Miracle-dz/UniFAR-FTUs huggingface dataset:
Mixed chimaerism is common at the time of acute graft‐versus‐host disease and disease response in patients receiving non‐myeloablative conditioning and allogeneic stem cell transplantation

We report the clinical outcome and results of chimaerism analysis in various cell lineages of 30 patients given non‐myeloablative conditioning, followed by allogeneic stem cell transplantation (SCT). The commonest diagnoses were chronic myelogenous leukaemia (n = 11) and solid tumours (n = 11). Twenty‐one patients received SCT from human leucocyte antigen (HLA)‐identical siblings and nine from matched unrelated donors. Median patient age was 53 (28–77) years. Four non‐myeloablative protocols were used, including fludarabine (30 mg/m2 × 3–6), busulphan (4 mg/kg × 2), cyclophosphamide (Cy) (30 mg/kg/day × 2) or total body irradiation (2 Gy), and anti‐thymocyte globulin. The patients were analysed by polymerase chain reaction (PCR) analysis of minisatellites on days 14, 21 and 28, then every other week up to 3 months and monthly thereafter. All samples were cell separated for T, B and myeloid cells using immunomagnetic beads. Eighteen patients were alive at a median follow‐up of 11 (6–20) months. Acute graft‐versus‐host disease (GVHD) occurred in 22 patients. Eighteen of the 22 patients with acute GVHD showed mixed chimaerism (MC) in the T‐cell fraction at the time of acute GVHD. However, all patients with acute GVHD showed donor chimaerism (DC) in the T‐cell fraction median 76 (7–414) days after onset versus three out of eight patients without acute GVHD, P < 0·001]. Disease response was diagnosed in 15 patients, median 100 (37–531) days after SCT. At the time of disease response, six out of15 patients showed MC in the T‐cell fraction. In conclusion, mixed chimaerism in the T‐cell fraction is common at the time of acute GVHD and disease response in patients conditioned with non‐myeloablative therapy.
The indirect effect of evaluative conditioning on smoking

Abstract Dual-process theories can account for the difficulties smokers encounter in their attempt to cease or at least to decrease their smoking consumption. The aim of this study was to test the indirect effect of an evaluative conditioning intervention on reducing the smoking behavior through the serial mediation of implicit and explicit attitudes. Fifty-five smoking addicted students were randomly assigned in two experimental conditions: positively versus negatively conditioned towards smoking related stimuli. The results support the indirect effect. The intervention affects implicit attitudes towards smoking, this leads to changes in explicit attitudes, which finally affects the self-reported smoking behavior in the expected direction (e.g. negative conditioning decreases self-reported smoking consumption).
Managing change through management development: an industry case study

Purpose – The purpose of this paper is to explore the interconnections between management development and change management within the context of an industry case study. To develop strategies for how management development practices might better support the management of change.Design/methodology/approach – Using a constructivist methodology, one‐to‐one interviews were conducted with two groups: a randomly chosen cross‐section of middle managers and a purposive sample of senior stakeholders within the industry. Thematic analysis was used to interpret the interview data.Findings – The study finds that there was not a clear understanding of how the management of change fitted within the overall job role of the middle managers. How middle managers actually manage change on a day‐to‐day basis has been largely ignored or taken for granted. This has led to considerable stress on managers. There is a wide range of management development practices in the industry, with many managers receiving low levels of prepar.
Nerve fibers in culture and their interactions with non-neural cells visualized by immunofluorescence

