Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental Infection of Calves with Bovine Viral Diarrhea Virus Genotype II (NY-93)

To ascertain the virulence of bovine viral diarrhea virus (BVDV) genotype II, isolate NY-93 was inoculated intranasally into 3 calves, 2 of which were treated with a synthetic glucocorticoid prior to and after virus inoculation. Anorexia, fever (up to 42 C), dyspnea, and hemorrhagic diarrhea developed 6 days after intranasal inoculation with BVDV NY-93. The condition of all calves deteriorated further until the end of the study on day 14 postinoculation. The most significant postmortem macroscopic changes in all calves were limited to the gastrointestinal tract and consisted of moderate to severe congestion of the mucosa with multifocal hemorrhages. Microscopic lesions found in the gastrointestinal tract were similar to those observed in mucosal disease, including degeneration and necrosis of crypt epithelium and necrosis of lymphoid tissue throughout the ileum, colon, and rectum. The basal stratum of the epithelium of tongue, esophagus, and rumen had scattered individual necrotic cells. Spleen and lymph nodes had lymphocytolysis and severe lymphoid depletion. Severe acute fibrinous bronchopneumonia was present in dexamethasone-treated calves. Abundant viral antigen was detected by immunohistochemistry in the squamous epithelium of tongue, esophagus, and forestomachs. BVDV antigen was prominent in cells of the media of small arteries and endothelial cells. The presence of infectious virus in tissues correlated with an absence of circulating neutralizing antibodies. These findings highlight the potential of BVDV genotype II to cause severe disease in normal and stressed cattle.
Ab initio calculations of NMR spin-Hamiltonian parameters for the polyamines of prostate tissue

1H nuclear magnetic resonance NMR spin-Hamiltonian parameters: chemical shifts delta and spin-spin coupling constants J have been calculated for the three polyamines: putrescine, spermidine and spermine present in prostate tissue using density functional theory. Molecules in the gas-phase as well as in solution in water were investigated. From calculated delta and J values, NMR spectra were simulated and compared to experimental ones acquired at 400 MHz for each polyamine in solution in D2O. From these comparisons, reliable NMR parameters are proposed for putrescine, spermidine and spermine.
Decentralized Coordination of Microgrids With Flexible Demand and Energy Storage

Scalability and privacy concerns have created significant interest in decentralized coordination of distributed energy resources (DERs) within microgrids. Previously proposed approaches, however, fail to achieve feasible solutions under flexible demand (FD) and energy storage (ES) participation. After justifying and demonstrating this challenge, this paper develops a novel Lagrangian relaxation-based mechanism achieving feasible, near-optimal solutions in a decentralized fashion, considering both active and reactive power. A two-level iterative algorithm eliminates the infeasibility effect of FD and ES nonstrict convexities, and prevents the creation of new demand peaks and troughs by the concentration of their response at the same low- and high-priced periods. Tradeoffs associated with the design and operation of the mechanism are analyzed, and the value of additional information submission by the DER, in enabling the quantification of an optimality bound of the determined solutions and significant improvements in communication requirements, is assessed. These contributions are supported by case studies on an LV microgrid test system.
SCARNA: fast and accurate structural alignment of RNA sequences by matching fixed-length stem fragments

MOTIVATION The functions of non-coding RNAs are strongly related to their secondary structures, but it is known that a secondary structure prediction of a single sequence is not reliable. Therefore, we have to collect similar RNA sequences with a common secondary structure for the analyses of a new non-coding RNA without knowing the exact secondary structure itself. Therefore, the sequence comparison in searching similar RNAs should consider not only their sequence similarities but also their potential secondary structures. Sankoff's algorithm predicts the common secondary structures of the sequences, but it is computationally too expensive to apply to large-scale analyses. Because we often want to compare a large number of cDNA sequences or to search similar RNAs in the whole genome sequences, much faster algorithms are required. RESULTS We propose a new method of comparing RNA sequences based on the structural alignments of the fixed-length fragments of the stem candidates. The implemented software, SCARNA (Stem Candidate Aligner for RNAs), is fast enough to apply to the long sequences in the large-scale analyses. The accuracy of the alignments is better or comparable with the much slower existing algorithms. AVAILABILITY The web server of SCARNA with graphical structural alignment viewer is available at http://www.scarna. org/.
A Taxonomy of Network and Computer Attacks Based on Responses

In order to solve the problem of building corresponding relationship between attacks and responses scientifically in AIR (Automated Intrusion Response) systems, a taxonomy of network and computer attacks based on response is proposed in this paper. Through analyzing existing researches in attack classification and the special need in intrusion response, the new attack taxonomy is constructed by classifying attacks into three main dimensions and subdividing them from the perspectives of response. The first dimension is aimed to classify localities attacks initiate, the second dimension covers all possible methods attackers adopt, and the classification criteria of the third dimension is selected to highlight harms attacks cause. Through using this taxonomy, the relationship between responses and attacks in AIR systems is built successfully. A case study applies it to typical attacks demonstrates its usefulness. Empirical results show this taxonomy is practicable and useful.
An Empirical Investigation of the Influence of a Type of Side Effects on Program Comprehension

