Miracle-dz/UniFAR-FTUs huggingface dataset:
p-Adic Stability In Linear Algebra

Using the differential precision methods developed previously by the same authors, we study the p-adic stability of standard operations on matrices and vector spaces. We demonstrate that lattice-based methods surpass naive methods in many applications, such as matrix multiplication and sums and intersections of subspaces. We also analyze determinants, characteristic polynomials and LU factorization using these differential methods. We supplement our observations with numerical experiments.
A Package Generation and Recommendation Framework Based on Travelogues

Tourism has become the world's largest economy industry. More and more people share their travelogues on travel websites. Recommender system is an effective tool to provide travel services (e.g., Landscapes selection) for tourists. Many recommender systems are based on travel data that are supplied by travel agencies, and provide travel packages from a fixed package set, which bring two challenges for travel package recommender system. One is how to generate more travel packages. The other is how to measure more fine-grained user similarity. To address these challenges, we develop a package generation and recommendation framework to help travelers select landscapes. Firstly, we propose a Fuzzy Clustering based Package Generation algorithm (FCPG) to generate new travel packages to improve the overall recommendation effectiveness. Then, we develop a Dual Topic Model based Package Recommendation algorithm (DTMPR). It considers two user-related topics (travel seasons and areas), and provides more fine-grained user similarity measure. Experimental results show the superiority of our framework in comparison with the state-of-the-art methods.
Longitudinal Association Between Brain Amyloid-Beta and Gait in the Mayo Clinic Study of Aging

Background The longitudinal association between cerebral amyloid-beta (Aβ) and change in gait, and whether this association is mediated by cortical thickness, has yet to be determined. Methods We included 439 clinically normal (CN) participants, aged 50-69 years and enrolled in the Mayo Clinic Study of Aging with cerebral Aβ, cortical thickness, and gait measurements. Cerebral Aβ deposition was assessed by Pittsburgh Compound B (PiB)-PET in multiple regions of interest (ROIs) (ie, frontal, orbitofrontal, parietal, temporal, anterior cingulate, posterior cingulate/precuneus, and motor). Cortical thickness was assessed on 3T MRI in corresponding ROIs. Gait parameters (gait speed, cadence, stride length, double support time, and covariance of stance time) were measured with GAITRite. Multivariate-adjusted two level structural equation models were used to examine the longitudinal association between PiB-PET, cortical thickness, and change in gait over a median 15.6 months. Results Higher PiB-PET in all ROIs was associated with decreasing cadence and increasing double support time, and in the temporal ROI was associated with declining gait speed. In sex-stratified analyses, higher PiB-PET in all ROIs was associated with declining performance on all gait parameters among women. In contrast, among men, the only association was with higher orbitofrontal ROI PiB-PET and declining cadence. None of the associations were mediated by cortical thickness or attenuated after adjustment of baseline cognition. Conclusion Higher PiB-PET was associated with declining gait, particularly among women in this middle-aged CN cohort, independent of cortical thickness and baseline cognitive. Elevated brain Aβ may play a critical role in age-related mobility decline.
Effectiveness of Virtual Reality in Children With Cerebral Palsy: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Background Researchers recently investigated the effectiveness of virtual reality (VR) in helping children with cerebral palsy (CP) to improve motor function. A systematic review of randomized controlled trials (RCTs) using a meta‐analytic method to examine the effectiveness of VR in children with CP was thus needed. Purpose The purpose of this study was to update the current evidence about VR by systematically examining the research literature. Data Sources A systematic literature search of PubMed, CINAHL, Cochrane Central Register of Controlled Trials, ERIC, PsycINFO, and Web of Science up to December 2016 was conducted. Study Selection Studies with an RCT design, children with CP, comparisons of VR with other interventions, and movement‐related outcomes were included. Data Extraction A template was created to systematically code the demographic, methodological, and miscellaneous variables of each RCT. The Physiotherapy Evidence Database (PEDro) scale was used to evaluate the study quality. Effect size was computed and combined using meta‐analysis software. Moderator analyses were also used to explain the heterogeneity of the effect sizes in all RCTs. Data Synthesis . The literature search yielded 19 RCT studies with fair to good methodological quality. Overall, VR provided a large effect size (d = 0.861) when compared with other interventions. A large effect of VR on arm function (d = 0.835) and postural control (d = 1.003) and a medium effect on ambulation (d = 0.755) were also found. Only the VR type affected the overall VR effect: an engineer‐built system was more effective than a commercial system. Limitations The RCTs included in this study were of fair to good quality, had a high level of heterogeneity and small sample sizes, and used various intervention protocols. Conclusions Then compared with other interventions, VR seems to be an effective intervention for improving motor function in children with CP.
Two-Stage Constant-Envelope Precoding for Low-Cost Massive MIMO Systems

