Miracle-dz/UniFAR-FTUs huggingface dataset:
Chemical synthesis of metal nanoparticles in aqueous solutions with the presence of some additives

Metal nanoparticles having interesting shapes can be prepared in aqueous solutions through simple reductions of metal ions with the presence of some additive reagents, such as cetyltrimethylammonium bromide and hexamethylenetetramine. In this review, some successful results for shape-controlled synthesis of metal nanoparticles in our group are summarized, which includes the synthesis of palladium nanocubes, palladium nanobricks, gold nanotripods. In addition, combining with indium tin oxide electrode surfaces, shape-controlled growth is shown to be possible to form gold nanoplates and copper oxide nanowires. Even in relatively mild synthetic conditions, interesting shape-controlled synthesis of metal nanoparticles is possible.
Anti–PD-1 Antibody Treatment Promotes Clearance of Persistent Cryptococcal Lung Infection in Mice

Activation of immunomodulatory pathways in response to invasive fungi can impair clearance and promote persistent infections. The programmed cell death protein-1 (PD-1) signaling pathway inhibits immune effector responses against tumors, and immune checkpoint inhibitors that block this pathway are being increasingly used as cancer therapy. The objective of this study was to investigate whether this pathway contributes to persistent fungal infection and to determine whether anti–PD-1 Ab treatment improves fungal clearance. Studies were performed using C57BL/6 mice infected with a moderately virulent strain of Cryptococcus neoformans (52D), which resulted in prolonged elevations in fungal burden and histopathologic evidence of chronic lung inflammation. Persistent infection was associated with increased and sustained expression of PD-1 on lung lymphocytes, including a mixed population of CD4+ T cells. In parallel, expression of the PD-1 ligands, PD-1 ligands 1 and 2, was similarly upregulated on specific subsets of resident and recruited lung dendritic cells and macrophages. Treatment of persistently infected mice for 4 wk by repetitive administration of neutralizing anti–PD-1 Ab significantly improved pulmonary fungal clearance. Treatment was well tolerated without evidence of morbidity. Immunophenotyping revealed that anti–PD-1 Ab treatment did not alter immune effector cell numbers or myeloid cell activation. Treatment did reduce gene expression of IL-5 and IL-10 by lung leukocytes and promoted sustained upregulation of OX40 by Th1 and Th17 cells. Collectively, this study demonstrates that PD-1 signaling promotes persistent cryptococcal lung infection and identifies this pathway as a potential target for novel immune-based treatments of chronic fungal disease.
Indiscreet Logs: Persistent Diffie-Hellman Backdoors in TLS

Software implementations of discrete logarithm based cryptosystems over finite fields typically make the assumption that any domain parameters they are presented with are trustworthy, i.e., the parameters implement cyclic groups where the discrete logarithm problem is assumed to be hard. An informal and widespread justification for this seemingly exists that says validating parameters at run time is too computationally expensive relative to the perceived risk of a server sabotaging the privacy of its own connection. In this paper we explore this trust assumption and examine situations where it may not always be justified. We conducted an investigation of discrete logarithm domain parameters in use across the Internet and discovered evidence of a multitude of potentially backdoored moduli of unknown order in TLS and STARTTLS spanning numerous countries, organizations, and protocols. Although our disclosures resulted in a number of organizations taking down suspicious parameters, we argue the potential for TLS backdoors is systematic and will persist until either until better parameter hygiene is taken up by the community, or finite field based cryptography is eliminated altogether.
An Adaptive Controller for Power System Load-Frequency Control

An adaptive controller is presented for load-frequency control of power systems. It uses a PI (proportional-integral) adaptation to satisfy the hyperstability condition for taking care of the parameter changes of the system. Only the available information on the states and output are required for the control. No explicit parameter identification is needed. The controller can be designed by using a reduced plant model to simplify the design without degrading the performance much, so it is very easy to implement practically. The simulation results indicate that good control performance can be obtained and that the performance is sensitive to the plant parameter changes. The control remains effective in the presence of generation rate constraints. >
N-(3-Chlorophenyl)maleamic acid

In the title compound, C10H8ClNO3, the molecular conformation is stabilized by two intramolecular hydrogen bonds. The first is a short O—H⋯O hydrogen bond within the maleamic acid unit and the second is a C—H⋯O hydrogen bond which connects the amide group with the phenyl ring. The maleamic acid unit is essentially planar, with an r.m.s. deviation of 0.044 Å, and makes a dihedral angle of 15.2 (1)° with the phenyl ring. In the crystal, intermolecular N—H⋯O hydrogen bonds link the molecules into C(7) chains running [010].
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus.

