Miracle-dz/UniFAR-FTUs huggingface dataset:
Electrogenic malate uptake and improved growth energetics of the malolactic bacterium Leuconostoc oenos grown on glucose-malate mixtures

Growth of the malolactic bacterium Leuconostoc oenos was improved with respect to both the specific growth rate and the biomass yield during the fermentation of glucose-malate mixtures as compared with those in media lacking malate. Such a finding indicates that the malolactic reaction contributed to the energy budget of the bacterium, suggesting that growth is energy limited in the absence of malate. An energetic yield (YATP) of 9.5 g of biomass.mol ATP-1 was found during growth on glucose with an ATP production by substrate-level phosphorylation of 1.2 mol of ATP.mol of glucose-1. During the period of mixed-substrate catabolism, an apparent YATP of 17.7 was observed, indicating a mixotrophy-associated ATP production of 2.2 mol of ATP.mol of glucose-1, or more correctly an energy gain of 0.28 mol of ATP.mol of malate-1, representing proton translocation flux from the cytoplasm to the exterior of 0.56 or 0.84 H+. mol of malate-1(depending on the H+/ATP stoichiometry). The growth-stimulating effect of malate was attributed to chemiosmotic transport mechanisms rather than proton consumption by the malolactic enzyme. Lactate efflux was by electroneutral lactate -/H+ symport having a constant stoichiometry, while malate uptake was predominantly by a malate -/H+ symport, though a low-affinity malate- uniport was also implicated. The measured electrical component (delta psi) of the proton motive force was altered, passing from -30 to -60 mV because of this translocation of dissociated organic acids when malolactic fermentation occurred.
A Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis

Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology, and up to 20% of patients on dialysis have been diagnosed with it. Here we show that a large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion-channel protein transient receptor potential cation channel 6 (TRPC6). The proline-to-glutamine substitution at position 112, which occurs in a highly conserved region of the protein, enhances TRPC6-mediated calcium signals in response to agonists such as angiotensin II and appears to alter the intracellular distribution of TRPC6 protein. Previous work has emphasized the importance of cytoskeletal and structural proteins in proteinuric kidney diseases. Our findings suggest an alternative mechanism for the pathogenesis of glomerular disease.
HIERARCHICAL AND PARTITIONING ALGORITHM FOR DOCUMENT CLUSTRING : A SURVEY

Document clustering is the widely researched area because of large amount of rich and dynamic information are available in world wide web. It is the application of cluster analysis to texual documents. There are different applications of document clustering include automatic document organization, data mining , topic extraction and filtering or fast information retrieval. The purpose of this survey is to provide a review of different partitioning and hierarchical techniques used in documentclustering. KeywordsDocument clustering, Hierarchical clustering, Partitioning clustering, k-means.
Femoroacetabular impingement: can the alpha angle be estimated?

OBJECTIVE Femoroacetabular impingement is an important entity with well-described radiographic findings. One of the criteria of the cam type of femoroacetabular impingement is femoral head-neck dysplasia, denoted mathematically as the "alpha angle. " Several observers have reported that direct measurement of the angle may not be necessary because subjective appraisal may yield similar results. We sought to scientifically determine the accuracy of a subjective assessment, using the calculated angle as the gold standard. MATERIALS AND METHODS At 1.5 T, 50 consecutive patients' hips were evaluated on sets of oblique axial images. Two musculoskeletal radiologists recorded their subjective opinion as to the alpha angle using a confidence scale of 1-5. Direct mathematic measurement of the alpha angle was done by a third independent observer and correlated with the subjective results. Correlations between the subjective and measured angles and interobserver variation were calculated. RESULTS Statistically, significant variability was seen in the subjective assessment of the alpha angle. When the alpha angle was > 55 degrees, the area under the receiver operating characteristic curve (AUC) was 0.606, indicating that visual assessment is a poor predictor of a wide alpha angle. Even in patients with a measured normal alpha angle (< 55 degrees), slightly fewer than half were subjectively thought to possibly, likely, or definitely have abnormal angles. Similarly, more than half of the abnormal cases (alpha angles > 55 degrees) were subjectively thought to possibly or probably be normal. CONCLUSION Subjective assessment of alpha angles is suboptimal unless one is quite confident of a bone abnormality.
General and abdominal adiposity and risk of death in Europe.

