Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors for Information Technology Acceptance Willingness and Adoption in Logistics Industry from Supply Chain Perspectives

It is generally believed that adoption of new technologies, especially information technologies, not only improves the operating efficiencies, but also generates competitive advantages in logistics industry. In order to create or retain supply chain competitive advantages, identification of the factors for the willingness and adoption of new technologies is critical. The technology adoption process proposed in this study is based on technology acceptance model (TAM) with introduction of supply chain relationship factors. Since earlier studies indicated that environmental status may play a moderate role in the adoption process, moderation effect between the willingness and adoption of technologies is investigated. Major findings of the study include: (1) Perceived easiness of use and perceived usefulness directly affect technology acceptance willingness, but indirectly affect technology adoption through the willingness; (2) Supply chain relationship does not exert impacts on the willingness, but directly affects the adoption behavior. Based on the research findings, suggestions are provided for logistics and technology development industries when performing technological innovation.
Maturation and localization of the TolB protein required for colicin import

The tolB gene has been shown previously to encode two proteins of 47.5 kDa (TolB) and 43 kDa (TolB*). To explain the presence of these two forms, two hypotheses have been proposed: TolB might be posttranslationally processed to TolB*, or an internal in-frame translation initiation resulting in TolB* may occur (S. K. Levengood and R. E. Webster, J. Bacteriol. 171:6600-6609, 1989). To address this question, TolB was tagged by inserting in its C-terminal region an epitope recognized by monoclonal antibody 1C11 without altering the function of TolB. It was then demonstrated that the functional protein corresponded to TolB*, the mature periplasmic protein, and that TolB was its precursor form, which was observed only when the protein was overexpressed. These two forms were purified by immunoprecipitation, and their N-terminal sequences were determined. An antibody directed against TolB was raised, which confirmed the results obtained with the tagged TolB.
The cost of checking proportional hazards

Confidence intervals (CIs) and the reported predictive ability of statistical models may be misleading if one ignores uncertainty in the model selection procedure. When analyzing time‐to‐event data using Cox regression, one typically checks the proportional hazards (PH) assumption and subsequently alters the model to address any violations. Such an examination and correction constitute a model selection procedure, and, if not accounted for, could result in misleading CI. With the bootstrap, I study the impact of checking the PH assumption using (1) data to predict AIDS‐free survival among HIV‐infected patients initiating antiretroviral therapy and (2) simulated data. In the HIV study, due to non‐PH, a Cox model was stratified on age quintiles. Interestingly, bootstrap CIs that ignored the PH check (always stratified on age quintiles) were wider than those which accounted for the PH check (on each bootstrap replication PH was tested and corrected through stratification only if violated). Simulations demonstrated that such a phenomenon is not an anomaly, although on average CIs widen when accounting for the PH check. In most simulation scenarios, coverage probabilities adjusting and not adjusting for the PH check were similar. However, when data were generated under a minor PH violation, the 95 per cent bootstrap CI ignoring the PH check had a coverage of 0.77 as opposed to 0.95 for CI accounting for the PH check. The impact of checking the PH assumption is greatest when the p‐value of the test for PH is close to the test's chosen Type I error probability. Copyright © 2007 John Wiley & Sons, Ltd.
Splicing regulation in spinal muscular atrophy by an RNA structure formed by long‐distance interactions

Humans carry two copies of the survival motor neuron gene: SMN1 and SMN2. Loss of SMN1 coupled with skipping of SMN2 exon 7 causes spinal muscular atrophy (SMA), a leading genetic disease associated with infant mortality. Our discovery of intronic splicing silencer N1 (ISS‐N1) is a promising target, currently in a phase III clinical trial, for an antisense oligonucleotide–mediated splicing correction in SMA. We have recently shown that the first residue of ISS‐N1 is locked in a unique RNA structure that we term ISTL1 (internal stem through long‐distance interaction–1). Complementary strands of ISTL1 are separated from each other by 279 nucleotides. Using site‐specific mutations and chemical structure probing, we confirmed the formation and functional significance of ISTL1. Located in the middle of intron 7, the 3′ strand of ISTL1 falls within an inhibitory region that we term ISS‐N2. We demonstrate that an antisense oligonucleotide–mediated sequestration of ISS‐N2 fully corrects SMN2 exon 7 splicing and restores high levels of SMN in SMA patient cells. These results underscore the therapeutic potential of the regulatory information present in a secondary and high‐order RNA structure of a human intron.
Cellular Senescence Controlled by p53 is a Barrier to Environmental

