Miracle-dz/UniFAR-FTUs huggingface dataset:
The influence of uncemented femoral stem length and design on its primary stability: a finite element analysis

One of the crucial factors for short- and long-term clinical success of total hip arthroplasty cementless implants is primary stability. Indeed, motion at the bone–implant interface above 40 μm leads to partial bone ingrowth, while motion exceeding 150 μm completely inhibits bone ingrowth. The aim of this study was to investigate the effect of two cementless femoral stem designs with different lengths on the primary stability. A finite element model of a composite Sawbones® fourth generation, implanted with five lengths of the straight prosthesis design and four lengths of the curved prosthesis design, was loaded with hip joint and abductor forces representing two physiological activities: fast walking and stair climbing. We found that reducing the straight stem length from 146 to 54 mm increased the average micromotion from 17 to 52 μm during fast walking, while the peak value increased from 42 to 104 μm. With the curved stem, reducing length from 105 to 54 mm increased the average micromotion from 10 to 29 μm, while the peak value increased from 37 to 101 μm. Similar findings are obtained for stair climbing for both stems. Although the present study showed that femoral stem length as well as stem design directly influences its primary stability, for the two femoral stems tested, length could be reduced substantially without compromising the primary stability. With the aim of minimising surgical invasiveness, newer femoral stem design and currently well performing stems might be used with a reduced length without compromising primary stability and hence, long-term survivorship.
Scintillating Balloon-Enabled Fiber-Optic System for Radionuclide Imaging of Atherosclerotic Plaques

Atherosclerosis underlies coronary artery disease, the leading cause of death in the United States and worldwide. Detection of coronary plaque inflammation remains challenging. In this study, we developed a scintillating balloon-enabled fiber-optic radionuclide imaging (SBRI) system to improve the sensitivity and resolution of plaque imaging using 18F-FDG, a marker of vascular inflammation, and tested it in a murine model. Methods: The fiber-optic system uses a Complementary Metal-Oxide Silicon (CMOS) camera with a distal ferrule terminated with a wide-angle lens. The novelty of this system is a scintillating balloon in the front of the wide-angle lens to image light from the decay of 18F-FDG emission signal. To identify the optimal scintillating materials with respect to resolution, we calculated the modulation transfer function of yttrium–aluminum–garnet doped with cerium, anthracene, and calcium fluoride doped with europium (CaF2:Eu) phosphors using an edge pattern and a thin-line optical phantom. The scintillating balloon was then fabricated from 10 mL of silicone RTV catalyst mixed with 1 mL of base and 50 mg of CaF2:Eu per mL. The addition of a lutetium oxyorthosilicate scintillating crystal (500 μm thick) to the balloon was also investigated. The SBRI system was tested in a murine atherosclerosis model: carotid-ligated mice (n = 5) were injected with 18F-FDG, followed by ex vivo imaging of the macrophage-rich carotid plaques and nonligated controls. Confirmatory imaging of carotid plaques and controls was also performed by an external optical imaging system and autoradiography. Results: Analyses of the different phosphors showed that CaF2:Eu enabled the best resolution of 1.2 μm. The SBRI system detected almost a 4-fold-higher radioluminescence signal from the ligated left carotid artery than the nonligated right carotid: 1.63 × 102 ± 4.01 × 101 vs. 4.21 × 101 ± 2.09 × 100 (photon counts), P = 0.006. We found no significant benefit to adding a scintillating crystal to the balloon: 1.65 × 102 ± 4.07 × 101 vs. 4.44 × 101 ± 2.17 × 100 (photon counts), P = 0.005. Both external optical imaging and autoradiography confirmed the high signal from the 18F-FDG in carotid plaques versus controls. Conclusion: This SBRI system provides high-resolution and sensitive detection of 18F-FDG uptake by murine atherosclerotic plaques.
The lifetime risk of stroke: estimates from the Framingham Study.

