Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of tension band wires in horses with fractures of the ulna: 22 cases (1980-1992).

Twenty-two horses with ulnar fractures were treated, using tension band wires alone or tension band wires in combination with pins or cortical bone screws. Age of the horses ranged from 2 weeks to 12 years (median, 4 months), and body weight ranged from 68 to 477 kg (median, 181 kg). Fractures were classified according to the Donecker and Bramlage ulnar fracture classification and included type 1-a (4 horses), type 1-b (4), type-2 (6), type-3 (1), type-4 (3), and type-5 (4), fractures. Tension band wires alone were used in 7 horses. Tension band wires were used in conjunction with unthreaded pins in 10 horses. In 3 horses, 5.5-mm cortical bone screws were inserted longitudinally instead of pins. A combination of a 5.5-mm cortical bone screw and a pin was used in 2 horses. In addition to pins and tension band wires, 4.5-mm cortical bone screws were placed in lag fashion to aid reduction of comminuted or oblique fractures in 7 of the 22 horses. Fractures healed in 18 (82%) horses. Four horses were euthanatized because of complications that included catastrophic failure of fixation during recovery from general anesthesia in 1 foal, septic arthritis and hyperextension of the contralateral metacarpophalangeal joint in 1 foal, and wound infection with partial disruption of repair in 2 horses. Nonfatal complications developed in 6 horses and included incision infection, partial wound dehiscence, carpal contraction, carpus varus of the contralateral forelimb, slight distraction of proximal fragments of the fractures, bent implants, and distal migration of pins. Long-term monitoring was performed on 17 horses. (ABSTRACT TRUNCATED AT 250 WORDS)
Religion and culture

REL-1002 (3) Exploring Religions: World's Religions (3 hrs Lecture) Religion is a universal phenomenon that varies in meaning from culture to culture. This course examines the ways religion is understood in different cultures, introducing basic concepts used in the academic study of religion (e.g., sacred and profane, myth and history, symbol and ritual, etc.) through a survey of the major world religious traditions (e.g., Judaism, Christianity, Islam, Hinduism, Buddhism, Confucianism, Taoism, and the religions of indigenous peoples of North and South America). The teachings of individual traditions, how these teachings developed over time, and differences in interpretation will be examined against the background of the culture that produced them.
Residual-Based Tests for Fractional Cointegration: Testing the Term Structure of Interest Rates

Campbell and Shiller (1987) and Hall et al. (1992) suggest that the term spread of long-term and short-term interest rates should be a stationary I(0) process. However, an empirically nonstationary term spread or rejection of cointegration between long and short term interest rates need not to be considered an empirical rejection of this theoretical relationship. It is likely that the dichotomy between I(1) or I(0) and/or integer values of cointegration are environments which are too restrictive to model the term structure. To overcome this problem, we propose a residual-based approach to test for the null of no cointegration against a fractional alternative which relies on the Exact Local Whittle Estimator (Shimotsu and Philllips, 2005, 2006). We compare its performance to other residual-based tests for fractional cointegration, and then we use it to investigate the term structure in the U.K and the U.S.
The Impact of a Sport Mega-Event on Destination Image

Abstract There is intense competition to host sports mega-events as cities and countries perceive that doing so will enhance their global image and make the destination more attractive to future tourists. Is there empirical evidence to prove that hosting a mega sport event really does stimulate international visitation and enhance the destination's image? In this paper we investigate this question in relation to the 2002 FIFA World Cup, co-hosted by South Korea and Japan. To this end, 412 foreign tourists were surveyed during the World Cup about their image of South Korea. Differences in demographics, motive and perceptions between tourists travelling specifically for the World Cup, and those coming to South Korea for non-World Cup-related reasons, are noted. The study provides a baseline dataset from which future research on megasports events can build.
Csk Is Constitutively Associated with a 60-kDa Tyrosine-phosphorylated Protein in Human T Cells (*)

