Miracle-dz/UniFAR-FTUs huggingface dataset:
Reliability and stability of a semistructured DSM-IV interview designed for family studies.

OBJECTIVE To determine the interrater reliability and stability of diagnoses, and to compare the results of in-person versus telephone administration of the Missouri Assessment of Genetics Interview for Children (the MAGIC), a new, semistructured, glossary-based diagnostic interview for children and adolescents. METHOD The interview was developed for a large-scale epidemiological family genetics study. For reliability measures, parent report on offspring, child self-report, and adolescent self-report interviews were independently scored by two different raters on a population-based sample of respondents. The stability of diagnoses was assessed by comparing repeat interviews of parents, children, and adolescents, separated on average by 13 months. Frequencies of parent and adolescent report of disorders were determined for telephone and in-person interviews. RESULTS High interrater reliabilities were achieved for individual DSM-IV symptoms and diagnoses and for individual characteristics of diagnostic domains, including number, clustering, duration, and impairment of symptoms. The stability of diagnoses was also high for parents and adolescents. No significant differences in the prevalence of attention-deficit/hyperactivity disorder and major depressive disorder were found for interviews administered in person or by telephone. CONCLUSIONS The MAGIC demonstrates high interrater reliability and stability for DSM-IV symptoms and diagnoses.
Computer-aided design, analysis and optimization of HMIC SOP broadband balanced amplifier

The purpose of this paper is to present a complete design and analysis of new HMIC 3.5-4.5 GHz broadband balanced amplifier modules using microstrip technology. Two different modules are designed and analyzed. Each module is implemented in a single substrate. The first module used Lange couplers as power splitters and combiners while the second used branch couplers. The components of the modules are designed using full-scale computer simulation program, performed by the author and named as MSDES, which takes fully into account all the discontinuities included in the microstrip lines; while the modules are analyzed and optimized using APLAC V7.61 software. A short and efficient CAD procedure for the broadband amplifier design is introduced. The first step is to design an initial narrowband high-gain microstrip amplifier at a center frequency equal to 4 GHz. The second step is to optimize the initial lengths and widths of the input and output microstrip-matching circuits to get the broadband amplifier over the range 3.5-4.5 GHz. The analyses of both narrow and broadband amplifiers are introduced in addition to the complete analysis of the designed 3.5-4.5 broadband balanced amplifier modules. The analysis of the designed balanced amplifier modules shows better efficiency and good performance. The complete AC schematic diagrams of the designed balanced amplifier modules are presented. These modules can be used in many applications including sensors, pulse Doppler communications, airborne radars, traffic control radars and satellite communications.
Ion exchange phase transitions in water-filled channels with charged walls.

Ion transport through narrow water-filled channels is impeded by a high electrostatic barrier. The latter originates from the large ratio of the dielectric constants of the water and the surrounding media. We show that "doping," i.e., immobile charges attached to the walls of the channel, substantially reduces the barrier. This explains why most of the biological ion channels are "doped. " We show that at rather generic conditions the channels may undergo ion exchange phase transitions (typically of the first order). Upon such a transition a finite latent concentration of ions may either enter or leave the channel, or be exchanged between the ions of different valences. We discuss possible implications of these transitions for the Ca-vs-Na selectivity of biological Ca channels. We also show that transport of divalent Ca ions is assisted by their fractionalization into two separate excitations.
Effect of Effective Microorganisms (EM) and Potassium Sulphate on Productivity and Fruit Quality of "Hayany" Date Palm Grown Under Salinity Stress

An experiment trial was carried out in a private orchard at Ras-Sudr, South Sinai Governorate, Egypt, during the two successive seasons of 2012 and 2013 to study the effect of effective microorganisms biofertilizer (EM) at 60 and 90 ml/palm/year and potassium sulphate at 1 and 1.5 kg/palm/year as well as their combinations in alleviating the adverse effect of salinity on productivity of "Hayany" date palm. From the obtained results showed that it is preferable to add EM at 90ml / palm/ year combined with potassium sulphate at 1.5kg/palm/year as a soil application divided into three equal doses applied at three times a year to enhance leaf chlorophyll content, fruit set percentage, retained fruit percentage, yield, fruit quality and leaf minerals content of "Hayany" date palm.
Characterization of the first Clostridium baratii strain responsible for an outbreak of botulism type F in France

