Miracle-dz/UniFAR-FTUs huggingface dataset:
Osseointegration

Nowadays dental implants have become an important part of patient management, and the treatment of choice in many dental reconstructive cases. The history of implant, its composition, diff erent materials used for its manufacturing is still in a dilemma. This article describes titanium its historical background, diff erent types of implants used before. Per Ingvar Brånemark was the fi rst person who introduced the concept osseointegration. The aim of this paper is to make the clinician aware of the implant designs, materials for predictable success for rehabilitation of many clinical situations.
SOME PSYCHOPATHOLOGICAL PECULIARITIES AT EARLY AND LATE ONSET IN PATIENTS WITH ALZHEIMER'S DISEASE

SUMMARY: Age-related conditions are of great medical and social importance. The most common cause of dementia is Alzheimer’s disease (AD). Neuropsychiatric symptoms are an integral part of the disease and present severe problems to patients, their families, caregivers and the society at large. The aim of our work was to explore the manifestation of some psychic (non-psychotic and psychotic) and behavioral symptoms (BPSD) of hospitalized patients with early onset (EO-AD) and late onset (LO-AD) of AD with a view to compare and enrich the clinical, diagnostic and differential diagnostic possibilities. In this study significant differences in terms of BPSD between EO-AD and LO-AD patients were found. The data of EO-AD patients to be more psychotic with more behavioral problems could represent another clinical support of dividing AD not only to the age of onset. As we discuss in our paper some methodological issues, the number of examined patients in our study was comparatively small. That is why we comment some of the data as a tendency.
The Relationship between Caseworkers and Unemployed Workers

In recent years, caseworkers in job centers in Denmark have systematically assessed unemployed workers on multiple dimensions such as search behavior, skill level, health status, motivation, and job-readiness. In this paper, we merge these subjective measures with rich administrative register data and linked employer-employee data. We use this uniquely rich information set on the full population of unemployed to evaluate the effects of the different components of the active labor market programs. The focus of our study is to investigate the importance of the information available in the caseworker data when relying on conditional independence as the identifying assumption. Our paper contributes to the growing and empirically very important literature analyzing the value added from different data sources including novel caseworker information. JEL classification: J68, D04
Wireless Body Area Networks for Healthcare Applications: Protocol Stack Review

Wireless Body Area Networks (WBANs) supporting healthcare applications are in early development stage but offer valuable contributions at monitoring, diagnostic, or therapeutic levels. They cover real-time medical information gathering obtained from different sensors with secure data communication and low power consumption. As a consequence of the increasing interest in the application of this type of networks, several articles dealing with different aspects of such systems have been published recently. In this paper, we compile and compare technologies and protocols published in the most recent researches, seeking WBAN issues for medical monitoring purposes to select the most useful solutions for this area of networking. The most important features under consideration in our analysis include wireless communication protocols, frequency bands, data bandwidth, transmission distance, encryption, authentication methods, power consumption, and mobility. Our study demonstrates that some characteristics of surveyed protocols are very useful to medical appliances and patients in a WBAN domain.
Leadership Involvement in Preventing the Misuse of the Government Travel Charge Card

OF THE THESIS LEADERSHIP INVOLVEMENT IN PREVENTING THE MISUSE OF THE GOVERNMENT TRAVEL CHARGE CARD by Donald Richard Kaipo Bal Jr. American Public University System, June 28, 2015 Charles Town, West Virginia Professor Christi Bartman, Thesis Professor The research paper examines the misuse of the Government Travel Charge Card (GTCC) Program in the military and the lack of leadership involvement in the GTCC process. One area of concern is that military leaders are not taking proactive steps to mitigate the problem. Research of multiple Inspector General Reports from various government agencies were used to determine if leadership involvement was evident. Leadership culpability was analyzed under the context of both leadership and ethical theories. More specifically, the research focused on transformational and transactional leadership theories in addition to utilitarian and deontological theories, which drew a more comprehensive picture of why leaders are not involved in the process and how they could employ these theories to become more proactive leaders in managing the process. The results indicated that proactive leadership would aid in mitigating the issue and that the combination of both leadership theories will enhance the leader’s ability to combat GTCC misuse in addition to fostering good ethical conduct within their organizations. LEADERSHIP INVOLVEMENT 6
myDeal: a mobile shopping assistant matching user preferences to promotions

