Miracle-dz/UniFAR-FTUs huggingface dataset:
Information Gained From Linking SEER Cancer Registry Data to State-Level Hospital Discharge Abstracts

Objectives.Our goal was to link patients from the Iowa Surveillance, Epidemiology, and End Results (SEER) Registry to their respective inpatient discharge abstracts from an Iowa Health Care Cost and Utilization Project (HCUP)–formatted database and evaluate whether this linkage provides information related to cancer treatment variation. Methods.Computer algorithms linked patients from the Iowa SEER Registry to discharge abstracts using 5 variables consistently defined between the databases (hospital identification, date of birth, admission date, discharge date, and zip code). Abstracts were reviewed for validity, and links not passing face validity were excluded. Subjects.Our sample contained 7,296 patients with early-stage breast cancer (I, IIa, IIb) with surgery from the Iowa SEER Registry from 1989 through 1994 with contacts only with Iowa hospitals. Results.Inpatient discharges abstracts were linked to 86.4% of the patients in our sample. More than 96% of the linked discharges for Medicare patients had a corresponding Medicare claim. Over 45% of the linked patients were not covered by Medicare. Comorbidity indexes were comparable to other published sources. Significant differences in diagnosis, comorbidities, and treatment were found across third-party payers. Conclusions.This linkage provides a valuable source of comorbidity and insurance data and perhaps the only source of secondary clinical information for the uninsured. This linkage is best suited for cancers requiring inpatient stays for treatment and for those states where border crossing for treatment is low.
ON THE DISTRIBUTION OF ZEROS OF POLYNOMIALS

We prove a subtle “one-sided” improvement of a classical result of P. Erdős and P. Turán on the distribution of zeros of polynomials. The proof of this improvement is quite short and rather elementary. Nevertheless it allows us to obtain a beautiful recent result of V. Totik and P. Varjú as a simple corollary, and in a somewhat stronger form, without any use of a potential theoretic machinery. Namely, if the modulus of a monic polynomial P of degree n (with complex coefficients) on the unit circle of the complex plane is at most 1+o(1) uniformly, then the multiplicity of each zero of P on the unit circle is o(n). Our approach is based on the interesting observation that the Erdős–Turán Theorem improves itself. Résumé: Nous prouvons un raffinement délicat d’un résultat classique de P. Erdős et P. Turán sur la distribution des zéros de polynômes. Bien que notre preuve soit brève et plutôt élémentaire, elle nous permet d’obtenir comme corollaire et sans recourir à la théorie du potentiel, une amélioration d’un résultat récent et élégant de V. Totik et P. Varjú: si le module sur le cercle unité du plan complexe d’un polynôme P monique, de degré n et à coefficients complexes est uniformément au plus 1+o(1), alors la multiplicité de chaque zéro de P sur le cercle unité est o(n). Notre approche repose sur l’observation, à notre avis intéressante, que le théorème de Erdős-Turán puisse en quelque sorte s’auto-raffiner.
Design and Analysis of In-Network Computation Protocols With Compressive Sensing in Wireless Sensor Networks

Compressive sensing (CS) provides a new paradigm for correlated data processing and transmission over wireless sensor networks (WSNs). In this paper, we take a new look to investigate the performance of CS for data gathering from the perspective of in-network computation. We formulate the problem of computing random projections for CS in WSNs as in-network function computation in random geometric networks. We focus on the design and performance analysis of the protocols that are efficient in terms of computation complexity. We first propose an efficient tree-based computation protocol with an optimal refresh rate and characterize the scaling laws of energy and latency requirements, which show that it can reduce energy consumption and latency compared with the traditional approach. Then, we present a more efficient block computation protocol by considering the correlations of temporal measurements in function computation to improve the performance in terms of refresh rate and energy consumption. We also devise a gossip-based scheme to improve the robustness of function computation, which is able to distribute computation results to all the nodes throughout the network. We show that the proposed protocol can improve upon the existing gossip-based schemes in terms of energy consumption. Finally, simulation results are also presented to demonstrate the effectiveness of the proposed protocols.
Development and Productivity of Jatropha curcas Plants Treated With Growth Regulators

