Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy and safety of certolizumab pegol without methotrexate co-administration in Japanese patients with active rheumatoid arthritis: The HIKARI randomized, placebo-controlled trial

Abstract Objective. This 24-week, placebo-controlled, double-blind, randomized study (NCT00791921) investigated efficacy and safety of certolizumab pegol (CZP) in Japanese rheumatoid arthritis (RA) patients in whom methotrexate (MTX) cannot be administered. Methods. A total of 230 patients were randomized to subcutaneous CZP 200 mg (induction dosing: 400 mg at Weeks 0, 2 and 4) or placebo every 2 weeks. Results. ACR20 responses with CZP were rapid and significant versus placebo at Week 1, sustained to Week 12 (67.2% vs. 14.9%) and Week 24 (63.8% vs. 11.4%). Week 24-modified Total Sharp Score (mTSS) change from baseline (CFB) was 0.48 (CZP) versus 2.45 (placebo). CZP treatment was associated with higher Week 12 ACR20 responses versus placebo (with non-MTX disease modifying antirheumatic drugs [DMARDs], 74.2% vs. 20.0%; without [monotherapy], 59.3% vs. 8.2%) and inhibition of radiographic progression at Week 24 (mTSS CFB; with non-MTX DMARDs, 0.24 vs. 1.61; monotherapy, 0.68 vs. 3.65). Incidences of serious adverse events were 11.2% (CZP) and 2.6% (placebo); one CZP patient died of dissecting aortic aneurysm. Conclusion. CZP treatment with and without non-MTX DMARDs in Japanese patients in whom MTX cannot be administered resulted in rapid, sustained reductions in RA signs and symptoms. Notably, CZP monotherapy showed significant inhibition of radiographic progression.
Integrated Motion Planning and Coordination for Industrial Vehicles

A growing interest in the industrial sector for autonomous ground vehicles has prompted significant investment in fleet management systems. Such systems need to accommodate on-line externally imposed temporal and spatial requirements, and to adhere to them even in the presence of contingencies. Moreover, a fleet management system should ensure correctness, i.e., refuse to commit to requirements that cannot be satisfied. We present an approach to obtain sets of alternative execution patterns (called trajectory envelopes) which provide these guarantees. The approach relies on a constraint-based representation shared among multiple solvers, each of which progressively refines trajectory envelopes following a least commitment principle.
Difference and Repetition

The best ebooks about Difference And Repetition that you can get for free here by download this Difference And Repetition and save to your desktop. This ebooks is under topic such as gilles deleuze difference and repetition difference and repetition mariusj preparing to learn from difference and repetition protevi gilles deleuze difference and repetition difference and repetition: on guy debord's films difference and repetition wrmail difference and repetition uksfp difference and repetition pdf book library deleuzeÃ¢Â€ÂTMs difference and repetition (phil 615) crn: 27134 gilles deleuzes difference and repetition gilles deleuzes deleuzeÃ ̄Â¿Â¢Ã ̄Â3⁄4Â€Ã ̄Â3⁄4ÂTMs difference and repetition by henry somers-hall repetition pdf difference and deleuze wordpress difference, repetition, and the n[on(e)-all]: the repetition and difference: a rhythmanalysis of pedagogic outline of gilles deleuze, diffÃƒÂ©rence et rÃƒÂ©pÃƒÂ©tition from colonization to globalization: difference or repetition and difference: a rhythmanalysis of pedagogic reading on the move geneseo migrant center and national the difference and repetition of gabriel tarde repetition and refrain your new wiki! wikispaces difference and repetition 310 conclusion: the postulate difference and repetition in deleuzeÃ¢Â€ÂTMs proustian sign and differences in the nonword repetition performance of which are the layers of difference and repetition? gilles deleuzes difference and repetition gilles deleuzes gilles deleuze's 'difference and repetition': a critical difference and repetition deleuze pdf kepbeenpdf difference and repetition pdf kepbeenpdfleswordpress difference and repetition european perspectives a series rhetorical analysis university academic success programs what difference does deleuze's difference make? difference and repetition wikipedia difference and repetition gilles deleuze google books deleuze, gilles | internet encyclopedia of philosophy
Gauged WZW models and non-Abelian duality.

