Miracle-dz/UniFAR-FTUs huggingface dataset:
TRECVID 2006 Rushes Exploitation by CAS MCG

In our rushes exploitation task of TRECVID 2006, we propose a novel and interactive rushes video selection and editing method based on hierarchical browsing of key frames, where high level features of each key frame such as face, interview, person, crowd, building, outdoor, waterbody, and other information about redundancy and repetition are displayed at same time for helping editors to select what they really want. During high level feature extraction, we propose a multi-modal interview detection method based on audio classification and face detection, and a new repetition detection method based on spatio-temporal slice. We also detect some concepts such as crowd, building, outdoor, waterbody based on SVM classifiers. Additionally, we characterize rushes by categorization camera motion for inferring intention. Due to the difficulty of high level feature extraction and the diversity of editor’s requirements, our hierarchical browsing method along with extracted information may be a good choice for rushes exploitation.
Activation of cellular cytotoxicity and complement-mediated lysis of melanoma and neuroblastoma cells in vitro by murine antiganglioside antibodies MB 3.6 and 14.G2a

Mouse monoclonal antibodies against tumour-associated gangliosides G02 (14.G2a) and G03 (MB 3.6) were tested to mediate antibody-dependent cellular cytotoxicity (ADCC) with various effector cells or complement-dependent cytolysis (CDC). We also evaluated the immunomodulating potential of interferons in combination with cellular cytotoxicity. Using effector: target (E/T) ratios of 40: 1, ADCC with effector cells such as granulocytes or mononuclear blood cells was not detectable against melanoma cell lines GR, SK-MEL-28 and G- 361 which preferentially express G03and bind antibody MB 3.6. Neuroblastoma cell line SK-N-LO, which was used for comparative purposes, mainly expressed G02 and the tumour cells were killed effectively after labelling with antibody 14.G2a. Granulocytes did not show significant killing of melanoma cells by ADCC, but neuroblastoma cells were killed very efficiently. Peripheral blood mononuclear cells (PBMC) also failed to kill melanoma cells. Interferon-fS slightly stimulated PBMC and increased killing of neuroblastoma cells, but no additive effects with ADCC were detectable. Incubation of target cells with interferons produced no significant differences in susceptibility of the target cells to interferon-activated PBMC cytotoxicity. Despite the lack of effectiveness in mediating cellular cytotoxicity, G03antibody MB 3.6 showed strong complement- dependent cytolysis in the presence of human plasma. There were remarkable differences in individual activity and different susceptibility of the melanoma cell lines. We assume that CDC may have more activity against melanoma cells than cytotoxicity associated with various effector cells
Phase Noise Analysis of the Tuned-Input–Tuned-Output (TITO) Oscillator

The theoretical phase noise performance of a tuned-input tuned-output (TITO) oscillator is analyzed with a rigorous approach, which yields a compact closed-form phase noise equation that is dependent only on the value of the circuit components and current consumption of the oscillator. A straightforward comparison with the more commonly used differential LC-tank oscillator shows that the latter is in fact superior to the TITO oscillator, at least if the oscillator behavior is not too distant from the ideal behavior considered in the analysis. Phase noise simulations match admirably the theoretical results.
Demonstration of a second ligand for the low affinity receptor for immunoglobulin E (CD23) using recombinant CD23 reconstituted into fluorescent liposomes

Recombinant full-length human CD23 has been incorporated into fluorescent liposomes to demonstrate the existence of a ligand for CD23 that is different from the previously known ligand, immunoglobulin E (IgE). The novel ligand for CD23 is expressed on subsets of normal T cells and B cells as well as on some myeloma cell lines. The interaction of full-length CD23 with its ligand is specifically inhibited by anti-CD23 monoclonal antibodies and by IgE, and it is Ca2+ dependent. Moreover, tunicamycin treatment of a CD23-binding cell line, RPMI 8226, significantly reduced the binding of CD23 incorporated into fluorescent liposomes, and a sugar, fucose-1-phosphate, was found to inhibit CD23-liposome binding to RPMI 8226 cells, suggesting the contribution of sugar structures on the CD23 ligand. In addition, CD23- transfected COS cells were shown to form specific conjugates with the cell line RPMI 8226. These data demonstrate that CD23 interacts with a ligand, which is different from IgE, and that CD23 can be considered as a new surface adhesion molecule involved in cell-cell interactions.
Sulfate Formation in Sea-Salt Aerosols: Constraints from Oxygen Isotopes

