Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term weight-loss maintenance in obese patients with knee osteoarthritis: a randomized trial.

Background: A formula low-energy diet (LED) reduces weight effectively in obese patients with knee osteoarthritis, but the role of LED in long-term weight-loss maintenance is unclear.Objective: We aimed to determine the effect of intermittent LED compared with daily meal replacements on weight-loss maintenance and number of knee replacements over 3 y.Design: The design was a randomized trial with participants aged >50 y who had knee osteoarthritis and a body mass index [BMI (in kg/m2)] ≥30. Participants were recruited from the osteoarthritis outpatient clinic at Copenhagen University Hospital in Frederiksberg, Denmark; they had previously completed a 68-wk lifestyle intervention trial and achieved an average weight loss of 10.5 kg (10% of initial body weight). Participants were randomly assigned to either the intermittent treatment (IN) group with LED for 5 wk every 4 mo for 3 y or to daily meal replacements of 1-2 meals for 3 y [regular (RE) group]. Attention by dietitians and the amount of formula products were similar. Primary outcomes were changes in body weight and proportion of participants receiving knee replacements. Outcomes were analyzed on the intention-to-treat-population with the use of baseline-carried-forward imputation for missing data.Results: A total of 153 participants (means ± SDs: BMI: 33.3 ± 4.6; age: 63.8 ± 6.3 y; 83% women) were recruited between June and December 2009 and randomly assigned to the IN (n = 76) or RE (n = 77) group. A total of 53 and 56 participants, respectively, completed the trial. Weight increased by 0.68 and 1.75 kg in the IN and RE groups, respectively (mean difference: -1.06 kg; 95% CI: -2.75, 0.63 kg; P = 0.22). Alloplasty rates were low and did not differ (IN group: 8 of 76 participants; RE group: 12 of 77 participants; P = 0.35). Conclusions: After a mean 10% weight-loss and 1-y maintenance, additional use of daily meal replacements or intermittent LED resulted in weight-loss maintenance for 3 y. These results challenge the commonly held assumption that weight regain in the long term is inevitable. This trial was registered at clinicaltrials.gov as NCT00938808.
Identification of human–carnivore conflict hotspots to prioritize mitigation efforts

Abstract Human–carnivore conflict is a primary driver of carnivore declines worldwide and resolving these conflicts is a conservation priority. However, resources to mitigate conflicts are limited and should be focused on areas of highest priority. We conducted 820 semistructured interviews with community members living within Kenya's Maasai Mara ecosystem. A multiscale analysis was used to determine the influence of husbandry and environmental factors on livestock depredation inside livestock enclosures (bomas). Areas with a high proportion of closed habitat and protected areas had the highest risk of depredation. Depredation was most likely to occur at weak bomas and at households where there were fewer dogs. We used the results to identify potential conflict hotspots by mapping the probability of livestock depredation across the landscape. 21.4% of the landscape was classified as high risk, and within these areas, 53.4% of the households that were interviewed had weak bomas. Synthesis and applications. With limited resources available to mitigate human–carnivore conflicts, it is imperative that areas are identified where livestock is most at risk of depredation. Focusing mitigation measures on high‐risk areas may reduce conflict and lead to a decrease in retaliatory killings of predators.
Operation Everest II: muscle energetics during maximal exhaustive exercise.

