Miracle-dz/UniFAR-FTUs huggingface dataset:
Bone Morphogenetic Protein-1/Tolloid-like Proteinases Process Dentin Matrix Protein-1*

Bone morphogenetic protein-1 (BMP-1)/Tolloid-like metalloproteinases play key roles in formation of mammalian extracellular matrix (ECM), through the biosynthetic conversion of precursor proteins into their mature functional forms. These proteinases probably play a further role in formation of bone through activation of transforming growth factor β-like BMPs. Dentin matrix protein-1 (DMP1), deposited into the ECM during assembly and involved in initiating mineralization of bones and teeth, is thought to undergo proteolysis in vivo to generate functional cleavage fragments found in extracts of mineralized tissues. Here, we have generated recombinant DMP1 and demonstrate that it is cleaved, to varying extents, by all four mammalian BMP-1/Tolloid-like proteinases, to generate fragments similar in size to those previously isolated from bone. Consistent with possible roles for the BMP-1/Tolloid-like proteinases in the physiological processing of DMP1, NH2-terminal sequences of products generated by BMP-1 cleavage of DMP1 match those predicted from processing at the predicted DMP1 site that shows greatest cross-species conservation of sequences. Moreover, fibroblasts derived from mouse embryos homozygous null for genes encoding three of the four mammalian BMP-1/Tolloid-like proteinases appear to be deficient in processing of DMP1. Thus, a further role for BMP-1-Tolloid-like proteinases in formation of mineralized tissues is indicated, via proteolytic processing of DMP1.
Which influence tactics lead to sales performance? It is a matter of style

The application of influence is a key behaviour set at the heart of the sales role. But we know little about how or whether influence tactics affect salespeople's actual job performance. We extend existing research on salespeople's use of influence by: (1) showing that influence tactics can be used to predict objective sales performance (and delineating which tactics are most predictive); (2) demonstrating that the effect of tactics on performance varies across salespeople, and these patterns of influence effectiveness allow us to identify different influence ‘styles’ and (3) revealing that the influence styles our data uncover are not consistent with existing theoretical classifications of influence tactics. The article concludes with a discussion of theoretical and managerial implications, and directions for future work.
Reconstructing patient-specific cardiac models from contours via Delaunay triangulation and graph-cuts

This study proposes a novel method to reconstruct the left cardiac structure from contours. Given the contours representing left ventricle (LV), left atrium (LA), and aorta (AO), re-orientation, contour matching, extrapolation, and interpolation are performed sequentially. The processed data are then reconstructed via a variational method. The weighted minimal surface model is revised to handle the multi-phase cases, which happens at the LV-LA-AO junction. A Delaunay-based tetrahedral mesh is generated to discretize the domain while the max-flow/min-cut algorithm is utilized as the minimization tool. The reconstructed model including LV, LA, and AO structure is extracted from the mesh and post-processed further. Numerical examples show the robustness and effectiveness of the proposed method.
VarSifter: Visualizing and analyzing exome-scale sequence variation data on a desktop computer

UNLABELLED VarSifter is a graphical software tool for desktop computers that allows investigators of varying computational skills to easily and quickly sort, filter, and sift through sequence variation data. A variety of filters and a custom query framework allow filtering based on any combination of sample and annotation information. By simplifying visualization and analyses of exome-scale sequence variation data, this program will help bring the power and promise of massively-parallel DNA sequencing to a broader group of researchers. AVAILABILITY AND IMPLEMENTATION VarSifter is written in Java, and is freely available in source and binary versions, along with a User Guide, at http://research.nhgri. nih.gov/software/VarSifter/.
Multichannel Signal Enhancement Algorithms for Assisted Listening Devices: Exploiting spatial diversity using multiple microphones

In everyday environments, we are frequently immersed by unwanted acoustic noise and interference while we want to listen to acoustic signals, most often speech. Technology for assisted listening is then desired to increase the efficiency of speech communication, reduce listener fatigue, or just allow for enjoying undisturbed sounds (e.g., music). For people with normal hearing, assisted listening devices (ALDs) mainly aim to achieve hearing protection or increase listening comfort; however, for hearing-impaired individuals, as the most prominent user group so far, further progress of assisted listening technology is crucial for better inclusion into our world of pervasive acoustic communication.
Vigilance, active coping, and cardiovascular reactivity during social interaction in young men.

