Miracle-dz/UniFAR-FTUs huggingface dataset:
Using Levins verb classification for preposition sense selection in English to Indian language MT

The paper describes an initial attempt to use Levin’s verb classes for the task of preposition sense selection in English to Indian language machine translation. Two language pairs have been selected to describe the approach, English-Hindi and English-Telugu. We exploit the correspondence of verb class’s semantics vis-à-vis some prepositions it takes. Results obtained from the experiments show very high performance with an overall average accuracy of 93.6% for English-Telugu language pair. When combined with previous approach, the performance increased by 6.2%.
Permanent post-concussion symptoms after mild head injury

Objective: A small minority of individuals experience long-term or permanent post-concussion symptoms (PCS) after a mild head injury (MHI). There has been no systematic, quantitative research examining a wide range of variables in a representative sample of such patients (i.e. with PCS for more than 18 months). This study explores a broad spectrum of demographic, cognitive, emotional and psychosocial factors (known to be important in the development of early PCS) in a representative sample of patients with permanent PCS. Method: One hundred consecutively referred patients to a Community Head Injury Service in Buckinghamshire, UK for the treatment of persistent PCS, at least 18 months post-MHI, were identified and invited to participate. An exploratory design evaluated a range of demographic, cognitive, emotional and psychosocial variables and their relationship to PCS severity and quality-of-life (QoL). Results: Twenty-four participants, with a mean time post-injury of 6.9 years, responded. They were characterized by: (i) older age compared to those typically presenting with MHI, (ii) very high levels of PCS, (iii) high post-injury unemployment, (iv) pre- or post-morbid factors which might exacerbate post-concussional difficulties, (v) elevated levels of anxiety and depression and (vi) mildly reduced scores on tests of short-term memory and speed of information processing. Post-hoc analysis of the total sample (n = 100) confirmed older age and a high proportion having pre- or post-morbid factors. QoL negatively correlated with PCS severity, and anxiety scores accounted for 45.9% of the variance in PCS severity. Conclusions: Very high levels of PCS, high post-injury unemployment and measurable cognitive deficits can be permanent features of MHI. Quality-of-life is directly related to symptom severity. Age, pre-/post-morbid concomitant factors, neuropsychological deficits and emotional status are key variables in understanding the phenomenon of permanent PCS. Important vulnerability factors in the development of such may therefore be older age and any additional compromise to an individual's emotional or cognitive capacities.
Analysis of functional MRI time‐series

A method for detecting significant and regionally specific correlations between sensory input and the brain's physiological response, as measured with functional magnetic resonance imaging (MRI), is presented in this paper. The method involves testing for correlations between sensory input and the hemodynamic response after convolving the sensory input with an estimate of the hemodynamic response function. This estimate is obtained without reference to any assumed input. To lend the approach statistical validity, it is brought into the framework of statistical parametric mapping by using a measure of cross‐correlations between sensory input and hemodynamic response that is valid in the presence of intrinsic autocorrelations. These autocorrelations are necessarily present, due to the hemodynamic response function or temporal point spread function. © 1994 Wiley‐Liss, Inc.
Edinburgh Research Explorer Development of a chicken 5 K microarray targeted towards immune function

Background: The development of microarray resources for the chicken is an important step in being able to profile gene expression changes occurring in birds in response to different challenges and stimuli. The creation of an immune-related array is highly valuable in determining the host immune response in relation to infection with a wide variety of bacterial and viral diseases. Results: Here we report the development of chicken immune-related cDNA libraries and the subsequent construction of a microarray containing 5190 elements (in duplicate). Clones on the array originate from tissues known to contain high levels of cells related to the immune system, namely Bursa, Peyers patch, thymus and spleen. Represented on the array are genes that are known to cluster with existing chicken ESTs as well as genes that are unique to our libraries. Some of
Comparative analysis of diagnostic performance, feasibility and cost of different test-methods for thyroid nodules with indeterminate cytology

