Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification et simulation d'une classe de processus stables autosimilaires a accroissements stationnaires

Cette these est consacree a l'etude d'une classe de processus symetriques -stables, a valeurs reelles, h-autosimilaires a accroissements stationnaires indexes par r d (ss h-sssi). En particulier, on s'interesse a l'estimation du parametre de hurst h, 0 < h < 1, et de l'indice de stabilite , 0 < < 2. Ce manuscrit se compose de trois parties. La premiere partie porte sur l'identification de deux classes de processus ss, 1 < < 2, a valeurs reelles h-sssi : les processus a moyenne mobile et ceux obtenus comme une transformee de fourier, dits processus harmonisables. Leur parametre de hurst h est estime au moyen de variations d'ordre p des accroissements du processus, pour tout 0 < p <. On donne en outre une estimation theorique des normes l p() du processus suivant une direction sur la sphere unite de r d. La deuxieme partie propose une estimation jointe des parametres h et de ces memes processus au moyen de variations quadratiques. Pour cela, on introduit un principe de localisation qui permet de tronquer les grands sauts d'une mesure aleatoire stable sur un domaine borne. Grace a ce principe, il devient possible d'utiliser des variations quadratiques de coefficients d'ondelettes du processus stable etudie. On donne des estimateurs de l'indice de stabilite d'une mesure aleatoire ss ainsi que de l'ordre d'operateurs pseudo-differentiels associes, d'ou l'on deduit l'estimation du parametre d'autosimilarite h. La troisieme partie porte sur la simulation du processus a moyenne mobile x. Pour un domaine d'etude et une precision fixes, on donne un mode de construction d'un processus simule qui est aussi proche que souhaite du processus x en norme l p. A partir d'une analyse multiresolution de x, ce processus simule est obtenu comme somme finie d'ondelettes adaptees pour laquelle les grands sauts de la mesure de poisson sous-jacente ont ete tronques.
Visualization of Oscillation Mode Shapes and Participation Factors

Power system oscillations can cause a power system to become unstable if they are too large. The oscillation modes and participation factors are crucial data for the analysis of system oscillations. But on large systems, there can be thousands of data points to look at. The goal of this work is to take oscillation mode shape and participation factor data and display it, so that one can quickly obtain the important information. These displays allow system operators and others interested in the system oscillations to quickly determine which generators are contributing to the oscillations and how each generator’s contribution compares to others. Because different users prefer different ways to visualize information, many options have been considered, including changing colors, sizes, and shapes. Both twodimensional and three-dimensional displays will be demonstrated.
MONODEHYROASCORBATE REDUCTASE4 Is Required for Seed Storage Oil Hydrolysis and Postgerminative Growth in Arabidopsis[W]

Hydrogen peroxide is a major by-product of peroxisomal metabolism and has the potential to cause critical oxidative damage. In all eukaryotes, catalase is thought to be instrumental in removing this H2O2. However, plants also contain a peroxisomal membrane–associated ascorbate-dependent electron transfer system, using ascorbate peroxidase and monodehydroascorbate reductase (MDAR). Here, I report that the conditional seedling-lethal sugar-dependent2 mutant of Arabidopsis thaliana is deficient in the peroxisomal membrane isoform of MDAR (MDAR4). Following germination, Arabidopsis seeds rely on storage oil breakdown to supply carbon skeletons and energy for early seedling growth, and massive amounts of H2O2 are generated within the peroxisome as a by-product of fatty acid β-oxidation. My data suggest that the membrane-bound MDAR4 component of the ascorbate-dependent electron transfer system is necessary to detoxify H2O2, which escapes the peroxisome. This function appears to be critical to protect oil bodies that are in close proximity to peroxisomes from incurring oxidative damage, which otherwise inactivates the triacylglycerol lipase SUGAR-DEPENDENT1 and cuts off the supply of carbon for seedling establishment.
Who adopts the Airbnb innovation? An analysis of international visitors to Western Australia