BACKGROUND Previous studies have relied predominantly on the body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) to assess the association of adiposity with the risk of death, but few have examined whether the distribution of body fat contributes to the prediction of death. METHODS We examined the association of BMI, waist circumference, and waist-to-hip ratio with the risk of death among 359,387 participants from nine countries in the European Prospective Investigation into Cancer and Nutrition (EPIC). We used a Cox regression analysis, with age as the time variable, and stratified the models according to study center and age at recruitment, with further adjustment for educational level, smoking status, alcohol consumption, physical activity, and height. RESULTS During a mean follow-up of 9.7 years, 14,723 participants died. The lowest risks of death related to BMI were observed at a BMI of 25.3 for men and 24.3 for women. After adjustment for BMI, waist circumference and waist-to-hip ratio were strongly associated with the risk of death. Relative risks among men and women in the highest quintile of waist circumference were 2.05 (95% confidence interval [CI], 1.80 to 2.33) and 1.78 (95% CI, 1.56 to 2.04), respectively, and in the highest quintile of waist-to-hip ratio, the relative risks were 1.68 (95% CI, 1.53 to 1.84) and 1.51 (95% CI, 1.37 to 1.66), respectively. BMI remained significantly associated with the risk of death in models that included waist circumference or waist-to-hip ratio (P<0.001). CONCLUSIONS These data suggest that both general adiposity and abdominal adiposity are associated with the risk of death and support the use of waist circumference or waist-to-hip ratio in addition to BMI in assessing the risk of death.
Traditional and Contemporary Female Beauty Ideals in China: Focus Group Interviews with Young Chinese Women

The current study was aimed to examine how young Chinese women define the cultural standards of female ideal beauty in contemporary China as well as traditional concepts of female beauty using a qualitative research approach. A total of 23 female Chinese students (ages between 20 and 22) enrolled in Donghua University in Shanghai were recruited for focus-group interviews. The most frequently mentioned characteristics of the traditional female beauty ideal were (being) fat, followed by a round face. Characteristics of female beauty ideals in Contemporary China included a slim body, followed by a small face. Women in contemporary China seem to endorse much of the Western standards for female beauty ideals pervasive in media images. Traditional concepts of female beauty seem to have changed in the context of rapid and disruptive social change, particularly changing gender roles for women.
GUIDE: A Scalable Information Directory Service to Collect, Federate, and Analyze Logs for Operational Insights into a Leadership HPC Facility

In this paper, we describe the GUIDE framework used to collect, federate, and analyze log data from the Oak Ridge Leadership Computing Facility (OLCF), and how we use that data to derive insights into facility operations. We collect system logs and extract monitoring data at every level of the various OLCF subsystems, and have developed a suite of pre-processing tools to make the raw data consumable. The cleansed logs are then ingested and federated into a central, scalable data warehouse, Splunk, that offers storage, indexing, querying, and visualization capabilities. We have further developed and deployed a set of tools to analyze these multiple disparate log streams in concert and derive operational insights. We describe our experience from developing and deploying the GUIDE infrastructure, and deriving valuable insights on the various subsystems, based on two years of operations in the production OLCF environment. CCS CONCEPTS • General and reference → Performance; Measurement; Reliability; Metrics; • Information systems → Data warehouses; Extraction, transformation and loading; Data analytics; Data mining;
Intergovernmental councils in the United States

