Miracle-dz/UniFAR-FTUs huggingface dataset:
On the degree correlation of urban road networks

Recent advances in network science and the development of volunteered geographic information (VGI) have created new research opportunities in the topological analysis of road networks. The degree correlation of road networks is rarely studied. This study applied four measures, including the average degree of nearest neighbor, correlation profile, Newman's assortativity coefficient, and Litvak–Hofstad's assortativity coefficient, to measure the degree correlations of road networks represented as dual graphs of strokes, axial lines, and named roads. After investigating 100 road networks worldwide obtained from OpenStreetMap, it has been found that road networks are mostly disassortative or uncorrelated in stroke and named road representations, but assortative when represented as axial lines. Inconsistency in different measures persists regardless of method of representation; therefore, qualitative dichotomy or trichotomy is insufficient to describe the actual connection pattern in road networks. A taxonomy of road network assortativity is proposed. Two of the proposed disassortative types are associated with the absence of a grid pattern and are less robust than the typical disassortative type.
Effects of JWH015 in cytokine secretion in primary human keratinocytes and fibroblasts and its suitability for topical/transdermal delivery

Background JWH015 is a cannabinoid (CB) receptor type 2 agonist that produces immunomodulatory effects. Since skin cells play a key role in inflammatory conditions and tissue repair, we investigated the ability of JWH015 to promote an anti-inflammatory and pro-wound healing phenotype in human primary skin cells. Methods Human primary keratinocytes and fibroblasts were stimulated with lipopolysaccharide. The mRNA expression of cannabinoid receptors was determined using RT-PCR. The effects of JWH015 (0.05, 0.1, 0.5, and 1 µM) in pro- and anti-inflammatory factors were tested in lipopolysaccharide-stimulated cells. A scratch assay, using a co-culture of keratinocytes and fibroblasts, was used to test the effects of JWH015 in wound healing. In addition, the topical and transdermal penetration of JWH015 was studied in Franz diffusion cells using porcine skin and LC-MS. Results The expression of CB1 and CB2 receptors (mRNA) and the production of pro- and anti-inflammatory factors enhanced in keratinocytes and fibroblasts following lipopolysaccharide stimulation. JWH015 reduced the concentration of major pro-inflammatory factors (IL-6 and MCP-1) and increased the concentration of a major anti-inflammatory factor (TGF-β) in lipopolysaccharide-stimulated cells. JWH015 induced a faster scratch gap closure. These JWH015’seffects were mainly modulated through both CB1 and CB2 receptors. Topically administered JWH015 was mostly retained in the skin and displayed a sustained and low level of transdermal permeation. Conclusions Our findings suggest that targeting keratinocytes and fibroblasts with cannabinoid drugs could represent a therapeutic strategy to resolve peripheral inflammation and promote tissue repair.
Network patterns of legislative collaboration in twenty parliaments

In recent years, the ties that Members of Parliament (MPs) create by cosponsoring legislation together have attracted interest from scholars adopting a network approach to lawmaking. is brief note expands the empirical base of these studies by introducing a dataset of 150 bill cosponsorship networks that cover 27 parliamentary chambers from 19 European countries, plus Israel. The data show the extent of partisanship expressed by MPs through their propensity to cosponsor bills within and across party lines, in several different parliamentary systems.
UvA-DARE ( Digital Academic Repository ) Activity recognition using semi-Markov models on real world smart home datasets

Accurately recognizing human activities from sensor data recorded in a smart home setting is a challenging task. Typically, probabilistic models such as the hidden Markov model (HMM) or conditional random fields (CRF) are used to map the observed sensor data onto the hidden activity states. A weakness of these models, however, is that the type of distribution used to model state durations is fixed. Hidden semi-Markov models (HSMM) and semi-Markov conditional random fields (SMCRF) model duration explicitly, allowing state durations to be modelled accurately. In this paper we compare the recognition performance of these models on multiple fully annotated real world datasets consisting of several weeks of data. In our experiments the HSMM consistently outperforms the HMM, showing that accurate duration modelling can result in a significant increase in recognition performance. SMCRFs only slightly outperform CRFs, showing that CRFs are more robust in dealing with violations of the modelling assumptions. The datasets used in our experiments are made available to the community to allow further experimentation.
A cooperative planning algorithm to improve performance in Web domains

