Miracle-dz/UniFAR-FTUs huggingface dataset:
Rigidity, Planning and Autistic Traits in Hoarding Disorder: a Comparative Study between Patients with Hoarding Disorder and Obsessive-Compulsive Disorder

Introduction Hoarding symptoms have been described in patients with obsessive-compulsive disorders (OCD). There are indications that hoarding is related to autism problems rather than to OCD. Therefore, we aimed to investigate the presence of autistic traits, theory of mind and rigidity in patients with hoarding disorder (HD) and compare them to OCD patients without hoarding behavior. Method 34 participants in three groups (HD; mostly without OCD, OCD without hoarding and healthy controls) were tested on autistic traits (AQ; Autism Spectrum Quotient), theory of mind (Faux-pas Test), cognitive flexibility/ rigidity (Intra-/ Extradimensional Set Shifting; ID/EDS, Stroop Color-Word Test), planning (Tower of London; ToL), and obsessive-compulsive personality disorder (OCPD SCID II). Results HD and OCD patients displayed similarly elevated scores on the Obsessive-compulsive Inventory-Revised, on behavioral inhibition scale (BIS) and on AQ total score as well as on 4 of five of the AQ subscales compared to controls. Further, HD patients showed higher percentages of OCPD than both OCD patients and controls, and showed a tendency to perform lower on the neuropsychological task that reflects planning (ToL) compared to OCD and controls. On the Faux-pas test, no between-group differences were shown. Discussion HD patients show no dysfunction with respect to communication problems. However, they reveal similarly elevated scores as OCD patients on OCD symptoms, on behavioral inhibition, on rigidity (reflected in OCPD scores) and on autism symptoms that reflect a lack of cognitive flexibility. This striking overlap between HD and OCD with respect to behavioral inhibition/ lack of flexibility is in contrast with the notion to place hoarding as a distinct disorder in DSM-V, although sample size is too small to draw definite conclusions. More research is needed on the relationship between hoarding, OCPD and OCD.
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

We constructed an infectious molecular clone of acquired immunodeficiency syndrome-associated retrovirus. Upon transfection, this clone directed the production of infectious virus particles in a wide variety of cells in addition to human T4 cells. The progeny, infectious virions, were synthesized in mouse, mink, monkey, and several human non-T cell lines, indicating the absence of any intracellular obstacle to viral RNA or protein production or assembly. During the course of these studies, a human colon carcinoma cell line, exquisitely sensitive to DNA transfection, was identified.
Introducing Nanoelectronics into the Electrical Engineering Curriculum

Engineering programs that have introduced nanotechnology into their curriculum typically add material into core classes or have added a separate set of nanotechnology courses. Increasing the number of courses can be a challenge for colleges with limited resources and faculty and it is not easy to make significant changes to the curriculum all in one step. This paper looks at an alternative that is being introduced at the University of Texas at Tyler. The goal is to introduce nanotechnology into select courses while minimizing changes to the curriculum for ease of adoption. The proposed solution is to introduce nanoscale design concepts into existing classes which teach microelectronic-related topics and where nanotechnology will revolutionize the way these circuits are built in the near future. An advantage of this approach is that the students have a prior context to build upon. They can see how state-of-the art microelectronic circuits are currently designed while comparing and contrasting it with the paradigmatic shift offered by nanoelectronic devices. This juxtaposition of technologies is appropriate since a number of proposed nanoelectronic circuits are built upon similar principles and topologies used in current microelectronic technologies. This paper overviews the initial attempts at such an integration in an introductory digital integrated circuits course. Evaluation of this effort through student selfassessment surveys, concept inventory quizzes, and exam and project scores are reported. Plans to improve upon future offerings are also detailed.
Activities of various cobalamins for Euglena gracilis with reference to vitamin B12 assay with Euglena

