Miracle-dz/UniFAR-FTUs huggingface dataset:
Meditation therapy for anxiety disorders.

BACKGROUND Anxiety disorders are characterised by long term worry, tension, nervousness, fidgeting and symptoms of autonomic system hyperactivity. Meditation is an age-old self regulatory strategy which is gaining more interest in mental health and psychiatry. Meditation can reduce arousal state and may ameliorate anxiety symptoms in various anxiety conditions. OBJECTIVES To investigate the effectiveness of meditation therapy in treating anxiety disorders SEARCH STRATEGY Electronic databases searched include CCDANCTR-Studies and CCDANCTR-References, complementary and alternative medicine specific databases, Science Citation Index, Health Services/Technology Assessment Text database, and grey literature databases. Conference proceedings, book chapters and references were checked. Study authors and experts from religious/spiritual organisations were contacted. SELECTION CRITERIA Types of studies: Randomised controlled trials. TYPES OF PARTICIPANTS patients with a diagnosis of anxiety disorders, with or without another comorbid psychiatric condition. Types of interventions: concentrative meditation or mindfulness meditation. Comparison conditions: one or combination of 1) pharmacological therapy 2) other psychological treatment 3) other methods of meditation 4) no intervention or waiting list. Types of outcome: 1) improvement in clinical anxiety scale 2) improvement in anxiety level specified by triallists, or global improvement 3) acceptability of treatment, adverse effects 4) dropout. DATA COLLECTION AND ANALYSIS Data were independently extracted by two reviewers using a pre-designed data collection form. Any disagreements were discussed with a third reviewer, and the authors of the studies were contacted for further information. MAIN RESULTS Two randomised controlled studies were eligible for inclusion in the review. Both studies were of moderate quality and used active control comparisons (another type of meditation, relaxation, biofeedback). Anti-anxiety drugs were used as standard treatment. The duration of trials ranged from 3 months (12 weeks) to 18 weeks. In one study transcendental meditation showed a reduction in anxiety symptoms and electromyography score comparable with electromyography-biofeedback and relaxation therapy. Another study compared Kundalini Yoga (KY), with Relaxation/Mindfulness Meditation. The Yale-Brown Obsessive Compulsive Scale showed no statistically significant difference between groups. The overall dropout rate in both studies was high (33-44%). Neither study reported on adverse effects of meditation. AUTHORS' CONCLUSIONS The small number of studies included in this review do not permit any conclusions to be drawn on the effectiveness of meditation therapy for anxiety disorders. Transcendental meditation is comparable with other kinds of relaxation therapies in reducing anxiety, and Kundalini Yoga did not show significant effectiveness in treating obsessive-compulsive disorders compared with Relaxation/Meditation. Drop out rates appear to be high, and adverse effects of meditation have not been reported. More trials are needed.
A NSFD Scheme for the Solving Fractional-Order Competitive Prey-Predator System

‎In this paper‎, ‎we introduce fractional--order into a model competitive Lotka-Volterra prey-predator system‎. ‎We will discuss the stability analysis of this fractional system‎. ‎The nonstandard finite difference (NSFD) scheme is implemented‎ ‎to study the dynamic behaviors in the fractional-order Lotka-Volterra system‎. Proposed ‎‎‎nonstandard ‎numerical ‎scheme ‎is ‎compared ‎with ‎the ‎forward ‎Euler ‎and ‎fourth ‎order ‎Runge-Kutta ‎methods. ‎‎‎‎‎Numerical results show that the‎ ‎NSFD approach is easy and accurate for ‎‎implementing ‎when ‎applied to fractional-order Lotka-Volterra model.
Heat Maps: A Technique for Classifying and Analyzing Drinking Behavior

Heat maps are presented here as an innovative technique for evaluating longitudinal drinking outcomes. The Life Transitions Study followed alcohol dependent individuals for 2.5 years during 2004–2009 in a Midwestern city (N = 364). The TimeLine Follow-Back obtained drinking information. Heat map results were compared with those obtained using growth mixture modeling. Heat map classes differed significantly on baseline clinical and demographic indicators. Data were gathered with support from NIAAA R01AA014442.
Lean six sigma approach for global supply chain management using industry 4.0 and IIoT

