Miracle-dz/UniFAR-FTUs huggingface dataset:
Changes in Cerebral Cortex and Limbic Brain Functions after Short-Term Paroxetine Treatment in Panic Disorder: An [18F]FDG-PET Pilot Study

Objective Panic disorder (PD) is a common and often chronic psychiatric illness, and serotonin-specific reuptake inhibitors (SSRIs) are the drugs of choice for the treatment of PD. Previous studies suggested the cerebral cortex and limbic brain structures played a major role in the development of PD, but the therapeutic effect of SSRIs on specific brain structures remains unclear in PD. We examined the changes in PD patients' glucose metabolism using the [18F] Fluorodeoxy-glucose-positron emission tomography (FDG-PET) before and after 12 weeks of paroxetine treatment. Methods We assessed the brain glucose metabolism of 5 PD patients, using the [18F]FDG-PET, and treated them with paroxetine (12.5-37.5 mg/day) for 12 weeks. Then, we compared before and after treatment PET images of the patients, using voxel-based statistical analysis and a post hoc regions of interest analysis. Furthermore, we measured the patients' clinical variables, including information from the Panic Disorder Severity Scale (PDSS), Clinical Global Impression for Severity (CGI-S), and Hamilton Anxiety Rating Scale (HAMA). Results After 12 weeks of paroxetine treatment, the patients showed significant clinical improvement in terms of PDSS, CGI-S and HAMA scores (12.8±1.8 vs. 3.8±2.3, 4.6±0.5 vs. 2.0±1.4, and 15.2±4.0 vs. 5.0±1.2, respectively; all p values<0.05). After treatment, patients' glucose metabolism increased significantly in global brain areas: the right precentral gyrus, right middle frontal gyrus, right amygdala, right caudate body, right putamen, left middle frontal gyrus, left precentral gyrus, left insula, left parahippocampal gyrus, and left inferior frontal gyrus (All areas were significant at uncorrected p<0.001 and cluster level corrected p<0.05). Conclusion In these PD patients, cerebral cortex and limbic brain functions changed after short-term treatment with paroxetine. The therapeutic action of paroxetine may be related to altered glucose metabolism at both the cerebral cortex and limbic brain areas.
Correlative Fluorescence and Scanning Electron Microscopy of Labelled Core Fucosylated Glycans Using Cryosections Mounted on Carbon-Patterned Glass Slides

The aim of the study is co-localization of N-glycans with fucose attached to N-acetylglucosamine in α1,3 linkage, that belong to immunogenic carbohydrate epitopes in humans, and N-glycans with α1,6-core fucose typical for mammalian type of N-linked glycosylation. Both glycan epitopes were labelled in cryosections of salivary glands isolated from the tick Ixodes ricinus. Salivary glands secrete during feeding many bioactive molecules and influence both successful feeding and transmission of tick-borne pathogens. For accurate and reliable localization of labelled glycans in both fluorescence and scanning electron microscopes, we used carbon imprints of finder or indexed EM grids on glass slides. We discuss if the topographical images can provide information about labelled structures, the working setting of the field-emission scanning electron microscope and the influence of the detector selection (a below-the-lens Autrata improved YAG detector of back-scattered electrons; in-lens and conventional Everhart-Thornley detectors of secondary electrons) on the imaging of gold nanoparticles, quantum dots and osmium-stained membranes.
Developing a tool to measure pharmacoeconomic outcomes of post-surgical pain management interventions

