Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimizing Dual-Mode EEE Interfaces: Deep-Sleep is Healthy

The IEEE 802.3bj standard defines two potential low power operating modes for high speed energy efficient ethernet (EEE) physical interfaces working at 40 and 100 Gb/s: a not-so-efficient low power mode that requires very short transition times to restore normal operation (Fast-Wake) and a highly efficient low power mode with longer transition times (Deep-Sleep). In this paper, we present a new frame coalescing mechanism that dynamically adjusts the coalescing queue threshold in order to minimize the energy consumption of dual-mode EEE interfaces and maintains, at the same time, the average frame delay close to a target value. The proposed mechanism has been validated through simulation under different types of traffic (Poisson, self-similar, and real Internet traffic). In addition, we show that, with the current transition times and efficiency profiles of the standardized low power modes, our proposal renders the Fast-Wake mode unnecessary in most practical scenarios.
Abdominal adiposity assessed by dual energy X-ray absorptiometry provides a sex-independent predictor of insulin sensitivity in older adults.

BACKGROUND An increase in total adiposity and in particular an abdominal distribution of adiposity may contribute to the decline in metabolic insulin sensitivity observed in older men and women. The objective of this cross-sectional study was to determine which measure of abdominal adiposity would provide the best sex-independent predictor of metabolic insulin sensitivity in older men and women. METHODS Insulin sensitivity and abdominal adiposity were measured in healthy, nondiabetic older (64 +/- 6 years; mean +/- standard deviation) men (n = 23) and women (n = 31). Metabolic Insulin Sensitivity Index (S(I)) was determined from a frequently sampled insulin-assisted intravenous glucose tolerance test. Body fat mass and abdominal fat mass were determined from dual energy X-ray absorptiometry (DXA) scans. Anthropometric measures included waist and hip circumferences, height, and body weight. RESULTS Although waist circumference, waist index (waist circumference divided by height), and waist-hip ratio (WHR) were all lower in women than in men, there was no sex difference in DXA L1-L4 fat mass. In univariate analyses, S(I) was significantly inversely related with body weight, body mass index, waist circumference, waist index, percentage of total body and abdominal fat, and DXA L1-L4 fat mass but not with WHR. The DXA L1-L4 fat mass was identified as the best independent predictor of S(I), accounting for 41.2% of the variance (p <.0001) in a stepwise multiple regression model that controlled for sex. CONCLUSIONS WHR is not associated with S(I) in either men or women. Abdominal adiposity measured by DXA L1-L4 fat mass provides a sex-independent predictor of S(I) in older men and women.
Secreted proteases of Trypanosoma brucei gambiense: Possible targets for sleeping sickness control?

Human African trypanosomiasis (HAT) is caused by trypanosomes of the species Trypanosoma brucei and belongs to the neglected tropical diseases. Presently, WHO has listed 36 countries as being endemic for sleeping sickness. No vaccine is available, and disease treatment is difficult and has life‐threatening side effects. Therefore, there is a crucial need to search for new therapeutic targets against the parasite. Trypanosome excreted‐secreted proteins could be promising targets, as the total secretome was shown to inhibit, in vitro, host dendritic cell maturation and their ability to induce lymphocytic allogenic responses. The secretome was found surprisingly rich in various proteins and unexpectedly rich in diverse peptidases, covering more than ten peptidase families or subfamilies. Given their abundance, one may speculate that they would play a genuine role not only in classical “housekeeping” tasks but also in pathogenesis. The paper reviews the deleterious role of proteases from trypanosomes, owing to their capacity to degrade host circulating or structural proteins, as well as proteic hormones, causing severe damage and preventing host immune response. In addition, proteases account for a number of drug targets, such drugs being used to treat severe diseases such AIDS. This review underlines the importance of secreted proteins and especially of secreted proteases as potential targets in HAT‐fighting strategies. It points out the need to conduct further investigations on the specific role of each of these various proteases in order to identify those playing a central role in sleeping sickness and would be suitable for drug targeting. © 2013 BioFactors, 39(4):407–414, 2013
Reduced competence of immature and mature oocytes vitrified by Cryotop method: assessment by in vitro fertilization and parthenogenetic activation in a bovine model

