Miracle-dz/UniFAR-FTUs huggingface dataset:
The evaluation of a multifaceted intervention to promote “speaking up” and strengthen interprofessional teamwork climate perceptions

ABSTRACT Communication failure is a leading cause of error and is often due to inhibition of individuals to speak up in interprofessional healthcare environments. The present study sought to evaluate the impact of a multifaceted intervention designed to promote speaking up on teamwork climate in one clinical department of a large community hospital based in Canada. The multifaceted intervention included a role-playing simulation workshop, teamwork climate data feedback and facilitated discussion with the interprofessional team (discussion briefings), and other department-led initiatives to promote trust, teamwork, and speaking up among interprofessional team members. A quasi-experiment (pretest–posttest control group design, using two posttests several months apart) was used to evaluate the impact of the complete intervention on individual teamwork climate perceptions. The intervention was implemented with an intact interprofessional team (the Emergency Department—ED) in 2014. The intensive care unit (ICU) was used as the control unit. Survey response rates were the highest at time 1 (83/102 = 81% for the ED and 29/31 = 94% for the ICU) and the lowest at time 3 (38/105 = 36% for the ED and 14/30 = 47% for the ICU). The results obtained from paired and unpaired analyses suggest that this type of multifaceted approach can improve staff perceptions of teamwork climate. The teamwork climate score in the ED was significantly higher at follow-up (Mt2 = 3.42, SD = 0.66) compared to baseline (Mt1 = 3.13, SD = 0.72), (F(1, 34) = 12.2, p = . 001, eta2p = . 263), while baseline and follow-up scores were not significantly different between baseline and follow-up for the ICU group (Mt1 = 4.12, SD = 0.60; Mt2 = 4.15, SD = 0.56; F(1, 34) = 0.06, p = . 806, eta2p = . 002). Sustaining high levels of participation in interprofessional initiatives and engaging physicians remain challenging when interventions are used in context. Improving team communication is a broad and challenging area that continues to require attention.
The RPC31 gene of Saccharomyces cerevisiae encodes a subunit of RNA polymerase C (III) with an acidic tail

The RPC31 gene encoding the C31 subunit of Saccharomyces cerevisiae RNA polymerase C (III) has been isolated, starting from a C-terminal fragment cloned on a lambda gt11 library. It is unique on the yeast genome and lies on the left arm of chromosome XIV, very close to a NotI site. Its coding sequence perfectly matches the amino acid sequence of two oligopeptides prepared from purified C31. It is also identical to the ACP2 gene previously described as encoding an HMG1-like protein (W. Haggren and D. Kolodrubetz, Mol. Cell. Biol. 8:1282-1289, 1988). Thus, ACP2 and RPC31 are allelic and encode a subunit of RNA polymerase C. The c31 protein has a highly acidic C-terminal tail also found in several other chromatin-interacting proteins, including animal HMG1. Outside this domain, however, there is no appreciable homology to any known protein. The growth phenotypes of a gene deletion, of insertions, and of nonsense mutations indicate that the C31 protein is strictly required for cell growth and that most of the acidic domain is essential for its function. Random mutagenesis failed to yield temperature-sensitive mutants, but a slowly growing mutant was constructed by partial suppression of a UAA nonsense allele of RPC31. Its reduced rate of tRNA synthesis in vivo relative to 5.8S rRNA supports the hypothesis that the C31 protein is a functional subunit of RNA polymerase C.
Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury.

