Miracle-dz/UniFAR-FTUs huggingface dataset:
Unterstützungssysteme im Kontext von Regionalisierungsprozessen. Eine theoretische und empirische Annäherung.

In Fragen der Schulentwicklung allgemein, aber auch im Zuge der aktuellen Regionalisierungstendenzen im Schul- und Bildungswesen, wird Unterstutzungssystemen fur die Einzelschule eine wachsende Bedeutung zugeschrieben. Dennoch finden sich bislang erst wenige Arbeiten im Diskurs, die Unterstutzungssysteme im Zusammenhang mit Regionalisierungsprozessen beleuchten und robuste Analyseinstrumente vorstellen, mit deren Hilfe Unterstutzung im Zusammenhang von Regionalisierung gefasst werden kann. Dieses Desiderat wird im vorliegenden Beitrag aufgegriffen, indem unter anderem auf Grundlage von governance- sowie motivationstheoretischen Uberlegungen Kategorien fur eine Heuristik erarbeitet werden, die es erlauben, Unterstutzungssysteme allgemein und im Kontext von Schul- und Bildungslandschaften entlang verschiedener Dimensionen zu betrachten. Mittels Interviews, die im Rahmen des Projektes ,Schulen im Team – Ubergange gemeinsam gestalten‘ durchgefuhrt wurden, wird die Heuristik auf den Forschungskontext zu Regionalen Bildungsburos inhaltsanalytisch angewendet. Erste Befunde weisen darauf hin, dass sich die Heuristik zur Untersuchung von Unterstutzungssystemen fur einen regionalen Kontext plausibilisieren lasst. (DIPF/Orig.) In the context of the school development discourse and of current regionalization processes in particular, support systems for schools have increasingly gained importance. At the same time, an important research gap has emerged with respect to inter-relations between support systems and regionalization processes. In fact, there is a lack of robust instruments for analyzing support structures in the regionalization context. We address this gap by developing a heuristic to examine support systems designed for educational landscapes along different dimensions. For this we use aspects of motivation and governance theories. We then apply the heuristic to interview data collected in the regional school network project ‘Schulen im Team – Ubergange gemeinsam gestalten’ about the role of Local Education Offices. Our findings suggest that the heuristic makes a contribution to evaluating support systems in the regional context and might be applicable in a more general context also. (DIPF/Orig.)
Storage Workload Characterization and Consolidation in Virtualized Environments

Server virtualization is accelerating the already existing need for shared storage area network (SAN) infrastructure for the associated benefits of migration, flexible management and economies of sharing. Understanding the characteristics of a workload in terms of access locality, IO sizes, read write ratio etc. is crucial for effective placement and consolidation. The lack of visibility into workload details and placement often leads to design inefficiencies and overprovisioning. This paper presents workload characterization study of three top-tier enterprise applications using VMware ESX server hypervisor. We further separate out different components (for example data, index and redo log in a database) of these workloads to understand their behavior in isolation. We find that most workloads show highly random access patterns. Next, we study the impact of storage consolidation on workloads (both random and sequential) and their burstiness. Our experiments show that its beneficial to put random workloads together because it improves utilization and reduces latency without hurting performance. In case of consolidating random and sequential workloads, we see performance degradation for the sequential workload. Burst analysis reveals that most workloads are very bursty and the rate can change by as much as 50% within a few seconds. This makes it even more important to have the ability to absorb bursts and exploit benefits of statistical multiplexing by doing consolidation of workloads, whenever possible.
Students ' reading preferences : An exploratory study

The e-book reader revolution is here already. The questions we asked ourselves were: what are the reading preferences of information science students at the beginning of the second decade of the 21 century? How do different variables such as relative advantage, comprehension and learning strategies affect students' reading preferences? The research was conducted in Israel during the first semester of the 2015 academic year and encompassed 177 LIS students in the Information Science Department in Israel. Three questionnaires were used: personal details, relative advantage, and learning strategies, and two further questions that focus on reading habits. The study showed students' preferences of printed materials. In addition, it emphasizes the importance of personal variables that may affect students' will to read electronic materials: relative advantage and comprehension.
A New Future for Business? Rethinking Management Theory and Business Strategy

