Miracle-dz/UniFAR-FTUs huggingface dataset:
Aqueous phase hydration and hydrate acidity of perfluoroalkyl and n:2 fluorotelomer aldehydes

ABSTRACT The SPARC software program and comparative density functional theory (DFT) calculations were used to investigate the aqueous phase hydration equilibrium constants (Khyd) of perfluoroalkyl aldehydes (PFAlds) and n:2 fluorotelomer aldehydes (FTAlds). Both classes are degradation products of known industrial compounds and environmental contaminants such as fluorotelomer alcohols, iodides, acrylates, phosphate esters, and other derivatives, as well as hydrofluorocarbons and hydrochlorofluorocarbons. Prior studies have generally failed to consider the hydration, and subsequent potential hydrate acidity, of these compounds, resulting in incomplete and erroneous predictions as to their environmental behavior. In the current work, DFT calculations suggest that all PFAlds will be dominantly present as the hydrated form in aqueous solution. Both SPARC and DFT calculations suggest that FTAlds will not likely be substantially hydrated in aquatic systems or in vivo. PFAld hydrates are expected to have pKa values in the range of phenols (ca. 9 to 10), whereas n:2 FTAld hydrates are expected to have pKa values ca. 2 to 3 units higher (ca. 12 to 13). In order to avoid spurious modeling predictions and a fundamental misunderstanding of their fate, the molecular and/or dissociated hydrate forms of PFAlds and FTAlds need to be explicitly considered in environmental, toxicological, and waste treatment investigations. The results of the current study will facilitate a more complete examination of the environmental fate of PFAlds and FTAlds.
Comparing harmonic functions and potential fields in the trajectory control of mobile robots

Potential field is a reactive method that has been used for trajectory control of mobile robots. In this method the robot behaves like a particle moving under the influence of an artificial potential produced by the target and the obstacles. This method has lower computational cost than others that utilize maps as a world model. However, one problem or this method is that it can generate regions of local minima. In these regions the driving force vanishes due to specific obstacle and goal configurations and the robot gets trapped. The use of harmonic functions for the potential calculation can solve this problem. In the harmonic function method the environment is represented by a grid, in which cells with an obstacle have their potential value set to 1 whereas cells that contain the target have their potential value set to 0. A relaxation algorithm is then employed to calculate the harmonic potential among the obstacles and the target. These two techniques have been applied in robot soccer environment to develop game strategies. Results obtained show that both techniques present better results when compared to the standard strategy or the FIRA Simulator. Further, a comparison of these techniques is presented for showing the advantages and disadvantages existing in each one of them.
Hidden decay of impact after education for self-management of chronic illnesses: hypotheses

People with chronic illnesses can benefit from self-management education. However, those benefits are said to decay over time (there is some evidence that this ‘decay of impact’ does occur), and the reinforcements used to prevent that decay appear to be ineffective. We hypothesize that the reinforcements appear to be ineffective because decay of impact occurs only in a subgroup of these programs' participants, so any benefits of reinforcements in that subgroup are concealed by whole-group summary statistics. We also hypothesize that reinforcements can benefit those who need them – those who would otherwise have decay. One approach to testing these hypotheses requires analysis of individual-level data, which is uncommon in this field. Some useful data could come from studies that have already been completed, but the strongest evidence will require prospectively designed tests in future trials. If the hypotheses are false, then time and resources spent on reinforcements can be saved or redirected. If the hypotheses are true, then reinforcements can be implemented with less waste and they can be made more effective. These programs can also be improved to better fit their users’ needs, and there can be a new basis for evaluating the programs’ effectiveness.
Prediction of Law Enforcement Training Performance and Dysfunctional Job Performance With General Mental Ability, Personality, and Life History Variables

Two studies were conducted on personnel in the field of law enforcement. Study 1 examined the predictability of law enforcement candidates who failed to complete either academy or field training versus a matched-case control sample who passed training. Study 2 examined the predictability of lawenforcement officers who were formally disciplined for inappropriate behavior on the job versus a matched-case control sample who were not disciplined. General mental ability, personality, and life history variables served as the predictors of these criteria. The predictive accuracy of a specially constructed life history veracity index (an internal validity scale) was also examined. The results revealed that both criteria were predictable, but with differential accuracy across the predictor types. These findings are discussed in the context of recent research on the selection of law enforcement personnel, the major constructs assessed in the study, and issues associated with longitudinal validational research.
Middle Class Fractions, Childcare and the ‘Relational’ and ‘Normative’ Aspects of Class Practices

