Miracle-dz/UniFAR-FTUs huggingface dataset:
De novo 1q32q44 duplication and distal 1q trisomy syndrome

We report on an infant with minor anomalies and a de novo 1q duplication. The chromosomal abnormality was diagnosed prenatally after sonographic detection of cerebral ventriculomegaly and bilateral choroid plexus cysts in the fetus. The amniocentesis showed an abnormal male karyotype, 46,XY,dup(1)(q32q44), subsequently confirmed by fluorescence in situ hybridization using whole chromosome paint 1 and comparative genomic hybridization. The baby, born at 37 weeks of gestation, had wide cranial sutures and large fontanelles, sloping forehead, hypertelorism, short and downward‐slanting palpebral fissures, a high‐arched and narrow palate, malformed ears, and long feet with overriding second and third toes. This is the sixth case of known duplication involving the 1q32q44 segment; the physical findings in the case reported herein are similar to those of other patients reported previously, providing further evidence of the existence of the “distal 1q trisomy” phenotype. © 2003 Wiley‐Liss, Inc.
Correlation between white matter damage and gray matter lesions in multiple sclerosis patients

We observed the characteristics of white matter fibers and gray matter in multiple sclerosis patients, to identify changes in diffusion tensor imaging fractional anisotropy values following white matter fiber injury. We analyzed the correlation between fractional anisotropy values and changes in whole-brain gray matter volume. The participants included 20 patients with relapsing-remitting multiple sclerosis and 20 healthy volunteers as controls. All subjects underwent head magnetic resonance imaging and diffusion tensor imaging. Our results revealed that fractional anisotropy values decreased and gray matter volumes were reduced in the genu and splenium of corpus callosum, left anterior thalamic radiation, hippocampus, uncinate fasciculus, right corticospinal tract, bilateral cingulate gyri, and inferior longitudinal fasciculus in multiple sclerosis patients. Gray matter volumes were significantly different between the two groups in the right frontal lobe (superior frontal, middle frontal, precentral, and orbital gyri), right parietal lobe (postcentral and inferior parietal gyri), right temporal lobe (caudate nucleus), right occipital lobe (middle occipital gyrus), right insula, right parahippocampal gyrus, and left cingulate gyrus. The voxel sizes of atrophic gray matter positively correlated with fractional anisotropy values in white matter association fibers in the patient group. These findings suggest that white matter fiber bundles are extensively injured in multiple sclerosis patients. The main areas of gray matter atrophy in multiple sclerosis are the frontal lobe, parietal lobe, caudate nucleus, parahippocampal gyrus, and cingulate gyrus. Gray matter atrophy is strongly associated with white matter injury in multiple sclerosis patients, particularly with injury to association fibers.
Simultaneous extraction and derivatization of carbohydrates from green plant tissues for analysis by gas-liquid chromatography.

Simultaneous extraction and derivatization of carbohydrates was performed by mixing dry ground plant tissue with derivatization reagents in pyridine; trimethylsilyl derivatives were analyzed by gas-liquid chromatography. This "direct analysis" was compared to analysis of samples prepared by exhaustive ethanol extraction of the same ground plant tissues. Comparisons included leaf blades from apple, grape, corn, and tomato and leaf blade, petiole, stem, and pod tissues from soybean plants. Direct analysis gave superior quantification of sucrose, glucose, and fructose because of sucrose hydrolysis during ethanol extraction. Sucrose hydrolysis was highly variable among plant species and use of hot ethanol at the first extraction step reduced sucrose hydrolysis but did not always abolish it. Sucrose hydrolysis was probably due to the activity of hydrolytic enzymes in 75% ethanol at room temperature. Direct analysis was inferior for the quantification of cyclitols in the fibrous tissues of soybean but provided acceptable results for cyclitol analysis in leaf blade tissue. When the time for extraction/reaction was extended from 40 to 60 min, some improvement in recovery of cyclitols was observed, but recovery remained 10 to 20% below that obtained with exhaustive ethanol extraction. Mannitol was vacuum infiltrated into the five types of leaf tissue and recovery averaged 100% by the direct method relative to ETOH extraction for apple, grape, corn, and soybean leaves but was only 76% for tomato leaves. Direct analysis provides very large time savings and is clearly the method of choice when the analysis of large numbers of samples of plant tissues for carbohydrate composition is required.
Extending Local passivity Theory and Hopf bifurcation at the Edge of Chaos in Oregonator CNN

