Miracle-dz/UniFAR-FTUs huggingface dataset:
Commissioning of a dedicated commercial Co‐60 total body irradiation unit

Abstract We describe the commissioning of the first dedicated commercial total body irradiation (TBI) unit in clinical operation. The Best Theratronics GammaBeam 500 is a Co‐60 teletherapy unit with extended field size and imaging capabilities. Radiation safety, mechanical and imaging systems, and radiation output are characterized. Beam data collection, calibration, and external dosimetric validation are described. All radiation safety and mechanical tests satisfied relevant requirements and measured dose distributions meet recommendations of American Association of Physicists in Medicine (AAPM) Report #17. At a typical treatment distance, the dose rate in free space per unit source activity using the thick flattening filter is 1.53 × 10−3 cGy*min−1*Ci−1. With a 14,000 Ci source, the resulting dose rate at the midplane of a typical patient is approximately 17 and 30 cGy/min using the thick and thin flattening filters, respectively, using the maximum source to couch distance. The maximum useful field size, defined by the 90% isodose line, at this location is 225 × 78 cm with field flatness within 5% over the central 178 × 73 cm. Measured output agreed with external validation within 0.5%. End‐to‐end testing was performed in a modified Rando phantom. In‐house MATLAB software was developed to calculate patient‐specific dose distributions using DOSXYZnrc, and fabricate custom 3D‐printed forms for creating patient‐specific lung blocks. End‐to‐end OSLD and diode measurements both with and without lung blocks agreed with Monte Carlo calculated doses to within 5% and in‐phantom film measurements validated dose distribution uniformity. Custom lung block transmission measurements agree well with design criteria and provide clinically favorable dose distributions within the lungs. Block placement is easily facilitated using the flat panel imaging system with an exposure time of 0.01 min. In conclusion, a novel dedicated TBI unit has been commissioned and clinically implemented. Its mechanical, dosimetric, and imaging capabilities are suitable to provide state‐of‐the‐art TBI for patients as large as 220 cm in height and 78 cm in width.
Virtual Reality as a Tool for Evaluation of Repetitive Rhythmic Movements in the Elderly and Parkinson's Disease Patients

This work presents an immersive Virtual Reality (VR) system to evaluate, and potentially treat, the alterations in rhythmic hand movements seen in Parkinson's disease (PD) and the elderly (EC), by comparison with healthy young controls (YC). The system integrates the subjects into a VR environment by means of a Head Mounted Display, such that subjects perceive themselves in a virtual world consisting of a table within a room. In this experiment, subjects are presented in 1st person perspective, so that the avatar reproduces finger tapping movements performed by the subjects. The task, known as the finger tapping test (FT), was performed by all three subject groups, PD, EC and YC. FT was carried out by each subject on two different days (sessions), one week apart. In each FT session all subjects performed FT in the real world (FTREAL) and in the VR (FTVR); each mode was repeated three times in randomized order. During FT both the tapping frequency and the coefficient of variation of inter-tap interval were registered. FTVR was a valid test to detect differences in rhythm formation between the three groups. Intra-class correlation coefficients (ICC) and mean difference between days for FTVR (for each group) showed reliable results. Finally, the analysis of ICC and mean difference between FTVR vs FTREAL, for each variable and group, also showed high reliability. This shows that FT evaluation in VR environments is valid as real world alternative, as VR evaluation did not distort movement execution and detects alteration in rhythm formation. These results support the use of VR as a promising tool to study alterations and the control of movement in different subject groups in unusual environments, such as during fMRI or other imaging studies.
Effect of Cr Addition on Mechanical Properties and Wear Rate of Cast Al-Cu Alloy

