Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of emotional distress and pain-related fear on patients with chronic pain: Subgroup analysis of patients referred to multimodal rehabilitation.

OBJECTIVE Multimodal rehabilitation programmes (MMRP) for chronic pain could be improved by determining which patients do not benefit fully. General distress and pain-related fear may explain variations in the treatment effects of MMRP. DESIGN Cohort study with a cross-sectional, prospective part. PATIENTS Chronic musculoskeletal pain patients referred to 2 hospital-based pain rehabilitation clinics. METHODS The cross-sectional part of this study cluster analyses patients (n = 1,218) with regard to distress and pain-related fear at first consultation in clinical pain rehabilitation and describes differences in external variables between clusters. The prospective part follows the subsample of patients (n = 260) participating in MMRP and describes outcome post-treatment. RESULTS Four distinct subgroups were found: (i) those with low levels of distress and pain-related fear; (ii) those with high levels of pain-related fear; (iii) those with high levels of distress; and (iv) those with high levels of distress and pain-related fear. These subgroups showed differences in demogra-phics, pain characteristics, quality of life, and acceptance, as well as the degree of MMRP participation and MMRP outcome. CONCLUSION Among patients with chronic pain referred to MMRP there are subgroups with different profiles of distress and pain-related fear, which are relevant to understanding the adaptation to pain and MMRP outcome. This knowledge may help us to select patients and tailor treatment for better results.
An atypical member of the light-harvesting complex stress-related protein family modulates diatom responses to light

Diatoms are prominent phytoplanktonic organisms that contribute around 40% of carbon assimilation in the oceans. They grow and perform optimally in variable environments, being able to cope with unpredictable changes in the amount and quality of light. The molecular mechanisms regulating diatom light responses are, however, still obscure. Using knockdown Phaeodactylum tricornutum transgenic lines, we reveal the key function of a member of the light-harvesting complex stress-related (LHCSR) protein family, denoted LHCX1, in modulation of excess light energy dissipation. In contrast to green algae, this gene is already maximally expressed in nonstressful light conditions and encodes a protein required for efficient light responses and growth. LHCX1 also influences natural variability in photoresponse, as evidenced in ecotypes isolated from different latitudes that display different LHCX1 protein levels. We conclude, therefore, that this gene plays a pivotal role in managing light responses in diatoms.
A CMOS BEOL accelerometer low-noise readout amplifier with 4.2 zF/√Hz total noise floor

This article describes a low-noise readout amplifier for a post-CMOS BEOL (Back End Of Line) surface micromachining capacitive accelerometer. Simulations show 300.0 zF/√Hz acceleration and 4.2 zF/√Hz capacitance noise floors while chopping at 1 MHz and having a power consumption of 1.38 mW. The performed noise minimization is described, comprising input transistor pair type election, optimum input pair inversion region and dimensions using an all-region EKV model and equations describing parasitics and loop characteristics of the circuit. Simulations have been included that verify the theoretical model accuracy and demonstrate final circuit noise performance. The circuit layout has been taped out and testchip availability is expected soon for experimental measurements.
A New Printed Slot Loop Antenna With Tunable Strips for 2.4- and 5-GHz Wireless Applications

This letter presents a new printed slot loop antenna with a pair of tunable strips for wireless communication systems in 2.4-GHz (2.40-2.48 GHz) and 5-GHz (5.15-5.95 GHz) bands. If a pair of the strips is inset at the center of the slot loop antenna, then the resulting impedance bandwidth for the two main operating bands can reach about 100 MHz for the 2.4-GHz band, and 1550 MHz for the 5-GHz band, thus covering the required operations of a wireless local area network (WLAN). Experimental results confirm in detail several properties of the proposed antenna design, such as the impedance bandwidth, radiation pattern and measured gain.
Identifying Social Network Effects

This paper reviews the current state of empirical econometric identification in the economics of networks. Possible identification strategies which exploit the properties and characteristics of networks are described. The main arguments are illustrated with examples from the US AddHealth data and an account of the Bloomsbury Group network. Prescriptive suggestions, based on the way in which networks actually form and operate, are made for a more considered approach to empirical econometric work which involve networks.
Prognostic Classification of Malignant Melanomas by Combining Clinical, Histological, and Immunohistochemical Parameters

