Miracle-dz/UniFAR-FTUs huggingface dataset:
Block Disabling Characterization and Improvements in CMPs Operating at Ultra-low Voltages

Power density has become the limiting factor in technology scaling as power budget restricts the amount of hardware that can be active at the same time. Reducing supply voltage to ultra-low voltage ranges close to the threshold region has the promise of great energy savings. However, the potential savings of voltage scaling are limited by the correct operation of SRAM cells, which is not guaranteed below V(ddmin), the minimum voltage in which cache structures operate reliably. Understanding the effects of operating below V(ddmin) requires complex modelling, so we introduce an updated probability failure model of SRAM cells at 22nm and explore the reliability impact of lowering the chip voltage supply below V(ddmin) in shared memory coherent chip-multiprocessors (CMP) running a variety of parallel workloads. A micro architectural technique to cope with cache reliability at ultra-low voltages is block disabling, however, in many cases, the savings in on-chip caches do not compensate for the consumption in the rest of the system, as the consumption increase of the off-chip memory may offset the on-chip gain. We make the case that existing coherence mechanisms can provide the substrate to improve energy savings with block disabling and propose two low-complexity techniques. Taking the best of both techniques we can scale voltage below V(ddmin) and reduce system energy up to 39%, and system energy-delay up to 10%. Besides, by lowering the CMP consumption in a power constrained scenario, we could activate offline cores, reaching a potential speedup between 3.7 and 4.4.
Trichostatin A cooperates with Fas-mediated signal to induce apoptosis in rheumatoid arthritis synovial fibroblasts.

OBJECTIVE To clarify the effects of trichostatin A (TSA), a histone deacetylase inhibitor, on the growth and survival of rheumatoid arthritis synovial fibroblasts (RA-SF). METHODS Cell viability was assessed using a WST-8 assay and direct cell counting. Apoptosis was detected by annexin V staining on a flow cytometer. Protein and mRNA expression was determined by Western blotting, flow cytometry, and RT-PCR. RESULTS TSA suppressed cell growth of RA-SF in a dose-dependent manner, as determined by WST-8 assay and direct cell counting. Other histone deacetylase inhibitors also showed inhibitory effects on RA-SF proliferation. TSA upregulated p21(WAF1/CIP1) cell cycle inhibitor, suggesting that cell cycle arrest is involved in the reduction of cell numbers. In addition, TSA cooperated with Fas-induced pathway to induce cell death, determined by WST-8 assay and annexin V staining. TSA reduced FLICE inhibitory protein (FLIP) expression but not Bcl-2, Bcl-XL, and Fas expression, indicating that the synergistic effect may be through downregulation of FLIP. CONCLUSION TSA has antirheumatic effects on RA-SF and might be a potential therapeutic tool for the treatment of RA.
Emotion regulation strategies in individuals with cocaine use disorder maintained on methadone.

BACKGROUND AND OBJECTIVES Cognitive reappraisal (CR) and emotional suppression (ES), two emotion regulation strategies, are disrupted in other substance use disorders but have not been studied in cocaine dependence. METHODS Methadone-maintained individuals with cocaine dependence (N = 72) completed assessment of CR, ES, cocaine use, and psychiatric symptoms. RESULTS CR scores were associated with lower depression scores (r = -.29, p = .01), but not with cocaine abstinence during 8 weeks of treatment (r = .12, p = .29). CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE CR appeared relevant to cocaine-dependent individuals' depression, but was not associated with abstinence or treatment outcome. (Am J Addict 2016;25:529-532).
A psychophysical study of the effects of load and frequency upon selection of workload in repetitive lifting.

