Miracle-dz/UniFAR-FTUs huggingface dataset:
Tumorigenicity of four optically active bay-region 3,4-diol 1, 2-epoxides and other derivatives of the nitrogen heterocycle dibenz[c,h]acridine on mouse skin and in newborn mice.

The nitrogen heterocycle dibenz[c,h]acridine (DB[c,h]ACR) and the enantiomers of the diastereomeric pair of bay-region 3,4-diol 1, 2-epoxides as well as other bay-region epoxides and dihydrodiol derivatives of this hydrocarbon have been evaluated for tumorigenicity on mouse skin and in the newborn mouse. On mouse skin, a single topical application of 50 or 200 nmol of compound was followed 10 days later by twice-weekly applications of the tumor promoter 12-O:-tetradecanoylphorbol-13-acetate for 20 weeks. DB[c, h]ACR and the four optically pure, bay-region 3,4-diol-1,2-epoxide isomers all had significant tumor- initiating activity. The isomer with (1R,2S,3S,4R) absolute configuration [(+)-DE-2] was the most active diol epoxide isomer. The (-)-(3R,4R)-dihydrodiol of DB[c, h]ACR, the expected metabolic precursor of the bay-region (+)-DE-2, was 4- to 6-fold more tumorigenic than its corresponding (+)-enantiomer. In tumorigenicity studies in newborn mice, a total dose of 70-175 nmol of DB[c,h]ACR or one of its derivatives was injected i.p. on days 1, 8 and 15 of life, and tumorigenic activity was determined when the mice were 36-39 weeks old. DB[c,h]ACR produced a significant number of pulmonary tumors and also produced hepatic tumors in male mice. Of the four optically active bay-region diol epoxides, only (+)-DE-2 and (+)-DE-1 with (1R,2S,3S,4R) and (1S, 2R,3S,4R) absolute configuration, respectively, produced a significant tumor incidence. At an equivalent dose, the (+)-DE-2 isomer produced several-fold more pulmonary tumors and hepatic tumors than the (+)-DE-1 isomer. The (-)-(3R,4R)-dihydrodiol, metabolic precursor of the bay-region (+)-DE-2, was strongly active and induced an equal number of pulmonary and hepatic tumors as did DB[c,h]ACR. The (+)-(3S,4S) dihydrodiol was less active. The bay-region (+)-(1R,2S)-epoxide of 1,2,3,4-tetrahydro DB[c,h]ACR was strongly tumorigenic in newborn mice whereas its (-)-(1S, 2R)-enantiomer was inactive. This contrasts with the data on mouse skin where both enantiomers had substantial tumorigenic activity. In summary, the bay-region (+)-(1R,2S,3S,4R)-3,4-diol 1,2-epoxide of DB[c,h]ACR was the most tumorigenic of the four optically active bay-region diol epoxides of DB[c,h]ACR on mouse skin and in the newborn mouse. These results with a nitrogen heterocycle are similar to earlier data indicating high tumorigenic activity for the R,S,S,R bay-region diol epoxides of several carbocyclic polycyclic aromatic hydrocarbons.
The Macroeconomic Effects of Japan's Unconventional Monetary Policies

Japan is the country with the longest history of implementing unconventional monetary policies, which were first introduced 15 years ago and have since been expanded several times. A case in point is the quantitative and qualitative monetary easing (QQE) policy introduced by the Bank of Japan (BOJ) in early 2013 along with the commitment to continue with the program as long as necessary to achieve a 2% price stability target. This study attempts to assess the overall macroeconomic effects of Japan's unconventional monetary policies, with an emphasis on the recent QQE program. Using a stylized block-recursive vector autoregression (VAR) framework, the analysis suggests that expansionary unconventional monetary policy shocks have clear macroeconomic effects, leading to a persistent rise in real output and inflation in Japan. The evidence also suggests that these macroeconomic effects became larger and more persistent after the introduction of QQE. A formal analysis that allows for a regime shift based on a smooth-transition VAR model supports these findings.
Comparison of the in vitro dissolution behaviour of various indomethacin formulations with their in vivo bioavailability

