Miracle-dz/UniFAR-FTUs huggingface dataset:
Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics.

The microtubule cytoskeleton consists of a highly organized network of microtubule polymers bound to their accessory proteins: microtubule-associated proteins, molecular motors, and microtubule-organizing proteins. The microtubule subunits are heterodimers composed of one alpha-tubulin polypeptide and one beta-tubulin polypeptide that should undergo a complex folding processing before they achieve a quaternary structure that will allow their incorporation into the polymer. Due to the extremely high protein concentration that exists at the cell cytoplasm, there are alpha- and beta-tubulin interacting proteins that prevent the unwanted interaction of these polypeptides with the surrounding protein pool during folding, thus allowing microtubule dynamics. Several years ago, the development of a nondenaturing electrophoretic technique made it possible to identify different tubulin intermediate complexes during tubulin biogenesis in vitro. By these means, the cytosolic chaperonin containing TCP-1 (CCT or TriC) and prefoldin have been demonstrated to intervene through tubulin and actin folding. Various other cofactors also identified along the alpha- and beta-tubulin postchaperonin folding route are now known to have additional roles in tubulin biogenesis such as participating in the synthesis, transport, and storage of alpha- and beta-tubulin. The future characterization of the tubulin-binding sites to these proteins, and perhaps other still unknown proteins, will help in the development of chemicals that could interfere with tubulin folding and thus modulating microtubule dynamics. In this paper, current knowledge of the above postchaperonin folding cofactors, which are in fact chaperones involved in tubulin heterodimer quaternary structure achievement, will be reviewed.
Enhancer of Rudimentary Homolog Affects the Replication Stress Response through Regulation of RNA Processing

ABSTRACT Accurate replication of DNA is imperative for the maintenance of genomic integrity. We identified Enhancer of Rudimentary Homolog (ERH) using a whole-genome RNA interference (RNAi) screen to discover novel proteins that function in the replication stress response. Here we report that ERH is important for DNA replication and recovery from replication stress. ATR pathway activity is diminished in ERH-deficient cells. The reduction in ATR signaling corresponds to a decrease in the expression of multiple ATR pathway genes, including ATR itself. ERH interacts with multiple RNA processing complexes, including splicing regulators. Furthermore, splicing of ATR transcripts is deficient in ERH-depleted cells. Transcriptome-wide analysis indicates that ERH depletion affects the levels of ∼1,500 transcripts, with DNA replication and repair genes being highly enriched among those with reduced expression. Splicing defects were evident in ∼750 protein-coding genes, which again were enriched for DNA metabolism genes. Thus, ERH regulation of RNA processing is needed to ensure faithful DNA replication and repair.
Robust indoor positioning using differential wi-fi access points

Location positioning systems using wireless area local network (WLAN) infrastructure are considered cost effective and practical solutions for indoor location tracking and estimation. However, accuracy deterioration due to environmental factors and the need for manual offline calibration limit the application of these systems. In this paper, a new method based on differential operation access points is proposed to eliminate the adverse effects of environmental factors on location estimation. The proposed method is developed based on the operation of conventional differential amplifiers where noise and interference are eliminated through a differential operation. A pair of properly positioned access points is used as a differential node to eliminate the undesired effects of environmental factors. As a result the strength of received signals, which is used to determine the location of a user, remains relatively stable and supports accurate positioning. To estimate wave propagation in indoor environments, log-distance path loss model has been employed at the system level. Experimental results indicate that the proposed method can effectively reduce the location estimation error and provide accuracy improvement over existing methods.
Co‐morbidity in persistent opioid users with chronic non‐malignant pain in Norway

In patients with chronic non‐malignant pain (CNMP), co‐morbid physical or mental health disorders are common and may have a negative impact on health‐related quality of life and treatment outcomes. The purpose of this study was to examine the occurrence of chronic psychiatric and somatic diseases in persistent opioid users with CNMP compared with the general population in Norway.
Ontology Modelling of Malaysian Food Exchange List

Designing dietary menu planning is a complex problem-solving task. It involves several constraints and extensive common sense. Case-based reasoning (CBR) solves the complexity by storing an expert common sense in the case base. Case adaptation (CA) is important for design task using CBR since old cases are partially similar as a current one. An automatic CA mainly focused on the processing level rather than at the data level. On the other hand, semantic technology (ST) inserts the intelligence features by shifting the focus on the application code to the data. This can leverage the burden on the logical processing of adaptation engine. Ontology is a prerequisite in ST. Thus, this research proposes a computational model of design CA using an ontological approach. This paper discusses the experience we gained during the process of ontology modelling based on the OD101 method. The Malaysian food ontology was successfully developed to make the domain assumptions explicit in supporting the reasoning process of case adaptation for dietary menu planning recommendation.
Consumption-based Material Flow Accounting Austrian Trade and Consumption in Raw Material Equivalents 1995 – 2007

