Miracle-dz/UniFAR-FTUs huggingface dataset:
The involvement of osteopontin and its receptors in multiple myeloma cell survival, migration and invasion in the murine 5T33MM model

Multiple myeloma (MM) is a malignancy characterised by the accumulation of monoclonal plasma cells in the bone marrow. Different reports indicate the expression of CD44 variant isoforms (CD44v) by MM cells. Osteopontin (OPN), which is expressed by MM cells, is known to be a ligand for CD44v6. In this study, we investigated the role of OPN with emphasis on a functional correlation between OPN and CD44v in the 5T33MM model. Our group reported the expression of CD44v by 5T33MM cells. Using this model, we have demonstrated the secretion of OPN by 5T33MM cells. OPN affected 5T33MM cell survival by increasing proliferation and inhibiting apoptosis. OPN also stimulated 5T33MM cell migration, transendothelial migration and matrix metalloproteinase‐9 activity. We confirmed the proliferative and migratory effects of OPN on human MM cells. By applying inhibiting anti‐CD44v6 antibodies, we found that OPN stimulated cell proliferation by engaging this isoform. Anti‐CD44v antibodies and RGD peptides both inhibited cell migration, suggesting an involvement of both, CD44v isoforms and integrins. In conclusion, OPN may act as a mediator of MM cell survival by engaging CD44v. The protein is further involved in migration and invasion of MM cells through the activation of either αvβ3 integrin or CD44v isoforms.
Organization of the efferent projections of the nucleus accumbens to pallidal, hypothalamic, and mesencephalic structures: A tracing and immunohistochemical study in the cat

The efferent connections of the nucleus accumbens in the cat were studied with the aid of anterograde and retrograde tracing techniques. The description of the topography of these projections to pallidal, hypothalamic, and mesencephalic areas is preceded by a redefinition of the borders of the pallidal regions in the cat, using immunohistochemical criteria. In agreement with previous studies in rat and monkey substance‐P‐like and enkephalinlike immunoreactivity in the pallidum of the cat appears to be present in so‐called “woolly fibers. ” Substance‐P‐ and enkephalin‐positive woolly fibers are differentially distributed in the internal and external segments of the globus pallidus, as traditionally defined, but are both present in the rostral part of the substantia innominata, here called the “ventral pallidum. ” Woolly fibers are also found in a number of other basal telencephalic structures and in the rostral part of the lateral hypothalamic area.
The use of a synthetic skin substitute as a physical barrier to enhance healing in human periodontal furcation defects: a follow-up report.

The purpose of this investigation is to compare the clinical response of guided tissue regeneration using a synthetic wound dressing with open flap debridement versus open flap debridement alone in the treatment of human furcation defects. The study group was composed of 19 patients with moderate to advanced adult periodontitis and at least one bilateral pair of Class II molar furcation defects. After the hygiene phase of therapy was completed, measurements were made with calibrated periodontal probes of the clinical attachment levels, probing depths, and soft tissue recession. Paired sites were randomly selected for treatment with either open flap debridement alone (control) or open flap debridement and placement of the synthetic wound dressing over the furcation (experimental). At the time of surgery, measurements of vertical and horizontal open probing attachment were recorded. The dressing was removed 5 to 6 weeks post-surgery. The sites were reentered at 6 months to evaluate healing and to repeat all measurements. Statistical comparisons using the Wilcoxon Sign Rank Test were made between the control and experimental sites. The results of 19 pairs of Class II molar furcation defects reveal statistically significant differences between the experimental and control sites in attachment levels, probing depths, and horizontal open probing attachment. These differences were of such small magnitude that they may not be clinically relevant. There were no other significant differences for any other clinical parameter, and none of the furcations in either group was completely closed. (ABSTRACT TRUNCATED AT 250 WORDS)
Channel estimation technique for mitigating ICI in MIMO-OFDM cellular systems

