Miracle-dz/UniFAR-FTUs huggingface dataset:
Embedding simulation technologies in business processes.

The need to fully integrate simulation as a daily tool has been subject to much attention over the past few years, however little research has previously contributed to this area. This study examines the development of systematic guidelines to enable companies to strategically implement simulation as a mainstream technology within their businesses.An extensive review of the literature was conducted in order to investigate the reasons behind the limited use of simulation and to establish the failure and success factors of companies implementing new technology. The importance of knowledge management in developing simulation technology was also investigated. Additionally, a questionnaire survey was conducted to examine the ways in which simulation technology has been used and developed within different companies. Furthermore, a case study was conducted in order to understand and investigate the processes of implementing simulation in a real organisation.Subsequently, an easy-to-follow framework for enabling companies to embed simulation technologies into their business processes was developed. This framework comprises five key stages, namely: Foundation, Introduction, Infrastructure,Deployment and Embedding. Each stage provides a best practice approach to guide companies in achieving every objective of that stage. Adjustments to the framework were made in the validation and reliability section to reduce any limitations.In creating a relevant and workable framework, this study has contributed significantly to the research gap established within existing simulation integration studies.
PREDICTIVE MODELS OF THE ENERGY CONSUMPTION IN INTELLIGENT BUILDINGS

In this work we present a novel approach to energy saving in buildings through the identification of the relevant parameters and the application of Soft Computing techniques to generate predictive models of energy consumption in buildings. To verify the feasibility of this proposal, we apply our approach to a reference building for which we have contextual data from a complete year of monitoring. First, we characterize the building in terms of its contextual features and energy consumption, and then select the most appropriate techniques to generate the most accurate model of our reference building charged with estimating the energy consumption, given a concrete set of inputs.
The Use of Banking Products and Services by Low-Income and Under-Banked Consumers in the Nelson Mandela Bay

Financial inclusion provides recourse for consumers who do not have access to affordable basic financial products and services. Low-income and under-banked consumers face a myriad of factors that may prevent them from having effective access and use of banking products and services. The primary objective of this article was to investigate the factors affecting the use of banking products and services by low-income and under-banked consumers. A quantitative research approach was followed. A non-probability sample of 400 respondents was surveyed using self-administered questionnaires, yielding 307 usable questionnaires. An exploratory factor analysis was carried out to determine validity, and Cronbach’s alpha coefficients were calculated to determine reliability. Descriptive statistics were calculated to summarise the sample data, and the hypothesised relationships were assessed by means of a multiple regression analysis. The results revealed that of the five factors under investigation, two were found to be have a significant positive influence on the use of banking products and services, namely Financial awareness and Appropriateness. Based on the empirical results, recommendations were made to help improve the banking institutions’ ways of attracting and retaining low-income and under-banked consumers to use their products and services effectively.
A comprehensive analysis of the effect of microarray data

Background: Microarray data preprocessing, such as differentially expressed (DE) genes selection, is performed prior to higher level statistical analysis in order to account for technical variability. Preprocessing for the Affymetrix GeneChip includes background correction, normalisation and summarisation. Numerous preprocessing methods have been proposed with little consensus as to which is the most suitable. Furthermore, due to poor concordance among results from cross-platform analyses, protocols are being developed to enable cross-platform reproducibility. However, the effect of data analysis on a single platform is still unknown. The objective of our study is two-fold: first to determine whether there is consistency in the results obtained from a single platform; and second to investigate the effect of preprocessing on DE genes selection, analysed on four datasets. Results: Results indicate that microarray analysis is subjective. The lists of DE genes are variable and dependent on the preprocessing method used. Furthermore, the characteristics of the dataset, and the type of DE genes identification method used, greatly affect the outcome. Despite using a single platform, there is a lot of variability in the results. Conclusions: This is the first comprehensive analysis using multiple datasets generated from a single platform and involving many DE genes selection methods to assess the effect of data preprocessing on downstream analysis. Results indicate that preprocessing methods affect downstream analysis. Results are also affected by the kind of data and statistical analysis tools used. Our study reveals that there are inconsistencies in results obtained from a single platform. These issues have been overlooked in past reports. Type of Report: Other Department of Computer Science & Engineering Washington University in St. Louis Campus Box 1045 St. Louis, MO 63130 ph: (314) 935-6160 A comprehensive analysis of the effect of microarray data preprocessing methods on differentially expressed transcript
Heidelberg capsule. I. In vitro evaluation of a new instrument for measuring intragastric pH.

