Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical studies with 5-fluorouracil.

Summary 1.Patients receiving less than 8 mg/kg of 5-fluorouracil given as a single intravenous injection per day for 5 days showed minimal toxic effects. 2.Severe toxicity was not observed with doses of 15 mg/kg/day × 5, provided alkylating agents or deep x-ray and/or radium therapy had not been given previously. 3.The two deaths in this series might have been avoided if stomatitis had been used as a guide for termination of therapy. 4.The effects of 5-fluorouracil toxicity are of relatively short duration once the drug is withdrawn. 5.Tumor regression was noted only in those patients manifesting severe toxicity. 6.Nine patients in the group of 35 receiving what we presently consider adequate therapeutic dosage showed objective regression of neoplasms. 7.Analgesics were no longer required for the relief of pain in the majority of patients following treatment with 5-fluorouracil. 8.Thus far in patients with solid tumors that have responded to repeated courses of 5-fluorouracil therapy, no development of resistance to the drug has been observed. 9.The results obtained in our series of solid neoplasms suggest a continuation and extension of this study.
Kernel-Based Feature Extraction for Automated Gait Classification Using Kinetics Data

The analyzing quantitative kinetics gait data is very important in medical diagnostics as well as in early identification of gait asymmetry. The paper investigated the application of kernel-based technique in kinetic gait data with nonlinear property for gait feature extraction and classification. Its basic idea was that Kernel principal component analysis (KPCA) algorithm was employed to extract gait feature for initiating the training set of support vector machines (SVM) via pre-processing, which SVM with better generalization performance recognized gait patterns. Kinetics gait data of 24 young and 24 elderly participants were analyzed, and the receiver operating characteristic (ROC) plots were adopted to evaluate the generalization performance of gait classifier. The result showed that the proposed approach could map the participantpsilas kinetics gait data structure into a linearly separable space with higher dimension, recognizing gait patterns with 90% accuracy, and has considerable potential for future clinical applications.
Empirical Likelihood in Nonignorable Covariate-Missing Data Problems

Abstract: Missing covariate data occurs often in regression analysis, which frequently arises in the health and social sciences as well as in survey sampling. We study methods for the analysis of a nonignorable covariate-missing data problem in an assumed conditional mean function when some covariates are completely observed but other covariates are missing for some subjects. We adopt the semiparametric perspective of Bartlett et al. (Improving upon the efficiency of complete case analysis when covariates are MNAR. Biostatistics 2014;15:719–30) on regression analyses with nonignorable missing covariates, in which they have introduced the use of two working models, the working probability model of missingness and the working conditional score model. In this paper, we study an empirical likelihood approach to nonignorable covariate-missing data problems with the objective of effectively utilizing the two working models in the analysis of covariate-missing data. We propose a unified approach to constructing a system of unbiased estimating equations, where there are more equations than unknown parameters of interest. One useful feature of these unbiased estimating equations is that they naturally incorporate the incomplete data into the data analysis, making it possible to seek efficient estimation of the parameter of interest even when the working regression function is not specified to be the optimal regression function. We apply the general methodology of empirical likelihood to optimally combine these unbiased estimating equations. We propose three maximum empirical likelihood estimators of the underlying regression parameters and compare their efficiencies with other existing competitors. We present a simulation study to compare the finite-sample performance of various methods with respect to bias, efficiency, and robustness to model misspecification. The proposed empirical likelihood method is also illustrated by an analysis of a data set from the US National Health and Nutrition Examination Survey (NHANES).
Transcriptomic Evidence for the Evolution of Shoot Meristem Function in Sporophyte-Dominant Land Plants through Concerted Selection of Ancestral Gametophytic and Sporophytic Genetic Programs.

