Miracle-dz/UniFAR-FTUs huggingface dataset:
Metaheurísticas en localización: análisis teórico y experimental

EN LA MEMORIA QUE CONSTA DE TRES CAPITULOS Y CUATRO APENDICES, SE REALIZA UN ANALISIS TEORICO Y EXPERIMENTAL DE VARIOS METAHEURISTICOS CUANDO SE APLICAN A LA RESOLUCION DE DIFERENTES PROBLEMAS DE LOCALIZACION, EN EL CAPITULO 1 SE ENCUENTRA UNA DESCRIPCION DE LOS PROBLEMAS DE LOCALIZACION CONSIDERADOS. EN EL CAPITULO 2, SE PROPONEN UNA NUEVA CODIFICACION, UNA FUNCION DE SELECCION Y UNOS OPERADORES GENETICOS PARA LOS PROBLEMAS DE LOCALIZACION CONSIDERADOS. USANDO ESTAS PROPUESTAS SE REALIZA UN ESTUDIO TEORICO DE LOS NIVELES DE EXPLORACION Y EXPLOTACION DEL ALGORITMO. ADEMAS, SE ANALIZA LA INFLUENCIA QUE TIENE SOBRE LA CALIDAD DE LA SOLUCION PROPUESTA LOS DIFERENTES PARAMETROS QUE INTERVIENEN EN LA DESCRIPCION DEL ALGORITMO. EN EL CAPITULO 3 SE REALIZA UN ANALISIS DEL EFECTO QUE TIENE SOBRE LA CALIDAD DE LA SOLUCION PROPUESTA LA ELECCION DE NUEVAS ALTERNATIVAS PARA LOS ELEMENTOS QUE DETERMINAN COMPLETAMENTE UN METODO MULTIARRANQUE. ASIMISMO, SE ADAPTAN Y DESARROLLAN NUEVAS REGLAS DE PARADA ANALIZANDO EL NUMERO DE ITERACIONES NECESARIAS HASTA ENCONTRAR EL OPTIMO Y EL NUMERO DE MINIMOS.
Consequences of Trisomy 16 for Mouse Brain Development: Corticogenesis in a Model of Down Syndrome

We have studied abnormalities in the tangential and radial expansion of the cerebral cortex during fetal development in the trisomy 16 (Ts16) mouse, a model for human trisomy 21 (Down syndrome). Slowed tangential expansion of the neuroepithelium in Ts16 resulted in a reduction of final telencephalic size and is predicted to decrease the number of radial cortical units in the mature brain. In addition, radial growth of the Ts16 cortex was delayed at the time of peak cortical neurogenesis in normal mice, but by embryonic day 18 the cortex reached normal thickness. Because mouse chromosome 16 shares many genes with human chromosome 21, abnormalities in Ts16 brain development may parallel abnormalities in trisomy 21.
Beyond Access Control: Managing Online Privacy via Exposure

We posit that access control, the dominant model for modeling and managing privacy in today’s online world, is fundamentally inadequate. First, with access control, users must a priori specify precisely who can or cannot access information by enumerating users, groups, or roles—a task that is difficult to get right. Second, access control fails to separate who can access information from who actually does, because it ignores the difficulty of finding information. Third, access control does not capture if and how a person who has access to some information redistributes that information. Fourth, access control fails to account for information that can be inferred from other, public information. We present exposure as an alternate model for information privacy; exposure captures the set of people expected to learn an item of information eventually. We believe the model takes an important step towards enabling users to model and control their privacy effectively.
Development of Key Performance Indicators for Rehabilitation, Murrin Murrin Nickel Operation

