Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term Management of Thymic Lymphoma in a Java Sparrow (Lonchura oryzivora)

Abstract A 4-year-old Java sparrow (Lonchura oryzivora) was diagnosed with thymic lymphoma based on the results of histopathologic evaluation and immunohistochemical staining of a Tru-cut biopsy sample. The bird was treated with chlorambucil (2 mg/kg PO) twice per week for the first 18 weeks, and the mass size, activity level, appetite, bowel function, and body weight were monitored weekly. At week 19, the bird became ill and anorexic, and the chlorambucil treatment was discontinued. The neoplasm grew rapidly during weeks 20 and 21, and the chlorambucil treatment was resumed at week 23. At week 28, the bird's overall condition worsened and the chlorambucil treatment was discontinued because no additional reduction in mass size had occurred. At week 29, prednisolone (2.2 mg/kg) was administered orally every 12 h for 31 weeks. At week 61, the patient became acutely ill, exhibiting anorexia and a decreased level of physical activity, and the owner elected to euthanatize the bird. This is the first report of long-term management of thymic lymphoma in a Java sparrow.
The ordered weighted geometric averaging operators

The ordered weighted averaging (OWA) operator was introduced by Yager. 1 The fundamental aspect of the OWA operator is a reordering step in which the input arguments are rearranged in descending order. In this article, we propose two new classes of aggregation operators called ordered weighted geometric averaging (OWGA) operators and study some desired properties of these operators. Some methods for obtaining the associated weighting parameters are discussed, and the relationship between the OWA and DOWGA operators is also investigated. © 2002 Wiley Periodicals, Inc.
All-fiber WDM optical crossconnect using ultrastrong widely tunable FBGs

We demonstrate an all-fiber wavelength-division-multiplexed optical crossconnect using ultrastrong fiber Bragg gratings (FBGs) with wide tunability. These FBGs have 0.2-nm bandwidths and can be tuned over /spl sim/52 nm due to a novel grating preparation technique to reduce mechanical strength degradation. There is negligible distortion in the transmission spectra while tuning the grating, and the crossconnect architecture uses cascades of these gratings for WDM operation. The ability to tune these >98% reflectivity gratings completely out of the entire WDM signal band minimizes the leakage of unwanted signal power and leads to the improvements of >10-dB crosstalk and >0.6-dB power penalty compared with conventional gratings.
Model infrared spectra of passively heated proto-planetary disks surrounding intermediate-mass pre-main-sequence stars

Aims. We study theoretical spectra at mid-infrared (5−40 μm) wavelengths of proto-planetary disks surrounding intermediate-mass pre-main-sequence stars. Observations show a wide range of spectral shapes and a rich variety in strength and shape of dust resonances. These strong variations in spectral shape reflect differences in the nature and spatial distribution of dust particles in the disk. The aim of this study is to establish what model parameters influence the mid-IR spectra of planet-forming disks. Methods. A grid of models of passively heated proto-planetary disks is used to calculate the infrared spectrum. We use hydrostatic equilibrium disk models and radiative transfer to calculate the emerging spectrum. We focus on the effects that different disk geometries (flaring, self-shadowed) and dust mineralogy have on the emerging 5−40 μm spectrum. We adopt four scenarios for the radial and vertical distribution of crystalline silicate dust. Results. In our model, the 23.5 μm forsterite band is more sensitive to emission from regions 5 percent) of crystalline silicates at a long distance from the star (>20−50 AU) show detectable emission in the 33.5 μm forsterite band. The carbon-dust abundance affects the strength of the dust resonances in the 10 μm spectral region, but not in the 30 μm region.
Biomass and Compositional Characteristics of Kaneohe Bay, Oahu, Hawaii, Phytoplankton Inferred from Regression Analysis

