Miracle-dz/UniFAR-FTUs huggingface dataset:
Orally disintegrating tablets : formulation, preparation techniques and evaluation.

Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. Formulation of a convenient dosage form for oral administration, by considering swallowing difficulty especially in case of geriatric and pediatric patient leads to poor patient compliance. To troubleshoot such problems a new dosage form known as orally disintegrating tablet (ODT), has been developed which rapidly disintegrate & dissolve in saliva and then easily swallowed without need of water which is a major benefit over conventional dosage form. In addition, patients suffering from dysphasia, motion sickness, repeated emesis and mental disorders prefer such preparation because they cannot swallow large quantity of water. Further, drugs exhibiting satisfactory absorption from the oral mucosa or intended for immediate pharmacological action can be advantageously formulated in such type of dosage form. The popularity and usefulness of the formulation resulted in development of several ODT technologies for preparation. The current article is focused on ideal characteristics, advantages and disadvantages, formulation aspects, formulation technologies, evaluation of products and future potential. Various marketed preparations along with numerous scientific advancements made so far in this avenue have also been discussed.
Benchmarking platform for ligand-based virtual screening

Virtual screening (VS) of databases of chemical compounds has become a common step in the drug discovery process. Ligand-based virtual screening is a variant of VS where similarity to known active compounds is utilized in the discovery of new bioactive molecules. The cornerstone, which determines success of virtual screening, is the used molecular similarity measure. Currently, there is no superior approach to modeling molecular similarity and design of new similarity approaches is an active research field in cheminformatics. Therefore, proper benchmarking is of utter importance. In this paper, we describe common pitfalls of current approach to benchmarking of new methods. We focus on the importance of reproducibility and design of benchmarking datasets. Moreover, we identify the dataset difficulty as an important, yet not wildly utilized, property of the benchmarking data. To solve the identified issues we present a new benchmarking platform. The platform implements most commonly used molecular representations and includes datasets of varying difficulty levels as well as scripts which make the platform easy to use and extend. The existing representations are benchmarked using the proposed platform and results are presented. The benchmarking platform is available at https://github.com/skodapetr/lbvs-environment.
Productivity spillovers in the GVC: The case of Poland and the New EU Member States

The new EU member states have been experiencing firm internationalization not only through inward foreign direct investment but also through exporting, importation of foreign technology in investment goods and increased use of imported intermediates. We argue that there are important productivity spillovers within the global value chains, i.e. FDI alone does not tell the whole story of the reallocation processes going on in the economies of the NMS. We augment the standard TFP spillover empirical model with modern measures of GVC participation. We show that increased foreign content of exports brings additional productivity gains on top of the ones attributed to exporting. Moreover, we show that in selected cases, participation in the GVC leads to a smaller productivity gap between foreign and domestic firms.
The Efficiency Boom: Cashing In on the Savings from Appliance Standards

Appliance, equipment, and lighting standards have been a cornerstone of U.S. energy policy since Congress enacted the first standards in the 1980s. They have significantly reduced U.S. energy consumption, providing large economic benefits for consumers and businesses. Taking into account products sold from the inception of each national standard through 2035, existing standards will net consumers and businesses more than $1.1 trillion in savings cumulatively. By 2035, cumulative energy savings will reach more than 200 quads, an amount equal to about two years of total U.S. energy consumption.
Serum AOPP , selenium and vitamin E levels after irradiation

Radiation injury to living cells is, to large extent, due to oxidative stress (1). However, irradiation also damages non-target cell or tissue. Free radicals and reactive oxygen species (ROS) react with DNA, lipids, proteins, carbohydrates and damage them. Nevertheless, organisms have protective systems against free radical reactions such as antioxidants and antioxidative enzymes. Antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase and non-enzymatic antioxidants such as vitamin E and selenium offer protection against ionizing radiation induced oxidants (2,3).
Comparing Meaning in Language and Cognition : P-Hyponymy , Concept Combination , Asymmetric Similarity Candidate

In this dissertation we work in the framework of compositional distributional models of meaning to examine a number of asymmetric linguistic phenomena that manifest themselves in language and cognition. These include overextension with respect to concept combination, asymmetry of similarity judgment and hyponymy and typicality. In particular, we make use of the formalism of density matrices, which were recently introduced as an alternative to the vector-based model of word meaning. We first consider the former two of the above-mentioned phenomena using only tools that have been developed so far in the distributional compositional model. We then proceed to define a new quantitative asymmetric measure on density matrices, called p-hyponymy, which allows us to determine the strength of hyponymy in hyponym-hypernym pairs. We show how this can be lifted to the level of the sentence structures that our mathematical model of meaning supports and consider the implications of this result. We conclude with a brief discussion of how this measure can potentially be modified to account for other similar phenomena.
Application of Web-based Knowledge Management Systems in The Mineral Industry