Christelle Mazuet1, Jean Sautereau1, Christine Legeay1, Christiane Bouchier2, Philippe Bouvet1, Nathalie Jourdan da Silva3, Christine Castor4 and Michel R Popoff1* 1Institut pasteur, Bactéries anaérobies et Toxines, Paris, France, 2Institut pasteur, Plateforme Génomique, Paris, France, 3French institute of public health, Department of infectious disease, SaintMaurice, France, 4French institute of public health, Department of coordination of alerts and regions, Regional office in Aquitaine, Bordeaux, France Abstract
Komplexitätsmessung von Produktmodellen

Das Ziel dieser Arbeit ist die individuelle, quantifizierte Bewertung der Komplexitat als Kennzahl der Produktivitat im Entwicklungscontrolling auf Grundlage der Produktmodelle. Dies umfasst zum Beispiel 3D-CAD-Modelle, Funktionsmodelle, Quellcode oder Anforderungsdokumente. Kernelement ist ein Konzept zur individuellen Analyse der Abhangigkeit des Aufwands von Attributen und Relation der Modellelemente und von Strukturen in einem Produktmodell. Hierzu wird das Produktmodell als Graph reprasentiert und durch eine Vielzahl generisch erzeugter Knotenmetriken beschrieben. Diese Beschreibung wird durch eine Regressionsanalyse ausgewertet und resultiert in einem Schatzmodell fur die Komplexitat im Sinne des Aufwands zur Erzeugung. Durch dieses Modell kann eine Kennzahl „Komplexitat“ gemessen und Produktmodelle quantitativ miteinander verglichen werden.
Improving quality and productivity at an automotive component manufacturing organisation in Durban - South Africa

The manufacturing sector is considered to be an important industry in any country and is often plagued with a significant degree of competition. In order to cope with this competition, organisations attempt to improve their manufacturing operations by using different tools and techniques to reduce costs and improve profits. This study investigated the existing lean manufacturing tool of an automotive organisation in Durban. The objective of this study was to identify the strengths and weaknesses of the current lean manufacturing process in improving quality and productivity. An empirical study was conducted, using a survey questionnaire with an assessment score ranking to gather and evaluate employees’ responses pertaining to this lean application in their production environment. The quantitative method of research was adopted. The results of the study showed evidence of misalignment and inconsistencies for lean manufacturing in the organisation. Several important findings on the implications of lean activities that affect manufacturing performance were revealed. The study concluded that a significant gap exists between the actual adoption of lean manufacturing on the shop floor to those that are documented.
A New Demodulation and Modulation Method Designed for FMCW Radar

An efficient demodulation method designed for FMCW (Frequency-Modulated Continuous Wave) radar is presented. It is a kind of modified DFT (IDFT) algorithm; the spectrum segment of interest can be easily extracted from the original signal without calculating the whole DFT/FFT. It provides fast demodulation and extraction of desired frequency bands in our HFSWR (High-Frequency Surface Wave Radar) system. The proposed approach enhances the performances of radar system and reduces the computing complexity. The new structure could also be inversely used for signal modulation. And also arbitrary sampling rate conversion could be achieved with the combination of forward and backward structure.
Reference interval computation using robust vs parametric and nonparametric analyses.

