Miracle-dz/UniFAR-FTUs huggingface dataset:
The transketolase gene family of the resurrection plant Craterostigma plantagineum: differential expression during the rehydration phase.

Transketolases, key enzymes of the reductive and oxidative pentose phosphate pathways, are responsible for the synthesis of sugar phosphate intermediates. Here we report the first molecular analysis of transketolase genes from plants. Three distinct classes of transketolase‐encoding cDNA clones were isolated from the desiccation‐tolerant resurrection plant Craterostigma plantagineum. One class represented by the transcript tkt3 is constitutively expressed in leaves and roots under all physiological conditions tested. By biochemical analysis and protein sequencing of purified transketolase, it was shown that tkt3 is expressed in three enzymatically active isoforms. An intriguing discovery was that accumulation of the two other transketolase transcripts, tkt7 and tkt10, is preferentially associated with the rehydration process of the desiccated plant; whereas tkt10 is only expressed in leaves, tkt7 was detected in leaves and roots. This observation suggests a possible role for these transketolases in the conversion of sugars, which are a major phenomenon in the rehydration process. Despite an abundant level of tkt7 and tkt10 transcripts in rehydrating leaves, proteins could not be isolated. This is due in part to a translational control mechanism acting on the loading of mRNAs to polysomes.
Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways

ABSTRACT A rapidly increasing number of RNA helicases are implicated in several distinct cellular processes, however, the modes of regulation of multifunctional RNA helicases and their recruitment to different target complexes have remained unknown. Here, we show that the distribution of the multifunctional DEAH-box RNA helicase Prp43 between its diverse cellular functions can be regulated by the interplay of its G-patch protein cofactors. We identify the orphan G-patch protein Cmg1 (YLR271W) as a novel cofactor of Prp43 and show that it stimulates the RNA binding and ATPase activity of the helicase. Interestingly, Cmg1 localizes to the cytoplasm and to the intermembrane space of mitochondria and its overexpression promotes apoptosis. Furthermore, our data reveal that different G-patch protein cofactors compete for interaction with Prp43. Changes in the expression levels of Prp43-interacting G-patch proteins modulate the cellular localization of Prp43 and G-patch protein overexpression causes accumulation of the helicase in the cytoplasm or nucleoplasm. Overexpression of several G-patch proteins also leads to defects in ribosome biogenesis that are consistent with withdrawal of the helicase from this pathway. Together, these findings suggest that the availability of cofactors and the sequestering of the helicase are means to regulate the activity of multifunctional RNA helicases and their distribution between different cellular processes.
Effective Structured Query Formulation for Session Search

Abstract : In this work, we emphasize on formulating effective structured queries for session search. For a given query, phrase-like text nuggets are identified and formulated into Lemur queries to feed into the Lemur search engine. Nuggets are substrings in qn, similar to phrases but not necessarily as semantically coherent as phrases. We assume that a valid nugget appears frequently in top returned snippets for qn. In this work the longest sequences of words consisting of frequent bigrams within the top returned snippets are identified as nuggets and are used to formulate a new query. By formulating structured query using the nuggets, we greatly boost the search accuracy than just using qn. We experiment both strict and relaxed forms of structured query formulation. The strict form of query formulation achieves an improvement of 13.5% and the relaxed form achieves an improvement of 17.8% on nDCG at 10 on TREC 2011 query sets. We further combine the nuggets generated from all queries q1, . , qn-1, qn, to formulate one structured session query for the entire session. Nuggets from each query are weighed by various weighting schemes to indicate their relations to the current query and their potential contributions to the retrieval performance. We experiment three weighting schemes, uniform (all queries share the same weight), previous vs. current (previous queries q1, ., qn-1 share the same weight while qn uses a different and higher weight), and distance-based (the weights are distributed based on how far a query;s position in the session is from the current query). We find that previous vs. current achieves the best search accuracy. For retrieval, we first retrieve a large pool of documents for qn. We then employ a re-ranking model that considers document similarity between clicked documents and documents in the pool as well as dwell time.
PARDA: Proportional Allocation of Resources for Distributed Storage Access

