Miracle-dz/UniFAR-FTUs huggingface dataset:
Paradoxical Association of Enhanced Cholesterol Efflux With Increased Incident Cardiovascular Risks

Objective—Diminished cholesterol efflux activity of apolipoprotein B (apoB)–depleted serum is associated with prevalent coronary artery disease, but its prognostic value for incident cardiovascular events is unclear. We investigated the relationship of cholesterol efflux activity with both prevalent coronary artery disease and incident development of major adverse cardiovascular events (death, myocardial infarction, or stroke). Approach and Results—Cholesterol efflux activity from free cholesterol–enriched macrophages was measured in 2 case–control cohorts: (1) an angiographic cohort (n=1150) comprising stable subjects undergoing elective diagnostic coronary angiography and (2) an outpatient cohort (n=577). Analysis of media from cholesterol efflux assays revealed that the high-density lipoprotein fraction (1.063<d<1.21) contained only a minority (≈40%) of [14C]cholesterol released, with the majority found within the lipoprotein particle–depleted fraction, where ≈60% was recovered after apolipoprotein A1 immunoprecipitation. Albumin immunoprecipitation recovered another ≈30% of radiolabeled cholesterol within this fraction. Enhanced cholesterol efflux activity from ATP-binding cassette transporter A1–stimulated macrophages was associated with reduced risk of prevalent coronary artery disease in unadjusted models within both cohorts; however, the inverse risk relationship remained significant after adjustment for traditional coronary artery disease risk factors only within the outpatient cohort. Surprisingly, higher cholesterol efflux activity was associated with increase in prospective (3 years) risk of myocardial infarction/stroke (adjusted hazard ratio, 2.19; 95% confidence interval, 1.02–4.74) and major adverse cardiovascular events (adjusted hazard ratio, 1.85; 95% confidence interval, 1.11–3.06). Conclusions—Heightened cholesterol efflux to apoB-depleted serum was paradoxically associated with increased prospective risk for myocardial infarction, stroke, and death. The majority of released radiolabeled cholesterol from macrophages in cholesterol efflux activity assays does not reside within a high-density lipoprotein particle.
Responsive Classroom?: a critique of a social emotional learning program

This paper looks critically at the Responsive Classroom (RC) program, a social/emotional learning program used ubiquitously in elementary schools for teacher and student training, in the US as well as in Australia, the UK, and other parts of Western Europe. The paper examines empirical studies on RC’s efficacy and outcomes, many of which were conducted under the aegis of a single developmental psychology lab and in US schools. The paper critiques the faulty and potentially dangerous assumptions behind these studies, many of which adhere to obsolete ideals about developmentalism and perpetuate a harmful hegemonic positivity. The paper then examines the language and materials published by RC on its Web site, with an eye toward understanding precisely what the curriculum of RC is and what are its potential shortfalls for students and teachers. Finally, the author argues for an incorporation of theory from psychoanalysis and curriculum theory, as well as philosophical critiques of neoliberalism, for evolving a more nuanced view of difficult and emotional behaviors in the classroom. Literary theory is evoked in order to argue for the complexity of human emotion and the danger inherent in glossing over difficult experience. The paper closes with implications for further research into RC and other similar programs.
Sexual Differences in Dental Development and Prediction of Emergence

The dental development of a genetically homogeneous French-Canadian group of children ranging in age from 2.5 to 19 years was evaluated from 5,437 panoramic radiographs by the method of Demirjian et al. 8 The maturity of each mandibular tooth was evaluated individually. For each stage of each tooth, the developmental curves of boys and girls were compared. A common pattern was found for each tooth, namely the chronological similarity -between boys and girls in the early stages of development and the advancement of girls over boys for the later stages. Developmental scores were given to the seven mandibular teeth. Up to five to six years of age, no difference was found in the timing of dental development between boys and girls, in contrast to the older ages where girls were always more developed than boys. When the emergence curve was plotted with developmental curves, a close relation was established between the stage of formation of all teeth and their emergence, hence the predictive value of the use of dental maturity curves in clinics.
Cross‐typic specificity and immunotherapeutic potential of a human HPV16 E7‐specific CTL line

