Miracle-dz/UniFAR-FTUs huggingface dataset:
A one linear actuator hopping robot: modeling and control

This paper addresses the modeling and control design of a one linear actuator hopping robot. The robot consists of a body and a leg, which are in contact with a sufficiently wide horizontal ground surface; both are fixed rigidly. Force actuation affects the angle of the body by a force couple that arises due to the mass of the body, as well as the length of the leg; hence both the angular velocity of the body and height of a jump can be controlled by only one actuator. Since the aim of this study is to achieve continuous hopping motion while keeping the system as simple as possible, an ON-OFF actuator is employed. Hence, we consider utilizing the thrust timing of the actuator—when robot is in the stance phase—to control the gait. For better stability of the hopping motion, optimization of mechanical parameters was made possible by evaluating the numerically obtained transition map, which contains a transition from one standard position to the next. The system is considered as a discrete system, in which one cycle of motion is regarded as one sampling interval. Finally, a control system was designed in which, by simulation, the continuous hopping gait was realized.
Recent Progress in Herpes Simplex Virus Immunobiology and Vaccine Research

SUMMARY Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) cause prevalent, chronic infections that have serious outcomes in some individuals. Neonatal herpes may occur when the infant traverses the cervix during maternal genital herpes. Genital herpes is a major risk factor for human immunodeficiency virus type 1 transmission. Considerable efforts have been made to design and test vaccines for HSV, focusing on genital infection with HSV-2. Several protein subunit vaccines based on HSV-2 envelope glycoproteins have reached advanced-phase clinical trials. These antigens were chosen because they are the targets of neutralizing-antibody responses and because they elicit cellular immunity. Encouraging results have been reported in studies of treatment of HSV-seronegative women with a vaccine consisting of truncated glycoprotein D of HSV-2 and a novel adjuvant. Because most sexual HSV transmission occurs during asymptomatic shedding, it is important to evaluate the impact of vaccination on HSV-2 infection, clinically apparent genital herpes, and HSV shedding among vaccine recipients who acquire infection. There are several other attractive formats, including subunit vaccines that target cellular immune responses, live attenuated virus strains, and mutant strains that undergo incomplete lytic replication. HSV vaccines have also been evaluated for the immunotherapy of established HSV infection.
Finite-Time Synchronous Control for Multiple Manipulators With Sensor Saturations and a Constant Reference

This paper is devoted to the finite-time synchronous control problem for multiple manipulators subject to sensor saturations. An effective framework through defining a class of coordinated saturation functions is introduced, under which the distributed protocols with continuous feedbacks are constructed. By applying the homogeneous theory for stability analysis, it is proven that all the multiple manipulators converge to the target position in finite time without disturbances. In the presence of disturbances, it is shown that the position errors can reach a neighborhood of the origin in finite time. Numerical simulations on four robot manipulators with two degrees of freedom are presented to demonstrate the efficiency of our proposed protocols.
A novel template‐based automatic rigging algorithm for articulated‐character animation

Rigging is a process for creating skeletons used to animate articulated characters. In conventional computer‐animation software, this process must be performed manually. Although several automatic rigging algorithms have been proposed, these methods still require user intervention. This paper proposes an automatic algorithm that generates an inverse kinematic skeleton for a character by locating an appropriate template skeleton on the extracted curve skeleton of the input 3D character model. After the curve skeleton is extracted, it is analyzed and classified into an appropriate category. The classification conditions are developed from the characteristics of each kind of real animal. We also develop an algorithm to extract the anatomical meaning of each skeleton segment. On the basis of the classification result, a suitable template skeleton is retrieved from the database. Each bone of the template skeleton can then be located on the appropriate skeleton segment of the input skeleton graph by using the extracted anatomical meanings. In contrast to previous methods, the algorithm does not require the input 3D character models to have certain poses or orientations. Moreover, all processes can be completed without user intervention. Copyright © 2012 John Wiley & Sons, Ltd.
A jigsaw puzzle based secret key exchange scheme

