Miracle-dz/UniFAR-FTUs huggingface dataset:
The shortest way to reach nutritional goals is to adopt Mediterranean food choices: evidence from computer-generated personalized diets.

BACKGROUND Dietary guidelines can be derived from dietary patterns known to be healthy such as the traditional Mediterranean diet. They can also be deduced by translating a set of nutrient recommendations into food combinations. However, the latter may vary depending on the decisions made by different expert committees. OBJECTIVE The objective was to compare the effect of removing or adding selected nutrient recommendations on the dietary changes needed to fulfill a whole set of nutrient recommendations. DESIGN For each adult participating in the French INCA dietary survey (Enquête Individuelle et Nationale sur les Consommations Alimentaires) (n = 1171), a nutritionally adequate diet was modeled that simultaneously met a whole set of nutrient goals (proteins, fiber, essential fatty acids, 10 vitamins, 9 minerals, sodium, saturated fatty acids, free sugars) while deviating the least from the observed diet in terms of food content. Eight sets of models were developed according to the inclusion or not of constraints on total fats, total carbohydrates, total MUFAs, and cholesterol. RESULTS Compared with the observed intakes, fulfilling the whole set of nutrient constraints systematically decreased total fats and increased total carbohydrates, even in the absence of specific constraints on those macronutrients. For whichever model used, a strong consistency was observed in the dietary changes needed to fulfill the constraints, and the greatest increases were seen for unsalted nuts, unrefined grains, legumes, fruit, fish and shellfish, and vegetables. CONCLUSION Whether recommendations on total fats, MUFAs, or total carbohydrates are included or not in the definition of overall nutrient adequacy, foods typical of the Mediterranean diet are needed to reach overall nutrient adequacy.
Crucial role of the small GTPase Rac1 in insulin‐stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma

The Rho family GTPase Rac1 has been implicated in the regulation of glucose uptake in myoblast cell lines. However, no evidence for the role of Rac1 has been provided by a mouse model. The purpose of this study is to test the involvement of Rac1 in insulin action in mouse skeletal muscle. Intravenous administration of insulin indeed elicited Rac1 activation in gastrocnemius muscle, suggesting the involvement of Rac1 in this signaling pathway. We then examined whether insulin‐stimulated translocation of the facilitative glucose transporter GLUT4 from its storage sites to the skeletal muscle sarcolemma depends on Rac1. We show that ectopic expression of constitutively activated Rac1, as well as intravenous administration of insulin, caused translocation of GLUT4 to the gastrocnemius muscle sarcolemma, as revealed by immunofluorescent staining of a transiently expressed exofacial epitope‐tagged GLUT4 reporter. Of particular note, insulin‐dependent, but not constitutively activated Rac1‐induced, GLUT4 translocation was markedly suppressed in skeletal muscle‐specific rac1‐knockout mice compared to control mice. Immunogold electron microscopic analysis of endogenous GLUT4 gave similar results. Collectively, we propose a critical role of Rac1 in insulin‐dependent GLUT4 translocation to the skeletal muscle sarcolemma, which has heretofore been predicted solely by cell culture studies. —Ueda, S. , Kitazawa, S. , Ishida, K, Nishikawa, Y. , Matsui, M. , Matsumoto, H. , Aoki, T. , Nozaki, S. , Takeda, T. , Tamori, Y. , Aiba, A. , Kahn, C. R. , Kataoka, T. , Satoh, T. Crucial role of the small GTPase Rac1 in insulinstimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma. FASEB J. 24, 2254–2261 (2010). www.fasebj. org
Intelligent controller for a stand-alone hybrid generation system

This paper aims at the modeling and power flow analysis of a stand-alone hybrid generating system (SAHGS) comprising of wind and photovoltaic systems. The wind driven self-excited induction generator (SEIG), photovoltaic array and other network components are modeled and simulated using Matlab/Simulink. The variable voltage and frequency of a generator is first rectified and controlled by a DC/DC converter before being fed to a common DC bus. The variable output voltage of the photovoltaic module is also controlled by a DC/DC converter. The DC bus collects the total power from the wind and photovoltaic systems and uses it partly to supply the required load demand and partly to charge the battery bank. The individual systems are simulated for varying wind velocities and solar intensities respectively and the results are used to identify the operating modes. A neuro controller is designed to adjust the duty ratios of the choppers and the firing angle of the converter at which the maximum power generation occurs
Effect of meteorological factors on influenza-like illness from 2012 to 2015 in Huludao, a northeastern city in China

