Miracle-dz/UniFAR-FTUs huggingface dataset:
Methods of Interfacing Rotating Machine Models in Transient Simulation Programs

The electromagnetic transient programs (EMTP-like tools) are based on the nodal (or modified nodal) equations that enable an efficient numerical solution and, subsequently, fast time-domain simulations. The state-variable-based simulation programs, such as Simulink, are also used for studying the dynamics of electrical systems. Both the offline and real-time versions of these two types of simulation tools are widely used by the researchers and engineers in industry and academia to study the transient phenomena and dynamics in power systems with rotating electrical machines. This paper provides a summary of the interfacing techniques that are utilized to integrate the general-purpose models of electrical machines with the rest of the power system network for these studies. The interfacing methods are broadly classified as indirect and direct approaches. The paper also describes the numerical properties as well as limitations imposed by the interfacing of the commonly used machine models that should be considered when selecting the simulation parameters and assessing the final results.
Tokenization based service model for cloud computing environment

All business firms have a huge number of sensitive data that required specific security. Data related to personal information, account related information, debit card details, credit card details, health data in electronic form etc. Firms and business houses generally prefer to store these data on cloud environment as cloud environment delivers huge paybacks like reduced cost and simplicity to access business data in an easy way. The huge constraint involve with sensitive data as well as its protection. So it incurs difficulty and high investment for the business group. Banking institutions and financial companies, healthcare industry, retail player and government sector strictly pursue appropriate instruction and guidelines when managing security and sensitivity of business data in cloud environment that comprise personal data, data for decision support, account related data and health related data. Tokenization based service model replaces business organization sensitive and confidential data with unique identification pattern to build it secure to steal the confidential and sensitive data, so that it fulfill the requirement given by the appropriate authority. In this work we have presented the cloud environment related tokenization based service model to protect sensitive and confidential data at lesser cost and high performance.
Determining agricultural impact on environment

As part of Serbia’s strategic goal of accession to the European Union (EU), harmonization with the agro-environmental policy is an important issue for the creators of Serbia’s agricultural and rural policy. The main goal of this study was to define a model of agro-environmental performance in Serbia and the countries of the EU to determine Serbia’s position in relation to other countries (EU-28). In this article, factor analysis was applied, with four factors extracted within the model: the degree of agricultural modernization that indirectly affects the environment, the degree of intensification of agricultural production with a direct effect on the environment, air pollution from agriculture, and energy use. The factor scores were used as variables within the Preference Ranking Organization Method for Enrichment Evaluation method to rank countries according to the impact of agriculture on the environment.
Amplatzer left atrial appendage occlusion through a patent foramen ovale

To assess feasibility and outcomes of left atrial appendage (LAA) closure when using a patent foramen ovale (PFO) for left atrial access. Background: Because of the fear of entering the left atrium too high, using a PFO for left atrial access during LAA occlusion (LAAO) is generally discouraged. We report our single‐center experience using a concomitant PFO for LAAO, thereby avoiding transseptal puncture.
Understanding relationships among ecosystem services across spatial scales and over time

Sustaining ecosystem services (ES), mitigating their tradeoffs and avoiding unfavorable future trajectories are pressing social-environmental challenges that require enhanced understanding of their relationships across scales. Current knowledge of ES relationships is often constrained to one spatial scale or one snapshot in time. In this research, we integrated biophysical modeling with future scenarios to examine changes in relationships among eight ES indicators from 2001–2070 across three spatial scales—grid cell, subwatershed, and watershed. We focused on the Yahara Watershed (Wisconsin) in the Midwestern United States—an exemplar for many urbanizing agricultural landscapes. Relationships among ES indicators changed over time; some relationships exhibited high interannual variations (e.g. drainage vs. food production, nitrate leaching vs. net ecosystem exchange) and even reversed signs over time (e.g. perennial grass production vs. phosphorus yield). Robust patterns were detected for relationships among some regulating services (e.g. soil retention vs. water quality) across three spatial scales, but other relationships lacked simple scaling rules. This was especially true for relationships of food production vs. water quality, and drainage vs. number of days with runoff >10 mm, which differed substantially across spatial scales. Our results also showed that local tradeoffs between food production and water quality do not necessarily scale up, so reducing local tradeoffs may be insufficient to mitigate such tradeoffs at the watershed scale. We further synthesized these cross-scale patterns into a typology of factors that could drive changes in ES relationships across scales: (1) effects of biophysical connections, (2) effects of dominant drivers, (3) combined effects of biophysical linkages and dominant drivers, and (4) artificial scale effects, and concluded with management implications. Our study highlights the importance of taking a dynamic perspective and accounting for spatial scales in monitoring and management to sustain future ES.
Association Between Polymorphisms in GRIK2 Gene and Obsessive‐Compulsive Disorder: A Family‐Based Study

