Miracle-dz/UniFAR-FTUs huggingface dataset:
Information-Assisted Density Peak Index for Hyperspectral Band Selection

Band selection has become an effective method to reduce hyperspectral dimensionality. In this letter, an information-assisted density peak index (IaDPI) is proposed to prioritize the bands. Based on a clustering method by finding density peaks, IaDPI introduces the intraband information entropy into the local density and intercluster distance to ensure cluster centers with a high quality. Also, the band distance is integrated with channel proximity to control the compactness of local density. Owing to the intraband entropy and the interband weighted dissimilarity, the selected band set with top-ranked IaDPI scores can hold high local density, clear global distinction, and good informative quality. Experimental results on real hyperspectral data indicate the advantages of the proposed IaDPI in good selection quality, robust noise immunity, and high classification accuracy.
Ca2+-dependent Cell Signaling through Calmodulin-activated Protein Phosphatase and Protein Kinases Minireview Series*

first showed that extracellu- lar Ca 2 1 was necessary for muscle contractions (1). Research the has revealed that intracellular Ca 2 1 mediates a large number of cellular responses with the high affinity and specificity required for a regulatory second messenger. The identi-fication and biochemical characterization of Ca 2 1 -dependent signaling pathways were stimulated by the pioneering proposal that Ca 2 1 acts by binding to specific intracellular proteins, which may be considered Ca 2 1 receptors (2). The class of proteins that binds Ca 2 1 with high affinity and specificity now includes hundreds of members (3). Nevertheless, a large proportion of studies focused on calmodulin because it was recognized as a regulator of many dif-ferent target enzymes (4). Calmodulin interactions with proteins are categorized into six distinct classes based on Ca 2 1 -independent and -dependent modes of binding and regulation (5). Complemen- tary structural features in both calmodulin and respective target proteins allow diverse and discrete modes of effector regulation. Biophysical studies of Ca 2 1 binding to calmodulin and Ca 2 1 / calmodulin binding to peptide targets from Ca 2 1 /calmodulin-de-pendent protein kinases have provided insights into how calmod- ulin functions (5, 6). Calmodulin has four Ca 2 1 -binding sites with two in a globular N-terminal domain separated by a flexible a -helix from a C-terminal globular domain containing the other two Ca 2 1 binding sites. In the presence of Ca 2 1 each domain adopts an open conformation exposing a hydrophobic pocket that renders cal- modulin functional for binding to target sequences. The process of complex formation includes sequential interactions between the C-terminal hydrophobic pocket with a hydrophobic residue in the target N-terminal sequence
Clinical Trial Accrual Targeting Genomic Alterations After Next-Generation Sequencing at a Non-National Cancer Institute-Designated Cancer Program.

PURPOSE Successful clinical trial accrual targeting uncommon genomic alterations will require broad national participation from both National Cancer Institute (NCI)-designated comprehensive cancer centers and community cancer programs. This report describes the initial experience with clinical trial accrual after next-generation sequencing (NGS) from three affiliated non-NCI-designated cancer programs. MATERIALS AND METHODS Clinical trial participation was reviewed after enrollment of the first 200 patients undergoing comprehensive genomic profiling by NGS as part of an institutional intuitional review board-approved protocol at three affiliated hospitals in Rhode Island and was compared with published experience from NCI-designated cancer centers. RESULTS Patient characteristics included a median age of 64 years, a median of two lines of prior therapy, and a predominance of GI carcinomas (58%). One hundred sixty-four of 200 patients (82%) had adequate tumor for NGS, 95% had genomic alterations identified, and 100% had variants of unknown significance. Fifteen of 164 patients (9.2%) enrolled in genotype-directed clinical trials, and three patients (1.8%) received commercially available targeted agents off clinical trials. The reasons for nonreceipt of NGS-directed therapy were no locally available matching trial (48.6%), ineligibility (33.6%) because of comorbidities or interim clinical deterioration, physician's choice of a different therapy (6.8%), or stable disease (11%). CONCLUSION This experience demonstrates that a program enrolling patients in specific targeted agent clinical trials after NGS can be implemented successfully outside of the NCI-designated cancer program network, with comparable accrual rates. This is important because targetable genes have rare mutation rates and clinical trial accrual after NGS is low.
Etude transversale et longitudinale des relations entre les environnements géographiques de vie et l'excès de poids et le risque cardiovasculaire

