Miracle-dz/UniFAR-FTUs huggingface dataset:
Multicast multigroup beamforming for per-antenna power constrained large-scale arrays

Large in the number of transmit elements, multi-antenna arrays with per-element limitations are in the focus of the present work. In this context, physical layer multigroup multicasting under per-antenna power constrains, is investigated herein. To address this complex optimization problem low-complexity alternatives to semi-definite relaxation are proposed. The goal is to optimize the per-antenna power constrained transmitter in a maximum fairness sense, which is formulated as a non-convex quadratically constrained quadratic problem. Therefore, the recently developed tool of feasible point pursuit and successive convex approximation is extended to account for practical per-antenna power constraints. Interestingly, the novel iterative method exhibits not only superior performance in terms of approaching the relaxed upper bound but also a significant complexity reduction, as the dimensions of the optimization variables increase. Consequently, multicast multigroup beamforming for large-scale array transmitters with per-antenna dedicated amplifiers is rendered computationally efficient and accurate. A preliminary performance evaluation in large-scale systems for which the semi-definite relaxation constantly yields non rank-1 solutions is presented.
The Effect of SERCA1b Silencing on the Differentiation and Calcium Homeostasis of C2C12 Skeletal Muscle Cells

The sarcoplasmic/endoplasmic reticulum Ca2+ATPases (SERCAs) are the main Ca2+ pumps which decrease the intracellular Ca2+ level by reaccumulating Ca2+ into the sarcoplasmic reticulum. The neonatal SERCA1b is the major Ca2+ pump in myotubes and young muscle fibers. To understand its role during skeletal muscle differentiation its synthesis has been interfered with specific shRNA sequence. Stably transfected clones showing significantly decreased SERCA1b expression (cloneC1) were selected for experiments. The expression of the regulatory proteins of skeletal muscle differentiation was examined either by Western-blot at the protein level for MyoD, STIM1, calsequestrin (CSQ), and calcineurin (CaN) or by RT-PCR for myostatin and MCIP1.4. Quantitative analysis revealed significant alterations in CSQ, STIM1, and CaN expression in cloneC1 as compared to control cells. To examine the functional consequences of the decreased expression of SERCA1b, repeated Ca2+-transients were evoked by applications of 120 mM KCl. The significantly higher [Ca2+]i measured at the 20th and 40th seconds after the beginning of KCl application (112±3 and 110±3 nM vs. 150±7 and 135±5 nM, in control and in cloneC1 cells, respectively) indicated a decreased Ca2+-uptake capability which was quantified by extracting the maximal pump rate (454±41 μM/s vs. 144±24 μM/s, in control and in cloneC1 cells). Furthermore, the rate of calcium release from the SR (610±60 vs. 377±64 μM/s) and the amount of calcium released (843±75 μM vs. 576±80 μM) were also significantly suppressed. These changes were also accompanied by a reduced activity of CaN in cells with decreased SERCA1b. In parallel, cloneC1 cells showed inhibited cell proliferation and decreased myotube nuclear numbers. Moreover, while cyclosporineA treatment suppressed the proliferation of parental cultures it had no effect on cloneC1 cells. SERCA1b is thus considered to play an essential role in the regulation of [Ca2+]i and its ab ovo gene silencing results in decreased skeletal muscle differentiation.
Karl Popper's Theory of Science and Econometrics: The Rise and Decline of Social Engineering

Karl Popper is, in general, best known for his Logik der Forschung, translated into English in 1959 as The Logic of Scientific Discovery [1972b], an antipositivist work that, ironically, first appeared in 1934 as one of the Vienna Circle Schriften. It is there that he first developed his falsification thesis-that component of Popper's theory of science that has held sway over economists and social scientists in the second half of the twentieth century. Although Terence Hutchison first introduced economists to Karl Popper's ideas in 1938 in his Significance and Basic Postulates of Economic Theory, Popper seems to have been far more influential in econometrics than in any other field in economics. Popper gave the new field its animus; but, unlike developments in other fields, his ideas were integrated into economic theory without reference to him or his works. Consequently, Popper's influence on econometrics has gone virtually unnoticed. A similiar fate has befallen the early econometricians' dreams (inspired by Popper's philosophy of science) of developing a tool of social engineering for the betterment of society.
A randomized trial of treatment for acute anterior cruciate ligament tears.

