Miracle-dz/UniFAR-FTUs huggingface dataset:
The Organized/Disorganized Typology of Serial Murder: Myth or Model?

Despite weaknesses in the organized/disorganizedclassification of serial killers, it is drawn on for “offender profiles,” theories of offending, and in murder trials. This dichotomy was therefore tested by the multidimensional scaling of the co-occurrence of 39 aspects of serial killings derived 100 murders committed by 100 U.S. serial killers. Results revealed no distinct subsets of offense characteristics reflecting the dichotomy. They showed a subset of organized features typical of most serial killings. Disorganized features are much rarer and do not form a distinct type. These results have implications for testing typologies supporting expert opinion or to help understand variations in criminal acts, as well as the development of a science of investigative psychology that goes beyond offender profiling. The organized/disorganized dichotomy is one of the most widely cited classifications of violent, serial offenders. Although first introduced by the special agents of the U.S. Federal Bureau of Investigation (FBI) Training Academy at Quantico in an examination of lust and sexual sadistic murders (Ressler, Burgess, Douglas, Hartman, & D’Agostino, 1986) the distinction has since been put forward to differentiate all sexual homicides and also types of arson in Douglas, Burgess, Burgess, and Ressler’s (1992) Crime Classification Manual. These authors have made the distinction between organized and disorganized offenders on criteria that they claim can be drawn from an examination of the crime scene, the victim, and forensic reports. Ressler et al. (1986) claimed that “. facets of the criminal’s personality are evident in his offense. Like a fingerprint, the crime scene can be used to aid in identifying the murderer” (p. 291). They proposed that offenders’ behavioral and personality characteristics can be determined from evidence at a crime scene (Ressler et al., 1986). This “fingerprint” is proposed to take one of two distinct forms, either organized or disorganized. The organized offender is described as leading an orderly life that is also reflected in the way he commits his crimes. Highlighting some proposed characteristics, he is claimed to be of average to high intelligence, socially competent, and more likely than the disorganized offender to have skilled employment. It is also claimed that he is apt to plan his offenses, use restraints on his victim, and to bring a weapon with him to commit the murder and to take the weapon away with him from the crime scene. In contrast, the crime scene of the disorganized
Consistency driven respiratory phase alignment and motion compensation in PET/CT

Respiratory motion in PET/CT imaging degrades PET image quantitation due to misaligned attenuation correction (AC) factors and motion blurring. This work explores the use of the Radon consistency conditions to compensate for these limitations in respiratory gated PET images in which only a single CT scan is available for AC. Specifically, we use the Radon consistency of AC-PET data as a metric to transform the attenuation map to match each phase of respiratory gated data, perform phase matched AC, and then use the inverse of the transformation parameters to align the gated PET images into a single phase. A final image volume is formed from summing PET images aligned to a single phase. We test this method with three transformation types applied to simulated data and measured patient PET/CT data. Results show successful alignment of attenuation maps and minor quantitative improvement with the proposed methods.
A comprehensive study on surface integrity of nickel-based superalloy Inconel 718 under robotic belt grinding

ABSTRACT Surface integrity of materials should be considered under robotic belt grinding in order to achieve desired finishing quality. In this work, the surface integrity of nickel-based superalloy Inconel 718, involving morphological structure, surface roughness, residual stress and structural domain size, was characterized systematically. A novel predicted model of grinding parameters optimization was proposed based on linear weighting function. The result shows that considerable compressive stress (about−355 MPa) and minimum roughness on material surface are achieved simultaneously at the grinding force of 178 kPa and belt speed of 31 m/s. The morphological structures and microhardness for the specimen under the optimized condition were further analyzed and discussed. Surface hardness is increased by 15%. Grain refinement and a large number of dislocations occur in the subsurface, which are attributed to continuous partial dynamic recrystallization associated with combined effects of plastic deformation and thermal treatment, which results from grinding force and belt speed. The new findings are of significance for ensuring surface integrity with optimal process parameters.
Measurement Properties of the Chinese Version of the Youth Quality of Life Instrument–Weight Module (YQOL-W)