Summary This study aimed to evaluate the embryo development competence, the nuclear maturation and the viability of germinal vesicle (GV) and metaphase II (MII) oocytes vitrified by the Cryotop method. Cumulus–oocyte complexes were derived from bovine ovaries and three experiments were conducted. In Experiment 1, GV oocytes were vitrified and underwent in vitro maturation (IVM) or not and their nuclear maturation was assessed by orcein staining. In Experiment 2, GV oocytes and MII oocytes were vitrified or not and the viability was assessed by calcein/ethidium homodimer-1 staining. In Experiment 3, MII oocytes matured before or after vitrification were submitted to in vitro fertilization (IVF) and parthenogenetic activation (PA) in order to evaluate embryo development. No difference was found for the nuclear maturation rate in the GV group (50%) and the GV control group (67%; P = 0.23) and for viability rate (56%; 77%; P = 0.055, respectively). However, in the MII group (27%) viability was significantly lower than that of the MII control group (84%; P < 0.0001). The cleavage rate by IVF and PA was similar in the GV group and the MII group. In contrast, vitrified MII oocytes showed no capacity for blastocyst development after IVF or PA and vitrified GV oocytes were able to develop to blastocysts only after PA, but not after IVF. In conclusion, oocyte vitrification by the Cryotop method reduced the capacity for embryo development. Vitrification of GV oocytes, however, did not influence the capacity of meiotic nuclear maturation and they exhibited higher viability following vitrification at the MII stage.
DeepIEP: a Peptide Sequence Model of Isoelectric Point (IEP/pI) using Recurrent Neural Networks (RNNs)

The isoelectric point (IEP or pI) is the pH where the net charge on the molecular ensemble of peptides and proteins is zero. This physical-chemical property is dependent on protonable/deprotonable sidechains and their pKa values. Here an pI prediction model is trained from a database of peptide sequences and pIs using a recurrent neural network (RNN) with long short-term memory (LSTM) cells. The trained model obtains an RMSE and R$^2$ of 0.28 and 0.95 for the external test set. The model is not based on pKa values, but prediction of constructed test sequences show similar rankings as already known pKa values. The prediction depends mostly on the existence of known acidic and basic amino acids with fine-adjusted based on the neighboring sequence and position of the charged amino acids in the peptide chain.
An operation scheme of UPFC's considering operating objectives and states

This paper presents an operation scheme of UPFCs considering objectives and states of power system operation. Two modes of UPFC operation, an economic mode and a secure mode are proposed according to operating objectives and states. In the economic mode, both the generation cost and the active power loss have been minimized by active and reactive power control of UPFC's. In the secure mode, the security index J relating to line flows and bus voltages has been minimized by operation of UPFC's. A decoupled model has been utilized as a mathematical model to evaluate the effect of an UPFC on a system. For verification of the proposed operation scheme, numerical simulations have been performed on a 10-unit, 39-bus New England System equipped with 3 UPFC's.
A DEA-based Efficiency-Measuring Model for a Two-Stage Production System

Data Envelopment Analysis(DEA)is a mathematical programming approach,which has been widely accepted as an effective tool to evaluate the efficiency of a Decision Making Unit(DMU) relative to other DMUs.Traditional DEA approaches usually treat the evaluated DMU as a 'BLACK BOX' and ignore its internal mechanism.This paper will advance a DEA-based method to evaluate the performance of a two-stage serial production system with consideration of its internal mechanism.Actually the advanced method in the paper is a special form of a Network DEA model,different from the pervious works but indeed helpful for managers to find out the reason and improvement of inefficiency for any two-stage serial production system,such as a supply chain.
Requirement of an Upstream AP-1 Motif for the Constitutive and Phorbol Ester-inducible Expression of the Urokinase-type Plasminogen Activator Receptor Gene*

