Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of cytochromes P450 involved in the human liver microsomal metabolism of the thromboxane A2 inhibitor seratrodast (ABT-001).

Seratrodast (ABT-001, AA-2414) undergoes cytochrome P450 (CYP)-dependent metabolism to a major (5-methylhydroxy seratrodast; 5-HOS) and a minor 4'-hydroxy seratrodast metabolite in human liver microsomes. The mean apparent K(m) and Vmax for the formation of 5-HOS were 15.5 microM and 589.0 pmol 5-HOS formed/mg protein/min, respectively. Chemical inhibition using isoform-selective CYP inhibitors, correlation of 5-HOS formation with several isoform-specific CYP activities in a panel of liver microsomes, metabolism by microsomes derived from CYP cDNA-expressed B-lymphoblastoid cells, and immunoinhibition by isoform-specific anti-CYP antibodies indicated that 5-HOS formation is catalyzed by CYP3A and CYP2C9/10, with a minor contribution from CYP2C8 and CYP2C19. At clinically relevant concentrations, seratrodast was found to inhibit tolbutamide methylhydroxylation (IC50 = 60 microM), (S)-mephenytoin 4'-hydroxylation (IC50 = 50 microM), and coumarin 7-hydroxylation (IC60 = 95 microM), indicating the potential for significant clinical interactions. The inducers of CYP3A and/or CYP2C9 (e.g. rifampicin and phenytoin) are likely to alter the disposition of seratrodast.
DBkWik: Towards Knowledge Graph Creation from Thousands of Wikis

Popular public knowledge graphs like DBpedia or YAGO are created from Wikipedia as a source, and thus limited to the information contained therein. At the same time, Wikifarms like Fandom contain Wikis for specific topics, which are often complementary to the information contained in Wikipedia. In this paper, we show how the DBpedia approach can be transferred to Fandom to create DBkWik, a complementary knowledge graph.
Implementation of a real-time multi-channel gateway server in ubiquitous integrated biotelemetry system for emergency care (UIBSEC)

We developed a gateway server to support various types of bio-signal monitoring devices for ubiquitous emergency healthcare in a reliable, effective, and scalable way. The server provides multiple channels supporting real-time N-to-N client connections. We applied our system to four types of health monitoring devices including a 12-channel electrocardiograph (ECG), oxygen saturation (Sp02), and medical imaging devices (a ultrasonograph and a digital skin microscope). Different types of telecommunication networks were tested: WIBRO, CDMA, wireless LAN, and wired internet. We measured the performance of our system in terms of the transmission rate and the number of simultaneous connections. The results show that the proposed network communication strategy can be successfully applied to the ubiquitous emergency healthcare service by providing a fast rate enough for real-time video transmission and multiple connections among patients and medical personnel.
Time Series Data Analysis for Forecasting - A Literature Review

In today's world there is ample opportunity to clout the numerous sources of time series data available for decision making. This time ordered data can be used to improve decision making if the data is converted to information and then into knowledge which is called knowledge discovery. Data Mining (DM) methods are being increasingly used in prediction with time series data, in addition to traditional statistical approaches. This paper presents a literature review of the use of DM and statistical approaches with time series data, focusing on weather prediction. This is an area that has been attracting a great deal of attention from researchers in the field.
Data denoising and interpolation using synthesis and analysis sparse regularization

Missing trace reconstruction is a challenge in seismic processing due to incomplete and irregular acquisition. Noise is a concern, due to the many sources of noise that occur during seismic acquisition. Most of the recent research on denoising and interpolation focuses on transform domain approaches using L1 norm minimization. A specific kind of constraint, called the synthesis approach, is widely used in geophysical problems. The analysis approach, which can be considered as the synthesis’ dual problem, is an alternative for sparsityconstrained inversion. Although less popular than the synthesis solution, the analysis approach is more effective in several problems, such as denoising of natural images. We compare and contrast the analysis and synthesis approaches as sparsity constraints for the missing trace reconstruction and denoising problems. We show that the analysis approach yields more accurate results than the synthesis approach, which makes it a viable approach for sparsity-constrained inversion for noise related geophysical problems.
Gait related risk factors for exercise-related lower leg pain during shod running

