Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of family budgeting responsibility on subjective health status: An empirical study of Japanese wives

ABSTRACT We examine whether the decision-making power of Japanese wives affects their health status. Looking at cross-sectional data from the Japanese Panel Survey of Consumers (JPSC) conducted with women, we create a new measure for decision-making power based on participation in family budgeting. The data sample covers 1,306 married women aged 25 to 45 years in 2004. We find that Japanese wives are more likely to report good health when they have more responsibility than their husbands for household budgeting. Additionally, having more education or being fully employed increased the probability of reporting “good health” by more than six percentage points.
Temperature insensitive measurements of displacement using fiber Bragg grating sensors

Optical fiber Bragg grating (FBG) displacement sensors play an important role in various areas due to the high sensitivity to displacement. However, it becomes a serious problem of FBG cross-sensitivity of temperature and displacement in applications with FBG displacement sensing. This paper presents a method of temperature insensitive measurement of displacement via using an appropriate layout of the sensor. A displacement sensor is constructed with two FBGs mounted on the opposite surface of a cantilever beam. The wavelengths of the FBGs shift with a horizontal direction displacement acting on the cantilever beam. Displacement measurement can be achieved by demodulating the wavelengths difference of the two FBGs. In this case, the difference of the two FBGs’ wavelengths can be taken in order to compensate for the temperature effects. Four cantilever beams with different shapes are designed and the FBG strain distribution is quite different from each other. The deformation and strain distribution of cantilever beams are simulated by using finite element analysis, which is used to optimize the layout of the FBG displacement sensor. Experimental results show that an obvious increase in the sensitivity of this change on the displacement is obtained while temperature dependence greatly reduced. A change in the wavelength can be found with the increase of displacement from 0 to 10mm for a cantilever beam. The physical size of the FBG displacement sensor head can be adjusted to meet the need of different applications, such as structure health monitoring, smart material sensing, aerospace, etc.
Transit Price Elasticities and Cross-Elasticities

This article summarizes price elasticities and cross-elasticities for use in public transit planning. It describes elasticities and how they are used, and examines previous research on transit elasticities. Commonly used transit elasticity values are largely based on studies of short- and medium-run impacts performed decades ago when real incomes were lower and a larger proportion of the population was transit dependent. As a result, they tend to be lower than appropriate to model long-run impacts. Analysis based on these elasticity values tends to understate the potential of transit fare reductions and service improvements to reduce problems, such as traffic congestion and vehicle pollution, and understates the long-term negative impacts that fare increases and service cuts will have on transit ridership, transit revenue, traffic congestion, and pollution emissions.
Remarkable Increase in Field Effect Mobility of Amorphous IZTO Thin-Film Transistors With Purified ZrOx Gate Insulator

We report the effect of purification of ZrO<sub>x</sub> precursor on the performance of solution processed amorphous indium–zinc–tin oxide thin-film transistors with a ZrO<sub>x</sub> gate insulator, which is processed at the maximum temperature of 300 °C in air. By purification, the saturation mobility (<inline-formula> <tex-math notation="LaTeX">$\mu _{\textit {sat}}$ </tex-math></inline-formula>) increases from 2.45 ± 0.83 to 15.42 ± 4.01 cm<sup>2</sup>V<sup>−1</sup>s<sup>−1</sup>, subthreshold swing decreases from 141.44 ± 14.08 to 87.90 ± 11.05 mV/decade and drain current ON/OFF ratio increases from ~10<sup>7</sup> to ~10<sup>9</sup>. The leakage currents are remarkably reduced by using purified ZrO<sub>x</sub> as a gate insulator. The improvement is mainly due to the reduced impurities and less oxygen vacancies in ZrO<sub>x</sub>.
Simulation of the Injection-Compression Molding Process Using CV/FEM Technique

In the present study, a numerical alogrithm is developed in order to simulate the non-isothermal filling and compression stages of the injection-compression molding process. The generialized Hele-Shaw flow model combined with the control volume/finite element method is implemented to predict the melt front advancement and the distributions of pressure, temperature and flow velocity dynamically during the molding process. From on the simulated results, it was found that the compression speed is the most important factor that affect the molding pressure. Under proper compression speed, the predicted molding pressure is lower than that required by the purely conventional injection molding and the part residual stress can be minimized. It was also found that part temperature is more uniform at the end of filling process by using injection-compression molding. If the switch time from injection to compression is too low, it may also cause high molding pressure.
Bayesian network meta-analysis comparing five contemporary treatment strategies for newly diagnosed acute promyelocytic leukaemia

