Miracle-dz/UniFAR-FTUs huggingface dataset:
Table image registration based on gradient projection

In this paper, we present an efficient and robust algorithm for document image registration, especially for table images. The projection-based method reduces the calculation complexity while also loses some information of the original image. The contribution of this paper is that our proposed method enhances the useful information in the projection using the image gradient feature. Besides, the rate of similarity (ROS) is presented to estimate the similarity between two images. Results of experiment show the practicality and efficiency of our proposed method.
Inflammation, oxidative stress, and insulin resistance in polycystic kidney disease.

BACKGROUND AND OBJECTIVES Most deaths in autosomal dominant polycystic kidney disease (ADPKD) are attributable to cardiovascular disease (CVD). We examined novel CVD biomarkers in different stages of ADPKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS We recruited 50 hypertensive subjects with ADPKD with estimated GFR (eGFR) of >60 ml/min per 1.73 m(2); 52 hypertensive subjects with ADPKD with eGFR of 25 to 60 ml/min per 1.73 m(2); 42 normotensive subjects with ADPKD and eGFR of >60 ml/min per 1.73 m(2); and 50 healthy controls. We assayed serum C-reactive protein and IL-6 as markers of inflammation; plasma 8-epi-prostaglandin F(2α (8-epi-PGF2α)) and superoxide dismutase (SOD) as markers of oxidative stress; and homeostasis model assessment (HOMA) as a measure of insulin resistance. RESULTS The hypertensive ADPKD eGFR of 25 to 60 group had higher levels of C-reactive protein and IL-6 than controls, normotensive ADPKD with eGFR of >60, and hypertensive ADPKD with eGFR of >60. The normotensive ADPKD eGFR >60, hypertensive ADPKD eGFR >60, and hypertensive ADPKD eGFR 25 to 60 groups had higher 8-epi-PGF(2α) and lower SOD than controls, with no difference between the ADPKD groups. There was no difference in HOMA levels between any of the groups. Adjustment for age, race, gender, and body mass index did not alter these relationships. CONCLUSIONS Inflammation and oxidative stress are evident early in ADPKD even with preserved kidney function. Inflammation exhibits a graded relationship with levels of kidney function, whereas oxidative stress demonstrates a threshold effect. These pathways may be therapeutic targets for CVD risk mitigation.
elephone-guided Self-Help Cognitive Behavioural Therapy for enopausal symptoms

Objectives: Group and Self-Help forms of Cognitive Behavioural Therapy (CBT) are effective treatment options for women with problematic menopausal hot flushes and night sweats (HF/NS). However, some women are unable to attend face-to-face sessions. This study investigates whether Self-Help CBT for HF/NS is as effective when rolled out to women living at a distance with minimal telephone guidance. Study design: Forty-seven women completed a Self-Help CBT intervention (booklet and relaxation/paced breathing CD) during a 4-week period. They also received one ‘guiding’ telephone call from a clinical psychologist two weeks into treatment to provide support and discuss individual treatment goals. Questionnaires were collected at baseline, 6 weeks (post-treatment) and 3 months (follow-up) after the end of the intervention. Main outcome measures: HF/NS problem rating. Secondary outcome measures: HF/NS frequency, HF/NS enopause ot flushes beliefs and behaviours, sleep, anxiety and depressed mood. Results: There was a significant reduction in HF/NS problem-rating following the intervention which was maintained at follow-up. Moreover, women reported less frequent HF/NS along with further improvements in sleep quality, mood and HF/NS beliefs and behaviours. Conclusions: Telephone-guided Self-Help interventions might provide an effective way of widening access S. to CBT treatment for HF/N
Recurrent Escherichia coli bacteraemia in a patient with chronic renal failure.

