Miracle-dz/UniFAR-FTUs huggingface dataset:
Intensive Cardiovascular Examination regarding Blood pressure levels: Evaluation of Risk Groups. ICEBERG study

Objective. Assessment of total cardiovascular risk level is crucial for approaching hypertensive patients. Therefore, the aim of the Intensive/Initial Cardiovascular Examination regarding Blood pressure levels: Evaluation of Risk Groups (ICEBERG) study is to determine cardiovascular risk evaluation and stratification of subjects with high normal and high blood pressure (BP⩾130/85 mmHg), and to evaluate the impact of laboratory tests on this stratification. Methods. ICEBERG was an epidemiological study conducted at 20 university hospitals and 197 primary healthcare centers. A total of 10,313 patients, who were diagnosed with high BP and under antihypertensive treatment or not antihypertensive under treatment at least for the last 3 months were selected. Besides routine clinical evaluation, microalbuminuria (MAU) and high sensitive C‐reactive protein (hs‐CRP) tests, echocardiography (Echo) and carotid ultrasonography (USG) were performed in selected arms. The patients were stratified into low, moderate, high and very high added risk groups as described by the European Society of Hypertension/European Society of Cardiology Guidelines Committee (2003). Results. Upon routine evaluation, the percentage of “high and very high added cardiovascular risk” groups was between 51.2% and 60.7% in different study arms. This percentage increased to 62.9% by subsequent serum biochemistry assessment and to 76.2% by hs‐CRP test results. Switching upwards to “high and very high added risk” groups was around 6% when MAU results were used, with a 4.9% upwards switch to “high and very high added risk” groups when Echo was performed; this proportion increased by 6.8%, when carotid USG was taken into account. Conclusion. Cardiovascular risk evaluation by intensive cardiovascular examination including Echo and carotid USG provided more accurate risk stratification. Furthermore, a simple test to demonstrate presence of MAU usable at primary healthcare level will also help to evaluate the patient's risk profile better than routine assessment methods alone.
The place for individual conscience

From a liberationist, feminist, and Catholic point of view, this article attempts to understand the decision of abortion. People are constantly testing their principles and values against the question of abortion. Advances in technology, the rise of communitarianism and the rejection of individualism, and the commodification of children are factors in the way in which the abortion debate is being constructed in society. The paper offers solutions to end the ugliness of the abortion debate by suggesting that we would be able to progress further on the issue of abortion if we looked for the good in the opposing viewpoint. The article continues with a discussion of Catholics For a Free Choice's position on abortion, and notes firstly that there is no firm position within the Catholic Church on when the fetus becomes a person; secondly that the principle of probablism in Roman Catholicism holds that where the church cannot speak definitively on a matter of fact (in this case, on the personhood of the fetus), the consciences of individual Catholics must be primary and respected, and thirdly that the absolute prohibition on abortion by the church is not infallible. In conclusion, only the woman herself can make the abortion decision.
Determinants of housing price: data analysis of city Brno

This paper introduces determinants of housing price in the statutory city of Brno. The aim is to present several determinants and find the model which describes the relationship between determinants and housing price. We choose three types of variables as determinants: time, location and house characteristics. For the purpose of processing this paper realized prices were analysed (for the period between 2012:Q1 and 2015:Q2) for housing units located in different districts of Brno. Those three are then variables entered into hedonic price model. Hedonic price model is estimated using the method of ordinary least square. In conclusion this contribution sets out the factors that influence the buyer's choice of new house.
Judicial Perspectives of Domestic Violence Courts

