Miracle-dz/UniFAR-FTUs huggingface dataset:
The ventilatory CO2 sensitivities from Read's rebreathing method and the steady‐state method are not equal in man.

1. The ventilatory response to changes in end‐tidal carbon dioxide tension during hyperoxia, obtained with Read's rebreathing method and a steady‐state technique, were compared. 2. In ten young male subjects, forty successful rebreathing and thirteen steady‐state experiments were performed on thirteen different morning sessions. 3. In all subjects the ventilatory CO2 sensitivities obtained with the rebreathing method (Sr) were appreciably larger than the steady‐state CO2 sensitivities (Ss). The ratio Sr/Ss ranged from 1.40 to 2.59 with a mean value of 1.85. 4. We argue that these results can be explained by considering the effect of changes in cerebral blood flow upon increasing the arterial CO2 tension during rebreathing and the steady state. 5. We conclude that in general the CO2 sensitivity obtained with Read's rebreathing method does not represent the steady‐state CO2 sensitivity.
Actions to gain legitimacy in the Swedish financial sector A study of Swedish fintech startups

The financial sector has been undergoing changes the past decade and one reason behind this change is the development of the fintech sector. This new sector has brought new innovations that challenges the incumbents in the financial sector. The new entrants, further referred to as fintech startups, are focusing on developing services in short iterations that reflect the end customers needs. In addition, the fintech startups have a great focus on user experience. The incumbents have dictated the terms in the financial sector for decades and have managed to build regulatory barriers that makes it difficult for new entrants. This dynamic makes it challenging for the fintech startups to navigate in the financial sector in terms of how they should establish their service on a new market. Trust and relationships has historically been building blocks in the financial sector and are aspects that new entrants often lack. In addition, there is a need for legitimacy when operating in the financial sector, some of which is possessed by the incumbents, but also the fintech startups. This thesis aims to describe how Swedish fintech startups establish legitimacy when entering a new market to reduce the liability of newness related to their service. The establishment of legitimacy can be achieved both through internal and external actions for the fintech startups. This research presents different dimensions where actions was taken by Swedish fintech startups to gain legitimacy, these are: innovative, market, historical and compliance. Furthermore, this thesis presents how these dimensions can be gained, both internally for the fintech startup, but also externally through strategic alliances with incumbents. The relationships between the dimensions and different aspects of legitimacy is presented in a model in the end of the thesis.
SYCLOP: synthesis of CMOS logic for low power applications

A system called SYCLOP that synthesizes finite-state machines (FSMs) and combinational logic for low-power applications is presented. SYCLOP tries to minimize the area and the transition density at the internal nodes of a CMOS circuit. The minimization is based on the input signal probabilities and the transition densities. Using this system, a particular circuit can be optimally synthesized for different applications. Results have been obtained for a wide range of benchmark examples. <<ETX>>
Effect of P- Solubilizing Bacteria on Microbial Biomass P and Phosphatase Activity in Groundnut (Arachis hypogaea L) Rhizosphere

Phosphorus is the second most essential macro nutrient after nitrogen required for crop growth (Lal, 2002). Various metabolic processes viz., energy transfer, signal transduction, macro-molecular biosynthesis, photosynthesis, respiration, etc. require P as the key ingredient (Shenoy and Kalagudi, 2005). Mostly soils contain only approximately 1 μmol l -1 soluble P, where as the P requirement by the crops is approximately 30 μmol l -1 soluble P for optimum productivity (Simpson et al., 2011). Plant roots usually absorb P as dihydrogen orthophosphate (H2PO4 ) and monohydrogen orthophosphate (HPO4 -2 ) ion (Panda, 2009). Declined soil reaction (pH) increases the concentration of Fe and Al in soil solution thereby making complexes with aluminum and iron-free oxide sand hydroxides (Fearnside, 1998; Richardson, 2001). Soil acidity thus triggers and increases rate of P fixation as well as immobilization (Fankem et al., 2006). Unlike N, P availability is highly dependent on the type of soil reaction (pH) and no big atmospheric source is there to supplement the P requirement of crops. Again, compared to N and K, total phosphorus level of soils is low and usually one tenth to one fourth of N and one twelfth of K (Jones and Eva, 2011). Thus, P is also International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 4 (2017) pp. 1240-1260 Journal homepage: http://www.ijcmas. com
Thyroid status and diabetes modulate regional differences in potassium currents in rat ventricle.