The fundamental local passivity theory asserts that a wide spectrum of complex behaviors may exist if the cells in the reaction–diffusion are not locally passive. This local passivity principle has provided a powerful tool for studying the complexity in a homogeneous lattice formed by coupled cells. In this paper, the complexity matrix YQ(s), which is the tool for testing the local passivity theory, is modified based on the characteristic polynomial AQ(λ). Then, the local passivity theory is applied to the study of the Oregonator CNN to judge if the cell parameters of a CNN are chosen at the edge of chaos. Analysis of the bifurcation and the numerical simulations show that nonzero diffusion term in Oregonator CNN may cause a reaction–diffusion equation oscillating under the appropriate choice of diffusion coefficient if the local passivity theory is not satisfied. That is, if the cell parameters of a CNN are chosen at the edge of chaos, the system is potentially unstable.
Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons

Vitamin A‐derived retinoic acids (RAs) are known to exert a variety of biological actions, including modulatory effects on cell differentiation and apoptosis. A recent study has demonstrated that 13‐cis‐RA and all‐trans‐RA suppressed neurogenesis in the dentate gyrus of the hippocampus in adult mice. The present experiments were performed to see whether 13‐cis‐RA and all‐trans‐RA could alter the dendritic morphology of cultured hippocampal neurons via RA receptors: retinoic acid receptor (RAR) and retinoid X receptor (RXR). High doses of 13‐cis‐RA and all‐trans‐RA exerted a negative effect on the cultured hippocampal neurons, while a low dose of 13‐cis‐RA but not all‐trans‐RA caused a positive effect. The negative changes induced by 13‐cis‐RA and all‐trans‐RA were antagonized by RXR antagonists and RAR antagonists, respectively. The positive changes induced by a low dose of 13‐cis‐RA were blocked by both RXR antagonists and RAR antagonists. These results suggest that RAs at high concentrations cause a negative effect on the dendritic morphology of cultured hippocampal neurons through RA receptors, while RAs at low concentrations exert a positive influence on cultured hippocampal neurons.
Implementation and normalization process of asynchronous video interviewing practices in the hospitality industry

Purpose Asynchronous video interviews (AVIs) enable recruiters and job candidates to conduct and review employment interviews at different points in time, promising improved cost and time efficiencies for all users. This research aims to investigate the implementation and normalization process of AVI in the hospitality industry with the unified theory of acceptance and use of technology (UTAUT) and the normalization process theory (NPT) providing theoretical support. Design/methodology/approach Semi-structured interviews have been conducted with hiring managers from three different hospitality companies, which were in different stages of the implementation process. The data have been recorded, transcribed and coded according to the UTAUT and NPT constructs, revealing emergent themes. Findings Five overarching themes emerged: AVI effort and efficiency expectation; augmentation to the interview process; challenges for the applicant; challenges for the recruiter; and issues with applicant interviewing aesthetics. Additional coding and analysis with NPT identified the following in terms of evaluation of the implementation process: participants’ implementation activities showed a tendency to emanate from cognitive participation (relationship work), leading to coherence (sense-making work), followed by collective action (enactment of work/operational work) and finally reflexive monitoring (appraisal work). Practical implications Findings from this research include recommendations for the best practices integrating AVI into the hospitality employee selection process. Originality/value Given the increased demands on the recruitment and selection of talent in the hospitality industry, several organizations have turned to mechanized HR software platforms. The impact of interview modalities and particularly AVI has received limited research attention, thus this study expanded this new stream of literature. Furthermore, this research is among a nascent stream using NPT to evaluate the implementation and normalization of this new technology.
Adopting the Principles of Universal Design into International and Global Studies’ Programs and Curriculum