The objective of the present work was to evaluate the effect of plant growth regulators (PGR) on the vegetative development and productivity of Jatropha curcas plants. A field experiment was conducted at the Goiás State University, Brazil, using two-year-old J. curcas plants planted with spacing of 3 × 2 m, using foliar applications of two PGR—trinexapac-ethyl and prohexadione-Ca. A randomized block design was used with four treatments (trinexapac-ethyl at 1 ml plant-1—T1; prohexadione-Ca at 2 mg plant-1—T2; trinexapac-ethyl at 1 ml plant-1 plus prohexadione-Ca at 2 mg plant-1—T3; and Control—T4), five replications, and plots consisting of two plants. Two applications of a 300 ml plant-1 solution with the treatments were performed with a 30-day interval after the leaf emergence period (late September and October 2017). The trinexapac-ethyl and prohexadione-Ca plant growth regulators increased the grain yield of Jatropha curcas plants by increasing their vegetative growth, and number of inflorescences, and female and hermaphrodite flowers, but had no effect on the uniformity of fruit maturation. The treatment in which both plant growth regulators were used presented the best results, generating more vigorous and productive plants.
Stimulation of Cell Elongation by Tetraploidy in Hypocotyls of Dark-Grown Arabidopsis Seedlings

Plant size is largely determined by the size of individual cells. A number of studies showed a link between ploidy and cell size in land plants, but this link remains controversial. In this study, post-germination growth, which occurs entirely by cell elongation, was examined in diploid and autotetraploid hypocotyls of Arabidopsis thaliana (L.) Heynh. Final hypocotyl length was longer in tetraploid plants than in diploid plants, particularly when seedlings were grown in the dark. The longer hypocotyl in the tetraploid seedlings developed as a result of enhanced cell elongation rather than by an increase in cell number. DNA microarray analysis showed that genes involved in the transport of cuticle precursors were downregulated in a defined region of the tetraploid hypocotyl when compared to the diploid hypocotyl. Cuticle permeability, as assessed by toluidine-blue staining, and cuticular structure, as visualized by electron microscopy, were altered in tetraploid plants. Taken together, these data indicate that promotion of cell elongation is responsible for ploidy-dependent size determination in the Arabidopsis hypocotyl, and that this process is directly or indirectly related to cuticular function.
Mental Health Problems in Adolescence and the Interpretation of Unambiguous Threat

Aberrant threat perception has been linked to paranoia, anxiety and other mental health problems, and is widely considered to be a core, transdiagnostic feature of psychopathology. However, to date there has been only limited investigation of whether mental health problems are associated with a biased interpretation of stimuli that have explicit (as opposed to ambiguous) connotations of threat. In the present study, 41 adolescents diagnosed with a mental illness and 45 demographically matched controls were asked to provide danger ratings of stimuli normatively rated as being either low or high in potential threat. All participants were also asked to complete background measures of cognitive function, mental health and wellbeing. The results indicated that the two groups did not differ in their capacity to discriminate between low and high threat stimuli, nor did they differ in the absolute level of threat that they attributed to these stimuli. However, for the control group, the overall level of threat perceived in facial stimuli was correlated with two important indices of mental health (depression and anxiety). No associations emerged in the clinical group. These data are discussed in relation to their potential implications for the role of aberrant threat perception in transdiagnostic models of mental health.
Imbalance of Th17 to Th1 cells in Behçet's disease.

OBJECTIVES Behçet's disease (BD) is a helper T cell-mediated autoimmune disease characterised by recurrent orogenital ulcers, uveitis and skin lesions. The helper T cells are divided into Th1, Th2 and Th17 cells according to the pattern of cytokine secretion. Th1 and Th17 cells can contribute to the development of the disease with their respective proinflammatory cytokines, IFN-γ and IL-17. In this study, we investigated the relative role of Th17, Th1 and Th2 cells in BD. METHODS Peripheral blood mononuclear cells were isolated from 30 patients with BD, for whom the detailed clinical manifestations and medication history were investigated and recorded. Surface markers and intracellular levels of IL-17, IFN-γ and IL-4 in isolated CD4+ T cells were measured using flow-cytometry from these patients and from two control groups, 34 rheumatoid arthritis patients and 24 healthy blood donors to analyse the relationship of Th1, Th17 and Th2 cells in BD. RESULTS The ratio of Th17/Th1 cells was significantly increased in BD compared to healthy controls (0.16±0.09 vs. 0.10±0.04, p=0.012), while there was no difference in the ratios of Th1/Th2 or Th17/Th2 cells. Th17/Th1 ratio was elevated in BD patients with uveitis or folliculitis compared to those without it (0.21±0.10 vs. 0.13±0.06, p=0.045 for uveitis; 0.18±0.10 vs. 0.12±0.05, p=0.036 for folliculitis). CONCLUSIONS Our results confirm that TH17 cells are instrumental in Behçet's uveitis and folliculitis. Furthermore, our findings suggest that the role of Th17 cells should be interpreted in the context of their ratio to Th1 cells.
Materials and Methods cell culture , rna isolation , and DNase treatment