1. The rate dependence and recovery kinetics of the Ca(2+)‐independent transient (I(t)) and steady‐state or ‘pedestal’ (Iss) outward potassium (K+) currents were studied in single myocytes isolated from epicardial and endocardial regions of rat left ventricles. The whole‐cell, suction microelectrode method was used to measure baseline (fully reactivated) I(t), as well as its rate‐dependent attenuation. Results from a group of control animals were compared with data from three other groups having an experimentally altered hormonal status. 2. I(t) was significantly smaller in endocardial cells than in epicardial cells, in part due to a very large difference in the recovery kinetics of this current in endocardial cells. This was reflected in a pronounced rate‐dependent prolongation of endocardial action potentials. In contrast, the non‐inactivating ‘pedestal’ current, Iss, was very similar in magnitude and showed comparable rate dependence in cells from both epicardium and endocardium. 3. Changing the thyroid status had selective, differential actions on the amplitude and rate dependence of It in epicardial and endocardial cells. Under hypothyroid conditions there was a more pronounced reduction of baseline I(t) in epicardial than in endocardial cells. Moreover, a slowing of the recovery kinetics in epicardial cells resulted in an enhanced attenuation of this current at high rates. Changing thyroid status had no effect on the magnitude or rate dependence of Iss in cells from either region of the left ventricle. 4. Following establishment of hyperthyroid conditions, there was no significant change in I(t) magnitude at baseline. However, when compared with control data, the recovery of I(t) was considerably faster in endocardial cells, and marginally faster in epicardial cells. 5. Streptozotocin‐induced diabetic conditions resulted in a much greater attenuation of I(t) in epicardial cells than in endocardial cells. Epicardial action potentials in these conditions showed prominent rate‐dependent prolongation. Iss was reduced to a similar extent in cells from these two regions. 6. Our findings demonstrate that altered hormonal status can selectively change the amplitude and kinetics of It in the epi‐ and endocardium of rat left ventricle. These changes can reduce the epicardial‐endocardial gradients in the magnitude and recovery kinetics of It and hence diminish the intrinsic differences in both action potential duration and refractoriness.
Sustainable supplier selection in intuitionistic fuzzy environment: a decision-making perspective

Purpose The purpose of this paper is to attempt supplier selection considering economic, environmental and social sustainability issues. Design/methodology/approach Subjective human judgment bears some kind of vagueness and ambiguity; fuzzy set theory has immense potential to overcome this. Owing to the advantage of intuitionistic fuzzy numbers set over classical fuzzy numbers set; three decision-making approaches have been applied here in intuitionistic fuzzy setting (namely, intuitionistic-TOPSIS, intuitionistic-MOORA and intuitionistic-GRA) to facilitate supplier selection in sustainable supply chain. Findings The stated objective of this research “to verify application potential of different decision support systems (in intuitionistic fuzzy setting) in the context of sustainable supplier selection” has been carried out successfully. A case empirical research has been conducted by applying three different decision-making approaches: intuitionistic fuzzy-TOPSIS, intuitionistic fuzzy-MOORA and intuitionistic fuzzy-GRA to an empirical data set of sustainable supplier selection problem. The ranking orders thus obtained through exploration of aforesaid three approaches have been explored and compared. Originality/value As compared to generalized fuzzy numbers, intuitionistic fuzzy numbers exhibit a membership degree, a non-membership degree and the extent of hesitation; a better way to capture inconsistency, incompleteness and imprecision of human judgment. Application potential of aforesaid three decision support approaches has been demonstrated in this reporting for a case sustainable supplier selection.
The influence of perceived price, perceived quality, brand image, and store image on the purchase intention of Hypermart private label

