Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of the effectiveness of golimumab 50-mg and 100-mg regimens in patients with rheumatoid arthritis in daily practice

Abstract Objectives. To assess the effectiveness of the golimumab (GLM) 50-mg and 100-mg regimens in patients with rheumatoid arthritis (RA) in daily practice. Methods. We retrospectively analyzed RA patients who started GLM between September 2011 and July 2012. Patients were divided into three groups: a 50-mg group; a 50/100-mg group (had a dose increase to 100 mg); and a 100-mg group (started GLM at 100 mg). We assessed Disease Activity Score 28 (DAS28) and treatment continuation rate. Risk factors associated with time to discontinuation of the 50-mg regimen were determined with proportional hazards analysis. Results. We analyzed 74 patients: 43 in the 50-mg group, 23 in the 50/100-mg group, and 8 in the 100-mg group. DAS28 improved from 4.0 ± 1.0, 4.8 ± 1.0, and 4.7 ± 1.9, respectively, at baseline to 2.4 ± 1.2, 3.3 ± 1.5, and 2.5 ± 0.7, respectively, at week 52. Treatment continuation rates at week 52 were 73.7%, 60.9%, and 87.5%, respectively. In the 50/100-mg group, the mean DAS28 improved significantly from 4.4 ± 1.2 before to 3.6 ± 1.3 12 weeks after the dose increase. Oral corticosteroid therapy ≥ 5 mg/day, previous use of two biologic agents, and DAS28 > 5.1 at initiation of GLM were significantly associated with discontinuation of the 50-mg regimen. Conclusions. Both GLM 50-mg and 100-mg regimens are effective in patients with RA in daily practice.
Reproductive survival of mammalian cells after irradiation at ultra-high dose-rates: further observations and their importance for radiotherapy.

Abstract Somewhat conflicting data from earlier experiments by ourselves and others suggested that under certain conditions, survival curves for the reproductive capacity of mammalian cells irradiated at ultra-high dose-rates (nanosecond-to-microsecond pulses) with X rays or high-energy electrons exhibited an inflected “hockey-stick” shape. Other workers failed to observe such “hockey-stick” survival curves when using apparently similar radiation conditions. Using a 400 keV electron beam with a pulse duration of about 3 ns, dense monolayers of HeLa cells were irradiated attached to plastic Petri dishes, or dense monolayers of P.388 murine ascites leukaemia cells were irradiated suspended on membrane filters. The cells were either aerobic, hypoxic, or in a 0·35 per cent oxygen/nitrogen atmosphere at the time of irradiation. Survival of HeLa cells was assessed by the ability to form macroscopic clones in vitro; survival of P.388 leukaemia cells was assessed in vivo by tumour “takes” from serial dilutions of.
Survey on the Narrative Structure of the Interactive Storytelling Authoring System

Storytelling is a technology that enables people to tell their story, and its importance becomes more and more in the movie, marketing, game, education and literature fields. Digital Storytelling is advanced from the traditional storytelling in the digital age and is a technology that uses a digital technology as media or means of expression. As one of the fields of the digital storytelling, an interactive storytelling enables a multi-stories to be created according to the user's interaction, and the narrative structure is used for them. In this paper, we examine various technologies for a narrative structure that an interactive storytelling system uses.
Service quality in P 2 P streaming systems

Relying on end users to contribute bandwidth to the system peerto-peer (P2P) overlays provide a cheap and scalable way to distribute live video content in the Internet. However, being inherently dynamic due to peers joining and leaving the system at arbitrary time and running over the best-effort Internet successful commercial usage of these systems may suffer from unstable media quality provided to end users. In this survey we consider problems related to providing quality of media delivery in P2P streaming systems. We show that in spite of numerous systems available today no one incorporates mechanisms capable to maintain a certain level of quality of delivered media. We identify reasons behind that and discuss possible solutions to this problem.
Brief reportNovel approach to the application of botulinum toxin to the flexor digitorum superficialis muscle in acquired brain injury

