Miracle-dz/UniFAR-FTUs huggingface dataset:
Betel nut chewing, oral premalignant lesions, and the oral microbiome

Oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (HPV), and areca (betel) nut. Although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. An investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. Study participants were recruited from a dental clinic in Guam. Structured interviews and oral examinations were performed. Oral swabbing and saliva samples were evaluated by 454 pyrosequencing of the V3- V5 region of the 16S rRNA bacterial gene and genotyped for HPV. One hundred twenty-two adults were enrolled including 64 current betel nut chewers, 37 former chewers, and 21 with no history of betel nut use. Oral premalignant lesions, including leukoplakia and submucous fibrosis, were observed in 10 chewers. Within-sample bacterial diversity was significantly lower in long-term (≥10 years) chewers vs. never chewers and in current chewers with oral lesions vs. individuals without lesions. Between-sample bacterial diversity based on Unifrac distances significantly differed by chewing status and oral lesion status. Current chewers had significantly elevated levels of Streptococcus infantis and higher and lower levels of distinct taxa of the Actinomyces and Streptococcus genera. Long-term chewers had reduced levels of Parascardovia and Streptococcus. Chewers with oral lesions had significantly elevated levels of Oribacterium, Actinomyces, and Streptococcus, including Streptococcus anginosus. In multivariate analyses, controlling for smoking, oral HPV, S.anginosus, and S. infantis levels, current betel nut chewing remained the only predictor of oral premalignant lesions. Our study provides evidence that betel nut chewing alters the oral bacterial microbiome including that of chewers who develop oral premalignant lesions. Nonetheless, whether microbial changes are involved in betel nut-induced oral carcinogenesis is only speculative. Further research is needed to discern the clinical significance of an altered oral microbiome and the mechanisms of oral cancer development in betel nut chewers.
Who Votes for chavismo?: Class Voting in Hugo Chávez's Venezuela

The conventional wisdom about contemporary Venezuelan politics is that class voting has become commonplace, with the poor doggedly supporting Hugo Chávez while the rich oppose him. This class voting is considered both a new feature of Venezuelan politics and a puzzle given the multiclass bases of prior populist leaders in Latin America. I clarify the concept of class voting by distinguishing between monotonic and nonmonotonic associations between class and vote choice. Using survey data, I find that only in Chávez's first election in 1998 was class voting monotonic. Since then, class voting in Venezuela has been nonmonotonic, with the very wealthiest Venezuelans disproportionately voting against Chávez. At the same time, Chávez's support appears to have increased most among the middle sectors of the income distribution, not the poorest. Finally, I find that whatever effect Chávez may have had on overall turnout, his efforts have not disproportionately mobilized poor voters.
Structural basis for DNA strand separation by a hexameric replicative helicase

Hexameric helicases are processive DNA unwinding machines but how they engage with a replication fork during unwinding is unknown. Using electron microscopy and single particle analysis we determined structures of the intact hexameric helicase E1 from papillomavirus and two complexes of E1 bound to a DNA replication fork end-labelled with protein tags. By labelling a DNA replication fork with streptavidin (dsDNA end) and Fab (5′ ssDNA) we located the positions of these labels on the helicase surface, showing that at least 10 bp of dsDNA enter the E1 helicase via a side tunnel. In the currently accepted ‘steric exclusion’ model for dsDNA unwinding, the active 3′ ssDNA strand is pulled through a central tunnel of the helicase motor domain as the dsDNA strands are wedged apart outside the protein assembly. Our structural observations together with nuclease footprinting assays indicate otherwise: strand separation is taking place inside E1 in a chamber above the helicase domain and the 5′ passive ssDNA strands exits the assembly through a separate tunnel opposite to the dsDNA entry point. Our data therefore suggest an alternative to the current general model for DNA unwinding by hexameric helicases.
Intrinsic Predictors of Lateral Ankle Sprain in Adolescent Dancers: A Prospective Cohort Study

