Miracle-dz/UniFAR-FTUs huggingface dataset:
Attachment Avoidance Is Significantly Related to Attentional Preference for Infant Faces: Evidence from Eye Movement Data

Objective: To determine the influence of adult attachment orientations on infant preference. Methods: We adopted eye-tracking technology to monitor childless college women’s eye movements when looking at pairs of faces, including one adult face (man or woman) and one infant face, with three different expressions (happy, sadness, and neutral). The participants (N = 150; 84% Han ethnicity) were aged 18–29 years (M = 19.22, SD = 1.72). A random intercepts multilevel linear regression analysis was used to assess the unique contribution of attachment avoidance, determined using the Experiences in Close Relationships scale, to preference for infant faces. Results: Women with higher attachment avoidance showed less infant preference, as shown by less sustained overt attentional bias to the infant face than the adult face based on fixation time and count. Conclusion: Adult attachment might be related to infant preference according to eye movement indices. Women with higher attachment avoidance may lack attentional preference for infant faces. The findings may aid the treatment and remediation of the interactions between children and mothers with insecure attachment.
The Protective Effects of Buzui on Acute Alcoholism in Mice

This study was designed to investigate the role of a traditional buzui recipe in anti-inebriation treatment. Buzui consists of Fructus Schisandrae Chinensis, Fructus Chebulae, Fructus Mume, Fructus Crataegi, Endothelium Corneum Gigeriae Galli, and Excrementum Bombycis. The buzui mixture was delivered by gavage, and ethanol was delivered subsequent to the final treatment. The effects of buzui on the righting reflex, inebriation rates, and the survival curve are depicted. Blood alcohol concentrations, alanine aminotransferase (ALT) levels, aspartate aminotransferase (AST) levels, and alkaline phosphatase (ALP) levels were recorded. The activities of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and superoxide dismutase (SOD), as well as malonaldehyde (MDA) levels, were also measured. Our results demonstrated that a traditional buzui recipe showed significant effects on promoting wakefulness and the prevention of acute alcohol intoxication, accelerating the metabolism of alcohol in the liver and reducing the oxidative damage caused by acute alcoholism.
MAGE-3 Protein in Lung Cancer Patients T Cell Responses to + Vaccine-Induced CD4

MAGE-3 is the most commonly expressed cancer testis Ag and thus represents a prime target for cancer vaccines, despite infrequent natural occurrence of MAGE-3-speciﬁc immune responses in vivo. We report in this study the successful induction of Ab, CD8 (cid:1) , and CD4 (cid:1) T cells in nonsmall cell lung cancer patients vaccinated with MAGE-3 recombinant protein. Two cohorts were analyzed: one receiving MAGE-3 protein alone, and one receiving MAGE-3 protein with adjuvant AS02B. Of nine patients in the ﬁrst cohort, three developed marginal Ab titers and another one had a CD8 (cid:1) T cell response to HLA-A2-restricted peptide MAGE-3 271–279. In contrast, of eight patients from the second cohort vaccinated with MAGE-3 protein and adjuvant, seven developed high-titered Abs to MAGE-3, and four had a strong concomitant CD4 (cid:1) T cell response to HLA-DP4-restricted peptide 243–258. One patient simultaneously developed CD8 (cid:1) T cells to HLA-A1-restricted peptide 168–176. The novel monitoring methodology used in this MAGE-3 study establishes that protein vaccination induces clear CD4 (cid:1) T cell responses that correlate with Ab production. This development provides the framework for further evaluating integrated immune responses in vaccine settings and for optimizing these responses for clinical beneﬁt. The Journal of Immunology, 2004, 172: 3289–3296. MAGE-3 Ag was identiﬁed during analysis of CD8 (cid:1) avoid potential reactivity with protein D, and found consistent results when cotyping re- activity against the MAGE-3 protein used for vaccination. MAGE-1 and NY-ESO-1 recombinant proteins were used as negative controls, to rule out reactivity against bacterial contaminants (7). Positive results were deﬁned from titration curves, as described before (7). In summary ﬁgures, to fa- cilitate comparison of Ab responses between patients, all sample OD values at 1/400 serum dilution were normalized according to positive and negative control sera using the following formula: (OD sample (cid:3) OD negative control )/(OD positive control (cid:3) OD negative control ). Positive control serum from patient A25 ranged from 1000 to 1900 absorbance units, and negative control serum from patient NW29 ranged from 100 to 300 absorbance units at 1/400 dilution.
From Region Encoding To Extended Dewey: On Efficient Processing of XML Twig Pattern Matching

