Miracle-dz/UniFAR-FTUs huggingface dataset:
Reducing Racism: A Reply to Blanchard, Lilly, and Vaughn

In "Forward to the electronic archive," Gardner (1990) states, "Stodolsky suggests that the cost of producing and distributing electronic documents will be negligible, and while I hope he is right, like Hunt I doubt it. " In my contribution earlier in that issue, "Archiving secure interactions" (Stodolsky, 1990), I stated, however, "The average cost per reader [for Comp.groupware] was estimated at two cents per month. (This figure includes only direct communications costs.)" (emphasis added). Thus, my figure included only distribution costs. Actually, only incremental distribution costs of communicating information over a preexisting network. While the term "producing" as used by Gardner (1990) could be limited to the costs of equipment needed to prepare a message, in the context of this discussion"Publishers . will need to obtain a 'return for their efforts. (Gardner, 1990)"-there is clearly a different meaning being applied than the one used in my argument. I argued specifically against the employment of intermediaries, of any sort, in communication among scientists. Similarly, the figure I gave does not include the user's capital investment in equipment for communication. However, given that almost all scientific documents are already being produced on computers, the capital investment for document production, in the narrow sense, is already made. The fact that many of these machines are already connected to networks also eliminates the capital investment related to communication. Thus, I would argue that the incremental costs of communicating information over preexisting networks is the most realistic one to consider in the context of an electronic archive. This will certainly be even more true in the future, when every computer comes equipped with communication software and hardware. The cost of disseminating Comp.groupware was presented recently as $0.00 per person per month. That is, within the technical framework of Usenet, the cost of transmitting this conference had become negligible. This was for a conference reaching an estimated 17,000 people, with 47 messages for a total of 119 kilobytes of traffic in the month of July 1990 (Reid, 1990a). October 1990 cost was the same with 19,000 estimated readers and 26 messages for a total of 114 kilobytes of traffic (Reid, 1990b). This same cost figure was given for 287 of 672 conferences reported in October 1990 (Reid, 1990b). These costs are calculated assuming the use of longdistance dial-up telephone connections. This probably overestimates the actual (incremental) costs of transmitting the information. Actually, I find these considerations, either of communication costs or of the costs of nonscientific man power, to be beside the real point of the new technological capabilities. Nowhere in this special section was there serious consideration of the psychological implications of the new capabilities that allow communications between scientists unimpeded by "gatekeepers" or other intermediaries.
The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation

RNA-binding proteins (RBPs) facilitate post-transcriptional control of eukaryotic gene expression at multiple levels. The RBP tristetraprolin (TTP/Zfp36) is a signal-induced phosphorylated anti-inflammatory protein guiding unstable mRNAs of pro-inflammatory proteins for degradation and preventing translation. Using iCLIP, we have identified numerous mRNA targets bound by wild-type TTP and by a non-MK2-phosphorylatable TTP mutant (TTP-AA) in 1 h LPS-stimulated macrophages and correlated their interaction with TTP to changes at the level of mRNA abundance and translation in a transcriptome-wide manner. The close similarity of the transcriptomes of TTP-deficient and TTP-expressing macrophages upon short LPS stimulation suggested an effective inactivation of TTP by MK2, whereas retained RNA-binding capacity of TTP-AA to 3′UTRs caused profound changes in the transcriptome and translatome, altered NF-κB-activation and induced cell death. Increased TTP binding to the 3′UTR of feedback inhibitor mRNAs, such as Ier3, Dusp1 or Tnfaip3, in the absence of MK2-dependent TTP neutralization resulted in a strong reduction of their protein synthesis contributing to the deregulation of the NF-κB-signaling pathway. Taken together, our study uncovers a role of TTP as a suppressor of feedback inhibitors of inflammation and highlights the importance of fine-tuned TTP activity-regulation by MK2 in order to control the pro-inflammatory response.
High Performance Speed Sensorless Control of Three-Phase Induction Motor Based on Cloud Computing