Since it is impossible to recognize malignancy at fine needle aspiration (FNA) cytology in indeterminate thyroid nodules, surgery is recommended for all of them. However, cancer rate at final histology is <30%. Many different test-methods have been proposed to increase diagnostic accuracy in such lesions, including Galectin-3-ICC (GAL-3-ICC), BRAF mutation analysis (BRAF), Gene Expression Classifier (GEC) alone and GEC+BRAF, mutation/fusion (M/F) panel, alone, M/F panel+miRNA GEC, and M/F panel by next generation sequencing (NGS), FDG-PET/CT, MIBI-Scan and TSHR mRNA blood assay. We performed systematic reviews and meta-analyses to compare their features, feasibility, diagnostic performance and cost. GEC, GEC+BRAF, M/F panel+miRNA GEC and M/F panel by NGS were the best in ruling-out malignancy (sensitivity = 90%, 89%, 89% and 90% respectively). BRAF and M/F panel alone and by NGS were the best in ruling-in malignancy (specificity = 100%, 93% and 93%). The M/F by NGS showed the highest accuracy (92%) and BRAF the highest diagnostic odds ratio (DOR) (247). GAL-3-ICC performed well as rule-out (sensitivity = 83%) and rule-in test (specificity = 85%), with good accuracy (84%) and high DOR (27) and is one of the cheapest (113 USD) and easiest one to be performed in different clinical settings. In conclusion, the more accurate molecular-based test-methods are still expensive and restricted to few, highly specialized and centralized laboratories. GAL-3-ICC, although limited by some false negatives, represents the most suitable screening test-method to be applied on a large-scale basis in the diagnostic algorithm of indeterminate thyroid lesions.
A robust iterative method for Born inversion

We present a robust iterative method to solve the inverse scattering problem in cases where the Born approximation is valid. We formulate this linearized inverse problem in terms of the unknown material contrast and the unknown contrast sources and we solve the problem by minimizing a cost functional consisting of two terms. The first term represents the differences between the actual data and the modeled data, while the second term represents the misfit in the constitutive relations between the contrast sources and the incident fields. In each iteration, the contrast sources and the contrast are reconstructed alternatingly, using subsequently a conjugate gradient step for the contrast source updates and a direct inversion of a diagonal matrix for the contrast. A further regularization with a multiplicative regularization factor is discussed. In this regularization procedure the relative variation of the contrast is minimized as well. As a test case we consider the two-dimensional (2-D) transverse magnetic polarization problem. Synthetic numerical examples are presented in order to compare the presented algorithm to the traditional Born algorithm. Results with respect to the inversion of experimental data are presented as well. In addition, some inversion results for the subsurface sensing problem, both in two and three dimensions, are presented.
Acute Administration of Unacylated Ghrelin Has No Effect on Basal or Stimulated Insulin Secretion in Healthy Humans

Unacylated ghrelin (UAG) is the predominant ghrelin isoform in the circulation. Despite its inability to activate the classical ghrelin receptor, preclinical studies suggest that UAG may promote β-cell function. We hypothesized that UAG would oppose the effects of acylated ghrelin (AG) on insulin secretion and glucose tolerance. AG (1 µg/kg/h), UAG (4 µg/kg/h), combined AG+UAG, or saline were infused to 17 healthy subjects (9 men and 8 women) on four occasions in randomized order. Ghrelin was infused for 30 min to achieve steady-state levels and continued through a 3-h intravenous glucose tolerance test. The acute insulin response to glucose (AIRg), insulin sensitivity index (SI), disposition index (DI), and intravenous glucose tolerance (kg) were compared for each subject during the four infusions. AG infusion raised fasting glucose levels but had no effect on fasting plasma insulin. Compared with the saline control, AG and AG+UAG both decreased AIRg, but UAG alone had no effect. SI did not differ among the treatments. AG, but not UAG, reduced DI and kg and increased plasma growth hormone. UAG did not alter growth hormone, cortisol, glucagon, or free fatty acid levels. UAG selectively decreased glucose and fructose consumption compared with the other treatments. In contrast to previous reports, acute administration of UAG does not have independent effects on glucose tolerance or β-cell function and neither augments nor antagonizes the effects of AG.
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Étude de validation d'une echelle multidimensionnelle de perfectionnisme