Cervical cancer (CaCx) is strongly associated with human papillomavirus (HPV) infection, particularly HPV types 16 and 18. The constitutive expression of HPV E6 and E7 proteins in CaCx makes them attractive targets for CTL based immunotherapy. However cervical carcinomas may have features, e.g., antigen processing defects, that limit the effectiveness of HPV specific CTL. Furthermore most vaccine development has concentrated on HPV type 16, and it is not clear whether such vaccines could induce CTL able to cross‐react on related oncogenic HPV types, e.g., HPV31 and 52. To investigate these potentially important parameters in vitro, we used a CTL (D4) specific for HPV16 E711–20. D4 was able to kill a variety of HPV16+ CaCx cell lines including those with suspected (CaSki) or known antigen processing defects (C33A), and with low HPV DNA copy number (SiHa). D4 was also able to cross react on a related peptide from HPV52 E7 but not HPV31 E7. Further analysis suggested that D4 cross reactivity against related peptides was influenced both by TCR contact residues and a certain threshold for peptide binding. The HPV cross‐reactivity was confirmed at the whole protein level as D4 was also able to recognize the endogenously processed forms of HPV16 and 52 E7 but not 31 E7. These results suggest that HPV16 E711–20 would be a useful epitope for immunotherapy in both HPV 16 and 52 tumours. Despite this, it is difficult to generate these CTL in response to vaccination, emphasizing the need for definition of novel epitopes and more efficient vaccination strategies. © 2005 Wiley‐Liss, Inc.
Purification of a Rheumatoid Factor.∗

Summary A macroglobulin was purified from sera of individuals with rheumatoid arthritis which agglutinated sensitized sheep erythrocytes and fixed gamma globulin-latex particle suspensions. Tentative evidence for the homogeneity of a preparation was furnished. The isolated macroglobulin is a component of the rheumatoid factor. The latter is a mixture of closely related macroglobulins.
Integrating multiple scientific computing needs via a Private Cloud infrastructure

In a typical scientific computing centre, diverse applications coexist and share a single physical infrastructure. An underlying Private Cloud facility eases the management and maintenance of heterogeneous use cases such as multipurpose or application-specific batch farms, Grid sites catering to different communities, parallel interactive data analysis facilities and others. It allows to dynamically and efficiently allocate resources to any application and to tailor the virtual machines according to the applications' requirements. Furthermore, the maintenance of large deployments of complex and rapidly evolving middleware and application software is eased by the use of virtual images and contextualization techniques; for example, rolling updates can be performed easily and minimizing the downtime. In this contribution we describe the Private Cloud infrastructure at the INFN-Torino Computer Centre, that hosts a full-fledged WLCG Tier-2 site and a dynamically expandable PROOF-based Interactive Analysis Facility for the ALICE experiment at the CERN LHC and several smaller scientific computing applications. The Private Cloud building blocks include the OpenNebula software stack, the GlusterFS filesystem (used in two different configurations for worker- and service-class hypervisors) and the OpenWRT Linux distribution (used for network virtualization). A future integration into a federated higher-level infrastructure is made possible by exposing commonly used APIs like EC2 and by using mainstream contextualization tools like CloudInit.
Sepsis in AIDS patients: clinical, etiological and inflammatory characteristics

Intensive care mortality of HIV‐positive patients has progressively decreased. However, critically ill HIV‐positive patients with sepsis present a worse prognosis. To better understand this condition, we propose a study comparing clinical, etiological and inflammatory data, and the hospital course of HIV‐positive and HIV‐negative patients with severe sepsis or septic shock.
Trapping and Thermal Effects Analysis for AlGaN/GaN HEMTs by Means of TCAD Simulations

The aim of this letter is to gain insights into the thermal effects and trapping phenomena of AlGaN/GaN high electron mobility transistors by means of 2-D numerical simulations. Starting from experimental pulsed measurements, we study not only the gate/drain lag due to trap phenomena, but also the thermal behavior of such transistors. Actually, transient tests are useful both to analyze the self-heating effect and to characterize donor surface traps and acceptor bulk traps.
Articulated hand tracking from single depth images using Gaussian Swarm Filtering

