Miracle-dz/UniFAR-FTUs huggingface dataset:
A Condom Skill Scale: Assessing Condom Skills among Female Drug Users

Use of latex condoms is a primary form of sexual risk reduction, and consequently many intervention programs have focused efforts on increasing condom use among high-risk populations. Use alone, however, will not fully protect the individual if condoms are not used correctly. The objective of this study was to describe the development and properties of a scale measuring demonstrated condom use skill using a sample of 261 drug-using women. Guttman's coefficient of reproducibility and Jackson's Plus Percentage Ratio (PPR) were used to determine the scalability of the Condom Skill Scale (CSS). Analysis of scale scores revealed high levels of condom skill among the population, although there was reduced performance for three items. Preliminary analysis suggests that the CSS is a potentially valid and reliable instrument, and may have application as a tool assessing condom skill level.
The compatibility analysis of thread migration and DVFS in multi-core processor

Integrating multiple cores into a processor increases the heat density significantly, which often constrains the maximum performance of such a processor. There have been many techniques using dynamic voltage and frequency scaling (DVFS) and thread migration to manipulate heat dissipation in thermally-constrained multi-core processors. However, most of them were analyzed and applied individually for optimizing the performance of the multi-core processors while their computational cost for the optimization was not studied well. In this paper, we argue that a coherent organization of two techniques can maximize the performance of the multi-core processors with the least performance overheads associated with the thermal management techniques. Furthermore, we also propose an efficient method to optimize the performance of thermal-constrained multi-core processors. According to our experiment, we achieved 5% throughput improvement with negligible computation cost.
Evaluation of air-displacement plethysmography in children aged 5-7 years using a three-component model of body composition

The aim of the present study was to evaluate air-displacement plethysmography (ADP) in children aged 5–7 years. Body-composition measurements were obtained by ADP, 2H dilution and anthropometry in twenty-eight children. Calculation of body volume by ADP was undertaken using adult and children's equations for predicting lung volume and surface area. Fat-free mass (FFM) was calculated using a three-component model. Measured FFM hydration was then compared with values from the reference child. Differences between measured and reference hydration were back-extrapolated, to calculate the error in ADP that would account for any disagreement. Propagation of error was used to distinguish the contributions of methodological precision and biological variability to total hydration variability. The use of children's equations influenced the results for lung volume but not surface area. The mean difference between measured and reference hydration was 0·6 (sd 1·7) % (P < 0·10), equivalent to an error in body volume of 0·04 (sd 0·20) litres (P < 0·30), and in percentage fat of 0·4 (sd 1·9) (P < 0·28). The limits of agreement in individuals could be attributed to methodological precision and biological variability in hydration. It is concluded that accuracy of ADP was high for the whole group, with a mean bias of < 0·5 % fat using the three-component model, and after taking into account biological variability in hydration, the limits of agreement were around ±2% fat in individuals. Paediatric rather than adult equations for lung volume estimation should be used.
FC Portugal 2006 Rescue Team Description: Coordination and Learning Methodologies in the Search and Rescue Domain

FC Portugal Rescue team is the result of a cooperation project between the Universities of Aveiro and Porto in Portugal. The project started in January 2004 following previous collaborations of these two Portuguese Universities in RoboCup simulation league and associated competitions: coach competition, simulation league presentation competition and simulation 3D competition. FC Portugal Rescue project intends to fully adapt the coordination methodologies developed by FC Portugal simulated soccer team to the search and rescue scenario. The project is also focused on applying learning methodologies to high-level strategic decisions. After FC Portugal first successful participation in RoboCup rescue simulation league (Osaka, 2005), the team aimed at introducing new high-level strategic analysis tools in the Rescue league and developed FCPx. This tool enables to easily compare different rescue teams’ strategies. It also enables the use of learning methodologies for high-level strategic decisions in rescue teams.
Ionic mechanisms and Ca2+ dynamics underlying the glucose response of pancreatic β cells: a simulation study

