Miracle-dz/UniFAR-FTUs huggingface dataset:
A New Hybrid Classification-Based Adaptive Error Concealment Technique for Image Transmission through Wireless Communication Channels

In image communications, error concealment is an effective technique for reconstruction of some of the lost contents in image or video during transmission in practical wireless communication channels. There are many known techniques for error concealment; each one gives a different degree of image quality. Thus, there is no preferred technique all the time because some of these techniques give a good objective image quality while others give a good subjective image quality. Multiple techniques can be used by making an image adaptive classification in transmitter, or receiver, to select the suitable technique for each block in the image. In this way, one uses the advantages of each technique to obtain better overall objective and subjective image quality. In (his paper, two algorithms for error concealment are considered, namely, the orientation-adaplive-sequential-lnterpolation (OASI) technique and the long- range-correlation (LRC) technique. The approach is to adaptively combine the two mentioned algorithms to get belter overall performance. Numerical examples show that the suggested hybrid technique results in improved performance over different examples of communication channel impairments including fading and additive noise. Combination of the suggested error concealment technique with channel coding including convolution coding and block interleaving is also considered.
Analysis of permanent-magnet machine for sensorless control based on high-frequency signal injection

Sensorless control of surface-mounted permanent-magnet (SMPM) machine is still a challenge. This paper presents the analysis of a SMPM machine for the sensorless control scheme based on high-frequency rotating voltage signal injection method. The method enables to track even the small saliencies typical for SMPM machine. In order to support this, the high-frequency inductances of a SMPM machine are analyzed by finite-element analysis (FEA) method. A rotating high-frequency model of a SMPM machine is developed and a sensorless rotor position and speed estimation algorithm is described. A commercial SMPM machine was used to do the experiments, and the speed and position estimation results are presented.
Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society.

OBJECTIVE Women with polycystic ovary syndrome (PCOS) often have cardiovascular disease (CVD) risk factors. The Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society created a panel to provide evidence-based reviews of studies assessing PCOS-CVD risk relationships and to develop guidelines for preventing CVD. PARTICIPANTS An expert panel in PCOS and CVD reviewed literature and presented recommendations. EVIDENCE Only studies comparing PCOS with control patients were included. All electronic databases were searched; reviews included individual studies/databases, systematic reviews, abstracts, and expert data. Articles were excluded if other hyperandrogenic disorders were not excluded, PCOS diagnosis was unclear, controls were not described, or methodology precluded evaluation. Inclusion/exclusion criteria were confirmed by at least two reviewers and arbitrated by a third. CONSENSUS PROCESS Systematic reviews of CVD risk factors were compiled and submitted for approval to the AE-PCOS Society Board. CONCLUSIONS Women with PCOS with obesity, cigarette smoking, dyslipidemia, hypertension, impaired glucose tolerance, and subclinical vascular disease are at risk, whereas those with metabolic syndrome and/or type 2 diabetes mellitus are at high risk for CVD. Body mass index, waist circumference, serum lipid/glucose, and blood pressure determinations are recommended for all women with PCOS, as is oral glucose tolerance testing in those with obesity, advanced age, personal history of gestational diabetes, or family history of type 2 diabetes mellitus. Mood disorder assessment is suggested in all PCOS patients. Lifestyle management is recommended for primary CVD prevention, targeting low-density and non-high-density lipoprotein cholesterol and adding insulin-sensitizing and other drugs if dyslipidemia or other risk factors persist.
The PDZ Protein Tax-interacting Protein-1 Inhibits β-Catenin Transcriptional Activity and Growth of Colorectal Cancer Cells*

Wnt signaling is essential during development while deregulation of this pathway frequently leads to the formation of various tumors including colorectal carcinomas. A key component of the pathway is β-catenin that, in association with TCF-4, directly regulates the expression of Wnt-responsive genes. To identify novel binding partners of β-catenin that may control its transcriptional activity, we performed a mammalian two-hybrid screen and isolated the Tax-interacting protein (TIP-1). The in vivo complex formation between β-catenin and TIP-1 was verified by coimmunoprecipitation, and a direct physical association was revealed by glutathione S-transferase pull-down experiments in vitro. By using a panel of deletion mutants of both proteins, we demonstrate that the interaction is mediated by the PDZ (PSD-95/DLG/ZO-1 homology) domain of TIP-1 and requires primarily the last four amino acids of β-catenin. TIP-1 overexpression resulted in a dose-dependent decrease in the transcriptional activity of β-catenin when tested on the TOP/FOPFLASH reporter system. Conversely, siRNA-mediated knock-down of endogenous TIP-1 slightly increased endogenous β-catenin transactivation function. Moreover, we show that overexpression of TIP-1 reduced the proliferation and anchorage-independent growth of colorectal cancer cells. These data suggest that TIP-1 may represent a novel regulatory element in the Wnt/β-catenin signaling pathway.
Clil in spanish education: proposal of a framework for implementing a technology-enhanced model of content and language integrated learning