The current methods available for measuring gastric pH are briefly reviewed. These methods provide limitations ( a ) restricted to the fasting stomach, ( b ) may provide stimulation of acid secretion, and ( c ) involves considerable patient resistance. Telemetering equipment has provided important data on many physiological processes. A new device called the Heidelberg capsule has been proposed to telemeter gastric pH. The studies include ( a ) standardization of equipment, ( b ) in vitro evaluation of the accuracy and precision of the device, and ( c ) determination of in vitro life and drift of the capsule. The in vitro data justify further studies of the instrument for in vivo evaluation of intragastric pH. The Heidelberg capsule may represent an important tool for tubeless in vivo evaluation of antacids and possibly other drugs.
Neuroplasticity in the olfactory system: Differential effects of central and peripheral lesions of the primary olfactory pathway on the expression of B‐50/GAP43 and the olfactory marker protein

The regeneration of the olfactory neuroepithelium following olfactory bulbectomy or peripheral deafferentation was studied with mRNA probes and antibodies for B‐50/GAP43 and for olfactory marker protein (OMP). Two stages in the regeneration of the olfactory epithelium could be discerned with these reagents. The first stage occurs following either peripheral deafferentation of the olfactory epithelium with Triton X‐100 (TX‐100) or after bulbectomy and is characterized by the formation of a large population of immature olfactory receptor neurons. These newly formed neurons express B‐50/GAP43, a phosphoprotein related to neuronal growth and plasticity. During the second stage of the regeneration process the newly formed olfactory neurons mature, as evidenced by a decrease in their expression of B‐50/GAP43 and an increase in the expression of OMP. This stage is only manifested if the developing neurons have access to the target olfactory bulb. Formation of a full complement of OMP‐expressing neurons occurs only after peripheral lesion with TX‐100. In contrast, following bulbectomy the reconstituted olfactory epithelium lacks its normal target and is compromised in its ability to recover from nerve damage, as evidenced by the presence of a large number of B‐50/GAP43‐expressing neurons up to 3 months after the lesion and its failure to establish a full complement of OMP‐expressing neurons. These results demonstrate that the olfactory epithelium is capable of replacing its sensory neurons independently of the presence of its target, the olfactory bulb. However, the differential patterns of expression of B‐50/GAP43 and OMP at long times after peripheral lesion with TX‐100 or bulbectomy illustrate the profound effect the olfactory bulb has on neuronal maturation in reconstituted olfactory neuroepithelium.
A Hybrid Lagrangian-Eulerian Approach for Two-Phase Flows with Fully Resolved Interfaces

A hybrid Lagrangian-Eulerian (hLE) scheme, combining a particle-based, mesh-free technique with a finitevolume flow solver, is developed for direct simulations of two-phase flows. This approach merges the naturally adaptive nature of particle-based schemes, for ecient representation of the interface between two media, with the relative flexibility oered by grid-based solvers for complex flows. A mesh-free, particle-based scheme for interface tracking (Hieber & Koumoutsakos 2005) is first integrated with a co-located grid based finite volume solver. A balanced force algorithm (Francois et al. 2006, Herrmann 2006), for accurate representation of surface tension forces, is used to solve the two-phase flow equations on a fixed background mesh. The accuracy of the particle-based scheme is first verified for standard test cases on interface tracking. The hybrid scheme is then applied to perform coupled two-phase flow simulations of stationary drop and rising bubbles.
Array CGH in molecular diagnosis of mental retardation—A study of 150 Finnish patients