In cryptography, how to distribute a secret key in a secure way is an important issue. In this paper, based on cryptographic and data hiding techniques, we propose a new and high secure secret key exchange scheme. In this scheme, a sender will embed his secret key on an image to form a jigsaw puzzle image, and the jigsaw puzzle image will be posted on his/her Web site. Then the receiver can download the jigsaw puzzle image to extract the secret key. The scheme provides three security levels. The first is that the secret key is encrypted using a public cryptosystem before embedding. The second is that the existence of the secret key will be concealed such that no one will doubt that any secret information is included. The third is that the man in the middle attack problem can be solved.
Cost-Sensitive Feature Selection of Data with Errors

In data mining applications, feature selection is an essential process since it reduces a model's complexity. The cost of obtaining the feature values must be taken into consideration in many domains. In this paper, we study the cost-sensitive feature selection problem on numerical data with measurement errors, test costs and misclassification costs. The major contributions of this paper are four-fold. First, a new data model is built to address test costs and misclassification costs as well as error boundaries. Second, a covering-based rough set with measurement errors is constructed. Given a confidence interval, the neighborhood is an ellipse in a two-dimension space, or an ellipsoidal in a three-dimension space, etc. Third, a new cost-sensitive feature selection problem is defined on this covering-based rough set. Fourth, both backtracking and heuristic algorithms are proposed to deal with this new problem. The algorithms are tested on six UCI (University of California - Irvine) data sets. Experimental results show that (1) the pruning techniques of the backtracking algorithm help reducing the number of operations significantly, and (2) the heuristic algorithm usually obtains optimal results. This study is a step toward realistic applications of cost-sensitive learning.
Steady State Visually Evoked Potential Correlates of Auditory Hallucinations in Schizophrenia

This study attempted to localize regions of brain electrical activity associated with the onset of auditory hallucinations. Changes in Steady State Visually Evoked Potential (SSVEP) topography associated with the onset of spontaneous auditory hallucinations was studied in eight schizophrenic patients. The SSVEP elicited by a spatially uniform sinusoidally varying visual flicker was recorded using a 64-channel electrode helmet. A large and significant decrease in SSVEP latency in the right temporo/parietal region occurred in the second prior to the report of auditory hallucinations. A control task with matching motor movements produced no significant decrease in SSVEP latency in the same right temporo/parietal location. This finding suggests that activity of fine temporal resolution in the neural networks in the right temporo/parietal area may be implicated in the genesis of auditory hallucination, in conformity with certain neuropsychological theories.
MRI surveillance of cancer cell fate in a brain metastasis model after early radiotherapy

Incidence of brain metastasis attributed to breast cancer is increasing and prognosis is poor. It is thought that disseminated dormant cancer cells persist in metastatic organs and may evade treatments, thereby facilitating a mechanism for recurrence. Radiotherapy is used to treat brain metastases clinically, but assessment has been limited to macroscopic tumor volumes detectable by clinical imaging. Here, we use cellular MRI to understand the concurrent responses of metastases and nonproliferative or slowly cycling cancer cells to radiotherapy.
Frameshift Mutations in the Bax Gene Are Not Involved in Development of Ovarian Endometrioid Carcinoma

