Miracle-dz/UniFAR-FTUs huggingface dataset:
Smartphone-Based Psychotherapeutic Micro-Interventions to Improve Mood in a Real-World Setting

Background: Using mobile communication technology as new personalized approach to treat mental disorders or to more generally improve quality of life is highly promising. Knowledge about intervention components that target key psychopathological processes in terms of transdiagnostic psychotherapy approaches is urgently needed. We explored the use of smartphone-based micro-interventions based on psychotherapeutic techniques, guided by short video-clips, to elicit mood changes. Method: As part of a larger neurofeedback study, all subjects—after being randomly assigned to an experimental or control neurofeedback condition—underwent daily smartphone-based micro-interventions for 13 consecutive days. They were free to choose out of provided techniques, including viscerosensory attention, emotional imagery, facial expression, and contemplative repetition. Changes in mood were assessed in real world using the Multidimensional Mood State Questionnaire (scales: good–bad, GB; awake–tired, AT; and calm–nervous, CN). Results: Twenty-seven men participated on at least 11 days and were thus included in the analyses. Altogether, they underwent 335, generally well-tolerated, micro-intervention sessions, with viscerosensory attention (178 sessions, 53.13%) and contemplative repetition (68 sessions, 20.30%) being the most frequently applied techniques. Mixed models indicated that subjects showed better mood [GB: b = 0.464, 95%confidence interval (CI) [0.068, 0.860], t(613.3) = 2.298, p = 0.022] and became more awake [AT: b = 0.514, 95%CI [0.103, 0.925], t(612.4) = 2.456, p = 0.014] and calmer [CN: b = 0.685, 95%CI [0.360, 1.010], t(612.3) = 4.137, p < 0.001] from pre- to post-micro-intervention. These mood improvements from pre- to post-micro-intervention were associated with changes in mood from the 1st day until the last day with regard to GB mood (r = 0.614, 95%CI [0.297, 0.809], p < 0.001), but not AT mood (r = 0.279, 95%CI [−0.122, 0.602], p = 0.167) and CN mood (r = 0.277, 95%CI [0.124, 0.601], p = 0.170). Discussion: Our findings provide evidence for the applicability of smartphone-based micro-interventions eliciting short-term mood changes, based on techniques used in psychotherapeutic approaches, such as mindfulness-based psychotherapy, transcendental meditation, and other contemplative therapies. The results encourage exploring these techniques' capability to improve mood in randomized controlled studies and patients. Smartphone-based micro-interventions are promising to modify mood in real-world settings, complementing other psychotherapeutic interventions, in line with the precision medicine approach. The here presented data were collected within a randomized trial, registered at ClinicalTrials.gov (Identifier: NCT01921088) https://clinicaltrials.gov/ct2/show/NCT01921088.
Distributed message routing and run-time support for message-passing parallel programs derived from ordinary programs

This paper introduces a method for run-time support of'object progt'ams for mul.ticomputers translated from ordinary source programs. This method, Control State Scheduling, allows distributed message routing and control based on information already computed by the program. CSS also supports arbitrary division of the source computation into parallel processes or threads. We describe the method and give some evidence o/ i ts efficiency. d " "' " "• " " "" " K e w a r s " Scheduling, Muhicomputers, Parallelism. I n t r o d u c t i o n . Many methods have been proposed for dividing an ordinary sequential program into pieces which can run in parallel (e.g., [2], [8], [4]). For multicomputers, the object programs consist of some variety of light processes or threads, communicat ing through messages. This paper presents a method for distributed run-t ime control of such object programs called Control State Scheduling. Values of ordinary computat ion variables name processes and direct communicatibns, providing distributed control of process naming and message routing. CSS also supports division of the source program in any way, unlike some other scheduling schemes (e,g., [6], [9]) which schedule individu-al loop iterations as processes. " The method is based.on a the notion of a control state, which is a special subset of the state of the source process. There are three main reasons why this scheme is useful. • Control is distributed there is no need for any global manager of the communications. This.makes it easier for the program to scale to a larger processor. • Control makes use of existing variables. This has the potential to reduce overhead by reducing the amount of overhead computation• * Control State Scheduling supports completely arbitrary division of a sequential computation: This allows an iteration to be divided, and its parts given to different processes. Odd-numbered iterations may be treated differently from even-numbered ones. If s ta tements inside loops may be executed, without having to idle the processors where the if is false. Loops may contain two-branch if 's or case statements. The execution time of iterations Permission to copy without f ~ all or part of this material is granted provided that the copies arc not made or digaibuted for direct commercial advantage, the ACM copyright notice and me rifle of the publication and its date appear, and notice b given that copying is by permission of the Association for Computing Machinery. To copy otherwise, or to republish. , requires a fee and/or specific permission. C 1994 ACM 089791-647.6/94/0003 $3.50 510 sl num := M; s2 sub := N; s3 while hUm ! = 0 do s4 dig := num mad i0; s5 num : = num div I0; s6 arr[sub] := chr(ord('O')+dig); s7 sub := s u b l , s8 od; s9 print (arr, sub+ i) Figure 1: Conversion Example Code. may differ without having to idle processors to synchronize at each iteration.
Cowpea and Groundnut Haulms Fodder Trading and Its Lessons for Multidimensional Cowpea Improvement for Mixed Crop Livestock Systems in West Africa

