Miracle-dz/UniFAR-FTUs huggingface dataset:
Expressional control of the ‘constitutive’ isoforms of nitric oxide synthase (NOS I and NOS III)

Nitric oxide synthase (NOS) exists in three established isoforms. NOS I (NOS1, ncNOS) was originally discovered in neurons. This enzyme and splice variants thereof have since been found in many other cells and tissues. NOS II (NOS2, iNOS) was first identified in murine macrophages, but can also be induced in many other cell types. NOS III (NOS3, ecNOS) is expressed mainly in endothelial cells. Whereas NOS II is a transcriptionally regulated enzyme, NOS I and NOS III are considered constitutively expressed proteins. However, evidence generated in recent years indicates that these two isoforms are also subject to expressional regulation. In view of the important biological functions of these isoforms, changes in their expression may have physiological and pathophysiological consequences. This review recapitulates compounds and conditions that modulate the expression of NOS I and NOS III, summarizes transcriptional and posttranscriptional effects that underlie these changes, and—where known—describes the molecular mechanisms leading to changes in transcription, RNA stability, or translation of these enzymes. —Förstermann, U. , Boissel, J.‐P., Kleinert, H. Expressional control of the ‘constitutive’ isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J. 12, 773–790 (1998)
Latency-rate servers: a general model for analysis of traffic scheduling algorithms

In this paper, we develop a general model, called latency-rate servers (LR-servers), for the analysis of traffic scheduling algorithms in broadband packet networks. The behavior of an LR scheduler is determined by two parameters-the latency and the allocated rate. We show that several well-known scheduling algorithms, such as weighted fair queueing, virtualclock, self-clocked fair queueing, weighted round robin, and deficit round robin, belong to the class of LR-servers. We derive tight upper bounds on the end-to-end delay, internal burstiness, and buffer requirements of individual sessions in an arbitrary network of LR-servers in terms of the latencies of the individual schedulers in the network, when the session traffic is shaped by a leaky bucket. Thus, the theory of LR-servers enables computation of tight upper-bounds on end-to-end delay and buffer requirements in a network of servers in which the servers on a path may not all use the same scheduling algorithm. We also define a self-contained approach to evaluate the fairness of LR-servers and use it to compare the fairness of many well-known scheduling algorithms.
A Neural-Learning-Algorithm-Based Shape from Shading System

This paper introduces a shape from shading (SFS) system, which is based on a neural learning algorithm. The system takes a single image of an object with a CCD camera and then reconstructs the object surface with a neural-learning-based SFS algorithm. This SFS algorithm solves and optimizes the neural elements, named network weights, by minimizing the cost function that is composed of the intensity constraint and the integrability constraint. This neural-learning-based SFS algorithm can provide a promising effectiveness and accuracy. Moreover, the reconstructed surface of this system can be applied in the area of surface measurement and defect detection
Zebrafish Thsd7a is a neural protein required for angiogenic patterning during development

Angiogenesis is a highly organized process under the control of guidance cues that direct endothelial cell (EC) migration. Recently, many molecules that were initially described as regulators of neural guidance were subsequently shown to also direct EC migration. Here, we report a novel protein, thrombospondin type I domain containing 7A (Thsd7a), that is a neural molecule required for directed EC migration during embryonic angiogenesis in zebrafish. Thsd7a is a vertebrate conserved protein. Zebrafish thsd7a transcript was detected along the ventral edge of the neural tube in the developing zebrafish embryos, correlating with the growth path of angiogenic intersegmental vessels (ISVs). Morpholino‐knockdown of Thsd7a caused a lateral deviation of angiogenic ECs below the thsd7a‐expressing sites, resulting in aberrant ISV patterning. Collectively, our study shows that zebrafish Thsd7a is a neural protein required for ISV angiogenesis, and suggests an important role of Thsd7a in the neurovascular interaction during zebrafish development. Developmental Dynamics 240:1412–1421, 2011. © 2011 Wiley‐Liss, Inc.
Crystal structure of 1-methoxy-2,2,2-tris(pyrazol-1-yl)ethane