Face aux limites de la litterature internationale sur les disparites environnementales de prevalence d’obesite (focus sur le lieu de residence, etc.) et considerant le manque d’etudes empiriques realisees en France, nous nous sommes interesses tout d’abord aux relations entre, d’une part, les caracteristiques des environnements residentiels et professionnels et le secteur d’activite economique et, d’autre part, deux indicateurs d’exces de graisse corporelle : l’indice de masse grasse (IMG) et le pourcentage de masse grasse (%MG). Ensuite, nous avons compare les effets des secteurs d’activite economique sur plusieurs facteurs de risque cardiovasculaire. Finalement, a l’aide d’une etude longitudinale, nous avons evalue les liens entre les variables socio-economiques et l’evolution des parametres anthropometriques chez les participants de l’Etude RECORD. Parallelement a l’etude de ces relations, notre objectif methodologique etait d’explorer les biais d’attrition lies aux donnees manquantes dans les etudes longitudinales.Pour conclure, nous avons pu par ces travaux empiriques mettre en evidence des effets des caracteristiques individuelles, de l’environnement residentiel, et des secteurs d’activite economique sur l’accumulation de la masse grasse corporelle ainsi que sur les facteurs de risque cardiovasculaire. En ce qui concerne le volet methodologique de ce travail, d’une part nous avons ete en mesure de tenir compte dans les analyses de l’environnement geographique de residence communement pris en compte. D’autre part, nous demarquant d’une litterature sur les determinants sociaux de l’obesite essentiellement transversale, nous montrons que selon le mecanisme des donnees manquantes, les methodes statistiques communement utilisees ne permettent pas de contourner les biais potentiels induits par l’attrition dans les analyses longitudinales.
Characterization of copy number‐stable regions in the human genome

In the past few years the number of copy number variants (CNVs) identified in the human genome has increased significantly, but our understanding of the functional impact of CNVs is still limited. Clinically significant variations cannot easily be distinguished from benign, complicating interpretation of patient data. Multiple studies have focused on analysis of regions that vary in copy number in specific disorders. Here we use the opposite strategy and focus our analysis on regions that never seem to vary in the general population, hypothesizing that these are copy number stable because variations within them are deleterious. Our results show that copy number stable regions are characterized by correlation with a number of genomic features, allowing us to define a list of genomic regions that are dosage sensitive in humans. We find that these dosage‐sensitive regions show significant overlap with de novo CNVs identified in patients with intellectual disability or autism. There is also a significant association between copy number stable regions and rare inherited variants in autism patients, but not in controls. Based on this predictive power, we propose that copy number stable regions can be used to complement maps of known CNVs to facilitate interpretation of patient data. Hum Mutat 32:1–9, 2011. © 2011 Wiley‐Liss, Inc.
A documental database query language

This work presents a natural language based technique to build user interfaces to query document databases through the web. We call such technique Bounded Natural Language (BNL). Interfaces based on BNL are useful to query document databases containing only structured data, containing only text or containing both of them. That is, the underlying formalism of BNL can integrate restrictions over structured and non-structured data (as text). Interfaces using BNL can be programmed ad hoc for any document database but in this paper we present a system with an ontology based architecture in which the user interface is automatically generated by a software module (User Interface Generator) capable of reading and following the ontology. This ontology is a conceptualization of the database model, which uses a label in natural language for any concept in the ontology. Each label represents the usual name for a concept in the real world.The ontology includes general concepts useful when the user is interested in documents in any corpus in the database, and specific concepts useful when the user is interested in a specific corpus. That is, databases can store one or more corpus of documents and queries can be issued either over the whole database or over a specific corpus.The ontology guides the execution of the User Interface Generator and other software modules in such a way that any change in the database does not imply making changes in the program code, because the whole system runs following the ontology. That is, if a modification in the database schema occurs, only the ontology must be changed and the User Interface Generator will produce a new and different user interface adapted to the new database.
X Chromosome Dosage and the Response to Cerebral Ischemia

