Miracle-dz/UniFAR-FTUs huggingface dataset:
Illness Beliefs in End Stage Renal Disease and Associations with Self-Care Modality Choice

Background Interest in self-care haemodialysis (HD) has increased because it improves patients’clinical and quality-of-life outcomes. Patients who undertake self-management for haemodialysis may hold illness beliefs differently to those choosing institutional care at the time of making the modality choice or moulded by their illness and dialysis treatment experience. Illness perceptions amongst predialysis patients and in those undertaking fully-assisted and self-care haemodialysis are being investigated in a combined cross-sectional and longitudinal study. Study Design The study data are derived from the BASIC-HHD study, a multicentre observational study on factors influencing home haemodialysis uptake. 535 patients were enrolled into three groups: Predialysis CKD-5 group, prevalent ‘in-centre’ HD and self-care HD groups (93% at home). We explore illness perceptions in the cross-sectional analyses of the three study groups, using the revised Illness Perception Questionnaire (IPQ-R). Predialysis patients’ illness beliefs were reassessed prospectively, typically between 4 and 12 months after dialysis commencement. Results Illness belief subscales are significantly different between in-centre and self-care HD groups. In a step-wise hierarchical regression analysis, after adjustment for age, education, marital status, diabetes, dialysis vintage, depression, anxiety scores, and IPQ-R subscales, personal control (p = 0.01) and illness coherence (p = 0.04) are significantly higher in the self-care HD group. In the predialysis group, no significant associations were found between illness representations and modality choices. In prospectively observed predialysis group, scores for personal control, treatment control, timeline cyclical and emotional representations reduced significantly after commencing dialysis and increased significantly for illness coherence. Conclusions Illness beliefs differ between hospital and self-care haemodialysis patients. Patient’s affect and neurocognitive ability may have an important role in determining illness beliefs. The impact of modality upon illness representations may also be significant and remains to be explored.
The Value of Client Access to Analyst Recommendations

Abstract Early access to stock recommendations provides brokerage firm clients with incremental investment value. After controlling for transaction costs, purchasing (selling) quickly following upgrades (downgrades) results in average two-day returns of 1.02% (1.50%). Short-term profit opportunities persist for two hours following the pre-market release of new recommendations. The results are robust within sub-periods and a calendar-based strategy produces positive abnormal daily returns of over 10 basis points, or roughly 30% annualized. Recommending firms' market makers shift their quotes accordingly, providing indirect evidence that clients make use of the informational advantage that arises from analysts' opinion changes.
Psychosocial Moderators of Emotional Reactivity to Marital Arguments

SUMMARY Several studies document that marital arguments negatively affect mental health. Yet it is also evident that considerable variability exists in emotional reactivity to marital arguments. One such piece of evidence is that wives are more emotionally reactive than are husbands. Using a close relationships perspective, this study explores reasons for this variability by identifying psychosocial characteristics of individuals and their marriages. The analysis is based on a daily diary study of 166 married couples who completed questionnaires each day for six weeks. These couples represent a subsample of a prior general population community panel study. Results show that wives' emotional reactivity is best explained by a model that includes extraversion, marital trust, being in a first marriage, and the percentage of total family income earned by the wife. Husbands' emotional reactivity is best explained by how frequently the couple argues on average, support from relatives, acute life events, and total family income. The paper concludes with a discussion of the implications for research on the mental health effects of marital distress.
Charles Bonnet Syndrome: Case series