This paper reports the results of a study on the impact of a type of side effect (SE) upon program comprehension. We applied a crossover design on different tests involving fragments of C code that include increment and decrement operators. Each test had an SE version and a side-effect-free counterpart. The variables measured in the treatments were the number of correct answers and the time spent in answering. The results show that the side-effect operators considered significantly reduce performance in comprehension-related tasks, providing empirical justification for the belief that side effects are harmful.
Time-dependent visual adaptation for fast realistic image display

Human vision takes time to adapt to large changes in scene intensity, and these transient adjustments have a profound effect on visual appearance. This paper offers a new operator to include these appearance changes in animations or interactive real-time simulations, and to match a user's visual responses to those the user would experience in a real-world scene. Large, abrupt changes in scene intensities can cause dramatic compression of visual responses, followed by a gradual recovery of normal vision. Asymmetric mechanisms govern these time-dependent adjustments, and offer adaptation to increased light that is much more rapid than adjustment to darkness. We derive a new tone reproduction operator that simulates these mechanisms. The operator accepts a stream of scene intensity frames and creates a stream of color display images. All operator components are derived from published quantitative measurements from physiology, psychophysics, color science, and photography. ept intentionally simple to allow fast computation, the operator is meant for use with real-time walk-through renderings, high dynamic range video cameras, and other interactive applications. We demonstrate its performance on both synthetically generated and acquired “real-world” scenes with large dynamic variations of illumination and contrast.
An ecological cost associated with protective symbionts of aphids

Beneficial symbioses are widespread and diverse in the functions they provide to the host ranging from nutrition to protection. However, these partnerships with symbionts can be costly for the host. Such costs, so called “direct costs”, arise from a trade-off between allocating resources to symbiosis and other functions such as reproduction or growth. Ecological costs may also exist when symbiosis negatively affects the interactions between the host and other organisms in the environment. Although ecological costs can deeply impact the evolution of symbiosis, they have received little attention. The pea aphid Acyrthosiphon pisum benefits a strong protection against its main parasitoids from protective bacterial symbionts. The ecological cost of symbiont-mediated resistance to parasitism in aphids was here investigated by analyzing aphid behavior in the presence of predatory ladybirds. We showed that aphids harboring protective symbionts expressed less defensive behaviors, thus suffering a higher predation than symbiont-free aphids. Consequently, our study indicates that this underlined ecological cost may affect both the coevolutionary processes between symbiotic partners and the prevalence of such beneficial bacterial symbionts in host natural populations.
Fast multilevel floorplanning for large scale modules

With the advance of deep sub-micron, current methods are not effective to obtain acceptable layout for large scale modules. Hence, it is important to provide designers of SoC with a powerful floorplanner. In traditional approaches, it is common to simultaneously utilize clustering and declustering technologies, i.e. multiple phases to refine the solution quality. We propose a top-down multilevel genetic floorplanning algorithm to handle the floorplanning and packing for large scale modules. The algorithm is simple and only needs the clustering phase. Experimental results show significantly better running time and promising solutions in comparison with other state-of-the-art research works.
Scaling-up of a HepaRG progenitor cell based bioartificial liver: optimization for clinical application and transport

A new generation of bioartificial livers, based on differentiated proliferative hepatocyte sources, has been developed. Several practicable and regulatory demands have to be addressed before these can be clinically evaluated. We identified three main hurdles: (1) expansion and preservation of the biocomponent, (2) development of scaled-up culture conditions and (3) transport of the device to the bedside. In this study we address these three issues for the HepaRG-progenitor cell line-loaded AMC-Bioartificial Liver. (1) HepaRG cells were expanded in large quantities and then cryopreserved or loaded directly into bioreactors. After 3 weeks of culture, key hepatic functions (ammonia/lactate elimination, apolipoprotein A1 synthesis and cytochrome P450 3A4 activity) did not differ significantly between the two groups. (2) Bioartificial livers were scaled up from 9 ml to 540 ml priming volume, with preservation of normalized hepatic functionality. Quantification of amino acid consumption revealed rapid depletion of several amino acids. (3) Whole-device cryopreservation and cooled preservation induced significant loss of hepatic functionality, whereas simulated transport from culture-facility to the bedside in a clinical-grade transport unit with controlled temperature maintenance, medium perfusion and gas supply did not affect functionality. In addition, we assessed tumorigenicity of HepaRG cells in immune-incompetent mice and found no tumor formation of HepaRG cells (n = 12), while HeLa cells induced formation of carcinomas in eight out of 12 mice in 140 days.
Playing with the Multiple Intelligences: How Play Helps Them Grow.

