Miracle-dz/UniFAR-FTUs huggingface dataset:
Resilience in the modern career

Purpose – Career resilience (CR) is an increasingly important, but under-researched aspect of modern careers. The purpose of this paper is to examine the mediating effect of CR on the relationships between personality factors, career self-evaluations and modern career orientation and the outcome of career satisfaction (CS). The authors hypothesized that CR would be positively associated with the “big-5” personality factors, career self-evaluations (self-efficacy and external locus of control) and modern career orientations (protean and boundaryless orientations) and that CR would mediate those variables’ relationships with CS. Design/methodology/approach – The participants in the study were 1,988 employed managers and professionals. Structural equation modeling was used to test the proposed relationships and mediation model. Findings – CR mediated the relationships between CS and emotional stability, conscientiousness, emotional stability, openness to experience, internal work locus of control, career sel.
Experimental comparison of hard-switching, ZVT and SiC inverters

Various soft switching inverter topologies have been reported in the literature with the aims of reducing the switching losses and dynamic switching stress. However, lower losses are generally regarded as one of the most significant advantages of the emerging silicon carbide semiconductor devices over the conventional silicon devices. Both routes seem viable to improve the converter efficiency. To investigate the optimal solution, this paper experimentally evaluates the efficiency of six prototypes, i.e., three zero-voltage transition inverters differing only in the power switches, and three hard-switching inverters, mounting both silicon and silicon carbide devices. A set of experimental results is included.
A Normalized Weighted RMSD for Measuring Protein Structure Superposition

Root-mean-square-deviation (RMSD) is the most widely used measure of the similarity of superimposed protein structures, but it is sensitive to outliers and a smaller RMSD value may not correspond to a better structure superposition. Many alternative measures have been proposed to overcome the deficiency in RMSD. In this paper, we extend the RMSD to normalized weighted RMSD (nwRMSD) to measure the quality of superimposed structures, where the nwRMSD assigns a normalized weight to each superimposed position. We present an iterative algorithm to minimize nwRMSD for structure superposition and propose a new weight function for structure superposition. We show that NMR ensembles minimized by the nwRMSD measure can clearly display structurally conserved and flexible regions, which are better than the superposition in original structures.
Combination Therapy of VEGF-Trap and Gemcitabine Results in Improved Anti-Tumor Efficacy in a Mouse Lung Cancer Model

Background Angiogenesis is essential for the growth and metastasis of cancer. Although anti-angiogenic agents, particularly vascular endothelial growth factor (VEGF) inhibitors, have exhibited single-agent activity, there is considerable interest in combining these novel drugs with conventional chemotherapy reagents to achieve an optimal clinical efficacy. The objective of this study was to evaluate the benefits of the combination therapy of vascular endothelial growth factor trap (VEGF-Trap) with gemcitabine in a lung tumor model. Methods A luciferase-expressing Lewis lung carcinoma (LLC) model was established in C57BL/6J mice and tumor-bearing mice were randomized into control, VEGF-Trap, gemcitabine and VEGF-Trap/gemcitabine combination groups. Tumor growth and animal survival were monitored. Tumor microvessel density and cell proliferation were evaluated by CD31 and Ki-67 immunohistochemical analysis. TUNEL assay was performed to detect apoptotic cells. The protein levels of Cyclin D1, Pro-Caspase-3, Bcl-2, MMP2 and MMP9 in tumor extracts were examined by western blot. Results VEGF-Trap in combination with gemcitabine showed significantly enhanced inhibition of tumor growth and prolonged mouse survival compared to the VEGF-Trap or gemcitabine monotherapy. The VEGF-Trap/gemcitabine combination therapy not only potently inhibited tumor angiogenesis and cell proliferation, but also increased cellular apoptosis within tumor tissues. In addition, the combination treatment markedly down-regulated the expression of proliferation, anti-apoptosis and invasion related proteins. Conclusion Combination therapy using VEGF-Trap and gemcitabine resulted in improved anti-tumor efficacy in a lung cancer model and VEGF-Trap/gemcitabine combination might represent a promising strategy in the treatment of human lung cancer.
What Will I Do Next? The Intention from Motion Experiment

In computer vision, video-based approaches have been widely explored for the early classification and the prediction of actions or activities. However, it remains unclear whether this modality (as compared to 3D kinematics) can still be reliable for the prediction of human intentions, defined as the overarching goal embedded in an action sequence. Since the same action can be performed with different intentions, this problem is more challenging but yet affordable as proved by quantitative cognitive studies which exploit the 3D kinematics acquired through motion capture systems.In this paper, we bridge cognitive and computer vision studies, by demonstrating the effectiveness of video-based approaches for the prediction of human intentions. Precisely, we propose Intention from Motion, a new paradigm where, without using any contextual information, we consider instantaneous grasping motor acts involving a bottle in order to forecast why the bottle itself has been reached (to pass it or to place in a box, or to pour or to drink the liquid inside). We process only the grasping onsets casting intention prediction as a classification framework. Leveraging on our multimodal acquisition (3D motion capture data and 2D optical videos), we compare the most commonly used 3D descriptors from cognitive studies with state-of-the-art video-based techniques. Since the two analyses achieve an equivalent performance, we demonstrate that computer vision tools are effective in capturing the kinematics and facing the cognitive problem of human intention prediction.
Interference Channels With Common Information

