Miracle-dz/UniFAR-FTUs huggingface dataset:
On entrepreneurship, in a different voice? Finnish entrepreneurship education and pupils’ critical narratives of the entrepreneur

This study set out to explore the narratives of entrepreneurship that 15–16-year-old pupils in their last grade of comprehensive school produced in the Finnish annual writing competition Good Enterprise! We focused on narratives that can be categorized as tragedies, satires, comedies, and crime stories (N = 219). In these stories, the pupils challenge the political ideal of the risk-taking entrepreneur by arguing for sustainable development and social justice as bases for entrepreneurship. On the one hand, the critical representations of entrepreneurs arise from the Protestant work ethic, and thus the values constructed in these stories are close to stories that can be characterized as romances of the modest entrepreneur where the motive for entrepreneurship was not the accumulation of material wealth. On the other hand, these critical stories represent “entrepreneur and consumer pathologies,” and hence make a mockery of the core neoliberal values of autonomy, competition, and choice.
Hybrid Cyberphysical System Verification with Simplex Using Discrete Abstractions

Providing integrity, efficiency, and performance guarantees is a key challenge in the development of next-generation cyberphysical systems. Rather than mandating complete system verification, the Simplex Architecture provides robust designs by incorporating a supervisory controller that takes corrective action only when the system is in danger of violating a desired invariant property such as safety. The central issue in applying this approach is designing the switching logic for the supervisory controller such that it guarantees safety and at the same time is not overly conservative.Previous research in the area relied on finding Lyapunov functions for the underlying continuous dynamical system. In contrast, in this paper, we present an automatic method for solving this design problem through discrete abstractions of the underlying hybrid system and model checking. We present a case study where, in collaboration with John Deere, we use the developed approach to create the Simplex decision module for an off-road vehicle, which is formally verified as both correct and timely.
A Computational Approach to Conceptual Design

Design research has generated many computational tools to aid the designer over the years. Most of these tools are focused on either the preliminary steps of customer need gathering or the concluding steps of embodiment or detail design. The conceptual design phase has seen fewer computational tools even though well known methods are available such as brainstorming, intrinsic and extrinsic searches and morphological analysis. In this paper a generalized computational conceptual design tool is presented to aid designers at the conceptual design stage. It relies on storing and reusing existing design knowledge to create new concept variants. Concept variants are computed using matrix manipulations, essentially creating a mathematical morphological matrix. The concept generator produces quick concepts that can be used for concept selection or as a basis for generating additional concept variants through non-computational, creative techniques
The Val34Leu genetic variation in the A Subunit of Coagulation Factor XIII in recurrent spontaneous abortion

The present study was carried out to assess the frequencies of factor XIII (FXIII) Val34Leu genetic variation in the patients with recurrent spontaneous abortion and healthy fertile women of Azeri Turkish origin. A total of 54 patients with recurrent spontaneous abortion and 46 healthy fertile women as controls were studied for the FXIII Val34Leu genetic variation by a RFLP-PCR method. Statistical analysis showed that patients (χ2 = 2.4, p value = 0.292) and controls (χ2 = 1.035, p value = 0.596) were in agreement with Hardy-Weinberg equilibrium. The Leu allele frequency was 0.18 and 0.13 in patients and controls, respectively. FXIII Leu34Leu (homozygous for 34Leu) genotype was not found in patients and controls. FXIII Val/Leu and Val/Val genotype frequencies were 19 (35.19%) and 31 (64.81%) in patients and 12 (26.09%) and 34 (73.91%) in controls, respectively. FXIII 34Leu allele and Val34Leu genotypes were more common in the case group containing individuals with unexplained RSA but the differences of FXIII Val34Leu (G/T genotype) (odds ratio = 0.65 (0.25 < OR < 1.67) corresponding to 95% CI, χ2 = 0.96, p value = 0.32) and FXIII 34Leu (T allele) (odds ratio = 0.70 (0.30 < OR < 1.64) corresponding to 95% CI, χ2 = 0.78, p value = 0.37) was not statistically significant. These results suggest that factor XIII Val34Leu genetic variation is not associated with recurrent spontaneous abortion.
DNA Vaccines Encoding Antigen Targeted to MHC Class II Induce Influenza-Specific CD8+ T Cell Responses, Enabling Faster Resolution of Influenza Disease