PURPOSE Exercise-related lower-leg pain (ERLLP) is a common chronic sports injury. In clinical practice, deviant gait biomechanics are frequently considered to play a role in the development of ERLLP, although there is scarce scientific evidence that gait-related variables predispose athletes to this injury. The purpose of this study was to examine prospectively the gait-related risk factors for ERLLP during shod running in a young, physically active population. METHODS The gait pattern during shod running of 400 physical education students was evaluated at the beginning of their academic study. This was accomplished by means of plantar pressure measurements and 3D gait kinematics. After this evaluation, the same sports physician registered all sports injuries during this study. RESULTS During the follow-up period, 46 subjects developed ERLLP, of whom 29 subjects had bilateral complaints. Thus, 75 symptomatic lower legs (35 left and 40 right) were classified into the ERLLP group. Bilateral feet of 167 subjects who sustained no injuries at the lower extremities served as the referent group. Cox regression analysis revealed that subjects who will develop ERLLP have an altered running pattern compared with the referent subjects. More specifically, these subjects showed a significantly increased pronation excursion, accompanied by more pressure underneath the medial side of the foot, a delayed maximal eversion, and an accelerated reinversion. CONCLUSION The findings of this study suggest that altered gait biomechanics during shod running play a role in the genesis of ERLLP and, thus, should be considered in prevention and rehabilitation of this pathology.
Investigation of Radiation E-ciency and Bandwidth of Electrically Small MNG ZOR Metamaterial Antenna

In this paper, the radiation e-ciency and fractional bandwidth of an electrically small zeroth order resonance (ZOR) antenna based on mu-negative (MNG) metamaterials were theoretically investigated. To investigate the radiation e-ciency and bandwidth of the electrically small antenna, various types of MNG ZOR antennas such as a meander line inductor and a spiral inductor with difierent current path have been designed. The equivalent circuits of MNG ZOR antennas are derived for theoretical analysis of an antenna. The parameters of antenna such as radiation resistance and dissipated loss have been obtained by the equivalent circuit of the MNG ZOR antennas. The dissipated loss and radiation resistance were afiected by the current distribution of meander line and the direction of current path of the antenna. It is conflrmed that both the radiation e-ciency and bandwidth of the MNG ZOR antenna can be improved when the cancellation of current on the antenna is minimized if the losses are assumed to be the same.
A new wide area measurement system model based on common information model

WAMS (Wide Area Measurement System) is a newly developed technology, which can provide a reliable guarantee to the simultaneous measurement of power system. But PMU (Phasor Measurement Unit) can not be widely used in power grid now, so it is impossible that WAMS can replace SCADA (Supervisory Control And Data Acquisition) system presently. Hence, how to incorporate WAMS measuring data into other systems including SCADA has become a hot research topic currently especially the data exchange between them. In order to solve this problem, a CIM (Common Information Model)-based information model for WAMS is proposed in this paper according both to IEC 61970: EMS-API (Energy Management System Application Program Interface) part 303 and the principle and the application of WAMS. This paper establishes a new package named WAMS in the framework of CIM and then some extended classes and their attributes along with their relationships are also defined. Finally this paper briefly describes the application of this CIM-based information model by presenting a flow diagram about information integration and utilization between WAMS and SCADA.
Multiple root finder algorithm for Legendre and Chebyshev polynomials via Newton ’ s method

We exhibit a numerical technique based on Newton’s method for finding all the roots of Legendre and Chebyshev polynomials, which execute less iterations than the standard Newton’s method and whose results can be compared with those for Chebyshev polynomials roots, for which exists a well known analytical formula. Our algorithm guarantees at least nine decimal correct ciphers in the worst case, however, when comparing with Chebyshev roots given by its formula, even eighteen decimal correct ciphers are achieved in several roots, in the best case. As a comparison guide the results are collated with those gotten by MATLAB.
Experiments with a Camera-Based Human-Computer Interface System

A human-computer interface (HCI) system called " The Camera Mouse " is evaluated. It tracks a user's movements with a video camera and translates them to movements of the mouse pointer on the screen [1]. The main objectives for the experimentation were to quantitatively define the performance of the system for different users, features, and applications, to determine the optimal settings for different kinds of users, and to compare measurements over all users in order to suggest enhancements to a future system of this type. The experiments were conducted with 11 participants including a subject with severe physical disabilities. Each subject repeatedly performed a number of tasks. During each trial, a different feature was tracked and the elapsed time and mouse movement trajectories were measured. These measurements were used to quantify the system's performance.
Security for decentralized health information systems.

Health care information systems must reflect at least two basic characteristics of the health care community: the increasing mobility of patients and the personal liability of everyone giving medical treatment. Open distributed information systems bear the potential to reflect these requirements. But the market for open information systems and operating systems hardly provides secure products today. This 'missing link' is approached by the prototype SECURE Talk that provides secure transmission and archiving of files on top of an existing operating system. Its services may be utilized by existing medical applications. SECURE Talk demonstrates secure communication utilizing only standard hardware. Its message is that cryptography (and in particular asymmetric cryptography) is practical for many medical applications even if implemented in software. All mechanisms are software implemented in order to be executable on standard-hardware. One can investigate more or less decentralized forms of public key management and the performance of many different cryptographic mechanisms. That of, e.g. hybrid encryption and decryption (RSA+DES-PCBC) is about 300 kbit/s. That of signing and verifying is approximately the same using RSA with a DES hash function. The internal speed, without disk accesses etc., is about 1.1 Mbit/s. (Apple Quadra 950 (MC 68040, 33 MHz, RAM: 20 MB, 80 ns. Length of RSA modulus is 512 bit).
OS + Hardware Application Translation Engine Code Cache Application Code Request for Translation Translated Code Region Executable Code

