Miracle-dz/UniFAR-FTUs huggingface dataset:
Overweight and waist circumference among Norwegian 11-year-olds and associations with reported parental overweight and waist circumference: The HEIA study

Aims: The aim of this paper is to investigate anthropometric characteristics in 11-year-old Norwegian by gender and parental education, and to study associations between adolescents’ overweight and waist circumference (WC) and maternal and paternal overweight and WC. Methods: A total of 1483 adolescents, 1156 mothers, and 1016 fathers participated in the baseline survey of the HEalth In Adolescents (HEIA) study (September 2007). Anthropometric measures of the adolescents were assessed by project staff according to standard procedures. Self-reported data about pubertal status were collected through questionnaires. Parental education and anthropometric measures of parents were collected by self-report. Results: The prevalence of overweight (including obesity) determined by the cut-offs for body mass index (BMI) suggested by the International Obesity Task Force was 14.6% among girls and 13.6% among boys. The highest prevalence of overweight was observed among adolescents with parents who had less than 12 years of education (18.8%). Overweight and WC in girls was strongly associated with maternal overweight and WC. For boys, overweight and WC was strongly associated with both maternal and paternal overweight and WC. Conclusions: There was a social gradient in anthropometric characteristics and overweight rates among Norwegian 11-year-old adolescents. Maternal overweight and WC was associated with overweight and WC in girls and boys, while paternal overweight and WC were associated with overweight and WC in boys. The results indicate that mothers are key persons in prevention of overweight among adolescents, despite gender. Fathers are important as role models for their sons. Targeting parental overweight/ obesity could be a strategy in future interventions.
Effect of metformin treatment on endometrial vascular indices in anovulatory obese/overweight women with polycystic ovarian syndrome using three‐dimensional power doppler ultrasonography

Metformin has been shown to be an effective treatment for anovulatory polycystic ovary syndrome (PCOS) patients in terms of menstrual cyclicity, ovulation, and pregnancy, as well as reduction of early miscarriage rate. The aim of the study is to assess the effect of metformin on the endometrial vascular indices in anovulatory obese PCOS women using three‐dimensional power Doppler sonography (3DPDUS).
Pressure Flow Analysis in the Assessment of Preswallow Pharyngeal Bolus Presence in Dysphagia

Objectives. Preswallow pharyngeal bolus presence is evident in patients with oropharyngeal dysphagia. Pressure flow analysis (PFA) using high resolution manometry with impedance (HRMI) with AIMplot software is a method for objective interpretation of pharyngeal and upper esophageal sphincter (UES) pressures and bolus flow patterns during swallowing. This study aimed to observe alterations in PFA metrics in the event of preswallow pharyngeal bolus presence as seen on videofluoroscopy (VFSS). Methods. Swallows from 40 broad dysphagia patients and 8 controls were recorded with a HRMI catheter during simultaneous VFSS. Evidence of bolus presence and level reached prior to pharyngeal swallow onset was recorded. AIMPlot software derived automated PFA functional metrics. Results. Patients with bolus movement to the pyriform sinuses had a higher SRI, indicating greater swallow dysfunction. Amongst individual metrics, TNadImp to PeakP was shorter and flow interval longer in patient groups compared to controls. A higher pharyngeal mean impedance and UES mean impedance differentiated the two patient groups. Conclusions. This pilot study identifies specific altered PFA metrics in patients demonstrating preswallow pharyngeal bolus presence to the pyriform sinuses. PFA metrics may be used to guide diagnosis and treatment of patients with oropharyngeal dysphagia and track changes in swallow function over time.
Radial kinematics of brightest cluster galaxies

