Miracle-dz/UniFAR-FTUs huggingface dataset:
Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction.

BACKGROUND Previous studies have shown improvement in left ventricular function after intracoronary injection of autologous cells derived from bone marrow (BMC) in the acute phase of myocardial infarction. We designed a randomized, controlled trial to further investigate the effects of this treatment. METHODS Patients with acute ST-elevation myocardial infarction of the anterior wall treated with percutaneous coronary intervention were randomly assigned to the group that underwent intracoronary injection of autologous mononuclear BMC or to the control group, in which neither aspiration nor sham injection was performed. Left ventricular function was assessed with the use of electrocardiogram-gated single-photon-emission computed tomography (SPECT) and echocardiography at baseline and magnetic resonance imaging (MRI) 2 to 3 weeks after the infarction. These procedures were repeated 6 months after the infarction. End points were changes in the left ventricular ejection fraction (LVEF), end-diastolic volume, and infarct size. RESULTS Of the 50 patients assigned to treatment with mononuclear BMC, 47 underwent intracoronary injection of the cells at a median of 6 days after myocardial infarction. There were 50 patients in the control group. The mean (+/-SD) change in LVEF, measured with the use of SPECT, between baseline and 6 months after infarction for all patients was 7.6+/-10.4 percentage points. The effect of BMC treatment on the change in LVEF was an increase of 0.6 percentage point (95% confidence interval [CI], -3.4 to 4.6; P=0.77) on SPECT, an increase of 0.6 percentage point (95% CI, -2.6 to 3.8; P=0.70) on echocardiography, and a decrease of 3.0 percentage points (95% CI, 0.1 to -6.1; P=0.054) on MRI. The two groups did not differ significantly in changes in left ventricular end-diastolic volume or infarct size and had similar rates of adverse events. CONCLUSIONS With the methods used, we found no effects of intracoronary injection of autologous mononuclear BMC on global left ventricular function.
Spatially addressable multiprotein nanoarrays templated by aptamer-tagged DNA nanoarchitectures.

Here we generalize a highly programmable strategy to self-assemble multiprotein nanoarrays with deterministic positional addressability. These protein nanoarrays were templated by aptamer-tagged DNA nanoarchitectures. Arrays of proteins with precisely controlled positions and interprotein spacings offer great potential in proteomics, tissue engineering, and medical diagnostics.
Endothelial Dysfunction in Childhood Infection

Background—Atherosclerosis begins in early life, and endothelial dysfunction is recognized as a key initiating event in the development of atherosclerosis. Although infection has been implicated in endothelial dysfunction and atherogenesis, the impact of acute common childhood infections on the vascular endothelium is unknown. Methods and Results—We studied 600 children aged 10 years drawn from the Avon Longitudinal Study of Parents and Children. The children were divided into 3 groups: those with current acute infection (AI; n=135; 73 boys and 62 girls); a convalescent group with infection in the past 2 weeks (n=166; 78 boys and 88 girls), and a healthy control group (n=299; 131 boys and 168 girls). Endothelial function was determined in all subjects by high-resolution ultrasound to measure brachial artery flow-mediated dilation (FMD) and was expressed as the percentage change in diameter from baseline after reactive hyperemia. FMD was repeated in 40 children in the AI group and 50 in the control group after a mean interval of 1 year. FMD was lower in both the AI group (6.3±2.7%, mean±SD) and the convalescent group (8.1±3.1%) than in the control group (9.7±2.5%; P<0.001 for both). The observed differences in FMD remained after adjustment for potential confounding variables. At the repeat visit, FMD was unchanged in controls (P=0.85) but improved in the AI group (P<0.001). Conclusions—Acute infection in childhood is associated with impaired endothelium-dependent vasodilation. These findings support a potential role for previously unsuspected extrinsic inflammatory stimuli in the pathogenesis of early atherosclerosis.
Joint Non-Gaussian Denoising and Superresolving of Raw High Frame Rate Videos

High frame rate cameras capture sharp videos of highly dynamic scenes by trading off signal-noise-ratio and image resolution, so combinational super-resolving and denoising is crucial for enhancing high speed videos and extending their applications. The solution is nontrivial due to the fact that two deteriorations co-occur during capturing and noise is nonlinearly dependent on signal strength. To handle this problem, we propose conducting noise separation and super resolution under a unified optimization framework, which models both spatiotemporal priors of high quality videos and signal-dependent noise. Mathematically, we align the frames along temporal axis and pursue the solution under the following three criterion: 1) the sharp noise-free image stack is low rank with some missing pixels denoting occlusions; 2) the noise follows a given nonlinear noise model; and 3) the recovered sharp image can be reconstructed well with sparse coefficients and an over complete dictionary learned from high quality natural images. In computation aspects, we propose to obtain the final result by solving a convex optimization using the modern local linearization techniques. In the experiments, we validate the proposed approach in both synthetic and real captured data.
Automated characterization and classification of coronary artery disease and myocardial infarction by decomposition of ECG signals: A comparative study

