Miracle-dz/UniFAR-FTUs huggingface dataset:
The Montreal Cognitive Assessment: Short Cognitive Evaluation in a Large Stroke Trial

Background and Purpose— Cognitive function is often ignored in stroke research trials. The brief Montreal Cognitive Assessment (MoCA) may be sensitive to stroke-related cognitive deficits. Methods— We evaluated the feasibility of administering the MoCA at 3 months in a large stroke trial (A Very Early Rehabilitation Trial [AVERT]). Results— Data (blinded to intervention group) are presented for 294 patients with mean age of 70.6 years (SD, 12.8); 220 (75%) completed the MoCA, 54 (18%) had missing data, and 20 (7%) had died. Of those surviving to 3 months, the MoCA was completed by 87% with mild stroke, 79% with moderate stroke, and 67% with severe stroke on admission. Mean MoCA score was 21.1 (SD 7.5) out of 30; only 78 of 220 (35%) patients attained the “normal” cutoff (≥26). Conclusions— The MoCA is a feasible global cognitive screening tool in stroke trials. Clinical Trial Registration— URL: www.anzctr. org.au/trial_view. aspx? ID=1266. Unique identifier: ACTRN12606000185561.
O3-N2O correlations from the Atmospheric Chemistry Experiment: Revisiting a diagnostic of transport and chemistry in the stratosphere

[1] Our knowledge of stratospheric O3-N2O correlations is extended, and their potential for model-measurement comparison assessed, using data from the Atmospheric Chemistry Experiment (ACE) satellite and the Canadian Middle Atmosphere Model (CMAM). ACE provides the first comprehensive data set for the investigation of interhemispheric, interseasonal, and height-resolved differences of the O3-N2O correlation structure. By subsampling the CMAM data, the representativeness of the ACE data is evaluated. In the middle stratosphere, where the correlations are not compact and therefore mainly reflect the data sampling, joint probability density functions provide a detailed picture of key aspects of transport and mixing, but also trace polar ozone loss. CMAM captures these important features, but exhibits a displacement of the tropical pipe into the Southern Hemisphere (SH). Below about 21 km, the ACE data generally confirm the compactness of the correlations, although chemical ozone loss tends to destroy the compactness during late winter/spring, especially in the SH. This allows a quantitative comparison of the correlation slopes in the lower and lowermost stratosphere (LMS), which exhibit distinct seasonal cycles that reveal the different balances between diabatic descent and horizontal mixing in these two regions in the Northern Hemisphere (NH), reconciling differences found in aircraft measurements, and the strong role of chemical ozone loss in the SH. The seasonal cycles are qualitatively well reproduced by CMAM, although their amplitude is too weak in the NH LMS. The correlation slopes allow a “chemical” definition of the LMS, which is found to vary substantially in vertical extent with season.
Towards learning hierarchical skills for multi-phase manipulation tasks

Most manipulation tasks can be decomposed into a sequence of phases, where the robot's actions have different effects in each phase. The robot can perform actions to transition between phases and, thus, alter the effects of its actions, e.g. grasp an object in order to then lift it. The robot can thus reach a phase that affords the desired manipulation. In this paper, we present an approach for exploiting the phase structure of tasks in order to learn manipulation skills more efficiently. Starting with human demonstrations, the robot learns a probabilistic model of the phases and the phase transitions. The robot then employs model-based reinforcement learning to create a library of motor primitives for transitioning between phases. The learned motor primitives generalize to new situations and tasks. Given this library, the robot uses a value function approach to learn a high-level policy for sequencing the motor primitives. The proposed method was successfully evaluated on a real robot performing a bimanual grasping task.
The unique aspects of the nutrition transition in South Korea: the retention of healthful elements in their traditional diet

