Miracle-dz/UniFAR-FTUs huggingface dataset:
Rapid monitoring of volatile organic compounds: a comparison between gas chromatography/mass spectrometry and selected ion flow tube mass spectrometry.

RATIONALE The gold standard for monitoring volatile organic compounds (VOCs) is gas chromatography/mass spectrometry (GC/MS). However, in many situations, when VOC concentrations are at the ppmv level, there are complicating factors for GC/MS. Selected ion flow tube mass spectrometry (SIFT-MS) is an emerging technique for monitoring VOCs in air. It is simpler to use and provides results in real time. METHODS Three different experiments were used for the comparison. First SIFT-MS was applied to monitor the concentrations of 25 VOCs in a mixture at concentrations up to 1 ppmv using only a generic database for known kinetic data of three reagent ions (H3O(+), NO(+) and O2(+)) with each VOC. In experiment 2, a side-by-side comparison was made of 17 VOCs at concentrations between 1 ppmv and 5 ppbv after small corrections had been made to the SIFT-MS kinetic data. In a third experiment, a side-by-side comparison examined two groups of samples received for commercial analysis. RESULTS In experiment 1, 85% of the VOC concentrations were within 35% of their stated values without any calibration of the SIFT-MS instrument. In experiment 2, the two techniques yielded good correspondence between the measured VOC concentrations. In experiment 3, good correlation was found for VOCs from three of the samples. However, interferences from some product ions gave over-reported values in one sample from the SIFT-MS instrument. CONCLUSIONS These three experiments showed that GC/MS was better suited to monitoring samples containing large numbers of VOCs at high concentrations. In all other applications, SIFT-MS proved simpler to use, was linear with concentration over a much wider concentration range than GC/MS and provided faster results.
Selecting a Software Elicitation Technique According to Layers of Knowledge and Preciseness: A Case Study

This paper presents a case study analyzing a set of software engineering elicitation techniques. The aim of the case study is to demonstrate that completeness and preciseness are two criteria to be incorporated into the set of existing parameters used to classify and select which elicitation technique to apply depending on the project context variables. Completeness refers to how well each elicitation technique elicits domain, task and strategic requirements, and preciseness refers to how many requirements a software engineer is able to elicit using each technique. Based on the results, we can state that completeness and preciseness perform differently for each analyzed technique. Therefore, these two criteria are necessary in order to improve elicitation technique selection. Also, the techniques used in this case study have been ranked according to the above-mentioned criteria, that is, which technique included in this study, is best suited for which requirements layer and which technique can be expected to elicit most requirements during the knowledge externalization phase.
Changes to the RBA Index of Commodity Prices: 2013

This article summarises changes to be made to the RBA Index of Commodity Prices (ICP). In line with developments in export values over recent years, the weight of iron ore in the index will increase, while the weights for coal, gold and base metals will be reduced. Overall, these changes will result in minimal revisions to the ICP. Given the greater attention being paid to bulk commodities in economic assessments, the Bank will publish additional indices that will capture movements in the spot prices and average export prices of these commodities.
Use of ultrasound biomicroscopy to evaluate induced ovarian follicular growth and ovulation in mice

