Miracle-dz/UniFAR-FTUs huggingface dataset:
Nuclear Envelope Phosphatase 1-Regulatory Subunit 1 (Formerly TMEM188) Is the Metazoan Spo7p Ortholog and Functions in the Lipin Activation Pathway*

Background: Lipins are phosphatidic acid phosphatases. In yeast, lipin is activated by the Nem1p-Spo7p complex. There is controversy as to whether a mammalian Spo7p ortholog exists. Results: The metazoan Spo7p ortholog is now identified and shown to interact with lipins in yeast, nematodes, and mammalian cells. Conclusion: NEP1-R1 is the metazoan Spo7p ortholog. Significance: The lipin activation system is conserved in evolution. Lipin-1 catalyzes the formation of diacylglycerol from phosphatidic acid. Lipin-1 mutations cause lipodystrophy in mice and acute myopathy in humans. It is heavily phosphorylated, and the yeast ortholog Pah1p becomes membrane-associated and active upon dephosphorylation by the Nem1p-Spo7p membrane complex. A mammalian ortholog of Nem1p is the C-terminal domain nuclear envelope phosphatase 1 (CTDNEP1, formerly “dullard”), but its Spo7p-like partner is unknown, and the need for its existence is debated. Here, we identify the metazoan ortholog of Spo7p, TMEM188, renamed nuclear envelope phosphatase 1-regulatory subunit 1 (NEP1-R1). CTDNEP1 and NEP1-R1 together complement a nem1Δspo7Δ strain to block endoplasmic reticulum proliferation and restore triacylglycerol levels and lipid droplet number. The two human orthologs are in a complex in cells, and the amount of CTDNEP1 is increased in the presence of NEP1-R1. In the Caenorhabditis elegans embryo, expression of nematode CTDNEP1 and NEP1-R1, as well as lipin-1, is required for normal nuclear membrane breakdown after zygote formation. The expression pattern of NEP1-R1 and CTDNEP1 in human and mouse tissues closely mirrors that of lipin-1. CTDNEP1 can dephosphorylate lipins-1a, -1b, and -2 in human cells only in the presence of NEP1-R1. The nuclear fraction of lipin-1b is increased when CTDNEP1 and NEP1-R1 are co-expressed. Therefore, NEP1-R1 is functionally conserved from yeast to humans and functions in the lipin activation pathway.
UAlacant: Using Online Machine Translation for Cross-Lingual Textual Entailment

This paper describes a new method for cross-lingual textual entailment (CLTE) detection based on machine translation (MT). We use sub-segment translations from different MT systems available online as a source of cross-lingual knowledge. In this work we describe and evaluate different features derived from these sub-segment translations, which are used by a support vector machine classifier to detect CLTEs. We presented this system to the SemEval 2012 task 8 obtaining an accuracy up to 59.8% on the English-Spanish test set, the second best performing approach in the contest.
A Path Model for Adult Learner Feedback

A path model of adult learner feedback that combined aspects of students' conceptions of learning and motivation was developed. Students that were high on achievement motivation and in their belief of their own competence or competency expectations showed high graded performance. Students that were high on competency expectations and on mastery goals were also high on intrinsic motivation. Significant gender differences were not found on any of the variables used in this study, and adult learners' assessment of their own ability to do well agreed with their actual performance. Suggestions are made for further study that could elaborate on the proposed path model.
Stem Cells : Physiology and Microenvironment Tcf 7 l 2 localization of putative stem / progenitor cells in mouse conjunctiva

