Miracle-dz/UniFAR-FTUs huggingface dataset:
Simplified Process Model Discovery Based on Role-Oriented Genetic Mining

Process mining is automated acquisition of process models from event logs. Although many process mining techniques have been developed, most of them are based on control flow. Meanwhile, the existing role-oriented process mining methods focus on correctness and integrity of roles while ignoring role complexity of the process model, which directly impacts understandability and quality of the model. To address these problems, we propose a genetic programming approach to mine the simplified process model. Using a new metric of process complexity in terms of roles as the fitness function, we can find simpler process models. The new role complexity metric of process models is designed from role cohesion and coupling, and applied to discover roles in process models. Moreover, the higher fitness derived from role complexity metric also provides a guideline for redesigning process models. Finally, we conduct case study and experiments to show that the proposed method is more effective for streamlining the process by comparing with related studies.
A Cognitive Prototype Model of Moral Judgment and Disagreement

Debates about moral judgments have raised questions about the roles of reasoning, culture, and conflict. In response, the cognitive prototype model explains that over time, through training, and as a result of cognitive development, people construct notions of blameworthy and praiseworthy behavior by abstracting out salient properties that lead to an ideal representation of each. These properties are the primary features of moral prototypes and include social context interpretation, intentionality, consent, and outcomes. According to this model, when the properties are uniform and coherent, they depict a promoral or immoral prototype, relative to the orientations of the properties. A promoral prototype is represented by an action that is supported by the culture, intentionally benevolent or other-regarding, consensual, and resulting in positive outcomes. An immoral prototype is an action that is condemned by the culture, intentionally malevolent or self-serving, lacking consent, and resulting in negative outcomes. It is hypothesized that moral prototypes will result in a high level of agreement and require effortless processing. Alternatively, when properties conflict or the situation deviates from the prototype, a nonprototype will result. It is hypothesized that nonprototypical situations will act as a source of moral disagreement and may require more effortful processing.
The Directional Hierarchical AODV (DH-AODV) routing protocol for wireless mesh networks

Wireless mesh networks (WMNs) can be considered as a key technology for next-generation wireless networking. However, field trials and experiments prove that the performance of WMNs still below expectations. Therefore, several challenging research issues need to be determined. The routing protocol is one of the important factors to be improved to be robust, scalable, secured and efficient. This paper aims to design and implement a routing protocol that improves the scalability of the WMNs. The Directional Hierarchical AODV (DH-AODV) routing protocol is proposed taking advantage of the existing fields of the control packets in the AODV in order to reduce the load on the network's bandwidth and to quickly detect route breakage. The proposed protocol is designed, implemented and evaluated using Qualnet Simulator. The Ad-hoc on Demand Distance Vector (AODV) is selected as a benchmark. The simulation results indicate that this enhanced routing protocol can 47% reduce the end-to-end delay of data packets, improve the throughput by 11.2%, and decrease the packet loss rate 20% less than the standard AODV.
Branch-hopped wavelet packet division multiplexing

Wavelet packet division multiplexing (WPDM) is a high-capacity, flexible and robust orthogonal multiplexing technique in which wavelet packet basis functions are chosen as the coding waveforms. By analogy with frequency-hopped communication schemes, incorporation of time variation into the WPDM scheme offers the potential for further performance improvements, especially in frequency-selective fading channels. We consider a 'branch-hopped' WPDM scheme which employs an efficient modular switched transmultiplexer structure to induce the time variation. We determine classes of 'slow' and 'fast' hopping schemes analogous to their frequency-hopped counterparts, and evaluate several switching strategies for the transmultiplexer. For a given switching strategy we then design the filters within the transmultiplexer modules to provide further robustness to frequency-selective fading channels.
I want this place to thrive: Volunteering, co-production and creative labour

