Miracle-dz/UniFAR-FTUs huggingface dataset:
Demystifying the Research Process: A Career Intervention With Latinas

Youth participatory action research (YPAR) is a methodology in which youth and researchers collaborate to engage in research within a shared community. This article describes a career intervention conducted with Latina middle school students using YPAR in the school’s Latino community outreach program. Participating students were members of the Latina science club #CHICAS, which was founded by the school counselor. A Latina school parent and researcher collaborated to structure the YPAR exercise. This project allowed Latina students to undertake aspects of the research process within the framework of their communities’ interests, while educating the school counselor about the specific needs of the Latino community. The YPAR exercise also developed skills students could transfer to future career options, such as being able to listen to conversational Spanish while simultaneously translating and transcribing written responses in English. The program highlighted students’ ability to coordinate multiple perspectives as they were informing their school’s administrators while transparently communicating the needs of their ethnic communities. This article highlights YPAR as an effective, mutually beneficial tool for school counselors to engage their ethnically diverse student populations.
2-Methyl-2,4-di-4-pyridyl-2,3-dihydro-1H-1,5-benzodiazepine acetic acid solvate

In the title compound, C20H18N4·CH3COOH, the benzene ring forms dihedral angles of 81.34 (11) and 54.32 (11)° with the two pyridine rings. In the crystal, intermolecular O—H⋯N hydrogen bonding links one 1,5-benzodiazepine molecule and one acetic acid solvent molecule into a dimer. These dimers, related by translation along the b axis, are further linked into chains via weak intermolecular N—H⋯N hydrogen bonds.
Global–local visual processing in posttraumatic stress disorder

The purpose of this study was to examine a behavioral index of hemispheric asymmetry (i.e., visual hierarchical attention) in posttraumatic stress disorder (PTSD), a disorder characterized by anxiety and other emotional symptoms. A reaction time based, computerized, global–local visual paradigm was administered to 26 PTSD-diagnosed and 22 psychopathology-free right-handed, male Vietnam War zone veterans. Results indicated that PTSD-diagnosed veterans displayed slower reaction times to all targets than the no-mental disorders comparison sample. However, findings also revealed a Group × Target location interaction in which the PTSD group was slower than the no-disorders comparison sample to respond to local, but not global, targets. Moreover, relative global bias was greater among PTSD-diagnosed veterans than their no-diagnosis counterparts. Findings provide partial support for the hypothesis that PTSD may be associated with a functional cerebral asymmetry favoring the right hemisphere. (JINS, 2004, 10, 709–718.)
The campaign to raise the tobacco tax in Massachusetts.

OBJECTIVES Question 1 raised the Massachusetts state tobacco tax to fund tobacco education programs. This paper examines the process of qualifying and passing Question 1. METHODS Information was gathered from internal memoranda, meeting minutes, newspaper articles, internal documents, letters, newsletters, news and press releases, and personal interviews. Data about campaign contributions were obtained from the Massachusetts Office of Campaign and Political Finance. RESULTS Three factors help explain why Question 1 passed: (1) the policy environment was favorable because of the social unacceptability of smoking; (2) the activists assembled a large coalition of supporters; and (3) the activists countered industry claims that the new tax would hurt small business and lower-income smokers and would be wasted by the legislature. The ballot initiative passed despite the industry's $7 million campaign to defeat it. CONCLUSIONS The apparent influence of the tobacco industry on the legislature was the driving force behind the decision of public health activists to qualify Question 1. Moving policy-making out of the legislature into the public arena widened the scope of conflict and enabled public health activists to win.
Socio-economic Factors and Adoption of ICT among staff members of Colleges of Education in Northwest zone of Nigeria

This research is financed by Tertiary Education Trust Fund (TETFUND), Nigeria Abstract This study examined the impact of socio-economic characteristics on ICT adoption by staff members in the fourteen (14) colleges of education located in northwest geo-political zone of Nigeria . A cross-sectional form of descriptive survey design was adopted. Though the population of this study was 15,219, comprising 5,845 and 9,374 academic and non-academic staff respectively a sample of 610 was used . A combination of simple random and stratified random sampling techniques was used to select the sample and data was collected through a self-completion structured questionnaire. Multiple linear regression model was used to test the main alternate hypothesis of the study at 95 per cent confidence level. Data analysis revealed that socio-economic variables have significant influence on IT adoption. Specifically, each of income, level of education, access to technology, age, gender and ownership of technology are predictors of level of ICT adoption. However, variables such as place of training, time of training, educational discipline and work experience do not have significant influence on the level of IT adoption. Hence, it was recommended that institutional heads should consider sales, training and maintenance agreement with hardware producers and software developers for the benefits of staff members. Employees should be encouraged to have access to expertise in data processing, graphics and publishing packages. Keywords: Adoption, Diffusion, Innovations, socio-economic characteristics, Information Technology, educational institutions, staff members DOI : 10.7176/IKM/9-2-07
Psychological perspectives in the patient with chronic orchialgia