Howard Gardner first posited a list of “multiple intelligences” as a liberating alternative to the assumptions underlying traditional IQ testing in his widely read study Frames of Mind (1983). Play has appeared only in passing in Gardner’s thinking about intelligence, however, even though play instructs and trains the verbal, interpersonal, intrapersonal, logical, spatial, musical, and bodily intelligences that Gardner regards as original human endowments. Playing out of doors also enhances and exercises the faculty that Gardner later marked as the naturalist intelligence. As recess dwindles in American schools, and as free play shrinks in the childhood experience, this article finds fresh cause to inspect the merits of multiple-intelligence theory through the lens of play.
Reduced Bone Mineral Density and Radial Bone Growth in Young Rabbits Treated with Dexamethasone Eye Drops

Objective: To investigate the effect of dexamethasone eye drops on bone metabolism in newborn rabbits. Methods: Thirty-four 3-week-old rabbits had unilateral clear lens extraction and were randomized into three groups. Postoperatively, group 1 received high-dose and group 2 low-dose dexamethasone eye drops (average doses 0.27 and 0.10 mg/kg body weight/day, respectively). These rabbits also received a postoperative subconjunctival injection of betamethasone. Group 3 (control) received vehicle eye drops only. After 8 weeks of treatment, all animals were killed and the left femurs were isolated and subjected to peripheral quantitative computerized tomography (pQCT) and dual X-ray absorptiometry (DXA) analyses. Results: DXA showed that rabbits treated with either a high or low dose of dexamethasone eye drops had significantly reduced areal bone mineral density (BMD), area and total bone mineral content (BMC) of the femur. Measurements with pQCT demonstrated a dose-dependent reduction in cortical BMC, cortical volumetric BMD and cortical area. These effects were associated with an inhibition of radial femur growth, cortical thickness and periosteal and endosteal circumferences. Conclusion: Dexamethasone eye drops have systemic effects affecting several bone parameters in young rabbits. Any long-term systemic effects of ocular glucocorticoids need to be further studied.
Differential strength of sex‐biased hybrid inferiority in impeding gene flow may be a cause of Haldane's rule

Abstract In animals, if one sex of the F1 hybrid between two species is sterile or inviable, it is usually the heterogametic (XY or WZ) sex. This phenomenon, known as Haldane's rule, is currently thought to be coincidentally caused by different mechanisms in separate entities. The following questions have never been asked: Are heterogametic and homogametic inferiority (sterility or inviability) equivalent as isolating mechanisms? Could discrepancies between them, if existing, produce Haldane's rule? Here I consider sex‐biased hybrid inferiority strictly as an isolating mechanism, and quantitatively evaluate its strength in impeding gene flow. The comparison reveals that the ability of sex‐biased inferiority to impede gene flow varies according to the sex and chromosome involved. Heterogametic inferiority is a weaker barrier when unidirectional and a much stronger one when in compound reciprocal directions, compared with homogametic inferiority. Such differential strength may affect divergence in speciation and produce Haldane's rule.
The wiring diagram of a glomerular olfactory system

The sense of smell enables animals to react to long-distance cues according to learned and innate valences. Here, we have mapped with electron microscopy the complete wiring diagram of the Drosophila larval antennal lobe, an olfactory neuropil similar to the vertebrate olfactory bulb. We found a canonical circuit with uniglomerular projection neurons (uPNs) relaying gain-controlled ORN activity to the mushroom body and the lateral horn. A second, parallel circuit with multiglomerular projection neurons (mPNs) and hierarchically connected local neurons (LNs) selectively integrates multiple ORN signals already at the first synapse. LN-LN synaptic connections putatively implement a bistable gain control mechanism that either computes odor saliency through panglomerular inhibition, or allows some glomeruli to respond to faint aversive odors in the presence of strong appetitive odors. This complete wiring diagram will support experimental and theoretical studies towards bridging the gap between circuits and behavior.
Relationship Between LTE Broadcast/eMBMS and Next Generation Broadcast Television

This paper discusses the relationship between long-term evolution evolved multimedia broadcast/multicast service and next generation broadcast television. Many of the techniques that are well known within one technology are applicable to the other. Potentially, both systems may benefit from the techniques applied in the other. Some examples are provided and discussed. The implications for long-term spectrum planning are considered. Some recommendations are made with respect to appropriate actions to maximize the efficiency of the respective systems.
Survival of leptospires in commercial blood culture systems revisited

