Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulation of ankyrin repeat and suppressor of cytokine signalling box protein 4 expression in the immortalized murine endothelial cell lines MS1 and SVR: a role for tumour necrosis factor alpha and oxygen

During vascular development, endothelial cells are exposed to a variety of rapidly changing factors, including fluctuating oxygen levels. We have previously shown that ankyrin repeat and suppressor of cytokine signalling box protein 4 (ASB4) is the most highly differentially expressed gene in the vascular lineage during early differentiation and is expressed in the embryonic vasculature at a time when oxygen tension is rising because of the onset of placental blood flow. To further our understanding of the regulation of ASB4 expression in endothelial cells, we tested the effect of various stressors for their ability to alter ASB4 expression in the immortalized murine endothelial cell lines MS1 and SVR. ASB4 expression is decreased during hypoxic insult and shear stress, whereas it is increased in response to tumour necrosis factor alpha (TNF‐α). Further investigation indicated that nuclear factor kappa B (NF‐κB) is the responsible transcription factor involved in the TNF‐α‐induced upregulation of ASB4, placing ASB4 downstream of NF‐κB in the TNF‐α signalling cascade and identifying it as a potential regulator for TNF‐α's numerous functions associated with inflammation, angiogenesis and apoptosis. Copyright © 2011 John Wiley & Sons, Ltd.
UWB Short-Range Bifocusing Tomographic Imaging

In this paper, the capability of ultra-wideband (UWB) sensor arrays for tomographic imaging of electrically large objects in 2-D and 3-D environments is presented. One of the main concerns when imaging extended real objects is the capability of the system to correctly reconstruct the object cross-section electric properties. An imaging method using a UWB multifrequency bifocusing (UWB-MFBF) operator with good tomographic imaging capabilities is presented, and numerical simulations are conducted to obtain the basic geometry and sampling parameters for a good-quality image reconstruction for geometrical and electrical parameters. Canonical-shape experimental reconstructions are performed to validate the established criteria.
YNU-HPCC at SemEval 2017 Task 4: Using A Multi-Channel CNN-LSTM Model for Sentiment Classification

In this paper, we propose a multi-channel convolutional neural network-long short-term memory (CNN-LSTM) model that consists of two parts: multi-channel CNN and LSTM to analyze the sentiments of short English messages from Twitter. Un-like a conventional CNN, the proposed model applies a multi-channel strategy that uses several filters of different length to extract active local n-gram features in different scales. This information is then sequentially composed using LSTM. By combining both CNN and LSTM, we can consider both local information within tweets and long-distance dependency across tweets in the classification process. Officially released results show that our system outperforms the baseline algo-rithm.
Development and validation of Arabic version of the douleur neuropathique 4 questionnaire

Introduction: The douleur neuropathique 4 (DN4) questionnaire is a widely used tool for diagnosis of neuropathic pain (NP). The aim was to translate, culturally adapt, and validate the DN4 questionnaire in Arabic. Methods: A systematic translation process was used to translate the original English DN4 into Arabic. After the pilot study, the Arabic version was validated among patients with chronic pain in two tertiary care centers. The reliability of the translated version was examined using internal consistency, test-retest reliability, and intraclass correlation coefficients. We examined the validity of the Arabic DN4 via construct validity, concurrent validity (associations with the numeric rating scale, brief pain inventory, and Self-Completed Leeds Assessment of Neuropathic Symptoms and Signs [S-LANSS]), face validity, and diagnostic validity. To investigate the responsiveness, the translated DN4 was administered twice among the same group of patients. Results: A total of 142 subjects (68 men, 74 women) were included in the study. Cronbach's α was 0.67 (95% confidence interval [CI]: 0.59–0.75), and interclass correlation coefficients was 0.81 (95% CI: 0.76–0.87). The DN4 was moderately associated with the S-LANSS questionnaire. Results showed our Arabic DN4 to have good diagnostic accuracy, with area under the curve of 0.88 (95% CI: 0.82–0.94). As with the original version, a score of ≥4 was found to be the best cut-off for the diagnosis of NP, with a sensitivity of 88.31%, specificity of 74.47%, a positive predictive value of 85%, and a negative predictive value of 80%. Most patients found the DN4 questionnaire to be clear and easy to understand, and thought the questionnaire items covered all their problem areas regarding their pain. Conclusion: Our Arabic version of the DN4 is a reliable and valid screening tool that can be easily administered among patients to differentiate between NP and non-NP.
Two 16S-23S ribosomal DNA intergenic regions in different Treponema pallidum subspecies contain tRNA genes.

