Miracle-dz/UniFAR-FTUs huggingface dataset:
Reducing the number of transistors with gate clustering

In this work a greedy cell clustering technique is proposed to reduce the number of transistors of circuits. Reducing the amount of transistors can provide leakage power reduction. The clusterization is applied to a set of connected cells with fanout one. These cells are replaced by a equivalent logic complex cell. Hereafter, the layout of any cluster can be automatically designed by using a layout generation tool. The ITC'99 benchmark circuits are synthesized to the 45nm Open Cell Library. The clustering technique presented in this work is able to provide a reduction in the number of transistors of 9.8%, on average, over the synthesis using all cells available in the library. We show that the set of logic functions used by the input netlist influences the results obtained by clustering. For a netlist synthesized without the complex cells of the library our clustering technique reduced the number of transistors in up to 22.3% when compared to the original netlist.
Influence of anesthetic regimens on the intestinal absorption of 5-fluorouracil in rats.

We investigated the influence of anesthetic regimens on the intestinal absorption of 5-fluorouracil (5-FU), which is known to be absorbed by concurrent Na(+)-dependent, carrier-mediated transport and passive transport, in single-pass perfusion experiments in rats. Compared with the absorption in unanesthetized rats, the regular dose of urethane (1.13g/kg) reduced the maximum transport rate (Jmax), the Michaelis constant (Km) and the membrane permeability coefficient of passive transport (P m,d); a low dose of urethane (0.7g/kg) reduced Jmax and Kmax, but did not affect Pm,d; pentobarbital sodium (50 mg/kg) increased Jmax without affecting Km, and reduced Pm,d. The reductions in Jmax and Km were comparable for the regular and low doses of urethane. Thus, urethane and pentobarbital, which have been most commonly used in laboratory animal experiments, exerted qualitatively different effects on the carrier-mediated transport of 5-FU, although they similarly inhibited the passive transport. For urethane, the effect on the passive transport was avoided by reducing the dose, but the effect on the carrier-mediated transport was not. This influence of anesthetic regimens on intestinal drug absorption may not be easily scaled for normalizing absorption data. When compiling them for such purposes as establishing in situ-in vivo quantitative correlation, the absorption data in perfusion (in situ) should be categorized on the basis of anesthetic regimens, to avoid ending up with poor outcomes. We also examined the effect of urethane on the exsorption of Na+ in the intestinal loop where Na+-free buffer was introduced, and found a minimal effect. (ABSTRACT TRUNCATED AT 250 WORDS)
A rapid molecular-based assay for direct quantification of viable bacteria in slaughterhouses.

A rapid test for microbial quantification in carcass and environmental swabs that does not require enrichment and provides results in less than 4 h is described here. Steps in the assay include the rapid concentration of bacteria on sponge swabs by vacuum filtration followed by real-time PCR detection. The assay has been applied for the detection of coliforms, Escherichia coli O157:H7, Salmonella spp. , and Listeria monocytogenes on carcass swabs and environmental samples in a slaughterhouse-processing line. Comparison of this rapid method with standard culture techniques for coliform counts on beef and pork carcass swabs revealed higher numbers of bacteria (2- to 50-fold) by the rapid test compared with the plate counts. This was due to the detection of all bacteria (live, dead, and non-culturable forms) in the rapid assay. To allow detection of only viable bacteria, concentrated samples were treated with ethidium monoazide (EMA) prior to DNA extraction and real-time PCR detection, thereby preventing the amplification of DNA from bacteria with damaged cell walls and allowing only the DNA from bacteria with intact membranes to be detected. EMA treatment resulted in a significant reduction (P < 0.001) in the number of coliforms detected compared to real-time PCR without EMA treatment. In beef swabs, the counts obtained in EMA real-time PCR were not significantly different (P < 0.08) from the culture counts and the correlation coefficient between the two assays was 0.7385. A lower correlation coefficient (0.402) was obtained with pork swabs. The assay described herein has the potential to be applied on a routine basis to slaughterhouse lines for the detection of indicator organisms or specific pathogens.
Admission biomarkers of trauma-induced secondary cardiac injury predict adverse cardiac events and are associated with plasma catecholamine levels