Background Childhood obesity is a growing public health concern in China. It not only compromises physical health, but also has negative impacts on psychosocial well-being. As obesity rates increase, finding out what the perceptions of Chinese youth are regarding their weight is important for intervention planning and evaluation. However, there is a paucity of available obesity-specific instruments for children and adolescents in China and youth weight-specific quality of life (QOL) has been little reported. This study aimed to evaluate the measurement properties of the Chinese version of the Youth Quality of Life Instrument – Weight Module (YQOL-W). Methods The Chinese version of the YQOL-W was administered to 840 youth aged 11–18 from nine schools. Measurement properties including measurement model, reliability, validity and burden were evaluated. Results Confirmatory factor analysis showed that a three-factor model had acceptable model fit. The instrument had robust internal consistency reliability with Cronbach's α ranging from 0.84 to 0.96 and acceptable test-retest reliability with the intraclass correlation coefficients (ICCs) all higher than 0.7. The standard error of measurement (SEM) values for the Self, Social and Environment factors and total score were 10.352, 9.526, 12.086 and 8.425, respectively. The small real differences (SRDs) for the Self, Social and Environment factors and total score were 28.675, 26.387, 33.478, and 23.337, respectively. The Pearson's correlation coefficients between the YQOL-W and the PedsQL4.0 General Core Scales were stronger between comparable dimensions than those between less comparable dimensions, demonstrating convergent and discriminant evidence of construct validity. Significant differences were found in subscale and total scores across weight status, age and genders (P<0.01), supporting the known-groups validity of the instrument. Conclusion The Chinese version of the YQOL-W has acceptable measurement properties and can be used to assess the weight-specific QOL of children and adolescents in China.
Overexpression of PvPin1, a Bamboo Homolog of PIN1-Type Parvulin 1, Delays Flowering Time in Transgenic Arabidopsis and Rice

Because of the long and unpredictable flowering period in bamboo, the molecular mechanism of bamboo flowering is unclear. Recent study showed that Arabidopsis PIN1-type parvulin 1 (Pin1At) is an important floral activator and regulates floral transition by facilitating the cis/trans isomerization of the phosphorylated Ser/Thr residues preceding proline motifs in suppressor of overexpression of CO 1 (SOC1) and agamous-like 24 (AGL24). Whether bamboo has a Pin1 homolog and whether it works in bamboo flowering are still unknown. In this study, we cloned PvPin1, a homolog of Pin1At, from Phyllostachys violascens (Bambusoideae). Bioinformatics analysis showed that PvPin1 is closely related to Pin1-like proteins in monocots. PvPin1 was widely expressed in all tested bamboo tissues, with the highest expression in young leaf and lowest in floral bud. Moreover, PvPin1 expression was high in leaves before bamboo flowering then declined during flower development. Overexpression of PvPin1 significantly delayed flowering time by downregulating SOC1 and AGL24 expression in Arabidopsis under greenhouse conditions and conferred a significantly late flowering phenotype by upregulating OsMADS56 in rice under field conditions. PvPin1 showed subcellular localization in both the nucleus and cytolemma. The 1500-bp sequence of the PvPin1 promoter was cloned, and cis-acting element prediction showed that ABRE and TGACG-motif elements, which responded to abscisic acid (ABA) and methyl jasmonate (MeJA), respectively, were characteristic of P. violascens in comparison with Arabidopsis. On promoter activity analysis, exogenous ABA and MeJA could significantly inhibit PvPin1 expression. These findings suggested that PvPin1 may be a repressor in flowering, and its delay of flowering time could be regulated by ABA and MeJA in bamboo.
Voice Emotion Games: Language and Emotion in the Voice of Children with Autism Spectrum Conditio

