Miracle-dz/UniFAR-FTUs huggingface dataset:
Isotopic difference in trap loss collisions of laser cooled rubidium atoms.

We report measurements of collisional rate constants for cold Rb atoms held in a magneto-optical trap. 85 Rb and 87 Rb display significantly different behavior. At low trap laser intensities, atoms which undergo a hyperfine-changing collision gain sufficient velocity to escape the trap. Since the hyperfine splittings are quite different for the isotopes, the loss rates display a large isotopic dependence in this regime. At higher trap laser intensities, where trap loss is due to inelastic collisions involving excited atoms, a dramatic and unexpected isotopic dependence is seen
Software-Based Hardening Strategies for Neutron Sensitive FFT Algorithms on GPUs

In this paper we assess the neutron sensitivity of Graphics Processing Units (GPUs) when executing a Fast Fourier Transform (FFT) algorithm, and propose specific software-based hardening strategies to reduce its failure rate. Our research is motivated by experimental results with an unhardened FFT that demonstrate a majority of multiple errors in the output in the case of failures, which are caused by data dependencies. In addition, the use of the built-in error-correction code (ECC) showed a large overhead, and proved to be insufficient to provide high reliability. Experimental results with the hardened algorithm show a two orders of magnitude failure rate improvement over the original algorithm (one order of magnitude over ECC) and an overhead 64% smaller than ECC.
ISIA at the ImageCLEF 2017 Image Caption Task

This paper describes the details of our methods for participation in the caption prediction task of ImageCLEF 2017. The dataset we use is all provided by the organizers and doesn’t include any external resources. The key components of our framework include a deep model part, an SVM part and a caption retrieval part. In deep model part, we use an end to end architecture with Convolutional neural network (CNN) and a Long Short-Term Memory (LSTM) to encode and decode images and captions. According to the statistics of training dataset, we train different models with different lengths of captions. Then in SVM part, we use Support Vector Machine (SVM) to determine which model to use when generating the description for a test image. In this way, we can combine these models from the previous deep model part. In caption retrieval part, we use the image feature extracted from CNN and apply Nearest Neighbor method to retrieve the most similar image with caption in the training dataset. The final description is the aggregation of the generated sentence and the caption retrieved from the training dataset. The best performance of our 10 submitted runs ranks the 3rd in group which doesn’t use external resources.
EDAN20 Final Examination

De kan vinna Augustpriset Kultur & Nojen. Per Olov Enquist kan fa Augustpriset for tredje gangen. Det stod klart nar nomineringarna presenterades pa mandagen. Men Jonas Gardell blev utan nominering for sin romansvit "Torka aldrig tarar". Per Olov Enquist nomineras for "Liknelseboken". Forfattaren tog hem priset saval 1999 som 2008 med "Livlakarens besok" respektive "Ett annat liv". De ovriga nominerade i skonlitterara klassen ar Lena Andersson med "Egenmaktigt forfarande en roman om karlek", Sven Olov Karlssons "Porslinsfasaderna" och "Hagring 38" av Kjell Westo samt de tva poeterna Athena Farrokhzad med "Vitsvit" och Katarina Frostenson med "Tre vagar"
Island- and lake-like parallel adaptive radiations replicated in rivers

Parallel adaptive radiations have arisen following the colonization of islands by lizards and lakes by fishes. In these classic examples, parallel adaptive radiation is a response to the ecological opportunities afforded by the colonization of novel ecosystems and similar adaptive landscapes that favour the evolution of similar suites of ecomorphs, despite independent evolutionary histories. Here, we demonstrate that parallel adaptive radiations of cichlid fishes arose in South American rivers. Speciation-assembled communities of pike cichlids (Crenicichla) have independently diversified into similar suites of novel ecomorphs in the Uruguay and Paraná Rivers, including crevice feeders, periphyton grazers and molluscivores. There were bursts in phenotypic evolution associated with the colonization of each river and the subsequent expansion of morphospace following the evolution of the ecomorphs. These riverine clades demonstrate that characteristics emblematic of textbook parallel adaptive radiations of island- and lake-dwelling assemblages are feasible evolutionary outcomes even in labile ecosystems such as rivers.
A novel method of marking nipple areola complex in gynaecomastia surgery