Gonadal hormones contribute to ischemic neuroprotection, but cannot fully explain the observed sexual dimorphism in stroke outcomes seen during life stages with low sex steroid hormones. Sex chromosomal complement (XX in females; XY in males) may also contribute to ischemic sexual dimorphism. A transient middle cerebral artery occlusion model was used to investigate the role of X chromosome dosage in female XX and XO littermates of two mouse strains (Paf and EdaTa). Cohorts of XX and XO gonadally intact, ovariectomized, and ovariectomized females supplemented with estrogen were examined. Infarct sizes were equivalent between ovariectomized XX and XO mice, between intact XX and XO mice, and between estrogen-supplemented ovariectomized XX and XO mice. This is the first study to investigate the role of sex chromosome dosage in the response to cerebral ischemia. Neither the number of X chromosomes nor the parent of origin of the remaining X chromosome had a significant effect on the degree of cerebral infarction after experimental stroke in adult female mice. Estrogen was protective against cerebral ischemia in both XX and XO mice.
Performance study of wireless universal serial bus transmission system

This study is evaluated the performance of wireless universal serial bus (WUSB) transmission system by Wimedia alliance defined. WUSB adopts the multi-band orthogonal frequency division multiplexing (MB-OFDM) ultra-wideband (UWB) technology to raise the transmission data rate up to 480Mbps. An experimental WUSB system is setup to demonstrate its performance for high data rate and excellent packet error rate (PER) at various short distances on free space.
Vibration‐induced neuropathy among forestry workers

ABSTRACT – The neurological findings of 217 forestry workers were evaluated during a compulsory annual health examination. Vibration detection thresholds were determined for the left hand and foot. The handgrip forces were measured for both hands. A reduction in the vibration detection threshold or handgrip force was not associated with clinical neuropathy. Polyneuropathy was found in 4% of the lumberjacks whereas neuropathy restricted to the arms was found in 7.5 % of the lumberjacks. The neuropathic findings were not linked with alcohol consumption but were associated with a history of numbness in the hands and diminished muscle force. The findings support the concept that local vibration can cause neuropathy in the arms, but the mechanism of vibration‐induced neuropathy still remains uncertain.
On stability margins assessment for electrical power systems

The problems of the distributed generation integration into the main network related to the dynamic interaction of the main network generators with large inertia with distributed generation which have a small inertia, are considered. As a result of this interaction, there are dangerous weakly stable oscillations, which can lead to the breakdown of consumers technological equipment, or electrical equipment in the main network. Modal analysis is the main method of the dangerous oscillations monitoring in the world. The method involves calculating the eigenvalues (modes) of the system's dynamics matrix and determining the eigenvalue with the maximum real part. The subgramians method allows to calculate the current energy value of the weakly stable modes accumulated in their group, which is the basis of a new technology for the stability margins estimating based on energy criteria. The main attention is paid to modal analysis and the method of gramians, their comparison and description of the hybrid method of small signal stability analysis are given.
A hybrid multidimensional Algorithm for network-aware resource scheduling in clouds and grids