Abstract Objective: The purposes of this paper are to describe the unique aspects of the nutrition transition in South Korea, including trends in food consumption and obesity, patterns of morbidity and mortality; to focus on efforts to maintain the traditional diet in the midst of rapid economic growth and the introduction of Western culture; and to provide insights for other countries. Design: We analysed secondary dietary intake, anthropometric, morbidity and mortality datafrom published reports and articles. Results: In South Korea, the level and rate of increase in fat intake have remained very low, whereas vegetable intake has been high and fruit intake has increased greatly. South Kore also has a relatively low prevalence of obesity compared with other Asian countries. The traditional Korean diet is a low-fat and high-vegetable diet. Therefore, the government and nutrition specialists have been initiating numerous efforts to advertise and teach the public that the traditional diet is a healthy diet. They are also working on revival of the traditional dietusing an approach that is acceptable to contemporary Koreans. Conclusions: The nutrition transition in South Korea is unique. A range of government, nutrition specialists and some private organisation efforts has worked to retain healthful elements of the traditional diet in South Korea. The continued low level of total fat in the overalldiet and the high intake of fruits and vegetables bode well for South Korea.
Janus Kinase 2 Modulates the Apolipoprotein Interactions with ABCA1 Required for Removing Cellular Cholesterol*

ATP-binding cassette transporter A1 (ABCA1) mediates transport of cellular cholesterol and phospholipids to high density lipoprotein (HDL) apolipoproteins, such as apoA-I. ABCA1 mutations can cause a severe HDL deficiency and atherosclerosis. Here we show that the protein-tyrosine kinase (TK) Janus kinase 2 (JAK2) modulates the apolipoprotein interactions with ABCA1 required for removing cellular lipids. The protein kinase A (PKA) inhibitor H89, the TK inhibitor genistein, and the JAK2 inhibitor AG490 suppressed apoA-I-mediated cholesterol and phospholipid efflux from ABCA1-expressing cells without altering the membrane ABCA1 content. Whereas PKA inhibition had no effect on apoA-I binding to cells or to ABCA1, TK and JAK2 inhibition greatly reduced these activities. Conversely, PKA but not JAK2 inhibition significantly reduced the intrinsic cholesterol translocase activity of ABCA1. Mutant cells lacking JAK2 had a severely impaired apoA-I-mediated cholesterol and phospholipid efflux and apoA-I binding despite normal ABCA1 protein levels and near normal cholesterol translocase activity. Thus, although PKA modulates ABCA1 lipid transport activity, JAK2 appears to selectively modulate apolipoprotein interactions with ABCA1. TK-mediated phosphorylation of ABCA1 was undetectable, implicating the involvement of another JAK2-targeted protein. Acute incubation of ABCA1-expressing cells with apoA-I had no effect on ABCA1 phosphorylation but stimulated JAK2 autophosphorylation. These results suggest that the interaction of apolipoproteins with ABCA1-expressing cells activates JAK2, which in turn activates a process that enhances apolipoprotein interactions with ABCA1 and lipid removal from cells.
IDENTIFICATION AND CHARACTERIZATION OF GLUCOCORTICOID RECEPTORS IN B 16 MOUSE MELANOMA CELLS

Objective. To gain better insight into the role of glucocorticoids as modulators of cell growth, as well as to investigate the presence and characteristics of glucocorticoid receptors (GR) in mouse melanoma cells. Methods. In two different B16 mouse melanoma cell clones (B16/F10 and B16/C3) the role of synthetic glucocorticoids (triamcinolone acetonide, TA) as cell growth modulators was investigated. Results. The inhibitory effect of TA on B16/F10 cell growth after 8 days in culture was observed. The same hormonal treatment applied on B16/C3 melanoma cells also provoked changes in the cell growth. Dot blot analysis, using monoclonal antirodent glucocorticoid receptor antibodies showed the presence of receptor protein in both cell clones. The analysis of glucocorticoid receptors in B16/F10 and B16/C3 cell cytosol by Scatchard assay and ion-exchange chromatography on DEAE-Sephadex A-50 minicolumn indicated that the changes in melanoma cell growth may be mediated by glucocorticoid receptors and may relieve changes in the GR itself. Conclusions. It was found that B16/C3 melanoma cells exhibited different growth pattern under TA treatment when compared to the results obtained with B16/F10 cells. Such differences may be mediated by glucocorticoid receptors.
Expressed Emotion in Mothers of Currently Depressed, Remitted, High-Risk, and Low-Risk Youth: Links to Child Depression Status and Longitudinal Course

