Miracle-dz/UniFAR-FTUs huggingface dataset:
MAGIC observations and multifrequency properties of the flat spectrum radio quasar 3C 279 in 2011

Aims. We study the multifrequency emission and spectral properties of the quasar 3C 279 aimed at identifying the radiation processes taking place in the source. Methods. We observed 3C 279 in very-high-energy (VHE, E> 100 GeV) -rays, with the MAGIC telescopes during 2011, for the first ti me in stereoscopic mode. We combined these measurements with observations at other energy bands: in high-energy (HE, E > 100 MeV) -rays from Fermi-LAT; in X-rays from RXTE; in the optical from the KVA telescope; and in the radio at 43 GHz, 37 GHz, and 15 GHz from the VLBA, Metsahovi, and OVRO radio telescopes - along with optical polarisation measurements from the KVA and Liverpool telescopes. We examined the corresponding light curves and broadband spectral energy distribution and we compared the multifrequency properties of 3C 279 at the epoch of the MAGIC observations with those inferred from historical observations. Results. During the MAGIC observations (2011 February 8 to April 11) 3C 279 was in a low state in optical, X-ray, and -rays. The MAGIC observations did not yield a significant detection. The deri ved upper limits are in agreement with the extrapolation of the HE -ray spectrum, corrected for EBL absorption, from Fermi-LAT. The second part of the MAGIC observations in 2011 was triggered by a high-activity state in the optical and -ray bands. During the optical outburst the optical electri c vector position angle (EVPA) showed a rotation of∼ 180 ◦ . Unlike previous cases, there was no simultaneous rotation of the 43 GHz radio polarisation angle. No VHE -rays were detected by MAGIC, and the derived upper limits suggest the presence of a spectral break or curvature between the Fermi-LAT and MAGIC bands. The combined upper limits are the strongest derived to date for the source at VHE and below the level of the previously detected flux by a factor of ∼ 2. Radiation models that include synchrotron and inverse Compton emissions match the optical to -ray data, assuming an emission component inside the broad line region with size R = 1.1× 10 16 cm and magnetic field B = 1.45 G responsible for the high-energy emission, and another one outside the broad line region and the infrared torus (R = 1.5× 10 17 cm and B = 0.8 G) causing the optical and low-energy emission. We also study the optical polarisation in
Energy Efficient Event Driven Video Streaming Surveillance Using SleepyCAM

Wireless Multimedia Sensor Networks (WMSN) are one of the emerging paradigms of the Internet of Things (IoT) that are used to retrieve content including scalar data, video and audio streams and still images from the physical environment. In contrast to scalar sensor (such as temperature and humidity sensor) nodes, multimedia sensor nodes capture high volumes of data and perform far more complex tasks that can be highly power consuming. In this paper, we present the design of energy efficient high resolution camera sensor node, that is capable of capturing a full HD video at 30fps, using off-the-shelf hardware for an event driven video streaming surveillance application. In order to achieve long battery life, we use an energy efficient motion detection and power management mechanism, called sleepyCAM, which uses a lowpower scalar sensor node to detect motion and wake-up a high resolution camera node when needed. We used Libellium Waspmote platform and raspberry pi (RPi) to implement the functionality of the low-power sensor node and the HD camera node, respectively. We validate our work using a baseline setup on a standby RPi that uses scalar sensor for motion detection. The results demonstrate that with the used hardware platform, the power consumption can be reduced by more than 99%.
The Design and Construction of K11: A Novel α-Helical Antimicrobial Peptide

Amphipathic α-helical antimicrobial peptides comprise a class of broad-spectrum agents that are used against pathogens. We designed a series of antimicrobial peptides, CP-P (KWKSFIKKLTSKFLHLAKKF) and its derivatives, and determined their minimum inhibitory concentrations (MICs) against Pseudomonas aeruginosa, their minimum hemolytic concentrations (MHCs) for human erythrocytes, and the Therapeutic Index (MHC/MIC ratio). We selected the derivative peptide K11, which had the highest therapeutic index (320) among the tested peptides, to determine the MICs against Gram-positive and Gram-negative bacteria and 22 clinical isolates including Acinetobacter baumannii, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus epidermidis, and Klebsiella pneumonia. K11 exhibited low MICs (less than 10 μg/mL) and broad-spectrum antimicrobial activity, especially against clinically isolated drug-resistant pathogens. Therefore, these results indicate that K11 is a promising candidate antimicrobial peptide for further studies.
Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation

Perturbation of lipid metabolism, especially of cholesterol homeostasis, can be catastrophic to mammalian brain, as it has the highest level of cholesterol in the body. This notion is best illustrated by the severe progressive neurodegeneration in Niemann-Pick Type C (NPC) disease, one of the lysosomal storage diseases, caused by mutations in the NPC1 or NPC2 gene. In this study, we found that growth cone collapse induced by genetic or pharmacological disruption of cholesterol egress from late endosomes/lysosomes was directly related to a decrease in axonal and growth cone levels of the phosphorylated form of the tumor suppressor factor p53. Cholesterol perturbation-induced growth cone collapse and decrease in phosphorylated p53 were reduced by inhibition of p38 mitogen-activated protein kinase (MAPK) and murine double minute (Mdm2) E3 ligase. Growth cone collapse induced by genetic (npc1−/−) or pharmacological modification of cholesterol metabolism was Rho kinase (ROCK)-dependent and associated with increased RhoA protein synthesis; both processes were significantly reduced by P38 MAPK or Mdm2 inhibition. Finally, in vivo ROCK inhibition significantly increased phosphorylated p53 levels and neurofilaments in axons, and axonal bundle size in npc1−/− mice. These results indicate that NPC-related and cholesterol perturbation-induced axonal pathology is associated with an abnormal signaling pathway consisting in p38 MAPK activation leading to Mdm2-mediated p53 degradation, followed by ROCK activation. These results also suggest new targets for pharmacological treatment of NPC disease and other diseases associated with disruption of cholesterol metabolism.
Affinity rank: a new scheme for efficient web search

Maximizing only the relevance between queries and documents will not satisfy users if they want the top search results to present a wide coverage of topics by a few representative documents. In this paper, we propose two new metrics to evaluate the performance of information retrieval: diversity, which measures the topic coverage of a group of documents, and information richness, which measures the amount of information contained in a document. Then we present a novel ranking scheme, Affinity Rank, which utilizes these two metrics to improve search results. We demonstrate how Affinity Rank works by a toy data set, and verify our method by experiments on real-world data sets.
A Theory of Grammatical But Unacceptable

1 2 Acknowledgments This work is based largely on my Carnegie Mellon University dissertation, under the direction of Jill Lehman and Allen Newell. In addition, the following people provided valuable assistance and input: Amparo Chacon and the staa of Compassion International in Bogott a, Abstract What precisely is the universal nature of the human syntactic parser, such that it copes easily with some embedded structures, yet fails so dramatically on others (e.g., classic double center-embeddings)? A theory is proposed in the form of an architecture for parsing based on two simple ideas. The rst is that human short-term memory is an indexing structure which can give rise to interference eeects (storage limitations) when contents overlap with respect to the indices. For parsing, the contents are syntactic structures, and the indices are potential structural relations. The second idea is that the capacity of STM is the minimum capacity required to support the basic functions of parsing. The theory successfully accounts for the contrasts between over 50 diicult and acceptable constructions from English, French, German, Hebrew, Japanese, Mandarin, and Spanish. The theory has independent psychological and computational motivation, and is a functional part of a broader cognitive theory of comprehension, NL-Soar, which has been implemented as a working computer program.
Two RING Finger Proteins, the Oncoprotein PML and the Arenavirus Z Protein, Colocalize with the Nuclear Fraction of the Ribosomal P Proteins

