Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Paclitaxel and Heparin on Vitality, Proliferation and Cytokine Production of Endometrial Cancer Cells

Abstract Background Cancer patients have a higher risk for thromboembolic events compared to healthy individuals and are often treated with heparins. A beneficial effect of heparins on tumor patients above and beyond the classic anticoagulation effect has been reported, leading to an increased focus on the use of heparins in anticancer treatment. In recent years, it has become apparent that microenvironments greatly affect tumor development and can be a major source of tumor-promoting factors. Cytokines play an important role in tumor microenvironments, inducing carcinogenesis and influencing tumor progression by promoting angiogenesis, metastatic potential and immunosuppression. The possible interaction of heparins and cytokines could also have an effect on cancer cells. Methods This study investigated the effect of paclitaxel (PTX) combined with heparins on the vitality of endometrial cancer cells using viability and cytotoxicity assays. The study also examined whether treatment with paclitaxel and heparin influences cytokine secretion or expression. Results Heparin treatment did not influence cell viability, and no influence of heparins in combination with paclitaxel was seen for the evaluated cancer cell lines HEC-1-A, KLE, RL 95-2 and AN3-CA compared to untreated cells. Secretion of the cytokines CCL5, CCL2 and IL-6 increased after paclitaxel treatment in several endometrial cancer cell lines, but no general effect on cytokine secretion was detected after heparin treatment. A significant decrease in CCL5 expression was only detected in KLE cells following treatment with heparin and paclitaxel, and an increase in the expression of CCL5 in RL 95-2 cells. Conclusion Further in-depth studies are needed to investigate the functions of cytokines CCL2, CCL5 and IL-6 in endometrial cancer cells treated with paclitaxel. Although no general effect on cytokine secretion was detected following heparin treatment, a selective modulatory impact could exist.
Feature bandwidth extension for Persian conversational telephone speech recognition

Configuring a whole setup with application of continuous conversational telephony speech recognition in Persian is the goal of this paper. For this propose, two common methods, Gaussian Mixture Model (GMM) and Neural Network (NN) and a proposed hybrid GMM-NN method have been considered to estimate full-bandwidth features from band-limited features. Performances of these methods have been evaluated with two different spectral and cepstral based features, LFBE and MFCC. Also, the effect of speaker gender in estimation process has been investigated. Our results showed that best phoneme recognition accuracy is obtained when MFCC features are reconstructed using two gender dependent neural networks. In this configuration, phoneme accuracy was about 1.6 % more than baseline. The tests were applied on TFarsDat corpus.
A study of breast motion using non-linear dynamic FE analysis

This paper presents a new method to simulate non-linear breast motion by using a three-dimensional (3D) dynamic finite element model (FEM). The model consists of a thorax with two breasts and three skin layers with specific mechanical properties. Using free breast vibration, the viscous damping ratios were ascertained to be 0.215 for an 80B size breast. The shear modulus for the breast was derived as the value that gave the minimum difference between the FEM-predicted results and the experimental data. A hyper-elastic neo-Hookean material model simulated the large deformation of breast tissue. The mode shapes of breast motions at different natural frequencies were established. The highest breast displacement amplitude ratio relative to the thorax was at 4 Hz. The study showed that FEM can predict breast displacement with sufficient accuracy and thereby provide the basis by which bras may be engineered more ergonomically in the future. Practitioner Summary: To facilitate a theoretical analysis of breast motion to enable the design of more supportive bras, a dynamic FEM based on reliable non-linear properties of breast tissues has been developed. The methods and findings have potential widespread benefit for developing new products to promote women's health and comfort.
Intraspecific trait variants determine the nature of interspecific interactions in a habitat-forming species.

