Miracle-dz/UniFAR-FTUs huggingface dataset:
Energy-efficient joint unicast and multicast beamforming with multi-antenna user terminals

This paper studies energy-efficient joint transmit and receive beamforming in multi-cell multi-user multiple-input multiple-output systems. We consider conventional network energy efficiency metric where the users can receive unicasting streams in addition to the group-specific common multicasting streams which have certain rate constraints. The goal is to use the transmission resources more efficiently to improve the energy efficiency, when the users are equipped with multiple antennas. Numerical results show the achieved energy efficiency gains by using the additional degrees of freedom of the multicasting transmission to private message unicasting.
Targeted oncolytic herpes simplex virus type 1 eradicates experimental pancreatic tumors.

As many other cancers, pancreatic ductal adenocarcinoma (PDAC) progression is associated with a series of hallmark changes for cancer cells to secure their own growth success. Yet, these very changes render cancer cells highly sensitive to viral infection. A promising strategy may rely on and exploit viral replication for tumor destruction, whereby infection of tumor cells by a replication-conditional virus may lead to cell destruction and simultaneous release of progeny particles that can spread and infect adjacent tumor cells, while sparing healthy tissues. In the present study, we used Myb34.5, a second-generation replication-conditional herpes simplex virus type 1 (HSV-1) mutant in which ICP6 gene expression is defective and expression of the HSV-1 γ134. 5 gene is regulated by the cellular B-myb promoter. We found that B-myb is present in experimental PDAC and tumors, and is overexpressed in patients' tumors, as compared with normal adjacent pancreas. Myb34.5 replicates to high level in human PDAC cell lines and is associated with cell death by apoptosis. In experimental models of PDAC, mice receiving intratumoral Myb34.5 injections appeared healthy and tumor progression was inhibited, with evidence of tumor necrosis, hemorrhage, viral replication, and cancer cell death by apoptosis. Combining standard-of-care chemotherapy with Myb34.5 successfully led to a very impressive antitumoral effect that is rarely achieved in this experimental model, and resulted in a greater reduction in tumor growth than chemotherapy alone. These promising results warrant further evaluation in early phase clinical trial for patients diagnosed with PDAC for whom no effective treatment is available.
Timbre Synthesis Technology and its Application to Computer Music Compositions

This paper introduces the timbre synthesis technologies developed so far from the standpoint of composers. That is, the classification is based upon musical function. It also introduces major compositions in which new timbres synthesized by those technologies form the main structural core. Timbre synthesis technologies referred to here are granular synthesis, morphing and sound hybridization, which are based on various analysis/synthesis signal models such as LPC and sinusoidal models.
rhEGF-containing thermosensitive and mucoadhesive polymeric sol–gel for endoscopic treatment of gastric ulcer and bleeding

Gastrointestinal endoscopy is a standard diagnostic tool for gastrointestinal ulcers and cancer. In this study, we have developed recombinant human epidermal growth factor-containing ulcer-coating polymeric sol–gel for endoscopic application. Chitosan and pluronic F127 were employed for their thermoresponsive and bioadhesive properties. At temperatures below 21℃, polymeric sol–gel remains liquid during endoscopic application and transforms to gel at body temperature after application on ulcers. In an in vitro cellular wounding assay, recombinant human epidermal growth factor sol–gel significantly enhanced the cell migration and decreased the wounding area (68%) compared to nontreated, recombinant human epidermal growth factor solution, and sol–gel without recombinant human epidermal growth factor (42, 49, and 32 % decreased at day 1). The in vivo ulcer-healing study was performed in an acetic acid-induced gastric ulcer rat model and proved that our recombinant human epidermal growth factor endoscopic sol–gel facilitated the ulcer-healing process more efficiently than the other treatments. Ulcer sizes in the recombinant human epidermal growth factor sol–gel group were decreased 2.9- and 2.1-fold compared with those in the nontreated group on days 1 and 3 after ulceration, respectively. The mucosal thickness in the recombinant human epidermal growth factor sol–gel group was significantly increased compared to that in the nontreated group (3.2- and 6.9-fold on days 1 and 3 after ulceration, respectively). In a gastric retention study, recombinant human epidermal growth factor sol–gel stayed on the gastric mucosa more than 2 h after application. The present study suggests that recombinant human epidermal growth factor sol–gel is a prospective candidate for treating gastric ulcers via endoscopic application.
Red Blood Cell Product Transfusion Thresholds and Clinical Outcomes