Le perfectionnisme est maintenant considere comme un domaine multidimensionnel. Frost et al. (1990) ont ete les premiers a developper un questionnaire destine a evaluer les dimensions du perfectionnisme dans des groupes cliniques et issus de la population generale. L'objectif de notre etude est de presenter la validation de la version francophone du questionnaire de Frost et al. (1990) : l'Echelle des Standards Personnels. Trois groupes ont ete compares : des patients obsessionnels compulsifs (n = 50), des sujets phobiques sociaux (n =37) et des sujets issus de la population generale (n = 183). Les trois groupes ont ete compares pour l'âge, le sexe et le niveau d'etudes. Les resultats confirment la validite et la consistance interne. La stabilite temporelle de l'instrument a ete etablie. Comme predits, les patients obsessionnels compulsifs (TOC) et les sujets phobiques sociaux presentent un niveau total de perfectionnisme statistiquement plus eleve que celui du groupe controle. Les patients ayant un TOC ont un score plus eleve que les sujets phobiques sociaux a la dimension Doute concernant les actions. Cette dimension semble specifique au trouble obsessionnel compulsif. La stabilite factorielle de l'instrument originel n'a pas ete confirmee. Nous retrouvons une solution a quatre facteurs. Notre analyse suggere de fusionner d'une part les sous-echelles Preoccupations face aux erreurs et Doute, et d'autre part les sous-echelles Attentes et Critiques parentales.
Active Preference Learning with Discrete Choice Data

We propose an active learning algorithm that learns a continuous valuation model from discrete preferences. The algorithm automatically decides what items are best presented to an individual in order to find the item that they value highly in as few trials as possible, and exploits quirks of human psychology to minimize time and cognitive burden. To do this, our algorithm maximizes the expected improvement at each query without accurately modelling the entire valuation surface, which would be needlessly expensive. The problem is particularly difficult because the space of choices is infinite. We demonstrate the effectiveness of the new algorithm compared to related active learning methods. We also embed the algorithm within a decision making tool for assisting digital artists in rendering materials. The tool finds the best parameters while minimizing the number of queries.
Collective Intelligence for Optimal Power Flow Solution Using Ant Colony Optimization

This paper presents the performance ant collective intelligence efficiency for electrical network. Solutions for Optimal Power Flow (OPF) problem of a power system deliberate via an ant colony optimization metaheuristic method. The objective is to minimize the total fuel cost of thermal generating units and also conserve an acceptable system performance in terms of limits on generator real and reactive power outputs, bus voltages, shunt capacitors/reactors, transformers tap-setting and power flow of transmission lines. Simulation results on the IEEE 30-bus electrical network show that the ant colony optimization method converges quickly to the global optimum.
Expression of aquaporin-1 in human trabecular meshwork cells: role in resting cell volume.

