Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluating Angular Accuracy of Wrist-based Haptic Directional Guidance for Hand Movement

Haptic guidance for the hand can offer an alternative to visual or audio feedback when those information channels are overloaded or inaccessible due to environmental factors, vision impairments, or hearing loss. We report on a controlled lab experiment to evaluate the impact of directional wrist-based vibro-motor feedback on hand movement, comparing lower-fidelity (4-motor) and higher-fidelity (8-motor) wristbands. Twenty blindfolded participants completed a series of trials, which consisted of interpreting a haptic stimulus and executing a 2D directional movement on a touchscreen. We compare the two conditions in terms of movement error and trial speed, but also analyze the impact of specific directions on performance. Our results show that doubling the number of haptic motors reduces directional movement error but not to the extent expected. We also empirically derive an apparent lower bound in accuracy of ~25° in interpreting and executing on the directional haptic signal.
Optimization of paeonol-loaded microparticle formulation by response surface methodology

Abstract In this study, a central composite rotatable design based on response surface methodology (RSM) was employed to design and formulate an appropriate paeonol microparticle formulation. Five levels of a three-factor, rotatable, central composite design were used to evaluate the critical formulation variables. The optimum conditions for preparing paeonol-loaded microparticles were predicted to be: polyvinyl alcohol (PVA) content (2.84%), the ratio of drug to polymer (6.88) and the stirring rate (1007.59 rpm). The optimized responses for production yield and loading efficiency were found to be 68.86% and 55.90%, respectively, and the particle size were 23.27 ± 0.76 µm and the sorting coefficient (σ) was 0.732. Furthermore, in vitro release study suggested that microparticle could be a suitable delivery system in treating skin disease for its sustained release of drug. In conclusion, RSM can be successfully used to optimize the effect of formulation variables.
Millimeter wave measurement of the TM mode cutoff for EBG structures fabricated in LTCC for antenna applications

This paper presents characterization of low temperature co-fired ceramic (LTCC) based electromagnetic bandgap (EBG) structures, and a test method to measure the TM mode cutoff frequency at millimeter wave frequencies. This test method differs from prior art in that the TM mode surface wave launchers are fabricated in the same LTCC module as the EBG structure under test to realize a compact and repeatable test vehicle. A pair of two port transmission measurements will experimentally yield the TM mode cutoff frequency. This frequency defines the lower bound for the surface wave bandgap. The TM mode cutoff frequency is a very important parameter where EBG structures are integrated into millimeterwave LTCC antennas because this cutoff frequency must be lower than the antenna's operational frequency range. This proposed test method may be used with any open EBG structure which exhibits a TM mode cutoff frequency.
Incipient Renal Impairment as a Predictor of Subclinical Atherosclerosis in HIV-Infected Patients

Introduction:HIV-infected patients present increased incidence of cardiovascular disease (CVD). Although incipient kidney function impairment has been associated with CVD in the general population, this association has not been properly addressed in HIV-infected patients. We assessed the relationship between incipient renal impairment (IRI) and subclinical atherosclerosis in HIV-infected patients. Methods:Estimated glomerular filtration rate (eGFR), carotid intima-media thickness (cIMT), and cardiovascular biomarkers were measured in 145 HIV-infected patients. IRI was defined as a composite variable: eGFR <90 mL/min, rate of eGFR decrease >3% annually over a period of 3 years, and albumin/creatinine urine ratio above the median (≥5 mg/g). Individuals with a cIMT ≥75th percentile or plaque were classified as having subclinical atherosclerosis. Results:Ninety-five patients (64.1%) met the criteria for IRI. As for HIV-related factors, patients with IRI more frequently had lipodystrophy (41.3% vs. 21.6%; P = 0.017), a lower CD4 lymphocyte nadir [210 (125–343) vs. 302 (178–408) cells/mL; P = 0.046], and longer exposure to nucleoside reverse transcriptase inhibitors [187 (84–259) vs. 104 (34–170) months; P = 0.001], to nonnucleoside reverse transcriptase inhibitors [32 (7–77) vs. 20 0–40) months; P = 0.043], and to protease inhibitors [42 (0–115] vs. 2.5 (0-59) months; P = 0.007]. Patients with IRI more frequently had subclinical atherosclerosis (40.7% vs. 13.7%; odds ratio: 4.3; 95% confidence interval: 1.8 to 10.6; P = 0.001), even after adjustment for cardiovascular and HIV-related parameters (odds ratio: 3.8; 95% confidence interval: 1.3 to 11; P = 0.012). Conclusions:The presence of IRI is an independent predictor of increased cIMT in HIV-infected patients and may help to identify patients with subclinical atherosclerosis and, therefore, increased risk of CVD.
Transcription Initiation Activity of Adenovirus Left-End Sequence in Adenovirus Vectors with E1 Deleted

