Miracle-dz/UniFAR-FTUs huggingface dataset:
Named Series : Neropeptide Regulation of Immunity Treatment with a-melanocyte stimulating hormone preserves calcium regulatory proteins in rat heart allografts

Prevention of graft dysfunction is a major objective in transplantation medicine. Previous research on experimental heart transplantation indicated that treatment with the immunomodulatory peptide a-melanocyte stimulating hormone (a-MSH) improves histopathology, prolongs allograft survival, and reduces expression of the main tissue injury mediators. Because calcium-handling is critical in heart graft function, we determined the effects of transplantation injury and influences of a-MSH treatment on representative calcium regulatory proteins in rat heart allografts. Hearts from Brown Norway rats were transplanted heterotopically into MHC incompatible Lewis rats. Ca/calmodulin-dependent protein kinase II (CaMKII), protein kinase C e (PKCe), sarcoplasmic/endoplasmic reticulum calciumATPase 2 (SERCA2a), arrestin-b1 (Arrb1), cholinergic receptor M2 (Chrm2), and inositol 1,4,5-triphosphate receptor 1 (InsP3R1) were examined in: (1) non-transplanted donor hearts; (2) allografts from saline-treated rats; and (3) allografts from rats treated with the synthetic a-MSH analog Nle4-DPhe7-a-MSH (NDP-a-MSH) (100 lg i.p. every 12 h). Transplantation injury was associated with severe reduction in calcium regulatory protein transcription and expression level. NDP-a-MSH administration partly reversed inhibition of protein transcription and almost completely prevented protein loss. Finally, because certain effects of cyclic 3 0-5 0-adenosine monophosphate (cAMP) signaling on calcium handling in cardiac myocytes depend on activation of exchange protein directly activated by cAMP 1 (Epac1), we determined Epac1 mRNA and protein expression in heart allografts. Transplantation injury markedly reduced Epac1. NDPa-MSH treatment significantly preserved both Epac1 protein and mRNA in the allografts. Administration of a-MSH or related melanocortins could reduce transplantation-induced dysfunction through protection of heart calcium regulatory proteins. 2007 Elsevier Inc. All rights reserved.
JM-Net and Cluster-SVM for Aerial Scene Classification

Aerial scene classification, which is a fundamental problem for remote sensing imagery, can automatically label an aerial image with a specific semantic category. Although deep learning has achieved competitive performance for aerial scene classification, training the conventional neural networks with aerial datasets will easily stick in overfitting. Because the aerial datasets only contain a few hundreds or thousands images, meanwhile the conventional networks usually contain millions of parameters to be trained. To address the problem, a novel convolutional neural network named Justify Mentioned Net (JM-Net) is proposed in this paper, which has different size of convolution kernels in same layer and ignores the fully convolution layer, so it has fewer parameters and can be trained well on aerial datasets. Additionally, Cluster-SVM, a strategy to improve the accuracy and speed up the classification is used in the specific task. Finally, our method surpass the state-of-art result on the challenging AID dataset while cost shorter time and used smaller storage space.
StrassenNets: Deep learning with a multiplication budget

A large fraction of the arithmetic operations required to evaluate deep neural networks (DNNs) consists of matrix multiplications, in both convolution and fully connected layers. We perform end-to-end learning of low-cost approximations of matrix multiplications in DNN layers by casting matrix multiplications as 2-layer sum-product networks (SPNs) (arithmetic circuits) and learning their (ternary) edge weights from data. The SPNs disentangle multiplication and addition operations and enable us to impose a budget on the number of multiplication operations. Combining our method with knowledge distillation and applying it to image classification DNNs (trained on ImageNet) and language modeling DNNs (using LSTMs), we obtain a first-of-a-kind reduction in number of multiplications (over 99.5%) while maintaining the predictive performance of the full-precision models. Finally, we demonstrate that the proposed framework is able to rediscover Strassen's matrix multiplication algorithm, learning to multiply $2 \times 2$ matrices using only 7 multiplications instead of 8.
Thymidylate Synthesis and Aminopterin Resistance in Bacillus subtilis

