Miracle-dz/UniFAR-FTUs huggingface dataset:
Sex Offender Laws: Failed Policies, New Directions

New to the second edition: Emphasizes policy and program alternatives to currently ineffective policies Provides new content on the criminalization of adolescent sexuality Analyzes the role of the media in sex offense and sex offense policies Critically discusses state implementation of the 2006 Adam Walsh Act Introduces new policy alternatives including environmental criminology and its use toward sexual violence prevention and the increasing use of civil litigation in sexual assault cases Examines the political "untouchability" of sex offender laws and their adverse affects and unintended consequences
MRI Evaluation of Lumbar Endplate and Facet Erosion in Rheumatoid Arthritis

Study Design: A cross-sectional study. Objective: This study was aimed to quantify the extent of lumbar endplate and facet joint erosion in patients with rheumatoid arthritis (RA) using magnetic resonance imaging, to calculate the prevalence of erosion, and sought correlated factors. Summary of Background Data: Few studies have examined the lumbar spine in RA, especially the relationship between endplate and facet joint erosions and lumbar lesions induced by RA. Methods: A total of 201 patients with RA were enrolled. Lumbar endplate and facet joint erosion were defined as irregularities and low-intensity change on magnetic resonance imaging, and graded utilizing the Rheumatoid Arthritis Magnetic Resonance Imaging Score. Lumbar lesions were defined as scoliosis, spondylolisthesis, and vertebral fracture on plain x-ray. Multivariable logistic regression analysis was used to seek correlations between the erosion and spinal level, RA-related factors and x-ray findings. Results: Lumbar endplate and facet erosion were detected in 70.6% and 76.6% of individuals, respectively, and at 33.8% and 38.7% of lumbar intervertebral levels, respectively. The severity of erosion in individual patients correlated with lumbar lesions. Endplate and facet erosion at each level correlated with high disease activity, and were most common at mid-lumbar and lower-lumbar levels. Strong correlations were observed between endplate erosion and adjacent vertebral body fracture or disk degeneration, and between facet erosion and spondylolisthesis. Conclusions: Lumbar endplate and facet erosion are common in RA, and are observed more frequently at mid-low levels and when RA is poorly controlled. This pattern of erosion may play a crucial role in the generation of lumbar lesions in RA.
Psychiatric symptoms in cancer patients. Is the cause organic or psychologic?

Because cancer and its treatment have so many effects on the CNS, the diagnosis of psychiatric symptoms in cancer patients is problematic. Naturally there are psychologic and psychosocial issues that often sufficiently explain why a patient appears distressed. Dealing with psychologic adjustment is always an important part of the management of patients with severe medical, as opposed to psychiatric, illness, whether or not biologic components of the psychologic problem can be identified and addressed. The most frequent error physicians make in evaluating psychiatric symptoms is to assume that a psychologic explanation is sufficient. Expressions such as "Wouldn't you be depressed if you had cancer? " are often used to excuse failure to pursue further evaluation. Careful reviews of cases in which cancer patients were labeled as having psychologic problems have consistently shown a high incidence of misdiagnosis. Correct diagnosis and treatment of an underlying organic disorder can alleviate symptoms that impair the patient's innate coping resources, allowing him or her to grapple more effectively with adverse circumstances.
Impact of Working Capital Management on Financial Performance of Listed Manufacturing Firms in Nigeria

This paper is an empirical analysis of the impact of working capital management on financial performance of listed manufacturing firms in Nigeria for the period of seven years (2011 to 2016). The population consists of ninety onenbsp (91) listed manufacturing firms in Nigeria Stock Exchange and the paper used forty seven (47)as the sample size. The study aims to investigate whether working capital management (proxy cash conversion cycle and Inventory Turnover in Days,) have any significant contribution on firmrsquos financial performance. The study adopted Simple Regression Analysis technique and data were collected from secondary source through the audited annual reports and accounts of the firms. The findings reveal that working capital management influences firmrsquos performance. Therefore it recommended that the listed manufacturing firms should maintain a considerable number of days in managing the process of converting raw materials to finish goods and cash collection to improve firmsrsquo performance.
Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia

Background: Mutations in the JARID1C (Jumonji AT-rich interactive domain 1C) gene were recently associated with X-linked mental retardation (XLMR). Mutations in this gene are reported to be one of the relatively more common causes of XLMR with a frequency of approximately 3% in males with proven or probable XLMR. The JARID1C protein functions as a histone 3 lysine 4 (H3K4) demethylase and is involved in the demethylation of H3K4me3 and H3K4me2. Methods: Mutation analysis of the JARID1C gene was conducted in the following cohorts: probands from 23 XLMR families linked to Xp11.2, 92 males with mental retardation and short stature, and 172 probands from small XLMR families with no linkage information. Results: Four novel mutations consisting of two missense mutations, p.A77T and p.V504M, and two frame shift mutations, p.E468fsX2 and p.R1481fsX9, were identified in males with mental retardation. Two of the mutations, p.V504M and p.E468fsX2, are located in the JmjC domain of the JARID1C gene where no previous mutations have been reported. Additional studies showed that the missense mutation, p.V504M, was a de novo event on the grandpaternal X chromosome of the family. Clinical findings of the nine affected males from the four different families included mental retardation (100%), short stature (55%), hyperreflexia (78%), seizures (33%) and aggressive behaviour (44%). The degree of mental retardation consisted of mild (25%), moderate (12%) and severe (63%). Conclusion: Based on the clinical observations, male patients with mental retardation, short stature and hyperreflexia should be considered candidates for mutations in the JARID1C gene.
Perturbative Quantum Gravity from Gauge Theory

In this talk we give an overview of some recent developments in gauge and gravity theories, focusing on a new duality between color and kinematics. This duality allows us to construct gravity amplitudes by a simple replacement of color factors by kinematic numerator factors. Applications of these ideas for determining the ultraviolet compatibility of supersymmetric versions of Einstein gravity with quantum mechanics are explained.
CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American

Dysregulation in the circadian system induced by variants of clock genes has been associated with type 2 diabetes. Evidence for the role of cryptochromes, core components of the system, in regulating glucose homeostasis is not supported by CRY1 candidate gene association studies for diabetes and insulin resistance in human, suggesting possible dietary influences. The purpose of this study was to test for interactions between a CRY1 polymorphism, rs2287161, and carbohydrate intake on insulin resistance in two independent populations: a Mediterranean (n = 728) and an European origin North American population (n = 820). Linear regression interaction models were performed in two populations to test for gene–diet interactions on fasting insulin and glucose and two insulin-related traits, homeostasis model assessment of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). In addition, fixed effects meta-analyses for these interactions were performed. Cohort-specific interaction analyses showed significant interactions between the CRY1 variant and dietary carbohydrates for insulin resistance in both populations (p < 0.05). Findings from the meta-analyses of carbohydrate–single nucleotide polymorphism interactions indicated that an increase in carbohydrate intake (% of energy intake) was associated with a significant increase in HOMA-IR (p = 0.011), fasting insulin (p = 0.007) and a decrease in QUICKI (p = 0.028), only among individuals homozygous for the minor C allele. This novel finding supports the link between the circadian system and glucose metabolism and suggests the importance this CRY1 locus in developing personalized nutrition programs aimed at reducing insulin resistance and diabetes risk.
THE INFLUENCE OF DEMOGRAPHIC FACTORS ON SOUTH AFRICAN INVESTORS' LIFE SATISFACTION

Satisfaction with life is not always a set concept and may vary according to the demography of investors. Demographical factors can classify investors into various categories of life satisfaction, which can ultimately impact investment decisions. The level of life satisfaction can influence investment by causing a deviation between expected and actual investment choices. Gender can be grouped between males and females with different investment decisions based on each group? s satisfaction with life. The aim of this study is to determine the satisfaction with life of investors considering their gender, age group, ethnicity, income group and marital status. The results of the study show that male investors are more likely to have a positive life satisfaction and make optimistic investment choices compared to female investors. Investors who are older than 50 years of age, married or earn more than R700 000 annually are more likely to have a positive life satisfaction and make more optimistic investment choices, while investors with a negative life satisfaction are more likely to make pessimistic investment choices.
Acute conduction velocity changes in guinea-pigs after administration of diphenylhydantoin

Motor nerve conduction velocity was measured after dosing guinea-pigs with 200-400 μmol/kg diphenylhydantoin (DPH) daily for three to four days. Conduction velocity fell by a mean value of 13% in animals that achieved plasma DPH levels over 200 μmol/l. There was no change in velocity with DPH levels below this value.
Incremental risks in Web 2.0 applications

Purpose – The purpose of this paper is to identify and investigate the security issues an organisation operating in the “new” online environment is exposed to through Web 2.0 applications, with specific focus on unauthorised access (encompassing hackers). The study aims to recommend possible safeguards to mitigate these incremental risks to an acceptable level.Design/methodology/approach – An extensive literature review was performed to obtain an understanding of the technologies driving Web 2.0 applications. Thereafter, the technologies were mapped against Control Objectives for Information and Related Technology (CobiT) and Trust Service Principles and Criteria and associated control objectives relating to security risks, specifically to hacker risks. These objectives were used to identify relevant risks and formulate appropriate internal control measures.Findings – The findings show that every organisation, technology and application is unique and the safeguards depend on the nature of the organisation.
A sectional matrix method for IPT coil shape optimization

