Miracle-dz/UniFAR-FTUs huggingface dataset:
EMD based fault diagnosis for the sliding bearings with measurement noise

Empirical Mode Decomposition (EMD) is a decomposition algorithm which is used to analyze signal. In this paper, a new fault diagnosis approach, which is the EMD based on the optimization of noise reduction, is proposed for bearings. Firstly, the original signal is decomposed into a set of Intrinsic Mode Functions (IMFs) by EMD combined with Genetic Algorithm (GA) for reconstruction. Then effective IMFs are selected as characteristics by sample entropy, which are trained and classified by Support Vector Machine (SVM) to make fault diagnosis. Finally, an experiment is carried out to verify the efficiency of the proposed method.
Integrative approaches for modeling regulation and function of the respiratory system

Mathematical models have been central to understanding the interaction between neural control and breathing. Models of the entire respiratory system—which comprises the lungs and the neural circuitry that controls their ventilation—have been derived using simplifying assumptions to compartmentalize each component of the system and to define the interactions between components. These full system models often rely—through necessity—on empirically derived relationships or parameters, in addition to physiological values. In parallel with the development of whole respiratory system models are mathematical models that focus on furthering a detailed understanding of the neural control network, or of the several functions that contribute to gas exchange within the lung. These models are biophysically based, and rely on physiological parameters. They include single‐unit models for a breathing lung or neural circuit, through to spatially distributed models of ventilation and perfusion, or multicircuit models for neural control. The challenge is to bring together these more recent advances in models of neural control with models of lung function, into a full simulation for the respiratory system that builds upon the more detailed models but remains computationally tractable. This requires first understanding the mathematical models that have been developed for the respiratory system at different levels, and which could be used to study how physiological levels of O2 and CO2 in the blood are maintained. WIREs Syst Biol Med 2013, 5:687–699. doi: 10.1002/wsbm.1244
Implications of European Trading for the New York Stock Exchange Open

We test the hypothesis that a market maker in New York faces a more competitive market for cross-listed European firms trading simultaneously in their home market during overlapping trading hours as compared to U.S. firms which trade mainly in New York. A sample of seventy two European firms is matched with a control group of U.S. firms, under the same industry and with same liquidity. We find that the mean percentage bid-ask spread for the European firms is significantly smaller than that of the U.S. firms for the opening thirty minutes of trading at the NYSE, even after controlling for liquidity and probability of informed trading. When we compare the percentage bid-ask spreads during the NYSE afternoon after the European markets have closed trading, we find no significant difference. This suggests that the U.S. and the European markets are integrated during the period of overlap and synergies exist between trading venues.
The polymorphism of aspirin

Mitchell & Saville (1967) demonstrated that various samples of commercial aspirin have different rates of dissolution. Subsequently, Tawashi (1968, 1969) has reported the existence of aspirin in two polymorphic forms (designated Forms I and 11). During the course of present work concerned with the tabletting characteristics of various polymorphic forms of drugs, we have been able to identify several aspirin polymorphs in addition to those already reported. Table 1 shows the conditions under which the polymorphs were obtained. Confirmatory evidence that all the samples examined were aspirin and differed only in crystalline form is afforded by the fact that no differences could be detected in their ultraviolet spectra when dissolved in ethanol (determined using a Unicam SP800 recording spectrophotometer). A Perkin-Elmer Differential Scanning Calorimeter DSC-1 equipped with an effluent analyser was used for the thermal analysis of the polymorphs. Samples weighing between 2 and 10 mg were analysed using a scanning rate of 8" min-l. No traces of solvent of crystallization were detected by the effluent analyser when any of the aspirin samples were fused. This therefore excludes the possibility that the samples were solvated forms of aspirin. The DSC traces for the six polymorphs are shown in Fig. 1. A Kofler hot stage microscope was used to confirm the melting points of the polymorphs. The results are shown in Table 1. The instrument was also used to observe solution phase transformations of pairs of polymorphs. The solvent for this work was n-pentanol saturated with one component of the particular polymorph pair under study. Some of the phase transformations are summarized in Table 2. Since different polymorphs have different crystal packing conditions, it is to be expected that they will have different true densities. Density determinations were made at 20" using a specific gravity bottle with a displacement medium of light liquid paraffin. Table 1 contains the results of this work.
The Contribution of Low-Energy Protons to the Total On-Orbit SEU Rate