Cultures of embryonic mouse spinal cord explants, alone or in combination with rat myotubes, were stained by indirect immunofluorescence using antibodies against three structural proteins to: (a) reveal the distribution of these proteins among different cell types, and (b) test the usefulness of antibody staining to reveal the gross morphology of the neurite network in complex cultures. Affinity column purified antibodies were used against chicken gizzard actin, porcine brain tubulin, and skeletal muscle alpha-actinin. Neurites were stained intensely by anti-actin as was the stress fiber pattern of underlying fibroblasts. With anti-tubulin, the staining of neurites was an order of magnitude more intense than the staining of the microtubule pattern of background fibroblasts. Neurite cell bodies and astrocyte- like glia cells were stained with anti-tubulin and their nuclei remained unstained. Anti-tubulin could thus be used to trace even the finest extensions of nerve processes in spinal cord and spinal cord- muscle cultures. Furthermore, it could be combined with the histochemical reaction for acetylcholinesterase (AChE, EC 3.1.1.7) to demonstrate AChE-positive neurons and specialized nerve-muscle contact sites. The staining of neural elements with anti-alpha-actinin was generally much weaker than with anti-actin and anti-tubulin. Neurites were stained only moderately in comparison to myotube Z lines in the same culture. However, a distinct staining of the periphery of dorsal root ganglion cells was observed. Thus, a protein immunologically related to muscle alpha-actinin is present in the nervous system. In myotubes, Z lines were stained intensely with anti-alpha-actinin while I bands were only faintly stained with anti-actin. In isolated myofibrils, both structures were stained intensely with the same antibody preparations.
Plasma miR-155, miR-203, and miR-205 are Biomarkers for Monitoring of Primary Cutaneous T-Cell Lymphomas

Primary cutaneous T-cell lymphomas (CTCL) affect the skin and tend to transform and spread. CTCL involves primarily the Mycosis fungoides (MF) and more aggressive Sezary syndrome (SS). Oncogenic microRNAs (miRs) are stable epigenetic inhibitors often deregulated in the tumour and detectable as biomarkers in non-cellular fractions of peripheral blood. The tumour-specific expression of miR-155, miR-203, and miR-205 was shown to correctly diagnose CTCL. We herein asked whether these microRNAs can be used as plasma biomarkers for clinical CTCL monitoring. Patients with CTCL (n = 10) and controls with non-malignant conditions (n = 11) repeatedly donated plasma samples every ca. five months. MicroRNAs were detected in the plasma samples by specifically-primed RT-PCR followed by multivariate analyses of the miR expression dynamics. We herein established the plasma miR-classifier for detecting CTCL based on the miR-155 upregulation and miR-203/miR-205 downregulation with 100% specificity and 94% sensitivity. The 3-miR-score in the consecutive samples coincided with the clinical outcome of MF and SS patients such as the therapy response or changes in the clinical stage or tumor size. Quantitation of the selected microRNAs in plasma is a specific and straightforward approach for evaluating CTCL outcome representing, thus, a valuable tool for CTCL diagnostics and therapy response monitoring.
The development of a forensic clinical psychology service in a community mental health team

Abstract This study provides detailed psychometric data on the patients in the care of a community forensic team in south-east London. Out of 59 patients referred to the psychology service, 39 (66%) attended at least one appointment. Overall, about 42% of all psychology appointments offered were not attended. The great majority (93%) of the patients were male, typically with a history of major mental illness and an index offence of either violence or sexual assault. The results from the psychometric testing confirmed that most of the patients have serious mental illness problems, which are often combined with marked antisocial personality traits, criminality proneness, and low self-esteem. Taken together, these findings suggest that many of the patients have a variety of complex psychiatric and psychological problems, which require intense intervention by a specialist team.
Part-Based Multi-Frame Registration for Estimation of the Growth Of Cellular Networks in Plant Roots

Motion estimation from confocal scanning laser microscope images of growing plant cell structures presents interesting challenges; motion exhibits multiple local discontinuities and noise is non-isotropic and non-Gaussian. A method is presented for estimating motion of cell networks based on a physically motivated, part-based model of cell boundary structure. Each part models the shape and appearance of a localised image region and can undergo constrained non-rigid deformation. This enables motion discontinuities between parts to be modelled. Parts are coupled in order to improve localisation and increase computational efficiency. Results from applying MCMC show accurate localisation of the structure across multiple frames. The form of the model assists biologists in interpreting growth
Craniofacial Morphology in Myostatin-deficient Mice