Recent advances in image technology, including significant gains in spatial resolution, have made realtime sequential ovarian evaluations possible in small rodents, allowing longitudinal (continued) studies of the ovarian cycle and reducing the required number of experimental animals. The aim of this study was to evaluate exogenous stimulated follicular growth in mice using high-resolution ultrasound technology. Female mice (n = 15) received a 5 IU intraperitoneal injection of equine chorionic gonadotropin (eCG) and 48 h later a 5 IU injection of human chorionic gonadotropin (hCG), and were allowed to mate thereafter. In experiment 1, animals (n = 7) were evaluated every 6 h, from 3 to 51 h after eCG injection, with an ultrasound biomicroscopy (UBM) equipped with a realtime 45 MHz microvisualization probe (RMV 707b). The ovaries were identified and follicular population quantified, and follicles were classified according to the diameter as small (≤449 μm) or large (≥450 μm). A significant change in the distribution of follicle population according to category was observed only 45 h after eCG injection (P < 0.05). In experiment 2, animals (n = 8) were evaluated every 2 h, from 2 h to 10 h after hCG treatment. The largest follicles reached a maximum size (596.7 ± 106.0 μxm) 5.8 ± 2.3 h after hCG injection. As expected, the population of large follicles decreased thereafter, indicating the progress of ovulations, but large follicles were still detected late after treatment (10.1 ± 1.1 h). In conclusion, UBM can be used to evaluate follicle dynamics in superstimulated mice (C57BL/6 and BALB/c); significant changes in follicle distribution only occur at later stages after eCG stimulation; and hCG-induced ovulations may not occur synchronously in mice.
Radiation modes investigation of Huygens source type antenna using spherical wave expansion

Spherical wave expansion (SWE) is usually used in numerous applications or analysis such as antenna measurement and physical limitations of electrically small antennas. In this paper, spherical wave expansion is used as tool to analyze the far-field radiation properties of a low profile dual-polarized wideband magneto-electric dipole antenna. The analysis demonstrates that the proposed magneto-electric antenna presents the same behavior as a generalized Huygens source with identical contribution of transverse electric (TE) and transverse magnetic (TM) modes on a wide bandwidth.
Developmental Activity of the Renin-Angiotensin System during the “Critical Period” Modulates Later L-NAME–Induced Hypertension and Renal Injury

The incidence of hypertension and hypertensive renal disease is increasing worldwide, and new strategies to prevent these diseases need to be investigated. The aims of this study were 1) to examine if transient exposure to an angiotensin receptor blocker (ARB) during an early period in hypertension development confers protection against subsequent worsening of hypertension and renal injury induced by the NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME), and 2) conversely, to examine the effects of transient exposure to angiotensin II (Ang II) during the same period. First, spontaneously hypertensive rats (SHR) were treated transiently from age 3 to 10 weeks with an ARB (candesartan cilexetil), a calcium channel antagonist or a vasodilator, then taken off treatment for 2 months. Administration of L-NAME at age 18 weeks caused severe hypertension and renal injury. However, the rats that had been exposed to the ARB not only had a lower blood pressure, but also failed to show signs of renal injury or increase of oxidative stress. Furthermore, the elevation of components of the renin-angiotensin-aldosterone system was also suppressed in these rats. In the second study, Wistar-Kyoto rats (WKY) and SHR were exposed to Ang II from age 4 to 8 weeks. The follow-up showed that the blood pressures in the WKY remained elevated compared to controls, while the SHR had heightened increases in blood pressure, renal renin mRNA, and urinary 8-hyroxydeoxyguanosine after L-NAME administration. Together, these experiments demonstrate that transient treatment of rats during an early phase in the development of hypertension with an ARB suppresses the renin-angiotensin-aldosterone system and confers long-term protection against subsequent L-NAME–induced renal injury and increases in renal oxidative stress. Conversely, developmental exposure to Ang II during this “critical” period had the opposite effect, predisposing rats to higher blood pressure, renal injury, and oxidative stress after L-NAME administration.
Appraising the Quality of Medical Education Research Methods: The Medical Education Research Study Quality Instrument and the Newcastle–Ottawa Scale-Education

