Miracle-dz/UniFAR-FTUs huggingface dataset:
Spanish-language services assessment for children and adolescents (SACA): reliability of parent and adolescent reports.

OBJECTIVE To assess test-retest reliability of the service utilization screening section of the Services Assessment for Children and Adolescents (SACA) interview among Spanish-speaking parents and adolescents, correspondence between parent and adolescent reports, and the correlation between reliability and participants' demographic and service use characteristics. METHOD The English SACA was translated and administered from September 1999 through January 2000 in Los Angeles County, California, on two separate occasions to eligible parents with a child (4-17 years old) who was a client of a local public mental health authority. Adolescents of these parents (12-17 years old) were also interviewed. Reliability was measured by the kappa statistic. RESULTS Adult and adolescent reports about lifetime and previous year service setting use exhibited good reliability, but concordance of parents and adolescents did not. Children's service utilization appears to be correlated with reliability of parent reports, and child gender appears to be correlated with reliability of adolescent reports. CONCLUSION The SACA appears to be a useful tool for screening Spanish-speaking families about child and adolescent mental health service use. These findings must be considered preliminary until replicated in a larger sample of culturally diverse Spanish-speaking families.
Predictive analysis and optimisation of pipelined wavefront applications using reusable analytic models

Pipelined wavefront computations are an ubiquitous class of high performance parallel algorithms used for the solution of many scientific and engineering applications. In order to aid the design and optimisation of these applications, and to ensure that during procurement platforms are chosen best suited to these codes, there has been considerable research in analysing and evaluating their operational performance. Wavefront codes exhibit complex computation, communication, synchronisation patterns, and as a result there exist a large variety of such codes and possible optimisations. The problem is compounded by each new generation of high performance computing system, which has often introduced a previously unexplored architectural trait, requiring previous performance models to be rewritten and reevaluated. In this thesis, we address the performance modelling and optimisation of this class of application, as a whole. This differs from previous studies in which bespoke models are applied to specific applications. The analytic performance models are generalised and reusable, and we demonstrate their application to the predictive analysis and optimisation of pipelined wavefront computations running on modern high performance computing systems. The performance model is based on the LogGP parameterisation, and uses a small number of input parameters to specify the particular behaviour of most wavefront codes. The new parameters and model equations capture the key structural and behavioural differences among different wavefront application codes, providing a succinct summary of the operations for each application and insights into alternative wavefront application design. The models are applied to three industry-strength wavefront codes and are validated on several systems including a Cray XT3/XT4 and an InfiniBand commodity cluster. Model predictions show high quantitative accuracy (less than 20% error) for all high performance configurations and excellent qualitative accuracy. The thesis presents applications, projections and insights for optimisations using the model, which show the utility of reusable analytic models for performance engineering of high performance computing codes. In particular, we demonstrate the use of the model for: (1) evaluating application configuration and resulting performance; (2) evaluating hardware platform issues including platform sizing, configuration; (3) exploring hardware platform design alternatives and system procurement and, (4) considering possible code and algorithmic optimisations.
A Fully Embedded 60-GHz Novel BPF for LTCC System-in-Package Applications

In this paper, a novel LTCC stripline (SL) 60-GHz band-pass filter (BPF) composed of transitions to coplanar waveguide (CPW) pads for monolithic microwave integrated circuit integration is presented. For low-loss interconnection with active devices, a CPW-to-SL vertical via transition integrating air cavities and a CPW-to-CPW planar transition using internal ground planes are proposed and implemented. The fabricated transition shows an insertion loss of 1.6 dB and a reflection loss below -20 dB at the passband of the filter. The implemented SL BPF using dual-mode patch resonators shows a center frequency of 60.4 GHz, 3.5 % bandwidth, and reflection losses below -15 dB at the passband. Excluding the insertion loss of the transitions, the filter insertion loss reveals 4.0 dB
Active research towards the addressal of HIV/AIDS in the informal economy in Zambia

