Miracle-dz/UniFAR-FTUs huggingface dataset:
Bioactive technologies for hemocompatibility

The contact of any biomaterial with blood gives rise to multiple pathophysiologic defensive mechanisms such as activation of the coagulation cascade, platelet adhesion and activation of the complement system and leukocytes. The reduction of these events is of crucial importance for the successful clinical performance of a cardiovascular device. This can be achieved by improving the hemocompatibility of the device materials or by pharmacologic inhibition of the key enzymes responsible for the activation of the cascade reactions, or a combination of both. Different strategies have been developed during the last 20 years, and this article attempts to review the most significant, by dividing them into three main categories: bioinert or biopassive, biomimetic and bioactive strategies. With regard to bioactive strategies, particular attention is given to heparin immobilization and recent related technologies. References from both scientific literature and commercial sites are provided. Future development and studies are suggested.
Fear of Failure: An Exemplar for Social Development Research in Sport

Professionals in kinesiology and sport psychology have a wonderful opportunity to foster children's social development because of the importance of sport as an achievement domain for children. Fear of failure (FF) represents one achievement-related conshuct associated with a number of negative outcomes both in and out of the physical activity arena. The present article has three purposes. First, the literature on fear of failure over the past half century is reviewed; a multidimensional model of FF appraisals is recommended for future consideration. Second, research on the development of FF is reviewed with an emphasis on three interpersonal paths of influence: (a) family shucture and climate, (b) parental demands for independence and mastery, and (c) parent-child communications. Research findings are integrated with existing theory to synthesize an attachment-based interpretation of FE. Finally, specific directions for future science-practice efforts loward FF prevention and treatment are discussed.
Ribosome Synthesis-Unrelated Functions of the Preribosomal Factor Rrp12 in Cell Cycle Progression and the DNA Damage Response

ABSTRACT Given the high metabolic cost required to generate ribosomes, it has been assumed that proteins involved in ribosome synthesis might establish functional cross talk with other intracellular processes to efficiently couple ribosome production and cell growth. However, such interconnections have remained elusive due to the difficulty in separating the intra- and extraribosomal roles of ribosome biogenesis factors. Using a yeast functional screen, I have discovered that Rrp12, a conserved protein involved in ribosome maturation and export, plays roles in the cell cycle and the DNA damage response. These results indicate that Rrp12 participates in a karyopherin Kap121-dependent import route that is crucial for nuclear sequestration of ribonucleotide reductase subunits and, thereby, ensures the proper kinetics of deoxyribonucleotide production during the cell cycle. Within this route, Rrp12 acts as a cofactor important for the full functionality of Kap121. This activity is mechanistically different from the known roles of Rrp12 in ribosome biogenesis. I propose that the functional duality of Rrp12 may couple the control of ribosome production to the regulation of other cellular processes during cell cycle progression.
Data Management for the Internet of Things: Design Primitives and Solution

The Internet of Things (IoT) is a networking paradigm where interconnected, smart objects continuously generate data and transmit it over the Internet. Much of the IoT initiatives are geared towards manufacturing low-cost and energy-efficient hardware for these objects, as well as the communication technologies that provide objects interconnectivity. However, the solutions to manage and utilize the massive volume of data produced by these objects are yet to mature. Traditional database management solutions fall short in satisfying the sophisticated application needs of an IoT network that has a truly global-scale. Current solutions for IoT data management address partial aspects of the IoT environment with special focus on sensor networks. In this paper, we survey the data management solutions that are proposed for IoT or subsystems of the IoT. We highlight the distinctive design primitives that we believe should be addressed in an IoT data management solution, and discuss how they are approached by the proposed solutions. We finally propose a data management framework for IoT that takes into consideration the discussed design elements and acts as a seed to a comprehensive IoT data management solution. The framework we propose adapts a federated, data- and sources-centric approach to link the diverse Things with their abundance of data to the potential applications and services that are envisioned for IoT.
Organizational creativity diluted: a critical appraisal of discursive practices in academic research

