Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of intravenously administered recombinant vesicular stomatitis virus (VSV(deltaM51)) on multifocal and invasive gliomas.

BACKGROUND An ideal virus for the treatment of cancer should have effective delivery into multiple sites within the tumor, evade immune responses, produce rapid viral replication, spread within the tumor, and infect multiple tumors. Vesicular stomatitis virus (VSV) has been shown to be an effective oncolytic virus in a variety of tumor models, and mutations in the matrix (M) protein enhance VSV's effectiveness in animal models. METHODS We evaluated the susceptibility of 14 glioma cell lines to infection and killing by mutant strain VSV(deltaM51), which contains a single-amino acid deletion in the M protein. We also examined the activity and safety of this strain against the U87 and U118 experimental models of human malignant glioma in nude mice and analyzed the distribution of the virus in the brains of U87 tumor-bearing mice using fluorescence labeling. Finally, we examined the effect of VSV(deltaM51) on 15 primary human gliomas cultured from surgical specimens. All statistical tests were two-sided. RESULTS All 14 glioma cell lines were susceptible to VSV(deltaM51) infection and killing. Intratumoral administration of VSV(deltaM51) produced marked regression of malignant gliomas in nude mice. When administered systemically, live VSV(deltaM51) virus, as compared with dead virus, statistically significantly prolonged survival of mice with unilateral U87 tumors (median survival: 113 versus 46 days, P = .0001) and bilateral U87 tumors (median survival: 73 versus 46 days, P = .0025). VSV(deltaM51) infected multifocal gliomas, invasive glioma cells that migrated beyond the main glioma, and all 15 primary human gliomas. There was no evidence of toxicity. CONCLUSIONS Systemically delivered VSV(deltaM51) was an effective and safe oncolytic agent against laboratory models of multifocal and invasive malignant gliomas, the most challenging clinical manifestations of this disease.
RANKL Coordinates Cell Cycle Withdrawal and Differentiation in Osteoclasts Through the Cyclin‐Dependent Kinase Inhibitors p27KIP1 and p21CIP1

The coordination of cell cycle progression and osteoclast differentiation by RANKL signaling was studied. Experiments with mouse genetic models revealed that RANKL promoted cell cycle withdrawal of osteoclast precursors dependent on the cyclin kinase inhibitor p27‐KIP1, but that both p27‐KIP1 and p21‐CIP1 were required for osteoclast differentiation. These cyclin inhibitors may directly regulate osteoclast differentiation in addition to regulating cell cycle withdrawal.
Collision-free trajectory planning on Lissajous curves for repeated multi-agent coverage and target detection

This paper proposes a trajectory planning strategy to simultaneously address multiple surveillance objectives such as complete area coverage, periodic surveillance, and guaranteed detection of a rogue element attempting to exit the area of interest. For agents with identical sensing capability, the proposed strategy defines a time-varying multi-agent formation on a Lissajous curve, which completes the aforementioned tasks in finite time with collision free paths for all agents in a 2-D rectangular region. This obviates the need for sensing and communication for collision avoidance among agents. A sufficient upper limit on agent dimensions that ensures collision free motion is derived. An algorithm is developed for choosing the number of agents and optimal Lissajous curve for a prescribed rectangle and agents' sensing capability. The optimal Lissajous curve is chosen to minimize the time period for repeated coverage and maximize the upper bound on agent size. The proposed algorithm is validated through computer simulations and experiments using differential drive robots.
Binding of HIV‐I gp120 to an anti‐V3 loop antibody reveals novel antigen‐induced epitopes

