Miracle-dz/UniFAR-FTUs huggingface dataset:
Differential sensitivity of the brain ATP-dependent and GTP-dependent succinyl-CoA synthetase to vanadium ions. Developmental aspects.

We have recently found that both vanadate and vanadyl inhibit ATP-dependent succinyl-CoA synthetase (A-SCS) solubilized from the rat brain mitochondria. Aim of the present study was to estimate a proportion of A-SCS to G-SCS in adult and 5-day-old rat brain and their susceptibility to vanadium ions. The G-SCS to A-SCS ratio of 5-day-old brains was by 196% higher than that in adults. This is in accordance with previous observation that G-SCS is high in tissues metabolizing ketone bodies. Both G-SCS and A-SCS differ in their susceptibility towards vanadium ions. A-SCS of adult brain was more sensitive to vanadate (IC 50 1.6.10(-5) mol.l-1) than was G-SCS (IC 50 6.2.10(-5) mol.l-1). On the contrary G-SCS was more sensitive to vanadyl (IC 50 3.5.10(-4) mol.l-1) than was A-SCS (IC 50 9.0.10(-4) mol.l-1). Also autophosphorylation of G-SCS a-subunit was more resistant to vanadate than A-SCS. In contrast to the adult SCS forms, almost equal susceptibility of A-SCS and G-SCS to vanadyl and vanadate was observed in infant brains. The results suggest some structural (functional) differences between two SCS forms in adults and also between infant and adult G-SCS.
Observation temps-réel de programmes Caml

Pour mettre au point un programme, tant du point de vue de sa correction que de ses performances, il est naturel de chercher a observer son execution. On peut ainsi chercher a observer la gestion de la memoire, le temps passe dans une certaine partie du code, ou encore certaines valeurs calculees par le programme. De nombreux outils permettent de telles observations (moniteur systeme, profiler ou debugger generiques ou specifiques au langage, instrumentation explicite du code, etc.). Ces outils ne proposent cependant que des analyses > ou des observations tres limitees. Cet article presente Ocamlviz, une bibliotheque pour instrumenter du code OCaml et des outils pour visualiser ensuite son execution, en temps-reel et de maniere distante.
A Novel Hybrid Technique for Exchange Rate Forecasting

Original: 27 Apr. 2015 Revised: 14 June 2015 Accepted: 25 June 2015 Published online: 20 Dec. 2015 Exchange rate prices play a significant role in economic and financial systems. The precise forecasting of the exchange rate will aid to predict the situations of other aspects in the future. This offers useful information for economist traders to fulfill vital actions to eliminate risks that might lead to financial losses. One vital and common approach for forecasting is a quantitative technique. The quantitative technique is split into two approaches; fundamental and technical analysis. Both approaches have one different, which is the economic factor. The fundamental analysis uses economic factors while the other not, but both of them have drawbacks. In fundamental technique, the forecasters cannot understand the economic factors totally, the values and quantity of the factors unstable, while the technical analysis neglects the factors totally. This paper suggests a new technique which is appeared to be as a hybridized of the both techniques for forecasting exchange rate prices to overcome the issues mentioned above. The proposed technique makes new factors that have real values and have a real impact on the accurate result. It also derives the inputs and factors in the prediction models by a feature extraction technique which produces very accurate results.
Stability Analysis for a Class of Nonlinear Neural Networks with Multiple Delays

This paper investigates the global asymptotic stability (GAS) for a class of nonlinear neural networks with multiple delays. Based on Lyapunov stability theory, homeomorphism and the linear matrix inequality (LMI) technique, a new sufficient condition is proposed for (i) existence (ii) uniqueness and (iii) global asymptotic stability of equilibrium point, of a class of nonlinear neural networks without assuming that activation functions are bounded. An example is given to illustrate the effectiveness of our new stability criteria.
Confrontation of Modified Newtonian Dynamics Predictions with Wilkinson Microwave Anisotropy Probe First Year Data

