Miracle-dz/UniFAR-FTUs huggingface dataset:
Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group.

BACKGROUND Cord-blood banks have increased the use of cord-blood transplantation in patients with hematologic disorders. We have established a registry containing information on the outcome of cord-blood transplantation. METHODS We sent questionnaires to 45 transplantation centers for information on patients receiving cord-blood transplants from 1988 to 1996. Reports on 143 transplantations, performed at 45 centers, were studied, and the responses were analyzed separately according to whether the donor was related or unrelated to the recipient. RESULTS Among 78 recipients of cord blood from related donors, the Kaplan-Meier estimate of survival at one year was 63 percent. Younger age, lower weight, transplants from HLA-identical donors, and cytomegalovirus-negative serologic results in the recipient were favorable prognostic factors. Graft-versus-host-disease of at least grade II occurred at estimated rates of 9 percent in 60 recipients of HLA-matched cord blood and 50 percent in 18 recipients of HLA-mismatched cord blood. Neutrophil engraftment was associated with an age of less than six years (P = 0.02) and a weight of less than 20 kg (P = 0.02), and it occurred in 85 percent of patients receiving 37 million or more nucleated cells per kilogram of body weight. Among 65 patients who received cord blood from unrelated donors, the Kaplan-Meier estimate of survival at one year was 29 percent. Cytomegalovirus-negative serologic status in these recipients was associated with improved survival (P = 0.03) and was the most important predictor of graft-versus-host disease (P = 0.04). Neutrophil recovery occurred in 94 percent of the patients who received 37 million or more nucleated cells per kilogram from unrelated donors. CONCLUSIONS Cord blood is a feasible alternative source of hematopoietic stem cells for pediatric and some adult patients with major hematologic disorders, particularly if the donor and the recipient are related.
Usage of the Inductive Energy Storage in the Field Winding for Driving the Variable Reluctance Motor

In automotive systems, reliability and cost are paramount for the success of electrical drive systems. Considering the switched reluctance motor (SRM), the power electronics cost dominates the total cost of the electrical drive. In this respect, especially the dc-link capacitor significantly contributes to the total bill of the material. This paper proposes the use of a dc-excited winding in an 8/6 SRM as a means of reducing the capacitor. The energy conversion of the motor is analyzed intensively. The control algorithm of the field winding is investigated and an active control algorithm is proposed to provide and absorb the energy in parallel with the dc-link capacitor. The effectiveness of this control method is confirmed by the cosimulation between the finite-element method and the Simulink.
How the Contact-Probing Mechanism Affects the Transmission Capacity of Delay-Tolerant Networks

Link duration is a main factor in determining the transmission capacity between two encounter nodes in delay-tolerant networks (DTNs). Existing research on DTN transmission capacity usually assumes that a node can immediately discover the nodes that move into its transmission range. Under this assumption, the link duration in DTNs is determined by the moving speed and transmission distance of encounter nodes. However, this assumption may be invalid in realistic DTNs, where the nodes use a contact-probing protocol to detect their neighbors. In this paper, we investigate the impact of contact-probing mechanisms on link duration and, thus, the transmission capacity of DTNs. We first derive the probability distribution of link duration and analyze the impact of contact-probing mechanisms on the total link durations. Based on this approach, we derive the theoretical node throughput and energy consumption and explore their tradeoff. In addition, we provide a framework for computing the optimal contact-probing frequency under energy limitations and adjust the probing frequency according to the node-encountering rate. Simulation experiments based on the Opportunistic Network Environment simulator validates the correctness and the accuracy of our analytical model. Our analytical results provide insights into how contact probing affects the DTN transmission capacity and energy consumption.
Terbium Sensitized Determination of Tosufloxacin Using Electrochemiluminescence Method

A novel method for determination of trace amounts of tosufloxacin (TFLX) based on electrochemiluminescence (ECL) has been developed. The calibration graphs for TFLX were linear in the range of 5.0 × 10^–11–3.5 × 10^–7 mol/L, with the detection limit of 1.3 × 10^–11 mol/L. Key factors affecting the determination of TFLX were investigated. TFLX amounts in capsule and serum samples were successfully detected by this method. A possible mechanism of energy transfer, and thus the explanation of ECL in the Tb^3+-TFLX-Na_2S_2O_4 system are discussed.
Turbulent solutal convection and surface patterning in solid dissolution.

