Miracle-dz/UniFAR-FTUs huggingface dataset:
An internet-based program to enhance motivation to change in females with symptoms of an eating disorder: a randomized controlled trial

Background Previous research has demonstrated an association between low motivation to change and an unfavorable treatment outcome in patients with an eating disorder. Consequently, various studies have examined the effects of motivational enhancement therapy (MET) on motivation to change and treatment outcome in eating disorders. In each of these studies, MET was administered in a face-to-face setting. However, because of its anonymity and ease of access, the internet provides several advantages as the format for such an intervention. Therefore, the current study investigated the effects of an internet-based program (‘ESS-KIMO’) to enhance motivation to change in eating disorders. Method In total, 212 females were accepted for participation and assigned randomly to the intervention condition (n = 103) or waiting-list control condition (n = 109). The intervention consisted of six online MET sessions. Before and after the intervention or waiting period respectively, participants completed the Eating Disorder Examination Questionnaire (EDE-Q), the Stages of Change Questionnaire for Eating Disorders (SOCQ-ED), the Pros and Cons of Eating Disorders Scale (P-CED), the Self-Efficacy Scale (SES), and the Rosenberg Self-Esteem Scale (RSES). A total of 125 participants completed the assessment post-treatment. Completer analyses and intent-to-treat analyses were performed. Results Significant time × group interactions were found, indicating a stronger increase in motivational aspects and self-esteem, in addition to a stronger symptom reduction on some measures from pre- to post-treatment in the intervention group compared to the control group. Conclusions Internet-based approaches can be considered as useful for enhancing motivation to change in eating disorders and for yielding initial symptomatic improvement.
A new online method for event detection and tracking: empirical evidence from the French stock market

In this article we propose a new approach in event studies based on a hidden Markov chain combined with a classical event study model. The number of states informs us about the number of significant events affecting the related market, and the identification of the hidden states determines exactly the delimiters of the event period. Studying each state parameters allows us to examine the events' effect on the related market and to compare results to traditional event analysis. Extensive Monte Carlo simulations and preliminary examination of real data in the French stock market show promising results.
Clinical significance of the presence of anti-human leukocyte antigen-donor specific antibody in kidney transplant recipients with allograft dysfunction

Background/Aims This study investigated the clinical significance of detecting anti-human leukocyte antigen-donor specific antibody (HLA-DSA) in kidney transplant recipients (KTRs) requiring indication biopsy owing to allograft dysfunction. Methods We analyzed the presence of HLA-DSA in 210 KTRs who took indication biopsy. We divided these cases into two groups, HLA-DSA (+) (n = 52) and HLA-DSA (–) (n = 158) group, and compared the clinical characteristics, pathological findings, and clinical outcomes of the two groups. Results The rates of retransplant, pretransplant sensitization, and HLA-mismatch were significantly higher in HLA-DSA (+) group than in HLA-DSA (–) group (p < 0.05 for each comparison). In histologic finding, all types of rejections were more frequent in the former group. Besides, scores of both the T-cell injury markers such as tubulitis, interstitial inf lammation, and vasculitis and antibody-mediated injury markers such as peritubular C4d deposition and microvascular inflammation (glomerulitis plus peritubular capillaritis) were higher in HLA-DSA (+) group (p < 0.05 for each). Notably, allograft outcomes were worse in HLA-DSA (+) group. Further, multivariate analysis showed that presence of HLA-DSA, advanced interstitial fibrosis/tubular atrophy (interstitial fibrosis plus tubular atrophy ≥ 2), and allograft rejection in biopsy were independent risk factors for allograft failure. Conclusions The results of this study showed that presence of HLA-DSA in a case of allograft dysfunction adversely influences allograft outcome, and its detection, irrespective of the result of the allograft biopsy, necessitates intensive monitoring and treatment.
Career Mobility, Job Match, and Overeducation

