Miracle-dz/UniFAR-FTUs huggingface dataset:
Absolute risk of suicide after first hospital contact in mental disorder.

CONTEXT Estimates of lifetime risk of suicide in mental disorders were based on selected samples with incomplete follow-up. OBJECTIVE To estimate, in a national cohort, the absolute risk of suicide within 36 years after the first psychiatric contact. DESIGN Prospective study of incident cases followed up for as long as 36 years. Median follow-up was 18 years. SETTING Individual data drawn from Danish longitudinal registers. PARTICIPANTS A total of 176,347 persons born from January 1, 1955, through December 31, 1991, were followed up from their first contact with secondary mental health services after 15 years of age until death, emigration, disappearance, or the end of 2006. For each participant, 5 matched control individuals were included. MAIN OUTCOME MEASURES Absolute risk of suicide in percentage of individuals up to 36 years after the first contact. RESULTS Among men, the absolute risk of suicide (95% confidence interval [CI]) was highest for bipolar disorder, (7.77%; 6.01%-10.05%), followed by unipolar affective disorder (6.67%; 5.72%-7.78%) and schizophrenia (6.55%; 5.85%-7.34%). Among women, the highest risk was found among women with schizophrenia (4.91%; 95% CI, 4.03%-5.98%), followed by bipolar disorder (4.78%; 3.48%-6.56%). In the nonpsychiatric population, the risk was 0.72% (95% CI, 0.61%-0.86%) for men and 0.26% (0.20%-0.35%) for women. Comorbid substance abuse and comorbid unipolar affective disorder significantly increased the risk. The co-occurrence of deliberate self-harm increased the risk approximately 2-fold. Men with bipolar disorder and deliberate self-harm had the highest risk (17.08%; 95% CI, 11.19%-26.07%). CONCLUSIONS This is the first analysis of the absolute risk of suicide in a total national cohort of individuals followed up from the first psychiatric contact, and it represents, to our knowledge, the hitherto largest sample with the longest and most complete follow-up. Our estimates are lower than those most often cited, but they are still substantial and indicate the continuous need for prevention of suicide among people with mental disorders.
Second-generation cryoballoon ablation for paroxysmal atrial fibrillation: 1-year follow-up.

BACKGROUND The novel cryoballoon Advance (CB-A) has proven to achieve significantly lower temperatures and faster pulmonary vein isolation (PVI) times in comparison with the first-generation device. Although acutely very effective, to the best of our knowledge, data on mid-term clinical follow-up is lacking. AIMS The aim of the study was to analyse the freedom from recurrence of atrial fibrillation (AF) on a 1-year follow-up period, in a series of consecutive patients having undergone PVI with the CB-A for paroxysmal AF (PAF). METHODS AND RESULTS Forty-two patients [30 male (71%); mean age: 57.9 ± 21.1 years] were included. All patients underwent a procedure with the large 28 mm CB-A. A total 168 PVs were depicted on the pre-procedural computed tomography scan. All PVs (100%) could be isolated with the CB only. The freedom from AF off-antiarrhythmic drug treatment after a single procedure was 78% of patients at a mean 11.6 ± 2.0 months follow-up. If considering a blanking period (BP) of 3 months, success rate was 83%. Phrenic nerve palsy (PNP) was the most frequent complication occurring in 19% of individuals. CONCLUSION The CB-A is very effective in producing PVI and affords freedom from AF at 12 months follow-up in 83% of patients affected by drug-resistant PAF following a 3-month BP. The most frequent complication observed was PNP which occurred in 19% of patients. All PNP reverted during follow-up.
An Interpretation for the ROC Curve and Inference Using GLM Procedures

