Miracle-dz/UniFAR-FTUs huggingface dataset:
Sensitive gazetteer discovery and protection for mobile social media users

With the explosive growth of location-aware devices and global adoption of social network applications, enormous volumes of spatiotemporal data are being produced. These can be perceived as gazetteers that record frequently visited locations, e.g. shopping malls and museums, and potentially more sensitive locations, e.g. an individual's home/work locations. Density-based clustering approaches are generally used for gazetteer discovery. However, existing clustering solutions are inefficient for big data scenarios and often disregard mobility features derived from trajectories data. Further, automated gazetteer discovery applications may cause privacy concerns. In this paper, we propose a sensitive gazetteer automated discovery approach based on Ω-cluster with robust privacy controls. The approach identifies sensitive gazetteers from massive trajectory data, with location entropy-based filtering used to reduce the number of uninteresting clusters whilst considering mobility features of trajectories. A parallelized solution is implemented to scale across the cloud using memory-oriented data processing solutions based upon Apache Spark. We embed this algorithm in a privacy-preserving mechanism and subsequently release sanitized gazetteers. Through extensive experiments using synthetic and real trajectory datasets from the location based social network (Twitter), we demonstrate the effectiveness and efficiency of our approach.
Embolization of cerebral arteriovenous malformations with n-butyl-2-cyanoacrylate.

PURPOSE To determine the safety and effectiveness of arteriovenous malformation (AVM) embolization using liquid adhesives in a series of 103 patients with cerebral AVMs who underwent embolization with n-butyl-2-cyanoacrylate (NBCA). METHODS All embolization procedures were performed using NBCA and a lipiodol mixture delivered by a flow-directed and/or guide-wire directed microcatheter. RESULTS Using the Spetzler-Martin grading system, there were two cases of grade I AVM, 23 of grade II AVM, 31 of grade III AVM, 37 of grade IV AVM, and 10 of grade V AVM. Eleven patients underwent embolization only; these patients either had evidence of morphologic cure on follow-up angiogram, or showed evidence of a stable condition at 2-years follow-up. Seven patients were not treated owing to technical problems or a positive functional test. All other patients underwent preoperative embolization; 75%-99% obliteration was noted in 39 of these patients, 50%-74% obliteration in 33, and less than 50% obliteration in 13. Embolization-related complications occurred in nine patients, and two patients died as a result of the procedure. Severe neurologic complications occurred in two patients and five patients developed mild or transient neurologic deficit. CONCLUSIONS Endovascular treatment of brain AVMs with an NBCA mixture has a lower complication rate than shown in previous studies using other materials. The percentage of obliteration of the nidus is increased because NBCA penetrates AVMs better than polyvinyl alcohol particles. NBCA can be used at a lower concentration than other acrylates, and therefore causes almost no catheter gluing. The embolic mass formed by NBCA is more biocompatable than that formed by other acrylates.
Growth differentiation factor-15 for prognostic assessment of patients with acute pulmonary embolism.

RATIONALE Growth differentiation factor (GDF)-15 is a cytokine induced in the heart after ischemia or pressure overload. Circulating levels of GDF-15 provide independent prognostic information in patients with acute coronary syndromes or heart failure. OBJECTIVES We investigated the prognostic value of GDF-15 in acute pulmonary embolism. METHODS In a prospective cohort study, plasma levels of GDF-15 were determined by immunoradiometric assay in 123 consecutive patients with confirmed acute pulmonary embolism. MEASUREMENTS AND MAIN RESULTS GDF-15 concentrations on admission ranged from 553 to 47,274 ng/L; 101 patients (82%) had GDF-15 levels above the upper limit of normal (1,200 ng/L). Patients who experienced pulmonary embolism-related complications during the first 30 days had higher baseline levels of GDF-15 (median, 6,039 [25th to 75th percentiles, 2,778 to 19,772] ng/L) compared with those with an uncomplicated course (median, 2,036 [25th to 75th percentiles, 1,279 to 3,176] ng/L; P < 0.001). By multivariable logistic regression analysis, which included clinical characteristics, cardiac biomarkers (troponin T and NT-proBNP [N-terminal propeptide of B-type natriuretic peptide]), and echocardiographic findings, GDF-15 emerged as an independent predictor of a complicated 30-day outcome (P = 0.033). The c-statistic for GDF-15 was 0.84 (95% confidence interval, 0.76-0.90), as compared with 0.72 for cardiac troponin T, and 0.65 for NT-proBNP. The ability of troponin T, NT-proBNP, and echocardiographic findings of right ventricular dysfunction to predict the risk of a complicated 30-day outcome was enhanced by GDF-15. Furthermore, multivariable Cox regression identified baseline levels of GDF-15 as an independent predictor of long-term mortality (P < 0.001). CONCLUSIONS GDF-15 is a promising new biomarker for risk stratification of pulmonary embolism.
Counteracting differential power analysis: Hiding encrypted data from circuit cells