5 Chapter 1: Introduction 6 The Evolution of Domestic Violence Courts 7 Theoretical Basis of Domestic Violence Courts 10 Definition of a Specialized Domestic Violence Court 13 Coordinated Response to Domestic Violence: Are they Effective? 15 Critiques of the Coordinated Community Response 17 Goals of the Domestic Violence Court 20 Victim Services and Safety 20 How Effective are Victim Services? 22 Offender Accountability 24 Strength and Limitations of Batterer Intervention Programs 26 Court Efficiency 27 The Importance of a Dedicated Staff and Informed Decision Making 28 The Role of Judges within the Domestic Violence Court 29 The Effects of Judicial Behavior on Petitioners and Respondents 30 Research Objectives 33 Chapter 2: Research Design 34 Study Settings 35 Basic Processes of both Domestic Violence Court Locations 35 Distinctions between the Courts 37 Development of the Domestic Violence Court 37 Victim Advocates and the Presence of Court Appointed Lawyers 39
Electron beam Ni-layer deposited LaTiO2N photoanodes for the enhanced photoelectrochemical performance of water oxidation

Improving the photoconversion efficiency of LaTiO2N photoanodes is crucial in the strong oxidizing conditions and in high overpotential of four-electron water oxidation system. It is essential for electrode to improve simultaneously reduce the recombination, photo/chemical corrosion resistivity and optical losses. In our present study, the photoelectrode has been fabricated by homogeneous CoOx co-catalyst aided by impregnation annealing method and coated with an ultrathin Ni layer by electron beam evaporation method (EB). The fabricated electrode was transferred to a three-electrode photoelectrochemical (PEC) cell system and electrodeposited of cobalt-phosphate (Co-Pi) loading as an oxygen evolution (OER) co-catalyst. The CoPi deposition was fixed and variable the Ni-coating and CoOx co-catalysts for optimization the best results of electrode. The optimal 2 nm Ni coating with 3wt% CoOx-co-catalyst loading on electrode, resulted in significantly enhanced the photocurrent and PEC water oxidation performance. The Ni and CoOx-modified LaTiO2N electrode serve as a highly active O2- evolving photoanode achieving 3.7 mA cm−2 of the photocurrent density at 1.23V versus reversible hydrogen electrode (Vrhe) in 0.2 M K2HPO4 solution (adjusted pH 13 by addition of NaOH) under solar simulator irradiation Airmass 1.5 Global (AM 1.5G). The current-voltage was optimized off all modified electrode and found the maximum solar to energy conversion efficiency is 0.61% with IPCE 35% at 480 nm wavelength at 1 Vrhe. The maximum amounts of evolved O2 and H2 were found 16 and 32 μmol for two hours at 1 Vrhe of optimal technique CoPi-Ni-modified CoOx-LaTiO2N electrode (CoPi/Ni/Co Ox/LaTiO2N/T a/Ti) respectively. The optical transparency of the ultrathin Ni coating establishing as a particularly advantageous treatment for efficient and stable water oxidation photoanodes.
Dual-Band Antenna Integrating With Rectangular Mushroom-Like Superstrate for WLAN Applications

A rectangular mushroom-like superstrate structure is proposed to design an antenna for dual-band wireless local area network (WLAN) applications. The proposed antenna consists of an array of mushroom-like rectangular patches and a planar slot antenna. Based on the dispersion diagram analysis, the proposed antenna can operate in two bands: The lower band is from 2.3 to 2.98 GHz, with -10-dB bandwidth of 25.8%, which is corresponding to zeroth-order resonant (ZOR) mode, and the upper band is from 5.02 to 5.84 GHz, with -10-dB bandwidth of 15.1% and average realized gain of 6.9 dB at boresight. The proposed antenna is feasible to cover the specification for dual-band WLAN applications in the 2.4-GHz (2400-2484 MHz) and 5-GHz (5150-5825 MHz) bands. Furthermore, the proposed antenna has a low profile of 4.2 mm and compact size of 33 ×30 mm2, which is suitable for installation in wireless handheld devices. The simulated and measured results are in good agreement to verify the good performance of the proposed antenna.
Hop by Hop congestion control system for adhoc networks