The Murrin Murrin Nickel Cobalt Project (Project) which is owned by subsidiaries of Minara Resources Limited and Glencore International AG and operated by Murrin Murrin Operations Pty Ltd (MMO), is located approximately 60 km east of Leonora in the North Eastern Goldfields of Western Australia. The Project includes open cut pits from which nickel laterite ore is mined using conventional open cut techniques and a processing plant which uses High Pressure Acid Leach (HPAL) technology to extract and recover the nickel and cobalt from the ore. Over the life of the mine, approximately 2500 ha of waste dumps are expected to be constructed. Progressive rehabilitation of disturbed areas was committed to by MMO when it obtained Project approval. Based on current guidelines provided by the WA Department of Industry and Resources (DoIR), MMO is required to post an Environmental Performance Bond (Bond) on various areas disturbed by mining operations. Currently, for waste dumps, the rate is typically set at $10000 per hectare (DME, 2003). If Bonds simply accumulated over the life of the MMO, waste dumps alone would represent a bond requirement of $25,000,000. As Bonds (at differing rates) are also required for other areas of disturbance on the site, the potential total bond for MMO by completion of mining could be extremely large indeed. If no rehabilitation was done until completion of mining, MMO would not only have significant funds committed to performance bonds, but would then also need to provide a similar level of funding to carry out rehabilitation of the areas of disturbance. Funding that level of bonding plus rehabilitation requirements would create a considerable challenge for any company, illustrating that a commitment to progressive rehabilitation is both environmentally and economically responsible. Current DoIR guidelines for Bonds allow for their progressive return on the basis of rehabilitation progress (Table 1), providing a strong economic incentive for the site to carry out progressive rehabilitation during the life of the mine and keep commitments to Bonds to as low a level as possible. However, that strategy faces two challenges. The first is to achieve stable and sustainable rehabilitation reliably and cost-effectively. The second is to establish an effective process for the assessment of rehabilitation success and the progressive return of Bonds on the basis of that assessment. This paper describes the way in which MMO has dealt with both those challenges. Mine Closure 2006 ― Andy Fourie and Mark Tibbett (eds) © 2006 Australian Centre for Geomechanics, Perth, ISBN 0-9756756-6-4 Mine Closure 2006, Perth, Australia 569 Table 1 Suggested levels of Environmental Performance Bond reduction (DME 2003) Stage Action Completion Criteria Met Reduce bond to $/ha
Morphology and valence band offset of GaSb quantum dots grown on GaP(001) and their evolution upon capping

This work presents a detailed study of GaSb quantum dot (QD) epitaxy on (001) GaP substrates by means of molecular beam epitaxy. Despite the large mismatch between GaP and GaSb, we show that in the nucleation–diffusion regime, the QD size distribution follows the predictions of the scaling theory. Scanning transmission electron microscopy analysis of grown QDs reveal that they are plastically relaxed by 60° pairs of misfit dislocations and the valence band offset measured by x-ray photoelectron spectroscopy on such QDs amounts to 0.5 eV. After capping, the QD morphology is strongly modified with a large P/Sb exchange–segregation reaction, which even leads to the formation of core–shell nanostructures. Remarkably the resulting QD layer is coherent to the substrate without any remaining misfit dislocation and exhibits still strong composition modulations.
Integrated design and control applied to a buck boost converter

Frequently, the design of many processes or systems is performed without taking into account its dynamical behaviour. This leads to lost of performance when the process has to operate dynamically, as the design may impose constraints in the physically reachable dynamic. The joint design of equipment and its control system is an integration technique that incorporates control requirements in the process design stage. This paper illustrates the technique with a buck boost converter. The design has been performed including its control system and it is not only optimum from the point of view of the cost of its components, but it is also a system that complies with certain previously fixed dynamic characteristics.
Defining PET tumor volume in cervical cancer with hybrid PET/MRI: a comparative study