In this paper, the interference channel with common information (ICC), in which two senders need deliver not only private messages but also certain common messages to their corresponding receivers, is investigated. An achievable rate region for such a channel is obtained by applying a superposition coding scheme that consists of successive encoding and simultaneous decoding. It is shown that the derived achievable rate region includes or extends several existing results for the interference channels with or without common information. The rate region is then specialized to a class of ICCs in which one sender has no private information to transmit, and a class of deterministic interference channels with common information (DICCs). In particular, the derived rate region is found to be the capacity region for this class of DICCs. Last, the achievable rate region derived for the discrete memoryless ICC is extended to the Gaussian case, in which a numerical example is provided to illustrate the improvement of our rate region over an existing result.
Predicting defibrillation outcome based on phase of ventricular activity during ICD implantation

Implantable cardioverter-defibrillaters (ICDs) are well known medical device for patients who are at a risk of sudden cardiac death caused by ventricular fibrillation (VF). The relationship between VF mechanisms and successful ICD therapy to terminate of VF is still not well understood. The purpose of this work is to evaluate the timing of ICD therapy as a predictor of successful VF termination. Clinical data sets were recorded from the patients who underwent ICD implantation in 6 Canadian centers. Timing of the defibrillation attempt (phase) was analyzed by using the ICD Marker Channel which monitors and displays cardiac events sensed by ICD. Phase, based on the VF period, was divided into 10 equally distributed bins and number of successful defibrillation episodes in each bin was compared. A total of 187 defibrillation attempts were identified from the 65 subjects. 126 of the defibrillation attempts were successful, while 61 failed. The optimal case was observed at a phase value of 1. 2π with 2 successful attempts. The lowest performance rate was found at a phase value of 1. 4π and 1. 8π with 50% (3 and 2 successful attempts, respectively). The probability of success was analyzed by using generalized estimating equations (GEE) approach with an exchangeable correlation structure. The results of the GEE logistic regression model indicate no correlation between successful defibrillation attempts and phase of ventricular activity during VF (p-value = 3D 0.78). From our results, timing of defibrillation shock attempt is not a factor in successful termination of VF for patients undergoing ICD implantation.
NUPARM and NUCGEN: software for analysis and generation of sequence dependent nucleic acid structures

Software packages NUPARM and NUCGEN, are described, which can be used to understand sequence directed structural variations in nucleic acids, by analysis and generation of non-uniform structures. A set of local inter basepair parameters (viz. tilt, roll, twist, shift, slide and rise) have been defined, which use geometry and coordinates of two successive basepairs only and can be used to generate polymeric structures with varying geometries for each of the 16 possible dinucleotide steps. Intra basepair parameters, propeller, buckle, opening and the C6.C8 distance can also be varied, if required, while the sugar phosphate backbone atoms are fixed in some standard conformation in each of the nucleotides. NUPARM can be used to analyse both DNA and RNA structures, with single as well as double stranded helices. The NUCGEN software generates double helical models with the backbone fixed in B-form DNA, but with appropriate modifications in the input data, it can also generate A-form DNA and RNA duplex structures.
Variability in immunophenotype in diffuse large B‐cell lymphoma and its clinical relevance

Diffuse large B‐cell lymphoma (DLBCL), the single largest category of lymphoma, is a clinically and biologically heterogeneous disease entity. Clinically, patients differ in their mode of presentation and respond variably to therapy. A combination of clinical parameters can be used to predict the patient's response to therapy and survival. The pathological variability of DLBCL is expressed in morphology, immunophenotype, cytogenetic and molecular genetic features. Numerous markers detectable by immunohistochemistry and linked to different aspects of tumour biology have been studied in DLBCL, including lineage‐associated and immune markers, proliferation and apoptosis markers, cell adhesion molecules, and more recently stage‐specific markers of B‐cell differentiation. This review summarizes these studies in regard to their clinical significance and in the light of recent advances in our understanding of the molecular pathology and histogenesis of DLBCL.
RecTree Centroid : An Accurate , Scalable Collaborative Recommender

We present a Collaborative Recommender that uses a user-based model to predict user ratings for specified items. The model comprises summary rating information derived from a hierarchical clustering of the users. We compare our algorithm with several others. We show that its accuracy is good and its coverage is maximal. We also show that the algorithm is very efficient: predictions can be made in time that grows independently of the number of ratings and items and only logarithmically in the number of users.
Case studies in reproducibility

