Miracle-dz/UniFAR-FTUs huggingface dataset:
CSKU GPRF-QE for Medical Topic Web Retrieval

Patients and their relatives have more chances to access their healthinformation in a form of discharge summary. Most of them do not totally understand contents in the discharge summary. The ShARe/CLEF eHealth Evaluation Lab organized a shared task for improving retrieval medical information from the web. Queries of this task are formulated based on information in discharge summaries. This paper investigates efficiency of query expansion using external collection. Co-occur terms in pseudo-relevance feedback of Genomics collection are selected and re-weighted based on Rocchio’s formula with dynamic tunable parameters of pseudo-relevance part. LUCENE, vector space model, is baseline retrieval tool. The proposed expansion method improves from baseline in all level cut of nDCG and best perform in P@10 of 3 topics. Using biomedical related collection such as Genomics is useful for medical topics retrieval.
The Rhetoric of Educational Reform

This article is an examination of the language of recent large-scale education reform in England, New Zealand, and the Canadian provinces of Alberta and Manitoba. In each jurisdiction, we review both the official documents and the parliamentary debate around a set of major educational reforms, looking at both the similarities and differences between jurisdictions and at the overall nature of official discourse. Although some similar rhetoric was used in all four settings, we conclude that the differences in justifications were more significant than the commonalities. Our analysis supports a view of official rhetoric as being primarily symbolic and intended to create or support particular definitions of problems and solutions, but also as shaped by the historical context, institutional structure, and political culture of each setting.
Evaluation of weight sparsity regularizion schemes of deep neural networks applied to functional neuroimaging data

The paper presented a systematic evaluation of the weight sparsity regularization schemes for the deep neural networks applied to the whole brain resting-state functional magnetic resonance imaging data. The weight sparsity regularization was deployed between the visible and hidden layers of the Gaussian-Bernoulli restricted Boltzmann machine (GB-RBM), in which the L0-norm based non-zero value ratio and L1-/L2-norm based Hoyer's sparseness were used to define the weight sparsity. Also, the weight sparsity regularization schemes between the two consecutive layers (i.e. layer-wise) and between the layer and the node in the subsequent layer (i.e. node-wise) were compared in terms of the convergence property. Finally, the reproducibility of 10 sets of weight features extracted from the GB-RBMs trained using 10 sets of random initial weights was evaluated.
Glucose Metabolism Gene Variants Modulate the Risk of Pancreatic Cancer

Long-term type 2 diabetes is a known risk factor for pancreatic cancer (PC). We hypothesized that genetic variants in glucose metabolism modify individual susceptibility to PC, especially those associated with diabetes. We retrospectively genotyped 26 single-nucleotide polymorphisms of 5 glucose metabolism genes: glucokinase (GCK), glutamine-fructose-6-phosphate transaminase 1 (GFPT1), glucose phosphate isomerase (GPI), hexokinase 2 (HK2), and O-linked N-acetylglucosamine transferase (OGT) in a case–control study of PC conducted at MD Anderson during 2004 to 2010. Initial genotyping was conducted in 706 patients with PC and 706 cancer-free controls by using the Sequenom method. A HK2 genotype (R844K) with low frequency of homozygous variant was further examined in additional 948 patients and 476 controls. In the combined set of 1,654 cases and 1,182 controls, we showed a significant association of the HK2 R844K GA/AA genotype with reduced PC risk (OR = 0.78; 95% CI, 0.64–0.94; P = 0.009) and a significant interaction with diabetes (Pinteraction < 0.001). The HK2 R844K GA/AA genotype was associated with a reduced risk of PC among nondiabetic individuals (OR = 0.68; 95% CI, 0.56–0.83) but with increased risk among diabetic patients (OR = 3.69; 95% CI, 2.34–5.82). These risk associations remained statistically significant when the analysis was restricted to whites or after exclusion of recent onset diabetes. No significant main effect of other genes or significant interaction of genotype with other risk factors was observed. The findings show a potential role of HK2 gene, alone or in interaction with diabetes, in modifying the risk of PC. Cancer Prev Res; 4(5); 758–66. ©2011 AACR.
Porcine cartilage transplants in the cynomolgus monkey. III. Transplantation of alpha-galactosidase-treated porcine cartilage.

