Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Workplace Spirituality and Organizational Citizenship Behavior on Nursing Performance

Purpose: The purpose of this study was to examine the effects of workplace spirituality and organizational citizenship behavior on nurses’ performance of nursing. Methods: This study was done over a 6 month period, with 395 nurses participants from 5 different general hospitals with 400 beds in 4 regions of Korea. Data were gathered using self-reported questionnaires from July 23 to August 21, 2015. Data were analyzed using descriptive statistics, independent t-test, one way ANOVA, Pearson correlation coefficients, and multiple regression analyses with IBM SPSS 21.0 program. Results: Nursing performance showed positive correlations with workplace spirituality and organizational citizenship behavior. The significant predictors of the nursing performance by nurses were a master's degree or higher (β=.26), civic virtue (β=.19), courtesy (β=.12), 40 years of age or older (β=.09), a sense of empathy (β=.07), and a bachelor's degree in nursing (β=.06). These variables explained 39.2% of the variance in nursing performance by nurses. Conclusion: Based on the outcomes of this study, there is a need to develop intervention programs that can inspire nurse to show spontaneous organizational citizenship behavior, and enhance their workplace spirituality. Related variables including academic credentials should also be taken into account.
The experience of having psoriasis through the lens of the International Classification of Functioning, Disability and Health (ICF)

The International Classification of Functioning, Disability and Health (ICF) was developed by the World Health Organization to comprehensively describe the ways that health conditions can affect people. The identification of ICF categories of most relevance to people with a particular disease can increase the usefulness of the ICF and create a reference for outcome studies. This study aimed to ascertain, through focus group interviews with psoriasis patients and an online Delphi survey with health professionals, the impacts of psoriasis as categorised by the ICF.
A Folded RF Front-end with Low Flicker Noise for Bluetooth and ZigBee application

This paper presents the designed and implemented RF front-end to reduce the flicker noise and power consumption in TSMC 0.18 mum process. The proposed RF front-end is composed of folded mixer and differential low noise amplifier (LNA). To minimize flicker noise, the proposed RF front-end is designed by using PMOS devices in switching stage of mixers with an resonating inductor. For low power consumption, transconductance stage and switching stage of mixers are designed with folded architecture, and LNA and transconductance stage of mixer are designed with current reused architecture for small current flow. The proposed RF front-end consumes 7.34 mW from 1.2 V supply voltage, while conversion gain of 23 dB is achieved. The IIP3 is -7.4 dBm, and the proposed RF front-end has good linearity. Flicker noise of 10 dB at 1 kHz is acceptable value, and thus proposed RF front-end can be used in direct conversion receiver for a narrow bandwidth.
A Novel Electrically Tunable RF Inductor With Ultra-Low Power Consumption

In this study, we propose for the first time an electrically and continuously tunable RF inductor using grounded metal oxide semiconductor (MOS) transistor as a control device. By adjusting the output resistance of the grounded MOSFET, the ground-return current can lead to a significant variation in series inductance. This proposed inductor structure was implemented in a standard CMOS process and characterized up to 30 GHz, which demonstrates maximum inductance variations of 32% and 58% at 5.8 and 18 GHz, respectively. The dc power consumption of the proposed design is kept within 50 muW over the entire tuning range.
20-GHz power combining slot-oscillator array

A four-element power-combining array of quasioptical slot oscillators has been constructed at 20 GHz. The array is placed on a dielectric substrate lens to increase the directivity and the effective isotropic radiated power (EIRP). The array delivers a total power output of 68 mW with an effective isotropic radiated power of 4.4 W. The DC to RF efficiency of the array is 12%. The substrate lens approach provides a planar design that eliminates substrate mode problems and, therefore, is easily scaled to millimeter-wave frequencies. <<ETX>>
Facile fabrication of an efficient BiVO4 thin film electrode for water splitting under visible light irradiation

