Miracle-dz/UniFAR-FTUs huggingface dataset:
Turbulence and the dynamics of coherent structures. II. Symmetries and transformations

l. Introduction. The accurate determindtion of coherent structures depends upon having a sufficiently large database. As we will see in this part, symmetry considerations can considerably extend the amount of available data. In addition, a priori consideration of symmetries can be significant in designing numerical or physical experiments. In the following we outline, on a case by case basis, and sometimes only in brief, the effect of such deliberations for a number of standard geometries. We then show how such data can be transformed for use in related geometries.
Children's Perceptions of the Role of Police: A Qualitative Study

A qualitative methodology, using open-ended questions, was employed to explore the perceptions of 112 children regarding the role of police. The children, aged 5 to 6 and 7 to 8 years, were asked to comment on what police officers do when they go to work, what direct and indirect experiences they have had with the police, and the positive and negative aspects of being a police officer. The findings revealed that children emphasise the punitive role of police; very few children identified with non-punitive roles. This punitive theme was evident irrespective of the children's experiences, age, and whether they could recall television shows involving police. The practical implications of our findings for police relations with children, particularly in a forensic interview context, are discussed.
INTERSEX IDENTITIES

This article analyzes the sex and gender identity rhetoric of members of the Intersex Society of North America, which is a self-help and advocacy group whose main goals are to stop unnecessary genital surgery in ambiguously sexed infants and make medical histories available to adult intersexuals. By examining the organization's indebtedness to feminist and gay/lesbian/transperson theory and practice, the article shows how these political movements have progressively challenged the equation of sex with gender and how intersexuality exemplifies the theoretical and practical problems of identity politics.
Robust statistical registration of 3D ultrasound images using texture information

A new registration method for ultrasound volumes relying on on a statistical texture-based similarity measure is investigated. Texture information is given by spatial Gabor filters and represented by statistical kernel-based distributions. The registration similarity measure is then defined as a probabilistic distance, derived from Bhattacharyya coefficient, between two statistical distributions. Given this similarity measure, parametric ultrasound image registration is stated as a robust minimization issue. We also exploit frequency properties of spatial Gabor filters to propose a multiresolution approach to perform this minimization. We provide a preliminary evaluation of the new registration technique on clinical data.
IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice1

We previously demonstrated that a specialized subset of immature myeloid cells migrate to lymphoid organs as a result of tumor growth or immune stress, where they suppress B and T cell responses to Ags. Although NO was required for suppression of mitogen activation of T cells by myeloid suppressor cells (MSC), it was not required for suppression of allogenic responses. In this study, we describe a novel mechanism used by MSC to block T cell proliferation and CTL generation in response to alloantigen, which is mediated by the enzyme arginase 1 (Arg1). We show that Arg1 increases superoxide production in myeloid cells through a pathway that likely utilizes the reductase domain of inducible NO synthase (iNOS), and that superoxide is required for Arg1-dependent suppression of T cell function. Arg1 is induced by IL-4 in freshly isolated MSC or cloned MSC lines, and is therefore up-regulated by activated Th2, but not Th1, cells. In contrast, iNOS is induced by IFN-γ and Th1 cells. Because Arg1 and iNOS share l-arginine as a common substrate, our results indicate that l-arginine metabolism in myeloid cells is a potential target for selective intervention in reversing myeloid-induced dysfunction in tumor-bearing hosts.
Evaluation of SNOMED Coverage of Veterans Health Administration Terms

Veterans Health Administration (VHA) is now evaluating use of SNOMED-CT. This paper reports the first phase of this evaluation, which examines the coverage of SNOMED-CT for problem list entries. Clinician expressions in VA problem lists are quite diverse compared to the content of the current VA terminology Lexicon. We selected a random set of 5054 narratives that were previously "unresolved" against the Lexicon. These narratives were mapped to SNOMED-CT using two automated tools. Experts reviewed a subset of the tools' matched, partly matched, and un-matched narratives. The automated tools produced exact or partial matches for over 90% of the 5054 unresolved narratives. SNOMED-CT has promise as a coding system for clinical problems. In subsequent studies, VA will examine the coverage of SNOMED for other clinical domains, such as drugs, allergies, and physician orders.
Agreement between Children's and Mothers' Perceptions of Maternal Acceptance and Rejection: A Comparative Study in Finland and Pakistan