Since its first description in 1760, Charles Bonnet syndrome (CBS) has been reported in many studies. The main characteristics are visual hallucinations, preserved awareness of unreal visions, and absence of psychotic symptoms. CBS can occur with lesions located anywhere along the central visual pathway, from the eye to the calcarine fissure. Objective To describe patients with CBS and carry out a review of the literature. Methods Six patients with visual hallucinations were evaluated in an outpatient memory clinic between 2001 and 2008, and their clinical characteristics recorded. Results Four patients were female, and the mean age was 74.5±16.9 years. Three patients had visual loss secondary to eye disease and three due to cerebral lesions. The visions consisted of animals, persons, moving objects, bizarre creatures or colored forms, and were considered disturbing by five patients. Five patients received treatment, and only three reported partial benefit from the therapy. Complete recovery was not seen in any of the subjects. Conclusions CBS is relatively rare and its recognition is important to avoid misdiagnoses with psychiatric or dementing illnesses.
On User Recommendations Based on Multiple Cues

In this paper we present an overview of a recommender system that attempts to predict user preferences based on several sources including prior choices and selected user-defined features. By using a combination of collaborative filtering and semantic features, we hope to provide performance superior to either alone. Further, our set of semantic features is acquired and updated using a learning-based procedure that avoids the need for manual knowledgeengineering. Our system is implemented in a web-based application server environment and can be used with arbitrary domains, although the test data reported here is restricted to recommendations of movies.
Mechanisms of resistance to EGFR-targeted drugs: lung cancer

Despite the improvement in clinical outcomes derived by the introduction of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs) in the treatment of patients with advanced non-small cell lung cancer (NSCLC) whose tumours harbour EGFR-activating mutations, prognosis remains unfavourable because of the occurrence of either intrinsic or acquired resistance. We reviewed the published literature and abstracts of oral and poster presentations from international conferences addressing EGFR-TKIs resistance mechanisms discovered in preclinical models and in patients with NSCLC. The molecular heterogeneity of lung cancer has several implications in terms of possible mechanisms of either intrinsic or acquired resistance to EGFR-targeted inhibitors. Several mechanisms of resistance have been described to EGFR-TKIs, such as the occurrence of secondary mutation (T790M, C797S), the activation of alternative signalling (Met, HGF, AXL, Hh, IGF-1R), the aberrance of the downstream pathways (AKT mutations, loss of PTEN), the impairment of the EGFR-TKIs-mediated apoptosis pathway (BCL2-like 11/BIM deletion polymorphism) and histological transformation. Although some of the mechanisms of resistance have been identified, much additional information is needed to understand and overcome resistance to EGFR-TKI agents. The majority of resistance mechanisms described are the result of a selection of pre-existing clones; thus, studies on the mechanisms by which subclonal alterations have an impact on tumour biology and influence cancer progression are extremely important in order to define the best treatment strategy.
Transforming to DevOps with Junos OS

Traditional information technology service management (ITSM) methods establish disparate test and production systems that often consume vast operational resources while adding an equal amount of complexity during the service creation and upkeep process. DevOps is the unification of systems developers and operators use for continuous delivery of services with higher quality and faster service creation, at a lower price. This white paper is for network systems developers and operators who wish to transform operations models for their Juniper-based Internet Protocol (IP) networking infrastructures using IT DevOps methodologies. The paper will examine how specific features and capabilities of Juniper Networks ® Junos ® operating system, the OS that powers all Juniper routers, switches, and firewalls, not only integrate into existing IT DevOps environments but also help build and maintain networks for continuous delivery—a key concept of DevOps.
The Research on the Impact of Green Beans Sports Drinks on Relieving Fatigue in Sports Training

For researching the function of relieving fatigue of green beans sports drinks, this paper selected 60 mice as subjects. They were randomly divided into four groups (low dose group, middle dose group, high dose group and physiological saline group). Each time they were respectively feed 10g 20g/L, 40g/L, 80 g/L green beans sports drinks and 15ml/(kg.d) physiological saline. The experiment lasted for a month. We recorded weight of mice, swimming time and blood urea nitrogen indicators. The results show that green beans sports drinks can significantly prolong swimming time of mice (p <0.05). For serum urea the results show no effect. So green beans sports drinks have a certain function of relieving physical fatigue.
A Taste of Crispy Squid