Global Supply Chain Management is the management of supply chains located globally. Quality control methods such as Lean and Six Sigma are used for improving efficiency and quality of production and distribution carried out by global supply chains. Lean Six Sigma eliminates unnecessary processes and defects which can benefit an enterprise from reduced costs and less wastage of resources. Industry 4.0 refers to automation of industries by the exchange of data between the supply chain and logistics. Industrial internet of things (IIoT) is industrial machines connected to the enterprise cloud storage area for data storage as well as data retrieval. Industry 4.0 along with IIoT can make a big revolution in the management of global supply chain. Lean Six Sigma approach in global supply chain using Industry 4.0 and IIoT creates an ideal process flow that is highly optimized as well as perfect and free from defects and wastage. The models proposed in this paper make the supply chain fully autonomous.
Algorithm Runtime Prediction: Methods and Evaluation (Extended Abstract)

Perhaps surprisingly, it is possible to predict how long an algorithm will take to run on a previously unseen input, using machine learning techniques to build a model of the algorithm’s runtime as a function of problem-specific instance features. Such models have many important applications and over the past decade, a wide variety of techniques have been studied for building such models. In this extended abstract of our 2014 AI Journal article of the same title, we summarize existing models and describe new model families and various extensions. In a comprehensive empirical analyis using 11 algorithms and 35 instance distributions spanning a wide range of hard combinatorial problems, we demonstrate that our new models yield substantially better runtime predictions than previous approaches in terms of their generalization to new problem instances, to new algorithms from a parameterized space, and to both simultaneously.
MCT‐4, A511/basigin and EF5 expression patterns during early chick cardiomyogenesis indicate cardiac cell differentiation occurs in a hypoxic environment

We have identified the presence of the hypoxia marker EF5 in the stage 4/5 chick heart fields. This suggests that cardiac cell differentiation occurs in a relatively anaerobic environment. Monocarboxylate transporter (MCT) studies in adult cardiac myocytes have demonstrated that MCTs catalyze proton‐linked pyruvate and lactate transport activity. 5A11/Basigin is an ancillary protein that targets MCTs to the plasma membrane for their function. MCT‐4 expression is most evident in cells with a high glycolytic rate associated with hypoxic energy production. Subsequent to the immunohistochemical localization of EF5 in the early heart field, we continued in our analysis during stages 5 to 12 for the expression of indicators of cellular glycolytic metabolism in the developing heart, such as MCT‐4, MCT‐1, and 5A11 (Basigin/CD147). Our observations indicate that MCT‐4 and 5A11/Basigin are expressed early, in a differential left‐right pattern, in the bi‐lateral plate mesoderm, as the cardiac compartment is forming. At stage 11, MCT‐4/5A11 continues to be highly expressed in the myocardial wall of the looping heart, but not in the dorsal mesocardium. RT‐PCR analyses for MCT‐1, ‐4, and 5A11 indicate that MCT‐4 and 5A11 are expressed throughout precardiac, embryonic, and fetal stages in the heart. MCT‐1 is first detected in the heart on embryonic day 3 and then remains expressed throughout development to hatching. These results indicate that cardiac precursor cells are equipped for differentiating in a hypoxic environment using anaerobic metabolism for energy production. Developmental Dynamics 235:124–131, 2006. © 2005 Wiley‐Liss, Inc.
Analysis of effectiveness of knowledge sharing program(KSP) implementation in Indonesia

Since its launch in 2004, KSP has consistently acted as a policy consultation and knowledge exchange between Korea with partner countries to seek the most favorable policy options to overcome barriers to development. Knowledge exchange between countries meets immediate, operational knowledge gaps by fostering the sharing of countries’ experiences. Korea and Indonesia have been engaged in KSP since 2005, in the form of joint research among experts from both countries. Until 2015, KSP with Indonesia has provided 46 topics with useful recommendations in the social and economics fields. Based on discussions and observations until now, however, there has not been any ex-post evaluation regarding the effectiveness of KSP, therefore this research will be the first on this topic and aims assess the effectiveness of KSP implementation in Indonesia to provide useful recommendations for Korea and Indonesia to improve KSP in the coming years.
Incorporating Semantic Algebra in the MDA Framework

