Miracle-dz/UniFAR-FTUs huggingface dataset:
Suicides in Males After the First Episode of Schizophrenia

The aim of this study was a retrospective analysis of available data on patients who committed suicide after the first episode of schizophrenia with focus on risk factors for suicide. Seven of 162 patients consecutively hospitalized at the Department of Psychiatry in Brno with first-episode schizophrenia and followed up for 10 years committed suicide by hanging (n = 4), shooting (n = 1), jumping from height (n = 1), and drowning (n = 1). All patients had more known risk factors and had visited a psychiatrist shortly before their suicide. However, according to the documentation, the patients were not asked about their intention to commit suicide and the potentially modifiable risk factors. Under the conditions of routine clinical practice, the prevention of suicide after the first psychotic episode should include early aggressive treatment and careful monitoring for suicidal behaviors in patients with known risk factors.
Financial technological Innovation and Access is the Key to Unlocking African Agricultural Potential: A Case Study of Dairy in Kenya

In Kenya agriculture contributes 24% to the GDP yet lending to the sector is only about 4%. A major constraint to increasing efficiency in smallholder enterprises in rural areas is therefore, limited access to financial services. Lack of working capital for traders in rural areas inhibits the purchase, trade and processing of agricultural produce. This limits the amount of produce a farmer can market and acts as a disincentive to reaching his/her productive potential. Furthermore, most Microfinance Institutions (MFIs) lack a value chain approach to financing and are unable to remove the financial constraints along a specific value chain. Appropriate financing services along the value chain can help to enhance the productivity and profitability of various small-scale rural stakeholders. Therefore, the study assessed the prospects for financial innovations and access in improving dairy farmers’ livelihoods through a case study approach. The findings provide a strong evidence that appropriate financial innovation is the missing link in agricultural productivity paradigm and the food security equation in African countries including Kenya.
Candida albicans SSDl can suppress multiple m u ta t i ons i n Saccharomyces cere visiae

The SSD1 gene of Saccharomyces encodes a 160 kDa cytoplasmic protein that can suppress mutations in a number of other genes. A functional homologue of SSD1 from the human pathogen Candida albicans was isolated on the basis of its ability to restore viability at the restrictive temperature in a Saccharomyces cerevisiae swi4 ssdl-d strain. The C. albicans gene, designated CaSSD1, encodes a 1262 aa protein which has 47% identity overall to S. cerevisiae SSDI as well as significant identity to Schizosaccharomyces pombe dis3 and sts5 products. It is shown that CaSSD1 expression is constitutive through the mitotic cell cycle, which is consistent with a role for the protein in cell growth. CaSSD1 rescues the swiP defect in an ssd1-d background when expressed from its own promoter on a single-copy plasmid and under the same conditions can rescue mutations in genes encoding protein phosphatase type 2A catalytic subunits. These data suggest that CaSSD1, like its S. cerevisiae homologue, can limit the effect of mutations on a variety of cellular processes.
Time-Domain, Frequency Domain and non-linear measurements in neonates' Heart Rate Variability with clinical sepsis

Sepsis, a critical bacterial infection of the bloodstream, is a serious cause of illness in neonatal period in both premature and at term newborns. It is important to look for parameters that can help earlier detection of sepsis in the newborn. Previous studies have shown that Heart Rate Variability is reduced when associated with sepsis and diminish the adaptive capacity of the individual, degrading the information transported by their signals. To test for the statistical significance in discriminating between healthy and sepsis diagnosed neonates we analyzed the Inter-Beat-Interval derived from 90 minutes electrocardiographic recordings obtained from 45 newborn, 17 with clinical diagnosis of sepsis and 28 healthy newborn as control. Statistically significant time-domain measures (p<;0.05) of the time series produced paradoxical results comparing sepsis with healthy subjects. Frequency-domain and Time-Frequency analysis show reduced low-frequency power and low/high frequency ratio (p<;0.05) in subjects with sepsis; conversely high-frequency power was significantly higher (p<;0.05) in the sepsis group. Non-linear Sample-Entropy measure showed significant difference between groups (p<;0.01) and lower values in subjects clinically diagnosed with sepsis suggesting lower Inter-Beat-Interval signal complexity.
Chemical-Based Translational Induction of Luciferase Expression: An Efficient Tool for in Vivo Screening of Protein Farnesylation Inhibitors

