Miracle-dz/UniFAR-FTUs huggingface dataset:
Diazepam binding inhibitor fragment 33–50 (octadecaneuropeptide) immunoreactivity in the cerebellar cortex is restricted to glial cells

The distribution of octadecaneuropeptide (ODN)‐like immunoreactivity (LI) and its relationship to γ‐aminobutyric acid (GABA)‐LI were investigated in the cerebellar cortex of adult rats with electron microscopy. At the electron microscopic level, ODN‐LI was found exclusively in glial cells. In addition to Bergmann glia and its processes, cerebellar astrocytes were also labelled, encapsulating unlabelled neuronal elements of the cerebellum. These ODN‐LI glial processes were observed in close apposition to synaptic junctions, but immunoreactivity could not be found in the synaptic cleft or in association with neuronal membranes. Since GABA‐LI is always associated with neuronal elements, the colocalization of GABA‐ and ODN‐LI could not be confirmed in the cerebellar cortex. Our results do not support the assumption that ODN is a neuron‐specific processing product of diazepam binding inhibitor. © 1994 Wiley‐Liss, Inc.
Roles of Fun and Flow in Social Media Usage - A Comparative Study of American and Chinese Students

This study investigates what social and psychological factors are driving social media usage. The study focuses on hedonic and utilitarian behavior with constructs from games and psychology, the Technology Acceptance Model (TAM), and shopping behavior that are then used to develop a revised model of TAM. The empirical study was conducted in the US and China among college students. Three different models are constructed and the composite model has a high r-square. A comparative analysis is conducted as to the extent to which these constructs play roles in the two populations. The results indicate that in general US students enjoy a greater sense of flow and fun while using social media and have a stronger intention to use it in the future.
Endocrine prevention of chemotherapy-induced ovarian failure

Purpose of review Fertility preservation has recently gained a worldwide interest among fertility specialists, oncologists, and all healthcare providers. Thus, the protection against iatrogenic infertility caused by chemotherapy assumes a high priority. Specifically, the issue of endocrine prevention of gonadotoxicity is still a controversial subject. Recent findings During the last year, many publications on this subject appeared, swinging the pendulum toward the beneficial role of gonadotropin-releasing hormone agonist (GnRHa) cotreatment for fertility preservation despite gonadotoxic chemotherapy. Here, we summarize the recent publications on fertility preservation and minimizing chemotherapy-induced gonadotoxicity. Summary More than 10 recent meta-analyses have concluded that GnRHa is beneficial and may decrease the risk of premature ovarian failure and increase the pregnancy rate in survivors. Furthermore, two recent international meetings of experts have concluded that GnRHa is effective and should be offered to every young woman facing gonadotoxic chemotherapy.
Accounting for Derivatives with Initial Margin Under IFRS 13

Initial margin is required by central counterparties (CCPs) and under regulatory Bilateral Initial Margin (BCBS-317). This initial margin is contractually defined in Clearing Arrangements (CA) or Collateral Support Deeds (CSD) respectively. We investigate whether the cost of this initial margin over the life of the affected trades (known as Margin Valuation Adjustment, MVA) should be accounted for in Accounting Fair Value under IFRS 13. We find strong indications that MVA should be reflected in Fair Value given that to exit the affected trades any financial institution taking them over would face the same costs from the trades and additional required contracts (CA or CSD) that the first financial institution already faced. In addition the CA/CSD that give rise to MVA are contractually connected to the related trades and contribute to the overall project costs of the trades. These CA/CSD project costs are analogous to costs from cashflows due to Collateral Support Agreements (CSAs) which have a similar contractual relation to trades and CSAs are routinely included in trade pricing. Whether MVA is reported separately or as part of desk activity depends on the applicable unit of account given the internal setup of the financial institution and specific trading patterns following IFRS 9 and IFRS 13.
Reconstruction of the left thumb with a second toe transfer in a musician's hand