Human capabilities in manual materials-handling activities may be influenced by a number of task variables. The psychophysical method of Snook (1978) was used to determine the effects of load and lifting frequency upon workloads selected by eight male soldiers. The subjects repeatedly lifted and lowered a box (38 × 55 × 24 cm) to and from a platform set at 40% stature for 10 minutes and either adjusted the load, or the lifting frequency, or a combination of both variables in order to select a workload which they considered to be a maximum acceptable workload (MAWL) for a work-period of one hour. When the lifting frequency was adjusted, the mean MAWL was 94·5 kg m min −1 (S.D. 28·4). This was significantly greater (P ≤ 0·05) by 27% than when the load alone was adjusted (74·3 kg m min −1, S. D. 23·3). Control of both variables together produced a MAWL of 76·5 kg m min −1 (S. D. 24·1) which was similar to that selected when the load alone was adjusted. When the soldiers lifted and lowered their selected work.
Is there a tape recorder in your head? How the brain stores and retrieves musical melodies

Music consists of strings of sound that vary over time. Technical devices, such as tape recorders, store musical melodies by transcribing event times of temporal sequences into consecutive locations on the storage medium. Playback occurs by reading out the stored information in the same sequence. However, it is unclear how the brain stores and retrieves auditory sequences. Neurons in the anterior lateral belt of auditory cortex are sensitive to the combination of sound features in time, but the integration time of these neurons is not sufficient to store longer sequences that stretch over several seconds, minutes or more. Functional imaging studies in humans provide evidence that music is stored instead within the auditory dorsal stream, including premotor and prefrontal areas. In monkeys, these areas are the substrate for learning of motor sequences. It appears, therefore, that the auditory dorsal stream transforms musical into motor sequence information and vice versa, realizing what are known as forward and inverse models. The basal ganglia and the cerebellum are involved in setting up the sensorimotor associations, translating timing information into spatial codes and back again.
The notion of computation is fundamental to an autonomous neuroscience

The increasing sophistication of the tools and results of cellular and molecular neuroscience would appear to suggest that explanatory force in neuroscience is defined by reduction to molecular biology. This view, however, is mistaken in that it loses sight of the goal of neuroscience proper: the characterization of the information content of biophysical variables and the transformation of these variables that lead to behaviors. Neuroscience is thus distinguished from applied molecular and cellular biology by the notion of computation. In this commentary, I will show how the notion of computation in neuroscience differs from that of other fields that investigate complex systems and argue that computation at various levels of neural organization is the paramount goal of neuroscientific explanation and not the so-called reduction of “mind to molecules. ” © 2009 Wiley Periodicals, Inc. Complexity, 16,10–19, 2010
Sequencing and Scheduling in Coil Coating with Shuttles

Applying combinatorial optimization in real life yields cost savings delighting the industry. Beyond that, at the core of some applications also lies a pretty (sub)problem rejoicing the mathematician. In our application coils of sheet metal are coated with k layers out of hundreds of colors. Coils are stapled together to run through k coaters, and non-productive time occurs e.g. when the color in a coater needs to be changed. Some coaters have two parallel tanks, enabling either parallel colors or cleaning of one tank during production. We present our sequencing and scheduling scheme in use at the plant today, lower bounds proving solution quality, and problems in the edge-wise union of interval graphs as a pretty mathematical subproblem.
δ-strong classification rules for characterizing chemical carcinogens

This is a contribution to the Predictive Toxicology Challenge for 2000-2001. The goals of this challenge are to obtain models that predict carcinogenicity of chemicals using information related to chemical structure only. Our aim is to show the impact of δ-strong classification rule mining in such a domain. This new approach relies on recent results for association rule mining. It is based on δ-free set computation and provide the simplest classification rules. These rules characterize the classes and are used to build classifiers. This technique is operational for large data sets and can be used even in the difficult context of highly-correlated data where other algorithms fail.
Connexin29 Is Uniquely Distributed within Myelinating Glial Cells of the Central and Peripheral Nervous Systems

Although both Schwann cells and oligodendrocytes express connexin32 (Cx32), the loss of this connexin causes demyelination only in the PNS. To determine whether oligodendrocytes might express another connexin that can function in place of Cx32, we searched for novel CNS-specific connexins using reverse transcriptase-PCR and degenerate primers. We identified Cx29, whose transcript was restricted to brain, spinal cord, and sciatic nerve. Developmental expression of Cx29 mRNA in the CNS paralleled that of other myelin-related mRNAs, including Cx32. In the CNS, Cx29 antibodies labeled the internodal and juxtaparanodal regions of small myelin sheaths, whereas Cx32 staining was restricted to large myelinated fibers. In the PNS, Cx29 expression preceded that of Cx32 and declined to lower levels than Cx32 in adulthood. In adult sciatic nerve, Cx29 was primarily localized to the innermost aspects of the myelin sheath, the paranode, the juxtaparanode, and the inner mesaxon. Cx29 displayed a striking coincidence with Kv1.2 K+channels, which are localized in the axonal membrane. Both Cx29 and Cx32 were found in the incisures. Cx29 expressed in N2A cells did not induce intercellular conductances but did participate in the formation of active channels when coexpressed with Cx32. Together, these data show that Cx29 and Cx32 are expressed by myelinating glial cells with distinct distributions.
Endothelial adhesion molecules in glomerular lesions: association with their severity and diversity in lupus models.

