Miracle-dz/UniFAR-FTUs huggingface dataset:
High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission.

BACKGROUND We sought to determine the diagnostic performance of the new high-sensitivity cardiac troponin T (hs-cTnT) assay for early detection of non-ST-segment myocardial infarction (NSTEMI) in patients with acute coronary syndrome. METHODS We enrolled patients with retrospectively confirmed unstable angina or NSTEMI and an initially negative cTnT concentration and compared the performance of baseline concentrations and serial changes in concentration within 3 and 6 h. Percentage change criteria included >or=20% delta change and ROC-optimized value. RESULTS Based on the standard fourth-generation cTnT result of >or=0.03 microg/L, an evolving NSTEMI was diagnosed in 26 patients, and 31 patients were classified as having unstable angina. With the use of the hs-cTnT assay at the 99th-percentile cutoff, the percentage of NSTEMI cases detected increased gradually from 61.5% on presentation to 100% within 6 h, and the overall number of MI diagnoses increased by 34.6% (35 vs 26 cases). A delta change >or=20% or >or=ROC-optimized value of >117% within 3 h or >or=243% within 6 h yielded a specificity of 100% at sensitivities between 69% and 76%. The standard cTnT at the 99th percentile was less sensitive than hs-cTnT for early diagnosis of MI on presentation, and follow-up samples obtained within the initial 3 h demonstrated very low specificity of cTnT compared with hs-cTnT. CONCLUSIONS The high-sensitivity cTnT assay increases the number of NSTEMI diagnoses and enables earlier detection of evolving NSTEMI. A doubling of the hs-cTnT concentration within 3 h in the presence of a second concentration >or=99th percentile is associated with a positive predictive value of 100% and a negative predictive value of 88%.
Temperature dependence of band gaps in semiconductors: Electron-phonon interaction

We have theoretically investigated, by ab initio techniques, the phonon properties of several semiconductors with chalcopyrite structure. Comparison with experiments has led us to distinguish between materials with d electrons in the valence band (e.g., CuGaS2, AgGaS2) and those without d electrons (e.g., ZnSnAs2). The former exhibit a rather peculiar nonmonotonic temperature dependence of the energy gap which, so far, has resisted cogent theoretical description. We analyze this nonmonotonic temperature dependence by fitting two Bose-Einstein oscillators with weights of opposite sign leading to an increase at low temperatures and a decrease at higher temperatures and find that the energy of the former correlates well with characteristic peaks in the phonon density of states associated with low-energy vibrations of the d-electron elements. We hope that this work will encourage theoretical investigations of the electron-phonon interaction in this direction, especially of the current ab initio type.
Research on Risk Factors Identification of P2P Lending Platforms

We take 2259 P2P Lending platforms as the sample, and integrate 14 variables from five dimensions to analyze the risk factors of P2P Lending problematic platforms by binary logistic model. The empirical results show that the 11 variables which are the type of company, platform background, operation time, the type of project, interest rate, fund custody, term of loan, day-bid, transfer of creditor’s rights, automatic bidding and information disclosure, have significant influences on the operating status of the platform, while the other variables such as registered capital, the number of employees and security mechanism have no obvious impact on the operating status of the platform. The results provide a reference for investors and regulators.
Etude de l'effet antitumoral de l'activation de la NO-synthase inductible dans un modèle de cancer du sein : analyse des mécanismes moléculaires

