Miracle-dz/UniFAR-FTUs huggingface dataset:
PENANAMAN ETIKA LINGKUNGAN MELALUI SEKOLAH PERDULI DAN BERBUDAYA LINGKUNGAN

Pendidikan merupakan salah satu upaya potensial dalam mengatasi krisis lingkungan yang terjadi saat ini dan masa yang akan datang. Pendidikan yang disampaikan dilingkungan sekolah akan lebih efektif menyentuh dan melekat pada diri peserta didik. Penanaman kepedulian terhadap kelestarian sumberdaya alam dan lingkungan dilingkungan sekolah dapat dilakukan melalui proses belajar mengajar yang bermuatan pendidikan lingkungan hidup, penyediaan lingkungan sekolah yang asri, dan ditunjang dengan fasilitas sekolah. Pendidikan lingkungan hidup di lingkungan sekolah merupakan modal dasar bagi pembentukan etika lingkungan pada lintas generasi.
Factors influencing the adoption of e-government in Pakistan

Governments around the world are working continuously in order to improve services for their citizens. However, the success of these initiatives is dependent not only on the government support but also on the citizens' willingness to use these services. To implement e-government successfully, it is important to determine the factors related to its adoption. This paper examines the factors influencing adoption of e-government services by the Pakistani citizens. Factors that have been explored in the extant literature present inadequate understanding of the relationship that exists between ‘adopter characteristics’ and ‘behavioral intention’ to use e-government services. These inadequacies have been identified through a systematic and thorough review of empirical studies and also by conducting expert reviews from the government officials, software engineers and academic researchers to get their perception according to the context of Pakistan. On the basis of thorough review of literature and expert reviews conducted, an integrated conceptual model is developed and proposed by integrating the influential factors which have been highlighted by the various researchers into a single comprehensive model. In this context, this paper describes and tracks in a fruitful way the factors related to the adoption of e-government services and also proposes conceptual model according to the context of Pakistan.
U-Shaped Curves in Development: A PDP Approach

As the articles in this issue attest, U-shaped curves in development have stimulated a wide spectrum of research across disparate task domains and age groups and have provoked a variety of ideas about their origins and theoretical significance. In our view, the ubiquity of the general pattern suggests that U-shaped curves can arise from multiple factors, and that the various viewpoints represented herein may be useful for explaining some aspects of developmental change. In this spirit, we offer an additional way of thinking about such phenomena. Specifically, we suggest that U-shaped curves can arise within a domain-general learning mechanism as it slowly masters a domain characterized by statistical regularities and exceptions. This idea differs from those considered thus far, and may encompass many of the phenomena addressed by other views, three of which we outline briefly here. JOURNAL OF COGNITION AND DEVELOPMENT, 1(5), 137–145 Copyright © 2004, Lawrence Erlbaum Associates, Inc.
The size-change principle for program termination

The "size-change termination" principle for a first-order functional language with well-founded data is: a program terminates on all inputs if every infinite call sequence (following program control flow) would cause an infinite descent in some data values.Size-change analysis is based only on local approximations to parameter size changes derivable from program syntax. The set of infinite call sequences that follow program flow and can be recognized as causing infinite descent is an ω-regular set, representable by a Büchi automaton. Algorithms for such automata can be used to decide size-change termination. We also give a direct algorithm operating on "size-change graphs" (without the passage to automata). Compared to other results in the literature, termination analysis based on the size-change principle is surprisingly simple and general: lexical orders (also called lexicographic orders), indirect function calls and permuted arguments (descent that is not in-situ) are all handled automatically and without special treatment, with no need for manually supplied argument orders, or theorem-proving methods not certain to terminate at analysis time.We establish the problem's intrinsic complexity. This turns out to be surprisingly high, complete for PSPACE, in spite of the simplicity of the principle. PSPACE hardness is proved by a reduction from Boolean program termination. An ineresting consequence: the same hardness result applies to many other analyses found in the termination and quasitermination literature.
Compartmentalization of Aquaporins in the Human Intestine

