Miracle-dz/UniFAR-FTUs huggingface dataset:
Chromosomal 3 and 8 status within hepatic metastasis of uveal melanoma.

CONTEXT Several studies have evaluated clinical, histopathologic, cytogenetic, and molecular prognostic variables in uveal melanoma. However, it is not known whether the primary tumor cells maintain these aggressive attributes at the metastatic sites. OBJECTIVE To determine the status of chromosomes 3 and 8q and c-myc amplification using fluorescence in situ hybridization on hepatic metastatic lesions of primary uveal melanoma. DESIGN Ten patients with uveal melanoma with needle core biopsy-confirmed hepatic metastasis. Representative paraffin blocks were selected based on review of hematoxylin-eosin-stained sections. Fluorescence in situ hybridization was performed for detection of monosomy 3 and amplification at the 8q24 MYC locus using standard methods. The tricolor chromosome enumeration probe 8 (CEP8)/IGH/MYC and the Urovysion probe consisting of CEP3, CEP7, CEP17, and 9P21 probes were used. A total of 200 interphase cells were scored. RESULTS Hepatic metastasis was confirmed in each case by needle core biopsy. Fluorescence in situ hybridization analysis revealed chromosome 3 monosomy in 5 of the 8 cases that could be satisfactorily evaluated. Aneusomy of chromosome 8 was observed in 2 cases. MYC amplification was observed in 5 samples. In a single case where the primary tumor was treated by enucleation, the chromosomal monosomy 3 and aneusomy of chromosome 8 were present both in the primary tumor and its hepatic metastatic lesion. CONCLUSIONS The presence of cytogenetic changes within the metastatic lesions confirms that chromosome 3 monosomy and aneusomy of chromosome 8 are not just markers of metastatic potential of the primary tumor but are also present within the hepatic metastatic lesions.
A note on input-to-state stability and averaging of systems with inputs

Two different definitions of an average for time-varying systems with inputs and a small parameter that were recently introduced in the literature are considered: "strong" and "weak" averages. It is shown that if the strong average is input-to-state stable (ISS), then the solutions of the actual system satisfy an integral bound in a semiglobal practical sense. The integral bound that we prove can be viewed as a generalization of the notion of finite-gain L/sub 2/ stability, that was recently introduced in the literature. A similar result is proved for weak averages but the class of inputs for which the integral bound holds is smaller (Lipschitz inputs) than in the case of strong averages (measurable inputs).
Antecedents of Information Privacy Assimilation in Indian IT Organizations: An Empirical Investigation

Information privacy at the organizational level is receiving increased attention due to the huge amount of personal information being stored, transmitted across national boundaries, and ownership being shared between organizations due to change in business dynamics. This study develops a framework for understanding the mechanisms of information privacy assimilation in Information Technology (IT) organizations. There is a great need for investigating the interplay between external forces and internal influencers that impact the privacy assimilation practices within an organization. To fill this gap, we empirically examined the interplay between the external forces and internal influencers following the institutional theory. Specifically, we have examined the nature and relative significance of influencing forces, and the mediating role of senior management participation. Also, the moderating effects of process capability and cultural aspects have been investigated. This study treats information privacy as a distinct dimension separate from information security. Our findings show that mediating role of senior management participation for coercive and normative forces. Mimetic forces appears to have direct impact on assimilation. Also, positive moderating effect of process capability and negative moderating effect of cultural aspects is observed for coercive forces. These findings would enable senior managers identify and respond to institutional pressures by focusing on appropriate factors within the organization.
Extension of an Analytic Secondary Source Selection Criterion for Wave Field Synthesis

Wave field synthesis (WFS) is a spatial sound reproduction technique that facilitates a high number of loudspeakers (secondary sources) to create a virtual auditory scene for a large listening area. It requires a sensible selection of the loudspeakers that are active for the reproduction of a particular virtual source. For virtual point sources and plane waves suitable intuitively derived selection criteria are used in practical implementations. However, for more complex virtual source models and loudspeaker array contours the selection is not straightforward. In a previous publication the author proposed a secondary source selection criterion on basis of the sound intensity vector. This contribution will extend this criterion to data-based rendering and focused sources, and will discuss truncation effects.
Researching the EPON technology in the intelligent communication network

The paper introduces the EPON network structure and protocol, and its key technologies, including uplink and downlink, ONU automatic discovery, DBA and other technology, gives an application example of EPON. Using the technology to construct the network, have some advantages: cost is relatively low, rate is high, expanded easily, the efficiency of match data business is high, so it become one of the main technology of access of fiber.
High-Performance Concurrency Control Mechanisms for Main-Memory Databases

