Miracle-dz/UniFAR-FTUs huggingface dataset:
A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) is a prevalent form of cancer that develops from the epithelium of the oral cavity. OSCC is on the rise worldwide, and death rates associated with the disease are particularly high. Despite progress in understanding the mutational and expression landscape associated with OSCC, advances in deciphering these alterations for the development of therapeutic strategies have been limited. Further insight into the molecular cues that contribute to OSCC is therefore required. Here, we show that the transcriptional regulators YAP (YAP1) and TAZ (WWTR1), which are key effectors of the Hippo pathway, drive protumorigenic signals in OSCC. Regions of premalignant oral tissues exhibit aberrant nuclear YAP accumulation, suggesting that dysregulated YAP activity contributes to the onset of OSCC. Supporting this premise, we determined that nuclear YAP and TAZ activity drives OSCC cell proliferation, survival, and migration in vitro, and is required for OSCC tumor growth and metastasis in vivo. Global gene expression profiles associated with YAP and TAZ knockdown revealed changes in the control of gene expression implicated in protumorigenic signaling, including those required for cell cycle progression and survival. Notably, the transcriptional signature regulated by YAP and TAZ significantly correlates with gene expression changes occurring in human OSCCs identified by The Cancer Genome Atlas (TCGA), emphasizing a central role for YAP and TAZ in OSCC biology. Implications: This study defines a YAP/TAZ-regulated transcriptional program in OSCC and reveals novel roles for nuclear YAP/TAZ activity in the onset and progression of this cancer. Mol Cancer Res; 13(6); 957–68. ©2015 AACR.
A User-Centred Framework for Website Evaluation

The growth of the Internet has encouraged the creation of visually rich and perceptual interfaces on personal computers and mobile devices. Organisations develop websites for various purposes, and over time, the features and functions of websites have evolved significantly. Since website quality affects organisational performance, it is important to be able to assess the efficacy of websites. However, there are two key issues with the literature on website evaluation: a) a focus on specific aspects of website performance, not their overall impact, and b) limited attention on their ability to meet the broader needs of users, beyond usability and functionality, such as their social and emotional concerns. This paper uses design science to develop a theoreticallygrounded evaluation framework for this purpose. Drawing on Shneiderman (1998) and Brown (1999), the framework proposes that website evaluation should triangulate information from two sources (users and experts) and using different methods (task analysis with users, in-depth interview with users and expert reviews). The framework is applied in a website development project, and the results are discussed.
Enhanced recovery after surgery for hip and knee arthroplasty: a systematic review and meta-analysis

Objectives To collect data of randomised controlled trials (RCTs) and clinical controlled trials (CCTs) for evaluating the effects of enhanced recovery after surgery on postoperative recovery of patients who received total hip arthroplasty (THA) or total knee arthroplasty (TKA). Methods Relevant, published studies were identified using the following key words: arthroplasty, joint replacement, enhanced recovery after surgery, fast track surgery, multi-mode analgesia, diet management, or steroid hormones. The following databases were used to identify the literature consisting of RCTs or CCTs with a date of search of 31 December 2016: PubMed, Cochrane, Web of knowledge, Ovid SpringerLink and EMBASE. All relevant data were collected from studies meeting the inclusion criteria. The outcome variables were postoperative length of stay (LOS), 30-day readmission rate, and total incidence of complications. RevMan5.2. software was adopted for the meta-analysis. Results A total of 10 published studies (9936 cases) met the inclusion criteria. The cumulative data included 4205 cases receiving enhanced recovery after surgery (ERAS), and 5731 cases receiving traditional recovery after surgery (non-ERAS). The meta-analysis showed that LOS was significantly lower in the ERAS group than in the control group (non-ERAS group) (p<0.01), and there were fewer incidences of complications in the ERAS group than in the control group (p=0.03). However, no significant difference was found in the 30-day readmission rate (p=0.18). Conclusions ERAS significantly reduces LOS and incidence of complications in patients who have had THA or TKA. However, ERAS does not appear to significantly impact 30-day readmission rates.
High performance multi-camera tracking using shapes-from-silhouettes and occlusion removal

