Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Arrhythmogenic Mechanism Revealed by a Long-QT Syndrome Mutation in the Cardiac Na+ Channel

Variant 3 of the congenital long-QT syndrome (LQTS-3) is caused by mutations in the gene encoding the &agr; subunit of the cardiac Na+ channel. In the present study, we report a novel LQTS-3 mutation, E1295K (EK), and describe its functional consequences when expressed in HEK293 cells. The clinical phenotype of the proband indicated QT interval prolongation in the absence of T-wave morphological abnormalities and a steep QT/R-R relationship, consistent with an LQTS-3 lesion. However, biophysical analysis of mutant channels indicates that the EK mutation changes channel activity in a manner that is distinct from previously investigated LQTS-3 mutations. The EK mutation causes significant positive shifts in the half-maximal voltage (V1/2) of steady-state inactivation and activation (+5.2 and +3.4 mV, respectively). These gating changes shift the window of voltages over which Na+ channels do not completely inactivate without altering the magnitude of these currents. The change in voltage dependence of window currents suggests that this alteration in the voltage dependence of Na+ channel gating may cause marked changes in action potential duration because of the unique voltage-dependent rectifying properties of cardiac K+ channels that underlie the plateau and terminal repolarization phases of the action potential. Na+ channel window current is likely to have a greater effect on net membrane current at more positive potentials (EK channels) where total K+ channel conductance is low than at more negative potentials (wild-type channels), where total K+ channel conductance is high. These findings suggest a fundamentally distinct mechanism of arrhythmogenesis for congenital LQTS-3.
High Dynamic Range 3 D Display System with Projector and 3 D Color Printer Output

This demonstration describes a new high dynamic range (HDR) display system that generates a physical 3D HDR image without using stereoscopic methods. To boost contrast beyond that obtained using either a hardcopy or a projector, we employ a multiprojection system to superimpose images onto a textured solid hardcopy that is output by a 3D printer or a rapid prototyping machine. The physical contrast ratio obtained using our method was approximately 5,000:1, while it was 5:1 in the case of viewing the 3D printout under environmental light and 1,000:1 in the case of using the projectors to project the image on regular screens.
Improvement and Evaluation of the MS2SV for Mixed Systems Design Described in Abstraction High Level

This paper presents an important improvement of the MS2SV tool. The MS2SV performs the translation of mixed systems developed in MATLAB / Simulink for a structural or behavioral description in VHDL-AMS. Previously, the MS2SV translated only models of the LIB_MS2SV library. This improvement allows designer to create your own library to translation. As case study was used a rudder controller employed in an unmanned aerial vehicle. For comparison with the original model the VHDL-AMS code obtained by the translation was simulated in System Vision environment. The results proved the efficiency of the tool using the translation improvement proposed in this paper.
Planning with Observations and Knowledge

Robert P. Goldman and Mark S. Boddy and Louise Pryor{goldman,boddy} @src.honeywell. comlouisep@aisb.ed.ac.ukIntroductionWe are concerned with increasing the expressivenessof planning methods to handle observations and con-ditional execution. In previous work, two of us haveargued that one cannot correctly construct such a plan-ner without an explicit distinction between what is truein the world and what the agent knows (believes) be true (Goldman &: Boddy 1994b)1. Also in previouswork, one of us has created a planner, Cassandra, thatappears to construct flexible plans with conditional ex-ecution and knowledge-gathering without such a repre-sentation (Pryor & Collins 1995). The work describedhere was done to address the tension between these tworesults.To address these issues, we have developed a formal-ization of action, WCPL, based on propositional dy-namic logic (PDL). We have chosen dynamic logic as framework because it already has constructs we need,like conditionals and nondeterministic actions. PDL isalso closer to the kinds of action representation (e.g.,
Formalism for Relative Gromov-Witten Invariants

We develop a formalism for relative Gromov-Witten invariants of Li that is analogous to the Symplectic Field Theory of Eliashberg, Givental, and Hofer. This formalism allows us to express natural degeneration formulae in terms of generating functions and re-derive the formulae of Caporaso-Harris, Ran, and Vakil. In addition, our framework gives a homology theory analogous to SFT Homology.
Game service platform based on the real-time streaming

In order to implement the gaming service based on the real-time streaming, there are need many solution that game screen capture and audio/video encoding in real time created by high-performance server-generated game screen, and real-time streaming to the client device. So, we present a game service platform which is running and management of the game screen running on the server, captured and encoded screen provides a thin-client desktop by real-time streaming. It offer web-based services allowing game play on the smaller end-devices like low-cost PCs, set-top boxes and smart devices without requiring the games to be installed locally.
The robot engine — Making the unity 3D game engine work for HRI