The purpose of this study was to determine whether mutations in the Bax gene play a role in the development of ovarian endometrioid carcinoma with a microsatellite instability phenotype. We analyzed a total of 60 tumor specimens, 49 ovarian endometrioid carcinomas and 11 concurrent endometrial endometrioid carcinomas from 49 patients. Fourteen ovarian endometrioid carcinomas and 6 endometrial endometrioid carcinomas showed a microsatellite instability-high phenotype. Tumor and normal-tissue specimens from eight patients with a microsatellite instability-high phenotype colorectal carcinoma were included in this study as controls. The presence or absence of a mutation in the poly (G) 8 tract of the Bax gene was determined by polymerase chain reaction followed by direct DNA sequence analysis. A 1-base pair deletion at the poly (G) 8 tract and no expression of Bax and Bcl-2 proteins were identified in one microsatellite instability-high endometrial endometrioid carcinoma. Immunohistochemical staining for Bax and Bcl-2 proteins was negative on the tumor specimen that had this 1-base pair deletion. No mutations were found in the synchronous microsatellite instability-high ovarian endometrioid carcinoma from the same patient. In contrast, four (50%) of the eight microsatellite instability-high sporadic colorectal carcinomas had a mutation in the poly (G) 8 tract. Although Bax plays an important role in carcinogenesis of the colorectum with microsatellite instability-high phenotype, Bax may not play a direct role in the genesis of ovarian endometrioid carcinoma, regardless of microsatellite instability status.
Health-protective behaviours and risk of fall-related hip fractures: a population-based case–control study

Background : fall-related hip fractures are one of the most common causes of disability and mortality in older age. The study aimed to quantify the relationship between lifestyle behaviours and the risk of fall-related hip fracture in community-dwelling older people. The purpose was to contribute evidence for the promotion of healthy ageing as a population-based intervention for falls injury prevention. Methods : a case–control study was conducted with 387 participants, with a case–control ratio of 1:2. Incident cases of fall-related hip fracture in people aged 65 and over were recruited from six hospital sites in Brisbane, Australia, in 2003–04. Community-based controls, matched by age, sex and postcode, were recruited via electoral roll sampling. A questionnaire designed to assess lifestyle risk factors, identified as determinants of healthy ageing, was administered at face-to-face interviews. Results : behavioural factors which had a significant independent protective effect on the risk of hip fracture included never smoking [adjusted odds ratio (AOR): 0.33 (0.12–0.88)], moderate alcohol consumption in mid- and older age [AOR: 0.49 (0.25–0.95)], not losing weight between mid- and older age [AOR: 0.36 (0.20–0.65)], playing sport in older age [AOR: 0.49 (0.29–0.83)] and practising a greater number of preventive medical care [AOR: 0.54 (0.32–0.94)] and self-health behaviours [AOR: 0.56 (0.33–0.94)]. Conclusion : with universal exposures, clear associations and modifiable behavioural factors, this study has contributed evidence to reduce the major public health burden of fall-related hip fractures using readily implemented population-based healthy ageing strategies. Abstract Background : the Parkinson’s Disease Questionnaire (PDQ-39) is the most widely used Parkinson’s specific measure of health status. It is increasingly used in
Polarization Bistability Induced by Orthogonal Optical Injection in 1550-nm Multimode VCSELs

We have analyzed experimentally the optical power polarization bistability induced in a long-wavelength multitransverse mode vertical-cavity surface-emitting laser (VCSEL) under orthogonal optical injection. Bistability with very wide hysteresis cycles is measured for both the fundamental and the high-order transverse mode of the device. The shape of the associated hysteresis cycle is different for each of the two transverse modes. The power of the parallel polarized high-order (fundamental) transverse mode remains constant (gradually decreases) as the injected power is increased. Both powers suddenly drop to low levels at large values of the injected power. The squared shape measured for the I/O characteristic of the high-order transverse mode is of particular interest for obtaining good quality all-optical inversion and all-optical regeneration for use in optical telecommunication networks.
THE DEVELOPMENT OF HAPPY WORKPLACE INDEX

