Miracle-dz/UniFAR-FTUs huggingface dataset:
Adults' Knowledge about Memory: Awareness and Use of Memory Strategies across Tasks.

Two studies investigated college students' knowledge about the effectiveness of alternative memory strategies for different tasks and the relationship of this knowledge to strategy use and performance. In Experiment 1 students made paired-comparison judgments of the relative effectiveness of six strategies for increasing performance on one of three memory tasks. Experiment 2 examined the relationship of jugdments of strategy effectiveness to actual strategy use and memory performance
A Liver-Centric Multiscale Modeling Framework for Xenobiotics

We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen pharmacology and metabolism. We focus on a computational model to characterize whole body uptake and clearance, liver transport and phase I and phase II metabolism. We do this by incorporating sub-models that span three scales; Physiologically Based Pharmacokinetic (PBPK) modeling of acetaminophen uptake and distribution at the whole body level, cell and blood flow modeling at the tissue/organ level and metabolism at the sub-cellular level. We have used standard modeling modalities at each of the three scales. In particular, we have used the Systems Biology Markup Language (SBML) to create both the whole-body and sub-cellular scales. Our modeling approach allows us to run the individual sub-models separately and allows us to easily exchange models at a particular scale without the need to extensively rework the sub-models at other scales. In addition, the use of SBML greatly facilitates the inclusion of biological annotations directly in the model code. The model was calibrated using human in vivo data for acetaminophen and its sulfate and glucuronate metabolites. We then carried out extensive parameter sensitivity studies including the pairwise interaction of parameters. We also simulated population variation of exposure and sensitivity to acetaminophen. Our modeling framework can be extended to the prediction of liver toxicity following acetaminophen overdose, or used as a general purpose pharmacokinetic model for xenobiotics.
A New , More Powerful Approach to Multitrait-Multimethod Analyses : An Application of Second-order Confirmatory Factor Analysis

The advantages of applying confirmatory factor analysis (CFA) to multitrait-multimethod (MTMM) data are widely recognized. However, because CFA as traditionally applied to MTMM data incorporates single indicators of each scale (i.e., each trait/method combination), important weaknesses are the failure to: (1) correct appropriately for measurement error in scale scores; (2) separate error due to low internal consistency from uniqueness due to weak trait and/or method effects; (3) test whether items or subscales accurately reflect the intended factor structure; and (4) test for correlated uniquenesses. However, when the analy;is begins with multiple indicators of each scale (i.e., items or subscales), second-order factor analysis can be used to address each of these problems. In this approach first-order factors defined by multiple items or subscales are posited for each scale, and the method and trait factors are posited as second-order factors. This paper illustrates models that incorporate multiple indicators of each scale. The advantaot ) of their application are discussed. A three-page list o. references and the description of the models, mentioned in the text, supplement the paper. (Author/JAZ) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. *******;c*************************************************************** A New, More Powerful Approach to Multitrait-Multimethod Analyses: An Application of Second-order Confirmatory Factor Analysis
CHILDREN'S ESTIMATES OF PROPORTIONS

2 studies are described, both involving 6and 11-year Ss. The studies are concerned with variables affecting the relations between real and estimated proportions of elements. In the first study 2 categories of elements are employed, and in the second, 3. In each study, 4 problems are presented to each S. The results indicate that, in the 2-category study, the mean estimates of the age groups do not differ. At each age level, Ss were fairly accurate in their estimates, but showed a tendency to underestimate high proportions and overestimate low ones. In the 3-category study, Ss were again fairly accurate, except that 6-year Ss tended to overand underestimate to a significantly greater extent than 11-year Ss.
Morphological alterations in the synganglion and integument of Rhipicephalus sanguineus ticks exposed to aqueous extracts of neem leaves (Azadirachta indica A. JUSS)

