Miracle-dz/UniFAR-FTUs huggingface dataset:
Reasonable accommodation.

The term "reasonable accommodation" means actions taken which permit an employee, prospective employee or member with a disability to perform in a reasonable manner the activities involved in the job or occupation sought or held and include, but are not limited to, provision of an accessible worksite, acquisition or modification of equipment, support services for persons with impaired hearing or vision, job restructuring and modified work schedules; provided, however, that such actions do not impose an undue hardship on the business, program or enterprise of the entity from which action is requested.
Cloning and Characterization of Dfak56, a Homolog of Focal Adhesion Kinase, in Drosophila melanogaster*

The focal adhesion kinase (FAK) protein-tyrosine kinase plays important roles in cell adhesion in vertebrates. Using polymerase chain reaction-based cloning strategy, we cloned aDrosophila gene that is homologous to the vertebrate FAK family of protein-tyrosine kinases. We designated this geneDfak56 and characterized its gene product. The overall protein structure and deduced amino acid sequence of Dfak56 show significant similarity to those of FAK and PYK2. Dfak56 has in vitro autophosphorylation activity at tyrosine residues. Expression of the Dfak56 mRNA and the protein was observed in the central nervous system and the muscle-epidermis attachment site in the embryo, where Drosophilaposition-specific integrins are localized. The results suggest that like FAK in vertebrates, Dfak56 functions downstream of integrins. Dfak56 was tyrosine-phosphorylated upon integrin-dependent attachment of the cell to the extracellular matrix. We conclude that the Dfak56 tyrosine kinase is involved in integrin-mediated cell adhesion signaling and thus is a functional homolog of vertebrate FAK.
J-REED: Joint Relation Extraction and Entity Disambiguation

Information extraction (IE) from text sources can either be performed as Model-based IE (i.e, by using a pre-specified domain of target entities and relations) or as Open IE (i.e., with no particular assumptions about the target domain). While Model-based IE has limited coverage, Open IE merely yields triples of surface phrases which are usually not disambiguated into a canonical set of entities and relations. This paper presents J-REED: a joint approach for entity disambiguation and relation extraction that is based on probabilistic graphical models. J-REED merges ideas from both Model-based and Open IE by mapping surface names to a background knowledge base, and by making surface relations as crisp as possible.
A novel resource reservation scheme for handoff in CDMA wireless cellular networks

A novel resource reservation scheme for handoff priority in code division multiple access (CDMA) wireless cellular networks is proposed. The reservation scheme is derived by minimizing a grade of service (GoS) objective function which adjoins new call blocking probability and handoff call dropping probability through an arbitrary multiplier. The system capacity is optimized by minimizing the GoS function and jointly taking call level GoS and packet level quality of service (QoS) into consideration. The resultant reservation scheme is implemented adaptively using user mobility information and variation in traffic load. Numerical results show that, with the satisfaction of new call blocking probability and GoS performance, cell capacity and cell utilization are significantly improved relative to a resource reservation scheme in which only the call level characteristics are taken in to account.
The role of heritage tourism in attracting “active” in-migrants to “low amenity” rural areas

Tourism can influence in-migration to rural areas by enhancing the attractiveness of rural communities and providing opportunities for employment, entrepreneurship and volunteer engagement appealing to in-migrants. Much research on the rural tourism-migration nexus has focused on “high amenity” areas characterized by scenic environments and well-developed tourism and service infrastructures. Many communities in inland Australia, however, are in “low amenity” areas where tourism opportunities are limited to exploiting industrial and cultural heritage assets. This article examines the role of heritage tourism in facilitating in-migration to such areas based on interviews with in-migrants to three communities in South Australia’s Mid-North, focusing on the experiences of “active” in-migrants who get economically or socially involved in their new communities. Findings suggest heritage tourism minimally affected migration decisions. Key attractors were housing, employment, cost of living and easy access to the city. Business opportunities in tourism were attractors where the tourism industry was relatively well developed. Overall, the factors influencing in-migration differed among communities suggesting locally, not regionally, focused place marketing strategies are required to target in-migrants.
Monetary Policy Under Behavioral Expectations: Theory and Experiment