Rapid adoption of virtualization technologies has led to increased utilization of physical resources, which are multiplexed among numerous workloads with varying demands and importance. Virtualization has also accelerated the deployment of shared storage systems, which offer many advantages in such environments. Effective resource management for shared storage systems is challenging, even in research systems with complete end-to-end control over all system components. Commercially-available storage arrays typically offer only limited, proprietary support for controlling service rates, which is insufficient for isolating workloads sharing the same storage volume or LUN. To address these issues, we introduce PARDA, a novel software system that enforces proportional-share fairness among distributed hosts accessing a storage array, without assuming any support from the array itself. PARDA uses latency measurements to detect overload, and adjusts issue queue lengths to provide fairness, similar to aspects of flow control in FAST TCP. We present the design and implementation of PARDA in the context of VMware ESX Server, a hypervisor-based virtualization system, and show how it can be used to provide differential quality of service for unmodified virtual machines while maintaining high efficiency. We evaluate the effectiveness of our implementation using quantitative experiments, demonstrating that this approach is practical.
German nach-Particle Verbs in Semantic Theory and Corpus Data

In this paper, we present a database-supported corpus study where we combine automatically obtained linguistic information from a statistical dependency parser, namely the occurrence of a dative argument, with predictions from a theory on the argument structure of German particle verbs with """"nach"""". The theory predicts five readings of """"nach"""" which behave differently with respect to dative licensing in their argument structure. From a huge German web corpus, we extracted sentences for a subset of """"nach""""-particle verbs for which no dative is expected by the theory. Making use of a relational database management system, we bring together the corpus sentences and the lemmas manually annotated along the lines of the theory. We validate the theoretical predictions against the syntactic structure of the corpus sentences, which we obtained from a statistical dependency parser. We find that, in principle, the theory is borne out by the data, however, manual error analysis reveals cases for which the theory needs to be extended.
Design of fractional conversion ratio SC DC-DC converters

This paper presents the switched-capacitor (SC) circuit structure whose design conversion ratio is fraction multiple. The proposed converters can step up or step down the input voltage and bidirectional power flow by using dual converters connected. The 2x and 1/2x fraction conversion ratio is specified as a case study. The characteristics of the proposed converters are clarified by theoretical analyses. In addition, the simulation and experimental show the validity of circuit design, where theoretical results correspond well with simulation and experimental results. The proposed converters will be useful for battery charger, battery equalizer and dc power transfer.
International Conference on Research and Innovation in Information Systems – 2013 ( ICRIIS ’ 13 ) Initial framework on identifying factors influencing individuals ’ usage of telehealth

In this study, we proposed a research model to investigate the factors influencing individuals’ usage of telehealth, in particular, MyHealth portal, a subcomponent of telehealth in Malaysia. MyHealth portal’s intention is to provide health and medical information for Malaysians through the internet, and be a source for local information with variety of topics specially related to Malaysians. This information will be useful in future planning of selfprevention, precautions and own care. However, the use of MyHealth portal is still very low despite the benefits it offers. The Uses and Gratifications Theory will be used as a building framework for this study. Data collection processes will involve few interview sessions, which will be used to develop sets of questionnaire to be sent out to individuals who use the MyHealth portal. Keywords-Telehealth, healthcare, MyHealth portal, uses and gratifications;
Label-Free Detection of Human Glycoprotein (CgA) Using an Extended-Gated Organic Transistor-Based Immunosensor

Herein, we report on the fabrication of an extended-gated organic field-effect transistor (OFET)-based immunosensor and its application in the detection of human chromogranin A (hCgA). The fabricated OFET device possesses an extended-gate electrode immobilized with an anti-CgA antibody. The titration results of hCgA showed that the electrical changes in the OFET characteristics corresponded to the glycoprotein recognition ability of the monoclonal antibody (anti-CgA). The observed sensitivity (detection limit: 0.11 µg/mL) and selectivity indicate that the OFET-based immunosensor can be potentially applied to the rapid detection of the glycoprotein concentration without any labeling.
Academic Affiliations of Social Work Journal Article Authors