Summary. The accuracy of a medical diagnostic test is often summarized in a receiver operating characteristic (ROC) curve. This paper puts forth an interpretation for each point on the ROC curve as being a conditional probability of a test result from a random diseased subject exceeding that from a random non diseased subject. This interpretation gives rise to new methods for making inference about ROC curves. It is shown that inference can be achieved with binary regression techniques applied to indicator variables constructed from pairs of test results, one component of the pair being from a diseased subject and the other from a non diseased subject. Within the generalized linear model (GLM) binary regression framework, ROC curves can be estimated, and we highlight a new semiparametric estimator. Covariate effects can also be evaluated with the GLM models. The methodology is applied to a pancreatic cancer dataset where we use the regression framework to compare two different serum biomarkers. Asymptotic distribution theory is developed to facilitate inference and to provide insight into factors influencing variability of estimated model parameters.
Phase 2 Study of Acupuncture-Like Transcutaneous Nerve Stimulation for Chemotherapy-Induced Peripheral Neuropathy

A prospective phase 2 study was conducted to evaluate the clinical utility of acupuncture-like transcutaneous nerve stimulation (ALTENS) for the treatment of chemotherapy-induced peripheral neuropathy (CIPN). Eligible cancer patients had a < 2 ECOG performance score, received neurotoxic chemotherapy, and developed CIPN symptoms for > two months. Randomization was used to eliminate bias in patient selection for ALTENS and was not to compare the effectiveness between the two treatments.ALTENS treatments were delivered using Codetron units. Bilateral acupuncture points included LI4 and LIV3, plus LI11 or ST36 were stimulated. Acupuncture treatments were administered to CV6, SP6, ST6, LI11, Bafeng, Baxie and selective Jing points bilaterally. Twelve treatments were delivered twice weekly over 6 to 8 weeks. The Modified Total Neuropathy Score (mTNS), Numbness Score, and Edmonton Symptom Assessment Score (ESAS) were assessed at baseline, treatment completion, plus at 3 and 6 months follow-up. The primary study endpoint was mTNS score at 6 months. We planned to recruit 23 patients into each group. After 30 patients were recruited, 2 were lost to follow-up at 3 months in the ALTENS group and 3 in the acupuncture group. The research team decided to recruit all remaining consecutive patients only to the ALTENS group to ensure an adequate evaluation of ALTENS, the primary object of evaluation. There were 27 patients in the ALTENS group, with an average symptom duration of 10 months after chemotherapy. Twenty four and 23 patients completed the 3 and 6 month follow-up respectively. The median mTNS scores were 7.1, 4.0, 3.6 and 3.1 at baseline, treatment completion, 3 and 6 months follow-up, respectively. One-way ANOVA analysis showed a significant improvement in mTNS scores (p<0.001) at 6 months. Numbness scores were also significantly improved at 6 months. ESAS pain scores and perception of well-being scores analyses were inconclusive. There were no significant reported side effects of ALTENS. There were only 13 patients in the acupuncture group and the number was insufficient for either an independent or a comparative analysis. The results of this study suggests that ALTENS significantly reduces the mTNS scores and numbness in patients suffering from CIPN symptoms.
Plasticity of fixation in patients with central vision loss

Abstract The aim of this study was to explore the plasticity of fixation in patients with central vision loss. Most of these patients use preferred retinal loci (PRLs) in the healthy eccentric part of the retina to fixate, but fixation stability and retinal location are not always optimal for best visual performance. This study examined whether fixation stability and a new PRL location can be trained and whether these changes in ocular motor control transfer into better reading performance. Six patients with age-related macular degeneration participated in the study. Fixation stability measurements, microperimetry, and auditory biofeedback training were performed with the MP-1 microperimeter. The auditory biofeedback was used during five 1-h long training sessions to improve fixation and relocate the PRL. Fixation location and stability were recorded while viewing four different targets: a cross, a letter, a word, and a nine-cycle radial grating. Visual acuity was assessed with the Early Treatment Diabetic Retinopathy Study (ETDRS) chart and reading performance with the MNRead test. The results showed that all patients developed a new PRL in an optimal location for reading, and they were able to use it consistently while viewing different targets. Fixation stability improved 53% after training. Learning transferred to the old PRL even though fixation stability at this location was not trained. All these improvements in ocular motor control translated into better reading performance: reading speed improved 38% and reading acuity and critical print size gained two lines. We conclude that the ability of the ocular motor system to fixate is flexible in patients with central vision loss: a new PRL can be trained, fixation stability can be improved, and learning transfers to an untrained location. These gains in ocular motor control result in better visual performance. This property can be successfully used to optimize the residual vision of patients with central vision loss.
An Ultrastructural and Immunocytochemical Analysis of Leptomeningeal and Meningioma Cultures

