Miracle-dz/UniFAR-FTUs huggingface dataset:
Loss of cyclin D1 does not inhibit the proliferative response of mouse liver to mitogenic stimuli

Cyclin D1 is considered to play a critical role in the progression from G1 to S phase of the cell cycle, and its overexpression is seen in many human tumors. However, previous studies in cell lines have shown that cyclin D1 is not sufficient to trigger cell replication. To directly test the role of cyclin D1 in the progression of the cell cycle, we have examined the proliferative response of hepatocytes to the hepatomitogen 1,4‐bis[2‐(3,5‐dichloropyridyloxy)]benzene (TCPOBOP) in mice with homozygous disruption of the cyclin D1 gene. We found that 24 hours after administration of TCPOBOP, the number of bromodeoxyuridine (BrdU)‐positive hepatocytes was significantly reduced in cyclin D1−/− (labeling index was 1.9% in knockout mice vs. 9.7% of heterozygous mice); however, no difference in the number of proliferating hepatocytes was found 36 or 72 hours after treatment (labeling index was 16% and 43% in cyclin D1−/− mice vs. 20% and 41% of heterozygous mice), indicating that lack of cyclin D1 may transiently delay entry into S phase but is not sufficient to inhibit the response of hepatocytes to mitogenic stimuli. The results also show that although there was no difference in hepatic protein levels of cyclin D2 and D3 between untreated cyclin D1−/− and cyclin D1+/− mice, messenger RNA (mRNA) and protein levels of cyclin E were much higher in the former. In conclusion, our results show that cyclin D1 is not essential for liver development and hepatocyte proliferation induced by mitogenic stimuli and suggest that overexpression of cyclin E may compensate for the lack of cyclin D1. (HEPATOLOGY 2002;36:1098‐1105.)
Niederschlagsschwellenwerte bei der Auslösung von Muren

Die zentrale Hypothese dieser Arbeit lautete, dass die Auslosung von Muren im Vinschgau an Niederschlagsschwellenwerte gekoppelt ist, die mithilfe von statistischen Modellen berechnet werden konnen. Im Rahmen dieser Arbeit wurden Niederschlagsschwellenwerte fur die Auslosung von Muren mithilfe des Antecedent Daily Rainfall Models nach GLADE et al. (2000) fur den Vinschgau errechnet. Das Modell fur den Zeitraum von 1920 bis 2007 lieferte keine realistischen Resultate. Einerseits gab es sehr viele Tage mit hohen Niederschlagswerten, an denen keine Mure beobachtet werden konnte und andererseits gab es viele Tage mit niedrigen oder gar keinen Niederschlagen, an denen eine Mure beobachtet wurde. Das liegt daran, dass einerseits nicht alle aufgetretenen Muren beobachtet werden konnten und andererseits dass nicht alle lokalen Niederschlage durch das Netz der Wetterstationen aufgezeichnet werden konnten. Um das Modell zu verbessern, wurde es nochmals nur fur den Zeitraum von 1998 bis 2007 erstellt, da die Aufzeichnung der Muren ab 1998 durch die Einfuhrung eines standardisierten Formulars verbessert wurde. Die Ergebnisse fur diesen Zeitraum waren realistischer. Es wurde im Rahmen dieser Arbeit bewiesen, dass das Antecedent Daily Rainfall Modell fur Muren angewendet werden kann. Letztendlich konnte gezeigt werden, dass im Vinschgau der Niederschlag, der am Tag der Mure fallt, wesentlich wichtiger fur die Auslosung ist, als der vorangegangene Niederschlag. Daruber hinaus konnen die Erkenntnisse dieser Arbeit zu einer verbesserten Anwendung des Antecedent Daily Rainfall Modells fur Muren beitragen. Mit einer gezielten Verbesserung der Daten, kann das Modell durchaus als Grundlage zur Konzeption von Fruhwarnsystemen fur Muren dienen, indem es realistische Niederschlagsschwellenwerte liefert.
Designing variability tolerant logic using evolutionary algorithms

