Miracle-dz/UniFAR-FTUs huggingface dataset:
Unruptured intracranial aneurysms and the Trial on Endovascular Aneurysm Management (TEAM): The principles behind the protocol.

BACKGROUND With the widespread availability of non-invasive imaging of the brain in an aging population, we are increasingly confronted with the problem of the incidental discovery of unruptured aneurysms. The management of these patients remains controversial. Endovascular treatment can prevent rupture, but involves immediate risks. Furthermore, successful treatment does not eliminate all risk of rupture. The safety and efficacy of endovascular treatment of unruptured aneurysms remain undetermined. Hence the balance of the risks and benefits is uncertain. A randomized trial is needed to assess the potential benefits of endovascular management of unruptured aneurysms. THE TRIAL TEAM (Trial on Endovascular Aneurysm Management) is a randomized trial comparing endovascular treatment versus conservative management of unruptured aneurysms. TEAM aims to recruit 2002 patients in 60 centers throughout the world over a 3-year period and to follow all patients for 10 years. The primary outcome is to verify if the clinical outcome (morbidity/mortality (modified Rankin scale > 2) related to the aneurysm or its treatment) can be improved from 8% to 4%. The study is funded by the Canadian Institutes of Health Research.
Effects of Aging and Education on False Memory

This study examined the effects of aging and education on participants' false memory for words that were not presented. Three age groups of participants with either a high or low education level were asked to study lists of semantically related words. Both age and education were found to affect veridical and false memory, as indicated in the recall and recognition of the studied word and nonstudied lures. A low education level had a negative effect on memory performance for both young and middle-aged adults. Older adults with a high level of education had a higher level of false memory than those with a lower education level. The results of this study are discussed in terms of the importance of education on false memory and mechanisms that create false memory of words in older adults.
A small polypeptide triggers complete degradation of light‐harvesting phycobiliproteins in nutrient‐deprived cyanobacteria.

Phycobilisomes are the multiprotein complexes predominantly responsible for harvesting light energy in cyanobacteria and some eukaryotic algae. When the cyanobacterium Synechococcus sp. strain PCC 7942 is deprived of an essential nutrient, the phycobilisomes are specifically and rapidly degraded. Degradation may be either partial (after phosphorus deprivation) or complete (after sulfur or nitrogen deprivation). We have developed a visual screen to obtain mutants unable to degrade their phycobilisomes upon nutrient starvation. Complementation of one of these mutants led to the identification of a gene, designated nblA, that encodes a 59 amino acid polypeptide essential for phycobilisome degradation. Transcription of nblA increases dramatically in sulfur‐ or nitrogen‐deprived cells and moderately in phosphorus‐deprived cells. Using the phosphorus‐regulated alkaline phosphatase (phoA) promoter as a tool, we engineered constructs from which we could control the expression of either sense or antisense nblA. Increased expression of sense nbLA caused complete phycobilisome degradation during phosphorus deprivation, while expression of antisense nblA prevented phycobilisome degradation. Hence, nblA is necessary, and may be sufficient, for the degradation of phycobilisomes under adverse environmental conditions. Further investigation of the mechanism by which nblA causes phycobilisome destruction may reveal general principles that govern the specificity of macromolecular complex degradation.
Multi-Scale Representation of High Frequency Market Liquidity

We introduce an event based framework of directional changes and overshoots to map continuous financial data into the so-called Intrinsic Network - a state based discretisation of intrinsically dissected time series. Defining a method for state contraction of Intrinsic Network, we show that it has a consistent hierarchical structure that allows for multi-scale analysis of financial data. We define an information theoretic measurement termed Liquidity that characterises the unlikeliness of price trajectories and argue that the new metric has the ability to detect and predict stress in financial markets. We show empirical examples within the Foreign Exchange market where the new measure not only quantifies liquidity but also acts as an early warning signal.
Activation of trehalase during growth induction by nitrogen sources in the yeast Saccharomyces cerevisiae depends on the free catalytic subunits of camp‐dependent protein kinase, but not on functional ras proteins

