Miracle-dz/UniFAR-FTUs huggingface dataset:
IDE 2.0: collective intelligence in software development

Today's Integrated Development Environments (IDEs) only integrate the tools and knowledge of a single user and workstation. This neglects the fact that the way in which we develop and maintain a piece of software and interact with our IDE provides a rich source of information that can help ourselves and other programmers to avoid mistakes in the future, or improve productivity otherwise. We argue that, in the near future, IDEs will undergo a revolution that will significantly change the way in which we develop and maintain software, through integration of collective intelligence, the knowledge of the masses. We describe the concept of an IDE based on collective intelligence and discuss three example instantiations of such IDEs.
Job satisfaction among general practitioners: A systematic literature review

Objective: In recent years, the incidence of being overworked and burnt out has increased among general practitioners (GPs). One of the factors that influences the development of burnout is the job satisfaction that physicians experience. Therefore, we conducted a literature review to answer the question: what factors influence the job satisfaction experienced by GPs? Methods: We used two methods to retrieve citations. We searched four literature databases for citations from 1990 until July 2006, and we checked the reference lists of relevant articles. The inclusion criteria were: GPs had to be the subjects of the study, the study had to describe empirical research, the study had to focus on job satisfaction, and the number of subjects had to be greater than 30. Results: We found 24 relevant citations. Factors increasing job satisfaction which were mentioned more than twice were: diversity of work, relations and contact with colleagues, and being involved in teaching medical students. Factors decreasing job satisfaction were: low income, too many working hours, administrative burdens, heavy workload, lack of time, and lack of recognition. Conclusion: Aspects of job satisfaction concerning the content of the profession seem to increase job satisfaction, and aspects concerning employment conditions seem to decrease job satisfaction.
ARABIS: An asynchronous acoustic indoor positioning system for mobile devices

Acoustic ranging based indoor positioning solutions have the advantage of higher ranging accuracy and better compatibility with commercial-off-the-self consumer devices. However, similar to other time-domain based approaches using Time-of-Arrival and Time-Difference-of-Arrival, they suffer from performance degradation in presence of multi-path propagation and low received signal-to-noise ratio (SNR) in indoor environments. In this paper, we improve upon our previous work on asynchronous acoustic indoor positioning and develop ARABIS, a robust and low-cost acoustic positioning system (IPS) for mobile devices. We develop a low-cost acoustic board custom-designed to support large operational ranges and extensibility. To mitigate the effects of low SNR and multi-path propagation, we devise a robust algorithm that iteratively removes possible outliers by taking advantage of redundant TDoA estimates. Experiments have been carried in two testbeds of sizes 10.67m × 7.76m and 15m × 15m, one in an academic building and one in a convention center. The proposed system achieves average and 95% quantile localization errors of 7.4cm and 16.0cm in the first testbed with 8 anchor nodes and average and 95% quantile localization errors of 20.4cm and 40.0cm in the second testbed with 4 anchor nodes only.
The Conserved Dcw Gene Cluster of R. sphaeroides Is Preceded by an Uncommonly Extended 5’ Leader Featuring the sRNA UpsM

Cell division and cell wall synthesis mechanisms are similarly conserved among bacteria. Consequently some bacterial species have comparable sets of genes organized in the dcw (division and cell wall) gene cluster. Dcw genes, their regulation and their relative order within the cluster are outstandingly conserved among rod shaped and gram negative bacteria to ensure an efficient coordination of growth and division. A well studied representative is the dcw gene cluster of E. coli. The first promoter of the gene cluster (mraZ1p) gives rise to polycistronic transcripts containing a 38 nt long 5’ UTR followed by the first gene mraZ. Despite reported conservation we present evidence for a much longer 5’ UTR in the gram negative and rod shaped bacterium Rhodobacter sphaeroides and in the family of Rhodobacteraceae. This extended 268 nt long 5’ UTR comprises a Rho independent terminator, which in case of termination gives rise to a non-coding RNA (UpsM). This sRNA is conditionally cleaved by RNase E under stress conditions in an Hfq- and very likely target mRNA-dependent manner, implying its function in trans. These results raise the question for the regulatory function of this extended 5’ UTR. It might represent the rarely described case of a trans acting sRNA derived from a riboswitch with exclusive presence in the family of Rhodobacteraceae.
Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance

In previous studies we showed that a chronic colitis associated with a Th1 T cell response can be induced by the rectal administration of the haptenizing reagent 2,4,6-trinitrobenzene sulfonic acid (TNBS). We report here that oral administration of haptenized colonic proteins (HCP) before rectal administration of TNBS effectively suppresses the ability of the latter to induce colitis. This suppression (oral tolerance) appears to be due to the generation of mucosal T cells producing TGF-beta and Th2-type cytokines after oral HCP administration. Peyer's patch and lamina propria CD4+ T cells from HCP- fed animals stimulated with anti-CD3/anti-CD28 had a 5-10-fold increase in their production of TGF-beta and secreted increased amounts of IL-4 and IL-10 but lower levels of IFN-gamma in comparison to T cells from ovalbumin-fed control animals. In addition, the colons of HCP-fed mice showed strikingly increased TGF-beta but decreased IL-12 expression by immunohistochemical studies and isolated mononuclear cells from HCP-fed animals secreted less IL-12 heterodimer. Finally, and most importantly, the suppressive effect of orally administered HCP was abrogated by the concomitant systemic administration of anti-TGF-beta or rIL-12 suggesting a reciprocal relationship between IL-12 and TGF-beta on tolerance induction in TNBS-induced colitis. In parallel studies we demonstrated that TNBS-induced colitis can be transferred to naive recipient animals with purified CD4+ T cells from the colon of TNBS- treated animals and that such animals develop lethal pancolitis when exposed to very low doses of TNBS. Feeding of HCP suppressed this sensitivity to TNBS, indicating that oral feeding can suppress the response of pre-committed T cells in vivo. These studies suggest for the first time that TGF-beta production can abrogate experimental granulomatous colitis even after such colitis is established, and thus, that regulation of TGF-beta levels may have relevance to the treatment of human inflammatory bowel disease.
Prognostic factors in adult patients up to 60 years old with acute myeloid leukemia and translocations of chromosome band 11q23: individual patient data-based meta-analysis of the German Acute Myeloid Leukemia Intergroup.

PURPOSE To identify risk factors for induction success and overall survival (OS) and relapse-free survival (RFS) and to evaluate the impact of allogeneic stem-cell transplantation (alloSCT) in adult patients up to 60 years old with acute myeloid leukemia (AML) and reciprocal translocations involving chromosome band 11q23 [t(11q23)]. PATIENTS AND METHODS An individual patient data-based meta-analysis was performed on 180 adult patients with AML and t(11q23). These patients were identified by cytogenetics and/or molecular techniques and treated within eight prospective multicenter trials of the German AML Intergroup. The median follow-up time was 53 months. RESULTS Complete remission rate was 71%. Favorable factors for induction success were the presence of a t(9;11), t(11q23) as a sole aberration, and de novo leukemia. OS rate at 4 years was 29%. Translocations other than t(9;11), platelets less than the median, secondary leukemia, and peripheral blasts greater than the median were adverse risk factors for OS. RFS rate at 4 years was 29%. The presence of a t(6;11) and peripheral blasts greater than the median had a negative impact on RFS. Three risk groups for OS and RFS could be defined by the combination of these factors with 4-year OS rates of 50%, 28%, and 5% and 4-year RFS rates of 37%, 26%, and 5%. An alloSCT from matched related or unrelated donors in first complete remission was beneficial, especially in t(6;11)-negative patients. CONCLUSION Risk stratification of AML patients with reciprocal translocations of chromosome band 11q23 is feasible based on the translocation partner and clinical parameters.
Comparison between meloxicam and transdermally administered fentanyl for treatment of postoperative pain in dogs undergoing osteotomy of the tibia and fibula and placement of a uniplanar external distraction device.

