Miracle-dz/UniFAR-FTUs huggingface dataset:
Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain

Glial cells are essential for the development and function of the nervous system. In the mammalian brain, vast numbers of glia of several different functional types are generated during late embryonic and early foetal development. However, the molecular cues that instruct gliogenesis and determine glial cell type are poorly understood. During post-embryonic development, the number of glia in the Drosophila larval brain increases dramatically, potentially providing a powerful model for understanding gliogenesis. Using glial-specific clonal analysis we find that perineural glia and cortex glia proliferate extensively through symmetric cell division in the post-embryonic brain. Using pan-glial inhibition and loss-of-function clonal analysis we find that Insulin-like receptor (InR)/Target of rapamycin (TOR) signalling is required for the proliferation of perineural glia. Fibroblast growth factor (FGF) signalling is also required for perineural glia proliferation and acts synergistically with the InR/TOR pathway. Cortex glia require InR in part, but not downstream components of the TOR pathway, for proliferation. Moreover, cortex glia absolutely require FGF signalling, such that inhibition of the FGF pathway almost completely blocks the generation of cortex glia. Neuronal expression of the FGF receptor ligand Pyramus is also required for the generation of cortex glia, suggesting a mechanism whereby neuronal FGF expression coordinates neurogenesis and cortex gliogenesis. In summary, we have identified two major pathways that control perineural and cortex gliogenesis in the post-embryonic brain and have shown that the molecular circuitry required is lineage specific.
Glutathione homeostasis in ventricular myocytes from rat hearts with chronic myocardial infarction

The ubiquitous tripeptide glutathione (GSH) is an essential factor in many biological processes, thus its depletion has a major impact on cell function and survival. In this study, we examined regulation of GSH in cardiomyocytes under chronic oxidative stress elicited by myocardial infarction (MI). Cardiac dysfunction was induced in rats by coronary artery ligation, and experiments were conducted in myocytes isolated from non‐infarcted left ventricle and septum after 6–8 weeks. Fluorescence microscopy studies using the probe monochlorobimane showed that [GSH] in myocytes from post‐MI hearts was 42% less than in sham control hearts (P < 0.05). However, depleted GSH levels were normalized after 5–6 h by an insulin mimetic (bis‐peroxovanadium‐1,10‐phenanthroline, bpV(phen); 10 μmol l−1) or by exogenous pyruvate (5 mmol l−1). The increase in [GSH] by bpV(phen) was partly inhibited by buthionine sulphoximine (BSO; 50 μmol l−1), a blocker of GSH synthesis, and by 1,3‐bis‐(2‐chloroethyl)‐1‐nitrosourea (BCNU; 100 μmol l−1), an inhibitor of glutathione disulphide reductase. By comparison, the effect of pyruvate was not altered by BSO but was completely blocked by BCNU. Studies using inhibitors of signalling cascades indicated that upregulation of [GSH] by bpV(phen) in myocytes from post‐MI hearts was mediated by mitogen activated protein kinase/extracellular signal‐regulated kinase kinase 1/2 and p38 mitogen‐activated protein kinase but not by phosphatidylinositol 3‐kinase. The effect of pyruvate was not altered by any kinase inhibitor tested. In cells loaded with the probe TEMPO‐9‐AC to monitor superoxide anion, baseline fluorescence was 2.3‐fold greater in post‐MI myocytes than in sham control myocytes (P < 0.05) and was markedly decreased by diphenyleneiodonium (30 μmol l−1), an inhibitor of NADPH oxidase, exogenous GSH (10 mmol l−1) or bpV(phen). In parallel studies, [GSH] in post‐MI myocytes was also normalized by diphenyleneiodonium or exogenous GSH. These data show that GSH is differentially regulated by receptor tyrosine kinase‐dependent and ‐independent agonists that maintain functional GSH levels necessary to neutralize excess generation of reactive oxygen species in the failing heart.
A Reinterpretation of the Keynesian Consumption Function and Multiplier Effect

