Miracle-dz/UniFAR-FTUs huggingface dataset:
Induced decision trees for case-based reasoning

The paper examines application of a machine learning technique, decision tree induction, to the development of CBR systems. The decision tree generated by the induction algorithm is generally used to create a set of rules for a traditional rule based system; however, it may be used to determine the weight (i.e., importance) of features for classification. This approach combines the flexibility of CBR systems with the machine learning ability to automatically derive decision criteria. We experimentally assess the tolerance of rule induction to noise and missing values and find it surprisingly resilient to poor quality training data. This bodes well for use of rule induction to allow the process of CBR system development to be more independent of expert judgement.
CMOS-compatible ehancement-mode GaN-on-Si MOS-HEMT with high breakdown voltage (930V) using thermal oxidation and TMAH wet etching

In this paper, we report for the first time, an enhancement-mode (E-mode) Al2O3/GaN metal-oxide-semiconductor high-electron-mobility-transistor (MOS-HEMT) using CMOS-compatible techniques including gate region local thermal oxidation and organic alkaline solution (TMAH) wet etching. The fabricated MOS-HEMT exhibits a high positive threshold voltage of +2.5 V, indicating complete pinch-off of the 2 dimensional electron gas (2DEG) channel. Maximum drain current of 250 mA/mm and an off-state breakdown voltage up to 930 V at a 0 V gate bias are observed for the fabricated device of LG = 2.0 μm and LGD = 14 μm, manifesting a low cost, highly repeatable CMOS compatible fabrication method of normally-off GaN-on-Si devices for power electronics applications.
“Propre.Ma” project: roadmap & preliminary results for grid-connected PV yields maps in Morocco

Sponsored by IRESEN for 3 years starting on February 2014, ”Propre.Ma” is a project carried by 20 higher education Moroccan institutions and one private company (RESING). “Propre.Ma” intends to draw a map of precise grid-connected PV DC yields for all Morocco with ground calibration in 20 different cities. “Propre.Ma” is developing its own metrology for this. In this paper we present the project roadmap and preliminary results.
A 2.5-10Gb/s CMOS transceiver with alternating edge sampling phase detection for loop characteristic stabilization

A 2.5 to 10 Gb/s CMOS transceiver in 0.18 /spl mu/m CMOS dissipates 540 mW from a 1.8 V supply with a BER better than 10/sup -12/. CDR loop characteristics are stabilized across various jitter environments with small hardware overhead using an alternating edge sampling phase detector.
Described Video Information and animation: a case study of Odd Job Jack

We assess the potential demand for video description technology to determine the viability of Description Video Information and Entertainment (DVIE) as a product for sighted viewers. Two forms of DVIE, with visuals and an audio-only version (original audio track plus DVIE), were produced for a television series, Odd Job Jack (OJJ). Sighted individuals from the target group (18-35 years) and from an older age group (65+) evaluated these different versions. Results showed that many people were fairly entertained by OJJ with DVIE. Those who enjoyed the show also indicated that they would be willing to pay a small amount to purchase an audio-only.
Effect of high-pressure pre-treatment on the enzymatic activity related to quality loss in frozen hake

Consumers demand for high quality food stuffs with no preservatives and with extended shelf-life, retaining the quality properties, led to the development of new processing technologies. One of those technologies, studied in this work, is High Pressure Processing (HPP), which has shown good results on fish shelf-life extension, with great importance in fish safety by inactivation of microbial load (mostly pathogenic microorganisms) in refrigerated fish, and inactivation of certain degradative enzymes, mainly in frozen fish. Fish products are usually stored under refrigeration or frozen to maintain their quality and safety patterns. However, there are still several reactions that cause fish degradation. For instance, even under frozen storage, enzymatic activity still occurs. According to the literature, HPP has shown to be a promising pretreatment to inhibit these enzymes and extend frozen fish-shelf-life. This work aimed to determine the effect of HPP (150 MPa for 2 minutes) and storage temperature (-10, -20 and -30 oC) on the quality of frozen hake muscle (Merluccius merluccius). It was verified that HPP resulted in a decrease of calpains activity (59 %) after 12 months of storage at -20 oC and maintained the activity of acid phosphatase, cathepsin B and calpains after 12 months at -30 oC Furthermore, the quantification of sulfhydryl (SH) groups indicated that the HP treatment results in higher SH content (increase up to 190%), as well as increased storage time (increase up to 120%), being this increase probably related with protein denaturation of fish muscle. This work presents relevant information concerning the employment of HP pretreatments to reduce enzymatic activity associated to quality loss in frozen European hake (Merluccius merluccius). This type of processing can so be of interest to enhance the quality preservation of frozen hake, as well as of other species.
Biosynthesis of Heparin/Heparan Sulfate

