Miracle-dz/UniFAR-FTUs huggingface dataset:
A review of business process mining: state-of-the-art and future trends

Purpose – This paper seeks to examine the area of business process mining, providing an overview of state‐of‐the‐art techniques. An outline of the main problems experienced in the practice of process mining is given along with reference to work that addresses the most challenging issues experienced in this field. This paper also aims to examine the application of soft computing techniques to process‐mining problems.Design/methodology/approach – This paper is based on a comprehensive review of literature covering more than 50 research papers. These papers are analysed to identify current trends and future research directions in the field.Findings – Process‐mining techniques are now becoming available as graphical interface‐driven software tools, where flow diagram representations of processes may be manipulated as part of the mining task. A significant number of papers employ mining heuristics to aid in the task of process discovery. Soft computing algorithms are increasingly being investigated to aid the .
Techniques for Automated Test Cases Generation: A Review

Generation of test cases is challenging part of software testing phase. Test cases must have ability to cover more test objective features i.e., achieve more test coverage. The different techniques for automatic generation of test cases find small set of test cases reduce human efforts as well as cost of software testing and produce most efficient and effective testing of software product. This survey gives overview of different techniques of automatic test cases generation.
New method for extraction of MOSFET parameters

A new method for the extraction of the MOSFET parameters is presented in this letter. The method, which relies on combining drain current and output conductance characteristics, enables reliable values of the threshold voltage V/sub th/, mobility /spl mu//sub 0/ and the mobility attenuation coefficient /spl theta/ to be obtained. Extracted results have been shown in good agreement with that of the second-derivative method, showing the validity of our presented method.
Deciphering the MHC-associated peptidome: a review of naturally processed ligand data

ABSTRACT Introduction: The availability of big data sets (‘OMICS’) has greatly impacted fundamental and translational science. High-throughput analysis of HLA class I and II associated peptidomes by mass spectrometry (MS) has generated large datasets, with the last decade witnessing tremendous growth in the breadth and number of studies. Areas covered: For this, we first analyzed naturally processed peptide (NP) data captured within the IEDB to survey and characterize the current state of NP data. We next asked to what extent the NP data overlap with existing T cell epitope and MHC binding data. Expert commentary: The current collection of NP data represents a large and diverse set of class I/II peptides mostly derived from self-antigens. These data overlap only marginally with existing immunogenicity and binding data and it is thus difficult to ascertain the correspondence between the different assay methodologies. This highlights a need for unbiased studies benchmarking in model antigen systems how well MHC binding and NP data predicts immunogenicity. Going forward, efforts at generating an integrated process for capturing all NP, curating associated metadata and accessing NP data from an immunological viewpoint will be important for development of novel methods for identifying optimal target antigens and for class I and II epitope prediction.
Diagnosis, therapy and control of diabetes mellitus in children and adolescents.

The following recommendations are directed to all professional and vocational groups which take care of and support children and adolescents with diabetes, as well as their families. It is also directed to higher level organisations, such as health insurers, which deal with diabetes. This guideline concentrates on the specifics for this age group which are not described in the DDG’s general guidelines for the therapy of type 1 diabetes, or are described there, but somewhat differently [1]. As stated in the specifications of the health ministries of Germany’s states and in keeping with the current practice of many clinics, this paediatric guideline applies to all diabetes patients who are not yet 18 years of age. In individual clinical cases this guideline can also be used for young adults.
Two-dimensional mathematical model for Heat Assisted WAG with Chemical Additives for heavy oil recovery

