Miracle-dz/UniFAR-FTUs huggingface dataset:
Consensus clustering approach to group brain connectivity matrices

A novel approach rooted on the notion of consensus clustering, a strategy developed for community detection in complex networks, is proposed to cope with the heterogeneity that characterizes connectivity matrices in health and disease. The method can be summarized as follows: (a) define, for each node, a distance matrix for the set of subjects by comparing the connectivity pattern of that node in all pairs of subjects; (b) cluster the distance matrix for each node; (c) build the consensus network from the corresponding partitions; and (d) extract groups of subjects by finding the communities of the consensus network thus obtained. Different from the previous implementations of consensus clustering, we thus propose to use the consensus strategy to combine the information arising from the connectivity patterns of each node. The proposed approach may be seen either as an exploratory technique or as an unsupervised pretraining step to help the subsequent construction of a supervised classifier. Applications on a toy model and two real datasets show the effectiveness of the proposed methodology, which represents heterogeneity of a set of subjects in terms of a weighted network, the consensus matrix.
No Wrong Door: Can Clinical Care Facilitate Veteran Engagement in Housing Services?

It is well established that providing stable housing to homeless persons improves health outcomes. It is less clear whether engagement in clinical care facilitates housing outcomes. We present a post hoc analysis of a prospective, community-based randomized controlled trial of homeless veterans not actively receiving or assigned to a primary care. Study subjects were interviewed at baseline, 1 month and 6 months and survey results were supplemented/verified by review of all notes in their VA electronic medical record for 6 months postenrollment. A total of 142 subjects with complete data were included in this analysis: 82 (57.7%) were in a stable sheltering/housing arrangement (transitional housing, stably doubled-up, independent housing) at baseline and stayed stable; 36 (25.4%) started in an unstable sheltering arrangement (unsheltered, emergency sheltered, unstable doubled-up arrangement) and moved into stable sheltering/housing while 24 (17.0%) individuals either started in and stayed unstably sheltered or went from a stable to an unstable arrangement. Of 36 individuals who transitioned from unstable to stable sheltering/housing, 25 (69.4%) accessed primary care within 1 month compared with 37.5% of the persistently unstable sheltering group and 57.3% of the stably sheltered/housed group (p = .05). Of those with care within 1 month, their average time from unstable to stable housing was 84.8 days compared with 165.9 days for those who do not access care (p = .02). Of those receiving primary care within 1 month of enrollment, 88.9% were in stable sheltering at 6 months. These findings suggest an important role for clinical engagement in helping achieve housing stability for homeless veterans.
miRNA Long-Term Response to Early Metabolic Environmental Challenge in Hypothalamic Arcuate Nucleus

Epidemiological reports and studies using rodent models indicate that early exposure to nutrient and/or hormonal challenges can reprogram metabolism at adulthood. Hypothalamic arcuate nucleus (ARC) integrates peripheral and central signals to adequately regulate energy homeostasis. microRNAs (miRNAs) participate in the control of gene expression of large regulatory networks including many signaling pathways involved in epigenetics regulations. Here, we have characterized and compared the miRNA population of ARC of adult male rats continuously exposed to a balanced metabolic environment to the one of adult male rats exposed to an unbalanced high-fat/high-carbohydrate/moderate-protein metabolic environment during the perinatal period and/or at adulthood that consequently displayed hyperinsulinemia and/or hyperleptinemia. We identified more than 400 miRNA species in ARC of adult male rats. By comparing the miRNA content of six biological replicates in each of the four perinatal/adult environments/rat groups, we identified the 10 miRNAs specified by clusters miR-96/182/183, miR-141/200c, and miR-200a/200b/429 as miRNAs of systematic and uncommonly high variation of expression. This uncommon variation of expression may underlie high individual differences in aging disease susceptibilities. By comparing the miRNA content of the adult ARC between the rat groups, we showed that the miRNA population was not affected by the unbalanced adult environment while, in contrast, the expression of 11 miRNAs was repeatedly impacted by the perinatal unbalanced environment. Our data revealed a miRNA response of adult ARC to early metabolic environmental challenge.
Effect of varying cashew dust and resin on friction material formulation: stability and sensitivity of μ to pressure, speed and temperature

