Miracle-dz/UniFAR-FTUs huggingface dataset:
Variability-aware dark silicon management in on-chip many-core systems

Dark Silicon refers to the constraint that only a fraction of on-chip resources (cores) can be simultaneously powered-on (running at full performance) in order to stay within the allowable power budget and safe temperature limits, while others remain `dark'. In this paper, we demonstrate how these `dark cores' can be leveraged to improve the temperature profile at run-time, thus providing opportunities to power-on more cores at the nominal voltage than the number allowed when strictly obeying the conventional Thermal Design Power (TDP) constraint. In this paper, we propose a computationally efficient dark silicon management technique that determines the best set of cores to keep dark and the mapping of threads to cores at run-time, while also accounting for the impact of process variations. We have developed a lightweight temperature prediction mechanism that determines the impact of different candidate solutions on the chip thermal profile. Experimental evaluation of the proposed techniques on a simulated 8×8 many-core processor, and across a range of chips to account for process variations, show that the total instruction throughput is increased by 1.8× on average while keeping the temperature within the safe limits, when compared with state-of-the-art approaches.
The enduring legacy of Alma Ata: 30 years on

The 1978 Alma Ata conference and declaration was a landmark in defining and providing a direction for primary healthcare. Despite the initial enthusiasm for Alma Ata, its impact appeared to have declined in the 1990s. However, in recent years, there has been a revitalisation of primary healthcare. This article reviews the Alma Ata conference and declaration, assesses its waxing and waning, and examines its recent revival. The paper draws conclusions about the relevance of Alma Ata, 30 years on.
Haemodialysis-induced pseudoporphyria successfully treated with glutathione.

ejd.2011. 1571 Auteur(s) : Akira Kasuya casuaki@hama-med.ac. jp, Hideo Hashizume, Satoshi Hirakawa, Yoshiki Tokura Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashi-Ku, Hamamatsu 431-3192, Japan Pseudoporphyria is a blistering disease, which is clinically and pathologically similar to porphyria cutanea tarda [1-3]. However, porphyrin levels of pseudoporphyria are normal or nearly normal in serum, urine, and stools. Pseudoporphyria is frequently associated with [. ]
Detector response restoration in image reconstruction of high resolution positron emission tomography

A mathematical method was studied to model the detector response of high spatial-resolution positron emission tomography systems consisting of close-packed small crystals, and to restore the resolution deteriorated due to crystal penetration and/or nonuniform sampling across the field-of-view (FOV). The simulated detector system had 600 bismuth germanate crystals of 3.14 mm width and 30 mm length packed on a single ring of 60 cm diameter. The space between crystals was filled up with lead (i.e., septa). Each crystal was in coincidence with 200 opposite crystals so that the FOV had a radius of 30 cm. The detector response was modeled based on the attenuating properties of the crystals and the septa, as well as the geometry of the detector system. The modeled detector-response function was used to restore the projections from the sinogram of the ring-detector system. The restored projections had a uniform sampling of 1.57 mm across the FOV. The crystal penetration and/or the nonuniform sampling were compensated in the projections. A penalized maximum-likelihood algorithm was employed to accomplish the restoration. The restored projections were then filtered and backprojected to reconstruct the image. A chest phantom with a few small circular "cold" objects ( approximately 4 mm diameter) located at the center and near the periphery of FOV was computer generated and used to test the restoration. The reconstructed images from the restored projections demonstrated resolution improvement off the FOV center, while preserving the resolution near the center.
Multi-Camera Action Dataset (MCAD): A Dataset for Studying Non-overlapped Cross-Camera Action Recognition