We report on the results of an array comparative genomic hybridization (array CGH) study of 150 karyotypically normal Finnish patients with idiopathic mental retardation and/or dysmorphic features and/or malformations. Using high‐resolution microarray analysis, we sought to identify clinically relevant microdeletions and microduplications in these patients. The results were confirmed using other methods and compared with findings reported in recent publications and internet databases. Small aberrations of potential clinical significance were found in 28 (18.6%) of the 150 patients. Eight of the identified aberrations are known to cause syndromes, 4 affected the X chromosome in males, 4 were familial, and 13 have yet to be associated with a phenotype. This study demonstrates the benefits of array CGH in clinical diagnostics of developmental disorders. Further, our findings give evidence of new syndromes. © 2010 Wiley‐Liss, Inc.
[Comparison of two approaches for the treatment of supracondylar fractures in children by K-wires].

OBJECTIVE To explore the clinical effect between two approaches for the treatment of supracondylar fractures of humerus by K-wires in children. METHODS From Jan. 2004 to Dec. 2006,117 children with supracondylar fractures of humerus were divided into two groups according to different methods of the K-wires fixation involving two K-wires group and three K-wires group. In two K-wires groups,there were 45 children including 31 boys and 14 girls with an average age of 5.6 years ranging from 1 to 11 years; according to Garland classification, 19 cases were type II, 26 cases were type III. In three K-wires groups, there were 72 children including 47 boys and 25 girls with an average age of 6.8 years ranging from 2 to 12 years; according to Garland classification, 22 cases were type II, 50 cases were type II. The movement and carrying angle of elbow joint were measured for all these patients. According to Flynn criteria for supracondylar fracture the results of two approaches with K-wires were compared. RESULTS All patients were followed-up from 2 to 24 months (means 15.4 months). In two K-wires group, the results of Flynn were excellent in 27 cases, good in 12 cases, fair in 4 cases and poor in 2 cases, 41 cases gained bony healing, however, fail of fixation arosed in 4 cases and cubitus varus arosed in 2 cases. In three K-wires group, the results of Flynn were excellent in 60 cases, good in 11 cases and poor in 1 case, all cases of three K-wires group achieved bony healing after 6 weeks of operation, the function of joints recovered through exercise and cubitus varus arosed in one case after operation. CONCLUSION The technique of fixation with K-wires is a stable and reliable methods for unstable supracondylar fracture but medial-lateral three-pin fixation is better than one with two pins.
Evaluation of porphyria

The porphyrias are relatively uncommon disorders that most dermatologists treat from time to time. Evaluating a patient with porphyria may seem daunting to those not familiar with the nuances of these disorders. This brief account provides a summary of the main aspects of porphyria that should be considered in each patient. Genetic defects and pathophysiology are steadily being delineated, treatments are now more appropriate and genetic counselling more accurate.
Risk of Suicide in Adolescents with Symptoms of Eating Disorders and Depression

Objective: The aim of the present study was to determine the risk of suicide in adolescents with symptoms of eating disorders and depression. Methods: A population-based, cross-sectional study was conducted with 1379 students of public schools aged 10 to 17 years. The following evaluation tools were employed: A socio-demographic questionnaire, Eating Attitudes Test (EAT-26), Bulimic Investigatory Test of Edinburgh (BITE), Children’s depression inventory (CDI) and the Mini International Neuropsychiatric Interview (M.I.N.I. – Brazilian version 5.0.0). Data analysis involved one-dimensional and two-dimensional tables with absolute and relative frequencies as well as the calculation of odds ratios (OR) and respective 95% confidence intervals associated with the levels described using Pearson’s chi-square test. In the multivariate analysis, a binary logistic regression model was adjusted, including variables with a p-value <0.05 in the binary analysis as possible explanatory variables. Results: Through the ORs, it was estimated that the probability of an adolescent in the population analysed of being at risk of suicide was higher when the adolescent was older than 11 years, of the female gender, had symptoms of an eating disorder and had depressive symptoms. Conclusion: The risk of suicide is not restricted to clinical samples of adolescents with eating disorders, but can also be detected in non-clinical samples. Moreover, the risk is higher among adolescents with symptoms of both eating disorders and depression.
Immersion of rohu fingerlings in clove oil reduced handling and confinement stress and mortality

