Miracle-dz/UniFAR-FTUs huggingface dataset:
Lossy 3D Mesh Compression using Loop Scheme

Subdivision surfaces are finding their way into many Computer Aided Design and Animation packages. Popular choices include Loop, Catmull-Clark, Doo-Sabin etc. Subdivision surfaces have many design advantages over traditional use of Non Uniform Rational B-Splines (NURBs). 3D mesh compression has become necessary for transferring and browsing 3D objects over the internet. MPEG-4 has included encoding capability for 3D polygonal meshes. Level of details (LOD), progressive transmission, and 3D streaming are possible applications of the mesh compression. Our paper looks at developing one such method for Loop surfaces. Our method can handle any arbitrarily topological non-boundary/boundary objects of any genus. The paper shows the process as well as some results, which are promising and therefore can be used as a lossy compression scheme and a surface reconstruction method.
Influence of atmospheric transport on the inter‐annual variation of the CO2 seasonal cycle downward zero‐crossing

Using a 3‐dimensional atmospheric transport model driven by the ECMWF winds and the non‐interannually varying seasonal biospheric flux from the CASA global ecosystem model, we show that a significant change in the downward‐zero crossing day (DZCD) of the atmospheric CO2 seasonal cycle in the Northern Hemisphere above 30°N latitude can be obtained by year‐to‐year changes in the atmospheric transport alone. The transport model is able to reproduce both the trend and standard deviation of DZCD observed at Pt. Barrow. With only atmospheric transport changing from year to year, eastern North Atlantic, Europe, southern Eurasia, southeastern United States and western North America show DZCD starting earlier by 5–10 days after 21 years of model integration. If DZCD obtained from CO2 monitoring stations is going to be used as a proxy for determining the growing season length, then it is important to take into account of that portion caused by the atmospheric transport.
Mechanisms of Growth Inhibition in Human Papillomavirus Positive and Negative Cervical Cancer Cells by the Chloromethyl Ketone Protease Inhibitor, Succinyl-Alanine-Alanine-Proline-Phenylalanine Chloromethyl Ketone

The chymotrypsin-like serine protease inhibitor, succinyl-alanine-alanine-proline-phenylalanine chloromethyl ketone (AAPFCMK), has been shown to have anticarcinogenic activity in a number of model systems and to be relatively selective for a nuclear protease. This inhibitor also has substantial effects on growth of tumorigenic human papillomavirus (HPV)-infected keratinocytes in organotypic raft cultures. Here, we examined the effects of AAPFCMK on cell growth, cell-cycle kinetics, apoptosis induction, and DNA synthesis in two human cervical carcinoma cell lines: SiHa cells, which have integrated high-risk HPV-16; and C33a cells, which do not contain HPV DNA. AAPFCMK inhibited growth of both cell lines in a time- and dose-dependent manner. Apoptosis studies showed no significant difference in drug-treated versus vehicle-treated cells in the C33a cell line. However, a significant dose-dependent increase in apoptosis occurred at a late time point in SiHa cells. Cell-cycle progression and DNA synthesis assays showed that the cellular mechanisms of growth inhibition by AAPFCMK differ between the HPV16-positive and HPV-negative tumorigenic cell lines. Drug-treated C33a cells showed a significant accumulation of cells in the G2 phase of the cell cycle. In SiHa cells, growth inhibition produced by AAPFCMK seemed to result from a global arrest of the cell cycle. Although the molecular mechanisms involved in AAPFCMK-induced growth inhibition are distinct between the two tumorigenic cell lines, such differences may ultimately prove to have therapeutic utility. Novel therapies for treating established HPV infections are needed, because HPV is a causative agent in the development of multiple types of cancer.
Impact of transient increases in atmospheric CO2 on the accumulation and mass balance of the Antarctic ice sheet