Cowpea is an important legume crop in Africa, valued highly for its grain and also haulms, which are a tradable commodity in fodder markets. Fodder market surveys in Northern Nigeria showed that groundnut haulms were priced higher than cowpea haulms, probably because of their superior nutritive value. The economic value of haulms has prompted cowpea breeders and livestock nutritionists to explore haulm fodder traits as additional selection and breeding criteria. Fifty cowpea genotypes cultivated across five locations in Nigeria in 2013 and 2014 were evaluated for food fodder traits. Significant (P < 0.05) genotypic dependent variations were observed in yields (kg/ha) of grains (537–1082) and haulms (1173–3368), though significant (P < 0.05) effects of location and year were observed. Grain and fodder yield had a tendency to be positively correlated (r = 0.26, P = 0.07). Haulms were analyzed for nitrogen (N), fiber fractions, in vitro digestibility, and metabolizable energy content. Highly significant variations were observed in all genotypic and livestock nutrition traits, although location and year had significant effects. Trade-offs between grain yield and haulm fodder quality traits were largely absent and haulm acid detergent lignin and grain yield were even inversely correlated (r = -0.28, P = 0.05), that is high grain yielders had decreased haulm lignin. However, haulm N and grain yield also tended to be negatively associated (r = -0.26, P = 0.07). Haulm fodder quality traits and haulm yield were mostly positively correlated (P < 0.05). Broad sense heritabilities for grain and fodder yield were 0.50 and 0.29, respectively, while heritability for haulm fodder quality traits ranged from 0.61 to 0.67, providing opportunities for concomitant increase in grain yield and haulm fodder quality traits. Selection of the 10 highest ranking genotypes for grain yield, haulm yield, haulm N, and haulm in vitro organic matter digestibility showed selection groups overlapping, suggesting that multi-trait selection is feasible. Economical evaluation showed that choice of primary traits is context specific, highlighting the need for identifying and targeting appropriate genotypes to fit different production systems. Considering haulm quantity and quality as traits of economic value can increase overall plant value in mixed crop-livestock systems.
Objective measurements of voice treatment efficacy for voice-disordered patients

Abstract The purpose of this study is to investigate a set of objective measurements with high reliability and validity in quantifying voice treatment efficacy. Thirty female voicedisordered patients in the ENT Department received perceptual judgement, videostroboscopy, acoustic analysis and aerodynamic analysis before and after voice treatment. Paired t-test and Spearman rank correlation were performed to analyse test–retest and intra- as well as inter-subject reliability, the strength of linear relationship between subjective and objective measures, and clinical significance of voice treatment. Test–retest and intra- as well as inter-subject reliability for most of the objective measures and all subjective measures is 0.9. Most objective measures show a significant correlation to subjective measures. Acoustic and aerodynamic measures of HIN, H1-H2, number of harmonics, speaking F0, speaking intensity, physiological frequency range, physiological intensity range, maximum phonation time and intraoral pressure have high and equal sensitivity and specificity to perceptual judgement and videostroboscopic measures. Most of the objective measures in this study can significantly quantify voice treatment efficacy. Further research across different age groups in females is needed to verify the results.
Selection of Shared and Neoantigen-Reactive T Cells for Adoptive Cell Therapy Based on CD137 Separation