Purpose – The purpose of this paper is to explore the discursive practices employed in academic research on organizational creativity through a critical lens. Design/methodology/approach – The literature on organizational creativity is reviewed from a discourse-theoretical perspective and three groupings of dominant discursive practices are identified. The theoretical and practical implications of the practices are discussed, and other potential aspects of creativity that appear to have been neglected or suppressed in the discourse are further examined. Findings – The dominant discursive practices in the organizational creativity research contribute to the building of a simplified and one-sided picture of organizational creativity; a stripped-down and diluted version that is more easily achievable and manageable, and leads to positive outcomes. Failure to recognize its inherent complexities reduces the value of creativity as an organizational asset. Originality/value – The findings contribute to the organ.
Tempo- and Transposition-invariant Identification of Piece and Score Position

We present an algorithm that, given a very small snippet of an audio performance and a database of musical scores, quickly identifies the piece and the position in the score. The algorithm is both tempo- and transposition-invariant. We approach the problem by extending an existing tempoinvariant symbolic fingerprinting method, replacing the absolute pitch information in the fingerprints with a relative representation. Not surprisingly, this leads to a big decrease in the discriminative power of the fingerprints. To overcome this problem, we propose an additional verification step to filter out the introduced noise. Finally, we present a simple tracking algorithm that increases the retrieval precision for longer queries. Experiments show that both modifications improve the results, and make the new algorithm usable for a wide range of applications.
Context-aware monitoring model using fuzzy logic for Wireless Sensor Networks in logistics

In most monitoring applications, Wireless Sensor Networks (WSNs) are configured to monitor and transmit the sensing data periodically. In case of normal conditions, when the environment does not change frequently, the collected values are usually the same. Hence, the received data do not provide enough meaningful information for making decisions. In this paper, we propose a flexible context-aware monitoring model based on fuzzy logic which can analyze and give the corresponding actions according to the environment changes for logistics contexts. This model can make sensor nodes more advanced to prolong the node lifetime and reduce the number of transmissions of unnecessary information. The simulation and experiment are performed to illustrate advantages of the proposed model and compared with the normal monitoring of sensor nodes in term of generated traffic load and energy efficiency.
Multi-class support vector machines: a new approach

We propose a new approach for solving multiclass problems with support vector machines. We modify the existing technique to properly reduce the empirical error, therefore we will be ideally able to outperform the previously proposed scheme for multi-class SVMs. The proposed approach also provides solutions with a significant reduction in the number of support vectors, which is an important feature for fast systems.
Valor e significado da vivência no primeiro ano do curso de medicina: apreciação de aprendizado pessoal e contexto em uma série histórica

The purpose of this study was to appraise how medical students perceive their first-year experiences in the medical course using an adapted version of the Course Valuing Inventory (CVI), and to analyse the relationships between the CVI scores and the students' individual attributes and academic achievements. The study involved 609 students and covered a period of ten years. The results showed relative stability of CVI scores in consecutive classes and significant differences among students when grouped by sex, place of birth, career choice, and term of enrolment in the program. Other findings were the significant relationships between CVI score and self-confidence, willingness to learn and cognitive achievement, and peer tutoring activity during four consecutive terms. GLM tests (between subjects and effects) identified four principal independent factors to explain the CVI-score variability: willingness to learn, self-confidence, career choice and term of enrolment. The discussion appraises the findings in relation to concepts of the students, internal context and educational context. In conclusion, CVI responses reflect a perspective of valuing personal learning in interaction with dimensions of the educational context. Accordingly, this tool can be considered useful for the pedagogical supervision of medical students' professional initiation.
A New Approach for Overlay Text Detection and Extraction From Complex Video Scene

