Miracle-dz/UniFAR-FTUs huggingface dataset:
Phosphorylation by a Cyclin-Dependent Kinase Modulates DNA Binding of the Arabidopsis Heat-Shock Transcription Factor HSF1 in Vitro

Phosphorylation is one of the mechanisms controlling the activity of heat-shock transcription factors in yeast and mammalian cells. Here we describe partial purification, identification, and characterization of a protein kinase that phosphorylates the Arabidopsis heat-shock factor AtHSF1 at multiple serine residues. The HSF1 kinase forms a stable complex with AtHSF1, which can be detected by kinase pull-down assays using a histidine-tagged AtHSF1 substrate. The HSF1 kinase interacts with the cell-cycle control protein Suc1p and is immunoprecipitated by an antibody specific for the Arabidopsis cyclin-dependent CDC2a kinase. Phosphorylation by CDC2a in vitro inhibits DNA binding of AtHSF1 to the cognate heat-shock elements, suggesting a possible regulatory interaction between heat-shock response and cell-cycle control in plants.
Desulfovibrio vulgaris CbiKP cobaltochelatase: evolution of a haem binding protein orchestrated by the incorporation of two histidine residues

The sulfate-reducing bacteria of the Desulfovibrio genus make three distinct modified tetrapyrroles, haem, sirohaem and adenosylcobamide, where sirohydrochlorin acts as the last common biosynthetic intermediate along the branched tetrapyrrole pathway. Intriguingly, D. vulgaris encodes two sirohydrochlorin chelatases, CbiKP and CbiKC , that insert cobalt/iron into the tetrapyrrole macrocycle but are thought to be distinctly located in the periplasm and cytoplasm respectively. Fusing GFP onto the C-terminus of CbiKP confirmed that the protein is transported to the periplasm. The structure-function relationship of CbiKP was studied by constructing eleven site-directed mutants and determining their chelatase activities, oligomeric status and haem binding abilities. Residues His154 and His216 were identified as essential for metal-chelation of sirohydrochlorin. The tetrameric form of the protein is stabilized by Arg54 and Glu76, which form hydrogen bonds between two subunits. His96 is responsible for the binding of two haem groups within the main central cavity of the tetramer. Unexpectedly, CbiKP is shown to bind two additional haem groups through interaction with His103. Thus, although still retaining cobaltochelatase activity, the presence of His96 and His103 in CbiKP , which are absent from all other known bacterial cobaltochelatases, has evolved CbiKP a new function as a haem binding protein permitting it to act as a potential haem chaperone or transporter.
Approximate dual control maintaining the value of information with an application to building control

Dual control, the simultaneous identification and control of dynamic systems, is an idea that has been around for several decades without being widely used in applications, due to the fundamental intractability of the optimal solution. Available algorithms are either complex and computationally demanding, or reduce to a simple change of the cost function, which can lead to poor average performance. In addition, classic dual control schemes do not deal with constraints and economic cost structures present in many applications. In this paper, we aim at facilitating the use of dual control algorithms based on a series expansion of the cost function for such systems. In particular, this is realized by employing reference tracking of the optimal mean trajectory together with soft constraints. A key feature of the proposed formulation is that it maintains the value of information in the cost, making dual control tractable with all dual features. Evaluation on a simulated building control problem exhibits an advantage of using the proposed dual controller over simplified solutions.
Exploring the Antecedents of Work-to-life Conflict under the Context of Bring Your Own Device

Recently, the rapid adoption of smartphones and tablets among employees has forced organizations to proactively embrace the concept of Bring Your Own Device (BYOD). Allowing employees to bring their own mobile devices to the workplace has blurred the boundary between work and personal life and therefore created a stressful environment for employees when they are performing both work role and family role. This study explores the influencing factors of work-to-life conflict under the context of BYOD. A new construct workplace connectivity was introduced to the BYOD attributes model. Based on the boundary theory, a theoretical model with eight hypotheses was developed.
Challenges of continuous technological disruption in the broadcasting industry and the search for ‘job-fit’ talents