L’effet anti-tumoral d'un lipide A, l’OM-174 (partie lipidique des lipopolysaccharides) a ete etudie dans un modele de cancer mammaire chez la souris. In vivo, l’OM-174 augmente la survie de la souris alors qu’in vitro il n'est pas toxique pour les cellules cancereuses. L’OM-174 se lie au recepteur TLR4 des cellules immunitaires induisant la production de cytokines comme l’IFNγ. In vitro, l’association de cette cytokine au lipide A est cytotoxique. L’objectif de cette these est d’en analyser les mecanismes moleculaires. Nous avons montre, aussi bien in vitro qu’in vivo, que la cytotoxicite du lipide A/IFNγ est dependante du TLR4, du recepteur a l’IFNγ et de l’expression de la NOS II. Nous avons egalement montre que les especes radicalaires, NO et anion superoxyde formant le peroxynitrite jouent un role crucial dans cette cytotoxicite. L’origine de ces especes radicalaires se trouve etre la NOS II selon un processus de decouplage enzymatique. Nous avons egalement cherche d’autres mecanismes associes pouvant expliquer la cytotoxicite du lipide A/IFNγ. Nous avons ensuite montre que le NO est capable de reagir avec les residus cysteine de certaines proteines, un processus appele S-nitrosylation. Une analyse proteomique nous a permis d’identifier au moins une dizaine de proteines qui sont S-nitrosylees dans les cellules cancereuses mammaires en reponse au lipide A/IFNγ. Nous avons etudie l’impact de cette modification sur la fonction d’une des ces proteines, l’enzyme de conjugaison E2 de l’ubiquitine Ubc13, une proteine impliquee dans la proliferation et la survie cellulaire. Nous avons confirme la nitrosylation d’Ubc13 et identifie la cysteine 87 comme cible du NO. L’expression d’une forme mutee d’Ubc13 (remplacement de la cysteine 87 par une alanine) inhibe l’auto-ubiquitination de l’enzyme et sa capacite a ubiquitiner une de ses cibles IkBα. Nous avons montre que la S-nitrosylation d’Ubc13 induit sa migration vers le noyau et rend les cellules plus sensibles a l’effet cytotoxique du lipide A/IFNγ. En resume, nos resultats revelent un role majeur et insoupconne de la NOS II et du NO dans l’effet antitumoral du lipide A OM-174 dans un modele de cancer mammaire chez la souris ouvrant la voie pour la conception de nouveaux traitements anticancereux.
Cost management for PLM systems: A way to improve the competitiveness in digital economy

Two of the most efficient ways of increasing digital economy systems’ competitiveness are creating digital twins using PLM-based cost management instruments. Determining machinery’s cost characteristics on the conceive step of their lifecycle is the most efficient if it’s based on probabilistic approach. On the next steps of design process, such as concept design and detailed design, a designed construction’s price should be estimated basing on its informational (parametric) complexity indexes. This price is to be compared with earlier estimated approximate parameters. The most efficient way of using presented approach is making it a part of CAx system (first of all, such systems as MCAD and EDA). It may be applied as a part of invariant subsystem of technical and economic parameters for the computer-aided account facilities and for simulation of processes (CAE, CAA). The most appropriate way of organizing design and development processes is to use AGILE ideology. This approach gives a possibility to create an integral system of creating digital twins that is useable on any step of product’s lifecycle.
Limited vitrectomy in phacomorphic glaucoma

One of the challenging situations for a cataract surgeon is phacoemulsification in the shallow anterior chamber like cases of phacomorphic glaucoma. Some of the main concerns of operating in a narrow space include endothelial decompensation, descemet's detachment, and posterior capsular rents. High vitreous pressure predisposes to posterior capsular rents owing to a reduced concavity of the posterior capsule and increasing the proximity of phaco-tip to the posterior capsule. We describe a technique of limited vitrectomy in such cases. A small gauge 23-G/25-G trocar cannula is passed transconjunctivally, and the liquefied vitreous is allowed to egress. Vitrectomy is done extraocularly till the vitreous pressure lowers down. This technique helps to debulk the vitreous and decompress the globe in a controlled manner. The resultant posterior displacement of iris-lens diaphragm causes a deepening of the anterior chamber to facilitate phacoemulsification.
Architecture exploration for distributed embedded systems: a gap analysis in automotive domain

A large body of work can be found in literature on Design Space Exploration (DSE) methods for distributed embedded system architecting (DESA). However, almost none of these methods is successfully adopted in automotive industry. To clarify the reasons, this paper 1) analyzes the current state of the art (SOTA) on DSE methods for DESA through a systematic literature study, focusing on the assumed architecting process and concerns; 2) investigates the state of practice (SOP) on DESA in the automotive industry through a literature study and interviews with experienced system architects from five different automotive manufacturers; and 3) analyzes the gap between SOTA and SOP, and thereby discusses potential improvements of DSE methods.
The YvqE two‐component system controls biofilm formation and acid production in Streptococcus pyogenes