Antigen association to its corresponding binding site in the immunoglobulin molecule can elicit conformational rearrangements, generating novel epitopes termed metatopes. Such metatopes were characterized for the immunocomplex between the AIDS virus envelope protein, gp120, and M77, a mAb directed against the V3 loop. Five novel mAbs were described (GV1, GV3, GV7, GV8, and GV12). These mAbs were found to bind epitopes harbored in the M77 Fab fragment. Binding to the epitopes was shown to require the complexation of Fab with its antigen. The degree of this antigen requirement was found to be variable for the different mAbs and also for the state of IgG fragmentation. Binding of GV12 to its antigen increased the affinity of M77 for gp120. Moreover, in the presence of GV12, M77 acquired extended cross‐reactivity for a second gp120 variant, namely BaL. These results could indicate a novel approach towards improving the performance of anti‐HIV antibodies. —Denisova, G. , Zwickel, J., Gershoni, J. M. Binding of HIV‐I gp120 to an anti‐V3 loop antibody reveals novel antigen‐induced epitopes. FASEB J. 9, 127‐132 (1995)
A Method of Fast and Robust for Traffic Sign Recognition

This paper proposes a fast and robust algorithm for traffic sign detection and recognition. The algorithm includes two stages: traffic sign detection and recognition. In the first stage, Adaboost algorithm based red pixels model of speed limit sign in the Lab color space is built. Then the model is used to extract area of latent speed limit signs. After that, the improved Hough Transform is used to locate the signs precisely. In the second stage, the template matching algorithm is used to recognize the traffic sign. At the same time, a new method of rejecting non-signs is presented, which improved the recognition rate in the complex outdoor scenes.
Ieee Transactions on Pattern Analysis and Machine Intelligence I Using Points at Infinity for Parameter Decoupling in Camera Calibration Ieee Transactions on Pattern Analysis and Machine Intelligence

The majority of camera calibration methods, including the Gold Standard algorithm, use point based information and simultaneously estimate all calibration parameters. In contrast, we propose a novel calibration method that exploits line orientation information and decouples the problem into two simpler stages. We formulate the problem as minimisation of the lateral displacement between single projected image lines and their vanishing points. Unlike previous vanishing point methods, parallel line pairs are not required. Additionally, the invariance properties of vanishing points mean that multiple images related by pure translation can be used to increase the calibration dataset size without increasing the number of estimated parameters. We compare the method with vanishing point methods and the Gold Standard algorithm and demonstrate that it has comparable performance.
Processes and Functions in Higher Education Students Adjusting to a New Learning Environment: Applying The Mmogotm-Method

This article explored the processes and functions amongst a community of students who had to adjust to new social and academic settings. Thirteen university students of a predominantly seTswana ethnic background participated in the study (males = 5, females = 8; age range = 25 to and 45 years). An inductive qualitative research approach was followed by using an expressive projective technique, called the Mmogo™-method. The Mmogo™-method involves the creation of visual representations to get a deeper understanding of the processes and functions that assisted in the adjustment to new social and academic settings. Individual and group discussions were conducted to discuss the visual presentations. Visual data were analysed by means of determining the explicit and implicit meanings elicited in the visual presentations, while the textual data were analysed using thematic content analysis. The students progressed in their construction of interpersonal relational processes for empowerment within the community. Culturally embedded meanings promoted opportunities for optimal participation and engagement in a transforming education system.
Designing a simulator for decentralized SPARQL query processing

We designed a simulator for better simulating decentralized SPARQL query processing at the network level, and for helping evaluating the mechanism. The simulator design aimed to provide a solution to the dilemma in which we were unable to simulate query processing in a decentralized settings and measure its performance at the network level simultaneously in a single simulation run. The original requirement for such design is to evaluate an ad-hoc Semantic Web data sharing system, and we therefore use it as an example to explain how the simulator effectively serves for its intended purpose.
Alcohol involvement among young female drivers in US fatal crashes: unfavourable trends

