Miracle-dz/UniFAR-FTUs huggingface dataset:
Healthy Diet and Nutrition Education Program among Women of Reproductive Age: A Necessity of Multilevel Strategies or Community Responsibility.

BACKGROUND Reproductive years represent a major proportion of women‟s life. This review focuses on recommended nutritional considerations, physical activity pattern as well as the effect of nutrition education (NE) on behavior modification and health outcomes of women of reproductive age using either single-level, multiple-level or community-level interventions. METHODS For this narrative review, numerous searches were conducted on databases of PubMed, Science Direct and Google Scholar search engine using the keywords women, reproductive age, NE, interventions, community-based. RESULTS Even though single intervention is effective, multiple intervention programmes in addition to behavior modification components are even more successful in terms of modified behaviors and health outcomes. Moreover, community based interventions using multilevel strategies are further useful for improved health outcomes and behavior modification. CONCLUSION NE programmes have been effective in positive behavior modification measured in terms of eating pattern and health quality. Thus, it is recommended that health professionals use multiple intervention strategies at community level to ensure improved outcomes. Political support is also required to create culturally sensitive methods of delivering nutritional programmes. Finally, as policy is dependent on program cost, nutritional programmes need to combine methods of cost analysis to show cost effectiveness of supplying adequate nutrition for women throughout the lifecycle.
Behavioral Analysis of Visitors to a Medical Institution’s Website Using Markov Chain Monte Carlo Methods

Background Consistent with the “attention, interest, desire, memory, action” (AIDMA) model of consumer behavior, patients collect information about available medical institutions using the Internet to select information for their particular needs. Studies of consumer behavior may be found in areas other than medical institution websites. Such research uses Web access logs for visitor search behavior. At this time, research applying the patient searching behavior model to medical institution website visitors is lacking. Objective We have developed a hospital website search behavior model using a Bayesian approach to clarify the behavior of medical institution website visitors and determine the probability of their visits, classified by search keyword. Methods We used the website data access log of a clinic of internal medicine and gastroenterology in the Sapporo suburbs, collecting data from January 1 through June 31, 2011. The contents of the 6 website pages included the following: home, news, content introduction for medical examinations, mammography screening, holiday person-on-duty information, and other. The search keywords we identified as best expressing website visitor needs were listed as the top 4 headings from the access log: clinic name, clinic name + regional name, clinic name + medical examination, and mammography screening. Using the search keywords as the explaining variable, we built a binomial probit model that allows inspection of the contents of each purpose variable. Using this model, we determined a beta value and generated a posterior distribution. We performed the simulation using Markov Chain Monte Carlo methods with a noninformation prior distribution for this model and determined the visit probability classified by keyword for each category. Results In the case of the keyword “clinic name,” the visit probability to the website, repeated visit to the website, and contents page for medical examination was positive. In the case of the keyword “clinic name and regional name,” the probability for a repeated visit to the website and the mammography screening page was negative. In the case of the keyword “clinic name + medical examination,” the visit probability to the website was positive, and the visit probability to the information page was negative. When visitors referred to the keywords “mammography screening,” the visit probability to the mammography screening page was positive (95% highest posterior density interval = 3.38-26.66). Conclusions Further analysis for not only the clinic website but also various other medical institution websites is necessary to build a general inspection model for medical institution websites; we want to consider this in future research. Additionally, we hope to use the results obtained in this study as a prior distribution for future work to conduct higher-precision analysis.
AN EXTREME ANALOGUE OF ϵ AURIGAE: AN M-GIANT ECLIPSED EVERY 69 YEARS BY A LARGE OPAQUE DISK SURROUNDING A SMALL HOT SOURCE