The 16S-23S intergenic spacers of Treponema pallidum subspecies pallidum, Nichols strain, and Treponema pallidum subspecies pertenue, Gauthier strain, have been cloned, characterized and sequenced. Isoleucine and alanine tRNA genes have been identified within the 16S-23S intergenic regions on separate alleles of 293 and 303 bases, respectively. The two alleles are present in both T.p.pallidum and T.p. pertenue, and show no sequence differences between the bacterial subspecies. The ile-tRNA and ala-tRNA genes show 65% and 84% sequence identity, respectively, with the homologous genes of the related spirochete, Borrelia burgdorferi.
Understanding the out-of-body experience from a neuroscientific perspective

The self is a multifaceted entity. Studies of the self as it relates to the body (the ‘bodily self’) have revealed three crucial aspects of bodily self-consciousness: (1) ownership (2) self-location and (3) visuo-spatial perspective. The normal bodily self includes the representation of an owned body (1), and the self is experienced as being localized within this owned body (embodied), at a definite location in space (2). Moreover, in healthy humans, the external world is experienced from this location, i.e. consciousness has an inherent visuo-spatial perspective (3) whose origin normally coincides with self-location. Scientists have only very recently begun to investigate the links between these different aspects and their underlying neural bases (Arzy, Seeck, Ortigue, Spinelli, & Blanke, 2006a; Aspell, Lenggenhager, & Blanke, 2009; Ehrsson, 2007; Ehrsson & Petkova, 2008; Lenggenhager, Mouthon, & Blanke, 2009; Lenggenhager, Tadi, Metzinger, & Blanke, 2007). Here we argue that the scientific understanding of the bodily self can be informed by the study of OBEs because these aspects of the self are experienced as spatially distinct from the physical body during these experiences (Blanke, Landis, Spinelli, & Seeck, 2004). How is it possible that these features of the bodily self can ‘come apart’ in an OBE? The study of what causes them to dissociate in an OBE and the examination of how these aspects of the bodily self relate to behavior and neural processing in healthy subjects will provide important insights into how these aspects of self are related: phenomenally, behaviorally and neurally.
The GTOP database in 2009: updated content and novel features to expand and deepen insights into protein structures and functions

The Genomes TO Protein Structures and Functions (GTOP) database (http://spock.genes.nig.ac.jp/~genome/gtop.html) freely provides an extensive collection of information on protein structures and functions obtained by application of various computational tools to the amino acid sequences of entirely sequenced genomes. GTOP contains annotations of 3D structures, protein families, functions, and other useful data of a protein of interest in user-friendly ways to give a deep insight into the protein structure. From the initial 1999 version, GTOP has been continually updated to reap the fruits of genome projects and augmented to supply novel information, in particular intrinsically disordered regions. As intrinsically disordered regions constitute a considerable fraction of proteins and often play crucial roles especially in eukaryotes, their assignments give important additional clues to the functionality of proteins. Additionally, we have incorporated the following features into GTOP: a platform independent structural viewer, results of HMM searches against SCOP and Pfam, secondary structure predictions, color display of exon boundaries in eukaryotic proteins, assignments of gene ontology terms, search tools, and master files.
PatchWork : an adaptive multi-hop virtual infrastructure for dense mobile ad-hoc networks