The emphasis in class research remains on the structural aspects of class, class processes are neglected. This paper focuses upon some relational and normative aspects of class through an examination of social divisions produced and constructed within middle class families' choices of childcare. Working with data from two contrasting settings in London (Battersea and Stoke Newington) three issues are addressed in the paper; the extent to which childcare arrangements both substantively and structurally position children differently within long term educational careers; the ways in which the use of choice in a market system of child care and education, works to produce patterns of social closure that quietly discriminate via the collectivist criterion of class and racial membership; and the ways in which child care choices also point-up and perpetuate subtle distinctions and tensions of values and lifestyle within the middle class, between class factions. Concepts drawn from the work of Bourdieu are deployed throughout.
Outage Region Characterization for Beamforming in MISO Interference Networks with Imperfect CSI

We consider an interference network with independent links, whose multi-antenna transmitters have access to an imperfect analog estimate of their local channels. Assuming that the receivers treat the interference as noise, we define the outage rate region as the set of rate-tuples that are achievable with a given probability and we characterize the boundary of the region for transmit beamforming. Our study shows that the Pareto-optimal beamforming vectors judiciously balance the desired signal power and the interference power based on the quality of the estimated channel state. Our analysis further reveals that, in contrast to the well-known results by Jorswieck , for the perfect channel side-information case, transmission at full power is not necessarily Pareto-optimal.
Genotypic analysis of hepatitis C virus in American patients

We examined hepatitis C virus genotypes in 98 American patients with chronic hepatitis C virus infection by means of two methods; restriction fragment length polymorphism analysis and line probe assay, which is based on type‐specific sequence variations in the 5′ untranslated region. Type 1 was present in 73 patients (74%), type 2 in 15 (15%), type 3 in 6 (6%) and type 4 in 1 (1%). Line probe assay further subdivided type 1 into 1a (n = 35) and type 1b (n = 37) and type 2 into type 2a (n = 6) and 2b (n = 9). Two patients (2%) had both restriction fragment length polymorphism and line probe assay evidence of dual infection (with types 1 and type 2) while another case had both type 1a and 1b by line probe assay. One patient was untypable by either technique. There was no correlation between infecting genotype and presumed cause, serum indexes of necroinflammatory activity, or age or sex of the patients studied or known duration of infection. Patients with type 2 hepatitis C virus had more severe liver disease histologically (p = 0.0027) compared with other genotypes but, paradoxically, had significantly lower levels of circulating hepatitis C virus RNA (12.1 ± 12.8 × 105 genome equivalents/ml) than other types (36.4 ± 44.8 × 105 genome equivalents/ml, p < 0.001). Response to interferon was less likely to be sustained in patients infected with type 1 than in those infected with other types (7% vs. 40%, p < 0.05). Thus hepatitis C virus genotype may have some influence on the clinical pattern of hepatitis, particularly with regard to the disease severity and response to interferon. The restriction fragment length polymorphism and line probe assays produced concordant results in 97 of 98 cases; however, whereas restriction fragment length polymorphism provides a relatively easy and reliable method for genotyping hepatitis C virus, the line probe assay is more rapid, uses standardized reagents, does not require radioisotopes and has the advantage of distinguishing the subtypes of genotype 1 and 2.
AVALIAÇÃO DE UM INSTRUMENTO DE MENSURAÇÃO DE MORBIDADE PSÍQUICA: ESTUDO DE VALIDAÇÃO DO SELF-REPORTING QUESTIONNAIRE (SRQ-20)

O Self-Reporting Questionnaire (SRQ-20), desenvolvido pela Organizacao Mundial de Saude, tem sido utilizado para mensuracao de nivel de suspeicao de transtornos mentais em estudos brasileiros, especialmente em grupos de trabalhadores. O objetivo deste estudo foi avaliar o desempenho do SRQ-20, com base em indicadores de validade (sensibilidade, especificidade, taxa de classificacao incorreta e valores preditivos), e determinar o melhor ponto de corte para classificacao dos transtornos mentais comuns na populacao estudada. O estudo incluiu 91 individuos selecionados aleatoriamente de um estudo de corte transversal realizado com populacao residente em areas urbanas de Feira de Santana (BA). Entrevistas clinicas, realizadas por psicologas, utilizando o Revised Clinical Interview Schedule (CIS-R), foi adotada como padrao-ouro. Na avaliacao do desempenho do SRQ-20 foram estimados indicadores de validade (sensibilidade e especificidade). A curva Receiver Operator Characteristic Curve (ROC) foi utilizada para determinar o melhor ponto de corte para classificacao de suspeitos/nao suspeitos. O ponto de corte de melhor desempenho foi de 6/7 para a populacao investigada, revelando desempenho razoavel com area sob a curva de 0,789. Os resultados indicam que o SRQ-20 possui caracteristica discriminante regular.
SIGBED Review Vol. 8, Num. 3, September 2011

