Miracle-dz/UniFAR-FTUs huggingface dataset:
Best Place of Care for Older People after Acute and during Subacute Illness: A Systematic Review

Objectives: To assess the evaluative research literature on the costs, quality and effectiveness of different locations of care for older patients. Methods: A systematic review of evaluative research from 1988 using CRD4 guidelines. Twenty-five databases were searched, using processes developed specially for this review. Library OPACS, the Internet and research registers were also searched for relevant material. The final stage of the review was confined to randomised and pseudo-randomised trials. Studies were selected for review by pairs of researchers working independently who then met to reach a decision. Analysis was predominantly descriptive; simple pooled odds ratios were used to explore some outcomes. Results: Eighty-four papers from 45 trials were included. Firm conclusions were difficult to draw, except in relation to some outcomes for stroke units, early discharge schemes and geriatric assessment units. Few trials in this area have adequately addressed issues of patients' quality of life and costs to health services, social care providers, patients and their families. Conclusions: Despite considerable recent development of different forms of care for older patients, evidence about effectiveness and costs is weak. However, evidence is also weak for longer-standing care models. A substantial service evaluation agenda emerges from this review. This study also raises questions about the usefulness of systematic review techniques in the area of service delivery and organisation.
Suppression of Nocturnal Plasma Melatonin and 6-Sulphatoxymelatonin by Bright and Dim Light in Man

Previous studies have shown that bright light (2500 lux) suppresses nocturnal secretion of melatonin, while dim light (500 lux) has little or no effect. We have studied the effect of varying intensities of light on 5 normal male volunteers (age 18-28). The experiment was divided into 3 parts which took place at weekly intervals. Subjects remained under artificial light (fluorescent strip 150-250 lux) between 2000 h-2300 h, they then retired to bed in darkness. On each occasion, between 0030 h and 0100 h, the subjects were required to get up and were treated with light of different intensities; (a) less than 1 lux, (b) 300 lux and (c) 2500 lux respectively. Subjects returned to bed in darkness until 0700 h. Blood was sampled hourly from 2000 h-1000 h with additional samples at 2330 h, 0015 h, 0030 h, 0045 h, 0115 h and 0130 h. Plasma melatonin and 6-sulphatoxymelatonin (aMT6s), the major melatonin metabolite, were measured by radioimmunoassay. Dim (300 lux) and bright (2500 lux) light, both significantly suppressed melatonin levels compared to less than 1 lux (P less than 0.05 and P less than 0.01 respectively) at the following time points 0100 h, 0115 h and 0130 h. One subject did not show suppression with 300 lux. There was also a significant suppression of aMT6s levels, compared to less than 1 lux, after both 300 lux and 2500 lux at 0115 h (P less than 0.05, P less than 0.01), 0130 h (P less than 0.01, P less than 0.01) and 0200 h (P less than 0.01, P less than 0.001) respectively. (ABSTRACT TRUNCATED AT 250 WORDS)
Theory of mind and rule use in individuals with Down's syndrome: a test of the uniqueness and specificity claims.

The relationship between Theory of Mind (ToM) and rule use was explored in adults with Down's Syndrome (DS) and in non-handicapped pre-schoolers. Twelve low-functioning individuals with DS (mean mental age = 5.1 years, mean chronological age = 22.7) performed worse than 12 MA-matched non-handicapped children (mean MA = 5.1 years) on several standard ToM tasks and on a color-shape card-sorting task in which subjects were required to switch between two incompatible sets of rules. On the ToM tasks, people with DS tended to focus on a single state of affairs (e.g. the present situation). Likewise, on the card sort, these subjects tended to use a single set of rules on all trials. Performance in the two types of task was positively correlated when MA was partialed out. The results are inconsistent with the slaim that ToM reflects a domain-specific psychological function and the notion that deficits in ToM are unique to individuals with autism.
The International Database of Efficient Appliances (IDEA): A New Resource for Global Efficiency Policy

