Miracle-dz/UniFAR-FTUs huggingface dataset:
A robust mechanism for resource allocation with interference mitigation in femtocellular networks

Interference mitigation can be particularly challenging in hybrid 4G cellular networks employing a femtocellular tier, especially given the ad hoc nature in which femtocells are deployed. So far, mitigation mechanisms have been based on simplified models assuming regular (grid-based) deployment, using average interference characterization or satisfying the SINR requirements while ignoring the required data rates. In this paper, we show that such simplifications can be relaxed. Specifically, we derive an interference mitigation mechanism assuming an ad hoc deployment. The mechanism optimizes resource allocations on per-subcarrier basis while satisfying user data rate requirements. It is also based on a rigorous cross-tier interference characterization (macro-femto, femto-femto), and utilizes robust stochastic programming techniques. Simulation results indicate great potential in our proposal as it significantly outperforms a heuristic greedy algorithm.
Recommending research articles using citation data

Purpose – The purpose of this paper is to present an empirical comparison between the recommendations generated by a citation-based recommender for research articles in a digital library with those produced by a user-based recommender (ExLibris “bX”). Design/methodology/approach – For these computer experiments 9,453 articles were randomly selected from among 6.6 M articles in a digital library as starting points for generating recommendations. The same seed articles were used to generate recommendations in both recommender systems and the resulting recommendations were compared according to the “semantic distance” between the seed articles and the recommended ones, the coverage of the recommendations and the spread in publication dates between the seed and the resulting recommendations. Findings – Out of the 9,453 test runs, the recommendation coverage was 30 per cent for the user-based recommender vs 24 per cent for the citation-based one. Only 12 per cent of seed articles produced recommendations with .
Nocturnal gastric acidity and acid breakthrough on different regimens of omeprazole 40 mg daily

On chronic intake of omeprazole, most healthy volunteers and patients still have nocturnal acid breakthrough (NAB), defined as night‐time periods with gastric pH < 4.0 lasting for longer than 1 h. Gastro‐oesophageal reflux during NAB may be particularly injurious to the oesophageal mucosa, contributing to the chronic lesions complicating the condition.
Introduction to Information Extraction

In recent years, analysts have been confronted with the increasing availability of ondline sources of information in the form of naturaldlanguage texts. This increased accessibility of textual information has led to a corresponding interest in technology for processing this text automatically to extract taskdrelevant information. This demand for a technological solution to the need to deal with the oftendoverwhelming quantity of available information has stimulated the development of the field of Information Extraction. This article provides an overview of the problems addressed, current approaches toward solutions, and assesses the state of the art and its potential for future progress.
Moving beyond mass: the unmet need to consider dose metrics in environmental nanotoxicology studies.

knowledge of the particle size, shape, and crystallinity, which were reported in 60%, 48%, and 20% of the manuscripts, respectively. Only 8% of the studies reported that characterization was performed in the experimental media used to measure a toxicological response and none reported the fraction of dissolved ions present. Focused efforts to relate dosimetry to biological effects are required to better understand the ecotoxicological profiles of engineered nanomaterials and to allow risk assessors to more reliably relate exposure to effect. We challenge the research community to better address the dosimetry issue in future toxicological studies with engineered nanomaterials, and to report characterization information sufficient to convert mass
Postoperative adjuvant external‐beam radiotherapy in surgical stage I endometrial carcinoma

A combined surgical and radiotherapeutic approach is widely used in Stage I endometrial adenocarcinoma. The technique and timing of the radiotherapy varies from center to center. Postoperative external‐beam (EB) radiotherapy has the advantage of patient selection based upon surgical findings, comprehensive treatment of the pelvic nodal and vaginal cuff areas, and elimination of the need for an intracavitary procedure. Although frequently utilized, this technique is surprisingly poorly described in the medical literature. From 1979 to 1986, 46 surgical Stage I patients received adjuvant postoperative EB therapy at Georgetown University Hospital (GUH) (Washington, DC). Indications for treatment were Grade ≥2 and/or depth of myometrial invasion of >33%. The 5‐year actuarial survival was 90% with a disease‐free survival of 82%. The failure rate within the irradiated field was 6.5% with a distant failure rate of 8.7%. The rate of significant long‐term complications was acceptable at 6.5%. The authors conclude that postoperative EB radiotherapy is an effective adjuvant therapy with results comparable to other available radiotherapeutic techniques.
Dual-band bandpass filter designed by exploiting the second-order degenerated modes of the SIW-cavity