Knowledge Management has been shown to benefit many large corporate companies by using the intellectual capital of the firm. The data, information and knowledge captured in a firm in terms of explicit and tacit knowledge can be used to gain competitive advantage. The use of electronic information systems using corporate intranets and the Internet can help facilitate the management of knowledge in terms of sharing best practise, globalisation, rapid change in technology, downsizing, managing information and communica­ tion overload experienced by many companies. The paper discusses the application of web-based intranets linked to knowledge management systems to provide codification of knowledge and models for converting this knowledge into a corporate resource. A case study to demonstrate the application of multimedia using metaphors, models and narratives to exchange and synthesise knowledge is discussed with reference to the minerals industry.
The Influence of Economic Value Added On Liability Management in Commercial Banks of Indonesia

Research aims: (1) to observe and to analyze the influence of EVA, as reflected by economic value added of banking firms, on liability management (LM) in commercial banks of Indonesia; (2) to investigate and to analyze the influence of asset-liability management (ALM) consisting of Rate Sensitivity Asset to Rate Sensitivi ty Liability (RSA/RSL), Net Interest Margin (NIM), Capital Asset Ratio (CAR), Burden Ratio, Return on Asset (ROA), Loan Accepted to Asset Total, Non-Interest Income to Asset Total, and Loan to Deposit Ratio (LDR), on EVA in commercial banks of Indonesia; (3) to examine and to analyze the influence of EVA, as reflected by economic value added of banking firms, on asset-liability management (ALM) in commercial banks of Indonesia. Research type is explanatory. Data analysis is using methods developed by Ferdinand (2002)[1], Solimun (2003)[2], and Anderson, Tatham and Black (1992)[3]. Result of research indicates that: (1) The influence of EVA on LM in commercial banks of Indonesia based on information of goodness of fit index, is not showing good result on criteria evaluation because the hypothesized model is unidentified (identification problem). It means that causal line that explains causality relation between variables is not supported by the fact , and thus, information matrix is failed to present and also unable to explain causality relation between variables. (2) The influence of ALM on EVA in commercial banks of Indonesia is also showing good result on criteria evaluation because the causal line explaining causality relation between factors is supported by the facts. Its positive significant influence is proved by score 0.309 at p=0.000, meaning that higher significant influence of ALM will increase banking value added creation by using Economic Value Added (EVA). It implies that banking financial performance shown by ALM is the measure of banking success. If banking financial performance is good, investors will be willing to pay prices of banking stock in various times than earning per share through multiplier effect. This effect may be seen in the value added creation of commercial banks of Indonesia. ALM indicator in form of net interest margin (NIM) is the most dominant influential to EVA by score 0.997 at p=0.000. It means that the selection of ALM to reflect bank ability to manage fund sources into prof itable asset, measured by NIM, is the best option which contributes to the increase of banking firms’ value added creation by using EVA proxy of commercial banks of Indonesia; and (3) The influence of EVA on ALM in commercial banks of Indonesia, based on the information of goodness of fit index, does not show good result on criteria evaluation because the hypothesized model is unidentified (identification problem). It means that causal line that explains causality relation between variables is not supported by the fact, and thus, information matrix is failed to present and also unable to explain causality relation between variables.
Key success factors in national it infrastructure projects: A study of a nationwide e-business initiative

The role of information technology has become a key driver in cost efficiency measures. In order to achieve that goal however, it is vital that systems are kept simple and interoperability is king. That is the reason why some countries have begun introducing and even mandating national IT standards. This paper focuses on the implementation of such standards for e-business in the Nordic countries. It will try to establish the best practices and must-avoid mistakes in such implementation in the hope that it will be of value to the countries that have yet to follow the e-invoicing trend.
Does Consumers' Product-Related Involvement Matter When it Comes to Corporate Ads?

