Miracle-dz/UniFAR-FTUs huggingface dataset:
Surface membrane polypeptides associated with hemocytes from Schistosoma mansoni-susceptible and -resistant strains of Biomphalaria glabrata (Gastropoda).

Previous studies have shown that hemocytes from inbred susceptible and resistant strains of the snail, Biomphalaria glabrata, differentially react to primary sporocysts of the blood fluke, Schistosoma mansoni. It has been hypothesized that this differential reactivity may be due to differences in the expression of hemocyte surface determinants serving as parasite recognition and/or hemocyte activating factors. In order to begin addressing this hypothesis the hemodynamics and surface polypeptides of circulating hemocytes from susceptible and resistant B. glabrata strains were compared in two morphologically distinct cellular subpopulations that differed in their substrate adherence properties. When compared to a S. mansoni-resistant snail strain, two susceptible strains exhibited overall lower total circulating cell numbers and a consistently lower proportion of nonadherent hemocytes. Exposure of snails to S. mansoni miracidia induced significant increases in total circulating cell number in all strains by 2 days postexposure (PE). However, the proportion of adherent and nonadherent hemocytes remained constant in each snail strain at 2 and 4 days PE. A sensitive technique involving biotin labeling of polypeptides at the surface of living hemocytes, followed by nonreducing SDS-PAGE separation and electrotransfer to nitrocellulose, revealed a similar pattern of hemocyte surface polypeptides ranging in apparent molecular weights from 210 to 30 kDa in the three B. glabrata strains. One exception was the presence of a 66-kDa polypeptide expressed at the surface of both adherent and nonadherent hemocytes in the two susceptible snail strains, which was only weakly expressed or absent from hemocytes of the resistant 13-16-R1 B. glabrata strain. (ABSTRACT TRUNCATED AT 250 WORDS)
Selective inhibition of histone deacetylase 6 promotes survival in a rat model of hemorrhagic shock

BACKGROUND Hemorrhage is the leading cause of preventable trauma-related deaths. We have previously shown that treatment with Tubastatin A (Tub A), a histone deacetylase 6 (HDAC6) inhibitor, can improve survival in a rodent model of septic shock. The aims of the present study were to determine whether selective inhibition of HDAC6 can promote survival in a model of hemorrhagic shock (HS). METHODS In Experiment I (survival study), Wistar-Kyoto rats were subjected to HS (55% volume blood loss), followed by intraperitoneal injection of either Tub A (70 mg/kg) dissolved in dimethyl sulfoxide (DMSO) or DMSO only (vehicle group) (n = 8 per group). Survival was monitored for 24 hours. In Experiment II (physiologic study), rats were subjected to a sublethal HS (40% blood loss), followed by the same treatment with Tub A (treatment group) or DMSO only (vehicle group, n = 5 per group). All animals were sacrificed 6 hours after hemorrhage, and the heart and liver tissues were harvested. Sham animals were not subjected to hemorrhage and treatment (sham group, n = 5 per group). Cardiac mitochondria were isolated to study the pyruvate dehydrogenase (PDH, an essential enzyme for adenosine triphosphate production) activity. Liver tissue lysates were analyzed for markers of apoptosis (cytochrome c, cleaved caspase 3) and inflammation (high-mobility group box 1) by Western blotting. RESULTS Severe HS (55% blood loss) was associated with 75% mortality, which was significantly improved by Tub A treatment (37.5% mortality in 24 hours, p = 0.048). Tub A also significantly enhanced the cardiac PDH activity compared with the vehicle group, while suppressing the hepatic high-mobility group box 1 expression, cytochrome c release, and caspase 3 activation. CONCLUSION Our study has demonstrated for the first time that selective inhibition of HDAC6 can improve survival in a rodent model of HS. The potential mechanisms include enhanced PDH activity, decreased inflammatory drive, and attenuated cellular apoptosis.
Biodegradable chitin conduit tubulation combined with bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury by reducing glial scar and cavity formation