The primary purpose of this study was to explore the relative level of agreement or disagreement between mothers' reports versus children's reports of maternal acceptance-rejection in Finland and Pakistan. Of special interest was the question whether the level of agreement varied significantly in loving families (as defined by children) versus less than loving families (as defined by children). Data were collected from 144 mother/child dyads. The Child version of the Parental Acceptance-Rejection Questionnaire for Mothers (Child PARQ: Mother) and the Parent version of the Parental Acceptance-Rejection Questionnaire for Mothers (Parent PARQ: Mother) were used for these assessments. Results showed that, overall, children in both nations experienced considerable maternal acceptance, and that, overall, there appeared to be a significant level of agreement between mothers' reports and children's reports in both nations; however, the level of agreement was much higher in loving families than in less than loving families.
Aligning as a Team: Forms of Conjoined Participation in (Stepfamily) Interaction

Prior research (Falk, 1979; Kangasharju, 1996; Lerner, 1987, 1993) has suggested that individuals participate as teams in interaction by aligning supportively with one another and by sharing turns at talk or speaking on behalf of the team. In this article, I explore more closely how participants "do" team talk by analyzing excerpts from two audiotaped stepfamily mealtime interactions. In the analysis, I identify three forms of participation that teams enact in these data. Team members (a) share turns, (b) alternate turns parallel in function, and (c) situate their conversational contributions within a shared "knowledge schema" (Tannen & Wallat, 1993). In this article, I add to work on teams in interaction by illustrating how teams form and function moment by moment, by identifying previously unidentified forms of team participation, and by demonstrating in what ways extrainteractional characteristics of interlocutors can serve as a basis for creating particular alignments at particular moments in conversation. In the analysis, I also identify stepfamilies as an ideal site for examining shifting alignments in conversation and discuss how teams relate to negotiating relationships in this context.
The Relationship Between Schools, Friends and Smoking Initiation in Elementary School Students

ii I hereby declare that I am the sole author of this thesis. This is a true copy of the thesis, and includes any required final revisions, as accepted by my examiners. I understand that my thesis may be made electronically available to the public. Abstract Introduction: Smoking rates among senior students have been related to smoking initiation in
Housing People with Mental Illnesses: The Discursive Construction of Worthiness

Abstract This article examines how written and spoken language are used to categorize potential residents for supported housing designated for people diagnosed with severe mental illnesses. It examines the discursive work of agency representatives as they construct versions of clients as appropriate or inappropriate for housing. I show that what appear to be clear cut criteria for admission such as medication compliance, no history of violent behaviour and no active addictions are in fact contingent, locally negotiated categories that are used by agency representatives in flexible ways to determine worthiness for admission to supported housing. The categorization work of agency representatives in turn produces the meanings of the categories themselves. In doing the discursive work of categorization, agency representatives negotiate a “dilemma of caring” in which they must tread a careful path between the directives of the organizations they work for and their view of themselves as caring professionals. They also reaffirm the hegemonic bio‐medical understanding of mental illnesses as “real” biological entities.
Fluoxetine Inhibits Multidrug Resistance Extrusion Pumps and Enhances Responses to Chemotherapy in Syngeneic and in Human Xenograft Mouse Tumor Models

