Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhancement of nano-hydroxyapatite bonding to dentin through a collagen/calcium dual-affinitive peptide for dentinal tubule occlusion

Calcium phosphate crystals, as the main component of dentin and enamel, have been widely used for the occlusion of dentinal tubules. However, the low bond strength and poor sealing effect limit their clinical practicality. In this study, a collagen/calcium dual-affinitive peptide E8DS (EEEEEEEEDSpESpSpEEDR) and nano-hydroxyapatite (nano-HAp) flocculi were developed to seal dentin tubules for reducing dentin hypersensitivity, whereas the E8DS peptides were pre-applied to improve the adhesion of occlusive hydroxyapatite coating on dentin collagen matrix for the long-lasting sealing effect and relief from hypersensitivity. Our study showed that E8DS peptides had a strong affinity with dentin collageneous matrix that almost 43.7% of initial E8DS peptides immobilized on exposed dentin samples remained detained after continuous washing by distilled water for four weeks at a rate of 1 mL/min. Nano-HAp flocculi were obtained by re-neutralization of HAp-HCl solution and then brushed onto the surfaces of pre-treated human dentin disks with E8DS peptides, which showed a perfect occlusion of exposed dentinal tubules, as compared with Nano-HAp only and a commercial desensitizer, Green Or. With only around 10-min E8DS peptide pre-treatment, the occlusive mineral layers remained intact against consecutively stirred washing in phosphate-buffered saline or coke for 15 min, and 6 min of tooth-brushing, which implied that our E8DS peptide could comparatively improve the durability of sealant-dentin interface bonds for long-lasting dentine desensitization.
New 3D-scroll attractors in hyperchaotic Chua's Circuits Forming a Ring

This paper presents an approach for generating new hyperchaotic attractors in a ring of Chua's circuits. By taking a closed chain of three circuits and exploiting sine functions as nonlinearities, the proposed technique enables 3D-scroll attractors to be generated. In particular, the paper shows that 3D-scroll dynamics can be designed by modifying six parameters related to the circuit nonlinearities.
Alcohol use disorders identification test has bias

EDITOR—In the brave new world of a National Health Service where value for money is tantamount, Coulton et al are to be commended for using several valid clinical outcome measures for alcohol misuse and dependence and comparing them with more traditional biochemical variables commonly used in both primary and secondary care.1 However, some caution …
Computer assisted plant identification system for Android

Plant leaves provide sufficient features to distinguish them among other species. Identification of plants using leaf images is a classic problem in digital image processing. Usually those image processing systems use shape based digital morphological features for leaf identification task. Even there are number of studies on leaf based plant identification, very few of them are for mobiles. In this paper we describe a leaf image based plant identification system using SIFT features combining with Bag Of Word (BOW) model and Support Vector Machine (SVM) classifier. The system is trained to classify 20 species and obtained 96.48 % accuracy level. Based on the results, we developed an Android application communicates with the server and gives users the ability to identify plant species using photographs taken of plant leaves using the smart phone.
Polish forum for prevention guidelines on metabolic syndrome.

1 Coordinator of the PFP Guidelines on Metabolic Syndrome 2 Chairman of the PFP Task Force on Guidelines 3 Secretary of the PFP Task Force on Guidelines 4 Member of the PFP Task Force on Guidelines (Polish Society of Hypertension) 5 Expert of the PFP Task Force on Guidelines (Polish Cardiac Society) 6 Member of the PFP Task Force on Guidelines (Polish Pediatric Society) 7 Member of the PFP Task Force on Guidelines (Polish Society of Internal Medicine) 8 Member of the PFP Task Force on Guidelines (The College of Family Physicians in Poland) 9 Member of the PFP Task Force on Guidelines (Polish Diabetes Society) 10 Member of the PFP Task Force on Guidelines (Polish Cardiac Society) 11 Member of the PFP Task Force on Guidelines (Polish Society for Atherosclerosis Research) 12 Member of the PFP Task Force on Guidelines (Polish Society of Neurology) 13 Expert of the PFP on Metabolic Syndrome (Polish Diabetes Society) 14 PFP Coordinator 2009 (The College of Family Physicians in Poland)
Diabetic Foot Ulcers and Infections: Current Concepts

