Miracle-dz/UniFAR-FTUs huggingface dataset:
Herbert capsuloplasty and Burnei tenomyoplasty for the correction of genu flexum in cerebral palsy, arthrogryposis and posttraumatic.

INTRODUCTION Studies of gait dynamics revealed the complex motions that the knee must undergo in sync with the hip and ankle, in both the swing and support phase of walking. If these motions are restricted, usually as a consequence of cerebral palsy or arthrogryposis, normal gait is hindered; the patient may be able to walk for very short distances or, eventually, not at all. Children with knee extension limited by 10 - 30 degrees,especially those with cerebral palsy, exhibit a stance compatible with walking. Walking is difficult and the gait pattern, "crouch gait", is considered typical for this degree of limitation. AIM This paper is meant as an update regarding the usefulness of Herbert knee capsuloplasty, conceived in 1938 and introduced in Romania in 1956 by Clement Baciu, and Burneidistal medial hamstring tenomyoplasty, invented in 1993. MATERIALS AND METHODS Herbert knee capsuloplasty, although initially intended for ailments other than spasticity or arthrogryposis,became known, in time, as a useful operation for spastic genu flexum with a 15 to 30 degree limitation of extension. Severing the posterior cruciate ligament (PCL) in children less than 10 years old often results in genu recurva tumor joint instability. In order to avoid these complications, PCL transection has been phased out and our clinic started to use, preferentially for spastic genu flexum rather than arthrogryposis,the Burnei tenomyoplasty. When applied in the same operative session, the two techniques complement each other and act in synergy. RESULTS Herbert capsuloplasty can achieve only partial correction of genu flexum ranging between 30 and 60 degrees of extension deficit. Full extension is opposed by the PCL,contracture of the hamstrings and vascular retraction. Burnei tenomyoplasty used by itself is useful for genu flexum with less than 30 degrees of extension deficit. For children with 30 to 60 degrees of knee extension deficit, combining the Herbertand Burnei procedures achieves the best results. CONCLUSIONS The simultaneous application of Herbert capsuloplasty and Burnei tenomyoplasty allows for the correction of stiff genu flexum and enables the patient to resume walking,with or without support. This course of treatment also avoids the progression of genu flexum beyond 60 degrees, which would require an osteotomy. This combined procedure avoids the cartilage lesions which may develop when patients with 30- 60 degree genu flexum undergo Herbert capsuloplasty alone.Not in the least, the risk of postoperative knee dislocation is significantly reduced.
Ocular Herpes Simplex Virus-1 T Cells into the Nervous System + CD8Development and Migration of Protective

After infection of epithelial surfaces, HSV-1 elicits a multifaceted antiviral response that controls the virus and limits it to latency in sensory ganglia. That response encompasses the CD8 (cid:1) T cells, whose precise role(s) is still being deﬁned; immune surveillance in the ganglia and control of viral spread to the brain were proposed as the key roles. We tracked the kinetics of the CD8 (cid:1) T cell response across lymphoid and extralymphoid tissues after ocular infection. HSV-1-speciﬁc CD8 (cid:1) T cells ﬁrst appeared in the draining (submandibular) lymph node on day 5 and were detectable in both nondraining lymphoid and extralymphoid tissues starting on day 6. However, although lymphoid organs contained both resting (CD43 low CFSE high ) and virus-speciﬁc cells at different stages of proliferation and activation, extralymphoid sites (eye, trigeminal ganglion, and brain) contained only activated cells that underwent more than eight proliferations (CD43 high CFSE neg ) and promptly secreted IFN- (cid:2) upon contact with viral Ags. Regardless of the state of activation, these cells appeared too late to prevent HSV-1 spread, which was seen in the eye (from day 1), trigeminal ganglia (from day 2), and brain (from day 3) well before the onset of a detectable CD8 (cid:1) T cell response. However, CD8 (cid:1) T cells were critical in reducing viral replication starting on day 6 and for its abrogation between days 8 and 10; CD8-deﬁcient animals failed to control the virus, exhibited persisting high viral titers in the brain after day 6, and died of viral encephalitis between days 7 and 12. Thus, CD8 (cid:1) T cells do not control HSV-1 spread from primary to tertiary tissues, but, rather, attack the Presence of antiviral CD8 (cid:1) T cells in the infected peripheral organs correlates with increased survival and lower viral titers in nervous tissues
Unsupervised Discovery of Generic Relationships Using Pattern Clusters and its Evaluation by Automatically Generated SAT Analogy Questions