Abstract Background Financial pressures have limited the ability of providers to use medication that may improve clinical outcomes and patient satisfaction. New interventions are often fraught with resistance from individual cost centers. A value realization tool (VRT) is essential for separate cost centers to communicate and comprehend the overall financial and clinical implications of post-surgical pain management medication interventions (PSMI). The goal was to describe development of a VRT. Methods An evaluation of common in-patient PSMI approaches, impacts, and costs was performed. A multidisciplinary task force guided development of the VRT to ensure appropriate representation and relevance to clinical practice. The main outcome was an Excel-based tool that communicates the overall cost/benefit of PSMI for the post-operative patient encounter. Results The VRT aggregated input data on costs, clinical impact, and nursing burden of PSMI assessment and monitoring into two high-level outcome reports: Overall Cost Impact and Nurse & Patient Impact. Costs included PSMI specific medication, equipment, professional placement, labor, overall/opioid-related adverse events, re-admissions, and length of stay. Nursing impact included level of practice interference, job satisfaction, and patient care metrics. Patient impact included pain scores, opioid use, PACU time, and satisfaction. Reference data was provided for individual institutions that may not collect all variables included in the VRT. Conclusions The VRT is a valuable way for administrators to assess PSMI cost/benefits and for individual cost centers to see the overall value of individual interventions. The user-friendly, decision-support tool allows the end-user to use built-in referenced or personalized outcome data, increasing relevance to their institutions. This broad picture could facilitate communication across cost centers and evidence-based decisions for appropriate use and impacts of PSMI.
Low-Power Multiple-Precision Iterative Floating-Point Multiplier with SIMD Support

The demand for improved SIMD floating-point performance on general-purpose x86-compatible microprocessors is rising. At the same time, there is a conflicting demand in the low-power computing market for a reduction in power consumption. Along with this, there is the absolute necessity of backward compatibility for x86-compatible microprocessors, which includes the support of x87 scientific floating-point instructions. The combined effect is that there is a need for low-power, low-cost floating-point units that are still capable of delivering good SIMD performance while maintaining full x86 functionality. This paper presents the design of an x86-compatible floating-point multiplier (FPM) that is compliant with the IEEE-754 Standard for Binary Floating-Point Arithmetic and is specifically tailored to provide good SIMD performance in a low-cost, low-power solution while maintaining full x87 backward compatibility. The FPM efficiently supports multiple precisions using an iterative rectangular multiplier. The FPM can perform two parallel single-precision multiplies every cycle with a latency of two cycles, one double-precision multiply every two cycles with a latency of four cycles, or one extended-double-precision multiply every three cycles with a latency of five cycles. The iterative FPM also supports division, square-root, and transcendental functions. Compared to a previous design with similar functionality, the proposed iterative FPM has 60 percent less area and 59 percent less dynamic power dissipation.
Patient optimization for gastrointestinal cancer surgery

Although surgical resection remains the central element in curative treatment of gastrointestinal cancer, increasing emphasis and resource has been focused on neoadjuvant or adjuvant therapy. Developments in these modalities have improved outcomes, but far less attention has been paid to improving oncological outcomes through optimization of perioperative care.
Favoritism and Financial Incentives: A Natural Experiment

Principals who exercise favouritism towards certain agents may harm those who are not so favoured. Other papers have produced evidence consistent with the presence of such favouritism but have been unable to consider methods for controlling it. We address this issue in the context of a natural experiment from English soccer, where one particular league introduced professional referees in 2001-02, thereby changing the financial incentives and monitoring regime faced by these referees. Because the change was not effected in all leagues, the ‘experiment’ has both cross-sectional and intertemporal dimensions. We study the effects of professional referees on an established measure of referee bias: length of injury time in close matches. We find that referees exercised favouritism prior to professionalism but not afterwards, having controlled for selection and soccer-wide effects. The results are consistent with a financial incentive effect as a result of professional referees and indicate that subtle aspects of principal-agent relationships (such as favouritism) are amenable to contractual influence.
Saturn: A scalable framework for error detection using Boolean satisfiability

This article presents Saturn, a general framework for building precise and scalable static error detection systems. Saturn exploits recent advances in Boolean satisfiability (SAT) solvers and is path sensitive, precise down to the bit level, and models pointers and heap data. Our approach is also highly scalable, which we achieve using two techniques. First, for each program function, several optimizations compress the size of the Boolean formulas that model the control flow and data flow and the heap locations accessed by a function. Second, summaries in the spirit of type signatures are computed for each function, allowing interprocedural analysis without a dramatic increase in the size of the Boolean constraints to be solved. We have experimentally validated our approach by conducting two case studies involving a Linux lock checker and a memory leak checker. Results from the experiments show that our system scales well, parallelizes well, and finds more errors with fewer false positives than previous static error detection systems.
One-bit massive MIMO: Channel estimation and high-order modulations