In July 1997, a 64-year-old Afro-Caribbean woman with chronic renal failure (CRF) managed by peritoneal dialysis presented with abdominal discomfort, weight loss, poor appetite, nausea, vomiting and pruritis. She had had chronic joint pain for many years which was treated with anti-inflammatory drugs, extensive and prolonged use of which was thought to have led to development of CRF. She described a 6–8 year history of vague abdominal pains which became subacute on occasion. Previous investigations, however, had not identified a cause. On this occasion her blood urea was high and this was thought to account for her symptoms and, as conservative management of her CRF had become increasingly difficult, she was switched to haemodialysis. Over the next 2 years, although the renal failure was adequately managed by haemodialysis, the clinical course worsened with low-grade pyrexia, episodes of coffee ground vomiting and confusion. On one occasion, the haemoglobin level was 9.8 gudl, total leucocyte count 15.1 3 10ul, eosinophil count 1.96 3 10ul (normal range; 0.04 –0.44) and platelet count 379 3 10ul. CT scan and CSF were normal. Upper gastrointestinal endoscopy showed haemorrhagic gastritis presumed to be secondary to aspirin, diclofenac and heparin. Her aspirin and diclofenac were stopped and she was treated with ranitidine, sucralfate and omeprazole which led to an improvement. However, at haemodialysis review she had recurrent pyrexia and persistent abdominal discomfort. In March 1999, blood culture from the Hickman line yielded Xanthomonas maltophilia which was effectively treated by line removal. However, a few days later, a repeat blood culture grew a sensitive Escherichia coli which was effectively treated with cefuroxime and gentamicin to which it was susceptible. Over the subsequent 6 months in response to a persistent pyrexia, blood cultures were taken in the out-patient department on 11 different occasions each separated by 2–6 weeks. Escherichia coli was cultured from the Hickman line and peripheral blood simultaneously. On each occasion, the patient was treated with antibiotics to which the respective organism was sensitive, and on each occasion this treatment led to a temporary resolution. The Hickman line was suspected as the source of these infective episodes and was replaced on a number of occasions. However, despite this the problem persisted. It was not until March 2000, that microscopy of urine and faeces revealed the organism shown in Figure 1 that the diagnosis became clear.
Leveraged BMIS Model for Cloud Risk Control

Cloud computing has increasingly been drawing attention these days. Each big company in IT hurries to get a chunk of meat that promises to be a whopping market in the future. At the same time, information is always associated with security and risk problems. Nowadays, the handling of these risks is no longer just a technology problem, with a good deal of literature focusing on risk or security management and framework in the information system. In this paper, we find the specific business meaning of the BMIS model and try to apply and leverage this model to cloud risk. Through a previous study, we select and determine the causal risk factors in cloud service, which are also known as CSFs (Critical Success Factors) in information management. Subsequently, we distribute all selected CSFs into the BMIS model by mapping with ten principles in cloud risk. Finally, by using the leverage points, we try to leverage the model factors and aim to make a resource-optimized, dynamic, general risk control business model for cloud service providers. Keywords—Cloud risk, CSFs, BMIS, Risk control, Leverage point, Effective model
Continuous EB welding of the reinforcement of the CMS conductor

The Compact Muon Solenoid (CMS) is one of the general-purpose detectors to be provided for the LHC project at CERN. The design field of the CMS superconducting magnet is 4 T, the magnetic length is 12.5 m and the free bore is 6 m. In order to withstand the electro-mechanical forces during the operation of the CMS magnet, the superconducting cable embedded in a 99.998% pure aluminum matrix is reinforced with two sections of aluminum alloy EN AW-6082 assembled by continuous Electron Beam Welding (EBW). A dedicated production line has been designed by Techmeta, a leading company in the field of EBW. The production line has a total length of 70 m. Non-stop welding of each of the 20 lengths of 2.5 km, required to build the coil, will last 22 hours. EBW is the most critical process involved in the production line. The main advantage of the EBW process is to minimize the Heat Affected Zone; this is particularly important for avoiding damage to the superconducting cable located only 4.7 mm from the welded joints. Two welding guns of 20 kW each operate in parallel in a vacuum chamber fitted with dynamic airlocks. After welding, the conductor is continuously machined on the four faces and on each corner to obtain the required dimensions and surface finish. Special emphasis has been put on quality monitoring. All significant production parameters are recorded during operation and relevant samples are taken from each produced length for destructive testing purposes. In addition, a continuous phased array ultrasonic checking device is located immediately after the welding unit for the continuous welding quality control, along with a dimension laser measurement unit following the machining.
Regulation of protein kinase C activity in neuronal differentiation induced by the N-ras oncogene in PC-12 cells