Objective: To determine whether patients transfused red blood cell (RBC) products according to guideline-specified pretransfusion hemoglobin (Hb) concentrations or for other reasons were more likely to survive their intensive care unit (ICU) stay. Design: An observational study of 375 478 episodes of ICU care, over 5 years, was performed with ICU survival as the primary outcome. Outcomes were analyzed as a function of pretransfusion Hb concentration for groups with distinct transfusion indications while adjusting for potential confounders. Setting and Patients: This study included all adult patients discharged from 1 of 203 adult ICUs from 32 US health-care systems. The patients were from community hospitals, tertiary, and academic medical centers. Intervention: Transfusion of allogenic packed RBCs or whole blood was prescribed at the discretion of the treating clinicians. Measurements and Main Results: We found that 15% of adult ICU patients are transfused RBC products, and most transfusions for hemodynamically stable patients are administered above the guideline-specified pretransfusion Hb threshold of 7 g/dL. Hemodynamically stable patients transfused below this threshold were significantly more likely to survive their ICU stay than those not transfused (odds ratio [OR] 0.59, 95% confidence interval [CI], 0.43-0.81; P = .001), and patients transfused at thresholds above 9 g/dL were less likely to survive their ICU stay than those not transfused. Patients of the acute blood loss group who were transfused appeared to benefit or were not harmed by transfusion. Conclusion: Conservative RBC product transfusion practices for groups that are targeted by guidelines are justified by outcomes observed in clinical practice. This study provides evidence for the liberal administration of RBC products to critically ill adults with acute blood loss based on association with lower risk of mortality.
Complex Contribution of the 3′-Untranslated Region to the Expressional Regulation of the Human Inducible Nitric-oxide Synthase Gene

Cytokine stimulation of human DLD-1 cells resulted in a marked expression of nitric-oxide synthase (NOS) II mRNA and protein accompanied by only a moderate increase in transcriptional activity. Also, there was a basal transcription of the NOS II gene, which did not result in measurable NOS II expression. The 3′-untranslated region (3′-UTR) of the NOS II mRNA contains four AUUUA motifs and one AUUUUA motif, known to destabilize the mRNAs of proto-oncogenes, nuclear transcription factors, and cytokines. Luciferase reporter gene constructs containing the NOS II 3′-UTR showed a significantly reduced luciferase activity. The embryonic lethal abnormal vision (ELAV)-like protein HuR was found to bind with high affinity to the adenylate/uridylate-rich elements of the NOS II 3′-UTR. Inhibition of HuR with antisense constructs reduced the cytokine-induced NOS II mRNA, whereas overexpression of HuR potentiated the cytokine-induced NOS II expression. This provides evidence that NOS II expression is regulated at the transcriptional and post-transcriptional level. Binding of HuR to the 3′-UTR of the NOS II mRNA seems to play an essential role in the stabilization of this mRNA.
Mechanism of augmented rate of left ventricular filling during exercise.