We present TYC 2505-672-1 as a newly discovered and remarkable eclipsing system comprising an M-type red giant that undergoes a ∼3.45 year long, near-total eclipse (depth of ∼4.5 mag) with a very long period of ∼69.1 years. TYC 2505-672-1 is now the longest-period eclipsing binary system yet discovered, more than twice as long as that of the currently longest-period system, ϵ Aurigae. We show from analysis of the light curve including both our own data and historical data spanning more than 120 years and from modeling of the spectral energy distribution, both before and during eclipse, that the red giant primary is orbited by a moderately hot source (Teff ≈ 8000 K) that is itself surrounded by an extended, opaque circumstellar disk. From the measured ratio of luminosities, the radius of the hot companion must be in the range of 0.1–0.5 R⊙ (depending on the assumed radius of the red giant primary), which is an order of magnitude smaller than that for a main sequence A star and 1–2 orders of magnitude larger than that for a white dwarf. The companion is therefore most likely a “stripped red giant” subdwarf-B type star destined to become a He white dwarf. It is, however, somewhat cooler than most sdB stars, implying a very low mass for this “pre-He-WD” star. The opaque disk surrounding this hot source may be a remnant of the stripping of its former hydrogen envelope. However, it is puzzling how this object became stripped, given that it is at present so distant (orbital semimajor axis of ∼24 au) from the current red giant primary star. Extrapolating from our calculated ephemeris, the next eclipse should begin in early UT 2080 April and end in mid UT 2083 September (eclipse center UT 2081 December 24). In the meantime, radial velocity observations would establish the masses of the components, and high-cadence UV observations could potentially reveal oscillations of the hot companion that would further constrain its evolutionary status. In any case, this system is poised to become an exemplar of a very rare class of systems, even more extreme in several respects than the well studied archetype ϵ Aurigae.
Surgical Decompression for Space-Occupying Cerebral Infarction: Outcomes at 3 Years in the Randomized HAMLET Trial

Background and Purpose— We assessed whether the effects of surgical decompression for space-occupying hemispheric infarction, observed at 1 year, are sustained at 3 years. Methods— Patients with space-occupying hemispheric infarction, who were enrolled in the Hemicraniectomy After Middle cerebral artery infarction with Life-threatening Edema Trial within 4 days after stroke onset, were followed up at 3 years. Outcome measures included functional outcome (modified Rankin Scale), death, quality of life, and place of residence. Poor functional outcome was defined as modified Rankin Scale >3. Results— Of 64 included patients, 32 were randomized to decompressive surgery and 32 to best medical treatment. Just as at 1 year, surgery had no effect on the risk of poor functional outcome at 3 years (absolute risk reduction, 1%; 95% confidence interval, −21 to 22), but it reduced case fatality (absolute risk reduction, 37%; 95% confidence interval, 14–60). Sixteen surgically treated patients and 8 controls lived at home (absolute risk reduction, 27%; 95% confidence interval, 4–50). Quality of life improved between 1 and 3 years in patients treated with surgery. Conclusions— In patients with space-occupying hemispheric infarction, the effects of decompressive surgery on case fatality and functional outcome observed at 1 year are sustained at 3 years. Clinical Trial Registration— URL: http://www.controlled-trials.com. Unique identifier: ISRCTN94237756.
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

