Miracle-dz/UniFAR-FTUs huggingface dataset:
THE EFFECT OF CHLORPROMAZINE ON NICOTINAMIDE METHYLPHERASE: AN EXAMPLE OF DRUG‐ENZYME INTERACTION AT THE MOLECULAR LEVEL *

Elsewhere in this monograph, R. G. Grenell' discusses the possibility that altered or improperly formed molecules, such as protein molecules, would have altered properties and might represent an underlying defect in mental disease. Examples of this type of defect are known in certain other diseases; sickle-cell anemia is a classic example.2 We propose to discuss a molecular biological effect of a drug of wide interest to other contributors to this publication, namely chlorpromazine. In studying a biochemical effect common to many tranquilizing agents, that is, the ability to maintain nicotinamide-elevated pyridine nucleotide content of l i ~ e r , ~ ~ it was observed that chlorpromazine could inhibit the enzyme nicotinamide methylpherase6 (R. Salvador and R. M. Burton, in preparation). This effect could be demonstrated when the drug was administered to the mice or rats in vivo prior to the partial purification of the enzyme and also by adding the chlorpromazine during the in vitro assay of the enzyme preparation from untreated animals. The nicotinamide-methylpherase reaction is described by the following equation:
Regional-scale forest ecosystem modeling: database development, model predictions and validation using a Geographic Information System

Regional-scale forest ecosystem models can provide insight into how forest hydrology and productivity differ in response to variations in climate and soil conditions. However, the databases necessary to define and validate these models are difficult to compile and utilize. The use of a Geographic Information System (GIS) can greatly simplify problems in database management. As an example of regional-scal e ecosystem model database development and model validation, the Arc-Info GIS and the PnET-IIS forest ecosystem model were used to predict and validate annual drainage and net primary productivity (NPP) on a 0.5° x 0.5° grid (approximately 50 x 75 km) for southern pine forests in the state of Georgia, USA. PnET-IIS is a lump-sum physiological model which used historic climate data from 1951 to 1984, along with soil water-holding capacity and species-specific vegetation charac- teristics. Annual predictions of drainage were well correlated with measured United States Geological Survey (USGS) drainage (r = 0.87, p < 0.0001), and predicted NPP was related with Forest Inventory Assessment (FIA) growth data collected across the state (r = 0.84, p < 0.0001). This study demonstrated the utility of a GIS in broad-scale ecosystem modeling and suggests that the need for model/GIS inter- facing in future research will continue to increase.
Robust and Fast Tracking via Joint Collaborative Representation

In this paper, we present a robust and fast tracking method based on joint collaborative representation. Traditional sparse coding based tracking methods code the candidates as a sparse linear combination of a series of object and trivial templates and perform time consuming L1 regularizations. In contrast to these methods, this paper adopts the L2-regularized least square models to reduce the computational complexity. The tracked object can be represented by the linear combination of a series of object templates, and also can be represented by candidate samples in the current frame. We propose a joint objective function to handle the tracking process. In addition, we introduce an effective update scheme to deal with the change of target appearance over time. Experiments on several challenging image sequences show that our proposed tracking method is robust and efficient.
Perishable Industries from the Windover Bog: An Unexpected Window into the Florida Archaic

Multi-disciplinary excavations at the Windover Bog site (8BR246) in 1986 and 1987 yielded a remarkably well-preserved but very fragile corpus of fiber-based and wood artifacts in direct association with a series of Early Middle Archaic burials. This suite of mid-sixth millennium B.C. materials includes not only the oldest textiles from the American Southeast but also sophisticated basketry, cordage, and wood items previously undocumented (and unanticipated! ) at this time horizon in this part of Florida. The textile assemblage includes close-simple and close-diagonal twining, both with S-Twist wefts (paired and trebled); open twining with paired, Z-Twist wefts; and balanced plain weave. Significantly, many of these items are in the form of non-heddle loom-woven cloth. Represented forms include circular or globular bags, hoods, blankets, clothing, and what may be intentionally produced burial shrouds. Also observed are twisted and braided cordage, composite fiber, and fiber and wood construction. The wood assemblage includes a wide array of forms from minimally modified burial “stakes” to complex, extensively worked, “dumbbell“-style mullers. The Windover fiber and wood assemblage is summarized and compared to others in North and South America and the myriad roles of perishable industries are discussed in terms of the lives and deaths of their makers.
On‐line monitoring of hybridoma cell growth using a laser turbidity sensor