This paper describes an approach to create novel, robust logic-circuit topologies, using several evolution-inspired techniques over a number of design stages. A library of 2-input logic gates are evolved and optimised for tolerance to the effects of intrinsic variability. Block-level designs are evolved using evolutionary methods (CGP). A method of selecting the optimal gates from the library to fit into the block-level designs to create variability-tolerant circuits is also proposed.
Acetic acid removal from corn stover hydrolysate using ethyl acetate and the impact on Saccharomyces cerevisiae bioethanol fermentation

Acetic acid is introduced into cellulose conversion processes as a consequence of composition of lignocellulose feedstocks, causing significant inhibition of adapted, genetically modified and wild‐type S. cerevisiae in bioethanol fermentation. While adaptation or modification of yeast may reduce inhibition, the most effective approach is to remove the acetic acid prior to fermentation. This work addresses liquid–liquid extraction of acetic acid from biomass hydrolysate through a pathway that mitigates acetic acid inhibition while avoiding the negative effects of the extractant, which itself may exhibit inhibition. Candidate solvents were selected using simulation results from Aspen Plus™, based on their ability to extract acetic acid which was confirmed by experimentation. All solvents showed varying degrees of toxicity toward yeast, but the relative volatility of ethyl acetate enabled its use as simple vacuum evaporation could reduce small concentrations of aqueous ethyl acetate to minimally inhibitory levels. The toxicity threshold of ethyl acetate, in the presence of acetic acid, was found to be 10 g L−1. The fermentation was enhanced by extracting 90% of the acetic acid using ethyl acetate, followed by vacuum evaporation to remove 88% removal of residual ethyl acetate along with 10% of the broth. NRRL Y‐1546 yeast was used to demonstrate a 13% increase in concentration, 14% in ethanol specific production rate, and 11% ethanol yield. This study demonstrated that extraction of acetic acid with ethyl acetate followed by evaporative removal of ethyl acetate from the raffinate phase has potential to significantly enhance ethanol fermentation in a corn stover bioethanol facility. © 2016 American Institute of Chemical Engineers Biotechnol. Prog. , 32:929–937, 2016
Title Mutations in Ran system affected telomere silencing in Saccharomycescerevisiae

*KURAに登録されているコンテンツの利用については,著作権法に規定されている私的使用や引用などの範囲内で行ってください。 *著作権法に規定されている私的使用や引用などの範囲を超える利用を行う場合には,著作権者の許諾を得てください。 ただし,著作権者 から著作権等管理事業者(学術著作権協会,日本著作出版権管理システムなど)に権利委託されているコンテンツの利用手続については ,各著作権等管理事業者に確認してください。 Title Mutations in Ran system affected telomere silencing in Saccharomyces cerevisiae Author(s) Hayashi, Naoyuki; Kobayashi, Masahiko; Shimizu, Hiroko; Yamamoto, Ken-ichi; Murakami, Seishi; Nishimoto, Takeharu Citation Biochemical and Biophysical Research Communications, 363(3): 788-794
Multi-Arm Active Transfer Learning for Telugu Sentiment Analysis

Transfer learning algorithms can be used when sufficient amount of training data is available in the source domain and limited training data is available in the target domain. The transfer of knowledge from one domain to another requires similarity between two domains. In many resource-poor languages, it is rare to find labeled training data in both the source and target domains. Active learning algorithms, which query more labels from an oracle, can be used effectively in training the source domain when an oracle is available in the source domain but not available in the target domain. Active learning strategies are subjective as they are designed by humans. It can be time consuming to design a strategy and it can vary from one human to other. To tackle all these problems, we design a learning algorithm that connects transfer learning and active learning with the well-known multi-armed bandit problem by querying the most valuable information from the source domain. The advantage of our method is that we get the best active query selection using active learning with multi arm and distribution matching between two domains in conjunction with transfer learning. The effectiveness of the proposed method is validated by running experiments on three Telugu language domain-specific datasets for sentiment analysis.
An Address ON ACUTE ABDOMINAL SYMPTOMS

PERHAPS there is no more difficult and responsible that a medical practitioner can be placed fronted. with a case presenting the characteristics we, may call an" acute abdominal illness " ; an illness with an acute onset of which symptoms are severe abdominal pain, vomiting, less collapse. In such cases the medical as, quickly as possible to some conclusion, firstly, is the matter with the patient, -and secondly, bility of immediate operative interference. of cases it is not possible to make an exact the;
A Graph-Partitioning Based Approach for Parallel Best-First Search

