Miracle-dz/UniFAR-FTUs huggingface dataset:
[Evaluation of hospitalization period and five-year follow-up of patients admitted with acute coronary syndrome following coronary artery bypass graft surgery].

OBJECTIVES We evaluated patients admitted with the diagnosis of acute coronary syndrome (ACS) after coronary artery bypass graft (CABG) surgery. STUDY DESIGN This retrospective study included 72 consecutive CABG patients (10 women, 62 men; mean age 63±9 years; range 45 to 83 years). Acute coronary syndrome was defined as the presence of unstable angina or myocardial infarction (MI) with or without ST elevation. Time from CABG surgery to admission with ACS was defined as bypass age. Following discharge, information was derived by phone calls from the patients or relatives on cardiovascular events within a five-year period. RESULTS On admission, 14 patients (19.4%) had non-ST elevation MI, nine patients (12.5%) had ST elevation MI, and 49 patients (68.1%) had unstable angina. The mean bypass age was 5.6±3.5 years. Of the study group, 38.9% were obese, 25% were diabetic, 54.2% were hypertensive, 44.4% were hyperlipidemic, and 26.4% were current smokers. Medications before admission included aspirin (81.9%), statin (25%), beta-blocker (27.8%), ACE inhibitor or angiotensin receptor blocker (27.8%), and calcium channel antagonist (36.1%). Increased LDL cholesterol (≥100 mg/dl) and decreased HDL cholesterol (≤50 mg/dl) levels were present in 55.6% and 80.6%, respectively. Mortality occurred in 15 patients, four during hospitalization, and 11 after discharge. The overall mortality rate was 21.4%. In correlation analysis, mortality was positively correlated with age (r=0.34, p=0.005), bypass age (r=0.37, p=0.001), CRP level (r=0.31, p=0.033) and negatively correlated with beta-blocker use (r=-0.25, p=0.041) and ejection fraction (r=-0.37, p=0.016). CONCLUSION Our results show that, following CABG surgery, special consideration should be given to risk factor management and use of agents with proven effects against cardiovascular mortality such as statins, beta-blockers, and ACE inhibitors.
Contextual localization through network traffic analysis

The rise of location-based services has enabled many opportunities for content service providers to optimize the content delivery based on user's location. Since sharing precise location remains a major privacy concern among the users, many location-based services rely on contextual location (e.g. residence, cafe etc.) as opposed to acquiring user's exact physical location. In this paper, we present PACL (Privacy-Aware Contextual Localizer), which can learn user's contextual location just by passively monitoring user's network traffic. PACL can discern a set of vital attributes (statistical and application-based) from user's network traffic, and predict user's contextual location with a very high accuracy. We design and evaluate PACL using real-world network traces of over 1700 users with over 100 gigabytes of total data. Our results show that PACL (built using decision tree) can predict user's contextual location with the accuracy of around 87%.
Identifying viral parameters from in vitro cell cultures

Current in vitro cell culture studies of viral replication deliver detailed time courses of several virological variables, like the amount of virions and the number of target cells, measured over several days of the experiment. Each of these time points solely provides a snap-shot of the virus infection kinetics and is brought about by the complex interplay of target cell infection, and viral production and cell death. It remains a challenge to interpret these data quantitatively and to reveal the kinetics of these underlying processes to understand how the viral infection depends on these kinetic properties. In order to decompose the kinetics of virus infection, we introduce a method to “quantitatively” describe the virus infection in in vitro cell cultures, and discuss the potential of the mathematical based analyses for experimental virology.
Trend detection model

This paper presents a topic model that detects topic distributions over time. Our proposed model, Trend Detection Model (TDM) introduces a latent trend class variable into each document. The trend class has a probability distribution over topics and a continuous distribution over time. Experiments using our data set show that TDM is useful as a generative model in the analysis of the evolution of trends.
Sport, Culture and Ideology

Sport, Culture and Ideology (RLE Sports Studies)-Jennifer Hargreaves 2014-04-24 Sport celebrates basic human values of freedom, justice and courage. This collection of essays probes beneath those assumptions in order to illuminate how sport is intimately related to power and domination. Topics include the media treatment of sport, drug-taking in sport and the controversial and problematic relationship between sport and politics in Russia and South Africa.
Telomerase in relation to clinicopathologic prognostic factors and survival in cervical cancer