Abstract The study reported in this article examines the effects of three involvement types (technology, computer product category, and advertisement involvements) on attitude/behavioral intentions in two contexts: product and corporate ads. Specifically, the study explored these relationships using computer product ads and the ads of the company that produces the computer brand featured in the product ads. In the corporate ads, involvement levels in the technology and computer product category did not reveal a significant influence, whereas all three involvement types (technology, computer product category, and advertisement involvement) had a significant influence on attitudes and behavioral intentions of viewers in the product ads. The results suggest that consumers' product related involvements might not have the same influences on the corporate ads as the product ads.
Repeatability of the endurance shuttle walk test in people with chronic obstructive pulmonary disease

Walking tests, including the endurance shuttle walk test (ESWT), have been used to assess functional capacity in people with chronic obstructive pulmonary disease (COPD). Learning effects through repeated practice have been reported for some field walking tests. However, the repeatability of ESWT at various time points, i.e. within the same day, within the week and one week apart, has not been examined.
What Chinese cruisers want: An analysis of product preferences

Yaming, Yang. M.S., Purdue University, May 2015. What Chinese Cruisers Want: An Analysis of Product Preferences. Major Professors: Howard Adler and Xinran Lehto. Cruise travel has become increasingly popular, and the number of cruisers is growing rapidly. China plays a dominant role in worldwide tourism owing to its large population and fast economic development. It is a potential major market for the cruise industry. The number of inbound and outbound Chinese travelers continues to increase, generating growing interest in cruise travel. Investigating what Chinese cruisers want from cruise travel has great significance; however, little research has been conducted conc product preferences. This study also features an exploratory analysis on motivational factors in a Chinese context. Theoretical and practical implications are discussed.
Sympathetic activity and presynaptic adrenoceptor function in patients with longstanding essential hypertension.

OBJECTIVE To assess the contribution of the sympathetic nervous system to the hypertension in patients with longstanding essential hypertension. DESIGN Overall sympathetic function, presynaptic adrenoceptors and neuronal re-uptake were examined after withdrawal of medication for at least 3 weeks in eight patients with longstanding essential hypertension and in eight carefully matched normotensive control subjects. METHODS Minimal forearm vascular resistance after 10 min ischaemia was used as a measure of structural vascular changes. Overall sympathetic tone was assessed using tilt testing and pressor dose infusion of noradrenaline. The presence and function of presynaptic adrenoceptors and the neuronal re-uptake of noradrenaline were evaluated in the forearm using tracer noradrenaline kinetics with measurement of forearm noradrenaline plasma appearance rate and noradrenaline plasma spillover. Intra-arterial infusions of tritiated noradrenaline, the endogenous alpha- and beta-adrenoceptor agonist adrenaline, the alpha-adrenoceptor blocker phentolamine, the non-adrenergic vasodilator sodium nitroprusside and the neuronal re-uptake inhibitor desipramine were given in the forearm. RESULTS We found that the hypertensives had higher minimal forearm vascular resistance, indicating structural vascular changes; decreased overall sympathetic activity, indicated by a lower basal whole-body noradrenaline production rate; enhanced vasopressor sensitivity for exogenously administered noradrenaline with decreased arterial baroreflex sensitivity; indications of decreased forearm neuronal re-uptake; evidence consistent with the presence of presynaptic, release-facilitating beta-adrenoceptors in the forearm, apparently not functionally different between the two groups; and undecisive evidence for the presence of functional presynaptic alpha-adrenoceptors in the forearm. CONCLUSIONS In patients with longstanding essential hypertension we found decreased overall sympathetic activity, with indications of decreased forearm neuronal re-uptake, which might have a compensatory role. We found indications of structural vascular changes and diminished baroreflex sensitivity in the hypertensives, which contribute to the hypertension. However, peripheral presynaptic, release-facilitating beta-adrenoceptors seem to be present, which are functionally not clearly different between the two groups. Observations on peripheral presynaptic alpha-adrenoceptors were inconclusive.
A supply chain study of technology trust and antecedents to technology internalization consequences

Purpose – User uncertainty and risk are inherent in any technology adoption due to the perceived long‐term consequences (LTC) associated with the internalization process. This study seeks to investigate antecedents of technology trust (TT) and perceived LTC associated with using a technology in order to understand the underlying attitudes and beliefs influencing supply chain members' trust in a specific information technology (IT). Design/methodology/approach – A theoretical model was tested through a survey of 449 supply chain members using an IT innovation for part‐level visibility along the entire first‐tier of a major US automotive supply chain.Findings – Empirical results confirm the basic structure of the model, including the role of TT impacting users' perceptions of LTC relative to internalizing the technology. Results also identify several uncertainty reducing antecedents of TT and perceived LTC including satisfaction with the existing system, task‐technology fit, and prior similar experiences.Res.
Social e-entrepreneurship and technological innovations: the role of online communities, mobile communication and social networks