Using immunocytochemical methods, we localized several glycoproteins of the extracellular matrix to leptomeningeal cells and meningiomas in vitro. Three cell lines derived from normal human leptomeninges and seven from meningiomas were studied by indirect immunofluorescence to evaluate the cellular production of fibronectin, laminin, collagen type IV, and procollagen type III. All leptomeningeal cell lines stained intensely and uniformly for all matrix proteins; all meningioma cell cultures stained uniformly, but the intensity of staining varied considerably. After removal of the cells in culture adherent to glass with 25-mM ammonium hydroxide, indirect immunofluorescence demonstrated an exuberant residual extracellular residue enriched with fibronectin, laminin, collagen type IV, and procollagen type III. Electron microscopic examination of all leptomeningeal and meningioma cultures revealed desmosomes and dense tonofilament formation; in addition, granular, filamentous basement membrane-like material was abundant in the extracellular spaces of all cultures. Sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis of the cell layer of two leptomeningeal and four meningioma cultures showed production of interstitial collagen types I and III; diethylaminoethyl (DEAE)-cellulose chromatography of the medium demonstrated preferential production of procollagen type I. Our findings show conclusively that normal arachnoid cells in vitro synthesize several of the collagen subtypes and may be responsible for the “fibrous response” of the leptomeninges to trauma, infection, or infiltration by tumor. The similarities between leptomeningeal cells and meningiomas demonstrated by electron microscopy and by indirect immunofluorescence support the notion that meningiomas are derived from arachnoid cells. The localization of various mesenchymal glycoproteins within the intra- and extracellular spaces and the ubiquity of specialized intercellular junctions suggest that leptomeningeal cells in culture have the potential to behave like both stromal and epithelial cells.
Activation of Coagulation and Fibrinolysis Following OKT3 Administration to Renal Transplant Recipients: Association with Distinct Mediators

Summary Treatment with OKT3 induces cytokine release and activates the complement system. Since both phenomena may affect coagulation and fibrinolysis we studied these systems in 8 renal transplant recipients during OKT3 treatment. In 8 of 9 patients a similar pattern was observed: plasma thrombin-antithrombin-III-complex, tissue-type plasminogen-activator and plasmin-α2-antiplasmin-complex levels were increased as compared to pretreatment levels (p <0.05) at 15 min after the first OKT3 dose and reached peak values at 1 h. No significant changes were observed upon subsequent OKT3 administrations or in a control group of 8 patients. In one patient upon the first OKT3 administration only complement activation, and no cytokine release was observed, whereas plasma thrombin-antithrombin-III-complex, tissue-type plasminogen-activator and plasmin-α2-antiplasmin-complex levels increased only at 15 min. In conclusion, we demonstrate a biphasic activation of coagulation and fibrinolysis upon the first OKT3 dose; the initial phase seems to be associated with complement activation, the later phase with cytokine release.
A technique for calibrating derivative security pricing models: numerical solution of an inverse problem

