Miracle-dz/UniFAR-FTUs huggingface dataset:
Wernicke's Encephalopathy Complicating Pregnancy in a Woman with Neonatal Necrotizing Enterocolitis and Resultant Chronic Malabsorption

Wernicke's encephalopathy (WE) is a metabolic disturbance resulting from severe thiamine deficiency classically described in malnourished alcoholics. Untreated, it can result in stupor, coma, and death. WE has previously been reported as a complication of pregnancy in women with hyperemesis gravidarum. We report a case of WE complicating pregnancy in a woman with chronic malabsorption secondary to premature birth and subsequent necrotizing enterocolitis (NEC). Our patient progressed through classic stages of WE before lapsing into a coma. She made a complete recovery after aggressive intravenous thiamine and nutritional support. This is the first report of WE in pregnancy secondary to NEC-related chronic malabsorption. We report this case to bring attention to a potential pregnancy complication affecting women with malabsorptive conditions.
Regulation of Gonadotropin-Releasing Hormone (GnRH) Receptor-I Expression in the Pituitary and Ovary by a GnRH Agonist and Antagonist

The aim of the current study was to examine the effects of gonadotropin-releasing hormone agonist (GnRH-a) and antagonist (GnRH-ant) on the expression of GnRH receptor-I (GnRHR-I) in pituitary and ovaries in cyclophosphamide (CTX) chemotherapeutic rats and to investigate the possible mechanism of interventions of GnRH-a and GnRH-ant in CTX-induced ovarian damage. In total, 36 female rats were distributed into 6 groups at random: normal saline (NS) group, CTX group, GnRH-a + NS group, GnRH-a + CTX group, GnRH-ant + NS group, and GnRH-ant + CTX group. After the rats were killed, the expression of GnRHR-I messenger RNAs (mRNAs) and proteins in pituitary and ovaries were examined by reverse transcriptase polymerase chain reaction (RT-PCR) and Western blot, respectively. The distribution of GnRHR-I in various compartments of the ovaries was observed by immunohistochemistry. Significant downregulation of GnRHR-I mRNA and protein expression in the pituitary were observed after treatment with GnRH-a or GnRH-ant. Moreover, GnRH-ant was more potent for this direct and fast inhibition. In ovary, GnRHR-I expression was significantly downregulated by GnRH-a. Although GnRH-ant slightly decreased the ovarian expression of GnRHR-I mRNA, the protein level was only weakly changed. In the ovarian compartment, GnRHR-ant groups had markedly GnRHR-I expression in early and late growing follicles compared to GnRHR-a groups that exhibited decreased expression of GnRHR-I, especially in late growing follicles. In summary, this study presents evidence for the different regulating effects of GnRH-a and GnRH-ant on the expression of GnRHR-I in pituitary and ovaries, which may provide insight into the mechanism of GnRH-a and GnRH-ant interventions on chemotoxic ovarian damage.
Vnodes: An Architecture for Multiple File System Types in Sun UNIX

All file system operations should be atomic. In other words, the set of interface operations should be at a high enough level so that there is no need for locking (hard locking, not user advisory locking) across several operations. Locking, if required, should be left up to the file system implementation dependent layer. For example, if a relatively slow computer running a remote file system requires a supercomputer server to lock a file while it does several operations, the users of the supercomputer would be noticeably affected. It is much better to give the file system dependent code full information about what operation is being done and let it decide what locking is necessary and practical.
ORNL Experience and Challenges Facing Dynamic Wireless Power Charging of EV's

As visionary as dynamic, or in-motion, wireless charging of electric vehicles appears the concept is well over a century old as this paper will show. This is because the concept of magnetic induction dates back to the pioneering work of physicist Michael Faraday in the early 19th century. Today wireless power transfer (WPT) is being standardized for stationary and quasi-stationary charging of electric vehicles (EV). The Society of Automotive Engineers (SAE) has undertaken the standardization of stationary charging and will make this public during 2016. In addition to this the IEEE-SA (Standards Activities) initiated standards development for EV? s in their EVWPT working group in 2012. This paper introduces the many challenges facing EVWPT in not only high power transfer to a moving vehicle and energy management at a utility scale, but communications in a vehicle to infrastructure (V2I) environment and management of high data rates, ultra-low latency, and dealing with communications loss in dense urban areas. Future concepts such as guideway powering of EV? s are presented to illustrate one technical trajectory EVWPT may take.
Aspirin Intake Correlates With Halted Growth of Sporadic Vestibular Schwannoma In Vivo