Until now geographical research on creative labour has tended to characterise it either in terms of �hot� jobs in buzzing places or precarious, often poorly paid working conditions. This article argues for a subtler consideration of the complex combination of factors at play within the cultural ecology of art-making. The lure of creative labour has been explained by three key rationales: intrinsic motivators of personal satisfaction and social status; risk-taking; and the challenging, self-affirming nature of creative work. Place-making is advanced here as a fourth rationale for volunteering in creative labour. The co-production of Yorkshire Sculpture Park as an affective, practised and material (art) place is explored through the new concept of embodied and emotional philanthropy. Capturing the unbounded and processual qualities of place-making, this paper provides insights into how volunteers labour beside the artist and paid workers to help co-create an internationally renowned art and environmental attraction. Philanthropy is therefore opened from referring to rich, individualistic donors, to include those who gift time, passion and labour. The paper also argues that volunteering, as a form of gifting, is especially significant during times of economic instability.
Neural Network Approach to Word Category Prediction for English Texts

Word category prediction is used to implement an accurate word recognition system. Traditional statistical approaches require considerable training data to estimate the probabilities of word sequences, and many parameters to memorize probabilities. To solve this problem, NETgram, which is the neural network for word category prediction, is proposed. Training results show that the performance of the NETgram is comparable to that of the statistical model although the NETgram requires fewer parameters than the statistical model. Also the NETgram performs effectively for unknown data, i.e., the NETgram interpolates sparse training data. Results of analyzing the hidden layer show that the word categories are classified into linguistically significant groups. The results of applying the NETgram to HMM English word recognition show that the NETgram improves the word recognition rate from 81.0% to 86.9%
Introducing Queer Theory into the Undergraduate Classroom: Abstractions and Practical Applications

"Queer theory" as a label for a new critical reading practice means at least three different things: (1) "queer theory" as a theory of the queer, the odd, the abnormal and a theory privileging that perspective or experience; (2) "queer theory" understood as a queer different, atypical kind of theory; and (3) "queer theory" where "queer" operates as an imperative to "queer" or defamiliarize theory, making its assumptions and occlusions subject to analysis. In queer theoretical work, all of these definitions are discernible and manifest in interesting ways. According to the first sense listed above, queer theorists foreground the queer, by which I mean not only the explicitly homoerotic and the various ways in which persons come to inhabit a gender and a sexuality, but also the odd and abnormal as well as the disgusting, ambivalent, or perverse. In looking at exceptional and abject, queer theory frequently discovers what is essential to the dominant and unqueer. Noting how what is queer or perverse is often presupposed by the normal and sacred, queer theory explodes the center/margin or privileged/subordinated paradigms
Protoporphyrins Enhance Oligomerization and Enzymatic Activity of HtrA1 Serine Protease

High temperature requirement protein A1 (HtrA1), a secreted serine protease of the HtrA family, is associated with a multitude of human diseases. However, the exact functions of HtrA1 in these diseases remain poorly understood. We seek to unravel the mechanisms of HtrA1 by elucidating its interactions with chemical or biological modulators. To this end, we screened a small molecule library of 500 bioactive compounds to identify those that alter the formation of extracellular HtrA1 complexes in the cell culture medium. An initial characterization of two novel hits from this screen showed that protoporphyrin IX (PPP-IX), a precursor in the heme biosynthetic pathway, and its metalloporphyrin (MPP) derivatives fostered the oligomerization of HtrA1 by binding to the protease domain. As a result of the interaction with MPPs, the proteolytic activity of HtrA1 against Fibulin-5, a specific HtrA1 substrate in age-related macular degeneration (AMD), was increased. This physical interaction could be abolished by the missense mutations of HtrA1 found in patients with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). Furthermore, knockdown of HtrA1 attenuated apoptosis induced by PPP-IX. These results suggest that PPP-IX, or its derivatives, and HtrA1 may function as co-factors whereby porphyrins enhance oligomerization and the protease activity of HtrA1, while active HtrA1 elevates the pro-apoptotic actions of porphyrin derivatives. Further analysis of this interplay may shed insights into the pathogenesis of diseases such as AMD, CARASIL and protoporphyria, as well as effective therapeutic development.
Collected Extensions to IMAP4 ABNF

