Miracle-dz/UniFAR-FTUs huggingface dataset:
Stability of Outcomes Following Residential Drug Treatment for Patients With Co-occurring Disorders

Objective: Few studies have examined the stability of both substance use and mental health outcomes following residential drug abuse treatment for individuals with co-occurring disorders. This study examines outcomes at 6 and 12 months for individuals with co-occurring disorders, in relationship to services received over the follow-up period. Methods: Participants with co-occurring disorders (N = 310) were sampled from 11 residential drug abuse treatment programs and completed in-depth assessments within 30 days of intake and at 6- and 12-month follow-ups. A path model was developed testing the relationships among treatment participation and services received, psychological status, and substance use outcomes across the two follow-up points. Results: Retention for at least 90 days in residential drug treatment was associated with less inpatient mental health treatment and more mental health services received at 6 months; outpatient mental health treatment was associated with reduced substance use at 6 months. Substance use at 6 months was associated with more psychological distress at both 6 and 12 months and more inpatient mental health treatment at 12 months. Conclusions: Findings suggest that receipt of mental health services following residential drug abuse treatment for patients with co-occurring disorders is critical to improving their longer-term outcomes.
Hindi translation and validation of Cambridge-Hopkins Diagnostic Questionnaire for RLS (CHRLSq)

Background: Restless legs syndrome also known as Willis-Ekbom′s Disease (RLS/WED) is a common illness. Cambridge-Hopkins diagnostic questionnaire for RLS (CHRLSq) is a good diagnostic tool and can be used in the epidemiological studies. However, its Hindi version is not available. Thus, this study was conducted to translate and validate it in the Hindi speaking population. Materials and Methods: After obtaining the permission from the author of the CHRLSq, it was translated into Hindi language by two independent translators. After a series of forward and back translations, the finalized Hindi version was administered to two groups by one of the authors, who were blinded to the clinical diagnosis. First group consisted of RLS/WED patients, where diagnosis was made upon face to face interview and the other group - the control group included subjects with somatic symptoms disorders or exertional myalgia or chronic insomnia. Each group had 30 subjects. Diagnosis made on CHRLSq was compared with the clinical diagnosis. Statistical Analysis: Analysis was done using Statistical Package for Social Sciences (SPSS) v 21.0. Descriptive statistics was calculated. Proportions were compared using chi-square test; whereas, categorical variables were compared using independent sample t-test. Sensitivity, specificity, and positive predictive value of the translated version of questionnaire were calculated. Results: Average age was comparable between the cases and control group (RLS/WED = 39.1 ± 10.1 years vs 36.2 ± 11.4 years in controls; P = 0.29). Women outnumbered men in the RLS/WED group (87% in RLS/WED group vs 57% among controls; χ2 = 6.64; P = 0.01). Both the sensitivity and specificity of the translated version was 83.3%. It had the positive predictive value of 86.6%. Conclusion: Hindi version of CHRLSq has positive predictive value of 87% and it can be used to diagnose RLS in Hindi speaking population.
Cauda Equina Syndrome: Factors Affecting Long-term Functional and Sphincteric Outcome

Study Design. Retrospective cohort study with prospective clinical follow-up. Objective. To determine the factors that influence outcome after surgery for cauda equina syndrome (CES). Summary of Background Data. CES is a rare but serious consequence of lumbar disc prolapse and can have devastating long-lasting neurologic consequences. The timing of surgical decompression remains controversial. Methods. Fifty-six patients with evidence of a sphincteric disturbance who underwent urgent surgery were identified and invited to follow-up. The outcome measures comprised history and examination and several validated self-assessment questionnaires. Results. Forty-two patients (78%) attended with a mean follow-up of 60 months (range, 25–114 months). Mean age at onset was 41 years (range, 24–67 years) with 23 males and 19 females. Twenty-six patients were operated on within 48 hours of onset of sphincteric symptoms; 5 of these were within 24 hours. Acute onset of sphincteric symptoms and the time to operation did not influence the outcomes. Leg weakness at onset persisted in a significant number of patients at follow-up (P < 0.005). Urinary disturbance at presentation did not affect the outcomes. At follow-up, significantly more females had urinary incontinence (P < 0.005). Bowel dysfunction at presentation was associated with sexual problems at follow-up (P < 0.005). The 13 patients who failed their post operative trial without catheter had worse outcomes. The SF-36 scores at follow-up were reduced compared with age-matched controls in the population. The mean ODI was 29, Low Back Outcome Score 42, and VAS 4.5. The time elapsed from operation to follow-up was not found to influence the outcomes. Conclusions. In our series, the symptom duration before operation and the speed of onset do not affect the outcome more than 2 years after surgery. Based on the SF-36, ODI, and Low Back Outcome Scores, patients who have had CES do not return to a normal status.
Human UDP-Glucuronosyltransferase 1A5: Identification, Expression, and Activity

