Miracle-dz/UniFAR-FTUs huggingface dataset:
Étude des mécanismes d'action de la prolactine dans les cellules de la prostate : implication sur la prolifération

Parmis ses nombreuses activites, la prolactine est notamment impliquee dans le controle de la proliferation cellulaire. Cependant les mecanismes d'action de la prolactine, et tout particulierement au niveau ionique, qui conduisent a la proliferation des cellules de la prostate ne sont pas encore reellement elucides. Nos travaux montrent que la prolactine favorise la proliferation des cellules cancereuses prostatiques par l'intermediaire de canaux potassiques, lesquels sont de facon generale relativement bien impliques dans la regulation de la proliferation. Le calcium etant considere comme le second messager principal de la regulation de la proliferation, nous montrons que la prolactine favorise la proliferation des cellules prostatiques normales en surexprimant les pompes reticulaires SERCA 2b ainsi que des canaux membranaires TRPC impliques dans l'homeostasie calcique. Enfin nous montrons que la variation d'expression des formes des recepteurs de la prolactine peuvent expliquer ces differences de voies de signalisation pour la proliferation induite par la prolactine entre les cellules normales et les cellules cancereuses la forme longue du recepteur ne varie pas alors que l'expression de la forme courte est differente selon les pathologies prostatiques.
Identification of freight patterns via association rules: the case of agricultural grains.

The road system is the main form of transport in the biggest production regions between the domestic market and exporting. ports, as well as the transport used on intermodal routes connecting production areas with rail and/or water terminals. The goal of the current study is to recognize non-obvious patterns in a mass of data for road freights of selected grain: soy and corn. As such, the data mining technique, known as the Apriori algorithm, is used to generate association rules that describe such patterns. Among the varied rules identified by this technique, we highlight those that enable us to conclude that: i. Soy and corn production in the state of Mato Grosso is carried via the port of Santos; ii. The grain storage silos located in the state of Mato Grosso mainly receive shipments from the same state; iii. The port of Sao Francisco do Sul, mainly receives corn; iv. In the state of Minas Gerais there is an intermodal route that receives the grain originating mostly from Mato Grosso and transfers it to the rail system, which then carries the load to its next destination.
Proteomic Identification of the Involvement of the Mitochondrial Rieske Protein in Epilepsy

Summary: Purpose: Kindled seizures are widely used to model epileptogenesis, but the molecular mechanisms underlying the attainment of kindling status are largely unknown. Recently we showed that achievement of kindling status in the Sprague–Dawley rat is associated with a critical developmental interval of 25 ± 1 days; the identification of this long, well‐defined developmental interval for inducing kindling status makes possible a dissection of the cellular and genetic events underlying this phenomenon and its relation to normal and pathologic brain function.
Comparative study of swarm intelligence-based saliency computation

Purpose The purpose of this paper is to propose a new algorithm chaotic pigeon-inspired optimization (CPIO), which can effectively improve the computing efficiency of the basic Itti’s model for saliency-based detection. The CPIO algorithm and relevant applications are aimed at air surveillance for target detection. Design/methodology/approach To compare the improvements of the performance on Itti’s model, three bio-inspired algorithms including particle swarm optimization (PSO), brain storm optimization (BSO) and CPIO are applied to optimize the weight coefficients of each feature map in the saliency computation. Findings According to the experimental results in optimized Itti’s model, CPIO outperforms PSO in terms of computing efficiency and is superior to BSO in terms of searching ability. Therefore, CPIO provides the best overall properties among the three algorithms. Practical implications The algorithm proposed in this paper can be extensively applied for fast, accurate and multi-target detections in aerial images. Originality/value CPIO algorithm is originally proposed, which is very promising in solving complicated optimization problems.
The Theoretical Aspect of Management Culture as Part of Organizational Culture

This chapter introduces the theoretical concept of the management culture. The management culture is discussed as an integral element of organizational culture, which ensures a qualitative functionality of the processes within the organization and enables the changes in the organizational culture and the competitive advantage. Management culture is not identical to organizational culture, as it covers certain parts of formal and informal organizational culture. Management, educational, information, communication, standardization and regulatory, and other functions of the management culture and the categories comprising this phenomenon of the organization are distinguished.
A Multi-Case Study of Entrepreneurial Competencies in Microenterprises