We propose a microeconomic foundation of the multiplier effect and that of the consumption function using a dynamic optimization model that explains a shortage of aggregate demand and unemployment. We show that government purchases boost aggregate demand through a multiplier-like process but that the implication is quite different. It works through not an increase in disposable income but moderation of deflation, which makes money holding costly and stimulates consumption.
Marked Disturbance of Calcium Homeostasis in Mice With Targeted Disruption of the Trpv6 Calcium Channel Gene

We report the phenotype of mice with targeted disruption of the Trpv6 (Trpv6 KO) epithelial calcium channel. The mice exhibit disordered Ca2+ homeostasis, including defective intestinal Ca2+ absorption, increased urinary Ca2+ excretion, decreased BMD, deficient weight gain, and reduced fertility. Although our Trpv6 KO affects the closely adjacent EphB6 gene, the phenotype reported here is not related to EphB6 dysfunction.
The Modified Cormack-Lehane Score for the Grading of Direct Laryngoscopy: Evaluation in the Asian Population

The use of a modified Cormack-Lehane scoring system (MCLS) of laryngoscopic views, as previously introduced in the Western population, was investigated during direct laryngoscopy in the Asian population. We studied the distribution of the different grades of MCLS, the predictive factors and rate of difficult laryngoscopy, and the association with difficult intubation. Six hundred and five patients requiring tracheal intubation during general anaesthesia were prospectively studied. The optimal views during direct laryngoscopy were scored using the 5-grade MCLS system. The distribution of the laryngoscopy scores was 73.9% Grade 1 (full view of the vocal cords), 21.0% Grade 2A (partial view of the vocal cords), 3.3% Grade 2B (only the arytenoids and epiglottis seen), 1.6% Grade 3 (only epiglottis visible) and 0.2% Grade 4 (neither the epiglottis nor glottis seen). External laryngeal pressure was necessary in 45.3% of cases to optimize laryngoscopic views. Grade 2B was associated with significantly higher incidence of difficult intubation compared with Grade 2A (65% vs 13.4%). The rates of difficult laryngoscopy and intubation were 5.1% and 6.9% respectively. The Mallampati classification and thyromental distance were associated with low predictive value for difficult laryngoscopy. The MCLS better delineates the difficulty experienced during laryngoscopy than the original Cormack-Lehane grading.
Sport Type Classification of Mobile Videos

The recent proliferation of mobile video content has emphasized the need for applications such as automatic organization and automatic editing of videos. These applications could greatly benefit from domain knowledge about the content. However, extracting semantic information from mobile videos is a challenging task, due to their unconstrained nature. We extract domain knowledge about sport events recorded by multiple users, by classifying the sport type into soccer, American football, basketball, tennis, ice-hockey, or volleyball. We adopt a multi-user and multimodal approach, where each user simultaneously captures audio-visual content and auxiliary sensor data (from magnetometers and accelerometers). Firstly, each modality is separately analyzed; then, analysis results are fused for obtaining the sport type. The auxiliary sensor data is used for extracting more discriminative spatio-temporal visual features and efficient camera motion features. The contribution of each modality to the fusion process is adapted according to the quality of the input data. We performed extensive experiments on data collected at public sport events, showing the merits of using different combinations of modalities and fusion methods. The results indicate that analyzing multimodal and multi-user data, coupled with adaptive fusion, improves classification accuracies in most tested cases, up to 95.45%.
Facial bone alterations on maxillary anterior single implants for immediate placement and provisionalization following tooth extraction: a superimposed cone beam computed tomography study.