This is the first of a series of papers devoted to the investigation of a large sample of brightest cluster galaxies (BCGs), their kinematic and stellar population properties, and the relationships between those and the properties of the cluster. We have obtained high signal-to-noise ratio, long-slit spectra of these galaxies with Gemini and William Herschel Telescope with the primary purpose of investigating their stellar population properties. This paper describes the selection methods and criteria used to compile a new sample of galaxies, concentrating on BCGs previously classified as containing a halo (cD galaxies), together with the observations and data reduction. Here, we present the full sample of galaxies, and the measurement and interpretation of the radial velocity and velocity dispersion profiles of 41 BCGs. We find clear rotation curves for a number of these giant galaxies. In particular, we find rapid rotation (>100 km s -1 ) for two BCGs, NGC 6034 and 7768, indicating that it is unlikely that they formed through dissipationless mergers. Velocity substructure in the form of kinematically decoupled cores is detected in 12 galaxies, and we find five galaxies with velocity dispersion increasing with radius. The amount of rotation, the velocity substructure and the position of BCGs on the anisotropy-luminosity diagram are very similar to those of 'ordinary' giant ellipticals in high-density environments.
Consumers in a Sustainable Food Supply Chain (COSUS): Understanding Consumer Behavior to Encourage Food Waste Reduction

Consumers are directly and indirectly responsible for a significant fraction of food waste which, for a large part, could be avoided if they were willing to accept food that is suboptimal, i.e., food that deviates in sensory characteristics (odd shape, discoloration), or that has a best-before date which is approaching or has passed, but that is still perfectly fine to eat. The choice to accept or discard suboptimal food is taken either before or after purchase (hence, in the retail store or in the household). The aim of the European research project COSUS (Consumers in a sustainable food supply chain) was to increase consumer acceptance of suboptimal food, before and after purchase, by implementing targeted strategies that are based on consumer insights, and that are feasible for and acceptable by the food sector. To reach this aim, different methodological approaches were applied to analyze this issue, to experiment with different aspects, and to test the resulting interventions. Each of these approaches was undertaken by competent consortium partners from Denmark, Germany, Norway, Sweden and The Netherlands. The project finally provides validated strategies to promote the distribution and consumption of suboptimal foods, thereby improving resource efficiency in the food chain and contributing to a more sustainable food supply.
Évaluations des caractéristiques émotionnelles d'un corpus de 604 mots

Dans ce travail, nous presentons une norme concernant la dimension emotionnelle de 604 mots, effectuee a partir d’une evaluation de la valence avec une echelle nominale a trois modalites (negatif, neutre et positif) et d’une evaluation de la valence combinee a l’intensite avec une echelle ordinale bipolaire relative en 11 points. Au total 600 participants ont participe a ces deux evaluations. Les classifications des mots obtenues a partir de ces deux types d’echelle different. Les mots classes comme etant indubitablement de valence positive ou negative dans la premiere evaluation ne sont pas pour autant tous classes parmi les mots les plus intenses dans la deuxieme evaluation. D’un autre cote, la prise en compte des resultats des deux evaluations est particulierement heuristique pour l’identification de mots reellement neutres. Ces deux evaluations viennent completer les normes sur la dimension emotionnelle deja existantes et devraient favoriser la manipulation experimentale de facteurs semantiques dans les recherches en psycholinguistique.
An Identity Based Key Management Scheme in Wireless Sensor Networks

Pairwise key establishment is one of the fundamental security services in sensor networks which enables sensor nodes in a sensor network to communicate securely with each other using cryptographic techniques. It is not feasible to apply traditional public key management techniques in resource-constrained sensor nodes, and also because the sensor nodes are vulnerable to physical capture. In this paper, we introduce a new scheme called the identity based key pre-distribution using a pseudo random function (IBPRF), which has better trade-off between communication overhead, network connectivity and resilience against node capture compared to the other key pre-distribution schemes. Our scheme can be easily adapted in mobile sensor networks. This scheme supports the addition of new sensor nodes after the initial deployment and also works for any deployment topology. In addition, we propose an improved version of our scheme to support large sensor networks.
The Mirages of Marriage.

