Miracle-dz/UniFAR-FTUs huggingface dataset:
Mapping Text Mining Taxonomies

Huge amounts of textual information relevant for market analysis, trending or product monitoring can be found on the Web. To make use of that information a number of text mining services were proposed that extract and categorize entities from given text. Such services have individual strengths and weaknesses so that merging results from multiple services can improve quality. To merge results, mappings between service taxonomies are needed since different taxonomies are used for categorizing extracted information. The mappings can potentially be computed by using ontology matching systems. However, the available meta data within most taxonomies is weak so that ontology matching systems currently return insufficient results. In this paper we propose a novel approach to enrich service taxonomies with instance information which is crucial for finding mappings. Based on the found instances we present a novel instance-based matching technique and metric that allows us to automatically identify equal, hierarchical and associative mappings. These mappings can be used for merging results of multiple extraction services. We broadly evaluate our matching approach on real world service taxonomies and compare to state-of-the-art approaches.
Hospitalizations in Nursing Homes: Does Payer Source Matter? Evidence From New York State

The objective of this study was to examine the reasons for different hospitalization rates between Medicaid and private-pay nursing home residents—to disentangle within-facility differences from across-facility variations in hospitalizations between these two types of residents. Multiple data sources (2003) for New York State were linked. Hospitalization was the dependent variable. Individual payer status was the main independent variable. Facilities were stratified into four groups by ownership status and bed-hold payment eligibility. We found both within-facility (Medicaid residents were more likely to be hospitalized than private-pay residents within a facility) and across-facility differences (facilities with a higher concentration of Medicaid residents were more likely to hospitalize their residents) controlling for individual and facility characteristics. The magnitude of within-facility differences varied with facility ownership and bed-hold eligibility. To reduce hospitalizations of Medicaid residents and to improve both quality of care and costs, policymakers may need to align Medicaid’s and Medicare’s incentives.
Critical study of Indian and french philosophical literature: in search of wisdom, spirituality and rationalism

The Indian philosophy is enriched with incredible, spiritual wisdom. Indian history is full of examples where the literature was specially designed to promote “the aim of life”. The French literature is known more for its romanticism in the medieval times, pre or post renaissance whereas the Indian literature reflects spiritual romanticism. To begin with the French literature, we found an influence of Granada on the French spiritual literature. It is often said that probably there is no spiritual French writer who has not read Granada, especially of the 17th century. Based on our initial research, we found that French literature is blessed with extraordinary French philosophers. The wisdom in the French literature in fact worked as a catalyst in French enlightenment. Shruti, as per the Indian mythology are the words of god passed on to the mortals and spread verbally through generations. The four Vedas come under this category. Smriti means the literature which must be remembered after listening or reading and can be written. The works like Upanishads, Brahmanas and Puranas come under this category. The very essence of the Indian philosophical wisdom is to transform the metaphysical agony into spiritual peace.
Design, optimization and characterization of a superdirective antenna array

This paper presents the design and the entire experimental characterization of a superdirective antenna array. The antenna system is composed of two closely spaced bow-tie monopoles fed by a power divider associated to a Matching Network (MN) and a Decoupling Network (DN). Given the high accuracy required for achieving superdirectivity in terms of amplitude and phase excitations, the radiating elements, the DN and the MN have been separately designed and experimentally characterized using a hybrid simulation/measurement method. Finally, the return loss and the 3D radiation patterns of the entire antenna system have been measured and compared with simulations. A 10dB directivity is achieved for this 0. 13λ spaced antenna array, which validate the superdirectivity benefit and gives perspectives in terms of miniaturized high gain antenna systems for WIFI set-top box applications.
Photosystem II Assembly in CP47 Mutant of Synechocystis sp. PCC 6803 Is Dependent on the Level of Chlorophyll Precursors Regulated by Ferrochelatase*