GDF-8 (myostatin) is a negative growth regulator of skeletal muscle, and myostatin-deficient mice are hypermuscular. Muscle size and force production are thought to influence growth of the craniofacial skeleton. To test this relationship, we compared masticatory muscle size and craniofacial dimensions in myostatin-deficient and wild-type CD-1 control mice. Myostatin-deficient mice had significantly (p < 0.01) greater body (by 18%) and masseter muscle weight (by 83%), compared with wild-type controls. Significant differences (p < 0.05) were noted for cranial vault length, maxillary length, mandibular body length, and mandibular shape index. Significant correlations were noted between masseter muscle weight and mandibular body length (r = 0.68; p < 0.01), cranial vault length (r = −0.57; p < 0.05), and the mandibular shape index (r = −0.56; p < 0.05). Masticatory hypermuscularity resulted in significantly altered craniofacial morphology, probably through altered biomechanical stress. These findings emphasize the important role that masticatory muscle function plays in the ontogeny of the cranial vault, the maxilla, and, most notably, the mandible.
A critical review of interventionist research

Purpose - The purpose of this paper is to further develop the epistemological base of interventionist research (IR) as a valid accounting and management research methodology, through the identification of intervention theory and an IR framework derived from social sciences. Moreover, this paper seeks to contribute to empirical knowledge of IR through a critical review of limited empirical evidence relating to intervention theory and the extant IR frameworks derived from action research. Design/methodology/approach - Texts and academic journal papers that judiciously review intervention theory, intervention research frameworks were identified systematically; along with empirical research addressing theoretical and methodological deficiencies of IR and, providing evidence to inform practical considerations when undertaking IR. Findings - The key findings include rare empirical evidence addressing theoretical shortcomings and application of intervention theory, an IR framework derived from social sciences with extremely limited use in accounting and management research, deficiencies in action research oriented frameworks labelled as alternative forms of IR, an alternate perspective to positivistic validity and reliability issues and other practical considerations to facilitate the conducting of IR. Originality/value - The novelty of this paper lies in the diminution of the fragmented nature of IR that undermines its scientific value through the identification of an intervention theory and IR framework experiencing extremely limited use in accounting and management research, with the exception of a cross-disciplinary (management accounting and information systems) doctoral study, optimising IR utilisation with greater degrees of validity and reliability and, finally, a proposed alternative research design for utilisation in IR.
The Forecast of Carbonation Depth of Concrete Based on RBF Neural Network

By analyzing the causes and influencing factors of carbonation of concrete, the RBF neural network model for predicting carbonation depth of concrete is founded. And actual data is analyzed through an example and results are compared with the BP network model. The testing results show that RBF network model for predicting carbonation depth of concrete can become a new effective assessment model with better prediction results and higher recognition precision.
Phenotypic Plasticity in Drosophila Pigmentation Caused by Temperature Sensitivity of a Chromatin Regulator Network

Phenotypic plasticity is the ability of a genotype to produce contrasting phenotypes in different environments. Although many examples have been described, the responsible mechanisms are poorly understood. In particular, it is not clear how phenotypic plasticity is related to buffering, the maintenance of a constant phenotype against genetic or environmental variation. We investigate here the genetic basis of a particularly well described plastic phenotype: the abdominal pigmentation in female Drosophila melanogaster. Cold temperature induces a dark pigmentation, in particular in posterior segments, while higher temperature has the opposite effect. We show that the homeotic gene Abdominal-B (Abd-B) has a major role in the plasticity of pigmentation in the abdomen. Abd-B plays opposite roles on melanin production through the regulation of several pigmentation enzymes. This makes the control of pigmentation very unstable in the posterior abdomen, and we show that the relative spatio-temporal expression of limiting pigmentation enzymes in this region of the body is thermosensitive. Temperature acts on melanin production by modulating a chromatin regulator network, interacting genetically with the transcription factor bric-à-brac (bab), a target of Abd-B and Hsp83, encoding the chaperone Hsp90. Genetic disruption of this chromatin regulator network increases the effect of temperature and the instability of the pigmentation pattern in the posterior abdomen. Colocalizations on polytene chromosomes suggest that BAB and these chromatin regulators cooperate in the regulation of many targets, including several pigmentation enzymes. We show that they are also involved in sex comb development in males and that genetic destabilization of this network is also strongly modulated by temperature for this phenotype. Thus, we propose that phenotypic plasticity of pigmentation is a side effect reflecting a global impact of temperature on epigenetic mechanisms. Furthermore, the thermosensitivity of this network may be related to the high evolvability of several secondary sexual characters in the genus Drosophila.
The Thromboelastograph and the Thromboelastograph Technique