Abstract The free microvascular transfer of toes for reconstruction of the thumb remains to be an area of interest in microsurgery. The goal of reconstruction is to restore the prehensile abilities of the thumb, while achieving acceptable appearance and minimizing morbidity at the donor site. We report the case of a 21-year-old man who had second toe-to-thumb reconstruction after post-traumatic amputation of his left thumb at the metacarpophalangeal level. Before the accident, he played a musical string instrument, the “Saz”, regularly. The traditional method of playing the Saz is to pluck the strings with the fingers of the right hand and pick the strings with the thumb and fingers of the left hand. Three months after the operation, he was playing the saz again, proving that he had sufficient strength in opposition, adduction, and flexion force in the transferred toe.
14th International HLA and Immunogenetics Workshop: report on mapping microsatellite markers in the major histocompatibility complex region.

This paper describes the use of the program e-pcr to localize 687 known major histocompatability complex (MHC) microsatellite primer pairs to their sequence positions in several genomic assemblies across the MHC region. The sequences used were the Sequences of Sanger Institute's MHC Haplotype Project: COX, PGF, QBL, as well as the Celera, and Reference (PGF across extended MHC) sequences from the NCBI genomic build 36. More than 95% (664/687) of the markers mapped unambiguously to the Reference assembly sequence. All primer pairs used in this analysis, and those were previously unknown to UniSTS, have now been assigned permanent public UniSTS identifiers. Mapping and descriptive data for each primer pair are available at the publicly accessible dbMHC microsatellite resource: http://www.ncbi. nlm.nih. gov/projects/mhc/xslcgi.fcgi? cmd=mssearch.
The Role of Restrictiveness of Use in Determining Ethical and Legal Awareness of Unauthorized File Sharing

A host of different types of information goods are available for free download from illegal file sharing sites. As far as price is concerned, no company can compete against “free. ” Hence, managers, researchers, and policy makers are interested in determining factors other than price that might influence consumers’ file sharing behavior. Moral consideration is one factor that might sway individuals to pay for files they could otherwise obtain for free. To help better understand how moral consideration works in the context of file sharing, this research examines how people form perceptions of the legality and ethicalness of downloading music files through file sharing. We propose that when people receive files in a more restrictive manner (e.g. streaming vs. downloading) they are less likely to recognize file sharing as being unethical or illegal. We conduct five studies to test our theory of restrictiveness. The results consistently indicate that consumers’ perceptions of legality and ethicalness of file sharing are associated with restrictiveness of use. In particular, while file sharing with different levels of restrictiveness still transfers intellectual property from one individual to another, increased restrictiveness results in consumers being less likely to identify file sharing as being illegal or unethical. This in turn has a great impact on their actual engagement in the unauthorized file sharing activities. We find the relationships are significant even when controlling for several other elements such as gender, age, income, and prior knowledge about how and where to go on the internet to participate in file sharing.
Sovereign Reputation and Yield Spreads: A Case Study on Retroactive Legislation

Abstract This paper uses recent legislation in Austria to establish a link between sovereign reputation and yield spreads. In 2009, Hypo Alpe Adria International, a bank previously co-owned by the regional government of Carinthia, had been nationalized by Austria’s central government in order to avoid a default triggering multi-billion Euro local government guarantees. In 2015, special legislation retroactively introduced collective action clauses allowing a haircut on both the bonds and the guarantees while avoiding formal default. We document that legislative and administrative action designed to partly abrogate the guarantees resulted in a loss of reputation, leading to higher yield spreads for sovereign debt. Our analysis of covered bonds uncovers an increase in yield spreads on the secondary market and a deterioration of primary market conditions.
SUBSTANTIATING PUBLIC RELATIONS CONTRIBUTIONS TO ORGANIZATIONAL SUCCESS IN NIGERIA'S BANKING SECTOR

This paper attempts to substantiate the contributions of public relations in Nigeria's banking sector. This is against the backdrop of a seeming neglect for the profession. In gathering data for the work, the survey method was complemented with in-depth interviews. The study found that banks generate a public relations philosophy, that public relations makes important contribution to the success of the banking sector and also that a good reputation positively affects an organization's (including banks) positive performance. It is therefore recommended among others that banks in Nigeria should elevate the status of their PR departments and better appreciate them while the PR executives should have a multi- disciplinary training that makes them competent in business administration and others.
Neoadjuvant chemotherapy as ovarian cancer treatment: ever more used with major regional differences.