Multidrug resistance (MDR) operated by extrusion pumps such as P-glycoprotein and multidrug-resistance-associated-proteins, is a major reason for poor responses and failures in cancer chemotherapy. MDR modulators (chemosensitizers) were found among drugs approved for noncancer indications and their derivatives. Yet toxicity, adverse effects, and poor solubility at doses required for MDR reversal prevent their clinical application. Among newly designed chemosensitizers, some still suffer from toxicity and adverse effects, whereas others progressed to clinical trials. Diversities among tumors and among MDR pumps indicate a need for several clinically approved MDR modulators. Here we report for the first time that fluoxetine (Prozac), the well-known antidepressant, is a highly effective chemosensitizer. In vitro, fluoxetine enhanced (10- to 100-fold) cytotoxicity of anticancer drugs (doxorubicin, mitomycin C, vinblastine, and paclitaxel) in drug-resistant but not in drug-sensitive cells (5 and 3 lines, respectively). Fluoxetine increased drug accumulation within MDR-cells and inhibited drug efflux from those cells. In vivo, fluoxetine enhanced doxorubicin accumulation within tumors (12-fold) with unaltered pharmacokinetics. In four resistant mouse tumor models of both syngeneic and human xenograft, combination treatment of fluoxetine and doxorubicin generated substantial (P < 0.001) improvements in tumor responses and in survivals (2- to 3-fold). Moreover, fluoxetine reversed MDR at doses that are well below its human safety limits, free of the severe dose-related toxicity, adverse effects, and poor solubility that are obstacles to other chemosensitizers. This low-dose range, together with the findings reported here, indicate that fluoxetine has a high potential to join the arsenal of MDR reversal agents that may reach the clinic.
Asset Pricing and Mispricing

In this paper we develop models for stock returns when stock prices are subject to stochastic mispricing errors. We show that expected rates of return depend not only on the fundamental risk that is captured by a standard asset pricing model, but also on the type and degree of asset mispricing, even when the mispricing is zero on average. Empirically, the mispricing induced return bias, proxied either by Kalman filter estimates or by volatility and variance ratio of residual returns, are shown to be significantly associated with realized risk adjusted returns.
Joint channel estimation and phase noise suppression for OFDM systems

A joint channel estimation and phase noise suppression scheme for orthogonal frequency-division multiplexing (OFDM) systems is proposed for a case where channel estimation is needed symbol by symbol. In the proposed scheme, channel estimation and phase noise suppression are performed iteratively via the expectation-maximization (EM) algorithm. The proposed algorithm mitigates the performance degradation due to phase noise effectively while providing an accurate channel estimate with comparatively few pilot subcarriers, so that the spectral efficiency of the OFDM system is improved.
Multimedia Markup Tools for OpenKnowledge

OpenKnowledge is a peer-to-peer system for sharing knowledge and is driven by interaction models that give the necessary context for mapping of ontological knowledge fragments necessary for the interaction to take place. The OpenKnowledge system is agnostic to any specific data formats that are used in the interactions, relying on ontology mapping techniques for shimming the messages. The potentially large search space for matching ontologies is reduced by the shared context of the interaction. In this paper we investigate what this means for multimedia data on the OpenKnowledge network by discussing how an existing application that provides multimedia annotation (the Semantic Logger) can be migrated into the OpenKnowledge domain.
Student reflection and learning through peer reviews

This paper describes lessons learnt whilst using an online peer review system in an undergraduate unit for pre-service teachers. In this unit, students learn to use information technologies as part of their future teaching practice. The unit aims to foster graduates who become lifelong reflective educators by providing opportunities to explore and reflect on how they might use technology in authentic learning situations. Whilst peer review is an appropriate activity for supporting critical thinking and reflective practice in this kind of unit, it requires a number of decisions to be made in relation to student preparation and support, implementation strategy, and technological infrastructure to make it work in specific contexts. Much research has been conducted in recent years to inform educators in making these decisions. However, there are still gaps in the research, particularly in how to improve the quality and consistency of feedback that students give to each other in their feedback. This paper describes the experiences of implementing an online peer review system aiming to improve quality and consistency of feedback. This exploration has revealed that we can learn much about ways to improve our teaching practices by giving students an opportunity to review each other's work and give feedback.
The PMC2NT domain of the catalytic exosome subunit Rrp6p provides the interface for binding with its cofactor Rrp47p, a nucleic acid-binding protein

