Miracle-dz/UniFAR-FTUs huggingface dataset:
Lateral Elbow Tendinopathy

Background: Lateral elbow tendinopathy is a common condition often diagnosed by ultrasound. Debate exists regarding which ultrasound findings correlate with disease severity and prognosis. Hypothesis: Sonographic predictors for tendon healing in patients with lateral elbow tendinopathy can be found by correlating initial ultrasound findings with subsequent changes in pain and functional disability scores after a period of nonoperative management. Study Design: Cohort study (prognosis); Level of evidence, 2. Methods: Sixty-two elbows (34 right, 28 left) in 62 patients (30 male, 32 female) with a clinical diagnosis of lateral elbow tendinopathy underwent sonographic evaluation of the common extensor origin after assessment with a validated outcome measure, the Patient-Rated Tennis Elbow Evaluation (PRTEE). After 6 months of nonoperative standardized treatment (physiotherapy with eccentric loading), the PRTEE questionnaire was repeated. Results: The mean pretreatment PRTEE was 78 (range, 51-97) and posttreatment score was 29 (range, 0-91). This difference in means was found to be significant (P < .0001). A positive correlation was identified between the presence of a lateral collateral ligament tear (P < .0001) and the size of the largest intrasubstance tear (P < .0001) and poor outcome. A negative correlation was identified with amount of hypoechogenicity (P = .0009). No correlation was found with age, sex, side, duration of symptoms, thickness of tendon, or amount of neovascularity. Conclusion: The size of intrasubstance tears and presence of a lateral collateral ligament tear on ultrasound can be used to assess lateral elbow tendinopathy severity, indicate those who may not respond to nonoperative therapy, and potentially guide more invasive treatment. Those patients with a large intrasubstance tear or tears identified on ultrasound are less likely to respond to nonoperative treatment. Presence of neovascularity has little correlation with change in pain severity or functional disability and may be a poor predictor of prognosis.
P300 and recall in an incidental memory paradigm.

In previous research Karis, Fabiani, and Donchin (1984) found a relationship between the amplitude of the P300s elicited by words and subsequent recall performance. Words later recalled elicited larger P300s than words later not recalled. However, this relationship was dependent on the mnemonic strategies used by the subjects. There was a strong relationship between P300 amplitude and recall when rote rehearsal strategies were used, but when subjects used elaborative strategies the relationship between P300 amplitude and recall was not evident. In the present experiment we employed an incidental memory paradigm to reduce the use of rehearsal strategies. An “oddball’ task consisting of a series of names was presented, and subjects were required to count either the male or the female names. Event-related brain potentials were recorded to the presentation of each name. Following the oddball task, subjects were asked, unexpectedly, to recall as many names as possible. The names that were recalled had elicited, on their initial presentation, larger P300s than names not recalled. Thus, these results confirm our hypothesis: when elaborative rehearsal strategies are not used, the relationship between P300 and memory emerges more consistently. Our data provide support for a “context updating’ hypothesis of the functional significance of the P300.
Feasibility and Effectiveness of Electrochemical Dermal Conductance Measurement for the Screening of Diabetic Neuropathy in Primary Care. Decoding Study (Dermal Electrochemical Conductance in Diabetic Neuropathy)

Diabetes mellitus (DM) is the leading cause of polyneuropathy in the Western world. Diabetic neuropathy (DNP) is the most common complication of diabetes and is of great clinical significance mainly due to the pain and the possibility of ulceration in the lower limbs. Early detection of neuropathy is essential in the medical management of this complication. Early unmyelinated C-fiber dysfunction is one of the typical findings of diabetic neuropathy and the first clinical manifestation of dysfunction indicating sudomotor eccrine gland impairment. In order to assess newly developed technology for the measurement of dermal electrochemical conductance (DEC), we analyzed the feasibility and effectiveness of DEC (quantitative expression of sudomotor reflex) as a screening test of DNP in primary health care centers. The study included 197 people (with type 2 diabetes, prediabetes and normal tolerance) who underwent all the protocol tests and electromyography (EMG). On comparing DEC with EMG as the gold standard, the area under the receiver operating characteristic (ROC) curve (AUC, area under the curve) was 0.58 in the whole sample, AUC = 0.65 in the diabetes population and AUC = 0.72 in prediabetes, being irrelevant in subjects without glucose disturbances (AUC = 0.47). Conclusions: In usual clinical practice, DEC is feasible, with moderate sensitivity but high specificity. It is also easy to use and interpret and requires little training, thereby making it a good screening test in populations with diabetes and prediabetes. It may also be useful in screening general populations at risk of neuropathy.
Modeling the Effects of Climate Change on Surface Ozone during Summer in the Yangtze River Delta Region, China