Finding all the occurrences of a twig pattern in an XML database is a core operation for efficient evaluation of XML queries. A number of algorithms have been proposed to process a twig query based on region encoding labeling scheme. While region encoding supports efficient determination of structural relationship between two elements, we observe that the information within a single label is very limited. In this paper, we propose a new labeling scheme, called extended Dewey. This is a powerful labeling scheme, since from the label of an element alone, we can derive all the elements names along the path from the root to the element. Based on extended Dewey, we design a novel holistic twig join algorithm, called TJFast. Unlike all previous algorithms based on region encoding, to answer a twig query, TJFast only needs to access the labels of the leaf query nodes. Through this, not only do we reduce disk access, but we also support the efficient evaluation of queries with wildcards in branching nodes, which is very difficult to be answered by algorithms based on region encoding. Finally, we report our experimental results to show that our algorithms are superior to previous approaches in terms of the number of elements scanned, the size of intermediate results and query performance.
Crypsis via leg clustering: twig masquerading in a spider

The role of background matching in camouflage has been extensively studied. However, contour modification has received far less attention, especially in twig-mimicking species. Here, we studied this deceptive strategy by revealing a special masquerade tactic, in which the animals protract and cluster their legs linearly in the same axis with their bodies when resting, using the spider Ariamnes cylindrogaster as a model. We used cardboard papers to construct dummies resembling spiders in appearance and colour. To differentiate the most important factors in the concealment effect, we manipulated body size (long or short abdomen) and resting postures (leg clustered or spread) of the dummies and recorded the responses of predators to different dummy types in the field. The results showed that dummies with clustered legs received significantly less attention from predators, regardless of the body length. Thus, we conclude that A. cylindrogaster relies on the resting posture rather than body size for predator avoidance. This study provides, to the best of our knowledge, empirical evidence for the first time that twig-mimicking species can achieve effective camouflage by contour modification.
Analyzing national e-Government interoperability frameworks: A case of Thailand

Many countries have actively engaged in the development of interoperability for electronic data and transaction exchange among government agencies to provide better joint-up public services to their citizens. National-level policy frameworks, often called Electronic Government Interoperability Frameworks (e-GIF), were established in many of those countries. However, most of these e-GIF frameworks haven't adopted the holistic concept of Enterprise Architectures (EA), except for example, Thailand, U.S.A. and Canada. This paper proposes a comparative analysis methodology with an aim to propose further improvement for the EA-based interoperability frameworks to better drive the effective development of smart and connected e-government services. In this paper, Thailand e-Government Interoperability Framework is methodically compared and analyzed with the U.S. Federal Enterprise Architecture Framework as a case study.
Endothelial Progenitor Cells Induce a Phenotype Shift in Differentiated Endothelial Cells towards PDGF/PDGFRβ Axis-Mediated Angiogenesis

Background Endothelial Progenitor Cells (EPC) support neovascularization and regeneration of injured endothelium both by providing a proliferative cell pool capable of differentiation into mature vascular endothelial cells and by secretion of angiogenic growth factors. Objective The aim of this study was to investigate the role of PDGF-BB and PDGFRβ in EPC-mediated angiogenesis of differentiated endothelial cells. Methods and Results Conditioned medium from human EPC (EPC-CM) cultured in hypoxic conditions contained substantially higher levels of PDGF-BB as compared to normoxic conditions (P<0.01). EPC-CM increased proliferation (1.39-fold; P<0.001) and migration (2.13-fold; P<0.001) of isolated human umbilical vein endothelial cells (HUVEC), as well as sprouting of vascular structures from ex vivo cultured aortic rings (2.78-fold increase; P = 0.01). The capacity of EPC-CM to modulate the PDGFRβ expression in HUVEC was assessed by western blot and RT-PCR. All the pro-angiogenic effects of EPC-CM on HUVEC could be partially inhibited by inactivation of PDGFRβ (P<0.01). EPC-CM triggered a distinct up-regulation of PDGFRβ (2.5±0.5; P<0.05) and its phosphorylation (3.6±0.6; P<0.05) in HUVEC. This was not observed after exposure of HUVEC to recombinant human PDGF-BB alone. Conclusion These data indicate that EPC-CM sensitize endothelial cells and induce a pro-angiogenic phenotype including the up-regulation of PDGFRβ, thereby turning the PDGF/PDGFRβ signaling-axis into a critical element of EPC-induced endothelial angiogenesis. This finding may be utilized to enhance EPC-based therapy of ischemic tissue in future.
Chemical Constituents and Anticancer Effects of the Essential Oil from Leaves of Xylopia laevigata