An efficient BiVO4 thin film electrode for overall water splitting was prepared by dipping an F-doped SnO2 (FTO) substrate electrode in an aqueous nitric acid solution of Bi(NO3)3 and NH4VO3, and subsequently calcining it. X-ray diffraction of the BiVO4 thin film revealed that a photocatalytically active phase of scheelite-monoclinic BiVO4 was obtained. Scanning electron microscopy images showed that the surface of an FTO substrate was uniformly coated with the BiVO4 film with 300–400 nm of the thickness. The BiVO4 thin film electrode gave an excellent anodic photocurrent with 73% of an IPCE at 420 nm at 1.0 V vs. Ag/AgCl. Modification with CoO on the BiVO4 electrode improved the photoelectrochemical property. A photoelectrochemical cell consisting of the BiVO4 thin film electrode with and without CoO, and a Pt counter electrode was constructed for water splitting under visible light irradiation and simulated sunlight irradiation. Photocurrent due to water splitting to form H2 and O2 was confirmed with applying an external bias smaller than 1.23 V that is a theoretical voltage for electrolysis of water. Water splitting without applying external bias under visible light irradiation was demonstrated using a SrTiO3∶Rh photocathode and the BiVO4 photoanode.
American Genotype Structures Decrease Dengue Virus Output from Human Monocytes and Dendritic Cells

ABSTRACT The dengue virus type 2 structures probably involved in human virulence were previously defined by sequencing the complete genome of both American and Southeast (SE) Asian genotype templates in patient serum (K. C. Leitmeyer et al., J. Virol. 73:4738-4747, 1999). We have now evaluated the effects of introducing a mutation in the envelope glycoprotein (E) gene and/or replacement of 5′- and 3′-nontranslated regions on dengue virus replication in human primary cell cultures. A series of chimeric infectious clones were generated containing different combinations of American and SE Asian genotype sequences. Some of the chimeric viruses had altered plaque morphology in mammalian cells; however, they replicated at similar rates in mosquito cells as measured by quantitative reverse transcription-PCR and plaque assay. Although susceptibility to virus infection varied from donor to donor in experiments using human macrophage and dendritic cells, we were able to measure consistent differences in viral RNA output per infected cell. Using this measurement, we demonstrated that the chimeric virus containing the E mutation had a lower virus output compared to the parental infectious clone. A larger reduction in virus output was observed for the triple mutant and the wild-type, American genotype virus from which chimeric inserts were derived. It appears that the three changes function synergistically, although the E mutation alone gives a lower output compared to the 5′- and 3′-terminal mutations. The data suggest that these changes may be responsible for decreased dengue virus replication in human target cells and for virulence characteristics during infection.
Direct Transmit Antenna Selection for Transmit Optimized Spatial Modulation

To improve the performance of spatial modulation (SM) over correlated MIMO channels, transmit optimized spatial modulation (TOSM) has been proposed recently. It trades off traditional signal constellation diagrams with spatial constellation diagrams to minimize the average bit error probability (ABEP). After the optimum number of transmit antennas is determined, the specific antennas need to be carefully chosen from the entire array to provide a minimum ABEP. Like in conventional transmit antenna selection (TAS) schemes, the problem can be solved by an exhaustive search. However, this results in an unaffordable complexity especially when the spectral efficiency is high. In this paper, we propose a creative TAS approach for TOSM. Given a required number of antennas, the novel technique determines the selection solution based on circle packing. Simulation results show that for various channel correlations and spectral efficiencies, the proposed method achieves performance results close to exhaustive search with a gap of less than 0.3 dB. The complexity is reduced to an extremely low level.
Long‐term effects of specific immunotherapy, administered during childhood, in asthmatic patients allergic to either house‐dust mite or to both house‐dust mite and grass pollen

In a retrospective study, asthmatic patients allergic to either house‐dust mite (HDM) (Dermatophagoides pteronyssinus) (n=34) or to both HDM and grass pollen (GP) (n=14), and who were treated with specific immunotherapy (SIT) during childhood (mean duration of SIT: 61±9.70 months), were re‐evaluated in early adulthood after mean cessation of SIT for 9.3±2.76 years. The results were compared to those of a control group of asthmatic patients (n=42) with comparable asthma features, who were treated with appropriate antiasthmatic drugs during childhood, but who never received SIT. Re‐evaluation was carried out with a standardized questionnaire, skin prick tests (SPT), and lung‐function assessments. At the time of re‐evaluation, the mean age in the SIT‐treated group was 23.1±3.50 years; in the control group, it was 22.7±3.40 years. At re‐evaluation, the risk of frequent asthmatic symptoms was three times higher in the control group than in the SIT‐treated group (prevalence ratio: 3.43; P=0.0006). The frequent use of antiasthmatic medication was also more pronounced in the control group, although the difference was not statistically significant (P=0.38). Lung‐function parameters and results of SPT with HDM were comparable in both groups. It is concluded that SIT has long‐term effects on asthmatic symptoms in young adults.
Reference genes for quantitative RT-PCR data in gastric tissues and cell lines.