Low- and high-energy proton experimental data and error rate predictions are presented for many bulk Si and SOI circuits from the 20-90 nm technology nodes to quantify how much low-energy protons (LEPs) can contribute to the total on-orbit single-event upset (SEU) rate. Every effort was made to predict LEP error rates that are conservatively high; even secondary protons generated in the spacecraft shielding have been included in the analysis. Across all the environments and circuits investigated, and when operating within 10% of the nominal operating voltage, LEPs were found to increase the total SEU rate to up to 4.3 times as high as it would have been in the absence of LEPs. Therefore, the best approach to account for LEP effects may be to calculate the total error rate from high-energy protons and heavy ions, and then multiply it by a safety margin of 5. If that error rate can be tolerated then our findings suggest that it is justified to waive LEP tests in certain situations. Trends were observed in the LEP angular responses of the circuits tested. Grazing angles were the worst case for the SOI circuits, whereas the worst-case angle was at or near normal incidence for the bulk circuits.
Development and performance of an enzyme immunoassay to detect creatine kinase isoenzyme MB activity using anti-mitochondrial creatine kinase monoclonal antibodies

Abstract Objective: The MB fraction of creatine kinase (CK-MB) has long been used as a cardiac marker. It is known that the CK-MB immunoinhibition method lacks selectivity and accuracy, because the appearance of macro CK type 2, corresponding to mitochondrial creatine kinase (MtCK) in some patient serum may render CK-MB activity measured by conventional method abnormally high. Thus, to improve the specificity and accuracy of the CK-MB assay, we developed two types of monoclonal anti-MtCK antibodies against sarcomeric MtCK and ubiquitous MtCK, and present herein the performance of a new method using these antibodies. Material and methods: The performance of our test for detecting CK-MB activity was compared with other methods, and the range of CK-MB activities in normal human serum was investigated. Results: The two types of monoclonal antibodies developed by us were isoenzyme-specific to sMtCK or uMtCK. The correlation coefficients of our method and conventional method to electrophoresis were 0.973 and 0.873, respectively. The mean CK-MB activity in normal human serum by our method and the conventional method was 2.4 and 11.7 U/L, respectively. Thus, our data indicated that about 80% of CK-MB activity, determined using the conventional method, seems to correspond to the MtCK activity. Conclusion: Our method is novel in offering higher accuracy of measuring true CK-MB contents in human serum as compared to the conventional method. The possibility of accurately estimating CK-MB activity by our method which can inhibit MtCKs in healthy person and patient serum is likely to bring a break-through in clinical diagnostics.
Optimal Generation Mix With Short-Term Demand Response and Wind Penetration

Demand response, defined as the ability of load to respond to short-term variations in electricity prices, plays an increasingly important role in balancing short-term supply and demand, especially during peak periods and in dealing with fluctuations in renewable energy supplies. However, demand response has not been included in standard models for defining the optimal generation technology mix. Three different methodologies are proposed to integrate short-term responsiveness into a generation technology mix optimization model considering operational constraints. Elasticities are included to adjust the demand profile in response to price changes, including cross-price elasticities that account for load shifts among hours. As energy efficiency programs also influence the load profile, interactions of efficiency investments and demand response are also modeled. Comparison of model results for a single year optimization with and without demand response shows peak reduction and valley filling effects, impacting the optimal amounts and mix of generation capacity. Increasing demand elasticity also increases the installed amount of wind capacity, suggesting that demand response yields environmental benefits by facilitating integration of renewable energy.
A high-order gradient model for wave propagation analysis of porous FG nanoplates