Current influenza vaccines are effective but imperfect, failing to cover against emerging strains of virus and requiring seasonal administration to protect against new strains. A key step to improving influenza vaccines is to improve our understanding of vaccine-induced protection. While it is clear that antibodies play a protective role, vaccine-induced CD8+ T cells can improve protection. To further explore the role of CD8+ T cells, we used a DNA vaccine that encodes antigen dimerized to an immune cell targeting module. Immunizing CB6F1 mice with the DNA vaccine in a heterologous prime-boost regime with the seasonal protein vaccine improved the resolution of influenza disease compared with protein alone. This improved disease resolution was dependent on CD8+ T cells. However, DNA vaccine regimes that induced CD8+ T cells alone were not protective and did not boost the protection provided by protein. The MHC-targeting module used was an anti-I-Ed single chain antibody specific to the BALB/c strain of mice. To test the role of MHC targeting, we compared the response between BALB/c, C57BL/6 mice, and an F1 cross of the two strains (CB6F1). BALB/c mice were protected, C57BL/6 were not, and the F1 had an intermediate phenotype; showing that the targeting of antigen is important in the response. Based on these findings, and in agreement with other studies using different vaccines, we conclude that, in addition to antibody, inducing a protective CD8 response is important in future influenza vaccines.
The role of wealth in the experience of quality of life of the semi-affluent investor.

In an attempt to assist semi-affluent investors’ best use their wealth to improve their lives, this study explores the role of wealth in the experience of quality of life. Seven clients of a financial advisory firm based in the U.S.A, were interviewed using the repertory grid technique. Through an interpretive analysis wealth was found to influence the experience of quality of life in the way that it was used to satisfy individual material and security needs; shape growth and relatedness needs and influence how respondents establish, maintain and verify their identity.
Combining search-based and constraint-based testing

Many modern automated test generators are based on either meta-heuristic search techniques or use constraint solvers. Both approaches have their advantages, but they also have specific drawbacks: Search-based methods get stuck in local optima and degrade when the search landscape offers no guidance; constraint-based approaches, on the other hand, can only handle certain domains efficiently. In this paper we describe a method that integrates both techniques and delivers the best of both worlds. On a high-level view, our method uses a genetic algorithm to generate tests, but the twist is that during evolution a constraint solver is used to ensure that mutated offspring efficiently explores different control flow. Experiments on 20 case study examples show that on average the combination improves branch coverage by 28% over search-based techniques and by 13% over constraint-based techniques.
Human herpesvirus 6 DNA in cerebrospinal fluid specimens from allogeneic bone marrow transplant patients: does it have clinical significance?

Cerebrospinal fluid (CSF) specimens from 22 allogeneic bone marrow transplant patients with central nervous system (CNS) symptoms (cases) and 107 patients who were immunocompromised but did not have CNS symptoms (controls) were assayed for human herpesvirus 6 (HHV-6) DNA. HHV-6 DNA was detected in CSF specimens from five (23%) of 22 cases and in CSF specimens from one (0.9%) of 107 controls (P < .001, Fisher's exact test). In addition, none of the five cases with HHV-6 DNA detected in CSF samples had any other identified cause of their CNS symptoms, and none of the other 11 cases with known causes for their CNS diseases had HHV-6 DNA detected in CSF samples (P = .03, Fisher's exact test). In three cases, HHV-6 variant B was identified, and the HHV-6 variant could not be defined in the other two cases. Prophylaxis with acyclovir did not prevent the occurrence of HHV-6-associated CNS disease after allogeneic bone marrow transplantation. Four cases' conditions were improved or they were cured after treatment with either ganciclovir or foscarnet, and one case died of CNS disease despite foscarnet treatment.
Political Talk Radio: The Limbaugh Effect on Primary Voters