We propose a balanced Pre-Charge Static Logic (PCSL) circuit style for asynchronous systems, and compare it against other reported circuit styles to counteract differential power analysis (DPA). Our study shows that all these circuit styles (including our balanced PCSL) dissipate different energy due to data-dependency, and hence balancing the energy of circuits embodying these circuit styles remains challenging. However, in view of low circuit overheads and asynchronous operations (with noise generation), our balanced PCSL is still competitive in terms of DPA-resistance, requiring 3.5x less power traces than its NULL convention logic counterpart.
Molecular Pharmacodynamics, Clinical Therapeutics, and Pharmacokinetics of Topiramate

Topiramate (TPM; TOPAMAX®) is a broad‐spectrum antiepileptic drug (AED) that is approved in many world markets for preventing or reducing the frequency of epileptic seizures (as monotherapy or adjunctive therapy), and for the prophylaxis of migraine. TPM, a sulfamate derivative of the naturally occurring sugar D‐fructose, possesses several pharmacodynamic properties that may contribute to its clinically useful attributes, and to its observed adverse effects. The sulfamate moiety is essential, but not sufficient, for its pharmacodynamic properties. In this review, we discuss the known pharmacodynamic and pharmacokinetic properties of TPM, as well as its various clinically beneficial and adverse effects.
Simple effective Zhang-dynamics stabilization control of the 4th-order hyper-chaotic Lu system with one input

This paper aims at achieving the stabilization control of hyper-chaotic Lu system with only one control input. By employing Zhang dynamics (ZD) method, which is a simple and effective method for designing control input, the expression of the desired controller is thus obtained. This easy-to-design controller, synthesized by following specific steps of ZD design method, is able to stabilize the 4th-order hyper-chaotic Lu system to the zero equilibrium steadily. Simple engineering-type theoretical analysis is given. In addition, simulations are conducted to testify the efficacy of the presented ZD controller in stabilizing the hyper-chaotic Lu system.
Physical Education and School Contextual Factors Relating to Students' Achievement and Cross-Grade Differences in Aerobic Fitness and Obesity

Using two major data sets from the Texas Youth Fitness Study, ordinary least squares regression, and hierarchical linear modeling, we examined the impact of key correlates in school physical education programs and policies on students' fitness status and crossgrade differences. While a number of factors, such as teachers' training/updates, recess time, available physical activity space, a school wellness policy, and fitness testing before administration, were confirmed, these correlates can explain only limited variance. Other aspects, such as socioeconomic status and community confounding factors, were recognized and illustrated. Future studies should include more factors such as these in data collection and analysis.
Overexpression of Zinc‐Finger Protein 777 (ZNF777) Inhibits Proliferation at Low Cell Density Through Down‐Regulation of FAM129A