CONTEXT The omega-3 (n-3) fatty acids docosahexaenoic acid and eicosapentaenoic acid, along with γ-linolenic acid and antioxidants, may modulate systemic inflammatory response and improve oxygenation and outcomes in patients with acute lung injury. OBJECTIVE To determine if dietary supplementation of these substances to patients with acute lung injury would increase ventilator-free days to study day 28. DESIGN, SETTING, AND PARTICIPANTS The OMEGA study, a randomized, double-blind, placebo-controlled, multicenter trial conducted from January 2, 2008, through February 21, 2009. Participants were 272 adults within 48 hours of developing acute lung injury requiring mechanical ventilation whose physicians intended to start enteral nutrition at 44 hospitals in the National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. All participants had complete follow-up. INTERVENTIONS Twice-daily enteral supplementation of n-3 fatty acids, γ-linolenic acid, and antioxidants compared with an isocaloric control. Enteral nutrition, directed by a protocol, was delivered separately from the study supplement. MAIN OUTCOME MEASURE Ventilator-free days to study day 28. RESULTS The study was stopped early for futility after 143 and 129 patients were enrolled in the n-3 and control groups. Despite an 8-fold increase in plasma eicosapentaenoic acid levels, patients receiving the n-3 supplement had fewer ventilator-free days (14.0 vs 17.2; P = .02) (difference, -3.2 [95% CI, -5.8 to -0.7]) and intensive care unit-free days (14.0 vs 16.7; P = .04). Patients in the n-3 group also had fewer nonpulmonary organ failure-free days (12.3 vs 15.5; P = .02). Sixty-day hospital mortality was 26.6% in the n-3 group vs 16.3% in the control group (P = .054), and adjusted 60-day mortality was 25.1% and 17.6% in the n-3 and control groups, respectively (P = .11). Use of the n-3 supplement resulted in more days with diarrhea (29% vs 21%; P = .001). CONCLUSIONS Twice-daily enteral supplementation of n-3 fatty acids, γ-linolenic acid, and antioxidants did not improve the primary end point of ventilator-free days or other clinical outcomes in patients with acute lung injury and may be harmful. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00609180.
Value of Acid Metabolic Products in Identification of Certain Corynebacteria

Acid metabolic products of 23 strains of human and animal pathogenic corynebacteria, representing eight different species, were determined by gas chromatography. The results showed that the species examined were metabolically heterogeneous and could be presumptively identified based on the acid products produced. Corynebacterium equi did not produce any acids; C. renale produced lactate; and C. pyogenes produced major amounts of lactate, variable amounts of acetate, and minor amounts of succinate and pyruvate. C. kutscheri produced propionate and lactate as major products and pyruvate and oxalacetate as minor products. C. diphtheriae and C. pseudotuberculosis produced major amounts of propionate, acetate, and formate. In addition, C. pseudotuberculosis produced major amounts of pyruvate and minor amounts of succinate, lactate, and oxalacetate, whereas C. diphtheriae strains produced minor but variable amounts of lactate, succinate, fumarate, pyruvate, and oxalacetate. C. bovis produced aicd products similar to those of C. pyogenes but was readily distinguishable from the latter by the lack of hemolysis on blood agar, colony morphology, catalase reaction, and biochemicals. C. suis characteristically produced major amounts of ethanol, acetate, and formate and minor amounts of lactate and succinate but no propionate.
The multilevel analysis of students' achievement in learning the Chinese language.

A three-level hierarchical or multilevel model is employed to examine the factors that influence students’ achievement in learning the Chinese language. The factors might be many or various, such as school factors, factors related to teachers, parents and peers. This study, however, only examines student level factors. The first level of the three-level multilevel model is the within-student level; the second level is betweenstudent level; and the third level is between- class level. The results show that different factors at different levels of the model have effects on the students’ achievement. Interaction effects are also observed between some variables and the achievement.
Small GTPases and the evolution of the eukaryotic cell.

The origin of eukaryotes is one of the major challenges of evolutionary cell biology. Other than the endosymbiotic origin of mitochondria and chloroplasts, the steps leading to eukaryotic endomembranes and endoskeleton are poorly understood. Ras-family small GTPases are key regulators of cytoskeleton dynamics, vesicular trafficking and nuclear function. They are specific for eukaryotes and their expansion probably traces the evolution of core eukaryote features. The phylogeny of small GTPases suggests that the first endomembranes to evolve during eukaryote evolution had secretory, and not phagocytic, function. Based on the reconstruction of putative roles for ancestral small GTPases, a hypothetical scenario on the origins of the first endomembranes, the nucleus, and phagocytosis is presented.
Impact of delay in clinical presentation on the diagnostic management and prognosis of patients with suspected pulmonary embolism.