Recent studies suggest that what the political talk radio hosts say on the air can shape the political orientations of their audiences. Drawing on data from a panel survey conducted in 1996, I examined the "Limbaugh effect" during the GOP presidential nomination campaign. My findings cast doubt on popular assumptions about the power of Limbaugh's words. Despite weeks of listening to Limbaugh criticize Pat Buchanan, members of the audience were no more likely to harbor negative feelings toward the candidate than were nonlisteners.
Reading Instruction and Cognitive Development

cognitive development. Though the expression "reading as a thinking process" is almost a clich6, the actual accomplishments in making reading a challenge to higher levels of thought seem somewhat disappointing. In a widely quoted speech delivered a decade ago, Francis Chase declared that civilization was threatened by two kinds of illiteracy-simple illiteracy, or the inability to adequately reconstruct a writer's message, and higher illiteracy, or the inability of the reader to relate the ideas gained through reading to himself and the world in which he lives (1). The higher illiterate, Dr. Chase contended, was facile in the ability to absorb and recall what a writer puts on paper but unable to go the extra mile and ". carry on a translation between the world of
Gambling over the life course and treatment-seeking

The purpose of this study is to investigate change in gambling behaviours over the life course, and, correspondingly, the treatment-seeking behaviours of 86 people who met the criteria for at-risk (participants endorsing two to four items on the South Oaks Gambling Screen [SOGS]) and problem gamblers (participants endorsing five or more items on the SOGS) over the last five years. Data were obtained from informants during semi-structured interviews using Structured Clinical Interview for DSM-IV axis I and axis II disorders (SCID I and II), SOGS and treatment-seeking interviews. The results showed three groups of gambling behaviours over the life course. A first group started gambling early on and continued participating in recreational gambling until its participants were between 40 and 50 years of age, during which time they became problem gamblers. A second group transitioned from recreational gambling to problem gambling over a short period of time; its participants were aged between 40 and 50. Lastly, a third group which was exposed to gambling later on in life, mostly after retirement, developed gambling problems quickly. Psychopathology was prevalent in all groups, given that 98% suffered from a mental health problem during their life, and 62% within the last six months. Participants who made use of the services available mostly turned to medical and specialized mental services for brief periods, usually when in crisis. In terms of problem gambling, the results argue in favour of maintaining dedication toward treatment, especially in the presence of co-morbidity.
Comparing gaze-based and manual interaction in a fast-paced gaming task in Virtual Reality

The idea of using gaze as an interaction modality has been put forward by the famous work of Bolt in 1981. In virtual reality (VR), gaze has been used for several means since then: view-dependent optimization of rendering, intelligent information visualization, reference communication in distributed telecommunication settings and object selection. Our own research aims at improving gaze-based interaction methods in general. In this paper, gaze-based interaction is examined in a fast-paced selection task to identify current usability problems of gaze-based interaction and to develop best practices. To this end, an immersive Asteroids-like shooter called Eyesteroids was developed to support a study comparing manual and gaze-based interaction methods. Criteria for the evaluation were interaction performance and user immersion. The results indicate that while both modalities (hand and gaze) work well for the task, manual interaction is easier to use and often more accurate than the implemented gaze-based methods. The reasons are discussed and the best practices as well as options for further improvements of gaze-based interaction methods are presented.
iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing cancer driver genes in personal genomes