The urokinase-type plasminogen activator receptor (u-PAR) facilitates extracellular matrix proteolysis by accelerating plasmin formation at the cell surface. The present study was undertaken to identify elements in the u-PAR promoter required for the elevated expression of this binding site. Toward this end, we used two cultured colon cancer cell lines; one (RKO) has a transcriptionally activated u-PAR gene, and the other (GEO) overexpresses the receptor only after phorbol ester treatment. A chloramphenicol acetyltransferase (CAT) reporter driven by 398 nucleotides of 5′ regulatory sequence of the u-PAR gene was strongly activated in the RKO cells, which displays approximately 3 × 105 receptors/cell. A region of this promoter between −197 and −8 was required for optimal expression, as indicated using a CAT reporter driven by 5′ deleted fragments. DNase I footprinting revealed three protected regions (I, −190 to −171; II, −148 to −124; and III, −99 to −70) in this part of the promoter. Mutation of an AP-1 binding site at −184 within region I reduced activation of the promoter by 85%. Deletion of either region II or III also reduced promoter activity by over 60%. An oligonucleotide spanning the AP-1 motif at −184 bound, specifically, nuclear factors from RKO cells, and antibodies specific for Jun-D, c-Jun, or Fra-1 proteins supershifted the complex indicating the presence of these proteins. The amount of these factors was reduced in GEO cells in which the u-PAR gene is only weakly transcriptionally activated. Expression of a vector encoding a wild-type Jun-D cDNA increased u-PAR promoter activity in GEO cells. Conversely, transfection of RKO cells with a transactivation domain-lacking Jun-D expression construct resulted in a dose-dependent decrease in u-PAR promoter activity. Treatment of GEO cells with phorbol ester increased u-PAR mRNA and the activity of a CAT reporter driven by the wild-type but not the AP-1 (−184)-mutated u-PAR promoter, and this was associated with a strong induction in the amount of Jun-D, c-Jun, and c-Fos. Methylation interference studies using a fragment of the u-PAR promoter (spanning −201 to −150) bound with nuclear extracted proteins from RKO cells, and phorbol 12-myristate 13-acetate-treated and -untreated GEO cells showed that the contact points corresponded to the AP-1 binding site at −184. Thus, the elevated expression of u-PAR in RKO cells, which constitutively produces this binding site, as well as in phorbol 12-myristate 13-acetate-stimulated GEO cells requires an AP-1 motif located 184 bp upstream of the transcriptional start site.
Firms’ Choice of Seasoned Equity Issuance Method—Taking Private or Non-private Route

The choice of an issuance method for selling subsequent equity is indeed an important corporate financial decision. The recent popularity of private placements over traditional seasoned equity offering (SEO) methods motivates this review on the determinants of firms’ choice between ‘private’ and ‘non-private’ routes for follow-on equity financing. Empirical results are generally consistent with the theoretical propositions. The review suggests further empirical evidence and importance of dynamic models to extensively explain the choice of an equity floatation method by listed companies.
Die Achillessehnenruptur - Erfahrungen aus 25 Jahren sportorthopädischer Behandlung