Purpose The Medical Education Research Study Quality Instrument (MERSQI) and the Newcastle–Ottawa Scale-Education (NOS-E) were developed to appraise methodological quality in medical education research. The study objective was to evaluate the interrater reliability, normative scores, and between-instrument correlation for these two instruments. Method In 2014, the authors searched PubMed and Google for articles using the MERSQI or NOS-E. They obtained or extracted data for interrater reliability—using the intraclass correlation coefficient (ICC)—and normative scores. They calculated between-scale correlation using Spearman rho. Results Each instrument contains items concerning sampling, controlling for confounders, and integrity of outcomes. Interrater reliability for overall scores ranged from 0.68 to 0.95. Interrater reliability was “substantial” or better (ICC > 0.60) for nearly all domain-specific items on both instruments. Most instances of low interrater reliability were associated with restriction of range, and raw agreement was usually good. Across 26 studies evaluating published research, the median overall MERSQI score was 11.3 (range 8.9–15.1, of possible 18). Across six studies, the median overall NOS-E score was 3.22 (range 2.08–3.82, of possible 6). Overall MERSQI and NOS-E scores correlated reasonably well (rho 0.49–0.72). Conclusions The MERSQI and NOS-E are useful, reliable, complementary tools for appraising methodological quality of medical education research. Interpretation and use of their scores should focus on item-specific codes rather than overall scores. Normative scores should be used for relative rather than absolute judgments because different research questions require different study designs.
CheY-dependent Methylation of the Asparagine Receptor, McpB, during Chemotaxis in Bacillus subtilis *

For the Gram-positive organism Bacillus subtilis, chemotaxis to the attractant asparagine is mediated by the chemoreceptor McpB. In this study, we show that rapid net demethylation of B. subtilis McpB results in the immediate production of methanol, presumably due to the action of CheB. We also show that net demethylation of McpB occurs upon both additionand removal of asparagine. After each demethylation event, McpB is remethylated to nearly prestimulus levels. Both remethylation events are attributable to CheR usingS-adenosylmethionine as a substrate. Therefore, no methyl transfer to an intermediate carrier need be postulated to occur during chemotaxis in B. subtilis as was previously suggested. Furthermore, we show that the remethylation of asparagine-bound McpB requires the response regulator, CheY-P, suggesting that CheY-P acts in a feedback mechanism to facilitate adaptation to positive stimuli during chemotaxis in B. subtilis. This hypothesis is supported by two observations: a cheRBCD mutant is capable of transient excitation and subsequent oscillations that bring the flagellar rotational bias below the prestimulus value in the tethered cell assay, and the cheRBCD mutant is capable of swarming in a Tryptone swarm plate.
Modeling stress and drug craving in the laboratory: implications for addiction treatment development

Addition is a chronic relapsing illness affected by multiple social, individual and biological factors that significantly impact course and recovery of the illness. Stress interacts with these factors and increases addiction vulnerability and relapse risk, thereby playing a significant role in the course of the illness. This paper reviews our efforts in developing and validating laboratory models of stress and drug cue‐related provocation to assess stress responses and stress‐related adaptation in addicted individuals compared with healthy controls. Empirical findings from human laboratory and brain imaging studies are presented to show the specific stress‐related dysregulation that accompanies the drug‐craving state in addicted individuals. In order to adequately validate our laboratory model, we have also carefully examined relapse susceptibility in the addicted individuals and these data are reviewed. The overarching goal of these efforts is to develop a valid laboratory model to identify the stress‐related pathophysiology in addiction with specific regard to persistent craving and compulsive seeking. Finally, the significant implications of these findings for the development of novel treatment interventions that target stress processes and drug craving to improve addiction relapse outcomes are discussed.
Early error detection in systems-on-chip for fault-tolerance and at-speed debugging

In this paper we propose a new method for the design of duplex fault-tolerant systems with early error detection and high availability. All the scannable memory elements (flip-flops) of the duplicated system are implemented as multimode memory elements according to Singh et al. (1999), thus allowing during normal operation the accumulation of a signature of its states in its scan-paths. By continuously comparing a 1-bit sequence of the compacted scan-out outputs of the accumulated signatures of the duplicated systems an error can be already detected and a recovery procedure started before an erroneous result appears at the system outputs when a computations is completed. The accumulation of a signature during normal operation can also be used for debugging at-speed. For this application the system need not be duplicated.
Microbicide safety/efficacy studies in animals: macaques and small animal models