Three decades of research have shown that children and adults with Autism Spectrum Conditions (ASC) may experience significant difficulties recognizing and expressing emotions and mental states. These difficulties are apparent when individuals with ASC attempt to recognize emotions from facial expressions, from vocal intonation, from gestures and body language. This ASC-Inclusion project set up advanced ICTenabled solutions and serious games that assist children with ASC to improve their socio-emotional communication skills, combining voice, face, and body gesture analysis, and giving corrective feedback regarding the appropriateness of the childs expressions. The present contribution focuses on the recognition of emotion in speech. For this purpose, a database of prompted phrases was collected in English, Swedish, and Hebrew, inducing nine emotions embedded in short-stories. It contains speech of children with ASC and typically developing children under the same conditions. We evaluate the emotion task over the nine categories, by investigating the discrimination of each emotion against the remaining ones. The results show performances up to 83.8 % unweighted average recall.
Intimate Partner Violence and Associated Coping Strategies among Women in a Primary Care Clinic in Port Harcourt, Nigeria

Context: Intimate partner violence (IPV) is an important gender-based, social, and public health problem, affecting women globally. Aims: The aim was to report the prevalence of IPV and describe the coping strategies of the victims. Settings and Design: It was conducted in the general outpatient clinic of a tertiary care hospital using a cross-sectional design. Materials and Methods: A random sample of consenting women living in an intimate partnership for a minimum of 1 year were served with a three part structured questionnaire which sought information on sociodemographic characteristics, the experience of IPV and the Brief COPE Inventory. Statistical Analysis Used: SPSS version 17.0 software, Microsoft word and Excel were used in data handling and analysis. Means, percentages, standard deviations, and Chi-square were calculated. P < 0.05 was considered to be significant. Results: Of the 384 participants, 161 (41.9%) were physically abused. IPV was significantly common among women ≤40 years of age, married couples (78.5%), unemployed and in Christians. It was precipitated by argument with husband (19.25%) and financial demands (44.10%). The employed coping strategy with the highest score was religion. The least score was found in substance abuse. Conclusion: There was significantly high prevalence of domestic violence against women in this study. Hence, routine screening is advocated by family physicians to elicit abuse in order to avoid the more devastating psychological consequences after the incidence so as to institute appropriate treatment as multiple episodes of abuse appears to be cumulative in effect. The reason for violence mainly borders around the argument with husband and finance issues. The coping strategies utilized by the participants minimally involve substance abuse, but more of a religion.
Neonatal estrogen exposure inhibits steroidogenesis in the developing rat ovary

Treatment of newborn female rats with estrogens significantly inhibits the growth and differentiation of the ovary. To understand the molecular mechanism of estrogen action in the induction of abnormal ovary, we examined the expression profiles of steroidogenic factor 1 (SF‐1) and several of its target genes in the developing ovaries after neonatal exposure to synthetic estrogen, estradiol benzoate (EB) by using reverse transcriptase polymerase chain reaction, in situ hybridization, and immunohistochemistry. Morphologic examination indicated inhibitory effects of estrogen on the stratification of follicles and development of theca and interstitial gland during postnatal ovarian differentiation. The expression of the steroidogenic acute regulatory protein (StAR) and cholesterol side‐chain cleavage cytochrome P450 (P450SCC), which are both essential for steroid biosynthesis, markedly decreased in theca and interstitial cells throughout the postnatal development of the EB‐treated ovary. However, expression of the transcriptional activator of the two genes, SF‐1 was unaffected in theca and interstitial cells, although the number of these cells was lower in the EB‐treated ovary than in the control ovary. The expression of the estrogen mediator, estrogen receptor‐α (ER‐α), diminished specifically in theca cells at P6 and recovered by P14 in the EB‐treated ovary. These results indicate that the effect of estrogens is mediated by means of ER‐α resulting in the down‐regulation of StAR and P450SCC genes during early postnatal development of the ovary. These results suggest that the abnormal ovarian development by neonatal estrogen treatment is closely correlated with the reduced steroidogenic activity, and the data obtained by using this animal model may account in part the mechanism for aberrant development and function of the ovary in prenatally estrogen‐exposed humans. © 2001 Wiley‐Liss, Inc.
Endothelial Cell Toxicity of Vancomycin Infusion Combined with Other Antibiotics