In a retrospective study the prognostic relevance of clinical, histopathological, immunohistochemical, and flow-cytometric parameters in primary malignant melanomas was evaluated using both the receiver operating characteristic ROC procedure and the logistic regression model. The proteolytic enzymes collagenase IV, cathepsin B, and cathepsin D proved to be significant prognostic factors. Combining the results obtained with these enzymes with gender, anatomic site, tumour thickness, Clark’s level, ulceration, pattern of invasive growth, and presence of large round cells resulted in greatly improved discrimination between metastasized and non-metastasized cases. It is anticipated that this method could allow for precise individual prognostic characterization and in particular for identification of high-risk patients for adjuvant therapy.
Postoperative cerebrovascular accidents in general surgery

In a prospective study of postoperative complications, strokes occurred in 6 out of 2463 patients (0.2%) who underwent non‐cardiac, non‐carotid artery surgery. The patients who experienced cerebrovascular accidents, including three cases of transient ischemic attack, were significantly older than the rest of the group (mean age 79 years versus 65 years) and had manifestations of atherosclerosis in at least one organ preoperatively. Significant predictors of risk for postoperative cerebrovascular accidents were previous cerebrovascular disease, heart disease, peripheral vascular disease, and hypertension. Cerebrovascular accidents occurred late in the postoperative period, 5–26 days after surgery, and were not directly related to surgery and anesthesia. They were more frequent after acute than after elective operations. Precipitating factors for some of the stroke incidents were rapid atrial fibrillation and postoperative dehydration.
To Tell or Not to Tell? Professional and Lay Perspectives on the Disclosure of Personal Health Information in Community-Based Dementia Care*

ABSTRACT Developments in information technology and the ongoing restructuring of health services to increase provision in community settings militate in favour of a streamlining of communications and the exchange of information about patients among health and social care providers. Yet the principles of confidentiality and privacy appear to inhibit this process. In order to explore the practical, ethical, and legal imperatives attendant upon personal health information exchange, we conducted a series of interviews with professional care providers, persons with early-stage dementia, and their family caregivers. The findings indicate some degree of discordance. Professionals reported valuing disclosure both to colleagues and family caregivers on the basis of its being in the patients' best interests. Patients also valued inter-professional exchange, but sought strong control over disclosure to family members. Family caregivers valued being kept informed of the patient's condition, even without the latter's consent. Implications for research and policy are discussed. RÉSUMÉ Les développements en technologie informatique et la restructuration constante des services de santé en vue d'accroître les services en communauté plaident en faveur d'une amélioration des communications et l'échange d'information personnelle des patients entre les divers fournisseurs de soins sociaux et de la santé. Cependant, les principes de confidentialité et de protection de la vie privée sembleraient empêcher ces processus. Afin d'explorer les obligations pratiques, éthiques et légales qui relèvent des échanges d'information personnelle de santé, nous avons mené une série d'entrevues avec des intervenants en milieu de la santé, des personnes au stage initial de la démence ainsi qu'avec des aidants naturels. Les résultats indiquent qu'un certain niveau de discorde règne parmi les principaux concernés. Les professionnels de la santé indiquent qu'ils approuvent le dévoilement d'information à leurs collègues et aux aidants naturels dans l'intérêt des patients. Les patients reconnaissent les avantages de la divulgation d'information personnelle aux intervenants professionnels, mais ils préféreraient retenir le contrôle du dévoilement aux membres de la famille. Quant aux membres de la famille, ils souhaitent être informés de la condition du patient, et ce, même sans son accord. Le présent travail discute aussi les implications de ces résultats pour la recherche et la formation de nouvelles politiques.
Cognitive assessment for CI therapy in the outpatient clinic.