A technique is presented for calibrating derivative security pricing models with respect to observed market prices. This technique can be applied in a very general multifactor setting where model parameters such as volatilities and correlations are allowed to be functions of the underlying state variables. These functions are estimated from price observations by solving the inverse problem associated with the parabolic partial differential equation governing arbitrage-free derivative security prices. A detailed exposition is given for consistent pricing of equity index options under a stochastic model that treats index volatility as a deterministic function of index level and time. Arbitrage-free pricing of derivative securities begins with the speci¢cation of a stochastic process that characterizes the underlying asset prices, indexes, or rates. Such processes typically incorporate one or more parameters (volatilities, correlations, etc.) that may be constants or deterministic functions. Assuming that the chosen process is a ‘realistic’ model for the underlying dynamics, the successful application in hedging and other trading activities will depend critically on how the parameters are quanti¢ed. The approach used to estimate parameters may vary depending upon the intended purpose for the pricing model. Frequently, the choice of parameters is based upon a forecast of the future behavior of the underlying, perhaps guided by statistical inference from past behavior. Another approach is to estimate the parameters by calibrating the pricing model with respect to observed market prices of actively traded derivative securities. This market calibration is typically employed when the purpose of the model is to price and hedge exotic derivatives within a framework that is consistent with the prices of more liquid exchange-traded instruments. In this paper, we present a technique for calibrating derivative pricing models with respect to observed market prices. This technique can be applied in a very general multifactor setting where model parameters such as volatilities and correlations are allowed tobe functions of the underlying state variables.We estimate these functions from a discrete and ¢nite set of price observations by solving the inverse problem associated with the parabolic partial diierential equation (PDE) governing arbitrage-free derivative security prices. A detailed exposition of the technique is given in the context of equity index options. Here we consider a single-factor stochastic model for the underlying index, incorporating a volatility that is both time and index-level dependent. This volatility function appears as a coe⁄cient of the second-order partial derivative in the pricing PDE and, in principle, can be uniquely determined given enough information about option price solutions. In practice, Calibrating derivative security pricing models 13
IMPACT OF INTRAOPERATIVE HIGH‐FIELD MAGNETIC RESONANCE IMAGING GUIDANCE ON GLIOMA SURGERY: A PROSPECTIVE VOLUMETRIC ANALYSIS

OBJECTIVETo determine the impact of intraoperative magnetic resonance imaging (iMRI) on the decision to proceed with additional glioma resection during surgery and to maximize extent of resection (EOR). METHODSPatients who underwent craniotomy for glioma resection with high-field iMRI guidance were prospectively evaluated between September 2006 and August 2007. Volumetric analysis and EOR were assessed with iMRI, using postcontrast T1-weighted images for tumors showing contrast enhancement and T2-weighted images for nonenhancing tumors. RESULTSForty-six patients underwent resection using iMRI guidance, with iMRI being used to evaluate the EOR in 44 patients and for reregistration in 2 patients. Surgery was terminated after iMRI in 23 patients (52%) because gross total resection was achieved or because of residual tumor infiltration in an eloquent brain region. Twenty-one patients (47%) underwent additional resection of residual tumor after iMRI. For enhancing gliomas, the median EOR increased significantly from 84% (range, 59%–97%) to 99% (range, 85%–100%) with additional tumor removal after iMRI (P < 0.001). For nonenhancing gliomas, the median EOR increased (from 63% to 80%) with additional tumor removal after iMRI, but not significantly, owing to the small sample size (7 patients). Overall, the EOR increased from 76% (range, 35%–97%) to 96% (range, 48%–100%) (P < 0.001). Gross total resection was achieved after additional tumor removal after iMRI in 15 of 21 patients (71%). Overall, 29 patients (65%) experienced gross total resection, and in 15 (52%), this was achieved with the contribution of iMRI. CONCLUSIONHigh-field iMRI is a safe and reliable technique, and its use optimizes the extent of glioma resection.
Inferences and Implications: Do results from the Diabetes Control and Complications Trial apply in NIDDM?

