Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence and risk of hypertension with bevacizumab in non-small-cell lung cancer patients: a meta-analysis of randomized controlled trials

Aim A study was conducted to determine the overall risk and incidence of hypertension with bevacizumab in non-small-cell lung cancer (NSCLC) patients. Materials and methods Electronic databases such as the Embase, PubMed, and Cochrane Library were searched for related trials. Statistical analyses were conducted to calculate the overall incidence rates, odds ratios (ORs), and 95% confidence intervals (CIs) by using either random-effect or fixed-effect models depending on the heterogeneity. Results A total of 3,155 subjects from nine studies were included. The overall incidences of all-grade and high-grade hypertension in NSCLC patients were 19.55% (95% CI 10.17%–34.3%) and 6.95% (95% CI 5.81%–8.30%). Bevacizumab use was associated with a significantly increased risk in all-grade hypertension (OR 8.07, 95% CI 3.87–16.85; P=0.0002) and high-grade hypertension (OR 5.93, 95% CI 3.41–10.32; P<0.0001). No evidence of publication bias was determined for the ORs of hypertension in our meta-analysis. Conclusion Bevacizumab is associated with a significantly increased risk of hypertension development in NSCLC patients. Early monitoring and effective management of hypertension might be important steps for the safe use of this drug.
Endoscopy-assisted wide-vertex craniectomy, barrel stave osteotomies, and postoperative helmet molding therapy in the management of sagittal suture craniosynostosis.

OBJECT Endoscopic techniques were introduced 7 years ago for the surgical management of patients with sagittal synostosis. In this study of 139 patients with sagittal synostosis, the authors assessed the efficacy, safety, complications, and outcomes after performing endoscopy-assisted wide-vertex craniectomies with bitemporal and biparietal barrel stave osteotomies. METHODS The sample population consisted of a total of 99 boys and 40 girls who ranged in age from 0.4 to 9.2 months (mean 3.6 months). Two small incisions were made near the lambda and vertex. Using endoscopic visualization, wide-vertex craniectomies with bilateral temporal and parietal barrel stave osteotomies were performed. Postoperative treatment included custom-made surlyn cranial orthotic devices for cranial reshaping and maintenance. The mean craniectomy width was 5.4 cm and the length was 10 cm. The overall blood transfusion rate was 9% (two intraoperative and 12 postoperative transfusions). The mean estimated blood loss was 29 ml (range 5-150 ml). The mean preoperative hematocrit was 32%, whereas the postoperative level was 27%. One hundred thirty-two patients were discharged the morning following surgery. The majority of patients did not experience facial swelling, and none suffered postoperative fevers. Anthropometric cephalic index measurements indicated that excellent results were obtained in 87% of the patients (cephalic index > 75); good results in 8.7% (cephalic index 70-75); and poor results in 4.3% (cephalic index > 70). There were no cases of intraoperative death, infection, hemorrhage, or venous sinus injury. CONCLUSIONS Analysis of the results indicates that use of the aforedescribed procedure in the early treatment of infants with sagittal synostosis provides excellent outcomes and that the morbidity rate is lower than that associated with traditional cranial vault reconstruction. Detailed anthropometric and radiographic analyses demonstrated that with adequate helmet therapy in our patients normocephaly was achieved and maintained without the need for secondary operations.
The family report perceived the adolescents through millon adolescent personality inventory (M.A.P.I.)

Este estudio tiene como objetivo la influencia que la familia tiene en el adolescente a traves de un test conocido como Inventario Adolescente de la Personalidad de Millon (M.A.P.I.). La muestra se compone de 319 adolescentes espanoles, entre 13 y 18 anos (inclusives), divididos en grupos de edades (13-15 y 16-18 anos) y de ambos sexos. Perciben su entorno familiar no muy gratificante para su desarrollo, no estan satisfechos con sus obligaciones escolares, son poco respetuosos, emocionalmente fragiles y con dificultades para controlar sus impulsos.
Large-n expansion for m-axial Lifshitz points

