Miracle-dz/UniFAR-FTUs huggingface dataset:
In vivo quantification of capsular end-point in the nonimpaired glenohumeral joint using an instrumented measurement system.

STUDY DESIGN Single-group factorial. OBJECTIVES Quantify glenohumeral joint translations as a function of force using an instrumented measurement system. Our first specific aim was to compare the magnitude of force (N) required to reach capsular end-point between the anterior, posterior, and inferior directions. Our second specific aim was to compare the magnitude of translation (mm) at capsular end-point between the anterior, posterior, and inferior directions. BACKGROUND Manual force-displacement techniques are subjective in nature, and the clinician must rely on "feel" to determine capsular end-point. Several investigators have attempted to utilize more objective measures at the glenohumeral joint, however none have quantified the force or displacements necessary to achieve a true capsular end-point. METHODS AND MEASURES An arthrometric technique was used to measure anterior, posterior, and inferior glenohumeral translations in 20 nonimpaired shoulders (11 women and 9 men with a mean age of 20.9 +/- 3.6 years). RESULTS The magnitude of applied force required to reach capsular end-point was significantly different between directions of translations. Anterior-directed translations required a significantly greater magnitude of applied force to reach capsular end-point than inferior-directed translations. The magnitude of translation was not significantly different between directions at capsular end-point. CONCLUSIONS Applied forces in the range of 181 to 203 N are necessary to reach capsular end-point in subjects with nonimpaired shoulders. Anterior translation required significantly higher forces (203.1 +/- 13.1 N) to reach capsular end-point than inferior translation (181.4 +/- 31.9 N).
DOES THE PERCEIVED ENJOYMENT OF SOCIAL NETWORK SITES INFLUENCE THE DEVELOPMENT OF SOCIAL CAPITAL? A COMPARATIVE STUDY OF JAPAN AND BRAZIL

This study examines the relationship between the use of Social Network Sites and the formation of social capital. Using data from a web survey of employees in Japan (n = 244) and Brazil (n = 251), positive associations between SNS use and social capital development were found in both countries. Cultural differences seem to influence this process; in Brazil, intensity of SNS use has a stronger association with bridging and bonding social capital when perceived enjoyment is high; in Japan, employees use SNS for usefulness and enjoyment reasons, but perceived enjoyment does not interfere with social capital gains. Implications and future research are discussed.
Divergence at the casein haplotypes in dairy and meat goat breeds

Casein genes have been proved to have an influence on milk properties, and are in addition appropriate for phylogeny studies. A large number of casein polymorphisms exist in goats, making their analysis quite complex. The four casein loci were analyzed by molecular techniques for genetic polymorphism detection in the two dairy goat breeds Bunte Deutsche Edelziege (BDE; n=96), Weiße Deutsche Edelziege (WDE; n=91), and the meat goat breed Buren (n=75). Of the 35 analyzed alleles, 18 were found in BDE, and 17 in Buren goats and WDE. In addition, a new allele was identified at the CSN1S1 locus in the BDE, showing a frequency of 0·05. This variant, named CSN1S1*A′, is characterized by a t→c transversion in intron 9. Linkage disequilibrium was found at the casein haplotype in all three breeds. A total of 30 haplotypes showed frequencies higher than 0·01. In the Buren breed only one haplotype showed a frequency higher than 0·1. The ancestral haplotype B-A-A-B (in the order: CSN1S1-CSN2-CSN1S2-CSN3) occurred in all three breeds, showing a very high frequency (>0·8) in the Buren.
Drug-free mannosylated liposomes inhibit tumor growth by promoting the polarization of tumor-associated macrophages