Objective Young men have greater representation in fatal alcohol-related crashes. Recent studies of young women and risky behaviours have raised concerns about the implications this may have for alcohol-related fatal crashes. The objective of this study was to investigate the representation of young female drivers in US alcohol-involved fatal crashes (1995–2007) and to identify trends heralding future negative changes in crash profiles for young female drivers. Design Fatal crash data were obtained from the US National Highway Traffic Safety Administration Fatal Analysis Reporting System (FARS). Five age groups were analysed. The FARS multiple imputation dataset was used to estimate the proportion of drivers with blood alcohol, and variance estimates were corrected for the procedure. Linear regression was used to measure trends (1995–2007). Results 179 891 fatal crashes in all age groups occurred over the study period. The rate of involvement in fatal crashes for young drivers with positive blood alcohol concentrations (BAC) decreased for men and women aged 16 years but increased for women age 19–24 years. Young female drivers had a greater increase than young men in the proportion of alcohol-involved fatal crashes (3.1%, 95% CI 1.9 to 4.3% vs 1.2%, 95% CI 0.2 to 2.1%, p=0.02). Most of the increase occurred in drivers with BAC ≥0.15 g/dl. Drivers with higher BAC had markedly lower safety restraint use. Over time restraint use increased in all BAC groups studied. Conclusion Alcohol-involved fatal crash rates in young female drivers aged 19–24 years have increased. However, male drivers continue to surpass women in the number of alcohol-involved fatal crashes. Restraint use decreases markedly with increasing BAC.
Gigantic deformable surfaces

From the RLE Sparse Level Set, the Compact RLE Level Set employs a run-length encoding (RLE) scheme that denoted the values of sequential grid points outside of the narrow band by signed runs. The level set values of narrow band grid points are stored explicitly. Taking inspiration from the DT-Grid, the Compact RLE Level Set applies the RLE encoding hierarchically first to the level set values along the x-axis, then to the resulting run codes along the y-axis, and then again to the resulting run codes along the z-axis. Unlike the DT-Grid, our new structure requires the specification of the current maximal bounding box (which can grow arbitrarily as needed to retain the out-of-boxness property.) It is important to note that the Compact RLE Level Set explicitly denotes undefined regions using run codes (which simplifies inside/outside tests in undefined regions), where the DT-Grid only implicitly delineates the undefined regions. Where as the RLE Sparse Level Set requires O(n2 + D) space, where n is the side length of the bounding box and D is the number of defined grid points, our fusion structure only requires O(D) space.
An analytical charge-based compact delay model for submicrometer CMOS inverters

We develop an accurate analytical expression for the propagation delay of submicrometer CMOS inverters that takes into account the short-circuit current, the input-output coupling capacitance, and the carrier velocity saturation effects, of increasing importance in submicrometer CMOS technologies. The model is based on the nth-power-law MOSFET model and computes the delay from the charge delivered to the gate. Comparison with HSPICE level 50 simulations and other previously published models for a 0.18-/spl mu/m and a 0.35-/spl mu/m process technologies show significant improvements over previous models.
[Constant Score and Neer Score. A comparison of score results and subjective patient satisfaction].

INTRODUCTION The Constant- and the Neer-Score are widely used to assess shoulder function after trauma or shoulder diseases. The objective of this study was to compare the correlation of score result with the patient subjective assessment. We hypothesized that there is a clinically relevant difference between the score result and the patient assessment, especially for highly selective patient groups. METHODS 51 patients were followed up after the surgical treatment of a proximal humeral fracture. For each patient the Constant- and the Neer-Score was calculated. Further, the patients were asked for a subjective assessment of their shoulder function ("excellent", "good", "fair", "poor"). RESULTS For both score-systems a good linear correlation (r = 0.97) is shown. 57% of the patients assessed their shoulder function as "excellent" or "good", but only 37% (Constant) vs. 43% (Neer) of the patients were classified as "excellent" or "good" based on their score results. The Spearman correlation of subjective and score-based assessment was just fair with r = 0.50 (Constant) and r = 0.55 (Neer). When comparing the score results with the patient subjective assessment for the groups: "excellent", "good", "fair" and "poor", there was a positive correlation for the Neer-Score in 20 cases and for the Constant-Score in 15 cases. Of all elderly patients (> 60 years, n = 20), 14 (Neer-Score) vs. 16 (Constant-Score) assessed their shoulder function as better than the score did. CONCLUSION The hypothesis of a clinically relevant difference between the subjective and the score-based assessment of shoulder function can be confirmed. Our results suggest that for clinical practice, statements and therapy strategies recommended in the literature, that are just based on score results might not be valid for all patient-groups (e.g. elderly patients).
Timing the bright X-ray population of the core of M31 with XMM-Newton