ABSTRACT This article focuses on intergovernmental councils (IGCs) in the United States in which prominent state-level executive politicians, that is, governors, play a leadership role. In the US case, these IGCs developed out of a desire to facilitate interstate information exchanges and a need for state governments to join forces to protect their autonomy vis-à-vis the federal government. In this latter role, the councils function as lobbyists for state government interests. The research question driving the analysis has to do with impact: what difference do executive-led IGCs make, either vertically or horizontally, in the US federal system? The question of impact is particularly relevant because growing partisan polarization in contemporary federal and state political institutions complicates collective action by states.
Evaluation and Improvement of Electromechanical Oscillation Damping By Means of Eigenvalue-Eigenvector Analysis. Practical Results in the Central Peru Power System

To eliminate oscillatory instability in electric power systems by inserting stabilizers, it is important to have available analytical criteria for the choice of the most suitable generators to which to put the stabilizing feedbacks, and for defining the most convenient parameters for them, without resorting to simulation. Applying some properties of control systems it is possible to set up digital programs based on calculations of eigenvalues and eigenvectors that solve these problems satisfactorily. The report then shows application of the procedures thus defined to a practical case of instability, and field test results that confinn the elimination of instability.
Energy-efficient Cooperative Sensing Schedule for heterogenous users in Cognitive Radio Networks

In this paper, we study the Cooperative Sensing Scheduling (CSS) problem for Cognitive Radio Network (CRN), from the perspective of balance between sensing performance and energy consumption. We place this problem in a practical scenario where both the primary users (PUs) and the secondary users (SUs) are heterogeneous: PU channels are different in terms of channel admission control, idle probability and channel capacity; SUs differs in sensing performance and sensing energy consumption. We formulate the CSS problem as a programming problem, whose optimal solution is proved to exist but takes considerable time and energy to reach. We then propose two heuristic algorithms, i.e., Centralized Algorithm and Multi-oligarch Algorithm, to obtain sub-optimal solutions. A Revised Initialization algorithm is also presented to improve the performance of these two algorithms. Simulation results show that the two algorithms achieve sub-optimal solutions with efficiency and effectiveness.
National-Level Family Policies and workers’ Access to Schedule Control in a European Comparative Perspective: Crowding Out or In, and for Whom?

Abstract This paper examines national-level family policies in a comparative perspective, to see whether they “crowd out” company-level family-friendly policies, namely schedule control. Further, it examines whether this relationship varies for different types of family policies, and for different groups of workers – i.e. distinguished by gender, parenthood status and skill divisions. The paper uses data from 27 European countries in 2010, and applies multilevel random slopes models with cross-level interaction terms. Results show that generous national-level family policies, in particular work-facilitating policies, “crowd in” company-level schedule control provisions, especially for high-skilled workers. However, very generous leave entitlements seem to crowd out schedule control provision.
Identification of humoral antigenic determinants in the hepatitis C virus NS3 protein.

Immunoblot analysis on serum samples from 90 patients with chronic hepatitis C virus infection revealed four putative immunogenic regions within the NS3 protein of the virus: E (around aa 1250/ 1251), A (within aa 1250-1334), A/B (around aa 1323 and 1334), and B/C (around aa 1407 and 1412). Among them, region E was most immunodominant, and region A was recognized much less frequently by patients with cirrhosis than by those with chronic hepatitis (10% vs. 46%, chi 2 = 12.05, P < .01). The results suggest that region A might be a potential prognostic marker to differentiate chronic hepatitis from cirrhosis.
Inferring Genome-Wide Gene Regulatory Networks with GPU or CPU Parallel Algorithm