Parallel best-first search algorithms such as HDA* distribute work among the processes using a global hash function. Previous work distribution strategies seek to find a good walltime efficiency by reducing search overhead and/or communication overhead, but there was no unified, quantitative analysis on the effects of the methods on both overheads. We propose GRAZHDA*, a graph-partitioning based approach to automatically generating feature projection functions. GRAZHDA* seeks to approximate the partitioning of the actual search space graph by partitioning the domain transition graph, an abstraction of the state space graph. We evaluate GRAZHDA* on domain-independent planning as well as a domain specific solver for the 24-puzzle and show that GRAZHDA* outperforms previous methods.
Maturation of 23S rRNA in Bacillus subtilis in the Absence of Mini-III

ABSTRACT 23S rRNA maturation in Bacillus subtilis is catalyzed by the recently characterized enzyme Mini-RNase-III. Mini-III is dispensable, however, and 23S rRNA is matured by other ribonucleases in strains lacking this enzyme. Here we show that these RNases are the 5′-to-3′ exoribonuclease RNase J1 and the 3′-to-5′ exoribonucleases, principally RNase PH and YhaM.
Thinned fiber Bragg gratings as high sensitivity refractive index sensor

In this work, the numerical and experimental analysis on the use of thinned fiber Bragg gratings as refractive index sensors have been carried out. Wet chemical etching in a buffered hydrofluoric acid solution was used for sensor fabrication. Experimental characterization for an almost full etched cladding sensor is presented demonstrating good agreement with numerical results and resolutions of /spl ap/10/sup -5/ and /spl ap/10/sup -4/ for outer refractive index around 1.45 and 1.333, respectively.
Use of health services by previously uninsured Medicare beneficiaries.

BACKGROUND Previously uninsured adults who enroll in the Medicare program at the age of 65 years may have greater morbidity, requiring more intensive and costlier care over subsequent years, than they would if they had been previously insured. METHODS We used longitudinal data from the nationally representative Health and Retirement Study to assess self-reported health care use and expenditures from 1992 through 2004 among 5158 adults who were privately insured or uninsured before Medicare coverage began at the age of 65 years. We used propensity-score methods to compare health care use and expenditures for previously insured and uninsured beneficiaries who were similar across numerous characteristics at 59 to 60 years of age and adjusted for differences in supplemental and prescription-drug coverage after 65 years of age. RESULTS Among 2951 adults with hypertension, diabetes, heart disease, or stroke diagnosed before 65 years of age, previously uninsured adults who acquired Medicare coverage at the age of 65 reported significantly greater increases in the numbers of doctor visits (P<0.001) and hospitalizations (P=0.001) and in total medical expenditures (P=0.02) than did previously insured adults. Significant differential increases were not evident among the 2207 adults without these conditions (P>0.12 for all comparisons). In analyses adjusted for supplemental and prescription-drug coverage, previously uninsured adults with these conditions reported more doctor visits (13% relative difference, P=0.04), more hospitalizations (20% relative difference, P=0.04), and higher total medical expenditures (51% relative difference, P=0.09) from ages 65 to 72 years than did previously insured adults. CONCLUSIONS The costs of expanding health insurance coverage for uninsured adults before they reach the age of 65 years may be partially offset by subsequent reductions in health care use and spending for these adults after the age of 65, particularly if they have cardiovascular disease or diabetes before the age of 65 years.
Modulatory effects of naringin on hepatic key enzymes of carbohydrate metabolism in high fat diet fed-low dose of streptozotocin-induced diabetic rats

We evaluated the modulatory effects of naringin on altered hepatic key enzymes of carbohydrate metabolism in high fat diet fedlow dose of streptozotocin induced diabetic rats. Oral treatment of naringin at a doses of 20, 40 and 80 mg/kg body weight to diabetic rats for 30 days resulted in a significant reduction in the levels of plasma glucose, blood glycosylated hemoglobin and increase in the levels of plasma insulin and blood hemoglobin. The altered activities of the hepatic key enzymes of carbohydrate metabolism such as hexokinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase, glycogen phosphorylase and glycogen content of diabetic rats were significantly reverted to near normal levels by the treatment of naringin in a dose dependent manner. Naringin at a dose of 80 mg/kg body weight showed the highest significant effect than the other two doses. Further, immunohistochemical observation of pancreas revealed that naringin treated diabetic rats showed increased insulin immunoreactive β-cells, which confirmed the biochemical findings. These findings revealed that naringin has potential antihyperglycemic activity in high fat diet fedlow dose of streptozotocin-induced diabetic rats.
Segmentation of non-rigid bodies in affine motion: a new framework

