Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk assessment behaviors associated with corticosterone trigger the defense reaction to social isolation in rats: Role of the anterior cingulate cortex

The extent to which the hypothalamic–pituitary–adrenal axis is activated by short-term and long-term consequences of stress is still open to investigation. This study aimed to determine (i) the correlation between plasma corticosterone and exploratory behavior exhibited by rats subjected to the elevated plus maze (EPM) following different periods of social isolation, (ii) the effects of the corticosterone synthesis blocker, metyrapone, on the behavioral consequences of isolation, and (iii) whether corticosterone produces its effects through an action on the anterior cingulate cortex, area 1 (Cg1). Rats were subjected to 30-min, 2-h, 24-h, or 7-day isolation periods before EPM exposure and plasma corticosterone assessments. Isolation for longer periods of time produced greater anxiogenic-like effects on the EPM. However, stretched attend posture (SAP) and plasma corticosterone concentrations were increased significantly after 30 min of isolation. Among all of the behavioral categories measured in the EPM, only SAP positively correlated with plasma corticosterone. Metyrapone injected prior to the 24 h isolation period reversed the anxiogenic effects of isolation. Moreover, corticosterone injected into the Cg1 produced a selective increase in SAP. These findings indicate that risk assessment behavior induced by the action of corticosterone on Cg1 neurons initiates a cascade of defensive responses during exposure to stressors.
Delta Power Is Higher and More Symmetrical in Ischemic Stroke Patients with Cortical Involvement

A brain injury resulting from unilateral stroke critically alters brain functionality and the complex balance within the cortical activity. Such modifications may critically depend on lesion location and cortical involvement. Indeed, recent findings pointed out the necessity of applying a stratification based on lesion location when investigating inter-hemispheric balance in stroke. Here, we tested whether cortical involvement could imply differences in band-specific activity and brain symmetry in post stroke patients with cortico-subcortical and subcortical strokes. We explored brain activity related to lesion location through EEG power analysis and quantitative Electroencephalography (qEEG) measures. Thirty stroke patients in the subacute phase and 10 neurologically intact age-matched right-handed subjects were enrolled. Stroke patients were equally subdivided in two groups based on lesion location: cortico-subcortical (CS, mean age ± SD: 72.21 ± 10.97 years; time since stroke ± SD: 31.14 ± 11.73 days) and subcortical (S, mean age ± SD: 68.92 ± 10.001 years; time since stroke ± SD: 26.93 ± 13.08 days) group. We assessed patients’ neurological status by means of National Institutes of Health Stroke Scale (NIHSS). High density EEG at rest was recorded and power spectral analysis in Delta (1–4 Hz) and Alpha (8–14 Hz) bands was performed. qEEG metrics as pairwise derived Brain Symmetry Index (pdBSI) and Delta/Alpha Ratio (DAR) were computed and correlated with NIHSS score. S showed a lower Delta power in the Unaffected Hemisphere (UH) compared to Affected Hemisphere (AH; z = −1.98, p < 0.05) and a higher Alpha power compared to CS (z = −2.18, p < 0.05). pdBSI was negatively correlated with NIHSS (R = −0.59, p < 0.05). CS showed a higher value and symmetrical distribution of Delta band activity (z = −2.37, p < 0.05), confirmed also by a higher DAR value compared to S (z = −2.48, p < 0.05). Patients with cortico-subcortical and subcortical lesions show different brain symmetry in the subacute phase. Interestingly, in subcortical stroke patient brain activity is related with the clinical function. qEEG measures can be explicative of brain activity related to lesion location and they could allow precise definition of diagnostic-therapeutic algorithms in stroke patients.
An 11 bit SAR ADC combining a split capacitor array with a resistive ladder and a configurable noise time domain comparator

This paper presents a successive approximation analog to digital converter with a configurable resolution of 8 or 11 bit. The resolutions are achieved by combining an 8 bit split capacitor array with a 3 bit resistive ladder allowing for a simpler layout and good power efficiency. Configurable buffers are included and enable a wide range of operation frequencies. Sample rates between 300S/s and 80kS/s were tested where at the lower frequency a total current consumption of just 8.4nA was measured. A configurable time domain comparator is employed to adapt the noise requirement to the desired resolution. The circuit is developed in a 130nm CMOS technology and occupies an active area of 0.0664mm2.
Classification de Données Cérébrales par Système d'Inférence Flou pour l'Utilisation d'Interfaces Cerveau-Ordinateur en Réalité Virtuelle