This paper is an extension of previous work [1] and describe a two — dimensional (2-D) mathematical model, developed to simulate the heavy oil recovery process through the use of Heat Assisted WAG with Chemical Additives to reduce viscous fingering and gas override occurrence, which limits the efficiency of the WAG process. In this study we present a 2-D compositional mathematical model formulation and numerical solution for the process, with incorporating the important physical phenomena occurring during the process. The fully implicit finite difference approximation was used to convert the partial differential equation of the model into algebraic equations. The non linear Newtown-Raphson method was used for the solution of the resulting equations. The Jacobian of the residual equations was evaluated. The description of 2-D developed model discussed here will be useful to study the viscous fingering and gas override predictive models.
EFFECTIVE DEME SIZES DURING LONG‐TERM EVOLUTION ESTIMATED FROM RATES OF CHROMOSOMAL REARRANGEMENT

Closely related species often differ karyotypically due to the fixation of chromosomal translocations and inversions which are generally deleterious when heterozygous but have normal fitnesses when homozygous (White, 1973; Muller, 1954, 1956). The fixation of such chromosomal rearrangements requires small population sizes, because they are selected against when in the minority but favored when in the majority, and hence they can become established in a local area only through random genetic drift. Naturalists have long known that most species exist in subdivided populations where each individual has a limited number of potential mates; and recent biogeographic studies, especially on islands, have emphasized the high turnover rates of local populations by extinction and colonization (Simberloff, 1974; Spight, 1974). The present paper develops population genetic models to determine how the fixation rates of negatively heterotic chromosomal rearrangements are influenced by the spontaneous occurrence rates, strengths of selection against heterozygotes, the effective size of demes (or local populations), interdeme migration rates, local extinction and colonization, and other factors. Data on chromosomal rearrangements concerning spontaneous occurrence, selection coefficients, and fixation rates in phylogeny are then used to draw inferences about the breeding structure of species during longterm evolution, particularly the effective size of demes. The effective size of a population through time, Ne, is the number of breed-
Holmgren and Wohl ] art-- Mast Cells in Rat Sarcomas

The mast cells described by Ehrlich (6) are characterized by granules showing a so-called true metachromasia. Using as a basis Lison's statement (22) that this color reaction is typical of macromolecular sulphuric ester compounds and Jorpes' (17) demonstration that heparin is a mucoitin ester sulphuric acid showing a distinct metachromasia, Holmgren and Wilander (11) proved the mast cell granules to consist of a material with the same properties as heparin. These authors were able to isolate 22 mgm. of active heparin from 10 gin. of mast-cell-rich capsule of cow liver, whereas preparations of mast-cell-poor capsule of lamb liver proved to be inactive. Jorpes, Holmgren and Wilander (19) also confirmed the conception of mast cells as bearers of mucoitin ester sulphuric acid (heparin). Later this was corroborated by Hirth (10). Wilander (33) in a more comprehensive treatise on the nature of heparin demonstrated the mast cells to be the bearers of heparin. Mast cells are found exclusively in connective tissue, in rather variable amounts within the different parts of the body. Ehrlich had already emphasized that these cells occur chiefly in the vicinity of blood vessels. For bibliographical notes pertaining to mast cells, see Lehner (20), Holmgren and Wilander (11) and Michels (25). The pathology of mast cells seems still to be only partially recognized. Maximow (24) states that mast cells change their appearance during inflammation. Some are said to burst, and their granules are found in the tissues. Maximow also emphasizes that the new tissue is free from mast cells. Nakashima agrees with Maximow and stresses the fact that during the degeneration of mast cells the granules lose their metachromasia. In addition, Ernst (8) describes morphologic changes of mast cells during the first hours of the inflammatory process. The appearance of mast cells in tumors of various kinds has been dealt with by many authors. Sylv6n (31) described the appearance of mast cells in sarcoma of connective tissue origin. He emphasized that the largest number of these cells has "always been demonstrated within the pe-
Novel mutations in cholangiocarcinoma with low frequencies revealed by whole mitochondrial genome sequencing.