In this paper, we present MAPWEB, a multiagent framework that integrates planning agents and Web information retrieval agents. The goal of this framework is to deal with problems that require planning with information to be gathered from the Web. Because of flexibility and efficiency reasons, MAPWEB decouples planning from information gathering by splitting a planning problem into two parts: solving an abstract problem and validating and completing abstract solutions by means of information gathering. We focus on the planning process in order to improve its efficiency. There are two ways of improving the efficiency of the MAPWEB planning algorithm: by accelerating the planning process itself and by storing previously solved planning problems. The first has been achieved by designing a cooperative planning algorithm that allows a set of planning agents to share plans and cooperate while planning to increase efficiency. The second is currently being designed and developed to allow planning agents to reuse the acquired knowledge. Finally, this paper presents experimental evaluation of the cooperative planning process when it is used by the planning agents.
Evaluating working memory: Comparing change-detection tasks and Wechsler working memory subtests in school-age children

ABSTRACT Among a number of methods for assessing working memory (WM), span tasks have been commonly utilized in clinical psychology, whereas change-detection tasks are often used in experimental or cognitive psychology. This study sought to understand the use of change-detection tasks in children and to evaluate the relationship between change-detection tasks and clinical WM measures in the Wechsler Intelligence Scale for Children, Fourth Edition (WISC–IV). Results revealed that the overall pattern of performance in change-detection tasks for children was similar to adults’ performance in the literature; with increased array size, response accuracy systematically decreased. Significant age-related improvements on visuospatial and verbal WM capacities were found in school-age children. Although WISC–IV WM measures were significantly correlated with each other, only the Arithmetic subtest was significantly correlated with visuospatial WM as measured by the change-detection task, and none were significantly correlated with verbal WM as measured by the change-detection task. These results suggest the clinical WISC–IV WM subtests may not elicit the same construct as experimental change-detection WM measures, with the possible exception of the Arithmetic subtest.
Nonparametric Models for Uncertainty Visualization

An uncertain (scalar, vector, tensor) field is usually perceived as a discrete random field with a priori unknown probability distributions. To compute derived probabilities, e.g. for the occurrence of certain features, an appropriate probabilistic model has to be selected. The majority of previous approaches in uncertainty visualization were restricted to Gaussian fields. In this paper we extend these approaches to nonparametric models, which are much more flexible, as they can represent various types of distributions, including multimodal and skewed ones. We present three examples of nonparametric representations: (a) empirical distributions, (b) histograms and (c) kernel density estimates (KDE). While the first is a direct representation of the ensemble data, the latter two use reconstructed probability density functions of continuous random variables. For KDE we propose an approach to compute valid consistent marginal distributions and to efficiently capture correlations using a principal component transformation. Furthermore, we use automatic bandwidth selection, obtaining a model for probabilistic local feature extraction. The methods are demonstrated by computing probabilities of level crossings, critical points and vortex cores in simulated biofluid dynamics and climate data.
RELATIONSHIP BETWEEN A BAINITIC STRUCTURE AND THE HARDNESS IN THE WELD ZONE OF THE FRICTION-STIR WELDED X80 API-GRADE PIPE-LINE STEEL ODVISNOST MED BAINITNO MIKROSTRUKTURO IN TRDOTO V PODRO^JU ZVARA PRI TORNO VRTILNEM VARJENJU JEKLA X80 API ZA CEVOVODE