A database system optimized for in-memory storage can support much higher transaction rates than current systems. However, standard concurrency control methods used today do not scale to the high transaction rates achievable by such systems. In this paper we introduce two efficient concurrency control methods specifically designed for main-memory databases. Both use multiversioning to isolate read-only transactions from updates but differ in how atomicity is ensured: one is optimistic and one is pessimistic. To avoid expensive context switching, transactions never block during normal processing but they may have to wait before commit to ensure correct serialization ordering. We also implemented a main-memory optimized version of single-version locking. Experimental results show that while single-version locking works well when transactions are short and contention is low performance degrades under more demanding conditions. The multiversion schemes have higher overhead but are much less sensitive to hotspots and the presence of long-running transactions.
Moderated Disanxiousuncertlibrium: Specifying the Moderating and Neuroaffective Determinants of Violation-Compensation Effects

abstraction , andthe subsequent iteration of the MMM incorporatedthis compensatory effort into our descriptive taxon-omy (Proulx & Heine, 2010). In later empirical work,we demonstrated that unrelated meaning violations,such as absurd art and mortality threats, increased astate need for simple structure (Proulx, Heine, & Vohs,2010)—as had previously been demonstrated follow-ing violations of personal control (Whitson & Galin-sky, 2008). We took these additional ﬁndings as furtherevidencethatdifferentviolationsarebestunderstoodinterms of expected associations, more generally, ratherthan as operating primarily in terms of a speciﬁed con-tent, whether it involves human mortality, surreal im-ages, or personal control (the latter account suggestedby Galinsky et al., this issue). Moreover, evidence that these violations bottleneckat a common arousal mechanism can be derived froma number of sources, including the “misattribution ofthe arousal” literature discussed in the target article:Compensation efforts following behavioral dissonance(Zanna & Cooper, 1974), visual anomalies (Proulx &Heine, 2008), and control violations (Kay, Moscov-itch, & Laurin, 2010) are all extinguished if peopleare able to attribute their arousal to a placebo pill, orif they are told that a placebo pill will render themimmune to arousal (Greenberg et al., 2003). More re-cently, Randles, Heine, and Santos (in press) demon-strated that compensatory afﬁrmation following mor-tality reminders and surreal images was extinguishedif participants received an actual pain pill. In general, itappears that all of these violations bottleneck at someform of aversive arousal, with violation–compensationperspectives throughout the ﬁeld of psychology posit-ing some mode of aversive arousal following the viola-tionagiven belieforgoal.What,then,isthissensation,and is it the same mode of arousal following any givenviolation? Is disequilibrium (Piaget, 1937/1954) thesame as behavioral dissonance (Festinger, 1957)? Isit the same as ideological dissonance (Jost, Pelham,Sheldon, & Sullivan, 2003)? What about its similarityto the “potential terror” that arises from a reminder ofour own mortality (Pyszczynski et al., 1999)? Until we are able to specify this arousal be-yond a kind of “brain phlogiston,” our literature will
Maternal use of fluconazole and risk of congenital malformations: a Danish population-based cohort study.

OBJECTIVES Fluconazole is widely used for the treatment of candidiasis. Although the drug is also prescribed to pregnant women, data on the safety of use of fluconazole during pregnancy are limited. We examined the association between the maternal use of fluconazole during pregnancy and the risk of congenital malformations. PATIENTS AND METHODS In this population-based cohort study in Northern Denmark, we included 1079 women who had a live birth or a stillbirth after the 20th week of gestation and who redeemed at least one prescription for fluconazole during the first trimester. The reference cohort comprised 170 453 pregnant women who redeemed no fluconazole prescription during pregnancy. The women were identified through the Danish Medical Birth Registry. Data on drug use, birth outcome and covariates were extracted from population-based healthcare databases. We used logistic regression to estimate the prevalence odds ratio (POR) for congenital malformations after fluconazole exposure, while adjusting for maternal smoking, parity, maternal age and concurrent prescriptions for antiepileptics or antidiabetics. RESULTS Among 1079 women who filled a fluconazole prescription during the first trimester, 797 (74%) received a total of 150 mg of fluconazole, 235 (22%) received 300 mg of fluconazole, 24 (2%) received 350 mg of fluconazole and 23 (2%) received 600 mg of fluconazole. These women gave birth to 44 (4.1%) children with congenital malformations. The 170 453 women without fluconazole prescriptions gave birth to 6152 (3.6%) children with congenital malformations. For congenital malformations overall, the adjusted POR associated with the first-trimester fluconazole use was 1.0 (95% confidence interval: 0.8-1.4). CONCLUSIONS We found no overall increased risk of congenital malformations after exposure to short-course treatment with fluconazole in early pregnancy.
Occupational allergic contact dermatitis from N,N‐bis(3‐aminopropyl)dodecylamine and dimethyldidecylammonium chloride in 2 hospital staff