ABSTRACT Airbnb is the most prominent example of novel peer-to-peer networks in tourism. This new form of accommodation provision may alter demand structures in tourism destinations and has led to uncertainty amongst established accommodation providers and destination marketers. To gain a better understanding of Airbnb adopters, this paper systematically compares actual travel behaviour of Airbnb users in a specific destination with that of visitors staying in traditional accommodation. Due to this controlled comparison, the paper is the first one to offer a robust comparative profiling of Airbnb users. The analysis is based on a logistic regression of data from the standardised International Visitor Survey for 2015 in Western Australia. Results indicate that Airbnb users in Western Australia differ from visitors staying in traditional accommodation, but that it might be wrong to conceive Airbnb adopters to be ‘alternative tourists’ beyond the mainstream.
ANALISA PENGARUH ACCOUNTING INFORMATION SYSTEM TERHADAP COMPETITIVE ADVANTAGE MELALUI KNOWLEDGE MANAGEMENT PADA INDUSTRI PERHOTELAN DI SURABAYA

This research was conducted to find out the influence of Accounting Information System Against competitive advantage Through Knowledge Management as intervening variable in the hospitality industry located in Surabaya. Competitive advantage became one of the most important variables that was able to measure the hospitality ability. An other variables that was accounting information system had contribution in creating competitive advantage of the company. On the other hand, the application of accounting information system could not be separated from the support of knowledge management that were in the hotel. Data analysis techniques used in this research was the partial least square to describe the relationships between variables. The research results showed that the accounting information system and knowledge management affected the competitive advantage in a positive and significant in the hospitality industry located in Surabaya.
Work-Family Conflict, Stress and Psychological Strain in Higher Education

Work and family life are two important dimensions of human life that are hard to be separated. The incompatibility between these two domains is proven to increase stress and psychological strain. Thus, this research aims to investigate the impact of work-family conflict on stress and psychological strain among university staffs. A survey method using questionnaire was carried out to obtain the data for this study. A total of 267 respondents participated in this study, giving the return rate of 20% from the entire of population. The data were analyzed using correlation and multiple regression. Result indicated that both work to family conflict and family to work conflict have a significant relationship with the stress dimensions and psychological strain. In specific, work-to-family conflicts have a high correlation with the criterion variables compared to family-to-work conflict. In addition, the regression results indicated that only work to family conflict influence stress levels and psychological strain. In conclusion, this research hopes to enhance the knowledge in the realm of work-family conflict on stress and psychological strain among academic staffs in Malaysian higher institution.
Expression of neuronal nicotinic acetylcholine receptor genes in the developing chick visual system.

Expression of the neuronal non‐alpha nicotinic acetylcholine receptor (n alpha nAChR) gene is transiently stimulated in the chick optic tectum between embryonic days 7 and 16 with a peak value reached around embryonic day 12. This stimulation takes place at the time when optic nerve axons are invading this region of the brain and proceeds along a rostral to caudal gradient. Transcripts of the n alpha nAChR gene are localized in the superficial layers of the tectum at the time when cells in these layers are forming synapses with retina axons. The transient expression of n alpha nAChR gene does not take place in the optic tectum of ‘eyeless’ embryos. The results of our study suggest that the neuronal n alpha nAChR gene may play a role in neurogenesis of retino‐tectal connections.
Involvement of Myc Activity in a G1/S-Promoting Mechanism Parallel to the pRb/E2F Pathway

