Miracle-dz/UniFAR-FTUs huggingface dataset:
A Model of the Molecular Aggregate Processes of Hemoglobin S. Absence of Cristallization

Los mecanismos de formacion molecular agregada desempena un papel importante en la interpretacion de la patofisiologia de la anemia de celulas falciformes (o anemia drepanocitica), y en la seleccion de las estrategias terapeuticas a seguir. Aqui se propone un mecanismo y un modelo matematico. el modelo postula la existencia de microtubulos defectivos formados por deoxihemoglobina S y oxihemoglobina S, y explica la dependencia de la polimerizacion de la concentracion de hemoglobina, la temperatura y la presion parcial de oxigeno. El analisis hace enfasis en la polimerizacion de hemoglobina S en la ausencia de cristalizacion. La accion de otras clases de hemoglobinas en la formacion molecular agregada puede ser explicada.
WORKING WITH CLAY

Abstract Evidence from sites in the lower Ulua valley of north-central Honduras, occupied between a.d. 500 and 1000, provides new insight into the connections between households, craft production, and the role of objects in maintaining social relations within and across households. Production of pottery vessels, figurines, and other items in a household context has been documented at several sites in the valley, including Cerro Palenque, Travesía, Campo Dos, and Campo Pineda. Differences in raw materials, in what was made, and in the size and design of firing facilities allow us to explore how crafting with clay created communities of practice made up of people with varying levels of knowledge, experience, and skill. We argue that focusing on the specific features of a particular craft and the crafter's perspective gives us insight into the ways that crafting contributed to the reproduction of social identities, local histories, and connections among members of communities of practice who comprised multicrafting households.
Event-triggered output regulation for linear multi-agent systems

In this paper, we continue considering the distributed output regulation problem which mainly concerns the asymptotically tracking an active leader, and/or distributed disturbance rejection. Here we focus on the distributed output regulation with event driven strategies of multi-agent systems. The event driven control actuation updating depends on a trigger function with respect to a specified measurement error threshold. We consider both static and dynamic distributed feedback controllers with different trigger functions. Solvability conditions are proposed. Moreover, a systematic design approach is proposed to handle the event-triggered output regulation via dynamic state feedback with the help of internal model.
Impact study of the process thermal budget of advanced CMOS nodes on SiGe HBT performance

The objective of this paper is to predict the main electrical characteristics of SiGe NPN HBTs, like the transit frequency fT, internal capacitances and pinched base sheet resistance for the next CMOS nodes by means of process and hydrodynamic simulations. The as-deposited BiCMOS055 vertical doping profile is exposed to the thermal budgets from existing CMOS040, CMOS028, CMOS028FDSOI and CMOS014FDSOI technologies by TCAD simulation. Obtained results show that, thanks to the reduction of the process thermal budget, the maximum fT could reach 370 GHz with two different assumptions: identical doping level at both BE and BC junctions and identical BE capacitance. Additionally, the evolution of the dopants' diffusion with ST's fabrication steps is clarified for BiCMOS055 in this study.
Functional outcomes and quality of life in patients with brain tumours: a review of the literature

Objective: To review the literature with respect to functional outcomes and quality of life as it pertains to individuals with brain tumours. Main outcomes: Most functional outcome papers have focused on acute inpatient rehabilitation. In general, patients with brain tumours have comparable rates of functional gains as other models of neurologic disability. Tumour type and concomitant treatment do not impact functional outcome. Functional independence may predict survivability in certain populations. Numerous instruments are used to measure the multiple facets of quality of life. Depression, anger and fatigue can impact both physical and psychological aspects of quality of life. The physical and functional aspects can vary depending on the tumour type. Treatment regimens can negatively impact quality of life. Conclusion: Brain tumour patients experience changes in function and quality of life during their disease course. Rehabilitation services may offer a unique opportunity to influence both functional outcome and more closely assess quality of life in these individuals.
International Survey on the Management of Acute Kidney Injury in Critically Ill Patients: Year 2007