From 1972 - 1996 570 Achilles tendon ruptures in 565 patients were treated in the Sportklinik Stuttgart. The 499 men and 66 women had an average age of 38 years. For the diagnosis of a Achilles tendon rupture Ultrasound and MRI are important procedures, but clinical history and examination are still the best methods to find an Achilles tendon rupture (100%). However,the Actiology of the Achilles tendon rupture is still controversial and cannot be answered by these methods. Opposed to the degenerative theory, biomechanical experiments show that any Achilles tendon can tear when the calf muscle is tensed before the tendon is quickly stretched. We found that 69.8% of the patients with Achilles tendon rupture had a real trauma. Regardless of that, the treatment of the ruptured Achilles tendon has considerably changed over the last ten years. Responsible for this development are the positive experiences at the field of sports medicine with minimally invasive methods and the early functional treatment after knee surgery. Since we use an early functional rehabilitation concept instead of plaster immobilisation, all methods to treat a ruptured Achilles tendon have been improved. 43.5% of the patients after plaster immobilisation and 28.8% of the patients after early functional rehabilitation had a subjectively felt force reduction. Other important selecting criteria are the risk factors related to treatment method. Minimal invasive percutaneous Achilles tendon repair is considerably better than conservative therapy with a high rate of re-rupture (9.8%) and better than the open surgical repair, which carries a higher risk of infection (2.2%)
Use of Nonionic Surfactants for Improvement of Terpene Production in Saccharomyces cerevisiae

ABSTRACT To facilitate enzyme and pathway engineering, a selection was developed for improved sesquiterpene titers in Saccharomyces cerevisiae. α-Bisabolene, a candidate advanced biofuel, was found to protect yeast against the disruptive action of nonionic surfactants such as Tween 20 (T20). An experiment employing competition between two strains of yeast, one of which makes twice as much bisabolene as the other, demonstrated that growth in the presence of T20 provided sufficient selective pressure to enrich the high-titer strain to form 97% of the population. Following this, various methods were used to mutagenize the bisabolene synthase (BIS) coding sequence, coupled with selection by subculturing in the presence of T20. Mutagenesis targeting the BIS active site did not yield an improvement in bisabolene titers, although mutants were found which made a mixture of α-bisabolene and β-farnesene, another candidate biofuel. Based on evidence that the 3′ end of the BIS mRNA may be unstable in yeast, we randomly recoded the last 20 amino acids of the enzyme and, following selection in T20, found a variant which increased specific production of bisabolene by more than 30%. Since T20 could enrich a mixed population, efficiently removing strains that produced little or no bisabolene, we investigated whether it could also be applied to sustain high product titers in a monoculture for an extended period. Cultures grown in the presence of T20 for 14 days produced bisabolene at titers up to 4-fold higher than cultures grown with an overlay of dodecane, used to sequester the terpene product, and 20-fold higher than cultures grown without dodecane.
REVISTA DE CONTABILIDAD SPANISH ACCOUNTING REVIEW

The objective of this paper is to determine the effects of the corporate governance practices of central government agencies on the reliability of nancial reporting. There has been a considerable growth of these agencies across countries, and there are no studies about the relationship between the features of their corporate governance and the level of reliability of their financial reports. This paper provides evidence of systematic upward earnings management by agencies that apply the Private Sector Chart of Accounts to improve their financial performance and to compensate for the reduction of revenues during the worst years of the financial crisis. The results also show that abnormal accruals have a significant and inverse relationship with the percentage of independent directors and women on the boards, i.e., diversity improves the reliability of the financial information of these entities. ©2022 ASEPUC. Published by EDITUM Universidad de Murcia. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Códigos JEL: G34 H83 M41 Palabras clave: Gobierno corporativo Devengos discrecionales Agencias estatales España Gobierno Corporativo y Fiabilidad de la Información Financiera en las Agencias Gubernamentales Estatales
Differential Expression of IL-6/gp130 Cytokines, Jak-STAT Signaling and Neuroprotection After Müller Cell Ablation in a Transgenic Mouse Model.