The ideals of universal design have profoundly impacted instruction, policy, and infrastructure in course architecture and design within elementary education and at some universities. Within international and global studies, however, these principles have not deeply affected either pedagogy or scholarship despite the fact that classes in international studies may include more international students and third culture kids 1 than classes in other programs. Instead, in North America (as well as in much of Latin America and Europe), the current pedagogical model calls for students either to develop strategies on their own to succeed in class or to self-identify with documented disabilities if they need particular assistance or accommodation. This approach relies on a banking model for education, which does not focus upon learner agency. This paper argues that by adopting three principles—learner autonomy, the negotiated syllabus, and universal design—international and global studies programs can better meet the needs of diverse learners and reflect the field’s commitment to inclusion and social justice.
Role of myosin phosphorylation and [Ca2+]i in myogenic reactivity and arteriolar tone.

The aim of this study was to define the relationship between intraluminal pressure, intracellular calcium concentration ([Ca2+]i), and myosin light-chain (MLC) phosphorylation in isolated arterioles exhibiting myogenic tone. Cremaster muscles were removed from anesthetized rats, and arterioles (approximately 100-microns diam) were dissected from surrounding tissues and cannulated on glass pipettes. Vessels were warmed to 34 degrees C and initially pressurized to 70 mmHg in the absence of intraluminal flow. For [Ca2+]i measurements, vessels were loaded with 5 microM fura 2, and fluorescence emitted by excitation at 340 and 380 nm was measured. Data were considered in terms of changes in the fluorescence ratio (340/380 nm) and collected at steady-state intraluminal pressures between 30 and 170 mmHg. For measurement of MLC phosphorylation, vessels were frozen in acetone-dry ice followed by sonication in homogenizing buffer. Homogenates were separated by two-dimensional gel electrophoresis, and proteins were visualized by silver staining. MLC phosphorylation was quantitated photodensitometrically, and results are expressed as percent total 20-kDa MLC. Increasing intraluminal pressure resultedin significant constriction with increased [Ca2+]i and MLC phosphorylation. For example, the fluorescence ratio was 0.80 +/- 0.04 at 30 mmHg compared with 1.02 +/- 0.05 at 120 mmHg (n = 7 vessels); corresponding MLC-phosphorylation values were 27.7 +/- 1.6 and 39.6 +/- 3.0% (n = 6). MLC phosphorylation in arterioles superfused with 0 mM Ca(2+)-2 mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) was 8.5 +/- 0.7%. (ABSTRACT TRUNCATED AT 250 WORDS)
On achievable secrecy rate by noise aggregation over wireless fading channels

Noise aggregation is an efficient way of aggregating the inherent noises introduced during wireless transmissions over multiple channels to degrade the eavesdropper's channel quality. While the performance of channel aggregation has not been thoroughly studied over wireless fading channels, we in this paper concentrating on analyses of its achievable average secrecy rate with emphasis on binary symmetric channel (BSC), whose cross-over probability is a time-varying process. The advantage of noise aggregation over traditional transmission in fading environments is demonstrated by our analyses and simulations. Simulation results show that the noise aggregation scheme can achieve a remarkable increase in terms of average secrecy rate even if the eavesdropper has better average channel quality than the legitimate receiver.
Dispersion Analysis of 2-D Glide-Symmetric Corrugated Metasurfaces Using Mode-Matching Technique

In this letter, wave propagation in 2-D doubled corrugated metasurfaces, including glide-symmetric corrugated metasurfaces, embedded in a thin parallel plate waveguide have been analyzed using the mode matching method. The general dispersion equation for propagation at different directions is derived and dispersion surfaces have been obtained for three different cases. The results are in good agreement with reference results obtained using CST Microwave Studio. Moreover, the method is accurate and computationally much faster than CST Microwave Studio and similar commercial software.
QTL mapping for low-dose ethanol activation in the LXS recombinant inbred strains.

