Miracle-dz/UniFAR-FTUs huggingface dataset:
Decoupling design of stiffness and mass for micro shell resonator with high sensitivity

This paper proposes the decoupling design of stiffness and mass for micro shell resonator with high sensitivity using out-of-plane electrode. The resonator structure, including shell and shell edge, is primarily designed based on decoupling of effective stiffness and mass. The shell structure is built on the basis of the shell cross-sectional shape that can be designed analytically to change the effective stiffness (keff) while shell edge is just used to adjust the effective mass (Meff). The decoupling design significantly simplifies the structure design and optimization. Besides it is also flexible to adjust the dynamic parameter of the resonator by changing the geometry for high sensitivity. Out-of-plane electrode has been employed to drive and sense the spatial deformation of wineglass modes. Comparing with the conventional resonator using out-of-plane electrode, the present resonator reveals a smaller mode frequency and a 4.48 times improvement in drive amplitude, which results in superiority in sensitivity.
Anterior Segment cornea / External disorder

Causes of the Loose Lens Trauma has historically been the most common cause of a loose lens. here the term loose lens is used broadly to mean zonular dialysis (weakness). although common use of terms will vary, one early paper defines partial dislocation, or subluxation, as when the lens is still “partially in the hyaloid fossa but is displaced to one side of the optical axis”. 1 luxation (complete dislocation) is complete displacement of the lens outside the hyaloid fossa associated with complete zonular dialysis. Ectopia lentis describes a congenitally dislocated lens.2 in a series of 166 patients, trauma accounted for 53 % of cases.3 after appropriate and thorough evaluation for associated ocular injuries, other causes may be considered. isolated lens subluxation or essential ectopia lentis can spontaneously occur in adulthood.4,5 There are numerous other causes and associations including ocular diseases such as pseudoexfoliation (which in more recent studies is most common),6 myopia, or aniridia. Systemic diseases that have been reported to be associated with ectopia lentis include Marfan’s,7 Ehlersdanlos,8 Weill-Marchesani,9 sulfite oxidase deficiency,10 hyperlysinemia,11 homocystinuria,12 and syphilis.3
Three-Dimensional Integrated Circuits and the Future of System-on-Chip Designs

Three-dimensional integrated circuits (3-D ICs) offer significant improvements over two-dimensional circuits, and promise a solution to the severe problems that are being, and will be, encountered as monolithic process geometries are reduced to below 65 nm. Several methods associated with the fabrication of 3-D ICs are discussed in this paper, and the techniques developed by Tezzaron Semiconductor Corp., are described in detail. Four successful 3-D ICs are described, along with the anticipated benefits of applying 3-D design to future system-on-chip (SoC) devices.
SUPPLEMENTAL MATERIAL GPR 119 agonist AS 1269574 activates TRPA 1 cation channels to stimulate GLP-1 secretion *

GPR119 is a G protein-coupled receptor expressed on intestinal L cells that synthesize and secrete the blood glucose-lowering hormone glucagon-like peptide-1 (GLP-1). GPR119 agonists stimulate the release of GLP-1 from L cells, and for this reason there is interest in their potential use as a new treatment for type 2 diabetes mellitus. AS1269574 is one such GPR119 agonist, and it is the prototype of a series of 2,4,6 trisubstituted pyrimidines that exert positive glucoregulatory actions in mice. Here we report the unexpected finding that AS1269574 stimulates GLP-1 release from the STC-1 intestinal cell line by directly promoting Ca influx through transient receptor potential ankyrin 1 (TRPA1) cation channels. These GPR119-independent actions of AS1269574 are inhibited by TRPA1 channel blockers (AP-18, A967079, HC030031) and are not secondary to intracellular Ca release or cAMP production. Patch clamp studies reveal that AS1269574 activates an outwardly rectifying membrane current with properties expected of TRPA1 channels. However, the TRPA1 channel-mediated action of AS1269574 to increase intracellular free calcium concentration is not replicated by GPR119 agonists (AR231453, oleoylethanolamide) unrelated in structure to AS1269574. Using human embryonic kidney-293 cells expressing recombinant rat TRPA1 channels but not GPR119, direct TRPA1 channel activating properties of AS1269574 are validated. Because we find that AS1269574 also acts in a conventional GPR119-mediated manner to stimulate proglucagon gene promoter activity in the GLUTag intestinal L cell line, new findings reported here reveal the surprising capacity of AS1269574 to act as a dual agonist at two molecular targets (GPR119/ TRPA1) important to the control of L-cell function and type 2 diabetes mellitus drug discovery research. (Molecular Endocrinology 30: 614 – 629, 2016)
Differential Effects of Swedish Active Labour Market Programmes for Unemployed Adults During the 1990s

