Miracle-dz/UniFAR-FTUs huggingface dataset:
Fluoxetine-induced sexual dysfunction and an open trial of yohimbine.

BACKGROUND Reports of fluoxetine-induced sexual dysfunction have described orgasmic and erectile difficulties but have neglected possible changes in sexual desire. This prospective study was undertaken to determine the percentages of patients experiencing different types of sexual dysfunction after successful antidepressant treatment with standard doses of fluoxetine. Additionally, an open trial of the alpha 2-adrenoceptor blocker yohimbine as a potential treatment for fluoxetine-induced sexual dysfunction was conducted in nine patients. METHOD Over a 2-year period, outpatients who had fulfilled DSM-III-R criteria for major depression and subsequently responded to treatment with fluoxetine 20-40 mg were asked to report and describe changes in sexual function. A small number of consecutive nongeriatric patients complaining of new onset sexual dysfunction were invited to participate in an open trial of yohimbine 5.4 mg t.i. d. RESULTS Fifty-four (34%) of 160 outpatients reported the onset of sexual dysfunction after successful treatment with fluoxetine: 16 (10%) of the 160 patients reported decreased libido, 21 (13%) patients reported decreased sexual response, and 17 (11%) patients reported declines in both areas. Eight of nine patients reported improvement in sexual function with yohimbine, although five patients reported side effects that led to discontinuation in two cases. CONCLUSION These findings suggest that (1) fluoxetine-induced sexual dysfunction may include decreased sexual desire as well as decreased physical functioning and may occur more frequently than previously appreciated and (2) fluoxetine-induced sexual dysfunction may be treatable with yohimbine.
Modulation of Induction Properties of Glucocorticoid Receptor-Agonist and -Antagonist Complexes by Coactivators Involves Binding to Receptors but Is Independent of Ability of Coactivators to Augment Transactivation*

Coactivators such as TIF2 and SRC-1 modulate the positioning of the dose-response curve for agonist-bound glucocorticoid receptors (GRs) and the partial agonist activity of antiglucocorticoid complexes. These properties of coactivators differ from their initially defined activities of binding to, and increasing the total levels of transactivation by, agonist-bound steroid receptors. We now report that constructs of TIF2 and SRC-1 lacking the two activation domains (AD1 and AD2) have significantly less ability to increase transactivation but retain most of the activity for modulating the dose-response curve and partial agonist activity. Mammalian two-hybrid experiments show that the minimum TIF2 segment with modulatory activity (TIF2.4) does not interact with p300, CREB-binding protein, or PCAF, which also modulates GR activities. DRIP150 and DRIP205 have been implicated in coactivator actions but are unable to modulate GR activities. The absence of synergism by PCAF or DRIP150 with SRC-1 or TIF2, respectively, further suggests that these other factors are not involved. The ability of a TIF2.4 fragment (i.e. TIF2.37), which is not known to interact with proteins, to block the actions of TIF2.4 suggests that an unidentified binder mediates the modulatory activity of TIF2. Pull-down experiments with GST/TIF2.4 demonstrate a direct interaction of TIF2 with GR in a hormone-dependent fashion that requires the receptor interaction domains of TIF2 and is equally robust with agonists and most antiglucocorticoids. These observations, which are confirmed in mammalian two-hybrid assays, suggest that the capacity of coactivators such as TIF2 to modulate the partial agonist activity of antisteroids is mediated by the binding of coactivators to GR-antagonist complexes. In conclusion, the modulatory activity of coactivators with GR-agonist and -antagonist complexes is mechanistically distinct from the ability of coactivators to augment the total levels of transactivation and appears to involve the binding to both GR-steroid complexes and an unidentified TIF2-associated factor(s).
An Approach for Detecting Polarity of Online Product Reviews Based on Opinion Target and Opinion Words from Reviews

Online shopping is a medium for many consumers to buy goods and services from E-commerce applications. The public is more inclined to online shopping from the last decade. These online shopping portals also provide the customers a way to express their experience with the product by giving reviews. These reviews not only prove a benefit to the consumer but also help the manufacturer in improving the quality of their products. Our proposed approach works on determining the polarity of the mobile phone’s reviews i.e. positive, negative or neutral using natural language processing techniques. We hope that our proposed model will act as a useful tool for online product review mining.
Undergraduate Knowledge Legitimation Strategies: Metacognition and Epistemological Development.