We describe the development of a cell system for in vivo screening of inhibitors of the mevalonate pathway. To this aim, we have constructed a bicistronic mRNA, transcribed from a constitutive cytomegalovirus promoter, containing the Renilla reniformis luciferase RNA open reading frame sequence as first cistron and the Firefly luciferase RNA sequence as a second cistron. The intercistronic space is made of the R17 binding sequence of the bacteriophage R17 protein. A chimeric protein able to bind to a specific sequence in the hairpin and to induce internal ribosome entry in the RNA switches on translation of the second cistron. This chimeric protein is made up of the bacteriophage RNA binding domain (R17) fused to the ribosome recruitment core of the eIF-4G1 eukaryotic translation initiation factor and to the CAAX box of H-Ras addressing the protein to the plasma membrane where it is not efficient. Internal ribosome entry upstream of the Firefly cistron is therefore under the dependence of the mevalonate pathway inhibitors. Indeed, products that are able to inhibit protein farnesylation rescue the cytoplasmic location of the R17-eIF-4G-CAAX protein, which once more becomes a translation factor for the expression of the second cistron. To exemplify the system, the present work checks the ability of various antiestrogens to interfere with the mevalonate pathway. It seems that pure antiestrogen, able to selectively bind the estrogen receptor, is unable to switch on the second Firefly cistron although selective antiestrogen-binding-site ligands are able to do so.
Nrf2 Modulates Host Defense during Streptococcus pneumoniae Pneumonia in Mice

Nrf2 regulates the transcriptional response to oxidative stress. These studies tested the role of Nrf2 during Streptococcus pneumoniae pneumonia and identified Nrf2-dependent genes and pathways in lung tissue and in recruited neutrophils. Nrf2 null and wild type (WT) mice were studied at 6 and 24 h after instillation of S. pneumoniae or PBS. At 6 h, fewer neutrophils were recruited and the number of bacteria remaining in the lungs tended to be less (p = 0.06) in the Nrf2 null compared with WT mice. In uninfected lungs, 53 genes were already differentially expressed in Nrf2 null compared with WT mouse lungs, and gene sets involved in phagocytosis, Fc receptor function, complement, and Ig regulation are enhanced in PBS-treated Nrf2 null gene profiles compared with those of WT mice. These results suggest that initial host defense is enhanced in Nrf2 null mice, resulting in less recruitment of neutrophils. At 24 h, neutrophil recruitment was greater. The percentages of early apoptotic and late apoptotic/necrotic neutrophils were similar. At increasing inoculum numbers, mortality rates strikingly increased from 15 to 31 and 100% in Nrf2 null mice, whereas all WT mice survived, and Nrf2 null mice had a defect in clearance, particularly at the intermediate dose. The mortality was due to enhanced lung injury and greater systemic response. Gene profiling identified differentially regulated genes and pathways in neutrophils and lung tissue, including those involved in redox stress response, metabolism, inflammation, immunoregulatory pathways, and tissue repair, providing insight into the mechanisms for the greater tissue damage and increased neutrophil accumulation.
Enhanced, robust genetic algorithms for multiview range image registration

We present a new method for precise registration of multiple range images with low overlap based on genetic algorithms (GAs). The proposed method minimizes the alignment error within the common overlap area among a set of views, which is computed by a novel robust evaluation metric, called the surface interpenetration measure. Because they search in a space of transformations, GAs are capable of registering surfaces without need for prealignment, as opposed to methods based on the iterative closest point (ICP) algorithm, the most popular to date. The experimental results confirm that the new method ensures more precise alignments than combined sequential pairwise alignments for multiview registration, providing accurate global alignment among overlapping views.
Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function.

