Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Blepharis maderaspatensis and Ammannia baccifera plant extracts on in vitro oxygen radical scavenging, secretion of gastric fluid and gastroprotection on ulcer induced rats

Context: Blepharis maderaspatensis L. Roth (BM) (Acanthaceae) and Ammannia baccifera L. (AB) (Lythraceae) are used in folk medicine for various stomach disorders. Objective: The chloroform and ethanol extracts of both plants were evaluated for antioxidant, gastric antisecretory, and gastroprotective properties. Methods: Antioxidant properties of the extracts were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and nitric oxide (NO) scavenging assay. The gastric antisecretory properties of the extracts were assessed, at a dose of 100 and 200 mg/kg, using aspirin-pylorus ligation induced gastric ulcer models and the gastroprotective activity of the extracts was assessed, at a dose of 100 and 200 mg/kg, using HCl-ethanol induced ulcer models in rats. Results and discussion: Ethanol extract of BM (EBM) possessed good antioxidant property with IC50 values of 37.4 and 44.1 µg/mL in DPPH and NO scavenging assays respectively, where 25–250 µg/mL concentration in DPPH assay and 30–300 µg/mL concentration in NO scavenging assay were used. Ethanol extract of AB (EAB) at a dose of 200 mg/kg reduced the free acidity to 142.66 mEq/L and total acidity to 451.22 mEq/l. It reduced the gastric secretion with increase in pH from 2.2 to 3.15. Possessing good antisecretory activity, it also reduced the ulcer by 92.2% in aspirin and pylorus ligation induced gastric ulcer models. EAB increased the mucus secretion and adherent mucus in the tissues with a 71.43% reduction of ulcerin HCl-ethanol induced ulcer models, at a dose of 200 mg/kg. This activity can be attributed to the various flavonoids like rutin and kaempferol-3-O-β-glucopyranoside, and the phytosterol, β-sitosterol-3-O-β-glucopyranoside, and phenolics present in the extracts. Conclusion: EBM possessed significant antioxidant property while EAB possessed good antisecretory and gastroprotective activity.
The Effect of Monoclonal Anti-human-platelet Antibodies on Platelet Kinetics in a Baboon Model: IgG Subclass Dependency

Summary We assessed the in vivo effect of six intact anti-human antiplatelet antibodies of two major IgG subclasses on platelet kinetics in baboons. Five of the six antibodies tested caused thrombocytopenia of varying degree when injected at a precalculated threshold value. An agglutinating IgG1 antibody (MA-8L4A12) caused a long-lasting, mild thrombocytopenia with a predominant uptake of radiolabelled platelets in the spleen, while the four IgG2 antibodies tested (MA-13G8E1, MA-2M5A6, MA-21K2E8 and MA-22M10) caused a severe, transient thrombocytopenia with uptake of platelets in the liver. Two of the IgG2 antibodies (MA-13G8E1 and MA-2M5A6) caused platelet activation and aggregation in vitro, whilst the other two did not elicit a platelet aggregation response. The platelet survival time was shortened with all five of the thrombocytopenia-inducing antibodies, while only one antibody (MA-2M5A6) had a significant effect on the bleeding time. This study indicates that the IgG subclasss may be a determining factor in the outcome of platelet sequestration in immune-induced thrombocytopenia.
Energy-saving effects of super computers by using on-site solar power and direct HVDC feeding systems

Power consumption of the ICT sector of information and communication facilities and data centers has grown, and this has led to a need to improve energy efficiency of these facilities. DC distribution systems employing 380 VDC as the supply voltage is one promising approach to address this problem, countries around the world and are progressing to develop and deploy commercial services. We demonstrated a 380 VDC power distribution system interconnected with a solar power generation system. This demonstration showed that the 380 VDC power supply system saves more energy than the AC power supply system and showed how carbon dioxide emissions are reduced by integrating the solar power generation system.
Characterization and evaluation of Aspergillus oryzae lactase coupled to a regenerable support

