Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiparameter Intelligent Monitoring in Intensive Care II: A public-access intensive care unit database*

Objective:We sought to develop an intensive care unit research database applying automated techniques to aggregate high-resolution diagnostic and therapeutic data from a large, diverse population of adult intensive care unit patients. This freely available database is intended to support epidemiologic research in critical care medicine and serve as a resource to evaluate new clinical decision support and monitoring algorithms. Design:Data collection and retrospective analysis. Setting:All adult intensive care units (medical intensive care unit, surgical intensive care unit, cardiac care unit, cardiac surgery recovery unit) at a tertiary care hospital. Patients:Adult patients admitted to intensive care units between 2001 and 2007. Interventions:None. Measurements and Main Results:The Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC-II) database consists of 25,328 intensive care unit stays. The investigators collected detailed information about intensive care unit patient stays, including laboratory data, therapeutic intervention profiles such as vasoactive medication drip rates and ventilator settings, nursing progress notes, discharge summaries, radiology reports, provider order entry data, International Classification of Diseases, 9th Revision codes, and, for a subset of patients, high-resolution vital sign trends and waveforms. Data were automatically deidentified to comply with Health Insurance Portability and Accountability Act standards and integrated with relational database software to create electronic intensive care unit records for each patient stay. The data were made freely available in February 2010 through the Internet along with a detailed user's guide and an assortment of data processing tools. The overall hospital mortality rate was 11.7%, which varied by critical care unit. The median intensive care unit length of stay was 2.2 days (interquartile range, 1.1–4.4 days). According to the primary International Classification of Diseases, 9th Revision codes, the following disease categories each comprised at least 5% of the case records: diseases of the circulatory system (39.1%); trauma (10.2%); diseases of the digestive system (9.7%); pulmonary diseases (9.0%); infectious diseases (7.0%); and neoplasms (6.8%). Conclusions:MIMIC-II documents a diverse and very large population of intensive care unit patient stays and contains comprehensive and detailed clinical data, including physiological waveforms and minute-by-minute trends for a subset of records. It establishes a new public-access resource for critical care research, supporting a diverse range of analytic studies spanning epidemiology, clinical decision-rule development, and electronic tool development.
"we Need to Talk!" - Project Teams Dealing with low connectivity

The continuous technological development and the consistent reliance on ICT, has raised the expectations towards ubiquitous connectivity to an extent that technical failures or social disconnects are a serious threat for project teams and their performance, especially when team members are scattered around the world. We analyse hypo-connectivity, the state in which users face too few connectivity to work efficiently, and focus on its impact in project teams. By applying a mixed method approach in the context of an international consulting company, we investigate the two-sided phenomenon of hypoconnectivity and aim to identify the consequences of hypo-connectivity on communication effectiveness and efficiency, as well as the role of connectivity norms in this relationship. Our results show that hypo-connectivity has a negative influence on communication effectiveness and efficiency, which consequently leads to decreased performance, increased frustration and conflicts. However, the establishment of connectivity norms in project teams can ease the effects of hypo-connectivity, sustain the communication flow and balance the negative impact. We conclude that people actually “need to talk” about the dos and don’ts that sustain their communication flow and develop connectivity norms that could help the team circumvent the negative effects of hypo-connectivity.
Le partage des connaissances en développement international : influence des processus relationnels sur les résultats et incidences sur le renforcement des capacités

Canada spends millions in international aid each year. The Canadian Minister of Foreign Affairs, Trade and Development estimated the amount of international aid at more than 5.48 billion in 2013. In all projects, human resources are involved to build the capacity of local organizations in developing countries. These technical cooperation initiatives require assigned staff to accomplish a number of tasks, including knowledge-sharing. This thesis explores the underlying relational processes that characterize exchanges between stakeholders involved in knowledgesharing, namely international volunteer advisors and local teams who benefit from these initiatives. Results testify to the marked influence of interpersonal relations on knowledgesharing although trust alone will not suffice to fulfil sustainable development goals. Case analysis, primarily based on semi-structured interviews held in Haiti and Senegal, confirm the need to consider the dynamic absorptive capacity of stakeholders and the willingness of local management to partake in programs of knowledge-sharing.
A Transaction Level Assertion Verification Framework in SystemC: An Application Study

This paper presents a new transaction level assertion verification framework built on top of SystemC to support the integration of Assertion Based Verification in a Model Driven Design methodology. A key point of the proposed framework is that it enables decoupling the work of the design and verification teams. This is possible thanks to data introspection capabilities; the fact that the assertions are not embedded in the design model code; and the abstraction in the property specification. Thus, the two teams can work in parallel starting from the natural language specification, reducing the development time.
Cognitive-Behavioral Intervention Effects on Adolescents’ Anxiety and Pain Following Spinal Fusion Surgery