In this paper, Neumann's integral is evaluated for computing self-inductance using a multi-turn sectional matrix method. Analytical equations are derived considering the increase in dimensions of the coil due to an impinging air-gap between the turns. The resulting sectional self-inductance matrix is computed and the concepts of sectional partial self-inductance and sectional partial mutual inductance are introduced. The effects of the various partial inductances are considered as a function of the air-gap, dimensions and turns. Further, the mutual inductance of a pair of coils is considered and the coupling is obtained analytically. The coils considered are to be used for shape optimization of IPT coils. Finally, the results are compared with experimentation. This technique being generic can be applied to a number of different polygonal shapes and can be further simplified by the theory of vector decomposition of current elements. A case study with self-inductance and perimeter as optimization objective is considered.
Consideration to minimize power losses in synchronous rectification

A synchronous rectification in high performance converter design is an essential block for low voltage and high current applications since significant efficiency and power density improvements can be achieved by replacing schottky rectification with synchronous rectification MOSFETs. Many critical parameters for synchronous rectification MOSFETs and even parasitic components in devices and printed circuit board directly affect to system efficiency of synchronous rectifications. Optimization of the MOSFETs plays an important role in improving efficiency of synchronous rectification. This paper shows the impact of power MOSFET parameters and parasitic inductance on efficiency of synchronous rectification through loss analysis of power MOSFET from an experiment and a simulation results.
The effect of nitrate, iodide and bromide on the duration of the active state in skeletal muscle

If a frog’s skeletal muscle is soaked in modified Ringer’s fluid, containing bromide, nitrate or iodide in place of chloride, the tension and duration of a twitch, and its heat production, are largely increased, in the order Br<NO3<I. In a tetanic contraction, however, the tension, the heat production and the velocity of shortening under any load are unaffected. The primary effect of these anions, acting on the excitable surface of the muscle fibres, is to increase the duration of the active state after a shock; the increased tension and heat in a twitch result from this. The rate at which the effect comes on after sudden immersion of a muscle in iodide-Ringer depends solely on the rate at which iodide diffuses into the interspaces between the fibres; the rate of penetration of iodide into the fibres is very slow. The effect is not due to any direct action of the anion on the contractile mechanism, for (1) it passes off rapidly, when a muscle after long soaking in iodide-Ringer is transferred to chloride-Ringer, although iodide remains inside for a long time, and (2) the tetanic contraction is unaffected. If the fundamental 'unit’ of contraction were a cycle of events triggered by excitation and then running its own course to completion, the duration of the active state would be an intrinsic property of the contractile mechanism and would not depend on something outside it. But if the active contractile state is set up and maintained in the interior by some influence transmitted from the excitable surface outside, its duration would depend on the time course of the responsible process at the surface. The facts (a) that the duration is greatly affected by the presence of, for example, iodide in the interspaces between the fibres, at a time when there is practically none of it inside the fibres, and (b) that the effect rapidly passes off as iodide is removed from the interspaces although a large amount of it may still be inside, is decisive evidence for the second view. These abnormal anions somehow affect the time course of the process, started by excitation, in the surface of the fibres from which the active contractile state is transmitted into and maintained in the interior. This exposes a new link in the chain of events connecting excitation with contraction.
Analysis of the DNA-binding activity of p53 mutants using functional protein microarrays and its relationship to transcriptional activation

Abstract Sequence-specific DNA binding is the key function through which tumor suppressor p53 exerts transactivation of the downstream target genes, often being impaired in cancer cells by mutations in the TP53 gene. Functional protein microarray technology enables a high-throughput parallel analysis of protein properties within one experiment under the same conditions. Using an array approach, we analyzed the DNA binding activity of wild type p53 protein and of 49 variants. Our results show significant differences in the binding properties between the p53 mutants. The C-terminal mutant R337C displayed the highest DNA binding activity on the array. However, the same mutant showed only a partial activation in the reporter gene assay and almost no activation of downstream target genes after transfection of expression vector into cells lacking endogenous p53. These observations demonstrate that DNA binding itself is not sufficient for activating the p53 target genes in at least some of the p53 mutants and, therefore, in vitro studies might not always reflect in vivo conditions.
Chaperonin of Group I: Oligomeric Spectrum and Biochemical and Biological Implications