At rest, most of left ventricular (LV) filling occurs early in diastole. This LV filling occurs in response to the pressure gradient produced as LV pressure falls below left atrial (LA) pressure. Because mitral valve flow occurs in response to an LA to LV pressure gradient, augmented diastolic mitral valve flow during exercise may be due to an increased mitral valve pressure gradient resulting from a rise in LA pressure and/or a fall in LV early diastolic pressure. Accordingly, we studied 13 conscious dogs, instrumented to measure micromanometer LV and LA pressures, and determined LV volume from three ultrasonic dimensions during exercise. The animals ran on a treadmill for 8-15 minutes at 5-8 miles/hr. With reflexes intact, during exercise, the heart rate increased from 116 +/- 20 to 189 +/- 24 beats per minute (mean +/- SD, p less than 0.01), the maximum rate of change of LV volume (dV/dtmax) increased from 185 +/- 44 to 282 +/- 76 ml/sec (p less than 0.01), the ejection fraction and cardiac output increased, and the duration of diastole decreased from 296 +/- 83 to 162 +/- 71 msec (p less than 0.01). Mitral valve opening pressure, mean LA pressure (10.9 +/- 4.4 versus 10.2 +/- 3.9 mm Hg, p = NS), and LV end-diastolic pressure (12.8 +/- 4.8 versus 13.1 +/- 3.3 mm Hg, p = NS) were all relatively unchanged. The time constant of the fall of isovolumic LV pressure decreased from 28 +/- 3.3 to 21 +/- 4.4 msec (p less than 0.05). The early diastolic portion of the LV pressure-volume loop was shifted downward during exercise, with the minimum LV pressure decreasing from 3.3 +/- 2.8 to -2.8 +/- 3.4 mm Hg (p less than 0.05) and the maximum mitral valve pressure gradient increasing from 5.5 +/- 1.7 to 11.8 +/- 3.5 mm Hg (p less than 0.01). A similar downward shift of the early diastolic portion of the LV pressure-volume loop was produced by infusion of dobutamine (6 micrograms/kg/min i.v.) at rest, as well as by exercise when the heart rate was held constant by right ventricular pacing at 190-210 beats per minute. The downward shift during exercise was prevented by beta-blockade (metoprolol, 0.5 mg/kg i.v.). We conclude that during exercise, sympathetic stimulation and tachycardia produce a downward shift of the early diastolic portion of the LV pressure-volume loop. (ABSTRACT TRUNCATED AT 400 WORDS)
Study on the value of serum miR-106b for the early diagnosis of hepatocellular carcinoma

AIM To analyze the incidence of hepatocellular carcinoma (HCC) in a population that underwent health checkups and had high serum miR-106b levels. METHODS A total of 335 subjects who underwent checkups in the Digestive and Liver Disease Department of our hospital were randomly selected. RT-PCR was used to detect the level of miR-106b in serum samples. Laboratory and imaging examinations were carried out to confirm the HCC diagnosis in patients who had a > 2-fold change in miR-106b levels. Ultrasound-guided biopsy was also used for HCC diagnosis when necessary. On this basis, the clinical data of these subjects, including history of hepatitis virus infection, obesity, long-term history of alcohol use and stage of HCC, were collected. Then, the impact of these factors on the level of miR-106b in serum was analyzed. Furthermore, receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic efficacy of miR-106b for HCC. RESULTS A total of 35 subjects had abnormal serum miR-106b levels, of which 20 subjects were diagnosed with HCC. t-test revealed that the difference in serum miR-106b level in terms of sex, age, history of hepatitis virus infection, obesity and long-term history of alcohol use was not statistically significant. However, serum miR-106b levels in patients with advanced HCC (stage III/IV) was higher than in patients with early HCC (stage I/II), and the difference was statistically significant (P = 0.000). Moreover, the ROC curve revealed that the area under the curve value for miR-106b was 0.885, which shows that serum miR-106b level has a certain clinical value for HCC diagnosis. CONCLUSION The random sampling survey shows that serum miR-106b level is a valuable diagnostic marker for HCC. However, the diagnostic threshold value needs to be further researched.
Anticoagulation monitoring during extracorporeal circulation with the Hepcon/HMS device

Objective: The objective of our study was to compare the standard protocol of anticoagulation to the Hepcon/HMS. Method: This study included forty-four patients who underwent coronary bypass grafting surgery (CABG), or biological aortic valve replacement (AVR). Unfractionated heparin (UH) was used for patients who underwent operations in the control group (n = 22) (300U/Kg of UH with a goal of an ACT of 400s). The heparin was antagonized dose/dose by protamine. For the patients who underwent operations in the HMS group (n = 22), the heparin and protamine doses were assessed by the Hepcon/HMS device. Results: The sex ratio amounted to 1.93 (29 men and 15 women) and the mean age was 70 ± 11 years. The patients in the HMS group had a chest closure time that was significantly shorter than patients in the control group. The times were, respectively, 42 ± 15 minutes and 68 ± 27 minutes (p = 0.001). The protamine/heparin ratio was significantly lower in the HMS group (0.62 ± 0.13 vs. 1 ± 0.11) (p = 0.0001). The postoperative bleeding amounted to 804 ± 729 ml in the HMS group versus 1416 ± 1103 in the control group (p = 0.016). In multivariate linear regression analysis, only two independent factors were significantly associated with bleeding: the Hepcon/HMS (OR = 0.1-p = 0.03) and the preoperative hemoglobin rate (OR = 1.4 - p = 0.05). Postoperatively, within 72 hours, the red blood cell transfusion was 1.04 ± 1.5 units for the HMS group and 2.1 ± 1.87 units for the control group (p = 0.05). Conclusion: During cardiac surgery under CPB, heparin and protamine titration with the Hepcon/HMS device could predict a lower protamine dose and lower postoperative bleeding without higher thromboembolic events, and lower perioperative red blood cell transfusion with a shorter chest closure time.
System-on-chip-based hardware acceleration for human detection in 2D/3D scenes