BackgroundCognitive-behavioral interventions, typically effective in reducing anxiety and pain, have not been applied to adolescents undergoing major orthopaedic surgery. ObjectivesTo determine the effectiveness of three cognitive-behavioral interventions for reducing adolescents’ postoperative anxiety and pain following spinal fusion surgery for scoliosis, and whether effectiveness depended on preoperative anxiety and age. MethodsA randomized controlled trial with four groups receiving a videotape intervention (information only, coping only, information plus coping, or control) used a convenience sample of 109 adolescents (88 female, 93 White), 11–18 years of age (M = 14). Speilberger’s (1983) State Anxiety scale assessed anxiety preoperatively and postoperatively on Day 2. A visual analogue scale assessed pain postoperatively on Days 2 and 4. ResultsInformation plus coping was most effective for reducing postoperative anxiety in adolescents with high preoperative anxiety. Coping instruction led to less postoperative anxiety and pain for adolescents ages 13 and younger. The control group reported the highest levels of pain on Day 4. ConclusionsCognitive-behavioral interventions designed to prepare adolescents for surgery should be tailored to individual factors and developmental needs, especially the adolescents’ preoperative anxiety level and age.
Canadian Parents for French: How a grassroots organization has contributed to the advancement of Canada's official languages policy

This article describes the efforts undertaken by a grassroots, non-profit association established to promote French-second-language learning in Canada, and how those efforts have contributed to the advancement of Canada’s official languages policy. After identifying the historical context in which the immersion approach to second language instruction was developed, we use a historical institutionalism theory with an archival research method to examine texts produced by Canadian Parents for French over the past 38 years to see how the organization has contributed to the growth of English-French bilingualism within Canada. We then note the continuing challenges to universal access to French immersion programs which the association has identified. This article demonstrates that stakeholders can play an important role in the successful implementation of a policy and offers examples that may be relevant for international audiences seeking to promote language learning.
Restructuring Transnational Mineral Agreements

Within our own generation no less than 70 countries have attained political independence and joined the international community of nation states. Third World countries now command a preponderant majority in the United Nations and other world bodies, yet it is trite knowledge that the attainment of political independence and the proliferation of nation states in the Third World have had little impact on the world economic power structure. Access to the corridors of the United Nations and other international bodies has not necessarily assured effective participation in the shaping and restructuring of the world economic system. After the first flush of exhilaration over political independence, developing countries have now grasped the sobering fact that sovereignty is not synonymous with economic self-sufficiency or development and that the rich industrialized countries still substantially control the production and distribution of the world’s resources. An analysis of European direct investment in Africa shows that by the end of 1967 the former metropolitan powers still dominated investments in their former colonies. (The percentage of the total foreign investments in these African countries held by the former imperial powers is illustrated in table 1.)
Crime Toolkits: The Productisation of Cybercrime

The productisation of crime toolkits is happening at an ever-increasing rate. Previous attacks that required in-depth knowledge of computer systems can now be purchased online. Large scale attacks previously requiring months to set-up a botnet can now be scheduled for a small fee. Criminals are leveraging this opportunity of commercialization, by compromising web applications and user's browser, to gain advantages such as using the computer's resources for launching further attacks, or stealing data such as identifying information.Crime toolkits are being developed to attack an increasing number of applications and can now be deployed by attackers with little technical knowledge. This paper surveys the current trends in crime toolkits, with a case study on the Zeus botnet. We profile the types of exploits that malicious writers prefer, with a view to predicting future attack trends. We find that the scope for damage is increasing, particularly as specialisation and scale increase in cybercrime.
Receptor-Determined Susceptibility of Preimplantation Embryos to Pseudorabies Virus and Porcine Reproductive and Respiratory Syndrome Virus

Abstract In the present study, the in vitro interaction of embryos with pseudorabies virus (PRV) and porcine reproductive and respiratory syndrome virus (PRRSV) was investigated by viral antigen detection and by evaluating the expression of virus receptors, namely, poliovirus receptor-related 1 (PVRL1; formerly known as nectin 1) for PRV and sialoadhesin for PRRSV. Embryonic cells of zona pellucida intact embryos incubated with PRV remained negative for viral antigens. Also, no antigen-positive cells could be detected after PRV incubation of protease-treated embryos, since the protease disrupted the expression of PRVL1. However, starting from the five-cell-stage onwards, viral antigen-positive cells were detected after subzonal microinjection of PRV. At this stage, the first foci of PVRL1, also a known cell adhesion molecule, were expressed. At the expanded blastocyst stage, a lining pattern of PVRL1 in the apicolateral border of trophectoderm cells was present, whereas the expression in the inner cell mass was low. Furthermore, PVRL1-specific monoclonal antibody CK41 significantly blocked PRV infection of trophectoderm cells of hatched blastocysts, while the infection of the inner cell mass was only partly inhibited. Viral antigen-positive cells were never detected after PRRSV exposure of preimplantation embryos up to the hatched blastocyst stage. Also, expression of sialoadhesin in these embryonic stages was not detected. We conclude that the use of protease to investigate the virus embryo interaction can lead to misinterpretation of results. Results also show that blastomeres of five-cell embryos up to the hatched blastocysts can become infected with PRV, but there is no risk of a PRRSV infection.
Patch auditing in infrastructure as a service clouds