Cet article a deux objectifs principaux. Le premier est de proposer un etat-de-l'art sur l'utilisation des interfaces cerveau-ordinateur en realite virtuelle. De telles interfaces permettent a un utilisateur d'envoyer des commandes a un ordinateur en faisant varier son activite cerebrale, cette derniere etant mesuree et traitee par le systeme. Le deuxieme objectif est de pr´esenter les premiers resultats que nous avons obtenus dans le but de concevoir une interface cerveau-ordinateur. Au cours de ces travaux, nous avons demontre l'interet des syteemes d'inference flous pour la classifi- cation de differents types d'activite cerebrale. A terme, il est envisage d'utiliser ces algorithmes au sein d'une interface cerveau-ordinateur couplee a un environnement virtuel.
Knowledge management as enabling R&D innovation in high tech industry: the case of SAIT

The purpose is to present a knowledge management model for R&d organizations and discuss how to employ it for their innovation. This paper first derives generic elements for effective KM implementation through literature reviews. Then, considering the elements, this paper develops an integrative KM model for enabling R&D innovation. Next, this paper analyzes the case of Samsung Advanced Institute of Technology (SAIT), which has performed KM‐based innovation activities on the basis of the model presented in this paper. Finally, this paper discusses the lessons and implications from SAIT’s knowledge management initiatives. To achieve KM‐based innovation successfully in an R&D organization, its generic characteristics should be considered essentially in designing KM activities. From the case analysis of SAIT KM which employs this perspective, the following critical success factors are found: KM measurements metrics to stimulate a strong relationship between KM activities and the organization’s competitiveness, knowledge templates to enable the consistent management of core knowledge, various information group activities to generate meaningful new ideas, and IT systems and rules to satisfy researchers’ individual aspiration for self development. The research limitations/implications are that to generalize the usefulness of the proposed model, more cases need to be analyzed. The practical implications are that the proposed R&D KM model and analyses on the real‐life KM case of SAIT may be employed as significant benchmarking information in other R&D organizations. This paper presents an integrative KM model considering the generic features of R&D organizations.
, Manuela Branco and moth phenologically atypical population of the pine processionary Genetic isolation through time : allochronic differentiation of a

References http://rspb.royalsocietypublishing. org/content/274/1612/935.full. html#related-urls Article cited in: http://rspb.royalsocietypublishing. org/content/274/1612/935.full. html#ref-list-1 This article cites 30 articles, 8 of which can be accessed free Email alerting service here right-hand corner of the article or click Receive free email alerts when new articles cite this article sign up in the box at the top
Network of Neural Oscillators for Retrieving Phase Information.

We propose a network of oscillators to retrieve given patterns in which the oscillators keep a fixed phase relationship with one another. In this description, the phase and the amplitude of the oscillators can be regarded as the timing and the strength of the neuronal spikes, respectively. Using the amplitudes for encoding, we enable the network to realize not only oscillatory states but also non-firing states. In addition, it is shown that under suitable conditions the system has a Lyapunov function ensuring a stable retrieval process. Finally, the associative memory capability of the network is demonstrated numerically.
Phenytoin Is an Estrogen Receptor α-Selective Modulator That Interacts With Helix 12

