Miracle-dz/UniFAR-FTUs huggingface dataset:
Rendimiento psicométrico de la sexta versión del Addiction Severity Index en español (ASI-6)

Psychometric performance of the 6th version of the Addiction Severity Index in Spanish (ASI-6). This work analysed the psychometric properties of the 6th version of the Addiction Severity Index (ASI-6) translated and adapted to the Spanish language. A multicentre, observational and prospective design was used. A total of 258 participants were included, 217 were patients (35 stable patients and 182 unstable patients), and 41 were controls. The results show satisfactory psychometric performance of the ASI-6. The degree of the internal consistency of the standardized objective scores ranged between . 47 and . 95. As for test-retest reliability, the values were acceptable, varying from . 36 to 1. The study of the internal structure revealed a good fit to a unidimensional solution for all scales taken independently. Regarding convergent-discriminant validity, the correlations between the primary and secondary scales of the ASI-6 and the Clinic Global Impression score were low, with values from . 01 to . 26. Likewise, 8 of the 15 scales differentiated between controls and unstable patients. The psychometric properties of the ASI-6 Spanish version seem to be acceptable, though it is necessary to carry out new studies to test metric quality with independent samples of patients.
Biomarkers of Histone Deacetylase Inhibitor Activity in a Phase 1 Combined-Modality Study with Radiotherapy

Background Following the demonstration that histone deacetylase inhibitors enhanced experimental radiation-induced clonogenic suppression, the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study, combining fractionated radiotherapy with daily vorinostat for pelvic carcinoma, was designed to evaluate both clinical and novel biomarker endpoints, the latter relating to pharmacodynamic indicators of vorinostat action in clinical radiotherapy. Patients and Methods Potential biomarkers of vorinostat radiosensitizing action, not simultaneously manifesting molecular perturbations elicited by the radiation itself, were explored by gene expression array analysis of study patients' peripheral blood mononuclear cells (PBMC), sampled at baseline (T0) and on-treatment two and 24 hours (T2 and T24) after the patients had received vorinostat. Results This strategy revealed 1,600 array probes that were common for the comparisons T2 versus T0 and T24 versus T2 across all of the patients, and furthermore, that no significantly differential expression was observed between the T0 and T24 groups. Functional annotation analysis of the array data showed that a significant number of identified genes were implicated in gene regulation, the cell cycle, and chromatin biology. Gene expression was validated both in patients' PBMC and in vorinostat-treated human carcinoma xenograft models, and transient repression of MYC was consistently observed. Conclusion Within the design of the PRAVO study, all of the identified genes showed rapid and transient induction or repression and therefore, in principle, fulfilled the requirement of being pharmacodynamic biomarkers of vorinostat action in fractionated radiotherapy, possibly underscoring the role of MYC in this therapeutic setting.
MEDIDAS DO ESTRESSE: UMA REVISÃO NARRATIVA

This narrative review aimed to gather information on measures of stress according to the theoretical perspectives that underpins the methods of study in the area and also point out the evidences, characteristics and limitations of the various ways of measuring the phenomenon, favoring the better structuring of futures researches and consequent choice of measure methods of stress. Thereby, possibilities of measure are described according to the theoretical and empirical evidence that guides the researches on the topic, being divided between biological, environmental and self-perception measures of stress, respectively located in the response-based perspective, the stimulus- based perspective and the cognitive perspective. Finally, we sought encouraging the reflective stance of the researchers on the measurement methods and also the possible consideration of combined techniques for deeper scrutiny of stress.
Opportunistic Virtual Backbone Construction in Intermittently Connected Mobile Ad Hoc Networks