A high‐sensitivity turbidity probe was used for on‐line monitoring of the cell concentration in batch hybridoma cultivation. Good correlation between off‐line cell counts and the linearized sensor signal was found. The quality of the signal was sufficiently high to provide for on‐line estimation of the specific growth rate using an efficient filtering procedure. These positive results suggest that such laser turbidity sensors will facilitate development of systems for on‐line monitoring and control of animal cell cultivations. © 1992 John Wiley & Sons, Inc.
ROOT HAIR DEFECTIVE3 Family of Dynamin-Like GTPases Mediates Homotypic Endoplasmic Reticulum Fusion and Is Essential for Arabidopsis Development1[W][OPEN]

RHD3 proteins mediate ER fusion and are essential for plant development and the formation of the tubular ER network. In all eukaryotic cells, the endoplasmic reticulum (ER) forms a tubular network whose generation requires the fusion of ER membranes. In Arabidopsis (Arabidopsis thaliana), the membrane-bound GTPase ROOT HAIR DEFECTIVE3 (RHD3) is a potential candidate to mediate ER fusion. In addition, Arabidopsis has two tissue-specific isoforms of RHD3, namely RHD3-like (RL) proteins, and their function is not clear. Here, we show that a null allele of RHD3, rhd3-8, causes growth defects and shortened root hairs. A point mutant, rhd3-1, exhibits a more severe growth phenotype than the null mutant, likely because it exerts a dominant-negative effect on the RL proteins. Genetic analysis reveals that the double deletion of RHD3 and RL1 is lethal and that the rhd3 rl2 plants produce no viable pollen, suggesting that the RL proteins are redundant to RHD3. RHD3 family proteins can replace Sey1p, the homolog of RHD3 in yeast (Saccharomyces cerevisiae), in the maintenance of ER morphology, and they are able to fuse membranes both in vivo and in vitro. Our results suggest that RHD3 proteins mediate ER fusion and are essential for plant development and that the formation of the tubular ER network is of general physiological significance.
THE HITTITE SEAPORT IZZIYA at Late Bronze Age Kinet Höyük (Cilicia)

Recent excavations at Kinet Höyük, an ancient Cilician seaport in the northeastern Mediterranean, document the cultural transformations that were exerted by the Late Bronze Age Hittite state to secure its peripheral territories. During the Middle Bronze Age, Kinet Höyük had maintained its regional identity while prospering from the maritime commercial network that flourished along the Levantine coast. This regional profile changed when Kinet Höyük and its Cilician neighbors came under Hittite pressure ca. 1500 b.c.e. , and adopted the material culture of central Anatolia. As the Hittite seaport Izziya, Kinet Höyük shows that the Anatolianizing process was sudden, effective, and enduring.
Wideband microstrip ring resonator bandpass filter with asymmetrically-loaded stubs

In this work, a multiple-resonance microstrip ring resonator with asymmetrically-loaded stubs has been proposed and investigated. Based on transmission line theory, a single multiple-resonance ring resonator with asymmetrically-loaded stubs is analyzed. Two extra transmission zeros have been observed and utilized to improve the stopband performance. Simulated results are well confirmed by the measurement and show the widened and deepened upper stopband, as well as a sharpened cut-off skirt.
Uniform clustered particle filtering for robot localization

Localization is a fundamental ability for an autonomous mobile robot. Different particle filter based solutions to the problem are simulated in a software simulator, and the results are compared and discussed. The weighted bootstrap alter, clustering particle alter, and the uniform particle alter are examined. A new method based on the clustered particle alter and the uniform particle alter the uniform clustering particle alter, is also proposed and evaluated.
Analysis of Drugs Illegally Added into Chinese Traditional Patent Medicine Using Surface-enhanced Raman Scattering

