Miracle-dz/UniFAR-FTUs huggingface dataset:
Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin

Mechanisms for activating the actin-related protein 2/3 (Arp2/3) complex have been the focus of many recent studies. Here, we identify a novel mode of Arp2/3 complex regulation mediated by the highly conserved actin binding protein coronin. Yeast coronin (Crn1) physically associates with the Arp2/3 complex and inhibits WA- and Abp1-activated actin nucleation in vitro. The inhibition occurs specifically in the absence of preformed actin filaments, suggesting that Crn1 may restrict Arp2/3 complex activity to the sides of filaments. The inhibitory activity of Crn1 resides in its coiled coil domain. Localization of Crn1 to actin patches in vivo and association of Crn1 with the Arp2/3 complex also require its coiled coil domain. Genetic studies provide in vivo evidence for these interactions and activities. Overexpression of CRN1 causes growth arrest and redistribution of Arp2 and Crn1p into aberrant actin loops. These defects are suppressed by deletion of the Crn1 coiled coil domain and by arc35-26, an allele of the p35 subunit of the Arp2/3 complex. Further in vivo evidence that coronin regulates the Arp2/3 complex comes from the observation that crn1 and arp2 mutants display an allele-specific synthetic interaction. This work identifies a new form of regulation of the Arp2/3 complex and an important cellular function for coronin.
Correction of a Memory Management Method for Lock-Free Data Structures

Memory reuse in link-based lock-free data structures requires special care. Many lock-free algorithms require deleted nodes not to be reused until no active pointers point to them. Also, most lock-free algorithms use the compare_and_swap atomic primitive, which can suffer from the ``ABA problem'''' associated with memory reuse. Valois ~\cite{Valois-thesis-1995} proposed a memory management method for link-based data structures that addresses these problems. The method associates a reference count with each node of reusable memory. A node is reused only when no processes or data structures point to it. The method solves the ABA problem for acyclic link-based data structures, and allows lock-free algorithms more flexibility as nodes are not required to be freed immediately after a delete operation (e.g.\ dequeue, pop, delete min, etc.). However, there are race conditions that may corrupt data structure that use this method. In this report we correct these race conditions and present a corrected version of Valois''s method.
NextPC computation for a banked instruction cache for a VLIW architecture with a compressed encoding

VLIW architectures use very wide instruction words in conjunction with high bandwidth to the instruction cache to achieve multiple instruction issue. One instruction fetch mechanism for VLIWs is the use of a banked instruction cache. Such a cache is intended for use with a compressed instruction encoding. A compressed encoding supports variable length VLIWs and thus has associated with it the di culties in supporting variable length instructions. One of these is determining on every cycle the instruction fetch address (NextPC) for the following cycle. This report uses the TINKER experimental testbed to illustrate a mechanism that can be used by a banked instruction cache for NextPC computation. An algorithm for NextPC computation is outlined and associated hardware support is presented. Issues relating to the cycle time complexity of the proposed design are also addressed.
Ultraviolet Emission from a Diamond pn Junction

We report the realization of an ultraviolet light–emitting diode with the use of a diamond pn junction. The pn junction was formed from a boron-doped p-type diamond layer and phosphorus-doped n-type diamond layer grown epitaxially on the {111} surface of single crystalline diamond. The pn junction exhibited good diode characteristics, and at forward bias of about 20 volts strong ultraviolet light emission at 235 nanometers was observed and was attributed to free exciton recombination.
Behavioral Status of Young Adolescents with Iron Deficiency Anemia

1This study was partially supported by the Tommy Fund, Childrens Hospital of Philadelphia. Nutritional factors may affect the behavioral status and learning performance of students. One type of nutritional deviation which may occur especially during rapid maturation in early adolescence is iron deficiency anemia, a condition identified by blood indices. In a recent study of a junior high school population, Webb and Oski (1973) found that youths with iron deficiency anemia, especially males, had significantly lower scores on
Efficient Subgraph Similarity Search on Large Probabilistic Graph Databases