ABSTRACT We analyzed the transcription initiation activity of the left-end sequence (first 342 bp) of the adenovirus genome in the context of an adenovirus vector with E1 deleted in in vitro and in vivo gene transfer models. While nucleotide sequences 1 to 190 and 1 to 342 showed strong activity in three out of three lung cancer cell lines, nucleotide sequence 1 to 103 showed limited activity in H358, cells which show characteristics of type 2 alveolar cells. In vivo, the transcription initiation activities of nucleotide sequence 1 to 103 in the liver and the lung were minimal, while nucleotide sequences 1 to 190 and 1 to 342 showed strong activity comparable to that of the cytomegalovirus promoter. Further understanding of the transcription initiation activity of the left-end sequence of the adenovirus genome should lead to optimization of adenovirus vectors.
Effect of blood donation on maximal oxygen consumption.

AIM This study determined the effect of donating one unit of blood on various physiological parameters associated with a VO2(max) test. METHODS Ten healthy, male subjects (23+/-4 years, 178+/-7.6 cm, 74.4+/-12.3 kg) completed a VO2(max) test 24 h before donating one unit of blood (~500 mL) and 24 h after donating blood. The Bruce protocol was used to determine the subjects' VO2(max). Physiological responses were measured at the end of the VO2(max) test. A repeated measures ANOVA was used to determine if there were significant (P<0.05) differences in the subjects' physiological responses between the VO2(max) before and after blood donation. RESULTS Significant differences were found in VO2(max) (mean+/-SD, 3.18+/-0.74 vs 2.87+/-0.53 L.min(-1)), cardiac output (Q, 25+/-5 vs 22.5+/-3.3 L.min(-1)), stroke volume (SV, 134+/-37 vs 121+/-22 mL.beat(-1)), delivery of oxygen (DO(2), 5+/-. 87 vs 3.97+/-. 68 L.min(-1)), and hemoglobin concentration (Hb, 153+/-12 vs 135+/-16 gm.L(-1)). No significant changes were observed for heart rate (HR); arteriovenous oxygen difference (a-vO(2) diff), systolic blood pressure (SBP), and diastolic blood pressure (DBP). CONCLUSIONS These findings indicate that donating one unit of blood decreased VO2(max) due to the decrease in Q, which resulted from the decrease in SV since HR was unchanged. The lower VO2(max) along with the decrease in DO(2) would be expected to have a negative effect on athletic performance.
reveals global properties and specific subclasses Integrative annotation of human large intergenic noncoding RNAs Material

Material Supplemental http://genesdev.cshlp. org/content/suppl/2011/09/01/gad.17446611. DC1.html References http://genesdev.cshlp. org/content/25/18/1915.full. html#ref-list-1 This article cites 58 articles, 22 of which can be accessed free at: Open Access Open Access option. Genes & Development Freely available online through the Service Email Alerting click here. right corner of the article or Receive free email alerts when new articles cite this article sign up in the box at the top
Exploiting High-Order Information in Heterogeneous Multi-Task Feature Learning