Concentrations of chlorophyll a (chI a), particulate carbon (PC), and particulate nitrogen (PN) measured on a weekly basis in the picoplankton and nano-plus-microplankton size fractions over a 2-yr period from 1986 to 1988 at a station near a former sewage outfall in Kaneohe Bay, Oahu, Hawaii, were compared to similar data collected in 1970, 1972, 1974, and 1976-1977 while sewage was being discharged into the bay, and in 1978-1979 immediately after diversion of the sewage. Particulate concentrations showed considerable temporal variability both within and between years. High concentrations were associated with periods of above-average rainfall. Heavy rains that occurred during two successive periods of spring tides produced chI a concentrations of over 40 mg m- 3 in January 1988, almost four times the highest concentration measured during the period of sewage discharges. Nutrients from land runoff as well as from decomposition of organisms killed by salinity stress were the apparent cause ofthis spectacular bloom. The bloom consisted almost entirely of nanoplankton and microplankton, but picoplankton accounted for 45 ± 14% of the chI a during the remainder of the 1986-1988 study. Phytoplankton C:N ratios were apparently unaffected by diversion of sewage from the bay and averaged within 10% of the Redfield ratio. This result implies that phytoplankton were growing at close to nutrient-saturated rates both before and after the sewage diversion. Nutrient budget calculations indicated that most ofthe growth has been supported by recycling within the bay. Phytoplankton C: chI and N: chI ratios estimated by regression analyses increased after the sewage diversion, apparently in response to the increase in average irradiance in the water column caused by the decline in seston concentrations. C: N ratios of picoplankton and nano-plus-microplankton under nutrient-saturated conditions were about 4.6 ± 0.3 and 6.2 ±O.8, respectively; the difference probably reflected the high con­ centration of nitrogen-containing pigments in some picoplankton. are generally favored over benthic algae as the degree of nutrient enrichment increases (Hansson 1988). Phytoplankton may thus serve as sensitive indicators of trophic state. Conceptually, phytoplankton response to nutrient enrichment may be in two ways, by a change in growth rate or by a change in bio­ mass (Caperon et al. 1971). When limiting nutrient concentrations are sufficiently high, relative growth rates as defined by Goldman (1980) are close to 1.0, and further nutrient enrichment will produce a response from the phytoplankton almost entirely in the form ofa biomass change and may favor species with higher absolute growth rate (J1.max)' When rela-
Global assessment of the antimicrobial activity of polymyxin B against 54 731 clinical isolates of Gram-negative bacilli: report from the SENTRY antimicrobial surveillance programme (2001-2004).

In total, 54 731 Gram-negative bacilli isolated worldwide between 2001 and 2004 from diverse sites of infection were tested for susceptibility to polymyxin B by the broth reference microdilution method, with interpretation of results according to CLSI (formerly NCCLS) guidelines. Polymyxin B showed excellent potency and spectrum against 8705 Pseudomonas aeruginosa and 2621 Acinetobacter spp. isolates (MIC50, < or = 1 mg/L and MIC90, 2 mg/L for both pathogens). Polymyxin B resistance rates were slightly higher for carbapenem-resistant P. aeruginosa (2.7%) and Acinetobacter spp. (2.8%), or multidrug-resistant (MDR) P. aeruginosa (3.3%) and Acinetobacter spp. (3.2%), when compared with the entire group (1.3% for P. aeruginosa and 2.1% for Acinetobacter spp.). Among P. aeruginosa, polymyxin B resistance rates varied from 2.9% in the Asia-Pacific region to only 1.1% in Europe, Latin America and North America, while polymyxin B resistance rates ranged from 2.7% in Europe to 1.7% in North America and Latin America among Acinetobacter spp. Polymyxin B also demonstrated excellent activity (MIC90, < or = 1 mg/L; > 98% susceptible) against Citrobacter spp. , Escherichia coli and Klebsiella spp. , but activity was more variable against Enterobacter spp. (MIC50, < or = 1 mg/L; 83.3% susceptible) and Stenotrophomonas maltophilia (MIC50, < or = 1 mg/L; 72.4% susceptible), and was very limited (MIC50, > 8 mg/L) against Burkholderia cepacia (11.8% susceptible), Serratia spp. (5.4% susceptible), indole-positive Proteus spp. (1.3% susceptible) and Proteus mirabilis (0.7% susceptible).
Sex differences and estrogen regulation of BDNF gene expression, but not propeptide content, in the developing hippocampus