We consider WZW models based on the non-semi-simple algebras that were recently constructed as contractions of corresponding algebras for semisimple groups. We give the explicit expression for the action of these models, as well as for a generalization of them, and discuss their general properties. Furthermore we consider gauged WZW models based on these non-semi-simple algebras and we show that they are equivalent to non-Abelian duality transformations on WZW actions. We also show that a general non-Abelian duality transformation can be thought of as a limiting case of the non-Abelian quotient theory of the direct product of the original action and the WZW action for the symmetry gauge group [ital H]. In this action there is no Lagrange multiplier term that constrains the gauge field strength to vanish. A particular result is that the gauged WZW action for the coset ([ital G][sub [ital k]][direct product][ital H][sub [ital l]])/[ital H][sub [ital k]+[ital l]] becomes in a certain limit, involving [ital l][r arrow][infinity], the dualized WZW action for [ital G][sub [ital k]] with respect to the subgroup [ital H].
Diversity of Emergent Dynamics in Competitive Threshold-Linear Networks

Threshold-linear networks consist of simple units interacting in the presence of a threshold nonlinearity. Competitive threshold-linear networks have long been known to exhibit multistability, where the activity of the network settles into one of potentially many steady states. In this work, we find conditions that guarantee the absence of steady states, while maintaining bounded activity. These conditions lead us to define a combinatorial family of competitive threshold-linear networks, parametrized by a simple directed graph. By exploring this family, we discover that threshold-linear networks are capable of displaying a surprisingly rich variety of nonlinear dynamics, including limit cycles, quasiperiodic attractors, and chaos. In particular, several types of nonlinear behaviors can co-exist in the same network. Our mathematical results also enable us to engineer networks with multiple dynamic patterns. Taken together, these theoretical and computational findings suggest that threshold-linear networks may be a valuable tool for understanding the relationship between network connectivity and emergent dynamics.
Pulmonary Complications, Ventilation and Blood Gases after Upper Abdominal Surgery

Forty patients who underwent elective cholecystectomy were examined preoperatively and during the first postoperative week by physical examination, measurement of FVC and FEV1, arterial pH and blood gas analyses, and chest x‐ray. Postoperative pulmonary complications (p.p.c.) were detected in 30 (75%) of the patients. Simple auscultation was the most sensitive tool in discovering p.p.c. , but 18 of the 30 patients with complications also had a pathological chest x‐ray.
ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion.

BACKGROUND & AIMS The Wilson protein (ATP7B) regulates levels of systemic copper by excreting excess copper into bile. It is not clear whether ATP7B translocates excess intrahepatic copper directly across the canalicular membrane or sequesters this copper into exocytic vesicles, which subsequently fuse with canalicular membrane to expel their contents into bile. The aim of this study was to clarify the mechanism underlying ATP7B-mediated copper detoxification by investigating endogenous ATP7B localization in the HepG2 hepatoma cell line and its ability to mediate vesicular sequestration of excess intracellular copper. METHODS Immunofluorescence microscopy was used to investigate the effect of copper concentration on the localization of endogenous ATP7B in HepG2 cells. Copper accumulation studies to determine whether ATP7B can mediate vesicular sequestration of excess intracellular copper were performed using Chinese hamster ovary cells that exogenously expressed wild-type and mutant ATP7B proteins. RESULTS In HepG2 cells, elevated copper levels stimulated trafficking of ATP7B to pericanalicular vesicles and not to the canalicular membrane as previously reported. Mutation of an endocytic retrieval signal in ATP7B caused the protein to constitutively localize to vesicles and not to the plasma membrane, suggesting that a vesicular compartment(s) is the final trafficking destination for ATP7B. Expression of wild-type and mutant ATP7B caused Chinese hamster ovary cells to accumulate copper in vesicles, which subsequently undergo exocytosis, releasing copper across the plasma membrane. CONCLUSIONS This report provides compelling evidence that the primary mechanism of biliary copper excretion involves ATP7B-mediated vesicular sequestration of copper rather than direct copper translocation across the canalicular membrane.
A PERFORMANCE ANALYSIS OF DELTA AND HUFFMAN COMPRESSION ALGORITHMS