BACKGROUND Secondary cardiac injury and dysfunction may be important contributors to poor outcomes in trauma patients, but the pathophysiology and clinical impact remain unclear. Early elevations in cardiac injury markers have been associated with the development of adverse cardiac events (ACEs), prolonged intensive care unit stays, and increased mortality. Studies of preinjury &bgr;-blocker use suggest a potential protective effect in critically ill trauma patients. This study aimed to prospectively examine the association of early biomarker evidence of trauma-induced secondary cardiac injury (TISCI) and ACEs and to examine the potential contribution of circulating catecholamines to its pathophysiology. METHOD Injured patients who met the study criteria were recruited at a single major trauma center. A blood sample was collected immediately on arrival. Serum epinephrine (E), norepinephrine (NE), and cardiac biomarkers including heart-related fatty acid binding protein (H-FABP) were assayed. Data were prospectively collected on ACEs. RESULTS Of 300 patients recruited, 38 (13%) developed an ACE and had increased mortality (19% vs. 9%, p = 0.01) and longer intensive care unit stays (13 days, p < 0.001). H-FABP was elevated on admission in 56% of the patients, predicted the development of ACE, and was associated with higher mortality (14% vs. 5%, p = 0.01). Admission E and NE levels were strongly associated with elevations in H-FABP and ACEs (E, 274.0 pg/mL vs. 622.5 pg/mL, p < 0.001; NE, 1,063.2 pg/mL vs. 2,032.6 pg/mL, p < 0.001). Catecholamine effect on the development of TISCI or ACEs was not statistically independent of injury severity or depth of shock. CONCLUSION Admission levels of H-FABP predict the development of ACEs and may be useful for prognosis and stratification of trauma patients. The development of TISCI and ACEs was associated with high admission levels of catecholamines, but their role in pathogenesis remains unclear. Clinical trials of adrenergic blockade may have the potential to demonstrate outcomes in patients presenting with TISCI. LEVEL OF EVIDENCE Prognostic/epidemiologic study, level II.
Insecure attachment moderates women's adjustment to inflammatory bowel disease severity.

OBJECTIVE Insecure attachment was explored as a moderator of the relationship between disease severity and psychosocial variables in a study of adjustment in women with inflammatory bowel disease (IBD). METHOD Participants were 218 women recruited through notices placed in the community, in gastroenterologists' offices, and through online postings to support groups and message boards specifically for people with Crohn's disease, colitis, or IBD in general. Participants completed a mail-in or online survey assessing severity and frequency of symptoms, attachment style (separated into anxious and avoidant subscales), perceived social support, negative affect, and efficacy of coping with IBD. RESULTS Anxious and avoidant attachment styles were correlated positively with disease severity and negative affect and negatively with perceived social support and coping efficacy. Hierarchical regressions indicated that disease severity was most strongly associated with negative affect for high avoidant attachment, as compared with moderate and low avoidant attachment. Disease activity was inversely related to perceived social support and coping efficacy for high and moderate, but not low, anxious attachment. CONCLUSION Our study indicates that attachment moderates associations between disease severity in women with different kinds of IBD and psychological indicators of adjustment. Limitations and relationship to previous research on attachment and health are discussed.
Chirp Evolution Algorithm of a Dark-Optical-Comb Injection Mode-Locked SOA Fiber Laser Pulses During Soliton Compression