Future climate change can impact ozone concentrations by changing regional meteorological factors related to ozone (O3) pollution. To better understand the variations of meteorological factors and their effects on O3 formation processes under future climate conditions, we model the present and the future meteorology and air quality in summer over the Yangtze River Delta (YRD) region by using the Weather Research and Forecasting Model with Chemistry module (WRF/Chem), which is driven by the outputs of Community Climate System Model version 4 (CCSM4). The simulations predict that solar radiation, 2-m air temperature, and wind speed increase in the daytime over most of the YRD region. Absolute humidity and precipitation increase in the north and decrease in the south, while the planetary boundary layer height (PBLH) has an opposite change pattern displaying a decrease in the north and an increase in the south. The southerly wind will be strengthened in the daytime. At night, the change patterns of the meteorological factors are similar to the daytime but with small variations. Meanwhile, O3 and its precursors all increase in the north and decrease in the south. The increases of NOx, volatile organic compounds (VOC), and CO are related with the decreases of PBLH and the input effect of stronger southerly wind, while the decreases are attributed to the output effect of the stronger southerly wind. During the daytime, the increase of surface O3 in the north is dominated by the chemical processes related with the increases of solar radiation, air temperature, and O3 precursors. The decrease of surface O3 in the south is mainly caused by the transport process changing with the strengthened southerly wind. At night, the surface O3 changing the amplitude is less than the daytime. The less O3 variations at night can be attributed to an O3 titration reaction with NO, the changes in NOx concentrations, and the increases of nocturnal PBLH. With the aid of H2O2/HNO3, O3 formation in the YRD region is found to be easily affected by NOx in the future. The findings can help to understand the changing trend of O3 in the YRD region and can propose reasonable pollution control policies.
Availability and performance of image-based, non-contact methods of monitoring heart rate, blood pressure, respiratory rate, and oxygen saturation: a systematic review

Objective: Over the last 15 years, developments in camera technology have coincided with increased availability and affordability. This has led to an increasing interest in using these technologies in healthcare settings. Image-based monitoring methods potentially allow multiple vital signs to be measured concurrently using a non-contact sensor. We have undertaken a systematic review of the current availability and performance of these monitoring methods. Approach: A multiple database search was conducted using MEDLINE, Embase, CINAHL, Cochrane Library, OpenGrey, IEEE Xplore Library and ACM Digital Library to July 2018. We included studies comparing image-based heart rate, respiratory rate, oxygen saturation and blood pressure monitoring methods against one or more validated reference device(s). Each included study was assessed using the modified GRRAS criteria for reporting bias. Main results: Of 30 279 identified studies, 161 were included in the final analysis. Twenty studies (20/161, 12%) were carried out on patients in clinical settings, while the remainder were conducted in academic settings using healthy volunteer populations. The 18–40 age group was best represented across the identified studies. One hundred and twenty studies (120/161, 75%) estimated heart rate, followed by 62 studies (62/161, 39%) estimating respiratory rate. Fewer studies focused on oxygen saturation (11/161, 7%) or blood pressure (6/161, 4%) estimation. Fifty-one heart rate studies (51/120, 43%) and 24 respiratory rate studies (24/62, 39%) used Bland–Altman analysis to report their results. Of the heart rate studies, 28 studies (28/51, 55%) showed agreement within industry standards of 5 beats per minute. Only two studies achieved this within clinical settings. Of the respiratory rate studies, 13 studies (13/24, 54%) showed agreement within industry standards of 3 breaths per minute, but only one study achieved this in a clinical setting. Statistical analysis was heterogeneous across studies with frequent inappropriate use of correlation. The majority of studies (99/161, 61%) monitored subjects for under 5 min. Three studies (3/161, 2%) monitored subjects for over 60 min, all of which were conducted in hospital settings. Significance: Heart rate and respiratory rate monitoring using video images is currently possible and performs within clinically acceptable limits under experimental conditions. Camera-derived estimates were less accurate in the proportion of studies conducted in clinical settings. We would encourage thorough reporting of the population studied, details of clinically relevant aspects of methodology, and the use of appropriate statistical methods in future studies. Systematic review registration: PROSPERO CRD42016029167 Protocol: https://systematicreviewsjournal.biomedcentral. com/articles/10.1186/s13643-017-0615-3
Clustering Based on MultiView Diffusion Maps

We consider a reduced dimensionality representation based on multiple views of the same underlying process. These multiple views can be obtained, for example, using several different modalities, measured with different instrumentation or generated based on different methods of feature extractions. Our framework is based on a cross-view random walk process which is restrained to hop between the different views in each time step. The random walk model is constructed using the intrinsic relation within each view as well as the mutual relations between views. Within this framework, multiview diffusion distances are defined which lead to reduced representations for each view. The reduced representations are exploited to perform clustering. The applicability of the multiview approach for clustering is demonstrated on both artificial and real data.
Cistrome-GO: a web server for functional enrichment analysis of transcription factor ChIP-seq peaks