The title compound, C12H14N6O, consists of three pyrazole rings bound via nitrogen to the distal ethane carbon of methoxy ethane. The dihedral angles between the three pyrazole rings are 67.62 (14), 73.74 (14), and 78.92 (12)°. In the crystal, molecules are linked by bifurcated C—H,H⋯N hydrogen bonds, forming double-stranded chains along [001]. The chains are linked via C—H⋯O hydrogen bonds, forming a three-dimensional framework structure. The crystal was refined as a perfect (0.5:0.5) inversion twin.
FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

Fas-associated death domain protein (FADD) and caspase-8 (casp8) are vital intermediaries in apoptotic signaling induced by tumor necrosis factor family ligands. Paradoxically, lymphocytes lacking FADD or casp8 fail to undergo normal clonal expansion following antigen receptor cross-linking and succumb to caspase-independent cell death upon activation. Here we show that T cells lacking FADD or casp8 activity are subject to hyperactive autophagic signaling and subvert a cellular survival mechanism into a potent death process. T cell autophagy, enhanced by mitogenic signaling, recruits casp8 through interaction with FADD:Atg5-Atg12 complexes. Inhibition of autophagic signaling with 3-methyladenine, dominant-negative Vps34, or Atg7 shRNA rescued T cells expressing a dominant-negative FADD protein. The necroptosis inhibitor Nec-1, which blocks receptor interacting protein kinase 1 (RIP kinase 1), also completely rescued T cells lacking FADD or casp8 activity. Thus, while autophagy is necessary for rapid T cell proliferation, our findings suggest that FADD and casp8 form a feedback loop to limit autophagy and prevent this salvage pathway from inducing RIPK1-dependent necroptotic cell death. Thus, linkage of FADD and casp8 to autophagic signaling intermediates is essential for rapid T cell clonal expansion and may normally serve to promote caspase-dependent apoptosis under hyperautophagic conditions, thereby averting necrosis and inflammation in vivo.
II. the Phenomenology of Childhood Psychoses

This paper analyses the clinical picture in 80 children referred to the Park Hospital, Oxford, or to the Newcastle department of child psychiatry, and admitted for intensive assessment of their psychosis. All were seen by two psychiatrists and nearly three quarters of them in Oxford. The diagnostic criteria, and the differentiation by age of onset into infantile psychosis (I.P.) and late onset psychosis (L.O.P.) were discussed in the previous paper (Kolvin, I).
Comparison of the PPMXL and UCAC5 Catalogs with the Gaia DR2

Astrometric ground-based catalogs usually suffer from varied systematic errors. These systematic errors were hard to detect because there was no independent reference catalog complete to very faint limiting magnitudes (∼20 mag). This situation has changed since the second data release of the Gaia mission (Gaia DR2). We aim to investigate positions and the proper-motion (PM) system of two ground-based catalogs, the UCAC5 and PPMXL, referring to the Gaia DR2. The individual position in the Gaia DR2 is transferred by its PM to the epoch of other catalogs for comparison. Systematic errors that depend on the magnitude, color, and sky regions in the UCAC5 and PPMXL could be clearly seen. A different behavior between the northern and southern sky is found in the PPMXL, which is possibly inherited from the imperfect calibration of the PM system. Besides, we perform a quantitative analysis of global differences for positions and PMs by the vector spherical harmonics method in terms of 3 rotation angles, 3 glide parameters, and 10 quadrupole parameters. We find a large glide component of ∼8 mas along Z-axis and a rotation angle of ∼5 mas about Z-axis for positional offsets between the PPMXL and Gaia DR2. These terms are found to be insignificant between the UCAC5 and Gaia DR2. We show that the position and PM system of the UCAC5, a new reduction of ground-based observations in the frame of the Gaia reference system, has been largely improved. This indicates that systematic errors in positions and PMs obtained from ground-based observations are mostly impacted by a relatively poor reference catalog. But these observations can be reconstructed in the frame of a space-based reference catalog. In this sense, our results justify the tradition of space-calibrated ground-based astrometric catalogs.
Challenges and Solutions of Cyber-Physical Systems