The chirp evolution of a dark-optical-comb injection harmonic mode-locked (HML) semiconductor optical amplifier fiber ring laser (SOAFL) with a nonlinearly driven electro-absorption modulator is demonstrated. The dispersion compensation of the 10-GHz HML-SOAFL pulse with a 100-m-long dispersion compensation fiber is performed to shorten the pulsewidth from 29 to 2.9 ps with a compression factor of 10, and a time bandwidth product (TBP) of 0.5. The soliton compression with a 10-m-long single-mode fiber is employed to deliver the amplified 10-GHz HML-SOAFL soliton pulse with a peak power of 38.2 W and a pulsewidth of 1.6 ps, while the spectrum is broadened from 1.4 to 2.3 nm with a TBP of 0.45. To monitor the dynamic chirp evolution, a second-harmonic generation frequency-resolved optical gating (SHG-FROG) is used to retrieve the amplitude and phase contour profile of the HML-SOAFL. The phase fitting result distinguishes the linear chirp from the nonlinear chirp associated with the HML-SOAFL pulse, which are 0.016 ps2 and 0.002 ps3. The Schrödinger equation assists to retrieve the phase evolution of the 10-GHz HML-SOAFL with negative group velocity dispersion. Disregarding the linear dispersion compensation and soliton compression, the original 10-GHz HML-SOAFL pulse with a negative GDD of -5 ps2 is quantified.
Rework risks triggers in the Nigerian construction industry: a view of built environment professionals

Rework is systemic and a recurring decimal and It is triggered by several factors, which emergence create scenarios, which degrades project cost, quality and schedule performance, and overall project performance. This study therefore examined the perception of construction professionals on the factors that triggers the emergence of rework in the Nigerian construction industry. This was achieved by determining the predominant rework triggers that affect project performance, identifying rework triggers in which the professionals view varies significantly, and examining the category of rework risks triggers that contribute more to rework incidences. The study adopted a quantitative survey approach in which structured questionnaire was adopted as the research instrument. Mean item score was used in ranking the professionals perception on rework triggers, and Kruskal-Wallis H test was used to identify the variables in which the professionals view varies. The study concluded that: contractor-related and design-related causes are the major categories of rework risks triggers. Unclear instruction to workers, Shortage of skilled supervisors, incomplete and inaccurate information are the predominant triggers of rework. The professionals view varies significantly on nine factors which cut across the four categories of rework triggers. It was recommended that there is need for clarity, effectiveness and timeliness of instruction and information dissemination among project participants, and the use of skilled and experienced professionals, skilled supervisors and proper implementation of quality management practices by both the design consultant and contractor throughout the project’s phases
The impact of coding process on observed cancer mortality trends in Switzerland

Official cancer mortality in Switzerland decreased by about 16% over the 9-year period 1990–1998 and this trend has often been used to suggest that secondary prevention by screening for breast cancer could be useless. However, the clear downshift observed between 1994 and 1995 for some cancers, such as female breast and prostate, and the simultaneous change in ICD classification used by the Federal Office for Statistics in 1995 (ICD-8 to ICD-10) could be related, suggesting an impact of coding process on the observed trend. For every death occurred between 1980 and 1999, the death certificates have been retrieved, the cause of death has been recoded and site-specific mortality rates have been calculated again for each year during this period. As suggested, the trend appears to be overestimated: in order to be comparable with current rates, the mortality observed before 1995 should be lowered by about 7% for men and 5% for women. The error may be partially due to attributing the cause of death to co-morbidity factors not normally (and nowadays) defined as the underlying cause. Logically, the impact of such a miscoding is more important among older people and for cancer sites with long survival. For instance, the correction should be around 15% for female breast, 12% for prostate and up to 40% for testicular cancer.
Examining obligations to society for QS Stars best ranked universities in social responsibility

Abstract Developing the local, regional, even national communities is often central to a university’s mission. This is a two-way process and both society and university itself should benefit from this collaboration. Universities around the world have been in the past decades required to leave their ivory tower and to become more involved in addressing the needs of the society and thus more relevant for the communities which they serve. They are expected to take a leadership role in implementation of the required change by contributing to community development through knowledge, innovations, skills and jobs. By taking a leading role in society and continuously innovating, universities will support communities with achieving a sustainable growth and therefore will contribute to increasing the well-being of society at large. The current paper aims to assess the university obligations to society by analyzing 27 universities around the world best ranked in social responsibility according to QS Stars University Rating 2016. In the paper, we discuss the extent to which different attributes of the university social responsibility are reflected among the initiatives and projects run by the universities included in the study. Also, an exploratory factor analysis was employed to identify underlying variables that explain the pattern of correlations between university social responsibility initiatives. Following the QS Stars methodology, the dimensions used to evaluate social responsibility of sampled universities included: community investment and development, social work and disaster relief, regional human capital development, and environmental impact. The results show that the level of involvement in social responsibility actions is high for all the universities included in the study. Also, the types of initiatives vary in terms of nature, intensity and impact for each one of the dimensions analyzed. Our research findings offer useful insights for both universities’ leaders and community developers in their joint-efforts to develop and grow a prosperous community.
Induction of Intestinal Multidrug Resistance-Associated Protein 2 by Glucagon-Like Peptide 2 in the Rat