HRI is a multi-disciplinary research field and integrating the range of expertise into a single project can be challenging. Enabling experts on human behavior to design fluent animations and behaviors for advanced robots is problematic, since the tools available for such robots are often in their prototype stage. We have built The Robot Engine (TRE) based on the Unity 3D Game Engine to control robots with Unity 3D. Unity 3D allows non-programmers to use a set of powerful animation and interaction design tools to visually program and animate robots. We review several animation techniques that are common in computer games and that could make the movements of robots more natural and convincing. We demonstrate the use of TRE with two different Arduino based robot platforms and believe that it can easily be extended for use with other robots. We further believe that this unconventional integration of technologies has the potential to fully bring the expertise of interaction designers into the process of advanced human-robot interaction projects.
Offshore Outsourcing: Risks, Challenges, and Potential Solutions

Abstract While offshore outsourcing is associated with several benefits, these ventures also pose many risks. In this paper, through an in-depth review, we develop a type 1 analysis theory about the various risks involved in offshore outsourcing projects, the challenges faced by managers in these collaboration initiatives, and solutions that may aid in overcoming those challenges. This paper contributes to both the theoretical and practice domains by providing a comprehensive offshoring challenges and solutions framework.
The Returns to Promotion of Healthy Choices in Tasmania: Are You in the Dark About the Power of Mushrooms?

The Australian Mushroom Growers Association (AMGA) has recently developed a revised marketing strategy to promote mushrooms using messages based on scientific findings about the nutrition and health consequences of regularly incorporating mushrooms into meals. This article evaluates impacts based on a test-market experiment in Tasmania. We use a difference-in-differences econometric methodology to quantify the programme-induced shifts in demand, and we use the resulting estimates in a supply and demand modelling framework to quantify the effects of promotion-induced demand shifts on prices, quantities, and measures of economic well-being. We estimate a conservative benefit–cost ratio for Tasmanian producers of 7.6:1 if they were to bear the entire cost and 11.4:1 if the programme were financed by a levy on production (or spawn). The aggregate benefit–cost ratio, including benefits to consumers is also 11.4:1. 1
Relevance Feedback using Query Logs

A search engine retrieves the documents based on the query su bmitted to it. However, incorporation of user modelling, by the inclusion of p ast information (like the previous queries submitted and the titles of the documents c licked) is expected to increase the accuracy of the search results. Especially, in the case of short term history, such history information is highly related with th e current user query and can help in explaining the user information needs in a batter way. In order to do the same, we develop and experiment with some “history incor poration and term reweighting” techniques that incorporate the user history along with the current query. These techniques expand the current query by includi ng terms from the history queries and the document titles, and reweight the te rms. The results confirm that the incorporation of history along with the current query is considerably better in performance than the usage of only the current quer y. We compare the retrieval models against each other and also analyze the combi nations of the retrieval models with the incorporation and reweighting techniques.
Meta-conformity approach to reliable classification

The conformity framework has recently been proposed for the task of reliable classification. Given a classifier B, the framework allows to obtain p-values of the classifications assigned to individual instances. However, applying the framework is a difficult problem: we need to construct an instance non-conformity function for the classifier B. To avoid constructing such a function we propose a meta-conformity approach. If a conformity-based classifier M is available, the approach is to train M as a meta classifier that predicts the correctness of each classification of the classifier B. In this way the classification p-values of the classifier B are represented by the classification p-values of the classifier M. The meta-conformity approach can be used for constructing classifiers with predefined generalization performance. Experiments show that the approach results in classifiers that can outperform existing conformity-based classifiers.
Den politiska läroboken : bilden av USA och Sovjetunionen i norska, svenska och finländska läroböcker under kalla kriget

During the Cold War, Norway was a member of NATO, Sweden was neutral but depended on Western support in the event of a crisis, while Finland's foreign policy priority was to win and retain the Soviet Union's confidence. The purpose of the thesis is to study whether the three small states' different foreign policy choices had consequences for the ways in which the Soviet Union and the USA were depicted in school textbooks for history, geography, and social sciences in the period 1930 to 2004. To this end, a theory derived from small states' strategies to maintain their independence was applied to textbook production.The study demonstrates that there was a link between small state foreign policy and textbooks' accounts of the USA and Soviet Union. Swedish and Norwegian textbooks portray international conflicts from a legalistic perspective, taking the part of small states exposed to superpower aggression such as Vietnam and Afghanistan. In Finnish textbooks, however, an interest in defending small state's rights yielded to the need to demonstrate their goodwill towards the Soviet Union, which was described in far less critical terms than in Swedish and Norwegian textbooks. In time, in the name of neutrality, depictions of the USA also became increasingly uncritical.All three Nordic states had government authorities charged with inspecting and approving school textbooks. Foreign policy's chief influence on textbooks was not effected by direct oversight, however; instead, it was established indirectly by means of the social climate, which determined what was considered politically correct in the three countries, and it was to this that the textbooks' authors adapted their work.Textbooks are often said to be conservative and slow to change, but the thesis shows that in parts they were politically sensitive, rapidly adapting to changes in what society held to be politically correct.
AN ECONOMIC INVESTIGATION OF CAR USE IN THE NATIONAL TRANSPORT MODEL FOR GREAT BRITAIN

