Miracle-dz/UniFAR-FTUs huggingface dataset:
Local protein synthesis and GABAB receptors regulate the reversibility of long‐term potentiation at murine hippocampal mossy fibre–CA3 synapses

Reversal of long‐term potentiation (LTP) by long trains of low‐frequency stimulation is generally referred to as depotentiation. One of the intriguing aspects of depotentiation is that the magnitude of depotentiation is inversely proportional to the time lag of depotentiation stimulation following LTP induction. Although the mechanisms underlying depotentiation have been widely explored, the factors that regulate the susceptibility of LTP to depotentiation stimulation remain largely unclear. We now report that multiple trains of high‐frequency stimulation provide immediate synaptic resistance to depotentiation stimulation at the mossy fibre–CA3 synapses. The synaptic resistance to depotentiation stimulation depends on the amount of synaptic stimulation used to induce LTP; it is prevented by protein synthesis inhibitors and is input specific. In contrast, neither the transection of mossy fibre axons near granule cell somata nor the application of RNA synthesis inhibitors influences synaptic resistance to depotentiation stimulation. We also provide evidence that the induction of depotentiation is regulated by GABAB receptors. Application of a GABAB receptor antagonist significantly promoted the synaptic resistance to depotentiation stimulation, whereas inhibition of GABA transport delayed the onset of this synaptic resistance. These results suggest that local protein synthesis is required for the development of synaptic resistance to depotentiation stimulation, whereas the activation of GABAB receptors promotes the susceptibility to depotentiation stimulation. These two factors may crucially regulate the reversal and stability of long‐term information storage.
Design of CBNS Nibble Size adder using pass transistor logic circuit: Extension to FPGA implementation

This paper focuses on the design of CBNS Nibble Size adder for fast signal processing. A modular based approach has been undertaken both for Pass Transistor as well as Gate Level abstraction. The necessary interconnection between the modules has been done using the structural level design method in Verilog based on conceptual approach for CBNS addition. Simulation, both using ModelSim Altera Starter Edition 6.6d and Xilinx ISE design suite 13.4 confirms the logical verification of the proposed adder. Gate level implementation of the proposed adder on Spartan 3A, XC3S700A FPGA platform reveals 72.8 % reduction in number of LUTs and 51.4 % reduction in path delay over existing CBNS based circuits.
Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children

Catherine Liu,1 Arnold Bayer,3,5 Sara E. Cosgrove,6 Robert S. Daum,7 Scott K. Fridkin,8 Rachel J. Gorwitz,9 Sheldon L. Kaplan,10 Adolf W. Karchmer,11 Donald P. Levine,12 Barbara E. Murray,14 Michael J. Rybak,12,13 David A. Talan,4,5 and Henry F. Chambers1,2 1Department of Medicine, Division of Infectious Diseases, University of California-San Francisco, San Francisco, California; 2Division of Infectious Diseases, San Francisco General Hospital, San Francisco, CA, 3Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, 4Divisions of Emergency Medicine and Infectious Diseases, Olive View-UCLA Medical Center, Sylmar, CA; 5Department of Medicine, David Geffen School of Medicine at University of California Los Angeles; 6Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, Maryland; 7Department of Pediatrics, Section of Infectious Diseases, University of Chicago, Chicago, Illinois; 89Division of Healthcare Quality Promotion, Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; 10Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas; 11Division of Infectious Diseases, Beth Israel Deaconess Medicine Center, Harvard Medical School, Boston, Massachusetts; 12 Department of Medicine, Division of Infectious Diseases, Wayne State University, Detroit Receiving Hospital and University Health Center, Detroit, Michigan; 13Deparment of Pharmacy Practice, Wayne State University, Detroit Michigan; and 14Division of Infectious Diseases and Center for the Study of Emerging and Re-emerging Pathogens, University of Texas Medical School, Houston, Texas
An empirical study of critical success factors in IT projects

This paper presents empirical research aimed at studying the most critical success factors in Information Technology (IT) projects. Several studies show that many IT projects have difficulties meeting their performance goals. This paper reviews the literature and presents significant contributions to the discussion of what factors play an important role in achieving successful IT projects. Results from a survey in Norway on IT projects show that the five most important success factors are: (1) top management support; (2) end-user involvement; (3) a clear project goal; (4) good communication and feedback from involved parties; (5) clear responsibilities.
Job scheduling based on reliability, time and cost constraints under Grid environment