The effects of glucagon-like peptide 2 (GLP-2) on expression and activity of jejunal multidrug resistance-associated protein 2 (Mrp2; Abcc2) and glutathione transferase (GST) were evaluated. After GLP-2 treatment (12 μg/100 g b.wt. s.c., every 12 h, for 5 consecutive days), Mrp2 and the α class of GST proteins and their corresponding mRNAs were increased, suggesting a transcriptional regulation. Mrp2 was localized at the apical membrane of the enterocyte in control and GLP-2 groups, as detected by confocal immunofluorescence microscopy. As a functional assay, everted intestinal sacs were incubated in the presence of 1-chloro-2,4-dinitrobenzene in the mucosal compartment, and the glutathione-conjugated derivative, dinitrophenyl-S-glutathione (DNP-SG; model Mrp2 substrate), was detected in the same compartment by high-performance liquid chromatography. A significant increase in apical secretion of DNP-SG was detected in the GLP-2 group, consistent with simultaneous up-regulation of Mrp2 and GST. GLP-2 also promoted an increase in cAMP levels as detected in homogenates of intestinal mucosa. Treatment of rats with 2′,3′-dideoxyadenosine (DDA), a specific inhibitor of adenylyl cyclase, abolished the increase in cAMP levels and Mrp2 protein promoted by GLP-2, suggesting cAMP as a mediator of Mrp2 modulation. Increased expression of Mrp2 and cAMP levels in response to GLP-2 occurred not only at the tip but also at the middle region of the villus, where constitutive expression of Mrp2 is normally low. In conclusion, our study suggests a role for GLP-2 in the prevention of cell toxicity of the intestinal mucosa by increasing Mrp2 chemical barrier function.
Hyperbilirubinemia and urinary tract infection: the effect of indirect hyperbilirubinemia on the in vitro growth of uropathogen Escherichia coli in newborn urine

Abstract High serum bilirubin is antioxidant and cytoprotective. We evaluated if urine samples of hyperbilirubinemic newborns impede uropathogenic Escherichia coli growth. Bag-urine samples of hyperbilirubinemic newborns (study group) were cultured at presentation and during remission. Urine sample were obtained only once from healthy newborns (control group). Escherichia coli [2 × 104 colony-forming unit (cfu)/mL] was inoculated into the sterile urine samples and colony counts were determined after 24 h. Bilirubin levels at presentation and remission were also recorded. Escherichia coli colony counts of the control versus study groups and of the presentation versus remission samples in the study group were compared. There were 13 study and 17 control cases. Escherichia coli colony counts were not different in the study group at presentation versus remission (5.4 ± 0.7 vs. 5.5 ± 0.8 log10, respectively; p = 0.659). Escherichia coli colony count of the control group (5.2 ± 0.6 log10) was also not different from the study group. In conclusion, the urine of hyperbilirubinemic newborns did not affect the growth rate of uropathogenic E. coli.
Surprise in Short Interest

We extract the news component of short-selling activity by accounting for important cross-sectional, distributional differences in short interest. The resulting measure of surprise in short interest negatively predicts the cross section of both U.S. and international equity returns. Our results also indicate that this predictability originates from short sellers' informed trading on mispricing and the market's underreaction to the news component of short-sale reports. Consistent with the notion of costly arbitrage, the return predictability is stronger among illiquid, volatile stocks and stocks with high information uncertainty, but importantly, unrelated short-selling frictions.
Pemetrexed as Second-Line Treatment in Malignant Pleural Mesothelioma after Platinum-Based First-Line Treatment

