Miracle-dz/UniFAR-FTUs huggingface dataset:
Reduced Yin-Yang-Pair optimization and its performance on the CEC 2016 expensive case

We present a variant of the Yin-Yang-Pair Optimization metaheuristic which accommodates computationally expensive numerical optimization problems more effectively. The variations are directed at simplifying the algorithm as well as enabling it to utilize functional evaluations more efficiently. The performance of Reduced Yin-Yang-Pair Optimization is tested on the functions used for the CEC 2016 Special Session on Bound Constrained Single-Objective Computationally Expensive Numerical Optimization. Additionally, the performance of the algorithm is evaluated based on the criteria specified for the same. The RYYPO is shown to have a significantly low time complexity while simultaneously providing highly competitive performance.
Applications of data mining in health and pharmaceutical industry

The Data mining is gradually becoming an integral and essential part of health and pharmaceutical industry. Data mining techniques are being regularly used to assess efficacy of treatment, management of ailments, and also in various stages of drug discovery and process re- search. Off late, data mining has become a boon in health insurance sector to minimize frauds and abuse. A good number of health care compa- nies, medical hospitals and pharmaceutical manufacturing units are employing the data mining tools due their excellent efficiency. The identifica- tion and quantification of pharmaceutical information can be extremely useful for patients, physicians, pharmacists, health organizations, insur- ance companies, regulatory agencies, investors, lawyers, pharmaceutical manufacturers, drug testing companies. This review deals with the ma- jor applications of data mining techniques in health care and pharmaceutical industries with relevant examples.
Real-time on-road vehicle and motorcycle detection using a single camera

A real-time monocular vision based rear vehicle and motorcycle detection and tracking approach is presented for Lane Change Assistant (LCA). To achieve robustness and accuracy this work detects and tracks multiple vehicles and motorcycles on road by combining multiple cues. To achieve real-time multi-resolution technology is used to reduce computing complexity, and all algorithms have been implemented on an IMAP (Integrated Memory Array Processor) parallel vision board. The test results under various traffic scenes illustrated accuracy, robustness and real-time of this work.
Nomos and Narrative in Jewish Law: The Care of the Dying Patient and the Prayer of the Handmaid

The most frequent and difficult moral quandary faced by medical ethicists is how much effort must be expended to treat a dying patient. This dilemma is a daily occurrence in modern hospitals and causes much anguish to patients and their families. With the advent of new technologies such as mechanical ventilation and dialysis, patients that would have died quickly in the past can now linger for months dependent on these machines for their survival. These developments forced the issue of whether all patients should receive these life extending treatments or be allowed to die without aggressive treatment. The Western liberal answer to this question based on the principles of autonomy and human freedom, has been to let the patient decide how they want to die. The Catholic Church has differentiated between ordinary care which they require and extraordinary care which they leave to the patient’s discretion. Naturally, Jewish decisors where also called upon to address the issue. The primary halachic source for the discussion is the gloss of the Rama in the authoritative Code of Jewish Law:
Ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by inhibition of drug resistance

It has been reported that ursolic acid has anti‐tumor activity and it enhances the therapeutic effect of oxaliplatin in colorectal cancer (CRC). However, the underlying mechanisms remain unknown. In the present study, the mechanisms of the enhancement of therapeutic effects through use of ursolic acid were investigated. We treated CRC cell lines HCT8 and SW480 with ursolic acid and oxaliplatin and monitored the effects on cell proliferation, apoptosis, reactive oxygen species (ROS) production and drug resistance gene production. We discovered that treatment with a combination of ursolic acid and oxaliplatin resulted in significant inhibition of cell proliferation, significantly increased apoptosis and ROS production, and significant inhibition of drug resistance gene expression. Our study provided evidence that ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by ROS‐mediated inhibition of drug resistance.
Concurrent and Recoverable Restructuring Method for Database Indices

