Miracle-dz/UniFAR-FTUs huggingface dataset:
SRPK1 Dissimilarly Impacts on the Growth, Metastasis, Chemosensitivity and Angiogenesis of Glioma in Normoxic and Hypoxic Conditions

Glioma is among the ten most common causes of cancer-related death and has no effective treatment for it, so we are trying to find a new target for anticancer treatment. This study investigates the different expression of SRPK1 as a novel protein in glioma, which can influence tumor cells biological characteristics in normoxic and hypoxic environment. The expression levels of SRPK1 protein in glioma cell lines transfected with siSRPK1 or not were examined using immunofluorescence, RT-PCR and Western blot analysis, respectively. The impact of SRPK1 on the biological characteristics of U251 cells was further studied using methylthiazol tetrazolium assays, flow cytometry, and Transwell invasion chamber assays. The results showed that knockdown of SRPK1 inhibited tumor cells growth, invasion and migration in normoxic condition, but portion of the effect could be reversed in hypoxia. SRPK1 expression was induced in glioma cells by DDP treated, but not TMZ, in both normoxia and hypoxia conditions. We propose SRPK1 as a new molecular player contributing to the early treatment of glioma.
The Impact of Coping Flexibility on the Risk of Depressive Symptoms

Objective According to the dual-process theory, coping flexibility is defined as the ability to produce and implement a new coping strategy in place of an ineffective coping strategy. Specifically, coping flexibility includes two processes: evaluation coping and adaptive coping. Evaluation coping refers to sensitivity to feedback about the efficacy of a coping strategy, and adaptive coping involves the willingness to implement alternative coping strategies. The coping flexibility hypothesis (CFH) postulates that more flexible coping will be associated with more adaptive outcomes; importantly, there are numerous theories and studies that support the CFH. The main purpose of this study was to test the CFH based on dual-process theory. Methods A total of 1,770 Japanese college students participated and, completed a set of questionnaires that measured coping flexibility (evaluation coping and adaptive coping) and depressive symptoms. Depressive symptoms were measured via the Center for Epidemiologic Studies Depression Scale. Results The proportions of women and men who reported depressive symptoms were 58.69% (95% CIs [55.74, 61.66]) and 54.17% (95% CIs [50.37, 57.95]), respectively when a cut-off score of 16 on the CES-D was used. A multivariable logistic regression analysis revealed that evaluation coping (OR = 0.86, 95% CIs [0.83, 0.0.89]) and adaptive coping (OR = 0.91, 95% CIs [0.88, 0.93]) were significantly associated with lower levels of depressive symptoms. Conclusion The results of the present study indicated that the CFH based on dual-process theory was supported in a Japanese sample.
Dynamic IQ data compression using wireless resource allocation for mobile front-haul with TDM-PON [invited]

The time-division multiplexed-passive optical network (TDM-PON) architecture can efficiently accommodate densely deployed small cells in a centralized radio access network (C-RAN)-based future radio access (FRA). C-RAN is a type of mobile front-haul network, which connects multiple remote radio heads to a baseband unit pool by optical links. The required optical bandwidth in the mobile front-haul of FRA is very large, so it is necessary to efficiently use the optical bandwidth by using in-phase and quadrature-phase (IQ) data compression techniques. This paper proposes an IQ data compression technique that dynamically reduces the required optical bandwidth based on wireless resource allocation, and provides TDM-PON with statistical multiplexing gain. Simulation results showed the achievable compression ratio of the proposed IQ data compression technique. The feasibility of our technique was confirmed by experiments. The reduction in the average TDM-PON bandwidth was 50% when there were 60 mobile terminals, all of which required 0.18 Mbps bandwidth.
Trademarks recognition based on local regions similarities

This paper deals with content based image retrieval. We propose a logo recognition algorithm based on local regions, where the trademark (or logo) image is segmented by the clustering of points of interest obtained by Harris corners detector. The minimum rectangle surrounding each cluster is detected forming the regions of interest. Global features such as Hu moments and histograms of each local region are combined to find similar logos in the database. Similarity is measured based on the integrated minimum average distance of the individual components. The results obtained demonstrate tolerance to logos distortions such as rotation, occlusion and noise.
Helping Users Create Better Passwords