A derivative of crosslinked Sepharose, p‐(N‐acetyl‐L‐tyrosine azo) benzamidoethyl‐CL‐Sepharose 4B, was synthesized and used for the selective immobilization of thermostable lactase from Aspergillus oryzae.Preparations of soluble and immobilized lactase were evaluated under initial velocity conditions in a batch process. Immobilization had no significant effect on the pH optimum at 50°C or kinetic parameters at pH 4.5 or pH 6.5 and 50°C. At pH 4.5, the soluble enzyme possessed maximum activity at 60°C and the immobilized at 55°C; at pH 6.5 both showed maximum activity at 55°C. The activation energy, entropy, and enthalpy decreased significantly with immobilization at pH 4.5 but not at pH 6.5. When the immobilized enzyme was placed in a packed‐bed reactor, the effect of temperature on activity was altered as reflected by a marked decrease in the thermodynamic parameters of activation at both pH levels. Upon immobilization there was also a dramatic increase in the apparent thermal stability of the lactase, and the mean half‐life at 50°C was increased from 7.2 to 13 days at pH 4.5 and from 3.8 to 16 days at pH 6.5.
Resection of the Inferior Vena Cava for Hepatic Malignancy

Involvement of the inferior vena cava (IVC) by hepatic tumors, although uncommon, is considered to be unresectable by standard surgical techniques. Recent advances in hepatic surgery have made combined hepatic and vena caval resection possible. The purpose of this study is to describe the surgical techniques and early results of combined resection of the liver and IVC. From 1997 to 2000, 11 patients underwent resection of the IVC along with four to seven liver segments. Resections were carried out for hepatocellular carcinoma (four); colorectal metastases (four); and hepatoblastoma, gastrointestinal stromal tumor metastases, and squamous cell carcinoma in one patient each. Ex vivo procedures were performed twice, and total vascular isolation was used in the nine other cases. The IVC was reconstructed with ringed Gore-Tex tube graft (five), primarily (five), or with Gore-Tex patches (one). There were two early deaths: one from liver failure at 3 weeks and one from sepsis secondary to a perforated segment of small bowel 4 months postresection. One patient with a gastrointestinal stromal tumor died at 32 months of recurrent tumor and one patient with hepatocellular carcinoma is alive with recurrent tumor at 16 months. The remaining patients are alive and disease free with follow-up ranging from 3 to 40 months without evidence of IVC occlusion. Combined resection of the liver and IVC is a formidable undertaking with substantial surgical risk. However, this aggressive surgical approach offers a chance for cure in patients with tumors involving the IVC that would otherwise have a dismal prognosis.
Improving the minimum Bayes’ risk combination of machine translation systems

We investigate the problem of combining the outputs of different translation systems into a minimum Bayes’ risk consensus translation. We explore different risk formulations based on the BLEU score, and provide a dynamic programming decoding algorithm for each of them. In our experiments, these algorithms generated consensus translations with better risk, and more efﬁ-ciently, than previous proposals
Suppression of Corrosion Growth of Stainless Steel by Ultrasound

Metals are smelted from natural minerals and they tend to return back to their original or stable states including oxides and hydroxides. One of the later processes is corrosion, which occurs from metal surfaces with surrounded air or electrolytes. With the propagation of corrosion, the metal becomes thin as well known as the uniform corrosion of carbon steels, holes appear from the surface such as pitting corrosion of stainless steels, or cracks initiate and propagate from or in the metal like stress corrosion cracking, hydrogen embrittlement or corrosion fatigue. In many cases, cracks initiate from pitting corrosion. Either of the above phenomena leads certainly to the strength loss of metals and accordingly largely shorten the structures‘ life. Before carrying out a maintenance of metallic structures, the ultrasound is frequently used to investigate the degradation level of the structures by comparing the emitted and the reflected waves. Many researches and applications have been carried out on this topic.
Performance analysis of token bus LAN in coordinating multiple robots