In this introductory article, we discuss the need for a rethinking of the theoretical foundations of management and the practice of business strategy in view of a range of social, environmental and ethical challenges that highlight the limits of ‘business as usual’. Calls for a reconsideration of current approaches have come to the fore in the fields of management, accounting, marketing and finance and we briefly review them here. We then introduce the four papers included in this special issue, each of which answers previously unechoed calls from different field of business research. We highlight how each paper contributes to novel perspectives on a future for business - perspectives that more adequately reflect the challenges faced today by both the private sector and society at large. Areas for further research are indicated as well.
Modelling sequential protein folding under kinetic control

MOTIVATION This study presents a novel investigation of the effect of kinetic control on cotranslational protein folding. We demonstrate the effect using simple HP lattice models and show that the cotranslational folding of proteins under kinetic control has a significant impact on the final conformation. Differences arise if nature is not capable of pushing a partially folded protein back over a large energy barrier. For this reason we argue that such constraints should be incorporated into structure prediction techniques. We introduce a finite surmountable energy barrier which allows partially formed chains to partly unfold, and permits us to enumerate exhaustively all energy pathways. RESULTS We compare the ground states obtained sequentially with the global ground states of designing sequences (those with a unique global ground state). We find that the sequential ground states become less numerous and more compact as the surmountable energy barrier increases. We also introduce a probabilistic model to describe the distribution of final folds and allow partial settling to the Boltzmann distribution of states at each stage. As a result, conformations with the highest probability of final occurrence are not necessarily the ones of lowest energy. AVAILABILITY Software available on request.
MediaEval 2013: Soundtrack Selection for Commercials Based on Content Correlation Modeling

This paper presents our approaches of soundtrack selection for commercials based on audio/visual correlation analysis. Two approaches are adopted. One is based on multimodal latent semantic analysis (MLSA) and the other is based on cross-modal factor analysis (CFA). The evaluation based on the MediaEval Soundtrack Selection for Commercials Dataset shows the performance of our systems.
Enabling the Extraction and Insertion of Reusable Choreography Fragments

Reuse of service orchestrations or service compositions is extensively studied in the literature of process modeling. Sub-processes, process templates, process variants, and process reference models are employed as reusable elements for these purposes. The concept of process fragments has been previously introduced in order to capture parts of a process model and store them for later reuse. However, similar efforts on facilitating the reuse of processes that cross the boundaries of organizations expressed as service choreographies are not available yet. In this paper, we introduce the concept of choreography fragments as reusable elements for service choreography modeling. Choreography fragments can be extracted from choreography models, adapted, stored, and later inserted into new models. Based on a formal model for choreography fragments, we define methods and algorithms for the extraction and insertion of fragments from and into service choreographies. We then discuss an experimental and proof-of-concept evaluation of our proposal.
Asymptotically Efficient Estimation of Models Defined by Convex Moment Inequalities

This paper examines the efficient estimation of partially identified models defined by moment inequalities that are convex in the parameter of interest. In such a setting, the identified set is itself convex and hence fully characterized by its support function. We provide conditions under which, despite being an infinite dimensional parameter, the support function admits √n‐consistent regular estimators. A semiparametric efficiency bound is then derived for its estimation, and it is shown that any regular estimator attaining it must also minimize a wide class of asymptotic loss functions. In addition, we show that the “plug‐in” estimator is efficient, and devise a consistent bootstrap procedure for estimating its limiting distribution. The setting we examine is related to an incomplete linear model studied in Beresteanu and Molinari (2008) and Bontemps, Magnac, and Maurin (2012), which further enables us to establish the semiparametric efficiency of their proposed estimators for that problem.
Which Boolean functions are most informative?