BACKGROUND The metabolic effects and mechanism of action of metformin are still poorly understood, despite the fact that it has been used to treat patients with non-insulin-dependent diabetes mellitus (NIDDM) for more than 30 years. METHODS In 10 obese patients with NIDDM, we used a combination of isotope dilution, indirect calorimetry, bioimpedance, and tissue-balance techniques to assess the effects of metformin on systemic lactate, glucose, and free-fatty-acid turnover; lactate oxidation and the conversion of lactate to glucose; skeletal-muscle glucose and lactate metabolism; body composition; and energy expenditure before and after four months of treatment. RESULTS Metformin treatment decreased the mean (+/- SD) glycosylated hemoglobin value from 13.2 +/- 2.2 percent to 10.5 +/- 1.6 percent (P < 0.001) and reduced fasting plasma glucose concentrations from 220 +/- 41 to 155 +/- 28 mg per deciliter (12.2 +/- 0.7 to 8.6 +/- 0.5 mmol per liter) (P < 0.001). Although resting energy expenditure did not change, the patients lost 2.7 +/- 1.3 kg of weight (P < 0.001), 88 percent of which was adipose tissue. The mean (+/- SE) rate of plasma glucose turnover (hepatic glucose output and systemic glucose disposal) decreased from 2.8 +/- 0.2 to 2.0 +/- 0.2 mg per kilogram of body weight per minute (15.3 +/- 0.9 to 10.8 +/- 0.9 mumol per kilogram per minute) (P < 0.001), as a result of a decrease in hepatic glucose output; systemic glucose clearance did not change. The rate of conversion of lactate to glucose (gluconeogenesis) decreased by 37 percent (P < 0.001), whereas lactate oxidation increased by 25 percent (P < 0.001). There were no changes in the plasma lactate concentration, plasma lactate turnover, muscle lactate release, plasma free-fatty-acid turnover, or uptake of glucose by muscle. CONCLUSIONS Metformin acts primarily by decreasing hepatic glucose output, largely by inhibiting gluconeogenesis. It also seems to induce weight loss, preferentially involving adipose tissue.
Mono- and Bilingual Retrieval Experiments with a Social Science Document Corpus

This paper reports on our participation in CLEF 2005‘s domain-specific retrieval track. The experiments were based on previous experiences with the GIRT document corpus and were run in parallel to the multi-lingual experiments for CLEF 2005. We optimized the parameters of the system with one corpus from 2004 and applied these settings to the domain specific task. In that manner, the robustness of our approach over different document collection was assessed.
Locoregional and Microvascular Free Tissue Reconstruction of the Lateral Skull Base

Abstract The goals of reconstruction following any oncologic extirpation are preservation of function, restoration of cosmesis, and avoidance of morbidity. Anatomically, the lateral skull base is complex and conceptually intricate due to its three-dimensional morphology. The temporal bone articulates with five other cranial bones and forms many sutures and foramina through which pass critical neural and vascular structures. Remnant defects following resection of lateral skull base tumors are often not amenable to primary closure. As such, numerous techniques have been described for reconstruction including local rotational muscle flaps, pedicled flaps with skin paddle, or free tissue transfer. In this review, the advantages and disadvantages of each reconstructive method will be discussed as well as their potential complications.
Incidence of extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasms of the pancreas