Objective:To identify intrinsic predictors of lateral ankle sprain. Design:Prospective cohort study. Setting:A performing arts secondary school and a dance school. Participants:One hundred fifteen adolescent dancers (94 female and 21 male) entered the study. One ankle of each dancer was randomly assigned to a test group (n = 114), and the other was assigned to a validation group (n = 112). Predictors:Eighteen measures, including age, dance history, previous ankle sprain, ankle and foot laxity and range of motion, and balance from test ankles were entered into a backwards stepwise Cox regression model. The model generated with the test group was used to predict ankle sprains in the validation group. Main Outcome Measure:Time to first lateral ankle sprain. Results:An increased risk of sprain in the test group was predicted by younger age [hazard ratio (HR) = 0.65, 95% CI 0.45-0.94], previous sprain of the contralateral ankle (HR = 3.76, CI 1.24-11.40), increased passive inversion range (HR = 1.06, CI 1.00-1.12), and inability to balance on demipointe (HR = 3.75, CI 1.02-13.73). Of these predictors, only previous sprain of the contralateral ankle significantly predicted ankle sprain in the validation group (HR = 3.90, CI 1.49-10.22). The predictive accuracy of this variable was not strong (positive likelihood ratio of 2.01 and negative likelihood ratio of 0.45). Conclusion:A history of previous lateral ankle sprain is associated with an increase in the risk of future sprain of the contralateral ankle.
Studies on inflammation and wound healing: angiogenesis and collagen synthesis stimulated in vivo by resident and activated wound macrophages.

Wound inflammatory cells were harvested by aspiration of fluid from the "dead space" of subcutaneous rabbit wounds and transplanted into the cornea where, compared with suitable controls, they stimulated healing (i.e., angiogenesis, fibroplasia, and new collagen synthesis, which led to formation of visible, vascularized scar tissue). Analysis of the data and the literature supports the conclusions that: (1) inflammatory cells control the continuation of the repair process after the immediate effects of injury subside; (2) macrophages, as opposed to granulocytes, appear to be the major contributors; (3) activated by their presence in the wound, macrophages release substances that stimulate fibroplasia, collagen synthesis, and angiogenesis in vivo; and (4) tissue injury is not a maximum stimulus to repair, since endotoxin-treated macrophages have increased capacity to stimulate collagen synthesis and angiogenesis. A hypothesis is offered to explain the notorious clinical discrepancy between the extent of injury and the extent of repair.
Cortical Responses to Aδ-Fiber Stimulation: Magnetoencephalographic Recordings in a Subject Lacking Large Myelinated Afferents

Controversy persists over the role of the primary somatosensory cortex (SI) in processing small-fiber peripheral afferent input. We therefore examined subject I.W, who, due to sensory neuronopathy syndrome, has no large-fiber afferents below C3 level. Cortical evoked responses were recorded with a whole-scalp neuromagnetometer to high-intensity electrical stimulation of the distal right radial, median, and tibial nerves and skin over the forearm and mechanical stimulation of (neurologically intact) lip. The responses to electrical stimulation in the Aβ-denervated limbs peaked at 110–140 ms in contralateral SI and at 140–220 ms in contralateral secondary somatosensory cortex (SII), consistent with Aδ-mediated input. I.W. was able to localize pin-prick stimuli with 4 cm accuracy. Responses to laser stimuli on the radial dorsum of the hand peaked in contralateral SII cortex at 215 ms, also compatible with Aδ-mediated input. These results support the role of the SI cortex in processing the sensory discriminative aspects of Aδ-mediated input.
A naturalistic study of early lexical development: General processes and inter-individual variations in French children