The advent of Grid environments made feasible the solution of computational intensive problems in a reliable and cost-effective way. As scheduling carry out more complex and mission-critical applications, Quality of Service (QoS) analysis serves to ensure that each application meets user requirements. In that frame, author presents a novel Ant colony algorithm with a quick convergence of ant to move from source to destination which allows the mapping of job processes to Grid provided services assuring at the same time end-to-end provision of QoS (cost, makespan and reliability) based on user-defined parameters and preferences. Paper also demonstrate the operation of the implemented algorithm using three different heuristics and evaluate its effectiveness using a Grid scenario.
The Impact of Oil Price Shocks on the Stock Market Return and Volatility Relationship

This paper examines the impact of structural oil price shocks on the covariance of U.S. stock market return and stock market volatility. We construct from daily data on return and volatility the covariance of return and volatility at monthly frequency. The measures of daily volatility are realized-volatility at high frequency (normalized squared return), conditional-volatility recovered from a stochastic volatility model, and implied-volatility deduced from options prices. Positive shocks to aggregate demand and to oil-market specific demand are associated with negative effects on the covariance of return and volatility. Oil supply disruptions are associated with positive effects on the covariance of return and volatility. The spillover index between the structural oil price shocks and covariance of stock return and volatility is large and highly statistically significant.
Non-Tariff Measures When Alternative Regulatory Tools Can Be Chosen

Abstract This paper analyzes whether or not different non-tariff measures (NTM) like a standard or a mandatory label can be considered as protectionist in presence of market imperfections. From a welfare-based approach, protectionism occurs when the instrument maximizing domestic welfare is different from the alternative instrument maximizing international welfare inclusive of foreign profits. A framework taking into account different tools shows the complexity for characterizing protectionism related to different NTM. When the standard impacts variable costs, the mandatory label can be protectionist. When the standard impacts sunk costs, the standard can be protectionist. The framework is also useful for empirically characterizing the impact of NTM related to a specific product. An application to shrimp trade illustrates the feasibility of the welfare measure, for an ex ante evaluation of possible environmental regulations that could be implemented in the future. This application confirms that the tool maximizing domestic welfare does not systematically correspond to the tool maximizing international welfare.
Education for Aboriginal Learners: Challenges and Suggestions as Perceived by School Principals

According to school principals, the purpose of this paper is to identify issues that negatively influence the educational experience of Aboriginal students and to offer real-life examples focused on addressing these challenges. This qualitative multi-case study encapsulates 14 semi-structured individual interviews conducted with five Saskatchewan principals and four Prince Edward Island principals. From the perspective of nine shcool principals, challenges were pedagogical and curricular issues, student transition and attendance, the legacy of residential schools and other parental issues, and financial resource issues. Implications of the study pertain to professional development of teachers and hiring procedures of school districts.
Bis[2-(1H-imidazol-2-yl-κN 3)-1H-imidazol-3-ium]silver(I) trinitrate

The synthesis of the title salt, [Ag(C6H7N4)2](NO3)3, was carried out employing a 1:2 molar ratio of 2,2′-biimidazole and silver nitrate respectively. The cation has crystallographically-imposed C2 symmetry with the metal atom in an almost linear coordination environment [N—Ag—N = 177.01 (17)°]. The crystal structure displays N—H⋯O and C—H⋯O hydrogen-bonding interactions.
Market meltdown and the propagation mechanism of contagion

World economy came on a tailspin because of market meltdown and the propagation of contagion triggered by recession, starting mostly from the US economy. This work highlights the grim developments in thenancial sectors and the real sectors world-wide, and then an attempt is made to highlight the propagation mechanism of infective contagion. Theoretical structures of such interconnected are showcased through various analytical vehicles. The indices of sensitivities and dispersions are measured in mathematical terms, and in that sense a new analytical framework is presented. However, empirical evaluations of the propagation mechanism remain unnished because of the dearth of data
Population Growth, Technological Adoption, and Economic Outcomes in the Information Era

In this paper we argue that population growth, through its interaction with recent technological and organizational developments, may account for many cross-country differences in economic outcomes observed among industrialized countries over the past 20 years. In particular, our model illustrates how a large decrease in the price of information technology can create a comparative advantage for high population growth economies to jump ahead in the adoption of computer- and skill-intensive modes of production. They do this as a means of countering their relative scarcity of physical capital. The predictions of the model are that, over the span of the information revolution, industrial countries with higher population growth rates will experience a more pronounced adoption of new technology, a better performance in terms of increased employment rates, a poorer performance in terms of wage growth for less skilled workers, a larger increase in the service sector, and a larger increase in the returns to education. We provide preliminary evidence in support of the theory based on an examination of broad wage movements, employment changes, and computer adoption patterns for a set of OECD countries. (Copyright: Elsevier)
Geometric Component in Constant-Amplitude Charge-Pumping Characteristics of LOCOS- and LDD-MOSFET Devices