Expression of the N-ras oncogene under the control of the glucocorticoid-responsive promoter in the pheochromocytoma cell line UR61, a subline of PC-12 cells, has been used to investigate the differentiation process to neuronal cells triggered by ras oncogenes (I. Guerrero, A. Pellicer, and D. E. Burstein, Biochem. Biophys. Res. Commun. 150:1185-1192, 1988). Using ras-inducible cell lines, we observed that expression of the oncogenic N-ras p21 protein interferes with the ability of phorbol esters to induce downregulation of protein kinase C. This effect was associated with the appearance of immunologically detectable protein kinase C as well as the activity of the enzyme as analyzed either by binding of [3H]phorbol-12,13-dibutyrate in intact cells or by in vitro kinase activity. These results indicate a relationship between ras p21 and protein kinase C in neuronal differentiation in this model system. Comparison to the murine fibroblast system suggests that this relationship may be functional.
GHG emission reduction and global warming adaptation initiatives by UNFCCC

Climate change is undoubtedly one of the most ubiquitous and critical issues of the 21st century, demanding exigent attention to save the planet from global warming and its ominous effects. The Intergovernmental Panel on Climate Change (IPCC) identified the potential threat global warming poses, which led to the formation of United Nations Framework Convention on Climate Change (UNFCCC). Since its implementation, UNFCCC has made major contributions to improving the global climate change scenario. This paper attempts to shed light on the measures undertaken so far to combat global warming, the successes and failures, and the future projects.
Web Interactive Multimedia Technology Implementation: A University Context

Elluminate a web interactive multimedia technology (WIMT), was introduced in a large metropolitan university. The system incorporates several interactive and multimedia features. Those features when used in teaching and learning activities are categorised into five affordances: text, audio, video, image and screen-board. This system provides real time collaboration when used in a university teaching and learning environment as it enables immediate feedback between participants across physical space. This provides opportunities for interactivity and relationship building between academics and students, a vital component of learning. However, there are also several constraints in using WIMT. This paper discusses the findings from a case study conducted using a design science research approach. Semistructured interviews were employed to gather the implementer’s and adopter’s perspective on their use of WIMT. The findings demonstrate the benefits and challenges in using WIMT for teaching and learning activities. The practical description of experienced implementer and adopter can be used as a guide for others.
Implicit Memory for Odors: A Possible Method for Observation

In an experiment 143 subjects were instructed to assign odors to contexts which were displayed in a slide session. The slides depicted contexts from three areas of everyday life which party contained visual cues related to a presented odor. After rating the fit of each odor to a context, the subjects rated the odors for pleasantness. Analysis showed a strong influence of the visual cue on the rating of fit for the contexts containing an odor-related visual element. In contexts without a visual cue, rating of fit showed an influence of implicitly learned memories of odor. The rating was not affected by the pleasantness of the odors. The 1995 work of Schab and Crowder is critically reviewed, and results are discussed within the framework of new, more ecologically oriented research on memory for odor.
Weak-binding molecules are not drugs?—toward a systematic strategy for finding effective weak-binding drugs

Designing maximally selective ligands that act on individual drug targets with high binding affinity has been the central dogma of drug discovery and development for the past two decades. However, many low-affinity drugs that aim for several targets at the same time are found more effective than the high-affinity binders when faced with complex disease conditions, such as cancers, Alzheimer's disease and cardiovascular diseases. The aim of this study was to appreciate the importance and reveal the features of weak-binding drugs and propose an integrated strategy for discovering them. Weak-binding drugs can be characterized by their high dissociation rates and transient interactions with their targets. In addition, network topologies and dynamics parameters involved in the targets of weak-binding drugs also influence the effects of the drugs. Here, we first performed a dynamics analysis for 33 elementary subgraphs to determine the desirable topology and dynamics parameters among targets. Then, by applying the elementary subgraphs to the mitogen-activated protein kinase (MAPK) pathway, several optimal target combinations were obtained. Combining drug-target interaction prediction with molecular dynamics simulation, we got two potential weak-binding drug candidates, luteolin and tanshinone IIA, acting on these targets. Further, the binding affinity of these two compounds to their targets and the anti-inflammatory effects of them were validated through in vitro experiments. In conclusion, weak-binding drugs have real opportunities for maximum efficiency and may show reduced adverse reactions, which can offer a bright and promising future for new drug discovery.
A PHOTOREACTIVATIONLESS MUTANT OF SACCHAROMYCES CEREVISIAE *, †

