Miracle-dz/UniFAR-FTUs huggingface dataset:
Corpus callosotomy in a patient with startle epilepsy

Startle epilepsy is a syndrome of reflex epilepsy in which the seizures are precipitated by a sudden and surprising, usually auditory, stimulus. We describe herein a girl who had been suffering with startle-induced seizures since 2 years of age. She had focal, tonic and tonicclonic seizures, refractory to antiepileptic treatment. Daily tonic seizures led to very frequent falls and morbidity. Neurologically, she had no deficit. Interictal EEG showed slow waves and epileptiform discharges in central and fronto-central regions. Video-polygraphic recordings of seizures, triggered by stimuli, showed generalised symmetric tonic posturing with ictal EEG, characterised by an abrupt and diffuse electrodecremental pattern of fast activity, followed by alpha-theta rhythm superimposed by epileptic discharges predominantly over the vertex and anterior regions. Magnetic resonance imaging showed no abnormalities. Corpus callosotomy was performed when the patient was 17. Since surgery, the patient (one year follow-up) has remained seizure-free. Corpus callosotomy may be considered in patients with startle epilepsy and tonic seizures, in the absence of focal lesions amenable to surgery.
Synchronization of Complex Networks via Aperiodically Intermittent Pinning Control

In this note, synchronization for linearly coupled network is investigated by pinning a simple aperiodically intermittent controller. Nodes' dynamical behaviors in the network are described by continuous-time ordinary differential equations. Some sufficient conditions to guarantee global synchronization are presented. Furthermore, an adaptive algorithm is designed for the pinning control gain and its validity is also proved rigorously. Finally, numerical simulations are given to demonstrate the correctness of obtained results.
Effect of bright light on cycling performance.

PURPOSE The purpose of this study was to examine the effect of exposure to three levels of light intensity during cycling on average power output during an all-out 20-min bout of cycle ergometry. METHODS Twelve male competitive cyclists, with a mean age of 24.3 +/- 3.2 yr, were tested on four separate occasions. During each test session, participants were instructed to produce the highest possible average power output during a 20-min bout of cycle ergometry. Session 1 served as a adaptation trial and was conducted in normal room lighting (approximately 250 lux). In subsequent sessions each participant exercised while sitting in front of a light box. Light intensity was experimentally manipulated through the use of sunglasses that provided high, medium, and low light filtration. Light condition order was counterbalanced. Measurements of heart rate, muscle pain, local perceived exertion, metabolism, and alertness were made during exercise. Mood was assessed before and following exercise with the POMS-BI. RESULTS There were no statistically significant differences in the average total power output in the 1,411 lux (274.9 +/- 21.8 W), 2,788 lux (274.4 +/- 20.5 W), and 6,434 lux (270.3 +/- 19.8 W) light conditions. The difference between the average power output in the brightest and least bright condition (4.6 W) was approximately one-fourth of a pooled SD (d = 0.22). There were no significant differences among the conditions in alertness, leg muscle pain, perceived exertion, heart rate, VO2, or mood responses to the exercise. CONCLUSION It is concluded that exposure to bright light resulting in estimated retinal exposures ranging from 1,411 to 6,434 lux did not have a large or systematic influence on the performance of 20 min of maximal cycle ergometry.
Proportionate gradient updates with PercentDelta

Deep Neural Networks are generally trained using iterative gradient updates. Magnitudes of gradients are affected by many factors, including choice of activation functions and initialization. More importantly, gradient magnitudes can greatly differ across layers, with some layers receiving much smaller gradients than others. causing some layers to train slower than others and therefore slowing down the overall convergence. We analytically explain this disproportionality. Then we propose to explicitly train all layers at the same speed, by scaling the gradient w.r. t. every trainable tensor to be proportional to its current value. In particular, at every batch, we want to update all trainable tensors, such that the relative change of the L1-norm of the tensors is the same, across all layers of the network, throughout training time. Experiments on MNIST show that our method appropriately scales gradients, such that the relative change in trainable tensors is approximately equal across layers. In addition, measuring the test accuracy with training time, shows that our method trains faster than other methods, giving higher test accuracy given same budget of training steps.
IN SUGAR LESSONS FROM THE PAST AND OPPORTUNITIES FOR THE FUTURE By

