Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of duloxetine on painful physical symptoms in major depressive disorder for patients with clinically significant painful physical symptoms at baseline: a meta-analysis of 11 double-blind, placebo-controlled clinical trials.

OBJECTIVE To review efficacy of duloxetine for physical symptoms and depressive illness in patients with at least mild to moderate major depressive disorder (MDD; DSM-IV) and clinically significant painful physical symptoms at baseline. DATA SOURCES Global database of duloxetine clinical trials (Eli Lilly and Company). STUDY SELECTION All 11 acute, double-blind, placebo-controlled studies of duloxetine (7 with duloxetine 60-mg doses and 4 with non-60-mg doses) in the database that used a scale to measure painful physical symptoms and were completed before March 17, 2011. DATA EXTRACTION For each study, patients with clinically significant pain levels at baseline (Visual Analog Scale overall pain rating ≥ 30, Numerical Rating Scale score ≥ 3, or Brief Pain Inventory 24-hour average pain rating ≥ 3) were selected in order to determine the effect sizes of duloxetine (compared with placebo for each trial) on the pain and depression measures. Overall effect sizes for both painful physical symptoms and MDD were obtained from the mean of individual-trial effect sizes, and each effect size was weighted relative to the number of patients within each study. DATA SYNTHESIS The overall mean effect sizes were as follows: painful physical symptoms-60-mg trials, 0.29 (95% CI, 0.06 to 0.52); non-60-mg trials, 0.13 (95% CI, -0.19 to 0.45); MDD-60-mg trials, 0.29 (95% CI, 0.18 to 0.40); non-60-mg trials, 0.16 (95% CI, 0.00 to 0.32). Across the 11 studies, the weighted effect size for painful physical symptoms was 0.26 (95% CI, 0.00 to 0.51) and for MDD, 0.25 (95% CI, 0.16 to 0.34). CONCLUSIONS According to this meta-analysis, duloxetine 60 mg once daily is as effective in improving painful physical symptoms as it is for depression in patients with MDD and clinically significant painful physical symptoms. The results of this meta-analysis indicate that duloxetine has small effect sizes in reducing painful physical symptoms and depressive symptoms in patients with MDD and clinically significant pain levels at baseline. Thus, the results of the study permit one to conclude that duloxetine has a clinically significant impact on painful physical symptoms and in reducing the severity of depressive symptoms. However, the results do not address its efficacy compared to other alternatives, as in all studies the comparator was placebo.
Open system architecture for robotics and mechatronics with modulated component (MHS2005 & Micro-Nano COE)

Practical intelligent robot covers wide application field and also various mechanisms or control software without high cost. If the system architecture or component of robot is developed based on standardized concept, it makes the robot easy design, easy application or easy maintenance and reduces the robot costs hugely. Now, we are developing the hardware component named NPA (network plug in actuator) and outdoor mobile robot "econo-vehicle" designed by open-arts and software frame work named "Open RTM-AIST". This paper shows the concept and out line of NPA and econo-vehicle.
Hybrid Semiconductor Detectors for High Spatial Resolution Phase-contrast X-ray Imaging