The large-n expansion is developed for the study of critical behaviour of d-dimensional systems at m-axial Lifshitz points with an arbitrary number m of modulation axes. The leading nontrivial contributions to O (1/n) are derived for the two independent correlation exponents ηL2 and ηL4, and the related anisotropy index θ. The series coefficients of these 1/n corrections are given for general values of m and d with 0≤m≤d and 2+m/2<d<4+m/2 in the form of integrals. For special values of m and d such as (m,d) = (1,4), they can be computed analytically, but in general their evaluation requires numerical means. The 1/n corrections are shown to reduce in the appropriate limits to those of known large-n expansions for the case of d-dimensional isotropic Lifshitz points and critical points, respectively, and to be in conformity with available dimensionality expansions about the upper and lower critical dimensions. Numerical results for the 1/n coefficients of ηL2, ηL4 and θ are presented for the physically interesting case of a uniaxial Lifshitz point in three dimensions, as well as for some other choices of m and d. A universal coefficient associated with the energy-density pair correlation function is calculated to leading order in 1/n for general values of m and d.
The Effect of Electrospun Gelatin Fibers Alignment on Schwann Cell and Axon Behavior and Organization in the Perspective of Artificial Nerve Design

Electrospun fibrous substrates mimicking extracellular matrices can be prepared by electrospinning, yielding aligned fibrous matrices as internal fillers to manufacture artificial nerves. Gelatin aligned nano-fibers were prepared by electrospinning after tuning the collector rotation speed. The effect of alignment on cell adhesion and proliferation was tested in vitro using primary cultures, the Schwann cell line, RT4-D6P2T, and the sensory neuron-like cell line, 50B11. Cell adhesion and proliferation were assessed by quantifying at several time-points. Aligned nano-fibers reduced adhesion and proliferation rate compared with random fibers. Schwann cell morphology and organization were investigated by immunostaining of the cytoskeleton. Cells were elongated with their longitudinal body parallel to the aligned fibers. B5011 neuron-like cells were aligned and had parallel axon growth when cultured on the aligned gelatin fibers. The data show that the alignment of electrospun gelatin fibers can modulate Schwann cells and axon organization in vitro, suggesting that this substrate shows promise as an internal filler for the design of artificial nerves for peripheral nerve reconstruction.
A phase retrieval method for signals in modulation-invariant spaces

This paper considers the problem of signal recovery from magnitude measurements for signals in modulation invariant spaces. It proposes a measurement setup such that almost every signal in such a signal space can be reconstructed from its amplitude measurements up to a global constant phase and with a sampling rate of four times the rate of innovation of the signal space. The applicability of the proposed scheme under noise measurements is demonstrated by computer simulations.
Implementation and Evaluation of an OpenFlow-Based Access Control System for Wireless LAN Roaming

A flexible access control mechanism with user authentication is required for campus wireless LAN roaming. In general, VLAN tagging and firewall are adopted to realize it. However, the scalability of the conventional VLAN mechanism is low for a large system. An OpenFlow-based system was proposed to solve the problem. In this paper, we point out some limitations of the conventional system, and propose a new access control system. We also implement our system and demonstrate that it works correctly with acceptable server load and high usability.
Value and categories in socially constructed authenticity: Empirical tests from on-line restaurant reviews*

This study examines socially constructed authenticity. It first tests a fundamental yet rarely examined assumption underlying the contemporary appeal of authenticity, namely, that consumers assign higher value to organizations perceived as authentic. It also explores how consumers use language to express judgments about different meanings of authenticity. In addition, it examines how such judgments of authenticity vary across certain observers and organizations. The empirical tests use content analysis to scrutinize online restaurant reviews entered voluntarily by consumers in three major US metropolitan areas reviewers of 18,869 restaurants. The findings show that consumers do assign higher ratings to restaurants that are regarded as authentic, even after controlling for restaurant quality; dining enthusiasts also reward authenticity but with less weight. Moreover, consumers convey views about four distinct subtypes of authenticity and they assign value to each subtype. Finally, consumers perceive specialist (single-category) restaurants and family-owned restaurants as more authentic than they do generalist (multiple-category) and chain restaurants.
Building an Ensemble for Software Defect Prediction Based on Diversity Selection