Background and aims Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have been reported to be associated with extrapancreatic malignancies, but there have been no prospective studies evaluating the incidence of extrapancreatic cancers in patients with IPMNs. In this study, the frequency of patients with IPMNs developing extrapancreatic cancers during follow-up was examined. Methods 642 patients with IPMNs were prospectively followed up for 4.8 years on average. They underwent clinical examination at least twice a year. The incidence of the observed extrapancreatic malignancies was compared with the expected incidence of the age- and gender-matched general Japanese population based on the Vital Statistics of Japan. Results 40 extrapancreatic cancers developed in 39 patients during follow-up (1.3% per year). The most common malignancies were hepatocellular (n=7), colorectal (n=6), gastric (n=6), lung (n=5) and prostate cancers (n=4). The calculated standardised incidence rate of each of the malignancies was not significant, as follows: hepatocellular 2.17 (95% CI 0.87 to 4.47), colorectal 1.02 (0.37 to 2.21), gastric 0.76 (0.28 to 1.66), lung 0.75 (0.24 to 1.76) and prostate 1.00 (0.71 to 1.29). Pancreatic cancer was observed in 17 patients during the same period, with a standardised incidence rate of 10.7 (6.2 to 17.1). Conclusions The incidence of extrapancreatic malignancies in patients with IPMNs was similar to that in the general population, whereas the incidence of pancreatic cancers was significantly high. Intraductal papillary mucinous neoplasms are not associated with systemic carcinogenesis except for pancreatic cancer.
High-speed InP/InGaAs heterojunction bipolar transistors

Very-high-performance common-emitter InP/InGaAs single heterojunction bipolar transistors (HBTs) grown by metalorganic molecular beam epitaxy (MOMBE) are reported. They exhibit a maximum oscillation frequency (f/sub T/) of 180 GHz at a current density of 1*10/sup 5/ A/cm/sup 2/. this corresponds to an (R/sub B/C/sub BC/)/sub eff/=f/sub T//(8 pi f/sup 2//sub max/) delay time of 0.12 ps, which is the smallest value every reported for common-emitter InP/InGaAs HBTs. The devices have 11 mu m/sup 2/ total emitter area and exhibit current gain values up to 100 at zero base-collector bias voltage. The breakdown voltage of these devices is high with measured BV/sub CEO/ and BV/sub CEO/ of 8 and 17 V, respectively. <<ETX>>
Fiscal Deficits, Current Account Dynamics and Monetary Policy

This paper develops a stochastic two-country "perpetual youth" Dynamic New Keynesian model of the international business cycle with incomplete international financial markets and stationary net foreign assets. The model allows for a thorough analysis of the interaction of endogenous monetary policy with endogenous, non-balanced budget fiscal policy. We derive the dynamic and cyclical properties of fiscal deficit feedback rules under alternative monetary regimes, discuss the international transmission of productivity shocks, and the implications for net foreign assets and exchange rate dynamics. Our results imply that the degree of "fiscal discipline", i.e. the extent to which the fiscal rule responds to debt dynamics, is crucial for the dynamics of net foreign assets. We show that under low fiscal discipline (characterizing most industrialized countries, first and foremost the U.S.) temporary positive productivity shocks may result in highly persistent deteriorations of the external position in the medium run. Our results also suggest that any attempt by monetary policy alone to stabilize the dynamics of net foreign assets would induce excessive and costly fluctuations of the exchange rate.
Needle-Free Delivery of Acetalated Dextran-Encapsulated AR-12 Protects Mice from Francisella tularensis Lethal Challenge

ABSTRACT Francisella tularensis causes tularemia and is a potential biothreat. Given the limited antibiotics for treating tularemia and the possible use of antibiotic-resistant strains as a biowarfare agent, new antibacterial agents are needed. AR-12 is an FDA-approved investigational new drug (IND) compound that induces autophagy and has shown host-directed, broad-spectrum activity in vitro against Salmonella enterica serovar Typhimurium and F. tularensis. We have shown that AR-12 encapsulated within acetalated dextran (Ace-DEX) microparticles (AR-12/MPs) significantly reduces host cell cytotoxicity compared to that with free AR-12, while retaining the ability to control S. Typhimurium within infected human macrophages. In the present study, the toxicity and efficacy of AR-12/MPs in controlling virulent type A F. tularensis SchuS4 infection were examined in vitro and in vivo. No significant toxicity of blank MPs or AR-12/MPs was observed in lung histology sections when the formulations were given intranasally to uninfected mice. In histology sections from the lungs of intranasally infected mice treated with the formulations, increased macrophage infiltration was observed for AR-12/MPs, with or without suboptimal gentamicin treatment, but not for blank MPs, soluble AR-12, or suboptimal gentamicin alone. AR-12/MPs dramatically reduced the burden of F. tularensis in infected human macrophages, in a manner similar to that of free AR-12. However, in vivo, AR-12/MPs significantly enhanced the survival of F. tularensis SchuS4-infected mice compared to that seen with free AR-12. In combination with suboptimal gentamicin treatment, AR-12/MPs further improved the survival of F. tularensis SchuS4-infected mice. These studies provide support for Ace-DEX-encapsulated AR-12 as a promising new therapeutic agent for tularemia.
A controlled trial of diazepam withdrawal in chronically anxious outpatients