Abstract Characterizing the ontologies of genes directly regulated by a transcription factor (TF), can help to elucidate the TF’s biological role. Previously, we developed a widely used method, BETA, to integrate TF ChIP-seq peaks with differential gene expression (DGE) data to infer direct target genes. Here, we provide Cistrome-GO, a website implementation of this method with enhanced features to conduct ontology analyses of gene regulation by TFs in human and mouse. Cistrome-GO has two working modes: solo mode for ChIP-seq peak analysis; and ensemble mode, which integrates ChIP-seq peaks with DGE data. Cistrome-GO is freely available at http://go.cistrome. org/.
Cisplatin-Induced Ototoxicity in Rats Is Driven by RIP3-Dependent Necroptosis

Cisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent necroptosis in cisplatin-induced ototoxicity in vitro and in vivo. Sprague–Dawley rats (SD, 8 week) were treated via intraperitoneal (i.p.) injection with cisplatin (16 mg/kg for 1 day), and their hearing thresholds were measured by the auditory brainstem response (ABR) method. Hematoxylin and eosin (H & E) staining, immunohistochemistry, and western blots were performed to determine the effect of cisplatin-induced ototoxicity on cochlear morphology. Inhibitor experiments with necrostatin 1 (Nec-1) and Z-VAD were also performed in HEI-OC1 cell line. H&E stains revealed that the necroptotic changes were increased in the organ of Corti (OC) and spiral ganglion neurons (SGNs). Moreover, immunohistochemistry and western blot analysis showed that cisplatin treatment increased the protein levels of RIP3 in both OCs and SGNs. The treatment of Nec-1, a selective RIP1 inhibitor, resulted in markedly suppression of cisplatin-induced cell death in HEI-OC1 cells, whereas Z-VAD treatment did not change the cisplatin-induced cell death. Our results suggest that RIP3-dependent necroptosis was substantial in cisplatin-induced ototoxicity; inner cochlear regions, the OCs, and SGNs were especially sensitive to necroptosis.
Edge-Computing Video Analytics for Real-Time Traffic Monitoring in a Smart City

The increasing development of urban centers brings serious challenges for traffic management. In this paper, we introduce a smart visual sensor, developed for a pilot project taking place in the Australian city of Liverpool (NSW). The project’s aim was to design and evaluate an edge-computing device using computer vision and deep neural networks to track in real-time multi-modal transportation while ensuring citizens’ privacy. The performance of the sensor was evaluated on a town center dataset. We also introduce the interoperable Agnosticity framework designed to collect, store and access data from multiple sensors, with results from two real-world experiments.
Second primary cancers in non‐Hodgkin lymphoma: Family history and survival

Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses and family history of cancer may be a risk factor for SPCs. Using the Swedish Family‐Cancer Database on non‐Hodgkin lymphoma (NHL), we assessed the influence of family history on risk of SPCs and of SPCs on survival. NHL patients were identified from the years 1958 to 2015 and generalized Poisson models were used to calculate relative risks (RRs) for SPCs and familial SPCs. Among 14,393 NHL patients, a total of 1,866 (13.0%) were diagnosed with SPC. Familial risk of nine particular cancers was associated with risks of these cancers as SPCs, with twofold to fivefold increase in RRs. At the end of a 25‐year follow‐up period, the survival probability for persons with SPC was only 20% of that for patients without SPC; the hazard ratio for SPC was 1.59 (95% CI: 1.46–1.72). Survival could be predicted by the prognostic groups based on first cancers and HRs increase systematically with worse prognosis yielding a trend of p = 4.6 × 10−5. SPCs had deleterious consequences for survival in NHL patients. Family history was associated with increasing numbers of SPCs. Prevention of SPCs and their early detection is an important target in the overall strategy to improve survival in NHL patients. Counseling for avoidance of risk factors and targeted screening based on family history are feasible steps in risk reduction.
Key Messages in an Early Childhood Obesity Prevention Intervention: Are They Recalled and Do They Impact Children’s Behaviour?

