Miracle-dz/UniFAR-FTUs huggingface dataset:
Reducing Energy per Instruction via Dynamic Resource Allocation and Voltage and Frequency Adaptation in Asymmetric Multicores

With the advent of multicore processors the emphasis incomputation is moving from sequential to parallel processing. Still, applications that require strong sequential performance do not achieve their highest performance/power when executing on current multicoresystems. As the computational needs vary significantly across different applications and with time, there is a need to dynamically allocate appropriate computational resources on demand to suit the applications' current needs, in order to minimize the energy consumption. The Energy per Instruction (EPI) could be further decreased by dynamically adapting the voltage and frequency to better fit the changing characteristics of the workload. Not only can a core be forced to a low power mode when its activity level is low, but the power saved by doing so could be opportunistically re-budgeted to other cores to boost the overall system throughput. To this end, we propose a holistic solution to energy efficiency improvement by seamlessly combining heterogeneity, Dynamic ResourceAllocation (DRA) and Dynamic Voltage and Frequency Adaptation (DVFA) capabilities to adapt the core resources to the changing demands of applications. Our results show that the proposed scheme provides anEPI reduction of about 17.9% when compared to the baseline heterogeneous multicore, 14% when compared to the baseline heterogeneous multicore with DVFA only and about 16.5% when compared to the baseline heterogeneous multicore with DRA only.
Mouse Studies to Shape Clinical Trials for Mitochondrial Diseases: High Fat Diet in Harlequin Mice

Background Therapeutic options in human mitochondrial oxidative phosphorylation (OXPHOS) diseases have been poorly evaluated mostly because of the scarcity of cohorts and the inter-individual variability of disease progression. Thus, while a high fat diet (HFD) is often recommended, data regarding efficacy are limited. Our objectives were 1) to determine our ability to evaluate therapeutic options in the Harlequin OXPHOS complex I (CI)-deficient mice, in the context of a mitochondrial disease with human hallmarks and 2) to assess the effects of a HFD. Methods and Findings Before launching long and expensive animal studies, we showed that palmitate afforded long-term death-protection in 3 CI-mutant human fibroblasts cell lines. We next demonstrated that using the Harlequin mouse, it was possible to draw solid conclusions on the efficacy of a 5-month-HFD on neurodegenerative symptoms. Moreover, we could identify a group of highly responsive animals, echoing the high variability of the disease progression in Harlequin mice. Conclusions These results suggest that a reduced number of patients with identical genetic disease should be sufficient to reach firm conclusions as far as the potential existence of responders and non responders is recognized. They also positively prefigure HFD-trials in OXPHOS-deficient patients.
Determination of metabolic and heart rate responses of rats to treadmill exercise.

BROOKS, GEORGE A. , AND TIMOTHY P. WHITE. Determination of metabolic and heart rate responses of rats to treadmill exercise. J. Appl. Physiol. : Respirat. Environ. Exercise Physiol. 45(6): 1009-1015, 1978. -A rapid-flow, open-circuit, indirect calorimeter was developed and used to study metabolic rates of rats at rest and in response to three running speeds (14.3, 28.7, and 43.1 m/min) and five grades (1, 5, 10, 15, and 20%). Electrocardiogram connections were available within the apparatus for simultaneous determination of heart rate (f,>. Validity of the calorimeter was established by observing responses to the addition of mixed gases including 14C02, and by comparing oxygen consumptions when anesthetized rats were placed in the openor a closed-circuit system. Halfresponse time of the system was 27 t 3 s (mean t SE). With one rat in each system values for O2 consumption (Vo,) were 15.86 t 0.91 and 15.77 ~fr 0.90 ml/kg per min for the open and closed systems, respectively. Highest Vo,. values observed were 80.86 t 2.48 ml/kg per min for rats running at 43.1 m/ min on a 20% grade. The corresponding heart rates were 595 t 5 beats/min. Correlations between Vo, and running speed ranged from 0.83 on 1% and 15% grades, to 0.90 on a 10% grade. Correlations between frl and speed ranged from 0.70 on a 1% grade, to 0.79 on a 10% grade. Steady-rate values for Vo, and V@O~ were 51.1. and 45.3 ml/kg per min during running at 14.3 m/min on 1% grade, and 69.0 and 65.1 ml/kg per min during running at 28.7 m/min on 15% grade.
Regulatory gene networks and the properties of the developmental process