The present study focuses on the morphology of the weld zone, especially on the quantitative microstructural characterization of bainitic structures, and the relationship between post-weld bainitic structures and the hardness at the weld zone of the friction-stir welded X80 API-grade pipe-line steel. The employed rotating and traverse speeds of the polycrystalline cubic boron nitride tool during the friction-stir welding process were 350 r/min and 12.7 cm/min (5 inch per minute), respectively. A microstructural analysis of the weld was carried out using optical microscopy, orientation imaging microscopy and transmission electron microscopy, and the hardness variation was also mapped across the weld-plate cross section. The frictional heat and plastic flow during friction-stir welding create a granular bainitic structure (the stir zone), a lath-like upper bainitic structure (the hard zone) and a recrystallized equiaxed polygonal ferritic structure (the heat-affected zone) in the weld zone. The maximum hardness was observed in the classical upper bainitic microstructure in the hard zone. The minimum hardness was found in the heat-affected zone. A good correlation between the post-weld bainitic structures and the hardness in the weld zone was obtained; the hardness increases almost linearly with the decreasing bainite-lath and packet sizes.
Reversible Block of Mouse Neural Stem Cell Differentiation in the Absence of Dicer and MicroRNAs

Background To investigate the functions of Dicer and microRNAs in neural stem (NS) cell self-renewal and neurogenesis, we established neural stem cell lines from the embryonic mouse Dicer-null cerebral cortex, producing neural stem cell lines that lacked all microRNAs. Principal Findings Dicer-null NS cells underwent normal self-renewal and could be maintained in vitro indefinitely, but had subtly altered cell cycle kinetics and abnormal heterochromatin organisation. In the absence of all microRNAs, Dicer-null NS cells were incapable of generating either glial or neuronal progeny and exhibited a marked dependency on exogenous EGF for survival. Dicer-null NS cells assumed complex differences in mRNA and protein expression under self-renewing conditions, upregulating transcripts indicative of self-renewing NS cells and expressing genes characteristic of differentiating neurons and glia. Underlining the growth-factor dependency of Dicer-null NS cells, many regulators of apoptosis were enriched in expression in these cells. Dicer-null NS cells initiate some of the same gene expression changes as wild-type cells under astrocyte differentiating conditions, but also show aberrant expression of large sets of genes and ultimately fail to complete the differentiation programme. Acute replacement of Dicer restored their ability to differentiate to both neurons and glia. Conclusions The block in differentiation due to loss of Dicer and microRNAs is reversible and the significantly altered phenotype of Dicer-null NS cells does not constitute a permanent transformation. We conclude that Dicer and microRNAs function in this system to maintain the neural stem cell phenotype and to facilitate the completion of differentiation.
Arboreal Folivores Limit Their Energetic Output, All the Way to Slothfulness

By exploiting unutilized resources, organisms expand into novel niches, which can lead to adaptive radiation. However, some groups fail to diversify despite the apparent opportunity to do so. Although arising multiple times, arboreal folivores are rare and have not radiated, presumably because of energetic constraints. To explore this hypothesis, we quantified the field metabolic rate (FMR), movement, and body temperature for syntopic two- and three-toed sloths, extreme arboreal folivores that differ in their degree of specialization. Both species expended little energy, but three-toed sloths (162 kJ/day*kg0.734) possessed the lowest FMR recorded for any mammal. Three-toed sloths were more heterothermic and moved less than two-toed sloths. We then compared FMRs and basal metabolic rates (BMRs) for 19 species of arboreal folivores along a spectrum of specialization. Overall, arboreal folivores had lower BMRs and FMRs than other mammals, and increasing specialization led to lower FMRs but not BMRs. Thus, reduced energetic expenditure in specialized species was the result of thermoregulatory and behavioral strategies, rather than simply a proportionate reduction in BMR. Altogether, our findings support the concept that arboreal folivores are tightly constrained by nutritional energetics and help to explain the lack of radiation among species exploiting a lifestyle in the trees.
Conserved OprF as a Selective Immunogen against Pseudomonas aeruginosa