We investigated, in cervical cancer, the relation between telomerase activity, telomerase RNA (hTR) and mRNA of the catalytic subunit of telomerase, hTERT, with “classic” clinicopathological factors as well as survival. Frozen specimens were obtained from 107 consecutive patients with cervical cancer, treated with surgery or radiotherapy with or without chemotherapy. Telomerase activity was determined with fluorescence‐based TRAP and hTR and hTERT with semi‐quantitative RT‐PCR. Eight normal cervical specimens served as controls. Analysis of prognostic factors and survival was limited to early‐stage patients, treated primarily with radical hysterectomy. Telomerase activity was not detected in normal cervices and was present in 85 of 107 (79%) cervical cancers (p < 0.001). hTR was detected in all normal cervices and cervical cancers, while hTERT mRNA was detected in 1 of 8 (13%) normal cervices and in 83 of 104 (80%) cervical cancers (p < 0.001). In contrast to semi‐quantitative hTR expression levels, semi‐quantitative hTERT mRNA levels were related to telomerase activity levels (p < 0.01). In all patients, telomerase activity levels were related to differentiation grade (p < 0.05) but not to stage and histotype. In early‐stage patients, telomerase activity, hTR and hTERT were not related to tumor volume, vascular invasion or presence of metastatic lymph nodes. Tumor volume, vascular invasion and presence of metastatic lymph nodes were related to (progression‐free) survival, while telomerase activity and its subunits were not. Frequent up‐regulation of telomerase activity and hTERT mRNA is especially observed in cervical cancers, while hTR is also detected in normal cervices. Telomerase is not applicable as a prognostic factor in early‐stage cervical cancer patients. © 2001 Wiley‐Liss, Inc.
The cell adhesion molecules Echinoid and Friend of Echinoid coordinate cell adhesion and cell signaling to regulate the fidelity of ommatidial rotation in the Drosophila eye

Directed cellular movements are a universal feature of morphogenesis in multicellular organisms. Differential adhesion between the stationary and motile cells promotes these cellular movements to effect spatial patterning of cells. A prominent feature of Drosophila eye development is the 90° rotational movement of the multicellular ommatidial precursors within a matrix of stationary cells. We demonstrate that the cell adhesion molecules Echinoid (Ed) and Friend of Echinoid (Fred) act throughout ommatidial rotation to modulate the degree of ommatidial precursor movement. We propose that differential levels of Ed and Fred between stationary and rotating cells at the initiation of rotation create a permissive environment for cell movement, and that uniform levels in these two populations later contribute to stopping the movement. Based on genetic data, we propose that ed and fred impart a second, independent, `brake-like' contribution to this process via Egfr signaling. Ed and Fred are localized in largely distinct and dynamic patterns throughout rotation. However, ed and fred are required in only a subset of cells - photoreceptors R1, R7 and R6 - for normal rotation, cells that have only recently been linked to a role in planar cell polarity (PCP). This work also provides the first demonstration of a requirement for cone cells in the ommatidial rotation aspect of PCP. ed and fred also genetically interact with the PCP genes, but affect only the degree-of-rotation aspect of the PCP phenotype. Significantly, we demonstrate that at least one PCP protein, Stbm, is required in R7 to control the degree of ommatidial rotation.
The Quasi-Random Perspective on Matrix Spectral Analysis with Applications

Computing the eigenvectors and eigenvalues of a given Hermitian matrix is arguably one of the most well-studied computational problems. Yet despite its immense importance, and a vast array of heuristic techniques, there is no algorithm that can provably approximate the spectral decomposition of any Hermitian matrix in asymptotic bit-complexity o(n^3). Inspired by the quantum computing paradigm, we introduce a new perspective on this problem that draws from the theory of quasi-random, or low-discrepancy sequences - a theory which has been unconnected to linear-algebra problems thus far. We analyze the discrepancy of an n-dimensional sequence formed by taking the fractional part of integer multiples of the vector of eigenvalues of the input matrix. This analysis gives rise to a conceptually new algorithm to compute an approximate spectral decomposition of any n x n Hermitian matrix. This algorithm can be implemented by (randomized) circuits of bit-complexity at most O(n^{\omega+\nu}) for any \nu> 0. Because it is disjoint from previous algorithms, we hope it sheds new light on the complexity of approximate spectral decomposition, in terms of run-time, space complexity, and the number of random bits required.
Effectiveness of Iron Supplementation in a Young Child With Attention-Deficit/Hyperactivity Disorder