OBJECTIVE To determine whether dehydroepiandrosterone (DHEA) replacement therapy in hypoadrenal women improves performance, muscle protein accretion, and mitochondrial functions. PARTICIPANTS AND METHODS Thirty-three hypoadrenal women were enrolled in the study from May 1, 2002, through May 31, 2003. Twenty-eight completed a 12-week, prospective, randomized, placebo-controlled, crossover study with either daily placebo or 50 mg of DHEA with a 2-week washout period and then crossed over to the other treatment. Body composition, physical performance, whole-body and muscle protein metabolism, and mitochondrial functions were determined. RESULTS Administration of DHEA significantly increased plasma levels of DHEA sulfate, testosterone, and androstenedione but did not change body composition, muscle strength, peak aerobic capacity, and whole-body protein turnover or synthesis rates of mitochondrial, sarcoplasmic, or mixed muscle proteins. Muscle mitochondrial oxidative enzymes and messenger RNA (mRNA) levels of genes encoding mitochondrial proteins and nuclear transcription factors did not change after DHEA administration. However, mRNA levels of muscle myosin heavy chain 1 (P=.004), which determines muscle fiber type, and those of insulinlike growth factor binding proteins 4 and 5 significantly decreased (P=.02 and P=.03, respectively). CONCLUSION Three months of DHEA administration increased DHEA sulfate and androgen levels but had no effect on physical performance, body composition, protein metabolism, or muscle mitochondrial biogenesis in hypoadrenal women. However, lowering of mRNA levels of binding proteins of insulinlike growth factor 1 and myosin heavy chain 1 suggests potential effects of longterm treatment with DHEA on muscle fiber type.
RANKING ENTERPRISES IN TERMS OF COMPETENCES INSIDE REGIONAL PRODUCTION NETWORK

Today's economic crisis has led to bankruptcy of many successful, but usually large-sized enterprises. This brought into question the future of large-sized enterprises. However, the only alternative to large-sized enterprises (LEs) is networking of small and medium-sized enterprises (SMEs) into Regional Production Networks (RPNet). RPNet is non-hierarchical organizational form in which every SME is autonomous. Hence, every SME of production network is capable and wiling to be part of special cooperation inside network called Virtual Enterprise (VE). For each new product a new virtual enterprise is formed from different SMEs. The ques tion is: which SMEs will be part of new virtual enterprise? If it is possible to evaluate SME's comp etences, it is also possible to rank SMEs. Ranking of SMEs according to technical, organizational and human competences is multi-criteria decision analysis (MCDA) problem. So, in this paper PROM ETHEE method is selected to perform a ranking of SMEs.
Cutting Edge: Critical Role for C5aRs in the Development of Septic Lymphopenia in Mice

In the early stages of sepsis, lymphocytes undergo apoptosis, resulting in lymphopenia and immunosuppression. The trigger for septic lymphopenia is unknown. Using the polymicrobial model of murine sepsis, we investigated the role of C5a receptors in septic lymphopenia. In wild-type mice, cecal ligation and puncture resulted in splenocyte apoptosis and significant lymphopenia after 3 d, which was not observed in C5aR1−/− or C5aR2−/− mice. Our data show that mouse neutrophils exposed to recombinant mouse C5a cause release of histones in a dose-dependent and time-dependent manner. Histone levels in spleen were significantly elevated following cecal ligation and puncture but were reduced by the absence of C5aR1. Histones induced significant lymphocyte apoptosis in vitro. Ab-mediated neutralization of histones prevented the development of lymphopenia in sepsis. Together, these results describe a new pathway of septic lymphopenia involving complement and extracellular histones. Targeting of this pathway may have therapeutic benefit for patients with sepsis or other serious illness.
Cellular compatibility of RGD-modified chitosan nanofibers with aligned or random orientation

Aligned and randomly oriented chitosan nanofibers were prepared by electrospinning. The fibers were modified with the RGD cell-adhesive peptide through a heterobifunctional crosslinker containing a segment of poly(ethylene glycol) (PEG). PEG rendered the surface hydrophilic and provided flexible spacers, allowing the preservation of the bioactivity of further captured RGD peptides. NIH 3T3 cells were used to test the cellular compatibility of these chitosan nanofibrous scaffolds. Cell morphology and viability were investigated by SEM, fluorescent staining and cell counting. The results indicate that RGD-modified surfaces significantly improve the cellular compatibility of chitosan nanofibers and suggest a good candidate as a scaffold employed in tissue engineering.
Intracellular measurements in mammary carcinoma cells using fiber-optic nanosensors.