Objective Given the presence of a pathological immune response in sporadic vestibular schwannoma (sVS), this study aims to explore the roles of aspirin in minimizing sVS growth in vivo. Study Design Retrospective case review. Setting Tertiary care hospital. Patients People diagnosed with sVS and followed at a tertiary referral center by serial magnetic resonance imaging (MRI) for at least 4 months within the period of January 1980 through April 2012. Main Outcome Measures Patient use of aspirin and sVS growth rate measured by changes in the largest tumor dimension as noted on serial MRIs Results Within a set of 689 cases, 347 were followed by serial MRI scans (50.3%); of the latter, 81 took aspirin, of which, 33 demonstrated sVS growth, and 48 did not. Of the 266 nonaspirin users, 154 demonstrated sVS growth, and 112 did not. A significant inverse association was found among aspirin users and sVS growth (odds ratio [OR]: 0.50, 95% confidence interval [CI]: 0.29–0.85), which was not confounded by age or sex. Conclusion Our results suggest a potential therapeutic role of aspirin in inhibiting sVS growth.
Bilobed sialolipoma of parotid gland a rare entity

Lipoma is the most common benign tumour which occurs anywhere in the body where adipose tissue is present which is asymptomatic, slow growing and painless. The lipoma consists of mature adipose tissue and occurs commonly in region of back, shoulder and nape of neck. Adipose tissue also exists in the parotid gland, but lipoma of the parotid gland is rare entity. The incidence of this entity has been reported to be about 1% ranging from 0.6% to 4.4% [1]. The exact aetiology of parotid lipoma is not known. The occurrence of parotid lipoma has been most commonly correlated to the trauma in this region but exact pathophysiological mechanism is not described [2]. Lipoma is benign tumour arising from mesenchymal tissue mainly adipose tissue. Other mesenchymal tissue can combine with it to form angiolipoma, leiomylipoma, angiomyolipoma, fibrolipoma, neurolipoma, osteolipoma and chondrolipoma [3]. Ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI) and fine needle aspiration cytology (FNA) are of definite help in making preoperative diagnosis of parotid lipoma [4]. Once a definite diagnosis of parotid lipoma is available, this can be kept under wait and watch until the patient demands its surgical removal because of cosmetic reason. The operation can be planned avoiding the injury to facial nerve and its branches [5]. We report a case of sialolipoma in the left parotid of a 52 year old female woman because of relative rarity who was treated with limited excision.
AGRICULTURAL DEVELOPMENT IN ODISHA: ARE THE DISPARITIES GROWING?

In the recent years India’s agricultural sector has experienced significant changes in institutional and policy interventions and productivity at the national and sub-national levels. But although overall production has increased growth has slowed down, inter-state and intra-state disparities continue to remain very high and even widened in some cases. Using Principal Component Analysis technique and constructing district-wise agricultural development indices, this paper analyses the spatio-temporal variations in agricultural development in Odisha , India for 3 years over the period 2001-02 to 2011-12, identifies the underlying factors, examines inter-relationships and draws policy implications for improving the agricultural situation. Increasing public investment in agricultural infrastructure including irrigation, establishing appropriate farming systems , developing suitable and affordable technology and crop varieties, augmenting credit delivery and designing region and crop-specific plans and strategies are suggested for moderating spatial inequalities and achieving a less unbalanced regional development in agriculture.
A time-frequency approach for EEG signal segmentation

The record of human brain neural activities, namely electroencephalogram (EEG), is known to be nonstationary in general. In addition, the human head is a non-linear medium for such signals. In many applications, it is useful to divide the EEGs into segments in which the signals can be considered stationary. Here, Hilbert-Huang Transform (HHT), as an effective tool in signal processing is applied since unlike the traditional time-frequency approaches, it exploits the non-linearity of the medium and nonstationarity of the EEG signals. In addition, we use Singular Spectrum Analysis (SSA) in the pre-processing step as an effective noise removal approach. By using synthetic and real EEG signals, the proposed method is compared with Wavelet Generalized Likelihood Ratio (WGLR) algorithm as a well-known signal segmentation method. The simulation results indicate the performance superiority of the proposed method.
Hemodynamic and Cardiac Effects of Erythropoietin in Patients on Regular Dialysis