Reproducible research is a concept of providing access to data and software along with published scientific findings. By means of some case studies from different disciplines, we will illustrate reasons why readers should be given the possibility to look at the data and software independently from the authors of the original publication. We report results of a survey comprising 100 papers recently published in Bioinformatics. The main finding is that authors of this journal share a culture of making data available. However, the number of papers where source code for simulation studies or analyzes is available is still rather limited.
Stress and Careers

Stress is a major factor in human life, and can influence people in many ways, either positively or negatively. The management of stress is crucial for both individual and organizational processes. Within the work realm, stress can come in the form of occupational stress, job stress, organizational stress and other types of stress-related issues. A number of studies have examined the impact of stress on work attitudes and outcomes, but there is less knowledge and understanding about the specific impact of work-related stress on people’s careers (Clarke & Cooper, 2004, p. 23). In this chapter I will investigate the association in terms of career choice, commitment and success at the individual level, and explore the relevance of organizational interventions like career planning and management for work stress. Much of the literature on stress and its impact focuses on the negative aspects of high-stress environments. There are two principal reasons for this tendency. First, the phenomenon of people suffering from high levels of stress and its negative outcomes (e.g. anxiety, burnout) reflects a reality in many contemporary workplaces. The second reason is concerned with political correctness. It is easier for academic scholars to take the highmoral ground view and preach to managers and executives about the need to be positive, supportive and accommodating towards employees, whereas business needs and fierce competition might mean that many professions and roles are highly demanding. This is particularly true for managerial roles. To compete effectively and motivate employees, managers may need to put a certain level of pressure on their employees. At the same time, effective
Semiconductor loss distribution evaluation for three level ANPC converter using different modulation strategies

Active neutral point clamped (ANPC) converter was developed in order to improve the performances of the neutral point clamped (NPC) converter in terms of the semiconductor loss distribution. Loss distribution depends primarily on modulation type used for generation of the switching signals, therefore it is important to find the appropriate modulation type that will allow the most uniform loss distribution. In order to analyze the behavior of the grid connected ANPC converter a simulation model was created in Plexim blockset Plecs in Matlab/Simulink. Through simulations seven PWM modulations are analyzed for different operating modes and modulation indexes of the ANPC converter in order to find the appropriate modulation method for different operation points of the converter.
Grapheme-to-phoneme conversion using pseudo-morphological units

This paper presents a new approach for grapheme-to-phoneme conversion based on morphology. With this approach, a high accuracy can be obtained, although not for all words a transcription is achieved. The principle of this approach is to automatically decompose an existing pronunciation lexicon into morpheme-similar units called pseudo-morphological units. The pronunciation of the pseudo-morphological units is also generated from the pronunciation lexicon. The pronunciation of unknown words is composed from the pronunciation of its morphemes. With this approach, it is possible to transcribe also abbreviations and words, where a differentiation between spelling and pronunciation-as-a-word is difficult for other approaches. Another advantage of this approach is that it is performed automatically. It can further be used for any language as long as a word based pronunciation lexicon is available.
The partnership for cancer prevention: addressing access to cervical cancer screening among Latinas in South Carolina.

Background Cancer is a leading cause of morbidity and morality among Hispanics, the fastest growing population group in South Carolina (SC). The Partnership for Cancer Prevention (PCP) was established to build partnerships and community capacity to address cervical cancer early detection and control among the growing Latina population in SC. In this paper we report on the initial PCP community-based participatory research (CBPR) project.
Histochemistry as a Unique Approach for Investigating Normal and Osteoarthritic Cartilage

In this review article, we describe benefits and disadvantages of the established histochemical methods for studying articular cartilage tissue under normal, pathological and experimental conditions. We illustrate the current knowledge on cartilage tissue based on histological and immunohistochemical aspects, and in conclusion we provide a short overview on the degeneration of cartilage, such as osteoarthritis. Adult articular cartilage has low capacity to repair itself, and thus even minor injuries may lead to progressive damage and osteoarthritic joint degeneration, resulting in significant pain and disability. Numerous efforts have been made to implement the knowledge in the study of cartilage in the last years, and histochemistry proved to be an especially powerful tool to this aim.
Yeast Kar3 is a minus‐end microtubule motor protein that destabilizes microtubules preferentially at the minus ends.

