Miracle-dz/UniFAR-FTUs huggingface dataset:
Effective Capacity Analysis in Ultra-Dense Wireless Networks With Random Interference

Ultra-dense networks (UDNs) provide a promising paradigm to cope with exponentially increasing mobile traffic. However, a little work has to date considered unsaturated traffic with Quality-of-Service (QoS) requirements. This paper presents a new cross-layer analytical model to capture the unsaturated traffic of a UDN in the presence of QoS requirements. The effective capacity (EC) of the UDN is derived, taking into account small-scale channel fading and possible interference. Key properties of the EC are revealed. The amount of traffic impacts EC of the UDN due to the sophisticated interactions among small base stations operating in the same frequency. The maximization of total EC is formulated as a non-cooperative game in this paper. The best-response function is derived, iteratively searching the Nash equilibrium point. System simulation results indicate that our proposed model is accurate. The simulations also show the maximum allowed arrival rate with the QoS guarantee, compared with the full interference model.
Peroxynitrite-mediated vasorelaxation: evidence against the formation of circulating S-nitrosothiols.

Peroxynitrite-induced relaxation of isolated vessels may involve the formation of S-nitrosothiols. This study characterized the hemodynamic effects of systemically injected peroxynitrite in pentobarbital sodium-anesthetized rats and determined whether these effects were due to the formation of S-nitrosothiols. We utilizedl-penicillamine, which attenuates the hemodynamic effects of systemically injected S-nitrosothiols. The hemodynamic effects of peroxynitrite and the S-nitrosothiolsl- S-nitrosocysteine,l- S-nitrosoglutathione, and S-nitrosoalbumin were determined before and 25 min after the administration ofl-penicillamine or saline. Peroxynitrite and the S-nitrosothiols produced dose-dependent reductions in mean arterial pressure and mesenteric and hindquarter vascular resistances. The hypotensive and vasodilator effects of the S-nitrosothiols were significantly reduced by l-penicillamine. In contrast, the hemodynamic actions of peroxynitrite were unaffected byl-penicillamine. Therefore, peroxynitrite produces hypotensive and vasodilator responses in anesthetized rats that are unlikely to be due to the formation of circulating S-nitrosothiols. The mechanisms by which peroxynitrite produces vasodilatation in vivo remain to be determined.
Generation of Induced Pluripotent Stem Cells and Neural Stem/Progenitor Cells from Newborns with Spina Bifida Aperta

Study Design We established induced pluripotent stem cells (iPSCs) and neural stem/progenitor cells (NSPCs) from three newborns with spina bifida aperta (SBa) using clinically practical methods. Purpose We aimed to develop stem cell lines derived from newborns with SBa for future therapeutic use. Overview of Literature SBa is a common congenital spinal cord abnormality that causes defects in neurological and urological functions. Stem cell transplantation therapies are predicted to provide beneficial effects for patients with SBa. However, the availability of appropriate cell sources is inadequate for clinical use because of their limited accessibility and expandability, as well as ethical issues. Methods Fibroblast cultures were established from small fragments of skin obtained from newborns with SBa during SBa repair surgery. The cultured cells were transfected with episomal plasmid vectors encoding reprogramming factors necessary for generating iPSCs. These cells were then differentiated into NSPCs by chemical compound treatment, and NSPCs were expanded using neurosphere technology. Results We successfully generated iPSC lines from the neonatal dermal fibroblasts of three newborns with SBa. We confirmed that these lines exhibited the characteristics of human pluripotent stem cells. We successfully generated NSPCs from all SBa newborn-derived iPSCs with a combination of neural induction and neurosphere technology. Conclusions We successfully generated iPSCs and iPSC-NSPCs from surgical samples obtained from newborns with SBa with the goal of future clinical use in patients with SBa.
Computational Design of Electrode Networks for Preferentially Aligned Short Fiber Composite Component Fabrication via Dielectrophoresis

Finite Element Analysis (FEA) is often used to identify local stress/strain concentrations where a component is likely to fail. In order to reduce the degree of strain concentration, component thickness can be increased in those regions, or a stronger material can be used. In short fiber reinforced composite materials, strength and stiffness can be increased through proper fiber alignment. The field-aided microtailoring (FAiMTa) process is one promising method for doing this. FAiMTa uses principles of dielectrophoresis to preferentially align particles or fibers within a matrix. To achieve the preferred fiber orientation, an interdigitated electrode network must be integrated into the mold halves which can be fabricated by additive manufacturing (AM) processes. However, the process of determining the preferred fiber arrangements and electrode locations can be very challenging. This paper presents algorithms to semi-automate the interdigitated electrode design process. The algorithm has been implemented in the Solidworks CAD system and is demonstrated in this paper.
Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial.

