Miracle-dz/UniFAR-FTUs huggingface dataset:
Tricuspid Dysplasia in Dogs

Abstract The aim of the study was to estimate prevalence of tricuspid dysplasia (TD) in dogs with respect to breed, age, sex, clinical signs, and echocardiographic findings and to compare this data with literature. TD was found in 15 dogs (6.5% of congenital cardiac disease) of 215 dogs with congenital heart defects. All dogs had right heart enlargement on thoracic radiographs, echocardiography, and electrocardiography. Doppler echocardiography revealed tricuspid valve regurgitation. Seven dogs presented no clinical symptoms to date. TD took the form of Ebstein anomaly in all Labrador Retrievers, one Boxer, and one German Shepherd dog. TD predominated in males (11 males vs. three females). The body weight of the affected dogs, with the exception of the Miniature Schnauzer, exceeded 20 kg. Two dogs (Boxer and Bull Terrier) had additional congenital cardiac lesions in the form of mitral valve dysplasia. The most affected breeds in the study were the Labrador Retriever and Boxer.
Psychiatric comorbidities in dystonia: Emerging concepts

Psychiatric disorders are highly prevalent in patients with dystonia and have a profound effect on quality of life. Patients with dystonia frequently meet criteria for anxiety disorders, especially social phobia, and major depressive disorder. Deficits in emotional processing have also been demonstrated in some dystonia populations. Onset of psychiatric disturbances in patients with dystonia often precedes onset of motor symptoms, suggesting that the pathophysiology of dystonia itself contributes to the genesis of psychiatric disturbances. This article examines the hypothesis that mood and anxiety disorders are intrinsic to the neurobiology of dystonia, citing the available literature, which is derived mostly from research on focal isolated dystonias. Limitations of studies are identified, and the role of emotional reactivity, especially in the context of pain secondary to dystonia, is recognized. Available evidence underscores the need to develop dystonia assessment tools that incorporate psychiatric measures. Such tools would allow for a better understanding of the full spectrum of dystonia presentations and facilitate research on the treatment of dystonia as well as the treatment of psychiatric illnesses in the context of dystonia. This article, solicited for a special Movement Disorders issue on novel research findings and emerging concepts in dystonia, addresses the following issues: (1) To what extent are psychiatric disturbances related to the pathophysiology of dystonia? (2) What is the impact of psychiatric disturbances on outcome measures of current assessment tools for dystonia? (3) How do psychiatric comorbidities influence the treatment of dystonia? Answers to these questions will lead to an increased appreciation of psychiatric disorders in dystonia, a better understanding of brain physiology, more nuanced research questions pertaining to this population, better clinical scales that can be used to further patient management and research, and improved patient outcomes. © 2013 Movement Disorder Society
A delay estimation method using reduced model of RLC interconnects

This paper proposes a new method for delay time calculation in RLC interconnects. This method is simple, yet precise. The proposed method can calculate the delay time of RLC interconnects by simple numerical formula calculation without complex moment calculation using reduced model RLC interconnects. The results using the proposed method for RLC circuits show that the average relative error is within 10% in comparison with HSPICE simulation results.
Year : 2006 Seed size variability : from carob to carats

The seeds of various plants were used as weights because their mass reputedly varies so little. Carob (Ceratonia siliqua), which has given its name to the carat, is particularly famous in this regard. But are carob seeds unusually constant in weight and, if not, how did the myth arise? The variability of seeds sampled from a collection of carob trees (CV=23%) was close to the average of 63 species reviewed from the literature (CV=25%). However, in a perception experiment observers could discriminate differences in carob seed weight of around 5% by eye demonstrating the potential for humans to greatly reduce natural variation. Interestingly, the variability of pre-metrication carat weight standards is also around 5% suggesting that human rather than natural selection gave rise to the carob myth. doi: 10.1098/rsbl.2006. 0476 , 397-400 2 2006 Biol. Lett. Lindsay A Turnbull, Luis Santamaria, Toni Martorell, Joan Rallo and Andy Hector Seed size variability: from carob to carats Supplementary data http://rsbl.royalsocietypublishing. org/content/suppl/2008/12/08/2.3. 397.DC1. html "Data Supplement"
Suicidal Ideation in Outpatients With Chronic Musculoskeletal Pain: An Exploratory Study of the Role of Sleep Onset Insomnia and Pain Intensity