Using a local area network (LAN) to coordinate multiple industrial robots in a multirobot system (workcell) is studied. The properties of the multiple robot coordination task are first discussed. Then, a method is proposed to evaluate a pre-defined task decomposition and allocation scheme for the coordination task. In this method, a parameter called effective token passing ratio (ETPR) is defined to measure how efficient the scheme is when the token bus LAN is used as the communication medium. A lower bound of the ETPR is analytically determined based on time constraints imposed on the task. By using this method, one does not need to determine the communication delay and computation time of individual tasks (or subtasks) decomposed from the coordination task. Instead, one can compare the ETPR of the network with the lower bound. From the comparison, it can be determined whether the task decomposition and allocation scheme is appropriate. The probability that real-time coordination is successful is also computed. <<ETX>>
Setting Retail Staffing Levels: A Methodology Validated with Implementation

Problem definition: How should retail staffing levels be set? While cost of labor is well understood, the revenue implications of having the right staffing level are hard to estimate. Moreover, these implications vary by store; hence, staffing levels should vary as well. Academic/practical relevance: We provide a novel method for setting store associate staffing at the individual store level. We discuss a field implementation that tested this methodology. Methodology: We use historical data on revenue and planned and actual staffing levels by store to estimate how revenue varies with the staffing level at each store. We disentangle the endogeneity between revenue and staffing levels by focusing on randomly occurring deviations between planned and actual labor. Using historical analysis as a guide, we validate these results by changing the staffing levels in a few test stores. We implement the results chain-wide and measure the impact in a large specialty retailer. Results: We find that the implementation validates predictions of the historical analysis. The implementation in 168 stores over six months produces a 4.5% revenue increase and a nearly $7.4 million annual profit increase. The impact of staffing level on revenue varies greatly by store. Managerial implications: Our paper makes three contributions to academic literature and to retail practice. First, we describe a process by which retailers can improve the most common industry practice: set store labor to be proportional to forecasted store revenue. Our proposed approach systematically sets the labor level in each store. Second, we demonstrate the effectiveness of that process via a field test and then via chain-wide implementation over a six-month time period. Finally, most retailers set store labor at the same level across stores, proportionate to revenue. We show that this is not the best approach because the revenue impact of store labor varies by store. The stores in our study that could benefit from relatively more labor were those with high potential demand, closely located competition for that demand, and experienced store managers. Overall, we provide the first simple but rigorous, field-tested approach that any retailer can use to increase revenue and profitability through better labor management.
Identification of novel germline polymorphisms governing capecitabine sensitivity

Capecitabine, an oral 5‐fluorouracil (5‐FU) prodrug, is widely used in the treatment of breast, colorectal, and gastric cancers. To guide the selection of patients with potentially the greatest benefit of experiencing antitumor efficacy, or, alternatively, of developing toxicities, identifying genomic predictors of capecitabine sensitivity could permit its more informed use.
Generalized Linear Mixed Model : A Conditional Model

Correlated data are extensively used across disciplines when modeling data with any type of correlation that may exist among observations due to clustering or repeated measurements. When modeling clustered data, Hierarchical linear modeling is a popular multilevel modeling technique which is widely used in different fields such as education and health studies (Gibson & Olejnik, 2003). A typical example of multilevel data involves students nested within classrooms that behave similarly due to shared situational factors. Ignoring their correlation may result in underestimated standard errors and inflated type-I error (Raudenbush & Bryk, 2002). When modeling longitudinal data, many studies have been conducted on continuous outcomes; however, fewer studies on discrete responses over time have been completed. These studies require models within conditional, transitional and marginal models (Fitzmaurice, Davidian, Verbeke, & Molenberghs, 2009). Examples of such models which enable researchers to account for the autocorrelation among repeated observations include Generalized Linear Mixed Model, Generalized Estimating Equations, Alternating Logistic Regression and Fixed Effects with Conditional Logit Analysis. This study explores the aforementioned methods as well as several other correlated modeling options for longitudinal and hierarchical data within SAS 9.4. These procedures include PROC GLIMMIX, PROC GENMOD, PROC GEE, PROC PHREG, PROC MODEL and PROC MIXED.
Stability of Lagrangian Duality for Nonconvex Quadratic Programming Solution Methods and Applications in Computer Vision

