Miracle-dz/UniFAR-FTUs huggingface dataset:
A Rare Case of Acute Myocardial Infarction due to Coronary Artery Dissection and Heparin-Induced Thrombocytopenia

Although both coronary artery dissection and heparin-induced thrombocytopenia may provoke myocardial infarction, it is extremely rare for both conditions to develop simultaneously in a single patient. We report a case of a 69-year-old woman who sustained a head-on motor vehicle accident with associated chest trauma. During a subsequent hospitalization, she was exposed to subcutaneous heparin and developed significant thrombocytopenia. Shortly thereafter, she re-presented with an acute myocardial infarction. Coronary angiography revealed a spiral dissection with superimposed thrombosis within the right coronary artery, while laboratory testing confirmed the diagnosis of heparin induced thrombocytopenia. She was treated with catheter-based thrombectomy and adjunctive direct thrombin inhibitor therapy, followed by three months of systemic anticoagulation with warfarin. To our knowledge, this represents the first published case of a native vessel myocardial infarction due to the combination of coronary artery dissection and heparin-induced thrombocytopenia.
Succeeding in empowering others: social factors that assist in creating and sustaining empowering organizational environments

This research rises out of the perceived gap between rhetoric and reality in the congregational life of the church in the United States. Using the research tools of autoethnography and case study, it investigates the life settings of the researcher and the interior organizational dynamics of three cases, a for-profit, a nonprofit and a church organization. The research considers how organizational pre-conditions and traits and processes, leadership behavior and perspectives and the perceived benefits of an empowering environment, impacts the ability of the organization to implement and sustain an empowering environment. Three pre-conditions, namely, a flexibility in organizational behaviours, the total commitment of the primary leader, and a particular view of people were found to be essential. Four relational traits of voice, trust, authentication, and connectivity were discovered to generate a relational environment that was conducive to an empowering culture. No particular leadership style was found to be essential, only that the style could embrace the elements enumerated above. Personal and organizational benefits were outside the normative expectations of profit or other numerical measurements and closer to aspects of relationally and energy. There appeasers to be no significant difference between church and other organizational types in how empowerment functions. I conclude by reflecting on practical aspects and how the research journey impacted the researcher.
Design of Arithmetic Circuits UsingResonant Tunneling Diodes and Threshold

This paper describes the design of arithmetic circuits based on hybrid integrated resonant tunneling diodes and heterostructure eld-eeect transistors. The key components are depth-2 parallel counters consisting of multiple terminal threshold gates. In particular, we propose a novel parallel addition scheme by combining threshold logic and systolic VLSI-algorithms for bit-level computations. The approach is motivated by the demand for locally interconnected circuit modules to solve the wiring problem in nanoelectronic circuits.
Accurate Formula for Quality Factor Q of Thin Film Bulk Acoustic Resonators with Close Series and Parallel Resonance Frequencies

This paper presents improved formula accuracy for quality factor Q of thin film bulk acoustic resonators (FBARs) with close series and parallel resonance frequencies. Traditionally, the series and parallel resonance behaviors are treated independently. The FBAR piezoelectric coupling coefficient is only a few percentages with the series and parallel frequencies close enough to influence each other. The FBARs with two-port configuration are fabricated using silicon bulk micro-machining technology. Including the FBAR transmission lines are analyzed to probe their characteristics using a network analyzer. The signal power loss of the transmission lines is modeled to characterize the FBARs using two-port S parameter measurement data.
Interaction of mitochondrial presequences with DnaK and mitochondrial hsp70.