Background This study aims to describe the epidemiological patterns of influenza-like illness (ILI) in Huludao, China and seek scientific evidence on the link of ILI activity with weather factors. Methods Surveillance data of ILI cases between January 2012 and December 2015 was collected in Huludao Central Hospital, meteorological data was obtained from the China Meteorological Data Service Center. Generalized additive model (GAM) was used to seek the relationship between the number of ILI cases and the meteorological factors. Multiple Smoothing parameter estimation was made on the basis of Poisson distribution, where the number of weekly ILI cases was treated as response, and the smoothness of weather was treated as covariates. Lag time was determined by the smallest Akaike information criterion (AIC). Smoothing coefficients were estimated for the prediction of the number of ILI cases. Results A total of 29, 622 ILI cases were observed during the study period, with children ILI cases constituted 86.77%. The association between ILI activity and meteorological factors varied across different lag periods. The lag time for average air temperature, maximum air temperature, minimum air temperature, vapor pressure and relative humidity were 2, 2, 1, 1 and 0 weeks, respectively. Average air temperature, maximum air temperature, minimum air temperature, vapor pressure and relative humidity could explain 16.5%, 9.5%, 18.0%, 15.9% and 7.7% of the deviance, respectively. Among the temperature indexes, the minimum temperature played the most important role. The number of ILI cases peaked when minimum temperature was around −13 °C in winter and 18 °C in summer. The number of cases peaked when the relative humidity was equal to 43% and then began to decrease with the increase of relative humidity. When the humidity exceeded 76%, the number of ILI cases began to rise. Conclusions The present study first analyzed the relationship between meteorological factors and ILI cases with special consideration of the length of lag period in Huludao, China. Low air temperature and low relative humidity (cold and dry weather condition) played a considerable role in the epidemic pattern of ILI cases. The trend of ILI activity could be possibly predicted by the variation of meteorological factors.
Novel Mouse Model of Chronic Pseudomonas aeruginosa Lung Infection Mimicking Cystic Fibrosis

ABSTRACT Pseudomonas aeruginosa causes a chronic infection in the lungs of cystic fibrosis (CF) patients by establishing an alginate-containing biofilm. The infection has been studied in several animal models; however, most of the models required artificial embedding of the bacteria. We present here a new pulmonary mouse model without artificial embedding. The model is based on a stable mucoid CF sputum isolate (NH57388A) with hyperproduction of alginate due to a deletion in mucA and functional N-acylhomoserine lactone (AHL)-based quorum-sensing systems. Chronic lung infection could be established in both CF mice (CftrtmlUnc−/−) and BALB/c mice, as reflected by the detection of a high number of P. aeruginosa organisms in the lung homogenates at 7 days postinfection and alginate biofilms, surrounded by polymorphonuclear leukocytes in the alveoli. In comparison, both an AHL-producing nonmucoid revertant (NH57388C) from the mucoid isolate (NH57388A) and a nonmucoid isolate (NH57388B) deficient in AHL were almost cleared from the lungs of the mice. This model, in which P. aeruginosa is protected against the defense system of the lung by alginate, is similar to the clinical situation. Therefore, the mouse model provides an improved method for evaluating the interaction between mucoid P. aeruginosa, the host, and antibacterial therapy.
Mapping of the distribution of oil palm using Landsat 8 data by comparing machine learning and non-machine learning algorithms