PURPOSE Drainage of aqueous humor from the human eye appears dependent on intracellular volume of trabecular meshwork (TM) cells, the predominant cell type of the human outflow pathway. Thus, the modulation of water and solute flux across the plasma membrane of TM cells is predicted to be an important factor in regulating outflow facility. Aquaporin (AQP)-1 is a hexahelical integral membrane protein that functions as a regulated channel for water and cations in fluid-secreting and -absorbing tissues. AQP1 is present in many tissues of the human eye, including the TM; however, its role in outflow facility is unknown. The purpose of the present study was twofold: to evaluate the prospect of manipulating AQP1 protein levels in TM cells using sense and antisense mRNA and to investigate the functional role of AQP1 in TM cells. METHODS An adenovirus (AV) expression system was used to alter AQP1 protein levels. AQP1 protein expression was monitored using immunoblot analysis, and resting cell volume was measured by forward light scatter, electronic cell sizing, and [(14)C]-sucrose/urea equilibration. Permeability of TM monolayers to [(14)C]-sucrose was also assessed as an indirect evaluation of cell volume. RESULTS AV-mediated gene transfer of AQP1 cDNA to TM cells resulted in a titer-dependent increase in recombinant AQP1, whereas transfer of antisense cDNA decreased native AQP1 protein by 71.7% +/- 5.5% (P < 0.01) after 5 days. A novel finding of this study is that mean resting volumes of AQP1(s) AV-infected TM cells in suspension were 8.7% +/- 3.0% greater (P < 0.05) than control cells. Conversely, AQP1 antisense (as) AV-infected cells had resting volumes 7.8% +/- 2.9% less than control cells (P < 0.05). Similar effects of AQP1 expression on resting cell volume were observed in TM monolayers. Consistent with this finding, paracellular permeability of AQP1(s) AV-infected TM monolayers to [(14)C]-sucrose decreased by 8.0% +/- 1.4% (P < 0.001). CONCLUSIONS In addition to influencing the osmotic permeability of TM plasma membranes, the level of AQP1 protein expression influences resting intracellular volume and thus paracellular permeability of TM cell monolayers in vitro. These data suggest that AQP1 expression may affect outflow facility in vivo.
A context approach to measuring similarity between questions in the community-based QA services

There is an increasing number of community-based question and answer (cQA) service on the Web. Many tasks in cQA services involve in determining similarity between questions. However, finding similar questions is not trivial. In this paper we propose a new method based on a query expansion technique to tackle the similar question matching problem. We employ the information provided by the corresponding answer and question & answer pairs from cQA services to determine the similarity between questions. We empirically show that with this method it is possible to find semantically similar questions even though they may not share any actual terms in common.
Demand in My Pocket: Mobile Devices and the Data Connectivity Marshalled in Support of Everyday Practice

This paper empirically explores the role that mobile devices have come to play in everyday practice, and how this links to demand for network connectivity and online services. After a preliminary device-logging period, thirteen participants were interviewed about how they use their iPhones or iPads. Our findings build a picture of how, through use of such devices, a variety of daily practices have come to depend upon a working data connection, which sometimes surges, but is at least always a trickle. This aims to inform the sustainable design of applications, services and infrastructures for smartphones and tablets. By focusing our analysis in this way, we highlight a little-explored challenge for sustainable HCI and discuss ideas for (re)designing around the principle of 'light-weight' data 'needs'.
A posteriori Rake finger selection in space-time coded CDMA systems

We present the optimal Rake finger selection criterion that minimizes the a posteriori probability of symbol error in space-time block coded code division multiple access (CDMA) systems. It can serve as a benchmark for the performance of all a posteriori Rake finger selection criteria. Then we present suboptimal, but more practical, finger selection criteria based on a posteriori symbol error probability bounds, and analyze the bit error probability as a function of constellation sizes and number of resolvable paths. Simulation results show that there is a significant gain over the traditional signal strength-based selection criterion
The Identification of Prolonged Length of Stay for Surgery Patients

When the hospitalization periods of an unexpectedly high number of patients are extended, the income of a hospital is substantially affected and the rate of hospital bed occupancy increases. Because none of the currently available score systems can be used to evaluate the possibility that patients who require urgent surgery in a single department prolong their length of stay (LOS), this study attempts to build a prolonged LOS prediction model utilizing a number of supervised learning techniques. This study involved analyzing the complete historical medical records and lab data of 897 clinical cases in which surgeries were performed by general surgery physicians. These clinical cases were divided into an urgent operation (UO) group comprising 462 cases and a non-UO group comprising 434 cases to develop a prolonged LOS prediction model by using several supervised learning techniques. The results indicated that the random forest method constituted the most accurate and stable prediction model. This study demonstrated that supervised learning techniques can be used to analyze patient medical records to accurately predict a prolonged LOS, thus, supervised learning techniques can serve as valuable reference tools for patient prognoses. The developed prediction models can facilitate the decision making of physicians when patients require surgery and increase patient safety.
Resilience to reoffending : mechanisms supporting young men to overcome adversity