Keywords: patch tests; disinfectants; antiseptics; Gigasept; antibacterials; preservatives; biocides; occupational; hospital personnel; allergic contact dermatitis; dimethyldidecylammoniumchloride; N,N-bis(3-aminoprophyl)dodecylamine
UvA-DARE ( Digital Academic Repository ) Large Scale Co-Regularized Ranking

As unlabeled data is usually easy to collect, semisupervised learning algorithms that can be trained on large amounts of unlabeled and labeled data are becoming increasingly popular for ranking and preference learning problems [6, 23, 8, 21]. However, the computational complexity of the vast majority of these (pairwise) ranking and preference learning methods is super-linear, as optimizing an objective function over all possible pairs of data points is computationally expensive. This paper builds upon [16] and proposes a novel large scale co-regularized algorithm that can take unlabeled data into account. This algorithm is suitable for learning to rank when large amounts of labeled and unlabeled data are available for training. Most importantly, the complexity of our algorithm does not depend on the size of the dataset. We evaluate the proposed algorithm using several publicly available datasets from the information retrieval (IR) domain, and show that it improves performance over supervised methods. Finally, we discuss possible implications of our algorithm for learning with implicit feedback in an online setting.
Soft and stable routing protocol for cognitive radio VANETs considering cognitive users mobility

In this paper, a Soft and Stable Routing (SSR) protocol for cognitive radio vehicular ad hoc networks, (CRVANET), is proposed which is robust to cognitive user mobility and primary user activity. Considering primary users activity causes soft spectrum mobility while deploying cognitive users mobility allows stable routing. The protocol allows nodes to collect spectrum information during a spectrum management interval followed by a transmission period. Cognitive users discover routes by joint channel and next hop selection (synchronization) in the transmission intervals. A restricted forwarding strategy is adopted to avoid performance degradation specially due to routing overhead. By considering PU activity SSR selects safe routes against primary users and by considering mobility parameters of cognitive users, the protocol selects stable routes. SSR protocol performance is investigated through simulation in different scenarios and is compared with the modified version of DAODV protocol. The results indicate that SSR can achieve significant reduction in control overhead as well as improving route stability.
Design and implementation of a low-voltage fast-switching mixed-signal-controlled frequency synthesizer

A new frequency synthesizer based on combining the analog phase-locked loop (PLL) and the all digital PLL (ADPLL) is presented. The frequency synthesizer achieves high frequency resolution, broad frequency range, high switching speed, and low supply voltage. The oscillator is controlled by both the digital control word and the control voltage of the analog PLL. It is an array oscillator implemented by symmetric load differential inverting buffers which provide better rejection to supply noise and fabrication variance. Fractional-N divider and delay interpolation technique are employed to enhance the divider resolution without inducing jitter. A binary search algorithm is used to find the proper digital frequency control word, which can be saved for later use and greatly speed up the frequency switching process. Fabricated using a 0.6-/spl mu/m SPTM CMOS process, the synthesizer achieves a frequency range of 54-154 MHz with a frequency error less than 1 ppm and a frequency switching time less than 10 /spl mu/s. The chip consumes very little power and draws 47 mW from a 2-V supply voltage.
Simple Methods for Peak Detection in Time Series Microarray Data.

In this work we describe a set of analytical and statistical methods enabling the identification of genes which spike expression within narrow time-windows of Plasmodium falciparum Intraerythrocytic Developmental Cycle. Moreover we assign a functional group to each gene by using SVM algorithm and discuss about possible biological role.
Extracellular calcium changes the morphology of induced pinocytosis in Amoeba proteus

Summary. The morphology of pinocytosing Amoeba proteus induces by two monovalent cations: Na + and K + were examined at different calcium concentration. It was demonstrated that pinocytotic response of amoeba (number, size and shape of pinocytotic pseudopodia) was related to the amount of Ca 2+ accumulated on the cell surface.
Online HIV awareness and technology affordance benefits for black female collegians - maybe not: the case of stigma

OBJECTIVE We investigate the technology affordances associated with and anticipated from an online human immunodeficiency virus (HIV) prevention awareness platform, myHealthImpactNetwork, intended to reach black female college students. This population is at increased risk for HIV transmission, but is not often studied. In addition, this population regularly uses digital tools, including Web sites and social media platforms, to engage in health information seeking. MATERIALS AND METHODS We conducted 11 focus groups with 60 black female college students attending 2 universities in the United States. Focus groups were recorded, transcribed, and analyzed using content analyses. RESULTS Contrary to our proposition, the participants' information needs did not align with the anticipated benefits associated with the technology affordances of the prevention awareness platform. Concerns about personal online social capital, reputation management, and stigma limited participants' willingness to engage with the HIV prevention content on the website. DISCUSSION Although the participants use digital tools as a primary means of becoming informed about health, concerns that friends, family, and others in their social networks would assume that they were HIV infected limited their willingness to engage with myHealthImpactNetwork. Print media and conversations with health care professionals were preferred channels for obtaining HIV prevention information. CONCLUSIONS Perceptions of stigma associated with HIV negatively impact health information seeking and sharing in the online social networks in which black college students engage. However, by understanding the unanticipated consequences, researchers can effectively design for cultures and subcultures infected and affected by health disparities.
Engineering cis-telomerase RNAs that add telomeric repeats to themselves