The human UDP-glucuronosyltransferase (UGT) subfamily 1A includes nine genes. The expression of all the UGT1A isoforms, apart from UGT1A5, has been reported previously. We have now detected a low basal level of UGT1A5 expression in cultured human hepatocytes, and treatment with rifampicin or 3-methylcholanthrene increased the level of UGT1A5 mRNA. Low-level UGT1A5 expression was also found in HepG2 and Caco-2 cells as well as human liver. Furthermore, UGT1A5 expression has been detected in various segments of the intestine from human donors, revealing high interindividual variability in its level and distribution along the intestine. Full-length UGT1A5 cDNA was isolated from Caco-2 cells that had been transfected with the pregnane X receptor and treated with rifampicin. Recombinant UGT1A5, expressed in baculovirus-infected insect cells, exhibited very low rates of 4-methylumbelliferone and scopoletin glucuronidation, whereas 1-hydroxypyrene was a much better substrate for it. UGT1A5 did not glucuronidate 4-aminobiphenyl, a good substrate for the highly homologous enzymes UGT1A4 and UGT1A3. However, replacing the first 110 amino acids of UGT1A5, a region that may be involved in substrate binding, with the counterpart segment from UGT1A4 did not increase the 4-aminobiphenyl glucuronidation activity. Collectively, this work demonstrates for the first time that the human UGT1A5 is expressed in several tissues, is inducible, and is catalytically active.
Self-Supervised Learning of Pose Embeddings from Spatiotemporal Relations in Videos

Human pose analysis is presently dominated by deep convolutional networks trained with extensive manual annotations of joint locations and beyond. To avoid the need for expensive labeling, we exploit spatiotemporal relations in training videos for self-supervised learning of pose embeddings. The key idea is to combine temporal ordering and spatial placement estimation as auxiliary tasks for learning pose similarities in a Siamese convolutional network. Since the self-supervised sampling of both tasks from natural videos can result in ambiguous and incorrect training labels, our method employs a curriculum learning idea that starts training with the most reliable data samples and gradually increases the difficulty. To further refine the training process we mine repetitive poses in individual videos which provide reliable labels while removing inconsistencies. Our pose embeddings capture visual characteristics of human pose that can boost existing supervised representations in human pose estimation and retrieval. We report quantitative and qualitative results on these tasks in Olympic Sports, Leeds Pose Sports and MPII Human Pose datasets.
Regulation of cap‐dependent translation initiation in the early stage porcine parthenotes

