Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling transdisciplinary cooperation in the agriculture sector for European Innovation Partnerships.

European Innovation Partnerships (EIPs) are a new instrument to promote innovations and to overcome sector specific gaps in technology transfer. Particularly in the present day agriculture sector, there is a strong perception of a valley-of-death in innovation processes. This study had the overall objective to develop a model for transdisciplinary cooperation and innovation brokerage on the federal level of Brandenburg in Germany in the pre-implementation phase of EIP. The formative approach combined two methodological streams: first we adapted a stagegate-process elaborated initially for product optimization in industry. Secondly, we framed a design for business model development. The process aimed to 1. identify innovation gaps, 2. assess political and socio-economic frame conditions, and 3. investigate structural elements for a pilot innovation network. The gates were used to validate the results with regional stakeholders’ requirements. The process revealed a need for organisational innovations atop of technical or service innovations. We therefore developed a model structure for formal collaboration targeting the innovation capacity within the regional agriculture sector and validated the potential modes of operation against a set of predefined criteria. We highlight the significance of undertaking regular calibration with the evolving policy planning at higher levels and the necessity for permanent translation to the context of regional stakeholders. The effort to form new organisations can be supported by methods from ex ante policy assessment and business model development. The function of innovation brokerage can be integrated into a newly formed innovation network if this function is not sufficiently provided for by existing organisations.
A Combinatorial Code for Gene Expression Generated by Transcription Factor Bach2 and MAZR (MAZ-Related Factor) through the BTB/POZ Domain

ABSTRACT Bach2 is a B-cell- and neuron-specific transcription repressor that forms heterodimers with the Maf-related oncoproteins. We show here that Bach2 activates transcription by interacting with its novel partner MAZR. MAZR was isolated by the yeast two-hybrid screen using the BTB/POZ domain of Bach2 as bait. Besides the BTB/POZ domain, MAZR possesses Zn finger motifs that are closely related to those of the Myc-associated Zn finger (MAZ) protein. MAZR mRNA was coexpressed with Bach2 in B cells among hematopoietic cells and in developing mouse limb buds, suggesting a cooperative role for MAZR and Bach2 in these cells. MAZR forms homo- and hetero-oligomers with Bach2 through the BTB domain, which oligomers bind to guanine-rich sequences. Unlike MAZ, MAZR functioned as a strong activator of the c-myc promoter in transfection assays with B cells. However, it does not possess a typical activation domain, suggesting a role for it as an unusual type of transactivator. The fgf4 gene, which regulates morphogenesis of limb buds, contains both guanine-rich sequences and a Bach2 binding site in its regulatory region. In transfection assays using fibroblast cells, the fgf4 gene was upregulated in the presence of both MAZR and Bach2 in a BTB/POZ domain-dependent manner. The results provide a new perspective on the function of BTB/POZ domain factors and indicate that BTB/POZ domain-mediated oligomers of transcription factors may serve as combinatorial codes for gene expression.
WAGES, GOVERNMENT PAYMENTS AND OTHER INCOME OF INDIGENOUS AND NON-INDIGENOUS AUSTRALIANS

This paper compares the level and source of income for Indigenous and non- Indigenous Australians using data from the 2011 wave of the Household Income and Labour Dynamics in Australia (HILDA). Three sources of income are considered: wages and salaries; government benefits; and income from businesses, investments and other private transfers. Consistent with many previous studies, Indigenous Australians have, on average, lower total income than non-Indigenous Australians, with this difference being largest for those who are full-time employed. The difference is also larger for males compared to females. In terms of non-wage income, Indigenous men and women receive a much smaller proportion of income from other sources than their non-Indigenous counterparts (primarily business and investment income). This is particularly the case for those who are not in the labour force (NILF). Correspondingly, government benefits constitute a higher proportion of income for the Indigenous population than for the non-Indigenous. This is true for both males and females, and for all labour force states, although the difference is largest for part-time employed and those who are NILF. Given Indigenous persons are also more likely to be unemployed than non-Indigenous persons, they are more likely to be dependent solely on government payments as a source of income at any one time. The implications of these findings are discussed, as well as directions for future research.
Longitudinal Effects of Early Childhood Maltreatment on Co-Occurring Substance Misuse and Mental Health Problems in Adulthood: The Role of Adolescent Alcohol Use and Depression.