ABSTRACT The retinoblastoma protein (pRb)/E2F pathway regulates commitment of mammalian cells to replicate DNA. On the other hand, mitogen-stimulated cells deprived of E2F activity can still maintain physiologically relevant levels of cyclin E-dependent kinase activity and gradually enter S phase, suggesting the existence of a DNA synthesis-inducing mechanism parallel to the pRb/E2F axis. Here we show that regulatable ectopic expression of cyclin E or transcriptionally active Myc can rapidly induce DNA synthesis in U2OS-derived cell lines whose E2F activity is blocked by a constitutively active pRb (pRbΔcdk) mutant. The effect of Myc is associated with Cdc25A phosphatase and cyclin E-CDK2 kinase activation and abolished by antagonizing Myc activity with the dominant-negative (dn) MadMyc chimera. Moreover, while abrogation of either endogenous E2F or Myc activity only delays and lowers DNA synthesis in synchronized U2OS cells or rat diploid fibroblasts, concomitant neutralization of both abolishes it. Whereas ectopic Myc and E2F1 rescue the G1/S delay caused by pRbΔcdk (or dnDP1) and MadMyc, respectively, cyclin E or Cdc25A can restore DNA replication even in cells concomitantly exposed to pRbΔcdk and MadMyc. However, coexpression of dnCDK2 neutralizes all of these rescuing effects. Finally, proper transcription of cyclin E and Cdc25A at the G1/S transition requires both Myc and E2F activities, and subthreshold levels of ectopic cyclin E and Cdc25A synergistically restore DNA synthesis in cells with silenced Myc and E2F activities. These results suggest that Myc controls a G1/S-promoting mechanism regulating cyclin E-CDK2 in parallel to the “classical” pRb/E2F pathway.
H‐2 associated resistance to leukaemia transplantation: Natural killing in vivo

Natural resistance in vivo was studied by injecting non‐immunized mice with leukaemia cells prelabelled with the thymidine analogue 131I‐iododeoxyuridine. There was a decrease in the survival of the leukaemia cell inoculum as determined by whole‐body gamma counting, and a failure of the leukaemia cells to survive in the spleens of mice which were not H‐2 identical with the transplant. H‐2‐associated resistance could be measured within 24 h of leukaemia inoculation and was strongest in the spleen and absent from the liver. Although all strains of mice tested were able to resist H‐2 non‐identical cells, resistance in irradiated (800‐900 R) mice was restricted to certain strains and their F1 hybrids, notably those of the C57BL family. Resistance in both non‐irradiated and irradiated mice was not due to classical immunological rejection. Mice with either genetic or induced T‐cell deficiency showed full resistance, and circulating preformed antibody could not account for the rejection observed. Treatment with silica or with 89Sr abrogated natural resistance in non‐irradiated as well as irradiated animals; these treatments had previously been shown to abolish both bone‐marrow graft rejection in irradiated mice and in vitro natural killing. Resistance against leukaemia transplantation in irradiated C57BL mice appeared to depend on Hh‐I (H‐2D) incompatibility between the host and the graft, again suggesting that bone‐marrow graft rejection, and perhaps natural killer activity, is a subset of a more general paraimmune or non‐adaptive rejection mechanism.
Unusual stenosis of trachea in an adult.

HAVING chosen after due consideration a cuffed endotracheal tube, and having achieved the accepted conditions of anaesthesia and relaxation for its introduction, the anaesthetist normally and rightly expects to achieve his objective without much further trouble. After passing the bevelled end through the glottis, the further progress of the tube is usually easy unless an error has been made in the size of the tube chosen or unless the attachment of the cuff should prove faulty. Eventual failure to introduce a plain, oral tube, two sizes smaller than the original choice, farther than a few centimetres beyond the cords confirms a growing suspicion of possible abnormalities and calls for investigation. We encountered such circumstances in the following case:
DHyANA: A NoC-based neural network hardware architecture

Understanding and modeling the brain is one of the key scientific challenges in the twenty-first century, and a grown effort is rising on a global scale. Due to its high parallelism, the hardware implementation of large-scale spiking neural networks (SNNs) promises superior execution speed compared to sequential software approaches. Such systems can significantly benefit from the use of networks-on-chip(NoC), as they scale very well concerning area, performance, power/energy consumption, and overall design effort. We developed a hierarchical network-on-chip for a hardware SNN architecture to improve the communication and scalability of the system. The architecture was implemented in an Altera Stratix IV FPGA, and a logic synthesis was performed to evaluate the system, achieving an area of 0.23mm2 and a power dissipation of 147mW for a 256 neurons implementation.
Analysis on the Microbial Diversity of Qinghai High Salt Content Oil Reservoirs