Introduction: Several aspects of acute kidney injury (AKI) management, including medical approaches to AKI patients and the optimal form of renal replacement therapy (RRT), remain a matter of debate. Subjects and Methods: The responses of 440 participants to a questionnaire on several points of AKI management, submitted during the 4th International Course on Critical Care Nephrology in June 2007, were analyzed. Results: The most common answer to the definition of AKI was the use of the RIFLE criteria (55%), followed by the presence of oligoanuria (24%). Responders seemed to preferentially start dialysis within a creatinine range from 2.3–3.4 mg/dl (28%) to 3.4–4.5 mg/dl (26%) and with a urine output level of 150–200 ml/12 h (43%). About 30% of responders showed that they would prescribe dialysis only in case of severe fluid overload (requiring mechanical ventilation and/or causing impaired skin integrity). Continuous RRT is used by most specialists (86%), followed by intermittent hemodialysis (65%), sustained low-efficiency dialysis (28%) and peritoneal dialysis (30%). The preferred RRT dosage was ‘35 ml/kg/h’ (46%) but 37% of responders did not explicitly answer this critical question. Bleeding, hypotension, filter clotting, vascular access and sepsis treatment were the most frequent complications and concerns of RRT. Conclusions: New classifications such as the RIFLE criteria did improve the well-known uncertainty about the definition of AKI. Awareness of the prescription and standardization of an adequate treatment dose seemed to have increased in recent years, even if there is still a significant level of uncertainty on this specific issue. Several concerns and RRT complications, such as bleeding and anticoagulation strategies, still need further exploration and development.
Influence of Phytophthora capsici L. inoculation on disease severity, necrosis length, peroxidase and catalase activity, and phenolic content of resistant and susceptible pepper (Capsicum annuum L.) plants

This study explored the level of infection caused by different inoculum concentrations (102, 103, and 104 zoospores mL-1) of Phytophthora capsici in 3 pepper cultivars at days 2, 4, and 6. The effect that the infection induced on the peroxidase (POX), catalase (CAT), and phenolics of resistant and sensitive seedlings, as well as the defense mechanism against the pathogen, were also investigated. The resistance of PM-702 against the isolate used was high, whereas KM-Hot and DEM-8 displayed sensitive reactions. As a result of analyses of the leaves and stems from the 3 pepper cultivars, important changes in biochemical parameters were observed between resistant and sensitive cultivars after inoculation with the root rot pathogen P. capsici. The maximum increase of POX and CAT was observed in the resistant PM-702 cultivar. However, with a high inoculum concentration (104 zoospores mL-1), a loss of CAT activity was determined, especially in susceptible cultivars. The maximum increase in phenolics was detected in leaves of susceptible DEM-8 and stems of PM-702 on day 6 following infection. The results suggest that during Phytophthora root rot development there is a relation between the disease induced by P. capsici and the antioxidant system.
Gel‐Immobilized Colloidal Crystal Shell with Enhanced Thermal Sensitivity at Photonic Wavelengths