Mutants of the yeast Kar3 protein are defective in nuclear fusion, or karyogamy, during mating and show slow mitotic growth, indicating a requirement for the protein both during mating and in mitosis. DNA sequence analysis predicts that Kar3 is a microtubule motor protein related to kinesin, but with the motor domain at the C‐terminus of the protein rather than the N‐terminus as in kinesin heavy chain. We have expressed Kar3 as a fusion protein with glutathione S‐transferase (GST) and determined the in vitro motility properties of the bacterially expressed protein. The GST‐Kar3 fusion protein bound to a coverslip translocates microtubules in gliding assays with a velocity of 1‐2 microns/min and moves towards microtubule minus ends, unlike kinesin but like kinesin‐related Drosophila ncd. Taxol‐stabilized microtubules bound to GST‐Kar3 on a coverslip shorten as they glide, resulting in faster lagging end, than leading end, velocities. Comparison of lagging and leading end velocities with velocities of asymmetrical axoneme‐microtubule complexes indicates that microtubules shorten preferentially from the lagging or minus ends. The minus end‐directed translocation and microtubule bundling of GST‐Kar3 is consistent with models in which the Kar3 protein crosslinks internuclear microtubules and mediates nuclear fusion by moving towards microtubule minus ends, pulling the two nuclei together. In mitotic cells, the minus end motility of Kar3 could move chromosomes polewards, either by attaching to kinetochores and moving them polewards along microtubules, or by attaching to kinetochore microtubules and pulling them polewards along other polar microtubules. (ABSTRACT TRUNCATED AT 250 WORDS)
The UA-Prompsit hybrid machine translation system for the 2014 Workshop on Statistical Machine Translation

This paper describes the system jointly developed by members of the Departament de Llenguatges i Sistemes Informatics at Universitat d’Alacant and the Prompsit Language Engineering company for the shared translation task of the 2014 Workshop on Statistical Machine Translation. We present a phrase-based statistical machine translation system whose phrase table is enriched with information obtained from dictionaries and shallowtransfer rules like those used in rule-based machine translation. The novelty of our approach lies in the fact that the transfer rules used were not written by humans, but automatically inferred from a parallel cor-
Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications

Reductions in cerebral metabolism sufficient to impair cognition in normal individuals also occur in Alzheimer's disease (AD). The degree of clinical disability in AD correlates closely to the magnitude of the reduction in brain metabolism. Therefore, we tested whether impairments in tricarboxylic acid (TCA) cycle enzymes of mitochondria correlate with disability. Brains were from patients with autopsy‐confirmed AD and clinical dementia ratings (CDRs) before death. Significant (p < 0.01) decreases occurred in the activities of the pyruvate dehydrogenase complex (−41%), isocitrate dehydrogenase (−27%), and the α‐ketoglutarate dehydrogenase complex (−57%). Activities of succinate dehydrogenase (complex II) (+44%) and malate dehydrogenase (+54%) were increased (p < 0.01). Activities of the other four TCA cycle enzymes were unchanged. All of the changes in TCA cycle activities correlated with the clinical state (p < 0.01), suggesting a coordinated mitochondrial alteration. The highest correlation was with pyruvate dehydrogenase complex (r = 0.77, r2 = 0.59). Measures to improve TCA cycle metabolism might benefit AD patients. Ann Neurol 2005;57:695–703
Neuroprotection and endocytosis: erythropoietin receptors in insect nervous systems

Erythropoietin (Epo) plays a dual role as an erythropoiesis‐stimulating hormone and a locally produced cytoprotectant in various vertebrate tissues. Splice variants and engineered derivatives of Epo that mediate neuroprotection but do not stimulate erythropoiesis suggest that alternative receptors, different from the ‘classical’ homodimeric receptor involved in haematopoiesis, mediate neuroprotective Epo functions. Previous studies on grasshoppers demonstrated neuroprotective and neuroregenerative effects of Epo that involved similar transduction pathways as in mammals. To advance the characterization of yet unidentified neuroprotective Epo receptors, we studied the neuroprotective potency of the human non‐erythropoietic Epo splice variant EV‐3 in primary cultured locust brain neurons. We demonstrate that EV‐3, like Epo, protects locust neurons from hypoxia‐induced apoptotic death through activation of the Janus kinase/signal transducer and activator of transcription transduction pathway. Using the fluorescent dye FM1–43 to quantify endocytotic activity we show that both Epo and EV‐3 increase the number of fluorescently labelled endocytotic vesicles. This reveals that binding of Epo to its neuroprotective receptor induces endocytosis, as it has been described for the mammalian homodimeric Epo‐receptor expressed by erythroid progenitors. Reduction in Epo‐stimulated endocytotic activity following pre‐exposure to EV‐3 indicated that both Epo and its splice variant bind to the same receptor on locust neurons. The shared neuroprotective potency of Epo and EV‐3 in insect and mammalian neurons, in the absence of erythropoietic effects of EV‐3 in mammals, suggests a greater similarity of the unidentified nervous Epo receptors (or receptor complexes) across phyla than between mammalian haematopoietic and neuroprotective receptors. Insects may serve as suitable models to evaluate the specific protective mechanisms mediated by Epo and its variants in non‐erythropoietic mammalian tissues.