Adoptive cell therapy (ACT) of autologous tumor infiltrating lymphocytes (TIL) is an effective immunotherapy for patients with solid tumors, yielding objective response rates of around 40% in refractory patients with metastatic melanoma. Most clinical centers utilize bulk, randomly isolated TIL from the tumor tissue for ex vivo expansion and infusion. Only a minor fraction of the administered T cells recognizes tumor antigens, such as shared and mutation-derived neoantigens, and consequently eliminates the tumor. Thus, there are many ongoing effects to identify and select tumor-specific TIL for therapy; however, those approaches are very costly and require months, which is unreasonable for most metastatic patients. CD137 (4-1BB) has been identified as a co-stimulatory marker, which is induced upon the specific interaction of T cells with their target cell. Therefore, CD137 can be a useful biomarker and an important tool for the selection of tumor-reactive T cells. Here, we developed and validated a simple and time efficient method for the selection of CD137-expressing T cells for therapy based on magnetic bead separation. CD137 selection was performed with clinical grade compliant reagents, and TIL were expanded in a large-scale manner to meet cell numbers required for the patient setting in a GMP facility. For the first time, the methodology was designed to comply with both clinical needs and limitations, and its feasibility was assessed. CD137-selected TIL demonstrated significantly increased antitumor reactivity and were enriched for T cells recognizing neoantigens as well as shared tumor antigens. CD137-based selection enabled the enrichment of tumor-reactive T cells without the necessity of knowing the epitope specificity or the antigen type. The direct implementation of the CD137 separation method to the cell production of TIL may provide a simple way to improve the clinical efficiency of TIL ACT.
Increasing capacity for skin surveillance in a transplant review clinic.

ow naded rom http:urnals.lw w om /transtjournalby hD M fePH bH 4TIm qVAH xkFJpPk1L/H vM G w qM xG jw O deJPG +b4D lKuA44qu/vw zm c= on 079/2018 Downloadedfromhttp://journals.lww. com/transplantjournalbyBhDMf5ePHKbH4TTImqenVAHxkFJp/XpPk1L/H3vMGwqMxG9jwOd8eJPG+b4DlKuAX44qu/vwzmc=on07/29/2018 virus-negative at 2 weeks into this regimen and remained negative 12 weeks after completing all therapy (SVR 12). Daclatasvir, an NS5A inhibitor, is pan-genotypic and when combined with other DAAs has demonstrated very high SVR rates in difficult-to-treat patients infected with genotype 1b who are previous null responders to PEG-IFN and ribavirin (4). In addition, daclatasvir in combination with sofosbuvir, an NS5B inhibitor, has shown very promising results in treatment-naive genotype 1a, 1b, 2, and 3 infected patients as well as in genotype 1 patients who have failed therapy with boceprevir or telaprevir (5). Although the patient had a robust response to triple therapy, he continued to be HCV RNA detectable and thus was deemed a failure to boceprevir-based therapy and, in addition, he had several adverse events. Furthermore, because of drug-drug interactions caused by boceprevir, dose adjustments were required for the calcineurin inhibitor, tacrolimus. Daclatasvir in combination with PEG-IFN and ribavirin has already been successfully used in a liver transplant recipient who had not been exposed to a protease inhibitor (6). Daclatasvir has also been used in combination with sofosbuvir in a single case of cholestatic hepatitis C post-LT (7). However, this is the first case of successful treatment of hepatitis C with daclatasvir, PEG-IFN, and ribavirin after failure with a PI in an LT recipient. It is likely that the initial boceprevir-based therapy failed as a result of the patient being intolerant of the regimen. Largely, daclatasvir was effective because the patient demonstrated interferon responsiveness while on boceprevir. Although there were challenges of adverse events with interferonbased therapy, we opted not to treat the patient with only DAAs because of the high rate of viral resistance to these drugs without the backbone of pegylated interferon and ribavirin (8Y10). In this case, daclatasvir allowed PEGIFN and ribavirin to be administered at appropriate (although reduced) doses and without drug-drug interactions. While all-oral therapy with DAAs is desirable in these patients, it may not be pragmatic for reasons of cost and global availability. Therefore, daclatasvir may present an opportunity to treat the chalenging population of LT recipients, along with PEG-IFN and ribavirin, particularly in those who may have failed PI-based therapy. K. Rajender Reddy, MD Amina Wirjosemito, MPH Tanya M. Pavri, BA Lorie Sinese, PA-C 1 Division of Gastroenterology and Hepatology, Perelman School of Medicine at the University of Pennsylvania Philadelphia, PA
EFFECT OF GROWTH FACTOR-FIBRONECTIN MATRIX INTERACTION ON RAT TYPE II CELL ADHESION AND DNA SYNTHESIS

