Miracle-dz/UniFAR-FTUs huggingface dataset:
Iterative calculation of electromagnetic processes in the current transformer by the approximated magnetization curve

The article gives a general analysis of the most common international practice models of electromagnetic processes disadvantages in current transformers. On the basis of these results, the authors have proposed more simpler and practical mathematical models and algorithms. These models make it possible to consider the residual magnetic induction in the current transformer, to determine all the necessary characteristics of relay protection current transformer for use in engineering. Also these models require minimal computational cost. Numerical methods for differentiation and integration laid the foundation to Models proposed by the author. Capabilities and effectiveness of the proposed models are shown by the example of the current transformer type TFNK - 330.
Identification of the Drosophila interband-specific protein Z4 as a DNA-binding zinc-finger protein determining chromosomal structure

The subdivision of polytene chromosomes into bands and interbands suggests a structural chromatin organization that is related to the formation of functional domains of gene expression. We made use of the antibody Z4 to gain insight into this level of chromosomal structure, as the Z4 antibody mirrors this patterning by binding to an antigen that is present in most interbands. The Z4 gene encodes a protein with seven zinc fingers, it is essential for fly development and acts in a dose-dependent manner on the development of several tissues. Z4 mutants have a dose-sensitive effect on wm4 position effect variegation with a haplo-suppressor and triplo-enhancer phenotype, suggesting Z4 to be involved in chromatin compaction. This assumption is further supported by the phenotype of Z4 mutant chromosomes, which show a loss of the band/interband pattern and are subject to an overall decompaction of chromosomal material. By co-immunoprecipitations we identified a novel chromo domain protein, which we named Chriz (Chromo domain protein interacting with Z4) as an interaction partner of Z4. Chriz localizes to interbands in a pattern that is identical to the Z4 pattern. These findings together with the result that Z4 binds directly to DNA in vitro strongly suggest that Z4 in conjunction with Chriz is intimately involved in the higher-order structuring of chromosomes.
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

Initiation of the innate immune response requires agonist recognition by pathogen-recognition receptors such as the Toll-like receptors (TLRs). Toll/interleukin-1 receptor (TIR) domain-containing adaptors are critical in orchestrating the signal transduction pathways after TLR and interleukin-1 receptor activation. Myeloid differentiation primary response gene 88 (MyD88) adaptor-like (MAL)/TIR domain-containing adaptor protein (TIRAP) is involved in bridging MyD88 to TLR2 and TLR4 in response to bacterial infection. Genetic studies have associated a number of unique single-nucleotide polymorphisms in MAL with protection against invasive microbial infection, but a molecular understanding has been hampered by a lack of structural information. The present study describes the crystal structure of MAL TIR domain. Significant structural differences exist in the overall fold of MAL compared with other TIR domain structures: A sequence motif comprising a β-strand in other TIR domains instead corresponds to a long loop, placing the functionally important “BB loop” proline motif in a unique surface position in MAL. The structure suggests possible dimerization and MyD88-interacting interfaces, and we confirm the key interface residues by coimmunoprecipitation using site-directed mutants. Jointly, our results provide a molecular and structural basis for the role of MAL in TLR signaling and disease protection.
CD4+ Lymphocytes and Gamma Interferon Predominate in Local Immune Responses in Early Experimental Syphilis