Microcapsules are sub-millimeter sized core-shell structures that are often used for encapsulation applications. The shell not only protects the core materials but also imparts additional properties to the capsules. For example, shells have been made from various functional materials such as gels, [ 1 ] magnetic materials, [ 2 ] and liquid crystals [ 3 ] to impart desired mechanical strength, bio-compatibility, permeability, and release properties to the micro-capsules. Such microcapsules are often used for a variety of applications such as macromolecular delivery, [ 4 ] hazardous material handling, [ 5 ] oil recovery, [ 6 ] and food processing. [ 7 ] The choice of an appropriate shell material is important for the development of microcapsules with new functionalities for novel applications in pharmaceutical, food, cosmetic, and materials industries. Charge-stabilized colloidal crystals are three-dimensional periodic arrays of charged particles with low packing density in a liquid medium. [ 8 ] The spatial periodicity of the refractive index of the colloidal crystalline arrays results in an optical stop band effect, and, hence, they act as photonic crystals in the optical regime. [ 9 ] Since the charged colloids do not touch one another, the lattice constant can be conveniently tuned by changing the particle volume fraction. The wavelength of the optical stop band can be fi xed by immobilizing these crystals in a hydrogel. [ 10 ] The Bragg wavelength can be altered on-demand if a stimuli-sensitive hydrogel is used. By adjusting the volume of the hydrogel through an external stimulus, the lattice constant of the crystals can be tuned accordingly; this is useful for applications such as tunable photonic crystals, [ 11 ] tunable laser, [ 12 ] and biological and chemical sensors. [ 13 ] In particular, capsules with a shell of such colloidal crystals will enable labeling and monitoring of the encapsulated materials as well as the environment around the capsules through the wavelength of the optical stop band or diffraction color. In this Communication, we demonstrate that monodis-perse double emulsions with colloidal crystal shells can be fabricated through microfl uidic techniques. [ 14 ] The colloidal crystal shells are subsequently immobilized in the hydrogel network by photo-polymerization techniques. The wavelength of the optical stop band of the gel-immobilized colloidal crystal shell can be adjusted by simply varying the particle concentration before polymerization. Moreover, it can also be altered by external stimuli, such as temperature, after preparation …
Effect of angiotensin-converting enzyme inhibition on myocardial vascularization in the adolescent and adult spontaneously hypertensive rat

Objective To determine whether angiotensin-converting enzyme (ACE) inhibition treatment enhances myocardial vascularization in adolescent and adult spontaneously hypertensive rats (SHRs). Methods Male SHRs were treated from 7 to 14 or from 16 to 24 weeks of age with the ACE inhibitor, perindopril, in either a low dose (0.1 mg/kg per day) or a high dose (1 mg/kg per day). Some rats were concomitantly treated with a bradykinin antagonist. At termination of treatment, the left ventricular wall was extensively sampled and the surface area density and length density of myocardial blood vessels stereologically determined. Results High-dose perindopril treatment prevented the development of hypertension and left ventricular hypertrophy in adolescent SHRs and markedly reduced blood pressure and left ventricular size in adult SHRs. SHRs treated with the low dose of perindopril remained hypertensive, although there were significant reductions in blood pressure and left ventricular growth. High-dose perindopril treatment in adolescent SHRs led to a significant increase in the surface area density of blood vessels in the left ventricle after 4 weeks of treatment and an increase in both the surface area density and length density of blood vessels after 7 weeks of treatment. Co-administration with the bradykinin antagonist did not reverse these effects. In contrast, ACE inhibitor treatment had no effect on myocardial vascularization in adult rats with established hypertension. Conclusion ACE inhibitor treatment enhances vascularization in the adolescent heart through reductions in myocardial mass, but not capillary growth. ACE inhibition in the adult heart with established hypertension reduces left ventricular hypertrophy, but does not enhance myocardial capillarization.
Polyribosomes of Growing Bacteria

A method of extracting polyribosomes has been developed which uses lysozyme on bacteria in the exponential phase of growth. This procedure recovers more than 80 percent of the total ribonucleic acid and nearly all of the soluble protein. Analysis of the lysate on sucrose gradients shows that 80 to 90 percent of the ribosomes sediment with the polysome fractions, indicating little or no degradation. The method has been applied to both a Gram-positive and a Gram-negative organism under various growth conditions and has proved uniformly successful.
Automated Graduate Training Monitoring: The Case of Gulu University and Strategies for Institutional Adoption

