Miracle-dz/UniFAR-FTUs huggingface dataset:
Secure pattern based aggregation using query processing algorithm in wireless sensor networks

Data aggregation is the technique used togather the sensor data to reduce the duplicate data transmission. It is an effectual approach for Wireless Sensor Networks (WSNs) to save energy and prolong network life time. Existing Reliable Spatial Window Aggregation (RESA) query processing algorithm proposed to reduce packet loss rate during data communication and balance the load of nodes. The main problem in existing system is the single node act as the cluster head at every transmission so it takes more energy than the sensor nodes and the duplicate data can be stored at the cluster head. In order to address this problem, a Pattern Based Aggregation using query processing algorithm called PBA is proposed. PBA only requires each node to maintain location of its neighbours. According to the information it divides the query area into several sub regions followed by collection of sensor readings in each sub region. It is proposed to reduce the transmission of duplicate data during communication. An Oscilloscope measurement technique is proposed to measure the energy level of the sensor node.
Comparison of polymeric samplers for accurately assessing PCBs in pore waters

Assessing the hazard posed by sediments contaminated with hydrophobic organic compounds is difficult, because measuring the freely dissolved porewater concentrations of such low‐solubility chemicals can be challenging, and estimating their sediment–water partition coefficients remains quite uncertain. We suggest that more accurate site assessments can be achieved by employing sampling devices in which polymers, with known polymer–water partition coefficients, are used to absorb the contaminants from the sediment. To demonstrate the current accuracy and limitations of this approach, we compared use of three polymers, polydimethylsiloxane, polyoxymethylene, and polyethylene, exposed to a single sediment in two modes, one in which they were exhaustively mixed (tumbled) with the sediment and the other in which they were simply inserted into a static bed (passive). Comparing porewater concentrations of specific polychlorinated biphenyl (PCB) congeners with results obtained using air bridges, we found the results for tumbled polymers agreed within 20%, and the passive sampling agreed within a factor of 2. In contrast, porewater estimates based on sediment concentrations normalized to fOCKOC, the weight fraction of organic carbon times the organic–carbon normalized partition coefficient, averaged a factor of 7 too high. We also found good correlations of each polymer's uptake of the PCBs with bioaccumulation by the polychaete, Neanthes arenaceodentata. Future improvements of the passive sampling mode will require devices that equilibrate faster and/or have some means such as performance reference compounds to estimate mass transfer limitations for individual deployments. Environ. Toxicol. Chem. 2011; 30:1288–1296. © 2011 SETAC
Stage 4S neuroblastoma tumors show a characteristic DNA methylation portrait

ABSTRACT Stage 4S neuroblastoma (NB) is a special type of NB found in infants with metastases at diagnosis and is associated with an excellent outcome due to its remarkable capacity to undergo spontaneous regression. As genomics have not been able to explain this intriguing clinical presentation, we here aimed at profiling the DNA methylome of stage 4S NB to better understand this phenomenon. To this purpose, differential methylation analyses between International Neuroblastoma Staging System (INSS) stage 4S, stage 4 and stage 1/2 were performed, using methyl-CpG-binding domain (MBD) sequencing data of 14 stage 4S, 14 stage 4, and 13 stage 1/2 primary NB tumors (all MYCN non-amplified in order not to confound results). Stage 4S-specific hyper- and hypomethylated promoters were determined and further characterized for genomic localization and function by cytogenetic band enrichment, gene set enrichment, transcription factor target enrichment and differential RNA expression analyses. We show that specific chromosomal locations are enriched for stage 4S differentially methylated promoters and that stage 4S tumors show characteristic hypermethylation of specific subtelomeric promoters. Furthermore, genes involved in important oncogenic pathways, in neural crest development and differentiation, and in epigenetic processes are differentially methylated and expressed in stage 4S tumors. Based on these findings, we describe new biological mechanisms possibly contributing to the stage 4S-specific tumor biology and spontaneous regression. In conclusion, this study is the first to describe the highly characteristic stage 4S DNA methylome. These findings will open new avenues to further unravel the NB pathology in general and stage 4S disease specifically.
Demonstration of $L_{g} \sim \hbox{55}\ \hbox{nm}$ pMOSFETs With $\hbox{Si/Si}_{0.25}\hbox{Ge}_{0.75}/\hbox{Si}$ Channels, High $I_{\rm on}/I_{\rm off}\ (≫ \hbox{5} \times \hbox{10}^{4})$ , and Controlled Short Channel Effects (SCEs)