Primary objective: To determine if the finger flexor mapping technique is useful in the reduction of spasticity when injecting neurotoxin within the flexor digitorum superficialis muscle. Research design: Case series of consecutive persons with acquired brain injury with upper limb spasticity. Methods and procedures: The flexor digitorum superficialis mapping technique was used to determine the optimal location for botulinum toxin A insertion into each belly of the flexor digitorum superficialis. Modified Ashworth Scale (MAS) ratings were recorded pre- and post-flexor digitorum superficialis injection from 17 patients (18 limbs) with upper limb spasticity. Main outcomes and results: The pre-injection mean MAS score was 3.0 ± 0.7 and the post-injection mean MAS score was 1.5 ± 0.9 for this cohort. Using the Wilcoxon matched pairs signed rank test, the mean MAS finger flexor scores decreased significantly ( p < 0.05). No adverse events were noted with the procedure. Conclusions: This novel technique appears to be feasible and effective for placement of botulinum toxin in the treatment of finger flexor spasticity. Further studies are warranted to compare this method of administration with other injection approaches for the treatment of finger flexor spasticity.
HDL structure and function is profoundly affected when stored frozen in the absence of cryoprotectants[S]

Analysis of structural and functional parameters of HDL has gained significant momentum in recent years because they are stronger predictors of cardiovascular risk than HDL-cholesterol levels. Surprisingly, in most HDL studies, very low attention is paid to HDL storage, which might critically affect functional properties. In the present study, we systematically examined the impact of storage and freezing on the structural/functional properties of freshly isolated HDL. Initial damage to HDL starts between week 1 and week 4 of storage. We observed that prolonged freezing at −20°C or −70°C led to a shedding of apoA-I from HDL and to the formation of large protein-poor particles, indicating that HDL is irreversibly disrupted. These structural alterations profoundly affected key metrics of HDL function, including HDL-cholesterol efflux capacity and HDL paraoxonase activity. Flash-freezing of isolated HDL prior to storage at −70°C did not preserve HDL structure. However, addition of the cryoprotectants, sucrose or glycerol, completely preserved structure and function of HDL when stored for at least 2 years. Our data clearly indicate that HDL is a complex particle requiring special attention when stored. Addition of cryoprotectants to isolated HDL samples before storage will make biochemical and clinical HDL research studies more reproducible and comparable.
erum Carotenoid and Tocopherol Concentrations ary by Dietary Pattern among African Americans

p t e a BSTRACT ackground Intakes and biochemical concentrations of arotenoids and tocopherols have been associated with hronic diseases. bjective To describe dietary patterns in Jackson Heart tudy participants and to determine if biochemical meaurements of antioxidants differ across these. esign Cross-sectional analysis of data for 373 Africanmerican men and women (age 35 to 80 years), particiating in the Diet and Physical Activity Substudy of the ackson Heart Study. ethods Dietary intake was assessed with a region specific ood frequency questionnaire. Patterns were defined by luster analysis of food groups, as percent of energy intake. esults Four dietary patterns were identified: fast food, outhern, prudent, and juice. Individuals in the fast-food attern (n 153) had significantly lower serum concentraions of lutein plus zeaxanthin and -cryptoxanthin; hose in the Southern cluster (n 99) had significantly ower serum -carotene; and those in the prudent (n 63) nd juice (n 58) clusters had significantly higher serum -carotene and -cryptoxanthin (P 0.05) relative to hose in at least one other cluster (all P 0.05). The juice
Constructing Energy Aware Home Automation within the IPv6-USN Architecture

The Internet of Things idea and the rapid expansion of IPv6, moreover after IETF defined 6LoWPAN as a technique to apply IPv6 into IEEE 802.15. 4 low-power wireless network standard is added potential of the USN connected to Internet and it made up IPv6-USN as the new architecture. However, if we implement IPv6-USN to home automation, the energy consumption of IPv6-USN node operation is bounded. There is the need to periodically replacing its batteries because it commonly used AA batteries as power source, but the complexity of home building characteristics make it is not easy. In this paper, we present our study to develop energy aware home automation in IPv6-USN infrastructure. Our goal is to develop a system that is robust which aware with energy consumption. We designed the home automation nodes with smart and energy efficient oriented RPL routing. By having efficient control transmission and optimal objective function, we can maintain operation performance level of our IPv6-USN home automation with energy consumption reduction around 20%, average latency about 1.0875s, and packet delivery rate above 88.875%.
Adaptation of Bees Algorithm for QOS-based Selection and Replacement of Web Services