ObjectiveThe aim of the study was to determine the standardized uptake value (SUV) threshold on gross tumor volume from PET images (PET-GTV) that generates the maximal spatial overlap with MRI-defined GTV (MR-GTV) in locally advanced cervical cancer with the aid of hybrid PET/MRI. Materials and methodsTwenty-seven patients with cervical carcinomas underwent 18F-FDG PET/MRI before radiotherapy. MR-GTV was manually outlined on T2-weighted MRI. PET-GTVs were contoured on PET images using visual inspection (PETvis-GTV), 2.5 SUV (PET2.5-GTV) and 40% SUVmax threshold (PET40-GTV), and compared with MR-GTV. All PET data were reviewed again. The PET-GTV was determined, with the SUVmax threshold defined as the value at which the Dice similarity coefficient (DSC) between PET-GTV and MR-GTV was maximal (PETdsc-GTV). Results were analyzed by Pearson’s analysis, the t-test, and one-way analysis of variance. ResultsThe mean PETvis-GTV, PET40-GTV, and PET2.5-GTV were significantly different from the mean MR-GTV. The average DSCs were 0.64, 0.65, and 0.68 for PETvis-GTV, PET40-GTV, and PET2.5-GTV with MR-GTV, respectively. The mean threshold of PETdsc-GTV was 29.4% SUVmax, with a maximal DSC value of 0.72 in all patients. PET-GTVs as defined by thresholds of 25 and 30% of SUVmax were not statistically different from the MR-GTV. The mean thresholds of PETdsc-GTV were 43.3±8.8, 27.9±5.8, and 22.2±2.6% for MR-GTV<14, 14–62, and ≥62 cm3, respectively. ConclusionPETvis-GTV, PET2.5-GTV, and PET40-GTV do not appear to be suitable for target volume delineation in locally advanced cervical cancer. The PETdsc-GTV may increase the accuracy in target volume delineation. Furthermore, a high level of tumor overlap existed between MR-GTV and PETdsc-GTV in hybrid PET/MRI.
Characterization of downy mildew isolates of Sclerospora graminicola by using differential cultivars and molecular markers.

Fourteen differential cultivar sets were used to analyze 27 downy mildew isolates of pearl millet, Sclerospora graminicola from different agroclimatic regions of India. Among 27 isolates, six distinct pathotypes were determined, the isolates were found to infect a narrow range of differential cultivars used and the disease incidence ranged between 0-98 per cent. Comparisons of RAPD and ISSR marker analyses were carried out on six S. graminicola pathotypes. A total of 20 random and 19 ISSR primers generated 152 and 297 bands and revealed 73.6 and 82.15% polymorphism which were able to distinguish the six pathotypes. In RAPD, maximum genetic distance index obtained was 0.1312 between pathotype-2 and pathotype-3 and minimum distance of 0.0231 was between pathotype-1 and pathotype-4. In ISSR 0.1302 was maximum between pathotype-4 and pathotype-6 and minimum distance was 0.0124 from pathotype-1 and pathotype-5. UPGMA dendrograms obtained from cluster analysis data gave similarity coefficient ranging from 0.27 to 0.88 and 0.40 to 0.83 in RAPD and ISSR, respectively. Clustering of six pathotypes within groups was not similar when RAPD and ISSR derived dendrograms were compared. RAPD and ISSR 3D scaling of ordination supported the UPGMA results and clarified relationships among six S. graminicola pathotypes.
Intuitive decision - making and leadership competencies of managers in Slovenian automotive industry

Research question (RQ): Presence of intuitive decision-making by top and middle managers in Slovenian automotive industry. Purpose: Establish the presence of inuitive decision-making by top and middle managers in Slovenian automotive industry, define the intuitive decision-making with variables of leadership competencies. Methodology: empirical research was conducted within the quantitative research approach by means of a GDMS questionnaire (General Decision Making Style). The obtained research data were processed by means of descriptive statistics, factor analysis (PAF, varimax), recoding and discriminant analysis. Results: Intuitive decision-making by top and middle managers in automotive industry can be characterized by their ability to recognize emotions, to reflect on options when making a decision and by making a decision at the last moment. Organization: Practical (applicable) added value in the area of management personnel administration in the automotive industry and others. Society: Basic starting points set for further detailed and targeted research in other related social areas. Originality: Originality of the conducted research consists in the fact that no available domestic or foreign scientific literature features any research implying the elements of the operationalization applied (examination of relationship between leadership competencies and intuitive decisionmaking) as this is the case in the present research which undoubtedly confirms its originality. Limitations/further research: (1) Use of standardized measuring instruments of foreign origin and potential differences between the environment where the measuring instrumnets were conceived and the environment where they were used. (2) Limited capabilities of translation of measuring instruments into words, collocations and phrases from the original questionnaires for which no adequate translation in Slovene exists.
Cochrane Review on the Role of Surgery in Cervical Spondylotic Radiculomyelopathy

