Miracle-dz/UniFAR-FTUs huggingface dataset:
A Hybrid Agile model using SCRUM and Feature Driven Development

Migration is considered as crucial task especially in case of distributed projects. Banking domain, which involves sensitive business operations, is one such example which involves large volumes of data and transactions. Banking process is as old as history of human transactions, technological migration is necessary to cope up with the latest advancements to provide better service to the customers. For such a task, a single project management method deployment may not be strategically efficient, especially in terms of maintaining schedule and quality. For instance SCRUM and Feature Driven Development (FDD) are two well-known and popular project management methods with their own advantages and shortcomings. SCRUM, being tight with schedules, often quality may be compromised whereas FDD being quality rich, could overrun project time-line. In this paper for the first time, SCR-FDD, a purposeful amalgamation of SCRUM and FDD methodologies is proposed. The proposed SCR-FDD is evaluated against SCRUM and FDD within a real time project and the results show that proposed SCR-FDD is ten percent more efficient in terms of quality and customer satisfaction compared to its nearest counterpart, SCRUM.
Du verbe au nom : calques et décalages aspectuels

Notre contribution a pour theme l'analyse semantique des noms qui ont un correspondant morphologique dans le domaine verbal (e.g. construction, marche, accouchement, ignorance, decollage, etc.). Les etudes linguistiques consacrees a ces noms focalisent souvent sur leur structure argumentale et leur capacite a attribuer des roles thematiques a leurs complements (cf. Grimshaw 1990, Alexiadou 2001, etc.). Nous nous proposons de les aborder plus specifiquement sous l'angle de l'aspect lexical. Il s'agit de savoir si les noms en question sont dotes de proprietes aspectuelles comparables a celles des verbes correspondants. Apres avoir rappele la decomposition traditionnelle des proprietes d'aspect lexical dans le domaine verbal, en traits de dynamicite, de delimitation temporelle et de durativite, nous essayons de savoir si ces trois criteres se retrouvent dans le domaine nominal. Il est etabli dans un premier temps que seuls certains deverbaux sont dotes de proprietes aspectuelles. En effet, bien des noms lies morphologiquement a un verbe ont une signification concrete (agentive, instrumentale ou resultative) et, en tant que tels, ils ne sont pas susceptibles d'exprimer l'aspect. Dans le cas ou les traits aspectuels sont marques, ils sont souvent fideles a ceux des verbes correspondants, bien qu'ils ne soient pas toujours calques sur eux. On constate parfois une distorsion semantique entre le nom et le verbe. C'est le cas notamment dans le domaine des activites. Certains deverbaux d'activites, comptables et a meme de denoter des evenements (e.g. manifestation, discussion, promenade, etc.), impliquent une delimitation temporelle absente du semantisme de leur verbe d'origine. La transposition verbo-nominale implique-t-elle dans ce cas un changement de categorie aspectuelle ? Jusqu'a quel point la rupture semantique entre le verbe et le nom est-elle observee ? Nous verrons en dernier ressort que certaines distinctions aspectuelles traditionnellement admises dans le domaine verbal, comme la distinction entre predicats teliques et ateliques, demandent a etre precisees lorsqu'on les applique aux noms.
Septation deficiency and phosphilipid perturbation in Escherichia coli genetically constitutive for the beta oxidation pathway

Mutants of Escherichia coli defective in the regulation of the fatty acids beta oxidation pathway show an ultrastructural deficiency in septum formation at high growth rate. Several independent pairs of parent and mutant strains have been analyzed biochemically. Each parent strain displays a well-defined pattern of cellular phospholipids, which varies with the growth conditions. High ratios of phosphatidylglycerol to cardiolipin characterize fast-growth conditions. None of the mutant strains, although they grow in mass nearly as rapidly as their respective parents, can reach these high ratios. The beta oxidation pathway regulatory mutation leads to an increased turnover of the glycerol moieties of these phospholipids in the inner as well as in the outer cell membrane.
Mitogen-Activated Protein Kinases Control Cardiac KChIP2 Gene Expression