Submicrometer fiber-optic biosensors have been developed and used to measure toxic chemicals within single cells. Optical fibers that have been pulled to a distal-end diameter of less than 1 micrometer are coated with antibodies to selectively bind the species of interest. This paper describes the use of these fibers to selectively measure the concentration of benzo[a]pyrene tetrol (BPT), a metabolite of benzo[a]pyrene, within individual cells of two different cell lines, human mammary carcinoma cells and rat liver epithelial cells. The results from these measurements have been used to determine the sensitivity, reproducibility, and usefulness of these nanosensors. The detection limit of these biosensors has been determined to be 0.64 +/- 0.17 x 10(-11) M for BPT.
Affective Colour Palettes in Visualization

The communication of affect, a feeling or emotion, is central to creating engaging visual experiences. We report research into how different colour properties (lightness, chroma and hue) contribute to different affective impressions in information visualization applications. Our results provide initial evidence that colour properties can be manipulated to achieve affective expressiveness in information visualization.
Quantification of Lung Perfusion Blood Volume by Dual-Energy CT in Patients With and Without Chronic Obstructive Pulmonary Disease

Purpose: In chronic obstructive pulmonary disease (COPD), pulmonary vascular alteration is one of the characteristic features. Recently, software has been used for the quantification of lung iodine perfusion blood volume (iPBV) using dual-energy CT, allowing objective evaluation. The purpose of this study was to evaluate the quantification of lung PBV with and without COPD. Materials and Methods: This study was approved by the Institutional Review Board. Sixty-two subjects who had undergone a respiratory function test within one month underwent dual-energy CT angiography. The subjects were divided into two groups: with (n = 14) and without (n = 48) COPD. We evaluated the quantification of lung iPBV in the early phase and late phase using Syngo softwarepost contrast. Associations between lung iPBV and respiratory function (forced expiratory volume in 1 second/forced vital capacity; FEV1/FVC) and the percentage area of emphysema (%LAA-950) were also evaluated. Results: In the early phase, lung iPBV values were 20.1 ± 5.5 and 30.6 ± 7.6 Hounsfield Unit (HU) in those with and without COPD, respectively, with a significant difference between them (p < 0.0001). In the late phase, the values were 12.3 ± 3.7 and 15.3 ± 4.6 HU, respectively, with no significant difference (p = 0.051). However, this could be noticed as a trend. In the early phase, there was a weak significant correlation between lung iPBV value and FEV1/FVC (R = 0.26, p = 0.047). There were significant and moderate negative correlations between lung iPBV value and %LAA-950 in early and late phases (R = −0.57, p = 0.0002; R = −0.45, p = 0.005, respectively). Conclusions: Quantification of lung iPBV reflects reduced pulmonary perfusion in patients with COPD. It may be useful for objective evaluation of the pulmonary blood flow in patients with COPD.
Measuring The Economic Impact Of Visitors To Sports Tournaments And Special Events

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The ultrasonic attenuation coefficient for human blood plasma in the frequency range of 7-90 MHz

This work presents experimental results of the ultrasound attenuation coefficient of human blood plasma in the frequency range of 7-90 MHz. Measurements were done with a sample of 450 /spl mu/L of plasma immersed in a water bath with the temperature controlled at 36.5/spl deg/C. The results follow the power law frequency dependence with an exponent of 1.43, compatible with the literature results for low frequency. Also, the results indicate a relaxation mechanism in the vicinity of 10 MHz.
The Relationship of Knowledge, Health Value and Health Self-efficacy with Men’s Intentions to Receive the Human Papillomavirus (HPV) Vaccine

The aim of the present study was to determine whether it was possible to predict Human Papillomavirus (HPV) vaccination intentions an Australian male sample. One hundred and twenty one males aged 18 to 26 (M = 22.3, SD = 2.06), completed an online survey assessing HPV-related knowledge, health beliefs and health self-efficacy. HPV knowledge and health self-efficacy were significant independent predictors of vaccine acceptance. A moderating effect was found between HPV knowledge and health self-efficacy. It was concluded that the results of previous research into the predictors of HPV vaccination intentions can largely be applied to an Australian male population.
A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance.