We examined the restorative effect of modified biodegradable chitin conduits in combination with bone marrow mesenchymal stem cell transplantation after right spinal cord hemisection injury. Immunohistochemical staining revealed that biological conduit sleeve bridging reduced glial scar formation and spinal muscular atrophy after spinal cord hemisection. Bone marrow mesenchymal stem cells survived and proliferated after transplantation in vivo, and differentiated into cells double-positive for S100 (Schwann cell marker) and glial fibrillary acidic protein (glial cell marker) at 8 weeks. Retrograde tracing showed that more nerve fibers had grown through the injured spinal cord at 14 weeks after combination therapy than either treatment alone. Our findings indicate that a biological conduit combined with bone marrow mesenchymal stem cell transplantation effectively prevented scar formation and provided a favorable local microenvironment for the proliferation, migration and differentiation of bone marrow mesenchymal stem cells in the spinal cord, thus promoting restoration following spinal cord hemisection injury.
SPAms: A user‐friendly software to simulate population genetics data under complex demographic models

Patterns of genetic diversity can be used to reconstruct populations demographic history. Thus, it is crucial to understand the statistical properties of data sets generated under different scenarios. SPAms is a graphical application that allows the simulation of data under a set of demographic models of increasing complexity: (i) population size change (ii) admixture and (iii) population structure (n‐island or stepping stone model). SPAms generates data under the infinite site and the stepwise mutation models and computes a set of commonly used statistics. It should thus be a useful tool for both research and teaching purposes.
Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases

Plants produce an immense diversity of natural products (i.e. secondary or specialized metabolites) that offer a rich source of known and potentially new pharmaceuticals and other desirable bioproducts. The Traditional Chinese Medicinal plant Isodon rubescens (Lamiaceae) contains an array of bioactive labdane-related diterpenoid natural products. Of these, the ent-kauranoid oridonin is the most prominent specialized metabolite that has been extensively studied for its potent antimicrobial and anticancer efficacy. Mining of a previously established transcriptome of I. rubescens leaf tissue identified seven diterpene synthase (diTPSs) candidates. Here we report the functional characterization of four I. rubescens diTPSs. IrTPS5 and IrTPS3 were identified as an ent-copalyl diphosphate (CPP) synthase and a (+)-CPP synthase, respectively. Distinct transcript abundance of IrTPS5 and the predicted ent-CPP synthase IrTPS1 suggested a role of IrTPS5 in specialized ent-kaurene metabolism possibly en route to oridonin. Nicotiana benthamiana co-expression assays demonstrated that IrTPS4 functions sequentially with IrTPS3 to form miltiradiene. In addition, IrTPS2 converted the IrTPS3 product (+)-CPP into the hydroxylated tricyclic diterpene nezukol not previously identified in I. rubescens. Metabolite profiling verified the presence of nezukol in I. rubescens leaf tissue. The proposed IrTPS2-catalyzed reaction mechanism proceeds via the common ionization of the diphosphate group of (+)-CPP, followed by formation of an intermediary pimar-15-en-8-yl+ carbocation and neutralization of the carbocation by water capture at C-8 to yield nezukol, as confirmed by nuclear magnetic resonance (NMR) analysis. Oxygenation activity is rare for the family of class I diTPSs and offers new catalysts for developing metabolic engineering platforms to produce a broader spectrum of bioactive diterpenoid natural products.
Minorities in the Farmers Home Administration

This research investigates the intra-agency employment patterns of African Americans, Hispanics, Asian Americans, and Native Americans in the Farmers Home Administration. Drawing on previous studies of local, state, and federal employment, this article develops and tests a model to explain employment variation within a federal agency This research uses weighted least squares regression to analyze integration in 246 Farmers Home Administration (FmHA) district offices. The findings indicate that group population, upper-level agency representatvon, funding, interminority competition, and region are important determinants of minority employment.
Motion Correlation