Aim—To assess the ability of commercial blood culture systems to maintain leptospires. Methods—Nine different commercial blood culture bottles were compared for their ability to maintain four leptospiral strains at two temperatures, 30°C and 37°C. Bottles were subcultured at 48 hours, and one, two, three, and four week intervals and examined microscopically for the presence of viable leptospires. Results—The results were comparable with those of an earlier study, which showed that different commercial blood culture systems varied in their ability to maintain leptospires. Conclusions—No single factor appears to influence the viability of leptospires in blood culture systems. In general, the combination of an aerobic blood culture and an incubation temperature of 30°C enhances the viability of leptospires, and hence would increase the chances of their subsequent isolation from suspected cases of leptospiraemia.
Protestant Modernity: Weber, Secularisation, and Protestantism

Max Weber's sociological theories of secularization have vastly influenced the study of Protestant belief. "Protestant Modernity" offers a multifaceted understanding of secularization within the broader context of nineteenth-century liberal Protestantism. Anthony J. Carroll reconstructs Weber's original writings to highlight Protestant motifs, reviews current secularization theories, and settles debates about contested meanings of secularization in a volume that will be essential reading for students and scholars of theology and the sociology of religion.
Detecting coplanar feature points in handheld image sequences

3D reconstruction applications can benefit greatly from knowledge about coplanar feature points. Extracting this knowledge from images alone is a difficult task, however. The typical approach to this problem is to search for homographies in a set of point correspondences using the RANSAC algorithm. In this work we focus on two open issues with a blind random search. First, we enforce the detected planes to represent physically present scene planes. Second, we propose methods to identify cases, in which a homography does not imply coplanarity of feature points. Experiments are performed to show applicability of the presented plane detection algorithms to handheld image sequences.
Indirect Comparisons: A Review of Reporting and Methodological Quality

Background The indirect comparison of two interventions can be valuable in many situations. However, the quality of an indirect comparison will depend on several factors including the chosen methodology and validity of underlying assumptions. Published indirect comparisons are increasingly more common in the medical literature, but as yet, there are no published recommendations of how they should be reported. Our aim is to systematically review the quality of published indirect comparisons to add to existing empirical data suggesting that improvements can be made when reporting and applying indirect comparisons. Methodology/Findings Reviews applying statistical methods to indirectly compare the clinical effectiveness of two interventions using randomised controlled trials were eligible. We searched (1966–2008) Database of Abstracts and Reviews of Effects, The Cochrane library, and Medline. Full review publications were assessed for eligibility. Specific criteria to assess quality were developed and applied. Forty-three reviews were included. Adequate methodology was used to calculate the indirect comparison in 41 reviews. Nineteen reviews assessed the similarity assumption using sensitivity analysis, subgroup analysis, or meta-regression. Eleven reviews compared trial-level characteristics. Twenty-four reviews assessed statistical homogeneity. Twelve reviews investigated causes of heterogeneity. Seventeen reviews included direct and indirect evidence for the same comparison; six reviews assessed consistency. One review combined both evidence types. Twenty-five reviews urged caution in interpretation of results, and 24 reviews indicated when results were from indirect evidence by stating this term with the result. Conclusions This review shows that the underlying assumptions are not routinely explored or reported when undertaking indirect comparisons. We recommend, therefore, that the quality of indirect comparisons should be improved, in particular, by assessing assumptions and reporting the assessment methods applied. We propose that the quality criteria applied in this article may provide a basis to help review authors carry out indirect comparisons and to aid appropriate interpretation.
Multipath radar tracking with large uncertainty in the environment

We formulate the target tracking problem for radar in a multipath environment where significant uncertainty on the locations of the multipath causing obstacles (walls) is present. Most of the recent efforts towards investigating target tracking in multipath environments assume knowledge of these wall locations. Relaxing this assumption makes the tracking problem very challenging. We propose a statistical filter (tracker) and a data association method based on importance sampling to address these challenges.
Discs Large Homolog 1 Splice Variants Regulate p38 –Dependent and –Independent Effector Functions in CD8+ T Cells

Functionally diverse CD8+ T cells develop in response to antigenic stimulation with differing capacities to couple TCR engagement to downstream signals and functions. However, mechanisms of diversifying TCR signaling are largely uncharacterized. Here we identified two alternative splice variants of scaffold protein Dlg1, Dlg1AB and Dlg1B, that diversify signaling to regulate p38 –dependent and –independent effector functions in CD8+ T cells. Dlg1AB, but not Dlg1B associated with Lck, coupling TCR stimulation to p38 activation and proinflammatory cytokine production. Conversely, both Dlg1AB and Dlg1B mediated p38-independent degranulation. Degranulation depended on a Dlg1 fragment containing an intact Dlg1SH3-domain and required the SH3-ligand WASp. Further, Dlg1 controlled WASp activation by promoting TCR-triggered conformational opening of WASp. Collectively, our data support a model where Dlg1 regulates p38-dependent proinflammatory cytokine production and p38-independent cytotoxic granule release through the utilization of alternative splice variants, providing a mechanism whereby TCR engagement couples downstream signals to unique effector functions in CD8+ T cells.