Miracle-dz/UniFAR-FTUs huggingface dataset:
Feasibility of chemohyperthermia with docetaxel‐embedded magnetoliposomes as minimally invasive local treatment for cancer

Hyperthermia is a minimally invasive approach to cancer treatment, but it is difficult to heat only the tumor without damaging surrounding tissue. To solve this problem, we studied the effectiveness of chemohyperthermia with docetaxel‐embedded magnetoliposomes (DMLs) and an applied alternating current (AC) magnetic field. Human MKN45 gastric cancer cells were implanted in the hind limb of Balb‐c/nu/nu mice. Various concentrations of docetaxel‐embedded DMLs were injected into the tumors and exposed to an AC magnetic field (n = 6, each). For comparison with hyperthermia alone, magnetite‐loaded liposome (ML)‐injected tumors were exposed to an AC magnetic field. Furthermore, the results of DML without AC treatment and docetaxel diluted into PBS with AC treatment were also compared (n = 10, each). Tumor surface temperature was maintained between 42 and 43°C. Tumor volume was reduced in the DML group with a docetaxel concentration > 56.8 μg/ml, while a docetaxel concentration > 568.5 μg/ml was required for tumor reduction without hyperthermia. Statistically significant differences in tumor volume and survival rate were observed between the DML group exposed to the magnetic field and the other groups. The tumor disappeared in 3 mice in the DML group exposed to the magnetic field; 2 mice survived over 6 months after treatment, whereas all mice of the other groups died by 15 weeks. Histologically, hyperthermia with DML damaged tumor cells and DML diffused homogeneously. To the best of our knowledge, this is the first report to show that hyperthermia using chemotherapeutic agent‐embedded magnetoliposomes has an anticancer effect.
Model Checking for Multiagent Systems: the Mable Language and its Applications

We present MABLE, a fully implemented programming language for multiagent systems, which is intended to support the automatic verification of such systems via model checking. In addition to the conventional constructs of imperative programming languages, MABLE provides a number of agent-oriented development features. First, agents in MABLE are endowed with a BDI-like mental state: they have data structures corresponding to beliefs, desires, and intentions, and these mental states may be arbitrarily nested. Second, agents in MABLE communicate via ACL-like performatives: however, neither the performatives nor their semantics are hardwired into the language. It is possible to define the performatives and the semantics of these performatives independently of the system in which they are used. Using this feature, a developer can explore the design space of ACL performatives and semantics without changing the target system. Finally, MABLE supports automatic verification via model checking. Claims about the behaviour of a MABLE system can be expressed in a linear-time BDI-like logic, and the truth, or otherwise, of these claims can be automatically determined. Following a description of the MABLE language and the language of MABLE claims, we present two case studies to illustrate the language and its use in the verification of multiagent systems. We then describe the key ideas underpinning the current implementation of MABLE. Finally, we survey related work, and discuss some avenues for future research.
Distribution of Vesicular Glutamate Transporter 2 and Ionotropic Glutamate Receptors in the Auditory Ganglion and Cochlear Nuclei of Pigeons (Columba livia)

Glutamate is a principal excitatory neurotransmitter in the auditory system. Our previous studies revealed localization of glutamate receptor mRNAs in the pigeon cochlear nuclei, suggesting the existence of glutamatergic input from the auditory nerve to the brainstem. This study demonstrated localization of mRNAs for vesicular glutamate transporter 2 (vGluT2) and ionotropic glutamate receptors (AMPA, kainate and NMDA) in the auditory ganglion (AG) and cochlear nuclei (magnocellular, angular and laminar nuclei). VGluT2 mRNA was intensely expressed in AG and intensely or moderately in the cochlear nuclei. The AG and cochlear nuclei showed intense‐to‐moderate mRNA signals for GluA2, GluA3, GluA4, GluK4 and GluN1. These results suggest that the pigeon AG neurons receives glutamatergic input from hair cells and in turn projects to the magnocellular and angular nuclei. Glutamate may play a pivotal role in the excitatory synapse transmission in the peripheral auditory pathway of birds.
Factors influencing audiologists’ perception of moral climate in the workplace

Abstract Objective: The purpose of this study was to assess audiologists’ perceptions of ethics and moral climate in the workplace. Design: The Ethics Environmental Questionnaire (EEQ) was sent out to all audiologists registered with the professional body Audiology Australia. Participants were also invited to undertake a semi-structured interview. Study sample: A total of 301 audiologists completed the questionnaire. Eight of these participants also agreed to complete the interview. Results: The overall mean on the EEQ was approximately equivalent to that of a positive ethical environment, with the exception of those working in adult rehabilitation settings who scored significantly poorer. Scores were significantly associated with state and age. Qualitative analysis from the interviews found that sales pressure from employers was the dominant cause for concern amongst the group. Conclusions: For those working in adult rehabilitation, moral distress is most likely to occur as the result of conflicting goals between the organisation and the audiologist. There is a need to regulate the practice at an organisational as well as individual level to ensure the focus remains on ethical practice.
Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