Maximum-likelihood (ML) channel estimation for multiple-input-multiple-output (MIMO) channels is derived when orthogonal frequency division multiplexing (OFDM) is employed in cellular systems. While conventional single-cell ML estimation (SCMLE) disregards the effects of inter-cell interference (ICI), multi-cell ML estimation (MCMLE) exploits the knowledge of the preambles from neighboring base stations (BSs) to combat severe ICI. The mean square error (MSE) of the MCMLE is smaller than the conventional SCMLE at the cell boundaries where signal-to-interference ratio (SIR) is about 0 dB. However, the MCMLE performs worse than the SCMLE when the mobile station (MS) is near BS because the MCMLE estimates more parameters than the SCMLE. In addition, we evaluate the influence of non-ideal preambles to the performance of channel estimation because all the preambles in cells cannot be mutually orthogonal in practice. Numerical results confirm the superiority of the MCMLE to the SCMLE when SIR has a range of 0/spl sim/15 dB.
Public Education Spending and GDP in China: Granger Causality Tests Using Toda-Yamamoto Technique

The quantity of national fiscal budget expenditure on education in China has expanded over the past decade. The paper aims to investigate whether GDP may be a significant cause of public education spending. Three series covered the period from 1991-2011. The paper utilized an unconventional Granger causality test in order to deal with the integrated properties of data. Both GDP and CPI Granger caused the share of public education spending to GDP. GDP expansion has contributed significantly to public education spending at least in the short term Index Terms Fiscal budget expenditure, education, economic growth, Granger causality, Toda-Yamamoto test
Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells

Adhesion between neighbouring epithelial cells is a crucial and tightly controlled process. In the gastrointestinal tract, the integrity of cell-cell contacts is essential for the regulation of electrolyte absorption and for the prevention of tumour metastasis. We recently showed that migration of the gastric epithelial cell line IMGE-5 is stimulated by the nonamidated form of the hormone gastrin17. Here, we examine the effect on cell-cell adhesion of the prohormone progastrin, the concentration of which is increased in the plasma of patients with colorectal carcinoma. Progastrin induced the dissociation of both tight junction (TJ) and adherens junction (AJ) complexes in IMGE-5 cells. In progastrin-secreting DLD-1 human colorectal carcinoma cells, expression of an antisense gastrin construct restored membrane localisation of zonula occludens-1 (ZO-1), occludin, β-catenin and E-cadherin. This restoration was reversed by treatment with exogenous progastrin. Endogenous or exogenous progastrin also increased the paracellular flux of mannitol, and induced cell migration of several gastrointestinal cell lines. In addition, progastrin enhanced Src tyrosine kinase activity and induced a spatial delocalisation of protein kinase Cα. Using dominant-negative mutants and pharmacological inhibitors, we showed that the stimulation of Src kinase activity was essential for the regulation of TJs. By contrast, the dissociation of AJs involved phosphatidylinositol 3-kinase, partly through the formation of a complex with protein kinase Cα. We conclude that separate pathways mediate the disruption of AJs and TJs by progastrin. Either pathway may contribute to the co-carcinogenic role of this prohormone in colorectal carcinoma.
Limitations of perceptual segmentation on contextual cueing in visual search

In visual search, detection of a target in a repeated layout is faster than search within a novel arrangement, demonstrating that contextual invariances can implicitly guide attention to the target location (“contextual cueing”; Chun & Jiang, 1998). Here, we investigated how display segmentation processes influence contextual cueing. Seven experiments showed that grouping by colour and by size can considerably reduce contextual cueing. However, selectively attending to a relevant subgroup of items (that contains the target) preserved context-based learning effects. Finally, the reduction of contextual cueing by means of grouping affected both the latent learning and the recall of display layouts. In sum, all experiments show an influence of grouping on contextual cueing. This influence is larger for variations of spatial (as compared to surface) features and is consistent with the view that learning of contextual relations critically interferes with processes that segment a display into segregated groups of items.
The nature and use of bereavement support services in a hospice setting