BACKGROUND AND PURPOSE The lifetime risk (LTR) of stroke has not been reported for the United States population; such data would assist public education and health planning. METHODS Framingham Original cohort participants (n=4897) who were stroke- and dementia-free at 55 years of age were followed biennially for up to 51 years (115 146 person years). We estimated the sex-specific 10-, 20-, and 30-year risks and LTR of developing a stroke by baseline age and blood pressure (BP) and compared it with the risk of developing Alzheimer disease (AD). RESULTS A total of 875 participants (522 women) developed a first-ever stroke; 749 (448 women) had an ischemic stroke. LTR of stroke was high and remained similar at ages 55, 65, and 75 years, approximating 1 in 5 for women and 1 in 6 for men. Participants with a normal BP (<120/80 mm Hg) had approximately half the LTR of stroke compared with those with high BP (> or =140/90 mm Hg). The LTR of AD at age 65 (292 participants; 211 women) approximated 1 in 5 for women and 1 in 10 for men. The LTR of developing either stroke or dementia approximated 1 in 3 in both sexes. CONCLUSIONS The LTR of stroke in middle-aged adults is 1 in 6 or more, which is equal to or greater than the LTR of AD. Women had a higher risk because of longer life expectancy. BP is a significant determinant of the LTR of stroke, and promotion of normal BP levels in the community might be expected to substantially reduce this risk.
Structural Insight into the Critical Role of the N-Terminal Region in the Catalytic Activity of Dual-Specificity Phosphatase 26

Human dual-specificity phosphatase 26 (DUSP26) is a novel target for anticancer therapy because its dephosphorylation of the p53 tumor suppressor regulates the apoptosis of cancer cells. DUSP26 inhibition results in neuroblastoma cell cytotoxicity through p53-mediated apoptosis. Despite the previous structural studies of DUSP26 catalytic domain (residues 61–211, DUSP26-C), the high-resolution structure of its catalytically active form has not been resolved. In this study, we determined the crystal structure of a catalytically active form of DUSP26 (residues 39–211, DUSP26-N) with an additional N-terminal region at 2.0 Å resolution. Unlike the C-terminal domain-swapped dimeric structure of DUSP26-C, the DUSP26-N (C152S) monomer adopts a fold-back conformation of the C-terminal α8-helix and has an additional α1-helix in the N-terminal region. Consistent with the canonically active conformation of its protein tyrosine phosphate-binding loop (PTP loop) observed in the structure, the phosphatase assay results demonstrated that DUSP26-N has significantly higher catalytic activity than DUSP26-C. Furthermore, size exclusion chromatography-multiangle laser scattering (SEC-MALS) measurements showed that DUSP26-N (C152S) exists as a monomer in solution. Notably, the crystal structure of DUSP26-N (C152S) revealed that the N-terminal region of DUSP26-N (C152S) serves a scaffolding role by positioning the surrounding α7-α8 loop for interaction with the PTP-loop through formation of an extensive hydrogen bond network, which seems to be critical in making the PTP-loop conformation competent for phosphatase activity. Our study provides the first high-resolution structure of a catalytically active form of DUSP26, which will contribute to the structure-based rational design of novel DUSP26-targeting anticancer therapeutics.
Low complexity power and scheduling policies for wireless networks to provide quality of service

We consider optimal power allocation policies for a single server, multiuser system. The power is consumed in transmission of data only. The transmission channel may experience multipath fading. We obtain very efficient, low computational complexity algorithms which minimize power and ensure stability of the data queues. We also obtain policies when the users may have mean delay constraints. If the power required is a linear function of rate then we exploit linearity and obtain linear programs with low complexity.
TCR Gene Therapy of Spontaneous Prostate Carcinoma Requires In Vivo T Cell Activation1

Analogous to the clinical use of recombinant high-affinity Abs, transfer of TCR genes may be used to create a T cell compartment specific for self-Ags to which the endogenous T cell repertoire is immune tolerant. In this study, we show in a spontaneous prostate carcinoma model that the combination of vaccination with adoptive transfer of small numbers of T cells that are genetically modified with a tumor-specific TCR results in a marked suppression of tumor development, even though both treatments are by themselves without effect. These results demonstrate the value of TCR gene transfer to target otherwise nonimmunogenic tumor-associated self-Ags provided that adoptive transfer occurs under conditions that allow in vivo expansion of the TCR-modified T cells.
Hybrid Cellular/WLAN with Wireless Offloading: Enabling Next Generation Wireless Networks