Cultivation method and sequencing analysis of 16S rRNA genes were applied to analyze the microbial diversity of Qinghai oil reservoirs. The results of culture demonstrated that there existed a phylogenetically diverse and complex microbial community in Qinghai oil field formation. 10% randomly selected clones were analyzed by DNA sequencing. Sequencing of representative clones of each phylotype showed that the community structure was mainly constituted by Marinobacterium and Psudomonas, and there were some kinds of uncultured microbe existed in the sample. The results of this study provide further insight into the composition of microbial communities of high salt content oil reservoirs.
A novel current steering charge pump with low current mismatch and variation

A charge pump circuit to minimize current mismatch and current variation over a wide voltage compliance range is proposed. A feedback loop is used to cancel both deterministic and random mismatches between charging and discharging current to minimize PLL reference spurs and static phase offset. A current compensation circuit is used to minimize current variation to avoid bandwidth variation and loop instability. The circuit can operate at low supply voltage. The power overhead due to added circuitry is 3.36% making it suitable for low-power and low-voltage applications. The proposed current-steering charge pump circuit achieves mismatch lower than 0.44% over the output voltage range from 0.06 V to 0.85 V. Also the current variation is reduced to less than 1.19% when the output voltage varies from 0.06 V to 0.85 V in the 65 nm CMOS process with 1 V supply.
Changing Revealed Comparative Advantage: A Case Study of Footwear Industry of Pakistan

The global export patterns are changing fast as a result of reduction in trade barriers and technological advancements that have led to gains in productivity and change in comparative advantage patterns in world economies. Asian economies such as China and India are enjoying a notable growth in changing circumstances across the world. Pakistan also has great potential for higher growth however the political threats, socioeconomic environment and lack of updated technologies are obstruction in the way of progress. Some sectors of Pakistan economy have shown a good performance in terms of production and exports. Footwear is one such industry which has increased its exports at large extent since 2003. This sector has pivotal importance in terms of providing and creating jobs, earning of foreign exchange with the help of exports and fulfilling the local consumption requirements. Both in Pakistan and around the globe, the demand for footwear is increasing. Pakistan is one of the most populous countries in the World and according to an estimate with an average population growth of 2.25 percent, about 3 million children have been born during the year 2005-06, signaling the growing demand for footwear in Pakistan. It is also estimated that about 60 percent of the World’s total consumption consists of simple footwear made entirely of non-leather materials and that for the remaining 40 percent only the upper part of the shoe is made of leather. In the manufacturing of footwear, most frequently used material consists upon leather, man-made materials, rubber / canvas / synthetic and textile along accessories. Different type of shoes are being produced by the local industry e.g. sportsmen, army, disabled persons and safety shoes for the industrial workers etc. The population of Pakistan is expected to be about 172 million in the year 2010. Keeping in view the growth in population, the growth in the demand of footwear industry is also anticipated.
Blockade of Fas Signaling in Breast Cancer Cells Suppresses Tumor Growth and Metastasis via Disruption of Fas Signaling-initiated Cancer-related Inflammation*