Oil palm is one of the major crops in Malaysia; it accounts for 47% of the global palm oil supply. Equatorial climate has provided Malaysia with the potential to produce oil palm biomass, which is one of the major contributors to the local economy. The utilisation of oil palm biomass as a source of renewable energy is one of the effective methods to promote green energy. Therefore, there is a need to have sufficient data related to oil palm biomass such as yield estimation, oil palm distributions, and locations. The aim of this study was to produce a land cover map on the distribution of oil palm plantations on three districts located in Selangor. Landsat 8 images of resolutions 15 x 15 m were used and classified via machine learning and non-machine learning algorithms. In this study, three different classifier algorithms were compared using support vector machines, artificial neural networks, and maximum likelihood classifications in which the values obtained for overall accuracy were 98.96%, 99.39%, and 15.30% respectively. The output showed that machine learning algorithms, support vector machines and artificial neural networks gave rise to high accuracies. Hence, the mapping of oil palm distributions via machine learning algorithm was better than that via non-machine learning algorithm.
A Bridging Interaction Allows Calmodulin to Activate NO Synthase through a Bi-modal Mechanism*

Calmodulin (CaM) activates the nitric-oxide synthases (NOS) by a mechanism that is not completely understood. A recent crystal structure showed that bound CaM engages in a bridging interaction with the NOS FMN subdomain. We investigated its importance in neuronal NOS (nNOS) by mutating the two residues that primarily create the bridging interaction (Arg752 in the FMN subdomain and Glu47 in CaM). Mutations designed to completely destroy the bridging interaction prevented bound CaM from increasing electron flux through the FMN subdomain and diminished the FMN-to-heme electron transfer by 90%, whereas mutations that partly preserve the interaction had intermediate effects. The bridging interaction appeared to control FMN subdomain interactions with both its electron donor (NADPH-FAD subdomain) and electron acceptor (heme domain) partner subdomains in nNOS. We conclude that the Arg752–Glu47 bridging interaction is the main feature that enables CaM to activate nNOS. The mechanism is bi-modal and links a single structural aspect of CaM binding to specific changes in nNOS protein conformational and electron transfer properties that are essential for catalysis.
Human amnion‐derived mesenchymal stem cells are a potential source for uterine stem cell therapy

Abstract. Objectives: Human amnion is an easy‐to‐obtain novel source of human mesenchymal stem cells, which poses little or no ethical dilemmas. We have previously shown that human amnion‐derived mesenchymal (HAM) cells exhibit certain mesenchymal stem cell‐like characteristics with respect to expression of stem cell markers and differentiation potentials. Materials and methods: In this study, we further characterized HAM cells’ potential for in vivo therapeutic application. Results: Flow cytometric analyses of HAM cells show that they express several stem cell‐related cell surface markers, including CD90, CD105, CD59, CD49d, CD44 and HLA‐ABC, but not CD45, CD34, CD31, CD106 or HLA‐DR. HAM cells at the 10th passage showed normal karyotype. More interestingly, the AbdB‐like HOXA genes HOXA9, HOXA10 and HOXA11 that are expressed in the mesenchyme of the developing female reproductive tract and pregnant uteri are also expressed in HAM cells, suggesting similarities between these two mesenchymal cell types. Progesterone receptor is also highly expressed in HAM cells and expression of genes or proteins in HAM cells could be manipulated with the aid of lentivirus technology or cell‐permeable peptides. To test potentials of HAM cells for in vivo application, we introduced enhanced green fluorescence protein (EGFP)‐expressing HAM cells to mice by intrauterine infusion (into uteri) or by intravenous injection (into the circulation). Presence of EGFP‐expressing cells within the uterine mesenchyme after intrauterine infusion or in lungs after intravenous injection was noted within 1–4 weeks. Conclusions: Collectively, these results suggest that HAM cells are a potential source of mesenchymal stem cells with therapeutic potential.
COMMUNITY‐DWELLING NONDISABLED NONAGENARIANS: TWO‐YEAR FOLLOW‐UP: THE NONASANTFELIU STUDY