Overlay text brings important semantic clues in video content analysis such as video information retrieval and summarization, since the content of the scene or the editor's intention can be well represented by using inserted text. Most of the previous approaches to extracting overlay text from videos are based on low-level features, such as edge, color, and texture information. However, existing methods experience difficulties in handling texts with various contrasts or inserted in a complex background. In this paper, we propose a novel framework to detect and extract the overlay text from the video scene. Based on our observation that there exist transient colors between inserted text and its adjacent background, a transition map is first generated. Then candidate regions are extracted by a reshaping method and the overlay text regions are determined based on the occurrence of overlay text in each candidate. The detected overlay text regions are localized accurately using the projection of overlay text pixels in the transition map and the text extraction is finally conducted. The proposed method is robust to different character size, position, contrast, and color. It is also language independent. Overlay text region update between frames is also employed to reduce the processing time. Experiments are performed on diverse videos to confirm the efficiency of the proposed method.
Heat Shock Protein 96 Is Elevated in Rheumatoid Arthritis and Activates Macrophages Primarily via TLR2 Signaling 1

Macrophages are important mediators of chronic inflammation and are prominent in the synovial lining and sublining of patients with rheumatoid arthritis (RA). Recently, we demonstrated increased TLR2 and TLR4 expression and increased response to microbial TLR2 and TLR4 ligands in macrophages from the joints of RA. The current study characterized the expression of the 96-kDa heat shock glycoprotein (gp96) in the joints of RA and its role as an endogenous TLR ligand to promote innate immunity in RA. gp96 was increased in RA compared with osteoarthritis and arthritis-free control synovial tissues. The expression of gp96 strongly correlated with inflammation and synovial lining thickness. gp96 was increased in synovial fluid from the joints of RA compared with disease controls. Recombinant gp96 was a potent activator of macrophages and the activation was mediated primarily through TLR2 signaling. The cellular response to gp96 was significantly stronger with RA synovial macrophages compared with peripheral blood monocytes from RA or healthy controls. The transcription of TLR2, TNF-α, and IL-8, but not TLR4, was significantly induced by gp96, and the induction was significantly greater in purified RA synovial macrophages. The expression of TLR2, but not TLR4, on synovial fluid macrophages strongly correlated with the level of gp96 in the synovial fluid. The present study documents the potential role of gp96 as an endogenous TLR2 ligand in RA and provides insight into the mechanism by which gp96 promotes the chronic inflammation of RA, identifying gp96 as a potential new therapeutic target.
Optimal dynamic vertical ray shooting in rectilinear planar subdivisions

In this paper we consider the dynamic vertical ray shooting problem, that is the task of maintaining a dynamic set S of n non intersecting horizontal line segments in the plane subject to a query that reports the first segment in S intersecting a vertical ray from a query point. We develop a linear-size structure that supports queries, insertions and deletions in O(log n) worst-case time. Our structure works in the comparison model and uses a RAM.
Reliability Generalization of Curriculum-Based Measurement Reading Aloud: A Meta-Analytic Review

The purpose of this study was to employ the meta-analytic method of Reliability Generalization to investigate the magnitude and variability of reliability estimates obtained across studies using Curriculum-Based Measurement reading aloud. Twenty-eight studies that met the inclusion criteria were used to calculate the overall mean reliability of Curriculum-Based Measurement reading aloud. The estimated mean alternate-form and test-retest reliability were . 89 and . 95, respectively. Yet it was difficult to generalize such a high reliability estimate for scores on Curriculum-Based Measurement reading aloud due to significant variability between and within studies. Grade level, testing interval length, universal screening/progress monitoring distinction, and ratio of students receiving special education services were significant moderator variables contributing to the variability found in the alternate-form reliability of Curriculum-Based Measurement reading aloud.
Characteristics of Pure-shear Mode BAW Resonators Consisting of (1120) Textured ZnO Films

