Miracle-dz/UniFAR-FTUs huggingface dataset:
Accuracy of magnetic resonance imaging compared with computed tomography for implant planning.

AIM The objective of this study was to evaluate the reliability of magnetic resonance imaging (MRI) compared with computed tomography (CT) for dental implant planning in respect to bone measurements. METHODS Five dry mandibles were submitted to MRI and CT examinations. Each mandible had three specific sites identified with markers, in a total of 15 sites to be studied. The images provided by the MRI and CT examinations were delivered to four specialists in Oral and Maxillofacial Radiology to measure the bone height at the specific sites. Subsequently, the bone height of the dry mandibles was directly measured in the determined sites. The measurements obtained by the specialists in MRI and CT images were compared with the measurements obtained directly from the dry mandibles using the ANOVA test with a 0.05 significance level. RESULTS The differences between the measurements obtained directly from the dry mandibles and the measurements from the MRI exams varied from 0.13 to 1.67 mm, with 10 sites being overestimated in MRI exams and five sites being underestimated. The differences between the measurements from the dry mandibles and CT exams varied from 0.02 to 1.25 mm, with nine sites being overestimated in CT exams and six sites being underestimated. The differences between the measurements from the MRI and CT exams varied from 0.03 to 1.00 mm, with nine sites giving higher values in MRI exams and six sites giving higher values in CT exams. There were no statistically significant differences between the three grous of measurements (P=0.98). CONCLUSION The MRI, when compared with CT, shown to be reliable in respect to bone measurements for dental implant planning.
Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis

Cancer is a disease subject to both genetic and environmental influences. In this study, we used the RIP1-Tag2 (RT2) mouse model of islet cell carcinogenesis to identify a genetic locus that influences tumor progression to an invasive growth state. RT2 mice inbred into the C57BL/6 (B6) background develop both noninvasive pancreatic neuroendocrine tumors (PNET) and invasive carcinomas with varying degrees of aggressiveness. In contrast, RT2 mice inbred into the C3HeB/Fe (C3H) background are comparatively resistant to the development of invasive tumors, as are RT2 C3HB6(F1) hybrid mice. Using linkage analysis, we identified a 13-Mb locus on mouse chromosome 17 with significant linkage to the development of highly invasive PNETs. A gene residing in this locus, the anaplastic lymphoma kinase (Alk), was expressed at significantly lower levels in PNETs from invasion-resistant C3H mice compared with invasion-susceptible B6 mice, and pharmacological inhibition of Alk led to reduced tumor invasiveness in RT2 B6 mice. Collectively, our results demonstrate that tumor invasion is subject to polymorphic genetic control and identify Alk as a genetic modifier of invasive tumor growth.
Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia

The proto-oncogene Fli-1 is a member of the ets family of transcription factor genes. Its activation by either chromosomal translocation or proviral insertion leads to Ewing's sarcoma in humans or erythroleukemia in mice, respectively, Fli-1 is preferentially expressed in hematopoietic and endothelial cells. This expression pattern resembled that of c-ets-1, another ets gene closely related and physically linked to Fli-1. We also generated a germ line mutation in Fli-1 by homologous recombination in embryonic stem cells. Homozygous mutant mice exhibit thymic hypocellularity which is not related to a defect in a specific subpopulation of thymocytes or to increased apoptosis, suggesting that Fli-1 is an important regulator of a prethymic T-cell progenitor. This phenotype was corrected by crossing the Fli-1 deficient mice expressing Fli-1 cDNA. Homozygous mutant mice remained susceptible to erythroleukemia induction by Friend murine leukemia virus, although the latency period was significantly increased. Surprisingly, the mutant Fli-1 allele was still a target for Friend murine leukemia virus integration, and leukemic spleens with a rearranged Fli-1 gene expressed a truncated Fli-1 protein that appears to arise from an internal translation initiation site and alternative splicing around the neo cassette used in the gene targeting. The fortuitous discovery of the mutant Fli-1 protein, revealed only as the result of the clonal expansion of leukemic cells harboring a rearranged Fli-1 gene, suggests caution in the interpretation of gene-targeting experiments that result in either no or only a subtle phenotypic alteration.
Construction and pilot assessment of the Upper Limb Assessment in Daily Living Scale

