Miracle-dz/UniFAR-FTUs huggingface dataset:
Is Self-mastery Always A Helpful Resource? Coping With Paradoxical Findings In Relation To Optimism And Abstinence Self-efficacy

This study investigated the relationship between three personal resources (self-mastery, optimism, and abstinence self-efficacy) and ways of coping among recovering substance abusers (n=52) residing in Oxford Houses. Although residents' scores on optimism and abstinence self-efficacy were significantly correlated in a positive direction, residents' self-mastery scores were significantly and negatively related to both optimism and abstinence self-efficacy scores. However, residents reported using significantly more emotion-focused than problem-focused coping even though there was a significant positive relationship between emotion-focused coping and self-mastery. These paradoxical findings might be due to communal living and 12-step philosophy that is antithetical to a sense of control, which may have facilitated residents' emotional regulation to stress. Furthermore, significant relationships between coping strategies and personal resources imply that active coping strategies are instrumental in recovering substance abusers' use of optimism and abstinence self-efficacy, whereas passive coping strategies are involved with self-mastery. In addition, African American residents reported using significantly more wishful thinking coping, suggesting ethnicity might be an important aspect of the coping process. Overall, findings suggest that optimism and abstinence self-efficacy are effective personal resources for recovering substance abusers in 12-step programs.
Modeling of current density distributions in critical state by commercial FE codes

The method of minimum magnetic energy variation has proved its merit in modeling the magnetic field interaction with hard type-II superconductors. Its main advantage is that the front of flux penetration is calculated starting from a physical principle equivalent to the Bean's critical state model. We have developed a procedure that adapts the above-mentioned method to the environment of the commercial finite element code ANSYS. As a step forward with respect to existing works, this allows to include magnetic materials into simulations. The case of a superconducting strip covered by a ferromagnetic sheath is reported.
Manpower substitution and productivity in medical practice: review of research.

Abstract Probably in response to the often alleged physician shortage in this country, concerted research efforts are under way to identify technically feasible opportunities for manpower substitution in the production of ambulatory health care. The approaches range from descriptive studies of the effect of task delegation on output of medical services to rigorous mathematical modeling of health care production by means of linear or continuous production functions. In this article the distinct methodological approaches underlying mathematical models are presented in synopsis, and their inherent strengths and weaknesses are contrasted. The discussion includes suggestions for future research directions.
Ribosomal Protein S6 Phosphorylation Is Involved in Novelty-Induced Locomotion, Synaptic Plasticity and mRNA Translation

The phosphorylation of the ribosomal protein S6 (rpS6) is widely used to track neuronal activity. Although it is generally assumed that rpS6 phosphorylation has a stimulatory effect on global protein synthesis in neurons, its exact biological function remains unknown. By using a phospho-deficient rpS6 knockin mouse model, we directly tested the role of phospho-rpS6 in mRNA translation, plasticity and behavior. The analysis of multiple brain areas shows for the first time that, in neurons, phospho-rpS6 is dispensable for overall protein synthesis. Instead, we found that phospho-rpS6 controls the translation of a subset of mRNAs in a specific brain region, the nucleus accumbens (Acb), but not in the dorsal striatum. We further show that rpS6 phospho-mutant mice display altered long-term potentiation (LTP) in the Acb and enhanced novelty-induced locomotion. Collectively, our findings suggest a previously unappreciated role of phospho-rpS6 in the physiology of the Acb, through the translation of a selective subclass of mRNAs, rather than the regulation of general protein synthesis.
A bidirectional and isolated three-phase rectifier with soft-switching operation

A bidirectional-power-flow three-phase rectifier with high-frequency isolation and all-digital control, based on the matrix converter topology, is analyzed in this paper. The selected topology consists of a bidirectional three-phase-to-single-phase reduced matrix converter with power-factor correction and a bidirectional active rectifier. The inclusion of the isolation transformer at the switching frequency permits the reduction of volume and weight. By synchronizing the commutation of both converters and adding a saturable inductor and a blocking capacitor it is possible to achieve soft commutation for most of the semiconductor elements. An all-digital control based on a digital-signal-processor and a field-programmable gate array was used to implement space-vector modulation and output current regulation. This power converter is intended to feed the low-energy correction magnet of a particle accelerator. Experimental results of a 1.5-kW 20-kHz prototype are presented to illustrate the performance of the proposed topology.
Incidence, Causes, and Survival Trends From Cardiovascular-Related Sudden Cardiac Arrest in Children and Young Adults 0 to 35 Years of Age: A 30-Year Review