PURPOSE To offer an educational experience that will help improve the participant's understanding of diabetic foot ulcers and infections. TARGET AUDIENCE This CME/CE activity is intended for physicians and nurses with an interest in the prevention and treatment of diabetic foot ulcers and infections. LEARNING OBJECTIVESDescribe the factors that put a diabetic patient's foot at risk for ulceration.Identify the components of optimal treatment of diabetic foot ulcers.Explain the roles of vascular and orthopaedic surgery in the treatment of diabetic foot ulcers and infections.
Mechanisms Shaping the Slow Nicotinic Synaptic Current at the Motoneuron–Renshaw Cell Synapse

In spinal cord slices from newborn mice we have analyzed the kinetics of the EPSCs mediated by heteromeric nicotinic receptors at the motoneuron–Renshaw cell (MN-RC) synapse. The miniature EPSCs decay with a time constant of 13.0 ± 1.1 ms whereas the decay of the evoked EPSCs (eEPSCs) is biphasic, with time constants of 15.6 ± 0.8 and 124.8 ± 9.0 ms. The slow component becomes prominent during a repetitive stimulation, but its time constant is unchanged. It is selectively reduced by the addition of acetylcholinesterase (AChE), and thus appears to involve ACh spillover. The constancy of the slow time constant during a train is best explained by a local spillover activating high-affinity receptors. In many cells a fraction of the eEPSC originates in neighboring RCs and is transmitted by the low-pass filter of the gap junctions. The component transmitted electrically can be eliminated by meclofenamic acid, a blocker of gap junctions. The local spillover produced by a repetitive stimulation was compared with the long-range spillover produced by inactivation of AChE. The pharmacological inactivation of AChE by neostigmine caused the appearance of an ultra-slow (second range) decay component in eEPSCs and also a continuous inward current interpreted as resulting from a continuous ACh presence. In animals lacking functional AChE in the CNS (PRiMA−/− mice) the EPSCs resembled those observed in neostigmine but the steady inward current was much smaller, suggesting an adaptation to the absence of AChE.
TIME‐DEPENDENT SPECIATION AND EXTINCTION FROM PHYLOGENIES: A LEAST SQUARES APPROACH

Molecular phylogenies contribute to the study of the patterns and processes of macroevolution even though past events (fossils) are not recorded in these data. In this article, I consider the general time‐dependent birth–death model to fit any model of temporal variation in speciation and extinction to phylogenies. I establish formulae to compute the expected cumulative distribution function of branching times for any model, and, building on previous published works, I derive maximum likelihood estimators. Some limitations of the likelihood approach are described, and a fitting procedure based on least squares is developed that alleviates the shortcomings of maximum likelihood in the present context. Parametric and nonparametric bootstrap procedures are developed to assess uncertainty in the parameter estimates, the latter version giving narrower confidence intervals and being faster to compute. I also present several general algorithms of tree simulation in continuous time. I illustrate the application of this approach with the analysis of simulated datasets, and two published phylogenies of primates (Catarrhinae) and lizards (Agamidae).
Partial Order Interpretation of a Mu-Calculus-Like Temporal Logic

: In this paper, we interpret a temporal logic over a partial order model that is a trace system. Our focus is two fold: (i) to deﬁne the satisfaction of the formulae directly on traces, so completely avoiding graph representations, while maintainig the trace system ﬁnite, also in presence of inﬁnite computations; (ii) to reduce the complexity of model checking temporal logic formula, deﬁning an abstraction technique applied to trace systems.
Recovery in Canada: Toward social equality

Abstract This article reviews evolution of the recovery paradigm in Canadian mental health. We first trace the origins and development of the recovery concept through the literature, followed by an examination of how the recovery concept has been implemented in national and provincial mental health policy since publication of the 2006 Kirby Commission Report. Based on consultations with Canadian policymakers, and an examination of available policy documents, we explore how the dual theme of ‘recovery’ and ‘well-being’, adopted by the Mental Health Commission of Canada in its 2009 strategy: Toward Recovery and Well-being - A Framework For a Mental Health Strategy has subsequently played out in mental health policymaking at the provincial level. Findings reveal mixed support for recovery as a guiding principle for mental health reform in Canada. While policies in some provinces reflect widespread support for recovery, and strong identification with the aspirations of the consumer movement; other provinces have shifted to population-based, wellness paradigms that privilege evidence-based services and professional expertise. The recognition of social equality for people who experience mental illness emerges as an important value in Canadian mental health policy, cutting across the conceptual divide between recovery and well-being.
Joint analysis of longitudinal feed intake and single recorded production traits in pigs using a novel Horizontal model.