Cardiovascular diseases (CVDs) are the main cause of cardiac death worldwide. The Coronary Artery Disease (CAD) is one of the leading causes of these CVD deaths. CAD condition progresses rapidly, if not diagnosed and treated at an early stage may eventually lead to an irreversible state of heart muscle death called Myocardial Infarction (MI). Normally, the presence of these cardiac conditions is primarily reflected on the electrocardiogram (ECG) signal. However, it is challenging and requires rich experience to manually interpret the visual subtle changes occurring in the ECG waveforms. Thus, many automated diagnostic systems are developed to overcome
An Image-Based Scene Representation and Rendering Framework Incorporating Multiple Representations

A variety of image-based scene representations like light fields, concentric mosaics, panoramas, and omnidirectional video have been proposed in the past years. These image-based scene representations provide photorealistic interactive user navigation in a 3D scene. As the trade-off between acquisition complexity, freedom of movement and rendering quality differs for the diverse techniques, the most efficient scene representation and rendering technique should be selected with respect to scene content and complexity. Splitting a scene into partial representations which are adapted to local requirements is proposed in this paper. Besides meaningful restrictions to user movement, the transition between different image-based scene representations is addressed to provide an efficient image based walkthrough for large and complex scenes. We identify rendering parameters to achieve a seamless transition between different representations and present results for stitching together concentric mosaics, omnidirectional video and light fields.
Virtual worlds are authentic sites for learning

This chapter considers how ‘meaningful learning’ can be understood in the context of knowledge-age skills. Through a study conducted in Second Life™, it investigates whether terms such as ‘authentic’, ‘active’ and ‘collaborative’ can be applied to activities undertaken in virtual worlds. It examines the knowledge-age skills employed in virtual worlds, relating these skills to the characteristics of the learning environment. Finally, it asks whether the distinction between meaningful and non-meaningful learning environments is more important for the development of knowledge-age skills than the distinction between formal and informal situations or between staff-run and student-run situations.
Wavefront outer scale and seeing measurements at San Pedro Mártir Observatory

The first measurements of the spatial coherence outer scale at the Observatorio Astronomico Nacional at San Pedro Martir (OAN-SPM) are reported along with long term seeing measurements. These parameters were measured with the Generalized Seeing Monitor and with a Dierential Image Motion Monitor. An instrumented mast was also used to mea- sure the structure constant of the refractive index C 2 in the first 15 m. Log-normal statistics were found for the seeing and for the outer scale, with median values of 0:92 00 and 27.0 m, respectively. The distribution of the outer scale values is similar to that found in other observatories around the world, suggesting that the presence of trees in the OAN-SPM do not aect the outer scale values. Correlation studies suggest that large values of the seeing and the outer scale are likely to occur when the wind blows from the SSW. Further studies are recommended to confirm this tendency.
Center for International Economics Working Paper Series a Tree-form Constant Market Share Model for Growth Causes in International Trade Based on Multi-level Classification a Tree-form Constant Market Share Model for Growth Causes in International Trade Based on Multi-level Classification

This paper introduces a tree-form constant market share (CMS) model for analyzing growth causes in international trade based on multi-level classification. The tree-form CMS is a collection of CMS models at different levels, including the entire, branch-and leaf-models, which consists of a large amount of information and has a wide application spectrum. Basic properties of this model are investigated in detail. It is shown that the tree-form CMS model is superior to other CMS models in the literature. It is also shown that well known CMS formulations are special cases of a linear class with two parameters, which control how the interaction term is divided into the demand growth and competitive terms. Application to bilateral trade between China and Germany shows that the growth causes in different periods are clearly different. It is shown that the outputs of the tree-form CMS model can be used for further suitable statistical analysis. Furthermore, our theoretical findings are also confirmed by those data examples.
Achievable Performance of Blind Policies in Heavy Traffic

For a GI/GI/1 queue, we show that the average sojourn time under the (blind) Randomized Multilevel Feedback algorithm is no worse than that under the Shortest Remaining Processing Time algorithm times a logarithmic function of the system load. Moreover, it is verified that this bound is tight in heavy traffic, up to a constant multiplicative factor. We obtain this result by combining techniques from two disparate areas: competitive analysis and applied probability.
MMPI-2 characteristics of the Old Order Amish: a comparison of clinical, nonclinical, and United States normative samples.