Telomerase is a ribonucleoprotein complex consisting of a protein reverse transcriptase (TERT) and an RNA subunit (TR). Telomerase normally adds telomeric DNA repeats to chromosome ends. Here, we engineer human and Tetrahymena cis-telomerase RNAs, each having a DNA primer covalently linked to its 3′ end. We find that cis-telomerase synthesizes DNA with increased repeat addition processivity (RAP) but does not completely rescue the RAP defect of the L14A mutant of Tetrahymena TERT. This supports the conclusion that L14 has a function beyond binding the DNA primer and preventing dissociation during multiple rounds of repeat addition. By comparing cis-telomerases with various linker lengths, we find that a 5 nt linker gives near-optimal activity, indicating that the distance between the 3′ end of the telomerase RNA pseudoknot region and the 5′ end of the DNA primer is ∼33 Å. Even a 2 nt linker (∼14 Å) gives some activity, indicating a high degree of conformational flexibility in this ribonucleoprotein complex. More generally, the cis system will allow structure-function relationships of each RNA molecule to be read directly through the reaction that it performs on itself.
HITS is principal components analysis

In this work, we show that Kleinberg's hubs and authorities model (HITS) is simply principal components analysis (PCA; maybe the most widely used multivariate statistical analysis method), albeit without centering, applied to the adjacency matrix of the graph of Web pages. We further show that a variant of HITS, SALSA, is closely related to correspondence analysis, another standard multivariate statistical analysis method. In addition, to provide a clear statistical interpretation for HITS, this result suggests to rely on existing work already published in the multivariate statistical analysis literature (extensions of PCA or correspondence analysis) in order to analyse or design new Web pages scoring procedures.
Improving I / O Performance through an In – Kernel Disk Simulator

This paper presents two mechanisms that can significantly improve the I/O performance of both hard and solid-state drives for read operations: KDSim and REDCAP. KDSim is an in-kernel disk simulator that provides a framework for simultaneously simulating the performance obtained by different I/O system mechanisms and algorithms, and for dynamically turning them on and off, or selecting between different options or policies, to improve the overall system performance. REDCAP is a RAM-based disk cache that effectively enlarges the built-in cache present in disk drives. By using KDSim, this cache is dynamically activated/deactivated according to the throughput achieved. Results show that, by using KDSim and REDCAP together, a system can improve its I/O performance up to 88% for workloads with some spatial locality on both hard and solid-state drives, while achieves the same performance as a “regular system” for workloads with random or sequential access patterns.
Surgical treatment of appendiceal mucocele.

HYPOTHESIS Clinical presentation of appendiceal mucocele is related to malignancy and can influence surgical approach. DESIGN Retrospective study. SETTING Tertiary referral center. PATIENTS All cases of primary appendiceal mucoceles (simple mucocele, cystadenoma, cystadenocarcinoma) diagnosed between 1976 and 2000 were reviewed. There were 135 patients, 74 of whom were female. Mean age at diagnosis was 59 years. Mean follow-up was more than 6 years. INTERVENTIONS A total of 129 patients underwent surgery, consisting of appendectomy (22 patients), right hemicolectomy (25 patients), or more extensive procedures (82 patients). MAIN OUTCOME MEASURES Clinical, diagnostic, and surgical variables were statistically compared with postoperative morbidity and mortality and the presence of malignancy. P<. 05 was considered significant. RESULTS The presence of symptoms was associated with malignancy (58% vs 15%, P<.001), particularly abdominal pain (56% vs 29%, P =.005) and weight loss (77% vs 31%, P =.002). Abdominal mass was also associated with malignancy (86% vs 25%, P<.001). Moreover, pseudomyxoma peritonei and mucocele extravasation were associated with malignancy (95% vs 13%, P<.001, and 83% vs 15%, P<.001, respectively). The lesion size was not associated with malignancy; however, cystadenomas were significantly larger than simple mucoceles (8.1 cm vs 4.1 cm, P<.001), and no cystadenoma was less than 2 cm in largest diameter. CONCLUSIONS A number of clinical, diagnostic, and intraoperative findings are associated with malignant mucoceles. All mucoceles greater than 2 cm should be excised to remove premalignant lesions.