Cyber physical systems(CPS) include a lot of high complexity computing such as dynamic analysis and verification of continuous dynamic property , analysis and verification of real-time property, analysis and verification of spatial property, scheduling and fault tolerance. The correctness of computing results of cyber physical systems not only meets the time requirements, but also meets the spatial requirement, this make that it is impossible to solve the several difficult computing problems by traditional methods. In this paper, we describe some of the research directions that we are taking toward addressing some of the challenges involved in building cyber physical systems. The ultimate goal is to develop foundations and techniques for building safe and effective cyber physical systems.
Analysis of Timed Automata with Guards in dioids algebra

In this paper, we propose a new linear representation to model the behavior of Timed Automata with Guards (TAGs) using the formalism of dioids algebra. This linear modeling is used to define the parallel composition and properties of determinism for TAGs. The contribution is illustrated with an example of a jobshop to analyze the performances of this system.
Loss Analysis and Engineering of Spoof Surface Plasmons Based on Circuit Topology

We propose to systematically investigate the loss mechanism in spoof surface plasmon transmission lines (SSP-TLs) associated with surface-mounted resistors, by numerical simulation and circuit topology modeling, with the experimental validations. Distorted dispersion and loss curves introduced by the resistors are simultaneously predicted by the numerical results and interpreted by the circuit topology model. Attenuators constructed by periodically loaded resistors and T-type networks are designed according to the circuit topology model, and validated by both simulation and experiment results; hence, significant and controllable losses are achieved in a deep-subwavelength scale. The proposed structures and methods enable insightful understanding of the SSP-TLs and hold promise in other lossy SSP device study and design.
Effective embeddings into strong degree structures

We show that any partial order with a Σ3 enumeration can be effectively embedded into any partial order obtained by imposing a strong reducibility such as ≤tt on the c. e. sets. As a consequence, we obtain that the partial orders that result from imposing a strong reducibility on the sets in a level of the Ershov hiearchy below ω + 1 are co‐embeddable.
Error Correction for Non-Abelian Topological Quantum Computation

The possibility of quantum computation using non-Abelian anyons has been considered for over a decade. However, the question of how to obtain and process information about what errors have occurred in order to negate their effects has not yet been considered. This is in stark contrast with quantum computation proposals for Abelian anyons, for which decoding algorithms have been tailor-made for many topological error-correcting codes and error models. Here, we address this issue by considering the properties of non-Abelian error correction, in general. We also choose a specific anyon model and error model to probe the problem in more detail. The anyon model is the charge submodel of D(S-3). This shares many properties with important models such as the Fibonacci anyons, making our method more generally applicable. The error model is a straight forward generalization of those used in the case of Abelian anyons for initial benchmarking of error correction methods. It is found that error correction is possible under a threshold value of 7% for the total probability of an error on each physical spin. This is remarkably comparable with the thresholds for Abelian models.
Target-dependent T-cell Activation by Coligation With a PSMA×CD3 Diabody Induces Lysis of Prostate Cancer Cells

Recently, we have described a bispecific PSMA×CD3 diabody with one binding site for the T-cell antigen receptor (TCR-CD3) and another for the Prostate Specific Membrane Antigen (PSMA). It effectively eliminates human prostate cancer cells by redirecting T-lymphocytes in vitro and in vivo. Here, we show that activation of the T-cells and killing of the tumor cells, only occurred when the T-cells were coincubated with PSMA-positive tumor cells and the PSMA×CD3 diabody. Both CD4+ and CD8+ human T-lymphocytes were activated. Surprisingly, they were equally potent in their cytotoxic activity, proliferation, and up-regulation of activation markers. Both, CD4+, and CD8+ T-cells mainly used the perforin-granzyme– based pathway and to a somewhat lesser extent the FasL pathway to lyse tumor cells. When Jurkat T-cells were stimulated with the diabody alone, the TCR-CD3 was not triggered. In contrast, when the diabody was clustered with a secondary antibody the TCR-CD3 was stimulated as detected by Ca2+-influx and Erk, IκB, and linker of activated T-cell phosphorylation. Clustering of the diabody could also be achieved by the dimeric PSMA antigen expressed on tumor cells. Thus, although the diabody binds to all T-cells, only those in contact with PSMA-expressing cancer cells are activated. In conclusion, the PSMA×CD3 diabody is suitable for a controlled polyclonal T-cell therapy of prostate cancer.
Current practice and clinical relevance of somatosensory assessment after stroke