Multi-task feature learning (MTFL) aims to improve the generalization performance of multiple related learning tasks by sharing features between them. It has been successfully applied to many pattern recognition and biometric prediction problems. Most of current MTFL methods assume that different tasks exploit the same feature representation, and thus are not applicable to the scenarios where data are drawn from heterogeneous domains. Existing heterogeneous transfer learning (including multi-task learning) approaches handle multiple heterogeneous domains by usually learning feature transformations across different domains, but they ignore the high-order statistics (correlation information) which can only be discovered by simultaneously exploring all domains. We therefore develop a tensor based heterogeneous MTFL (THMTFL) framework to exploit such high-order information. Specifically, feature transformations of all domains are learned together, and finally used to derive new representations. A connection between all domains is built by using the transformations to project the pre-learned predictive structures of different domains into a common subspace, and minimizing their divergence in the subspace. By exploring the high-order information, the proposed THMTFL can obtain more reliable feature transformations compared with existing heterogeneous transfer learning approaches. Extensive experiments on both text categorization and social image annotation demonstrate superiority of the proposed method.
Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells.

The Eph receptor tyrosine kinases and their membrane-tethered ephrin ligands provide critical guidance cues at points of cell-to-cell contact. It has recently been reported that the ephrin-B2 ligand is a molecular marker for the arterial endothelium at the earliest stages of embryonic angiogenesis, while its receptor EphB4 reciprocally marks the venous endothelium. These findings suggested that ephrin-B2 and EphB4 are involved in establishing arterial versus venous identity and perhaps in anastamosing arterial and venous vessels at their junctions. By using a genetically engineered mouse in which the lacZ coding region substitutes and reports for the ephrin-B2 coding region, we demonstrate that ephrin-B2 expression continues to selectively mark arteries during later embryonic development as well as in the adult. However, as development proceeds, we find that ephrin-B2 expression progressively extends from the arterial endothelium to surrounding smooth muscle cells and to pericytes, suggesting that ephrin-B2 may play an important role during formation of the arterial muscle wall. Furthermore, although ephrin-B2 expression patterns vary in different vascular beds, it can extend into capillaries about midway between terminal arterioles and postcapillary venules, challenging the classical conception that capillaries have neither arterial nor venous identity. In adult settings of angiogenesis, as in tumors or in the female reproductive system, the endothelium of a subset of new vessels strongly expresses ephrin-B2, once again contrary to earlier views that such new vessels lack arterial/venous characteristics and derive from postcapillary venules. While earlier studies had focused on a role for ephrin-B2 during the earliest embryonic stages of arterial/venous determination, our current findings using ephrin-B2 as an arterial marker in the adult challenge prevailing views of the arterial/venous identity of quiescent as well as remodeling adult microvessels and also highlight a possible role for ephrin-B2 in the formation of the arterial muscle wall.
Sequestration of mRNAs Modulates the Timing of Translation during Meiosis in Budding Yeast

ABSTRACT Starvation of diploid cells of the budding yeast Saccharomyces cerevisiae induces them to enter meiosis and differentiate into haploid spores. During meiosis, the precise timing of gene expression is controlled at the level of transcription, and also translation. If cells are returned to rich medium after they have committed to meiosis, the transcript levels of most meiotically upregulated genes decrease rapidly. However, for a subset of transcripts whose translation is delayed until the end of meiosis II, termed protected transcripts, the transcript levels remain stable even after nutrients are reintroduced. The Ime2-Rim4 regulatory circuit controls both the delayed translation and the stability of protected transcripts. These protected mRNAs localize in discrete foci, which are not seen for transcripts of genes with different translational timing and are regulated by Ime2. These results suggest that Ime2 and Rim4 broadly regulate translational delay but that additional factors, such as mRNA localization, modulate this delay to tune the timing of gene expression to developmental transitions during sporulation.
Querying and Mining Multigraphs