We introduce a simply stated conjecture regarding the maximum mutual information a Boolean function can reveal about noisy inputs. Specifically, let X<sup>n</sup> be i.i. d. Bernoulli(l/2), and let Y<sup>n</sup> be the result of passing X<sup>n</sup> through a memoryless binary symmetric channel with crossover probability α. For any Boolean function b : {0, l}<sup>n</sup> → {0,1}, we conjecture that I(b(X<sup>n</sup>);Y<sup>n</sup>) ≤ 1 - H (α). While the conjecture remains open, we provide substantial evidence supporting its validity.
Design of Tool for Digital Forensics in Virtual Environment

Virtual Environment Forensics is the process of performing the digital forensics in virtual environment. In recent time, virtualization technology has become one of the most important and popular technologies for individuals and companies due to its many advantages like cost benefits for storage, processing and computing resources. New techniques and methods of cybercrimes against virtual environments are used by attackers. Thus there is a need for designing and developing new techniques and tools to investigate new type of cybercrimes. [1] In this paper, the computer forensic investigations with respect to the vital role of virtual environments have been analysed. Vulnerabilities in a virtual environment and some existing forensic tools are studied. We propose design of a forensic tool to analyse the evidences left by an attacker. Further this tool will try to relate the evidences in a presentable form which can be readily used by law enforcement to lead to the final suspect.
Metabolism of 9-β-d-Arabinofuranosyladenine by Mouse Fibroblasts

The metabolism of 9-β-d-arabinofuranosyladenine (araA) by exponentially growing mouse fibroblasts in suspension culture has been investigated. After a 4-hr incubation with 0.1 mm [3H]araA, only 0.14% of the total 3H was in the cell fraction, whereas 48% of the araA in the medium had been deaminated to 9-β-d-arabinofuranosylhypoxanthine. Of the cellular 3H, 80% was acid soluble, and of these 75% was associated with adenine nucleotides and 25% was associated with nucleosides. 9-β-d-arabinofuranosylhypoxanthine comprised 80% of the labeled nucleosides, the rest being araA or adenosine. Following dephosphorylation of the acid-soluble fraction, 80% of the 3H was in araA and 9-β-d-arabinofuranosylhypoxanthine, and 18% was in adenosine. Ninety % of the 3H in the adenine-containing triphosphates was shown to be in arabinosyl compounds, and the remainder was in adenosine and deoxyadenosine. The concentration of cellular 9-β-d-arabinofuranosyladenine 5′-triphosphate was calculated to be 20 µm. The RNA fraction contained 16% of the total cellular 3H. Over 90% of the 3H was associated with the adenosine 2′(3′)-phosphate fraction; the remainder was nucleoside, mainly araA. When the adenosine 2′(3′)-phosphate fraction was dephosphorylated, nearly 70% of the 3H was contained in adenosine, indicating extensive metabolism of araA. The remaining 3H was associated with arabinosyl compounds. The DNA fraction contained 2% of the cellular 3H. After degradation to 5′-monophosphates, the 3H was found mainly in 9-β-d-arabinofuranosyladenine 5′-phosphate; after dephosphorylation 95% of the 3H was in araA. Following degradation to 3′-monophosphates and terminal nucleosides, the majority of the 3H was associated with 9-β-d-arabinofuranosyladenine 3′-phosphate, whereas a minor portion was in the nucleoside. These results suggest that, after incubation with mouse fibroblasts, most of the exogenous araA is deaminated and remains in the medium or is otherwise metabolized. A small amount is phosphorylated to arabinosyl nucleotides that attain inhibitory cellular concentrations, and some 9-β-d-arabinofuranosyladenine 5′-triphosphate is subsequently incorporated in internucleotide linkage into DNA.
Innovation Rate Sampling of Pulse Streams With Application to Ultrasound Imaging

Signals comprised of a stream of short pulses appear in many applications including bioimaging and radar. The recent finite rate of innovation framework, has paved the way to low rate sampling of such pulses by noticing that only a small number of parameters per unit time are needed to fully describe these signals. Unfortunately, for high rates of innovation, existing sampling schemes are numerically unstable. In this paper we propose a general sampling approach which leads to stable recovery even in the presence of many pulses. We begin by deriving a condition on the sampling kernel which allows perfect reconstruction of periodic streams from the minimal number of samples. We then design a compactly supported class of filters, satisfying this condition. The periodic solution is extended to finite and infinite streams and is shown to be numerically stable even for a large number of pulses. High noise robustness is also demonstrated when the delays are sufficiently separated. Finally, we process ultrasound imaging data using our techniques and show that substantial rate reduction with respect to traditional ultrasound sampling schemes can be achieved.
Tandem Repeat Modification during Double-Strand Break Repair Induced by an Engineered TAL Effector Nuclease in Zebrafish Genome

