Miracle-dz/UniFAR-FTUs huggingface dataset:
The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001

The prevalence of obesity, an established risk and progression factor for postmenopausal breast cancer, remains high in US women. Activation of Akt/mammalian target of rapamycin (mTOR) signaling plays a key role in the obesity–breast cancer link. However, the impact of weight normalization in obese postmenopausal women on breast tumorigenesis and/or Akt/mTOR activation is poorly characterized. To model this, ovariectomized female C57BL/6 mice were fed a control diet (n = 20), a calorie restriction (CR) regimen (n = 20), or a diet‐induced obesity (DIO) diet (n = 30). At week 17, DIO mice were switched to control diet, resulting in formerly obese (FOb) mice with weights identical to the controls by week 20. MMTV‐Wnt‐1 mammary tumor cells were injected at 20 wk into each mouse. Two weeks post‐injection, vehicle or the mTOR inhibitor RAD001 at 10 or 15 mg/kg body weight (n = 10/diet group) was administered by gavage twice/week until termination. Relative to controls, CR mice had decreased (and DIO mice had increased) serum insulin‐like growth factor‐1 (IGF‐1) and phosphorylation of Akt/mTOR pathway components. RAD001 decreased tumor growth in the CR, control, and FOb mice. Wnt‐1 tumor cells treated in vitro with serum from mice from each group established that diet‐dependent circulating factors contribute to tumor growth and invasiveness. These findings suggest weight normalization in obese mice does not immediately reverse tumor progression or Akt/mTOR activation. Treatment with RAD001 blocked mammary tumor development and mTOR activation observed in the FOb mice, suggesting combination of lifestyle and pharmacologic strategies may be effective for breaking the obesity–breast cancer link. © 2012 Wiley Periodicals, Inc.
An Add-On for Managing Behaviours with Priority in JADE

In this article, two new implementations for behaviours in JADE are presented. These new behaviours, while being able to reproduce the functioning of the old JADE's behaviours, allow the user to define priorities. This fact is of vital importance for several multiagent applications. Finally, a test was developed to show that the performance of the new behaviours is similar to the original ones.
Application of fluorescence in situ hybridization for the study and characterization of nitrifying bacteria in nitrifying/denitrifying wastewater treatment plants

The aim of this study was to verify fluorescence in situ hybridization for the detection of nitrifying bacteria in activated sludge and biofilms, and to determine the distribution of nitrifiers in selected wastewater treatment plants (WWTPs). Both Czech and foreign WWTPs with intensification of nitrification (for example, in situ bioaugmentation of nitrification or biofilms) and without intensification were studied. The two-dimensional and three-dimensional analyses of microscopic images were focused on quantifying the parameters and their differences with regard to the arrangement, capacity and sludge age of the WWTPs. This is the first time such a study has been performed in the Czech Republic.
The use of Literature Review in Informatics in Education: a Systematic Mapping

Uma Pesquisa Bibliografica (PB) e um procedimento que visa identificar pesquisas ja publicadas, o estado da arte, tendencias ou lacunas sobre um determinado tema com vistas na extensao do conhecimento cientifico. Existem, pelo menos, 4 metodos de PB: tradicional, bibliometrica, mapeamento e, revisao. Quando executadas de forma sistematica as PBs apresentam maior rigor cientifico, maior confiabilidade, maior imparcialidade e maior reproducibilidade, apesar de exigirem a adocao e registro de uma quantidade maior de passos durante a sua realizacao. Este artigo tem como objetivo identificar quantos e quais metodos de PB estao sendo utilizados na area de Informatica na Educacao no Brasil e avaliar como estes estao sendo conduzidos. Para tal, foi executado mapeamento sistematico das publicacoes da area no Brasil, nos ultimos 10 anos. Um total de 3149 artigos oriundos de 4 revistas e 4 eventos da area no pais foram avaliados resultando na identificacao de 17 trabalhos que eram mapeamento ou revisoes sistematicas, mesmo que isto nao fosse evidente pelos seus titulos. Os resultados indicam que o numero de artigos de PB vem aumentando como um todo, em especial as PB sistematicas mas, a PB tradicional ainda e a mais frequente. Foi evidenciada uma proliferacao de termos usados para identificar artigos de PB e que estes podem ser encontrados em varias sub-areas. Os dados tambem indicam que ha uma falta de uniformidade e rigor nos procedimentos e ate desacordo com a terminologia (alguns artigos se auto-denominaram erroneamente conforme os criterios desta pesquisa) a ponto de dificultar uma pesquisa terciaria como esta. Concluimos que a comunidade cientifica de Informatica na Educacao se beneficiaria de (a) um maior rigor na execucao de PBs e, (b) da concentracao dos artigos num unico portal com recursos de busca. Estas medidas certamente facilitaria o desenvolvimento da area como um todo no Brasil.
Effects of CYP3A5, ABCB1 and POR*28 polymorphisms on pharmacokinetics of tacrolimus in the early period after renal transplantation