In Streptococcus pyogenes, proteins involved in determining virulence are controlled by stand‐alone response regulators and by two‐component regulatory systems. Previous studies reported that, compared to the parental strain, the yvqE sensor knockout strain showed significantly reduced growth and lower virulence. To determine the function of YvqE, we performed biofilm analysis and pH assays on yvqE mutants, and site‐directed mutagenesis of YvqE. The yvqE deletion mutant showed a slower acid production rate, indicating that YvqE regulates acid production from sugar fermentation. The mutant strain, in which the Asp26 residue in YvqE was replaced with Asn, affected biofilm formation, suggesting that this amino acid senses hydrogen ions produced by fermentative sugar metabolism. Signals received by YvqE were directly or indirectly responsible for inducing pilus expression. This study shows that at low environmental pH, biofilm formation in S. pyogenes is mediated by YvqE and suggests that regulation of pilus expression by environmental acidification could be directly under the control of YvqE.
Applying Structural Matching and Paraphrasing

We discuss the potentialities of structural matching as a compromise between fully-conceptual deep processing approaches and shallow bag-of-words approaches to answer seeking. We extended Collins’s Tree Kernel [1] to formulate a new algorithm for soft structural matching, and we also developed and tested a method for combing structural matching with paraphrasing. Unfortunately, we found no positive empirical evidence that either structural matching or paraphrasing contribute to question answering. We believe, however, that their usefulness should not be ruled out yet. We still need more deliberate experiments and analysis.
Gesture recognition based on improved shape context algorithm and Earth Mover's Distance

The common shape context algorithm does not have the rotational invariance property, which makes the characteristic extraction accuracy decreased a lot under some circumstances. A new improved shape context algorithm is proposed to solve this problem in this paper. The new algorithm chooses some key points and uses them as reference points, rather than like the traditional way that relies on all the contour information. Such improvement can make the new shape context algorithm rotation-invariant and can also simplify the original algorithm. Besides, another improvement is made in this paper. We combine shape context algorithm with EMD to create a new recognition method. The method is used for gesture recognition, and the experiment result shows that the new method has enhanced the gesture recognition accuracy a lot.
On-line real-time digital computer separation of extracellular neuroelectric signals.

An on-line real-time spike recognition and separation system for up to six different spikes in multiple unit extracellular records has been developed using the Micro-LINC 300 computer. Assuming biphasic potentials, the computer extracts four unambiguous variables, two in amplitude and two in time. One variable of a selected pair is plotted against the other on the computer CRT. Points representing the same class of signal will fall into clusters. Cluster boundaries for spike separation are set visually by the investigator. Output is in the form of pulses on different relay lines. The system permits waveforms to overlap up to 15 percent. Examples of system performance with real signals are presented. A comparison is made with other spike recognition systems. A simple system is presented for generating artificial test signals and a technique described for testing any spike recognition system.
Introduction of Different Lineages of Aedes aegypti In Argentina

Abstract Based on sequence analysis of the mitochondrial gene ND4, we determined the presence in Argentina of 3 haplotypes representing different Aedes (Stegomyia) aegypti lineages previously identified in other countries of the Americas, Africa, and Asia. Haplotype 17, the most frequent in Argentina, was previously detected in Brazil. Haplotype 7, restricted in our study to the northwest of Argentina and Bolivia, was formerly found in low frequency in the USA, Brazil, Mexico, and Senegal. Also haplotype 11, belonging to a different haplogroup than the other two, was observed in the present study; it had been reported before in Africa and Asia, but not in the Americas. The coexistence of haplotypes belonging to divergent haplogroups supports the hypothesis of multiple introductions of the species in Argentina.
Comparison of 3 phytases on energy utilization of a nutritionally marginal wheat-soybean meal broiler diet.