Expectations play a crucial role in modern macroeconomic models. We consider a New Keynesian framework under rational expectations and under a behavioral model of expectation formation. We show how the economy behaves in the alternative scenarios with a focus on inflation volatility. Contrary to the rational model, the behavioral model predicts that inflation volatility can be lowered if the central bank reacts to the output gap in addition to inflation. We test the opposing theoretical predictions in a learning-to-forecast experiment. The results support the behavioral model and the claim that output stabilization can lead to less volatile inflation.
Motion planning amidst planar moving obstacles

A method is investigated for finding a collision-free path for a mobile robot with a few degrees of freedom in a time-varying domain. The environment contains a set of obstacles with arbitrary known motion patterns. In a time-varying environment, paths are time-dependent, i.e., a path needs to be specified as a function of time, since connectivity in the environment changes over time. Given a time-varying environment, a start time, and a start location, a method is presented for finding a collision-free path from start to goal points for a finite-size robot subject to a speed bound. Our method makes use of a heuristic approach based on a transient pixel representation. <<ETX>>
Comparison among Inbreeding Systems in Maize

The use of less severe inbreeding systems than self-fertilization has been suggested as a means of developing more vigorous maize lines (Zea mays L.). To compare different inbreeding systems, nine traits were evaluated in inbred lines developed by full-sib mating (F=0.5), self-fertilization (F=0.5), half-sib mating (F= 0.305), from the following populations: BR 105, a synthetic variety, and ESALQ-PB 4 , which is a composite of wide genetic base. The means and genetic parameters comparisons showed no important advantages of full-sib crosses over selfing. The inbreeding depression values for grain yield were similar between these groups of lines and inferior for half-sib lines. The inbreeding depression rates / 1% of expected homozigosity were similar among the three inbreeding systems. We conclude, in view of large inbreeding depression showed by tropical populations of maize in Brazil, that it is more reasonable to allocate resources and time in breeding source populations than to use milder forms of inbreeding.
The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells

Notch1 is required to generate the earliest embryonic hematopoietic stem cells (HSCs), and Notch-deficient embryos die early in gestation. Gerhardt et al. show that, unlike Notch1-deficient mice, mice lacking the Notch1 transcriptional activation domain (TAD) survive until late gestation. Notch1 TAD-deficient HSCs emerge and successfully migrate to the fetal liver but are decreased in frequency by E14.5. The Notch1 TAD is important to properly assemble the Notch1/Rbpj/Maml transcription complex. These results reveal an essential role for the Notch1 TAD in fetal development.
Intra-Operative Visualizations: Perceptual Fidelity and Human Factors

With increasing capability and complexity of surgical interventions, intra-operative visualization is becoming an important part of a surgical environment. This paper reviews some of our recent progress in the intelligent use of pre- and intra-operative data for enhanced surgical navigation and motion compensated visualization. High fidelity augmented reality (AR) with enhanced 3D depth perception is proposed to provide effective surgical guidance. To cater for large scale tissue deformation, real-time depth recovery based on stereo disparity and eye gaze tracking is introduced. This allows the development of motion compensated visualization for improved visual perception and for facilitating motion adaptive AR displays. The discussion of the paper is focused on how to ensure perceptual fidelity of AR and the need for real-time tissue deformation recovery and modeling, as well as the importance of incorporating human perceptual factors in surgical displays.
Mineral and Bone Disease in Black African Hemodialysis Patients: A Report From Senegal