Quan Y, Zhang X, Xu S, Li K, Zhu F, Li Q, Cai X, Lu R. Tcf7l2 localization of putative stem/progenitor cells in mouse conjunctiva. Am J Physiol Cell Physiol 311: C246–C254, 2016. First published June 8, 2016; doi:10.1152/ajpcell.00014. 2016. —Conjunctival integrity and preservation is indispensable for vision. The self-renewing capacity of conjunctival cells controls conjunctival homeostasis and regeneration; however, the source of conjunctival self-renewal and the underlying mechanism is currently unclear. Here, we characterize the biochemical phenotype and proliferative potential of conjunctival epithelial cells in adult mouse by detecting proliferation-related signatures and conducting clonal analysis. Further, we show that transcription factor 7-like 2 (T-cell-specific transcription factor 4), a DNA binding protein expressed in multiple types of adult stem cells, is highly correlated with proliferative signatures in basal conjunctival epithelia. Clonal studies demonstrated that Transcription factor 7-like 2 (Tcf7l2) was coexpressed with p63 and proliferating cell nuclear antigen (PCNA) in propagative colonies. Furthermore, Tcf7l2 was actively transcribed concurrently with conjunctival epithelial proliferation in vitro. Collectively, we suggest that Tcf7l2 may be involved in maintenance of stem/progenitor cells properties of conjunctival epithelial stem/progenitor cells, and with the fornix as the optimal site to isolate highly proliferative conjunctival epithelial cells in adult mice.
Replication is not needed: single database, computationally-private information retrieval

We establish the following, quite unexpected, result: replication of data for the computational private information retrieval problem is not necessary. More specifically, based on the quadratic residuosity assumption, we present a single database, computationally private information retrieval scheme with O(n/sup /spl epsiv//) communication complexity for any /spl epsiv/>0.
Anticardiolipin, anti-β2-glycoprotein I and antiprothrombin antibodies in black South African patients with infectious disease

Objectives: To investigate IgG, IgM, and IgA, antiphospholipid antibodies (aPL), against cardiolipin (aCL), β2-glycoprotein I (anti-β2GPI), and prothrombin (anti-PT), in black South African patients with infectious disease. Unlike patients with systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS), raised levels of aPL in infectious diseases are not usually associated with thrombotic complications. Patients and methods: Serum samples from 272 patients with a variety of infectious diseases (100 HIV positive, 112 leprosy, 25 syphilis, 25 malaria, and 10 HCV patients) were studied and compared with autoantibody levels in 100 normal controls. All three aPL were measured using commercial enzyme linked immunosorbent assay (ELISA) kits. Results: Raised levels of all thee aPL were found in all patient groups studied: aCL in 7%, anti-β2GPI in 6%, and aPT in 43% of 100 HIV patients, in 29%, 89%, and 21% of 112 patients with leprosy, in 8%, 8%, and 28% of 25 patients with syphilis, in 12%, 8%, and 28% of 25 patients with malaria, and in 20%, 30%, and 30% of 10 HCV patients studied, respectively. Conclusions: The prevalence of aCL and anti-β2GPI in black South African HIV positive patients, or those with syphilis, malaria, or hepatitis C virus is lower than reported for mixed race or white populations. aPT were the most prevalent aPL detected in these patient groups, except in patients with leprosy, for whom anti-β2GPI was the most prevalent, and where the spectrum of aPL was similar to that seen in patients with SLE and APS.
enomic and biological analysis of Grapevine leafroll-associated virus 7 reveals a ossible new genus within the family Closteroviridae aher

Deep sequencing analysis of an asymptomatic grapevine revealed a virome containing five RNA viruses and a viroid. Of these, Grapevine leafroll-associated virus 7 (GLRaV-7), an unassigned closterovirus, was by far the most prominently represented sequence in the analysis. Graft-inoculation of the infection to another grape variety confirmed the lack of the leafroll disease symptoms, even though GLRaV-7 could be detected in the inoculated indicator plants. A 16,496 nucleotide-long genomic sequence of this virus was determined from the deep sequencing data. Its genome architecture and the sequences encoding
Transformational leadership and followers' attitudes: the mediating role of psychological empowerment