Glucuronyl C5-epimerases catalyze the conversion of d-glucuronic acid (GlcUA) tol-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans. An epimerase implicated in the generation of heparin/heparan sulfate was previously purified to homogeneity from bovine liver (Campbell, P., Hannesson, H. H., Sandbäck, D., Rodén, L., Lindahl, U., and Li, J.-p. (1994) J. Biol. Chem. 269, 26953–26958). The present report describes the molecular cloning and functional expression of the lung enzyme. The cloned enzyme contains 444 amino acid residues and has a molecular mass of 49,905 Da. N-terminal sequence analysis of the isolated liver enzyme showed this species to be a truncated form lacking a 73-residue N-terminal domain of the deduced amino acid sequence. The coding cDNA insert was cloned into a baculovirus expression vector and expressed in Sf9 insect cells. Cells infected with recombinant epimerase showed a 20–30-fold increase in enzyme activity, measured as release of 3H2O from a polysaccharide substrate containing C5-3H-labeled hexuronic acid units. Furthermore, incubation of the expressed protein with the appropriate (GlcUA-GlcNSO3) n substrate resulted in conversion of ∼20% of the GlcUA units into IdceA residues. Northern analysis implicated two epimerase transcripts in both bovine lung and liver tissues, a dominant ∼9-kilobase (kb) mRNA and a minor ∼5-kb species. Mouse mastocytoma cells showed only the ∼5-kb transcript. A comparison of the cloned epimerase with the enzymes catalyzing an analogous reaction in alginate biosynthesis revealed no apparent amino acid sequence similarity.
An adaptive recurrent radial basis function network tracking controller for a two-dimensional piezo-positioning stage

An adaptive recurrent radial basis function network (ARRBFN) tracking controller for a two-dimensional piezo-positioning stage is proposed in this study. First, a mathematical model that represents the dynamics of the two-dimensional piezo-positioning stage is proposed. In this model, a hysteresis friction force that describes the hysteresis behavior of one-dimensional motion is used; and a nonconstant stiffness with the cross-coupling dynamic due to the effect of bending of a lever mechanism in x and y axes also is included. Then, according to the proposed mathematical model, an ARRBFN tracking controller is proposed. In the proposed ARRBFN control system, a recurrent radial basis function network (RRBFN) with accurate approximation capability is used to approximate an unknown dynamic function. The adaptive learning algorithms that can learn the parameters of the RRBFN on line are derived using Lyapunov stability theorem. Moreover, a robust compensator is proposed to confront the uncertainties, including approximation error, optimal parameter vectors, higher-order terms in Taylor series. To relax the requirement of the value of the lumped uncertainty in the robust compensator, an adaptive law is investigated to estimate the lumped uncertainty. Using the proposed control scheme, the position tracking performance is substantially improved and the robustness to uncertainties, including hysteresis friction force and cross-coupling stiffness, can be obtained as well. The tracking performance and the robustness to external load of the proposed ARRBFN control system are illustrated by some experimental results.
Multi-Agent Recommendation System in Internet of Things