Abstract Xylopia laevigata, popularly known as “meiú” and “pindaíba”, is a medicinal plant used in the folk medicine of the Brazilian Northeast for several purposes. The chemical constituents of the essential oil from leaves of X. laevigata, collected from wild plants growing at three different sites of the remaining Atlantic forest in Sergipe State (Brazilian Northeast), were analyzed by GC/FID and GC/MS. The effect of the essential oil samples was assessed on tumor cells in culture, as well on tumor growth in vivo. All samples of the essential oil were dominated by sesquiterpene constituents. A total of 44 compounds were identified and quantified. Although some small differences were observed in the chemical composition, the presence of γ-muurolene (0.60–17.99 %), δ-cadinene (1.15–13.45 %), germacrene B (3.22–7.31 %), α-copaene (3.33–5.98 %), germacrene D (9.09–60.44 %), bicyclogermacrene (7.00–14.63 %), and (E)-caryophyllene (5.43–7.98 %) were verified as major constituents in all samples of the essential oil. In the in vitro cytotoxic study, the essential oil displayed cytotoxicity to all tumor cell lines tested, with the different samples displaying a similar profile; however, they were not hemolytic or genotoxic. In the in vivo antitumor study, tumor growth inhibition rates were 37.3–42.5 %. The treatment with the essential oil did not significantly affect body weight, macroscopy of the organs, or blood leukocyte counts. In conclusion, the essential oil from the leaves of X. laevigata is chemically characterized by the presence of γ-muurolene, δ-cadinene, germacrene B, α-copaene, germacrene D, bicyclogermacrene, and (E)-caryophyllene as major constituents and possesses significant in vitro and in vivo anticancer potential.
Transmission of the nocturnal periodic strain of Wuchereria bancrofti by Culex quinquefasciatus: establishing the potential for urban filariasis in Thailand

Control programmes have reduced the prevalence of Bancroftian filariasis in Thailand to low levels. Recently, there has been an influx of more than one million Myanmar immigrants into urban centres of Thailand. The prevalence of patent Wuchereria bancrofti infection in these immigrants (2–5%) has prompted concern in the public health community that the potential now exists for a re-emergence of Bancroftian filariasis in Thailand. It is possible that an urban cycle of transmission could become established. The Myanmar immigrants are infected with the nocturnal periodic (urban) type W. bancrofti for which Culex quinquefasciatus serves as the main vector. The Thai strains of Cx. quinquefasciatus have never been reported to transmit Bancroftian filariasis. Our results of feeding experiments demonstrated that the Thai Cx. quinquefasciatus are permissive for the development of Myanmar W. bancrofti to infective third-stage larvae thus establishing the potential for establishing an urban cycle of transmission in Thailand. We also adapted the SspI repeat PCR assay for the identification of infective mosquitoes that was capable of detecting a single infective stage larvae in a pool of 100 mosquitoes.
Design of Slotted Ground Hexagonal Microstrip Patch Antenna and Gain Improvement with FSS Screen

Three hexagonal patch antennas are designed for circular polarization and experimentally validated. These antennas are labeled; simple hexagonal patch, hexagonal patch with slotted ground and hexagonal patch with parasitic element. The measured impedance bandwidths of the three antennas are 2% for the simple patch, 5.2% for the patch with slotted ground and 6.35% for the antenna with parasitic element. The axial ratio (measured) obtained is 4.73% for the patch with slotted ground and 3.33% for the hexagonal patch antenna with parasitic element. The measured radiation patterns of these antennas are found to be in good agreement with the simulated radiation patterns. The average gain of all the three antennas is also evaluated. A frequency selective surface (FSS) is proposed with dimensions smaller than that of a conventional FSS structure. The measured gain improvement with the proposed FSS is around 3dB in the operating band.
Distributed Non-Convex ADMM-inference in Large-scale Random Fields