There is now strong evidence that transformational leadership substantially influences the work attitudes and behaviours of followers. However, the mechanisms by which transformational leaders influence their followers have not been studied in a systematic fashion. The purpose of the present study is, therefore, to analyse how transformational leadership promotes: i) job satisfaction among employees; and ii) affective commitment to the organization. In particular, the possible mediating role of psychological empowerment in these two relationships is conceptually hypothesised and empirically tested. The results demonstrate that psychological empowerment mediates the relationship between transformational leadership and employee attitudes.
An Alternative Decision-Making Procedure for Performance Assessments: Using the Multifaceted Rash Model to Generate Cut Estimates

This article describes an alternative approach to setting standards for performance assessments. The procedure was designed for use in low-budget, relatively low-stakes contexts where it is not possible to bring expert judges together. The procedure that allowed participant judges to work individually throughout the process was an effort to compensate for the lack of face-to-face interactions between judges. The viability of the proposed procedure in generating workable cut estimates was examined via its application to a certification examination in medical translation. Data were collected from a case study conducted by Kozaki (2004) and its replication, which were linked together by the Multifaceted Rasch Model into a single frame of reference. The results showed that the judges' intentions were overall well represented in the generated cut estimates and that the decision making was realistic. It is suggested that the proposed procedure should offer a viable alternative in relatively low-stakes environments to full-fledged standard-setting procedures and that thus it may be of benefit to examiners who need principled approaches to setting cut estimates for performance assessments with constrained budgets.
A daily diary study of goals and affective well-being at work

We examine whether attainment of goals at work is associated with enhanced affective well-being and whether attainment of personally more important goals has a stronger association with affective well-being. Data were collected from call-centre staff using a daily diary for 2 weeks. Results indicate that daily attainment of work goals is associated with more activated affect measured at the end of the working day. The relationship between attainment of goals and pleasurable affect is stronger where goals are personally more important.
Participatory Theater as a Science Communication Tool in Timor Leste

This article examines the trial of participatory theater for disseminating new agricultural knowledge among subsistence farmers in Timor Leste, a small underdeveloped country in the Asia-Pacific region. The aim of the trial was to provide information on improved seed varieties and appropriate agronomic practices to maximize their yield among rural communities where rates of adult illiteracy are high and the reach of mass media forms of communication is low. The findings highlight the potential for entertainment-education forms to provide effective science communication tools in contexts where approaches more typical in developed countries are severely constrained.
Golf ball detection from multi-exposure images under heavy occlusion

In this paper, we propose an automatic technique for detecting golf balls from multi-exposure images under heavy occlusion. The proposed technique consists of two processes. First, an automatic region-of-interest detection process based on image thresholding and labelling techniques is employed to separate regions of interest of golf ball from each multi-exposure image. Then, a novel adaptive ball detection and selection process based on circular Hough transform and circular shape correlation is applied to each region of interest for determining the location and radius of each golf ball with high-accuracy irrespective of occlusion. Experimental results show that the proposed technique is capable of automatic golf ball detection under heavy occlusion.
Antecedents of philanthropic behavior of health care volunteers

Purpose – This paper aims to propose a conceptual model of philanthropic behavior of volunteers in the health care sector. Design/methodology/approach – This study is based on an extensive review of past research on philanthropic behavior. To conduct the literature review, keywords such as philanthropy, philanthropic behavior, giving, donating, competencies, volunteering and social network in health care were identified. Findings – From the literature reviewed, three groups of antecedents of philanthropic behavior among health care volunteers (HCVs) were identified, viz., individual factors, social factors and organizational factors. This paper proposes social network as a mediating variable in linking the three groups of antecedents with philanthropic behavior. The paper offers a number of propositions which explain the proposed model of philanthropic behavior of HCVs. Practical implications – Further research is suggested to test and validate the framework to provide empirical evidence. Upon model valid.
A Review of Transmission Electron Microscopy of Quasicrystals—How Are Atoms Arranged?