High-performance sub-60 nm Si/SiGe (Ge:~75%)/Si heterostructure quantum well pMOSFETs with a conventional MOSFET process flow, including gate-first high-kappa/metal gate stacks with ~1 nm equivalent oxide thickness, are demonstrated. For the first time, short gate length (<i>L</i> <sub>g</sub>) devices demonstrate not only controlled short channel effects, but also an excellent on-off current (<i>I</i> <sub>on</sub>/<i>I</i> <sub>off</sub>) ratio (~5times10<sup>4</sup> 55-nm <i>L</i> <sub>g</sub>). The intrinsic gate delay of these heterostructures is ~3 ps at <i>I</i> <sub>on</sub>/<i>I</i> <sub>off</sub>~10<sup>4</sup>. OFF-state leakage was minimized by controlling the defects in the epitaxial films. Finally, these short <i>L</i> <sub>g</sub> devices, when benchmarked against state-of-the-art Si channel pMOSFETs, appear to be very promising in replacing the Si channel in CMOS scaling.
Improving DNA Vaccine Potency by Linking Marek's Disease Virus Type 1 VP22 to an Antigen

ABSTRACT We have previously employed an intercellular spreading strategy using herpes simplex virus type 1 (HSV-1) VP22 protein to enhance DNA vaccine potency because DNA vaccines lack the intrinsic ability to amplify in cells. Recently, studies have demonstrated that the protein encoded by UL49 of Marek's disease virus type 1 (MDV-1) exhibits some degree of homology to the HSV-1 VP22 protein and features the property of intercellular transport. We therefore generated a DNA vaccine encoding MDV-1 VP22 linked to a model antigen, human papillomavirus type 16 E7. We demonstrated that compared with mice vaccinated with DNA encoding wild-type E7, mice vaccinated with MDV-1 VP22/E7 DNA exhibited a significant increase in number of gamma-interferon-secreting, E7-specific CD8+-T-cell precursors as well as stronger tumor prevention and treatment effects. Furthermore, our data indicated that the antitumor effect was CD8 dependent. These results suggested that the development of vaccines encoding VP22 fused to a target antigen might be a promising strategy for improving DNA vaccine potency.
Service-Oriented Business Performance Management for Real-Time Enterprise

This paper presents a SOMA based methodology of defining SOA for business performance management. This method is coined as BPM SOMA. We describe the essential capabilities that are supported by business performance management systems and how these capabilities can be materialized into BPM services that would constitute an SOA for business performance management (BPM). Business integration generates many technologies in last couple of decades, e.g., application integration, middleware, business process modeling and integration, business intelligence and business service management. To a larger extent, BPM contains part of all of the technologies for business integration. Customers are facing more severe business integration challenges than ever. For example, the gap between business and IT is becoming greater. Simple solution of exposing data to customers on the glass is not sufficient to help customers operate their businesses. BPM is aimed for resolving business integration issues by providing an integrated framework, enabling an organization to understand the status of business processes across business and IT, placing that understanding in context against goals and trends and taking timely action to improve business operations
Warp as a machine for low-level vision

Warp is a programmable systolic array processor. One of its objectives is to support computer vision research. This paper shows how the Warp architecture can be used to fulfill the computational needs of low-level vision. We study the characteristics of low-level vision algorithms and show how they lead to requirements for computer architecture. These requirements are met by Warp. We then describe how the Warp system can be used. Warp programs can be classified in two ways: chained versus severed, and heterogeneous versus homogeneous. Chained and severed characterize the degree of interprocessor dependency, while heterogeneous and homogeneous characterize the degree of similarity between programs on individual processors. Taken in combination, these classes give four user models. Sophisticated programming tools are needed to support these user models.
Zidovudine, didanosine, or both as the initial treatment for symptomatic HIV-infected children. AIDS Clinical Trials Group (ACTG) Study 152 Team.