Loss of stromal fibroblast caveolin-1 (Cav-1) is a powerful single independent predictor of poor prognosis in human breast cancer patients, and is associated with early tumor recurrence, lymph node metastasis, and tamoxifen-resistance. We developed a novel co-culture system to understand the mechanism(s) by which a loss of stromal fibroblast Cav-1 induces a "lethal tumor micro-environment". Here, we propose a new paradigm to explain the powerful prognostic value of stromal Cav-1. In this model, cancer cells induce oxidative stress in cancer associated fibroblasts, which then acts as a "metabolic" and "mutagenic" motor to drive tumor-stroma co-evolution, DNA damage, and aneuploidy in cancer cells. More specifically, we show that an acute loss of Cav-1 expression leads to mitochondrial dysfunction, oxidative stress, and aerobic glycolysis in cancer associated fibroblasts. Also, we propose that defective mitochondria are removed from cancer-associated fibroblasts by autophagy/mitophagy that is induced by oxidative stress. As a consequence, cancer associated fibroblasts provide nutrients (such as lactate) to stimulate mitochondrial biogenesis and oxidative metabolism in adjacent cancer cells (the "Reverse Warburg Effect"). We provide evidence that oxidative stress in cancer associated fibroblasts is sufficient to induce genomic instability in adjacent cancer cells, via a bystander effect, potentially increasing their aggressive behavior. Finally, we directly demonstrate that nitric oxide (NO) over-production, secondary to Cav-1 loss, is the root cause for mitochondrial dysfunction in cancer associated fibroblasts. In support of this notion, treatment with anti-oxidants (such as N-acetyl-cysteine, metformin, and quercetin), or NO inhibitors (L-NAME) was sufficient to reverse many of the cancer-associated fibroblast phenotypes that we describe. Thus, cancer cells use "oxidative stress" in adjacent fibroblasts i) as an "engine" to fuel their own survival via the stromal production of nutrients, and ii) to drive their own mutagenic evolution towards a more aggressive phenotype, by promoting genomic instability. We also present evidence that the "field effect" in cancer biology could also be related to the stromal production of ROS and NO species. eNOS-expressing fibroblasts have the ability to down-regulate Cav-1 and induce mitochondrial dysfunction in adjacent fibroblasts that do not express eNOS. As such, the effects of stromal oxidative stress can be laterally propagated, amplified, and are effectively "contagious"-spread from cell-to-cell like a virus-creating an "oncogenic/mutagenic" field promoting widespread DNA damage.
Diagrams in Contracts: Fostering Understanding in Global Business Communication

Research problem: Business-to-business contracts are complex communication artifacts, often considered “legal stuff” and the exclusive domain of lawyers. However, many other stakeholders without a legal background are involved in the negotiation, drafting, approval, and implementation of contracts, and their contributions are essential for successful business relationships. How can we ensure that all stakeholders in the global business context—whatever their native language or professional background—easily and accurately understand contract documents? This study suggests that integrating diagrams in contracts can result in faster and more accurate comprehension, for both native and non-native speakers of English. Literature review: We focused on the following research topics: (1) ways to integrate text and visuals to create more effective instructions, since we conceptualize contracts as a type of business instructions; (2) cognitive load theory, as it may help explain why contracts are so hard to understand and why text-visuals integration may ameliorate their understandability; (3) cognitive styles, as individual differences may affect how individuals process verbal and visual information, thus allowing us to explore the limitations of our suggested approach; (4) the English lingua franca spoken by business professionals in international settings, their needs and challenges, and the fact that pragmatic approaches are needed to ensure successful communication. Methodology: We conducted an experiment with 122 contract experts from 24 countries. The research participants were asked to complete a series of comprehension tasks regarding a contract, which was provided in either a traditional, text-only version or in a version that included diagrams as complements to the text. In addition to measuring answering speed and accuracy, we asked the participants to provide information about their educational background, mother tongue, and perceived mental effort in task completion, and to complete an object–spatial imagery and verbal questionnaire to assess their cognitive style. Conclusions: We found that integrating diagrams into contracts supports faster and more accurate comprehension; unexpectedly, legal background and different cognitive styles do not interact with this main effect. We also discovered that both native and non-native speakers of English benefit from the presence of diagrams in terms of accuracy, but that this effect is particularly strong for non-native speakers. The implication of this study is that adding diagrams to contracts can help global communicators to understand such documents more quickly and accurately. The need for well-designed contracts may open new opportunities for professional writers and information designers. Future research may also go beyond experimental evaluations: by observing this new genre of contracts in vivo, it would be possible to shed light on how contract visualizations would be perceived and interpreted in a global communication environment.
Simultaneous determination of geniposide, chlorogenic acid, crocin1, and rutin in crude and processed Fructus Gardeniae extracts by high performance liquid chromatography

Background: Fructus Gardeniae, commonly used traditional Chinese medicine (TCM) called Zhizi in chinese, is derived from the dried fruit of Gardenia jasminoides Ellis of the Madder Family. To our knowledge, previously reported analytical methods were not developing for simultaneous determination of geniposide, chlorogenic acid, crocin1, and rutin in Fructus Gardeniae and its processed products of chaozheng pin (CZP) extracts. Materials and Methods: In this study, a HPLC method was developed for simultaneous determination four major active components in Fructus Gardeniae and its processed products. Results: The contents of geniposide, chlorogenic acid, crocin1, and rutin in Fructus Gardeniae samples analyzed were 2.492 - 4.242%, 0.162 - 0.407%, 0.417 -0.837%, and 0.116 - 0.251%, respectively. Conclusion: The developed method can be applied to the intrinsic quality control of Fructus Gardeniae.
Foreign Exchange News Announcements and the Volatility of Stock Returns in Nigeria