We describe experiments in which crystals of NaCl, KBr, and KCl are dissolved from below by aqueous solutions containing concentrations of the respective salts from zero concentration to near saturation. The solution near the solid-liquid interface is gravitationally unstable, producing turbulent hydrodynamic motion similar to thermal convection from a single surface cooled from above. The coupling of the fluid flow with the solid dissolution produces irregular patterns at the solid-liquid interface with a distribution of horizontal length scales. The dissolution mass flux and the pattern length scales are compared with a turbulent boundary layer model. Remarkable agreement is found, showing that the fluid motion controls both the dissolution rate and the interface patterning. {copyright} {ital 1996 The American Physical Society. }
Segmentation of bathymetric profiles and terrain matching for underwater vehicle navigation

A terrain-based underwater navigation using sonar bathymetric profiles is presented. It deals with matching high-resolution local depth maps against a large on-board reference map. The matching algorithm locates the local depth map within the a priori known larger map to determine the absolute position and heading of the vehicle. Two separate approaches for this problem are presented. The first uses a contour-based representation of depth maps. Contours are extracted from both local and reference maps. Invariant attributes under rigid plane transformation are associated with each contour point, so that the problem is reduced to a point-based matching algorithm: given two point sets, find correspondences and estimate transformation between the two sets. We shall particularly focus on the formalism of partial differential equations, which is used to smooth depth maps in a morphologically invariant way and to obtain anisotropic contours. The second approach is also based on a correspondence algorithm. Here, .
Spinocerebellar degeneration

The spinocerebellar degenerations/ataxias (SCAs) are a diverse group of rare, slowly progressive, neurological diseases, often inherited but of incompletely understood pathophysiology, which affect the cerebellum and its related pathways. They have few animal models and share no reliable biomarkers. They have, as yet, no universally validated rating scale for use in clinical trials. In the past 25 years, there have been, at most, 18 controlled (Class 1) trials for ataxia, which have focused on neurotransmitter mechanisms. There is currently only one National Institute of Neurological Disorders and Stroke-sponsored drug trial for ataxia (Phase I study of idebenone in Friedreich’s ataxia). There are, as yet, no FDA-approved drugs for SCA. Current treatment practices encompass rehabilitation interventions and off-label use of symptomatic medications [1,2].
Cardinality of Subspace Multicomponent Codes

This paper is devoted to multicomponent subspace codes with zero prefix (MZP). The construction is described. The codes are divided into two parts. The first part contains the codes which code distance is not maximal. The second part contains of the codes with maximal code distance, so called partial spreads. It connects with different ways to estimate the upper bounds of cardinality. Cardinality for codes is calculated for different parameters. The obtained values are compared with the corresponding upper bounds. It is shown that the cardinality of the codes from the first part does not coincides with the upper bound. The cardinality of the partial spreads coincides or almost coincides with the upper bound. It depends on code dimension. By definition, efficiency is defined as ratio of the cardinality of the code for given parameters to the upper bound at the same parameters.
Task-model based human robot cooperation using vision

In order to assist a human, the robot must recognize human motion in real time by vision, and must plan and execute the needed assistance motion based on the task purpose and the context. In this research, we tried to solve such problems. We defined the abstract task model, analyzed the human demonstration by using events and an event stack, and automatically generated the task models needed in the assistance by the robot. The robot planned and executed the appropriate assistance motions based on the task: models according to the human motions in the cooperation with the human. We implemented a 3D object recognition system and a human grasp recognition system by using trinocular stereo color cameras and a real time range finder. The effectiveness of these methods was tested through an experiment in which the human and the robotic hand assembled toy parts in cooperation.
Tumor Heterogeneity Revealed by KRAS, BRAF, and PIK3CA Pyrosequencing: KRAS and PIK3CA Intratumor Mutation Profile Differences and Their Therapeutic Implications