The clinical chemist is faced with the problem of defining reference intervals for many analytes. Problems that hinder such a determination are the presence of outliers in the data set and the inability to accumulate the recommended sample size (1). We previously have demonstrated the theoretical basis for the application of robust methods to resolve these problems (2). In particular, we consider the problem of establishing that the reference population is “healthy” to be a nearly impossible task because many disease processes may be missed in the examination process. Our own experience shows that diabetics were initially classified as healthy in our test population, and only after a thorough review of all of the data was it possible to elicit the presence of this disease. In this report, we propose the use of a robust estimator we have described previously (2). The advantage of this approach is that it is more tolerant of outliers in the reference population data and does not require as large a sample size as the nonparametric calculation method, nor does it require the reference data to be transformed to a gaussian distribution, which is not always possible. We then apply and compare this robust estimator with both the traditional nonparametric and parametric analysis in determining reference intervals for a well-studied population. The Fernald Medical Monitoring Program provided us with a documented healthy sample (T) to test the three methods: parametric, nonparametric, and robust. Our computer-generated sample (W) offered the possibility to test our estimates of reference intervals in a population with a greater potential incidence of diseases (3). The robust approach offered the opportunity to look at …
The Past, Present, and Future of Multidimensional Scaling

Multidimensional scaling (MDS) has established itself as a standard tool for statisticians and applied researchers. Its success is due to its simple and easily interpretable representation of potentially complex structural data. These data are typically embedded into a 2-dimensional map, where the objects of interest (items, attributes, stimuli, respondents, etc.) correspond to points such that those that are near to each other are empirically similar, and those that are far apart are different. In this paper, we pay tribute to several important developers of MDS and give a subjective overview of milestones in MDS developments. We also discuss the present situation of MDS and give a brief outlook on its future.
Dichlorido(methanol-κO)[2-(2-pyridylmethoxy)-1,10-phenanthroline-κ3 N,N′,N′′]manganese(II)

In the title mononuclear complex, [MnCl2(C18H13N3O)(CH4O)], the MnII ion assumes a distorted octahedral geometry. There is a π–π stacking interaction between the phenanthroline ligand and the pyridine ring of a neighboring complex [centroid-to-centroid distance 3.5518 (13) Å]. The crystal structure also contains weak intermolecular O—H⋯Cl hydrogen bonds that link neighboring complex molecules into a one-dimensional chain along the b axis.
T Follicular Helper Cell Dynamics in Germinal Centers

Help Shared Germinal centers are specialized structures within lymph nodes, where B cells undergo the changes required to produce high-affinity antibodies. This process relies on T follicular helper (Tfh) cells. The dynamic properties of Tfh cells and how they affect the selection of B cells, however, are not well understood. Using two-photon laser scanning microscopy of mouse lymph nodes, Shulman et al. (p. 673, published online 25 July) find that Tfh cells are not restricted to a single germinal center, but instead emigrate into neighboring germinal centers within the same lymph nodes. Furthermore, newly activated T cells can enter already established germinal centers and presumably influence ongoing B cell selection and differentiation. Such active movement may ensure maximal diversification of the B cell response and promote the production of high-affinity antibodies. Tracking individual cells reveals that immunological T cell help is shared between immune B cell germinal centers. T follicular helper (TFH) cells are a specialized subset of effector T cells that provide help to and thereby select high-affinity B cells in germinal centers (GCs). To examine the dynamic behavior of TFH cells in GCs in mice, we used two-photon microscopy in combination with a photoactivatable fluorescent reporter. Unlike GC B cells, which are clonally restricted, TFH cells distributed among all GCs in lymph nodes and continually emigrated into the follicle and neighboring GCs. Moreover, newly activated TFH cells invaded preexisting GCs, where they contributed to B cell selection and plasmablast differentiation. Our data suggest that the dynamic exchange of TFH cells between GCs ensures maximal diversification of T cell help and that their ability to enter ongoing GCs accommodates antigenic variation during the immune response.
Making better Maxent models of species distributions: complexity, overfitting and evaluation

Models of species niches and distributions have become invaluable to biogeographers over the past decade, yet several outstanding methodological issues remain. Here we address three critical ones: selecting appropriate evaluation data, detecting overfitting, and tuning program settings to approximate optimal model complexity. We integrate solutions to these issues for Maxent models, using the Caribbean spiny pocket mouse, Heteromys anomalus, as an example.
PPGIS in Community Development Planning: Framing the Organizational Context

