Miracle-dz/UniFAR-FTUs huggingface dataset:
Specific relationships between core beliefs and personality disorder symptoms in a non‐clinical sample

The current study examined the relationship of clinically relevant core beliefs measured by the Young Schema Questionnaire-Short Form (YSQ-SF) to personality disorder (PD) symptoms in a large non-clinical sample (N = 804). Results indicated that the 15 YSQ-SF scales added sizeable explained variance (4% to 13%) to self-reported symptoms of 12 PDs, above variance explained by gender and symptoms of other PDs. In addition, several specific core beliefs related uniquely to individual PDs after controlling for the other core beliefs. Given that core beliefs related to personality disorder symptoms in a non-clinical sample of people at the typical onset age of PDs, it is possible that such beliefs might be important to understanding the development of PDs. Copyright © 2007 John Wiley & Sons, Ltd.
Polyribosomal changes during inhibition of rabbit hemoglobin synthesis by an isoleucine antagonist.

Optimal hemoglobin synthesis in intact rabbit reticulocytes requires the presence of several amino acids in the incubation medium.1 These may be termed "essential" amino acids. The rapid hydrolysis of particulate proteins during maturation of reticulocytes2 provides an intracellular source of many other amino acids which need not be added to the medium. The omission of the complete amino acid component required for optimal hemoglobin synthesis does not affect the ribosome-polyribosome profile of these cells if an adequate source of iron for heme synthesis is available.3 However, the selective omission of tryptophan from an otherwise complete medium brings about polyribosome disaggregation.4 This disaggregation is due to the location of tryptophan only near the amino-terminal ends of rabbit hemoglobin, at position 14 in the a-chain, and in positions 15 and 37 of the fl-chain.6' 6 Since growth of the peptide chains proceeds from the amino-terminal end, 8 during a deficiency of tryptophan the rate of translation of messenger RNA is retarded near this end at the sites of tryptophan residues. If the other essential amino acids are present, there will be a normal rate of translation beyond these sites, and the inhibition results in polyribosome disaggregation because of a failure in the system to maintain the steadystate number of ribosomes on messenger RNA.4 Isoleucine occupies positions 10, 17, and 55 from the amino-terminal end of the a-chain of rabbit hemoglobin5' 9 and position 112 of the fl-chain.10 Since the aandfl-chains contain 141 and 146 amino acids, respectively, the isoleucine codon may be considered as located near the proximal end of messenger RNA of the achain and near the distal end of the messenger RNA of the fl-chain. Under normal conditions, messenger RNA coding for peptide chains of hemoglobin can hold up to six ribosomes in a saturated polyribosome configuration.1 Hence, under conditions of an isoleucine deficiency, the a-chain polyribosomes should become disaggregated to dimers, whereas the f-chain polyribosomes would consist principally as tetramers and pentamers. Omission of isoleucine from a mixture of amino acids has no effect on hemoglobin synthesis or on the ribosome-polyribosome profile of rabbit reticulocytes. A sufficient supply of this amino acid is furnished to the amino acid pool of the cell by protein turnover.2 It is possible, however, to limit the availability of isoleucine for protein synthesis with the use of the isoleucine antagonist O-methylthreonine. This isostere of isoleucine is activated by isoleucyl-RNA synthetase of mammalian cells, but is not transferred to tRNA.12 In this communication we describe the effect of O-methylthreonine on the synthesis of rabbit hemoglobin by intact reticulocytes. Materials and Methods. -Preparation of reticulocytes and incubation conditions have been described.13 The amino acids reported as essential by Borsook et al. were present
Branch vanguard: Decomposing branch functionality into prediction and resolution instructions

