Miracle-dz/UniFAR-FTUs huggingface dataset:
Resistance to interpersonal violence : implications for the practice of therapy

ion, as in the practice of decontextualing behaviour, the details and organization of actual (everyday) behaviour take a back seat to the ideologies or theories that are invoked to «(plain it. These ideologies are pretenses, according to Lefebvre, technically subtle 193 and entfdng, but ultimately distracting. They invite us to turn our backs on the most humbie ^ c ts and familiar things, in which 'The unknown . . . is a t its richest" (p. 132). To the «(tent that we are mesmerized by such pretenses, Lefebvre argued: We are unabie to seize the human ^c ts. We Aiil to see them where they are, namely in humble, ^miliar, everyday objects; the shape of fields, of ploughs. Our search for the human takes us too fer, too "deep", we seek it in the clouds or in mysteries, whereas it is waiting for us, besieging us on all sides, (p. 132) The antidote to abstraction, Lefebvre proposed, is that we attend as directly and humbly as possible to what is "besieging us on all sides", that we attem pt to perceive that "which is there in everyday objects, not an abstract lining but something enfolded within which hitherto we have been unable to see" (p. 134; emphasis omitted). Lefebvre referred to his orientation to research as the "archeological mode of reading the everyday" (Trebitsch, 1991, p. xxiv, emphasis added). His method was to observe the actual details of particular activities to elucidate their intelligibility (i.eu, how they make sense from the actoris point of view) in the situations in which they (xxur. In his critique of intellectual abstraction and elitbm, his rehabilitation and elevation of everyday life, and his advocacy of what we would now call an observational and inductive approach to research, Lefebvre has much in common with more recent micro-sodoiogical research, including Goffman's (e.g., 1961), as well as conversation analysis. His influence is also evident in the more recent and highly influential work of Michel Foucault.ion and elitbm, his rehabilitation and elevation of everyday life, and his advocacy of what we would now call an observational and inductive approach to research, Lefebvre has much in common with more recent micro-sodoiogical research, including Goffman's (e.g., 1961), as well as conversation analysis. His influence is also evident in the more recent and highly influential work of Michel Foucault.
A new technique for studying potential changes in nephrons of chick embryo kidneys in vivo.

To make the chick embryo accessible to electrophysiological measurements in its mesonephric kidney during the period between embryonic days (e.d.) 5 and 10, a special "chick-embryo-incubation bath" was constructed. It consists of an aerated chamber covering the egg and maintaining the gas exchange across the shell, and of a warmed reservoir of the incubation medium, into which the embryo is pulled out of the egg through a window in the shell. The two compartments are separated with a rubber membrane tightly fitting to the edges of the shell-window. The incubation medium contains a modified Krebs-Henseleit-Ringer solution and anesthetic Tricaine (Sigma). Access to the mesonephric nephrons is achieved by surgical excision of the body wall on the right side performed at e.d. 5. On average only about 35 percent of the operated embryos survive till the third day after surgery but during the next two days a mortality rate recedes to zero. The tolerance of short-term survival of embryos placed in the incubation bath was tested for up to 4 1/2 h. It was very good in embryos of age 5 to 7 e.d. as assessed by a steady heart rate and the presence of arterio-venous differences. A modified differential amplifier containing circuits for frequency compensation of the two channels was used for high-fidelity registration of voltage changes in the embryonic nephron with a single double-barrel microelectrode.
Energy optimization in ad-hoc networks with MQAM, MFSK, MPSK and MPAM modulations

Determining the most energy-effective modulation technique is essential to elongate the lifetime of energy-constrained ad-hoc networks. In this paper, we consider four different M-ary modulation techniques to optimize the energy consumption cost per successfully received information bit. These digital modulation techniques include linear coherent modulation systems such as MQAM (M-ary Quadrature Amplitude Modulation), MPSK (M-ary Phase Shift Keying), MPAM (M-ary Pulse Amplitude Modulation), and non-linear non-coherent modulation system such as MFSK (M-ary Frequency Shift Keying). For this, we employ interior-point optimization method to solve the proposed problem. The formulation is verified by simulation experiments for various uncoded modulation schemes involving AWGN channel. The results obtained from simulation analyses indicate that the proposed optimization scheme converges to energy-efficient solutions within finite number of iterations.
Understanding the current learning techniques of wayfinding: A case study at Malaysian association for the Blind (MAB)