A 3-year-old child was referred to consultation for hyperactivity, attention deficit, impulsivity, and sleep problems. He met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for attention-deficit/hyperactivity disorder. At baseline, the Conners’ Parent Rating Scale and the Conners’ Teacher Rating Scale raw total scores were 30 and 32, respectively. The child had low a serum ferritin level (13 ng/mL). After 8 months of treatment with Tardyferon (ferrous sulfate, 80 mg/day), his serum ferritin increased to 102 ng/mL. Both parents and teachers reported considerable behavioral improvement. The Conners’ Parent and Teacher Rating Scale raw total scores decreased to 19 and 13, respectively. This is the first report of the effectiveness of iron supplementation in a young child with attention-deficit/hyperactivity disorder.
The Well-Being of Siblings of Individuals with Autism

Objective. The purpose of this review of the literature was to summarise studies regarding the psychosocial impact of growing up with a sibling with autism and to identify gaps in the related literature. Methods. Electronic databases were reviewed in order to critically appraise the 14 articles relevant to the topic. The search included a combination of the following key words: autism∗, quality of life, well-being, sibling∗, ASD, ASD sibling∗, family, adjust∗, psychological functioning. Results. The majority of studies involved mixed children and adolescent samples, leading to confounding results and an inability to draw accurate conclusions about these distinct life stages. Autism appears to contribute to unique environmental stressors for the typically developing sibling. When experienced in the context of additional demographic risk factors, these stressors can result in difficulties adjusting to the demands of a special-needs child. Despite some vulnerability to behavioural and emotional dysfunction in at-risk children, siblings have the potential to not only adjust but to thrive in the face of disability adversity. Conclusion. Growing up with a sibling with autism appears to manifest in both positive and negative outcomes for siblings, depending upon important demographical, family, and individual variables.
Evaluating performance of Chinese and Japanese mutual funds' listed in NASDAQ stock exchange

This study measures the performance of Chinese and Japanese mutual funds which are listed in Nasdaq Stock Exchange for period 2007 until 2010. This period is chosen because in 2006 both Japanese and Chinese mutual funds experienced bull market, but because of global economic crises happened since 2008, both of their performance has dropped. The objective of this research is to analyze whether the Chinese mutual funds have a better performance than Japanese funds during the economic crises or vice versa. The measurement tools that have been used are: Jensen Index, Treynor Index, Sharpe Index, and Snail Trail method. Jack Treynor, William Sharpe, and Michael Jensen identified the implications of using CAPM for evaluating the performance of investment advisers. These methods have received the most acceptance and the most widely used method in performance studies. This study discovers that the Chinese mutual funds seem to outperform the Japanese mutual funds even in the global economic crises. By using Snail Trail method, this study also found that the risk and the return are relative stable plotted in the 1st and 2nd quadrant for Chinese mutual funds.
Impact of Live Migration on Multi-tier Application Performance in Clouds

Live migration technologies can contribute to efficient resource management in a cloud datacenter; however, they will inevitably entail downtime for the virtual machine involved. Even if the downtime is relatively short, its effect can be serious for applications sensitive to response time degradations. Therefore, cloud datacenter providers should control live migration operations to minimize the impact on the performance of applications running on the cloud infrastructure. With this understanding, we studied the impact of live migration on the performance of 2-tier web applications in an experimental setup using XenServer and RUBBoS benchmark. We revealed that the behavior of the transmission control protocol (TCP) can be the primary factor responsible for response time degradation during live migration. On the basis of the experimental results, we constructed functions to estimate the performance impact of live migration on the applications. We also examined a case study to demonstrate how cloud computing datacenters can determine the best live migration strategy to minimize application performance degradation.
Characterization of Antibiotic Resistance Gene Abundance and Microbiota Composition in Feces of Organic and Conventional Pigs from Four EU Countries