Purpose of reviewA number of microbicide candidates have failed to prevent HIV transmission in human clinical trials, and there is uncertainty as to how many additional trials can be supported by the field. Regardless, there are far too many microbicide candidates in development, and a logical and consistent method for screening and selecting candidates for human clinical trials is desperately needed. The unique host and cell specificity of HIV, however, provides challenges for microbicide safety and efficacy screening, that can only be addressed by rigorous testing in relevant laboratory animal models. Recent findingsA number of laboratory animal model systems ranging from rodents to nonhuman primates, and single versus multiple dose challenges have recently been developed to test microbicide candidates. These models have shed light on both the safety and efficacy of candidate microbicides as well as the early mechanisms involved in transmission. This article summarizes the major advantages and disadvantages of the relevant animal models for microbicide safety and efficacy testing. SummaryCurrently, nonhuman primates are the only relevant and effective laboratory model for screening microbicide candidates. Given the consistent failures of prior strategies, it is now clear that rigorous safety and efficacy testing in nonhuman primates should be a prerequisite for advancing additional microbicide candidates to human clinical trials.
Changes of plantar pressure distributions following open and closed kinetic chain exercise in patients with stroke.

OBJECTIVE The aim of this study is to investigate whether progressive resistive training with closed-kinetic chain (CKC) and open-kinetic chain (OKC) exercises could change plantar pressure distribution during walking in patients with stroke. METHODS Thirty-nine stroke patients were recruited and randomly divided into a CKC exercise group (n = 13), an OKC exercise group (n = 13), and a control group (n = 13). Both CKC and OKC exercise groups performed their own respective training programs 5 times per week for 6 weeks, whereas no training was done in the control group. Barefoot plantar pressure distribution was measured during walking in terms of contact area (CA), peak contact force (PCF), and contact impulse (CI) on each of three foot regions (i.e. forefoot (FF), midfoot (MF), and hindfoot (HF)). RESULTS In the CKC exercise group, there were significant changes in only the CA and PCF of HF. In the OKC exercise and control groups, no significant differences were found for all variables of plantar pressure distributions. CONCLUSION We found that resistive training with closed kinetic chain exercises could be an effective treatment method for improving normal gait patterns in stroke patients. These findings may be attributed to the fact that CKC exercise induced use of the ankle and knee muscles and provided repetitive sensory input from the affected foot.
Treatment of severe edema in children with nephrotic syndrome with diuretics alone--a prospective study.

BACKGROUND AND OBJECTIVE Severe edema in children with nephrotic syndrome (NS) may be associated with volume contraction (VC) or volume expansion (VE). Usually, severe edema in children is treated with intravenous (IV) albumin and diuretics, which is appropriate for VC patients. However, in VE patients, this can precipitate fluid overload. The objective of this study was to evaluate treatment of severe edema in NS with diuretics alone. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Thirty NS patients with severe edema were enrolled in this prospective study in two phases. VC was diagnosed based on fractional excretion of sodium (FeNa) <1%. VC patients received IV albumin and furosemide. VE patients received IV furosemide and oral spironolactone. On the basis of phase 1 observations, FeNa <0.2% identified VC in 20 phase 2 patients. RESULTS All phase 1 patients had FeNa <1%. Phase 1 patients when reanalyzed based on a FeNa cutoff of 0.2%; it was noted that VC patients had higher BUN, BUN/creatinine ratio, urine osmolality, and lower FeNa and urine sodium compared with VE patients. Similar results were observed in phase 2. VC patients had significantly higher renin, aldosterone, and antidiuretic hormone levels. In phase 2, 11 VE patients received diuretics alone and 9 VC patients received albumin and furosemide. There was no difference in hospital stay and weight loss in VC and VE groups after treatment. CONCLUSIONS FeNa is useful in distinguishing VC versus VE in NS children with severe edema. The use of diuretics alone in VE patients is safe and effective.
Ultrasound imaging of the serratus anterior muscle at rest and during contraction