Alternation of generations, in which the haploid and diploid stages of the life cycle are each represented by multicellular forms that differ in their morphology, is a deﬁning feature of the land plants (embryophytes). Anciently derived lineages of embryophytes grow predominately in the haploid gametophytic generation from apical cells that give rise to the photosynthetic body of the plant. More recently evolved plant lineages have multicellular shoot apical meristems (SAMs), and photosynthetic shoot development is restricted to the sporophyte generation. The molecular genetic basis for this evolutionary shift from gametophyte-dominant to sporophyte-dominant life cycles remains a major question in the study of land plant evolution. We used laser microdissection and next generation RNA sequencing to address whether angiosperm meristem patterning genes expressed in the sporophytic SAM of Zea mays are expressed in the gametophytic apical cells, or in the determinate sporophytes, of the model bryophytes Marchantia polymorpha and Physcomitrella patens . A wealth of upregulated genes involved in stem cell maintenance and organogenesis are identiﬁed in the maize SAM and in both the gametophytic apical cell and sporophyte of moss, but not in Marchantia . Signiﬁcantly, meiosis-speciﬁc genetic programs are expressed in bryophyte sporophytes, long before the onset of sporogenesis. Our data suggest that this upregulated accumulation of meiotic gene transcripts suppresses indeterminate cell fate in the Physcomitrella sporophyte, and overrides the observed accumulation of meristem patterning genes. A model for the evolution of indeterminate growth in the sporophytic generation through the concerted selection of ancestral meristem gene programs from gametophyte-dominant lineages is proposed. phylogeny that remain untested. This phylogeny is based on data from Qiu et al. (2006). We note that the phylogenetic grouping of the bryophtyes is an active area of research and viewing these data in light of other phylogenetic hypotheses will provide interesting alternative hypotheses to the model presented here.
Cloning of four DNA fragments complementary to human thyroglobulin messenger RNA.

Human thyroglobulin mRNA was isolated from Graves' goitres by size selection of total poly(A)-rich RNA in a sucrose gradient. It sedimented at 33 S, as in other mammalian species, and showed a single component of approximately 8500 bases by gel electrophoresis. cDNA was synthesized from the 33-S RNA by using reverse transcriptase in the presence of human placenta ribonuclease inhibitor and in conditions allowing the formation of long transcripts. The latter was made double-stranded using reverse transcriptase and blunt-ended with nuclease S1. After tailing with dCTP and terminal transferase, the double-stranded cDNA was annealed to pBR322 DNA that had been cleaved at the endonuclease PstI site and tailed with dGTP. The resulting plasmids were used to transform Escherichia coli C600 cells and four cloned recombinants were selected. Each plasmid DNA was shown to contain a sequence complementary to human thyroglobulin mRNA by hybridization with a labeled 33-S mRNA, visualization of cDNA . mRNA hybrids by electron microscopy and filter hybridization selection of mRNA directing the synthesis of immunologically related thyroglobulin peptides in the reticulocyte lysate. The four inserted DNA sequences were 1400 - 1800 base pairs long, two of them showing an homologous sequence of 1100 base pairs. Together, the four cloned DNA fragments represented 63% of the 8500 bases of human thyroglobulin mRNA.
Iodine seed‐ versus wire‐guided localization in breast‐conserving surgery for non‐palpable ductal carcinoma in situ

Breast‐conserving surgery for isolated non‐palpable ductal carcinoma in situ (DCIS) is associated with high rates of incomplete surgical resection in comparison with unifocal invasive breast cancer. Therefore, accurate preoperative localization of the lesion is very important to facilitate adequate resection. Wire‐guided localization (WGL) remains the standard for localization of DCIS. Recently, iodine‐125 seed‐guided localization (I‐125 GL) was introduced as an alternative localization technique. The aim of this study was to compare the efficacy of these localization techniques in the resection of DCIS by breast‐conserving surgery.
Linearization and Control of Series-Series Compensated Inductive Power Transfer System Based on Extended Describing Function Concept

The extended describing function (EDF) is a well-known method for modelling resonant converters due to its high accuracy. However, it requires complex mathematical formulation effort. This paper presents a simplified non-linear mathematical model of series-series (SS) compensated inductive power transfer (IPT) system, considering zero-voltage switching in the inverter. This simplified mathematical model permits the user to derive the small-signal model using the EDF method, with less computational effort, while maintaining the accuracy of an actual physical model. The derived model has been verified using a frequency sweep method in PLECS. The small-signal model has been used to design the voltage loop controller for a SS compensated IPT system. The designed controller was implemented on a 3.6 kW experimental setup, to test its robustness.
The experimental study of long-gap vacuum arc