Many workers are mismatched with their jobs. While many factors contribute to mismatch, overeducation is attracting increased attention. Several reasons have been put forth to explain why overeducation exists in the labor market. Sicherman [1991] hypothesizes that overeducation may be part of a career mobility process. Workers temporarily accept jobs for which they are overqualified in exchange for training. This paper reports on alternative tests examining the career mobility hypothesis. Overeducated workers appear more likely to move to better jobs over time. However, contrary to the career mobility hypothesis, they are less likely than adequately educated workers to feel that the skills they are acquiring will help them on future jobs.
Factors influencing farmer migration in Norway: A study based on survey results linked to financial data

Abstract This paper studies what factors influence farmers to leave their farms, and how financial issues are linked with this behaviour. A data set is constructed by linking survey results with financial data, and the data set is analysed by multivariate statistical techniques. Our results indicate that, while existence and size of future farm production is important, there is also a difference between farmers who primarily have financial objectives for their farming and those who have more lifestyle oriented objectives. Everything else being equal, the latter group is more likely to stay on the farm. This could imply that, if preventing migration from rural to urban areas is a policy objective, production support schemes will be effective for some groups, but will be less effective for the group with lifestyle objectives. If this group is to be encouraged to stay in the countryside, policies directed at improving the general living conditions in the local community are likely to be more effective than specific support schemes related to agricultural production.
The Market Timing Power of Moving Averages: Evidence from US REITs and REIT Indexes

I present evidence that a moving average (MA) trading strategy dominates buying and holding the underlying asset in a mean-variance sense using monthly returns of value-weighted and equal-weighted US REIT indexes over the period January 1980 until December 2010. The abnormal returns are largely insensitive to the four Carhart factors and produce economically and statistically significant alphas of between 10 and 15% per year after transaction costs. This performance is robust to different lags of the MA and in subperiods while investor sentiment, liquidity risks, business cycles, up and down markets, and the default spread cannot fully account for its performance. The MA strategy works just as well with randomly generated returns and bootstrapped returns. The substantial market timing ability of the MA strategy appears to be the main driver of the abnormal returns. The returns to the MA strategy resemble the returns of an imperfect at-the-money protective put strategy relative to the underlying portfolio. The lagged signal to switch has substantial predictive power over the subsequent return of the REIT index. The MA strategy avoids the sharp downturn at the beginning of 2008 and substantially outperforms the cumulative returns of the buy-and-hold strategy using all of the 20 REIT indexes. The results from applying the MA strategy with 274 individual REITs largely corroborate the findings for the REIT indexes.
Value of Fecal Calprotectin as a Biomarker for Juvenile Polyps in Children Investigated With Colonoscopy

Objectives: The clinical presentation of colonic juvenile polyps with abdominal discomfort and occult rectal bleedings make them difficult to recognize. The aim of this study was to report the clinical features of colonic juvenile polyps in children referred to colonoscopy and evaluate fecal calprotectin (FCP) as a screening biomarker for their diagnosis. Methods: The study included a total of 266 children (range 3.1–19.0 years, median age 15.8 years) investigated with ileocolonoscopy; of whom, 239 (89%) were investigated for inflammatory bowel disease (IBD). FCPs were analyzed as a marker of colonic inflammation, and levels <50 mg/kg was considered to be negative. Results: Juvenile polyps were detected in 12 (4.5%) children; the remaining 67 (25.2%) had Crohn disease, 57 (21.4%) ulcerative colitis, 5 (1.9%) unclassified IBD, 4 (1.5%) allergic colitis, bleeding source was localized in 6 (2.3%), and 115 (43.2%) had unspecific or normal findings. FCP was available in 203 (76.3%) children before colonoscopy; levels of FCP were higher in children with juvenile polyps (range 28–2287 mg/kg, median 844 mg/kg) compared with those with normal colonoscopies (range <20–2443 mg/kg, median 130 mg/kg, P < 0.0001), but not compared with those with active IBD (range <20–7780 mg/kg, median 962 mg/kg, P = 0.6299). FCPs were available in 9 of 12 children after polypectomy, of whom all had their FCP levels significantly reduced (range 0–281 mg/kg, median 49 mg/kg, P < 0.0001). Conclusions: Colonic juvenile polyps are frequently found in pediatric patients presenting with hematochezia and elevated FCP levels. Colonic juvenile polyps are difficult to differentiate from pediatric IBD without a colonoscopy.
Toward a Global Theory of Cross-Border and Multilevel Corporate Political Activity