:Job placement is becoming an uphill task for new graduates when they do not have the relevant knowledge to start up on their own. This happens when their education is either sub-standard, rendered obsolete upon graduation or cannot be translated into practice at their respective workplaces. Such a shortcoming in the broadcasting industry is not with the provision of training or the supply of skilled manpower. It is rather the continuous disruption of technology when graduates require more than operational knowledge. In the absence of ‘job-fit graduates’ the broadcasting industry looks out for the best talents outside of their traditional marketplace. To address this fallout, the industry is looking to recruit new talents with emerging computing knowledge instead of the traditional Mass Communication discipline. This empirical study explores the skills shortage in the broadcasting industry from the perspective of “Challenges of Industrial Revolution 4.0 in higher education (MyHE 4.0). Qualitative data was gathered from stakeholders, training providers and vendors. Two major findings: 1) The need for talents transformation to a modern converged setting in broadcasting; and 2) The establishment of pathways to ‘Job-Fit’ training in the broadcasting industry, have emerged from the study. The study proposes six recommendations in support of the transformation in the broadcasting industry.
Improving Video Segmentation by Fusing Depth Cues and the ViBe Algorithm

Depth-sensing technology has led to broad applications of inexpensive depth cameras that can capture human motion and scenes in 3D space. Background subtraction algorithms can be improved by fusing color and depth cues, thereby allowing many issues encountered in classical color segmentation to be solved. In this paper, we propose a new fusion method that combines depth and color information for foreground segmentation based on an advanced color-based algorithm. First, a background model and a depth model are developed. Then, based on these models, we propose a new updating strategy that can eliminate ghosting and black shadows almost completely. Extensive experiments have been performed to compare the proposed algorithm with other, conventional RGB-D algorithms. The experimental results suggest that our method extracts foregrounds with higher effectiveness and efficiency.
Helicopter gearbox vibrations: cyclostationary analysis or bilinear approach?

We show that a nonstationary approach can be preferred to a nonlinear one for the study of some nonlinear phenomena. We prove that the spectral correlation could detect and determine precisely a nonlinear phenomenon. Moreover, in terms of diagnosis on helicopter gearboxes (known for their strong nonlinearity), this tool is much more efficient than the bispectrum. Finally, we introduce an algorithm determining the main nature of a nonlinear cyclic phenomenon. This process is based on the use of higher order cyclic statistics.
Drug use and weight loss in HIV-infected Hispanic men

Abstract Weight loss is an independent risk factor for mortality in HIV but the role of drug use in HIV-related weight loss is not well described. We conducted this study to determine the role of drug use in HIV-related weight loss. Men (n=304), all of whom were Hispanic, were recruited into one of three groups: HIV-infected drug users; HIV-non-infected drug users; and HIV-infected non-drug users. Body mass index (BMI) was measured at successive visits. The groups were re-categorized based on self-reported drug use at the current visit into: (1) users of cocaine alone; (2) users of cocaine and opiates; (3) users of opiates alone; (4) former drug users; and (5) those who denied ever using drugs (all HIV-infected). The effect on BMI of the duration of use of the specific drug types was evaluated using repeated-measures analyses. Longer duration of exclusive opiate use or mixed cocaine and opiate use did not affect BMI in the men, regardless of HIV status. Exclusive cocaine use was associated with a decline in BMI among HIV-infected men (−0.070 kg/m2 per month duration of use; SE=0.033; p=0.037) but not among HIV-uninfected men (0.024 kg/m2 per month; SE=0.023; p=0.29). Adjustment for marijuana, cigarette and alcohol use in all men, or for CD4 count, viral load or HIV medication use in the HIV-infected men, did not alter the conclusions. We conclude that the use of opiates or combined opiates and cocaine does not increase the risk of weight loss in the presence or absence of HIV infection. Exclusive cocaine use may exacerbate weight loss in HIV-infection.
Desengage social media to E-Export: start wintry product using micro blogging information

