Miracle-dz/UniFAR-FTUs huggingface dataset:
Systems of interdependency and core orchestrating themes at health care unit level

Abstract Configuration is an appealing concept to help understanding the complex arrangements that guide organizations' actions and contribute to their coherence. Although health care organizations are often described as professional bureaucracy a deep understanding of their structure and systems is still lacking. In this article, we draw on empirical data gathered in a Canadian teaching hospital to expose the nature of interdependencies and themes that drive some of its configurations at health care unit level. Five clinical activities were investigated (ocular surgery, brachytherapy, vascular surgery, rheumatology and geriatrics) using direct systematic observation. Four sub-orchestrating themes emerged. Based on the findings it is argued that the operating core of health care organizations is not homogeneous but rather heterogeneous. Therefore it is our contention that hospitals and other public organizations where professionals control the activities at operating level might be better regarded as ‘diversified professional federation’ than as professional bureaucracy.
Improving spectral‐based fault localization using static analysis

Debugging is crucial for producing reliable software. One of the effective bug localization techniques is spectral‐based fault localization (SBFL). It helps to locate a buggy statement by applying an evaluation metric to program spectra and ranking program components on the basis of the score it computes. SBFL is an example of a dynamic analysis – an analysis of computer program that is performed by executing it with sufficient number of test cases. Static analysis, on the other hand, is performed in a non‐runtime environment. We introduce a weighting technique by combining these two kinds of program analysis. Static analysis is performed to categorize program statements into different classes and giving them weights based on the likelihood of being buggy statement. Statements are finally ranked on the basis of the weights computed by statements' categorization (static analysis) and scores computed by SBFL metrics (dynamic analysis). We evaluate the performance of our technique on Siemens test suite and Flex (having seeded bugs seeded by expert developers), Sed (having mixture of real and seeded bugs), and Space (having real bugs). In our evaluation, proposed weighting technique improves the performance of a wide variety of fault localization metrics up to 20% on single bug datasets and up to 42% on multi‐bug datasets. Copyright © 2017 John Wiley & Sons, Ltd.
Good guanxi and bad guanxi: Western bankers and the role of network practices in institutional change in China

There is an assumption in some neo-institutional theories of organization that China's integration into the global economy will inevitably lead to a reduction in the influence of guanxi on business practices. Drawing on in-depth qualitative interviews, the study shows that while the network practices of many Western managers may contribute to the adoption of international business norms in China, there is another group of managers who make significant adjustments to local conditions and, contrary to the assumptions of neo-institutional theory, actually engage in strategies, which reinforce some of the existing evasive practices sometimes associated with guanxi. This dichotomy is guided by a process of ‘bricolage’, where managers creatively re-interpret the norms of the local context to justify their actions. This observation tempers the proposition that the influence of guanxi will decrease as China moves closer to a form of rational-bureaucratic labour market organization and human resource management. It is argued that the ‘discourse’, which expatriate managers developed around guanxi, is an example of organizational myth-making which is, in itself, an important part of the process of bricolage. It is important therefore not to overlook the role which external forces, such as expatriate managers, can play in re-defining the role of guanxi in China's urban economy.
Leadership performance in TQM: a contingency approach

Purpose – The objective is to describe and conceptualize leadership performance in total quality management (TQM). Design/methodology/approach – A contingency approach to leadership performance in TQM is undertaken.Findings – Contingency models of leadership performance in TQM are introduced. Principal parameters in these models are timely contextual accuracies – as well as they contain foresight versus improvidence accuracies – of TQM. A contingency process of leadership performance accuracy in TQM is also introduced. The accuracy parameters are linked by a process accuracy zone. It serves as a descriptive tool of leadership performance. Finally, a typology of leadership performances in TQM is conceptualised.Research limitations/implications – Generally, this paper is restricted to the core values of TQM, in which a set of core values unites the descriptions of TQM. In particular, this paper is limited to the core value of leadership/management commitment. An important area of further research is to exami.
Hematopoietic Stem Cell Transplantation in an Infant with Immunodeficiency, Centromeric Instability, and Facial Anomaly Syndrome