When conventional x-ray radiography presents inadequate absorption-contrast, higher sensitivity can be achieved using phase-contrast methods. The implementation of phasecontrast x-ray imaging using propagation-based techniques requires stringent spatial resolution requirements that necessitate lengthy propagation distances and thin (and hence low detection efficiency) scintillator-based detectors. Thus, imaging throughput is limited, and the absorbed dose in the sample can be unacceptable for radiation sensitive life science and biomedical applications. This work develops hybrid amorphous selenium and complementary metal-oxide-semiconductor detectors with a unique combination of high spatial resolution and detection efficiency for hard x-rays. A semiconductor fabrication process was developed for largearea compatible vertical detector integration by back-end processing. Characterization of signal and noise performance using Fourier-based methods was performed by modulation transfer function, noise power spectrum, and detective quantum efficiency experiments using radiography and microfocus x-ray sources. The measured spatial resolution at each stage of detector development was one of the highest, if not the highest reported for hard x-rays. In fact, charge carrier spreading from xray interactions with amorphous selenium was shown physically larger than the pixel pitch for the first time. A simultaneous factor of four improvement in detection efficiency compared to thin gadolinium oxysulfide-based scintillator detectors was also achieved, despite the detector being a relatively unoptimized prototype. Fast propagation-based phase-contrast x-ray imaging in compact geometries is demonstrated using a conventional microfocus source. This simple implementation of the phasecontrast technique was applied to imaging the mouse stifle joint. Using propagation-based edge-enhancement the articular cartilage was delineated, opening the possibility of studying diseases such as osteoarthritis using a compact, relatively simple laboratory setup. This research suggests that hybrid semiconductor technology offers the potential to fill the large performance deficit in high spatial resolution scintillator-based detectors for propagation-based phase-contrast x-ray imaging.
The effects of gender variety and power disparity on group cognitive complexity in collaborative learning groups

This study sets up to test the extent to which gender variety moderates the impact of power disparity on group cognitive complexity (GCC) and satisfaction with the group in a collaborative learning setting. Using insights from gender differences in perceptions, orientations and conflict handling behavior in negotiation, as well as gender differences in exerting social influence in small group settings we hypothesize that gender variety alleviates the negative impact of power disparity on GCC and satisfaction. We test this hypothesis in a sample of 110 student groups and our results show that for high gender variety, power disparity has a small positive effect on GCC, while for low gender variety power disparity has a negative effect on GCC. In a similar vein we show that in gender homogeneous groups, power disparity has a negative association with satisfaction, while for mixed-gender groups the association between the two is not significant. We discuss (1) the implications of these results for the management of diversity in educational and organizational settings and (2) the use of cognitive mapping as a comprehensive evaluation tool for collaborative learning effectiveness.
Direct Observation of the “Oxygen Paradox” in Single Rat Ventricular Myocytes

By phase contrast microscopy with video length tracking, we followed the sequence of morphological changes in individual isolated rat ventricular myocytes during anoxia followed by reoxygenation. Cells appeared normal during early anoxia. After a duration of anoxia t1, which varied from 17–47 minutes in different cells, each cell abruptly contracted an average of 33% in length to an inert rectangular form presumed to be a rigor state. Cells which were reoxygenated before the onset of rigor showed normal morphology and an unchanged extent of shortening on field stimulation, compared to control. Cells that were reoxygenated after a time in the rigor state, T2, either partially recovered to a shortened rectangular form capable of stimulated twitches or rounded up rapidly to a disordered hypercontracture form. The distribution of t1 was the same for cells which recovered and which hypercontracted. In contrast, the outcome of reoxygenation depended markedly on T2: all cells that were reoxygenated after less than 10 minutes of rigor recovered function, whereas all cells that spent more than 20 minutes in rigor hypercontracted when reoxygenated. The hypercontracture appears to be the cellular analog of the ‘oxygen paradox’ in whole hearts. Its occurrence is reliably related to duration of rigor state but not to duration of hypoxia, because of marked cellular variability in the time of onset of rigor.
12.5-Gb/s Full-Rate CDR With Wideband Quadrature Phase Shifting in Data Path

A 12.5-Gb/s full-rate clock and data recovery (CDR) circuit that utilizes an open-loop quadrature clock generator for wideband 90° phase shifting in the data path is presented. The differential clock from a voltage-controlled oscillator (VCO) is split into quadrature phases and subsequently mixed with data to provide in-phase and quadrature components of the data over a broad range of frequencies in the vicinity of the nominal data rate. The quadrature data phases are employed for the detection of clock phase misalignment in a mixer-based phase detector. A proof-of-concept prototype chip that integrates the critical building blocks of the proposed CDR is fabricated in a 90-nm CMOS technology. The CDR achieves a bit error rate of <; 10-12 in response to 231 - 1 pseudorandom-binary-sequence data, while the chip (which excludes VCO) consumes 84 mW from a 1.2-V supply.
griffith . edu . au Lighting Analysis and Texture Modification of 3 D Human Face Scans