Many studies have been conducted on seeking the efficient solution for subgraph similarity search over certain (deterministic) graphs due to its wide application in many fields, including bioinformatics, social network analysis, and Resource Description Framework (RDF) data management. All these works assume that the underlying data are certain. However, in reality, graphs are often noisy and uncertain due to various factors, such as errors in data extraction, inconsistencies in data integration, and privacy preserving purposes. Therefore, in this paper, we study subgraph similarity search on large probabilistic graph databases. Different from previous works assuming that edges in an uncertain graph are independent of each other, we study the uncertain graphs where edges' occurrences are correlated. We formally prove that subgraph similarity search over probabilistic graphs is #P-complete, thus, we employ a filter-and-verify framework to speed up the search. In the filtering phase, we develop tight lower and upper bounds of subgraph similarity probability based on a probabilistic matrix index, PMI. PMI is composed of discriminative subgraph features associated with tight lower and upper bounds of subgraph isomorphism probability. Based on PMI, we can sort out a large number of probabilistic graphs and maximize the pruning capability. During the verification phase, we develop an efficient sampling algorithm to validate the remaining candidates. The efficiency of our proposed solutions has been verified through extensive experiments.
Standing in My Partner's Shoes: Partner Perspective Taking and Reactions to Accommodative Dilemmas

Four studies examined the role of partner perspective taking in shaping reactions to accommodative dilemmas-situations in which a close partner enacts a potentially destructive behavior. Participants included marital partners (Study 1) and dating partners (Studies 2, 3, and 4). Studies 1, 3, and 4 examined preexisting tendencies toward partner perspective taking, and Studies 2, 3, and 4 included experimental manipulations of perspective. In all four studies, adopting the partner's perspective (rather than one's own) during an accommodative dilemma resulted in (a) more positive emotional reactions, more relationship-enhancing attributions, and enhanced inclinations toward constructive responding and (b) less negative emotional reactions, less partner-blaming attributions, and reduced inclinations toward destructive responding. In Studies 2, 3, and 4, analyses examining the simultaneous effects of partner perspective taking, commitment level, and general perspective taking revealed that adopting the partner's perspective exerts unique, independent effects on accommodation-relevant emotions, attributions, and behavioral preferences.
Implicit solvent models: Combining an analytical formulation of continuum electrostatics with simple models of the hydrophobic effect

The recent development of approximate analytical formulations of continuum electrostatics opens the possibility of efficient and accurate implicit solvent models for biomolecular simulations. One such formulation (ACE, Schaefer & Karplus, J. Phys. Chem., 1996, 100:1578) is used to compute the electrostatic contribution to solvation and conformational free energies of a set of small solutes and three proteins. Results are compared to finite‐difference solutions of the Poisson equation (FDPB) and explicit solvent simulations and experimental data where available. Small molecule solvation free energies agree with FDPB within 1–1.5 kcal/mol, which is comparable to differences in FDPB due to different surface treatments or different force field parameterizations. Side chain conformation free energies of aspartate and asparagine are in qualitative agreement with explicit solvent simulations, while 74 conformations of a surface loop in the protein Ras are accurately ranked compared to FDPB. Preliminary results for solvation free energies of small alkane and polar solutes suggest that a recent Gaussian model could be used in combination with analytical continuum electrostatics to treat nonpolar interactions. ©1999 John Wiley & Sons, Inc. J Comput Chem 20: 322–335, 1999
An Interface Between Individualistic and Collectivistic Orientations in Chinese Cultural Values and Social Relations

The construct of individualism and collectivism (I/C) has been criticized for its oversimplification in categorizing cultural values. This study modifies the I/C concept in Chinese terms by connecting the traditional Chinese collectivistic orientation of yi (benevolence, righteousness, morality, faithfulness) and individualistic orientation of li (benefit, utilitarianism, profit). Twenty-eight Chinese nationals were interviewed for the purpose of examining current value orientation and social relations patterns in mainland China. The result indicates an interface between the elements of yi and li in Chinese cultural value orientations with a strong tendency moving toward utilitarian individualism in social relations. The study suggests that the I/C construct becomes culturally specific and meaningful when being connected to a culture's philosophical and rhetorical tradition and when being framed in conceptual terms that are familiar to the people and cultures under study.
Autonomously replicating single‐copy episomes in Trypanosoma brucei show unusual stability.

