Miracle-dz/UniFAR-FTUs huggingface dataset:
Chemical Components and Bioactivities of Rhodiola rosea

Rhodiola rosea is a perennial plant at high altitudes in the Arctic and mountainous regions throughout Europe and Asia. It contains various active compounds e.g. phenylpropanoids, phenylethanol derivatives, flavanoids, monoterpenes, triterpenes, phenolic acids, and essential oils. Salidroside and tyrosol are the major bioactive constituents in Rhodiola rosea. Traditionally, Rhodiola rosea is used for the treatment of various ailments like altitude sickness, fatigue, depression, anemia, impotence, infections gastrointestinal ailments, etc. The modern pharmacological studies and clinical trials have demonstrated that this plant possesses anti-fatigue, antioxidant, anti-hypoxic, antidepressive, anti-anxiety, antimicrobial, antiviral, anti-inflammatory, anticancer, and immunomodulatory activities. This review summarizes current knowledge about chemical components and bioactivities of Rhodiola rosea.
Extracting Prototypical Facial Images from Exemplars

A computer graphic method for extracting a natural image of an individual's facial prototype, or average appearance, from a number of different images of that individual is presented. The process improves upon previous photographic and computational techniques. Synthesis of a person's average expression and pose from a sample of images is derived in an automatic and quantitative way. Possible uses of composite faces produced in this manner in psychological investigations of facial qualities (eg attractiveness) and in applied areas such as telecommunication are pointed out.
Solving the Orienteering Problem through Branch-and-Cut

In the Orienteering Problem (OP), we are given an undirected graph with edge weights and node prizes. The problem calls for a simple cycle whose total edge weight does not exceed a given threshold, while visiting a subset of nodes with maximum total prize. This NP-hard problem arises in routing and scheduling applications. We describe a branch-and-cut algorithm for finding an optimal OP solution. The algorithm is based on several families of valid inequalities. We also introduce a family of cuts, called conditional cuts, which can cut off the optimal OP solution, and propose an effective way to use them within the overall branch-and-cut framework. Exact and heuristic separation algorithms are described, as well as heuristic procedures to produce near-optimal OP solutions. An extensive computational analysis on several classes of both real-world and random instances is reported. The algorithm proved to be able to solve to optimality large-scale instances involving up to 500 nodes, within acceptable computing time. This compares favorably with previous published methods.
The Application of Ant Colony Optimization Technique (ACOT) for Employees Selection and Training

In this paper, ACOT was provided to advise for employees in selecting the Training Courses (TCs). The courses planning process needs to abide the company's policies regarding training hours and costs. In order to avoid the courses of an employee are confined to only one or two areas, we stipulate that the selected TCs cover three or more areas. This paper uses Ant Colony Optimization (ACO) algorithm to generate packages of TCs for individual employees with the maximization of utility (costs * hours) as the objective function values. Moreover, we also use an enumerate algorithm to verify the effectiveness and efficiency of our ACO algorithm. The two measurements are related to the solution quality and run time required by our algorithm.
3D visualization of the geographical & organizational structure of the grid

Enhanced and interactive visualization techniques are the key issues in improving the ability of users to comprehend and work with the large data sets. Various techniques have been used in the past incorporating different media and are applied to a wide range of application domains. In particular, 3D data representation often provides a more enhanced and intuitive user approach than the two dimensional approach. In this paper, we discuss several data visualization techniques with an emphasis on hierarchical data structures. We present a case study involving the implementation of a Web based application enabling the 3D visual access to grid network monitoring data. Geographically distributed computing nodes are arranged into "farms", which further contains a number of the organizationally distributed "clusters". The implemented visualization incorporates a geographical presentation of farms on a 3D model of the Earth and compares two tree-based techniques for the visualization of hierarchically organized clusters and nodes. We discuss the technology used to implement such an application and the achieved user benefits in terms of an enhanced display.
A Unique Substrate Binding Mode Discriminates Membrane Type-1 Matrix Metalloproteinase from Other Matrix Metalloproteinases*