Objective The upper limb function of hemiplegic patients is currently evaluated using scales that assess physical capacity or daily activities under test conditions. The present scale, the Upper Limb Assessment in Daily Living (ULADL) Scale, was developed to explore the subjective and objective functional capacities of such patients in a proximal to distal sequence. Methods A group of experts constructed a scale addressing 17 upper limb functions (five active passive and 12 active) which could be explored by a questionnaire (Q) and a test (T). Reproducibility, internal consistency, concurrent validity (Rivermead Motor Assessment (RMA)) and learning effect were estimated in a multicentre study. Results 49 stroke patients were each rated three times within 7 days by a total of 21 physicians, yielding a total of 142 ratings. The ULADL took 16±8 min to complete compared with 9±5 min for the RMA. Cronbach's alpha coefficient was 0.95 for Q and 0.97 for the practical tests (T). The global Q and T scores, and in particular the global Q score, were slightly higher at the second rating. The intra-rater intraclass correlation coefficient (ICC) was 0.65 (95% CI (0.44 to 0.79)) for Q and 0.97 (0.95 to 0.98) for T, and the inter-rater ICC was 0.95 for both Q and T. The Bland and Altman method showed good intra- and inter-rater reliability with no systematic trend. Correlation coefficients for ULADL versus RMA were >0.80 for both Q and T. Conclusions The ULADL Scale has good psychometric properties and can explore patients with different degrees of upper limb impairment.
Modeling and predicting output power losses of solar arrays in a particle filtering framework

Solar arrays are the main source of energy to on-orbit satellite. Their output power determines the use value in a great extent. Therefore, it is of great important reference value in the areas of satellite design and on-orbit satellite control to study the attenuation model of output power, to dynamically update the model based on the real-time data of output power, and to forecast the output power. This paper summarizes the influencing factors of attenuation about solar arrays output power, elaborates on the factors' trend with time and their effect on output power, and further describes the empirical model about output power varying with time. Next, it puts forward an algorithm of particle filter dynamic prediction based on the empirical model and historical data. By using the algorithm, model parameter updating and output power real-time prediction can be carried out. Finally, using six years data of solar arrays' voltage and current from a synchronous satellite in orbit, the validity of empirical model about solar arrays output power varying with time was verified based on curve fitting. Besides, the reliability and accuracy of the dynamic prediction method based on particle filter in model parameters updating and output power real-time prediction were also proved out.
Functional Forms for Tractable Economic Models and the Cost Structure of International Trade

For tractability, researchers often use equilibrium models that can be solved in closed-form. In practice, this means imposing unintended substantive restrictions on incidence properties that are central to many policy questions. To overcome this limitation, we characterize a set of joint supply and demand systems yielding closed-form solutions. This class is broad enough to allow substantial flexibility and thus realism, and it nests virtually all other tractable systems in the literature. We apply these more realistic structures to bargaining and trade models typically solved in closed-form, thereby deriving several applied insights about the cyclicality of labor hoarding, the organization of supply chains and the welfare gains from international trade. Beyond parametric examples, the Laplace Transform, a standard tool used in applied mathematics and physics in analogous settings that we exploit, provides a general approach to characterizing and approximating incidence at any degree of desired tractability. The online appendix for this paper are available at the following URL: http://ssrn.com/abstract=2575471
The Empirical Analysis of the Multiplier Influence of Electronic Money on Currency in China

The emergence of Electronic Money is the inevitable choice of financial innovation. It not only brings convenience of payment, but also brings impact to the monetary multiplier. The paper carries out the regression analysis through Granger causality test, Johansen cointegration test and error correction model for revealing the effects of Electronic Money on monetary multiplier, taking the growth rate “GEM” and the cash leakage rate “c” of the Electronic Money as the independent variables and taking narrow monetary multiplier “m1” and generalized monetary multiplier“m2” as the dependent variables.
Purification and Characterization of a Nylon-Degrading Enzyme