Mitochondrial heat shock protein 70 (mt-hsp70) functions as a molecular chaperone in mitochondrial biogenesis. The chaperone in co-operation with its co-proteins acts as a translocation motor pulling the mitochondrial precursor into the matrix. Mt-hsp70s are highly conserved when compared to the bacterial hsp70 homologue, DnaK. Here we have used DnaK as a model to study the interaction of mitochondrial presequences with mt-hsp70 applying a DnaK-binding algorithm, computer modeling and biochemical investigations. DnaK-binding motifs have been analysed on all available, statistically relevant mitochondrial presequences found in the OWL database by running the algorithm. A total of 87 % of mammalian, 97 % of plant, 71 % of yeast and 100 % of Neurospora crassa presequences had at least one DnaK binding site. Based on the prediction, five 13-mer presequence peptides have been synthesized and their inhibitory effect on the molecular chaperone (DnaK/DnaJ/GrpE) assisted refolding of luciferase has been analysed. The peptide with the highest predicted binding likelihood showed the strongest inhibitory effect, whereas the peptide with no predicted binding capacity showed no inhibitory effect. A 3D structure of the pea mt-hsp70 has been constructed using homology modeling. The binding affinities of the 13-mer presequence peptides and additional control peptides to DnaK and pea mt-hsp70 have been theoretically estimated by calculating the buried hydrophobic surface area of the peptides docked to DnaK and to the mt-hsp70 structural model. These results suggest that mitochondrial presequences interact with the mt-hsp70 during or after mitochondrial protein import.
The impact of real estate on the terminal wealth of U.K. mixed-asset portfolios: 1972 - 2001

Executive Summary. This paper uses United Kingdom annual data for the period 1972-2001 to test whether including real estate in the mixed-asset portfolio not only reduces ex-post portfolio risk but also enhances portfolio terminal wealth (TW) and/or reduces the variability of TW. The conventional allocation problem can therefore be recast: Does real estate enhance the TW of the mixed-asset portfolio and/or reduce the variability of the TW? The results show that including real estate has a variety of impacts depending on the asset replaced and the percentage replaced. Replacing bonds leads to an increase in TW. Replacing equities considerably reduces TW. Replacement of both bonds and equities gives intermediate results, influenced chiefly by the performance of equities. Including real estate appears in most cases to offer an improvement in TW and a reduction in TWSD compared with the base portfolio (without real estate).
On Cross-lingual Plagiarism Analysis using a Statistical Model

The automatic detection of plagiarism is a task that has acquired relevance in the Information Retrieval area and it becomes more complex when the plagiarism is made in a multilingual panorama, where the original and suspicious texts are written in different languages. From a cross-lingual perspective, a text fragment in one language is considered a plagiarism of a text in another language if their contents are considered semantically similar no matter they are written in different languages and the corresponding citation or credit is not included. Our current experiments on cross-lingual plagiarism analysis are based on the exploitation of a statistical bilingual dictionary. This dictionary is created on the basis of a parallel corpus which contains original fragments written in one language and plagiarised versions of these fragments written in another language. The process for the automatic cross-lingual plagiarism analysis based on the statistical bilingual dictionary has shown good results and we consider that it could be useful also for the cross-lingual nearduplicate detection task.
An Approach to Identify a Model for Efficient Prediction of Exchange Rates Using Setty Volatile Index (SVI)

In recent years forecasting of financial data such as stock market, exchange rate, interest rate and bankruptcy has been observed to be a potential field of research due to its importance in financial and managerial decision making. Survey of existing literature reveals that there is a need to develop efficient forecasting models involving less computational load and fast forecasting capability. Our proposed work aims to fulfill this objective by analyzing and comparing different ANN and Fuzzy models with some specified attributes. These networks involve nonlinear inputs and simple ANN structure with few neurons. The models are functional link artificial neural network (FLANN) as well as Dynamic Radial Basis Functional Networks (RBF) model and hybrid NEURO-FUZZY model. These models have been tested to predict currency exchange rate between US dollar Indian Rupees and Japanese Yen and also stock market data like US-RUPEE and IBM etc. The performances of the proposed models have been evaluated through simulation and compared with those obtained from other models. Experimental results are compared on basis of various parameters including Normalized Root Mean Square Error (NRMSE), Mean Absolute Percentage Error (AMAPE), Volatility and Error Convergence. An approach is designed with the key parameter SVI (Setty Volatility Index) to classify the dataset and further decide the right model for the prediction problem.
Curvelets Based Queries for CBIR Application in Handwriting Collections