A common problem in large urban cities is the huge number of retail options available. In response, a number of shopping assistance applications have been created for mobile phones. However, these applications mostly allow users to know where stores are or find promotions on specific items. What is missing is a system that factors in a user's shopping preferences and automatically tells them which stores are of their interest. The key challenge in this system is twofold; 1) building a matching algorithm that can combine user preferences with fairly unstructured deals and store information to generate a final rank ordered list, and 2) designing a mobile application that can capture user preferences and display deal information to the user in an intuitive way. In this paper, we present myDeal, a system that automatically ranks deals according to user preferences and presents them to the user on their mobile device.
High levels of synthesis and local effects of nerve growth factor in the septal region of the adult rat brain

NGF found in the basal forebrain is believed to be localized to NGF- dependent cholinergic neurons and derived via retrograde axonal transport from NGF-synthesizing target hippocampal and cortical neurons. The basis for this concept of target-derived NGF is the detection of only limited amounts of NGF mRNA in the basal forebrain, despite relatively high NGF levels there. Our work, using a more sensitive and quantitative RNase protection method for detecting relative NGF mRNA levels, suggested, instead, relatively high levels of NGF mRNA synthesis in the septal region of the basal forebrain (BF-S), a region which contained primarily cells that project to the hippocampus. Similar results were obtained in analyses of a larger portion of the basal forebrain, designated “BF,” that encompassed cholinergic neurons that project to both the hippocampus and the cortex. The level of NGF mRNA measured in both BF-S and BF was equivalent to approximately 50% of the amount observed in the hippocampus. Furthermore, relative NGF mRNA levels detected in the BF- S, cortex, and hippocampus were shown to be proportional to NGF protein levels quantitated in each region. The detection of relatively high amounts of NGF synthesis in the BF-S was supported in studies demonstrating rapid NGF receptor (Trk) activation in the basal forebrain by exogenous NGF and in experiments showing that NGF mRNA was inducible in the BF-S by 1,25 dihydroxyvitamin D3. The extent of NGF mRNA induction was similar (approximately twofold) in the BF-S, hippocampus, and cortex, suggesting similar regulatory mechanisms. (ABSTRACT TRUNCATED AT 250 WORDS)
Antineutrophil cytoplasmic antibody negative pauci‐immune extracapillary glomerulonephritis

Pauci‐immune extracapillary glomerulonephritis (PEGN) is one of the most common causes of rapidly progressive glomerulonephritis and is usually associated with circulating anti‐neutrophil cytoplasmic antibodies (ANCAs). However, a significant number of individuals with PEGN test negative for ANCA and this study aimed to analyze the characteristics of this subgroup of patients.
Comparative evaluation of two rapid Salmonella-IgM tests and blood culture in the diagnosis of enteric fever

Purpose: Enteric fever is a major public health problem in developing countries like India. An early and accurate diagnosis is necessary for a prompt and effective treatment. We have evaluated the diagnostic accuracy of two Rapid Salmonella-IgM tests (Typhidot-IgM and Enteroscreen-IgM) as compared to blood culture in rapid and early diagnosis of enteric fever. Materials and Methods: A total of 2,699 patients′ serum samples were tested by Rapid Salmonella-IgM tests and blood culture. Patients were divided into two groups. Test group - patients with enteric fever and blood culture positives for Salmonella Typhi; and three types of Controls, i.e. patients with non-enteric fever illnesses, normal healthy controls and patients positive for S. Paratyphi- A. In addition to this we have also evaluated the significance of positive Salmonella-IgM tests among blood culture-negative cases. Results: The overall sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the Typhidot-IgM test and Enteroscreen-IgM test considering blood culture as gold standard were 97.29% and 88.13%, 97.40% and 87.83%, 98.18% and 92.03%, 96.15% and 82.27%, respectively. Typhidot-IgM test was found to be significantly more sensitive and specific as compared to Enteroscreen-IgM. Among blood culture-negative patients, Rapid Salmonella-IgM tests detected 72.25% additional cases of enteric fever. Although the Rapid Salmonella-IgM tests are meant to diagnose S. Typhi only, but these tests detect S. Paratyphi- A also. Thirty-eight patients who were blood culture-positive for S. Paratyphi- A were also positive by Rapid Salmonella-IgM tests. Conclusion: Rapid Salmonella-IgM tests offer an advantage of increased sensitivity, rapidity, early diagnosis and simplicity over blood culture.
Cloning and Characterization of the Glycoside Hydrolases That Remove Xylosyl Groups from 7-β-xylosyl-10-deacetyltaxol and Its Analogues*