Background: In most measurements of gene expression, mRNA is first reverse-transcribed into cDNA. We studied the reverse transcription reaction and its consequences for quantitative measurements of gene expression. Methods: We used SYBR green I-based quantitative real-time PCR (QPCR) to measure the properties of reverse transcription reaction for the -tubulin, glyceraldehyde-3-phosphate dehydrogenase, Glut2, CaV1D, and insulin II genes, using random hexamers, oligo(dT), and gene-specific reverse transcription primers. Results: Experimental variation in reverse transcriptionQPCR (RT-QPCR) was mainly attributable to the reverse transcription step. Reverse transcription efficiency depended on priming strategy, and the dependence was different for the five genes studied. Reverse transcription yields also depended on total RNA concentration. Conclusions: RT-QPCR gene expression measurements are comparable only when the same priming strategy and reaction conditions are used in all experiments and the samples contain the same total amount of RNA. Experimental accuracy is improved by running samples in (at least) duplicate starting with the reverse transcription reaction. © 2004 American Association for Clinical Chemistry
Differential Label-free Quantitative Proteomic Analysis of Shewanella oneidensis Cultured under Aerobic and Suboxic Conditions by Accurate Mass and Time Tag Approach*S

We describe the application of LC-MS without the use of stable isotope labeling for differential quantitative proteomic analysis of whole cell lysates of Shewanella oneidensis MR-1 cultured under aerobic and suboxic conditions. LC-MS/MS was used to initially identify peptide sequences, and LC-FTICR was used to confirm these identifications as well as measure relative peptide abundances. 2343 peptides covering 668 proteins were identified with high confidence and quantified. Among these proteins, a subset of 56 changed significantly using statistical approaches such as statistical analysis of microarrays, whereas another subset of 56 that were annotated as performing housekeeping functions remained essentially unchanged in relative abundance. Numerous proteins involved in anaerobic energy metabolism exhibited up to a 10-fold increase in relative abundance when S. oneidensis was transitioned from aerobic to suboxic conditions.
Foot landing state estimation from point cloud at a landing place

A method that estimates a foot landing state at a designated landing place from a point cloud of an uneven surface or rough terrain is proposed. The method geometrically searches for the stable pose of the foot and outputs not only the position and orientation but also the shape of the support polygon of the stable foot. The experimental results using point clouds obtained by simulation and real sensing are evaluated. The proposed method can also perform an important role for uneven surface walking by using HRP-2 in a simulation.
Hybrid termination of metamaterial CRLH antennas

This paper introduces a new hybrid termination of composite right left handed antenna. The hybrid termination if formed by short circuit loading coupled to open loading through air gap capacitor. A novel antenna operates at 2.4 GHz and 5.2 GHz with antenna dimensions 21×30 mm2 (only 9% compared to conventional microstrip antenna). The proposed new termination has resulted in increasing the electrical length of the open circuit composite right left handed antenna by 20%. for the same physical dimensions. The proposed antenna theoretical concepts is explained. The antenna performance is validated by full wave simulation and experimental measurements.
Differential neutrophil gene expression in blood and milk during pre-implantation pregnancy in Karan Fries cattle