A high-order nonlocal strain gradient model is developed for wave propagation analysis of porous FG nanoplates resting on a gradient hybrid foundation in thermal environment, for the first time. Material properties are assumed to be temperature-dependent and graded in the nanoplate thickness direction. To consider the thermal effects, uniform, linear, nonlinear, exponential, and sinusoidal temperature distributions are considered for temperature-dependent FG material properties. On the basis of the refined-higher order shear deformation plate theory (R-HSDT) in conjunction with the bi-Helmholtz nonlocal strain gradient theory (B-H NSGT), Hamilton's principle is used to derive the equations of wave motion. Then the dispersion relation between frequency and wave number is solved analytically. The influences of various parameters (such as temperature rise, volume fraction index, porosity volume fraction, lower and higher order nonlocal parameters, material characteristic parameter, foundations components, and wave number) on the wave propagation behaviors of porous FG nanoplates are investigated in detail.
Protein kinase WNK3 regulates the neuronal splicing factor Fox-1

We report an action of the protein kinase WNK3 on the neuronal mRNA splicing factor Fox-1. Fox-1 splices mRNAs encoding proteins important in synaptic transmission and membrane excitation. WNK3, implicated in the control of neuronal excitability through actions on ion transport, binds Fox-1 and inhibits its splicing activity in a kinase activity-dependent manner. Phosphorylation of Fox-1 by WNK3 does not change its RNA binding capacity; instead, WNK3 increases the cytoplasmic localization of Fox-1, thereby suppressing Fox-1–dependent splicing. These findings demonstrate a role of WNK3 in RNA processing. Considering the implication of WNK3 and Fox-1 in disorders of neuronal development such as autism, WNK3 may offer a target for treatment of Fox-1–induced disease.
Survey among critical care nurses and physicians about delirium management

BACKGROUND Delirium is a serious complication in patients in intensive care units. Previous surveys on delirium management in daily practice showed low adherence to published guidelines. AIM To evaluate delirium management in nurses and physicians working in intensive care units in German-speaking countries and to identify related differences between nurses and physicians. DESIGN The study used an open online survey with multiple-choice responses. METHODS An invitation for participation was spread via journals and electronic resources using a snowball system. Apart from recording socio-demographical characteristics, the survey collected data on delirium assessment, delirium-related processes, non-pharmacological prevention and treatment and barriers for implementation. Differences between nurses and physicians were tested by Fisher's exact test with sequential Bonferroni correction. RESULTS The survey was conducted in autumn 2016, and 559 clinicians participated. More nurses than physicians reported screening for delirium. The majority of clinicians reported screening for delirium when this was suspected; more than 50% used validated instruments. Half of the clinicians had delirium-related structures implemented, such as two thirds reporting delirium-related processes. Most cited barriers were lack of time and missing knowledge about delirium and its assessment. With significant difference, physicians recommended more than nurses early removal of catheters and daily interprofessional goals for patients. CONCLUSION In German-speaking countries, assessment of delirium needs further improvement, leading to accurate assessment. Delirium-related structures and processes appear to be implemented widely, with only a few differences between nurses and physicians. RELEVANCE TO CLINICAL PRACTICE Nurses and physicians in this survey reported similar perceptions and attitudes towards management of delirium. Both professions need more knowledge and inter-professional training on when and how to use validated assessment instruments.
Tumor Tracking Method Based on a Deformable 4 D CT Breathing Motion Model Driven by an External Surface

Tumor Tracking Method Based on a Deformable 4D CT Breathing Motion Model Driven by an External Surface Surrogate Aurora Fassi, PhD,* Joël Schaerer, PhD,y,z Mathieu Fernandes, PhD,y,z Marco Riboldi, PhD,*,x David Sarrut, PhD,y,z and Guido Baroni, PhD*,x *Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, Italy; yCREATIS, CNRS UMR 5220, INSERM U1044, Université Lyon 1, INSA-Lyon, Villeurbanne, France; zDepartment of Radiotherapy, Centre Léon Bérard, Lyon, France; and xBioengineering Unit, CNAO Foundation, Pavia, Italy
A Calcineurin-dependent Switch Controls the Trafficking Function of α-Arrestin Aly1/Art6*