Avec des volumes de donnees et d’informations de plus en plus importants, des donnees de plus en plus complexes et fortement inter-reliees, l’extraction de connaissances reste un veritable defi. Les graphes offrent actuellement un support de representation efficace pour representer ces donnees. Parmi les approches existantes, les multi-graphes ont montre que leur pouvoir d’expression etait particulierement adapte pour manipuler des donnees complexes possedant de nombreux types de relations entre elles. Cette these aborde deux aspects principaux lies aux multigraphes : la recherche de sous graphes et la fouille de sous graphes frequents dans des multigraphes.Elle propose trois propositions dans le domaines du requetage et de la fouille de donnees.La premiere contribution s’inscrit dans la recherche de sous graphes et concerne l’isomorphisme de sous graphes dans des multigraphes. Cette approche peut, par exemple, etre appliquee dans de nombreux domaines d’applications comme l’analyse d’images satellites ou de reseaux sociaux. Dans la seconde, nous nous interessons aux graphes de connaissances et abordons la problematique de l’homorphisme de graphes dans des multigraphes RDF. Dans les deux contributions, nous proposons de nouvelles techniques d’indexations pour representer efficacement les informations contenues dans les multigraphes. La recherche des sous graphes tire avantage de ces nouveaux index et differentes heuristiques et optimisations sont egalement proposees pour garantir de bonnes performances lors de l’execution des requetes. La seconde contribution s’inscrit dans le domaine de la fouille de donnees et nous proposons un algorithme efficace pour extraire les multigraphes frequents. Etant donne l’espace de recherche a considerer, la recherche de motifs frequents dans des graphes est un probleme difficile en fouille de donnees. Pour parcourir efficacement l’espace de recherche encore plus volumineux pour les multigraphes, nous proposons de nouvelles techniques et methodes pour le traverser efficacement notamment en eliminant des candidats ou detectant a l’avance les motifs non frequents. Pour chacune de ces propositions de nombreuses experimentations sont realisees pour valider a la fois leurs performances et exactitudes en les comparant avec les approches existantes. Finalement, nous proposons une etude de cas sur des jeux de donnees issues d’images satellites modelisees sous la forme de multigraphe et montrons que l’application de nos propositions permet de mettre en evidence de nouvelles connaissances utiles.
Reading Online and Offline: Language Teachers' Perspectives

Reading online is different from reading offline. Are language teachersâ€™ strategies for reading electronic texts and reading printed texts different? Do language teachers have different attitudes toward reading printed texts and reading electronic texts, particularly web-based reading materials? Several groups of in-service language teachers enrolled in a postgraduate course on computer-assisted language learning offered by an Australian university were asked to respond to these questions in online discussion forums. This article presents data from the discussion forums and investigates the teachersâ€™ perspectives on online reading, while exploring the differences between online reading and offline reading and the advantages and disadvantages of the two forms of reading. Findings indicate that many teachers liked to download and print study materials for both physical and academic reasons. While most teachers preferred to read online for accessing study materials, they preferred to print out copies for more detailed reading of journal articles. These results have implications for language teacher education and professional development in e-learning environments.
CMOS CW tunable III–V microdisk LASERs for optical interconnects in integrated circuits

Full CMOS compatible microdisk LASERs have been fabricated on 200 mm SOI wafers. CW operation with a sub-mW threshold is obtained with low voltage operation. Coupling the microdisk to a pseudo cavity, formed by a photonic crystal and the coupled waveguide itself, we also demonstrate mode hopping and multimode emission thanks to an active control of its optical paths.
Levels of tau phosphorylation at different sites in Alzheimer disease brain