Con este trabajo pretendemos contribuir a la mejora de la implementacion de la educacion bilingue, o mas concretamente, AICLE (Aprendizaje Integrado de Contenidos y Lengua Extranjera), en comunidades monolingues espanolas, donde este tipo de educacion es incipiente y presenta mas carencias, centrandonos principalmente en las necesidades del profesorado. Detectamos necesidades y deficiencias que puedan afectar negativamente a la aplicacion de AICLE en la educacion no universitaria de las comunidades monolingues en tres niveles: (1) nivel de investigacion, donde observamos la actividad investigadora sobre AICLE y otras formas de educacion bilingue especialmente en las comunidades mencionadas; (2) nivel oficial, en el que examinamos la cantidad y las caracteristicas de los principales programas oficiales de AICLE impulsados en la actualidad en estos contextos; y (3) nivel de aula, donde, mediante el diseno y la administracion de un cuestionario, pretendemos conocer la realidad diaria del profesorado. En general, el analisis de necesidades a nivel de aula sirve para confirmar las necesidades identificadas en los niveles previos. Entre otros aspectos, confirma la falta de formacion previa y continua del profesorado, sobre todo en aspectos de competencia linguistica y metodologicos. Los resultados muestran falta de colaboracion entre profesorado de diferentes areas, falta de informacion sobre AICLE, o deficiencias en la busqueda y diseno de materiales y recursos, por mencionar algunas. Con el fin de paliar estas deficiencias, hemos disenado un marco para guiar al profesorado en diferentes partes de la implementacion AICLE: (1) colaboracion entre el profesorado de L2 y el resto de asignaturas implicadas, (2) diseno, planificacion y aplicacion de la programacion AICLE, (3) diseno de materiales, y (4) uso de recursos. Este marco intenta impulsar un modelo AICLE basados en las TICs (Tecnologias de la Informacion y Comunicacion). Asi, dicho marco busca mejorar AICLE a traves del uso de la ELAO (Ensenanza de Lenguas Asistida por Ordenador) y, como consecuencia, intenta ofrecer un contexto adecuado para la integracion de la ELAO a traves del uso de la CLILQuest, un tipo de WebQuest para la ensenanza de lenguas extranjeras que depende inevitablemente de la instruccion dentro de AICLE.
Cómo publicar en revistas científicas de impacto: consejos y reglas sobre publicación científica, 4ª ed. [curso completo]

Publicar en las denominadas revistas cientificas de impacto, identificadas como aquellas indexadas en las bases de datos de Thomson-Reuters, se ha convertido en el objetivo principal de investigadores e instituciones de I+D. Por ello en este trabajo se presentan algunos consejos para maximizar las posibilidades de aceptacion de los manuscritos enviados a este tipo de revistas. En primer lugar def inimos que es una revista de impacto y sus beneficios tanto para investigadores como instituciones. A continuacion desarrollamos algunos aspectos a considerar durante la preparacion del manuscrito como la autoria, la elaboracion de tablas y graficas o la p reparacion de referencias bibliograficas. Una vez elaborado el manuscrito nos concentramos en los criterios fundamentales para seleccionar adecuadamente la revista. Por ultimo se repasan diferentes factores a tener en cuenta durante el proceso de envio par a, una vez enviado, centrarnos en el proceso de revision por pares y la respuesta a los revisores.
Embodying Others in Immersive Virtual Reality: Electro-Cortical Signatures of Monitoring the Errors in the Actions of an Avatar Seen from a First-Person Perspective

