Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationships between standard automated perimetry, HRT confocal scanning laser ophthalmoscopy, and GDx VCC scanning laser polarimetry.

PURPOSE This study was designed to determine and compare the relationships between visual function measured with standard automated perimetry (SAP) and structure, either as neuroretinal rim area measured with confocal scanning laser ophthalmoscopy (CSLO), or as retinal nerve fiber layer thickness determined by scanning laser polarimetry with variable corneal compensation (SLP-VCC). METHODS Forty-six healthy subjects and 76 glaucoma patients were examined with SAP, with CSLO by means of the commercially available Heidelberg Retina Tomograph I (HRT), and with SLP-VCC by means of the commercially available GDx VCC. The relationships between SAP, expressed either in the typically used decibel scale or as number of abnormal points in the total deviation probability plot, and CSLO and between SAP and SLP-VCC were described with linear and logarithmic regression analysis for global data and six individual sectors. The relationship between measurements with CSLO and SLP-VCC was fit with linear regression analysis. RESULTS The relationships between SAP and CSLO and between SAP and SLP-VCC appeared curvilinear for all sectors except the temporal one between SAP and SLP-VCC. For CSLO, a logarithmic fit was significantly better than a linear one for the global data and in the superotemporal and inferonasal sectors. For SLP-VCC, a curvilinear fit was better for the global data and in the superotemporal, superonasal, and inferonasal sectors. CSLO data correlated linearly with SLP-VCC data in all sectors, except temporally. CONCLUSIONS CSLO and SLP-VCC showed a very similar curvilinear relationship with SAP. The observed curvilinear relationships confirm earlier reports that these imaging devices appear to detect glaucomatous loss earlier than SAP.
MSBGA: A Multi-Document Summarization System Based on Genetic Algorithm

The multi-document summarizer using genetic algorithm-based sentence extraction (MSBGA) regards summarization process as an optimization problem where the optimal summary is chosen among a set of summaries formed by the conjunction of the original articles sentences. To solve the NP hard optimization problem, MSBGA adopts genetic algorithm, which can choose the optimal summary on global aspect. The evaluation function employs four features according to the criteria of a good summary: satisfied length, high coverage, high informativeness and low redundancy. To improve the accuracy of term frequency, MSBGA employs a novel method TFS, which takes word sense into account while calculating term frequency. The experiments on DUC04 data show that our strategy is effective and the ROUGE-1 score is only 0.55% lower than the best participant in DUC04
Insulin resistance and obesity‐related factors in Prader–Willi syndrome: Comparison with obese subjects

Prader–Willi syndrome (PWS), the most common genetic cause of marked obesity in humans, is usually due to a de novo paternally derived chromosome 15q11–q13 deletion or maternal disomy 15 [(uniparental disomy (UPD)]. Obesity is due to energy imbalance, but few studies have examined fat patterning and obesity‐related factors in subjects with PWS (deletions and UPD) compared with subjects with simple obesity. We examined for differences in fatness patterning and lipid, leptin, and glucose and insulin levels in subjects with simple obesity and PWS and adjusted for gender, age, and body mass index (BMI). Fasting peripheral blood samples and cross‐sectional magnetic resonance image scans at the level of the umbilicus were obtained in 55 subjects ranging in age from 10.4 to 49 years: 20 PWS deletion, 17 PWS UPD, and 18 obese controls. Subcutaneous fat area (SFA) and intra‐abdominal visceral fat area (VFA) were calculated. No significant difference was seen between the PWS deletion subjects or PWS UPD subjects for fatness measurements or leptin levels. Twenty‐three of 37 PWS subjects met the criteria for obesity (BMI > 95th percentile). No significant differences were observed for SFA and VFA between the PWS subjects judged to be obese and control subjects with simple obesity. There was an overall trend for decreased VFA in the PWS subjects but not significantly different. VFA was significantly positively correlated with both fasting insulin and total cholesterol in PWS deletion subjects but not in PWS UPD subjects or obese controls. Fasting insulin level was significantly lower in the obese PWS subjects compared with subjects with simple obesity, and insulin sensitivity (QUICKI) was significantly higher in PWS subjects with obesity. Homeostasis model assessment (HOMA) and QUICKI values were correlated and in opposite directions with triglycerides in the obese PWS subjects but not in the obese controls. Subjects in each group were stratified according to published criteria on the basis of their level of visceral fat (e.g. ≥ 130 cm2) to assess the influence of VFA on metabolic abnormalities. In the obese PWS subjects, the fasting triglyceride, glucose, and insulin levels, and HOMA value were significantly elevated, while the QUICKI value was significantly lower in those with VFA ≥ 130 cm2. Such significant differences were not seen in the obese control group. Our results indicate that VFA may be regulated differently in PWS subjects compared to individuals with simple obesity. Insulin resistance is lower in PWS subjects and insulin sensitivity is higher compared with obese controls. PWS subjects with increased VFA may be at a higher risk of obesity‐related complications compared to PWS subjects without increased VFA.
Is Geo-Indistinguishability What You Are Looking for?