Induction motor is a cast of alternating current motor where charge endures allotted to the rotor close-at-hand deputation of conductive charge. These motors are broadly applied in industrial claim due to they are arduous along with adhere no contacts. The speed controller of deltoid phase induction motor is applied to alleviate the aberration of speed. The central constructivist of this paper is to accrue the performance of speed sensorless control of three phase induction motor. To increase its performance, this paper presents a modified method for speed controller of an indirect vector- controlled induction motor drive using cloud computing technique. Our methodology depends on speed sensorless scheme to obtain the speed signal feedback; the speed estimator is based on model reference adaptive control that uses the stator current and rotor flux as state variables for estimating the speed. In this method, the stator current error is represented as a function of first degree of the estimated speed error. An analysis and simulation of the tried algorithm is birthed and applied easing a TMS320C31 floating-point notational alert Processor. And accumulate the action of the three phase induction motor we conceived our appraisals affixed to the accountant based on cloud computing tactics. This intelligent policy uses the guidelines of the speed controller efficiently. Simulation and experimental results depicted that the motor speed is decelerated articulately to destine its illusion apprise without above and inferior smack and with about zero steady state error. The apprised accelerate alert and its dispatching buoy amassed off line from burlesque. After effects display an advantageous affinity among the accounted speed alert and it's dispatching allocated as well as aped speed flares.
Performance Comparison of Novel, Robust Spatial Domain Digital Image Watermarking with the Conventional Frequency Domain Watermarking Techniques

Data authentication is one of the primary requisites in present day communication systems. In image processing, data authentication is implemented by using watermarking techniques. Nevertheless, whatever be the technique of watermarking, one of the important factors to be considered is robustness. In this paper we discuss about a novel robust method for digital watermarking in spatial domain. The method deals with an image in the spatial domain which is watermarked at different intensity subsections. Further, weave analyzed the performance of the proposed method by implementing the method using Verilog HDL & Matlab. A comparison of the proposed novel spatial domain method with the frequency domain method is also given here. We have implemented a frequency domain DCT/IDCT based digital watermarking as in [1] and [2]. We also compare the PSNR that can be obtained using the proposed spatial domain watermarking and the DCT/IDCT based watermarking.
Analysis of the integration of human papillomaviruses in head and neck tumours in relation to patients' prognosis

Integration, which leads to the disruption of the circular HPV genome, is considered as a critical, albeit not obligatory, step in carcinogenic progression. Although cervical carcinomas with extrachromosomal HPV plasmid genomes have been described, the virus is integrated in 70% of HPV16‐positive cervical tumours. Limited information is available about HPV integration in head and neck tumours (HNC). In this study, we have characterised the physical status of HPV in a set of tonsillar tumour samples using different methods—the mapping of E2 integration breakpoint at the mRNA level, the 3’ RACE based Amplification of Papillomavirus Oncogene Transcripts (APOT) assay and Southern blot. Furthermore, the impact of HPV integration on patients' prognosis has been evaluated in a larger set of 186 patients with head and neck cancer. Based on the analysis of E2 mRNA, HPV was integrated in the host genome in 43% of the HPV‐positive samples. Extrachromosomal or mixed form was present in 57%. In fresh frozen samples, the APOT and E2 mapping results were in agreement. The results were confirmed using Southern blotting. Furthermore, the type and exact site of integration were determined. The survival analysis of 186 patients revealed HPV positivity, tumour size and lymph node positivity as factors that influence disease specific survival. However, no statistically significant difference was found in disease specific survival between patients with HPV‐positive integrated vs. extrachromosomal/mixed forms of the virus.
PC_FFIW A Robust Image Matching Algorithm

matching, it's a crucial problem in computer vision and image processing. In order to improve the matching results, a proposed solution consists on employing geometric constraints. In this paper, we propose two effectiveness matching methods, which are called "First Found Is Winner" (FFIW) and "Polarity Coordinates And FFIW" (PC_FFIW). The first one is based on photometric data, while the second one, uses both photometric and geometric data. The proposed methods are based on three-step. Firstly, we detect for each image its corner points. Secondly, descriptors vectors are calculated for each corner points. Thirdly, to match the pair of images and , we apply a matching algorithm optimized to find the best match for each descriptor from the first image with the descriptors of the second image. Experimental results presented to demonstrate that our proposed methods are efficient and give promising results in terms of repeatability and processing time.
The Comparison of Mydriatic Effect Between Two Drugs of Different Mechanism