OBJECTIVES The purpose of this cone beam computed tomography (CBCT) study was to describe the facial bone changes around single implants for immediate placement and provisionalization following tooth extraction in the maxillary anterior. MATERIAL AND METHODS The data between 2008 and 2013 were collected retrospectively. Superimposed facio-palatal cross-sectional CBCT images for the implants were derived from preoperative and postoperative radiographs via standardized CBCT processes. Horizontal and vertical facial measurements on the implants were identified at preoperative and approximately 1-year postoperative follow-ups. Correlation coefficient for those parameters was evaluated. RESULTS A total of 12 single implants in 12 patients were included in this study. The mean loading period was 13.3 months (range 12-15 months). The median data of preoperative bone thickness 0.54 mm (A), preoperative vertical bone level 1.46 mm (B), postoperative bone thickness 1.77 mm (C), postoperative vertical bone level 1.08 mm (D), horizontal distance from outer surface of preoperative facial bone to implant surface 2.08 mm (E), horizontal gap distance 1.41 mm (E-A), horizontal bone resorption -0.26 mm (E-C), and vertical bone resorption -0.25 mm (B-D) were obtained. The data at the implant platform level (IPL) were selected for the horizontal measurements. Spearman's analysis demonstrated statistically significant correlations between B and D, C and E, E and E-A, and B and E-C (P < 0.01). Significant correlations between C and B, D, and E-A were also found, respectively (P < 0.05). CONCLUSIONS Immediate placement and provisionalization of single implants procedure in the maxillary anterior showed excellent outcomes with the small facial bone alterations around the implants. Neither preoperative facial bone thickness nor horizontal gap distance influenced the amount of facial bone resorptions.
Offspring at high and low risk for depression and anxiety: mechanisms of psychiatric disorder.

OBJECTIVES To examine the effect of parental psychiatric diagnosis on the risk of psychiatric disorder in their offspring and to determine mediators and independent predictors of psychiatric disorder in offspring. METHOD The sample consisted of 145 offspring (between the ages of 6 and 24 years, who were directly interviewed) of probands with early-onset (before age 30 years) major depressive disorder (MDD) without panic, panic disorder with and without major depression, and a normal, never psychiatrically ill control group who were part of a large study conducted to determine the relationship between panic disorder and major depression. RESULTS The risk for offspring MDD was increased by proband recurrent early-onset MDD and coparent alcohol abuse. Chaotic family environment was the only independent predictor of dysthymia. The risk for offspring "any anxiety" disorder was increased by proband recurrent early-onset MDD and coparent impaired functioning. The association between MDD in proband and "panic spectrum" disorder in offspring was accounted for by chaotic family environment. CONCLUSION Recurrent parental MDD has consistently been shown to be a strong risk factor for offspring MDD. Family environment plays an important role in low-level anxiety symptoms and dysthymia. Clinicians treating adults should be alert to risk factors for their offspring and to appropriate targets for early intervention.
Rapid prototyping of scaphoid and lunate bones

In this study, a novel rapid prototyping technology was used to fabricate scaphoid and lunate bone prostheses, two carpal bones that are prone to avascular necrosis. Carpal prostheses were fabricated with an Envisiontec Perfactory® SXGA stereolithography system using Envisiontec eShell 200 photocurable polymer. Fabrication was guided using 3‐D models, which were generated using Mimics software (Materialise NV, Leuven, Belgium) from patient computer tomography data. The prostheses were fabricated in a layer‐by‐layer manner; ∼ 50‐μm thick layers were observed in the prostheses. Hardness and Young's modulus values of polymerized eShell 200 material were 93.8 ± 7.25 MPa and 3050 ± 90 MPa, respectively. The minimum compressive force required for fracture was 1360 N for the scaphoid prosthesis and 1248 N for the lunate prosthesis. Polymerized Envisiontec eShell material exhibited high human neonatal epidermal keratinocyte cell viability rate in an MTT assay. The results of this study indicate that small bone prostheses fabricated by stereolithography using eShell 200 polymer may have suitable geometry, mechanical properties, and cytocompatibility properties for in vivo use.
Reliable disjoint path set selection in mobile Ad-hoc Networks using Noisy Hopfield Neural Network

Mobile Ad-hoc NETwork (MANET) is a collection of wireless mobile nodes without any fixed base-station infrastructure and centralized management. Topological changes in MANETs render routing paths unusable. The multipath routing addresses this problem by providing more than one route to a destination node. Shared links and nodes between paths present common failure points which can disable many or all of the paths. Disjoint path set requires the multiple paths to be link-or node-disjoint. However, selecting an optimal path set is an NP-complete problem. Neural networks have been proposed as computational tools for solving constrained optimization problems. A Noisy Hopfield Neural Network (NHNN) is proposed as a path set selection algorithm in this paper. This algorithm can find either node-disjoint or link-disjoint path set with no extra overhead. This approach is beneficial for mobile ad-hoc networks, since it produces a set of backup paths with high reliability.
Hyperfiltration affects accuracy of creatinine eGFR measurement.