Chronic orchialgia is a challenging problem to both the practitioner and unhappy patient and may be a poorly understood manifestation of a potential variety of different discrete causes. Treatment options can be wide ranging and include conservative measures, medical therapy, in office treatments and surgical procedures. Research has primarily focused on these more concrete treatment options with little focus on the either co-morbid or causative psychological issues. By at least considering the potential psychological co-morbidities and stressors that may be associated with chronic orchialgia, physicians can better utilize a multi-modal approach to this vexing problem.
Characterization of the Depletion of 2-C-Methyl-d-Erythritol-2,4-Cyclodiphosphate Synthase in Escherichia coli and Bacillus subtilis

ABSTRACT The ispF gene product in Escherichia coli has been shown to catalyze the formation of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate (MEC) in the deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis. In this work, the E. coli gene ispF and its Bacillus subtilis orthologue, yacN, were deleted and conditionally complemented by expression of these genes from distant loci in the respective organisms. In E. coli, complementation was achieved through integration of ispF at the araBAD locus with control from the arabinose-inducible araBAD promoter, while in B. subtilis, yacN was placed at amyE under control of the xylose-inducible xylA promoter. In both cases, growth was severely retarded in the absence of inducer, consistent with these genes being essential for survival. E. coli cells depleted of MEC synthase revealed a filamentous phenotype. This was in contrast to the depletion of MEC synthase in B. subtilis, which resulted in a loss of rod shape, irregular septation, multicompartmentalized cells, and thickened cell walls. To probe the nature of the predominant deficiency of MEC synthase-depleted cells, we investigated the sensitivity of these conditionally complemented mutants, grown with various concentrations of inducer, to a wide variety antibiotics. Synthetic lethal behavior in MEC synthase-depleted cells was prevalent for cell wall-active antibiotics.
Amniotic Membrane Transplantation or Conjunctival Limbal Autograft for Limbal Stem Cell Deficiency Induced by 5-fluorouracil in Glaucoma Surgeries

Purpose. To determine if human amniotic membrane transplantation or limbal stem cell transplantation is effective to restore the corneal surface with partial or total limbal stem cell deficiency, respectively, caused by 5-fluorouracil (5-FU) toxicity after glaucoma surgeries. Methods. Partial and total limbal stem cell deficiency was confirmed by impression cytology as the cause of reduced vision and corneal surface breakdown in a 69-year-old man and a 67-year-old man, respectively, who both had received a total of 105 mg 5-FU injections. Amniotic membrane transplantation or conjunctival limbal autograft was performed for corneal surface reconstruction, respectively. Results. For a period of 15 months of follow-up, the visual acuity improved, and their corneal surfaces remained avascular, smooth, and without recurrence of limbal stem cell deficiency. Conclusion. Limbal stem cell deficiency can occur as a late complication for patients receiving 5-FU after glaucoma filtering surgeries. Partial limbal stem cell deficiency can be treated with amniotic membrane transplantation alone, whereas limbal transplantation must be considered as an alternative for total limbal stem cell deficiency to restore the corneal surface integrity and vision.
The Role of ABS CDOs in the Financial Crisis

We examine the role of asset-backed security collateralized debt obligations (ABS CDOs) as a primary catalyst for the financial crisis. We show how ABS CDOs became the main investment vehicle for the riskiest investment-grade securities in the private-label mortgage market. We estimate a final tally of writedowns on ABS CDOs, $410 billion in total, with $325 billion assumed by AAA and “super-senior” securities, which had minimal capital, margin, or liquidity requirements. Pre-crisis regulations allowed excessive leverage at some firms investing in these securities, imperiling their solvency and placing them at the center of the financial crisis. TOPICS: Asset-backed securities (ABS), credit risk management, financial crises and financial market history
DESperately Seeking Service: A narrative review informing a disability employment services reform framework for Australians with mental illness.