The academic affiliations of the authors of all regular journal articles published in the Journal of Social Service Research, Social Work, Social Service Review, Journal of Social Work Education, Social Casework, and Child Welfare between 1984-1988 were reviewed and tabulated, producing a ranking of the colleges and universities whose faculty are making the most substantive contributions to the social work literature. The resulls are compared with the findings of a similar, previously published, study covering the years 1979-1983, allowing an assessment of any changes in the relative rankings of these academic institutions.
Beneficial effects of pioglitazone against cardiovascular injury are enhanced by combination with aliskiren in a rat model of diabetic nephropathy

Objectives Aliskiren is the first in a new class of orally active direct renin inhibitors, approved for the treatment of hypertension. However, the efficacy of aliskiren in diabetic cardiovascular complications remains to be defined. This study aimed to test the hypothesis that aliskiren may enhance the beneficial effects of pioglitazone against cardiovascular injury associated with diabetic nephropathy.
Approaches to Class Analysis: Foundations of a neo-Weberian class analysis

Introduction In the broad project of “class analysis” a great deal of effort goes into defining class and delineating the boundaries of classes. This is necessarily so, because class analysis is “the empirical investigation of the consequences and corollaries of the existence of a class structure defined ex-ante ” (Breen and Rottman 1995b, p. 453). By starting from a particular definition, sociologists can assess the extent to which such things as inequality in life chances among individuals and families are structured on the basis of class. This approach stands in contrast to one that discovers a class structure from the empirical distribution of inequality in society (Sorensen 2000 labels this the “nominal classifications” approach). In class analysis the theoretical underpinnings of the version of class that is being used have to be made clear at the outset, and the concept of class has to be operationalized so as to allow claims about class to be tested empirically. If we examine the two main varieties of contemporary class analysis – namely Marxist class analysis, particularly associated with the work of Erik Olin Wright and his associates, and the neo-Weberian class analysis linked to the use of the class schema devised by John Goldthorpe – we find that these two tasks are central to both. In this chapter I will discuss some of the issues involved in seeking to pursue class analysis within a broadly Weberian perspective.
Video Processing on Vehicle Front View Camera

In this project, image processing techniques are used to develop basic understanding on video recording taken by vehicle’s front-view camera. By post processing on the video recording, the computer is able to extract road sign and traffic light information, and make prediction on how fast the vehicle is moving and steering. The road sign recognition is able to identify most of the signs in the video, and traffic light detection achieves decent accuracy on three videos from KITTI benchmark [1]. Forward and steering angular velocity have mean squared error around 0.94 m/s and 0.31 deg/s.
Delirium in Advanced Cancer Leading to Distress in Patients and Family Caregivers

Background: Information is limited about the experiences of delirium among patients with advanced cancer and their caregivers, which makes designing interventions to relieve delirium-related distress difficult. To better understand the experience and thus permit the design of effective interventions, we collected and analyzed data from patients with advanced cancer who had recovered from delirium and their family caregivers. Method: Phenomenolog-ical interviews were conducted separately with 37 caregivers and 34 patients. One investigator reviewed verbatim transcripts of the audio-taped interviews to identify themes, which the research team confirmed. Results: Most patients and all caregivers had vivid memories of the experience; their descriptions were consistent. Most also attributed the confusion to pain medication. Caregivers had concerns about how best to help patients, patients’ imminent deaths, and their own well-being. Conclusions: The main finding that delirium leads to distress for both patients and care-givers indicates the importance of recognizing, treating, and, if possible, preventing delirium in this population. Concerns about pain medications also indicate the need to educate patients and caregivers about symptom management. Caregivers also need emotional support.
Multivariate Analysis: Some Guidelines for Physicians