THE microtubule-associated protein tau is abnormally hyperphosphorylated in Alzheimer's disease (AD) brain. To date, 21 phosphorylated sites of tau have been identified. In the present study the levels of phosphorylation at Ser199/Ser202, Thr231/Ser235, Ser262/Ser356 and Ser396/Ser404 of tau in AD brain homogenate and its 100 000 × g supernatant were determined using radioimmuno-dot-blot assay. In homogenate, Ser199/Ser202 and Ser262/Ser356 were phosphorylated to similar level and were more phosphorylated than Thr231 or Ser396/Ser404. In supernatant, there was no significant difference in phosphorylated tau level among the investigated sites except for Thr231/Ser235 which was least phosphorylated. These results suggest that Ser199/Ser202 and Ser262/Ser356 are major sites of phosphorylation of tau in AD brain.
Diagnosis of Diabetic Retinopathy Disease Based on Edge Detection of Spiking Neural Network Based on Percolation Theory

oday, one of the problems that medical science is struggling with is the lack of systems for identifying, detecting and predicting various diseases that work accurately and practically. Diabetes is one of the diseases that has embroiled people in today's world because of failing to regard the biological issues. Diabetes has different types, one of which is diabetic retinopathy, one of the main dangers of which is loss of vision. Micro-aneurysms, which are red spots, are the first symptoms of the disease that occur in the retina. The most important issue in this area is the early diagnosis of retinopathy for person to keep his sight and postpone the consequences of this disease for a while. This research presents a new approach to detect and diagnose diabetic retinopathy by using mixed methods. The proposed approach has four stages. In the first step, pre-processing is done with the aim of eliminating the probabilistic noise and standardizing the input dataset. Afterwards, segmentation and edge detection operations are performed based on spiking neural network. In the following, the percolation method is used to reduce the dimensions, the selection and extraction of the characteristic, which in fact features, are the edges of the blood vessels and the intensity of the brightness at the edge. Diagnosis of retinopathy areas is also done based on the combination of two methods of spiking neural network and percolation.
Forecasting the air transport demand for passengers with neural modelling

The air transport industry firmly relies on forecasting methods for supporting management decisions. However, optimistic forecasting has resulted in serious problems to the Brazilian industry in the past years. In this paper, models based on artificial neural networks are developed for the air transport passenger demand forecasting. It is found that neural processing can outperform the traditional econometric approach used in this field and can accurately generalise the learning time series behaviour, even in practical conditions, where a small number of data points is available. Feeding the input nodes of the neural estimator with pre-processed data, the forecasting error is evaluated to be smaller than 0.6%.
Selecting new lecturers using the Analytical Hierarchy Process (AHP)

In the educational system, lecturers play important role in producing marketable graduates. This can be achieved by employing potentially competent lecturers. The process of selecting new lecturers in a public university in Malaysia involves three phases: academic qualification consideration, mock teaching and face-to-face interview. The eligible candidates will be shortlisted after performing the mock teaching session. Then, the shortlisted candidates will be called for the face-to-face interview. In this paper, we developed lecturer's selection model using Analytical Hierarchy Process (AHP), which uses both qualitative and quantitative decision making approaches. This model will consider all scores from the three phases in order to rank the candidates. The developed model contains 5 levels of hierarchy, starting with the goal (new lecturer), 3 types of interview, 13 criteria of the interview, 8 sub-criteria, and finally the candidates. The computation is done using Excel Spreadsheet.
Method of Load/Fault Detection for Loosely Coupled Planar Wireless Power Transfer System With Power Delivery Tracking

A method to determine various operating modes of a high-efficiency inductive wireless power transfer system which is capable of supporting more than one receiver is proposed. The three operating modes are no-load, safe, and fault modes. The detection scheme probes the transmitter circuitry periodically to determine the operating mode. For power saving, the transmitter is powered down when there is no valid receiver placed on the transmitting coil. If any conductive or magnetic object that can affect the total effective inductance of the transmitting coil is located nearby, the system will enter the fault mode and shut down the transmitter so that it will not be damaged. The safe mode is the nominal operation mode when the power transmission efficiency is high with minimum power loss and zero-voltage switching operation of the class-E transmitter is achieved. The determination of the operating mode is achieved by analyzing the transmitting coil voltage and supply current space, requiring no communication link between the transmitter and receiver. The linear relationship between the power delivery and the supply current can be used to calculate the power delivered to the load(s).