ABSTRACT The clearance of Treponema pallidum subsp. pallidum from early syphilis lesions involves infiltration of a large number of mononuclear cells and is characteristic of a cell-mediated immune response. In the present study, we sought to determine the relative abundance of different T-lymphocyte populations and Th1/Th2-associated cytokines present in testicular lesions following experimental infection with the Chicago strain of T. pallidum. Using flow cytometry, we examined the proportion of CD4+ and CD8+ T cells present throughout the progression and resolution of primary syphilis in the rabbit model. We related these findings to the results of real-time reverse transcription-PCR quantification of treponemal and cytokine mRNA levels. Treponemal mRNA levels reached peak values on day 18 postinfection, coincident with an initial peak in the level of T cells, which were primarily CD4+ T cells. T-cell levels increased again during resolution of orchitis, and there was an increased proportion of CD8+ T cells. The maximum gamma interferon (IFN-γ) and interleukin-10 (IL-10) mRNA levels were observed on days 11 and 18, respectively, while only negligible amounts of IL-4 and IL-2 were detected throughout the infection. In addition to showing the temporal relationship between treponemal burden and T-cell responses during lesion progression, our results also demonstrate that the composition of the T-cell population changes during lesion resolution. The presence of the mRNA for IFN-γ, but not IL-4, is consistent with cytokine expression in human syphilis and provides further support for the hypothesis that there is a Th1 predominance during the early immune response to T. pallidum.
Genome Sequences of Three Strains of the Pseudomonas aeruginosa PA7 Clade

ABSTRACT Draft genome sequences of three P. aeruginosa strains from the PA7 clade are presented here. Their lengths are 6.36 (EML528), 6.44 (EML545), and 6.33 Mb (EML548). Comparisons with the PA7 genome showed 5,113 conserved coding sequences (CDSs), and significant numbers of strain-specific CDSs. Their analysis will improve our understanding of this highly divergent clade.
Anti-rheumatoid Activity of Secondary Metabolites Produced by Endophytic Chaetomium globosum

The aim of the present study was to investigate the anti-rheumatoid activity of secondary metabolites produced by endophytic mycobiota in Egypt. A total of 27 endophytic fungi were isolated from 10 dominant medicinal plant host species in Wadi Tala, Saint Katherine Protectorate, arid Sinai, Egypt. Of those taxa, seven isolates of Chaetomium globosum (CG1–CG7), being the most frequent taxon, were recovered from seven different host plants and screened for production of active anti-inflammatory metabolites. Isolates were cultivated on half – strength potato dextrose broth for 21 days at 28°C on a rotatory shaker at 180 rpm, and extracted in ethyl acetate and methanol, respectively. The probable inhibitory effects of both extracts against an adjuvant induced arthritis (AIA) rat model were examined and compared with the effects of methotrexate (MTX) as a standard disease-modifying anti-rheumatoid drug. Disease activity and mobility scoring of AIA, histopathology and transmission electron microscopy (TEM) were used to evaluate probable inhibitory roles. A significant reduction (P < 0.05) in the severity of arthritis was observed in both the methanolic extract of CG6 (MCG6) and MTX treatment groups 6 days after treatment commenced. The average arthritis score of the MCG6 treatment group was (10.7 ± 0.82) compared to (13.8 ± 0.98) in the positive control group. The mobility score of the MCG6 treatment group (1.50 ± 0.55) was significantly lower than that of the positive control group (3.33 ± 0.82). In contrast, the ethyl acetate extract of CG6 (EACG6) treatment group showed no improvements in arthritis and mobility scores in AIA model rats. Histopathology and TEM findings confirmed the observation. Isolate CG6 was subjected to sequencing for confirmation of phenotypic identification. The internal transcribed spacer (ITS) 1–5.8 s – ITS2 rDNA sequences obtained were compared with those deposited in the GenBank Database and registered with accession number KC811080 in the NCBI Database. The present study revealed that the methanol extract of endophytic fungus C. globosum (KC811080) recovered from maidenhair fern has an inhibitory effect on inflammation, histopathology and morphological features of rheumatoid arthritis in an AIA rat model.
Imagery Interference Diminishes in Older Adults: Age-Related Differences in the Magnitude of the Perky Effect

Studies have documented the negative effects of mental imagery on perception (also known as the Perky effect) in younger adults, but imagery-interference effects in older adults have never been assessed. Two experiments examined this issue directly. Experiment 1 demonstrated that visual mental images diminish visual acuity in younger adults (mean age = 19.0) but not older adults (mean age = 73.6). Experiment 2 obtained parallel results, showing that visual imagery interfered with performance on a visual detection task in younger (mean age = 18.7) but not older adults (mean age = 66.7). Processes underlying age-related differences in imagery-interference effects are discussed and implications of these results for changes in cognitive performance in older adults are considered.
The role of biodevelopmental and psychological factors in disordered eating among adolescent males and females