A novel Horizontal model is presented for multitrait analysis of longitudinal traits through random regression analysis combined with single recorded traits. Weekly ADFI on test for Danish Duroc, Landrace, and Yorkshire boars were available from the national test station and were collected from 30 to 100 kg BW. Single recorded production traits of ADG from birth to 30 kg BW (ADG30), ADG from 30 to 100 kg BW (ADG100), and lean meat percentage (LMP) were available from breeding herds or the national test station. The Horizontal model combined random regression analysis of feed intake (FI) with single recorded traits of ADG100, LMP, and ADG30. In the Horizontal model, the FI data were horizontally structured with FI on each week as a "trait. " The additive genetic and litter effects were modeled to be common across different FI records by reducing the rank of the covariance matrices using second- and first-order Legendre polynomials of age on test, respectively. The fixed effect and random residual variance were estimated for each weekly FI trait. Residual feed intake (RFI) was derived from the conditional distribution of FI given the breeding values of ADG100 and LMP. The heritability of FI varied by week on test in Duroc (0.12 to 0.19), Landrace (0.13 to 0.22), and Yorkshire (0.21 to 0.23). The heritability of RFI was lowest and highest in wk 6 (0.03) and 10 (0.10), respectively, in Duroc and wk 7 (0.04 and 0.02) and 1 (0.09 and 0.20), respectively, in Landrace and Yorkshire. The proportion of FI genetic variance explained by RFI ranged from 20 to 75% in Duroc, from 19 to 75% in Landrace, and from 11 to 91% in Yorkshire. Average daily gain from 30 to 100 kg BW and ADG30 heritabilities were moderate in Duroc (0.24 and 0.22, respectively), Landrace (0.34 and 0.25, respectively), and Yorkshire (0.34 and 0.22, respectively). Lean meat percentage heritability was moderate in Duroc (0.37) and large in Landrace (0.62) and Yorkshire (0.60). The genetic correlation of FI with ADG100 increased by week on test followed by a 32% decrease from wk 7 in Duroc and a 7% decrease in dam line breeds. Defining RFI as genetically independent of production traits leads to consistent and easy interpretable breeding values. The genetic parameters of traits in the feed efficiency complex and their dynamics over the test period showed breed differences that could be related to the fatness and growth potential of the breeds. The Horizontal model can be used to simultaneously analyze repeated and single recorded traits through proper modeling of the environmental variances and covariances.
Directional disorder of ciliary metachronal waves using two-dimensional correlation map

The interrelationship of cilia and the order of wave directions are important factors that determine the effectiveness of cilia to transport materials in mucociliary systems of the respiratory tract. The interrelationship of cilia and the directional disorder of the ciliary metachronal wave were analyzed using digital microscopic images. The degree of synchronization between ciliary beats was determined by the correlation factor between two different spots. To find out the uniphase directions of beating cilia, principal axes of inertia were applied to the two-dimensional correlation map calculated from sequential ciliary images. The standard deviation of determined wave directions in a region of interest (ROI) was defined as a measure of metachronal wave disorder. The pooled mean of metachronal wave disorder was 23.4 /spl plusmn/ 8.79/spl deg/ in ROIs of 8 /spl mu/m /spl times/ 8 /spl mu/m and 25.4 /spl plusmn/ 6.46/spl deg/ in 32 /spl mu/m /spl times/ 24 /spl mu/m from the sphenoid sinus mucosa of five normal subjects. Our result shows that there is a considerable variation in metachronal wave directions of cilia beating on the epithelium.
The utilization of glucose and proline by culture forms of Trypanosoma brucei.