BACKGROUND Most mouse quantitative trait loci (QTLs) for behavioral traits have been mapped using populations of mice derived from C57BL/6J (B6) and DBA/2J (D2). It is also important to identify QTLs for behavior in populations derived from other progenitors. We report results from QTL mapping for low-dose (ethanol) locomotor activation (LDA) using the recently developed LXS recombinant inbred (RI) strains, derived from Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) progenitors. The LXS RI panel has additional genetic variation, and greater power due to a larger number of strains, compared with other RI panels and strain crosses. METHODS Mice were tested using a 3-day protocol in which activity levels were monitored for 15 minutes each day. On day 1, baseline activity was recorded; on day 2, mice were injected with saline before testing; and on day 3, mice were injected with 1.8 g/kg ethanol and tested. RESULTS Several suggestive QTLs were found, on chromosomes 2, 3, 4, 7, 8, 12, and 13; 3 of these QTLs were sex-specific. CONCLUSIONS Two apparently novel LDA QTLs were identified, on chromosomes 4 and 8. The other QTLs appear to replicate previously identified LDA QTLs. These replicated QTLs will be pursued in subsequent studies designed to identify candidate genes.
Institutional distance and international networking

Abstract We focus on how small- and medium-sized enterprises (SMEs) adapt to differences in institutional logics (values, beliefs, and rules) in their networking when they enter an institutionally distant market. We address gaps in the literature, relating to the role of institutional logics in SME internationalization, and how institutional distance affects the formation of network ties. We show how the social interaction involved in internationalization is embedded in the institutional logics followed by partnering actors. Specifically, we demonstrate how institutional distance may constrain the networking activities of SMEs and identify practices that may support successful internationalization.
The Determinants of Firm Performance and Bribery: Evidence from Manufacturing Firms in Nigeria

ABSTRACT This paper uses ordinary least squares with firm effects and Probit regression models to investigate the determinants of firm performance and the likelihood of firms to pay bribes. Results for the manufacturing firms in Nigeria show that skilled workforce, exports, foreign ownership and capital investment influence firm performance. Conversely, poor electricity delivery and difficulty obtaining finance impede firm performance. Total sales and time spent dealing with government regulations increase the likelihood of firms to pay bribes. Surprisingly, foreign firms are as much likely to pay bribes as domestic firms. Policy implications from the findings are important considering that the manufacturing sector assumes an important role in the Lewis theory of economic development.
Diagnosing Risk in Radical Innovation Projects

OVERVIEW: Radical innovation projects are inherently risky. A number of in-depth case studies have been carried out to identify the kinds of risk that are characteristic of this type of new product development project. Two kinds of risk were identified. The first—unambiguous risk—was high for three basic questions: 1) Will the new product perform according to specifications (balance between the product components and functional product format)? 2) Can we rely on our suppliers (quality and contract arrangements)? 3) Will consumers adopt the new product (fit with standards and demands, and fit with habits and user conditions)? The second kind of risk—ambiguous risk—included risks for which there were strong differences of opinion concerning internal organization and project management. These results provide guidelines that can help industrial R&D managers improve their companies' innovation capabilities.
Evaluation of the Estrous Cycle, Reproductive Tract, and Mammary Gland in Female Mice

Evaluation of the female reproductive system is an important part of basic reproductive biology research, toxicology testing, and mutant mouse phenotype assessment. The female reproductive system is dynamic and the onset of puberty and the normal changes observed during estrous cyclicity can create challenges for an investigator. Experimental work in the female mouse requires an understanding of the potential impact of the estrous cycle and tracking normal changes throughout the cycle allows for control of this key variable. The estrous cycle can be evaluated using vaginal cytology, which provides the researcher a daily assessment of the entire reproductive endocrine axis and allows for samples to be collected at precise times within the cycle. These protocols describe the basic approach to evaluating the onset of cyclicity, tracking the normal cycle, and collection and microscopic evaluation of the reproductive system and mammary gland in the mouse. © 2017 by John Wiley & Sons, Inc.
Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus.