blase Ur is a second-year Phd student in the School of computer Science at carnegie mellon University. His research focuses on usable security and privacy, including passwords, online behavioral advertising, and privacy decision making. He received his undergraduate degree in computer science from Harvard University. mexico. His research centers on information design, usability, and education around privacy. He recently completed his thesis at carnegie mellon University on standardized, user-friendly privacy displays for privacy policies and Android permission Saranga Komanduri is a Phd student in the School of computer Science at carnegie mellon University. His research covers a broad spectrum of security-related Over the past several years, we have researched how passwords are created, how they resist cracking, and how usable they are. In this article, we focus on recent work in which we tested various techniques that may encourage better password choices. What we found may surprise you. Despite a litany of proposed password replacements, text-based passwords are not going to disappear anytime soon [4]. Passwords have a number of advantages over other authentication mechanisms. They are simple to implement, relatively straightforward to revoke or change, easy for users to understand, and allow for quick authentication; however, passwords also have a number of drawbacks. Foremost among these drawbacks is that it is difficult for users to create and remember passwords that are hard for an attacker to guess. Our research group at Carnegie Mellon University has been investigating strategies to guide users to create passwords that are both secure and memorable. In particular, we have focused on techniques such as password-composition policies and password-strength meters—two of the most ubiquitous strategies employed by system administrators to help users create secure passwords. Although these strategies are commonly used, their effects had not been well understood. Through a series of online studies, we have aimed to understand how password-composition policies and meters affect password security, memorability, and user sentiment. The first step in evaluating the security of a password is to understand the threat model. For instance, one can argue that a password that is hard to guess within the first three or five tries is secure, since an attacker would quickly be locked out. All but the most obvious passwords tend to resist this type of online attack. Passwords have been under attack in other ways due to a spate of password-database compromises in recent years, including at sites like Gawker and …
Blur filtration fails to preserve privacy for home-based video conferencing

Always-on video provides rich awareness for distance-separated coworkers. Yet video can threaten privacy, especially when it captures telecommuters working at home. We evaluated video blurring, an image masking method long touted to balance privacy and awareness. Results show that video blurring is unable to balance privacy with awareness for risky situations. Reactions by participants suggest that other popular image masking techniques will be problematic as well. The design implication is that image masking techniques will not suffice for privacy protection in video-based telecommuting situations. Other context-aware privacy-protecting strategies are required, as illustrated in our prototype context-aware home media space.
DEVELOPMENT OF ARTIFICIAL LATERAL-LINE FLOW SENSORS

SUMMARY We report the development of an underwater flow sensor that is based on biological inspiration – the biological lateral line sensors. The design, fabrication process and initial testing results for an artificial lateral line sensor are reported. The fabrication is based on a highly efficiently three-dimensional assembly process, used in conjunction with silicon micromachining techniques.
Scientific OLAP for the Biotech Domain

On-line analysis of clinical study data has not benefited from recent advances in OLAP technologies. We examine the analysis requirements posed by the biotech domain that are not met by traditional OLAP. To accommodate these new requirements, we propose the concept of Scientific OLAP which applies more broadly to data analysis in controlled scientific experiments. We describe our experience implementing such a system for the support of biomarker discovery and we identify some key challenges that must be overcome before OLAP can be widely adopted in the biotech industry.
Cooperative positioning with multiple robots

A number of positioning identification techniques have been used for mobile robots. Dead reckoning is a popular method, but is not reliable when a robot travels long distances or over an uneven surface because of variations in wheel diameter and wheel slippage. The landmark method, which estimates the current position relative to landmarks, cannot be used in an uncharted environment. The authors propose a new method called "cooperative positioning with multiple robots". For cooperative positioning, the authors divide the robots into two groups, A and B. One group, say A, remains stationary and acts as a landmark while group B moves. The moving group B then stops and acts as a landmark for group A. This "dance" is repeated until the target robot position are reached. Cooperative positioning has a far lower accumulated positioning error than dead reckoning, and can work in three-dimensions which is not possible with dead reckoning. Also, this method has inherent landmarks and therefore works in uncharted environments. This paper discusses the positioning accuracy of the authors' method with error variances for an example with three mobile robots. <<ETX>>
Transmission of Escherichia coli O157:H7 in cattle is influenced by the level of environmental contamination

SUMMARY A pen infection-transmission experiment was conducted to elucidate the role of pathogen strain and environmental contamination in transmission of Escherichia coli O157:H7 (ECO157) in cattle. Five steers were inoculated with a three-strain mixture of ECO157 and joined with five susceptible steers in each of two experimental replicates. Faecal and environmental samples were monitored for ECO157 presence over 30 days. One ECO157 strain did not spread. Transmission rates for the other two strains were estimated using a generalized linear model developed based on a modified ‘Susceptible–Infectious–Susceptible’ mathematical model. Transmission rates estimated for the two strains (0·11 and 0·14) were similar. However, the rates significantly (P = 0·0006) increased 1·5 times for every 1-unit increase in the level of environmental contamination measured as log10 c.f. u. Depending on the level of environmental contamination, the estimated basic reproduction numbers varied from <1 to 8. The findings indicate the importance of on-farm measures to reduce environmental contamination for ECO157 control in cattle that should be validated under field conditions.
The MAFT Architecture for Distributed Fault Tolerance