In this paper, we present a top-down restructuring method for Bplusmntrees in which a structure modification such as page split or merge is executed as an atomic action. Each structure modification is logged using a single redo-only log record. The execution of each structure modification involves X-latching three pages at most on two adjacent levels of the Bplusmntree for short duration. A Bplusmntree structure modification, once executed to completion can never be undone no matter if the transaction that triggered such a structure modification commits or aborts later on. Recoverability of the Bplusmntree structure is guaranteed because the redo pass of our ARIES-based recovery protocol produces a structurally consistent tree. The method improves concurrency, simplifies recovery, reduces the amount of logging, and can be used in systems that use redo-only or redo-undo recovery protocols
A Eukaryotic Type Serine/Threonine Kinase and Phosphatase inStreptococcus agalactiae Reversibly Phosphorylate an Inorganic Pyrophosphatase and Affect Growth, Cell Segregation, and Virulence*

Protein phosphorylation is essential for the regulation of cell growth, division, and differentiation in both prokaryotes and eukaryotes. Signal transduction in prokaryotes was previously thought to occur primarily by histidine kinases, involved in two-component signaling pathways. Lately, bacterial homologues of eukaryotic-type serine/threonine kinases and phosphatases have been found to be necessary for cellular functions such as growth, differentiation, pathogenicity, and secondary metabolism. The Gram-positive bacteria Streptococcus agalactiae (group B streptococci, GBS) is an important human pathogen. We have identified and characterized a eukaryotic-type serine/threonine protein kinase (Stk1) and its cognate phosphatase (Stp1) in GBS. Biochemical assays revealed that Stk1 has kinase activity and localizes to the membrane and that Stp1 is a soluble protein with manganese-dependent phosphatase activity on Stk1. Mutations in these genes exhibited pleiotropic effects on growth, virulence, and cell segregation of GBS. Complementation of these mutations restored the wild type phenotype linking these genes to the regulation of various cellular processes in GBS. In vitro phosphorylation of cell extracts from wild type and mutant strains revealed that Stk1 is essential for phosphorylation of six GBS proteins. We have identified the predominant endogenous substrate of both Stk1 and Stp1 as a manganese-dependent inorganic pyrophosphatase (PpaC) by liquid chromatography/tandem mass spectrometry. These results suggest that these eukaryotic-type enzymes regulate pyrophosphatase activity and other cellular functions of S. agalactiae.
Galactose Metabolism by Streptococcus mutans

ABSTRACT The galK gene, encoding galactokinase of the Leloir pathway, was insertionally inactivated in Streptococcus mutans UA159. The galK knockout strain displayed only marginal growth on galactose, but growth on glucose or lactose was not affected. In strain UA159, the sugar phosphotransferase system (PTS) for lactose and the PTS for galactose were induced by growth in lactose and galactose, although galactose PTS activity was very low, suggesting that S. mutans does not have a galactose-specific PTS and that the lactose PTS may transport galactose, albeit poorly. To determine if the galactose growth defect of the galK mutant could be overcome by enhancing lactose PTS activity, the gene encoding a putative repressor of the operon for lactose PTS and phospho-β-galactosidase, lacR, was insertionally inactivated. A galK and lacR mutant still could not grow on galactose, although the strain had constitutively elevated lactose PTS activity. The glucose PTS activity of lacR mutants grown in glucose was lower than in the wild-type strain, revealing an influence of LacR or the lactose PTS on the regulation of the glucose PTS. Mutation of the lacA gene of the tagatose pathway caused impaired growth in lactose and galactose, suggesting that galactose can only be efficiently utilized when both the Leloir and tagatose pathways are functional. A mutation of the permease in the multiple sugar metabolism operon did not affect growth on galactose. Thus, the galactose permease of S. mutans is not present in the gal, lac, or msm operons.
Wong Kar-wai’s Films and the Culture of the Kawaii