Genomic instructions for development are encoded in arrays of regulatory DNA. These specify large networks of interactions among genes producing transcription factors and signaling components. The architecture of such networks both explains and predicts developmental phenomenology. Although network analysis is yet in its early stages, some fundamental commonalities are already emerging. Two such are the use of multigenic feedback loops to ensure the progressivity of developmental regulatory states and the prevalence of repressive regulatory interactions in spatial control processes. Gene regulatory networks make it possible to explain the process of development in causal terms and eventually will enable the redesign of developmental regulatory circuitry to achieve different outcomes.
VISION GUIDED BY VEHICLE DYNAMICS FOR ONBOARD ESTIMATION OF THE VISIBILITY RANGE

Abstract The presence of an area with low visibility conditions is a relevant information to communicate to drivers before they reach this area. In this aim, we develop a generic sensor of visibility using an onboard camera in a vehicle equipped with vehicle-to-infrastructure (V2I) communications. Our approach consists in estimating the range to the most distant object belonging to the plane of the road having at least 5% of contrast. The originality of this approach lies in the fact that the depth map of the vehicle environment is obtained by aligning the road plane in successive images. This algorithm exploits the dynamics of the vehicle which is given or observed by proprioceptive sensors. In this paper, we present the principle of our approach in terms of image processing and explain how the vehicle dynamics takes part in it with a sensitivity study.
Dilatonic black holes in higher curvature string gravity.

We give analytical arguments and demonstrate numerically the existence of black hole solutions of the 4D effective superstring action in the presence of Gauss-Bonnet quadratic curvature terms. The solutions possess nontrivial dilaton hair. The hair, however, is of "secondary type," in the sense that the dilaton charge is expressed in terms of the black hole mass. Our solutions are not covered by the assumptions of existing proofs of the "no-hair" theorem. We also find some alternative solutions with singular metric behavior, but finite energy. The absence of naked singularities in this system is pointed out.
Students' Perceptions of the Goal Structure in Mathematics Classrooms: Relations with Goal Orientations, Mathematics Anxiety, and Help-Seeking Behavior

This study explores relations between students’ perceptions of the classroom goal structures, their personal goal orientations, mathematics anxiety, and help-seeking behavior in mathematics classes. The respondents were 309 Norwegian middle school students. The data were analyzed by means of structural equation modeling (SEM). The analyses revealed that a mastery goal orientation was associated with lower levels of anxiety and more use of help-seeking behavior whereas performance-avoidance orientation predicted higher levels of anxiety and less use of help-seeking behavior. We found no direct relation between goal structure and mathematics anxiety or help-seeking behavior. However, the perceived goal structure was indirectly related to these variables, mediated through personal goal orientation.
Comparison of Shams' test for rectal mucus to an immunological test for fecal occult blood in large intestinal carcinoma screening. Analysis of a check-up of 6480 asymptomatic subjects.