In recent years, the boundaries among e-commerce and social networking have come to be more and more blurred. Many e-commerce web sites aid the mechanism of social login where customers can sign up the web sites the use of their social community identities which include their Facebook or Twitter money owed. Users can also publish their newly bought merchandise on microblogs with links to the e-commerce product internet pages. In this paper, we recommend a unique answer for move-site cold-begin product recommendation, which aims to recommend merchandise from e-trade websites to customers at social networking web sites in “cold-start” conditions, a trouble which has hardly ever been explored earlier than. An essential challenge is the way to leverage know-how extracted from social networking sites for cross-web site bloodless-start product advice. We propose to apply the connected customers throughout social networking web sites and e-commerce web sites (customers who've social networking debts and have made purchases on e-trade web sites) as a bridge to map customers’ social networking capabilities to any other function illustration for product recommendation. In particular, we advise mastering each customers’ and merchandise’ function representations (known as user embedding’s and product embedding’s, respectively) from facts accrued from e-commerce web sites using recurrent neural networks and then observe a changed gradient boosting trees method to transform users’ social networking capabilities into person embedding’s. We then expand a function-based totally matrix factorization approach which could leverage the learnt user embedding’s for bloodless-begin product recommendation. Experimental effects on a big dataset made out of the biggest Chinese microblogging provider SINA WEIBO and the biggest Chinese B2C e-trade internet site JINGDONG have proven the effectiveness of our proposed framework.
The density of synapses and neurones in the motor and visual areas of the cerebral cortex.

Cortical synapses can be seen by electron microscopy, but their density in tissue sections does not appear to have been estimated. Since the diameter of a synapse is much greater than the section thickness, synaptic profiles must be measured as well as counted to obtain the density. Many authors have counted neurones in tissue sections by light microscopy after staining the Nissl bodies, but in general the tissue shrinkage caused by histological preparation has not been measured. The volume shrinkage with paraffin embedding may be 52 0 (Brizzee, Vogt & Kharetchko, 1964), 73 Oo (Ramon-Moliner, 1961) or even 83% (Robins, Smith & Eydt, 1956) and is variable according to the method of preparation. Many of the published estimates of neuronal density are thus too high by an unknown factor between two and six, and the dependence of this factor on the exact method of preparation makes the comparison of the results of different authors of doubtful validity. Neurones have therefore been counted again in a representative selection of mammals using a method that eliminates shrinkage and yields an absolute density. When the density of synapses and the density of neurones have been estimated on the same tissue, division of one result by the other gives an average value for the number of synapses on each neurone in the tissue. This number has been found to be considerably larger than previous estimates made without electron microscopy, and shows interesting variations between species and in different cortical areas. It is possible that the average number of synapses on each neurone may be a measure of the quality or sophistication of cerebral cortex. This idea derives from the findings of Nissl (1898) on the greater separation of human neurones, compared with those of mole or dog brain, and the remarks of Von Economo (1926) on the greater opportunity for neuronal interaction provided by the more extensive fibre plexus that fills the space between the widely separated neurones. The average number of synapses on each neurone may be a useful parameter to measure in investigating the structural basis of mental retardation, or the question of whether there are detectable structural changes in learning, for example, in the formation of a learning set for visual pattern problems. The motor and visual areas were selected for this study because they can be recognized in all species and probably represent opposite extremes of neo-cortical specialization.
Quality of life after liver transplantation for alcoholic liver disease