Distributed proxy caches are in use throughout the world to reduce access latency and bandwidth demands for Internet object transfer. The CRISP project seeks to build more eeective distributed Web caches by exploring alternatives to the hierarchical structure and multicast handling of probes common to the most popular distributed Web cache systems. CRISP caches are structured as a collective of autonomous Web proxy servers sharing their cache directories through a common mapping service that can be queried with at most one message exchange. Individual servers may be conngured to replicate all or part of the global map in order to balance access cost, overhead and hit ratio, depending on the size and geographic dispersion of the collective cache. We have prototyped several CRISP cache structures in Crispy Squid, an extension to the Squid Internet Object Cache. We are evaluating these cache structures using Proxycizer, a full-featured package for replaying traces of observed request traac into Web cache prototypes.
Overexplaining or underexplaining methane’s role in climate change

Methane lies at the nexus of climate and air quality, being both a major anthropogenic greenhouse gas—causing about one-half of the warming of carbon dioxide—and a precursor of tropospheric ozone pollution. Over the industrial era, atmospheric methane abundances rose from about 720 parts per billion (ppb) (10−9 mole fraction) to over 1,850 ppb today. Humans have driven this change largely through agriculture, waste, and fossil fuel emissions. The community’s regular review of the science of atmospheric methane via the Intergovernmental Panel on Climate Change (IPCC) Assessment Reports [First Assessment Report (FAR), 1990 (1); Second Assessment Report (SAR), 1995 (2); Third Assessment Report (TAR), 2001 (3); Fourth Assessment Report (AR4), 2007 (4); and Fifth Assessment Report (AR5), 2013 (5)] has maintained both a scientific interest and political urgency as nations seek to mitigate near-term climate change and keep the overall warming to less than 2 °C (6⇓⇓–9). The recent history (Fig. 1), based on ref. 10, shows a complex overall growth with different rates and even a pause from 2000 to 2006. The many conflicting reports of this recent variability (11⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓–23) suggest that it remains unexplained, or perhaps overexplained. Past work has separately used measurements of methane, its isotopes, and related gases to interpret the methane history. Two new publications (24, 25) combine these complementary data into a consistent Bayesian modeling framework and use advanced statistical methods to match all observations simultaneously subject to the prior constraints. Notably, they advance our understanding of what could have caused the variability. The similarities and differences of optimal solutions that emerge from both studies teach us about the information contained in present observations, as well as their limits. Fig. 1. ( A ) Timeline of the international assessments … [↵][1]1To whom correspondence should be addressed. Email: mprather{at}uci.edu. [1]: #xref-corresp-1-1
Designing a system to capitalize both social and documentary resources

The wide adoption of social and connected tools in organizations lead them to think again about their behavior and to consider the indexing of the resources users can now produce with such tools, in the same way they index other documentary resources. This indexing process has to be done along the core frame of reference of the organization. We present in this paper the model of a system which permit the indexing with the help of an ontology of both documentary resources or those produced on a social platform resources.
Thyroid hormone action: demonstration of putative nuclear receptors in human lymphocytes.

ABSTRACT Lymphocytes isolated from hypothyroid patients contain high-affinity, limited-capacity, nuclear binding sites for triiodothyronine (T3). The estimated equilibrium dissociation constant was 3.08 × 10−11M. This value is virtually identical to that determined with GH1 cells, a rat pituitary tumor cell line, in culture. The maximal binding capacity was estimated to be 4 × 10−15 moles of T3 bound per 100 ug of lymphocyte DNA. This is equivalent to approximately 300 molecules of T3 bound per cell nucleus.
Mitral and Tufted Cells Are Potential Cellular Targets of Nitration in the Olfactory Bulb of Aged Mice