BACKGROUND Mitochondrial DNA (mtDNA) mutations have been shown to be associated with cancer. This study explored whether mtDNA mutations enhance cholangiocarcinoma (CCA) development in individuals. MATERIALS AND METHODS The whole mitochondrial genome sequences of 25 CCA patient tissues were determined and compared to those of white blood cells from the corresponding individuals and 12 healthy controls. The mitochondrial genome was amplified using primers from Mitoseq and compared with the Cambridge Reference Sequence. RESULTS A total of 161 mutations were identified in CCA tissues and the corresponding white blood cells, indicating germline origins. Sixty-five (40%) were new. Nine mutations, representing those most frequently observed in CCA were tested on the larger cohort of 60 CCA patients and 55 controls. Similar occurrence frequencies were observed in both groups. CONCLUSIONS While the correspondence between the cancer and mitochondrial genome mutation was low, it is of interest to explore the functions of the missense mutations in a larger cohort, given the possibility of targeting mitochondria for cancer markers and therapy in the future.
Eddy current damping analysis of laser marker using 3-D finite element method

This paper presents the numerical method for the damping analysis of a pendulum in a laser marker with the eddy current-brake. In this method, the eddy current analysis is coupled with two-dimensional (2-D) motion analysis employing the three-dimensional finite element method. The usefulness of this method is confirmed through the comparison with the computed and measured results of the 2-D damping trajectory of the pendulum
Cross-layer optimization for IEEE 802.11 DCF in fading channels

An assumption of the traditional layered protocol architecture is that all layers can be operated and optimized independently. Unfortunately, this assumption is not satisfied in wireless networks because wireless links introduce interdependence between physical (PHY) and upper layers. This paper investigates the impact of channel conditions on the performance of IEEE 802.11 DCF and proposes cross-layer optimization and design approach to improve the performance of DCF in fading channels. In this paper, a novel fade-induced packet error rate expressions based on fading statistics and error correction capability are developed. Based on these results, we propose a cross-layer analytical model to analyze the performance of IEEE 802.11 DCF in fading channels. The impact of channel conditions on the DCF performance is revealed.
Minimal residual disease detection in mantle cell lymphoma: methods and significance of four-color flow cytometry compared to consensus IGH-polymerase chain reaction at initial staging and for follow-up examinations

Multicolor flow cytometry is increasingly employed in the diagnosis and follow-up of mantle cell lymphoma. Findings of this study indicate that multicolor flow cytometry is a very valuable method for accurate initial staging of mantle cell lymphoma. Background The increasing application of multi-color flow cytometry assays for staging and follow-up in mantle cell lymphoma necessitates that the specificity and sensitivity of this technique are evaluated. Data from prospective clinical trials comparing the clinical applicability of flow cytometry to routine diagnostic methods and to polymerase chain reaction are currently lacking. Design and Methods We applied a standardized four-color flow cytometry assay to 281 prospectively collected peripheral blood and bone marrow samples from 98 patients with mantle cell lymphoma participating in a multi-center clinical trial and compared the results to those obtained with conventional clinical staging and consensus primer IGH-polymerase chain reaction. Results The maximum sensitivity of flow cytometry using light chain restriction in CD19+CD5+ subpopulations was 8.0×10−4 while flow cytometry that relied on immunophenotypic aberrations was less sensitive (2.4×10−3). Mantle cell lymphoma cells were detected in 87.3% of 110 pre-treatment samples from 84 patients by flow cytometry and in 94.5% by polymerase chain reaction. Eight out of 84 patients (9.5%) diagnosed clinically as having stage II or III disease showed peripheral blood or bone marrow involvement according to flow cytometry, thus documenting more advanced disease. At follow-up residual lymphoma cells were detected by flow cytometry and concordantly by polymerase chain reaction in 10/171 samples (5.8%); however, 31 follow-up samples (18.1%) were positive for minimal residual disease according only to polymerase chain reaction analysis. Conclusions The sensitivity of four-color flow cytometry is comparable to that of IGH-polymerase chain reaction at initial staging but is less sensitive at follow-up after immuno-chemotherapy. Both techniques are highly valuable methods for accurate initial staging.
Early Cambrian sipunculan worms from southwest China