To clarify the mechanisms underlying the pancreatic β-cell response to varying glucose concentrations ([G]), electrophysiological findings were integrated into a mathematical cell model. The Ca2+ dynamics of the endoplasmic reticulum (ER) were also improved. The model was validated by demonstrating quiescent potential, burst–interburst electrical events accompanied by Ca2+ transients, and continuous firing of action potentials over [G] ranges of 0–6, 7–18, and >19 mM, respectively. These responses to glucose were completely reversible. The action potential, input impedance, and Ca2+ transients were in good agreement with experimental measurements. The ionic mechanisms underlying the burst–interburst rhythm were investigated by lead potential analysis, which quantified the contributions of individual current components. This analysis demonstrated that slow potential changes during the interburst period were attributable to modifications of ion channels or transporters by intracellular ions and/or metabolites to different degrees depending on [G]. The predominant role of adenosine triphosphate–sensitive K+ current in switching on and off the repetitive firing of action potentials at 8 mM [G] was taken over at a higher [G] by Ca2+- or Na+-dependent currents, which were generated by the plasma membrane Ca2+ pump, Na+/K+ pump, Na+/Ca2+ exchanger, and TRPM channel. Accumulation and release of Ca2+ by the ER also had a strong influence on the slow electrical rhythm. We conclude that the present mathematical model is useful for quantifying the role of individual functional components in the whole cell responses based on experimental findings.
Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

A dynamic balance of organelle fusion and fission regulates mitochondrial morphology. During apoptosis this balance is altered, leading to an extensive fragmentation of the mitochondria. Here, we describe a novel assay of mitochondrial dynamics based on confocal imaging of cells expressing a mitochondrial matrix–targeted photoactivable green fluorescent protein that enables detection and quantification of organelle fusion in living cells. Using this assay, we visualize and quantitate mitochondrial fusion rates in healthy and apoptotic cells. During apoptosis, mitochondrial fusion is blocked independently of caspase activation. The block in mitochondrial fusion occurs within the same time range as Bax coalescence on the mitochondria and outer mitochondrial membrane permeabilization, and it may be a consequence of Bax/Bak activation during apoptosis.
The Effects of Positive Cognitions on the Relationship between Alienation and Resourcefulness in Nursing Students in Egypt

Alienation is a subjective state, a feeling of being a stranger, as if one were not one's normal self. It is also a sense of homelessness; a feeling of uneasiness or discomfort, which signifies the person's exclusion from social or cultural participation. Alienation can adversely affect healthy functioning of nursing students. Nursing students are the adolescents of today and the nurses of tomorrow who will deal with human behavior, and their psychological well-being will be important in managing their clients’ conditions. Healthy nursing students are likely to become healthy nurses who can then model and promote healthy lifestyles for their patients. This study looked at whether the effects of alienation on adolescents’ resourcefulness are influenced by positive cognitions. Zauszniewski's theory of resourcefulness, which is based on the conceptualization of two forms of resourcefulness: personal (self-help) and social (help-seeking) resourcefulness, served as the theoretical framework for the study. A descriptive, correlational, cross-sectional design was used to examine hypothesized relationships among the study variables in a convenience sample of 170 first-year nursing students aged 17 to 20 years. Results showed that positive cognitions had a moderating and a partial mediating effect on the relationship between alienation and resourcefulness. It is imperative for nurse educators to generate interventions to enhance positive cognitions among nursing students.
Nitric oxide involvement in the antidepressant-like effect of ketamine in the Flinders sensitive line rat model of depression