INTRODUCTION The traditional first-line treatment for patients with advanced ovarian cancer with primary debulking surgery (PDS) and adjuvant chemotherapy is controversial as some authors report a potential benefit from the alternative treatment with neoadjuvant chemotherapy (NACT) and interval debulking surgery. The aim of this study was to investigate the use of NACT in Denmark in regard to increased use and regional differences. MATERIAL AND METHODS Stage IIIC and IV ovarian cancer patients treated in the five Danish tertiary referral centres in the 2005-2010-period were included. The study is based on validated data from The Danish Gynaecological Cancer Database. RESULTS Of the 1,367 eligible patients 1,069 were treated with PDS and 298 with NACT. In 2005-2007, 11% of patients were treated with NACT. In 2008-2010, this percentage had risen to 30% (p < 0.00001). Between the five referral centres, the use of NACT ranged from 6% to 41% in 2005-2010 (p < 0.00001); from 1 % to 31% in 2005-2007 (p < 0.00001); from 10% to 48% in 2008-2010 (p < 0.00001) and from 9% to 48% in 2010 (p < 0.0008). Patients treated with NACT were significantly older, had inferior ASA scores and Eastern Cooperative Oncology Group performance status compared with the patients from the PDS group. There was no difference between treatments in regard to body mass index, stage IV disease or patients with no co-morbidity. CONCLUSION The use of NACT as first-line treatment tripled from 2005-2010, but the regional variability was large which calls for a uniform agreement on treatment principles and evaluation. FUNDING This study was financially supported by grants from The Copenhagen University Hospital Research Foundation, Manufacturer Einar Willumsens Memorial Trust, The Capital Region of Denmark Research Foundation, The Arvid Nilsson Foundation, The King Christian X Foundation, The Dagmar Marshall Foundation, The Danish Research Foundation, and The Hans and Nora Buchard Foundation. TRIAL REGISTRATION not relevant.
Do labels influence purchase decisions of food products? Study of young consumers of an emerging market

Purpose The purpose of this paper is to study the usage and influence of food labels by the young consumers of an emerging market where food labeling regulation is comparatively recent phenomenon. Design/methodology/approach A purposely developed questionnaire was administered to 300 randomly selected youths of age between 18 and 30 years. The first part of the questionnaire sought information on socio-demographic profile, whereas the second part of the questionnaire had questions related to consumers’ perception of importance, their reading behavior, and their responses on the information content of food labels. Appropriate statistical tools were used to analyze the data. Findings Results revealed that young Indian consumers attached considerable importance to the food labels and read it before making a final purchase decision. In addition to price, all the product attributes which had implications for the consumers’ health were considered as extremely important by the young consumers. Information regarding different important product attributes can be broadly clubbed in two categories, namely, “product specification” and “product quality. ” The final decision to purchase a product based on the food labels varied significantly based on the consumers’ gender, age, food habit, and residential locality. Research limitations/implications Nature of study does not allow drawing a conclusion regarding the causal relationship between food labels and consumers’ purchase decisions. Originality/value As labeling regulation is a comparatively recent phenomenon in India, study of the usage and influence of food labels on young consumers’ purchase decision, a hitherto not much-studied subject, will contribute significantly to the literature on food labels.
Valuation of Business in Virtual Reality