In 2007, imports accounted for approximately 34% of the material input (domestic extraction and imports) into the Austrian economy and almost 60% of the GDP stemmed from exports. Upstream material inputs into the production of traded goods, however, are not yet included in the standard framework of material flow accounting (MFA). We have reviewed different approaches accounting for these upstream material inputs, or raw material equivalents (RME), positioning them in a wider debate about consumption-based perspectives in environmental accounting. For the period 1995–2007, we calculated annual RME of Austria’s trade and consumption applying a hybrid approach. For exports and competitive imports, we used an environmentally extended input-output model of the Austrian economy, based on annual supply and use tables and MFA data. For noncompetitive imports, coefficients for upstream material inputs were extracted from life cycle inventories. The RME of Austria’s imports and exports were approximately three times larger than the trade flows themselves. In 2007, Austria’s raw material consumption was 30 million tonnes or 15% higher than its domestic material consumption. We discuss the material composition of these flows and their temporal dynamics. Our results demonstrate the need for a consumption-based perspective in MFA to provide robust indicators for dematerialization and resource efficiency analysis of open economies.
Physiology of status epilepticus in primates.

In adolescent baboons the intravenous injection of bicuculline induced generalized seizures lasting up to five hours, which sometimes led to brain damage or death. Marked initial rises in arterial and cerebral venous pressure were accompanied by severe metabolic and respiratory acidosis, hyperglycemia, and reduced cerebral arteriovenous (AV) differences for oxygen (O2) and carbon dioxide (CO2). In the second phase of the seizure (+25 to +300 minutes) blood pressure was normal or low, cerebral AV differences for O2 andCO wereenhanced, but cerebral venous oxygen tension was not critically reduced. There was severe hyperpyrexia, and hyperkalemia, and sometimes hypoglycemia. Death was cardiovascular in origin. A behavioral and electroencephalographic recovery could occur within three hours of generalized seizure activity lasting one to two hours.
Strong-Arm Bullying Prior to Incarceration Among a Sample of Young Offenders

Most studies of bullying behavior have been conducted with general populations during childhood and early adolescence. Although incarcerated youth are at increased risk for bullying others, incarcerated youth in the United States have rarely been studied regarding their bullying behavior prior to incarceration. Understanding the psychological and antisocial correlates of strong-arm bullying prior to incarceration may highlight risk factors that, if addressed, might reduce bullying and deter youth from further involvement in the juvenile justice system. This study examines self-reports of 723 youth incarcerated in the Missouri Division of Youth Services to determine the demographic, psychiatric, and substance-related factors associated with strong-arm bullying in the year prior to incarceration. Results indicate that younger youth from urban areas who have extensive histories of delinquent behavior are more likely than other incarcerated youth to strong-arm their peers. Youth exhibiting strong-arm bullying were also more likely than other youth to use cigarettes and alcohol. Further, strong-arm bullying is associated with severe offending, including gang membership and physical violence. These psychosocial correlates suggest behavioral targets for intervening to reduce bullying among delinquent youth.
Comment on Zekeri (2007)

Zekeri's comments (2007) on Bridges and Kunselman's work (2005) were not sufficiently grounded in sociological theory, the calculation of the “rates of potential years of life lost” (PYLL) was modified but unreported, and the use of PYLL, despite limitations as a measure of premature mortality “was not justified. ” The theoretical framework, however, consisted of “environmental” and “social group” statements which gave a specific means for grounding “premature mortality” in sociological theory, and findings were consistent with Lester's social deviancy theory of suicide (1989). How the “rates of PYLL” were calculated, i.e., by the Canadian government is misinterpreted, although Allard, et al. (2004) provided justification for the use of age-standardized rates of PYLL in their 2005 study.
Semi-supervised classification for rolling fault diagnosis via robust sparse and low-rank model

Rolling element bearings play an important role in ensuring the availability of industrial machines. Unexpected bearing failures in such machines during field operation can lead to machine breakdown, which may have some pretty severe implications. However, the insufficiency of labeled samples is major problem for handling fault diagnosis problem. To address such concern, we propose a semi-supervised method for diagnosing faulty bearings by utilizing unlabeled samples. The superiority of our algorithm has been validated by comparison with other state-of art methods based on a rolling element bearing data. The classification accuracy of bearing data show that our algorithm is able to recognize different bearing fault categories effectively. Thus, it can be considered as a promising method for fault diagnosis.
Body Awareness Rating Questionnaire: Measurement properties