Web service is a new paradigm of internet software and distributed computing. With the growth of web services number, the capability to find the optimal service which can substitute the fault service from different communities represents a very hard operation. The researched service must have the same functionalities of the fault service and the highest quality of service scale. In this paper, we propose heuristic method based on Bees Algorithm to find the optimal service which can substitute the fault service. In our approach, we design a distributed environment based on Peer-to-Peer architecture in order to present distributed communities which are considered as flowers and research requests as bees.
Study of User's Adoption Behavior for Innovative Mobile Commerce - Take the Internet Chauffeured Car as an Example

Internet chauffeured car (abbreviated as ICC) is a typical representative of the innovative mobile commerce and has gained rapidly development in a short period. But research about its users’ adoption behavior is not reach. The changing market environment also makes it important for ICC platforms timely grasp their users’ adoption behavior characteristics. Our study is based on the user’s view. By introducing UTAUT and structural equation model (SEM), factors affecting the user’s adoption behavior and their influencing path are empirically analyzed. Results show that expected performance, trust tendency and initial trust all have positive effect on the user’s adoption behavior significantly. Convenient condition positively influences adoption behavior by initial trust as a mediator. But perceived risk’s expected negative influence on adoption behavior is not significant. The results can provide some reference for platforms to promote their service and make related management policies
AAA Authorization Application Examples

This memo describes several examples of applications requiring authorization. Each application is described in terms of a consistent framework, and specific authorization requirements of each application are given. This material was not contributed by the working groups responsible for the applications and should not be considered prescriptive for how the applications will meet their authorization needs. Rather the intent is to explore the fundamental needs of a variety of different applications with the view of compiling a set of requirements that an authorization protocol will need to meet in order to be generally useful.
Partial purification and characterization of the novel halotolerant and alkalophilic laccase produced by a new isolate of Bacillus subtilis LP2

Abstract Laccases (benzenediol: oxygen oxidoreductases, [EC1.10.3.2] are mostly known as members of the blue multicopper oxidase family that are used in very different industrial applications: textile, pulp and paper, food, cosmetics industries, bioremediation process, biosensor, biofuel and organic synthesis. Stability against the extreme conditions is an important property and it makes laccase suitable for several industrial processes. Laccase should have salt resistance to be used in textile dye degradation because the textile wastewaters include dyes with high concentrations of salts, especially NaCl. Bacterial laccases are preferable to be used for bioremediation process due to their high stability to extremely salt contaminated and alkalophilic environment. Bacillus subtilis LP2 was identified as a source of alkali-tolerant, salt resistant laccase. Laccase showed activity over a wide pH (4–10) and temperature (30–80 °C) range. Maximum laccase activity was observed as 140.4 U/mg (umol/min*mg) at pH 8 and 50 °C with the substrate guaiacol. Stability of laccase was determined as 60% and 20% after incubation of the enzyme for different time intervals of 20 and 40 min at 50 °C and pH 8. SDS (10 mM) and EDTA (5 mM) decreased laccase activity from 100% to 0% and 56%, respectively. Despite the other inhibitors, NaCI increased the activity of laccase to 167% at 500 mM concentration. Laccase from Bacillus subtilis LP2 barely showed the activity on the substrates vanillin and L-tyrosine. These results clearly show that laccase from Bacillus subtilis LP2 has high potential to be used for several applications in textile industry.
Characterization of Fusarium oxysporum isolates from common bean and sugar beet using pathogenicity assays and random-amplified polymorphic DNA markers