Objective We investigated whether the nitric oxide (NO) precursor, l-arginine, can prevent the antidepressant-like action of the fast-acting antidepressant, ketamine, in a genetic rat model of depression, and/or induce changes in the glutamate (Glu)/N-methyl-d-aspartate receptor (NMDAR)/NO/cyclic guanosine monophosphate (cGMP) signalling pathway. Hereby it was evaluated whether the NO signalling system is involved in the antidepressant mechanism of ketamine. Methods Flinders sensitive line (FSL) rats received single i.p. injections of ketamine (15 mg/kg) with/without pre-treatment (30 min prior) with l-arginine (500 mg/kg). Depression-like behaviour was assessed in the forced swim test (FST) in terms of immobility, and the activation state of the Glu/NMDAR/NO/cGMP pathway was evaluated ex vivo in the frontal cortex and hippocampus regions in terms of total constitutive NOS (cNOS) activity and cGMP concentration. Results l-Arginine pre-treatment prevented the antidepressant-like effect of ketamine in the FST, as well as a ketamine-induced increase in cGMP levels in the frontal cortex and hippocampus of FSL rats. Ketamine reduced cNOS activity only in the hippocampus, and this effect was not reversed by l-arginine. Conclusion Both the behavioural and molecular results from this study indicate an involvement for the NO signalling pathway in the antidepressant action of ketamine. Although not easily interpretable, these findings broaden our knowledge of effects of ketamine on the NO system.
Incorporation of mineralogical composition into models of the radiative properties of mineral aerosol from UV to IR wavelengths

We describe a technique to model the radiative properties of mineral aerosols which accounts for their composition. We compile a data set of refractive indices of major minerals and employ it, along with data on mineralogical composition of dust from various locations, to calculate spectral optical and radiative properties of mineral aerosol mixtures. Such radiative properties are needed for climate modeling and remote sensing applications. We consider external mixtures of individual minerals, as well as mixtures of aggregates. We demonstrate that an external mixture of individual minerals must contain unrealistically high amounts of hematite to have a single scattering albedo lower than 0.9 at 500 nm wavelength. In contrast, aggregation of hematite with quartz or clays can strongly enhance absorption by dust at solar wavelengths. We also simulate the daily mean net (solar + infrared) forcing by dust of varying compositions. We found that, for a given composition and under similar atmospheric conditions, a mixture of aggregates can cause the positive radiative forcing while a mixture of individual minerals gives the negative forcing.
Luminescence and radiocarbon dating as tools for the recognition of extraterrestrial impacts

Extraterrestrial events and the extraterrestrial origin of both material and impact forms were recognized in the Morasko, Kaali and Przełazy shallow geological profiles by means of luminescence and radiocarbon dating as well as the frequency of magnetic spherules. The obtained results provide a promising tool for proving theat extraterrestrial events affected characteristic lithological and morphological environmental features.
Stress and crustal anisotropy in Marlborough, New Zealand: evidence for low fault strength and structure‐controlled anisotropy

SUMMARY The major strike-slip faults in the greater Marlborough region, central New Zealand, are of both scientific and societal interest as they accommodate relative plate motion in the upper plate of an oblique subduction zone and pose a high seismic risk to central New Zealand. Studies in California suggest that some plate-bounding strike-slip faults are frictionally weak and that crustal anisotropy is controlled by the ambient stress. Whether these observations are more generally applicable to major strike-slip faults has yet to be determined. We have used inversions of focal mechanism and first motion data to calculate the principal stress directions in Marlborough and related them to the geometry of the major faults. The average angle between the axis of maximum horizontal compressive stress (S Hmax) and the average strike of the major faults is 60 ◦ ; this is substantially higher than the ∼30 ◦ expected for reactivation of av ertical strike-slip fault given Byerlee friction and hydrostatic fluid pressure. This geometry can be explained, however, by the faults having a moderately low friction coefficient (∼0.35), a moderately high fluid pressure (∼0.7 × lithostatic) or some combination of the two. This observation substantiates the hypothesis that the San Andreas fault is not unique in being frictionally weak. We have also conducted shear-wave splitting analysis on local S phases to determine the directions of crustal anisotropy and investigated their orientations with respect to the geological fabric and the principal stress directions. The anisotropy determined using shallow earthquakes reveals that the fast direction is 65 ± 50 ◦ and is generally aligned with the NE‐SW-striking faults, and we therefore conclude that crustal anisotropy in Marlborough is controlled more by the geological structures than by the prevailing stress field.
The hyper-sentient addict: an exteroception model of addiction