Acute promyelocytic leukemia (APL) is a curable subtype of acute myeloid leukemia. The optimum regimen for newly diagnosed APL remains inconclusive. In this Bayesian network meta-analysis, we compared the effectiveness of five regimens-arsenic trioxide (ATO) + all-trans retinoic acid (ATRA), realgar-indigo naturalis formula (RIF) which contains arsenic tetrasulfide + ATRA, ATRA + anthracycline-based chemotherapy (CT), ATO alone and ATRA alone, based on fourteen randomized controlled trials (RCTs), which included 1407 newly diagnosed APL patients. According to the results, the ranking efficacy of the treatment, including early death and complete remission in the induction stage, was the following: 1. ATO/RIF + ATRA; 2. ATRA + CT; 3. ATO, and 4. ATRA. For long-term benefit, ATO/RIF + ATRA significantly improved overall survival (OS) (hazard ratio = 0.35, 95%CI 0.15–0.82, p = 0.02) and event-free survival (EFS) (hazard ratio = 0.32, 95%CI 0.16–0.61, p = 0.001) over ATRA + CT regimen for the low-to-intermediate-risk patients. Thus, ATO + ATRA and RIF + ATRA might be considered the optimum treatments for the newly diagnosed APL and should be recommended as the standard care for frontline therapy.
Message queue telemetry transport protocols implementation for wireless sensor networks communication — A performance review

Message Queue Telemetry Transport (MQTT) is a protocol with publish/subscribe interactions schemes and have a lightweight feature that suited for a constrained environment such in Wireless Sensor Network. This Paper presents the result of MQTT Protocols implementation in a Wireless Sensor Network (WSN) where Arduino and NRF24L01 were acted as WSN nodes, while the gateway consists of Arduino, NRF24L01 and ESP8266 Wi-Fi module as the IP based interface to the MQTT Broker. Sensor node and gateway interaction schemes were built using MQTT-SN protocols with different quality of Service (QoS) types which are QoS 0, QoS 1, and QoS 2. This paper measured several parameters which are gateway discovery process, the total number of packet loss in QoS0, data duplication along with total number of re-tries and Round-Trip Time (RTT) delay in QoS1 & QoS2. Based on the experiment, this research found several results. First, the average time for gateway discovery process is 1123.40 ms. Second, The QoS 0 is the fastest publish type protocol. However, the QoS 0 is unreliable. The QoS 0 publish type is having the most packet loss message based our experiment. Third, The QoS1 packet loss is better than QoS0 but the data duplication and several numbers of re-tries are found. Last, The QoS2 is the slowest publish type but most reliable publish message transfer. The experiment result that no packet loss occurred and the duplication data can be ignored by the gateway.
Estrogen activation of microglia underlies the sexually dimorphic differences in Nf1 optic glioma–induced retinal pathology

Children with neurofibromatosis type 1 (NF1) develop low-grade brain tumors throughout the optic pathway. Nearly 50% of children with optic pathway gliomas (OPGs) experience visual impairment, and few regain their vision after chemotherapy. Recent studies have revealed that girls with optic nerve gliomas are five times more likely to lose vision and require treatment than boys. To determine the mechanism underlying this sexually dimorphic difference in clinical outcome, we leveraged Nf1 optic glioma (Nf1-OPG) mice. We demonstrate that female Nf1-OPG mice exhibit greater retinal ganglion cell (RGC) loss and only females have retinal nerve fiber layer (RNFL) thinning, despite mice of both sexes harboring tumors of identical volumes and proliferation. Female gonadal sex hormones are responsible for this sexual dimorphism, as ovariectomy, but not castration, of Nf1-OPG mice normalizes RGC survival and RNFL thickness. In addition, female Nf1-OPG mice have threefold more microglia than their male counterparts, and minocycline inhibition of microglia corrects the retinal pathology. Moreover, pharmacologic inhibition of microglial estrogen receptor-&bgr; (ER&bgr;) function corrects the retinal abnormalities in female Nf1-OPG mice. Collectively, these studies establish that female gonadal sex hormones underlie the sexual dimorphic differences in Nf1 optic glioma–induced retinal dysfunction by operating at the level of tumor-associated microglial activation.
Nine new species of the spider genus Stedocys (Araneae, Scytodidae) from China and Thailand