Message routing in dense mobile ad-hoc networks generally requires an infrastructure comprising static nodes, localization systems like GPS for use with geographical routing, or both. The case where such assumptions do not hold has yet to be solved. One approach is to establish a virtual infrastructure that is semi-stable, even when the nodes themselves are highly mobile. This paper introduces PatchWork, an adaptive and selfassembling network overlay comprised of mobile agents, called relays, that actively move between mobile nodes. Hop-count estimation is used to space the relays equidistantly in the network at multi-hop distances. The overlay structure is self assembling and self healing, and is created spontaneously without the need for initial seeds. This makes the overlay resistant to random node failure, and network splits and merges. We make use of gossiping instead of scoped flooding to estimate hop-count distance. We show that only a limited number of local message exchanges are sufficient at each time interval, and propose an adaptive scheme that exploits this property. We show by extensive simulation that PatchWork is stable in networks with densities of 15 neighbors and up, even in the face of high mobility, and is resistant to various network dynamics such as message loss and random node failures.
On the stability of walking systems

We reconsider here the stability criteria usually proposed for the analysis of walking systems, exhibiting their limits and their ambiguity. We propose then some new criteria based on a thorough analysis of the dynamics of walking systems and precise deﬁnitions concerning their stability. Numerical methods are presented then to deal with these new criteria.
Theoretical Computer

We show that given a k -bounded pseudo-Boolean function f , one can always compute the c th moment of f over regions of arbitrary radius in Hamming space in polynomial time using algebraic information from the adjacency structure (where k and c are constants). This result has implications for evolutionary algorithms and local search algorithms because information about promising regions of the search space can be efficiently retrieved, even if the cardinality of the region is exponential in the problem size. Finally, we use our results to introduce a method of efficiently calculating the expected fitness of mutations for evolutionary algorithms.
Robotic submerged microhandling controlled by pH swithching

Robotic microhandling is a promising way to assemble microcomponents in order to manufacture new generation of Hybrid Micro ElectroMechanical Systems (HMEMS). However, at the scale of several micrometers, adhesion phenomenon highly perturbs the micro-objects release and the positioning. This phenomenon is directly linked to both the object and the gripper surface chemical composition. We propose to control adhesion by using chemical self-assembly monolayer (SAM) on both surfaces. Different types of chemical functionalisation have been tested and this paper only focuses on the presentation of aminosilane grafted (3 (ethoxydimethylsilyl) propyl amine (APTES) and (3 aminopropyl) triethoxysilane (APDMES)). We show that the liquid pH can be used to modify the adhesion and to switch from an attractive behaviour to a repulsive behaviour. The pH control can thus be used to increase adhesion during handling and cancel adhesion during release. Experiments have shown that the pH control is able to control the release of a micro-object. This paper shows the relevance of a new type of reliable submerged robotic microhandling principle, which is based an adjusting chemical properties of liquid.
In Vitro–In Vivo Correlation: Importance of Dissolution in IVIVC

Introduction Correlations between in vitro and in vivo data (IVIVC) are often used during pharmaceutical development in order to reduce development time and optimize the formulation. A good correlation is a tool for predicting in vivo results based on in vitro data. IVIVC allows dosage form optimization with the fewest possible trials in man,fixes dissolution acceptance criteria,and can be used as a surrogate for further bioequivalence studies; it is also recommended by regulatory authorities (1–5). Many studies reported in the late ’70s and early ’80s established the basic concept of IVIVC (6). Various definitions of in vitro–in vivo correlation have been proposed by the International Pharmaceutical Federation (FIP), the USP working group (7),and regulatory authorities such as the FDA or EMEA (2–5). The FDA (2) defines IVIVC as “a predictive mathematical model describing the relationship between an in vitro property of an extended release dosage form (usually the rate or extent of drug dissolution or release) and a relevant in vivo response,e.g.,plasma drug concentration or amount of drug absorbed. ” As stressed in this definition, IVIVC is more an in vitro–in vivo relationship than a strict correlation. It should be kept in mind that a relationship does not imply a causality link between the in vitro data, in our case,and the in vivo data. Bases on the type of data used to establish the relationship, three main levels are defined by the FDA:
IPv6 flow handoff in ad hoc wireless networks using mobility prediction