Over the years, many documents from IMAPEXT and LEMONADE working groups, as well as many individual documents, have added syntactic extensions to many base IMAP commands described in RFC 3501. For ease of reference, this document collects most of such ABNF changes in one place. This document also suggests a set of standard patterns for adding options and extensions to several existing IMAP commands defined in RFC 3501. The patterns provide for compatibility between existing and future extensions. This document updates ABNF in RFCs 2088, 2342, 3501, 3502, and 3516. It also includes part of the errata to RFC 3501. This document doesn't specify any semantic changes to the listed RFCs. [STANDARDS-TRACK]
EIN3 and ORE1 Accelerate Degreening during Ethylene-Mediated Leaf Senescence by Directly Activating Chlorophyll Catabolic Genes in Arabidopsis

Degreening, caused by chlorophyll degradation, is the most obvious symptom of senescing leaves. Chlorophyll degradation can be triggered by endogenous and environmental cues, and ethylene is one of the major inducers. ETHYLENE INSENSITIVE3 (EIN3) is a key transcription factor in the ethylene signaling pathway. It was previously reported that EIN3, miR164, and a NAC (NAM, ATAF, and CUC) transcription factor ORE1/NAC2 constitute a regulatory network mediating leaf senescence. However, how this network regulates chlorophyll degradation at molecular level is not yet elucidated. Here we report a feed-forward regulation of chlorophyll degradation that involves EIN3, ORE1, and chlorophyll catabolic genes (CCGs). Gene expression analysis showed that the induction of three major CCGs, NYE1, NYC1 and PAO, by ethylene was largely repressed in ein3 eil1 double mutant. Dual-luciferase assay revealed that EIN3 significantly enhanced the promoter activity of NYE1, NYC1 and PAO in Arabidopsis protoplasts. Furthermore, Electrophoretic mobility shift assay (EMSA) indicated that EIN3 could directly bind to NYE1, NYC1 and PAO promoters. These results reveal that EIN3 functions as a positive regulator of CCG expression during ethylene-mediated chlorophyll degradation. Interestingly, ORE1, a senescence regulator which is a downstream target of EIN3, could also activate the expression of NYE1, NYC1 and PAO by directly binding to their promoters in EMSA and chromatin immunoprecipitation (ChIP) assays. In addition, EIN3 and ORE1 promoted NYE1 and NYC1 transcriptions in an additive manner. These results suggest that ORE1 is also involved in the direct regulation of CCG transcription. Moreover, ORE1 activated the expression of ACS2, a major ethylene biosynthesis gene, and subsequently promoted ethylene production. Collectively, our work reveals that EIN3, ORE1 and CCGs constitute a coherent feed-forward loop involving in the robust regulation of ethylene-mediated chlorophyll degradation during leaf senescence in Arabidopsis.
Brain Pharmacokinetics of Ganciclovir in Rats with Orthotopic BT4C Glioma

Ganciclovir (GCV) is an essential part of the Herpes simplex virus thymidine kinase (HSV-tk) gene therapy of malignant gliomas. The purpose of this study was to investigate the brain pharmacokinetics and tumor uptake of GCV in the BT4C rat glioma model. GCV’s brain and tumor uptakes were investigated by in vivo microdialysis in rats with orthotopic BT4C glioma. In addition, the ability of GCV to cross the blood-brain barrier and tumor vasculature was assessed with in situ rat brain perfusion. Finally, the extent to which GCV could permeate across the BT4C glioma cell membrane was assessed in vitro. The areas under the concentration curve of unbound GCV in blood, brain extracellular fluid (ECF), and tumor ECF were 6157, 1658, and 4834 μM⋅min, respectively. The apparent maximum unbound concentrations achieved within 60 minutes were 46.9, 11.8, and 25.8 μM in blood, brain, and tumor, respectively. The unbound GCV concentrations in brain and tumor after in situ rat brain perfusion were 0.41 and 1.39 nmol/g, respectively. The highly polar GCV likely crosses the fenestrated tumor vasculature by paracellular diffusion. Thus, GCV is able to reach the extracellular space around the tumor at higher concentrations than that in healthy brain. However, GCV uptake into BT4C cells at 100 μM was only 2.1 pmol/mg of protein, and no active transporter–mediated disposition of GCV could be detected in vitro. In conclusion, the limited efficacy of HSV-tk/GCV gene therapy may be due to the poor cellular uptake and rapid elimination of GCV.
Agent-Aware Dropout DQN for Safe and Efficient On-line Dialogue Policy Learning

