Miracle-dz/UniFAR-FTUs huggingface dataset:
A randomized comparison of home and clinic follow-up visits after early postpartum hospital discharge.

BACKGROUND Recently enacted federal legislation mandates insurance coverage of at least 48 hours of postpartum hospitalization, but most mothers and newborns in the United States will continue to go home before the third postpartum day. National guidelines recommend a follow-up visit on the third or fourth postpartum day, but scant evidence exists about whether home or clinic visits are more effective. METHODS We enrolled 1163 medically and socially low-risk mother-newborn pairs with uncomplicated delivery and randomly assigned them to receive home visits by nurses or pediatric clinic visits by nurse practitioners or physicians on the third or fourth postpartum day. In contrast with the 20-minute pediatric clinic visits, the home visits were longer (median: 70 minutes), included preventive counseling about the home environment, and included a physical examination of the mother. Clinical utilization and costs were studied using computerized databases. Breastfeeding continuation, maternal depressive symptoms, and maternal satisfaction were assessed by means of telephone interviews at 2 weeks' postpartum. RESULTS Comparing the 580 pairs in the home visit group and the 583 pairs in the pediatric clinic visit group, no significant differences occurred in clinical outcomes as measured by maternal or newborn rehospitalization within 10 days postpartum, maternal or newborn urgent clinic visits within 10 days postpartum, or breastfeeding discontinuation or maternal depressive symptoms at the 2-week interview. The same was true for a combined clinical outcome measure indicating whether a mother-newborn pair had any of the above outcomes. In contrast, higher proportions of mothers in the home visit group rated as excellent or very good the preventive advice delivered (80% vs 44%), the provider's skills and abilities (87% vs 63%), the newborn's posthospital care (87% vs 59%), and their own posthospital care (75% vs 47%). On average, a home visit cost $255 and a pediatric clinic visit cost $120. CONCLUSIONS For low-risk mothers and newborns in this integrated health maintenance organization, home visits compared with pediatric clinic visits on the third or fourth postpartum hospital day were more costly, but were associated with equivalent clinical outcomes and markedly higher maternal satisfaction. This study had limited power to identify group differences in rehospitalization, and may not be generalizable to higher-risk populations without comparable access to integrated hospital and outpatient care.
Mechanical loading and injury induce human myotubes to release neutrophil chemoattractants.

The purpose of this study was to 1) test the hypothesis that skeletal muscle cells (myotubes) after mechanical loading and/or injury are a source of soluble factors that promote neutrophil chemotaxis and superoxide anion (O(2)(-). ) production and 2) determine whether mechanical loading and/or injury causes myotubes to release cytokines that are known to influence neutrophil responses [tumor necrosis factor-alpha (TNF-alpha), IL-8, and transforming growth factor-beta1 (TGF-beta1)]. Human myotubes were grown in culture and exposed to either a cyclic strain (0, 5, 10, 20, or 30% strain) or a scrape injury protocol. Protocols of 5, 10, and 20% strain did not cause injury, whereas 30% strain and scrape injury caused a modest and a high degree of injury, respectively. Conditioned media from strained myotubes promoted chemotaxis of human blood neutrophils and primed them for O(2)(-). production in a manner that was dependent on a threshold of strain and independent from injury. Neutrophil chemotaxis, but not priming, progressively increased with higher magnitudes of strain. Conditioned media only from scrape-injured myotubes increased O(2)(-). production from neutrophils. Concentrations of IL-8 and total TGF-beta1 in conditioned media were reduced by mechanical loading, whereas TNF-alpha and active TGF-beta1 concentrations were unaffected. In conclusion, skeletal muscle cells after mechanical loading and injury are an important source of soluble factors that differentially influence neutrophil chemotaxis and the stages of neutrophil-derived reactive oxygen species production. Neutrophil responses elicited by mechanical loading, however, did not parallel changes in the release of IL-8, TGF-beta1, or TNF-alpha from skeletal muscle cells.
Blockade of CTLA-4 Decreases the Generation of Multifunctional Memory CD4+ T Cells In Vivo