While control speculation is highly effective for generating good schedules in out-of-order processors, it is less effective for in-order processors because compilers have trouble scheduling in the presence of unbiased branches, even when those branches are highly predictable. In this paper, we demonstrate a novel architectural branch decomposition that separates the prediction and deconvergence point of a branch from its resolution, which enables the compiler to profitably schedule across predictable, but unbiased branches. We show that the hardware support for this branch architecture is a trivial extension of existing systems and describe a simple code transformation for exploiting this architectural support. As architectural changes are required, this technique is most compelling for a dynamic binary translation-based system like Project Denver. We evaluate the performance improvements enabled by this transformation for several in-order configurations across the SPEC 2006 benchmark suites. We show that our technique produces a Geomean speedup of 11% for SPEC 2006 Integer, with speedups as large as 35%. As floating point benchmarks contain fewer unbiased, but predictable branches, our Geomean speedup on SPEC 2006 FP is 7%, with a maximum speedup of 26%.
Intranasal Vaccination with Mannosylated Chitosan Formulated DNA Vaccine Enables Robust IgA and Cellular Response Induction in the Lungs of Mice and Improves Protection against Pulmonary Mycobacterial Challenge

Induction of specific humoral and cellular immunity in the lung airways is proposed to be critical for vaccine protection against Mycobacterium tuberculosis (M. tb). To facilitate airway delivery and antigen targeting to the antigen presenting cells in the alveoli, we employed mannosylated chitosan (MCS) to formulate a multi-T-epitope DNA vaccine, pPES, as an intranasal TB vaccine. MCS-DNA nanoparticles appeared spherical with the average particle sizes as 400 nm. HSP65-specific bronchoalveolar lavage fluid SIgA level was significantly elevated by 4 doses of MCS-pPES intranasal immunization as compared to chitosan (CS)-DNA and BCG vaccine. I.n. immunization with MCS-DNA induced a modest peptide-specific Th1(IFN-γ, TNF-α, and IL-2) response in the spleen, while a potent poly-functional CD4+ T response that largely produced TNF-α and IFN-γ, as well as IL-2 in the lung, qualitatively better than that induced by CS-DNA and BCG vaccination. Such response by i.n. immunization with MCS-DNA provided improved protection in the lung against airway Mycobacterial bovis BCG challenge over i.n. CS-DNA and DNA, that is comparable to protection achieved by s.c. BCG vaccination. This enhanced protection was correlated with much greater accessibility of DNA particles to the alveolar macrophages in the lung mediated by man-chitosan. Thus, man-chitosan TB vaccine represents a promising vaccine platform capable of eliciting robust multi-functional T response in the lung mucus and achieving enhanced mucosal immune protection against pulmonary TB.
Social norms in distressed neighbourhoods: testing the Wilson hypothesis

Poverty or distressed neighbourhoods are assumed to have a negative impact on their residents, e.g. on deviant behaviour. This context effect is reviewed, in particular the work of Wilson (1987). Based upon his assumptions, the paper analyses the impact of distressed neighbourhoods on the acceptance of deviant behaviour by their residents in a sample of four neighbourhoods in Cologne, Germany. Findings support some of Wilson's propositions, in particular the impact of the neighbourhood on the acceptance of deviant behaviour, even when individual variables are controlled. In contrast, the assumed impact of exposure to neighbourhood on deviant norms, measured by time spent in the neighbourhood and total network size, are supported only in bivariate but not multivariate analyses. It is found, however, that total network size and annoyance about deviance are negatively related to acceptance of deviance.
Tightly Coupled Integration of GPS-PPP and MEMS-Based Inertial System Using EKF and UKF

In this paper, an improved Precise Point Positionin g GPS/MEMS-based integrated system is introduced for precise positioning applic ations. Un-differenced ionosphere-free linear combinations of carrier phase and code measu r ments are processed. Tropospheric delay, satellite clock, ocean loading, Earth tide, carrier-phase windup, relativity, and satellite and receiver antenna phase-center variati ons are accounted for using rigorous modeling. Tightly coupled mechanism is adopted, whi ch s carried out in the raw measurements domain. Both Extended Kalman filter (E KF) and Unscented Kalman filter (UKF) are developed to merge the GPS and inertial m easurements. The performance of integrated system is analyzed using a real test sce nario in downtown Kingston.
Viable Borrelia burgdorferi Enhances Interleukin-10 Production and Suppresses Activation of Murine Macrophages