ABSTRACT French guidelines recommend central intravenous (i.v.) infusion for high concentrations of vancomycin, but peripheral intravenous (p.i.v.) infusion is often preferred in intensive care units. Vancomycin infusion has been implicated in cases of phlebitis, with endothelial toxicity depending on the drug concentration and the duration of the infusion. Vancomycin is frequently infused in combination with other i.v. antibiotics through the same administrative Y site, but the local toxicity of such combinations has been poorly evaluated. Such an assessment could improve vancomycin infusion procedures in hospitals. Human umbilical vein endothelial cells (HUVEC) were challenged with clinical doses of vancomycin over 24 h with or without other i.v. antibiotics. Cell death was measured with the alamarBlue test. We observed an excess cellular death rate without any synergistic effect but dependent on the numbers of combined infusions when vancomycin and erythromycin or gentamicin were infused through the same Y site. Incompatibility between vancomycin and piperacillin-tazobactam was not observed in our study, and rinsing the cells between the two antibiotic infusions did not reduce endothelial toxicity. No endothelial toxicity of imipenem-cilastatin was observed when combined with vancomycin. p.i.v. vancomycin infusion in combination with other medications requires new recommendations to prevent phlebitis, including limiting coinfusion on the same line, reducing the infusion rate, and choosing an intermittent infusion method. Further studies need to be carried out to explore other drug combinations in long-term vancomycin p.i.v. therapy so as to gain insight into the mechanisms of drug incompatibility under multidrug infusion conditions.
Translesion synthesis is the main component of SOS repair in bacteriophage lambda DNA

Agents that interfere with DNA replication in Escherichia coli induce physiological adaptations that increase the probability of survival after DNA damage and the frequency of mutants among the survivors (the SOS response). Such agents also increase the survival rate and mutation frequency of irradiated bacteriophage after infection of treated bacteria, a phenomenon known as Weigle reactivation. In UV-irradiated single-stranded DNA phage, Weigle reactivation is thought to occur via induced, error-prone replication through template lesions (translesion synthesis [P. Caillet-Fauquet, M: Defais, and M. Radman, J. Mol. Biol. 117:95-112, 1977]). Weigle reactivation occurs with higher efficiency in double-stranded DNA phages such as lambda, and we therefore asked if another process, recombination between partially replicated daughter molecules, plays a major role in this case. To distinguish between translesion synthesis and recombinational repair, we studied the early replication of UV-irradiated bacteriophage lambda in SOS-induced and uninduced bacteria. To avoid complications arising from excision of UV lesions, we used bacterial uvrA mutants, in which such excision does not occur. Our evidence suggests that translesion synthesis is the primary component of Weigle reactivation of lambda phage in the absence of excision repair. The greater efficiency in Weigle reactivation of double-stranded DNA phage could thus be attributed to some inducible excision repair unable to occur on single-stranded DNA. In addition, after irradiation, lambda phage replication seems to switch prematurely from the theta mode to the rolling circle mode.
Robotic gait training in patients with impaired consciousness due to severe traumatic brain injury

Primary objective: This prospective controlled non-randomized study investigated the effects of robotic gait training on electroencephalographic (EEG) brain activity in patients with impaired consciousness due to severe traumatic brain injury (TBI). Methods: Twelve TBI patients and 14 healthy controls underwent a single training session on a computer-driven gait orthosis (Lokomat®). The sensory pathways were assessed using sensory evoked potentials (SEPs). The global delta-alpha EEG power ratio (DAR) and latency of the P300 component of the event-related potentials was assessed prior to and following a training session. Results: Baseline measurements showed impaired SEPs in the majority of patients and significantly larger DAR in patients compared to healthy controls. Robotic gait training resulted in a reduction of the DAR in healthy subjects but not in patients. No changes were observed in P300 latencies after training in either patients or healthy controls. Conclusion: The study showed that robotic gait training induced measurable changes in the EEG power spectrum in healthy individuals, while no changes were observed in patients with severe TBI. The absence of the EEG changes following training might be an indicator of the severity of brain dysfunction.
Microbeam high-resolution x-ray diffraction in strained InGaAlAs-based multiple quantum well laser structures grown selectively on masked InP substrates