BACKGROUND Zidovudine has been the drug of choice for the initial treatment of symptomatic children infected with the human immunodeficiency virus (HIV). This trial was designed to assess the efficacy and safety of treatment with zidovudine alone as compared with either didanosine alone or combination therapy with zidovudine plus didanosine. METHODS In this multicenter, double-blind study, symptomatic HIV-infected children 3 months through 18 years of age were stratified according to age (<30 months or > or =30 months) and randomly assigned to receive zidovudine, didanosine, or zidovudine plus didanosine. The primary end point was length of time to death or to progression of HIV disease. RESULTS Of the 831 children who could be evaluated, 92 percent had never received antiretroviral therapy and 90 percent had acquired HIV perinatally. An interim analysis (median follow-up, 23 months) showed a significantly higher risk of HIV-disease progression or death in patients receiving zidovudine alone than in those receiving combination therapy (relative risk, 0.61; 95 percent confidence interval, 0.42 to 0.88; P=0.007). The study arm with zidovudine alone was stopped and unblinded; the other two treatment arms were continued. At the end of the study, didanosine alone had an efficacy similar to that of zidovudine plus didanosine (median follow-up, 32 months) (relative risk of disease progression or death, 0.98; 95 percent confidence interval, 0.70 to 1.37; P=0.91). A significantly lower risk of anemia or neutropenia was seen in patients receiving didanosine alone (P=0.036). CONCLUSIONS In symptomatic HIV-infected children, treatment with either didanosine alone or zidovudine plus didanosine was more effective than treatment with zidovudine alone. The efficacy of didanosine alone was similar to that of the combination therapy and was associated with less hematologic toxicity.
Association between morningness and resilience in Korean college students

ABSTRACT Circadian typology and sleep quality may be essential factors associated with the promotion of resilience. However, previous studies investigating the association between circadian typology and resilience did not analyze the effects of sleep quality on resilience. Thus, the present study evaluated the association between circadian typology and resilience in Korean college students after controlling for sleep quality. Additionally, this study investigated several sleep-related variables, including sleep duration, social jetlag and sunlight exposure during the daytime, to examine the modifiable behavioral features of morningness and also investigated whether the findings regarding morningness-related modifiable habits were associated with resilience. This study included 1094 participants (947 males and 147 females) between 19 and 29 years of age (22.8 ± 1.9 years) who completed the 10-item Korean version of the Connor–Davidson Resilience Scale (CD-RISC-10), the Korean version of the Morningness–Eveningness Questionnaire (MEQ), the Pittsburgh Sleep Quality Index (PSQI), the Korean version of the Hospital Anxiety and Depression Scale (HADS) and a survey about social jetlag that determined misalignments between weekday and weekend times of awakening and activity duration under conditions of sunlight between 10:00 and 15:00. A multiple linear regression analysis revealed that sleep duration, mean daily sunlight exposure between 10:00 and 15:00 and age were positive predictors of morningness, whereas social jetlag was a negative predictor of morningness. Of these morningness-related modifiable behavioral features, mean daily sunlight exposure between 10:00 and 15:00 significantly predicted greater resilience. An additional multiple linear regression analysis revealed that morningness was a positive predictor of resilience after controlling for age, sex, depression, anxiety and sleep quality. These results support the idea that morningness and better sleep quality are associated with greater resilience. Morningness was also associated with longer sleep duration, longer sunlight exposure during the daytime and less social jetlag, whereas longer daily sunlight exposure between 10:00 and 15:00 was associated with greater resilience. Future longitudinal studies are needed to examine whether manipulations of morningness-related modifiable behavioral features can rearrange chronotype and promote resilience.
Choosing or losing health?