Data communication over intermittently connected mobile ad hoc networks (ICMANs) can be carried out by opportunistically employment of mobility nature of nodes and the storage space of all nodes. In order to overcome mobility randomness and subsequently uncertainty of future network state, multi-copy-based routing approaches are widely considered. However, scalability is still an issue, even extra routing information such as mobility statistics and context is employed to control the number of message copies. This is because communicating overhead to exchange all such information still exponentially increases as network size increases. Therefore, this paper introduces an opportunistic virtual backbone (VBB) constructing algorithm to form a hierarchical architecture over ICMANs. Once VBB is formed, all routing information and multiple message copies are limited among the VBB members, and thereby routing overhead can be reduced dramatically. Different from the conventional unit disk graph (UDG) based solutions for MANETs, the proposed algorithm utilizes a weighted graph derived from mobility statistics to model underlying long-term stable topology of ICMANs. To reduce constructing overhead, only partial two-hop mobility statistics are collected by each node. Moreover, intermittent connectivity and delayed message transmission are also addressed in the paper. The simulation results indicate that the proposed algorithm is highly scalable as network size increases and the existing SCF routing protocols can work well over ICMANs where VBBs are formed.
Patient-reported outcomes in support of oncology product labeling claims: regulatory context and challenges

The US FDA has advocated the patient-reported outcome (PRO) draft guidance as the main vehicle for evaluating PRO-based labeling claims for oncology drugs. In addition, FDA-affiliated researchers have identified factors inhibiting acceptance of health-related quality of life (HRQoL)-based claims for oncology product labels. The views of the FDA on PRO claims are extensive and prescriptive. By contrast, the European Medicines Agency (EMA) has conducted authorizations without an explicitly defined approach for evaluating HRQoL data. A reflective paper released in 2005 offered only broad recommendations on HRQoL labeling claims. The different approaches between the two regulatory agencies partly stem from underlying, divergent organizational characteristics. Moreover, general issues inherent in PRO research in oncology trials including trial design, missing data, multiplicity of end points and inconsistent findings of HRQoL data are discussed.
Extreme drought, host density, sex, and bullfrogs influence fungal pathogen infection in a declining lotic amphibian

Freshwater biodiversity is imperiled across the globe, and multiple stressors such as habitat alteration, non-native species invasion, disease, and climate change can act in concert to threaten vulnerable taxa. The amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd), which causes the disease chytridiomycosis, is one of the causative factors of severe amphibian declines. The foothill yellow-legged frog (Rana boylii) is a stream-breeding anuran endemic to California and Oregon (USA) that has declined precipitously in recent decades, yet there is little information on its susceptibility to Bd. In the fall of 2013, we observed dead and dying juvenile R. boylii in a San Francisco Bay Area watershed where annual amphibian breeding censuses have been conducted since 1997 in a free-flowing reach and since 2003 in an anthropogenically modified stream reach. High pathogen loads on R. boylii and histologic lesions observed on a dead R. boylii metamorph collected from the site were consistent with lethal chytridiomycosis. The outbreak coincided with extremely low stream flows in autumn that concentrated frogs in drying pools and the absence of high peak flows in winter that allowed non-native American bullfrogs (Rana catesbeiana) to expand their spatial distribution in the stream network. Following the outbreak, we surveyed R. boylii and sympatric anurans at the site for the next two years to determine Bd trends within the population. Using mixed-effects models, we found that bullfrog presence was a positive predictor of both Bd prevalence and Bd load in R. boylii. Prevalence was also influenced by sex and life stage: Adult males were more likely to be infected than either females or juveniles. Moreover, we found that stream flow volume was negatively associated with Bd load. These results indicate that disease, drought, and flow regulation may interact synergistically to impact amphibians in ways not previously recognized, informing stream flow management strategies for native aquatic taxa.
Modeling and Querying Semi-Structured data

We extend the model for semi-structured data proposed in (BUN 97), whe re both databases and schemas are represented as graphs, with the possibility o f expressing different types of constraints on the nodes of the graphs. We discuss how the expr essive power of the constraint language may influence the complexity of checking subsumptio n between schemas, and devise a polynomial algorithm for an interesting class of constraints. We then set up a framework for defining queries which are used to select graphs from a da tabase. The proposed query language allows for expressing sophisticated fixpoint properties o graphs and can be regarded as a basic building block of full-featured languages. We show tha t reasoning tasks at the basis of query optimization, such as query-schema comparison, query containment, and query satisfiability, are decidable.
Psychology and Adult Learning