Recent years brought fast growth and fall of popularity of virtual worlds and virtual ventures. Many companies moved their activity to the virtual reality. Virtual worlds strongly increased their communities. Researches show that they influence on the real world activity. Selected problems related to valuation and defining of economic activity in virtual reality were described. Author has developed a model of business valuation in virtual reality, based on the Customer Lifetime Value method.
The Relation between Sustainable Innovation Strategy and Financial Performance Mediated By Environmental Performance

This study aims to examine the relationship of sustainable innovation strategy and financial performance through the mediation environmental performance. The hypothesis in this study is sustainable innovation strategy affect the financial performance which is mediated by environmental performance. This study is quantitative research in the explanatory level. The population of this study is all the manufacturer companies in East Java. The data is collected through questionnaire. The unit of analysis is a business unit. The respondent of this study is the manager of a business unit manufacturing company in East Java. The results showed that the environmental performance mediates partially the relation between sustainable innovation strategy and financial performance.
Topology-Based Controllability Problem in Network Systems

In network systems with a huge number of nodes, it is not possible to apply input signals to all network nodes to control them. In this paper, we show that this issue can be addressed by designing a network topology so that the nodes in the network system are controllable by a few nodes in the system. A theoretical framework that provides the basic link between structural controllability of network systems and the topology design problem is developed. The results also shed light on how new nodes can be added to the network system without having to introduce new control nodes. Hence, the results are useful in dealing with topology design to obtain a controllable network. Moreover, the results also show under what circumstances a network system with multiple identical nodes is uncontrollable. In many applications, groups of identical nodes are connected to each other which is called network of groups. Here, we address the structural controllability problem for multiple groups of network systems which provides information on proper topology design at both network level (i.e., interconnection of groups) and node level (i.e., interconnection of nodes within a group).
Early Spironolactone Treatment Attenuates Heart Failure Development by Improving Myocardial Function and Reducing Fibrosis in Spontaneously Hypertensive Rats

Background: We evaluated the role of the aldosterone blocker spironolactone in attenuating long-term pressure overload-induced cardiac remodeling and heart failure (HF) in spontaneously hypertensive rats (SHR). Methods and Results: Thirteen month-old male SHR were assigned to control (SHR-C, n=20) or spironolactone (SHR-SPR, 20 mg/kg/day, n=24) groups for six months. Normotensive Wistar-Kyoto rats (WKY, n=15) were used as controls. Systolic blood pressure was higher in SHR groups and unchanged by spironolactone. Right ventricular hypertrophy, which characterizes HF in SHR, was less frequent in SHR-SPR than SHR-C. Echocardiographic parameters did not differ between SHR groups. Myocardial function was improved in SHR-SPR compared to SHR-C [developed tension: WKY 4.85±0.68; SHR-C 5.22±1.64; SHR-SPR 6.80±1.49 g/mm2; -dT/dt: WKY 18.0 (16.0-19.0); SHR-C 20.8 (18.4-25.1); SHR-SPR 28.9 (24.2-34.6) g/mm2/s]. Cardiomyocyte cross-sectional area and total collagen concentration (WKY 1.06±0.34; SHR-C 1.85±0.63; SHR-SPR 1.28±0.39 µg/mg wet tissue) were greater in SHR-C than WKY and SHR-SPR. Type 3 collagen expression was lower in SHR-C than WKY and unchanged by spironolactone. Soluble collagen, type I collagen, and lysyl oxidase did not differ between groups. Conclusion: Early spironolactone treatment decreases heart failure development frequency by improving myocardial systolic and diastolic function and attenuating hypertrophy and fibrosis in spontaneously hypertensive rats.
Estimating the impact of enterprise resource planning project management decisions on post-implementation maintenance costs: a case study using simulation modelling