ObjectivesSleep disturbance, depression, and heightened risk of suicide are among the most clinically significant sequelae of chronic pain. While sleep disturbance is associated with suicidality in patients with major depression and is a significant independent predictor of completed suicide in psychiatric patients, it is not known whether sleep disturbance is associated with suicidal behavior in chronic pain. This exploratory study evaluates the importance of insomnia in discriminating suicidal ideation in chronic pain relative to depression severity and other pain-related factors. MethodsFifty-one outpatients with non-cancer chronic pain were recruited. Subjects completed a pain and sleep survey, the Pittsburgh Sleep Quality Index, the Beck Depression Inventory, and the Multidimensional Pain Inventory. Subjects were classified as “suicidal ideators” or “non-ideators” based on their responses to BDI-Item 9 (Suicide). Bivariate analyses and multivariate discriminant function analyses were conducted. ResultsTwenty-four percent reported suicidal ideation (without intent). Suicidal ideators endorsed higher levels of: sleep onset insomnia, pain intensity, medication usage, pain-related interference, affective distress, and depressive symptoms (P < 0.03). These 6 variables were entered into stepwise discriminant function analyses. Two variables predicted group membership: Sleep Onset Insomnia Severity and Pain Intensity, respectively. The discriminant function correctly classified 84.3% of the cases (P < 0.0001). DiscussionChronic pain patients who self-reported severe and frequent initial insomnia with concomitant daytime dysfunction and high pain intensity were more likely to report passive suicidal ideation, independent from the effects of depression severity. Future research aimed at determining whether sleep disturbance is a modifiable risk factor for suicidal ideation in chronic pain is warranted.
Cervical Partial Hydatidiform Molar Pregnancy

Background: Cervical hydatidiform molar pregnancy is an exceedingly rare occurrence that has been reported only twice before. Case: We report a 25-year-old, G4P1D&C2 woman with a positive pregnancy test and vaginal bleeding. A cervical pregnancy with hydatidiform mole was detected on transvaginal ultrasound and color Doppler examinations. Magnetic resonance imaging was used to localize the lesion. Dilatation and curettage was performed and bleeding that was initially brisk ceased after bimanual pressure. Histopathological examination revealed a partial hydatidiform molar pregnancy. Serial β-hCG measurements showed a decline without need for adjuvant chemotherapy. Conclusion: Conservative fertility-sparing management was successful in this potentially fatal rare case.
Proteins from the prokaryotic nucleoid: primary and quaternary structure of the 15‐kD Escherichia coli DNA binding protein H‐NS

The primary sequence of H‐NS (136 amino acid residues, Mr = 15402), an abundant Escherichia coli DNA‐binding protein, has been elucidated and its quaternary structure has been investigated by protein‐protein cross‐linking reactions. It was found that H‐NS exists predominantly as a dimer, even at very low concentrations, but may form tetramers at higher concentrations and that the protein‐protein interaction responsible for the dimerization is chiefly hydrophobic.
Predictors of change in nutritional and hemoglobin status among adults treated for tuberculosis in Tanzania.

BACKGROUND Patients with tuberculosis (TB) often suffer from profound malnutrition. OBJECTIVE To examine the patterns and predictors of change in nutritional and hemoglobin status during and after TB treatment. METHODS A total of 471 human immunodeficiency virus (HIV) positive and 416 HIV-negative adults with pulmonary TB were prospectively followed in Dar es Salaam, Tanzania. All patients received 8 months' TB treatment following enrollment. RESULTS About 40% of HIV-positive and 47% of HIV-negative TB patients had body mass index (BMI) < 18.5 kg/m 2 at baseline, while about 94% of HIV-positive and 84% of HIV-negative participants were anemic at baseline. Both HIV-positive and HIV-negative patients experienced increases in BMI and hemoglobin concentrations over the course of TB treatment. Among HIV- positive patients, older age, low CD4 cell counts, and high viral load were independently associated with a smaller increase in BMI from baseline to 8 months. Fe- male sex, older age, low CD4 cell counts, previous TB infection and less money spent on food were independently associated with a smaller improvement in hemoglobin levels among HIV-positive patients during treatment. CONCLUSION HIV-positive TB patients, especially those with low CD4 cell counts, showed poor nutritional recovery during TB treatment. Adequate nutritional support should be considered during TB treatment.
A Fast Computation Method in Frequency Domain for Power Ground Plane Impedance Calculation Using the Mobius Transform