The binding of mRNAs to ribosomes is mediated by the protein complex eIF4F in conjunction with eIF4B (eukaryotic initiation factor 4F and 4B). EIF4F is a three subunit complex consisting of eIF4A (RNA helicase), eIF4E (mRNA cap binding protein), and eIF4G (bridging protein). The crucial role is played by eIF4E, which directly binds the 5′‐cap structure of the mRNA and facilitates the recruitment to the mRNA of other translation factors and the 40S ribosomal subunit. EIF4E binding to mRNA and to other initiation factors is regulated on several levels, including its phosphorylation on Ser‐209, and association with its regulatory protein 4E‐binding protein (4E‐BP1). In this study we document that both the translation initiation factor eIF4E and its regulator 4E‐BP1 become dephosphorylated in the early stage porcine zygotes already 8 hr post‐activation. Similarly, the activities of ERK1/2 MAP and Mnk1 kinases, which are both involved in eIF4E phosphorylation, gradually decrease during this period with the timing similar to that of eIF4E dephosphorylation. The formation of an active eIF4F complex is also diminished after 9–15 hr post‐activation, although substantial amounts of this complex have been detected also 24 hr post‐activation (2‐cell stage). The overall protein synthesis in the parthenotes decreases gradually from 12 hr post‐activation reaching a minimum after 48 hr (4‐cell stage). Although the translation is gradually decreasing during early preimplantation development, the eIF4F complex, which is temporarily formed, might be a premise for the translation of a small subset of mRNAs at this period of development. Mol. Reprod. Dev. 75: 1716–1725, 2008. © 2008 Wiley‐Liss, Inc.
Detection of Proteobacteria from the rumen by PCR using methanotroph‐specific primers

Aims: To detect Proteobacteria, including methanotrophs, from the rumen fluid and the bacteria inhabiting the rumen epithelium. Methods and Results:Proteobacteria inhabiting the rumen were detected by PCR using methanotroph‐specific primers. The detected Proteobacteria were divided into clusters A, B, and C in addition to one clone, which was distinct from the clusters and closely related to Nitrosomonas sp. The clusters A, B, and C were close to Succinivibrio dextrinosolvens, Enterobacter cloacae, and Actinobacillus minor, respectively. The clones obtained from the rumen fluid each belonged to cluster A or B. The clones obtained from the rumen epithelium belonged to cluster B or C or to Nitrosomonas sp. Conclusions: It has been assumed that the rumen fluid and the rumen epithelium host different populations of Proteobacteria. Moreover, detection of Nitrosomonas from the rumen epithelium would indicate the possibility that the bacterium oxidizes ammonia and methane on the rumen surface. Significance and Impact of the Study: These findings suggest that the rumen fluid and the epithelium support different microbial populations, which would play specific roles in rumen function. Future study should focus on the relationship between these communities and physiological functions in the rumen.
Enhancing the Australian Regional Racing Experience for Tourists: A Betting Aid for Novice Punters

Racing (thoroughbred, harness, and greyhound) brings many visitors and economic and social benefits to regional areas in Australia. Many casual gamblers, however, have little knowledge of racing and of the fundamental rules that underpin its various forms (which, while reasonably consistent across both location and type, do differ in some respects). In this article, we describe a decision support system designed to assist and educate novice punters. A motive underpinning this research was a desire to produce a tool that might assist visitors wishing to experience the Australian provincial racing circuit to get the most out of their involvement.
Palmprint Matching using Pairwise Relative Angle Histogram

In this paper, we propose a novel approach to retrieve line-patterns from large databases in a rotation and translation invariant manner, at the same time, tackle broken line problem. Line segments are extracted from an image as primitives. Each local structure is represented by a set of pair-wise angle relationships, which are simple, invariant to translation and rotation, robust to end-point erosion, segment error, and sufficient for discrimination. Experiment showed encouraging results which also implicate that line segments could provide sufficient information for palmprint recognition.
Effects of spatial configuration and number of fixations on Kanizsa triangle detection.