Rationale: Phenytoin (Dilantin®; DPH) is used to treat epilepsy but causes estrogen agonist–antagonist-like side effects. We investigated the interaction of phenytoin with estrogen receptors (ERs) α and β by computational molecular docking, ER competition binding, transcriptional assays, and biological actions, comparing outcomes with estradiol (E2), estrone (E1), and tamoxifen (TMX). Experimental: (1) The DPH docking to 3-dimensional crystal structures of the ERα ligand-binding domain (LBD) showed a high degree of structural complementarity (−57.15 calculated energy units, approximating kcal/mol) with the ligand-binding pocket, including a contact at leucine (L540) in helix 12. Estrogen receptor β showed slightly less favorable interactions (−54.27 kcal/mol), without contacting L450. Estradiol, E1, and TMX contact points with ERα and ERβ do not include L450. (2) Cellular actions: Incubation of cells transfected with ERα or ERβ and a luciferase promoter phenytoin was several orders weaker than E2 as an agonist through ERα and had no effect through ERβ. However, phenytoin at clinical concentrations (10−11 to 10−6 mol/L) powerfully antagonized action of E2 on ERα-expressing cells. Similarly, phenytoin at clinically effective concentrations marginally induced alkaline phosphatase by ERα- and ERβ-expressing endometrial cancer cells but at doses well below clinical effectiveness blocked E2-induced alkaline phosphatase. (3) ER competition: In Scatchard plots comparing phenytoin with 17β-estradiol against endometrial cancer cell cytosol E2-alone more effectively displaced labeled E2 than phenytoin, but phenytoin was approximately equimolar effective to E2 in inhibiting E2’s displacement of the radiolabel, further confirming that phenytoin is a strong E2 antagonist. Conclusions: At clinically effective concentrations, phenytoin is a strong ERα cell antagonist but a many-fold weaker agonist. Although it interacts with ERβ LBD residues, phenytoin has no effects on ERβ-only expressing cells. Docking studies indicate phenytoin interacts with the ERα LBD at the hinge of helix 12 and could thereby interfere with the entry of other ER ligands or with the mobility of helix 12, either of which actions could explain phenytoin’s antagonism of ER-mediated E2 actions. Our results suggest an explanation for the broad profile of phenytoin’s actions and raise possibilities for the use of phenytoin or congeners in the clinical management of ERα-dependent conditions.
Real-time camera tracking using a particle filter and multiple feature trackers

Real-time camera tracking is steadily gaining in importance due to the drive from various applications, such as AR(Augmented Reality), human-machine interface, and ubiquitous computing. However, a real-time camera tracking using a single camera in an unknown environment is not a trivial work. In this paper, we describe a real-time camera tracking framework specifically designed to track a monocular camera in a desktop workspace. Basic idea of the proposed scheme is that a particle filter-based camera tracking is linked to multiple feature trackers for the feature mapping via measurement covariances. Moreover, we split the camera tracking and feature mapping into two separate tasks, and they are handled in two parallel processes. We demonstrate the effectiveness of the proposed approach within a desktop environment in real-time. It can be applicable to an augmented reality-based gaming system.
Valores relativos à competição organizacional e interações entre stakeholders

Os desafios que se impoem ao planeta neste inicio de seculo XXI, requerem das organizacoes um novo olhar sobre seu funcionamento e as consequencias de suas atividades, como vem apontando autores de diferentes areas das ciencias humanas e sociais. As organizacoes agem em seu cotidiano por meio de seus stakeholders, que se relacionam em interacoes mediadas por linguagem, de forma estrategica ou comunicativa, visando a obtencao de recursos necessarios a sua participacao em ambientes competitivos. Um dos aspectos que subjazem as acoes de entidades sociais sao valores. Definimos valores relativos a competicao organizacional (VRCO) como crencas socialmente construidas, que possuem significado para um individuo ou grupo, que consistem em principios-meta, que orientam as acoes sociais entre stakeholders, visando a obtencao de recursos em ambiente competitivo. Este estudo visou compreender como os VRCO se reproduzem nas interacoes entre stakeholders de organizacoes que atuam em economia de mercado. A pesquisa foi realizada sob a otica da psicologia social sociologica, mediante a abordagem do interacionismo simbolico, em uma das maiores empresas coligadas ao projeto da Economia de Comunhao na liberdade (EdC), no Brasil. Configurando um estudo de caso, de natureza exploratorio-descritivo-explicativa, os dados foram coletados mediante entrevistas, observacao participante, conversas espontâneas e documentos, e a analise e interpretacao dos resultados, inspiradas na pragmatica e na hermeneutica. Vis-a-vis o recorte teorico, os resultados sugerem os valores relativos a competicao organizacional como sendo fruto da busca de equilibrio dinâmico entre as visoes de mundo do fundador − do mundo como deveria ser e do mundo como ele e − e, as necessidades da organizacao, ora privilegiando acoes estrategicas, ora baseadas em entendimento. Os VRCO foram definidos em funcao de diferentes stakeholders, revelando anti-valores e, ao mesmo tempo em que sao produzidos nas interacoes, reproduzem os aspectos culturais das sociedades das quais os stakeholders fazem parte.
Evaluation of validity of the new diabetic foot ulcer assessment scale in Indonesia