CTLA-4 is known as a central inhibitor of T cell responses. It terminates T cell activation and proliferation and induces resistance against activation induced cell death. However, its impact on memory formation of adaptive immune responses is still unknown. In this study, we demonstrate that although anti–CTLA-4 mAb treatment during primary immunization of mice initially enhances the number of IFN-γ–producing CD4+ T cells, it does not affect the size of the memory pool. Interestingly, we find that the CTLA-4 blockade modulates the quality of the memory pool: it decreases the amount of specialized “multifunctional” memory CD4+ T cells coproducing IFN-γ, TNF-α, and IL-2 in response to Ag. The reduction of these cells causes an immense decrease of IFN-γ–producing T cells after in vivo antigenic rechallenge. Chimeric mice expressing CTLA-4–competent and –deficient cells unmask, which these CTLA-4–driven mechanisms are mediated CD4+ T cell nonautonomously. In addition, the depletion of CD25+ T cells prior to the generation of Ag-specific memory cells reveals that the constitutively CTLA-4–expressing natural regulatory T cells determine the quality of memory CD4+ T cells. Taken together, these results indicate that although the inhibitory molecule CTLA-4 damps the primary immune response, its engagement positively regulates the formation of a high-quality memory pool equipped with multifunctional CD4+ T cells capable of mounting a robust response to Ag rechallenge.
Toward Characterization of Craniofacial Biomechanics

Surgical reconstruction of craniofacial deformities has advanced significantly in recent years. However, unlike orthopedic surgery of the appendicular skeleton, the biomechanical characterization of the human craniofacial skeleton (CFS) has yet to be elucidated. Attempts to simplify facial skeletal structure into straightforward mechanical device analogies have been insufficient in delineating craniofacial biomechanics. Advanced computational engineering analysis methods offer the potential to accurately and completely define the internal mechanical environment of the CFS. This study developed a finite element (FE) model in the I-deas 10 FEM software package of a preserved cadaveric human CFS and compared the predictions of this model against in vitro strain measurement of simulated occlusal loading forces from a single masseter muscle. The FE model applied shell element modeling to capture the behavior of the thin cortical bone that may play an important role in stabilizing the facial structures against functional loads. In vitro testing included strain measurements at 12 locations for a total of 16 independent channels with less than 150 N of tensile force applied through the masseter muscle into the zygomatic arch origin at 4 different orientations, with 3 trials of 500 recorded data points for each loading orientation. Linear regression analysis yielded a moderate prediction (r2 = 0.57) between the model and experimentally measured strains. Exclusion of strain comparisons in regions that required greater modeling assumptions greatly improved the correlation (r2 = 0.70). Future validation studies will benefit from improved placement of strain gauges as guided by FE model predicted strain patterns.
Induction of cell death by the BH3‐only Bcl‐2 homolog Nbk/Bik is mediated by an entirely Bax‐dependent mitochondrial pathway

Nbk/Bik (natural born killer/Bcl‐2‐interacting killer) is a tissue‐specific BH3‐only protein whose molecular function is still largely unknown. To investigate the mechanism of Nbk action, we established a single‐ vector adenoviral system based on the Tet‐off conditional expression of Nbk. Upon Nbk expression, only Bax‐positive, but not Bax‐deficient cells were found to undergo apoptosis. Interestingly, Nbk failed to induce apoptosis in the absence of Bax, even despite expression of the related molecule Bak. Re‐expression of Bax restored the sensitivity to Nbk. Similarly, Bax wild‐type HCT116 cells were highly susceptible, whereas HCT116 Bax knock‐out cells remained resistant to Nbk‐induced apoptosis. In Bax‐positive cells, Nbk induced a conformational switch in the Bax N‐terminus coinciding with cytochrome c release, mitochondrial permeability transition and caspase‐9 processing. Immunoprecipitation studies revealed that Nbk interacts with Bcl‐xL and Bcl‐2 but not with Bax. Since, in addition, Nbk did not localize to the mitochondria, our data suggest a model in which Nbk acts as an indirect killer to trigger Bax‐dependent apoptosis, whereas Bak is not sufficient to confer sensitivity to Nbk.
CDK1/cyclin B regulation during oocyte maturation in two closely related lugworm species, Arenicola marina and Arenicola defodiens