Building on a theoretical framework of integrated entrepreneurial competencies with substantial literature supported by Baron and Ensley (2006), Bartlett and Ghoshal (1997), Karra, Nelson and Tracey (2008), Man, Lau and Chan (2002), and McGregor et al. (2000), this study conceptually interpreted a framework of entrepreneurial competencies in microenterprises through conducting a multi-case qualitative method. By collecting and analyzing related documentation, reviewing literature, and observing researchers' observations and participants involved the study identified six key entrepreneurial competencies in microenterprises i.e., opportunity exploration competencies, opportunity exploitation competencies, organizing competencies, strategic competencies, relationship competencies, and commitment competencies. As a result, the researchers provided the structure for further research for the practice and advancement of micro-entrepreneurship.
FUTURE DIRECTIONS IN THE STORAGE RING DEVELOPMENT

Major performance objectives for storage-ring based light sources are small emittance and energy spread, high beam stability, and full exploitation of the photon energy from a few eV up to hard X-rays. Most of the recent- generation light sources are built up by highly optimized lattices of the Double Bend- or Triple Bend Achromat type. There is little room left to further optimize these lattices to even smaller emittances. Only a local adjustment of the optics at the source points might still bring some benefit. With decreasing emittance orbit stability is becoming more and more important. Cures for vibrations, thermal effects and ground motion have to start at the basic design of the building, the storage ring infrastructure and the magnet support system. Beam instabilities are especially harmful as they increase the energy spread and as a consequence deteriorate the higher harmonics of the undulator radiation. Well optimized beams suffer from lifetime problems due to Touschek scattering. Particular problems arise when short bunches are requested, for instance for storage ring based lasers. Medium-energy machines are able to produce high brilliance in the hard X-ray range by means of mini-undulators with small gaps. This, again, has an adverse effect on the beam lifetime due to beam gas scattering. The current trend in storage ring development for future Light Sources is discussed. What are the crucial issues and where is improvement desirable and possible? Is there still room for improving the basic design of a light source? Are there alternatives to the ’classical’ lattices which could be used for the next generation? Or is improvement possible only on the operational field?
Dynamic Diluted Taint Analysis for Evaluating Detected Policy Violations

Dynamic taint analysis is a well-known technique. This article describes some difficulties that have to be dealt with when using dynamic taint analysis with full-system emulation. A new method is proposed to evaluate the risk of a detected policy violation. The method is called Diluted Taint: each tainted byte has an assigned integer value that shows how much taint resides in this byte. High value represents fresh taint, that possesses more threat, low value means that many operations occurred with this fragment of data and it is not that dangerous. When a policy violation occurs, these values are used by an expert to quickly evaluate the potential threat and prioritize fixing dangerous ones first.
From Conception to Start-Up: Who and What Affect Female Entrepreneurship

This study explores the early stages of the female entrepreneurial process from conception to venture start up. Seventy-eight female entrepreneurs’ stories, published on the Flying Goose Program website, were collected and analyzed by content. Engaged in different industries, they are mostly small- and medium-sized enterprises or micro-enterprises in personal service industry. The results describe the women entrepreneur as: middle-aged, married, college degree, with work experience, no management experience, no financial backup, mostly in traditionally personal service industry. In addition to their dreams, interests, and specific skills and knowledge, these women have a desire to solve life problems or assist disadvantaged groups in society. When they have an entrepreneurial idea, they are likely to share it with and receive approval and affirmation from their families—particularly their husbands. Government assistance is a major factor affecting their venture start up decision making. They access related business knowledge from training courses. Practical and policy implications for female entrepreneurship are provided. To cite this document: Ting-Ling Lin, Tzu-Ying Lu, Mei-Chen Hsieh, Heng-Yih Liu, "From Conception to Start-Up: Who and What Affect Female Entrepreneurship", Contemporary Management Research, Vol.14, No.4, pp. 253-276, 2018. Permanent link to this document: http://dx.doi. org/10.7903/cmr.17957
D.1 Feasibility and impact of palliative care at any stage of amyotrophic lateral sclerosis

Background: Although palliative care (PC) is recommended for patients with amyotrophic lateral sclerosis (ALS), many patients receive PC very late or not at all. Our study goals included 1) determing the feasibility of early PC 2) describing patient/caregiver satisfaction with early PC and 3) measuring the impact of early PC on quality of life (QOL) and mood. Methods: Patients followed at the multidisciplinary ALS clinic in Ottawa, Canada and their caregivers were eligible for the study irrespective of duration or severity of disease. All participants completed questionnaires tracking QOL and mood and all were offered a palliative care consultation. Participants completed a satisfaction survey post-PC consultation. Results: 32 patients and 20 caregivers received a PC consultation, conducted virtually. All of them found the consult beneficial and none of the patients reported preferring the consultation later in their illness. The PC consultations were most highly rated by patients with high levels of anxiety and worse bulbar function, and by caregivers of patients with low function. There was no statistically significant change in mood or QOL compared to the 7 participants who declined PC consultation. Conclusions: PC consultations are feasible and beneficial at all stages of illness. Patients with anxiety and bulbar dysfunction may benefit most.
Rethinking piaget for a developmental robotics of object permanence

