Miracle-dz/UniFAR-FTUs huggingface dataset:
Out-of-Plane Bending of URM Walls Strengthened with FRP Strips –Modeling and Analysis

Synopsis: The modeling and analysis of un-reinforced masonry walls strengthened with externally bonded unidirectional composite laminates and subjected to out-ofplane loading is investigated. The model is based on variational principles, static equilibrium, and compatibility between the structural components, which include the masonry units (blocks), the mortar joints, the FRP strips, and the adhesive layers. The modeling of the masonry block and the mortar joints follows the small displacements and the Bernoulli-Euler beam theories. The strengthening FRP strips are modeled following the lamination theory and the adhesive layers are modeled as two dimensional linear elastic continuum. The effects of cracking of the mortar joints and the debonding of the composite laminates near the mortar joints are also considered. A numerical example is presented. The numerical results quantitatively describe some of the phenomena that govern the behavior of the strengthened wall and may lead to its failure. A summary and conclusions close the paper.
Distinct emotion regulation skills explain psychopathology and problems in social relationships following childhood emotional abuse and neglect

Abstract Efforts to differentiate between the developmental sequelae of childhood emotional abuse and childhood emotional neglect are critical to both research and practice efforts. As an oft-identified mechanism of the effects of child maltreatment on later adjustment, emotion dysregulation represents a key potential pathway. The present study explored a higher order factor model of specific emotion regulation skills, and the extent to which these skill sets would indicate distinct developmental pathways from unique emotional maltreatment experiences to multidomain adjustment. A sample of 500 ethnoracially diverse college students reported on their experiences. A two-factor model of emotion regulation skills based on subscales of the Difficulties in Emotion Regulation Scale was revealed. Significant indirect effects of childhood emotional abuse on psychopathology and problems in social relationships were found through response-focused difficulties in emotion regulation, whereas a significant indirect effect of childhood emotional neglect on problems in social relationships was found through antecedent-focused difficulties in emotion regulation. These results are consistent with theoretical models and empirical evidence suggesting differential effects of childhood emotional abuse and emotional neglect, and provide an important indication for developing targeted interventions focusing on specific higher order emotion dysregulation skill clusters.
Enriching the Design and Prototyping Loop: a Set of Tools to Support the Creation of Activity-Based Pervasive Applications

This paper proposes a complete approach to support the modelling, testing and prototyping of pervasive applications. It describes a set of tools aimed at supporting designers in the conceptualisation of their application and in the software development stage, and proposes a method for checking the validity of their design. For each step of the development life-cycle (design, prototyping and evaluation), we position the proposed approach with respect to related tools and methods. We also present a pervasive application implemented and evaluated using the proposed approach and tools, which facilitates further discussion of the benefits and disadvantages of using the proposed framework. We conclude with propositions for improvements to our comprehensive modelling, prototyping and testing framework for pervasive applications.
RNAi-Mediated Reverse Genetic Screen Identified Drosophila Chaperones Regulating Eye and Neuromuscular Junction Morphology

Accumulation of toxic proteins in neurons has been linked with the onset of neurodegenerative diseases, which in many cases are characterized by altered neuronal function and synapse loss. Molecular chaperones help protein folding and the resolubilization of unfolded proteins, thereby reducing the protein aggregation stress. While most of the chaperones are expressed in neurons, their functional relevance remains largely unknown. Here, using bioinformatics analysis, we identified 95 Drosophila chaperones and classified them into seven different classes. Ubiquitous actin5C-Gal4-mediated RNAi knockdown revealed that ∼50% of the chaperones are essential in Drosophila. Knocking down these genes in eyes revealed that ∼30% of the essential chaperones are crucial for eye development. Using neuron-specific knockdown, immunocytochemistry, and robust behavioral assays, we identified a new set of chaperones that play critical roles in the regulation of Drosophila NMJ structural organization. Together, our data present the first classification and comprehensive analysis of Drosophila chaperones. Our screen identified a new set of chaperones that regulate eye and NMJ morphogenesis. The outcome of the screen reported here provides a useful resource for further elucidating the role of individual chaperones in Drosophila eye morphogenesis and synaptic development.
Analytical Method Development and Validation for the Simultaneous Estimation of Abacavir and Lamivudine by Reversed-phase High-performance Liquid Chromatography in Bulk and Tablet Dosage Forms