We have obtained several autonomously replicating plasmids in procyclic Trypanosoma brucei. Two of these have been analyzed in detail. Both exist as monomeric single‐copy episomes, which nevertheless demonstrate significant stability. These episomes transform procyclics at frequencies that are at least 60‐fold higher than those achieved earlier with non‐replicating molecules. A modified version of one of these episomes is able to replicate autonomously in bloodstream form T. brucei but it is unstable in this developmental stage of the organism. These episomes will prove useful as shuttle vectors, in functional complementation studies, in the construction of promoter‐traps for the isolation of transcriptional promoters in T. brucei, and importantly, as models for the analysis of DNA replication in this ancient eukaryotic lineage.
Mining for Social Serendipity

A common social problem at an event in which people do not personally know all of the other participants is the natural tendency for cliques to form and for discussions to mainly happen between people who already know each other. This limits the possibility for people to make interesting new acquaintances and acts as a retarding force in the creation of new links in the social web. Encouraging users to socialize with people they don't know by revealing to them hidden surprising links could help to improve the diversity of interactions at an event. The goal of this paper is to propose a method for detecting "surprising" relationships between people attending an event. By "surprising" relationship we mean those relationships that are not known a priori, and that imply shared information not directly related with the local context of the event (location, interests, contacts) at which the meeting takes place. To demonstrate and test our concept we used the Flickr community. We focused on a community of users associated with a social event (a computer science conference) and represented in Flickr by means of a photo pool devoted to the event. We use Flickr metadata (tags) to mine for user similarity not related to the context of the event, as represented in the corresponding Flickr group. For example, we look for two group members who have been in the same highly specific place (identified by means of geo-tagged photos), but are not friends of each other and share no other common interests or, social neighborhood.
Effects of Diet and/or Exercise in Enhancing Spinal Cord Sensorimotor Learning

Given that the spinal cord is capable of learning sensorimotor tasks and that dietary interventions can influence learning involving supraspinal centers, we asked whether the presence of omega-3 fatty acid docosahexaenoic acid (DHA) and the curry spice curcumin (Cur) by themselves or in combination with voluntary exercise could affect spinal cord learning in adult spinal mice. Using an instrumental learning paradigm to assess spinal learning we observed that mice fed a diet containing DHA/Cur performed better in the spinal learning paradigm than mice fed a diet deficient in DHA/Cur. The enhanced performance was accompanied by increases in the mRNA levels of molecular markers of learning, i.e., BDNF, CREB, CaMKII, and syntaxin 3. Concurrent exposure to exercise was complementary to the dietary treatment effects on spinal learning. The diet containing DHA/Cur resulted in higher levels of DHA and lower levels of omega-6 fatty acid arachidonic acid (AA) in the spinal cord than the diet deficient in DHA/Cur. The level of spinal learning was inversely related to the ratio of AA∶DHA. These results emphasize the capacity of select dietary factors and exercise to foster spinal cord learning. Given the non-invasiveness and safety of the modulation of diet and exercise, these interventions should be considered in light of their potential to enhance relearning of sensorimotor tasks during rehabilitative training paradigms after a spinal cord injury.
A Grading System for Secondary Music Groups