Sir, There are various techniques of management of high grade gynaecomastia. Fat removal by liposuction in 3 planes — intraglandular, supraglandular and subglandular; excision of gland through a periareolar incision from 4 to 8 o’clock position leaving a small button of gland just below the nipple; or both. It should be followed by application of pressure garment for 3 months. Occasionally, after 6 weeks skin tightening device such as unipolar radio frequency may be required. Skin, by way of its elasticity, contracts beautifully.
Monitoring of Active HHV‐6 Infection in Bone Marrow Transplant Recipients by Real Time PCR; Comparison to Detection of Viral DNA in Plasma by Qualitative PCR

Twelve (46%) of the 26 patients had human herpesvirus 6 (HHV‐6) viremia after bone marrow transplant (BMT). All isolates were recovered from the samples obtained at 2 weeks after BMT. The sensitivity and the specificity of detection of viral DNA in plasma by qualitative polymerase chain reaction (PCR) for monitoring active virus replication were 92% and 97% respectively. Moreover, the positive (85%) and negative (99%) predictive values were also high. The patients with HHV‐6 viremia showed a clear peak in HHV‐6 DNA in peripheral blood mononuclear cells (PBMCs) at 2 weeks after BMT, which was measured by real time PCR. The virus DNA level in PBMCs between the two groups (patients with viremia and patients without viremia) was statistically different at 2 weeks after BMT (P = 0.033). In patients with HHV‐6 viremia, mean HHV‐6 DNA copy number was higher in the samples collected at 2 weeks after BMT than the samples collected at any other time period.
A Crypt-Specific Core Microbiota Resides in the Mouse Colon

ABSTRACT In an attempt to explore the microbial content of functionally critical niches of the mouse gastrointestinal tract, we targeted molecular microbial diagnostics of the crypts that contain the intestinal stem cells, which account for epithelial regeneration. As current evidence indicates, the gut microbiota affects epithelial regeneration; bacteria that are likely to primarily participate in this essential step of the gut, microbiota cross talk, have been identified. We show in this article that only the cecal and colonic crypts harbor resident microbiota in the mouse and that regardless of the line and breeding origin of these mice, this bacterial population is unexpectedly dominated by aerobic genera. Interestingly, this microbiota resembles the restricted microbiota found in the midgut of invertebrates; thus, the presence of our so-called “crypt-specific core microbiota” (CSCM) in the mouse colon potentially reflects a coevolutionary process under selective conditions that can now be addressed. We suggest that CSCM could play both a protective and a homeostatic role within the colon. This article is setting the bases for such studies, particularly by providing a bona fide—and essentially cultivable—crypt microbiota of reference. IMPORTANCE Metagenomic typing of the whole-gut luminal microbiome was recently provided, revealing great opportunities for physiological and physiopathological analysis of the host-microbiota interface. On this basis, it appears increasingly important to analyze which niches of the gut exposed to a particular microbiota are of major functional importance, specifically focusing on the crypt, which accounts for permanent epithelial renewal, and to analyze how this microbiota compares to its luminal counterpart in composition and quantity. Crypt-specific core microbiotas may show themselves as important elements regarding crypt protection and homeostasis of its functions. Metagenomic typing of the whole-gut luminal microbiome was recently provided, revealing great opportunities for physiological and physiopathological analysis of the host-microbiota interface. On this basis, it appears increasingly important to analyze which niches of the gut exposed to a particular microbiota are of major functional importance, specifically focusing on the crypt, which accounts for permanent epithelial renewal, and to analyze how this microbiota compares to its luminal counterpart in composition and quantity. Crypt-specific core microbiotas may show themselves as important elements regarding crypt protection and homeostasis of its functions.
Inflammatory pseudotumor of the trachea.