Fusarium wilt is an economically important fungal disease of common bean and sugar beet in the Central High Plains (CHP) region of the USA, with yield losses approaching 30% under appropriate environmental conditions. The objective of this study was to characterize genetic diversity and pathogenicity of isolates of Fusarium oxysporum obtained from common bean and sugar beet plants in the CHP that exhibited Fusarium wilt symptoms. A total of 166 isolates of F. oxysporum isolated from diseased common bean plants were screened for pathogenicity on the universal susceptible common bean cultivar ‘UI 114’. Only four of 166 isolates were pathogenic and were designated F. oxysporum f.sp. phaseoli (Fop). A set of 34 isolates, including pathogenic Fop, F. oxysporum f.sp. betae (Fob) isolates pathogenic on sugar beet, and non-pathogenic (Fo) isolates, were selected for random-amplified polymorphic DNA (RAPD) analysis. A total of 12 RAPD primers, which generated 105 polymorphic bands, were used to construct an unweighted paired group method with arithmetic averages dendrogram based on Jaccard's coefficient of similarity. All CHP Fop isolates had identical RAPD banding patterns, suggesting low genetic diversity for Fop in this region. CHP Fob isolates showed a greater degree of diversity, but in general clustered together in a grouping distinct from Fop isolates. As RAPD markers revealed such a high level of genetic diversity across all isolates examined, we conclude that RAPD markers had only limited usefulness in correlating pathogenicity among the isolates and races in this study.
The extracorporeal septum plasty: a technique to correct difficult nasal deformities.

The severely deformed septum remains a problem. We recommend removing the whole septum and reconstructing a new, straight, septum plane that will be replanted (i.e., extracorporeal correction). Until April 1993 we had used this technique in 1012 patients with functionally as well as aesthetically encouraging results. All septal replants healed primarily. A problem may occur with this technique in reconstructing the dorsum and in stabilizing the replant. The exact technique is explained in detail, and the results are compared with those reported in the literature. Even with this radical procedure, the rate of complication was only 2.2 percent. Biopsies provided the histologic proof of cartilage survival.
A density based algorithm for community detection in hyper-networks

We propose an efficient community detection algorithm for networks that comprise more than one entities, such as users, tags and items, with ternary or higher relations between them. Such networks are also known as multi-partite and can be used for representing social tagging systems but also the activity in streaming media. Detecting communities in multi-paritite networks entails different challenges than in simple networks. The proposed algorithm is able to detect crisp or overlapping communities, and is applied on four data sets from social tagging systems and Twitter, and is compared with other multi-partite community detection algorithms.
Is (President, 大統領) a Correct Sense Pair? - Linking and Creating Bilingual Sense Correspondences

This paper presents a method of linking and creating bilingual sense correspondences between English and Japanese noun word dictionaries. Locally, we extracted bilingual noun words using sentence-based similarity. Globally, for each monolingual dictionary, we identified domain-specific senses using a textual corpus with category information. We incorporated these, i.e., we assigned a sense to each noun word of the extracted bilingual words keeping domain (category) consistency. Evaluation on the WordNet 3.0 and EDR Japanese dictionaries using Reuters and Mainichi Japanese newspaper corpora showed 23.1% improvement of bilingual noun word extraction over the baseline with local data view only. Moreover, we found that the extracted bilingual noun senses can be used as a lexical resource for the machine translation.
Culprit-only or multivessel PCI in cardiogenic shock myocardial infarction patients: simpler solutions are more likely to be correct than complex ones.

Despite all the advances in acute myocardial infarction (AMI) treatment, cardiogenic shock (CS) is still the leading cause of mortality among AMI patients admitted to the hospital (1). Most of the deaths occur within the first 30 days, about half within the first 48 hours (2,3). Although total mortality has decreased, recent trends point to an increase in hospital mortality (4).
Konsep Pembelajaran PAI bagi Anak Berkebutuhan Khusus di Sekolah Inklusi: Studi Kasus di SD Semai Jepara