Background: In response to nutrient signals, α-arrestins selectively regulate trafficking of membrane transporters. Results: Aly1 is a substrate of the phosphatase calcineurin, and dephosphorylation triggers Aly1-dependent internalization of the permease Dip5. Conclusion: Endocytic function of α-arrestins is stimulated by removal of inhibitory phosphorylation. Significance: These insights define a molecular mechanism controlling the function of an α-arrestin in endocytosis, which is critical for cellular adaptation. Proper regulation of plasma membrane protein endocytosis by external stimuli is required for cell growth and survival. In yeast, excess levels of certain nutrients induce endocytosis of the cognate permeases to prevent toxic accumulation of metabolites. The α-arrestins, a family of trafficking adaptors, stimulate ubiquitin-dependent and clathrin-mediated endocytosis by interacting with both a client permease and the ubiquitin ligase Rsp5. However, the molecular mechanisms that control α-arrestin function are not well understood. Here, we show that α-arrestin Aly1/Art6 is a phosphoprotein that specifically interacts with and is dephosphorylated by the Ca2+- and calmodulin-dependent phosphoprotein phosphatase calcineurin/PP2B. Dephosphorylation of Aly1 by calcineurin at a subset of phospho-sites is required for Aly1-mediated trafficking of the aspartic acid and glutamic acid transporter Dip5 to the vacuole, but it does not alter Rsp5 binding, ubiquitinylation, or stability of Aly1. In addition, dephosphorylation of Aly1 by calcineurin does not regulate the ability of Aly1 to promote the intracellular sorting of the general amino acid permease Gap1. These results suggest that phosphorylation of Aly1 inhibits its vacuolar trafficking function and, conversely, that dephosphorylation of Aly1 by calcineurin serves as a regulatory switch to promote Aly1-mediated trafficking to the vacuole.
How to Incorporate Eccentric Training Into a Resistance Training Program

ABSTRACT ECCENTRIC TRAINING AND ECCENTRIC MUSCULAR CONTRACTIONS FOCUS ON ACTIVE LENGTHENING WHILE LOADED. WHEN COMPARED WITH CONCENTRIC MOVEMENTS, ECCENTRIC ACTIONS YIELD GREATER FORCE LEVELS WITH CONCOMITANT LOWER NEUROMUSCULAR ACTIVATION LEVELS. ECCENTRIC TRAINING IS MAINLY INCORPORATED INDIRECTLY BY STRENGTH AND CONDITIONING AND FITNESS PROFESSIONALS LEADING TO IT BEING OFTEN UNDERUSED AND UNDERVALUED. ECCENTRIC TRAINING CAN READILY BE INCORPORATED INTO A TRAINING PROGRAM ALONG WITH THE USE OF NONTRADITIONAL EXERCISES FOR ALL POPULATIONS. THIS ARTICLE EXAMINES THE SCIENCE OF ECCENTRIC TRAINING AND EXTENDS THIS SCIENCE BY FOCUSING ON PRACTICAL RECOMMENDATIONS. SUGGESTED PROGRESSIONS ARE PROVIDED DEPENDING ON TRAINING BACKGROUND ALONG WITH CASE STUDY SCENARIOS.
Reduction in Exposure to Lead from Drinking Water and its Effect on Blood Lead Concentrations

1 The water supply in Ayr (Scotland, UK) was plumbosolvent and many dwellings in Ayr contained lead pipes. In 1981 treatment of the water supply to reduce its plumbosolvency was initiated. Measurements of water and blood lead concentrations were made before and subsequent to the treatment. Most of the measurements made before and after water treatment began were made on water samples from the same dwellings and blood samples from the same women. 2 Water treatment produced a sharp fall in water lead concentrations and a decrease in the median blood lead concentration from 21 to 13 μg/100 ml. 3 Two women had higher than expected blood lead concentrations, both these women had been removing old paint. 4 Women who had lead pipes removed from their dwellings all showed substantial decreases in their blood lead concentrations. 5 The curvilinearity of the relation between blood lead and water lead concentrations is confirmed. Even relatively low (<40 μg/l) water lead concentrations may make a substantial contribution to blood lead concentrations.
Rapid method for the detection of DNase of campylobacters