RATIONALE The nonspecific clinical presentation of pulmonary embolism (PE) frequently leads to delay in its diagnosis. OBJECTIVES This study aimed to assess the impact of delay in presentation on the diagnostic management and clinical outcome of patients with suspected PE. METHODS In 4,044 consecutive patients with suspected PE, patients presenting more than 7 days from the onset of symptoms were contrasted with those presenting within 7 days as regards the safety of excluding PE on the basis of a clinical decision rule combined with D-dimer testing. Patients were followed for 3 months to assess the rates of recurrent venous thromboembolism and mortality. MEASUREMENTS AND MAIN RESULTS A delayed presentation (presentation >7 d) was present in 754 (18.6%) of the patients. The failure rate of an unlikely clinical probability and normal D-dimer test was 0.5% (95% confidence interval [CI], 0.01-2.7) for patients with and 0.5% (95% CI, 0.2-1.2) for those without diagnostic delay. D-dimer testing yielded a sensitivity of 99% (95% CI, 96-99%) and 98% (95% CI, 97-99%) in these groups, respectively. Patients with PE with diagnostic delay more frequently had centrally located PE (41% vs. 26%; P < 0.001). The cumulative rates of recurrent venous thromboembolism (4.6% vs. 2.7%; P = 0.14) and mortality (7.6% vs. 6.6%; P = 0.31) were not different for patients with and without delayed presentation. CONCLUSIONS PE can be safely excluded based on a clinical decision rule and D-dimer testing in patients with a delayed clinical presentation. A delayed presentation for patients who survived acute PE was associated with a more central PE location, although this did not affect the clinical outcome at 3 months.
Efectos de cambios en el uso de la tierra sobre ensambles de roedores en agroecosistemas pampeanos

El objetivo general de esta tesis fue analizar el efecto del uso de la tierra y de variables climaticas sobre las comunidades de roedores en un agroecosistema pampeano a distintas escalas temporales y espaciales. Para ello se realizaron muestreos estacionales de roedores durante 2006-2008 en los distintos ambientes presentes en el area de estudio y se analizaron datos de abundancia de roedores y de variables climaticas desde 1984 hasta 2008. Tambien se compararon las abundancias de roedores y caracteristicas de la vegetacion entre los periodos anterior y posterior a la expansion de la soja. Las fluctuaciones en las abundancias de roedores estuvieron relacionadas con la precipitacion, pero la tendencia a la disminucion observada en . Calomys laucha y Calomys musculinus fue mejor explicada por cambios en el uso de la tierra que por las variables climaticas. Excepto las granjas avicolas, que serian las principales responsables del mantenimiento de M. musculus en el area, el resto de los ambientes estudiados presentaron composicion similar de especies, aunque con abundancia variable. Los terraplenes de via, los arroyos y los bordes de pastizal y cultivo, jugarian un papel importante en el mantenimiento de O. flavescens y O. rufus, y en gran medida de A. azarae, aunque esta ultima tambien hace uso de los campos de cultivo. A una escala de paisaje, los campos de cultivo son el ambiente que mas aporta a la abundancia total de roedores ya que si bien no presentan una alta densidad, ocupan mas del 88% del area total.
Pervasive data sharing as an enabler for mobile citizen sensing systems

Today, users can use their personal devices for a wide range of applications and services, such as controlling other devices, monitoring human physiological signals, and accessing information while on the move. Due to the communication and sensing capability of personal and wearable devices, their pervasive deployment and use may lead to an improvement of social and personal welfare by exploiting novel mobile citizen sensing systems. However, the pervasiveness of such large-scale sensing systems is only possible if devices are able to share sensing data independent of the available communication infrastructure, their location, and applications making use of the collected data. This article describes a set of paradigms that should be considered to build pervasive data sharing systems, and proposes a node architecture to implement them.
RF transistor macromodeling with substrate effect in power amplifier design

In this paper, a class AB power amplifier is designed in the 2.45 GHz frequency band using a standard 0.35/spl mu/m CMOS digital process. The transistor RF modeling including the substrate effect is emphasized in this design. The power amplifier delivers 24dBm of output power with an efficiency of 34.5%, PAE of 30.5% and a power gain of 9.5dB under 3.3V supply. Effect of pads and bondwires are taken into consideration during the design process. The coil used for tuning purposes is a standard above IC MEMS coil in order to increase the efficiency of the PA. Finally, a comparison between the performance of the PA with and without the external subcircuit is given.
Caveolin‐1 secreting LNCaP cells induce tumor growth of caveolin‐1 negative LNCaP cells in vivo