Selection is a canonical task in user interfaces, commonly supported by presenting objects for acquisition by pointing. In this article, we consider motion correlation as an alternative for selection. The principle is to represent available objects by motion in the interface, have users identify a target by mimicking its specific motion, and use the correlation between the system’s output with the user’s input to determine the selection. The resulting interaction has compelling properties, as users are guided by motion feedback, and only need to copy a presented motion. Motion correlation has been explored in earlier work but only recently begun to feature in holistic interface designs. We provide a first comprehensive review of the principle, and present an analysis of five previously published works, in which motion correlation underpinned the design of novel gaze and gesture interfaces for diverse application contexts. We derive guidelines for motion correlation algorithms, motion feedback, choice of modalities, overall design of motion correlation interfaces, and identify opportunities and challenges identified for future research and design.
Toward high level data fusion for conflict resolution

Conflict resolution is the problem of finding true value among different and controversial facts about a single entity provided by different data sources such as web sites. All of the previous studies have relied on estimating two basic parameters, accuracy of data and reliability of sources. These methods are dealing with some challenges such as knowing distribution of data a priori or assumption about dependency of sources which are due to low level fusion. In lower levels of data fusion we usually engage with details of data generation process, while in higher levels of abstraction the relationship between objects becomes more important. In this paper, we propose the approach of High Level Conflict Resolution (HLCR) based on graphical model for conflict resolution which performs in high level data fusion and uses the relations between objects for inferring truth value. We have specified the well-known JDL model for the problem of conflict resolution. Evaluation results showed that our proposed approach outperforms existing conflict resolution techniques especially where the number of reliable sources is low.
Predicting NCLEX-RN Success: The Seventh Validity Study HESI Exit Exam

The findings of six previously conducted studies indicated that the HESI (E2) was highly accurate in predicting NCLEX-RN success. The purpose of this study—the seventh study to investigate the validity of the E2—was to examine the accuracy of three parallel versions of the E2in predicting licensure success and to describe program practices regarding E2 benchmark scores, remediation programs, and retesting policies. The findings of this study again indicated that the E2 was highly accurate in predicting NCLEX-RN success. Additionally, all three versions of the E2 were found to have a predictive accuracy above 90%. The most common E2 benchmark score designated by faculty at the participating schools was 850, and most schools required students to retest with different versions of the E2 until the faculty-designated E2 benchmark score was achieved. Remediation seemed to be effective in raising students’ E2 scores, and it was recommended that future research investigate the effectiveness of specific remediation strategies.
Notice of RetractionTypology and influence analysis of opinion leader: A case study on fashion online shopping

Opinion leaders of online fashion have a strong influence on online shopping. Through in-depth research interviews with opinion leaders and online shoppers, this paper identified the characteristics and highlights of opinion leaders. The authors suggest the existence of four types of opinion leader online, which are labeled stars & model with Blog, Web celebrity, opinion leader in BBS, opinion leader with Web-shop. By questionnaire survey and one way ANOA, the authors found that first group with reference to opinion leader average score is higher influenced by families or friends, recommended by opinion leader, asking opinions from others, and lower at persuade others to buy clothing I like. Implications of this typology for theory and practice are discussed.
Stochastic volatility options pricing with wavelets and artificial neural networks

Abstract The paper describes an alternative options pricing method which uses a binomial tree linked to an innovative stochastic volatility model. The volatility model is based on wavelets and artificial neural networks. Wavelets provide a convenient signal/noise decomposition of the volatility in the nonlinear feature space. Neural networks are used to infer future volatility from the wavelets feature space in an iterative manner. The bootstrap method provides the 95% confidence intervals for the options prices. Market options prices as quoted on the Chicago Board Options Exchange are used for performance comparison between the Black‐Scholes model and a new options pricing scheme. The proposed dynamic volatility model produces as good as and often better options prices than the conventional Black‐Scholes formulae.
Assessment of Anger-Related Cognitions of People with Intellectual Disabilities.