This article examines the local variability of public participation GIS (PPGIS) by urban community revitalization organizations, arguing that this variability is in part shaped by a variety of organizational factors. Existing research has shown PPGIS production to be highly context dependent, identifying an ever-growing set of key elements of this context, including a variety of locally available resources for GIS access and use as well as organizational capacities and characteristics. Contributing to current efforts to expand the conceptual basis of PPGIS research, this article argues that the conceptualization of organizational context must be expanded beyond internal capacities to include organizational networks with local actors, institutions, and resources; organizational knowledge and stability; and organization mission and priorities, all of which shape its activities and relationships, as well as the utility of available GIS resources. This broadened conception of organizational context enables a .
Regional quadratic problem for distributed bilinear systems with bounded controls

In this paper, we establish the approximate controllability of a class of distributed bilinear systems evolving in a spatial domain Ω. A bounded feedback control is used to drive a dynamical system from an initial state to a desired one in finite time, only on a subregion ω of the system domain. Our purpose is to prove that an regional optimal control exists, and characterized as a solution to an optimality system. Numerical approach is given and successfully illustrated by simulations. AMS Subject Classification: 93B05, 93B52, 49K35
Antenna selection technique for MIMO-OFDM systems over frequency selective Rayleigh fading channel

A joint transmit and receive antenna selection technique for MIMO-OFDM is presented. By appropriately ordering and tabulating the minimum channel sub-matrix's sub-stream signal to noise ratio in all subcarriers, an optimal antenna subset can be obtained. This procedure can be simplified further by analysing the inter-subcarrier correlation and by exploiting group selection methods. Complexity analyses on the proposed algorithm are presented, and performance improvements achievable are demonstrated through simulation studies.
Anonymization scheme using non-trusted agent for location based services

The possibility for the leakage of a user's location information and the content of the service request query in the use of the location based services raised the issue of personal information protection. To solve this problem, in the traditional approaches, an anonymity region was defined and used such that it is hard to identify the user from the knowledge on the content of a specific query and the associated location information. Meanwhile, the system proposed here does not require to form an anonymity region and protects the personal information using non-trusted agent. That is, it does not allow for inferring the user identity from the location information and the query content.
Prognostic significance of monocytosis in patients with myeloproliferative disorders

Based on clinical and pathological findings, chronic myelomonocytic leukemia (CMML) differs from other myeloproliferative/myelodysplastic disorders by its hallmark, monocytosis. It is unknown whether the presence of monocytosis and the diagnosis of CMML carry a prognostic significance. The present study aimed to determine whether the survival of patients with CMML differs from that of patients with BCR/ABL-negative CML or Ph1−, BCR/ABL-unknown CML, once other potentially prognostic variables have been accounted for. The records of 485 patients with myeloproliferative/myelodysplastic disorders [CMML, n = 304; BCR/ABL-negative CML, n = 107; Ph1−, BCR/ABL unknown, n = 74] were analysed. Of the covariates found to be significantly (P < 0.01) associated with survival in univariate and multivariate analyses, the following remained predictive and adversely associated with survival, after accounting for the influence of other covariates: increasing age, white blood cell count, platelets, bone marrow blasts and cellularity, decreasing hemoglobin, abnormal karyotype, and diagnosis of CMML. The diagnosis of CMML is prognostically significant and independently associated with a shorter survival and a higher risk of death than BCR/ABL-negative CML or Ph1− BCR/ABL-unknown CML.
Disaster Management and GIS