OBJECTIVE To compare the efficacy of meloxicam administered perioperatively with transdermal administration of fentanyl via a patch placed preoperatively in dogs undergoing orthopedic surgery. DESIGN Prospective study. ANIMALS 16 dogs. PROCEDURE Unilateral or bilateral osteotomy of the tibia and fibula was surgically performed, and a uniplanar external distraction device was placed in each limb. Postoperative pain and lameness were assessed 24, 48, and 72 hours after administration of the first of 3 doses of meloxicam (0.2 mg/kg [0.09 mg/lb], IV, given preoperatively, followed by 0.1 mg/kg [0.045 mg/lb], IV, after 24 hours, and 0.1 mg/kg, PO, after 48 hours) or preoperative placement of a transdermal fentanyl patch (50 microg/h) left in place for 72 hours. RESULTS No significant differences in total pain scores were detected between groups. Mean +/- SD lameness scores assessed at 24 and 72 hours were lower in dogs in the meloxicam group than dogs in the fentanyl group. Lameness scores decreased with time in a similar manner in both treatment groups. CONCLUSIONS AND CLINICAL RELEVANCE Perioperative administration of meloxicam or preoperative placement of a transdermal fentanyl patch provided effective and similar postoperative analgesia in dogs undergoing orthopedic surgery. However, because of its anti-inflammatory effects, treatment with meloxicam reduced the degree of lameness and resulted in rapid functional recovery of the limb.
Changes in cation transport and (Na + K)-activated adenosine triphosphatase produced by chronic administration of ethanol.

Chronic administration of ethanol to rats, in a dosage which was previously found to produce acquired behavioral tolerance, resulted in an increase in the rate of K + and Rb 86 accumulation by brain cortex slices incubated in vitro . There was also an increase in (Na + K)-stimulated adenosine triphosphatase activity as measured in brain homogenates. Cessation of alcohol treatment was followed by a return of the rate of cation transport to normal values in about the same time as has previously been observed for the disappearance of acquired tolerance. There was no difference in the inhibitory effect of ethanol added in vitro on the rate of cation transport in brain slices from control and alcohol-treated animals. In the erythrocytes of human alcoholics, Rb 86 uptake and membrane (Na + K)-adenosine triphosphatase activity were both increased above normal values. The changes in cation transport and adenosine triphosphatase activity are interpreted as adaptive changes resulting from chronic intake of ethanol.
Optically-regulated impedance-based balancing for humanoid robots

This paper attempts to resolve the issue of regulating a humanoid robot's impedance levels and Centre-of-Mass (CoM) position, for the purpose of maintaining balance, by means of receiving visual feedback from its environment. Once it has been endowed with visual perception, the robot is rendered capable of ascertaining whether a moving object located within fair proximity to its structure could potentially menace its state of balance, based on its relative distance and velocity. The real-time detection of such an event then necessitates the performance of a preparative action that would serve the purpose of ensuring the system's timely balancing. However, the latter may be viewed as a twofold problem in this context, since in addition to triggering a motion aimed at transferring the CoP towards the side of the polygon at which an external impact is imminent, the robot's impedance also needs to vary appropriately in order to absorb this disturbance. Experimental results obtained using a depth ASUS Xtion PRO Live camera attached to the COmpliant huMANoid (COMAN), clearly demonstrate the balance augmentation that is achievable when incorporating visual feedback into a balancing controller, thus partially corroborating the generic hypothesis that visual perception could potentially pave the way for a bipedal robot's emulation of human-like balancing.
Granulomatous Arteritis with Massive Eosinophilic Leukocyte Infiltration and Transient Peripheral Eosinophilia Subsequent to Transarterial Embolization Therapy with a Gelatin Sponge

