Miracle-dz/UniFAR-FTUs huggingface dataset:
Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertension.

The present study was performed to determine the effects of cyclooxygenase (COX)-1 and COX-2 inhibition on blood pressure and renal hemodynamics in transgenic rats with inducible malignant hypertension [strain name: TGR(Cyp1a1Ren2)]. Male Cyp1a1-Ren2 rats (n = 7) were fed a normal diet containing the aryl hydrocarbon, indole-3-carbinol (I3C; 0.3%), for 6-9 days to induce malignant hypertension. Mean arterial pressure (MAP) and renal hemodynamics were measured in pentobarbital sodium-anesthetized Cyp1a1-Ren2 rats during control conditions, following administration of the COX-2 inhibitor nimesulide (3 mg/kg iv), and following administration of the nonspecific COX inhibitor meclofenamate (5 mg/kg iv). Rats induced with I3C had higher MAP than noninduced rats (n = 7; 188 +/- 6 vs. 136 +/- 4 mmHg, P < 0.01). There was no difference in renal plasma flow (RPF) or glomerular filtration rate (GFR) between induced and noninduced rats. Nimesulide elicited a larger decrease in MAP in hypertensive rats (188 +/- 6 to 140 +/- 8 mmHg, P < 0.01) than in normotensive rats (136 +/- 4 to 113 +/- 8 mmHg, P < 0.01). Additionally, nimesulide decreased GFR (0.9 +/- 0.13 to 0.44 +/- 0.05 ml.min(-1). g(-1), P < 0.05) and RPF (2.79 +/- 0.27 to 1.35 +/- 0.14 ml.min(-1). g(-1), P < 0.05) in hypertensive rats but did not alter GFR or RPF in normotensive rats. Meclofenamate further decreased MAP in hypertensive rats (to 115 +/- 10 mmHg, P < 0.05) but did not decrease MAP in normotensive rats. Meclofenamate did not alter GFR or RPF in either group. These findings demonstrate that COX-1- and COX-2-derived prostanoids contribute importantly to the development of malignant hypertension in Cyp1a1-Ren2 transgenic rats. The data also indicate that COX-2-derived vasodilatory metabolites play an important role in the maintenance of RPF and GFR following induction of malignant hypertension in Cyp1a1-Ren2 transgenic rats.
Index Coding With Erroneous Side Information

In this paper, new index coding problems are studied, where each receiver has erroneous side information. Although side information is a crucial part of index coding, the existence of erroneous side information has not been considered yet. We study an index code with receivers that have erroneous side information symbols in the error-free broadcast channel, which is called an index code with side information errors (ICSIE). The encoding and decoding procedures of the ICSIE are proposed, based on the syndrome decoding. Then, we derive the bounds on the optimal codelength of the proposed index code with erroneous side information. Furthermore, we introduce a special graph for the proposed index coding problem, called a <inline-formula> <tex-math notation="LaTeX">$\delta _{s}$ </tex-math></inline-formula>-cycle whose properties are similar to those of the cycle in the conventional index coding problem. Properties of the ICSIE are also discussed in the <inline-formula> <tex-math notation="LaTeX">$\delta _{s}$ </tex-math></inline-formula>-cycle and clique. Finally, the proposed ICSIE is generalized to an index code for the scenario having both additive channel errors and side information errors, called a generalized error correcting index code.
The capBCA Locus is Required for Intracellular Growth of Francisella tularensis LVS

Francisella tularensis is the causative agent of tularemia and a category A bioterrorism agent. The molecular basis for the extreme virulence of F. tularensis remains unclear. Our recent study found that capBCA, three neighboring genes, are necessary for the infection of F. tularensis live vaccine strain (LVS) in a respiratory infection mouse model. We here show that the capBCA genes are necessary for in vivo growth of F. tularensis LVS in the lungs, spleens, and livers of BALB/c mice. Unmarked deletion of capBCA in type A strain Schu S4 resulted in significant attenuation in virulence although the level of the attenuation in Schu S4 was much less profound than in LVS. We further demonstrated that CapB protein is produced at a low level under the in vitro culture conditions, and capB alone is necessary for in vivo growth of F. tularensis LVS in the lungs of BALB/c mice. Finally, deletional mutations in capB alone or capBCA significantly impaired intracellular growth of F. tularensis LVS in cultured macrophages, thus suggesting that the capBCA genes are necessary for intracellular adaptation of F. tularensis. The requirement of this gene locus in intracellular adaption at least in part explains the significant attenuation of F. tularensis capBCA mutants in virulence.
Distributed Analog Channel Coding for Wireless Relay Networks