The purpose of this study is to describe a clinically feasible method for measuring the thickness of the serratus anterior (SA) muscle using rehabilitative ultrasound imaging (RUSI) and to determine the reliability of repeated measures of that method. An exploratory clinical measurement study using a test–retest methodology was utilized to determine the reliability of the measurements in a sample of 20 healthy subjects. While sitting with the arm flexed 120°, the SA of each subject was imaged at rest, during an active hold and while holding a three pound weight. On Day 1, images were repeated three times for each condition by the same examiner. On Day 2, Examiner 1 and Examiner 2 repeated the scans. Images were examined offline by Examiner 1 with SA thickness measured superior to the most distal rib in the image. Reliability was evaluated using intraclass correlation coefficients (ICCs) and Bland–Altman plots. The intra‐examiner reliability (same day) during rest, active hold and active hold with resistance was ICC3,3 = 0·892; ICC3,3 = 0·951; and ICC3,3 = 0·869–0·971, respectively. Intra‐examiner reliability between days ranged from ICC3,2 = 0·613 at rest to ICC3,2 = 0·736 during active hold with resistance. Interexaminer reliability was moderate during active hold (ICC2,2 = 0·526) and active hold with resistance (ICC2,2 = 0·535) and poor during rest (ICC2,2 = 0·425). This study demonstrates that SA thickness can be measured reliably using RUSI by the same examiner and suggests that active movements may increase that reliability.
Analysis of data structures and exploration techniques applied to large 3D marine structures using UAS

This paper is focused on the analysis and comparison of different data structures for 3D space representation in autonomous exploration of large marine structures with UAS. The classical and widely used frontier exploration approach is applied: the frontier cells, which are the locations in the world representation map that are explored and unoccupied but has unexplored space in its vicinity, are of particular interest as they yield the highest information gain. Thus, the data structures have been compared from the point of view of their performance to be applied in the frontier exploration approach. The same algorithm has been run for the different data structures under different scenarios, both with synthetic and real datasets gathered with an UAS. The results are analyzed in detail taking into account the amount of iterations required and the number of computed frontier cells.
Integrated cmos rectifier for rf-powered wireless sensor network nodes

This article presents a review of the CMOS rectifier for radio frequency energy harvesting application. The on-chip rectifier converts the ambient low-power radio frequency signal coming to antenna to useable DC voltage that recharges energy to wireless sensor network (WSN) nodes and radiofrequency identification (RFID) tags, therefore the rectifier is the most important part of the radio frequency energy harvesting system. The impedance matching network maximizes power transfer from antenna to rectifier. The design and comparison between the simulation results of one- and multi-stage differential drive cross connected rectifier (DDCCR) at the operating frequencies of 2.44GHz, and 28GHz show the output voltage of the multi-stage rectifier doubles at each added stage and power conversion efficiency (PCE) of rectifier at 2.44GHz was higher than 28GHz. The (DDCCR) rectifier is the most efficient rectifier topology to date and is used widely for passive WSN nodes and RFID tags.
R2: Random Push with Random Network Coding in Live Peer-to-Peer Streaming

In information theory, it has been shown that network coding can effectively improve the throughput of multicast communication sessions in directed acyclic graphs. More practically, random network coding is also instrumental towards improving the downloading performance in BitTorrent-like peer-to-peer content distribution sessions. Live peer-to-peer streaming, however, poses unique challenges to the use of network coding, due to its strict timing and bandwidth constraints. In this paper, we revisit the complete spectrum in the design space of live peer-to-peer streaming protocols, with a sole objective of taking full advantage of random network coding. We present R2, our new streaming algorithm designed from scratch to incorporate random network coding with a randomized push algorithm. R2 is designed to improve the performance of live streaming in terms of initial buffering delays, resilience to peer dynamics, as well as reduced bandwidth costs on dedicated streaming servers, all of which are beyond the basic requirement of stable streaming playback. On an experimental testbed consisting of dozens of dual-CPU cluster servers, we thoroughly evaluate R2 with an actual implementation, real network traffic, and emulated peer upload capacities, in comparisons with a typical live streaming protocol (both without and with network coding), representing the current state-of-the-art in real-world streaming applications.