Since 1988, the year of the release of As Tears Go By, many academic texts have been written about Wong Kar-wai and his films. Among the themes dealt with are 1) Wong's emergence from the Hong Kong cinema scene and the exceptional status he enjoys within that scene; and 2) the similarities between Wong and an extremely wide range of Western directors. The twofold concentration on Wong's Hong Kong origins on the one hand, and his compatibility with Western cinema on the other, can be explained through Wong's almost unique ability to make films that appear to be equally Chinese and Western, or equally local and global.1 However, in my opinion, any limitation of analysis to a dialectics of Eastern and Western elements runs the risk of bypassing by the real sources of Wong's oeuvre. I am not aware of a single study that attempts to integrate Wong in the wide, though limited, cultural sphere of modern or post-modern East Asia. Stephen Teo points to Wong's Asian literary influences, such as the novels of Osamu Daizai and Haruki Murakami. He even sees "a film like 2046 [as] living proof of Wong's global and pan Asian strategy (it features stars from all the Asian territories mentioned, while the device of having these stars speak in their own mother tongues is also part of the strategy)" (152-53). I want to extend Teo's anticipations and explain Wong's work by not reducing it to a selective amalgamation of "East" and "West," but by understanding it as a phenomenon flowing out of a sphere that must be considered as having a culture of its own: the sphere of modern East Asian culture. By using this approach, I seek to avoid relativism like that expressed by Jenny Kwok who claims that "the Third World is so infiltrated with First World images and narratives that it is not possible to identify Third World 'national' symbolic products anymore" (22), a relativism that affirms that national characteristics do not exist at all. On the other hand, I want to avoid the essentialism that sees films and all cultural productions as expressions of national culture. Wong's world is neither the traditional Chinese one nor the "globalized" or international one, but that of lower middle-class inhabitants of
Relational exploration: combining description logics and formal concept analysis for knowledge specification

4 Danksagungen Contents Introduction 7 1 FCA and Attribute Exploration 11 1. Introduction In the Palace of the Vatican, on a wall of a room called stanza della segnatura, the visitor encounters the fresco The School of Athens created by the famous renaissance painter Raphael around 1509. It shows renowned representatives of the ancient artes liberales led by philosophy. Right in the center of this masterpiece, one finds the certainly most brilliant greek philosophers (besides Socrates): Plato and Aristotle. While Plato points up indicating his belief in the primacy of ideas situated in a higher world of forms, Aristotle holds his hand palm downwards suggesting a more grounded epistemic view, where real world facts (or in modern terms: the data) govern the way how concepts and classifications are formed. These two perspectives can be traced through the entire occidental philosophy occurring here and there in varying guises (cf. also the problem of universals or the bipolar setting rationalism vs. empirism brought up in the 19th century). These antagonistic approaches personified by the two philosophers seem also characteristic for the underlying ways of thinking in two fields of knowledge processing and representation, we want to deal with in our work: Formal Concept Analysis (FCA) and Description Logic (DL). The – more Aristotelian – mathematical theory of Formal Concept Analysis came into being some twenty years ago as the attempt to model (hierarchies of) concepts in terms of lattice theory. It is based on the dualistic understanding of concepts as consisting of concept extent (i.e., all entities belonging to that concept) and concept intent (i.e., all attributes characterizing it). FCA has proven solid in theory but also quite intuitive in representing conceptual knowledge, also for mathematically less skilled people. Thus, it has been successfully applied in various areas beyond mathematics. Besides this representational capabilities, algorithms assisting knowledge acquisition have been developed, implemented and used in practice. In recent years, FCA has been developed further and extended by the project 8 Introduction of contextual logic, widening the scope of interest from concepts to judgments. In the course of these developments, the relational aspect has been increasingly emphasized. Description Logics being a collective term for a family of knowledge representation formalisms are the result of a development starting in the 1970s with frame based systems and semantic networks. The common underlying idea is to characterize classes of entities (resp. objects) of a domain and …
Linkage disequilibrium between intra‐locus variants in the aminopeptidase n gene and test of their association with coeliac disease