Nine new species of the genus Stedocys Ono, 1995 are described: Stedocys gaolingensis Wu & Li sp. n. (♂♀, Guangxi), S. huangniuensis Wu & Li sp. n. (♀, Guangxi), S. ludiyanensis Wu & Li sp. n. (♂♀, Guangxi), S. matuoensis Wu & Li sp. n. (♀, Guangxi), S. pulianensis Wu & Li sp. n. (♂, Guangxi), S. shilinensis Wu & Li sp. n. (♂♀, Hainan), S. xianrenensis Wu & Li sp. n. (♂♀, Guangxi), S. xiangzhouensis Wu & Li sp. n. (♂♀, Guangxi) from China, and S. zhaoi Wu & Li sp. nov. (♂♀, Kanchanaburi) from Thailand. Diagnoses of nine new species are provided. DNA barcodes for six new species are documented for future use and as proof of molecular differences between these species.
Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting

Antibody therapy is a validated treatment approach for several malignancies. All currently clinically applied therapeutic antibodies (Abs) are of the IgG isotype. However, not all patients respond to this therapy and relapses can occur. IgA represents an alternative isotype for antibody therapy that engages FcαRI expressing myeloid effector cells, such as neutrophils and monocytes. IgA Abs have been shown to effectively kill tumor cells both in vitro and in vivo. However, due to the short half-life of IgA Abs in mice, daily injections are required to reach an effect comparable to IgG Abs. The relatively long half-life of IgG Abs and serum albumin arises from their capability of interacting with the neonatal Fc receptor (FcRn). As IgA Abs lack a binding site for FcRn, we generated IgA Abs with the variable regions of the Her2-specific Ab trastuzumab and attached an albumin-binding domain (ABD) to the heavy or light chain (HCABD/LCABD) to extend their serum half-life. These modified Abs were able to bind albumin from different species in vitro. Furthermore, tumor cell lysis of IgA-Her2-LCABD Abs in vitro was similar to unmodified IgA-Her2 Abs. Pharmacokinetic studies in mice revealed that the serum exposure and half-life of the modified IgA-Her2 Abs was extended. In a xenograft mouse model, the modified IgA1 Abs exhibited a slightly, but significantly, improved anti-tumor response compared to the unmodified Ab. In conclusion, empowering IgA Abs with albumin-binding capacity results in in vitro and in vivo functional Abs with an enhanced exposure and prolonged half-life.
Closing in on the Mechanisms of Pulsatile Insulin Secretion

Insulin secretion from pancreatic islet β-cells occurs in a pulsatile fashion, with a typical period of ∼5 min. The basis of this pulsatility in mouse islets has been investigated for more than four decades, and the various theories have been described as either qualitative or mathematical models. In many cases the models differ in their mechanisms for rhythmogenesis, as well as other less important details. In this Perspective, we describe two main classes of models: those in which oscillations in the intracellular Ca2+ concentration drive oscillations in metabolism, and those in which intrinsic metabolic oscillations drive oscillations in Ca2+ concentration and electrical activity. We then discuss nine canonical experimental findings that provide key insights into the mechanism of islet oscillations and list the models that can account for each finding. Finally, we describe a new model that integrates features from multiple earlier models and is thus called the Integrated Oscillator Model. In this model, intracellular Ca2+ acts on the glycolytic pathway in the generation of oscillations, and it is thus a hybrid of the two main classes of models. It alone among models proposed to date can explain all nine key experimental findings, and it serves as a good starting point for future studies of pulsatile insulin secretion from human islets.
Lipid Changes Around the Final Menstrual Period Predict Carotid Subclinical Disease in Postmenopausal Women