Background & Objectives: Due to the importance of Pseudomonas aeruginosa in severe inpatient infections and high mortality, the need for an efficient vaccine against these bacteria is increasing. In this regard, the general outer membrane porin of the most problematic microorganism P. aeruginosa, outer membrane protein F (OprF), is a good vaccine candidate. Methods: The databank of NCBI was used to retrieve protein sequences recorded for OprF in P. aeruginosa.The current study aimed at investigating the conservation of the OprF in 150 reference sequences, clinical, and environmental strains of P. aeruginosa from different countries via bioinformatic tools.T-COFFEE and PRALINE software were used for alignment. Results: Of these, 134 strains were isolated from clinical specimens and other strains from environmental samples. Evaluation of alignment by the mentioned software clearly showed that this protein was conserved. Antigenicity and grand average of hydropathicity were favorable. Conclusion: Conservation of OprF in all pathogenic and environmental strains of P. aeruginosa indicated that it can be considered as a good immunogen; however, the protectivity of OprF should be validated experimentally.
The Surface Sensor NlpE of Enterohemorrhagic Escherichia coli Contributes to Regulation of the Type III Secretion System and Flagella by the Cpx Response to Adhesion

ABSTRACT Although the adhesion of enterohemorrhagic Escherichia coli (EHEC) is central to the EHEC-host interaction during infection, it remains unclear how such adhesion regulates virulence factors. Adhesion to abiotic surfaces by E. coli has been reported to be an outer membrane lipoprotein NlpE-dependent activation cue of the Cpx pathway. Therefore, we investigated the role of NlpE in EHEC on the adhesion-mediated expression of virulence genes. NlpE in EHEC contributed to upregulation of the locus of enterocyte effacement (LEE) genes encoded type III secretion system and to downregulated expression of the flagellin gene by activation of the Cpx pathway during adherence to hydrophobic glass beads and undifferentiated Caco-2 cells. Moreover, LysR homologue A (LrhA) in EHEC was involved in regulating the expression of the LEE genes and flagellin gene in response to adhesion. Gel mobility shift analysis revealed that response regulator CpxR bound to the lrhA promoter region and thereby regulated expressions of the LEE genes and flagellin gene via the transcriptional regulator LrhA in EHEC. Therefore, these results suggest that the sensing of adhesion signals via NlpE is important for regulation of the expression of the type III secretion system and flagella in EHEC during infection.
Optimal Bounds for Johnson-Lindenstrauss Transformations

In 1984, Johnson and Lindenstrauss proved that any finite set of data in a high-dimensional space can be projected to a lower-dimensional space while preserving the pairwise Euclidean distance between points up to a bounded relative error. If the desired dimension of the image is too small, however, Kane, Meka, and Nelson (2011) and Jayram and Woodruff (2013) independently proved that such a projection does not exist. In this paper, we provide a precise asymptotic threshold for the dimension of the image, above which, there exists a projection preserving the Euclidean distance, but, below which, there does not exist such a projection.
Corals Use Similar Immune Cells and Wound-Healing Processes as Those of Higher Organisms

Sessile animals, like corals, frequently suffer physical injury from a variety of sources, thus wound-healing mechanisms that restore tissue integrity and prevent infection are vitally important for defence. Despite the ecological importance of reef-building corals, little is known about the cells and processes involved in wound healing in this group or in phylogenetically basal metazoans in general. A histological investigation into wound healing of the scleractinian coral Porites cylindrica at 0 h, 6 h, 24 h and 48 h after injury revealed differences in cellular components between injured and healthy tissues. Cell counts of the obligate endosymbiont, Symbiodinium, and melanin volume fraction analysis revealed rapid declines in both Symbiodinium abundance and tissue cross-sectional area occupied by melanin-containing granular cells after injury. Four phases of wound healing were identified, which are similar to phases described for both vertebrates and invertebrates. The four phases included (i) plug formation via the degranulation of melanin-containing granular cells; (ii) immune cell infiltration (inflammation); (iii) granular tissue formation (proliferation); and (iv) maturation. This study provides detailed documentation of the processes involved in scleractinian wound healing for the first time and further elucidates the roles of previously-described immune cells, such as fibroblasts. These results demonstrate the conservation of wound healing processes from anthozoans to humans.
Pressure-specific volume-temperature behavior of thermoplastics under normal processing conditions