MANY agricultural industries in Australia consider value chain research a key to improving efficiencies, responsiveness and ultimately market competitiveness. In the Australian sugar industry, value chain research has expanded significantly in the past decade. We have reviewed 16 past and current R&D projects from Australian and overseas sugar industries, which primarily focused on the sectors connecting the farm to the mill. The review has shown that value chain research methodologies have improved considerably in that time, as has industry understanding, acceptance and adoption of the opportunities. Several challenges are also highlighted, including the need to evaluate hard-to-quantify benefits that value chain research produces, accommodate influences from events external to the project and address the high cost of conducting and implementing some value chain research.
Brand Endorsements: An Exploratory Study into the Effectiveness of Using Video Game Characters as Brand Endorsers

Celebrity endorsements have been established as one of the most preferred methods of advertising by marketers (Patel, 2009). Biswas, Hussain and O’Donnell (2009) enumerates five specific benefits of employing celebrity endorsers for a brand, they can be summarised as follows: drawing attention, crisis management, brand repositioning, global marketing, and boosting sales. However the benefits of using a celebrity endorser can be markedly reversed if the celebrity, is involved in a controversial incident, loses credibility by endorsing too many brands, suddenly changes their image, overshadows the brand which is being endorsed, experiences a drop in popularity, is the centre of negative publicity, or fails to perform within their specific career (Erdogan, 1999). As a solution to these problems this research has investigated the use of video game characters as celebrity brand endorsers. Video game characters are celebrities in their own right but they are not plagued by the same risks and problems as ordinary celebrities (Avery, Ferrand, Nicholas & Rowley, 2006; Shimp & Till, 1998). This exploratory study used a quantitative research approach. A self-administered questionnaire using a 7-point Likert scale was developed and piloted. The questionnaire was distributed at the University of the Witwatersrand to a sample group of 484 respondents between the ages of 18 to 25. Fictitious adverts were used as stimuli during the questionnaire. Convenience sampling was used because of time and monetary constraints. The linear regression results proved that video game characters are effective as brand endorsers and can be used in place of an ordinary celebrity to increase the purchase intentions of the target audience. It can be recommended that video game companies seek opportunities to create partnerships with marketers to use their characters as brand endorsers. DOI: 10.5901/mjss.2014. v5n14p260
Theoretical Study on the Detection of Tilted Lipid Bilayers Using Surface Plasmon Resonance Techniques

Effective refractive indices detected using surface plasmon resonance techniques are calculated as a function of the tilt angle of lipid bilayers in a multilayered model. The changes in the effective refractive indices are derived from the shift of an excitation angle of surface plasmon. To obtain effective refractive index plots, we determined refractive index changes in the lipid bilayers with 3 and 5 nm thicknesses as a function of tilt angle and obtained a relationship between the effective refractive index and tilt angle. We also showed that the effective refractive index depended on the lipid bilayers thickness and anisotropic permittivities, which vary with interchain distance.
The effects of stress intensity and stress type on inbreeding depression in Silene vulgaris

Inbreeding depression (ID) is generally assumed to increase under stressful conditions, but a number of studies have found the opposite pattern, that is that crossed offspring were more capable of exploiting benign conditions. Alternatively, the phenotypic variation hypothesis predicts that not stress intensity, but enhanced phenotypic variation in an environment leads to increased ID. We subjected inbred and crossed offspring of Silene vulgaris to drought, simulated herbivory, copper contamination, and two levels of nutrient deficiency and shade. In contrast to the predominant expectation, most stress treatments decreased inbreeding depression. With increasing nutrient limitation, ID decreased strongly, whereas under increasing shade ID did not change. These differences may be due to purging in the population of origin where conditions are nutrient‐poor and dry, but not shaded. In contrast to the greenhouse experiment, ID was higher in a field site than in a more benign common garden. However, the predictions of the phenotypic variation hypothesis were met in both the greenhouse and the field versus garden experiment. The results suggest that there may be no general relationship between ID and stress intensity, but specific effects of stress type and the novelty and variability of the environment.
Insertional activation of a promoterless thymidine kinase gene