The 3D scanning of human faces is an important tool to acquire accurate shape and texture information of heads and faces for both animation and recognition purposes. One of the most popular scanning tools is Cyberware head and face 3D colour scanner. Currently, 3D face databases scanned using the Cyberware head and face 3D colour scanner databases are publicly available and have been used in many face recognition system as the training data, one of which is USF human ID 3-D database. The mechanism of facial texture capturing, however, remains unclear due to the special settings of the light sources during scanning. The direct application of the acquired texture intensity as the albedo of the face surfaces leads to suboptimal modelling results. This paper analyses the lighting configuration of the scanner and proposes an appropriate reflectance model to describe the reflecting mechanism when scanning. The texture modifications can be carried on in the existing scanning results without any further scans. Experiment results show that the proposed reflectance model can better approximate the reflecting situation of scanning so that the acquired textures can be directly used as diffuse reflectance coefficients and achieve better rendering results.
An unusual cause of “appendicular pain” in a young girl: mesenteric cystic lymphangioma

Pain of the right iliac fossa in young girls can relate to several pathologies of the gastrointestinal and genitor-urinary tract. On the other hand, lymphangiomas in the peritoneal cavity are extremely rare. We report the case of a young woman with pain in the right iliac fossa caused by a cystic lymphangioma. A 17-year-old caucasian female patient presented with abdominal pain in the right iliac fossa and flank of a 1-month duration. The patient was apyrexic and laboratory tests were negative. CT/MRI of abdomen showed a cystic mass (max diameter 60 mm) in the retrocaecl adipose tissue in connection with the caecum and appendix. The patient underwent a total excision of the lesion and appendicectomy. Histopathological examination was consistent with the diagnosis of mesenteric lymphangioma. This case shows a rare but possible cause of right iliac fossa pain in young women to be considered in the differential diagnosis.
Participant recruitment in an online era: A reflection on ethics and identity

In this article I reflect on my experiences of using Facebook as a recruitment tool. Although there were many benefits associated with using this method of recruitment, there were also several unanticipated ethical dilemmas that arose. This article reflects on these dilemmas, locating them within some broader concerns around online research and privacy, and considers some potential avenues for avoiding similar issues in future research. It became apparent that these ethical issues were heightened for me as a doctoral researcher in a process of identity transition. I consider how this state of ‘shifting’ identity heightened my experience of these ethical tensions, and brought to the fore questions around online identity management and ways of ‘doing’ identity online.
Feasibility and compliance in a nutritional primary prevention trial in infants at increased risk for type 1 diabetes

Aim: The international Trial to Reduce IDDM in the Genetically at Risk (TRIGR) was launched to determine whether weaning to a highly hydrolysed formula in infancy reduces the incidence of type 1 diabetes in children at increased genetic disease susceptibility. We describe here the findings on feasibility and compliance from the pilot study.
Semi-global robust output regulation for a class of singular nonlinear systems via nonlinear internal model

ABSTRACT Most of existing results on robust output regulation problem of singular nonlinear systems are limited to local solutions. In this paper, the semi-global robust output regulation problem for a class of singular nonlinear systems is investigated by using a nonlinear internal model. Attaching a nonlinear internal model to the singular nonlinear system yields an augmented singular nonlinear system whose semi-global robust stabilisation solution leads to the solution of the semi-global robust output regulation problem of the original singular nonlinear system. The solvability conditions of the semi-global output regulation problem are established by addressing the solvability of the robust stabilisation problem of augmented singular nonlinear system. Finally, a numerical simulation example is used to illustrate the design of the semi-global regulator for the singular nonlinear systems.
EZH 2 overexpression in natural killer / T-cell lymphoma confers growth advantage independently of histone methyltransferase activity Running Title : EZH 2 in natural killer / T-cell lymphoma