BACKGROUND Notwithstanding efforts by vocational services to assist Australians with mental illness into employment many of these consumers remain unemployed. OBJECTIVE To inform policymakers and practitioners of a disability employment services reform framework that endeavours to help more consumers who are experiencing mental illness to attain and retain employment. METHODS Thematic analysis was directed to summarize results obtained from a narrative literature review of disability employment service reforms utilising Scopus, Medline and Pubmed databases and including articles published between 2000 and 2016. RESULTS Research results reveal a preparative framework covering three levels of disability employment services reform for consumers with mental illness. CONCLUSION This research makes important theoretical contributions across three areas. First this study reveals individualised, integrated and outcome-oriented services as dimensions of disability employment services reform that warrant greater government investment, practitioner focus and consumer involvement. Second recognising that none of these service reforms are immune from challenges which may hinder their effectiveness, future research is needed to identify evidence-based mitigation measures. Finally with individualised services positioned at the nucleus of the reform framework, integrated services and outcome-oriented reforms should be operationalised in ways that remain sensitive to the principle of strength-based support.
Inherited Defects in Platelet Signaling Mechanisms

In the majority of patients with an inherited abnormality in platelet function and a bleeding diathesis, the underlying platelet molecular mechanisms are unknown. The usually considered entities, such as thrombasthenia, the Bernard-Soulier syndrome, and storage pool deficiency, occur in a small proportion of patients. A substantial number of patients present with decreased aggregation and secretion of dense granule contents upon activation, and are lumped in the category of primary secretion defects or platelet activation defects. Evidence is now available that defects in platelet signaling mechanisms may be the basis for the platelet dysfunction in some of these patients. This evidence is presented here. If the key components in signal transduction are the surface receptors, the G-proteins, and the effectors, evidence now exists for specific human platelet abnormalities at each of these levels. There is a pressing need for a concerted effort to delineate the molecular mechanisms in the large group of patients with impaired platelet function who represent an untapped reservoir of new information into normal platelet function.
Central nervous system involvement in T-cell lymphoma: A single center experience

Abstract Background We characterized the incidence of central nervous system (CNS) involvement, risk factors and outcome in a large single institution dataset of peripheral T-cell lymphoma (PTCL). Methods Retrospective review of the PTCL database at Memorial Sloan Kettering Cancer Center. We identified 231 patients with any subtype of PTCL between 1994–2011 with a minimum six months of follow-up or an event defined as relapse or death. Results Histologies included peripheral T-cell lymphoma–not otherwise specified (PTCL–NOS) (31.6%), angioimmunoblastic (16.9%), anaplastic large cell lymphoma (ALCL), ALK- (12.1%), ALCL, ALK + (6.1%), extranodal NK/T-cell lymphoma (7.4%), adult T-cell leukemia/lymphoma (ATLL) (7.4%), and transformed mycosis fungoides (8.7%). Seventeen patients had CNS disease (7%). Fifteen had CNS involvement with PTCL and two had diffuse large B-cell lymphoma and glioblastoma. Median time to CNS involvement was 3.44 months (0.16–103.1). CNS prophylaxis was given to 24 patients (primarily intrathecal methotrexate). Rates of CNS involvement were not different in patients who received prophylaxis. Univariate analysis identified stage III–IV, bone marrow involvement, >1 extranodal site and ATLL as risk factors for CNS disease. On multivariate analysis, >1 extranodal site and international prognostic index (IPI) ≥ 3 were predictive for CNS involvement. The median survival of patients with CNS involvement was 2.63 months (0.10–75). Conclusions Despite high relapse rates, PTCL, except ATLL, carries a low risk of CNS involvement. Prognosis with CNS involvement is poor and risk factors include: >1 extra nodal site and IPI ≥3.
Implementing a transition pathway in diabetes: a qualitative study of the experiences and suggestions of young people with diabetes.

BACKGROUND The prevalence of Type 1 diabetes is increasing with more children and adolescents being diagnosed with this chronic condition. There has been an increasing focus in recent years on the transition through adolescence and supporting young people who have chronic health conditions, with the recognition that young people are at risk of dropping out of healthcare services following transfer from paediatric to adult services. To date, there have been limited evaluations of transition models. The purpose of this study is to evaluate one such model in diabetes, the 'Transition Pathway' via interviews with young people who have experienced it first-hand. The results are discussed in terms of understanding the unique needs of adolescents with regard to psychosocial developmental theory, and what this means for healthcare providers of transition/adolescent services. METHODS Semi-structured interviews were carried out with 11 young people, two of whom returned a year later for a second interview. Qualitative analysis of these interviews using a 'Framework' approach enabled the data to be sorted according to initial themes. Following this, further analysis enabled the identification of 'super-ordinate' or overall themes. RESULTS Six initial themes emerged from the data. These concerned the transition pathway process, the experience and organization of transfer, organization of services, information and education, the healthcare consultation and the need for services to be inclusive of all young people's needs. From these initial themes, two overall/super-ordinate themes were identified: the need for transition services to be developmentally appropriate and to be based around individual needs. The consultation experience was central to keeping young people engaged with adolescent healthcare services. CONCLUSION Several key elements of adolescent/transition healthcare services have been proposed, one of which is training for professionals delivering the service. This study suggests that communication skills form a vital component of such training.
Life Satisfaction of Employees, Labour Market Tightness and Matching Efficiency