In our study, we characterized the substrate recognition properties of membrane type-1 matrix metalloproteinase (MT1-MMP; also known as MMP-14), a key enzyme in tumor cell invasion and metastasis. A panel of optimal peptide substrates for MT1-MMP was identified using substrate phage display. The substrates can be segregated into four groups based on their degree of selectivity for MT1-MMP. Substrates with poor selectivity for MT1-MMP are comprised predominately of the Pro-X-X-↓-X Hy motif that is recognized by a number of MMPs. Highly selective substrates lack the characteristic Pro at the P3 position; instead they contain an Arg at the P4 position. This P4Arg is essential for efficient hydrolysis and for selectivity for MT1-MMP. Molecular modeling indicates that the selective substrates adopt a linear conformation that extends along the entire catalytic pocket of MT1-MMP, whereas non-selective substrates are kinked at the conserved P3 Pro residue. Importantly, the selective substrates can be made non-selective by insertion of a proline kink at P3, without significantly reducing overallk cat/K m values. Altogether the study provides a structural basis for selective and non-selective substrate recognition by MT1-MMP. The findings in this report are likely to explain several aspects of MT1-MMP biology.
Quantitative Analysis of Herpes Simplex Virus Reactivation In Vivo Demonstrates that Reactivation in the Nervous System Is Not Inhibited at Early Times Postinoculation

ABSTRACT Recent studies utilizing an ex vivo mouse model of herpes simplex virus (HSV) reactivation have led to the hypothesis that, under physiologic conditions inducing viral reactivation, the immune cells within the infected ganglion block the viral replication cycle and maintain the viral genome in a latent state. One prediction from the ex vivo study is that reactivation in ganglia in vivo would be inhibited at early times postinoculation, when the numbers of inflammatory cells in the ganglia are greatest. To distinguish between an effect of the immune infiltrates on (i) infectious virus produced and/or recovered in the ganglion and (ii) the number of neurons undergoing lytic transcriptional activity (reactivating), an assay to quantify the number of neurons expressing lytic viral protein in ganglia in vivo was developed. Infectious virus and HSV protein-positive neurons were quantified from days 9 through 240 postinoculation in latently infected trigeminal ganglia before and at 22 h after hyperthermic-stress-induced reactivation. Significant increases in the amount of virus and the number of positive neurons were detected poststress in ganglia at all times examined. Unexpectedly, the greatest levels of reactivation occurred at the times examined most proximal to inoculation. Acyclovir was utilized to stop residual acute-phase virus production, and this treatment did not reduce the level of reactivation on day 14. Thus, the virus measured after induction was a product of reactivation. These data indicate that, in contrast to observations in the ex vivo model, immune cells in the ganglia during the resolution of acute infection do not inhibit reactivation of the virus in ganglia in vivo.
Maternal stress affects postnatal growth and the pituitary expression of prolactin in mouse offspring

Maternal stress exerts long‐lasting psychiatric and somatic on offspring, which persist into adulthood. However, the effect of maternal stress on the postnatal growth of pups has not been widely reported. In this study, we found that maternal immobilization stress (IS) during lactation resulted in low body weight of male mouse offspring, which persisted after weaning. Despite free access to chow, IS induced maternal malnutrition and decreased the serum insulin‐like growth factor‐1 (IGF‐1) levels in the mothers and in the pups. mRNA expression analysis of anterior pituitary hormones in the pups revealed that growth hormone (GH) and prolactin (PRL), but no other hormones, were decreased by IS. Expression of the pituitary transcription factor PIT1 and isoforms of PITX2, which are essential for the development and function of GH‐producing somatotropes and PRL‐producing lactotropes, was decreased, whereas that of PROP1, which is critical for the earlier stages of pituitary development, was unchanged. Immunohistochemistry also showed a decrease in pituitary PRL protein expression. These results suggest that stress in a postpartum mother has persistent effects on the body weight of the offspring. Reduced PRL expression in the offspring's pituitary gland may play a role in these effects. © 2010 Wiley‐Liss, Inc.
A Schedule-based Multi-channel MAC Protocol for Wireless Sensor Networks