A description is given of the multicomputer architecture for fault tolerance (MAFT), a distributed system designed to provide extremely reliable computation in real-time control systems. MAFT is based on the physical and functional partitioning of executive functions from applications functions. The implementation of the executive functions in a special-purpose hardware processor allows the fault-tolerance functions to be transparent to the application programs and minimizes overhead. Byzantine agreement and approximate agreement algorithms are used for critical system parameters. MAFT supports the use of multiversion hardware and software to tolerate built-in or generic faults. Graceful degradation and restoration of the application workload is permitted in response to the exclusion and readmission of nodes, respectively. >
Please Scroll down for Article Journal of New Music Research Improving Music Genre Classification Using Automatically Induced Harmony Rules Improving Music Genre Classification Using Automatically Induced Harmony Rules

This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, redistribution , reselling , loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. Abstract We present a new genre classification framework using both low-level signal-based features and high-level harmony features. A state-of-the-art statistical genre classifier based on timbral features is extended using a first-order random forest containing for each genre rules derived from harmony or chord sequences. This random forest has been automatically induced, using the first-order logic induction algorithm TILDE, from a dataset, in which for each chord the degree and chord category are identified, and covering classical, jazz and pop genre classes. The audio descriptor-based genre classifier contains 206 features, covering spectral, temporal, energy, and pitch characteristics of the audio signal. The fusion of the harmony-based classifier with the extracted feature vectors is tested on three-genre subsets of the GTZAN and ISMIR04 datasets, which contain 300 and 448 recordings, respectively. Machine learning classifiers were tested using 5 6 5-fold cross-validation and feature selection. Results indicate that the proposed harmony-based rules combined with the timbral descriptor-based genre classification system lead to improved genre classification rates.
Decon and interpolation with nonstationary lters

Building on the notions of time-variable ltering and the helix coordinate system, we develop software for lters that are smoothly variable in multiple dimensions. Multiscale prediction-error lters (PEFs) can estimate dips from recorded data and use the dip information to ll in unrecorded shot or receiver gathers. The data are typically divided into patches with approximately constant dips. Instead, we estimate a set of smoothly varying lters, up to one PEF for every data sample. They are more memory-intensive to estimate, but the smoothly varying lters do give more accurate interpolation results than discrete patches. Finally, we oer an improved method of controlling the smoothness of the lters. We design lters like directional derivatives that we call \ag lters". They destroy dips in easily adjusted directions. We use them in residual space to encourage dips in the specied directions. We develop the notion of \radial-ag lters", i.e., ag lters oriented in the radial direction (lines of constant x=t in (t;x) space). Break a common-midpoint gather into pie shaped regions bounded by various values of x=t. Such a pie-shaped region tends to have constant dip spectrum throughout the region so it is a natural region for smoothing estimates of dip spectra or of gathering statistics (via 2-D PEFs). In this paper we use smoothly variable PEFs to interpolate missing traces, though obviously they have many other uses.
Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted lung architecture and loss of respiratory function. Alveolar epithelial cell injury and hyperplasia, enhanced extracellular matrix deposition, and (myo)fibroblast activation are features of IPF. Wnt/β-catenin signaling has been shown to determine epithelial cell fate during development. As aberrant reactivation of developmental signaling pathways has been suggested to contribute to IPF pathogenesis, we hypothesized that Wnt/β-catenin signaling is activated in epithelial cells in IPF. Thus, we quantified and localized the expression and activity of the Wnt/β-catenin pathway in IPF. Methodology/Principal Findings The expression of Wnt1, 3a, 7b, and 10b, the Wnt receptors Fzd1-4, Lrp5-6, as well as the intracellular signal transducers Gsk-3β, β-catenin, Tcf1, 3, 4, and Lef1 was analyzed in IPF and transplant donor lungs by quantitative real-time (q)RT-PCR. Wnt1, 7b and 10b, Fzd2 and 3, β-catenin, and Lef1 expression was significantly increased in IPF. Immunohistochemical analysis localized Wnt1, Wnt3a, β-catenin, and Gsk-3β expression largely to alveolar and bronchial epithelium. This was confirmed by qRT-PCR of primary alveolar epithelial type II (ATII) cells, demonstrating a significant increase of Wnt signaling in ATII cells derived from IPF patients. In addition, Western blot analysis of phospho-Gsk-3β, phospho-Lrp6, and β-catenin, and qRT-PCR of the Wnt target genes cyclin D1, Mmp 7, or Fibronectin 1 demonstrated increased functional Wnt/β-catenin signaling in IPF compared with controls. Functional in vitro studies further revealed that Wnt ligands induced lung epithelial cell proliferation and (myo)fibroblast activation and collagen synthesis. Conclusions/Significance Our study demonstrates that the Wnt/β-catenin pathway is expressed and operative in adult lung epithelium. Increased Wnt/β-catenin signaling may be involved in epithelial cell injury and hyperplasia, as well as impaired epithelial-mesenchymal cross-talk in IPF. Thus, modification of Wnt signaling may represent a therapeutic option in IPF.
Activity Based Costing : Success is in the Eye of the Beholder