Sex differences in adult brain function are frequently determined developmentally through the actions of steroid hormones during sensitive periods of prenatal and early postnatal life. In rodents, various cellular end points of the developing brain are affected by estradiol that is derived from the aromatization of circulating testosterone and/or synthesized within the brain. We have previously described a sex difference in neurogenesis in the hippocampus of neonatal rats that is modulated by estradiol. In this report, we examined a potential downstream regulator of the effects of estradiol on hippocampal cell proliferation by measuring gene expression of brain‐derived neurotrophin (BDNF) in male and female neonatal rats in response to estradiol. Males had higher baseline BDNF gene expression in dentate gyrus and CA1 regions of the hippocampus compared with females. Neonatal administration of exogenous estradiol resulted in opposite effects on BDNF expression in these areas of the neonatal hippocampus, such that BDNF transcripts increased in CA1 but decreased in dentate. Blocking endogenous estradiol signaling by antagonizing estrogen receptors decreased BDNF expression in the dentate of males, but not females, and had no effect in CA1. Interestingly, this sex difference and response to estradiol was not mirrored by translational output, as no differences in BDNF precursor peptide were observed. The sex‐ and region‐specific effects of estradiol on BDNF expression in the neonatal hippocampus suggest a complex functional relationship between these pleiotropic factors in regulating developmental neurogenesis. © 2016 Wiley Periodicals, Inc.
Türkiye'de İş Yaşamındaki Kent Kadınının Açmazı: Kariyer-Aile

Neoliberal dalganin neden oldugu donusumun etkisini salt ekonomik degil, kulturel ve sosyal alanlarda da guclu bir bicimde hissettirdigi 1980’li yillar ve sonrasinda bircok ulkede oldugu gibi Turkiye de gerek alt, gerekse ust yapisinda bircok degisimlere sahne olmustur. Karma ekonomiden piyasa ekonomisine gecisle birlikte degisime ugrayan sosyal yapi Turk toplumunun aile yasaminda da birtakim sarsintilara neden olmamis degildir. Ulkemizde istihdam ve egitim alanlarinda sayisinda belirgin bir artisin yasandigi bu donemde kent kadini, oncelikli olarak eskiye oranla daha fazla ekonomik ozgurluk kazanmasi sonucu, aile sorumluluklari yaninda kariyerini de atbasi goturme cabasi icerisinde olmakta, ancak geleneksel yapinin etkisi ile bu konuda kacinilmaz olarak acmazlarla karsilasmaktadir
Very low permittivity slot-fed dielectric resonator antennas with improved bandwidth for millimetre-wave applications

This paper introduces a simple method to increase the bandwidth of slot-fed dielectric resonator antennas (DRAs) for millimetre-wave applications. Bandwidth augmentation is achieved by decreasing the dielectric constant of DRAs while the critical coupling is obtained by properly adjusting the slot size and position. Two numerical methods, based on finite element method and finite integral technique, are used to verify the approach. A 10-dB impedance bandwidth of 27 percent is attained for DRAs with dielectric constant as low as 4 while the radiation properties remain similar to those of higher dielectric constant DRAs.
The therapeutic effect and mechanism of niacin on acute lung injury in a rat model of hemorrhagic shock: Down-regulation of the reactive oxygen species–dependent nuclear factor &kgr;B pathway

BACKGROUND The purpose of the current study was to investigate the protective effect of niacin on acute lung injury by the down-regulation of the nuclear factor &kgr;B (NF-&kgr;B) pathway in hemorrhagic shock (HS) rats. METHODS HS was induced in male Sprague-Dawley rats by withdrawing blood to maintain a mean arterial pressure of 20 mm Hg to 25 mm Hg for 40 minutes. The rats were resuscitated by the reinfusion of the drawn blood, and a vehicle (HS), a low-dose of niacin (360 mg/kg, HS + LD-NA), or a high dose of niacin (1,080 mg/kg, HS + HD-NA) were administered orally. The survival of the subjects was observed for 72 hours, and a separate set of animals was killed at 6 hours after HS induction. We measured cytoplasmic phosphorylated inhibitor &kgr;B-&agr; and inhibitor &kgr;B-&agr; expressions, nuclear NF-&kgr;B p65 expression, NF-&kgr;B p65 DNA-binding activity, MEK partner 1 activity, tumor necrosis factor &agr; (TNF-&agr;), interleukin 6 (IL-6), IL-8, nicotinamide adenine dinucleotide (NAD+), reduced nicotinamide adenine dinucleotide phosphate, reduced glutathione, glutathione disulfide, malondialdehyde levels, and histologic damage in the lung tissue. We also measured TNF-&agr;, IL-6, and IL-8 levels in the serum. RESULTS The survival rates of the sham, HS, HS + LD-NA, and HS + HD-NA groups were 6 of 6 (100%), 0 of 9 (0%), 1 of 9 (11.1%), and 3 of 9 (33.3%), respectively. A high dose of niacin increased lung NAD+, nicotinamide adenine dinucleotide phosphate levels, and glutathione–glutathione disulfide ratios; decreased lung malondialdehyde levels; down-regulated the NF-&kgr;B pathway; suppressed TNF-&agr;, IL-6, and IL-8 levels in the lung tissue and serum; and attenuated histologic lung damage. CONCLUSION A high dose of niacin attenuated lung inflammation, suppressed proinflammatory cytokine release, reduced histologic lung damage, and improved survival after HS in rats. Its therapeutic benefits were associated with the down-regulation of the reactive oxygen species–dependent NF-&kgr;B pathway.
PERIPHERAL VASCULAR DISEASE 3-Year Outcomes of the OLIVE Registry , a Prospective Multicenter Study of Patients With Critical Limb Ischemia A Prospective , Multi-Center , Three-Year Follow-Up Study on Endovascular Treatment for Infra-Inguinal Vessel in Patients With Critical Limb Ischemia