BACKGROUND Mandatory fortification of flour with folic acid has reduced the number of neural tube defects in North America. Concerns that high intakes of folic acid might mask vitamin B-12 deficiency in older persons have delayed the introduction of fortification in many European countries. Cofortification of flour with folic acid and vitamin B-12 could simultaneously improve folate and vitamin B-12 status. OBJECTIVE The objective was to estimate the effect of the consumption of bread fortified with modest amounts of folic acid and vitamin B-12 on folate and vitamin B-12 status in healthy older persons living in the Netherlands, where folic acid fortification is not taking place. DESIGN Men and women aged 50-75 y were randomly assigned in this 12-wk double-blind, placebo-controlled trial to consume bread fortified with 138 mug folic acid and 9.6 mug vitamin B-12 daily (n = 72) or unfortified bread (n = 70). RESULTS The consumption of fortified bread increased serum folate concentrations by 45% (mean: 6.3 nmol/L; 95% CI: 4.5, 8.1 nmol/L) and serum vitamin B-12 concentrations by 49% (mean: 102 pmol/L; 95% CI: 82, 122 pmol/L) relative to the placebo group. Fortified bread increased erythrocyte folate concentrations by 22% and holotranscobalamin concentrations by 35%; it decreased homocysteine concentrations by 13% and methylmalonic acid concentrations by 10%. Consumption of fortified bread decreased the proportion of individuals with marginal serum vitamin B-12 concentrations (<133 pmol/L) from 8% at enrollment to 0% after 12 wk. CONCLUSION Bread fortified with modest amounts of folic acid and vitamin B-12 will improve folate and vitamin B-12 status and a considerable proportion of vitamin B-12 deficiency in older people. This trial was registered at clinicaltrials.gov as NCT00353353.
Practical round-robin differential-phase-shift quantum key distribution

The security of quantum key distribution (QKD) relies on the Heisenberg uncertainty principle, with which legitimate users are able to estimate information leakage by monitoring the disturbance of the transmitted quantum signals. Normally, the disturbance is reflected as bit flip errors in the sifted key; thus, privacy amplification, which removes any leaked information from the key, generally depends on the bit error rate. Recently, a round-robin differential-phase-shift QKD protocol for which privacy amplification does not rely on the bit error rate (Sasaki et al 2014 Nature 509 475) was proposed. The amount of leaked information can be bounded by the sender during the state-preparation stage and hence, is independent of the behavior of the unreliable quantum channel. In our work, we apply the tagging technique to the protocol and present a tight bound on the key rate and employ a decoy-state method. The effects of background noise and misalignment are taken into account under practical conditions. Our simulation results show that the protocol can tolerate channel error rates close to 50% within a typical experiment setting. That is, there is a negligible restriction on the error rate in practice.
Transcriptome Analysis Reveals Molecular Signatures of Luteoloside Accumulation in Senescing Leaves of Lonicera macranthoides