The long-term impact of erythropoietin (EPO) treatment on cardiac structures and function was prospectively studied in eight hypertensive (Group I) and seven normotensive (Group II) patients on hemodialysis (HD). Doppler-echocardiograms were done before EPO and at two and twelve months of treatment. Mean hemoglobin (± SD) before EPO was 6.4 ± 0.9; it rose significantly up to two months and then remained constant. At two months, cardiac index (CI) had significantly decreased, while peripheral vascular resistances increased. Five patients required increased antihypertensive drug treatment. No changes were seen in myocardial parameters at this short follow-up. After one year, left ventricular mass index (LVMi) decreased (p < 0.05) in both groups concomitantly with a decrease in diastolic diameter and septum and posterior wall thicknesses. Basal LVMi was higher in Group I than in Group II, and after one year the regression was more marked in Group II. Left cardiac work showed prompt and steady improvement in both groups. Maintained partial correction of anemia with EPO during one year was associated with a return to normal of high CI, decreased left cardiac work and impressive regression of left ventricular hypertrophy.
A Unified Tractography Framework for Comparing Diffusion Models on Clinical Scans

In this paper, we compare several parametric and non-parametric models of diffusion in a unified framework that allows simultaneous model estimation and tractography. The framework uses the Unscented Kalman Filter (UKF) to compare several variants of spherical harmonics (SH), i.e., SH with sharpening, spherical deconvolution, SH with solid angle and also several parametric models like single and two-tensor models with and without an additional “free water” component. We estimate all these models and perform tractography using the same optimizer, namely, the UKF. Comparison is done by tracing two fiber bundles whose connectivity is known from the literature on human anatomy. We trace these fiber bundles on 10 healthy subjects and compare how well each of these models perform on clinical in-vivo scans. For quantitative comparison, we propose two new measures; traceability and coverage, both of which capture how well each method performs in terms of tracing known fiber bundles. Our results show that, the two-tensor with “free-water” model performs very well for both these measures.
Validated Eco-Friendly Chromatographic Methods for Simultaneous Determination of Sacubitril and Valsartan in Spiked Human Plasma and in Pharmaceutical Formulation

© 2018 Amal Mahmoud Abou Al Alamein. This is an open access article distributed under the terms of the Creative Commons Attribution License -NonCommercialShareAlikeUnported License (http://creativecommons.org/licenses/by-nc-sa/3.0/). *Corresponding Author Amal Mahmoud Abou Al Alamein, Analytical Chemistry Department, Faculty of Pharmacy, Cairo University. E-mail: amal_alamein @ yahoo. com, amal.alamein @ pharma.cu. ecu.edu. eg Validated Eco-Friendly Chromatographic Methods for Simultaneous Determination of Sacubitril and Valsartan in Spiked Human Plasma and in Pharmaceutical Formulation
A Hybrid Greedy Randomized Adaptive Search Heuristic to Solve the Dial-a-Ride Problem

This paper presents a hybrid metaheuristic for solving the static dial-a-ride problem with heterogeneous vehicles and fixed costs. The hybridization combines a reactive greedy randomized adaptive search, used as outer scheme, with a tabu search heuristic in the local search phase. The algorithm is evaluated on well-known instances taken from the literature and on a set of randomly generated test problems, varying in the number of customers. Extensive computational results show the effectiveness of the hybrid approach in terms of trade-off between solution quality and computational time.
High-quality Ge films on Si substrates using Sb surfactant-mediated graded SiGe buffers

High-quality Ge films were grown on Si substrates by solid-source molecular beam epitaxy using SiGe graded layer and Sb surfactant-mediation technique. Transmission electron microscopy measurements show that samples grown using this method have a lower threading dislocation density than those grown by other typical methods, such as grading at high temperature (700 °C) only, grading at intermediate temperature (510 °C) only, and the use of low temperature Si buffer. A relaxed Ge film on a 4-μm-thick graded buffer was grown and shown to have a threading dislocation density of 5.4×105 cm−2 and surface roughness of 35 A. Ge p–i–n diodes were fabricated and tested. Under a reverse bias of 1 V, the p–i–n Ge mesa photodiodes exhibit a very low dark current density of 0.15 mA/cm2.
Dietary studies of athletes: an interview with sports dietitian Bronwen Lundy. Interview by Louise M. Burke.