Abstract 1. We aimed to establish a population pharmacokinetic (PK) model of tacrolimus and identify clinical covariates, especially the genetic polymorphisms of CYP3A5, ABCB1 and POR*28 that affected the PK to prevent fluctuation in the trough concentration of tacrolimus during the early period after renal transplantation. 2. Tacrolimus trough concentration, clinical data and CYP3A5/ABCB1/POR28 genotypes were retrospectively collected from 234 kidney transplant recipients during the first month post-transplantation. The population PK model was built using the non-linear mixed effects modeling software NONMEM. Dosing simulation was performed based on the final model. 3. A one-compartment model with first-order absorption and elimination was used to characterize the PK of tacrolimus. Among the genotypes, only CYP3A5 genotype was confirmed to have clinical significance. The final model describing CL/F (l/h) was as follows: The inter-individual variability in CL/F was 21.9%. Monte Carlo simulation based on the final model was carried out to determine the optimal dosage regimen. 4. CYP3A5 genotype, post-operative day and hematocrit were confirmed as critical PK factors of tacrolimus. The model could be used to accurately predict individual PK parameters of tacrolimus and provide valuable insights into the dosage optimization.
Proinflammatory Cytokines Secreted by Monocytes of Filarial Patients

The levels of interleukin 1, granulocyte macrophage colony stimulating factor (GM‐CSF) and tumour necrosis factor (TNF)‐α secreted by the monocytes of filarial patients, such as asymptomatic microfilaremics (MF), chronic pathology (CP), and normal individuals, residing in a Wuchereria bancrofti endemic area (EN) in response to whole Brugia malayi antigen (BmA) and Setaria digitata (Sd‐cuticular) and a recombinant filarial antigen (pRJ51) were studied. Stimulation of peripheral blood adherent cells with whole parasite antigen showed marked increase in IL‐1 levels in MF as compared to CP or EN. The recombinant antigen stimulation, however, resulted in similar levels of IL‐1 in MF and CP. In contrast, stimulation of peripheral blood adherent cells with whole parasite antigen produced high levels of GM‐CSF and TNF‐α in CP as opposed to MF or EN. Recombinant antigen stimulation, however, produced high levels of GM‐CSF in EN as compared to MF or CP, while no significant change in the release of TNF‐α was observed in these patients. These results suggest that monocytes from filarial patients exhibit functional activity similar to that observed by the monocytes of endemic normals (control group).
Autoestima y rendimiento académico en estudiantes de enfermería de Poza Rica, Veracruz, México

El articulo se origina de los resultados de investigacion obtenidos con el proyecto «Autoestima y rendimiento academico», cuyo objetivo general fue determinar la relacion que existe entre ambas variables en estudiantes de la Facultad de Enfermeria de Poza Rica de la Universidad Veracruzana. Fue un estudio correlacional con valor explicativo. La autoestima fue valorada con la aplicacion del Inventario de Autoestima de Coopersmith. En cuanto al rendimiento academico, se obtuvieron los promedios ponderados semestrales a traves del kardex. Hay resultados que podemos destacar: el 19% de los estudiantes tiene autoestima alta, de los cuales el 16% obtiene un rendimiento academico entre bueno y excelente, y el 3%, entre regular y bajo. Lo cual permite inferir, con Rogers (2000) la importancia del concepto de si mismo y de autoestima positiva en los procesos cognitivos y afectivos de los estudiantes. De ahi la necesidad de incrementaren el universitario su nivel de autoestima.
Processing efficiency theory in children: Working memory as a mediator between trait anxiety and academic performance