The need to resolve an apparent paradox motivated the analysis, which is presented in this paper. The paradox grew out of early econometric results that were published in a working paper for the 1997 National Road Traffic Forecast (DETR 1998). Although NRTF has been subsequently revised and updated, it remains of some interest to first look at the earlier results, if only to provide a fuller context of the current investigation. The paradox arises from a widely held belief that the elasticity of traffic with respect to fuel price was greater than the elasticity of car use with respect to fuel cost. However, preliminary analysis pointed to precisely the opposite inequality; that the use/cost elasticity should, at least in theory, exceed the traffic/price elasticity. Resolving these conflicting views is one of the major motivations for these economic investigations that are presented in this paper.
The Effectiveness of Literacy Coaches as Perceived by School Administrators, Classroom Teachers, and Literacy Coaches.

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Metals fate and transport modelling in streams and watersheds: state of the science and USEPA workshop review

B. S. Caruso,1Ł,† T. J. Cox,2 R. L. Runkel,3† M. L. Velleux,4 K. E. Bencala,5† D. K. Nordstrom,6† P. Y. Julien,4 B. A. Butler,7 C. N. Alpers,8† A. Marion9 and K. S. Smith3† 1 U.S. Environmental Protection Agency, Denver, Colorado, USA 2 CDM, Denver, Colorado, USA 3 U.S. Geological Survey, Denver, Colorado, USA 4 Colorado State University, Fort Collins, Colorado, USA 5 U.S. Geological Survey, Menlo Park, California, USA 6 U.S. Geological Survey, Boulder, Colorado, USA 7 Colorado School of Mines, Golden, Colorado, USA 8 U.S. Geological Survey, Sacramento, California, USA 9 University of Padua, Padua, Italy
Sonic Shapes: Visualizing Vocal Expression

Sound has been an overlooked modality in visualization. Why? Because it is ephemeral. We experience it as it happens, often in community with others. Then, the sound is gone. Furthermore, sound in human communication is multidimensional and includes the semantic meaning of words, the meaning of expressive verbal gestures (paralingual and prosodic components), the nonvocal gestures, and relational gestures. Even though we are able to record sound and play it back, we typically focus more on the semantic meaning of words. In this paper, we describe a voice analytics toolkit and present visualizations that focus on the relational and expressive verbal gestures in speech. By making the overlooked channels of human communication visible and persistent, we make it possible to see beneath the surface of our words. This insight will potentially enable the development of new applications for speech therapy, the quantization and visualization of vocal trends common to speakers with medical conditions such as autism spectrum disorder (ASD), the characterization and visualization of communication patterns common in different kinds of relationships and cultures, and the development of new kinds of creative, multimodal works.
Plasma lipids predict myocardial infarction, but not stroke, in patients with established cerebrovascular disease.

AIMS To evaluate the role of plasma lipids in recurrent vascular events, including stroke, among individuals with established cerebrovascular disease. METHODS AND RESULTS Plasma total cholesterol, HDL cholesterol, and triglycerides were measured at baseline among individuals participating in the Perindopril Protection Against Recurrent Stroke (PROGRESS) study, a randomized clinical trial of blood pressure lowering among patients with previous stroke or transient ischaemic attack. A series of nested case-control studies were used to investigate the association between each of these lipid variables and the risk of subsequent haemorrhagic stroke, ischaemic stroke, myocardial infarction (MI), and heart failure. A total of 895 patients were selected as cases (83 haemorrhagic stroke, 472 ischaemic stroke, 206 MI, and 258 heart failure) and each was matched with one to three controls. After adjustment for other major cardiovascular risk factors, none of the lipid variables was associated with the risk of either stroke subtype. There were significant positive and negative associations for total cholesterol and HDL, respectively, with the risk of MI; the odds ratio comparing the highest and lowest thirds of each of these lipid variables was 2.00 (95% CI: 1.30-3.09) for total cholesterol and 0.58 (95% CI: 0.37-0.90) for HDL. HDL was inversely associated with the risk of heart failure; however, this result was of borderline statistical significance (P=0.05). CONCLUSION Lipid variables are associated with the risk of MI, but not recurrent stroke, in patients with established cerebrovascular disease.
Spatiotemporal Characteristics of Dry-Wet Abrupt Transition Based on Precipitation in Poyang Lake Basin, China