Wilson, Melba Carr (Brown University, Providence, R.I.), James L. Farmer, and Frank Rothman. Thymidylate synthesis and aminopterin resistance in Bacillus subtilis. J. Bacteriol. 92:186–196. 1966. —The thymine-requirement of Bacillus subtilis 168 thy results from mutation in two unlinked genes (i.e., genetic loci) designated thyA and thyB. The thyB gene is located between the met and ile markers. Both thyA+thyB and thyA thyB+ strains are phenotypically thy+. ThyA+thyB strains resemble the wild type in their sensitivity to aminopterin, poor incorporation of exogenous thymine into deoxyribonucleic acid (DNA), and high level of thymidylate synthetase activity in crude extracts. ThyA thyB+ strains are resistant to aminopterin in the presence of thymine, incorporate exogenous thymine into DNA, and have no detectable thymidylate synthetase activity. Experiments designed to elucidate the role of the thyB gene indicate that it specifies an alternate pathway of thymidylate synthesis, similar to thymidylate synthetase but requiring a cofactor other than tetrahydrofolate. The mechanism of selection of thymine-requiring mutants by aminopterin is revealed by these results.
Flexible Stereospecific Interactions and Composition within Nucleoprotein Complexes Assembled on the TCRα Gene Enhancer1

During thymocyte maturation, enhancers of genes encoding for TCRδ (Tcrd) and TCRα (Tcra), Eδ8, and Eα, work as a developmental switch controlling transition from Tcrd to Tcra activity at the Tcrad locus. Previous experiments revealed that an Eα fragment, Tα1-Tα2, which constitutes a well-characterized compact nucleoprotein structure led to premature activation of V(D)J recombination compared with that observed for the entire Eα or Tα1-Tα4. These experiments indicated that Tα3-Tα4 collaborates with factors bound to Tα1-Tα2 for the strict developmental regulation of Tcra rearrangement. The compact enhanceosome created on Tα1-Tα2 explained the molecular basis for requirement of intact Tα2 TCF/LEF and ets sites for enhancer function. We have created a mutant version of Eα, EαMC, in which Eδ myb and runx sites have been substituted for Tα2 runx and ets sites, that argues against the notion of a requirement for strict Eα enhanceosome structure for function. EαMC resulted in a very potent enhancer indicating that stereospecific interactions among proteins that form an Eα enhanceosome are rather flexible. Activation of V(D)J recombination by EαMC during thymocyte development resulted, however, to be premature and indistinguishable from that of Tα1-Tα2. These results indicate that Tα3-Tα4 itself is not sufficient to impart a developmental delay to a chimeric “early” enhancer, and indicate the need for functional collaboration between Tα2 runx/ets sites binding proteins and proteins bound to Tα3-Tα4 for proper developmental activation. The possibility of assembly of distinct sets of proteins on Eα might represent a more flexible form of information processing during thymocyte development.
N ε-(Carboxymethyl)Lysine Adducts of Proteins Are Ligands for Receptor for Advanced Glycation End Products That Activate Cell Signaling Pathways and Modulate Gene Expression*

Recent studies suggested that interruption of the interaction of advanced glycation end products (AGEs), with the signal-transducing receptor receptor for AGE (RAGE), by administration of the soluble, extracellular ligand-binding domain of RAGE, reversed vascular hyperpermeability and suppressed accelerated atherosclerosis in diabetic rodents. Since the precise molecular target of soluble RAGE in those settings was not elucidated, we tested the hypothesis that predominant specific AGEs within the tissues in disorders such as diabetes and renal failure,N ε-(carboxymethyl)lysine (CML) adducts, are ligands of RAGE. We demonstrate here that physiologically relevant CML modifications of proteins engage cellular RAGE, thereby activating key cell signaling pathways such as NF-κB and modulating gene expression. Thus, CML-RAGE interaction triggers processes intimately linked to accelerated vascular and inflammatory complications that typify disorders in which inflammation is an established component.
Fractional envelope analysis for rolling element bearing weak fault feature extraction