Lonicera macranthoides is an important medicinal plant widely used in traditional Chinese medicine. Luteoloside is a critical bioactive compound in L. macranthoides. To date, the molecular mechanisms underlying luteoloside biosynthesis are still largely unknown. In this work, high performance liquid chromatography (HPLC) was employed to determine the luteoloside contents in leaves, stems, and flowers at different developmental stages. Results showed that senescing leaves can accumulate large amounts of luteoloside, extremely higher than that in young and semi-lignified leaves and other tissues. RNA-Seq analysis identified that twenty-four differentially expressed unigenes (DEGs) associated with luteoloside biosynthesis were significantly up-regulated in senescing leaves, which are positively correlated with luteoloside accumulation. These DEGs include phenylalanine ammonia lyase 2, cinnamate 4-hydroxylase 2, thirteen 4-coumarate-CoA ligases, chalcone synthase 2, six flavonoid 3′-monooxygenase (F3′H) and two flavone 7-O-β-glucosyltransferase (UFGT) genes. Further analysis demonstrated that two F3′Hs (CL11828.Contig1 and CL11828.Contig2) and two UFGTs (Unigene2918 and Unigene97915) might play vital roles in luteoloside generation. Furthermore, several transcription factors (TFs) related to flavonoid biosynthesis including MYB, bHLH and WD40, were differentially expressed during leaf senescence. Among these TFs, MYB12, MYB75, bHLH113 and TTG1 were considered to be key factors involved in the regulation of luteoloside biosynthesis. These findings provide insights for elucidating the molecular signatures of luteoloside accumulation in L. macranthoides.
Using publish/subscribe middleware for mobile systems

The range of mobile computing applications comprises location-based services, sensor networks, and ad hoc networking. Middleware for these applications must effectively support the interaction of a priori anonymous entities, support timely decoupled processing, and mediate between potentially millions of mobile clients. These requirements are hard to achieve with traditional client/server middleware systems. We argue that the publish/subscribe paradigm effectively addresses many of the challenges raised by emerging mobile applications. In this paper, we give an overview of the publish/subscribe paradigm, present a detailed analysis of mobile application requirements, and discuss two proven implementations of this paradigm that address these requirements. We thus show that the publish/subscribe paradigm may effectively address most of the challenges raised by emerging mobile applications.
Non-Alcoholic Fatty Pancreas Disease (NAFPD): A Silent Spectator or the Fifth Component of Metabolic Syndrome? A Literature Review.

BACKGROUND AND OBJECTIVE Fat accumulation in the pancreas has remained a relatively unknown disease since it was initially described in 1926. However, it has gained increasing attention in the past two decades with the emergence of the obesity epidemic. Pancreatic steatosis is a general term used for fat accumulation in the pancreas. It is further classified into fatty replacement, fatty infiltration, lipomatous pseudo-hypertrophy, non-alcoholic fatty pancreas disease (NAFPD) and non-alcoholic fatty steatopancreatitis (NASP). NAFPD is defined as obesity-associated accumulation of fat in the pancreas without significant alcohol consumption. Data on the prevalence of NAFPD are limited due to a lack of standardized screening tests. METHODS MEDLINE/PubMed was searched to find relevant studies and abstracts on pancreatic steatosis. RESULTS Pancreatic fat can be quantified by various imaging techniques including ultrasonography, computed tomography, magnetic resonance imaging and magnetic resonance spectroscopy. The pathophysiology of NAFPD has not been completely understood. Chronic exposure of β-cells to hyperglycemia and higher levels of free fatty acids results in increased intracellular triglyceride accumulation, which ultimately causes reduced insulin secretion, insulin resistance, cell apoptosis and subsequent fatty replacement. This vicious cycle likely is a determining factor in the development of diabetes mellitus and metabolic syndrome. There is no approved pharmacologic therapy for NAFPD. Caloric restriction might have a role in normalization of β-cell function by reducing pancreatic fat content. Troglitazone (blend of telmisartan and sitagliptin) has demonstrated effectiveness in animal models but is still in experimental stages. CONCLUSION The cause and effect relationship between the metabolic syndrome and NAFPD has not yet been established. Further studies are required to study the effect of NAFPD on glucose hemostasis.
Effects of nano α-Al2O3 fillers and dispersant on thermal and dynamic mechanical properties of polypropylene/nano α-Al2O3 composite

This article presents a comparative study on the effects of nano α-alumina on thermal degradation and dynamic mechanical properties of polypropylene (PP) nanocomposites. In this respect, two types of composites were prepared, with dispersant and without dispersant. Thermogravimetric analysis of both composites showed a drastic shift in the weight loss curve toward higher temperature, which led to reduction in the PP heat release rate in both composites. Differential scanning calorimetry results showed that the crystallinity of the nanocomposites was increased especially in the presence of dispersant. The storage modulus of the nanocomposites was found to be higher than that of pure PP, because nanofiller increased the stiffness of the nanocomposites. The glass transition temperatures of the nanocomposites were not significantly changed and damping factor of the nanocomposites was decreased.
Proteobacteria and Bacteroidetes are major phyla of filterable bacteria passing through 0.22 μm pore size membrane filter, in Lake Sanaru, Hamamatsu, Japan

