Miracle-dz/UniFAR-FTUs huggingface dataset:
Exercise motivation, eating, and body image variables as predictors of weight control.

PURPOSE This study investigated changes in psychosocial variables related to exercise, eating, and body image during a weight reduction program and evaluated their association with weight loss in middle-aged overweight and obese women up to 1 yr after intervention. METHODS The 136 participants (age, 48.1 +/- 4.4 yr; weight, 30.6 +/- 5.6 kg x m(-2)) who completed the 4-month lifestyle weight reduction program (86% retention), losing -6.2 +/- 4.6% (P < 0.001) of their initial weight, were followed up for 12 additional months. Of these, 82% completed 16-month assessments (weight change, -5.5 +/- 7.7%, P < 0.001). Psychosocial variables were assessed by validated instruments in standardized conditions at baseline and after the intervention (4 months). RESULTS Compared with 4-month assessments, body weight did not change at 16 months (P > 0.09). Changes in eating restraint, disinhibition, and hunger; exercise, self-efficacy, and intrinsic motivation; body shape concerns; and physical self-worth were associated with weight change at 4 months (P < 0.001, except hunger, P < 0.05). Baseline-adjusted 4-month scores in all psychosocial variables also predicted weight change from baseline to 16 months (P < 0.01), except hunger (P > 0.05). After controlling for 4-month weight change and other covariates, increases in exercise intrinsic motivation remained predictive of weight loss at 16 months (P < 0.05). Multiple linear regression showed that eating variables were significant and independent correlates of short-term weight change, whereas changes in exercise variables were stronger predictors of longer term weight outcomes. CONCLUSIONS Results highlight the importance of cognitive processes during weight control and support the notion that initial focus on diet is associated with short-term weight loss, while change in exercise-related motivational factors, with a special emphasis on intrinsic sources of motivation (e.g., interest and enjoyment in exercise), play a more important role in longer term weight management.
NUCLEAR‐CYTOPLASMIC INTERACTIONS REDUCE MALE FERTILITY IN HYBRIDS OF ARABIDOPSIS LYRATA SUBSPECIES

We examined the level of postzygotic reproductive isolation in F1 and F2 hybrids of reciprocal crosses between the Arabidopsis lyrata subspecies lyrata (North American) and petraea (European). Our main results are: first, the percentage of fertile pollen was significantly reduced in the F1 and F2 compared to the parental populations. Second, mean pollen fertility differed markedly between reciprocal crosses: 84% in the F2 with ssp. lyrata cytoplasm and 61% in the F2 with ssp. petraea cytoplasm. Third, 17% of the F2 with ssp. petraea cytoplasm showed male sterility (produced less than 30 pollen grains in our subsample). The hybrids were female fertile. We used QTL mapping to find the genomic regions that determine pollen fertility and that restore cytoplasmic male sterility (CMS). In the F2 with ssp. lyrata cytoplasm, an epistatic pair of QTLs was detected. In the reciprocal F2 progeny, four QTLs demonstrated within‐population polymorphism for hybrid male sterility. In addition, in the F2 with ssp. petraea cytoplasm, there was a strong male fertility restorer locus on chromosome 2 where a cluster of CMS restorer gene‐related PPR genes have been found in A. lyrata. Our results underline the importance of cytonuclear interactions in understanding genetics of the early stages of speciation.
Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations.

We have recently demonstrated that inherited defects of the base excision repair gene MYH predispose to multiple colorectal adenomas and carcinoma. Three affected siblings from a single British family were identified as Y165C/G382D compound heterozygotes and both missense mutations were shown to be functionally compromised. Here, we report the identification of seven further unrelated patients with >100 colorectal adenomas (six with colorectal cancer) and biallelic germline mutations in MYH: four were homozygous for truncating mutations, two were homozygous for Y165C and one was a Y165C/G382D compound heterozygote. As predicted from studies of the bacterial and yeast orthologues of MYH, colorectal tumours from affected individuals displayed a significant excess of somatic G:C-->T:A mutations in APC, as compared to sporadic ( chi(2)=242.96, P<10(-20)) or FAP-associated ( chi(2)=194.85, P<10(-20)) colorectal tumours. The sequence immediately downstream of the somatic G:C-->T:A mutations was predominantly AA, irrespective of the nature of the germline MYH mutations. These findings confirm the role of MYH in colorectal adenoma and carcinoma predisposition.
A monotonic digitally controlled delay element