The exploitation of already deployed wireless local area networks (WLAN)s (e.g., WiFi access points (AP)s) has attracted considerable attention, as an efficient and practical method to improve the performance of beyond 4G wireless networks. In this paper, we propose a novel communication paradigm to satisfy the performance demands of future wireless networks: a hybrid Cellular/WLAN network architecture with wireless offloading. In contrast to the commonly adopted practice of WiFi offloading, where the WLAN APs have a wired backhaul (e.g., Digital Subscriber Line), we propose a wireless offloading approach, where the WLAN APs will share their wireless cellular broadband connection with other users. These users will select their serving node, i.e., the macro-cell eNodeB or a WLAN AP, based on a certain selection criterion. Thus a challenging research field is originated, where interfering effects and wireless resources limitations play a dominant role. Important performance metrics of the proposed hybrid scheme, including the bit error probability, the ergodic capacity and the average signal-to-interference-plus noise ratio, are theoretically studied and closed form expressions are derived for the single-user case with multiple interferers, for both identical and non-identical fading conditions. Also, based on the general multi-cellular hybrid WLAN-Cellular concept, we first propose a intercell interference minimization approach. Then we present a novel scheme for achieving frequency reuse equal to one within a single macro-cell, under specific performance criteria and constraints, that guarantee the overall cell or the individual user QoS requirements.
The influence of low donor age, living related donation and pre-emptive transplantation on end-organ damage based on arterial hypertension after paediatric kidney transplantation.

BACKGROUND To date, no study has described the pre-transplant and transplant risk factors for end-organ damage based on arterial hypertension in children after kidney transplantation (KTX). METHODS A retrospective chart review was performed of 206 children with KTX between 1991 and 2007. Patients<120 cm were excluded as no validated percentiles for 24-h ambulant blood pressure monitoring (ABPM) exist. Complete data sets were available for 116 patients. Data were recorded at 12, 24 and 36 months post- KTX. We analysed the influence of donor age, age at transplantation, pre-emptive transplantation, living or deceased transplantation and glomerular filtration rate (GFR) on the presence of end-organ damage, ABPM, ABPM standard deviation score and the numbers of anti-hypertensives used. RESULTS Lower donor age and the decade of transplantation were associated with less detection of end-organ damage (P=0.001). A lower need for anti-hypertensive medication (P=0.001) was detected in children who received organs from living donors and from deceased donors with a donor age<35 years and who were transplanted pre-emptively. Low recipient age was the only factor associated with lower ABPM (P=0.001). In our study, the type of immunosuppressive regimen and the GFR had no influence on the blood pressure. CONCLUSIONS It may be speculated that the risk of arterial hypertension and associated end-organ damage in children after KTX could be reduced by using organs from young donors with an advantage for living related and pre-emptive donation.
A fresh look at programming with names and binders

A wide range of computer programs, including compilers and theorem provers, manipulate data structures that involve names and binding. However, the design of programming idioms which allow performing these manipulations in a safe and natural style has, to a large extent, remained elusive. In this paper, we present a novel approach to the problem. Our proposal can be viewed either as a programming language design or as a library: in fact, it is currently implemented within Agda. It provides a safe and expressive means of programming with names and binders. It is abstract enough to support multiple concrete implementations: we present one in nominal style and one in de Bruijn style. We use logical relations to prove that "well-typed programs do not mix names with different scope". We exhibit an adequate encoding of Pitts-style nominal terms into our system.
Representation of Homothetic Forward Performance Processes in Stochastic Factor Models Via Ergodic and Infinite Horizon BSDE