Brain monitoring of errors in one's own and other's actions is crucial for a variety of processes, ranging from the fine-tuning of motor skill learning to important social functions, such as reading out and anticipating the intentions of others. Here, we combined immersive virtual reality and EEG recording to explore whether embodying the errors of an avatar by seeing it from a first-person perspective may activate the error monitoring system in the brain of an onlooker. We asked healthy participants to observe, from a first- or third-person perspective, an avatar performing a correct or an incorrect reach-to-grasp movement toward one of two virtual mugs placed on a table. At the end of each trial, participants reported verbally how much they embodied the avatar's arm. Ratings were maximal in first-person perspective, indicating that immersive virtual reality can be a powerful tool to induce embodiment of an artificial agent, even through mere visual perception and in the absence of any cross-modal boosting. Observation of erroneous grasping from a first-person perspective enhanced error-related negativity and medial–frontal theta power in the trials where human onlookers embodied the virtual character, hinting at the tight link between early, automatic coding of error detection and sense of embodiment. Error positivity was similar in 1PP and 3PP, suggesting that conscious coding of errors is similar for self and other. Thus, embodiment plays an important role in activating specific components of the action monitoring system when others' errors are coded as if they are one's own errors. SIGNIFICANCE STATEMENT Detecting errors in other's actions is crucial for social functions, such as reading out and anticipating the intentions of others. Using immersive virtual reality and EEG recording, we explored how the brain of an onlooker reacted to the errors of an avatar seen from a first-person perspective. We found that mere observation of erroneous actions enhances electrocortical markers of error detection in the trials where human onlookers embodied the virtual character. Thus, the cerebral system for action monitoring is maximally activated when others' errors are coded as if they are one's own errors. The results have important implications for understanding how the brain can control the external world and thus creating new brain–computer interfaces.
CMMSD: A Data Set for Note-Level Segmentation of Monophonic Music

A musical data set for note-level segmentation of monophonic music is presented. It contains 36 excerpts from commercial recordings of monophonic classical western music and features the instrument groups strings, woodwind and brass. The excerpts are self-contained phrases with a mean length of 17.97 seconds and an average of 20 notes. All phrases are played in moderate tempo, mostly with significant amounts of expressive articulation. A manually annotated ground truth splits each item into a sequence of the three states note, transition and rest. The set is designed as an open source project, aiming at the development and evaluation of algorithms for segmentation, music performance analysis and feature selection. This paper presents the process of ground truth labeling and a detailed description of the data set and its properties.
Effect of timing of carbohydrate ingestion on endurance exercise performance.

This study compared the effects of carbohydrate ingestion throughout exercise with ingestion of an equal amount of carbohydrate late in exercise. Eight well-trained men cycled 2 h at 70 +/- 1% VO2 peak, followed immediately by a 15-min performance ride, while ingesting either a 7% carbohydrate-electrolyte solution (CHO-7), an artificially sweetened placebo (CON), or the placebo for the first 90 min then a 21% glucose solution (CHO-0/21). At the start of the performance ride, plasma glucose averaged 4.2 +/- 0.2, 5.2 +/- 0.1, and 5.7 +/- 0.2 mmol.l-1 in CON, CHO-7, and CHO-0/21, respectively (all different, P < 0.05). Plasma insulin levels were similar just prior to the performance ride in CHO-7 and CHO-0/21, with both higher than CON. A similar pattern was observed with respiratory exchange ratio (RER). Work performed during the performance ride was significantly greater in CHO-7 (268 +/- 8 kJ) compared with CON (242 +/- 9 kJ). Performance in CHO-0/21 (253 +/- 10 kJ), however, was not improved compared with CON, despite higher plasma glucose levels and plasma insulin levels similar to CHO-7. Seven of the eight subjects performed best in CHO-7. In conclusion, performance was improved, relative to the control trial, only when carbohydrate was ingested throughout exercise. Carbohydrate ingestion late in exercise did not improve performance despite increases in plasma glucose and insulin.
Calcium homeostatic mechanisms operating in cultured postnatal rat hippocampal neurones following flash photolysis of nitrophenyl‐EGTA