Graduate completions per cohort in Africa is reportedly low and below 40%. This is attributed to several overlapping processes that must be monitored including; teaching, research supervision, and examination (internal and external) of research reports (dissertation/thesis). In this paper we present a generic graduate tracking system that manages the entire graduate training landscape. Essentially, the system handles: registration and assignment of user roles; assignment of students’ supervisors and tracking of the supervision process. Supervision process involves proposal development and approval; research progress monitoring; submission of dissertations for examination and tracking of dissertations under examination; and online archiving of the final dissertation after viva voce. Reminders to the respective users are automated according to the users’ feedback expectations. Most importantly, the system has inbuilt tools for reporting and analysis across the entire graduate studies spectrum. The analysis module allows for comparisons of key parameters such as completion rates and examination turnaround time, in order to gauge the performance of academic units of the institution. Initial rollout of the system at Gulu University indicates the graduate tracking system performs an oversight role that enforces stakeholders (students and supervisors) to undertake their respective tasks or risk exposure. With these insights, this paper also presents strategies for adoption of the graduate tracking system by other institutions.
Reducing Service Migrations in Fog Infrastructures by Optimizing Node Location

In order to ensure service continuity of connected cars moving inside a Fog Computing infrastructure under a Service Level Agreement, a service needs to migrate from a fog node to another. An approach is to always keep migrating the service towards the fog node that is the closest to the current position. However, frequent service migrations have a migration and network cost. Intuitively, the more migrations are triggered, the bigger this cost is. In this work we look into ways to reduce this cost by studying how to minimize the number of VM migrations triggered. We introduce a general case in which we minimize a linear combination of the infrastructure cost and the number of service migrations given statistics on the routes taken by the vehicles. This problem can be represented as a bipartite graph where the minimization problem is an instance of the Weighted Set Cover problem. For a special case of pair-wise mobility model in which the origin and destination of vehicles are in the coverage range of adjacent base stations, we first present a static offline ILP formulation of the migration minimization problem. For this simple case, we then propose two heuristics inspired by the greedy algorithm for the weighted set cover problem as polynomial approximations.
Confining the ghost in the machine: using types to secure JavaScript sandboxing

The commercial Web depends on combining content, especially advertisements, from sites that do not trust one another. Because this content can contain malicious code, several corporations and researchers have designed JavaScript sandboxing techniques (e.g., ADsafe, Caja, and Facebook JavaScript). These sandboxes depend on static restrictions, transformations, and libraries that perform dynamic checks. How can we be sure that they work? We tackle the problem of proving the security of these sandboxes. Our technique depends on creating specialized type systems to characterize the properties of the sandboxes, exploiting the structure of the checks contained in the libraries. The resulting checkers work on actual JavaScript code that is effectively unaltered; I will focus on our application to Yahoo! 's ADsafe. We establish soundness using our semantics for JavaScript, which has been tested for conformity against real implementations. Joint work with Arjun Guha, Joe Politz, and Spiros Eliopoulos.
Arc-length based Two-step Robot Motion Teaching Method for Dynamic Tasks

In this study, a new robot motion teaching method is proposed for dynamic robotic tasks. In the proposed teaching framework, the path geometry definition and timeparametrization process are separated. For the path geometry definition, waypoint-based teaching is used to secure motion accuracy and safety, and teaching-by-teleoperation is used to extract intuitive human motion easily. The direct motion dynamics transfer algorithm is developed to project the human motion dynamics into the pre-defined motion path according to the normalized arc-length of two different paths. The overall teaching procedure is empirically validated with a 6 DoF collaborative robot, and the result shows that the dynamic motion like pepper sprinkling can be easily taught by setting waypoints and swing handheld motion controller. This study suggests an intuitive and practical robot motion teaching method especially powerful for the dynamic robotic tasks.
A Residual Scheme for Digital Self-Interference Cancellation in Full Duplex Communication