Private label is well known as one of the strategies to expand the market as well as strengthen brand image and store image within stiff competition of retail business. Due to its lower price, the private label could harm perceived quality and affect customer purchase intention. This study aims to examine the relationship among these variables: perceived price, perceived quality, brand image, and store image on the purchase intention of private label. Primary data from 200 respondents was taken with simple random sampling analyzed using linear regression after performed the validity and reliability test. All hypothesis being studied show a positive and significant influence.
Preoxygenation and intraoperative ventilation strategies in obese patients: a comprehensive review

Purpose of review Obesity along with its pathophysiological changes increases risk of intraoperative and perioperative respiratory complications. The aim of this review is to highlight recent updates in preoxygenation techniques and intraoperative ventilation strategies in obese patients to optimize gas exchange and pulmonary mechanics and reduce pulmonary complications. Recent findings There is no gold standard in preoxygenation or intraoperative ventilatory management protocol for obese patients. Preoxygenation in head up or sitting position has been shown to be superior to supine position. Apneic oxygenation and use of continuous positive airway pressure increases safe apnea duration. Recent evidence encourages the intraoperative use of low tidal volume to improve oxygenation and lung compliance without adverse effects. Contrary to nonobese patients, some studies have reported the beneficial effect of recruitment maneuvers and positive end-expiratory pressure in obese patients. No difference has been observed between volume controlled and pressure controlled ventilation. Summary The ideal ventilatory plan for obese patients is indeterminate. A multimodal preoxygenation and intraoperative ventilation plan is helpful in obese patients to reduce perioperative respiratory complications. More studies are needed to identify the role of low tidal volume, positive end-expiratory pressure, and recruitment maneuvers in obese patients undergoing general anesthesia.
The role of organizational communication on employee job satisfaction in telecommunication industry in Kenya

This study seeks to appraise the role of organizational communication on employee job satisfaction in telecommunication industry in Kenya in a bid to improve its effectiveness and applicability in the industry. It aims to achieve this by (1) Examiningthe role of organizational flow of information on employee job satisfaction (2)evaluating the role of communication climate on employee job satisfaction (3)Assessing the role of nature of information on employee job satisfaction and (4)Evaluating the role of information load on employee job satisfaction in telecommunication industry inKenya. In view of the background and literature review, it was found that, organizational communication plays a vital role in ensuring employee job satisfaction. Also, the attributes of organizational flow of information, communication climate, nature of information being shared with employees, and information load, all work together for the benefit of employees’ productivity and satisfaction at work. The study concluded that, the interplay and harmony of these aspects ensure effective organizational communication that leads to job satisfaction. Therefore, there is need to ensure that proper communication strategies are employed in all organizations.
Analysis of cumene (isopropylbenzene) degradation genes from Pseudomonas fluorescens IP01

We obtained the DNA fragments encoding 2-hydroxy-6-oxo-7-methylocta-2,4-dienoic acid (HOMODA) hydrolase in the cumene (isopropylbenzene) degrader Pseudomonas fluorescens strain IP01 via PCR using two synthesized oligonucleotides corresponding to the conserved regions within known meta-cleavage compound hydrolases. Following colony hybridization using the amplified DNA as a probe, a 4.5-kb HindIII fragment was isolated from P. fluorescens IP01. After determining the nucleotide sequence of this fragment, three open reading frames (ORF11 [cumH], ORF12 [cumD], and ORF13) were identified. The deduced amino acid sequence of ORF12 showed homology with meta-cleavage compound hydrolases encoded by the tod, dmp, xyl, and bph operons. Although the product of ORF12 was found to exhibit HOMODA and 2-hydroxy-6-oxohepta-2,4-dienoic acid (HOHDA) hydrolase activities, it did not exhibit 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) hydrolase activity. The deduced amino acid sequence of ORF11 showed 40.4% homology with the sequence of todX in Pseudomonas putida F1 (Y. Wang, M. Ralings, D. T. Gibson, D. Labbé, H. Bergeron, R. Brousseau, and P. C. K. Lau, Mol. Gen. Genet. 246:570-579, 1995). The nucleotide sequence of ORF13 and its flanking region showed strong homology (91.0%) with IS52 from Pseudomonas savastanoi (Y. Yamada, P.-D. Lee, and T. Kosuge, Proc. Natl. Acad. Sci. USA 83:8263-8267, 1982). By characterization of cumH and cumD, the entire cum gene cluster from the cumene-degrader P. fluorescens IP01 (cumA1A2A3A4BCEGFHD) has been identified.
Work Life Balance in the Non-HR Employee Perception the Case of FMCG Companies in Sri Lanka