The need for adaptability in a rapidly expanding embedded systems market makes it important to design virtual execution environments (VEEs) specifically targeting embedded platforms. We believe the first step in this direction should be to replace the performance focus of traditional VEE design with a combined memory and performance focus, given the memory constraints on embedded systems. In this work, we present techniques that reduce the large code cache sizes of VEEs by continually eliminating dead cached code as the guest application executes. We use both a time-based heuristic and an execution count-based heuristic to predict code lifetime. When we determine that the lifetime of code has ended, we remove it from the code cache. We found that at least 20% code cache reduction can be achieved on average, without a significant performance degradation.
Membrane-less photoelectrochemical cells: product separation by hydrodynamic control

A key step in order to realise photo-electrochemical (PEC) water splitting to produce hydrogen sustainably, is reactor design. Good engineering will minimise energy losses (both optical and ohmic) due to reactor construction, whilst ensuring the H2 and O2 produced are separated, and this can subsequently relax the requirements on the photo-absorber material and/or electro-catalysts. In this paper we show that separation of the products through hydrodynamic flow alone would negate the need for the conventionally used membrane, which has an associated ohmic drop and cost. This is demonstrated to be possible using a ‘laminar flow between two parallel plates’ reactor design and AR/Pe and AR are found to be the two key dimensionless numbers that predict product cross-over (where AR, Pe are aspect ratio and Peclet number respectively). Supersaturation was used as an indicator of bubble formation, which disrupts the laminar flow required for separation and it is shown that by increasing the reactor pressure, higher current densities can be tolerated before supersaturation occurs. Removal of the dissolved hydrogen and oxygen from electrolyte is discussed. A multi-physics model, which employs an optical transfer matrix method, is used to validate the previous conclusions. Experimental data for hematite and Pt deposited on FTO was used as the anode and cathode respectively. Parasitic optical losses and efficiency improvement with stacking are shown for the example reactor configuration. Additionally, the concept of stacking this reactor design in order to absorb light in multiple passes is introduced. This approach relaxes a classical constraint on photo-absorber materials: large absorption length compared to small diffusion length of charge carriers in the semiconductor.
Intracellular Distribution and Nuclear Activity of Antisense Oligonucleotides After Unassisted Uptake in Myoblasts and Differentiated Myotubes In Vitro

Clinical efficacy of antisense oligonucleotides (AONs) for the treatment of neuromuscular disorders depends on efficient cellular uptake and proper intracellular routing to the target. Selection of AONs with highest in vitro efficiencies is usually based on chemical or physical methods for forced cellular delivery. Since these methods largely bypass existing natural mechanisms for membrane passage and intracellular trafficking, spontaneous uptake and distribution of AONs in cells are still poorly understood. Here, we report on the unassisted uptake of naked AONs, so-called gymnosis, in muscle cells in culture. We found that gymnosis works similarly well for proliferating myoblasts as for terminally differentiated myotubes. Cell biological analyses combined with microscopy imaging showed that a phosphorothioate backbone promotes efficient gymnosis, that uptake is clathrin mediated and mainly results in endosomal-lysosomal accumulation. Nuclear localization occurred at a low level, but the gymnotically delivered AONs effectively modulated the expression of their nuclear RNA targets. Chloroquine treatment after gymnotic delivery helped increase nuclear AON levels. In sum, we demonstrate that gymnosis is feasible in proliferating and non-proliferating muscle cells and we confirm the relevance of AON chemistry for uptake and intracellular trafficking with this method, which provides a useful means for bio-activity screening of AONs in vitro.
Modelling drying and loading effect in structural concrete repair

Drying shrinkage may be a significant cause of deterioration of thin concrete repairs. Shrinkage induced stresses can be partially relieved by tensiie creep. Hydration effects and materials properties may have a significant influence on concrete repair behaviour. In this paper, a numerical tool that takes into account these different phenomena is presented. The aim of this numerical modei is to obtain an analysis tool to complete experimental tests. Experimental results obtained on small lab specimens permit to calibrate numerical coefficients. Numerical results on larger specimens show a good agreement with experimental data.
Beyond MSER: Maximally Stable Regions using Tree of Shapes