I present a model devoid of nonbaryonic cold dark matter (CDM) that provides an acceptable fit to the Wilkinson Microwave Anisotropy Probe (WMAP) data for the power spectrum of temperature fluctuations in the cosmic background radiation. An a priori prediction of such no-CDM models was a first-to-second peak amplitude ratio A1 : 2 ≈ 2.4. WMAP measures A1 : 2 = 2.34 ± 0.09. The baryon content is the dominant factor in fixing this ratio; no-CDM models that are consistent with the WMAP data are also consistent with constraints on the baryon density from the primordial abundances of 2H, 4He, and 7Li. However, in order to match the modest width of the acoustic peaks observed by WMAP, a substantial neutrino mass is implied: mν ≈ 1 eV. Even with such a heavy neutrino, structure is expected to form rapidly under the influence of modified Newtonian dynamics. Consequently, the epoch of reionization should occur earlier than is nominally expected in ΛCDM. This prediction is realized in the polarization signal measured by WMAP. An outstanding test is in the amplitude of the third acoustic peak. Experiments that probe high l appear to favor a third peak that is larger than predicted by the no-CDM model.
Incorporation of spin‐labelled amino acids into proteins

The elucidation of structure and function of proteins and membrane proteins by EPR spectroscopy has become increasingly important in recent years as technological advances have been made in the design of spectrometers and in the chemistry of the nitroxide group. These new developments have increased the demand for tailor‐made amino acids carrying a spin label on the one hand and for reliable methods for their incorporation into proteins on the other. Here we describe methods for site‐specific spin labelling of proteins. It is shown that a combination of recombinant synthesis of proteins with chemically produced peptides (expressed protein ligation) allows the preparation of site‐specifically spin‐labelled proteins. Copyright © 2005 John Wiley & Sons, Ltd.
Design of Robust Optimal Feedforward Controllers for Periodic Disturbances

This paper proposes a new methodology to design robust optimal feedforward controllers for the attenuation of periodic disturbances in the presence of parametric plant uncertainty and uncertainty on the period of the disturbance. The controller is parameterized as a finite impulse response sequence and a robust optimization problem is formulated to compute its parameters. The robust optimization problem is converted into a semidefinite program by the use of the generalized KYP lemma. The potential of the proposed framework is demonstrated on simulation through comparison with two feedforward approaches from literature.
Alterations and prognostic significance of p16 and p53 protein expression in subgroups of cutaneous melanoma

The role of p16 and p53 alterations in cutaneous melanoma has been recently discussed, but it remains to be clarified. In the present immunohistochemical study, the expression of p16 and p53 proteins and their possible prognostic relevance have been examined in 102 melanomas of the aggressive nodular type. Twelve percent showed a strong expression of p53 protein, and these cases were significantly more frequent in the head/neck area compared with other sites (32% vs. 6%). Expression of p16 protein was negative or weak in 9% of the cases, and this tended to be less frequent in head/neck tumors compared with the others (0% vs. 12%). Whereas p53 staining was not prognostically important, loss of p16 staining was significantly associated with markedly reduced recurrence free and patient survival in univariate analysis (product‐limit method). In multivariate analysis, lack of p16 staining was significantly associated with recurrent disease (p = 0.013). Our findings indicate an important role of altered p16 protein expression in a subgroup of melanoma patients. Int. J. Cancer 74:535–539, 1997. © 1997 Wiley‐Liss, Inc.
A history of research on yeasts 2: Louis Pasteur and his contemporaries, 1850–1880

Introduction . 755 Pasteur's passage from chemistry to microbiology . 756 Pasteur on alcoholic fermentation . 758 Problem of distinguishing between activities of whole organisms and of enzymes . 760 Quantitative differences between aerobic and anaerobic sugar utilization . 762 Yeasts of wine and beer . 763 References . 769
DISORDERS OF CAPILLARY PERMEABILITY