AIM To evaluate the suitability of reference genes in gastric tissue samples and cell lines. METHODS The suitability of genes ACTB, B2M, GAPDH, RPL29, and 18S rRNA was assessed in 21 matched pairs of neoplastic and adjacent non-neoplastic gastric tissues from patients with gastric adenocarcinoma, 27 normal gastric tissues from patients without cancer, and 4 cell lines using reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR). The ranking of the best single and combination of reference genes was determined by NormFinder, geNorm™, BestKeeper, and DataAssist™. In addition, GenEx software was used to determine the optimal number of reference genes. To validate the results, the mRNA expression of a target gene, DNMT1, was quantified using the different reference gene combinations suggested by the various software packages for normalization. RESULTS ACTB was the best reference gene for all gastric tissues, cell lines and all gastric tissues plus cell lines. GAPDH + B2M or ACTB + B2M was the best combination of reference genes for all the gastric tissues. On the other hand, ACTB + B2M was the best combination for all the cell lines tested and was also the best combination for analyses involving all the gastric tissues plus cell lines. According to the GenEx software, 2 or 3 genes were the optimal number of references genes for all the gastric tissues. The relative quantification of DNMT1 showed similar patterns when normalized by each combination of reference genes. The level of expression of DNMT1 in neoplastic, adjacent non-neoplastic and normal gastric tissues did not differ when these samples were normalized using GAPDH + B2M (P = 0.32), ACTB + B2M (P = 0.61), or GAPDH + B2M + ACTB (P = 0.44). CONCLUSION GAPDH + B2M or ACTB + B2M is the best combination of reference gene for all the gastric tissues, and ACTB + B2M is the best combination for the cell lines tested.
X-ray crystal structure of the soybean agglutinin cross-linked with a biantennary analog of the blood group I carbohydrate antigen.

Soybean agglutinin (SBA) (Glycine max), which is a tetrameric GalNAc/Gal-specific lectin, has recently been reported to form unique, highly organized cross-linked complexes with a series of naturally occurring and synthetic multiantennary carbohydrates with terminal GalNAc or Gal residues [Gupta, D. , Bhattacharyya, L. , Fant, J., Macaluso, F. , Sabesan, S. , & Brewer, C. F. (1994) Biochemistry 33, 7495-7504]. In order to elucidate the nature of these complexes, the X-ray crystallographic structure of SBA cross-linked with a biantennary analog of the blood group I carbohydrate antigen is reported. The structure reveals that lattice formation is promoted uniquely by the bridging action of the bivalent pentasaccharide (beta-LacNAc)2Gal-beta-R, where R is -O(CH2)5COOCH3 and the beta-LacNAc moieties are linked to the 2 and 6 positions of the core Gal. The structure of SBA complexed with the synthetic biantennary pentasaccharide has thus been determined by molecular replacement techniques and refined at 2.6 A resolution to an R value of 20.1%. The crystals are hexagonal with a P6(4)22 space group, which differs significantly from that of crystals of the free protein. In the structure, each monomeric asymmetric unit contains a Man9 oligomannose-type chain at Asn 75, with only the first two GlcNAc residues visible. The overall tertiary structure of the SBA subunit is similar to that of other legume lectins as well as certain animal lectins. However, the dimer interface in the SBA tetramer is unusual in that only one complete peptide chain is sterically permitted, thus requiring juxtapositioning of one C-terminal fragmented subunit together with an intact subunit. Association between SBA tetramers involves binding of the terminal Gal residues of the pentasaccharide at identical sites in each monomer, with the sugar cross-linking to a symmetry-related neighbor molecule. The cross-linking pentasaccharide is in a conformation that possesses a pseudo-2-fold axis of symmetry which lies on a crystallographic 2-fold axis of symmetry of the lattice. Hence, the symmetry properties of the bivalent oligosaccharide as well as the lectin are structural determinants of the lattice. The results are discussed in terms of multidimensional carbohydrate-lectin cross-linked complexes, as well as the signal transduction properties of multivalent lectins.
TCR signal initiation machinery is pre‐assembled and activated in a subset of membrane rafts