Accumulation of chlorophyll and expression of the chlorophyll (Chl)-binding CP47 protein that serves as the core antenna of photosystem II are indispensable for the assembly of a functional photosystem II. We have characterized the CP47 mutant with an impaired photosystem II assembly and its two spontaneous pseudorevertants with their much improved photoautotrophic growth. The complementing mutations in these pseudorevertants were previously mapped to the ferrochelatase gene (1). We demonstrated that complementing mutations dramatically decrease ferrochelatase activity in pseudorevertants and that this decrease is responsible for their improved photoautotrophic growth. Photoautotrophic growth of the CP47 mutant was also restored by in vivo inhibition of ferrochelatase by a specific inhibitor. The decrease in ferrochelatase activity in pseudorevertants was followed by increased steady-state levels of Chl precursors and Chl, leading to CP47 accumulation and photosystem II assembly. Similarly, supplementation of the CP47 mutant with the Chl precursor Mg-protoporphyrin IX increased the number of active photosystem-II centers, suggesting that synthesis of the mutated CP47 protein is enhanced by an increased Chl availability in the cell. The probable role of ferrochelatase in the regulation of Chl biosynthesis is discussed.
Second generation DNA sequencing of the mitogenome of the Chinstrap penguin and comparative genomics of Antarctic penguins

Abstract The complete mitochondrial genome of the Chinstrap penguin (Pygoscelis antarcticus) was sequenced and compared with other penguin mitogenomes. The genome is 15,972 bp in length with the number and order of protein coding genes and RNAs being very similar to that of other known penguin mitogenomes. Comparative nucleotide analysis showed the Chinstrap mitogenome shares 94% homology with the mitogenome of its sister species, Pygoscelis adelie (Adélie penguin). Divergence at nonsynonymous nucleotide positions was found to be up to 23 times less than that observed in synonymous positions of protein coding genes, suggesting high selection constraints. The complete mitogenome data will be useful for genetic and evolutionary studies of penguins.
Design of a low power Delay Locked Loop based Clock and Data Recovery circuit

A low power Delay Locked Loop based Clock and Data Recovery circuit has been designed in this paper. A standby filter is a novel feature in this design. Level tracking technique is used for data recovery. The circuit is designed using Verilog HDL. The layout of the circuit is generated and verified using Cadence SoC Encounter. Total die area and total dynamic power dissipation of the circuit is 0.01mm2 and 799. 8643µW respectively at 1.8V power supply.
Control of Expression of the RNases J1 and J2 in Bacillus subtilis

ABSTRACT In Bacillus subtilis, the dual activity 5′ exo- and endoribonucleases J1 and J2 are important players in mRNA and stable RNA maturation and degradation. Recent work has improved our understanding of their structure and mechanism of action and identified numerous RNA substrates. However, almost nothing is known about the expression of these enzymes. Here, we have identified the transcriptional and translational signals that control the expression of the rnjA (RNase J1) and rnjB (RNase J2) genes. While the rnjB gene is transcribed constitutively from a sigma A promoter, optimal expression of RNase J1 requires cotranscription and cotranslation with the upstream ykzG gene, encoding a protein of unknown function. In the absence of coupled translation, RNase J1 expression is decreased more than 5-fold. Transcription of the ykzG operon initiates at a sigma A promoter with a noncanonical −35 box that is required for optimal transcription. Biosynthesis of RNase J1 is autocontrolled within a small range (1.4-fold) and also slightly stimulated (1.4-fold) in the absence of RNase J2. These controls are weak but might be useful to maintain the overall RNase J level and possibly also equimolar amounts of the two nucleases in the cell that primarily act as a heterodimer in vivo.
Characterization of Spermatozoa Surface Antigens by Antisperm Antibodies and its Influence on Acrosomal Exocytosis

Problem: Antisperm antibodies (ASA) are the main cause of immunological infertility, they impair sperm functions by binding to the sperm membrane. The aim of this study was to characterize highly enriched sperm membrane proteins by 2‐D‐electrophoresis and to identify membrane antigens binding ASA and to evaluate the influence of ASA on the acrosome reaction (AR).
28 nm FD SOI Technology Platform RF FoM

This work provides a detailed study of 28 nm fully-depleted silicon-on-insulator (FD SOI) ultra-thin body and buried oxide (BOX) (UTBB) MOSFETs for high frequency applications. RF figures of merit (FoM), i.e. the current gain cut-off frequency (fT) and the maximum oscillation frequency (fmax), are presented for different transistor geometries. The parasitic gate and source/drain series resistances, as well as capacitances and their effect on RF performance are analyzed.
Altered histology of the thymus and spleen in contaminant‐exposed juvenile American alligators