BACKGROUND The optimal management of a torn anterior cruciate ligament (ACL) of the knee is unknown. METHODS We conducted a randomized, controlled trial involving 121 young, active adults with acute ACL injury in which we compared two strategies: structured rehabilitation plus early ACL reconstruction and structured rehabilitation with the option of later ACL reconstruction if needed. The primary outcome was the change from baseline to 2 years in the average score on four subscales of the Knee Injury and Osteoarthritis Outcome Score (KOOS)--pain, symptoms, function in sports and recreation, and knee-related quality of life (KOOS(4); range of scores, 0 [worst] to 100 [best]). Secondary outcomes included results on all five KOOS subscales, the Medical Outcomes Study 36-Item Short-Form Health Survey, and the score on the Tegner Activity Scale. RESULTS Of 62 subjects assigned to rehabilitation plus early ACL reconstruction, 1 did not undergo surgery. Of 59 assigned to rehabilitation plus optional delayed ACL reconstruction, 23 underwent delayed ACL reconstruction; the other 36 underwent rehabilitation alone. The absolute change in the mean KOOS(4) score from baseline to 2 years was 39.2 points for those assigned to rehabilitation plus early ACL reconstruction and 39.4 for those assigned to rehabilitation plus optional delayed reconstruction (absolute between-group difference, 0.2 points; 95% confidence interval, -6.5 to 6.8; P=0.96 after adjustment for the baseline score). There were no significant differences between the two treatment groups with respect to secondary outcomes. Adverse events were common in both groups. The results were similar when the data were analyzed according to the treatment actually received. CONCLUSIONS In young, active adults with acute ACL tears, a strategy of rehabilitation plus early ACL reconstruction was not superior to a strategy of rehabilitation plus optional delayed ACL reconstruction. The latter strategy substantially reduced the frequency of surgical reconstructions. (Funded by the Swedish Research Council and the Medical Faculty of Lund University and others; Current Controlled Trials number, ISRCTN84752559.)
Tree Based Scalable Indexing for Multi-Party Privacy-Preserving Record Linkage

Recently, the linking of multiple databases to identify common sets of records has gained increasing recognition in application areas such as banking, health, insurance, etc. Often the databases to be linked contain sensitive information, where the owners of the databases do not want to share any details with any other party due to privacy concerns. The linkage of records in different databases without revealing their actual values is an emerging research discipline known as privacy-preserving record linkage. Comparison of records in multiple databases requires significant time and computational resources to produce the resulting matching sets of records. At the same time, preserving the privacy of the data is becoming more problematic with the increase of database sizes. We propose a novel indexing (blocking) approach for privacy-preserving record linkage between multiple (more than two) parties. Our approach is based on Bloom filters to encode attribute values into bit vectors. The Bloom filters are used to construct a singlebit tree, where the encoded records are arranged into different blocks. The approach requires the parties to only participate in a secure summation protocol to find the best bits to construct the trees in a balanced manner. Leaf nodes of the trees will contain the blocks with encoded records. These blocks can finally be compared using private comparison and classification techniques to determine the similar record sets in different databases. Experiments conducted with datasets of sizes up-to one million records show that our protocol is scalable with both the size of the datasets and the number of parties, while providing better blocking quality and privacy than a phonetic based indexing approach.
Predictors and outcome of organizational cynicism and themoderated mediating effect of perceived organizational support among nurses in Pakistan