Reliable indoor tracking of objects and persons is still a major challenge in computer vision. As GPS is unavailable indoors, other methods have to be used. Multi-camera systems using colour cameras is one approach to tackle this problem. In this paper we will present a method based on shapes-from-silhouettes where the foreground/background segmentation videos are produced with state of the art methods. We will show that our tracker outperforms all the other trackers we evaluated and obtains an accuracy of 97.89% within 50 cm from the ground truth position on the proposed dataset.
Direct selection for mutations affecting specific splice sites in a hamster dihydrofolate reductase minigene

A Chinese hamster cell line containing an extra exon 2 (50 bp) inserted into a single intron of a dihydrofolate reductase (dhfr) minigene was constructed. The extra exon 2 was efficiently spliced into the RNA, resulting in an mRNA that is incapable of coding for the DHFR enzyme. Mutations that decreased splicing of this extra exon 2 caused it to be skipped and so produced normal dhfr mRNA. In contrast to the parental cell line, the splicing mutants display a DHFR-positive growth phenotype. Splicing mutants were isolated from this cell line after treatment with four different mutagens (racemic benzo[c]phenanthrene diol epoxide, ethyl methanesulfonate, ethyl nitrosourea, and UV irradiation). By polymerase chain reaction amplification and direct DNA sequencing, we determined the base changes in 66 mutants. Each of the mutagens generated highly specific base changes. All mutations were single-base substitutions and comprised 24 different changes distributed over 16 positions. Most of the mutations were within the consensus sequences at the exon 2 splice donor, acceptor, and branch sites. The RNA splicing patterns in the mutants were analyzed by quantitative reverse transcription-polymerase chain reaction. The recruitment of cryptic sites was rarely seen; simple exon skipping was the predominant mutant phenotype. The wide variety of mutations that produced exon skipping suggests that this phenotype is the typical consequence of splice site damage and supports the exon definition model of splice site selection. A few mutations were located outside the consensus sequences, in the exon or between the branch point and the polypyrimidine tract, identifying additional positions that play a role in splice site definition. That most of these 66 mutations fell within consensus sequences in this near-saturation mutagenesis suggests that splicing signals beyond the consensus may consist of robust RNA structures.
A parallel LSI architecture for LDPC decoder improving message-passing schedule

This paper proposes a parallel LSI architecture for LDPC decoder which improves a message-passing schedule. The proposed LDPC decoder is characterized as follows: (i) the column operations follow the row operations in a pipelined architecture to ensure that the row and column operations are performed concurrently; and (ii) the proposed parallel pipelined bit functional unit enables the decoder to perform every column operation using the messages which is updated by the row operations. These column operations can be performed without extending the single iterative decoding delay. Hardware implementation and simulation results show that the proposed decoder improves the decoding throughput and bit error performance with a small hardware overhead
[Clinical effectiveness of electroacupuncture therapy in combination with invasive therapy for massive liver cancer].

OBJECTIVE To investigate the clinical effectiveness of electroacupuncture therapy (EAT) in combination with liver artery intubation chemotherapy for massive liver cancer. METHODS A total of 106 patients were divided into 3 groups. In group A, patients underwent EAT in combination with invasive therapy. In group B, patients received EAT alone. In group C, patients underwent invasive therapy of liver artery intubation chemotherapy. In groups A and B, subcostal oblique incision was performed to expose liver cancer, and electrodes were inserted into the tumor under direct vision. In group A, liver artery intubation was performed during operation. After operation, chemotherapy was given from the tube. Liver artery intubation chemotherapy was performed only in group C. RESULTS The effective rate was 73.7% (28/38), 55.6% (20/36) and 28.1% (9/32) in groups A, B and C, respectively. CONCLUSIONS The effect of electro acupuncture therapy in combination with liver artery intubation chemotherapy achieves the best results. Therefore, it is an effective therapy for massive liver cancer.
DTNBP1, NRG1, DAOA, DAO and GRM3 Polymorphisms and Schizophrenia: An Association Study