Abstract— A mutant of S. cerevisiue has been isolated that is incapable of photoreactivating u.v. ‐induced lethal damage. The mutant resulted from mutation of the chromosomal gene PHR 1, which was determined to be dominant. This gene is involved with the production of photoreactivating enzyme.
Recurrent Neural Network-Based Phoneme Sequence Estimation Using Multiple ASR Systems' Outputs for Spoken Term Detection

This paper describes a novel correct phoneme sequence estimation method that uses a recurrent neural network (RNN)-based framework for spoken term detection (STD). In an automatic speech recognition (ASR)-based STD framework, ASR performance (word or subword error rate) affects STD performance. Therefore, it is important to reduce ASR errors to obtain good STD results. In this study, we use an RNN-based phoneme estimator, which estimates a correct phoneme sequence of an utterance from some sorts of phoneme-based transcriptions produced by multiple ASR systems in post-processing, to reduce phoneme errors. With two types of test speech corpora, the proposed phoneme estimator obtained phoneme-based N-best transcriptions with fewer phoneme recognition errors than the N-best transcriptions from the best ASR system we prepared. In addition, the STD system with the RNN-based phoneme estimator drastically improved STD performance with two test collections for STD compared to our previously proposed STD system with a conditional random fields-based phoneme estimator.
Analysis of transcription termination signals in the nin region of bacteriophage lambda: the roc deletion

Deletions in the region, nin, between the P and Q genes of phage lambda remove a portion of the phage genome that includes signals for termination of transcription. These deletions were selected because they permit growth of lambda derivatives defective in the N-mediated transcription antitermination system; i.e., the deletions confer N independence (nin). Thus nin phages (e.g., lambda nin5) grow in most Escherichia coli nus mutants. The nus genes encode functions necessary for N action. We report the isolation of a deletion in the nin region delta roc that confers a partially N-independent phenotype; lambda derivatives with delta roc can grow under normally nonpermissive conditions, 32 degrees C, in a host with the rpoB-nusC60 mutation. The roc deletion also partially suppresses the inhibitory effects of other nus mutations at higher temperatures. Delta roc, which extends from base pairs 41883 to 43825, overlaps the nin5 deletion, which extend from base pairs 40501 to 43306. Unlike the nin5 deletion, the sequences deleted by delta roc do not include a stem-loop structure, tR2, previously shown to have terminator activity. Using promoter and terminator testor vectors, we demonstrate that a 2,400-base-pair fragment that includes the wild-type roc region but excludes tR2 has terminator activity. Thus, delta roc permits a functional division of the transcription termination signals in the nin region.
Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFkappaB: implications for tolerance induction.

BACKGROUND Recent experimental data indicate that the targeting of the costimulatory molecule CD40-ligand (CD154) may well offer an opportunity for tolerance induction in transplant recipients and patients with autoimmune diseases, although the optimal therapeutic strategy for clinical application of CD154 monoclonal antibody (mAb) is unclear. METHODS We undertook vascularized heterotopic cardiac allograft transplantation in completely MHC-mismatched mice, treated recipients with CD154 mAb plus various immunosuppressive agents, and performed flow cytometric analysis of CD154 expression by T cells activated in vitro in the presence of corresponding immunosuppressive agents. We also tested the extent to which CD154 induction was NFkappaB-dependent by using NFkappaB/p50-deficient mice as allograft recipients and as source of cells for in vitro studies of CD154 induction, and through use of proteasome inhibitors to block IkappaBalpha degradation and NFKB activation in wild-type mice. RESULTS Concomitant use of cyclosporin A or methylprednisolone, but not rapamycin or mycophenolate, inhibited CD154 mAb-induced allograft survival. The differential effects of these agents on CD154 mAb-induced tolerance correlated with their capacity to inhibit activation-induced CD154 expression on CD4+ T cells. Full expression of CD154 expression was found to require NF-kappaB activation, and CD154 mAb was ineffective in NF-kappaB/p50 deficient allograft recipients or control mice in which NF-kappaB activation was blocked by proteasome inhibition. CONCLUSIONS Strategies to use CD154 mAb clinically must take into account the effects of immunosuppressive agents on CD154 induction, which seems to be at least partially NF-kappaB dependent. Our data suggest that ligation of surface-expressed CD154 provides an important signal that modulates T cell activation and thereby contributes to the effects of CD154 mAb, in addition to previously recognized actions involving blockade of CD40/CD154-dependent cell activation and activation-induced cell death.
Hypokalemic paralysis and osteomalacia secondary to renal tubular acidosis in a case with primary Sjögren's syndrome