The Internet of Things (IoT) aims to bridge thegap between the physical and the cyber world to allow adeeper understanding of user preferences and behaviors. Theinteractions and relations between users and things need of aneffective and efficient recommendation approaches to bettermeet users interests. Suggesting useful things in IoT environmentis a very important task for many applications such asurban computing, smart cities, health care, etc., and it needs tobe widely investigated. The goal of recommendation systems isto produce a set of significant suggestions for a user with givencharacteristics. In this paper, a multi-agent algorithm that, byexploiting of a decentralized and self organizing strategy, buildsa distributed recommendation system in IoT environment, isproposed. Things are represented through bit vectors, thething descriptors, obtained through a locality preserving hashfunction that maps similar things into similar bit vectors. Cyberagents manage the thing descriptors and exchange them onthe basis of ad-hoc probability functions. The outcome is theemergence of an organized overlay-network of cyber agentsthat allows to obtain an efficient things recommender system. Preliminaries results confirm the validity of the approach.
The CHORCH Approach: How to Model B2Bi Choreographies for Orchestration Execution

The establishment and implementation of cross-organizational business processes is an implication of today’s market pressure for efficiency gains. In this context, BusinessTo-Business integration (B2Bi) focuses on the information integration aspects of business processes. A core task of B2Bi is providing adequate models that capture the message exchanges between integration partners. Following the terminology used in the SOA domain, such models will be called choreographies in the context of this work. Despite the enormous economic importance of B2Bi, existing choreography languages fall short of fulfilling all relevant requirements of B2Bi scenarios. Dedicated B2Bi choreography standards allow for inconsistent outcomes of basic interactions and do not provide unambiguous semantics for advanced interaction models. In contrast to this, more formal or technical choreography languages may provide unambiguous modeling semantics, but do not offer B2Bi domain concepts or an adequate level of abstraction. Defining valid and complete B2Bi choreography models becomes a challenging task in the face of these shortcomings. At the same time, invalid or underspecified choreography definitions are particularly costly considering the organizational setting of B2Bi scenarios. Models are not only needed to bridge the typical gap between business and IT, but also as negotiation means among the business users of the integration partners on the one hand and among the IT experts of the integration partners on the other. Misunderstandings between any two negotiation partners potentially affect the agreements between all other negotiation partners. The CHORCH approach offers tailored support for B2Bi by combining the strengths of both dedicated B2Bi standards and formal rigor. As choreography specification format, the ebXML Business Process Specification Schema (ebBP) standard is used. ebBP provides dedicated B2Bi domain concepts such as so-called BusinessTransactions (BTs) that abstractly specify the exchange of a request business document and an optional response business document. In addition, ebBP provides a format for specifying the sequence of BT executions for capturing complex interaction scenarios. CHORCH improves the offering of ebBP in several ways. Firstly, the execution model of BTs which allows for inconsistent outcomes among the integration partners is redefined such that only consistent outcomes are possible. Secondly, two binary choreography styles are defined as B2Bi implementation contract format in order to streamline implementation projects. Both choreography styles are formalized and provided with a formal execution semantics for ensuring unambiguity. In addition, validity criteria are defined that ensure implementability using BPEL-based orchestrations. Thirdly, the analysis of the synchronization dependencies of complex B2Bi scenarios is supported by means of a multi-party choreography style combined with an analysis framework. This choreography style also is formalized and standard state
Factor Structure of the Brief COPE in People With Mild Traumatic Brain Injury

Objective:To investigate the factor structure and internal consistency of the Brief COPE, adapted for use with adults with mild traumatic brain injury (MTBI). Design:Prospective cohort study. Setting:Hospital based emergency department and concussion clinic. Participants:A total of 147 adults meeting diagnostic criteria for MTBI. Main Measure:Brief COPE. Analyses:The previously reported 9-factor structure of the Brief COPE was tested by using confirmatory factor analysis (CFA) and then exploratory factor analysis (EFA). The Cronbach &agr; was computed for both the original subscales and those derived from EFA. Results:The CFA provided a less than satisfactory fit for the 9-factor model. While the EFA solution was very similar to that of the original scale, the reliability of some derived subscales was low. Further analyses identified improved internal consistency with a 3-factor model reflecting approach, avoidance, and help-seeking coping styles. Conclusions:The Brief COPE has satisfactory psychometric properties for use in MTBI but may be more reliably and meaningfully interpreted using 3 dimensions/subscales rather than 9.
Ectopic Expression of Self-Antigen Drives Regulatory T Cell Development and Not Deletion of Autoimmune T Cells