This paper presents a novel technique to design a dual-band bandpass filter by exploiting the second order degenerated modes of the SIW-cavity. The second order filter has been designed by using the proposed technique, at Ka-band of microwave frequencies; the ratio of two bands center frequencies - frequency ratio (FR) - is 1.073. Rogers RT/Duroid 5880 - with substrate height of 0.508mm - has been used as the substrate material for design purpose. The measured return loss of the filter in both bands is better than -15 dB, moreover, the isolation between two bands is also better than 40 dB.
Relations between Subjective Evaluations of Memory and Objective Memory Performance

Several explanations for the weak relations between subjective memory judgments and objective memory performance were investigated in two groups of normal older adults. Group 1 sampled a general population (mean age 61.6 yr., range 46–89), while Group 2 sampled subjects who were on a waiting list for memory training (mean age 63.0 yr., range 45–85 years). In both groups, subjective memory judgments were assessed with global ratings of memory capacity and with ratings of frequency of forgetting in specific memory situations. Memory performance was assessed with several well-known tests and with recently developed tests for domain-specific aspects of memory. Most tests concerned episodic memory. Study 1 also included measures of semantic, incidental, and working memory. Study 2 further examined the influence of the domain-specificity of objective and subjective measures for remembering names, intentions, and texts. Relations between memory self-reports and performance were weak in both groups and for all kinds of tests. Against expectations, the low correlations could not be explained by differences between ecological and laboratory tests or incidentally and intentionally remembered information, or by differences between specific failures compared to global, stereotyped judgments. Surprisingly, correlations did not increase when subjective and objective measures assessed the same ability, like remembering names. Also noncognitive variables (mood and lifestyle) did not influence the relations. The (weak) relations between subjective and objective memory measures were comparable for subjects over and under 65 years of age. Furthermore, relations were comparable for the general population sample and the memory compliant group.
Microstrip Hairpin Bandpass Filter Using Modified Minkowski Fractal-Shape for Suppression of Second Harmonic

In this paper, a novel microstrip hairpin-line bandpass filter which employs a modified Minkowski fractal shape is proposed. Although conventional hairpin-line filters are popular for RF front ends, they suffer from undesired spurious responses located at the second harmonic, which causes asymmetry in the upper skirt band. By proper design, the second harmonic of fractal filters can be significantly suppressed through the use of fractal shape. To validate this novel geometry, the proposed filters are fabricated and measured. Simulated results are in good agreement with measured results.
DEFINING BIOLOGICAL FEEDBACK CONTROL SYSTEMS *

Introduct ion HOW do biological control systems differ from conventional control systems? At first glance a biological control system looks very much like its electromechanical counterpart, and the engineer is likely to consider i t as merely a “flesh and blood variation. ” Thus the analogy is quickly seen between the pupil servomechanism and the photocell-controlled lens-opening control of an automatic movie camera, since both act to change the size of an opening, and thereby regulate the intensity of light hitting a sensitive surface. The two control systems appear similar when viewed in block diagram form because investigations of biological control systems borrow heavily from the highly developed techniques of feedback-control systems analysis. In the typical research involving a biological servomechanism, the system’s input-output characteristics are studied, particularly with regard to its frequency response and transient responses to deterministic inputs. On the basis of this data, physiological information, and a fair. amount of guessing, a model is constructed to represent the system. This model may be analytical, a computer simulation, or a physical “working model. ” The assumption is that one may experiment with different inputs, systems parameters, and topographical connections of the model, and thereby learn about the true nature of the normal and pathological functioning of the original control system. This approach was used by Wiener in his construction of a phototropic mechanical “moth” to demonstrate and study parkinsonism and intention tremor. ’ Difficulties encountered by a control engineer when he first attempts to model a control system are many. Chief among them is the inherent existence of a number of characteristics of biological servomechanisms which are not generally present in mechanical counterparts, and theref ore likely to be overlooked by the engineer on his first approach. The general representation of a feedback-control system shown in FIGURE 1 includes most of the components which the control engineer seeks to identify. The system output, coming from the controlled element (or fixed process), is the variable being controlled to follow an input reference command. The error between the input command and the output is the actuating signal driving the controller, which in turn actuates the con-
“We are all there silently coping.” The hidden experiences of parents of adults with Asperger syndrome*