Organisations often make implementation decisions with little consideration for the maintenance phase of an enterprise resource planning (ERP) system, resulting in significant recurring maintenance costs. Poor cost estimations are likely related to the lack of an appropriate framework for enterprise-wide pre-packaged software maintenance, which requires an ongoing relationship with the software vendor (Markus, M.L., Tanis, C., and Fenema, P.C., 2000. Multisite ERP implementation. CACM, 43 (4), 42–46). The end result is that critical project decisions are made with little empirical data, resulting in substantial long-term cost impacts. The product of this research is a formal dynamic simulation model that enables theory testing, scenario exploration and policy analysis. The simulation model ERPMAINT1 was developed by combining and extending existing frameworks in several research domains, and by incorporating quantitative and qualitative case study data. The ERPMAINT1 model evaluates tradeoffs between different ERP project management decisions and their impact on post-implementation total cost of ownership (TCO). Through model simulations a variety of dynamic insights were revealed that could assist ERP project managers. Major findings from the simulation show that upfront investments in mentoring and system exposure translate to long-term cost savings. The findings also indicate that in addition to customisations, add-ons have a significant impact on TCO.
A hooded exposure chamber method for semiquantitative latex aeroallergen challenge.

BACKGROUND Allergen challenges are useful in adjudicating discordant clinical histories and skin test responses, serologic test responses, or both, as well as in determining the degree of allergic reactivity. Latex allergen challenges have been developed but have limitations that reduce their usefulness. OBJECTIVE We sought to develop a novel hooded exposure chamber (HEC) system to allow safe, sensitive, and semiquantitative evaluation of respiratory latex allergy. METHODS The HEC system uses an impinger to produce a particle cloud of cornstarch isolated from powdered latex gloves. The particles are air driven into a face shield and hood to simultaneously challenge the subject's conjunctiva, nose, and lungs during 3 minutes of normal tidal breathing. A cloud of respirable latex allergen-associated cornstarch particles (LACs) is consistently produced in the HEC during challenges. Twenty-three subjects with latex allergy (history and positive skin test response, positive serologic test response, or both) and 3 atopic control subjects not allergic to latex (history and negative skin test response, negative serologic test response, or both) were sequentially exposed to air, control cornstarch, and then progressive 2-fold increments of LACs in a single-masked fashion. A positive challenge result was defined as (1) a peak expiratory flow rate decline of 15% or greater from baseline; (2) a peak expiratory flow rate decline of 10% or greater and an increase of either the rhinoconjunctivitis or chest symptom score scale of 3 or more points from baseline; or (3) an increase of either the rhinoconjunctivitis or chest symptom score scale of 6 or more points from baseline. RESULTS Twenty-two of the 23 subjects with latex allergy reached threshold criteria for a positive challenge at LAC titers of 1:8 or greater, giving a sensitivity of 0.96. Challenge endpoints were moderately corrected with skin test sensitivity (r (s) = -0.55, P =. 01) but not with RAST reactivity. None of the 3 control subjects responded to LACs at the 1:8 dilution. No patient or control subject responded to the air or control cornstarch control exposures. All responses were confined to mild symptoms of allergic rhinoconjunctivitis, asthma, or both that either resolved spontaneously or were easily reversed with inhaled albuterol. No subject experienced a systemic or late-phase reaction. CONCLUSION The HEC procedure is a safe, sensitive, and specific method for masked semiquantitative latex aeroallergen challenges that mimic occupational latex exposure to powdered latex gloves.
Design of EBG microstrip directional coupler with high directivity and coupling

In this paper, a novel microstrip directional coupler with high directivity and coupling is proposed. It is based on the introduction of an electromagnetic bandgap (EBG) structure on the coupled lines to strongly enhance the desired backward coupling at the design frequency. The use of microstrip technology implies that the even and odd modes propagate at different speeds. This property causes a frequency dependent interchange of the energy between the direct and isolated ports. By adjusting the total length of the device in order to achieve a null of energy at the isolated port at the design frequency, a very high directivity and coupling (51.2 dB and 1.36 dB, respectively, at 10 GHz in the example presented) is achieved in the novel directional coupler proposed.