Background: Ensemble techniques have gained attention in various scientific fields. Defect prediction researchers have investigated many state-of-the-art ensemble models and concluded that in many cases these outperform standard single classifier techniques. Almost all previous work using ensemble techniques in defect prediction rely on the majority voting scheme for combining prediction outputs, and on the implicit diversity among single classifiers. Aim: Investigate whether defect prediction can be improved using an explicit diversity technique with stacking ensemble, given the fact that different classifiers identify different sets of defects. Method: We used classifiers from four different families and the weighted accuracy diversity (WAD) technique to exploit diversity amongst classifiers. To combine individual predictions, we used the stacking ensemble technique. We used state-of-the-art knowledge in software defect prediction to build our ensemble models, and tested their prediction abilities against 8 publicly available data sets. Conclusion: The results show performance improvement using stacking ensembles compared to other defect prediction models. Diversity amongst classifiers used for building ensembles is essential to achieving these performance improvements.
A 5 GHz CMOS low noise amplifier with a 3.25 turn spiral inductor for IEEE802.16a

A 5.25-GHz low noise amplifier (LNA), has been proposed for use in a receiver architecture for IEEE 802.16a WMAN. The targeted frequency band is the unlicensed band UN11 5 GHz. The amplifier has been simulated with two different spiral inductor models as Ld. In our spiral inductor model we have improved "the Greenhouse spiral inductor model", then we compare the results with the case when we use the spiral inductor model of the technology. The amplifier achieves voltage gain of 16.4, 19.4 dB with a noise figure of only 1.5, 1.58 dB, the IIP3 is 14, 13.1-dBm and the reverse isolation is about -10.7, -13.2 dB for our spiral inductor model and that of technology, respectively. Using a 0.18 mum CMOS process, the LNA dissipates 7.2 mW from a 1.8 V supply voltage in both cases. In this paper, we present an analysis of the LNA architecture
Rotational properties of vocal tract length difference in cepstral space

In this paper, we prove that the direction of cepstrum vectors strongly depends on vocal tract length and that this dependency is represented as rotation in a cepstrum space. In speech recognition studies, vocal tract length normalization (VTLN) techniques are widely used to cancel ageand gender-difference. In VTLN, a frequency warping is often carried out and it can be modeled as a linear transform in a cepstrum space; ĉ=Ac. In this study, the geometric properties of this transformation matrix A are made clear using n dimensional geometry and it is shown that the matrix can be approximated as rotation matrix. Further, for better approximation, a new method is proposed. Namely, using eigenvalues of A, its quasi-rotational distortion is factorized into multiple true rotation operations and multiple magnification operations. This decomposition resolves the intrinsic ambiguity of the rotation angle based on the inner product, and it describes the detailed geometrical properties of the transformation caused by vocal tract length normalization. Experimental results using real and resynthesized speech samples demonstrate that the difference of cepstrum vectors extracted from different speakers is represented as rotation and magnification, and that the decomposition based on eigenvalues can capture it precisely.
Brassinosteroid signaling and auxin transport are required to establish the periodic pattern of Arabidopsis shoot vascular bundles

The plant vascular system provides transport and support capabilities that are essential for plant growth and development, yet the mechanisms directing the arrangement of vascular bundles within the shoot inflorescence stem remain unknown. We used computational and experimental biology to evaluate the role of auxin and brassinosteroid hormones in vascular patterning in Arabidopsis. We show that periodic auxin maxima controlled by polar transport and not overall auxin levels underlie vascular bundle spacing, whereas brassinosteroids modulate bundle number by promoting early procambial divisions. Overall, this study demonstrates that auxin polar transport coupled to brassinosteroid signaling is required to determine the radial pattern of vascular bundles in shoots.
An efficient model selection for SVM in realworld datasets using BGA and RGA