The study focused on investigating the perception that the non HR employees have regarding the work life balance in their respective organizations in Fast Moving Consumer Goods (FMCG) sector in Sri Lanka. In this study; the data is collected from 16 FMCG companies in Sri Lanka which included 4 foreign (Global) companies and 12 local (Sri Lankan based) companies during the period of 6 months (June 2018 – December 2018). The study adopted the survey strategy with a sample size of 1000. Both the online and manual methods were used in order to collect the data. According to the results obtained it was demonstrated that the perception that the non HR employees have regarding the Work Life Balance in their respective organization to be satisfactory with an average value of 4.5472. However; it was found that there is a gap in between the perception that non HR employees in the local FMCG (Sri Lankan based FMCG companies) companies possess and the perception that non HR employees in the foreign FMCG companies (Global FMCG companies) possess regarding the work life balance in their respective organizations based on the differences in mean values.
Constraints in the diagnosis and treatment of Lassa Fever and the effect on mortality in hospitalized children and women with obstetric conditions in a rural district hospital in Sierra Leone

Results: There were 84 suspected LF cases; 36 (43%) were laboratory-confirmed cases, of whom only 20 (56%) received ribavirin after a median duration of eight days (IQR 314 days) of hospital admission. Of 16 patients who did not receive ribavirin, 14 (87%) died before ribavirin treatment could be commenced. Starting ribavirin within six days of admission was associated with a case fatality of 29% (2/7), while starting ribavirin later than six days was associated with a case fatality of 50% (6/12). Among the 48 suspected LF cases without laboratory confirmation, there were 21 (44%) deaths.
Neurotrophic factor regulation of developing avian oculomotor neurons: differential effects of BDNF and GDNF.

Neurotrophic factors support the development of motoneurons by several possible mechanisms. Neurotrophins may act as target-derived factors or as afferent factors derived from the central nervous system (CNS) or sensory ganglia. We tested whether brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), neurotrophin 4 (NT-4), and glial cell line-derived neurotrophic factor (GDNF) may be target-derived factors for neurons in the oculomotor (MIII) or trochlear (MIV) nucleus in chick embryos. Radio-iodinated BDNF, NT-3, NT-4, and GDNF accumulated in oculomotor neurons via retrograde axonal transport when the trophic factors were applied to the target. Systemic GDNF rescued oculomotor neurons from developmental cell death, while BDNF and NT-3 had no effect. BDNF enhanced neurite outgrowth from explants of MIII and MIV nuclei (identified by retrograde labeling in ovo with the fluorescent tracer DiI), while GDNF, NT-3, and NT-4 had no effect. The oculomotor neurons were immunoreactive for BDNF and the BDNF receptors p75(NTR) and trkB. To determine whether BDNF may be derived from its target or may act as an autocrine or paracrine factor, in situ hybridization and deprivation studies were performed. BDNF mRNA expression was detected in eye muscles, but not in CNS sources of afferent innervation to MIII, or the oculomotor complex itself. Injection of trkB fusion proteins in the eye muscle reduced BDNF immunoreactivity in the innervating motoneurons. These data indicate that BDNF trophic support for the oculomotor neurons was derived from their target.
The Influences of Effectiveness, Competitive Advantages and Market Accessibility on SME Performance in Malaysia