ABSTRACT A nylon-degrading enzyme found in the extracellular medium of a ligninolytic culture of the white rot fungus strain IZU-154 was purified by ion-exchange chromatography, gel filtration chromatography, and hydrophobic chromatography. The characteristics of the purified protein (i.e., molecular weight, absorption spectrum, and requirements for 2,6-dimethoxyphenol oxidation) were identical to those of manganese peroxidase, which was previously characterized as a key enzyme in the ligninolytic systems of many white rot fungi, and this result led us to conclude that nylon degradation is catalyzed by manganese peroxidase. However, the reaction mechanism for nylon degradation differed significantly from the reaction mechanism reported for manganese peroxidase. The nylon-degrading activity did not depend on exogenous H2O2 but nevertheless was inhibited by catalase, and superoxide dismutase inhibited the nylon-degrading activity strongly. These features are identical to those of the peroxidase-oxidase reaction catalyzed by horseradish peroxidase. In addition, α-hydroxy acids which are known to accelerate the manganese peroxidase reaction inhibited the nylon-degrading activity strongly. Degradation of nylon-6 fiber was also investigated. Drastic and regular erosion in the nylon surface was observed, suggesting that nylon is degraded to soluble oligomers and that nylon is degraded selectively.
Evaluation of Egyptian sheep production systems: II. Breeding objectives for purebred and composite breeds.

Objectives for this study were to estimate relative economic weights for performance traits for two native and two composite sheep breeds under two management systems in Egypt. Breeds studied were Rahmani (R), Ossimi (O), 3/4R-1/4Finnish Landrace (RFR), and 3/4O-1/4Finn (OFO); OFO and RFR were composite breeds. Management systems were one mating season per year (1M) and three mating seasons per 2 yr (3M). A dynamic computer model was used to simulate animal performance and enterprise efficiency and profit. Input parameters for the model were obtained from published results and analyses of data collected from experimental flocks of the same genetic stocks in Egypt. Responses for two measures of life-cycle feed conversion and one measure of enterprise profit were evaluated. Life-cycle feed conversion was calculated as kilograms of TDN input per kilogram of empty body weight output (TDN/EBW) and kilograms of TDN input per kilogram of carcass lean output (TDN/CLN). Profit was measured as annual gross margin/ewe (GM/EWE). Traits evaluated were conception rate (CR), lambing rate (LR), mortality rate (MR), mature weight (MW), and milk production (MK). Based on responses to percentage changes in trait means, CR was most important for TDN/EBW, followed by LR and MR. For TDN/CLN, LR, MR, and CR were most important. For GM/EWE, CR was most important, followed by LR, MW, and MR. In the systems studied, there was little response to changes in MK. Based on changes in GM/EWE per genetic standard deviation change, LR was most important, followed by CR, MR, MW, and MK in all systems. Relative economic weights for O and OFO were similar, as were weights for R and RFR. Differences in economic weights between management systems for the same breed were not large enough to justify separate selection lines within breeds.
Ogt-Dependent X-Chromosome-Linked Protein Glycosylation Is a Requisite Modification in Somatic Cell Function and Embryo Viability

ABSTRACT The Ogt gene encodes a glycosyltransferase that links N-acetylglucosamine to serine and threonine residues (O-GlcNAc) on nuclear and cytosolic proteins. Efforts to study a mammalian model of Ogt deficiency have been hindered by the requirement for this X-linked gene in embryonic stem cell viability, necessitating the use of conditional mutagenesis in vivo. We have extended these observations by segregating Ogt mutation to distinct somatic cell types, including neurons, thymocytes, and fibroblasts, the latter by an approach developed for inducible Ogt mutagenesis. We show that Ogt mutation results in the loss of O-GlcNAc and causes T-cell apoptosis, neuronal tau hyperphosphorylation, and fibroblast growth arrest with altered expression of c-Fos, c-Jun, c-Myc, Sp1, and p27. We further segregated the mutant Ogt allele to parental gametes by oocyte- and spermatid-specific Cre-loxP mutagenesis. By this we established an in vivo genetic approach that supports the ontogeny of female heterozygotes bearing mutant X-linked genes required during embryogenesis. Successful production and characterization of such female heterozygotes further indicates that mammalian cells commonly require a functional Ogt allele. We find that O-GlcNAc modulates protein phosphorylation and expression among essential and conserved cell signaling pathways.
Estrogen Influences Cocaine-Induced Blood Oxygen Level-Dependent Signal Changes in Female Rats