Undergraduate epistemology typically transitions from an absolute perspective with a reliance on external knowledge authority to a more open epistemology that utilizes metacognition to evaluate knowledge claims. In the undergraduate agricultural classroom, student epistemic development, combined with deeply embedded agricultural beliefs and values, can lead to rigid perspectives that may inhibit effective communication and collaboration between diverse students, and thwart epistemic development necessary for students to entertain and synthesize widely divergent knowledge claims. This research sought to explore the characteristics and sources of knowledge undergraduates considered legitimate, and the internal processes undergraduate agricultural students used to assess the legitimacy of knowledge claims. Findings from this qualitative, multiple case study revealed students utilized specific metacognitive processes to assess the validity of conflicting agricultural knowledge claims. In addition, findings indicated students implemented specific legitimation criteria when assessing professors as credible sources of agricultural knowledge. These findings suggest educators should recognize and validate students’ prior experience, social affiliations, and implement pedagogies that facilitate student learning through dialogue involving students holding diverse agricultural perspectives.
USF1/2 Transcription Factor DNA-Binding Activity Is Induced During Rat Sertoli Cell Differentiation1

Abstract Each Sertoli cell can support a finite number of developing germ cells. During development of the testis, the cessation of Sertoli cell proliferation and the onset of differentiation determine the final number of Sertoli cells and, hence, the number of sperm that can be produced. We hypothesize that the transition from proliferation to differentiation is facilitated by E-box transcription factors that induce the expression of differentiation-promoting genes. The relative activities of E-box proteins were studied in primary Sertoli cells isolated from 5-, 11-, and 20-day-old rats, representing proliferating, differentiating, and differentiated cells, respectively. E-box DNA-binding activity is almost undetectable 5 days after birth but peaks with initiation of differentiation 11 days after birth and remains elevated. Upstream stimulatory factors 1 and 2 (USF1 and USF2) were found to be the predominant E-box proteins present within DNA-protein complexes formed after incubating E-box-containing probes with nuclear extracts from developing Sertoli cells. The known potentiator of Sertoli cell differentiation, thyroxine, increases USF DNA-binding activity in Sertoli cells before differentiation (5-day-old Sertoli cells) but not after differentiation is initiated (11- and 20-day-old Sertoli cells). The developmental-specific increase in USF1 and USF2 DNA-binding activity may facilitate the switch from proliferation to differentiation and, thus, determine the ultimate number of Sertoli cells present within the testes and the upper limit of fertility.
Equivalence of Multi-Time Scale Optimization for Home Energy Management Considering User Discomfort Preference

The problem of home energy management (HEM) optimization can be transformed from single-time scale into multi-time scale to decrease the computational complexity; however, the equivalence of transformation should be guaranteed. In this paper, we investigate the equivalence of multi-time scale HEM optimization, which includes electric vehicles, thermal appliances, and uncontrollable devices. The total electricity cost and user discomfort of temperature are considered. We propose a thermal model in multi-time scale to reduce the error of transformation. We show and prove the equivalent conditions of transformation. Based on the conditions, we present an improved optimization algorithm for the problem of multi-time scale HEM optimization. Numerical results show that the proposed model is more suitable for the transformation, the conditions are obeyed, and the proposed algorithm achieves better performance while solving the problem.
Endothelial Progenitor Cells Homing and Renal Repair in Experimental Renovascular Disease