The present study examined the role of biodevelopmental and psychological factors in the development of disordered eating in early adolescent males and females. Three hundred and six girls (mean age = 13.66 years; SD = 1.12 years) and 297 boys (mean age = 13.89 years; SD = 1.13 years) from grades 7–10 completed a questionnaire which assessed disordered eating, biodevelopmental (body mass index (BMI), age and puberty) and psychological factors (self-esteem, depression, anxiety, ineffectiveness, perfectionism). Not surprisingly, girls were more likely than boys to engage in extreme weight loss behaviours. There were no significant differences between boys and girls on measures of binge eating or bulimic tendencies. Self-esteem, depression and anxiety were found to be significant predictors of disordered eating among girls, while anxiety, ineffectiveness, self-esteem and perfectionism were significant predictors among boys. The findings from this study demonstrate the importance of psychological variables in predicting extreme weight loss behaviours among both adolescent males and females. Copyright © 2003 John Wiley & Sons, Ltd and Eating Disorders Association.
Cellular mechanism for spontaneous calcium oscillations in astrocytes

AbstractAim:To determine the Ca2+ source and cellular mechanisms of spontaneous Ca2+ oscillations in hippocampal astrocytes.Methods:The cultured cells were loaded with Fluo-4 AM, the indicator of intracellular Ca2+, and the dynamic Ca2+ transients were visualized with confocal laser-scanning microscopy.Results:The spontaneous Ca2+ oscillations in astrocytes were observed first in co-cultured hippocampal neurons and astrocytes. These oscillations were not affected by tetrodotoxin (TTX) treatment and kept up in purity cultured astrocytes. The spontaneous Ca2+ oscillations were not impacted after blocking the voltage-gated Ca2+ channels or ethylenediamine tetraacetic acid (EDTA) bathing, indicating that intracellular Ca2+ elevation was not the result of extracellular Ca2+ influx. Furthermore, the correlation between the spontaneous Ca2+ oscillations and the Ca2+ store in endoplasmic reticulum (ER) were investigated with pharmacological experiments. The oscillations were: 1) enhanced when cells were exposed to both low Na+ (70 mmol/L) and high Ca2+ (5 mmol/L) solution, and eliminated completely by 2 μmol/L thapsigargin, a blocker of sarcoplasmic reticulum Ca2+-ATPase; and 2) still robust after the application with either 50 μmol/L ryanodine or 400 μmol/L tetracaine, two specific antagonists of ryanodine receptors, but depressed in a dose-dependent manner by 2-APB, an InsP3 receptors (InsP3R) blocker.Conclusion:InsP3R-induced ER Ca2+ release is an important cellular mechanism for the initiation of spontaneous Ca2+ oscillation in hippocampal astrocytes.
Engineering JavaScript state persistence of web applications migrating across multiple devices

Ubiquitous environments call for user interfaces able to migrate across various types of devices while preserving task continuity. One fundamental issue in migratory user interfaces is how to preserve the state while moving from one device to another. In this paper we present a solution for the interactive part of Web applications. In particular, we focus on the most problematic part, which is maintaining the JavaScript state. We also describe an example application to illustrate the support provided by our migration platform.
An Iterative Jackknife Approach for Assessing Reliability and Power of fMRI Group Analyses