Coeliac disease (CD) is a multigenic and multifactorial enteropathy triggered by gluten‐composing proteins. A possible involvement of the intestinal Aminopeptidase N (APN) was investigated by an association analysis. SSCP analysis detected four variants at position 281, 378, 956 and 2957 (referred to no. g178535, GenBank) that were studied in 193 Italian CD families. The haplotypic combinations were determined from family segregation and pairwise linkage disequilibria (D′= D/Dmax) between the polymorphic sites were calculated. Significant D′ values ranged between 0.78 and 0.31. Association with CD was tested by TDT (Transmission Disequilibrium Test) utilizing as markers the nucleotide substitutions and their haplotypic combinations. No statistically significant transmission distortion to the probands or to their clinically silent sibs was observed. Our data exclude an involvement in CD of the tested markers and of further undetected variation in strong linkage disequilibrium (D′≅ 1) with them. The power of the test was not adequate to detect an association with an unknown polymorphism which is not in complete linkage disequilibrium with those analysed.
Acute toxicity and biochemical effects of azinphos methyl in the amphipod Hyalella curvispina

We evaluated the acute toxicity and biochemical effects of the organophosphorus pesticide azinphos methyl (AM) in the amphipod Hyalella curvispina that inhabits ponds and irrigation channels of an intensive fruit‐producing region in Rio Negro and Neuquén valley, North Patagonia, Argentina. The analysis by nonlinear regression of data from the 96 h‐acute toxicity tests indicated the coexistence of two subpopulations of H. curvispina with different susceptibilities to AM. The 96 h‐LC50 for the resistant subpopulation (166 ± 56 μg/L) was 216‐fold higher than the 96h‐LC50 value for the susceptible one (0.77 ± 1.33 μg/L). The two subpopulations could not be distinguished based on the biochemical measurements in control amphipods. Cholinesterase activity was significantly inhibited in AM‐exposed amphipods in a concentration‐dependent manner. The IC50 value obtained after 96 h of exposure (2.18 ± 1.95 μg/L) was significantly lower than the 48 h‐IC50 value (29.6 ± 17.4 μg/L). Carboxylesterase activity was significantly inhibited after 48 h of exposure to 12.5 and 62.5 μg/L AM (inhibition, 51%). This enzyme was thus able to protect cholinesterase from inhibition at 12.5 μg/L AM. Reduced glutathione and catalase showed a significant increase after 24 h of exposure as an adaptive response to AM, whereas glutathione S‐transferase activity was not significantly modified. The analysis of species sensitivity distribution showed that both subpopulations of H. curvispina were more tolerant to AM than most amphipod species, and that the susceptible subpopulation was more sensitive to AM than the other local aquatic species analyzed. The maximum concentration of AM in drainage water within the fruit‐producing area reported by other studies would affect most of the amphipod species (99%) and also a 44% of local aquatic ones. The results obtained in this study point out the usefulness of including amphipods like H. curvispina in ecotoxicity studies and monitoring programs to perform pesticide risk assessments. 2012 Wiley Periodicals, Inc. Environ Toxicol 29: 1043–1053, 2014.
One particle in a box: The simplest model for a Fermi gas in the unitary limit

We consider a single quantum particle in a spherical box interacting with a fixed scatterer at the center, to construct a model of a degenerate atomic Fermi gas close to a Feshbach resonance. One of the key predictions of the model is the existence of two branches for the macroscopic state of the gas, as a function of the magnetic field controlling the value of the scattering length. This model is able to draw a qualitative picture of all the different features recently observed in a degenerate atomic Fermi gas close to the resonance, even in the unitary limit.
Clozapine influences cytoskeleton structure and calcium homeostasis in rat cerebral cortex and has a different proteomic profile than risperidone

For over the last 50 years, the molecular mechanism of anti‐psychotic drugs' action has been far from clear. While risperidone is very often used in clinical practice, the most efficient known anti‐psychotic drug is clozapine (CLO). However, the biochemical background of CLO's action still remains elusive. In this study, we performed comparative proteomic analysis of rat cerebral cortex following chronic administration of these two drugs. We observed significant changes in the expression of cytoskeletal, synaptic, and regulatory proteins caused by both antipsychotics. Among other proteins, alterations in collapsin response mediator proteins, CRMP2 and CRMP4, were the most spectacular consequences of treatment with both drugs. Moreover, risperidone increased the level of proteins involved in cell proliferation such as fatty acid‐binding protein‐7 and translin‐associated factor X. CLO significantly up‐regulated the expression of visinin‐like protein 1, neurocalcin δ and mitochondrial, stomatin‐like protein 2, the calcium‐binding proteins regulating calcium homeostasis, and the functioning of ion channels and receptors.
Multiple co‐regulatory elements and IHF are necessary for the control of fimB expression in response to sialic acid and N‐acetylglucosamine in Escherichia coli K‐12