Addition of a nitrogen‐source to glucose‐repressed, nitrogen‐starved G0 cells of the yeast Saccharomyces cerevisiae in the presence of a fermentable carbon source induces growth and causes within a few minutes a five‐fold, protein‐synthesis‐independent increase in the activity of trehalase. Nitrogen‐activated trehalase could be deactivated in vitro by alkaline phosphatase treatment, supporting the idea that the activation is triggered by phosphorylation. Yeast strains containing only one of the three TPK genes (which encode the catalytic subunit of cAMP‐dependent protein kinase) showed different degrees of nitrogen‐induced trehalase activation. The order of effectiveness was different from that previously reported for glucose‐induced activation of trehalase in glucose‐derepressed yeast cells. Further reduction of TPK‐encoded catalytic subunit activity by partially inactivating point mutations in the remaining TPK gene further diminished nitrogen‐induced trehalase activation, while deletion of the BCY1 gene (which encodes the regulatory subunit) in the same strains resulted in an increase in the extent of activation. Deletion of the RAS genes in such a tpkw1 bcy1 strain had no effect. These results are consistent with mediation of nitrogen‐induced trehalase activation by the free catalytic subunits alone. They support our previous conclusion that cAMP does not act as second messenger in this nitrogen‐induced activation process and our suggestion that a novel nitrogen‐induced signaling pathway integrates with the cAMP pathway at the level of the free catalytic subunits of protein kinase A. Western blot experiments showed that the differences in the extent of trehalase activation were not due to differences in trehalase expression. On the other hand, we cannot completely exclude that protein kinase A influences the nitrogen‐induced activation mechanism itself rather than acting directly on trehalase. However, any such alternative explanation requires the existence of an additional, yet unknown, mechanism for activation of trehalase besides the well‐established regulation by protein kinase A.
Investigating personal determinants of phishing and the effect of national culture

Purpose – The purpose of the study was twofold: to investigate the correlation between a sample of personal psychological and demographic factors and resistance to phishing; and to investigate if national culture moderates the strength of these correlations. Design/methodology/approach – To measure potential determinants, a survey was distributed to 2,099 employees of nine organizations in Sweden, USA and India. Then, the authors conducted unannounced phishing exercises, in which a phishing attack targeted the same sample. Findings – Intention to resist social engineering, general information security awareness, formal IS training and computer experience were identified to have a positive significant correlation to phishing resilience. Furthermore, the results showed that the correlation between phishing determinants and employees’ observed that phishing behavior differs between Swedish, US and Indian employees in 6 out of 15 cases. Research limitations/implications – The identified determinants had, even.
No association between a polymorphism in the promoter region of the MAOA gene with antisocial personality traits in alcoholics.

AIMS We analysed the MAOAuVNTR functional polymorphism in the promoter region of the X-chromosomal monoamine oxidase A (MAOA) gene. Genotypes with three-repeat alleles were reported to be associated with antisocial as well as impulsive traits. METHODS The repeat number (3-5) of the MAOA polymorphism was determined in 169 male alcoholic subjects and 72 controls of German descent. Behavioural and personality traits were evaluated using the Brown-Goodwin Assessment for History of Lifetime Aggression, the Buss Durkee Hostility Inventory, as well as the Barrat Impulsiveness Score. A median split in Brown-Goodwin, Buss Durkee Irritability, Buss Durkee Assault and Barrat Impulsiveness Score was conducted. RESULTS High scores were found, i.e. 47.9% in Brown-Goodwin, 65.7% in Buss Durkee Irritability, 63.3% in Buss Durkee Assault and 59.8% in Barrat Impulsiveness Scale, indicating high impulsiveness, irritability and antisocial behaviour. Based on the results of these questionnaires, we detected no significant differences between the frequency of the three-repeat allele and high or low scores in alcoholics and controls. CONCLUSIONS Taken together, these findings suggest that the three-repeat allele of the MAOAuVNTR 30-bp polymorphism is not associated with impulsive and aggressive personality traits.
Closed loop smooth steering of unicycle-like vehicles

Within this paper it is shown that, provided a special choice for the system state equations is a priori made, the use of the simplest quadratic form as candidate Lyapunov function, directly leads to the definition of smooth and effective closed loop control laws for unicycle-like vehicles, suitable to be used for steering, path following, and navigation among assigned points. Some considerations about the curvature of the corresponding manoeuvres are also reported. <<ETX>>
Overexpression of Glucose Transporter-1 (GLUT-1) Predicts Poor Prognosis in Epithelial Ovarian Cancer

Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate the microarray data, mRNA and protein level of glucose transporter-1 (GLUT-1) was examined. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. Real-time PCR and immunohistochemistry demonstrated that GLUT-1 expression was significantly increased in EOC (p = .029 and p < .001, respectively). On survival analysis, GLUT-1 overexpression (HR = 4.80, p = .027) and lymph node metastases (HR = 8.35, p = .016) conferred a significantly worse overall survival. In conclusion, GLUT-1 expression is remarkably upregulated in EOC and predicts a poor overall survival.
mHealth applications for diabetes: User preference and implications for app development

Increasing diabetes prevalence has led to the need for more sustainable and person-centred services. The diabetes self-care mHealth marketplace is growing, but most effective/valued features are unknown. This study gauges diabetes app user opinion to inform development work. An analysis of diabetes mHealth apps informed design of a questionnaire sent to a random sample of 400 patients stratified by diabetes type and age. Responses were analysed by sub-group, and preferences were compared with current diabetes apps. App features included data storage/graphics, exercise tracking, health/diet, reminders/alarms, education. Questionnaire response rate was 59 per cent (234/400); 144/233 (62%) owned smartphones. Smartphone users expressed preference towards mHealth (101/142 (71%)), although diabetes use was low (12/163 (7%)). Respondents favoured many potential features, with similar preferences between diabetes types. This study demonstrates that while mHealth acceptance is high, current engagement is low. Engagement and functionality could be improved by including stakeholders in future development, driven by clinical/user need.
Data Profiling Model for Assessing the Quality Traits of Master Data Management

Enterprise Resource Planning (ERP) and Business Intelligence (BI) system demand progressive rules for maintaining the valuable information about customers, products, suppliers and vendors as data captured through different sources may not be of high quality due to human errors, in many cases. The problem encounters when this information is accessible across multiple systems, within same organization. Providing adequacy to this scattered data is a top agenda for any organization as maintaining the data is complicated, as having high quality data. Master Data Management (MDM) provides a solution to these problems by maintaining “a single reference of truth” with authoritative source of master data (Customer, products, employees etc). Master Data Management (MDM) is a highlighted concern now a day as valid data is the demand for strategic, tactical and operational steering of every organization. The lane to MDM initiates with the quality of data which demands for discovery of master data, profiling and analysis. As inadequacy of data may leads to adverse effects such as wrong decision, loss of time, bad results and unnecessary risk. Thus there is a need to deal with master data and quality of this specific data in a successful and efficient manner. For ensuring this purpose, an approach is proposed in this paper. The research focuses on development of a Model for Data Profiling to assess the level of Quality Traits for Master Data Management. Results are shown by executing the defined steps on TALEND tool over collected dataset. Thus, level of quality traits processes directly correlates with an organization’s ability to make the proper decisions and better
Coordination of Multiple Teams of Robots for an Optimal Global Plan

We consider multiple teams of heterogeneous robots, where each team is given a feasible task to complete in its workspace on its own, and where teams are allowed to transfer robots between each other. We study the problem of finding a coordination of robot transfers between teams to ensure an optimal global plan (with minimum makespan) so that all tasks can be completed as soon as possible by helping each other. We propose to solve this problem using answer set programming.
Macrophage-Dependent Cleavage of the Laminin Receptor α6β1 in Prostate Cancer

The laminin-binding integrin α6β1 plays a major role in determining the aggressive phenotype of tumor cells during metastasis. Our previous work has shown that cleavage of the α6β1 integrin to produce the structural variant α6pβ1 on tumor cell surfaces is mediated by the serine protease urokinase plasminogen activator (uPA). Cleavage of α6β1 increases tumor cell motility, invasion, and prostate cancer metastasis, and blockage of uPA inhibits α6pβ1 production. In human tumors, uPA and uPAR are expressed in tumor cells and tumor-associated macrophages (TAM). TAMs localize to solid tumors and contribute to increased tumor growth and the metastatic phenotype. In this study, we utilized a coculture system of PC-3 prostate tumor cells and macrophages [12-O-tetradecanoylphorbol-13-acetate (TPA)-differentiated human leukemia HL-60 cells] to investigate the hypothesis that macrophages stimulate the production of the prometastatic variant α6pβ1 on human prostate cancer cells via the uPA/uPAR axis. Our results indicate that adherent macrophages cocultured with PC-3 cells increased PC-3 uPAR mRNA, uPAR cell surface protein expression and α6 integrin cleavage. The stimulation does not require macrophage/tumor cell contact because macrophage conditioned medium is sufficient for increased uPAR transcription and α6 cleavage–dependent PC-3 cell invasion. The increased cleavage was dependent on uPAR because production was blocked by silencing RNA–targeting uPAR. These results indicate that macrophages can stimulate uPA/uPAR production in tumor cells which results in α6 integrin cleavage. These data suggest that TAMs promote prometastatic integrin-dependent pericellular proteolysis. Mol Cancer Res; 9(10); 1319–28. ©2011 AACR.
Development of Dance Learning System Using Human Depth Information