We investigate the information-theoretic throughout achievable on a fading communication link when the receiver is equipped with one-bit analog-to-digital converters (ADCs). The analysis is conducted for the setting where neither the transmitter nor the receiver have a priori information on the realization of the fading channels. This means that channel-state information needs to be acquired at the receiver on the basis of the one-bit quantized channel outputs. We show that least-squares (LS) channel estimation combined with joint pilot and data processing is capacity achieving in the single-user, single-receive-antenna case. We also investigate the achievable uplink throughput in a massive multiple-input multiple-output system where each element of the antenna array at the receiver base-station feeds a one-bit ADC. We show that LS channel estimation and maximum-ratio combining are sufficient to support both multiuser operation and the use of high-order constellations. This holds in spite of the severe non-linearity introduced by the one-bit ADCs.
Orbit segmentation by surface reconstruction with vertex screening

We suggest a computational approach to the orbit segmentation for computer tomography (CT) images. The first step was to perform Hounsfield unit thresholding to segment the bony structure. Then a three dimensional (3D) mesh model was generated. Poisson surface reconstruction was applied to the screened vertices that lay on the inner orbital walls. These procedures effectively interpolate the broken surfaces due to orbital fissures; various nerves foramina; and thin bone structure around the orbit. A validation was performed on the CT images of a dried skull with dental impression material filled orbits. The volume differences are 2.2 and 1.5% respectively for the two orbits. Surface differences are within ±0.46mm RMS. The differences are not clinically significant. The main novelty of proposed method is the ability in selecting vertices according to the desired orientation and therefore it is robust against broken structure in the segmentation.
Growth and Democracy : The Good , the Bad , and the Indifferent

Democracy is more than just another brake or booster for the economy. We argue that there are significant indirect effects of democracy on growth through public health and education. Where economists use life expectancy and education as proxies for human capital, we expect democracy will be an important determinant of the level of public services manifested in these indicators. In addition to whatever direct effect democracy may have on growth, we predict an important indirect effect through public policies that condition the level of human capital in different societies. We conduct statistical investigations into the direct and indirect effects of democracy on growth using a data set consisting of a 30-year panel of 128 countries. We find that democracy has no statistically significant direct effect on growth. Rather, we discover that the effect of democracy is largely indirect through increased life expectancy in poor countries and increased secondary education in nonpoor countries.
Normering och validering av ätstörningsformuläret KUS-P : Hur ätstörd är det normalt att vara?

Kort Upprepad Skattning av Atstorningssymptom- Patientversion (KUS-P) ar ett sjalvskattningsformular, avsett att mata de vanligaste symptomen hos personer med atstorningar. Formularet har anvants .
Immunization with an adjuvant hepatitis B vaccine in liver transplant recipients: Antibody decline and booster vaccination with conventional vaccine

Patients after orthotopic liver transplantation (OLT) due to hepatitis B virus (HBV)‐related disease are at risk of endogenous hepatitis B reinfection and may receive life long prophylaxis with hepatitis B hyperimmunoglobulin (HBIG). In a previous study 16 of 20 OLT patients were immunized successfully with an adjuvant hepatitis B vaccine. To maintain protective antibody levels under immunosuppressive therapy, 11 of these patients were revaccinated with a double dosed conventional hepatitis B vaccine. Median interval between last vaccination and booster was 24 months (range 22‐31 months). Antibody titres against hepatitis B surface antigen (anti‐HBs) were monitored at the day of booster vaccination (day 0), at day 7 and day 28. At day 0, all vaccinees but one had anti‐HBs titres greater than 500 IU/L (median 1,925 IU/L, range 196‐7,612 IU/L). Maximum antibody titres after previous vaccination declined by a median of 82% (range 47‐96%). After booster vaccination the anti‐HBs titre increased significantly by a median factor of 2.42 (P<0.05). In conclusion, the majority of liver transplant recipients who previously had responded to adjuvant hepatitis B vaccine exhibited sufficient immunocompetence to produce a substantial antibody response after booster immunization with a conventional vaccine. Liver Transpl 12:316–319, 2006. © 2006 AASLD.
CYP3A-Mediated Generation of Aldehyde and Hydrazine in Atazanavir Metabolism