The thromboelastograph was originally described in 1948 by Hartert. I Work by Hartert and others in the 1950s evaluated the effect of clotting factor deficiencies, anticoagulants, thrombocytopenia, and fibrinolysis on the thromboelastograph and demonstrated that it could be used as a rapid empirical screen of overall hemostatic function. 2 The thromboelastograph has been used extensively in Europe for a number of years. Its availability was limited in the United States until the 1980s, when it underwent somewhat of a rebirth with its use during liver transplantation procedures. ,4 The blood clot has both viscous and elastic properties. The thromboelastograph measures the elastic shear modulus or storage modulus of clotting blood. As originally described by Hartert, it is independent of sample viscosity over a wide range.s Figure 1 shows a diagram of the sample mechanism of the thromboelastograph and a typical thromboelastograph tracing. Whole blood is placed in the sample cup. A pin suspended by a calibrated torsion wire is lowered into the sample. To measure the elastic shear modulus of the sample, the cup is oscillated through an angle of 4° 45' over a 10-second interval, including 1 second rest periods at the end of the rotation in each direction to prevent viscosity errors. The torque of the cup is transmitted to the pin through the sample in the cup. The width of the tracing is proportional to the magnitude of elastic shear modulus of the sample. Liquid whole blood transmits little or no torque from cup to pin, producing no deflection on the tracing even when the whole blood viscosity is high (such as in polycythemia or macroglobulinemia). As the blood clots, fibers composed of platelets and fibrin form between the cup and pin, transmitting a portion of the cup's motion to the
Transcranial Magnetic Stimulation in the Management of Mood Disorders

Background: Many trials of transcranial magnetic stimulation (TMS) have used small samples and, therefore, lack power. Here we present an up-to-date meta-analysis of TMS in the treatment of depression. Methods: We searched Medline and Embase from 1996 until 2008 for randomized sham-controlled trials, with patients and investigators blinded to treatment, and outcome measured using a version of the Hamilton Depression Rating Scale (or similar). We identified 1,789 studies. Thirty-one were suitable for inclusion, with a cumulative sample of 815 active and 716 sham TMS courses. Results: We found a moderately sized effect in favour of TMS [Random Effects Model Hedges’ g = 0.64, 95% confidence interval (95% CI) = 0.50–0.79]. The corresponding Pooled Peto Odds Ratio for treatment response (≤50% reduction in depression scores) was 4.1 (95% CI = 2.9–5.9). There was significant variability between study effect sizes. Meta-regressions with relevant study variables did not reveal any predictors of treatment efficacy. Nine studies included follow-up data with an average follow-up time of 4.3 weeks; there was no mean change in depression severity between the end of treatment and follow-up (Hedges’ g = –0.02, 95% CI = –0.22 to +0.18) and no heterogeneity in outcome. Discussion: TMS appears to be an effective treatment; however, at 4 weeks’ follow-up after TMS, there had been no further change in depression severity. Problems with finding a suitably blind and ineffective placebo condition may have confounded the published effect sizes. If the TMS effect is specific, only further large double-blind randomized controlled designs with systematic exploration of treatment and patient parameters will help to define optimum treatment indications and regimen.
Automatic discovery of global and local equivalence relationships in labeled geo-spatial data