Typical Problems Systems based on the accumulation of points for various aspects of the program are often too cumbersome to maintain. Systems based on written tests in many instances never quite ring true to our basic instinct regarding the students who are really responsible for the group's success (or failure). Too many times, students who have no sense of tone or technique or no sense of commitment or responsibility get the highest scores on the written tests. On the other hand, grading systems based totally on performance tests often penalize students who have timid personalities or little performance experience but, nevertheless, show strong musicianship or leadership and a high level of dedication. Another bothersome aspect of most grading systems is the intimidation factor in which the students appear to be the victims and we, the directors, seem to
Body Fat Accumulation in Zebrafish Is Induced by a Diet Rich in Fat and Reduced by Supplementation with Green Tea Extract

Fat-rich diets not only induce obesity in humans but also make animals obese. Therefore, animals that accumulate body fat in response to a high-fat diet (especially rodents) are commonly used in obesity research. The effect of dietary fat on body fat accumulation is not fully understood in zebrafish, an excellent model of vertebrate lipid metabolism. Here, we explored the effects of dietary fat and green tea extract, which has anti-obesity properties, on body fat accumulation in zebrafish. Adult zebrafish were allocated to four diet groups and over 6 weeks were fed a high-fat diet containing basal diet plus two types of fat or a low-fat diet containing basal diet plus carbohydrate or protein. Another group of adult zebrafish was fed a high-fat diet with or without 5% green tea extract supplementation. Zebrafish fed the high-fat diets had nearly twice the body fat (visceral, subcutaneous, and total fat) volume and body fat volume ratio (body fat volume/body weight) of those fed low-fat diets. There were no differences in body fat accumulation between the two high-fat groups, nor were there any differences between the two low-fat groups. Adding green tea extract to the high-fat diet significantly suppressed body weight, body fat volume, and body fat volume ratio compared with the same diet lacking green tea extract. 3-Hydroxyacyl-coenzyme A dehydrogenase and citrate synthase activity in the liver and skeletal muscle were significantly higher in fish fed the diet supplemented with green tea extract than in those fed the unsupplemented diet. Our results suggest that a diet rich in fat, instead of protein or carbohydrate, induced body fat accumulation in zebrafish with mechanisms that might be similar to those in mammals. Consequently, zebrafish might serve as a good animal model for research into obesity induced by high-fat diets.
Religiosity, happiness, health, and psychopathology in a probability sample of Muslim adolescents

The aim of the present study was to explore the religiosity associations with the self-rating scales of happiness, mental health, physical health, anxiety, and depression. A sample (N = 6,339) of Muslim Kuwaiti adolescents was recruited. Their ages ranged from 15 to 18. They responded to four self-rating scales to assess religiosity, happiness, mental health, and physical health, as well as the Kuwait University Anxiety Scale, and the Center for Epidemiologic Studies-Depression Scale. Boys had higher mean scores on happiness, mental health, and physical health than did girls, whereas girls had higher mean scores on religiosity, anxiety, and depression. All the correlations were significant in both sexes. They were positive between each of the self-rating scales of religiosity, happiness, mental health, and physical health, and negative between these four rating scales and both anxiety and depression. A high-loaded and bipolar factor was disclosed and labelled “Religiosity and well-being vs. psychopathology. ” In the stepwise regression, the main predictor of religiosity was happiness in both sexes.
Culturally Relevant Pedagogy and the Public Speaking Classroom

Course: Public Speaking Objectives: Students will: (1) understand the tools of a good public speaker in a real world/service-learning context; (2) develop critical thinking skills as a speaker and a listener; (3) examine the connection between ability to communicate and role as a mentor/role model to others; and (4) develop speeches in both Eurocentric and other culturally relevant forms of speaking
Astrovirus as a cause of gastroenteritis in Japan