Inconsistent friction level during braking at different speed and pressure is a major concern to the brake pad/lining manufacturers as it is proven to be a formulation dependent. The behaviour of friction of an NAO brake pad is highly complex under a set of dynamically variable pressure speed and temperatures. This paper examines the sensitivity of friction (μ) towards braking pressure and sliding speed. Normally, the organic components burn off at elevated temperature, reducing the brake effectiveness and hence its temperature sensitivity is also carried out by fade test. This paper discusses the effect of organic components, namely resin and the cashew friction dust in a disc brake pad formulation. Three pads with varying resin (10.11, 11.11, 12.11 percentage by weight) and the cashew dust (9.33, 10.33, 11.33 percentage by weight) are fabricated and their effect in relation to stability of friction is studied by carrying out the test on the inertia dynamometer following JASO C 406 schedule. Optimisation of the ingredients is carried out using the response surface methodology. It is observed that composites with 10.11% resin and 9.33% cashew dust resulted in better performance with consistent friction level viz. least sensitivity of μ to operating variables, namely speed and pressure by carrying out a regression analysis.
Effect of hydration on the mechanical properties of anion exchange membranes

Abstract : Anion exchange membranes (AEM) are promising solid polymer electrolytes for use in alkali fuel cells and electrochemical conversion devices. The dynamic nature of the fuel cell environment requires that AEMs operate at a range of hydration levels. Water sorption is critical for ion conduction, but excess water uptake causes dimensional swelling and mechanical instability. Ion conduction is slower in AEMs, compared to proton exchange membranes (PEM), making it important to minimize overall transport resistance by reducing membrane thickness; however, maintaining mechanical durability is difficult as thickness is reduced. Achieving an AEM with high conductivity and good mechanical durability is a difficult balance, which was the focus of this thesis. Various polymer chemistries were investigated with respect to ion conduction, morphology, swelling, and mechanical properties as potential AEMs. The success of perfluorosulfonic acid PEMs inspired synthesis of perfluorinated AEMs, but cation functionalization was low, and proved chemically unstable, resulting in poor performance. Random polyiosoprene copolymers with high ion concentration were solution processed into films and subsequently crosslinked to generate solid AEMs. Diblock copolymers were studied due to their ability to phase separate into organized morphologies for efficient ion transport, but polymer chemistry greatly influenced mechanical performance. A polystyrene based diblock resulted in stiff, brittle AEMs with insufficient strength, but a polyethylene based diblock AEM produced large, flexible films.
Current Procedural Terminology Coding for Surgical Pathology: A Review and One Academic Center's Experience With Pathologist-Verified Coding.

CONTEXT. — The Current Procedural Terminology (CPT) system is a standardized numerical coding system for reporting medical procedures and services, and is the basis for reimbursement of health care providers by Medicare and other third-party payers. Accurate CPT coding is therefore crucial for appropriate compensation as well as for compliance with Medicare policies, and erroneous coding may result in loss of revenues and/or significant monetary penalties for a hospital or practice. OBJECTIVE. — To provide a review of the history, current state, and basic principles of CPT coding, in particular as it applies to the practice of surgical pathology, and to present our experience with initiating a new system of pathologist involvement in the review and verification of CPT codes, including the most common codes that require modification in our practice at the time of sign-out or post-sign-out auditing. DATA SOURCES. — Review of English language literature, published CPT resources from the American Medical Association and other professional organizations, and billing quality data from a single institution. CONCLUSIONS. — Although the appropriate extent of physician involvement in CPT coding is a matter of some debate, a multidisciplinary approach involving both health care providers and professional coders appears to be the best way to achieve accuracy.
Physico-Chemical Characterisation of the Influence of Moisture on the Fibre/Matrix Interaction in Epoxy/Anhydride Composites