The late Dr. Don D. Jackson and Mr. William Lederer have undertaken an ambitious project in The Mirages of Marriage . They have attempted to present a work on the marital relationship and its vicissitudes that would be of interest and value to a wide audience. This would include marital therapists from various disciplines, marital counselors, and marital couples concerned with their problems in marriage. Their success in this undertaking is a credit to their knowledge of the problems of marriage and their skill as writers. Dr. Jackson had done extensive work in the fields of human communications and family relationships. Mr. Lederer, the co-author of The Ugly American , became interested in the problems of marriage as a result of his study of systems theory at Harvard University, where he is writer-inresidence. Their collaboration has resulted in a "successful marriage. " The "Forward" by
THE EXPERIENCES OF ADOLESCENTS ORPHANED BY HIV/AIDS-RELATED CONDITIONS

The work environment of social workers in South Africa is riddled with new and complex social problems, often draining the available resources (Giese, Meintjes, Croke & Chamberlain, 2003:7). Personnel in rural areas are confronted with huge numbers of orphaned children in need of urgent statutory intervention, mostly because of the economic burden brought about by their “orphan” status. Very little time can be spent on the socio-emotional care of these children, as the emphasis largely falls on the provision of basic needs, such as grants, school uniforms and food.
Comparison of a mouse and a novel human scFv-SNAP-auristatin F drug conjugate with potent activity against EGFR-overexpressing human solid tumor cells

Antibody–drug conjugates (ADCs) can deliver toxins to specific targets such as tumor cells. They have shown promise in preclinical/clinical development but feature stoichiometrically undefined chemical linkages, and those based on full-size antibodies achieve only limited tumor penetration. SNAP-tag technology can overcome these challenges by conjugating benzylguanine-modified toxins to single-chain fragment variables (scFvs) with 1:1 stoichiometry while preserving antigen binding. Two (human and mouse) scFv-SNAP fusion proteins recognizing the epidermal growth factor receptor (EGFR) were expressed in HEK 293T cells. The purified fusion proteins were conjugated to auristatin F (AURIF). Binding activity was confirmed by flow cytometry/immunohistochemistry, and cytotoxic activity was confirmed by cell viability/apoptosis and cell cycle arrest assays, and a novel microtubule dynamics disassembly assay was performed. Both ADCs bound specifically to their target cells in vitro and ex vivo, indicating that the binding activity of the scFv-SNAP fusions was unaffected by conjugation to AURIF. Cytotoxic assays confirmed that the ADCs induced apoptosis and cell cycle arrest at nanomolar concentrations and microtubule disassembly. The SNAP-tag technology provides a platform for the development of novel ADCs with defined conjugation sites and stoichiometry. We achieved the stable and efficient linkage of AURIF to human or murine scFvs using the SNAP-tag technology, offering a strategy to improve the development of personalized medicines.
Computational Systems Biology in Cancer: Modeling Methods and Applications

In recent years it has become clear that carcinogenesis is a complex process, both at the molecular and cellular levels. Understanding the origins, growth and spread of cancer, therefore requires an integrated or system-wide approach. Computational systems biology is an emerging sub-discipline in systems biology that utilizes the wealth of data from genomic, proteomic and metabolomic studies to build computer simulations of intra and intercellular processes. Several useful descriptive and predictive models of the origin, growth and spread of cancers have been developed in an effort to better understand the disease and potential therapeutic approaches. In this review we describe and assess the practical and theoretical underpinnings of commonly-used modeling approaches, including ordinary and partial differential equations, petri nets, cellular automata, agent based models and hybrid systems. A number of computer-based formalisms have been implemented to improve the accessibility of the various approaches to researchers whose primary interest lies outside of model development. We discuss several of these and describe how they have led to novel insights into tumor genesis, growth, apoptosis, vascularization and therapy.
Exploring the Structure of Zuckerman's Sensation Seeking Scale, Form V in a Spanish Sample