Several studies support a genetic influence on obsessive‐compulsive disorder (OCD) etiology. The role of glutamate as an important neurotransmitter affecting OCD pathophysiology has been supported by neuroimaging, animal model, medication, and initial candidate gene studies. Genes involved in glutamatergic pathways, such as the glutamate receptor, ionotropic, kainate 2 (GRIK2), have been associated with OCD in previous studies. This study examines GRIK2 as a candidate gene for OCD susceptibility in a family‐based approach. Probands had full DSM‐IV diagnostic criteria for OCD. Forty‐seven OCD probands and their parents were recruited from tertiary care OCD specialty clinics from France and USA. Genotypes of single nucleotide polymorphism (SNP) markers and related haplotypes were analyzed using Haploview and FBAT software. The polymorphism at rs1556995 (P= 0.0027; permuted P‐value = 0.03) was significantly associated with the presence of OCD. Also, the two marker haplotype rs1556995/rs1417182, was significantly associated with OCD (P= 0.0019, permuted P‐value = 0.01). This study supports previously reported findings of association between proximal GRIK2 SNPs and OCD in a comprehensive evaluation of the gene. Further study with independent samples and larger sample sizes is required.
Prospective fate map of the mouse primitive streak at 7.5 days of gestation

Fluorescent dyes were used in the present study to map three rostrocaudal levels of the primitive streak of mouse embryos at 7.5 days of gestation. Injections at the most rostral level, the 1/4 streak level, principally labeled cells of the paraxial mesoderm, including mesenchyme in the head, and somites and segmental plate mesoderm in the trunk. Injections at the intermediate level, the 1/2 streak level, principally labeled cells of the lateral plate mesoderm of the trunk. Injections at the most caudal level, the 3/4 streak level, principally labeled cells of the extraembryonic mesoderm at the periphery (i.e., caudolateral portion) of the embryo adjacent to the developing amnion, yolk sac, and allantois. However, injections placed at all three primitive‐streak levels provided some labeled cells to the areas of the ingressed mesoderm derived from immediately adjacent levels, suggesting that prospective mesodermal areas are not fully spatially segregated from one another at this stage. These data combined with those from a companion study in which the structure of the node was defined and its derivatives were mapped (Sulik et al. [1994] Dev. Dyn. 201:260—278) allowed us to construct a prospective fate map of the mouse primitive streak at 7.5 days of gestation. This map revealed that mediolateral subdivisions of the ingressed mesoderm were arrayed in rostrocaudal sequence within the primitive streak, such that more rostral levels of the streak contained prospective medial cells (e.g., notochord and paraxial mesoderm), intermediate levels contained prospective intermediate cells (e.g., intermediate mesoderm or nephrotome and lateral plate mesoderm), and more caudal levels contained prospective lateromost cells (e.g., extraembryonic mesoderm). Prospective mesodermal cells, with the exception of those of the notochord, ingressed bilaterally from the primitive streak, contributing to the mesoderm on both the right and left sides of the axis. Our prospective fate map of the mouse primitive streak at 7.5 days of gestation, when compared to a map of the avian primitive streak at a comparable stage of development (Schoenwolf et al. [1992] Dev. Dyn. 193:235—248), demonstrates that considerable congruity exists between the locations of mesoderm precursor cells in birds and mammals. Thus, similar morphogenetic movements underlie mesoderm formation during avian and mammalian gastrulation. Moreover, prospective mesodermal locations within the mouse primitive streak correspond to recently described patterns of early gene expression (Sasaki and Hogan [1993] Development 118:47—59; Takada et al. [1994] Genes Dev. 8:174—189; Rossant, personal communication). © 1994 Wiley‐Liss, Inc.
Intracellular Fas ligand expression causes Fas-mediated apoptosis in human prostate cancer cells resistant to monoclonal antibody-induced apoptosis.

Several laboratories have attempted with little success to induce Fas-mediated apoptosis in prostate cancer (PCa) cells, using different external Fas agonists, i.e., anti-Fas antibodies and membrane-bound FasL. The present study confirms these earlier results using the anti-Fas antibody CH-11 in five human PCa cell lines (PPC-1, LNCaP, PC-3, TSU-Pr1, and DU145). However, intracellular murine FasL expression induced Fas-mediated apoptosis in all CH-11-resistant cell lines. Adenovirus (AdGFPFasL(TET)) was used to deliver a Murine FasL-GFP fusion gene into human PCa cells resulting in 70-98% apoptosis at 48 h as determined by the MTS assay. DU145 and PPC-1 cells treated with AdGFPFasL(TET) stained positive for the TUNEL assay, indicating that cell death was via apoptosis. Using immunofluorescent microscopy, Fas and GFPFasL colocalized to the same intracellular compartment. The anti-Fas neutralizing antibody ZB-4 was unable to block AdGFPFasL(TET)-mediated cell death, suggesting that intracellular FasL may ligate Fas within the Golgi and/or endoplasmic reticulum. This is the first evidence suggesting that these two molecules interact prior to cell surface presentation. Collectively, these findings indicate that intracellular GFPFasL expression is superior to CH-11 at inducing Fas-mediated apoptosis in human PCa cells and may allow use of AdGFPFasL(TET) for PCa gene therapy.
Combining N-gram retrieval with weights propagation on massive RDF graphs