Abstract Expression of gene block, with the GPU parallel thread structure characteristic calculation, according to the structural characteristics of GPU thread design of double parallel mode, and the use of texture cache memory to achieve high efficiency; on the basis of CPU two level cache capacity of basic blocks further subdivided into sub blocks to improve the cache hit rate, the technology to reduce the number of memory accesses the use of data, reduce the thread migration in the core between the use of thread binding technology; according to the calculated capacity allocation of multi-core CPU and GPU CPU and GPU gene in the mutual information calculation task to calculate the load balance of CPU and GPU; in the design of the new threshold calculation algorithm based on the design and implementation of memory efficient construction of global gene control network CPU /GPU parallel algorithm. The experimental results show that compared with the existing algorithms, this algorithm speed is more obvious, and is able to build more large-scale global gene regulation Control network.
PKCS #12: Personal Information Exchange Syntax v1.1

PKCS #12 v1.1 describes a transfer syntax for personal identity information, including private keys, certificates, miscellaneous secrets, and extensions. Machines, applications, browsers, Internet kiosks, and so on, that support this standard will allow a user to import, export, and exercise a single set of personal identity information. This standard supports direct transfer of personal information under several privacy and integrity modes. This document represents a republication of PKCS #12 v1.1 from RSA Laboratories' Public Key Cryptography Standard (PKCS) series. By publishing this RFC, change control is transferred to the IETF.
Enhancing consumer attitudes toward a website as a contributing factor in business success

This paper examines how consumers develop their attitude toward a destination website and are influenced by its usability, perceived risk and perceived usefulness – all of which can enhance their purchase intention. To create an authentic browsing scenario for the study, a website was specially designed for a fictitious tourist destination. Participants were invited to browse the site freely while carrying out the task assigned to them. This approach contributed added value to the research by simulating the real behavior of consumers who are faced with a range of options when selecting their purchase. The findings confirm that perceived usability and usefulness exert a positive influence on attitude toward the website, while the effect of the perceived risk is negative. The key implication is that if tourism business managers can better understand how attitude toward a website is developed this will enable them to market their products and services more effectively.
How Cash Flow News and Discount Rate News Impact the Unexpected Stock Returns of Energy Firms of Pakistan

This study has used the model of Volunteeno (2000). The objective of this study is to analyse the impact of the cash flow news and discount rate news on stock returns of energy firms of Pakistan from 2000 to 2015. We used the balanced panel data technique. Estimated the random effect model after employing the Hausman Test. The results of this research show that only discount rate news is significance and positively related with unexpected stock return returns of energy firms which describe that increase in variability in the discount rate news increase the variability in unexpected stock returns. As cash flow news is insignificance which conclude that there is no permanent effect occur in the unexpected stock return due to change in book value and earning. Moreover these firms are large; it’s also concluded that large firms are not affected by the cash flow news
Cdt1 Phosphorylation by Cyclin A-dependent Kinases Negatively Regulates Its Function without Affecting Geminin Binding*

The current concept regarding cell cycle regulation of DNA replication is that Cdt1, together with origin recognition complex and CDC6 proteins, constitutes the machinery that loads the minichromosome maintenance complex, a candidate replicative helicase, onto chromatin during the G1 phase. The actions of origin recognition complex and CDC6 are suppressed through phosphorylation by cyclin-dependent kinases (Cdks) after S phase to prohibit rereplication. It has been suggested in metazoan cells that the function of Cdt1 is blocked through binding to an inhibitor protein, geminin. However, the functional relationship between the Cdt1-geminin system and Cdks remains to be clarified. In this report, we demonstrate that human Cdt1 is phosphorylated by cyclin A-dependent kinases dependent on its cyclin-binding motif. Cdk phosphorylation resulted in the binding of Cdt1 to the F-box protein Skp2 and subsequent degradation. In contrast, in vitro DNA binding activity of Cdt1 was inhibited by the phosphorylation. However, geminin binding to Cdt1 was not affected by the phosphorylation. Finally we provide evidence that inactivation of Cdk1 results in Cdt1 dephosphorylation and rebinding to chromatin in murine FT210 cells synchronized around the G2/M phase. Taken together, these findings suggest that Cdt1 function is also negatively regulated by the Cdk phosphorylation independent of geminin binding.
Incorporation of Quantum Dots into 3D Photonic Crystals for Emission Control