Background Chronic kidney disease related mineral and bone disease (CKD-MBD) is a worldwide challenge in hemodialysis patients. In Senegal, number of dialysis patients is growing but few data are available about their bone disorders. Objectives To describe patterns of CKD-MBD in Senegalese dialysis patients. Patients and Methods We performed a cross-sectional study including patients from three dialysis centres in Senegal. Diagnosis of different types of CKD-MBD relied on clinical, biological and radiological data collected from medical records in dialysis. Results We included 118 patients and 79 of them presented CKD-BMD (prevalence of was 66.9 %). Mean age of CKD-MBD patients was 47.8 ± 15.7 years (16-81 years) and sex-ratio (Male/Female) was 1.15. Secondary hyperparathyroidism was the most frequent disorder (57 patients) followed by adynamic bone disease (21 patients) and osteomalacia (1 patients). The main clinical manifestations were bone pain (17.5% of cases), pruritus (36.8% of cases) and pathological fractures (2.5% of cases). Bone biopsy was not available. Valvular and peripheral vascular calcification were present in 24.5% and 21.2% of patients respectively. Management of CKD-MBD included optimization of dialysis, calcium bicarbonate, sevelamer, vitamin D analogues and calcimimetics. The NKF/DOQI recommended levels of serum calcium, phosphate and parathormone PTH were not achieved in one third of patients. Six patients presented major cardiovascular events during their dialysis period. Conclusions CKD-MBD are frequent in Senegalese hemodialysis patients and they are dominated by high turn-over disease. Clinical and biological manifestations are unspecific and accurate diagnoses are often difficult in absence of histomorphometry. Treatment is suboptimal for many patients in a context of limited resources.
Consumers' self-congruence with a 'Liked' brand: cognitive network influence and brand outcomes

Purpose Brand “Likes” on Facebook facilitate self-expression, forming part of consumers’ virtual selves. Yet, consumers’ brand “Likes” may bear little resemblance to their material realities. This paper aims to test similarities of brand image with self-image for Facebook “Likes” to determine whether self-congruence with a “Liked” brand leads to positive offline brand outcomes. It also investigates whether consumers’ perceptions about their Facebook social relations influence self-congruent brand “Likes”. Design/methodology/approach A large-scale survey was conducted of regular Facebook users who “Liked” brands. Data from 438 respondents was analysed and hypotheses tested using structural equation modeling. Findings Empirical results show that the perceived self-congruence with a “Liked” brand increases with social tie strength. Perceived social tie strength is informed by perceived attitude homophily. When the perceived self-congruence with a “Liked” brand is higher, brand love and word of mouth (WOM) are enhanced. Consumers also have greater brand loyalty and offer more WOM when brands are loved. Research limitations/implications Findings demonstrate the influence of consumers’ cognitive network on “Likes” and brand outcomes. Further replication would enhance generalisability. Future research should use a wider sample and investigate other variables. Practical implications Findings support managers seeking to grow and analyse Facebook “Likes” by providing insights into brand loyalty, brand love and WOM for “Liked” brands. Originality/value The paper addresses the dearth of research exploring how consumers’ perceptions of their Facebook network influence their online brand behaviour and how perceived self-congruence with a “Liked” brand relates to brand outcomes.
Embryonic stem cells and transgenic mice ubiquitously expressing a tau-tagged green fluorescent protein.

We have generated embryonic stem (ES) cells and transgenic mice carrying a tau-tagged green fluorescent protein (GFP) transgene under the control of a powerful promoter active in all cell types including those of the central nervous system. GFP requires no substrate and can be detected in fixed or living cells so is an attractive genetic marker. Tau-tagged GFP labels subcellular structures, including axons and the mitotic machinery, by binding the GFP to microtubules. This allows cell morphology to be visualized in exquisite detail. We test the application of cells derived from these mice in several types of cell-mixing experiments and demonstrate that the morphology of tau-GFP-expressing cells can be readily visualized after they have integrated into unlabeled host cells or tissues. We anticipate that these ES cells and transgenic mice will prove a novel and powerful tool for a wide variety of applications including the development of neural transplantation technologies in animal models and fundamental research into axon pathfinding mechanisms. A major advantage of the tau-GFP label is that it can be detected in living cells and labeled cells and their processes can be identified and subjected to a variety of manipulations such as electrophysiological cell recording.
Fabrication of integration-capable surface-relief VCSEL arrays for miniaturized optical manipulation of microparticles