Education plays a very pivotal role for human beings in achieving social welfare, without any discrimination, including children with special needs. The existence of inclusive schools becomes a solution in fulfilling special needs children’s right to education. It is due to the fact that they can learn and socialize with physically and mentally healthy children in inclusive schools. This present study aims to explore the learning concept of Islamic education applied for teaching children with special needs at SD Semai Jepara, one of inclusive schools in Central Java-Indonesia. A qualitative descriptive approach was designed in this research. The findings promote that the implementation of Islamic education at SD Semai Jepara was similar to the one in regular schools. It indicates that the materials taught to the students were just the same. Nonetheless, the teaching methods used in delivering the materials were different. One of the teaching methods employed in teaching Islamic education for the special needs children was parody. Additionally, in certain materials, the children were divided into two learning groups, namely: large and small ones, to enhance the teaching and learning processes. This study also exposes that the teachers are supposed to be as creative as possible in creating appropriate learning atmosphere in teaching Islamic education since there are lots of students with the variety of backgrounds who possess special needs.
Effect of load position on physiological and perceptual responses during load carriage with an internal frame backpack

The purpose of this study was to determine the effect of load position in an internal frame backpack on physiological and perceptual variables. Ten female participants walked on a level treadmill for 10 min carrying 25% of their body weight in a high, central, or low position. The variables measured included oxygen consumption (VO2), heart rate (HR), respiratory exchange ratio (R), respiratory rate (RR), minute ventilation (VE), and rating of perceived exertion (RPE). VO2, VE, and RPE were significantly lower in the high position (18.6 ± 2.3 ml/kg/min, 31.7 ± 5.0 l/min, 2.8 ± 0.8, respectively) compared to the low position (22.2 ± 3.0 ml/kg/min, 38.6 ± 7.5 l/min, 3.7 ± 1.0, respectively). HR, R, and RR did not change significantly as the load was moved from the high (129.8 ± 16.8, 0.89 ± 0.06, 30.3 ± 4.2, respectively) to the low position (136.0 ± 25.3, 0.92 ± 0.04, 33.8 ± 5.2, respectively). The results of this study suggest that load placement is an important factor in the physiological and perceptual responses to load carriage, and that packing heavy items high in the backpack may be the most energy efficient method of carrying a load on the back.
A quantitative assessment of DInSAR Time series accuracy in volcanic areas: From the first to second generation SAR sensors

We perform a quantitative assessment of the accuracy of Differential SAR Interferometry (DInSAR) time series in volcanic areas, retrieved through “first” and “second generation” SAR data. In particular, we analyze the impact that the wavelengths and looking geometries may have in the DInSAR measurement retrieval depending on the radar system. To this aim, we focus on the DInSAR algorithm referred to as Small BAseline Subset (SBAS) to generate mean deformation velocity maps and corresponding time series starting from sequences of SAR images. Moreover, we consider collections of SAR data acquired by the ERS-1/2 and ENVISAT (C-band), and COSMO-SkyMed (Xband) sensors over the volcanic area of the Campi Flegrei caldera, Southern Italy. We invert these SAR data sequences through the SBAS-DInSAR technique, thus obtaining C- and X- band deformation time series that we compare to continuous GPS measurements, the latter assumed as reference. The achieved results provide, in addition to a clear picture of the surface deformation phenomena already occurred and occurring in the selected case study, relevant indications for the analysis of the SBAS-DInSAR time series accuracies in volcanic areas passing from the first to second generation SAR sensors.
Bidding for Business: New Evidence on the Effect of Locally Offered Economic Development Incentives in a Metropolitan Area

The use of local economic development incentives within a metropolitan area has undergone less analysis than incentives that attempt to alter interregional business location decisions. This is unfortunate because other factors that influence where business resides are constant across cities in a metropolitan area, and a properly used incentive is more likely to alter a business location decision. To comment on these issues, the authors use a simultaneous equation model to conduct regression analyses of panel data from 112 cities in the Detroit metropolitan area. They find that only certain forms of local incentives, at certain times, exert the expected positive influence on the local value of commercial and manufacturing property. The findings are tied to issues related to the redistribution of economic activity from the core to the periphery in U.S. metropolitan areas, and the authors conclude with policy suggestions on the future use of local incentives.