BACKGROUND AND OBJECTIVES Surrogate markers such as creatinine, cystatin C (CysC), and beta trace protein (BTP) have been used to estimate GFR (eGFR). The accuracy of eGFR may be altered with hyperfiltration and differences in filtration fraction (FF). It is hypothesized that the accuracy of creatinine for eGFR may be affected by hyperfiltration and different effective renal plasma flow (ERPF). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS A total of 127 pediatric patients with various renal diseases underwent simultaneous measurements of GFR using 51Cr-EDTA renal scan and ERPF (131I-hippurate clearance) to calculate the FF (FF=GFR/ERPF). The eGFRs were calculated using the commonly used Schwartz (creatinine), Filler (CysC), and Benlamri (BTP) formulas. Agreement of the eGFRs with the measured isotope GFRs was assessed by Bland-Altman plots. Correlation analysis was performed using nonparametric tests to compare FF with eGFR-GFR. RESULTS The 127 children at a median age (with 25th percentile, 75th percentile) of 11.9 (8.5, 14.9) years had a mean 51Cr EDTA-GFR of 100.6±32.1 ml/min per 1.73 m2 and a median 131I-hippurate clearance (ERPF) of 588 (398,739) ml/min per 1.73 m2. Mean FF was 17.7±4.5% with no correlation between the FF and the error (eGFR-GFR) for CysC and BTP eGFR, whereas there was a significant negative correlation between the error for Schwartz eGFR and FF. CONCLUSIONS There is a significant negative correlation between the error for the Schwartz eGFR and the FF. CysC and BTP are not affected by differences in FF.
Unnecessary Removal of Central Venous Catheters in Cancer Patients with Bloodstream Infections

We evaluated the rate of central venous catheter (CVC) removal in 283 cancer patients with bloodstream infections (BSIs). Removal of CVCs occurred unnecessarily in 57% of patients with non-central-line-associated BSI (non-CLABSI), which was equivalent to the rate of CVC removal in patients with CLABSIs. Physician education and safe interventions to salvage the vascular access are warranted. Infect Control Hosp Epidemiol 2018;39:222–225
Torque Ripple Reduction of Predictive Torque Control for PMSM Drives With Parameter Mismatch

Predictive torque control (PTC) is based on the prediction of motor torque and stator flux for all possible voltage vectors of power converter. These predictions are derived from a mathematical model of the motor that depends on the motor parameters. But, these parameters may not match with their actual values. These parametric uncertainties lead to inaccurate predictions of torque and stator flux and affect the performance of the predictive algorithm. This paper presents a modified PTC for a permanent magnet synchronous motor to reduce the torque ripple at the presence of parametric uncertainty by improving the prediction accurateness. Simulation and experimental results are provided to show the effect of the proposed method.
An investigation into the effectiveness of ELF protective clothing when exposed to RF fields between 65 MHz and 3 GHz

Protective garments are worn by electric power workers to shield the body against electromagnetic fields. This paper uses the finite-difference time-domain method to calculate SAR in the heterogeneous human voxel model NORMAN, clad in a protective suit and exposed to radio-frequency (RF) electromagnetic fields between 65 MHz and 3 GHz. The representation of the suit was produced for this work by the modelling and voxelization of a surface-rendered object, based on the dimensions of the male voxel phantom. The calculations showed that the peak-localized SAR in the head was higher than that calculated for a model without a protective suit for a number of exposure situations. These localized SAR values could be up to three times the values of those calculated for a model without a protective suit for a particular frequency. It is thought that the SAR hotspots in the head are caused by resonances in a cavity, which in this case is the conductive hood of the suit. This work shows that the increase in the peak-localized SAR in the head due to wearing the suit meant that, in certain situations, the ICNIRP and IEEE reference levels were no longer conservative. Therefore, it is important that power line workers exposed to RF fields wear the correct high-frequency protective suits with conducting visors.
Comparison of evoked potentials and high-frequency (gamma-band) oscillating potentials in rat auditory cortex.