Tandem repeats (TRs) are abundant and widely distributed in eukaryotic genomes. TRs are thought to have various functions in gene transcription, DNA methylation, nucleosome position and chromatin organization. Variation of repeat units in the genome is observed in association with a number of diseases, such as Fragile X Syndrome, Huntington's disease and Friedreich's ataxia. However, the underlying mechanisms involved are poorly understood, largely owing to the technical limitations in modification of TRs at definite sites in the genome in vivo. Transcription activator-like effector nucleases (TALENs) are widely used in recent years in gene targeting for their specific binding to target sequences when engineered in vitro. Here, we show that the repair of a double-strand break (DSB) induced by TALENs adjacent to a TR can produce serial types of mutations in the TR region. Sequencing analysis revealed that there are three types of mutations induced by the DSB repair, including indels only within the TR region or within the flanking TALEN target region or simutaneously within both regions. Therefore, desired TR mutant types can be conveniently obtained by using engineered TALENs. These results demonstrate that TALENs can serve as a convenient tool for modifying TRs in the genome in studying the functions of TRs.
Spatial contrast sensitivity of dark-reared cats with striate cortex lesions

We measured the spatial contrast sensitivity of two dark-reared cats before and after bilateral ablations of area 17 and parts of area 18. These lesions produced large deficits in the contrast sensitivity of both cats at intermediate and high spatial frequencies. This postoperative reduction in contrast sensitivity in dark-reared cats is relatively similar to the sensitivity deficits produced by the same cortical lesions in normally reared cats. However, both pre- and postoperatively, the normally reared cats exhibited contrast sensitivity that is clearly superior to that of the dark-reared cats. The results demonstrate both that striate cortex is significantly involved in the spatial contrast sensitivity of dark-reared cats and that dark rearing produces widespread deficits, independent of those in striate cortex, through much of the visual system.
ANTAGONISTIC ACTIVITY OF TWO BACILLUS SP. STRAINS ISOLATED FROM AN ALGERIAN SOIL TOWARDS THE MIGRATORY LOCUST LOCUSTA MIGRATORIA (LINNAEUS 1758)

The aim of our study is to isolate, purify and characterize two entomopathogenic bacterial strains of the genus Bacillus from the soil of Adrar in the Algerian Sahara. The molecular characterization of the isolated strains was carried out by DNA isolation, PCR and sequencing of 16S rRNA gene, followed by a phylogenetic analysis. After that, the study of the bacteria toxicity on the fifth larvae stage of Locusta migratoria was conducted by assessing rates of mortality, LT50 and LC50. The phylogenetic analysis showed that the two strains (Strain-B1 and Strain -B2) were identified as Bacillus sp. (HE799656) and Bacillus sp. (HE805963), respectively, with a very high similarity (99%) with the strains Bacillus thuringiensis (NR_043403) and Bacillus weihenstephanensis (NR_024697). Besides, the results of toxicity tests showed that larvae of L. migratoria are influenced by the two isolated bacterial strains. This action is more pronounced with the Bacillus sp. strain-B1 (HE799656) compared to Bacillus sp. strain-B2 (HE805963). Examination of TL50 shows that these times vary depending on the bacteria and concentrations applied. Similarly, the LC50 are closely related with time and they also vary depending on the bacterial strain tested.
Multifeature Landmark-Free Active Appearance Models: Application to Prostate MRI Segmentation