We developed a new assessment tool for diabetic foot ulcers because no such tool specifically for diabetic foot ulcer exists. The diabetic foot ulcer assessment scale (DFUAS) has 11 domain items. The minimum and maximum scores on this scale are 0 and 98, respectively; higher scores indicate more severe wounds. The aim of this study was to evaluate the concurrent validity, construct validity and predictive validity of DFUAS in Indonesia. A prospective cohort study was conducted on patients with diabetic foot ulcer at Kitamura wound clinic in Indonesia. A total of 62 patients with 70 diabetic foot ulcers were assessed with DFUAS tool, Bates‐Jensen wound assessment tool (BWAT), and pressure ulcer scale for healing (PUSH). Concurrent validity was determined by correlation of the DFUAS total score with the external criterion (BWAT, PUSH, and wound surface area). A comparison between the total DFUAS score and chronic wound status was made to determine construct validity. We also analyzed 41 wounds that were followed for 4 weeks to evaluate predictive validity. The correlation coefficient total scores of the DFUAS against the BWAT, PUSH, and wound surface area were 0.92, 0.87, and 0.82, respectively. The comparison of the total DFUAS score with chronic wound status was p < 0.001. The predictive validity test indicated that a DFUAS cutoff score of 12 produced the best balance of sensitivity, specificity, positive predictive value, and negative predictive value (89%, 71%, 86%, and 77%, respectively). In conclusion, the newly developed DFUAS is a valid tool for assessing diabetic foot ulcers.
Interrater reliability of drug-induced sleep endoscopy.

OBJECTIVE To determine the interrater reliability of drug-induced sleep endoscopy (DISE). DESIGN Prospective cohort; blinded comparison. SETTING Academic referral center. PARTICIPANTS Subjects with obstructive sleep apnea unable to tolerate positive airway pressure therapy. INTERVENTIONS Drug-induced sleep endoscopy was performed with intravenous propofol infusion to achieve sedation, and the videoendoscopy recording was evaluated by 2 independent reviewers. MAIN OUTCOME MEASURES The following outcomes were measured: a global assessment of obstruction at the palate and/or hypopharynx; the degree of obstruction at the palate and hypopharynx; and the contribution of individual structures (palate, tonsils, tongue, epiglottis, and lateral pharyngeal walls) to obstruction. RESULTS A total of 108 subjects underwent DISE examination. Diagnostic sleep studies demonstrated a mean (SD) apnea-hypopnea index of 39.6 (24.0). Three-quarters of the subjects demonstrated multilevel airway obstruction at the palate and hypopharynx, with a diversity of individual structures contributing to obstruction. The interrater reliability for the presence of obstruction at the palate and hypopharynx (kappa values, 0.76 and 0.79, respectively) was higher than for the degree of obstruction (weighted kappa values, 0.60 and 0.44). The interrater reliability for the assessment of primary structures contributing to obstruction at the palate and hypopharynx (0.70 and 0.86) was higher than for the contributions of individual structures (kappa values, 0.42-0.71). The interrater reliability for evaluation of the hypopharyngeal structures was higher than for those of the palate region. CONCLUSION The interrater reliability of DISE is moderate to substantial. Trial Registration clinicaltrials.gov Identifier: NCT00695214.
Determinação de fatores de cocção em preparações