A new method to reduce the computation time in power/ground-plane analysis is proposed. The proposed method is based on an approximation of impedance in the frequency domain using Mobius transform. The power/ground plane impedance is transformed by Mobius transform and is more linear than the raw impedance, which ensures that a simple approximation is possible. After the approximation, an inverse Mobius transform is applied to predict the power/ground plane impedance. This method displays the high speed of computing with good accuracy. In the case of impedance calculation for a 17.78 cm times 10.16 cm printed circuit board (PCB) board, the proposed method has shown to be 12 times faster than conventional methods. This method can be applied to the analysis and design of power/ground-plane where complex computation is needed.
Induction of erythropoietin responsiveness in murine hematopoietic cells by the gag-myb-ets-containing ME26 virus

ME26 virus, which was generated by inserting the coding region of the acute avian leukemia-inducing virus E26 into a murine retrovirus vector, encodes a 135-kDa gag-myb-ets fusion protein. Amphotropic murine leukemia virus pseudotypes of ME26 virus induce a high incidence of erythroleukemia 2 to 4 months after injection into newborn NFS/N mice. Spleen cells from the majority of these mice proliferate to high levels in the presence of the erythroid hormone erythropoietin (Epo) and can easily be established as permanent Epo-dependent cell lines. The cell lines contain multiple copies of ME26 viral DNA and express viral message and protein. An Epo receptor mRNA of normal size can be detected in these cells, and binding studies reveal a single class of lower-affinity Epo receptor with an affinity for Epo that is in the range of that previously reported for erythroid cells. The ME26 virus-induced Epo-dependent cell lines, however, appear more immature than previously described erythroid cell lines and more closely resemble early hematopoietic precursor cells, suggesting that the virus may be activating the Epo receptor in hematopoietic cells that do not normally express it. Consistent with this idea, we are able to infect an interleukin-3-dependent myeloid cell line, FDC-P2, with ME26 virus and convert it to Epo dependence. The ME26 virus-infected FDC-P2 cells, even before growth on Epo, showed a large increase in the amount of Epo receptor mRNA. However, no ME26 viral integrations can be detected adjacent to the Epo receptor gene, indicating that the virus is not activating the Epo receptor gene by promoter/enhancer insertion. Our results are more consistent with the hypothesis that the gag-myb-ets-encoded viral fusion protein, which is known to bind DNA, is directly or indirectly activating the expression of the Epo receptor gene in these cells.
Diagnosis via arithmetic circuit compilation of Bayesian network and calculation on FPGA

Aircrafts, especially the Unmanned Aerial Vehicle (UAV) are always operating in environments filled with expectations and unforeseen occasions. In addition, hardware and software failures caused by design defects are inevitable [1]. In order to avoid catastrophic failure, we must locate the failure immediately in working condition. That means real-time diagnosis. Bayesian inference has been well established in the area of diagnosis and health management. In this paper, we come up with a method to take advantage of FPGA to implement Bayesian inference, which has the features of hardware programmable and the ability of parallel computing. Therefore, we compile the Bayesian Network into arithmetic circuit, and then evaluate the arithmetic circuit on FPGA.
Evaluating the introduction of joint crisis plans into routine clinical practice in four community mental health services