Author(s): Gerke, Brian F; McNeil, Michael A; Tu, Thomas; Xu, Feiyang | Abstract: A major barrier to effective appliance efficiency program design and evaluation is a lack of data for determination of market baselines and cost-effective energy savings potential. The data gap is particularly acute in developing countries, which may have the greatest savings potential per unit GDP. To address this need, we are developing the International Database of Efficient Appliances (IDEA), which automatically compiles data from a wide variety of online sources to create a unified repository of information on efficiency, price, and features for a wide range of energy-consuming products across global markets. This paper summarizes the database framework and demonstrates the power of IDEA as a resource for appliance efficiency research and policy development. Using IDEA data for refrigerators in China and India, we develop robust cost-effectiveness indicators that allow rapid determination of savings potential within each market, as well as comparison of that potential across markets and appliance types. We discuss implications for future energy efficiency policy development.
Investigation of Mixing Structure in The Near Field of A Jet in Crossflow

The mixing structure in the near field of a jet in crossflow is investigated. Experiment is performed using the combination of smoke fluid condensation, Mie scattering, and laser-sheet visualization techniques. A series of planar laser-sheet visualization images in the planes perpendicular to the jet exit are taken. The instantaneous images as well as the statistics of the images are then analyzed, and the three-dimensional mean mixing structures are reconstructed. The jet to crossflow effective velocity ratio is 4; the jet and crossflow Reynolds numbers are 14,000 and 5,400, respectively. The instantaneous images show three dominant instantaneous mixing structures: (1) the cascading azimuthal Kelvin-Helmholtz (K-H) mixing structures around the jet column, (2) the leeward vortical roll ups, and (3) the windward vortical roll ups. The cascading K-H structures are initiated and develop early on near the leading edge on the windward side of the jet column. These structures are responsible for the mixing in the very near field region and lead to concentriccylinder three-dimensional mean mixing structure. Further away, the windward vortical roll ups – as opposed to the leeward ones – predominantly govern entrainment and mixing and lead to cascading ellipsoidal three-dimensional mean mixing structures and the development of the familiar kidney-shaped mean structure.
Biodesulfurization of Flue Gases and Other Sulfate/Sulfite Waste Streams Using Immobilized Mixed Sulfate‐Reducing Bacteria

Sulfur dioxide (SO2) is one of the major pollutants in the atmosphere that cause acid rain. Microbial processes for reducing SO2 to hydrogen sulfide (H2S) have previously been demonstrated by utilizing mixed cultures of sulfate‐reducing bacteria (SRB) with municipal sewage digest as the carbon and energy source. To maximize the productivity of the bioreactor for SO2 reduction in this study, various immobilized cell bioreactors were investigated: a stirred tank with SRB flocs and columnar reactors with cells immobilized in either κ‐carrageenan gel matrix or polymeric porous BIO‐SEP beads. The maximum volumetric productivity for SO2 reduction in the continuous stirred‐tank reactor (CSTR) with SRB flocs was 2.1 mmol of SO2/(h·L) . The κ‐carrageenan gel matrix used for cell immobilization was not durable at feed sulfite concentrations greater than 2000 mg/L (1.7 mmol/(h·L) ) . A columnar reactor with mixed SRB cells that had been allowed to grow into highly stable BIO‐SEP polymeric beads exhibited the highest sulfite conversion rates, in the range 16.5 mmol/(h·L) (with 100% conversion) to 20 mmol/(h·L) (with 95% conversion) . The average specific activity for sulfite reduction in the column, in terms of dry weight of SRB biomass, was 9.5 mmol of sulfite/(h·g) . In addition to flue gas desulfurization, potential applications of this microbial process include the treatment of sulfate/sulfite‐laden wastewater from the pulp and paper, petroleum, mining, and chemical industries.
Cooperative Fuzzy Model-Predictive Control