N-gram approach takes the position information into account additionally and thus can offer higher accuracy in query answering than keyword based approaches and is widely used in IR and NLP. However, in large-scale RDF graphs, URIs instead of documents are the ranking and querying units; URIs are usually much shorter than documents, and different URIs are interlinked into a massive network. One shot n-gram querying is usually not good for the RDF data in many cases. In this paper, we present a hybrid framework which combines the n-gram retrieval with link analysis based weight propagation. The idea is to exploit the link structures in the RDF data graphs and propagate the one shot n-gram score weights along with these links. Large scale experiments using MapReduce on Billion Triples Challenge dataset show the hybrid framework achieves an 80.3% improvement in relevance scores over mere n-gram retrieval.
The Demography of Enterprises and Employment in the European Union Countries

The aim of this contribution is to establish a typology of European entrepreneurship countries with respect to variables related to entrepreneurial activity and economic development. Using a combined use of multidimensional data analyses allows to extend the concept of “entrepreneurial regimes” proposed by Audretsch and Fritsch (2002) and leads to distinguish five entrepreneurial regimes. Moreover, in order to better characterize classes, a wide set of illustrative variables representative of national economic development, labour market functioning, formal and unformal institutional environment as well as variables specific to the entrepreneurial population are considered. Finally, discriminant analyzes show that the five explanatory themes that are considered (Innovation, Employment, Formal Institutions, Entrepreneurship and Governance) differentiate the classes and significantly explain the diversity of entrepreneurial regimes. These findings have important implications for the implementation of public policy in order to promote entrepreneurial activity and reduce unemployment.
The Power of Movement: Body-Engaging Activities for Teaching Economics.

Existing research points to the critical connection between student engagement and deep learning. This paper explores body engagement as one type of studentcentered learning. While other disciplines are making progress in developing body-engaging pedagogical methods as a complement to traditional lectures, the use of such innovations in undergraduate level economics courses have been limited. We contribute to the literature by explaining both why we should and how we can incorporate body movement as a part of the tool kit for teaching economics. We offer specific examples of body-engaging activities and review students’ evaluation of this pedagogical approach. We acknowledge challenges and limitations of incorporating these activities into a classroom and offer strategies to overcome these challenges.
Supporting delivery of adaptive hypermedia

Although Adaptive Hypermedia (AH) can improve upon the traditional one-size-fitsall learning approach through Adaptive Educational Hypermedia (AEH), it still has problems with the authoring and delivery processes that are holding back the widespread usage of AEH. In this thesis we present the development of the Adaptive Delivery Environment (ADE) delivery system and use the lessons learnt during its development along with feedback from adaptation specification authors, researchers and other evaluations to formalise a list of essential and recommended optional features for AEH delivery engines. In addition to this we also investigate how the powerful adaptation techniques recommended in the above list and described in Brusilovsky and Knutov’s taxonomies can be implemented in a way that minimises the technical knowledge of adaptation authors needed to use these techniques. As the adaptation functionality increases, we research how a modular framework for adaptation strategies can be created to increase the reusability of parts of an AH system’s overall adaptation specification. Following on from this, we investigate how reusing these modular strategies via a pedagogically based visual editor can enable adaptation authors without programming experience to use these powerful adaptation techniques.
The future of prodrugs – design by quantum mechanics methods

Introduction: The revolution in computational chemistry greatly impacted the drug design and delivery fields, in general, and recently the utilization of the prodrug approach in particular. The use of ab initio, semiempirical and molecular mechanics methods to understand organic reaction mechanisms of certain processes, especially intramolecular reactions, has opened the door to design and to rapidly produce safe and efficacious delivery of a wide range of active small molecule and biotherapeutics such as prodrugs. Areas covered: This article provides the readers with a concise overview of this modern approach to prodrug design. The use of computational approaches, such as density functional theory (DFT), semiempirical and ab initio molecular orbital methods, in modern prodrugs design will be discussed. The novel prodrug approach to be reported in this review implies prodrug design based on enzyme model (mimicking enzyme catalysis) that has been utilized to understand how enzymes work. The tool used in the design is a computational approach consisting of calculations using molecular orbital and molecular mechanics methods (DFT, ab initio and MM2) and correlations between experimental and calculated values of intramolecular processes that were used to understand the mechanism by which enzymes might exert their high rates catalysis. Expert opinion: The future of prodrug technology is exciting yet extremely challenging. Advances must be made in understanding the chemistry of many organic reactions that can be effectively utilized to enable the development of even more types of prodrugs. Despite the increase in the number of marketed prodrugs, we have only started to appreciate the potential of the prodrug approach in modern drug development, and the coming years will witness many novel prodrug innovations
Novel stabilisation of emulsions by soft particles: polyelectrolyte complexes.