Current clinical problems in colorectal cancer (CRC) diagnostics and therapeutics include the disease complexity, tumor heterogeneity, and resistance to targeted therapeutics. In the present study, we examined 171 CRC adenocarcinomas from Greek patients undergoing surgery for CRC to determine the frequency of KRAS, BRAF, and PIK3CA point mutations from different areas of tumors in heterogeneous specimens. Ninety two out of 171 (53.8%) patients were found to bear a KRAS mutation in codons 12/13. Of the 126 mutations found, 57.9% (73/126) were c.38G>A mutations (p.G13D) and 22.2% (28/126) were c.35G>T (p.G12V). Remarkably, RAS mutations in both codons 12 and 13 were recorded in the same tumor by pyrosequencing. Moreover, differences in KRAS mutations between tumor center and periphery revealed tumor heterogeneity in 50.7% of the specimens. BRAF c.1799T>A (V600E) mutations were moderately detected in 4/171 (2.3%) specimens, whereas most PIK3CA mutations were revealed by pyrosequencing 6/171 (3.5%). Remarkable tumor heterogeneity is revealed, where double mutations of KRAS in the same tumor and different KRAS mutation status between tumor core and margin are detected with high frequency. It is expected that these findings will have a major impact in cancer diagnosis and personalized therapies.
Homotopy Analysis Transform Method for Integro-Differential Equations

In this article, we propose a reliable combination between the homotopy analysis method (HAM) and Laplace transformation method (LTM ) to find the analytic approximate solution for integro-differential equat ions. This study represents significant features of HATM and its capability of handling integro-differential equations. Some illustrative examples are also pres ent d to demonstrate the validity and applicability of this technique. Compa rison between the obtained results by HATM and exact solution are shown integr o-differential equations to illustrate the effective of this method. This metho d is reliable and capable of providing analytic treatment for solving such equat ions. Homotopy Analysis Transform Method for. 33
Experimental and modelling evidence of shortening heat in cardiac muscle

Heat associated with muscle shortening has been repeatedly demonstrated in skeletal muscle, but its existence in cardiac muscle remains contentious after five decades of study. By iterating between experiments and computational modelling, we show compelling evidence for the existence of shortening heat in cardiac muscle and reveal, mechanistically, the source of this excess heat. Our results clarify a long‐standing uncertainty in the field of cardiac muscle energetics. We provide a revised partitioning of cardiac muscle energy expenditure to include this newly revealed thermal component.
Dihydrocyclam dimaleate [H2(cyclam)(maleate)2]

The asymmetric unit of the title molecular salt [systematic name: 1,4,8,11-tetraazacyclotetradecane-1,8-diium bis(3-carboxyprop-2-enoate)], C10H26N4 2+·2C4H3O4 −, contains two half-cations (both completed by crystallographic inversion symmetry) and two maleate anions. The cyclam macrocycles adopt trans-III conformations, supported by two intramolecular N—H⋯O hydrogen bonds. The O-bonded H atom of each maleate ion is disordered over two positions with an occupancy ratio of 0.61 (5):0.39 (5): each one generates an intramolecular O—H⋯O hydrogen bond. In the crystal, the cations are linked to the anions by N—H⋯O hydrogen bonds, generating [001] chains.
Simvastatin: a review

Simvastatin is a long-established hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, first introduced in 1988. At the maximal recommended dose of 80 mg/day, it produces an average reduction in low-density lipoprotein cholesterol (LDL-C) of 47%, accompanied by reductions in very LDL-C, triglycerides and apolipoprotein B, and a modest increase in high-density lipoprotein cholesterol. The only important, although rare, adverse effect of simvastatin is myopathy, an effect shared by all members of the class; when severe, this can take the form of rhabdomyolysis, which may lead to acute renal failure. The mechanism of the myopathy is not understood. The risk is increased by certain concomitant drugs, including gemfibrozil and potent inhibitors of cytochrome P450 3A4. Simvastatin has been studied in two large outcome trials, the Scandinavian Simvastatin Survival Study (4S), and the Heart Protection Study (HPS), both of which demonstrated strikingly beneficial effects on a variety of cardiovascular outcomes, with minimal adverse effects. 4S was the first study with a cholesterol-lowering agent to demonstrate an unequivocal reduction in all-cause mortality (30%; p = 0.0003). HPS showed that the beneficial effects of simvastatin were obtainable in a broad array of patients with, or at high risk of, coronary heart disease (CHD) in categories previously little studied, including women, the elderly, patients with diabetes without known CHD, and, perhaps most importantly, patients with LDL-C well below the UK population average. Simvastatin has recently become available in many countries as a combination product with the cholesterol absorption inhibitor, ezetimibe. Because of its long record of safety and demonstrated ability to reduce cardiovascular risk, simvastatin has recently become available without a prescription in the UK at the 10 mg dosage level.
REFERENT BODY WEIGHT VALUES IN OVER GROUND WALKING, OVER GROUND JOGGING, TREADMILL JOGGING, AND ELLIPTICAL EXERCISE

