Miracle-dz/UniFAR-FTUs huggingface dataset:
Receptor-positive Gliomas Growth Factor for Molecular Targeting of EGF Convection-enhanced Delivery of Boronated Epidermal Updated Version

Convection enhanced delivery (CED) is potentially a powerful method to improve the targeting of macromolecules to the central nervous system by applying a pressure gradient to establish bulk flow through the brain interstitium during infusion. The purpose of the present study was to evaluate CED as a means to improve the intracerebral and intratumoral (i.t.) uptake of a heavily boronated macromolecule (dendrimer; BD) linked to epidermal growth factor (EGF) for neutron capture therapy in rats bearing a syngeneic epidermal growth factor receptor (EGFR) glioma. Boronated EGF was radiolabeled with I and administered by CED at a rate of 0.33 l/min for 15, 30, and 60 min [infusion volumes (VI) of 5, 10, and 20 l, respectively], using a syringe pump connected to an indwelling cannula implanted into the right caudate nucleus of normal rats or i.t. in rats bearing either F98EGFR or F98 wild-type (F98WT) gliomas. After infusion, rats were euthanized, and their brains were removed and serially sectioned. The uptake and biodistribution of Iboronated EGF in tumor or brain was studied by quantitative autoradiography and -scintillation counting. The volume of distribution (Vd) in brain was assessed using a computer interfaced image analysis system. After CED, the Vd increased from 34.4 to 123.5 l with corresponding Vi ranging from 5 to 20 l. The Vd of BD-EGF in the brain was 64.8 13.4 l with CED (Vi 10 ), and the Vd:Vi ratio was 6.5 compared with a Vd of 9.4 1.6 l and a Vd:Vi ratio of 0.9 after direct intracerebral injection. As determined by quantitative autoradiography and -scintillation counting at 24 h after CED, 47.4% of the injected dose per gram tissue (%ID/g) was localized in F98EGFR gliomas compared with 33.2%ID/g after direct i.t. injection and 12.3%ID/g in F98WT gliomas. On the basis of these observations, we have concluded that CED is more effective than i.t. injection as a way to deliver boronated EGF to EGFR ( ) gliomas for boron neutron capture therapy.
Mouse resources for craniofacial research

The mouse, as a genetically defined and easily manipulated model organism, has played a critical role in unraveling the mechanisms of craniofacial development and dysmorphology. While numerous gene knockout strains that display craniofacial abnormalities and essential recombinase tool strains with craniofacial‐specific expression have been generated, many are absent from public repositories. Large‐scale, international resource‐generating initiatives promise to address this concern, providing a comprehensive set of targeted mutations and a suite of new Cre driver strains. In addition, panels of genetically defined strains provide tools to dissect the multigenic, complex nature of craniofacial development, adding to the foundation of information gained from single gene studies. Continued progress will require awareness and access to these essential mouse resources. In this review, current mouse resources, large‐scale efforts, and potential future directions will be outlined and discussed. genesis 49:190–199, 2011. © 2011 Wiley‐Liss, Inc.
Ontology based requirements analysis: lightweight semantic processing approach

We propose a software requirements analysis method based on domain ontology technique, where we can establish a mapping between a software requirements specification and the domain ontology that represents semantic components. Our ontology system consists of a thesaurus and inference rules and the thesaurus part comprises domain specific concepts and relationships suitable for semantic processing. It allows requirements engineers to analyze a requirements specification with respect to the semantics of the application domain. More concretely, we demonstrate following three kinds of semantic processing through a case study, (1) detecting incompleteness and inconsistency included in a requirements specification, (2) measuring the quality of a specification with respect to its meaning and (3) predicting requirements changes based on semantic analysis on a change history.
Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras

Shc proteins are phosphorylated on tyrosine residues and associate with growth factor receptor-bound protein 2 (Grb2) upon treatment of cells with epidermal growth factor (EGF) or insulin. We have studied the role of Shc in insulin- and EGF-induced activation of p21ras in NIH 3T3 cells overexpressing human insulin receptors (A14 cells). A14 cells are equally responsive to insulin and EGF with respect to activation of p21ras. Analysis of Shc immunoprecipitates revealed that (i) both insulin and EGF treatment resulted in Shc tyrosine phosphorylation and (ii) Shc antibodies coimmunoprecipitated both Grb2 and mSOS after insulin and EGF treatment. The induction of tyrosine phosphorylation of Shc and the presence of Grb2 and mSOS in Shc immunoprecipitates followed similar time courses, with somewhat higher levels after EGF treatment. In mSOS immunoprecipitates, Shc could be detected as well. Furthermore, Shc immune complexes contained guanine nucleotide exchange activity toward p21ras in vitro. From these results, we conclude that after insulin and EGF treatment, Shc associates with both Grb2 and mSOS and therefore may mediate, at least in part, insulin- and EGF-induced activation of p21ras. In addition, we investigated whether the Grb2-mSOS complex associates with the insulin receptor or with insulin receptor substrate 1 (IRS1). Although we observed association of Grb2 with IRS1, we did not detect complex formation between mSOS and IRS1 in experiments in which the association of mSOS with Shc was readily detectable. Furthermore, whereas EGF treatment resulted in the association of mSOS with the EGF receptor, insulin treatment did not result in the association of mSOS with the insulin receptor. These results indicate that the association of Grb2-nSOS with Shc may be an important event in insulin-induced, mSOS-mediated activation of p21ras.
Framing Terror