For functional magnetic resonance imaging (fMRI) group activation maps, so-called second-level random effect approaches are commonly used, which are intended to be generalizable to the population as a whole. However, reliability of a certain activation focus as a function of group composition or group size cannot directly be deduced from such maps. This question is of particular relevance when examining smaller groups (<20–27 subjects). The approach presented here tries to address this issue by iteratively excluding each subject from a group study and presenting the overlap of the resulting (reduced) second-level maps in a group percent overlap map. This allows to judge where activation is reliable even upon excluding one, two, or three (or more) subjects, thereby also demonstrating the inherent variability that is still present in second-level analyses. Moreover, when progressively decreasing group size, foci of activation will become smaller and/or disappear; hence, the group size at which a given activation disappears can be considered to reflect the power necessary to detect this particular activation. Systematically exploiting this effect allows to rank clusters according to their observable effect size. The approach is tested using different scenarios from a recent fMRI study (children performing a “dual-use” fMRI task, n = 39), and the implications of this approach are discussed.
A 4WD omnidirectional wheelchair with a chair tilting system

This paper presents a development of a 4WD omnidirectional wheelchair with a chair tilting system for climbing single high step. For enhancing the step climb capability of standard wheelchairs, a Four-wheel-drive(4WD) mechanism is introduced. The mobile platform equips four wheels. A pair of front-rear wheels which mounted on the same side of the mechanism, are interconnected by belt transmissions to rotate in unison with a drive motor, i.e. a synchro-drive transmission. To avoid slippage of wheels on the ground, two omni-wheels are installed in front while two normal tires are equipped in rear, which configuration enables the free sliding of the front side of the mobile mechanism while the rear two wheels are guaranteed confirmed contacting to the ground at all times. Additionally, to rotate a chair at the center of the mobile base about vertical axis, the third motor is installed on the 4WD platform.
Incidence of Salmonella on Reptiles in the Pet Trade

UNL School of Natural Resources, dferraro@unlnotes.unl. eduCopyright c 2009 by the authors. All rights reserved. No part of this publicationmay be reproduced, stored in a retrieval system, or transmitted, in any form or byany means, electronic, mechanical, photocopying, recording, or otherwise, without theprior written permission of the publisher, bepress, which has been given certain ex-clusive rights by the author. RURALS: Review of Undergraduate Research in Agri-cultural and Life Sciences is produced by The Berkeley Electronic Press (bepress). http://digitalcommons.unl. edu/rurals
Semi-supervised sparse metric learning using alternating linearization optimization

In plenty of scenarios, data can be represented as vectors and then mathematically abstracted as points in a Euclidean space. Because a great number of machine learning and data mining applications need proximity measures over data, a simple and universal distance metric is desirable, and metric learning methods have been explored to produce sensible distance measures consistent with data relationship. However, most existing methods suffer from limited labeled data and expensive training. In this paper, we address these two issues through employing abundant unlabeled data and pursuing sparsity of metrics, resulting in a novel metric learning approach called semi-supervised sparse metric learning. Two important contributions of our approach are: 1) it propagates scarce prior affinities between data to the global scope and incorporates the full affinities into the metric learning; and 2) it uses an efficient alternating linearization method to directly optimize the sparse metric. Compared with conventional methods, ours can effectively take advantage of semi-supervision and automatically discover the sparse metric structure underlying input data patterns. We demonstrate the efficacy of the proposed approach with extensive experiments carried out on six datasets, obtaining clear performance gains over the state-of-the-arts.
Characterization of the electromagnetic response of maize crops with polarimetric backscatter profiles

An exhaustive analysis of the electromagnetic response from a maize sample, measured in laboratory conditions, is presented. Fully polarimetric wide-band radar data have been collected in order to compute backscatter profiles (i.e. 1D images) as a function of height. First results consist on backscatter images expressed in Pauli and linear basis. These plots demonstrate that the extinction coefficient is higher for vertical polarization than for horizontal polarization due to the predominant vertical orientations of the components of the corn plants (mainly the stems). In addition, the crosspolar backscattered power decreases importantly as the frequency increases, and it is always lower than the copolar returns, again as a result of the oriented morphology, which produces a very low depolarization of the signal. On the other hand, the second kind of results is based on the polarimetric target decomposition proposed by Cloude and Pottier. Height profiles of alpha, entropy and anisotropy have been calculated. These parameters have been carefully analyzed in order to extract information to be used in the application of parameters inversion algorithms
Effects of MyTeachingPartner–Math/Science on Teacher–Child Interactions in Prekindergarten Classrooms