Tissue injury triggers reparative processes that often involve endothelial progenitor cells (EPCs) recruitment. We hypothesized that atherosclerotic renal artery stenosis (ARAS) activates homing signals that would be detectable in both the kidney and EPCs, and attenuated on renal repair using selective cell‐based therapy. Pigs were treated with intrarenal autologous EPC after 6 weeks of ARAS. Four weeks later, expression of homing‐related signals in EPC and kidney, single kidney function, microvascular (MV) density, and morphology were compared with untreated ARAS and normal control pigs (n = 7 each). Compared with normal EPC, EPC from ARAS pigs showed increased stromal cell‐derived factor (SDF)‐1, angiopoietin‐1, Tie‐2, and c‐kit expression, but downregulation of erythropoietin (EPO) and its receptor. The ARAS kidney released the c‐kit‐ligand stem cell factor, uric acid, and EPO, and upregulated integrin β2, suggesting activation of corresponding homing signaling. However, angiopoietin‐1 and SDF‐1/CXCR4 were not elevated. Administration of EPC into the stenotic kidney restored angiogenic activity, improved MV density, renal hemodynamics and function, decreased fibrosis and oxidative stress, and attenuated endogenous injury signals. The ARAS kidney releases specific homing signals corresponding to cognate receptors expressed by EPC. EPC show plasticity for organ‐specific recruitment strategies, which are upregulated in early atherosclerosis. EPC are renoprotective as they attenuated renal dysfunction and damage in chronic ARAS, and consequently decreased the injury signals. Importantly, manipulation of homing signals may potentially allow therapeutic opportunities to increase endogenous EPC recruitment. STEM Cells 2010;28:1039–1047
A global approach for automatic artifact removal for standard EEG record

The EEG signal is a record of the brain activity using multiple electrodes placed on the scalp. Unfortunately, it can be hardly contaminated by a lot of noises called artifacts. These latter can be generated by various actions such as eye blinks, eye movements or the skeletal muscle activities (jaw, forehead, .). This study will focus on a global artifact removal method using independent component analysis (ICA) on signals cut in frequency bands. The interest of this method resides in automatizing the artifactual source identification and enables a global filtering of records using constant bases. A brief overview of the project will be made in order to introduce the method used. Next, the results will be presented and their validation will be discussed in the conclusion
Evaluation of a volunteer-led in-home exercise program for home-bound older adults.

OBJECTIVE Exercise programs have been found to have substantial benefits for older persons, but implementing these programs with frail homebound seniors is challenging. The project team aimed to evaluate an in-home exercise program for older adults--the Victorian Order of Nurses' for Canada's SMART (Seniors Maintaining Active Roles Together)® (VON SMART®) In-Home Exercise Program- in which the exercises are led by trained volunteers. The majority of volunteers were females who exercise regularly. Over half of the volunteers were 60 years of age or older, and over half had had prior health or fitness training. Volunteers reported receiving multiple benefits from performing their role as an exercise leader. PARTICIPANTS From January to August, 2009, a total of 59 volunteers, seven Site Coordinators, and 33 home-bound older (mean age: 80 years; SD: 8.8) clients from eight VON sites and one partner organization participated in the evaluation. METHODS Data collection included pre-post quantitative measures of participants' physical function, satisfaction surveys of participants, follow up semi-structured interviews of participants, feedback surveys of volunteers and site coordinators, and a focus group interview of site coordinators. RESULTS The Chair Stand test (p<0.001), the Reaching Forward test (p=0.028), the Activities Balance Confidence Scale (p=0.02), as well as measures of activities of daily living (ADL) inside the home (p=0.001) and outside the home (p=0.009) showed significant improvement. CONCLUSIONS This evaluation showed that the exercises improved participants' strength, flexibility, balance, and ability to perform ADL. This study provides additional evidence of the benefits of in-home exercise for frail seniors, and supports a role for volunteers in delivering these programs. The volunteers reported receiving social benefits of meeting new people, being able to see the difference they helped make in others, as well as personal physical benefits from exercising more.
Algorithms and Ordering Heuristics for Distributed Constraint Satisfaction Problems. ("Les algorithmes dans la résolution des problèmes de satisfaction de contraintes distribués")