We present a novel framework for the discovery and representation of general semantic relationships that hold between lexical items. We propose that each such relationship can be identified with a cluster of patterns that captures this relationship. We give a fully unsupervised algorithm for pattern cluster discovery, which searches, clusters and merges highfrequency words-based patterns around randomly selected hook words. Pattern clusters can be used to extract instances of the corresponding relationships. To assess the quality of discovered relationships, we use the pattern clusters to automatically generate SAT analogy questions. We also compare to a set of known relationships, achieving very good results in both methods. The evaluation (done in both English and Russian) substantiates the premise that our pattern clusters indeed reflect relationships perceived by humans.
Abstracting Parallel Programming and Its Analysis Towards Framework Independent Development

Since the appearance of parallel processors and their rapid diversification across a broad spectrum, developers must phrase algorithms in a parallel manner using originally imperative and thus inappropriate high-level languages. Language extensions as well as highly complex debugging methods (e.g., profilers) to handle concurrent and non-deterministic execution are therefore continuously developed. Most tools, however, suffer from inflexibility and platform dependencies. Moreover, binary-instrumenting profilers involve high overhead, influencing and thus deforming the runtime behavior. This may even hide critical behavior, thus developers still rely on their experience and often manually include measures in their software-code (in-line profiling). In this work, we propose a platform independent abstraction layer enabling a unified parallelization and runtime-flexible choice of the actual parallelization framework (e.g., OpenMP, TBB). Based on a source-code aware point of view, we further introduce an automated in-line profiling methodology in order to allow an objective rating of the parallelization success. Moreover, we automatically extract runtime influencing aspects and exemplarily apply these methodologies to implementations of two different video-based driver-assistance algorithms consid ering two different processor types.
Diagnostic Evaluation of Dementia in the Secondary Health Care Sector

Background: We conducted a nationwide registry-based study of the quality of diagnostic evaluation for dementia in the secondary health care sector. Method: Two hundred patients were randomly selected from the patient population (4,682 patients) registered for the first time with a dementia diagnosis in the nationwide hospital registries during the last 6 months of 2003. Through medical record review, we evaluated the completeness of the work-up on which the dementia diagnosis was based, using evidence-based dementia guidelines as reference standards. Results: Satisfactory or acceptable completion of the basic dementia work-up was documented in 51.3% of the patients. Only 11.5% of those with unsatisfactory work-up were referred to follow-up investigations. Dementia syndrome was confirmed in 88.5% of the cases, but correct subtypes were diagnosed in only 35.1%. Conclusion: The adherence to clinical guidelines concerning dementia work-up is inadequate in the secondary health care sector. Our findings call for improvement in the organization of clinical dementia care, for education of specialists and for changes in attitude towards making a diagnosis of dementia.
Sen-Witten orthonormal three-frame and gravitational energy quasilocalization

An expression for the Witten–Nester 4-spinor 3-form of the Hamiltonian density of the gravitational field in an asymptotically flat spacetime in terms of the Sommers–Sen spinors, direct with a certain orthonormal three-frame connection, is obtained. A direct connection between this and the ADM Hamiltonian density in the Sen–Witten frame is established on this basis.
Conserved synteny and gene order difference between human chromosome 12 and pig chromosome 5