Caveolin‐1 (Cav‐1) was originally identified as a structural protein of caveolae, which is a plasma membrane domain that regulates a variety of signaling pathways involved in cell growth and migration. Here, we show that expression of Cav‐1 in the Cav‐1‐deficient human prostate cancer cell line LNCaP both stimulates cell proliferation and promotes tumor growth in nude mice. Unexpectedly, Cav‐1 expressing LNCaP (LNCaPCav‐1) cells injected into one side of a nude mouse promoted tumor growth of Cav‐1 negative LNCaP cells injected on the contralateral side of the same animal. The LNCaP tumors were positive for Cav‐1, however, this signal was not caused by migrated LNCaPCav‐1 cells, but we show that this Cav‐1 was secreted by the LNCaPCav‐1 tumors. We demonstrate that conditioned media from LNCaPCav‐1 cells contained Cav‐1 that was associated with a lipoprotein particle ranging in size from 15 to 30 nm and a density similar to high density lipoprotein particle. These results suggest that LNCaPCav‐1 cells secreting Cav‐1 particle produce an endocrine factor that stimulates tumor growth. © 2007 Wiley‐Liss, Inc.
Big data and data science: what should we teach?

The era of big data has arrived. Big data bring us the data‐driven paradigm and enlighten us to challenge new classes of problems we were not able to solve in the past. We are beginning to see the impacts of big data in every aspect of our lives and society. We need a science that can address these big data problems. Data science is a new emerging discipline that was termed to address challenges that we are facing and going to face in the big data era. Thus, education in data science is the key to success, and we need concrete strategies and approaches to better educate future data scientists. In this paper, we discuss general concepts on big data, data science, and data scientists and show the results of an extensive survey on current data science education in United States. Finally, we propose various approaches that data science education should aim to accomplish.
for Humanoid Kidsize League of RoboCup 2015

We performed match at RoboCup2014 with our own robot, KUbot. Throught the competition we found our robot’s strength and weakness. In RoboCup2015 we have new challenges as the rules changes. The ball’s size and color are changed and (cid:12)eld is covered with arti(cid:12)-cial grass. To deal with it and perform well in RoboCup2015, we made two new versions of our robot; KUbot2 and KUbot-teen. We also implemented many things like new walking pattern generator with ZMP and new object detection system with SURF algorithm in them. This paper brie(cid:13)y describe our preparation and research for RoboCup2015.
Omni-Directional Stereo

Omnidirectional views of an indoor environment at different locations are integrated into a global map. A single camera swiveling about the vertical axis takes consecutive images and arranges them into a panoramic representation, which provides rich information around the observation point: a precise omnidirectional view of the environment and coarse ranges to objects in it. Using the coarse map, the system autonomously plans consecutive observations at the intersections of lines connecting object points, where the directions of the imaging are estimated easily and precisely. From two panoramic views at the two planned locations, a modified binocular stereo method yields a more precise, but with direction-dependent uncertainties, local map. New observation points are selected to decrease the uncertainty, and another local map is yielded, which is then integrated into a more reliable global representation of the world with the adjacent local maps. >
FI-Based Local Group Key Generation/Distribution for Mobile Multicast in a Hierarchical Mobile IPv6 Network

In order to securely transmit multicast data packets in a mobile environment where frequent join/leave events are a characteristic of the environment, there is a need for a new secure and efficient group key management solution. We propose a secure group key generation/distribution solution providing scalability and reliability. Using this solution, when a mobile node, which is in a multicast session, enters a new domain, the agent of the domain joins the multicast session and coordinates its data packets with the mobile node. The agent encrypts and transmits subsequent data packets to the mobile node, using a local one-time pad key. This key is generated with FI sequences, enabling the mobile node to regenerate the same data packet, based on the information sent by the agent. Our performance analysis demonstrates that the proposed solution can significantly reduce the number of key generations and distributions, when it is applied to the hierarchical mobile IPv6 network.
A rapid, quantitative fluorescence assay for cell damage by cytotoxic antibodies.