Since its proposal in 2013, geo-indistinguishability has been consolidated as a formal notion of location privacy, generating a rich body of literature building on this idea. A problem with most of these follow-up works is that they blindly rely on geo-indistinguishability to provide location privacy, ignoring the numerical interpretation of this privacy guarantee. In this paper, we provide an alternative formulation of geo-indistinguishability as an adversary error, and use it to show that the privacy vs. utility trade-off that can be obtained is not as appealing as implied by the literature. We also show that although geo-indistinguishability guarantees a lower bound on the adversary's error, this comes at the cost of achieving poorer performance than other noise generation mechanisms in terms of average error, and enabling the possibility of exposing obfuscated locations that are useless from the quality of service point of view.
Pose Based Person Identification Using Kinect

The importance of automatic person identification using non-intrusive biometric modality has created enormous interest in computer vision society over the last few years. For this, gait based person recognition is receiving much more attention in different applications like visual surveillance, security control, people counting. In this paper, we have presented a gait based person identification system using 3D human pose modeling for any arbitrary walking pattern in any unrestricted indoor environment, using Microsoft Kinect sensor. Instead of estimating gait cycle, we have modeled the gait pattern with a spatiotemporal set of key poses and sub-poses which occur periodically in different gait cycles. The robustness of the solution is increased by outlier detection to handle noisy skeleton data obtained from Kinect. The performance of the proposed system is also assessed with rotating Kinect setup to increase the field of view of single Kinect. We have done the average and worst case performance evaluation of the system with respect to the existing Kinect based approaches. It needs to be mentioned that our proposed person identification system is able to achieve a frame level F-score of more than 90% for 20 subjects with fixed Kinect setup.
Adaptive Unknown Input Estimation by Sliding Modes and Differential Neural Network Observer

In this paper, a differential neural network (DNN) implemented as a robust observer estimates the dynamics of perturbed uncertain nonlinear systems affected by exogenous unknown inputs. In the first stage, the identification error converges into a neighborhood around the origin. Then, the second-order sliding mode supertwisting algorithm implemented as a robust exact differentiator reconstructed the unknown inputs. The approach proposed in this paper can be applied in the case of full access to the state vector (identification problem) and in the case of partial access to the state vector (estimation problem). In the second case, the nonlinear system under study must have well-defined full relative degree with respect to the unknown input. Numerical examples showed the effectiveness of the proposed algorithm. The first example tested the DNN working as an identifier into a mathematical model describing the dynamics of a spatial minisatellite. The second example (with a DNN implemented as an observer) tested the methodology of this paper over a single link flexible robot manipulator represented in a canonical (Brunovsky) form. In both examples, the mathematical models served as data generators in the testing of the neural networks. Even when not exact mathematical description of both models was used in the input estimation, the accuracy obtained with the DNN is comparable with the case of applying a high-order differentiator with complete knowledge of the plant.
Psychosocial Factors in Patients With Noncardiac Chest Pain

Objective This study sought to explore some psychosocial factors that distinguished individuals with noncardiac chest pain (NCCP) from those without NCCP, and whether these psychosocial factors were associated with anxiety and depression that are co-morbid factors of NCCP. Methods A matched case-control design was adopted to compare differences in psychosocial factors among a target group of patients with NCCP (N = 70), a pain control group of patients with rheumatism (N = 70), and a community control group of healthy individuals (N = 70). Results Compared with subjects from the two control groups, NCCP patients tended to monitor more, use more problem-focused coping, display a coping pattern with a poorer strategy-situation fit, and receive less emotional support in times of stress. Moreover, monitoring perceptual style and problem-focused coping were associated with higher levels of anxiety and depression. Coping pattern with a strategy-situation fit and emotional support were related to lower levels of anxiety and depression. Conclusions The present new findings suggest that monitoring perceptual style and inflexible coping style are risk factors that enhance one’s vulnerability to NCCP. Emotional support may be a resource factor that reduces one’s susceptibility to NCCP.
Positive experiences associated with acquired hearing loss, Ménière's disease, and tinnitus: A review