In the processing of thermoplastics, the economy of the process and the quality of moldings are decisively influenced by material thermal properties. Therefore, it is particularly important for the processor to know and consider such properties. Process analyses have revealed that the processing conditions can be set to achieve optimum results by the application of pressure-volume-temperature diagrams, particularly if used in conjunction with computer control of the process. A new measuring instrument is described which makes it possible to determine such diagrams under normal processing conditions, that is, at normal cooling rates and pressures. The results contrast with values heretofore quoted in the literature, where values have been measured at very slow heating and cooling rates. Some experimental results and their practical use are discussed.
GrainGenes, the genome database for small-grain crops

GrainGenes, http://www.graingenes. org, is the international database for the wheat, barley, rye and oat genomes. For these species it is the primary repository for information about genetic maps, mapping probes and primers, genes, alleles and QTLs. Documentation includes such data as primer sequences, polymorphism descriptions, genotype and trait scoring data, experimental protocols used, and photographs of marker polymorphisms, disease symptoms and mutant phenotypes. These data, curated with the help of many members of the research community, are integrated with sequence and bibliographic records selected from external databases and results of BLAST searches of the ESTs. Records are linked to corresponding records in other important databases, e.g. Gramene's EST homologies to rice BAC/PACs, TIGR's Gene Indices and GenBank. In addition to this information within the GrainGenes database itself, the GrainGenes homepage at http://wheat.pw. usda.gov provides many other community resources including publications (the annual newsletters for wheat, barley and oat, monographs and articles), individual datasets (mapping and QTL studies, polymorphism surveys, variety performance evaluations), specialized databases (Triticeae repeat sequences, EST unigene sets) and pages to facilitate coordination of cooperative research efforts in specific areas such as SNP development, EST-SSRs and taxonomy. The goal is to serve as a central point for obtaining and contributing information about the genetics and biology of these cereal crops.
Preliminary Characterization and Bioactivities of Some Impatiens L. Water-Soluble Polysaccharides

Preliminary characterization and bioactivity of water-soluble polysaccharides from four Impatiens species—I. glandulifera Royle, I. parviflora DC. , I. balsamina L. , and I. noli-tangere L. —were investigated. The yields of polysaccharides range widely from 1.97% for I. parviflora roots to 18.63% for I. balsamina aerial parts. SEC (Size exclusion chromatography) chromatograms show that all samples contained a low molecular weight part that consisted of components of similar molecular weight. The aerial parts and roots of I. balsamina, and I. glandulifera aerial parts had considerable amounts of high molecular weight components up to 2.3 MDa. The sugar composition analysis revealed that Impatiens polysaccharides consisted primarily of galactose, arabinose, rhamnose, mannose, xylose, and glucose. All polysaccharide fractions, except for I. parviflora roots, also contain galacturonic acid. Moreover, in vitro bioactivity of obtained polysaccharides were evaluated. The antioxidant activity was evaluated on the basis of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino-bis-(3-ethyl-benzthia-6-sulfonic acid) (ABTS) radical scavenging assays. The highest antioxidant activity was obtained for I. balsamina aerial parts and I. parviflora roots. Among the tested fractions, only the polysaccharides from I. glandulifera aerial parts were able to significantly decrease the production of IL-8 by 32.7 ± 10.5%. The results suggest that Impatiens species can be considered as a new source of antioxidants.
Fifty years of microtubule sliding in cilia

Motility of cilia (also known as flagella in some eukaryotes) is based on axonemal doublet microtubule sliding that is driven by the dynein molecular motors. Dyneins are organized into intricately patterned inner and outer rows of arms, whose collective activity is to produce inter-microtubule movement. However, to generate a ciliary bend, not all dyneins can be active simultaneously. The switch point model accounts, in part, for how dynein motors are regulated during ciliary movement. On the basis of this model, supported by key direct experimental observations as well as more recent theoretical and structural studies, we are now poised to understand the mechanics of how ciliary dynein coordination controls axonemal bend formation and propagation.