The response of the Antarctic ice sheet to climate change over the next 500 years is calculated using the output of a transient-coupled ocean-atmosphere simulation assuming the atmospheric CO2 value increases up to three times present levels. The main effects on the ice sheet on this time-scale include increasing rates of accumulation, minimal surface melting, and basal melting of ice shelves. A semi-Lagrangian transport scheme for moisture was used to improve the model’s ability to represent realistic rates of accumulation under present-day conditions, and thereby increase confidence in the anomalies calculated under a warmer climate. The response of the Antarctic ice sheet to the warming is increased accumulation inland, offset by loss from basal melting from the floating ice, and increased ice flow near the grounding line. The preliminary results of this study show that the change to the ice-sheet balance for the transient-coupled model forcing amounted to a minimal sea-level contribution in the next century, but a net positive sea-level rise of 0.21 m by 500 years. This new result supercedes earlier results that showed the Antarctic ice sheet made a net negative contribution to sea-level rise over the next century. However, the amplitude of the sea-level rise is still dominated In the much larger contributions expected from thermal expansion of the ocean of 0.25 m for 100 years and 1.00 m for 500 years.
Overcoming the influence of chronic pain on older patients' difficulty with recommended self-management activities.

PURPOSE Many older patients with common chronic conditions also experience chronic pain. We examined how chronic pain affects patients' difficulty with recommended self-management activities and the potential intervening role of self-efficacy (the level of confidence in one's own ability to perform a specific task). DESIGN AND METHODS We obtained data from a cross-sectional nationwide survey of older patients, primarily older men, with chronic health conditions (N = 543). We defined chronic pain as pain present most of the time for 6 months or more during the past year. We assessed ability to follow self-management recommendations by asking respondents to rate their level of difficulty in performing three commonly recommended activities as suggested by their doctor. RESULTS More than 60% of survey respondents reported chronic pain. Chronic pain was significantly associated with difficulty exercising regularly (odds ratio [OR] = 1.57, 95% confidence interval [CI] = 1.04-2.37) and taking prescribed medications (OR = 3.08, 95% CI = 1.10-8.59) but not with following a recommended eating plan (OR = 1.16, 95% CI = 0.76-1.76). However, when we took self-efficacy into account, chronic pain was no longer significantly associated with either exercise or taking medications. IMPLICATIONS Chronic pain is a prevalent condition among older patients and is associated with greater reported difficulty performing certain essential self-management activities. Self-efficacy, however, plays an important intervening role. Specifically, higher self-efficacy negated or reduced the association between chronic pain and reported difficulty exercising and taking medications. Promoting self-efficacy among older adults with multiple chronic health problems is a promising strategy to improve their ability to follow self-management recommendations.
A dominant mechanism for thin film power capacitors going high or self-destructing

Thin film capacitors typically degrade in use by exhibiting much increased dissipation factors and nominal capacitance values that fall off steeply with frequency. The cause of the increased loss is poorly explained in the literature and is often inferred to be probably due to changes in the properties of the dielectric film. However, it can be shown that the increase in losses can almost entirely be attributed to increased losses in the metal film due to increased path lengths brought on principally by corrosion. Further, the modification of the path lengths can result in localized heating and sporadic fusing of vestigial links during operation, greatly increasing the risk of catastrophic failure. Measurement and teardown inspection of degraded capacitors provide strong support for theoretical modeling involving the critical role of corrosion in capacitor degradation and failure.
Probabilistic Lane Tracking in Difficult Road Scenarios Using Stereovision

Accurate and robust lane results are of great significance in any driving-assistance system. To achieve robustness and accuracy in difficult scenarios, probabilistic estimation techniques are needed to compensate for the errors in the detection of lane-delimiting features. This paper presents a solution for lane estimation in difficult scenarios based on the particle-filtering framework. The solution employs a novel technique for pitch detection based on the fusion of two stereovision-based cues, a novel method for particle measurement and weighing using multiple lane-delimiting cues extracted by grayscale and stereo data processing, and a novel method for deciding upon the validity of the lane-estimation results. Initialization samples are used for uniform handling of the road discontinuities, eliminating the need for explicit track initialization. The resulting solution has proven to be a reliable and fast lane detector for difficult scenarios.
Meta-classifiers in acoustic and linguistic feature fusion-based affect recognition