The bearing weak fault feature extraction is crucial to mechanical fault diagnosis and machine condition monitoring. Envelope analysis based on Hilbert transform has been widely used in bearing fault feature extraction. A generalization of the Hilbert transform, the fractional Hilbert transform is defined in the frequency domain, it is based upon the modification of spatial filter with a fractional parameter, and it can be used to construct a new kind of fractional analytic signal. By performing spectrum analysis on the fractional envelope signal, the fractional envelope spectrum can be obtained. When weak faults occur in a bearing, some of the characteristic frequencies will clearly appear in the fractional envelope spectrum. These characteristic frequencies can be used for bearing weak fault feature extraction. The effectiveness of the proposed method is verified through simulation signal and experiment data.
Effect of VP12 and viperistatin on inhibition of collagen receptors: dependent melanoma metastasis

Viperistatin and VP12 isolated from Vipera paleastinae venom showed a potent inhibitory activity against collagen receptors, α1β1 and α2β1 integrins, respectively. Structurally, viperistatin belongs to the disintegrin family of proteins, whereas VP12 is composed of two subunits VP12A and VP12B displaying amino acid sequence homology with heterodimeric C- lectin type proteins. Viperistatin and VP12 used separately and simultaneously inhibited pro- metastatic activities of melanoma cells lines. The level of inhibition of MV3 and HS.939T human cell lines in cell adhesion and migration assays by both compounds was correlated with expression of α1β1 and α2β1 integrins on the cell surface. MV3 cells express collagen receptors to much higher extent than HS.939T and required the application of higher concentrations of inhibitors to block their adhesion to collagen types I and IV. A melanoma cell transmigration assay through a dHMVEC layer revealed that α1β1 integrin plays a significant role in invasion of HS.939T cells, while α2β1 integrin appears to be more important for MV3 cells. In an animal model of hematogenous metastasis of the mouse B16F10 cell line, the inhibitory effect of viperistatin and VP12 was only partial. These data suggest that collagen receptors may be an interesting target for development of new anti-metastatic therapies.
Are mammotropic hormones mainly permissive for the development of breast cancer?

In a case–control study nested within the Greek EPIC cohort, serum levels of estrone, estradiol, androstenedione, dehydroepiandosterone sulfate, testosterone and IGF‐1 were measured for 29 breast cancer patients and 58 control women, matched for age and menopausal status. There was little difference in breast cancer risk when values of 4–6—as compared to values of 1–3—hormones were elevated, a finding arguing against a positive interaction among these hormones. Breast cancer risk, however, was significantly and substantially lower among women with levels of all hormones below the corresponding age‐ and menopausal‐status‐predicted means, compared to women with levels of at least 1 hormone above the predicted mean (odds ratio = 0.11 with 95% confidence interval 0.01–0.90; p = 0.04). Our results suggest that the studied mammotropic hormones may act as permissive factors for breast cancer occurrence, and that the levels of some of them above the mean suffice for sustaining growth of a developing tumor. A corollary is that studies of mammotropic hormones in relation to breast cancer risk may also need to focus on the lower end of the distributions of these growth‐enhancing hormones. © 2005 Wiley‐Liss, Inc.
Impact of crop rotation and tillage on some soil quality characteristics

IMPACT OF CROP ROTATION AND TILLAGE ON SOME SOIL QUALITY CHARACTERISTICS C.A. Campbell, B.G. McConkey, R.P. Zentner V.O. Biederbeck, D. Curtin and H. Wang Research Centre Agriculture & Agri-Food Canada Swift Current, Saskatchewan S9H 3X2 An 1 1-yr rotation-tillage experiment conducted on a coarse-textured, Brown Chernozemic soil at Cantaur, southwestern Saskatchewan, was used to demonstrate the beneficial effects of reducing cropping frequency and tillage on selected soil biochemical and physical attributes. Treatment differences were most noticeable in the O-7.5 cm depth, and especially for C and N mineralization and water stable aggregates. Total organic matter and microbial biomass-N effectively distinguished the effect of cropping frequency (continuous wheat vs fallow-wheat) on the attributes assessed, but did less well in distinguishing tillage effects [no-tillage vs conventional tillage (really minimum tillage)]. Levels of soil test N, measured in the fallow-wheat system each fall, supported evidence that by reducing the tillage we have increased the N-supplying power of the soil. This suggests that an economic benefit may eventually accrue to producers who adopt improved crop management practices.
What makes a family business strong enough to manage conflicts