This study formed part of a larger project designed to evaluate a hospice-based bereavement support service in Ireland. It involved a detailed assessment of the views of service attenders and non-attenders. A postal survey was administered to all bereaved clients who were invited to one or more bereavement support services (n = 517). Respondents (n = 243; 47%) completed: 1) a Bereavement Services Questionnaire; 2) a measure of grief reaction (TRIG) and 3) a measure of religiosity (SCSORF). A total of 243 people (47%) returned completed questionnaires, most of whom were satisfied with the service, (although not all had attended all elements of the bereavement service). However, a number of improvements were emphasised. Several statistically significant differences (P < 0.05) also emerged between service attenders and non-attenders with respect to grief reaction and other key factors (e.g., the age and relationship to the deceased). The findings emphasise the needs and views of both attenders and non-attenders and provide important lessons for the implementation and development of hospice-based bereavement support services.
Investigation of a new motor assessment scale for stroke patients.

The purpose of this paper is to present and describe a motor assessment scale (MAS) for stroke patients and to report on the investigation of two aspects of its reliability. The MAS is a brief and easily administered assessment of eight areas of motor function and one item related to muscle tone. Each item is scored on a scale from 0 to 6. To check interrater reliability, we videotaped five stroke patients while they were being assessed with the MAS. These scores were used as the criterion ratings. Twenty raters then assessed these patients, and their results were correlated with the criterion ratings. We determined test-retest reliability by assessing on two occasions, separated by a four-week interval, 14 stroke patients whose recovery was considered to be stable and by correlating these scores. The MAS was found to be highly reliable with an average interrater correlation of . 95 and an average test-retest correlation of . 98.
GRIEF COMMUNICATION, GRIEF REACTIONS AND MARITAL SATISFACTION IN BEREAVED PARENTS

This study examined if attitudes about grief communication are related to grief reactions and marital satisfaction in bereaved parents. The sample consisted of 36 couples who experienced the loss of a child. For the couple as a unit, the relation between attitudes about communication and grief changed over time, and the nature of the change was related to the level of communication; positive attitudes about open communication were related to high grief in the early stages of bereavement and to low grief in later stages. No relation to marital satisfaction was found. Spouses were correlated in their attitudes about communication, but women valued open communication significantly more than men. Positive attitudes about grief communication were related to men's grief reactions but not marital satisfaction; whereas for women, positive attitudes were related to marital satisfaction but not grief.
Effects of Thalidomide Combined with Interferon on Inhibiting Kasumi-1 Cell Proliferation.

BACKGROUND Our previous clinical observations proved that the combination of thalidomide and interferon (IFN) had certain effects in relapsed or refractory AML. OBJECTIVES The aim of this study was to investigate the effects and its mechanism of thalidomide and IFN on inhibiting the proliferation of Kasumi-1 cells. MATERIAL AND METHODS Thalidomide, IFN and a combination of both drugs were used to treat Kasumi-1 cells. The inhibition of cell proliferation and the apoptosis rate were measured. Vascular endothelial growth factor levels and the expression of apoptosis-related proteins were detected by ELISA and Western blotting, respectively. RESULTS Thalidomide and IFN could both inhibit Kasumi-1 cell proliferation in a dose-dependent manner. When Kasumi-1 cells were treated with thalidomide 350 μg/mL or IFN1400 U/mL for 48 h, the proliferation inhibition rates were (48.8 ± 4.64)% and (50.19 ± 2.59)% and the rates of apoptosis were (14.68 ± 2.61)% and (21.71 ± 0.71)%, respectively; when treated with a combination, the cell proliferation inhibition rate and apoptotic rate were statistically significantly higher than both the control group and the groups treated with a single drug. The ELISA assay revealed that both 350 μg/mL of thalidomide and 1400 U/mL of IFN could reduce the VEGF levels in cell culture supernatants; the two-drug combination group had a further decreased VEGF concentration. Forty-eighthour treatment of thalidomide 350 μg/mL and IFN 1400 U/mL could significantly decrease Bcl-2 expression and increase the expression levels of phosphor-P38, BAX, cytochrome c, and cleaved caspase-3, -8, and -9 as compared to the control group. The combination group exhibited significantly greater extents of reduction in Bcl-2 protein and increases in p-P38, BAX, and cytochrome c, and cleaved caspase-3, -8, and -9 protein expression as compared to the single drug groups. CONCLUSIONS Thalidomide and IFN can synergistically inhibit Kasumi-1 cell proliferation, which is possibly achieved through the mitochondrial and death receptor pathways and through the activation of the P38 signaling pathway to induce apoptosis and by inhibiting Kasumi-1 cell autocrine VEGF secretion.
Cloud Computing: A Silver Lining in the Dark Clouds of Crisis Management of Economic Slowdown