We suggest a novel approach to affect recognition based on acoustic and linguistic analysis of spoken utterances. In order to achieve maximum discrimination power within robust integration of these information sources, a fusion on the feature level is introduced. Considering classification, we use meta-classifiers, such as StackingC and Boosting, for a stabilized performance, and a combination of classifiers within ensembles. Extensive comparisons of diverse base-classifiers, including support vector machines, neural networks, stochastic models, and decision trees, are fulfilled. 381 acoustic features are extracted and their relevance is calculated by a sequential forward floating search in comparison to reduction by principal component analysis. Several variants for linguistic feature calculation are described and ranked, including bunch-of-words, n-grams, salience, and mutual information. Furthermore, reduction by stopping and stemming or filter-based selection methods is evaluated, reducing 2,334 linguistic features. Seven discrete emotions described in the MPEG-4 standard are recognized within an existing recognition engine. The presented results are based on two large databases of 4,336 acted and real emotion samples from movies, chat and car interaction dialogues. A significant gain and an outstanding overall performance are observed by this novel fusion and use of ensembles.
Applying intrusion detection systems to wireless sensor networks

The research of Intrusion Detection Systems (IDS) is a mature area in wired networks, and has also attracted many attentions in wireless ad hoc networks recently. Nevertheless, there is no previous work reported in the literature about IDS architectures in wireless sensor networks. In this paper, we discuss the general guidelines for applying IDS to static sensor networks, and introduce a novel technique to optimally watch over the communications of the sensors’ neighborhood on certain scenarios.
Circulation around islands and ridges

The circulation in an ocean basin containing an island is studied under nearly geostrophic, beta plane dynamics. The model is a fluid of uniform density driven by wind forcing or sources and sinks of mass at the upper boundary of the flow. The circulation is studied analytically, numerically, as well as in the laboratory through the device of the “sliced cylinder” model for the ocean circulation. Of particular interest is the estimate of the transport between the island and the oceanic basin’s boundary. The model is conceived as relevant to both the wind-driven circulation as well as the circulation of abyssal waters around deep topographic features such as mid-ocean ridge segments. Godfrey’s Island Rule for the transport is rederived in general form and the validity of the original approximation of Godfrey (1989) is examined in a variety of circumstances. In particular, the role of dissipative boundary layers and inertial effects such as vortex shedding are scrutinized to determine their role in determining the net transport around the island. Linear theory in many cases predicts a recirculation on the eastern side of the island, provided the meridional extent of the island is large enough. The existence of the recirculation, containing trapped fluid, is confirmed in both laboratory and numerical experiments and the evolution of the structure of the recirculation is examined as a function of the boundary layer Reynolds number. In both the laboratory and numerical studies, the recirculation predicted by linear theory is joined and then superseded by an inertial recirculation springing from boundary layer separation as the Reynolds number increases past a critical value. Even in the linear limit it is shown that the recirculation region, which is closed in quasigeostrophic theory, is subject to a small leak due to planetary geostrophic effects, which prediction is confirmed in the laboratory. The original island rule of Godfrey yields an estimate of the transport which is surprisingly robust and generally within 75% of the values measured in our numerical experiments. Agreement is moderately good when island western boundary layer transport is used as a basis for comparison. Several cases are discussed, however, in which the assumptions made by Godfrey are violated. One occurs when the frictional boundary layers of the island and the basin boundary overlap. We derive a threshold width for the gap for the case where the island is close to a northern or southern boundary of the basin and show how the transport is increasingly blocked as the gap is reduced. A second case occurs when the island is thin and zonally elongated so that the dissipative effects on the northern and southern boundaries of the island become important. Here the vorticity balance assumed in the simple Island Rule is fundamentally altered, and we extend the Island Rule to account for the new dissipation.
Impact of Pharmacokinetically-guided Dose Adaptation of 5-Fluorouracil : Results from a Multicentric Randomized Trial in Patients with Locally Advanced Head and Neck Carcinomas ’