OBJECTIVE To evaluate in a preliminary fashion whether several standard cognitive assessments predict treatment outcomes on real-world functional activities following Constraint-Induced Movement therapy (CI therapy) for either the upper extremity (UE) or the lower extremity (LE) for chronic stroke hemiparesis in the outpatient therapy clinic. METHODS 15 UE and 14 LE patients in the clinic underwent a short battery of cognitive assessments that evaluated sustained attention, episodic memory, executive control abilities, and general cognitive function. Spearman correlation analysis was used to evaluate whether each cognitive test predicted treatment outcome on the limb-specific Motor Activity Log (MAL). RESULTS Two assessments (delayed verbal memory and Trail Making Test form B) significantly correlated with LE MAL change that followed therapy. CONCLUSIONS We tentatively conclude from this exploratory and preliminary study that cognitive performance may predict treatment changes in response to CI therapy for the LE. Moderate to large correlations that we observed between other cognitive assessments and CI therapy outcomes recommend replicating this study with a larger and more cognitively diverse sample of stroke patients to learn if these findings are generalizable.
Progress in understanding and managing natural killer‐cell malignancies

The World Health Organization classification of haematolymphoid tumours recognizes three categories of natural killer (NK)‐cell neoplasms: blastic NK‐cell lymphoma, aggressive NK‐cell leukaemia, and extranodal NK/T‐cell lymphoma, nasal‐type. Recent studies indicate that CD4+CD56+ blastic NK‐cell lymphoma is of plasmacytoid dendritic cell origin, and true tumours of precursor NK‐cell origin may be present mainly in the CD4−CD56+ subset. Myeloid/NK‐cell precursor acute leukaemia may also develop from precursor NK cells. However, because the developmental pathway of normal NK cells is not well understood, tumours of precursor NK‐cell origin are not clearly identified. Among mature NK‐cell tumours, extranodal NK/T‐cell lymphoma is relatively common in Asia and Latin America. In localized disease, chemoradiotherapy seems to be promising, and in advanced disease, new combination chemotherapies are under active investigation. Aggressive NK‐cell leukaemia is rare and has a poor prognosis. Because NK‐cell neoplasms are rare and difficult to manage, rigorous studies are required for their understanding and management.
Acute kidney injury and outcomes in acute decompensated heart failure: evaluation of the RIFLE criteria in an acutely ill heart failure population

The clinical course including the outcome of acute decompensated heart failure (ADHF) correlates with renal dysfunction, but the evaluation of renal function has not yet been standardized. We therefore investigated the relationship between the prognosis of ADHF and acute kidney injury (AKI) evaluated using the risk, injury, failure, loss, end stage (RIFLE) criteria.
Having to Fight

Existing research that attempts to understand aggressive behavior often focuses on adults and/or individual traits. The present study used a Grounded Theory approach to develop a theoretical framework of how younger adolescents constructed an understanding of their own aggressive behavior within the social context of their lives. The participants were 11 adolescents (aged 12-16) who had previously been involved in incidents of aggression at a school for children with emotional and behavioral difficulties. The identified theoretical framework outlined that aggressive behavior was fundamental to an identity of toughness that participants sought to portray to others. This identity emerged in a hostile peer environment to prevent victimization and establish friendships. The findings are discussed in relation to their clinical implications, limitations, and possibilities for further research.
An example of low-medium income working women in Mexico City: How can their vision reshape transport policy?

1 This paper focuses on mobility and accessibility in Mexico City especially for low-medium 2 income working women using a qualitative approach. Through in-depth interviews, we discuss 3 different mobility and transport issues to understand what the main factors that influence their 4 travel patterns are, how the different services are perceived and evaluated, and what their dairy 5 constraints are. Our final aim is to understand what is still missing and to discuss the following 6 steps regarding transport policy in Mexico City and its Metropolitan area through a gender 7 perspective. Interestingly, even if there are important gender issues raised by participants, they 8 have assumed these issues as being part of their daily life, modifying their transport patterns 9 accordingly. They also perceive that there are many problems which concern the transport 10 system in general, others related to the complexity of the metropolis and the lack of civic11 mindedness. The results also show a huge gap between women’s needs, depending on their 12 income and place of residence. 13 14
Entrepreneurial Motivation and Business Performance of SMEs in the SUCI Clothing Center, Bandung, Indonesia