Disaster management programs begin with locating and identifying potential emergency problems. Using a GIS, officials can pinpoint hazards and can evaluate the consequences of potential emergencies. GIS facilitates this process by allowing planners to view the appropriate combinations of spatial data through computer-generated maps. As potential emergency situations are identified, mitigation needs can be determined and prioritized. Disaster management team can begin to formulate mitigation, preparedness, response, and recovery program needs. Availability of real time information, tailored software's, distributed computing and real time analysis has facilitated the job of decision makers; and accordingly reduce the havoc which otherwise would have ensued. Updating of data through high resolution satellite imageries and use of disaster management software is discussed in detail whereas ground shaking has been considered as typical disaster scenario
Neurological Imaging in Acquired Cranial Nerve Palsy: Ophthalmologists vs. Neurologists

ABSTRACT Purpose: Cranial nerve palsies often require neurological imaging by MRI. Guidelines on whether or not to utilize MRI have been absent or lack clarity. In daily practice, both neurologists and ophthalmologists treat patients with cranial nerve palsy and determine whether neuro-imaging is required. There appear to be differences in policy with respect to neuro-imaging. The question, which will be answered in this study, is the following: to what extent do differences in policy exist between ophthalmologists and neurologists regarding imaging by MRI of patients with acquired ocular cranial nerve palsy? Method: PubMed database was searched for literature on acquired cranial nerve palsy and MRI scanning performed by ophthalmologists and neurologists. Case series published between 2000 and 2015 were included. The first author screened the literature on eligibility, profession of the authors, and conducted data abstraction. Result: Ten case series were found eligible for analysis. A total of 889 cranial nerve palsies were described, 770 by ophthalmologists and 119 by neurologists. The age range of patients in all case series was 2 to 96 years of age. The oculomotor nerve was investigated in 162 patients, the trochlear nerve in 131 patients, and the abducens nerve in 486 patients. All neurologists (n=3) and 2 out of 7 investigated ophthalmologists recommended performing MRI scanning in every patient who presented with an ocular cranial nerve palsy, while 5 ophthalmologists (5/7) opted to triage patients for risk factors associated with cranial nerve palsies prior to ordering MRI imaging. When different groups of patients were viewed separately, it became apparent that almost all specialists agreed that every patient with a third nerve palsy and patients under 50 years of age should undergo MRI scanning. In patients with fourth nerve palsy, MRI scanning was not indicated. Conclusion: The neurologists in this study were more likely to perform MRI scanning in every patient presenting with ocular cranial nerve palsy. Ophthalmologists were more likely to determine risk factors associated with cranial nerve palsy, which they took into account when deciding whether or not to perform neurological imaging in patients aged more than 50 years or presenting with abducens nerve palsy.
Neuropeptide Y and Luteinizing Hormone Releasing Hormone Synergize to Stimulate the Development of Cellular Follicle‐Stimulating Hormone in the Hamster Adenohypophysis

Luteinizing hormone releasing hormone (LHRH) stimulates the development of cellular FSH immunoreactivity in the perinatal hamster adenohypophysis. Because neuropeptide Y (NPY) can act directly on rat adenohypophysial cells to stimulate FSH and LH release and potentiate the stimulatory effect of LHRH on FSH and LH release, we investigated the effects of NPY alone and in combination with a low, ineffective dose of LHRH on inducing cellular FSH immunoreactivity in the neonatal hamster adenohypophysis. Neonatal female pituitary glands were grafted beneath the right renal capsules of hypophysectomized‐ovariectomized adult hamster hosts with a catheter implanted in the external jugular vein. After treatment, hosts were decapitated and graft tissue was stained for FSH and LH immunoreactivity. The mean percentage of adenohypophysial cells that stained for FSH was low (2.8%) in grafts in hosts infused continuously with heparinized saline vehicle for 7 days. In other hosts, peptides were pulsed through the catheter every 12 h for 7 days. The mean percentage of FSH cells also was low after pulsing 6 ng LHRH or 2 μg NPY but increased substantially when the two peptides were pulsed simultaneously. No differences in the mean percentage of LH cells existed between any of the groups. The results demonstrate that NPY and LHRH can synergize to induce cellular FSH immunoreactivity in the neonatal female hamster.