Objectives: This paper investigates the effect of Cr addition on hardness, tensile properties and wear behaviour of Al-4.5Cu alloy A206. Methodology: The base alloy was melted and stirred well, fine Cr powder added in required amount, in oil fired pit furnace and poured into a permanent cast iron mold. The cast specimens were solution heat treated at 540⁰C for 4 hrs and were aged at 170⁰C for 17 hrs and 20 hrs. The as-cast and aged specimens were subjected to microstructure and EDAX evaluation followed by hardness, tensile and wear testing. Findings: The microstructure analysis and EDAX analysis reported an irregularly distributed polyhedral structures that appear blocky due to the phase formation of Al-Cr-Mn-Fe-Si. The hardness, ultimate tensile strength and yield strength were found to increase, reach a peak value and then decrease upon further chromium addition in aged condition. The wear rate decreased with increasing hardness and coefficient of friction remained constant with time. Application/Improvements: Evaluate the effect of Cr in Al alloys on the mechanical strength and wear properties.
Spontaneous Abortion and Preterm Labor and Delivery in Nonhuman Primates: Evidence from a Captive Colony of Chimpanzees (Pan troglodytes)

Background Preterm birth is a leading cause of perinatal mortality, yet the evolutionary history of this obstetrical syndrome is largely unknown in nonhuman primate species. Methodology/Principal Findings We examined the length of gestation during pregnancies that occurred in a captive chimpanzee colony by inspecting veterinary and behavioral records spanning a total of thirty years. Upon examination of these records we were able to confidently estimate gestation length for 93 of the 97 (96%) pregnancies recorded at the colony. In total, 78 singleton gestations resulted in live birth, and from these pregnancies we estimated the mean gestation length of normal chimpanzee pregnancies to be 228 days, a finding consistent with other published reports. We also calculated that the range of gestation in normal chimpanzee pregnancies is approximately forty days. Of the remaining fifteen pregnancies, only one of the offspring survived, suggesting viability for chimpanzees requires a gestation of approximately 200 days. These fifteen pregnancies constitute spontaneous abortions and preterm deliveries, for which the upper gestational age limit was defined as 2 SD from the mean length of gestation (208 days). Conclusions/Significance The present study documents that preterm birth occurred within our study population of captive chimpanzees. As in humans, pregnancy loss is not uncommon in chimpanzees, In addition, our findings indicate that both humans and chimpanzees show a similar range of normal variation in gestation length, suggesting this was the case at the time of their last common ancestor (LCA). Nevertheless, our data suggest that whereas chimpanzees' normal gestation length is ∼20–30 days after reaching viability, humans' normal gestation length is approximately 50 days beyond the estimated date of viability without medical intervention. Future research using a comparative evolutionary framework should help to clarify the extent to which mechanisms at work in normal and preterm parturition are shared in these species.
Parallel Candecomp/Parafac Decomposition of Sparse Tensors Using Dimension Trees

CANDECOMP/PARAFAC (CP) decomposition of sparse tensors has been successfully applied to many problems in web search, graph analytics, recommender systems, health care data analytics, and many other domains. In these applications, efficiently computing the CP decomposition of sparse tensors is essential in order to be able to process and analyze data of massive scale. For this purpose, we investigate an efficient computation of the CP decomposition of sparse tensors and its parallelization. We propose a novel computational scheme for reducing the cost of a core operation in computing the CP decomposition with the traditional alternating least squares (CP-ALS) based algorithm. We then effectively parallelize this computational scheme in the context of CP-ALS in shared and distributed memory environments and propose data and task distribution models for better scalability. We implement parallel CP-ALS algorithms and compare our implementations with an efficient tensor factorization library using tensors form.
Misclassified Samples based Hierarchical Cascaded Classifier for Video Face Recognition

Due to various factors such as postures, facial expressions and illuminations, face recognition by videos often suffer from poor recognition accuracy and generalization ability, since the within-class scatter might even be higher than the between-class one. Herein we address this problem by proposing a hierarchical cascaded classifier for video face recognition, which is a multi-layer algorithm and accounts for the misclassified samples plus their similar samples. Specifically, it can be decomposed into single classifier construction and multi-layer classifier design stages. In single classifier construction stage, classifier is created by clustering and the number of classes is computed by analyzing distance tree. In multi-layer classifier design stage, the next layer is created for the misclassified samples and similar ones, then cascaded to a hierarchical classifier. The experiments on the database collected by ourselves show that the recognition accuracy of the proposed classifier outperforms the compared recognition algorithms, such as neural network and sparse representation.
Early Developmental Responses to Seedling Environment Modulate Later Plasticity to Light Spectral Quality