Twenty‐four middle‐aged male chronically anxious outpatients who were taking diazepam at a mean dose of 17 mg/day for a mean duration of 5 years were assigned to maintenance (M), gradual withdrawal (GW) or abrupt withdrawal (AW) and followed weekly. No differences were seen in two self‐report anxiety measures or in withdrawal symptoms between groups. Hamilton Anxiety Rating Scale scores were slightly elevated (F = 2.34, P < 0.05) in the AW patients at a mean duration of 4 weeks off diazepam. Thus, withdrawal from chronic diazepam (10–30 mg/day) use produced no prominent withdrawal syndrome, but the suggestion of graduai anxiety recurrence indicates the need for longer‐term follow‐up studies to adequately assess maintenance efficacy.
Di-μ-adipato-κ4 O 1:O 6-bis{aqua[5,6-diphenyl-3-(pyridin-2-yl)-1,2,4-triazine-κ2 N 2,N 3]copper(II)}

In the centrosymmetric binuclear title complex, [Cu2(C6H8O4)2(C20H14N4)2(H2O)2] or [Cu2(PDPT)2(C6H8O4)2(H2O)2] (PDPT = 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine, the Cu atom displays a distorted square-pyramidal coordination environment with the basal plane occupied by two PDPT N atoms and two O atoms from different adipate dianions while a water molecule is located at the apical position. Of the two water H atoms, one participates in an intramolecular hydrogen bond whereas the second participates in an intermolecular hydrogen bond, which leads to the formation of a chain along [010].
Identification in Auctions with Selective Entry

This paper considers nonparametric identification of a two-stage entry and bidding game we call the Affiliated-Signal (AS) model. This model assumes that potential bidders have private values, observe signals of their values prior to entry, and then choose whether to undertake a costly entry process, but imposes only minimal structure on the relationship between signals and values. It thereby nests a wide range of entry processes, including in particular the Samuelson (1985) and Levin and Smith (1994) models as special cases. Working within the AS model, we map variation in factors affecting entry behavior (potential competition or entry costs) into identified bounds on model fundamentals. These bounds are constructive, collapse to point identification when available entry variation is continuous, and can readily be refined to produce the pointwise sharp identified set. We then extend our core results to accommodate nonseparable unobserved auction-level heterogeneity and potential endogeneity of entry shifters, thereby establishing a formal identification framework for structural analysis of auctions with selective entry.
Realistic conductivity geometry model of the human head for interpretation of neuromagnetic data

The computational and practical aspects of a realistically shaped multilayer model for the conductivity geometry of the human head are discussed. A method to handle the numerical difficulties caused by the presence of poorly conducting skull is presented. Using the method, both the potential on the surface of the head and the magnetic field outside the head can be computed accurately. The procedure is tested with the multilayer sphere model, for which analytical expressions are available. The method is then applied to a realistically shaped head model, and it is shown numerically that for the computation of B produced by cerebral current sources, it is sufficient to consider a brain-shaped homogeneous conductor only, since the secondary currents on the outer interfaces give only a negligible contribution to the magnetic field outside the head. Comparisons with the sphere model are included to pinpoint areas where the homogeneous conductor model provides essential improvements in the calculation of the magnetic field outside the head. <<ETX>>
MultiPLX: automatic grouping and evaluation of PCR primers

UNLABELLED MultiPLX is a new program for automatic grouping of PCR primers. It can use many different parameters to estimate the compatibility of primers, such as primer-primer interactions, primer-product interactions, difference in melting temperatures, difference in product length and the risk of generating alternative products from the template. A unique feature of the MultiPLX is the ability to perform automatic grouping of large number (thousands) of primer pairs. AVAILABILITY Binaries for Windows, Linux and Solaris are available from http://bioinfo.ebc. ee/download/. A graphical version with limited capabilities can be used through a web interface at http://bioinfo.ebc. ee/multiplx/. The source code of the program is available on request for academic users. CONTACT maido.remm@ut.ee.
Association of low educational status with microvascular complications in type 2 diabetes: Jaipur diabetes registry