1. Transient and steady-state (40 Hz) evoked potentials, as well as spontaneous and click-evoked gamma-band oscillations, were recorded from 15 lightly anesthetized rats using an 8 x 8 electrode epipial array covering auditory cortex and adjacent areas to determine and compare the spatiotemporal distributions of these four phenomena. 2. The transient evoked response replicated earlier findings in our laboratory, consisting of an initial biphasic sharp wave in area 41, a similar but delayed biphasic sharp wave in area 36, and more widely distributed slow-wave components. Spatiotemporal analysis supported a model of parallel and asynchronous activation of distinct groups of thalamocortical projections underlying the neurogenesis of these temporal components of the middle-latency auditory evoked potential (MAEP) complex. 3. The 40-Hz response to click trains was superimposed on a steady potential shift (SP), both of which were localized within primary auditory cortex. Epipial distributions of the SP were similar to those of the shortest-latency negative peak in area 41 recorded in the same animals, suggesting similar neural generators. The 40-Hz response was more focal and dissimilar from the SP and any other temporal components of the MAEP complex, suggesting that a unique subpopulation of cells underlies its neurogenesis. 4. Spontaneous gamma-band activity, as assessed by power spectrum analysis, was localized to primary and secondary auditory cortex but had a variable distribution between rats that did not conform to the cytoarchitectonic boundaries within subdivisions of this region. Digital movies computed for individual bursts of gamma-activity indicated a high degree of spatiotemporal variability within and between bursts. 5. Single-trial spectral analysis of click responses indicated an inhibition of gamma-band oscillations during most of the MAEP complex, with subsequent enhanced gamma-activity during the 300- to 350-ms slow-wave component that outlasted the MAEP by approximately 500 ms. The epipial distributions of prestimulus and enhanced poststimulus gamma-oscillations were the same. In contrast to the 40-Hz response to click trains, phase-locking of gamma-oscillations by the single click stimulus was not observed. 6. These results suggest that both the MAEP complex and the steady-state 40-Hz response with its associated SP are highly stereotyped in lightly anesthetized rodent cortex. Their spatiotemporal distributions are probably determined in large part by asynchronous activation of parallel thalamocortical projection systems. Our data suggest no direct link between either the MAEP or the steady-state 40-Hz response to spontaneous or evoked gamma-band oscillations in auditory cortex. (ABSTRACT TRUNCATED AT 400 WORDS)
Oral health knowledge, behaviour and practices among school children in Qatar

Background: The aim of this study was to assess the oral health knowledge behaviour and practices among school children in Qatar. Materials and Methods: A cross-sectional study was carried out in Qatar from October 2011 to April 2012. A total of 2200 school children aged 12–14 years were approached from 16 schools of different areas. The information about oral health knowledge and sources of information was obtained through a self-administrated questionnaire. Data analyses were performed. Results: The overall response rate was (96%). Only (25.8%) of children reported a high level of oral health knowledge. After each meal, tooth brushing was observed by a very low percentage of children (3.7%). About 44.6% of children recognized dental floss as a cleaning device for between the teeth. A large number of children (32.5%) thought incorrectly that one must visit the dentist only in case of pain. A great majority was not aware of cariogenic potential of soft drinks (39%) and sweetened milk (97.8%). Less than half (38.9%) of children actually had heard about fluoride. Only (16.8%) correctly answered the question about sign of tooth decay. Slightly, less than half (48.4%) could not define the meaning of plaque. Parents were the most popular (69.1%), source of oral health information for the children. Conclusion: The oral health knowledge in Qatar is below the satisfactory level. Parents were the most popular source of oral health knowledge for the children followed by dentists, school teachers, and media.