The paper evaluates the differential performance of the six main types of Swedish programmes that were available to adult unemployed workers en Titled to unemployment benefits in the 1990s: labour market training, workplace introduction, work experience placement, relief work, trainee replacement and employment subsidies. On the basis of a large and particularly rich administrative dataset, propensity score multiple-treatment matching methods are applied to investigate the differential performance of the programmes both relative to one another and vis-a-vis more intense job search in open unemployment. Outcomes being assessed are short- and long-term employment rates as well as the probability of collecting unemployment benefits over time. Compared to waiting longer in open unemployment, all the programmes initially reduce their participants' employment probability in the short term (lock- in effect). Positive findings on more long term employment prospects are confined to job subsidies alone. Participation in trainee replacement makes no difference to deputies' subsequent labour market outcomes. Individuals joining any of the remaining programmes later display either the same (workplace introduction) or lower employment rates coupled with a higher benefit collection probability than if they had searched further as openly unemployed. A likely factor behind these disappointing results is the use of such types of programmes simply as a way to requalify for unemployment benefits. As to the pair-wise comparison of the six programmes, the central finding is again that the more similar a programme is to a regular job, the higher the programme's benefits to its participants, with employment subsidies by far the best performer, followed by trainee replacement. Several macroeconomic studies have however documented large and negative displacement and dead-weight effects for exactly these types of pro-gramme, which highlights the difficult trade-off faced by labour market policy.
Self-similar spherical collapse with non-radial motions

We derive the asymptotic mass profile near the collapse center of an initial spherical density perturbation, $\delta \propto M^{-\epsilon}$, of collision-less particles with non-radial motions. We show that angular momenta introduced at the initial time do not affect the mass profile. Alternatively, we consider a scheme in which a particle moves on a radial orbit until it reaches its turnaround radius, r_*. At turnaround the particle acquires an angular momentum $L={\cal L} \sqrt{GM_* r_*}$ per unit mass, where M_* is the mass interior to r_*. In this scheme, the mass profile is $M\propto r^{3/(1+3\epsilon)}$ for all $\epsilon >0$, in the region $r/r_t\ll {\cal L}$, where r_t is the current turnaround radius. If ${\cal L} \ll 1$ then the profile in the region ${\cal L} \ll r/r_t \ll$ is $M\propto r$ for $\epsilon <2/3$. The derivation relies on a general property of non-radial orbits which is that ratio of the pericenter to apocenter is constant in a force field k(t) r^{n} with k(t) varying adiabatically.
INVESTIGATION ON SLEEPING QUALITY OF UNIVERSITY STUDENTS AND ITS INFLUENTIAL FACTORS

[Objective]To understand the quality of sleeping and its influential factors of current university students. [Methods]A self-rating scale of sleep(SRSS)and self-designed questionnaire were applied to investigate university students by stratified random sampling. [Results]52.00% students had sleeping disorders.There were no significant differences between male and female,medicine speciality and non-medicine speciality,students from city and countryside.However,there existed an significant difference among the different grades students.Health status,stresses from studying and employment,economic resource,amativeness problem,sleeping environment,and sleeping regularity could influence their sleep quality.The major investigated students had low mood,disorders of the body function(such as physical or mental status,memory,concentration and so on),and low learning efficiency in the daytime when sleeping was disturbed during the night. [Conclusion]Sleeping problems are common in university students.In order to improve the sleeping quality of university students,psychological and sleeping consults,forming a good sleeping habits,and keeping on doing exercise should be developed in the future.
Group Process and Therapeutic Protocol of Intensive Transdiagnostic Group Cognitive-Behavioral Therapy for Anxiety and Personality Disorders in a Day Clinic