Articulated hand tracking from video sequences is a challenging task which is often addressed in a particle filter framework. As it is difficult to perform dense sampling in a high-dimensional hand state space, the traditional particle filter can't track articulated hand motion well. In this paper, we propose a new algorithm which combines an improved Gaussian particle swarm optimization (Gaussian PSO) with a particle filter and use the new algorithm, termed Gaussian Swarm Filtering, to track articulated hand motion from single depth images obtained by a Kinect sensor. The improved Gaussian PSO is employed to move the particles towards the promising areas in the state space based on the newest observation. By using the depth information as the only input, our method is immune to background and illumination changes. An implementation of the proposed method is developed with OpenSceneGraph (OSG). Experiments based on synthetic data and real image sequences are both performed for evaluation. The results show that the proposed method is accurate and robust for articulated hand motion tracking.
Verbal fluency, Trail Making, and Wisconsin Card Sorting Test performance following right frontal lobe tumor resection

Three commonly used clinical tests of frontal-executive function are verbal fluency, the Trail Making Test, and the Wisconsin Card Sorting Test, but few lesion studies of regional specificity within the frontal lobe (FL) exist for them. We examined 20 patients with right FL tumor resection, and mapped their damage to explore brain–behavior relations with greater precision. Across tests, the patients performed poorly and they also showed a deficit in switching but not clustering in verbal fluency. Within the right FL, however, we found none of the regional differences reported in studies of mixed-etiology FL patients, possibly due to the gradual neural reorganization that can occur with brain tumors. We discuss the importance of etiology in examining brain–behavior relations.
Changing clonal patterns of Salmonella enteritidis in Maryland: evaluation of strains isolated between 1985 and 1990

We examined isolates from 203 sporadic and outbreak-associated Salmonella enteritidis cases occurring in Maryland between 1985 and 1990. Plasmid profiles were determined for all isolates; 52 isolates were phage typed. Ten plasmid profiles were identified. A single profile (consisting of a single ca. 55-kb plasmid) emerged as the predominant profile in Maryland during the study period. This profile (which was closely associated with phage type 8) accounted for 86% of a group of isolates from sporadic cases in 1988 and 1989, compared with 43% of the 1985 isolates. Strains with this profile were identified in four of nine outbreaks, including one of three outbreaks in which eggs were implicated as a vehicle. While plasmid profiles and phage typing appear to provide complementary means of identifying specific strains of S. enteritidis, the emergence of what appears to be a single predominant clone has reduced the discriminant ability of both typing systems. The factors be a single predominant clone has reduced the discriminant ability of both typing systems. The factors contributing to the emergence of this one clone are still not well understood.
Active Platform Security through Intrusion Detection Using Naïve Bayesian Network for Anomaly Detection

Recently Active Networks were proposed as the approach that will enable quick introduction of new services in the current telecommunication infrastructure. This approach allows third party executable codes (proxylet) to be deployed into the network, which creates a big security risk. In this paper we present the application of Bayesian technology in the development of an anomaly detection system for proxylets. This system will be incorporated into our Intrusion Detection System (IDS) that will provide runtime security to ensure active platform integrity is maintained while running third party executable codes.
Generalizations of Dung Frameworks and Their Role in Formal Argumentation

This article provides a short survey of some of the most popular abstract argumentation frameworks available today. The authors present the general idea of abstract argumentation, highlighting the role of abstract frameworks in the argumentation process, and review the original Dung frameworks and their semantics. A discussion of generalizations of these frameworks follows, focusing on structures taking preferences and values into account and approaches in which not only attack but also support relations can be modeled. Finally, the authors review the concept of abstract dialectical frameworks, one of the most general systems for abstract argumentation providing a flexible, principled representation of arbitrary argument relations.
Corpus of Texts Composed by Japanese Elementary School Children and its Application in Linguistics and Sociology