The role of EZH2 in cancer is complex and may vary depending on the cellular context. We found that EZH2 is aberrantly overexpressed in the majority of natural killer / T-cell lymphoma (NKTL), an aggressive lymphoid malignancy with very poor prognosis. We show that EZH2 upregulation is mediated by MYC-induced repression of its regulatory miRNAs and EZH2 exerts oncogenic properties in NKTL. Ectopic expression of EZH2 in both primary NK cells and NKTL cell lines lead to a significant growth advantage. Conversely, knock-down of EZH2 in NKTL cell lines results in cell growth inhibition. Intriguingly, ectopic EZH2 mutant deficient for histone methyltransferase activity is also able to confer growth advantage and rescue the growth inhibition upon endogenous EZH2 depletion in NKTL cells, indicating an oncogenic role of EZH2 independent of its gene silencing activity. Mechanistically, we show that EZH2 directly promotes the transcription of Cyclin D1 and this effect is independent of its enzymatic activity. Furthermore, depletion of EZH2 using a PRC2 inhibitor DZNep significantly inhibits growth of NK tumor cells. Therefore, our study has uncovered an oncogenic role of EZH2 independent of its methyltransferase activity in NKTL, and suggests that targeting EZH2 may have therapeutic utility in this lymphoma. For personal use only. on October 4, 2017. by guest www.bloodjournal. org From
Literacy programs and language learning: A qualitative study of the beliefs and perceptions of international students' spouses learning English in an informal literacy center

This qualitative research study explores the beliefs and perceptions of the spouses of adult international students regarding the ESL literacy programs offered at a unique University Center (UC) for international students and their families. It was intended to provide an understanding of the adult spousal sojourners’ beliefs and perceptions of the literacy programs within the context of their cultural backgrounds. The goal was to understand how people of various cultural backgrounds perceived the UC’s teaching methods, models, and learning environment. The study was based on interviews and participant observations with spouses of international students from diverse cultural backgrounds who accompanied their husbands or wives to the United States of America for secondary purposes. Data were analyzed using inductive thematic analysis and concepts from symbolic interactionism (Blumer, 1969), critical theory, affective, and sociocultural theories of language learning. Findings included perceptions of the learning environment as the study intended, including that diverse cultural models influenced participants’ learning experiences at the UC, and the welcoming environment and its activities facilitated cross-cultural communication and language learning. In addition, some findings were relevant to the students’ secondary positionality as sojourners accompanying their spouses to the United States of America. Language learning and secondary positionality symbolized multiple meanings in the participants’ respective experiences. Students often felt a sense of “nothingness” in the host society in giving up their professional careers to accompany their spouses and encountered both struggles with and empowerment from language learning in pursuit of their new personal and professional goals. A notable finding was the symbolic role of grammar in the language program to connote language mastery and good teaching beyond its power as a tool of language learning. Language learning, in turn, symbolized access, social adjustment, bonding, liberation, and empowerment. The study concluded with emphasizing the primacy of language learning for the students’ adjustment and socialization in the host society. The implications are that language learning is a crucial “lifeline” and tool of survival; thus the students’ beliefs and perceptions of learning should be duly considered while designing literacy programs and interpreted in relation to their culture and the learning environment.
Compiling Stream Applications for Heterogeneous Architectures