Introduction: Pemetrexed is active as first-line treatment of malignant pleural mesothelioma. The objective was to evaluate its activity as second-line treatment. Methods: Patients had disease progression of malignant pleural mesothelioma after previous platinum-based regimens without pemetrexed. Treatment was pemetrexed alone or pemetrexed combined with carboplatin. Pemetrexed dosing was 500 mg/m2 and carboplatin was AUC (area under the curve) 5 once every 3 weeks. Results: Thirty-nine patients were included: 28 Danish patients received pemetrexed (three patients received pemetrexed as third-line treatment), whereas 11 Norwegian patients received pemetrexed plus carboplatin. Most patients were men (90%), had epithelial subtype (85%), and International Mesothelioma Interest Group stages III to IV (77%). Median age was 62 years (range, 30–77). The median number of treatment courses was six (range, 1–23). Common Toxicity Criteria grade 3 to 4 toxicity occurred only with respect to leukocytopenia (pemetrexed: 14% of patients; pemetrexed plus carboplatin: 9%) and thrombocytopenia (pemetrexed: 7%; pemetrexed plus carboplatin: 18%). One patient receiving pemetrexed died of sepsis. Partial response rates were 21% and 18%, the median time to progression was 21 weeks (range, 4–92) and 32 weeks (range, 4–128+), and the median survival was 42 weeks (range, 4–99) and 39 weeks (range, 10–128+) with pemetrexed and pemetrexed plus carboplatin, respectively. Conclusions: Pemetrexed was generally well tolerated with noteworthy activity in malignant pleural mesothelioma after previous platinum-based treatment and may be considered for second-line treatment.
Genetic Relatedness of Coagulase-negative Staphylococci From Gastrointestinal Tract and Blood of Preterm Neonates With Late-onset Sepsis

Background: Coagulase-negative staphylococci (CoNS) are the first colonizers of gastrointestinal tract (GIT) and the commonest cause of late-onset sepsis (LOS) in preterm neonates. Intravascular catheters are considered a major source of CoNS bacteremia. However, several cases of LOS remain without an identified source. To elucidate whether GIT could be a potential source of invasive strains, we aimed to assess the molecular similarity between CoNS from blood and GIT in preterm neonates with LOS. Methods: Altogether 22 blood and 53 GIT isolates collected from 22 neonates with LOS caused by CoNS (Staphylococcus haemolyticus in 13, Staphylococcus epidermidis in 7 and Staphylococcus hominis in 2 patients) were included. Rectal swabs were collected twice weekly from birth, but only isolates obtained before LOS were analyzed. S. epidermidis isolates were typed by multilocus variable number of tandem repeats analysis and multilocus sequence typing, S. haemolyticus by pulsed-field gel electrophoresis. Results: Eighteen of 22 neonates had the same CoNS species in GIT and bloodstream; all these isolates from them (altogether 18 blood and 28 GIT isolates) underwent typing. The genotypic similarity between bloodstream and ≥1 antecedent GIT isolates was observed in 13 of 18 patients—3 of 7 with S. epidermidis and 10 of 11 with S. haemolyticus infection. The concordant GIT isolates were collected 0–7 days before the positive blood culture. Conclusions: The similarity between CoNS from GIT and bloodstream indicates that preterm neonates harbour invasive strains in GIT before LOS. Whether there is a causal relationship between GIT colonization and LOS remains to be elucidated in further studies.
A mixed-signal front-end ASIC for EEG acquisition system

A mixed-signal front-end ASIC for an Electroencephalogram (EEG) acquisition system is presented. It will be attached to the scalp by electrodes and detects the electrical signals from the brain, amplifies them, and converts the signals into digital data. 8 EEG channels are integrated. In each channel the EEG signals are amplified by a pre-amplifier with a gain between 10 and 1000. Following the pre-amplifier a two-stage low pass filter is applied with a selectable band of 80 Hz or 800 Hz. The whole channel has input referred noise of 2.2 μV for a signal bandwidth of 1 Hz-1 kHz. The analog to digital converter (ADC) is based on successive approximation algorithm with a resolution of 12 bit. The analog part for the ASIC consumes 3.5 mW from 1.8 V supply and occupies 4.08 mm2 in 180 nm CMOS technology.