There is a gap in entrepreneurial motivation between psychological and external environment approach. In order to assess the relative importance of that gap, this study examined the entrepreneurial motivation, which defines both psychological variable and external environment, by measuring business performance level in Suci clothing center, Bandung. This study is valuable considering the limited number of empirical works previously done on the topic in question. Research method being used was multiple regression analysis. Purposive sampling was performed to 94 respondents which are owners of the small and medium-sized enterprises (SMEs) in Suci clothing center, Bandung. The findings of this research show that entrepreneurial motivation potential simultaneously and partially have a significant influence to SMEs’ business performance and the most dominant influential effect is self-efficacy while achievement has the least dominant influential effect.
Psychological reactions to terrorist attacks: findings from the National Study of Americans' Reactions to September 11.

CONTEXT The terrorist attacks of September 11, 2001, represent an unprecedented exposure to trauma in the United States. OBJECTIVES To assess psychological symptom levels in the United States following the events of September 11 and to examine the association between postattack symptoms and a variety of indices of exposure to the events. DESIGN Web-based epidemiological survey of a nationally representative cross-sectional sample using the Posttraumatic Stress Disorder (PTSD) Checklist and the Brief Symptom Inventory, administered 1 to 2 months following the attacks. SETTING AND PARTICIPANTS Sample of 2273 adults, including oversamples of the New York, NY, and Washington, DC, metropolitan areas. MAIN OUTCOME MEASURES Self-reports of the symptoms of PTSD and of clinically significant nonspecific psychological distress; adult reports of symptoms of distress among children living in their households. RESULTS The prevalence of probable PTSD was significantly higher in the New York City metropolitan area (11.2%) than in Washington, DC (2.7%), other major metropolitan areas (3.6%), and the rest of the country (4.0%). A broader measure of clinically significant psychological distress suggests that overall distress levels across the country, however, were within expected ranges for a general community sample. In multivariate models, sex, age, direct exposure to the attacks, and the amount of time spent viewing TV coverage of the attacks on September 11 and the few days afterward were associated with PTSD symptom levels; sex, the number of hours of television coverage viewed, and an index of the content of that coverage were associated with the broader distress measure. More than 60% of adults in New York City households with children reported that 1 or more children were upset by the attacks. CONCLUSIONS One to 2 months following the events of September 11, probable PTSD was associated with direct exposure to the terrorist attacks among adults, and the prevalence in the New York City metropolitan area was substantially higher than elsewhere in the country. However, overall distress levels in the country were within normal ranges. Further research should document the course of symptoms and recovery among adults following exposure to the events of September 11 and further specify the types and severity of distress in children.
SUPPORT VECTOR MACHINES FOR AUTOMATIC DETECTION OF TUBERCULOSIS BACTERIA IN CONFOCAL MICROSCOPY IMAGES

This paper presents an image segmentation method based on support vector machines classifiers at a pixel level. We apply this method to quantify the amount of Mycobacterium tuberculosis in confocal microscopy images for drug-discovery within the context of high content screening (HCS). To deal with the performance constraints of HCS, we propose a model-selection algorithm that finds the best classifier's hyperparameters by optimizing both classification rate and complexity. We validate our HCS adapted approach against commonly used readout techniques
Effects of fixatives on function of pulmonary surfactant.

The structure of pulmonary surfactant films remains ill defined. Although plausible film fragments have been imaged by electron microscopy, questions about the significance of the findings and even about the true fixability of surfactant films by the usual fixatives glutaraldehyde (GA), osmium tetroxide (OsO(4)), and uranyl acetate (UA) have not been settled. We exposed functioning natural surfactant films to fixatives within a captive bubble surfactometer and analyzed the effect of fixatives on surfactant function. The capacity of surfactant to reach near-zero minimum surface tension on film compression was barely impaired after exposure to GA or OsO(4). Although neither GA nor OsO(4) prevented the surfactant from forming a surface active film, GA increased the equilibrium surface tension to above 30 mN/m, and both GA and OsO(4) decreased film stability as seen in the slowly rising minimum surface tension from 1 to ~5 mN/m in 10 min. In contrast, the effect of UA seriously impaired surface activity in that both adsorption and minimum surface tension were substantially increased. In conclusion, the fixatives tested in this study are not suitable to fix, i.e., to solidify, surfactant films. Evidently, however, OsO(4) and UA may serve as staining agents.
The contributions of filaments and cross‐bridges to sarcomere compliance in skeletal muscle