In this article we offer an account of research undertaken for the International Labour Organization (on behalf of the National Aids Council in Zambia) in relation to HIV/AIDS and the informal economy in Zambia. We concentrate on how we tried to operate in terms of a conscious recognition of (and acceptance of responsibility for) our complicity as inquirers (together with others) in the development of the unfolding situations being explored. We indicate why we define as `active research' the approach adopted, and how we see this as related to the broader category of `action research'. We suggest that this kind of approach may be helpful for others wishing to engage in development programmes broadly understood and intended to support people's efforts to develop viable ways of knowing-and-living.
The Effect of MicroRNA-375 Overexpression, an Inhibitor of Helicobacter pylori-Induced Carcinogenesis, on lncRNA SOX2OT

Background Helicobacter pylori is a major human pathogenic bacterium in gastric mucosa. Although the association between gastric cancer and H. pylori has been well-established, the molecular mechanisms underlying H. pylori-induced carcinogenesis are still under investigation. MicroRNAs (miRNAs) are small noncoding RNAs that modulate gene expression at the posttranscriptional level. Recently, studies have revealed that miRNAs are involved in immune response and host cell response to bacteria. Also, microRNA-375 (miR-375) is a key regulator of epithelial properties that are necessary for securing epithelium-immune system cross-talk. It has been recently reported that miR-375 acts as an inhibitor of H. pylori-induced gastric carcinogenesis. There are few reports on miRNA-mediated targeting long noncoding RNAs (lncRNAs). Objectives This study aimed to examine the possible effect of miR-375 as an inhibitor of H. pylori-induced carcinogenesis on the expression of lncRNA SOX2 overlapping transcript (SOX2OT) and SOX2, a master regulator of pluripotency of cancer stem cells. Materials and Methods In a model cell line, NT-2 was transfected with the constructed expression vector pEGFP-C1 contained miR-375. The RNA isolations and cDNA synthesis were performed after 48 hours of transformation. Expression of miR-375 and SOX2OT and SOX2 were quantified using real-time polymerase chain reaction and compared with control cells transfected with pEGFP-C1-Mock clone. Cell cycle modification was also compared after transfections using the flow cytometry analysis. Results Following ectopic expression of miR-375, SOX2OT and SOX2 expression analysis revealed a significant decrease in their expression level (P < 0.05) in NT-2 cells compared to the control. Cell cycle analysis following ectopic expression of miR-375 in the NT-2 cells using propidium iodine staining revealed significant extension in sub-G1 cell cycle. Conclusions This is the first report to show down-regulation of SOX2OT and SOX2 following induced expression of miR-375. This finding may suggest expression regulation potential between different classes of ncRNAs, for example between miR-375 and SOX2OT. This data not only extends our understanding of possible ncRNA interactions in cancers but also may open novel investigation lines towards elucidation of molecular mechanisms controlling H. pylori inflammation and carcinogenesis.
Achieving Consensus Across Diverse Stakeholders on Quality Measures for Mental Healthcare

Objective:Quality-improvement efforts are hindered by a lack of consensus on meaningful and feasible measures of care. The objective of this study was to develop a core set of quality measures for mental health and substance-related care that are meaningful to stakeholders, feasible to implement, and broadly representative of diverse dimensions of the mental health system. Method:A 12-member panel of stakeholders from national organizations evaluated 116 process measures in a 2-stage modified Delphi consensus development process. Drawing on a conceptual framework and literature review, panelists rated each measure on 7 domains using a 9-point scale (1 = best). Measures were then mapped to a framework of system dimensions to identify a core set with the highest ratings for system characteristics within each dimension. Results:Twenty-eight measures were identified assessing treatment (12), access (2), assessment (2), continuity (4), coordination (2), prevention (1), and safety (5). Overall, mean ratings for meaningfulness were: clinical importance 2.29; perceived gap between actual and optimal care 2.59; association between improved performance and outcome 2.61. For feasibility, mean ratings were clarity of specifications 3.39; acceptability of data collection burden 4.77; and adequacy of case mix adjustment 4.20. The measures address a range of treatment modalities, clinical settings, diagnostic categories, vulnerable populations, and other dimensions of mental healthcare. Conclusions:A structured consensus process identified a core set of quality measures that are meaningful and feasible to multiple stakeholders, as well as broadly representative of the mental healthcare system. By yielding quantitative assessments of meaningfulness, feasibility and degree of consensus among stakeholders, these results can inform ongoing national efforts to adopt common quality measures for mental healthcare.
Regulation of Cdc42 polarization by the Rsr1 GTPase and Rga1, a Cdc42 GTPase-activating protein, in budding yeast