[Correction Notice: An erratum for this article was reported in Vol 23(4) of Psychological Assessment (see record 2011-12640-001). The article contains an error under the Participants and Procedure heading. This is addressed in the correction. ] In the current study, we investigated Minnesota Multiphasic Personality Inventory-2 (MMPI-2) characteristics in an Old Order Amish nonclinical sample (N = 84), comparing these data with both the United States normative sample (N = 2,600) and a sample of Old Order Amish outpatients (N = 136). Consistent with our hypothesis, the Old Order Amish nonclinical group scored similarly to the United States normative sample and lower than the Old Order Amish outpatients on most scales. Thus, overall, the MMPI-2 appears to be sensitive to psychopathology, especially depression and psychosis, among Old Order Amish test takers. Still, several Validity, Clinical, Supplementary, Content, and Personality Psychopathology Five (PSY-5) scale score differences materialized between the Old Order Amish nonclinical group and the United States group, suggesting that certain MMPI-2 scales may need to be interpreted differently for Old Order Amish test takers. Further MMPI-2 research is needed with the Old Order Amish to replicate and generalize our findings. (PsycINFO Database Record (c) 2011 APA, all rights reserved).
Biosynthesis of lysosomal hydrolases: their synthesis in bound polysomes and the role of co- and post-translational processing in determining their subcellular distribution

By in vitro translation of mRNA’s isolated from free and membrane-bound polysomes, direct evidence was obtained for the synthesis of two lysosomal hydrolases, β-glucuronidase of the rat preputial gland and cathespin D of mouse spleen, on polysomes bound to rough endoplasmic reticulum (ER) membranes. When the mRNA’s for these two proteins were translated in the presence of microsomal membranes, the in vitro synthesized polypeptides were cotranslationally glycosylated and transferred into the microsomal lumen. Polypeptides synthesized in the absence of microsomal membranes were approximately 2,000 daltons larger than the respective unglycosylated microsomal polypeptides found after short times of labeling in cultured rat liver cells treated with tunicamycin. This strongly suggests that nascent chains of the lysosomal enzymes bear transient amino terminal signals which determine synthesis on bound polysomes and are removed during the cotranslational insertion of the polypeptides into the ER membranes. In the line of cultured rat liver cells used for this work, newly synthesized lysosomal hydrolases showed a dual destination; approximately 60 percent of the microsomal polypeptides detected after short times of labeling were subsequently processed proteolytically to lower molecular weight forms characteristic of the mature enzymes. The remainder was secreted from the cells without further proteolytic processing. As previously observed by other investigations in cultured fibroblasts (A. Gonzalez-Noriega, J.H. Grubbs, V. Talkad, and W.S. Sly, 1980, J Cell Biol. 85: 839-852; A. Hasilik and E.F. Neufeld, 1980, J. Biol. Chem., 255:4937-4945.) the lysosomotropic amine chloroquine prevented the proteolytic maturation of newly synthesized hydrolases and enhanced their section. In addition, unglycosylated hydrolases synthesized in cells treated with tunicamycin were exclusively exported from the cells without undergoing proteolytic processing. These results support the notions that modified sugar residues serve as sorting out signals which address the hydrolases to their lysosomal destination and that final proteolytic cleavage of hydrolase precursors take place within lysosome itself. Structural differences in the carbohydrate chains of intracellular and secreted precursors of cathespin D were detected from their differential sensitivity to digestion with endoglycosidases H and D. These observations suggest that the hydrolases exported into the medium follow the normal secretory route and that some of their oligosaccharides are subject to modifications known to affect many secretory glycoproteins during their passage through the Golgi apparatus.
Supporting mixed presence groupware in tabletop applications

In this paper, we present the transparent input device layer framework to extend Java applications with support for multiple distributed input devices, a major requirement for tabletop applications. This overcomes a key restriction of current graphical environments to support only a single system cursor and one keyboard, and allows the cursor and keyboard control of applications to be performed by input devices that are connected to other hosts on the network. Applications can be developed with this framework and therefore allow operations such as simultaneous drag and drop by multiple users. Additionally, we have created a wrapper application to inject support for multiple input devices into legacy applications at runtime - without the need for code alteration or recompilation. We present two tabletop applications that make use of our framework: one is a graphical front end to a military course of action scheduling application and was developed with the framework. The second application, a component based data visualisation application, employs the injection wrapper application to gain support for distributed multiple input devices at runtime.
Conception d'un modèle et de frameworks de distribution d'applications sur grappes de PCs avec tolérance aux pannes à faible coût

