivity after 52 weeks of intensive treatment in patients with early rheumatoid arthritis

Objective: To identify predictors of sick leave and improved worker productivity in patients with early rheumatoid arthritis (RA) treated for 52 weeks with intensive combination strategies. Methods: Patients with early RA were included in the COmbinatietherapie Bij Reumatoïde Artritis (COBRA)-light trial and followed for 52 weeks. As the COBRA-light strategy proved to be non-inferior to the COBRA strategy, all patients were pooled. Predictors for sick leave and improved worker productivity were assessed through a 3 month time-lag multivariable logistic generalized estimating equations model. Results: At baseline, 97 patients had a paid job, 59 had no job, and for six patients the work status was unknown. During the trial, 13 patients stopped working (8%) and six started working (4%). Only sick leave in the past 3 months predicted sick leave. By excluding this variable, patient global assessment and actual hours of sick leave became predictors. Increased worker productivity was predicted by higher patient global assessment levels, Sharp van der Heijde score ≥ 1, actual hours on sick leave, and higher worker productivity in the past 3 months. Conclusion: Sick leave and improved worker productivity were mainly predicted by non-disease-specific variables. Both outcomes can be predicted on a 3 month basis, using the outcome over the past 3 months for the next 3 months. By applying this model in daily practice, decisions for therapy change could be based not solely on disease activity but also taking into account a possible high risk for sick leave in the upcoming 3 months.
Quality‐of‐life research in adult patients with congenital heart disease: current status and the way forward

Over the past four decades, the number of papers on quality of life (QoL) in congenital heart disease (CHD) has grown exponentially. However, firm conclusions have been hard to draw, because conceptual issues occurred and methodological differences prevented direct comparisons of studies. In general, QoL in CHD patients is good and it can be even better than in healthy peers when measured as life satisfaction. When QoL is measured as physical functioning, patients with complex CHD do worse than patients with moderate or mild defects or healthy individuals. APPROACH‐IS was a large‐scale international project that confirmed international variations in QoL, with Australian patients reporting the best QoL. Poor QoL was predicted by older age, being a job seeker, unemployed or disabled, never having married and those with worse functional status. Perceived illness and religion and spirituality were also significant predictors for QoL. On the other hand, country‐specific characteristics and healthcare system factors did not play a significant role in explaining variances in QoL of patients with CHD around the globe. Future studies should rely on a sound conceptual basis, use longitudinal research designs, be conducted in international, multi‐centre settings and evaluate interventions that promote patients’ QoL.
Retrospective Case Series of Traumatic Brain Injury and Post-Traumatic Stress Disorder Treated with Hyperbaric Oxygen Therapy

Returning veterans are frequently diagnosed with traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). Considering a recent case-controlled study of hyperbaric oxygen therapy (HBOT) reporting a reduction in suicidal ideation, we investigated retrospectively three veterans with chronic TBI/PTSD symptoms who were treated with multiple rounds of HBOT with neurophysiological testing performed before and after treatment. Improvements were detected on parameters within neurocognitive domains, including reductions in suicide-related symptoms. These findings independently confirm that HBOT may be effective in treating specific symptoms of TBI/PTSD that are not currently addressed with existing therapeutic approaches.
Genome Analysis of Entomopathogenic Bacillus sp. ABP14 Isolated from a Lignocellulosic Compost

Abstract We report the complete genome sequence of Bacillus sp. strain ABP14 isolated from lignocellulosic compost and selected by its ability in hydrolyzing carboxymethyl cellulose. This strain does not produce a Cry-like protein but showed an insecticidal activity against larvae of Anticarsia gemmatalis (Lepidoptera). Genome-based taxonomic analysis revealed that the ABP14 chromosome is genetically close to Bacillus thuringiensis serovar finitimus YBT020. ABP14 also carries one plasmid which showed no similarity with those from YBT020. Genome analysis of ABP14 identified unique genes related to cell surface structures, cell wall, metabolic competence, and virulence factors that may contribute for its survival and environmental adaptation, as well as its entomopathogenic activity.
Sword and Shield: Perceptions of law in empowering and protecting HIV-positive men who have sex with men in Manila, Philippines