Recent studies suggest that rafts are involved in numerous cell functions, including membrane traffic and signaling. Here we demonstrate, using a polyoxyethylene ether Brij 98, that detergent‐insoluble microdomains possessing the expected biochemical characteristics of rafts are present in the cell membrane at 37°C. After extraction, these microdomains are visualized as membrane vesicles with a mean diameter of ∼70 nm. These findings provide further evidence for the existence of rafts under physiological conditions and are the basis of a new isolation method allowing more accurate analyses of raft structure. We found that main components of T cell receptor (TCR) signal initiation machinery, i.e. TCR–CD3 complex, Lck and ZAP‐70 kinases, and CD4 co‐receptor are constitutively partitioned into a subset of rafts. Functional studies in both intact cells and isolated rafts showed that upon ligation, TCR initiates the signaling in this specialized raft subset. Our data thus strongly indicate an important role of rafts in organizing TCR early signaling pathways within small membrane microdomains, both prior to and following receptor engagement, for efficient TCR signal initiation upon stimulation.
The Delirium Drug Scale is associated to delirium incidence in the emergency department

ABSTRACT Background: The Delirium Drug Scale (DDS) is an evaluation scale developed to assess a patient's drug burden for delirium. The primary goal is to validate the association between the DDS score and the incidence of delirium. Methods: This study was an observational retrospective cross-sectional chart review study in patients aged 75 years and older. It was carried out in three emergency departments of a tertiary care university health center. Patients were included if a medication list was available. Delirium present upon admission was assessed during the first five days of admission. Results: A total of 1,205 subjects were included in the analysis. The mean age was of 83.4 years, and 62.4% were female. The prevalence of delirium was 19.1%. A total of 745 patients (62%) were exposed to DDS medication. The relative risk for the low (1–2) and high (>2) exposure group according to the DDS score was of 1.26 (CI: 0.95; 1.66) and 2.18 (CI: 1.61; 2.96) compared to a score of 0. In the multivariate analysis, dementia, anxiety, insomnia, history of delirium, infection, and acute kidney failure were significantly associated to delirium. When adjusted for confounding variables, the DDS score was associated with the incidence of delirium with an odd ratio (OR) of 1.29 (CI: 1.16; 1.44). Conclusions: This study found that DDS score was associated with delirium incidence. The association persisted in the multivariate analysis adjusted for 26 known risks and precipitating factors for delirium.
Comparison of high frequency jet ventilation to conventional ventilation during severe acute respiratory failure in humans

High frequency jet ventilation (HFJV) was compared to conventional (high tidal volume, low frequency) ventilation in 9 patients with acute respiratory failure (ARF). Alveolar ventilation was comparable or lower with HFJV in all but one case. When comparisons were made at the same concentration of oxygen and level of PEEP, no consistent change in arterial oxygenation (Pao2) was found. In one case, it was possible to increase Pao2) during HFJV by additional increases in PEEP without elevation in peak airway pressure (AWP) compared to conventional ventilation (CV). At the same level of PEEP, peak AWP was lower during HFJV, except in 1 patient with bronchospasm. Cardiac output did not differ significantly between the 2 ventilation systems, except in the same patient with bronchospasm. HFJV may be useful in acute respiratory failure when peak AWP during CV limits effective use of mechanical ventilation for gas exchange. Patients with significantly elevated airway resistance may be an exception. Improvement in Pao2 will usually depend on increases in PEEP.
NEDD9 promotes lung cancer metastasis through epithelial–mesenchymal transition