Objective: To examine the perceived clinical relevance, current practice and knowledge of somatosensory testing in three professional groups involved in the management and rehabilitation of stroke. Design: Structured postal questionnaire sent to therapists and doctors. Subjects: One hundred and eighty occupational therapists from the National Association of Neurological Occupational Therapists (NANOT), 180 physiotherapists from the Association of Chartered Physiotherapists with an Interest in Neurology (ACPIN) and 360 doctors from the Association of British Neurologists (ABN) and the British Geriatrics Society (BSG). Setting: Hospitals and rehabilitation centres in the UK. Results: Replies were obtained from 84 occupational therapists (47%), 98 physiotherapists (55%) and 78 doctors (22%). Sixty-four occupational therapists (77%), 82 physiotherapists (84%) and 66 doctors (87%) indicated that they routinely performed somatosensory assessment as part of their clinical assessment. The two most commonly used measures were proprioception and light touch. Seventy-eight occupational therapists (93%), 88 physiotherapists (90%) and 67 doctors (91%) regarded sensory assessment as clinically significant in determining prognosis after stroke. Conclusions: Despite published reservations concerning its usefulness and reliability, most therapists and doctors routinely assess somatosensory loss after stroke. All three professions agreed that somatosensory testing presented useful information for prognosis. Furthermore, all professional groups believe somatosensory assessment to be clinically relevant.
The Relationship of Fear and Fatalism with Breast Cancer Screening Among a Selected Target Population of African American Middle Class Women

The purpose of this quantitative study was to explore whether fear and fatalism influence compliance with breast cancer screening among members of a selected target population of African American middle-class (AAMC) women. Using a cross-sectional analysis, a sample of 120 AAMC women, ages 35 and older, residing in Minnesota, was surveyed with an abridged version of the Champion Health Belief Model Scale (Champion, 1999), the Champion Breast Cancer Fear Scale (Champion et al, 2004), and an adapted version of the Powe Fatalism Model (Powe, 1995). Results indicated that fear and fatalism belief scores were statistically related to breast cancer compliance (p < .001). These barriers suggest a greater need for health interventions that are culturally specific, with the intention of improving the psychological aspects of health to address fear and fatalism. The social dimension of this change should involve building cohesive physician-patient relationships. This action serves to counteract fear, fatalism, and negativism, and to increase the level of comfort among individuals who are more apprehensive about seeking health care services.
Influenza Virion-Derived Viral Ribonucleoproteins Synthesize both mRNA and cRNA In Vitro

ABSTRACT The mechanisms regulating the synthesis of mRNA, cRNA, and viral genomic RNA (vRNA) by the influenza A virus RNA-dependent RNA polymerase are not fully understood. Early results suggested that the RNA polymerase “switched” from a transcriptase to a replicase during the viral life cycle in response to the expression of viral proteins. However, recently an alternative model suggesting that replication of influenza virus is regulated by stabilization of the replicative intermediates was proposed. According to this model, the virion-associated polymerase is capable of synthesizing both mRNA and cRNA. We now demonstrate that virion-derived viral ribonucleoproteins (vvRNPs) synthesize both mRNA and cRNA in vitro in the absence of non-virion-associated RNA polymerase or nucleoproteins. The authenticity of the in vitro-transcribed mRNA and cRNA was confirmed by terminal sequence analysis. The addition of non-virion-associated polymerase or NP had no effect on vvRNP activity. De novo synthesis of cRNA was found to be more sensitive than the capped primer-dependent synthesis of mRNA to the concentration of ATP, CTP, and GTP. We conclude that vvRNPs intrinsically possess both transcriptase and replicase activities and that there is no switch in the synthesis of mRNA to cRNA during the influenza virus life cycle.
Technical and Physical Activities of Small-Sided Games in Young Korean Soccer Players