L'etude de la stabilite de la dualite Lagrangienne relative au probleme de minimisation d'une forme quadratique non convexe sur une boule euclidienne est presentee. Elle permet d'etablir les caracterisations completes des solutions optimales globales du probleme. Pour la resolution duquel nous proposons deux algorithmes globaux de type primal-dual bases sur ces resultats theoriques. Une des applications importantes de ces algorithmes concerne le calcul d'un pas de deplacement dans les methodes de region de confiance qui sont reconnues tres robustes et performantes pour les problemes d'optimisation non lineaire. Nous discutons aussi des modelisations mathematiques des problemes importants rencontres en Vision par Ordinateur La plupart peuvent etre formules comme un probleme de moindres carres non lineaires. Finalement une methode pratique de region de confiance est proposee pour ces problemes qui semble tres bien adaptee a nos applications.
Viral Capsids and Envelopes: Structure and Function

Virus particles contain the viral genome packaged in a protein coat called the capsid. For some viruses, the capsid is surrounded by lipid bilayer that contains viral proteins, usually including the proteins that enable the virus to bind to the host cells. This lipid and protein structure is called the virus envelope, and is derived from the host cell membranes. The capsid and envelope play many roles in viral infection, including virus attachment to cells, entry into cells, release of the capsid contents into the cells, and packaging of newly formed viral particles. The capsid and envelope are also responsible for transfer of the viral genetic material from one cell to another. These structures also determine the stability characteristics of the virus particle, such as resistance to chemical or physical inactivation. Key concepts: Viral genetic material is packaged inside protein structures called capsids. Viruses are divided into two groups: enveloped viruses are surrounded by an outer lipid membrane; nonenveloped viruses lack this membrane. Where present, the envelope contains the viral proteins, which mediate binding to host cells. Where no envelope is present, this function is carried out by the outer capsid proteins. In general, nonenveloped viruses are more stable and can survive much longer in the environment. Capsids and envelopes determine the method of viral entry into and exit from host cells. Keywords: icosahedral symmetry; helical symmetry; membrane protein; receptor; virus entry; virus assembly
Impacts of Atmospheric Nitrogen Deposition on Surface Waters of the Western North Atlantic Mitigated by Multiple Feedbacks

The impacts of Atmospheric Nitrogen Deposition (AND) on the chlorophyll and nitrogen dynamics of surface waters in the western North Atlantic (25–45°N, 65–80°W) are examined with a biogeochemical ocean model forced with a regional atmospheric chemistry model (Community Multi-scale Air Quality model, CMAQ). CMAQ simulations with year-specific emissions reveal the existence of a ‘hot-spot’ of AND over the Gulf Stream. The impact of the hot-spot on the oceanic biogeochemistry is mitigated in three ways by physical and biogeochemical processes. First, AND significantly contributes to surface oceanic nitrogen concentrations only during the summer period, when the stratification is maximal and the background nitrogen inventories are minimal. Second, the increase in summer surface nitrate concentrations is accompanied by a reduction in upward nitrate diffusion at the base of the surface layer. This negative feedback partly cancels the nitrogen enrichment from AND. Third, gains in biomass near the surface force a shoaling of the euphotic layer and a reduction of about 5% in deep primary production and biomass on the continental shelf. Despite these mitigating processes, the impacts of AND remain substantial. AND increases surface nitrate concentrations in the Gulf Stream region by 14% during the summer (2% on average over the year). New primary production increases by 22% in this region during summer (8% on average). Although these changes may be difficult to distinguish from natural variability in observations, the results support the view that AND significantly enhances local carbon export.
An epidemic model with nonlocal diffusion on networks