We report the discovery of sipunculan worms from the Lower Cambrian Maotianshan Shale, near Kunming (southwest China). Their sipunculan identity is evidenced by the general morphology of the animals (sausage–shaped body with a slender retractable introvert and a wider trunk) and by other features, both external (e.g. perioral crown of tentacles, and hooks, papillae and wrinkle rings on the body surface) and internal (U–shaped gut, and the anus opening near the introvert–trunk junction). The three fossil forms (Archaeogolfingia caudata gen. et sp. nov., Cambrosipunculus tentaculatus gen. et sp. nov. and Cambrosipunculus sp.) have striking similarities to modern sipunculans, especially the Golfingiidae to which their evolutionary relationships are discussed. This study suggests that most typical features of extant sipunculans have undergone only limited changes since the Early Cambrian, thus indicating a possible evolutionary stasis over the past 520 Myr.
Depression, Guilt, and Tibetan Buddhism

Depression appears to be somewhat epidemic in the modern world. In prior empirical studies we found depression significantly associated with empathy-based guilt, empathic distress, and an overly active or misattributing moral system. In this study, we compared 98 Buddhists, who were primarily Tibetan meditation practitioners to 438 non-Buddhist, non-practicing community adults on a measure of depression along with measures of maladaptive guilt, empathic distress, anxiety and altruism. Our findings demonstrated that practitioners were significantly lower in depression, pathogenic guilt, anxiety, and empathic distress, and significantly higher on agreeableness, conscientiousness, openness to experience and compassionate altruism directed towards strangers. Intensity of practice significantly correlated with positive outcomes. In addition, we found that within the population of Tibetan Buddhist practitioners, those who endorsed the statement that the goal of meditation was other-focused (for the benefit of all sentient beings) were significantly lower in depression, empathic distress, and anxiety, and significantly higher in cognitive empathy (perspective-taking) compared to practitioners whose goal of meditation was self-focused.
Overcoming Treatment Resistance in Chronic Depression: A Pilot Study on Outcome and Feasibility of the Cognitive Behavioral Analysis System of Psychotherapy as an Inpatient Treatment Program

Background: The Cognitive Behavioral Analysis System of Psychotherapy (CBASP), initially developed as an outpatient treatment for chronic depression (CD), has been adapted as a multidisciplinary 12-week inpatient program for CD. Methods: Seventy inpatients with CD and treatment resistance were included in a noncontrolled trial. The Hamilton Depression Rating Scale served as the primary outcome measure. Prospective naturalistic follow-up assessments were conducted 6 and 12 months after discharge. Results: Dropout rate was 7.1%; 90.4% perceived the program as helpful. Pre-post comparisons yielded strong effect sizes; 75.7% of the intention-to-treat sample responded, and 40.0% remitted. Nonremission was associated with experiencing temporary deterioration of symptoms during treatment. After 6 months 75.0% and after 12 months 48.0% of patients sustained response. Conclusions: The CBASP program appears as a feasible acute treatment for treatment-resistant CD inpatients with promising outcome. However, the continuation of treatment after discharge should be optimized especially for patients with subjective deterioration during treatment.
Defining an Unified Meta Modeling Architecture for Deployment of Distributed Components-based Software Applications

Deployment is a complex process gathering activities to make applications operational after development, Today, the components approach and the distribution make deployment a very complex process. Many deployment tools exist but they are often built in an ad hoc way; i.e. specific to a technology or to an architecture and, covering partially the deployment life cycle. Hence there is an increased need for new techniques and tools to manage these systems. In this work, we focus on the deployment process describing a framework called UDeploy. UDeploy (Generic Deployment framework) is a framework based on a generic engine which permits firstly the carrying out of the planning process from meta-information related to the application and the infrastructure; secondly, the generation of specific deployment descriptors related to the application and the environment (i.e. the machines connected to a network where a software system is deployed); and finally the execution of a plan produced by means of deployment strategies. The work presented in this paper is focused on the presentation of a generic deployment architecture driven by metamodels and their transformations. In this respect, UDeploy is independent from any specific technology and, also from any specific platform characteristic.
Comparing Clinical Nurse Specialist Students’ Socialization Based on Magnet Employment