In this paper a new technique for partitioning a non-rigid body (human body), when it is in affine motion is presented. The technique is based on finding the contour in the "modified difference frame". These contours can then be used in identifying the regions of interest. Results show that the technique eliminates a lot of stationary regions and thus can reduce the amount of computational time required for the processing of the image. It reduces significantly the total bit rate required for transmission. It also provides an algorithm for contour tracing using extended boundary concept and contour compression by contour merging.
Denial of pregnancy ‐ characteristics of women at risk

Background. Denial of pregnancy is a woman's subjective lack of awareness of being pregnant. Denial throughout most of gestation or until delivery may be associated with significant risks for both mother and fetus. We wanted to investigate if maternal characteristics were useful in order to identify women at risk. Methods. A 1‐year prospective study was performed to recruit all women with denied pregnancies in Berlin, Germany. Maternal parameters were analysed and sociodemographic variables were compared with the regional birth register. Results. Sixty‐five women were recruited. Maternal age was between 15 and 44 years (median 27 years). Only 21 women had never been pregnant before. A large majority (83%) had a close partner. Three women had a psychiatric diagnosis of schizophrenia, and only one a current abuse of analgesics/tranquilizer. Conclusions. The group of women with denied pregnancy was heterogeneous, and a clear‐cut typology of a ‘pregnancy denier’ could not be established.
The Prevalence and Distribution of Aging-Friendly Human Resource Practices

The aging of the workforce in the developed world has prompted organizations to implement human resource (HR) policies and practices encouraging older workers to defer retirement. However, little is known about the prevalence of such practices, and the organizational factors associated with their adoption. In this study, we used data collected from 2008 to 2009 from a national probability sample of retirement eligible workers in the United States (N = 407) to assess the prevalence of aging-friendly human resource practices (AFHRP), and their organizational predictors. Results indicate that employee wellness programs, unpaid leave, and reassignment based on physical needs are among the most prevalent AFHRP. However, in the vast majority of enterprises, AFHRP are limited. Results also indicate that projected organizational growth and a focus on internal labor market practices are positively associated with the adoption of AFHRP. Organizational size and the degree of unionization, while positively associated with aging-friendly benefits, were inversely associated with flexibility practices.
Diagnostic Accuracy of Transthoracic Echocardiography to Predict Fluid Responsiveness by Passive Leg Raising in the Critically Ill: A Meta-Analysis

Background: Hemodynamic instability is common in critical patients and not all patients respond to fluid challenge, so we need accurate and rapid hemodynamic techniques to help the clinicians to guide fluid treatment. Numerous hemodynamic techniques have been used to predict fluid responsiveness till now. Transthoracic echocardiography (TTE) appears to have the ability to predict fluid responsiveness, but there is no consensus on whether it can be used by passive leg raising (PLR). Methods: We performed a literature search using MEDLINE (source PubMed, from 1947), EMBASE (from 1974) and the Cochrane Database of Systematic Reviews for prospective studies with no restrictions. Pooled effect estimates were obtained by using random-effects meta-analysis. Results: 7 prospective studies involving 261 patients and 285 boluses were identified. The pooled sensitivity and specificity of TTE are 86% (79% - 91%) and 90% (83% - 94%), respectively. The summary receiver operating characteristic (sROC) curve shows an optimum joint sensitivity and specificity of 0.88, with area under the sROC curve (AUC) of 0.94. The result of diagnostic odds ratio (DOR) is 50.62 (95% confidence interval [CI]: 23.70 - 108.12). The results of positive likelihood ratio (+LR) and negative likelihood ratio (? LR) are 7.07 (95% CI: 4.39 - 11.38) and 0.19 (95% CI: 0.13 - 0.28), which indicated strong diagnostic evidence. Conclusions: TTE is a repeatable and reliable noninvasive tool to predict fluid responsiveness in the critically ill during PLR with good test performance. This meta-analysis brings evidence to employ well-trained clinician-echocardiographers to assess patients’ volume statue via TTE to benefit daily work in intensive care units (ICUs).
Detecting Specular Propagation Paths in the Presence of Distributed Scattering in Angle and Delay Domains