Improper localization of water channel proteins called aquaporins (AQP) induce mucosal injury which is implicated in Crohn’s disease and ulcerative colitis. The amino acid sequences of AQP3 and AQP10 are 79% similar and belong to the mammalian aquaglyceroporin subfamily. AQP10 is localized on the apical compartment of the intestinal epithelium called the glycocalyx while AQP3 is selectively targeted to the basolateral membrane. Despite the high sequence similarity and evolutionary relatedness, the molecular mechanism involved in the polarity, selective targeting and function of AQP3 and AQP10 in the intestine is largely unknown. Our hypothesis is that the differential polarity and selective targeting of AQP3 and AQP10 in the intestinal epithelial cells is influenced by amino acid signal motifs. We performed sequence and structural alignments to determine differences in signals for localization and post-translational glycosylation. The basolateral sorting motif “YRLL” is present in AQP3 but absent in AQP10; while N-glycosylation signals are present in AQP10 but absent in AQP3. Furthermore, the C-terminal region of AQP3 is longer compared to AQP10. The sequence and structural differences between AQP3 and AQP10 provide insights into the differential compartmentalization and function of these two aquaporins commonly expressed in human intestines.
Toll-9 activates antimicrobial defense scientific report RESULTS Toll proteins in the activation of antimicrobial peptide genes

The Toll family of transmembrane proteins participates in signaling infection during the innate immune response. We analyzed the nine Drosophila Toll proteins and found that wild-type Toll-9 behaves similar to gain-of-function Toll-1. Toll-9 activates strongly the expression of drosomycin, and utilizes similar signaling components to Toll-1 in activating the antifungal gene. The predicted protein sequence of Toll-9 contains a tyrosine residue in place of a conserved cysteine, and this residue switch is critical for the high activity of Toll-9. The Toll-9 gene is expressed in adult and larval stages prior to microbial challenge, and the expression correlates with the high constitutive level of drosomycin mRNA in the animals. The results suggest that Toll-9 is a constitutively active protein, and implies its novel function in protecting the host by maintaining a substantial level of antimicrobial gene products to ward off the continuous challenge of microorganisms.
Associating words to visually recognized objects ∗

Using associative memories and sparse distributed representations we have developed a system that can learn to associate words with objects, properties like colors, and actions. This system is used in a robotics context to enable a robot to respond to spoken commands like ”bot show plum” or ”bot put apple to yellow cup”. The scenario for this is a robot close to one or two tables on which there are certain kinds of fruit and/or other simple objects. We can demonstrate part of this scenario where the task is to find certain fruits in a complex visual scene according to spoken or typed commands. This involves parsing and understanding of simple sentences and relating the nouns to concrete objects sensed by the camera and recognized by a neural network from the visual
HEPATIC FUNCTION AND NON-INVASIVE HEPATOSPLANCHNIC MONITORING IN PATIENTS WITH ABDOMINAL HYPERTENSION

Abstract A better understanding of intra-abdominal hypertension with relation to the liver is vital to the management of all forms of liver pathophysiology. Supporting good hepatic function within the critically ill patient is important not only in maintaining synthetic function, but also in avoiding the multi-organ complications of liver dysfunction. The resulting reduction in hepato-splanchnic blood flow (HSBF) observed with increasing intra-abdominal pressure has been clearly documented and seen to be exaggerated in animals with established liver disease. Unfortunately the tools required to measure this, remain difficult to apply routinely in the clinical setting and as such goal directed therapy to specifically improve the hepatosplanchnic circulation remains elusive. Given the documented effects of IAP on HSBF and the relatively high incidence of intra-abdominal hypertension and the abdominal compartment syndrome within “liver patients” as a whole, close attention to IAP and timely correction by appropriate medical or surgical means would appear to be essential.
The materiality of virtual war: Post-Traumatic Stress Disorder and the disabling effects of imperialism