The mTOR complex 1 (mTORC1) and endoplasmic reticulum (ER) stress pathways are critical regulators of intestinal inflammation and colon cancer growth. Sestrins are stress-inducible proteins, which suppress both mTORC1 and ER stress; however, the role of Sestrins in colon physiology and tumorigenesis has been elusive due to the lack of studies in human tissues or in appropriate animal models. In this study, we show that human SESN2 expression is elevated in the colon of ulcerative colitis patients but is lost upon p53 inactivation during colon carcinogenesis. In mouse colon, Sestrin2 was critical for limiting ER stress and promoting the recovery of epithelial cells after inflammatory injury. During colitis-promoted tumorigenesis, Sestrin2 was shown to be an important mediator of p53’s control over mTORC1 signaling and tumor cell growth. These results highlight Sestrin2 as a novel tumor suppressor, whose downregulation can accelerate both colitis and colon carcinogenesis. DOI: http://dx.doi. org/10.7554/eLife.12204. 001
Application Deployment Strategies for Spatial Isolation on Many-Core Accelerators

Current cache Side-Channel Attacks (SCAs) countermeasures have not been designed for many-core architectures and need to be revisited in order to be practical for these new technologies. Spatial isolation of resources for sensitive applications has been proposed taking advantage of the large number of resources offered by these architectures. This solution avoids cache sharing with sensitive processes. Consequently, their cache activity cannot be monitored and cache SCAs cannot be performed. This work focuses on the implementation of this technique in order to minimize the induced performance overhead. Different strategies for the management of isolated secure zones are implemented and compared.
High-Resolution Strain Mapping Through Time-of-Flight Neutron Transmission Diffraction

The spatial resolution of time of flight neutron transmission diffraction was recently improved by the extension of photon/electron counting technology to imaging of thermal and cold neutrons. The development of novel neutron sensitive microchannel plates enables neutron counting with spatial resolution of ~55 um and time-of-flight accuracy of ~1 us, with efficiency as high as 70% for cold and ~40% for thermal neutrons. The combination of such a high resolution detector with a pulsed collimated neuron beam provides the opportunity to obtain a 2-dimensional map of neutron transmission spectra in one measurement. The results of our neuron transmission measurements demonstrate that maps of strains integrated along the beam propagation direction can be obtained with ~100 microstrain accuracy and spatial resolution of ~100 um providing there are sufficient neutron events collected. In this paper we describe the capabilities of the MCP neutron counting detectors and present the experimental results of 2-dimensional strain maps within austenitic steel compact tension (CT) crack samples measured at the ENGIN-X beamline of the ISIS pulsed neutron source.
Immune function and the decision to deploy weapons during fights in the beadlet anemone, Actinia equina

ABSTRACT The ability to mitigate the costs of engaging in a fight will depend on an individual's physiological state. However, the experience of fighting itself may, in turn, affect an individual's state, especially if the fight results in injury. Previous studies have found a correlation between immune state and fighting success, but the causal direction of this relationship remains unclear. Does immune state determine fighting success? Or does fighting itself influence subsequent immune state? Using the beadlet anemone, Actinia equina, we disentangled the cause and effect of this relationship, measuring immune response once pre-fight and twice post-fight. Contrary to previous findings, pre-fight immune response did not predict fighting success, but rather predicted whether an individual used its weapons during the fight. Furthermore, weapon use and contest outcome significantly affected post-fight immune response. Individuals that used their weapons maintained a stable immune response following the fight, whereas those that fought non-injuriously did not. Furthermore, although winners suffered a reduction in immune response similar to that of losers immediately post-fight, winners began to recover pre-fight levels within 24 h. Our findings indicate that immune state can influence strategic fighting decisions and, moreover, that fight outcome and the agonistic behaviours expressed can significantly affect subsequent immunity. Summary: Strategic fighting decisions affect an individual's subsequent ability to mount an immune response in the beadlet anemone, Actinia equina.
Claper: Recommend classical papers to beginners

Classical papers are of great help for beginners to get familiar with a new research area. However, digging them out is a difficult problem. This paper proposes Claper, a novel academic recommendation system based on two proven principles: the Principle of Download Persistence and the Principle of Citation Approaching (we prove them based on real-world datasets). The principle of download persistence indicates that classical papers have few decreasing download frequencies since they were published. The principle of citation approaching indicates that a paper which cites a classical paper is likely to cite citations of that classical paper. Our experimental results based on large-scale real-world datasets illustrate Claper can effectively recommend classical papers of high quality to beginners and thus help them enter their research areas.
iCare: Automatic and User-friendly Child Identification on Smartphones