The purpose of present study was to investigate important measurement properties of the Body Awareness Rating Questionnaire (BARQ) subscales: Function; Mood; Feelings; and Awareness. Samples of 50 patients with prolonged musculoskeletal pain and psychosomatic disorders, and 50 gender and age-matched healthy persons participated in the study. Relative (ICC 2,1) and absolute reliability (Sw) were calculated. Construct validity was examined by testing hypothesis using Pearson (r) or Spearman rank (rs) correlation. Discriminate ability was examined using a receiver operating characteristic (ROC) curve, the area under the curve (aROC) being the measure of discriminative validity. All patients reported more or less improvement after treatment, using the Patient Global Impression of Change (PGIC) as an external indicator of important change. Responsiveness to important change was therefore examined by one-way repeated measures analysis of variance (ANOVA), relating change scores of BARQ subscales to the PGIC categories. Relative and absolute reliability values were within recommended limits for all four subscales. Construct and discriminate validity was indicated for Function, Feelings and Awareness, but not for Mood. Responsiveness was indicated for the subscales Function and Awareness, but not for Feelings and Mood. Further research is needed to complement the subscales of BARQ, found with appropriate measurement properties.
Postpartum Depression in a General Pediatric Practice

Postpartum depression (PPD) is a common problem in new mothers. Untreated PPD is associated with behavioral and developmental problems in children. We examined the effects of an educational session about PPD and modification of the electronic medical record (EMR) on providers’ screening for PPD. An education session was given to the physicians and pre and post surveys compared comfort and self-reported screening. Following the EMR change, a retrospective chart review was conducted from three time periods: group 1—before the conference, group 2—after the conference but before EMR change, and group 3—after screening in the EMR. Documented screening increased from 0% in group 1, to 2% in group 2, to 74% in group 3 (P < .001). Ten percent screened positive, but only 14% had documented referrals to a provider for treatment. The combination of provider education and screening questions integrated into the EMR enhanced PPD screening rates among physicians in a busy practice.
Class Probability Propagation of Supervised Information Based on Sparse Subspace Clustering for Hyperspectral Images

Hyperspectral image (HSI) clustering has drawn increasing attention due to its challenging work with respect to the curse of dimensionality. In this paper, we propose a novel class probability propagation of supervised information based on sparse subspace clustering (CPPSSC) algorithm for HSI clustering. Firstly, we estimate the class probability of unlabeled samples by way of partial known supervised information, which can be addressed by sparse representation-based classification (SRC). Then, we incorporate the class probability into the traditional sparse subspace clustering (SSC) model to obtain a more accurate sparse representation coefficient matrix accompanied by obvious block diagonalization, which will be used to build the similarity matrix. Finally, the cluster results can be obtained by applying the spectral clustering on similarity matrix. Extensive experiments on a variety of challenging data sets illustrate that our proposed method is effective.
Toll-Like Receptor 4 Contributes to Colitis Development but Not to Host Defense during Citrobacter rodentium Infection in Mice

ABSTRACT Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) are noninvasive bacterial pathogens that infect their hosts' intestinal epithelium, causing severe diarrheal disease. These infections also cause intestinal inflammation, although the mechanisms underlying the inflammatory response, as well as its potential role in host defense, are unclear. Since these bacteria are gram-negative, Toll-like receptor 4 (TLR4), the innate receptor for bacterial lipopolysaccharide may contribute to the host response; however, the role of TLR4 in the gastrointestinal tract is poorly understood, and its impact has yet to be tested against this family of enteric bacterial pathogens. Since EPEC and EHEC are human specific, we infected mice with Citrobacter rodentium, a mouse-adapted attaching and effacing (A/E) bacterium that infects colonic epithelial cells, causing colitis and epithelial hyperplasia, using a similar array of virulence proteins as EPEC and EHEC. We demonstrated that C. rodentium activates TLR4 and rapidly induced NF-κB nuclear translocation in host cells in a partially TLR4-dependent manner. Infection of TLR4-deficient mice revealed that TLR4-dependent responses mediate much of the inflammation and tissue pathology seen during infection, including the induction of the chemokines MIP-2 and MCP-1, as well as the recruitment of macrophages and neutrophils into the infected intestine. Surprisingly, spread of C. rodentium through the colon was delayed in TLR4-deficient mice, whereas the duration of the infection was unaffected, indicating that TLR4-mediated responses against this A/E pathogen are not host protective and are ultimately maladaptive to the host, contributing to both the morbidity and the pathology seen during infection.
Operation of HVDC grids in parallel with AC grids