The study identifies seven rhetorical strategies newspapers use to frame the acts of violence as terrorism or crime by comparatively analyzing the news coverage of the Ft. Hood and the Washington, D.C., Navy Yard shootings in three major newspapers. It examines the framing of the incidents, the strategies used to constitute the frames, the functions these strategies serve, and the media’s contribution to the discourse of terror.
Development of a Problematic Mobile Phone Use Scale for university students: validity and reliability study -

Objective: This study aims to develop a Problematic Mobile Phone Use Scale (PMPUS) to determine the problematic mobile phone use by university students. Method: Study participants for exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were 725 university students, for test-retest 126 university students. The psychometric characteristics of the scale were investigated using test-retest, internal consistency (Cronbach’s alpha), item analysis, EFA, CFA, and criterion-related validity methods. Results: According to results obtained from exploratory factor analysis, it was determined that PMPUS had four subdimensions. Confirmatory factor analysis confirmed this four-subdimension structure. Reliability data for the PMPUS found Cronbach’s Alpha coefficients of 0.92 for EFA and 0.93 for CFA, respectively. Test-retest coefficient for PMPUS was 0.85. Furthermore, a positive, high correlation (r=0.75) was found between PMPUS and Mobile Phone Problem Use Scale (MPPUS). Subscales of PMPUS also showed the required values for validity and reliability. Conclusion: According to the results, PMPUS is a reliable and valid scale with 26 items in four subdimensions.
Aqua(9,10-dioxoanthracene-1,5-disulfonato-κO 1)bis(1,10-phenanthroline-κ2 N,N′)nickel(II)

In the mononuclear title complex, [Ni(C14H6O8S2)(C12H8N2)2(H2O)], the NiII atom is in a distorted octahedral coordination formed by four N atoms from two chelating 1,10-phenanthroline ligands and by two O atoms, one from a 9,10-dioxoanthracene-1,5-disulfonate ligand and the other from a water molecule. An intramolecular O—H⋯O hydrogen bond occurs. In the crystal, intermolecular O—H⋯O hydrogen bonds link the mononuclear complexes into chains extending parallel to [010]. Furthermore, π–π stacking interactions [centroid–centroid distance = 3.5696 (6) Å] stabilize the crystal structuure.
Actualizing real‐time indoor positioning systems using plane models

Compared with other indoor positioning methods, pattern matching offers greater accuracy. However, its construction requires additional time and manpower cost, and larger positioning environments result in correspondingly greater construction costs and computing complexity. To reduce the cost and computing complexity of pattern construction, plane models featuring radio signals were adopted in conjunction with quick response codes to facilitate the simple and rapid construction of indoor environments in this study. The advantages of using plane equations instead of pattern matching radio maps for positioning computations include the following: (1) reducing the complexity of positioning computations; (2) eliminating the influences of positioning area size; and (3) providing reliable and accurate positioning with an average error of approximately 2.8 m. Copyright © 2015 John Wiley & Sons, Ltd.
Boosting Recommender Systems with Deep Learning

Farfetch is a global fashion marketplace with a catalog that, at any time, has over 200 000 products spanning over 2000 brands from luxury boutiques all around the world. Finding the right product to the right customer is a challenge that, we, as Data Scientists working on the Recommendations team, are trying to solve using state-of-the art algorithms and disruptive technologies. Deep learning (DL) is an area of Machine Learning that has recently been brought to the spotlight for its breakthrough results across several domains. In this talk, we will provide an overview of some ongoing projects in which Deep Learning methods play a major role. A common problem in online marketplaces with large catalogs such as ours is the lack of detailed metadata about the products. Particularly, features such as style, colors, pattern, occasion, sizing, etc., are known to drive customers intent but are hard to catalog manually, in a consistent way. We explain how we use our extensive dataset of normalized product images together with state of the art convolutional neural networks to extract visual features. These can then be used to provide better recommendations and improve other applications across the platform. Another application of DL is to capture relationships between products which are stylistically complementary. We leverage data from thousands of hand-curated outfits to model these intangible fashion concepts only a human specialist can provide, and generalize a method of recommending complementary products using deep siamese neural networks. This an alternative recommendation strategy that can be used to drive cross-sell opportunities. These are merely a sample of problems we are tackling using DL at Farfetch. We believe that there are plenty of opportunities for application of these techniques to recommender systems and we look forward to discussing the potentials of this stream of research with the RecSys community.
Delay-Bounded Transmission Power Control for Low-Duty-Cycle Sensor Networks