Hand-crafted rules and reinforcement learning (RL) are two popular choices to obtain dialogue policy. The rule-based policy is often reliable within predefined scope but not self-adaptable, whereas RL is evolvable with data but often suffers from a bad initial performance. We employ a companion learning framework to integrate the two approaches for on-line dialogue policy learning, in which a pre-defined rule-based policy acts as a “teacher” and guides a data-driven RL system by giving example actions as well as additional rewards. A novel agent-aware dropout Deep Q-Network (AAD-DQN) is proposed to address the problem of when to consult the teacher and how to learn from the teacher’s experiences. AAD-DQN, as a data-driven student policy, provides (1) two separate experience memories for student and teacher, (2) an uncertainty estimated by dropout to control the timing of consultation and learning. Simulation experiments showed that the proposed approach can significantly improve both safety and efficiency of on-line policy optimization compared to other companion learning approaches as well as supervised pre-training using static dialogue corpus.
A pilot study of a Mediterranean-type diet intervention in female patients with rheumatoid arthritis living in areas of social deprivation in Glasgow

Background: A Mediterranean-type diet rich in fish, fruit and vegetables and low in saturated fats has been associated with health benefits, including improved cardiovascular profile and benefit in RA. Objective: To overcome obstacles to healthy eating by a community-based intervention promoting a Mediterranean-type diet in patients with RA living in socially deprived areas of Glasgow. Methods: 130 female patients with RA aged 30–70 years (median 55), disease duration 8 years were recruited from three hospital sites. The intervention group (n = 75) attended weekly 2-hour sessions for 6 weeks in the local community, including hands-on cooking classes backed up with written information. The control group (n = 55) were given dietary written information only. Both groups completed food frequency questionnaires (FFQs), and clinical and laboratory measures were assessed at baseline, 3 and 6 months. Results: Significant benefit was shown in the intervention group compared with controls for patient global assessment at 6 months (p = 0.002), pain score at 3 and 6 months (p = 0.011 and 0.049), early morning stiffness at 6 months (p = 0.041) and Health Assessment Questionnaire score at 3 months (p = 0.03). Analysis of the FFQs showed significant increases in weekly total fruit, vegetable and legume consumption and improvement in the ratio of monounsaturated:saturated fat intake and systolic BP in the intervention group only. The cooking classes were positively received by patients and tutors; cost/patient for the 6 week course was £84 (€124). Conclusions: Results demonstrate that a 6 week intervention can improve consumption of healthier foods. If implemented more widely it may prove a popular, inexpensive and useful adjunct to other RA treatment.
On the orthogonalization of arbitrary Boolean formulae

The orthogonal conjunctive normal form of a Boolean function is a conjunctive normal form in which any two clauses contain at least a pair of complementary literals. Orthogonal disjunctive normal form is defined similarly. Orthogonalization is the process of transforming the normal form of a Boolean function to orthogonal normal form. The problem is of great relevance in several applications, for example, in the reliability theory. Moreover, such problem is strongly connected with the well-known propositional satisfiability problem. Therefore, important complexity issues are involved. A general procedure for transforming an arbitrary CNF or DNF to an orthogonal one is proposed. Such procedure is tested on randomly generated Boolean formulae.
Delay Minimization in Varying-Bandwidth Direct Multicast with Side Information

We study the delay minimization in a direct multicast communication scheme where a base station wishes to transmit a set of original packets to a group of clients. Each of the clients already has in its cache a subset of the original packets, and requests for all the remaining packets. The base station communicates directly with the clients by broadcasting information to them. Assume that bandwidths vary between the station and different clients. We propose a method to minimize the total delay required for the base station to satisfy requests from all clients.
What about us, seniors? What difficulties do we face using Information and Communication Technology?