Thickness pure-shear mode film bulk acoustic wave resonators (PBARs) made of (112 macr0) textured ZnO films have been fabricated. We also have fabricated FBAR structure consisting of two layers of the (112 macr0) textured ZnO film with opposite polarization directions. This FBAR structure operated in second overtone pure-shear mode and allowed shear-mode FBARs at higher frequency. The effective electromechanical coupling coefficients keff 2 of pure- shear mode FBAR and second overtone pure-shear mode FBAR in this study were found to be 3.3% and 0.8%, respectively. The temperature coefficient of frequency (TCF) of thickness extensional mode FBAR, pure-shear mode FBAR, and second overtone pure-shear mode FBAR were measured in the temperature range of 10-60degC. TCF values of -63.1 ppm/degC, -34.7 ppm/degC, and -35.6 ppm/degC were found for the thickness extensional mode FBAR, the pure- shear mode FBAR, and the second overtone pure-shear mode FBAR, respectively. These results demonstrated that pure-shear mode ZnO FBARs have more stable temperature characteristics than the conventional thickness extensional mode ZnO FBARs.
Sec34p, a Protein Required for Vesicle Tethering to the Yeast Golgi Apparatus, Is in a Complex with Sec35p

A screen for mutants of Saccharomyces cerevisiae secretory pathway components previously yielded sec34, a mutant that accumulates numerous vesicles and fails to transport proteins from the ER to the Golgi complex at the restrictive temperature (Wuestehube, L.J., R. Duden, A. Eun, S. Hamamoto, P. Korn, R. Ram, and R. Schekman. 1996. Genetics. 142:393–406). We find that SEC34 encodes a novel protein of 93-kD, peripherally associated with membranes. The temperature-sensitive phenotype of sec34-2 is suppressed by the rab GTPase Ypt1p that functions early in the secretory pathway, or by the dominant form of the ER to Golgi complex target-SNARE (soluble N-ethylmaleimide sensitive fusion protein attachment protein receptor)–associated protein Sly1p, Sly1-20p. Weaker suppression is evident upon overexpression of genes encoding the vesicle tethering factor Uso1p or the vesicle-SNAREs Sec22p, Bet1p, or Ykt6p. This genetic suppression profile is similar to that of sec35-1, a mutant allele of a gene encoding an ER to Golgi vesicle tethering factor and, like Sec35p, Sec34p is required in vitro for vesicle tethering. sec34-2 and sec35-1 display a synthetic lethal interaction, a genetic result explained by the finding that Sec34p and Sec35p can interact by two-hybrid analysis. Fractionation of yeast cytosol indicates that Sec34p and Sec35p exist in an ∼750-kD protein complex. Finally, we describe RUD3, a novel gene identified through a genetic screen for multicopy suppressors of a mutation in USO1, which suppresses the sec34-2 mutation as well.
AC-DC current transfer difference estimation of thin-film multijunction TCs up to 1 MHz

This paper reports our recent progress in the estimation of ac-dc transfer difference of planar thin-film multijunction thermal converters (TCs) employed as primary current transfer standard for frequencies up to 1 MHz. A group of PMJTCs with rated heater resistance of 90-Ω have been compared by using a new automated measuring system. Type A uncertainty is less than 0.1 μA/A for all frequencies. A short description of the automated measuring system developed is reported and the results show that the experimental setup is suitable for the comparison of thin-film AC-DC current transfer standards for frequencies up to 1 MHz.
Developments in the concept of working memory.