Abstract Background: Exteroception involves processes related to the perception of environmental stimuli important for an organism’s ability to adapt to its environment. As such, exteroception plays a critical role in conditioned response. In addiction, behavioral and neuroimaging studies show that the conditioned response to drug-related cues is often associated with alterations in brain regions including the precuneus/posterior cingulate cortex, an important node within the default mode network dedicated to processes such as self-monitoring. Objective: This review aimed to summarize the growing, but largely fragmented, literature that supports a central role of exteroceptive processes in addiction. Methods: We performed a systematic review of empirical research via PubMed and Google Scholar with keywords including ‘addiction’, ‘exteroception’, ‘precuneus’, and ‘self-awareness’, to identify human behavioral and neuroimaging studies that report mechanisms of self-awareness in healthy populations, and altered self-awareness processes, specifically exteroception, in addicted populations. Results: Results demonstrate that exteroceptive processes play a critical role in conditioned cue response in addiction and serve as targets for interventions such as mindfulness training. Further, a hub of the default mode network, namely, the precuneus, is (i) consistently implicated in exteroceptive processes, and (ii) widely demonstrated to have increased activation and connectivity in addicted populations. Conclusion: Heightened exteroceptive processes may underlie cue-elicited craving, which in turn may lead to the maintenance and worsening of substance use disorders. An exteroception model of addiction provides a testable framework from which novel targets for interventions can be identified.
A Novel Oncolytic Herpes Simplex Virus Type 2 Has Potent Anti-Tumor Activity

Oncolytic viruses are promising treatments for many kinds of solid tumors. In this study, we constructed a novel oncolytic herpes simplex virus type 2: oHSV2. We investigated the cytopathic effects of oHSV2 in vitro and tested its antitumor efficacy in a 4T1 breast cancer model. We compared its effect on the cell cycle and its immunologic impact with the traditional chemotherapeutic agent doxorubicin. In vitro data showed that oHSV2 infected most of the human and murine tumor cell lines and was highly oncolytic. oHSV2 infected and killed 4T1 tumor cells independent of their cell cycle phase, whereas doxorubicin mainly blocked cells that were in S and G2/M phase. In vivo study showed that both oHSV2 and doxorubicin had an antitumor effect, though the former was less toxic. oHSV2 treatment alone not only slowed down the growth of tumors without causing weight loss but also induced an elevation of NK cells and mild decrease of Tregs in spleen. In addition, combination therapy of doxorubicin followed by oHSV2 increased survival with weight loss than oHSV2 alone. The data showed that the oncolytic activity of oHSV2 was similar to oHSV1 in cell lines examined and in vivo. Therefore, we concluded that our virus is a safe and effective therapeutic agent for 4T1 breast cancer and that the sequential use of doxorubicin followed by oHSV2 could improve antitumor activity without enhancing doxorubicin’s toxicity.
Fast Distance Field Interpolation for Reconstruction of Surfaces from Contours

One simple and robust way to get a reconstruction of surfaces from a given contour stack dealing well with branching and other problems which are generally difficult to solve is based on the well known MC-algorithm. To overcome the staircase artefacts produced by the MC-algorithm Jones et. al. 3 proposed to use a distance field interpolation between the slices and to run the MC-algorithm on this distance field. The main problem of this approach is the distance field computation as it is very time consuming especially if high resolution grids (e.g. 1024 1024 are used. Therefore, in the original algorithm the resolution of the chosen grid is much less than the resolution of the given contour sacrificing accuracy of the resulting surface. Especially in medical applications this is not accepted by the doctors. In this paper we introduce a new method for the computation of the discrete distance field, which is a breaktrough in terms of speed and accuracy. This new method allows us to reconstruct surfaces from contour stacks with guaranteed accuracy in reasonable time. Several examples show the power of this approach.
Quercetin/β-Cyclodextrin Solid Complexes Prepared in Aqueous Solution Followed by Spray-drying or by Physical Mixture