Purpose To maximize effective use of mydriatic drugs through comparing the pupillary dilation effects between 1% tropicamide and 2.5% phenylephrine. Methods Fifty people requiring pupillary dilation were divided into 3 groups. Group 1 was treated with one drop of 1% tropicamide in the right eye and one drop of 2.5% phenylephrine in the left eye. Group 2 was treated twice during a 5-minute interval with 1% tropicamide in the right eye. Group 3 was treated twice during a 5-minute interval with 2.5% phenylephrine in the right eye. Groups 2 and 3 were treated with 2.5% phenylephrine and 1% tropicamide in the left eye, administered during a 5-minute interval. The pupillary size was measured in all groups for 40 minutes following eye drops administration. Results The mean patient age was 15.7 years. Group 1 included 10 patients, and groups 2 and 3 included 20 patients each. Eight patients in group 1 and 16 patients in group 2 developed a larger right pupil. Fourteen patients in group 3 developed a larger left pupil. Conclusions Our study showed that 1% tropicamide, with its parasympathetic antagonistic mechanism of action, was more effective at inducing pupillary dilation than 2.5% phenylephrine, and the combination of 1% tropicamide and 2.5% phenylephrine was more effective than multiple drops of single eye drops.
Margaret Atwood: The Surfacing of Women's Spiritual Quest and Vision

Margaret Atwood's Surfacing is about a woman's spiritual quest; the unnamed protagonist of her novel seeks redemption.1 The powerful religious vision of Surfacing merits the attention of feminist critics both in religion and in literature. To do justice to this novel and others like it, feminist critics must move into an area at the junction of religion and literature and develop an understanding of the spiritual quest novel. Because certain features of Atwood's protagonist's quest and vision derive from her experience as a twentieth-century woman, and because women's religious experience is little understood, I have chosen to focus my interpretation on those aspects of the novel which reflect a particularly female spiritual quest and vision. To guard against misunderstanding, let me state that when I refer to women's, or female, experience, quest, or vision, I do not mean to refer to an "eternal feminine" principle, nor to exclude men. I simply refer to a viewpoint rooted in and reflective of women's experiences in a particular time and place. The interpretation of Surfacing as a spiritual quest leads to distin-
A Cross-Sectional Comparison of Different Resistance Training Techniques in the Bench Press

Seven alternative resistance training techniques, performed using a bench press exercise, were compared with heavy weight training (HWT) on a number of variables. These resistance training techniques included isokinetics, eccentrics, functional isometrics, super slow motion, rest pause, breakdowns, and maximal power training. The main results were that eccentrics and isokinetics had significantly (p , 0.05) greater levels of force and integrated electromyography than HWT during the eccentric phase. Likewise, functional isometrics had significantly more force and breakdowns significantly higher triceps brachii electromyography than HWT in the concentric phase. Super slow motion and maximal power training both recorded significantly lower levels of force and integrated electromyography than HWT in each phase. However, super slow motion resulted in significantly greater time under tension (61.70 6 2.12 vs. 21.15 6 0.92 seconds) than HWT. Maximal power training recorded significantly greater levels of power production than HWT in both the eccentric and concentric phases. Although no alternative resistance training techniques were found to produce significantly greater levels of blood lactate response than HWT, maximal power training and eccentrics produced significantly lower levels.
(Anti–)de Sitter black holes in higher derivative gravity and dual conformal field theories