The net energy (NE) value may be a better measure than apparent metabolizable energy (ME) of the effect of supplemental phytase on energy utilization in broilers. The present study was conducted to assess the impact of 3 microbial phytases supplemented at an unconventionally high level (1,000 FTU/kg feed) on performance and NE of broilers using the indirect calorimetric method (IC). Four treatments included: 1) Control, formulated to be deficient in ME (12.35 MJ/kg in the starter diet; 12.56 MJ/kg in the grower diet), calcium (0.72% in the starter diet; 0.60% in the grower diet), and available phosphorus (0.25% in the starter diet; 0.20% in the grower diet); 2) control + intrinsically thermostable phytase A; 3) control + intrinsically thermostable phytase B; and 4) control + coated phytase C. A completely randomized design was employed. A total of 384 male broiler chicks were used, and each treatment had 6 replicates with 16 birds per replicate. The birds were reared until d 21 in floor pens with hardwood shavings. Thirty-two birds (8 birds per treatment) were randomly selected to determine heat production and NE (from 25-28 d) following a 3-d acclimatization in the respiratory chambers. Performance results at d 21 showed that supplementation with either of the 3 phytases improved body weight (P < 0.001) and feed intake (P < 0.05), and increased the relative weights of tibia ash (P < 0.05) and toe ash (P < 0.01). Phytases A and B increased the NE value of the diet (P < 0.05). It may be concluded that the negative effects imposed by calcium and available phosphorus down-specification can be compensated by phytase supplementation in general, and intrinsically thermostable phytases improve the ME and NE value. However, phytase did not reduce heat production, heat increment, or increase NE:ME in birds.
Contribution à l'étude de la sémantique de l'espace et du temps : analyse des verbes de déplacement transitifs directs du français

Parler de classe de "verbes de deplacement" laisse supposer qu'il s'agit d'une classe homogene rassemblant des verbes presentant un ensemble de proprietes communes, et se distinguant clairement d'autres verbes, non spatiaux. Notre etude des verbes entrant dans la construction transitive directe [SN Leon V traverse SN la rue] (cf. Table 38L1 du LADL : monter, traverser, heurter, atteindre etc. ) a cependant revele une profonde heterogeneite de la classe. Mais, au dela de son aspect descriptif et classificatoire, cette these propose une re����flexion sur l'articulation entre transitivite syntaxique et transitivite semantique. D'un point de vue cognitif, il est paradoxal d'exprimer du mouvement (phenomene parfaitement continu) dans une construction transitive directe qui exprime prototypiquement une action telique ou un sujet agent affecte un objet patient. Mais ce paradoxe disparait si l'on fait l'hypothese que la relation de localisation n'est pas directement determinee par rapport a l'objet. Cette these soutient, en se fondant a la fois sur la definition d'une ontologie des entites spatiales, ainsi que sur la theorie des forces dynamiques de Talmy et sur la theorie multifactorielle de la transitivite de Hopper & Thompson, que l'attribution, a l'objet direct, des roles semantiques concurrents (patient vs site) repose sur le caractere plus ou moins direct du rapport v0. Schematiquement, on a etabli une classification des verbes reposant sur un continuum defini entre les verbes proprement locatifs qui expriment intrinsequement un proces dynamique, et les verbes d'action qui expriment une action induisant accessoirement un deplacement. La these presente les criteres qui ont permis d'etablir une typologie de ces verbes, en insistant tout particulierement sur les rapports etroits existant entre le mode d'ancrage referentiel d'une relation de localisation par rapport a une entite, la nature ontologique de cette entite, l'aspect du verbe et son degre de transitivite semantique
icmT Is Essential for Pore Formation-Mediated Egress of Legionella pneumophila from Mammalian and Protozoan Cells