O Fator de Coccao (FCC) e um indicador culinario que determina o rendimento de uma preparacao, permitindo definir a capacidade dos utensilios e/ou equipamentos que serao utilizados para o preparo de uma receita, tambem determinando a porcao da preparacao, e auxiliando na lista de compras. Apesar de existirem trabalhos sobre FCC de alimentos, poucos estudos determinaram esse indicador de receitas. Assim, este trabalho teve como objetivo determinar os FCC de diferentes preparacoes. Foi realizado um estudo descritivo a partir dos dados de FCC de 66 preparacoes classificadas como cereais e leguminosas (n=32), carnes (n=14), frutas e hortalicas (n=7) e bolos e sobremesas (n=13), obtidos a partir de 487 Fichas Tecnicas de Preparo (FTP), produzidas entre 2010 a 2015 no Laboratorio de Tecnica Dietetica da UFRN. Os FCC foram avaliados em graficos Box plots e os valores extremos foram excluidos, em seguida submetidos a analise estatistica utilizando o programa Statistical Package for Social Sciences versao 11.5 (SPSS Inc. Chicago, IL). Os dados foram analisados quanto a sua normalidade utilizando o teste de Kolmogorov-smirnov. Aqueles com distribuicao normal foram apresentados como media (dp) e intervalo de confianca de 95% (IC 95%). Os dados nao parametricos foram apresentados como mediana (distância interquartil) e valor maximo e minimo. As preparacoes a base de carnes, frutas e hortalicas, bolos e sobremesas apresentaram FCC 2 indicando ganhos de massa por incorporacao de agua. O estudo definiu valores para FCC de diversas preparacoes, o que viabiliza a definicao do rendimento das preparacoes, gerando dados que podem auxiliar novas UANs no manejo dos itens citados.
Current management of facial fractures in the preadolescent

Purpose of reviewThis article reviews the trends in management of preadolescent facial fractures – a challenging population because of the need to consider growth, dynamic changes in dentition, and evolving fracture patterns. Recent findingsRecent findings are a more thorough understanding of fracture patterns and distribution because of recent comprehensive studies isolating the preadolescent age cohort; the role of rigid internal fixation for significantly displaced fractures; and the potential applications and indications for the use of resorbable hardware for fracture fixation in the preadolescent. SummaryAs preadolescent fractures occur in a period of growth and evolving dentition in the facial skeleton, it is mandatory for the treating surgeon to have a thorough knowledge of standard and alternative treatment options to optimally manage these patients.
Integrated Governance of IT Services for Value Oriented Organizations

This paper shows a latest generation model for the management and governance of the technologies and Information Systems (IT) in the organizations. IT governance is the key to achieve high level of maturity in the SOA Maturity Model. Currently there are standards and methodologies of international character that cover in detail the different critical aspects of the Information Technologies’ governance such as CobiT, Itil, ISO20000 and Balanced Scorecard for IT. This governance model starts from the knowledge acquired in the mentioned standards and allows carrying out the tacit and strategic governance of all the activities in an information systems department. The model depicted in this paper includes: the monthly and tacit control of the IT processes, the system’s portfolio management, the IT strategy planning and the alignment of the strategies with the operations (four alignments because considers: systems and business). This model is called IG4 (Information Governance Four Generation) due to the fact that it includes important improvements on the classic management and governance IT models.
Effect of a general practitioner's consulting style on patients' satisfaction: a controlled study.

OBJECTIVE--To compare the effect of directing and sharing styles of consultation by a general practitioner on patients' satisfaction with the consultation. DESIGN--Patients were randomised to receive a directing or sharing style in the part of the consultation concerned with giving treatment, advice, and prognosis. SETTING--An inner London general practice. PATIENTS--359 Randomly selected patients consulting with one general practitioner. Four patients refused to participate and five were excluded. Thirty failed to complete the initial assessment and 110 failed to complete the assessment a week later, giving response rates of 89% and 58% respectively. MAIN OUTCOME MEASURES--Patients' satisfaction with the general practitioner's perceived understanding of their problem and the explanation they received and whether they felt that they had been helped immediately after the consultation and one week later. RESULTS--Patients who had the directing style of consultation reported significantly higher levels of satisfaction on almost all the outcome measures. This was particularly striking for patients with physical problems (excellent explanation 23/68 (34%) v 10/65 (15%), p less than 0.02; excellent understanding 25/68 (37%) v 9/66 (14%), p = 0.004), and for patients who received a prescription (excellent explanation 20/60 (33%) v 9/59 (15%), p less than 0.04; excellent understanding 27/60 (45%) v 10/59 (17%), p = 0.04). There was no significant difference in the responses to the directing and sharing styles in longer consultations (8/31 (26%) v 8/31 (26%)), in which the main treatment was advice (10/30 (33%) v 7/36 (19%)), and among patients with psychological (6/17 (35%) v 6/27 (22%)) or chronic problems (14/28 (50%) v 8/32 (25%)). CONCLUSIONS--Style of consultation does influence the satisfaction of the patient, but its effect is most noticeable in consultations with patients with physical problems and patients who receive a prescription.