The use of anaesthetics becomes essential in the transportation medium for mitigating physiological stress and reducing metabolic rates. Clove oil is now emerging as safe, eco-friendly, effective, and economic fish anaesthetic. We tested the efficacy of clove oil as an anaesthetic for the handling and transportation of rohu, Labeo rohita (Hamilton-Buchnan) fingerlings. The lowest effective dose of clove oil that produced induction (≤3 min) and recovery (≤5 min) found was 50µl L -1 . The induction times decreased and recovery times increased with increased in the concentrations of clove oil. The effective sedative dose at 5µl L -1 of clove oil was found suitable for transportation in plastic bags with pure oxygen up to 12h. The mortality rate (%) of fingerlings was significantly higher (14.4±1.14%) in the control (without sedative) than sedative doses of clove oil (P<0.05). The dose at 5µl L -1 of clove oil was found to mitigate stress responses with lower glucose level and reduce the deterioration of water quality in comparison to control. The present findings revealed that clove oil is promising to be used as anaesthetic and sedative for handling and transportation of rohu fingerlings. Clove oil is feasible to use in the commercial fish seed transportation due its merits like cheap and safe anaesthetic.
Surround modulation in cortical orientation map revealed by optical imaging and its dependency on receptive field eccentricity

Optical imaging was used to investigate the difference in surround modulation on orientation map related to receptive field eccentricity in cat visual cortex. Presentation of center–surround stimuli at the center of gaze resulted in no clear surround modulation; however, significant modulation was observed in its corresponding cortical area when the center–surround stimuli were presented at 10° eccentricity in more peripheral parts of the visual field. Modulation was observed both in the response magnitude and in the spatial pattern of the response. Surround orientation perpendicular to the orientation of a center patch grating showed the largest modulation in the response magnitude. The modulation became weaker as the orientation difference between the center and surround gratings became smaller. Regardless of the orientations for the central patch gratings, a similar response spatial pattern was observed in the cortical region where the underlying cells had their receptive fields covering the central patch, if the stimuli were with the same surround gratings. These properties support the notion of a relative specialization for visual information processing in peripheral representations of cortical areas.
A New Wireless Sensor Used in Grain Pests Detection

At present, there are many detection methods of the grain pest, but these detection methods have many defects, such as low efficiency, poor accuracy, great implementation difficulty, detection not in time, etc. To solve the above defects, this paper provides a wireless sensor which can detect the species and quantity of the grain pest at the same time. Its main principle is: when pests go through detection electrodes of the sensor, its capacitance value will change. Due to different species of the grain pests have different dielectric constant, then, the change range is also different. According to different capacitance value range, the capacitance detection circuit determines the species of pests, and records the changing times of capacitance to determine the quantity of grain pests. The sensor has the advantages of the low power and the wireless transmission of the detection data and so on, and is suitable for large range of promotion. This has great significance on the China's grain safety.
A domain independent Genetic Programming approach to automatic feature extraction for image classification

In this paper we explore the application of Genetic Programming (GP) to the problem of domain-independent image feature extraction and classification. We propose a new GP-based image classification system that extracts image features autonomously, and compare its performance against a baseline GP-based classifier system that uses human-extracted features. We found that the proposed system has a similar performance to the baseline system, and that GP is capable of evolving a single program that can both extract useful features and use those features to classify an image.
Raman and IR study on copper binding of histamine.