A slew of recent news coverage has reported favorably on the use of virtual reality video games as a treatment for post-traumatic stress disorder (PTSD) in US soldiers returning from Iraq and Afghanistan. Drawing on critical disability studies work, this paper argues that such depictions (re)produce a depoliticized framework for understanding PTSD that champions medico-technological interventions and hinders broader social and political activism by taking for granted and normalizing conditions of perpetual war. Through an analysis of medical research and media portrayals extolling such technologies, this paper unravels the contradictory logic in these celebratory depictions to condemn imperialism, problematize the use of virtual reality for PTSD treatment, and ultimately call for anti-imperialist disability studies scholarship and disability activism.
A Group Signature Scheme Based on an RSA-Variant

The concept of group signatures allows a group member to sign messages anonymously on behalf of the group. However, in the case of a dispute, the identity of a signature’s originator can be revealed by a designated entity. In this paper we propose a new group signature scheme that is well suited for large groups, i.e., the length of the group’s public key and of signatures do not depend on the size of the group. Our scheme is based on a variation of the RSA problem called strong RSA assumption. It is also more efficient than previous ones satisfying these requirements.
Effect of propionate toxicity on methanogen-enriched sludge, Methanobrevibacter smithii, and Methanospirillum hungatii at different pH values

The effect of propionate toxicity at different pH values (6.5, 7.0, and 8.0) on methanogen-enriched sludge. Methanobrevibacter smithii, and Methanospirillum hungatii was studied. Organisms were grown in Balch medium 3 in Hungate tubes, and toxicity was characterized by a decrease in production of methane and in bacterial numbers. Propionate inhibited bacterial growth and cumulative methane production at concentrations as low as 20 mM. In the absence of propionate, the methanogen-enriched sludge and M. smithii showed better cumulative methane production at pH 6.5 and 7.0 than at pH 8.0. However, in the presence of propionate, these organisms showed better cumulative methane production at pH 8.0. M. hungatii differed in its behavior; the best values of cumulative methane production for this organism occurred at pH 7.0. Bacterial numbers reflected the microbial response to the presence of propionate. The highest counts of methanogenic bacteria were observed at pH 6.5 and 8.0. The numbers of methanogens were affected by the presence of propionate even at concentrations as low as 20 or 30 mM; at propionate concentrations above 80 mM, the methanogen count was affected by at least 2 orders of magnitude. Upon comparison of the responses of the pure cultures and the methanogen-enriched sludge to increasing propionate concentrations, it was found that the sensitivity of the pure cultures was similar to that of the methanogens in the sludge.
Role of the K101E Substitution in HIV-1 Reverse Transcriptase in Resistance to Rilpivirine and Other Nonnucleoside Reverse Transcriptase Inhibitors

ABSTRACT Resistance to the recently approved nonnucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) commonly involves substitutions at positions E138K and K101E in HIV-1 reverse transcriptase (RT), together with an M184I substitution that is associated with resistance to coutilized emtricitabine (FTC). Previous biochemical and virological studies have shown that compensatory interactions between substitutions E138K and M184I can restore enzyme processivity and the viral replication capacity. Structural modeling studies have also shown that disruption of the salt bridge between K101 and E138 can affect RPV binding. The current study was designed to investigate the impact of K101E, alone or in combination with E138K and/or M184I, on drug susceptibility, viral replication capacity, and enzyme function. We show here that K101E can be selected in cell culture by the NNRTIs etravirine (ETR), efavirenz (EFV), and dapivirine (DPV) as well as by RPV. Recombinant RT enzymes and viruses containing K101E, but not E138K, were highly resistant to nevirapine (NVP) and delavirdine (DLV) as well as ETR and RPV, but not EFV. The addition of K101E to E138K slightly enhanced ETR and RPV resistance compared to that obtained with E138K alone but restored susceptibility to NVP and DLV. The K101E substitution can compensate for deficits in viral replication capacity and enzyme processivity associated with M184I, while M184I can compensate for the diminished efficiency of DNA polymerization associated with K101E. The coexistence of K101E and E138K does not impair either viral replication or enzyme fitness. We conclude that K101E can play a significant role in resistance to RPV.
Chronotype and Body Composition in Bipolar Disorder