Action recognition has received increasing attentions from the computer vision and machine learning communities in the last decades. To enable the study of this problem, there exist a vast number of action datasets, which are recorded under the controlled laboratory environment, the real-world surveillance environment, or crawled from the Internet. Most of these datasets are recorded using one camera, or simultaneously recorded with the same action with multiple overlapped cameras. This results in that the training and test data are often resemble similar environment conditions. In this paper, we introduce a new dataset, namely Multi-Camera Action Dataset (MCAD), which is designed to evaluate the open view classification problem under the surveillance environment. Specifically, it enable researchers to study the robustness of exiting algorithm for actions that are recorded from multiple cameras with similar Field-of-View (FOV) and environment conditions. This dataset contains 14,298 action samples from 18 action categories, including 9 classes of single person actions and 9 classes of person-object actions, which are performed by 20 subjects and recorded with 5 cameras. Inspired by the well received evaluation approach on the LFW dataset, we design a standard evaluation protocol to enable comparisonagainst existing works.
Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells

A new biochemical method for estimating the virtual number of mitochondria (mt) per cell was developed and used together with a plasmid probe to measure mt DNA/mitochondrion and mt DNA/cell. These methods were used in five cell types from four mammalian species. Mt DNA/mitochondrion was essentially constant in all cell types (mean 2.6 ± 0.30 SE mitochondrial DNA molecules/mt). Mt DNA molecules/cell encompassed an eight‐fold range between various cell types (low 220 ± 6.2; high 1,720 ± 162 mt DNA molecules/cell). Virtual mt number/cell ranged from 83 ± 17 to 677 ± 80 (SE) mt/cell in various cell types. All five mammalian virtual mitochondria contained the same genomic mass. The number of virtual mitochondria per cell and amount of mt DNA per cell appear to be closely regulated within a given cell type but differ widely from cell type to cell type.
A new double-electrode process of gas metal arc welding

In the USA, gas-shielded consumable electrode arc welding is the most widely used welding process. The method is referred to as metal inert gas and metal active gas and in some cases as gas metal arc (GMA). The official name of the technology is GMA welding (GMAW). Welding with a non-consumable electrode is referred to as tungsten inert gas, the official name is gas tungsten arc welding (GTAW). The well-known advantage of GMAW in comparison with GTAW is the considerably higher productivity. The need for increasing the current in this case imposes certain restrictions because in addition to increasing the melting rate of the electrode wire, there is also an increase in the heat input into the parent metal which is useful only up to a certain limit. Another factor, associated with the increase in the current, is arc pressure: parc 1⁄4 m0IJ 4p ; ð1Þ
A new translational regulator with homology to eukaryotic translation initiation factor 4G

Translation initiation in eukaryotes is facilitated by the cap structure, m7GpppN (where N is any nucleotide). Eukaryotic translation initiation factor 4F (eIF4F) is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. eIF4G interacts directly with eIF4E and eIF4A. The binding site of eIF4E resides in the N‐terminal third of eIF4G, while eIF4A and eIF3 binding sites are present in the C‐terminal two‐thirds. Here, we describe a new eukaryotic translational regulator (hereafter called p97) which exhibits 28% identity to the C‐terminal two‐thirds of eIF4G. p97 mRNA has no initiator AUG and translation starts exclusively at a GUG codon. The GUG‐initiated open reading frame (907 amino acids) has no canonical eIF4E binding site. p97 binds to eIF4A and eIF3, but not to eIF4E. Transient transfection experiments show that p97 suppresses both cap‐dependent and independent translation, while eIF4G supports both translation pathways. Furthermore, inducible expression of p97 reduces overall protein synthesis. These results suggest that p97 functions as a general repressor of translation by forming translationally inactive complexes that include eIF4A and eIF3, but exclude eIF4E.
Assessment of Relative Accuracy of AHN-2 Laser Scanning Data Using Planar Features

AHN-2 is the second part of the Actueel Hoogtebestand Nederland project, which concerns the acquisition of high-resolution altimetry data over the entire Netherlands using airborne laser scanning. The accuracy assessment of laser altimetry data usually relies on comparing corresponding tie elements, often points or lines, in the overlapping strips. This paper proposes a new approach to strip adjustment and accuracy assessment of AHN-2 data by using planar features. In the proposed approach a transformation is estimated between two overlapping strips by minimizing the distances between points in one strip and their corresponding planes in the other. The planes and the corresponding points are extracted in an automated segmentation process. The point-to-plane distances are used as observables in an estimation model, whereby the parameters of a transformation between the two strips and their associated quality measures are estimated. We demonstrate the performance of the method for the accuracy assessment of the AHN-2 dataset over Zeeland province of The Netherlands. The results show vertical offsets of up to 4 cm between the overlapping strips, and horizontal offsets ranging from 2 cm to 34 cm.
Recalage hétérogène de nuages de points 3D. Application à l'imagerie sous-marine