ABSTRACT The blood leucocytes, neutrophils being the first line of defense, detect the implanting embryo, which is semi-allogenic, and show changes in their gene expression. It is possible to diagnose cattle as non-pregnant around 21–24 days post insemination by progesterone (P4) assay. Concentration of progesterone level in the inseminated animals may not be an accurate method for early pregnancy diagnosis. Identification of suitable methods that allow pregnancy diagnosis around or before day 20 after artificial insemination (AI) will be of considerable value. The present study has been carried out to understand the differential gene expression of IFI16 (interferon-inducible protein 16), MX1 (Myxovirus resistance 1), OAS1 (2'-5'-Oligoadenylate Synthetase 1) and TNFα (tumor necrosis factor alpha) genes on 0, 4, 8, 12, 15, 18 and 21 days post AI, respectively, from Karan Fries cattle as a tool for early pregnancy diagnosis in neutrophil cells isolated from blood and milk. Statistical analysis between pregnant and non-pregnant animals in both blood and milk samples revealed that IFI16 gene was upregulated in the milk samples of pregnant animals on 8th day post-AI and found to be significantly different (P < 0.05) between pregnant and non-pregnant cattle and may be used as a biomarker for early pregnancy detection in cattle.
Administration of Ephedrine versus Norepinephrine for Management of Post-Spinal Hypotension during Lower Limb Orthopedic Surgery

Background: Neuraxial anaesthesia technique induce vasodilation, this may result in hypotension requiring the administration of vasopressors drugs. The present study was conducted to compare the effects of intermittent I.V. boluses of ephedrine (EPH) and norepinephrine (NE) on maintain arterial blood pressure in patients undergoing lower limb orthopedic surgery during spinal. Aim: To compare the efficacy and safety of intermittent boluses administration of ephedrine (EPH) versus norepinephrine (NE) for treatment of hypotension patients during spinal anesthesia for patients undergoing lower limb orthopedic surgery. Patients and methods: A randomized, double-blinded study was carried out on 100 patients ASA I or II undergoing lower limb orthopedic surgery. The patients were divided into two groups of 50 patients, the ephedrine group (EPH group): received 5 mg intravenously bolus (IV) and the norepinephrine group (NE group): received 5μg intravenously bolus (IV) when hypotension occurred (systolic blood pressure decrease by 20% or more from baseline). Systolic blood pressure (SBP), mean arterial blood pressure (MAP) and heart rate (HR) were recorded at baseline (before spinal anasethesia) and after initiation of spinal anaesthesia at 3, 6, 9, 12, 15 minutes then every 5mins were measured for 30 mins then every 15 minutes up to end of surgery. The number of boluses of vasopressors, incidence of bradycardia, tachycardia and hypertension episodes were recorded. Also incidence of side effects during surgery were recorded. Results: There was no significant difference in SBP and MAP between both groups in all times P<0.05 however, the rise in heart rates were significant higher in group EPH than group NA at 6, 9, 12 mins (p <0.001) but bradycardia was not significantly different between the two groups P<0.05. The number of boluses of vasopressors required to maintain systolic blood pressure were lower in NE group 29/ 45 patients (64.4%) than EPH group 24/ 45 patients (53.3%). The incidence of hypertension and bradycardia were not significantly different between the two groups however tachycardia were significantly higher (P < 0.01) in group EPH. There was no significant difference in side effects during surgery between both groups. Conclusions: Norepinephrine is potent drug can be used as an alternative vasopressor for maintainance of blood pressure during post-spinal hypotension.
Characterization of a Putative Ovarian Oncogene, Elongation Factor 1α, Isolated by Panning a Synthetic Phage Display Single-Chain Variable Fragment Library with Cultured Human Ovarian Cancer Cells