Background and Purpose— Atherogenic changes in lipids occur among women around the time of the natural menopause, that is, within 1 year of the final menstrual period (FMP). We investigated whether lipid changes around the FMP are related to carotid intima-media thickness, interadventitial diameter, and plaque in postmenopausal women. Methods— A total of 863 natural postmenopausal women with no history of heart attack or stroke underwent carotid ultrasound scans at follow-up year 12 or 13 of the Study of Women’s Health Across the Nation. Estimates of their annual change in lipids were segmented into the year before and after the FMP, before the year before FMP, and 1 year after FMP. Multivariate analyses were adjusted for sociodemographic characteristics, time from FMP to scan, baseline body mass index and systolic blood pressure, and use of medications for hypertension and diabetes mellitus at the scan. Results— Smaller increases in high-density lipoprotein cholesterol and apolipoprotein A1 within 1 year of the FMP were related to greater interadventitial diameter, &bgr; (SE)=−0.036 (0.015), P=0.02, and &bgr; (SE)=−0.035 (0.013), P=0.006, respectively. Greater increases in low-density lipoprotein cholesterol within 1 year of FMP were related to greater likelihood of plaque scores ≥2, odds ratio, 1.071; 95% confidence interval, 1.018–1.127; P=0.009. Magnitude of associations was reduced but remained significant with further adjustment for premenopausal lipid levels. The difference in probability of elevated plaque scores was 50% between those in the highest and lowest low-density lipoprotein cholesterol change tertiles. Conclusions— Changes in lipids as women approach the FMP provide useful clinical information for understanding postmenopausal carotid indices.
Nondestructive Detection of Internal Delamination by Vibration-based Method for Composite Plates

A method for locating internal delamination in multilayer composite plates is presented. A finite element method for composite plates is developed to investigate the relationship between delamination and change of modal parameters. The mechanism of the mode-dependent energy dissipation of composite plates is revealed by numerical analysis of delamination-induced variations of modal parameters. Experiments are carried out using piezoelectric actuator and accelerometer to measure the dynamic response to sinusoidal sweep excitation for several cantilever composite plates. The results show that the region of internal delamination in composite plates can be predicted according to the measured acceleration response and the computed modal strain energy.
Atypical chemokine receptor CCRL2 is overexpressed in prostate cancer cells

Atypical chemokine receptors have recently emerged as important molecular players in health and diseases; they affect chemokine availability and function and impact a multitude of pathophysiological events, including the tumorigenesis process. This family of atypical receptors comprises five members: ACKR1/DARC, ACKR2/D6, ACKR3/CXCR7, ACKR4/CCRL1, and ACKR5/CCRL2. This work evaluated the differential expression of these receptors in prostate cancer using quantitative PCR. Further evaluation of CCRL2 at the protein level confirmed its overexpression in a metastatic cell line and in malignant prostatic tissues from patients. CCRL2, a presumed member of the atypical chemokine receptor family, plays a key role in lung dendritic cell trafficking to peripheral lymph nodes. Recent studies have reported the expression of CCRL2 in different human cancer cell lines and tissues. However, its function and expression in prostate cancer has not been previously addressed.
Descemetorhexis Without Endothelial Keratoplasty (DWEK): Proposal for Nomenclature Standardization.

study over one year. Am J Ophthalmol. 2016; 167:38–47. 11. De Bernardo M, Cornetta P, Rosa N. Safety and efficacy of sequential intracorneal ring segment implantation and cross-linking in pediatric keratoconus. Am J Ophthalmol. 2017;181:182–183. 12. Rosa N, De Bernardo M, Borrelli M, et al. Effect of oxybuprocaine eye drops on corneal volume and thickness measurements. Optom Vis Sci. 2011;88:640–644.
Methionine oxidized apolipoprotein A‐I at the crossroads of HDL biogenesis and amyloid formation