All cancers arise as a result of the acquisition of somatic mutations that drive the disease progression. A number of computational tools have been developed to identify driver genes for a specific cancer from a group of cancer samples. However, it remains a challenge to identify driver mutations/genes for an individual patient and design drug therapies. We developed iCAGES, a novel statistical framework to rapidly analyze patient-specific cancer genomic data, prioritize personalized cancer driver events and predict personalized therapies. iCAGES includes three consecutive layers: the first layer integrates contributions from coding, non-coding and structural variations to infer driver variants. For coding mutations, we developed a radial support vector machine using manually curated mutations to predict their driver potential. The second layer identifies driver genes, by using information from the first layer and integrating prior biological knowledge on gene-gene and gene-phenotype networks. The third layer prioritizes personalized drug treatment, by classifying potential driver genes into different categories and querying drug-gene databases. Compared to currently available tools, iCAGES achieves better performance by correctly classifying point coding driver mutations (AUC=0.97, 95% CI: 0.97-0.97, significantly better than the second best tool with P=0.01) and genes (AUC=0.93, 95% CI: 0.93-0.94, significantly better than MutSigCV with P<1×10−15). We also illustrated two examples where iCAGES correctly nominated two targeted drugs for two advanced cancer patients with exceptional response, based on their somatic mutation profiles. iCAGES leverages personal genomic information and prior biological knowledge, effectively identifies cancer driver genes and predicts treatment strategies. iCAGES is available at http://icages.usc. edu.
Terrain modeling: a constrained fractal model

We present an algorithm mainly designed to reconstruct Digital Elevation Maps (DEM). Our approach relays on a fast and highly controllable fractal-based algorithm, we are able to create DEMs according to given constraints. Thus, these constraints can be given as scattered dataset of elevations obtained by satellite, our method supersamples this data and creates the according smooth terrain surface. Moreover, as a painter can make a sketch of his model, the final user can give or edit the main characteristics, local details and morphology, of his wanted DEM instantaneously obtaining the resulting terrain surface. Note that there is no limitation on the number of local constraints (that could vary from 0 to the number of points of the final DEM). Thus, the method we propose gives the ability to modify the global aspect (the surface behavior) as well as to constrain any local detail of the final terrain model. This paper presents the algorithm and reconstruction examples. Using a Root Mean Square Error computation between an original model and its downsampled-then-reconstructed version, the results confirm the method good behavior and show its efficiency. Other various terrain models and alternative applications are presented.
The impact of left prefrontal repetitive transcranial magnetic stimulation on depression in Parkinson's disease: A randomized, double‐blind, placebo‐controlled study

Based on several open‐label and case studies, repetitive transcranial magnetic stimulation (rTMS) seems to have an antidepressive effect on patients with Parkinson's disease (PD). However, this hypothesis requires further confirmation. We conducted a randomized, double‐blind placebo‐controlled study to evaluate the effect of rTMS over the left dorsolateral prefrontal cortex (DLPFC) on depression and various motor and nonmotor features of PD. Twenty‐two PD patients with mild or moderate depressive episodes were assigned into two groups, one receiving real‐rTMS (90% of resting motor threshold, 5 Hz, 600 pulses‐a‐day for 10 days) over the left DLPFC, and another group receiving sham‐rTMS. An investigator blinded to the treatment performed three video‐taped examinations on each patient: before stimulation (baseline), 1 day (short term), and 30 days after treatment session ended (long‐term effect). Mini‐Mental State Examination, Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn‐Yahr, Epworth Sleepiness, Visual Analog and Montgomery‐Asberg Depression Rating Scales (MADRS), Beck Depression Inventory (BDI), and Trail making and Stroop tests were applied. In the actively treated group, not only depression rating scales showed significant improvement 30 days after treatment ended (BDI by 44.4% and MADRS by 26.1%), but also the accuracy of Stroop test (by 16%). We could also demonstrate an insignificant improvement in UPDRS‐III by 7.5 points (31.9%, P = 0.06). In the sham‐treated group none of the examined tests and scales improved significantly after sham stimulation. Our study demonstrated the beneficial effect of the left DLPFC rTMS on depression in PD lasting at least 30 days after treatment. However, this result should be confirmed in patients with severe depression by further clinical trials. © 2010 Movement Disorder Society
Issues relating to the use of forgiveness in counselling and psychotherapy