Background— Sudden cardiac arrest is a leading cause of death in children and young adults. This study determined the incidence, cause, and outcomes of cardiovascular-related out-of-hospital cardiac arrest (OHCA) in individuals <35 years of age. Methods and Results— A retrospective cohort of OHCA in children and young adults from 1980 through 2009 was identified from the King County (Washington) Division of Emergency Medical Services' Cardiac Arrest Database. Incidence was calculated from population census data and causes of arrest determined by review of autopsy reports and all available medical records. A total of 361 cases (26 cases 0–2 years of age, 30 cases 3–13 years of age, 60 cases 14–24 years of age, and 245 cases 25–35 years of age) of OHCA were treated by emergency medical services responders, for an overall incidence of 2.28 per 100 000 person-years (2.1 in those 0–2 years of age, 0.61 in those 3–13 years of age, 1.44 in those 14–24 years of age, and 4.40 in those 25–35 years of age). The most common causes of OHCA were congenital abnormalities in those 0 to 2 years of age (84.0%) and 3 to 13 years of age (21%), presumed primary arrhythmia in those 14 to 24 of age (23.5%), and coronary artery disease in those 25 to 35 years of age (42.9%). The overall survival rate was 26.9% (3.8% in those 0–2 years of age, 40.0% in those 3–13 years of age, 36.7% in those 14–24 years of age, and 27.8% in those 25–35 years of age). Survival increased throughout the study period from 13.0% in 1980 to 1989 to 40.2% in 2000 to 2009 (P<0.001). Conclusions— The incidence of OHCA in children and young adults is higher than previously reported, and a more specific understanding of the causes should guide future prevention programs. Survival trends support contemporary resuscitation protocols for OHCA in the young.
Forearm–finger skin temperature gradient as an index of cutaneous perfusion during steady‐state exercise

The purpose of this study was to examine whether the forearm–finger skin temperature gradient (Tforearm–finger), an index of vasomotor tone during resting conditions, can also be used during steady‐state exercise. Twelve healthy men performed three cycling trials at an intensity of ~60% of their maximal oxygen uptake for 75 min separated by at least 48 h. During exercise, forearm skin blood flow (BFF) was measured with a laser‐Doppler flowmeter, and finger skin blood flow (PPG) was recorded from the left index fingertip using a pulse plethysmogram. Tforearm–finger of the left arm was calculated from the values derived by two thermistors placed on the radial side of the forearm and on the tip of the middle finger. During exercise, PPG and BFF increased (P<0·001), and Tforearm–finger decreased (P<0·001) from their resting values, indicating a peripheral vasodilatation. There was a significant correlation between Tforearm–finger and both PPG (r = −0·68; P<0·001) and BFF (r = −0·50; P<0·001). It is concluded that Tforearm–finger is a valid qualitative index of cutaneous vasomotor tone during steady‐state exercise.
Coupled enzymatic assay for estimation of branched-chain L-amino acid aminotransferase activity with 2-Oxo acid substrates.

A convenient continuous spectrophotometric assay for estimation of branched-chain L-amino acid aminotransferase activity was established: Branched-chain 2-oxo acid-dependent transamination of L-glutamate was coupled-via 2-oxoglutarate-to L-aspartate aminotransferase plus L-malate dehydrogenase or to L-alanine aminotransferase plus L-lactate dehydrogenase as indicator systems. The rate of transamination can be monitored specifically by measuring the decrease in NADH absorbance at 334 nm over time. The method was applied, e.g., for evaluation of some kinetic properties of the rat heart (iso)enzyme.
Finite Buffer Analysis of Multistage Interconnection Networks