Background: Tumor-associated macrophages (TAMs) are critical in tumor progression and metastasis. Selective targeting of TAMs holds great potential to ameliorate the immunosuppressive tumor microenvironment and enhance the efficacy of antitumor therapy. Various liposomes have been developed to target TAMs via cell-specific surface receptors either to deplete or re-educate TAMs. Since immuno-stimulation often initiates with the interaction of nanocarriers with the innate immunity cells such as macrophages, the intrinsic impact of drug-free liposomes on macrophage activation and polarization via cell interaction is one of the most critical issues in nanomedicine for promoting effective immunotherapy. Methods: In this study, conventional bare liposomes, PEGylated liposomes, and mannosylated liposomes were developed and the cytotoxicity, cellular internalization, immunostimulatory activity, targeting efficiency, antitumor efficacy, and mechanism were evaluated in vitro and in vivo. Results: All liposomes displayed an ideal particle size, good biocompatibility, and controlled release behavior. Mannosylated liposomes exhibited superior in vitro cellular internalization and tumor spheroid penetration with the aid of the mannose receptor-mediated TAMs-targeting effects. In particular, mannosylated liposomes promoted the polarization of both M0 and M2 to the M1 phenotype by enhancing the expression ratio of CD86/CD206 in vitro. Of note, mannosylated liposomes could inhibit G422 glioma tumor growth, which may be attributed to the polarization of TAMs, as evidenced by the reduction in expression level of the TAMs surface marker. Conclusion: These results indicate the potential value of mannosylated liposomes in the design of a rational delivery system to enhance the antitumor immune efficacy of immunomodulators by inducing a shift from the M2 to the M1 phenotype.
Hunting‐mediated predator facilitation and superadditive mortality in a European ungulate

Abstract Predator‐prey theory predicts that in the presence of multiple types of predators using a common prey, predator facilitation may result as a consequence of contrasting prey defense mechanisms, where reducing the risk from one predator increases the risk from the other. While predator facilitation is well established in natural predator‐prey systems, little attention has been paid to situations where human hunters compete with natural predators for the same prey. Here, we investigate hunting‐mediated predator facilitation in a hunter‐predator‐prey system. We found that hunter avoidance by roe deer (Capreolus capreolus) exposed them to increase predation risk by Eurasian lynx (Lynx lynx). Lynx responded by increasing their activity and predation on deer, providing evidence that superadditive hunting mortality may be occurring through predator facilitation. Our results reveal a new pathway through which human hunters, in their role as top predators, may affect species interactions at lower trophic levels and thus drive ecosystem processes.
Humoral Immune Response to Influenza A ( H 1 N 1 ) pdm 2009 in Patients with Natural Infection and in Vaccine Recipients in the 2009 Pandemic

The 2009 pandemic H1N1 mainly affected adolescents and children, and most of the elderly in Japan escaped clinical illness. To clarify the role of humoral immunity in the infection, the time kinetics of hemagglutination inhibition (HI), neutralization (NT), and IgG subclass antibody response directed against influenza A(H1N1)pdm2009 were analyzed in three consecutive specimens obtained from 51 young adults and children (group 1) who contracted pandemic influenza and from 74 pediatric clinic employees (group 2) inoculated with pandemic monovalent vaccine. In group 1 patients, 6 and 30 patients had lower HI and NT antibody in the acute phase respectively. Thereafter, HI and NT antibody titers increased fourfold or more in 50 patients with peak response in the third specimens obtained four weeks after the onset. IgG1 in 45 patients, IgG3 in 18 patients, and IgG4 in 29 patients showed elevated responses. Forty (54%) and 70 (95%) subjects in group 2 had positive HI and NT antibodies in the prevaccination samples, with increased antibody responses in the follow-up peaking in the second specimens. Forty of those vaccinated had increased IgG1 responses peaking in the third specimens, whereas elevated IgG3 was observed in 22 recipients with the highest level in the second samples. IgG4 did not show any increase in subjects in group 2. A few participants showed an IgG2 response in both groups. An immunologically naive population contracted influenza with apparent clinical symptoms. However, already primed subjects through subclinical infection elicited the unique pattern of IgG subclass responses by vaccination, which differed from those of naive populations.
Cross-Language Plagiarism Detection System Using Latent Semantic Analysis and Learning Vector Quantization

Computerized cross-language plagiarism detection has recently become essential. With the scarcity of scientific publications in Bahasa Indonesia, many Indonesian authors frequently consult publications in English in order to boost the quantity of scientific publications in Bahasa Indonesia (which is currently rising). Due to the syntax disparity between Bahasa Indonesia and English, most of the existing methods for automated cross-language plagiarism detection do not provide satisfactory results. This paper analyses the probability of developing Latent Semantic Analysis (LSA) for a computerized cross-language plagiarism detector for two languages with different syntax. To improve performance, various alterations in LSA are suggested. By using a linear vector quantization (LVQ) classifier in the LSA and taking into account the Frobenius norm, output has reached up to 65.98% in accuracy. The results of the experiments showed that the best accuracy achieved is 87% with a document size of 6 words, and the document definition size must be kept below 10 words in order to maintain high accuracy. Additionally, based on experimental results, this paper suggests utilizing the frequency occurrence method as opposed to the binary method for the term–document matrix construction.
Population receptive field and connectivity properties of the early visual cortex in human albinism

