Miracle-dz/UniFAR-FTUs huggingface dataset:
Dominican Immigrants and Discrimination in a New Destination: The Case of Reading, Pennsylvania

The last decade has witnessed the diversification of immigrant destinations in the United States. Although the literature on this phenomenon is burgeoning, research on the experiences of smaller immigrant groups in new destinations is underdeveloped. This is especially the case for those from the Dominican Republic, a group that is expanding beyond the traditional gateway cities of the Northeast. Using a survey of Dominican immigrants in Reading, Pennsylvania, this study has two objectives. the first objective is to describe the prevalence of experiences with institutional and interpersonal discrimination. the second objective is to determine the extent to which these experiences are structured around racial markers (i.e., skin tone), forms of capital, forms of incorporation, and exposure to the United States. Our results show that a substantial minority of Dominican immigrants claims to have been treated unfairly, primarily because of their “race and ethnicity. ” in addition, experiences with some types of discrimination are positively associated with skin tone (i.e., darkness) and several factors that are identified in models of assimilation.
Diagnostic Radiation Exposure of Injury Patients in the Emergency Department: A Cross-Sectional Large Scaled Study

In contrast to patients with underlying cancer or chronic disease, injury patients are relatively young, and can be expected to live their natural lifespan if injuries are appropriately treated. Multiple and repeated diagnostic scans might be performed in these patients during admission. Nevertheless, radiation exposure in injury patients has been overlooked and underestimated because of the emergent nature of such situations. Therefore, we tried to assess the cumulative effective dose (cED) of injury patients in the emergency department. We included patients who visited the emergency department (ED) of a single tertiary hospital due to injury between February 2010 and February 2011. The cED for each patient was calculated and compared across age, sex and injury mechanism. A total of 11,676 visits (mean age: 28.0 years, M:F = 6,677:4,999) were identified. Although CT consisted of only 7.8% of total radiologic examinations (n=78,025), it accounted for 87.1% of the total cED. The mean cED per visit was 2.6 mSv. A significant difference in the cED among injury mechanisms was seen (p<0.001) and patients with traffic accidents and fall down injuries showed relatively high cED values. Hence, to reduce the cED of injury patients, an age-, sex- and injury mechanism-specific dose reduction strategy should be considered.
Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest

ABSTRACT PDCD2 (programmed cell death domain 2) is a highly conserved, zinc finger MYND domain-containing protein essential for normal development in the fly, zebrafish and mouse. The molecular functions and cellular activities of PDCD2 remain unclear. In order to better understand the functions of PDCD2 in mammalian development, we have examined PDCD2 activity in mouse blastocyst embryos, as well as in mouse embryonic stem cells (ESCs) and embryonic fibroblasts (MEFs). We have studied mice bearing a targeted PDCD2 locus functioning as a null allele through a splicing gene trap, or as a conditional knockout, by deletion of exon2 containing the MYND domain. Tamoxifen-induced knockout of PDCD2 in MEFs, as well as in ESCs, leads to defects in progression from the G1 to the S phase of cell cycle, associated with increased levels of p53 protein and p53 target genes. G1 prolongation in ESCs was not associated with induction of differentiation. Loss of entry into S phase of the cell cycle and marked induction of nuclear p53 were also observed in PDCD2 knockout blastocysts. These results demonstrate a unique role for PDCD2 in regulating the cell cycle and p53 activation during early embryonic development of the mouse.
High gain channel coding for satellite communication system

The main aim of this work is to find a way to replace the current coding scheme implemented on AlSat-2; the second earth observation Algerian Microsatellite (2.5 m of resolution), to be implemented on the future high resolution earth observation Algerian Microsatellite, by the discovered Turbo Codes. This paper describes the performance of the Turbo Code - Binary Phase Shift Keying (BPSK) Modem which was designed at the Centre of Satellite Development (CDS). This proof-of-concept modem is the outcome of a research and development (R&D) project entitled “Design of a smart adaptive communication system for the future satellite communication systems”. The major technical contribution of this work is the new interleaver design using chaotic sequences to produce the dither in the golden interleaver. We compare the performance of Turbo codes for different interleaver sizes and a number of iteration equal to five with the performance of the industry standard rate 1/2, constraint length (K) seven, convolutional code. As example and for practical considerations, the interleaver length is fixed to be equal to 1024. To achieve a bit error rate (BER) of 10-5, a gain of about 3dB is reached when we replace the current scheme (convolutional encoder) with the suggested Turbo encoder.
Theory in Furs

Was will die Anthropologie? Freuds analysis of masochism can serve as a lens with which to explore the longstanding anthropological interest in powerless or disenfranchised people. Recent anthropological work can be examined not only in the terms encouraged by its own diegesis as a relation between anthropologist and the powerless but also as elements in a constellation that includes anthropology as a discipline and capitalism. Exploration of the libidinal structure within which our discipline has taken shapethat is to say, the structure that gives not just possibility and meaning but also pleasure to the practice of anthropologycan shed light on the nature of the pleasure that anthropologists derive from identification with the powerless.
Differential Role of Pim-1 Kinase in Anesthetic-induced and Ischemic Preconditioning against Myocardial Infarction