Objective: Our aim was to evaluate the implementation of joint crisis planning into routine clinical practice in community mental health services in Western Australia. Method: Four community mental health services, two metropolitan and two country based, were invited to participate in a 1-year pilot program to field test a crisis planning tool and the implementation process with a view to then rolling it out across Western Australia. Training and extensive support was offered to staff at the four sites. Results: Consumers experienced the process as both empowering and therapeutic. Despite acknowledgement of the value of interagency collaboration in the planning process, almost all plans were completed by consumers with their case managers. The most conspicuous finding was the marked difference in the number of completed plans at each site. Conclusions: This study supports previous research findings that joint crisis planning enhances the therapeutic relationship and empowers consumers. Organisational readiness was a major factor in the differential uptake of crisis plans between sites. Our study highlights the critical importance of addressing the context and culture of each individual service in which a new intervention is being introduced as part of the implementation process.
Nanoporous Silicon Produced by Metal-Assisted Etching: A Detailed Investigation of Optical and Contact Properties for Solar Cells

We present a detailed investigation of the optical and contact quality of silicon wafers textured using metal-assisted etching (MAE) to produce a nanoporous silicon (nSi) surface. We show that the solar weighted reflectance (Rw) of the bare optimized MAE nSi structure is only ~8%, and this is further reduced to 3% with the addition of an Al2O3/TiO2 stack. We also show that the optical path length enhancement can be >20 near the band edge of Si. The contact resistivity measurements of phosphorus-doped MAE nSi samples show that good contact can be made even on lightly doped samples, and we find no significant difference in contact quality between surfaces with different surface area enlargements (between ~2.2 and 2.7). This loosens constraints on finger width, helping to achieve reduced shading losses.
Sequential Minimal Optimization Approach for Content Based Image Retrieval

Content Based Image Retrieval (CBIR) is an emerging method to search and access images using either an image or the image dependent information as the query. Content-based image retrieval has huge advantage in medical field to provide doctors with a powerful tool to make accurate diagnosis. For CBIR to be effective, the system should be capable of retrieving images from the same disease class as the patient. In this paper we investigate the extraction of histogram from an image and use the Sequential minimal optimization technique to classify images via resampling.
Automatically Learning Android Malware Signatures from Few Samples

We propose a new technique for Android malware detection that combines the respective strengths of learningand signature-based approaches. Our approach uses a new learning algorithm based on Maximum Satisfiability (MaxSAT) to automatically synthesize semantic malware signatures from very few instances of a malware family. Our key insight is that the common functionality of a malware family can be summarized by patterns on the inter-component call graph (ICCG) representation of Android applications. Our approach synthesizes malware signatures by detecting maximally suspicious common subgraphs (MSCS) of a set of ICCGs using MaxSAT. We have implemented our approach in a tool called ASTROID, which is integrated into the existing APPOSCOPY tool for malware detection. Our experiments show that ASTROID can automatically infer better signatures than manually-written ones and outperforms state-of-the-art Android malware detectors such as DREBIN and MASSVET with respect to accuracy, false positives, and interpretability. Furthermore, ASTROID is very precise — in a corpus of 10,495 Google Play store apps, ASTROID only reported 8 as suspicious, and they were all in fact malicious.
Stimulation by fibronectin of macrophage-mediated phagocytosis of Pseudomonas aeruginosa

In a previous investigation it was determined that Pseudomonas aeruginosa cells taken directly from a mouse in vivo growth system were significantly more susceptible to nonopsonic phagocytosis by macrophages than were similar cells after being washed in buffer (N. M. Kelly, J. L. Battershill, S. Kuo, J. P. Arbuthnott, and R. E. W. Hancock, Infect. Immun. 55:2841-2843, 1987). It was demonstrated that a phagocytosis-promoting factor was found in the supernatant obtained from chambers incubated in the peritoneal cavities of laboratory mice or rats. The phagocytosis-promoting factor was effective with both strains of P. aeruginosa tested, using both unelicited mouse peritoneal macrophages and the P388D1 mouse macrophage cell line as the phagocytic cells. Phagocytosis enhancement was observed with in vivo-grown bacteria and with bacteria grown in vitro on agar plates, but not with bacteria grown in vitro with rapid agitation. Supernatants from mice and rats were fractionated using a fast pressure liquid chromatography gel exclusion column. The phagocytosis-promoting factor copurified with fibronectin. Furthermore, antifibronectin sera negated the phagocytosis-promoting activities of in vivo chamber supernatant, while commercial bovine fibronectin was itself capable of promoting phagocytosis. The concentrations of fibronectin increased in both rat and mouse peritoneal chambers with time, coincident with the ability of chamber supernatants to promote phagocytosis. It was concluded that fibronectin was the phagocytosis-promoting factor of chamber supernatants. Bacterial presence in the peritoneal chambers was not required to elicit fibronectin uptake into the chambers.
Two types of acquired idiopathic sideroblastic anaemia (AISA): a time‐tested distinction