Currently, the necessity of controlling infestation by ticks, especially by Rhipicephalus sanguineus, has led researchers and public health managers around the world to search for new and more efficient control methods. This way, we can highlight neem (Azadirachta indica A. Juss) leaf, bark, and seed extracts, which have been very effective on tick control, and moreover causing less damage to the environment and to the host. This study showed the potential of neem as a control method for R. sanguineus through morphological and morphometric evaluation of the integument and synganglion of females, in semiengorged stage. To attain this, routine techniques of optical microscopy, scanning electron microscopy and morphometry of the cuticle and subcuticle of the integument were applied. Expressive morphological alterations were observed in both organs, presenting a dose‐dependent effect. Integument epithelial cells and nerve cells of the synganglion showed signs of cell vacuolation, dilated intercellular boundaries, and cellular disorganization, alterations not previously reported in studies with neem. In addition, variations in subcuticle thickness were also observed. In general, the effects of neem are multiple, and affect the morphology and physiology of target animals in various ways. The results presented in this work are the first evidence of its effects in the coating and nervous system of ticks, thus allowing an indication of neem aqueous extracts as a potential control method of the brown dog tick and opening new perspectives on acaricide use. Microsc. Res. Tech. 77:989–998, 2014. © 2014 Wiley Periodicals, Inc.
Real-time physical activity and mental stress management with a wristband and a smartphone

Modern lifestyle is largely sedentary and often stressful, giving rise to extensive research and development of solutions for the management of these two lifestyle aspects. Physical activity monitoring is a mature area of ubiquitous computing, with many devices and mobile applications available on the market. Mental stress monitoring is still a hot research topic with few commercial solutions. This demo presents technology that goes beyond the state of the art in both areas, and powers a mobile application for lifestyle management.
Real-Time Transient Simulation Based on a Robust Two-Layer Network Equivalent

Real-time digital simulation of large power systems requires not only significant computational power but also simpler and accurate models. This paper proposes a new approach for transient simulation of power systems using a robust two-layer network equivalent model and an advanced PC-cluster based parallel real-time simulator. Using a combination of well established fitting and optimization methods, the generated low-order model is of high accuracy compared to its full model over a wide frequency bandwidth. The merits of this method are its robustness in terms of stability and positive-realness, its accuracy at not only transient frequencies but also at dc and power frequency, and its optimal order determination feature. To validate the new method, a realistic large-scale power system - the Alberta interconnected electric system - is simulated in real-time. The real-time electromagnetic transient program is implemented in C++ language using object-oriented programming techniques on the PC-cluster. A time-step of 20 mus has been used for the real-time simulation. The captured oscilloscope results demonstrate excellent accuracy and efficiency of the proposed model in comparison to a full-scale off-line simulation of the original system in the ATP version of EMTP.
Active principle of kimchi, 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid, retards fatty streak formation at aortic sinus of apolipoprotein E knockout mice.

We examined the beneficial effects of an active principle in kimchi, 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid (HDMPPA), on atherogenesis in apolipoprotein E knockout (apoE KO) mice. ApoE KO mice were fed an atherogenic diet containing 1% cholesterol (control group) with an intraperitoneal injection of chemically synthesized HDMPPA (10 mg/kg/day) (HDMPPA group) for 8 weeks. The aortic sinus atherosclerotic lesion size in the HDMPPA group (n = 10) was significantly smaller (control vs. HDMPPA, 280,790 vs. 165,409 microm(2), P < . 001). The level of reactive oxygen species (ROS) in the HDMPPA group was lower by 14%, compared with the control group (P < .05). Aortic NADPH oxidase activity was significantly lower in the HDMPPA group than in the control group. HDMPPA suppressed the mRNA expression of p47phox and rac-1 of NADPH oxidase by 27.2% and 46.0%, respectively, compared with values of the control group. In conclusion, HDMPPA in kimchi may attenuate atherosclerosis in apoE KO mice through retardation of ROS generation via down-regulating the mRNA expression of p47phox and rac-1, which are the components of NADPH oxidase.
An evidence-based review of edoxaban and its role in stroke prevention in patients with nonvalvular atrial fibrillation