Primary tracheal tumors are extremely rare, and the majority of them are malignant. Inflammatory pseudotumor is a benign, tumorlike lesion, most likely of a reactive nature. Its basic morphologic characteristic is spindle cell (myoblasts and fibroblasts) proliferation with a variable number and type of inflammatory cells. A case of intratracheal inflammatory pseudotumor in a 14-year-old boy is presented together with a review of all similar lesions in the available literature. The discussion includes the presentation of tracheal tumors, their basic morphologic and immunohistochemical characteristics, and treatment modalities that are available. The surgeon must exercise caution not to perform radical surgery based on the initial pathologic diagnosis from the intraoperative frozen section, because the prognosis of these benign lesions generally is excellent. This is the second reported case of intratracheal inflammatory pseudotumor successfully endoscopically vaporized using a CO(2) laser, which is an excellent alternative in cases in which surgical treatment is feasible. J Pediatr Surg 36:631-634.
Methods of voltage synchronization in multiphase power conversion systems

Novel method (methodology) of synchronized pulsewidth modulation (PWM) is powerful instrumentation for elimination of sub-harmonics in the spectra of output voltage of both three-phase and multiphase voltage source inverters. This paper presents examples of dissemination of this new method for control of: a) five-phase inverters; b) six-phase inverters for drive system with symmetrical six-phase induction machine, and c) six-phase inverters for asymmetrical six-phase motor drive. Basic peculiarities of the method have been described. Simulations give a behavior of multiphase drive systems fed by inverters with basic continuous and discontinuous schemes of synchronized PWM, providing quarter-wave symmetry of the phase voltage during the whole control range.
Little Hans: A Centennial Review and Reconsideration

Freud's “Analysis of a Phobia in a Five-year-old Boy” (1909) has stimulated interminable “reanalysis. ” The case of Little Hans, an unprecedented experimental child analytic treatment, is reexamined in the light of newer theory and newly derestricted documents. The understanding of the complex overdetermination of Hans's phobia was not possible in the heroic age of psychoanalysis. Current analytic thought, as well as distance de-idealization vis-à-vis the pioneering past, has potentiated a reformation of the case. The severe disturbance of his mother had an adverse impact on Little Hans and his family. Her abuse of Hans's infant sister has been overlooked by generations of analysts. Trauma, child abuse, parental strife, and the preoedipal mother-child relationship emerge as important issues that intensified Hans's pathogenic oedipal conflicts and trauma. With limited, yet remarkable help from his father and Freud, Little Hans nevertheless had the ego strength and resilience to resolve his phobia, resume progressive development, and forge a successful creative career.
Expression Analysis of the Human Caspase-1 Subfamily Reveals Specific Regulation of the CASP5 Gene by Lipopolysaccharide and Interferon-γ*

Based on high sequence homology, there are six members in the caspase-1 subfamily: caspases 1, 4, 5, and 13 in humans and caspases 1, 11, and 12 in mice. Only caspase-1 is known to activate interleukin-1β and interleukin-18, and caspase-11 activates pro-caspase-1 in vivo. Almost nothing is known about caspases 4, 5, and 13. Here we report a sensitive and specific polymerase chain reaction system to analyze closely related genes. We employed this system to analyze the gene expression and regulation of human caspases 1, 4, 5, and 13, demonstrating that they have different expression patterns in normal tissues and cell lines. Interferon-γ strongly induced CASP1 and CASP5 but notCASP4 or CASP13 gene expression in HT-29 colon carcinoma cells. In contrast to the mRNA, interferon-γ up-regulated caspase-1 but not caspase-5 protein. In the monocytic cell line THP-1, CASP1 mRNA and caspase-1 protein are expressed constitutively, and their levels were not increased by lipopolysaccharide, whereas both CASP5 mRNA and caspase-5 protein were induced by lipopolysaccharide. Caspase-1 subfamily members displayed different in vitro activities toward pro-caspases 1 and 3 and pro-interleukin-1β. Our results demonstrate that caspase-1 and caspase-5 levels are modulated by interferon-γ and lipopolysaccharide, respectively, and suggest that caspase-1 subfamily members are differentially regulated and may have distinct functions.
Genome Sequence of Acinetobacter baumannii AC12, a Polymyxin-Resistant Strain Isolated from Terengganu, Malaysia