Our laboratory recently (1) described a fluorochromatic assay for cell damage by cytotoxic alloantibody, which was based on retention of fluorescein by intact cells after its hydrolysis from fluorescein diacetate esters (FDA) (2). Although the method gave reproducible results in our hands, it was slow and always subject to error, since traces of complement used in the reaction were capable of hydrolyzing FDA, thus yielding erroneously high values of cell viability. This was not satisfactory and accordingly we sought another approach to differential fluorescent staining of cells, which would still allow machine-reading of the assays. Rather than looking for other compounds that were enzymatically changed from non-fluorescent to fluorescent, we chose to screen a number of fluorescent probes (3), compounds whose fluorescence is enhanced when bound to protein or nucleic acids. Such compounds were initially screened by observing fresh and heat-damaged lymphocytes, bathed in solutions of various probes, with the fluorescence microscope.
Subtle alterations of cardiac performance in children with growth hormone deficiency: results of a two-year prospective, case-control study.

BACKGROUND GH-deficient (GHD) children have reduced left ventricular (LV) mass, but impairment of cardiac function has never been documented. AIM The aim of the study was to evaluate effects of GHD and GH therapy on cardiac function using load-dependent and load-independent indices of myocardial contractility. PATIENTS AND METHODS Echocardiography was performed in 24 GHD children at baseline and 1 and 2 yr after GH therapy and in 24 controls. RESULTS Compared with controls, GHD children at baseline had lower LV mass (LV mass/BSA 50.6 +/- 1.8 vs. 60.5 +/- 2.4 g/m(2); P < 0.002, and LV mass/H(2.7) 28.7 +/- 1.2 vs. 33.6 +/- 1.3 g/m(2.7); P < 0.009). Global systolic function was normal, with only a trend toward slight impairment of the fractional shortening (34.9 +/- 1.5 vs. 37.6 +/- 1.1%). However, subtle LV dysfunction was revealed by load-dependent and load-independent indices of myocardial contractility. In fact, GHD patients compared with controls showed lower rate-corrected mean velocity of circumferential fiber shortening (1.0 +/- 0.03 vs. 1.18 +/- 0.03 circ/sec; P = 0.0001) and stress shortening index (0.10 +/- 0.02 vs. 0.18 +/- 0.02; P < 0.007) and higher end-systolic stress (49.2 +/- 1.4 vs. 45.7 +/- 1.0 g/cm(2); P < 0.05). One year of GH treatment was associated with a significant improvement of cardiac size (LV mass/BSA 67.8 +/- 2.9 g/m(2); LV mass/H(2.7) 38.2 +/- 2.0 g/m(2.7); P < 0.0001 and P = 0.0003, respectively) and myocardial contractility (mean velocity of circumferential fiber shortening 1.2 +/- 0.04 circ/sec; P < 0.0002; stress shortening index 0.19 +/- 0.02; P < 0.003) and reduced afterload (end-systolic stress 43.9 +/- 1.4 g/cm(2); P < 0.03). CONCLUSIONS Our data indicate that GH deficiency is associated with abnormalities in morphology and function in not only adults but also children and further supports the beneficial effect of GH on the heart.
CT detection of facial canal dehiscence and semicircular canal fistula: comparison with surgical findings.

OBJECTIVE The purpose of this study was to determine the accuracy of high resolution CT (HRCT) in the detection of facial canal dehiscence and semicircular canal fistula, the preoperative evaluation of both of which is clinically very important for ear surgery. MATERIALS AND METHODS We retrospectively reviewed the HRCT findings in 61 patients who underwent mastoidectomy at Yamagata University between 1989 and 1993. The HRCT images were obtained in the axial and semicoronal planes using 1 mm slice thickness and 1 mm intersection gap. RESULTS In 46 (75%) of the 61 patients, the HRCT image-based assessment of the facial canal dehiscence coincided with the surgical findings. The data for the facial canal revealed sensitivity of 66% and specificity of 84%. For semicircular canal fistula, in 59 (97%) of the 61 patients, the HRCT image-based assessment and the surgical findings coincided. The image-based assessment in the remaining two patients, who both had massive cholesteatoma, was false-positive. CONCLUSION HRCT is useful in the diagnosis of facial canal dehiscence and labyrinthine fistula, but its limitations should also be recognized.