Abstract Working memory skills are positively associated with academic performance. In contrast, high levels of trait anxiety are linked with educational underachievement. Based on Eysenck and Calvo's (1992) processing efficiency theory (PET), the present study investigated whether associations between anxiety and educational achievement were mediated via poor working memory performance. Fifty children aged 11–12 years completed verbal (backwards digit span; tapping the phonological store/central executive) and spatial (Corsi blocks; tapping the visuospatial sketchpad/central executive) working memory tasks. Trait anxiety was measured using the State–Trait Anxiety Inventory for Children. Academic performance was assessed using school administered tests of reasoning (Cognitive Abilities Test) and attainment (Standard Assessment Tests). The results showed that the association between trait anxiety and academic performance was significantly mediated by verbal working memory for three of the six academic performance measures (math, quantitative and non-verbal reasoning). Spatial working memory did not significantly mediate the relationship between trait anxiety and academic performance. On average verbal working memory accounted for 51% of the association between trait anxiety and academic performance, while spatial working memory only accounted for 9%. The findings indicate that PET is a useful framework to assess the impact of children's anxiety on educational achievement.
Modulation of Androgen Receptor Transactivation by the SWI3-Related Gene Product (SRG3) in Multiple Ways

ABSTRACT The SWI3-related gene product (SRG3), a component of the mouse SWI/SNF complex, has been suggested to have an alternative function. Here, we demonstrate that in the prostate transactivation of the androgen receptor (AR) is modulated by SRG3 in multiple ways. The expression of SRG3, which is developmentally regulated in the prostate, is induced by androgen through AR. SRG3 in turn enhances the transactivation of AR, providing a positive feedback regulatory loop. The SRG3 coactivation of AR transactivation is achieved through the recruitment of coactivator SRC-1, the protein level of which is upregulated by SRG3, providing another pathway of positive regulation. Interestingly, SRG3 coactivation of AR transactivation is fully functional in BRG1/BRM-deficient C33A cells and the AR/SRG3/SRC-1 complex formed in vivo contains neither BRG1 nor BRM protein, suggesting the possibility of an SRG3 function independent of the SWI/SNF complex. Importantly, the AR/SRG3/SRC-1 complex occupies androgen response elements on the endogenous SRG3 and PSA promoter in an androgen-dependent manner in mouse prostate and LNCaP cells, respectively, inducing gene expression. These results suggest that the multiple positive regulatory mechanisms of AR transactivation by SRG3 may be important for the rapid proliferation of prostate cells during prostate development and regeneration.
Improved Z-Source Inverter With Reduced Z-Source Capacitor Voltage Stress and Soft-Start Capability

This paper proposes an improved Z-source inverter topology. Compared to the traditional Z-source inverter, it can reduce the Z-source capacitor voltage stress significantly to perform the same voltage boost, and has inherent limitation to inrush current at startup. The control strategy of the proposed Z-source inverter is exactly the same as the traditional one, so all the existing control strategy can be used directly. A soft-start strategy is also proposed to suppress the inrush surge and the resonance of Z-source capacitors and inductors. The operation principle of the proposed topology and comparison with the traditional topology are analyzed in detail. Simulation and experimental results are given to demonstrate the new features of the improved topology.
Down to the bone: A corpus-based critical discourse analysis of pro-eating disorder blogs

The pro-eating-disorder community is almost exclusively an online community of individuals who claim that eating disorders are not an illness, but rather a lifestyle choice. This study offers an insight into the ideologies constructed in the pro-eating-disorder online discourse by using micro and macro levels of critical discourse analysis (CDA) on 19 blogs written by the self-declared members of the community. Linguistic analysis of the pro-eating-disorder discourse has been largely under-represented and this study is the first to use a corpus-linguistics approach to CDA in analysing the websites’ content. The results of the analysis show that the pro-eating-disorder community constructs the ideology of eating disorders as a life-style via demedicalised reference to the illness. The study also elaborates on the construction of the negative image of “an outsider” (any person not belonging to the community) as an element of self-determination. By using the corpus linguistic technique of keyness, main topics of the discourse are identified, suggesting relevant relations between the discourse of measuring and will power and the underlying pro-eating-disorder ideologies.
Cross-layer design in opportunistic spectrum access-based cognitive radio networks