"Mystified" best characterizes the feeling of many physicians as they read the results of a multivariate analysis. Much of the mystery disappears when two items are shown: (1)explicit tabulationsrevealing how each factor selected by the analysis relates to outcome, both singly and jointly with other factors; and (2)alternative modelsgenerated by repeating the analysis after removing the most important variables one by one from the list of factors that was initially analyzed. In this way, one can determine which variables are good stand-ins or substitutes for the best variables in the initial analysis. Showing these substitutes may expose exaggerations in benefits attributed to a particular therapy (ie, elective regional node dissection for clinical stage I malignant melanoma). We have applied these guidelines to examples in the literature, particularly studies of malignant melanoma. (JAMA1983;249:641-643)
Triple-site biventricular pacing in patients undergoing cardiac resynchronization therapy: a feasibility study.

AIMS To evaluate implantation safety and efficiency of triple-site (double left-single right) cardiac resynchronization therapy (CRT) and to assess the outcome of this procedure. METHODS AND RESULTS Twenty-six patients with New York Heart Association (NYHA) class III-IV, left ventricular ejection fraction (EF) < or = 35%, and QRS > or = 120 ms underwent triple-site CRT. Procedural course and complications were analysed. NYHA class, QRS duration, echocardiographic parameters, peak oxygen consumption (VO(2)max), and 6 min walking distance (6MWD) were assessed at baseline and after 3 months. Responders were defined by survival, by no re-hospitalization for heart failure, and by >10% EF, VO(2)max, and 6MWD increase. Implantation was successful in 22 patients (84.6%). Procedure duration (199.1 min) and fluoroscopy time (38.7 min) were higher than in standard procedures. Two clinically silent coronary sinus dissections occurred intra-operatively; one phrenic nerve stimulation and one pocket infection were observed during follow-up. After 3 months of CRT, a significant reduction (P < 0.05) of NYHA class, increment of VO(2)max, 6MWD, EF, and improvement of indices of dyssynchrony were observed. Response rate in the studied group was 95.4%. CONCLUSION Triple-site resynchronization appears to be a safe and efficient treatment method, with high response rate. Further studies are needed to evaluate the role of this pacing mode in CRT.
Implementation of Cooperative Learning in the Center for Community Service and Continuing Education at Kuwait University.

The purpose of this study is to review the success of implementation of cooperative learning in various courses delivered at the Center for Community Service and Continuing Education at Kuwait University. According to recent research in the fi eld of social cognition, learning situations which make use of the social context often achieve superior results over individualistic experiences. Interviews with 200 university teachers conducted for the last two years showed their experience and opinions about the effects of cooperative learning in their classrooms on the achievement of content knowledge, retention and students’ attitudes toward it. The results of this study revealed that about 75% of the teachers believed that cooperative learning had been successfully implemented. The present analysis offers a series of positive fi ndings and recommendations to improve further the educational standard of the Centre in Kuwait University. Introduction
Answer validation by keyword association

Answer validation is a component of question answering system, which selects reliable answer from answer candidates extracted by certain methods. In this paper, we propose an approach of answer validation based on the strengths of lexical association between the keywords extracted from a question sentence and each answer candidate. The proposed answer validation process is decomposed into two steps: the first is to extract appropriate keywords from a question sentence using word features and the strength of lexical association, while the second is to estimate the strength of the association between the keywords and an answer candidate based on the hits of search engines. In the result of experimental evaluation, we show that a good proportion (79%) of a multiple-choice quiz "Who wants to be a millionaire" can be solved by the proposed method.
Neural Machine Translation Leveraging Phrase-based Models in a Hybrid Search

In this paper, we introduce a hybrid search for attention-based neural machine translation (NMT). A target phrase learned with statistical MT models extends a hypothesis in the NMT beam search when the attention of the NMT model focuses on the source words translated by this phrase. Phrases added in this way are scored with the NMT model, but also with SMT features including phrase-level translation probabilities and a target language model. Experimental results on German-to-English news domain and English-to-Russian e-commerce domain translation tasks show that using phrase-based models in NMT search improves MT quality by up to 2.3% BLEU absolute as compared to a strong NMT baseline.
Systemic hemodynamics during sleep in young or middle-aged and elderly patients with essential hypertension.