All 63 discrete X-ray sources brighter than LX=5×10 36 erg s −1 in any of four XMM-Newton observations of the core of M31 were surveyed for time variability over time-scales of seconds to thousands of seconds, and for intensity variations between observations. This population is likely to be dominated by low mass X-ray binaries (LMXBs). Analysis of the shapes of power density spectra (PDS) of these sources allows us to determine whether they are accreting at a high or low rate; in the observed frequency range a broken power law (Type A) PDS indicates a low accretion rate while a simple power law (Type B) indicates a high accretion rate. We obtained the 0.3-10 keV luminosities of the sources by modelling their spectral energy distributions. The luminosity function for Type A PDS appears to consist of two populations, which we tentatively classify as neutron star and black hole LMXBs. We find that 46 sources are likely X-ray binaries, 13 with possible black hole primaries. Remarkably, 4 out of 11 LMXB black hole candidates appear persistently bright over ∼20 years; there are no persistently bright black hole LMXBs known in our Galaxy. The lightcurves of 55 X-ray sources had a probability of variability >99.9% in at least one observation. Also, 57 of the sources show a luminosity variation >5� between observations; 7 of these are classed as transients, since they are absent in at least one observation, and vary in luminosity by a factor of >10. Scaling this sample with the known Galactic LMXBs, we find that the M31 sample has ∼50% of the dippers, Z-sources and transients.
Prevalence and Lifestyle Characteristics of Hypertensive Patients with Metabolic Syndrome Followed at an Outpatient Clinic in Fukuoka, Japan

A new guideline on metabolic syndrome (MS) in Japanese was introduced in 2005. The purpose of this study was to evaluate the prevalence and lifestyle characteristics of Japanese hypertensive patients with MS. Subjects were 290 patients (mean age: 64±11 years) who had been followed at our hospital. The waist circumference (WC) and body mass index (BMI) were assessed. Subjects who had BMI ≥25 kg/m2 were defined as having BMI obesity, while abdominal obesity was defined as a WC ≥85 cm in men and ≥90 cm in women, respectively. Since all patients had hypertension, the definition of MS was made when the patient had abdominal obesity plus either dyslipidemia or glucose intolerance, or both. Among the subjects, 230 patients underwent 24-h home urine collection to measure urinary salt and potassium excretions. Dietary habits were also assessed by use of a questionnaire. Mean values of BMI and WC were 24.2±3.4 kg/m2 and 87.1±9.6 cm, respectively. Among the total subject group, 39% patients were classified as having BMI obesity, 49% as having abdominal obesity, and 27% as having MS. BMI was significantly correlated with WC both in men (r=0.86; p<0.01) and in women (r=0.79; p<0.01). More men than women belonged to the BMI obesity (46% vs. 33%, p<0.05), abdominal obesity (63% vs. 39%, p<0.01) and MS (39% vs. 18%, p<0.01) groups. There were no significant differences in blood pressure between patients with and without MS, while patients with MS needed a greater number of antihypertensive drugs than those without MS. Mean urinary salt and potassium excretions were 8.9±3.8 g/day and 1.9±0.7 g/day, respectively. Urinary salt excretion of <6 g (100 mmol of sodium)/day was achieved in 20% of the subjects. Urinary salt excretion in the patients with MS was significantly higher than that in the patients without (10.1±4.2 vs. 8.5±3.6 g/day; p<0.01). Only 16% of the patients with MS achieved salt restriction (<6 g/day). The patients with MS had a significantly greater the chance to eat out than the patients without MS. They were also less aware of the need to increase their vegetable consumption. The results suggested that MS is prevalent in Japanese hypertensive patients. Patients with MS showed higher urinary salt excretion and needed more antihypertensive drugs to manage their blood pressure. Dietary counseling focusing not only on sodium restriction but also on the need to increase fruit and vegetable consumption seems to be important.
Geometric Ergodicity for diffusions with random regime switching and unbounded rates