Le recalage de deux nuages de points 3D est une etape essentielle dans de nombreuses applications. L’objectif de notre travail est d’estimer une transformation isometrique permettant de fusionner au mieux deux ensembles heterogenes de points issus de deux capteurs differents. Dans cet article, nous presenterons une methode de recalage 3D - 3D originale qui se distingue par la nature de la signature extraite en chaque point et par le critere de similarite utilise pour mesurer le degre de ressemblance. Le descripteur que nous pr oposons est invariant a la rotation et a la translation et permet egalement de s’affranchir du probleme de la multi - resolution relatif aux donnees heterogenes. Dans le but de valider notre approche, nous l’avons teste sur des donnees synthetiques et nous l’avons applique sur des donnees reelles heterogenes.
The Block Distributed Memory Model

We introduce a computation model for developing and analyzing parallel algorithms on distributed memory machines. The model allows the design of algorithms using a single address space and does not assume any particular interconnection topology. We capture performance by incorporating a cost measure for interprocessor communication induced by remote memory accesses. The cost measure includes parameters reflecting memory latency, communication bandwidth, and spatial locality. Our model allows the initial placement of the input data and pipelined prefetching. We use our model to develop parallel algorithms for various data rearrangement problems, load balancing, sorting, FFT, and matrix multiplication. We show that most of these algorithms achieve optimal or near optimal communication complexity while simultaneously guaranteeing an optimal speed-up in computational complexity. Ongoing experimental work in testing and evaluating these algorithms has thus far shown very promising results.
Photodynamic inactivation of bacteria using polyethylenimine–chlorin(e6) conjugates: Effect of polymer molecular weight, substitution ratio of chlorin(e6) and pH

Antimicrobial photodynamic therapy (APDT) is a novel technique to treat local infections. Previously we reported that the attachment of chlorin(e6) to polyethylenimine (PEI) polymers to form PEI‐ce6 conjugates is an effective way to improve ce6 PDT activity against bacteria. The aim of this work was to explore how the polymer molecular weight, substitution ratio (SR) of ce6 and pH value affect the PDT efficacy.
Extracorporeal Immunoglobulin Elimination for the Treatment of Severe Myasthenia Gravis

Myasthenia gravis (MG) is a neuromuscular disorder leading to fluctuating muscle weakness and fatigue. Rarely, long-term stabilization is not possible through the use of thymectomy or any known drug therapy. We present our experience with extracorporeal immunoglobulin (Ig) elimination by immunoadsorption (adsorbers with human Ig antibodies). Acetylcholine receptor antibodies (AChRAs) were measured during long-term monitoring (4.7 ± 2.9 years; range 1.1–8.0). A total of 474 samples (232 pairs) were analyzed, and a drop in AChRA levels was observed (P = .025). The clinical status of patients improved and stabilized. Roughly 6.8% of patients experienced clinically irrelevant side effects. The method of Ig elimination by extracorporeal immunoadsorption (IA) is a clinical application of the recent biotechnological advances. It offers an effective and safe therapy for severe MG even when the disease is resistant to standard therapy.
CHIC - a pluggable solution for community help in context

Online "Helps" must capture the problem of decontextualisation. In the literature the following three methods are presented to bridge the gap between the user's problem situation and the provided help: using methods of the information retrieval, computer mediated communication and techniques of context awareness.Focusing on professional help only is a drawback most help systems research have today. In order to overcome these shortcomings, this paper presents how the different help methods can be combined with the concepts of community based help systems by using Wikis. We will argue that the next big step is to integrate Wikis into the applications so that there is a more seamless transition between the use context and using the Wiki as a Help System.In order to prove our concept, we designed a CHiC (Community Help in Context) prototype based on Eclipse, and use it in a rich client for a Groupware-System.
Detecting deadlock in programs with data-centric synchronization