Immunodeficiency, centromeric instability, and facial anomaly (ICF) syndrome is a rare autosomal recessive genetic condition with severe immunodeficiency, which leads to lethal infections if not recognized and treated in early childhood. Up-to-date treatment regimens consist of prophylactic and supportive treatment of the recurrent infections. Here, we report the case of a 1-year-old boy of Moroccan consanguineous parents, who was diagnosed at 4 months of age with ICF syndrome with a homozygous missense mutation in the DNMT3B gene. He was initially admitted to the hospital with recurrent pulmonary infections from the opportunistic pathogen Pneumocystis jirovecii (PJ). Further immunological workup revealed agammaglobulinemia in the presence of B cells. After successful recovery from the PJ pneumonia, he underwent hematopoietic stem cell transplantation (HSCT) from the HLA-matched healthy sister using a chemotherapeutic conditioning regimen consisting of treosulfan, fludarabine, and thiotepa. Other than acute chemotherapy-associated side effects, no serious adverse events occurred. Six months after HSCT immune-reconstitution, he had a stable chimerism with 2.9% autologous portion in the peripheral blood and a normal differential blood cell count, including all immunoglobulin subtypes. This is one of the first cases of successful HSCT in ICF syndrome. Early diagnosis and subsequent HSCT can prevent severe opportunistic infections and cure the immunodeficiency. Centromeric instability and facial anomaly remain unaffected. Although the long-term patient outcome and the neurological development remain to be seen, this curative therapy for immunodeficiency improves life expectancy and quality of life. This case is meant to raise physicians awareness for ICF syndrome and highlight the consideration for HSCT in ICF syndrome early on.
Foreign direct investment and competitiveness in transition economies: the case of Croatia

The aim of this paper is to address the issues of foreign direct investment (FDI) and to give a comparative analysis of its impact on Croatian competitiveness. Our findings show that in the case of Croatia, unlike in the other transition economies, the majority of inflows of foreign capital is concentrated in the service sector. Also, the impact on the overall Croatian competitiveness level has not been significant. High labour costs and production of low value addition in manufacturing were the main reasons why foreign capital sought mostly service sectors, such as telecommunications and banking, which are oriented towards the domestic markets. This did not contribute towards improving the Croatian export competitiveness either. Other transition economies in Central and Eastern Europe, where FDI went to manufacturing, particularly to the export oriented sectors, as well as to services, recorded a noticeable raise in their competitiveness levels.
Different Hormonal Regulation of Cellular Differentiation and Function in Nucellar Projection and Endosperm Transfer Cells: A Microdissection-Based Transcriptome Study of Young Barley Grains1[W]

Nucellar projection (NP) and endosperm transfer cells (ETC) are essential tissues in growing barley (Hordeum vulgare) grains, responsible for nutrient transfer from maternal to filial tissues, endosperm/embryo nutrition, and grain development. A laser microdissection pressure catapulting-based transcriptome analysis was established to study NP and ETC separately using a barley 12K macroarray. A major challenge was to isolate high-quality mRNA from preembedded, fixed tissue while maintaining tissue integrity. We show that probes generated from fixed and embedded tissue sections represent largely the transcriptome (>70%) of nonchemically treated and nonamplified references. In NP, the top-down gradient of cellular differentiation is reflected by the expression of C3HC4-type ubiquitin ligases and different histone genes, cell wall biosynthesis and expansin/extensin genes, as well as genes involved in programmed cell death-related proteolysis coupled to nitrogen remobilization, indicating distinct areas simultaneously undergoing mitosis, cell elongation, and disintegration. Activated gene expression related to gibberellin synthesis and function suggests a regulatory role for gibberellins in establishment of the differentiation gradient. Up-regulation of plasmalemma-intrinsic protein and tonoplast-intrinsic protein genes indicates involvement in nutrient transfer and/or unloading. In ETC, AP2/EREBP-like transcription factors and ethylene functions are transcriptionally activated, a response possibly coupled to activated defense mechanisms. Transcriptional activation of nucleotide sugar metabolism may be attributed to ascorbate synthesis and/or cell wall biosynthesis. These processes are potentially controlled by trehalose-6-P synthase/phosphatase, as suggested by expression of their respective genes. Up-regulation of amino acid permeases in ETC indicates important roles in active nutrient uptake from the apoplastic space into the endosperm.
Sex-Specific Association Between Nerve Growth Factor Polymorphism and Cardiac Vagal Modulation

Objective Substantial research has shown that anxiety disorders are associated with decreased cardiac vagal tone, which is a known risk factor for cardiac vulnerability. A functional nerve growth factor (NGF) polymorphism (rs6330, c.104C > T, p.Ala35Val) has been associated with anxiety such that in males but not females, T-allele carriers exhibit higher levels of trait anxiety. Here we investigate whether the nonsynonymous NGF variant has an effect on cardiac autonomic control. Methods From 705 adults initially screened for medical and psychiatric illnesses, a final cohort of 580 healthy Han Chinese (352 men, 228 women; mean [standard deviation] age = 34.46 [8.45] years) was included in the NGF genotyping (C/C: 428% [73.8%] and T-allele carriers: 152% [26.2%]). Short-term heart rate variability was used to assess cardiac autonomic function. Results There were significant genotype-by-sex interaction effects (p < .05) on high-frequency power (HF) and root mean square of successive heartbeat interval differences (RMSSD), both indices of cardiac vagal control. Even after adjusting for possible confounders, men with any T allele showed lower HF and RMSSD compared with men with the C/C genotype. Women, however, showed an opposite but nonsignificant pattern. Conclusions The studied NGF polymorphism modulates autonomic outflow to the heart in a sex-dependent manner. The findings support the view that male T-allele carriers are at increased susceptibility for anxiety by association with low vagal activity and suggest a potential sex-specific genetic link between the highly comorbid anxiety disorders and cardiovascular diseases.
DEMAND FORECASTS AND DEMAND ELASTICITIES FOR AUSTRALIAN TRANSPORT FUEL: REPORT.