ABSTRACT Legal protections for people living with HIV (PLHIV) are important for protecting human rights and combatting stigma. While much focus has been on the pernicious impacts of criminalisation of HIV transmission or nondisclosure, little research has accounted for the ways in which perception of protective laws may affect the everyday lives of PLHIV. The Philippines has the fastest growing HIV epidemic in the Asia & Pacific region, with HIV-positive men-who-have-sex-with-men (HIV+ MSM) bearing the majority of cases, and has recently revised their legal protections for PLHIV. We present findings from interviews with 21 HIV+ MSM in Manila, Philippines. Overall, participants viewed legal protections as both empowering and protective. Empowerment was achieved as protections helped participants manage internalised stigma, feel as if they had a weapon to fight discrimination, and perceive a more equitable climate around HIV within broader society. While participants felt as though the law sent positive signals that the government wanted to protect PLHIV, they doubted the actual legal process of bringing suits, leading to harms. Overall, this research presents ways in which legal protections can considered in interventions to empower PLHIV and also identifies opportunities to improve research and advocacy in settings with similarly protective laws.
Design techniques and methodologies for effective electromagnetic cleanliness in spacecraft power system

Electromagnetic compatibility (EMC) in electronics design is an indispensable aspect in the Design criteria/considerations of either terrestrial/ commercial systems/ equipments or Hi-Rel. systems like the spacecraft. EMC has a particular relevance to power systems design, as in most cases it is often the generator/source of Electrical/electromagnetic noise in any equipment or system. The predominant contributors to the electrical/electromagnetic noise, various effects of Electromagnetic noise in a Hi-rel. system like Spacecraft, the associated design guidelines/practices followed particularly in the spacecraft Power system design to minimize these effects of electromagnetic interference are briefly outlined. The Design techniques extends from basic choice of the materials, the associated fabrication/process methodologies, together with certain brute force methods of using additional components (Passive and active) to snub the amplitudes/excursions of the Electromagnetic noise and thereby aid in containment of the EMC levels. These methodologies are briefly explained. Power distribution is one of the major components of spacecraft power system. The type of wire/harness, the methodology of routing and the materials used contributes appreciably in the efforts aimed at the containment of electromagnetic noise. Generally radiation/arctarck resistant wires are used for high power lines, with live and return wires separately bundled and enclosed in additional layers of insulation before twisting to minimize the effects of electromagnetic noise for switching voltage/currents. As a basic precaution and guideline the power and signal lines in the wire harness are separated and enough care is taken to distribute' sensitive signal lines' through shielded wires. Generally in spacecraft power system a distributed Bus concept is preferred to centralized one, whereby individual users receive their power from the main bus via independent DC-DC converters. The DC-DC power converters and the Bus control is based on Switched mode concept from size and thermal management viewpoint, which is invariably accompanied by Electromagnetic noise. For the containment of this EM noise each power converters will have EMI filters both on the input and output sides. The switching elements, namely the Power transistors/MOSFETs of power conditioning/ control circuits and DC-DC converters are the main source of noise/EM interference on a spacecraft power Bus. Also the leakage inductance of the magnetic components, namely the inductors and transformers is the prime cause of the switching spikes which increases the levels of Electromagnetic noise. The use of snubbers across the switching elements, and the use of techniques like the Bifilar winding for transformers help in minimizing the switching noise amplitudes and aid in electromagnetic cleanliness.
Genetic modification to improve disease resistance in crops

Summary Plant pathogens are a significant challenge in agriculture despite our best efforts to combat them. One of the most effective and sustainable ways to manage plant pathogens is to use genetic modification (GM) and genome editing, expanding the breeder's toolkit. For use in the field, these solutions must be efficacious, with no negative effect on plant agronomy, and deployed thoughtfully. They must also not introduce a potential allergen or toxin. Expensive regulation of biotech crops is prohibitive for local solutions. With 11–30% average global yield losses and greater local impacts, tackling plant pathogens is an ethical imperative. We need to increase world food production by at least 60% using the same amount of land, by 2050. The time to act is now and we cannot afford to ignore the new solutions that GM provides to manage plant pathogens.
Angular Electrode Insertion Depth and Speech Perception in Adults With a Cochlear Implant: A Systematic Review