Distributed coding has been shown to be an efficient scheme to improve the performance of wireless relay networks. In this paper we propose an analog distributed channel coding (ADC) scheme. In the proposed scheme, the intermediate relays directly process the received analog noisy signals without making the hard estimation and performs analog channel encoding of the noisy soft estimates of the transmitted symbols, so that the processed signals forwarded by all relays can form an analog distributed convolutional codeword. Assuming the source packet is encoded by a channel code, the ADC scheme can form serial concatenated codes and iterative decoding can be applied at the destination. We compare our proposed scheme with other existing schemes under Additive White Gaussian Noise (AWGN) and fast Rayleigh fading channel and validate the simulation results with the aid of Extrinsic Information Transfer (EXIT) chart analysis. Simulation results show that the proposed ADC scheme can effectively overcome the error propagation due to the erroneous decoding at the relay in the conventional decodeforward (DF) scheme and provide considerable coding gains, thus considerably outperforming the conventional soft information relaying protocols. The coding gains increase as the number of state in the relay encoder increases.
Less Is More: Substrate Reduction Therapy for Lysosomal Storage Disorders

Lysosomal storage diseases (LSDs) are a group of rare, life-threatening genetic disorders, usually caused by a dysfunction in one of the many enzymes responsible for intralysosomal digestion. Even though no cure is available for any LSD, a few treatment strategies do exist. Traditionally, efforts have been mainly targeting the functional loss of the enzyme, by injection of a recombinant formulation, in a process called enzyme replacement therapy (ERT), with no impact on neuropathology. This ineffectiveness, together with its high cost and lifelong dependence is amongst the main reasons why additional therapeutic approaches are being (and have to be) investigated: chaperone therapy; gene enhancement; gene therapy; and, alternatively, substrate reduction therapy (SRT), whose aim is to prevent storage not by correcting the original enzymatic defect but, instead, by decreasing the levels of biosynthesis of the accumulating substrate(s). Here we review the concept of substrate reduction, highlighting the major breakthroughs in the field and discussing the future of SRT, not only as a monotherapy but also, especially, as complementary approach for LSDs.
Great experiments in psychology

COURSE OUTLINE : Psychology as a subject interests many but what is popularly known are the common views that humans hold about their race. Over the century, the subject’s endevour to establish itself as a science through various experiments remains unknown to many. The present course attempts to share the most important experiments in the history of Psychology that has helped shape its identity. It aims to aid students’ understanding of how to design experiments with human subjects and assist the student to understand Psychology with a scientific eye.
Working Conditions and Individual Differences Are Weakly Associated with Workaholism: A 2-3-Year Prospective Study of Shift-Working Nurses

This study focuses on individual differences and the demand-support-control model in relation to workaholism. We hypothesized that unfavorable working conditions (high job demands, low job control/decision latitude, and low social support at work) and individual differences concerning sleep/wake-related variables (high flexibility, high morningness, and low languidity) would be related to workaholism measured 2–3 years later. Survey data stemmed from a prospective cohort of shift-working nurses (N = 1,308). The results showed that social support at work was negatively related to workaholism, whereas job demands were positively related to workaholism. Flexibility in terms of time for working/sleeping was also positively related to workaholism. The analyses further revealed that workaholism was inversely associated with age as well as having a child or having a child move in. Conjointly, the independent variables explained 6.4% of the variance in workaholism, while their relative importance was small overall. After controlling for all other independent variables, high job demands had the strongest relationship (small-to-medium) with workaholism. This implies that less pressure from the external environment to work excessively hard may prevent an increase in workaholic behaviors. Overall, the study adds to our understanding of the relationships between working conditions, individual differences, and workaholism.
A Review of Corpus-based Statistical Models of Language Variation

This paper is a brief review of the research on language variation using corpus data and statistical modeling methods. The variation phenomena covered in this review include phonetic variation (in spontaneous speech) and syntactic variation, with a focus on studies of English and Chinese. The goal of this paper is to demonstrate the use of corpus-driven statistical models in the study of language variation, and discuss the contribution and future directions of this line of research.
Psicologia animal no Brasil: o fundador e a fundação

This paper describes the personal and professional trajectory of Prof. Walter Hugo de Andrade Cunha, who introduced Animal Psychology and Ethology in Brasil, and the course of their development and unfolding since then, in terms of teaching and research. The sources of information were interviews with Prof. Cunha and with some of his students, and files on the research production and on the careers of former students of Prof. Cunha and of their graduate students. We suggest relations between the personal and professional life history of Prof. Cunha to illustrate the evolution of his theorization in Psychology and of the method he created to teach and to supervise and to clarify his role in the diffusion of Animal Psychology and of Ethology in Brazil. The paper includes two bibliographies, relative to Prof. Cunha's own production and to his students' production of Master and Doctoral dissertations.
Improved BOF Method for Person Re-Identification