Background:Ischemic preconditioning (IPC) and anesthetic-induced preconditioning against myocardial infarction are mediated via protein kinase B. Pim-1 kinase acts downstream of protein kinase B and was recently shown to regulate cardiomyocyte survival. The authors tested the hypothesis that IPC and anesthetic-induced preconditioning are mediated by Pim-1 kinase. Methods:Pentobarbital-anesthetized male C57Black/6 mice were subjected to 45 min of coronary artery occlusion and 3 h of reperfusion. Animals received no intervention, Pim-1 kinase inhibitor II (10 &mgr;g/g intraperitoneally), its vehicle dimethyl sulfoxide (10 &mgr;l/g intraperitoneally), or 1.0 minimum alveolar concentration desflurane alone or in combination with Pim-1 kinase inhibitor II (10 &mgr;g/g intraperitoneally). IPC was induced by three cycles of 5 min ischemia–reperfusion each, and animals received IPC either alone or in combination with Pim-1 kinase inhibitor II (10 &mgr;g/g intraperitoneally). Infarct size was determined with triphenyltetrazolium chloride, and area at risk was determined with Evans blue (Sigma-Aldrich, Taufkirchen, Germany). Protein expression of Pim-1 kinase, Bad, phospho-BadSer112, and cytosolic content of cytochrome c were measured using Western immunoblotting. Results:Infarct size in the control group was 47 ± 2%. Pim-1 kinase inhibitor II (44 ± 2%) had no effect on infarct size. Desflurane (17 ± 3%) and IPC (19 ± 2%) significantly reduced infarct size compared with control (both P < 0.05 vs. control). Blockade of Pim-1 kinase completely abrogated desflurane-induced preconditioning (43 ± 3%), whereas IPC (35 ± 3%) was blocked partially. Desflurane tended to reduce cytosolic content of cytochrome c, which was abrogated by Pim-1 kinase inhibitor II. Conclusion:These data suggest that Pim-1 kinase mediates at least in part desflurane-induced preconditioning and IPC against myocardial infarction in mice.
Control of oocyte release by progesterone receptor-regulated gene expression

The progesterone receptor (PGR) is a nuclear receptor transcription factor that is essential for female fertility, in part due to its control of oocyte release from the ovary, or ovulation. In all mammals studied to date, ovarian expression of PGR is restricted primarily to granulosa cells of follicles destined to ovulate. Granulosa cell expression of PGR is induced by the pituitary Luteinizing Hormone (LH) surge via mechanisms that are not entirely understood, but which involve activation of Protein Kinase A and modification of Sp1/Sp3 transcription factors on the PGR promoter. Null mutations for PGR or treatment with PGR antagonists block ovulation in all species analyzed, including humans. The cellular mechanisms by which PGR regulates ovulation are currently under investigation, with several downstream pathways having been identified as PGR-regulated and potentially involved in follicular rupture. Interestingly, none of these PGR-regulated genes has been demonstrated to be a direct transcriptional target of PGR. Rather, in ovarian granulosa cells, PGR may act as an inducible coregulator for constitutively bound Sp1/Sp3 transcription factors, which are key regulators for a discrete cohort of ovulatory genes.
Introducing Newborn Screening for Severe Combined Immunodeficiency (SCID) in the Dutch Neonatal Screening Program

The implementation of newborn screening for severe combined immunodeficiency (SCID) in the Netherlands is a multifaceted process in which several parties are involved. The Dutch Ministry of Health adopted the advice of the Dutch Health Council to include SCID in the Dutch newborn screening program in 2015. As newborn screening for SCID is executed with a new, relatively expensive assay for the Dutch screening laboratory, an implementation pilot study is deemed instrumental for successful implementation. A feasibility study was performed in which the practicalities and preconditions of expanding the newborn screening program were defined. Cost-effectiveness analysis (CEA) indicated that SCID screening in the Netherlands might be cost-effective, recognizing that there are still many uncertainties in the variables underlying the CEA. Data and experience of the pilot study should provide better estimates of these parameters, thus enabling the actualization of CEA results. Prior to the implementation pilot study, a comparison study of two commercially available SCID screening assays was performed. A prospective implementation pilot study or so-called SONNET study (SCID screening research in the Netherlands with TRECs) started in April 2018 and allows the screening for SCID of all newborns in three provinces of the Netherlands for one year. Based on the results of the SONNET study, the Dutch Ministry of Health will make a final decision about national implementation of newborn screening for SCID in the Netherlands.
Covariance Maximized Lambda 4 : An Introduction of a Low-Biased Reliability Coefficient