In this paper, we develop a semianalytical model that predicts the geometric component in charge-pumping (CP) measurements for local oxidation of silicon (LOCOS) and lightly doped drain (LDD) transistors. It is not only based on thermal diffusion, drift field, and self-induced drift field but also on the contribution of the active CP area and the low-level voltage (VL) of the gate signal. By adding this model to constant-amplitude CP components, such as LOCOS, LDD, and effective channel regions, we will be able to compute ICP-VL characteristics of LDD-MOSFET devices with LOCOS structure. In addition, we compare the geometric component model against numerous experimental data obtained from transistors of different gate lengths and widths. The calculated ICP- VL characteristics with geometric component model are found in good correlation with the experimental ICP- VL data and are more accurate than the calculated CP without the geometric component. This modeling approach can be extended for MOSFET stress reliability evaluation such as negative bias temperature instability and radiation degradations.
KeyRanker: Automatic RDF Key Ranking for Data Linking

Automatic approaches to key discovery on RDF datasets generate sets of discriminative properties that can be used to configure data linking systems relying on link specifications. These keys often come in large numbers, generated independently for two datasets to be linked, lacking an assessment of their usefulness for the linking task. We propose a novel generic algorithm for selecting keys, valid in two datasets, and ranking them with respect to their individual likelihood to generate identity links. In addition, we explore the combined use of several complementary keys improving their individual performance. We evaluate our approach on diverse synthetic and real-world benchmark data, showing its robustness with respect to different linking tools and domains.
Pediatric Emergency Department Management Benefits From Appropriate Early Redirection of Nonurgent Visits

Aims Overcrowding at pediatric emergency departments (EDs) may result in delayed clinical management and higher risks of medical error. This study was designed to prospectively evaluate what parents of sick children seek emergency care for and how these patients are being assessed and managed. Methods Patients aged 0 to 17 years seeking ED care at an urban Swedish university hospital, from 8 AM to 9 PM on 25 consecutive days, were included. Clinical urgency and further level of medical care were determined by experienced nurses based on individual clinical signs and vital parameters. Information on presenting problem, medical priority, gender, age, waiting time, day of week, time of day, and further management was recorded. Results Among 1057 included children, two thirds were assessed by physicians, whereas one third were referred directly by nurses for other ED (n = 54) or primary care (n = 114), or sent home with medical advice (n = 176), more often during evenings and weekends. Of primarily referred patients, 7.6% returned within 72 hours, and three of them were admitted. Young infants, patients with respiratory or neurological problems, and sicker patients with fever or infections were mainly assessed by physicians, within desired priority time. Discussion More than one fourth of pediatric ED patients might rapidly, appropriately, and safely be referred for primary care or sent home by experienced pediatric nurses soon after arrival, thereby facilitating management of urgent and more appropriate patients. Evaluations by physicians were primarily required in young infants and for urgent medical conditions demanding qualified pediatric skills.
Organizational learning and organizational commitment: A correlational study in manufacturing context

This paper aims to investigate the impact of organizational learning (OL) on organizational commitment (OC). Learning is the key element needed by all organizations that wants to develop and sustain competitive advantage in the new knowledge economy. This paper focuses on the relationships between organizational learning and organizational commitment, a little researched area, specifically, in Pakistani perspective. Data were collected from one hundred and seventy seven randomly selected employees from three manufacturing organizations. Structural Equation Modeling (SEM) was used to test the hypotheses. Findings revealed that organizational commitment is positively predicted by organizational learning. Results suggests that to keep pace with the changing environment, organizations need to remain flexible and improve their employees’ commitment via OL in gaining and sustaining competitive advantage to ensure growth and profitability in long-run. Further, data does not support the positive role of leadership in defining organizational learning in Pakistani context. Key words: Organizational learning, organizational commitment, Pakistan, Structural Equation Modeling (SEM).
The National Hockey League and Cross-Border Fandom

This article uses daily border-crossing data within the Niagara region of Ontario and New York to evaluate the Canadian market for a U.S.-based National Hockey League (NHL) team, the Buffalo Sabres. We conservatively estimate that 15% of attendees at Buffalo Sabres home games travel from Canada. This effect is heterogeneous with respect to the opponent country of origin, with higher levels of game day border crossing associated with a Canadian visiting team. We also find fan substitution effects between Buffalo and the Toronto Maple Leafs with respect to both the price of attendance and the quality of each team. Implications extend to NHL expansion near international borders and compensation to incumbent teams both within and across the national border near where an expansion or relocated team is placed.
Sentiment Analysis for Mobile SNS Data