With the proliferation of smartphones, children often use the same smartphones of their parents to play games or surf Internet, and can potentially access kid-unfriendly content from the Internet jungle. It is critical to employ parent patrol mechanisms such that children are limited to child-friendly contents only. A successful parent patrol strategy has to be user-friendly and privacy-aware. The apps that require explicit actions from parents may not be effective when parents forget to enable them, and the ones that use built-in cameras to detect children may impose privacy violations. In this paper, we propose iCare, which can identify child users automatically and seamlessly as users operate smartphones. In particular, iCare investigates the intrinsic differences of screen-touch patterns between child and adult users. We discover that users' touch behaviors depend on a user's age. Thus, iCare records the touch behaviors and extracts hand-geometry and finger dexterity features that capture the age information. We conducted experiments on 31 people including 17 elementary school kids (3 to 11 years old) and 14 adults (22 to 60). Results show that iCare can achieve 84% accuracy for child identification using only a single swipe on the screen, and the accuracy becomes 97% with 8 consecutive swipes.
A review on gradient hydrogel/fiber scaffolds for osteochondral regeneration

Osteochondral tissue regeneration is a complicated field due to the distinct properties and healing potential of osseous and chondral phases. In a natural osteochondral region, the composition, mechanics, and structure vary smoothly from bony to cartilaginous phase. Therefore, a homogeneous scaffold cannot satisfy the complexity of the osteochondral matrix. In essence, a natural extracellular matrix is composed of fibrous proteins elongated into a gelatinous background. A hydrogel/fiber scaffold possessing gradient in both phases would be of the utmost interest to imitate tissue arrangement of a native osteochondral interface. However, there are limited research works that exploit hydrogel/fiber scaffolds for osteochondral restoration. In the present review, currently used fibrous or gelatinous scaffolds for osteochondral damages are discussed. Moreover, superiority of using gradient hydrogel/fiber composites for osteochondral regeneration and practical approaches to develop those scaffolds is debated.
Internet Gaming Disorder as a formative construct: Implications for conceptualization and measurement

Some people have serious problems controlling their Internet and video game use. The DSM‐5 now includes a proposal for ‘Internet Gaming Disorder’ (IGD) as a condition in need of further study. Various studies aim to validate the proposed diagnostic criteria for IGD and multiple new scales have been introduced that cover the suggested criteria. Using a structured approach, we demonstrate that IGD might be better interpreted as a formative construct, as opposed to the current practice of conceptualizing it as a reflective construct. Incorrectly approaching a formative construct as a reflective one causes serious problems in scale development, including: (i) incorrect reliance on item‐to‐total scale correlation to exclude items and incorrectly relying on indices of inter‐item reliability that do not fit the measurement model (e.g., Cronbach's α); (ii) incorrect interpretation of composite or mean scores that assume all items are equal in contributing value to a sum score; and (iii) biased estimation of model parameters in statistical models. We show that these issues are impacting current validation efforts through two recent examples. A reinterpretation of IGD as a formative construct has broad consequences for current validation efforts and provides opportunities to reanalyze existing data. We discuss three broad implications for current research: (i) composite latent constructs should be defined and used in models; (ii) item exclusion and selection should not rely on item‐to‐total scale correlations; and (iii) existing definitions of IGD should be enriched further.
COMPUTATIONAL LOGICS AND AGENTS: A ROAD MAP OF CURRENT TECHNOLOGIES AND FUTURE TRENDS

The concept of an agent is increasingly used in contemporary software applications, particularly those involving the Internet, autonomous systems, or cooperation. However, with dependability and safety in mind, it is vital that the mechanisms for representing and implementing agents are clear and consistent. Hence there has been a strong research effort directed at using formal logic as the basis for agent descriptions and agent implementation. Such a logical basis not only presents the clarity and consistency required but also allows for important techniques such as logical verification to be applied. We present a road map of research into the use of computational logic in agent‐based systems and survey much of the recent work in these areas. Even though, with such a rapidly changing field, it is impossible to cover every development, we aim to give the reader sufficient background to understand the current research problems and potential future developments in this maturing area.
Iterative fitting after elastic registration: An efficient strategy for accurate estimation of parametric deformations

Video phylogeny research about joint analysis of correlated video sequences has shown the possibility of developing interesting forensic applications. As an example, it is possible to study the provenance of near-duplicate (ND) video sequences, i.e., videos generated from the same original one through content preserving transformations. To perform this kind of analysis, accurate detection of ND videos is paramount. In this paper, we propose an algorithm for ND video detection and clustering in a challenging setup. Specifically, we analyze a scenario in which many videos, depicting the same event, are recorded by different users. This situation is critical as non-ND videos acquired from very close viewpoints run the risk of being incorrectly detected as ND. The proposed approach leverages on robust hashing properties and the concept of sensor noise traces.
Entrepreneurs from Technology-Based Universities