Massive MIMO is a key technology to meet increasing capacity demands in 5G wireless systems. However, a base station (BS) equipped with M ≫ 1 antennas requires M radio frequency (RF) chains with linear power amplifiers, which are very expensive. In this paper, we propose a two stage constant-envelope (CE) precoding scheme to enable low-cost implementation of massive MIMO BS with S ≪ M RF chains and nonlinear power amplifiers. Specifically, the MIMO precoder at the BS is partitioned into an RF precoder and a baseband precoder. The RF precoder is adaptive to the slow timescale channel statistics to achieve the array gain. The baseband precoder is adaptive to the fast timescale low dimensional effective channel to achieve the spatial multiplexing gain. Both the RF and baseband precoders are subject to CE constraints to reduce the implementation cost and the peak-to-average power ratio of the transmit signal. The two stage CE precoding is a challenging non-convex stochastic optimization problem and we propose an online alternating optimization algorithm which can autonomously converge to a stationary solution without explicit knowledge of channel statistics. Simulations show that the proposed solution has many advantages over various baselines.
Prevention of peritoneal recurrence in high‐risk colorectal cancer and evidence of T4 status as a potential risk factor

Peritoneal metastasis (PM) following primary resection of colorectal cancer is common. The combined use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy has significantly improved the survival outcome of patients with colorectal PM (CRPM). Diagnosing and treating early PM is essential as its extent is correlated with poorer outcomes. There are two novel therapies – second‐look surgery and synchronous hyperthermic intraperitoneal chemotherapy – that are proposed to prophylactically treat or intervene early in the disease process to reduce the incidence and adverse outcomes associated with PM. These strategies are limited to patients at high risk of developing CRPM, including those that had synchronous PM or ovarian metastases resected at primary tumour removal, or a perforated primary tumour. The data on advanced primary tumour (T4) as a prognostic factor for PM after primary resection suggest that T4a tumours are prognostically worse than T4b. This literature review outlines the evidence, feasibility and safety regarding the pre‐emptive treatments, as well as the relevance of T4a tumours as a risk factor for metachronous CRPM.
Long Noncoding RNA-Associated Transcriptomic Changes in Resiliency or Susceptibility to Depression and Response to Antidepressant Treatment

Abstract Background Recent emergence of long noncoding RNAs in regulating gene expression and thereby modulating physiological functions in brain has manifested their possible role in psychiatric disorders. In this study, the roles of long noncoding RNAs in susceptibility and resiliency to develop stress-induced depression and their response to antidepressant treatment were examined. Methods Microarray-based transcriptome-wide changes in long noncoding RNAs were determined in hippocampus of male Holtzman rats who showed susceptibility (learned helplessness) or resiliency (nonlearned helplessness) to develop depression. Changes in long noncoding RNA expression were also ascertained after subchronic administration of fluoxetine to learned helplessness rats. Bioinformatic and target prediction analyses (cis- and trans-acting) and qPCR-based assays were performed to decipher the functional role of altered long noncoding RNAs. Results Group-wise comparison showed an overrepresented class of long noncoding RNAs that were uniquely associated with nonlearned helplessness or learned helplessness behavior. Chromosomal mapping within the 5-kbp flank region of the top 20 dysregulated long noncoding RNAs in the learned helplessness group showed several target genes that were regulated through cis- or trans-actions, including Zbtb20 and Zfp385b from zinc finger binding protein family. Genomic context of differentially expressed long noncoding RNAs showed an overall blunted response in the learned helplessness group regardless of the long noncoding RNA classes analyzed. Gene ontology exhibited the functional clustering for anatomical structure development, cellular architecture modulation, protein metabolism, and cellular communications. Fluoxetine treatment reversed learned helplessness-induced changes in many long noncoding RNAs and target genes. Conclusions The involvement of specific classes of long noncoding RNAs with distinctive roles in modulating target gene expression could confer the role of long noncoding RNAs in resiliency or susceptibility to develop depression with a reciprocal response to antidepressant treatment.
Learning social affordance grammar from videos: Transferring human interactions to human-robot interactions

In this paper, we present a general framework for learning social affordance grammar as a spatiotemporal AND-OR graph (ST-AOG) from RGB-D videos of human interactions, and transfer the grammar to humanoids to enable a real-time motion inference for human-robot interaction (HRI). Based on Gibbs sampling, our weakly supervised grammar learning can automatically construct a hierarchical representation of an interaction with long-term joint sub-tasks of both agents and short term atomic actions of individual agents. Based on a new RGB-D video dataset with rich instances of human interactions, our experiments of Baxter simulation, human evaluation, and real Baxter test demonstrate that the model learned from limited training data successfully generates human-like behaviors in unseen scenarios and outperforms both baselines.
MRUniNovo: an efficient tool for de novo peptide sequencing utilizing the hadoop distributed computing framework