A plasmid carrying a promoterless herpes simplex virus thymidine kinase gene was transfected via calcium phosphate precipitation into LM (tk-) mouse fibroblast cells. The transfected gene was efficiently expressed, as the transfected cells grew perfectly well in selective hypoxanthine-aminopterin-thymidine medium, suggesting that the thymidine kinase-coding region became linked to a promoterlike element on integration into the recipient genome. To investigate the structure of the surrogate promoter, we first isolated the integrated gene from a genomic library. The nucleotide sequence of the DNA adjacent to the thymidine kinase-coding sequence was then determined. We found, first, that the integration of the transfected DNA apparently occurred by a blunt end ligation mechanism involving no obvious sequence similarities between integrated and recipient DNA and, second, that the 5'-flanking region included a TATA box, two CCAAT boxes, and a GC box element. However, the TATA box motif and the most proximal CCAAT box appeared to be sufficient for full promoter activity, as determined by the transfection efficiencies of appropriate plasmid constructs. Except for these canonical promoter elements, the surrogate promoter had no obvious similarities to known thymidine kinase gene promoters.
ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

Advances in human genetics are leading to the discovery of new disease-causing mutations at a remarkable rate. Many such mutations, however, occur in genes that encode for proteins of unknown function, which limits our molecular understanding of, and ability to devise treatments for, human disease. Here, we use untargeted metabolomics combined with a genetic mouse model to determine that the poorly characterized serine hydrolase α/β-hydrolase domain-containing (ABHD)12, mutations in which cause the human neurodegenerative disorder PHARC (polyneuropathy, hearing loss, ataxia, retinosis pigmentosa, and cataract), is a principal lysophosphatidylserine (LPS) lipase in the mammalian brain. ABHD12−/− mice display massive increases in a rare set of very long chain LPS lipids that have been previously reported as Toll-like receptor 2 activators. We confirm that recombinant ABHD12 protein exhibits robust LPS lipase activity, which is also substantially reduced in ABHD12−/− brain tissue. Notably, elevations in brain LPS lipids in ABHD12−/− mice occur early in life (2–6 mo) and are followed by age-dependent increases in microglial activation and auditory and motor defects that resemble the behavioral phenotypes of human PHARC patients. Taken together, our data provide a molecular model for PHARC, where disruption of ABHD12 causes deregulated LPS metabolism and the accumulation of proinflammatory lipids that promote microglial and neurobehavioral abnormalities.
Sew-Embed at SemEval-2017 Task 2: Language-Independent Concept Representations from a Semantically Enriched Wikipedia

This paper describes Sew-Embed, our language-independent approach to multilingual and cross-lingual semantic word similarity as part of the SemEval-2017 Task 2. We leverage the Wikipedia-based concept representations developed by Raganato et al. (2016), and propose an embedded augmentation of their explicit high-dimensional vectors, which we obtain by plugging in an arbitrary word (or sense) embedding representation, and computing a weighted average in the continuous vector space. We evaluate Sew-Embed with two different off-the-shelf embedding representations, and report their performances across all monolingual and cross-lingual benchmarks available for the task. Despite its simplicity, especially compared with supervised or overly tuned approaches, Sew-Embed achieves competitive results in the cross-lingual setting (3rd best result in the global ranking of subtask 2, score 0.56).
Revision of Abstract Dialectical Frameworks : Preliminary Report ∗