A proposed global theory of corporate political activity (CPA) analyzes the complex resource allocation choices involved in integrating politically relevant cross-border and multilevel strategies for multinational enterprises (MNEs). Cross-border CPA is “horizontal” allocation of scarce corporate resources by MNEs to politically relevant strategies across multiple countries. Globalization reshapes CPA among multiple levels functioning below, at, and above national governments. Subnational communities and international policy regimes, supranational quasigovernmental institutions, and supranational nongovernmental organizations all affect businesses. Multilevel CPA is “vertical” allocation of scarce corporate resources to politically relevant strategies among subnational, national, regional, and global levels. Furthermore, in each country and at each level, business-relevant policies are determined in multiple policy arenas, shaped by widely differing nonmarket institutions, corruption conditions, and stakeholder demands for corporate social responsibility. Multiple policy “arena” allocation adds to the analytical complexity of the CPA strategizing problem. Implications for scholarship and practice are presented.
Further Investigations into the Factors Affecting Compliance with U.K. Fishing Quotas

This paper reports the results of a more recent study of quota compliance in the U.K. fishery that was investigated in an earlier article in this journal (Hatcher et al. 2000). The study collected more detailed data on fishermen’s perceptions and experience of enforcement and sought to measure the financial incentive to cheat. In addition, whereas the earlier study used a binary approach to modelling the data, we employed an ordered-response model and included a number of scale regressors without transformation. Although we still find some evidence of normative influences on violation levels, the results suggest that “conventional” economic incentives predominate in the fishery. (JEL Q22)
Using the Kalman Filter to Smooth the Shocks of a Dynamic Stochastic General Equilibrium Model

This paper shows how to use the Kalman filter (Kalman 1960) to back out the shocks of a dynamic stochastic general equilibrium model. In particular, we use the smoothing algorithm as described in Hamilton (1994) to estimate the shocks of a sticky-prices and sticky-wages model using all the information up to the end of the sample.
Spatial Proximity Rather Than Temporal Frequency Determines the Wagon Wheel Illusion

A rotating disk composed of alternating light and dark segments may give rise to the wagon wheel illusion: a perceptual reversal in rotation direction. Continuously illuminated (eg in daylight) as well as discretely presented (eg stroboscopic or computer-animated) versions of the illusion exist; here, we investigated the discrete version. Prominence of the illusion is commonly believed to depend on temporal frequency of rotation, but frequency effects have been unsystematic across previous experiments. Here, illusion strength is shown instead to lawfully depend on an attraction function of angular displacement between successive frames (experiments 1 and 2). We studied the illusion across a wider range of this factor than previously and as a result obtained unusually strong effects (up to 100% reversal). In two further experiments we showed that this is because the effect of the attraction function on the wagon wheel illusion strength is modulated by a perceived increase in the number of spokes of the wheel, a phenomenon generally known as the frequency doubling illusion. These factors combine to offer a unifying explanation of the wagon wheel illusion, at least under discrete presentation and possibly under continuous presentation conditions as well.
Mate choice for more melanin as a mechanism to maintain a functional oncogene