OBJECTIVE Patients with systemic lupus erythematosus (SLE) are often characterized by cellular as well as humoral deficiencies in the recognition and phagocytosis of dead and dying cells. The aim of this study was to investigate whether the remnants of apoptotic cells are involved in the induction of inflammatory cytokines in blood-borne phagocytes. METHODS We used ex vivo phagocytosis assays comprising cellular and humoral components and phagocytosis assays with isolated granulocytes and monocytes to study the phagocytosis of secondarily necrotic cell-derived material (SNEC). Cytokines were measured by multiplex bead array technology. RESULTS We confirmed the impaired uptake of various particulate targets, including immunoglobulin-opsonized beads, by granulocytes and monocytes from patients with SLE compared with healthy control subjects. Surprisingly, blood-borne phagocytes from two-thirds of the patients with SLE took up SNEC, which was rarely phagocytosed by phagocytes from healthy control subjects or patients with rheumatoid arthritis. Supplementation of healthy donor blood with IgG fractions derived from patients with SLE transferred the capability to take up SNEC to the phagocytes of healthy donors. Phagocytosis-promoting immune globulins also induced secretion of huge amounts of cytokines by blood-borne phagocytes following uptake of SNEC. CONCLUSION Opsonization of SNEC by autoantibodies from patients with SLE fosters its uptake by blood-borne monocytes and granulocytes. Autoantibody-mediated phagocytosis of SNEC is accompanied by secretion of inflammatory cytokines, fueling the inflammation that contributes to the perpetuation of autoimmunity in SLE.
Multiple-Band Antenna for In-building Coverage Operation

A monopole disc antenna for multi band system operation is presented. The operating frequency of the proposed in-building antenna includes the GSM 900, GSM 1800 and 3G bands. The antenna structure consists of a two-steps cylinder combined with a circular disc to provide broadband characteristics. This antenna has a VSWR les 1.5 and an omni-directional radiation pattern at all bands. The proposed monopole disc antenna was designed according to stringent electrical and mechanical specifications. In this paper, both simulated and actual measurement results are presented. In addition, we have included a walk-test (field trial) result to verify the antennas performance in an in-building environment.
Heart rate variability in menopausal hot flashes during sleep

Objective:The aim of this study was to determine if heart rate variability changes during hot flashes recorded during sleep. Methods:This study was performed in a university medical center laboratory with 16 postmenopausal women demonstrating at least four hot flashes per night. Polysomnography, heart rate, and sternal skin conductance to indicate hot flashes were recorded in controlled, laboratory conditions. ResultsL:For the frequency bin of 0 to 0.15 Hz, spectral power was greater during waking compared with non-rapid eye movement sleep and less during stages 3 and 4 compared with stages 1 and 2. Power was greater during hot flashes compared with subsequent periods for all hot flashes. Power was greater during hot flashes compared with preceding and subsequent periods for those recorded during stage 1 sleep. For waking hot flashes, power in this band was higher before hot flashes than during or after them. Conclusions:These data are consistent with our theory of elevated sympathetic activation as a trigger for menopausal hot flashes and with previous work on heart rate variability during the stages of sleep.
Magnified endoscopic observation of small depressed gastric lesions using linked color imaging with indigo carmine dye

Abstract Background and study aims Magnifying linked color imaging with indigo carmine dye (M-Chromo-LCI) enables sterically enhanced and color image-magnified observation of the superficial gastric mucosa. This study investigated the usefulness of M-Chromo-LCI for the differential diagnosis of gastric lesions. Patients and methods 100 consecutive small depressed lesions were examined with conventional white-light imaging (C-WLI), magnifying blue-laser imaging (M-BLI), and M-Chromo-LCI. Endoscopic images were reviewed by three experts and three non-experts. Diagnostic accuracy and interobserver agreement were compared among the modalities. Results For experts, M-BLI showed a significantly higher diagnostic accuracy than C-WLI (82.7 % vs. 67.0 %; P < 0.001). The diagnostic accuracy of M-Chromo-LCI was not different from M-BLI (87.7 % vs. 82.7 %; P = 0.31). For non-experts, M-BLI showed a significantly higher diagnostic accuracy than C-WLI (69.3 % vs. 52.3 %; P < 0.001). M-Chromo-LCI additionally showed a significantly higher diagnostic accuracy than M-BLI (79.7 % vs. 69.3 %; P = 0.005). M-Chromo-LCI had the highest interobserver agreement for each group. Conclusions: M-Chromo-LCI is expected to become a useful modality for the accurate diagnosis of gastric lesions.