Abstract Background The experiences of older parents of adults with Asperger syndrome have not been explored in the research literature. Method Four families who had middle-aged offspring with Asperger syndrome were interviewed (3 mothers and 1 couple), and the interviews were analysed using interpretative phenomenological analysis (IPA). Results Six themes emerged from the analysis: (a) providers of “hidden” support, (b) role of advocate, (c) social isolation, (d) intrafamilial relationships, (e) support for parents, and (f) future concerns. Conclusions The findings of this study offer insight into the experience of parents of adult sons with Asperger syndrome. Implications for future support interventions and research are suggested.
Développement d'un modèle d'étude du vieillissement tissulaire basé sur l'utilisation de cellules souches humaines à pluripotence induite par reprogrammation cellulaire.

En dehors du cadre pathologique, la notion de temps est la base essentielle dans le processus de vieillissement de l’organisme et des systemes associes. Ces derniers vont progressivement presenter un declin de leur(s) fonction(s) ou de nombreux mecanismes complexes vont intervenir a differents niveaux. Parmi les premiers constats proposes, le vieillissement est la consequence d’un processus ineluctable, d’une succession d’agressions au niveau cellulaire qui pourraient etre reparees voire evitees, ouvrant ainsi la voie a de futures etudes qui permettront a terme de proposer une explication plus detaillee, de ce processus. Pour exemple, les travaux que nous avons menes tentent d’apporter un element de reponse afin d’etablir un lien entre senescence et vieillissement, avec pour base de generer par reprogrammation cellulaire des cellules hiPSCs a partir de cellules issues de biopsies de patients jeunes, âgees, senescentes ou proliferatives. Outre la caracterisation de leur etat pluripotent comparable a celui des cellules souches embryonnaires, nous avons egalement mis en evidence apres une differenciation specifique en fibroblastes, que les caracteristiques cellulaires de ces fibroblastes presentaient un effacement des marques du vieillissement, signe d’une plasticite cellulaire possible au cours du vieillissement vers un rajeunissement cellulaire. A present, notre second objectif est d’etendre cette etude au modele tissulaire cutane par la mise en place de strategie de differenciation dans le lignage epidermique recapitulant les etapes du developpement. Une telle etude permettra de mieux comprendre et mieux apprehender les mecanismes pathologiques associees au vieillissement, et ainsi proposer un outil qui permettra de proposer a l’avenir une medecine appropriee et concrete aux patients.
The Case of Ireland-Northern Ireland (United Kingdom) – Regions and Innovation: Collaborating Across Borders

The island of Ireland, which includes both Ireland and Northern Ireland (United Kingdom), is home to 6.4 million people and has a combined economic output of USD 205 billion. Several cross-border institutions were created in response to the 1998 Belfast/Good Friday Agreement to recreate functional economic linkages across the border. InterTradeIreland is a rare example internationally of a cross-border entity to promote trade and innovation that is co-funded by respective governments. These efforts have led to stability in funding such programmes. The differences between the public sector driven economy in Northern Ireland and the dual economy of Ireland (outward looking multinationals and the local small and medium-sized enterprise base) are a challenge for cross-border efforts. This case study is part of the project Regions and Innovation: Collaborating Across Borders. A summary of this working paper appears in a report of the same name.
Estructuras metodológicas de revisiones sistemáticas de literatura en Ingeniería de Software: un estudio de mapeo sistemático