Structural and optical properties of the InGaAlAs-based multiple quantum well (MQW) 1. 3μm laser structures produced on InP (001) substrates by metal organic vapor phase epitaxy (MOVPE) technique in the regime of selective area growth (SAG) have been studied. An x-ray beam of 10μm diameter generated by a microbeam high-resolution x-ray diffraction (μ-HRXRD) setup based on an imaging one-bounce capillary optic and a three-bounce channel cut Si(004) analyzer crystal has been utilized to measure the diffraction curves from MQW structures grown between oxide mask stripes. The high angular resolution achieved in our experiments allowed accurate measurements of θ–2θ scans over a broad range of angles that was necessary for utilization of fitting algorithms for quantitative analysis of the strain and thickness of individual layers in the MQW structures. The thickness and strain variations in the quantum well and the barrier layers of the MQW SAG structure have been analyzed as a function of the oxide mask width i.
Effects of intravitreal injection of netrin-1 in retinal neovascularization of streptozotocin-induced diabetic rats

Background In a previous study, we confirmed that netrin-1 acts as an antiangiogenic factor by inhibiting alkali burn-induced corneal neovascularization in rats. Here, we continue working on the role of netrin-1 in retinal neovascularization. Methods Using an in vitro angiogenesis assay, we detected the effects of netrin-1 on human umbilical vein endothelial cell tube formation, viability and proliferation, migration, and invasion at concentrations of 0.1 μg/mL or 5 μg/mL. We intravitreally injected 0.1 μg/mL or 5 μg/mL netrin-1 into streptozotocin-induced rats to assess retinal neovascularization using retinal electrophysiology and electroretinography, enzyme-linked immunosorbent assay, fundus fluoresce in angiography, measurement of inner blood retinal barrier, retinal hematoxylin-eosin staining, and retinal flat-mount fluorescence assays. Results Human umbilical vein endothelial cell tube formation, viability and proliferation, migration, and invasion were upregulated by netrin-1 at a concentration of 0.1 μg/mL (P<0.05), while 5 μg/mL netrin-1 had an opposite effect (P<0.05) in our in vitro angiogenesis assay. Retinal electrophysiology testing revealed that intravitreal injection of netrin-1 affected the amplitude of a- and b-waves (a-wave: 0.1 μg/mL netrin-1 =17.67±3.39 μm, 5 μg/mL netrin-1 =28.50±1.31 μm, phosphate-buffered saline [PBS]-treated =17.67±3.39 μm; b-wave: 0.1 μg/mL netrin-1 =44.67±4.80 μm, 5 μg/mL netrin-1 =97.17±9.63 μm, PBS-treated =44.67±4.80 μm) and the expression of VEGF-A (no-treatment rats, 9.29±0.80 pg/mL; PBS-treated rats, 19.64±3.77 pg/mL; 0.1 μg/mL netrin-1 treated rats, 21.37±3.64 pg/mL; 5 μg/mL netrin-1 treated rats, 9.85±0.54 pg/mL, at 6 weeks after induction). By comparing fluoresce in angiography, level of inner blood retinal barrier breakdown (% of control), retinal hematoxylin-eosin staining, and collagen-IV fluorescence assays in the retinas of PBS-treated rats, netrin-1 was found to suppress and reverse retinal neovascularization at a concentration of 5 μg/mL (P<0.05), while 0.1 μg/mL netrin-1 (P<0.05) led to an increase in the number of new retinal blood vessels, after 6 weeks’ injection. Conclusion Netrin-1 could play a significant role in retinal neovascularization by dual-direction regulating angiogenesis dependent on dosage.