Recently, optical manipulation combined with microfluidics has gained increasing interest in the field of biological sciences. This combination enables fast and inexpensive sample analysis and manipulation with reduced consumption of analytes. Another important factor in biology and medicine is the contamination-free handling of micrometer sized biological cells that makes the combination an attractive tool for the researchers. In recent years, the use of VCSELs (vertical-cavity surface-emitting lasers) as light sources in optical manipulation has got significant attention for their various advantages like the possibility of two-dimensional VCSEL array formation and their integration capability that enable parallel particle manipulation and miniaturization, respectively. In this paper, we present the fabrication of the integration-capable VCSEL arrays to form a VCSEL-based miniaturized optical trap module. To enhance the suitability of the VCSELs for optical trapping, we fabricate AlGaAs-GaAs-based surface-relief VCSEL arrays with a very small device pitch.
Hybrid Food Preservation Program Improves Food Preservation and Food Safety Knowledge

The growing trend in home food preservation raises concerns about whether the resulting food products will be safe to eat. The increase public demand for food preservation information led to the development of the comprehensive food preservation program, Preserve the Taste of Summer (PTTS). PTTS is a comprehensive hybrid food preservation program comprised of online lessons and corresponding in-person workshops. PTTS participants reported increases in knowledge about food preservation food safety and recommended food preservation techniques after participating.
Estimation of the micro-motion parameters of a missile warhead using a micro-Doppler profile

This paper deals with the problem of estimating micro-motion parameters. The proposed algorithm uses independent-component analysis to decompose the received signals into individual scatterer signals, and uses particle-swarm optimization to estimate the micro-motion parameters in a micro-Doppler profile. Simulation results show that the proposed method can successfully estimate micro-motion parameters of a warhead model consisting of many point scatterers.
Distribution, Directional, structural and concavity features for historical Arabic handwritten recognition: a comparative study

In the process of automatic handwritten recognition especially in Arabic historical documents, the feature extraction is an important step, which find a set of measured values that accurately discriminate the input handwritten words or characters. In this paper, we try to determine how features designed for Arabic handwritten recognition can be efficient in Arabic historical documents by conducting a comparative study of four types of features (distribution, directional, structural and concavity features). The recognition process is based on Hidden Markov models with HTK toolkit and sliding window features. Words HMMs are learned using embedded training based on character HMM models. Experiments are performed on the benchmark Iben Sina database of Arabic historical documents.
Incidence, predictors, and subsequent mortality risk of recurrent myocardial infarction in patients following discharge for acute myocardial infarction.

BACKGROUND In the percutaneous coronary intervention (PCI) era, little evidence exists regarding the incidence, predictors and long-term mortality of recurrent myocardial infarction (Re-MI) following discharge for acute myocardial infarction (AMI). METHODS AND RESULTS A total of 7,870 patients who survived AMI were studied with a median follow-up period of 3.9 years: 353 patients (4.5%) experienced Re-MI, with 7 of those dying within 30 days, which was classified as fatal Re-MI. The incidence of Re-MI per year was 2.65% for the first year, and 0.91-1.42% thereafter up to 5 years. Multivariate Cox regression analyses revealed that predictors of Re-MI were diabetes mellitus (hazard ratio (HR): 2.079, P<0.001), history of MI (HR: 1.767, P=0.001), and advanced age (HR: 1.021, P=0.001). These 3 predictors remained significant when angiographic and procedural parameters were incorporated into the analyses. The incidence and adjusted risk of Re-MI increased when these variables were clustered (P<0.001). The all-cause mortality rate was significantly higher in patients with Re-MI than in those without (HR: 2.206, P<0.001). CONCLUSIONS In post-AMI patients treated in the PCI era, the incidence of Re-MI is low compared with that reported during the past 30 years. Patients' clinical factors of diabetes mellitus, history of MI, and advanced age appear to affect the occurrence of Re-MI after hospital discharge, and Re-MI still carries a risk for subsequent mortality.
Usability Management System (USEMATE): A web-based automated system for managing usability testing systematically