True capillary permeability, in the sense of unit rate of transfer across a unit area of capillary membrane of unit thickness with a unit pressure gradient across it, is not measurable in man. What can be measured, though, is the overall rate of transfer of substances from the intravascular to the extravascular space, and in practice, of course, it is changes in this bulk transfer which are important clinically, regardless of whether it is the capillary area or thickness or the pressure acting across the membrane which is abnormal. In this review we shall be concerned therefore with overall transfer and not with true permeability, although for convenience we shall use the term capillary permeability. Furthermore, since serum albumin is of special interest in that increased permeability to it is an important factor in the pathogenesis of some oedemas, we shall consider the transfer of this protein only. Serum albumin is found mainly, but not entirely within the intravascular space. A certain amount leaks out through the walls of the capillaries, but protein thus 'lost' is returned, mainly by lymphatic resorption and, under normal conditions, a state of equilibrium exists between the overall 'loss' and the overall return. Any upset in this equilibrium which results in a net increase of albumin in the extravascular space will, if gross enough, result in oedema, and although this upset will not necessarily be an increase in capillary permeability, this is one possibility which can be investigated relatively simply.
Navigating Risks and Professional Roles: Research with Lesbian, Gay, Bisexual, Trans, and Queer Young People with Intellectual Disabilities

We examine ethical issues that emerged during a community-based participatory research (CBPR) study in Toronto, Canada, exploring sexual health attitudes and practices among lesbian, gay, bisexual, trans, queer, and questioning (LGBTQ) young people (ages 17–26) labeled with intellectual disabilities. These ethical concerns included: (1) managing the risk of coercion, (2) consent to participate in the study, (3) issues of confidentiality and disclosure, (4) balancing beneficence with self-determination, and (5) role conflict for researcher-practitioners who participate in CBPR projects. Incorporating critical disability perspectives and a heightened awareness of professional role conflict into CBPR practices has the potential to foster development of more inclusive and accessible sexual health initiatives and research environments.
Cohort Profile: the Australian Longitudinal Study on Women's Health.

major aspects of women’s health and well-being and health service use. The surveys cover major diagnosed diseases, symptoms, health behaviours, use of health services and medications, and a range of factors relating to psychological well-being, social roles, and life events. The study began with the objective of exploring five key themes: health service use; health-related behaviours (e.g. diet and exercise); time use (paid work, unpaid work, and leisure); life stages and key events (e.g. childbirth, divorce, and widowhood); and violence against women. 4 Changes in Australian government policy priorities and enhanced understanding of women’s needs resulting from earlier phases of the study have led to some modifications to the original emphases. Currently we identify four major research topics: chronic disease; health services and systems; social factors in health and well-being; and methodology for longitudinal studies. Continuing cross-cutting themes include rural and remote women’s health; intergenerational issues; tobacco, alcohol, and other drugs; weight, nutrition, and physical activity; and mental health.
HiKV: A Hybrid Index Key-Value Store for DRAM-NVM Memory Systems

Hybrid memory systems consisting of DRAM and Non-Volatile Memory are promising to persist data fast. The index design of existing key-value stores for hybrid memory fails to utilize its specific performance characteristics: fast writes in DRAM, slow writes in NVM, and similar reads in DRAM and NVM. This paper presents HiKV, a persistent key-value store with the central idea of constructing a hybrid index in hybrid memory. To support rich key-value operations efficiently, HiKV exploits the distinct merits of hash index and B+-Tree index. HiKV builds and persists the hash index in NVM to retain its inherent ability of fast index searching. HiKV builds the B+-Tree index in DRAM to support range scan and avoids long NVM writes for maintaining consistency of the two indexes. Furthermore, HiKV applies differential concurrency schemes to hybrid index and adopts ordered-write consistency to ensure crash consistency. For single-threaded performance, HiKV outperforms the state-of-the-art NVM-based key-value stores by reducing latency up to 86.6%, and for multithreaded performance, HiKV increases the throughput by up to 6.4x under YCSB workloads.
Cognitive and Social Functioning Deficits after Anti-N-Methyl-D-Aspartate Receptor Encephalitis: An Exploratory Case Series