significantly. To examine whether worse continence was associated with change in cognition or behavioral symptoms, the differences in MMSE and NPI scores between baseline and Week 26 were calculated. Entering these into the logistic regression model together with age, sex, and drug prescribed (n 5 179) identified poorer MMSE (OR 5 1.17, 95% CI 5 1.03–1.34 per point decline) and poorer NPI (OR 5 1.09, 95% CI 5 1.04–1.18 per point worse) as the only significant dependent variables. Cholinesterase inhibitor treatment was associated with significantly worse urinary continence in this sample. There was no significant difference between rivastigmine and donepezil once baseline characteristics were adjusted for. Patients with worse BPSDs were more likely to experience deterioration in continence; age, sex, and cognitive status were not significant predictors. When the course of cognitive and behavioral change was examined, significant associations between worse continence and cognitive and behavioral decline were found. This implies that improved cognition and behavior in patients who respond to cholinesterase inhibitors offsets the potential for worse continence. The incontinence rates for patients taking donepezil in this sample were the same as those found in a Japanese sample. They are higher than the proxy rate of anticholinergic prescriptions of 4% found in the Ontario dementia cohort. The proxy measure probably underestimates incontinence rates, because not all patients with incontinence receive anticholinergic treatments. Ideally, changes in continence should be assessed in future clinical trials of cholinesterase inhibitors. Until such trial data become available, clinicians should advise patients with AD considering cholinesterase inhibitor treatment that there is an approximately 7% risk of precipitating urinary incontinence and that any current incontinence may be significantly worsened. Risk is highest in those with more-severe BPSD, although should the patient respond well to treatment cognitively or behaviorally, the risk is substantially lower.
Organ Donation Attitudes and Practices among African Americans: An Adapted Measurement Instrument

Abstract:This study reports the psychometric properties and correlates of a measure of organ donation attitudes and practices for African Americans. Methods. We surveyed 736 members from 14 alumni chapters of historically African American sororities and fraternities in Michigan. We constructed subscales and compared subscale values with two variables related to donation status: 1) enrollment status in the state donor registry, and 2) intentions for future enrollment. Results. Psychometric analyses indicated our measure tapped four distinct domains of attitudes concerning donation. The four subscales identified—General Benefits, Race Benefits, General Barriers, and Disparity Barriers—had good psychometric properties. For all four scales the more positive the attitudes toward donation held by the respondent, the more likely they were to report having signed up to be an organ donor. Discussion. An understanding of attitudes toward donation may help development of effective culturally sensitive intervention messages targeting the African American community.
Simple frequency-based sensing of viscosity and dielectric properties of a liquid using acoustic resonators

The effects of a finite polarizability of a liquid sample onto the series resonance frequency of a piezoelectric resonator are described within the small-load approximation. It is found that the sample's electrical capacitance (the ratio of surface potential and surface polarization at the crystal surface) enters the motional branch of the equivalent circuit, thereby shifting the series resonance frequency. This effect comes about by piezoelectric stiffening. Using a conventional quartz crystal with small hole in the front electrode and exposing this crystal to a variety of different liquids, we demonstrate that derived equation describes the experiment reasonably well. Electric and dielectric effects are particularly strong for torsional resonators, which operate at a frequency of around 56 kHz. These are in commercial use for determination of the viscosity of engine oils. We propose a simple method to insitu switch the strength of piezoelectric stiffening. The technique is based on a pair of wires around the crystal, which – if connected to each other – shield the environment from the electric field emanating from the crystal. Closing the switch therefore reduces the overall energy the strain-induced electric field, which reduces the effective stiffness of the crystal and, in consequence, the resonance frequency. This simple device allows to separate the viscoelastic parameters from the polarizability. It could, for instance, be used to differentiate between gasoline and water being accidentally admitted to the lubricant reservoir. The instrument requires a single resonator and is based on the determination of two frequency shifts, only.
Name–picture verification as a control measure for object naming: A task analysis and norms for a large set of pictures

The name–picture verification task is widely used in spoken production studies to control for nonlexical differences between picture sets. In this task a word is presented first and followed, after a pause, by a picture. Participants must then make a speeded decision on whether both word and picture refer to the same object. Using regression analyses, we systematically explored the characteristics of this task by assessing the independent contribution of a series of factors that have been found relevant for picture naming in previous studies. We found that, for “match” responses, both visual and conceptual factors played a role, but lexical variables were not significant contributors. No clear pattern emerged from the analysis of “no-match” responses. We interpret these results as validating the use of “match” latencies as control variables in studies or spoken production using picture naming. Norms for match and no-match responses for 396 line drawings taken from Cycowicz, Friedman, Rothstein, and Snodgrass (1997) can be downloaded at: http://language.psy. bris.ac. uk/name-picture_verification. html
Antinuclear antibodies and HLA class II alleles in Jamaican patients with systemic lupus erythematosus.