The effects of the core to colloid wall ratio and particle size of the core on the in vitro release of indomethacin microcapsules prepared by the gelatin‐acacia complex coacervation process have been examined. All formulations showed a zero order release pattern after an initial burst phase. The release rate increased with increasing core to coat ratios and decreasing particle size of core material. In vivo plasma level studies showed no difference in bioavailability between different microcapsule formulations or a conventional indomethacin capsule. In vitro release studies on a commercially available sustained release formulation of indomethacin (Indocid R) were slower than any of the microcapsule formulations and exhibited a √t dependence indicating a diffusion controlled process from a matrix formulation. In vivo studies show this formulation to have a longer, smoother plasma concentration than the microcapsule formulation, and to avoid high initial peak values of drug. Thus from the in vitro studies a sustained release effect was not unexpected but the in vitro differences between the microcapsule products were not paralleled by the in vivo behaviour. These results illustrate some of the problems in extrapolation of in vitro dissolution data to the in vivo situation.
Research on Trust Evaluation Model of Grid Services

In an open grid of services architecture, to reflect service reliability is a major security problem. In this paper a trust evaluation model based on compensation is presented to enhance the reliability and credibility of grid services by evaluating the servicespsila trust value dynamically. For evaluating servicespsila trust, the trust model combines consumerspsila commendatory trust, services access frequency, servicepsilas own assigned trust and the decrease of the trust. Both theoretical analysis and emulation experiments show that the model can make the service providers and service demanders voluntarily discard the intention of cheating and other malicious behaviors, and then promote the creditability of services, simplify the calculating process and reduce the cost of communication. It is a creative solution for identifying reliability of grid services.
Influence of multiple scattering on the measurement of light attenuation by water filled with bubbles

Using a solution of the radiation transfer equation in the small angle approximation, we examine the effect of multiple scattering on the measurement of the light beam attenuation in an aquatic environment abundant in bubbles created by movement of ship or sea animals. According to the measurement condition, the correction coefficient denoting the extent of multiple scattering is introduced, which is a function of detector field of view (FOV), beam transfer distance, beam size and energy-received section size. Given a typical bubble clouds' distribution function, numerical computations and the analysis between the correction coefficient and its four parameters are provided. The results show that the multiple scattering is obvious when measuring the light attenuation by water filled with large numbers of bubbles, and the degree of multiple scattering changes along with measurement parameters.
Informatics Education in Europe: Institutions, Degrees, Students, Positions, Salaries — Key Data 2008-2012

From the beginnings of Informatics Europe (the association of university departments and industrial research labs in computer science in Europe) it was clear that one of the principal tasks would be to collect the facts. The report is one of the first results of this effort. The principal author is Cristina Pereira, who collected and organized the relevant data over more than a year; I helped with the preparation of the final text. Gathering the information is particularly difficult for Europe given the national variations and the absence of centralized statistical data. Even the list of names under which institutions teach informatics in Europe fills a large table in the report. Cristina's decision was, from the start, to favor quality over quantity: to focus on impeccable data for countries for which we could get it, rather than trying to cover the whole continent with data of variable credibility. The result is the first systematic repository of basic information on informatics education in Europe: institutions, degrees offered and numbers awarded, student numbers, position titles and definitions, and salaries for PhD students, postdocs and professors of various ranks.
Development of a Microfabricated Optical Bend Loss Sensor for Distributive Pressure Measurement