Full duplex (FD) communication is one of the candidate technologies for future wireless systems due to its potential to double link data rates using the same bandwidth. Since FD radios transmit and receive at the same time in the same frequency band, the transmitted signal is obtained at the receiver end as an interference. Therefore, the self-interference (SI) signal should be canceled to enable FD communication. At high transmit power levels, nonlinear behavior of the hardware affects the SI cancellation and hence nonlinear digital cancellation is necessary to eliminate this nonlinearity. In this paper, we propose to employ linear and nonlinear digital cancellation successively. First, linear SI cancellation is completed, then nonlinear SI cancellation is utilized over the residual SI signal. The employed nonlinear cancellation algorithm is memory polynomial based. The solution is tested on a setup which includes only a real software defined radio and a single antenna as an RF equipment. In the laboratory environment tests, the proposed nonlinear cancellation provides up to 7 dB enhancement in total SI cancellation with respect to only linear digital cancellation. Moreover, the utilized FD radio set-up does not require any hardware change or circuitry modification, thus it can be adapted to any hardware which supports the same modulation scheme.
Psychophysiological Stress Profile: A Protocol to Differentiate Normal vs Pathological Subjects

OBJECTIVE: Psychophysiological stress profile examination is useful to quantify the level of individual stress reactivity. The aim of this study is to find differences between healthy subjects and subjects with psychopathological features. METHODS: We have recruited 20 healthy subjects, aged between 25 and 40 years. Subjects with a history of psychopathological episodes, epilepsy, head injuries, drug abuse were excluded. This group was compared with one group of subjects with Major Depressive Disorder (MD), one with Panic Attack Disorder (PAD) and one with Obsessive Compulsive Disorder (OCD). Assessment of the psychop hysiological stress pr ofile was performed while the participants underwent a stress test, and included the simultaneous recording of the following variables: electrodermal activity, heart rate, surface electromyogram. The schedule of the stressors was: 2 minutes base line, tactile stimulus, visual stimulation, painful stimulus, mental calculation, hyperpnoea. The total length of the profile was 30 minutes. For each variable, baseline, max value and mean value of the session were calculated and then compared across groups. RESULTS: Our study shows that healthy subjects present different profile compared to pathological subjects. CONCLUSIONS: These preliminary results suggest that
Exploration of Scenario-based Simulations for Stress Benchmarking in Swiss Public Service

Statistical interpretation of stress-related indicators collected through wearable biosensors often relies on benchmarking, especially in the context of stress management interventions. However, it remains unclear how to construct stress level benchmarks for group stress-related indicators using limited historical data. This study examines whether the method of numerical simulation of stress-related responses could contribute to constructing benchmark curves. Experimental data consists of physiological and non-physiological signals of 18 Swiss public servants collected through wearable biosensors. This study draws upon Stress Pattern Recognition algorithm and Markov Chain modeling for simulating emotional responses according to specified data-driven scenarios of high and low stress. Proposed method allows constructing benchmark curves for an Overarousal Index. Results demonstrate that numerical simulation based on small datasets can be used effectively for constructing stress level benchmarks. The findings contribute to methodological knowledge in statistical learning on Stress Pattern Recognition algorithms and Markov Chains modeling by expanding their application to a new field of emotional response simulation according to scenarios.
Phenomenology of Practice

Phenomenology of practice is formative of sensitive practice, issuing from the pathic power of phenomenological reflections. Pathic knowing inheres in the sense and sensuality of our practical actions, in encounters with others and in the ways that our bodies are responsive to the things of our world and to the situations and relations in which we find ourselves. Phenomenology of practice is an ethical corrective of the technological and calculative modalities of contemporary life. It finds its source and impetus in practical phenomenologies of reading and writing that open up possibilities for creating formative relations between being and acting, self and other, interiorities and exteriorities, between who we are and how we act.
A Survey of the Seventh International Planning Competition

In this article we review the 2011 International Planning Competition. We give an overview of the history of the competition, discussing how it has developed since its first edition in 1998. The 2011 competition was run in three main separate tracks: the deterministic (classical) track; the learning track; and the uncertainty track. Each track proposed its own distinct set of new challenges and the participants rose to these admirably, the results of each track showing promising progress in each area. The competition attracted a record number of participants this year, showing its continued and strong position as a major central pillar of the international planning research community.