1. Introduction 2. Humanistic Psychology and the Self-directed Learner 3. The Psychoanalytic Approach 4. Adult Development 5. Cognitive Developmental Psychology: Piaget and Kohlberg 6. Learning Styles 7. Behaviourism 8. Group Dynamics and the Group Facilitator 9. Critical Awareness 10. Concluding comment: Psychology as a Foundation Disipline in Adult Education Bibliography Index.
Unintentional and Intentional Recognition Rely on Dissociable Neurocognitive Mechanisms

Distractibility can lead to accidents and academic failures as well as memory problems. Recent evidence suggests that intentional recognition memory can be biased by unintentional recognition of distracting stimuli in the same environment. It is unknown whether unintentional and intentional recognition depend on the same underlying neurocognitive mechanisms. We assessed whether human participants' recognition of previously seen (old) or not seen (new) target stimuli was affected by whether a to-be-ignored distractor was old or new. ERPs were recorded to investigate the neural correlates of this bias. The results showed that the old/new status of salient distractors had a biasing effect on target recognition accuracy. Both intentional and unintentional recognition elicited early ERP effects that are thought to reflect relatively automatic memory processes. However, only intentional recognition elicited the later ERP marker of conscious recollection, consistent with previous suggestions that recollection is under voluntary control. In contrast, unintentional recognition was associated with an enhanced late posterior negativity, which may reflect monitoring or evaluation of memory signals. The findings suggest that unintentional and intentional recognition involve dissociable memory processes.
The potential roles of saturating and supersaturating contrast-response functions in conjunction detection: reply to Peirce.

Peirce (2007) proposed a two-stage conjunction detection model in which the outputs of first-stage neurons selective for the conjunction components were summed to give the conjunction-detector output. He argued that a saturating (monotonic) or supersaturating (nonmonotonic) nonlinearity on the outputs of the first-stage neurons made this detector more selective for conjunctions by increasing the ratio of conjunction response to component response at the output stage, i.e., the response of the conjunction detector to a conjunction divided by its response to a single component presented in isolation. The conjunction stimulus that Peirce considered was a maximum-contrast plaid, i.e., the sum of two 0.5contrast gratings of different orientation. The equivalent single-component stimulus was a single maximumcontrast grating. Assuming no cross-orientation inhibition, if the two first-stage neurons are each selective for a different component of the plaid, with a contrastresponse function r(c), where c is component contrast, then the sum of first-stage responses to the plaid is given by rconjunction1⁄4 2r(0.5), and the sum of first-stage responses to the grating is given by rcomponent 1⁄4 r(1). Peirce defined a conjunction selectivity index (CSI), which reflects the ratio of conjunction response to component response at the output stage of his proposed conjunction detector:
Contrast-enhanced ultrasound-guided radiofrequency ablation in inconspicuous hepatocellular carcinoma on B-mode ultrasound.

BACKGROUND/AIMS B-mode ultrasound (US) has difficulty targeting small hepatocellular carcinomas (HCCs) with poor conspicuity during radiofrequency ablation (RFA). Contrast-enhanced ultrasound (CEUS) can improve visualization of small or inconspicuous HCCs. This study was conducted to evaluate the effectiveness of CEUS-guided RFA electrode insertion during the arterial phase in inconspicuous HCCs. MATERIALS AND METHODS Ninety-three treatment-naïve HCCs from 80 patients treated with RFA from August 2012 to December 2014 were retrospectively reviewed. Seventy-five HCCs from 65 patients underwent B-mode US-guided RFA, and 15 HCCs from 14 patients that were inconspicuous on B-mode US underwent CEUS-guided RFA during the arterial phase after injection of sulfur hexafluoride microbubbles (SonoVue®). Technical success was assessed by contrast-enhanced computed tomography within 1 week and 3 months after the procedure. RESULTS The mean size of HCCs treated with CEUS-guided RFA was smaller than that of HCCs treated with B-mode US-guided RFA (1.17±0.36 vs. 1.63±0.55 cm, p=0.003). Technical success rates of CEUS-guided RFA within 1 week and 3 months were 100% (15/15) and 93.3% (14/15), respectively. Technical success rates of B-mode US-guided RFA were 97.3% (73/75) and 94.5% (69/73), respectively. CONCLUSION CEUS-guided RFA is highly efficacious for ablation of very small and inconspicuous HCCs.
Institutional Effects of Strategic Efforts at Community Enrichment