인체의 댄스 학습은 실제로 수업을 참여하지 않고는 복잡하고 연속적인 신체 움직임으로 이루어진 전문가의 동작을 효과적 으로 따라 하기는 어렵다. 본 논문에서는 인체 깊이 정보를 이용한 댄스 학습 시스템을 제안하고 있다. 제안한 시스템에서는 마 커 프리 동작 갭쳐를 활용하여 댄스 전문가들로부터 다양한 예제 동작들을 갭쳐하고, 온라인 댄스 레슨에 사용하기 위해 동작 데이터베이스에 저장한다. 학생은 타블렛이나 키오스크 PC와 같은 사용자 단말기를 통해 데이터베이스에서 원하는 동작을 선 택하고, 학습한 후 자신의 동작을 온라인 피드백을 받기 위해 강사에게 전송할 수 있다. 이 학습 과정에서 본 시스템은 네트워크 환경에서 학생과 강사가 효율적으로 동작 데이터를 교환하기 위해 빠르게 동작을 검색할 수 있는 방법과 다중 모드 화면을 제공 한다. 실험 결과에 따르면 본 시스템은 학생들의 댄스 스킬을 주어진 시간 안에 향상시킬 수 있다.
Best view selection of 3D models based on unsupervised feature learning and discrimination ability

In this poster, an approach for best view selection of 3D models is proposed, which is based on the framework that formulates the selection as a problem of evaluating views' discrimination ability. Firstly, different views' features are extracted by unsupervised feature learning. Then classifiers are trained to evaluate each view's discrimination ability. A view with the best classifier has the best discrimination ability, and it is chosen as the best view of the 3D model. At last, experiments show that 3D models of same class have similar best views.
Commentary: the first geriatric residency-fellowship in the United States.

nutrition and the prevention of chronic diseases. Publ Health Nutr. 2004;7:101–121. 8. United Nations Economic Commission for Europe (UN/ECE), Population Activities Unit (PAU). Ageing-Related Research Survey. New York and Geneva: UN/ECE; 1998. 9. The European Commission for Community Research. Fifth framework programme. www.europa. eu.int/comm/research/ 10. European Alzheimer’s Disease Consortium (EADC). www.eadc. alzheimer-europe.org 11. European Union Geriatric Medicine Society (EUGMS). www.eugms. org. 12. Duursma S, Castleden M, Cherubini A, et al. European Union Geriatric Medicine Society (EUGMS). Position statement on geriatric medicine and the provision of health care services to older people. JNHA. 2004;8:190–196. 13. Sieber C, Zekry D, Swine CH, Michel JP. Back to the future: the European Academy for Medicine of Ageing (EAMA) revisited. Gerontology. 2002;48:56–58. 14. Swine C, Michel JP, Duursma S, et al. Evaluation of the European Academy for Medicine of ageing ‘‘Teaching the Teachers’’ program (EAMA course II 1997–1998). JNHA. 2004;8:181–189. 15. Milisen K, de Geest S, Schuurmans, et al. Meeting the challenges for gerontological nursing in Europe: the European Nursing Academy for the care of older persons (ENACO). JNHA. 2004;8:197–199. 16. Robine JM, Michel JP. Looking forward to a general theory of aging population. J Gerontol Biol Sci Med Sci. 2004;59A:590–597. 17. International Classification of Functioning, Disability and Health. www.who. int/classification/ 18. Hogan DB, MacKnight C, Bergman H, et al. Models, definitions, and criteria of frailty. Aging Clin Exp Res. 2003;15(3 Suppl):1–29. 19. Michel JP, Pils K, Sieber C. Commentary on Kane’s paper: ‘‘Geriatrics at the crossroads. ’’ J Gerontol Med Sci. 2002;57A:M812–M813. 20. Proulx K, Jacelon C. Dying with dignity: the good patient versus the good death. Am J Hosp Palliat Care. 2004;21:116–120.
Bifidobacterial Diversity in Human Feces Detected by Genus-Specific PCR and Denaturing Gradient Gel Electrophoresis