Constructing a conceptual diagram is as much art as science Conceptual diagrams, models, and frameworks are often used in public health literature to help illustrate relations between health exposures and outcomes. However, it is not always clear what these conceptual tools are describing, what they mean or how best to use, design or present them. In fact, the gaze of even the most critical reader tends to glaze over when suddenly faced with a conceptual diagram that is barely, if at all introduced, let alone explained in the accompanying text. The online Oxford English Dictionary defines a diagram as a “set of lines, marks, or tracings which represent symbolically the course or results of any action or process” or a “delineation used to symbolize related abstract propositions or mental processes”. Adapted from what Earp and Ennett1 call a “conceptual model”, we define a conceptual diagram as a “diagram of proposed relationships among a set of concepts, factors, or variables about a particular hypothesis, question, context, problem or topic”. Conceptual diagrams are used to organise and synthesise knowledge, define concepts, provide explanations for causal and associative linkages, generate hypotheses …
Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

The p53-inducible protein TIGAR (Tp53-induced Glycolysis and Apoptosis Regulator) functions as a fructose-2,6-bisphosphatase (Fru-2,6-BPase), and through promotion of the pentose phosphate pathway, increases NADPH production to help limit reactive oxygen species (ROS). Here, we show that under hypoxia, a fraction of TIGAR protein relocalized to mitochondria and formed a complex with hexokinase 2 (HK2), resulting in an increase in HK2 activity. Mitochondrial localization of TIGAR depended on mitochondrial HK2 and hypoxia-inducible factor 1 (HIF1α) activity. The ability of TIGAR to function as a Fru-2,6-BPase was independent of HK2 binding and mitochondrial localization, although both of these activities can contribute to the full activity of TIGAR in limiting mitochondrial ROS levels and protecting from cell death.
Effects of Chronic Exercise on Blood Volume Expansion and Hematologic Indices During Pregnancy

Objective: To evaluate the value of selective laparotomy in pregnant women with penetrating abdominal injuries. Methods: A retrospective survey was carried out at our center over 16 years of civil war, extending from 1975 to 1991. Fourteen pregnant women had uterine injuries secondary to high-velocity abdominal penetrating trauma. The corresponding management was evaluated carefully with respect to maternal and fetal outcomes. Results: Two maternal deaths occurred, neither resulting solely from intra-abdominal injuries. Visceral injuries were present when the entrance of the missile was in either the upper abdomen or the back. When the entry site was anterior and below the uterine fundus, visceral injuries were absent in all six women upon surgical exploration. Perinatal deaths occurred in half of the cases and were due to maternal shock or uteroplacental or direct fetal injury. Immediate cesarean delivery was performed because of either limited surgical field exposure, fetal injury, or distress. Three patients explored were managed by delaying delivery. All later delivered vaginally with successful fetal outcomes in all three. Conclusion: Selective laparotomy may be considered in pregnant women with anterior penetrating abdominal trauma, as the likelihood of intra-abdominal injuries may be predicted based on the location of the penetrating wound. (Obstet Gynecol 1994;83:259-64)
Airborne behaviour monitoring using Gaussian processes with map information

This study proposes an airborne behaviour monitoring methodology of ground vehicles based on a statistical learning approach with domain knowledge given by road map information. To monitor and track the moving ground target using unmanned aerial vehicle aboard a moving target indicator, an interactive multiple model (IMM) filter is firstly applied. The IMM filter consists of an on-road moving mode using a road-constrained filter and an off-road moving mode using a conventional filter. Mode probability is also calculated from the IMM filter, and it provides deviation of the vehicle from the road. Then, a novel hybrid algorithm for anomalous behaviour recognition is developed using a Gaussian process regression on velocity profile along the one-dimensionalised position of the vehicle, as well as the deviation of the vehicle. To verify the feasibility and benefits of the proposed approach, a numerical simulation is performed using realistic car trajectory data in a city traffic.
The use of mirids and anthocorid bugs as polyphagous predators in greenhouse crops