Morphological differences in spleen and thymus are closely related to functional immune differences. Hormonal regulation of the immune system has been demonstrated in reptilian splenic and thymic tissue. Spleens and thymus were obtained from juvenile alligators at two reference sites in Florida, USA: Orange Lake and a National Wildlife Refuge, Lake Woodruff, as well as from a contaminated lake, Lake Apopka. Lake Apopka has been extensively polluted with agricultural pesticides. Tissues were prepared for histological analysis to determine if previously detected endocrine abnormalities associated with contaminant exposure might also be reflected in morphological differences in splenic and thymic structures important for immunological response. Similar tissues were taken from captive‐raised juvenile female alligators (3 years old) that were hatched from eggs collected on Lake Woodruff and Lake Apopka. Differences in thymic ratios (medulla/cortex) were found among alligators collected from the two lakes (P = 0.0051). Alligators from Lake Apopka had smaller thymic ratios than animals from either reference lake. Males from Lake Woodruff had significantly smaller lymphocyte sheaths in the spleen than females (P = 0.0009), indicative of a normal sexual dimorphism. Lymphocyte sheath width differed among females obtained from the three lakes, with females from Lake Apopka having the smallest sheath width and those from Orange Lake having the largest. Malpighian body area was largest in alligators from Orange Lake, intermediate in Lake Woodruff, and smallest in Lake Apopka. In contrast to that observed for wild‐caught animals, no difference was found in the thymic medulla/cortex ratio of captive‐raised female alligators (P = 0.378). Captive‐raised female alligators from Lake Apopka and Lake Woodruff displayed lake‐associated differences in lymphocyte sheath width as observed in wild animals; Lake Apopka alligators had smaller lymphocyte sheath width compared to Woodruff alligators (P = 0.0396). In contrast to wild‐caught animals, area of the Malpighian bodies did not differ by lake in the captive‐raised female alligators (P = 0.066). The enlarged thymic cortex suggests a change in T‐lymphocyte maturation within the thymus of alligators from a contaminated environment, Lake Apopka. The results point to alterations in the histology of the thymus and spleen. Further studies are required to examine the functional significance of these observations. J. Morphol. 256:349–359, 2003. © 2003 Wiley‐Liss, Inc.
Interactive Non-Expert Information Visualizations and their Evaluation Beyond Time and Error

In this paper we look at the current state of interactive information visualizations and how they can be evaluated beyond time and error. We focus on non-expert visualizations that contain interactivity for the user and can be found in the environments of news websites, museums and public spaces. For each environment particularities and examples are illustrated and the different categories of interaction described, including for what purposes they can or should be used. For evaluating those graphics we look at the advantages and different use cases for ”Lab Studies” and ”Into-the-Wild Studies”, and explain why qualitative and quantitative methods both are equally valuable. Furthermore we point out three aspects that should be considered when evaluating those visualizations: 1) The inclusion of the building process into evaluation, with user testings as well as expert analyses, 2) Rating the discoveries a user makes during exploration, and 3) The advantages of long-term studies.
Design and Analysis of a Slope Voltage Control for a DFIG Wind Power Plant

This paper addresses a detailed design of a wind power plant and turbine slope voltage control in the presence of communication delays for a wide short-circuit ratio range operation. The implemented voltage control scheme is based upon the secondary voltage control concept, which offers fast response to grid disturbances, despite the communication delays, i.e., this concept is based on a primary voltage control, located in the wind turbine, which follows an external voltage reference sent by a central controller, called secondary voltage control, which is controlling the voltage at the point of connection with the grid. The performance has been tested using PSCAD/EMTDC program. The plant layout used in the simulations is based on an installed wind power plant, composed of 23 doubly fed generator wind turbines. The resulting performance is evaluated using a compilation of grid code voltage control requirements. The results show that fast response to grid disturbances can be achieved using the secondary voltage control scheme, and the fulfillment of the design requirements can be extended for a wide range of short-circuit ratios.
Expression of Mediators of Renal Injury in the Remnant Kidney of ROP Mice Is Attenuated by Cyclooxygenase-2 Inhibition