We used an enzyme immunoassay (EIA) to screen for astrovirus in stool specimens from outbreaks and sporadic cases of gastroenteritis collected between 1982 and 1992 in six prefectural public health institutes in Japan. Three outbreaks of gastroenteritis involving schoolchildren and adults were confirmed to be attributable to astrovirus. Astrovirus was detected in 6 to 10% of the specimens from patients with sporadic gastroenteritis from whom no other bacterial or viral agent had been identified. Among the sporadic cases, astrovirus was most frequently detected in infants less than 1 year of age, and the incidence peaked in March and April. Using specimens from recent outbreaks, we found that the EIA was more sensitive than electron microscopy (EM) for the detection of astrovirus, and many EM-negative specimens were positive by EIA. However, some stool specimens previously found to have astrovirus-like particles by EM were negative by EIA, perhaps because of inadequate storage conditions, such as long-term storage and repeated freezings and thawings. Our results indicate that astrovirus is more commonly associated with childhood gastroenteritis than has been previously appreciated and suggest that further studies to examine the epidemiology and disease burden of this virus are needed.
L3: Sensing driving conditions for vehicle lane-level localization on highways

When vehicle road-level localization cannot satisfy people's need for convenience and safety driving, lane-level localization becomes a corner stone in Intelligent Transportation System. Existing work on tracking vehicles on lane-level mostly depends on pre-deployed infrastructures and additional hardwares. In this paper, we utilize smartphone sensing of driving conditions for vehicle lane-level localization on highways. We analyze the driving traces collected from real driving environments, finding that each type of lane change has its unique pattern on the vehicle's lateral acceleration. Based on this observation, we propose a Lane-Level Localization (L3) system, which can perform real-time vehicle localization on lane-level only using smartphones when vehicles are driving on highways. Our system first uses embedded sensors in smartphones to capture the patterns of lane change behaviors. Then a Gaussian Distribution is employed to track vehicles on lane-level with tolerance of false detections. Extensive experiments demonstrate that L3 is accurate and robust in real driving environments. The experimental results show that, on average, L3 achieves accuracy of 91.49% on lane change detection and 86.94% on lane-level localization.
“Autoimmune(-Like)” Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis

Idiosyncratic drug-induced liver injury (DILI) and hepatic injury due to herbal and dietary supplements (HDS) can adapt clinical characteristics of autoimmune hepatitis (AIH), such as the appearance of autoantibodies and infiltration of the liver by immune competent cells. To describe these cases of DILI/HDS, the poorly-defined term “autoimmune(-like)” DILI/HDS came up. It is uncertain if these cases represent a subgroup of DILI/HDS with distinct pathomechanistic and prognostic features different from “classical” DILI/HDS. Besides, due to the overlap of clinical characteristics of “immune-mediated” DILI/HDS and AIH, both entities are not easy to differentiate. However, the demarcation is important, especially with regard to treatment: AIH requires long-term, mostly lifelong immunosuppression, whereas DILI/HDS does not. Only through exact diagnostic evaluation, exclusion of differential diagnoses and prolonged follow-up can the correct diagnosis reliably be made. Molecular mechanisms have not been analysed for the subgroup of “autoimmune(-like)” DILI/HDS yet. However, several pathogenetic checkpoints of DILI/HDS in general and AIH are shared. An analysis of these shared mechanisms might hint at relevant molecular processes of “autoimmune(-like)” DILI/HDS.
Hash Joins and Hash Teams in Microsoft SQL Server

The query execution engine in Microsoft SQL Server employs hash-based algorithms for inner and outer joins, semi-joins, set operations (such as intersection), grouping, and duplicate removal. The implementation combines many techniques proposed individually in the research literature but never combined in a single implementation, neither in a product nor in a research prototype. One of the paper’s contributions is a design that cleanly integrates most existing techniques. One technique, however, which we call hash teams and which has previously been described only in vague terms, has not been implemented in prior research or product work. It realizes in hash-based query processing many of the benefits of interesting orderings in sort-based query processing. Moreover, we describe how memory is managed in complex and bushy query evaluation plans with multiple sort and hash operations. Finally, we report on the effectiveness of hashing using two very typical database queries, including the performance effects of hash teams.