A 39-year-old Japanese woman was admitted to our hospital for severe weakness owing to potassium deficiency caused by type 1 renal tubular acidosis (RTA1). Sicca complex, serological tests, and lip biopsy revealed that she had Sjögren's syndrome (SS). Acidosis was corrected by alkali supplement treatment. She also had an impaired renal function with proteinuria, and high absorbance on Ga scintigram was recognized in both kidneys. She was taking warfarin potassium after aortic valve substitution due to aortic regurgitation, therefore renal biopsy was not performed. Prednisone (20 mg/day) was administered for renal inflammation. One month later, she suffered severe chest wall pains with some local tender points over the costae of both sides, which was presumed to be due to pseudofractures based on osteomalacia. Hypokalemic paralysis and osteomalacia should be taken into consideration in the diagnosis of SS with RTA1.
Transfer of the Long Head of the Triceps Tendon for Irreparable Rotator Cuff Tears

This study presents the clinical and anatomic findings of the use of the long head of the triceps tendon for treatment of massive, irreparable rotator cuff tears. The clinical study included 19 shoulders in 18 patients with a minimum followup of 2 years who were prospectively reviewed. All patients had preoperative and postoperative functional evaluations using the UCLA scoring system. The anatomic study included 20 upper extremities that had been injected with Microfil. All patients in the clinical study were satisfied with their outcome. There was an improvement in the UCLA pain and function scores. The long head of the triceps tendon is a myotendinous vascularized transfer that is a useful reconstructive procedure in patients with massive, irreparable rotator cuff tears that continue to be symptomatic despite conventional attempts at repair.
Hybrid logarithmic number system arithmetic unit: A review

Logarithmic number system (LNS) arithmetic has the advantages of high performance and high-precision in complex function computation. However, the large hardware problem in LNS addition/subtraction computation has made the large word-length LNS arithmetic implementation impractical. In this paper, the concept of merging the LNS and Floating Point (FLP) operation into a single arithmetic logic unit (ALU) that can execute addition/subtraction and division/multiplication more faster, precise and less complicated has been reviewed. The advantages of using hybrid system were highlighted while comparing and explaining about FLP and LNS.
Chemoenzymatic synthesis of GDP-l-fucose and the Lewis X glycan derivatives

Lewis X (Lex)-containing glycans play important roles in numerous cellular processes. However, the absence of robust, facile, and cost-effective methods for the synthesis of Lex and its structurally related analogs has severely hampered the elucidation of the specific functions of these glycan epitopes. Here we demonstrate that chemically defined guanidine 5′-diphosphate-β-l-fucose (GDP-fucose), the universal fucosyl donor, the Lex trisaccharide, and their C-5 substituted derivatives can be synthesized on preparative scales, using a chemoenzymatic approach. This method exploits l-fucokinase/GDP-fucose pyrophosphorylase (FKP), a bifunctional enzyme isolated from Bacteroides fragilis 9343, which converts l-fucose into GDP-fucose via a fucose-1-phosphate (Fuc-1-P) intermediate. Combining the activities of FKP and a Helicobacter pylori α1,3 fucosyltransferase, we prepared a library of Lex trisaccharide glycans bearing a wide variety of functional groups at the fucose C-5 position. These neoglycoconjugates will be invaluable tools for studying Lex-mediated biological processes.