ABSTRACT We describe the development and validation of a method for the qualitative analysis of complex bifidobacterial communities based on PCR and denaturing gradient gel electrophoresis (DGGE). Bifidobacterium genus-specific primers were used to amplify an approximately 520-bp fragment from the 16S ribosomal DNA (rDNA), and the fragments were separated in a sequence-specific manner in DGGE. PCR products of the same length from different bifidobacterial species showed good separation upon DGGE. DGGE of fecal 16S rDNA amplicons from five adult individuals showed host-specific populations of bifidobacteria that were stable over a period of 4 weeks. Sequencing of fecal amplicons resulted in Bifidobacterium-like sequences, confirming that the profiles indeed represent the bifidobacterial population of feces. Bifidobacterium adolescentis was found to be the most common species in feces of the human adult subjects in this study. The methodological approach revealed intragenomic 16S rDNA heterogeneity in the type strain of B. adolescentis, E-981074. The strain was found to harbor five copies of 16S rDNA, two of which were sequenced. The two 16S rDNA sequences of B. adolescentis E-981074T exhibited microheterogeneity differing in eight positions over almost the total length of the gene.
Silent celiac disease in a cohort of healthy adults

Background: Recent studies suggest that celiac disease (CD) is common in many developing countries. Because the disease may be under diagnosed in Cuba, we studied the presence of the disease in a group of apparently healthy adult. Aims/hypothesis: It was to assess for the first time, the presence of silent CD in a cohort of healthy Cuban adults individuals and to evaluate the tools for diagnosis of CD in this group. Methods: A total of 200 healthy Cuban adult from Havana City were evaluated. Tissue transglutaminase antibodies (tTGA) were determined by one-step immunochromatographic assay and by commercial ELISA kit. CD specific human leukocyte antigen (HLA) typing was performed by polymerase chain reaction amplification, using sequence-specific primers. In the subject positive for tTGA, the CD was confirmed by intestinal biopsy. Results: From the 200 studied individuals, only one subject was identified as positive by both assays, being submitted to duodenal biopsy. Morphological changes consistent with CD were found and also supported by HLA-DQ2 (HLA-DQA1*0501-DQB1*02). In the follow-up after one year, histological recovery was assessed by a second intestinal biopsy and the serological marker became negative. Conclusions: This study confirms the existence of silent CD among healthy adult in Cuba and highlights the importance of mass screening for this disease among them. The one-step immunochromatographic assay is a good tool for this purpose.
Multicenter Comparison Trial of DNA Extraction Methods and PCR Assays for Detection of Chlamydia pneumoniae in Endarterectomy Specimens

ABSTRACT The reported rate of detection of Chlamydia pneumoniaeDNA within atherosclerotic lesions by PCR varies between 0 and 100%. In this study, identical sets of coded experimental atheroma samples (n = 15) and spiked controls (n = 5) were analyzed by 16 test methods in nine centers by means of PCR. The positive controls were correctly identified to levels of 1, 0.1, and 0.01 inclusion bodies of C. pneumoniae/ml of tissue homogenate by 16 (100%), 11 (69%), and 3 (19%) of the test methods, respectively. Three out of 16 negative controls (19%) were rated positive. Positivity rates for atheroma samples varied between 0 and 60% for the different test methods, with the maximum concordant result for positivity being only 25% for one carotid artery sample. There was no consistent pattern of positive results among the various laboratories, and there was no correlation between the detection rates and the sensitivity of the assay used.
QUB at SemEval-2017 Task 6: Cascaded Imbalanced Classification for Humor Analysis in Twitter

This paper presents our submission to SemEval-2017 Task 6: #HashtagWars: Learning a Sense of Humor. There are two subtasks: A. Pairwise Comparison, and B. Semi-Ranking. Our assumption is that the distribution of humorous and non-humorous texts in real life language is naturally imbalanced. Using Naïve Bayes Multinomial with standard text-representation features, we approached Subtask B as a sequence of imbalanced classification problems, and optimized our system per the macro-average recall. Subtask A was then solved via the Semi-Ranking results. On the final test, our system was ranked 10th for Subtask A, and 3rd for Subtask B.