Expression of the FimB recombinase, and hence the OFF‐to‐ON switching of type 1 fimbriation in Escherichia coli, is inhibited by sialic acid (Neu5Ac) and by GlcNAc. NanR (Neu5Ac‐responsive) and NagC (GlcNAc‐6P‐responsive) activate fimB expression by binding to operators (ONR and ONC1 respectively) located more than 600 bp upstream of the fimB promoter within the large (1.4 kb) nanC‐fimB intergenic region. Here it is demonstrated that NagC binding to a second site (ONC2), located 212 bp closer to fimB, also controls fimB expression, and that integration host factor (IHF), which binds midway between ONC1 and ONC2, facilitates NagC binding to its two operator sites. In contrast, IHF does not enhance the ability of NanR to activate fimB expression in the wild‐type background. Neither sequences up to 820 bp upstream of ONR, nor those 270 bp downstream of ONC2, are required for activation by NanR and NagC. However, placing the NanR, IHF and NagC binding sites closer to the fimB promoter enhances the ability of the regulators to activate fimB expression. These results support a refined model for how two potentially key indicators of host inflammation, Neu5Ac and GlcNAc, regulate type 1 fimbriation.
Impact of Feature Selection and Feature Types on Financial Stock Price Prediction

In this paper, we examine whether stock price effects can be automatically predicted analyzing unstructured textual information in financial news. Accordingly, we enhance existing text mining methods to evaluate the information content of financial news as an instrument for investment decisions. The main contribution of this paper is the usage of more expressive features to represent text through the employment of market feedback as part of our word selection process. In a comprehensive benchmarking, we show that a robust Feature Selection allows lifting classification accuracies significantly above previous approaches when combined with complex feature types. That is because our approach allows selecting only semantically relevant features and thus, reduces the problem of over-fitting when applying a machine learning approach. The methodology can be transferred to any other application area providing textual information and corresponding effect data.
Serotonin Agents in the Treatment of Acquired Brain Injury

Background:The development of novel serotonin agents has led to an increased use of these medications throughout medical practice. An understanding of the basic pharmacological function of these agents is key to understanding their usefulness. Among persons with brain injury, serotonin agents have been used for the treatment of depression, panic disorder, obsessive-compulsive disorders, agitation, sleep disorders, and motor dysfunction. Conclusion:This article will review the mechanisms, efficacy, and side effects of serotonin agents with a focus on persons with brain injury.
Introduction of a yeast artificial chromosome vector into Saccharomyces cerevisiae cells by electroporation.

A yeast artificial chromosome vector (1) has been introduced into intact yeast cells by electroporation, both as a closed circular plasmid and as linear molecule with terminal telomeres. The procedure employed lower field strengths, higher capacitance and lower resistance than used previously (2), to minimize heat dissipation (3). The vector, pYAC4 (1) with a short oligonucleotide inserted at the EcoRI cloning site to disrupt the SUP4 reading frame, was used to transform Saccharomyes cerevisae AB 1380 to a Ura+ Trp+ red phenotype. The frequency of transformation was dependent on the electroporation parameters (Fig. 1) and was a function of DNA concentration (Fig. 2), cell number and PEG concentration (data not shown). Linearization of the plasmid increased the number of transformants about four fold compared to circular plasmid (Fig. 2) and ref. 2. Approximately 99% of the colonies had the expected Ura+ Trp+ red phenotype (1). This protocol forms the basis for examination of electroporation as a means for direct delivery of large YAC clones into yeast without the need for a spheroplast stage.