ABSTRACT Acinetobacter baumannii is a major cause of nosocomial infection worldwide. We report the draft genome sequence of A. baumannii AC12, a multidrug-resistant nosocomial strain with additional resistance to carbapenems and polymyxin. The genome data will provide insights into the genetic basis of antimicrobial resistance and its adaptive mechanism.
Hybrid algorithm based on Chemical Reaction Optimization and Lin-Kernighan local search for the Traveling Salesman Problem

Chemical Reaction Optimization (CRO) is a new heuristic optimization method mimicking the process of a chemical reaction where molecules interact with each other aiming to reach the minimum state of free energy. CRO has demonstrated its capability in solving NP-hard optimization problems. The Lin-Kernighan(LK) local search is known to be one of the most successful heuristics for the Traveling Salesman Problem (TSP). In this paper, we present a hybrid algorithm based on CRO and LK local search for TSP. The proposed algorithm consider the tradeoff between the exploration abilities of CRO and the exploitation abilities of LK local searcher. Experimental results show that the proposed algorithm is efficient.
Pattern for Re-engineering a Term-based Thesaurus, which Follows the Record-based model, to a Lightweight Ontology

This pattern for re-engineering non-ontological resources (PR-NOR) ﬁts in the Schema Re-engineering Category proposed by [3]. The pattern deﬁnes a procedure that transforms the term-based thesaurus components into ontology representational primitives. This pattern comes from the experience of ontology engineers in developing ontologies using thesauri in several projects (SEEMP 1 , NeOn 2 , and Knowledge Web 3 ). The pattern is included in a pool of patterns, which is a key element of our method for re-engineering non-ontological resources into ontologies [2]. The patterns generate the ontologies at a conceptualization level, independent of the ontology implementation language.
Economic Analysis of Rapid and Sensitive Polymerase Chain Reaction Testing in the Emergency Department for Influenza Infections in Children

Background: Rapid multiplex polymerase chain reaction (PCR) assays simultaneously detect several respiratory viral pathogens with high sensitivity. Maximizing detection of influenza at the point of care has the potential to reduce unnecessary antibiotic use, laboratory tests and hospitalizations. However, the cost-effectiveness of rapid multiplex PCR assays for influenza has not been compared with other diagnostic methods in children. Methods: For children presenting to the emergency department with influenza-like illness, we compared costs and outcomes using 4 different testing strategies for detection of influenza: (1) a rapid multiplex PCR platform (FilmArray); (2) traditional PCR; (3) direct-fluorescent antibody and (4) rapid antigen tests. Costs were assessed from the hospital perspective, and effectiveness was defined as quality-adjusted life years (QALYs). Input parameters were obtained from previous studies, and the model was run separately for children aged 3–36 months and 3–18 years. Results: Rapid multiplex PCR testing was the most effective testing strategy for children in both age groups. The incremental cost-effectiveness when compared with rapid antigen tests was $115,556 per QALY for children aged 3–36 months and from $228,000 per QALY for children aged 3–18 years. The cost-effectiveness of rapid multiplex PCR was sensitive to estimates for influenza prevalence, the proportion of patients treated with antivirals and the cost per test. Conclusions: Our model identifies scenarios in which identification of influenza in the emergency department using rapid multiplex PCR testing is a cost-effective strategy for infants and children 3 months through 18 years. Including detection of other respiratory viruses in the analysis would further improve cost-effectiveness.
Antiangiogenic evaluation of ZnWO4 nanoparticles synthesised through microwave-assisted hydrothermal method