Heterogeneous processing systems have become the industry standard in almost every segment of the computing market from servers to mobile systems. In addition to employing shared/distributed memory processors, the current trend is to use hardware components such as field programmable gate arrays (FPGAs), single instruction multiple data (SIMD) engines and graphics processing units (GPUs) in heterogeneous systems. As a result of this trend, extracting maximum performance requires compilation to highly heterogeneous architectures that include parts with different memory and computation models. Although there has been significant amount of research on programing each of these architectures individually, targeting a heterogeneous system without specializing an application to each component separately is still an open problem. Besides performance, the portability of an application between different pieces of a system and retargetability to various heterogeneous architectures is a significant challenge for programmers. To efficiently exploit the heterogeneity, it is necessary to have a programming model that provides a higher-level of abstraction to the programmer and the related compilation framework. In this thesis, we first focus on enabling a write-once programming paradigm in the context of the stream programming model for various components of heterogeneous systems. We mainly focus on FPGAs, SIMD engines and GPUs as these architectures will play an important role in accelerating various parts of applications on heterogeneous systems. We introduce several compiler optimizations that facilitate portability and retargetability while achieving high performance. As a result of our compilation system, programmers can write a program once and efficiently run it on different components of a system. Second, we focus on an important challenge that arises in heterogeneous systems when there are dynamic resource changes. The ability to dynamically adapt a running application to a target architecture in the face of changes in resource availability (e.g., number of cores, available memory or bandwidth) is crucial to a wider adoption of heterogeneous architectures. In this work, we introduce a hybrid flexible compilation framework that facilitates dynamic adaption of applications to the changing characteristics of the underlying architecture.
Visual pathways from the perspective of cost functions and multi-task deep neural networks

Vision research has been shaped by the seminal insight that we can understand the higher-tier visual cortex from the perspective of multiple functional pathways with different goals. In this paper, we try to give a computational account of the functional organization of this system by reasoning from the perspective of multi-task deep neural networks. Machine learning has shown that tasks become easier to solve when they are decomposed into subtasks with their own cost function. We hypothesize that the visual system optimizes multiple cost functions of unrelated tasks and this causes the emergence of a ventral pathway dedicated to vision for perception, and a dorsal pathway dedicated to vision for action. To evaluate the functional organization in multi-task deep neural networks, we propose a method that measures the contribution of a unit towards each task, applying it to two networks that have been trained on either two related or two unrelated tasks, using an identical stimulus set. Results show that the network trained on the unrelated tasks shows a decreasing degree of feature representation sharing towards higher-tier layers while the network trained on related tasks uniformly shows high degree of sharing. We conjecture that the method we propose can be used to analyze the anatomical and functional organization of the visual system and beyond. We predict that the degree to which tasks are related is a good descriptor of the degree to which they share downstream cortical-units.
5-Methylcytosine is not detectable in Saccharomyces cerevisiae DNA

We examined the DNA of Saccharomyces cerevisiae by both HpaII-MspI restriction enzyme digestion and high-performance liquid chromatography analysis for the possible presence of 5-methylcytosine. Both of these methods failed to detect cytosine methylation within this yeast DNA; i.e., there is less than 1 5-methylcytosine per 3,100 to 6,000 cytosine residues.
ARABIDOPSIS THALIANA HOMEOBOX GENE1 Establishes the Basal Boundaries of Shoot Organs and Controls Stem Growth[W]

Apical meristems play a central role in plant development. Self-renewing cells in the central region of the shoot meristem replenish the cell population in the peripheral region, where organ primordia emerge in a predictable pattern, and in the underlying rib meristem, where new stem tissue is formed. While much is known about how organ primordia are initiated and their lateral boundaries established, development at the interface between the stem and the meristem or the lateral organs is poorly understood. Here, we show that the BELL-type ARABIDOPSIS THALIANA HOMEOBOX GENE1 (ATH1) is required for proper development of the boundary between the stem and both vegetative and reproductive organs and that this role partially overlaps with that of CUP-SHAPED COTYLEDON genes. During the vegetative phase, ATH1 also functions redundantly with light-activated genes to inhibit growth of the region below the shoot meristem. Consistent with a role in inhibiting stem growth, ATH1 is downregulated at the start of inflorescence development and ectopic ATH1 expression prevents growth of the inflorescence stem by reducing cell proliferation. Thus, ATH1 modulates growth at the interface between the stem, meristem, and organ primordia and contributes to the compressed vegetative habit of Arabidopsis thaliana.