OBJECTIVE This study tested a developmental model in which subtypes of childhood maltreatment were hypothesized to have direct and indirect effects on co-occurring depression, anxiety, and substance misuse in adulthood. Indirect effects involved adolescent alcohol use and depression, which were included as mediators in the tested models. METHOD This prospective longitudinal study (N = 332; 52.4% male) followed the participants from childhood (18 months to 6 years of age) to adulthood (31-41 years old, M = 36.21). Maltreatment subtypes included parent-reported physical and emotional abuse and child-reported sexual abuse. Adult outcomes included measures of substance misuse and mental health (i.e., depression and anxiety). Latent class analysis and structural equation models were used to identify classes of substance misuse and mental health co-occurrence and to test mediating effects of adolescent alcohol use and depression. RESULTS Three classes were identified: (a) low risk of substance misuse and low mental health symptoms, (b) moderate substance misuse risk and mild depression and anxiety, and (c) moderate substance misuse risk and moderate to high depression and anxiety. Structural models showed that effects of childhood sexual abuse were fully mediated by adolescent alcohol use and depression. Physical abuse increased adolescent depression but did not have direct or indirect effects on adult outcome classes. Emotional abuse had a direct effect on the adult classes. CONCLUSIONS Children exposed to severe emotional abuse are at higher risk for comorbid substance misuse, depression, and anxiety into their mid-30s, after taking into account evidence of alcohol use and depression during adolescence. Sexual and physical abuse have more proximal effects on adolescent alcohol use and depression, which then influence the risk of adult problems.
Characterization of secondary aerosol and its extinction effects on visibility over the Pearl River Delta Region, China

Aerosol samples collected from July 2007 to March 2008 were used to obtain major aerosol constituents in an urban location in the Pearl River Delta Region (PRD), China. The minimum organic carbon (OC)/elemental carbon (EC) ratio was used to calculate the primary and secondary organic carbon and the extinction effect of the secondary aerosol on visibility was estimated. As indicated in the analysis, the mass of secondary aerosol takes up 50% of the total mass of PM2.5; the OC/EC ratio is larger than 2 and there are significant characteristics of secondary aerosol generation; the levels of secondary OC are comparable with those of sulfate; and there is obvious enrichment of secondary aerosol on more polluted days. In a dry environment, the extinction weight is 59% for the secondary aerosol, while it is as high as 82% if the environment is highly humid (relative humidity [RH] = 95%). The hygroscopic growth of the aerosol can reduce visibility greatly; the secondary aerosol shares much larger quotas on more polluted days. For the Pearl River Delta (PRD), secondary aerosol and carbonaceous aerosol, especially secondary organic carbon (SOC), are a very acute problem; the study of the generating mechanism and sources for secondary aerosol is the key to the effort of controlling visibility in this region. The equation set forth in IMPROVE experiments can only be referenced but is not applicable to evaluate the extinction effect of individual aerosol components on visibility in the PRD region. Implications: The extinction effects on visibility by different constituents are studied in this work using compositional data derived from the measurements, with special efforts on examining the extinction of secondary aerosol and the enrichment and extinction contributions of the constituents with the variation of pollution level and relative humidity, so as to provide a scientific basis for the mitigation of atmospheric aerosol pollution and improving visibility in the PRD of China.
An efficient certificate revocation validation scheme with k-means clustering for vehicular ad hoc networks