imparts a large D 17 O signature to the resulting sulfate (8.8%) relative to oxidation by H2O2 (0.9% )o r by OH or O 2 (0%). Ship data from two Indian Ocean Experiment (INDOEX) cruises in the Indian Ocean indicate D 17 O values usually 70%) and increases MBL sulfate concentrations by typically >10% (up to 30%). Globally, this mechanism contributes 9% of atmospheric sulfate production and 1% of the sulfate burden. The impact on H2SO4 (g) formation and implications for the potential formation of new particles in the MBL warrants inclusion in models examining the radiative effects of sulfate aerosols.
The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection

ABSTRACT TGFβ-ALK5 pro-fibrotic signalling and herpesvirus infections have been implicated in the pathogenesis and exacerbation of pulmonary fibrosis. In this study we addressed the role of TGFβ-ALK5 signalling during the progression of fibrosis in a two-hit mouse model of murine γ-herpesvirus 68 (MHV-68) infection on the background of pre-existing bleomycin-induced pulmonary fibrosis. Assessment of total lung collagen levels in combination with ex vivo micro-computed tomography (µCT) analysis of whole lungs demonstrated that MHV-68 infection did not enhance lung collagen deposition in this two-hit model but led to a persistent and exacerbated inflammatory response. Moreover, µCT reconstruction and analysis of the two-hit model revealed distinguishing features of diffuse ground-glass opacities and consolidation superimposed on pre-existing fibrosis that were reminiscent of those observed in acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). Virally-infected murine fibrotic lungs further displayed evidence of extensive inflammatory cell infiltration and increased levels of CCL2, TNFα, IL-1β and IL-10. Blockade of TGFβ-ALK5 signalling attenuated lung collagen accumulation in bleomycin-alone injured mice, but this anti-fibrotic effect was reduced in the presence of concomitant viral infection. In contrast, inhibition of TGFβ-ALK5 signalling in virally-infected fibrotic lungs was associated with reduced inflammatory cell aggregates and increased levels of the antiviral cytokine IFNγ. These data reveal newly identified intricacies for the TGFβ-ALK5 signalling axis in experimental lung fibrosis, with different outcomes in response to ALK5 inhibition depending on the presence of viral infection. These findings raise important considerations for the targeting of TGFβ signalling responses in the context of pulmonary fibrosis. Summary: This article describes newly identified intricacies for the TGFβ-ALK5 signalling axis in experimental lung fibrosis and reports different outcomes in response to ALK5 inhibition depending on the presence of viral infection. These findings raise important considerations for the future targeting of TGFβ signalling responses in the context of pulmonary fibrosis.
An Empirical Study Of The Mediating Mechanisms of Knowledge Contribution

Knowledge contribution is critical to the success of Knowledge Management (KM) initiatives. While extensive research has been done to understand how different individual and organizational factors affect knowledge contribution behavior, few have studied the mediating mechanisms affecting the contribution act. This study develops and empirically validates a model of how people contribute their knowledge in the distributed team environment. Particularly, we explore two mediating mechanisms of awareness and effort required in searching and matching. Our results indicate that the mediating mechanisms model provides a better specification of the antecedents of contribution behavior. Our findings and implications are discussed in the paper.
Use of microgravity bioreactors for development of an in vitro rat salivary gland cell culture model