Supp ort vector machine (SVM) has become one of the most popular machine-learning methods during the last years. The design of an efficient model and the proper adjustment of the SVMs parameters are integral to reducing the testing time and enhancing performance. In this paper, a new bipartite objective function consisted of the sparseness property and generalization performance is proposed. Since the proposed objective function is based on selecting fewer num- bers of the support vectors, the model complexity is reduced while the performance accuracy remains at an acceptable level. Due to the model complexity reduction, the testing time is decreased and the ability of SVM in practical applications is increased Moreover, to prove the performance of the proposed objective function, a comparative study was carried out on the proposed objective function and the conventional objective function, which is only based on the generalization perfor- mance, using the Binary Genetic Algorithm (BGA) and Real-valued vectors GA (RGA). The effectiveness of the proposed cost function is demonstrated based on the results of the comparative study on four real-world datasets of UCI database.
Emergent positional privilege in novel English blends

We present evidence from experiments on novel blend formation showing that adult English speakers have access to constraints that give phonological privilege to heads, nouns, and proper nouns, even though the nonblend phonology provides no evidence that such constraints are generally active in the grammar of English. Our results (i) demonstrate that these positional constraints are universally available; (ii) confirm that the lexical category ‘proper noun’ has the status of a strong position, which has broader implications for the role of lexical categories in positional privilege effects; and (iii) confirm that strong positions based on salience from nonphonetic sources (such as morphosyntactic, semantic, or psycholinguistic salience) participate in position-specific phonological phenomena.
Generalized degrees of freedom of the symmetric gaussian interference channel with partial unidirectional transmitter cooperation

We consider a two-user symmetric Gaussian Interference Channel (IC), in which one encoder is connected to the other by a unidirectional orthogonal cooperative link with specific capacity. In this setup, we employ a simplified Han-Kobayashi scheme used in [1], along with cooperative communication. We characterize the generalized degrees of freedom [1] of the channel for interference-limited regimes by comparing the achievable sum-rate with some existing upper bounds and also with a new upper bound, introduced in this paper. In particular, we express the number of degrees of freedom available for communication as a function of the interference-to-noise ratio and the multiplexing gain of the cooperative link. In addition, we give the sum-capacity of the channel for the strong interference regime when the capacity of the cooperative link is large enough in terms of the channel parameters. Finally, we show that for noise-limited regimes, treating interference as noise and not using the cooperative link, offer a sum-rate that is at most one bit less than the sum-capacity of the channel.
Isokinetic Strength Responses to Season-long Training and Competition in Turkish Elite Soccer Players

Isokinetic Strength Responses to Season-long Training and Competition in Turkish Elite Soccer Players There are not enough studies that describe the isokinetic strength of professional soccer players at high angular velocities. The purpose of this study was to evaluate the seasonal changes in isokinetic strength of Turkish professional soccer players (n=14) over the course of a 24-week soccer season. The isokinetic strength of players who underwent usual soccer training and weekly competition throughout the soccer season was assessed by means of the Biodex System 3 dynamometer with the knee attachment. The peak torque of knee extensor and flexor muscles were measured at angular velocities of 60°/s, 300°/s and 500°/s. Players were tested at the beginning and end of the competitive season. While the first- and second-test measurements did not show significant changes at 60°/s and 300°/s angular velocities, at the end of the training period, players' knee strength changed significantly at 500°/s angular velocities. In addition, the H/Q ratio improved significantly for the dominant as well as non-dominant leg at 500°/s. Significant bilateral strength improvements for knee flexors were also observed at 500°/s. The findings of this study suggest that usual daily soccer training (technical, tactical, power, strength, endurance, flexibility, etc.) and weekly competition might produce changes in knee strength at high angular velocities.
The Disease Resistance Signaling Components EDS1 and PAD4 Are Essential Regulators of the Cell Death Pathway Controlled by LSD1 in Arabidopsis