A monotonic digitally controlled delay element (DCDE) is implemented in the 0.18 /spl mu/m CMOS technology. In this paper, the design procedure of the new architecture and measurement results are reported. The delay of the DCDE changes monotonically with respect to the digital input vector. The monotonicity is one of the important features of this new architecture. Due to its monotonic behavior, the design of the DCDE is rather straightforward. The DCDE can be analyzed by a simple set of empirical equations with reasonable accuracy and can be made more tolerant to process, temperature, and supply voltage variations. The implemented delay element provides a delay resolution of as low as 2 ps and consumes 170 /spl mu/W to 340 /spl mu/W static power depending on the digital input vector.
Urinary incontinence and related urogenital symptoms in elderly women

The aims of this study were to investigate the prevalence of urinary incontinence (UI), urinary tract infections (UTI) and related urogenital symptoms (UGS) in a representative sample of elderly women (Papers I & II), and to investigate factors (Papers II & III) influencing the prevalence of UI in these women. The effects of treatment with oral estriol and placebo on the vaginal bacterial flora, vaginal cytology and urogenital symptoms in elderly women suffering from the urogenital estrogen deficiency syndrome were compared (Paper IV). A health care programme, based on an algorithm model, for the investigation and treatment of elderly women suffering from UI and related UGS, was designed and applied to a large group of elderly women (Paper V).
BOLD Responses Reflecting Dopaminergic Signals in the Human Ventral Tegmental Area

Current theories hypothesize that dopamine neuronal firing encodes reward prediction errors. Although studies in nonhuman species provide direct support for this theory, functional magnetic resonance imaging (fMRI) studies in humans have focused on brain areas targeted by dopamine neurons [ventral striatum (VStr)] rather than on brainstem dopaminergic nuclei [ventral tegmental area (VTA) and substantia nigra]. We used fMRI tailored to directly image the brainstem. When primary rewards were used in an experiment, the VTA blood oxygen level–dependent (BOLD) response reflected a positive reward prediction error, whereas the VStr encoded positive and negative reward prediction errors. When monetary gains and losses were used, VTA BOLD responses reflected positive reward prediction errors modulated by the probability of winning. We detected no significant VTA BOLD response to nonrewarding events.
Natively unfolded proteins: A point where biology waits for physics

The experimental material accumulated in the literature on the conformational behavior of intrinsically unstructured (natively unfolded) proteins was analyzed. Results of this analysis showed that these proteins do not possess uniform structural properties, as expected for members of a single thermodynamic entity. Rather, these proteins may be divided into two structurally different groups: intrinsic coils, and premolten globules. Proteins from the first group have hydrodynamic dimensions typical of random coils in poor solvent and do not possess any (or almost any) ordered secondary structure. Proteins from the second group are essentially more compact, exhibiting some amount of residual secondary structure, although they are still less dense than native or molten globule proteins. An important feature of the intrinsically unstructured proteins is that they undergo disorder–order transition during or prior to their biological function. In this respect, the Protein Quartet model, with function arising from four specific conformations (ordered forms, molten globules, premolten globules, and random coils) and transitions between any two of the states, is discussed.
Sensorless IPMSM drive with rotor position estimator based on analysis of phase current derivatives

This paper describes a sensorless Interior Permanent Magnet Synchronous Motor (IPMSM) drive designed for traction applications. Wide-speed sensorless operation is provided with the use of three methods of rotor position estimation designed for: a standstill, low- and high-speed range. The paper focuses on the high-speed estimation algorithm. The estimator uses the derivatives of motor phase currents resulting from PWM modulation to obtain the rotor position. The algorithm is characterized by very simple formulae. The calculation of the rotor position is performed in every PWM cycle. However, the determination of phase current derivatives requires a special current measurement algorithm in which sampling is coordinated with inverter transistors switching. The basis of the algorithm is presented, accompanied by an error analysis. The current sampling issues are reviewed and the laboratory test results are given and discussed.
Survey of adolescents’ stress in school life in Thailand: Implications for school health