Coenzyme B12 and methylcobalamin in water are less active in promoting growth of Euglena gracilis Z strain than the same concentrations of cyanocobalamin and hydroxocobalamin which are equally active. When bound to human serum or human liver homogenate, however, the activities of these four cobalamins do not differ significantly with one exception. The results suggest that the Euglena assay using cyanocobalamin standards is not satisfactory for quantitation of coenzyme B12 and methylcobalamin in water but acceptable when coenzyme B12 and methylcobalamin are bound to serum or liver. Sulphitocobalamin in water is as active as cyanocobalamin and hydroxocobalamin but nitritocobalamin is less active. Factor B, the monocarboxylic acids of cyanocobalamin and hydroxocobalamin, and the dicarboxylic acid of cyanocobalamin in water were inactive.
A system for publishing sensor data on the Semantic Web

The development of sensor technologies in the last years offers support for new applications for the Internet of Things. The availability of the data resulting from sensor networks deployed in different environments is important for a number of advanced services, such as traffic flow prediction and power consumption monitoring. We propose a system for publishing sensor data following the linked data principles and providing hereby integration with the Semantic Web. The main components are the Semantic Enrichment component and the Data Publishing component, while for storing sensor data we use a relational database.
Identification of Shigella invasion genes by isolation of temperature-regulated inv::lacZ operon fusions

Penetration and multiplication within cells of the human colonic epithelium are hallmarks of Shigella spp. pathogenicity. Shigella spp. virulence is regulated by growth temperature. Strains phenotypically virulent when grown at 37 degrees C are phenotypically avirulent when grown at 30 degrees C. The number of genes involved in Shigella spp. pathogenicity and how many virulence genes are temperature regulated are unknown. To facilitate the study of temperature-regulated virulence in Shigella spp. , we employed lacZ operon fusion technology to identify temperature-regulated invasion (inv) genes. Four inv::lacZ fusion mutants were identified and found to be unable to invade HeLa cells. The fusions were located in a region of the 220-kilobase invasion plasmid defined as the minimal amount of DNA required for invasion, and they were controlled by virR, the temperature-dependent virulence gene regulator. Western blot (immunoblot) and Southern hybridization analyses indicated that one of the fusions was located in a known inv gene, ipaB, which encodes one of the major immunogenic peptides of Shigella spp. This ipaB::lacZ operon fusion mutant synthesized a truncated IpaB protein recognized by IpaB-specific monoclonal antibodies. Three of the fusions were within novel genes mapping to regions previously identified as essential for a positive virulence phenotype. Analysis of bacterial surface proteins suggested that the genes marked by these fusions may play a role in the correct surface expression of the ipaB and ipaC gene products.
Improved content addressability through relational data modeling and in-network processing elements

Recent realizations of the ICN principle organize content in a hierarchical namespace. We argue that this addressing mode has shortcomings because a single document could be part of several data collections. For instance, Joe's record of his New York Marathon run might be published as a content object with the name /repo/events/NYmarathon/record1234 but would also fit into /repo/users/Joe/record1234. Even further, the content of documents can be very multifaceted such that not all details -e.g. spacial coordinates, timestamps, rankings- can be made available on the name surface. In this paper we show that CCN-style networks enriched with active elements, i.e. content processing/producing entities, can overcome these problems. Exemplarily, we adopt relational data modeling concepts to organize named data and deploy Named Function Networking to implement content addressability which goes beyond the scope of pure, i.e. passive, CCN.
Narrowband optical parametric amplification measurements in Ga0.5In0.5P photonic crystal waveguides.

We report the first demonstration of narrowband parametric amplification in a chip scale semiconductor waveguide. A dispersion engineered, Ga0.5In0. 5P photonic crystal waveguide with a dispersion function that exhibits two zero crossings was used with a pulsed pump placed in the normal dispersion regime while a tunable probe was scanned on either side of the pump. A peak conversion efficiency of -10 dB was obtained with a peak pump power of only 650 mW. The narrowband nature of the gain spectrum was clearly demonstrated.
Consensus Guidelines for the Management of Abnormal Cervical Cancer Screening Tests and Cancer Precursors

L. Stewart Massad, MD, Mark H. Einstein, MD, Warner K. Huh, MD, Hormuzd A. Katki, PhD, Walter K. Kinney, MD, Mark Schiffman, MD, Diane Solomon, MD, Nicolas Wentzensen, MD, and Herschel W. Lawson, MD, for the 2012 ASCCP Consensus Guidelines Conference FromWashington University School of Medicine, St. Louis, Missouri; Albert Einstein College of Medicine, New York, New York; University of Alabama School of Medicine, Birmingham, Alabama; Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland; The Permanente Medical Group, Sacramento, California; and Emory University School of Medicine, Atlanta, Georgia
Effect of growth hormone on body composition and visceral adiposity in middle-aged men with visceral obesity.