Cancer development in humans and animals may be caused by environmental factors. It has been estimated that approximately 80% of human tumors are generated by exposure to environmental carcinogens. The carcinogens may initiate or induce progression of tumors in several ways. Cellular senescence is a natural barrier used by cells to respond to stress. The molecular analysis of immortal clones shows alterations, either structural or epigenetic, in the genes involved in cellular senescence. It is thought that these alterations are caused directly by mutating or methylating the genes involved in cellular senescence. Therefore, understanding cellular senescence and how it can be modified by environmental carcinogens may be essential to control the increase in cancer prevalence. In the present work, we explored the role of cellular senescence barrier in the carcinogenic potential of some known carcinogens. We found that most carcinogens tested induce a primary senescent response in diploid mouse embryonic fibroblasts (MEFs) and the clones arising with proliferative capacity contain mutated p53 protein. This primary response of senescence induction is abolished in the presence of the p53 inhibitor, pifithrin-a. Under these conditions, the tumorigenic potential of carcinogens is greatly increased. Upon elimination of pifithrin-a from the media, cellular senescence is restored. Therefore, the first cellular response to a carcinogen is a cell cycle arrest program that may result in a permanent arrest with features of cellular senescence. If there is a concomitant alteration of genes involved in cellular senescence, which promotes cellular immortalization, a further carcinogenic insult may increase the chances of tumorigenesis and a malignant clone may develop.
Simulation du soudage par friction et malaxage à l'aide de méthodes sans maillage

Le procede de soudage par friction et malaxage est un procede recent qui a ete developpe au sein de l'institut de soudure britannique "The Welding Institute" au debut des annees 90. Ce procede, utilise generalement en aeronautique, est sans apport de matiere et permet de souder principalement des alliages d'aluminium difficilement soudables par les procedes classiques de soudage. Il consiste a malaxer le materiau de base a l'aide d'un outil constitue d'un pion et d'un epaulement frottant sur les faces superieures des toles a souder. La modelisation de ce procede est tres complexe puisque ce dernier implique des couplages entre des phenomenes mecaniques, thermiques et metallurgiques. Le malaxage dans le procede de soudage FSW est difficile a simuler a l'aide de la methode des elements finis (en lagrangien) puisque la zone proche de l'outil de soudage est le siege de grandes deformations. Donc le remaillage est necessaire. Cependant, le remaillage est cher et tres difficile pour les problemes tridimensionnels. Par ailleurs, apres un remaillage, il est necessaire d'interpoler les champs (vitesses, contraintes,.) correspondant a la solution courante, ce qui peut introduire des erreurs supplementaires dans le calcul (on parle de diffusion numerique). Nous proposons dans ce travail des modeles bases sur la methode sans maillage dite "Smoothed Particle Hydrodynamics SPH" et la methode des moindres carres mobiles (Moving Least Square MLS) pour la simulation de ce procede. Ces modeles sont formules dans le cadre lagrangien et utilisent la forme forte des equations aux derivees partielles. Le premier modele base sur SPH considere la zone de soudure comme un fluide non newtonien faiblement compressible et dont la viscosite depend de la temperature. Ce modele est propose pour la simulation numerique du comportement thermomecanique d'un materiau soude par le procede FSW. Dans le deuxieme modele, un algorithme iteratif implicite de premier ordre a ete propose, pour simuler le malaxage de la matiere dans le cas d'un materiau viscoplastique, en utilisant la methode MLS et la technique de collocation. Le troisieme modele est un algorithme implicite d'ordre eleve basee sur le couplage de la methode MLS et la Methode Asymptotique Numerique MAN. Cet algorithme permet de reduire le temps de calcul par rapport a l'algorithme iteratif implicite de premier ordre. La validation de ces trois modeles proposes a ete faite par le code industriel Fluent
The Value of Combined Peritumoral and Subdermal Injection Techniques for Lymphoscintigraphy in Detection of Sentinel Lymph Node in Breast Cancer