Proposes an analysis technique for a class of Multistage Interconnection Networks (MIN's) that have finite buffers at their switch inputs and operate in a synchronous packet-switched mode. The authors examine the issue of clock period in design and analysis of synchronous MIN's and propose a model based on small clock periods. Then they analyze their "small cycle" design and compare the results with those obtained from the standard "big cycle" model that is currently used. The significant performance improvement of their model is shown based on various clock width, data width, and buffer length. >
Trellis-based R-D optimal quantization in H.263+

We describe a trellis-based algorithm which enables R-D optimum quantization decisions in the H.263+ video coding standard. The use of the trellis allows the quantization decisions for all coefficients in a block to be made jointly, and contrasts with more commonly used R-D optimizations which operate on one coefficient at a time. Experiments conducted using H.263+ for video coding rates of 40-50 kbps show an average improvement of 3.5% in bit rate, or equivalently 0.17 dB in PSNR, relative to implementations which follow the International Telecommunications Union (ITU) Test Model specifications in making quantization decisions.
CharIoT: an end-user programming environment for the IoT

Despite the breadth of related work, enabling end-users of varying technical ability to leverage sensor data to control their Internet of Things (IoT)-enabled installations remains a challenge. This work proposes a unified interface that provides three building blocks to support the end-user configuration of IoT environments: capturing higher-level events in the installation through virtual sensors, construction of automation rules with a visual overview of the current configuration and support for sharing configuration between end-users using a recommendation mechanism.
Dextran sodium sulfate strongly promotes colorectal carcinogenesis in ApcMin/+ mice: Inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms

The mouse model for familial adenomatous polyposis, ApcMin/+ mouse, contains a truncating mutation in the Apc gene and spontaneously develops numerous adenomas in the small intestine but few in the large bowel. Our study investigated whether dextran sodium sulfate (DSS) treatment promotes the development of colonic neoplasms in ApcMin/+ mice. ApcMin/+ and Apc+/+ mice of both sexes were exposed to 2% dextran sodium sulfate in drinking water for 7 days, followed by no further treatment for 4 weeks. Immunohistochemistry for cyclooxygenase‐2, inducible nitric oxide synthase, β‐catenin, p53, and nitrotyrosine, and mutations of β‐catenin and K‐ras and loss of wild‐type allele of the Apc gene in the colonic lesions were examined. Sequential observation of female ApcMin/+ mice that received DSS was also performed up to week 5. At week 5, numerous colonic neoplasms developed in male and female ApcMin/+ mice but did not develop in Apc+/+ mice. Adenocarcinomas developed in ApcMin/+ mice that received DSS showed loss of heterozygosity of Apc and no mutations in the β‐catenin and K‐ras genes. The treatment also significantly increased the number of small intestinal polyps. Sequential observation revealed increase in the incidences of colonic neoplasms and dysplastic crypts in female ApcMin/+ mice given DSS. DSS treatment increased inflammation scores, associated with high intensity staining of β‐catenin, cyclooxygenase‐2, inducible nitric oxide synthase and nitrotyrosine. Interestingly, strong nuclear staining of p53 was specifically observed in colonic lesions of ApcMin/+ mice treated with DSS. Our results suggest a strong promotion effect of DSS in the intestinal carcinogenesis of ApcMin/+ mice. The findings also suggest that strong oxidative/nitrosative stress caused by DSS‐induced inflammation may contribute to the colonic neoplasms development. © 2005 Wiley‐Liss, Inc.
Age and APOE‐ϵ4 genotype influence the effect of physostigmine infusion on the in‐vivo distribution volume of the muscarinic‐2‐receptor dependent tracer [18F]FP‐TZTP