The long-standing debate of the glucose hypothesis appears to have been settled by the Diabetes Control and Complications Trial (DCCT). The DCCT conclusively demonstrated in insulin-dependent diabetes mellitus (IDDM) that intensive diabetes management, with the goal of lowering blood glucose concentrations to as close to the normal range as possible, decreases the risk of the development and progression of diabetic complications by 40-75% (1). In the wake of the DCCT, a furor has arisen regarding the use of intensive management in patients with other forms of diabetes, specifically non-insulin-dependent diabetes mellitus (NIDDM) (2-5). While the DCCT Research Group declined to advise implementation of intensive therapy in NIDDM, the American Diabetes Association equivocated but concluded that "it seems reasonable to recommend tight control in many patients with non-insulin-dependent disease. " (3). Concern regarding the implications of the DCCT for patients with NIDDM is well-founded because the vast majority of people with diabetes have NIDDM. To consider whether and how the DCCT results might be applied in NIDDM and, more specifically, whether similar glycemic goals as used in the DCCT should be pursued in NIDDM, the following issues must be addressed:
ILSES: Identification lysine succinylation-sites with ensemble classification

Lysine succinylation is one of most important types in protein post-translational modification, which is involved in many cellular processes and serious diseases. However, effective recognition of such sites with traditional experiment methods may seem to be treated as time-consuming and laborious. Those methods can hardly meet the need of efficient identification a great deal of succinylated sites at speed. In this work, several physicochemical properties of succinylated sites have been extracted, such as the physicochemical property of the amino acids. Flexible neural tree, which is employed as the classification model, was utilized to integrate above mentioned features for generating a novel lysine succinylation prediction framework named ILSES (identification lysine succinylation-sites with ensemble features classification). Such method owns the ability to combining diverse features to predict lysine succinylation with high accuracy and real time.
Reliability of Third Molar Development for Age Estimation by Radiographic Examination (Demirjian's Method).

INTRODUCTION Dental age estimation methods are of particular value because teeth are highly resistant to mechanical, chemical, or physical impacts and time. Teeth are the strongest parts in the human body and are therefore very resistant to external influences, such as extreme temperatures, explosions, and other extreme conditions, which make them available for extensive postmortem periods. AIM To correlate chronological age with dental age using Demirijian's method. MATERIALS AND METHODS The study was carried out on 100 digital orthopantamograms (OPG) of patients in the age group of 7 to 24 years. During the analysis, Magnify' and Ruler' tools were used. Mandibular right third molar was used for entire study. Data collected was analysed by using SPSS software. RESULTS Development of third molar in all stages was found slightly earlier in males than in females, when chronological age was compared with dental age using Demirjian method. 88% subject showed statistically significant linear correlation between chronological age and developmental age using Demirjian's method. CONCLUSION The linear correlation between chronological age and dental age using to Demirjian's method was more in age group above 16 years and less in age group below 16 years. Demirijian's method is a reliable guide for age estimation in age group of 7 to 24 years of age.
Water Transport in the Liana Bauhinia fassoglensis (Fabaceae).

To determine the efficiency of xylem conductance in the liana (woody vine) Bauhinia fassoglensis Kotschy ex Schweinf. , we measured hydraulic conductance per unit stem length (measured K(h)), leaf-specific conductivity (LSC = K(h)/distal leaf area), transpiration rate (E), xylem water potential (epsilon), vessel number, and vessel diameter. The measured K(h) was 49% (se = 7%) of the predicted K(h) from Poiseuille's law. The mean LSC for unbranched stem segments was 1.10 x 10(-8) square meters per megapascal per second (se = 0.07). LSCs were much lower (about 0.2) at branch junctions. At midday, with E at 7 x 10(-8) meters per second, the measured drop in epsilon was about 0.08 megapascal per meter along the stems and branches and about 0.27 megapascal in going from stem to leaf. In addition, there was a drop of about 0.20 megapascal at branch junctions as predicted by E/LSC. In diurnal measurements leaf epsilon never dropped below about -1.2 megapascal. For long (e.g. 16 meters) stems, the predicted mid-day drop in epsilon through the xylem transport system might be great enough to have substantial physiological impact.