1 We examined Ca2+ homeostatic mechanisms in cultured postnatal rat hippocampal neurones by monitoring the recovery of background‐subtracted fluo‐3 fluorescence levels at 20–22°C immediately following a rapid increase in Ca2+ levels induced by flash photolysis of the caged Ca2+ compound nitrophenyl‐EGTA (NP‐EGTA). 2 A variety of methods or drugs were used in an attempt to block specifically efflux of Ca2+ by the plasmalemmal Na+–Ca2+ exchanger or uptake of Ca2+ into mitochondria. 3 Many of the experimental manipulations produced a decrease in intracellular pH (pHi) measured in sister cultures using the pH‐sensitive dye 2′,7′‐bis‐(2‐carboxyethyl)‐5‐(and‐6)‐carboxyfluorescein (BCECF). Accordingly, in each case, we determined the appropriate amount of the weak base trimethylamine (TMA) required to restore baseline pHi prior to flash photolysis. 4 Blockade of the plasmalemmal Na+‐Ca2+ exchanger by replacement of external Na+ with either Li+ or N‐methyl‐d‐glucamine (NMDG) markedly reduced pHi, but did not affect the rate of recovery of fluo‐3 fluorescence intensities once pHi was restored. 5 Inhibition of mitochondrial Ca2+ uptake, using the protonophore carbonyl cyanide m‐chlorophenylhydrazone (CCCP), resulted in a reduction in pHi, which could be restored by the addition of 2 mm TMA. Under these conditions the rate of recovery of Ca2+ levels was significantly slower than in the controls. Similar results were found using the respiratory chain inhibitor rotenone. 6 We conclude that, when the potential effects of changes in pHi are taken into account, mitochondria appear to sequester significant amounts of Ca2+ in the neuronal preparations used.
A Dynamic Pool of Calcium in Catecholamine Storage Vesicles

Chromaffin vesicles contain very high concentration of Ca2+ (∼20–40 mm total), compared with ∼100 nm in the cytosol. Aequorin, a jellyfish photoprotein with Ca2+-dependent luminescence, measures [Ca2+] in specific subcellular compartments wherein proteins with organelle-specific trafficking domains are fused in-frame to aequorin. Because of the presence of vesicular trafficking domain within CgA we engineered sorting of an expressed human CgA-Aequorin fusion protein (hCgA-Aeq) into the vesicle compartment as confirmed by sucrose density gradients and confocal immunofluorescent co-localization studies. hCgA-Aeq and cytoplasmic aequorin (Cyto-Aeq) luminescence displayed linear functions of [Ca2+] in vitro, over >5 log10 orders of magnitude (r > 0.99), and down to at least 10–7 m sensitivity. Calibrating the pH dependence of hCgA-Aeq luminescence allowed estimation of [Ca2+]ves at granule interior pH (∼5.5). In the cytoplasm, Cyto-Aeq accurately determined [Ca2+]cyto under both basal ([Ca2+]cyto = 130 ± 35 nm) and exocytosis-stimulated conditions, confirmed by an independent reference technique (Indo-1 fluorescence). The hCgA-Aeq chimera determined vesicular free [Ca2+]ves = 1.4 ± 0.3 μm under basal conditions indicating that >99% of granule total Ca2+ is in a “bound” state. The basal free [Ca2+]ves/[Ca2+]cyto ratio was thus ∼10.8-fold, indicating active, dynamic Ca2+ uptake from cytosol into the granules. Stimulation of exocytotic secretion revealed prompt, dynamic increases in both [Ca2+]ves and [Ca2+]cyto, and an exponential relation between the two (y = 0.99 × e(1.53x), r = 0.99), reflecting a persistent [Ca2+]ves/[Ca2+]cyto gradient, even during sharp increments of both values. Studies with inhibitors of Ca2+ translocation (Ca2+-ATPase), Na+/Ca+-exchange, Na+/H+-exchange, and vesicle acidification (H+-translocating ATPase), documented a role for these four ion transporter classes in accumulation of Ca2+ inside the vesicles.
Estimation of genetic population variables for six radiographic criteria of hip dysplasia in a colony of Labrador Retrievers.