ABSTRACT This brief report presents group processes and the treatment protocol of intensive, transdiagnostic group cognitive-behavior therapy for anxiety with comorbid personality disorders in a day clinic. It describes the history of and rationale for the development of this 3-month, 15-hour a week group treatment and the utilization of group processes during this therapy. The authors argue that the group format presented here allows the treatment of personality disorders that are frequently comorbid with anxiety disorders.
A speed-based approach to vestibular rehabilitation for peripheral vestibular hypofunction: A retrospective chart review

BACKGROUND: Current vestibular rehabilitation for peripheral vestibular hypofunction is an exercise-based approach that improves symptoms and function in most, but not all patients, and includes gaze stabilization exercises focused on duration of head movement. One factor that may impact rehabilitation outcomes is the speed of head movement during gaze stability exercises. OBJECTIVE: Examine outcomes of modified VOR X1 exercises that emphasize a speed-based approach for gaze stabilization while omitting substitution and habituation exercises. Balance training focused on postural realignment and hip strategy performance during altered visual and somatosensory inputs. METHODS: A retrospective chart review of 159 patients with vestibular deficits was performed and five outcome measures were analyzed. RESULTS: All outcomes – self-report dizziness and balance function, dynamic gait index, modified clinical test of sensory interaction and balance, and clinical dynamic visual acuity improved significantly and approached or achieved normal scores. CONCLUSIONS: The combination of modified VOR X1 gaze stability exercises, wherein patients achieved high-velocity head movement (240°/s) during short exercise bouts, with “forced use” gait and balance exercises for postural realignment and hip strategy recruitment, achieved 93–99% of normal scores for all five outcomes. These results compare favorably to the outcomes for current VR techniques and warrant further investigation.
Effects of a targeted shrimp (Penaeus notialis) exploitation on fish catches in the Gambia estuary

Results of an annual survey of fishing activities and catches in the Gambia estuary (200 km long), carried out from June 2001 to May 2002, indicated that fishing effort targets mainly (66% of fishing trips) shrimps. As a result of the globalisation of fish markets, the fishery has become a quasi mono-exploitation of shrimp for exporting. At the opposite, fishing activities focusing on fish were low and carried out with large and medium mesh drift nets, gill nets and surrounding nets (17% of fishing trips), handlines and longlines (15%). The annual catch, estimated at 2350 tonnes for the estuarine part of the River Gambia, consisted of 1800 t of fish and 550 t of shrimp. Stownets were the most efficient gear accounting for 50% of the total production (550 t of shrimp and 600 t of fish) while other significant techniques were mainly drift nets (21%), longlines (11%) and gillnets (5%). Fish catches were composed with 55 fish species among which 16 species accounted for 90% of the annual catch. The average catch length of these first sixteen species was 295 mm, clearly demonstrating that fishing for fish was targeting large fish. The effects of the targeted shrimp exploitation resulted in a low fishing effort for fish leading to low fish landings and consequently to an under exploitation of fish resource in the Gambia estuary.
Evaluation of Bioactive Compounds in StrawberryFruits by a Targeted Metabolomic Approach

Department of Horticultural Bioscience,Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Korea Department of Plant Bioscience, Life and Industry Convergence Research Institute, Pusan National University, Miryang 50463, Korea Gyongnam Agricultural Research and Extension Services, Jinju 52733, Korea Department of Horticulture, Gyeongsang National University, Jinju 52828, Korea
The human ear canal: investigation of its suitability for monitoring photoplethysmographs and arterial oxygen saturation