Denotational semantics is commonly used to precisely define the meaning of a programming language. This meaning is given by functions that map syntactic elements to mathematically well defined sets called semantic algebra. Models in semantic algebra need to be processed through reductions towards a normal-form in order to allow the verification of semantics properties. MDA is a current trend that shifts the focus and effort from implementation to models, metamodels and transformations during the development process. In order to put forward denotational semantics in the MDA vision, we turn semantic algebra into an useful domain-specific language. In this context, this paper describes our proposed MOF metamodel and ATL reductions between the generated models. The metamodel serves as abstract syntax for semantic algebra. It is useful for static semantics verifications. The reductions enable processing towards a normal-form to compare semantics. This process can be guided by using some rewrite system.
Chemokine receptor 5Delta32 mutation reduces the risk of acute rejection in liver transplantation.

BACKGROUND Chemokine receptor 5 (CCR-5) plays a central role in allograft rejection. CCR-5Delta32 mutation results in a non-functioning receptor. Homozygous CCR-5Delta32 patients show a significantly improved kidney graft survival rate compared to CCR-5 wild-type patients. Similar correlations between the CCR-5Delta32 genotype and acute rejection or graft survival rate were shown for heart, lung and islet cell transplantation. MATERIAL/METHODS The aim of this study was to examine CCR-5Delta32 and acute rejection after liver transplantation (OLT). 158 OLT patients were genotyped. Data of grafts and patients were collected prospectively into a transplant database. RESULTS There were no significant differences between groups regarding patient, donor or graft variables. CCR-5 wild-type patients had explicitly more acute rejection episodes (p=0.086) than patients with the heterozygous or homozygous Delta32-mutation. Homozygous Delta32 patients had no acute rejection episodes. 12.5% of heterozygous patients had one acute rejection episode as opposed to 30.6% of wild-type patients. Only wild-type patients experienced more than one rejection episode. CONCLUSIONS Patients with the Delta32-mutation might be candidates for a minimized immunosuppressive therapy. CCR-5 could be relevant as a target for a new therapeutic approach.
Regulation of Dopamine Transporter Function and Cell Surface Expression by D3 Dopamine Receptors*

D3 dopamine receptors are expressed by dopamine neurons and are implicated in the modulation of presynaptic dopamine neurotransmission. The mechanisms underlying this modulation remain ill defined. The dopamine transporter, which terminates dopamine transmission via reuptake of released neurotransmitter, is regulated by receptor- and second messenger-linked signaling pathways. Whether D3 receptors regulate dopamine transporter function is unknown. We addressed this issue using a fluorescent imaging technique that permits real time quantification of dopamine transporter function in living single cells. Accumulation of the fluorescent dopamine transporter substrate trans-4-[4-(dimethylamino)styryl]-1-methylpyridinium (ASP+) in human embryonic kidney cells expressing human dopamine transporter was saturable and temperature-dependent. In cells co-expressing dopamine transporter and D3 receptors, the D2/D3 agonist quinpirole produced a rapid, concentration-dependent, and pertussis toxin-sensitive increase of ASP+ uptake. Similar agonist effects were observed in Neuro2A cells and replicated in human embryonic kidney cells using a radioligand uptake assay in which binding to and activation of D3 receptors by [3H]dopamine was prevented. D3 receptor stimulation activated phosphoinositide 3-kinase and MAPK. Inhibition of either kinase prevented the quinpirole-induced increase in uptake. D3 receptor activation differentially affected dopamine transporter function and subcellular distribution depending on the duration of agonist exposure. Biotinylation experiments revealed that the rapid increase of uptake was associated with increased cell surface and decreased intracellular expression and increased dopamine transporter exocytosis. In contrast, prolonged agonist exposure reduced uptake and transporter cell surface expression. These results demonstrate that D3 receptors regulate dopamine transporter function and identify a novel mechanism by which D3 receptors regulate extracellular dopamine concentrations.
Anamorphicons: an Extended Display Utilizing a Cylindrical Mirror Widget