The exosome complex is a key component of the cellular RNA surveillance machinery and is required for normal 3′ end processing of many stable RNAs. Exosome activity requires additional factors such as the Ski or TRAMP complexes to activate the complex or facilitate substrate binding. Rrp47p promotes the catalytic activity of the exosome component Rrp6p, but its precise function is unknown. Here we show that recombinant Rrp47p is expressed as an apparently hexameric complex that specifically binds structured nucleic acids. Furthermore, pull-down assays demonstrated that Rrp47p interacts directly with the N-terminal region of Rrp6p that contains the functionally uncharacterized PMC2NT domain. Strains expressing a mutant form of Rrp6p lacking the N-terminal region failed to accumulate Rrp47p at normal levels, exhibited a slow growth phenotype characteristic of rrp47-Δ mutants and showed RNA processing defects consistent with loss of Rrp47p function. These findings suggest Rrp47p promotes Rrp6p activity by facilitating binding via the PMC2NT domain to structural elements within RNA. Notably, characterized Rrp6p substrates such as the 5.8S+30 species are predicted to contain helices at their 3′ termini, while others such as intergenic or antisense cryptic unstable transcripts could potentially form extensive double-stranded molecules with overlapping mRNAs.
Molecular Phylogeny and Morphology of Mycosphaerella nawae, the Causal Agent of Circular Leaf Spot on Persimmon

Abstract In this study, the phylogeny and morphology of Mycosphaerella nawae (Dothideomycetes, Ascomycota) were examined using Korean and Japanese isolates, to establish the phylogenetic relationship between M. nawae and its allied species. Korean and Japanese isolates of M. nawae were collected from circular leaf spot-diseased leaves and were confirmed based on internal transcribed spacer (ITS) sequence data. Phylogenetic analysis was conducted using multiple genes, including the ITS region, 28S rDNA, β-tubulin, translation elongation factor-1α, and actin genes. Our results revealed that M. nawae is closely related to members of the genus Phaeophleospora but are distant from the Ramularia spp. In addition, microscopic analysis revealed pseudothecia on the adaxial and abaxial surface of overwintered diseased leaves (ODL) and only on the abaxial surface of diseased leaves. Ascospores are oval to fusiform, one-septate, tapered at both ends, 1.7~3.1 × 8.1~14.1 μm, and were observed in ODL. Conidia are oval, guttulate, one-septate, 3.5~4.9 × 12.8~19.8 μm, and barely discernable on 30-day cultures. To our knowledge, this is the first report on the phylogeny of M. nawae, which is closely related to the genus Phaeophleospora, especially P. scytalidii.
Hybrid state feedback stabilization with l 2 performance for discrete-time switched linear systems

In this paper, the co-design of continuous-variable controllers and discrete-event switching logics, both in state feedback form, is investigated for a class of discrete-time switched linear control systems. It is assumed that none of the subsystems is stabilized through a continuous state feedback alone. However, it is possible to stabilize the whole switched system via carefully designing both the continuous controllers and the switching logics. Sufficient synthesis conditions for this co-design problem are proposed here in the form of bilinear matrix inequalities, which is based on the argument of multiple Lyapunov functions. The closed-loop switched system forms a special class of linear hybrid system, and is shown to be asymptotically stable with a finite l 2 induced gain.
Pharmacological Characterization of JNJ-40068782, a New Potent, Selective, and Systemically Active Positive Allosteric Modulator of the mGlu2 Receptor and Its Radioligand [3H]JNJ-40068782