OBJECTIVE To estimate genetic population variables for 6 radiographic criteria of canine hip dysplasia (CHD). ANIMALS 664 full- and half-siblings from a colony of Labrador Retrievers. PROCEDURE Heritability estimates and genetic correlations were calculated for 6 radiographic criteria of CHD. Two evaluation protocols were compared: the grade of the most severely affected hip joint and the sum of the scores for both hip joints. The predictive performance of estimated breeding values was also evaluated. RESULTS The overall prevalence of CHD (Federation Cynologique Internationale grades C, D, and E) was 29.6%. Median age at radiographic examination was 377 days. Heritability for the total CHD grade, Norberg angle (NA), coverage of the femoral head (COV), craniodorsal acetabular rim (ACR), subchondral bone sclerosis (SUBCH), shape of the femoral head and neck (FHN), and osteoarthritic changes at the insertion site of the joint capsule (JC) was estimated as follows: 0.44, 0.43, 0.46, 0.37, 0.32, 0.21, and 0.05, respectively. Heritability estimates were slightly higher for the sum of the scores for both hip joints. If NA and COV were included as fixed effects in the model for the dependent variables ACR, SUBCH, FHN, and JC , then heritability of these traits significantly decreased (0.08 to 0.15). High scores of NA and COV lead to a significant increase of the scores of the remaining criteria. CONCLUSIONS AND CLINICAL RELEVANCE Canine hip dysplasia is heritable to a moderate degree. Signs of subluxation revealed the highest heritability estimates. The criteria ACR, SUBCH, FHN, and JC were strongly influenced by NA and COV.
Prognostic significance of the Bcl-2 negative germinal centre in patients with diffuse large B cell lymphoma treated with R-CHOP

The classification of germinal centre (GC) and non-GC is an important prognostic immunophenotype for patients with diffuse large B cell lymphoma (DLBCL) following anthracycline-based chemotherapy. The expression of the anti-apoptotic protein, Bcl-2, has been associated with an unfavourable prognosis in patients with DLBCL. Immunohistochemistry was performed using antibodies against CD10, Bcl-6, MUM-1 and Bcl-2. To establish the combined prognosis of the immunophenotype and Bcl-2 overexpression, patients were separated into four subgroups based on their gene expression profile: the Bcl-2 positive GC subgroup, Bcl-2 negative GC subgroup, Bcl-2 positive non-GC subgroup, and the Bcl-2 negative non-GC subgroup. The clinical characteristics and survival outcomes of the four patient subgroups were compared. Ninety-six patients with de novo DLBCL received R-CHOP (rituximab, cyclophosphamide, vincristine, adriamycin and prednisone) therapy. The baseline characteristics of the patient subgroups were similar. The Bcl-2 negative GC subgroup had a favourable progression-free and overall survival (OS) compared with the other three subgroups (p = 0.042, 0.043). Multivariate analysis confirmed that the Bcl-2 negative GC group was independently associated with progression-free survival and OS. The results of this study showed that the Bcl-2 negative GC patients had the most favourable prognosis among patients with DLBCL that received R-CHOP.
Sex-related differences in the presentation and outcome of out-of-hospital cardiopulmonary arrest: A multiyear, prospective, population-based study

Objective To examine whether previously observed sex-related differences in coronary artery disease syndromes also apply to patients with out-of-hospital sudden cardiac arrest, a probable subset of patients with coronary artery disease who are easy to recognize and are treated in a standardized fashion. Design Prospective, population-based study conducted over a 6-yr period. Setting A large urban municipality (population, 1.1 million) served by a single emergency medical services system with centralized medical direction and standardized protocols. Patients All patients with out-of-hospital, nontraumatic, primary cardiac arrest. Interventions Standardized advanced cardiac life support protocols. Measurements and Main Results During the 6 yrs of the study, 4147 consecutive patients were studied, 42% of whom were women (p < .001). Although women were significantly older than men (mean age, 68.7 ± 18 vs. 61.7 ± 17 yrs;p = .001), there were no significant differences for the percentages of witnessed and unwitnessed arrests, response intervals, and the length and type of treatment provided. Although men were more likely to have ventricular fibrillation/ventricular tachycardia on presentation (41% vs. 30%), women had more asystole (8.8% vs. 7%) and (organized) pulseless electrical activity than men (24% vs. 18%;p < .001). Nevertheless, more women were resuscitated (13.5% vs. 10.7%;p = .005), particularly women with non-ventricular fibrillation/ventricular tachycardia presentation (12.6% vs. 9.6%;p < .02). These differences were more pronounced when controlling for age (95% confidence interval, 1.44 [1.25–1.74]). Conclusions In cases of out-of-hospital sudden cardiac arrest, women have significantly better resuscitation rates than men, especially when controlling for age, particularly among women with non-ventricular fibrillation/ventricular tachycardia presentations. Additional studies are required to validate these observations, not only for long-term survival and external validity, but also for other potential genetic factors and potential discrepancies with other studies.