This article demonstrates infiltration and doping as two efficient and flexible methods for incorporation of PbSe quantum dots (QDs) into three-dimensional (3D) photonic crystals. QDs induced photonic band gap shift was observed by the infiltration method. By employing the two-photon polymerisation technique, 3D photonic crystals were fabricated with QDs doped resin. Investigation will be focused on radiation dynamics and emission control of QDs in 3D photonic crystals
A model-based analysis of the clinical and economic impact of personalising P2Y12-receptor inhibition with platelet function testing in acute coronary syndrome patients

Summary Although some observational studies reported that the measured level of P2Y12-inhibition is predictive for thrombotic events, the clinical and economic benefit of incorporating PFT to personalize P2Y12-receptor directed antiplatelet treatment is unknown. Here, we assessed the clinical impact and cost-effectiveness of selecting P2Y12-inhibitors based on platelet function testing (PFT) in acute coronary syndrome (ACS) patients undergoing PCI. A decision model was developed to analyse the health economic effects of different strategies. PFT-guided treatment was compared with the three options of general clopidogrel, prasugrel or ticagrelor treatment. In the PFT arm, low responders to clopidogrel received prasugrel, while normal responders carried on with clopidogrel. The associated endpoints in the model were cardiovascular death, stent thrombosis and major bleeding. With a simulated cohort of 10,000 patients treated for one year, there were 93 less events in the PFT arm compared to general clopidogrel. In prasugrel and ticagrelor arms, 110 and 86 events were prevented compared to clopidogrel treatment, respectively. The total expected costs (including event costs, drug costs and PFT costs) for generic clopidogrel therapy were US$ 1,059/patient. In the PFT arm, total costs were US$ 1,494, while in the prasugrel and ticagrelor branches they were US$ 3,102 and US$ 3,771, respectively. The incrementalcost- effectiveness-ratio (ICER) was US$ 46,770 for PFT-guided therapy, US$ 185,783 for prasugrel and US$ 315,360 for ticagrelor. In this model-based analysis, a PFT-guided therapy may have fewer adverse outcomes than general treatment with clopidogrel and may be more cost-effective than prasugrel or ticagrelor treatment in ACS patients undergoing PCI.
Localization of a Proteolytic Enzyme Within the Efferent and Deferent Duct Epithelial Cells of the Turkey (Meleagris gallopavo) Using Immunohistochemistry1

Abstract Turkey seminal plasma contains a serine protease found to be distinct from the spermatozoal acrosin. However, the origin and biological roles of this enzyme are unknown. Our experimental objective was to identify the cellular source of this protease within the male reproductive tract. The enzyme was isolated from seminal plasma using benzamidine-Sepharose 6B chromatography. A synthetic substrate, Nα-benzoyl-dl-arginine p-nitroanilide, was used to detect fractions containing the enzyme. The affinity chromatography technique yielded a 150-fold increase in amidase activity. Analysis of the protease by SDS-PAGE revealed two protein bands with relative molecular masses of 37 000 and 61 000. Proteolytic activity was detected within the smaller band as evidenced by casein digestion. Further analysis of the purified protein revealed that the smaller protein band was glycosylated. To determine the cellular source of the protease, a panel of mouse monoclonal antibodies was then developed against the purified protease, and used in immunohistochemistry. Frozen tissue sections from the liver, testis, epididymal region, and deferent duct were fixed in 4% (w/v) paraformaldehyde, permeabilized with 0.2% (v/v) (octylphenoxy)polyethoxyethanol followed by routine immunohistochemistry procedures. Monoclonal antibodies did not bind to tissue sections from either the liver or testis, or to blood plasma proteins. Both the distal portion of the efferent duct and the deferent duct were immunoreactive. We concluded that the protease found in turkey seminal plasma is concentrated to the distal efferent duct and the deferent duct epithelial cells.