Combining the strengths of coefficient alpha and maximized reliability coefficients, this paper introduces an estimator based on a maximization method that utilizes a covariance matrix to obtain a subset of split-half reliabilities. The mean of the vector of split-half reliabilities can then be used to estimate reliability. Only the maximum of this vector (Guttman’s maximal λ4) has been explored previously despite evidence that it may overestimate reliability in small samples. Computation theory, algorithm and code based in R are provided for computation for the estimator. Simulations were used to assess the performance of the estimator in a variety of data structures while also allowing direct comparisons to the greatest lower bound, Mcdonald’s omega, and coefficient alpha.
They won’t listen to me: Anticipated power and women’s disinterest in male-dominated domains

We hypothesized that women avoid male-dominated domains because they anticipate lacking the power to influence others in those contexts. In Study 1, a questionnaire study, male undergraduates were more interested in science, technology, engineering, and mathematics (STEM) majors than were female undergraduates, and this gender disparity was mediated by women anticipating having less power in STEM fields than men did. Study 2 experimentally demonstrated that a lack of female representation within an academic context (MBA program) led women to infer that they would lack power in that context. Consequently, they became less interested in the program and in business schools in general. Our findings indicate that expecting low interpersonal power is an important mechanism by which women lose interest in pursuing male-dominated fields.
Optimizing expressway maintenance planning by coupling ant algorithm and geography information system transportation in Hubei province, China

Highway maintenance scheduling is a complex optimization problem and imposes a challenge for GIS-T research. In this paper, a new approach was put forward to determining the optimal set of alternatives for highway infrastructure facilities by using ant colony algorithm and GIS. In the proposed approach, GIS was used to analyze traffic flux, toll and maintenance time of each highway segment. Meanwhile, an ant colony algorithm was applied to resolve the computational complexity of multi-objective large-size scheduling optimization problems. Experiments were performed in national highways in the Hubei province by the proposed method. The application illustrated the feasibility, efficiency, and capability of coupling ant algorithm and geography information system transportation for multi-objective expressway maintenance planning optimization.
Psychological growth in humanitarian aid personnel: reintegrating with family and community following exposure to war and genocide

There is a paucity of research into the subjective experiences of humanitarian aid personnel exposed to modern global conflicts and disasters in the course of their work. In particular, little is known about how they make sense of any dual threat: (1) witnessing catastrophic and traumatic events perpetrated on those they seek to serve and (2) experiencing personal threat to self. This phenomenological study explores the idiographic interpretation of aid personnel working in complex humanitarian settings including exposure to genocide, and the impact of such exposure on reintegration processes postmission. Semi-structured interviews were conducted, and data were analyzed using interpretative phenomenological analysis (IPA). One theme: Complex humanitarian distress and growth overarched five subordinate themes. Four of the subordinate themes highlighted long term psychological distress including shame, moral doubt, betrayal, and narcissistic coping. The fifth theme, Reparation with ‘self’, describes a redefining of self-worth and altruistic identity over time despite earlier perceived moral failure and sense of rejection from organization and important others. Reparation with self, as a positive outcome from traumatic distress and lack of validating support from important others, is discussed in light of current posttraumatic growth literature. Implications for therapists and recruiting organizations are also discussed.
When Acceptance is not Enough - Taking TAM-Model into Healthcare

Information technology is diversing in healthcare and with it raises the need to diverse the evaluation as well. Individual impacts are often neglected when evaluating IT at work. Healthcare is a stressful sector and besides the traditional stress, exposed to IT related stress due its structure and personnel. In this paper some general needs for re-evaluating of IT evaluation are addressed. Moreover a new perspectiv- IT related stress- is presented to broad the evaluation. The main purpose of this paper is to develop a theoretical model based on widely used TAM-model to evaluate IT stress as a factor of IT acceptance.
IMPLEMENTATION DIFFERENCES OF TWO STAFFING MODELS IN THE GERMAN HOME VISITING PROGRAM "PRO KIND"

As different competencies or professional backgrounds may affect the quality of program implementation, staffing is a critical issue in home visiting. In this study, N = 430 women received home visits delivered either by a tandem of a midwife and a social worker or by only one home visitor (primarily midwives, continuous model). The groups were compared in a quasi-experimental design on level of participation, implementation of the contents, and clients’ responsiveness during pregnancy and child’s first year of life. Trends towards a higher dropout rate and lower ratings of the helping relationship indicate an increased challenge to retain a strong working alliance in the tandem model. This is attributable to a stronger orientation towards the participants’ interest in the continuous model, whereas treatment fidelity in the tandem model is higher. Recommendations to improve the helping relationship in the tandem model are given. C
A Krüppel-like factor KLF15 Contributes Fasting-induced Transcriptional Activation of Mitochondrial Acetyl-CoA Synthetase Gene AceCS2*