現在共有されている日本人の子供の書き言葉コーパスは非常に少ないが，子供の書き言葉コーパスは，日本語の使用実態の年齢別推移の分析や，子供の言葉に特徴的に現れる言語形式の分析，国語教育・日本語教育への活用など日本語研究での利用はもちろんのこと，認知発達，社会学など，さまざまな分野での応用の可能性がある．そこで本研究では，全国 4,950 校の小学校の Web サイトを調査し，公開されている作文について，各テキストが子供の書いたテキストであることや学年などの情報を確認の上，作文データの収集を行った．収集したテキスト総数は 10,006，語数は 1,234,961 である．本研究では，大人よりも子供の言語使用において豊富で多様な使用が観察されると予想されるオノマトペに着目し，その学年別の使用実態の推移について調査した．その結果，オノマトペの出現率は学年が上がるにつれ減少していくことが確認できた．さらに，社会学的応用例として，子供と父母との関係性について調査し，父母とのやりとりとそれに対する子供の反応との関係性が，母親の場合の方が強いことを示し，本コーパスのさまざまな応用の可能性を示した．
A 130-nm CMOS single-photon avalanche diode

The first implementation of a single photon avalanche diode (SPAD) is reported in 130nm CMOS technology. The SPAD is fabricated as p+/nwell junction with octagonal shape. Premature edge breakdown is prevented through a guard ring of p-well around the p+ anode. The dynamics of the new device are investigated using both active and passive quenching methods. Single photon detection is achieved by sensing the avalanche using a fast comparator. The SPAD exhibits a maximum photon detection probability of 41% and a typical dark count rate of 100kHz at room temperature. Thanks to its timing resolution of 144ps (FWHM), the SPAD can be used in disparate disciplines, including medical imaging, 3D vision, biophotonics, low-light-illumination imaging, etc.
Exploring various orientation measurement approaches applied to a serious game system for functional rehabilitation

Serious games have been established as a complementary tool for conventional rehabilitation. This trend proved to be beneficial for both experts and patients since the first are able to assign and monitor virtual reality games for their patients to be executed at home, and the latter are greatly motivated by the challenges of these games rather than the repeatable and boring rehabilitation movements. In a previous work, we proposed a serious game for lower limb rehabilitation of the musculoskeletal system using the Microsoft KinectTM camera and a virtual environment. However, this system suffers from inaccurate kinematic measurement due to various external sources. Therefore, this paper explores various kinematic measurement technics to improve the accuracy of our system. Six real time orientation measurement algorithms were assessed and compared, using multiple types of sensors. The results obtained showed a better performance for our system. In fact, this study reinforced a clearer view on a low cost, real time portable system to be implemented at home.
Mojim: A Reliable and Highly-Available Non-Volatile Memory System

Next-generation non-volatile memories (NVMs) promise DRAM-like performance, persistence, and high density. They can attach directly to processors to form non-volatile main memory (NVMM) and offer the opportunity to build very low-latency storage systems. These high-performance storage systems would be especially useful in large-scale data center environments where reliability and availability are critical. However, providing reliability and availability to NVMM is challenging, since the latency of data replication can overwhelm the low latency that NVMM should provide. We propose Mojim, a system that provides the reliability and availability that large-scale storage systems require, while preserving the performance of NVMM. Mojim achieves these goals by using a two-tier architecture in which the primary tier contains a mirrored pair of nodes and the secondary tier contains one or more secondary backup nodes with weakly consistent copies of data. Mojim uses highly-optimized replication protocols, software, and networking stacks to minimize replication costs and expose as much of NVMM? s performance as possible. We evaluate Mojim using raw DRAM as a proxy for NVMM and using an industrial NVMM emulation system. We find that Mojim provides replicated NVMM with similar or even better performance than un-replicated NVMM (reducing latency by 27% to 63% and delivering between 0.4 to 2.7X the throughput). We demonstrate that replacing MongoDB's built-in replication system with Mojim improves MongoDB's performance by 3.4 to 4X.
Cardiac Diseases Following Childhood Cancer Treatment: Cohort Study