This paper examines the effect of foreign exchange news announcements on the volatility of stock returns in Nigeria, using the daily closing All-Share Index from The Nigerian Stock Exchange from 2000 to 2015. We extended existing literature by augmenting the EGARCH econometric model with exchange news announcements to specify both the conditional mean and volatility equations. The empirical results revealed a positive and significant effect of exchange news announcements on stock market volatility in Nigeria under symmetric conditional variance. However, there was strong evidence of asymmetric effect with negative exchange news which caused volatility to rise more following a large price rise than following a price fall of the same magnitude. The total impact of bad news had more distabilising effect on volatility than good news. The sum of ARCH and GARCH coefficients (α + β = 0.9) is approximately close to unity – indicating strong evidence of volatility persistence in the Nigerian stock market. JEL Classification: C22, C58 & G12
Functional association between viral and cellular transcription during influenza virus infection

Influenza viruses replicate and transcribe their segmented negative‐sense single‐stranded RNA genome in the nucleus of the infected host cell. All RNA synthesising activities associated with influenza virus are performed by the virally encoded RNA‐dependent RNA polymerase (RdRp) that consists of three subunits, PA, PB1 and PB2. However, viral transcription is critically dependent on on‐going cellular transcription, in particular, on activities associated with the cellular DNA‐dependent RNA polymerase II (Pol II). Thus, the viral RdRp uses short 5′ capped RNA fragments, derived from cellular Pol II transcripts, as primers for viral mRNA synthesis. These capped RNA primers are generated by cleavage of host Pol II transcripts by an endonuclease activity associated with the viral RdRp. Moreover, some viral transcripts require splicing and since influenza virus does not encode splicing machinery, it is dependent on host splicing, an activity also related to Pol II transcription. Despite these functional links between viral and host Pol II transcription, there has been no evidence that a physical association existed between the two transcriptional machineries. However, recently it was reported that there is a physical interaction between the trimeric viral RdRp and cellular Pol II. The viral RdRp was found to interact with the C‐terminal domain (CTD) of initiating Pol II, at a stage in the transcription cycle when capping takes place. It was therefore proposed that this interaction may be required for the viral RNA (vRNA) polymerase to gain access to capped RNA substrates for endonucleolytic cleavage. The virus not only relies on cellular factors to support its own RNA synthesis, but also subverts cellular pathways in order to generate an environment optimised for viral multiplication. In this respect, the interaction of the viral NS1 protein with factors involved in cellular pre‐mRNA processing is of particular relevance. The virus also alters the distribution of Pol II on cellular genes, leading to a reduction in elongating Pol II thereby contributing to the phenomenon known as host shut‐off. Copyright © 2006 John Wiley & Sons, Ltd.
Xanthomonas oryzae pv. oryzae avirulence genes contribute differently and specifically to pathogen aggressiveness.

Genomic copies of three Xanthomonas oryzae pv. oryzae avirulence (avr) genes, avrXa7, avrXal0, and avrxa5, and four homologous genes, aB3.5, aB3.6, aB4.3, and aB4.5, were mutagenized individually or in combination to study the roles of avr genes in one component of pathogen fitness, i.e., aggressiveness or the amount of disease X. oryzae pv. oryzae causes in susceptible rice lines. These X. oryzae pv. oryzae genes are members of the highly related Xanthomonas avrBs3 gene family. Compared to the wild-type strain, X. oryzae pv. oryzae strains with mutations in avrXa7, avrxa5, and the four homologous genes caused shorter lesions on rice line IR24, which contains no resistance genes relevant to the wild-type strain. The contribution of each gene to lesion length varied, with avrXa7 contributing the most and avrXal0 showing no measurable effect on aggressiveness. The functional, plasmidborne copies of avrXa7, aB4.5, and avrxa5 restored aggressiveness only to strains with mutations in avrXa7, aB4.5, and avrxa5, respectively. Mutations in avrXa7 were not complemented by plasmids carrying any other avr gene family members. These data indicate that some, but not all, avr family members contribute to pathogen aggressiveness and that the contributions are quantitatively different. Furthermore, despite their sequence similarity, the aggressiveness functions of these gene family members are not interchangeable. The results suggest that selection and pyramiding resistance genes can be guided by the degree of fitness penalty that is empirically determined in avr gene mutations.
Upregulation of glutamate transporter GLT‐1 by mTOR‐Akt‐NF‐кB cascade in astrocytic oxygen‐glucose deprivation