Background: Several studies of the dystrobrevin-binding protein 1 gene (DTNBP1), neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), DAO activator (DAOA, G72), and metabotropic glutamate receptor 3 (GRM3) genes have suggested an association between variants of these genes and schizophrenia. Methods: In a replication attempt, single-nucleotide polymorphisms of the DTNBP1, NRG1, DAO, DAOA, and GRM3 genes were analyzed in three independent Scandinavian schizophrenia case-control samples. Results: One DTNBP1 and three GRM3 single-nucleotide polymorphisms showed nominal significant associations to the disease. However, after correction for multiple testing, there were no statistically significant allele, genotype or haplotype case-control differences. Conclusions: The present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia. Additional studies and meta-analyses are warranted to shed further light on these relationships.
Multilevel modelling of the prevalence of hospitalized patients infected with Pseudomonas aeruginosa

SUMMARY Pseudomonas aeruginosa is one of the leading nosocomial pathogens. The question of the respective contribution of endogenous and exogenous sources remains controversial. In this study, we shed new light on this issue by means of a multilevel logistic regression analysis which allowed a simultaneous investigation of factors associated with prevalence of patients infected with P. aeruginosa at two levels: patient and healthcare facility (HCF) in the eastern regions of France. A total of 25 533 in-patients from 51 HCFs were included in the analysis. The overall prevalence was 0·37% (range 0–1·65%). Multilevel modelling estimated that <14% of total variability of the outcome variable was explained by differences between HCFs and that after adjusting for patient-level variables, which explained 52% of HCF-level variance, the latter became non-significantly different from zero. A compositional effect (patient factors), rather than a contextual effect (ecological factors), explains heterogeneity of the prevalence of patients infected with P. aeruginosa in the eastern HCFs of France.
Numerical distance effect in the N240 component in a number-matching task

The event-related potential technique was used to investigate the time course and scalp-potential topography for the numerical distance effect in a number-matching task. Twenty undergraduates judged whether a number matched or did not match another number presented 1.5 s earlier. Compared with number pairs with a ‘small’ numerical distance (distance=1), number pairs with a ‘large’ numerical distance (greater than 2) showed a longer latency and a greater positive amplitude in the N240 component. This numerical distance effect was limited to fronto-central electrodes. These results were discussed in terms of the neural bases of the numerical distance effect during the automatic processing of numbers.
Rab 27 a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4 , 5-bisphosphate

The Rockefeller University Press $30.00 J. Cell Biol. www.jcb. org/cgi/doi/10.1083/jcb.201409082 Cite by DOI: 10.1083/jcb.201409082 JCB 1 of 18 *P.P. Gerber and M. Cabrini contributed equally to this paper. Correspondence to Matías Ostrowski: maostro@fmed.uba. ar Abbreviations used in this paper: CMV, cytomegalovirus; Ct, cycle threshold; DIC, differential interference contrast; fps, frames per second; GM-CSF, granulocyte–macrophage colony-stimulating factor; GS, Griscelli syndrome; LRO, lysosome-related organelle; LSCM, laser-scanning confocal microscopy; MDM, monocyte-derived macrophage; MVEs, multivesicular endosomes; PBMC, peripheral blood mononuclear cell; PE, phycoerythrin; PH, pleckstrin homology; p.i. , postinfection; PI(4,5)P2, phosphatidylinositol 4,5-bisphosphate; PI(4)P, phosphatidylinositol 4-phosphate; PM, plasma membrane; qPCR, quantitative RT-PCR; TEMs, tetraspanin-enriched microdomains; TLC, thin layer chromatography; VCCs, virus-containing compartments. Introduction
POWER7: IBM's next generation server processor

Power Systems™ continue strong 7th Generation Power chip: Balanced Multi-Core design EDRAM technology SMT4 Greater then 4X performance in same power envelope as previous generation. Scales to 32 socket, 1024 threads balanced system. Building block for peta-scale PERCS project POWER7 Systems Running in Lab AIX®, IBM i, Linux® all operational.
A Phase II Study of Doxorubicin, Cisplatin, and 5-Fluorouracil in Patients with Advanced Adenocarcinoma of the Stomach or Esophagus