Study Design. This study involved a search of MEDLINE (1966 to 2000), EMBASE (1980 to 2000), and the Cochrane Controlled Trials Register. The authors of the identified randomized controlled trials were contacted to detect any additional published or unpublished data. The trials selected for this study included all the truly unconfounded or quasi-randomized controlled investigations allocating patients with cervical radiculopathy or myelopathy to 1) “best medical management” or “decompressive surgery (with or without some form of fusion) plus best medical management,” or 2) “early decompressive surgery” or “delayed decompressive surgery. ” Two reviewers independently selected trials for inclusion, assessed trial quality, and extracted the data. Objectives. To determine whether surgical treatment of cervical radiculopathy or myelopathy is associated with improved outcome, as compared with conservative management, and whether the timing of surgery (immediate or delayed because of persistence or progression of relevant symptoms and signs) has an impact on outcome. Summary of Background Data. Cervical spondylosis causes pain and disability by compressing the spinal cord or roots. Surgery to relieve the compression may reduce the pain and disability. However, it is associated with a small but definite risk. This study sought to assess the balance of risk and benefit from surgery. Methods. Two trials involving a total of 130 patients were included. One trial with 81 patients compared surgical decompression with either physiotherapy or cervical collar immobilization in patients with cervical radiculopathy. Results. The short-term effects of surgery, in terms of pain, weakness, or sensory loss were superior. However, at 1 year no significant differences between the groups were observed. Another trial with 49 patients compared the effects of surgery with those of conservative treatment in patients who had a mild functional deficit associated with cervical myelopathy. No significant differences were observed between the groups up to 2 years after treatment. Conclusions. The data from the reviewed trials were inadequate to provide reliable conclusions on the balance of risk and benefit from cervical spine surgery for spondylotic radiculopathy or myelopathy.
Improving prediction of helix–helix packing in membrane proteins using predicted contact numbers as restraints

One of the challenging problems in tertiary structure prediction of helical membrane proteins (HMPs) is the determination of rotation of α‐helices around the helix normal. Incorrect prediction of helix rotations substantially disrupts native residue–residue contacts while inducing only a relatively small effect on the overall fold. We previously developed a method for predicting residue contact numbers (CNs), which measure the local packing density of residues within the protein tertiary structure. In this study, we tested the idea of incorporating predicted CNs as restraints to guide the sampling of helix rotation. For a benchmark set of 15 HMPs with simple to rather complicated folds, the average contact recovery (CR) of best‐sampled models was improved for all targets, the likelihood of sampling models with CR greater than 20% was increased for 13 targets, and the average RMSD100 of best‐sampled models was improved for 12 targets. This study demonstrated that explicit incorporation of CNs as restraints improves the prediction of helix–helix packing. Proteins 2017; 85:1212–1221. © 2017 Wiley Periodicals, Inc.
Does Public Ownership and Accountability Increase Diversity?: Evidence From IPOs

Does public ownership improve employment diversity? Organizational researchers theorize that increased transparency to regulators and the public should lead firms to conform to legal and social norms; but also that social closure and decoupling should preserve the status quo. Empirical research has been difficult because we lack data on comparable private firms and because firms likely self-select into going public. We construct a new, nationally representative dataset that links firms' filings for initial public offerings to longitudinal data on employment composition from the Equal Employment Opportunity Commission. We construct a set of comparable firms by looking at companies that filed and then withdrew a plan for an IPO. To account for selection bias in withdrawal and IPO success, we instrument the transition to public ownership using market returns in the book-building phase of the firms' IPO attempts. We find no evidence that moving from private to public ownership increases the representation of women or nonwhite workers or managers. We discuss the implications of this finding for our ability to generalize findings in organizational research.
The role of environmental CSR practices on the formation of behavioral intentions in a certified hotel context