The psychometric properties of the original version of the Sensation Seeking Scale (Form V) were analyzed in a sample of 1,006 Spanish university students. The total sample was randomly split into two halves. Exploratory factor analyses were conducted on the calibration sample (n = 504), whereas confirmatory factor analysis procedures were performed on the validation sample (n = 502). As previous studies have suggested, exploratory factor structure indicated that several items load on a different factor or have loadings lower than . 30. Those problems were surpassed when the best five items per factor were factor analyzed again. The confirmatory factor analyses showed that a 4-factor simple structure model gave a clearly imperfect fit. A model of 20 items (5 items per factor) gave a better fit, although with similar problems regarding the low reliabilities of the Experience Seeking and Boredom Susceptibility subscales. The need for improvement of the four-factor structure is discussed.
Fast Information Propagation in Social Networks

Social networks are attracting more attention from both industry and academia. Prior works on social networks focus on analyzing their roles in information propagation and decision making. However, few of these works consider the latency of information propagation, which is an essential issue especially in time-critical scenarios in social networks. In this paper, we introduce a new problem called FAST INFORMATION PROPAGATION PROBLEM, which is an optimization problem to identify the minimum set of influential nodes that could influence the whole network within a given latency bound d. We show our complexity result on this problem in the deterministic threshold models and present a greedy hill-climbing algorithm as the solution. For the d = 1 case, we prove that under the majority threshold model, this approximation algorithm has a performance ratio of H(Δ + 1) - 1 + ⌈ Δ/2⌉. Extensive experiments are conducted on a large collaboration network and the results show that our approximation algorithm outperforms the node-selection heuristics, which utilize the well-known approaches based on the node centrality in the social network analysis.
Organizational Identity

Organizational identity offers a theory and practice for analyzing the intersubjective meaning of organizational behavior. It advances an explanation of individual feelings about organizations rooted in infancy, what Winnicott (1965) calls a "holding environment," and an explanation of interpersonal relationships in adulthood but with origins in infancy and childhood, what Kohut (1977; 1984) calls "selfobject transferences. "It further presents the notion of transference of emotions in hierarchical organizations as an instrument for observing and explaining key interpersonal relationships between organizational super ordinates and subordinates, and between organizational analysts and clients. Knowing organizational identity provides an understanding of unconscious motivations governing the behavior of organizational members.
Like it or not: differences in advertising likeability and dislikeability within Asia

Purpose – The purpose of this paper is to examine Asian consumers' attitudes towards television advertisements (ads) to provide an insight into the antecedents and consequences of liked and disliked ads and the cultural differences that influence these relationships.Design/methodology/approach – A matched sample of young consumers from four Asian cities was asked to nominate ads that they both liked and disliked. They also provided reasons as to why they were liked and disliked and the effect this had on their purchase intentions. The results were analysed using multiple and logistic regression.Findings – Findings show that ad likeability increases if people feel that advertising provides something to talk about. Conversely, people who find advertising annoying have higher ratings of ad dislikeability. Results also show that a close relationship exists between liking (disliking) television ads and buying more (less) of the advertised products. However, differences exist between Asian cities.Practical impl.
Integrated Reliability-Assessment for Protein-Protein Interaction Data

Interaction among genes and gene products has a major role in many cellular processes. Obtaining an accurate picture of protein-protein interactions is one of the major challenges to the systematic understanding of cellular activity. While there are reliable but time-consuming experimental techniques to determine interactions, there have been developed a variety of high-throughput methods to obtain vast amounts of protein-protein interaction data at a time. With accumulation of high throughput protein-protein interaction data, evaluation of these data becomes of importance. Previous studies indicate that local connectivity pattern of interaction data can be used for measuring the reliability of individual interaction [3]. However, these approaches have one major drawback: they are excessively dependent upon connectivity patterns of interaction data which contain false negatives as well as false positives. Here we propose an integrated approach for reliability assessment of protein-protein interaction data from yeast two-hybrid system. Our approach uses both local connectivity pattern of interaction data and other information of each protein as attributes of individual interaction. Information of proteins includes cellular localization and function. Using these attributes, we employ decision tree as machine learning architecture. For evaluating this method, the yeast two-hybrid interaction data of Saccharomyces cerevisiae by Ito et al. (full data: 4549 interactions) [2] is used as an evaluation target and DIP-core is used as golden standard.
Effect of Islet-Activating Protein (IAP), Purified from the Culture Medium of Bordetella pertussis, on the Secretion of Immunoreactive Insulin and Glucagon in Normal, Alloxan-Treated, and Depancreatized Dogs