A rapid agar diffusion method for the detection of DNase production of Campylobacter jejuni, C. coli, and C. pylori was developed. A strong pink zone indicating DNA hydrolysis was seen around the wells after 20 to 24 h of aerobic incubation at 37 degrees C. Pretreatment of cells with polymyxin B, which releases the cell-associated DNase, both shortened the time needed to read positive results to 8 h and increased the zone size.
Image Enhancement of Routine Biopsies: A Case for Liver Tissue Detection

Analysis of histopathological images covers a wide field of clinical practice in different pathological conditions. In many cases, biopsy images from different sources share similar characteristics. In this work, a method for image enhancement of biopsy images is proposed. During the first stage, the quality of the image is optimized, while in the second stage, a clustering technique is employed to separate the tissue from the background. For the evaluation of the method, Liver biopsies which have been extracted for the staging of Hepatitis C, are employed. The methodology has been tested using 19 liver biopsy images from patients who suffer from hepatic fibrosis and steatosis, obtaining detection Accuracy over 97% in pixel level.
Periodontal regeneration with enamel matrix derivative in reconstructive periodontal therapy: a systematic review.

BACKGROUND Enamel matrix derivative (EMD) is commonly used in periodontal therapy. The aim of this systematic review is to give an updated answer to the question of whether the additional use of EMD in periodontal therapy is more effective compared with a control or other regenerative procedures. METHODS A literature search in MEDLINE (PubMed) for the use of EMD in periodontal treatment was performed up to May 2010. The use of EMD in treatment of intrabony defects, furcations, and recessions was evaluated. Only randomized controlled trials with ≥1 year of follow-up were included. The primary outcome variable for intrabony defects was the change in clinical attachment level (CAL), for furcations the change in horizontal furcation depth, and for recession complete root coverage. RESULTS After screening, 27 studies (20 for intrabony defects, one for furcation, and six for recession) were eligible for the review. A meta-analysis was performed for intrabony defects and recession. The treatment of intrabony defects with EMD showed a significant additional gain in CAL of 1.30 mm compared with open-flap debridement, EDTA, or placebo, but no significant difference compared with resorbable membranes was shown. The use of EMD in combination with a coronally advanced flap compared with a coronally advanced flap alone showed significantly more complete root coverage (odds ratio of 3.5), but compared with a connective tissue graft, the result was not significantly different. The use of EMD in furcations (2.6 ± 1.8 mm) gave significantly more improvement in horizontal defect depth compared with resorbable membranes (1.9 ± 1.4 mm) as shown in one study. CONCLUSIONS In the treatment of intrabony defects, the use of EMD is superior to control treatments but as effective as resorbable membranes. The additional use of EMD with a coronally advanced flap for recession coverage will give superior results compared with a control but is as effective as a connective tissue graft. The use of EMD in furcations will give more reduction in horizontal furcation defect depth compared with resorbable membranes.
Race and Beliefs About Mental Health Treatment Among Anxious Primary Care Patients

Abstract Large racial disparities in the use of mental health care persist. Differences in treatment preferences could partially explain the differences in care between minority and nonminority populations. We compared beliefs about mental illness and treatment preferences between adult African-Americans, Hispanics, Asian Americans, Native Americans, and White Americans with diagnosed anxiety disorders. Measures of beliefs about mental illness and treatment were drawn from the National Comorbidity Survey Replication and from our previous work. There were no significant differences in beliefs between the African-Americans and the White Americans. The beliefs of the Hispanics and the Native Americans were most distinctive, but the differences were small in magnitude. Across race/ethnicity, the associations between beliefs and service use were generally weak and statistically insignificant. The differences in illness beliefs and treatment preferences do not fully explain the large, persistent racial disparities in mental health care. Other crucial barriers to quality care exist in our health care system and our society as a whole.