In preparing blind people to navigate in the real world, they need to be equipped with the knowledge and skills in mobility and orientation. This study aimed to investigate the current learning techniques of way finding for blind people in Malaysia. The study took place at Malaysian Association for the Blind (MAB) where observation and interview were carried out where the objective is first, to explore the existing learning techniques of way finding conducted at MAB and second, to identify the problems faced by the mobility and orientation (M&O) instructor in teaching way finding. The study revealed that the main problem faced by the instructor was lack of appropriate tools used to describe the environment to blind students. This led to the difficulties in developing the cognitive maps of the described environment for some blind students at MAB. However, positive responses given by the blind students after using an audio-tactile map which helped them to alleviate the problems they were facing.
A new energy management strategy for a grid connected wind turbine-battery storage power plant

This paper presents an innovative energy management strategy for the power dispatch of an island grid-connected hybrid plant combining a battery energy storage system (BESS) and a wind energy conversion system (WECS). The power plant must inject power into the grid in a continuous manner according to a penalty system related to a commitment band for the injection. Aiming at the revenues maximization, an energy management system (EMS) is proposed to efficiently handle the charge/discharge cycles of the battery system as well as its state-of-charge (SoC) so that the generation engagements can be met while considering the battery lifespan. The strategy, based on model predictive control (MPC) and quadratic programming (QP), is tested through simulation with real wind farm data using Matlab Simulink.
Expression of NOX1, a superoxide‐generating NADPH oxidase, in colon cancer and inflammatory bowel disease

Reactive oxygen species (ROS) are at the centre of many physiological and pathological processes. NOX1, a ROS‐producing NADPH oxidase, is highly expressed in the colon but its function in colonic physiology or pathology is still poorly understood. It has been suggested to play a role in host defence, but also in cell growth and possibly malignant transformation. In this study we characterized NOX1 expression in human colon samples derived from healthy control subjects and patients with colon cancer or inflammatory bowel disease (IBD). NOX1 mRNA expression was assessed by dot‐blot hybridization, real‐time PCR and in situ hybridization, using samples derived from surgical specimens from patients undergoing colon resection. In normal tissues, NOX1 expression was low in the ileum, intermediate in the right colon, and high in the left colon (p = 0.0056 right vs. left colon). NOX1 mRNA levels were not influenced by factors linked to colon tumourigenesis, such as age or sex. Moreover, there was no statistical difference in NOX1 expression between samples derived from adenomas, well differentiated or poorly differentiated colon adenocarcinomas. At a cellular level, NOX1 was highly expressed in colon epithelial cells, both within the crypts and on the luminal surface. In addition, a population of lymphocytes, particularly in the appendix, showed NOX1 expression. Lymphocytes in lesions of Crohn's disease and ulcerative colitis were also strongly positive for NOX1. In conclusion, NOX1 is an enzyme that is constitutively expressed in colon epithelium and is not associated with tumourigenesis. Its distribution in crypts and on the luminal surface, as well as its left‐to‐right gradient in the colon, suggests a role in host defence function. In addition to the known epithelial localization, we define lymphocytes as a novel site of NOX1 expression, where it may potentially be involved in the pathogenesis of inflammatory bowel diseases. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The shielding effect of HTS power cable based on E-J power law

A method for analysing the current distribution in high-T/sub c/ superconducting (HTS) power cable is examined by the aid of the novel use of anisotropic conductivity and 3-D finite element method considering E-J power law characteristic. The detailed current distribution in the cable is illustrated and the shielding effect of HTS shield layer with intervals is also examined. It is shown that AC losses in shield layer with intervals are increased when the interval between wires becomes large.
Fusion of the FUS gene with ERG in acute myeloid leukemia with t(16;21)(p11;q22)