During development, salivary gland (SG) cells both secrete factors which modulate cellular behavior and express specific hormone receptors. Whether SG cell growth is modulated by an autocrine epidermal growth factor (EGF) receptor‐mediated signal transduction pathway is not clearly understood. SG tissue is the synthesis site for functionally distinct products including growth factors, digestive enzymes, and homeostasis maintaining factors. Historically, SG cells have proven difficult to grow and may be only maintained as limited three‐dimensional ductal‐type structures in collagen gels or on reconstituted basement membrane gels. A novel approach to establishing primary rat SG cultures is use of microgravity bioreactors originally designed by NASA as low‐shear culture systems for predicting cell growth and differentiation in the microgravity environment of space. These completely fluid‐filled bioreactors, which are oriented horizontally and rotate, have proven advantageous for Earth‐based culture of three‐dimensional cell assemblies, tissue‐like aggregates, and glandular structures. Use of microgravity bioreactors for establishing in vitro models to investigate steroid‐mediated secretion of EGF by normal SG cells may also prove useful for the investigation of cancer and other salivary gland disorders. These microgravity bioreactors promise challenging opportunities for future applications in basic and applied cell research. © 1993 Wiley‐Liss, Inc.
Imported Chikungunya Virus Strains, Taiwan, 2006–2014

We identified 78 imported chikungunya cases in Taiwan during 2006–2014. Sixty-six (84.6%) cases were initially suspected to be dengue, which indicates the necessity for laboratory diagnostics in differentiation between dengue and chikungunya. Results also emphasize the need for active surveillance of febrile illness at points of entry.
An Modified EPQ Model with Deteriorating Production System and Deteriorating Product

The proposed study considers both product deterioration and production process deterioration in a traditional Economical Production Quantity model. In this model, backlog and rework process are also taken into consideration while the production process is assumed to be imperfect. Unserviceable products will be manufactured as a result. Unserviceable products are kept in storage until the end of the normal production run and then reworked to condition that can meet the standard of customer requirement. The production quality is also assumed to be deteriorative. The production process is assumed to be in control when the production run starts and the defective rate is relatively. At a certain point, the deterioration and switch of states occurs and the defective rate increases to a higher value. After the normal production cycle, the state of machine will be restored in control state. The overall objective of this study is to minimize the expected total cost by determining the combination of total production quantity and backlog quantity.
Divergent Perceptions: Parental Acceptance and Adolescents' Psychosocial Adjustment.

This study examined whether divergent parent-adolescent perceptions regarding parental acceptance predicted adolescent adjustment when the level of parental acceptance (as perceived by the adolescent) was held constant, a methodological and theoretical issue largely ignored by previous research. Subjects were 192 intact, primarily dual-earner families consisting of mothers, fathers, and two adolescent siblings (firstborn children were in 8th, 9th, or 10th grade and had siblings 1 to 4 years younger) . The families completed home and telephone interviews regarding adolescent and family functioning. Results of hierarchical regression analyses of their responses suggested that divergent parent-adolescent perceptions of parental acceptance did not predict adolescent adjustment over and above the level of acceptance. The findings suggested that previous research needs to be examined more critically, for they seriously question the interpretability of divergent perceptions when level of acceptance is ignored. (Contains 13 references.) (Author/KB) ******************************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. ******************************************************************************** U.S. DEPARTMENT OF EDUCATION Office of Educational Research and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) This document has been reproduced as received from the person or organization originating it. 0 Minor changes have been made to improve reproduction quality. Points of view or opinions stated in this document do not necessarily represent official OERI position or policy. DIVERGENT PERCEPTIONS: PARENTAL ACCEPTANCE AND ADOLESCENTS' PSYCHOSOCIAL ADJUSTMENT Maria E. Eguia Brown University / Bradley Hospital Department of Psychiatry and Human Behavior Poster presented at the biannual meeting of the Society for Research in Child Development, Albuquerque, NM, April, 1999. PERMISSION TO REPRODUCE AND DISSEMINATE THIS MATERIAL HAS BEEN GRANTED BY
CeilingSee: Device-free occupancy inference through lighting infrastructure based LED sensing