The articles in this issue of IJSNEM include a dietary survey conducted by Bronwen Lundy and colleagues of professional Australian Rugby League players. As well as providing information on the nutritional practices of these team sport players, this study includes some insight into the techniques of collecting and interpreting dietary information from elite athletes. In this interview, we provide Bronwen with an opportunity to expand on this theme.
STRESS TESTING FOR LIQUIDITY RISK MANAGEMENT CASE OF CDG CAPITAL IN MOROCCO.

In response to the financial crisis and its repercussions on financial institutions, the new regulatory requirements relating to the management of bank liquidity have been introduced. For a better management of the liquidity risk, and a more adequate estimate of the potential risk incurred by the bank CDG Morocco, the stress tests represent a method for a precise evaluation of the risk. Liquidity risk is an important risk class, it needs its own risk measures such as the net stable financing rate (NSFR) and Liquidity Coverage Ratio (LCR) as prescribed by the Basel Committee on Banking Supervision (BCBS). The purpose of this paper is to study the liquidity of the CDG bank by the stress test technique to make decisions on the financial state of the bank.
Rhein ameliorates fatty liver disease through negative energy balance , hepatic lipogenic regulation , and immunomodulation in dietinduced dietinduced dietinduced obese mice

Sheng X, Wang M, Lu M, Xi B, Sheng H, Zang YQ. Rhein ameliorates fatty liver disease through negative energy balance, hepatic lipogenic regulation, and immunomodulation in diet-induced obese mice. Am J Physiol Endocrinol Metab 300: E886–E893, 2011. First published March 1, 2011; doi:10.1152/ajpendo.00332. 2010. — Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and inflammatory disorders. In this study, we tested the effect of rhein, a lipophilic anthraquinone derived from a traditional Chinese herbal medicine Rheum palmatum L. , on NAFLDassociated hepatic steatosis, insulin resistance, and the T helper (Th)1/Th2 cytokine imbalance in high-fat diet-induced obese (DIO) mice. We found that oral administration of rhein for 40 days significantly increased energy expenditure, reduced body weight, particularly body fat content, improved insulin resistance, and lowered circulating cholesterol levels in DIO mice without affecting food intake. Rhein treatment also reduced liver triglyceride levels, reversed hepatic steatosis, and normalized alanine aminotransferase (ALT) levels in these mice. Gene analysis and Western blot showed that rhein markedly suppressed the expression of the lipogenic enzyme sterol regulatory element-binding protein-1c (SREBP-1c) and its target genes in the liver. Luciferase reporter assay revealed that rhein suppressed the transcriptional activity of SREBP-1c through its upstream regulator, liver X receptor (LXR). This suggests that rhein exerts its effects by targeting LXR, which is also supported by its inability to reduce body weight in LXR knockout mice. Moreover, multiplex ELISA displayed a downregulated Th1 response after rhein treatment. Rhein shifted the Th1/Th2 responses by inhibiting T-box expressed in T-cells (T-bet) expression and enhancing GATA-binding protein-3 (GATA-3) expression through increased signal transducer and activator of transcription 6 (STAT6) phosphorylation. These data indicate that rhein ameliorated NAFLD and associated disorders through LXR-mediated negative energy balance, metabolic regulatory pathways, and immunomodulatory activities involved in hepatic steatosis. The combined effects of rhein to target hepatic metabolic and immune pathways may be beneficial for complex metabolic diseases such as NAFLD.
Use of melatonin as an adjuvant therapy in neonatal sepsis.