The molecular mechanisms underlying oocyte maturation in the annelid polychaetes Arenicola marina and Arenicola defodiens were investigated. In both species, a hitherto unidentified hormone triggers synchronous and rapid transition from prophase to metaphase, a maturation process which can be easily reproduced in vitro. Activation of a roscovitine‐ and olomoucine‐sensitive M‐phase‐specific histone, H1 kinase, occurs during oocyte maturation. Using affinity chromatography on immobilized p9CKShs1, we purified CDK1 and cyclin B from oocyte extracts prepared from both phases and both species. In prophase, CDK1 is present both as an inactive, but Thr161‐phosphorylated monomer, and as an inactive (Tyr15‐phosphorylated) heterodimer with cyclin B. Prophase to metaphase transition is associated with complete tyrosine dephosphorylation of the cyclin B‐associated CDK1, with phosphorylation of cyclin B, and with dramatic activation of the kinase activity of the CDK1/cyclin B complex. We propose that Arenicola oocytes may provide an ideal model system to investigate the acquisition of the ability of oocytes to be fertilized that occurs as oocyte shift from prophase to metaphase, an important physiological event, probably regulated by active CDK1/cyclin B.
Are the Consumption Patterns of Elderly Households Consistent with a Life-Cycle Model?

A life-cycle savings model was tested to analyze consumption patterns of elderly U.S. households, using the 1990 and 1991 BLS Interview Survey of Consumer Expenditures. The model implies substantial, planned decreases in consumption after retirement, regardless of income patterns. The empirical analysis suggests that as the world population ages, total consumption will decrease, as will most categories of consumption.
Understanding the Emergence of New Institutional Logics: A Boundary Story

We contribute to the literature of institutional logics by integrating a complementary view which is of composite boundary. We integrate the physical, social, and mental boundaries that encompass both the material and symbolic aspects of institutions in order to study the institutional change of knowledge – ‘Mode 1 vs. ‘Mode 2’. We identified three strategies that describe the extent to which scientists engage in this new area. Embracing is characterised by a commitment to the emerging area of nanoscience and nanotechnology at every level of boundary. While the second strategy – adjusting – describes a partial commitment, the third and last strategy – dissociating – describes a nonengagement to nanoscience and nanotechnology. We then describe that the formation of a new scientific space must be balanced as even the teams that embraced the change do so by relating their work to existing communities. We show that a powerful actor such as funding agencies cannot trigger institutional change if inner actors are not engaged in reconstructing their social and mental boundaries. 29th European Group for Organizational Studies Colloquium Montreal, Canada, July 4-6, 2013
Is Phoneme Inventory a Good Predictor for Vocal Tract Use in Casual Speech?

The aim of this study is to provide a general overview of the expected articulatory positions in French according to phoneme inventory, phonemes in words and phonemes in conversational speech. Three datasets were analyzed and relative frequencies of articulators and articulatory dimensions are given. The results show that tongue body is used most frequently. Palatal and velar dimensions are the most frequent constriction locations. No strong differences are observed between the three datasets. This suggests that the use of articulators and dimensions is correctly balanced within words and more especially within high frequent words in speech.
POSTER: Security Design Patterns With Good Usability

This poster presents work-in-progress in the field of usable security. The usability of security mechanisms is crucial to avoid unintended misuse of security mechanisms which lowers the security level of a system. It is the goal of the work presented in this poster to identify security design patterns with good usability. Requirements for security design patterns with good usability stem from existing usable security design guidelines. A collection of security usability failures is presented as well as examples of how misuse anti-patterns can be derived from these failures. Misuse cases will be used in future work to identify security design patterns with good usability.
Understanding Corporate Vulnerabilities in Latin America