Krüppel‐associated box‐containing zinc finger proteins (KRAB‐ZFPs) regulate a wide range of cellular processes. KRAB‐ZFPs have a KRAB domain, which binds to transcriptional corepressors, and a zinc finger domain, which binds to DNA to activate or repress gene transcription. Here, we characterize ZNF777, a member of KRAB‐ZFPs. We show that ZNF777 localizes to the nucleus and inducible overexpression of ZNF777 inhibits cell proliferation in a manner dependent on its zinc finger domain but independent of its KRAB domain. Intriguingly, ZNF777 overexpression drastically inhibits cell proliferation at low cell density but slightly inhibits cell proliferation at high cell density. Furthermore, ZNF777 overexpression decreases the mRNA level of FAM129A irrespective of cell density. Importantly, the protein level of FAM129A strongly decreases at low cell density, but at high cell density the protein level of FAM129A does not decrease to that observed at low cell density. ZNF777‐mediated inhibition of cell proliferation is attenuated by overexpression of FAM129A at low cell density. Furthermore, ZNF777‐mediated down‐regulation of FAM129A induces moderate levels of the cyclin‐dependent kinase inhibitor p21. These results suggest that ZNF777 overexpression inhibits cell proliferation at low cell density and that p21 induction by ZNF777‐mediated down‐regulation of FAM129A plays a role in inhibition of cell proliferation. J. Cell. Biochem. 116: 954–968, 2015. © 2015 Wiley Periodicals, Inc.
Streptomyces colonosanans sp. nov., A Novel Actinobacterium Isolated from Malaysia Mangrove Soil Exhibiting Antioxidative Activity and Cytotoxic Potential against Human Colon Cancer Cell Lines

Streptomyces colonosanans MUSC 93JT, a novel strain isolated from mangrove forest soil located at Sarawak, Malaysia. The bacterium was noted to be Gram-positive and to form light yellow aerial and vivid yellow substrate mycelium on ISP 2 agar. The polyphasic approach was used to determine the taxonomy of strain MUSC 93JT and the strain showed a range of phylogenetic and chemotaxonomic properties consistent with those of the members of the genus Streptomyces. Phylogenetic and 16S rRNA gene sequence analysis indicated that closely related strains include Streptomyces malachitofuscus NBRC 13059T (99.2% sequence similarity), Streptomyces misionensis NBRC 13063T (99.1%), and Streptomyces phaeoluteichromatogenes NRRL 5799T (99.1%). The DNA–DNA relatedness values between MUSC 93JT and closely related type strains ranged from 14.4 ± 0.1 to 46.2 ± 0.4%. The comparison of BOX-PCR fingerprints indicated MUSC 93JT exhibits a unique DNA profile. The genome of MUSC 93JT consists of 7,015,076 bp. The DNA G + C content was determined to be 69.90 mol%. The extract of strain MUSC 93JT was demonstrated to exhibit potent antioxidant activity via ABTS, metal chelating, and SOD assays. This extract also exhibited anticancer activity against human colon cancer cell lines without significant cytotoxic effect against human normal colon cells. Furthermore, the chemical analysis of the extract further emphasizes the strain is producing chemo-preventive related metabolites. Based on this polyphasic study of MUSC 93JT, it is concluded that this strain represents a novel species, for which the name Streptomyces colonosanans sp. nov. is proposed. The type strain is MUSC 93JT (= DSM 102042T = MCCC 1K02298T).
Feedforward ankle strategy of balance during quiet stance in adults

1 We studied quiet stance investigating strategies for maintaining balance. Normal subjects stood with natural stance and with feet together, with eyes open or closed. Kinematic, kinetic and EMG data were evaluated and cross‐correlated. 2 Cross‐correlation analysis revealed a high, positive, zero‐phased correlation between anteroposterior motions of the centre of gravity (COG) and centre of pressure (COP), head and COG, and between linear motions of the shoulder and knee in both sagittal and frontal planes. There was a moderate, negative, zero‐phased correlation between the anteroposterior motion of COP and ankle angular motion. 3 Narrow stance width increased ankle angular motion, hip angular motion, mediolateral sway of the COG, and the correlation between linear motions of the shoulder and knee in the frontal plane. Correlations between COG and COP and linear motions of the shoulder and knee in the sagittal plane were decreased. The correlation between the hip angular sway in the sagittal and frontal planes was dependent on interaction between support and vision. 4 Low, significant positive correlations with time lags of the maximum of cross‐correlation of 250‐300 ms were found between the EMG activity of the lateral gastrocnemius muscle and anteroposterior motions of the COG and COP during normal stance. Narrow stance width decreased both correlations whereas absence of vision increased the correlation with COP. 5 Ankle mechanisms dominate during normal stance especially in the sagittal plane. Narrow stance width decreased the role of the ankle and increased the role of hip mechanisms in the sagittal plane, while in the frontal plane both increased. 6 The modulation pattern of the lateral gastrocnemius muscle suggests a central program of control of the ankle joint stiffness working to predict the loading pattern.
New Potentiometric and Spectrophotometric Methods for the Determination of Dextromethorphan in Pharmaceutical Preparations