ABSTRACT Cdc42 plays a central role in establishing polarity in yeast and animals, yet how polarization of Cdc42 is achieved in response to spatial cues is poorly understood. Using live-cell imaging, we found distinct dynamics of Cdc42 polarization in haploid budding yeast in correlation with two temporal steps of the G1 phase. The position at which the Cdc42–GTP cluster develops changes rapidly around the division site during the first step but becomes stabilized in the second step, suggesting that an axis of polarized growth is determined in mid G1. Cdc42 polarization in the first step and its proper positioning depend on Rsr1 and its GTPase-activating protein (GAP) Bud2. Interestingly, Rga1, a Cdc42 GAP, exhibits transient localization to a site near the bud neck and to the division site during cytokinesis and G1, and this temporal change of Rga1 distribution is necessary for determination of a proper growth site. Mathematical modeling suggests that a proper axis of Cdc42 polarization in haploid cells might be established through a biphasic mechanism involving sequential positive feedback and transient negative feedback.
Decrease of Oscillator Phase Noise and I/Q Imbalance impacts on a WLAN transmitter using appropriate predistortion

This paper presents the oscillator phase noise and I/Q imbalance impacts on a dual band transmitter and how predistortion can be used in order to improve its performance. At the beginning, the oscillator phase noise and I/Q imbalance are dealt with as unavoidable phenomena in wireless networks, and then the description of the way they are modeled follows. The test-bench setup that was used for the performance analysis is then described and, finally, simulation results are presented for the various examined cases, where it is demonstrated that appropriate predistortion can simultaneously decrease power amplifier's non-linearities, oscillator phase noise and I/Q imbalance impacts.
Molecular dynamics of the frame-shifting pseudoknot from beet western yellows virus: the role of non-Watson-Crick base-pairing, ordered hydration, cation binding and base mutations on stability and unfolding.

Molecular dynamics simulations of the frame-shifting pseudoknot from beet western yellows virus (BWYV, NDB file UR0004) were performed with explicit inclusion of solvent and counterions. In all, 33 ns of simulation were carried out, including 10 ns of the native structure with protonation of the crucial cytosine residue, C8(N3+). The native structure exhibited stable trajectories retaining all Watson-Crick and tertiary base-pairs, except for fluctuations or transient disruptions at specific sites. The most significant fluctuations involved the change or disruption of hydrogen-bonding between C8(N3+) and bases G12, A25, and C26, as well as disruption of the water bridges linking C8(N3+) with A25 and C26. To increase sampling of rare events, the native simulation was continued at 400 K. A partial, irreversible unfolding of the molecule was initiated by slippage of C8(N3+) relative to G12 and continued by sudden concerted changes in hydrogen-bonding involving A23, A24, and A25. These events were followed by a gradual loss of stacking interactions in loop 2. Of the Watson-Crick base-pairs, only the 5'-terminal pair of stem 1 dissociated at 400 K, while the trans sugar-edge/sugar-edge A20.G4 interaction remained surprisingly stable. Four additional room-temperature simulations were carried out to obtain insights into the structural and dynamic effects of selected mutations. In two of these, C8 was left unprotonated. Considerable local rearrangements occurred that were not observed in the crystal structure, thus confirming N3-protonation of C8 in the native molecule. We also investigated the effect of mutating C8(N3+) to U8, to correlate with experimental and phylogenetic studies, and of changing the G4 x C17 base-pair to A4 x U17 to weaken the trans sugar-edge interaction between positions 4 and 20 and to test models of unfolding. The simulations indicate that the C8 x G12 x C26 base-triple at the junction is the most labile region of the frame-shifting pseudoknot. They provide insights into the roles of the other non-Watson-Crick base-pairs in the early stages of unfolding of the pseudoknot, which must occur to allow readthrough of the message by the ribosome. The simulations revealed several critical, highly ordered hydration sites with close to 100 % occupancies and residency times of individual water molecules of up to 5 ns. Sodium cation coordination sites with occupancies above 50 % were also observed.
Shallow Parsing Pipeline - Hindi-English Code-Mixed Social Media Text