RATIONALE GH replacement in GH-deficient adults results in an improvement in metabolic status. GH might also decrease visceral adiposity in obese adults that are not GH deficient. OBJECTIVE Our objective was to determine the effects of supraphysiological GH therapy on the metabolic syndrome and visceral adiposity in men with low blood levels of IGF-I and the durability of these effects after stopping GH therapy. DESIGN The study was a double-blind, placebo-controlled 6-month intervention trial followed by a blinded follow-up period of 6 months. SUBJECTS Thirty nondiabetic middle-aged men with central adiposity (body mass index > 27 kg/m(2); waist circumference > 102 cm) participated. RESULTS After 6 months of GH therapy, we observed an increase in weight and lean body mass (2.5 +/- 0.6 kg, P < 0.05 compared with baseline and placebo) and 8.8% reduction in visceral adiposity. GH increased resting energy expenditure by 172.5 +/- 41.6 kcal/24 h after 6 months of therapy. Fasting insulin, glucose, and the quantitative insulin sensitivity check index for insulin resistance increased during GH therapy. The effects of GH on fatness and visceral adiposity disappeared shortly after GH withdrawal, but weight remained increased over baseline and when compared with the placebo group (P < 0.05). CONCLUSION These data suggest that GH therapy is associated with small but statistically significant decreases in visceral adiposity and an increase in lean mass and body weight. In viscerally obese subjects, supraphysiological GH administration is not an effective treatment; however, additional studies are needed to evaluate the effects of low-dose, physiological GH treatment.
Detection of abrupt changes of total least squares models and application in fault detection

This paper deals with detection of parameter changes of total least squares and generalized total least squares models and its application in fault detection and isolation. Total least squares and generalized total least squares are frequently used to model processes when all measured process variables are corrupted by disturbances. It is therefore of practical interest to monitor processes and detect faults using the total least squares and generalized total least squares as well. The local approach for detection of abrupt changes is adopted as a computational engine for the change detection. The effectiveness and robustness of the proposed algorithm in fault detection and isolation are demonstrated through Monte Carlo simulations: a pilot-scale experiment and sensor validation of an industrial distillation column.
Immediate and delayed memory recall patterns of chronic hemodialysis adult hispanic patients.

OBJECTIVE To determine the most effective time to administer nutrition education to hemodialysis patients by evaluating memory recall scores before, during, and after treatment. DESIGN Prospective, quasi experimental cohort. SUBJECTS Sixty-two adult Hispanic hemodialysis patients (38 men and 24 women, 29 <65 years of age and 32 >65 years of age). Patients, between 18 and 85 years of age, who have been on hemodialysis at least one month. Patients were literate and able to see and hear without impairment. SETTING Hemodialysis clinic. INTERVENTION Fifteen simple words (English and Spanish) in large print on 5 x 8 laminated 2-sided cards that were shown to the patient before, during, and after dialysis. METHODS Patients were shown 5 different words before going on dialysis, 5 more words during dialysis, and 5 more words after dialysis. Each time, the patient was asked for immediate recall to assess short-term memory recall. Patients were then asked 5 to 10 minutes later (before, during, and after dialysis) what words were seen to assess long-term memory recall. MAIN OUTCOME MEASURE Did patients remember more before, during, or after dialysis? RESULTS There were no significant differences in memory recall scores between diabetic and nondiabetic subjects or by gender with respect to memory recall scores. Results imply that time of recall in relation to dialysis treatment may be important for those above 65 years of age. A significant difference was found when comparing those subjects completing elementary school to those subjects completing high school and college. The evidence found in this study was in accordance with the findings of Smith and Winslow in their 1990 study showing subjects required less time to complete a task measuring cognitive function when it was given before hemodialysis treatment, as compared with during the treatment. CONCLUSION As age increases, recall ability likely will decrease. As education level increases, recall ability will likely increase. Providing nutrition education before the hemodialysis treatment occurs may be more beneficial than during and after the treatment. The educational information that a hemodialysis patient retains after treatment may be seriously impacted by the patient's education level and age.
Towards Multi-Objective Optimization for UI Design