Correlations between developmentally plastic traits may constrain the joint evolution of traits. In plants, both seedling de-etiolation and shade avoidance elongation responses to crowding and foliage shade are mediated by partially overlapping developmental pathways, suggesting the possibility of pleiotropic constraints. To test for such constraints, we exposed inbred lines of Impatiens capensis to factorial combinations of leaf litter (which affects de-etiolation) and simulated foliage shade (which affects phytochrome-mediated shade avoidance). Increased elongation of hypocotyls caused by leaf litter phenotypically enhanced subsequent elongation of the first internode in response to low red∶far red (R∶FR). Trait expression was correlated across litter and shade conditions, suggesting that phenotypic effects of early plasticity on later plasticity may affect variation in elongation traits available to selection in different light environments.
Hippo‐yap signaling in ocular development and disease

The Hippo‐Yes associated protein (Yap) pathway plays an important role in organ size control by regulating cell proliferation, apoptosis, and stem cell renewal. Hippo‐Yap signaling also functions at the level of cellular development in a variety of organs through its effects on cell cycle control, cell survival, cell polarity, and cell fate. Because of its important roles in normal development and homeostasis, abnormal regulation of this pathway has been shown to lead to pathological outcomes such as tissue overgrowth, tumor formation, and abnormal organogenesis, including ocular‐specific disorders. In this review, we summarize how normal and perturbed control of Yap signaling is implicated in ocular development and disease Developmental Dynamics 247:794–806, 2018. © 2018 Wiley Periodicals, Inc.
Asean-5+3 And Us Stock Markets Interdependence Before, During And After Asian Financial Crisis

The issues of international stock markets linkages had been investigated over the time. Since the Asian financial crisis in 1997, many economists are concerned about the relationship between Asian stock markets and others in the world. This paper is conducted to examine the linkages between ASEAN-5+3 namely Malaysia, Singapore, the Philippines, Thailand, Indonesia, China, Japan and Korea and US stock markets. The data consists of weekly stock indices data. The total samples are separated into three subperiods. First period is pre-crisis period spanning from January 1990 to June 1997. Second period is during-crisis period spanning from July 1997 to June 1998. Third period is post-crisis period spanning from July 1998 to May 2007. All the indices applied are expressed in local currencies. The empirical analysis begins with testing the stationarity properties of the data. All the countries are found to be stationary at first difference except for Japan for pre-crisis period. Next, cointegration test is employed to test the long-run stationary relationship among the stock markets. The number of significant cointegrating vector is higher during-crisis compare to other periods whereas the same number of cointegrating vector is found before and after crisis. Granger-causality based on VECM showed that Thailand is exogenous whereby Malaysia is the most endogenous at before and during the crisis. After the crisis, US become dominant compare to the other countries. In conclusion, we found that ASEAN- 5+3 and US stock markets are interdependence during crisis and post-crisis periods and the impact of US stock market is effective in ASEAN-5+3 stock markets only for pre and during-crisis periods
Participatory approaches to workplace safety management: bridging the gap between behavioral safety and participatory ergonomics

Many researchers and practitioners argue the importance of end-user involvement in workplace safety management, but the research literature and practices remain fractured across orientations. The primary aim of this article is to bridge the gap between two major participatory safety management approaches: behavioral safety and participatory ergonomics. First, an overview and brief history of participative management is presented to provide context for its application to workplace safety. Next, behavioral safety and participatory ergonomics are separately examined in terms of their origins and core elements. Finally, based on this examination, unifying elements between behavioral safety and participatory ergonomics will be presented to provide a comprehensive account of participatory safety management.
Low‐frequency noise analysis and minimization in Gilbert‐cell‐based mixers for direct‐conversion (zero‐IF) low‐power front‐ends