Purpose: The aim of this study was to evaluate the success rate of combined peritumoral and subdermal injection techniques based on our previous experience on different injection techniques for lymphoscintigraphy. Patients and Methods: Fifty-nine women with early breast cancer (mean tumor size, 20.5 mm) were prospectively studied. On the morning of the operation, each patient had 2 injections, one peritumoral (PT) medial to the lesion and one subdermal (SD) into the skin over the tumor quadrant. Each injection consisted of 20 MBq (540 mCi) Tc-99m rhenium sulfide colloid. Early dynamic and delayed static images were obtained up to 4 hours after injections. An intraoperative gamma probe was used to explore the axillary sentinel lymph nodes (SLN). All surgical specimens were evaluated histopathologically. Results: Forty patients had breast-preserving surgery and 19 had modified radical mastectomy. Thirty-eight patients had axillary dissection. All but 4 patients showed axillary lymphatic drainage. Twelve of 59 patients (20%) showed extraaxillary drainage with lymphoscintigraphy. Combined injection technique yielded a 93.2% success rate in detecting axillary SLN. In 2 of 4 patients with no drainage on lymphoscintigraphy, intraoperative gamma probe revealed SLN during the surgery. Twenty patients (33%) had positive axillary lymph nodes. In 14 of them, the SLN was the only positive node. A false-negative rate was found 1.6% (one of 59 patients). Conclusion: This results suggest that a combination of both PT and SD techniques increases the success rate of visualization SLN and enhances the visualization of extraaxillary nodes for further treatment planning.
A national service evaluation of the impact of alcohol on admissions to Scottish intensive care units *

Alcohol‐related disease adversely affects the outcome of critically ill patients. The burden of this in Scotland is higher than elsewhere in the United Kingdom. In a prospective observational study of all patients admitted to the 24 intensive care units in Scotland we assessed the proportion of admissions in which alcohol‐related disease was implicated. Of 771 admissions, 642 (83.3%) were unplanned and 196 (25.4%) were related to alcohol. There was a significantly higher proportion of men in the alcohol‐related admissions group (140 (71.4%) vs 291 (50.6%), p = 0.009). This group was also significantly younger with median (IQR [range]) ages of 51 (38–63 [16–89]) vs 63 (48–73 [16–92]) years (p < 0.001). The alcohol‐related group had a significantly longer period of ventilation with a median (IQR [range]) of 2 (1–6 [0–176]) vs 1 (0–4 [0–136]) days (p < 0.005). Admissions from an area of deprivation were more likely to be related to alcohol. Alcohol‐related admissions have a significant impact on Scottish intensive care services, with an extrapolated cost of £8.9 million per year.
The effect of women directors on innovation activity and performance of corporate firms: Evidence from China