PURPOSE Illusory figures, created by the visual system between visualizing real objects, are probably caused by processes designed to segregate objects from background. Support ratio--that is, the ratio between the physically specified and total triangle side length--has been suggested to be the main spatial determinant for suprathreshold perception of a Kanizsa-type illusion. To test this scale invariance hypothesis at threshold, illusory figure perception was studied by determining the effects of inducer size and distance at various exposure durations and fixation strategies on the frequency of seeing (FoS) an illusory Kanizsa triangle. METHODS The effect of various support ratios was studied in the first experiment by varying the intercenter distance between constant-size inducers viewed at various distances. In the second experiment, the effects of various exposure durations and fixation strategies were investigated; and the third experiment repeated the second one, with backward masking to control the processing time. In the fourth experiment, the magnification of the stimulus configuration was varied, with a support ratio that had yielded 100% FoS in the first experiment, to study the range of scale invariance in illusory figure perception. RESULTS The support ratio was the main determinant for the perception of an illusory figure at various inducer sizes, exposure durations, and masking conditions when fixation was steady; FoS always increased from 0% to 100% with the support ratio of 0.30 to 0.37. However, free viewing, with and without masking, resulted in 100% illusory figure perception at all support ratios tested. Furthermore, when fixation was steady and support ratio and exposure duration were held constant, stimulus magnification reduced FoS from 100% to 0% at the smallest and largest stimulus sizes. CONCLUSIONS The support ratio seems to be the main spatial determinant for illusory figure perception. However, scale invariance in Kanizsa triangle perception broke down in the smallest and largest configurations, probably because of the limitations of visual acuity and spatial integration, respectively. Integration of information from several fixations enhances FoS at small support ratios, emphasizing the importance of the binding process between separate fixations for illusory figure perception.
Who would prefer to mention you on the urban microblog mention network?: Evidence from Sina microblog data across 94 cities in China

It is widely accepted that breaking the geographical boundaries is one of the core features of the Internet, thus a question is that whether the population-level interaction network on social media has been out of the geographical constrains? Based on Sina microblog data of 94 cities in China in 2015, this study constructed the urban mentioned network of talking about each other, and explored the interaction characteristics of city- level mention network. Results showed that the density of a city mentioned by others is highly correlated with its economic development, while the density of a city initiatively mentioning others is negatively correlated with the economy. Further analysis indicated that the distance between cities is significantly negatively correlated with the density of mention, which is consistent with the Tobler's First Law of Geography. In addition, the density of mention is also significantly positively correlated with the GDP of the mentioned cities, but negatively related to the GDP of the mentioning city, which is both similar to and different from the Newton's Law and Gravity Model in international trading. We propose that the phenomenon of a city being mentioned is associated with the popularity and influence of the city, and the urban mention network follows the law of Analogous Gravity Model, which may be attributed to the psychological motivation such as social comparison.
Obesity in Turkish children and adolescents: prevalence and non-nutritional correlates in an urban sample.

OBJECTIVES The aim of the present study was to identify the prevalence and non-nutritional correlates of childhood obesity in primary school children and adolescents living in a representative sample of an urban area in western Anatolia. METHODS The study was designed as a cross-sectional, population-based study. A representative sample of primary school children in Aydin was randomly selected according to age, gender and socio-economic status. Body mass index (BMI) was calculated after weight and height measurement. Centres for Disease Control 2000 growth charts for children and adolescents were used to identify BMI percentiles. Weight and height percentiles were obtained from charts of growth curves for Turkish children. RESULTS The age range of children was 6-16 years. A total of 924 children and 424 adolescents were screened for obesity. Overweight and obesity prevalence in primary school children living in Aydin was 12.2% and 3.7%, respectively. High socio-economic status was found to be associated with childhood obesity. There was no association between obesity and gender, adolescence, educational status of parents and occupation of father. CONCLUSION In the present study, we focused on some of the non-nutritional correlates of obesity in a representative population of an urban area in a developing country. Obesity prevalence rate in Turkish children living in Aydin was higher in children from a higher socio-economic group in contrast to reports from many developed countries.
Where have all the children gone? Women's reports of more childlessness at older ages than when they were younger in a large-scale continuous household survey in Britain

Levels of childlessness reported by the same cohorts of women and surveyed by the British General Household Survey increase with age by over 50 per cent between their early 40s and their late 50s for women born in the early 1940s. Yet the reported mean fertility of parous women remains constant with increasing age. Similar results hold within sub-groups such as different educational and marital status groups. Possible reasons for these findings include declining comparability of the base population over time due to differential migration, mortality, or institutionalization, changes in survey design and content, and differential non-response by childless and parous women. The evidence shows that these are not adequate explanations. The most likely reason is deliberate under-reporting of childbearing among older cohorts of women. The findings have implications for the interpretation of retrospective data in surveys and for the availability of informal care for older people.
Functional and immunocytochemical characterization of D‐serine transporters in cortical neuron and astrocyte cultures