One of the recent trends in animal production is the revival of interest in organic farming. The increased consumer interest in organic animal farming is mainly due to concerns about animal welfare and the use of antibiotics in conventional farming. On the other hand, providing animals with a more natural lifestyle implies their increased exposure to environmental sources of different microorganisms including pathogens. To address these concerns, we determined the abundance of antibiotic resistance and diversity within fecal microbiota in pigs kept under conventional and organic farming systems in Sweden, Denmark, France and Italy. The abundance of sul1, sul2, strA, tet(A), tet(B) and cat antibiotic resistance genes was determined in 468 samples by real-time PCR and the fecal microbiota diversity was characterized in 48 selected samples by pyrosequencing of V3/V4 regions of 16S rRNA. Contrary to our expectations, there were no extensive differences between the abundance of tested antibiotic resistance genes in microbiota originating from organic or conventionally housed pigs within individual countries. There were also no differences in the microbiota composition of organic and conventional pigs. The only significant difference was the difference in the abundance of antibiotic resistance genes in the samples from different countries. Fecal microbiota in the samples originating from southern European countries (Italy, France) exhibited significantly higher antibiotic resistance gene abundance than those from northern parts of Europe (Denmark, Sweden). Therefore, the geographical location of the herd influenced the antibiotic resistance in the fecal microbiota more than farm’s status as organic or conventional.
Correlations between Phlegm Syndrome of Chinese Medicine and Coronary Angiography: A Systematic Review and Meta-Analysis

Phlegm is one of the most common patterns of coronary artery disease (CAD) in Chinese medicine. Our research was aimed at investigating the association between phlegm syndrome of CAD and coronary angiography (CAG) by meta-analysis. According to inclusion criteria, a total of 30 studies involving 5,055 CAD patients were included. The meta-analysis showed that phlegm syndrome patients were prone to multivessel disease (28 studies, OR = 1.53, 95% CI, 1.24 to 1.88, P < 0.01) and higher Gensini score (2 studies, OR = 5.90, 95% CI, 1.86 to 9.94, P = 0.004), but not obviously relevant to severe stenosis (≥75%) of coronary arteries (13 studies, OR = 1.20, 95% CI, 0.63 to 2.27, P = 0.57). We concluded that the coronary arteries lesions of CAD patients with phlegm syndrome were more severe than those with nonphlegm syndromes. Phlegm syndrome should, therefore, be regarded as a dangerous pattern of CAD with worse prognosis.
Gastric residual volume and aspiration in critically ill patients receiving gastric feedings.

BACKGROUND The helpfulness of bedside assessment of gastric residual volume in the prediction of aspiration has been questioned, as has the volume that signals increased risk of aspiration. OBJECTIVE To describe the association between gastric residual volumes and aspiration of gastric contents. METHODS In a prospective study of 206 critically ill patients receiving gastric tube feedings for 3 consecutive days, gastric residual volumes were measured with 60-mL syringes every 4 hours. Measured volumes were categorized into 3 overlapping groups: at least 150 mL, at least 200 mL, and at least 250 mL. Patients were categorized as frequent aspirators if 40% or more of their tracheal secretions were positive for pepsin and as infrequent aspirators if less than 40% of their secretions were positive for pepsin. Gastric residual volumes were compared between the 2 aspiration groups. RESULTS Approximately 39% of the 206 patients had 1 or more gastric residual volumes of at least 150 mL, 27% had 1 or more volumes of at least 200 mL, and 17% had 1 or more volumes of at least 250 mL. Large-bore tubes identified most of the high volumes. Eighty-nine patients were frequent aspirators. Volumes less than 150 mL were common in both aspiration groups. However, the frequent aspirators had a significantly greater frequency of 2 or more volumes of at least 200 mL and 1 or more volumes of at least 250 mL. CONCLUSIONS No consistent relationship was found between aspiration and gastric residual volumes. Although aspiration occurs without high gastric residual volumes, it occurs significantly more often when volumes are high.
Cognitive and Neurophysiological Outcome of Cardiac Arrest Survivors Treated With Therapeutic Hypothermia