A 38‐year old man presented with a cavernous hemangioma in the liver. Transarterial embolization (TAE) using a gelatin sponge was carried out 14 days prior to surgical resection of the tumor. Granulomatous arteritis with massive infiltration by eosinophilic leukocytes and histiocytes was present at the periphery of the hemangioma, and transient eosinophilia in the peripheral blood occurred six days after resection. Granulomatous arteritis was evident in medium‐sized arteries and there was narrowing or occlusion of the vascular lumen. In the granulomatous cellular infiltrates in the arteries, giant cells of the foreign body type were numerous. An eosinophilic substance differing from fibrin was present in some of the vascular lumina. As this showed staining for collagen, it was considered likely to be fragments of the gelatin sponge. The patient had no symptoms of fever, chills or general fatigue. The clinical course and pathologic findings suggest a causative role of the gelatin sponge in this case of granulomatous arteritis. Vascular change, a rare complication of TAE therapy, may be induced by a hypersensitivity reaction against the intraarterial gelatin sponge. Acta Pathol Jpn 41: 618‐622, 1991.
The complexity of TRMCS-like spiral specification

Modern software is often constructed using "spiral specification"; i.e. the specification is a dynamic document that is altered by experience with the current version of the system. Mathematically, many of the sub-tasks within spiral specification belong to the NP-complete class of tasks. In the traditional view of computer science, such tasks are fundamentally intractable and only solvable using incomplete, approximate methods that can be undependable. This traditional view suggests that we should routinely expect spiral specification to always be performed very poorly. This paper is an antidote to such pessimism. Contrary to the traditional view, we can expect that spiral specification can usually be performed adequately, providing that analysts augment their current tools with random probing.
COMIC: Intelligent Contention Window Control for Distributed Medium Access

In this letter, a scheme for Collision Mitigation with Intelligent Contention Window Control (COMIC) is proposed for backoff based collision resolution algorithm. COMIC intelligently mitigates collisions by probabilistically maximizing the selection likelihood of relatively less collision-probable contention slots over the backoffed contention window. A unified Markovian model for the Distribution Coordination Function (DCF) that incorporates COMIC, DCFcomic, is formulated for the performance analysis. The performance results show that DCFcomic outperforms the conventional DCF in both throughput and average packet delay due to the significant reduction in packet collisions.
Development of hairy cell leukemia in familial platelet disorder with predisposition to acute myeloid leukemia

Abstract Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) is an autosomal dominant disorder characterized by mild to moderate thrombocytopenia with or without its impaired function, inherited RUNX1 mutation and high incidence of myeloid malignancy, such as myelodysplastic syndrome or acute myeloid leukemia. A 72-year-old male visited our institute because of gradually progressive pancytopenia and splenomegaly, and was diagnosed as having hairy cell leukemia. He was administered one course of intravenous cladribine (0.12 mg/kg, day 1–5) and achieved hematological complete response. Mutation analyses of RUNX1 gene were underwent because familial history of hematological malignancies evoked a possibility of FPD/AML. As a result, RUNX1 L445P mutation was identified in the peripheral blood and the mutation was considered as germ-line mutation because the same mutation was detected in the buccal mucosa. BRAF V600E mutation was also identified in the peripheral blood but not in the buccal mucosa. To our knowledge, this is the first report of B cell malignancy arising from FPD/AML.
Cooperative Caching for Chip Multiprocessors

This paper presents CMP cooperative caching, a unified framework to manage a CMP's aggregate on-chip cache resources. Cooperative caching combines the strengths of private and shared cache organizations by forming an aggregate "shared" cache through cooperation among private caches. Locally active data are attracted to the private caches by their accessing processors to reduce remote on-chip references, while globally active data are cooperatively identified and kept in the aggregate cache to reduce off-chip accesses. Examples of cooperation include cache-to-cache transfers of clean data, replication-aware data replacement, and global replacement of inactive data. These policies can be implemented by modifying an existing cache replacement policy and cache coherence protocol, or by the new implementation of a directory-based protocol presented in this paper. Our evaluation using full-system simulation shows that cooperative caching achieves an off-chip miss rate similar to that of a shared cache, and a local cache hit rate similar to that of using private caches. Cooperative caching performs robustly over a range of system/cache sizes and memory latencies. For an 8-core CMP with 1MB L2 cache per core, the best cooperative caching scheme improves the performance of multithreaded commercial workloads by 5-11% compared with a shared cache and 4-38% compared with private caches. For a 4-core CMP running multiprogrammed SPEC2000 workloads, cooperative caching is on average 11% and 6% faster than shared and private cache organizations, respectively
A traffic-aware controller design for next generation software defined networks