Die Forschung zu Konflikten in Familienunternehmen bietet eine Vielfalt an Ergebnissen, dass die Uberschneidung des Familiensystems und des Unternehmenssystems grose Spannungen und Konflikte erzeugt. Dennoch mangelt es an eingehender und aufklarender Konfliktforschung in Familienunternehmen und an Forschung uber dynamische Prozesse, wie etwa familiarer Ressourcen, die diese Konflikte reduzieren konnten. Um diese Forschungslucke etwas zu fullen, widmet sich diese Dissertation den dynamischen Prozessen an der Schnittstelle vom Familien- und Unternehmenssystem, die aufgrund interpersoneller Interaktionen und Ressourcentransaktionen entspringen. Im Besonderen beinhaltet die empirische Forschungsarbeit (1) die Effekte von Konflikten auf das Familienunternehmen und die Rolle von Familienressourcen auf die Konflikt-Unternehmens-Beziehung; (2) den konfliktreduzierende Effekt von Familienressourcen, wie etwa Familienklima und Zufriedenheit von Work-Family Konflikt auf das Familienunternehmen. Basierend auf einer Literaturrecherche und einer empirisch-quantitativen Studie, die an osterreichischen Familienunternehmen durchgefuhrt wurde, veranschaulicht diese Dissertation, dass das Familiensystem eine wertvolle Ressource fur das Familienunternehmen darstellt. Die theoretische Untermauerung erfolgt anhand einer Systemtheorie, die systemimmanente dynamische Prozesse aufzeigt und das Zusammenspiel der konzeptuellen Modelle erklart. Zusammenfassend zeigt sich, dass Interaktionen zwischen Familienmitglieder Konflikte auslosen konnen, die Einfluss auf das Unternehmen einnehmen konnen, aber wie die Familienmitglieder mit diesen Konflikten umgehen und die Starke und Ressourcen, die sie entwickeln unterstutzt diese und das Familienunternehmen, auf lange Sicht erfolgreich und gesund zu bleiben.
Proposal for server management system by using embedded packet with VNIC

A computer has become possible to operate more services by improving the performance. Therefore, there is a growing tendency to aggregate a single computer. In consequence, a virtualization technology such as VM(Virtual Machine) is receiving a lot of attention. However, there are some problems with VM. For example, by running plural OSs on the same computer, the internal state of the computer will be more complex. Furthermore, it might be allocated too many resources such as CPU, Memory, and Hard Drive. In this paper, we propose the method which replaces VMs with VNIC(Virtual Interface Card)s in order to resolve these problems. In particular, we centralize the management of the services by using the embedded management packet and VNICs. As a result, the proposed system improves the problems of VMs.
CONTROL ENCRYPTION OF TECHNIQUE USING THE CLOUD COMPUTING SYD

Information storage and computing information issues can be overcome by mobile applications by using cloud computing. The new model can also make various data based on the cloud to chat, complete the location services and the operating system in real time well and at the same time. By combining cloud computing, security issues may arise, for example, data secrets and user authorization within cloud computing systems, which concern the first restrictions on the development of a mobile computer cloud. In order to provide a safe and powerful process, the hierarchical access control system is proposed using the encryption based on a fixed schedule and a structure under a modified format in this document. In this study, the independent control system is proposed through the encryption of the file according to the structural design of a three-story structural design. The ABE-based access control system uses several tags to distinguish the attributes the authorized user has to have. Within a certain cloud computing environment, large data for all types of mobile devices, such as mobile phones, calls, PDAs, etc., can be controlled and tested by the system, and the data can respond to an unauthorized third party and restricted to legal users as well.
New Scheme for Secured Routing in

Mobile ad hoc network (MANET) is an autonomous system of mobile nodes. Each node operates not only as an end system, but also as a router to forward packets. The nodes are free to move about and organize themselves into a network. These cause extra challenges on security. In this paper, evaluation of prominent on-demand routing protocol i.e. AODV,MAODV,RAODV has been done by varying the network size. An effort has been carried out to do the performance evaluation of these protocols using random way point model. The simulator used is NS 2.34. The performance of either protocol has been studied by using a self created network scenario with respect to pause time.
Writing between the Lines: Examining Unprompted Handwritten Student Comments on a Campus Climate Survey