New, simple and convenient potentiometric and spectrophotometric methods are described for the determination of dextromethorphan hydrobromide (DXM) in pharmaceutical preparations. The potentiometric technique is based on developing a potentiometric sensor incorporating the dextromethorphan tetrakis( p -chlorophenyl)borate ion-pair complex as an electroactive species in a plasticized PVC matrix membrane with o -nitophenyl octyl ether or dioctyl phthalate. The sensor shows a rapid near Nernstian response of over 1 × 10^−5 - 1 × 10^−2 mol L^−1 dextromethorphan in the pH range of 3.0 - 9.0. The detection limit is 2 × 10^−6 mol L^−1 DXM and the response time is instantaneous (2 s). The proposed spectrophotometric technique involves the reaction of DXM with eriochrom black T (EBT) to form an ion-associate complex. Solvent extraction is used to improve the selectivity of the method. The optimal extraction and reaction conditions have been studied, and the analytical characteristics of the method have been obtained. Linearity is obeyed in the range of 7.37 - 73.7 × 10^−5 mol L^−1 DXM, and the detection limit of the method is 1.29 × 10^−5 mol L^−1. The relative standard deviation (RSD) and relative error for six replicate measurements of 3.685 × 10^−4 mol L^−1 are 0.672 and 0.855%, respectively. The interference effect of some excepients has also been tested. The drug contents in pharmaceutical preparations were successfully determined by the proposed methods by applying the standard-addition technique.
Rethinking the Educator Portfolio: An Innovative Criteria-Based Model.

PROBLEM Academic medical centers struggle to achieve parity in advancement and promotions between educators and discovery-oriented researchers in part because of narrow definitions of scholarship, lack of clear criteria for measuring excellence, and barriers to making educational contributions available for peer review. Despite recent progress in expanding scholarship definitions and identifying excellence criteria, these advances are not integrated into educator portfolio (EP) templates or curriculum vitae platforms. APPROACH From 2013 to 2015, a working group from the Academy of Medical Educators (AME) at the University of California, San Francisco (UCSF) designed a streamlined, criteria-based EP (EP 2.0) template highlighting faculty members' recent activities in education and setting rigorous evaluation methods to enable educational scholarship to be objectively evaluated for academic advancement, AME membership, and professional development. OUTCOMES The EP 2.0 template was integrated into the AME application, resulting in high overall satisfaction among candidates and the selection committee and positive feedback on the template's transparency, ease of use, and streamlined format. In 2016, the EP 2.0 template was integrated into the campus-wide curriculum vitae platform and academic advancement system. NEXT STEPS The authors plan to increase awareness of the EP 2.0 template by educating promotions committees and faculty at UCSF and partnering with other institutions to disseminate it for use. They also plan to study the impact of the template on supporting educators by making their important scholarly contributions available for peer review, providing guidance for professional development, and decreasing disparities in promotions.
Effects of taping on pain and function in patellofemoral pain syndrome: a randomized controlled trial.

STUDY DESIGN A randomized controlled trial. OBJECTIVES To investigate the effectiveness of daily patella taping and exercise on pain and function in individuals with patellofemoral pain syndrome. BACKGROUND Patella taping and muscle-strengthening programs are commonly used to treat patellofemoral pain syndrome. There is, however, little evidence for the effectiveness of these approaches. METHODS AND MEASURES Twenty-four men and 6 women aged 17 to 25 years (mean +/- SD, 18.7 +/- 1.2 years) participated in the study. Subjects were randomly and exclusively assigned to 1 of 3 treatment groups: patella taping combined with a standardized exercise program, placebo patella taping and exercise program, or exercise program alone (n = 10 in each group). Taping was applied and exercises performed on a daily basis for 4 weeks. Outcome measures were visual analog scales for pain and the functional index questionnaire, recorded at weekly intervals by a therapist who was blinded to group allocation. RESULTS Separate mixed-model ANOVAs, with repeated measures on time, indicated statistically significant improvements in pain and function over time for all groups (P<.01) and also significant differences between groups for all measures (P<.01). Separate independent samples t tests showed that the group receiving taping and exercises had better pain and function scores following treatment than the placebo taping-and-exercise group and the exercise-alone group. There were no significant differences between the placebo taping-and-exercise group and exercise-alone group at any time point. CONCLUSIONS These findings indicate that over a period of 4 weeks a combination of daily patella taping and exercises was successful in improving pain and function in individuals with patellofemoral pain syndrome. The combination of patella taping and exercise was superior to the use of exercise alone.
Error Analysis of Integrated Resistor Attenuation Network