DisCSP (Distributed Constraint Satisfaction Problem) is a general framework for solving distributed problems arising in Distributed Artificial Intelligence.A wide variety of problems in artificial intelligence are solved using the constraint satisfaction problem paradigm. However, there are several applications in multi-agent coordination that are of a distributed nature. In this type of application, the knowledge about the problem, that is, variables and constraints, may be logically or geographically distributed among physical distributed agents. This distribution is mainly due to privacy and/or security requirements. Therefore, a distributed model allowing a decentralized solving process is more adequate to model and solve such kinds of problem. The distributed constraint satisfaction problem has such properties.ContentsIntroductionPart 1. Background on Centralized and Distributed Constraint Reasoning1. Constraint Satisfaction Problems2. Distributed Constraint Satisfaction ProblemsPart 2. Synchronous Search Algorithms for DisCSPs3. Nogood Based Asynchronous Forward Checking (AFC-ng)4. Asynchronous Forward Checking Tree (AFC-tree)5. Maintaining Arc Consistency Asynchronously in Synchronous Distributed SearchPart 3. Asynchronous Search Algorithms and Ordering Heuristics for DisCSPs6. Corrigendum to Min-domain Retroactive Ordering for Asynchronous Backtracking7. Agile Asynchronous BackTracking (Agile-ABT)Part 4. DisChoco 2.0: A Platform for Distributed Constraint Reasoning8. DisChoco 2.09. ConclusionAbout the AuthorsMohamed Wahbi is currently an associate lecturer at Ecole des Mines de Nantes in France. He received his PhD degree in Computer Science from University Montpellier 2, France and Mohammed V University-Agdal, Morocco in 2012 and his research focused on Distributed Constraint Reasoning.
Proceedings of the Vertebrate Pest Conference Reducing livestock depredation losses in the Nepalese Himalaya

: In the Nepalese Himalaya conflict with rural communities due to livestock predation to large carnivores like snow leopard, common leopard, wolf and wild dog has risen sharply in recent years. This increase is attributed to a number of factors, including implementation and enforcement of wildlife protection laws (which have permitted a recovery in carnivore numbers). the creation of protected areas (which serve as refuges from which predators can populate the surrounding area), the depletion of natural prey due to poaching and loss of habitat, and lax livestock herding practices. However, little information is presently available upon which to design remedial programs. U.S. AID provided research funding for an in depth assessment of snow leopard predation in the Annapurna Conservation Area (ACAP), a new innovative approach to nature conservation. Baseline information on livestock numbers and mortality were gathered during household interviews, followed by field surveys to assess animal husbandry systems, map pastures, establish periods of use and estimate stocking rates, and to characteriz.e habitat using randomly located plots. Data substantiate the erjstence of depredation "hotspots," where high loss occurs, in some cases exceeding 143 to 203 of the livestock population over a short period. Losses varied seasonally, and from year to year. Small-bodied stock like goat and sheep were more vulnerable than large-bodied stock like yak, although horses were especially vulnerable. Factors most closely associated with predation included lack of guarding (or very lax supervision). especially during the daytime, and repeated use of pastures where livestock depredators were known to be actively bunting. Herders usually reacted to repeated depredation incidents by attempting to trap or shoot the suspected culprit until losses declined to an acceptable level. As large carnivore populations become increasingly fragmented and genetically isolated, new management strategies are urgently needed, especially within the buffer rones and intervening corridors between separated parks and reserves. People reside within nearly all Himalayan protected areas, and such issues as loss of livestock and competition between wildlife and livestock cannot be avoided. A plan is offered for alleviating livestock loss in the Annapurna Conservation Area that involves local institutions in decision-making, rewards sound husbandry practices, strengthens indigenous institutions, without further eroding ACAP's unique biological diversity and diverse carnivore population. The authors believe these measures and ideas could be fruitfully extended to other parts of the Himalaya.
Piggery Wastewater Treatment in a Tropical Climate: Biological and Chemical Treatment Options