Type 1 diabetes is a T cell–mediated autoimmune disease that is characterized by Ag-specific targeting and destruction of insulin-producing β cells. Although multiple studies have characterized the pathogenic potential of β cell–specific T cells, we have limited mechanistic insight into self-reactive autoimmune T cell development and their escape from negative selection in the thymus. In this study, we demonstrate that ectopic expression of insulin epitope B:9–23 (InsB9–23) by thymic APCs is insufficient to induce deletion of high- or low-affinity InsB9–23–reactive CD4+ T cells; however, we observe an increase in the proportion and number of thymic and peripheral Foxp3+ regulatory T cells. In contrast, the MHC stable insulin mimetope (InsB9–23 R22E) efficiently deletes insulin-specific T cells and prevents escape of high-affinity thymocytes. Collectively, these results suggest that Ag dose and peptide–MHC complex stability can lead to multiple fates of insulin-reactive CD4+ T cell development and autoimmune disease outcome.
Different Erythromycin Resistance Mechanisms in Group C and Group G Streptococci

ABSTRACT Different mechanisms of erythromycin resistance predominate in group C and G streptococcus (GCS and GGS, respectively) isolates collected from 1992 to 1995 in Finland. Of the 21 erythromycin-resistant GCS and 32 erythromycin-resistant GGS isolates, 95% had the mefA or mefE drug efflux gene and 94% had the ermTR methylase gene, respectively.
MyD88-Dependent Activation of B220−CD11b+LY-6C+ Dendritic Cells during Brucella melitensis Infection1

IFN-γ is a key cytokine controlling Brucella infection. One of its major function is the stimulation of Brucella-killing effector mechanisms, such as inducible NO synthase (iNOS)/NOS2 activity, in phagocytic cells. In this study, an attempt to identify the main cellular components of the immune response induced by Brucella melitensis in vivo is made. IFN-γ and iNOS protein were analyzed intracellularly using flow cytometry in chronically infected mice. Although TCRβ+CD4+ cells were the predominant source of IFN-γ in the spleen, we also identified CD11b+LY-6C+LY-6G−MHC-II+ cells as the main iNOS-producing cells in the spleen and the peritoneal cavity. These cells appear similar to inflammatory dendritic cells recently described in the mouse model of Listeria monocytogenes infection and human psoriasis: the TNF/iNOS-producing dendritic cells. Using genetically deficient mice, we demonstrated that the induction of iNOS and IFN-γ-producing cells due to Brucella infection required TLR4 and TLR9 stimulation coupled to Myd88-dependent signaling pathways. The unique role of MyD88 was confirmed by the lack of impact of Toll-IL-1R domain-containing adaptor inducing IFN-β deficiency. The reduction of IFN-γ+ and iNOS+ cell frequency observed in MyD88-, TLR4-, and TLR9-deficient mice correlated with a proportional lack of Brucella growth control. Taken together, our results provide new insight into how immune responses fight Brucella infection.
Multicolor counterstaining for immunohistochemistry – a modified Movat's pentachrome

Abstract The application of “histochemical” staining procedures has been substantially replaced by immunostaining of specific molecular tissue components. The limited range of colors resulting from routine immunohistochemistry, however, can limit assessment of the general microscopic tissue organization. Consequently we have adapted a polychromatic histochemical counterstaining procedure based on Movat's pentachrome staining sequence for use with immunohistochemical procedures. The value of Movat's original method when applied as an immunohistochemical counterstain is limited by its use of iron hematoxylin and by fact that the resulting color combination is difficult to distinguish from the colors of routine immunohistochemical staining. Our variant pentachrome stains the same tissue components as Movat's stain; however, owing to a modification of the acid fuchsin staining step, it provides a strong color contrast with the reaction product resulting from immunostaining using diaminobenzidine as the chromogen. Multicolor counterstaining for immunohistochemistry offers a new approach to tissue analysis, especially when stromal-epithelial relations of normal and neoplastic tissues are considered.
Fast evaluation of some probability integrals arisen from the valuations of discretely monitored derivative securities