ABSTRACT The final step of the intracellular life cycle of Legionella pneumophila and other intracellular pathogens is their egress from the host cell after termination of intracellular replication. We have previously isolated five spontaneous mutants of L. pneumophila that replicate intracellularly similar to the wild-type strain but are defective in pore formation-mediated cytolysis and egress from mammalian and protozoan cells, and the mutants have been designated rib (release of intracellular bacteria). Here, we show that the rib mutants are not defective in the activity of enzymes secreted through the type II secretion system, including phospholipase A, lysophospholipase A, and monoacylglycerol lipase, although they are potential candidates for factors that lyse host cell membranes. In addition, the pilD and lspG mutants, which are defective in the type II secretion system, are not defective in the pore-forming toxin. We show that all five rib mutants have an identical point mutation (deletion) following a stretch of poly(T) in the icmT gene. Spontaneous revertants of the rib mutants, due to an insertion of a nucleotide following the poly(T) stretch in icmT, have been isolated and shown to have regained the wild-type phenotype. We constructed an icmT insertion mutant (AA100kmT) in the chromosome of the wild-type strain by allelic exchange. The AA100kmT mutant was as defective as the rib mutant in pore formation-mediated cytolysis and egress from mammalian and protozoan cells. Both the rib mutant and the AA100kmT mutant were complemented by the icmT gene for their phenotypic defect. rtxA, a gene that is thought to have a minor role in pore formation, was not involved in pore formation-mediated cytolysis and egress from mammalian and protozoan cells. We conclude that the icmT gene is essential for pore formation-mediated lysis of mammalian and protozoan cells and the subsequent bacterial egress.
4218T/C polymorphism associations with post‐cesarean patient‐controlled epidural fentanyl consumption and pain perception

The utilization of intrathecal opioids is an efficacious component of post‐cesarean section pain management. Given that growing evidence indicates that calcitonin gene‐related peptide (CGRP) plays a key role in the development of peripheral sensitization and is associated with enhanced pain, we hypothesized that CGRP 4218T/C polymorphism is associated with the variability in fentanyl consumption for post‐cesarean analgesia.
Platforms as entrepreneurial incubators? How online labor markets shape work identity

Purpose The purpose of this paper is to explore how the process of work identity construction unfolds for gig workers experiencing unstable working relationships in online labor markets. In particular, it investigates how digital platforms, intended both as providers of technological features and online environments, affect this process. Design/methodology/approach The authors conducted an exploratory field study and collected data from 46 interviews with freelancers working on one of the most popular online labor markets and from online documents such as public profiles, job applications and archival data. Findings The findings reveal that the online environment constrains the action of workers who are pushed to take advantage of the platform’s technological features to succeed. This interplay leads workers to add new characteristics to their work-self and to and to develop an entrepreneurial an entrepreneurial orientation. Practical implications The study offers insights to platform providers interested in improving workers’ experiences in online labor markets, highlighting mechanisms for uncertainty reduction and diversifying a platform’s services according to gig workers’ identities and orientations. Originality/value The study expands the authors’ knowledge on work identity construction processes of gig workers, detailing the relationship between work identity and IT, and documents previously unexplored antecedents of entrepreneurial orientation in non-standard working contexts.
Sportivate: a case study of sports policy implementation and impact on the sustainability of community physical activity programmes

With trends pointing towards shortcomings in delivering London 2012 legacy promises, a review was administered on research and policy from 2005 onwards to ascertain how sports policy can impact upon the sustainability of delivering funded community sports and physical activity programmes. A case study design was adopted and secondary data was obtained from Sport England’s Year 4 of national Sportivate data. These results were compared with aspects of government policy via the theoretical concept lenses of sustainability and policy implementation. Secondary data from Sport England for Year 4 (2014-15) of their Sportivate programme displays a boom in participation leading up to the Olympic Games but plateaus following London 2012. Completed participants primarily consist of younger children, which resonates with requirements issued by government policy. Whilst findings display a closing gender gap in participation, the same cannot be truly be said sustainability measures in place for the Sportivate programme With the prevalence of external factors impeding sports participation, voluntary sports organisations are advised to capitalise on partnership approach methods for delivering sport and physical activity. With measures of participation retention decreasing in Year 4, the theoretical concept of sustainability offers further calls for a change in culture despite policy implementation perspectives highlighting the synthesis of both top-down and bottom-up approaches. A centralised system creates greater emphasis on the professionalisation of voluntary sports organisations which seems to steer deliverers towards short-term impact rather than long-term goals. Recommendations suggest expanding collaborative measures between organisations to help facilitate sustainable participation after a funded physical activity programme has completed.