SYNOPSIS Exponentially dividing culture forms of Trypanosoma brucei did not utilize glucose provided in the culture medium. The inclusion of 2-deoxyglucose in the medium had no effect on the growth of the trypanosomes. Glucose could be replaced by proline in the liquid phase of biphasic medium without affecting the doubling time of the organisms. Proline added to the culture medium in this way disappeared during the log phase of growth. Glucose in the culture medium was used by the trypanosomes only when the stationary growth phase had been reached. Lipid accumulated in stationary phase trypanosomes grown in glucose-containing medium, but there was no lipid accumulation in log phase organisms or in those which had been grown in proline-containing medium. Bloodstream trypanosomes transferred to liquid medium rapidly utilized glucose over the first 12 hr of culture, and this was accompanied by an accumulation of free pyruvate in the medium. The rate of glucose utilization fell off over the next 36 hr; this was accompanied by a lowering of free pyruvate in the medium and a rise in the proline oxidase activity of the trypanosomes. The possible biologic significance of proline to trypanosomes developing in the midgut of the tsetse vector is discussed.
Time evolution within a comoving window: scaling of signal fronts and magnetization plateaus after a local quench in quantum spin chains

We present a modification of Matrix Product State time evolution to simulate the propagation of signal fronts on infinite one-dimensional systems. We restrict the calculation to a window moving along with a signal, which by the Lieb–Robinson bound is contained within a light cone. Signal fronts can be studied unperturbed and with high precision for much longer times than on finite systems. Entanglement inside the window is naturally small, greatly lowering computational effort. We investigate the time evolution of the transverse field Ising (TFI) model and of the S = 1/2 XXZ antiferromagnet in their symmetry broken phases after several different local quantum quenches. In both models, we observe distinct magnetisation plateaus at the signal front for very large times, resembling those previously observed for the particle density of tight binding (TB) fermions. We show that the normalised difference to the magnetisation of the ground state exhibits similar scaling behaviour as the density of TB fermions. In the XXZ model there is an additional internal structure of the signal front due to pairing, and wider plateaus with tight binding scaling exponents for the normalised excess magnetisation. We also observe parameter dependent interaction effects between individual plateaus, resulting in a slight spatial compression of the plateau widths. In the TFI model, we additionally find that for an initial Jordan–Wigner domain wall state, the complete time evolution of the normalised excess longitudinal magnetisation agrees exactly with the particle density of TB fermions.
Error control coding : fundamentals and applications

1. Coding for Reliable Digital Transmission and Storage. 2. Introduction to Algebra. 3. Linear Block Codes. 4. Important Linear Block Codes. 5. Cyclic Codes. 6. Binary BCH Codes. 7. Nonbinary BCH Codes, Reed-Solomon Codes, and Decoding Algorithms. 8. Majority-Logic Decodable Codes. 9. Trellises for Linear Block Codes. 10. Reliability-Based Soft-Decision Decoding Algorithms for Linear Block Codes. 11. Convolutional Codes. 12. Trellis-Based Decoding Algorithms for Convolutional Codes. 13. Sequential and Threshold Decoding of Convolutional Codes. 14. Trellis-Based Soft-Decision Algorithms for Linear Block Codes. 15. Concatenated Coding, Code Decomposition ad Multistage Decoding. 16. Turbo Coding. 17. Low Density Parity Check Codes. 18. Trellis Coded Modulation. 19. Block Coded Modulation. 20. Burst-Error-Correcting Codes. 21. Automatic-Repeat-Request Strategies.
Words That Move Us. The Effects of Sentences on Body Sway

According to the embodied cognition perspective, cognitive systems and perceptuo-motor systems are deeply intertwined and exert a causal effect on each other. A prediction following from this idea is that cognitive activity can result in subtle changes in observable movement. In one experiment, we tested whether reading various sentences resulted in changes in postural sway. Sentences symbolized various human activities involving high, low, or no physical effort. Dutch participants stood upright on a force plate, measuring the body center of pressure, while reading a succession of sentences. High physical effort sentences resulted in more postural sway (greater SD) than low physical effort sentences. This effect only showed up in medio-lateral sway but not anterio-posterior sway. This suggests that sentence comprehension was accompanied by subtle motoric activity, likely mirroring the various activities symbolized in the sentences. We conclude that semantic processing reaches the motor periphery, leading to increased postural activity.
Investigating Follow-Up Outcome Change Using Hierarchical Linear Modeling