A comparative map of human chromosome 12 (HSA 12) and pig chromosome 5 (SSC 5) was constructed using ten pig expressed sequence tags (ESTs). These ESTs were isolated from primary granulosa cell cultures by differential display (EST b10b), or from a granulosa cDNA library (VIIIE1, DRIM, N*9, RIIID2 and RVIC1) or from a small intestine cDNA library (ATPSB, ITGB7, MYH9, and STAT2). Also used were two Traced Orthologous Amplified Sequence Tags (TOASTs) (LALBA, TRA1), one microsatellite-associated gene (IGF1) and finally five human YACs selected for their cytogenetic position, with a view to increasing the number of informative markers for the comparison. Large-insert clones were obtained by screening a pig bacterial artificial chromosome (BAC) library with specific primers for each EST and TOAST and for IGF1. These BACs were used as probes for fluorescent in situ hybridisation (FISH) both on porcine and human metaphases. In addition, the human YACs were FISH mapped on pig chromosomes. This allowed us to refine and, in some cases, to correct the previous mapping obtained with a somatic cell hybrid panel. While these data confirm chromosome painting results showing that the distal part of SSC 5p arm is conserved on HSA 22, while the rest of the chromosome corresponds to HSA 12, they also demonstrate gene-order differences between human and pig. In addition, it was also possible to determine the position of the synteny breakpoint.
Expression of the yeast glycogen phosphorylase gene is regulated by stress‐response elements and by the HOG MAP kinase pathway

Yeast glycogen metabolism responds to environmental stressors such as nutrient limitation and heat shock. This response is mediated, in part, by the regulation of the glycogen metabolic genes. Environmental stressors induce a number of glycogen metabolic genes, including GPH1, which encodes glycogen phosphorylase. Primer extension analysis detected two start sites for GPH1, one of which predominated. Sequences upstream of these sites included a possible TATA element. Mutation of this sequence reduced GPH1 expression by a factor of 10 but did not affect start site selection. This mutation also did not affect the relative induction of GPH1 upon entry into stationary phase. Three candidates for stress response elements (STREs) were found upstream of the TATA sequence. Mutation of the STREs showed that they were required for regulation of GPH1 expression in early stationary phase, and in response to osmotic shock and heat shock. These elements appeared to act synergistically, since the intact promoter exhibited 30‐fold more expression in stationary phase than the sum of that observed for each element acting independently. HOG1, which encodes a MAP kinase, has been implicated in control mediated by STREs. For GPH1, induction by osmotic shock depended on a functional HOG1 allele. In contrast, induction upon entry into stationary phase was only partially dependent on HOG1. Furthermore, the heat shock response, which can also be mediated by STREs, was independent of HOG1. These observations suggest that the GPH1 STREs respond to more than one pathway, only one of which requires HOG1. Copyright © 2001 John Wiley & Sons, Ltd.
A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases-schizophrenia as a case

MOTIVATION During the past decade, we have seen an exponential growth of vast amounts of genetic data generated for complex disease studies. Currently, across a variety of complex biological problems, there is a strong trend towards the integration of data from multiple sources. So far, candidate gene prioritization approaches have been designed for specific purposes, by utilizing only some of the available sources of genetic studies, or by using a simple weight scheme. Specifically to psychiatric disorders, there has been no prioritization approach that fully utilizes all major sources of experimental data. RESULTS Here we present a multi-dimensional evidence-based candidate gene prioritization approach for complex diseases and demonstrate it in schizophrenia. In this approach, we first collect and curate genetic studies for schizophrenia from four major categories: association studies, linkage analyses, gene expression and literature search. Genes in these data sets are initially scored by category-specific scoring methods. Then, an optimal weight matrix is searched by a two-step procedure (core genes and unbiased P-values in independent genome-wide association studies). Finally, genes are prioritized by their combined scores using the optimal weight matrix. Our evaluation suggests this approach generates prioritized candidate genes that are promising for further analysis or replication. The approach can be applied to other complex diseases. AVAILABILITY The collected data, prioritized candidate genes, and gene prioritization tools are freely available at http://bioinfo.mc. vanderbilt.edu/SZGR/.
SemanticZ at SemEval-2016 Task 3: Ranking Relevant Answers in Community Question Answering Using Semantic Similarity Based on Fine-tuned Word Embeddings