Piaget's account of object permanence development is rethought in light of both its historical roots in Poincare's theory of space and current understanding of mechanisms. This rethinking reveals the developmental constraints reflected in Piaget's stages of object permanence, charts the essential interdependence of spatial capacity, memory capacity, embodied movement, and object cognition, exonerates the A-not-B phenomenon from its appearance of an oddity, and provides programmatic guidance for a future robotics of object permanence development.
Determination of diffusing capacity by modeling the dynamics of C/sup 18/O uptake in newborns

Dynamic modeling of lung C/sup 18/O diffusion is used to measure the C/sup 18/O transfer factor (TL/sub co/) of 14 newborns aged 1-4 mo. The model equation is based on the alveolar fractions of C/sup 18/O and on changing alveolar ventilation induced by the rebreathing conditions. The model does not involve the volume of the rebreathing bag which is usually needed when applying rebreathing technique add which is a source of error. The equation is discretized and solved for recorded data obtained with equipment adapted to use in newborns. A least-square parameter calculation technique is applied to estimate TL/sub co/. Results show a strong relationship between this index and the biometrical ones and confirm those found in the literature featuring that the measurement duration can be considerably shortened.
Labor, Delivery, and Early Parenthood

Having a baby is a powerful experience that, according to attachment theory, should activate the attachment system and elicit attachment needs and motives. The current study investigated first-time parents' perceptions of and responses to events surrounding labor and delivery and early parenthood. Couples expecting their first child completed measures of attachment orientations and questionnaires assessing key aspects of the experience of labor, delivery, and early parenthood. Attachment anxiety and avoidance significantly predicted individuals' perceptions of themselves and their partners, reactions to their partners' behavior, and emotional responses to their infants. Jealousy of the infant, perceptions of support given to or received from partners, and feelings of closeness to the infant were all associated with attachment orientations in theoretically meaningful ways.
Design of an emotion aware e-learning system

Sense and analysis of user's emotions has appeared in the focus of the research agenda during the last decade with many applications, especially in learning. The latter is informed by the study of emotions that has been attained for many years. In the current paper, we first review prominent theories and models of learning with respect to student's emotions and emotion recognition technologies and then we analyse the design of a system endowed with emotion awareness features. Part of the work we present, is based on the results of a pilot CSCL project, named emot-project. In our last section, we define an agenda for future work.
Bioluminescent sensors for detection of bioavailable Hg(II) in the environment

Biosensors for the detection of pollutants in the environment can complement analytical methods by distinguishing bioavailable from inert, unavailable forms of contaminants. By using fusions of the well-understood Tn21 mercury resistance operon (mer) with promoterless luxCDABE from Vibrio fischeri, we have constructed and tested three biosensors for Hg(II). Bioluminescence specified by pRB28, carrying merRo/pT, by pOS14, mediating active transport of Hg(II), and by pOS15, containing an intact mer operon, was measured in rich and minimal media. The highest sensitivities were achieved in minimal medium and were 1, 0.5, and 25 nM Hg(II) for pRB28, pOS14, and pOS15, respectively. The utility of the biosensors in natural waters was demonstrated with freshwater, rain, and estuarine samples supplemented with Hg(II). mer-lux carried by pRB28 and pOS14 responded to Hg(II) in mercury-contaminated water samples collected from a freshwater pond. Semiquantitative analyses based on light emission in samples collected from the inlet (analytically determined total mercury, approximately 20 nM) and outlet (total mercury, approximately 7 nM) of the pond showed bioavailable mercury at approximately 20 and 1 to 2 nM, respectively. Thus, the biosensors described here semiquantitatively detect bioavailable inorganic mercury (at a nanomolar to micromolar concentration range) in contaminated waters.
Key Factors Affecting Ambulatory Care Providers’ Electronic Exchange of Health Information With Affiliated and Unaffiliated Partners: Web-Based Survey Study