The tremendous increase in the mobile traffic requirements and the growing demands of large scale Cloud data centers have lead the network administrators to seek new management approaches. The Software Defined Networks (SDN) has raised as a promising solution providing more effective, programmable and granular configurations in order to isolate all the dynamic traffic requirements and spiky changes in the physical topological status of the networks from the network management. In this paper, we propose a novel SDN Controller which classifies the network traffic types according to the heterogeneous Quality of Service requirements that the network data is separated into the Constant Bit Rate (CBR) based realtime traffic and File Transfer Protocol (FTP) based non-real time traffic. Some crucial traffic flow parameters such as packet delivery ratio, routing overhead and delay are also considered in this classification. A novel protocol header is also generated by the proposed SDN controller in order to disseminate the necessary information through the L2/L3 switches in the Data Plane. This header is composed of the Parameter, Rule, Controller Action subfields. The proposed SDN controller decides the most effective network deployment strategy, i.e. either becoming an ad-hoc or being centralized, using the traffic types, network parameters and the header information. A detailed performance evaluation is provided which indicates the efficiency of the proposed SDN controller while deciding necessary deployment considering the heterogeneous traffic types as well as the increased number of users in the topology.
Biometric evaluation of anterior chamber changes after physiologic pupil dilation using Pentacam and anterior segment optical coherence tomography.

PURPOSE We evaluated changes in anterior chamber (AC) morphology and iris volume induced by physiological mydriasis in fellow eyes of acute angle-closure patients, and age-, sex-, and central AC depth-matched primary angle-closure suspects (PACS). METHODS In our study, 21 fellow eyes of patients with acute angle closure; 40 age-, sex-, and central AC depth-matched PACS eyes; and 40 age- and sex-matched normal open-angle eyes were imaged using a Pentacam and anterior segment optical coherence tomography (AS-OCT) under light conditions, and after 5 minutes of darkness using AS-OCT. Iris volume was estimated using AS-OCT and a customized image-processing software. RESULTS Central AC depth, corneal curvature, axial length, and lens thickness did not differ significantly between the PACS and fellow eyes. When going from light to dark, angle opening distance at 500 μm decreased significantly more in fellow eyes than in PACS (-68% vs. -52%, P < 0.001). When going from light to dark, the mean iris volume increased significantly in the fellow eyes (from 45.34 ± 2.1 to 47.68 ± 3.2 mm(3), P < 0.01), whereas it decreased significantly in most PACS eyes (from 45.01 ± 2.2 to 42.11 ± 2.3 mm(3), P < 0.01), and in all open-angle eyes (from 44.68 ± 1.16 to 41.67 ± 1.20 mm(3), P < 0.01). Based on multivariate analysis, significant predictors of angle narrowing under darkness (relative change in angle-opening distance 500) were fellow eyes compared to PACS (β = -2.98, SE = 0.249, P = 0.005) and higher iris volume increase with pupil dilation (β = -3.146, SE = 0.432, P = 0.015). CONCLUSIONS Under dark conditions, angles of fellow eyes closed dramatically more than did those of PACS. Iris volume increase per millimeter of pupil dilation is an independent predictor of angle narrowing in darkness.
After the change : How work role changes affect job satisfaction, turnover intention and general health.

This study examined the role of people’s changing work roles and choice of work position for job satisfaction, turnover intention and general health after organizational change. Participants were 131 government agency managers undergoing a change of the management structure whereupon manager positions were cut down and everyone had to re-apply for the positions they wanted. Questionnaire data was collected before the organizational change and afterwards, when 43 of the participants were no longer managers. Four groups were formed from a combination of getting first choice of position or not and transferring down or not. A repeated measures ANOVA showed that the combination of not getting first choice of position and downward transfer resulted in significantly larger decrease in job satisfaction, larger increase in turnover intention and bigger decrease in general health than all other combinations. Practical implications for human resources management are discussed.