A system-on-chip field gate programmable array (FPGA)-based video processing platform for human detection in complex scenes is presented. This study details the hardwarebased implementation of a human detection algorithm in 2D/3D scenes, including the capture, video processing, and display stages. The proposed method is implemented by extending a previously proposed method that uses features extracted from the Riemannian manifold of region covariance matrices computed from 2D data. The proposed method considers both 2D and depth data (3D). The LogitBoost classifier is employed to detect humans. The proposed implementation uses minimal resources and employs a pipeline technique for better performance and operation.
A cable driven parallel robot for coconut farm

This paper presents a cable driven parallel robot for automating the process of coconut dehusking in large and medium sized farms. The robot assists the mechanized dehusking process by performing the activity of fetching coconuts from a heap and autonomously loading them into a dehusking machine's hopper. The idea is to have the existing dehusking machines to be setup right next to a coconut heap in a farmland and get the dehusking operation done with minimum human assistance. The use of a cable robot system in such highly unstructured environment requires it to be portable and reconfigurable. An efficient anchor point estimation technique and installation procedure is presented in the paper along with the system concept. The paper also discusses the kinematic design and workspace analysis of the proposed cable robot.
Towards a proof of the 2-to-1 games conjecture?

We present a polynomial time reduction from gap-3LIN to label cover with 2-to-1 constraints. In the “yes” case the fraction of satisfied constraints is at least 1 −ε, and in the “no” case we show that this fraction is at most ε, assuming a certain (new) combinatorial hypothesis on the Grassmann graph. In other words, we describe a combinatorial hypothesis that implies the 2-to-1 conjecture with imperfect completeness. The companion submitted paper [Dinur, Khot, Kindler, Minzer and Safra, STOC 2018] makes some progress towards proving this hypothesis. Our work builds on earlier work by a subset of the authors [Khot, Minzer and Safra, STOC 2017] where a slightly different hypothesis was used to obtain hardness of approximating vertex cover to within factor of √2−ε. The most important implication of this work is (assuming the hypothesis) an NP-hardness gap of 1/2−ε vs. ε for unique games. In addition, we derive optimal NP-hardness for approximating the max-cut-gain problem, NP-hardness of coloring an almost 4-colorable graph with any constant number of colors, and the same √2−ε NP-hardness for approximate vertex cover that was already obtained based on a slightly different hypothesis. Recent progress towards proving our hypothesis [Barak, Kothari and Steurer, ECCC TR18-077], [Dinur, Khot, Kindler, Minzer and Safra, STOC 2018] directly implies some new unconditional NP-hardness results. These include new points of NP-hardness for unique games and for 2-to-1 and 2-to-2 games. More recently, the full version of our hypothesis was proven [Khot, Minzer and Safra, ECCC TR18-006].
SEASONAL VARIATION OF CHEMICAL COMPOSITION AND DRY MATTER DIGESTIBILITY OF RANGELANDS IN NW GREECE