Knowledge of the impact of health messages as an intervention strategy is sparse. The aim of this study was to explore recall and use of health behaviour messages among mothers, and whether recall is associated with child health behaviours. Intervention group data from the 15 months Melbourne Infant Feeding, Activity and Nutrition Trial (InFANT) were used (n = 127, children 4 months at commencement). Mothers recalled (unprompted then prompted) at 2 and 3.5 years post-intervention six key messages used in the program, and reported whether they had used them. Children’s food intake was measured by three days of 24-h recall; physical activity by accelerometers; and television viewing by parent report. Unprompted recall ranged between 1–56% across messages and follow-up points, and 37–90% for prompted recall. The most commonly recalled messages “tap into water”, “parents provide, kids decide” and “color every meal with fruit and veg” were also most commonly used. There were few associations between recall and children’s health behaviours. Given the association between recall and reported use, it is important to plan messages so they resonate well with the target group and its needs. Messages should be used as one of multiple strategies within health promotion programs.
Plastic changes in brain morphology in relation to learning and environmental enrichment in the guppy (Poecilia reticulata)

ABSTRACT Despite the common assumption that the brain is malleable to surrounding conditions mainly during ontogeny, plastic neural changes can occur also in adulthood. One of the driving forces responsible for alterations in brain morphology is increasing environmental complexity that may demand enhanced cognitive abilities (e.g. attention, memory and learning). However, studies looking at the relationship between brain morphology and learning are scarce. Here, we tested the effects of both learning and environmental enrichment on neural plasticity in guppies (Poecilia reticulata), by means of either a reversal-learning test or a spatial-learning test. Given considerable evidence supporting environmentally induced plastic alterations, two separate control groups that were not subjected to any cognitive test were included to account for potential changes induced by the experimental setup alone. We did not find any effect of learning on any of our brain measurements. However, we found strong evidence for an environmental effect, where fish given access to the spatial-learning environment had larger relative brain size and optic tectum size in relation to those exposed to the reversal-learning environment. Our results demonstrate the plasticity of the adult brain to respond adaptively mainly to environmental conditions, providing support for the environmental enhancement theory. Summary: Modifications of the brain can occur as a form of adaptation to environmental conditions. Environmental enrichment was found to influence relative brain size in guppies.
Radar emitter signal classification based on mutual information and fuzzy support vector machines

In this paper, a novel method based on mutual information and fuzzy support vector machines for recognizing radar emitter signals is introduced. The radar signal waveforms are the linear frequency modulation (LFM), frequency-coded signals, BPSK and QPSK. The wavelet ridges and higher-order statistics are used to extract signal features. Mutual information measures is used to reduce the redundant components from the feature vectors set. Then these discriminative and low dimensional features achieved are fed to a fuzzy support vector machine classifier for multi-class patter recognition. In simulation, the classifier attains over 78% overall average correct classification rate. Experimental results show that the proposed methodology is efficient for different complex radar signals detection and classification.
Quality of Life and Health: Influence of Preparation for Retirement Behaviors through the Serial Mediation of Losses and Gains

The dynamic theory of resources is a recent approach that provides a theoretical framework for understanding, forecasting, and examining the relationships between people’s resources and their adaptation to retirement. This article focuses on the transition to retirement in order to better understand how retirees’ perceptions of their gains and losses when they approach retirement significantly explain their well-being after retirement. Moreover, we explore the relationship between people’s preparation behaviors before retirement (T1) and their quality of life and health after retirement (T3), taking into consideration the mediating role of perceived gains and losses in retirement (T2). This study was carried out with a sample of Spanish workers (N = 244) who were employed at T1 and had retired at T2 and T3. The results support the assertion that losses explain well-being better than gains. In addition, some specific losses showed a greater explanatory power for quality of life and health than others. The implications are discussed with a view to understanding retirement and the design of interventions.
Experimental Demonstration of MmWave Vehicle-to-Vehicle Communications Using IEEE 802.11ad

Millimeter wave (mmWave) vehicle-to-vehicle (V2V) communications has received significant attention as one of the key applications in 5G technology, which is called as Giga-V2V (GiV2V). The ultra-wide band of the GiV2V allows vehicles to transfer gigabit data within a few seconds, which can achieve platooning of autonomous vehicles. The platooning process requires the rich data of a 4K dash-camera and LiDAR sensors for accurate vehicle control. To achieve this, 3GPP, a global organization of standards that provides specifications for the 5G mobile technology, is developing a new standard for GiV2V technology by extending the existing specification for device-to-device (D2D) communication. Meanwhile, in the last decade, the mmWave spectrum has been used in the wireless local area network (WLAN) for indoor devices, such as home appliances, based on the IEEE 802.11ad (also known as Wireless Gigabit Alliance (WiGig)) technology, which supports gigabit wireless connectivity of approximately 10 m distance in the 60-GHz frequency spectrum. The WiGig technology has been commercialized and used for various applications ranging from Internet access points to set-top boxes for televisions. In this study, we investigated the applicability of the WiGig technology to the GiV2V communications through experiments on a real vehicular testbed. To achieve this, we built a testbed using commercial off-the-shelf WiGig devices and performed experiments to measure inter-vehicle connectivity on a campus and on city roads with different permitted vehicle speeds. The experimental results demonstrate that disconnections occurred frequently due to the short radio range and the connectivity varied with the vehicle speed. However, the instantaneous throughput was sufficient to exchange large data between moving vehicles in different road environments.