BACKGROUND Studies on transplantation of porcine meniscus and articular cartilage into monkeys are important for evaluating the possible use of such tissues in humans. In addition, such studies shed light on the chronic xenograft rejection process in primates. Transplantation of porcine cartilage into cynomolgus monkeys for 2 months results in a many-fold increase in anti-Gal activity and in a strong cellular inflammatory response of T lymphocytes and macrophages within the implants. The objective of this study was to determine whether elimination of Galalpha1-3Galbeta1-4GlcNAc-R (alpha-gal epitopes) from the xenograft may alter the immune response and the inflammatory reaction. METHODS Porcine meniscus and articular cartilage specimens were treated with recombinant alpha-galactosidase (100 U/ml), and the absence of alpha-gal epitopes was assessed by the binding of the monoclonal anti-Gal antibody M86. The treated cartilage specimens were transplanted into the suprapatellar pouch of cynomolgus monkeys. The immune response to cartilage was monitored in the serum and the inflammatory reaction was assessed in the xenografts, which were explanted after 2 months. RESULTS Incubation with alpha-galactosidase resulted in complete removal of alpha-gal epitopes from the cartilage. The increase in anti-Gal activity in the transplanted monkeys was marginal. However, most monkeys produced antibodies to antigens specific to porcine cartilage. The inflammatory response within the alpha-galactosidase-treated xenografts was much lower than in nontreated cartilage and the proportion of T lymphocytes within the cellular infiltrates was greatly reduced. CONCLUSIONS Treatment of cartilage xenografts with alpha-galactosidase successfully removes alpha-gal epitopes from porcine cartilage. Transplantation of the treated cartilage results in the production of only anti-porcine cartilage-specific antibodies and a reduced inflammatory response consisting primarily of macrophages infiltrating into the cartilage.
Harnessing Employee Innovation in Internal Crowdsourcing Platforms: Lessons from Allianz UK

Internal crowdsourcing platforms, which enable firms to generate a large pool of ideas and connect employees to large number of colleagues, hold the potential to support employee innovation. Yet, managers face considerable difficulties when it comes to deploying such platforms in a way that generates business value. This article describes the eight years-long evolution of Allianz UK efforts to tap into its employees' ideas to drive innovation as a collective capacity. It identifies the challenges the firm faced with its internal crowdsourcing journey and describes the organizational design mechanisms adopted by leaders to address them. Our analysis reveals the necessity to adopt a configurational perspective among design elements to reinforce value creation. It details the design elements adopted by the firm to harness employee innovation and distills the lessons learned along the way.
R3PUF: A Highly Reliable Memristive Device based Reconfigurable PUF

We present a memristive device based R$ ^3 $PUF construction achieving highly desired PUF properties, which are not offered by most current PUF designs: (1) High reliability, almost 100\% that is crucial for PUF-based cryptographic key generations, significantly reducing, or even eliminating the expensive overhead of on-chip error correction logic and the associated helper on-chip data storage or off-chip storage and transfer. (2) Reconfigurability, while current PUF designs rarely exhibit such an attractive property. We validate our R$ ^3 $PUF via extensive Monte-Carlo simulations in Cadence based on parameters of real devices. The R$ ^3 $PUF is simple, cost-effective and easy to manage compared to other PUF constructions exhibiting high reliability or reconfigurability. None of previous PUF constructions is able to provide both desired high reliability and reconfigurability concurrently.
Common and rare genetic markers of lipid variation in subjects with type 2 diabetes from the ACCORD clinical trial

Background Individuals with type 2 diabetes are at an increased risk of cardiovascular disease. Alterations in circulating lipid levels, total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG) are heritable risk factors for cardiovascular disease. Here we conduct a genome-wide association study (GWAS) of common and rare variants to investigate associations with baseline lipid levels in 7,844 individuals with type 2 diabetes from the ACCORD clinical trial. Methods DNA extracted from stored blood samples from ACCORD participants were genotyped using the Affymetrix Axiom Biobank 1 Genotyping Array. After quality control and genotype imputation, association of common genetic variants (CV), defined as minor allele frequency (MAF) ≥ 3%, with baseline levels of TC, LDL, HDL, and TG was tested using a linear model. Rare variant (RV) associations (MAF < 3%) were conducted using a suite of methods that collapse multiple RV within individual genes. Results Many statistically significant CV (p < 1 × 10−8) replicate findings in large meta-analyses in non-diabetic subjects. RV analyses also confirmed findings in other studies, whereas significant RV associations with CNOT2, HPN-AS1, and SIRPD appear to be novel (q < 0.1). Discussion Here we present findings for the largest GWAS of lipid levels in people with type 2 diabetes to date. We identified 17 statistically significant (p < 1 × 10−8) associations of CV with lipid levels in 11 genes or chromosomal regions, all of which were previously identified in meta-analyses of mostly non-diabetic cohorts. We also identified 13 associations in 11 genes based on RV, several of which represent novel findings.
TV Watcher: Distributed Media Analysis and Correlation