PURPOSE It is anticipated that the interleukin-6/glycoprotein 130 (IL-6/gp130) family of cytokines and Jak-STAT signaling may be amenable to therapeutic manipulation for retinal diseases. Müller cells, which exhibit morphologic and functional changes in prevalent retinal diseases, are implicated in their induction and action. METHODS We characterized expression of endogenous IL-6/gp130 cytokines and Jak-STAT signaling after inducible Müller cell ablation in the neural retinas of adult mice. This resulted in photoreceptor apoptosis and reactive activation of surviving Müller cells. Analysis was performed by using a combination of quantitative real-time polymerase chain reaction, Western blot, and immunohistochemistry. Recombinant leukemia inhibitory factor (rLIF) was intravitreally injected in an attempt to inhibit photoreceptor degeneration following selective Müller cell ablation. RESULTS Significant differential expression (both increases and decreases) of multiple IL-6/gp130 cytokines, such as LIF, oncostatin-M, and ciliary neurotrophic factor, occurred after Müller cell ablation, with concomitant increase in signal transducers and activators of transcription and extracellular kinases 1 and 2, particularly in surviving, activated Müller cells. Basic fibroblast growth factor was robustly increased in photoreceptors after selective Müller cell ablation. Multiple injections of rLIF failed to prevent photoreceptor degeneration. CONCLUSIONS These results further characterize expression of IL-6/gp130 cytokines and Jak-STAT signaling in outer retinal disease, suggesting Müller cells are critical for their induction and action. Lack of rLIF-mediated neuroprotection contrasts with other retinal degenerations where Müller cell integrity remains intact or photoreceptor apoptosis occurs in a more rapid, synchronous manner. The presence of Müller cells may be critical for the functional benefits of rLIF and potentially other IL-6/gp130 cytokines.
Improved segmentation of ultrasound images for fetal biometry, using morphological operators

Currently, radiologists indicate the femur endpoints with an interactive marker device; however, these measurements are subjective and have proved to be inconsistent. The main objective of this work is to obtain a time-efficient morphology-based algorithm to recognize femur contour in fetal ultrasound images, refine its shape for automatic length measurement, and thus, attaining accuracy and reproducibility of measurement. To achieve these objectives a cross-sectional study with subjects belonging to different family units of different communities was carried out. The images obtained from the subjects were initially processed using morphological operators to remove the background from the image. Thereafter, to refine the shape of the femur, the images were metamorphosed, using the morphological operators, till a single pixel — wide skeleton of the femur was available in the most time-effective manner. The skeleton-end-points are assumed to be the femur-end-points, and the femur length is calculated as the distance between the end-points to estimate gestational age. The mean execution time of the proposed algorithm was around 4 seconds. Measurements, performed using the automation algorithm, were found to be closely correlated to those obtained manually. The proposed algorithm was found to be time-efficient, and the results obtained were comparable to those derived through the existing methods for estimation of gestational age.
Modelling Video Rate Evolution in Adaptive Bitrate Selection

Adaptive bitrate selection adjusts the quality of HTTP streaming video to a changing context. A number of different schemes have been proposed that use buffer state in the selection of the appropriate video rate. However, models describing the relationship between video quality levels and buffer occupancy are mostly based on heuristics, which often results in unstable and/or suboptimal quality. In this paper, we present a QoE-aware video rate evolution model based on buffer state changes. The scheme is evaluated within a real world Internet environment, where it is shown to improve the stability of the video rate. Up to 27% gain in average video rate can be achieved compared to the baseline ABR. The average throughput utilisation at a steady-state reaches 100% in some of the investigated scenarios.
Anthocyanin extraction from plant tissues: A review

ABSTRACT Anthocyanins have gathered the attention of the scientific community mostly due to their vast range of possible applications. They have been the center point of the research in many different fields, among which is food development, where their innate coloring, antioxidant capacity, and biological potential open interesting venues to the development of new food additives and functional foodstuffs. As the range of application grows, so does the necessity to obtain these compounds, and since they are naturally occurring, the most common way to obtain anthocyanins is to extract them from different plant sources, such as fruits and flowers. Several efforts have been made to develop methods that allow for better extraction yields and higher purification rates therefore this review aims to compile the information regarding extraction and purification procedures in a comprehensive manner.