This study investigated early lexical development in French by analysing changes and variability in lexical production and composition of children’s spontaneous speech samples from three age groups: 1;8, 2;6 and 3;3 years (20 children in each). Analyses of general developmental changes showed that lexical productivity increased strongly between 1;8 and 2;6 and between 2;6 and 3;3. Changes in lexical composition mostly occurred between 1;8 and 2;6, indicating that the most important reorganizations are achieved by 2;6. The main changes observed (decreases in proportions of nouns and paralexical classes, and increases in proportions of predicate and grammatical classes) fit overall the developmental trajectories found for other languages, such as English and Italian. Two controversial issues were particularly examined and discussed with regard to cognitive, language-specific and methodological factors: noun-verb asynchrony and grammatical word explosion. Quantitative individual differences in lexical composition were greater at 1;8 than at 2;6 and 3;3, supporting the hypothesis that stylistic variation decreases in the course of the third year. Children’s lexical profiles were strikingly diversified at 1;8, whereas they appeared as variants of a same ‘grammatical profile’ at 2;6 and 3;3. We propose that the decline of stylistic variations reflects the impact of developmental constraints, such as the necessity for children to produce function words, which suggests that variations found in the youngest children are not determinant factors for subsequent lexical development.
Mechanical thrombectomy devices for endovascular management of acute ischemic stroke: Duke stroke center experience

BACKGROUND Mechanical thrombectomy devices are gaining popularity in large vessel occlusions where chemical thrombolysis is usually futile. MERCI, Multi-MERCI, Penumbra and SWIFT trails have elevated the status of mechanical thrombectomy from being a complementary treatment modality to mainstream stroke intervention. The aim of this study was to compare our immediate recanalization rates with available mechanical devices. MATERIALS AND METHODS A retrospective review from March 2009 to August 2012 was performed on patients who underwent mechanical thrombectomy for large vessel occlusion. Cases where IATPA and/or balloon angioplasty was performed without mechanical thrombectomy were excluded from the study. Recanalization rates were assessed immediately post-procedure by follow-up angiography. TICI scores were used to quantify the extent of recanalization and the residual clot burden. RESULTS Twenty two procedures were performed on 20 patients using Merci (MER):5; Penumbra (PEN):11; Solitaire-FR (SOL):6. Two patients underwent intervention using both Merci and Penumbra devices. The M:F ratio was 1.2:1. The most common vascular territory involved was the right MCA (9/20) followed by left MCA (5/20), left ICA (2/20), basilar (3/20) and vertebral arteries (1/20). The average door to needle time was 210 minutes [MER: 184.4; PEN: 249.2; SOL: 162]. Additional procedures were performed in 63.4% (14/22) of the patients [MER: 80% (4/5); PEN: 72.7% (8/11) and SOL: 33.3% (2/6)]. Vasospasm was observed in MER: 20% (1/5); PEN: 9.1% (1/11); SOL: 0% (0/6)]. Complete recanalization was achieved in 59.1% (13/22) [MER: 40% (2/5); PEN: 45.5% (5/11); SOL: 100% (6/6)]. The rate of complete recanalization was statistically significant for the Solitaire group vs. the MERCI group (P=0.0062) as well as the Penumbra group (0.0025). The average pre-procedure TICI was 0.4 [MER: 0.6; PEN: 0.3; SOL: 0.3], while the average post-procedure TICI was 2.5 [MER: 2.4; PEN: 2.3; SOL: 3.0]. CONCLUSIONS The study reveals a higher rate of angiographic recanalization using the Solitaire-FR device, requiring a lesser number of passes and other associated procedures as compared to MERCI and Penumbra. Thus, Stentrievers (Solitaire-FR) are advantageous in faster device delivery and quick flow restoration. However, future prospective randomized large trials are required to confirm these early results.
Protease-activated receptor-2 involvement in hypotension in normal and endotoxemic rats in vivo.