Previously, we developed a data-centric approach to concurrency control in which programmers specify synchronization constraints declaratively, by grouping shared locations into atomic sets. We implemented our ideas in a Java extension called AJ, using Java locks to implement synchronization. We proved that atomicity violations are prevented by construction, and demonstrated that realistic Java programs can be refactored into AJ without significant loss of performance. This paper presents an algorithm for detecting possible deadlock in AJ programs by ordering the locks associated with atomic sets. In our approach, a type-based static analysis is extended to handle recursive data structures by considering programmer-supplied, compiler-verified lock ordering annotations. In an evaluation of the algorithm, all 10 AJ programs under consideration were shown to be deadlock-free. One program needed 4 ordering annotations and 2 others required minor refactorings. For the remaining 7 programs, no programmer intervention of any kind was required.
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

Significance Recently it has been suggested that metformin, the most commonly used antidiabetic drug, might also possess general health-promoting properties. Elucidating metformin’s mode of action will vastly increase its application range and will contribute to healthy aging. We reveal a signaling cascade in which metformin is able to extend lifespan by increasing the production of reactive oxygen species (ROS). This allowed us to further work at the crossroads of human disease and aging research, identifying a key molecule that is able to translate the ROS signal into a prolongevity cue: an antioxidant peroxiredoxin is also able to activate a lifespan-promoting signaling cascade, here described in detail. Continued research efforts in this field lead toward a targeted improvement of aging-related complications. The antiglycemic drug metformin, widely prescribed as first-line treatment of type II diabetes mellitus, has lifespan-extending properties. Precisely how this is achieved remains unclear. Via a quantitative proteomics approach using the model organism Caenorhabditis elegans, we gained molecular understanding of the physiological changes elicited by metformin exposure, including changes in branched-chain amino acid catabolism and cuticle maintenance. We show that metformin extends lifespan through the process of mitohormesis and propose a signaling cascade in which metformin-induced production of reactive oxygen species increases overall life expectancy. We further address an important issue in aging research, wherein so far, the key molecular link that translates the reactive oxygen species signal into a prolongevity cue remained elusive. We show that this beneficial signal of the mitohormetic pathway is propagated by the peroxiredoxin PRDX-2. Because of its evolutionary conservation, peroxiredoxin signaling might underlie a general principle of prolongevity signaling.
Compact CMOS current conveyor for integrated NEMS resonators

A fully integrated nanoelectromechanical system (NEMS) resonator together with a compact built-in complementary metal-oxide-semiconductor (CMOS) interfacing circuitry is presented. The proposed low-power second generation current conveyor circuit allows measuring the mechanical frequency response of the nanocantilever structure in the megahertz range. Detailed experimental results at different DC biasing conditions and pressure levels are presented for a real mixed electromechanical system integrated through a combination of in-house standard CMOS technology and nanodevice post-processing based on nanostencil lithography. The proposed readout circuit can be adapted to operate the nanocantilever in closed loop as a stand-alone oscillator.
Structural Recovery of High-Aspect-Ratio Nanoparticle/Polymer Nanocomposites in Simple Shear Flow

Structure formation, break-down, orientation, and recovery in a multiwalled carbon nanotube (MWCNT)-polyethylene oxide nanocomposite above the percolation threshold were investigated using oscillatory and rotational rheometric studies. It was found that above the percolation threshold a percolating cluster is formed in the mixture, which is broken down upon application of a shearing force greater than a critical value. The critical value depends on both temperature and concentration of MWCNT particles in the polymer matrix. No full recovery of the structure was observed, even after 3600 s of rest time. This was attributed to a very high tendency of the MWCNT particles to reaggregate and the high strength of the primary percolating cluster formed during the recovery process. A generalized mechanism was proposed for the breakdown and recovery of the clusters of the MWCNT particles which can explain the observations for different kinds of matrices and dispersed particles.
Myosin VI facilitates connexin 43 gap junction accretion