Over the years, researchers in the field of management have tried to explore the factors of negative attitudes among healthcare services staff. However, related studies in the context of organizational cynicism are limited. Thus, it is essential to investigate the factors and outcomes of organizational cynicism among the healthcare services staff. The current study aimed to establish the relationship of perception of ethical climate, horizontal violence and authentic leadership style as predictors and turnover intention as an outcome of organizational cynicism along the moderated mediating effect of perceived organizational support in the nursing profession. The study used a quantitative research design, and eight hundred and seventy questionnaires were distributed to collect data from nursing staff working in Punjab region of Pakistan using a non-probability multistage sampling technique. Exploratory factor analysis (EFA), confirmatory factor analysis (CFA), multivariate data normality tests, descriptive statistics and structural equation modeling (SEM) were applied to analyze the data. The results revealed a statistically significant direct relationship among the perceptions of ethical climate, horizontal violence, authentic leadership style, organizational cynicism and turnover intention. Subsequently, results showed the full mediating effect of organizational cynicism between perception of ethical climate and turnover intention while no mediation was found between horizontal violence and turnover intention. Additionally, results indicated a partial mediating effect of organizational cynicism between authentic leadership style and turnover intention. On the contrary, moderated mediating relationship of perceived organizational support could not proceed because of the insignificant mediating effect of organizational cynicism between horizontal violence and turnover intention. Findings of the current study contributed to the literature of organizational behavior by exploring the factors and outcomes of cynicism among healthcare services staff. The study has also practical implications for nursing managers and the Ministry of Health, Pakistan as the findings would enable them to understand the factors which directly or indirectly affect the negative attitudes among healthcare services staff.
Association of DPP4 Gene Polymorphisms with Type 2 Diabetes Mellitus in Malaysian Subjects

Background Genetic polymorphisms of the Dipeptidyl Peptidase 4 (DPP4) gene may play a role in the etiology of type 2 diabetes mellitus (T2DM). This study aimed to investigate the possible association of single nucleotide polymorphisms (SNPs) of the DPP4 gene in Malaysian subjects with T2DM and evaluated whether they had an effect on the serum levels of soluble dipeptidyl peptidase 4 (sDPP-IV). Method Ten DPP4 SNPs were genotyped by TaqMan genotyping assays in 314 subjects with T2DM and 235 controls. Of these, 71 metabolic syndrome (MetS) subjects were excluded from subsequent analysis. The odds ratios (ORs) and their 95% confidence interval (CIs) were calculated using multiple logistic regression for the association between the SNPs of DPP4 and T2DM. In addition, the serum levels of sDPP-IV were investigated to evaluate the association of the SNPs of DPP4 with the sDPP-IV levels. Results Dominant, recessive, and additive genetic models were employed to test the association of DPP4 polymorphisms with T2DM, after adjusting for age, race, gender and BMI. The rs12617656 was associated with T2DM in Malaysian subjects in the recessive genetic model (OR = 1.98, p = 0.006), dominant model (OR = 1.95, p = 0.008), and additive model (OR = 1.63, p = 0.001). This association was more pronounced among Malaysian Indians, recessive (OR = 3.21, p = 0.019), dominant OR = 3.72, p = 0.003) and additive model (OR = 2.29, p = 0.0009). The additive genetic model showed that DPP4 rs4664443 and rs7633162 polymorphisms were associated with T2DM (OR = 1.53, p = 0.039), and (OR = 1.42, p = 0.020), respectively. In addition, the rs4664443 G>A polymorphism was associated with increased sDPP-IV levels (p = 0.042) in T2DM subjects. Conclusions DPP4 polymorphisms were associated with T2DM in Malaysian subjects, and linked to variations in sDPP-IV levels. In addition, these associations were more pronounced among Malaysian Indian subjects.
Organophosphate Hydrolase in Conductometric Biosensor for the Detection of Organophosphate Pesticides

The research has developed an enzyme biosensor for the detection organophosphate pesticide residues. The biosensor consists of a pair of screen-printed carbon electrode (SPCEs). One of electrodes contains immobilized organophosphate hydrolase (OPH) on a chitosan membrane by cross-linking it with glutaraldehyde. The area of the electrodes was optimized to 3, 5, and 7 mm2. The OPH was isolated from Pseudomonas putida, and was purified by the ammonium sulfate precipitation method, with 6444 ppm (A) and 7865 ppm (B). The organophosphate pesticide samples were 0–100 ppb in tris-acetate buffer 0.05 M, pH 8.5. The results showed that the best performance of the biosensor was achieved by the enzyme A with an electrode area of 5 mm2. The sensitivity of the biosensor was between 3 and 32 µS/ppb, and the detection limit for the organophosphate pesticides was 40 ppb (diazinon), 30 ppb (malathion), 20 ppb (chlorpyrifos), and 40 ppm (profenofos).
Projectagami: A Foldable Mobile Device with Shape Interactive Applications