espanolLas revisiones sistematicas de literatura se han convertido en una metodologia importante dentro de la investigacion de la ingenieria de software. Al aplicar esta metodologia los aspectos criticos estan relacionados con lograr un diseno y una ejecucion apropiada, como tambien una estrategia de busqueda efectiva. De alli la necesidad por encontrar enfoques de diseno, ejecucion y evaluacion, para extraer de manera optima la informacion desde la literatura cientifica. El objetivo principal de esta investigacion es analizar la estructura metodologica de las revisiones sistematicas de literatura, llevadas a cabo en Ingenieria de Software evidenciando la evolucion de las distintas etapas consideradas. Para esto, se realizo un estudio de mapeo sistematico utilizando las publicaciones en los ultimos 8 anos en las bases de datos Scopus y Wos. El estudio arrojo 13 revisiones que se focalizan principalmente en areas de Calidad y Desarrollo. Ademas, los resultados muestran que aunque las revisiones utilizan una metodologia similar, pocas consideran una agregacion de evidencia. Las conclusiones principales del estudio apuntan a que los investigadores prefieren realizar revisiones dentro de areas muy acotadas dentro de la Ingenieria de Software como es el caso del area de desarrollo y calidad, asi como tambien que prefieren investigaciones no tan exhaustivas como son el mapeo sistematico por sobre las revisiones sistematicas. EnglishSystematic reviews of the literature have become an important methodology within software engineering research. In applying this methodology the critical aspects are related to achieving an appropriate design and execution, as well as an effective search strategy. Hence the need to find a design, implementation and evaluation approaches to optimally extract information from the scientific literature. The main objective of this research is to analyze the methodological structure of the systematic reviews of literature carried out in Software Engineering evidencing the evolution of the different stages considered. For this, a systematic mapping study was carried out using the publications in the last 8 years in the Scopus and Wos databases. The study yielded 13 reviews focusing mainly on Quality and Development. In addition, the results show that although the reviews use a similar methodology, few consider an aggregation of evidence. The main conclusions of the study point out that researchers prefer to carry out reviews within very limited areas within the IS such as the area of development and quality, as well as preferring non-exhaustive investigations such as systematic mapping over Systematic reviews.
Evaluation of Performance Improvements After Either Resistance Training or Sprint Interval–Based Concurrent Training

Abstract Laird IV, RH, Elmer, DJ, Barberio, MD, Salom, LP, Lee, KA, and Pascoe, DD. Evaluation of performance improvements after either resistance training or sprint interval–based concurrent training. J Strength Cond Res 30(11): 3057–3065, 2016—The purpose of this investigation was to examine the effects of concurrent sprint interval and resistance training (CST) vs. resistance training (RT) on measures of strength, power, and aerobic fitness in recreationally active women. Twenty-eight women (20.3 ± 1.7 years; 63.0 ± 9.1; 51.1 ± 7.1 1 repetition maximum (1-RM) back squat (kg); V[Combining Dot Above]O2max: 35.4 ± 4.1 ml·kg−1·min−1) were recruited to complete an 11-week training program. Participants were matched-pair assigned to CST or RT cohorts after preliminary testing, which consisted of 1-RM back squats, maximal isometric squats, anaerobic power evaluations, and maximal oxygen consumption. All subjects trained 3 days per week with sprint-interval training occurring at least 4 hours after RT in the CST cohort. Both CST and RT resulted in significant improvements (p ⩽ 0.05) in the 1-RM back squat (37.5 ± 7.8; 40.0 ± 9.6 kg), maximal isometric force (55.7 ± 51.3; 53.7 ± 36.7 kg), average peak anaerobic power testing (7.4 ± 6.2; 7.6 ± 6.4%), and zero-incline treadmill velocity, resulting in maximal oxygen consumption (1.8 ± 0.6; 0.8 ± 0.6 km·h−1). Only zero-incline treadmill velocity demonstrated a group-by-time interaction with a greater improvement after CST (p < 0.01). Rate of force development was not altered in either group. Results provide no evidence of interference to the adaptive process by CST. Coaches desiring improvements in strength, power, and endurance may want to evaluate how spring and high-intensity interval training might supplement programs already in place.
Intronic U50 small‐nucleolar‐RNA (snoRNA) host gene of no protein‐coding potential is mapped at the chromosome breakpoint t(3;6)(q27;q15) of human B‐cell lymphoma