This paper analyzes major patterns and trends in entrepreneurship among technology-based university alumni since the 1930s by asking two related research questions: (1) Who enters entrepreneurship, and has this changed over time? ; and (2) How does the rate of entrepreneurship vary with changes in the entrepreneurial business environment? We describe findings based on data from two linked datasets joining Massachusetts Institute of Technology (MIT) alumni and founder information. New company formation rates by MIT alumni have grown dramatically over seven decades, and the median age of first time entrepreneurs has gradually declined from about age 40 (1950s) to about age 30 (1990s). Women alumnae lag their male counterparts in the rate at which they become entrepreneurs, and alumni who are not U.S. citizens enter entrepreneurship at different (often higher) rates relative to their American classmates. New venture foundings over time are correlated with measures of the changing external entrepreneurial and business environment, suggesting that future research in this domain may wish to more carefully examine such factors.
Sensitivity to Interaural Level Difference and Loudness Growth with Bilateral Bimodal Stimulation

The interaural level difference (ILD) is an important cue for the localization of sound sources. The sensitivity to ILD was measured in 10 users of a cochlear implant (CI) in one ear and a hearing aid (HA) in the other severely impaired ear. For simultaneous presentation of a pulse train on the CI side and a sinusoid on the HA side the just noticeable difference (JND) in ILD and loudness growth functions were measured. The mean JND for pitch-matched electric and acoustic stimulation was 1.7 dB. A linear fit of the loudness growth functions on a decibel-versus-microampere scale shows that the slope depends on the subject’s dynamic ranges.
Thermal Conductivity of Uranium Nitride and Carbide

We investigate the electronic thermal conductivity of alternative fuels like uranium nitride and uranium carbide. We evaluate the electronic contribution to the thermal conductivity, by combining first-principles quantum-mechanical calculations with semiclassical correlations. The electronic structure of UN and UC was calculated using Quantum Espresso code. The spin polarized calculations were performed for a ferromagnetic and antiferromagnetic ordering of magnetic moments on uranium lattice and magnetic moment in UC was lower than in UN due to stronger hybridization between 2p electrons of carbon and 5f electrons of uranium. The nonmagnetic electronic structure calculations were used as an input to BolzTrap code that was used to evaluate the electronic thermal conductivity. It is predicted that the thermal conductivity should increase with the temperature increase, but to get a quantitative agreement with the experiment at higher temperatures the interaction of electrons with phonons (and electron-electron scattering) needs to be included.
Learning Better Name Translation for Cross-Lingual Wikification

A notable challenge in cross-lingual wikification is the problem of retrieving English Wikipedia title candidates given a non-English mention, a step that requires translating names written in a foreign language into English. Creating training data for name translation requires significant amount of human efforts. In order to cover as many languages as possible, we propose a probabilistic model that leverages indirect supervision signals in a knowledge base. More specifically, the model learns name translation from title pairs obtained from the inter-language links in Wikipedia. The model jointly considers word alignment and word transliteration. Comparing to 6 other approaches on 9 languages, we show that the proposed model outperforms others not only on the transliteration metric, but also on the ability to generate target English titles for a cross-lingual wikifier. Consequently, as we show, it improves the end-to-end performance of a cross-lingual wikifier on the TAC 2016 EDL dataset.
Unravelling causal and temporal influences underpinning monitoring systems success: A typological approach

This paper is concerned with the causal and temporal underpinnings of information systems success. It uses a typological approach based on fuzzy‐set Qualitative Comparative Analysis and process tracing. It investigates success across multiple cases of information systems adopted for monitoring the disbursement and use of resources within the European Social Fund. The study unravels the causal mechanisms and temporal pathways underpinning success in these systems. It develops a typological theory of monitoring systems success that reveals the temporal pathways embedded within individual cases, as well as broader theoretical patterns emerging across cases. Theoretical, methodological, and practical implications are discussed.
Identification of Chlamydia trachomatis in a patient with ocular lymphoma

Accumulating evidence suggests that infectious agents may play a role in ocular adnexa lymphomas (OALs) of MALT-type [1-4]. In particular, Chlamydia psittaci, the causative agent of psittacosis, has been detected by PCR in most patients from Italy or isolated eastern Asiatic countries with OALs in absence of other Chlamydia species [4-8]. These patients have also been shown to have a complete or partial response to doxycycline, recognized to be a cheap and safe treatment in these patients [5,6]. In contrast, OAL patients from other geographic areas and with different genetic background were found to be negative for C. psittaci DNA or had a quite variable response to antibiotic treatment, assuming that this pathogen might not play a ubiquitous role in OALs and that bacterial infection is not associated with OAL [8-12].