OBJECTIVES This study sought to investigate the 3-year follow-up results of OLIVE registry patients. BACKGROUND Although favorable 12-month clinical outcomesafter endovascular therapy (EVT) inOLIVE registry patients with critical limb ischemia (CLI) from infrainguinal disease have been reported, long-term results after EVT remain unknown. METHODS This was a prospective multicenter registry study that consecutively enrolled patients who received infrainguinal EVT for CLI. The primary outcomewas 3-year amputation-free survival (AFS), whereas secondary outcomemeasures were 3-year freedom frommajor adverse limb events (MALE), wound-free survival, and wound recurrence rate. Prognostic predictors for each outcome were also elucidated by Cox proportional hazard regression analysis or the log-rank test. RESULTS The completion rate of 3-year follow-up was 95%. Three-year AFS, freedom from MALE, and wound-free survival rates were 55.2%, 84.0%, and 49.6%, respectively. Wound recurrence out to 3 years was 43.9%. After multivariable analysis, age (hazard ratio [HR]: 1.43, p 1⁄4 0.001), body mass index #18.5 (HR: 2.17, p 1⁄4 0.001), dialysis (HR: 2.91, p < 0.001), and Rutherford 6 (HR: 1.64, p 1⁄4 0.047) were identified as predictors of 3-year major amputation or death. Statin use (HR: 0.28, p 1⁄4 0.02), Rutherford 6 (HR: 2.40, p 1⁄4 0.02), straight-line flow to the foot (HR: 0.27, p 1⁄4 0.001), and heart failure (HR: 1.96, p 1⁄4 0.04) were identified as 3-year MALE predictors. Finally, CLI due to isolated below-the-knee lesion was a wound recurrence predictor (HR: 4.28, p# 0.001). Three-year survival, freedom from major amputation, and reintervention rates were 63.0%, 87.9%, and 43.2%. CONCLUSIONS In CLI patients with infrainguinal lesions, 3-year clinical results of EVT were reasonable despite high reintervention and moderate ulcer recurrence rate. (A Prospective, Multi-Center, Three-Year Follow-Up Study on Endovascular Treatment for Infra-Inguinal Vessel in Patients With Critical Limb Ischemia [OLIVE 3-Year Follow-Up Study]; UMIN000014759) (J Am Coll Cardiol Intv 2015;8:1493–502) © 2015 by the American College of Cardiology Foundation. ABBR EV I A T I ON S
Active Learning of Object and Body Models with Time Constraints on a Humanoid Robot

In this paper, we propose an active learning approach applied to a music performance imitation scenario. The humanoid robot iCub listens to a human performance and then incrementally learns to use a virtual musical instrument in order to imitate the given sequence. This is achieved by first learning a model of the instrument, needed to locate where the required sounds are heard in a virtual keyboard layed out in a tactile interface. Then, a model of its body capabilities is also learnt, which serves to establish the likelihood of success of the actions needed to imitate the sequence of sounds and to correct the errors made by the underlying kinematic controller. It also uses self-evaluation stages to provide feedback to the human instructor, which can be used to guide its learning process.
Audio Recurrence Contribution to a Video-based TV Program Structuring Approach

This paper addresses the problem of unsupervised TV programs structuring. Program structuring allows direct and non linear access to the desired parts of a program. Our work addresses the structuring of recurrent TV programs like news, entertainment programs, TV shows, TV magazines. In a previous work we proposed a program structuring method based on the detection of video recurrences. In this paper we extend our study to audio recurrences and verify their influence on the final structuring. We evaluate the structuring results on both approaches (audio and video) separately and jointly. We use for evaluation a 62 hours dataset corresponding to 97 episodes of TV programs.
Competitive, enzyme-linked immunosorbent assay for toxic shock syndrome toxin 1