Usability testing is necessary to be performed by software development companies to determine whether their products are usable or not. It is equally important for the end-user companies running usability studies as well. This paper presents the development of Usability Management System (USEMATE), an automated system as an alternative solution to assist usability tester or practitioner to run usability testing more efficiently and effectively. The main objective of USEMATE is to enhance the current systems which are paper-based, involving manual score calculation using excel and manual response time recording into a web-based management system. The tools used for the development include Apache Web Server, Adobe Photoshop CS2, Adobe Dreamweaver CS3 and a personal computer (PC). The modules and usability criteria included and the approach used in the development of this automated system were replicated from a case study on usability testing of a webpage conducted earlier. USEMATE is envisaged to be able to decrease the lengthy working hour and energy needed to manage the usability testing process from phase to phase.
BANK1 Controls CpG-Induced IL-6 Secretion via a p38 and MNK1/2/eIF4E Translation Initiation Pathway

BANK1, an adaptor protein expressed in B cells, plays a little understood role in B cell signaling. Because BANK1 contains an N-terminal putative Toll/IL-1R receptor domain, we used mouse Bank1−/− splenic B cells to test whether BANK1 affects signaling induced by the TLR9 agonist CpG. Following CpG stimulation, BANK1 deficiency reduced p38 phosphorylation without affecting that of ERK or JNK and reduced IL-6 secretion. Bank1−/− B cells showed reduced phosphorylation of MNK1/2 and eIF4E, suggesting an effect on translation initiation, whereas Bank1−/− had no effect on IL-6 mRNA stability, thus suggesting that BANK1 has no effect on MK2 signaling. IL-6 secretion observed when CpG stimulation was combined with anti-CD40 was reduced in the absence of BANK1. Whereas in the presence of anti-CD40 stimulation CpG induced a stronger phosphorylation of AKT, mTOR, and 4E-BP1, Bank1−/− had no effect on phosphorylation of mTOR and 4E-BP1, and a weak effect on AKT, implying that BANK1 does not affect the release of eIF4E by phospho–4E-BP1. Taken together, these data establish a previously unrecognized role for BANK1 in CpG-induced responses by splenic B cells on p38 signaling and control of translation initiation of IL-6 via MNK1/2 and eIF4E.
Monitoring Customer Relationship in E-Commerce: Which Drivers and Which Effects on Buying Behavior

Customer loyalty has become a major objective for e-tailers. Crossing attitudinal data with behavioral data from two e-tailers (N = 1,796), this research (1) identifies and measures eight relational drivers (aesthetic design, choice, contact, privacy, customization, fulfillment, interactivity, community), (2) underlines their different impacts on the two facets of trust (e-tailers' perceived reliability and benevolence), and (3) demonstrates the total mediating role of relationship commitment between the relational drivers and actual customer patronage behavior.
AMINO ACID TRANSPORTERS IN DRUG DISCOVERY

Administered drugs interact with membrane transporters of epithelia, Blood Brain Barrier and other districts influencing their delivery and efficacy. Drugs can also be used as inhibitors of transporters involved in human pathology. Drug-transporter interactions are responsible of off-target effects contributing to toxicity. High Throughput Screening technologies increased the potential applications in therapy or in predicting side effects. These strategies will be helpful in reducing animal experimentation. The identification of transporters important for drug absorption, delivery and side effect production and the best technologies for studying interactions are the main goals in this field. Amino acid transporters are not yet considered in human therapy in spite of their involvement in several pathologies. The function of the amino acid transporters EAAT1, ASCT2, GLYT2, GLYT1, B0AT1, LAT1 and LAT2 is so far well characterized. Some structural data on these transporters have also been obtained by bioinformatics. Interactions of these proteins with several drugs have been well defined at the molecular level. Large scale and, in some cases, high throughput screening of pharmacological compounds make these transporters of particular interest and potential application in human health.