For the last two decades, pulse oximetry has been used as a standard procedure for monitoring arterial oxygen saturation (SpO2). However, SpO2 measurements made from extremities such as the finger, ear lobe and toes become susceptible to inaccuracies when peripheral perfusion is compromised. To overcome these limitations, the external auditory canal has been proposed as an alternative monitoring site for estimating SpO2, on the hypothesis that this central site will be better perfused. Therefore, a dual wavelength optoelectronic probe along with a processing system was developed to investigate the suitability of measuring photoplethysmographic (PPG) signals and SpO2 in the human auditory canal. A pilot study was carried out in 15 healthy volunteers to validate the feasibility of measuring PPGs and SpO2 from the ear canal (EC), and comparative studies were performed by acquiring the same signals from the left index finger (LIF) and the right index finger (RIF) in conditions of induced peripheral vasoconstriction (right hand immersion in ice water). Good quality baseline PPG signals with high signal-to-noise ratio were obtained from the EC, the LIF and the RIF sensors. During the ice water immersion, significant differences in the amplitude of the red and infrared PPG signals were observed from the RIF and the LIF sensors. The average drop in amplitude of red and infrared PPG signals from the RIF was 52.7% and 58.3%. Similarly, the LIF PPG signal amplitudes have reduced by 47.52% and 46.8% respectively. In contrast, no significant changes were seen in the red and infrared EC PPG amplitude measurements, which changed by +2.5% and −1.2% respectively. The RIF and LIF pulse oximeters have failed to estimate accurate SpO2 in seven and four volunteers respectively, while the EC pulse oximeter has only failed in one volunteer. These results suggest that the EC may be a suitable site for reliable monitoring of PPGs and SpO2s even in the presence of peripheral vasoconstriction.
PFunk-H: approximate query processing using perceptual models

Interactive visualization tools (e.g., crossfilter) are critical to many data analysts by making the discovery and verification of hypotheses quick and seamless. Increasing data sizes has made the scalability of these tools a necessity. To bridge the gap between data sizes and interactivity, many visualization systems have turned to sampling-based approximate query processing frameworks. However, these systems are currently oblivious to human perceptual visual accuracy. This could either lead to overly aggressive sampling when the approximation accuracy is higher than needed or an incorrect visual rendering when the accuracy is too lax. Thus, for both correctness and efficiency, we propose to use empirical knowledge of human perceptual limitations to automatically bound the error of approximate answers meant for visualization. This paper explores a preliminary model of sampling-based approximate query processing that uses perceptual models (encoded as functions) to construct approximate answers intended for visualization. We present initial results that show that the approximate and non-approximate answers for a given query differ by a perceptually indiscernible amount, as defined by perceptual functions.
Minimal Neuronal Model for the Transmission Path of Acupuncture Signal

Acupuncture has been proved to be effective for treatment of diseases, but the underlying mechanisms about acupuncture are still unknown. We design the animal experiment and process the data. We focus on the firing patterns evoked by acupuncture and developed Izhikevich neuronal model to characterize acupuncture signal. It is shown that this minimal model could account for some important experimental phenomena. Computational studies provide more insight in the underlying mechanisms of acupuncture. Keywords—Acupuncture; Izhikevich neuronal model; neural signal.
A communication characterisation of Splash-2 and Parsec

Recent benchmark suite releases such as Parsec specifically utilise the tightly coupled cores available in chip-multiprocessors to allow the use of newer, high performance, models of parallelisation. However, these techniques introduce additional irregularity and complexity to data sharing and are entirely dependent on efficient communication performance between processors. This paper thoroughly examines the crucial communication and sharing behaviour of these future applications. The infrastructure used allows both accurate and comprehensive program analysis, employing a full Linux OS running on a simulated 32-core x86 machine. Experiments use full program runs, with communication classified at both core and thread granularities. Migratory, read-only and producer-consumer sharing patterns are observed and their behaviour characterised. The temporal and spatial characteristics of communication are presented for the full collection of Splash-2 and Parsec benchmarks. Our results aim to support the design of future communication systems for CMPs, encompassing coherence protocols, network-on-chip and thread mapping.
What about Mood Swings: Identifying Depression on Twitter with Temporal Measures of Emotions