Type II cells attach, migrate, and proliferate on a provisional fibronectin-rich matrix during alveolar wall repair after lung injury. The combination of cell-substratum interactions via integrin receptors and exposure to local growth factors are likely to initiate the signals required for cell proliferation, differentiation, reepithelialization, and ultimate restoration of the alveolar wall structure. Accordingly, primary cultured type II cells have been shown to bind fibronectin, in part through the α 5 β 1 integrin, and to respond to growth factors that induce type II cell proliferation, such as fibroblast growth factor 1 (FGF-1). The purpose of this study was to determine whether or not FGF-1 modifies type II cell attachment to fibronectin, and if together they affect DNA synthesis. Attachment assays showed that FGF-1 treatment enhanced type II cell adhesion to fibronectin. This effect correlated with an increase in β 1 integrin cell surface expression, and with the formation of cytoskeletal stabilizing structures such as lamellipodial extensions and stress fibers. FGF-1 also induced an increase in thymidine in corporation into DNA. Together FGF-1 and fibronectin appear to promote adhesion, cytoskeletal organization, and in creased DNA synthesis, and in this way influence cell-substratum interactions and signaling during alveolar repair.
Gray Computing: An Analysis of Computing with Background JavaScript Tasks

Websites routinely distribute small amounts of work to visitors' browsers in order to validate forms, render animations, and perform other computations. This paper examines the feasibility, cost effectiveness, and approaches for increasing the workloads offloaded to web visitors' browsers in order to turn them into a large-scale distributed data processing engine, which we term gray computing. Past research has looked primarily at either non-browser based volunteer computing or browser-based volunteer computing where the visitors keep their browsers open to a single web page for a long period of time. This paper provides a deep analysis of the architectural, cost effectiveness, user experience, performance, security, and other issues of gray computing distributed data processing engines with high heterogeneity, non-uniform page view times, and high computing pool volatility.
Mother–child interaction and sleep regulation in one‐year‐olds

La regulation des etats de sommeil-reveil est non seulement controlee par des mecanismes biologiques mais aussi par le contexte de mode de soin. Dans cette etude l'association entre la relation mere-enfant et le sommeil du bebe a ete examinee. Trente-sept bebes de 12 mois et leurs meres participerent a un episode de jeu de 10 minutes en laboratoire. L'interaction dyadique fut codee avec l'Evaluation de la Relation Parent-Enfant (Early Parent-Child Relational Assessment, en anglais, Clark, 1985) et avec les echelles de Disponibilite Emotionnelle (Biringen, Robinson, & Emde, 1993). Le sommeil de l'enfant fut mesure a domicile avec un petit moniteur informatise. Alors que le comportement des meres n'etait pas lie au sommeil de l'enfant, les bebes reagissant le mieux durant l'episode de jeu se reveillaient plus frequemment que les bebes qui prenant moins part a l'interaction. Le lien entre la competence sociale-emotionnelle et le sommeil fragmente, chez les bebes n'etant pas a risque pourrait etre un phenomene lie a l'âge.
RS Ophiuchi: thermonuclear explosion or disc instability?