In an incomplete market, with incompleteness stemming from stochastic factors imperfectly correlated with the underlying stocks, we derive representations of homothetic (power, exponential, and logarithmic) forward performance processes in factor-form using ergodic BSDE. We also develop a connection between the forward processes and infinite horizon BSDE, and, moreover, with risk-sensitive optimization. In addition, we develop a connection, for large time horizons, with a family of classical homothetic value function processes with random endowments.
Visualization of faces from surveillance videos via face hallucination

Face hallucination can be a useful tool for visualizing a low quality face into a visually better quality, making it an attractive technology for many applications. While faces in surveillance videos are usually at very low resolution, in this paper, we propose to use face hallucination technology to visualize faces from visual surveillance systems, and develop a weighted scheme to enhance the quality of face visualization from surveillance videos. Our experiment validated that in comparison with the classic eigenspace based face hallucination, our proposed weighted face hallucination strategy can help improve the overall quality of a facial image extracted from surveillance footage.
Distributed Ranging and Localization for Wireless Networks via Compressed Sensing

Location-based services in a wireless network require nodes to know their locations accurately. Conventional solutions rely on contention-based medium access, where only one node can successfully transmit at any time in any neighborhood. In this paper, a novel, complete, distributed ranging and localization solution is proposed, which let all nodes in the network broadcast their location estimates and measure distances to all neighbors simultaneously. An on-off signaling is designed to overcome the physical half-duplex constraint. In each iteration, all nodes transmit simultaneously, each broadcasting codewords describing the current location estimate. From the superposed signals from all neighbors, each node decodes their neighbors' locations and also estimates their distances using the signal strengths. The node then broadcasts its improved location estimates in the subsequent iteration. Simulations demonstrate accurate localization throughout a large network over a few thousand symbol intervals, suggesting much higher efficiency than conventional schemes based on ALOHA or CSMA.
NaviBike: Comparing Unimodal Navigation Cues for Child Cyclists

Navigation systems for cyclists are commonly screen-based devices mounted on the handlebar which show map information. Typically, adult cyclists have to explicitly look down for directions. This can be distracting and challenging for children, given their developmental differences in motor and perceptual-motor abilities compared with adults. To address this issue, we designed different unimodal cues and explored their suitability for child cyclists through two experiments. In the first experiment, we developed an indoor bicycle simulator and compared auditory, light, and vibrotactile navigation cues. In the second experiment, we investigated these navigation cues in-situ in an outdoor practice test track using a mid-size tricycle. To simulate road distractions, children were given an additional auditory task in both experiments. We found that auditory navigational cues were the most understandable and the least prone to navigation errors. However, light and vibrotactile cues might be useful for educating younger child cyclists.
Modulation of Lactobacillus plantarum Gastrointestinal Robustness by Fermentation Conditions Enables Identification of Bacterial Robustness Markers

Background Lactic acid bacteria (LAB) are applied worldwide in the production of a variety of fermented food products. Additionally, specific Lactobacillus species are nowadays recognized for their health-promoting effects on the consumer. To optimally exert such beneficial effects, it is considered of great importance that these probiotic bacteria reach their target sites in the gut alive. Methodology/Principal Findings In the accompanying manuscript by Bron et al. the probiotic model organism Lactobacillus plantarum WCFS1 was cultured under different fermentation conditions, which was complemented by the determination of the corresponding molecular responses by full-genome transcriptome analyses. Here, the gastrointestinal (GI) survival of the cultures produced was assessed in an in vitro assay. Variations in fermentation conditions led to dramatic differences in GI-tract survival (up to 7-log) and high robustness could be associated with low salt and low pH during the fermentations. Moreover, random forest correlation analyses allowed the identification of specific transcripts associated with robustness. Subsequently, the corresponding genes were targeted by genetic engineering, aiming to enhance robustness, which could be achieved for 3 of the genes that negatively correlated with robustness and where deletion derivatives displayed enhanced survival compared to the parental strain. Specifically, a role in GI-tract survival could be confirmed for the lp_1669-encoded AraC-family transcription regulator, involved in capsular polysaccharide remodeling, the penicillin-binding protein Pbp2A involved in peptidoglycan biosynthesis, and the Na+/H+ antiporter NapA3. Moreover, additional physiological analysis established a role for Pbp2A and NapA3 in bile salt and salt tolerance, respectively. Conclusion Transcriptome trait matching enabled the identification of biomarkers for bacterial (gut-)robustness, which is important for our molecular understanding of GI-tract survival and could facilitate the design of culture conditions aimed to enhance probiotic culture robustness.
Thermomechanical Actuator-Based Three-Axis Optical Scanner for High-Speed Two-Photon Endomicroscope Imaging