This paper elaborates whether women bringing their diversity, cross-cultural awareness and transformational leadership skills to corporate boards offer strategic advantages for firms. In the analysis the effect of women in the board room on innovation activity and corporate firm performance as well as the joint consequences of female directors and innovation activity on the firms success are examined. The latter may be particularly important in the context of gender diversity as more gender-diverse boards allow for higher levels of creativity and hence innovation. In order to account for endogeneity issues, different model specifications are employed (two-way fixed effects models and linear dynamic panel data models). Unconditional quantile regressions are used in order to go beyond the mean. The analysis is conducted using Chinese firm-level data from 2006-2015. The results suggest positive ef- fects of gender diversity in corporate boards and patenting activities on firm performance. Women directors are found to have statistically significant effects on both input-(positive) and output-oriented (negative) innovation activity.
PENGARUH CAPITAL ADEQUACY RATIO (CAR), NON PERFORMING LOAN (NPL), LOAN TO DEPOSIT RATIO (LDR), RETURN ON ASSET (ROA) DAN NET INTEREST MARGIN (NIM) TERHADAP PERTUMBUHAN LABA (Studi Empiris Pada Perusahaan Perbankan Indonesia Periode 2011-2015)

This research is to know and analyze the influence of Capital Adequacy Ratio (CAR), Non Performing Loan (NPL), Loan To Deposit Ratio (LDR), Return On Asset (ROA), And Net Interest Margin (NIM) On Growth Income. the design of the study is causal with the unit of analysis is the company's adage of the samples taken by purposive sampling technique on the population of banking companies listed on the BEI in 2011-2015. The analysis technique used is multiple linear regression with the help of SPSS 22.0 and hypothesis test using t test. The results showed that partially CAR and LDR affect the profit growth. while NPL, ROA, and NIM have no effect on profit growth. CAR, LDR, NPL, ROA and NIM variables are simultaneously influential to profit growth. Keyword : Capital Adequacy Ratio (CAR), Non Performing Loan (NPL), Loan To Deposit Ratio (LDR), Return On Asset (ROA), And Net Interest Margin (NIM) On Growth Income
Colour agnosia impairs the recognition of natural but not of non-natural scenes

Scene recognition can be enhanced by appropriate colour information, yet the level of visual processing at which colour exerts its effects is still unclear. It has been suggested that colour supports low-level sensory processing, while others have claimed that colour information aids semantic categorization and recognition of objects and scenes. We investigated the effect of colour on scene recognition in a case of colour agnosia, M.A.H. In a scene identification task, participants had to name images of natural or non-natural scenes in six different formats. Irrespective of scene format, M.A.H. was much slower on the natural than on the non-natural scenes. As expected, neither M.A.H. nor control participants showed any difference in performance for the non-natural scenes. However, for the natural scenes, appropriate colour facilitated scene recognition in control participants (i.e., shorter reaction times), whereas M.A.H. 's performance did not differ across formats. Our data thus support the hypothesis that the effect of colour occurs at the level of learned associations.
The effects of travelling reasons on social media resources and tourist expectations

This research aims to examine the relationship of user generated content (UGC) sources in social media which is provided by strong-tie sources and weak-tie sources on tourist expectations on core resources and factor supporting of the destinations, and also analyze the moderate effect of the reasons of travelling on the relationship of UGC sources and tourist expectations. 375 samples were collected. The results demonstrate that travelling reasons is an important factor to consider about the origin of tourist expectations. The UGC that was provided by weak-tie source has influence on tourist expectations when they travel with business reason.
Bringing DNA-guided medicine to the Hispanic population.

DNA-guided medicine poses great advantages for the highly heterogeneous Hispanic population. Similar to others in Latin America, the Puerto Rican population originated as a result of admixture between Amerindians, whose ancestors had migrated from the Amazon Basin and arrived in Puerto Rico 2200 years before present, and Spaniard and West-African individuals. The island of Puerto Rico thus is endowed with a distinctive population in terms of its gene flow. There are growing numbers of Puerto Ricans in the USA. Currently, Puerto Ricans represent 1.2% of the USA population and 9.6% of the Hispanic population in the USA. Admixture studies in Puerto Ricans, either in the island or the continental USA, have been scarce. The history of migration and admixture can be reconstructed and interpreted using genetic markers. Our results demonstrated that population analysis can be performed with functionally important genes instead of conventional ancestry informational markers to increase the relevance of population genetic studies for clinical epidemiology and personalized medicine. In this commentary, we examine the various implications of these findings and suggest an interpretation of the data utilizing a collage technique.
CSI Impaired Precoding Optimization for Energy-Efficient MIMO Communications Under Total Power Constraint