Background In order to make reliable clinical decisions in relation to when injured or surgically operated athletes may return to daily functional and weight-bearing sporting activities, there is a need to establish referent average weight-bearing values in common sporting activities. Objectives To evaluate average percentage body weight (APBW) values and weight-bearing distribution percentages (WBDP) between sports activities in a referent adult population, and to suggest clinical implications. Design Original research study. Setting Lerner Sports Center, Hebrew University, Mount Scopus, Jerusalem, Israel. Participants 75 asymptomatic volunteers, mean age=33.5(19–72) years SD=15.1, mean weight (kg)=70.7 (43–113) SD=14.1. Interventions 4 tests were conducted: 1. Overground walking (OGW) over a 20m distance, 2. Overground jogging (OGJ) over a 20m distance, 3.Treadmill jogging (TJ) at a constant speed of 8.5 km/hr for a 15-second interval and 4. Elliptical exercise (EE) for a 20 second period at a resistance and incline level of 10, and a steady pace within the range of 70–95 steps/min. Main outcome measure The Smartstep™ weight-bearing gait analysis system. Results The APBW value on the entire foot in OGW was 112% (SD=15.57), in OGJ, 201% (SD=31.24, in TJ, 175% (SD=25.48) and in EE, 73% (SD=13.8). Regarding WBDP, the swing phase in OGJ and TJ was significantly longer than the stance phase (P<.05). Conclusions EE significantly reduces weight-bearing as compared to other common functional and sporting activities. This information is also useful from a repetitive loading standpoint (to prevent overuse injury) or for exercise recommendations for those at greater risk for exacerbating chronic joint pathology.
Indoor navigation approach based on approximate positions

Until now navigation aids have primarily focused on outdoor scenarios, whether driving on highways or, more recently, walking through cities. These systems use the Global Positioning System (GPS) for position information. Indoor navigation however cannot rely on GPS data, as the signals do not penetrate building structure. Thus other techniques were developed to provide position information indoors, but most of them lack the precision of GPS. In this article the approach of an indoor navigation system based on imprecise position information is presented. To compensate the deficit of precision the position information is combined with a movement model. This movement model is automatically generated from the maps which are already required for navigation.
Speech Recognition in Noisy Environments with Convolutional Neural Networks

One of the biggest challenges in speech recognition today is its use on a daily basis, in which distortion and noise in the environment are present and hinder the recognition task. In the last thirty years, hundreds of methods for noise-robust recognition were proposed, each with its own advantages and disadvantages. In this paper, the use of convolutional neural networks (CNN) as acoustic models in automatic speech recognition systems (ASR) is proposed as an alternative to the classical recognition methods based on HMM without any noise-robust method applied. The experiment showed that the presented method reduces the equal error rate in word recognition tasks with additive noise.
Ethylene-Regulated Glutamate Dehydrogenase Fine-Tunes Metabolism during Anoxia-Reoxygenation1