Industries, by and large, devise various ways and means to reduce the cost of production/services to offer cheaper goods/services to the customers: IT industry is no exception to this. The R&D units of the IT industry are burning their midnight oil to reduce their investment in infrastructure, engaging of IT professionals and the recurring expenditure. The concept of ‘Cloud Computing’ originated in the recent past has become handy to reduce the cost. In due course ‘Cloud Computing’ will be another popular utility service such as electricity, telephony, water supply etc. In this paper, the elements of ‘Cloud Computing’, configuration and advantages are discussed. How cost could be reduced is explained with illustrations. Further, the pitfalls/limitations in ‘Cloud Computing’ are also outlined.
Two phase non-overlapping clock adiabatic differential cascode voltage switch logic (ADCVSL)

Adiabatic digital circuits have the ability to recover energy once committed in computation and make it available for recycling. However, although asymptotically zero energy per computation can be achieved using adiabatic circuits, there are two general issues preventing adiabatic system implementations from outperforming conventional CMOS designs in terms of energy efficiency. First, resonant circuits that provide a clock shaped power supply required by adiabatic circuits and exhibit negligible internal dissipation, are difficult to achieve. The problem is aggravated by the fact that most proposed adiabatic circuit families require multiple-phase clocking. The second issue is related to the design of sequential adiabatic logic circuits which typically trap charge in their internal nodes making a relatively large fraction of delivered energy unavailable for recovery. Adiabatic differential cascode voltage switch logic (ADCVSL) addresses both these issues.
Classifying restaurants to improve usability of restaurant research

Purpose This paper aims to review existing restaurant classifications within the literature in the restaurant management field. The authors discuss intra-industry ramifications of the limited use of recognized typologies and the need to prescriptively guide the description of restaurant context in the literature to communicate the internal and external validity of findings. Design/methodology/approach Restaurant categories from accepted typologies are used as keywords to collect 345 empirical studies from ten relevant journals serving the global restaurant management discipline. Content analysis of titles, abstracts and methodology sections is used to examine three propositions regarding the standardization, rationalization and efficiency of restaurant classification in imparting restaurant context in published works. Findings Findings show inconsistent use of existing typologies and limited use of effective restaurant descriptors to inform users about the situational context in which data were gathered or hypotheses were tested. There is a general preference for categories commonly associated with those of the National Restaurant Association. Research limitations/implications Researchers should standardize descriptions of restaurants in manuscript titles, abstracts and methods sections, thereby enhancing integration of international research, the ability to conduct macro-level industry studies, and communication of findings to practitioners for operational use. Originality/value Recommendations are offered to optimize the use of restaurant classification so that the content of empirical studies may be more effectively accessed, digested and compared, thereby enhancing the communication of advances in the restaurant management body of knowledge to practitioners and other researchers.
Transcranial magnetic stimulation in sport science: A commentary