Modulation of the metabotropic glutamate type 2 (mGlu2) receptor is considered a promising target for the treatment of central nervous system diseases such as schizophrenia. Here, we describe the pharmacological properties of the novel mGlu2 receptor positive allosteric modulator (PAM) 3-cyano-1-cyclopropylmethyl-4-(4-phenyl-piperidin-1-yl)-pyridine-2(1H)-one (JNJ-40068782) and its radioligand [3H]JNJ-40068782. In guanosine 5′-O-(3-[35S]thio)triphosphate binding, JNJ-40068782 produced a leftward and upward shift in the glutamate concentration-effect curve at human recombinant mGlu2 receptors. The EC50 of JNJ-40068782 for potentiation of an EC20-equivalent concentration of glutamate was 143 nM. Although JNJ-40068782 did not affect binding of the orthosteric antagonist [3H]2S-2-amino-2-(1S,2S-2-carboxycyclopropyl-1-yl)-3-(xanth-9-yl)propanoic acid (LY-341495), it did potentiate the binding of the agonist [3H](2S,2′R,3′R)-2-(2′,3′-dicarboxylcyclopropyl)glycine (DCG-IV), demonstrating that it can allosterically affect binding at the agonist recognition site. The binding of [3H]JNJ-40068782 to human recombinant mGlu2 receptors in Chinese hamster ovary cells and rat brain receptors was saturable with a KD of ∼10 nM. In rat brain, the anatomic distribution of [3H]JNJ-40068782 was consistent with mGlu2 expression previously described and was most abundant in cortex and hippocampus. The ability of structurally unrelated PAMs to displace [3H]JNJ-40068782 suggests that PAMs may bind to common determinants within the same site. It is noteworthy that agonists also increased the binding affinity of [3H]JNJ-40068782. JNJ-40068782 influenced rat sleep-wake organization by decreasing rapid eye movement sleep with a lowest active dose of 3 mg/kg PO. In mice, JNJ-40068782 reversed phencyclidine-induced hyperlocomotion with an ED50 of 5.7 mg/kg s.c. Collectively, the present data demonstrate that JNJ-40068782 has utility in investigating the potential of mGlu2 modulation for the treatment of diseases characterized by disturbed glutamatergic signaling and highlight the value of [3H]JNJ-40068782 in exploring allosteric binding.
The Protease Activity of Yeast Separase (Esp1) Is Required for Anaphase Spindle Elongation Independently of Its Role In Cleavage of Cohesin

Separase is a caspase-family protease required for the metaphase–anaphase transition in eukaryotes. In budding yeast, the separase ortholog, Esp1, has been shown to cleave a subunit of cohesin, Mcd1 (Scc1), thereby releasing sister chromatids from cohesion and allowing anaphase. However, whether Esp1 has other substrates required for anaphase has been controversial. Whereas it has been reported that cleavage of Mcd1 is sufficient to trigger anaphase in the absence of Esp1 activation, another study using a temperature-sensitive esp1 mutant concluded that depletion of Mcd1 was not sufficient for anaphase in the absence of Esp1 function. Here we revisit the issue and demonstrate that neither depletion of Mcd1 nor ectopic cleavage of Mcd1 by Tev1 protease is sufficient to support anaphase in an esp1 temperature-sensitive mutant. Furthermore, we demonstrate that the catalytic activity of the Esp1 protease is required for this Mcd1-independent anaphase function. These data suggest that another protein, possibly a spindle-associated protein, is cleaved by Esp1 to allow anaphase. Such a function is consistent with the previous observation that Esp1 localizes to the mitotic spindle during anaphase.
Earnings Dynamics and Firm-Level Shocks

We use matched employer-employee data from Sweden to study the role of the firm in affecting the stochastic properties of wages. Our model accounts for endogenous participation and mobility decisions. We find that firm-specific permanent productivity shocks transmit to individual wages, but the effect is mostly concentrated among the high-skilled workers; firm-specific temporary shocks mostly affect the low-skilled. The updates to worker-firm specific match effects over the life of a firm-worker relationship are small. Substantial growth in earnings variance over the life cycle for high-skilled workers is driven by firms accounting for 44% of cross-sectional variance by age 55.
The Dynamics of Microtubule/Motor-Protein Assemblies in Biology and Physics

Many important processes in the cell are mediated by stiff microtubule polymers and the active motor proteins moving on them. This includes the transport of subcellular structures (nuclei, chromosomes, organelles) and the self-assembly and positioning of the mitotic spindle. Little is understood of these processes, but they present fascinating problems in fluid-structure interactions. Microtubules and motor proteins are also the building blocks of new biosynthetic active suspensions driven by motor-protein activity. These reduced systems can be probed—and modeled—more easily than can the fully biological ones and demonstrate their own aspects of self-assembly and complex dynamics. I review recent work modeling such systems as fluid-structure interaction problems and as multiscale complex fluids.