Purpose This study aims to explore the relationships among green practices, environmental corporate social responsibility (CSR) image, customers’ trust and their behavioral intentions in a certified hotel context and examine the moderating effect of customers’ involvement in the buying process. Design/methodology/approach A survey was used to collect data from Spanish hotel customers. A structural equation model was developed to assess the research hypotheses. Findings Consumers’ trust on environmentally certified hotels has a direct effect on their behavioral intentions. Environmental CSR image has a direct effect on consumers’ trust on environmentally certified hotels, but it does not exert significant influence on consumers’ behavioral intentions. Additionally, the results support a positive and significant influence of consumers’ perceptions of green practices on the environmental CSR image of hotels. Finally, there is not a moderating effect of consumers’ involvement on the effects of green practices on CSR environmental image and of this variable on behavioral intentions. Research limitations/implications To cross validate the results of this study, it is recommended that the formation of behavioral intentions in various types of environmentally certified hotel settings be investigated in future research. Practical implications Hospitality managers should design strategies to raise the perception of the green-related features of environmentally certified companies. Originality/value No prior study investigates the relationship between green practices, customers’ trust, their degree of involvement in the buying process and their behavioral intentions in relation to companies’ environmental CSR image in the hotel sector.
Repertoire of SSRs in the Castor Bean Genome and Their Utilization in Genetic Diversity Analysis in Jatropha curcas

Castor bean and Jatropha contain seed oil of industrial importance, share taxonomical and biochemical similarities, which can be explored for identifying SSRs in the whole genome sequence of castor bean and utilized in Jatropha curcas. Whole genome analysis of castor bean identified 5,80,986 SSRs with a frequency of 1 per 680 bp. Genomic distribution of SSRs revealed that 27% were present in the non-genic region whereas 73% were also present in the putative genic regions with 26% in 5′UTRs, 25% in introns, 16% in 3′UTRs and 6% in the exons. Dinucleotide repeats were more frequent in introns, 5′UTRs and 3′UTRs whereas trinucleotide repeats were predominant in the exons. The transferability of randomly selected 302 SSRs, from castor bean to 49 J. curcas genotypes and 8 Jatropha species other than J. curcas, showed that 211 (∼70%) amplified on Jatropha out of which 7.58% showed polymorphisms in J. curcas genotypes and 12.32% in Jatropha species. The higher rate of transferability of SSR markers from castor bean to Jatropha coupled with a good level of PIC (polymorphic information content) value (0.2 in J. curcas genotypes and 0.6 in Jatropha species) suggested that SSRs would be useful in germplasm analysis, linkage mapping, diversity studies and phylogenetic relationships, and so forth, in J. curcas as well as other Jatropha species.
Risk factors for abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis: A hospital based-cohort study

Abstract Objectives: Methotrexate (MTX) is used as first-line treatment of rheumatoid arthritis (RA) worldwide. Large interindividual differences in MTX effectiveness and safety occur, and the most frequent adverse reaction is hepatotoxicity, although the main cause remains unknown. We investigated factors associated with MTX-induced hepatic enzyme elevation in a hospital-based cohort study. Methods: Study participants were 114 Japanese adult RA outpatients prescribed MTX. Sixteen types of single-nucleotide polymorphisms were investigated using real-time PCR. Patient characteristics were collected from the electronic medical records. The onset of MTX-induced abnormal hepatic enzyme elevation was defined according to deviation from normal liver enzyme reference values during treatment. The observation period was 1 year after beginning MTX. Associations between MTX-induced hepatic enzyme elevation and patient characteristics were evaluated using the multivariate logistic regression model. Results: Thirty-two patients experienced MTX-induced abnormal hepatic enzyme elevation. In multivariate analysis, MTX dosage, estimated glomerular filtration rate (eGFR), and genetic polymorphisms of ABCB1 3435C>T and ATIC 347C>G were associated with abnormal hepatic enzyme elevation. Conclusions: MTX-induced abnormal hepatic enzyme elevation in Japanese RA patients was associated with dosage and eGFR as nongenetic factors, and with ABCB1 3435C>T and ATIC 347C>G as genetic factors in this hospital-based cohort study.