In albinism, the pathological decussation of the temporal retinal afferents at the optic chiasm leads to superimposed representations of opposing hemifields in the visual cortex. Here, we assessed the equivalence of the two representations and the cortico-cortical connectivity of the early visual areas. Applying fMRI-based population receptive field (pRF)-mapping (both hemifield and bilateral mapping) and connective field (CF)-modeling, we investigated the early visual cortex in 6 albinotic participants and 4 controls. In albinism, superimposed retinotopic representations of the contra- and ipsilateral visual hemifield were observed on the hemisphere contralateral to the stimulated eye. This was confirmed by the observation of bilateral pRFs during bilateral mapping. Hemifield mapping revealed similar pRF-sizes for both hemifield representations throughout V1 to V3. The typical increase of V1-sampling extent for V3 compared to V2 was not found for the albinotic participants. The similarity of the pRF-sizes for opposing visual hemifield representations highlights the equivalence of the two maps in the early visual cortex. The altered V1-sampling extent in V3 indicates the adaptation of cortico-cortical connections to the abnormal input of the visual cortex. These findings thus suggest that conservative developmental mechanisms are complemented by alterations of the extrastriate cortico-cortical connectivity. Highlights pRF mapping confirms cortical overlay of opposing visual hemifields in albinism. Equivalent information processing of both hemifields is indicated by similar pRF sizes. CF modeling indicates changes to the cortico-cortical connections at the level of V3.
Velocity aided attitude estimation on SO(3) with sensor delay

This paper provides a nonlinear attitude estimation method for vehicles performing high acceleration maneuvers when measurements of linear velocity and the ambient magnetic field are delayed. Linear velocity is measured using the Global Positioning System (GPS) and the delays of GPS and magnetometer measurements are assumed to be known constants. Our proposed method consists of a delayed observer coupled with a dynamic predictor. The delayed observer uses delayed measurements and provides estimates of delayed attitude and velocity states that are in turn used in the predictor to generate estimates of the current attitude and velocity. A key contribution of the paper is effective use of the underlying symmetries of the system in order to design a generic predictor that can be coupled to different observers. We prove exponential convergence of the predicted attitude and velocity for a specific observer choice drawn from the literature.
Adaptive indoor positioning algorithm using auto-calibration

This paper describes an adaptive algorithm to calculate the position of wireless mobile devices in a heterogeneous environment such as a building, house or flat. Because the environment is not static, it is very important to measure the signal strength of wireless communications periodically in order to take into account all the modifications in the indoor area. These continuous measurements are taken between Wi-Fi Access-points. Such an algorithm allows to keep a good level of accuracy avoiding a degradation of the calculated position over the time. Our adaptive algorithm has been integrated into fault tolerant, redundant and scalable architecture.
On the U.S. Budget Deficit Dilemma: Has Television Contributed?

We advance several theoretical reasons for arguing that expansion in television viewership may have contributed to the recent escalation in the U.S. budget deficit. We then develop a multivariate model to test the validity of the hypothesis using alternative measures of television viewership. The empirical results could not reject our contention that the fast evolution of the U.S. television viewership since the early 1970s has significantly contributed to the escalating size of the federal budget deficit over and above the effects of several other possible macro determinants. This evidence provides some support to the claim that there exists a “liberal” bias within the media (particularly television) that undermines fiscal conservatism. Therefore, it appears advisable for policy-makers to take into account the role of television if they aspire to understand and ultimately control the mounting federal budget deficit.
Statin-Induced Cholesterol Lowering and Plaque Regression After 6 Months of Magnetic Resonance Imaging–Monitored Therapy