Objective: By discussing the design, findings, strengths, and weaknesses of available studies investigating the influence of angular insertion depth on speech perception, we intend to summarize the current status of evidence; and using evidence based conclusions, possibly contribute to the determination of the optimal cochlear implant (CI) electrode position. Data Sources: Our search strategy yielded 10,877 papers. PubMed, Ovid EMBASE, Web of Science, and the Cochrane Library were searched up to June 1, 2018. Both keywords and free-text terms, related to patient population, predictive factor, and outcome measurements were used. There were no restrictions in languages or year of publication. Study Selection: Seven articles were included in this systematic review. Articles eligible for inclusion: (a) investigated cochlear implantation of any CI system in adults with post-lingual onset of deafness and normal cochlear anatomy; (b) investigated the relationship between angular insertion depth and speech perception; (c) measured angular insertion depth on imaging; and (d) measured speech perception at, or beyond 1-year post-activation. Data Extraction and Synthesis: In included studies; quality was judged low-to-moderate and risk of bias, evaluated using a Quality-in-Prognostic-Studies-tool (QUIPS), was high. Included studies were too heterogeneous to perform meta-analyses, therefore, effect estimates of the individual studies are presented. Six out of seven included studies found no effect of angular insertion depth on speech perception. Conclusion: All included studies are characterized by methodological flaws, and therefore, evidence-based conclusions regarding the influence of angular insertion depth cannot be drawn to date.
Microenvironment and tumor inflammatory features improve prognostic prediction in gastro‐entero‐pancreatic neuroendocrine neoplasms

Microenvironment‐related immune and inflammatory markers, when combined with established Ki‐67 and morphology parameters, can improve prognostic prediction in gastro‐entero‐pancreatic neuroendocrine neoplasms (GEP‐NENs). Therefore, we evaluated the prognostic value of microenvironment and tumor inflammatory features (MoTIFs) in GEP‐NENs. For this purpose, formalin‐fixed paraffin‐embedded tissue sections from 350 patients were profiled by immunohistochemistry for immune, inflammatory, angiogenesis, proliferation, NEN‐, and fibroblast‐related markers. A total of 314 patients were used to generate overall survival (OS) and disease‐free survival (DFS) MoTIFs prognostic indices (PIs). PIs and additional variables were assessed using Cox models to generate nomograms for predicting 5‐year OS and DFS. A total of 36 patients were used for external validation of PIs and nomograms' prognostic segregations. From our analysis, G1/G2 versus G3 GEP‐NENs showed phenotypic divergence with immune‐inflammatory markers. HLA, CD3, CD8, and PD‐1/PD‐L1 IHC expression separated G3 into two sub‐categories with high versus low adaptive immunity‐related features. MoTIFs PI for OS based on COX‐2Tumor(T) > 4, PD‐1Stromal(S) > 0, CD8S < 1, and HLA‐IS < 1 was associated with worst survival (hazard ratio [HR] 2.50; 95% confidence interval [CI], 2.12–2.96; p < 0.0001). MoTIFs PI for DFS was based on COX‐2T > 4, PD‐1S > 4, HLA‐IS < 1, HLA‐IT < 2, HLA‐DRS < 6 (HR 1.77; 95% CI, 1.58–1.99; p < 0.0001). Two nomograms were developed including morphology (HR 4.83; 95% CI, 2.30–10.15; p < 0.001) and Ki‐67 (HR 11.32; 95% CI, 5.28–24.24; p < 0.001) for OS, and morphology (PI = 0: HR 10.23; 95% CI, 5.67–18.47; PI = 5: HR 2.87; 95% CI, 1.21–6.81; p < 0.001) and MoTIFs PI for DFS in well‐differentiated GEP‐NENs (HR 6.21; 95% CI, 2.52–13.31; p < 0.001). We conclude that G1/G2 to G3 transition is associated with immune‐inflammatory profile changes; in fact, MoTIFs combined with morphology and Ki‐67 improve 5‐year DFS prediction in GEP‐NENs. The immune context of a subset of G3 poorly differentiated tumors is consistent with activation of adaptive immunity, suggesting a potential for responsiveness to immunotherapy targeting immune checkpoints.
Simulate the Evolution of Scholarly Network via Agent-based Modeling