A flexible high-resolution sensor capable of measuring the distribution of pressure beneath the foot via a microfabricated optical waveguide system is presented. The uniqueness of the system is in its batch fabrication process, which involves a microfabrication molding technique with polydimethylsiloxane (PDMS) as the optical medium. The sensor manufacturing technique is described in detail, the optical performance of the waveguides is quantified and the effect of using a matching fluid to improve fiber-coupling efficiency is demonstrated. Mechanical loading tests were performed on a 4times4 array with a 2-mm spacing between sensing elements. Loading displacement curves were obtained using a 0 to 0.4 mm triangle loading profile. A force of 0.28 N applied to one of the sensing elements produced a displacement of a 0.325 mm and 39% change in the output light intensity. Multiple loadings were conducted to demonstrate the repeatability of the sensor. A force image algorithm with a two-layer neural network system was used to identify four load magnitudes and four different shaped applicators. All four shapes were successfully identified with the neural network.
Silver-coated nylon dressings for pediatric burn victims

Background Silver dressings are a proven method for burn treatment. Current challenges associated with burn treatment include pain management and limited hospital resources. A new silver-coated nylon dressing was used at the Montreal Children's Hospital (Montreal, Quebec) to help reduce traumatic dressing changes and cost. Methods Burn victims in a pediatric patient population were followed over two years. Patients were excluded if they were evaluated more than 48 h postburn or if the burn affected less than 5% of the total body surface area. The same burn team admitted and treated all case subjects, and one dressing nurse recorded and monitored all progress throughout the study to ensure standardization. Results Fifteen patients were included in the study. The average number of dressing changes needed was 4.13, with a median of three changes. The average total body surface area burned was 8%, with a mean of 13.9 days before superficial wounds were re-epithelialized. The average length of in-hospital stay was four days. The cost was $388 less for silver-coated nylon dressings than for silver sulfadiazine cream for seven days of treatment. Silver-coated nylon dressings did not leave any residue or pseudoeschar on the wounds and were easily maintained at home. Conclusion The silver-coated nylon dressings are as effective as other silver dressings used for pediatric burn victims. The dressings are less traumatic, require fewer resources and do not leave wound residue compared with other dressings.
Association between BDNF val66 met genotype and episodic memory

The val66 met polymorphism of brain derived neurotrophic factor (BDNF) has been associated with variability in episodic memory [Egan et al., 2003 ]. In an attempt to replicate this finding, we genotyped 206 individuals (92 affected with schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for the BDNF val66 met polymorphism. We analyzed the effect of this polymorphism on episodic memory using the Wechsler Memory Scale, revised version (WMS‐R) by regression analysis between the WMS delayed score of logical memory and genotype (corrected for age, sex, and IQ). We found the met66 allele conferred a lower score on the WMS delayed measure (R2 = 0.014 P = 0.09), which was not significant. When cases and unaffected relatives were analyzed separately, met66 was associated with a lower score on the WMS delayed measure in the relatives only (R2 = 0.077 P = 0.01), which is consistent with previous findings. © 2005 Wiley‐Liss, Inc.
A distributed speech recognition system in multi-user environments

A typical distributed speech recognition (DSR) system is a configuration that distributes computational burden in signal processing and pattern recognition between a mobile unit and a remote recognition engine. For this system to be robust and practically acceptable, distortions caused by erroneous data transmission should be minimized. In this paper, the effects of multiple simultaneous users in a wireless network on speech recognition are considered. Specifically, multiple access interference (MAI) is shown to be a significant factor in the recognition performance degradation of a DSR system. From simulation results, both a minimum-mean-square-error (MMSE) detector and a de-correlating filter are shown to be effective in reducing MAI and improving recognition accuracy. In a CDMA system with 6 interferers at an SNR of 7 dB in an AWGN channel, there was a 30% absolute reduction in word-error-rate (WER) for a connected digit recognition task by using an MMSE detector to combat MAI. Almost same results were obtained by using a de-correlating filter.
Monte Carlo verification of polymer gel dosimetry applied to radionuclide therapy: a phantom study

