Miracle-dz/UniFAR-FTUs huggingface dataset:
Mesure adaptative non destructive du nombre de photons dans une cavité

Une mesure adaptative vise a optimiser l'acquisition d'information sur un systeme a l'aide d'une boucle de retroaction sur l'appareil de mesure. Dans notre dispositif d'electrodynamique en cavite, nous avons realise une mesure adaptative sur un systeme quantique, le champ micro-onde piege dans une cavite supraconductrice de tres grande finesse. Des atomes de Rydberg circulaires, interagissant dispersivement avec le champ, realisent une serie de mesures dites "faibles", aboutissant a la mesure quantique non destructive du nombre de photons dans le mode. La prise en compte des resultats des mesures successives, de l'action en retour sur le systeme, et de l'ensemble des imperfections experimentales, permet a un ordinateur de controle d'effectuer une estimation en temps reel de l'etat du champ. La phase de l'interferometre de Ramsey qui definit la mesure realisee sur les atomes est alors optimisee afin d'extraire un maximum d'information des detections ulterieures. Nous montrons que preparation d'etats de Fock est nettement acceleree avec la methode adaptative, par rapport a un protocole passif utilisant une alternance predefinie des phases de mesure. Cette reduction du temps de mesure est d'un grand interet en presence de decoherence, et pourrait par exemple etre exploitee dans des protocoles de retroaction quantique existants, ou la rapidite de l'estimation d'etat est cruciale.
Tourism Destination Recommender System for the Cold Start Problem

With the advent and popularity of e-commerce, an increasing number of consumers prefer to order tourism products online. A recommender system can help these users contend with information overload; however, such a system is affected by the cold start problem. Online tourism destination searching is a more difficult task than others on account of its more restrictive factors. In this paper, we therefore propose a tourism destination recommender system that employs opinion-mining technology to refine user preferences and item opinion reputations. These elements are then fused into a hybrid collaborative filtering method by combining user- and item-based collaborative filtering approaches. Meanwhile, we embed an artificial interactive module in our recommender system to alleviate the cold start problem. Compared with several well-known cold start recommendation approaches, our method provides improved recommendation accuracy and quality. A series of experimental evaluations using a publicly available dataset demonstrate that the proposed recommender system outperforms existing recommender systems in addressing the cold start problem.
Relaciones morfoléxicas prefijales del español

Resumen: En este trabajo se presenta una taxonomia de los sufijos derivativos y terminaciones usadas en espanol utiles para el establecimiento de relaciones morfolexicas deducidas a partir del un corpus de 134109 formas canonicas. Se desarrolla un sistema capaz de resolver y responder a cualquier aspecto morfologico de una palabra del espanol que abarca todo lo relacionado con la morfologia derivativa y otros aspectos cercanos. Permite el reconocimiento, la generacion y la manipulacion de las relaciones morfolexicas a partir de cualquier palabra, categoria gramatical de la base y de sus palabras relacionadas, incluye la recuperacion de toda su informacion lexicogenetica hasta llegar a una primitiva, la gestion y control de los afijos en el tratamiento de sus relaciones, asi como la regularidad en la relacion establecida. Palabras clave: morfologia, lematizacion, derivacion, sufijacion, linguistica computacional.
The Contaminated High‐Energy Open Fracture: A Protocol to Prevent and Treat Inflammatory Mediator Storm‐Induced Soft‐Tissue Compartment Syndrome (IMSICS)

&NA; The treatment modalities currently used in surgical débridement leave the traumatic wound with viable but tenuous tissue and a variable level of microcontaminants potentially laden with bacteria. In high‐energy contaminated wounds, retention of these contaminants within the tenuous tissue of the so‐called zone of stasis can result in further tissue necrosis and the development of infection. A novel protocol for managing the high‐energy contaminated open fracture involves two new techniques. First, Bernoulli's principle is used to facilitate a systematic excision of contaminants, as well as the wound surface to which they are adsorbed, by means of a high‐velocity fluid stream. Second, topical negative pressure is established as a means to resuscitate the remaining edema‐laden wound tissue to help avoid embarrassment to microcirculatory blood flow.
Identification of neuropeptide-like protein gene families in Caenorhabditis elegans and other species