Individual change in outcome during a one-year follow-up period for 98 patients who received either interpretive or supportive psychotherapy was examined using hierarchical linear modeling (HLM). This followed a previous study that had investigated average (treatment condition) change during follow-up using traditional methods of data analysis (repeated measures ANOVA, chi-square tests). We also investigated whether two patient personality characteristics-quality of object relations (QOR) and psychological mindedness (PM)-predicted individual change. HLM procedures yielded findings that were not detected using traditional methods of data analysis. New findings indicated that the rate of individual change in outcome during follow-up varied significantly among the patients. QOR was directly related to favorable individual change for supportive therapy patients, but not for patients who received interpretive therapy. The findings have implications for determining which patients will show long-term benefit following short-term supportive therapy and how to enhance it. The study also found significant associations between QOR and final outcome level.
Computing Toric Ideals

Toric ideals are binomial ideals which represent the algebraic relations of sets of power products. They appear in many problems arising from different branches of mathematics. In this paper, we develop new theories which allow us to devise a parallel algorithm and an efficient elimination algorithm. In many respects they improve existing algorithms for the computation of toric ideals.
Evaluation and Comparison of Various PCR Methods for Detection of Mycoplasma gallisepticum Infection in Chickens

Abstract Four generic Mycoplasma gallisepticum (MG) polymerase chain reactions (PCRs) (16S rRNA PCR, three newly developed PCR methods that target surface protein genes [mgc2, LP (nested) and gapA (nested)]) were compared for analytical specificity and sensitivity and for diagnostic sensitivity (Se) and specificity of detection from tracheal swabs. The licensed MG DNA Test Kit Flock Chek test (IDEXX, Laboratories, Inc., Westbrook, ME) was as well evaluated for the diagnostic specificity and sensitivity of detection from tracheal swabs. Analytical specificity was evaluated for the four generic PCR methods using a panel of DNA samples from microorganisms that may be isolated from the trachea of commercial poultry and other fowl. PCR methods mgc2, nLP, and ngapA only amplified DNA from MG, whereas 16S rRNA PCR amplified DNA from MG and Mycoplasma imitans. The analytical sensitivity of the four generic PCR methods expressed in color-changing units (CCU)/amplification reaction was estimated for each PCR method and ranged from 4 to 400 CCU/reaction; the sensitivities of single PCR methods 16S rRNA and mgc2 were estimated at 40 CCU/reaction, the nLP at 400 CCU/reaction, and the ngapA at 4 CCU/reaction. The diagnostic sensitivity and specificity of MG detection from tracheal swab pools, as compared to isolation from choanal cleft swabs, was evaluated for the five PCR methods using three groups of birds exposed to vaccine strains ts-11 and 6/85 and to challenge strain R. All PCR methods were able to detect the vaccine strains and the challenge strain R directly from tracheal swabs, indicating that PCR primers from the different methods amplified divergent MG strains. Isolation and PCR results correlated satisfactorily among the three experimentally infected groups, with agreement values (k) ranging from 0.52 to 1.00. The ngapA, IDEXX, and mgc2 PCRs showed the best sensitivity (Se) ratios for detection of M. gallisepticum strains as compared to isolation. Compared to the ngapA and IDEXX PCR methods, the mgc2 PCR has a faster turnaround time, since this test consists of a single amplification reaction and the amplification product is detected by gel electrophoresis. Therefore, among the PCR methods evaluated in this study, the mgc2 PCR is the method of choice to further validate in the field.
Genetic targeting of microglia

Genetic targeting of microglia and other myeloid cells in the central nervous system (CNS) is highly desirable as they are critical effectors and regulators of changes in CNS homeostasis during development as well as in health and disease. Therefore, genetic reprogramming of microglia could constitute a central approach for potentially reducing disease burden. Previous attempts to target only microglia in vivo failed because of the similarities to their hematopoietic relatives in the circulation. However, this concept has been challenged by recent results of developmental and gene expression profiling studies which used novel molecular biological tools to unravel the origin of microglia and to define their role as specialized tissue macrophages clearly distinct from monocytes or monocyte‐derived macrophages. The aim of this review is to recapitulate the history of microglia targeting approaches and finally highlight recent achievements in the field. We will discuss the pros and cons of the newly available genetic tools, their potential for future microglia research and genetic strategies. GLIA 2015;63:1–22