With the recent trend in Information and Communication Technology, Storage and Transfer of data and Information are two vital issues which have Cost and Speed implication respectively. Large volume of data (text or image) is constantly being processed on the internet or on a Personal Computer, which has led to the Upgrade of current System. Hence the need for compression, which reduces storage capacity and effect Speed of transfer. Data Compression is the act of reducing the size of a file by minimizing redundant data. In a text file, redundant data can be frequently occurring characters or common vowels. This research involves a comparative performance analysis of Huffman and Delta Compression schemes. A compression program is used to convert data from an easy-to-use format (ASCII) to one optimized for compactness. Huffman and Delta algorithms were implemented using C#. Result was also presented on the efficiency of the former based on three parameters: the number of bit, compression ratio and percentage of compression. It was discovered that Huffman algorithm for data compression performs better, since it can store / transmit the least number of bits. The average compression percentage for Huffman and Delta algorithm was found to be 39% and 45% respectively. Which simply implies that for a large text file, Huffman algorithm will achieve a 39% reduction in the file size and as such increase the capacity of the storage medium.
A study of the experiences and perceptions of parents of Black and Minority Ethnic pupils statemented with autism in relation to the educational support provided for their children and for themselves.

ii DECLARATION . iii DEDICATION . iv ACKNOWLEDGEMENTS . v TABLE OF CONTENTS . vi LIST OF MAPS, TABLES AND FIGURES . x ABBREVIATED TERMS . xii Chapter One: Introduction. 1 1.0 Introduction . 2 1.1 Terminology used in the study . 3 1.2 Aims of the study . 4 1.3 The background and position of the researcher . 6 1.4 Educational needs of pupils with autism . 9 1.5 The context of the study . 10 1.5. 1 Data on BME pupils in education within the selected LA in Wales . 15 1.6 Theoretical framework for the study . 16 1.7 SEN on inclusion and support policies in the UK. 17 1.7. 1 Educational provision recognising BME community . 22 1.8 The rationale for the study . 23 Chapter Two: Literature Review . 24 2.0 Introduction . 25 2.1 BME parents and autism . 26 2.1.1 Review of studies on support services for parents . 26 2.1.2 The role of parents . 29 2.1.3 Parents’ responses to diagnosis of autism . 31 2.1.4 Relevance of cultural influence for parents . 32 2.1.5 The influence of religion in the context of autism as a disability . 36 2.2 Parental participation with support services . 37 2.2.1 Available support services for the need of parents. 37 2.3 Autism and inclusive education . 41
Cardiac Manifestations of Twin–to–Twin Transfusion Syndrome

This review addresses the physiology of monochorionic diamniotic (MC/DA) twins and the potential for twin–twin transfusion syndrome (TTTS). It focuses on the underlying cardiovascular pathophysiology of TTTS and the cardiovascular impact of TTTS for both the recipient and the donor twin. It explains the principles for assessment and monitoring of these cardiovascular changes and how these may be used to guide pregnancy management. Finally, it describes the effect of treatment on the altered hemodynamics and how this can influence pregnancy and perinatal management, as well as longer-term follow-up.
A Bayesian Network Decision Support System for Order Management in New Product Development