Abstract 141 filterable bacteria that passed through a 0.22 μm pore size filter were isolated from Lake Sanaru in Hamamatsu, Japan. These belonged to Proteobacteria, Bacteroidetes, Firmicutes, or Actinobacteria among which the first two phyla comprised the majority of the isolates. 48 isolates (12 taxa) are candidates assignable to new bacterial species or genera of Proteobacteria or Bacteroidetes.
Hydrodynamics in inner airlift reactor with external liquid circulation

The profiles of gas holdup and bubble velocity depending on superficial gas velocity were investigated in an inner airlift reactor with a down tube and an annulus gas distributor.The experimental set-up was made of plexiglass with an inner diameter of 0.286 m and a height of 3.0 m.Air and tap water were used as gas and liquid phases,respectively.The results showed that the gas holdup increased with increasing superficial gas velocity within both inner and outer loops.The gas holdup in the inner loop,however,was much higher than that in the outer loop.The bubbles entering the inner loop from the outer loop could be neglected in the ranges of the operating conditions.When an annulus gas distributor and a down tube were installed in the conventional airlift reactor,the gas holdup increased and its distribution became uniform,which enhanced the interfacial area between gas and liquid phases and the turbulent intensity of multiphase flow.Therefore,the interphase transfer would be improved in the inner loop.Then,the profiles of gas holdup and bubble velocity were simulated by using the Euler-Euler model in the platform of ANSYS CFX10.0 software package and fair agreement between numerical and experimental data was obtained.These results implied that the CFD simulation based on the Euler-Euler model,accompanied with experimental measurement,could be used to develop and scale up this new kind of loop reactor.
Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins.

After the simulation of anoxia by ATP depletion of MDCK cell monolayers with metabolic inhibitors, the tight junction (TJ) is known to become structurally perturbed, leading to loss of the permeability barrier. Peripheral TJ proteins such as zonula occludens 1 (ZO-1), ZO-2, and cingulin become extremely insoluble and associate into large macromolecular complexes (T. Tsukamoto and S. K. Nigam. J. Biol. Chem. 272: 16133-16139, 1997). For up to 3 h, this process is reversible by ATP repletion. We now show that the reassembly process depends on tyrosine phosphorylation. Recovery of transepithelial electrical resistance in ATP-replete monolayers was markedly inhibited by the tyrosine kinase inhibitor, genistein. Indirect immunofluorescence revealed a decrease in staining of occludin, a membrane component of the TJ, in the region of the TJ after ATP depletion, which reversed after ATP repletion; this reversal process was inhibited by genistein. Examination of the Triton X-100 solubilities of occludin and several nonmembrane TJ proteins revealed a shift of occludin and nonmembrane TJ proteins into an insoluble pool following ATP depletion. These changes reversed after ATP repletion, and the movement of insoluble occludin, ZO-1, and ZO-2 back into the soluble pool was again via a genistein-sensitive mechanism. Rate-zonal centrifugation analyses of detergent-soluble TJ proteins showed a reversible increase in higher density fractions following ATP depletion-repletion, although this change was not affected by genistein. In32P-labeled cells, dephosphorylation of all studied TJ proteins was observed during ATP depletion, followed by rephosphorylation during ATP repletion; rephosphorylation of occludin was inhibited by genistein. Furthermore, during the ATP repletion phase, tyrosine phosphorylation of Triton X-100-insoluble occludin, which is localized at the junction, as well as ZO-2, p130/ZO-3 (though not ZO-1), and other proteins was evident; this tyrosine phosphorylation was completely inhibited by genistein. This indicates that tyrosine kinase activity is necessary for TJ reassembly during ATP repletion and suggests an important role for the tyrosine phosphorylation of occludin, ZO-2, p130/ZO-3, and possibly other proteins in the processes involved in TJ (re)formation.
A coral‐reef optimization algorithm for the optimal service distribution problem in mobile radio access networks