Agent-based modeling is a new modeling paradigm constituted by multiple autonomous agents and lots of basic rules to guide their behaviors and achieve their goals. In this paper, we propose a novel and ﬂexible simulation approach using agent-based modeling for future scholarly network prediction. This model includes three components. 1) Agent: we represent author and publication as heterogeneous and self-contained agents that can make decisions for their future behaviors; 2) Relation: we treat the connections in publication repository as heterogeneous relations between agents; 3) Rule: the most important component that governs all the agents’ behaviors and control the process of evolution. In accordance with the regulation of scholarly network evolution, we emphasize three generalized rules for future network simulation. Based on that, a series of speciﬁc rules combined with linear regression model and meta-path based random walk algorithm are elaborated on how to estimate new publications, how to compete for the coauthor and citation candidates and predict new links. Finally, the experiment results show that the proposed framework has a good performance on the simulation of future scholarly network.
Assessing Individual Variation in Action Identification: Translation, Validation, and Shortening of the Polish Behavior Identification Form (BIF)

Action identification theory asserts that level of action identification holds implications for important aspects of personality, including self-regulation, self-concept, and vulnerability to social influence. Vallacher and Wegner’s Behavior Identification Form is a 25-item forced-choice instrument that assesses individual differences in characteristic level of action identification and is widely used in social and psychological research. This article presents studies that evaluated the psychometric properties of the Polish version of the Behavior Identification Form, further modified it into a shortened version, and investigated several predicted conceptual relationships between the Behavior Identification Form and other personality measures. A total of 1153 Polish university students in three samples took part in the research. Psychometrically, the Polish Behavior Identification Form proved to be reasonably sound, with good internal consistency (avg. α = .83 and α = .72 for the full and short form, respectively). The predictive abilities of the full and short Polish Behavior Identification Form were consistently comparable, although not all of the expected associations were found.
On emotion recognition of faces and of speech using neural networks, fuzzy logic and the ASSESS system

We propose a framework for the processing of face image sequences and speech, using different dynamic techniques to extract appropriate features for emotion recognition. The features will be used by a hybrid classification procedure, employing neural network techniques and fuzzy logic, to accumulate the evidence for the presence of an emotional expression of the face and the speaker's voice.
Transepithelial versus epithelium-off corneal collagen cross-linking for corneal ectasia: protocol for a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials

Introduction Corneal ectasias are progressive, degenerative ocular diseases defined by abnormal structural changes in the cornea, leading to distortion of vision and substantial reduction in quality of life. Corneal collagen cross-linking (CXL) increases the biomechanical rigidity of the cornea and has been shown to halt ectatic processes. The established CXL protocol requires removal of the corneal epithelium. However, some surgeons have proposed transepithelial approaches to enhance patient recovery and minimise adverse events. Whether novel transepithelial approaches are as effective in arresting ectasia as the established epithelium-off protocol remains unclear. This study will systematically review the evidence on transepithelial CXL approaches and compare it to the epithelium-off protocol. Methods and analysis We will include randomised controlled trials (RCTs) comparing transepithelial and epithelium-off CXL for any corneal ectasia. We will search 16 electronic databases including MEDLINE and Embase, as well as the grey literature. Two reviewers will independently screen search results to identify eligible studies, complete data abstraction and conduct quality assessment. We will assess the quality of individual RCTs using the Cochrane risk of bias assessment tool. Our primary outcome will be the change in maximal keratometry at 12 months after treatment, and we will examine 11 additional outcomes. We will summarise our analyses by measures of association (relative risk or odds ratio) and corresponding 95% confidence intervals (CIs) for dichotomous outcomes and weighted mean differences with 95% CIs for continuous outcomes. Prespecified subgroup analyses will be conducted to explore heterogeneity. The overall quality of evidence will be rated using the Grading of Recommendations Assessment, Development and Evaluation approach. Ethics and dissemination Ethics approval is not required for this systematic review as it draws from previously published data. Results of the study will be submitted to a peer-reviewed journal for publication and discussed at conferences and seminars. PROSPERO registration number CRD42018102069