The model and synthesis method of integrated linear attenuation network (LAC) used in mixed signal SoC for digital instrument are addressed in this paper. The model and synthesis method of the LAC used for electronics instrument is related with the application and implementation method. To the signal generator used in some electronics instrument, the LAC architecture could be linear and synthesized by resistor network and some additional circuits. Therefore, the spectrum properties of the LAC are relayed on the spectrum properties of additional circuits. The synthesis method is derived the formula of the LAC model. With the model, the integrated resistor network in the LAC used for measurement circuit module could be reduced. The LAC architecture synthesis method is suitable for the application of implementing a LAC with integrated circuit technology.
Behavioral Factors Associated with Successful Weight Loss after Gastric Bypass

Patients undergoing bariatric surgery lose substantial weight (≥50% excess weight loss [EWL]), but an estimated 20 per cent fail to achieve this goal. Our objective was to identify behavioral predictors of weight loss after laparoscopic Roux-en-Y gastric bypass. We retrospectively surveyed 148 patients using validated instruments for factors predictive of weight loss. Success was defined as ≥50 per cent EWL and failure as <50 per cent EWL. Mean follow-up after laparoscopic Roux-en-Y gastric bypass was 40.1 ± 15.3 months, with 52.7 per cent of patients achieving successful weight loss. After controlling for age, gender, and preoperative body mass index, predictors of successful weight loss included surgeon follow-up (odds ratio [OR] 8.2, P < 0.01), attendance of postoperative support groups (OR 3.7, P = 0.02), physical activity (OR 3.5, P < 0.01), single or divorced marital status (OR 3.2, P = 0.03), self-esteem (OR 0.3, P = 0.02), and binge eating (OR 0.9, P < 0.01). These factors should be addressed in prospective studies of weight loss after bariatric surgery, as they may identify patients at risk for weight loss failure who may benefit from early tailored interventions.
Small Molecules That Enhance the Catalytic Efficiency of HLA-DM1

HLA-DM (DM) plays a critical role in Ag presentation to CD4 T cells by catalyzing the exchange of peptides bound to MHC class II molecules. Large lateral surfaces involved in the DM:HLA-DR (DR) interaction have been defined, but the mechanism of catalysis is not understood. In this study, we describe four small molecules that accelerate DM-catalyzed peptide exchange. Mechanistic studies demonstrate that these small molecules substantially enhance the catalytic efficiency of DM, indicating that they make the transition state of the DM:DR/peptide complex energetically more favorable. These compounds fall into two functional classes: two compounds are active only in the presence of DM, and binding data for one show a direct interaction with DM. The remaining two compounds have partial activity in the absence of DM, suggesting that they may act at the interface between DM and DR/peptide. A hydrophobic ridge in the DMβ1 domain was implicated in the catalysis of peptide exchange because the activity of three of these enhancers was substantially reduced by point mutations in this area.
Supporting Innovation Through a Mechanism of Accelerated Depreciation in the Republic of Uzbekistan

The state plays a paramount role in the development of the national economy. In this development process, the state with direct levers, using the available tools as state financial support, banks systems, and tax policy, can provide incentives to identify areas for managing business entities. Obviously, one of the main levers of the state policy is a tax policy. Tax policy plays a crucial role in supporting innovation activities, which in turn provide sustainable economic growth for both the economic entities and the state. Whereas, due to guaranty of sustainable production line in the market economy, the economic entity always needs additional financial resources that ensure the renewal of fixed assets. The present paper focuses on the variation of calculations of the depreciation fund in the Republic of Uzbekistan. Regarding to both the tax rates and interval of the residual value of fixed assets, without attracting financial flows, the economic entities can update fixed assets, which on the same time increases the tax payments to the state budget in case of Uzbekistan.