This study examined expressed emotion in the families of children and adolescents who were (a) in a current episode of Major Depressive Disorder (MDD), (b) in remission from a past episode of MDD, (c) at high familial risk for developing MDD, and (d) low-risk controls. Participants were 109 mother–child dyads (children ages 8–19). Expressed emotion was assessed using the Five Minute Speech Sample, and psychiatric follow-ups were conducted annually. Mothers of children with a current or remitted episode of MDD and at high risk for MDD were more likely to be rated high on criticism than mothers of controls. There were no differences in critical expressed emotion among mothers of children in the current, remitted, or high-risk for depression groups. Higher initial critical expressed emotion was associated with a greater likelihood of having a future onset of a depressive episode in high-risk and depressed participants. Diagnostic groups did not differ in Emotional Overinvolvement.
Reduced peripheral activity leading to hepato‐preferential action of basal insulin peglispro compared with insulin glargine in patients with type 1 diabetes

Basal insulin peglispro (BIL), a novel PEGylated basal insulin with a large hydrodynamic size, has a delayed absorption and reduced clearance that prolongs the duration of action. The current study compared the effects of BIL and insulin glargine (GL) on endogenous glucose production (EGP), glucose disposal rate (GDR) and lipolysis in patients with type 1 diabetes.
Measuring Outsourcing Relationship Quality: Towards a Social Network Analysis Approach

Outsourcing initiatives are complex undertakings requiring careful management of the client/vendor relationship. While monitoring the vendor’s performance is a common practice, insight into the status of the ‘soft’ aspects of the relationship, such as trust, is often not available, although research highlights the social aspects as a critical success factor. However, monitoring the softer facets’ quality is difficult: Vendor managers track the status of the soft aspects, if at all, using survey tools among involved staff. This has shortcomings because it does not only capture subjective perceptions, but also interrupts the daily business of the participants. To develop a more objective instrument that collects data without interfering daily business, we draw on social network analysis. We suggest an approach that will eventually allow managers to monitor relationship quality in an efficient and objective way. The results suggest metrics to measure the soft factors of a relationship, such as trust and commitment.
School Aggression and Dispositional Aggression among Middle School Boys

Abstract We examined the relationship between dispositional (trait) aggression and administrative reports of school aggression among 100 adolescent male participants from an urban middle school. Aggression was fairly common among the sample; 58 boys had a record of school aggression, and many of those were repeat offenders. Our hypothesis that those higher in dispositional aggression would have more records of aggression at school was supported. Dispositional aggression was significantly, positively correlated with verbal and physical aggression at school. Regression analyses indicated that dispositional aggression accounted for a substantial amount of the variance in administrative reports of school aggression. Two other factors, family income and age, accounted for a minimal amount of the variance in school aggression.
Effects of Hormone Replacement Therapy on Insulin Resistance and Platelet Function Tests

Objectives: The aim of this study was to evaluate measures of insulin resistance and platelet function in postmenopausal women with oral or transdermal hormone replacement therapy (HRT). Subjects and Methods: Eighty women divided into four groups of 20 each were enrolled in the study. Group 1: postmenopausal hysterectomized women who received only transdermal estradiol (13.9 mg/12.5 cm2); group 2: women with intact uterus who were treated with estrogen-progestin combination (HRT); group 3: postmenopausal women who were treated with the selective estrogen receptor modulator tibolone, and group 4: women who were not taking any drugs for HRT were chosen as a control group (group 4). Results: In group 2, homeostasis model assessment of insulin resistance and fasting insulin levels were 2.90 ± 0.37 and 9.3 ± 3.0 µU/ml, respectively, prior to administration of HRT. These levels were reduced to 1.91 ± 0.41 (p = 0.001) and 7.1 ± 2.7 µU/ml (p = 0.002), respectively, after drug therapy. Mean levels of high-sensitivity C-reactive protein (hsCRP) were decreased with HRT only in group 2 (p = 0.002). No changes for biochemical and hematological parameters were observed in the other groups. Platelet function tests showed no differences after HRT in any group. Conclusions: Estrogen-progestin combination HRT decreased measures of insulin resistance and hsCRP levels, but had no effect on platelet function tests in postmenopausal women.
A primary acoustic startle circuit: lesion and stimulation studies