Background: The combination of epirubicin, cisplatin, and infusional 5-fluorouracil (ECF) currently represents a standard and effective regimen for the treatment of advanced gastroesophageal cancer. The use of doxorubicin as an alternative to epirubicin in the ECF regimen has not been evaluated. Methods: Thirty-two patients with metastatic adenocarcinoma of the stomach, gastroesophageal junction, or esophagus were treated with cisplatin 60 mg/m2 and doxorubicin 30 mg/m2 repeated every 21 days, in combination with infusional 5-fluorouracil 200 mg/m2/day (ACF). Results: Major objective responses were observed in 28 percent of patients (46 percent previously untreated; 13 percent previously treated), with one complete response. The median progression-free survival was 4.0 months, and the median overall survival was 5.8 months (9.3 months previously untreated; 4.5 months previously treated). The major (Grade 3–4) toxicities were neutropenia (34 percent), anorexia (31 percent), nausea (28 percent), diarrhea (19 percent), and stomatitis (16 percent). Conclusion: In comparison with historical data taken from published trials of ECF, the ACF regimen appears similar in efficacy when differences in prior treatment status are taken into account. However, ACF appears to be associated with a higher incidence of major toxicities. Our findings therefore support the continued use of epirubicin rather than doxorubicin in combination chemotherapy regimens for advanced gastroesophageal cancer.
Q‐TWiST analysis of ixabepilone in combination with capecitabine on quality of life in patients with metastatic breast cancer

Combination therapy with ixabepilone and capecitabine (cape) is approved for use in patients with locally advanced/metastatic breast cancer that is resistant to treatment with anthracyclines or taxanes. The current study evaluated the trade‐off between quality and quantity of life using quality‐adjusted time without symptoms or toxicity (Q‐TWiST) outcomes.
Underlying Processes of an Inverted Personalization Effect in Multimedia Learning – An Eye-Tracking Study

One of the frequently examined design principles in multimedia learning is the personalization principle. Based on empirical evidence this principle states that using personalized messages in multimedia learning is more beneficial than using formal language (e.g., using ‘you’ instead of ‘the’). Although there is evidence that these slight changes in regard to the language style affect learning, motivation and the perceived cognitive load, it remains unclear, (1) whether the positive effects of personalized language can be transferred to all kinds of content of learning materials (e.g., specific potentially aversive health issues) and (2) which are the underlying processes (e.g., attention allocation) of the personalization effect. German university students (N = 37) learned symptoms and causes of cerebral hemorrhages either with a formal or a personalized version of the learning material. Analysis revealed comparable results to the few existing previous studies, indicating an inverted personalization effect for potentially aversive learning material. This effect was specifically revealed in regard to decreased average fixation duration and the number of fixations exclusively on the images in the personalized compared to the formal version. These results can be seen as indicators for an inverted effect of personalization on the level of visual attention.
Demand for and Regulation of Cardiac Services

Efforts to regionalize cardiac services can increase access costs for patients. This study quantifies this trade off by estimating the effects of changes in the regulation of hospital services on treatments and outcomes. A demand model for surgery services is specified in which heart attack victims form expectations of the need for and productivity of surgery in their choice of hospital and treatment. The results indicate that mortality is relatively insensitive to moderate changes in policy: changes in travel costs and volume offset one another. Despite similar health outcomes, the competing policies have different implications for taxpayers.
Diagnostic Profiles and Prescribing Patterns in Everyday Anthroposophic Medical Practice – a Prospective Multi-Centre Study