The apolipoprotein E‐ϵ4 allele (APOE‐ϵ4) confers greater susceptibility to age‐related memory disorders. Abnormalities in the cholinergic system are likely contributors to these disorders with both age and APOE‐ϵ4 genotype modifying behavioral and physiological responses to drugs that alter cholinergic pathway function. Recently, we reported a greater in vivo distribution volume of the F‐18 labeled muscarinic‐2 (M2) selective agonist, 3‐(3‐(3‐[18F]Flouropropyl)thio)‐1,2,5‐thiadiazol‐4‐yl)‐1,2,5,6‐tetrahydro‐1‐methylpyridine ([18F]FP‐TZTP), in aging healthy subjects with an APOE‐ϵ4 allele. To examine the effects of aging and the APOE‐ϵ4 allele on the response of the muscarinic component of cholinergic pathway to pharmacologic augmentation, two [18F]FP‐TZTP PET scans were conducted in 19 subjects varying in age from 22 to 74 years, the first served as baseline for the second scan that was performed while the subjects were either infused with saline (n = 6) or with the acetylcholinesterase inhibitor physostigmine (6 with an APOE‐ϵ4 allele and 7 without an APOE‐ϵ4 allele). Using a multiple regression analysis, both AGE (β = 0.621 ± 0.135, B = 0.353 ± 0.077, t(10) = 4.61, P < 0.001) and APOE‐ϵ4 genotype (β = 0.742, B = 14.8 ± 2.69, t(10) = 5.51, P < 0.0003) were found to be significant contributors to subject response to physostigmine. The adjusted R2 for the model as a whole was 0.786 (F(2,10) = 23.00, P < 0.0002) with both increasing age and the presence of the APOE‐ϵ4 allele modifying the response to physostigmine in the direction of larger decreases in [18F]FP‐TZTP distribution volumes in all brain regions examined. The findings, particularly the absence of an interaction between AGE and APOE‐ϵ4 genotype, contribute to the growing body of evidence that suggests that the APOE‐ϵ4 genotype is likely to contribute to brain structure and function prior to aging. Synapse 60:86–92, 2006. Published 2006 Wiley‐Liss, Inc.
Pediatric reference intervals for plasma and urine essential amino acids in a Turkish population.

AIM To establish age- and sex-specific reference intervals for essential amino acids in a healthy Turkish pediatric population. MATERIALS AND METHODS A total of 945 clinically healthy children (531 boys and 414 girls, ranging in age from birth to 14 years) were enrolled. Plasma and urine amino acids' concentrations were measured by high-performance liquid chromatography. RESULTS Concentrations of essential amino acids in plasma were higher in girls than in boys in the age groups of 0-1 months and 7-14 years; however, there was no difference in the other age groups. Concentrations of essential amino acids in urine were higher in girls than in boys in the age group of 0-1 months; however, there was no difference in the other age groups. Our results demonstrated the sex-related differences in concentrations ofleucine, isoleucine, valine, phenylalanine, lysine, and histidine in plasma, which increased with age in boys but not in girls. The concentrations of leucine, tryptophan, methionine, and lysine in urine declined with age in girls but not in boys, which were sex-related differences, too. CONCLUSION We defined essential amino acids' reference intervals in a Turkish pediatric population.
The Use of Antidepressants, Anxiolytics, and Hypnotics in People with Type 2 Diabetes and Patterns Associated with Use: The Hoorn Diabetes Care System Cohort

Objective. With depression being present in approximately 20% of people with type 2 diabetes mellitus (T2DM), we expect equally frequent prescription of antidepressants, anxiolytics, and hypnotics. Nevertheless, prescription data in people with T2DM is missing and the effect of depression on glycaemic control is contradictory. The aim of this study was to assess the prevalence of antidepressants, anxiolytics, and/or hypnotics use in a large, managed, primary care system cohort of people with T2DM and to determine the sociodemographic characteristics, comorbidities, T2DM medication, and metabolic control associated with its use. Method. The prevalence of antidepressants, anxiolytics, and/or hypnotics use in the years 2007–2012 was assessed in the Hoorn Diabetes Care System Cohort from the Netherlands. Results. From the 7016 people with T2DM, 500 people (7.1%) used antidepressants only, 456 people (6.5%) used anxiolytics and/or hypnotics only, and 254 people (3.6%) used a combination. Conclusion. We conclude that in our managed, primary care system 17% of all people with T2DM used antidepressants, anxiolytics, and/or hypnotics. Users of antidepressants, anxiolytics, and/or hypnotics were more often female, non-Caucasian, lower educated, and more often treated with insulin.
Development and impact of hooks of high droplet concentration on remote southeast Pacific stratocumulus