Projectagami is a foldable mobile device that leverages simple 2D origami form to give applications new affordances: enabling rapid customization of the device shape. This bridges the gap between differently sized touch screen devices, and enables a novel and mobile form of split screen touch interaction that deviates from traditional rectangular form. We show how a flexible mobile device with unrestricted folding can create more realistic and augmented experiences: building on people's existing abilities to manipulate real world objects. We demonstrate this with shape enhanced "Wizard of Oz" demo applications including a book, online shopping, a board game, street navigation, and a dynamic browser. Our prototype is tracked with a Kinect and uses a projector for visual output. In the future, we envision devices like Projectagami to be self-contained and extended to 3D form.
Application of Proximal Algorithms to Three Dimensional Deconvolution Microscopy

In microscopy, shot noise dominates image formation, which can be modeled as a Poisson process. The Richardson-Lucy method tends to converge slowly for large problems and is not flexible to the addition of nondifferentiable priors. In this project, proximal algorithms like ADMM and Chambolle-Pock are applied to three dimensional deconvolution and are shown to converge faster than Richardson-Lucy.
Examining Factors in the Research Institute on Addictions Self-Inventory (RIASI): Associations with Alcohol Use and Problems at Assessment and Follow-Up

Impaired driving is a leading cause of alcohol-related deaths and injuries. Rehabilitation or remedial programs, involving assessment and screening of convicted impaired drivers to determine problem severity and appropriate programs, are an important component of society’s response to this problem. Ontario’s remedial program, Back on Track (BOT), involves an assessment process that includes administration of the Research Institute on Addictions Self-Inventory (RIASI) to determine assignment to an education or treatment program. The purpose of this study is to identify factors within the RIASI and examine how factor scores are associated with alcohol use and problem indicators at assessment and six-month follow-up. The sample included 22,298 individuals who completed BOT from 2000 to 2005. Principal component factor analysis with varimax rotation was conducted on RIASI data and an eight factor solution was retained: (1) Negative Affect, (2) Sensation Seeking, (3) Alcohol-Quantity, (4) Social Conformity, (5) High Risk Lifestyle, (6) Alcohol Problems, (7) Interpersonal Competence, and (8) Family History. Regression analyses were conducted to examine associations between factors and alcohol and problem measures obtained at assessment and at follow-up. Most factors, except for Interpersonal Competence, were associated with more alcohol use and problems at assessment. A similar pattern was observed at 6-month follow-up, but interestingly some factors (Negative Affect, Sensation Seeking, Alcohol-Quantity and Family History) predicted fewer days of alcohol use. The Interpersonal Competence factor was associated with significantly lower levels of alcohol use and problems at both assessment and follow-up. This work suggests that the RIASI provides information on several domains that have important relationships with alcohol problem severity and outcomes.
Comparison of DNA Fingerprinting Methods for Use in Investigation of Type E Botulism Outbreaks in the Canadian Arctic

ABSTRACT Pulsed-field gel electrophoresis (PFGE), randomly amplified polymorphic DNA (RAPD) analysis, and automated ribotyping were compared for epidemiological typing of Clostridium botulinum type E using clinical and food isolates associated with four botulism outbreaks occurring in the Canadian Arctic. All type E strains previously untypeable by PFGE, even with the use of a formaldehyde fixation step, could be typed by the addition of 50 μM thiourea to the electrophoresis running buffer. Digestion with SmaI or XhoI followed by PFGE was used to link food and clinical isolates from four different type E botulism outbreaks and differentiate them from among 39 group II strains. Strain differentiation was unsuccessful with the automated ribotyping system, producing a single characteristic EcoRI fingerprint common to all group II strains. RAPD analysis of C. botulinum group II strains was not consistently reproducible with primer OPJ-6 or OPJ-13, apparently discriminating between epidemiologically related strains. A modified PFGE protocol was judged to be the most useful method for typing epidemiologically related C. botulinum type E strains, based on its ability to type all strains reproducibly and with an adequate level of discrimination.
Intrinsic Characteristics of Neighboring DNA Modulate Transposable Element Activity in Drosophila melanogaster