Active shape models (ASMs) and active appearance models (AAMs) are popular approaches for medical image segmentation that use shape information to drive the segmentation process. Both approaches rely on image derived landmarks (specified either manually or automatically) to define the object's shape, which require accurate triangulation and alignment. An alternative approach to modeling shape is the level-set representation, defined as a set of signed distances to the object's surface. In addition, using multiple image derived attributes (IDAs) such as gradient information has previously shown to offer improved segmentation results when applied to ASMs, yet little work has been done exploring IDAs in the context of AAMs. In this work, we present a novel AAM methodology that utilizes the level set implementation to overcome the issues relating to specifying landmarks, and locates the object of interest in a new image using a registration based scheme. Additionally, the framework allows for incorporation of multiple IDAs. Our multifeature landmark-free AAM (MFLAAM) utilizes an efficient, intuitive, and accurate algorithm for identifying those IDAs that will offer the most accurate segmentations. In this paper, we evaluate our MFLAAM scheme for the problem of prostate segmentation from T2-w MRI volumes. On a cohort of 108 studies, the levelset MFLAAM yielded a mean Dice accuracy of 88% ± 5%, and a mean surface error of 1.5 mm ± . 8 mm with a segmentation time of 150/s per volume. In comparison, a state of the art AAM yielded mean Dice and surface error values of 86% ± 9% and 1.6 mm ± 1.0 mm, respectively. The differences with respect to our levelset-based MFLAAM model are statistically significant (p <; .05). In addition, our results were in most cases superior to several recent state of the art prostate MRI segmentation methods.
Comparative Functional Genomics of the Fission Yeasts

A combined analysis of genome sequence, structure, and expression gives insights into fission yeast biology. The fission yeast clade—comprising Schizosaccharomyces pombe, S. octosporus, S. cryophilus, and S. japonicus—occupies the basal branch of Ascomycete fungi and is an important model of eukaryote biology. A comparative annotation of these genomes identified a near extinction of transposons and the associated innovation of transposon-free centromeres. Expression analysis established that meiotic genes are subject to antisense transcription during vegetative growth, which suggests a mechanism for their tight regulation. In addition, trans-acting regulators control new genes within the context of expanded functional modules for meiosis and stress response. Differences in gene content and regulation also explain why, unlike the budding yeast of Saccharomycotina, fission yeasts cannot use ethanol as a primary carbon source. These analyses elucidate the genome structure and gene regulation of fission yeast and provide tools for investigation across the Schizosaccharomyces clade.
Screening of Substrate Analogs as Potential Enzyme Inhibitors for the Arginine Kinase of Trypanosoma cruzi

Abstract Arginine kinase catalyzes the transphosphorylation between phosphoarginine and ADP. Phosphoarginine is involved in temporal ATP buffering and inorganic phosphate regulation. Trypanosoma cruzi arginine kinase phosphorylates only l-arginine (specific activity 398.9 · mUE·min–1 · mg–1), and is inhibited by the arginine analogs, agmatine, canavanine, nitroarginine, and homoarginine. Canavanine and homoarginine also produce a significant inhibition of the epimastigote culture growth (79.7% and 55.8%, respectively). Inhibition constants were calculated for canavanine and homoarginine (7.55 and 6.02 mM, respectively). In addition, two novel guanidino kinase activities were detected in the epimastigote soluble extract. The development of the arginine kinase inhibitors of T. cruzi could be an important feature because the phosphagens biosynthetic pathway in trypanosomatids is different from the one in their mammalian hosts.
Pseudo-reference for motion transfer based on autonomous control system with an orbit attractor

Skill or motion transfer from someone to other persons is always required for dance teaching, rehabilitation, sports and so on. For teaching or transfer of motion, a dance notation and display of sequence of motion are often used effectively. However, these contain only the instantaneous postures of motion or professional subjective sense, it is not easy for beginners to understand the dynamical knack of motion. In this paper, we propose “pseudo-reference” that is a virtual target posture in the human motion. The pseudo-reference is developed based on the modeling of the human motion by the attractor design method which realizes an autonomous system. By comparing the nonlinear controller with conventional control systems (1DOF and 2DOF control system), the pseudo-reference is obtained as an embodiment of the implicit reference. The proposed method is performed with the inverted pendulum system and the tap dancing robot, and the validity and feasibility for motion transfer of the pseudo-reference are evaluated.