As the development of Internet continues, congestion control has become a major issue to the computer network society. Most of the congestion control schemes fall into two categories : end to end and hop-by-hop (HBH) congestion control schemes. The hop-by-hop algorithm can achieve short delays and quick responses to the congestion situations, and cause no packet loss. It can also minimize the bandwidth requirement and achieve high buffer usage level for nodes along the transmission path. In HBH mechanisms, traffic control is used at each node along the traffic flow path. As a consequence, congestion along the traffic flow path could be detected immediately and appropriate control could be carried out (e.g., buffering packets) at the immediate upstream node to avoid the congestion condition. In this paper the HBH congestion control scheme is implemented using network simulator and the simulation results are analyzed as to how effectively it sends feedback to its upstream nodes and also decreases the rate of sending accordingly.
CPW-Fed Inkjet Printed UWB Antenna on ABS-PC for Integration in Molded Interconnect Devices Technology

This letter highlights the potential of inkjet-printing on molded interconnect device technology for the realization of ultrawide band (UWB) antennas. Low-cost thermoplastic acrylonitrile butadiene styrene polycarbonate (ABS-PC) substrate is selected for its promising mechanical and thermal properties. First, electrical characterizations of bare ABS-PC are done using resonance cavity method and then the measurements of S-parameters of two 50 Ω-CPW transmission lines, allow the extraction of both relative permittivity and RF losses. Inkjet printing of silver nano ink is used to fabricate those CPW lines on the top of a 2-mm-thick ABS-PC. The measurements show a relative substrate permittivity equal to 2.8 with conductive and dielectric losses of 19.5 dB/m and 2.4 dB/m at 2 GHz, respectively. Then, an UWB antenna based on a half circular disc monopole and a rectangular patch with two steps is designed and realized by inkjet on ABS-PC. This printed antenna provides a good impedance matching over the entire bandwidth of 3 GHz-13 GHz. Radiation pattern is omnidirectionnal in both E and H planes until 5 GHz and is deformed at higher frequencies due to the higher order modes.
Changes in Microtubule Protofilament Number Induced by Taxol Binding to an Easily Accessible Site

We have investigated the accessibility of the Taxol-binding site and the effects of Taxol binding on the structures of assembled microtubules. Taxol and docetaxel readily bind to and dissociate from microtubules, reaching 95% ligand exchange equilibrium in less than 3 min under our solution conditions (microtubules were previously assembled from GTP-tubulin, GTP-tubulin and microtubule-associated proteins, or GDP-tubulin and taxoid). Microtubules assembled from purified tubulin with Taxol are known to have typically one protofilament less than with the analogue docetaxel and control microtubules. Surprisingly, Taxol binding and exchange induce changes in the structure of preformed microtubules in a relatively short time scale. Cryoelectron microscopy shows changes toward the protofilament number distribution characteristic of Taxol or docetaxel, with a half-time of ∼0.5 min, employing GDP-tubulin-taxoid microtubules. Correspondingly, synchrotron x-ray solution scattering shows a reduction in the mean microtubule diameter upon Taxol binding to microtubules assembled from GTP-tubulin in glycerol-containing buffer, with a structural relaxation half-time of ∼1 min. These results imply that microtubules can exchange protofilaments upon Taxol binding, due to internal dynamics along the microtubule wall. The simplest interpretation of the relatively fast taxoid exchange observed and labeling of cellular microtubules with fluorescent taxoids, is that the Taxol-binding site is at the outer microtubule surface. On the contrary, if Taxol binds at the microtubule lumen in agreement with the electron crystallographic structure of tubulin dimers, our results suggest that the inside of microtubules is easily accessible from the outer solution. Large pores or moving lattice defects in microtubules might facilitate the binding of taxoids, as well as of possible endogenous cellular ligands of the inner microtubule wall.
Obstacle avoidance for UAVs used in road accident monitoring

Roads accidents account for the highest percentage of fatalities in the world. These mortality rates are also increasing due to negligence and lack of proper care within sufficient time for the victims. The fact that the victim may be unnoticed or unreachable is majorly due to traffic blocks, adverse climatic conditions, improper terrain conditions etc. Unmanned Aerial Vehicles (UAVs) could be used to reduce the number of fatalities to an extent by giving immediate assistance and alerting the concerned authorities. The aim of the work in this paper is to develop approaches for avoidingthe obstacles in the path of UAVs such as trees, tall buildings, electric lines, mobile towers etc. for obtaining a collision free path for navigation. In this paper, sensor and image (fusion) based obstacle avoidance as a means for UAV to quickly and safely reach an accident site. We obtained a decision command by fusing an image with ultrasonic sensor data, which is used for controlling the UAV to avoid obstacles. We then compared the test results of the image-based obstacle avoidance method with the fusion-based obstacle avoidance, where we demonstrated that the decision commands used in fusion method are more accurate.
Changes in BAI1 and Nestin Expression Are Prognostic Indicators for Survival and Metastases in Breast Cancer and Provide Opportunities for Dual Targeted Therapies