Due to the half-duplex property of the sensor radio and the broadcast nature of wireless medium, limited bandwidth remains a pressing issue for wireless sensor networks (WSNs). The design of multi-channel MAC protocols has attracted the interest of many researchers as a cost effective solution to meet the higher bandwidth demand for the limited bandwidth in WSN. In this paper, we present a scheduled-based multi-channel MAC protocol to improve network performance. In our protocol, each receiving node selects (schedules) some timeslot(s), in which it may receive data from the intending sender(s). The timeslot selection is done in a conflict free manner, where a node avoids the slots that are already selected by others in its interference range. To minimize the conflicts during timeslot selection, we propose a unique solution by splitting the neighboring nodes into different groups, where nodes of a group may select the slots allocated to that group only. We demonstrate the effectiveness of our approach thorough simulations in terms of performance parameters such as aggregate throughput, packet delivery ratio, end-to-end delay, and energy consumption.
A new construction of identity-based group signature

Identity-based (simply ID-based) public key cryptosystem allows the user to use his identity as the public key, which can be a good alternative for certificate-based public key setting. Group signature allows any member of a group to sign on behalf of the group without revealing his identity. A complete ID-based group signature scheme was proposed in ACISP’06. However, it was very impractical. In this paper, we give a construction of identity-based group signatures. Then, we construct an efficient ID-based group signature scheme. We also show that the group signature scheme is provably secure in the random oracle model.
A Comparative Study of Three English Translations of Yasin Surah Regarding Vinay and Darbelnet Strategies

Over the past few years, the Persian and English translations of Quran have been studied from different standpointsThroughout the centuries, Muslim and non-Muslim translators have been very concerned to convey the meaning ofthe Quran into languages other than Arabic. The holy Quran is a divine book and its translation into other languagesmust be done meticulously. In this regard, Persian and English translation of one of the surahs of this magnificentbook was selected to be compared. the present study has gone through the investigation of the Persian translation ofone of the surahs of this holy book “Yasin” by Dr. Elahi Ghomshei (1361) and its English translation by threefamous translators Yusuf Ali (2000), Pickthall (1930) and Sarwar (2011) to see discrepancies. Also, this study triesto find out the unit of translation and classify different kinds of Vinay and Darbelnet’s procedures used by theEnglish translators.
ldentification of a Sequence-Specific DNA Binding Factor Required for Transcription of the Barley Chloroplast Blue Light-Responsive psjbD-psbC Promoter

The plastid gene psbD encodes the photosystem II reaction center chlorophyll protein D2. psbD is located in a complex operon that includes psbC, psbK, psbl, orf62, and tmG. The operon is transcribed from at least three different promoters. One of the psbD promoters is differentially activated when plants are exposed to blue light. In this study, the psbD blue light-responsive promoter was accurately transcribed in vitro in high-salt extracts of barley plastids. Transcription required supercoiled templates and was inhibited by tagetitoxin, an inhibitor of plastid transcription. Escherichia co l i RNA polymerase did not recognize the psbD light-responsive promoter wi th the same specificity as plastid RNA polymerase. Deletion analyses demonstrated that sequences between -39 and -68, upstream of the transcription initiation site, were required for transcription of the psbD blue light-responsive promoter. This DNA region is highly conserved among plant species and contains multiple AAG sequences. Gel shift assays and DNase I footprinting experiments demonstrated that the AAG-rich DNA sequence interacts with a sequence-specific DNA binding factor termed AGF. Point mutations in the AAG c is element decreased binding of AGF and inhibited transcription from the psbD light-responsive promoter. We concluded that AGF is an essential factor required for transcription of the psbD light-responsive promoter.
A minimally invasive management for abdominal compartment syndrome in severe acute pancreatitis

Three patients with severe acute pancreatitis (SAP) developed into overt abdominal compartment syndrome (ACS) and confirmed or suspected infection of necrotic tissue. We successfully treated these patients by minimally invasive decompression with the assist of laparoscope after the failures of intensive care treatments. This technique we report here may be another safe and effective management for ACS in SAP.
[Exercise and sports therapy for patients with head and neck tumors].