Les grappes de PCs constituent des architectures distribuees dont l'adoption se repand a cause de leur faible cout mais aussi de leur extensibilite en termes de noeuds. Notamment, l'augmentation du nombre des noeuds est a l'origine d'un nombre croissant de pannes par arret qui mettent en peril l'execution d'applications distribuees. L'absence de solutions efficaces et portables confine leur utilisation a des applications non critiques ou sans contraintes de temps. MoLOToF est un modele de tolerance aux pannes de niveau applicatif et fondee sur la realisation de sauvegardes. Pour faciliter l'ajout de la tolerance aux pannes, il propose une structuration de l'application selon des squelettes tolerants aux pannes, ainsi que des collaborations entre le programmeur et le systeme de tolerance des pannes pour gagner en efficacite. L'application de MoLOToF a des familles d'algorithmes paralleles SPMD et Maitre-Travailleur a mene aux frameworks FT-GReLoSSS et ToMaWork respectivement. Chaque framework fournit des squelettes tolerants aux pannes adaptes aux familles d'algorithmes visees et une mise en oeuvre originale. FT-GReLoSSS est implante en C++ au-dessus de MPI alors que ToMaWork est implante en Java au-dessus d'un systeme de memoire partagee virtuelle fourni par la technologie JavaSpaces. L'evaluation des frameworks montre un surcout en temps de developpement raisonnable et des surcouts en temps d'execution negligeables en l'absence de tolerance aux pannes. Les experiences menees jusqu'a 256 noeuds sur une grappe de PCs bi-coeurs, demontrent une meilleure efficacite de la solution de tolerance aux pannes de FT-GReLoSSS par rapport a des solutions existantes de niveau systeme (LAM/MPI et DMTCP).
Patterns Support for Automatic Resource Management in Cloud Computing

Cloud computing has become a popular topic in many areas. It can publish various resources offered by a number of vendors as services. However, there is no valid technology to manage the resources or services. In this paper, the relations among the resources are classified into four classes: the relations among the resources having the same character, the relations among the variable part and invariable part of a service, the relations among the resources having the same interaction manner, and the relations among the resources that are incompatible but have to interoperate. Then four patterns are proposed to manage the resources in cloud. The motivation, condition, structure, generation and consequence are presented for each pattern. They can be used to improve the availability, scalability and reusability of the resources provided.
64-Channel Cardiac Computed Tomography: Intraobserver and Interobserver Variability, Part 2: Global and Regional Ventricular Function, Mass, and First Pass Perfusion

Objectives: To assess intraobserver and interobserver variability in cardiac computed tomographic measurements of global biventricular function, left ventricular (LV) regional wall motion, systolic wall thickening, and first pass perfusion in 3 patient cohorts at very low, low to intermediate, and intermediate to high cardiac risk. Methods: One hundred thirty-three patients underwent 64-channel cardiac computed tomography. Images were analyzed by 2 experienced, blinded observers. Intraobserver and interobserver agreements were calculated for each cohort and were combined for patients with structurally normal hearts. Results: Intraobserver and interobserver agreements were good for all global and regional LV parameters with narrow levels of agreement. Right ventricular ejection fraction agreement was also good, but other right ventricular parameters showed wide levels of agreement. Conclusions: Biventricular ejection fraction, LV regional wall motion, and systolic wall thickening, volume, and mass show good reproducibility for use in standard clinical practice. Right ventricular volumetric and mass data in patients with congenital heart disease should be interpreted with caution.
Web site auditing: first step towards re-engineering

There is a growing demand for redesigning the existing Web sites. Many organisations want their sites evaluated, or audited, with recommendations to improve them. Historically, auditing has related to financial matters. It is now applied to other disciplines such as quality, environment, safety, information systems and security. Correspondingly, there are many national and international standards for such audits. Operationally, a financial audit is an independent and expert opinion on how an organisation handles its resources and may recommend, if necessary, changes in the organisational practices to meet the established standards and obligations. In contrast, a Quality audit is meant to aid continuous improvement strategies. The definition and role of a Web site audit are not so clear. This paper addresses these two problems. First, it establishes a general context for Web site auditing in terms of the types of Web-based systems, the stages of Web development and the need for frequent re-engineering of the existing sites. The paper then argues that Web site auditing, as currently understood, is qualitatively different from normal auditing and recommends that it be an integral part of the re-engineering strategy and not be seen as mainly a reassurance exercise.
Comparison of Eyes Characteristics in Different Color Spaces

Eye characteristics are significant information in pattern recognition. They are widely applied in many fields, such as human-computer interaction, face recognition and 3D face modeling from 2D images. Generally, the eye information detection is Based on gray images. However, color images provide more information than gray images. According to different applications, choosing a suitable color space is very important. In this paper, several eye features are compared from the view point of different color spaces, such as RGB, HIS, HSV. And some experiments have been done in the three color spaces. The extraordinary bright area of pupil in the H channel of HSV color space is confirmed. Moreover, pupil center is detected and estimated using morphology processing method in H channel. The results show that eyes features are more obvious in the HSV space, and feature extraction is more convenient. Furthermore, the experimental analysis can provide reference for future research on eye characteristic recognition.