The mechanisms by which cancer evolves and persists in natural systems have been difficult to ascertain. In the Xiphophorus melanoma model, a functional oncogene (Xiphophorus melanoma receptor kinase Xmrk) has been maintained for several million years despite being deleterious and in an extremely unstable genomic region. Melanomas in Xiphophorus spp. fishes (platyfishes and swordtails) have been investigated since the 1920s, and, yet, positive selection that could explain the maintenance of Xmrk has not been found. Here, we show that Xiphophorus cortezi females from two populations prefer males with the spotted caudal (Sc) melanin pattern, which is associated with the presence of the Xmrk oncogene and serves as the site of melanoma formation within this species. Moreover, X. cortezi females prefer males with an enhanced Sc to males with a reduced Sc pattern. RT-PCR analysis confirms tissue-specific Xmrk expression within the Sc pattern in X. cortezi. Because of the association of Xmrk with the Sc pigment pattern and the fact that melanoma formation augments this visual signal, sexual selection appears to be maintaining this oncogene because of a mating preference for Sc, as well as the exaggeration of this male trait. At the individual level, decreases in viability and fecundity because of Xmrk and subsequent melanoma formation may be mitigated via increases in mate acquisition. At the population level, maintenance of this oncogene appears to be under frequency dependent selection, as we detected female preference for males without Sc in a third population that had higher frequencies of Sc in females.
Functional Interaction between c-Src and Its Mitotic Target, Sam 68 (*)

The c-Src tyrosine kinase phosphorylates and binds to a 68-kDa RNA-binding protein in mitotic cells. We have examined the mechanism and functional consequence of the interaction of c-Src with this protein, Sam 68 (Src associated in mitosis, 68 kDa). In whole cell homogenates, Sam 68 was the predominant substrate and binding partner of overexpressed c-Src. Mitotic, tyrosine-phosphorylated Sam 68 bound selectively to recombinant SH2 domains with significantly different affinities (c-Src ≈ Ras GTPase activating protein > p85α (amino-terminal) > Grb2 p85α (COOH-terminal)). In vitro translated Sam 68 also bound selectively to recombinant SH3 domains, with the highest affinity for the Src and p85α SH3 domains. SH3 binding was inhibited by specific Sam 68 peptides. In vitro translated Sam 68 bound directly to immobilized poly(U), and this was inhibited by binding of Src and p85 SH3 domains to Sam 68. The results suggest that the selection of Sam 68 as a mitotic target by c-Src is the result of highly specific interaction with SH2 and SH3 domains and that this interaction may modulate the RNA binding activity of Sam 68.
An “optimal” k-needle placement strategy and its application to guiding transbronchial needle aspirations

This article addresses the problem of finding an “optimal” strategy for placing k biopsy needles, given a large number of possible initial needle positions. We consider two variations of the problem: (1) Calculate the smallest set of needles necessary to guarantee a successful biopsy; and (2) Given a number k, calculate k needles such that the probability of a successful biopsy is maximized. Note that “needle” is used as shorthand for the parameter vector that specifies the needle placement. Both problems are formulated in terms of two general, NP-hard optimization problems. Our k-needle placement strategy can be considered as “optimal” in the sense that we are able to formulate it as a known NP-hard problem for which it is believed (NP≠P conjecture) that no efficient algorithm exists that computes the optimal solution. In other words, our strategy is “optimal” with respect to the best approximative algorithm known for the respective NP-hard problem. For the second variation we have implemented an approximative algorithm that is guaranteed to be within a factor of≈0.63 of the exact solution. Given a number k, the algorithm calculates k sets of parameters, each set specifying the placement of a needle and the corresponding probability of success. The resulting probabilities show that our approach can provide valuable decision support for the physician in choosing how many needles to place and how to place them. A typical example of a biopsy where the initial needle position is known approximately is a transbronchial needle aspiration (TBNA). We demonstrate how our “optimal” needle placement strategy can be used to achieve sensor-less guidance of TBNA. The basic idea is to use a patient-specific model of the tracheobronchial tree (from CT/MR) and our model for flexible endoscopes to preoperatively estimate the unknown position of the bronchoscope. The result is a set of candidate shapes for the unknown shape of the bronchoscope before needle placement or, in other words, a (large) number of possible initial needle positions. By parameterizing the handling of the bronchoscope, including the insertion of the biopsy needle, we are able to apply our “optimal” strategy. The result is a TBNA protocol that, if executed during the procedure, prescribes how to handle the bronchoscope to maneuver the needle into the target. With the aforementioned endoscope model, we present a new way of modeling long, flexible instruments. The algorithm requires no initialization or preprocessing and calculates the workspace of an instrument based on its insertion depth and a set of internal and external constraints.
Technological self-reliance for Latin America: the OAS contribution