Objective: A simple rapid, accurate, precise, and reproducible validated reverse phase high performance liquid chromatography (HPLC) method was developed for the determination of Abacavir (ABAC) and Lamivudine (LAMI) in bulk and tablet dosage forms. Methods: The quantification was carried out using Symmetry Premsil C18 (250 mm × 4.6 mm, 5 μm) column run in isocratic way using mobile phase comprising methanol: water (0.05% orthophosphoric acid with pH 3) 83:17 v/v and a detection wavelength of 245 nm and injection volume of 20 μl, with a flow rate of 1 ml/min. Results: In the developed method, the retention times of ABAC and LAMI were found to be 3.5 min and 7.4 min, respectively. The method was validated in terms of linearity, precision, accuracy, limits of detection, limits of quantitation, and robustness in accordance with the International Conference on Harmonization guidelines. Conclusion: The assay of the proposed method was found to be 99% – 101%. The recovery studies were also carried out and mean % recovery was found to be 99% – 101%. The % relative standard deviation from reproducibility was found to be <2%. The proposed method was statistically evaluated and can be applied for routine quality control analysis of ABAC and LAMI in bulk and in tablet dosage form.
Duration of Oxytocin and Rupture of the Membranes Before Diagnosing a Failed Induction of Labor

OBJECTIVE: To compare maternal and neonatal outcomes based on length of the latent phase during induction with rupture of membranes before 6 cm dilation. METHODS: This is a retrospective cohort study using data from the Consortium of Safe Labor study, including 9,763 nulliparous and 8,379 multiparous women with singleton, term pregnancies undergoing induction at 2 cm dilation or less with rupture of membranes before 6 cm dilation after which the latent phase ended. Outcomes were evaluated according to duration of oxytocin and rupture of membranes. RESULTS: At time points from 6 to 18 hours of oxytocin and rupture of membranes, the rates of nulliparous women remaining in the latent phase declined (35.9–1.4%) and the rates of vaginal delivery for those remaining in the latent phase at these time periods decreased (54.1–29.9%) Nulliparous women remaining in the latent phase for 12 hours compared with women who had exited the latent phase had significantly increased rates of chorioamnionitis (12.1% compared with 4.1%) and endometritis (3.6% compared with 1.3%) and increased rates of neonatal intensive care unit admission (8.7% compared with 6.3%). Similar patterns were present for multiparous women at 15 hours. CONCLUSION: Based on when neonatal morbidity increased, in an otherwise uncomplicated induction of labor with rupture of membranes, a latent phase after initiation of oxytocin of at least 12 hours for nulliparous women and 15 hours in multiparous women is a reasonable criterion for diagnosing a failed induction.
DRIMUX: Dynamic Rumor Influence Minimization with User Experience in Social Networks

With the soaring development of large scale online social networks, online information sharing is becoming ubiquitous everyday. Various information is propagating through online social networks including both the positive and negative. In this paper, we focus on the negative information problems such as the online rumors. Rumor blocking is a serious problem in large-scale social networks. Malicious rumors could cause chaos in society and hence need to be blocked as soon as possible after being detected. In this paper, we propose a model of dynamic rumor influence minimization with user experience (DRIMUX). Our goal is to minimize the influence of the rumor (i.e., the number of users that have accepted and sent the rumor) by blocking a certain subset of nodes. A dynamic Ising propagation model considering both the global popularity and individual attraction of the rumor is presented based on a realistic scenario. In addition, different from existing problems of influence minimization, we take into account the constraint of user experience utility. Specifically, each node is assigned a tolerance time threshold. If the blocking time of each user exceeds that threshold, the utility of the network will decrease. Under this constraint, we then formulate the problem as a network inference problem with survival theory, and propose solutions based on maximum likelihood principle. Experiments are implemented based on large-scale real world networks and validate the effectiveness of our method.
Analysis of HIV-1 Protease Gene Reveals Frequent Multiple Infections Followed by Recombination among Drug Treated Individuals Living in São Paulo and Santos, Brazil