We developed a competitive, enzyme-linked immunosorbent assay for the quantitation of toxic shock syndrome toxin 1 (TSST-1). Polyvalent immunoglobulin G from immunized rabbits was used as the capture antibody, and alkaline phosphatase conjugated to purified toxin served as the indicator enzyme. A standard curve was generated with each experiment, from which the concentration of toxin in culture supernatants was extrapolated. The assay was useful for determining toxin concentrations of 0.03 to 0.5 micrograms/ml, which is a substantial, practical improvement over immunodiffusion methods. Staphylococcal enterotoxins A through E were not significantly cross-reactive in the assay, and staphylococcal protein A did not interfere with quantitation of TSST-1. By testing a variety of staphylococcal strains, we found 100% concordance between toxin determinations made with our assay and those made by the investigators from whom the strains were obtained. The competitive, enzyme-linked immunosorbent assay is a highly reproducible, inexpensive means of determining TSST-1 concentrations and may have broad applicability in the field of toxic shock research.
Path‐sensitive alias analysis for data flow testing

This paper describes a new approach to performing data flow testing in the presence of aliasing, and a tool based on this method. The technique is based on the observation that, under certain reasonable assumptions, one can statically determine which variables are aliased whenever control reaches a given program point via a particular path. Furthermore, one can group together paths that behave similarly with respect to aliasing and represent them by regular expressions. The resulting test requirements demand that the test data execute representatives of particular sets of paths between variable definitions and uses. Copyright © 1999 John Wiley & Sons, Ltd.
Growth Characteristics of a Pseudomonad Which Utilizes Pyridoxine or Pyridoxamine as a Carbon Source

Cultural characteristics of Pseudomonas MA-1, which has been extensively used as a source of enzymes that degrade vitamin B6, confirm its classification as a pseudomonad. The organism requires biotin for growth; any one of several amino acids is also required for growth when pyridoxine (but not when glucose) serves as the energy source. Growth of Pseudomonas MA-1 is inhibited by one or more unidentified substances formed when pyridoxine is autoclaved with the medium. Modified cultural conditions are described which permit the large-scale growth of the organism with pyridoxine as carbon source.
Dopant-Segregated Schottky Silicon-Nanowire MOSFETs With Gate-All-Around Channels

In this letter, we demonstrated dopant-segregated Schottky (DSS) p-MOSFET with gate-all-around silicon-nanowire (SiNW) channel of 10 nm in diameter. The DSS transistor shows improved performance as compared to a reference Schottky barrier (SB) transistor without dopant segregation. The DSS transistor shows I ON of 319 muA/mum at a low gate overdrive of -0.6 V, high I ON/I OFF ratio (~105), and short-channel performance with subthreshold slope ~90 mV/dec down to 100-nm gate length with relatively thick (6 nm) deposited gate oxide. The DSS transistor also shows significant reduction (~40times lower) in the series resistance as compared to the SB transistor. The origin of the improved performance of the DSS is the thin dopant layer segregated at the nickel monosilicide/SiNW point contact which results in the enhanced hole injection at the source side and the suppressed electron injection at the drain side.
Bayesian quantile regression for nonlinear mixed-effects joint models for longitudinal data in the presence of mismeasured covariate errors

ABSTRACT Quantile regression (QR) models have recently received increasing attention in longitudinal studies where measurements of the same individuals are taken repeatedly over time. When continuous (longitudinal) responses follow a distribution that is quite different from a normal distribution, usual mean regression (MR)-based linear models may fail to produce efficient estimators, whereas QR-based linear models may perform satisfactorily. To the best of our knowledge, there have been very few studies on QR-based nonlinear models for longitudinal data in comparison to MR-based nonlinear models. In this article, we study QR-based nonlinear mixed-effects (NLME) joint models for longitudinal data with non-central location and outliers and/or heavy tails in response, and non-normality and measurement errors in covariate under Bayesian framework. The proposed QR-based modeling method is compared with an MR-based one by an AIDS clinical dataset and through simulation studies. The proposed QR joint modeling approach can be not only applied to AIDS clinical studies, but also may have general applications in other fields as long as relevant technical specifications are met.
Past and Present

This chapter presents a diachronic vision of the evolution of the main classical games in the computer followed by a look at computer-assisted teaching until the mid-nineties. Later, systems aimed at education in off-line and online support are analyzed simultaneously. Through this diachronic study, how many design features have endured until the present day can be seen.