Atazanavir (ATV) is an antiretroviral drug of the protease inhibitor class. Multiple adverse effects of ATV have been reported in clinical practice, such as jaundice, nausea, abdominal pain, and headache. The exact mechanisms of ATV-related adverse effects are unknown. It is generally accepted that a predominant pathway of drug-induced toxicity is through the generation of reactive metabolites. Our current study was designed to explore reactive metabolites of ATV. We used a metabolomic approach to profile ATV metabolism in mice and human liver microsomes. We identified 5 known and 13 novel ATV metabolites. Three potential reactive metabolites were detected and characterized for the first time: one aromatic aldehyde, one α-hydroxyaldehyde, and one hydrazine. These potential reactive metabolites were primarily generated by CYP3A. Our results provide a clue for studies on ATV-related adverse effects from the aspect of metabolic activation. Further studies are suggested to illustrate the impact of these potential reactive metabolites on ATV-related adverse effects.
Reliability analysis for MPSoCs with mixed-critical, hard real-time constraints

Methods such as rollback and modular redundancy are efficient to correct transient errors. In hard real-time systems, however, correction has a strong impact on response times, also on tasks that were not directly affected by errors. Due to deadline misses, these tasks eventually fail to provide correct service. In this paper we present a reliability analysis for periodic task sets and static priorities that includes realistic detection and roll-back scenarios and covers a hyperperiod instead of just a critical instant and therefore leads to much higher accuracy than previous approaches. The approach is compared with Monte-Carlo simulation to demonstrate the accuracy and with previous approaches covering critical instants to evaluate the improvements.
In vivo adenovirus-mediated p53 tumor suppressor gene therapy for colorectal cancer.

BACKGROUND The p53 tumor suppressor gene is altered in up to 70% of colorectal cancers. MATERIALS AND METHODS We infected the colorectal cancer cell lines SW620 and KM12L4, in which p53 is mutated, with the replication-defective adenovirus Ad5/CMV/p53 to evaluate the effects of adenovirus-mediated wild-type p53 gene transfer. Gene transduction was measured by cytochemical staining of cells infected with the Ad5/CMV/beta-gal virus and expression of the wildtype p53 protein in these cells was demonstrated by immunoblotting. RESULTS Significant suppression of in vitro cell proliferation and induction of apoptosis (as measured by TUNEL assay labeling) were observed following Ad5/CMV/p53 infection. More importantly, similar effects were observed in vivo in an established nude mouse subcutaneous tumor model; significant suppression of tumor growth (60%-70%) and induction of apoptosis were observed following intratumoral injections of Ad5/CMV/p53. CONCLUSION This form of therapy may provide a novel approach to colorectal cancer.
Draft Genome Sequence of the Type Species of the Genus Citrobacter, Citrobacter freundii MTCC 1658

ABSTRACT We report the 5.0-Mb genome sequence of the type species of the genus Citrobacter, Citrobacter freundii strain MTCC 1658, isolated from canal water. This draft genome sequence of C. freundii strain MTCC 1658T consists of 5,001,265 bp with a G+C content of 51.61%, 4,691 protein-coding genes, 70 tRNAs, and 10 rRNAs.
Detecting Spam Blogs: A Machine Learning Approach