In this paper, experimental system to measure long-gap vacuum arc characteristics was established. A single-frequency oscillation circuit was applied to provide short-circuit currents, and the contacts were set in a demountable vacuum chamber. The arc mode transition of axial magnetic field electrodes was observed by a high-speed charge coupled device (CCD) video camera while the arc current and arc voltage were recorded. A triggering device was designed and manufactured to ignite the vacuum arc. Three AMF contacts with different structure were designed and manufactured, and they were tested under different gap distance, different current and different diameter of electrode. The magnetic field at contact gap was simulated and analyzed by using 3D finite element software Ansoft. Based on the tests and simulation results, effects of AMF, gap distance and diameter of electrodes on long-gap vacuum arc characteristics were analyzed, and long-gap vacuum arc characteristics were summarized.
Computer aided hearing assessment: towards an automated audiometric tool

La perdida de audicion consiste en una disminucion parcial o total de la capacidad para percibir sonidos que afecta a un amplio rango de poblacion y tiene un impacto negativo en sus actividades diarias. La audiometria tonal liminar es uno de los tests estandard para la evaluacion de la capacidad auditiva. Durante la realizacion de esta evaluacion el audiologo trata paralelamente de identificar pacientes con tiempos de respuesta anormalmente lentos. Esta identificacion es relevante pues podria tratarse de un sintoma asociado a alguna patologia que debiera ser estudiada. El otro objetivo principal es la evaluacion de pacientes con deterioro cognitivo o trastornos graves de comunicacion, puesto que no es posible mantener una interaccion tipica de preguntarespuesta cuando se evalua su audicion. En estos casos, el experto debe centrar su atencion en la deteccion de reacciones gestuales espontaneas al sonido. La subjetividad implicada en la interpretacion de ambos objetivos puede afectar a la clasificacion, introducir imprecisiones, limitar la reproducibilidad y tambien producir un alto grado de inter e intra varibialidad del observador. En este sentido, el desarrollo de un metodo automatizado, objetivo y sistematico para el analisis y clasificacion de los tiempos de respuesta y de las reacciones gestuales al sonido es, por tanto, altamente conveniente, permitiendo un diagnostico homogeneo y relevando a los expertos de esta tediosa tarea. El proposito de esta investigacion es el diseno de un sistema automatico para la evaluacion de las reacciones gestuales y los tiempos de respuesta a traves del analisis de secuencias de video grabadas durante el desarrollo de la prueba audiometrica. Por una parte, los tiempos de respuesta se miden detectando el envio de estimulos y la respuesta positiva del paciente (expresada levantando la mano). Por otra, las reacciones gestuales son identificadas analizando los movimientos de la mirada usando dos aproximaciones diferentes. Las diferentes propuestas automatizadas presentadas ahorran tiempo a los expertos, mejoran la precision y proporcionan resultados objetivos que no se ven afectados por factores subjetivos.
Friction Compensation in Servo Systems Using a Local Control Design Approach

Nonlinearities degrade considerably performances in motion control systems. Nonlinear friction is a major source of many serious problems such as wear, tracking errors and limit cycles. There has been an extensive research activity dealing with the design of compensating techniques. The approaches cited in the litterature can be divided into: free model compensation or model based compensation strategy. In the present work, a dynamic fuzzy modeling approach of a servo system with friction is developed. The main idea is to take advantage of the linear form of the resulting dynamics to design: 1- a friction observer used as a compensating term of friction effects, 2- a stable tracking controller that allows the system to achieve a trajectory involving slow motions and velocity reversal. The proposed control method is relatively simple to design and efficient for the compensation of friction induced errors. The experimental tests on a robot joint control have demonstrated precise motion control and smoother velocity reversal in the presence of significant level of friction.
Neurone analogique robuste et technologies émergentes pour les architectures neuromorphiques