We propose an interactive system that implements the technique of Anamorphosis, with a flat-panel display and a cylindrical mirror. In this system, a distorted image is shown on a flat-panel display or a tabletop surface, and the original image will appear on the cylindrical mirror when a user puts it on the display. By detecting the position and rotation angle of the cylinder, the system provides interaction between the user and the image on the cylinder. We developed three applications using this device.
Contribution of Na+‐Dependent and ATP‐Dependent Ca2+ Transport to Smooth Muscle Calcium Homeostasis a

Controversy has been longstanding as to the importance of Na+ -Ca2+ exchange in smooth muscle calcium homeostasis. ' Many investigators discounted the importance of this transport system because of its low calcium affinity and assumed that steady-state calcium regulation is dominated by ATP-dependent Ca'+transport. Few studies have measured Naf -dependent Ca2+ flux at submicromolar calcium levels, however. Thus the present studies examined the characteristics of Na+-dependent and ATP-dependent calcium uptake in plasma membrane vesicles derived from pig stomach muscle. Membrane vesicles enriched 15-20-fold for plasma membrane markers were prepared from pig gastric smooth muscle as described previously. ' Na+-Ca2+ exchange activity was assessed after 1, 5, or 15 seconds using a standard filtration assay in which Na+-loaded vesicles (preequilibrated with 130 mM NaCl) were diluted either into Na+-containing buffer (no gradient) or into K+-containing buffer (with gradient). Studies were carried out at 12°C and Na+-dependent uptake was defined as the difference in uptake in the presence versus the absence of a transmembrane Na+ gradient. Uptake of label occurred rapidly, plateauing within 5-10 seconds and the Na+dependent component was relatively small, 15-20% of the total uptake. However, this component appeared to reflect true vesicular uptake since it was inhibited by 20 p M dichlorobenzamil (65% reduction, p < 0.01) and by 1 pM monensin (100% reduction,p < 0.001), and since the label was released on reversal of the transmembrane Na+ gradient. Na-dependent Ca2+ uptake was observed over a wide range of Ca" concentrations. The rate of Na+-dependent Ca2+ accumulation increased with increasing Ca2+ levels between 1 and 100 pM, and the apparent KmC,-,) was 50 pM. Between 100 and lo00 nM Ca2+, Na+-dependent Ca2+ uptake showed little Ca2+dependency. However, the uptake observed between pCa 6.8 and 5.0 was appreciable, averaging -6 nmoles/ (min-mg protein) (FIG. 1). This transport was similar in magnitude to that observed for ATP-dependent Ca2+uptake; and as evident in FIGURE 2, Na+-dependent uptake constituted a significant portion of total calcium transport over a wide range of calcium levels. These findings, like those reported recently for bovine aortic smooth m ~ s c l e , ~
Impact of Leverage and Firm Size on Earnings Management in Indonesia

This study aimed to determine the effect of leverage and firm size toward earnings management. This study used a sample of the financial report data from manufacturing companies listed on the Indonesia stock exchange for the 2013-2017 period. The data analysis testing in this study employed EViews (Econometric Views). The results showed that the best panel regression model in this study was random effect model. Consistent with agency theory and positive accounting theory, leverage and firm size has a positive effect on the earnings management for manufacturing companies in Indonesia. The empirical results showed that leverage and firm size increases provide encouragement for managers to manipulate earnings.
Functional γ-Aminobutyrate Shunt in Listeria monocytogenes: Role in Acid Tolerance and Succinate Biosynthesis