Illegal chemicals, which could cause unpredictable side effects, may be added into traditional Chinese medicine (TCM) for a rapid healing effect. In this report, a surface-enhanced Raman scattering (SERS) analysis method for five kinds of illegally added drugs (rosiglitazone maleate, phenformin hydrochloride, metformin hydrochloride, pioglitazone hydrochloride and sibutramine hydrochloride) in Chinese traditional patent medicine (CTPM) has been demonstrated, including simultaneous detections of drug mixtures with CTPM. Silver colloidal, prepared by a sodium citrate reaction, was used as a SERS substrate. The optimum pH condition for each drug has also been explored because of its combined effect on protonation, surface charge, repulsion of an analyte and nanoparticles. Furthermore, the simultaneous detection of two or three kinds of these chemicals has been carried out. Characteristic peaks are employed for qualitative analysis. This is the first research using SERS for the analysis of drug mixtures in CTPM without any separation process.
Distorted colloidal arrays as designed template

In this paper, a novel type of colloidal template with broken symmetry was generated using commercial, inductively coupled plasma reactive ion etching (ICP-RIE). With proper but simple treatment, the traditional symmetric non-close-packed colloidal template evolves into an elliptical profile with high uniformity. This unique feature can add flexibility to colloidal lithography and/or other lithography techniques using colloidal particles as building blocks to fabricate nano-/micro-structures with broken symmetry. Beyond that the novel colloidal template we developed possesses on-site tunability, i.e. the transformability from a symmetric into an asymmetric template. Sandwich-type particles with eccentric features were fabricated utilizing this tunable template. This distinguishing feature will provide the possibility to fabricate structures with unique asymmetric features using one set of colloidal template, providing flexibility and broad tunability to enable nano-/micro-structure fabrication with colloidal templates.
Enterocytic CYP3A4 in a paediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis.

AIMS To investigate the effects of age and disease states on the expression and activity of intestinal CYP3A4 in a paediatric population. METHODS Duodenal biopsies and surgical sections were collected from 104 paediatric patients (age range 2 weeks to 17 years) and from 11 foetuses. An S9 fraction was prepared in each case. CYP3A4 expression was assessed by Western blotting and by immunohistochemistry; activity was measured by the rate of formation of 6beta-hydroxytestosterone from testosterone. Villin expression was used as a marker of enterocyte harvest to normalize CYP3A4 expression and activity data. RESULTS In the 74 histologically normal paediatric biopsies there were statistically significant increases in CYP3A4 expression (r2 = 0.19, P = 0.001) and activity (r2 = 0.17, P = 0.02) with age. CYP3A4 was practically absent in fetal duodenum and was expressed at relatively low levels in neonates (P < 0.05 between neonates and children > 5 years). Active coeliac disease resulted in significant (P < 0.001) decreases in CYP3A4 expression and activity. CONCLUSIONS Duodenal CYP3A4 is present at significantly lower levels in neonates and in patients with active coeliac disease. This may have clinical significance with respect to the oral bioavailability of CYP3A4 substrates.
Development and validation of the neck dissection impairment index: a quality of life measure.