Hypertrophied myocardium is associated with reductions in the transient outward K+ current (Ito) and expression of pore-forming Kv4.2/4.3 and auxiliary KChIP2 subunits. Here we show that KChIP2 mRNA and protein levels are dramatically decreased to 10% to 30% of control levels in the left ventricle of aorta-constricted rats in vivo and phenylephrine (PE)-treated myocytes in vitro. PE also markedly decreases Ito density. Inhibition of protein kinase Cs (PKCs) does not affect the PE-induced reduction in KChIP2 mRNA level, whereas activation of PKC with phorbol ester (phorbol myristate [PMA]) causes a marked reduction in KChIP2 mRNA level. Pharmacological inhibition of MEKs or overexpression of a dominant-negative MEK1 increases the basal KChIP2 mRNA expression and blocks the PMA-induced decrease in auxiliary subunit mRNA level. In addition, a constitutively active MEK1 decreases the basal KChIP2 mRNA level, and PMA causes no further reduction in auxiliary subunit mRNA level in active MEK1-expressing cells. Furthermore, pharmacological inhibition of JNKs or overexpression of a dominant-negative JNK1 prevents the PE-induced, but not PMA-induced, reduction in KChIP2 mRNA expression. These results suggest that downregulation of KChIP2 expression significantly contributes to the hypertrophy-associated reduction in Ito density. They also indicate that the expression of KChIP2 mRNA is controlled by the 2 branches of mitogen-activated protein kinase pathways: JNKs play a predominant role in mediating the PE-induced reduction, whereas the MEK-ERK pathway influences the basal expression and mediates the PKC-mediated downregulation.
The Diffusion of Complex Market Technologies: Multifaceted Dynamics for Alternative Fuel Vehicles

This paper develops initial steps towards a framework for understanding factors that condition success and failure of complex market technologies. Dynamics of such technologies are conditioned by coevolutionary processes including the development of the installed base, consumer behavior, technologies, complementarities and interlinked supply chains. This paper analyzes diffusion patterns, including failures and successes, of alternative transportation fuel (ATF) and vehicle introductions, natural gas in New Zealand and Argentina, and ethanol in Brazil. I analyze the diffusion patterns of retrospective AFV introductions, failures and successes, through a behavioral dynamic simulation model. I characterize technology diffusion as a process of market formation which requires overcoming a period of fragility. During such a period at least one of the mechanisms conditioning its diffusion works against further spreading. Aggressive, simple strategies to overcome thresholds tend to fail. However, high potential strategies involve policy portfolios that are sustained, synchronized across multiple types of decision makers, and dynamic. Further, the efforts and their duration required to overcome this stage are strongly influenced by institutional and historical contexts. More broadly, the findings provide the groundwork for a framework to analyze processes of market formation for complex technologies. Such a framework involves capturing the fundamental mechanisms cutting across inter-organizational fields, but also includes important system-physiological aspects. Within this framework the traditional S-shaped diffusion curve is a special case with ex-ante usefulness confined to conditions of low market complexity and favorable institutional conditions. We discuss implications for policy and strategy.
Short‐versus long‐term Dual Antiplatelet therapy after drug‐eluting stent implantation in women versus men: A sex‐specific patient‐level pooled‐analysis of six randomized trials

Whether the efficacy and safety of dual antiplatelet therapy (DAPT) are uniform between sexes is unclear. We sought to compare clinical outcomes between short‐ (≤6 months) versus long‐term (≥1 year) DAPT after drug‐eluting stent (DES) placement in women and men.
Error Correcting Codes in Quantum Theory.

A new type of uncertainty relation is presented, concerning the information-bearing properties of a discrete quantum system. A natural link is then revealed between basic quantum theory and the linear error correcting codes of classical information theory. A subset of the known codes is described, having properties which are important for error correction in quantum communication. It is shown that a pair of states which are, in a certain sense, “macroscopically different,” can form a superposition in which the interference phase between the two parts is measurable. This provides a highly stabilized “Schrodinger cat” state. [S0031-9007(96)00779-X]
The N-terminal Domain Modulates α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Desensitization*

Background: The function of the AMPA receptor N-terminal domain (NTD) is unknown. Results: Deletion of the NTD leads to reduced desensitization and surface expression of GluA1–4 AMPA receptors. Conclusion: The NTD has a strong influence on the function and biosynthetic maturation of AMPA receptors. Significance: The NTD has the potential to mediate allosteric regulation of AMPA receptor signaling. AMPA receptors are tetrameric glutamate-gated ion channels that mediate fast synaptic neurotransmission in mammalian brain. Their subunits contain a two-lobed N-terminal domain (NTD) that comprises over 40% of the mature polypeptide. The NTD is not obligatory for the assembly of tetrameric receptors, and its functional role is still unclear. By analyzing full-length and NTD-deleted GluA1–4 AMPA receptors expressed in HEK 293 cells, we found that the removal of the NTD leads to a significant reduction in receptor transport to the plasma membrane, a higher steady state-to-peak current ratio of glutamate responses, and strongly increased sensitivity to glutamate toxicity in cell culture. Further analyses showed that NTD-deleted receptors display both a slower onset of desensitization and a faster recovery from desensitization of agonist responses. Our results indicate that the NTD promotes the biosynthetic maturation of AMPA receptors and, for membrane-expressed channels, enhances the stability of the desensitized state. Moreover, these findings suggest that interactions of the NTD with extracellular/synaptic ligands may be able to fine-tune AMPA receptor-mediated responses, in analogy with the allosteric regulatory role demonstrated for the NTD of NMDA receptors.
Possible role of tissue‐bound calcium ions in citrate‐mediated high‐temperature antigen retrieval