As a key component of building management and security, occupancy inference through smart sensing has attracted a lot of research attentions for nearly two decades. Nevertheless, existing solutions mostly rely on either pre-deployed infrastructures or user device participation, thus hampering their wide adoption. This paper presents CeilingSee, a dedicated occupancy inference system free of heavy infrastructure deployments and user involvements. Building upon existing LED lighting systems, CeilingSee converts part of the ceiling-mounted LED luminaires to act as sensors, sensing the variances in diffuse reflection caused by occupants. In realizing CeilingSee, we first re-design the LED driver to leverage LED's photoelectric effect so as to transform a light emitter to a light sensor. In order to produce accurate occupancy inference, we then engineer efficient learning algorithms to fuse sensing information gathered by multiple LED luminaires. We build a testbed covering a 30m2 office area; extensive experiments show that CeilingSee is able to achieve very high accuracy in occupancy inference.
Enhanced exploration of oral history archives through processed video and synchronized text transcripts

A digital video library of over 900 hours of video and 18000 stories from The HistoryMakers was used by 266 students, faculty, librarians, and life-long learners interacting with a system providing multiple search and viewing capabilities over a trial period of several months. User demographics and actions were logged with this multimedia collection, providing quantitative and qualitative metrics on system use. These transaction logs were complemented with heuristic evaluation, interviews, and contextual inquiry with representative users. Collectively, these mixed methods informed the development of the next generation web-based interface for the HistoryMakers video oral histories to improve access to and dissemination of this rich cultural resource. In particular, the feature of a synchronized text transcript in the video player for the narratives merited further investigation. Such an interface has not seen widespread use in digital video players available on the web, yet was valued highly by oral history archive viewers. A user study with 27 participants measured the utility of the HistoryMakers web interface incorporating the synchronized transcript video player for stated fact-finding and open-ended tasks. For life oral histories, an aligned text transcript is valued for both tasks, with the video rated significantly more useful for open-ended tasks over fact-finding. These results suggest a task-dependent role of modality in presentation of oral histories, with synchronized transcripts rated highly across tasks.
Brownian dynamics without Green's functions.

We develop a Fluctuating Immersed Boundary (FIB) method for performing Brownian dynamics simulations of confined particle suspensions. Unlike traditional methods which employ analytical Green's functions for Stokes flow in the confined geometry, the FIB method uses a fluctuating finite-volume Stokes solver to generate the action of the response functions "on the fly. " Importantly, we demonstrate that both the deterministic terms necessary to capture the hydrodynamic interactions among the suspended particles, as well as the stochastic terms necessary to generate the hydrodynamically correlated Brownian motion, can be generated by solving the steady Stokes equations numerically only once per time step. This is accomplished by including a stochastic contribution to the stress tensor in the fluid equations consistent with fluctuating hydrodynamics. We develop novel temporal integrators that account for the multiplicative nature of the noise in the equations of Brownian dynamics and the strong dependence of the mobility on the configuration for confined systems. Notably, we propose a random finite difference approach to approximating the stochastic drift proportional to the divergence of the configuration-dependent mobility matrix. Through comparisons with analytical and existing computational results, we numerically demonstrate the ability of the FIB method to accurately capture both the static (equilibrium) and dynamic properties of interacting particles in flow.
Argumentation and Explanation in Conceptual Change: Indications From Protocol Analyses of Peer-to-Peer Dialog