In recent years computational optimization has been applied to the problem of finding good designs for user interfaces with huge design spaces. There, designers are struggling to integrate many different objectives into the design process, such as ergonomics, learnability or performance. However, most computationally designed interfaces are optimized with respect to only one objective. In this paper we argue that multi-objective optimization is needed to improve over manual designs. We identify 8 categories that cover design principles from UI design and usability engineering. We propose a multi-objective function in form of a linear combination of these factors and discuss benefits and pitfalls of multi-objective optimization.
SkyView: a user evaluation of the skyline operator

The skyline operator has recently emerged as an alternative to ranking queries. It retrieves a number of potential best options for arbitrary monotone preference functions. The success of this operator in the database community is based on the belief that users benefit from the limited effort required to specify skyline queries compared to, for instance, ranking. While application examples of the skyline operator exist, there is no principled analysis of its benefits and limitations in data retrieval tasks. Our study investigates the degree to which users understand skyline queries, how they specify query parameters and how they interact with skyline results made available in listings or map-based interfaces.
An Unusual, His-dependent Family I Pyrophosphatase from Mycobacterium tuberculosis*

Soluble inorganic pyrophosphatases (PPases) comprise two evolutionarily unrelated families (I and II). These two families have different specificities for metal cofactors, which is thought to be because of the fact that family II PPases have three active site histidines, whereas family I PPases have none. Here, we report the structural and functional characterization of a unique family I PPase from Mycobacterium tuberculosis (mtPPase) that has two His residues (His21 and His86) in the active site. The 1.3-Å three-dimensional structure of mtPPase shows that His86 directly interacts with bound sulfate, which mimics the product phosphate. Otherwise, mtPPase is structurally very similar to the well studied family I hexameric PPase from Escherichia coli, although mtPPase lacks the intersubunit metal binding site found in E. coli PPase. The cofactor specificity of mtPPase resembles that of E. coli PPase in that it has high activity in the presence of Mg2+, but it differs from the E. coli enzyme and family II PPases because it has much lower activity in the presence of Mn2+ or Zn2+. Replacements of His21 and His86 in mtPPase with the residues found in the corresponding positions of E. coli PPase had either no effect on the Mg2+- and Mn2+-supported reactions (H86K) or reduced Mg2+-supported activity (H21K). However, both replacements markedly increased the Zn2+-supported activity of mtPPase (up to 11-fold). In the double mutant, Zn2+ was a 2.5-fold better cofactor than Mg2+. These results show that the His residues in mtPPase are not essential for catalysis, although they determine cofactor specificity.
New clinical research strategies in thoracic oncology: clinical trial design, adaptive, basket and umbrella trials, new end-points and new evaluations of response

In the genomics era, our main goal should be to identify large and meaningful differences in small, molecularly selected groups of patients. Classical phase I, II and III models for drug development require large resources, limiting the number of experimental agents that can be tested and making the evaluation of targeted agents inefficient. There is an urgent need to streamline the development of new compounds, with the aim of identifying “trials designed to learn”, which could lead to subsequent “trials designed to conclude”. Basket trials are often viewed as parallel phase II trials within the same entity, designed on the basis of a common denominator, which can be a molecular alteration(s). Most basket trials are histology-independent and aberration-specific clinical trials. Umbrella trials are built on a centrally performed molecular portrait and molecularly selected cohorts with matched drugs, and can include patients’ randomisation and strategy validation. Beyond new designs, new end-points and new evaluation techniques are also warranted to finally achieve methodology and clinical improvements, in particular within immunotherapy trials.
Factors Associated with Intellectual Development: Birth Order and Family Size Effects for a Select Population