The 2-year survival rate of patients with breast cancer brain metastases is less than 2%. Treatment options for breast cancer brain metastases are limited, and there is an unmet need to identify novel therapies for this disease. Brain angiogenesis inhibitor 1 (BAI1) is a GPCR involved in tumor angiogenesis, invasion, phagocytosis, and synaptogenesis. For the first time, we identify that BAI1 expression is significantly reduced in breast cancer and higher expression is associated with better patient survival. Nestin is an intermediate filament whose expression is upregulated in several cancers. We found that higher Nestin expression significantly correlated with breast cancer lung and brain metastases, suggesting both BAI1 and Nestin can be therapeutic targets for this disease. Here, we demonstrate the ability of an oncolytic virus, 34.5ENVE, to target and kill high Nestin-expressing cells and deliver Vstat120 (extracellular fragment of BAI1). Finally, we created two orthotopic immune-competent murine models of breast cancer brain metastases and demonstrated 34.5ENVE extended the survival of immune-competent mice bearing intracranial breast cancer tumors. Mol Cancer Ther; 14(1); 307–14. ©2014 AACR.
Practical issues in monitoring and reporting input and output power

Concerns about the consumption of energy by information technology (IT) equipment are driving a concerted effort to manage and reduce this power consumption. One of the most important metrics for energy management systems is the current power consumption. IT equipment power supplies are now generally required to report their input power with accuracy in the range of 2–5%. This paper describes some of the computational issues in monitoring and reporting equipment input power. It also describes a method for a power supply to report its input or output power without requiring the power supply to compute averages or have a real time clock.
Metabolomics in monitoring kidney transplants

Purpose of reviewThe success of any given kidney transplant is closely tied to the ability to monitor patients and responsively change their medications. Transplant monitoring is still, however, dependent on relatively old technologies: serum creatinine levels, urine output, blood pressure, blood glucose and histopathology of biopsy samples. These older technologies do not offer sufficient specificity, sensitivity, or accuracy to allow appropriate and timely interventions. Using the tools of genomics, proteomics and metabolomics new biomarkers are being found that may greatly improve transplant monitoring and significantly enhance graft survival. This review describes the basic principles of metabolomics and summarizes a number of recent developments in the use of metabolite biomarkers and metabolomics to monitor kidney transplants. Recent findingsChanges in the concentration profiles of a number of small molecule metabolites found in either blood or urine can be used to localize organ damage, identify organs at risk of rejection, assess organs suffering from ischemia–repurfusion injury or identify organs that have been damaged by immunosuppressive drugs. SummaryThe application of metabolomics to kidney transplant monitoring is still very much in its infancy. Nevertheless, there are a number of easily measured metabolites in both urine and serum that can provide reliable indications of organ function, organ injury, and immunosuppressive drug toxicity. As the field matures, metabolomics may eventually lead to the development of rapid, inexpensive and noninvasive approaches to assist clinicians in monitoring kidney transplants.
Enhanced Production of Nitric Oxide Leads to ATP Collapse in the Retinas of Otsuka Long-Evans Tokushima Fatty Rats, a Model of Human Diabetes