Vehicular ad hoc networks (VANETs) are emerging as a promising approach to improve traffic safety and provide a wide range of wireless applications to passengers in vehicles. To launch reliable and trusted vehicular communications, one prerequisite is to ensure peer vehicles' credibility, by means of digital certificate validation from messages that are sent out by other vehicles. However, in vehicular communication systems, certificate validation is more time sensitive than in traditional networks, because each vehicle receives a large number of messages in a short period of time. Another issue that needs to be tackled is the unsuccessful delivery of information between vehicles and other entities on the road due to their high rate of mobility. For these reasons, we need new solutions to speed up the process of certificate validation. In this article, we propose a certificate revocation status validation scheme; this uses the concept of clustering in the realm of data mining, which can meet the aforementioned requirements. We employ the technique of k-means clustering to boost up the efficiency of certificate validation, thereby enhancing the security of VANETs. Additionally, a comprehensive analysis in terms of security for the scheme is presented; and the analytical results demonstrate that this scheme can effectively improve the validation of a certificate, thus securing the vehicular communication in vehicular networks.
Equity Home Bias and Regret: An International Equilibrium Model

IWe develop an equilibrium international asset pricing model assuming that investors treat foreign assets as an asset class separate from domestic assets, their core portfolio. When the foreign portfolio underperforms the domestic portfolio, investors feel regret of having invested abroad. Such an attitude could be justified by numerous behavioral heuristics often mentioned in the home bias literature. Following regret theory, investors are assumed to construct their portfolios taking simultaneously into account their aversion to risk and to regret. In equilibrium, the expected return of foreign equity relative to domestic equity is equal to that dictated by the traditional CAPM plus a regret premium. This regret premium is a function of the difference of regret aversion across investors and net foreign positions. With similar regret aversion worldwide, the traditional CAPM pricing relation holds, even though investors exhibit home bias in their portfolio holdings. In equilibrium, it is sufficient to have regret aversion in a single country to observe home bias in portfolio holdings of investors from all countries. An implication of the model is that countries with larger home bias should have lower expected return on their equity markets. The article is theoretical, but provides some model calibration and a crude and simple test that lends support to this conclusion.
CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke

Background and objective CT perfusion (CTP) is rapid and accessible for emergency ischaemic stroke diagnosis. The feasibility of introducing CTP and diagnostic accuracy versus non-contrast CT (NCCT) in a tertiary hospital were assessed. Methods All patients presenting <9 h from stroke onset or with wake-up stroke were eligible for CTP (Siemens 16-slice scanner, 2×24 mm slabs) unless they had estimated glomerular filtration rate (eGFR)<50 ml/min or diabetes with unknown eGFR. NCCT was assessed by a radiologist and stroke neurologist for early ischaemic change and hyperdense arteries. CTP was assessed for prolonged time to peak and reduced cerebral blood flow. Technical adequacy was defined as 2 CTP slabs of sufficient quality to diagnose stroke. Results Between January 2009 and September 2011, 1152 ischaemic stroke patients were admitted, 475 (41%) were <9 h/wake-up onset. Of these, 276 (58%) had CTP. Reasons for not performing CTP were diabetes with unknown eGFR (48 (10%)), known kidney disease (36 (8%)), established infarct on NCCT (27 (6%)), posterior circulation syndrome (25 (5%)) and patient motion/instability (16 (3%)). Clinician discretion excluded a further 47 (10%). CTP was more frequently diagnostic than NCCT (80% vs 50%, p<0.001). Non-diagnostic CTP was due to lacunar infarction (28 (10%)), infarct outside slab coverage (21 (8%)), technical failure (4 (1%)) and reperfusion (2 (0.7%)). Normal CTP in 86/87 patients with stroke mimics supported withholding tissue plasminogen activator. CTP technical adequacy improved from 56% to 86% (p<0.001) after the first 6 months. Median time for NCCT/CTP/arch-vertex CT angiogram (including processing and interpretation) was 12 min. No clinically significant contrast nephropathy occurred. Conclusions CTP in suspected stroke is widely applicable, rapid and increases diagnostic confidence.
Critical Role of Glu40-Ser48 Loop Linking Actuator Domain and First Transmembrane Helix of Ca2+-ATPase in Ca2+ Deocclusion and Release from ADP-insensitive Phosphoenzyme*