We propose a parallel and distributed algorithm for solving discrete labeling problems in large scale random fields. Our approach is motivated by the following observations: i) very large scale image and video processing problems, such as labeling dozens of million pixels with thousands of labels, are routinely faced in many application domains; ii) the computational complexity of the current state-of-the-art inference algorithms makes them impractical to solve such large scale problems; iii) modern parallel and distributed systems provide high computation power at low cost. At the core of our algorithm is a tree-based decomposition of the original optimization problem which is solved using a non convex form of the method of alternating direction method of multipliers (ADMM). This allows efficient parallel solving of resulting sub-problems. We evaluate the efficiency and accuracy offered by our algorithm on several benchmark lowlevel vision problems, on both CPU and Nvidia GPU. We consistently achieve a factor of speed-up compared to dual decomposition (DD) approach and other ADMM-based approaches.
Validating and evolving software requirements in a systematic framework

The concern is with validation and evolution of software requirements based on the notion of executable specifications. A fundamental premise of this approach is that it is possible to use executable specification descriptions and conventional implementation descriptions interchangeably. This allows a prototype system to be transformed into a production quality system by incrementally replacing specifications with implementations which conform to them. <<ETX>>
Étude des mesures de similarité sémantique basées sur les arcs

RESUME. Les mesures de similarite semantique sont des fonctions tres utilisees dans plusieurs domaines de l’informatique parmi lesquels nous pouvons citer le Traitement Automatique du Langage Naturel (TALN), la Bioinformatique, la Recherche d’Information. Elles permettent de determiner la similarite entre des termes ou concepts qui n’ont aucune ressemblance syntaxique. L’objectif de ce papier est de faire une etude d’une classe particuliere de mesures de similarite semantique : les mesures basees sur les arcs. Nous ferons, dans cet article, un etat de l’art de ces mesures qui aboutira a des simulations de ces dernieres a l’aide d’une base de connaissances commune afin de les comparer et d’evaluer leurs performances.
An image guided small animal stereotactic radiotherapy system

Small animal radiotherapy studies should be performed preferably on irradiators capable of focal tumor irradiation and healthy tissue sparing. In this study, an image guided small animal arc radiation treatment system (iSMAART) was developed which can achieve highly precise radiation targeting through the utilization of onboard cone beam computed tomography (CBCT) guidance. The iSMAART employs a unique imaging and radiation geometry where animals are positioned upright. It consists of a stationary x-ray tube, a stationary flat panel detector, and a rotatable and translational animal stage. System performance was evaluated in regards to imaging, image guidance, animal positioning, and radiation targeting using phantoms and tumor bearing animals. The onboard CBCT achieved good signal, contrast, and sub-millimeter spatial resolution. The iodine contrast CBCT accurately delineated orthotopic prostate tumors. Animal positioning was evaluated with ∼0.3 mm vertical displacement along superior-inferior direction. The overall targeting precision was within 0.4 mm. Stereotactic radiation beams conformal to tumor targets can be precisely delivered from multiple angles surrounding the animal. The iSMAART allows radiobiology labs to utilize an image guided precision radiation technique that can focally irradiate tumors while sparing healthy tissues at an affordable cost.
DAML-S: Semantic Markup for Web Services

The Semantic Web should enable greater access not only to content but also to services on the Web. Users and software agents should be able to discover, invoke, compose, and monitor Web resources offering particular services and having particular properties. As part of the DARPA Agent Markup Language program, we have begun to develop an ontology of services, called DAML-S, that will make these functionalities possible. In this paper we describe the overall structure of the ontology, the service profile for advertising services, and the process model for the detailed description of the operation of services. We also compare DAML-S with several industry efforts to define standards for characterizing services on the Web.
RNAdb—a comprehensive mammalian noncoding RNA database