The explosion of available content in broadcast media has created a desperate need for applications and prerequisite system architectures to support automatic capture, filtration, categorization, correlation, and higher level inferencing of streaming data from distributed sources. We present TV Watcher, an archetypical example of such an application. TV Watcher performs usercontrolled correlation of live television feeds and allows the user to automatically navigate through the available channels based on content of interest. We introduce the Symphony architecture for distributed real-time media analysis and delivery to meet the system requirements for applications with such needs. TV Watcher is built on top of the Symphony architecture, and currently uses closed-captioning information to correlate television programming. We present the results of a user study that shows the correlation engine is consistently able to pick significantly useful and relevant content.
Metastability testing at FPGA circuit design using propagation time characterization

This paper describes the measurement method and experimental technique with advanced instrumentation setup for analysing the metastability behavior and performance measurement of flip-flops used in programmable logic devices. In order to demonstrate this testing approach, the results for metastable characteristics parameters of one FPGA digital circuit fabricated commercially in 90 nm CMOS process are presented. The same test methods can also be used for evaluation of timing reliability in digital circuits as well.
The Relationship of Psychological Father Presence, Wife's Personal Qualities and Wife/Family Dysfunction in Families of Missing Fathers.

Findings from this study add strong support to the theoretical proposition by Boss (1975, 1977) that in a family with a physically absent father, a high degree qf Psychological Father Presence relates to wife dysfunction and is a significant predictor of Wife as well as Family Dysfunction. There is no support for the premise that the wife's androgynous qualities allow her to close-out her missing husband more easily
A biomimetic reactive navigation system using the optical flow for a rotary-wing UAV in urban environment

Flying insects, such as houseflies or bees, have sensory-motor abilities that still outperform those of UAV. Beyond their flying manoeuvrability, they benefit from a reactive navigation system that enables them to wander in cluttered environments thanks to visual information. Their nervous system, relatively simple compared to that of other animals, exploits this information to efficiently extract the optical flow, which informs them about the distances of perceived objects. A navigation strategy that exploits the optical flow to avoid collisions with both lateral and frontal obstacles has been used here to control a realistic simulated rotary-wing UAV in a 3D urban textured environment.
What Do Feminists Believe?

When a woman says “I am a feminist” what does she mean? What do other people think she means? We asked 71 women to complete the Feminist Perspectives Scale (Henley, Meng, O'Brien, McCarthy, & Sockloskie, 1998) from their own perspective and from the perspective of a “typical feminist. ” Women who self-identified as feminists had stronger beliefs than those who did not on all feminist perspectives except cultural feminism. Both groups believed that a typical feminist held stronger radical, socialist, and cultural feminist beliefs than they themselves did, although the discrepancies were greater for nonfeminists. Nonfeminists viewed a typical feminist as endorsing stronger cultural feminist views than did feminists. Our results indicate that feminist self-identity is related to endorsement of feminist ideologies, and that both feminists and nonfeminists think that a typical feminist is more extreme than they are. The results also suggest that cultural feminism is a contested ideology; it is not endorsed by feminists, but is ascribed to them by nonfeminists.
3D-QSAR Studies on Barbituric Acid Derivatives as Urease Inhibitors and the Effect of Charges on the Quality of a Model

Urease enzyme (EC 3.5.1.5) has been determined as a virulence factor in pathogenic microorganisms that are accountable for the development of different diseases in humans and animals. In continuance of our earlier study on the helicobacter pylori urease inhibition by barbituric acid derivatives, 3D-QSAR (three dimensional quantitative structural activity relationship) advance studies were performed by Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) methods. Different partial charges were calculated to examine their consequences on the predictive ability of the developed models. The finest developed model for CoMFA and CoMSIA were achieved by using MMFF94 charges. The developed CoMFA model gives significant results with cross-validation (q2) value of 0.597 and correlation coefficients (r2) of 0.897. Moreover, five different fields i.e., steric, electrostatic, and hydrophobic, H-bond acceptor and H-bond donors were used to produce a CoMSIA model, with q2 and r2 of 0.602 and 0.98, respectively. The generated models were further validated by using an external test set. Both models display good predictive power with r2pred ≥ 0.8. The analysis of obtained CoMFA and CoMSIA contour maps provided detailed insight for the promising modification of the barbituric acid derivatives with an enhanced biological activity.
Role of Polo-like Kinase CDC5 in Programming Meiosis I Chromosome Segregation

Meiosis is a specialized cell division in which two chromosome segregation phases follow a single DNA replication phase. The budding yeast Polo-like kinase Cdc5 was found to be instrumental in establishing the meiosis I chromosome segregation program. Cdc5 was required to phosphorylate and remove meiotic cohesin from chromosomes. Furthermore, in the absence of CDC5 kinetochores were bioriented during meiosis I, and Mam1, a protein essential for coorientation, failed to associate with kinetochores. Thus, sister-kinetochore coorientation and chromosome segregation during meiosis I are coupled through their dependence on CDC5.
Together, yet still not equal? Sex integration in equestrian sport