Background Despite the potential benefits of electronic health information exchange (HIE) to improve the quality and efficiency of care, HIE use by ambulatory providers remains low. Ambulatory providers can greatly improve the quality of care by electronically exchanging health information with affiliated providers within their health care network as well as with unaffiliated, external providers. Objective This study aimed to examine the extent of electronic HIE use by ambulatory clinics with affiliated providers within their health system and with external providers, as well as the key technological, organizational, and environmental factors affecting the extent of HIE use within and outside the health system. Methods A Web-based survey of 320 ambulatory care providers was conducted in the state of Illinois. The study examined the extent of HIE usage by ambulatory providers with hospitals, clinics, and other facilities within and outside their health care system–encompassing seven kinds of health care data. Ten factors pertaining to technology (IT [information technology] Compatibility, External IT Support, Security & Privacy Safeguards), organization (Workflow Adaptability, Senior Leadership Support, Clinicians Health-IT Knowledge, Staff Health-IT Knowledge), and environment (Government Efforts & Incentives, Partner Readiness, Competitors and Peers) were assessed. A series of multivariate regressions were used to examine predictor effects. Results The 6 regressions produced adjusted R-squared values ranging from 0.44 to 0.63. We found that ambulatory clinics exchanged more health information electronically with affiliated entities within their health system as compared with those outside their health system. Partner readiness emerged as the most significant predictor of HIE usage with all entities. Governmental initiatives for HIE, clinicians’ prior familiarity and knowledge of health IT systems, implementation of appropriate security, and privacy safeguards were also significant predictors. External information technology support and workflow adaptability emerged as key predictors for HIE use outside a clinic’s health system. Differences based on clinic size, ownership, and specialty were also observed. Conclusions This study provides exploratory insights into HIE use by ambulatory providers within and outside their health care system and differential predictors that impact HIE use. HIE use can be further improved by encouraging large-scale interoperability efforts, improving external IT support, and redesigning adaptable workflows.
Organocatalytic ring-opening polymerization.

Modern synthetic methods have revolutionized polymer chemistry through the development of new and powerful strategies for the controlled synthesis of complex polymer architectures. 1-5 Many of these developments were spawned by new classes of transition metal catalysts for the synthesis of new polyolefin microstructures, 5 the design of highly efficient families of “living” polymerization strategies for the synthesis of block, graft, and star polymers, 6-12 controlled methods for the synthesis of dendritic macromolecules, 3,13,14
Exploiting security, safety and situational related services by using Remotely Piloted Aircrafts

The purpose of this study is to find out what kind of services can be designed by utilizing Unmanned Aircraft Systems (UAS). This study provides an understanding of the current obstacles for producing these services. The legal UAS issues in public and private organizations are examined. The biggest challenge in using Unmanned Aircraft Vehicles (UAVs) is that legislation does not recognise enough a UAV as an aircraft. Training and other requirements for the operator and the actual flyer are unspecified for UASoperations. UAVs development is waiting for standardization. The aim of this research is to analyze and assemble summary about this issue by using data triangulation. From the research perspective there are needs for UAS and also social general ignorance how UAS can be exploit in civilian use. Challenge for cooperation in this particular case is to reconcile the needs of different actors public and private under common interests. The market has a huge economic promise for different UAS classes. By other means than utilizing UAS, the same benefits are difficult to be achieved; therefore societal benefits are particularly high. UAS would significantly increase the number of the biggest priorities of safety, security and environmental issues. Key-Words: Legislation, public, private, unmanned aircraft system, unmanned aerial vehicle, service provider
Safety and benefits of distance‐adjusted prefrontal transcranial magnetic stimulation in depressed patients 55–75 years of age: A pilot study

In contrast to the effects seen in younger adults, depressed elderly subjects have shown more modest antidepressant responses to transcranial magnetic stimulation (TMS). We theorized that higher stimulation intensities in older depressed subjects with prefrontal atrophy might be needed to stimulate underlying cortex. In an open design with patients on stable baseline medications, we treated 18 treatment‐resistant elderly depressed subjects (mean age 61.2±7.3) with 15 rTMS sessions over 3 weeks. We adjusted the delivered TMS intensity to account for MRI measured prefrontal atrophy. The skull to prefrontal cortex distance increased with age, whereas the skull to motor cortex distance did not. All subjects tolerated the higher doses well. The average intensity used was 114% of motor threshold (MT) with a range from 103–141% MT. There was an average 35% decline over the 3 weeks in HRSD scores. After 3 weeks of treatment, 27% (5/18) met response criteria (>50% improvement), with four of these five also meeting criteria for remission (exit Hamilton Depression Score <8). These initial pilot findings support the need for blinded studies using prefrontal TMS in an elderly population, testing whether TMS, delivered at stimulation intensities calculated to overcome atrophy, is more effective than TMS without adjusting for atrophy. Depression and Anxiety 19:249–256, 2004. © 2004 Wiley‐Liss, Inc.