Age-related changes in cardiovascular regulatory mechanisms may affect blood pressure homeostasis during sleep and in the daytime. This study compared systemic hemodynamics during the daytime and sleep between 12 young or middle-aged patients (young, 42.1 +/- 13.9 years old, mean +/- SD, less than 56 years old) and 12 elderly patients with essential hypertension (old, 65.3 +/- 2.8, 60 to 70 years old). They were all hospitalized and placed on a diet containing approximately 7 g sodium chloride per day. Intra-arterial blood pressure and electrocardiogram were recorded for 24 hours, and electroencephalogram and electroophthalmogram were recorded during the night with a telemetric method. Cardiac output was measured with patients in the supine position by the cuvette method during the daytime and stage 3 or 4 sleep at night. The averaged 24-hour blood pressure was similar in the two groups (140 +/- 2 [SEM]/85 +/- 3 mm Hg in the young group and 144 +/- 4/81 +/- 2 mm Hg in the old group). The reduction in mean blood pressure during sleep was also comparable in both groups (-18 +/- 2 in the young group and -20 +/- 2 mm Hg in the old group). Cardiac index was smaller in the old group than the young group during both the daytime and sleep (daytime, 2.3 +/- 0.1 versus 3.2 +/- 0.2 [L/min]/m2, P < .01; sleep, 2.1 +/- 0.1 versus 2.6 +/- 0.2 [L/min]/m2, P < .01). The reduction in cardiac index during sleep was greater in the young than the old group (P < .05). (ABSTRACT TRUNCATED AT 250 WORDS)
Engaging Learners with Complex Learning Difficulties and Disabilities: A resource book for teachers and teaching assistants

1 The Engagement for Learning Framework: an introduction 2 New generation children: the complex learning challenge 3 Engagement and learning: a brief introduction 4 Evidencing engagement for learning: the Engagement Profile and Scale 5 Personalizing engagement: case studies 6 Learning with families 7 Together everyone can achieve more: collaborating with other professionals 8 Mental health and children with complex learning difficulties and disabilities: a ticking time bomb 9 Inquiry gives you wings: school-based inquiry and engaging children with complex learning difficulties and disabilities 10 Visioning the future: schools taking forward the Engagement for Learning Framework APPENDIX A Instructions on completing the Engagement Ladders APPENDIX B Complex Learning Difficulties and Disabilities Briefing Packs APPENDIX C The Inquiry Framework for Learning APPENDIX D Complex Learning Difficulties and Disabilities Project questionnaires APPENDIX E Accessible Research Cycle template APPENDIX F Project information and consent form relating to the Complex Learning Difficulties and Disabilities Project APPENDIX G Engagement passport example from Parkside School, Pukekohe, New Zealand APPENDIX H Parkside School's 'Engagement Profile and Scale Final Report' template APPENDIX I Schools involved in the original Complex Learning Difficulties and Disabilities Research Project (2009-2011)
Unifying SAT-based and Graph-based Planning

The Blackbox planning system unifies the planning as satisfiability framework (Kautz and Selman 1992, 1996) with the plan graph approach to STRIPS planning (Blum and Furst 1995). We show that STRIPS problems can be directly translated into SAT and efficiently solved using new randomized systematic solvers. For certain computationally challenging benchmark problems this unified approach outperforms both SATPLAN and Graphplan alone. We also demonstrate that polynomialtime SAT simplification algorithms applied to the encoded problem instances are a powerful complement to the "mutex" propagation algorithm that works directly on the plan graph.