There are few data on predictive factors for alcohol relapse or long‐term functional outcome after liver transplantation for alcoholic liver disease (ALD). In all 56 surviving UK patients (47 men, 9 women; mean age: 51 years; range: 33 to 69 years) who underwent transplantation for ALD at King's College Hospital over a 10‐year period, alcohol relapse and outcome were assessed by outpatient and case‐note review and by postal questionnaire containing (1) the Nottingham Health Profile (NHP), (2) the Short‐Form‐36 (SF‐36) Health Survey, and (3) a drug and alcohol questionnaire. At a median of 2.5 years (range: 0.5 to 10 years), 13 of the 47 respondents (28%) and 2 of the 9 nonrespondents (22%) had evidence of potentially harmful drinking (>3 units daily) at some time posttransplantation. An additional 13 patients admitted to drinking some alcohol at least once, corresponding to an overall relapse rate of 50%. The patients with harmful drinking (1) had started drinking regularly at a younger age (18 v 25 years; P = .01), (2) began drinking heavily at a younger age (30 v 40 years; P = .01), (3) had shorter pretransplantation abstinence periods (10 v 23 months; P = .02), and (4) had a longer time since transplantation (median, 5.7 v 1.5 years; P = .0004) than those with no or mild alcohol relapse. They were also more likely to report sleep disturbance (NHP sleep problem score, 45 v 16; P = .01) and use benzodiazepines regularly (7 of 13 v 3 of 34 patients; P = .002). Despite these differences, health dimension scores in the SF‐36 and NHP posttransplantation were similar between the groups and to those of UK community controls. In the long term, at least 50% of the patients will drink again at some time posttransplantation, although at lower levels of alcohol intake than previously. Those patients with multiple predictive factors for alcohol relapse may be at greatest risk for harmful drinking and be the group that would benefit most from professional counseling. Overall, the quality of life after liver transplantation for ALD is high and broadly similar to the levels expected in the normal population.
A Risk Score System to Preoperatively Predict TNM Stages in Gastric Cancer

Background:To improve the estimation of tumor status and facilitate the stage-dependent treatment planning, we developed a reliable and easy-to-use risk score for prediction of tumor-node-metastasis stages in gastric cancer. Methods:Clinicopathological data were collected prospectively from 108 curatively resected patients with gastric cancer. The risk score was established on the basis of independent predictive factors for tumor stages, and its performance was evaluated by receiver operating characteristic (ROC) analysis. Results:The following 4 independent factors were included in our score: serum albumin levels, tumor size, T and N categories determined by helical computed tomography. Using ROC analysis, we chose a score at 7 as the optimal cut point for differentiating the more advanced disease (stage III/IV) from the less advanced one (stage I/II). With the defined cut point, our score allowed predicting stage III/IV with sensitivity of 79.6%, specificity of 85.2%, and accuracy of 82.4%. The discriminative ability of this score was good (the area under the ROC curve, 0.861–0.965). Conclusions:The risk score may be helpful to preoperative gastric cancer staging. It probably assists surgeons in deciding the extent of surgery and in choosing the appropriate perioperative adjuvant therapies.
Liquidity Management and The Islamic Bank Financing Constraints

The major source of income for a bank comes from the financing operations. Insufficient amount of fund resources a bank have, consequently, a negative relationship between liquid assets holding, reserve, capital requirement, and provision for bad and doubtful financing with financing operations is expected. Thus, the study aim to examine the degree of constraint the liquidity management has on the Islamic bank financing activities. To realise the objectives of the study, this study utilised the dynamic panel data, Generalized Method of Moments (GMM) estimator applied to Malaysia Islamic banks annual data for the period of 1998 to 2014. The finding shows a negative relationship between liquidity and financing, which means an insufficient fund, is a constraint to the Islamic bank's financing operations. Thus, the liquid assets holding and securities holdings have a negative impact on Islamic bank financing activities, hence, excessive holding of liquidity consequently will reduce bank’s financing volumes.
Risk factors for cervical presence of human papillomavirus DNA among women at risk for HIV infection