In 1982, acquired idiopathic sideroblastic anaemia (AISA) was included by the French–American–British (FAB) Co‐operative Group in their classification of myelodysplastic syndromes (MDS). However, the malignant potentiality of AISA has always been a matter of debate. In different series, median survival and rates of transformation into acute myeloid leukaemia (AML) varied extensively. On cytomorphological grounds, AISA can be divided into pure (dyserythropoietic) sideroblastic anaemia (PSA), in which dysplasia is confined to erythropoietic cells, and a true myelodysplastic form (RARS), which is characterized by additional dysplastic features of granulopoiesis and/or megakaryopoiesis. In a previous study, based on retrospective analysis of 94 patients with AISA, we found that both types of sideroblastic anaemia differed considerably in terms of survival and risk of AML transformation. Almost identical results have now been obtained through a prospective study of 232 new patients with AISA. The difference in survival between PSA and RARS remained significant over the whole period of follow‐up (survival after 3 years being 77% vs. 56%; P = 0.003), and the incidence of AML did not increase with time in the PSA group, even in the long term. This prospective study strongly supported our conclusion that cytomorphological distinction between PSA and RARS provides valuable prognostic information.
Comparative Study of Wear of Enamel Induced by Alternating and Simultaneous Combinations of Abrasion and Erosion in vitro

Two types of interaction of erosive and abrasive forces with human enamel were analysed in an in vitro study. To simulate toothbrushing or chewing after an acidic challenge, enamel specimens were eroded in 0.3% citric acid (pH 3.2), then brushed with or without silica abrasive. To simulate simultaneous erosion and abrasion, as would occur during chewing of abrasive acidic food, enamel specimens were abraded in a toothbrushing machine, with and without silica abrasive, while immersed in citric acid. Enamel wear was measured by profilometry. In both experiments the combination of erosion and abrasion resulted in significantly greater wear than erosion alone, but no significant differences in wear after brushing with or without abrasive were found. Simultaneous erosion and abrasion resulted in about 50% more wear than alternating erosion and abrasion. It is concluded that softened enamel is highly unstable and potentially easily removed by short and relatively gentle physical action. Chewing of acidic foods with some abrasive properties might cause enhanced tooth wear.
Simulation of motor current waveforms in monitoring aortic valve state during ventricular assist device support

Monitoring of aortic valve (AV) opening and closure during left ventricular assist device (LVAD) heart pump support is crucial in preventing AV abnormalities and remodeling caused by anomalous resirculation. In this study, simulations of LVAD motor current waveforms were undertaken to investigate AV response to rotary blood pump assistance, as well as to detect AV open and close status under heart failure conditions. A two-dimensional fluid-structure interaction finite-element model is presented to predict AV state during LVAD outflow. The data will be useful in the development of a pump speed controller for optimal management of pump outflow.
Kernel-Based On-Line Object Tracking Combining both Local Description and Global Representation

SUMMARY This paper proposes a novel method for object tracking by combining local feature and global template-based methods. The proposed algorithm consists of two stages from coarse to ﬁne. The ﬁrst stage applies on-line classiﬁers to match the corresponding keypoints between the input frame and the reference frame. Thus a rough motion parameter can be estimated using RANSAC. The second stage employs kernel-based global representation in successive frames to reﬁne the motion parameter. In addition, we use the kernel weight obtained during the second stage to guide the on-line learning process of the keypoints’ description. Experimental results demonstrate the e ﬀ ectiveness of the proposed technique.