Neuropeptides play critical roles in synaptic signaling in all nervous systems. Unlike classical neurotransmitters, peptidergic neurotransmitters are encoded as preproproteins that are posttranslationally processed to yield bioactive neuropeptides. To identify novel peptidergic neurotransmitters, the Caenorhabditis elegans genome was searched for predicted proteins with the structural hallmarks of neuropeptide preproproteins. Thirty-two C. elegans neuropeptide-like protein (nlp) genes were identified. The nlp genes define at least 11 families of putative neuropeptides with unique motifs; similar expressed sequence tags were identified in other invertebrate species for all 11 families. Six of these families are defined by putative bioactive motifs (FAFA, GGxYamide, MRxamide, LQFamide, LxDxamide, and GGARAF); the remaining five families are related to allatostatin, myomodulin, buccalin/drosulfakinin, orcokinin, and APGWamide neuropeptides (MGL/Famide, FRPamide, MSFamide, GFxGF, and YGGWamide families, respectively). Most C. elegans nlp gene expression is in neurons. The C. elegans nlp genes and similar genes encoding putative neuropeptides in other species are likely to play diverse roles in nervous system function.
Direct anti-atherosclerotic therapy preventing intracellular cholesterol retention

The key initiating process in atherogenesis is the subendothelial cholesterol retention, which is both necessary and sufficient to provoke lesion initiation. Retention of cholesterol transported by low density lipoprotien (LDL) in subendothelial cells of arterial wall, is an absolute requirement for lesion development. This allows us to consider intracellular cholesterol retention as a novel target for anti-atherosclerotic therapy. In this case, the target is not the level of blood cholesterol but the level of cholesterol in vascular cells. This review summarizes the results of our basic studies shedding light on the mechanisms of intracellular cholesterol retention. We describe our cellular models to search for anti-atherosclerotic agents and demonstrate the use of these models for the development of anti-atherosclerotic drugs. We use natural products as the basis of anti-atherosclerotic drugs because anti-atherosclerotic therapy should be long-term or even lifelong. Using cellular models and natural products, we have developed an approach to prevent intracellular cholesterol retention in cultured subendothelial aortic cells. We have developed drugs that reduce intracellular cholesterol retention, namely Allicor on the basis of garlic powder, anti-inflammatory drug Inflaminat (calendula, elder, and violet) possessing anti-cytokine activity and phytoestrogen-rich drug Karinat (garlic powder, extract of grape seeds, green tea leaves, hop cones, β-carotene, α-tocopherol, and ascorbic acid). Treatment with Allicor or Inflaminat caused regression of carotid atherosclerosis in asymptomatic men. Karinat prevented the development of new atherosclerotic plaques in postmenopausal women. Thus, the main findings of our basic research have been successfully translated into clinics. As a result, this translation, a novel approach to the development of anti-atherosclerotic therapy, has been established. Our clinical trials have confirmed the suitability of innovative approach and the efficacy of novel drugs developed on the basis our methodology.
Dynamic analysis of a two-input Zeta converter topology for modular hybrid PV-wind microgrid system

This paper presents the dynamic modeling of a two-input Zeta converter topology using State-space averaging (SSA) technique. The modeling leads to a small-signal linear dynamic model of the multiple-input converter (MIC), from which the transfer functions used for feedback control design can be determined. To verify the accuracy of the obtained model, a two-input Zeta converter with inputs from PV array and wind turbine generation system (WTGS) is designed which can produce an output voltage of 350 Vdc and an output power of 1kW. A controller for this is designed based from the transfer functions derived from the dynamic analysis conducted. Simulation tests of the design are performed using blocks and component of Matlab/Simulink from its SimPower Systems Toolbox. Results are presented to verify the accuracy of the obtained model.
Fluorescence Microscopy Demonstrates Enhanced Targeting of Telavancin to the Division Septum of Staphylococcus aureus