It has been shown that the gene ERG in 21q22 is rearranged in the the t(16;21)(p11;q22) associated with acute myeloid leukemia (AML). ERG is a member of the ETS gene family and is fused with EWS in a subset of Ewing's sarcomas. EWS in 22q12 has a very high homology with FUS (also called TLS) in 16p11; the latter gene is rearranged in the t(12;16)(q13;p11) that characterizes myxoid liposarcoma. To investigate whether FUS is involved in the t(16;21) of AML, we used the Southern blot technique and polymerase chain reaction (PCR) to examine the bone marrow of a 3‐year‐old boy with a t(16;21)(p11;q22)‐positive AML. Hybridization of Southern blot filters containing digested DNA with probes for FUS and ERG showed both germline and aberrant fragments. Using specific primers for the 5′ part of FUS and the 3′ part of ERG, we amplified a 4.4 kb genomic FUS/ERG DNA fragment from the leukemic sample. In a second PCR experiment, in which we used primers upstream of the 5′ part of ERG and downstream of the 3′ part of FUS, a 5.6 kb fragment was amplified. Blotting and hybridization with specific probes for FUS and ERG revealed that the amplified fragments consisted of FUS/ERG and ERG/FUS hybrid DNA. Both PCR fragments, when used as probes, detected germline ERG and FUS as well as aberrant fragments on Southern blot filters. The results suggest that the t(16;21) in AML leads to rearrangement and fusion of the FUS and ERG genes. This is the first example in which two genes, each known to recombine with other genes in different solid tumor types (FUS in myxoid liposarcoma and ERG in Ewing's sarcoma), are fused in a hematologic malignancy.
Lipid Rafts in Cryptococcus neoformans Concentrate the Virulence Determinants Phospholipase B1 and Cu/Zn Superoxide Dismutase

ABSTRACT Lipid rafts have been identified in the membranes of mammalian cells, the yeast Saccharomyces cerevisiae, and the pathogenic fungus Candida albicans. Formed by a lateral association of sphingolipids and sterols, rafts concentrate proteins carrying a glycosylphosphatidylinositol (GPI) anchor. We report the isolation of membranes with the characteristics of rafts from the fungal pathogen Cryptococcus neoformans. These characteristics include insolubility in Triton X-100 (TX100) at 4°C, more-buoyant density within a sucrose gradient than the remaining membranes, and threefold enrichment with sterols. The virulence determinant phospholipase B1 (PLB1), a GPI-anchored protein, was highly concentrated in raft membranes and could be displaced from them by treatment with the sterol-sequestering agent methyl-β-cyclodextrin (MβCD). Phospholipase B enzyme activity was inhibited in the raft environment and increased 15-fold following disruption of rafts with TX100 at 37°C. Treatment of viable cryptococcal cells in suspension with MβCD also released PLB1 protein and enzyme activity, consistent with localization of PLB1 in plasma membrane rafts prior to secretion. The antioxidant virulence factor Cu/Zn superoxide dismutase (SOD1) was concentrated six- to ninefold in raft membrane fractions compared with nonraft membranes, whereas the cell wall-associated virulence factor laccase was not detected in membranes. We hypothesize that raft membranes function to cluster certain virulence factors at the cell surface to allow efficient access to enzyme substrate and/or to provide rapid release to the external environment.
Epidemiological dynamics of an urban Dengue 4 outbreak in São Paulo, Brazil

Background: Dengue studies at the urban scale are scarce and required for guiding control efforts. In Brazil, the burden of dengue is high and challenges city public health administrations with limited resources. Here we studied the dynamics of a dengue epidemic in a single city. Methods: Serum samples from dengue suspected cases were collected and tested, from December 2012 and July 2013 in Guarujá, Brazil. We use incidence series analysis to provide a detailed view of the reproduction number dynamics and a Bayesian analysis to infer the spread of the serotype using geographic and temporal data. Results: We obtained nucleotide sequences from 354 envelope genes and georeferenced 286 samples during the course of the outbreak. Serotype 4 was responsible for the epidemic. We identified at least two major lineages that overlapped in distribution. We observed high reproduction numbers and high cladogenesis prior to the escalation of clinical case notifications. Three densely populated non-adjacent neighborhoods played a pivotal role during the onset and/or course of the epidemic. Discussion: Our findings point to high dengue virus transmission with a substantial proportion of unapparent cases that led to a late recognition of an outbreak. Usually source reductions initiatives tend to be insufficient once an epidemic has been established. Nevertheless, health authorities in Guarujá prioritized vector control on specific places with clusters of georeferenced viremic patients, which appear to have diminished the epidemic impact.
Increased Power for the Analysis of Label-free LC-MS/MS Proteomics Data by Combining Spectral Counts and Peptide Peak Attributes*

Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics provides a wealth of information about proteins present in biological samples. In bottom-up LC-MS/MS-based proteomics, proteins are enzymatically digested into peptides prior to query by LC-MS/MS. Thus, the information directly available from the LC-MS/MS data is at the peptide level. If a protein-level analysis is desired, the peptide-level information must be rolled up into protein-level information. We propose a principal component analysis-based statistical method, ProPCA, for efficiently estimating relative protein abundance from bottom-up label-free LC-MS/MS data that incorporates both spectral count information and LC-MS peptide ion peak attributes, such as peak area, volume, or height. ProPCA may be used effectively with a variety of quantification platforms and is easily implemented. We show that ProPCA outperformed existing quantitative methods for peptide-protein roll-up, including spectral counting methods and other methods for combining LC-MS peptide peak attributes. The performance of ProPCA was validated using a data set derived from the LC-MS/MS analysis of a mixture of protein standards (the UPS2 proteomic dynamic range standard introduced by The Association of Biomolecular Resource Facilities Proteomics Standards Research Group in 2006). Finally, we applied ProPCA to a comparative LC-MS/MS analysis of digested total cell lysates prepared for LC-MS/MS analysis by alternative lysis methods and show that ProPCA identified more differentially abundant proteins than competing methods.
Neighbourhood Built Environment Influences on Physical Activity among Adults: A Systematized Review of Qualitative Evidence

Qualitative studies can provide important information about how and why the built environment impacts physical activity decision-making—information that is important for informing local urban policies. We undertook a systematized literature review to synthesize findings from qualitative studies exploring how the built environment influences physical activity in adults. Our review included 36 peer-reviewed qualitative studies published from 1998 onwards. Our findings complemented existing quantitative evidence and provided additional insight into how functional, aesthetic, destination, and safety built characteristics influence physical activity decision-making. Sociodemographic characteristics (age, sex, ethnicity, and socioeconomic status) also impacted the BE’s influence on physical activity. Our review findings reinforce the need for synergy between transportation planning, urban design, landscape architecture, road engineering, parks and recreation, bylaw enforcement, and public health to be involved in creating neighbourhood environments that support physical activity. Our findings support a need for local neighbourhood citizens and associations with representation from individuals and groups with different sociodemographic backgrounds to have input into neighbourhood environment planning process.
First trimester diagnosis of monoamniotic twin pregnancies

This study reports the ultrasound findings and pregnancy outcome for a series of monoamniotic twin pregnancies diagnosed at 11–14 weeks' gestation. Of 315 monochorionic twin pregnancies examined, there were 12 (3.8%) monoamniotic, including four sets of conjoined twins (1.3%). The parents opted for termination of pregnancy in all cases of conjoined twins. In four other cases, there was discordancy for major structural fetal abnormality (kyphoscoliosis, anencephaly, body stalk defect, diaphragmatic hernia), and the co‒twin was structurally normal. In the four cases in which both twins were structurally normal, ultrasound examination demonstrated normal nuchal translucency thickness in all cases but cord entanglement was demonstrated from the first trimester. Two cases were managed expectantly; one resulted in livebirth of both twins at 31 weeks' gestation and the second in intrauterine death of both fetuses at 21 weeks. Two pregnancies were treated with Sulindac; one resulted in a single intrauterine death at 30 weeks and delivery of a normal co‒twin, the other, in intrauterine death of both fetuses at 31 weeks'. Monoamniotic twin pregnancies are associated with a high risk of fetal abnormalities and perinatal death and the mortality rate is higher than previously reported from series with recruitment later in gestation. Copyright © 2000 International Society of Ultrasound in Obstetrics and Gynecology
Psychoacoustic analyses of cochlear mechanisms in tinnitus patients with normal auditory thresholds