Background: Although anthroposophic medicine has been used for more than 80 years and global interest in complementary treatments is increasing, a comprehensive and long-term description of everyday anthroposophic care is still lacking. Our study aims to evaluate how anthroposophic medicine is practised under everyday conditions. Methods: A total of 38 primary-care physicians in Germany participated in this prospective, multi-centre observational study. Prescriptions, diagnoses, and non-pharmacological therapies were reported for each consecutive patient. Results: In 2005, 95,116 prescriptions for 32,839 patients (56.2% children, 57.3% female) were recorded. The median duration of consultation depended on physician specialization (general practitioners: 9.5 min; paediatricians: 8.1 min). The most frequent single diagnoses were acute upper respiratory tract infections (URTI), otitis media, and bronchitis in children; hypertension, breast cancer, and depressive episodes in adult females; and hypertension, URTI, and asthma in adult males. Anthroposophic remedies accounted for 41.8% of all drugs prescribed. The odds ratio (OR) for receiving an anthroposophic remedy was very high for cancer (OR = 4.5; 95% CI: 4.2–4.8) and >1 for dorsopathies (OR = 1.5; CI: 1.3–1.6), otitis media (OR = 1.3; CI: 1.2–1.3), and URTI (OR = 1.1; CI: 1.1–1.2). Of the 5,289 therapeutic procedures prescribed, 27% were anthroposophic. Conclusion: A broad range of anthroposophic remedies and non-pharmacological therapies are prescribed for a specific set of diseases in everyday anthroposophic practice. Particularly, patients <60 years received anthroposophic care. Our findings will help in the planning and implementation of further studies.
Compassion, empathy and sympathy expression features in affective robotics

The present paper identifies differences in the expression features of compassion, sympathy and empathy in British English and Polish that need to be tuned accordingly in socially interactive robots to enable them to operate successfully in these cultures. The results showed that English compassion is characterised by more positive valence and more of a desire to act than Polish współczucie. Polish empatia is also characterised by a more negative valence than English empathy, which has a wider range of application. When used in positive contexts, English sympathy corresponds to Polish sympatia; however, it also acquires elements of negative valence in English. The results further showed that although the processes of emotion recognition and expression in robotics must be tuned to culture-specific emotion models, the more explicit patterns of responsiveness (British English for the compassion model in our case) is also recommended for the transfer to make the cognitive and sensory infocommunication more readily interpretable by the interacting agents.
COMBAT ID - COMBAT IDENTIFICATION SYSTEM

Abstract : This paper will document the development of the Combat Identification (CombatID) System. The CombatID System was designed to create a platform agnostic payload that could be attached to any fielded Unmanned Ground Vehicle (UGV) to assist the Soldier in contingency basing operations. This paper will describe the approach taken to develop the system and provide a detailed description of the system, including sample results for individual modules. This paper will also provide insight on the evaluation of CombatID system's performance.
A Radiation Hardened Linear Macrocell Array

This paper describes the development and combination of monolithic radiation hardened linear macrocells. These are used as replacements for hybridized bipolar SSI (Small Scale Integration) linear microcircuits, discrete semiconductors and passive devices, at low technical, schedule and cost risk. The silicon technology used in the fabrication of such circuits is conventional; however, the approach develops achievable next generation design and fabrication techniques for producing radiation hardened linear microcircuits at reduced cost with high reliability. The paper discusses the selected technology, process, design approach, testability and testing implications, improvements in yield and reliability and the post radiation performance obtained by the semicustom macrocell approach at the device and cell level
Fence-like Quasi-periodic Texture Detection in Images

The focus of this article is on automatic detection of fence or wire mesh (a form of quasi-periodic texture) inimages through frequency domain analysis. Textures can be broadly classified in to two general classes: quasiperiodicand random. For example, a fence has a repetitive geometric pattern, which can be classified as a quasiperiodictexture. Quasi-periodic textures can be easily detected in the frequency spectrum of an image as they resultin peaks in the frequency spectrum. This article explores a novel way of de-fencing viewed as a quasi-periodic texturesegmentation by filtering in frequency domain to segregate the fence from the background. A resulting de-fencedimage is followed by support vector machine classification. An interesting application of the proposed approach isthe removal of occluding structures such as fence or wire mesh in animal enclosure photography.