Stress among adolescents is a widely discussed topic. This study examined stress levels, stress-related factors, and the possible correlation between stress and depression in adolescents at high schools in Thailand. The survey measuring stress (T-PSS-10) and depression (PHQ-9) was conducted on 15- to 19-year-olds in three public urban schools (n = 168, response rate 90%). The data were analysed with descriptive statistics followed by the analysis of the background factors and their associations with adolescent stress levels using χ 2 tests, or Pearson’s correlation coefficient, while the mean differences between groups were tested with a T-test or analysis of variance. Adolescent stress levels ranged from 6 to 34 points, 17 being the most typical score (mean 15.95, SD 4.95, n = 164); the higher the score, the more the respondents perceived their lives to be stressful. There were no significant differences in stress levels among adolescents relating to age, gender, regular school attendance or which school attended. However, adolescents’ high stress levels were associated with having a high number of depressive symptoms (r = 0.69, p = < 0.001). Effective mechanisms and more studies need to be carried out in the school environment to monitor, identify and support adolescents’ health and well-being.
Bis(O-n-butyl dithiocarbonato-κ2 S,S′)bis(pyridine-κN)manganese(II)

The structure of the title manganese complex, [Mn(C5H9OS2)2(C5H5N)2] or [Mn(S2CO-n-Bu)2(C5H5N)2], consists of discrete monomeric entities with Mn2+ ions located on centres of inversion. The metal atom is coordinated by a six-coordinate trans-N2S4 donor set with the pyridyl N atoms located in the apical positions. The observed slight deviations from octahedral geometry are caused by the bite angle of the bidentate κ2-S2CO-n-Bu ligands [69.48 (1)°]. The O(CH2)3(CH3) chains of the O-n-butyl dithiocarbonate units are disordered over two sets of sites with an occupancy ratio of 0.589 (2):0.411 (2).
Crop yield responses to prices: a Bayesian approach to blend experimental and market data

We estimate yield-price elasticities by blending information from market-based datasets with experimental production data using a Bayesian procedure. Yield-price elasticities are dictated by features of the underlying production technology; therefore, data on crop response to relevant inputs provide extra information about parameters of interest. Bayesian econometrics allows for the joint and simultaneous estimation of all model parameters. The procedure is advocated in situations where field trail or experimental data are available to provide additional information helping recovering production technology parameters with higher precision.
Binding of Avian Coronavirus Spike Proteins to Host Factors Reflects Virus Tropism and Pathogenicity

ABSTRACT The binding of viruses to host cells is the first step in determining tropism and pathogenicity. While avian infectious bronchitis coronavirus (IBV) infection and avian influenza A virus (IAV) infection both depend on α2,3-linked sialic acids, the host tropism of IBV is restricted compared to that of IAV. Here we investigated whether the interaction between the viral attachment proteins and the host could explain these differences by using recombinant spike domains (S1) of IBV strains with different pathogenicities, as well as the hemagglutinin (HA) protein of IAV H5N1. Protein histochemistry showed that S1 of IBV strain M41 and HA of IAV subtype H5N1 displayed sialic acid-dependent binding to chicken respiratory tract tissue. However, while HA bound with high avidity to a broad range of α2,3-linked sialylated glycans, M41 S1 recognized only one particular α2,3-linked disialoside in a glycan array. When comparing the binding of recombinant IBV S1 proteins derived from IBV strains with known differences in tissue tropism and pathogenicity, we observed that while M41 S1 displayed binding to cilia and goblet cells of the chicken respiratory tract, S1 derived from the vaccine strain H120 or the nonvirulent Beaudette strain had reduced or no binding to chicken tissues, respectively, in agreement with the reduced abilities of these viruses to replicate in vivo. While the S1 protein derived from the nephropathogenic IBV strain B1648 also hardly displayed binding to respiratory tract cells, distinct binding to kidney cells was observed, but only after the removal of sialic acid from S1. In conclusion, our data demonstrate that the attachment patterns of the IBV S proteins correlate with the tropisms and pathogenicities of the corresponding viruses.
FR258900, a potential anti‐hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase

FR258900 has been discovered as a novel inhibitor of human liver glycogen phosphorylase a and proved to suppress hepatic glycogen breakdown and reduce plasma glucose concentrations in diabetic mice models. To elucidate the mechanism of inhibition, we have determined the crystal structure of the cocrystallized rabbit muscle glycogen phosphorylase b–FR258900 complex and refined it to 2.2 Å resolution. The structure demonstrates that the inhibitor binds at the allosteric activator site, where the physiological activator AMP binds. The contacts from FR258900 to glycogen phosphorylase are dominated by nonpolar van der Waals interactions with Gln71, Gln72, Phe196, and Val45′ (from the symmetry‐related subunit), and also by ionic interactions from the carboxylate groups to the three arginine residues (Arg242, Arg309, and Arg310) that form the allosteric phosphate‐recognition subsite. The binding of FR258900 to the protein promotes conformational changes that stabilize an inactive T‐state quaternary conformation of the enzyme. The ligand‐binding mode is different from those of the potent phenoxy‐phthalate and acyl urea inhibitors, previously described, illustrating the broad specificity of the allosteric site.
Interferon Therapy in Hemodialysis Patients with Chronic Hepatitis C: Study of Tolerance, Efficacy and Post-Transplantation Course

Background: The potential benefit of pre-transplant treatment of chronic hepatitis C on long-term evolution after renal transplantation is not clear. Methods: Fifty successive renal transplant candidates had their sera positive for HCV RNA and a biopsy-proven chronic hepatitis. Out of these, 18 patients received a standard course of interferon-α2b (IFN; 3 MU three times weekly after hemodialysis sessions for 6 months). Results: IFN was discontinued in 2 patients (11%) due to persistent leukopenia. HCV RNA turned negative in 10 patients of the treatment group and in none of the control group. Two patients of the IFN group had a virological relapse post-transplantation. Post-transplant follow-up periods were 41.5 ± 15 and 50 ± 16 months for the treated and control groups respectively. Transaminases remained normal in all patients of the IFN group after transplantation. In contrast, biochemical evidence of acute and chronic hepatitis was observed in 5 (p = 0.03) and 13 (p = 0.002) patients, respectively, of the control group. Logistic regression analysis identified non-receiving IFN before transplantation as a risk factor for post-transplant hepatic dysfunction (odds ratio = 11.7, p = 0.003) and for chronic allograft nephropathy (odds ratio = 11.6, p = 0.02). Conclusions: IFN-treated patients had a significantly better post-transplant hepatic function and significantly lower rates of chronic allograft nephropathy.
Prostate cancer survivorship care guideline: American Society of Clinical Oncology Clinical Practice Guideline endorsement.

PURPOSE The guideline aims to optimize health and quality of life for the post-treatment prostate cancer survivor by comprehensively addressing components of follow-up care, including health promotion, prostate cancer surveillance, screening for new cancers, long-term and late functional effects of the disease and its treatment, psychosocial issues, and coordination of care between the survivor's primary care physician and prostate cancer specialist. METHODS The American Cancer Society (ACS) Prostate Cancer Survivorship Care Guidelines were reviewed for developmental rigor by methodologists. The American Society of Clinical Oncology (ASCO) Endorsement Panel reviewed the content and recommendations, offering modifications and/or qualifying statements when deemed necessary. RESULTS The ASCO Endorsement Panel determined that the recommendations from the 2014 ACS Prostate Cancer Survivorship Care Guidelines are clear, thorough, and relevant, despite the limited availability of high-quality evidence to support many of the recommendations. ASCO endorses the ACS Prostate Cancer Survivorship Care Guidelines, with a number of qualifying statements and modifications. RECOMMENDATIONS Assess information needs related to prostate cancer, prostate cancer treatment, adverse effects, and other health concerns and provide or refer survivors to appropriate resources. Measure prostate-specific antigen (PSA) level every 6 to 12 months for the first 5 years and then annually, considering more frequent evaluation in men at high risk for recurrence and in candidates for salvage therapy. Refer survivors with elevated or increasing PSA levels back to their primary treating physician for evaluation and management. Adhere to ACS guidelines for the early detection of cancer. Assess and manage physical and psychosocial effects of prostate cancer and its treatment. Annually assess for the presence of long-term or late effects of prostate cancer and its treatment.
Effect of hyperinsulinaemia–hyperaminoacidaemia on leg muscle protein synthesis and breakdown: reassessment of the two‐pool arterio‐venous balance model