Today's e-Infrastructures are deployed to enable easy and secure access to heterogeneous resources (e.g., instrument, computing and storage elements) by exploiting cloud and grid technologies. Since e-Science applications are usually characterized by huge data transfers, user interactivity and high computational loads, the selection and allocation of cloud or grid resources dramatically affect their performance. Starting from a previous work by the same authors, this paper proposes a new distributed resource allocation algorithm, referred to as MRA3D-H, capable of handling multiple resource requirements for jobs/tasks that arrive to the computing environment of the e-Infrastructure. More specifically, MRA3D-H aims at finding a trade-off between execution time and cost of data-intensive applications by taking into account performance parameters at system and network levels as well as the economic cost of computational resources. Simulations have been carried out to compare the performance of MRA3D-H with other resource allocation algorithms in the DORII project environment.
The phytotoxin fusicoccin, a selective stabilizer of 14‐3‐3 interactions?

Summary The study of the structure and dynamics of protein–protein interaction networks has become overwhelming in all biological systems. Most of the biological events are the consequence of several protein–protein interactions finely regulated by covalent modifications and physiological effectors. Moreover, several studies have shown that the complex interactome responsible for the progress and control of vital processes is disturbed in diseases. Besides the basic information on the mechanisms involved in the processes driven by protein–protein interactions, it appears nowadays extremely challenging to study possible regulators of the lifespan of protein networks. Small molecules able to stabilize or to inhibit protein complexes could easily find applications as potential innovative drugs. In this article, we hypothesize that a natural product, the fungal phytotoxin fusicoccin, can play a role as a stabilizer of interactions between 14‐3‐3 proteins and specific natural targets. A very specific stabilizer molecule is the ideal starting point for the development of a family of structurally related drugs able to selectively tune 14‐3‐3 interaction with their targets. © 2013 IUBMB Life, 65(6):513–517, 2013
Gas-chromatographic determination of theophylline in human serum and saliva.

We report a gas-chromatographic procedure for routine determination of the bronchodilator, theophylline (1,3-dimethylxanthine), in serum and saliva. Volatile butyl derivatives for gas chromatography were prepared by the method of Greeley [ Clln. Chem. 20, 192 (1974)], with butyliodide as the alkylating agent. Substances that interfere in the classical determination of theophylline, such as theobromine (3,7-dimethylxanthine) and phenobarbital, are well separated from theophylline by the gas-chromatographic procedure and can be quantitated if desired. It is possible to determine 1 µg of theophylline in 1 ml of serum or saliva. Between-run precision for 15 µg/ml samples was 5.3%. This determination is useful in assessing patient compliance with medication instructions and in adjusting dosage schedules of theophylline in patients attending a pediatric allergy clinic.
Time-Series Research: Some Comments on Design Methodology for Research in Learning Disabilities

This paper suggests that time-series design methodology provides a useful paradigm in which to conduct research in the learning disabilities field. It includes a review of some specific characteristics of time-series methodology that could usefully advance understanding of learning problems through applied research. These features include establishing experimental relations between variables in single cases, evaluating change over time, providing options to conventional research methodology, encouraging research in applied settings, and specification of learner characteristics. The paper concludes with a discussion of the relations between time-series and conventional experimental research strategies for future research in the learning disabilities field.
Divergent selection and phenotypic plasticity during incipient speciation in Lake Victoria cichlid fish

Divergent selection acting on several different traits that cause multidimensional shifts are supposed to promote speciation, but the outcome of this process is highly dependent on the balance between the strength of selection vs. gene flow. Here, we studied a pair of sister species of Lake Victoria cichlids at a location where they hybridize and tested the hypothesis that divergent selection acting on several traits can maintain phenotypic differentiation despite gene flow. To explore the possible role of selection we tested for correlations between phenotypes and environment and compared phenotypic divergence (PST) with that based on neutral markers (FST). We found indications for disruptive selection acting on male breeding colour and divergent selection acting on several morphological traits. By performing common garden experiments we also separated the environmental and heritable components of divergence and found evidence for phenotypic plasticity in some morphological traits contributing to species differences.
T-peak to T-end Interval Predicts Appropriate Shocks in Patients with Heart Failure Undergoing Implantable Cardioverter Defibrillator Implantation for Primary Prophylaxis.