BACKGROUND Interventions for anger represent the largest body of research on the adaptation of cognitive behavioural therapy (CBT) for people with intellectual disabilities. The extent to which the effectiveness of these interventions reflects the behavioural or cognitive components of CBT is uncertain. This arises in part because there are few measures of anger-related cognitions. METHOD The Profile of Anger-related Cognitions (PAC) is built around interpersonal scenarios that the participant identifies as personally anger-provoking, and was designed as an extension of the Profile of Anger Coping Skills (PACS). A conversational presentational style is used to approach ratings of anger experienced in those situations and of four relevant cognitive dimensions: attribution of hostile intent, unfairness, victimhood, and helplessness. The PAC, and other measures, including the PACS, was administered to (i) people with ID identified as having problems with anger control (n = 12) and (ii) university students (n = 23); its psychometric properties were investigated and content analyses were conducted of participants' verbal responses. In a third study, clinicians (n = 6) were surveyed for their impression of using the PAC in the assessment of clients referred for help with anger problems. RESULTS The PAC had good consistency and test-retest reliability, and the total score on the four cognitive dimensions correlated significantly with anger ratings but not with impersonal measures of anger disposition. The predominant cognitions reported were perceptions of unfairness and helplessness. People with ID and university students were in most respects very similar in both the psychometric analyses and the content analyses of their verbal responses. The PAC had high acceptability both to people with ID and to clinicians. CONCLUSIONS The PAC may be a useful instrument for both clinical and research purposes. Personal relevance and the conversational mode of administration are particular strengths.
The Relationship Between Demographic Characteristics and Socialization Outcomes Among New Employees in Hong Kong Hotels

Abstract High turnover among new hotel employees has become a major concern for Hong Kong hotel managers. Previous studies have shown that the demographic characteristics of employees are related to their subsequent behavior and attitude. However, there is little vigorous discussion on new employees in particular. This study examines the relationship between the demographic characteristics of new employees and their socialization outcomes in the Hong Kong hotel industry. Its findings show that there are significant differences between the effects of certain demographic characteristics on job satisfaction, organizational commitment and turnover intentions. Some recommendations for maintaining new employees' productivity and minimizing turnover intentions are made for hotel managers' consideration.
A Mobile Medical Care Approach Targeting Underserved Populations in post-Hurricane Katrina Mississippi

On August 29, 2005, Hurricane Katrina devastated the Gulf Coast Mississippi region, damaging health care infrastructure and adversely affecting the health of populations left behind. Operation Assist, a project of the Children's Health Fund and the Columbia University Mailman School of Public Health, operated mobile medical units to provide health services to underserved populations in the affected areas. Data collected from all patient encounters from September 5–20, 2005 demonstrate that in addition to common respiratory illnesses, skin conditions, and minor injuries, a high proportion of visits were for vaccine administration and chronic medical problems including hypertension, diabetes, and asthma. Mobile medical units staffed by primary care clinicians experienced in dealing with the clinical and social needs of the underserved and comfortable working in a resource-poor environment can make a positive contribution to post-disaster care.
Money Supply in a Simple Economic Growth Model and Multiple Steady States Equilibria

We intend to examine a monetary economic growth model a la Sidrauski-Brock where money is introduced both in the utility function and the production function. We assume that utility is derived from the flow of services derived from real money holdings and that money is held by firms to facilitate production. We show that the level of equilibrium depends on the rate of discount. We give conditions to guarantee uniqueness of the equilibrium. We demonstrate that the unique equilibrium is either a classical 'saddle point' or a 'source point'; that the introduction of money in the utility and production function is sufficient to produce multiple stationary equilibria; and that the initial stock of money appears as an important economic control variable. Therefore, the initial amount of the monetary emission issued by the central bank becomes essential for the long run economic equilibrium properties.
MIGRATION AMONGST THE BATSWANA