Quasicrystals (QCs) possess rotational symmetries forbidden in the conventional crystallography and lack translational symmetries. Their atoms are arranged in an ordered but non-periodic way. Transmission electron microscopy (TEM) was the right tool to discover such exotic materials and has always been a main technique in their studies since then. It provides the morphological and crystallographic information and images of real atomic arrangements of QCs. In this review, we summarized the achievements of the study of QCs using TEM, providing intriguing structural details of QCs unveiled by TEM analyses. The main findings on the symmetry, local atomic arrangement and chemical order of QCs are illustrated.
Reward Timing in the Primary Visual Cortex

We discovered that when adult rats experience an association between visual stimuli and subsequent rewards, the responses of a substantial fraction of neurons in the primary visual cortex evolve from those that relate solely to the physical attributes of the stimuli to those that accurately predict the timing of reward. In addition to revealing a remarkable type of response plasticity in adult V1, these data demonstrate that reward-timing activity—a “higher” brain function—can occur very early in sensory-processing paths. These findings challenge the traditional interpretation of activity in the primary visual cortex.
Vertex Degree Distribution for the Graph of Word Co-Occurrences in Russian

Degree distributions for word forms cooccurrences for large Russian text collections are obtained. Two power laws fit the distributions pretty good, thus supporting Dorogovtsev-Mendes model for Russian. Few different Russian text collections were studied, and statistical errors are shown to be negligible. The model exponents for Russian are found to differ from those for English, the difference probably being due to the difference in the collections structure. On the contrary, the estimated size of the supposed kernel lexicon appeared to be almost the same for the both languages, thus supporting the idea of importance of word forms for a perceptual lexicon of a human.
Cognitive apprenticeship theory and its implications for doctoral education: a case example from a doctoral program in higher and adult education

This article argues that the theory of cognitive apprenticeship could inform those who teach and work with doctoral students in ways that enable them to provide students with more systematic preparation, more focused guidance and scaffolding, more explicit feedback, and enhanced preparation for participating in a collaborative way in communities of scholars. Using the author’s teaching experience with a first‐year doctoral seminar in a program in higher education, the article suggests five specific strategies for utilizing the theory of cognitive apprenticeship in practical and effective ways to strengthen the socialization of future scholars. Cet article défend la thèse selon laquelle la théorie du compagnonnage cognitif (cognitive apprenticeship) peut aider ceux qui enseignent et qui œuvrent auprès des doctorants de façon à fournir à ces derniers une préparation davantage systématique, un accompagnement davantage focalisé, une feed‐back plus explicite, ainsi qu’une meilleure préparation à la participation collaborative à une communauté d’universitaires. Se basant sur l’expérience d’enseignement de l’auteur dans le contexte d’un séminaire doctoral de première année, dans le cadre d’un programme portant sur l’enseignement supérieur, l’article présente cinq stratégies spécifiques à l’utilisation de la théorie du compagnonnage cognitif visant à renforcer la socialisation des universitaires de demain.
Occupational and sporting identities : knowledge, practices and performance

The work which is submitted for the degree of PhD by publication comprises eleven papers published in peer-reviewed journals: six sole-authored papers and five jointauthored. The publications span the years 1995 to the present, and the qualitative research projects from which the data and publications are derived were undertaken over a period of approximately ten years, commencing in 1994/95. The publications are included in full and are examined, both individually and within a more general context, in an overview. The overarching focus of the research coheres around the construction and maintenance of occupational and leisure identities, and more specifically in the case of the latter, on sporting identities. All the research projects from which the publications derive were qualitative in nature, apart from the earliest work on doctoral students in the social sciences, which was based predominantly on documentary analysis of the relevant literature. Whilst the unifying theme of the research and the PhD submission might be termed 'identity work', three principal strands can be delineated and these are described in some detail in the overview: 1) Occupational identities: contract researchers in the social sciences; 2) Occupational identities: doctoral research students; 3) Sporting identities: distance
Self-Perceived Effects of Pornography Consumption in a Sample of Indonesian University Students