ABSTRACT Research Findings: This study examined the impact of MyTeachingPartner–Math/Science, a system of math and science curricula and professional development, on the quality of teachers’ interactions with children in their classrooms. Schools were randomly assigned to 1 of 2 intervention conditions (Basic: curricula providing within-activity, embedded teacher supports; Plus: curricula plus implementation support via online resources and in-person workshops) or to a Business-as-Usual (BaU) control condition. Results showed that teachers in the Basic and Plus conditions showed higher levels of Instructional Support and Facilitation of Mathematical and Scientific Thinking. Teachers in the Basic condition also showed higher levels of Emotional Support compared with teachers in the BaU condition. We did not find any significant differences between teachers’ interactions in the Basic and Plus conditions. Practice or Policy: Children are entering kindergarten unprepared in the areas of mathematics and science, largely as a result of inadequate exposure to early experiences and high-quality interactions in these domains. The results of this study suggest that providing teachers with math and science curricula that include embedded teacher supports can have an impact on the quality of their math and science instruction.
Men reading fiction : a study of the relationship between reader, (con)text, consumption and gender identity

This thesis is a qualitative study of men's talk about fiction reading. Based on 38 interviews with male readers and 13 book group sessions with four male participants it draws upon the theories of Bourdieu (1986) and de Certeau (1988) to analyse how men's consumption practices may in part be constitutive of articulations of gendered identity. My analysis of the qualitative data begins with a focus on the interviews, looking at how Bourdieu's conceptual apparatus can be extended to look at the power of the media as a form of 'meta-capital' (Couldry 2003) and gender as a form of symbolic power. The interview analysis identifies a link between gender and genre, with masculinity articulated by negation of culturally feminised texts. Moving towards a more specific analysis of the articulation of the self as gendered, I then consider how the book group participants talk about a series of texts. Firstly focusing on culturally masculinised genres (horror, techno-thriller, science fiction and militaristic action/adventure) the group discussions measured the value of a text by how 'realistic' it was. Subsequently the book group participants were asked to make their own selections to focus on the 'symbolic work' (Willis 2000) of consumption. Each of the books chosen contained elements of comedy pointing to the importance of this genre to performances of masculinity. The readers also revoked their previously established valuation of 'realism' in favour of proximity to the text. Finally, the analysis turns to culturally feminised genres (modern romance, chick lit, feminist fiction, and a 'classic' romantic comedy) where discussions once more emphasised readers' constructions of self in opposition to femininity.
Distribution and characterization of IL-10-secreting cells in lymphoid tissues of PCV2-infected pigs

Distribution and characterization of interlukin-10 (IL-10)-secreting cells in lymphoid tissues of pigs naturally infected with porcine circovirus type 2 (PCV2) were evaluated in accordance with PCV2 antigen detection. After screening a total of 56 pigs showing the symptoms of postweaning multisystemic wasting syndrome (PMWS), 15 pigs were PCV2 positive and 5 pigs, which showed stronger positive signals over multiples tissues were further investigated. This study showed that in PCV2-infected lymphoid tissues, particularly mandibular lymph node, spleen and tonsil, IL-10 expression was mainly localized in T-cell rich areas but rarely in B cell rich areas. IL-10 was highly expressed in bystander cells but rarely in PCV2-infected cells. Elevated IL-10 expression was predominantly associated with T cells, but rarely with B cells or with macrophages. The results of this study provide evidence for the role of IL-10 in chronic PCV2 infection and its relation to PCV2 antigen in affected tissues. Constantly elevated levels of IL-10 lead to immunosuppression in persistent and chronic viral infections. The increased IL-10 expression observed in PCV2 infection in this study suggests that IL-10-mediated immunosuppression may play an important role in the pathogenesis and maintenance of naturally occurring PCV2 infection.