To investigate the metabolic basis for the reduction in peak blood lactate concentration that occurs with maximal exercise after acclimatization to altitude, eight male subjects [maximal O2 uptake of 51.2 +/- 3.0 (SE) ml.kg-1.min-1] were acclimated to progressive hypobaria over a 40-day period. Before decompression (SL-1), at 380 and 282 Torr, and on return to sea level (SL-2) the subjects performed progressive cycle exercise to exhaustion. Analysis of muscle samples obtained from the vastus lateralis before exercise and at exhaustion indicated a pronounced reduction (P less than 0.05) in muscle lactate concentration (mmol/kg dry wt) at 282 Torr (39.2 +/- 11) compared with SL-1 (113 +/- 9.7), 380 Torr (94.6 +/- 18), and SL-2 (92.7 +/- 22). For the other glycolytic intermediates studied (glucose 1-phosphate, glucose 6-phosphate, fructose 6-phosphate, fructose 1,6-bisphosphate, and pyruvate) only the increase in glucose 1-phosphate, glucose 6-phosphate, and fructose 6-phosphate were blunted (P less than 0.05) at 282 Torr. The reduction in muscle glycogen concentration during exercise was similar (P less than 0.05) for all environmental conditions. Although exercise resulted in reductions (P less than 0.05) in ATP and creatine phosphate averaging 30 and 51%, respectively, the magnitude of the change was not dependent on the degree of hypobaria. Inosine monophosphate was elevated (P less than 0.05) approximately 11-fold with exercise at both SL-1 and SL-2. These findings support the hypothesis that the lower lactate concentration observed at 282 Torr after exhaustive exercise is due to a reduction in anaerobic glycolysis. (ABSTRACT TRUNCATED AT 250 WORDS)
Early interim 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography is prognostically superior to international prognostic score in advanced-stage Hodgkin's lymphoma: a report from a joint Italian-Danish study.

PURPOSE Starting from November 2001, 260 newly diagnosed patients with Hodgkin's lymphoma (HL) were consecutively enrolled in parallel Italian and Danish prospective trials to evaluate the prognostic role of an early interim 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) scan and the International Prognostic Score (IPS) in advanced HL, treated with conventional ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) therapy. PATIENTS AND METHODS Most patients (n = 190) presented with advanced disease (stages IIB through IVB), whereas 70 presented in stage IIA with adverse prognostic factors. All but 11 patients were treated with standard ABVD therapy followed by consolidation radiotherapy in case of bulky presentation or residual tumor mass. Conventional radiologic staging was performed at baseline. FDG-PET scan was performed at baseline and after two courses of ABVD (PET-2). No treatment change was allowed on the basis of the PET-2 results. RESULTS After a median follow-up of 2.19 years (range, 0.32 to 5.18 years), 205 patients were in continued complete remission and two patients were in partial remission. Forty-three patients progressed during therapy or immediately after, whereas 10 patients relapsed. The 2-year progression-free survival for patients with positive PET-2 results was 12.8% and for patients with negative PET-2 results was 95.0% (P < .0001). In univariate analysis, the treatment outcome was significantly associated with PET-2 (P < .0001), stage IV (P < .0001), WBC more than 15,000 (P < .0001), lymphopenia (P < .001), IPS as a continuous variable (P < .0001), extranodal involvement (P < .0001), and bulky disease (P = .012). In multivariate analyses, only PET-2 turned out to be significant (P < .0001). CONCLUSION PET-2 overshadows the prognostic value of IPS and emerges as the single most important tool for planning of risk-adapted treatment in advanced HL.
Effect of Amphotericin B and Rifampin Against Coccidioides immitis In Vitro and In Vivo

Amphotericin B, the principal drug used for treating systemic mycoses, possesses undesirable toxic properties. The ability of this antibiotic to potentiate antifungal activity of other compounds suggests that lower doses of amphotericin B could be used in combination with a second drug without loss of therapeutic efficacy. In vitro tests demonstrated that amphotericin B potentiated rifampin against the mycelial growth phase of Coccidioides immitis but not against the spherule-endospore phase. Therapy for murine coccidioidomycosis with a combined amphotericin B-rifampin regimen was not better than treatment with amphotericin B alone; in fact, combined drugs may have been even less effective. This would have clinical significance for therapy of concurrent infections.
Forecasting in long horizons using smoothed direct forecast

This paper constructs a forecast method that obtains long horizon forecasts with improved performance through modification of the direct forecast approach. Direct forecasts are more robust to model misspecification compared to iterated forecasts, which makes them preferable in long horizons. However, direct forecast estimates tends to have jagged shapes across horizons. Our forecast method aims to “smooth out” erratic estimates across horizons while maintaining the robust aspect of direct forecasts through ridge regression, which is a restricted regression on the first differences of regression coefficients. The forecasts are compared to the conventional iterated and direct forecasts in two empirical applications: real oil prices and U.S. macroeconomic series. In both applications, our method shows improvement over direct forecasts. JEL classification: C22; C53; E37
Improved accuracy of sensorless position estimation by combining resistance- and inductance-based saliency tracking