Identifying factors influencing transposable element activity is essential for understanding how these elements impact genomes and their evolution as well as for fully exploiting them as functional genomics tools and gene-therapy vectors. Using a genetics-based approach, the influence of genomic position on piggyBac mobility in Drosophila melanogaster was assessed while controlling for element structure, genetic background, and transposase concentration. The mobility of piggyBac elements varied over more than two orders of magnitude solely as a result of their locations within the genome. The influence of genomic position on element activities was independent of factors resulting in position-dependent transgene expression (“position effects”). Elements could be relocated to new genomic locations without altering their activity if ≥500 bp of genomic DNA originally flanking the element was also relocated. Local intrinsic factors within the neighboring DNA that determined the activity of piggyBac elements were portable not only within the genome but also when elements were moved to plasmids. The predicted bendability of the first 50 bp flanking the 5′ and 3′ termini of piggyBac elements could account for 60% of the variance in position-dependent activity observed among elements. These results are significant because positional influences on transposable element activities will impact patterns of accumulation of elements within genomes. Manipulating and controlling the local sequence context of piggyBac elements could be a powerful, novel way of optimizing gene vector activity.
Proteomic analysis of SP600125‐controlled TrkA‐dependent targets in SK‐N‐MC neuroblastoma cells: Inhibition of TrkA activity by SP600125

The c‐Jun N‐terminal kinase (JNK) is well known to play an important role in cell death signaling of the p75 neurotrophin receptor. However, little has been studied about a role of JNK in the signaling pathways of the tropomyosin‐related kinase A (TrkA) neurotrophin receptor. In this study, we investigated JNK inhibitor SP600125‐controlled TrkA‐dependent targets by proteomic analysis to better understand an involvement of JNK in TrkA‐mediated signaling pathways. PDQuest image analysis and protein identification results showed that hnRNP C1/C2, α‐tubulin, β‐tubulin homolog, actin homolog, and eIF‐5A‐1 protein spots were upregulated by ectopic expression of TrkA, whereas α‐enolase, peroxiredoxin‐6, PROS‐27, HSP70, PP1‐gamma, and PDH E1‐alpha were downregulated by TrkA, and these TrkA‐dependent upregulation and downregulation were significantly suppressed by SP600125. Notably, TrkA largely affected certain PTM(s) but not total protein amounts of the SP600125‐controlled TrkA‐dependent targets. Moreover, SP600125 strongly suppressed TrkA‐mediated tyrosine phosphorylation signaling pathways as well as JNK signaling, indicating that SP600125 could function as a TrkA inhibitor. Taken together, our results suggest that TrkA could play an important role in the cytoskeleton, cell death, cellular processing, and glucose metabolism through activation or inactivation of the SP600125‐controlled TrkA‐dependent targets.
Modeling and Mapping of Soil Salinity with Reflectance Spectroscopy and Landsat Data Using Two Quantitative Methods (PLSR and MARS)

The monitoring of soil salinity levels is necessary for the prevention and mitigation of land degradation in arid environments. To assess the potential of remote sensing in estimating and mapping soil salinity in the El-Tina Plain, Sinai, Egypt, two predictive models were constructed based on the measured soil electrical conductivity (ECe) and laboratory soil reflectance spectra resampled to Landsat sensor’s resolution. The models used were partial least squares regression (PLSR) and multivariate adaptive regression splines (MARS). The results indicated that a good prediction of the soil salinity can be made based on the MARS model (R2 = 0.73, RMSE = 6.53, and ratio of performance to deviation (RPD) = 1.96), which performed better than the PLSR model (R2 = 0.70, RMSE = 6.95, and RPD = 1.82). The models were subsequently applied on a pixel-by-pixel basis to the reflectance values derived from two Landsat images (2006 and 2012) to generate quantitative maps of the soil salinity. The resulting maps were validated successfully for 37 and 26 sampling points for 2006 and 2012, respectively, with R2 = 0.72 and 0.74 for 2006 and 2012, respectively, for the MARS model, and R2 = 0.71 and 0.73 for 2006 and 2012, respectively, for the PLSR model. The results indicated that MARS is a more suitable technique than PLSR for the estimation and mapping of soil salinity, especially in areas with high levels of salinity. The method developed in this paper can be used for other satellite data, like those provided by Landsat 8, and can be applied in other arid and semi-arid environments.