ABSTRACT Although it is capable of eliciting strong innate and adaptive immune responses, Borrelia burgdorferi often evades immune clearance through largely unknown mechanisms. Our previous studies determined that infected interlukin-10−/− (IL-10−/−) mice show significantly lower B. burgdorferi levels than wild-type (B6) mice and that IL-10 inhibits innate immune responses critical for controlling B. burgdorferi infection. To determine whether virulent B. burgdorferi preferentially enhances IL-10 production, we developed an in vitro coculture medium (RPMI.B) in which both B. burgdorferi and primary macrophages (Mφs) remain viable. B. burgdorferi grew at similar rates and was able to regulate expression of immunoreactive proteins with similar kinetics in RPMI.B and in traditional BSK medium; in contrast, B. burgdorferi cultured in conventional tissue culture medium (RPMI) rapidly lost viability. Coculture of viable B. burgdorferi in RPMI.B with Mφs resulted in more rapid and significant increases in IL-10 transcripts and secreted proteins than coculture with nonviable B. burgdorferi in RPMI, which corresponded with decreased production of proinflammatory cytokines. Addition of live B. burgdorferi to Mφs in RPMI.B also elicited substantially higher IL-10 levels than heat-killed bacteria elicited, confirming that increased IL-10 production was not inherent to coculture in RPMI.B. Transfer of supernatants from B. burgdorferi-stimulated Mφs into naïve Mφ cultures resulted in suppressed activation upon subsequent stimulation with different bacterial agonists, and this suppression was obviated by IL-10-specific antibody. In vivo analyses determined that murine skin samples exhibited substantial upregulation of IL-10 within 24 h of injection of B. burgdorferi. Together, these results suggest that viable B. burgdorferi can suppress early Mφ responses during infection by causing increased release of IL-10.
Nanobodies as novel agents for cancer therapy

Nanobodies are the smallest fragments of naturally occurring heavy-chain antibodies that have evolved to be fully functional in the absence of a light chain. As such, the cloning and selection of antigen-specific nanobodies obviate the need for construction and screening of large libraries, and for lengthy and unpredictable invitro affinity maturation steps. The unique and well-characterised properties enable nanobodies to excel conventional therapeutic antibodies in terms of recognising uncommon or hidden epitopes, binding into cavities or active sites of protein targets, tailoring of half-life, drug format flexibility, low immunogenic potential and ease of manufacture. Moreover, the favourable biophysical and pharmacological properties of nanobodies, together with the ease of formatting them into multifunctional protein therapeutics, leaves them ideally placed as a new generation of antibody-based therapeutics. This review describes the state of the art on nanobodies and illustrates their potential as cancer therapeutic agents.
Parallelization of the dynamic programming algorithm for solving the longest common subsequence problem

We address in this paper the design and analysis of cost-optimal parallel algorithms for solving the problem of the longest common subsequence. Starting from the standard sequential dynamic programming algorithm which has the structure of a perfect nest of two embedded loops, we make use of a specific three-step parallelization approach consisting in (i) a dependence analysis within the nest ; (ii) the determination of a particular unimodular transformation leading to a new nest whose second loop is parallel ; (iii) the design of two linear time schedulings for the derived parallel algorithm when a given number of processors is available. The first scheduling is fitted to the nest structure while the second is greedy oriented and optimal. The makespans of the two schedulings are explicitly determined. This permits to establish a comparison showing their respective efficiencies.
Minocycline Modulates Human Social Decision-Making: Possible Impact of Microglia on Personality-Oriented Social Behaviors