In this paper, we propose a fast numerical method to evaluate discretely monitored derivatives. The key is to compute the involved probability integrals interactively. Our method can avoid the "curse of dimensionality" that most other methods suffer. Also, we give a constructive proof for explicit error estimation that based on a simple and systematic quadrature technique. The numerical frameworks are included for applications of barrier options on a stock and a short rate.
Transient increase in anti-p-ATF2 immunoreactivity in the late secretion ameloblasts apical to the transition zone of rat incisors

Activating transcription factor 2 (ATF2) was localized in the ameloblasts of rat incisors by immunohistochemistry. A specific antibody against phosphorylated ATF2 (p-ATF2), which is an activated form of ATF2, was detected from the proliferation zone to maturation ameloblasts just after the transition. In the secretion zone, a transient increase in p-ATF2 was observed in the late secretion ameloblast nuclei, where a stronger reactivity of p-ATF2 extended from 1 mm apical to the transition to the transition zone, whereas ameloblast nuclei in most of the maturation zone exhibited either weak or no reactivity. A similar pattern was also observed in the case of c-Jun immunohistochemistry, except for in most of the maturation zone, where strong c-Jun reactivity was detected. Thus, ATF-2 and c-Jun are deeply involved in amelogenesis and, in particular, ATF2 is related to the proliferation, differentiation, secretion and transition zones.
Title 1 IntelliEppi : Intelligent reaction monitoring and holistic data management 2 system for the molecular biology lab 3 4 Authors 5

19 Daily alterations of routines and protocols create high, yet so far unmet demands for 20 intelligent reaction monitoring, quality control and data management in molecular biology 21 laboratories. To meet such needs, the “internet of things” is implemented here. We propose 22 an approach which combines direct tracking of lab tubes, reactions and racks with a 23 comprehensive data management system. Reagent tubes in this system are tagged with 2D 24 data matrices or imprinted RFID-chips using a unique identification number. For each tube, 25 individual content and all relevant information based on conducted experimental procedures 26 are stored in an experimental data management system. This information is managed 27 automatically but allow scientists to engage and interfere via user-friendly graphical 28 interface. Tagged tubes are used in connection with a detectable RFID-tagged rack. We show 29 that reaction protocols, HTS storage and complex reactions are easily planned and 30 controlled. 31 32 Introduction 33 The Internet of things is increasingly becoming a tangible reality of the 21st century with 34 examples from the modern factories for automatic assembly lines that work 35 complementarily to a supportive smart-tag based storage system (1). It is not restricted to 36 certain technological areas, instead, with the addition of some creativity, it can be applied to 37 almost every complex process in which electronic devices are involved (2). It is therefore 38 rather surprising that such a development is still missing in most of the modern biological 39 laboratories, where automation is becoming more and more visible through the innovation, 40 improvement of kits, state-of-the-art omics technology and laboratory information 41 management systems (LIMS). 42 First attempts to create integrated LIMS can be traced back to the early 80’s in the form of 43 early patents, whereas, real marketing efforts only became noticeable in recent years, when 44 some leading laboratory equipment suppliers started to develop technology-based 45 intelligent laboratory systems. A good example for this development is the advent of fully 46 automatic systems like Eppendorf’s robotic workstation “epMotion” (3) or Dornier-LTF 47 GmbH’s pipetting robot “PIRO” (4). An automated process for analysis has been proposed in 48 several patents. For instance, Lang and colleagues (5), included “storage” of experimental lab 49 data in the memory of a contactless chip card or a barcode attached to the corresponding 50 reaction vessel. Moreover, RFID (Radio-Frequency Identification) technology has already 51 . CC-BY-NC-ND 4.0 International license not peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was . http://dx.doi. org/10.1101/184721 doi: bioRxiv preprint first posted online Sep. 5, 2017;