Although the study of ecological interactions often takes into account functional variation between species, intraspecific variation is commonly ignored. Here, we investigate the importance of an intraspecific polymorphism in shaping interspecific interactions in a habitat-building species. Colonies of the social spider Anelosimus studiosus provide habitat for dozens of arthropod species, and colony members exhibit markedly polymorphic behavioral temperaments (BT): "aggressive" or "docile. " We manipulated the phenotypic compositions of colonies (100% aggressive, 50% aggressive and 50% docile, 100% docile) and measured the nature and magnitude of interactions between A. studiosus and two heterospecific web associates, Larinioides cornutus and Agelenopsis emertoni. We found that BT composition significantly affected the outcome of interspecific interactions, changing the relationship between A. studiosus and its web associates from an ammensalism (where A. studiosus experiences reduced fecundity and survival) to a commensalism or mutualism. Our study successfully illustrates the potential of BTs to impact whole community dynamics, and conversely, for community structure to influence the maintenance of BTs.
Registered 3-D Ultrasound and Digital Stereotactic Mammography for Breast Biopsy Guidance

Large core needle biopsy is a common procedure used to obtain histological samples when cancer is suspected in diagnostic breast images. The procedure is typically performed under image guidance, with freehand ultrasound and stereotactic mammography (SM) being the most common modalities used. To utilize the advantages of both modalities, a biopsy device combining three-dimensional ultrasound (3DUS) and digital SM imaging with computer-aided needle guidance was developed. An implementation of a stereo camera method was applied to SM calibration, providing a target localization error of 0.35 mm. The 3D transformation between the two imaging modalities was then derived, with a target registration error of 0.52 mm. Finally, the needle guidance error of the device was evaluated using tissue-mimicking phantoms, showing a sample mean and standard deviation of and 0.49 plusmn 0.27 mm for targets planned from 3DUS and SM images, respectively. These results suggest that a biopsy procedure guided using this device would successfully sample breast lesions at a size greater than or equal to the smallest typically detected in mammographic screening (~2mm).
Evaluation of an automated extraction method for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae by Cobas Amplicor PCR from different sample materials

A commercially available automated device (MagNA Pure LC™) was adapted for nucleic acid extraction of urogenital specimen for subsequent PCR detection of Chlamydia trachomatis and Neisseria gonorrhoeae in a clinical laboratory. Results were compared to the standard manual extraction procedure and showed excellent correlation, with even slightly increased sensitivity.
Sequence Polymorphism and PCR-Restriction Fragment Length Polymorphism Analysis of the Flagellin Gene of Burkholderia pseudomallei

ABSTRACT Four flagellin allelic types (I to IV) of Burkholderia pseudomallei were identified based on their sequence variation and restriction fragment length polymorphism (RFLP) analysis of the amplified flagellin gene. Flagellin allelic type I was the most predominantly (75.0%) found among the 100 clinical isolates of B. pseudomallei investigated in this study.
The three-dimensional structure of the vnd/NK-2 homeodomain-DNA complex by NMR spectroscopy.

The three-dimensional solution structure obtained by NMR of the complex formed between the uniformly singly15N and doubly13C/15N-labeled vnd/NK-2 homeodomain and its consensus 16 base-pair DNA binding sequence was determined. This work was carried out using the accepted repertoire of experiments augmented with a novel implementation of the water flipback technique to enhance signals from exchangeable amide protons. The results using this new technique confirm the existence of hydrogen bonding between the invariant Asn51 and the second adenine of the DNA binding sequence, as seen in crystal structures of other homeodomain-DNA complexes, but never before detected by NMR. Hydrogen bonding by Arg5 and Lys3 in the minor groove of the DNA appears to be responsible for two unusually upfield-shifted ribose H1' resonances. The DNA duplex is nearly straight and its structure is primarily that of B -DNA. A detailed comparison is presented for all available homeodomain-DNA structures including the vnd/NK-2 DNA complex, which demonstrates that homology is maintained in the protein structure, whereas for the orientation of the homeodomain relative to DNA, small but significant variations are observed. Interactions are described involving certain residues in specific positions of the homeodomain, namely Leu7, Thr41, and Gln50 of vnd/NK-2, where single amino acid residue mutations lead to dramatic developmental alterations. The availability of our previously determined three- dimensional structure of the vnd/NK-2 homeodomain in the absence of DNA allows us to assess structural changes in the homeodomain induced by DNA binding.
Contagion between Markets During Financial Crises