Abstract The effect of moisture on the fibre/matrix interaction in epoxy/anhydride composites is investigated and explained through the characterisation of the matrix cure in the interphase. The fibre/matrix interaction is inferred from ILSS measurements on the composite, which are compared with a recently-introduced DSC interaction parameter. The matrix cure in the bulk as well as in the interphase is characterised through FT-IR microspectroscopy. Complementary information is gained by measuring the overall Tg value. Moisture is shown to lower the fibre/matrix interaction if the prepreg (= composite precursor) is stored at room temperature or lower prior to final cure. This is due to the reduced crosslink density of the matrix. For PE prepreg stored in ordinary atmospheric conditions, moisture from the surroundings lowers the fibre/matrix interaction sharply. If the prepreg is stored in a dry environment, nearly no effect of the storage is detected on the fibre matrix interaction in PE (polyethylene) fib.
Spotsizer: High-throughput quantitative analysis of microbial growth.

Microbial colony growth can serve as a useful readout in assays for studying complex genetic interactions or the effects of chemical compounds. Although computational tools for acquiring quantitative measurements of microbial colonies have been developed, their utility can be compromised by inflexible input image requirements, non-trivial installation procedures, or complicated operation. Here, we present the Spotsizer software tool for automated colony size measurements in images of robotically arrayed microbial colonies. Spotsizer features a convenient graphical user interface (GUI), has both single-image and batch-processing capabilities, and works with multiple input image formats and different colony grid types. We demonstrate how Spotsizer can be used for high-throughput quantitative analysis of fission yeast growth. The user-friendly Spotsizer tool provides rapid, accurate, and robust quantitative analyses of microbial growth in a high-throughput format. Spotsizer is freely available at https://data.csiro. au/dap/landingpage? pid=csiro:15330 under a proprietary CSIRO license.
Eye and Mouse Coordination During Task: From Behaviour to Prediction

The study of web users’ behaviour is of crucial importance for understanding people reaction when browsing websites. Eye-tracking is a precise tool for this purpose, but it is hard to scale up when trying to apply it to a wide range of situations and websites. On the other hand, mouse-tracking fulfills these requirements. Unfortunately, mouse data provides a limited approximation of the eye position as it was shown in the literature. In this paper, we investigated the relationship between mouse and eye behaviour on several kind of websites with three different tasks to create models based on these behaviours. Our findings were that 1) saliency Pearson’s correlation is not suitable to analyse eye and mouse coordination, 2) this coordination is altered according to the task, 3) scroll speed directly influence where the eyes are during the scroll, 4) amplitude vary according to eyes position before the scroll and 5) by using the X axis variations it is possible to find the moments where it is easier to model eyes location from mouse location.
Socioeconomic inequalities in child vaccination in low/middle-income countries: what accounts for the differences?

Background Socioeconomic inequalities in child vaccination continue to be a global public health concern. This study aimed to measure and identify factors associated with socioeconomic inequalities in full immunisation coverage against the four core vaccine-preventable diseases (ie, bacille Calmette-Guérin, diphtheria-tetanus-pertussis (three doses), polio (three doses) and measles vaccines) in 46 low/middle-income countries. Methods The most recent nationally representative samples of children (aged 10–59 months, n=372 499) collected through the Demographic Health Surveys were used to measure vaccination rates. The concentration index (C) was used to quantify socioeconomic inequalities in vaccination coverage. Furthermore, meta-regression analyses were used to determine factors affecting socioeconomic inequalities in vaccination coverage across countries. Results Results suggested that immunisation coverage was pro-rich in most countries (median C=0.161, IQR 0.131). Gambia (C=−0.146, 95% CI −0.223 to −0.069), Namibia (C=−0.093, 95% CI −0.145 to −0.041) and Kyrgyz Republic (C=−0.227, 95% CI −0.304 to −0.15) were the only countries where children who belong to higher socioeconomic status group were less likely to receive all the four core vaccines than their lower socioeconomic status counterparts. Meta-regression analyses suggested that, across countries, the concentration of antenatal care visits among wealthier mothers was positively associated with the concentration of vaccination coverage among wealthier children (coefficient=0.606, 95% CI 0.301 to 0.911). Conclusions Pro-rich distribution of child vaccination in most low/middle-income countries remains an important public health policy concern. Policies aimed to improve antenatal care visits among mothers in lower socioeconomic groups may mitigate socioeconomic inequalities in vaccination coverage in low/middle-income countries.
Creep rupture behaviour of circumferentially welded mod. 9Cr–1Mo steel pipe subject to internal pressure and axial load