The thermodynamics of five-dimensional Schwarzschild anti\char21{}de Sitter (SAdS) and SdS black holes (BHs) in the particular model of higher derivative gravity is considered. The free energy, mass (thermodynamical energy) and entropy are evaluated. A parameter region exists where BH entropy is zero or negative. Arguments are given that the corresponding BH solutions are not stable. We also present the Friedmann-Robertson-Walker (FRW) equations of motion of time- (space-)like branes in SAdS or SdS BH backgrounds. The properties of dual conformal field theory (CFT) are discussed and it is shown that it has a zero Casimir energy when BH entropy (effective gravitational constant) is zero. The Cardy-Verlinde formula for CFT dual to a SAdS or SdS BH is found in a universal form.
QU-BIGIR at SemEval 2017 Task 3: Using Similarity Features for Arabic Community Question Answering Forums

In this paper we describe our QU-BIGIR system for the Arabic subtask D of the SemEval 2017 Task 3. Our approach builds on our participation in the past version of the same subtask. This year, our system uses different similarity measures that encodes lexical and semantic pairwise similarity of text pairs. In addition to well known similarity measures such as cosine similarity, we use other measures based on the summary statistics of word embedding representation for a given text. To rank a list of candidate question answer pairs for a given question, we learn a linear SVM classifier over our similarity features. Our best resulting run came second in subtask D with a very competitive performance to the first-ranking system.
Primary Role for GI Protein Signaling in the Regulation of Interleukin 12 Production and the Induction of T Helper Cell Type 1 Responses

We explored the role of Gi protein signaling in the regulation of interleukin (IL)-12 production and T helper cell type 1 (Th1) T cell differentiation. In initial studies, we showed that treatment of normal mice with pertussis toxin (PT), which inhibits Gi protein signaling, enhanced the capacity of splenocytes to produce IL-12 in response to both microbial and nonmicrobial stimuli. In addition, PT treatment increased the production of tumor necrosis factor (TNF)-α and IL-10 by stimulated cells. These findings were corroborated by the fact that untreated Gi2α2/− mice exhibited enhanced production of IL-12 and TNF-α by splenocytes, and of IL-12 p40 by purified spleen CD8α+ lymphoid dendritic cells. Finally, we showed that while normal BALB/c mice infected with Leishmania major exhibited a nonhealing phenotype, those treated with PT when infection was initiated exhibited a healing phenotype along with an enhancement of leishmania-specific Th1 responses in draining lymph nodes. Further, healing was prevented by coadministration of anti–IL-12 and PT. These data demonstrate that endogenous Gi protein signaling has a primary role in the regulation of IL-12 production and the induction of Th1 responses in vivo.
Analysis of Eosinophil Turnover In Vivo Reveals Their Active Recruitment to and Prolonged Survival in the Peritoneal Cavity1

Eosinophils are potent effector cells associated with allergic inflammation and parasite infections. However, limited information exists about their turnover, migration, and survival in vivo. To address these important questions, we determined murine eosinophil turnover under steady state and inflammatory conditions by flow cytometric analysis of BrdU incorporation and analyzed their migration pattern and survival in different tissues after adoptive transfer into recipient mice. In naive mice ∼50% of bone marrow eosinophils were labeled with BrdU during a 15-h pulse, whereas only 10% of splenic eosinophils were labeled within this time frame. Unexpectedly, the rate of eosinophil production did not change during acute infection with the helminth parasite Nippostrongylus brasiliensis despite massive eosinophilia in several tissues. Eosinophils present in lung and peritoneum remained largely BrdU negative, indicating that eosinophilia in end organs was mainly caused by increased survival of already existing eosinophils rather than increased production of new eosinophils in the bone marrow. Adoptive transfer experiments revealed that eosinophils preferentially migrated to the peritoneum in a macrophage-independent and pertussis toxin-sensitive manner, where they survived for several days. Peritoneal eosinophils expressed high levels of the inhibitory receptor Siglec-F, released less eosinophil peroxidase compared with eosinophils from the spleen, and could recirculate to other organs. These results demonstrate that the peritoneum serves as reservoir for eosinophils.
Safety, Tolerability, and Pharmacokinetics of an Extended-Release Formulation of Fluvastatin Administered Once Daily to Patients with Primary Hypercholesterolemia