ABSTRACT The cellular binding patterns of fluorescent conjugates of telavancin and vancomycin were evaluated in Staphylococcus aureus by fluorescence microscopy and ratio imaging analysis. Telavancin showed enhanced binding at the division septum compared to vancomycin. This result is consistent with observations that telavancin binds with higher affinity to lipid II than to d-Ala-d-Ala residues in the cell wall, thus demonstrating the preferential binding of telavancin to the site of active cell wall biosynthesis.
Details of the arrangement of the outer capsid of rice dwarf phytoreovirus, as visualized by two-dimensional crystallography

Two-dimensional crystals were obtained from purified P8, an outer capsid protein of rice dwarf phytoreovirus. A filtered image of the two-dimensional crystal, in combination with the results of biochemical analysis, revealed the unit formation of the capsid protein, a capsomere structure, which appeared to be an approximately equilateral triangle with sides of approximately 6 nm and which was composed of a trimer of P8 protein. Details of the arrangements of the outer capsid of the virus are described.
Formal verification of Time-Triggered Ethernet protocol using PRISM model checker

The Time-Triggered Ethernet (TTE) protocol is becoming widely used in safety-critical environments where failures cannot be tolerated. In this paper, a PRISM model for a TT-Ethernet is proposed based on its specification. A set of TTE properties is proposed as well. Finally, using PRISM model checker, a formal model is proposed in the form of a finite state machine. Using this approach, we were able to identify one faulty state within the network that might cause massive damage to a real-life application, thus revealing a possible weak point in Time-Triggered Ethernet.
In Vivo Cartilage Formation Using Chondrogenic-Differentiated Human Adipose-Derived Mesenchymal Stem Cells Mixed With Fibrin Glue

Human adipose-derived mesenchymal stem cells (MSCs) were differentiated into chondrogenic MSCs, and fibrin glue was used together to explore the feasibility of whether cartilages can be generated in vivo by injecting the differentiated cells. Mesenchymal stem cells extracted from human adipose were differentiated into chondrogenic MSCs, and such differentiated cells mixed with fibrin glue were injected subcutaneously into the back of the nude mouse. In addition to visual evaluation of the tissues formed after 4, 8, and 12 weeks, hematoxylin-eosin staining, Masson trichrome staining, measurement of glycosaminoglycan concentration using dimethylmethylene blue, agreecan through reverse transcriptase-polymerase chain reaction, type II collagen, and expression of SOX-9 were verified. Moreover, the results were compared with 2 groups of controls: 1 control group that received only injection of chondrogenic-differentiated MSC and the supporting control group that received only fibrin glue injection. For the experimental group, cartilage-like tissues were formed after 4, 8, and 12 weeks. Formation of cartilage tissues was not observed in any of 4, 8, and 12 weeks of the control group. The supporting control group had only a small structure formation after 4 weeks, but the formed structure was completely decomposed by the 8th and 12th weeks. The range of staining dramatically increased with time at 4, 8, and 12 weeks in Masson trichrome staining. The concentration of glycosaminoglycan also increased with time. The increased level was statistically significant with more than 3 times more after 8 weeks compared with 4 weeks and more than 2 times more after 12 weeks compared with 8 weeks. Also, in reverse transcriptase-polymerase chain reaction at 4, 8, and 12 weeks, all results expressed a cartilage-specific gene called aggrecan, type II collagen, and SOX-9. The study verified that the chondrogenic-differentiated MSCs derived from human adipose tissues with fibrin glue can proliferate and form new cartilage. Our findings suggest that formation of cartilages in vivo is possible.
The cloud storage ciphertext retrieval scheme based on ORAM