High‐temperature preheating of sections in the presence of a salt (e.g., citrate) or a protein denaturant (e.g., urea) solution has been shown recently to provide a reliable alternative to tissue proteolysis for antigen retrieval from formaldehyde‐fixed, paraffin‐embedded tissues. However, the underlying mechanism of action of this form of pretreatment remains highly speculative. In this study, we show that calcium chelating agents such EDTA and EGTA are more effective than citrate in the retrieval of a citrate‐sensitive nuclear antigen, Ki‐67. Also, sodium carbonate and another calcium precipitating agent are both able to effect antigen retrieval at high temperatures. The overall data therefore suggest that either the chelation or the precipitation of tissue‐bound calcium ions, and perhaps also other divalent metal cations, is a critical step in salt‐mediated antigen retrieval. As a corollary, it is suggested that tight complexing of calcium ions or other divalent metal cations with proteins during formaldehyde tissue fixation is responsible for the masking of certain antigens.
Mining Based Hybridization of Meta-RaPS

Though metaheuristics have been frequently employed to improve the performance of data mining algorithms, the opposite is not true. This paper discusses the process of employing a data mining algorithm to improve the performance of a metaheuristic algorithm. The targeted algorithms to be hybridized are the Meta-heuristic for Randomized Priority Search (Meta-RaPS) and an algorithm used to create an Inductive Decision Tree. This hybridization focuses on using a decision tree to perform on-line tuning of the parameters in Meta-RaPS. The process makes use of the information collected during the iterative construction and improvement phases Meta-RaPS performs. The data mining algorithm is used to find a favorable parameter using the knowledge gained from previous Meta-RaPS iterations. This knowledge is then used in future Meta-RaPS iterations. The proposed concept is applied to benchmark instances of the Vehicle Routing Problem. © 2014 The Authors. Published by Elsevier B.V. Selection and peer-review under responsibility of scientific committee of Missouri University of Science and Technology.
Adaptation au domaine de la traduction automatique statistique

Les performances de traduction des systemes statistiques dependent considerablement de la qualite et de la quantite des donnees d'apprentissage disponibles. Cependant, la plupart des corpus paralleles convenables et librement disponibles proviennent d'organisations internationales (ONU, Parlement europeen, etc.). En consequence, le "style" de ces donnees d'apprentissage n'est pas tres approprie pour construire un systeme de traduction adapte a des domaines particuliers. Nous presentons, alors, dans ce travail plusieurs techniques et approches pour adapter un systeme de traduction a un domaine different specifique pour lequel on dispose d'une quantite raisonnable de donnees d'apprentissage. Nous avons obtenu des ameliorations significatives du score BLEU avec des systemes de traduction "adaptes" de l'anglais vers le francais.
Evaluation of genetic causes of cardiomyopathy in childhood*

Abstract Cardiomyopathy frequently has a genetic basis. In adults, mutations in genes encoding components of the sarcomere, cytoskeleton, or desmosome are frequent genetic causes of cardiomyopathy. Although children share these causes, ~30% of children have an underlying metabolic, syndromic, or neuromuscular condition causing their cardiomyopathy, making the aetiologies more diverse in children as compared with adults. Although some children present with obvious signs or symptoms of metabolic, syndromic, or neuromuscular disease, other cases may be quite subtle, requiring a high level of suspicion in order to diagnose them. In general, the younger the child, the more extensive the differential. Advantages of identifying the underlying genetic cause of cardiomyopathy in the paediatric population include confirming the diagnosis in ambiguous cases, facilitating appropriate surveillance and management of cardiac and extra-cardiac diseases, providing prognostic information, and establishing the genetic basis in the family, thereby allowing the identification of at-risk relatives and institution of appropriate family screening as indicated. For these reasons, genetic testing is increasingly recognised as standard of care, and guidelines for genetic counselling, testing, and incorporation of family-based risk assessment have been established. Therapies aimed at treating specific genetic aetiologies of cardiomyopathy are emerging and are exciting new developments that require increasingly sophisticated approaches to diagnosis. As genetic testing capabilities continue to expand technically, careful interpretation, knowledgeable clinical utilisation, and appropriate dissemination of genetic information are important and challenging components of clinical care.
A Theory of Single-Event Transient Response in Cross-Coupled Negative Resistance Oscillators