In this paper we attempt to identify which peer collaboration characteristics may be accountable for conceptual change through interaction. We focus on different socio-cognitive aspects of the peer dialog and relate these with learning gains on the dyadic as well as the individual level. The scientific topic that was used for this study concerns natural selection, a topic for which students' intuitive conceptions have been shown to be particularly robust. Learning tasks were designed according to the socio-cognitive conflict instructional paradigm. After receiving a short instructional intervention on natural selection, paired students were asked to collaboratively construct explanations for certain evolutionary phenomena while engaging in dialectical argumentation. Two quantitative coding schemes were developed, each with a different granularity. The first assessed discrete dialog moves that pertained to dialectical argumentation and to consensual explanation development. The second scheme characterized the dialog as a whole on a number of socio-cognitive dimensions. Results from analyses on the dyadic as well as the individual level revealed that the engagement in dialectical argumentation predicted conceptual learning gains, whereas consensual explanation development did not. These findings open up new venues for research on the mechanisms of learning in and from peer collaboration.
Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

Recombinant adenovirus serotype 5 (Ad5) vectors represent one of the most efficient gene delivery vectors in life sciences. However, Ad5 is dependent on expression of the coxsackievirus-adenovirus-receptor (CAR) on the surface of target cell for efficient transduction, which limits it’s utility for certain cell types. Herein we present a new vector, Ad5PTDf35, which is an Ad5 vector having serotype 35 fiber-specificity and Tat-PTD hexon-modification. This vector shows dramatically increased transduction capacity of primary human cell cultures including T cells, monocytes, macrophages, dendritic cells, pancreatic islets and exocrine cells, mesenchymal stem cells and tumor initiating cells. Biodistribution in mice following systemic administration (tail-vein injection) show significantly reduced uptake in the liver and spleen of Ad5PTDf35 compared to unmodified Ad5. Therefore, replication-competent viruses with these modifications may be further developed as oncolytic agents for cancer therapy. User-friendly backbone plasmids containing these modifications were developed for compatibility to the AdEasy-system to facilitate the development of surface-modified adenoviruses for gene delivery to difficult-to-transduce cells in basic, pre-clinical and clinical research.
Difficulty Identifying Feelings and Automatic Activation in the Fusiform Gyrus in Response to Facial Emotion

Difficulties in identifying and differentiating one's emotions are a central characteristic of alexithymia. In the present study, automatic activation of the fusiform gyrus to facial emotion was investigated as a function of alexithymia as assessed by the 20-item Toronto Alexithymia Scale. During 3 Tesla fMRI scanning, pictures of faces bearing sad, happy, and neutral expressions masked by neutral faces were presented to 22 healthy adults who also responded to the Toronto Alexithymia Scale. The fusiform gyrus was selected as the region of interest, and voxel values of this region were extracted, summarized as means, and tested among the different conditions (sad, happy, and neutral faces). Masked sad facial emotions were associated with greater bilateral activation of the fusiform gyrus than masked neutral faces. The subscale, Difficulty Identifying Feelings, was negatively correlated with the neural response of the fusiform gyrus to masked sad faces. The correlation results suggest that automatic hyporesponsiveness of the fusiform gyrus to negative emotion stimuli may reflect problems in recognizing one's emotions in everyday life.
Comparative study of periodicity estimation methods using ultrasonic signals

Introduction Various signal-processing techniques have been proposed to extract quantitative information about internal structures of tissues from the original radio frequency (RF) signals instead of an ultrasound image. The quantifiable parameter called the mean scatterer spacing (MSS) can be useful to detect changes in the quasi-periodic microstructure of tissues such as the liver or the spleen, using ultrasonic signals. Methods We evaluate and compare the performance of three classic methods of spectral estimation to calculate the MSS without operator intervention: Tufts-Kumaresan, SAC (Spectral Autocorrelation) and MUSIC (MUltiple SIgnal Classification). Initially the evaluations were performed with 10,000 signals simulated from a model in which the variables of interest are controlled, and then, real signals from sponge phantoms were used. Results For the simulated signals, the performance of all three methods decreased with increasing Ad or jitter levels. For the sponges, none of the methods accurately estimated the pore size. Conclusion For the simulated signals, Tufts-Kumaresan had the lowest performance, whereas SAC and MUSIC had similar results. For sponges, only Tufts-Kumaresan was able to detect the increase in the size of the pores of the sponge, although most often, it estimated sizes larger than expected.