Due to its characteristics distribution and virtualization, cloud storage also brings new security problems. User's data is stored in the cloud, which separated the ownership from management. How to ensure the security of cloud data, how to increase data availability and how to improve user privacy perception are the key issues of cloud storage research, especially when the cloud service provider is not completely trusted. In this paper, a cloud storage ciphertext retrieval scheme based on AES and homomorphic encryption is presented. This ciphertext retrieval scheme will not only conceal the user retrieval information, but also prevent the cloud from obtaining user access pattern such as read-write mode, and access frequency, thereby ensuring the safety of the ciphertext retrieval and user privacy. The results of simulation analysis show that the performance of this ciphertext retrieval scheme requires less overhead than other schemes on the same security level.
The effects of spatial sampling choices on MR temperature measurements

The purpose of this article is to quantify the effects that spatial sampling parameters have on the accuracy of magnetic resonance temperature measurements during high intensity focused ultrasound treatments. Spatial resolution and position of the sampling grid were considered using experimental and simulated data for two different types of high intensity focused ultrasound heating trajectories (a single point and a 4‐mm circle) with maximum measured temperature and thermal dose volume as the metrics. It is demonstrated that measurement accuracy is related to the curvature of the temperature distribution, where regions with larger spatial second derivatives require higher resolution. The location of the sampling grid relative temperature distribution has a significant effect on the measured values. When imaging at 1.0 × 1.0 × 3.0 mm3 resolution, the measured values for maximum temperature and volume dosed to 240 cumulative equivalent minutes (CEM) or greater varied by 17% and 33%, respectively, for the single‐point heating case, and by 5% and 18%, respectively, for the 4‐mm circle heating case. Accurate measurement of the maximum temperature required imaging at 1.0 × 1.0 × 3.0 mm3 resolution for the single‐point heating case and 2.0 × 2.0 × 5.0 mm3 resolution for the 4‐mm circle heating case. Magn Reson Med, 2011. © 2010 Wiley‐Liss, Inc.
Evaluación del potencial probiótico de lactobacilos aislados de heces de lactantes y leche materna

Los probioticos son definidos como microorganismos vivos que cuando se consumen en cantidades apropiadas confieren efectos saludables al hospedador. Dentro los mas utilizados se encuentran las bacterias del genero Lactobacillus. Uno de los principales criterios que deben cumplir las bacterias para ser consideradas probioticas, es ser resistentes a las condiciones del tracto gastrointestinal. El objetivo del presente estudio fue evaluar el potencial probiotico de lactobacilos aislados de muestras de heces de lactantes y leche materna. Fueron evaluadas cuatro cepas de L. paracasei ssp. paracasei y una cepa de L. rhamnosus. Se realizaron pruebas in vitro de resistencia a acidez gastrica, en caldo MRS suplementado con pepsina ajustado a pH 2, 3, 4, y resistencia a sales biliares a 0.05, 0.10, 0.15 y 0.30%, en caldo MRS. Las cepas evaluadas mostraron diferentes grados de resistencia a la acidez gastrica y fueron capaces de multiplicarse en medios con diferentes concentraciones de sales biliares. Los lactobacilos estudiados presentaron comportamientos favorables para ser considerados como potencialmente probioticos, una cepa de L. paracasei ssp. paracasei (71) y una cepa de L. rhamnosus (75) presentaron el mayor potencial
Immunopathologic Features of Pemphigus in the East Mediterranean Region of Turkey : A Prospective Study

ing & Indexing: The journal is indexed in Index Medicus/MEDLINE. Pulse Marketing & Communications, LLC • 4 Peninsula Avenue • Suite 401 • Sea Bright, NJ 07760 • Tel (732) 747-6525 • Fax (732) 747-7010 hisToriCal VigNeTTe Charles Steffen, MD, Section Editor Dermatopathology in Historical Perspective: The Montgomery Giant Cell of Lichen Simplex Chronicus . 54 Svetlana Rubakovic, MD; Charles Steffen, MD
Analysis of the nicastrin promoter rs10752637 polymorphism and its association with Alzheimer’s disease