Abstract Objective: It is common to study and understand how various illness and disorders result in negative consequences. However, positive experiences have been reported in a range of disabling conditions including multiple sclerosis, heart disease, physical and sensory disabilities. This paper presents a literature review of studies that have explored positive experiences associated with acquired hearing loss, Ménière's disease, and tinnitus. Design: A review of the peer reviewed scientific literature. Study sample: A comprehensive search strategy identified 15 articles after applying inclusion criteria. Results: A range of positive experiences have been reported by patients with hearing and balance disorders and by their significant others. Associations between demographic variables (e.g. age, gender), audiological variables (e.g. severity of the condition, duration) and the reported positive experiences are low. In Ménière's disease, self-reported positive experiences can predict the impact of the condition. However, this phenomenon has not yet been demonstrated in relation to hearing loss and tinnitus. Conclusions: Positive experiences associated with audio-vestibular disorders have been demonstrated. Further research is needed on the long-term benefits of the encouragement of such experiences and positive attitudes in persons with hearing loss, tinnitus, and imbalance.
Digital contrast enhancement of 18Fluorine-fluorodeoxyglucose positron emission tomography images in hepatocellular carcinoma

Purpose: The role of 18 fluorodeoxyglucose positron emission tomography (PET) is limited for detection of primary hepatocellular carcinoma (HCC) due to low contrast to the tumor, and normal hepatocytes (background). The aim of the present study was to improve the contrast between the tumor and background by standardizing the input parameters of a digital contrast enhancement technique. Materials and Methods: A transverse slice of PET image was adjusted for the best possible contrast, and saved in JPEG 2000 format. We processed this image with a contrast enhancement technique using 847 possible combinations of input parameters (threshold "m" and slope "e"). The input parameters which resulted in an image having a high value of 2 nd order entropy, and edge content, and low value of absolute mean brightness error, and saturation evaluation metrics, were considered as standardized input parameters. The same process was repeated for total nine PET-computed tomography studies, thus analyzing 7623 images. Results: The selected digital contrast enhancement technique increased the contrast between the HCC tumor and background. In seven out of nine images, the standardized input parameters "m" had values between 150 and 160, and for other two images values were 138 and 175, respectively. The value of slope "e" was 4 in 4 images, 3 in 3 images and 1 in 2 images. It was found that it is important to optimize the input parameters for the best possible contrast for each image; a particular value was not sufficient for all the HCC images. Conclusion: The use of above digital contrast enhancement technique improves the tumor to background ratio in PET images of HCC and appears to be useful. Further clinical validation of this finding is warranted.
Predictive value of POSSUM score in surgery of acute abdomen in cirrhotic patients

Abstract Introduction: As liver cirrhosis has an increasing incidence in the general population and the life expectancy for these patients has increased, surgery procedures practiced for acute abdomen in such category of patients are more frequent. Aim: To evaluate the predictive value of POSSUM score in cirrhotic patients undergoing abdominal surgery in emergency cases. Material and method: A prospective study based on 115 consecutive patients with liver cirrhosis hospitalized and operated in the first 24 hours from admission for acute abdomen. The patients’ stratification was done by using Child Pugh score for liver cirrhosis. POSSUM score was calculated for each patient and postoperative outcomes were compared with prediction based on this score. Statistical data analysis was made by using the chi-square test and a p value of less than 0,05 was considered to be statistically significant. Results: There were 33 patients in stage Child A of cirrhosis, 54 in stage Child B and 28 in stage Child C. For Child A group, the POSSUM score had a satisfactory prediction in terms of morbidity and mortality. In advanced stages of liver cirrhosis, Child B and C, mortality had high rate and the observed outcomes were outside the area of POSSUM score prediction. Conclusions: POSSUM score offers a satisfactory prediction for morbidity and mortality in emergency abdominal surgery for patients in compensated stages of liver cirrhosis. In advanced stages of cirrhosis high levels of mortality cannot be predicted by using POSSUM score.
Using the Phenoscape Knowledgebase to relate genetic perturbations to phenotypic evolution

The abundance of phenotypic diversity among species can enrich our knowledge of development and genetics beyond the limits of variation that can be observed in model organisms. The Phenoscape Knowledgebase (KB) is designed to enable exploration and discovery of phenotypic variation among species. Because phenotypes in the KB are annotated using standard ontologies, evolutionary phenotypes can be compared with phenotypes from genetic perturbations in model organisms. To illustrate the power of this approach, we review the use of the KB to find taxa showing evolutionary variation similar to that of a query gene. Matches are made between the full set of phenotypes described for a gene and an evolutionary profile, the latter of which is defined as the set of phenotypes that are variable among the daughters of any node on the taxonomic tree. Phenoscape’s semantic similarity interface allows the user to assess the statistical significance of each match and flags matches that may only result from differences in annotation coverage between genetic and evolutionary studies. Tools such as this will help meet the challenge of relating the growing volume of genetic knowledge in model organisms to the diversity of phenotypes in nature. The Phenoscape KB is available at http://kb.phenoscape. org.
A Comparison of Backward and Forward Spatial Spans