Background and Purpose— Cognitive deficits are common in survivors of cardiac arrest (CA). The aim of this study was to examine the effect of therapeutic hypothermia after CA on cognitive functioning and neurophysiological outcome. Methods— A cohort of 70 consecutive adult patients resuscitated from out-of-hospital ventricular fibrillation CA were randomly assigned to therapeutic hypothermia of 33°C for 24 hours accomplished by external cooling or normothermia. Neuropsychological examination was performed to 45 of the 47 conscious survivors of CA (27 in hypothermia and 18 in normothermia group) 3 months after the incident. Quantitative electroencephalography (Q-EEG) and auditory P300 event-related potentials were studied on 42 patients at the same time point. Results— There were no differences between the 2 treatment groups in demographic variables, depression, or delays related to the resuscitation. No differences were found in any of the cognitive functions between the 2 groups. 67% of patients in hypothermia and 44% patients in normothermia group were cognitively intact or had only very mild impairment. Severe cognitive deficits were found in 15% and 28% of patients, respectively. All Q-EEG parameters were better in the hypothermia-treated group, but the differences did not reach statistical significance. The amplitude of P300 potential was significantly higher in hypothermia-reated group. Conclusions— The use of therapeutic hypothermia was not associated with cognitive decline or neurophysiological deficits after out-of-hospital CA.
Inhibition of metastasis of lewis lung carcinoma by a synthetic peptide within growth factor‐like domain of urokinase in the experimental and spontaneous metastasis model

Four synthetic peptides (residues 20‐30 and 17‐34) within the growth factor‐like domain (GFD) of murine and human urokinase‐type plasminogen activator (uPA) were examined to determine whether they inhibit production of experimental and spontaneous lung metastasis by murine Lewis lung carcinoma (3LL) cells. In an in vivo experimental metastasis assay, which determines mainly the later steps of the metastatic migration process (extravasation from the bloodstream and then growth into pulmonary tumor), none of the peptides introduced by i.v. single co‐injection into syngeneic C57B1/6 mice inhibited pulmonary metastasis, when 3LL cells were pre‐incubated with the peptides followed by i.v. co‐injection of the peptide and cells. In addition, none of the peptides, when injected i.p. daily for 7 days after i.v. tumor cell inoculation, reduced the number of lung tumor colonies. In a second in vivo assay that measures metastasis from a primary tumor (spontaneous metastasis model), multiple i.p. injections of the mouse peptide 17‐34 for 7 days after s.c. tumor cell inoculation significantly inhibited metastatic lung tumor colonization in a dose‐dependent manner, whereas human peptide 17‐34 had no effect. Mouse and human peptide 20‐30 had no effect either. The inhibition of lung metastasis was not due to direct antitumor effects of mouse peptide 17‐34. Our results indicate that occupation of uPA receptors on 3LL cells by the enzymatically inactive mouse peptide 17‐34 or prevention of rebinding of uPA synthesized by tumor cells to their receptor specifically reduced tumor cell invasion and formation of metastasis and that uPA may regulate more efficiently the mechanism involved in the entry of tumor cells into vascular circulation than extravasation during the metastatic process.
Understanding Peer Influence in Children and Adolescents.

Part 1. Introduction. M.J. Prinstein, K.A. Dodge, Current Issues in Peer Influence Research. Part 2. Peer Influence Mechanisms. B.B. Brown, J.P. Bakken, S.W. Ameringer, S.D. Mahon, A Comprehensive Conceptualization of the Peer Influence Process in Adolescence. F.X. Gibbons, E.A. Pomery, M. Gerrard, Cognitive Social Influence: Moderation, Mediation, Modification, and.the Media. T.J. Dishion, T.F. Piehler, M.W. Myers, Dynamics and Ecology of Adolescent Peer Influence. H. Blanton, M. Burkley, Deviance Regulation Theory: Applications to Adolescent Social Influence. Part 3. Altering Peer Influence Effects: Moderators and Interventions. W.M. Bukowski, A.M. Velasquez, M. Brendgen, Variation in Patterns of Peer Influence: Considerations of Self and Other. J.P. Allen, J. Antonishak, Adolescent Peer Influences: Beyond the Dark Side. D.A. Prentice, Mobilizing and Weakening Peer Influence as Mechanisms for Changing Behavior: Implications for Alcohol Intervention Programs. J. Berger, Identity Signaling, Social Influence, and Social Contagion. Part 4. Underexplored Contexts for Potential Peer Influence Effects. W. Furman, V.A. Simon, Homophily in Adolescent Romantic Relationships. J. Juvonen, A. Galvan, Peer Influence in Involuntary Social Groups: Lessons from Research on Bullying.