Feature representation and matching are two challenging problems for person e-identification problem. Designing a suitable feature representation method, and the according high efficiency matching scheme is meaningful. In this paper, a new person re-identification method was put forward. First, an improved BOF method was proposed, it use SURF algorithm to extract the preliminary feature and generate visual dictionary. And then, an effective classifier was designed by LIBSVM technology. This method can deal with illumination and scale invariants, and improve the efficiency of the matching process. The experimental results show that it is an effective scheme for person re-identification.
Cd169 + Macrophages Provide a Niche Promoting Erythropoiesis under Homeostasis, Myeloablation and in Jak2v617f-induced Polycythemia Vera Hhs Public Access

The role of macrophages in erythropoiesis was suggested several decades ago with the description of " erythroblastic islands " in the bone marrow (BM) composed of a central macrophage surrounded by developing erythroblasts. However, the in vivo role of macrophages in erythropoiesis under homeostasis or disease remains unclear. Specific depletion of CD169 + macrophages markedly reduced erythroblasts in the BM but did not result in overt anemia under homeostasis likely due to concomitant alterations in RBC clearance. However, CD169 + macrophage depletion significantly impaired erythropoietic recovery from hemolytic anemia, acute blood loss and myeloablation. Furthermore, macrophage depletion normalized the erythroid compartment in a JAK2 V617F-driven murine model of polycythemia vera (PV), suggesting that erythropoiesis in PV, unexpectedly, remains under the control of macrophages in the BM and splenic microenvironments. These data indicate that CD169 + macrophages promote late erythroid Users may view, print, copy, download and text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: provided feedback on the manuscript. N.vR provided clodronate liposomes and feedback on the manuscript. M.T. , Z.J.Z. provided mice and feedback on the manuscript. A.B. designed the mathematical model of steady-state erythropoiesis and provided feedback on the manuscript.
Analysis of the harmonized growth pattern of fetal organs by multidimensional scaling and hierarchical clustering

The development of an organ may be affected by various growth and differentiation factors released from other organs. These factors are believed to have important effects on the development of multiple organs. To detect and analyze harmonized development among multiple organs, similarities in growth patterns among fetal organs were examined using multivariate analysis. Ninety human fetuses obtained from the Kyoto Collection of Human Embryos were dissected. Harmonized development of organs was evaluated by multidimensional scaling and cluster analysis using measurements (length, width, height, and weight) of the fetal organs. Similar growth patterns were observed between the brain, including cerebrum, diencephalon, and midbrain (cerebrum‐to‐midbrain [Cer‐Mid]), and pituitary (crown‐rump length [CRL] 95–155 mm). Further, similar growth patterns were observed between the liver and Cer‐Mid and cerebellum (Cb; CRL 156–202 mm), and between Cer‐Mid and Cb (CRL 203–253 mm). Similarities in growth patterns were also observed between right and left lungs (CRL 99–235 mm) and between the aorta and heart (CRL 139–187 mm), but not between the lung and pulmonary trunk. These findings revealed synchronized development among fetal organs and suggested a functional and structural relationship among different organs in the prenatal period. These relationships include the existence of common factors in organ development, such as cross‐talk mediated by humoral factors, and the presence of an anatomical and functional relationship in the fetal circulatory system.
The Effects of SST-Induced Surface Wind Speed and Direction Gradients on Midlatitude Surface Vorticity and Divergence

Abstract The effects of surface wind speed and direction gradients on midlatitude surface vorticity and divergence fields associated with mesoscale sea surface temperature (SST) variability having spatial scales of 100–1000 km are investigated using vector wind observations from the SeaWinds scatterometer on the Quick Scatterometer (QuikSCAT) satellite and SST from the Advanced Microwave Scanning Radiometer for Earth Observing System (AMSR-E) Aqua satellite. The wind–SST coupling is analyzed over the period June 2002–August 2008, corresponding to the first 6+ years of the AMSR-E mission. Previous studies have shown that strong wind speed gradients develop in response to persistent mesoscale SST features associated with the Kuroshio Extension, Gulf Stream, South Atlantic, and Agulhas Return Current regions. Midlatitude SST fronts also significantly modify surface wind direction; the surface wind speed and direction responses to typical SST differences of about 2°–4°C are, on average, about 1–2 m s−1 and 4°.
Teaching system for multifingered robot hands using kinetic information of manipulated objects

This paper proposes a teaching system for multi-fingered robot hands by using kinetic information of target objects with visual feedback. The purpose of this system is to operate multi-fingered robot hands with high DOF mechanisms intuitively and effectively. The system calculates the appropriate trajectory of the fingers according to the kinetic information of the target object under the twist rolling contact constraint. In addition, force and visual feedback control is adopted for more accurate and stable manipulation. This paper describes the results of the experiments by using the developed teaching system, and the future works to be improved are discussed.
Truth to Process - Evolutionary Art and the Aesthetics of Dynamism