In this study, the problem of shallow parsing of Hindi-English code-mixed social media text (CSMT) has been addressed. We have annotated the data, developed a language identifier, a normalizer, a part-of-speech tagger and a shallow parser. To the best of our knowledge, we are the first to attempt shallow parsing on CSMT. The pipeline developed has been made available to the research community with the goal of enabling better text analysis of Hindi English CSMT. The pipeline is accessible at 1.
Roles for thromboxane A 2 and leukotrienes in endotoxin — induced acute renal failure

Roles for thromboxane A2 and leukotrienes in endotoxin—induced acute renal failure. Bolus iv. administration of 100 j.g/kg of E. Co/i lipopolysaccharide endotoxin (LPS) to adult male Munich—Wistar rats (N = 18) resulted in a progressive fall in RBF and GFR from 6.9 0.2 SE and I. 0.05 mI/mm to minimal values at 50 minutes of 3.8 0.4 and 0.32 0.08 (P < 0.05), respectively, without a fall in mean arterial pressure. At 50 minutes, renal cortical generation rates of PGE2 (1075 108 pg/mg tissue), 6 keto PGF1 (221 41 pg/mg), and TxB2 (106 12 pg/mg) were significantly higher than those of vehicle—treated control rats (N = 10, PGE2 = 466 107, 6 keto PGFIC, = 94 3, and TxB2 = 35 3 pg/mg), and morphologic examination revealed normal histology with notable absence of leukocytes and platelets. Pretreatment of a third group of nine rats with TxA2 synthetase inhibitor UK-37.248 (dazoxiben, 10 mg/kg) selectively abolished the LPS-induced rise in TxB2 (29 3 pg/mg), but not PGE2 (837 62 pg/mg) or 6 keto PGF1, (179 5 pg/mg), prevented the fall in RBF at 50 minutes (6.3 0.4 mI/mm), and allowed for significant preservation of GFR (0.67 0.08 mI/mm). In addition, antagonism of endogenously produced LTs with the putative receptor antagonist FPL55712 (N = 10, 500 pg/kg/mm x 40 mm), while not preventing the LPS-induced rise in TxB2 generation rate (97 pg/mg); significantly ameliorated the fall in RBF at 50 minutes (5.9 0.5 mI/mm), whereas GFR was depressed (0.46 0.13 mI/mm), but recovered to 0.57 0.08 mI/mm at 70 mm post-LPS (P < 0.05 vs. LPS alone). These observations point to major roles for TxA2 and sulfidopeptide LTs in mediating the renal functional impairment of experimental endotoxemia.
Phosphorylation, glycosylation, and proteolytic activity of the 52-kD estrogen-induced protein secreted by MCF7 cells