In this paper, we derive a method for the detection and estimation of specular propagation paths that takes the correlation in both, angle and delay domain, of the distributed scattering into account. The method is based on an iterative procedure that alternates between the estimation of specular paths and of distributed scattering. The computational complexity is reduced compared to deterministic methods, which are based on the estimation of parameters of a large number of specular paths. The results show that the proposed method is able to detect and estimate the propagation parameters of specular paths that have low power, which would not be distinguished from distributed scattering by existing techniques.
Assessment of Trace-Di ff erences in Timing Analysis for Complex Real-Time Embedded Systems

In this paper, we look at identifying temporal differences between different versions of Complex Real-Time Embedded Systems (CRTES) by using timing traces representing response times and execution times of tasks. In particular, we are interested in being able to reason about whether a particular change to CRTES will impact on their temporal performance, which is difficult to answer due to the complicated timing behavior such CRTES have. To be specific, we first propose a sampling mechanism to eliminate dependencies existing in tasks’ response time and execution time data in the traces taken from CRTES, which makes any statistical inference in probability theory and statistics realistic. Next, we use a mature statistical method, i.e., the nonparametric two-sample Kolmogorov-Smirnov test, to assess the possible temporal differences between different versions of CRTES by using timing traces. Moreover, we introduce a method of reducing the number of samples used in the analysis, while keeping the accuracy of analysis results. This is not trivial, as collecting a large amount of samples in terms of executing real systems is often costly. Our evaluation using simulation models describing an industrial robotic control system with complicated tasks’ timing behavior, indicates that the proposed method can successfully identify temporal differences between different versions of CRTES, if there is any. Furthermore, our proposed method outperforms the other statistical methods, e.g., bootstrap and permutation tests, that are often widely used in contexts, in terms of bearing on the accuracy of results when other methods have failed.
Ethnic Discrimination in the Greek Labour Market: Occupational Access, Insurance Coverage and Wage Offers

By means of a field experiment we investigate whether low-skilled male Albanians face discrimination in the Greek labour market. To test for discrimination in occupational access, curriculum vitae which differed only in ethnicity were faxed to firms. The probability for Albanians to receive an interview is lower than for Greeks by 21.4 percentage points. Furthermore, by exploiting the informal wage and insurance coverage offers on the part of employers, we find a wage discrimination factor of 11 per cent against the Albanians, while their probability of being registered with insurance is 25.7 percentage points lower than that for Greeks.
Serially concatenated continuous phase modulation with iterative decoding

Serially concatenated continuous phase modulation (SCCPM), or coded and interleaved CPM, is examined. Like turbo codes, SCCPM allows for iterative decoding based on a posteriori probability algorithms. The system is analyzed through an upper bound on the average bit error probability with maximum likelihood sequence detection, showing that SCCPM is capable of providing interleaver gain - and thus turbo-like performance - if a proper mapping of the CPM symbols is used. Simulations indicate that firstly, the analysis gives a satisfactory view of system performance when equal outer codes are used, and secondly, that remarkably good performance can be obtained with some simple systems. For unequal outer codes, the convergence of the iterative decoder will also have a significant effect on performance. Finally, a bandwidth/performance comparison of some selected systems shows that SCCPM can achieve large gains compared to the best known coded CPM systems without interleaving. Keywords: concatenated codes; serial concatenation; continuous phase modulation; iterative decoding; APP algorithm
1-[2-(4-nitrophenoxy)acetyl]pyrrolidin-2-one: an antiamnesic agent.

The title compound, C(12)H(12)N(2)O(5), is a potential antiamnesic agent. The pyrrolidinone ring has an envelope conformation, and the central moiety is almost coplanar with the planes of the phenyl and pyrrolidinone rings. In the crystal structure, weak intermolecular C--H.O interactions link the molecules into a complex network that can be described by R(2)(2)(X) rings (X = 16, 20 and 26) and a C(12) chain.