At standstill and low-speed, signal-injection methods are required to estimate the rotor position of a permanent magnet synchronous machine (PMSM). Therefore, usually either the resistance- or inductance-based saliency is examined. Although the latter case can be found most in literature, it is possible that the sensorless performance can be improved by exploiting the position information of both saliencies at the same time instead of evaluating only one of both. Therefore, this paper proposes a modified position estimation method which combines both the resistance- and inductance-based saliency. Based on measurement results of a PMSM, the new method is compared to the sole resistance- and inductance-based saliency tracking.
Are polymorphisms in metabolism protective or a risk for reduced white blood cell counts in a Chinese population with low occupational benzene exposures?

Abstract Background: Genetic variations in metabolic enzyme genes may enhance hematotoxicity in benzene-exposed populations. Objective: To investigate the association between polymorphisms of metabolism genes and white blood cells (WBCs). Methods: Three hundred and eighty-five benzene-exposed workers and 220 unexposed indoor workers were recruited in China. We explored the relationship between metabolic enzymes polymorphisms [glutathione S-transferase T1/M1 (GSTT1/M1) null, glutathione S-transferase P1 (GSTP1)rs1695, Cytochrome P450 2E1 (CYP2E1) rs3813867, rs2031920, rs6413432, microsomal epoxide hydrolase (mEH) rs1051740, rs2234922] by polymerase chain reaction (PCR)–restriction fragment length polymorphism (RFLP) analysis and WBC. Results: The exposed group had lower WBC counts (P<0·001) than the unexposed group. Increased susceptibility to hematotoxicity, as evidenced by lower WBC counts, was found in workers with null-GSTT1 (P = 0·045), null-GSTM1 (P = 0·030), rs2031920 (P = 0·020), and rs3813867 (P = 0·014) genotypes. White blood cell counts were also lower in workers with null-GSTT1 and null-GSTM after adjusting for age, gender, smoking, and alcohol consumption. Conclusion: Null-GSTT1 and null-GSTM1 genotypes and Cytochrome P4502E1 (CYP2E1: rs2031920, rs3813867) may support the hematotoxicity of benzene-exposed workers in China, and we can make use of it to select susceptible population.
Healthcare access in Bosnia and Herzegovina in the light of European Union accession efforts

European Union (EU) member states are bound to ensure accessible, good quality healthcare for all of their citizens. In 2018, Bosnia and Herzegovina has been named as a candidate for accession to EU membership as part of the “Strategy for the Western Balkans”. This scoping review identifies healthcare access issues in the country, aiming to inform policy-makers of challenges that may be faced in a possible membership application process and beyond. While the country has seemingly improved citizens’ healthcare access—as measured by the Healthcare Access and Quality Index—various specific problems remain unresolved. The main barrier to equal access appears to lie in the division of the healthcare system between the Federation of Bosnia and Herzegovina, the Republika Srpska, and the Brcko District, which also influences medicine availability and pricing. Although not necessarily systematic, studies further report distance from healthcare providers, alleged widespread corruption, discrimination of minorities and vulnerable populations, as well as vaccination gaps as problems in healthcare access for specific groups. While certainly not easy to realise, this scoping review concludes that possible solutions could include efforts to unify the healthcare and pricing system, and the implementation of the World Health Organization’s Essential Medicines List, as well as investigating and tackling corruption and stigma issues.
Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice

Suckling mice are protected against murine rotavirus-induced gastroenteritis after adoptive transfer of splenic lymphocytes from immunized animals. Adoptive transfer of Thy1(+)-depleted or CD8(+)-depleted lymphocytes abrogated protection against challenge. (We previously found that depletion of Thy1+ or CD8+ lymphocytes from rotavirus-immunized mice decreased rotavirus-specific cytotoxic activity in vitro.) Protection against disease occurred in the absence of rotavirus-specific neutralizing antibodies in the sera of suckling mice. Rotavirus-specific cytotoxic T lymphocytes may be important in either amelioration of acute infection or protection against reinfection.
Textual Spanning: Finding Discursive Holes in Text Networks