The multi-axial creep strength of circumferential welds in power piping, including failure mode and failure life against a wide range of stress ratios and stress levels, was newly examined in this paper. The creep rupture behaviour of modified 9Cr–1Mo steel (9Cr–1Mo–VNb steel; ASME P91) pipe with a circumferential weld subject to combined internal pressure and axial load was experimentally investigated at 650 °C. The test results, with several kinds of stress ratios of macroscopic axial and hoop stress can be summarised as follows. Along with the increased stress ratio (axial/hoop), both failure location and failure mode changed from a base metal failure caused by hoop stress to an FGHAZ (fine-grained heat affected zone) failure due to axial stress. The stress ratio where the failure mode changed was ‘0.8’. Strength reduction in FGHAZ failure by axial stress should be considered in the structural design of circumferential welds. A series of FEM creep analysis was carried out to discuss the relation of the failure mode to both the local stress distribution and the damage. The failure mode variation along with the increase in the stress ratio is also discussed based on simplified ductile creep failure analysis.
Multi-annulus partition based image representation for image classification

The paper proposes a new spatial extension of Bag-of-Features BoF formalism for classification tasks. The scheme is based on multi-annulus partition which contains much spatial information of image space. Experiments are conducted using final super-vector image representation in Support Vector Machine SVM framework for classification on Oxford flowers and 15 scenes data sets. The results of experiment have shown the effectiveness of our scheme in terms of multiple performance metrics. In addition, our scheme is conceptually simple and easily adoptable. It can lead to much more compact representations and more invariance to image transformation compared to several existing works.
Turkish Migrant Women with Recurrent Depression: Results from Community-based Self-help Groups

ABSTRACT The study focuses on psychosocial functioning of female Turkish immigrants in Austria with recurrent depressive disorder participating in self-help groups. Self-help groups guided by group leaders of Turkish descent should increase autonomy in participants, providing the opportunity to follow their ethnic health beliefs. Turkish immigrant women (n = 43) with recurrent depressive disorder participated in self-help groups over four months. Qualitative data of participants and group leaders, containing interviews, group protocols and supervision protocols of group leaders were analyzed using the qualitative content analysis for effects on psychosocial function, such as interaction with others, illness beliefs and benefit from self-help group. Women reported feelings of being neglected and violated by their husbands. They stated that they had gained strength and had emancipated themselves from their husbands. Self-help groups functioned as social resources and support for changes in participants' lives. Further interventions should integrate the functional value of depressive symptoms and focus on social support systems and social networks.
Implementing Resistance Training in Secondary Schools: A Cluster Randomized Controlled Trial