Risk factors for cervical infection with human papillomavirus (HPV) were assessed among 236 Italian women at risk for human immunodeficiency virus (HIV) infection (intravenous drug users (IVDU) or sexual partners of males at risk for HIV infection). All study participants underwent a structured interview, determination of HIV serostatus and detection of HPV cervical infection by means of polymerase chain reaction (PCR). Overall, the cervical presence of HPV DNA was ascertained in 86 of these 236 women (36·4%), while squamous intraepithelial lesions (SIL) were diagnosed in 57 (24·1%). HPV-infected and non-infected women did not differ in age, education and cigarette smoking. A statistically significant trend in the risk of HPV infection with increasing number of lifetime sexual partners was noted (P=0·01), but such trend was attenuated in multivariate analysis (multiple logistic regression (MLR) odds ratio (OR) for [ges ]20 partners vs 1=1·6, 95% confidence intervals (CI): 0·4–5·9). A nearly threefold higher risk of HPV cervical infection emerged among IVDU women (MLR–OR: 2·7, 95% CI: 1·4–5·0), and this difference was not influenced by HIV serostatus. The prevalence of HIV infection was higher among HPV-positive than HPV-negative women (62·8% and 54·0%, respectively) (MLR–OR=1·9, 95% CI: 0·9–3·8), and the proportion of women with less than 200 CD4+ cells/mm3 was slightly and not significantly higher among HPV-positive (47·1%) than negative women (37·2%).
Optical absorption characteristics and polarization dependence of single-layer graphene on silicon waveguide

Graphene is attracting attention in electrical and optical research fields recently. We measured the optical absorption characteristics and polarization dependence of single-layer graphene (SLG) on submicrometer Si waveguide. The results for graphene lengths ranging from 2.5 to 200 μm reveal that the optical absorption by graphene is 0.09 dB/μm with the TE mode and 0.05 dB/μm with the TM mode. The absorption in the TE mode is 1.8 times higher than that in the TM mode. An optical spectrum, theoretical analysis and Raman spectrum indicate that surfaceplasmon polaritons in graphene support TM mode light propagation. key words: graphene, silicon photonics, polarizer, optical absorption
A Corpus-based Multi-label Emotion Classification using Maximum Entropy

Thanks to the Internet, blog posts online have emerged as a new grassroots medium, which create a huge resource of text-based emotion. Comparing to other ideal experimental settings, what we obtained from the World Wide Web evolve and respond more to real-world events. In this paper, our corpus consists of a collection of blog posts, which annotated as multi-label to make the classification of emotion more precise than the single-label set of basic emotions. Employing a maximum entropy classifier, our results show that the emotions can be clearly separated by the proposed method. Additionally, we show that the microaverage F1-scores of multi-label detection increase when the mount of available training data further increases.
Measuring corporate social performance

Business and researchers have paid increasingly more attention to corporate social responsibility (CSR) disclosure in term of their sustainable reports. These disclosures supply information for not only managers in strategic decision-making but also other stakeholders in measuring and evaluating corporate social performance (CSP). Although the development of literature on CSR disclosure, the CSR’s measurement is not yet unified because of different perspective and methodology. The question is how to measure CSP through analyzing CSR disclosure. This paper aims to present theoretical background of CSR and CSR disclosure. Based on the conceptual framework, the research exposes the drivers of CSR reporting as well as debates prior research on CSR disclosure and its consequences. Furthermore, a measurement method of CSP proposed built on CSR disclosure index in this paper. It devotes to enrich the corporate social responsibility reporting literature, offers implications for practice as well as outlines promising avenues for future research, especially in the differences of CSR disclosure among different countries.
How Does a Value-Added Model Compare to the Colorado Growth Model?

This working paper compares teacher evaluation scores from a typical value-added model with results from the Colorado Growth Model (CGM) and finds that use of the CGM in place of a value-added model depresses the evaluation scores for teachers with more English language learner students and increases the evaluation scores for teachers of low-achieving students.