The functional importance of the length of the A/M1 linker (Glu40-Ser48) connecting the actuator domain and the first transmembrane helix of sarcoplasmic reticulum Ca2+-ATPase was explored by its elongation with glycine insertion at Pro42/Ala43 and Gly46/Lys47. Two or more glycine insertions at each site completely abolished ATPase activity. The isomerization of phosphoenzyme (EP) intermediate from the ADP-sensitive form (E1P) to the ADP-insensitive form (E2P) was markedly accelerated, but the decay of EP was completely blocked in these mutants. The E2P accumulated was therefore demonstrated to be E2PCa2 possessing two occluded Ca2+ ions at the transport sites, and the Ca2+ deocclusion and release into lumen were blocked in the mutants. By contrast, the hydrolysis of the Ca2+-free form of E2P produced from Pi without Ca2+ was as rapid in the mutants as in the wild type. Analysis of resistance against trypsin and proteinase K revealed that the structure of E2PCa2 accumulated is an intermediate state between E1PCa2 and the Ca2+-released E2P state. Namely in E2PCa2, the actuator domain is already largely rotated from its position in E1PCa2 and associated with the phosphorylation domain as in the Ca2+-released E2P state; however, in E2PCa2, the hydrophobic interactions among these domains and Leu119/Tyr122 on the top of second transmembrane helix are not yet formed properly. This is consistent with our previous finding that these interactions at Tyr122 are critical for formation of the Ca2+-released E2P structure. Results showed that the EP isomerization/Ca2+-release process consists of the following two steps: E1PCa2 → E2PCa2 → E2P + 2Ca2+; and the intermediate state E2PCa2 was identified for the first time. Results further indicated that the A/M1 linker with its appropriately short length, probably because of the strain imposed in E2PCa2, is critical for the correct positioning and interactions of the actuator and phosphorylation domains to cause structural changes for the Ca2+ deocclusion and release.
Detection of electrographic seizures with continuous EEG monitoring in critically ill patients

Objective: To identify patients most likely to have seizures documented on continuous EEG (cEEG) monitoring and patients who require more prolonged cEEG to record the first seizure. Methods: Five hundred seventy consecutive patients who underwent cEEG monitoring over a 6.5-year period were reviewed for the detection of subclinical seizures or evaluation of unexplained decrease in level of consciousness. Baseline demographic, clinical, and EEG findings were recorded and a multivariate logistic regression analysis performed to identify factors associated with 1) any EEG seizure activity and 2) first seizure detected after >24 hours of monitoring. Results: Seizures were detected in 19% (n = 110) of patients who underwent cEEG monitoring; the seizures were exclusively nonconvulsive in 92% (n = 101) of these patients. Among patients with seizures, 89% (n = 98) were in intensive care units at the time of monitoring. Electrographic seizures were associated with coma (odds ratio [OR] 7.7, 95% CI 4.2 to 14.2), age <18 years (OR 6.7, 95% CI 2.8 to 16.2), a history of epilepsy (OR 2.7, 95% CI 1.3 to 5.5), and convulsive seizures during the current illness prior to monitoring (OR 2.4, 95% CI 1.4 to 4.3). Seizures were detected within the first 24 hours of cEEG monitoring in 88% of all patients who would eventually have seizures detected by cEEG. In another 5% (n = 6), the first seizure was recorded on monitoring day 2, and in 7% (n = 8), the first seizure was detected after 48 hours of monitoring. Comatose patients were more likely to have their first seizure recorded after >24 hours of monitoring (20% vs 5% of noncomatose patients; OR 4.5, p = 0.018). Conclusions: CEEG monitoring detected seizure activity in 19% of patients, and the seizures were almost always nonconvulsive. Coma, age <18 years, a history of epilepsy, and convulsive seizures prior to monitoring were risk factors for electrographic seizures. Comatose patients frequently required >24 hours of monitoring to detect the first electrographic seizure.
Nanoplastic Affects Growth of S. obliquus and Reproduction of D. magna