Abstract Dialectical Frameworks (ADFs) enhance the capability of Dung’s argumentation frameworks by modelling relations between arguments in a flexible way, thus constituting a very general formalism for abstract argumentation. Since argumentation is an inherently dynamic process, understanding how change in ADFs can be formalized is important. In this work we study AGM-style revision operators for ADFs by providing various representation results. We focus on the preferred semantics and employ tools recently developed in work on revision of Horn formulas as well as logic programs. Moreover, we present an alternative family of operators based on a variant of the postulates considering preferred interpretations of the original and admissible interpretations of the revising ADF.Dialectical Frameworks (ADFs) enhance the capability of Dung’s argumentation frameworks by modelling relations between arguments in a flexible way, thus constituting a very general formalism for abstract argumentation. Since argumentation is an inherently dynamic process, understanding how change in ADFs can be formalized is important. In this work we study AGM-style revision operators for ADFs by providing various representation results. We focus on the preferred semantics and employ tools recently developed in work on revision of Horn formulas as well as logic programs. Moreover, we present an alternative family of operators based on a variant of the postulates considering preferred interpretations of the original and admissible interpretations of the revising ADF.
Ventricular arrhythmias and athlete's heart. Role of signal-averaged electrocardiography.

The aim of this study was to assess the prevalence and the prognostic value of ventricular late potentials in apparently healthy top-level athletes with ventricular arrhythmias, and the effect of physiological myocardial hypertrophy (athlete's heart) on the electrogenesis of the signal-averaged electrocardiogram (ECG). Two groups of asymptomatic athletes without underlying heart disease were studied: group A consisted of 35 athletes without arrhythmias and group B of 25 athletes with frequent and complex ventricular arrhythmias (ventricular ectopic beats > 5000.24 h-1 and ventricular couplets > 15.24 h-1). Late potentials were present if athletes had significantly prolonged filtered QRS and low amplitude signal duration and low root mean square voltages at both 25-250 Hz and 40-250 Hz filters. While late potentials were absent in all normal athletes of group A, they were present in seven of 25 (28%) athletes with arrhythmias of group B (P < 0.003). Ten of 25 athletes (five with and five without late potentials) of group B underwent programmed ventricular stimulation using a protocol comprising up to three extrastimuli. No episode of sustained ventricular tachycardia was induced. In four of five athletes with late potentials and in one of five without them, unsustained ventricular responses were induced. Echocardiographically determined left ventricular mass found in both groups of athletes did not influence the pathological result of the signal-averaged ECG parameters. This study shows the applicability of the signal-averaged ECG in identifying ventricular late potentials in a selected population of top-level athletes with frequent and complex ventricular arrhythmias and without overt heart disease; it also shows that the presence of late potentials is not influenced by left ventricular mass, even if extreme ( > 350 g), and it is correlated to a non-sustained ventricular response during an electrophysiological study.
Repeated Game-Inspired Spectrum Sharing for Clustering Cognitive Ad Hoc Networks

The paper studies the cooperative spectrum sharing among multiple secondary users (SUs) in a clustering cognitive ad hoc network. The problem is formulated as a repeated game with the aim of maximizing the total transmission rate of SUs. Firstly, a clustering formation procedure is proposed to reduce the overhead and delay of game process in cognitive radio network (CRN). Then the repeated game-inspired model for SUs is introduced. With the model, the convergence condition of the proposed spectrum-sharing algorithm is conducted, and the convergence performance is investigated by considering the effects of three key factors: transmission power, discount factor, and convergence coefficient. Furthermore, the fairness of spectrum sharing is analyzed, and numerical results show a significant performance improvement of the proposed strategy when compared to other similar spectrum-sharing algorithms.
Alcohol exposure rate control through physiologically based pharmacokinetic modeling.