Background— Cardiac disease (CD) is one of the major side effects of childhood cancer therapy, but until now little has been known about the relationship between the heart radiation dose (HRD) received during childhood and the risk of CD. Methods and Results— The cohort comprised 3162 5-year survivors of childhood cancer. Chemotherapy information was collected and HRD was estimated. There were 347 CDs in 234 patients, 156 of them were rated grade ≥3. Cox and Poisson regression models were used. The cumulative incidence of any type of CD at 40 years of age was 11.0% (95% confidence interval [CI], 9.5–12.7) and 7·4% (95% CI, 6.2–8.9) when only the CDs of grade ≥3 were considered. In comparison with patients who received no anthracycline and either no radiotherapy or an HRD<0·1Gy, the risk was multiplied by 18·4 (95% CI, 7.1–48.0) in patients who had received anthracycline and no radiotherapy or a HRD <0.1Gy, by 60.4 (95% CI, 22.4–163.0) in those who had received no anthracycline and an HRD≥30Gy, and 61.5 (95% CI, 19.6–192.8) in those who had received both anthracycline and an HRD≥30Gy. Conclusions— Survivors of childhood cancers treated with radiotherapy and anthracycline run a high dose-dependent risk of developing CD. CDs develop earlier in patients treated with anthracycline than in those treated without it.
Phenomenology of embodied dreamwork with Puerto Rican women

The author investigated the experience of embodied dreamwork. Participants were eight Puerto Rican women who were chronically ill, of low socioeconomic status, who lived in Boston. The data were analyzed using transcendental phenomenology. Each participant engaged in one embodied dreamwork–unstructured interview session lasting approximately 1.5 hours. In addition, each participant drew a picture of how she felt after the dreamwork interview. This snowball, purposive sample gave detailed information about how they experienced embodied dreamwork. The participants’ statements were grouped into themes: (a) sense of place—environment, surroundings, spatiality; (b) the players—self, others; (c) plot; (d) in the sea of emotions—naming affective states; (e) the body speaks—somatic experience; (f) complexity—multiple affective states; (g) making meaning (atando cabos); (h) visual expressions; (i) self disclosures—desahogo (unburdening); and (j) cultural beliefs—de allá para acá (from there to here). As an expressive therapy, embodied dreamwork is grounded in the mindbody connection. This connection supports the making of meaning from the dreamwork. By being more aware of ambiguities, embodied dreamwork facilitates being less reactive to external cues. Embodied dreamwork may have applications in the treatment of anxiety, depression, bereavement, and trauma. The significance of this research contributes to the fields of psychology, Latino studies, and expressive arts therapies with chronically ill women. By including ethnic-specific studies, this investigation contributes to culturally sensitive mental health care. The study is limited to the experience of the participants
Joint Degradation of Atrazine/Cationic Red X-GRL with Monophenolic Compound to Reduce Fe²+ Input in Fenton Process

The degradation of atrazine, Cationic Red X-GRL in the presence of monophenolic compound (phenol, 4-CP) by Fenton system at a low Fe2+ concentration of 7 mg-L-1 was investigated, compared with that without monophenolic compound. In the absence of monophenolic compound, the degradation of atrazine was very quick at the first 2 min but then almost stopped. However, the degradation of atrazine with monophenolic compound was greatly enhanced. All atrazine was degraded within 10 min, also 4-CP degradation had a good efficiency. The enhancement of atrazine degradation was due to the higher concentration of Fe2+ in the presence of monophenolic compound. The intermediates of monophenolic compound such as hydroquinone and catechol reduced ferric ion quickly and promoted the Fenton reaction. The joint degradation of Cationic Red X-GRL with monophenolic compound also showed a similar result. This result suggested that the joint treatment of the pesticide or dyestuff-contaminated water with monophenolic wastewater to reduce Fe2+ input was feasible.
Declarative PTIME Queries for Relational Databases using Quantifier Elimination

In this paper, we consider the problem of expressing and computing queries on relational deductive databases in a purely declarative query language, called SHQL (Semi-Horn Query Language). Assuming the relational databases in question are ordered, we show that all SHQL queries are computable in PTIME (polynomial time) and the whole class of PTIME queries is expressible in SHQL. Although similar results have been proven for fixpoint languages and extensions to datalog, the claim is that SHQL has the advantage of being purely declarative, where the negation operator is interpreted as classical negation, mixed quantifiers may be used and a query is simply a restricted first-order theory not limited by the rule-based syntactic restrictions associated with logic programs in general. We describe the PTIME algorithm used to compute queries in SHQL which is based in part on quantifier elimination techniques and also consider extending the method to incomplete relational databases using intuitions related to circumscription techniques.