The standard Corsi blocks task is frequently used to measure the capacity of visuospatial working memory, but the implications of the use of both forward and backward recall are still unclear. In the present study, we showed that the backward Corsi task is particularly powerful in discriminating between low- and high-spatial-ability individuals and involves different processes from those involved in the forward task. From a sample of 425 participants we selected one group of 20 high-spatial-ability participants and one of 20 low-spatial-ability participants. The results demonstrated that a backward spatial span offers specific information not available from a forward spatial span, and that there was no facilitation due to a descending format. In particular, in the low-spatial-ability group, performance was generally poorer, but backward Corsi recall was lower than forward recall, and participants did not show any advantage following the descending presentation format—which in some contexts is considered to reduce proactive interference. We conclude that the backward Corsi task has specific value and that the assumption of fully parallel verbal and visuospatial working-memory systems can lead to a variety of misunderstandings.
Chemotherapy of glioblastoma by targeted liposomal platinum compounds with focused ultrasound

Giloblastoma multiforme (GBM) is the most aggressive brain neoplasm, and patients have a poor prognosis after radiation and chemotherapy. The chemotherapy protocols still marginally improve the anti-tumor effect of patients with glioblastoma because the therapeutic dosage of many drugs is impeded by the blood-brain barrier (BBB). The use of liposomal drugs to GBM treatment might benefit from a more crossing of the BBB due to the lipid nature achieving higher doses of drug at the tumor sites. Human GBM-bearing mice were injected intravenously with cisplatin encapsulated in atherosclerotic plaque-specific peptide-1 (AP-1)-conjugated liposomes or unconjugated liposome. Moreover, the administration of AP-1 liposomal cisplatin (lipoplatin) followed by focused ultrasound (FUS)-induced BBB disruption. Tumor progression was monitored by biophotonic imaging. The preliminary data demonstrated that the GBM chemotherapy with AP-1 lipoplatin followed by pulsed FUS showed a modest improvement of tumor growth in the brain compared to the group treated with lipoplatin alone. Further investigations are needed to use this new targeted lipoplatin in treatment of malignancies.
Efficacy studies of influenza vaccines: effect of end points used and characteristics of vaccine failures.

BACKGROUND End points used to detect influenza in vaccine efficacy trials have varied. Both the inactivated and live attenuated influenza vaccines are efficacious; however, failure to protect occurs. METHODS We compared characteristics of influenza A (H3N2) and B cases from 3 years of a comparative placebo-controlled trial of inactivated and live attenuated vaccines, and we evaluated the laboratory end points used to determine efficacy. RESULTS Although illness duration and reported symptoms did not differ by intervention, subjects with influenza in the inactivated vaccine group were less likely than those in the placebo group to report medically attended illnesses. All influenza type A (H3N2) and B cases isolated in cell culture were also identified by real-time polymerase chain reaction (rtPCR). However, only 69% of type A (H3N2) cases identified by rtPCR also were isolated in cell culture. Isolation frequency was lowest among live attenuated vaccine failures, a reflection of lower specimen viral loads. Among cases of rtPCR identified influenza A (H3N2), 90% of placebo and 87% of live attenuated vaccine recipients but only 23% of inactivated vaccine recipients demonstrated serologic confirmation of infection. CONCLUSIONS In influenza vaccine efficacy studies, virus identification using rtPCR is the ideal end point. Isolation in cell culture will miss cases, and a serologic end point alone will overestimate inactivated vaccine efficacy.
The functional role of platelets in the regulation of angiogenesis

Abstract Functionally, platelets are primarily recognized as key regulators of thrombosis and hemostasis. Upon vessel injury, the typically quiescent platelet interacts with subendothelial matrix to regulate platelet adhesion, activation and aggregation, with subsequent induction of the coagulation cascade forming a thrombus. Recently, however, newly described roles for platelets in the regulation of angiogenesis have emerged. Platelets possess an armory of pro- and anti-angiogenic proteins, which are actively sequestered and highly organized in α-granule populations. Platelet activation facilitates their release, eliciting potent angiogenic responses through mechanisms that appear to be tightly regulated. In conjunction, the release of platelet-derived phospholipids and microparticles has also earned merit as synergistic regulators of angiogenesis. Consequently, platelets have been functionally implicated in a range of angiogenesis-dependent processes, including physiological roles in wound healing, vascular development and blood/lymphatic vessel separation, whilst facilitating aberrant angiogenesis in a range of diseases including cancer, atherosclerosis and diabetic retinopathy. Whilst the underlying mechanisms are only starting to be elucidated, significant insights have been established, suggesting that platelets represent a promising therapeutic strategy in diseases requiring angiogenic modulation. Moreover, anti-platelet therapies targeting thrombotic complications also exert protective effects in disorders characterized by persistent angiogenesis.