To investigate the effects of cyclooxygenase-2 (COX-2) inhibition on renal injury of mice, ROP mice were subjected to subtotal ablation (‘remnant’). A subset of the remnant group was treated with a selective COX-2 inhibitor, SC58236, in the drinking water. At 12 weeks the remnant group developed significant albuminuria (181.3 ± 15.8 µg/24 h), which was blunted by SC58236 treatment (138.9 ± 17.1; p < 0.05 compared to remnant). SC58236 did not alter systemic blood pressure or GFR significantly. Immunoreactive COX-2 was upregulated in remnant (1.88 ± 0.35 fold sham, n = 8, p < 0.05), which was blunted by SC58236 (to 1.26 ± 0.31 fold sham). Collagen IV mRNA increased significantly in remnant kidneys (2.69 ± 0.34 fold sham, n = 8, p < 0.05), and this increase was inhibited by SC58236 treatment (to 1.84 ± 0.32 fold control). Immunoreactive TGF-β1, connective tissue growth factor, HGF receptor, c-Met, and fibronectin all increased in remnant (2.85 ± 0.51, 3.83 ± 0.55, 2.56 ± 0.31, and 2.80 ± 0.39 fold sham respectively, n = 4–8, p < 0.05), and SC58236 blunted the increases (to 1.45 ± 0.34, 1.85 ± 0.13, 1.75 ± 0.30, and 1.60 ± 0.32 fold sham). Immunohistochemistry indicated that the major localization for these progression factors was in the tubulointerstitium, especially in the scar area, which is in agreement with the expression of a macrophage marker, F4/80. Therefore, these results indicate that in a mouse model of subtotal renal ablation, COX-2 inhibition blocks expression of mediators of renal tubulointerstitial injury.
IL 10 R 1 loss-of-function alleles in rheumatoid arthritis and systemic lupus erythematosus

Objective IL-10 is a pleiotropic cytokine involved in the regulation of innate and cell-mediated immunity and a key mediator within the disturbed SLE immune system. IL-10 binds to IL10R1, which is expressed on a variety of immune cells and activates the JAK-STAT pathway. Two (out of several known) genetic IL10R1 variants may alter IL-10 binding or signal transduction. Here we investigate the differential activity of these IL10R1 variants and their possible association with RA or SLE
VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3

Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs). The two principal isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in adult brain that broadly distinguishes cortical (VGLUT1) and subcortical (VGLUT2) systems, and correlates with distinct physiological properties in synapses expressing these isoforms. Differential trafficking of VGLUT1 and 2 has been suggested to underlie their functional diversity. Increasing evidence suggests individual synaptic vesicle proteins use specific sorting signals to engage specialized biochemical mechanisms to regulate their recycling. We observed that VGLUT2 recycles differently in response to high frequency stimulation than VGLUT1. Here we further explore the trafficking of VGLUT2 using a pHluorin-based reporter, VGLUT2-pH. VGLUT2-pH exhibits slower rates of both exocytosis and endocytosis than VGLUT1-pH. VGLUT2-pH recycling is slower than VGLUT1-pH in both hippocampal neurons, which endogenously express mostly VGLUT1, and thalamic neurons, which endogenously express mostly VGLUT2, indicating that protein identity, not synaptic vesicle membrane or neuronal cell type, controls sorting. We characterize sorting signals in the C-terminal dileucine-like motif, which plays a crucial role in VGLUT2 trafficking. Disruption of this motif abolishes synaptic targeting of VGLUT2 and essentially eliminates endocytosis of the transporter. Mutational and biochemical analysis demonstrates that clathrin adaptor proteins (APs) interact with VGLUT2 at the dileucine-like motif. VGLUT2 interacts with AP-2, a well-studied adaptor protein for clathrin mediated endocytosis. In addition, VGLUT2 also interacts with the alternate adaptors, AP-1 and AP-3. VGLUT2 relies on distinct recycling mechanisms from VGLUT1. Abrogation of these differences by pharmacological and molecular inhibition reveals that these mechanisms are dependent on the adaptor proteins AP-1 and AP-3. Further, shRNA-mediated knockdown reveals differential roles for AP-1 and AP-3 in VGLUT2 recycling.
CD8-positive T-cell lymphoproliferative disorder associated with Epstein-Barr virus-infected B-cells in a rheumatoid arthritis patient under methotrexate treatment