The amount of nano- and microplastic in the aquatic environment rises due to the industrial production of plastic and the degradation of plastic into smaller particles. Concerns have been raised about their incorporation into food webs. Little is known about the fate and effects of nanoplastic, especially for the freshwater environment. In this study, effects of nano-polystyrene (nano-PS) on the growth and photosynthesis of the green alga Scenedesmus obliquus and the growth, mortality, neonate production, and malformations of the zooplankter Daphnia magna were assessed. Nano-PS reduced population growth and reduced chlorophyll concentrations in the algae. Exposed Daphnia showed a reduced body size and severe alterations in reproduction. Numbers and body size of neonates were lower, while the number of neonate malformations among neonates rose to 68% of the individuals. These effects of nano-PS were observed between 0.22 and 103 mg nano-PS/L. Malformations occurred from 30 mg of nano-PS/L onward. Such plastic concentrations are much higher than presently reported for marine waters as well as freshwater, but may eventually occur in sediment pore waters. As far as we know, these results are the first to show that direct life history shifts in algae and Daphnia populations may occur as a result of exposure to nanoplastic.
Some effects of risperidone and quetiapine on growth parameters and hormone levels in young pigtail macaques.

OBJECTIVE Atypical antipsychotic drugs are prescribed to young children for a number of symptoms, some with no Food and Drug Administration approval for children. Effects on growth of children have received little experimental study. We assessed the effects of two atypicals, risperidone and quetiapine, on growth, prolactin, and thyroid hormones of young pigtail macaques (macaca nemestrina), modeling potential effects on 4-8-year-old children. METHODS Subjects were studied blindly after random assignment to risperidone (N = 10), quetiapine (N = 10), or placebo (N = 20). Four phases were studied: (1) predrug, 9-12 months of age; (2) low dose (risperidone 0.025 mg/kg, quetiapine 2 mg/kg), 13-16 months; (3) high dose (risperidone 0.05 mg/kg, quetiapine 4 mg/kg), 17-20 months; (4) postdrug, 21-24 months. Body weight was measured daily, skeletal dimension monthly, and bone mineralization and hormones bimonthly. RESULTS Our primary result showed that, compared with placebo, neither drug had detrimental effects on body weight, skeletal dimensions, or thyroid hormones. However, in a transient effect, bone density was lower following low-dose risperidone than either quetiapine or placebo. In both drug phases, risperidone prolactin was higher than the other groups, which did not differ. The higher prolactin of the risperidone group may partially explain the bone density effect. CONCLUSION This 16-month study of young, developing pigtail macaques given risperidone at doses from 0.025 to 0.05 mg/kg or quetiapine at doses from 2 to 4 mg/kg suggests that these drugs are safe for normal body weight and skeletal growth in young pigtail macaques given an adequate diet, although these drugs are known to cause significant weight gain and other metabolic changes in some children, adolescents, and adult humans. In addition, the results, although transient in our study, also suggest that research in children on bone mineralization effects of risperidone, and possibly other antipsychotic drugs, may be warranted.
Ordered ranked weighted aggregation based book recommendation technique: A link mining approach

The intense growth of the modern technologies has caused data overload over the Internet. The increasing data over the World Wide Web has created the problems for the users to extract the exact information. The growth of the Internet has also boosted the e-commerce. The popularity of online shopping has grown up rapidly. Online shopping has become much more popular. While browsing the e-marketing portals, multiple options are presented before users; hence picking the right item is a difficult job. In this paper we propose a recommendation method for books. We have adopted link mining approach to recommend books using Ordered Ranked Weighted Averaging (ORWA) aggregation operator. ORWA is a modified form of Ordered Weighted Aggregated averaging (OWA) operator, a multi criteria decision making procedure. The weight generation using guided quantifier does not take into account the value of the voters, here, rankers which recommend the products, i.e. universities' ranking. Therefore the top ranked universities are considered and their recommended books are listed. We propose an algorithm to score the ranked books. By applying ORWA operator, best ranked books are recommended. This method may fulfill the requirement of the millions of students and academician who seek for their desired books.