OBJECTIVE The relationship between human leukocyte antigens class II (HLA) and antinuclear antibodies was investigated in Jamaican patients with Systemic Lupus Erythematosus (SLE). METHODS Samples of blood of 82 patients with SLE and 75 healthy controls were tested for antinuclear antibodies using the fluorescent antinuclear antibody (FANA) test, counterimmunoelectrophoresis (CIEP) and the Crithidia luciliae immunofluorescence test (CL-IFT). A DNA-based HLA typing method was used to determine the frequencies of alleles of HLA-DRB1, DRB3, DRB4 and DRB5 in patients and healthy controls. RESULTS The FANA test was positive in all of the sera from patients with SLE. Anti-dsDNA antibodies were present in 49% (40/82), anti-Sm/RNP 44% (36/82) and anti-Ro/La 43% (35/82) of the sera from SLE patients. The frequency of HLA-DR4 was significantly lower in SLE patients than in healthy controls (2/82, 2% vs 15/75, 20%; RR = 0.12; p = 0.0004; CP = 0.005) but no other HLA-DRB1 SLE associations were found. A positive HLA-DR3 anti-Ro/La antibody association was found in the patients with SLE (9/21, 43% vs 5/55, 9%; odds ratio (OR) = 7.5; CP = 0.01). In contrast, possession of HLA-DR6 was negatively associated with the absence of anti-dsDNA antibodies (9/32, 28% vs 27/44, 61%; OR = 0.2; CP = 0.05). CONCLUSION The HLA-DR6 allele is associated with the absence of antinuclear antibodies and HLA-DR3 with the presence of anti-Ro/La antibodies in Jamaican patients with SLE. However, these results and those of previous studies of Jamaican patients suggest that the HLA-DR3 association with the development of SLE reported in other populations might in fact reflect the association of HLA-DR3 with anti-Ro/La antibodies. Further investigations are needed to determine whether HLA-DRB antinuclear antibody associations define clinical subsets of SLE in Jamaican patients.
Influence of Influence of Eco-friendly Agricultural Specialized Internet Shopping Mall on Continuous Use Intention: Focus on e-servicescape and Consumption Tendency

This study focused on fashion product internet shopping malls, the area of research is to be expanded through research on eco-friendly agricultural specialized internet shopping malls, and the influence of e-servicescape and consumption tendency of customers using eco-friendly agricultural specialized internet shopping malls on emotional response and behavior intention of customers. As the result of analysis, the following implications can be gained. Specifically, in eco-friendly agricultural goods are subject to offline stores, e- servicescape factors such as aesthetic attraction, spatial functionality, safety of payment, and product assortment are very important factors required in continuous use intention to consumers. In conclusion, functions that consumers need must be prepared and convenience of use must be promoted to vitalize eco-friendly agricultural goods are subject to offline stores for positive consumption emotion to create continuous use intention.
Evolved neomycin phosphotransferase from an isolate of Klebsiella pneumoniae

A new aminoglycoside resistance gene (aphA 1‐IA6) confers high‐level resistance to neomycin. The sequence of apA 1‐IAB is closely related to aphA 1 found in the transposons Tn4352, 7n903 and Tn602. For example, aphA 1‐IAB differs from aphA 1–903 at five nucleotides that result in four amino acid replacements. The enzyme encoded by aphA 1‐IAB has a significantly higher turnover number with neomycin, kanamycin and G418 as substrates than does the aphA 1–903 enzyme. A parsimonious phylogenetic tree suggests that aphA 1‐IAB evolved from an ancestral form that is closely related or identical to the aphA 1 found in Tn903. The excess of replacement substitutions over silent substitutions in aphA I‐IAB, as well as its convergence toward aphA 3 from Staphylococcus aureus, is indicative of selective evolution. Our hypothesis to explain these results is that aphA 1‐IAB evolved under the selective pressure of neomycin use in relatively recent times.