This paper presents the design and characterization of a three-axis thermomechanical actuator-based endoscopic scanner for obtaining ex vivo two-photon images. The scanner consisted of two sub-systems: 1) an optical system (prism, gradient index lens, and optical fiber) that was used to deliver and collect light during imaging and 2) a small-scale silicon electromechanical scanner that could raster scan the focal point of the optics through a specimen. The scanner can be housed within a 7 mm Ø endoscope port and can scan at the speed of 3 kHz x 100 Hz × 30 Hz along three axes throughout a 125 × 125 × 100 μm3 volume. The high-speed thermomechanical actuation was achieved through the use of geometric contouring, pulsing technique, and mechanical frequency multiplication (MFM), where MFM is a new method for increasing the device cycling speed by pairing actuators of unequal forward and returning stroke speeds. Sample cross-sectional images of 15-μm fluorescent beads are presented to demonstrate the resolution and optical cross-sectioning capability of the two-photon imaging system.
Rate-Distortion Theory for Clustering in the Perceptual Space

How to extract relevant information from large data sets has become a main challenge in data visualization. Clustering techniques that classify data into groups according to similarity metrics are a suitable strategy to tackle this problem. Generally, these techniques are applied in the data space as an independent step previous to visualization. In this paper, we propose clustering on the perceptual space by maximizing the mutual information between the original data and the final visualization. With this purpose, we present a new information-theoretic framework based on the rate-distortion theory that allows us to achieve a maximally compressed data with a minimal signal distortion. Using this framework, we propose a methodology to design a visualization process that minimizes the information loss during the clustering process. Three application examples of the proposed methodology in different visualization techniques such as scatterplot, parallel coordinates, and summary trees are presented.
Baseband Trellis-Coded Modulation with Combined Equalization/Decoding for High Bit Rate Digital Subscriber Loops

The authors present a simulation study evaluating the performance of trellis-coded modulation with combined code/ISI sequence estimation for high bit rate (800 kb/s) transmission on subscriber loops. The receiver contains a fractionally spaced forward filter of a decision feedback equalizer (DFE) as a front end. This is shown to suppress phase synchronized crosstalk very effectively. The performance is further enhanced by the use of trellis code with a large number of states received with an M algorithm sequence-estimating receiver with a smaller number of states. >
Coevolutionary genetic algorithms for Ad hoc injection networks design optimization

When considering realistic mobility patterns, nodes in mobile ad hoc networks move in such a way that the networks most often get divided in a set of disjoint partitions. This presence of partitions is an obstacle to communication within these networks. Ad hoc networks are generally based on technologies allowing nodes in a geographical neighborhood to communicate for free, in a P2P manner. These technologies include IEEE802.11 (Wi-Fi), Bluetooth, etc. In most cases a communication infrastructure is available. It can be a set of access point as well as GMS/UMTS network. The use of such an infrastructure is billed, but it permits distant nodes to get in communication, through what we call "bypass links". The objective of our work is to improve the network connectivity by defining a set of long distance connections. To do this we consider the number of bypass links, as well as the two properties that build on the "small-world" graph theory: the clustering coefficient, and the characteristic path length. A fitness function, used for genetic optimization, is processed out of these three metrics. In this paper we investigate the use of two coevolutionary genetic algorithms (LCGA and CCGA) and compare their performance to a generational and a steady- state genetic algorithm (genGA and ssGA) for optimizing one instance of this topology control problem and present evidence of their capacity to solve it.