Atrial fibrillation is the most common arrhythmia in the elderly. It is responsible for significant morbidity and mortality from cardioembolic complications like stroke. As a result, atrial fibrillation patients are risk-stratified using the CHADS2 or CHA2DS2-VASc scoring systems. Those at intermediate-to-high risk have traditionally been treated with therapeutic anticoagulation with warfarin for stroke prevention. Although effective, warfarin use is fraught with multiple concerns, such as a narrow therapeutic window, drug–drug and drug–food interactions, and excessive bleeding. Novel oral anticoagulant agents have recently become available as viable alternatives for warfarin therapy. Direct thrombin inhibitor dabigatran and factor Xa inhibitors like rivaroxaban and apixaban have already been approved by the US Food and Drug Administration (FDA) for stroke prevention in patients with nonvalvular atrial fibrillation. Edoxaban is the latest oral direct factor Xa inhibitor studied in the largest novel oral anticoagulant trial so far: ENGAGE AF-TIMI 48. Treatment with a 30 mg or 60 mg daily dose of edoxaban was found to be noninferior to dose-adjusted warfarin in reducing the rate of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, with a lower incidence of bleeding complications and cardiovascular deaths. Edoxaban was recently reviewed by an FDA advisory committee and recommended as a stroke-prophylaxis agent. Once approved, it promises to provide another useful alternative to warfarin therapy.
Policymakers' Online Use of Academic Research

In addressing the question of how new technologies can improve the public quality and presence of academic research, this article reports on the current online use of research by policymakers. Interviews with a sample of 25 Canadian policymakers at the federal level were conducted, looking at the specific role that online research has begun to play in their work, and what frustrations they face in using this research. The study found widespread use of online research, increasing the consultation of this source in policy analysis and formation. The principal issues remain those of access, indexing and credibility, with policymakers restricting themselves in large part to open access sources. Still, online research is proving a counterforce to policymakers' reliance on a small number of academic consultants as gatekeepers and sources for research. What is needed, it becomes clear, is investigations into whether innovative well-indexed systems that integrate a range of academic and non-academic resources might increase the political impact of research in the social sciences and education.
Broadening the functionality of a J-protein/Hsp70 molecular chaperone system

By binding to a multitude of polypeptide substrates, Hsp70-based molecular chaperone systems perform a range of cellular functions. All J-protein co-chaperones play the essential role, via action of their J-domains, of stimulating the ATPase activity of Hsp70, thereby stabilizing its interaction with substrate. In addition, J-proteins drive the functional diversity of Hsp70 chaperone systems through action of regions outside their J-domains. Targeting to specific locations within a cellular compartment and binding of specific substrates for delivery to Hsp70 have been identified as modes of J-protein specialization. To better understand J-protein specialization, we concentrated on Saccharomyces cerevisiae SIS1, which encodes an essential J-protein of the cytosol/nucleus. We selected suppressors that allowed cells lacking SIS1 to form colonies. Substitutions changing single residues in Ydj1, a J-protein, which, like Sis1, partners with Hsp70 Ssa1, were isolated. These gain-of-function substitutions were located at the end of the J-domain, suggesting that suppression was connected to interaction with its partner Hsp70, rather than substrate binding or subcellular localization. Reasoning that, if YDJ1 suppressors affect Ssa1 function, substitutions in Hsp70 itself might also be able to overcome the cellular requirement for Sis1, we carried out a selection for SSA1 suppressor mutations. Suppressing substitutions were isolated that altered sites in Ssa1 affecting the cycle of substrate interaction. Together, our results point to a third, additional means by which J-proteins can drive Hsp70’s ability to function in a wide range of cellular processes—modulating the Hsp70-substrate interaction cycle.
LINKING PROBABILITY TO REAL-WORLD SITUATIONS: HOW DO TEACHERS MAKE USE OF THE MATHEMATICAL POTENTIAL OF SIMULATION PROGRAMS?