Cognitive radio is considered as one of the most important enablers for achieving enhanced spectral efficiency in wireless communications. In this work, we present a cross-layer design for reliable data transmission over a cognitive radio network which combines adaptive modulation at the physical layer and hybrid automatic repeat request at the data link layer. The cognitive radio network follows the principles of opportunistic spectrum access that utilises an optimal power adaptation policy for channel allocation. The obtained numerical results denote that the considered approach achieves significant spectral efficiency improvement and therefore it could be deployed in wireless communication networks that encompass cognitive capabilities. Furthermore, we assess the introduced interference and we show that it can be kept within levels that do not jeopardise our design.
Differences in Sexual Guilt and Desire in East Asian and Euro-Canadian Men

Differences in sexual desire between individuals of East Asian and European descent are well-documented, with East Asian individuals reporting lower sexual desire. The mechanisms that underlie this disparity have received little empirical attention. Recent research has found that sex guilt, “a generalized expectancy for self-mediated punishment for violating or for anticipating violating standards of proper sexual conduct” (Mosher & Cross, 1971, p. 27), mediates the relationship between culture and sexual desire in East Asian and Euro-Canadian women. The goal of this study was to explore this role of sex guilt in men. Male Euro-Canadian (n = 38) and East Asian (n = 45) university students completed online questionnaires. The East Asian men reported significantly lower sexual desire and significantly higher sex guilt. Sex guilt was a significant mediator of the relationship between ethnicity and sexual desire, as well as a significant mediator between mainstream acculturation and sexual desire. Among the East Asian men, mainstream acculturation was significantly and negatively correlated with sex guilt such that increasing mainstream acculturation was associated with less sex guilt. The diagnostic and clinical implications of the findings are discussed.
Improvement of demagnetization by rotor structure of IPMSM with Dy-free rare-earth magnet

Permanent magnet (PM) motors that employ rare-earth magnets containing dysprosium (Dy) are used in electric and hybrid electric vehicles. However, it is desirable to reduce the amount of Dy used since it is expensive. This study investigates the rotor structure of a PM synchronous motor with a Dy-free rare-earth magnet. Flux barrier shapes and PM thicknesses that enhance the irreversible demagnetization are investigated. In addition, a rotor structure that improves the irreversible demagnetization is proposed. We demonstrate that the proposed rotor structure without Dy improves the irreversible demagnetization.
A W-band 21.1 dBm power amplifier with an 8-way zero-degree combiner in 45 nm SOI CMOS

This paper presents a W-band power amplifier (PA) in 45 nm SOI CMOS. The PA incorporates an 8-way zero-degree combiner to efficiently combine 8 parallel PA units, each of which is a 2-stage cascode PA. At 80 GHz, the PA achieves a saturated output power (Psat) of 21.1 dBm, 10.1 dB peak gain, 5.2% peak PAE, and 12 GHz 3-dB bandwidth, and it consumes 1 mm2 of die area. The Psat of 21.1 dBm is the highest among reported W-band PAs in CMOS technology.
A QUADRATIC TYPE FUNCTIONAL EQUATION (DEDICATED IN OCCASION OF THE 70-YEARS OF PROFESSOR

In this paper, the solution and the Hyers–Ulam stability of the following quadratic type functional equation k ∑ i=2 ∑ "j∈{−1,1} f (x1 + "jxi) = 2(k − 1)f(x1) + 2 k ∑
Laser Scanner-based End-effector Tracking and Joint Variable Extraction for Heavy Machinery