We describe our system for finding good answers in a community forum, as defined in SemEval-2016, ask 3 on Community Question Answering. Our approach relies on several semantic similarity features based on fine-tuned word embeddings and topics similarities. In the main Subtask C, our primary submission was ranked third, with a MAP of 51.68 and accuracy of 69.94. In Subtask A, our primary submission was also third, with MAP of 77.58 and accuracy of 73.39.
Elastic and plastic deformations with rigid body dynamics

We present a fast and robust method of simulating flexible materials that offers significant advantages over existing methods. Our approach supports complex geometry (concave features, holes, selfintersections), requires no topology restrictions, boasts fast collisions, maintains volume, is numerically-stable for large time steps, and supports dynamic plasticity. Our approach provides an intuitive solution for modeling the complex dynamics of deformable solids with a predictable and production-friendly workflow.
Service Discovery and Delivery System Based on Trust in Mobile Ad-Hoc Network

Traditional service discovery protocols cannot be applied directly to mobile ad hoc networks because of their heterogeneity and mobility. It is also important to implement mechanisms to detect, as soon as possible, both the availability and unavailability of services produced when a device joins or leaves the network. Security in these networks is also critical because there are many chances of misuse both from fraudulent servers and from misbehaving clients. So, trust of devices and service discovery security is an important concern for mobile ad hoc network. In this paper, we propose the service discovery middleware with Trust of devices for the reliable service discovery and delivery between the devices in mobile ad-hoc network. The proposed system could discover and deliver stable service based on Trust of devices in the network because it avoided the security threat.
Online we are all able bodied : Online psychological sense of community and social support found through membership of disability-specific websites promotes well-being for people living with a physical disability

People with a physical disability are a population who for a number of reasons may be vulnerable to social isolation. Research into Internet-based support sites has found that social support and an online sense of community can be developed through computer mediated communication channels. This study aims to gain an understanding of the benefits that membership of disability-specific online communities may have for people with a physical disability. An online survey was administered to a sample of users of such sites (N = 160). Results indicated that users did receive moral support and personal advice through participating in such online communities. Further, results indicated that online social support and feeling a sense of community online were positively associated with participants' well-being in the areas of personal relations and personal growth.
Capturing discriminative information using multiple modeling techniques

An acoustic model is a simplified mathematical representation of acoustic-phonetic information. The simplifying assumptions inherent to each model entail that it may only be capable of capturing a certain aspect of the available information. An effective combination of different types of model should therefore permit a combined model that can utilize all the information captured by the individual models. This paper reports some preliminary research in combining certain types of acoustic model for speech recognition. In particular, we designed and implemented a single HMM framework, which combines a segment-based modeling technique with the standard HMM technique. The recognition experiments, based on a speaker-independent E-set database, have shown that the combined model has the potential of producing a significantly higher performance than the individual models considered in isolation.
Draft Genome Sequence for the Type Strain of Corynebacterium afermentans LCDC 88-0199T, Isolated from a Human Blood Culture

ABSTRACT A draft genome for Corynebacterium afermentans LCDC 88-0199T was investigated. The size of the genome was 2,345,615 bp with an observed G+C content of 64.85%. Annotation revealed 2 rRNA sequences, 54 tRNA genes, and 2,164 coding sequences. Genome coverage was 85× and consisted of 24 contigs with an N50 of 187,988 bp.
Involuntary capture of attention produces domain-specific activation

In this study, we ask whether or not the involuntary capture of attention by a specific information type can produce domain-specific activation. Participants indicated the presence of a flicker in rapidly alternating letter-string masks presented in the periphery. Despite letters not being relevant to the task, we found, using functional MRI and a novel task that allowed us to contrast attended and unattended processing of the same visual information, a robust modulation by attentional capture in a localized letter-processing region. This finding suggests that the involuntary capture of attention is sufficient to produce domain-specific activation in early visual processing.
Robust Common Spatial Filters with a Maxmin Approach