The sugar moiety detected from rectal mucus by the Galactose oxidase-schiff (Shams' test) is considered a substitutive test for immunological fecal occult blood test (FOBT) in screening colorectal carcinoma. Two strategies of screening were applied in 6480 subjects over 40 years of age, and 130 cm flexible colonoscope used for sigmoidoscopy or pancolonoscopy. Of them, 3820 were taken for immune FOBT (SPA test) and Shams' test. Only those who showed positive tests were chosen for 60 cm flexible sigmoidoscopy, while another 2660 subjects for both sigmoidoscopy and tests at the same time. Additionally, 130 cm flexible pancolonoscopy was carried out in 103 individuals with positive Shams' test for evaluating the false positive rate. Shams' test showed a sensitivity of 85.7% for colorectal cancer, 47.1% for adenomas in preselected patients, while the positive rate of SPA test were 90.5% and 41.2% respectively. In 3820 asymptomatic subjects undergoing sequential screening (aged 45 years and higher), Shams' test showed 9.1% positive, SPA showed 11.2% and 620 (16.2%) subjects were selected for sigmoidoscopy based on their positive galactose oxidase result or positive FOBT result. Two early stage carcinomas and 33 adenomas (0.32% and 4.2% respectively in sigmoidoscopy) were found. Another 2 660 subjects were taken for sigmoidoscopy screening. Four carcinomas and 78 adenomas were found. Of them, only two carcinoma (50%) and 17 (21.8%) or 22 (28.2%) adenomas were positive in Shams' or SPA test. But both tests combined in screening showed a rate of 61.3% in adenomas and 75.0% in cancers. 103 subjects with positive Shams' test were taken for pancolonoscopy. 82.5% showed no lesions. (ABSTRACT TRUNCATED AT 250 WORDS)
Analyzing Teachers' Stories

This article presents an integrated socio-literal approach as a way to analyze work stories. It uses a case of teachers' stories about the administration as an example. The stories focus on grumbles about various activities of members of the management of a school in a small town. The complaints appear in descriptions of the action, the characters, and, in particular, in the way the story is presented to the audience. The stories present a situation of two opposing groups-the administration and the teachers. The presentation of the stories creates a sense of togetherness among the veterans and new teachers in the staff room, and helps the integration of the new teachers into the staff. The veterans use the stories as an opportunity to express their anger at not having been assigned responsibilities on the one hand and their hopes of such promotion on the other. The stories act as a convenient medium to express criticism without entering into open hostilities. Behind them, a common principle can be discerned- the good of the school. The stories describe the infringement of various aspects of the school's social order, and it is possible to elicit from them what general pattern the teachers want to preserve in the school.
Counting Gates, Moving Qubits: Evaluating the Execution Cost of Quantum Circuits

Quantum algorithms can be written down in several forms, one of the most common is the quantum circuit representation using discrete gates. The challenge in assessing the computational cost then becomes counting those gates, with realistic costs assigned to each gate. Moreover, interacting pairs of qubits inside most quantum computers will require moving qubits. In many architectures, this will involve cellular automaton-like swapping of qubits. In general, the depth will be described in number of quantum error correction (QEC) cycles, while the total cost will be space-time ``volume'' consisting of the number of qubits involved over that set of QEC cycles. This implies that accurate estimates can be made only in the context of a particular architecture and error correction mechanism.
From political opponents to enemies? The role of perceived moral distance in the animalistic dehumanization of the political outgroup

In this paper, we analyzed the relationships among political identity, the perception of moral distance between the political ingroup and the political outgroup, and outgroup animalistic dehumanization. One correlational and one experimental study revealed a positive correlation of ingroup identification (Study 1, N = 99) and salience of ingroup membership (Study 2, N = 96) with the degree to which participants dehumanized the outgroup. This relationship was mediated by the perceived moral distance between the ingroup and the outgroup. The limitations, implications, and possible developments derived from the present findings are discussed.
Ichthyophthiriasis: emphases on the epizootiology

Ichthyophthiriasis (white spot disease) is an economically important protozoosis caused by Ichthyophthirius multifiliis in freshwater fish. Medication prevention and curation are the main methods to control this disease with vaccines in laboratory, but the efficacy of drugs practically acts on the free‐living (nonparasitic) stage of I. multifiliis and can be easily impaired by a variety of environmental factors. Thus, study on the biological properties of I. multifiliis and the complicated ecological relationships between I. multifiliis and other biotic or abiotic factors that influence epidemicity of ichthyophthiriasis will contribute to integrated control of ichthyophthiriasis. In this article, some I. multifiliis biological properties, such as systematic position and life cycle of I. multifiliis, are briefly reviewed, and the seemingly abnormal phenomenon associated with in vitro cultures is specially discussed; then, the epizootiology of ichthyophthiriasis is emphasized, which involves various biotic or abiotic factors that impact the life and action of I. multifiliis. The susceptibility and stress reaction of fish to I. multifiliis infection are stated. Also, the pathogenicity and diagnosis of ichthyophthiriasis were covered, and an overall assessment is finally made on ichthyophthiriasis control.
The CCPP-ARM Parameterization Testbed (CAPT): Where Climate Simulation Meets Weather Prediction