In a society marked by rapid demographic ageing and constant technological advances, investing in studies that promote communication and lessen social isolation is justified. This study aims to present the main difficulties seniors face using Information and Communications Technology (ICT), particularly computers; writing and formatting text, accessing the Internet to browse and do research; and using asynchronous and synchronous communication services like email and instant messaging. For conducting this study, partnerships were established with four Private Institutions for Social Solidarity in the municipality of Aveiro, within the scope of the SEDUCE project. The tools used for data collection were two questionnaire surveys and a field journal. The study included the participation of 22 seniors who used ICTs twice a week, in a total of 80 sessions of 90 minutes each. The results suggest that, although seniors experience countless and various difficulties, they are motivated, interested and determined to make the effort of integrating this activity into their daily life.
Lives and deaths : selections from the works of Edwin S. Shneidman

Edwin S. Shneidman is recognized as the central figure in the field of suicidology. His writings have taught countless psychologists and other health professionals about the complexity of suicide, death and bereavement. This collection of his writings spans the entirety of his career and offers a unique insight into the development of his thinking. The material is broken down into five parts: Psychological Assessment, Logic, Melville and Murray, Suicide, and Death and each section includes an introduction by the editor. Lives and Deaths is a vital resource for those in suicidology and related fields, allowing the reader to sample a variety of selections from Shneidman's work in one compact volume. The book is ideal for classroom use by upper level undergraduates and graduate students in the history of suicidology or as a supplemental text in a general suicidology course. It is also of interest to clinicians treating high-risk patients as well as a more general audience including psychologists, social workers, crisis counselors and suicide prevention specialists.
Endovascular Therapy of Symptomatic Intracranial Stenosis in Patients With Impaired Regional Cerebral Blood Flow or Failure of Medical Therapy

BACKGROUND AND PURPOSE:Symptomatic intracranial stenoses have a high risk for a recurrent stroke if treated medically. Although angioplasty and stent placement are proposed treatment options, data on longer-term outcome are limited. Materials and METHODS:We analyzed all endovascular procedures on symptomatic intracranial stenosis at our institution from January 1998 to December 2005. We retrospectively assigned patients to group A (symptoms despite antithrombotic therapy) or group B (impaired regional cerebral blood flow [rCBF]). Primary outcome events were periprocedural major complications or recurrent ischemic strokes in the territory of the treated artery. We used the Kaplan-Meier method to calculate survival probabilities. RESULTS:The procedural technical success rate was 92% (35/38) with periprocedural major complications in 4 cases (10.5%; group A [8.3%, 2/24], group B [14.3%, 2/14]). Median (range) follow-up for the 33 patients with technically successful procedures was 21 (0–72) months. Recurrent ischemic strokes occurred in 15% (3/20) of patients in group A and 0% (0/13) of patients in group B. Overall, there were 21% (7/33) primary outcome events (group A [25%, 5/20], group B [15%, 2/13]). There was a nonsignificant trend for better longer-term survival free of a major complication or recurrent stroke in patients with impaired rCBF compared with patients who were refractory to medical therapy treatment (Kaplan-Meier estimate 0.85 [SE 0.10] vs 0.72 [SE 0.11] at 2 years, respectively). CONCLUSION:Interventional treatment of symptomatic intracranial stenosis carries significant risk for complications and recurrent stroke in high-risk patients. The observation that patients with impaired rCBF may have greater longer-term benefit than medically refractory deserves further study.