ABSTRACT In this study, we demonstrate myosin VI enrichment at Cx43 (also known as GJA1)-containing gap junctions (GJs) in heart tissue, primary cardiomyocytes and cell culture models. In primary cardiac tissue and in fibroblasts from the myosin VI-null mouse as well as in tissue culture cells transfected with siRNA against myosin VI, we observe reduced GJ plaque size with a concomitant reduction in intercellular communication, as shown by fluorescence recovery after photobleaching (FRAP) and a new method of selective calcein administration. Analysis of the molecular role of myosin VI in Cx43 trafficking indicates that myosin VI is dispensable for the delivery of Cx43 to the cell surface and connexon movement in the plasma membrane. Furthermore, we cannot corroborate clathrin or Dab2 localization at gap junctions and we do not observe a function for the myosin-VI–Dab2 complex in clathrin-dependent endocytosis of annular gap junctions. Instead, we found that myosin VI was localized at the edge of Cx43 plaques by using total internal reflection fluorescence (TIRF) microscopy and use FRAP to identify a plaque accretion defect as the primary manifestation of myosin VI loss in Cx43 homeostasis. A fuller understanding of this derangement may explain the cardiomyopathy or gliosis associated with the loss of myosin VI. Highlighted Article: Myosin VI localizes to gap junctions in a variety of cell types and tissues, where this motor regulates gap junction plaque size through interaction with cortical actin.
Approximating geometrical graphs via “spanners” and “banyans”

probability l/2 in a Monte Carlo sense2 in time The main result of t,his paper is an improvement of Arora’s method to find (l+e) approximations for geometric NP-hard problems including the Euclidean Traveling Salesman Problem and t.he Euclidean Steiner Minimum Tree problems. For f&d dimension d and E, our algorithms run in O(NlogN) time. (s\/;i) O(d(+.&)d-‘) N + O(dN log N)
Combining Grid Mapping with local map descriptor for fast succinct map retrieval

Map retrieval, the problem of similarity search among a large collection of 2D pointset maps previously built by mobile robots, is crucial for autonomous navigation in both indoor and outdoor environments. Unlike previous Bag-of-words scene model which lacks spatial layout information, we exploit a holistic local map descriptor which is view-independent and highly discriminative. The current study is inspired by our recent papers on “local map descriptor”, in which the viewpoint or the origin of local map coordinate is planned by scene parsing and the spatial layout of a local map is represented with respect to the planned viewpoint. The main contribution of this study is to build on the framework of local map descriptor and experimentally evaluate the effectiveness of the proposed method. The key observation is that accuracy of the spatial layout should be improved by introducing an accurate local mapping technique. To this end, we implemented the state-of-the-art particle filter-based mapping algorithm of Grid Mapping. The next contribution is that we conducted map retrieval experiments using a real mobile robot in feature-less office-like environments. We experimentally demonstrate the effectiveness of the proposed approach.
Proactive 3D scanning of inaccessible parts

The evolution of 3D scanning technologies have revolutionized the way real-world object are digitally acquired. Nowadays, high-definition and high-speed scanners can capture even large scale scenes with very high accuracy. Nevertheless, the acquisition of complete 3D objects remains a bottleneck, requiring to carefully sample the whole object's surface, similar to a coverage process. Holes and undersampled regions are common in 3D scans of complex-shaped objects with self occlusions and hidden interiors. In this paper we introduce the novel paradigm of proactive scanning, in which the user actively modifies the scene while scanning it, in order to reveal and access occluded regions. We take a holistic approach and integrate the user interaction into the continuous scanning process. Our algorithm allows for dynamic modifications of the scene as part of a global 3D scanning process. We utilize a scan registration algorithm to compute motion trajectories and separate between user modifications and other motions such as (hand-held) camera movements and small deformations. Thus, we reconstruct together the static parts into a complete unified 3D model. We evaluate our technique by scanning and reconstructing 3D objects and scenes consisting of inaccessible regions such as interiors, entangled plants and clutter.