This paper presents a new use of the curvelet transform as a multiscale method for indexing linear singularities and curved handwritten shapes in documents images. As it belongs to the wavelet family, this representation can be useful at several scales of details. The proposed scheme for handwritten shape characterization targets to detect oriented and curved fragments at different scales so as to compose an unique signature for each handwritten analyzed samples. In this way, curvelets coefficients are used as a representation tool for handwriting when searching in large manuscripts databases by finding similar handwritten samples. Current results of ancient manuscripts retrieval are very promising with very satisfying precisions and recalls.
Use of Foreign Films in Cultivating Intercultural Communicative Competence in ELT—A Case Study

Foreign films have long been used in English Language Teaching (ELT) and been proved effective in improving learners’ linguistic competence. Cultivating Intercultural Communicative Competence (ICC) has gradually become a vital goal in English Language Teaching (ELT). However, whether foreign films can be used to improve learners’ ICC is less researched. Taking Byram’s ICC model, this paper tends to show foreign films can also be effective in improving learners’ ICC. This article reports an empirical study designed to explore the processes students engage in when viewing Disney film Mulan in a Chinese college classroom. Students’ study blogs, quizzes, and interviews are major research data and the analysis of the data illustrated foreign films’ role in cultivating learners’ ICC and explored the mental process of students’ interpretation of foreign films.
Multiple doublesex-Related Genes Specify Critical Cell Fates in a C. elegans Male Neural Circuit

Background In most animal species, males and females exhibit differences in behavior and morphology that relate to their respective roles in reproduction. DM (Doublesex/MAB-3) domain transcription factors are phylogenetically conserved regulators of sexual development. They are thought to establish sexual traits by sex-specifically modifying the activity of general developmental programs. However, there are few examples where the details of these interactions are known, particularly in the nervous system. Methodology/Principal Findings In this study, we show that two C. elegans DM domain genes, dmd-3 and mab-23, regulate sensory and muscle cell development in a male neural circuit required for mating. Using genetic approaches, we show that in the circuit sensory neurons, dmd-3 and mab-23 establish the correct pattern of dopaminergic (DA) and cholinergic (ACh) fate. We find that the ETS-domain transcription factor gene ast-1, a non-sex-specific, phylogenetically conserved activator of dopamine biosynthesis gene transcription, is broadly expressed in the circuit sensory neuron population. However, dmd-3 and mab-23 repress its activity in most cells, promoting ACh fate instead. A subset of neurons, preferentially exposed to a TGF-beta ligand, escape this repression because signal transduction pathway activity in these cells blocks dmd-3/mab-23 function, allowing DA fate to be established. Through optogenetic and pharmacological approaches, we show that the sensory and muscle cell characteristics controlled by dmd-3 and mab-23 are crucial for circuit function. Conclusions/Significance In the C. elegans male, DM domain genes dmd-3 and mab-23 regulate expression of cell sub-type characteristics that are critical for mating success. In particular, these factors limit the number of DA neurons in the male nervous system by sex-specifically regulating a phylogenetically conserved dopamine biosynthesis gene transcription factor. Homologous interactions between vertebrate counterparts could regulate sex differences in neuron sub-type populations in the brain.
Chip to wafer direct bonding technologies for high density 3D integration

We demonstrate chip to wafer assembly based on aligned Cu-Cu direct bonding. A collective die surface preparation for direct bonding has implemented to develop dies direct bonding, defect free. An accurate pick and place equipment was adapted to ensure a particle free environment. After a damascene-like surface preparation, chips were bonded with less than 1μm misalignment. 400°C bonded daisy chains on die to wafer structure are perfectly ohmic. Concurrently, to overcome speed limitation of pick and place technique, a self-assembly technique chip is developed. This technique is based on capillary effect for self alignment and direct bonding for assembly. A less than 1 μm alignment accuracy and a 90 per cent self assembly process yield are obtained.
Lexical Specification of Prosodic Information in Swedish: Evidence from Mismatch Negativity