Summary: Tandem mass spectrometry‐based de novo peptide sequencing is a complex and time‐consuming process. The current algorithms for de novo peptide sequencing cannot rapidly and thoroughly process large mass spectrometry datasets. In this paper, we propose MRUniNovo, a novel tool for parallel de novo peptide sequencing. MRUniNovo parallelizes UniNovo based on the Hadoop compute platform. Our experimental results demonstrate that MRUniNovo significantly reduces the computation time of de novo peptide sequencing without sacrificing the correctness and accuracy of the results, and thus can process very large datasets that UniNovo cannot. Availability and Implementation: MRUniNovo is an open source software tool implemented in java. The source code and the parameter settings are available at http://bioinfo.hupo. org.cn/MRUniNovo/index.php Contact: s131020002@hnu.edu. cn; taochen1019@163.com Supplementary information: Supplementary data are available at Bioinformatics online.
Clinical study of the time of repeated computed tomography and replanning for patients with nasopharyngeal carcinoma

Purpose To study the necessity of repeat computed tomography (CT) scan and replanning and know a more accurate time using weekly kilovoltage cone beam computed tomography (kV-CBCT) scans for patients with nasopharyngeal carcinoma (NPC) during radiotherapy. Methods and Materials Thirteen NPC patients treated with IMRT were enrolled into this prospective study. Weekly pretreatment kV-CBCT scans were performed on the 1st, 6th, 11st, 16th, 21st and 26th radiation time, respectively. Target delineations were contoured on all fractionated CBCT images, including the gross tumor volume of the primary nasopharyngeal tumor (GTVnx) and parotid glands. The volumes of GTVnx and parotid glands were calculated automatically using the Pinnacle3 8.0 system. Compared to the original GTVnx, the percentage of shrinking volume (ΔP) ≥ 50% was considered significantly. Results As the radiation proceeding, the GTVnx had a trend of shrinkage. Of all 13 patients, 11 cases (84.6%) had the volume shrinking ≥ 50% before the 21st radiation and 12 cases (92.3%) before the 26th radiation. And the parotid volume decreased significantly in the first four-week radiation, 6.45 ± 3.16cm3 (range, 3.06-13.9cm3) for the left parotid gland and 5.78 ± 2.39cm3 (range, 2.70-11.2cm3) for the right. Furthermore, only a little displacement occurred to bilateral parotid glands. Conclusion The replanning for NPC patients with IMRT is necessary, and the time between the 21st to 25th radiations is appropriate.
Biological basis for human capacitation—revisited

BACKGROUND A little more than a decade ago a review entitled 'Biological basis for human capacitation' was published. A primary conclusion of the review was that with all the technological advances that have been made since the first experiments demonstrated the in vivo requirement of capacitation for fertilization, very little progress had since been made, most significantly for human. OBJECTIVE AND RATIONALE The present review was carried out to provide an update on the biological basis for human capacitation. It briefly revisits the original schema, presents a review of the literature that urged research interest in human sperm capacitation and puts under the spotlight the original definition of capacitation balanced against the limitations of experiments in vitro to characterize a complex process that necessarily mandates a female component, and very recent findings in the mouse. It also includes proposed considerations for new thinking regarding capacitation, and progress toward understanding the biology of human capacitation. SEARCH METHODS The PubMed, Google Scholar and Scopus literature databases were reviewed extensively using inclusive, broad and multispecies search terms without publication date limitation. OUTCOMES Comprehensive screening of the literature database showed that no papers regarding human sperm capacitation in vivo have been published in the past 20 years. Recent experiments in the mouse have provided compelling and unanticipated data regarding capacitation and in vivo fertilization. Questions were posed and addressed regarding: stimuli for initiation of capacitation, capacitation relative to the cumulus-oocyte complex, comparison between in vivo and in vitro capacitation, and potential species-specific differences in location and timing of capacitation. WIDER IMPLICATIONS There has been no progress on the in vivo biology of human sperm capacitation since before the turn of the century. Human IVF and its technologies may likely have inhibited, and continue to hold back, any future in vivo experiments that would address one or more questions regarding acquisition of fertilizing capacity in human. The limiting factor for progress in the area is access to funding and human subjects.
Increased expression of ZEB1-AS1 correlates with higher histopathological grade and promotes tumorigenesis in bladder cancer