Weblogs or blogs are an important new way to publish information, engage in discussions, and form communities on the Internet. The Blogosphere has unfortunately been infected by several varieties of spam-like content. Blog search engines, for example, are inundated by posts from splogs - false blogs with machine generated or hijacked content whose sole purpose is to host ads or raise the PageRank of target sites. We discuss how SVM models based on local and link-based features can be used to detect splogs. We present an evaluation of learned models and their utility to blog search engines; systems that employ techniques differing from those of conventional web search engines.
Three stages prediction-error expansion reversible watermarking

This paper proposes a three-stages difference expansion reversible watermarking scheme. In the first stage, a quarter of the pixels are estimated by using the median of the eight original neighbors of the 3×3 window. In the second stage, a quarter of the pixels are estimated as the average on the rhombus of the four horizontal and vertical original pixels. Finally, the remaining pixels are estimated on the rhombus context, using the modified pixels computed in the two previous stages. The experimental results show that the proposed scheme can provide slightly improved results than the classical two-stages reversible watermarking based on the rhombus context.
Image indexing and retrieval based on human perceptual color clustering

We propose a new image retrieval method based on human perceptual clustering of color images. This color clustering produces for each image a small set of representative colors which captures the color properties of the image, and a small set of sizable contiguous regions which captures the spatial/geometrical properties of the image. The proposed method outperforms the traditional histogram and its improved methods not only with its richer image retrieval capabilities which cover a wider spectrum of user requirements, but also with its powerful indexing scheme which is essential to cater for large scale image databases.
Research on Modeling Face-to-face Conversation

The following list contains a survey of some important and recent research in modeling face-to-face conversation. The list below is a presented as a guide to the literature by topic and date; we include complete citations afterwards in alphabetical order. For brevity, research works are keyed by first authorand date only (we use these keys on the slides as well as in this list). Of course, most papers are multiply authored. The list is not intended to be exhaustive. Our primary aim is simply to provide bibliographic information for all the research that we will refer to during the ESSLLI class itself. The entries also provide a sampling from ongoing research projects so that you can get an overall sense of the state of the field and begin to follow up topics of particular interest to you.
The incidence and nature of bedload transport during flood flows in coarse‐grained alluvial channels

A continuous record reveals that the incidence of bedload in a coarse-grained river channel changes from flood to flood. Long periods of inactivity encourage the channel bed to consolidate sufficiently so that bedload is largely confined to the recession limb of the next flood-wave. But when floods follow each other closely, the bed material is comparatively loose and offers less resistance to entrainment. In this case, substantial amounts of bedload are generated on the rising limb. This is confirmed by values of bed shear stress or stream power at the threshold of initial motion which can be up to five times the overall mean in the case of isolated floods or those which are the first of the season. This produces a complicated relationship between flow parameters and bedload and explains some of the difficulties in establishing bedload rating curves for coarse-grained channels. Besides this, the threshold of initial motion is shown to occur at levels of bed shear stress three times those at the thresholds of final motion. This adds further confusion to attempts at developing predictive bedload equations and clearly indicates at least one reason why equations currently in use are unsatisfactory. Bedload is shown to be characterized by a series of pulses with a mean periodicity of 1.7 hours. In the absence of migrating bedforms, it is speculated that this well-documented pattern reflects the passage of kinematic waves of particles in a slow-moving traction carpet. The general pattern of bedload, including pulsations, is shown to occur more or less synchronously at different points across the stream channel.
Code-Switching and Code-Mixing: Style of Language Use in Childhood in Yoruba Speech Community

This article is the report of an investigation into the types of languages acquired at different periods in the lives of members of the education elite in a speech community; to wit, the Ikale in the Irele and Okitipupa Local Government Areas of Ondo State. Through the questionnaire administered on about fifty respondents of the target population, the researcher could establish that the average child of the community starts to become bilingual from the primary school stage of his education. This, in effect, makes code-switching and code-mixing manifest in the child’s linguistic performance right from his early age. The implication is that, since both phenomena correlate positively with the educational attainment of individuals, English language teachers should devise the means of preventing the demerits of code-switching and code-mixing from adversely affecting the language acquisition process of the child.