This article lays out a path for an institutional analysis of strategic interventions for collaboration. The analysis is informed by recent theorizing on structures and strategies for collaboration and by the insights of the new institutionalism found in recent work by organizational theorists. The article uses a framework of institutional propositions to guide an analysis of the strategic efforts to promote community collaborative effort to enhance the life chances of students, efforts that are evolving in one Canadian high school from the perspective of school leaders in the initiative. The article extends existing theoretical conceptions of school-community relations through analysis of the institutional effects of these strategic efforts at collaboration.
Towards personalized ubiquitous computing services

This technical report introduces goals and early findings of a multi-year multi-party project MUNDO. MUNDO is a pool of services and enablers for mobile and ubiquitous computing. It emphasizes easy global evolutionary deployment as a migration path for the Internet as a whole towards a nomadic computing economy. The nomadic users access the network via personal devices and associated public and private appliances. The network is liberated from common constraints such as central operators and fixed home bases of users. It hosts services which are by themselves migratable and highly adaptive with respect to region and context-awareness, quality variations, and terminal characteristics. Migration and adaptation may be realized by different implementations of the same service. An underlying general cost model helps to mediate user desires and service offerings. A number of scenarios and corresponding MUNDO application pools are described in order to motivate the features and scope of MUNDO. We describe a “radio on steroids” application pool called DACAR in more detail. We outline the architecture of MUNDO and elaborate its system services.
“If you’re not safe anywhere, you turn it inside yourself”: Narratives about childhood experiences told by 12 individuals diagnosed with psychosis

The aim was to study what patients diagnosed with psychosis related about early relationships with caregivers and about themselves as children. Data consisted of transcripts of 12 interviews, which were analyzed according to a thematic analysis. Through the narratives, a picture emerged of parents who had been unable to put aside their own difficulties and negative emotions. Parents were portrayed as sexually, physically, and/or emotionally abusive, often in tandem with a non-abusive parent described as passive. A family atmosphere marked by silence became visible. Further, a picture appeared of an introverted and “conformable” child, who had handled sadness, as well as fear, alone. Childhood strategies such as daydreaming and ”trying to become invisible” emerged. These strategies resemble what in other frames of reference are often regarded as childhood symptoms of schizophrenia spectrum disorders. Consequently, it could be questioned whether what are commonly viewed as early symptoms of schizophrenia might instead be the child’s attempts to adapt, in order to survive in a disorganized family.
In Vitro Susceptibilities of 27 Rickettsiae to 13 Antimicrobials

ABSTRACT The MICs of 13 antibiotics (doxycycline, thiamphenicol, rifampin, amoxicillin, gentamicin, co-trimoxazole, ciprofloxacin, pefloxacin, ofloxacin, erythromycin, josamycin, clarithromycin, and pristinamycin) were determined for 27 available rickettsial species or strains. We used two in vitro cell culture methods described previously: the plaque assay and the microplaque colorimetric assay. Our results confirm the susceptibilities of rickettsiae to doxycycline, thiamphenicol, and fluoroquinolones. Beta-lactams, aminoglycosides, and co-trimoxazole were not active. Typhus group rickettsiae were susceptible to all macrolides tested, whereas the spotted fever group rickettsiae,R. bellii, and R. canada were more resistant, with josamycin, a safe alternative for the treatment of Mediterranean spotted fever, being the most effective compound. Strain Bar 29,R. massiliae, R. montana, R. aeschlimannii, and R. rhipicephali, which are members of the same phylogenetic subgroup, were more resistant to rifampin than the other rickettsiae tested. Heterogeneity in susceptibility to rifampin, which we report for the first time, may explain in vivo discrepancies in the effectiveness of this antibiotic for the treatment of rickettsial diseases. We hypothesize that rifampin resistance and erythromycin susceptibility may reflect a divergence during the evolution of rickettsiae.
Human Altruism – Proximate Patterns and Evolutionary Origins