This paper explores forgiveness, which is a key component of spiritual pastoral care. Encouraging forgiveness is also one of the spiritual interventions most frequently used by psychotherapists. However, although forgiveness has been explored as an element in psychotherapy, the models generated have had little impact on research and practice. Recent research into forgiveness in therapy is considered, including several models put forward for its use. Some of the implications of the use of forgiveness in therapeutic practice are examined and guidelines for the use of forgiveness in psychotherapy are put forward based on the work of the Forgiveness Project at the University of Manchester.
Visual Impairment: The Use of Visual Profiles in Evaluations of Icon Use in Computer-Based Tasks

This research investigates an empirical link between characteristics of impaired vision and user performance on computer-based systems. The underlying premise of this research is twofold: specific aspects of visual dysfunction can be linked to the task performance demonstrated by computer users with impaired vision, and graphical user interfaces can be modified to evoke enhanced performance from low-vision users. Iconic selection time and accuracy within a graphical user interface were evaluated, comparing performance of low-vision users with performance of fully sighted users, and linking task performance to specific profiles of visual impairment. Results indicate that visual acuity, contrast sensitivity, visual field, and color perception were significant predictors of task performance. In addition, icon size, set size, and background color significantly influenced performance. This research confirmed the validity of both underlying premises and serves as a launching point for future research concerned with developing features that will assist users with a variety of visual deficits.
Dopamine Supports Coupling of Attention-Related Networks

Attentional processing has been associated with the dorsal attention, default mode, and frontoparietal control networks. The dorsal attention network is involved in externally focused attention whereas the default mode network is involved in internally directed attention. The frontoparietal control network has been proposed to mediate the transition between external and internal attention by coupling its activity to either the dorsal attention network or the default mode network, depending on the attentional demand. Dopamine is hypothesized to modulate attention and has been linked to the integrity of these three attention-related networks. We used PET with 6-[18F]fluoro-L-m-tyrosine to quantify dopamine synthesis capacity in vivo and fMRI to acquire stimulus-independent brain activity in cognitively healthy human subjects. We found that in the resting state where internal cognition dominates, dopamine enhances the coupling between the frontoparietal control network and the default mode network while reducing the coupling between the frontoparietal control network and the dorsal attention network. These results add a neurochemical perspective to the role of network interaction in modulating attention.
Kinetic interactions of tazobactam with beta-lactamases from all major structural classes

Tazobactam was shown to be a potent inhibitor of group 1, 2a, 2b, and 2b' beta-lactamases. Extended kinetic studies with class A and C serine beta-lactamases showed that the PC1, TEM-2, and P99 enzymes all were reversibly inhibited prior to inactivation of the enzymes. The CcrA metallo-beta-lactamase was less well inhibited, with a 50% inhibitory concentration at least 3 orders of magnitude less favorable than those for most serine beta-lactamases. The numbers of hydrolytic turnovers of tazobactam before inactivation were 2 for PC1, 125 for TEM-2, 50 for P99, and 4,000 for the CcrA enzyme. In spectral studies, transient intermediates were formed after reaction of tazobactam with the PC1, TEM-2, and CcrA beta-lactamases, corresponding to enzyme-associated intermediates responsible for hydrolysis of tazobactam. Chromophores absorbing at 270 nm (CcrA) and 288 nm (TEM-2 and PC1) were observed for these reaction intermediates. The P99 cephalosporinase formed a stable complex with a UV maximum at 295 nm. Incubation of tazobactam with all of the enzymes resulted in accumulation of a tazobactam reaction product with a short-wavelength absorbance. This product has characteristics similar to those of the major eucaryotic metabolite of tazobactam. Possible reaction mechanisms are presented to explain the findings. In conclusion, both serine-based and metallo-beta-lactamases were irreversibly inactivated by tazobactam following an initial transient inhibition phase.