Self-perceived effects of pornography consumption were studied in a sample of university students in Indonesia—a conservative, Muslim majority country with strict anti-pornography laws. Using a cross-sectional design and a modified version of the Pornography Consumption Effect Scale (PCES), we assessed participants' reports of how pornography affected their sexual knowledge, attitude toward sex, sex life, perception of and attitude toward the opposite gender, and life in general. The area of attitude toward sex excepted, the study found that both men and women reported significantly larger positive than negative effects. Further, as compared to women, men reported significantly larger negative effects of their pornography consumption. For both genders, pornography-related variables were found to add significantly to the prediction of both positive and negative self-perceived effects of pornography consumption over and above a number of included control variables.
AQP2 exocytosis in the renal collecting duct – involvement of SNARE isoforms and the regulatory role of Munc18b

Vasopressin regulates the fusion of the water channel aquaporin 2 (AQP2) to the apical membrane of the renal collecting-duct principal cells and several lines of evidence indicate that SNARE proteins mediate this process. In this work MCD4 renal cells were used to investigate the functional role of a set of Q- and R-SNAREs, together with that of Munc18b as a negative regulator of the formation of the SNARE complex. Both VAMP2 and VAMP3 were associated with immunoisolated AQP2 vesicles, whereas syntaxin 3 (Stx3), SNAP23 and Munc18 were associated with the apical plasma membrane. Co-immunoprecipitation experiments indicated that Stx3 forms complexes with VAMP2, VAMP3, SNAP23 and Munc18b. Protein knockdown coupled to apical surface biotinylation demonstrated that reduced levels of the R-SNAREs VAMP2 and VAMP3, and the Q-SNAREs Stx3 and SNAP23 strongly inhibited AQP2 fusion at the apical membrane. In addition, knockdown of Munc18b promoted a sevenfold increase of AQP2 fused at the plasma membrane without forskolin stimulation. Taken together these findings propose VAMP2, VAMP3, Stx3 and SNAP23 as the complementary set of SNAREs responsible for AQP2-vesicle fusion into the apical membrane, and Munc18b as a negative regulator of SNARE-complex formation in renal collecting-duct principal cells.
Adaptive depth boundary sharpening for effective view synthesis

This paper focuses on sharpening boundaries in depth maps for multi-view video coding. Artifacts around boundaries degrade the quality of synthesized images. In order to encounter this problem, after applying the deblocking filter for each frame, we create a binary edge map and find the location of blocks that need to be altered. Subsequently, we apply a boundary sharpening filter which uses pixel frequency, similarity, and closeness as sub-costs. This filter is only applied to blocks which are near edges. Experimental results exhibit much more visual comfort level in synthesized images compared to when JMVC was used.
THE STATE AND FISCAL SOCIOLOGY

Despite recent developments in “fiscal sociology” (i.e. the sociological analysis of taxation and public finances), few efforts have been made to synthesize scholarly developments in the field. This is particularly surprising because much of the literature on the determinants of taxation bears directly on the debates in political sociology about the social, political, institutional, and other determinants of government policy. This essay reviews and integrates the literature on tax policy formation and relates it to these general debates. It also explores some of the important but often neglected effects that taxation has on such phenomena as political revolution, state building, economic organization, labor force participation, and philanthropy. Thus, this essay demonstrates the significance and reviews recent developments in fiscal sociology.
Syntactic Function-Based Chinese Lexical Categories and Category Grammar Parsing

By merging syntactic categories of word classes, lexical categories were obtained. By demonstrating combination and type raising rules respectively from curried and uncurried perspectives, a category combination algorithm was presented, in which application, composition and type raising rules were sequentially examined, and the first available rule was selected. A Chinese CCG parser was developed, including Chinese word segmentation, category annotation, and syntactic parsing, which could obtain all parsing trees for given category sequence, but only determinatively chose one to print. Experiments show the parser can correctly perform categorial derivations, and lexical categories determined by syntactic function are reasonable and acceptable.