Fluvastatin sodium (Lescol®, Novartis Pharmaceutical Corp., East Hanover, NJ, U.S.A.), a potent 3-hydroxy-3-methylglutaryl coenzyme A (HMG Co-A) reductase inhibitor that limits cholesterol biosynthesis, is available as a 40-mg immediate-release formulation capsule. An extended-release formulation for once-daily administration has been developed for patients with primary hypercholesterolemia who may benefit from doses higher than 40 mg/day. This phase I study evaluated the safety, tolerability, and pharmacokinetics of a new fluvastatin extended-release formulation at doses ranging from 80–640 mg/day in 40 hypercholesterolemic patients. After a 2-week dietary stabilization phase, patients (Fredrickson type IIa/IIb), 18–55 years of age, were randomly assigned to four groups to receive oral fluvastatin extended-release (80, 160, 320, or 640 mg) or matching placebo once daily for 13 days. Fluvastatin extended-release was generally safe and well tolerated at doses of 80–320 mg/day. Within this dose range, linear pharmacokinetics was observed after single and multiple dosing. At 640 mg, fluvastatin extended-release was not well tolerated. Six of the seven actively treated patients at this dose experienced adverse events, including diarrhea, headache, and clinically relevant elevations in serum transaminase concentrations. In addition, nonlinear pharmacokinetics, possibly due to saturation of first-pass metabolism, was observed at this dose, causing higher than expected serum drug concentrations. Once-daily administration of fluvastatin extended-release at doses of 80–320 mg/day was generally safe and well tolerated in patients with primary hypercholesterolemia over a 13-day dosing period.
Efficient solving of structural constraints

Structural constraint solving is being increasingly used for software reliability tasks such as systematic testing or error recovery. For example, the Korat algorithm provides constraint-based test generation: given a Java predicate that describes desired input constraints and a bound on the input size, Korat systematically searches the bounded input space of the predicate to generate all inputs that satisfy the constraints. As another example, the STARC tool uses a constraint-based search to repair broken data structures. A key issue for these approaches is the efficiency of search. This paper presents a novel approach that significantly improves the efficiency of structural constraint solvers. Specifically, most existing approaches use backtracking through code re-execution to explore their search space. In contrast, our approach performs checkpoint-based backtracking by storing partial program states and performing abstract undo operations. The heart of our approach is a light-weight search that is performed purely through code instrumentation. The experimental results on Korat and STARC for generating and repairing a set of complex data structures show an order to two orders of magnitude speed-up over the traditionally used searches.
The geometric framework for nutrition reveals interactions between protein and carbohydrate during larval growth in honey bees

ABSTRACT In holometabolous insects, larval nutrition affects adult body size, a life history trait with a profound influence on performance and fitness. Individual nutritional components of larval diets are often complex and may interact with one another, necessitating the use of a geometric framework for elucidating nutritional effects. In the honey bee, Apis mellifera, nurse bees provision food to developing larvae, directly moderating growth rates and caste development. However, the eusocial nature of honey bees makes nutritional studies challenging, because diet components cannot be systematically manipulated in the hive. Using in vitro rearing, we investigated the roles and interactions between carbohydrate and protein content on larval survival, growth, and development in A. mellifera. We applied a geometric framework to determine how these two nutritional components interact across nine artificial diets. Honey bees successfully completed larval development under a wide range of protein and carbohydrate contents, with the medium protein (∼5%) diet having the highest survival. Protein and carbohydrate both had significant and non-linear effects on growth rate, with the highest growth rates observed on a medium-protein, low-carbohydrate diet. Diet composition did not have a statistically significant effect on development time. These results confirm previous findings that protein and carbohydrate content affect the growth of A. mellifera larvae. However, this study identified an interaction between carbohydrate and protein content that indicates a low-protein, high-carb diet has a negative effect on larval growth and survival. These results imply that worker recruitment in the hive would decline under low protein conditions, even when nectar abundance or honey stores are sufficient. Summary: Protein to carbohydrate ratio affects the survival and growth rate of larval worker honey bees in vitro. Protein and carbohydrate content of food interact in complex ways to alter growth rate, development time and survival in worker bound honey bee larvae.