A basic requirement of a secure computer system is that it be up to date with regard to software security patches. Unfortunately, Infrastructure as a Service (IaaS) clouds make this difficult. They leverage virtualization, which provides functionality that causes traditional security patch update systems to fail. In addition, the diversity of operating systems and the distributed nature of administration in the cloud compound the problem of identifying unpatched machines. In this work, we propose P2, a hypervisor-based patch audit solution. P2 audits VMs and detects the execution of unpatched binary and non-binary files in an accurate, continuous and OSagnostic manner. Two key innovations make P2 possible. First, P2 uses efficient information flow tracking to identify the use of unpatched non-binary files in a vulnerable way.We performed a patch survey and discover that 64% of files modified by security updates do not contain binary code, making the audit of non-binary files crucial. Second, P2 implements a novel algorithm that identifies binaries in mid-execution to allow handling of VMs resumed from a checkpoint or migrated into the cloud. We have implemented a prototype of P2 and and our experiments show that it accurately reports the execution of unpatched code while imposing performance overhead of 4%.
The salivary glands of the vector mosquito, Aedes aegypti, express a novel member of the amylase gene family

Several cDNA clones with similarity to α‐amylases have been characterized from a library made from adult female salivary gland RNA isolated from the vector mosquito, Aedes aegypti. The corresponding gene, designated Amylase I (Amy I), is expressed specifically in the proximal‐lateral lobes of the adult female salivary gland, a pattern overlapping that of another gene, Mal I, involved in carbohydrate metabolism. The deduced amino acid sequence of Amy I indicates that this gene encodes a protein, approximate Mr= 81,500, that appears to be a novel member of the amylase gene family. The mosquito protein contains a putative signal peptide for secretion and several consensus sites for asparagine‐linked glycosylation. The Amy I protein shows significant similarity to invertebrate and vertebrate amylases including the conservation of four reactive and substrate binding sites. However, the amino‐terminal region of the Amy‐I protein is unique to the mosquito. Similarity with the Drosophila melanogaster protein is evident only after the first 260 amino acids in the mosquito sequence. The identification of this gene and its expression pattern adds to the observed relationship between spatial‐specific gene expression in the female salivary glands and the specific feeding mode of the adult mosquito.
Mda-9/Syntenin Is Expressed in Uveal Melanoma and Correlates with Metastatic Progression

Uveal melanoma is an aggressive cancer that metastasizes to the liver in about half of the patients, with a high lethality rate. Identification of patients at high risk of metastases may provide indication for a frequent follow-up for early detection of metastases and treatment. The analysis of the gene expression profiles of primary human uveal melanomas showed high expression of SDCBP gene (encoding for syndecan-binding protein-1 or mda-9/syntenin), which appeared higher in patients with recurrence, whereas expression of syndecans was lower and unrelated to progression. Moreover, we found that high expression of SDCBP gene was related to metastatic progression in two additional independent datasets of uveal melanoma patients. More importantly, immunohistochemistry showed that high expression of mda-9/syntenin protein in primary tumors was significantly related to metastatic recurrence in our cohort of patients. Mda-9/syntenin expression was confirmed by RT-PCR, immunofluorescence and immunohistochemistry in cultured uveal melanoma cells or primary tumors. Interestingly, mda-9/syntenin showed both cytoplasmic and nuclear localization in cell lines and in a fraction of patients, suggesting its possible involvement in nuclear functions. A pseudo-metastatic model of uveal melanoma to the liver was developed in NOD/SCID/IL2Rγ null mice and the study of mda-9/syntenin expression in primary and metastatic lesions revealed higher mda-9/syntenin in metastases. The inhibition of SDCBP expression by siRNA impaired the ability of uveal melanoma cells to migrate in a wound–healing assay. Moreover, silencing of SDCBP in mda-9/syntenin-high uveal melanoma cells inhibited the hepatocyte growth factor (HGF)-triggered invasion of matrigel membranes and inhibited the activation of FAK, AKT and Src. Conversely syntenin overexpression in mda-9/syntenin-low uveal melanoma cells mediated opposite effects. These results suggest that mda-9/syntenin is involved in uveal melanoma progression and that it warrants further investigation as a candidate molecular marker of metastases and a potential therapeutic target.
The interplay among temperament, neuropsychological abilities, and global functioning in young hyperactive/inattentive children.