In this paper we discuss the problem of tracing event chains (distributed transactions) while extracting an end-to-end timing model from an existing industrial component model, the Rubus Component Model (RCM). RCM supports component-based development of distributed embedded and real-time systems. The purpose of extracting an end-to-end timing model is to perform the holistic response-time analysis of component-based distributed realtime applications modeled with RCM. We present a solution for RCM by introducing special purpose generic components to it. We believe that the solution is also suitable for other component models that use a pipe-and-filter style for component interconnection. Keywords-holistic response-time analysis; distributed realtime systems; timing model; model-based development.
Arginylated Calreticulin at Plasma Membrane Increases Susceptibility of Cells to Apoptosis*

Background: Calreticulin retrotranslocated from the endoplasmic reticulum to the cytoplasm is post-translationally arginylated associates to stress granules following stress that decrease Ca2+. Results: Arginylated calreticulin reaches the plasma membrane as a response to stress. Conclusion: Arginylation confers to calreticulin a function as one of the preapoptotic signals of the cells. Significance: Arginylated calreticulin is a novel factor involved in stress-induced apoptosis. Post-translational modifications of proteins are important for the regulation of cell fate and functions; one of these post-translational modifications is arginylation. We have previously established that calreticulin (CRT), an endoplasmic reticulum resident, is also one of the arginylated substrates found in the cytoplasm. In the present study, we describe that arginylated CRT (R-CRT) binds to the cell membrane and identified its role as a preapoptotic signal. We also show that cells lacking arginyl-tRNA protein transferase are less susceptible to apoptosis than wild type cells. Under these conditions R-CRT is present on the cell membrane but at early stages is differently localized in stress granules. Moreover, cells induced to undergo apoptosis by arsenite show increased R-CRT on their cell surface. Exogenously applied R-CRT binds to the cell membrane and is able to both increase the number of cells undergoing apoptosis in wild type cells and overcome apoptosis resistance in cells lacking arginyl-tRNA protein transferase that express R-CRT on the cell surface. Thus, these results demonstrate the importance of surface R-CRT in the apoptotic response of cells, implying that post-translational arginylation of CRT can regulate its intracellular localization, cell function, and survival.
More than Just Biological Sex Differences

The influence of gender on travelers’ information search behavior continues to attract the attention of researchers. However, most scholars have studied gender differences from a biological perspective, treating gender as a unitary theoretical concept. This article challenges such an approach and argues for a more differentiated perspective to the study of gender differences in information search behavior. It approaches gender differences from a psychological perspective and proposes that the travelers’ gender identity (masculinity and femininity) is a determinant of their search behavior. The gender schema theory and the selectivity theory inform the model of the study. Five hypotheses are developed and are tested using responses collected from 568 tourists. Results from the structural equation modeling analysis indicate support for all hypotheses, confirming that gender identity is a good determinant of travelers’ search behavior. Travelers displaying high femininity traits were found to engage in more internal as well as external information search. Respondents with high masculinity traits relied less on both internal and external search for information. The theoretical and managerial implications, as well as the limitations of the study are discussed. The study also provides some directions for future research.
Citing Discourses: Making Sense of Homophobia and Heteronormativity at Dynamic High School

In this article, I draw on poststructuralist work on "citationality" to elucidate an urban high school's student culture and intervention efforts with regard to LGBQ issues. I contend that the language, ideas and practices of LGBQ issues and awareness among students and staff "cite" or draw on broader (and often competing) discourses of normalcy, sexuality, and/or "good teaching. " I discuss how the citational process makes it difficult to bring about change, as well as the possibilities for bringing about change. The significance of this article is the way it explicates the discourses used to articulate and describe LGBQ people, issues, and intervention efforts; and how these discourses may hinder efforts to create LGBQ support and awareness in schools.
Design metrics for blind ADC-based wireline receivers

ADC-based receivers use an ADC in the front end to convert the incoming signal to digital where significant equalization can be done in digital domain. These receivers can be classified as phase-tracking and blind architectures. In the former, the VCO phase is controlled through a feedback loop so as to sample the received data in the middle of the data eye. In the latter, the received signal is sampled with a blind clock, i.e. not in a loop, and the data at the center is obtained by data processing techniques such as data interpolation and extrapolation. This paper compares the two architectures in terms of their design complexity and cost, and derives equations that relate the required ADC resolution to channel loss and to the characteristics of the FFE/DFE that follow the ADC.
Torque Ripple Reduction in an Axial Flux High Temperature Superconducting Motor

The design, construction, and operation of superconducting rotatory machines in an axial flux configuration are strongly dependent on the ability to reduce torque ripple. A new concept is presented in order to maximize the output power optimizing the magnetic flux density within the air gap of a three-phase fully superconducting induction motor. The machine is designed on a basis of bilateral stators distributed around a central rotor. The optimal distribution of magnetic flux and the minimization of torque ripple are resulting from an adequate distribution of motor phases, number of rotor bars, and choice of air-gap thickness. The magnitude of magnetic flux in the air gap is obtained by means of finite-element analysis, and some derived parameters are compared to experimental results. Then, the impact of the design on torque magnitude and torque ripple is discussed.
A systematic review on comparing 2 common models for management of warfarin therapy; pharmacist‐led service versus usual medical care