This study evaluates the dosimetric performance of the polymer gel dosimeter ‘Methacrylic and Ascorbic acid in Gelatin, initiated by Copper’ and its suitability for quality assurance and analysis of I-131-targeted radionuclide therapy dosimetry. Four batches of gel were manufactured in-house and sets of calibration vials and phantoms were created containing different concentrations of I-131-doped gel. Multiple dose measurements were made up to 700 h post preparation and compared to equivalent Monte Carlo simulations. In addition to uniformly filled phantoms the cross-dose distribution from a hot insert to a surrounding phantom was measured. In this example comparisons were made with both Monte Carlo and a clinical scintigraphic dosimetry method. Dose-response curves generated from the calibration data followed a sigmoid function. The gels appeared to be stable over many weeks of internal irradiation with a delay in gel response observed at 29 h post preparation. This was attributed to chemical inhibitors and slow reaction rates of long-chain radical species. For this reason, phantom measurements were only made after 190 h of irradiation. For uniformly filled phantoms of I-131 the accuracy of dose measurements agreed to within 10% when compared to Monte Carlo simulations. A radial cross-dose distribution measured using the gel dosimeter compared well to that calculated with Monte Carlo. Small inhomogeneities were observed in the dosimeter attributed to non-uniform mixing of monomer during preparation. However, they were not detrimental to this study where the quantitative accuracy and spatial resolution of polymer gel dosimetry were far superior to that calculated using scintigraphy. The difference between Monte Carlo and gel measurements was of the order of a few cGy, whilst with the scintigraphic method differences of up to 8 Gy were observed. A manipulation technique is also presented which allows 3D scintigraphic dosimetry measurements to be compared to polymer gel dosimetry measurements without generating misleading errors due to the limited spatial resolution.
Data Envelopment Analysis with Fixed Inputs, Undesirable Outputs and Negative Data

In Data Envelopment Analysis (DEA), different models have been measured to evaluate the performance of decision making units with multiple inputs and outputs. Revised model of Slack-based measures known as MBSM of collective models family has been introduced by Sharp et al. Slack-based measure has been introduced by Ton. In this study, a model is proposed that is able to estimate the efficiency when a number of outputs of decision making units are undesirable, inputs are fixed and some of outputs and inputs are negative. So that, level of undesirable output is reduced at the constant level of inputs in the evaluation unit and by conserving the efficiency.
Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase

Terminal deoxynucleotidyl transferase (TdT; EC 2.7.7.31) adds nucleotides to DNA ends generated during V(D)J recombination that are subsequently processed by proteins involved in general double-strand break (DSB) repair pathways. We report an association between TdT and a 55-kDa protein in lymphoid cells. This protein, identified as hPso4, is a homolog of the protein encoded by the PS04/PRP19 gene in Saccharomyces cerevisiae that has pleiotropic functions in DNA recombination and error-prone repair. Purified hPso4 binds double-stranded DNA in a sequence-nonspecific manner but does not bind single-stranded DNA. hPso4 protein is induced 15- to 30-fold in cells by γ radiation and chemical mutagens but not by UV treatment. Loss of hPso4 expression induced by siRNA results in accumulation of DSBs, apoptosis, and decreased cell survival after DNA damage. We conclude that hPso4 plays a major and previously undefined role in mammalian DNA DSB repair.
Heritability variations of morphometric traits in West Bengal (India) children aged 4–19 years: A mixed-longitudinal growth study

Background: Longitudinal and semi-longitudinal growth studies on siblings reflecting heritability changes during growth are very scarce. Moreover, studies of variables other than height, weight and BMI are virtually non-existent. Aim: The study compared changes in the heritability of six body lengths, four body breadths, and three indices between ages 4 and 19 years on the basis of a mixed-longitudinal sample of siblings, and examined whether heritability estimates change during the growth period. The data consisted of 238 brothers and 214 sisters from 134 middle-class nuclear families living in Kolkata (India). The analysis of sibling correlation was performed by maximum likelihood. The age-related patterns of heritabilities of the various traits were described by a cubic spline. Results: The heritability was very high and significant in most traits, and at all considered ages. Mean heritability in the 10 morphometric traits was 69.3%, which was higher than the heritability values for the three indices. Conclusions: These results confirmed the existence of age-related trends in heritability of the considered morphometric traits. The sharp decline of the heritabilities at adolescence in most of the morphometric traits, and the acromio-iliac index in particular, may be due to the large inter-individual variation in the age at which the adolescent growth spurt is reached in both sexes.
Development of Continuous Cell Culture of Brown Planthopper To Trace the Early Infection Process of Oryzaviruses in Insect Vector Cells