In this paper, a cooperative fuzzy model-predictive control (CFMPC) is presented. The overall nonlinear plant is assumed to consist of several parallel input-coupled Takagi-Sugeno (T-S) fuzzy models. Each such T-S fuzzy subsystem is represented in the form of a local linear model network (LLMN). The control of each local linear model in each LLMN is realized by model-predictive control (MPC). For each LLMN, the outputs of the associated MPCs are blended by the fuzzy membership functions, which leads to a fuzzy model-predictive controller (FMPC). The resulting structure is one FMPC for each LLMN subsystem. Overall, a parallel combination of FMPCs results, which mutually affects all LLMN subsystems by their respective manipulated variables. To compensate detrimental cross-couplings in this setup, a cooperation between the FMPCs is introduced. For this cooperation, convergence is proven, and for the closed-loop system, a stability proof is given. It is demonstrated in a simulation example that the proposed input-constraint CFMPC algorithm achieves convergence of the fuzzy LLMNs within few cooperative iteration steps. Simulations are given to demonstrate the effectiveness of the theoretical results.
A Fully Integrated 10-Gb/s Receiver With Adaptive Optical Dispersion Equalizer in 0.13-$\mu{\hbox {m}}$  CMOS

A 10 Gb/s receiver, containing an adaptive equalizer, a clock and data recovery, and a de-multiplexer, is implemented in 0.13-mum CMOS. The chip is intended for long-haul optical fiber links where chromatic and polarization mode dispersions are reach-limiting factors. The equalization is performed by a continuous time filter and a two-tap decision feedback equalizer while automatic threshold and phase adjustments are embedded in the CDR. Use of an analog equalizer with digital adaptation garners total power dissipation of 950 mW. Error-free operation over 200 km of single mode fiber is demonstrated. With 140 km of single mode fiber, optical signal to noise ratio penalty is only 2dB. Differential group delay of 100 ps can also be tolerated
Structural insights into recognition of acetylated histone ligands by the BRPF 1 bromodomain

Bromodomain-PHD finger protein 1 (BRPF1) is part of the MOZ HAT complex and contains a unique combination of domains typically found in chromatin-associated factors, which include plant homeodomain (PHD) fingers, a bromodomain and a proline-tryptophan-tryptophan-proline (PWWP) domain. Bromodomains are conserved structural motifs generally known to recognize acetylated histones, and the BRPF1 bromodomain preferentially selects for H2AK5ac, H4K12ac and H3K14ac. We solved the X-ray crystal structures of the BRPF1 bromodomain in complex with the H2AK5ac and H4K12ac histone peptides. Site-directed mutagenesis on residues in the BRPF1 bromodomain-binding pocket was carried out to investigate the contribution of specific amino acids on ligand binding. Our results provide critical insights into the molecular mechanism of ligand binding by the BRPF1 bromodomain, and reveal that ordered water molecules are an essential component driving ligand recognition. Structured summary of protein interactions: BRPF1 and H4K12ac bind by x-ray crystallography (View interaction) BRPF1 and H2AK5ac bind by x-ray crystallography (View interaction) H4K12ac and BRPF1 bind by isothermal titration calorimetry (1, 2, 3, 4, 5, 6, 7) H2AK5ac and BRPF1 bind by isothermal titration calorimetry (1, 2, 3, 4, 5, 6, 7) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
A digital wideband CDR with ±15.6kppm frequency tracking at 8Gb/s in 40nm CMOS

It has been well understood that the digital clock and data recovery (CDR) architecture has many system merits over the analog counterpart for multi-Gb/s transceivers [1]. However, the applications have been limited in systems where the clock is forwarded or has small frequency offset [2, 3], due to the finite frequency and jitter tracking capability of the digitally controlled phase rotation. Recently, tracking range up to ±7800ppm has been reported [4] to extend the applications to the SATA/SAS interfaces that require 5000ppm spread spectrum clocking (SSC) to suppress electromagnetic emissions. To enable broad acceptance in high-speed applications, the digital CDRs must have much wider tracking range.
A generative model of urban activities : simulating a population

This work presents a data-driven generative model of a social network in a city. It takes both mobility and social context into account by building a generative process of establishing social connections that is governed by latent profiles of city dwellers. These profiles influence both the community structure of the network as well as preferences in destination choices. Therefore, the model captures an interplay between mobility and the geography of the social network, and can be used to infer social connections from the revealed mobility pattern and vice versa. The model is capable of inferring population profiles and community structure of urban areas from partly observed social network and mobility traces, and could then be applied to simulate a representative sample of the entire population. The results are verified in terms of descriptive statistics of the network structure as well as on the out-of-sample subset of real data collected via Twitter API in San Francisco, CA. General Terms Algorithms, Generative modeling, Networks
Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier

Few markers specific for mouse endothelium exist. We describe here one such marker, MECA‐32, a monoclonal antibody which shows high specificity for mouse endothelium in both embryonic and mature tissues. The MECA‐32 antigen has a Mr of 50−55 − 103 under reducing conditions and Mr of 100−120 − 103 under nonreducing conditions. It is expressed on most endothelial cells in the embryonic and in the adult mouse, with the exception of the brain, skeletal, and cardiac muscle, where it has a more restricted distribution. In skeletal and cardiac muscle only small arterioles and venules express the MECA‐32 antigen, while in the brain its expression is negatively correlated with the differentiation of the vasculature to form the blood brain barrier. Interestingly, during embryonic development the antigen occurs on the brain vasculature up to day 16 of gestation (E16), whereupon it disappears. The embryonic brain is an avascular organ anlage which is vascularized by ingrowth of external blood vessels. Differentiation of the vasculature to form the blood brain barrier occurs at approximately E16 in the mouse. This differentiation correlates with the downregulation of MECA‐32 antigen expression. Between E12 and E16 MECA‐32 detects most endothelial cell surfaces of the blood vessels in the brain. No MECA‐32 antigen is found in the brain at E17 or any later stage of development with the exception of the vasculature of the circumventricular organs. The results suggest that MECA‐32 antigen expression is temporally and spatially correlated with the development of the blood brain barrier. © 1995 Wiley‐Liss, Inc.
Gas exchange threshold in male speed-power versus endurance athletes ages 20-90 years.

PURPOSE This cross-sectional study compared the oxygen uptake at the gas exchange threshold (GET) and its relation to age between highly trained competitive speed-power athletes (SP), endurance athletes, and untrained participants. METHODS A total of 199 men ages 20-90 yr were examined: 51 SP, 87 endurance runners (ER), and 61 untrained individuals (UT). Physiological parameters at GET were obtained during a graded treadmill test until exhaustion: oxygen uptake (V˙O2GET), HRGET, and oxygen pulse (O2 PulseGET). Information about training history and volume was collected. A linear model of regression was adopted. RESULTS Average V˙O2GET was lower in the SP than that in ER group but significantly higher in the SP than that in UT group across the whole age range. Absolute rate of decline in V˙O2GET was smaller in the SP than ER group and smallest in the UT group (0.38, 0.56, and 0.22 mL·kg·min·yr, respectively). Percentage decline per decade did not differ between groups (7.9%-8.7%). Above the age of 50 yr, absolute and percentage rates of decline were considerably lower in the SP than ER group (0.24 vs 0.65 mL·kg·min·yr and 7.2% vs 13.4% per decade, respectively). About the age of 85, the predicted level of V˙O2GET in the SP group was close to that of the ER group. The training volume correlated significantly with V˙O2GET in athletes (r = 0.67-0.70). Main predictors of O2GET were V˙O2 PulseGET and HRGET (89.9%-95.6% and 4.1%-9.8% of explained variance, respectively). CONCLUSIONS Our results suggest that the "speed-power model" of lifelong physical activity is associated with an elevated level of V˙O2GET and its relatively slow age-related decline.
Experimental Study of Reinforced concrete Columns Strengthened with CFRP under Eccentric Loading

This paper presents the results of experimental studies on reinforced concrete columns strengthened with carbon fiber reinforced polymer (CFRP) under the combination of axial load and bending moment. A total of twelve specimens with square cross section (120 mm×120mm) were prepared and tested under eccentric compressive loading up to failure. The overall length of specimens with two haunched heads was 1230 mm. Test parameters were the type of concrete material(Normal and Self-compacting), thickness of layer (CFRP)and the load eccentricity, (eccentricity/ column depth ratio of 0.5 and 1). All specimens are Prepared and tested under eccentric compressive loading up to failure. The effects of these parameters on load-displacement and moment-curvature behaviors of the columns as well as the variation of longitudinal strain on different faces of the columns were studied. The results of the study demonstrated a significant enhancement on the performance of strengthened columns compared to unstrengthened columns.
The effects of Donepezil on traumatic brain injury acute rehabilitation outcomes