A significant link between 5-fluorouradil (SFU) plasma concentration and its therapeutic activity has been demonstrated in colon and head and neck cancer patients for SFU used as a continuous infusion. Dose adjustment based on pharmacokinetic follow-up has been proposed to decrease hematological and digestive toxidties, but the dinical impact of this approach has not yet been demonstrated. A randomized madticentric study was conducted to evaluate the dinical Interest of SFU dose adaptation guided by pharmacokineties. One hundred twenty-two head and neck cancer patients were randomly assigned to receive induction chemotherapy with cisplatin (100 thy 1) and SFU (96-h continuous infusion), either at standard dose (St-arm; 4 g/m2) or at a dose adjusted according to the SFU area under the curve (AUC0 ; PK-arm). In total, 106 patients were evaluable for tOXiCity and response. hi the PK-arm (n = 49), SFU doses and area under the curve were significanfly reduced during cycle 2 and cycle 3 (P < 0.001) as compared with the St-arm (n = 57). Grade 3-4 neutropenia and thrombopenia were significantly more frequent in the St-arm as compared with the PK-arm (17.5% versus 7.6%, respectively; P = 0.013). No grade 3-4 mucositis occurred in the PK-arm, whereas 5.1% was observed in the St-arm (P < 0.01). The objective response rate was comparable in the two treatment arms: 77.2% in the St-arm versus 81.7% in the Received 3/13/98; revised 5/27/98; accepted 6/8/98. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. I Supported by Produits Roche, the French “F#{233}d#{233}ration N ale des Centres de Lutte Contre Ic Cancer,” and the “Ligue Nationale contre Ic Cancer, comit#{233}de la Meurthe et Moselle. ” These data were presented in part at the 1997 meeting of the American Society of Clinical Oncology. 2 To whom requests for reprints should be addressed, at Centre Ren#{233} Gauducheau, Boulevard Jacques Monod, 44805 Saint Herblain CedexFrance. Phone: 33-2-40-67-99-60. Fax: 33-2-40-67-97-05. Email: r-fety@gauducheau-nantes.fnclcc. fr. PK-arm. The present study is the first to demonstrate, in a randomized design, the dinical interest of an individual SFU dose adaptation based on pharmacokinetic survey, in terms of therapeutic index improvement.
Systematic reviews of trials and other studies.

or executive summary Background information ‘The need for the report should be justified by clearly describing the problem for which evidence of effectiveness is required, and describing the needs of the health care professionals and consumers who are to benefit from the report. ’ Hypotheses tested in the review Review methods ‘The methods used should be described in sections for search strategy, inclusion criteria, assessments of relevance and validity of primary studies, data extraction, data synthesis, and investigations of differences between studies. ’ Details of studies included in the review ‘. details relating to the patient groups included, mode of intervention and the outcomes assessed in each study. Details of study results, study design and other aspects of study quality and validity should also be given. Sufficient information should be provided to allow replication of the analysis. ’ Details of studies excluded from the review Given reason for exclusion. Results of the review ‘The estimates of efficacy from each of the studies should be given, together with the pooled effect if this has been calculated. All results should be expressed together with CIs. The table or diagram should indicate the relative weight that each study is given in the analysis. The test for heterogeneity of study results should be given if appropriate and all investigations of the differences between the studies should be report- ed in full. As well as reporting the results in relative terms the impact of the results in absolute terms [such as absolute risk reduction (ARR) and number needed to treat (NNT) (see pages 109–10)] should be given. This permits the clinical significance and possible impact of the intervention to be assessed. ’ Analysis of the robustness of the results ‘Sensitivity analyses should be performed and documented to investigate the robustness of the results where there is missing data, uncertainty about study inclusion, or where there are large studies which dominate the data synthesis. ’ (see pages 209–10 for more details on sensitivity analysis).
Influence of Dry Clutch and ICE Transmission Integration on the Thermal Load of a PM-Based Integrated Starter-Generator