Recently, the way firms enter to markets is influenced by the customer requirements applying product improvement. Thus, market-driven product design and development is now a favorite research topic in the literature. Order management prediction for a new product help firms to overcome the future uncertainties. Here, we propose a decision support system for customers' order management in a new product development process. The drawback of complicated decision support problems are the complexities involved in interpreting causal relationships among decision variables. Therefore, Bayesian Network (BN) has shown excellent decision support competence due to its flexible structure allowing itself to extract appropriate and robust causal relationships among target variable and related explanatory variables. We make use of a decision support BN as a prediction aid for order management in a new product development process. system predicts customer purchasing behavior using a system dynamics approach based on three pieces of information: product attractiveness, customer preferences and satisfaction, and marketing strategy. It also estimates the long-term NCLV based on Markov analysis. This can help managers to determine which product will be most lucrative to launch and the kinds of marketing strategies that should be adopted for the new product. It also helps improve new product development in the future by collating up to date information on market and product attributes. In recent years, many conventional and market-based decision support systems for product design have been developed (3-7). New product development, from idea creation to product introduction, requires inter-departmental communication among designers, engineers, and marketing personnel. These highlight the key areas that ought to be considered in making decisions on new product development, including customer requirements, customer satisfaction, market demand, product quality, product design, and pricing. However, no decision support system takes all of the key areas into account at the same time. Furthermore, to achieve a competitive edge in a market, sensible decisions must be made about various aspects of new product development, such as product attributes, customer segment, and promotion and marketing strategies.
Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs.

D(2)-like dopamine receptors mediate functional changes via activation of inhibitory G proteins, including those that affect adenylate cyclase activity, and potassium and calcium channels. Although it is assumed that the binding of a drug to a single isoform of a D(2)-like receptor will cause similar changes in all receptor-mediated functions, it has been demonstrated in brain that the dopamine agonists dihydrexidine (DHX) and N-n-propyl-DHX are "functionally selective". The current study explores the underlying mechanism using transfected MN9D cells and D(2)-producing anterior pituitary lactotrophs. Both dopamine and DHX inhibited adenylate cyclase activity in a concentration-dependent manner in both systems, effects blocked by D(2), but not D(1), antagonists. In the MN9D cells, quinpirole and R-(-)-N-propylnorapomorphine (NPA) also inhibited the K(+)-stimulated release of [(3)H]dopamine in a concentration-responsive, antagonist-reversible manner. Conversely, neither DHX, nor its analogs, inhibited K(+)-stimulated [(3)H]dopamine release, although they antagonized the effects of quinpirole. S-(+)-NPA actually had the reverse functional selectivity profile from DHX (i.e., it was a full agonist at D(2L) receptors coupled to inhibition of dopamine release, but a weak partial agonist at D(2L) receptor-mediated inhibition of adenylate cyclase). In lactotrophs, DHX had little intrinsic activity at D(2) receptors coupled to G protein-coupled inwardly rectifying potassium channels, and actually antagonized the effects of dopamine at these D(2) receptors. Together, these findings provide compelling evidence for agonist-induced functional selectivity with the D(2L) receptor. Although the underlying molecular mechanism is controversial (e.g., "conformational induction" versus "drug-active state selection"), such data are irreconcilable with the widely held view that drugs have "intrinsic efficacy".
NESH Regulates Dendritic Spine Morphology and Synapse Formation

Background Dendritic spines are small membranous protrusions on the neuronal dendrites that receive synaptic input from axon terminals. Despite their importance for integrating the enormous information flow in the brain, the molecular mechanisms regulating spine morphogenesis are not well understood. NESH/Abi-3 is a member of the Abl interactor (Abi) protein family, and its overexpression is known to reduce cell motility and tumor metastasis. NESH is prominently expressed in the brain, but its function there remains unknown. Methodology/Principal Findings NESH was strongly expressed in the hippocampus and moderately expressed in the cerebral cortex, cerebellum and striatum, where it co-localized with the postsynaptic proteins PSD95, SPIN90 and F-actin in dendritic spines. Overexpression of NESH reduced numbers of mushroom-type spines and synapse density but increased thin, filopodia-like spines and had no effect on spine density. siRNA knockdown of NESH also reduced mushroom spine numbers and inhibited synapse formation but it increased spine density. The N-terminal region of NESH co-sedimented with filamentous actin (F-actin), which is an essential component of dendritic spines, suggesting this interaction is important for the maturation of dendritic spines. Conclusions/Significance NESH is a novel F-actin binding protein that likely plays important roles in the regulation of dendritic spine morphogenesis and synapse formation.
Additive Schwarz Iterations for Markov Chains