ABSTRACT The promyelocytic leukemia (PML) protein forms nuclear bodies which are relocated to the cytoplasm by the RNA virus lymphocytic choriomeningitis virus (LCMV). The viral Z protein directly binds to PML and can relocate the nuclear bodies. Others have observed that LCMV virions may contain ribosomes; hence, we investigated the effects of infection on the distribution of ribosomal P proteins (P0, P1, and P2) with PML as a reference point. We demonstrate an association of PML bodies with P proteins by indirect immunofluorescence and coimmunoprecipitation experiments, providing the first evidence of nucleic acid-binding proteins associated with PML bodies. We show that unlike PML, the P proteins are not redistributed upon infection. Immunofluorescence and coimmunoprecipitation studies indicate that the viral Z protein binds the nuclear, but not the cytoplasmic, fraction of P0. The nuclear fraction of P0 has been associated with translationally coupled DNA excision repair and with nonspecific endonuclease activity; thus, P0 may be involved in nucleic acid processing activities necessary for LCMV replication. During the infection process, PML, P1, and P2 are downregulated but P0 remains unchanged. Further, P0 is present in virions while PML is not, indicating some selectivity in the assembly of LCMV.
Closed-loop optical neural stimulation based on a 32-channel low-noise recording system with online spike sorting

Objective. Closed-loop operation of neuro-electronic systems is desirable for both scientific and clinical (neuroprosthesis) applications. Integrating optical stimulation with recording capability further enhances the selectivity of neural stimulation. We have developed a system enabling the local delivery of optical stimuli and the simultaneous electrical measuring of the neural activities in a closed-loop approach. Approach. The signal analysis is performed online through the implementation of a template matching algorithm. The system performance is demonstrated with the recorded data and in awake rats. Main results. Specifically, the neural activities are simultaneously recorded, detected, classified online (through spike sorting) from 32 channels, and used to trigger a light emitting diode light source using generated TTL signals. Significance. A total processing time of 8 ms is achieved, suitable for optogenetic studies of brain mechanisms online.
Single nucleotide polymorphisms in new candidate genes are associated with bone mineral density and fracture risk.

OBJECTIVE Osteoporosis (OP) is a multifactorial disease with high heritability but its exact genetic background is still poorly understood. We examined the effect of 24 single nucleotide polymorphisms (SNPs) located in five genes--alkaline phosphatase, matrix metalloproteinase-2, tissue inhibitor of metalloproteases-2 (TIMP2), fibroblast growth factor receptor-1 (FGFR1), and fatty acid-binding protein-3 (FABP3)--previously not associated with OP. DESIGN We performed a genotype-phenotype association study at a university hospital. METHODS A total of 360 Hungarian postmenopausal women were involved in the study. Bone mineral density (BMD) was determined at spine, hip, and distal radius. Genomic DNA was extracted from venous blood samples and a high-throughput genotyping method based on single-based primer extension was applied for allelic discrimination. Robust statistical tools were utilized for multiplex data analysis. RESULTS SNP rs6996321 in FGFR1 was significantly related to spine BMD (P=0.002) and rs10914367 in FABP3 was associated with hip BMD (P=0.028). Non-vertebral fracture risk was significantly increased in carriers of 'A' allele of rs9900972 in TIMP2 (odds ratio=2.06, P=0.0187). We could also identify validated gene-gene interactions significantly affecting BMD and fracture risk. CONCLUSIONS We identified two previously unreported SNPs in FGFR1 and FABP3 associated with BMD and a third SNP in TIMP2 related to risk for non-vertebral osteoporotic fractures. This is the first report about the association between these allelic variants and the phenotypes of postmenopausal OP. Further studies need to clarify the role of these genes and their polymorphisms in the process of bone loss.
Analysis of Clinicopathologic Features and Prognostic Factors in Hepatoid Adenocarcinoma of the Stomach

ObjectiveTo investigate the different nature between hepatoid adenocarcinoma of the stomach (HAS) and common stomach cancer without the hepatoid differentiation areas (non-HAS). MethodsFrom January 1996 to December 2007, 45 patients were diagnosed as HAS on the basis of the characteristic histologic features resembling hepatocellular carcinoma in Fudan University Shanghai Cancer Center. The clinicopathologic features and the relevant prognosis of these patients were evaluated. In addition, 225 stage-matched common stomach cancer patients were selected as controls. ResultsHistologically, the polygonal tumor cells were arranged in trabecular fashion or solid nests separated by narrow fibrous stroma composed of sinusoid-like capillaries. Immunohistochemically, the tumor cells were positive for α-fetoprotein. Under transmission electron microscope, numerous circular granules of dense electron were found in the cytoplasm. HAS showed a higher rate of vascular invasion, lymph node metastasis, and liver metastasis than non-HAS. The 5-years survival rates of HAS and non-HAS were 9% and 44%, respectively. The prognosis of HAS was poorer than that of non-HAS (P<0.05). ConclusionHAS had different clinicopathologic features and prognosis from non-HAS.
Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat

This study was conducted to examine the role of myocardial ATP‐sensitive potassium (KATP) channels in exercise‐induced protection from ischaemia–reperfusion (I–R) injury. Female rats were either sedentary (Sed) or exercised for 12 weeks (Tr). Hearts were excised and underwent a 1–2 h regional I–R protocol. Prior to ischaemia, hearts were subjected to pharmacological blockade of the sarcolemmal KATP channel with HMR 1098 (SedHMR and TrHMR), mitochondrial blockade with 5‐hydroxydecanoic acid (5HD; Sed5HD and Tr5HD), or perfused with buffer containing no drug (Sed and Tr). Infarct size was significantly smaller in hearts from Tr animals (35.4 ± 2.3 versus 44.7 ± 3.0% of the zone at risk for Tr and Sed, respectively). Mitochondrial KATP blockade did not abolish the training‐induced infarct size reduction (30.0 ± 3.4 versus 38.0 ± 2.6 in Tr5HD and Sed5HD, respectively); however, sarcolemmal KATP blockade completely eradicated the training‐induced cardioprotection. Infarct size was 71.2 ± 3.3 and 64.0 ± 2.4% of the zone at risk for TrHMR and Sed HMR. The role of sarcolemmal KATP channels in Tr‐induced protection was also supported by significant increases in both subunits of the sarcolemmal KATP channel following training. LV developed pressure was better preserved in hearts from Tr animals, and was not influenced by addition of HMR 1098. 5HD decreased pressure development regardless of training status, from 15 min of ischaemia through the duration of the protocol. This mechanical dysfunction was likely to be due to a 5HD‐induced increase in myocardial Ca2+ content following I–R. The major findings of the present study are: (1) unlike all other known forms of delayed cardioprotection, infarct sparing following chronic exercise was not abolished by 5HD; (2) pharmacological blockade of the sarcolemmal KATP channel nullified the cardioprotective benefits of exercise training; and (3) increased expression of sarcolemmal KATP channels was observed following chronic training.
Optimal Redistricting Under Geographical Constraints: Why 'Pack and Crack' Does Not Work

We show that optimal partisan redistricting with geographical constraints is a computationally intractable (NP-complete) problem. In particular, even when voter's preferences are deterministic, a solution is generally not obtained by concentrating opponent's supporters in "unwinnable" districts ("packing") and spreading one's own supporters evenly among the other districts in order to produce many slight marginal wins ("cracking").
Modelling Smart Label-Supported Production Processes

Control of dynamics and complexity of logistic systems will continue to gain in importance in the future. One possibility to cope with this challenge is the concept of autonomous logistic processes that counts on using sophisticated smart labels. This article addresses the issue of requirements to a method for modelling autonomous logistic processes as well as the development of the method. It will give an overview to the created modelling and view concepts.
Determinants of health and disability in ageing population: the COURAGE in Europe Project (collaborative research on ageing in Europe).

UNLABELLED COURAGE in Europe was a 3-year project involving 12 partners from four European countries and the World Health Organization. It was inspired by the pressing need to integrate international studies on disability and ageing in light of an innovative perspective based on a validated data-collection protocol. COURAGE in Europe Project collected data on the determinants of health and disability in an ageing population, with specific tools for the evaluation of the role of the built environment and social networks on health, disability, quality of life and well-being. The main survey was conducted by partners in Finland, Poland and Spain where the survey has been administered to a sample of 10,800 persons, which was completed in March 2012. The newly developed and validated COURAGE Protocol for Ageing Studies has proven to be a valid tool for collecting comparable data in ageing population, and the COURAGE in Europe Project has created valid and reliable scientific evidence, demonstrating cross-country comparability, for disability and ageing research and policy development. It is therefore recommended that future studies exploring determinants of health and disability in ageing use the COURAGE-derived methodology. KEY PRACTITIONER MESSAGE COURAGE in Europe Project collected data on the determinants of health and disability in an ageing population, with specific tools for the evaluation of the role of built environment and social networks on health, disability quality of life and well-being. The COURAGE Protocol for Ageing Studies has proven to be a valid tool for collecting comparable data in the ageing population. The COURAGE in Europe Consortium recommends that future studies exploring determinants of health and disability in ageing use COURAGE-derived methodology.
On the Cauchy Problem and the Black Solitons of a Singularly Perturbed Gross-Pitaevskii Equation