Aiming to increase vehicle performance, the thermal influence of the vehicle integration on the thermal load on an integrated starter-generator (ISG) is discussed. In the investigated case, the vehicle integration concerns a dry clutch module and an internal combustion engine (ICE) attached. An experimentally validated numerical thermal model is developed as a tool for the analysis. This model includes the additional heat sources given by the ICE and the dry friction clutch. The influence on three temperatures considered most critical, those of the bearings, the permanent magnets, and the stator winding, is studied.
Regression Analysis of Tourist Photographic Activity Using Geo-tagged Photos andGPS Trajectory

Nowadays, many photos are posted on social photo sharing web sites (e.g. Flickr, Instagram). The number of the shared geo tag photos in a certain attraction does not correlate to the number of visitors because the photographic activity is influenced by multiple factors. The estimation of the number of tourists in a certain attraction from the geo tagged photos is useful for marketing and tourism policy making. In this paper, from the viewpoint of tourism information, we propose a photographic activity model to estimate the number of tourists in the attraction and examine the model by using the regression analysis. We analyze the dataset consists of GPS trajectory and the photographic history of foreign tourists who traveled in Kyoto area in Japan. As the results, we show that the proposed photographic activity model indicates high goodness of fit and correlation to the dataset.
Neural Mechanisms of Time-Based Prospective Memory: Evidence for Transient Monitoring

In daily life, we often need to remember to perform an action after, or at, a specific period of time (e.g., take pizza out of oven in 15 minutes). Surprisingly, little is known about the neural mechanisms that support this form of memory, termed time-based prospective memory (PM). Here we pioneer an fMRI paradigm that enables examination of both sustained and transient processes engaged during time-based PM. Participants were scanned while performing a demanding on-going task (n-back working memory), with and without an additional time-based PM demand. During the PM condition participants could access a hidden clock with a specific button-press response, while in the control condition, pseudo-clocks randomly appeared and were removed via the same response. Analyses tested for sustained activation associated with the PM condition, and also transient activation associated with clock-checks and the PM target response. Contrary to prior findings with event-based PM (i.e., remembering to perform a future action when a specific event occurs), no sustained PM-related activity was observed in anterior prefrontal cortex (aPFC) or elsewhere in the brain; instead, transient clock-related activity was observed in this region. Critically, the activation was anticipatory, increasing before clock-check responses. Anticipatory activity prior to the PM target response was weaker in aPFC, but strong in pre-Supplementary Motor Area (pre-SMA; relative to clock-check responses), suggesting a functional double dissociation related to volitional decision-making. Together, the results suggest that aPFC-activity dynamics during time-based PM reflect a distinct transient monitoring process, enabling integration of the PM intention with current temporal information to facilitate scheduling of upcoming PM-related actions.
Competition among zinc, manganese, and cadmium uptake in the freshwater alga Scenedesmus vacuolatus

In the present study, Zn and Mn competition with Cd uptake was investigated in the freshwater alga Scenedesmus vacuolatus. Scenedesmus vacuolatus was exposed to experimental media with Cd and either Zn or Mn in short‐term experiments; long‐term experiments were undertaken to investigate the effect of growth on Cd accumulation. Cadmium accumulation in S. vacuolatus could be detected at very low exposure concentrations (free Cd2+, 2 × 10−14 to 1 × 10−11 M), and uptake was proportional to the free‐Cd2+ concentration. Zinc was an effective competitive inhibitor of Cd uptake when the Zn2+ to Cd2+ ratio was greater than 14 in the exposure medium, whereas Mn competed with Cd for uptake above a Mn2+ to Cd2+ ratio of greater than 10,000. Binding constants for Cd and Zn affinity to the transport sites were determined (KZn and KCd). Values for KZn were slightly higher (log K = 9.4–9.8) than values for KCd (log K = 8.9–9.8). In contrast, Cd seemed not to compete with the Mn‐binding sites for uptake over the Mn concentration range from 1 × 10−10 to 1 × 10−8 M. Determined values for the binding constants of Zn and Cd show that a simple model can be applied to predict Cd uptake at known Zn and Cd concentrations. The environmental implications of these results are discussed with respect to potential Cd toxicity for aquatic organisms.