In an ad hoc wireless network, mobile hosts are acting as routers and the network topology is constantly changing due to node mobility. The disruptions can cause serious degradation for real-time session. This paper describes a new protocol, the flow oriented routing protocol (FORP), for routing real-time IPv6 flows (e.g., voice and data) in highly mobile ad hoc wireless networks. A new concept called "multi-hop handoff" is introduced to anticipate topological changes and perform rerouting, thus limiting the disruption of a flow due to the changing topology. The performance of the proposed scheme is compared to other routing approaches.
The SAGE handbook of mentoring and coaching in education

Introduction PART ONE: THEORIES OF MENTORING AND COACHING Mentoring: An Overview - Carol A. Mullen Coaching: An Overview - Sarah J. Fletcher PART TWO: SKILLS, VALUES AND UNDERSTANDINGS Improving Coaching by and for School Teachers - David Leat, Rachel Lofthouse and Carl Towler Fostering Face-to-Face Mentoring and Coaching - Andrew J. Hobson Fostering Web-Based Mentoring and Coaching - Sarah J. Fletcher Operationalizing Phases of Mentoring Relationships - Carol A. Mullen and Dale H. Schunk PART THREE: CULTURALLY BASED CONCEPTS Educating the Critically Reflective Mentor - Geraldine Mooney Simmie and Joanne Moles Politics and Systems of Coaching and Mentoring - Andrew Hargreaves and Jane Skelton Apprenticeship or Co-Enquiry? - Tadashi Asada and Sarah J Fletcher Effects of Race and Racial Dynamics on Mentoring - Juanita Johnson-Bailey Mentoring Innovation through Online Communications in a Digital Culture - Helga Dorner Perspectives on Culture and Mentoring in the Global Age - Frances K. Kochan and Joseph T. Pascarelli PART FOUR: SCHOOL CONTEXTS Mentoring and Coaching for School Teachers' ITE and Induction - Pete Sorensen Mentoring and Coaching for Teachers' Continuing Professional Development - Philippa Cordingley and Natalia Buckler A Critical-Constructivist Perspective on Mentoring and Coaching for Leadership - Gary M. Crow Mentoring and Coaching for Leadership Development in Schools - Chris Rhodes Dialogical Mentoring and Coaching in Early Years Leadership - Paul Watling and Mike Gasper Coaching in the K-12 Context - Joellen Killion Using Mentoring and Coaching for Professional Learning in UK Secondary Schools - Cathy Pomphrey and Suzanne Burley Multidimensional Understandings of School-Based Mentoring - Ko Po-yuk, Mun-ling Lo and John Chi-kin Lee Mentoring Student Teachers in Professional Development Schools in Israel - Maureen Rajuan PART FIVE: ADULT AND HIGHER EDUCATION CONTEXTS Mentoring Doctoral Students in Educational Leadership Programs - Ken Young and Sandra Harris Mentoring and Coaching in Further Education - Janet Oti Empowerment in the Faculty-Student Mentoring Relationship - Catherine A. Hansman Student Peer-Mentors as Navigational Resource in Higher Education - Jenepher Lennox Terrion PART SIX: INCLUSION Using Best Practices for Teaching the Process of Coaching - Hal Portner and Mary H. Portner Mentoring Graduate Students of Color - Richard J. Reddick and Michelle D. Young The Role of Mentoring in Adult Literacy and Numeracy in Northern Ireland - Shelley Tracey Peer Mentoring and Inclusion in Writing Groups - Dannielle Joy Davis, Kara Provost and Sonya Clark PART SEVEN: RESEARCH ISSUES E-Mentoring and Educational Research Capacity Development: A Conceptual Perspective - Norbert Pachler and Ana Redondo Knowledge Base of Mentoring and Mentor Preparation - Sylvia Yee Fan Tang Mentoring teacher inquiry: Lessons in Lesson Study - Susan Groundwater-Smith Research Mentoring In Higher Education - Jean Rath
Dichotomy of AML1-ETO Functions: Growth Arrest versus Block of Differentiation