BACKGROUND To clarify whether vascular endothelial adhesion molecules in glomeruli might contribute to the severity and diversity of glomerular lesions in lupus nephritis, their expression in lupus models was analyzed. METHODS The expression levels of E- and P-selectin and vascular cell adhesion molecule-1 (VCAM-1) in glomeruli of different histopathologic grades of MRL/MpJ-lpr/lpr (MRL/lpr) lupus mice was studied using laser-capture microdissection of the glomeruli, followed by reverse transcription-polymerase chain reaction (RT-PCR) analysis. The glomerular lesions in SCID mice injected with the 2B11.3 and 7B6.8 clones, which are derived from an MRL/lpr mouse and induce endocapillary proliferative and wire loop type of glomerular lesions, respectively, were analyzed. To investigate the effect of a soluble form of E-selectin (sE-selectin) on the development of glomerular lesions, sE-selectin-producing L cells were prepared by transfection of the cDNA encoding sE-selectin and injected into SCID mice. RESULTS The glomeruli in MRL/lpr mice showed increased expression of these adhesion molecules, corresponding to the severity of the glomerular lesions. The endocapillary proliferative type lesions in SCID mice induced by the 2B11.3 clone showed significantly increased expression of the adhesion molecules, especially E-selectin and P-selectin, but the wire loop type lesion induced by the 7B6.8 clone expressed only VCAM-1. Formation of the endocapillary proliferative type lesions induced by the 2B11.3 clone was markedly prevented in association with elevation of the serum level of sE-selectin produced by the tansfected L cells. CONCLUSION The severity and diversity of the histopathology of lupus nephritis are partially associated with the expression of vascular endothelial adhesion molecules in glomeruli.
Increased Cell Opening and Prolapse of Struts of a Neuroform Stent in Curved Vasculature: Value of Angiographic Computed Tomography: Technical Case Report

OBJECTIVE AND IMPORTANCE: To describe the use of a new imaging tool, angiographic computed tomography, for visualization of cell opening and strut prolapse of a Neuroform 2 stent (Boston Scientific/Target, Fremont, CA) placed in curved vasculature for treatment of a basilar tip aneurysm. CLINICAL PRESENTATION: A 46-year-old woman presented with an unruptured 8-mm basilar tip aneurysm with a wide patulous neck. INTERVENTION: A 4 × 20-mm Neuroform 2 stent was placed across the aneurysm neck. Angiographic computed tomographic scanning was performed using a flat detector biplane angiographic system with new commercially available software (Dyna-CT; Siemens Medical Solution, Forchheim, Germany) and the following parameters: 20-second acquisition, 0.4-degree increment, 512 matrix in projections, 220-degree total angle, 20 degree/s, and approximately 15 to 30 frames/s, for a total of 538 projections. Image postprocessing was performed to correct scattered radiation, beam hardening, and ring artifacts on a commercially available workstation (Leonardo, Siemens Medical Solutions, Erlangen, Germany). The aneurysm was coiled in a second session, using bare platinum coils without clinical sequelae. CONCLUSION: Increased opening of cells and prolapsing of struts of an open cell design stent can occur after placement in a curved vessel across an aneurysm orifice. Angiographic computed tomography is a new imaging tool that provides visualization of intracranial stents that is superior to digital subtraction angiogram or nonsubtracted images. It will enhance our understanding of stent behavior in clinical practice and improve the efficacy and safety of intracranial stent placement. Further in vitro and in vivo imaging studies of intracranial stents are necessary to assess the value of this promising new technique.
Fifth metacarpal neck fractures: fixation with antegrade locked flexible intramedullary nailing