Despite a growing body of literature supporting the potential benefit of pharmacist‐managed warfarin therapy (PMWT), comprehensive reviews regarding this topic are still lacking. A systematic search of literature was done in Pubmed/Medline, Scopus, Google Scholar, and Cochrane Library from database inception to January 2014. Studies comparing PMWT with usual medical care (UMC) regarding the control of anticoagulation, bleeding and thromboembolic events, mortality, hospitalization, emergency department visit, cost, patients' satisfaction, and quality of life were included. Of 758 potential articles identified, 24 studies (4 randomized controlled trials [RCT] and 20 non‐RCT studies) with a population of 11 607 were included. Among non‐RCT studies, the percentage of time in the therapeutic range (72.1% vs 56.7%; P = .013), major bleeding events (0.6% vs 1.7%, P < .001), thromboembolic events (0.6% vs 2.9%; P < .001), hospitalization (3% vs 10%; P < .001), emergency department visits (7.9% vs 23.9%; P < .0001) significantly favored PMWT. The study supported PMWT regarding cost saving and patient satisfaction. The results showed that the PMWT model is superior to UMC in managing warfarin therapy based on observational studies. As well, it is comparable to UMC based on RCT studies.
A Targeted Inhibition of DNA-Dependent Protein Kinase Sensitizes Breast Cancer Cells Following Ionizing Radiation

A major mechanism by which cancer cells become resistant to ionizing radiation (IR) and chemotherapy drugs is by enhanced DNA repair of the lesions; therefore, through inhibition of DNA repair pathways that tumor cells rely on to escape chemotherapy, we expect to increase the killing of cancer cells and reduce drug resistance. DNA-dependent protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase essential for DNA repair as well as sensing and transmitting a damage signal to downstream targets leading to cell cycle arrest. We used a peptide cotherapy strategy to see whether a targeted inhibition of DNA-PK activity sensitizes breast cancer cells in response to IR or chemotherapy drug. A synthesized peptide representing the C terminus of Ku80 (HNI-38) selectively targeted and disrupted interaction between Ku complex and the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) as well as the DNA binding activity of Ku that led to the inhibition of DNA-PK activity and reduction in double-stranded DNA break (dsb) repair activity. Furthermore, a peptide-based inhibitor with target sequence effectively inhibited the growth of breast cancer cells only in the presence of DNA damage, suggesting that the target peptide sensitizes cancer cells through blocking dsb DNA repair activity. Together, this study not only validates the involvement of the C terminus of Ku80 in Ku's DNA termini binding and interaction with DNA-PKcs, but also a supports physiological role for DNA-PK in IR or chemotherapy drug resistance of cancer cells.
Stability and Change in Parents' Expectations about Mainstreaming

Families of children in mainstreamed environments have varying expectations associated with these integrated placements. Although previous studies have described some of these expectations in a retrospective fashion, no study has assessed expectations prior to the initiation of mainstreaming or documented the extent to which such expectations change during the course of a mainstreaming experience. This article describes the expectations of families of both handicapped and nonhandicapped children prior to the introduction of handicapped children into a day care center that had previously served only nonhandicapped youngsters. A follow-up assessment was conducted after 9 months of mainstreaming. Stability and change in parents' expectations are described and the implication of the findings for planning individualized family services are discussed.
The Evolution of Networks and the Resilience of Interorganizational Relationships after Disaster

This study uses social capital and evolutionary theory to examine organizational resilience in terms of interorganizational networks of disaster-struck organizations following Hurricane Katrina. Approaching post-disaster organizational resilience using social network analysis highlights the way pre-disaster relationships and networking patterns play a vital role in post-disaster rebuilding. Data support the idea of structural inertia, suggesting that disaster is an event that further strengthens pre-existing networks and is not a time when organizations might benefit from forging new networks in seeking support and fueling survival. Implications suggest that the social capital accrued through long-standing partnerships and efficient pre-disaster networking through building communities of practice significantly impact post-disaster resilience.
PRESERVING PRIVACY IN DATA MINING USING SEMMA METHODOLOGY

The huge amount of data available means that it is possible to learn a lot of information about individuals from public data. Here, this open data need to be sheltered from unlawful contact. The privacy-preserving data mining (PPDM) has thus become a significant subject in most recent years. Generally privacy means "keep information about person from being available to others" but, the real worry is that their information not be mishandle. The data mining techniques enable users to extract the hidden patterns which may lead to leakage of sensitive data. So the main concern is to secure the data mining result with the help of PPDM. This paper provides a framework to preserve privacy in data mining results by manipulating SEMMA analysis cycle.