Specific recognition of pathogens is mediated by plant disease resistance (R) genes and translated into a successful defense response. The extent of associated hypersensitive cell death varies from none to an area encompassing cells surrounding an infection site, depending on the R gene activated. We constructed double mutants in Arabidopsis between positive regulators of R function and a negative regulator of cell death, LSD1, to address whether genes required for normal R function also regulate the runaway cell death observed in lsd1 mutants. We report here that EDS1 and PAD4, two signaling genes that mediate some but not all R responses, also are required for runaway cell death in the lsd1 mutant. Importantly, this novel function of EDS1 and PAD4 is operative when runaway cell death in lsd1 is initiated through an R gene that does not require EDS1 or PAD4 for disease resistance. NDR1, another component of R signaling, also contributes to the control of plant cell death. The roles of EDS1 and PAD4 in regulating lsd1 runaway cell death are related to the interpretation of reactive oxygen intermediate–derived signals at infection sites. We further demonstrate that the fate of superoxide at infection sites is different from that observed at the leading margins of runaway cell death lesions in lsd1 mutants.
Designing Entrepreneurship Experiments

This article discusses the current and potential application of experimental methods to the study of entrepreneurship phenomena. Drawing on a review of experimental studies in entrepreneurship research, we discuss the advantages and disadvantages of experimental research designs for entrepreneurship research as a primer for those interested but not overly familiar with these methods. To advance research agendas and theory in the field, we introduce a typology of experimental manipulations that highlight alternative design choices based on the nature of their participant impact and realism of context. Finally, we provide an overview of areas of opportunity within the entrepreneurship literature for application of methods best suited to provide greater insight into the causal mechanisms at play.
Toward virtualizing branch direction prediction

This work introduces a new branch predictor design that increases the perceived predictor capacity without increasing its delay by using a large virtual second-level table allocated in the second-level caches. Virtualization is applied to a state-of-the-art multi-table branch predictor. We evaluate the design using instruction count as proxy for timing on a set of commercial workloads. For a predictor whose size is determined by access delay constraints, accuracy can be improved by 8.7%. Alternatively, the design can be used to achieve the same accuracy as a non-virtualized design while using 25% less dedicated storage.
An approach to the design of highly reliable and fail-safe digital systems

Recent progress in electronic technology has resulted in extensive use of electronic digital or logical systems in many complex control processes where weight or size as well as reliability and safety is important. Typical examples are, to name a few, nuclear reactor control, missile guidance systems, "fly-by-wire" systems in aircraft or spaceship control, and electronic telephone switching systems (ESS). In such applications, if the system is not well protected, some failure could result in a catastrophic accident or unacceptable loss in terms of lives and resources. For the system to be safe and reliable, not only the computers or digital systems in the control loop have to be reliable, but also the sub-systems which take part in the data acquisition or control should be fail-safe and reliable. In order to lessen the chance of system breakdown and unsafe failures in applications of this nature, many protective methods have been proposed and studied. Generally, the methods can be classified as: (1) fault-masking approach, where the emphasis is on achieving higher reliability by using redundancy to mask failures, and (2) fail-safe approach where attention is directed to the design of systems in such a way that they take a predetermined safe state whenever failures occur.
Utilisation of rheumatology care services in Germany: the case of physical therapy and self-help groups

Physical Therapy (PT) and self-help groups (SHG) are important components of health care in rheumatic diseases. The utilisation of PT and SHG by patients with rheumatic diseases may be influenced by several factors. The aim of this study is to summarize the evidence on PT and SHG utilisation of patients with rheumatic diseases in Germany. We systematically searched the MEDLINE-database for studies that evaluated the utilisation and factors that possibly influence the utilisation of PT and SHG. Eight studies were found for PT-utilisation and one for SHG-utilisation. Between 25 and 59 percent of patients with rheumatic diseases received PT services. Several individual and contextual factors that may influence the utilisation could be identified. In conclusion, evidence exists for wide variations in the utilisation of PT services and an underuse of such services among patients with rheumatic diseases in Germany. By contrast, little evidence exists on the utilisation of SHG.