The present study investigated the prevalence of HIV-1 multiple infections in a population composed by 47 patients under HAART failure and enrolled at the National DST/AIDS, Program, Ministry of Health, Brazil.Detection of multiple infections was done using a previously published RFLP assay for the HIV-1 protease gene, which is able of distinguishing between infections caused by a single or multiple HIV-1 subtypes. Samples with multiple infections were cloned, and sequence data submitted to phylogenetic analysis. We were able to identify 17 HIV-1 multiple infections out of 47 samples. Multiple infections were mostly composed by a mixture of recombinant viruses (94%), with only one case in which protease gene pure subtypes B and F were recovered. This is the first study that reports the prevalence of multiple infections and intersubtype recombinants in a population undergoing HAART in Brazil. Based on the data there was a steep increase of multiple infections after the introduction of the combined antiretroviral therapy in Brazil. Cases of multiple infections may be associated with HIV-1 genetic diversity through recombination allowing for the generation of viruses showing a combination of resistance mutations.
Design of an Intelligent Identity Detection System based on ECG Signal Processing

The main purpose of this paper is to develop a method to investigate heart signals for detection of the individuals. In this regard, data sets of 48 dual-channel ECG records were received from MIT-BIT data banks and used as the samples. Each of these samples was extracted during one hour at 128 Hz sampling rate for each individual. Each file was divided to time intervals of 10 seconds long and then analyzed using a wavelet transform down to level 10. For every level, entropy, power, energy, variance, standard deviation and average values (totally 60 features) were derived. All these 60 features were introduced for the first time, with the responding time and percentage being compared with those selected by an IDE feature selection. For this purpose, a threshold limit of the IDE equal to 0.8 was considered. Therefore, out of the 60 suggested features, only some 7 features (i.e. standard deviation of signal, energy of signal, variance of signal, power of signal, standard deviation of signal, power of signal, and standard deviation of signal) were found to be below the threshold limit. Afterwards, these 7 features were applied by difference classification methods to get the responding percentage and computational cost. The computational cost of knn method is smaller than other methods in both cases of selecting the features. On the other hand, in terms of accuracy of the XCSLA, selection of the features is the best method which has detected all classifications correctly using the IDE algorithm. Taking into account the results obtained from application of the developed classification systems for detecting identity of the individuals from their ECG signals based on their clinical symptoms can lead to make this conclusion that the proposed system may be an appropriate alternative for detection of the individuals as a biometric method. However, it is still necessary to conduct further research works on such a system. The main drawback of this system could stem from different feelings of a human being including anger, happiness, sadness and etc. which may change rhyme of the heartthrob.
Morphology control of polymer: Fullerene solar cells by nanoparticle self-assembly

During the past two decades, research in the field of polymer based solar cells has attracted great effort due to their simple processing, mechanical flexibility and potential low cost. A standard polymer solar cell is based on the concept of a bulkheterojunction composed of a conducting polymer as the electron donor and a fullerene derivative as the electron acceptor. Since the exciton lifetime is limited, this places extra emphasis on control of the morphology to obtain improved device performance. In this thesis, detailed characterization and novel morphological design of polymer solar cells was studied, in addition, preliminary efforts to transfer laboratory scale methods to industrialized device fabrication was made. Magnetic contrast neutron reflectivity was used to study the vertical concentration distribution of fullerene nanoparticles within poly(2,5-bis(3-tetradecylthiophen-2yl)thieno[3,2-b]thiophene (pBTTT) thin film. Due to the wide space between the side chains of polymer, these fullerene nanoparticles intercalate between them creating a stable co-crystal structure. Therefore, a high volume fraction of fullerene was needed to obtain optimal device performance as phase separated conductive pathways are required and resulted in a homogeneous fullerene concentration profile through the film. Small angle neutron scattering was used to find there is amorphous fullerene even at lower concentration since it was previously believed that all fullerene formed a cocrystal. These fullerene molecules evolve into approximately 15 nm sized agglomerates at higher concentrations to improve electron transport. Unfortunatedly, thermal annealing gives these agglomerates mobility to form micrometer sized crystals and reduce the device performance. In standard poly(3-hexylthiophene) (P3HT):[6,6]-phenyl-C61-butyric acid methyl ester (PCMBM) solar cells, a higher concentration of PCBM at the cathode interface
Lexical-semantic organization in bilingual children: evidence from a repeated word association task.