The dry-wet abrupt transition (DWAT) is a typical anomaly of precipitation at the subseasonal scale and may result in a severer and greater hydro-meteorological hazard. This paper identified and examined the DWAT events in terms of precipitation in Poyang Lake basin, including both from dry to wet (DTW) and from wet to dry (WTD), during the period of 1960–2010 and analyzed its characteristics of temporal and spatial distribution and intra- and inter-annual tendencies based on the Mann–Kendall (M–K) test. The results revealed that the DTW was inclined to occur in March, but WTD in July and September; the inter-annual variation of the DWAT index showed a feeble long-term increasing trend in July and a decreasing trend in September with a Z-statistic of 1.81 and −1.44, respectively, although none of these trends achieved the statistical significance level (α = 0.05); the north parts of Poyang Lake basin experienced more DWAT events during the last 50 years in which the occurrence of WTD is more frequent than that of DTW. The outcomes of the study will help mitigate and regulate the flood and drought in Poyang Lake basin, as well as in other regions.
Usutu Virus: An Emerging Flavivirus in Europe

Usutu virus (USUV) is an African mosquito-borne flavivirus belonging to the Japanese encephalitis virus serocomplex. USUV is closely related to Murray Valley encephalitis virus, Japanese encephalitis virus, and West Nile virus. USUV was discovered in South Africa in 1959. In Europe, the first true demonstration of circulation of USUV was reported in Austria in 2001 with a significant die-off of Eurasian blackbirds. In the subsequent years, USUV expanded to neighboring countries, including Italy, Germany, Spain, Hungary, Switzerland, Poland, England, Czech Republic, Greece, and Belgium, where it caused unusual mortality in birds. In 2009, the first two human cases of USUV infection in Europe have been reported in Italy, causing meningoencephalitis in immunocompromised patients. This review describes USUV in terms of its life cycle, USUV surveillance from Africa to Europe, human cases, its cellular tropism and pathogenesis, its genetic relationship with other flaviviruses, genetic diversity among USUV strains, its diagnosis, and a discussion of the potential future threat to Asian countries.
Spice Based Circuit Analysis Using Web Pages

An application called the Spice Internet Package (SIP) has been developed for use through the Internet and intranet networks. The SIP provides an interface that is operating independent, which allows Spice simulation and analysis to be performed from any computer that has a web browser on the Internet or intranet. One can access the Spice Internet Package and try some examples with the password “sip” at the following URL: http://atlantis.uwyo. edu/sip for UNIX server and http://nn.uwyo. edu/sip/ or http://sant.bradley. edu/sip/ for Windows NT server. The presentation shows how to use the new opportunity created by Internet technologies for the efficient and platform independent usage of CAD tools. The presented SIP is just an example, but it shows the way in which the technology can be implemented. They also illustrate how significant the impact is of a particular data flow on the programming tools and approaches taken to implement the Internet access to server-installed software. The authors are convinced that such an approach is suitable for pay-per-use access and it may revolutionize the general approach toward the development of CAD tools.
ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation

In amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration, TAR DNA binding protein 43 (TDP-43) accumulates in the cytoplasm of affected neurons and glia, where it associates with stress granules (SGs) and forms large inclusions. SGs form in response to cellular stress, including endoplasmic reticulum (ER) stress, which is induced in both familial and sporadic forms of ALS. Here we demonstrate that pharmacological induction of ER stress causes TDP-43 to accumulate in the cytoplasm, where TDP-43 also associates with SGs. Furthermore, treatment with salubrinal, an inhibitor of dephosphorylation of eukaryotic initiation factor 2-α, a key modulator of ER stress, potentiates ER stress-mediated SG formation. Inclusions of C-terminal fragment TDP-43, reminiscent of disease-pathology, form in close association with ER and Golgi compartments, further indicating the involvement of ER dysfunction in TDP-43-associated disease. Consistent with this notion, over-expression of ALS-linked mutant TDP-43, and to a lesser extent wildtype TDP-43, triggers several ER stress pathways in neuroblastoma cells. Similarly, we found an interaction between the ER chaperone protein disulphide isomerase and TDP-43 in transfected cell lysates and in the spinal cords of mutant A315T TDP-43 transgenic mice. This study provides evidence for ER stress as a pathogenic pathway in TDP-43-mediated disease.