Metastasis is the major cause for high mortality of lung cancer with the underlying mechanisms poorly understood. The scaffolding protein neural precursor cell expressed, developmentally down‐regulated 9 (NEDD9) has been identified as a pro‐metastasis gene in several types of cancers including melanoma and breast cancer. However, the exact role and related mechanism of NEDD9 in regulating lung cancer metastasis still remain largely unknown. Here, we demonstrate that NEDD9 knockdown significantly inhibits migration, invasion and metastasis of lung cancer cells in vitro and in vivo. The pro‐metastasis role of Nedd9 in lung cancer is further supported by studies in mice models of spontaneous cancer metastasis. Moreover, we find that NEDD9 promotes lung cancer cell migration and invasion through the induction of epithelial–mesenchymal transition (EMT) potentially via focal adhesion kinase activation. More importantly, NEDD9 expression inversely correlates with E‐cadherin expression in human lung cancer specimens, consistent with the findings from in vitro studies. Taken together, this study highlights that NEDD9 is an important mediator promotes lung cancer metastasis via EMT.
The Survival Benefit of Liver Transplantation

Demand for liver transplantation continues to exceed donor organ supply. Comparing recipient survival to that of comparable candidates without a transplant can improve understanding of transplant survival benefit. Waiting list and post‐transplant mortality was studied among a cohort of 12 996 adult patients placed on the waiting list between 2001 and 2003. Time‐dependent Cox regression models were fitted to determine relative mortality rates for candidates and recipients. Overall, deceased donor transplant recipients had a 79% lower mortality risk than candidates (HR = 0.21; p < 0.001). At Model for End‐stage Liver Disease (MELD) 18–20, mortality risk was 38% lower (p < 0.01) among recipients compared to candidates. Survival benefit increased with increasing MELD score; at the maximum score of 40, recipient mortality risk was 96% lower than that for candidates (p < 0.001). In contrast, at lower MELD scores, recipient mortality risk during the first post‐transplant year was much higher than for candidates (HR = 3.64 at MELD 6–11, HR = 2.35 at MELD 12–14; both p < 0.001). Liver transplant survival benefit at 1 year is concentrated among patients at higher risk of pre‐transplant death. Futile transplants among severely ill patients are not identified under current practice. With 1 year post‐transplant follow‐up, patients at lower risk of pre‐transplant death do not have a demonstrable survival benefit from liver transplant.
Issues in confocal microscopy for quantitative FRET analysis

Previously, we have carried out extensive quantitative analysis of Förster (or fluorescence) resonance energy transfer (FRET) data to show that polymeric IgA receptors and their ligands cluster in endocytic membranes in the process of sorting and trafficking in polarized cells. Here, we use a similar technique to assay the organization and distribution of another membrane‐bound receptor: transferrin receptor (TFR) and its ligand, holo‐transferrin (Tfn), while explaining the step‐by‐step measures to be taken for successful quantitative analysis of the FRET data. In particular, methodological issues in FRET quantitative imaging, such as spectral bleed‐through and background correction, optimal selection of regions of interest, how to deal with outliers and pooling data and statistical analysis of FRET data, are addressed. Our results indicating a clustered organization of TFR–Tfn complexes fit the well‐known homodimeric structure of TFR. These quantitative approaches can be adapted for other biological applications of FRET. Microsc. Res. Tech. 69:196–206, 2006. © 2006 Wiley‐Liss, Inc.
Preconditioning of linear least squares by RIF for implicitly held normal equations

The efficient solution of the normal equations corresponding to a large sparse linear least squares problem can be extremely challenging. Robust incomplete factorization (RIF) preconditioners represent one approach that has the important feature of computing an incomplete LLT factorization of the normal equations matrix without having to form the normal matrix itself. The right-looking implementation of Benzi and Tůma has been used in a number of studies but experience has shown that in some cases it can be computationally slow and its memory requirements are not known a priori. Here a new left-looking variant is presented that employs a symbolic preprocessing step to replace the potentially expensive searching through entries of the normal matrix. This involves a directed acyclic graph (DAG) that is computed as the computation proceeds. An inexpensive but effective pruning algorithm is proposed to limit the number of edges in the DAG. Problems arising from practical applications are used to compare the performance of the right-looking approach with a left-looking implementation that computes the normal matrix explicitly and our new implicit DAG-based left-looking variant.