Islet-activating protein (IAP) is a new active substance purified from the culture medium of Bordetella pertussis. This active protein possesses a molecular weight of 77,000 and an isoelectric point of pH 7.8. The nature of IAP action is characterized by the enhancement of insulin secretory response to glucose and other stimuli. In this experiment, the effect of IAP on the secretion of immunoreactive insulin (IRI) and glucagon (IRG) was investigated in conscious normal, alloxan-treated, and depancreatized dogs. On the 8th day after IAP injection, in normal and alloxan-treated dogs during the infusion of arginine or glucose, the plasma glucose level was lower and the IRI level was significantly higher compared with the saline controls. The IRG level showed no significant difference between IAP and saline control groups of normal dogs, but in alloxan-treated dogs the IRG level was significantly lower when compared with the saline control. This effect of IAP disappeared on the 30th day after injection in normal and alloxan-treated dogs. However, in depancreatized dogs, there was no effect on plasma glucose and gastrointestinal IRG levels. Anti-IAP antibody was not detected by PHA before or after IAP injection in any dogs, although a marked increase of heart rate was observed. These findings suggest that (1) IAP had an insulinotropic effect in dogs, (2) insulin deficiency induced by alloxan was partially overcome by IAP, (3) the effect of IAP on glucagon secretion might be secondarily related to the enhancement of insulin secretion, although a direct glucagon-lowering effect in alloxan-treated dogs could not be excluded, (4) a single administration of IAP did not produce anti-IAP antibody, and (5) an increase of heart rate was observed after IAP injection.
A recA Null Mutation May Be Generated in Streptomyces coelicolor

ABSTRACT The recombinase RecA plays a crucial role in homologous recombination and the SOS response in bacteria. Although recA mutants usually are defective in homologous recombination and grow poorly, they nevertheless can be isolated in almost all bacteria. Previously, considerable difficulties were experienced by several laboratories in generating recA null mutations in Streptomyces, and the only recA null mutants isolated (from Streptomyces lividans) appeared to be accompanied by a suppressing mutation. Using gene replacement mediated by Escherichia coli-Streptomyces conjugation, we generated recA null mutations in a series of Streptomyces coelicolor A3(2) strains. These recA mutants were very sensitive to mitomycin C but only moderately sensitive to UV irradiation, and the UV survival curves showed wide shoulders, reflecting the presence of a recA-independent repair pathway. The mutants segregated minute colonies with low viability during growth and produced more anucleate spores than the wild type. Some crosses between pairs of recA null mutants generated no detectable recombinants, showing for the first time that conjugal recombination in S. coelicolor is recA mediated, but other mutants retained the ability to undergo recombination. The nature of this novel recombination activity is unknown.
Architecture of EHARP Routing Protocols in Ad Hoc Wireless Networks

Ad hoc wireless networks consist of a number of nodes roaming freely, interconnecting with each other by wireless connection without relying on a predefined infrastructure. When comparing ad hoc wireless networks with fixed networks or infrastructure wireless networks, ad hoc wireless networks base on the nodes that work as host and as router. In this paper, we present a new routing protocol for an ad hoc wireless network which is called Enhanced Heading direction Angle Routing Protocol (EHARP). It base on counter of the stability of link (SL) and acknowledge message to provide stability and availability of the network along select route path.