Electroencephalographic signals are known to be nonstationary and easily affected by artifacts; therefore, their analysis requires methods that can deal with noise. In this work, we present a way to robustify the popular common spatial patterns (CSP) algorithm under a maxmin approach. In contrast to standard CSP that maximizes the variance ratio between two conditions based on a single estimate of the class covariance matrices, we propose to robustly compute spatial filters by maximizing the minimum variance ratio within a prefixed set of covariance matrices called the tolerance set. We show that this kind of maxmin optimization makes CSP robust to outliers and reduces its tendency to overfit. We also present a data-driven approach to construct a tolerance set that captures the variability of the covariance matrices over time and shows its ability to reduce the nonstationarity of the extracted features and significantly improve classification accuracy. We test the spatial filters derived with this approach and compare them to standard CSP and a state-of-the-art method on a real-world brain-computer interface (BCI) data set in which we expect substantial fluctuations caused by environmental differences. Finally we investigate the advantages and limitations of the maxmin approach with simulations.
On static reachability analysis of IP networks

The primary purpose of a network is to provide reachability between applications running on end hosts. In this paper, we describe how to compute the reachability a network provides from a snapshot of the configuration state from each of the routers. Our primary contribution is the precise definition of the potential reachability of a network and a substantial simplification of the problem through a unified modeling of packet filters and routing protocols. In the end, we reduce a complex, important practical problem to computing the transitive closure to set union and intersection operations on reachability set representations. We then extend our algorithm to model the influence of packet transformations (e.g., by NATs or ToS remapping) along the path. Our technique for static analysis of network reachability is valuable for verifying the intent of the network designer, troubleshooting reachability problems, and performing "what-if" analysis of failure scenarios.
The Combination of Three Natural Compounds Effectively Prevented Lung Carcinogenesis by Optimal Wound Healing

The tumor stroma has been described as “normal wound healing gone awry”. We explored whether the restoration of a wound healing-like microenvironment may facilitate tumor healing. Firstly, we screened three natural compounds (shikonin, notoginsenoside R1 and aconitine) from wound healing agents and evaluated the efficacies of wound healing microenvironment for limiting single agent-elicited carcinogenesis and two-stage carcinogenesis. The results showed that three compounds used alone could promote wound healing but had unfavorable efficacy to exert wound healing, and that the combination of three compounds made up treatment disadvantage of a single compound in wound healing and led to optimal wound healing. Although individual treatment with these agents may prevent cancer, they were not effective for the treatment of established tumors. However, combination treatment with these three compounds almost completely prevented urethane-induced lung carcinogenesis and reduced tumor burden. Different from previous studies, we found that urethane-induced lung carcinogenesis was associated with lung injury independent of pulmonary inflammation. LPS-induced pulmonary inflammation did not increase lung carcinogenesis, whereas decreased pulmonary inflammation by macrophage depletion promoted lung carcinogenesis. In addition, urethane damaged wound healing in skin excision wound model, reversed lung carcinogenic efficacy by the combination of three compounds was consistent with skin wound healing. Further, the combination of these three agents reduced the number of lung cancer stem cells (CSCs) by inducing cell differentiation, restoration of gap junction intercellular communication (GJIC) and blockade of the epithelial-to-mesenchymal transition (EMT). Our results suggest that restoration of a wound healing microenvironment represents an effective strategy for cancer prevention.
Implementation of Selective Harmonic Elimination PWM switching strategy on DSTATCOM

Selective Harmonic Elimination PWM switching strategy has shown tremendous advantages in comparison with well-known SPWM strategy. But, its implementation on Distribution Static Var Compensator (DSTATCOM) is hard because of nonlinear nature of DSTATCOM and severe variation of DC capacitor voltage. In this paper, a controller based on PI controller is designed to overcome such problems. Thus, Modulation Index and phase angle of inverter are used as input control variables to regulate DC capacitor voltage and track reference reactive power. Simulations are worked out in MATLAB/Simulink environment.