This article explores the application of a tree-based feature extraction algorithm for the widely-used MSER features, and proposes a Tree of Shapes based detector of Maximally Stable Regions. Changing an underlying component tree in the algorithm allows considering alternative properties and pixel orderings for extracting the Maximally Stable Regions. Differences introduced to the region structure with changing the underlying tree are discussed, as well as the spatial organization of the detected regions imposed by using a self-dual image representation for detection. Performance evaluation is carried out on a standard matching benchmark in terms of repeat ability and matching score under different image transformations, as well as in a large scale image retrieval setup, measuring Mean Average Precision. The proposed de-scriptor is compared to the standard MSER implementation as well as a tree-based MSER implementation, achieving competitive results in the matching setup and outperforming the baseline MSER in the retrieval experiments.
Approaches to manipulating microRNAs in neurogenesis

Neurogenesis in the nervous system is regulated by both protein coding genes and non-coding RNA molecules. microRNAs (miRNAs) are endogenous small non-coding RNAs and usually negatively regulate gene expression by binding to the 3′ untranslated region (3′UTR) of target messenger RNAs (mRNAs). miRNAs have been shown to play an essential role in neurogenesis, regulating neuronal proliferation, differentiation, maturation, and migration. An important strategy used to reveal miRNA function is the manipulation of their expression levels and patterns in specific regions and cell types in the nervous system. In this review we will systemically highlight established and new approaches used to achieve gain-of-function and loss-of-function of miRNAs in vitro and in vivo, and will also summarize miRNA delivery techniques. As the development of these leading edge techniques come online, more exciting discoveries of the roles miRNAs play in neural development and function will be uncovered.
A constraint-handling mechanism for particle swarm optimization

This work presents a simple mechanism to handle constraints with a particle swarm optimization algorithm. Our proposal uses a simple criterion based on closeness of a particle to the feasible region in order to select a leader. Additionally, our algorithm incorporates a turbulence operator that improves the exploratory capabilities of our particle swarm optimization algorithm. Despite its relative simplicity, our comparison of results indicates that the proposed approach is highly competitive with respect to three constraint-handling techniques representative of the state-of-the-art in the area.
Engineering of self-assembling proteins for biosensing applications

The ability of isolated bacterial cell surface layer (S-layer) protein subunits to self-assemble into protein layers on solid surfaces makes them an almost ideal biological template for sensor oriented applications. Here, we used this remarkable property of the recombinant S-layer protein of Sporosarcina ureae bacterium to display streptavidin in defined order and orientation into two dimensional, nanosized protein lattices. We show that these lattices constitute a functional biomolecular matrix by binding biotinylated quantum dots on its surface. Therefore, they have a great application potential as sensor elements.
Recognition of the Intrinsically Flexible Addiction Antidote MazE by a Dromedary Single Domain Antibody Fragment

The Escherichia coli mazEF operon defines a chromosomal addiction module that programs cell death under various stress conditions. It encodes the toxic and long-lived MazF and the labile antidote MazE. The denaturation of MazE is a two-state reversible dimer-monomer transition. At lower concentrations the denatured state is significantly populated. This leads to a new aspect of the regulation of MazE concentration, which may decide about the life and death of the cell. Interactions of MazE with a dromedary antibody domain, cAbMaz1 (previously used as a crystallization aid), as well as with promoter DNA were studied using microcalorimetric and spectroscopic techniques. Unique features of cAbMaz1 enable a specific enthalpy-driven recognition of MazE and, thus, a significant stabilization of its dimeric native conformation. The MazE dimer and the MazE dimer-cAbMaz1 complex show very similar binding characteristics with promoter DNA, i.e. three binding sites with apparent affinities in micromolar range and highly exothermic binding accompanied by large negative entropy contributions. A working model for the MazE-DNA assembly is proposed on the basis of the structural and binding data. Both binding and stability studies lead to a picture of MazE solution structure that is significantly more unfolded than the structure observed in a crystal of the MazE-cAbMaz1 complex.
Time-Resolved Fluorescence Immunoassay for C-Reactive Protein Using Colloidal Semiconducting Nanoparticles

Besides the typical short-lived fluorescence with decay times in the nanosecond range, colloidal II/VI semiconductor nanoparticles dispersed in buffer also possess a long-lived fluorescence component with decay times in the microsecond range. Here, the signal intensity of the long-lived luminescence at microsecond range is shown to increase 1,000-fold for CdTe nanoparticles in PBS buffer. This long-lived fluorescence can be conveniently employed for time-gated fluorescence detection, which allows for improved signal-to-noise ratio and thus the use of low concentrations of nanoparticles. The detection principle is demonstrated with a time-resolved fluorescence immunoassay for the detection of C-reactive protein (CRP) using CdSe-ZnS nanoparticles and green light excitation.