A theory of the circuit-based response to SET phenomena in resonant tank oscillators is presented. Transients are shown to be caused by a change in the voltage state of the circuit's characteristic differential equation. The SET amplitude and phase response is derived for arbitrary strike waveforms and shown to be time-variant based on the strike time relative to the period of oscillation. Measurements in the time-domain are used to support the theory, while the frequency-domain is used to gauge potential impact on system performance. A design-oriented analysis of the relevant trade-offs is also presented.
Association of Human Papillomavirus Type 16 E7 and HLA Class I Antigen Expression in Cervical Premalignant and Malignant Lesions

In the present experiment we studied the correlation between HPV16 infection and expression of HLA-I antigen in cervical premalignant and malignant lesions (cervicitis, CIN, cervical squamous carcinomas and adenocarcinoma samples). The HPV16 E7 DNA load and the expression of HLA-I antigen in the samples were measured by real-time fluorescence quantitative polymerase chain reaction (RFQ-PCR) and immunohistochemical S-P staining, respectively. Our data indicate that HPV16 E7 load was highly and positively associated with the development of cervical lesions (Spearman's correlation coefficient r=0.848, p<0.001), the negative rate of HLA-I antigen was significantly distinguished among groups (p<0.001), and HPV16 E7 infection and downregulation of HLA-I antigen were highly correlated in cervical lesions (Pearson's correlation coefficient r=-0.487, p<0.001). HPV16 E7 may play an important role in the downregulation of HLA-I antigen in cervical lesions, which results in the immune escape of the virus and the occurrence, development, invasion and metastasis of cancer. Furthermore, quantitative PCR for HPV16 E7 may play an important role in the early detection of cervical diseases and in guiding future therapy toward prevention.
Progesterone-Induced Blocking Factor Activates STAT6 via Binding to a Novel IL-4 Receptor1

Progesterone-induced blocking factor (PIBF) induces Th2-dominant cytokine production. Western blotting and EMSA revealed phosphorylation as well as nuclear translocation of STAT6 and inhibition of STAT4 phosphorylation in PIBF-treated cells. The silencing of STAT6 by small interfering RNA reduced the cytokine effects. Because the activation of the STAT6 pathway depends on the ligation of IL-4R, we tested the involvement of IL-4R in PIBF-induced STAT6 activation. Although PIBF does not bind to IL-4R, the blocking of the latter with an Ab abolished PIBF-induced STAT6 activation, whereas the blocking of the IL-13R had no effect. PIBF activated suppressor of cytokine signaling-3 and inhibited IL-12-induced suppressor of cytokine signaling-1 activation. The blocking of IL-4R counteracted all the described effects, suggesting that the PIBF receptor interacts with IL-4R α-chain, allowing PIBF to activate the STAT6 pathway. PIBF did not phosphorylate Jak3, suggesting that the γ-chain is not needed for PIBF signaling. Confocal microscopic analysis revealed a colocalization and at 37°C a cocapping of the FITC PIBF-activated PIBF receptor and PE anti-IL-4R-labeled IL-4R. After the digestion of the cells with phosphatidylinositol-specific phospholipase C, the STAT6-activating effect of PIBF was lost, whereas that of IL-4 remained unaltered. These data suggest the existence of a novel type of IL-4R composed of the IL-4R α-chain and the GPI-anchored PIBF receptor.
Textbook in Psychiatric Epidemiology (2nd edn)

This is the second edition of a textbook first published in 1995. Like the first, it developed out of the Harvard Program in Psychiatric Epidemiology and Biostatistics. Like all second editions, it has expanded: from 483 pages to 722 and from 20 chapters to 24. Continuity has been maintained between the editions by having most of the original authors provide updates to their chapters. This is clearly an American textbook. At one level this is entirely reasonable, as the USA is easily able to assemble authors of the highest quality in this, as in every other, mainstream academic field. However, it was a criticism aimed at the first edition that it had a strong, perhaps overstrong, American focus. The editors have tried to remedy this (6 of the 48 authors are now European, of whom 4 are based in Britain). However, the American slant remains. It is apparent in the studies referenced and in the theoretical positions adopted. Thus, the only references to the British and Australian national surveys of psychiatric disorder are in Jane Murphy’s chapter on methodology whereas the American National Comorbidity Survey, for all its difficulties, has a chapter to itself. There is also something of a biological preference, which Europeans in particular are probably moving away from. This is illustrated in the (generally very good) chapter on the epidemiology of schizophrenia, where the evidence regarding the impact of stress on the development of psychosis is considerably downplayed. The chapter on methods in psychiatric genetics, by Faraone et al, stands out by its openhandedness regarding the role of the environment. For readers from Europe or elsewhere outside the USA, the North American focus probably does not matter, as they will be exposed to other viewpoints and other studies. It may, however, matter for the American reader who will not be encouraged by this book to see outside the circle.