We propose a novel algorithmic framework to automatically detect which labels refer to the same concept in labeled spatial data. People often use different words and synonyms when referring to the same concept or location. Furthermore these words and their usage vary across culture, language, and place. Our method analyzes the patterns in the spatial distribution of labels to discover equivalence relationships. We evaluate our proposed technique on a large collection of geo-referenced Flickr photos using a semi-automatically constructed ground truth from an existing ontology. Our approach is able to classify equivalent tags with a high accuracy (AUC of 0.85), as well as providing the geographic extent where the relationship holds.
PLEASE CITE THIS: An Exploratory Paper on Citations, Impacts and the Social Accounting Literature

This paper seeks to use the increasingly influential citation and impact data to explore the contours of the social and environmental accounting (SEA) literature. Our ambitions are fourfold. First, we offer a more nuanced understanding of the journals in which we tend to publish SEA research. Second, we tease out what might plausibly be thought to be one indication of the ‘most influential’ SEA papers. Third, we offer a substantive cautionary note about the dangers of the careless use of citations as singular measures of ‘quality’ or ‘importance’, etc. Finally, we place the growing SEA literature in a wider context which both flatters and challenges the community that SEAJ seeks to serve.
Towards a corpus-based dictionary of German noun-verb collocations

We 1 describe our attempts to automatically extract raw material for a dictionary of German noun-verb collo­ cations from large corpora of newspaper text. Such a dictionary should be about collocations and it should include a description of their linguistic properties, rather than listing the mere lexical cooccurrence. Since most statistical collocation finding tools do not provide other than lexical cooccurrence information, we first use symbolic extraction tools, based on a regular grammar over part-of-speech tagged and lemmatized text, and we use statistical filters thereafter. We first list the types of information which should be contained in a collocational dictionary for Natural Language Processing, then sketch our extraction methods and finally discuss and illustrate our initial results.
Induction of Diabetes‐Related Autoantibodies below Cutoff for “Positivity” in Young Nondiabetic Children

Abstract: The aim was to study the natural course of diabetes‐related autoantibodies at low concentrations, below “positivity”, in a nondiabetic population followed up from infancy. Blood samples were taken from 205 children at 6 weeks, 6 months, 18 months, and 5 years of age. Autoantibodies against GAD65 (GADA), tyrosine phosphatase (IA‐2A), and insulin (IAA) were determined by radioligand‐binding assays. All children had detectable levels of GADA and approximately half had IA‐2A, but only approximately 10% had detectable levels of IAA during the follow‐up period. Many children developed IA‐2A already at 6 months of age, similar concentrations were seen at 18 months, and then the levels of IA‐2A decreased until 5 years of age. GADA were induced less often at 6 months of age, increased up to 18 months, and fluctuated at similar levels up to 5 years of age. IAA were detectable in so few children and at low levels, so no trend in natural course could be revealed. We conclude that there is a natural induction of humoral immune response to β cell autoantigens early in life. Our results suggest that the mechanisms of β cell tolerance to GAD and IA‐2 differ in healthy children.
Ear recognition using LLE and IDLLE algorithm

Although ear recognition has been researched widely, there still exist some problems to be resolved in depth such as multi-pose ear recognition which is rarely focused on. In this paper, different from previous methods used for ear recognition, one nonlinear algorithm, called locally linear embedding (LLE) belonging to manifold learning technique is introduced, and an improved locally linear embedding algorithm (IDLLE) is proposed considering the disadvantage of the standard LLE algorithm. Comparison to PCA and KPCA, experimental results demonstrate that applying LLE for multi-pose ear recognition can obtain better recognition results; and using the IDLLE can further improve the recognition performance as for multi-pose ear recognition, which greatly shows the validity of this improved algorithm.