PURPOSE This study examined lexical-semantic organization of bilingual children in their 2 languages and in relation to monolingual age-mates. METHOD Twelve Mandarin-English bilingual and 12 English monolingual children generated 3 associations to each of 36 words. Responses were coded as paradigmatic (dog-cat) or syntagmatic (dog-bark). RESULTS Within the bilingual group, word association performance was comparable and correlated between 1st and 2nd languages. Bilingual and monolingual children demonstrated similar patterns of responses, but subtle group differences were also revealed. When between-group comparisons were made on English measures, there was a bilingual advantage in paradigmatic responding during the 1st elicitation and for verbs. CONCLUSION Results support previous studies in finding parallel development in bilinguals' 1st- and 2nd-language lexical-semantic skills and provide preliminary evidence that bilingualism may enhance paradigmatic organization of the semantic lexicon.
Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication

Diabetes is a pathological condition characterized by relative insulin deficiency, persistent hyperglycemia, and, consequently, diffuse micro- and macrovascular disease. One therapeutic strategy is to amplify insulin-secretion capacity by increasing the number of the insulin-producing β cells without triggering a generalized proliferative response. Here, we present the development of a small-molecule screening platform for the identification of molecules that increase β-cell replication. Using this platform, we identify a class of compounds [adenosine kinase inhibitors (ADK-Is)] that promote replication of primary β cells in three species (mouse, rat, and pig). Furthermore, the replication effect of ADK-Is is cell type-selective: treatment of islet cell cultures with ADK-Is increases replication of β cells but not that of α cells, PP cells, or fibroblasts. Short-term in vivo treatment with an ADK-I also increases β-cell replication but not exocrine cell or hepatocyte replication. Therefore, we propose ADK inhibition as a strategy for the treatment of diabetes.
MAXIMIZING STRENGTH DEVELOPMENT IN ATHLETES: A META‐ANALYSIS TO DETERMINE THE DOSE‐RESPONSE RELATIONSHIP

The efficiency, safety, and effectiveness of strength training programs are paramount for sport conditioning. Therefore, identifying optimal doses of the training variables allows for maximal gains in muscular strength to be elicited per unit of time and also for the reduction in risk of overtraining and/or overuse injuries. A quantified dose-response relationship for the continuum of training intensities, frequencies, and volumes has been identified for recreationally trained populations but has yet to be identified for competitive athletes. The purpose of this analysis was to identify this relationship in collegiate, professional, and elite athletes. A meta-analysis of 37 studies with a total of 370 effect sizes was performed to identify the dose-response relationship among competitive athletes. Criteria for study inclusion were (a) participants must have been competitive athletes at the collegiate or professional level, (b) the study must have employed a strength training intervention, and (c) the study must have included necessary data to calculate effect sizes. Effect size data demonstrate that maximal strength gains are elicited among athletes who train at a mean training intensity of 85% of 1 repetition maximum (1RM), 2 days per week, and with a mean training volume of 8 sets per muscle group. The current data exhibit different dose-response trends than previous meta-analytical investigations with trained and untrained nonathletes. These results demonstrate explicit dose-response trends for maximal strength gains in athletes and may be directly used in strength and conditioning venues to optimize training efficiency and effectiveness.
Human APOBEC3A Isoforms Translocate to the Nucleus and Induce DNA Double Strand Breaks Leading to Cell Stress and Death