BACKGROUND The protease-activated receptor-2 (PAR-2) is expressed by vascular endothelial cells and upregulated by lipopolysaccharide (LPS) in vitro. PAR-2 is activated by a tethered ligand created after proteolytic cleavage by trypsin or experimentally by a synthetic agonist peptide (PAR-2AP) corresponding to the new amino terminus of the tethered ligand. METHODS AND RESULTS Intravenous administration of PAR-2AP (0.1, 0.3, and 1 mg/kg) to rats caused a dose-dependent hypotension. A scrambled peptide was without effect. A specific trypsin inhibitor, biotin-SGKR-chloromethylketone, inhibited trypsin-induced hypotension but not that stimulated by PAR-2AP. In animals treated with LPS 20 hours earlier, we found an increased sensitivity to trypsin and PAR-2AP in the hypotensive response. In particular, PAR-2AP caused hypotension at a low concentration of 30 ng/kg. Moreover, PAR-2 was immunolocalized to endothelial and smooth muscle cells in aorta and jugular vein in LPS-treated rats, and increased levels of PAR-2 mRNA were shown by reverse transcription-polymerase chain reaction analysis. CONCLUSIONS Our findings suggest that PAR-2 is important in the regulation of blood pressure in vivo. A functional upregulation of PAR-2 by LPS was demonstrated by the activity of concentrations of PAR-2AP that were inactive in normal animals. We conclude that PAR-2 may play an important role in the hypotension associated with endotoxic shock and may represent a new therapeutic target.
Sexual arousal to nonsexual violence and sadomasochistic themes among rapists and non sex-offenders.

Twenty heterosexual rapists, 10 non-sex-offender patients from the same maximum security psychiatric institution, and 10 men with low socioeconomic status recruited from the local community were presented with audiotaped narrations while their penile tumescence was measured. The story categories were as follows: female victim/partner (neutral situation, consenting sex, rape, nonsexual violence, consenting bondage and spanking, masochistic bondage and spanking, and nonconsenting bondage and spanking) and male victim/partner (neutral situation, consenting sex, rape, and nonsexual violence). There were no differences between the two non-sex-offender groups, and they were combined. Rapists showed more sexual arousal to rape descriptions and less to consenting sex stories than the control subjects. As predicted, rapists were sexually aroused by stories involving nonsexual violence with female but not male victims. Surprisingly, there were no differences between rapists and control subjects in their responsiveness to the spanking and bondage stories. It was concluded that the amount of violence in the rape descriptions is critical in differentiating rapists from non-sex-offenders.
A dynamic security traversal mechanism for providing deterministic delay guarantee in SDN

For security concerns, a security traversal service can route data flows through a sequences of security devices (middleboxes). In this paper, we identify the problem of delay guarantee in security traversal and propose a scheme to dynamically change the security traversal path. To provide deterministic delay guarantee with minimum virtual machine (VM) and transmission cost, we model this security traversal path determination as a constrained shortest path problem (CSP) and propose an optimal security traversal with middlebox addition (OSTMA) mechanism. Besides, we implement the proposed OSTMA mechanism in an OpenFlow network by designing a centralized security traversal controller to dynamically monitor the network condition information and reconfigure the security traversal path. Our experimental results show that the proposed dynamic security traversal scheme can still achieve delay requirements for network topology changes and burst traffic.
Convergence Analysis of a Class of Nonsmooth Gradient Systems

In this paper, we present new results on convergence of a class of nonlinear dynamical systems modeled by the gradients of nonsmooth cost functions. This class of systems arises from neural-network research and can be regarded as a generalization of existing neural-network models. Using the recently developed Lstrokojasiewicz gradient inequality, the convergence analysis of this gradient-like differential inclusion is given. Without assuming the smoothness of the cost function or analyticity of the activation function, we prove the output convergence of the differential system. In addition, for the piecewise analytic activation function with positive first-order derivative, we prove the state convergence. Furthermore, we also discuss the relationship between the convergence rate and the location of terminal limit point. Numerical examples are provided to illustrate the theoretical results and present the goal-seeking capability of the systems.
The impact of interpersonal style and perceived coercion on aggression and self-harm in personality-disordered patients admitted to a secure psychiatric hospital