In Quebec secondary schools, the teaching of probabilistic concepts is mandatory, but most teachers feel insufficiently prepared. Furthermore, middle school students are confronted to gambling activities at a young age, without necessarily understanding the underlying probability. In order to analyze the development of a more realistic and mathematically correct understanding of gambling activities, we conducted a one-year design experiment involving 4 high school teachers. We trained the participants in various concepts of probability and accompanied them to prepare classroom situations, which they used in their classrooms. In this paper, we analyze how the participating teachers used a simulation software we provided them. Mainly, the teachers used the software to show that gambling activities do not pay off over the long term. However, it was more difficult for the teachers to discuss probabilistic concepts through the simulation software.
Maximum likelihood estimator for Doppler parameter and cramer rao bound in ZP-OFDM UWA channel

A Doppler estimation system using a maximum likelihood criterion is presented in the context of underwater acoustic communications between moving transmitter/receiver. We simulate the method for the estimation of the Doppler effect induced by an underwater acoustic channel (UWA) using Zero Padded-Orthogonal Frequency Division Multiplexing (ZPOFDM). Among the wide range of physical processes that impact OFDM communications through the underwater environment, Doppler effect is an important cause of loss of orthogonality and must be compensated before discrete Fourier transform based demodulation can be performed. The proposed approach is based on the perfect knowledge of the emitted signal during one block and rely on the assumptions of a small variation of the Doppler effect induced by the canal between two ZP-OFDM blocks and, above all, during one block.
Are quorums an alternative for data replication?

Data replication is playing an increasingly important role in the design of parallel information systems. In particular, the widespread use of cluster architectures often requires to replicate data for performance and availability reasons. However, maintaining the consistency of the different replicas is known to cause severe scalability problems. To address this limitation, quorums are often suggested as a way to reduce the overall overhead of replication. In this article, we analyze several quorum types in order to better understand their behavior in practice. The results obtained challenge many of the assumptions behind quorum based replication. Our evaluation indicates that the conventional read-one/write-all-available approach is the best choice for a large range of applications requiring data replication. We believe this is an important result for anybody developing code for computing clusters as the read-one/write-all-available strategy is much simpler to implement and more flexible than quorum-based approaches. In this article, we show that, in addition, it is also the best choice using a number of other selection criteria.
Single-Cell Pharmacodynamic Monitoring of S6 Ribosomal Protein Phosphorylation in AML Blasts during a Clinical Trial Combining the mTOR Inhibitor Sirolimus and Intensive Chemotherapy

Purpose: Integration of signal transduction inhibitors into chemotherapy regimens generally has generally not led to anticipated increases in response and survival. However, it remains unclear whether this is because of inadequate or inconsistent inhibition of target or other complex biology. The mTOR signaling pathway is frequently activated in acute myelogenous leukemia (AML) and we previously showed the safety of combining the mTOR inhibitor, sirolimus, with mitoxantrone, etoposide, and cytarabine (MEC) chemotherapy. However, we did not reliably determine the extent of mTOR inhibition on that study. Here, we sought to develop an assay that allowed us to serially quantify the activation state of mTOR kinase during therapy. Experimental Design: To provide evidence of mTOR kinase activation and inhibition, we applied a validated whole blood fixation/permeabilization technique for flow cytometry to serially monitor S6 ribosomal protein (S6) phosphorylation in immunophenotypically identified AML blasts. Results: With this approach, we show activation of mTOR signaling in 8 of 10 subjects' samples (80%) and conclusively show inhibition of mTOR in the majority of subjects' tumor cell during therapy. Of note, S6 phosphorylation in AML blasts is heterogeneous and, in some cases, intrinsically resistant to rapamycin at clinically achieved concentrations. Conclusions: The methodology described is rapid and reproducible. We show the feasibility of real-time, direct pharmacodynamic monitoring by flow cytometry during clinical trials combining intensive chemotherapy and signal transduction inhibitors. This approach greatly clarifies pharmacokinetic/pharmacodynamic relationships and has broad application to preclinical and clinical testing of drugs whose direct or downstream effects disrupt PI3K/AKT/mTOR signaling. Clin Cancer Res; 18(6); 1716–25. ©2011 AACR.
Conditional Random Fields for Responsive Surface Realisation using Global Features