Muscle contraction is driven at the molecular level by a structural working stroke in the head domain of the myosin cross‐bridge linking the thick and thin filaments. Crystallographic models suggest that the working stroke corresponds to a relative movement of 11 nm between the attachments of the head domain to the thin and thick filaments. The molecular mechanism of force generation depends on the relationship between cross‐bridge force and movement, which is determined by cross‐bridge and filament compliances. Here we measured the compliance of the cross‐bridges and of the thin and thick filaments by combining mechanical and X‐ray diffraction experiments. The results show that cross‐bridge compliance is relatively low and fully accounted for by the elasticity of the myosin head, suggesting that the myosin cross‐bridge generates isometric force by a small sub‐step of the 11 nm stroke that drives filament sliding at low load.
Surgical Management of Hyperparathyroidism

Hyperparathyroidism is a single-gland disease in 80-907% of cases. About one-half of the patients surgically treated are asymptomatic, but the risk of complications is great enough to justify cervical exploration in most cases. Using knowledge of embryology and anatomy for exploration of the parathyroid glands the surgeon can locate the pathological tissue in 95%10 of cases without the use of sophisticated tests. Once the disease has been treated the recurrence rate of hypercalcaemia is no more than ilo. When hyperplasia is the underlying pathological condition subtotal parathyroidectomy, or resection of 31 glands, is indicated. Every attempt should be made to reduce the incidence of permanent hypocalcaemia as a complication of treatment and to keep surgical mortality near zero.
Epsilon Protein Kinase C Mediated Ischemic Tolerance Requires Activation of the Extracellular Regulated Kinase Pathway in the Organotypic Hippocampal Slice

Ischemic preconditioning (IPC) promotes brain tolerance against subsequent ischemic insults. Using the organotypic hippocampal slice culture, we conducted the present study to investigate (1) the role of adenosine A1 receptor (A1AR) activation in IPC induction, (2) whether epsilon protein kinase C (ɛPKC) activation after IPC is mediated by the phosphoinositol pathway, and (3) whether ɛPKC protection is mediated by the extracellular signal-regulated kinase (ERK) pathway. Our results demonstrate that activation of A1AR emulated IPC, whereas blockade of the A1AR during IPC diminished neuroprotection. The neuroprotection promoted by the A1AR was also reduced by the ɛPKC antagonist. To determine whether ɛPKC activation in IPC and A1AR preconditioning is mediated by activation of the phosphoinositol pathway, we incubated slices undergoing IPC or adenosine treatment with a phosphoinositol phospholipase C inhibitor. In both cases, preconditioning neuroprotection was significantly attenuated. To further characterize the subsequent signal transduction pathway that ensues after ɛPKC activation, mitogen-activated protein kinase kinase was blocked during IPC and pharmacologic preconditioning (PPC) (with ɛPKC, NMDA, or A1AR agonists). This treatment significantly attenuated IPC- and PPC-induced neuroprotection. In conclusion, we demonstrate that ɛPKC activation after IPC/PPC is essential for neuroprotection against oxygen/glucose deprivation in organotypic slice cultures and that the ERK pathway is downstream to ɛPKC.
Three Questions on R-star

The decline in the natural rate of interest, or r-star, over the past decade raises three important questions. First, is this low level for the real short-term interest rate unique to the U.S. economy? Second, is the natural rate likely to remain low in the future? And third, is this low level confined to “safe” assets? In answer to these questions, evidence suggests that low r-star is a global phenomenon, is likely to be very persistent, and is not confined only to safe assets.