This Dissertation is brought to you for free and open access by the Theses and Dissertations at Loyola eCommons. It has been accepted for inclusion in Dissertations by an authorized administrator of Loyola eCommons. For more information, please contact ecommons@luc.edu. all of whom contributed to the ultimate completion of this task. Particular gratitude goes to the committee Director, Dr. Joy Rogers who has been a continuing source of encouragement as well as a model for academic excellence. Cook County Juvenile Temporary Detention Center, without whose understanding and cooperation this task would have been considerably more difficult. Most importantly I wish to express my gratitude to my wife, Deanne, to whom, and with whom, all things are possible. was graduated in 1963.
A TAXONOMIC REVISION OF FOSSIL FRESHWATER PEARL MUSSELS (BIVALVIA: UNIONOIDA: MARGARITIFERIDAE) FROM PLIOCENE AND PLEISTOCENE DEPOSITS OF SOUTHEASTERN EUROPE

Margaritiferidae is an ancient freshwater bivalve family originated in the Jurassic in East Asia. Here, we revise several nominal taxa of fossil freshwater pearl mussels that were recovered from the Upper Pliocene and Pleistocene deposits of the Dniester and Prut river valleys. Based on morphological and stratigraphic data, we found that these nominal taxa belong to the genus Pseudunio and are junior synonyms of P. flabellatiformis (Grigorowitch-Beresowski, 1915). The new synonymy is proposed as follows: Margaritifera (Pseudunio) moldavica Chepalyga, 1964 syn. nov., Margaritifera (Pseudunio) robusta robusta Chepalyga, 1964 syn. nov., Margaritifera (Pseudunio) robusta speensis Chepalyga, 1964 syn. nov., and Margaritifera (Pseudunio) robusta tirassica Chepalyga, 1964 syn. nov. All these fossil nominal taxa were described based on minor differences in the shell shape and size, hinge structure, and stratigraphic position. Finally, we suggest an updated phylogenetic scheme of the genus Pseudunio, which contains five valid species: P. marocanus (Pallary, 1918) [Eocene – Recent, Morocco], P. auricularius (Spengler, 1793) [Pliocene – Recent, Southern and Western Europe], P. homsensis (Lea, 1865) [Pliocene – Recent, Orontes and Nahr al-Kabir basins], P. flabellatiformis (Grigorowitch-Beresowski, 1915) comb. rev. [Pliocene – Late Pleistocene, paleo-Dniester and paleo-Danube basins, an extinct lineage related to P. auricularius and P. homsensis], and P. flabellatus (Goldfuss, 1837) comb. rev. [Miocene, paleo-Danube Basin, a stem lineage, MRCA of P. auricularius - P. homsensis clade].
Meteorites on Mars observed with the Mars Exploration Rovers

[1] Reduced weathering rates due to the lack of liquid water and significantly greater typical surface ages should result in a higher density of meteorites on the surface of Mars compared to Earth. Several meteorites were identified among the rocks investigated during Opportunity's traverse across the sandy Meridiani plains. Heat Shield Rock is a IAB iron meteorite and has been officially recognized as “Meridiani Planum. ” Barberton is olivine-rich and contains metallic Fe in the form of kamacite, suggesting a meteoritic origin. It is chemically most consistent with a mesosiderite silicate clast. Santa Catarina is a brecciated rock with a chemical and mineralogical composition similar to Barberton. Barberton, Santa Catarina, and cobbles adjacent to Santa Catarina may be part of a strewn field. Spirit observed two probable iron meteorites from its Winter Haven location in the Columbia Hills in Gusev Crater. Chondrites have not been identified to date, which may be a result of their lower strengths and probability to survive impact at current atmospheric pressures. Impact craters directly associated with Heat Shield Rock, Barberton, or Santa Catarina have not been observed, but such craters could have been erased by eolian-driven erosion.