Polyphagous predators have shown to be a viable solution for IPM programs in vegetable crops. In this paper advantages and disadvantages of using polyphagous predators are discussed. We also summarize existing experiences on the use of refuge plants to implement conservation programs. Recent experiences conducted by our group for the conservation of mirid and anthocorid bugs in tomato and lettuce Mediterranean crops are explained. The presence of refuge plants in the crop margins can increase the abundance of those polyphagous predators, advance their presence in the crop and facilitate their establishment, contributing to control crop pests, besides to be also beneficial to other neighbouring vegetable crops.
Long-Term Effects of Growth Hormone Therapy on Bone Mineral Density, Body Composition, and Serum Lipid Levels in Growth Hormone Deficient Children: A 6-Year Follow-Up Study

Aim: To study the effects of growth hormone (GH) deficiency (GHD) and GH replacement therapy (GHRx) on bone mineral density (BMD) and body composition. Methods: 59 GHD children participated (age range 0.4–16.9 years); the follow-up period was 6 years. Lumbar spine BMD (BMD<sub>LS</sub>), total-body BMD (BMD<sub>TB</sub>), and body composition were measured prospectively using dual-energy X-ray absorptiometry. Results: Mean BMD<sub>LS </sub>and BMD<sub>TB</sub> were significantly reduced at the time of the diagnosis. The bone mineral apparent density of the lumbar spine (BMAD<sub>LS</sub>) was reduced to a lesser degree. The BMAD<sub>LS</sub> increased to normal values after 1 year; BMD<sub>LS</sub> and BMD<sub>TB</sub> normalized 1 year later. At the time of the diagnosis, the lean body mass was reduced and steadily increased during GHRx. Percentage of body fat was increased at baseline and normalized within 6 months. The severity of GHD was not associated with the BMD at diagnosis or the response to GHRx. Conclusion: Areal BMD<sub>LS</sub> and BMD<sub>TB</sub> and, to a lesser extent, BMAD<sub>LS</sub> are decreased in GHD children, but normalize within 1–2 years.
Antimicrobial activity of Marcetia DC species (Melastomataceae) and analysis of its flavonoids by reverse phase-high performance liquid chromatography coupled-diode array detector

Background: Marcetia genera currently comprises 29 species, with approximately 90% inhabiting Bahia (Brazil), and most are endemic to the highlands of the Chapada Diamantina (Bahia). Among the species, only M. taxifolia (A.St.-Hil.) DC. populates Brazil (state of Roraima to Paraná) and also Venezuela, Colombia, and Guyana. Objective: This work evaluated the antimicrobial activity of hexane, ethyl acetate, and methanol extracts of three species of Marcetia (Marcetia canescens Naud., M. macrophylla Wurdack, and M. taxifolia A.StHil) against several microorganism. In addition, the flavonoids were analyzed in extracts by HPLC-DAD. Materials and methods: The tests were made using Gram-positive (three strains of Staphylococcus aureus) and Gram-negative (two strains of Escherichia coli, a strain of Pseudomonas aeruginosa and another of Salmonella choleraesius) bacteria resistant and nonresistant to antibiotics and yeasts (two strains of Candida albicans and one of C. parapsilosis) by the disk diffusion method. Solid-phase extraction (SPE) was performed on the above extracts to isolate flavonoids, which were subsequently analyzed by high performance liquid chromatography coupled diode array detector (HPLC-DAD). Results: Results showed that extracts inhibited the Gram-positive bacteria and yeast. The hexane extracts possessed the lowest activity, while the ethyl acetate and methanolic extracts were more active. Conclusion: Marcetia taxifolia was more effective (active against 10 microorganisms studied), and only its methanol extract inhibited Gram-negative bacteria (P. aeruginosa and S. choleraesius). SPE and HPLC-DAD analysis showed that M. canescens and M. macrophylla contain glycosylated flavonoids, while the majority of extracts from M. taxifolia were aglycone flavonoids.