Objective: To determine the association of educational status (ES), as marker of socioeconomic status, with the prevalence of microvascular complications in diabetes. Methods: Successive patients (n = 1214) presenting to our center were evaluated for sociodemographic, anthropometric, clinical, and therapeutic variables. Subjects were classified according to ES into Group 1 (illiterate, 216); Group 2 (≤ primary, 537), Group 3 (≤ higher secondary, 312), and Group 4 (any college, 149). Descriptive statistics is reported. Results: Mean age of patients was 52 ± 10 years, duration of diabetes 7 ± 7 years and 55% were men. Prevalence of various risk factors was smoking/tobacco 25.5%, obesity body mass index ≥25 kg/m2 64.0%, abdominal obesity 63.4%, hypertension 67.5%, high fat diet 14.5%, low fruits/vegetables 31.8%, low fiber intake 60.0%, high salt diet 16.9%, physical inactivity 27.5%, coronary or cerebrovascular disease 3.0%, and microvascular disease (peripheral, ocular or renal) in 20.7%. Microvascular disease was significantly greater in illiterate (25.9%) and low (23.6%) compared to middle (15.0%) and high (14.7%) ES groups (P < 0.05). Age- and sex-adjusted logistic regression analysis revealed that in illiterate and low ES groups respectively, prevalence of smoking/tobacco use (odds ratio 3.84, confidence interval: 09–7.05 and 2.15, 1.36–3.41); low fruit/vegetable (2.51, 1.53–4.14 and 1.99, 1.30–3.04) and low fiber intake (4.02, 2.50–6.45 and 1.78, 1.23–2.59) was greater compared to high ES. Poor diabetes control (HbA1c >.0%) was significantly greater in illiterate (38.0%), low (46.0%), and middle (41.0%) compared to high (31.5%) ES subjects (P < 0.05). Conclusions: There is a greater prevalence of the microvascular disease in illiterate and low ES diabetes patients in India. This is associated with the higher prevalence of smoking/tobacco use, poor quality diet, and sub-optimal diabetes control.
Global stabilization of systems containing a double integrator using a saturated linear controller

SUMMARY In this paper, we present a Lyapunov function for systems containing a double integrator and with controller saturation. This Lyapunov function is composed of a positive-semide"nite quadratic term and an integral term. The main result provides a su$cient condition that guarantees a system with a double integrator can be globally stabilized by a saturating linear controller. For a triple-integrator system the saturated linear controller does not satisfy the su$cient condition, which agrees with the known result. Copyright ( 1999 John Wiley & Sons, Ltd.
The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses

Summary: The liver remains a hematopoietic organ after birth and can produce all leukocyte lineages from resident hematopoietic stem cells. Hepatocytes produce acute phase proteins and complement in bacterial infections. Liver Kupffer cells are activated by various bacterial stimuli, including bacterial lipopolysaccharide (LPS) and bacterial superantigens, and produce interleukin (IL)‐12. IL‐12 and other monokines (IL‐18 etc.) produced by Kupffer cells activate liver natural killer (NK) cells and NK1.1 Ag+ T cells to produce interferon‐g and thereby acquire cytotoxicity against tumors and microbe‐infected cells. These liver leukocytes and the T helper 1 immune responses induced by them thus play a crucial role in the first line of defense against bacterial infections and hematogenous tumor metastases. However, if this defense system is inadequately activated, shock associated with multiple organ failure takes place. Activated liver NK1.1 Ag+ T cells and NK cells also cause hepatocyte injury. NK1.1 Ag+ T cells and another T‐cell subset with an intermediate T‐cell receptor, CD122+CD8+ T cells, can develop independently of thymic epithelial cells. Liver NK cells and NK1.1 Ag+ T cells physiologically develop in situ from their precursors, presumably due to bacterial antigens brought from the intestine via the portal vein. NK cells activated by bacterial superantigens or LPS are also probably involved in the vascular endothelial injury in Kawasaki disease.