The protein-tyrosine kinase Csk is one of the main down-regulators of the Src family of kinases. Csk may be involved in the down-regulation of T cell receptor (TCR) signaling by C-terminal tyrosine phosphorylation of Lck and Fyn; however, it is not known how Csk activity is regulated or how it targets these Src family members. We used Jurkat T cells and normal human T cells to examine proteins that bind to the SH2 domain of Csk. In both Jurkat and normal T cells, the Src homology 2 (SH2) domain of Csk bound constitutively to a tyrosine-phosphorylated protein of 60 kDa (p60). The 60-kDa protein was detected in Csk immunoprecipitates from both unstimulated and CD3-stimulated cells. In addition to p60, a protein of 190 kDa coprecipitated with Csk, and both proteins were phosphorylated on tyrosine residues by the immunocomplex. Small amounts of GTPase-activating protein (GAP) were detected in anti-Csk immunoprecipitates, suggesting that p60 may be a GAP-associated protein. Our data demonstrate that the SH2 domain of Csk specifically associates with at least two tyrosine-phosphorylated proteins in normal human T cells, that this association is independent of TCR/CD3 activation, and that Csk may be a part of a multiprotein complex containing GAP.
Sites of ubiquitin attachment in Saccharomyces cerevisiae

Sites of ubiquitin modification have been identified by mass spectrometry based on the increase in molecular mass of a tryptic peptide carrying two additional glycine residues from the ubiquitin moiety. However, such peptides with GG shifts have been difficult to discover. We identify 870 unique sites of ubiquitin attachment on 438 different proteins of the yeast Saccharomyces cerevisiae.
Debt And Lending: A Cri De Coeur

Many papers published by the Levy Institute during the last few years have emphasized that the U.S. economy has relied too much on the growth of lending to the private sector, most particularly to the personal sector, to offset the negative effect on aggregate demand of the growing current account deficit. Moreover, this growth in lending cannot continue indefinitely.
Modelling photonic bandgap structures having multiple defects

The modelling of defects in photonic crystals (PC) by traditional numerical methods is difficult because it requires much memory and computing time. An analytical method of multiple-scattering solves this typical problem for spherical inclusions. Only this method does the study of lattices made up with a great number of spheres. This method finds the minimal number of spheres to obtain equivalence between finite and infinite photonic crystals. From ordered to disordered systems, we have used this method to study the effects of random variations of the radii and positions of the spheres in the lattice.
Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents

Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14‐year‐old adolescents (n = 4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (Padj = 0.0067; odds ratio = 1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.
Na/H exchange and H-K ATPase increase distal tubule acidification in chronic alkalosis.

We examined whether H(+)-ATPase, H(+)-K(+)-ATPase, and or Na+/H+ exchange mediates increased distal tubule acidification in animals with chronic metabolic alkalosis using pharmacological inhibitors of these H+ transporters in in vivo-perfused tubules of anesthetized rats. Chronic metabolic alkalosis was induced with furosemide followed by minimum electrolyte diet and HCO3 drinking water. The reduction in net HCO3 reabsorption was greater in distal tubules of alkalotic compared to control animals perfused with Schering 28080 to inhibit H(+)-K(+)-ATPase (-6.4 +/- 0.9 vs. -1.4 +/- 0.5 pmol/mm.min-1, P < 0.02) and with EIPA to inhibit Na+/H+ exchange (-11.1 +/- 1.7 vs. -6.6 +/- 0.9 pmol/mm.min-1, P < 0.01) but was similar in distal tubules of alkalotic and control animals perfused with bafilomycin to inhibit H(+)-ATPase. The greater reduction of distal tubule net HCO3 reabsorption in alkalotic compared to control animals induced by EIPA was eliminated by systemic infusion of the endothelin receptor antagonist bosentan (-4.6 +/- 0.7 vs. -4.4 +/- 0.7 pmol/mm.min-1, P = NS) but the greater reduction induced by Schering 28080 persisted. Urine endothelin-1 (ET-1) excretion was higher in animals with maintained alkalosis (164.5 +/- 23.7 vs. 76.6 +/- 10.8 fmol/day, P < 0.03), but decreased following KCl repletion to a value (86.7 +/- 10.0 fmol/day, P < 0.02 vs. respective before-KCl value) that was not different from that for KCl-repleted control animals (79.9 +/- 8.7 fmol/day, P = NS vs. KCl-repleted alkalotic animals). The data support that augmented distal tubule acidification in alkalotic animals is due to increased H(+)-K(+)-ATPase and Na+/H+ exchange activity, the latter stimulated by endogenous endothelins.
Evaluating Abdominal and Lower-Back Muscle Activity While Performing Core Exercises on a Stability Ball and a Dynamic Office Chair