Abstract. Over the southeastern Pacific (SEP), droplet concentration ( N d ) in the typically unpolluted marine stratocumulus west of 80° W (> 1000 km offshore) is periodically strongly enhanced in zonally elongated "hook"-shaped features that increase albedo. Here, we examine three hook events using the chemistry version of the Weather Research and Forecasting model (WRF-Chem) with 14 km horizontal resolution, satellite data, and aircraft data from the VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx). A particularly strong hook yields insights into the development, decay, and radiative impact of these features. Hook development occurs with N d increasing to polluted levels over the remote ocean primarily due to entrainment of cloud condensation nuclei (CCN) from the lower free troposphere (FT). The feature advects northwestward until the FT CCN source is depleted, after which N d decreases over a few days due to precipitation and dilution. The model suggests that the FT CCN source supplying the hook consists of high concentrations of small accumulation-mode aerosols that contribute a relatively small amount of aerosol mass to the MBL, in agreement with near-coast VOCALS measurements of polluted layers in the FT. The aerosol particles in this hook originate mainly from a pulse of offshore flow that transports Santiago-region (33–35° S) emissions to the remote marine FT. To provide pollution CCN that can sustain hooks, the FT transport of pollution plumes to the remote ocean requires strong, deep offshore flow. Such flow is favored by a trough approaching the South American coast and a southeastward shift of the climatological subtropical high-pressure system. The model simulations show precipitation suppression in the hook and a corresponding increase in liquid water path (LWP) compared with a simulation without anthropogenic sources. LWP also increases as the hook evolves over time due to increasing stability and decreasing subsidence. WRF-Chem suggests that dimethyl sulfide (DMS) significantly influences the aerosol number and size distributions in a hook, but that hooks do not form without FT CCN. The Twomey effect contributes ~ 50–70% of the albedo increase due to the presence of the hook, while secondary aerosol indirect effects and meteorological influences also contribute significantly. The source of hook aerosols is difficult to determine with the available observations alone. The model provides further explanation of the factors influencing hook formation. Two other weaker hooks during VOCALS-REx are not as well simulated but are also associated with FT offshore flow near Santiago. Hooks demonstrate the importance of free-tropospheric transport of aerosols in modulating the droplet concentration in the southeastern Pacific stratocumulus deck, and present a formidable challenge to simulate accurately in large-scale models.
Types for Location and Data Security in Cloud Environments

Cloud service providers are often trusted to be genuine, the damage caused by being discovered to be attacking their own customers outweighs any benefits such attacks could reap. On the other hand, it is expected that some cloud service users may be actively malicious. In such an open system, each location may run code which has been developed independently of other locations (and which may be secret). In this paper, we present a typed language which ensures that the access restrictions put on data on a particular device will be observed by all other devices running typed code. Untyped, compromised devices can still interact with typed devices without being able to violate the policies, except in the case when a policy directly places trust in untyped locations. Importantly, our type system does not need a middleware layer or all users to register with a preexisting PKI, and it allows for devices to dynamically create new identities. The confidentiality property guaranteed by the language is defined for any kind of intruder: we consider labeled bisimilarity i.e. an attacker cannot distinguish two scenarios that differ by the change of a protected value. This shows our main result that, for a device that runs well typed code and only places trust in other well typed devices, programming errors cannot cause a data leakage.
Prevalence of headache in Australian footballers

Objective: To survey the prevalence and risk factors for headache in a population of elite professional Australian footballers. Methods: A prospective questionnaire based survey was performed on elite Australian footballers participating in a national competition. The survey was designed to assess the prevalence and risk factors for headache using standardised International Headache Society (HIS) criteria. Headache prevalence was compared with that of an age and sex matched community control population. Results: A total of 160 questionnaires were analysed. Headaches were reported by 80% of subjects, with 49% of respondents reporting headaches during competitive match play and 60% during training. There was no significant difference between the footballers and the community sample in the number of headaches ever; however, they did report more headaches in the three months before the survey —that is, during the competitive playing season. In the footballers, 22% of headaches conformed to the strict IHS definition of migraine headaches. When the relaxed definition of “footballer’s migraine” was used, 34% of headaches met these criteria. Footballers were at significantly increased risk of footballer’s migraine than community controls. Conclusions: Headaches are common in Australian footballers, and the prevalence of migraine is increased in relation to community prevalence studies. Furthermore, the strict IHS criteria may not adequately identify the specific subtype of football related headache. This finding has important implications in the management of headache in this setting.