Alzheimer’s disease (AD) is a common, degenerative form of dementia characterized by the accumulation of plaques containing amyloid β‐peptides (Aβ). Nicastrin (NCSTN) is a type I trans‐membrane glycoprotein and an essential component of γ‐secretase, a multiprotein complex required for the production of the mature form of Aβ. Overexpression of wild‐type NCSTN increases Aβ production, indicating that the strict regulation of NCSTN expression may play a fundamental role in the pathogenesis of AD. In this study we investigated the effect of a single‐nucleotide polymorphism (SNP; rs10752637), located in the promoter region of the NCSTN gene, on NCSTN promoter activity. First, the rs10752637 genotypes were determined in a Chinese population consisting of 462 patients with sporadic AD and 470 normal control subjects. The distributions of the rs10752637 genotypes and allele frequencies were significantly different between the AD and control groups, with the ‐922T allele significantly associated with the occurrence of AD. Reporter assays indicated that the rs10752637 ‐922T allele had a significantly increased promoter activity relative to the ‐922G allele. Furthermore, gel shift assays demonstrated that the ‐922T allele preferentially bound to components of nuclear extracts. Overall, our results indicate that the rs10752637 SNP can likely influence the expression of NCSTN, and that this may be an influencing factor during the pathogenesis of AD.
Organophosphate pesticides: A general review

Pesticides are chemicals to control a variety of pests that can damage crops and livestock and reduce farm productivity. Organophosphate (OP) compounds are a group of pesticides that includes some of the most toxic chemicals used in agriculture. OP toxicity is due to the ability of these compounds to inhibit an enzyme, acetyl cholinesterase at cholinergic junctions of the nervous system. This review will deal with the history and composition, its uses and role in pollution, metabolism of OPs, health impacts, and clinical manifestations of its toxicity, diagnostic methods and treatment. We suggest that in future, the ministry of agriculture of developing countries especially Iran, should concentrate on the optimization and monitoring of usage of OP compounds as pesticides and furthermore, encouraging the farmers to use natural pesticides and organic agriculture rather than chemical pesticides. Also animal feeds and Milk may serve as a vector for the transmission of substances of extrinsic origin which can be potentially toxic to the consumer. These toxins may originate in cow's milk from the ingestion of plants known to contain toxic substances or feeds contaminated with OP pesticides. In this article, OP pesticide pollution in livestock feed, its excretion from animal and general data about OP pesticides are reviewed.
The impact of thiol peroxidases on redox regulation

The biology of glutathione peroxidases and peroxiredoxins is reviewed with emphasis on their role in metabolic regulation. Apart from their obvious function in balancing oxidative challenge, these thiol peroxidases are not only implicated in orchestrating the adaptive response to oxidative stress, but also in regulating signaling triggered by hormones, growth factors and cytokines. The mechanisms presently discussed comprise dampening of redox-sensitive regulatory processes by elimination of hydroperoxides, suppression of lipoxygenase activity, committing suicide to save H2O2 for signaling, direct binding to receptors or regulatory proteins in a peroxidase activity-independent manner, or acting as sensors for hydroperoxides and as transducers of oxidant signals. The various mechanistic proposals are discussed in the light of kinetic data, which unfortunately are scarce. Taking into account pivotal criteria of a meaningful regulatory circuit, kinetic plausibility and specificity, the mechanistic concepts implying a direct sensor/transducer function of the thiol peroxidases appear most appealing. With rate constants for the reaction with hydroperoxide of 105–108 M− 1 s− 1, thiol peroxidases are qualified as kinetically preferred hydroperoxide sensors, and the ability of the oxidized enzymes to react with defined protein thiols lends specificity to the transduction process. The versatility of thiol peroxidases, however, allows multiple ways of interaction with regulatory pathways.
Modeling the nanoscale linear response of superconducting thin films measured by a scanning probe microwave microscope

A localized and strong RF magnetic field, created by a magnetic write head, is used to examine the linear electrodynamic properties of a Nb superconducting film. The complex reflection coefficient of the write head held in close proximity to the films is measured as a function of sample temperature. A model combining a magnetic circuit (magnetic write head inductively coupled to the sample) and transmission line (microwave circuit) is given to interpret the linear response measurement. Additionally, this reflection linear response measurement can be used to determine the temperature dependence of the magnetic penetration depth on a variety of superconductors.