This study of 72 undergraduate men examined the effects of two determinants of cardiovascular response-active coping and vigilance-on blood pressure and heart rate responses to social stressors. Observation of a future debate partner (i.e., vigilance) evoked larger increases in blood pressure than did observation of a less relevant person, apparently through the combination of increases in cardiac output and vascular resistance. Preparation and enactment of efforts to exert social influence (i.e., active coping) evoked heightened blood pressure and heart rate responses through increased cardiac contractility and output. Thus, both vigilance and active coping in social contexts increased cardiovascular reactivity, but apparently through different psychophysiological processes.
An Investigation into Target Setting and Academic Tutoring to Promote Student Learning

There has been a move in schools towards the use of pupil performance data to set targets. It is believed that effective target setting can motivate pupils and staff to strive to reach, or beat, target grades. Alongside this has been a move to promote more effective dialogue about learning between teachers and pupils through the use of academic tutoring. There is a belief that in combination a system of target setting and academic tutoring might lead to more effective learning, increased achievement and therefore school improvement. This investigation into one system of target setting and academic tutoring suggests that although these systems may promote increased achievement in terms of examination performance, they do not necessarily help students to learn more effectively. For this schools must attempt to develop in ways that make learning an explicit subject of discussion, and help students learn about learning. Therefore, it is on the development of student meta–learning that such school improvement efforts should focus.
Language typology, task complexity and the development of L2 lexicalization patterns for describing motion events

The present paper focuses on the acquisition of L2 constructions for the expression of motion from a typological (Cadierno, 2008; Talmy, 1985, 1991, 2000) and a psycholinguistic perspective with implications for pedagogy (Robinson, 2003a, 2007; Robinson & Gilabert, 2007a, 2007b). Specifically, we report the results of a cross-linguistic study which examined the extent to which the manipulation of pedagogic tasks in terms of cognitive complexity can facilitate the development of target-like lexicalization patterns and appropriate L2 ways of thinking-for-speaking for the expression of motion by adult L2 learners with typologically similar and typologically different L1s and L2s, i.e., Danish vs. Japanese L1 learners of English. The results of the study show that level of L2 proficiency, assessed using a cloze test, predicts more target-like reference to L2 motion across both L1 groups. Typological similarity between the L1 (Danish) and L2 (English) results in greater use of motion constructions incorporating mention of ground of motion compared to their use by Japanese L1 speakers. More cognitively complex tasks lead to production of more target-like lexicalization patterns, but also only for speakers of the typologically similar L1, Danish.
Social Identity Theory and the Crisis of Confidence in Social Psychology: A Commentary, and Some Research on Uncertainty Reduction

The role played by social identity theory in responding to the crisis of confidence in social psychology is described. It is a theory that addresses group processes and intergroup relations by separating and articulating different levels of explanation. Social categorization depersonalizes perception, cognition, affect and conduct in terms of relevant ingroup or outgroup prototypes, and social categorization of self, in conjunction with beliefs about the nature of intergroup relations, is responsible for specific manifestations of group behavior. Social identity theory continues to develop. In this article we focus on the motivational role of subjective uncertainty reduction in social identification - a model is outlined (Hogg & Mullin, 1999), and data from a 2 × 2 minimal group experiment in which categorization and uncertainty were orthogonally manipulated (N = 151) are presented. As predicted, categorization produced discrimination, elevated identification, and reduced uncertainty, but only, or more markedly, under conditions where subjective uncertainty was relatively high.
Characterization of Wolbachia Host Cell Range via the In Vitro Establishment of Infections

ABSTRACT Maternally transmitted bacteria of the genus Wolbachia are obligate, intracellular symbionts that are frequently found in insects and cause a diverse array of reproductive manipulations, including cytoplasmic incompatibility, male killing, parthenogenesis, and feminization. Despite the existence of a broad range of scientific interest, many aspects of Wolbachia research have been limited to laboratories with insect-rearing facilities. The inability to culture these bacteria outside of the invertebrate host has also led to the existing bias of Wolbachia research toward infections that occur in host insects that are easily reared. Here, we demonstrate that Wolbachia infections can be simply established, stably maintained, and cryogenically stored in vitro using standard tissue culture techniques. We have examined Wolbachia host range by introducing different Wolbachia types into a single tissue culture. The results show that an Aedes albopictus (Diptera: Culicidae) cell line can support five different Wolbachia infection types derived from Drosophila simulans (Diptera: Drosophilidae), Culex pipiens (Culicidae), and Cadra cautella (Lepidoptera: Phycitidae). These bacterial types include infection types that have been assigned to two of the major Wolbachia clades. As an additional examination of Wolbachia host cell range, we demonstrated that a Wolbachia strain from D. simulans could be established in host insect cell lines derived from A. albopictus, Spodoptera frugiperda (Lepidoptera: Noctuidae), and Drosophila melanogaster. These results will facilitate the development of a Wolbachia stock center, permitting novel approaches for the study of Wolbachia infections and encouraging Wolbachia research in additional laboratories.
A Fast Convergence DOA Estimation Algorithm