Abstract Objective: Tinnitus is often related to auditory dysfunction. We hypothesised that, among individuals with normal auditory thresholds, the mechanism of frequency selectivity might differ between subjects with and without tinnitus. Our objective was to identify any differences between normal-hearing individuals with tinnitus and those without in terms of psychophysical tuning curves (PTCs) and threshold-equalising noise (TEN) test results. Design: We determined PTCs and performed the TEN test. Study sample: We evaluated 57 individuals, 16 with bilateral tinnitus (tinnitus-group) and 41 without tinnitus (control-group). Results: We found significant differences between tinnitus and control groups regarding the following: 2 kHz PTCs obtained in noise at 6 and 8 kHz; 4 kHz PTCs obtained in noise at 2 and 8 kHz; and 6 and 8 kHz PTCs obtained in noise at 2 and 3 kHz. The TEN test revealed differences between groups in terms of auditory thresholds, which were significantly higher in the tinnitus group. In addition, none of the individuals in the tinnitus group were found to have dead regions in the cochlea. Conclusions: Despite having normal auditory thresholds, individuals with tinnitus have auditory patterns that differ significantly from those seen in individuals without tinnitus, such differences being suggestive of cochlear impairment.
A Computational Examination of Image Segmentation and the Initial Stages of Human Vision

A novel approach to the question of image segmentation is considered. Instead of relying on edge-detection mechanisms to encircle the image of an object, it is proposed that the general Gestalt-like properties of images of objects can be used. These manifest themselves as particularly simple properties at relatively coarse spatial scales when the image is filtered with orientation-selective filters. The first part of the paper is concerned with a computational analysis of this proposal. A key issue is the question of how the information in filtered images is extracted. A simple primitive parametric description of zero-bounded blobs is used in this paper. It is shown how such a scheme can support readily the clustering of features with Gestalt-like properties. In the second part of the paper, two general difficulties for vision that are particularly severe for the present scheme are considered. The first of these are the effects of strongly asymmetric illumination. The second are the effects of using a cluttered scene. In each case the nature of the problem is examined and the nature of the computational solution considered.
Mediation Analyses of Insight, Quality of Life, Depression, and Suicidality: Results From the FACE-SZ Cohort.

OBJECTIVE The relationship between greater insight and increased risk of suicide in patients with schizophrenia is debated. The purpose of this study was to assess whether quality of life (QoL) and depression mediated the association between insight and suicidality. METHODS Between March 2010 and December 2015, 527 community-dwelling adults with stable schizophrenia according to DSM-IV criteria were included in a multicenter cross-sectional study, the FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) Study. Structural equation modeling was used for mediation analyses among insight, QoL, depression, and suicidality, controlling for the global level of schizophrenic symptoms. RESULTS The model provided a good fit for the data (χ²₃ = 1.4, P = .708, Tucker-Lewis index = 1, comparative fit index = 1, root mean square error of approximation = 0, standardized root mean square residual = 0.008) and explained 27% of the variance in suicidality. Poorer QoL and greater severity of depression mediated 68.4% of the positive association between insight and suicidality (full mediation). Poorer QoL mediated 48% of the positive effect of insight on depression (partial mediation). The severity of depression mediated 91.2% of the negative relationship between QoL and suicidality (full mediation). CONCLUSIONS Insight appears to be an indirect risk factor for suicide in patients with schizophrenia, with the link being mediated by poorer QoL and worse underlying depression, mainly by a sequential pathway but also by a less important parallel pathway.
Word Segmentation in Japanese for Construction of Scientific Japanese Corpus

Japanese word segmentation in the specialized field is the difficulty of building the Scientific Japanese Corpus. This paper deeply studied the basic problem of the word segmentation. They are ambiguity and words without login. In this paper we tried to use the ART network and immune principle to solve the problem of Japanese word segmentation, more than 90% of the words are correctly separated by our method.