Background: Fifth metacarpal neck fractures (commonly named “boxer’s fractures”) are the most common metacarpal injuries and usually affect young active people. These lesions are mainly treated conservatively. Their surgical management, if indicated, is still a matter of debate. Different procedures have been described. The aim of this study was to evaluate the outcomes of 18 boxer’s fractures which were synthesized with antegrade locked flexible intramedullary nailing. Materials and methods: All patients, at a mean follow-up of 45 months, were clinically evaluated using the Disabilities of the Arm, Shoulder and Hand (DASH) score and the Patient Rated Wrist/Hand Evaluation (PRWHE). Active and passive range of motion (ROM) of metacarpo-phalangeal (MP), proximal and distal interphalangeal (PIP and DIP) joints and Total Active Motion (TAM), and grip strength were also analyzed. Apex dorsal angulation and axial shortening were radiologically measured preoperatively and at final follow-up. Results: Clinical and radiological results which were observed were satisfactory. No TAM and grip strength differences were recorded between the operated and healthy contralateral hand. Conclusions: According to the positive outcomes and the low rate of complications of this study, antegrade locked flexible intramedullary nailing can be considered a valid treatment option in boxer’s fractures. (www.actabiomedica.it)
Testing of Four Leishmania Vaccine Candidates in a Mouse Model of Infection with Leishmania (Viannia) braziliensis, the Main Causative Agent of Cutaneous Leishmaniasis in the New World

ABSTRACT We evaluated whether four recombinant antigens previously used for vaccination against experimental infection with Leishmania (Leishmania) major could also induce protective immunity against a challenge with Leishmania (Viannia) braziliensis, the species responsible for 90% of the 28,712 annual cases of cutaneous and mucocutaneous leishmaniasis recorded in Brazil during the year of 2004. Initially, we isolated the homolog genes encoding four L. (V.) braziliensis antigens: (i) homologue of receptor for activated C kinase, (ii) thiol-specific antioxidant, (iii) Leishmania elongation and initiation factor, and (iv) L. (L.) major stress-inducible protein 1. At the deduced amino acid level, all four open reading frames had a high degree of identity with the previously described genes of L. (L.) major being expressed on promastigotes and amastigotes of L. (V.) braziliensis. These genes were inserted into the vector pcDNA3 or expressed as bacterial recombinant proteins. After immunization with recombinant plasmids or proteins, BALB/c mice generated specific antibody or cell-mediated immune responses (gamma interferon production). After an intradermal challenge with L. (V.) braziliensis infective promastigotes, no significant reduction on the lesions was detected. We conclude that the protective immunity afforded by these four vaccine candidates against experimental cutaneous leishmaniasis caused by L. (L.) major could not be reproduced against a challenge with L. (V.) braziliensis. Although negative, we consider our results important since they suggest that studies aimed at the development of an effective vaccine against L. (V.) braziliensis, the main causative agent of cutaneous leishmaniasis in the New World, should be redirected toward distinct antigens or different vaccination strategies.
Interactions of Streptococcus mutans Glucosyltransferase B with Lysozyme in Solution and on the Surface of Hydroxyapatite

Several active enzymes have been identified as components of acquired enamel pellicle. In the present study, the interactions of Streptococcus mutans glucosyltransferase B (GtfB) with lysozyme in solution and on the surface of hydroxyapatite (HA) beads were studied. Experiments were also performed to investigate whether structural differences exist between glucans formed by GtfB enzyme in the presence or absence of lysozyme in solution and on the surface of HA. Hen egg-white lysozyme (HEWL) and saliva were used as the sources of lysozyme; lysozyme-depleted saliva was used as control. Lysozyme activity was significantly reduced when adsorbed onto HA beads compared with that in solution. The GtfB enzyme did not affect the activity of lysozyme in solution or that of adsorbed lysozyme onto HA. The presence of HEWL increased GtfB activity; bovine serum albumin had an even greater enhancing effect. Depletion of lysozyme from whole saliva increased GtfB activity in solution, but not on the surface of saliva-coated HA. The presence of lysozyme affected the amount of glucan formation by GtfB, but not the structure of glucans formed in solution and on the surface. Therefore, the interaction of lysozyme and GtfB enzymes on HA surface may modulate the formation of glucan and dental plaque.
MG53 Regulates Membrane Budding and Exocytosis in Muscle Cells*