Background—Statin therapy reduces adverse outcomes, with a minimal decrease in vessel stenosis. Magnetic resonance imaging (MRI) noninvasively detects atherosclerotic plaque (AP) reduction. We hypothesized that statin-induced AP regression can be monitored by MRI and detected earlier than previously reported and is significantly associated with its lipid-lowering effect. Methods and Results—APs in thoracic aorta were measured by combined surface/transesophageal MRI in 27 patients (treated with simvastatin 20 to 80 mg daily) before and after 6 months of therapy. AP volume and luminal dimensions were measured from 6 cross sections used to construct a 2.4-cm 3D volume of the aorta that included plaque and lumen. Method reproducibility was studied in 10 patients imaged twice, 1 week apart. AP volume was reduced from 3.3±0.1.4 to 2.9±1.4 cm3 at 6 months (P<0.02), whereas luminal volume increase was less accentuated (from 12.0±3.9 to 12.2±3.7 cm3, P<0.06). LDL cholesterol decreased by 23% (from 125±32 to 97±27 mg/dL, P<0.05) in 6 months. AP regression (plaque volume/area reduction) was significantly related to LDL cholesterol reduction (P<0.02 and P<0.005, respectively), and luminal volume increase was inversely related to LDL cholesterol reduction (P<0.04). Plaque volume measurement was highly reproducible (intraclass correlation R=0.98 and variability=4.8%). Intraobserver (0.91) and interobserver (0.81) concordances were documented for plaque volume assessment. Conclusions—AP regression and reverse remodeling can be detected accurately by MRI 6 months after statin therapy initiation, and it is strongly associated with LDL cholesterol reduction.
A Novel Interaction of tRNALys,3 with the Feline Immunodeficiency Virus RNA Genome Governs Initiation of Minus Strand DNA Synthesis*

Complementarity between nucleotides at the 5′ terminus of tRNALys,3 and the U5-IR loop of the feline immunodeficiency virus RNA genome suggests a novel intermolecular interaction controls initiation of minus strand synthesis in a manner analogous to other retroviral systems. Base pairing of this tRNA-viral RNA duplex was confirmed by nuclease mapping of the RNA genome containing full-length or 5′-deleted variants of tRNALys,3 hybridized to the primer-binding site. A major pause in RNA-dependent DNA synthesis occurred 14 nucleotides ahead of the primer-binding site with natural and synthetic tRNALys,3 primers, indicating it was not a consequence of tRNA base modifications. The majority of the paused complexes resulted in dissociation of the reverse transcriptase from the template/primer, as demonstrated by an assay limited to a single binding event. Hybridization of a tRNA mutant whose 5′ nucleotides are deleted relieved pausing at this position and subsequently allowed high level DNA synthesis. Additional experiments with tRNA-DNA chimeric primers were used to localize the stage of minus strand synthesis at which the tRNA-viral RNA interaction was disrupted. Finally, replacing nucleotides of the feline immunodeficiency virus U5-IR loop with the (A)4 sequence of its human immunodeficiency virus (HIV)-1 counterpart also relieved pausing, but did not induce pausing immediately downstream of the primer-binding site previously noted during initiation of HIV-1 DNA synthesis. These combined observations provide further evidence of cis-acting sequences immediately adjacent to the primer-binding site controlling initiation of minus strand DNA synthesis in retroviruses and retrotransposons.
Pareto Improving Climate Policies: Distributing the Benefits Across Generations and Regions

Most studies show that the present generation has to take the burden and reduce consumption to mitigate future climate change. However, significant climate change is due to a market failure, and corrections of market failures give possibilities of Pareto improvements. In this paper, we study the implication of Pareto improving climate policies. We use the representative consumer model RICE-10, which is a global model with different regions, to see how the benefits can be distributed across and within generations. The model shows that while the social optimum by definition is on the Pareto efficiency frontier, it is not necessary on the Pareto improving frontier, and that different combinations of present and future consumption along the Pareto improving frontier would give different combinations of capital investments and emissions. We find that all Pareto improving policies have higher total emissions than the social optimum when transfers are allowed. Without the possibility of transfers, total emissions may be lower than under the social optimum. Moreover, in this case carbon taxes differ substantially between regions for all Pareto improving policies.
Flavonoid Biosynthesis Pathway Participating in Salt Resistance in a Landrace Sweet Sorghum Revealed by RNA-Sequencing Comparison With Grain Sorghum