Abstract The aim of this commentary is to provide a brief overview of transcranial magnetic stimulation (TMS) and highlight how this technique can be used to investigate the acute and chronic responses of the central nervous system to exercise. We characterise the neuromuscular responses to TMS and discuss how these measures can be used to investigate the mechanisms of fatigue in response to locomotor exercise. We also discuss how TMS might be used to study the corticospinal adaptations to resistance exercise training, with particular emphasis on the responses to shortening/lengthening contractions and contralateral training. The limited data to date suggest that TMS is a valuable technique for exploring the mechanisms of central fatigue and neural adaptation.
Implementation of Power Efficient Vedic Multiplier S . S

In this Paper, Urdhva tiryakbhyam Sutra is first applied to the binary number system and is used to develop digital multiplier architecture. This is shown to be very similar to the popular array multiplier architecture. This Sutra also shows the effectiveness of to reduce the NXN multiplier structure into an efficient 4X4 multiplier structures. Nikhilam Sutra is then discussed and is shown to be much more efficient in the multiplication of large numbers as it reduces the multiplication of two large numbers to that of two smaller ones. The proposed multiplication algorithm is then illustrated to show its computational efficiency by taking an example of reducing a 4X4-bit multiplication to a single 2X2-bit multiplication operation. This work presents a systematic design methodology for fast and area efficient digit multiplier based on Vedic mathematics . The Multiplier Architecture is based on the Vertical and Crosswise algorithm of ancient Indian Vedic Mathematics.
An Empirical Analysis on Relationships of Manufacturing Practices and Manufacturing Capabilities

This paper, based on resource-based view, defines that manufacturing capability is the combination of knowledge, skills and implementation of business strategy in manufacturing process. With the adoption of the database IMSS 2003, the empirical study investigates how different practices improve what kind of manufacturing capability and surveys its differences between China and Germany, which meets the requirements of development of Chinese manufacturing enterprises
Abnormal head movement in a patient with tuberculous meningitis

The bobble-head doll syndrome is characterised by abnormal head movements. These head movements are usually ‘yes–yes’ (up and down) type; rarely, head movements are ‘no–no’ (side-to-side) type. Commonly described causes of the bobble-head doll syndrome include third ventricular tumours, suprasellar arachnoid cysts, aqueductal stenosis and other lesions in the region of the third ventricle of the brain. We report a case of tuberculous meningitis with hydrocephalus; in this patient bobble-head doll syndrome developed following external ventricular drainage. In our patient, placement of intraventricular drain led to massive dilatation of the frontal horn of the left lateral ventricle because of blocked foramina of Monro on the left side. The bobble-head doll syndrome, presumably, developed because of the pressure effect of the dilated third ventricle on the dorsomedial nucleus of the thalamus, red nucleus and dentatorubrothalamic pathways. We think that distortion of the third ventricle was responsible for the impairment of the functions of all these structures.
Hidden anvil fracture of the seventh cervical vertebral body.

lar, infiltrating endometrial lesion situated opposite the mesenteric border of the sigmoid, the lumen of which was almost completely occluded. Eggers23 reported three resections, and an instance in which bilateral oophorectomy was the treatment of choice. Patton and Patton"6 performed a colostomy, followed later by a bilateral salpingo-oophorectomy, a resection of the diseased segment of the bowel and an end-to-end anastomosis. Surgically treated cases have also been reported by Bartlett,24 Okinczyc,25 Schofield and Bacon,26 and Papin.7 Surgery and x-ray therapy are safe and effective forms of conservative treatment. Both may be necessary in a given case. Neither the ulceration of the mucosa nor the irradiation effected permanent changes in our case.
Stop-band improvement of rectangular waveguide filters using different width resonators: selection of resonator widths

Rectangular waveguide resonators having different widths can be mixed in order to improve the stopband performance of band-pass filters. Two effective procedures for the choice of the resonator widths are presented and implemented to realise X-band 6-cavity filters which hold 30 dB of attenuation over a frequency range 40% wider than a standard filter. Theoretical and experimental results are shown and commented on.