The advent of online business has changed the pattern of doing business recently. This circumstance puts more pressure on SMEs to sustain their position in the fiercely competitive market. Unlike multinational companies, SMEs have several inevitable weaknesses in terms of planning strategy, technology exposure as well as resources that serve as a stumbling block to their better and competitive performance. Thus, online business appears to be a new medium to enhance the performance. Therefore, this study aims to investigate the influences of effectiveness, competitive advantage and market accessibility on SME performance in Malaysia. This study uses cross sectional study which focuses on SMEs that are engaged in online businesses. 200 questionnaires were distributed particularly to SMEs in food and beverages (FB apparel and textile (AT and health and cosmetic (H&C) industries in Malaysia. Results indicate that market accessibility is the only variable which has an influence on entrepreneurs in online businesses within SMEs performance (β=.48, p<.01). This study can shed light on SME performance to the government. For example policy makers can enhance programs and initiatives in the SMEs Master Plan for the year 2012-2020. This study also helps the SMEs avail themselves of the online business opportunity in enhancing their performance. Therefore, the implication of market accessibility in influencing SME performance is discussed in this study.
Governance networks for effective custodians' participation in the sustainability of Langkawi as a geopark

The Global Geopark Networks (GGN) created the concept of "geopark" as a geographically designated area that contains geological, ecological, historical cultural resources for community sustainable development primarily through tourism activities. The Langkawi archipelago has always been rich in such resources and heritage, and was conferred the geopark status by GGN in 2007. Since then, the government and some private, non-governmental organisations have been involved in many geopark projects and activities. Some of them are members of the top down governance system while other parties work independently of one another. For Langkawi to sustain in the long run as a successful and economically developed geopark without the depletion of its geological, ecological, cultural and historical resources, its governance system can be further improved. Effective custodian participation is best achieved through proper governance network system whereby the networks are established between at least two or more organisational and non-organisational custodians irrespective of their social status, ethnicity, gender, wealth and income levels. Specifically, the custodians should work closely together and establish networks in a transparent, accountable, responsible, fair, trustworthy and consistent manner. Effective participation should be in terms of shared norms of behaviour such as cooperation, assistance and influence. Furthermore, such effective participation is based on shared views, shared values, shared norms and other shared aspects guided to some extend by basic network principles such as reciprocity and mutuality. This implies that similarity or commonality is a key feature in social networks formation of the custodians. Trust is also present as a Geraldine K. L. Chan 92 network element. For Langkawi to sustain as a geopark in present and future times, effective participation from all custodians can be achieved through governance networks or social networks. This paper will present some findings from two empirical studies conducted on effective governance networks for the success of Langkawi as a geopark.
Apobec-1 Interacts with a 65-kDa Complementing Protein to Edit Apolipoprotein-B mRNA in Vitro *

The editing of apolipoprotein-B (apoB) mRNA involves the deamination of cytidine at nucleotide 6666 to uridine. The catalytic subunit of the editing enzyme, apobec-1, is a cytidine deaminase that requires other unidentified proteins to edit apoB mRNA in vitro. We partially purified an activity from baboon kidney that functionally complements apobec-1. The complementing activity was protease-sensitive and micrococcal nuclease-resistant, had a native molecular mass of 65 ± 10 kDa on size exclusion chromatography, and sedimented at 4.5 S in glycerol gradients. Purified recombinant His6-tagged apobec-1 immobilized on beads depleted >90% of the complementing activity from partially purified extracts. These beads edited apoB mRNA in vitro in the absence of exogenous apobec-1 or complementing activity. A functional holoenzyme containing apobec-1 and the complementing activity was eluted from the apobec-1-affinity resin using 0.5 M imidazole, whereas buffer containing 0.4 M KCl eluted only the complementing activity. The carboxyl-terminal 59 amino acids of apobec-1 were not required for interaction with the complementing activity in vitro. Our results demonstrate that the complementing protein interacts directly with apobec-1 in the absence of apoB mRNA.