Background: The non-apoptotic functions of Fas signaling have been proposed to play an important role in promoting tumor progression. Results: Blockade of Fas signaling suppresses tumor growth and metastasis via disruption of Fas signaling-initiated cancer-related inflammation. Conclusion: Fas signaling-initiated cancer-related inflammation in breast cancer cells may be a potential target for cancer treatment. Significance: This study provides mechanistic insight into the role of Fas signaling in cancer-related inflammation. Mechanisms for cancer-related inflammation remain to be fully elucidated. Non-apoptotic functions of Fas signaling have been proposed to play an important role in promoting tumor progression. It has yet to be determined if targeting Fas signaling can control tumor progression through suppression of cancer-related inflammation. In the current study we found that breast cancer cells with constitutive Fas expression were resistant to apoptosis induction by agonistic anti-Fas antibody (Jo2) ligation or Fas ligand cross-linking. Higher expression of Fas in human breast cancer tissue has been significantly correlated with poorer prognosis in breast cancer patients. To determine whether blockade of Fas signaling in breast cancer could suppress tumor progression, we prepared an orthotopic xenograft mouse model with mammary cancer cells 4T1 and found that blockade of Fas signaling in 4T1 cancer cells markedly reduced tumor growth, inhibited tumor metastasis in vivo, and prolonged survival of tumor-bearing mice. Mechanistically, blockade of Fas signaling in cancer cells significantly decreased systemic or local recruitment of myeloid derived suppressor cells (MDSCs) in vivo. Furthermore, blockade of Fas signaling markedly reduced IL-6, prostaglandin E2 production from breast cancer cells by impairing p-p38, and activity of the NFκB pathway. In addition, administration of a COX-2 inhibitor and anti-IL-6 antibody significantly reduced MDSC accumulation in vivo. Therefore, blockade of Fas signaling can suppress breast cancer progression by inhibiting proinflammatory cytokine production and MDSC accumulation, indicating that Fas signaling-initiated cancer-related inflammation in breast cancer cells may be a potential target for treatment of breast cancer.
Hypothesis: the reversal of the relation between economic growth and health progress in Sweden in the nineteenth and twentieth centuries was caused by electrification

Abstract The expected decline of health indicators with economic recessions and improvement with economic growth in the nineteenth century Sweden was reversed in the twentieth century, giving the counterintuitive pattern of higher mortality and lower life expectancy in economic expansions and improvement of these indices in recessions. The change or “tipping point” occurred at the end of the nineteenth century or early in the twentieth century when electrification was introduced into Sweden. All 5 of the reversals of annual industrial electric energy use in the US between 1912 and 1970 were accompanied by recessions with lowered GDP, increased unemployment, decreased mortality and increased life expectancy. The health indices were not related to residential electricity use. The mortality improvement between 1931 and 1932 by state in the US strongly favored urban areas over rural areas. Rural unemployment by state in 1930 was significantly positively correlated with residential electrification percentage by state in 1930. The health effects of economic change are mediated by electrical exposure.
Antimalarial Asexual Stage-Specific and Gametocytocidal Activities of HIV Protease Inhibitors

ABSTRACT The stage-specific antimalarial activities of a panel of antiretroviral protease inhibitors (PIs), including two nonpeptidic PIs (tipranavir and darunavir), were tested in vitro against Plasmodium falciparum. While darunavir demonstrated limited antimalarial activity (effective concentration [EC50], >50 μM), tipranavir was active at clinically relevant concentrations (EC50, 12 to 21 μM). Saquinavir, lopinavir, and tipranavir preferentially inhibited the growth of mature asexual-stage parasites (24 h postinvasion). While all of the PIs tested inhibited gametocytogenesis, tipranavir was the only one to exhibit gametocytocidal activity.
Chitosan/double‐stranded RNA nanoparticle‐mediated RNA interference to silence chitin synthase genes through larval feeding in the African malaria mosquito (Anopheles gambiae)

The purpose of this study was to examine whether the expression of two chitin synthase genes, AgCHS1 and AgCHS2, can be repressed by chitosan/AgCHS dsRNA‐based nanoparticles through larval feeding in Anopheles gambiae. The AgCHS1 transcript level and chitin content were reduced by 62.8 and 33.8%, respectively, in the larvae fed on chitosan/AgCHS1 dsRNA nanoparticles compared with those of the control larvae fed on chitosan/GFP dsRNA nanoparticles. Our study suggested for the first time that RNA interference (RNAi) in mosquito larvae is systemic, and demonstrated that the larvae fed on the nanoparticles assembled from AgCHS1 and AgCHS2 dsRNA increased larval susceptibilities to diflubenzuron, and calcofluor white (CF) or dithiothreitol, respectively. These results suggest great potential for using such a nanoparticle‐based RNAi technology for high‐throughput screening of gene functions and for developing novel strategies for pest management.