Sokoloski, Rupen & Mioduszewski have recently reported evidence that the recurrent nova RS Ophiuchi produced a pair of highly collimated radio jets within days of its 2006 outburst. This suggests that an accretion disc must be present during the outburst. However, in the standard picture of recurrent novae as thermonuclear events, any such disc must be expelled from the white dwarf vicinity, as the nuclear energy yield greatly exceeds its binding energy. We suggest instead that the outbursts of RS Oph are thermal-viscous instabilities in a disc irradiated by the central accreting white dwarf. The distinctive feature of RS Oph is the very large size of its accretion disc. Given this, it fits naturally into a consistent picture of systems with unstable accretion discs. This picture explains the presence and speed of the jets, the brightness and duration of the outburst, and its rise time and linear decay, as well as the faintness of the quiescence. By contrast, the hitherto standard picture of recurrent thermonuclear explosions has a number of severe difficulties. These include the presence of jets, the faintness of quiescence, and the fact the accretion disc must be unstable unless it is far smaller than any reasonable estimate.
Using a Uniform-Weight Grammar to Model Disfluencies in Stuttered Read Speech : A Pilot Study

Stuttering is a speech disorder characterized by certain types of speech disfluencies, such as sound repetitions, which are frequent enough to be disruptive. Speech therapists frequently use manual counts of these speech disfluencies to diagnose whether a child stutters and to track improvement through a treatment program. However, these counts are subjective, inconsistent, and prone to error. We propose the use of speech recognition technology to automate these counts, thus providing an objective and consistent measurement. Since many of the disfluencies in stuttered speech obey certain regularities, we built several grammar-based language models that capture these regularities to detect disfluencies. These grammars have uniform transition weights. We tested the grammars on a short sample of stuttered speech and analyzed their performance based on word error rate and how well they detect and classify disfluencies. Results indicate that these grammars detect repetition disfluencies poorly, particularly phoneme repetitions. We are currently building a probabilistic language model and expect that the more accurate transition probabilities will lead to a decrease in false positives. We also expect that further improvement will be achieved by modeling the acoustic properties of stuttered speech.
Urinary Output Predicts Survival in Patients Undergoing Extracorporeal Membrane Oxygenation Following Cardiovascular Surgery

Objectives:Extracorporeal membrane oxygenation represents a valuable and rapidly evolving therapeutic option in patients with severe heart or lung failure following cardiovascular surgery. However, survival remains poor and accurate risk stratification challenging. Therefore, we evaluated the predictive value of urinary output within 24 hours after extracorporeal membrane oxygenation initiation on mortality in patients undergoing venoarterial extracorporeal membrane oxygenation support following cardiovascular surgery and aimed to improve established risk prediction models. Design:Single-center, observational registry. Setting:University-affiliated tertiary care center. Patients:We included 205 patients undergoing veno-arterial extracorporeal membrane oxygenation therapy following cardiovascular surgery at a university-affiliated tertiary-care center into our single-centre registry. Interventions:None. Measurements and Main Results:During a median follow-up time of 35 months (interquartile range, 19–69), 64% of patients died. Twenty-four–hour urinary output was the strongest predictor of outcome among renal function variables with an adjusted hazard ratio per 1 SD of 0.55 (95% CI, 0.40–0.76; p < 0.001) for 30-day mortality and of 0.65 (95% CI, 0.53–0.86; p = 0.002) for 2-year long-term mortality. Most remarkably, 24-hour urinary output showed additional prognostic value beyond that achievable with the simplified acute physiology score-3 and sequential organ failure assessment score indicated by improvements in the category-free net reclassification index for 30-day mortality (simplified acute physiology score-3: 36%, p = 0.015; sequential organ failure assessment score: 36%, p = 0.02), as well as for 2-year mortality (simplified acute physiology score-3: 33%, p = 0.02; sequential organ failure assessment score: 43%, p = 0.005). Conclusions:We identified 24-hour urinary output as a strong and easily available predictor of mortality in patients undergoing extracorporeal membrane oxygenation therapy following cardiovascular surgery. Implementation of 24-hour urinary output leads to a substantial improvement of established risk prediction models in this vulnerable patient population. These results are particularly compelling because measurement of urinary output is inexpensive and routinely performed in all critical care units.