Primary objective: To evaluate the effects of administering Donepezil during inpatient rehabilitation for individuals with TBI. Research design: Retrospective, age and injury severity matched, mixed between-within subjects analysis. Methods and procedures: Thirty-six patients with moderate-to-severe TBI admitted to acute rehabilitation within 90 days of injury. Main outcome measures included FIM cognitive total scores and rehabilitation lengths of stay. Intervention: Initiation of Donepezil administration beginning at 5 mg daily. Dose titration and continuation based on perceived clinical response. Main outcomes and results: No differences in cognitive improvement were observed between the Donepezil treatment group and the matched control group. Sub-set analyses suggested that administration of Donepezil early in the rehabilitation stay was significantly related to higher rates of cognitive improvement. Conclusions: Preliminary evidence suggests that Donepezil administration early in the rehabilitation stay may have advantageous treatment effects. A prospective, randomized, placebo-controlled clinical trial with standard timing, dosage and treatment duration is recommended to further evaluate treatment efficacy.
A bis(amine-carboxylate) copper(II) coordination compound forms a two-dimensional metal-organic framework when crystallized from water and methanol.

When {2,2'-[(2-methyl-2-nitropropane-1,3-diyl)diimino]diacetato}copper(II), [Cu(C(8)H(13)N(3)O(6))], (I), was crystallized from a binary mixture of methanol and water, a monoclinic two-dimensional water- and methanol-solvated metal-organic framework (MOF) structure, distinctly different from the known orthorhombic one-dimensional coordination polymer of (I), was isolated, namely catena-poly[[copper(II)-mu(3)-2,2'-[(2-methyl-2-nitropropane-1,3-diyl)diimino]diacetato] methanol 0.45-solvate 0.55-hydrate], {[Cu(C(8)H(13)N(3)O(6))]. 0.45CH(3)OH.0.55H(2)O}(n), (II). The monoclinic structure of (II) comprises centrosymmetric dimers stabilized by a dative covalent Cu(2)O(2) core and intramolecular N-H.O hydrogen bonds. Each dimer is linked to four neighbouring dimers via symmetry-related (opposing) pairs of bridging carboxylate O atoms to generate a ;diamondoid' net or two-dimensional coordination network. Tight voids of 166 A(3) are located between these two-dimensional MOF sheets and contain a mixture of water and methanol with fractional occupancies of 0.55 and 0.45, respectively. The two-dimensional MOF sheets have nanometre-scale spacings (11.2 A) in the crystal structure. Hydrogen-bonding between the methanol/water hydroxy groups and a Cu-bound bridging carboxylate O atom apparently negates thermal desolvation of the structure below 358 K in an uncrushed crystal of (II).
Implementation of Research-Based Learning Model at Indonesian Higher Education to Improve the Quality of Learning Process

Many Indonesian universities have a similar vision of becoming research-based universities or research universities, and one of the missions is to conduct research-based learning (RBL). The study explored to develop the ideal model for RBL through R&D design which involved (1) Research and Information Collecting, (2) Planning, (3) Developing Preliminary Product, (4) Preliminary Field Testing, (5) Main Product Revision, (6) Final Product Revision, (7) Dissemination and Implementation. The data were collected from 25 students and 5 lecturers of Tidar University by means of a questionnaire, and stuffing forms. Field notes were used to record constructive inputs for model development. Observation sheets were used to observe documents of planning, implementation, and evaluation of the learning process. Finally, interviews were conducted with all parties involved in planning, developing, testing and finalizing the model. All the data were then analyzed in accordance with R&D analytical procedures to come up with credibility, dependability, conformability, and transferability of the findings. It turns out that the model of RBL is effective and needs to be fully implemented. It is also recommended that all parties be committed to excellence in support of the new model implementation in Tidar University or elsewhere.