The authors summarize developments in the concept of working memory as a multicomponent system, beginning by contrasting this approach with alternative uses of the term working memory. According to a 3-component model, working memory comprises a phonological loop for manipulating and storing speech-based information and a visuospatial sketchpad that performs a similar function for visual and spatial information. Both are supervised by a central executive, which functions as an attentional control system. A simple trace-decay model of the phonological loop provides a coherent account of the effects of word length, phonemic similarity, irrelevant speech, and articulatory suppression in verbal short-term memory tasks. This model of the loop has also proved useful in the analysis of neuropsychological, developmental and, cross-cultural data. The notion of the sketchpad is supported by selective interference with imagery in normal adults and by specific neuropsychological impairment. Analysis of the central executive is illustrated by work on deficits in the ability to coordinate subproccesses in Alzheimer's disease (AD). (PsycINFO Database Record (c) 2008 APA, all rights reserved)
LIDAR-assisted preview controllers design for a MW-scale commercial wind turbine model

Existing commercial wind turbine control algorithms are typically feedback only. Nacelle-based commercial light detection and ranging (LIDAR) systems, which can detect preview wind information in front of the turbine to be used in feedforward controller design, can improve wind turbine control performance compared to a baseline standard proportional-integral (PI) feedback controller. Combined feedforward and feedback collective pitch control strategies are investigated in this research for both mitigating tower fore-aft fatigue load above rated wind speed and enhancing power capture below rated wind speed. When the wind speed is above rated, we consider a collective pitch LQ-based preview control scheme that augments the existing feedback controller and uses a Kalman filter in the control loop as the observer. When the wind speed is below rated, we combine a tower foreaft feedback damping pitch controller with a feedforward controller designed through the method of Lagrange multipliers optimization. Control effectiveness verifications are conducted through FAST simulations with multiple turbulent wind cases.
Handicap After Stroke: How Does It Relate to Disability, Perception of Recovery, and Stroke Subtype?: The North East Melbourne Stroke Incidence Study (NEMESIS)

Background and Purpose— Knowledge of patterns of handicap after stroke and of the relationship among handicap, disability, perception of recovery, and stroke subtype is limited. The aim of this study was to assess handicap 3 and 12 months after first-ever stroke in a community-based study. Methods— All strokes occurring in a population of 133 816 people were found and assessed. Patients were classified as having cerebral infarction (CI) or intracerebral hemorrhage (ICH) according to imaging or autopsy findings. Cases of CI were categorized using the Oxfordshire stroke classification. Handicap, disability, and perception of recovery were assessed 3 and 12 months after stroke using the London Handicap Scale, Barthel Index, and the question “Have you made a complete recovery from your stroke? ” The association between disability and handicap was examined using Pearson’s correlation. Differences in handicap among subtypes of CI were evaluated using one-way ANOVA. Results— There were 264 cases of CI or ICH. Of surviving patients, 113 (59%) were assessed at 3 months and 107 (64%) at 12 months. The domains of handicap most affected were physical independence and occupation. Only half the variance in handicap was due to disability. Of patients without disability, those who claimed complete recovery were less handicapped than those who claimed incomplete recovery. Patients with total anterior circulation infarction were more handicapped at 3 and 12 months than those with other subtypes of CI. Conclusions— Stroke patients were handicapped across many domains. Handicap is only partly explained by disability. Stroke subtype should be considered in the interpretation of outcome data.
The ARM Millimeter Wave Cloud Radars (MMCRs) and the Active Remote Sensing of Clouds (ARSCL) Value Added Product (VAP)

Eugene E. Clothiaux, The Pennsylvania State University Mark A. Miller, Brookhaven National Laboratory Robin C. Perez, Pacific Northwest National Laboratory David D. Turner, Pacific Northwest National Laboratory Kenneth P. Moran, NOAA Environmental Technology Laboratory Brooks E. Martner, NOAA Environmental Technology Laboratory Thomas P. Ackerman, The Pennsylvania State University Gerald G. Mace, The University of Utah Roger T. Marchand, The Pennsylvania State University Kevin B. Widener, Pacific Northwest National Laboratory Daniel J. Rodriguez, Lawrence Livermore National Laboratory Taneil Uttal, NOAA Environmental Technology Laboratory James H. Mather, The Pennsylvania State University Connor J. Flynn, Pacific Northwest National Laboratory Krista L. Gaustad, Pacific Northwest National Laboratory Brian Ermold, Pacific Northwest National Laboratory