D‐serine is an endogenous coagonist of N‐methyl‐D‐aspartate (NMDA) receptors that plays an important role in synaptic function, neuronal development, and excitotoxicity. Mechanisms of D‐serine transport are important in regulation of extracellular D‐serine concentration and therefore of these critical processes. D‐serine can be transported with low affinity through the Na+‐dependent amino acid transporter termed ASCT2, whereas high‐affinity D‐serine uptake has been reported through the Na+‐independent transporter termed asc‐1. We investigated immunoreactivity for ASCT2 and asc‐1 and D‐serine transport kinetics in cultured cortical neurons and astrocytes to gain insight into how D‐serine transporters regulate CNS D‐serine levels. Both neurons and astrocytes exhibited low‐affinity Na+‐dependent D‐serine uptake (KT > 1 mM) with broad substrate selectivity that was consistent with uptake through ASCT2. Both neurons and astrocytes also stained positively for ASCT2 in immunocytochemistry studies. Neurons but not astrocytes stained positively for the high‐affinity D‐serine transporter asc‐1, but no evidence of functional asc‐1 could be detected in neurons with conditions that produced such activity in cortical synaptosomes. These data support ASCT2 function in both neuron and astrocyte cultures and identify a discrepancy between observed asc‐1 immunoreactivity and lack of functional asc‐1 activity in neuron cultures. Together these findings further our knowledge of the processes that govern D‐serine regulation. © 2009 Wiley‐Liss, Inc.
Synapses of extrinsic and intrinsic origin made by callosal projection neurons in mouse visual cortex

Neurons in areas 17/18a and 17/18b of mouse cerebral cortex were labeled by the retrograde transport of horseradish peroxidase (HRP) transported from severed callosal axons in the contralateral hemisphere. Terminals of the local axon collaterals of labeled neurons (intrinsic terminals) were identified in the border regions of area 17 with areas 18a and 18b, and their distribution and synaptic connectivity were determined. Also examined were the synaptic connections of extrinsic callosal axon terminals labeled by lesion‐induced degeneration consequent to the severing of callosal fibers. A postlesion survival time of 3 days was chosen because by this time the extrinsic terminals were all degenerating, whereas the intrinsic terminals were labeled by horseradish peroxidase.
Branching morphology of decapitated arborescent monocotyledons with secondary growth.

UNLABELLED • PREMISE OF THE STUDY Dragon trees (Dracaenaceae) are arborescent monocotyledons with anomalous secondary growth and are able to branch, exhibiting a treelike habit. Studies of the morphology and anatomy of ramifications allow for a better understanding of the complex course and arrangement of the vascular bundles in the stem-branch attachment region for Dracaena and other arborescent monocots with anomalous secondary growth. • METHODS Morphological and anatomical analyses of ramifications induced in decapitated specimens of D. marginata and D. reflexa included serial sectioning, maceration, staining, and bleaching techniques as well as high and low resolution optical microscopy and three-dimensional (3D)-visualization techniques. • KEY RESULTS The use of innovative 3D reconstruction and high-resolution imaging revealed the extent of connections between branch and stem on various hierarchical levels in Dracaena A stem-clasping attachment of the side shoot was observed, which in more detail shows a strong regional dependence of course and connectivity of individual vascular bundles to the main stem. Consequently, the attachment of branch tissue is strongly limited to the outer periphery of the main stem. • CONCLUSIONS Our results indicate that the observed course of vascular bundles with fiber caps cannot only be a result of physiological need for water and nutrient supply but are interpreted in terms of mechanical constraints acting on the branching region. In addition, the used 3D cine technique and coupled 3D reconstruction provide a valuable tool for botanists working in the field of anatomy.