Surface realisers in spoken dialogue systems need to be more responsive than conventional surface realisers. They need to be sensitive to the utterance context as well as robust to partial or changing generator inputs. We formulate surface realisation as a sequence labelling task and combine the use of conditional random fields (CRFs) with semantic trees. Due to their extended notion of context, CRFs are able to take the global utterance context into account and are less constrained by local features than other realisers. This leads to more natural and less repetitive surface realisation. It also allows generation from partial and modified inputs and is therefore applicable to incremental surface realisation. Results from a human rating study confirm that users are sensitive to this extended notion of context and assign ratings that are significantly higher (up to 14%) than those for taking only local context into account.
Penalized spline models for functional principal component analysis

Summary. We propose an iterative estimation procedure for performing functional principal component analysis. The procedure aims at functional or longitudinal data where the repeated measurements from the same subject are correlated. An increasingly popular smoothing approach, penalized spline regression, is used to represent the mean function. This allows straightforward incorporation of covariates and simple implementation of approximate inference procedures for coefficients. For the handling of the within‐subject correlation, we develop an iterative procedure which reduces the dependence between the repeated measurements that are made for the same subject. The resulting data after iteration are theoretically shown to be asymptotically equivalent (in probability) to a set of independent data. This suggests that the general theory of penalized spline regression that has been developed for independent data can also be applied to functional data. The effectiveness of the proposed procedure is demonstrated via a simulation study and an application to yeast cell cycle gene expression data.
From a Distance: A Grounded Theory Study of Separation Anxiety Among Filipino Incarcerated Elderly

Despite numerous studies that examined the impact of separation and separation anxiety on the emotions and behavior of young individuals, little is known about separation anxiety in the elderly population. This grounded theory study purports to describe the process of separation anxiety among incarcerated Filipino elderly men. Individual interviews and participant observations were conducted with 25 incarcerated elderly Filipino men who are first-time prisoners and sentenced to lifetime imprisonment. Following Strauss and Corbin's (1998) coding protocol, a four-part process emerged to describe the studied layer of human experience. The Tectonic Model of Separation Anxiety among incarcerated Filipino elderly men comprises four phases: Winkling, Wilting, Weeding, and Weaving. Findings of this study invite nurses and other clinicians to identify developmentally appropriate strategies and interventions for this vulnerable and neglected sector of society.
Measurement of the K + → π + νν̄ branching fraction

A.V. Artamonov, B. Bassalleck, B. Bhuyan, ∗ E.W. Blackmore, D.A. Bryman, S. Chen, 4 I-H. Chiang, I. -A. Christidi, † P.S. Cooper, M.V. Diwan, J.S. Frank, T. Fujiwara, J. Hu, J. Ives, D.E. Jaffe, S. Kabe, S.H. Kettell, M.M. Khabibullin, A.N. Khotjantsev, P. Kitching, M. Kobayashi, T.K. Komatsubara, A. Konaka, A.P. Kozhevnikov, Yu.G. Kudenko, A. Kushnirenko, ‡ L.G. Landsberg, § B. Lewis, K.K. Li, L.S. Littenberg, J.A. Macdonald, § J. Mildenberger, O.V. Mineev, M. Miyajima, K. Mizouchi, V.A. Mukhin, N. Muramatsu, T. Nakano, M. Nomachi, T. Nomura, T. Numao, V.F. Obraztsov, K. Omata, D.I. Patalakha, S.V. Petrenko, R. Poutissou, E.J. Ramberg, G. Redlinger, T. Sato, T. Sekiguchi, T. Shinkawa, R.C. Strand, S. Sugimoto, Y. Tamagawa, R. Tschirhart, T. Tsunemi, ¶ D.V. Vavilov, B. Viren, Zhe Wang, 3 N.V. Yershov, Y. Yoshimura, and T. Yoshioka
Application of modified finite-difference formulas to the analysis of z-variant rib waveguides

Modified finite-difference formulas for a general position of an interface are applied to the propagating beam analysis of z-variant rib waveguides. The modified formula based on the semivectorial H-field is found to be more insensitive to variation in an interface position than that on the E-field. A discretization error is satisfactorily reduced in tilted and tapered rib waveguides.