We consider a SIS system with nonlocal diffusion which is the continuous version of a discrete model for the propagation of epidemics on a metapopulation network. Under the assumption of limited transmission, we prove the global existence of a unique solution for any diffusion coefficients. We investigate the existence of an endemic equilibrium and prove its linear stability, which corresponds to the loss of stability of the disease-free equilibrium. In the case of equal diffusion coefficients, we reduce the system to a Fisher-type equation with nonlocal diffusion, which allows us to study the large time behaviour of the solutions. We show large time convergence to either the disease-free or the endemic equilibrium.
D ec 2 01 5 Van der Waals interactions in rare-gas dimers : The role of interparticle interactions

Abstract We investigate the potential energy curves of rare-gas dimers with various ranges and strengths of interparticle interactions (nuclear-electron, electron-electron, and nuclear-nuclear interactions). Our investigation is based on the highly accurate coupled-cluster theory associated with those interparticle interactions. For comparison, the performance of the corresponding Hartree-Fock theory, second-order Møller-Plesset perturbation theory, and density functional theory is also investigated. Our results reveal that when the interparticle interactions retain the long-range Coulomb tails, the nature of van der Waals interactions in the rare-gas dimers remains similar. By contrast, when the interparticle interactions are sufficiently short-range, the conventional van der Waals interactions in the rare-gas dimers completely disappear, yielding purely repulsive potential energy curves.
Comparison of Bergeron and frequency-dependent cable models for the simulation of electromagnetic transients

The simulation of electromagnetic transients involving underground cables is very time consuming, when compared with simulations involving overhead lines, and Bergeron models are often used instead of the more accurate frequency-dependent models, in order to reduce the simulation time. This paper analyses the simulation errors of different Bergeron models to a reference frequency-dependent model for a 150kV cable. The simulations consider flat and trefoil installation, both-ends bonding and cross-bonding, ideal voltage source and modelling of the area around the cable. The Bergeron model is simulated for three different target frequencies: transient's resonance frequency, 50Hz and an in-between frequency. The results are analysed theoretically using modal propagation theory and the error is quantified for the case under examination. It is concluded that for a realistic case, which requires the modelling of the area around the cable being energised, the Bergeron model has a small error if tuned for the right frequency.
The specificity of SRC Homology 3 (SH3) domain interactions is modulated by their protein context in vivo

SRC Homology 3 (SH3) domains contribute to cellular processes via their ability to support protein-protein interactions (PPIs). While the intrinsic binding specificities of SH3 domains have been studied in vitro, whether each domain is necessary and sufficient to define PPI specificity in vivo is largely unknown. We combine genome editing, deep mutagenesis scanning, PPI mapping, growth phenotyping and single cell imaging in yeast to identify SH3-dependent PPI networks and their associated phenotypes. We show that both the sequence of the SH3 host protein and the position of the SH3 domains within their host are critical for interaction specificity and for cellular processes such as endocytosis. We further validate these findings using a human multi-SH3 adaptor protein and investigating its ability to promote phase separation. Our work highlights the importance of the interplay between a SH3 domain and its host protein for the regulation of cellular and biophysical processes.
Ribosomal Intergenic Spacer: A Polymerase Chain Reaction Diagnostic for Meloidogyne chitwoodi, M. fallax, and M. hapla.

ABSTRACT Polymerase chain reaction amplification of the intergenic spacer region between the 5S and 18S genes from Meloidogyne chitwoodi, M. fallax, and M. hapla enabled these three important temperate species to be differentiated. Length polymorphism was found between M. chitwoodi and M. fallax as a result of differing numbers of short repeats located between the 5S and 18S genes. The presence of the 5S gene within the rDNA cistrons was confirmed in the Meloidogyne spp. included in this study. The region between the 28S and 5S genes for M. chitwoodi and M. fallax was short and lacked variability in repeated sequences compared with the main tropical Meloidogyne spp. and M. hapla. Differences in the number of these repeats resulted in intraspecific length polymorphism for M.hapla.