Background Microglia, one of the glial cells, play important roles in various brain pathologies including psychiatric disorders. In addition, microglia have recently been proved to monitor synaptic reactions via direct-touching even in normal brain. Human microglia may modulate various social/mental functions, while microglial social/mental roles remain unresolved especially in healthy humans. There is no known drug with the specific effect of modulating microglia. Therefore, using minocycline, a tetracycline antibiotic and the most famous microglial inhibitor, is one of the best alternative approaches to clarify microglial functions on human social/mental activities. Methodology/Principal Findings We conducted a double-blind randomized trial of trust game, a monetary decision-making experiment, with ninety-nine human adult males who decided how much to trust an anonymous partner after a four-day administration of minocycline. Our previous pilot trial indicated a positive effect of minocycline, while the underlying mechanisms were not clarified. Therefore, in this trial with larger samples, we additionally measured the effects of anxiety and personality. The monetary score in trust game was significantly lower in the minocycline group. Interestingly, participants’ ways of decision-making were significantly shifted; cooperativeness, one component of personality, proved to be the main modulating factor of decision-making in the placebo group, on the other hand, the minocycline group was mainly modulated by state anxiety and trustworthiness. Conclusions/Significance Our results suggest that minocycline led to more situation-oriented decision-making, possibly by suppressing the effects of personality traits, and furthermore that personality and social behaviors might be modulated by microglia. Early-life events may activate human microglia, establish a certain neuro-synaptic connection, and this formation may determine each human’s personality and personality- oriented social behaviors in later life. To explore these mechanisms, further translational research is needed. Trial Registration UMIN clinical trial center UMIN000004803
Association between prescription co-payment amount and compliance with adjuvant hormonal therapy in women with early-stage breast cancer.

PURPOSE Noncompliance with adjuvant hormonal therapy among women with breast cancer is common. Little is known about the impact of financial factors, such as co-payments, on noncompliance. PATIENTS AND METHODS We conducted a retrospective cohort study by using the pharmacy and medical claims database at Medco Health Solutions. Women older than age 50 years who were taking aromatase inhibitors (AIs) for resected breast cancer with two or more mail-order prescriptions, from January 1, 2007, to December 31, 2008, were identified. Patients who were eligible for Medicare were analyzed separately. Nonpersistence was defined as a prescription supply gap of more than 45 days without subsequent refill. Nonadherence was defined as a medication possession ratio less than 80% of eligible days. RESULTS Of 8110 women younger than age 65 years, 1721 (21.1%) were nonpersistent and 863 (10.6%) were nonadherent. Among 14,050 women age 65 years or older, 3476 (24.7%) were nonpersistent and 1248 (8.9%) were nonadherent. In a multivariate analysis, nonpersistence (ever/never) in both age groups was associated with older age, having a non-oncologist write the prescription, and having a higher number of other prescriptions. Compared with a co-payment of less than $30, a co-payment of $30 to $89.99 for a 90-day prescription was associated with less persistence in women age 65 years or older (odds ratio [OR], 0.69; 95% CI, 0.62 to 0.75) but not among women younger than age 65, although a co-payment of more than $90 was associated with less persistence both in women younger than age 65 (OR, 0.82; 95% CI, 0.72 to 0.94) and those age 65 years or older (OR, 0.72; 95% CI, 0.65 to 0.80). Similar results were seen with nonadherence. CONCLUSION We found that higher prescription co-payments were associated with both nonpersistence and nonadherence to AIs. This relationship was stronger in older women. Because noncompliance is associated with worse outcomes, future policy efforts should be directed toward interventions that would help patients with financial difficulties obtain life-saving medications.
Ethical leadership, moral equity judgments, and discretionary workplace behavior

The current study examines the role of ethical cognition as a psychological mechanism linking ethical leadership to employee engagement in specific discretionary workplace behaviors. Hypotheses are developed proposing that ethical leadership is associated with employees’ negative moral equity judgments of workplace deviance (a discretionary antisocial behavior) and positive moral equity judgments of organizational citizenship (a discretionary prosocial behavior). In addition, hypotheses propose that moral equity judgments are a key type of ethical cognition linking ethical leadership with employee behaviors. Hypotheses are tested in a cross-organizational sample of 190 supervisor–employee dyads. Results indicate that employees who work for ethical leaders tended to judge acts of workplace deviance as morally inequitable and acts of organizational citizenship as morally equitable. In turn, these judgments guided employee regulation of behavior, and mediated the relationships between ethical leadership and employee avoidance of antisocial conduct and engagement in prosocial behavior.
Effect of sulfur fertilization on chemical composition, ensiling characteristics, and utilization by lambs of sorghum silage.