Abiotic stresses affect crop productivity worldwide. Plants have developed defense mechanisms against environmental stresses by altering the gene expression pattern which leads to regulation of certain metabolic and defensive pathways. Sorghum [Sorghum bicolor (L.) Moench] is an important crop in those regions irrigated by salty water. Sweet sorghum is a variant of common grain sorghum and is relatively more adapted to marginal growing conditions. Here, we compared the different response to salt stress of sweet and grain sorghum. We investigated six traits related with seed germination under salt-stress and normal conditions, conducted a genome-wide research on the salt effect on the gene expression of a landrace sweet and two grain sorghum by RNA-sequencing at seedling stage. The results showed that salt stress had significant inhibition to sorghum seed germination capability, and the inhibition to grain sorghum was greater. By comparing sweet and grain sorghum and the KEGG pathway analysis based on the DEGs, six genes involved in flavonoid biosynthesis pathway to tannins and anthocyanins from phenylalanine were identified in the landrace sweet sorghum, which expression was significant different with that in grain sorghum. Quantitative real-time PCR (qRT-PCR) data were closely in accordance with the transcript patterns estimated from the RNA-seq data. Tannins accumulation changes were associated with the genes expression under salt stress and control. These suggested that flavonoid biosynthesis pathway was involved in the sorghum resistance to salt stress. The present results suggested that flavonoid biosynthesis plays an important role in the sweet sorghum capacity for salt tolerance.
Podoplanin expression by cancer‐associated fibroblasts predicts poor outcome in invasive ductal breast carcinoma

Pula B, Jethon A, Piotrowska A, Gomulkiewicz A, Owczarek T, Calik J, Wojnar A, Witkiewicz W, Rys J, Ugorski M, Dziegiel P & Podhorska‐Okolow M (2011) Histopathology 59, 1249–1260 Podoplanin expression by cancer‐associated fibroblasts predicts poor outcome in invasive ductal breast carcinoma
Induction of a Futile Embden-Meyerhof-Parnas Pathway in Deinococcus radiodurans by Mn: Possible Role of the Pentose Phosphate Pathway in Cell Survival

ABSTRACT Statistical models were used to predict the effects of tryptone, glucose, yeast extract (TGY) and Mn on biomass formation of the highly radioresistant bacterium Deinococcus radiodurans. Results suggested that glucose had marginal effect on biomass buildup, but Mn was a significant factor for biomass formation. Mn also facilitated glucose interactions with other nutrient components. These predictions were verified by in vivo and in vitro experiments. TGY-grown cells metabolized glucose solely by the pentose phosphate pathway (PPP). Although only a fraction of glucose from the medium was transported into the cells, glucose was incorporated into the DNA efficiently after cells were exposed to UV light. The presence of glucose also enhanced the radioresistance of the culture. Mn could induce an Embden-Meyerhof-Parnas (EMP) pathway in D. radiodurans. The EMP pathway and the PPP of the Mn-treated cells oxidized glucose simultaneously at a 6:1 ratio. Although glucose was hydrolyzed rapidly by the Mn-treated cells, most glucose was released as CO2. Mn-treated cultures retained less glucose per cell than cells grown without Mn, and still less glucose was incorporated into the DNA after cells were exposed to UV light. Mn-treated cells were also more sensitive to UV light. Results suggested that metabolites of glucose generated from the PPP enhanced the survival of D. radiodurans. Induction of the EMP pathway by Mn may deplete metabolites for DNA repair and may induce oxidative stress for the cell, leading to reduction of radioresistance.
Accuracy of international ultrasound risk stratification systems in thyroid lesions cytologically classified as indeterminate

Eminent international societies have published their thyroid ultrasound risk stratification system (US‐RSS) to give a friendly tool for thyroidologists. In particular, American Thyroid Association (ATA), American Association Clinical Endocrinologists/American College of Endocrinologists and Associazione Medici Endocrinologi (AACE/ACE/AME), British Thyroid Association (BTA), and Thyroid Imaging Reporting and Data System (TIRADS) are often adopted for clinical practice. The reliability of these US‐RSS has not been evaluated in discriminating cancers from benignancy in nodules with indeterminate FNA.