Low-duty-cycle operation has been adopted to alleviate the consumption rate of energy, which is significant for the power scarcity sensor networks. The sleep latency brought by low-duty-cycle mode, however, leads to a dramatic increase of delay, which may not be tolerable for delay-sensitive applications. In this work, we introduce the transmission power control mechanism into low-duty-cycle sensor networks. Particularly, we propose Delay-bounded Transmission Power Control (DTPC), a cross-layer approach, to minimize the energy consumption of sensor nodes while meeting the user-specified delay constraint. In DTPC, each node builds its own transmission table using dynamical programming and then adaptively selects the approximate forwarding entry according to the delay bound. In addition, our design is embedded to support both single-parent and multi-parent data forwarding scheme. The extensive simulations and test-bed experiment results show that DTPC can guarantee the delay bound with much lower energy cost compared with other well-known schemes.
Midfacial T Cell Lymphoma: Characterization by Monoclonal Antibodies

Three cases of so-called lethal midline granuloma were studied immunologically, using monoclonal antibodies against T cell subsets, and electron microscopically. Immunofluorescence and immunoperoxidase studies of their surgical and autopsy specimens proved that the tumor cells showed positive stainings with anti-Leu 1 and anti-Leu 3a antibodies, and negative staining with anti-Leu 2a, anti-HLA-DR, and anti-immunoglobulin antibodies. These data might indicate that the tumor cells of the three cases had a similar surface antigen phenotype to that of peripheral helper-inducer T cells. The histopathological and ultrastructural examinations of the tumors showed general characteristics reported for T cell lymphomata derived from peripheral T cells.
A new and simple cryosectioning protocol for pollen analysis under light microscopy

Conventional plant microtechniques typically involve fixation, dehydration, and embedding in acrylic or epoxy resins followed by room temperature microtomy. Some cryomethods have been used for pollen grain analysis under light microscopy. However, these protocols do not allow for obtaining sections with similar or better quality compared to resin embedding methods. In this paper, a simple cryoprotocol for use in pollen studies under light microscopy is presented. Aldehyde-fixed anthers were cryoprotected in an aqueous sucrose solution and frozen in liquid nitrogen. A simple and inexpensive water-based gelatin–sucrose solution was used to support samples for frozen sectioning. With this new method, 1 μm thick sections were cut in a cryostat at -30 °C. The pollen grain sections showed cell structures with excellent preservation. Furthermore, different sublayers of the intine can be visualised with unprecedented clarity. The pollen cryostat sections have a higher level of quality than those of the resin embedding protocols at the same thickness. The main advantage to the method is the absence of artefacts, such as shrinkage and lipid extraction, caused by solvent dehydration and resin inclusion. Since the sections remain hydrated and free of embedding resins, the stain action is faster and more effective.
Comparative evaluation of the marginal sealing ability of Fuji VII and Concise as pit and fissure sealants.

AIM The anatomical pits and fissures of the teeth have long been recognized as susceptible areas for the initiation of dental caries. The extreme vulnerability to decay of these pits and fissures on the occlusal surfaces has prompted dental scientists to seek methods of caries prevention. Motivated by the role of pit and fissure sealants in caries prevention, the aim of this study was to compare the efficacy of Fuji VII glass ionomer sealant and Concise resin-based sealant. METHODS AND MATERIALS An in vitro study was undertaken using forty premolars extracted for orthodontic reasons. The teeth were divided into two groups and sealants were applied. One was an experimental group using Fuji VII as a pit and fissure sealant and the other a control group using Concise. The teeth were kept in gentian violet dye for 24 hours, the sectioned samples were observed for the extent of dye penetration, and scores were based on established scoring criteria. RESULTS The comparison of the performance of the two groups showed a statistically significant difference. CONCLUSION The Concise resin-based sealant performed better in terms of sealing ability than did the Fuji VII glass ionomer sealant.
Implementation and evaluation of multihop ARQ for reliable communications in underwater acoustic networks

Underwater acoustic networking is an emerging technology platform for oceanographic data collection, pollution monitoring, offshore exploration and tactical surveillance applications. Design of reliable and efficient communications protocols is challenging due to the unique characteristics of underwater acoustic channels. In this paper, we present a modular and lightweight implementation of an opportunistic multihop automatic repeat request (ARQ) scheme in a real system. We evaluate the performance of the opportunistic ARQ using inexpensive underwater acoustic modems in a shallow underwater environment.
The Role of Self-efficacy in Injury Avoidance and Fear of Injury among Elite Athletes