The Bureau of Transport and Communications Economics commissioned the Transport Research Centre at Macquarie University to investigate various fuel demand forecasts for the transport sector, and in particular to identify the role of fuel prices in current forecasts. The Transport Research Centre also examined the likely effects of alternative fuel pricing strategies on the overall demand for transport fuel, based on estimates of the long-term elasticities of fuel consumption with respect to fuel price. The study focuses on the current major transport fuels, which in 1988-89 accounted for 93 per cent of Australia's transport sector energy consumption: petrol (leaded and unleaded), automotive diesel oil, fuel oil and aviation turbine fuel. Major demand forecasts examined include those of the Australian Bureau of Agricultural and Resource Economics, the National Institute of Economic and Industry Research and the Australian Institute of Petroleum, based on forecasts by oil companies, to the year 2000. From an examination of these forecasts and derived own-price elasticities, the study concludes that only relatively large increases in fuel prices are likely to produce anything more than non-marginal reductions in the levels of fuel demand (a).
Porous Silica-Coated Gold Nanorods: A Highly Active Catalyst for the Reduction of 4-Nitrophenol.

The successful coating of thin porous silica layers of various thicknesses [(10±1), (12±1), and (14±1) nm] on cetyl trimethylammonium bromide (CTAB) capped gold nanorods was achieved through a modified Stöber procedure. The resulting material was applied as a novel catalyst for the reduction of 4-nitrophenol. The catalytic activities of the gold nanorods increased up to eight times after coating with a layer of porous silica and the reaction followed a zero-order kinetics, having a rate constant as high as 2.92×10(-1) mol L(-1) min(-1). The spectral changes during the reduction reaction of 4-nitrophenol were observed within a very short span of time and a complete conversion to 4-aminophenol occured within 5-6 mins, including the induction period of ≈2 mins. The reusability of the catalyst was studied by running the catalytic reaction during five consecutive cycles with good efficiency without destroying the nanostructure. The methodology can be effectively applied to the development of composite catalysts with highly enhanced catalytic activity.
Physical activity and not sedentary time per se influences on clustered metabolic risk in elderly community-dwelling women

Introduction Whether amount of time spent in sedentary activities influences on clustered metabolic risk in elderly, and to what extent such an influence is independent of physical activity behavior, remain unclear. Therefore, the aim of the study was to examine cross-sectional associations of objectively assessed physical activity and sedentary behavior on metabolic risk outcomes in a sample of elderly community-dwelling women. Methods Metabolic risk outcomes including waist circumference, systolic and diastolic blood pressures, fasting levels of plasma glucose, HDL-cholesterol and triglycerides were assessed in 120 community-dwelling older women (65–70 yrs). Accelerometers were used to retrieve daily sedentary time, breaks in sedentary time, daily time in light (LPA) and moderate-to-vigorous physical activity (MVPA), and total amount of accelerometer counts. Multivariate regression models were used to examine influence of physical activity and sedentary behavior on metabolic risk outcomes including a clustered metabolic risk score. Results When based on isotemporal substitution modeling, replacement of a 10-min time block of MVPA with a corresponding time block of either LPA or sedentary activities was associated with an increase in clustered metabolic risk score (β = 0.06 to 0.08, p < 0.05), and an increase in waist circumference (β = 1.78 to 2.19 p < 0.01). All associations indicated between sedentary time and metabolic risk outcomes were lost once variation in total accelerometer counts was adjusted for. Conclusions Detrimental influence of a sedentary lifestyle on metabolic health is likely explained by variations in amounts of physical activity rather than amount of sedentary time per se. Given our findings, increased amounts of physical activity with an emphasis on increased time in MVPA should be recommended in order to promote a favorable metabolic health profile in older women.
Application of Kernel Estimation in Analysis of Labour Productivity of the Largest Polish Firms in 2004-2008