We put forward the concept of a novel particle stabiliser of oil-water emulsions, being the polyelectrolyte complex (PEC) formed between oppositely charged water-soluble polymers in cases where either polymer alone is incapable of stabilising an emulsion. Using poly(4-styrene sulfonate) sodium salt, PSSNa and poly(diallyldimethylammonium chloride), PDADMAC, of low polydispersity and similar molecular mass, we correlate the behaviour of their mixtures in water with that of emulsions after addition of oil. In aqueous mixtures, spherical particles of diameters between 100 and 150 nm are formed through electrostatic interactions between charged polymer chains. Around equal mole fractions of the two polymers, the zeta potential of the particles reverses in sign and emulsions of oil-in-water (o/w) for a range of oils can be prepared which are the most stable to coalescence and creaming. The effects of PEC concentration and the oil : water ratio have been examined. All emulsions are o/w and stability is achieved by close-packed particle layers at drop interfaces and particle aggregation in the continuous phase. Increasing the salt concentration initially causes destabilisation of the aqueous particle dispersion due to particle aggregation followed by dissolution of particles at high concentrations; the corresponding emulsions change from being stable to completely unstable and are then re-stabilised due to adsorption of uncharged individual polymer molecules.
The Decent Society Index Mark 2: (1) Constructing the Index

In The Decent Society: planning for social quality (Abbott et al 2016) we developed the ‘Decent Society Model’ (DSM), on the shoulders of the ‘Social Quality’ approach (Beck et al 1997, 2001; Van der Maesen and Walker 2012) as a way of understanding, measuring and advising about the extent to which governments provide the resources and institutions within which their residents can live decent and productive lives. ‘Decency’ is not seen as some sort of latent variable underlying a range of indicators, but as a portmanteau term for characteristics which a society must have as ‘infrastructure’ for decent living. People have, acquire, display, profit from and develop or actualise themselves through ‘capabilities’ (see Sen 1993, 1999, 2004a,b, 2009). It is the business of the state to provide the means of acquiring developing and displaying capabilities, either directly as in the Scandinavian model of welfare or through some combination of how socioeconomic life is governed and what ‘safety-net’ provision is there for those who do not flourish. A ‘Decent Society Index’ (DSI) was constructed to explore the book’s ideas by comparing countries with which we were familiar – mostly Europe, the former Soviet Union, North America and sub-Saharan Africa. The fit of the indicators to the underlying theoretical concepts of the DSM could be improved, however, and we are now in the process of constructing a Mark 2 version which will be better conceived, and we shall try to construct ‘back data’ as well to permit the examination of trends. This first Working Paper outlines the principles and mechanisms to be used in the construction of the Index, with rationales for the decisions which are taken, and we will keep it up to date as a guide to the use of the Index by adding an Appendix giving precise origin of the data for each quadrant of the model as it is completed. Successive Working Papers will present illustrative analyses of each of the four quadrants of the Model and its corresponding Index as well as listing scores for as many of the world’s countries as we can retain despite the occasional absence of data in our main sources.
Differential effects of myosin light chain kinase inhibition on contractility, force development and myosin light chain 20 phosphorylation of rat cervical and thoracic duct lymphatics

Non‐Technical Summary The contractile activities of lymphatic muscle cells, which are the key for the lymphatic function, vary between lymphatic beds. We show that pressure‐dependent changes and myosin light chain kinase (MLCK) inhibition differentially affect myosin light chain 20 (MLC20) phosphorylation in lymphatic muscle, thereby controlling the contractile behaviour of thoracic duct and cervical lymphatics. Our findings suggest that pressure‐induced changes in lymphatic contractile function act through MLC20 di‐phosphorylation to modulate lymphatic tonic contractions, whereas the MLCK inhibitor ML‐7 affects both mono‐ and di‐phosphorylation of MLC20 and consequently decreases tonic contractions. In addition, our data indicate that ML‐7 affects pacemaking activity of lymphatic muscle, and thereby decreases the lymphatic phasic contraction frequency. Thus the statuses of MLC20 phosphorylation play essential roles in regulating the contractile activities of lymphatics.