This study was carried out to determine the chemical composition and in vitro dry matter digestibility of grazable material, during the growing season of plants, in three different altitudinal zones, in native rangelands, northwestern Greece. Samples were collected during the period from May to October of the years 2004 and 2005. Sample collection was accomplished by cutting aboveground biomass at a height similar to that grazed by small ruminants. The results showed that herbage production was significantly affected (P<0.001) by sampling year, growing season and altitudinal zone respectively, as well as (P<0.01) by the “month x year” and (P<0.05) “altitude x month” interactions. CP, ash, EE and CF content and IVDMD affected significantly (P<0.01) by both harvest month and altitudinal zone, while there was no significant affection by the sampling year and the interaction between altitude, month and year (except EE which affected (P<0.01) by the “month x year” interaction). Herbage production strongly related (P<0.01) to the altitude (r= +0.247), harvest month (r= -0.479) and CP content (r= -0.274). IVDMD related positively (P<0.01) to CP (r= +0.729), ash (r= +0.369) and EE (r= +0.351) content and negatively to harvest month (r= -0.779) and to CF content (r= -0.663). It was recommended that additional protein sources should be supplied in order to cover the needs of the grazing animals. It is necessary the transhumance of herds from lower to higher altitude for better utilization of rangelands.
A fast, on-line collision avoidance method for a kinematically redundant manipulator based on reflex control

A computationally efficient method to achieve reflexive collision avoidance is described. The system consists of four parallel, asynchronous control layers: a conventional servo tracking controller, a reactive trapezoidal velocity profiler, a joint-by-joint reflexive collision avoidance layer, and a guiding potential-function layer. The lowest two layers guarantee that the robot will not overshoot any joint-space position setpoint. The higher two layers compute successive set points based on a continuous, online inspection of configuration space. The guiding potential-function layer incorporates task-space-based attraction to a hand goal, while the reflexes permit use of kinematic redundancy for obstacle avoidance. In many cases, no explicit path planning is required to achieve competent, collision-free motion to a task-space goal while moving in a cluttered environment. Experimental results are described for the physical implementation of the system on the first four joints of a kinematically redundant robot. <<ETX>>
Siderophore activity of pyoverdin for Pseudomonas aeruginosa

Pseudomonas aeruginosa produces an extracellular compound with yellowish green fluorescence, called pyoverdin, which functions as a siderophore. The production of pyoverdin, formerly called fluorescein, is concomitant with the production of another siderophore, pyochelin. Pyoverdin is produced by P. aeruginosa in several forms, some of which were separated on gel filtration columns and on reverse-phase, high-pressure liquid chromatography columns. An active form of iron-free pyoverdin was purified to homogeneity. The elution of pyoverdin from the columns was monitored for absorbance, fluorescence, and siderophore activities. These activities, iron binding, and the stimulation of bacterial iron transport indicated that pyoverdin can function as a siderophore for P. aeruginosa. The siderophore function of pyoverdin may be related to the pathogenicity of this bacterium because pyoverdin stimulated growth not only in iron-deficient culture medium, but also in defined medium containing transferrin and in human serum or plasma.
Assessing the performance of Olelo, a real-time biomedical question answering application

Question answering (QA) can support physicians and biomedical researchers to find answers to their questions in the scientific literature. Such systems process large collections of documents in real time and include many natural language processing (NLP) procedures. We recently developed Olelo, a QA system for biomedicine which includes various NLP components, such as question processing, document and passage retrieval, answer processing and multi-document summarization. In this work, we present an evaluation of our system on the the fifth BioASQ challenge. We participated with the current state of the application and with an extension based on semantic role labeling that we are currently investigating. In addition to the BioASQ evaluation, we compared our system to other on-line biomedical QA systems in terms of the response time and the quality of the answers.
Evaluating Clusterings by Estimating Clarity

In this thesis I examine clustering evaluation, with a subfocus on text clusterings specifically. The principal work of this thesis is the development, analysis, and testing of a new internal clustering quality measure called informativeness. I begin by reviewing clustering in general. I then review current clustering quality measures, accompanying this with an in-depth discussion of many of the important properties one needs to understand about such measures. This is followed by extensive document clustering experiments that show problems with standard clustering evaluation practices. I then develop informativeness, my new internal clustering quality measure for estimating the clarity of clusterings. I show that informativeness, which uses classification accuracy as a proxy for human assessment of clusterings, is both theoretically sensible and works empirically. I present a generalization of informativeness that leverages external clustering quality measures. I also show its use in a realistic application: email spam filtering. I show that informativeness can be used to select clusterings which lead to superior spam filters when few true labels are available. I conclude this thesis with a discussion of clustering evaluation in general, informativeness, and the directions I believe clustering evaluation research should take in the future.