Ethylene participates in the regulation of glutamate dehydrogenase genes during anoxia-reoxygenation and modulates metabolism by enhancing tricarboxylic acid cycle replenishment to aid recovery in Arabidopsis. Ethylene is an essential hormone in plants that is involved in low-oxygen and reoxygenation responses. As a key transcription factor in ethylene signaling, ETHYLENE INSENSITIVE3 (EIN3) activates targets that trigger various responses. However, most of these targets are still poorly characterized. Through analyses of our microarray data and the published Arabidopsis (Arabidopsis thaliana) EIN3 chromatin immunoprecipitation sequencing data set, we inferred the putative targets of EIN3 during anoxia-reoxygenation. Among them, GDH2, which encodes one subunit of glutamate dehydrogenase (GDH), was chosen for further studies for its role in tricarboxylic acid cycle replenishment. We demonstrated that both GDH1 and GDH2 are induced during anoxia and reoxygenation and that this induction is mediated via ethylene signaling. In addition, the results of enzymatic assays showed that the level of GDH during anoxia-reoxygenation decreased in the ethylene-insensitive mutants ein2-5 and ein3eil1. Global metabolite analysis indicated that the deamination activity of GDH might regenerate 2-oxoglutarate, which is a cosubstrate that facilitates the breakdown of alanine by alanine aminotransferase when reoxygenation occurs. Moreover, ineffective tricarboxylic acid cycle replenishment, disturbed carbohydrate metabolism, reduced phytosterol biosynthesis, and delayed energy regeneration were found in gdh1gdh2 and ethylene mutants during reoxygenation. Taken together, these data illustrate the essential role of EIN3-regulated GDH activity in metabolic adjustment during anoxia-reoxygenation.
Frequency agile mechanical antenna for low-cost millimeter-wave applications

This paper presents for the first time a frequency tunable, mechanical patch antenna on PDMS/LCP for low-cost millimeter-wave applications. A pneumatic actuation system controls the height of the antenna, resulting in an analog tuning in frequency. The antenna is fed with a typical microstrip line coupled through a slot aperture patterned in the ground plane at the back side of a liquid crystal polymer substrate where the antenna is bonded to. The proposed antenna has a measured gain of 8 dBi, a 10-dB bandwidth of 4.8 GHz at 61.75 GHz and a tuning frequency range of 450 MHz. The designed antenna can be easily scaled to fit other millimeter-wave frequency applications.
Derivation and validation of a prognostic model for workers disabled by depression

1 Nigar Sekercioglu1, Shaun Shaikh2, Gordon H. Guyatt3, Jason W. Busse1,4,5 1Department of Health Research Methods, Evidence, and Impact, McMaster University, 2Department of Economics, McMaster University, 3Department of Medicine, McMaster University, 4Department of Anesthesia, McMaster University, 5The Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada. PROGNOSTIC MODEL FOR WORKERS DISABLED BY DEPRESSION DERIVATION AND VALIDATION OF A PROGNOSTIC MODEL FOR WORKERS DISABLED BY DEPRESSION
Late Intervention on an Occluded Infarct-Related Artery: A Meta-analysis of the Randomized Controlled Trials

Context Late intervention to open an occluded infarct-related artery (IRA) after initial acute myocardial infarction was postulated to lead to clinical benefit. Objective To conduct a meta-analysis of the randomized trials. Study Selection Eligibility criteria were: 1) randomized trials comparing percutaneous coronary intervention (PCI) in a totally occluded artery (TIMI flow 0-1) versus medical therapy, 2) in stable post myocardial infarction (MI) patients without spontaneous or low level exercise induced ischemia, 3) trials with a time from the onset of symptoms to randomization >24 hours, but <6 weeks, and 4) trials reporting mortality and recurrent MI as an endpoint. Of 961 citations reviewed, 3 disagreements were easily resolved by discussion and 6 trials were selected for inclusion. Data Synthesis The primary endpoint was the composite of recurrent MI or death. The secondary endpoints were the development of heart failure or recurrent myocardial infarction. In a meta-analysis of the 6 trials, which included 2642 patients, late intervention of an IRA had a RR of death or recurrent MI of 1.12 (95% CI 0.91-1.38). Data regarding the development of heart failure was available for 4 trials. In a meta-analysis of these 4 trials, which included 2527 patients, late intervention of an IRA had a RR of 0.79 (95% CI 0.58-1.08). Data regarding the occurrence of recurrent MI was available for 5 trials. In a meta-analysis of these 5 trials, which included 2598 patients, late intervention of an IRA had a RR of 1.28 (95% CI 0.91-1.79). Conclusions Our meta-analysis of the currently available randomized data addressing late intervention of an occluded IRA failed to reveal clinical benefit with regard to the clinical endpoints of death, heart failure or reinfarction. The trend towards an increase in reinfarction among the PCI treated patients suggested by the Open Artery Trial (OAT) investigators persisted, but did not achieve statistical significance.