This paper analyzes the potential risks and vulnerabilities of non-financial corporates in Latin America and Canada. We quantify the impact of company-specific, countryspecific, and global factors in driving corporate spreads. Overall, we found that all these factors play a role in explaining corporate risk. In particular, country specific factors such as exchange rate and sovereign CDS spreads are significantly associated with changes in corporate spreads, underscoring the importance of solid policy frameworks. We also find that global conditions, such as the VIX, are dominant drivers of corporate spreads. In recent years, the adverse effects from deteriorating domestic conditions have been broadly offset by relatively bening global financial conditions. However, a sustained reversal in these conditions would put significant pressure on corporate risk.
Genome Analysis of Pseudomonas aeruginosa Bacteriophage KPP23, Belonging to the Family Siphoviridae

ABSTRACT Bacteriophage (phage) therapy is expected to become an alternative therapy for Pseudomonas aeruginosa infections. P. aeruginosa phage KPP23 is a newly isolated phage belonging to the family Siphoviridae and may be a therapeutic phage candidate. We report its complete genome, which comprises 62,774 bp of double-stranded DNA containing 95 open reading frames.
Spinal antinociceptive effects of the novel NOP receptor agonist PWT2‐nociceptin/orphanin FQ in mice and monkeys

Using an innovative chemical approach, peptide welding technology (PWT), a tetrabranched derivative of nociceptin/orphanin FQ (N/OFQ) has been generated and pharmacologically characterized. Both in vitro and in vivo PWT2‐N/OFQ displayed the same pharmacological profile to the natural ligand. It was more potent and produced longer‐lasting effects. The aim of the present study was to investigate the spinal effects of PWT2‐N/OFQ in nociceptive and neuropathic pain models in mice and non‐human primates.
Guideline-based consultation to prevent anticoagulant-related bleeding. A randomized, controlled trial in a teaching hospital.

OBJECTIVE To test the efficacy of consultation designed to prevent anticoagulant-related bleeding. DESIGN Randomized, controlled trial. SETTING A large teaching hospital. PATIENTS A total of 101 patients at increased (greater than 15%) risk for major, in-hospital bleeding while starting long-term anticoagulant therapy who were identified using a validated prediction rule. INTERVENTIONS Fifty-five patients received usual care under the direction of the attending physician who had initiated anticoagulant therapy. Forty-six patients received guideline-based consultation in addition to usual care. Guideline-based consultation included individualized review of the risks and benefits of anticoagulant therapy and, on the basis of current practice guidelines, recommendations for daily management. MEASUREMENTS The main outcome was in-hospital bleeding, which was classified using a reliable, explicit index. RESULTS Major or minor bleeding occurred in 17 of 55 patients (31%) receiving usual care alone, compared with 6 of 46 patients (13%) receiving consultation in addition to usual care (P = 0.03). The protective efficacy of consultation was 58% (95% CI, 3% to 82%). Consultation was associated with similar reductions in the frequencies of major bleeding (from 13% to 4%) and minor bleeding (from 18% to 9%). Consultative recommendations had an 84% compliance rate and directly affected anticoagulant management: In the consult group, nonsteroidal anti-inflammatory agents were stopped in six patients (13%), and therapeutic ranges were achieved more often for activated partial thromboplastin times (52% compared with 45% in the usual care group, P = 0.08) and for prothrombin times (47% compared with 27% in the usual care group, P less than 0.001). Nearly all housestaff and attending physicians (91%) for patients receiving consultation also reported that consultation improved housestaff learning. The consult group had a somewhat lower rate of thromboembolism in the 90 days after discharge (5% compared with 17%, P = 0.06). Death rates and mean lengths of stay were similar in the two groups. CONCLUSION Guideline-based consultation was associated with reduction in the frequency of anticoagulant-related bleeding in patients at increased risk for major in-hospital bleeding.
Universal Joint Morph-Syntactic Processing: The Open University of Israel’s Submission to The CoNLL 2017 Shared Task