We explored whether obesity in patients with bipolar disorder is associated with their chronotype. A group of 29 patients with bipolar I disorder, not currently experiencing an affective episode, were assessed for total body fat, mood symptoms, and self-reported circadian chronotype and sleep quality. Chronotype explained 19% of the variance in body fat, after age, sex, mood state, and sleep quality were accounted for. This association suggested that evening chronotype patients have a higher percentage of total body fat. Evening chronotype could be a proxy for as yet unknown specific causes of the high rate of obesity and obesity-related diseases in bipolar disorder.
Bioinformatics Original Paper a Mixture Model with Random-effects Components for Clustering Correlated Gene-expression Profiles

Motivation: The clustering of gene profiles across some experimental conditions of interest contributes significantly to the elucidation of unknown gene function, the validation of gene discoveries and the interpretation of biological processes. However, this clustering problem is not straightforward as the profiles of the genes are not all independently distributed and the expression levels may have been obtained from an experimental design involving replicated arrays. Ignoring the dependence between the gene profiles and the structure of the replicated data can result in important sources of variability in the experiments being overlooked in the analysis, with the consequent possibility of misleading inferences being made. We propose a random-effects model that provides a unified approach to the clustering of genes with correlated expression levels measured in a wide variety of experimental situations. Our model is an extension of the normal mixture model to account for the correlations between the gene profiles and to enable covariate information to be incorporated into the clustering process. Hence the model is applicable to longitudinal studies with or without replication, for example, time-course experiments by using time as a covariate, and to cross-sectional experiments by using categorical covariates to represent the different experimental classes. Results: We show that our random-effects model can be fitted by maximum likelihood via the EM algorithm for which the E(expectation) and M(maximization) steps can be implemented in closed form. Hence our model can be fitted deterministically without the need for time-consuming Monte Carlo approximations. The effectiveness of our model-based procedure for the clustering of correlated gene profiles is demonstrated on three real datasets, representing typical microarray experimental designs, covering time-course, repeated-measurement and cross-sectional data. In these examples, relevant clusters of the genes are obtained, which are supported by existing gene-function annotation. A synthetic dataset is considered too. Availability: A Fortran program blue called EMMIX-WIRE (EM-based MIXture analysis WIth Random Effects) is available on request from the corresponding author. Colour versions of Figures 1 and 2 are available as Supplementary material on Bioinformatics online.
Educating Software Engineering Managers

The term, "Software Engineering," has been in use for more than 30 years. In that time, the software community has undergone many changes including the introduction of new programming languages, new analysis and design methods and more advanced, easier to use development environments. Even with all these improvements, software continues to be a source of problems and increased risk for most corporations. If the "software problem" were truly of a technical nature, the problems (e.g. late delivery, cost overruns, low quality) would have been largely solved. More recently, the source of these problems has been attributed to the people who direct software development and maintenance efforts - the Software Engineering Manager. This paper examines the nature of Software Engineers, the skills needed to effectively manage them, presents a method for solving most intractable problems associated with managing Software Engineers and discusses the educational issues associated with training effective Software Engineering Managers.
Clinical diagnoses in young offspring from eastern Québec multigenerational families densely affected by schizophrenia or bipolar disorder

Objective: The follow‐up since 1989 of a large sample of multigenerational families of eastern Québec that are densely affected by schizophrenia (SZ) or bipolar disorder (BP) has permitted to look at the rates of DSM diagnoses in the young offspring of a SZ parent (HRSZ) and of a BP parent (HRBP) who had an extremely loaded family history.
A Current Flow Model for m-Level Diode-Clamped Multilevel Converters