Abstract Are people selfish or altruistic? Throughout history this question has been answered on the basis of much introspection and little evidence. It has been at the heart of many controversial debates in politics, science, and philosophy. Some of the most fundamental questions concerning our evolutionary origins, our social relations, and the organization of society are centered around issues of altruism and selfishness. Experimental evidence indicates that human altruism is a powerful force and unique in the animal world. However, there is much individual heterogeneity and the interaction between altruists and selfish individuals is key for understanding the evolutionary dynamics as well as the proximate patterns of human cooperation. Depending on the environment, a minority of altruists can force a majority of selfish individuals to cooperate or, conversely, a few egoists can induce a large number of altruists to defect. Current gene-based evolutionary theories cannot explain important patterns of human altruism pointing towards the need for theories of cultural evolution and gene-culture coevolution.
Adjustable gamma correction reference voltage source for LCoS

In this paper, an adjustable gamma correction reference voltage source for Liquid Crystal on Silicon (LCoS) is proposed. The reference voltage source is taped out by Chartered 0. 35µm CMOS 2P4M Mixed-mode process, and the chip was tested. The test results indicate that the output of the chip can completely meet requirements of the common electronic field-inversion field sequential LCoS display system, and the setup time and accuracy of output voltage achieve the expected target.
Family language policy – the critical domain

Abstract Introducing a pioneering series of studies of family language policy and management, this paper points out that classic language policy dealt almost entirely with the nation-state, although it did recognise the critical role of the family in determining natural intergenerational transmission of a variety. After arguing for the need to look at each of the levels, or, rather, domains making up a speech or political community, it shows how these studies deal with internal pressures (such as ideology or grandparents) and external domains (especially the school) which aim to influence the family domain. More studies of these domains, including the family, are needed to provide a clear understanding of language policy.
Supplementary Material - Protein-protein interaction analysis

Table S1: Protein identification in PPI analysis. Protein Bait Method Prob Id pep Ass Score Quan pep FlaCE OE2402F indirect 1.00 2 20.04 1 FlaCE OE2402F direct 1.00 2 11.76 1 FlaCE OE2404R indirect 1.00 3 9.57 1 FlaD OE2404R indirect 1.00 3 12.85 2 OE2402F OE2401F direct 1.00 7 12.37 3 OE2402F CheD direct 1.00 2 10.58 1 OE2402F CheY direct 1.00 5 10.84 2 OE2402F CheC2 indirect 1.00 4 22.42 1 OE2404R CheD direct 1.00 3 14.62 2 OE2404R CheY indirect 1.00 2 16.26 1 OE2404R CheC2 indirect 1.00 4 25.87 1 CheD OE2401F direct 1.00 2 37.69 1 CheD CheC2 indirect 1.00 2 10.28 1 CheA CheY indirect 1.00 9 60.10 6
Development of autonomous vehicle - Overview of autonomous driving demonstration in ITS world Congress 2013

Recently, fully automated autonomous vehicles have been developed, and field examinations in public road have also been conducted, especially in United States. In this paper, preparation of our laboratory toward field examination of the autonomous vehicle is reported. Additionally, overview of demonstration in the ITS world Congress 2013 (ITSWC2013) is reported.
T-VEC: a tool for developing critical systems

This paper describes the specification-based testing and analysis tools, and associated processes, that were used to develop and certify safety-critical avionics systems in an industrial organization. These tools comprise an integrated development environment supporting specification acquisition and analysis, requirement-based automatic test vector generation, test coverage analysis, test driver generation, and test results analysis. The paper describes the specification model, method, development environment, and tool qualification approach. The capabilities of the automatic test generator are compared with foundational concepts and related testing strategies and mechanisms.