Effects of S fertilization, 0 or 138 kg of S/ha, as (NH4)2SO4 on chemical composition, ensiling characteristics, and utilization of sorghum (Sorghum bicolor L.) silage by wether lambs was investigated. Pioneer 947' sorghum forage was ensiled at the soft dough growth stage. Sulfur fertilization increased (P < .01) concentrations of S, N, K, Mn, and water-soluble carbohydrates (WSC) and decreased (P < .05) concentrations of Fe, Cu, Al, and acetic acid after ensiling. Sulfur-fertilized sorghum silage (N:S = 12) and non-S fertilized silage (N:S = 15) were fed alone and supplemented with urea to achieve 14% CP (N:S = 18 and 23, respectively) to 24 crossbred (1/2 Dorset, 1/4 Finn, 1/4 Rambouillet) wether lambs in a metabolism trial. Sulfur fertilization decreased apparent lignin digestibility and increased apparent digestibilities of DM, NDF, and hemicellulose (P < .05), apparent absorption and retention of S, N, P, K, Mg, and Mn (P < .01), and apparent absorption of Ca (P < .05). Apparent absorption and retention of Cu and Al were lower (P < .05) in lambs fed the S-fertilized silages. Digestibilities of DM and NDF were increased by N-supplementation in the non S-fertilized silage (N x S interaction, P < .05). Nitrogen supplementation increased (P < .01) blood urea nitrogen and apparent absorption and retention of N. Results indicate that S fertilization enhanced forage quality primarily due to increased TNC concentration, digestibility of hemicellulose, and N utilization by lambs but could exacerbate Cu deficiency where Cu levels are marginal.
New Bounds for the Generalized Marcum  $Q$-Function

In this paper, we study the generalized Marcum <i>Q</i>-function <i>Q</i> <sub>nu</sub>(<i>a</i>, <i>b</i>), where <i>a</i>, nu > 0 and <i>b</i> ges 0. Our aim is to extend the results of Corazza and Ferrari (<i>IEEE</i> <i>Trans.</i> <i>Inf.</i> <i>Theory</i>, vol. 48, pp. 3003-3008, 2002) to the generalized Marcum <i>Q</i>-function in order to deduce some new tight lower and upper bounds. The key tools in our proofs are some monotonicity properties of certain functions involving the modified Bessel function of the first kind and some classical inequalities, i.e., the Cauchy-Buniakowski-Schwarz and Chebyshev integral inequalities. These bounds are shown to be very tight for large <i>b</i>, i.e., the relative errors of our bounds converge to zero as <i>b</i> increases. Both theoretical analysis and numerical results are provided to show the tightness of our bounds.
Parents' Participation in Cultural Practices With Their Preschoolers

In this article we discuss cross-cultural similarities and variations in parents' engagement in the everyday activities in which their preschool-age children engage, focusing on mothers' and fathers' presence in the same setting as their children, the impact of their presence on the types of activities in which the children engaged, and the extent of mothers' and fathers' involvement with their children in those activities. The data were gathered from different societies - the United States, Korea, Russia, Estonia, and Kenya. They reveal that the children were involved primarily in play (more than in lessons, work, or conversation), and this was unaffected by the presence of either parent. However, parents were relatively less likely to be involved in their children's play than in the other activities. Mothers, not surprisingly, were more likely to be found in the same setting as their children and, even when taking account of their greater presence, were more likely to be involved with their children than were fathers.