A series of anti-tumor/anti-chelate bispecific antibody formats were developed for pre-targeted radioimmunotherapy. Based on the anti-carcinoembryonic antigen humanized hT84.66-M5A monoclonal antibody and the anti-DOTA C8.2. 5 scFv antibody fragment, this cognate series of bispecific antibodies were radioiodinated to determine their tumor targeting, biodistribution and pharmacokinetic properties in a mouse xenograft tumor model. The in vivo biodistribution studies showed that all the bispecific antibodies exhibited specific high tumor uptake but the tumor targeting was approximately one-half of the parental anti-CEA mAb due to faster blood clearance. Serum stability and FcRn studies showed no apparent reason for the faster blood clearance. A dual radiolabel biodistribution study revealed that the (111)In-DOTA bispecific antibody had increased liver and spleen uptake, not seen for the (125)I-version due to metabolism and release of the radioiodine from the cells. These data suggest increased clearance of the antibody fusion formats by the mononuclear phagocyte system. Importantly, a pre-targeted study showed specific tumor uptake of (177)Lu-DOTA and a tumor : blood ratio of 199 : 1. This pre-targeted radiotherapeutic and substantial reduction in the radioactive exposure to the bone marrow should enhance the therapeutic potential of RIT.
Reproductive performance of lactating dairy cows following oestrus synchronisation with progesterone, oestradiol and prostaglandin.

The ability to synchronise onset of oestrus, and hence the time of breeding and calving, offers potential economic and management benefits to dairy farmers, especially in herds with seasonally concentrated calving patterns. A trial involving 2681 cows in 11 seasonal herds was conducted to evaluate the reproductive performance of lactating dairy cows following oestrus synchronisation with a combination of progesterone, oestradiol and prostaglandin. Cows were randomly assigned within herds to synchronised and control groups, balanced for age, date of calving, body condition and breed. Cows in the synchronised group were treated with an intravaginal progesterone-releasing device containing 1.9 g of progesterone and a gelatin capsule containing 10 mg of oestradiol benzoate 10 days prior to the planned start of the breeding season (Day 0). The device was removed 8 days later on Day -2 and a luteolytic dose of prostaglandin F2alpha was administered 2 days prior to removal of the progesterone-releasing device. Returns to service for cows in the synchronised group were synchronised by inserting a previously used intravaginal device during Days 16-21 after the start of the breeding season. Cows in the control group were left untreated. The percentage of cows being inseminated during the first 5 days was 89.0% for the synchronised group compared to 29.7% for the control group. Compared to cows in the control group, those in the synchronised group had a lower conception rate to the first insemination (52.9% v. 64.3%, p<0.001), a lower conception rate to the second insemination (51.8% v. 62.5%, p<0.001), a higher percentage of empty cows at the end of the breeding season (7.3% v. 5.1%, p<0.05), and more insemination services per pregnancy to artificial insemination (2.0 v. 1.6, p<0.001). There was no difference between the synchronised and control groups in the percentage of cows pregnant to artificial insemination (81.8% v. 85.5%, p>0.10). The mean day of conception from the start of the breeding season was advanced (p>0.0 1) by 1.3 days in synchronised cows (19.9 +/- 0.7 days; mean +/- SEM) compared to control cows (21.2 +/- 0.5 days). It is concluded that the oestrus synchronisation regime used in the present study caused a reduction in fertility, which reduced the potential gains from using such a programme to increase reproductive efficiency in dairy cows.
Accounting accruals, earnings management and future performance of IPOs

This paper investigates the impact of public-listing age on the future operating performance of Iranian firms making initial public offerings (IPOs) during the period 2003 to 2014, and examines whether accounting accruals and earning management contribute to this impact. In addition, return on net operating assets (RNOA), operational accruals (TAC) and the earnings management (EM) of 81 initial public offerings have been calculated, with the aim of helping capital market participants, policy makers, financial analysts and potential investors thorough the findings of this study, in the stock exchange of financial assets and security investment projects. Multivariate linear regression was used in analysing data. We found that, on average, public-listing age and accounting accruals have a direct effect on future operating performance in Iran, and that earning management does play an indirect role on performance.