This letter considers robust precoding for improving the energy efficiency (EE) in a multiple-input multiple-output (MIMO) channel when only imperfect or partial channel state information (CSI) is available at the transmitter. From the perspective of worst case robustness, we aim to maximize the worst case EE subject to additive or multiplicative bounded CSI uncertainties and under total power constraint. Theoretically, we prove that the robust energy-efficient precoding optimization leads to a channel-diagonalizing structure. Accordingly, the complicated matrix-valued problem is equivalently transformed into a simpler scalar optimization problem, which can be solved efficiently with a water-filling interpretation for the optimal power allocation. The obtained worst case EE was finally verified and evaluated via numerical simulations.
Entrepreneurship and Economic Performance in Africa: A Sectoral Analysis with Focus on the Role of Finance, Institutions and Globalization

The main aim of the paper was to investigate the role of entrepreneurship on economic performance but with focus on sector-wide growth in 12 selected African countries during the period 2006-2016. Overall, the results suggest that while the quantitative impact of entrepreneurship on economic growth is positively significant, there is a differential effect on the sectors. The service sector in particular is associated positively with entrepreneurship whereas there is no evidence in the data that the growth in the manufacturing and agriculture sectors is influenced by entrepreneurship activities. A further analysis that includes interactions in the model supports the conditionality hypothesis that globalization as well as the quality of institutions and financial development matter in the entrepreneurship-growth nexus. In addition, while internet access and government consumption appear beneficial for the manufacturing and service sectors, the role of personal remittances is observed important for the agriculture sector contribution to GDP whereas trade in services matters for each sector but most significantly in the latter sector. In light of the findings policy recommendations are suggested.
Metabolism of glycolic acid in lactating and nonlactating goats and in a calf.

Abstract Several characteristics of glycolic acid metabolism were measured in lactating and nonlactating goats by a primer dose plus 3-hour constant infusion technique. The average turnover rate of glycolic acid was 1.7g per hour, and no lactation effect was observed. The turnover time averaged 9.5 minutes with a half-life of 6.6 minutes. Administered 14 C-glycolic acid was rapidly oxidized to 14 CO 2 with 44% appearing in CO 2 by 5 hours. About 1% of total expired CO 2 was derived from glycolic acid. Some glycolic acid was incorporated into milk components. After 5 hours, . 41% of the infused 14 C-glycolic acid was incorporated into casein, . 08% into fat, and about 2% into lactose. During an identical period, 14 C-glucose was incorporated into casein, fat and lactose at . 4%, . 5% and 32% of the administered dose. Glycolic acid was detected also in rabbit, swine, and horse blood. Turnover rates of glycolic acid in a calf were similar to those in the goats, and after phlorizin treatment about the same amount of radioactivity was in urine glucose as was in milk lactose from the lactating goats. The rate of oxidation to CO 2 was somewhat slower. Only a trace of radioactive glycolic acid was excreted in the urine.
Nanomolar Inhibition of Type II Dehydroquinase Based on the Enolate Reaction Mechanism

We describe the rational design of a novel, highly potent inhibitor of type II dehydroquinase, the dicarboxylate 6. The incorporation of a carboxylate at the 3‐position mimics the putative enolate intermediate in the reaction mechanism, and allows a potential electrostatic binding interaction with the arginine on the active site flap. This results in a 1000‐fold increase in potency, making the dicarboxylate 6 the most potent inhibitor of type II dehydroquinase reported to date, with a high ligand efficiency of −0.68 kcal mol−1 per nonhydrogen atom. The systematic dissection of 6 in compounds 7–12, all of which show a drop in potency, confirm the synergistic importance of the two carboxylates, the C3 and C4 hydroxyl groups, and the anhydroquinate ring structure for the potency of 6.