Recent research on aggressive behaviour in psychiatric hospitals has emphasised the importance of the interaction between characteristics of patients and the hospital environment. Interpersonal style, a key component of personality and personality disorder, has emerged as a potentially important characteristic that may be relevant to a patient's interactions with the hospital environment. Interpersonal style affects how patients relate to others and how they respond to the demands of treatment. This study explored the impact of interpersonal style and perceptions of staff coercion on aggression and self-harm. Participants were 39 patients with personality disorder admitted involuntarily to a secure psychiatric hospital. Results showed that perceptions of coercion were high but unrelated to aggression and self-harm. Interpersonal style did not relate to perceived coercion. However, patients with a more coercive interpersonal style, as measured by the Chart of Interpersonal Reactions in Closed Living Environments, were more likely to self-harm and/or act aggressively. Possible implications for the treatment of aggressive individuals and the prevention of aggressive behaviour are made.
Requirements for NuMA in maintenance and establishment of mammalian spindle poles

Microtubules of the mitotic spindle in mammalian somatic cells are focused at spindle poles, a process thought to include direct capture by astral microtubules of kinetochores and/or noncentrosomally nucleated microtubule bundles. By construction and analysis of a conditional loss of mitotic function allele of the nuclear mitotic apparatus (NuMA) protein in mice and cultured primary cells, we demonstrate that NuMA is an essential mitotic component with distinct contributions to the establishment and maintenance of focused spindle poles. When mitotic NuMA function is disrupted, centrosomes provide initial focusing activity, but continued centrosome attachment to spindle fibers under tension is defective, and the maintenance of focused kinetochore fibers at spindle poles throughout mitosis is prevented. Without centrosomes and NuMA, initial establishment of spindle microtubule focusing completely fails. Thus, NuMA is a defining feature of the mammalian spindle pole and functions as an essential tether linking bulk microtubules of the spindle to centrosomes.
Integrated CMOS Energy Harvesting Converter With Digital Maximum Power Point Tracking for a Portable Thermophotovoltaic Power Generator

This paper presents an integrated maximum power point tracking system for use with a thermophotovoltaic portable power generator. The design, implemented in 0.35-μm CMOS technology, consists of a low-power control stage and a dc-dc boost power stage with soft-switching capability. With a nominal input voltage of 1 V, and an output voltage of 4 V, we demonstrate a peak conversion efficiency under nominal conditions of over 94% (overall peak efficiency over 95%), at a power level of 300 mW. The control stage uses lossless current sensing together with a custom low-power time-based analog-to-digital converter to minimize control losses. The converter employs a fully integrated digital implementation of a peak power-tracking algorithm, and achieves a measured tracking efficiency above 98%. A detailed study of achievable efficiency versus inductor size is also presented, with the calculated and measured results.
Role-based multi-robot exploration

The advent of robotic technologies means that teams of robots can be used for an ever wider range of tasks, such as exploration of unknown terrain, search and rescue in disaster scenarios, and inspection of hazardous areas. In many such applications, partial or full autonomy is a desirable characteristic for the robots, since this can reduce the load on human operators and improve the speed and quality of team coordination. However, in many scenarios the environments of interest may contain significant communication challenges due to their size or complexity, introducing the need for robust methods for communication-limited exploration by multiple robots. This thesis proposes “Role-Based Exploration”, a novel exploration algorithm for multi-robot systems that aims to efficiently gather information obtained by all members of the team in a single location. In Role-Based Exploration, some of the robots in the team explore the environment while others act as mobile relays, ferrying information back and forth within the team. By imposing a team hierarchy, choosing clever locations for robots to meet, and applying some simple rules that allow robots to exchange places within this hierarchy, a robust exploration system emerges that reactively adjusts to communication availability and to the shape of the environment. Role-Based Exploration demonstrates several advantages over other methods, particularly as communication becomes less reliable. New information obtained by the team is brought to a single location quickly and in regular intervals, team members share information well and often, and the full team effort can be easily monitored and controlled. The approach has been implemented and compared to competing algorithms both in simulation, and on a team of Pioneer robots.