We propose a measure of discursive holes well suited for the unique properties of text networks built from document similarity matrices considered as dense weighted graphs. In this measure, which we call textual spanning, documents similar to documents dissimilar from one another receive a high score, and documents similar to documents similar to one another receive a low score. After offering a simulation-based validation, we test the measure on an empirical document similarity matrix based on a preestimated topic-model probability distribution. The results demonstrate that our proposed textual spanning measure captures different structural features of discursive fields than alternative measures.
TRADE BALANCE AND TERMS OF TRADE RELATIONSHIP: Evidence from Pakistan

The terms of trade (TOT) have an important role in determining direction of the trade which finally transmits into trade balance. The current study is an effort to seek the effect of TOT on the trade balance. The short and long-estimates are computed through Autoregressive Distributed Lag (ARDL) methodology; the results reveal that in the case of Pakistan, there is no significant relationship between TOT and trade balance. Furthermore, the estimated Marshall Lerner (ML) condition is calculated by addition of the absolute values of import and export demand elasticities. The study shows that it does not hold for Pakistan, neither in the short-run, nor in the long-run. The computed ML condition, evidently infers that price have negative impact on trade balance. The demand for exports and imports are price inelastic; thus, to curtail trade balance the government should take measures to increase exports and limit the unnecessary imports.
Does Financial Constraint Impede the Innovative Investment? Micro Evidence from China

ABSTRACT This study is among one of relatively few to test for financial constraints on corporate intangible investment behavior. We provide new evidence on the influence that financing constraints have on innovation investment using data of Chinese industrial firms during 1998–2006. By employing the system Generalized Method of Moments to overcome the endogeneity problem of large dynamic panel data, we find that non-state and foreign-owned firms exhibit positive and statistically significant sensitivity of innovation investment to cash flow, while state-owned enterprises (SOEs) do not. In addition, among firms with these characteristics, short-term banking finance and smoothing function of net working capital play significantly positive roles in financing innovation investment not only for SOEs but also for non-state and foreign firms. Our results are robust to a battery of sensitivity checks.
Evaluation of Two Commercial Enzyme Immunoassays, Testing Immunoglobulin G (IgG) and IgA Responses, for Diagnosis ofHelicobacter pylori Infection in Children

ABSTRACT Serological testing to diagnose Helicobacter pyloriinfection in children is still controversial, although commonly used in clinical practice. We compared the immunoglobulin G (IgG) and IgA results of two commercially available enzyme immunoassays (EIAs) (Pyloriset IgG and IgA and Enzygnost II IgG and IgA) for 175 children with abdominal symptoms divided into three age groups (0 to ≤6 years,n = 47; >6 to ≤12 years, n = 77; >12 years, n = 51). A child was considered H. pylori infected if at least two of three tests (histology, rapid urease test, 13C-urea breath test) or culture were positive and noninfected if all results were concordantly negative. Of 175 children, 93 (53%) were H. pylori negative and 82 wereH. pylori positive. With the recommended cutoff values, the overall specificity was excellent for all four EIAs (95.7 to 97.8%) regardless of age. Sensitivity varied markedly between tests and was 92.7, 70.7, 47.5, and 24.4% for Enzygnost II IgG, Pyloriset IgG, Enzygnost II IgA, and Pyloriset IgA, respectively. Sensitivity was low in the youngest age group (25 to 33.3%), except for Enzygnost II IgG (91.6%). Receiver-operating curve analyses revealed that lower cutoff values would improve the accuracy of all of the tests except Enzygnost II IgG. Measurement of specific IgA, in addition to IgG, antibodies hardly improved the sensitivity. The specificity of commercial serological tests is high in children when the cutoff values obtained from adults are used. In contrast, sensitivity is variable, with a strong age dependence in some, but not all, tests. We speculate that young children may have a different immune response to H. pylori, with preferable responses to certain antigens, as well as lower titers than adults. The Pyloriset test may fail to recognize these specific antibodies.
Okun’s Law: an Empirical Test Using Brazilian Data