To significantly improve the simulation of climate by general circulation models (GCMs), systematic errors in representations of relevant processes must first be identified, and then reduced. This endeavor demands, in particular, that the GCM parameterizations of unresolved processes should be tested over a wide range of time scales, not just in climate simulations. Thus, a numerical weather prediction (NWP) methodology for evaluating model parameterizations and gaining insights into their behavior may prove useful, provied that suitable adaptations are made for implementation in climate GCMs. This method entails the generation of short-range weather forecasts by realistically initialized climate GCM, and the application of six-hourly NWP analyses and observations of parameterized variables to evaluate these forecasts. The behavior of the parameterizations in such a weather-forecasting framework can provide insights on how these schemes might be improved, and modified parameterizations then can be similarly tested. In order to further this method for evaluating and analyzing parameterizations in climate GCMs, the USDOE is funding a joint venture of its Climate Change Prediction Program (CCPP) and Atmospheric Radiation Measurement (ARM) Program: the CCPP-ARM Parameterization Testbed (CAPT). This article elaborates the scientific rationale for CAPT, discusses technical aspects of its methodology, and presents examples of its implementation in a representative climate GCM. Numerical weather prediction methods show promise for improving parameterizations in climate GCMs.
Data-Driven Reserve Prices for Social Advertising Auctions at LinkedIn

Online advertising auctions constitute an important source of revenue for search engines such as Google and Bing, as well as social networks such as Facebook, LinkedIn and Twitter. We study the problem of setting the optimal reserve price in a Generalized Second Price auction, guided by auction theory with suitable adaptations to social advertising at LinkedIn. Two types of reserve prices are deployed: one at the user level, which is kept private by the publisher, and the other at the audience segment level, which is made public to advertisers. We demonstrate through field experiments the effectiveness of this reserve price mechanism to promote demand growth, increase ads revenue, and improve advertiser experience.
Multilingual Extension of a Temporal Expression Normalizer using Annotated Corpora

This paper presents the automatic extension to other languages of TERSEO, a knowledge-based system for the recognition and normalization of temporal expressions originally developed for Spanish. TERSEO was first extended to English through the automatic translation of the temporal expressions. Then, an improved porting process was applied to Italian, where the automatic translation of the temporal expressions from English and from Spanish was combined with the extraction of new expressions from an Italian annotated corpus. Experimental results demonstrate how, while still adhering to the rule-based paradigm, the development of automatic rule translation procedures allowed us to minimize the effort required for porting to new languages. Relying on such procedures, and without any manual effort or previous knowledge of the target language, TERSEO recognizes and normalizes temporal expressions in Italian with good results (72% precision and 83% recall for recognition).
c-Myb Regulates Cell Cycle-Dependent Expression of Erbin: An Implication for a Novel Function of Erbin

In the present study, we demonstrated the cell cycle periodicity of Erbin expression with the maximal expression of Erbin in G2/M phase. A significant increase in Erbin promoter activity was observed in G2/M phase-synchronized cells. Sequence analysis revealed a c-Myb site in the core promoter region of Erbin. Mutagenesis of c-Myb consensus sequences abrogated the increased Erbin promoter activity in G2/M phase. ChIP and oligonucleotide pull-down assays validated that the recruitment of c-Myb to the consensus sequences was specific. The interaction of c-Myb with c-Myb site in the Erbin promoter was significantly enhanced in G2/M phase. Ectopic overexpression of c-Myb led to the up-regulation of Erbin promoter activity and c-Myb silencing by small interfering RNA significantly decreased Erbin protein level. Transfection of c-Myb rescued Erbin expression that was impaired by c-Myb knockdown. It proves that c-Myb and the c-Myb response element mediate the cell cycle-dependent expression of Erbin. Inactivation of Erbin causes an acceleration of the G1/S transition, the formation of multipolar spindles and abnormal chromosome congression. These results unravel a critical role of c-Myb in promoting Erbin transcription in G2/M phase and also predict an unappreciated function of Erbin in cell cycle progression.
Impact of image organizations on multimedia document retrieval