BACKGROUND The instantaneous rate of change of alcohol exposure (slope) may contribute to changes in measures of brain function following administration of alcohol that are usually attributed to breath alcohol concentration (BrAC) acting alone. To test this proposition, a 2-session experiment was designed in which carefully prescribed, constant-slope trajectories of BrAC intersected at the same exposure level and time since the exposure began. This paper presents the methods and limitations of the experimental design. METHODS Individualized intravenous infusion rate profiles of 6% ethanol (EtOH) that achieved the constant-slope trajectories for an individual were precomputed using a physiologically based pharmacokinetic model. Adjusting the parameters of the model allowed each infusion profile to account for the subject's EtOH distribution and elimination kinetics. Sessions were conducted in randomized order and made no use of feedback of BrAC measurements obtained during the session to modify the precalculated infusion profiles. In one session, an individual's time course of exposure, BrAC(t), was prescribed to rise at a constant rate of 6.0 mg% per minute until it reached 68 mg% and then descend at -1.0 mg% per minute; in the other, to rise at a rate of 3.0 mg% per minute. The 2 exposure trajectories were designed to intersect at a BrAC (t = 20 minutes) = 60 mg% at an experimental time of 20 minutes. RESULTS Intersection points for 54 of 61 subjects were within prescribed deviations (range of ± 3 mg% and ± 4 minutes from the nominal intersection point). CONCLUSIONS Results confirmed the feasibility of applying the novel methods for achieving the intended time courses of the BrAC, with technical problems limiting success to 90% of the individuals tested.
Evidence for a New Mineralocorticoid in Patients with Low‐Renin Essential Hypertension

Patients with low-renin essential hypertension have certain features consistent with excessive mineralocorticoid activity. Because known mineralocorticoids are normal in the majority of low-renin essential hypertension patients, an unknown mineralocorticoid was sought in the urine of such patients. Urine extracts from patients with low-renin essential hypertension were assayed for mineralocorticoid activity in adrenalectomized rats and found to contain more such activity than could be accounted for by the known mineralocorticoids in the extracts. The factor responsible for the unexplained mineralocorticoid activity was purified and then identified by mass spectral analysis as 16/3-hydroxydehy-droepiandrosterone (16β-OH-DHEA). Synthetic 16β-OH-DHEA was found to have a mineralocorticoid potency one-fortieth that of aldosterone in the rat bioassay. The mineralocorticoid effects of both the urine extracts and the synthetic steroid were blocked in the rat by spironolactone, a mineralocorticoid antagonist. A specific assay for 16β-OH-DHEA was developed, and its level in the urine was found to be elevated in patients with low-renin essential hypertension.
Serum N-Terminal Pro–Brain Natriuretic Peptide Is a Sensitive Marker of Myocardial Dysfunction in AL Amyloidosis

Background—Brain natriuretic peptide (BNP) is a marker of ventricular dysfunction and can be used to assess prognosis in heart failure and after myocardial infarction. Heart involvement is the most important prognostic factor and causes death in almost all patients with light-chain amyloidosis (AL). We investigated the prognostic value of NT-proBNP and its utility in monitoring amyloid heart dysfunction. Methods and Results—NT-proBNP was quantified at diagnosis in 152 consecutive patients seen at the coordinating center of the Italian Amyloidosis Study Group (Pavia) from 1999 throughout 2001. Heart involvement was estimated on the basis of clinical signs, electrocardiography, and echocardiography. NT-proBNP concentrations differed in patients with (n=90, 59%) and without (n=62, 41%) heart involvement (median: 507.8 pmol/L versus 22.1 pmol/L, P =10−7). The best cutoff for heart involvement was at 152 pmol/L (sensitivity: 93.33%, specificity: 90.16%, accuracy: 92.05%) and distinguished two groups with different survival (P <0.001). The Cox multivariate model including NT-proBNP was better than models including echocardiographic and clinical signs of heart involvement. NT-proBNP appeared to be more sensitive than conventional echocardiographic parameters in detecting clinical improvement or worsening of amyloid cardiomyopathy during follow-up. Conclusions—NT-proBNP appeared to be the most sensitive index of myocardial dysfunction and the most powerful prognostic determinant in AL amyloidosis. It adds prognostic information for newly diagnosed patients and can be useful in designing therapeutic strategies and monitoring response. NT-proBNP is a sensitive marker of heart toxicity caused by amyloidogenic light chains.