The latency of the acoustic startle reflex in the rat is 8 msec, measured from tone onset to the beginning of the electromyographic response in the hindleg. This extremely short latency indicates that only a few synapses could be involved in some primary acoustic startle circuit. Acoustic startle is being used as a model system for studying habituation, sensitization, prepulse inhibition, classical conditioning, fear or anxiety, and drug effects on behavior. The present study attempted to delineate a short latency acoustic startle circuit, since this would provide critical information for further study in all of these areas. Bilateral lesions of the ventral cochlear nucleus, which receives the primary auditory input, abolish acoustic startle. Electrical, single pulse stimulation of the ventral cochlear nucleus elicits startle-like responses with a latency of about 7 msec. Bilateral lesions of the dorsal and ventral nuclei of the lateral lemniscus, which receive direct input from the ventral cochlear nuclei, abolish acoustic startle. Electrical stimulation of these nuclei elicits startle-like responses with a latency of about 6 msec. Bilateral lesions of ventral regions of the nucleus reticularis pontis caudalis, which contain cell bodies that give rise to the reticulospinal tract, abolish acoustic startle. Electrical stimulation of these points elicits startle-like responses with a latency of about 5 msec. Reaction product from horseradish peroxidase iontophoresed into this area is found in the nuclei of the lateral lemniscus. In contrast, lesions of the dorsal cochlear nuclei, vestibular nuclei, nucleus reticularis pontis oralis, nucleus reticularis gigantocellularis, and dorsal regions of the nucleus reticularis pontis caudalis fail to abolish acoustic startle. Also, “startle” cannot be elicited electrically from these areas. The data suggest that a primary acoustic startle circuit in the rat consists of auditory nerve, ventral cochlear nucleus, nuclei of the lateral lemniscus, nucleus reticularis pontis caudalis, spinal interneuron, lower motor neuron, and muscles. Hence, five synapses, plus the neuromuscular junction, are probably involved.
Is seeing (musical) believing? The eye versus the ear in emotional responses to music

This study explored whether visual (body movements) or auditory (musical material) information dominates perceived and felt emotions when observing a music performance. In a musical analogue of the McGurk effect and extending work juxtaposing facial expressions and auditory information for sung intervals to an actual musical performance, participants either watched video clips in which musical material and performer’s body movements were congruent or they saw incongruent clips that combined musical material with body movements from another piece that differed in emotional valence. Subsequent ratings of perceived and felt emotions showed a significant interaction between music and body movements, indicating that both auditory and visual channels determine the emotional content of the performance for listeners.
Automatic Detection and Parameter Estimation of Trees for Forest Inventory Applications Using 3D Terrestrial LiDAR

Forest inventory plays an important role in the management and planning of forests. In this study, we present a method for automatic detection and estimation of trees, especially in forest environments using 3D terrestrial LiDAR data. The proposed method does not rely on any predefined tree shape or model. It uses the vertical distribution of the 3D points partitioned in a gridded Digital Elevation Model (DEM) to extract out ground points. The cells of the DEM are then clustered together to form super-clusters representing potential tree objects. The 3D points contained in each of these super-clusters are then classified into trunk and vegetation classes using a super-voxel based segmentation method. Different attributes (such as diameter at breast height, basal area, height and volume) are then estimated at individual tree levels which are then aggregated to generate metrics for forest inventory applications. The method is validated and evaluated on three different data sets obtained from three different types of terrestrial sensors (vehicle-borne, handheld and static) to demonstrate its applicability and feasibility for a wide range of applications. The results are evaluated by comparing the estimated parameters with real field observations/measurements to demonstrate the efficacy of the proposed method. Overall segmentation and classification accuracies greater than 84 % while average parameter estimation error ranging from 1 . 6 to 9 % were observed.
The death receptor pathway is not involved in alloreactive T-cell induced mitochondrial membrane permeability