Multilevel converters have gained much attention in recent years since they have been a key technology of power electronics to reach the high power ratings required by many applications. Some topological limitations such as DC side voltage balancing, however, have hindered the use of these converters. One of the steps required to solve these problems is the modeling of such complicated topologies to acquire better and deeper insight into the converter structures that consequently paves the way to design new control systems and strategies. This paper presents novel modeling and analysis approach for m-level diode-clamped multilevel converters. Independent of the modulation strategy, the developed current flow model facilitates the study of the dynamic performance of the converter. Simulation results are also provided to validate the proposed models in special cases for 5-level and 6-level diode clamped multilevel converters. Eventually, utilizing the proposed current flow model, it is proved that the traditional SPWM techniques fail to balance the DC-link capacitor voltages
Antioxidative effects of 7‐hydroxy‐3‐methoxy‐cadalene extracted from Zelkova serrata on 4‐(methylinitros amino)‐1‐(3‐pyridyl)‐1‐butanone‐induced oxidative stress in A/J mice

Effects of 7‐hydroxy‐3‐methoxy‐cadalene (cadalene) extracted from Zelkova serrata on 4‐(methylinitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK)‐induced oxidative stress were examined using A/J mice. NNK (65 µg/ml water) was orally administered to 20 mice for 7 weeks, followed by free feeding of a commercial diet, not containing cadalene, for 2 weeks. The control group was maintained without NNK and cadalene administration, and treatment groups with NNK and cadalene (6.25, 25, 100 mg/kg feed) feeding for 25 weeks. The glutathione concentration of cadalene‐treated (65 µg/ml water) group was signiﬁcantly higher than that of the group treated only with NNK (p < 0.05). The results of our study strongly indicate that cadalene exerts antioxidative effect on NNK‐induced lung tumorigenesis in A/J mice. Copyright © 2004 John Wiley & Sons, Ltd.
The bop2-1 mutation reveals radial asymmetry in the inner dynein arm region of Chlamydomonas reinhardtii

Strains of Chlamydomonas reinhardtii with a mutant allele at the BOP2 locus swim slowly and have an abnormal flagellar waveform similar to previously identified strains with defects in the inner arm region. Double mutant strains with the bop2-1 allele and any of 17 different mutations that affect the dynein arm region swim more slowly than either parent, which suggests that the bop2-1 mutation does not affect solely the outer dynein arms, the I1 or ida4 inner dynein arms, or the dynein regulatory complex. Flagellar axonemes isolated from bop2-1 cells are missing a phosphorylated polypeptide of 152 kD. Electron microscopic analysis shows that bop2-1 axonemes are missing density in the inner dynein arm region. Surprisingly, two populations of images were observed in longitudinal sections of axonemes from the bop2-1 strain. In the 10 longitudinal axonemes examined, a portion of the dynein regulatory complex and a newly identified structure, the projection, are affected. In five of these 10 longitudinal axonemes examined, two lobes of the ida4 inner arm are also missing. By examining the cross-sectional images of wild-type and bop2-1 axonemes at each outer doublet position around the axoneme, we have determined that the bop2-1 mutation affects the assembly of inner arm region components in a doublet specific manner. Doublets 5, 6, and 8 have the most severe deficiency, doublet 9 has an intermediate phenotype, and doublets 2, 3, 4, and 7 have the least severe phenotype. The bop2-1 mutation provides the first evidence of radial asymmetry in the inner dynein arm region.
No-reference Harmony-Guided Quality Assessment

Color harmony of simple color patterns has been widely studied for color design. Rules defined then by psychological experiments have been applied to derive image aesthetic scores, or to re-colorize pictures. But what is harmonious or not in an image? What can the human eye perceive disharmonious? Extensive research has been done in the context of quality assessment to define what is visible or not in images and videos. Techniques based on human visual system models use signal masking to define visibility thresholds. Based on results in both fields, we present a harmony quality assessment method to assess what is harmonious or not in an image. Color rules are used to detect what part of images are disharmonious, and visual masking is applied to estimate to what extent an image area can be perceived disharmonious. The output perceptual harmony quality map and scores can be used in a photo editing framework to guide the user getting the best artistic effects. Results show that the harmony maps reflect what a user perceives and that the score is correlated to the artistic intent.