The present study was designed to investigate the influence of operating conditions (temperature, stirring time, and excess amount of quercetin) on the complexation of quercetin with β-cyclodextrin using a 23 factorial design. The highest aqueous solubility of quercetin was reached under the conditions 37°C/24 h/6 mM of quercetin. The stoichiometric ratio (1:1) and the apparent stability constant (Ks = 230 M−1) of the quercetin/β-cyclodextrin complex were determined using phase-solubility diagrams. The semi-industrial production of a 1:1 quercetin/β-cyclodextrin solid complex was carried out in aqueous solution followed by spray-drying. Although the yield of the spray-drying process was adequate (77%), the solid complex presented low concentration of quercetin (0.14%, w/w) and, thus, low complexation efficiency. The enhancement of aqueous solubility of quercetin using this method was limited to 4.6-fold in the presence of 15 mM of β-cyclodextrin. Subsequently, an inclusion complex was prepared via physical mixture of quercetin with β-cyclodextrin (molar ratio of 1:1 and quercetin concentration of 23% (w/w)) and characterized using infrared spectroscopy, differential scanning calorimetry, nuclear magnetic resonance spectroscopy, and scanning electron microscopy analyses. The enhancement of aqueous solubility of quercetin using this method was 2.2-fold, similar to that found in the complex prepared in aqueous solution before the spray-drying process (2.5-fold at a molar ratio of 1:1, i.e., 6 mM of quercetin and 6 mM of β-cyclodextrin).
Therapeutic potential of new antiinflammatory drugs

Experimental and clinical findings have shown in the past decade that specific proinflammatory mediators and their cognate receptors are upregulated in epileptic brain tissue. In particular, the IL‐1 receptor (R)/Toll‐like receptor (TLR) signaling pathways are activated in experimental models of seizures and in human epileptic tissue from drug‐resistant patients. Pharmacological targeting of these proinflammatory pathways using selective receptor antagonists, or the use of transgenic mice with perturbed cell signaling, demostrated that the activation of IL‐1R type 1 and TLR4 by their respective endogenous ligands, i.e., interleukin (IL)‐1b and High Mobility Group Box 1, is implicated in the precipitation and recurrence of experimentally induced seizures in rodents. This evidence highlights a new target system for pharmacological intervention to inhibit seizures by interfering with mechanisms involved in their genesis and recurrence.
GB: A New Grid-Based Binding Approach for High-Level Synthesis

This paper describes a new approach to connectivity binding for high-level synthesis, The new approach is based on deriving geometric communication information from a state graph. The derived information is used to produce bindings that lead to efficient communication structures in the final layouts. It is important because routing may account for a significant portion of the layout area and long communication lines tend to lead to longer machine state cycle times. It becomes even more critical us feature sizes are reduced. The heuristics in this paper use a new grid-based binding approach that produces quulity results on the commonly run benchmarks in only a few tenths of a second of CPU time on a Sun 41490. The work presented in [his paper also has an impact on research in partitioning and in bringing useful information from higher levels of abstraction down to final layout.
Cross-Cultural Consumer Behavior: A Review of Research Findings

ABSTRACT Most aspects of consumer behavior are culture-bound. This article reviews the cultural relationships with the self, personality, and attitude, which are the basis of consumer behavior models and branding and advertising strategies. The Hofstede model is used to explain variance. Other consumer behavior aspects reviewed are motivation and emotions, cognitive processes such as abstract versus concrete thinking, categorization and information processing, as well as consumer behavior domains such as product ownership, decision making, and adoption and diffusion of innovations. Implications for global branding and advertising are included.