Objective: The purpose of this study was to evaluate the ability of a dynamic office chair to activate the core muscles while participants performed exercises sitting on the chair compared to a stability ball. Background: Prolonged sitting has become an accepted part of the modern office. However, epidemiological evidence suggests that sedentary postures are linked to many adverse effects on health. The concept of dynamic or active sitting is intended to promote movement while sitting to reduce the time spent in prolonged, static postures. Methods: Sixteen participants performed four pelvic rotation exercises (front-back, side-side, circular, and leg lift) on both a dynamic office chair and a stability ball. Muscle activity from 12 torso muscles were evaluated with surface electromyography. Results: For all exercises, trunk muscle activity on the chair was comparable to that on a stability ball. The right external oblique was the only muscle to produce greater peak activity (p = .019) when using the ball compared to the chair (21.4 ± 14.0 percent maximal voluntary excitations (%MVE) and 14.7 ± 10.8 %MVE for the ball and chair, respectively). The left thoracic erector spinae produced greater average activity (p = .044) on the chair than on the ball. Conclusion: These findings suggest that this dynamic sitting approach could be an effective tool for core muscle activation while promoting movement and exercise while sitting at work. Application: Muscle activations on the dynamic chair are comparable to those on a stability ball, and dynamic office chairs can promote movement and exercise while sitting at work.
Together or Separate? Post-Conflict Partition, Ethnic Homogenization, and the Provision of Public Schooling

The partitioning of political jurisdictions is becoming an increasingly common component of agreements to end ethnic conflict, although its impact on post-conflict recovery remains unclear. This paper studies the effects of the partition which ended the 1992–1995 Bosnian War on the post-war provision of public schooling. I find that partitioned municipalities provide 58% more primary schools and 37% more teachers (per capita). Driven mainly by convergent preferences for ethnically oriented schools, however, this arrangement delivers distributional consequences: in partitioned municipalities, ethnic majority children are more likely to complete primary schooling, while for ethnic minority children it is the opposite.
Reliability of the Brazilian version of HCR-20 Assessing Risk for Violence.

OBJECTIVE Assessing risk for violence is a complex task often based on not objective or structured clinical evaluations. HCR-20 Assessing Risk for Violence has been used in several countries to increase the accuracy of this exam. The purpose of this study was to inform on central aspects of this instrument, as well as the results of the reliability assessment of the HCR-20 Assessing Risk for Violence in a Brazilian inpatient criminal population. METHOD Two examiners independently assessed a random sample of 30 patients that were under criminal commitment at the Mauricio Cardoso Forensic Psychiatric Institute RESULTS Mean consensus values means were as follows: Historical = 13.1; Clinical = 4.8 and Risk management = 5.8. The value of the Intraclass Correlation Coefficient for the score of subscale Historical was 0.97, for subscale Clinical it was 0.94, and for subscale Risk management, 0.96. As to the individual items of the HCR-20 Assessing Risk for Violence, the result of the Intraclass Correlation Coefficient was good to excellent (mean = 0.97; interval, from 0.60 to 0.99). CONCLUSION The interrater reliability of the Brazilian version of the HCR-20 Assessing Risk for Violence scale was similar to the results of studies in other countries.
Predicting Human Interaction via Relative Attention Model