A novel pilot-assistant DOA estimation algorithm is presented based on the Butler matrix. The orthogonal channel code is used to avoid the correlation between the desired signal and the interference. The algorithm is combined of a rough estimation stage and an accurate estimation stage which are mostly fulfilled by hardware. It approaches the DOA of the desired signal iteratively through the variable phase shifter. And the accuracy of the algorithm can be decided by users. The merits of its low-complexity and quick convergence make it suitable to be used in ad-hoc network terminals. Simulation results verified the algorithm.
Fisheyes in the field: using method triangulation to study the adoption and use of a source code visualization

Information visualizations have been shown useful in numerous laboratory studies, but their adoption and use in real-life tasks are curiously under-researched. We present a field study of ten programmers who work with an editor extended with a fisheye view of source code. The study triangulates multiple methods (experience sampling, logging, thinking aloud, and interviews) to describe how the visualization is adopted and used. At the concrete level, our results suggest that the visualization was used as frequently as other tools in the programming environment. We also propose extensions to the interface and discuss features that were not used in practice. At the methodological level, the study identifies contributions distinct to individual methods and to their combination, and discusses the relative benefits of laboratory studies and field studies for the evaluation of information visualizations.
SSIG and IRISA at Multimodal Person Discovery

This paper describes our approach and results in the multi-modal person discovery in broadcast TV task at MediaEval 2015. We investigate two distinct aspects of multimodal person discovery. One refers to face clusters, which are considered to propagate names associated to faces in one shot to other faces that probably belong to the same person. The face clustering approach consists in calculating face similarities using partial least squares (PLS) and a simple hierarchical approach. The other aspect refers to tag propagation in a graph-based approach where nodes are speaking faces and edges link similar faces/speakers. The advantage of the graph-based tag propagation is to not rely on face/speaker clustering, which we believe can be errorprone.
NEED4Tweet: A Twitterbot for Tweets Named Entity Extraction and Disambiguation

In this demo paper, we present NEED4Tweet, a Twitterbot for named entity extraction (NEE) and disambiguation (NED) for Tweets. The straightforward application of state-of-the-art extraction and disambiguation approaches on informal text widely used in Tweets, typically results in significantly degraded performance due to the lack of formal structure; the lack of sufficient context required; and the seldom entities involved. In this paper, we introduce a novel framework that copes with the introduced challenges. We rely on contextual and semantic features more than syntactic features which are less informative. We believe that disambiguation can help to improve the extraction process. This mimics the way humans understand language.
Centenary Paper: Plan and constitution – Aristotle's Hippodamus: towards an 'ostensive' definition of spatial planning

This paper is part of ongoing research into the relationship between planning and citizenship. It focuses on two passages from Aristotle's Politics. The first indicates that Hippodamus was a political philosopher and a planner and suggests that he cannot be considered the 'inventor' of the orthogonal grid, but rather may be regarded as the first to theorise about the division of population and land within the city and to establish the connection between plan and constitution, that is, between the plan and various forms of citizenship. In the second passage two models of spatial plan are set against each other as expressions of innovation and tradition and Aristotle discusses the difference between functional and aesthetic aims and prudence, i.e. technical rationality and political reason. On this basis the paper introduces the spatial inclusion/exclusion pairing as 'a concept of planning' and discusses some notes on rules, customs and tastes which may be helpful in designing a theory of a spatial plan.
Dynamic Antenna Management for Uplink Energy Efficiency on 802.11n Mobile Devices

An increasing number of mobile devices are being equipped with 802.11n interfaces to support bandwidth-intensive applications; however, the improved bandwidth increases power consumption. To address the issue, researchers are focusing on antenna management. In this paper, we present a dynamic antenna management (DAM) scheme to improve the uplink energy efficiency on mobile devices whose packet workloads may vary significantly and frequently. First, we model antenna management as an optimization problem, with the objective of minimizing the energy required to transmit a sequence of variable-length packets with random arrival times. Then, we propose an optimal offline algorithm to solve the problem, as well as a competitive online algorithm that has a provable performance guarantee and allows compatible implementations on 802.11n mobile devices. To evaluate our scheme, we conducted extensive simulations based on real mobile user traces and application transmission patterns. Nearly all commercial 802.11n mobile devices support the power save mode (PSM). Our results demonstrate that DAM can improve the energy efficiency of PSM significantly at a cost of slight throughput degradation.
Bauhinia variegata Leaf Extracts Exhibit Considerable Antibacterial, Antioxidant, and Anticancer Activities