We have studied the posttranslational modifications of the 52-kD protein, an estrogen-regulated autocrine mitogen secreted by several human breast cancer cells in culture (Westley, B., and H. Rochefort, 1980, Cell, 20:353-362). The secreted 52-kD protein was found to be phosphorylated mostly (94%) on high-mannose N-linked oligosaccharide chains, and mannose-6-phosphate signals were identified. The phosphate signal was totally removed by alkaline phosphatase hydrolysis. The secreted 52-kD protein was partly taken up by MCF7 cells via mannose-6- phosphate receptors and processed into 48- and 34-kD protein moieties as with lysosomal hydrolases. By electron microscopy, immunoperoxidase staining revealed most of the reactive proteins in lysosomes. After complete purification by immunoaffinity chromatography, we identified both the secreted 52-kD protein and its processed cellular forms as aspartic and acidic proteinases specifically inhibited by pepstatin. The 52-kD protease is secreted in breast cancer cells under its inactive proenzyme form, which can be autoactivated at acidic pH with a slight decrease of molecular mass. The enzyme of breast cancer cells, when compared with cathepsin D(s) of normal tissue, was found to be similar in molecular weight, enzymatic activities (inhibitors, substrates, specific activities), and immunoreactivity. However, the 52- kD protein and its cellular processed forms of breast cancer cells were totally sensitive to endo-beta-N-acetylglucosaminidase H (Endo H), whereas several cellular cathepsin D(s) of normal tissue were partially Endo H-resistant. This difference, in addition to others concerning tissue distribution, mitogenic activity and hormonal regulation, strongly suggests that the 52-kD cathepsin D-like enzyme of breast cancer cells is different from previously described cathepsin D(s). The 52-kD estrogen-induced lysosomal proteinase may have important functions in facilitating the mammary cancer cells to proliferate, migrate, and metastasize.
NMR-Based Multi Parametric Quality Control of Fruit Juices: SGF Profiling

With SGF Profiling™ we introduce an NMR-based screening method for the quality control of fruit juices. This method has been developed in a joint effort by Bruker BioSpin GmbH and SGF International e.V. The system is fully automated with respect to sample transfer, measurement, data analysis and reporting and is set up on an Avance 400 MHz flow-injection NMR spectrometer. For each fruit juice a multitude of parameters related to quality and authenticity are evaluated simultaneously from a single data set acquired within a few minutes. This multimarker/multi-aspect NMR screening approach features low cost-per-sample and is highly competitive with conventional and targeted fruit juice quality control methods.
Laser–plasma accelerator: status and perspectives

Laser–plasma accelerators deliver high-charge quasi-monoenergetic electron beams with properties of interest for many applications. Their angular divergence, limited to a few mrad, permits one to generate a small γ ray source for dense matter radiography, whereas their duration (few tens of fs) permits studies of major importance in the context of fast chemistry for example. In addition, injecting these electron beams into a longer plasma wave structure will extend their energy to the GeV range. A GeV laser-based accelerator scheme is presented; it consists of the acceleration of this electron beam into relativistic plasma waves driven by a laser. This compact approach (centimetres scale for the plasma, and tens of meters for the whole facility) will allow a miniaturization and cost reduction of future accelerators and derived X-ray free electron laser (XFEL) sources.
Integrated Current Detector for High Voltage Power Switches Using LDMOS Transistors

An integrated current detector designed to protect high voltage LDMOS power switches is presented in this paper. The proposed detector monitors the current of power switches by a mirrored ratio current. Power switches can be automatically turned off once the mirrored current exceeds the predetermined triggered value and thereby protect power switches from being damages. The response time of current detector determines the maximum operation frequency of the driving signal to the power switch. Both simulated and measurement results show that the designed current detector with an integrated LDMOS switch can work higher than 1 MHz switching frequency with maximum 1A current driving capability.
CYFRA 21-1 as a tool for distant metastasis detection in lung cancer.

BACKGROUND A study to analyse tumor markers (CEA, CA125, CA15.3, CA19.9, CYFRA 21-1, and NSE) for metastasis detection in lung cancer patients. METHODS Serum tumor markers from 73 lung cancer patients were measured before they were diagnosed. After lung cancer diagnosis, tumor markers were analyzed for the detection of distant metastases. RESULTS In NSCLC patients CYFRA 21-1 and NSE showed differences between stage IV and any of the other stages, p < 0.05. The accuracy for metastasis detection was AUC = 81.5 % for CYFRA 21-1 and AUC = 78.6 % for < 0.05) were independent predictors for metastasis presence. No tumor marker showed significant differences according to stages in SCLC patients. CONCLUSIONS CYFRA 21-1 could be used as a screening tool for metastasis detection in lung cancer patients without symptoms of metastasis as well as CYFRA 21-1 and NSE in NSCLC patients.