In recent years, there have been increasing numbers of transcripts identified that do not encode proteins, many of which are developmentally regulated and appear to have regulatory functions. Here, we describe the construction of a comprehensive mammalian noncoding RNA database (RNAdb) which contains over 800 unique experimentally studied non-coding RNAs (ncRNAs), including many associated with diseases and/or developmental processes. The database is available at http://research.imb. uq.edu. au/RNAdb and is searchable by many criteria. It includes microRNAs and snoRNAs, but not infrastructural RNAs, such as rRNAs and tRNAs, which are catalogued elsewhere. The database also includes over 1100 putative antisense ncRNAs and almost 20 000 putative ncRNAs identified in high-quality murine and human cDNA libraries, with more to be added in the near future. Many of these RNAs are large, and many are spliced, some alternatively. The database will be useful as a foundation for the emerging field of RNomics and the characterization of the roles of ncRNAs in mammalian gene expression and regulation.
Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana

Significance Plant development depends on the Polycomb Group (PcG) pathway, which ensures an epigenetic memory of gene repression. PcG proteins form complexes that decorate histones of target genes with signature modifications. Decorated histones are diluted during DNA replication, therefore compensatory mechanisms must ensure their renewal during cell division. We show that a protein related to a yeast replication factor plays an important role in maintaining a PcG-associated chromatin modification in dividing plant cells. Polycomb Repressive Complex (PRC) 2 catalyzes the H3K27me3 modification that warrants inheritance of a repressive chromatin structure during cell division, thereby assuring stable target gene repression in differentiated cells. It is still under investigation how H3K27me3 is passed on from maternal to filial strands during DNA replication; however, cell division can reinforce H3K27me3 coverage at target regions. To identify novel factors involved in the Polycomb pathway in plants, we performed a forward genetic screen for enhancers of the like heterochromatin protein 1 (lhp1) mutant, which shows relatively mild phenotypic alterations compared with other plant PRC mutants. We mapped enhancer of lhp1 (eol) 1 to a gene related to yeast Chromosome transmission fidelity 4 (Ctf4) based on phylogenetic analysis, structural similarities, physical interaction with the CMG helicase component SLD5, and an expression pattern confined to actively dividing cells. A combination of eol1 with the curly leaf (clf) allele, carrying a mutation in the catalytic core of PRC2, strongly enhanced the clf phenotype; furthermore, H3K27me3 coverage at target genes was strongly reduced in eol1 clf double mutants compared with clf single mutants. EOL1 physically interacted with CLF, its partially redundant paralog SWINGER (SWN), and LHP1. We propose that EOL1 interacts with LHP1–PRC2 complexes during replication and thereby participates in maintaining the H3K27me3 mark at target genes.
Classic and molecular cytogenetic analyses reveal chromosomal gains and losses correlated with survival in head and neck cancer patients.

PURPOSE Genetic biomarkers of head and neck tumors could be useful for distinguishing among patients with similar clinical and histopathologic characteristics but having differential probabilities of survival. The purpose of this study was to investigate chromosomal alterations in head and neck carcinomas and to correlate the results with clinical and epidemiologic variables. EXPERIMENTAL DESIGN Cytogenetic analysis of short-term cultures from 64 primary untreated head and neck squamous cell carcinomas was used to determine the overall pattern of chromosome aberrations. A representative subset of tumors was analyzed in detail by spectral karyotyping and/or confirmatory fluorescence in situ hybridization analysis. RESULTS Recurrent losses of chromosomes Y (26 cases) and 19 (14 cases), and gains of chromosomes 22 (23 cases), 8 and 20 (11 cases each) were observed. The most frequent structural aberration was del(22)(q13.1) followed by rearrangements involving 6q and 12p. The presence of specific cytogenetic aberrations was found to correlate significantly with an unfavorable outcome. There was a significant association between survival and gains in chromosomes 10 (P = 0.008) and 20 (P = 0.002) and losses of chromosomes 15 (P = 0.005) and 22 (P = 0.021). Univariate analysis indicated that acquisition of monosomy 17 was a significant (P = 0.0012) factor for patients with a previous family history of cancer. CONCLUSIONS The significant associations found in this study emphasize that alterations of distinct regions of the genome may be genetic biomarkers for a poor prognosis. Losses of chromosomes 17 and 22 can be associated with a family history of cancer.