Apolipoprotein A‐I (apoA‐I) shares with other exchangeable apolipoproteins a high level of structural plasticity. In the lipid‐free state, the apolipoprotein amphipathic a‐helices interact intra‐ and intermolecularly, providing structural stabilization by self‐association. We have reported that lipid‐free apoA‐I becomes amyloidogenic upon physiologically relevant (myeloperoxidase‐mediated) Met oxidation. In this study, we established that Met oxidation promotes amyloidogenesis by reducing the stability of apoA‐I monomers and irreversibly disrupting selfassociation. The oxidized apoA‐I monomers also exhibited increased cellular cholesterol release capacity and stronger association with macrophages, compared to nonoxidized apoA‐I. Of physiologic relevance, preformed oxidized apoA‐I amyloid fibrils induced amyloid formation in nonoxidized apoA‐I. This process was enhanced when self‐association of nonoxidized apoA‐I was disrupted by thermal treatment. Solid state NMR analysis revealed that aggregates formed by seeded nonoxidized apoA‐I were structurally similar to those formed by the oxidized protein, featuring a β‐structure‐rich amyloid fold alongside a‐helices retained from the native state. In atherosclerotic lesions, the conditions that promote apoA‐I amyloid formation are readily available: myeloperoxidase, active oxygen species, low pH, and high concentration of lipid‐free apoA‐I. Our results suggest that even partial Met oxidation of apoA‐I can nucleate amyloidogenesis, thus sequestering and inactivating otherwise antiatherogenic and HDL‐forming apoA‐I. —Witkowski, A. , Chan, G. K. L. , Boatz, J. C. , Li, N. J., Inoue, A. P., Wong, J. C. , van der Wel, P. C. A. , Cavigiolio, G. Methionine oxidized apolipoprotein A‐I at the crossroads of HDL biogenesis and amyloid formation. FASEB J. 32, 3149–3165 (2018). www.fasebj. org
Survival rate of modern all-ceramic FPDs during an observation period from 2011 to 2016

PURPOSE In literature, many studies compare survival rates of different types of FPDs. Most of them compared restorations, which originated from one university, but from different clinicians. Data about restoration survival rates by only one experienced dentist are very rare. The aim of this study was to evaluate the survival rate of allceramic FPDs without the blurring effects of different clinicians. MATERIALS AND METHODS 153 veneeredzirconia FPDs were observed for follow-up. 22 patients received 131 single crowns and 22 bridges. Because of the different bridge lengths, one unit was defined as a restored or replaced tooth. In total, 201 units were included. Only the restorations performed by the same clinician and produced in the same dental laboratory from 2011 to 2016 were included. Considered factors were defined as “type of unit”, “type of abutment”, “intraoral region”, and “vitality”. Modified UHPHS criteria were used for evaluation. Statistical analysis was performed using cox-regression. RESULTS 189 units (94.0%) showed no kind of failure. 5 chippings (2.4%) could be corrected by intraoral polishing. 4 units (1.9%) exhibited spontaneous decementation. These polishable and recementable restorations are still in clinical use. Chippings or decementations, which lead to total failure, did not occur. One unit was completely fractured (0.5 %). Biological failures (caries, periodontitis or periimplantitis) did not occur. The statistical analysis of the factors did not reveal any significant differences. CONCLUSION Modern all-ceramic FPDs seem to be an appropriate therapy not only for single restorations but for complex occlusal rehabilitations.
Physician report of industry gifts and quality of care

Background: Physician financial conflict of interest is a concern in the delivery of medicine because of its possible influence on the cost and the quality of patient care. There has been an extensive discussion of the ethical, economic, and legal aspects of this issue but little direct empirical evidence of its magnitude or effects. Methodology: A nationally representative survey (n = 4,720) was used to empirically examine physician self-report of receipt of financial gifts from the pharmaceutical and medical devices industry and its association with their ability to provide quality care. Findings: Results indicate that the vast majority of physicians receive industry gifts in various forms, and the receipt of gifts is associated with lower perceived quality of patient care. There is also an inverse relationship between the frequency of received gifts and the perceived quality of care. Practice Implications: Physicians need to be aware of the widespread receipt of industry gifts in medical practice and the potential adverse impact of such receipts on the delivery of care.
Attentional modulation of neuronal variability in circuit models of cortex

The circuit mechanisms behind shared neural variability (noise correlation) and its dependence on neural state are poorly understood. Visual attention is well-suited to constrain cortical models of response variability because attention both increases firing rates and their stimulus sensitivity, as well as decreases noise correlations. We provide a novel analysis of population recordings in rhesus primate visual area V4 showing that a single biophysical mechanism may underlie these diverse neural correlates of attention. We explore model cortical networks where top-down mediated increases in excitability, distributed across excitatory and inhibitory targets, capture the key neuronal correlates of attention. Our models predict that top-down signals primarily affect inhibitory neurons, whereas excitatory neurons are more sensitive to stimulus specific bottom-up inputs. Accounting for trial variability in models of state dependent modulation of neuronal activity is a critical step in building a mechanistic theory of neuronal cognition. DOI: http://dx.doi. org/10.7554/eLife.23978. 001