OBJECTIVE The objective of this study is to evaluate the therapeutic efficacy of melatonin as an adjuvant therapy in treating neonatal sepsis. PATIENTS AND METHODS A prospective clinical trial study was conducted on 50 infants with neonatal sepsis diagnosed on the basis of both clinical and laboratory criteria. Enrolled infants were divided into two groups. Intervention group (n = 25) received melatonin and antibiotics, while the control group (n = 25) was treated with antibiotics only. Melatonin was administered as a single oral dose of 20 mg and antibiotics were administered according to a standard protocol. Both groups were compared using a predefined sepsis score utilizing both clinical and laboratory parameters. RESULTS There was no significant difference in sepsis score between both groups before starting melatonin (p-value = 0.99), while there was significant difference in sepsis score between groups after 24 hours, 48 hours and 72 hours of starting melatonin with (p-value = 0.008, 0.006 and 0.002, respectively). There was significant improvement sepsis score in both groups with more improvement of sepsis score in the intervention group. CONCLUSION Administration of melatonin as an adjuvant therapy in the treatment of neonatal sepsis is associated with improvement of clinical and laboratory outcomes.
IT enablement in sugar supply chain: an approach for farmers

The study is to identify various issues at farmers' level on the basis of literature review and expert panel discussions for developing suitable relationship between them so that the facilitation of e-applications for optimising cane yield at farmer level can be made possible. A field survey was conducted for checking the relevance level of the identified issues at five-point Likert scale. A total of 30 sugar mills in Uttar Pradesh and Uttarakhand, India were targeted to collect 120 responses from the managers to identify the issues in an unstructured way. For checking the scope of e-applications, a total of 243 respondents were collected randomly from 183 farmers and rest from 60 employees of IT companies who provide supply chain solutions. The result shows that all identified issues are developing positive relationships and provides suggestive IT solutions to them which will help in overall development of farmers involved in sugarcane production.
Variation in colostral immunoglobulin G concentration in fat tailed sheep and evaluation of methods for estimation of colostral immunoglobulin content

In ruminants, colostrum is a vital source of immunoglobulins that provide passive immunity for their offspring during the neonatal period. It is suggested that colostral immunoglobulin G (IgG) concentration varies between and within breeds and could also be affected by maternal factors. The aim of this study was to investigate possible effects of litter type and ewe parturition number on colostral IgG concentration in two Iranian fat-tailed breeds of sheep (Shaul and Lori Bakhtyari) as well as usefulness of different methods for estimation of IgG concentrations in colostrum. The colostral IgG concentrations were measured in 38 Shaul and 59 Lori Bakhtyari ewes by single radial immunodiffusion, zinc sulphate turbidity and Biuret methods. Measurement of IgG by single radial immunodiffusion revealed that Lori Bakhtyari ewes had significantly (P 0.05). The mortality rate was higher in lambs born to ewes with lower IgG in their colostrum. Single radial immunodiffusion did not correlate either with zinc sulphate turbidity method (r = -0.253, P > 0.05) or with Biuret method (r = -0.005, P > 0.05). We can conclude that concentration of colostral IgG could be influenced by breed but not by litter type and parturition number. Colostrum, parturition, litter, radial immunodiffusion, zinc sulphate turbidity, Biuret method Adequate transfer of colostral immunoglobulin (Ig) to newborn lambs is essential as lambs with insufficient amount of antibody are at higher risk of contracting diseases and thus higher mortality rate (Sawyer et al. 1977; Ahmad et al. 2000). The quantity
Gamma-ray Novae: Rare or Nearby?

Classical Novae were revealed as a surprise source of gamma-rays in Fermi LAT observations. During the first 8 years since the LAT was launched, 6 novae in total have been detected to > 5 sigma in gamma-rays, in contrast to the 69 discovered optically in the same period. We attempt to resolve this discrepancy by assuming all novae are gamma-ray emitters, and assigning peak one-day fluxes based on a flat distribution of the known emitters to a simulated population. To determine optical parameters, the spatial distribution and magnitudes of bulge and disc novae in M31 are scaled to the Milky Way, which we approximate as a disc with a 20 kpc radius and elliptical bulge with semi major axis 3 kpc and axis ratios 2:1 in the xy plane. We approximate Galactic reddening using a double exponential disc with vertical and radial scale heights of r_d = 5 kpc and z_d = 0.2 kpc, and demonstrate that even such a rudimentary model can easily reproduce the observed fraction of gamma-ray novae, implying that these apparently rare sources are in fact nearby and not intrinsically rare. We conclude that classical novae with m_R < 12 and within ~8 kpc are likely to be discovered in gamma-rays using the Fermi LAT.