Low‐frequency (flicker) noise is one of the most important issues in the design of direct‐conversion zero‐IF front‐ends. Within the front‐end building blocks, the direct‐conversion mixer is critical in terms of flicker noise, since it performs the signal down‐conversion to baseband. This paper analyzes the main sources of low‐frequency noise in Gilbert‐cell‐based direct‐conversion mixers, and several issues for minimizing the flicker noise while keeping a good mixer performance in terms of gain, noise figure and power consumption are introduced in a quantitative manner. In order to verify these issues, a CMOS Gilbert‐cell‐based zero‐IF mixer has been fabricated and measured. A flicker noise as low as 10.4 dB is achieved (NF at 10 kHz) with a power consumption of only 2 mA from a 2.7 V power supply. More than 14.6 dB conversion gain and noise figure lower than 9 dB (DSB) are obtained from DC to 2.5 GHz with an LO power of −10 dBm, which makes this mixer suitable for a multi‐standard low‐power zero‐IF front‐end. Copyright © 2008 John Wiley & Sons, Ltd.
Reprogramming the Transcriptional Response to Hypoxia with a Chromosomally Encoded Cyclic Peptide HIF-1 Inhibitor

The cellular response to hypoxia is orchestrated by HIF-1, a heterodimeric transcription factor composed of an α and a β subunit that enables cell survival under low oxygen conditions by altering the transcription of over 300 genes. There is significant evidence that inhibition of HIF-1 would be beneficial for cancer therapy. We recently reported a cyclic hexapeptide that inhibits the HIF-1α/HIF-1β protein–protein interaction in vitro and prevents HIF-1-mediated hypoxia-response signaling in cells. This cyclic peptide was identified from a library of 3.2 × 106 members generated using SICLOPPS split-intein mediated protein splicing. With a view to demonstrating the potential for encoding the production of a therapeutic agent in response to a disease marker, we have engineered human cells with an additional chromosomal control circuit that conditionally encodes the production of our cyclic peptide HIF-1 inhibitor. We demonstrate the conditional production of our HIF-1 inhibitor in response to hypoxia, and its inhibitory effect on HIF-1 dimerization and downstream hypoxia-response signaling. These engineered cells are used to illustrate the synthetic lethality of inhibiting HIF-1 dimerization and glycolysis in hypoxic cells. Our approach not only eliminates the need for the chemical synthesis and targeted delivery of our HIF-1 inhibitor to cells, it also demonstrates the wider possibility that the production machinery of other bioactive compounds may be incorporated onto the chromosome of human cells. This work demonstrates the potential of sentinel circuits that produce molecular modulators of cellular pathways in response to environmental or cellular disease stimuli.
Motion of Vortices in Type II Superconductors

The methods of formal asymptotics are used to examine the behaviour of a system of curvilinear vortices in a type II superconductor as the thickness of the vortex cores tends to zero. The vortices then appear as singularities in the field equation and are analagous to line vortices in inviscid hydrodynamics. A local analysis near each vortex core gives an equation of motion governing the evolution of these singularities.
Anaplastic Sarcoma of the Kidney

We present a case of an extremely rare and relatively new tumor entity of the kidney, the anaplastic sarcoma. Although of unknown origin and pathogenesis, treating such a tumor as if it was anaplastic Wilms' tumor seems to be the only therapeutic solution at the present time. Newer immunohistochemical staining and molecular probes should be applied to this neoplasm in order for us to understand it nature and maximize therapy.
Detection of Resistance Mutations to Antivirals Oseltamivir and Zanamivir in Avian Influenza A Viruses Isolated from Wild Birds