Depression is among the most commonly diagnosed mental disorders around the world. With the increasing popularity of online social network platforms and the advances in data science, more research efforts have been spent on understanding mental disorders through social media by analysing linguistic style, sentiment, online social networks and other activity traces. However, the role of basic emotions and their changes over time, have not yet been fully explored in extant work. In this paper, we proposed a novel approach for identifying users with or at risk of depression by incorporating measures of eight basic emotions as features from Twitter posts over time, including a temporal analysis of these features. The results showed that emotion-related expressions can reveal insights of individuals' psychological states and emotions measured from such expressions show predictive power of identifying depression on Twitter. We also demonstrated that the changes in an individual's emotions as measured over time bear additional information and can further improve the effectiveness of emotions as features, hence, improve the performance of our proposed model in this task.
TRPP2-dependent Ca2+ signaling in dorso-lateral mesoderm is required for kidney field establishment in Xenopus

ABSTRACT In Xenopus laevis embryos, kidney field specification is dependent on retinoic acid (RA) and coincides with a dramatic increase of Ca2+ transients, but the role of Ca2+ signaling in the kidney field is unknown. Here, we identify TRPP2, a member of the transient receptor potential (TRP) superfamily of channel proteins encoded by the pkd2 gene, as a central component of Ca2+ signaling in the kidney field. TRPP2 is strongly expressed at the plasma membrane where it might regulate extracellular Ca2+ entry. Knockdown of pkd2 in the kidney field results in the downregulation of pax8, but not of other kidney field genes (lhx1, osr1 and osr2). We further show that inhibition of Ca2+ signaling with an inducible Ca2+ chelator also causes downregulation of pax8, and that pkd2 knockdown results in a severe inhibition of Ca2+ transients in kidney field explants. Finally, we show that disruption of RA results both in an inhibition of intracellular Ca2+ signaling and of TRPP2 incorporation into the plasma membrane of kidney field cells. We propose that TRPP2-dependent Ca2+ signaling is a key component of pax8 regulation in the kidney field downstream of RA-mediated non-transcriptional control of TRPP2.
Orthogonal LDA in PCA Transformed Subspace

The paper addresses the effectiveness of orthogonal linear discriminant analysis (OLDA) in a principal component analysis (PCA) transformed subspace. The performance of the technique is studied for writer independent recognition of online handwritten Kannada numerals. Experiments show that the performance of LDA and OLDA are better in a PCA transformed subspace compared to that of the original feature space. In addition, the recognition accuracies of the system with OLDA are marginally better than that of LDA in both the original feature space and the PCA transformed subspace. An average recognition accuracy of 96.9% is achieved on a database collected from 69 writers. To our knowledge, this is the first ever reported work on recognition of online handwritten Kannada numerals.
Stem cells in sepsis and acute lung injury

Objective:Sepsis and acute lung injury continue to be major causes of morbidity and mortality worldwide despite advances in our understanding of pathophysiology and the discovery of new management strategies. Recent investigations show that stem cells may be beneficial as prognostic biomarkers and novel therapeutic strategies in these syndromes. This article reviews the potential use of endogenous adult tissue-derived stem cells in sepsis and acute lung injury as prognostic markers and also as exogenous cell-based therapy. Data Sources:A directed systematic search of the medical literature using PubMed and OVID, with particular emphasis on the time period after 2002, was done to evaluate topics related to 1) the epidemiology and pathophysiology of sepsis and acute lung injury; and 2) the definition, characterization, and potential use of stem cells in these diseases. Data Synthesis and Findings:When available, preferential consideration was given to prospective nonrandomized clinical and preclinical studies. Conclusions:Stem cells have shown significant promise in the field of critical care both for 1) prognostic value and 2) treatment strategies. Although several recent studies have identified the potential benefit of stem cells in sepsis and acute lung injury, further investigations are needed to more completely understand stem cells and their potential prognostic and therapeutic value.
Nonholonomic motion planning for car-like robots

We consider the robot motion planning problem in the presence of non-integrable kinematic constraints, known as non-holonomic constraints. Car-like non-holonomic mobile robots are used for solving this problem, and several implemented planners are discussed. We claim that the randomized methods are more capable of efficiently solving many challenging, high-dimensional problems. Results with randomized planners are very promising to extend our work applying kinodynamic motion planning.