In this paper we compare ranking effectiveness of heterogeneous multimedia document retrieval when different image organizations are used for formulating queries. The quality of image queries depends on the organization of images used to make queries which in turn significantly impacts retrieval precision. CBIR (content based information retrieval) needs an effective and efficient organization of images including user interface which must be part of the configuration parameters of image retrieval research.
VoroStore -- A Secure and Reliable Data Storage for Peer-to-Peer-Based MMVEs

Virtual worlds are typically persistent. They need a reliable storage to store the state of the world. In a decentralized peer-to-peer-based virtual world, this must also be realized in a decentralized fashion. However, peers are not only unreliable. They might also be malicious trying to tamper with the stored data. Therefore we present our approach to realize a peer-to peer-based reliable and secure storage. It is based on a Voronoi tessellation to manage storage responsibilities and preserves the locality of data. Thus it allows range queries as needed by a peer-to-peer-based virtual world. Our approach guarantees availability and integrity of data with a certain controllable probability using redundant storage and routing.
Prototyping of visualization designs of 3D vector fields using POVRay rendering engine

There is a persistent quest for novel methods of visualization in order to get insight into complex phenomena in variety of scientific domains. Researchers, ex. VTK team, achieved excellent results; however, some problems connected with implementation of new techniques and quality of the final images still persist. Results of inspection of number of visualization styles of 3D vector field employing POVRay ray-tracing engine are discussed, i.e. hedgehogs, oriented glyphs, streamlines, isosurface component approach and texturing design. All styles presented have been tested using water molecule model and compared concerning computing time, informativeness and general appearance. It is shown in the work that Scene Description Language (SDL), domain specific language implemented in POVRay is flexible enough to use it as a tool for fast prototyping of novel and exploratory visualization techniques. Visualizations discussed in the paper were computed using selected components of API of ScPovPlot3D, i.e. templates written in the SDL language. Results are compared to designs already implemented in VTK.
When the lads go hunting: The ‘Hammertown mechanism’ and the conflict over wolves in Norway

Rural communities are changing. Depopulation and unemployment is accompanied by the advance of new perspectives on nature, where protection trumps resource extraction. These developments are perceived as threatening by rural working-class people with close ties to traditional land use – a situation they often meet with cultural resistance. Cultural resistance is not necessarily launched against institutionalized power, nor does it necessarily imply a desire for fundamental social change. It should rather be seen as a struggle for autonomy. However, autonomy does not entail influence outside the cultural realm. Struggles to uphold traditional rural lifestyles – for example by denouncing the current nature conservation regime – could be understood in much the same conceptual framework as Willis employed in ‘Learning to labour’. Based on an ethnographic study of the conflicts over wolf protection, we demonstrate that ‘the Hammertown mechanism’ is of a more general nature than often implied in the discussion of Willis’ work.
A search filter for increasing the retrieval of animal studies in Embase

Collecting and analysing all available literature before starting a new animal experiment is important and it is indispensable when writing systematic reviews of animal research. In practice, finding all animal studies relevant to a specific research question turns out to be anything but simple. In order to facilitate this search process, we previously developed a search filter for retrieving animal studies in the most often used biomedical database, PubMed. It is a general requirement for systematic reviews, however, that at least two databases are searched. In this report, we therefore present a similar search filter for a second important database, namely Embase. We show that our filter retrieves more animal studies than (a combination of) the options currently available in Embase. Our search filters for PubMed and Embase therefore represent valuable tools for improving the quality of (systematic) reviews and thereby of new animal experiments.