This study investigated the mechanisms supporting young men’s resilience to reoffending. Resilience was defined as “the outcome from negotiations between individuals and their environments for the resources to define themselves as healthy amidst conditions collectively viewed as adverse” (Ungar, 2004a, p.32). The philosophical approach was critical realist (Bhaskar, 1978) and the methodology used was narrative enquiry, employing content analysis (Lieblich et al., 1998) to elicit mechanisms from the data. Eight young men with previous involvement in the criminal justice system were recruited from organisations in Hastings, East Sussex. They participated in a narrative interview which explored their life stories and the mechanisms utilised to change their offending trajectory. The study used Hart and Blincow’s Resilient Therapy (RT) Framework (2007), to categorise the data. Mechanisms within the framework, located within categories such as Basics, Belonging, Learning, Core Self and Coping, were applied to the young men’s experience, to understand the application of RT in promoting resilience to reoffending. All categories of RT were pertinent in nurturing their pathways to resilience. Further analysis of the data elicited additional resilient mechanisms absent within RT. Proposed additions included Clothes within the Basics compartment, and Humour, an important mechanism facilitating coping and affiliation, included within the Belonging and Coping compartments. Social capital was instrumental to the young men’s resilience, providing them with essential coping resources; a further recommendation was to rename the Belonging compartment “social capital”. This research challenges common discourses of risk. The young men demonstrated how the experiences and environments where they encountered risk were important in cultivating their resilience to reoffending. Within counselling psychology, this reinforces the notion of focusing on the subjective experience of the individual, embracing uncertainty, bracketing assumptions and extending traditional boundaries when promoting resilience with vulnerable young men. This study corroborated existing research demonstrating resilience as the outcome of both individual and social processes (Luthar and Cicchetti, 2000; Prilleltensky, 2005; Hart and Blincow, 2007). With respect to counselling psychology practice it presents a challenge to individualised therapeutic interventions, encouraging counselling psychologists to become active participants in changing the social systems that impact on an individual’s resilience, reconciling their roles as healers with their role as change agents. RT (Hart and Blincow, 2007) provides a systemic application of mechanisms targeting both micro- and macro-level processes, offering an extension to counselling psychology practice necessary to promote resilience to reoffending.
Multiplex PCR assay for malaria vector Anopheles minimus and four related species in the Myzomyia Series from Southeast Asia

Abstract. Mosquitoes (Diptera: Culicidae) of the Anopheles (Cellia) Myzomyia Series are important malaria vectors in Africa, India and Southeast Asia. Among 10 named species of Myzomyia known from the Oriental Region, seven form the An. minimus group. Even for expert taxonomists, the adults of these species remain difficult to identify morphologically. For technical staff of malaria control programmes, confusion may extend to misidentification of species that are not formally within the minimus group. For identification of specimens from Indochina (Cambodia, Laos, Vietnam), we describe a multiplex polymerase chain reaction (PCR) assay, based on rDNA internal transcribed spacer 2 (ITS2) sequences, that employs a cocktail of primers to identify An. minimus Theobald sibling species A and C (sensu; Green et al., 1990) and three other species in the An. minimus group (An. aconitus Dönitz, An. pampanai Büttiker & Beales, An. varuna Iyengar), as well as An. jeyporiensis James, also belonging to the Myzomyia Series. As the test is DNA‐based, it can be applied to all life stages of these mosquitoes for ecological investigations and vector incrimination studies. This PCR assay is simpler, quicker, cheaper and more readily interpreted than previous assays.