Excessive extracellular glutamate leads to neuronal death in central nervous system. Excitatory glutamate transporter subtype 2 (GLT‐1) carries bulk of glutamate reuptake in cerebral ischemia. Although GLT‐1 expression fluctuates during the period of ischemia, little is known about its regulatory mechanism. Here we show an up‐regulation of GLT‐1 via mammalian target of rapamycin (mTOR)‐Akt‐nuclear factor‐кB (NF‐кB) signaling cascade in oxygen glucose deprivation (OGD). We found that brief rapamycin treatment significantly increased GLT‐1 expression in cultured astrocytes. Rapamycin increased phosphorylation of raptor at Ser792 and decreased phosphorylation of rictor at Thr1135, suggesting that both mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) are involved in GLT‐1 expression. This conclusion was further confirmed by raptor and rictor disruption experiments. Akt was activated by mTORC1 inhibition and required for GLT‐1 expression because triciribine, a specific inhibitor of Akt, blocked the increase of GLT‐1 expression. mTOR‐Akt cascade then activated NF‐кB and increased кB‐motif‐binding phosphoprotein (KBBP) expression and GLT‐1 transcription. We next demonstrated that mTOR‐Akt‐NF‐кB cascade was activated in OGD and subsequently caused the upregulation of GLT‐1. Supporting evidence included: (1) inhibition of Akt or NF‐кB occluded OGD‐induced GLT‐1 upregulation; (2) Raptor knock‐down plus OGD did not add to the increase of GLT‐1 expression; (3) Intact mTORC2 was required for GLT‐1 enhancement. In summary, our data first showed that mTOR‐Akt‐NF‐кB cascade played critical roles to up‐regulate GLT‐1 in OGD. This signaling cascade may work to promote glutamate uptake in brain ischemia and neurodegenerative diseases. GLIA 2013;61:1959–1975
Histone Deacetylase AtHDA7 Is Required for Female Gametophyte and Embryo Development in Arabidopsis1[C][W][OPEN]

AtHDA7 is essential for female gametophyte development and embryogenesis in Arabidopsis. Histone modifications are involved in the regulation of many processes in eukaryotic development. In this work, we provide evidence that AtHDA7, a HISTONE DEACETYLASE (HDAC) of the Reduced Potassium Dependency3 (RPD3) superfamily, is crucial for female gametophyte development and embryogenesis in Arabidopsis (Arabidopsis thaliana). Silencing of AtHDA7 causes degeneration of micropylar nuclei at the stage of four-nucleate embryo sac and delay in the progression of embryo development, thereby bringing the seed set down in the Athda7-2 mutant. Furthermore, AtHDA7 down- and up-regulation lead to a delay of growth in postgermination and later developmental stages. The Athda7-2 mutation that induces histone hyperacetylation significantly increases the transcription of other HDACs (AtHDA6 and AtHDA9). Moreover, silencing of AtHDA7 affects the expression of ARABIDOPSIS HOMOLOG OF SEPARASE (AtAESP), previously demonstrated to be involved in female gametophyte and embryo development. However, chromatin immunoprecipitation analysis with acetylated H3 antibody provided evidence that the acetylation levels of H3 at AtAESP and HDACs does not change in the mutant. Further investigations are essential to ascertain the mechanism by which AtHDA7 affects female gametophyte and embryo development.