Social entrepreneurship has been a growing area of interest for businesses that want to include a not-for-profit perspective in addition to their profit orientation as part of their overall strategy. The increasing integration of technology within a business’s strategy has lead to the development of social electronic enterprises (e-enterprises), which involve a business having a social purpose in the online environment. Social e-enterprises enable the use of technological innovations as a way for business to creatively solve social issues. The purpose of this paper is to explore how social e-enterprises are being used in order to facilitate better usage of mobile communication and online communities. This is helped by a focus on the opportunity recognition of social entrepreneurship made possible by technological innovations that have linked the global business environment. As more businesses utilise emerging technology, this has shaped the way that social e-enterprises are functioning. This paper will review the nascent literature on social entrepreneurship with a focus on how the e-entrepreneurship has emerged. Suggestions for practitioners involved in shaping social e-enterprises are stated with recommendations for future research.
Perceived Gender Classification from Face Images

Perceiving human faces and modeling the distinctive features of human faces that contribute most towards face recognition are some of the challenges faced by computer vision and psychophysics researchers. There are many methods have been proposed in the literature for the facial features and gender classification. However, all of them have still disadvantage such as not complete reflection about face structure, face texture. The features set is applied to three different applications: face recognition, facial expressions recognition and gender classification, which produced the reasonable results in all database. In this paper described two phases such as feature extraction phase and classification phase. The proposed system produced very promising recognition rates for our applications with same set of features and classifiers. The system is also real- time capable and automatic.
Customer Acceptance of Internet Banking Services: A Review of Extensions and Replications to Technology Adoption Model (TAM)

This paper is aimed to critically appraise the extensions and replications to technology acceptance model (TAM) in the context of internet banking services. In order to compile the various constructs used in the models, twenty existing models have been examined from the point of view of the relevance and importance of consumer’s acceptance of Internet Banking in the various cultural contexts. The study highlights the limitations of all these existing models of internet banking technology adoption. Examination of the extended models shows that TAM has wide applicability across varied cultures and countries. The current development of the knowledge base on internet banking adoption models has led to analysis of key dimensions, which have significant impact on user behaviour, across various countries and cultures. Further, study shows that risk, trust, efficacy, and social influence are important stimulators of cognitive beliefs. Hence bank management need to develop more advanced approach to overcome the perceived risk of using internet banking, also effective communication will build consumers trust in bank. The study provides knowledge base for bank management to understand the individual predictors of internet banking, particularly in case of developing countries. Examination of individual predictors of internet banking in country and cultural context will enable bank management to formulate strategies and policies, to expand their customer base in addition to offering internet banking services. And research directions are provided for potential researchers in the area.
Assessment of Cost Uncertainties for Large Technology Projects: A Methodology and an Application

Large projects, especially those planned and managed by government agencies, often incur substantial cost overruns. The tolerance, particularly on the part of members of Congress, for these cost overruns has decreased, thus increasing the need for accurate, defensible cost estimates. Important aspects of creating responsible cost estimates are accounting for the uncertainties in these estimates, expressing the estimates clearly, and communicating them to decision makers. Our method for estimating cost uncertainties can be used at all stages of a project. It combines the principles of probabilistic risk analysis with procedures for expert elicitation to incorporate uncertainties and extraordinary events in cost estimates. The Department of Energy implemented this process to select a new tritium supply source. During this implementation, we identified four key issues in modeling cost risks: how to consider correlations among cost components, how to aggregate assessments of multiple experts, how to manage communication and information sharing among experts, and what is an appropriate discount rate for cost estimates.
Fast quantum modular exponentiation architecture for Shor's factoring algorithm

We present a novel and efficient, in terms of circuit depth, design for Shor's quantum factorization algorithm. The circuit effectively utilizes a diverse set of adders based on the Quantum Fourier transform (QFT) Draper's adders to build more complex arithmetic blocks: quantum multiplier/accumulators by constants and quantum dividers by constants. These arithmetic blocks are effectively architected into a quantum modular multiplier which is the fundamental block for the modular exponentiation circuit, the most computational intensive part of Shor's algorithm. The proposed modular exponentiation circuit has a depth of about 2000n2 and requires 9n + 2 qubits, where n is the number of bits of the classic number to be factored. The total quantum cost of the proposed design is 1600n3. The circuit depth can be further decreased by more than three times if the approximate QFT implementation of each adder unit is exploited.
The application of acetolysis for releasing leaf cuticular membranes of Pandanus in taxonomic studies.

Leaf cuticular membranes can be released cleanly and in one piece after a 10 min treatment of leaf in a 100 C acetolysis mixture: acetic anhydride, 9; and concentrated H2SO4,1 v/v. This method has been used till now only for studying pollen and spore morphology but was found quite appropriate for a taxonomic study of the leaf surface of the genus Pandanus.