We report a 48-year-old female who developed lymphoproliferative disorder (LPD) during treatment of rheumatoid arthritis (RA) with methotrexate (MTX). She presented with multiple tumors in the cervical lymph nodes (LNs), multiple lung shadows and round shadows in both kidneys with pancytopenia and a high CRP level. The LN showed CD8-positive T-cell LPD associated with Epstein-Barr (EB) virus-infected B-cells. Clonality assays for immunoglobulin (Ig) heavy chain and T-cell receptor gamma (TCRγ) were negative. The cessation of MTX without chemotherapy resulted in the complete disappearance of the tumors and abnormal clinical features. We compared this case with previously published ones and discuss the pathological findings, presuming that the proliferation of CD8 T-cells was a reactive manifestation to reactivated EB virus-infected B-cells.
A randomized controlled trial to evaluate antiretroviral salvage therapy guided by rules-based or phenotype-driven HIV-1 genotypic drug-resistance interpretation with or without concentration-controlled intervention: the Resistance and Dosage Adapted Regimens (RADAR) study.

BACKGROUND It is not well defined whether concentration-controlled intervention (CCI) and rules-based human immunodeficiency virus (HIV) type 1 genotype drug-resistance interpretation (GI) or virtual phenotype drug-resistance interpretation (VPI) may improve the outcome of HIV salvage therapy. METHODS In a prospective, randomized, controlled trial, patients were randomized (on a factorial basis) to change treatment after either GI or VPI, and they then were further randomized to the control arm (no CCI) or the CCI arm. Protease inhibitor (PI) and nonnucleoside reverse-transcriptase inhibitor (NNRTI) trough concentration (Ctrough) values were determined at weeks 1, 4, 12, and 24 of the study. RESULTS Among 230 patients, virological benefit (defined by an HIV RNA load of <400 copies/mL at week 24) was not statistically different, either between patients in the GI and VPI arms or between patients in the CCI and control arms. A virological benefit was found for patients in the CCI arm, compared with patients in the control arm, but this benefit was not statistically significant (56.8% vs. 64.3% at week 4 and 63.6% vs. 74% at week 12). Dosage adaptation was possible for only a fraction of patients, because of low rates of treatment adherence or patient refusal to increase dosages. In the logistic regression analysis, independent predictors of virological response at week 24 were a PI Ctrough value and/or an NNRTI Ctrough value in the higher quartiles (or above cutoff levels) and a low number of PIs previously received. Moreover, receipt of a regimen that contained PIs boosted with ritonavir was an independent predictor of virological response. CONCLUSIONS The present study did not support the routine use of CCI for patients undergoing salvage treatment, probably as a result of existing difficulties associated with its clinical application. However, a higher Ctrough value appeared to be correlated with treatment response. No major differences were found between VPI or GI when they are used together with expert advice for the selection of salvage treatment combinations.
Phenotypic Characterization of hns mutants of Aggregatibacter actinomycetemcomitans

Aggregatibacter actinomycetemcomitans is associated with aggressive forms of periodontitis. The mechanisms that control the expression of virulence factors are essentially unknown. Histone-like nucleoid structuring protein, H-NS, is a DNA binding protein that has been shown to influence hundreds of genes in Gram-negative bacteria. H-NS usually acts as a transcriptional silencer and has a negative influence on gene expression. H-NS has not been studied in A. actinomycetemcomitans before, and its effects on gene expression in this species were lacking. This study aimed to investigate if lack of H-NS expression might result in apparent phenotypical differences regarding gene expression with emphasis on virulence. For this we have used the A. actinomycetemcomitans rough-colony serotype a strain, D7S, its smooth-colony derivative D7SS, and hns mutants of D7S and D7SS. Our results show that smooth colony strain D7SS releases a larger amount of vesicles as compared to the rough D7S. The D7S hns mutant appeared to exhibit pili that were shorter than those of the parental strain, and this was not due to altered expression of RcpA in the hns mutant. As judged by Silver-staining, and Western blot analysis, H-NS may influence the level of several proteins. Taken together, our study supports that H-NS is involved in the regulation of virulence factor expression in A. actinomycetemcomitans.