We present the Open University’s submission to the CoNLL 2017 Shared Task on multilingual parsing from raw text to Universal Dependencies. The core of our system is a joint morphological disambiguator and syntactic parser which accepts morphologically analyzed surface tokens as input and returns morphologically disambiguated dependency trees as output. Our parser requires a lattice as input, so we generate morphological analyses of surface tokens using a data-driven morphological analyzer that derives its lexicon from the UD training corpora, and we rely on UDPipe for sentence segmentation and surface-level tokenization. We report our official macro-average LAS is 56.56. Although our model is not as performant as many others, it does not make use of neural networks, therefore we do not rely on word embeddings or any other data source other than the corpora themselves. In addition, we show the utility of a lexicon-backed morphological analyzer for the MRL Modern Hebrew. We use our results on Modern Hebrew to argue that the UD community should define a UD-compatible standard for access to lexical resources, which we argue is crucial for MRLs and low resource languages in particular.
Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men.

AIM Periodontitis (PD) is influenced by genetic as well as lifestyle and socio-economic factors. Epidemiological studies show that men are at greater risk of severe forms of PD, suggesting interplay between sex and genetic factors. We aimed to systematically analyse patients with aggressive periodontitis (AgP) for gene-sex interactions. MATERIALS AND METHODS Three hundred and twenty-nine German AgP cases and 983 controls were genotyped with Affymetrix 500K Arrays and were analysed by logistic regression analysis. The most significant gene-sex interaction was replicated in an independent sample of 382 German/Austrian AgP cases and 489 controls. RESULTS Ten single-nucleotide polymorphisms (SNPs) in strong linkage disequilibrium (r(2) > 0.85) upstream the gene neuropeptide Y (NPY) suggested gene-sex interaction (p < 5 × 10(-5) ). SNP rs198712 showed the strongest association in interaction with sex (p = 5.4 × 10(-6) ) with odds ratios in males and females of 1.63 and 0.69 respectively. In the replication, interaction of sex with rs198712 was verified with p = 0.022 (pooled p = 4.03 × 10(-6) ) and similar genetic effects. Analysis of chromatin elements from ENCODE data revealed tissue-specific transcription at the associated non-coding region. CONCLUSION This study is the first to observe a sexually dimorphic role of alleles at NPY in humans and support previous genome-wide findings of a role of NPY in severe PD.
Cross‐validation of magnetic resonance elastography and ultrasound‐based transient elastography: A preliminary phantom study

To cross‐validate two recent noninvasive elastographic techniques, ultrasound‐based transient elastography (UTE) and magnetic resonance elastography (MRE). As potential alternatives to liver biopsy, UTE and MRE are undergoing clinical investigations for liver fibrosis diagnosis and liver disease management around the world. These two techniques use tissue stiffness as a marker for disease state and it is important to do a cross‐validation study of both elastographic techniques to determine the consistency with which the two techniques can measure the mechanical properties of materials.
Employee Engagement Makes the Quadruple Aim:Connecting Patients and Employees in Relationship-Centred Care

Common approaches to building and measuring employee engagement focus on the connection of the employee to an organization (i.e., the place of work). This study reveals that current conventional approaches to activating employee engagement are often contrived and will fail to have lasting impact on engagement levels. What truly engages people is the work they do with others serving their constituents. Using an approach that combines field research and foresight methods, this study explores new possibilities that shifts focus from what is done today, “employees to work-place,” to a reframing of how we might build and measure employee engagement. This reframing suggests that what is important is what employees do (work task), who they do it with (team/other employees) and who they do it for (constituents) and not about the connection to where they work (i.e., business or work-place). The context of the study is a large regional teaching hospital that may soon move to a shared service model across the region for services like human resources typically the department tasked with building employee engagement. This particular hospital is also a leader on the topic of patient-centred care, which offers a lens to learn from and reveals common structures between what engages employees and how patient-centred care is practiced. This study asks the question; how might healthcare organizations resolve the challenges to full employee engagement in the indeterminate contexts of patient-centred care? Potential answers and insights are offered into these questions. A provocative account is provided of how we might build and measure employee engagement in the future. Key words: employee engagement, patient-centred care, hospital, measurement, workplace, health care, healthcare