This research aims to study and develop a Happy Workplace Index using mixed methods research. Quantitative and qualitative data were collected using various methods such as: (1) literature review, (2) happy workplace index synthesis, (3) content validation by experts, (4) pilot study, and (5) analysis and improvement. Selection of organizations for quantitative sampling was done by randomly selecting organizations subjected to external review in 2008. Selection of organizations for qualitative sampling was done by assignment of selection criteria of informants including the organization leader, staff in personnel administration, and human resources management divisions. There were 93 organizations selected for quantitative review and 8 organizations selected for qualitative review. The research tools consisted of a self-evaluation handbook (Happy Workplace Index: Questionnaire for self-assessment), questionnaires for asking the staff and guideline for interviews. Qualitative data were analysed using content analysis and quantitative data were analysed using frequency, percentages, and exploratory factor analysis (EFA). The result revealed that the developed Happy Workplace Index was comprised of 39 indices set with 5 dimensions. The first dimension was human resources management (6 sub-indices), the second dimension was environment and atmosphere in enhancing health (10 sub-indices), the third dimension was healthy organization creation process (8 sub-indices), the fourth dimension was physical and mental health (11 sub-indices), and the fifth dimension was results (4 sub-indices). Results of EFA created 4 crucial components which are: component 1—Working atmosphere (18 sub-indices) with factor loading between 0.39 0.86, component 2—Human resources management (9 sub-indices) with factor loading between 0.48 0.67, component 3—Physical and mental health (4 sub-indices) with factor loading between 0.50 0.81, and component 4—Growth or organizational products quality (4 sub-indices) with factor loading between 0.35 0.77, which adequately
The Herpesvirus Transactivator VP16 Mimics a Human Basic Domain Leucine Zipper Protein, Luman, in Its Interaction with HCF

ABSTRACT In human cells infected with herpes simplex virus (HSV), viral gene expression is initiated by the virion protein VP16. VP16 does not bind DNA directly but forms a multiprotein complex on the viral immediate-early gene promoters with two cellular proteins: the POU domain protein Oct-1 and host cell factor (HCF; also called C1, VCAF, and CFF). Despite its apparent role in stabilizing the VP16-induced transcription complex, the natural biological role of HCF is unclear. Only recently HCF has been implicated in control of the cell cycle. To determine the role of HCF in cells and answer why HSV has evolved an HCF-dependent mechanism for the initiation of the lytic cycle, we identified the first human ligand for HCF (R. Lu et al., Mol. Cell. Biol. 17:5117–5126, 1997). This protein, Luman, is a member of the CREB/ATF family of transcription factors that can activate transcription from promoters containing cyclic AMP response elements (CRE). Here we provide evidence that Luman and VP16 share two important structural features: an acidic activation domain and a common mechanism for binding HCF. We found that Luman, its homolog in Drosophila, dCREB-A (also known as BBF-2), and VP16 bind to HCF by a motif, (D/E)HXY(S/A), present in all three proteins. In addition, a mutation (P134S) in HCF that prevents VP16 binding also abolishes its binding to Luman and dCREB-A. We also show that while interaction with HCF is not required for the ability of Luman to activate transcription when tethered to the GAL4 promoter, it appears to be essential for Luman to activate transcription through CRE sites. These data suggest that the HCF-Luman interaction may represent a conserved mechanism for transcriptional regulation in metazoans, and HSV mimics this interaction with HCF to monitor the physiological state of the host cell.
Cyproterone acetate and two doses of oestrogen in female acne; a double‐blind comparison

Cyproterone acetate was used in combination with either 35 or 50 μg ethinyl oestradiol in a double‐blind comparison of their effects on acne in females. There were no significant differences between the two groups in the degree of improvement in acne as assessed objectively by the investigators, or subjectively by the patients using a visual analogue scale. Oestrogen related side‐effects were significantly lower in the 35 μg group during the course of the 9‐month stud.
Dynamic capabilities of the Chinese Football Clubs

This dissertation is based on the ideas of dynamic capabilities in enterprise management science, it mainly discusses under dynamic circumstances, the effects of dynamic capabilities on Chinese Football Clubs' abilities to enhance their own strength and to maintain their competitive advantages. It establishes a research framework of retaining a dominant relationship between the clubs and their resource integration capability, tradition evolvement capability, and function transformation capability. This article utilizes network resources, interviews, internal club documents, discussions with senior football insiders, external documents and many other information sources to establish a fundamental research database; on the basis of the research database, it adopts multidimensional regression calculation method, cause and effect planning to analyze data, through case analysis examines under dynamic circumstances, ShanDong LuNeng football club's resource integration capability, tradition evolvement capability, and function transformation capability, thus, validates research propositions raised in this dissertation and in the process, reaches a conclusion: under dynamic circumstances, football clubs' dynamic capabilities has a positive effect on the continuous maintenance of competitive advantages during the self development phase of these domestic club
Structure determination of aligned samples of membrane proteins by NMR spectroscopy