Paclitaxel, a natural antitumor compound, is produced by yew trees at very low concentrations, causing a worldwide shortage of this important anticancer medicine. These plants also produce significant amounts of 7-β-xylosyl-10-deacetyltaxol, which can be bio-converted into 10-deacetyltaxol for the semi-synthesis of paclitaxel. Some microorganisms can convert 7-β-xylosyl-10-deacetyltaxol into 10-deacetyltaxol, but the bioconversion yield needs to be drastically improved for industrial applications. In addition, the related β-xylosidases of these organisms have not yet been defined. We set out to discover an efficient enzyme for 10-deacetyltaxol production. By combining the de novo sequencing of β-xylosidase isolated from Lentinula edodes with RT-PCR and the rapid amplification of cDNA ends, we cloned two cDNA variants, Lxyl-p1–1 and Lxyl-p1–2, which were previously unknown at the gene and protein levels. Both variants encode a specific bifunctional β-d-xylosidase/β-d-glucosidase with an identical ORF length of 2412 bp (97% identity). The enzymes were characterized, and their 3.6-kb genomic DNAs (G-Lxyl-p1–1, G-Lxyl-p1–2), each harboring 18 introns, were also obtained. Putative substrate binding motifs, the catalytic nucleophile, the catalytic acid/base, and potential N-glycosylation sites of the enzymes were predicted. Kinetic analysis of both enzymes showed kcat/Km of up to 1.07 s−1mm−1 against 7-β-xylosyl-10-deacetyltaxol. Importantly, at substrate concentrations of up to 10 mg/ml (oversaturated), the engineered yeast could still robustly convert 7-β-xylosyl-10-deacetyltaxol into 10-deacetyltaxol with a conversion rate of over 85% and a highest yield of 8.42 mg/ml within 24 h, which is much higher than those reported previously. Therefore, our discovery might lead to significant progress in the development of new 7-β-xylosyl-10-deacetyltaxol-converting enzymes for more efficient use of 7-β-xylosyltaxanes to semi-synthesize paclitaxel and its analogues. This work also might lead to further studies on how these enzymes act on 7-β-xylosyltaxanes and contribute to the growing database of glycoside hydrolases.
Factors associated with bullying at nurses ’ workplaces 1

Objective: To identify nurses who are subject to workplace bullying and its associated factors. Method: Descriptive and exploratory study with a quantitative approach. The sample consisted of 199 nurses working in public and private sectors (N=388). For data collection, a graphic socio-professional questionnaire and the Leymann Inventory Psychological Terrorization were used, both in print or electronic format (May/September 2010). Results: According to the data collected, 11.56% of the participants had been subject to bullying. Multivariate analysis showed that having children, working at Public Healthcare Units, working at an institution for a period between one and three years, currently dealing with acts of bullying and to feel bullied are risk factors for bullying. Conclusion: This study permitted a better understanding of the factors associated with bullying; however, a research based on samples of Brazilian nurses is only the first step to evaluate other factors of influence related to the organizational context.
Combination Levothyroxine + Liothyronine Treatment in Pregnancy