The literature on Activity Based Costing (ABC) tends to define the ‘success’ of an ABC system in relation to the decision-making and strategy formulating opportunities it provides based on the ‘logic’ or technical attributes of ABC (Shields, 1995; Malmi, 1997). This paper argues that there is a logic of ABC and tries to identify and illustrate how people relate to, misunderstand and still ‘appropriate’ this logic and start “talking accounting”. This paper shows that the ABC system implemented in this organisation did indeed provide information for decision-making and did to some extent support the logic of ABC. The paper also shows how this knowledge was emergent, the logic was articulated, but not fully understood and it was only when the system was implemented that many attributes of the system were recognised and, in some cases misunderstood. The paper argues that the ‘success’ of this particular ABC system was dependent on the organisational context, and the changing context as well as the logic. This is reflected in the change in attitudes, awareness and understanding of costs in the department where it was implemented.
ON THE NUMBER OF ELLIPTIC CURVES WITH PRESCRIBED ISOGENY OR TORSION GROUP OVER NUMBER FIELDS OF PRIME DEGREE

Abstract Let p be a prime and K a number field of degree p. We determine the finiteness of the number of elliptic curves, up to K-isomorphism, having a prescribed property, where this property is either that the curve contains a fixed torsion group as a subgroup or that it has a cyclic isogeny of prescribed degree.
MANY FACES OF INNOVATION : From literature synthesis to empirical studies

The Open Innovation Banking System (OIBS) is a new generation environment for innovation in higher education. The technical implementation of the environment as a web based application is in progress as a joint effort of the OIBS community formed by the participating higher education institutions. After the initial release of the core application by the development team, anyone can join the community as a developer. The development key persons will concentrate on distributing the development and maintaining the community, and the community will be actively involved in entirely distributed development of the OIBS environment.
FLOW OVER A GIVEN PROFILE IN A CHANNEL WITH

The work deals with a numerical solution of steady and unsteady 2D inviscid in- compressible o w over the prole NACA 0012 in a channel. The o w is described by the system of Euler equations. Cell-centered nite-v olume scheme at quadrilateral C-mesh is used. Steady state solutions and also unsteady o ws caused by the prescribed oscillation of the prole were computed. The method of articial compressibility and the time dependent method are used for computation of the steady state solution. Some presented numerical results are compared with experimental data. a2 ; 1; 1 , a 2 R (method of articial compressibility). Here is the density (constant), p is the pressure and (u; v) is the velocity vector. Upstream conditions are u = u1; v = v1, p is extrapolated. Downstream con- dition is only given by p = p2. Next values of W2 are extrapolated. Wall conditions on xed walls of the channel are non-permeability conditions (u; v)n = 0 (normal component of velocity vector is equal to zero). Two approaches were applied to the wall conditions on the oscillating prole in the channel. Firstly the non-permeability conditions were applied, secondly the velocity vector of the o w eld near the prole
Acculturative Stress of Chinese Rural-To-Urban Migrant Workers: A Qualitative Study

Background Global literature has suggested a negative impact of acculturative stress on both physical and mental health among international migrants. In China, approximately 20 percent of its population is rural-to-urban migrant workers and there are significant cultural differences between rural and urban societies, but no data are available regarding the acculturative stress of Chinese migrant workers. This study aimed to explore the forms and contexts of acculturative stress among Chinese migrant workers. Methods Qualitative data were collected from four focus group discussions with 17 Chinese rural-to-urban migrant workers and three individual interviews with three medical professionals who provided mental health services for factory-workers in Shenzhen, China. Results The data in the current study showed that rural-to-urban migrant workers in China had experienced various forms of acculturative stress including difficulties in adapting to the environment, work-related stress, family-related stress, financial hardship, and lack of sense of belonging to cities. Conclusion Rural-to-urban migration in China is a challenging transition with significant acculturative stress and demands for major adjustments among migrant workers. The assessment and management of acculturative stress is a necessary first step in providing mental health services to migrant workers.