In this thesis, the operation of multi-terminal VSC-HVDC grids is investigated. The advantages of an HVDC grid are the possibility of transporting large amount of power over long distances and the possibility of trading energy among different AC systems. Due to the interest in the exploitation of clean energy sources, far away from consumption center, the idea of using an HVDC grid has become popular in the recent years. The DC voltage of the HVDC system has been identified to be an important parameter analogous to the frequency in AC systems. The variation of DC voltage indicates power unbalance in the DC grid. If the power is sustainably unbalanced, the DC voltage will either increase or decrease. The DC system dynamic, which is very fast, compared with AC system dynamic, demands fast actions; therefore, automatic measures must take place in order to keep the DC system stable. A control strategy, to balance the power in the HVDC system, has been proposed in this thesis. The control strategy proposes that, under contingencies, there is at least one converter that regulates the DC voltage, or in other words, balances power. In order to test the control strategy, a converter model was implemented with the help of the Dynamic Simulation Language (DSL) of SIMPOW. Also, a frequency regulation scheme that emulates machine governors is proposed and further tested in this thesis. The operation of an HVDC grid in parallel with AC grids is tested so that issues such as power oscillations and frequency control can be observed together with the DC grid dynamic. Simulation results show that, with the proposed control strategy, the DC grid remains stable after the simulated outages, even when the converter that regulates the DC voltage is lost. Other important result is that as long as the converters are within its limits, power oscillations don’t disturb the DC system at all. When one converter reaches its current limit and its respective AC system is undergoing power oscillations, they will be reflected in the DC grid and the perturbation could be transferred to another AC system. Also, a proposed frequency regulation scheme is, finally, tested and results show that it is feasible that two selected converters cooperate, effectively, on regulating the frequency in one AC system.
Organizing project-based group communication events: A macro perspective

Communication, often conducted in the form of meeting, is critical to the success of collaboration in project-based and human-intensive business activities. This paper reviews current literature in the areas of group and organizational communication and argues the need of (1) a holistic perspective in planning and organizing project-based group communications, (2) establishing and sustaining a continuous venue for communication, and (3) taking advantage of meetings and introducing the meeting-flow (MF) concept to facilitate the macro-level planning of communication and its venue.
Determination of Capsaicin Induced Increase in Dermal Blood Flow Using Laser Doppler Flowmetry Technique

In the present study, we evaluated laser Doppler flowmetry technique using LDF100C (Biopac systems) by determining blood flow changes following acute application of capsaicin on 12 healthy human subjects. Capsaicin applied locally (topical application) at a dose of 0.075% produced significant increase in mean dermal blood flow from 31.4 ± 3.1 Blood Perfusion Units (BPU) to 115. 7 ± 24.6 Blood Perfusion Units (BPU) after 30 minutes, also there was significant difference in dermal blood flow change between placebo (32.1 ± 2.7 BPU) and capsaicin (115.7 ± 24.6 BPU) applica- tion. Capsaicin application produced significant percentage change in dermal blood flow by 291.0 ± 85.3% from baseline, while the change was insignificant with placebo (13.2 ± 7.4%). Therefore, it is suggested that this technique which is technically sound, non-invasive and inexpensive can be adopted in various fields of research to determine blood flow changes and this technique can also be utilized to determine the antagonists of the mediators involved in capsaicin induced vasodilatation.
Femtosecond Laser Assisted Cataract Surgery after Deep Lamellar Keratoplasty: Case Report

Purpose: To report 2 cases that underwent deep anterior lamellar keratoplasty (DALK) and developed visually significant cataract and subsequently underwent femtosecond laser assisted cataract surgery (FLACS). Methods: Both patients underwent FLACS with implantation of toric intraocular lens (IOL) for correction of postkeratoplasty astigmatism. Capsulorrhexis was performed with the femtosecond laser; the nucleus was fragmented and aspirated. Three corneal incisions were performed with the femtosecond laser. In the second case, the angle of the side ports was changed to create a more vertical incision.Results: The preoperative endothelial cell count (ECC) was 1943 and 2446 cells/mm3 for the 1st and 2nd cases respectively and, 1860 and 2356 cell/mm3 for the 1st and 2nd cases postoperatively. At 6 months postoperatively, uncorrected distance visual acuity was 20/30 and 20/20 for the 1st and 2nd cases respectively.Conclusion: Femtolaser treatment of the crystalline lens may increase safety of the surgery in patients underwent deep anterior lamellar keratoplasty (DALK).
GEOBS: TOWARDS AN OBSERVATORY PROTOTYPE OF THE CONTENTS OF THE 65 FRENCH SDIS

In this context, the French research program “GEOBS: Spatial Data Infrastructure in the informational governance for environment” (2015-2018) led by the French National Centre for Scientific Research (CNRS) considers SDI as a real object of study for a better understanding of the flows of environmental information. For this purpose, we are developing a prototype observatory based on content and uses indicators of French SDIs. These indicators propose some (spatial, temporal, thematic, organisational) markers to analyse currently accessible spatial data assets as well as related territorial and informational restructuring.