ABSTRACT Listeria monocytogenes, the causative agent of human listeriosis, is known for its ability to withstand severe environmental stresses. The glutamate decarboxylase (GAD) system is one of the principal systems utilized by the bacterium to cope with acid stress, a reaction that produces γ-aminobutyrate (GABA) from glutamate. Recently, we have shown that GABA can accumulate intracellularly under acidic conditions, even under conditions where no extracellular glutamate-GABA exchange is detectable. The GABA shunt, a pathway that metabolizes GABA to succinate, has been described for several other bacterial genera, and the present study sought to determine whether L. monocytogenes has this metabolic capacity, which, if present, could provide a possible route for succinate biosynthesis in L. monocytogenes. Using crude protein extracts from L. monocytogenes EGD-e, we show that this strain exhibits activity for the two main enzyme reactions in the GABA shunt, GABA aminotransferase (GABA-AT) and succinic semialdehyde dehydrogenase (SSDH). Two genes were identified as candidates for encoding these enzyme activities, argD (GABA-AT) and lmo0913 (SSDH). Crude protein extracts prepared from a mutant lacking a functional argD gene significantly reduced GABA-AT activity, while an lmo0913 mutant lost all detectable SSDH activity. The deletion of lmo0913 increased the acid tolerance of EGD-e and showed an increased accumulation of intracellular GABA, suggesting that this pathway plays a significant role in the survival of this pathogen under acidic conditions. This is the first report of such a pathway in the genus Listeria, which highlights an important link between metabolism and acid tolerance and also presents a possible compensatory pathway to partially overcome the incomplete tricarboxylic acid cycle of Listeria.
Utility of a conceptual framework within doctoral study: A researcher's reflections

The author of this paper provides an example of a conceptual framework that supported her doctoral study and written dissertation in the field of educational psychology. The study was carried out prior to the more recent explicit emphasis on conceptual frameworks in postgraduate research texts and academic literature. The instigation for the development of an explicit conceptual framework was a change in supervisors and their need to be meaningfully included in the journey of the student. The conceptual framework supported the explanation of the multiple theoretical frameworks and literature base, as well as the professional educational context of the study. It also explicitly responded to the literature search in each area, clearly articulating theory and practice in school curriculum and assessment. This in turn supported the definition of research themes and research questions, and the research methodology (data gathering and analysis), from which the meaningful consideration of results could emerge and be shown to be conceptually coherent. The conceptual framework served as a reference for the supervisory relationship, and an organising structure for the written thesis. It also provided a tool of metacognition for the author as she actively constructed and used her conceptual framework to support her doctoral study.
A case of late-onset Tourette's disorder successfully treated with aripiprazole: View from blood levels of catecholamine metabolites and brain-derived neurotrophic factor (BDNF)

We reported a case with late-onset Tourette's disorder (TD) in whom motor tics and emotional instability improved with 18 mg/day of aripiprazole treatment. Plasma HVA levels, but not MHPG levels, were altered during the treatment. In contrast, serum BDNF levels remained consistently low during the treatment course. The present case suggests that aripiprazole might ameliorate tics and emotional instability via influencing dopaminergic neurons in late-onset TD.
Phytochemical Distribution and Bioactivity of Different Parts and Leaf Positions of Pimenta Dioica (L.) Merr (Myrtaceae)

Pimenta dioica (L.) Merr. (Myrtaceae) is an evergreen aromatic spice widely used in perfumery, food and cosmetic industry in many parts of the world. Present study compared Total Antioxidant Capacity (TAC), Total Phenolic Content (TPC), Total Flavonoid Content (TFC), leaf area (LA), and Fresh to Dry weight ratio of Pimenta dioica leaves at different leaf positions (1st, 2nd, 3rd, 4th and 5th leaf positions) and different plant parts (immature leaf, mature leaf and bark). The TAC, TPC and TFC were determined using Ferric Reducing Antioxidant Power Assay (FRAP), modified Folin–Ciocalteu colorimetric method and calorimetric method respectively. Significantly higher TAC 562.38 ± 9.42 (mg TE/g DW), TPC 279.53±7.02 (mg GAE/g DW) were observed in leaf extract obtained from 1st leaf position. However the highest TFC 303.48 ±8.87 (mg RE/g DW) was observed in 5th leaf position. According to phytochemical distribution pattern, significantly higher TAC [619.84 ±11.98 (mg TE/g DW)], TPC [267.53 ± 5.03(mg GAE/g DW)], TFC [305.48 ±8.87 (mg RE/g DW)] were observed in extracts obtained from bud region. The potential of Pimenta dioica leaf material and bark as a fabulous raw material for food, perfumery and cosmetic industries. Further harvesting of immature leaves could be suggested for better therapeutic benefits.