Hypothyroidism is one of the most common endocrine disorders in young women and affects 3% to 4% of all pregnancies. Inadequately treated maternal hypothyroidism is associated with numerous adverse fetal and maternal outcomes. Because of growing popularity of levothyroxine (L-T4) + liothyronine (L-T3) combination therapy for hypothyroidism in nonpregnant individuals, pregnant women are taking these medications with increasing frequency. This article reviews the theoretical dangers of combination L-T4 + L-T3 treatment during pregnancy by outlining physiological regulation of maternal and fetal thyroid homeostasis, proposed adverse fetal outcomes to combination therapy, and current recommendations on thyroid replacement in pregnancy from professional societies. Target Audience Obstetricians and gynecologists, family physicians Learning Objectives After participating in this activity, physicians should be better able to discuss maternal-fetal transfer of thyroid hormone, indications for combination L-T4 + L-T3 treatment in nonpregnant individuals, and potential maternal and fetal consequences of L-T4 + L-T3 therapy during pregnancy.
Iron Particles for Noninvasive Monitoring of Bone Marrow Stromal Cell Engraftment into, and Isolation of Viable Engrafted Donor Cells from, the Heart

Stem cells offer a promising approach to the treatment of myocardial infarction and prevention of heart failure. We have used iron labeling of bone marrow stromal cells (BMSCs) to noninvasively track cell location in the infarcted rat heart over 16 weeks using cine‐magnetic resonance imaging (cine‐MRI) and to isolate the BMSCs from the grafted hearts using the magnetic properties of the donor cells. BMSCs were isolated from rat bone marrow, characterized by flow cytometry, transduced with lentiviral vectors expressing green fluorescent protein (GFP), and labeled with iron particles. BMSCs were injected into the infarct periphery immediately following coronary artery ligation, and rat hearts were imaged at 1, 4, 10, and 16 weeks postinfarction. Signal voids caused by the iron particles in the BMSCs were detected in all rats at all time points. In mildly infarcted hearts, the volume of the signal void decreased over the 16 weeks, whereas the signal void volume did not decrease significantly in severely infarcted hearts. High‐resolution three‐dimensional magnetic resonance (MR) microscopy identified hypointense regions at the same position as in vivo. Donor cells containing iron particles and expressing GFP were identified in MR‐targeted heart sections after magnetic cell separation from digested hearts. In conclusion, MRI can be used to track cells labeled with iron particles in damaged tissue for at least 16 weeks after injection and to guide tissue sectioning by accurately identifying regions of cell engraftment. The magnetic properties of the iron‐labeled donor cells can be used for their isolation from host tissue to enable further characterization.
Impact of Lock-in Period Expiration on Share Prices and Volume: An Empirical Study

This paper examines the impact of lock-in period expiration on share prices and stock volume using closing prices and volume of BSE index for the period of 21 and 11 days around the event. The sample consists of one sixty five events of lock-in period expiration during seven year period i.e. from 2003 to 2009 for the IPOs which came in the year 2000 to 2006. The methods used include Standard event study, Market Adjusted Model, and Field and Hanka Model. The study provides evidence that the event of lock-in period expiration has not produced much impact on Indian stock market because results for both the methods of price reaction and for the method of stock volume reaction are insignificant which means share prices and stock volume of Indian companies have not faced any abnormality around the lock-in period expiration date.
Association of Keratinized Mucosa and Periimplant Soft Tissue Stability Around Implants With Platform Switching

Purpose:To investigate the influence of the width of keratinized mucosa (KM) on clinical parameters around dental implants with platform switching. Methods:One hundred eighteen patients with 320 implants participated in the evaluation. The width of KM, modified sulcus bleeding index (mBI), plaque index (PLI), mucosal recession (MR), and the compliance to the implant maintenance therapy (IMT) were evaluated. Results:A wide band of KM (KM width ≥ 2 mm) was associated with a significant lower mBI (0.12 ± 0.37; P < 0.0001), PLI (0.45 ± 0.56; P = 0.001), and less MR (0.06 ± 0.23; P < 0.0001) than a narrow band of KM (KM width < 2 mm) (Papilla Bleeding Index [PBI], 0.39 ± 0.60; PLI, 0.69 ± 0.63; MR, 0.27 ± 0.44). By “regular” and “irregular” IMT, a statistically significant difference was found between wide and narrow width of KM, for the mBI (wide vs narrow; 0.11 ± 0.31 vs 0.31 ± 0.52, P = 0.004 and 0.14 ± 0.45 vs 0.49 ± 0.69, P = 0.002, respectively). Conclusion:Absence of keratinized mucosa was associated with significant higher PLI, mBI, and MR. The IMT does not reject the protective role of KM against inflammation.
Energy Barrier Model of SRAM for Improved Energy and Error Rates