Abstract Joo, CH, Hwang-Bo, K, and Jee, H. Technical and physical activities of small-sided games in young Korean soccer players. J Strength Cond Res 30(8): 2164–2173, 2016—The aim of this study was to examine the technical aspects and physical demands during small-sided games (SSGs) with different sized pitches in young Korean soccer players. Participants were randomly selected during a nationally held youth competition. Three different game formats were used: SSG8 (8 vs. 8 played on a small-sized field [68 × 47 m]), RSG8 (8 vs. 8 played on a regular-sized field [75 × 47 m]), and RSG11 (11 vs. 11 played on a regular-sized field). Eleven technical (ball touches, passes, and shots) and 6 physical demand variables (exercise frequency by intensity) were observed and analyzed. Same variables were also analyzed for the goalkeepers. As a result, SSG8 and RSG8 showed significantly greater numbers of technical plays in 5 and 4 variables in comparison to RSG11, respectively. In addition, although the exercise intensities increased slightly in both SSG formats, the amount was within the similar range as previous reports. In conclusion, the SSGs with reduced number of players may be referred in young players to effectively train them in technical aspects of the game by allowing greater ball exposure time without excessive physical demands. Various confounding factors such as pitch dimension should be carefully considered for training specific technical and physical variables in young Korean players.
Effectiveness of Self-Generation During Learning is Dependent on Individual Differences in Need for Cognition.

Self-generated information is better recognized and recalled than read information. This so-called generation effecthas been replicated several times for different types of stimulus material, different generation tasks, and retention intervals. The present study investigated the impact of individual differences in learners’ disposition to engage in effortful cognitive activities (need for cognition, NFC) on the effectiveness of self-generation during learning. Learners low in NFC usually avoid getting engaged in cognitively demanding activities. However, if these learners are explicitly instructed to use elaborate learning strategies such as self-generation, they should benefit more from such strategies than learners high in NFC, because self-generation stimulates cognitive processes that learners low in NFC usually tend not to engage in spontaneously. Using a classical word-generation paradigm, we not only replicated the generation effect in free and cued recall but showed that the magnitude of the generation effect increased with decreasing NFC in cued recall. Results are consistent with our assumption that learners higher in NFC engage in elaborate processing even without explicit instruction, whereas learners lower in NFC usually avoid cognitively demanding activities. These learners need cognitively demanding tasks that require them to switch from shallow to elaborate processing to improve learning. We conclude that self-generation is beneficial regardless of the NFC level, but our study extends the existing literature on the generation effect and on NFC by showing that self-generation can be particularly useful for balancing the learning disadvantage of students lower in NFC.
Agents of Diffusion - Insights from a Survey of Facebook Users

In times of web 2.0 and its strong focus on user interaction in business models, entrepreneurs and investors of internet businesses often back up their ambitious growth expectations with the argument of viral distribution. However, there exists little evidence on the determinants of consumers' willingness to voluntarily and actively exchange information about internet applications. Based on survey data of 475 Facebook users, this paper makes a contribution to fill this gap. Key findings are that passive (observation of other users) and active (purposeful recommendations from peers) viral channels are equally important to make users aware of a novel product. Active viral channels, however, dominate in convincing users to actually start using a product or service. We also find that users are altruistically motivated to recommend applications and predominantly use built-in invitation mechanisms in the application as a communication channel for recommendations. This paper contributes to the field of electronic marketing in two ways. First and foremost it brings forward empirical evidence on the interpersonal aspects of the mechanisms behind viral distribution and word-of-mouth marketing. Second, it presents the illustrative case of Facebook which has become a fore-runner in online marketing when it comes to taking into account user interaction and behavior.