Making technology autonomous from the influence of investors and proprietors in developed countries has emerged as one of the core themes in the doctrine of dependence. Technology is not only machinery; it is “a major resource for creating new wealth; it is an instrument allowing its owners to exercise social control in various forms; it decisively affects modes of decision making. …” It is seen as the key to achieving “integral development,” free from the abuses associated with the past patterns of technology transfer which were largely mediated by multinational corportions: excessive foreign exchange costs, rise in unnecessary imports, production of luxury goods, neglect of employment objectives, stagnation of the agricultural sector, excessive urbanization, insufficient use of local professionals, environmental degradation, and lack of sensitivity to local cultures. In Marxist versions of dependence-thinking the older pattern of technology transfer strengthened the enclave economy and its comprador bourgeoisie, rather than aiding the development of a national bourgeoisie and of a modern working class.
MyBI: A Business Intelligence application development framework for Malaysian public sector

The public sector faces great challenges in strengthening the public services. Therefore, public servants need more accurate and up-to-date information that can be accessed at any time, and able to reach internal and external information for effective and efficient decision making. Business Intelligence (BI) provides decision makers with valuable knowledge to meet their needs. However, studies related to BI are still lacking, particularly in the Malaysian public sector. This paper introduces a framework for BI application development for the Malaysian public sector (MyBI). This framework requires two main processes for an organization to produce a successful BI application, in terms of the development and implementation, consist of the assessment of organizational readiness for BI and BI application development. To test and validate the proposed framework, a web-based BI application prototype is developed using open source software and has been tested using Computer System Usability Questionnaires (CSUQ) to measure the users' satisfaction and usability.
Is Government Spending at the Zero Lower Bound Desirable?

We build a medium-scale DSGE model and calibrate it to fit the main macroeconomic variables during the US Great Recession. Using it to evaluate the welfare effects of increasing government consumption at the zero lower bound beyond what was actually observed in the data, we reach three main results. First, the increase in government consumption after 2008, albeit small in present value terms, was close to optimal. Second, frontloading the same stimulus would have been welfare-improving. Third, larger welfare effects occur in our model for parameter values implying either large welfare costs of modest recessions (e.g., high consumption curvature), or outright large recessions. (JEL E12, E32, E43, E62, H50)
Accurate recapture identification for genetic mark–recapture studies with error-tolerant likelihood-based match calling and sample clustering

Error-tolerant likelihood-based match calling presents a promising technique to accurately identify recapture events in genetic mark–recapture studies by combining probabilities of latent genotypes and probabilities of observed genotypes, which may contain genotyping errors. Combined with clustering algorithms to group samples into sets of recaptures based upon pairwise match calls, these tools can be used to reconstruct accurate capture histories for mark–recapture modelling. Here, we assess the performance of a recently introduced error-tolerant likelihood-based match-calling model and sample clustering algorithm for genetic mark–recapture studies. We assessed both biallelic (i.e. single nucleotide polymorphisms; SNP) and multiallelic (i.e. microsatellite; MSAT) markers using a combination of simulation analyses and case study data on Pacific walrus (Odobenus rosmarus divergens) and fishers (Pekania pennanti). A novel two-stage clustering approach is demonstrated for genetic mark–recapture applications. First, repeat captures within a sampling occasion are identified. Subsequently, recaptures across sampling occasions are identified. The likelihood-based matching protocol performed well in simulation trials, demonstrating utility for use in a wide range of genetic mark–recapture studies. Moderately sized SNP (64+) and MSAT (10–15) panels produced accurate match calls for recaptures and accurate non-match calls for samples from closely related individuals in the face of low to moderate genotyping error. Furthermore, matching performance remained stable or increased as the number of genetic markers increased, genotyping error notwithstanding.