Elimination of tumor cells by cytotoxic T lymphocytes (CTL) is mediated by two major pathways: the granule exocytosis and the death receptor pathway, transduced by Fas, TNF and TRAIL. The usage of these distinct pathways in the alloreactive setting across major and minor HLA barriers still remains controversial. We generated CTLs against allogeneic Epstein-Barr virus (EBV)-transformed cell lines (LCL) from HLA-unmatched healthy donors and assessed their cytotoxicity by flow cytometrically measuring mitochondrial membrane permeability (MMP) of target cells. Mitochondrial apoptosis induced by CTL was abrogated by selectively inhibiting the granule exocytosis-mediated pathway with Concanamycin A (CMA). Conversely, apoptosis was not decreased in the presence of the caspase 8 inhibitor IETD, which is specific for all death receptor pathways. In general, caspases were not involved in MMP as shown using the pan-caspase inhibitor zVAD. This effector mechanism was preserved when using purified CD4 + and CD8 + T-lymphocyte subsets to generate CTL. We further showed, that death receptor signalling was not used as a salvage mechanism when granule exocytosis was inhibited even at longer incubation times sufficient for slow kinetic death receptor caspase signalling. Our results clearly demonstrate that mitochondrial apoptosis induced by human alloreactive CTLs is mainly mediated by granule exocytosis but not by death receptor caspase dependent pathways. Furthermore, the granule exocytosis pathway does not require caspases to induce MMP.
Design of an optimized charge-blended energy management strategy for a plugin hybrid vehicle

This paper introduces the design of a charge blended energy management control system for use within a plugin hybrid electric vehicle. The approach taken extends the local cost function optimization routine associated with an Equivalent Fuel Consumption Method (EFCM) in which the charge-sustaining penalty factor is calculated online from an integrated PI controller rather than being derived from a pre-calibrated lookup table. The performance of the controller for a hybrid vehicle exercised over a number of different drive-cycles is presented. The powertrain model used to design and evaluate the system is derived from data logged onboard a number of different electric vehicles under real-world driving conditions.
Motion Analysis of Soft-Fingertip Manipulation Tasks

This paper provides a motion analysis of soft-fingertip object manipulation tasks by presenting a dynamic model of multi-fingered object manipulations with soft fingertips. It is fun- damentally observed that soft fingertips employed in a multi-fingered hand generate some defor- mation effects during the manipulation process and also that those effects are closely related to the behavior of the manipulated object. In order to analyze the motion of using soft fingertips, a dy- namic manipulation control scheme is presented. Simulation and experimental results demonstrate the motion of soft-fingertips applied in object manipulating tasks and are further used to discuss the characteristics of soft-fingertip motions.
Management of Dually Active Chronic Hepatitis B (HBV) and Hepatitis C Virus (HCV) Co-Infection: Case Report

ABSTRACT We report the case of a 60 year old gentleman referred for management of dually active chronic hepatitis B (HBV) and C (HCV) co-infection. Initial treatment with Pegylated Interferon and Ribavirin was marked by early virological response for HCV as from week 12 with sustained high virological response to the end of treatment at week 48. There was however a non-response of the HBV to this peg interferon and Ribavirin and the introduction of a nucleoside analogue (Tenofovir) at the end of Peg interferon Ribavirin treatment at week 48 resulted in remarkable HBV suppression to undetectable HBV-DNA levels. While this case report demonstrates that HBV/HCV co-infection can be satisfactorily treated in our setting, the high prevalence of both viral infections in Cameroon, the high cost of management and the unavailability of appropriate drugs warrants the Ministry of Public Health to take the lead in implementing adequate preventive and therapeutic strategies so as to reduce morbidity and mortality of liver diseases associated with these infections.