After a great deal of initial promise and enthusiasm, evolutionary art seems to have hit a premature and disappointing plateau. This paper proposes a difficult but necessary program for the advancement of evolutionary art. First two significant problems are discussed. The first is the problem of creating aesthetic fitness functions that would allow evolutionary art systems to execute unattended with industrial sized populations and generations. In this context a quick survey of computational aesthetic evaluation is offered. Then it is suggested that progress in perceptual psychology and neuroaesthetics, coupled with advancements in connectionist computing, may provides new techniques for scoring aesthetic fitness. The second problem is the sense of “sameness” and lack of innovation exhibited by typical evolutionary art systems. In this regard the related technical problem of genetic representation is noted, various types of genetic representation are reviewed, and a critique is offered relative to evolution in nature. It is noted that evolution in exercises multiple levels of complexification and emergence. Finally an implication for generative art aesthetics and theory is discussed. It is suggested that current evolutionary art systems and projects are incoherent in so far as they don’t focus on the essential virtue of generative art, i.e. a focus on process rather than final form. It is suggested that the general shift from nouns to verbs that is essential to generative art should be pushed to the fore. An aesthetic of truth to process and dynamism is proposed as foundational for evolutionary art.
Extracting daily patterns of human activity using non-negative matrix factorization

This paper presents an algorithm to mine basic patterns of human activities on a daily basis using non-negative matrix factorization (NMF). The greatest benefit of the algorithm is that it can elicit patterns from which meanings can be easily interpreted. To confirm its performance, the proposed algorithm was applied to PC logging data collected from three occupations in offices. Daily patterns of software usage were extracted for each occupation. Results show that each occupation uses specific software in its own time period, and uses several types of software in parallel in its own combinations. Experiment results also show that patterns of 144 dimension vectors were compressible to those of 11 dimension vectors without degradation in occupation classification performance. Therefore, the proposed algorithm compressed basic software usage patterns to about one-tenth of their original dimensions while preserving the original information. Moreover, the extracted basic patterns showed reasonable interpretation of daily working patterns in offices.
How Best to Disagree in Order to Agree?

We propose a new noncooperative approach to implement a cooperative bargaining solution. This approach relies on a mechanism which specifies what happens when, at the end of the bargaining phase, players’ propositions are still not compatible. The mechanism uses a random lottery and the history of proposals. At equilibrium, under the threat of this mechanism, provided that the use of it carries a small cost, players reach consensus after a finite number of proposals. No discounting is needed. The equilibrium strategies implement the full Raiffa bargaining process and players agree on a solution arbitrarily close to the Raiffa solution.
A Principled Approach to Developing New Languages for Live Coding

This paper introduces Improcess, a novel cross-disciplinary collaborative project focussed on the design and development of tools to structure the communication between performer and musical process. We describe a 3-tiered architecture centering around the notion of a Common Music Runtime, a shared platform on top of which inter-operating client interfaces may be combined to form new musical instruments. This approach allows hardware devices such as the monome to act as an extended hardware interface with the same power to initiate and control musical processes as a bespoke programming language. Finally, we reect on the structure of the collaborative project itself, which offers an opportunity to discuss general research strategy for conducting highly sophisticated technical research within a performing arts environment such as the development of a personal regime of preparation for performance.
12. Undergraduate Essay Writing: Online and Face-to-Face Peer Reviews

We implemented two different approaches of using peer review to support undergraduate essay assignments for students taking large second-year courses in life sciences and biology: a web-based online peer review (OPR) approach and a more traditional face-to-face peer review (FPR) approach that was conducted in tutorial settings. The essays consisted of a review of current literature to discuss the molecular involvement of cancer development or stem-cell growth. Following implementation of the peer reviews, we conducted a preliminary analysis of the pros and cons of using the two methods. Student and instructor feedback suggested that the activity of peer review was generally perceived as valuable regardless of which approach was used. OPR was convenient and saved time and resources relative to FPR, but the technical drawbacks using the OPR approach made it challenging for some students to use. A subsequent investigation using alternative OPR programs that offer additional functionality is planned.
Mammary development in the embryo and adult: a journey of morphogenesis and commitment

Mammary gland development occurs through distinctive stages throughout embryonic and pubertal development and reproductive life. At each stage, different signals are required to induce changes in both the epithelium and the surrounding mesenchyme/stroma. Recent studies have provided new insights into the origin, specification and fate of mammary stem and progenitor cells and into how the differentiated lineages that comprise the functional mammary gland are determined. The development of new tools and culture techniques has also enabled the factors that influence branching morphogenesis in the embryonic and pubertal gland to be identified. A surprising recent discovery has been that mammary epithelial cells commit to differentiated lineages using the same signalling pathways that regulate lineage determination in T helper cells.