A convergence analysis is presented for additive Schwarz iterations when applied to consistent singular systems of equations of the form $Ax=b$. The theory applies to singular $M$-matrices with one-dimensional null space and is applicable in particular to systems representing ergodic Markov chains, and to certain discretizations of partial differential equations. Additive Schwarz can be seen as a generalization of block Jacobi, where the set of indices defining the diagonal blocks have nonempty intersection; this is called the overlap. The presence of overlap is known to accelerate the convergence of the methods in the nonsingular case. By providing convergence results, as well as some characteristics of the induced splitting, we hope to encourage the use of this additional computational tool for the solution of Markov chains and other singular systems. We present several numerical examples showing that additive Schwarz performs better than block Jacobi. For completeness, a few numerical experiments with block Gauss--Seidel and multiplicative Schwarz are also included.
Social Benefits in Urban China Determinants and Impact on Income Inequality in 1988 and 2002

This study provides the first set of empirical evidence on the determinants of social benefits received by urban families in China and the impact on income inequality using the China Household Income Project (CHIP) 1988 and 2002 data. It finds that the total urban social benefits strongly targeted the bottom pre-tax pre-transfer income decile. Cash transfers were negatively associated with income distribution in both years, while important in-kind benefits (namely health and food in 1988 and education in 2002) were positively related to income levels. The presence of elder members and higher education levels were significantly related to more total social benefits. Urban social benefits played a significant role in reducing income inequality in both 1988 and 2002. However, the social benefit transfers were not able to close the increasing income gap caused by the growing market income inequality of the period. As a result, post-tax post-transfer income inequality level in 2002 was higher still than in 1988.
A Cooperative Co-Evolutionary Genetic Neural Network and its Application

Considering that existing neural network's weights are randomly selected, hidden layer nodes are difficult to determine, the convergence speed is slow, and all these will easily lead to the problems such as local minimum values. In order to solve these problems, this article puts forward a kind of cooperative co-evolutionary genetic neural network. On the one hand, cooperative co-evolutionary genetic algorithm (CCGA) is introduced to optimize neural network structure, so as to solve the problem that the hidden neurons are difficult to determine, On the other hand, optimize neural network's connection weights, so as to improve the convergence speed and avoid falling into the local minimum values. The author established the model which is based on CCGA and so can simultaneously optimize the neural network's structure and weights. The algorithm is proved to be effective through the simulation experiment of stock forecast.
Organisation of subcortical pathways for sensory projections to the limbic cortex. I. Subcortical projections to the medial limbic cortex in the rat

Subcortical afferent projections to the medial limbic cortex were examined in the rat by the use of retrograde axonal transport of horseradish peroxidase. Small iontophoretic injections of horseradish peroxidase were placed at various locations within the dorsal and ventral cingulate areas, the dorsal agranular and ventral granular divisions of the retrosplenial cortex and the presubiculum. Somata of afferent neurons in the thalamus and basal forebrain were identified by retrograde labeling.
Cross-Cultural Perspectives on Intercultural Communication Competence

Abstract This study examined the process of developing intercultural communication competence (ICC) with particular attention to cross-cultural differences in communication patterns. A qualitative approach involving 40 interviews with Americans living in Sweden and Swedes living in the US was employed in order to gain a nuanced, in-depth, and contextual understanding of how immigrants and expatriates experience the process. Several differences in verbal and nonverbal communication patterns between the two cultures emerged. The findings provide insights into how ICC is developed differently across cultures, as well as how the cognitive, affective, and behavioral components of ICC are interrelated and influenced by culture-specific aspects.