Predicting human interaction is challenging as the on-going activity has to be inferred based on a partially observed video. Essentially, a good algorithm should effectively model the mutual influence between the two interacting subjects. Also, only a small region in the scene is discriminative for identifying the on-going interaction. In this work, we propose a relative attention model to explicitly address these difficulties. Built on a tri-coupled deep recurrent structure representing both interacting subjects and global interaction status, the proposed network collects spatio-temporal information from each subject, rectified with global interaction information, yielding effective interaction representation. Moreover, the proposed network also unifies an attention module to assign higher importance to the regions which are relevant to the on-going action. Extensive experiments have been conducted on two public datasets, and the results demonstrate that the proposed relative attention network successfully predicts informative regions between interacting subjects, which in turn yields superior human interaction prediction accuracy.
Cloning, mapping and nucleotide sequencing of a gene encoding a universal stress protein in Eschericha coli

The response of non‐differentiating bacteria to nutrient starvation is complex and includes the sequential synthesis of starvation‐inducible proteins. Although starvation for different individual nutrients generally provokes unique and individual patterns of protein expression, some starvation stimulons share member proteins. Two‐dimensional polyacrylamide gel electrophoresis revealed that the synthesis of a small (13.5 kDa) cytoplasmic protein in Escherichia coli was greatly increased during growth inhibition caused by the exhaustion of any of a variety of nutrients (carbon, nitrogen, phosphate, sulphate, required amino acid) or by the presence of a variety of toxic agents including heavy metals, oxidants, acids and antibiotics. To determine further the mode of regulation of the protein designated UspA (üniversal stress pUrotein A) we cloned the gene encoding the protein by the technique of reverse genetics. We isolated the protein from a preparative two‐dimensional polyacrylamide gel, determined its N‐terminal amino acid sequence, and used this sequence to construct a degenerate oligonucleotide probe. Two phages of the Kohara library were found to contain the gene which then was subcloned from the DNA in the overlapping region of these two clones. The amino acid sequence, deduced from the nucleotide sequence of the uspA gene, shows no significant homology with any other known protein. The uspA gene maps at 77 min on the E. coli W3110 chromosome, and is transcribed in a clockwise direction. The increase in the level of UspA during growth arrest was found to be primarily a result of transcriptional activation of the corresponding gene. The induction was independent of the RelA/SpoT, RpoH, KatF, OmpR, AppY, Lrp, PhoB and H‐NS proteins during stress conditions that are known to induce or activate these global regulators. The ‐10 and ‐35 regions upstream of the transcriptional start site of the uspA gene are characteristic of a σ70‐dependent promoter.
Are Credit Scoring Models Able to Predict Small Enterprise Default? Statistical Evidence from Italian Small Enterprises

From as early as the 1960s, there have been a large number of studies aimed at assessing the application of statistical models to corporation data with a view to predicting business failure. This issue has become increasingly important in recent years, as the New Basel Capital Accord (Basel II) linked capital requirements to banks’ models for company default prediction. Empirical research shows that economic-financial ratios can help to predict company default through the implementation of statistical techniques. The literature focuses mainly on large and medium sized enterprises that systematically produce detailed financial documentation. However, the financial statements of small enterprises (SEs) tend to disclose less (and are therefore more difficult to interpret), and this prevents a widespread use of statistical models. The issue is of vital importance in countries like Italy with large numbers of SEs. This paper applies mainstream statistical techniques (linear discriminant analysis and logistic regression) to a sample of over 6,000 Italian firms in the attempt to develop two distress prediction models, specifically constructed for SEs and taking into account diversity of size, geographical location and business sector. For both models, prediction accuracy increases progressively with larger firms, and is higher in the North and in manufacturing firms. The success rate is lower in smaller firms and for those located in Southern Italy. Our results suggest that the limited information in SE accounts affects a model’s prediction success rate, and also that SEs need to be assessed with specifically designed models.
Differences in Treatment Patterns and Health Care Costs among Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia Patients Receiving Rituximab in the Hospital Outpatient Setting versus the Office/Clinic Setting