Chaperonins play various physiological roles and can also be pathogenic. Elucidation of their structure, e.g., oligomeric status and post-translational modifications (PTM), is necessary to understand their functions and mechanisms of action in health and disease. Group I chaperonins form tetradecamers with two stacked heptameric rings. The tetradecamer is considered the typical functional complex for folding of client polypeptides. However, other forms such as the monomer and oligomers with smaller number of subunits than the classical tetradecamer, also occur in cells. The properties and functions of the monomer and oligomers, and their roles in chaperonin-associated diseases are still incompletely understood. Chaperonin I in eukaryotes occurs in various locations, not just the mitochondrion, which is its canonical place of residence and function. Eukaryotic Chaperonin I, namely Hsp60 (designated HSP60 or HSPD1 in humans) has, indeed, been found in the cytosol; the plasma-cell membrane; on the outer surface of cells; in the intercellular space; in biological liquids such as lymph, blood, and cerebrospinal fluid; and in secretions, for instance saliva and urine. Hsp60 has also been found in cell-derived vesicles such as exosomes. The functions of Hsp60 in all these non-canonical locales are still poorly characterized and one of the questions not yet answered is in what form, i.e., monomer or oligomer, is the chaperonin present in these non-canonical locations. In view of the steady increase in interest on chaperonopathies over the last several years, we have studied human HSP60 to determine its role in various diseases, its locations in cells and tissues and migrations in the body, and its post-translational modifications that might have an impact on its location and function. We also carried out experiments to characterize the oligomeric status of extramitochondrial of HSP60 in solution. Here, we provide an overview of our results, focusing on the oligomeric equilibrium and stability of the various forms of HSP60 in comparison with GroEL. We also discuss post-translational modifications associated with anti-cancer drugs to indicate the potential of Hsp60 in Medicine, as a biomarker and etiopathogenic factor.
Bidirectional Virus Secretion and Nonciliated Cell Tropism following Andes Virus Infection of Primary Airway Epithelial Cell Cultures

ABSTRACT Hantavirus pulmonary syndrome (HPS) is an acute disease resulting from infection with any one of a number of New World hantaviruses. HPS has a mortality rate of 40% and, unlike many other severe respiratory diseases, often occurs in young, healthy adults. Infection is usually initiated after inhalation of rodent excreta containing virus particles, but human-to-human transmission has been documented. Postmortem tissue samples show high levels of viral antigen within the respiratory endothelium, but it is not clear how the virus can traverse the respiratory epithelium in order to initiate infection in the microvasculature. We have utilized Andes virus infection of primary, differentiated airway epithelial cells to investigate the ability of the virus to interact with and cross the respiratory epithelium. Andes virus infects the Clara and goblet cell populations but not the ciliated cells, and this infection pattern corresponds to the expression of β3 integrin, the viral receptor. The virus can infect via the apical or basolateral membrane, and progeny virus particles are secreted bidirectionally. There is no obvious cytopathology associated with infection, and β3 integrins do not appear to be critical for respiratory epithelial cell monolayer integrity. Our data suggest that hantavirus infection of the respiratory epithelium may play an important role in the early or prodrome phase of disease as well as serving as a source of virus involved in transmission.
Internalization of Values Academic Integrity and Its Effect onPerformance of Financial Management at Universitas Tanjungpura Pontianak Indonesia

The Research Problems came from Universitas Tanjungpura, Pontianak Indonesia because in 2016 managing funds amounting to 100 billion Rupiah and managed by 9 faculties, agencies and unit. Management of these funds need to be escorted to the values of academic integrity. The purpose of the study (1) to determine the process of internalizing the values of academic integrated, (2) to determine the effect of partial and simultaneous honesty, fairness, trust, respect, and commitment on the performance of financial management staff. The method used is survey method with explanation approach. The research sample as many as 30 people. The results showed (1) the process of internalizing the values of academic integrity conducted by three processes, namely the transformation, transaction, internalization, (2) there is a partial effect and simultaneous values of academic integrity which includes honesty, fairness, trust, respect, and commitment on the performance of financial management staff.
Understanding Collaborative Technologies Adoptive and Post-Adoptive Outcomes: a Longitudinal Study

Numerous studies in the Information Systems (IS) domain explain what determines user adoption of collaborative information technology (IT) in the workplace. Few, however, explain what the influences of collaborative IT adoption on behaviors are over time. Partly based on DeLone and McLean (2003), this paper fills this knowledge gap by formulating and testing a model positing that IT adoption (system usage and satisfaction) influences perceived benefits (flow and collaborative performance) and post-adoptive behaviors (trying to innovate and creativity). In order to test the research model, a longitudinal survey has been conducted over a 6 months period of time with actual users of a collaborative platform based on the Google Apps Service in an insurance company. The results show that; as expected, IT adoption does influence perceived benefits, which in turn influence post-adoptive behaviors. This latter influence is mediated by trust in the IT. The results are discussed and contributions to theory and practice are emphasized.