Olfactory sensory function declines with age; though, the underlying molecular changes that occur in the olfactory bulb (OB) are relatively unknown. An important cellular signaling molecule involved in the processing, modulation, and formation of olfactory memories is nitric oxide (NO). However, excess NO can result in the production of peroxynitrite to cause oxidative and nitrosative stress. In this study, we assessed whether changes in the expression of 3-nitrotyrosine (3-NT), a neurochemical marker of peroxynitrite and thus oxidative damage, exists in the OB of young, adult, middle-aged, and aged mice. Our results demonstrate that OB 3-NT levels increase with age in normal C57BL/6 mice. Moreover, in aged mice, 3-NT immunoreactivity was found in some blood vessels and microglia throughout the OB. Notably, large and strongly immunoreactive puncta were found in mitral and tufted cells, and these were identified as lipofuscin granules. Additionally, we found many small-labeled puncta within the glomeruli of the glomerular layer and in the external plexiform layer, and these were localized to mitochondria and discrete segments of mitral and tufted dendritic plasma membranes. These results suggest that mitral and tufted cells are potential cellular targets of nitration, along with microglia and blood vessels, in the OB during aging.
Civic-Minded Graduate: A North Star (Assessment Tools)

The attached items are associated with the "Civic-Minded Graduate: A North Star", an article published in the Michigan Journal of Community Service Learning (Fall 2011, Volume 18, No. 1). The items include the Civic-Minded Graduate (CMG)scale, CMG Narrative Prompt & associated Rubric, and CMG interview protocol & associated Rubric. For more information about these tools or for revised versions, please look for "Civic-Minded Graduate Tools" within the "Assessment" Collection or contact Kathy Steinberg (ksteinbe@iupui.edu) for more information. Or, visit the IUPUI Center for Service & Learning website at www.csl. iupui.edu
Novel chondroitin sulfate-binding cationic liposomes loaded with cisplatin efficiently suppress the local growth and liver metastasis of tumor cells in vivo.

An increased level of chondroitin sulfate (CS) expression on the cell surface is often associated with malignant transformation and the progression of tumor cells. In this study, CSs expressed on highly metastatic tumor cells were used as a target for the selective delivery of anticancer drugs by polyethylene glycol (PEG)-coated liposomes that contained a new cationic lipid 3,5-dipentadecycloxybenzamidine hydrochloride (TRX-20). We found that PEG-coated TRX-20 liposomes (TRX-20 liposomes) bound preferentially to certain CSs, such as CS B, CS D, and CS E, whereas PEG-coated liposomes lacking TRX-20 showed no significant binding to any of the glycosaminoglycans tested. In vitro, TRX-20 liposomes, but not plain PEG liposomes, avidly bound to and were readily internalized by highly metastatic tumor cells such as LM8G5 and ACHN cells, which express large amounts of CS on the cell surface. When TRX-20 liposomes were loaded with cisplatin, they effectively killed the CS-expressing tumor cells in vitro, whereas cisplatin-PEG liposomes lacking TRX-20 were totally ineffective. When injected systemically, TRX-20 liposomes preferentially accumulated in the liver and in solid s.c. LM8G5 tumors. Therapeutic experiments in mice bearing a s.c. LM8G5 tumor revealed that cisplatin-loaded TRX-20 liposomes were significantly more effective in reducing the local tumor growth than cisplatin-loaded plain PEG liposomes or free cisplatin. Furthermore, the cisplatin-loaded TRX-20 liposomes markedly suppressed metastatic spreading of LM8G5 tumor cells to the liver, significantly increasing the survival time of the tumor-bearing mice. These results demonstrate that the CS-targeted delivery of anticancer drugs by novel cationic liposomes represents a potentially useful strategy to prevent the local growth and metastasis, particularly to the liver, of tumor cells that have enhanced expression of CS.
Adaptive Evolutionary Filtering in Real-Time Twitter Stream