We investigated the effect of estrogen on cocaine-induced brain activity using blood oxygen level-dependent (BOLD) magnetic resonance imaging. Ovariectomized (Ovx) rats without estrogen and Ovx rats with estrogen (Ovx+E) were given a single saline or cocaine injection (15 mg/kg, i.p.) for 5 d. After 7 d of withdrawal from injections, rats were challenged with cocaine during functional imaging. Acute cocaine administration produced positive BOLD activation in the prefrontal cortex, nucleus accumbens, striatum, ventral tegmental area, and hippocampus, among other brain regions. Positive BOLD signal changes were lower in Ovx+E than in Ovx rats. With repeated cocaine administration, Ovx+E rats showed enhanced BOLD signal changes in the nucleus accumbens, ventral tegmental area, and hippocampus compared with acutely treated animals. Our results indicate that estrogen influences the effects of acute and repeated cocaine administration on BOLD signal changes. The data suggest that in females with estrogen, cocaine-induced neuronal activity is enhanced after repeated cocaine administration. It is possible that the actions of estrogen within the aforementioned brain regions potentiate the behavioral response to cocaine observed in female rats.
English teachers’ understanding of the new English language teaching program and their classroom implementations

Recent changes in Turkish educational system have increased the importance of teaching English, following a global trend to introduce foreign languages at earlier stages of the language teaching program. However, putting the new language program successfully into practice can be challenging. In this regard, this study attempts to investigate teachers’ understanding and their instructional practices on curriculum innovation in teaching English to young learners. For this aim, basic components of the new English Language Teaching Program (ELTP) (MNE, 2013) are taken as the criteria to shed light on teachers’ beliefs with reference to 4+4+4 education reform introduced in 2013 and the implementations of this reformist program in young learners’ foreign language classrooms. In this way, 232 EFL teachers who taught 2 nd , 3 rd , 4 th , 5 th , 6 th grades in Turkish state schools participated in the study. The data were collected through a questionnaire composed of three parts in an attempt to find teachers’ opinions about the starting grade for language instruction, their understanding about the new language teaching program and the implementations of this program while teaching YLs. Results indicate that teachers share almost the same opinion that foreign language instruction should start at the first grade of the education system. Despite the fact that they have mostly developed theoretically appropriate beliefs about TEYL, teachers, regarding their understanding about the new ELTP, cannot transfer their beliefs into their practices, especially with reading and writing skills in question.
Effects of Exercise Modality During Additional “High-Intensity Interval Training” on Aerobic Fitness and Strength in Powerlifting and Strongman Athletes

Abstract Androulakis-Korakakis, P, Langdown, L, Lewis, A, Fisher, JP, Gentil, P, Paoli, A, and Steele, J. Effects of exercise modality during additional “high-intensity interval training” on aerobic fitness and strength in powerlifting and strongman athletes. J Strength Cond Res 32(2): 450–457, 2018—Powerlifters and strongman athletes have a necessity for optimal levels of muscular strength while maintaining sufficient aerobic capacity to perform and recover between events. High-intensity interval training (HIIT) has been popularized for its efficacy in improving both aerobic fitness and strength but never assessed within the aforementioned population group. This study looked to compare the effect of exercise modality, e.g., a traditional aerobic mode (AM) and strength mode (SM), during HIIT on aerobic fitness and strength. Sixteen well resistance-trained male participants, currently competing in powerlifting and strongman events, completed 8 weeks of approximately effort- and volume-matched HIIT in 2 groups: AM (cycling, n = 8) and SM (resistance training, n = 8). Aerobic fitness was measured as predicted V[Combining Dot Above]O2max using the YMCA 3 minutes step test and strength as predicted 1 repetition maximum from a 4–6RM test using a leg extension. Both groups showed significant improvements in both strength and aerobic fitness. There was a significant between-group difference for aerobic fitness improvements favoring the AM group (p ⩽ 0.05). There was no between-group difference for change in strength. Magnitude of change using within-group effect size for aerobic fitness and strength was considered large for each group (aerobic fitness, AM = 2.6, SM = 2.0; strength, AM = 1.9, SM = 1.9). In conclusion, our results support enhanced strength and aerobic fitness irrespective of exercise modality (e.g., traditional aerobic and resistance training). However, powerlifters and strongman athletes wishing to enhance their aerobic fitness should consider HIIT using an aerobic HIIT mode.
Stochastic State Dependent Population Games in Wireless Communication