In this paper, we test Okun’s coefficient to determine if the relationship between GDP and the employment rate holds true for the Brazilian economy during our testing period. Using quarterly data ranging from 1997Q1 to 2015Q2, we develop a finite distributed lag model so that we can examine the relationship between the change in the unemployment rate as the dependent variable and the growth rate in GDP as the independent variable. Our findings indicate that the Okun’s coefficient is significant at 1 lag of GDP in our model. Our estimate of Okun’s coefficient is -0.140473.
Developing privacy solutions for sharing and analysing healthcare data

The extensive use of electronic health data has increased privacy concerns. While most healthcare organizations are conscientious in protecting their data in their databases, very few organizations take enough precautions to protect data that is shared with third party organizations. Recently the regulatory environment has tightened the laws to enforce privacy protection. The goal of this research is to explore the application of data masking solutions for protecting patient privacy when data is shared with external organizations for research, analysis and other similar purposes. Specifically, this research project develops a system that protects data without removing sensitive attributes. Our application allows high quality data analysis with the masked data. Dataset-level properties and statistics remain approximately the same after data masking; however, individual record-level values are altered to prevent privacy disclosure. A pilot evaluation study on large real-world healthcare data shows the effectiveness of our solution in privacy protection.
Training and search methods for speech recognition.

Speech recognition involves three processes: extraction of acoustic indices from the speech signal, estimation of the probability that the observed index string was caused by a hypothesized utterance segment, and determination of the recognized utterance via a search among hypothesized alternatives. This paper is not concerned with the first process. Estimation of the probability of an index string involves a model of index production by any given utterance segment (e.g., a word). Hidden Markov models (HMMs) are used for this purpose [Makhoul, J. & Schwartz, R. (1995) Proc. Natl. Acad. Sci. USA 92, 9956-9963]. Their parameters are state transition probabilities and output probability distributions associated with the transitions. The Baum algorithm that obtains the values of these parameters from speech data via their successive reestimation will be described in this paper. The recognizer wishes to find the most probable utterance that could have caused the observed acoustic index string. That probability is the product of two factors: the probability that the utterance will produce the string and the probability that the speaker will wish to produce the utterance (the language model probability). Even if the vocabulary size is moderate, it is impossible to search for the utterance exhaustively. One practical algorithm is described [Viterbi, A. J. (1967) IEEE Trans. Inf. Theory IT-13, 260-267] that, given the index string, has a high likelihood of finding the most probable utterance.
Detection of Small Changes in Psoriasis Intensity with PrecisePASI

Background: The Psoriasis Area and Severity Index (PASI) is the score of choice to grade psoriasis severity and detect clinical changes. Due to low resolution based on the calculation of the score by fixed area classes, PASI scores <10 have little value. Methods: At 756 patient examinations, psoriasis activity was measured with both PASI and PrecisePASI. Results: PrecisePASI has a linear increase while PASI has a staircase pattern. Both scores meet at the endpoint-relevant values of body surface area (BSA) 10, 30, 50, 70 and 90%. PASI and PrecisePASI correlate significantly over the whole range of BSA. In the region of BSA <5%, PrecisePASI shows a significantly higher resolution (p < 0.0001). Conclusion: The calculation of PrecisePASI corrects the undesired inaccuracies of PASI in the lower BSA ranges and is a tool to use as an endpoint in trials aiming to detect differences in the lower ranges of BSA.
There Are Many Ways to See the Forest for the Trees

Abstraction is a useful process for broadening mental horizons, integrating new experiences, and communicating information to others. Much attention has been directed at identifying the causes and consequences of abstraction across the subdisciplines of psychology. Despite this attention, an integrative review of the methods that are used for studying abstraction is missing from the literature. The current article aims to fill this gap in several ways. First, we highlight the different ways in which abstraction has been defined in the literature and then suggest an integrative definition. Second, we provide a tour of the different ways abstraction has been manipulated and measured over the years. Finally, we highlight considerations for researchers in choosing methods for their own research.