Sex segregation is a core organising principle of most modern sports and is a key element in the marginalisation and subordination of girls and women in sport and beyond. In this article I explore the only Olympic-level sport which is not organised around sex segregation – equestrian sport – in order to consider the implications of sex integration for female participants. I draw on a study conducted on elite riders that found that although sex integration in equestrian sport does not lead to female participants being excluded from high-level competition, men continue to perform disproportionately well. This suggests that although sex integration may be an important step towards breaking down gender hierarchies in sport, without accompanying wider changes in gender norms and expectations, sex integration alone will not be enough to achieve greater gender equality in equestrian sport.
Accelerated time experience after left frontal cortex lesion

Abstract We report a patient, BW, with an accelerated time experience as a result of a glioblastoma in his left superior prefrontal cortex. He experienced external events as seeming to occur at a much faster rate than before the lesion, but he showed normal awareness of time, place, and identity. He displayed behavioral slowness, some aphasia, right hemispatial neglect, and other neuropsychological problems typical of left frontal damage. When asked to produce 60 s durations, BWs mean production was extremely long (286.0 s). This finding is consistent with the notion that subjective duration had decreased relative to objective duration. Several explanations for the findings are discussed, including the possibility that the rate of an internal pacemaker was greatly slowed.
Multiple description coding using rotated permutation codes

Summary form only given. This paper proposes a technique that would address the problem of designing multiple description source codes for J channels. Instead of implementing optimal combining we propose to simply average the decoded output of the individual channels and then adjust the length of the resulting vector based on a theoretical analysis valid for permutation codes. The choice of using permutation codes comes from the fact that their low complexity makes high dimensional vector quantization possible, i.e. large TV's, and our simulations have indicated that the random generation of rotation matrices works well when the dimension is high. For low dimensions, different outcomes of the generated rotation matrices seem to yield quite different performance, meaning that the random design may not be as appropriate for this case. Hence, any vector quantization scheme able to perform quantization in high dimensions could potentially replace the permutation coding in the proposed scheme. We also extend the method to use a fraction rho of the rate R to quantize the quantization error of the decoded data, when all descriptors are received, rather then using the whole rate to quantize the individual descriptors. This improves the performance when receiving all the descriptors at the cost of a decreased performance when some of the descriptors are lost. Varying rho therefore produces different operation points in the tradeoff between side and central distortion. The main advantages of the proposed method are its relatively low complexity and its ability to easily implement any number of descriptions
Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians.

We determined the common polymorphism of apolipoprotein E (E2, E3, and E4), apolipoprotein B Xba I polymorphism, and apolipoprotein C-III Sst I polymorphism in almost all Finnish centenarians alive in 1991 (n = 179/185). Plasma lipid and lipoprotein levels in different apolipoprotein genotypes were also measured. In comparison with younger Finnish populations studied previously, the frequency of the apolipoprotein E epsilon 2 allele was almost twice as high (7.0% versus 4.1%; P < .05) and that of the epsilon 4 allele only approximately one third as high (8.4% versus 22.7%; P < .001) in the centenarians. Plasma cholesterol and high-density lipoprotein cholesterol levels tended to be lowest in the group with the epsilon 2 allele (4.33 mmol/L and 1.41 mmol/L, respectively), intermediate in those with the epsilon 3 allele (4.57 mmol/L and 1.48 mmol/L, respectively), and highest in those with the epsilon 4 allele (4.82 mmol/L and 1.60 mmol/L, respectively). The frequencies of the apolipoprotein B X1 and X2 alleles (Xba I restriction site absent or present, respectively) among the centenarians and among the young Finns were not significantly different, whereas the apolipoprotein C-III S2 allele (Sst I restriction site present) occurred more often in the centenarians (frequency, 12.9%) than in the youngest reference population (frequency, 8.8%; P < .05). Centenarians with the apolipoprotein B X2X2 genotype and apolipoprotein E4 phenotype had a higher mean plasma cholesterol level than those with the X1X1 genotype and E2 phenotype (5.24 versus 3.43 mmol/L; P < .05). (ABSTRACT TRUNCATED AT 250 WORDS)
Contrastive Analysis and Feature Selection for Korean Modal Expression in Chinese-korean Machine Translation System

To generate a proper Korean predicate, a natural modal expression is the most important factor for a machine translation (MT) system. Tense, aspect, mood, negation, and voice are the major constituents related to modal expression. The linguistic encoding of a modal expression is quite different between Chinese and Korean in terms of linguistic typology and genealogy. In this paper, a new applicable categorization of Korean modality system viz. tense, aspect, mood, negation, and voice, will be proposed through a contrastive analysis of Chinese and Korean from the viewpoint of a practical MT system. In order to precisely determine the modal expression, effective feature selection frameworks for Chinese are presented with a variety of machine learning methods. As a result, our proposed approach achieved an accuracy of 83.10%.