The paper briefly reviews the process of determining the structures of membrane proteins by NMR spectroscopy of aligned samples, describes the integration of recent developments in the interpretation of spectra of aligned proteins and illustrates the application of these methods to the trans‐membrane helical domain of a protein. The emerging methods of interpreting the spectral parameters from aligned samples of isotopically labeled proteins provide opportunities for simultaneously assigning the spectra and determining the structures of the proteins, and also for comparing the results from solid‐state NMR experiments on completely aligned samples with those of solution NMR experiments on weakly aligned samples. Copyright © 2004 John Wiley & Sons, Ltd.
Visuospatial Short-Term Memory Explains Deficits in Tower Task Planning in High-Functioning Children with Autism Spectrum Disorder

Previous findings on planning abilities in individuals with high-functioning autism spectrum disorder (HFA) are inconsistent. Exploring possible reasons for these mixed findings, the current study investigated the involvement of memory in planning performance in 15 children with HFA and 17 typically developing controls. In addition to planning abilities (measured with the Tower of London), short-term memory and delayed recall for verbal as well as visuospatial material were assessed. Findings suggest that particularly reduced efficiency in visuospatial short-term memory is associated with Tower task planning deficits in children with HFA.
Chronic Myeloid Leukemia: Practical Issues in Diagnosis, Treatment and Follow-Up

Chronic myeloid leukemia (CML) is sometimes mentioned as the disease of “firsts”. 1) It is the first disease where the term “leukemia” was used. 2) It is the first neoplastic disorder which was found to be associated with a recurrent chromosomal abnormality. 3) It is the first disease where targeted therapy against a fusion protein was used. Entrance of BCR-ABL tyrosine kinase inhibitors, first imatinib and then dasatinib and nilotinib, into clinical practice within the last decade has fundamentally changed both treatment and follow-up of CML. In this review, practical points about CML have been summarized, with a special emphasis to treatment and follow-up.
A Comparison of Approaches for Person Re-identification

Advanced surveillance applications often require the ability to re-identify an individual. In the typical context of a sensor network, this means to recognize a subject acquired at one location among a feasible set of candidates acquired at another locations and/or over time. Usually this does not necessarily imply to know the identity, and actually it might remain unknown. This task is especially challenging in applications targeted at crowded environments. Face and gait are contactless biometrics which are particularly suited to be used for re-identification, but even âsoftâ biometrics have also been considered to this aim. This paper presents a comparison of approaches to re-identification, with some characteristic examples in literature, while a complete overview of the main researches is out of our scope. The goal is to provide an objective estimate of both the state-of-the-art and the potential of such techniques to further improve them and to extend the applicability of re-identification systems.
Identidade da psicologia: Revisão sistemática de uma década de literatura

A necessidade de compreender o core basico da intervencao psicologica tem ganho relevância nas mais recentes decadas. Este panorama surgiu a partir das numerosas mudancas que ocorreram na formacao dos psicologos, nas perspetivas profissionais, e tambem, dada a expansao do mercado de trabalho. Tais consideracoes devem fazer-nos refletir sobre a identidade profissional dos psicologos no presente e, consequentemente, sobre a identidade da Psicologia como area cientifica. Assim, o presente poster apresenta uma revisao sistematica da literatura das principais consideracoes obtidas. Todas as fases envolvidas no desenvolvimento desta revisao sistematica da literatura sao sistematizadas e os seus principais resultados sao apresentados.