Objective: To examine whether differences in treatment patterns and health care costs exist among chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL) patients receiving rituximab in a hospital outpatient setting versus those receiving rituximab in a physician office/community clinic setting. Methods: This retrospective database study used medical and pharmacy claims (1/2007-7/2012) from a large US health plan. Patients ≥18 years with ≥2 rituximab claims and ≥2 claims for either NHL or CLL were identified. The date of the first rituximab claim were set as the index date, and differences in treatment patterns and health care costs were examined during the period following the index date. Costs were adjusted for patient characteristics using a multivariate regression model. Results: A total of 4441 patients were identified; 3167 received rituximab in the office/clinic setting, and 1274 in the hospital outpatient setting. From 2007 to 2012, the percentage of patients receiving rituximab in the hospital outpatient setting increased from 22% to 39%. Patients treated in the hospital outpatient setting vs. the office/clinic setting had fewer average counts of rituximab infusions (5.60 vs. 7.49, p 0.001), higher total health care costs (cost ratio = 1.325, p 0.001), higher infusion day drug and administration costs (cost ratio = 1.509, p 0.001), and higher rates of ER visits and inpatient stays (both p 0.001). Conclusions: These findings suggest that site of care may impact treatment patterns and costs of patients receiving rituximab, and additional research is needed to better understand the reason(s) for these differences by site of service.
The appraisal of road construction projects : a practical example

SOME time ago, an attempt was made to develop a practical method for the appraisal of projects of road construction.1 The proposed method is one of comparative statics and compares the national product before and after the construction of a road. The essential elements of the method are the following. The whole economy is divided into a number of geographically separated centers. The movement of products from one center to another gives rise to transportation costs and, consequently, the price of the product of center i in center k depends on the costs of transportation from i to k. Supply and demand equations are assumed for each center and each product. The supply of each product i depends on the price of product i and the prices in i of all other products as cost elements. Two alternative assumptions are made with regard to the reactions of demand to price changes:
Heparin-Regulated Prodrug-Type Macromolecular Theranostic Systems for Cancer Therapy

Heparin is a kind of naturally occurring polymer with excellent biocompatibility and solubility. It is characterized by dense of negative charge, higher than any endogenous components. Heparin can bind with various cationic peptides and proteins, thereby providing a useful noncovalent linkage for building a drug delivery system. As a case in point, heparin/cell-penetrating peptides (CPP) interaction is strong, and remains stable in vivo. They can be used to modify different proteins, respectively, and subsequently, by simply mixing the modified proteins, a protein-protein conjugate can be form via the stable heparin/CPP linkage. This linkage could not be broken unless addition of protamine that bears higher cationic charge density than CPP, and CPP thus can be substituted and released. Of note, heparin is a potent antagonist of CPP, and their binding naturally inhibits CPP-mediated drug cell penetration. Based on this method, we developed a heparin-regulated macromolecular prodrug-type system, termed ATTEMPTS, for drug targeting delivery. In this review article, we mainly summary the application of ATTEMPTS in delivery of various macromolecular drugs for cancer therapy, and also introduce the heparin-regulated nanoprobes for tumor imaging.
Finance and Inequality: Channels and Evidence

We provide a framework to interpret the recent literature on financial development and inequality. In many developing countries, access to funding and financial services by firms and households is still very skewed. Recent evidence suggests that poor access does not only reflect economic constraints but also barriers erected by insiders. Inequality affects the distribution of political influence, so financial regulation often is easily captured by established interests in unequal countries. Captured reforms deepen rather than broaden access, as small elites obtain most of the benefits while risks are socialized. Financial liberalization motivated to increase access may in practice increase fragility and inequality, and lead to political backlash against reforms. Thus financial reforms may succeed only if matched by a buildup in oversight institutions.