Important aspects in the aftercare of patients with cancer of head and neck can be realized by physical training in a sports group. The aftermath of operative therapy, e.g. loss of motion, imbalances of muscular activity or respiratory movements, can be reduced. The main importance of physical training in a group is the patient's reintegration in a social environment. Evaluating the quality of life of the individual patient we found that this method of psychosocial aftercare can improve subjective quality of life. Therefore, this conception of rehabilitation should not be missing in the aftercare of patients with malignant cancer.
Design of Accumulator Based 3-Weight Pattern Generation Using Kogge Stone Adder

Weighted sets consist of three weights ,namely 0,1,and 0.5 have been successfully use so far for test pattern generation, since they gives both low testing time and low consumed power. Since accumulators are generally found in current VLSI chips, this scheme can be effectively made to use drive down the hardware of BIST pattern generation, as well. From the execution results, it is proved that the testing power for the proposed method is reduced by a considerable percentage. In accumulators used the adder, if we RCA adder or CLA adder its consume the more power and required more gates . If we kogges stone adder its required less power and less gates. Comparisons with previously presented schemes indicate that the recommended scheme compares favorably regarding required hardware.
Prophage Contribution to Bacterial Population Dynamics

ABSTRACT Cocultures of Salmonella strains carrying or lacking specific prophages undergo swift composition changes as a result of phage-mediated killing of sensitive bacteria and lysogenic conversion of survivors. Thus, spontaneous prophage induction in a few lysogenic cells enhances the competitive fitness of the lysogen population as a whole, setting a selection regime that forces maintenance and spread of viral DNA. This is likely to account for the profusion of prophage sequences in bacterial genomes and may contribute to the evolutionary success of certain phylogenetic lineages.
Mutations in the Pho2 (Bas2) Transcription Factor That Differentially Affect Activation with Its Partner Proteins Bas1, Pho4, and Swi5*

The yeast PHO2 gene encodes a homeodomain protein that exemplifies combinatorial control in transcriptional activation. Pho2 alone binds DNA in vitrowith low affinity, but in vivo it activates transcription with at least three disparate DNA-binding proteins: the zinc finger protein Swi5, the helix-loop-helix factor Pho4, and Bas1, an myb-like activator. Pho2 + Swi5 activates HO, Pho2 + Pho4 activatesPHO5, and Pho2 + Bas1 activates genes in the purine and histidine biosynthesis pathways. We have conducted a genetic screen and identified 23 single amino acid substitutions in Pho2 that differentially affect its ability to activate its specific target genes. Analysis of the mutations suggests that the central portion of Pho2 serves as protein-protein interactive surface, with a requirement for distinct amino acids for each partner protein.
Basal Cerebral Metabolism May Modulate the Cognitive Effects of Aβ in Mild Cognitive Impairment: An Example of Brain Reserve

Inverse correlations between amyloid-β (Aβ) load measured by Pittsburgh Compound-B (PiB) positron emission tomography (PET) and cerebral metabolism using [18F]fluoro-2-deoxy-d-glucose (FDG) in Alzheimer's disease (AD) patients, suggest local Aβ-induced metabolic insults. However, this relationship has not been well studied in mild cognitive impairment (MCI) or amyloid-positive controls. Here, we explored associations of Aβ deposition with metabolism via both region-of-interest-based and voxel-based analyses in amyloid-positive control subjects and patients with MCI or AD. Metabolism in parietal and precuneus cortices of AD patients was negatively correlated with PiB retention locally, and more distantly with PiB retention in frontal cortex. In amyloid-positive controls, no clear patterns in correlations were observed. In MCI patients, there were essentially no significant, negative correlations, but there were frequent significant positive correlations between metabolism and PiB retention. Metabolism in anterior cingulate showed positive correlations with PiB in most brain areas in MCI, and metabolism and PiB retention were positively correlated locally in precuneus/parietal cortex. However, there was no significant increase in metabolism in MCI compared to age-matched controls, negating the possibility that Aβ deposition directly caused reactive hypermetabolism. This suggests that, in MCI, higher basal metabolism could either be exacerbating Aβ deposition or increasing the level of Aβ necessary for cognitive impairment sufficient for the clinical diagnosis of AD. Only after extensive Aβ deposition has been present for longer periods of time does Aβ become the driving force for decreased metabolism in clinical AD and, only in more vulnerable brain regions such as parietal and precuneus cortices.
The influence of vitamins and trace element supplements on the stability of the pre‐corneal tear film