A comparative Raman and FTIR study of histamine (Hm), a small hormone present in a wide selection of living organisms, and its complexes with copper(II) at different pH values was carried out. Both the Raman and IR spectra present some marker bands useful for the identification of the structure of the species predominating in the Cu(II) aqueous and alcoholic systems. In particular, Raman spectroscopy appears to be a useful tool for analyzing the tautomeric equilibrium of the imidazole ring of Hm, because some bands (i.e., nuC(4)dbond;C(5)) appear at different wavenumbers, depending on whether the imidazole moiety is in the N(tau)-H (tautomer I) or N(pi)-H (tautomer II) protonated form. In aqueous solutions the manner in which Hm binds to Cu(II) depends on the pH. At basic pH the most relevant species formed are a dimer, [Cu(2)L(2)H(-2)](2+), and a monomeric complex, [CuL](2-) or [CuL(2)](+). On the contrary, by decreasing the pH, Hm acts as a mono- or bidentate ligand, giving rise to two types of monomeric complexes, [CuLH](2-) and [CuL](2-) or [CuL(2)](+). With respect to the Cu(II)-Hm alcoholic system, both the aminic group and the imidazole ring (tautomer I) take part in the Cu(II) coordination, leading to the formation of the [CuL](2-) or [CuL(2)](+) monomeric complex.
Design and simulation equivalent model of Floating Gate Transistor

The first Floating Gate Transistor (metal-insulator-metal-insulator structure) was proposed by Kahng and Sze in 1967 [1]. Using the floating gate voltage value, capacitive coupling coefficients can be found out at different bias conditions as required. Once these have been found out for a particular technology, the values of the capacitances can be found out and implemented in the given model. The charge present on the gate has to be calculated using the transient models of hot electron programming and Fowler nordheim tunneling. These can be incorporated and thus the model can be extended to the transient conditions as well. The SPICE equivalent model is designed and Current Voltage characteristics and Transfer characteristics are comparatively analyzed.
Real-Time Glucose Estimation Algorithm for Continuous Glucose Monitoring Using Autoregressive Models

Background: Continuous glucose monitors (CGMs) present a problem of lack of accuracy, especially in the lower range, sometimes leading to missed or false hypoglycemia. A new algorithm is presented here aimed at improving the measurement accuracy and hypoglycemia detection. Its core is the estimation of blood glucose (BG) in real time (RT) from CGM intensity readings using autoregressive (AR) models. Methods: Eighteen patients with type 1 diabetes were monitored for three days (one at the hospital and two at home) using the CGMS® Gold. For these patients, BG samples were taken every 15 min for 2 h after meals and every half hour otherwise during the first day. The relationship between the current measured by the CGMS Gold and BG was learned by an AR model, allowing its RT estimation. New capillary glucose measurements were used to correct the model BG estimations. Results: A total of 563 paired points were obtained from BG and monitor readings to validate the new algorithm. 98.5% of paired points fell in zones A+B of the Clarke error grid analysis with the proposed algorithm. The overall mean and median relative absolute differences (RADs) were 9.6% and 6.7%. Measurements meeting International Organization for Standardization (ISO) criteria were 88.7%. In the hypoglycemic range, the mean and median RADs were 8.1% and 6.0%, and measurements meeting ISO criteria were 86.7%. The sensitivity and specificity with respect to hypoglycemia detection were 91.5% and 95.0%. Conclusions: The performance measured with both clinical and numerical accuracy metrics illustrates the improved accuracy of the proposed algorithm compared with values presented in the literature. A significant improvement in hypoglycemia detection was also observed.
Building an associative memory vastly larger than the brain.

Prevalence of herpesvirus-like sequence in Kaposi's sarcoma (KS) tissue and blood of KS patients. Studies were conducted as described in text (2). Some of the tumor tissues and corresponding controls were provided by the University of California AIDS Specimen Bank under the direction of Dr. John Greenspan. Peripheral blood mononuclear cells from normal subjects came from healthy volunteers in the laboratory or were provided by Irwin Memorial Blood Centers, San Francisco, California.