The present study undertakes analysis of the effects of employment probabilities and wage alternatives on migration decisions in the context of Botswana adopting micro level data both [to estimate] a multinomial migration function and to develop prediction equations for wages and likelihood of employment. Data are from the 1978-1979 National Migration Survey. The factors that influence rural Batswana adults to remain at home migrate to town on a short- or long-term basis move to another rural area or emigrate to South Africa are examined. Consideration is given to "the effects of employment alternatives on the rate of internal migration and the selectivity of movements with respect to personal household and locational factors. " (EXCERPT)
Evaluating Service System Alternatives via a Computer Simulation‐enabled MCDM Framework

Decision makers in the service industry must effectively cope with queuing problems, service capacity optimization, service efficiency and service quality problems. This study proposes a computer simulation‐enabled MCDM framework that integrates computer simulation analysis, Taguchi method, expert opinion and multiple criteria decision making (MCDM) to assist decision makers in coping with decision problems. In this framework, Taguchi method is adopted to reduce the time required for the simulation experiment. Computer simulation analysis is adopted to obtain useful information for rapid decision‐making without interrupting actual production. MCDM is used to select the optimal alternative. The illustrative result is extremely promising.
Differences in somatic and dendritic specific membrane resistivity of spinal motoneurons: an electrophysiological study of neck and shoulder motoneurons in the cat.

1. The voltage response to a hyperpolarizing current step was used to estimate the electrotonic structure of neck and shoulder motoneurons in anesthetized cats. The coefficients (a0 and a1) and time constants (tau 0 and tau 1) of the first two exponential terms of the series of exponential terms whose sum represented the slope of the voltage response were calculated using a standardized "peeling" technique. 2. Input resistance, membrane time constant, and electrotonic length were similar to values reported for other spinal motoneurons. The voltage response of most neck and shoulder motoneurons had a slow, nonlinear component, commonly known as sag, which is also a feature of other spinal motoneurons. Estimates of motoneuron surface area were up to two times larger than the surface area of hindlimb motoneurons. 3. It was possible to estimate electrotonic length and the ratio of the dendritic conductance to the somatic conductance using Johnston's technique for only 6 of 51 motoneurons examined. The responses of these motoneurons were identical to the responses of equivalent cylinder models that had an electrotonic structure derived from the application of Johnston's technique. 4. We were unable to use Johnston's technique for the remaining motoneurons because the ratio, a1/a0, exceeded 2.0. For these motoneurons it was usually impossible to find an equivalent cylinder model whose response matched the experimental data. The failure of equivalent cylinder models to accurately predict the responses of neck and shoulder motoneurons could not be attributed to the sag process or the dendritic geometry of these cells. 5. The electrotonic structure of a group of these motoneurons was further examined using the somatic shunt model developed by Durand and Kawato. After shifting the base line of the experimental records by 1-2 mV in the depolarizing direction, it was possible to find a somatic shunt model whose response was identical to the experimentally recorded voltage response. (ABSTRACT TRUNCATED AT 400 WORDS)
Assets and neighborhoods: The role of individual assets in neighborhood revitalization

Abstract Asset‐building strategies—including individual development accounts, homeownership programs, and microenterprise development—became increasingly popular in the 1990s. Although research has demonstrated how assets produce individual benefits, less is known about the extent to which these benefits induce positive place‐based effects. We develop a model of the relationship between individual asset‐building strategies and neighborhood revitalization in order to inform future empirical work and help ensure that asset accumulation and neighborhood revitalization are mutually reinforcing. Our model emphasizes the conditions and programmatic factors that may encourage and discourage the transfer of benefits from individuals to neighborhoods. Examples from case studies of four community‐based organizations suggest that the likelihood of neighborhood spillovers may be increased if policies and practices aim to “manage” the returns from the individual asset, retain asset holders, provide reinvestment conduits, track local purchasing power, and create additional opportunities for collective action.