Membrane recycling and remodeling contribute to multiple cellular functions, including cell fusion events during myogenesis. We have identified a tripartite motif (TRIM72) family member protein named MG53 and defined its role in mediating the dynamic process of membrane fusion and exocytosis in striated muscle. MG53 is a muscle-specific protein that contains a TRIM motif at the amino terminus and a SPRY motif at the carboxyl terminus. Live cell imaging of green fluorescent protein-MG53 fusion construct in cultured myoblasts showed that although MG53 contains no transmembrane segment it is tightly associated with intracellular vesicles and sarcolemmal membrane. RNA interference-mediated knockdown of MG53 expression impeded myoblast differentiation, whereas overexpression of MG53 enhanced vesicle trafficking to and budding from sarcolemmal membrane. Co-expression studies indicated that MG53 activity is regulated by a functional interaction with caveolin-3. Our data reveal a new function for TRIM family proteins in regulating membrane trafficking and fusion in striated muscles.
The Influence of Top Management Team Heterogeneity on Firms' Competitive Moves

The authors acknowledge support from Columbia University's Management Institute. Warren Boeker, Sara Keck, John Michel, Peter Murmann, Michael Tushman, and Ruth Wageman made helpful suggestions on earlier drafts. We are grateful for access to the airline data base jointly assembled by the third author, Martin J. Gannon, Curtis M. Grimm, and Ken G. Smith. This paper explores the executive origins of firms' competitive moves by focusing on top management team characteristics, specifically on team heterogeneity, rather than on the more often studied environmental and organizational determinants of such behaviors. Arguing that competitive actions and responses represent different decision situations, we develop propositions about how heterogeneity may enhance some competitive behaviors but impair others. With a large sample of actions and responses of 32 U.S. airlines over eight years, we find results that largely conform to our propositions. The top management teams that were diverse, in terms of functional backgrounds, education, and company tenure, exhibited a relatively great propensity for action, and both their actions and responses were of substantial magnitude. Heterogeneous teams, by contrast, were slower in their actions and responses and less likely than homogeneous teams to respond to competitors' initiatives. Thus, although team heterogeneity is a double-edged sword, its overall net effect on airline performance, in terms of changes in market share and profits, was positive. *
Dietary effect of silage type and combination with camelina seed on milk fatty acid profile and antioxidant capacity of sheep milk

The present study sought to quantify the differences between maize-based (MS) and grass-silage-based (GS) diets in terms of their effect on the milk yield, milk fatty acid composition and antioxidant capacity in dairy ewes, and to test the hypothesis that it is possible to improve yield, fatty acid (FA) composition and antioxidant capacity by supplementing diet with camelina seed (Cs). Experimental diets consisted of a 2 x 2 factorial arrangement of type of silage (GS vs. MS) and camelina seed (−Cs vs. +Cs). Feeding the MS diets increased net energy for lactation (NEL) intake, raw milk yield and fat, protein and lactose yields. Feeding +Cs increased energy corrected milk (ECM), milk fat content and fat yield. Maize silage consumption is associated with an increased proportion of hypercholesterolemic fatty acids (HFA) and a higher value of the atherogenicity index. However, an MS diet led to an increased share of t11-C18:1 and c9,t11-conjugated linoleic acid (CLA) in milk. Milk FA profile in ewes fed GS diet was of higher quality for human beings owing to higher concentrations of α-linolenic acid and a lower content of HFA. Supplementing with camelina seed resulted in a higher concentration of t11-C18:1, c9,t11-CLA and C18:3n-3 in milk fat. The trolox equivalent antioxidant capacity (TEAC) value of milk was higher in milk from MS-fed ewes compared with that of their counterparts fed GS. Dietary supplementation with camelina seed increased the oxidative stability of milk samples. These results suggest that grass-silage-based diet supplemented with camelina seed results in milk of better quality for human consumption. Keywords : Milk quality, oilseed, PUFA profile, oxidative stability of milk, TEAC assay