Abstract Background: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently described life-threatening autoimmune disorder associated with a characteristic multi-stage neuropsychiatric syndrome. Although it is known that the majority of patients experience neuropsychological disturbance post-treatment, some aspects of the cognitive profile remain unclear. Methods: This study sought to investigate patterns of cognitive functioning in a sample of anti-NMDAR encephalitis patients. Seven (6F:1M; mean age, 26.4 years; range, 16–37 years) treated patients completed a comprehensive set of neurocognitive and social functioning measures. Performance was analyzed using normative data (where available), and comparison with matched controls (10F:4M; mean age, 25.8 years; range, 16–38 years). Results: Individual cognitive profiles ranged from within normal limits to extensive dysfunction. Relative to controls, the patient group’s performance was affected in the domains of verbal/ visual memory, working memory, attention, processing speed, executive functioning, and social cognition. The patient group also reported significantly higher levels of anxiety compared to controls. Conclusions: These results add to the accumulating evidence that neurocognitive deficits, consistent with the distribution and functions of the NMDAR system can persist during recovery from anti-NMDAR encephalitis. This is the first study to provide evidence of performance decrements on measures of social cognition, including some involving theory of mind. (JINS, 2016, 22, 828–838)
Hemolysis after Mitral Valve Repair

Hemolysis is a potential complication of mitral valve repair. We report a case of hemolytic anemia after mitral valve repair successfully treated with re‐repair, and review the literature on reoperation after failure of mitral valve repair with associated hemolysis. doi: 10.1111/jocs.12060 (J Card Surg 2013;28:129–132)
Monte Carlo model for electron degradation in xenon gas

We have developed a Monte Carlo model for studying the local degradation of electrons in the energy range 9–10 000 eV in xenon gas. Analytically fitted form of electron impact cross sections for elastic and various inelastic processes are fed as input data to the model. The two-dimensional numerical yield spectrum (NYS), which gives information on the number of energy loss events occurring in a particular energy interval, is obtained as the output of the model. The NYS is fitted analytically, thus obtaining the analytical yield spectrum (AYS). The AYS can be used to calculate electron fluxes, which can be further employed for the calculation of volume production rates. Using the yield spectrum, mean energy per ion pair and efficiencies of inelastic processes are calculated. The value for mean energy per ion pair for Xe is 22 eV at 10 keV. Ionization dominates for incident energies greater than 50 eV and is found to have an efficiency of approximately 65% at 10 keV. The efficiency for the excitation process is approximately 30% at 10 keV.
Child care subsidies and the employment of welfare recipients

Changing patterns of maternal employment, coupled with stronger work requirements for welfare recipients, are increasing the demand for child care. For many families, the cost of child care creates a financial burden; for mothers with low incomes and those who are former welfare recipients, these costs may be an insurmountable barrier to employment or economic self-sufficiency. Despite increased public spending in this area, the receipt of any child care subsidy appears to be a relatively rare and uncertain event. In this study, we use data from a sample of low-income single mothers (current and recent welfare recipients in California) to estimate the probability of their receiving child care subsidies and the effect of this probability on labor market activity.
Identification and Characterization of a Type III Polyketide Synthase Involved in Quinolone Alkaloid Biosynthesis from Aegle marmelos Correa*

Background: Type III polyketide synthase is hypothesized to produce quinolones, but no such enzyme has been identified so far. Results: QNS, a type III PKS from Aegle marmelos synthesizes diketide 4-hydroxy-1-methyl-2H-quinolone using a unique substrate binding site. Conclusion: QNS is a novel 4-hydroxy-1-methyl-2H-quinolone synthase. Significance: This is the first report of a gene involved in quinolone biosynthesis from plants. Quinolone alkaloids, found abundantly in the roots of bael (Aegle marmelos), possess various biological activities and have recently gained attention as potential lead molecules for novel drug designing. Here, we report the characterization of a novel Type III polyketide synthase, quinolone synthase (QNS), from A. marmelos that is involved in the biosynthesis of quinolone alkaloid. Using homology-based structural modeling, we identify two crucial amino acid residues (Ser-132 and Ala-133) at the putative QNS active site. Substitution of Ser-132 to Thr and Ala-133 to Ser apparently constricted the active site cavity resulting in production of naringenin chalcone from p-coumaroyl-CoA. Measurement of steady-state kinetic parameters demonstrates that the catalytic efficiency of QNS was severalfold higher for larger acyl-coenzymeA substrates as compared with smaller precursors. Our mutagenic studies suggest that this protein might have evolved from an evolutionarily related member of chalcone synthase superfamily by mere substitution of two active site residues. The identification and characterization of QNS offers a promising target for gene manipulation studies toward the production of novel alkaloid scaffolds.
An Ambient Assisted Living Framework Supporting Personalization Based on Ontologies