PurposeDi Tella et al. (2001) show that temporary fluctuations in life satisfaction (LS) are correlated with macroeconomic circumstances such as gross domestic product, unemployment and inflation. In this paper, we bring attention to labour market measures from search and matching models (Pissarides 2000). Design/methodology/approachOur analysis follows the two-stage estimation strategy used in Di Tella et al. (2001) to explore sectoral unemployment levels, labour market tightness and matching efficiency as LS determinants. In the first stage, we use a large sample of individual data collected from a continuous web survey during the 2007–2014 period in the Netherlands to obtain regression-adjusted measures of LS by quarter and economic sector. In the second-stage, we regress LS measures against the unemployment level, labour market tightness and matching efficiency.FindingsOur results are threefold. First, the negative link between unemployment and an employee's LS is confirmed at the sectoral level. Second, labour market tightness, measured as the number of vacancies per job-seeker rather than the number of vacancies per unemployed, is shown to be relevant to the LS of workers. Third, labour market matching efficiency affects the LS of workers differently when they are less satisfied with their job and in temporary employment.Originality/valueNo evidence of this relationship has been documented before. Our results give support to government interventions aimed at activating demand for labour, improving the matching of job-seekers to vacant jobs and reducing information frictions by supporting match-making technologies.
Ten-Year Study on the Effect of Intrapartum Antibiotic Prophylaxis on Early Onset Group B Streptococcal and Escherichia coli Neonatal Sepsis in Australasia

Background: Intrapartum antibiotics have reduced the incidence of neonatal early onset (EO) group B streptococcal (GBS) disease. Some surveillance data suggest that this success may be at the cost of increasing rates of non-GBS infection, especially in premature neonates. Objective: To examine rates of EOGBS infection and EO Escherichia coli neonatal sepsis in Australasia. Methodology: Analysis of trends in EO (<48 h age) GBS and E. coli sepsis from longitudinal prospective surveillance data collected from representative tertiary obstetric hospitals in each state of Australia and selected centers in New Zealand during a 10-year period from 1992 through 2001. Statistical analysis used Poisson regression. Results: 206 GBS and 96 E. coli cases occurred in 298,319 live births during the study period. The EOGBS sepsis rate fell from a peak of 1.43/1000 live births in 1993 to 0.25/1000 in 2001 (P < 0.001). The overall EO E. coli sepsis rate was 0.32/1000. In babies with birth weight <1500 g, it was 6.20/1000. There was an overall trend to decreasing EO E. coli sepsis (P = 0.07), and there was no significant change in E. coli sepsis in babies <1500 g (P = 0.60). Sixty-nine percent of E. coli cases occurred in the <1500 g cohort; the case fatality rate in this group was 50%. The overall case fatality rate from E. coli sepsis was 36%, and this rate remained stable during the study period (P = 0.47). Conclusions: The increasing use of intrapartum antibiotics produced a steady decline in EOGBS disease in Australasia. There was also a trend to decreasing EO E. coli sepsis in all babies, and the rate in very low birth weight infants remained stable.
Economic voting in Brazilian presidential elections: evidence with panel data from municipalities in São Paulo

Abstract This paper uses a new data panel of 625 Brazilian municipalities over 5 election years to analyze the influence of the local level economic performance on the proportion of votes obtained by the incumbent in national elections. We examine municipalities from the State of São Paulo, the most populous Brazilian state, using fixed-effects and random- effects models. The results suggest that the performance of the local economy is relevant in the national elections. Apart from that, the results also suggest that the mayors play an important role in the national elections when it comes to transfer votes that are favorable to the coalition in power and that the richest municipalities tend to be more opposition prone.
Adenovirus 3 fiber polypeptide gene: implications for the structure of the fiber protein

The nucleotide sequence of a 1,330-base-pair-long DNA segment located between map coordinates 88.5 and 92.3 in the adenovirus type 3 (Ad3) genome was determined. Transcripts from the r-strand of the region were mapped by S1 nuclease analysis and by in vitro translation of RNA, selected by filter hybridization. The results revealed that the sequenced region encodes the Ad3 fiber polypeptide with a molecular weight of 34,800. A comparison between the predicted amino acid sequences of the Ad3 and the Ad2 fiber polypeptides revealed that they have almost identical secondary structures, consisting of a tail, a shaft, and a knob. A striking difference between Ad2 and Ad3 fibers was that the shaft of the Ad3 fiber was significantly shorter, containing only 6 repeat units compared with 22 in the Ad2 fiber. The secondary structure suggests that the fiber is a dimeric structure, as proposed earlier (N.M. Green, N.G. Wrigley, W.C. Russell, S.R. Martin, and A.D. McLachlan, EMBO J. 2:1357-1365, 1983), with the size of the polypeptide determining the length of the fiber protein.