Accurate measurements of muscle protein synthesis and breakdown rates are critical for understanding the processes underlying muscle atrophy and hypertrophy. Several mathematical approaches have been described to derive muscle protein synthesis and breakdown rates from a two‐pool (artery–vein) model including metabolic tracers. We found that only some of the published approaches provide accurate protein turnover rates and only when the computations are made with mole percent excess as the measure of tracer enrichment and the sum of tracer and tracee as the corresponding concentration in the artery and vein; errors, up to several‐fold in magnitude, result when computations are made with unlabelled concentration only, and/or enrichment expressed as tracer‐to‐tracee ratio or with any of the other equations (irrespective of how concentration and enrichment are expressed). Interpretation of muscle protein turnover rates and their validity requires careful attention to the mathematical approach used to calculate them.
Palonosetron for the treatment of chemotherapy-induced nausea and vomiting

Introduction: Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life. The emetogenicity of the chemotherapeutic agents, repeated chemotherapy cycles, and patient risk factors significantly influence CINV. The introduction of 5-hydroxytryptamine-3 (5-HT3) receptor antagonists has been a major factor in the improvement of the prevention of chemotherapy-induced acute and delayed emesis. Palonosetron, a second-generation 5-HT3 receptor antagonist with a different half-life, a different binding capacity, and a different mechanism of action than the first-generation 5-HT3 receptor antagonists appears to be the most effective agent in this drug class. Areas covered: Palonosetron’s chemistry, pharmacodynamics, pharmacokinetics, metabolism, clinical efficacy, including comparison with other antiemetics, role in controlling nausea, potential role in multi-day chemotherapy and bone marrow transplantation, and overall safety are discussed. Expert opinion: The clinical data in the literature have established palonosetron as the 5-HT3 receptor antagonist of choice in terms of efficacy and safety for the prevention of CINV for patients receiving moderately or highly emetogenic chemotherapy. Three international guidelines have listed palonosetron as the preferred 5-HT3 receptor antagonist. Due to its higher efficacy, the use of palonosetron may be more cost effective compared to the generic first-generation 5-HT3 receptor antagonists. Clinical organizations’ pharmacy and formulary committees should consider efficacy when making recommendations for agents for the prevention of CINV.
Employing Machine Translation in Glocalization Tasks – A Use Case Study

Today, we and our customers are faced with a huge amount of continuous data streams in multiple languages and different forms and formats. Therefore, our business communications requirements and strategies demand for an effective employment of various language resources to economically and efficiently administer, master and monitor information processes and workflows across languages, cultures and time zones. We have thoroughly investigated into what language resources are mostly suited for our needs, and what are the important enablers in different translingual technical deployment scenarios that guarantee throughput, scalability, quality and successful operations and applications. Although Machine Translation (MT) is still a gadget because neither individual nor business users do share the usability and quality of MT as a real user experience, MT is an intrinsic part of our solution. With this paper we want to share and discuss our findings on MT with the community.
Dynamic Multi-interface Services: An Application to the Design of a Multimedia Service

The development and widespread market acceptance of recent technological devices, such as smart phones and tablets, poses new challenges and great opportunities for innovative service designs. In fact these devices no longer merely replicate the same functionalities in different contexts, they can also dynamically interact among themselves when in close proximity. Thus, this is a two-fold challenge for service designers, they must handle the additional points of contact between service providers and their customers independently, and also in combinations. In this paper we present the relevant concepts for designing multi-interface services, and also introduce the concept of dynamic service interfaces. We illustrate these dynamic service interfaces by presenting an application to the design of a new multimedia service. This service makes use of dynamic service interfaces to deliver an improved and innovative customer experience.