The neuraminidase (NA) inhibitors oseltamivir and zanamivir are the first-line of defense against potentially fatal variants of influenza A pandemic strains. However, if resistant virus strains start to arise easily or at a high frequency, a new anti-influenza strategy will be necessary. This study aimed to investigate if and to what extent NA inhibitor–resistant mutants exist in the wild population of influenza A viruses that inhabit wild birds. NA sequences of all NA subtypes available from 5490 avian, 379 swine and 122 environmental isolates were extracted from NCBI databases. In addition, a dataset containing 230 virus isolates from mallard collected at Ottenby Bird Observatory (Öland, Sweden) was analyzed. Isolated NA RNA fragments from Ottenby were transformed to cDNA by RT-PCR, which was followed by sequencing. The analysis of genotypic profiles for NAs from both data sets in regard to antiviral resistance mutations was performed using bioinformatics tools. All 6221 sequences were scanned for oseltamivir- (I117V, E119V, D198N, I222V, H274Y, R292K, N294S and I314V) and zanamivir-related mutations (V116A, R118K, E119G/A/D, Q136K, D151E, R152K, R224K, E276D, R292K and R371K). Of the sequences from the avian NCBI dataset, 132 (2.4%) carried at least one, or in two cases even two and three, NA inhibitor resistance mutations. Swine and environmental isolates from the same data set had 18 (4.75%) and one (0.82%) mutant, respectively, with at least one mutation. The Ottenby sequences carried at least one mutation in 15 cases (6.52%). Therefore, resistant strains were more frequently found in Ottenby samples than in NCBI data sets. However, it is still uncertain if these mutations are the result of natural variations in the viruses or if they are induced by the selective pressure of xenobiotics (e.g., oseltamivir, zanamivir).
In vivo measurements of bone-seeking radionuclides. Progress report, September 1, 1977--February 28, 1979

Progress is reported on the following research projects: estimation of the skeletal burden of bone-seeking radionuclides from in vivo scintillation measurements of their content in the skull; contribution from radionuclides in the thoracic skeleton to in vivo measurements of activity in the lung; design and optimization characterictics of in vivo detection system; development of a calibration phantom structure for determining activity deposited in the thoracic skeleton; computer assisted in vivo measurements of internally deposited radionuclides using dual-crystal scintillation detectors; low energy, photon-emitting nuclides; reference spectra library; and in vivo measurements of exposed individuals. (HLW)
Functionalization of Silicon Nanowires for Specific Sensing

Thanks to their large surface-to-volume ratio, silicon nanowires (Si NWs) are extremely sensitive to all phenomena which could alter their surface potential and charge distribution. Those surface variations lead to a change of the Si NWs equivalent conductance. The use of the output conductance of a silicon nanowire as a compact transducer for direct detection of (bio)chemical molecules or gases has gained immense attention these last years. In this paper, fabrication of silicon nanowires using top-down approach is shown, with simple calculations to determine hole mobility, hole concentration and resistivity. Transfer characteristics and sampling measurements were performed on the nanowires with and without surface functionalization under various ambient conditions indicating the importance of functionalization in order to avoid any environment effect on the transport properties of the nanowires.
The complete mitochondrial genome of the Cavia aperea

Abstract Cavia aperea which is a Brazilian guinea pig is found in the South America. Recently the genome sequencing of C. aperea was done, but no more information of its mitochondrial had been reported. Herein, we assembled the complete mitochondrial genome sequence of C. aperea. It is a 16 835 bp long sequence with most mitogenome’s characteristic structure; 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes, 1 D-loop region, 1 repeat region and 3 STS regions. The GC-content of our fresh sequence is 39%. It can verify the accuracy and utility of newly determined mitogenome sequences by the phylogenetic analysis, based on whole mitogenome alignment with C. porcellus, which is the closest relative to C. aperea. We expect that using the full mitogenome we can address the taxonomic issues and study the related the evolution events.
Image retrieval via generalized I-divergence in the bag-of-visual-words framework

The focus of this work is on the use of Generalized I-Divergence (GID) applied to content-based image retrieval from a real scenes database using the Bag-of-Visual-Words (BoVW) in three different approaches: BoVW, BoVW with the Binary Saliency Map (BSM) and BoVW with the Fuzzy Image Saliency Map (FISM). The BoVW approach has shown a promising performance within the context of the image retrieval, where in general, the similarity between two images is typically measured by the distance between the two histograms using the cosine similarity measure. In this work we use Divergence measures to rank similar images instead of cosine measure with the aim of improving the performance of the methods. Experimental results from two real world image databases have shown that our approach achieved the best precision rates when compared to the use of cosine similarity, particularly on queries with poor initial recall where the traditional cosine distance fails to measure the similarity between the hyperplanes which represent the query image features and the database image features.