Bladder cancer is one of the most common urinary cancers worldwide. Emerging studies indicated that long non-coding RNAs (lncRNAs) play crucial roles in cancer biology. In this study, we found that a novel lncRNA Zinc finger E-box-binding homeebox1 (ZEB1) antisense RNA (ZEB1-AS1) was overexpressed in bladder cancer tissues compared to paired noncancerous tissues. Moreover, the expression of ZEB1-AS1 was positive correlated with higher histological grade and TNM stage in bladder cancer. Furthermore, Loss-of-function experiments showed that down-regulation of ZEB1-AS1 not only can suppress cell growth but also can inhibit migration and induce apoptosis in bladder cancer cell lines 5637 and SW780. In conclusion, these findings indicated that ZEB1-AS1 plays regulatory roles in bladder cancer and it may become a novel molecular biomarker of prognosis and therapy in bladder cancer.
Does Bank Ownership Imply Efficient Monitoring? Evidence from Bank Lending and Firm Investment Efficiencies in China

This study investigates the effect of bank ownership on lending and firm investment efficiencies to give reasons for the mixed evidence that exists on the impact of bank ownership on firm performance. Using China’s listed firms as an example, we find that bank ownership reduces the efficiency of bank lending and harms investment efficiency for state-owned enterprises (SOEs), while simultaneously relating to optimal lending decisions and enhanced investment efficiency for non-SOEs. Our findings suggest that banks monitor non-SOEs effectively, but are less effective at monitoring SOEs. We document that banks’ ex post monitoring on non-SOEs’ investment policy results from their more effective ex ante monitoring of their lending decisions. Further analysis suggests that bank ownership hurts firm performance for SOEs while enhancing firm performance for non-SOEs. Overall, we document that in an emerging market where SOEs and non-SOEs co-exist, bank ownership affects firm performance by influencing the lending decision and firm investment policy, while the effectiveness of their monitoring varies with the firm’s ownership structure.
Co-Creation and User Involvement in a Living Lab : An Evaluation of Applied Methods

Living labs are only recently developing to facilitate active user involvement in an interactive setting. Research on the methodological facilitation of co-creation and user feedback in such open physical spaces is still scarce. The objectives of this paper are to identify applied methods as well as to investigate the level of user involvement in living labs to further develop theoretical insights on living labs as well as on method implementations for co-creation. A qualitative explorative approach in the form of a case study on the living lab JOSEPHS in Nuremberg is applied. This paper finds that applied methods serve either of two purposes: 1) Collecting data for innovation research, or 2) adapting co-creation to living labs. Combined accordingly, methods cover both purposes and increase user involvement. Furthermore, six factors that determine user involvement are proposed. Implications for living lab managers are provided.
Assessing joint destruction in the knees of patients with rheumatoid arthritis by using a semi-automated software for magnetic resonance imaging: therapeutic effect of methotrexate plus etanercept compared with methotrexate monotherapy

Abstract Objectives: To evaluate the prevention of knee joint destruction and clinical efficacy of methotrexate (MTX) plus etanercept (ETN) compared with MTX monotherapy in patients with rheumatoid arthritis (RA) by using semi-automated software for magnetic resonance imaging (MRI) scan analysis. Materials and methods: This study enrolled patients with active moderate-to-severe RA who displayed an inadequate response to oral MTX at screening. Patients were assigned to receive either MTX plus ETN or MTX monotherapy (≥10 mg/week). The primary endpoint was the quantitative knee cartilage volume using our software developed for MRI scan analysis. Results: A total of 18 female patients were enrolled in this study and allocated to the MTX + ETN group (n = 9) or the MTX monotherapy group (n = 9). At 52 weeks, the quantitative knee cartilage volume was significantly reduced compared with baseline in both groups (MTX plus ETN group: 2.3 ± 2.3 cm3; MTX monotherapy group: 2.4 ± 1.6 cm3); however, the difference was not significant. Conclusion: The semi-automated software for MRI scan analysis can reveal useful and potentially clinically important information about the characteristics of knee joint destruction in patients with RA.
CDX2 prognostic value in stage II/III resected colon cancer is related to CMS classification

Background Caudal-type homeobox transcription factor 2 (CDX2) is involved in colon cancer (CC) oncogenesis and has been proposed as a prognostic biomarker in patients with stage II or III CC. Patients and methods We analyzed CDX2 expression in a series of 469 CC typed for the new international consensus molecular subtype (CMS) classification, and we confirmed results in a series of 90 CC. Results Here, we show that lack of CDX2 expression is only present in the mesenchymal subgroup (CMS4) and in MSI-immune tumors (CMS1) and not in CMS2 and CMS3 colon cancer. Although CDX2 expression was a globally independent prognostic factor, loss of CDX2 expression is not associated with a worse prognosis in the CMS1 group, but is highly prognostic in CMS4 patients for both relapse free and overall survival. Similarly, lack of CDX2 expression was a bad prognostic factor in MSS patients, but not in MSI. Conclusions Our work suggests that combination of the consensual CMS classification and lack of CDX2 expression could be a useful marker to identify CMS4/CDX2-negative patients with a very poor prognosis.