ABSTRACT This study used data from an in-person paper-and-pencil climate survey administered to students in a random sample of classes at a four-year southeastern university. Respondents (N = 248) left unsolicited qualitative comments on the survey (N = 540). Grounded theory was used to determine if themes existed among them. Questions on school safety, rape myths, and resource knowledge prompted the most unsolicited comments (n = 111). Comments centered on clarification or opinions. Given the survey was adapted from a prior climate survey, unsolicited comments highlight areas of clarification and improvement for future iterations of climate surveys. Implications for campus safety are discussed.
The Remote Inverse Shape Design of Airfoils in Unsteady Flows

This paper uses a general framework to derive the discrete adjoint equations for the calculation of remote sensitivities in unsteady flows. These sensitivities are then succesfully used in the remote inverse shape design of turbulent unsteady flow around a single-element NACA0012 airfoil as well as the remote inverse design of laminar unsteady flow around the multi-element NLR 7301 configuration, with both examples at a high angle of attack. In order to reduce the considerable computational costs associated with these remote inverse designs, the use of larger time steps over unphysical adjusting periods as well as skipping time steps while recording the flow solution are investigated and are shown to work well in practice. Nomenclature J Objective function Q Flow variables Y Design variables R Flow residual R∗ Unsteady flow residual (∇QR ) Transpose of the unsteady flow Jacobian ∆t Time discretization step T Final time L Lagrangian ∂J ∂Y Gradient of objective function ψ Adjoint variables ∆T Coarse time discretization step N Total number of time steps N∗ Number of coarse time steps p Pressure p∗ Target pressure
Computational Modeling of the Regulatory Network Organizing the Wound Response in Arabidopsis thaliana

Plants are frequently wounded by mechanical impact or by insects, and their ability to adequately respond to wounding is essential for their survival and reproductive success. The wound response is mediated by a signal transduction and regulatory network. Molecular studies in Arabidopsis have identified the COI1 gene as a central component of this network. Current models of these networks qualitatively describe the wound response, but they are not directly assessed using quantitative gene expression data. We built a model comprising the key components of the Arabidopsis wound response using the transsys framework. For comparison, we constructed a null model that is devoid of any regulatory interactions, and various alternative models by rewiring the wound response model. All models were parametrized by computational optimization to generate synthetic gene expression profiles that approximate the empirical data set. We scored the fit of the synthetic to the empirical data with various distance measures, and used the median distance after optimization to directly and quantitatively assess the wound response model and its alternatives. Discrimination of candidate models depends substantially on the measure of gene expression profile distance. Using the null model to assess quality of the distance measures for discrimination, we identify correlation of log-ratio profiles as the most suitable distance. Our wound response model fits the empirical data significantly better than the alternative models. Gradual perturbation of the wound response model results in a corresponding gradual decline in fit. The optimization approach provides insights into biologically relevant features, such as robustness. It is a step toward enabling integrative studies of multiple cross-talking pathways, and thus may help to develop our understanding how the genome informs the mapping of environmental signals to phenotypic traits.
Endotoxin boosts the vascular endothelial growth factor (VEGF) in rabbits

Vascular endothelial growth factor (VEGF) is a cytokine that greatly increases vascular permeability and thereby promotes hypovolemia. The present study examines whether the plasma VEGF concentration is increased by a bolus injection of endotoxin 20 μg/kg in 30 rabbits, and whether the response is modified by vitamin A, which doubles the endotoxin clearance. The results show that endotoxin stimulates a gradual increase in the VEGF concentration to a peak 5 h later which is approximately 100 times higher than the baseline concentration. No statistically significant difference was found between the rabbits that received no further treatment (n = 10) and the ones that were given 1000 IE/kg of vitamin A intravenously 1 h before (n = 10) or after (n = 10) the endotoxin. The rise in VEGF correlated with the development of fever, and the VEGF concentrations were higher in animals with a severely affected physical status as judged by the breathing pattern and changes in posture or reactivity. In conclusion, release of VEGF is part of the cytokine response to endotoxin with a peak occurring 5 h after a bolus injection, and the rise is pronounced also in the presence of a high endotoxin clearance.