Human APOBEC3 enzymes deaminate single stranded DNA. At least five can deaminate mitochondrial DNA in the cytoplasm, while three can deaminate viral DNA in the nucleus. However, only one, APOBEC3A, can hypermutate genomic DNA. We analysed the distribution and function of the two APOBEC3A isoforms p1 and p2 in transfected cell lines. Both can translocate to the nucleus and hypermutate CMYC DNA and induce DNA double strand breaks as visualized by the detection of ©H2AX or Chk2. APOBEC3A induced G1 phase cell cycle arrest and triggered several members of the intrinsic apoptosis pathway. Activation of purified human CD4+ T lymphocytes with PHA, IL2 and interferon α resulted in C->T hypermutation of genomic DNA and double stranded breaks suggesting a role for APOBEC3A in pro-inflammatory conditions. As chronic inflammation underlies many diseases including numerous cancers, it is possible that APOBEC3A induction may generate many of the lesions typical of a cancer genome.
Structural Insights into the TLA-3 Extended-Spectrum β-Lactamase and Its Inhibition by Avibactam and OP0595

ABSTRACT The development of effective inhibitors that block extended-spectrum β-lactamases (ESBLs) and restore the action of β-lactams represents an effective strategy against ESBL-producing Enterobacteriaceae. We evaluated the inhibitory effects of the diazabicyclooctanes avibactam and OP0595 against TLA-3, an ESBL that we identified previously. Avibactam and OP0595 inhibited TLA-3 with apparent inhibitor constants (Kiapp) of 1.71 ± 0.10 and 1.49 ± 0.05 μM, respectively, and could restore susceptibility to cephalosporins in the TLA-3-producing Escherichia coli strain. The value of the second-order acylation rate constant (k2/K, where k2 is the acylation rate constant and K is the equilibrium constant) of avibactam [(3.25 ± 0.03) × 103 M−1 · s−1] was closer to that of class C and D β-lactamases (k2/K, <104 M−1 · s−1) than that of class A β-lactamases (k2/K, >104 M−1 · s−1). In addition, we determined the structure of TLA-3 and that of TLA-3 complexed with avibactam or OP0595 at resolutions of 1.6, 1.6, and 2.0 Å, respectively. TLA-3 contains an inverted Ω loop and an extended loop between the β5 and β6 strands (insertion after Ser237), which appear only in PER-type class A β-lactamases. These structures might favor the accommodation of cephalosporins harboring bulky R1 side chains. TLA-3 presented a high catalytic efficiency (kcat/Km) against cephalosporins, including cephalothin, cefuroxime, and cefotaxime. Avibactam and OP0595 bound covalently to TLA-3 via the Ser70 residue and made contacts with residues Ser130, Thr235, and Ser237, which are conserved in ESBLs. Additionally, the sulfate group of the inhibitors formed polar contacts with amino acid residues in a positively charged pocket of TLA-3. Our findings provide a structural template for designing improved diazabicyclooctane-based inhibitors that are effective against ESBL-producing Enterobacteriaceae.
Intersession adaptation of the EEG-based detector of self-paced walking intention in stroke patients

Brain-computer interfaces (BCIs) have been used in patients with motor impairments as a rehabilitation tool, allowing the control of prosthetic devices with their brain signals. Typically, before each rehabilitation session a calibration phase is recorded to account for session-specific signal changes. Calibration is often an inconvenient process due to its length and patients' fatigue-proneness. This paper focuses on improving the performance of an EEG-based detector of walking intention for intersession transfer. Nine stroke subjects executed a self-paced walking task during three sessions, with one week between sessions. We performed an intersession adaptation by using 80% of one session's data and an additional 20% of a next session for training, and then we tested the detection model on the remaining part of the next session. In practice, this would constitute a longer initial calibration (40 minutes) and a shorter recalibration in subsequent sessions (10 minutes). After training set adaption we attain an average increase in performance of 13.5% over non-adaptive training. Furthermore, we used an approximation of Kullback-Leibler (KL) divergence to quantify the difference between training and testing sets for the non-adaptive and adaptive transfer. As a potential explanation for the improvement of intersession performance, we found a significant decrease in KL-divergence in the case of adaptive transfer.