Les recentes evolutions en microelectronique necessitent une attention particuliere lors de la conception d’un circuit. Depuis les noeuds technologiques de quelques dizaines de nanometres, les contraintes de consommation deviennent preponderantes. Pour repondre a ce probleme, les concepteurs se penchent aujourd’hui sur l’utilisation d’architectures multi-coeurs heterogenes incluant des accelerateurs materiels dotes d’une grande efficacite energetique. Le maintien des specifications d’un circuit apparait egalement essentiel a l’heure ou sa fabrication est de plus en plus sujette a la variabilite et aux defauts. Il existe donc un reel besoin pour des accelerateurs robustes. Les architectures neuromorphiques, et notamment les reseaux de neurones a impulsions, offrent une bonne tolerance aux defauts, de part leur parallelisme massif, et une aptitude a executer diverses applications a faible cout energetique. La these defendue se presente sous deux aspects. Le premier consiste en la conception d’un neurone analogique robuste et a son integration dans un accelerateur materiel neuro-inspire a des fins calculatoires. Cet operateur mathematique a basse consommation a ete dimensionne puis dessine en technologie 65 nm. Integre au sein de deux circuits, il a pu etre caracterise dans l’un d’entre eux et ainsi demontrer la faisabilite d’operations mathematiques elementaires. Le second objectif est d’estimer, a plus long terme, l’impact des nouvelles technologies sur le developpement de ce type d’architecture. Ainsi, les axes de recherches suivis ont permis d’etudier un passage vers un noeud technologique tres avance, les opportunites procurees par des Through-Silicon-Vias ou encore, l’utilisation de memoires resistives a changement de phase ou a filament conducteur.
The mating response cascade does not modulate changes in the steady‐state level of target mRNAs through control of mRNA stability

Many extracellular signals trigger changes in gene expression by altering the steady‐state level of target transcripts. This modulation of transcript levels is typically ascribed to changes in transcription of target genes; however, there are numerous examples of changes in mRNA processing and stability that contribute to the overall change in transcript levels following signalling pathway activation. The α‐factor‐stimulated mating pathway in Saccharomyces cerevisiae is a receptor‐operated MAP kinase cascade that results in increased levels of a large number of target mRNA transcripts when stimulated acutely. A previous study identified many of the transcripts modulated in response to α‐factor and argued, based on genetic studies, that the response occurred solely at the level of gene transcription (Roberts et al., 2000). We directly examined whether enhanced mRNA stability contributes to the increase in the steady‐state level of α‐factor target transcripts by exploiting a temperature‐sensitive RNA Polymerase II mutant, a Ste12 transcription factor import mutant, and tet‐regulated synthetic mating factor minigene reporters. Examination of a panel of α‐factor‐responsive transcripts reveals no change in mRNA stability in response to α‐factor stimulation, providing direct evidence that this signal transduction pathway in S. cerevisiae does not function through modulating transcript stability. Copyright © 2009 John Wiley & Sons, Ltd.
NK Cells Are Required for Dendritic Cell–Based Immunotherapy at the Time of Tumor Challenge

Increasing evidence suggests that NK cells act to promote effective T cell–based antitumor responses. Using the B16-OVA melanoma model and an optimized Gram-positive bacteria–dendritic cell (DC) vaccination strategy, we determined that in vivo depletion of NK cells at time of tumor challenge abolished the benefit of DC immunotherapy. The contribution of NK cells to DC immunotherapy was dependent on tumor Ag presentation by DC, suggesting that NK cells act as helper cells to prime or reactivate tumor-specific T cells. The absence of NK cells at tumor challenge resulted in greater attenuation of tumor immunity than observed with selective depletion of either CD4 or CD8 T cell subsets. Although successful DC immunotherapy required IFN-γ, perforin expression was dispensable. Closer examination of the role of NK cells as helper cells in enhancing antitumor responses will reveal new strategies for clinical interventions using DC-based immunotherapy.
The Marriage of Pragmatics and Rhetoric