Diffusions with random switching are stochastic processes that consist of a diffusion process Xt and a continuous Markov jump process Yt. Both components interact with each other as Yt controls the dynamical regimes of Xt and Xt effects the transition rate of Yt. This type of systems includes a wide range of models used in various fields, and many applications require the transition rates of Yt to be genuinely unbounded due to energy principles. This paper produces concrete criterions for diffusions with random switching to be stable and geometrically ergodic. By integrating a regime based potential into a proper moment of Xt, a locally dissipative Lyapunov function is constructed. Regularized by this Lyapunov function, the joint system (Xt, Yt) is proved to be geometrically ergodic in the total variation norm if the hypoelliptic condition holds for one accessible regime, and geometrically ergodic in a proper Wasserstein distance if the underlying stochastic flow is contracting on average.
Prácticas académicas de profesores de posgrado en el contexto de la era Internet. Estudio de caso: Doctorados Consolidados del PNPC de CONACYT / Academic practices of Post graduate teachers in the context of the Internet age. Case study: Consolidated

En la era de internet la economia basada en el conocimiento esta sujeta a constantes cambios, por lo que la adquisicion de nuevas habilidades y la innovacion tecnologica son vitales para toda sociedad moderna. Este trabajo tiene como proposito senalar que con base en las politicas educativas, en Mexico, los posgrados de calidad, mediados por tecnologias digitales, constituyen una herramienta academica privilegiada para el aprendizaje, la investigacion y la innovacion tecnologica. Desde una perspectiva metodologica de estudio de caso se analizo una nuestra de 22 doctorados consolidados del Programa Nacional de Posgrados de Calidad (PNPC) del CONACYT. Se obtuvo, entre otros resultados relevantes, que en la mayoria de las Instituciones de Educacion Superior (IES), responsables de agenciar dichos programas, las condiciones de infraestructura y equipamiento tecnologico adolecen de serias limitaciones o carencias que van en demerito de brindar a los profesores y estudiantes de posgrados de calidad mejores espacios para un alto rendimiento academico. Lo anterior que constituye un factor negativo en los procesos de formacion de profesionales e investigadores con niveles superiores de competencia que les permita ser competitivos a nivel nacional e internacional.
Educational Achievement in Children: Twinning, Teachers and Genes

ACKNOWLEDGEMENTS We are grateful to the twin families and the teachers for their participation. Twin specific risk factors in primary school achievements Do children perform and behave better at school when taught by same-gender teachers? Genetic Factors Arithmetic, reading and writing performance has a strong genetic component: A study in primary school children A review and meta-analysis of twin studies on educational achievement in primary school highlights the importance of genetic variation Childhood ODD and ADHD behavior: The effect of classroom sharing, gender, teacher gender and their interactions Molecular Genetics and Causality Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children Longitudinal modeling suggests that ADHD symptoms lead to lower educational achievement in children Summary and General Discussion Nederlandse Samenvatting (Dutch Summary)
Protease treatment combined with immunohistochemistry reveals heterogeneity of normal and neoplastic basement membranes.

Heterogeneity of normal tissue and neoplastic basement membranes was investigated immunohistochemically with monoclonal antibodies and polyclonal antisera to laminin and collagen type IV. Cryostat sections of normal and neoplastic human tissues were digested with bacterial protease or trypsin. The duration of digestion and the concentration of enzyme were varied to determine whether laminin and collagen type IV could be removed differentially from basement membranes from distinct anatomic sites. After digestion, the residual antigenicity of glycoprotein was assessed immunohistochemically. Laminin could be removed more easily from all tissues than could collagen IV, and also much more easily from malignant tumors than from benign tumors or normal tissues. On the basis of susceptibility to proteolytic digestion, basement membranes from normal human tissues were classified as susceptible (e.g., heart and smooth muscle of gastrointestinal tract and uterus), moderately resistant (e.g., nerve, skeletal muscle, epithelial basement membrane of skin, smooth muscle of arteries), and very resistant (e.g., glomerulus). Differential susceptibility to proteolytic digestion most likely reflects quantitative and possibly also qualitative differences in the composition of basement membranes.