Everyday a lot of diverse data have been generated every day regarding individual opinions and preferences on the contents of Social Network Service (SNS). These data could affect greatly to various fields of our society such as politics, public opinions, economics, services and entertainments. It is necessary to extract new information from SNS data and to understand the true intention of users or customers. To extract important information, it is required to several techniques to analyze a large amount of SNS data, extract meaningful data from them, and generate new information. This paper presents an efficient method that can process various unstructured big data on social networks, and extract the information for sentiment and generate preferences of users from sentiment information. The proposed method shows O(n) processing time as the number of data increases.
Putting the state in its place: US foreign policy and differential capital accumulation in Middle East 'energy conflicts'

This is the second in a series of two articles looking into the interaction between differential capital accumulation and Middle East 'energy conflicts'. Examining the historical record since the late 1960s, we find US policies to have been increasingly consistent with the coinciding differential interests of a Weapondollar-Petrodollar coalition of large defence contractors and oil companies. Contrary to aggregate views which emphasize the 'national interest' or the broad imperatives of capital accumulation - but in line with the differential interests of these companies - US policies in the region seem to have contributed towards greater instability, imposed limits on the free flow of oil and led to higher unstable prices. Most significantly, every 'energy conflict' since the late 1960s was preceded by adverse drops in the differential rate of profit of the large oil companies, which then promptly recovered in the wake of the ensuing crisis. While the US government was officially seeking regional conciliation, it passively or actively endorsed each one of these conflicts. The current peace drive between Israel and its Arab neighbours is overshadowed by negative differential profits for the oil companies and depressed weapon sales for the arms contractors. Left unresolved, these predicaments could eventually culminate in a new 'energy conflict'.
Damage Control Productivity: Why Econometrics Matters

For nonexperimental data, asymmetric specifications of the role of damage control inputs impose restrictions of homotheticity or nonjointness on the underlying technology. A generalized symmetric form where damage control inputs affect factor diminution functions motivates use of symmetric specifications. Panel data and estimation methods are presented to produce robust estimates of damage control productivity that are free of heterogeneity bias. Estimates of the productivity of pesticides for French cereal farm production illustrate that fixed firm and time effects are important. Estimates indicate substantially smaller marginal productivity of pesticides than reported by past studies. Copyright 1997, Oxford University Press.
Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia.

BACKGROUND In a randomized trial, 1106 patients with chronic myeloid leukemia (CML) in chronic phase were assigned to imatinib or interferon alfa plus cytarabine as initial therapy. We measured levels of BCR-ABL transcripts in the blood of all patients in this trial who had a complete cytogenetic remission. METHODS Levels of BCR-ABL transcripts were measured by a quantitative real-time polymerase-chain-reaction assay. Results were expressed relative to the median level of BCR-ABL transcripts in the blood of 30 patients with untreated CML in chronic phase. RESULTS In patients who had a complete cytogenetic remission, levels of BCR-ABL transcripts after 12 months of treatment had fallen by at least 3 log in 57 percent of those in the imatinib group and 24 percent of those in the group given interferon plus cytarabine (P=0.003). On the basis of the rates of complete cytogenetic remission of 68 percent in the imatinib group and 7 percent in the group given interferon plus cytarabine at 12 months, an estimated 39 percent of all patients treated with imatinib but only 2 percent of all those given interferon plus cytarabine had a reduction in BCR-ABL transcript levels of at least 3 log (P<0.001). For patients who had a complete cytogenetic remission and a reduction in transcript levels of at least 3 log at 12 months, the probability of remaining progression-free was 100 percent at 24 months, as compared with 95 percent for such patients with a reduction of less than 3 log and 85 percent for patients who were not in complete cytogenetic remission at 12 months (P<0.001). CONCLUSIONS The proportion of patients with CML who had a reduction in BCR-ABL transcript levels of at least 3 log by 12 months of therapy was far greater with imatinib treatment than with treatment with interferon plus cytarabine. Patients in the imatinib group with this degree of molecular response had a negligible risk of disease progression during the subsequent 12 months.
Modelling Business Travel

Business travel is important and yet very few attempts have been made to model it. The aim of this study is to identify those economic variables that are most important in influencing business trips to Australia from four of Australia's most important travel and trade partners. Using a standard demand modelling approach suitably modified to deal with the motivations for business trips, Johansen's Full Information Maximum Likelihood technique is used to estimate the long-run relationship between business travel and its explanators. We find that the importance of the economic variables varies from country to country, although overall openness to trade and origin country real income are important variables explaining business travel.