Like that of many other Germanic languages, the stress system of Swedish has mainly undergone phonological analysis. Recently, however, researchers have begun to recognize the central role of morphology in these systems. Similar to the lexical specification of tonal accent, the Swedish stress system is claimed to be morphologically determined and morphemes are thus categorized as prosodically specified and prosodically unspecified. Prosodically specified morphemes bear stress information as part of their lexical representations and are classified as tonic (i.e., lexically stressed), pretonic and posttonic, whereas prosodically unspecified morphemes receive stress through a phonological rule that is right-edge oriented, but is sensitive to prosodic specification at that edge. The presence of prosodic specification is inferred from vowel quality and vowel quantity; if stress moves elsewhere, vowel quality and quantity change radically in phonologically stressed morphemes, whereas traces of stress remain in lexically stressed morphemes. The present study is the first to investigate whether stress is a lexical property of Swedish morphemes by comparing mismatch negativity (MMN) responses to vowel quality and quantity changes in phonologically stressed and lexically stressed words. In a passive oddball paradigm, 15 native speakers of Swedish were presented with standards and deviants, which differed from the standards in formant frequency and duration. Given that vowel quality and quantity changes are associated with morphological derivations only in phonologically stressed words, MMN responses are expected to be greater in phonologically stressed words than in lexically stressed words that lack such an association. The results indicated that the processing differences between phonologically and lexically stressed words were reflected in the amplitude and topography of MMN responses. Confirming the expectation, MMN amplitude was greater for the phonologically stressed word than for the lexically stressed word and showed a more widespread topographic distribution. The brain did not only detect vowel quality and quantity changes but also used them to activate memory traces associated with derivations. The present study therefore implies that morphology is directly involved in the Swedish stress system and that changes in phonological shape due to stress shift cue upcoming stress and potential addition of a morpheme.
Control of B cell development by Ras‐mediated activation of Raf

Cell fate commitment in a variety of lineages requires signals conveyed via p21ras. To examine the role of p21ras in the development of B lymphocytes, we generated transgenic mice expressing a dominant‐negative form of Ras in B lymphocyte progenitors, using a novel transcriptional element consisting of the Eμ enhancer and the lck proximal promoter. Expression of dominant‐negative Ras arrests B cell development at a very early stage, prior to formation of the pre‐B cell receptor. Furthermore, an activated form of Raf expressed in the same experimental system could both drive the maturation of normal pro‐B cells and rescue development of progenitors expressing dominant‐negative Ras. Hence p21ras normally regulates early development of B lymphocytes by a mechanism that involves activation of the serine/threonine kinase Raf.
Synchronization of Plasmodium falciparum gametocytes using an automated suspension culture system

SUMMARY An automated suspension culture system for the cultivation of Plasmodium falciparum is described which retains a degree of flexibility which is absent in other automated culture apparatuses. Not only does this system of cultivation promote rapid multiplication of asexual parasites but also permits the development and maturation of gametocytes. Using a combination of gelatin flotation and N-acetyl glucosamine treatment synchronous development of gametocytes was achieved. The total time for gametocyte maturation in vitro under the conditions provided was 7 days. Stages II and V required 48 h for development whilst I, III and IV needed 24 h each. Mature microgametocytes were relatively long lived in comparison with macrogametocytes. Electron microscopic study of the synchronized stages confirmed the observations of Sinden (1982) but, in addition, we noted the presence of Garnham bodies, a cytostome in all stages and dense spherules in stages I–III similar to the fenestrated buttons in sporozoites and exoerythrocytic forms. The relationship between the number of osmiophilic bodies in the mature gametocytes and their ability to escape from the red cell is reaffirmed.
Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells

Brain-derived neurotrophic factor (BDNF) is a small, basic protein purified from the mammalian brain that has been shown previously to support the survival of cultured spinal sensory neurons (Barde et al., 1982). In current studies, BDNF was tested for its ability to support the survival of cultured CNS cells isolated from the perinatal rat retina. Both immunofluorescent labeling of Thy-1 and prior retrograde labeling with HRP were used as retinal ganglion cell markers in vitro. With embryonic day (E) 17 retinas, it was found that BDNF allowed the survival of a small subpopulation of neurons (about 7% of the cells plated at this age) identified by the immunofluorescent labeling of Thy- 1. No detectable effects were seen when either the total number of cells or the number of tetanus toxin-positive neurons was measured. BDNF also had an effect on cultured neurons retrogradely labeled after HRP injections in the superior colliculi of neonatal rats. The BDNF- responsive population was therefore detected only in retinal cultures with specific markers and identified as consisting of retinal ganglion cells. These cells could be enriched about 80-fold by density gradient centrifugation, and purified ganglion cell cultures were shown to be responsive to BDNF. Whereas with E17 retinas, the number of surviving Thy-1 positive neurons could be kept constant for at least 4 d, the survival of postnatal neurons was only transiently increased by BDNF. We conclude that in the retina, BDNF affects only the survival of ganglion cells in vitro by a direct action on these cells. The results are discussed in terms of target-derived neurotrophic support during development.
An Optimal Retrospective Change Point Detection Policy

Abstract. Since the middle of the twentieth century, the problem of making inferences about the point in a surveyed series of observations at which the underlying distribution changes has been extensively addressed in the economics, biostatistics and statistics literature. Cumulative sum‐type statistics have commonly been thought to play a central role in non‐sequential change point detections. Alternatively, we present and examine an approach based on the Shiryayev–Roberts scheme. We show that retrospective change point detection policies based on Shiryayev–Roberts statistics are non‐asymptotically optimal in the context of most powerful testing.
DIRECTION FINDING IN THE PRESENCE OF NEAR ZONE RESONANT SIZE SCATTERERS

A self calibration algorithm for direction flnding in the presence of arbitrary shape 3D scatterers of resonating size is presented. This algorithm removes the efiects of mutual coupling and 3D scatterers on direction of arrival estimation. The scatterers and wire type antenna array are excited by incident plane waves of arbitrary direction. The 3D scatterers shape is approximated as a sphere, thus spherical harmonics are assumed to be originated in response to the plane wave excitation. The algorithm requires the location of the scatterers with reference to antenna elements. However, knowledge of exact shape of scatterers is not required. Moreover, scatterers may be located in near or far flelds. The work is supported by numerical examples for difierent scenarios of multiple incident waves and scatterers.
Variation in Gamma-Globin Expression before and after Induction with Hydroxyurea Associated with BCL11A, KLF1 and TAL1

The molecular mechanisms governing γ-globin expression in a subset of fetal hemoglobin (α2γ2: HbF) expressing red blood cells (F-cells) and the mechanisms underlying the variability of response to hydroxyurea induced γ-globin expression in the treatment of sickle cell disease are not completely understood. Here we analyzed intra-person clonal populations of basophilic erythroblasts (baso-Es) derived from bone marrow common myeloid progenitors in serum free cultures and report the level of fetal hemoglobin production in F-cells negatively correlates with expression of BCL11A, KLF1 and TAL1. We then examined the effects of hydroxyurea on these three transcription factors and conclude that a successful induction of γ-globin includes a reduction in BCL11A, KLF1 and TAL1 expression. These data suggests that expression changes in this transcription factor network modulate γ-globin expression in F-cells during steady state erythropoiesis and after induction with hydroxyurea.
Shallow Semantic Trees for SMT

We present a translation model enriched with shallow syntactic and semantic information about the source language. Base-phrase labels and semantic role labels are incorporated into an hierarchical model by creating shallow semantic "trees". Results show an increase in performance of up to 6% in BLEU scores for English-Spanish translation over a standard phrase-based SMT baseline.