Purpose: The purpose of this study is to ascertain if clinical nurse specialist students differed on measures of professional socialization based on employment in a Magnet-oriented hospital. Design: A secondary analysis of data from a previous national study of the socialization of clinical nurse specialist students was used. Anticipatory socialization variables (nursing leadership, workplace exposure to the role, and preconceived impression of the role), mentorship by a clinical nurse specialist, and socialization outcomes (self-concept, perceived preparedness for practice, and nursing specialty certification) were explored. Methods: Data were divided into 2 groups: Magnet (n = 106) and non-Magnet (n = 119). Comparisons between the groups on researcher-designed items and the Professionalism and Work Ethic subscales of the Nurses Self-Description Form were analyzed. Results: The Magnet group was more likely to be exposed to the clinical nurse specialist role in the workplace. Overall, there were no group differences in socialization outcome measures; but in the subset of students with workplace exposure to the role, those with Magnet experience had higher professionalism self-concept scores. Conclusions: Magnet employment was not a significant socializing factor for nurses pursuing clinical nurse specialist education. The graduate program is likely the primary socializing agent for these students.
Work and Family As Constituents of Sense of Coherence

In this article, the authors focus on the intersection of the sense of coherence (SOC) and professional career in the light of qualitative data. They analyze the career descriptions written by young physicians in response to an open question in a survey questionnaire. In these narrative accounts, respondents who scored high on the SOC scale did not always orientate to work in a predictable way. Visiting narrative theoretization and feminist critique, the authors suggest a reflective survey style that seeks in the research process not so much an endeavor to reach a preexisting truth but, rather, a dialogue aimed at explaining the phenomenon at hand in a meaningful, agency-enabling way.
Immunohistochemical Localization of 2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase and Myelin Basic Protein in the Central Nervous System of the Jimpy and the Normal Mouse

Abstract: We describe the immunohistochemical localization of 2′,3′‐cyclic nucleotide 3′‐phosphodiesterase (CNPase) and myelin basic protein (MBP) in CNS of the jimpy mutant mouse which is characterized by dys‐ and demyelination. In controls, the CNPase and MBP were localized exclusively in white matter in the CNS. The jimpy mutant mice were severely affected: A very weak reaction was observed in the white matter. Very few CNPase‐ and MBP‐positive myelin sheaths were observed, and some degradation products were also observed after reaction with antisera against both CNPase and MBP. The immunohistochemical reaction in the jimpy mice showed a similar localization in both CNPase and MBP.
Integrating social networking sites in day-to-day learning scenarios: A Facebook based approach

In recent years, the number of users in social networking sites regularly increased. Especially younger people spend a tremendous time on social networking sites like Facebook, YouTube, Flickr, Google+ and many more. Since obviously this is the place on the World-Wide-Web where our students spent their spare time, we integrated social networking sites in our day-to-day learning scenarios. This is on the one hand to start working with our students where they feel comfortable, and on the other hand to allow to foster the communication among our students about the topic of the lectures.
A Three-Dimensional Fourth-Order ADI-FDTD Method and Its Application in Cavity Problems

Attention was focused on the three-dimensional fourth-order alternating-direction implicit finite-difference time-domain (3D 4th-order ADI-FDTD) method using the 4th-order spatial difference and the 2nd-order temporal difference. Firstly, the numerical formulation of the 4th-order ADI-FDTD method is presented. Secondly, the numerical dispersion relation is derived analytically. Moreover, the numerical dispersion is investigated as a function of mesh resolution and time step. Finally, several numerical examples for cavity problems are simulated. And it is found that the proposed method is more accurate than the 2nd-order ADI-FDTD method.