Mobile technology is currently one of the main pillars of worldwide economy. The constant evolution that mobile communications have undergone in the last decades, due to the appearance of new services and new technologies such as Universal Mobile Telecommunication Systems/High Speed Data Access and Long Term Evolution, has contributed to achieve this position in global economy. However, because of the crisis of the sector in the last 5 years, mobile operator's revenues and investments have been reduced. Thus, mobile network operators tend to exploit the existing infrastructure at maximum possible, trying to use the existing network in the most efficient way. In this paper, a novel bio‐inspired algorithm, the coral reef optimization algorithm (CRO) is introduced to minimise a network deployment investment cost problem. This is carried out by means of optimising the user demand of different services offered by mobile operators over the available technologies in the market, namely the optimal service distribution problem. The CRO is a recently proposed meta‐heuristic based on the computer simulation of corals reproduction and reefs’ formation. In this paper, this algorithm has been tested on several optimal service distribution problem scenarios in Spain, observing a significant reduction (up to 400 M€) on the total investment costs associated to the radio access network deployment. We compare the performance of the CRO approach with that of a classical (experience‐based) services distribution, and with alternative meta‐heuristics techniques, obtaining good results in all cases. Copyright © 2013 John Wiley & Sons, Ltd.
Ethanol dissociates hormone-stimulated cAMP production from inhibition of TNF-α production in rat Kupffer cells.

Ethanol impairs hormone-stimulated cAMP production in a number of cell types, yet the effects of ethanol on downstream responses mediated by cAMP-dependent protein kinase (PKA) are not understood. Here we have investigated the effects of ethanol feeding on cAMP-mediated inhibition of tumor necrosis factor-α (TNF-α) synthesis in rat Kupffer cells. Male Wistar rats were fed liquid diets containing 36% of calories as ethanol for 4 wk or were pair fed a control diet. Stimulation of cAMP production by the adenosine A2receptor agonist 5'-( N-ethylcarboxamido)-adenosine (NECA), prostaglandin E2, or forskolin was decreased to 25% of control values in Kupffer cells isolated from ethanol-fed rats. This decrease was associated with a reduction in the quantity of immunoreactive Gsα protein in ethanol-fed rats, with no changes observed in Giα or Gβ. TNF-α production was higher in ethanol-fed rats in response to stimulation with lipopolysaccharide or latex beads. Despite the profound reduction in the ability of hormone to increase cAMP production, NECA and prostaglandin E2 inhibited TNF-α production to an equivalent degree in Kupffer cells from ethanol- and pair-fed rats. Total activity and immuoreactive protein quantity of PKA did not differ between groups. Activation of PKA in response to a 15-min treatment with 1 μM NECA was reduced by 50% in ethanol-fed rats compared with control. Despite this reduction in activation, translocation of the catalytic subunit of PKA to the nucleus and phosphorylation of cAMP response element binding protein in response to activation were observed in Kupffer cells from both ethanol- and pair-fed rats. These data demonstrate that there is a dissociation between ethanol-induced desensitization of hormone-stimulated cAMP production in rat Kupffer cells and the downstream inhibition of TNF-α production mediated by cAMP.
Rule Management System for Ontology-based Recommendation System

Rule management system was developed in order to provide a facility for domain experts to pass on their knowledge in rule-based format, by means of ontology concepts. Experts can utilize this system via web application, developed by deploying JSP and servlet technology. The web application contains the internal functions for dealing with ontology, database and rule file by deploying the JAVA language for which several APIs are available. One of JAVA APIs which the author employed is Jena API. Additionally, experts have ability to manage the rules such as writing new rule item, modifying the existing rules, removing the rules and so on. Author provides the tool that can assist experts to manage rules conveniently. For example, displaying the filtered results in the format of autocomplete, converting the filling data to make human-readable and rules repository can be done within rule file in the format of SPARQL syntax. Rules can be classified into four distinctive formats: messaging, instance insertion, instance creation, information search respectively. Besides, the web application has the capability of displaying the rule effect and information recommendation. KeywordsOntology, SPARQL, recommendation system and rule management system