The present study reports the phytochemical profiling, antimicrobial, antioxidant, and anticancer activities of Bauhinia variegata leaf extracts. The reducing sugar, anthraquinone, and saponins were observed in polar extracts, while terpenoids and alkaloids were present in nonpolar and ethanol extracts. Total flavonoid contents in various extracts were found in the range of 11–222.67 mg QE/g. In disc diffusion assays, petroleum ether and chloroform fractions exhibited considerable inhibition against Klebsiella pneumoniae. Several other extracts also showed antibacterial activity against pathogenic strains of E. coli, Proteus spp. and Pseudomonas spp. Minimum bactericidal concentration (MBC) values of potential extracts were found between 3.5 and 28.40 mg/mL. The lowest MBC (3.5 mg/mL) was recorded for ethanol extract against Pseudomonas spp. The antioxidant activity of the extracts was compared with standard antioxidants. Dose dependent response was observed in reducing power of extracts. Polar extracts demonstrated appreciable metal ion chelating activity at lower concentrations (10–40 μg/mL). Many extracts showed significant antioxidant response in beta carotene bleaching assay. AQ fraction of B. variegata showed pronounced cytotoxic effect against DU-145, HOP-62, IGR-OV-1, MCF-7, and THP-1 human cancer cell lines with 90–99% cell growth inhibitory activity. Ethyl acetate fraction also produced considerable cytotoxicity against MCF-7 and THP-1 cell lines. The study demonstrates notable antibacterial, antioxidant, and anticancer activities in B. variegata leaf extracts.
The contrasting social logics of sociality and survival : Cultures of classed be/longing in late modernity

Late modernity has been characterized as a space, place and ‘series of flows’, marking conditions of complexity, contradiction and diversity as the global economics of capital restructuring reach down into the local/e to radically disorganize prior social forms of collective and political identity and allegiance (Giddens, 1998). Individualization implies a de-coupling of self from the weight of group, community and tradition, thus more local, idiosyncratic and syncretic trajectories are now said to structure ‘biographies of choice’. My starting points for reflecting on this are Bourdieu’s conceptualization of the ‘social logics of the individual’ conceived as a thoroughly social subject. I use this idea to frame how two contrasting locales shape the subject within their respective interpersonal relations. Gender and class are central terms of the following discussion examining the newly improvized identities of the digitally enhanced and networked middle class, alongside the survival identities impelled by those ‘muddling through’ within disconnected locales.
ć Professor Columbia University Development of a Packed Bed Bioreactor for Cartilage Tissue

Efficient transport of regulatory molecules is one of the main requirements for directing the growth and differentiation of bone marrow stromal cells (BMSC). We have designed and utilized a packed bed bioreactor system for cultivation of murine BMSC immobilized in alginate microbeads produced by electrostatic droplet generation. Continuous medium perfusion at velocities that are physiological for cartilage and bone (~ 100 μm/s) provided convective mass transport through the packed bed while the small bead diameter (~ 500 μm) ensured short diffusion distances to the immobilized cells. Over 5 weeks of cultivation, the cells remained viable at a constant density whereas the alginate microbeads retained size and spherical shape. Cell density used in this study ( 5 x 10 cells/ml) was found to be too low to result in cartilage tissue formation. However, in several cases, loosely bonded groups of beads and merged beads without visible boundaries were observed, implying that higher cell densities may lead to development of a continuous extracellular matrix. This study indicates the potentials of the packed bed bioreactor system in conjunction with alginate microbeads as cell carriers, for precise regulation of the cellular microenvironment in cartilage tissue engineering.
Shape Information From Shading: A Theory About Human Perception

I present evidence that people assume a simple, linear reflectance function when interpreting shading information. Using this reflectance function I derive a closed-form solution to the problem of extracting shape information from image shading. The solution does not employ an assumption about surface smoothness and so is directly applicable to complex natural surfaces such as hair or cloth. A simple biological mechanism is proposed to implement this recovery of shape. It is shown that this simple mechanism can also extract significant shape information from line drawings.