With the explosive growth of microblogging service, Twitter has become a leading platform consisting of real-time world wide information. Users tend to explore breaking news or general topics in Twitter according to their interests. However, the explosive amount of incoming tweets leads users to information overload. Therefore, filtering interesting tweets based on users' interest profiles from real-time stream can be helpful for users to easily access the relevant and key information hidden among the tweets. On the other hand, real-time twitter stream contains enormous amount of noisy and redundant tweets. Hence, the filtering process should consider previously pushed interesting tweets to provide users with diverse tweets. What's more, different from traditional document summarization methods which focus on static dataset, the twitter stream is dynamic, fast-arriving and large-scale, which means we have to decide whether to filter the coming tweet for users from the real-time stream as early as possible. In this paper, we propose a novel adaptive evolutionary filtering framework to push interesting tweets for users from real-time twitter stream. First, we propose an adaptive evolutionary filtering algorithm to filter interesting tweets from the twitter stream with respect to user interest profiles. And then we utilize the maximal marginal relevance model in fixed time window to estimate the relevance and diversity of potential tweets. Besides, to overcome the enormous number of redundant tweets and characterize the diversity of potential tweets, we propose a hierarchical tweet representation learning model (HTM) to learn the tweet representations dynamically over time. Experiments on large scale real-time twitter stream datasets demonstrate the efficiency and effectiveness of our framework.
The UV-Optical Galaxy Color-Magnitude Diagram. I. Basic Properties

We have analyzed the bivariate distribution of galaxies as a function of ultraviolet-optical colors and absolute magnitudes in the local universe. The sample consists of galaxies with redshifts and optical photometry from the Sloan Digital Sky Survey (SDSS) main galaxy sample matched with detections in the near-ultraviolet (NUV) and far-ultraviolet (FUV) bands in the Medium Imaging Survey being carried out by the Galaxy Evolution Explorer (GALEX) satellite. In the (NUV − r)0.1 versus Mr,0.1 galaxy color-magnitude diagram, the galaxies separate into two well-defined blue and red sequences. The (NUV − r)0.1 color distribution at each Mr,0.1 is not well fit by the sum of two Gaussians due to an excess of galaxies in between the two sequences. The peaks of both sequences become redder with increasing luminosity, with a distinct blue peak visible up to Mr,0.1 ∼ − 23. The r0.1-band luminosity functions vary systematically with color, with the faint-end slope and characteristic luminosity gradually increasing with color. After correcting for attenuation due to dust, we find that approximately one-quarter of the color variation along the blue sequence is due to dust, with the remainder due to star formation history and metallicity. Finally, we present the distribution of galaxies as a function of specific star formation rate and stellar mass. The specific star formation rates imply that galaxies along the blue sequence progress from low-mass galaxies with star formation rates that increase somewhat with time to more massive galaxies with a more or less constant star formation rate. Above a stellar mass of ~1010.5 M☉, galaxies with low ratios of current to past averaged star formation rate begin to dominate.
Commitment in Adult Mouse Thymus Fine-Scale Staging of T Cell Lineage

T cell development is marked by the loss of alternative lineage choices accompanying speciﬁcation and commitment to the T cell lineage. Commitment occurs between the CD4 and CD8 double-negative (DN) 2 and DN3 stages in mouse early T cells. To determine the gene regulatory changes that accompany commitment, we sought to distinguish and characterize the earliest committed wild-type DN adult thymocytes. A transitional cell population, deﬁned by the ﬁrst downregulation of surface c-Kit expression, was found to have lost the ability to differentiate into dendritic cells and NK cells when cultured without Notch-Delta signals. In the presence of Notch signaling, this subset generates T lineage descendants in an ordered precursor–product relationship between DN2, with the highest levels of surface c-Kit, and c-Kit–low DN3 cells. These earliest committed cells show only a few differences in regulatory gene expression, compared with uncommitted DN2 cells. They have not yet established the full expression of Notch-related and T cell differentiation genes characteristic of DN3 cells before b selection. Instead, the downregulation of select stem cell and non-T lineage genes appears to be key to the extinction of alternative lineage choices. The Journal of Immunology , 2010, 185: 284–293. by of alternative gd not