Abstract. The tear stability af 60 normal healthy subjects was measured and repeated 10 days later. Using a double‐blind protocol, during the interim period 2/3 of the subjects (the treatment groups) took a commercially available daily dietary supplement and the remaining 1/3 acted as controls. The recommended daily dose was applied to the treatment groups. 20 of the treatment group took a daily dietary supplement of a mixture consisting of vitamins (e.g. A, B1, B2, B6, E) and trace elements (e.g. calsium, iron, manganese), the other 20 took purely vitamin C tablets. The tear stability of both treated groups increased, however, the multi‐vitamin and trace element group demonstrated the more consistent and individually predictable improvement. Within this group, the characteristics of the regression line correlating the initial mean (x) and final mean (y) tear stabilities were, y = 5.94+1.02x. The tear stability of the control group individuals did not significantly change.
By-catch composition of the Patagonian scallop fishery: the fishes

An inventory of 24 fish species incidentally caught by the Patagonian scallop fleet in the SW Atlantic Ocean is provided for the first time. The most frequent species were Psammobatis spp. (81.4%), Bathyraja brachyurops (75.1%), B. macloviana (73.5%), Patagonotothen ramsayi (66.1%), Merluccius hubbsi (53.7%) and B. albomaculata (50.3%). Many of the recorded chondrichthyes are considered vulnerable or endangered species. The number of taxa (fishes + invertebrates) that conforms the by-catch of the fishery was increased and updated to nearly 200 species.
The Pichia pastoris peroxisomal protein PAS8p is the receptor for the C‐terminal tripeptide peroxisomal targeting signal.

The peroxisomal targeting signal 1 (PTS1), consisting of a C‐terminal tripeptide (SKL and variants), directs polypeptides to the peroxisome matrix in evolutionarily diverse organisms. Previous studies in the methylotrophic yeast Pichia pastoris identified a 68 kDa protein, PAS8p, as a potential component of the PTS1 import machinery. We now report several new properties of this molecule which, taken together, show that it is the peroxisomal PTS1 receptor. (i) PAS8p is localized to and tightly associated with the cytoplasmic side of the peroxisomal membrane, (ii) peroxisomes of wild‐type, but not of pas8 delta (null) mutant, P.pastoris cells bind a PTS1‐containing peptide (CRYHLKPLQSKL), (iii) CRYHLKPLQSKL can be cross‐linked to PAS8p after binding at the peroxisome membrane and (iv) purified PAS8p binds CRYHLKPLQSKL with high affinity (nanomolar dissociation constant). In addition, the tetratricopeptide repeat (TPR) domain of PAS8p is identified as the PTS1 binding region.
The effect of smoking on physiological decongestion of the nasal mucosa in human.

BACKGROUND Exercise is known to decongest the nasal mucosa which results in increased nasal patency. In a recent study it was suggested that smoking might influence the effect of exercise on the nasal mucosa. This implies that smoking may cause neurological damage to the normal nasal physiology, which has not previously been shown. The aim of this study was to investigate whether there was a difference in nasal mucosal reaction to exercise between smokers and non-smokers. METHODOLOGY Forty-two smokers and non-smokers underwent acoustic rhinometry to register nasal geometry before and after cycling on an ergometer cycle. A structured interview was used for questions about smoking habits and airway symptoms. RESULTS Both smokers and non-smokers had a significant increase in MCA (minimal cross-section area) and total nasal volume after exercise. There was no statistical significant difference between smokers and non-smokers. CONCLUSIONS Smoking does not seem to affect the normal physiological decongestion of the nasal mucosa after exercise.