BACKGROUND T-wave peak to T-wave end interval (Tp-e) correlates with dispersion of ventricular repolarization. The purpose of this study was to assess the ability of Tp-e to predict appropriate implantable cardioverter defibrillator (ICD) shocks and all-cause mortality in patients who underwent ICD implantation for primary prophylaxis. METHODS Two hundred twenty-eight patients with left ventricular ejection fraction ≤35% and an ICD implanted were followed-up prospectively. Patients divided into two subgroups according to presence of appropriate ICD shocks (Group 1: 112 patients with ICD shocks, Group 2: 116 patients without shocks). End points were appropriate ICD therapy due to ventricular tachycardia (VT)/ventricular fibrillation (VF), death, and a combined end point of VT/VF or death. RESULTS During a mean follow-up of 22.3 ± 7.7 months, appropriate ICD shocks were observed in 112 of 228 patients (49.1%). The mean duration of the Tp-e Group 1 was significantly longer than Group 2 (115.3 ± 22.2 vs 104.7 ± 20.2 ms, P < 0.001). Ischemic etiology and Tp-e duration were found to be independent predictors of ICD therapy. When the patients were divided into two groups based on Tp-e interval, there was no significant difference regarding the mortality between groups (21.2% vs 21.8%, P: 0.186). However, appropriate ICD shocks due to VT/VF (37.5% vs 58.8%, P < 0.001) and combined end point (39.4% vs 64.5%, P: 0.002) were significantly higher in patients with longer Tp-e group. CONCLUSIONS Tp-e interval independently predicts appropriate ICD shocks in patients with systolic dysfunction and ICDs implanted for primary prevention.
Virtualizing Network Processors

This paper considers the problem of virtualizing the resources of a network processor (NP) in order to allow multiple third-parties to execute their own virtual router software on a single physical router at the same time. Our broad interest is in designing such a router capable of supporting virtual networking. We discuss the issues and challenges involved in this virtualization, and then describe specific techniques for virtualizing both the control and data-plane processors on NPs. For Intel IXP NPs in particular, we present a dynamic, macro-based technique for virtualization that allows multiple virtual routers to run on multiple data plane processors (or micro-engines) while maintaining memory isolation and enforcing memory bandwidth allocations. Type of Report: Other Department of Computer Science & Engineering Washington University in St. Louis Campus Box 1045 St. Louis, MO 63130 ph: (314) 935-6160 Virtualizing Network Processors Ben Wun, Jonathan Turner, Patrick Crowley Dept. of Computer Science and Engineering Washington University in St. Louis, MO, 63130 bw6@arl.wustl.edu, jon.turner@wustl.edu, pcrowley@wustl.edu ABSTRACT This paper considers the problem of virtualizing the resources of a network processor (NP) in order to allow multiple third-parties to execute their own virtual router software on a single physical router at the same time. Our broad interest is in designing such a router capable of supporting virtual networking. We discuss the issues and challenges involved in this virtualization, and then describe specific techniques for virtualizing both the control and data-plane processors on NPs. For Intel IXP NPs in particular, we present a dynamic, macro-based technique for virtualization that allows multiple virtual routers to run on multiple data plane processors (or micro-engines) while maintaining memory isolation and enforcing memory bandwidth allocations. This paper considers the problem of virtualizing the resources of a network processor (NP) in order to allow multiple third-parties to execute their own virtual router software on a single physical router at the same time. Our broad interest is in designing such a router capable of supporting virtual networking. We discuss the issues and challenges involved in this virtualization, and then describe specific techniques for virtualizing both the control and data-plane processors on NPs. For Intel IXP NPs in particular, we present a dynamic, macro-based technique for virtualization that allows multiple virtual routers to run on multiple data plane processors (or micro-engines) while maintaining memory isolation and enforcing memory bandwidth allocations.