Cognition and emotion have been shown to interact and influence psychological functioning. However, to date these interactions have only been examined cross-sectionally among inattentive and/or hyperactive/impulsive children. This study investigated the moderating effects of neuropsychological functioning at age 3-4 years on the relation between negative emotionality at age 3-4 years and global functioning 1 year later, at age 4-5 years. Hyperactive/inattentive (H/I; n = 114) preschoolers entered the study (BL: baseline) and were seen again 1 year later (F1). Children's BL scores on a neuropsychological test (NEPSY) and their temperament as rated by parents (Child Behavior Questionnaire) and teachers (Temperament Assessment Battery for Children-Revised) were obtained, as were clinicians' ratings of their global functioning (Children's Global Assessment Scale) at F1. Hierarchical linear regression analyses revealed that BL temperament variables accounted for significant variance in F1 Global Functioning. Significant interactions indicated that higher Verbal Executive abilities were associated with better child functioning when parent-rated Effortful Control was high, but not when Effortful Control was low. Additionally, high levels of Nonverbal Executive skills were associated with higher child global functioning when both parent- and teacher-rated negative affect was low, but not when negative affect was high.
Stochastic modeling of IEEE 802.11p output process for efficient V2X large-scale interworking

Vehicle-to-anything (V2X) is a promising communication technology to support operability in large-scale vehicular networks. The future deployment of V2X necessitates interworking between different access technologies, i.e., Dedicated Short-Range Communications (DSRC) and Cellular networks. However to achieve an efficient V2X interworking, we need to resolve the multi-hop issue, mainly originating from the V2X hybrid architecture. To resolve this issue and consequently to analyze the interconnected system, characterizing the output process of IEEE 802.11p-based DSRC protocol is of a fundamental importance. This paper proposes stochastic Regenerative Model to provide a complete description of IEEE 802.11p output process. The accuracy of the model is verified through extensive simulations. As a case study, the proposed model is compared with the Poisson model in the performance evaluation of V2X interworking. Numerical and simulation results verify the ability of the Regenerative Model to capture the deviations of the actual output process of IEEE 802.11p under different traffic intensity as compared to the Poisson model.
Resolution Branch and Bound and an Application: The Maximum Weighted Stable Set Problem

We propose a new resolution algorithm, called resolution branch and bound (RBB), where a branch-and-bound scheme is empowered by exploiting the information contained in a family of closed subproblems, collected by a full resolution phase. In particular, we use this information to define a new branching rule that seems able to reduce the risk of incurring inappropriate branchings. We apply RBB and the proposed branching rule to the maximum weighted stable set problem, as its features allow us to speed up a time-consuming step in the full resolution phase. To compute upper bounds, we generalize to the weighted case the polynomial time procedure provided by Mannino and Sassano [Mannino, C. , A. Sassano. 1994. An exact algorithm for the maximum stable set problem. Computational Optim. Appl.3 243--258] for the unweighted case. Computational results validate the effectiveness of the provided branching rule and the good performance of RBB on many DIMACS benchmarks.
The discovery of three genetic races of the dwarf mistletoe Arceuthobium americanum (Viscaceae) provides insight into the evolution of parasitic angiosperms

A population genetic approach was used to explore the evolutionary biology of the parasitic angiosperm Arceuthobium americanum Nutt. ex Engelm. (Viscaceae). Arceuthobium americanum infects three principal hosts and has the most extensive geographical range of any North American dwarf mistletoe. Based on the lack of apparent morphological and phenological differences between populations of A. americanum, past researchers have found no evidence for recognizing infraspecific taxa. In this study, molecular analysis using amplified fragment length polymorphism (AFLP) analysis indicated that A. americanum is divided into three distinct genetic races, each associated with a different host taxon in regions of allopatry: (i) Pinus banksiana in western Canada; (ii) Pinus contorta var. murrayana in the Sierra Nevada and Cascade Mountain ranges in the western US; and (iii) Pinus contorta var. latifolia in the western US and Canada. These observations suggest that host identity, geographical isolation and environmental factors have contributed to race formation in A. americanum. The lack of fine‐scale patterning within each of the A. americanum races is attributed to random dispersal of seeds over long distances by animal vectors. Historical factors such as glaciations and founder events have also influenced structuring and genetic diversity in A. americanum populations. Given sufficient time, it is possible that these races will become reproductively isolated and undergo speciation.
Longitudinal Changes in BMD and Bone Geometry in a Population‐Based Study

We prospectively examined vBMD and structural bone parameters assessed by QCT among participants of the InCHIANTI study over a 6‐yr follow‐up. Periosteal apposition occurred both in men and women. Endocortical resorption causes bone loss in older women despite periosteal apposition.