Much research has been devoted to the tradeoff between throughput and power consumption. Yet little has been done concerning another central challenge: the limitation on battery life. In this paper we study power control in a way that combines all above-mentioned aspects. We propose an appropriate performance metric and establish an optimization framework to analyze it: an adaptation of the Anonymous Sequential Game framework introduced in 1988 by Jovanovic and Rosenthal. We characterize the structure of the equilibrium policies, and provide a fast algorithm to reach equilibrium.
Characterization of the Treponema denticola prtP gene encoding a prolyl-phenylalanine-specific protease (dentilisin)

A chymotrypsin-like protease from Treponema denticola ATCC 35405 was purified by chromatographic techniques. The purified enzyme consisted of three polypeptides (38, 43, and 72 kDa). The protease exhibited specificity for peptide bonds containing phenylalanine and proline at the P1 and P2 positions, respectively, and was classified as a serine protease on the basis of inhibition studies. Naturally occurring protease inhibitors such as alpha1-antitrypsin and alpha1-antichymotrypsin had no effect on enzymatic activity. The enzyme degraded fibronectin, alpha1-antitrypsin, and gelatin while weakly degrading the immunoglobulin G heavy chain and type IV collagen. N-terminal amino acid sequences were determined for the 43- and 72-kDa proteins. On the basis of these sequences, the genes coding for the 43- and 72-kDa proteins were isolated and sequenced. The open reading frame which codes for the 72-kDa protein was designated prtP. This gene consists of 2,169 bp and codes for a protein with an Mr of 77,471. The protein appeared to be composed of a signal peptide region followed by a prosequence and the mature protein domain. The deduced amino acid sequence exhibited similarity with that of the Bacillus subtilis serine protease subtilisin. The deduced properties of the sequence suggest that the 72-kDa protein is a chymotrypsin-like protease. However, the nature and function of the 43-kDa protein have not yet been determined.
The Influence of Weather Conditions on Outdoor Physical Activity Among Older People With and Without Osteoarthritis in 6 European Countries.

BACKGROUND Older adults with osteoarthritis (OA) often report that their disease symptoms are exacerbated by weather conditions. This study examines the association between outdoor physical activity (PA) and weather conditions in older adults from 6 European countries and assesses whether outdoor PA and weather conditions are more strongly associated in older persons with OA than in those without the condition. METHODS The American College of Rheumatology classification criteria were used to diagnose OA. Outdoor PA was assessed using the LASA Physical Activity Questionnaire. Data on weather parameters were obtained from weather stations. RESULTS Of the 2439 participants (65-85 years), 29.6% had OA in knee, hand and/or hip. Participants with OA spent fewer minutes in PA than participants without OA (Median = 42.9, IQR = 20.0 to 83.1 versus Median = 51.4, IQR = 23.6 to 98.6; P < .01). In the full sample, temperature (B = 1.52; P < .001) and relative humidity (B = -0.77; P < .001) were associated with PA. Temperature was more strongly associated with PA in participants without OA (B = 1.98; P < .001) than in those with the condition (B = 0.48; P = .47). CONCLUSIONS Weather conditions are associated with outdoor PA in older adults in the general population. Outdoor PA and weather conditions were more strongly associated in older adults without OA than in their counterparts with OA.