Purpose Guidelines recommend that young people engage in muscle-strengthening activities on at least 3 d·wk−1. The purpose of this study was to examine the effect of a school-based intervention focused on resistance training (RT) for adolescents. Methods The “Resistance Training for Teens” intervention was evaluated using a cluster-randomized, controlled trial with 607 adolescents (50.1% girls; 14.1 ± 0.5 yr) from 16 secondary schools. Teachers were trained to deliver the intervention, which included the following: (i) an interactive student seminar; (ii) a structured physical activity program, focused on RT; (iii) lunchtime fitness sessions; and (iv) Web-based smartphone apps. The primary outcome was muscular fitness (MF) and secondary outcomes included body mass index, RT skill competency, flexibility, physical activity, self-efficacy, and motivation. Assessments were conducted at baseline, 6 months (postprogram; primary end point), and 12 months (follow-up). Outcomes were assessed using linear mixed models, with three potential moderators tested using interaction terms (and subgroup analyses where appropriate). Results For the primary outcome (MF), a group–time effect was observed at 6 months for the upper body (2.0 repetitions; 95% confidence interval (CI), 0.8–3.2), but not the lower body (−1.4 cm; 95% CI, −4.7–1.9). At 6 months, there were intervention effects for RT skill competency and self-efficacy, but no other secondary outcomes. Effects for upper body MF and RT skill competency were sustained at 12 months. Despite overall no effect for body mass index, there was a group–time effect at 12 months among students who were overweight/obese at baseline (−0.55 kg·m−2; 95% CI, −1.01 to −0.08). Conclusions The school-based RT intervention resulted in immediate and sustained improvements in upper body MF and RT skill competency, demonstrating an effective and scalable approach to delivering RT within secondary schools.
Lowering Endogenous Cathepsin D Abundance Results in Reactive Oxygen Species Accumulation and Cell Senescence*

Cathepsin D is reportedly to be closely associated with tumor development, migration, and invasion, but its pathological mechanism is not fully elucidated. We aimed to evaluate phenotypic changes and molecular events in response to cathepsin D knockdown. Lowering endogenous cathepsin D abundance (CR) induced senescence in HeLa cells, leading to reduced rate of cell proliferation and impaired tumorigenesis in a mouse model. Quantitative proteomics revealed that compared with control cells (EV), the abundances of several typical lysosomal proteases were decreased in the lysosomal fraction in CR cells. We further showed that cathepsin D knockdown caused increased permeability of lysosomal membrane and reactive oxygen species accumulation in CR cells, and the scavenging of reactive oxygen species by antioxidant was able to rescue cell senescence. Despite the increased reactive oxygen species, the proteomic data suggested a global reduction of redox-related proteins in CR cells. Subsequent analysis indicated that the transcriptional activity of nuclear factor erythroid-related factor 2 (Nrf2), which regulates the expression of groups of antioxidant enzymes, was down-regulated by cathepsin D knockdown. Importantly, Nrf2 overexpression significantly reduced cell senescence. Although transient oxidative stress promoted the accumulation of Nrf2 in the nucleus, we showed that the Nrf2 protein exited nucleus if oxidative stress persisted. In addition, when cathepsin D was transiently knocked down, the cathepsin-related events followed a sequential order, including lysosomal leakage during the early stage, followed by oxidative stress augmentation, and ultimately Nrf2 down-regulation and senescence. Our results suggest the roles of cathepsin D in cancer cells in maintaining lysosomal integrity, redox balance, and Nrf2 activity, thus promoting tumorigenesis. The MS Data are available via ProteomeXchange with identifier PXD002844.
Interactive Roles of DNA Helicases and Translocases with the Single-Stranded DNA Binding Protein RPA in Nucleic Acid Metabolism

Helicases and translocases use the energy of nucleoside triphosphate binding and hydrolysis to unwind/resolve structured nucleic acids or move along a single-stranded or double-stranded polynucleotide chain, respectively. These molecular motors facilitate a variety of transactions including replication, DNA repair, recombination, and transcription. A key partner of eukaryotic DNA helicases/translocases is the single-stranded DNA binding protein Replication Protein A (RPA). Biochemical, genetic, and cell biological assays have demonstrated that RPA interacts with these human molecular motors physically and functionally, and their association is enriched in cells undergoing replication stress. The roles of DNA helicases/translocases are orchestrated with RPA in pathways of nucleic acid metabolism. RPA stimulates helicase-catalyzed DNA unwinding, enlists translocases to sites of action, and modulates their activities in DNA repair, fork remodeling, checkpoint activation, and telomere maintenance. The dynamic interplay between DNA helicases/translocases and RPA is just beginning to be understood at the molecular and cellular levels, and there is still much to be learned, which may inform potential therapeutic strategies.