Acetyl-CoA synthetase 2 (AceCS2) produces acetyl-CoA for oxidation through the citric acid cycle in the mitochondrial matrix. AceCS2 is highly expressed in the skeletal muscle and is robustly induced by fasting. Quantification of AceCS2 transcripts both in C2C12 and human myotubes indicated that fasting-induced AceCS2 gene expression appears to be independent on insulin action. Characterization of 5′-flanking region of the mouse AceCS2 gene demonstrates that Krüppel-like factor 15 (KLF15) plays a key role in the trans-activation of the AceCS2 gene. Deletion and mutation analyses of AceCS2 promoter region revealed that the most proximal KLF site is a curtail site for the trans-activation of the AceCS2 gene by KLF15. Using Sp-null Drosophila SL2 cells, we showed that the combination of KLF15 and Sp1 resulted in a synergistic activation of the AceCS2 promoter. Mutation analyses of three GC-boxes in the AceCS2 promoter indicated that the GC-box, located 8 bases downstream of the most proximal KLF15 site, is the most important GC-box in the synergistic trans-activation of the AceCS2 gene by KLF15 and Sp1. GST pull-down assays showed that KLF15 interacts with Sp1 in vitro. Quantification of various KLF transcripts revealed that 48 h fasting robustly induced the KLF15 transcripts in the skeletal muscle. Together with the trans-activation of the AceCS2 promoter, it is suggested that fasting-induced AceCS2 expression is largely contributed by KLF15. Furthermore, KLF15 overexpression induced the levels of AceCS2 transcripts both in myoblasts and in myotubes, indicating that AceCS2 gene expression in vivo is indeed induced by KLF15.
The Clinical Supervisor-Practitioner Working Alliance

Abstract The focus of my presentation this morning is the core dynamics and skills of the supervisor-practitioner working alliance, or what I will refer to as the working relationship. I will present a model that suggests that the use of certain communication, relationship and problem-solving skills by the supervisor can influence the development of a positive working relationship with the supervisee, and that this working relationship is the medium through which the supervisor influences the practitioner. I stress the words “influence” because a central assumption of this approach is that both supervision and direct practice are interactional in nature. The supervisor and the supervisee each play a part in the process. The outcome of supervision is the result of how well each contributes to the process. This morning's presentation focuses on the supervisor's role. One of the discussions is the concept of the “parallel process. ” While the role of the supervisor and the purpose of supervision are quite different from counseling and therapy, nevertheless there are striking parallels in the dynamics and skills. There is a suggestion that “more is caught than taught” and that our supervisees watch us very closely. Whether we like it or not, whether we are aware of it or not, our supervisees learn more about practice from the way we work with them than from what we say about their actual practice. Supervision is not therapy. In fact, supervisors who are seduced into a therapeutic relationship with their supervisees actually model poor practice since they lose sight of the true purpose of clinical supervision and their role in the process.
Work hard, sleep well - Avoid irreversible IC wearout with proactive rejuvenation

Various wearout mechanisms have both a reversible and an irreversible (permanent) part, with some, like BTI and EM having a significant reversible part, while others, like HCI, being mostly irreversible. In this paper we make two contributions. First, we show that the boundary between the reversible and irreversible parts of wearout is not fixed, with the irreversible part becoming at least partially reversible under the right conditions of active accelerated recovery and stress/recovery scheduling. Second, we show that there are certain stress/recovery schedules that can (almost) completely eliminate irreversible wearout, thus allowing significant reductions in necessary design margins. The experiments were done on commercial FPGAs fabricated in a 40nm technology. To fully repair and avoid the irreversible wearout, we propose a biology-inspired sleep-when-getting-tired strategy. The strategy can achieve >60× design margin reduction and ~9% average performance improvement within a 10-year lifetime constraint compared to the no-recovery case. Potential system level implementations (a negative “turbo-boost” like strategy) in multicore and NoC systems are also presented.
Deformable models with parameter functions for cardiac motion analysis from tagged MRI data

The authors present a new method for analyzing the motion of the heart's left ventricle (LV) from tagged magnetic resonance imaging (MRI) data. Their technique is based on the development of a new class of physics-based deformable models whose parameters are functions. They allow the definition of new parameterized primitives and parameterized deformations which can capture the local shape variation of a complex object. Furthermore, these parameters are intuitive and require no complex post-processing in order to be used by a physician. Using a physics-based approach, the authors convert the geometric models into dynamic models that deform due to forces exerted from the datapoints and conform to the given dataset. The authors present experiments involving the extraction of the shape and motion of the LV's mid-wall during systole from tagged MRI data based on a few parameter functions. Furthermore, by plotting the variations over time of the extracted LV model parameters from normal and abnormal heart data along the long axis, the authors are able to quantitatively characterize their differences.