We propose an energy barrier model of Static Random Access Memory (SRAM). The model provides useful insights about memory error rates for write, read, and retention. We introduce the concept of intrinsic energy margin induced write failure. The proposed model is employed for evaluating various write and read assist mechanisms and their potential in modulating the memory failures. Our analysis reveals that this model is very effective in predicting the behavior of SRAM stability and can be used as a tool to expedite the early phases of design to build assist circuits. Additionally, it can also be used to optimize energy dissipation of SRAM cache.
Body mass index and injury risk among US children 9–15 years old in motor vehicle crashes

Objective: To determine the relationship between body mass index (BMI) and injury risk among US children in motor vehicle crashes. Design: Cross-sectional study using data from the Partners for Child Passenger Safety study, a child-focused crash surveillance system. Participants: A probability sample of children, 9–15 years of age, involved in crashes in parent-operated vehicles between 1 December 2000 and 31 December 2006. Main outcome measure: The odds ratio of Abbreviated Injury Severity (AIS) 2+ injuries (overall and body region specific) by BMI category: underweight, normal, overweight, and obese. Results: The study sample included 3232 children in 2873 vehicles, representing a population estimate of 54 616 children in 49 037 vehicles. Approximately 15% (n = 502) sustained an AIS 2+ injury to any body region; 34% of the children were overweight or obese. There was no overall increase in injury risk by BMI; however, body region differences were found. In multivariate logistic regression, compared with normal weight children, the odds of sustaining an AIS 2+ injury to the extremities for overweight and obese children was 2.64 (95% CI 1.64 to 4.77) and 2.54 (95% CI 1.15 to 5.59), respectively. Conclusions: Although overweight and obese children are not at increased overall risk of injury, they are at increased risk of injury to the lower and upper extremities. This increased risk may be due to a combination of physiology, biomechanical forces, and vehicle design.
Environment‐Adaptive Contact Poses for Virtual Characters

We present a novel method to generate a virtual character's multi‐contact poses adaptive to the various shapes of the environment. Given the user‐specified center of mass (CoM) position and direction as inputs, our method finds the potential contacts for the character in the surrounding geometry of the environment and generates a set of stable poses that are contact‐rich. Major contributions of the work are in efficiently finding admissible support points for the target environment by precomputing candidate support points from a human pose database, and in automatically generating interactive poses that can maintain stable equilibrium. We develop the concept of support complexity to scale the set of precomputed support points by the geometric complexity of the environment. We demonstrate the effectiveness of our method by creating contact poses for various test cases of environments.
"Brazilian Entrepreneurship Education Training: Risk, Innovativeness, and Achievement"

This study assessed propensity toward risk, innovativeness, and need for achievement in two groups (total n = 111) of Brazilian participants in an entrepreneurial and managerial training program. The Treatment Group (n = 57) was composed of practicing entrepreneurs, and micro and small business managers who had undergone entrepreneurial training. The Comparison Group (n = 54) was composed of individuals who had not undergone entrepreneurial training. Attitudes and behavior of both groups were assessed using standardized, pre-formatted bipolar responses scales. Statistical differences between the two groups were not significant and indicated their low propensity toward risk and need for achievement. Further, although the subjects revealed innovative tendencies, innovativeness was not business-oriented. The authors make three recommendations for future research. The first is to measure effectiveness of entrepreneurship education and training programs through longitudinal analysis, a need regularly mentioned in the literature with respect to any training activity. Second, considering that entrepreneurial micro and small businesses represent about 50% of the GDP in Brazil, future entrepreneurship education and training programs concentrate on these types of businesses, and develop proper educational tools and adequate, pertinent literature. Third, the specific contribution to the regional and national economies made by micro firms, self-employed individuals, and entrepreneurs should be investigated to help find individuals with characteristics inclined to enable them to deal with innovation and risk.