Abstract Purpose: We determined nitric oxide (NO) production via inducible NO synthase (iNOS) by hyperglycemia using the retina of Otsuka Long-Evans Tokushima Fatty rats (OLETF rats), and investigated the relationship between ATP contents and NO production in the retinas of OLETF rats. Methods: Long-Evans Tokushima Otsuka rats (LETO rats, normal rats) and OLETF rats (model rat for diabetes mellitus) aged 60 weeks of age were used. Plasma glucose (Glu) levels were determined using an Accutrend GCT System, and NO levels were measured by the microdialysis method as nitrite (). Cytochrome c oxidase (CCO) activity was measured using a Mitochondrial Isolation Kit and Cytochrome c Oxidase Assay Kit, and ATP levels were determined using a Sigma ATP Bioluminescent Assay Kit and a luminometer AB-2200. Results: levels in the retinas of OLETF rats were significantly higher than in LETO rats, and the levels in the retinas of 60-week-old OLETF rats increased with increasing Glu. CCO activity in the retinas of OLETF rats showed no significant difference from that in LETO rats; however, ATP levels in the retinas of OLETF rats were significantly lower than those in LETO rats. The oral administration of aminoguanidine or disulfiram, an iNOS inhibitor, attenuated the decrease in ATP levels in the retinas of 60-week-old OELTF rats. Conclusion: The present study demonstrates that NO production via iNOS in the retinas of 60-week-old OLETF rats is caused by hyperglycemia, and that NO causes a decrease in ATP contents in the retinas of 60-week-old OELTF rats. It is possible that the low ATP contents caused by NO may affect the normal functioning of the retina in OLETF rats.
Does anycast hang up on you?

Anycast-based services today are widely used commercially, with several major providers serving thousands of important websites. However, to our knowledge, there has been only limited study of how often anycast fails because routing changes interrupt connections between users and their current anycast site. While the commercial success of anycast CDNs means anycast usually works well, do some users end up shut out of anycast? In this paper we examine data from more than 9000 geographically distributed vantage points (VPs) to 11 anycast services to evaluate this question. Our contribution is the analysis of this data to provide the first quantification of this problem, and to explore where and why it occurs. We see that about 1% of VPs are anycast unstable, reaching a different anycast site frequently (sometimes every query). Flips back and forth between two sites in 10 seconds are observed in selected experiments for given service and VPs. Moreover, we show that anycast instability is persistent for some VPs — a few VPs never see a stable connections to certain anycast services during a week or even longer. The vast majority of VPs only saw unstable routing towards one or two services instead of instability with all services, suggesting the cause of the instability lies somewhere in the path to the anycast sites. Finally, we point out that for highly-unstable VPs, their probability to hit a given site is constant, which means the flipping are happening at a fine granularity — per packet level, suggesting load balancing might be the cause to anycast routing flipping. Our findings confirm the common wisdom that anycast almost always works well, but provide evidence that a small number of locations in the Internet where specific anycast services are never stable.
Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation

Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. However, the functional role of the ubiquitin system in neurogenesis is not known. Here we show that UCH-L1 regulates the morphology of neural progenitor cells (NPCs) and mediates neurogenesis. UCH-L1 was expressed in cultured NPCs as well as in embryonic brain. Its expression pattern in the ventricular zone (VZ) changed between embryonic day (E) 14 and E16, which corresponds to the transition from neurogenesis to gliogenesis. At E14, UCH-L1 was highly expressed in the ventricular zone, where neurogenesis actively occurs; whereas its expression was prominent in the cortical plate at E16. UCH-L1 was very weakly detected in the VZ at E16, which corresponds to the start of gliogenesis. In cultured proliferating NPCs, UCH-L1 was co-expressed with nestin, a marker of undifferentiated cells. In differentiating cells, UCH-L1 was highly co-expressed with the early neuronal marker TuJ1. Furthermore, when UCH-L1 was induced in nestin-positive progenitor cells, the number and length of cellular processes of the progenitors decreased, suggesting that the progenitor cells were differentiating. In addition, NPCs derived from gad (UCH-L1-deficient) mice had longer processes compared with controls. The ability of UCH-L1 to regulate the morphology of nestin-positive progenitors was dependent on its binding affinity for ubiquitin but not on hydrolase activity; this result was also confirmed using gad-mouse-derived NPCs. These results suggest that UCH-L1 spatially mediates and enhances neurogenesis in the embryonic brain by regulating progenitor cell morphology.