Application of Kernel Estimation in Analysis of Labour Productivity of the Largest Polish Firms in 2004-2008 The parametric methods of statistical and econometric analysis are not always useful in examination of labour productivity of economic entities. In previous works the Authors found that the labour productivity is characterized by the lack of stable regularities in the range of structure and interdependency. In that case it is possible to apply non-parametric methods. In the paper the Authors tried to model the distributions of the labour productivity in time by means of kernel estimation using classical approaches (Epanechnikov, Rosenblatt) and the new proposition called kernel B. It seems that proposed approach is a useful merger of the statistical modeling theory and economic practice which allows to analyze the changes in the labour productivity - the essential factor for long-term economic growth and the welfare of society. The empirical results show that the labour productivity in the largest Polish companies had increased in 2004-2008 but the growths had not the same dynamics in different economic sectors.
Love Thy Neighbor: Trade, Migration and Social Capital

Standard trade theory suggests indifference between free trade and free migration as both lead to factor price equalization. Rich countries, however, prefer free trade to free migration. This inconsistency can be explained by incorporating the impact of social capital. The movement of people differs from the movement of goods and services because people create attachments with those with whom they share social capital, including norms, language, customs, values and culture. South-North migration affects social capital in both places. Four types of externalities associated with migration are identified. The paper develops a parsimonious model and examines the impact of trade and migration policy (and changes in migration costs) under alternative assumptions about the internalization of these externalities. Irrespective of the degree of internalization of externalities, the South gains from trade liberalization and from preferential access to the North, and the North gains from immigration controls. The likelihood that the South gains from free migration increases with the degree of internalization of the externalities.
Electrodialytic Phenomena and Their Applications in the Dairy Industry: A Review

Abstract Electrodialysis (ED) is an electrochemical separation process by which electrically-charged species are transported from one solution to another. ED is a combined method of dialysis and electrolysis and can be performed with two main cell types: multi-membrane cells for dilution-concentration and water dissociation applications (membrane phenomena), and electrolysis cells for redox reactions (electrode phenomena). The dilution-concentration principle applications in the dairy industry consist mainly of the demineralization of milk or milk by-products. The use of ED with monopolar membrane for protein separation and acid caseinate production, and in bioreactors for organic acid production, is also studied in the dairy industry. The interest of ED as a membrane process has been triggered recently by the development of a new membrane type, bipolar membrane. This membrane carries out the dissociation of water molecules. ED with bipolar membranes was applied very recently to the production of lactic acid from whey product fermentation, production of caseinates, and fractionation of whey proteins. Two principle applications of electrode reactions were published: electrochemical coagulation (EC) to precipitate milk proteins, and electroreduction for the reduction of disulfide bonds in the proteins. It appears in this article that processes using membrane phenomena are more numerous and developed than electrolytic applications. This is the composition of milk and the lack of knowledge of redox reactions of the different food compounds that limit the applications and the development of electrolytic phenomena. Electrodialytic phenomena present a great potential for application in the dairy industry, and more generally, in the food industry; many of these applications have to be discovered.
Refinement types for precisely named cache locations

Many programming language techniques for incremental computation employ programmer-specified names for cached information. At runtime, each name identifies a "cache location" for a dynamic data value or a sub-computation; in sum, these cache location choices guide change propagation and incremental (re)execution. We call a cache location name precise when it identifies at most one value or subcomputation; we call all other names imprecise, or ambiguous. At a minimum, cache location names must be precise to ensure that change propagation works correctly; yet, reasoning statically about names in incremental programs remains an open problem. As a first step, this paper defines and solves the precise name problem, where we verify that incremental programs with explicit names use them precisely. To do so, we give a refinement type and effect system, and prove it sound (every well-typed program uses names precisely). We also demonstrate that this type system is expressive by verifying example programs that compute over efficient representations of incremental sequences and sets. Beyond verifying these programs, our type system also describes their dynamic naming strategies, e.g., for library documentation purposes.
Lithium Ions Enhance Cysteine String Protein Gene Expression In Vivo and In Vitro

Abstract: Lithium is a well established pharmacotherapy for the treatment of recurrent manic‐depressive illness. However, the mechanism by which lithium exerts its therapeutic action remains elusive. Here we report that lithium at 1 mM significantly increased the expression of cysteine string proteins (CSPs) in a pheochromocytoma cell line (PC12 cells) differentiated by nerve growth factor. These cells concomitantly exhibited increased expression of CSPs in their cell bodies and boutons. Enhanced CSP expression was also observed in the brain of rats fed a lithium‐containing diet, which elevated serum lithium to a therapeutically relevant concentration of ∼1.0 mM. However, both in vitro and in vivo, the expression of another synaptic vesicle protein, synaptophysin, and the t‐SNARE, synaptosomal‐associated protein of 25 kDa (SNAP‐25), was not significantly altered by lithium. These observations indicate that lithium‐induced changes of CSP gene expression may contribute to the therapeutic efficacy of this monovalent cation.