Abstract Angiogenesis, the complex process of formation of new blood vessels from pre-existing blood vessels, which involves the participation of several pro- and anti-angiogenic factors, is implicated in many physiological and pathological conditions. Nanoparticle-based anti-angiogenic activity at the tumour tissue, harnessed by the Enhanced Permeability and Retention Effect (EPR effect), could potentially become a breakthrough therapy to halt tumour progression. Herein, we evaluate the anti-angiogenic effect of ZnWO4 nanoparticles (NPs). The nanoparticles were obtained by microwave-assisted hydrothermal synthesis (MAHS) at 120 °C for 60 min and were structurally characterised by X-ray diffraction (XRD) and micro-Raman (MR) spectroscopy. The mean size and polydispersity index were estimated by Zeta potential analysis. The XRD analysis revealed structural organisation at a long-range order, with an average crystallite size of around 3.67 nm, while MR revealed short-range order for ZnWO4. The anti-angiogenic potential of zinc tungstate nanoparticles was investigated through the chorioallantoic membrane assay (CAM) using fertilised chicken eggs. We demonstrate, in an unprecedented way, that nanocrystalline ZnWO4 NPs obtained by MAHS, at low reaction temperatures, showed excellent anti-angiogenic properties even at low concentrations. The ZnWO4 NPs were further evaluated for its cytotoxicity in vitro.
Structural Basis for Homodimerization of the Src-associated during Mitosis, 68-kDa Protein (Sam68) Qua1 Domain*♦

Sam68 (Src-associated during mitosis, 68 kDa) is a prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. STAR proteins bind mRNA targets and modulate cellular processes such as cell cycle regulation and tissue development in response to extracellular signals. Sam68 has been shown to modulate alternative splicing of the pre-mRNAs of CD44 and Bcl-xL, which are linked to tumor progression and apoptosis. Sam68 and other STAR proteins recognize bipartite RNA sequences and are thought to function as homodimers. However, the structural and functional roles of the self-association are not known. Here, we present the solution structure of the Sam68 Qua1 homodimerization domain. Each monomer consists of two antiparallel α-helices connected by a short loop. The two subunits are arranged perpendicular to each other in an unusual four-helix topology. Mutational analysis of Sam68 in vitro and in a cell-based assay revealed that the Qua1 domain and residues within the dimerization interface are essential for alternative splicing of a CD44 minigene. Together, our results indicate that the Qua1 homodimerization domain is required for regulation of alternative splicing by Sam68.
Study of cognitive flexibility at different stress levels with background music

The aim of this project is to study the effect of cognitive flexibility at different stress levels. Stroop color-word test is used to identify the cognitive performance at 3 different stress levels with/without the presence of background music. A pre-test PSS (Perceived Stress Scale) questionnaire is given to participants to categorize them into different stress groups. EEG signals were collected before and during the test and the absolute power of the beta brainwave activity was calculated. For the congruent test, the mean beta absolute power ratio is increased by 0.068 when compared to the baseline value. For the incongruent test, the mean beta absolute power ratio increased by 0.134 compared to the congruent test. For the congruent test with music, the mean beta absolute power ratio is increased by 0.261. For the incongruent test with music, there is a significant increase in time taken for higher stress group to complete the test. The higher the stress; the longer it takes to complete the incongruent test. This shows that music can cause distraction to the participants under higher stress conditions. The mean beta absolute power ratio is increased by 0.246 in this case.
Antipsychotic combination using low-dose antipsychotics is as efficacious and safe as, but cheaper, than optimal-dose monotherapy in the treatment of schizophrenia: a randomized, double-blind study

The use of antipsychotic combination has been increasing during the last decade. This study aimed to compare the efficacy and safety of low-dose amisulpride plus low-dose sulpiride with full-dose amisulpride in the treatment of acute schizophrenia. In this 6-week, double-blind, fixed-dose study, patients were randomized to antipsychotic combination (400 mg/day amisulpride plus 800 mg/day sulpiride, N=46) or monotherapy (800 mg/day amisulpride, N=46) groups. Efficacy measurements included the Positive and Negative Syndrome Scale (PANSS) and subscales, and other scales. Safety and quality of life were also assessed. Response was defined as a 30% reduction in the PANSS total score. Both groups were similar in terms of the following: (a) clinical characteristics at baseline, (b) response rates, and (c) score changes in all psychopathology measures, quality of life, and all side-effect scales after 6 weeks of treatment. There were also no significant between-group differences in changes in other safety measurement. However, the combination strategy did reduce treatment costs. The current study suggests that an antipsychotic combination of low-dose antipsychotics is as efficacious and safe as, but cheaper than, optimal-dose monotherapy in the treatment of schizophrenia.