A survey of mining accidents has revealed that over 30% of all truck loading accidents can be addressed by providing dipper positioning feedback to the shovel operator. In this paper, a novel approach is presented for estimating a mining shovel’s dipper pose to obtain its arm geometry in real-time utilizing a two-dimensional laser scanner. The low spatial resolution of laser scanners and the need for accurate initialization challenge the reliability and accuracy of most laser-scanner-based object tracking methods. This work addresses these issues by using the shovel dipper’s kinematics model and position history, in conjunction with the dipper geometrical model, to track the dipper in space. The proposed method uses a bootstrap particle filter with a distance transformation in order to perform a global search in the workspace. The particle filter’s result is then used as the initial pose for an Iterative Closest Point algorithm that increases the accuracy of the pose estimate. The proposed method can be applied to other laser scanner-based object tracking applications in outdoor environments. Experiments performed on a mining shovel demonstrate the reliability, accuracy, and computational efficiency of the proposed approach. Moreover, using a single proximal sensor can simplify mounting, reduce maintenance costs and machine down time, and enhance tracking reliability.
In vitro simultaneous measurement of refractive index and thickness of biological tissue by the low coherence interferometry

The authors proposed and demonstrated in vitro simultaneous measurement of refractive index and thickness of biological tissue. The technique is based on the low coherence interferometry combined with precise translation stages. Refractive indices were determined with the accuracy of less than 1% for tissue samples of a few hundred micron thickness, including chicken tissue, human tooth and nail. Simultaneous measurement of refractive index and thickness of multilayer tissue are also demonstrated.
EQUILIBRIUM AND KINETIC STUDY OF ADSORPTION OF NICKEL FROM AQUEOUS SOLUTION ONTO BAEL TREE LEAF POWDER

The ability of bael tree (BT) leaf powder to adsorb nickel, Ni, from aqueous solutions has been investigated through batch experiments. The Ni adsorption was found to be dependent on adsorbent dosage, initial concentration and contact time. All batch experiments were carried out at natural solution pH and at a constant temperature of 30°C using wrist-action shaker that operated at 120 rpm. The experimental isotherm data were analyzed using the Langmuir, Freundlich and Temkin equations. The monolayer adsorption capacity is 1.527 mg Ni per g BT leaf powder. The experiments showed that highest removal rate was 60.21% for Ni under optimal conditions. The kinetic processes of Ni adsorption on BT leaf powder were described by applying pseudo-firstorder and pseudo-second-order rate equations. The kinetic data for the adsorption process obeyed pseudo-second-order rate equations. The BT leaf powder investigated in this study exhibited a high potential for the removal of Ni from aqueous solution.
Kinetic simulation of a collisional shock wave in a plasma.

The ion kinetic structure of a planar collisional shock front in a fully ionized plasma is investigated using a new Vlasov-Fokker-Planck code. The effects of ionic viscosity and ionic thermal conduction are found to be much larger than assumed in usual hydrodynamic plasma simulations with classical transport coefficients. This might have consequences on the numerical modeling of inertial-confinement fusion targets.
1/f Noise Characterization in CMOS Transistors in 0.13μm Technology

Low-frequency noise has been studied on a set of n- and p-channel CMOS transistors fabricated in a 0. 13μm technology. Noise measurements have been performed on transistors with different gate lengths operating under wide bias conditions, ranging from weak to strong inversion. Noise origin has been identified for both type of devices, and the oxide trap density Nt, the Hooge parameter αH and the Coulomb scattering parameter αs have been extracted. The experimental results are compared with simulations using the BSIM3v3 MOS model.
Unobserved Heterogeneity in Panel Time Series Models

Recently, the large T panel literature has emphasized unobserved, time-varying heterogeneity that may stem from omitted common variables or global shocks that affect each individual unit differently. These latent common factors induce cross-section dependence and may lead to inconsistent regression coefficient estimates if they are correlated with the explanatory variables. Moreover, if the process underlying these factors is nonstationary, the individual regressions will be spurious but pooling or averaging across individual estimates still permits consistent estimation of a long-run coefficient. The need to tackle both error cross-section dependence and persistent autocorrelation is motivated by the evidence of their pervasiveness found in three well-known, international finance and macroeconomic examples. A range of estimators is surveyed and their finite-sample properties are examined by means of Monte Carlo experiments. These reveal that a mean group version of the common-correlated-effects estimator stands out as the most robust since it is the preferred choice in rather general (non) stationary settings where regressors and errors share common factors and their factor loadings are possibly dependent. Other approaches which perform reasonably well include the two-way fixed effects, demeaned mean group and between estimators but they are less efficient than the common-correlated-effects estimator.