—As the population in many countries is steadily aging, allowing elderly people to stay longer at home is a growing concern. Ambient Assisted Living (AAL) proposes new techniques to help people remain autonomous, based on ambient intelligence. We present an ontology-based framework in which ontologies enable the expression of users’ preferences in order to personalize the system behavior. They are also used for the discovery and interconnection of devices, the storage and retrieval of collected data and the transmission of actions. This way, the behavior of the system may be expressed using high-level logic rules. Another important contribution is the addition of a diagnosis service that monitors the run-time behavior of the AAL system only by using sensors discovered opportunistically at run-time and knowledge about physical laws, not pre-deﬁned control loops. Finally, this paper describes an actual implementation, with precise technological details, in order to prove the feasibility of the technical choices, and provide implementation ideas for future projects.
Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1

Lipoproteins or lipopeptides (LP) are bacterial cell wall components detected by the innate immune system. For LP, it has been shown that TLR2 is the essential receptor in cellular activation. However, molecular mechanisms of LP recognition are not yet clear. We used a FLAG‐labeled derivative of the synthetic lipopeptide N‐palmitoyl‐S‐[2,3‐bis(palmitoyloxy)‐(2R,S)‐propyl]‐(R)‐cysteinyl‐seryl‐(lysyl)3‐lysine (Pam3CSK4) to study the roles of CD14, TLR2 and TLR1 in binding and signaling of LP and their molecular interactions in human cells. The activity of Pam3CSK4‐FLAG was TLR2 dependent, whereas the binding was enabled by CD14, as evaluated by flow cytometry and confocal microscopy. Using FRET and FRAP imaging techniques to study molecular associations, we could show that after Pam3CSK4‐FLAG binding, CD14 and Pam3CSK4‐FLAG associate with TLR2 and TLR1, and TLR2 is targeted to a low‐mobility complex. Thus, LP binding to CD14 is the first step in the LP recognition, inducing physical proximity of CD14 and LP with TLR2/TLR1 and formation of the TLR2 signaling complex.
Have you met your organization's computer usage policy?

Purpose – This paper aims to examine the effectiveness of computer usage policies in university settings.Design/methodology/approach – Students enrolled in business courses at three midwestern universities were divided, by class, into control and experimental groups. All subjects were asked to complete a survey regarding their awareness of university computer usage policies, consequences of misuse, and methods of policy distribution. The experimental group was exposed to sample computer usage policies. Two weeks later, all subjects were asked to complete the same survey again.Findings – Results suggest that most students have not read their university computer usage policies. However, the presence of a computer usage policy does influence students who have read those policies, but a single exposure is insufficient to influence all subjects.Research limitations/implications – The sample is limited to students from three universities.Practical implications – Written policy statements alone cannot serve as a.
Keys for successful implementation of total quality management in hospitals

Editor’s Note: This article reports the findings of an analysis of the implementation of continuous quality improvement (CQI) or total quality management (TQM) programs in 10 hospitals. This analysis is the result of a 2-year study designed to identify and assess the ingredients that lead to the successful implementation of CQI programs in acute care hospitals. This article first appeared in Health Care Management Review 21(1), 48–60. Copyright A 1996 Aspen Publishers, Inc. (Lippincott Williams & Wilkins).
Tradeoff between client and server transaction validation in mobile environment

With the rapid proliferation of mobile devices and services, efficient support for mobile transactions has become extremely important. As locking based pessimistic approaches to concurrency control have been known to be not very suitable for the mobile environment, many optimistic concurrency control schemes have been proposed to date, of which the broadcast certification based approach is of special interest because of its simplicity and its efficient use of the downlink bandwidth. The authors propose modifications to the broadcast certification based protocol and show, using simulation results, how useful tradeoffs can be obtained between client side and server side validation, resulting in optimal performance.