OBJECTIVES To validate a health-related quality-of-life (QOL) instrument for patients following neck dissection and to identify the factors that affect QOL following neck dissection. DESIGN Cross-sectional validation study. SETTING The outpatient clinic of a tertiary care cancer center. PATIENTS Convenience sample of 54 patients previously treated for head and neck cancer who underwent a selective neck dissection or modified radical neck dissection (64 total neck dissections). Patients had a minimum postoperative convalescence of 11 months. Thirty-two underwent accessory nerve-sparing modified radical neck dissection, and 32 underwent selective neck dissection. MAIN OUTCOME MEASURE A 10-item, self-report instrument, the Neck Dissection Impairment Index (NDII), was developed and validated. Reliability was evaluated with test-retest correlation and internal consistency using the Cronbach alpha coefficient. Convergent validity was assessed using the 36-Item Short-Form Health Survey (SF-36) and the Constant Shoulder Scale, a shoulder function test. Multiple variable regression was used to determine variables that most affected QOL following neck dissection RESULTS The 10-item NDII test-retest correlation was 0.91 (P<.001) with an internal consistency Cronbach alpha coefficient of.95. The NDII correlated with the Constant Shoulder Scale (r = 0.85, P<.001) and with the SF-36 physical functioning (r = 0.50, P<.001) and role-physical functioning (r = 0.60, P<.001) domains. Using multiple variable regression, the variables that contributed most to QOL score were patient's age and weight, radiation treatment, and neck dissection type. CONCLUSIONS The NDII is a valid, reliable instrument for assessing neck dissection impairment. Patient's age, weight, radiation treatment, and neck dissection type were important factors that affect QOL following neck dissection.
CMOS compatible acoustic particle velocity sensors

In this work we propose 2D acoustical particle velocity (APV) sensors produced by post processing silicon chips designed with the STMicroelectronics 0.32 µm BCD6s process. The sensors consist of two conductive wires suspended on dielectric membranes, separated by a 10 µm air gap. Heat exchange between the wires, heated by an electrical current, is modulated by the local velocity of the medium, producing temperature oscillations, which are transformed into voltage oscillations by the wire temperature coefficient of resistance (TCR). Experimental characterization of the sensors, based on the standing wave tube method, is presented.
Fine Pitch Compliant Bump Interconnection for Flip chip on Flexible Display Packaging by Anisotropic Conductive Film

Today, there is an increasing demand for flexible liquid crystal display (LCD) in many applications such as mobile phone, smart cards, electronic newspaper and integrated display. The requirement for better display resolution and image quality necessitate the use of advanced packaging technology because of higher number of inputs/outputs to be interconnected. Flip chip technology can meet some key points of the demand. However, due to the temperature limitation of substrate material and manufacture process, the traditional flip chip technology are not feasible at all to be used in packaging of flexible display and smart card even though low cost, high density and high reliability are the advantages of flip chip process. To establish fine pitch driver IC packaging process with low temperature for flexible display and smart card, flip chip on high Tg plastic substrate with anisotropic conductive fdm (ACF) was studied in this paper. Bonding temperature was designed by thermal analysis such as DSC and peeling strength. Bonding pressure was also defined by relationship between contact resistance and applied loading. In addition, novel bump with compliant buffer layer was investigated for the thermo-compression process. Interestingly, lower contact resistance interface was obtained by using compliant bump bonding than traditional Au bump bonding due to the compliancy of the bump structure. Cross-section view from SEM was also studied to show the deformation relationship of conductive particles, plastic substrate and bump. Finally, the reliability tests of, 85degC /85% RH thermal humidity storage test (THST), and -40degC ~125degC thermal cycling test (TCT) were carried out for evaluating electrical properties. Increasing contact resistance after environment tests were mainly due to the loss of contact by thermal stress effect and moisture absorption by epoxy.
A digital CMOS fully connected neural network with in-circuit learning capability and automatic identification of spurious attractors

Describes a completely connected feedback network with 64 binary neurons, using digital CMOS technology. The architecture implements a linear systolic loop, in which each neuron stores locally its own synaptic coefficients, and the potential calculation needs N time steps, each performing N partial weighted sums, to realize the N/sup 2/ operations needed. It implements internal learning capabilities, using the Widrow-Hoff rule, which converges towards the pseudo-inverse rule by iteration, thus allowing partial correlation between prototypes, and a higher capacity, compared to the Hebb rule. Also, it implements an internal mechanism for detecting relaxations on spurious states. The average retrieval speed is about 20 mu s, whereas the learning time is approximately 15 to 30 ms for 15 moderately correlated prototypes. <<ETX>>
Is the Iot a tech bubble for cities?: With more cities joining the smart city revolution and investing in sensors and other iot devices, the risk of a new tech bubble is rising