ABSTRACT Rice ragged stunt virus (RRSV), an oryzavirus in the family Reoviridae, is transmitted by the brown planthopper, Nilaparvata lugens, in a persistent-propagative manner. Here, we established a continuous cell line of brown planthopper to investigate the mechanism underlying the formation of the viroplasm, the putative site for viral replication and assembly, during infection of RRSV in its insect vector cells. Within 24 h of viral infection of cultured cells, the viroplasm had formed and contained the viral nonstructural proteins Pns6 and Pns10, known to be constituents of viroplasm. Core capsid protein P3, core particles, and newly synthesized viral RNAs were accumulated inside the viroplasm, while outer capsid protein P8 and virions were accumulated at the periphery of the viroplasm, confirming that the viroplasm induced by RRSV infection was the site for viral replication and assembly. Pns10 formed viroplasm-like inclusions in the absence of viral infection, suggesting that the viroplasm matrix was largely composed of Pns10. Pns6 was recruited in the viroplasm by direct interaction with Pns10. Core capsid protein P3 was recruited to the viroplasm through specific association with Pns6. Knockdown of Pns6 and Pns10 expression using RNA interference inhibited viroplasm formation, virion assembly, viral protein expression, and viral double-stranded RNA synthesis. Thus, the present study shows that both Pns6 and Pns10 of RRSV play important roles in the early stages of viral life cycle in its insect vector cells, by recruiting or retaining components necessary for viral replication and assembly. IMPORTANCE The brown planthopper, a commonly distributed pest of rice in Asia, is the host of numerous insect endosymbionts, and the major vector of two rice viruses (RRSV and rice grassy stunt virus). For the first time, we successfully established the continuous cell line of brown planthopper. The unique uniformity of brown planthopper cells in the monolayer can support a consistent, synchronous infection by endosymbionts or viral pathogens, improving our understanding of molecular insect-microbe interactions.
Globalization and Outward Foreign Direct Investment

ABSTRACT While recent research into foreign direct investment (FDI) has focused on examining the importance of institutions, corruption, money laundering, and tax havens, the role of globalization on FDI has not yet been explored. This research investigates the impacts of globalization on outward FDI. We find that both overall globalization and its economic and social dimensions significantly positively influence outward FDI flows. We also demonstrate that beyond the level of globalization, corruption, money laundering, and the status of a country as a tax haven, cross-country similarity also plays an important role. Accordingly, policies specifically designed to increase the transparency of outward FDI flows should be required to address money laundering and the existence of tax havens.
Technical Efficiency of the Vietnamese Banking Sector: An Empirical Analysis Encompassing Pre- and Post-WTO Entry

University of Wollongong Copyright Warning You may print or download ONE copy of this document for the purpose of your own research or study. The University does not authorise you to copy, communicate or otherwise make available electronically to any other person any copyright material contained on this site. You are reminded of the following: This work is copyright. Apart from any use permitted under the Copyright Act 1968, no part of this work may be reproduced by any process, nor may any other exclusive right be exercised, without the permission of the author. Copyright owners are entitled to take legal action against persons who infringe their copyright. A reproduction of material that is protected by copyright may be a copyright infringement. A court may impose penalties and award damages in relation to offences and infringements relating to copyright material. Higher penalties may apply, and higher damages may be awarded, for offences and infringements involving the conversion of material into digital or electronic form. Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.