For athletes at the competitive level, injury due to the sport is highly probable. Athletes must continually deal with existing injuries and fears of new injuries throughout the season, which can cause considerable stress. Selfefficacy has been shown to influence how people feel, think and motivate themselves through personal judgements and perceptions made about their abilities. Self-efficacy theory shows us that the act of agency within our own lives can help us to deal with controlling how to act and behave in our lives. In turn, this agency manifests in a feeling of confidence to control the external world and has been shown to increase the probability of achieving intended goals. This survey study explored the relation between self-efficacy in the domain of injury avoidance with elite football players in the Canadian Football League. Data collection spanned over 5 years and across 317 players on measures of the effects that past injury had on current self-efficacy beliefs, as well as how self-efficacy could predict future behaviors towards injury avoidance. Our analysis of the variance showed a significant relation of injury frequency, severity and type to current self-efficacy to avoid injury. Our results showed a reciprocal and cumulative nature of self-efficacy with injury. Specifically, self-efficacy can affect future injury avoidance and injury can have the effect to lower an athlete’s confidence in future injury avoidance. The results have important implications for theory, research, and practice regarding sports psychology, counselling, and injury avoidance and recovery literature.
Normothermic Acellular Machine Perfusion and Bile Duct Injury in Pig Livers Retrieved After Cardiac Death

We have read with interest the article by Boehnert et al (1), describing normothermic acellular machine perfusion of pig livers donated after cardiac death (DCD). The authors should be commended for performing this important study which adds to the evidence that normothermic machine perfusion (NMP) is a promising method to reduce biliary injury after transplantation of DCD livers. Using an erythrocyte-based perfusion fluid, our group previously reported the feasibility of NMP of human DCD livers, emphasizing that this preservationmethod is about to enter the clinical arena (2). Nevertheless, there are still some unanswered questions that are not fully addressed by Boehnert et al (1).
Results from Simulations to Show the Relative Impact of Uninformative Pairs on QTL Analysis for Different Values of Polygenic and QTL Heritability and Different Percentages of Uninformative Markers

a The data in the first two rows correspond to the simulated scenario (2) of Cordell (2004) and are based on 10,000 replicates. For all other data, a normally distributed additive QTL was simulated, and results are averages from 1,000 replicates. b dT is the average difference between the test statistic achieved when uninformative pairs are removed from the analysis and the one achieved when they are kept in the analysis. j(d) is the SD of the difference between the test statistic achieved when uninformative pairs are removed from the analysis and the one achieved when they are kept in the analysis. E(T) is the average test statistic achieved when uninformative markers are removed from the analysis. j(T) is the SD of the test statistic when uninformative markers are removed from the analysis. All ratios are expressed as percentages.
Channel mismatch background calibration for pipelined time interleaved ADCs

This paper presents a background calibration technique for channel mismatch errors in pipelined time interleaved ADCs. These mismatches include gain and offset mismatches for pipelined sub-ADC's stages and the time skew error for each sub-ADC. The presented calibration technique is based on least mean-square adaptive filtering and requires an extra slow but accurate sub-ADC. The technique was implemented on an FPGA to evaluate its resource utilization. Simulation results demonstrate a 40 dB improvement in the measured SNR.
Morphologic changes of middle ear mucosa in chronic otitis media with or without cholesteatoma

OBJECTIVE: To investigate histopathologic differences between chronic otitis media (COM) with cholesteatoma and COM without cholesteatoma. MATER‹ALS AND METHODS: This retrospective study is an analysis of 74 middle ear biopsies from the promontory near the round window taken at first operation for COM performed. Thirty ears had COM with cholesteatoma. The other 44 ears had COM without cholesteatoma. Materials were stained by Hematoxylin-eosin and Toluidine blue. Density of gland and secretory cell, epithelial thickness, number of ciliated cell, infiltration and migration of chronic inflammatory cells (lymphocyte and plasma cell) and grade of vascular dilatation and proliferation between the patients with or without cholesteatoma were compared. The analysis of quantitative parameters was performed using Pearson χ test. RESULTS: Infiltration and migration of lymphocyte and plasma cells, and grade of vascular dilatation and proliferation were significantly greater in ears without cholesteatoma than those with cholesteatoma. CONCLUS‹ONS: These findings indicate that distinct physiopathologic mechanisms may play role in development of COM in terms of presence of cholesteatoma. Cholesteatoma may lead to destruction of vascular structures and chronic inflammatory cells by means of its pressure effect, numerous enzyme and cytokines. Ac›badem Hospital, Bursa, (S. Yetifler), TURKEY, Gulhane Medical School, Dept of ORL & HNS, Etlik-Ankara, (Y. H›d›r), Gulhane Medical School, Dept of Pathology, Etlik-Ankara, (M.S. Deveci), TURKEY