During the last Mobile World Congress-the biggest technology conference in the world-the Internet of Things (IoT) was one of the most talked about topics, neck and neck with wireless networks and spectrum. IoT technologies can help cities to manage their resources better, monitor smart grids, deploy services as needed, and respond to emergencies in a more timely and efficient manner. With more cities joining the smart city revolution and investing in sensors and other IoT devices, the risk of a new tech bubble is rising.
The effects of midazolam and etomidate on the antioxidant system in the rat liver

This study was conducted to investigate the histopathological and biochemical effects of midazolam and etomidate, which are intravenous anesthetics used in surgical operations, on rat liver. There were 3 study groups each consisting of 9 animals: the control, midazolam, and etomidate groups. Midazolam and etomidate were administered 10 times with 1-day intervals. At the end of the study, tissues were taken for histological examination and biochemical analysis. We determined superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) levels in the liver. There was a slight increase in MDA level in the midazolam-exposed group when compared with the controls, and this was not statistically significant. However, SOD and CAT activities were significantly increased in the midazolam group. We found slight damage in histological sections in parallel to biological findings. MDA levels were significantly increased in the etomidate group and SOD and CAT activities were also prominent in this group. More histological changes like hepatocyte degeneration, vascular congestion, and mononuclear cell infiltration were observed in the etomidate group and this was statistically significant. We can say that these intravenous anesthetic agents may cause dose-dependent damage in tissue. Therefore, we think that one must be cautious of the administration duration and dose levels of anesthetics during surgical operations.
Phase shift mask etch process development utilizing a scatterometry-based metrology tool

Phase, along with defect levels and CD, must be closely monitored on 45nm technology node masks. The final phase shift of a mask is highly dependent on the ability of the etch tool to stop at precisely the correct depth. Developing etch processes and endpoint recipes for successful phase shift processing depends on rapid and accurate measurement of etch depth. In many mask shops, these measurements are made by either direct phase measurement tools or atomic force microscopes (AFM). These tools have relatively low throughput. In the case of the direct phase measurement tool, the large measurement spot size precludes the measurement of the small features most interesting to mask makers. A need exists for a relatively fast measurement tool that can be applied to features <1μm in size. As part of Oerlikon USA's continuous etch process improvement efforts, the etch depth measurement capabilities of a scatterometry based metrology tool were explored. Phase shift masks (one EAPSM, one AAPSM) were created to act as standards for our experiments. Regions of each mask were etched to various depths using an Oerlikon Mask Etcher system, and then measured with both a commercial AFM and an n&k Technology 1700-RT scatterometry tool. Using this data, recipes capable of measuring quartz trench features, partially-etched MoSi trench features, and bulk MoSi films were developed on the n&k 1700-RT. Phase uniformity data taken from actual etch experiments will be provided, as well as data showing the repeatability of each system, and a comparison of the relative measurement times.
Renin-angiotensin system-regulating aminopeptidases in tumor growth of rat C6 gliomas implanted at the subcutaneous region.

BACKGROUND Angiotensin peptides play roles in brain tumor infiltration and associated angiogenesis. MATERIALS AND METHODS We explored the roles of soluble and membrane-bound forms of renin-angiotensin system-regulating aminopeptidase N (APN)-, aminopeptidase B (APB)-, glutamate aminopeptidase- and aspartate aminopeptidase (AspAP)-specific activities on tumor growth in the rat C6 glioma model with implantation into the subcutaneous abdomen of Wistar rats, evaluating these activities as biological markers. The tumor volume was assessed for three weeks and a sample of tumor was obtained every seven days to obtain the soluble and membrane-bound fraction, in order to assay enzyme activities fluorometrically using their corresponding aminoacyl-β-naphthylamide as substrates. RESULTS We found a time-dependent decrease in soluble and membrane-bound APN and APB. Soluble AspAP increases with tumor growth in a time-dependent manner. CONCLUSION Although gliomas are heterogeneous tissues, angiotensin peptides are involved in this model of tumor growth and their role could be analyzed through their corresponding regulatory proteolytic enzymes.