We consider the one-dimensional Gross-Pitaevskii equation perturbed by a Dirac potential. Using a fine analysis of the properties of the linear propagator, we study the well-posedness of the Cauchy Problem in the energy space of functions with modulus 1 at infinity. Then we show the persistence of the stationary black soliton of the unperturbed problem as a solution. We also prove the existence of another branch of non-trivial stationary waves. Depending on the attractive or repulsive nature of the Dirac perturbation and of the type of stationary solutions, we prove orbital stability via a variational approach, or linear instability via a bifurcation argument.
CONTRIBUTION OF OATP (ORGANIC ANION-TRANSPORTING POLYPEPTIDE) FAMILY TRANSPORTERS TO THE HEPATIC UPTAKE OF FEXOFENADINE IN HUMANS

Fexofenadine hydrochloride (FEX), a second generation H1-receptor antagonist, is mainly eliminated from the liver into bile in unchanged form. Recent studies have shown that FEX can be accepted by human MDR1 (P-glycoprotein), OATP1A2 [organic anion-transporting polypeptide (OATP)-A, and OATP2B1 (OATP-B)] expression systems. However, other transporters responsible for the hepatic uptake of FEX have not yet been identified. In the present study, we evaluated the contribution of OATP family transporters, namely OATP1B1 (OATP2/OATP-C), OATP1B3 (OATP8), and OATP2B1 (OATP-B), to FEX uptake using transporter-expressing HEK293 (human embryonic kidney) cells. The uptake of FEX in OATP1B3-expressing cells was significantly greater than that in vector-transfected cells. On the other hand, OATP1B1- or OATP2B1-mediated uptake of FEX was not statistically significant. OATP1B3-mediated transport could be explained by a one-saturable component with a Michaelis constant (Km) of 108 ± 11 μM. The inhibitory effect of FEX on the uptake of estrone-3-sulfate (E1S), cholecystokinin octapeptide (CCK-8), and 17β-estradiol-17β-d-glucuronide (E217βG) was also examined. Both OATP1B1- and OATP1B3-mediated E217βG uptake was inhibited by FEX. The Ki values were 148 ± 61 and 205 ± 72 μM for OATP1B1 and OATP1B3, respectively. FEX also inhibited OATP1B3-mediated CCK-8 uptake and OATP1B1-mediated E1S uptake with a Ki value of 83.3 ± 15.3 and 257 ± 84 μM, respectively, suggesting that FEX could not be used as a specific inhibitor for OATP1B1 and OATP1B3, although FEX was preferentially accepted by OATP1B3. In conclusion, this is, to our knowledge, the first demonstration that OATP1B3 is thought to be a major transporter involved in hepatic uptake of FEX in humans.
Ontologies and the Knowledge Acquisition Bottleneck

Ontologies and information sharing have a major role to play in the development of knowledge-based agents and the overcome of the knowledge acquisition bottleneck. This paper supports this claim by presenting an approach to ontology specification, import, and development that is part of Disciple-RKF. Disciple-RKF is a theory, methodology, and learning agent shell for the rapid development of knowledge-based agents by subject matter experts, with limited assistance from knowledge engineers. The Disciple approach has been subject of intensive evaluations, as part of DARPA’s “High Performance Knowledge Bases” and “Rapid Knowledge Formation” programs, demonstrating very good results.
A Context-Aware Service Selection Mechanism Based on Hidden Markov Model

It is an important yet challenging problem that how to provide personalized services in pervasive environments. This paper explores the relationship between context and service requirements of customers, and proposes a service selection mechanism based on a modified Hidden Markov Model. Based on the contextual information, we build a novel Hidden Markov Model, and adjust its parameters dynamically by continuously changing context and invoked services. For a user, the service calling probabilities at current state can be calculated based on this model, which realizes personalized service selection. Meanwhile the user's next state can also be predicted, which realizes selecting in advance by roulette wheel algorithm. The prototype was tested in a campus environment, which verified the validity of the proposed method.