ABSTRACT The fusion gene AML1-ETO is the product of t(8;21)(q22;q22), one of the most common chromosomal translocations associated with acute myeloid leukemia. To investigate the impact of AML1-ETO on hematopoiesis, tetracycline-inducible AML1-ETO-expressing cell lines were generated using myeloid cells. AML1-ETO is tightly and strongly induced upon tetracycline withdrawal. The proliferation of AML1-ETO+ cells was markedly reduced, and most of the cells eventually underwent apoptosis. RNase protection assays revealed that the amount of Bcl-2 mRNA was decreased after AML1-ETO induction. Enforced expression of Bcl-2 was able to significantly delay, but not completely overcome, AML1-ETO-induced apoptosis. Prior to the onset of apoptosis, we also studied the ability of AML1-ETO to modulate differentiation. AML1-ETO expression altered granulocytic differentiation of U937T-A/E cells. More significantly, this change of differentiation was associated with the down-regulation of CCAAT/enhancer binding protein α (C/EBPα), a key regulator of granulocytic differentiation. These observations suggest a dichotomy in the functions of AML1-ETO: (i) reduction of granulocytic differentiation correlated with decreased expression ofC/EBPα and (ii) growth arrest leading to apoptosis with decreased expression of CDK4, c-myc, andBcl-2. We predict that the preleukemic AML1-ETO+ cells must overcome AML1-ETO-induced growth arrest and apoptosis prior to fulfilling their leukemogenic potential.
Temporal rhythms in adolescence : clocks, calendars, and the coordination of daily life

1. Neighborhood Rhythms and the Social Activities of Adolescent Mothers(Linda M. Burton, Joan E. Graham). 2. Ups and Downs: Daily Cylces of Adolescent Moods(Bonnie L. Barber, Kristen C. Jacobson, Kristelle E. Miller, Anne C. Petersen). 3. Waiting for the WeekAnd: Friday and Saturday Nights as the Emotional Climax of the Week(Reed Larson, Maryse Richards). 4. Weekly Rhythms of Parents' Work Stress, Home Stress, and Parent--Adolescent Tension(David M. Almeida, Daniel McDonald). 5. Seasonal and Weekly Rhythms: Windows into Variability in Family Socialization Experiences in Early Adolescence(Ann C. Crouter, Mary Corinne Maguire). 6. Implications for Policy and Practice: Getting Adolescents, Families, and Communities in Sync(Reed Larson).
Lectin-Mediated Retention of p62 Facilitates p62-E1 Heterodimerization in Endoplasmic Reticulum of Semliki Forest Virus-Infected Cells

ABSTRACT The Semliki Forest virus (SFV) spike subunits p62 and E1 are made from a common coding unit in the order p62-E1. The proteins are separated by the host signal peptidase upon translocation into the endoplasmic reticulum (ER). Shortly thereafter, p62 and E1 form heterodimers. Heterodimerization preferentially occurs between subunits derived from the same translation product, so-called cis heterodimerization. As the p62 protein has the capacity to leave the ER in the absence of E1, it has been postulated that there exists a retention mechanism for the p62 protein, putatively at or near the translocon, in the ER in order to promote cis heterodimerization (B. U. Barth and H. Garoff, J. Virol. 71:7857-7865, 1997). Here we show that there exists such a mechanism, that it is at least in part mediated by the ER chaperones calnexin and calreticulin, and that the retention is important for efficient cis heterodimerization.
Probabilistic linear discriminant analysis of i-vector posterior distributions

The i-vector extraction process is affected by several factors such as the noise level, the acoustic content of the observed features, and the duration of the analyzed speech segment. These factors influence both the i-vector estimate and its uncertainty, represented by the i-vector posterior covariance. This paper present a new PLDA model that, unlike the standard one, exploits the intrinsic i-vector uncertainty. Since short segments are known to decrease recognition accuracy, and segment duration is the main factor affecting the i-vector covariance, we designed a set of experiments aiming at comparing the standard and the new PLDA models on short speech cuts of variable duration, randomly extracted from the conversations included in the NIST SRE 2010 female telephone extended core condition. Our results show that the new model outperforms the standard PLDA when tested on short segments, and keeps the accuracy of the latter for long enough utterances. In particular, the relative improvement is up to 13% for the EER, 5% for DCF08, and 2.5% for DCF10.