Etude de l'union entre la pragmatique et la rhetorique rendue possible par les travaux de P. Grice dans le cadre de la philosophie du langage, en general, et dans le contexte de l'echange communicatif entre locuteur et auditeur, en particulier. Examinant la reconstruction de la rhetorique d'Aristote entreprise par C. Perelman et L. Olbrechts-Tyteca dans «The new rhetoric: a treatise on argumentation» (1969), l'A. se propose de reconstruire une rhetorique en tant que theorie cognitive fondee sur l'inference, d'une part, et de remedier a l'absence d'un traitement des preuves par emotion et des preuves par caractere en se referant aux travaux de W. Fortenbaugh, M. Nussbaum et W. Lyons, d'autre part
Feature - NoC emulation: a tool and design flow for MPSoC

Current systems-on-chip (SoC) execute applications that demand extensive parallel processing; thus, the amount of processors, memories and application-specific signal processing cores is rapidly increasing. In these new multi-processor SoCs, (MPSoCs) one of the most critical elements regarding overall efficiency is on-chip interconnections. Network-on-chip (NoC) provides a structured way of realizing interconnections on silicon, and obviate the limitations of bus-based solutions. NoCs can have regular or ad hoc topologies and can be tuned by a large set of parameters. Simulation and functional validation are essential to assess the correctness and performance of MPSoC architectures. We present a flexible hardware-software emulation framework implemented on a FPGA that is specially designed to suitably explore, evaluate and compare a wide range of NoC solutions with a very limited effort. Our experimental results show a speed-up of four orders of magnitude with respect to cycle-accurate HDL simulation, while retaining cycle accuracy and flexibility of software simulators. Finally, we propose a validation flow for MPSoCs based on our flexible NoC emulation framework, which allows designers to explore and optimize a range of solutions, as well as quickly characterize performance figures and identify possible limitations in their on-chip interconnection architectures.
The Prism-Pair: Simple Dispersion Compensation and Spectral Shaping of Ultrashort Pulses

Citation: Shaked Y, Yefet S, Pe’er A (2016) The Prism-Pair: Simple Dispersion Compensation and Spectral Shaping of Ultrashort Pulses. Int J Exp Spectroscopic Tech 1:007 Copyright: © 2016 Shaked Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. *Corresponding author: Avi Pe'er, Physics department and BINA center for nanotechnology, Bar Ilan University, Ramat Gan 52900, Israel, E-mail: avi.peer@biu.ac. il Received: January 27, 2016: Accepted: April 04, 2016: Published: April 07, 2016 VIBGYOR ISSN: 2631-505X
Systematic review of cardiopulmonary exercise testing post stroke: Are we adhering to practice recommendations?

OBJECTIVE To systematically review the use of cardiopulmonary exercise testing in people who have survived a stroke. The following questions are addressed: (i) What are the testing procedures used? (ii) What are the patient, safety and outcomes characteristics in the cardiopulmonary exercise testing procedures? (iii) Which criteria are used to determine maximum oxygen uptake (VO2peak/max) in the cardiopulmonary exercise testing procedures? METHODS Systematic review of studies of cardiopulmonary exercise testing in stroke survivors. PubMed, EMBASE, and CINAHL were searched from inception until January 2014. MeSH headings and keywords used were: oxygen capacity, oxygen consumption, oxygen uptake, peak VO2, max VO2, aerobic fitness, physical fitness, aerobic capacity, physical endurance and stroke. Search and selection were performed independently by 2 reviewers. Sixty studies were scrutinized, including 2,104 stroke survivors. RESULTS Protocols included treadmill (n = 21), bicycle (n = 33), stepper (n = 3) and arm (n = 1) ergometry. Five studies reported 11 adverse events (1%). Secondary outcomes were reported in few studies, which hampered interpretation of the patient's effort, and hence the value of the VO2peak. CONCLUSION Most studies did not adhere, or insufficiently adhered, to the existing cardiopulmonary exercise testing guidelines for exercise testing. Thus, the results of cardiopulmonary exercise testing protocols in stroke patients cannot be compared.