A novel biological treatment system was developed for the treatment of piggery wastewater under tropical conditions. It consisted of three consecutive sponge-based floating biofilters. The Upflow Anaerobic/Anoxic/Aerobic Floating Filter (UA3FF) system was shown to be effective with carbonaceous and, particularly, nitrogenous matter. The rationale for the processes occurring in anoxic-aerobic reactors was based on the concept of nitritation-denitritation rather than nitrification-denitrification. The N-related microbial communities manipulated by changing DO concentration and hydraulic retention time were able to effect a considerable increase in the total and specific N-removal (70% and 0.6 kg N m−3 filter media per day, respectively) as compared to data reported elsewhere. Fluorescence In Situ Hybridization and Polymerase Chain Reaction amplification of ammonia monooxygenase (amoA) gene were used to study interrelationships between N-related microbial groups in the system. Microbiological data was interpreted in terms of operational behavior and performance of the reactors. The N-removal efficiency of the biological UA3FF system was compared with a combined biological/physicochemical system based on (a) biological anaerobic pretreatment followed by (b) a chemical precipitation (CP) and (c) an air stripping. Both systems were scrutinized as to operational advantages and costs. The treatment options could produce effluent of a high quality (202 mg COD l−1, 126 total-N l−1 and 89 mg COD l−1 48 total-N l−1 in the biological and combined biological/physicochemical treatment options, respectively) amenable for the subsequent treatment at the municipal facilities. However, the UA3 FF biological treatment system was superior to the combined system by a factor of 20 as far as costs are concerned.
Surviving Overwhelming Challenges: Family Caregivers’ Lived Experience of Caring for a Child Diagnosed with HIV and Enrolled in Antiretroviral Treatment in Ethiopia

Family caregivers play a critical role in caring for children living with HIV, however, there is little knowledge about their experiences. The aim of this study was to illuminate the family caregivers’ lived experiences of caring for a child when he or she has been diagnosed with HIV and enrolled to antiretroviral treatment. Qualitative interviews with 21 family caregivers of 21 children diagnosed with HIV were analyzed using an inductive design with a hermeneutic phenomenological approach. The caregivers' experience were articulated in 5 subthemes under the main theme of “Surviving overwhelming challenges”: “Committed care-giving,” “Breaking the family life,” “Caring burdens,” “Confronting conflicts,” and “Living with worry. ” Despite the difficult situation the family caregivers experienced with extensive worry, caring burdens, and disrupted family and social networks, they were committed caregivers. They were empowered by their belief in God but also by their strong belief in the child’s treatment and support from healthcare workers. The healthcare system needs to consider possible ways to support the family caregivers during child’s HIV diagnosis and treatment initiation as part of a continuum of care.
The Inflammatory Potential of the Diet Is Associated with Depressive Symptoms in Different Subgroups of the General Population.

Background: Low-grade chronic inflammation, which can be modulated by diet, has been suggested as an important risk factor for depression, but few studies have investigated the association between the inflammatory potential of the diet and depression.Objective: We investigated the prospective association between the inflammatory potential of the diet, measured by the Dietary Inflammatory Index (DII), and incident depressive symptoms and tested the potential modulating effect of sex, age, physical activity, and smoking status.Methods: This study included 3523 participants (aged 35-60 y) from the SU.VI. MAX (Supplémentation en Vitamines et Minéraux Antioxydants) cohort, who were initially free of depressive symptoms. Baseline DII (1994-1996) was computed by using repeated 24-h dietary records. Incident depressive symptoms were defined by a Center for Epidemiologic Studies-Depression Scale score ≥17 for men and ≥23 for women in 2007-2009. We used multivariable logistic regression models to estimate ORs and 95% CIs, and modeled the DII as a continuous variable and as sex-specific quartiles.Results: A total of 172 cases of incident depressive symptoms were identified over a mean follow-up of 12.6 y. The DII was not associated with incident depressive symptoms in the full sample. In sex-specific models, men with a higher DII had a higher risk of incident depressive symptoms (quartile 4 compared with quartile 1-OR: 2.32; 95% CI: 1.01, 5.35), but the association was only marginally significant (P-trend = 0.06). When analyses were performed across smoking status, current and former smokers with a higher DII had a higher risk of incident depressive symptoms (quartile 4 compared with quartile 1-OR: 2.21; 95% CI: 1.08, 4.52). A positive association was also observed among less physically active participants (quartile 4 compared with quartile 1-OR: 2.07; 95% CI: 1.05, 4.07). Conclusion: The promotion of a healthy diet with anti-inflammatory properties may help to prevent depressive symptoms, particularly among men, smokers, or physically inactive individuals. This trial was registered at clinicaltrials.gov as NCT0027242.