In eukaryotic cells, nucleolar processing of preribosomal RNAs (prerRNAs) is assisted by a large number of small nucleolar RNAs (snoRNAs) that function in the 2′‐O‐methylation or the pseudouridylation of rRNAs. Most snoRNAs so far characterized are encoded and processed from introns of premRNAs.
Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma

Retinoid X receptor α (RXRα) has emerged as an important nuclear receptor involved in hepatocarcinogenesis, because its ligand suppresses the development of hepatocellular carcinoma (HCC) in both experimental and clinical studies. We have demonstrated that phosphorylation of RXRα at serine 260 interferes with its function and delays its degradation in cultured human HCC, leading to enhanced cellular proliferation. Here, we show that in normal liver and in nonproliferating hepatocyte cultures, RXRα is unphosphorylated and highly ubiquitinated, rendering it sensitive to proteasome‐mediated degradation. On the other hand, phosphoserine 260 RXRα is resistant to ubiquitination and proteasome‐mediated degradation in both human HCC tissues and a human HCC cell line, HuH7. In these tissues and cells, serine 260 is phosphorylated by mitogen‐activated protein (MAP) kinase. In proliferating normal hepatocytes, similar to HCC cells, RXRα is also phosphorylated at serine 260 and resistant to ubiquitin‐mediated degradation by proteasome, but this ubiquitination of RXRα is differentially regulated between HCC cells and normal hepatocytes. In proliferating hepatocytes, 9‐cis retinoic acid (9cRA), a ligand to RXRα, suppresses MAP kinase–mediated phosphorylation and thereby enhances ubiquitination of RXRα, whereas it fails to exert these effects in HCC cells. In conclusion, switching of the ubiquitin/proteasome‐dependent degradation of RXRα by phosphorylation at serine 260 may be responsible for the aberrant growth of HCC and its suppression by retinoids.
Design and rationale of a randomized, double-blind, placebo-controlled phase III study for autologous bone marrow cell transplantation in critical limb ischemia: the BONe Marrow Outcomes Trial in Critical Limb Ischemia (BONMOT-CLI).

BACKGROUND Critical limb ischemia (CLI) is the end-stage of peripheral artery disease. Only about two thirds of patients with CLI can be revascularised, one third progresses to leg amputation with high associated morbidity and mortality. Therapeutic angiogenesis with bone marrow cells has shown promising improvement in less severe stages of peripheral ischemia. Our study evaluates the therapeutic value of bone marrow cell induced angiogenesis and arteriogenesis in severe, limb-threatening ischemia. PATIENTS AND METHODS the BONe Marrow Outcome Trial in Critical Limb Ischemia (BONMOT-CLI) is a investigator-initiated, double-blinded, 1:1 randomized, placebo-controlled multi-centre study at 4 sites in Germany. Only patients with no option for revascularisation or after failed revascularisation will be included. A total of 90 patients is to be included. One arm with 45 subjects will be treated with a concentrate of autologous bone marrow cells which will be injected at 40 sites into the ischemic limb. In the placebo arm, study subjects will undergo a sham bone marrow punction and 40 saline injections. At three months, a combined primary endpoint of major amputation or persisting critical limb ischemia (no clinical or perfusion improvement) will be evaluated. Secondary endpoints are death, changes in perfusion, quality of life, walking distance, minor amputations, wound healing, collateral density and cancer incidence. Post-study follow-up is up to two years. CONCLUSIONS The results of this first randomized placebo-controlled trial for autologous bone marrow cell therapy in CLI will clarify the value of this new therapeutic modality in a patient population with no other alternatives except major amputation.