Purpose: In an effort to identify cell surface targets and single short-chain antibody (scFv) for ovarian cancer therapy, we used a phage display approach to isolate an antibody with high reactivity against ovarian cancer. Experimental Design: A phage scFv library was subjected to panning against human SK-OV-3 ovarian cancer cells. A clone with high reactivity was selected and tested in immunoperoxidase staining on a panel of normal tissues and ovarian carcinoma. Using immunoprecipitation, a differentially expressed band was analyzed by mass spectrometry. The antigen subclass was characterized with reverse transcription-PCR on cDNA library of normal tissues, and 91 ovarian cancer specimens, and correlated with clinicohistopathologic characteristics. Results: Ninety-six individual scFv clones were screened in ELISA following panning. scFv F7 revealed high reactivity with ovarian cancer cell lines and showed intense staining of 15 fresh ovarian cancer specimens and no staining of a panel of normal tissues. A 40-kDa protein was identified to be translation elongation factor 1α1 (EEF1A1; P < 0.05). The expression of EEF1A2, a highly homologous and functionally similar oncogene, was found to be restricted only to the normal tissues of the heart, brain, and skeletal muscle. Aberrant EEF1A2 mRNA expression was found in 21 of 91 (23%) of ovarian cancer specimens and significantly correlated with increased likelihood of recurrence (P = 0.021). Conclusions: scFv F7 may represent an ovarian cancer–specific antibody against translation EEF1A family of translational factors. We propose that EEF1A2 may be a useful target for therapy of human ovarian cancer.
Influence of growth hormone supplementation in patients with thin endometrium undergoing frozen embryo transfer

Objective: To evaluate the effect of recombinant human growth hormone (rhGH) supplementation during hormone-replacement therapy and frozen-thawed embryo transfer (FET) in patients with thin endometrium. Methods: A retrospective research was conducted on 225 patients, who underwent artificial cycle FET in Shanghai, China, between January 2016 and November 2017. Data from 245 FET cycles were analyzed, of which 184 cycles received rhGH (GH group) and 61 did not (control group). Results: Clinical pregnancy and implantation rates were significantly higher in the GH group than those in the control group (64.7% vs. 49.2%, P = 0.032; 44.8% vs. 32.8%, P = 0.019, respectively). After logistic regression analysis, rhGH was considered the only significant variable that influenced clinical pregnancy rate, increasing it by 1.89-fold. On the other hand, the presence of rhGH did not seem to affect the early pregnancy loss. Conclusions: Our results indicated that simultaneous addition of rhGH could improve clinical outcomes of FET in patients with thin endometrium, particularly in patients between 30 and 34 years of age.
Novel Systems Modeling Methodology in Comparative Microbial Metabolomics: Identifying Key Enzymes and Metabolites Implicated in Autism Spectrum Disorders

Autism spectrum disorders are a group of mental illnesses highly correlated with gastrointestinal dysfunction. Recent studies have shown that there may be one or more microbial “fingerprints” in terms of the composition characterizing individuals with autism, which could be used for diagnostic purposes. This paper proposes a computational approach whereby metagenomes characteristic of “healthy” and autistic individuals are artificially constructed via genomic information, analyzed for the enzymes coded within, and then these enzymes are compared in detail. This is a text mining application. A custom-designed online application was built and used for the comparative metabolomics study and made publically available. Several of the enzyme-catalyzing reactions involved with the amino acid glutamate were curiously missing from the “autism” microbiome and were coded within almost every organism included in the “control” microbiome. Interestingly, there exists a leading hypothesis regarding autism and glutamate involving a neurological excitation/inhibition imbalance; but the association with this study is unclear. The results included data on the transsulfuration and transmethylation pathways, involved with oxidative stress, also of importance to autism. The results from this study are in alignment with leading hypotheses in the field, which is impressive, considering the purely in silico nature of this study. The present study provides new insight into the complex metabolic interactions underlying autism, and this novel methodology has potential to be useful for developing new hypotheses. However, limitations include sparse genome data availability and conflicting literature experimental data. We believe our software tool and methodology has potential for having great utility as data become more available, comprehensive and reliable.
Attribute Selection Using Information Gain and Naïve Bayes for Traffic Classification

This paper presents the value of good attributes in carrying out the package classification process Furthermore, attribute selection results can be of value in determining one type of data packet traffic. In obtaining the results (data) this study uses several stages of Data Capture, Feature Extraction and Feature Selection, but in this study only focuses on the process of feature selection using the gain and Entropy Information and Naïve Bayes algorithm. The testing process by dividing raw data into parts is 70 per cent for Training data and 30 per cent for testing data. The total data used is 6632, so for the training data obtained is 4642, while the data for testing is 1990. The results obtained are for the https data package type is 9 attributes, while for the HTTP data is 10 attributes. For further research can be added using another classification method as a comparison of data.