In this work we investigate how a number of crises have affected most of the stock markets in the world. First, we apply Time Series Factors Analysis (TSFA) in order to reduce the dimensionality of the series under study and obtain a lower number of factors that can be related to regions. Then we use the dynamic conditional correlation (DCC) model to obtain the pair-wise correlations between regions. Finally, we analyse the effect of the different crisis on correlations. This approach allows us to detect contagion between markets during the most important crisis. Our results show evidence of a contagion effect between most regions.
Citizenship Behaviors Perceptions of Authentic Leadership and Their Withdrawal and Psychological Empowerment as a Mediator Between Teachers

Purpose: This study explores the mediating role of psychological empowerment on authentic leadership, organizational citizenship behaviors (OCB), and a variety of withdrawal behaviors among teachers, using the psychological model of perceptions-attitudes-behaviors. Research Design: A total of 366 teachers from 23 randomly selected Israeli schools participated in the study. The research combined self-reports and school records taken at regular time intervals regarding three withdrawal behaviors: lateness, absenteeism, and intent to leave. The model for the hierarchical data (teachers within schools) that included latent as well as manifest variables was analyzed using the Mplus statistical package applying to multilevel analysis. Findings: “Impact,” a dimension of psychological empowerment, was found to mediate the relationship between authentic leadership and OCB, whereas “self-determination, meaning, and competence,” the other 1Bar-Ilan University, Ramat-Gan, Israel Corresponding Author: Orly Shapira-Lishchinsky, Department of Educational Administration, Leadership and Policy, School of Education, Bar-Ilan University, Ramat-Gan 52900, Israel. Email: Shapiro4@mail.biu. ac.il 513898 EAQXXX10.1177/0013161X13513898Educational Administration QuarterlyShapira-Lishchinsky and Tsemach research-article2014 at University of Haifa Library on February 17, 2014 eaq.sagepub. com Downloaded from 2 Educational Administration Quarterly dimension of psychological empowerment, was found to mediate the relationship between authentic leadership and absence frequency. No mediating relationship was found for psychological empowerment on authentic leadership and the other withdrawal behaviors of lateness and intent to leave. Research Implications: The present study improves the Ajzen and Fishbein model. While most previous withdrawal behavior studies focused on a single dimension of withdrawal behaviors and did not consider OCB, the present study presents an integrative framework, focusing on the mediating role of psychological empowerment as a consistent link between authentic leadership and a spectrum of teachers’ withdrawal behaviors and OCB. Practical Implications: These findings should encourage principals to promote high standards of authentic leadership to empower their teachers, increase OCB, and reduce absenteeism among teachers.
GaN MMIC broadband Doherty power amplifier

A quarter-wavelength transformer, phase compensation network, offset line are the bandwidth limiting factors of Doherty PAs. In this paper, we expand the bandwidth of the Doherty PA by employing a new structure. The conventional phase compensation network is merged into an input matching circuit and the offset line is resonated-out by an inductor. The quarter wavelength transformer has a low-Q characteristic compared to that of conventional one. With the proposed topology, a broadband Doherty PA is implemented using TriQuint 3MI 0. 25μm GaN-HEMT MMIC process. Across 2.1-2.7 GHz, the implemented PA delivered a DE of over 40.5%, a gain of over 11.8 dB and ACPR of below -45dBc at an average power of over 33.2 dBm for LTE signal with a 6.5 dB peak-to-average power ratio. This fully integrated circuit has a chip-size of 3.5mm by 1.9mm.
STn and Prognosis in Breast Cancer

Sialyl-Tn (STn) is a carbohydrate antigen formed by the premature 2–6 sialylation of N-acetylgalactosamine. It belongs to a family of antigens widely expressed in carcinomas but only to a limited degree in normal tissue. The expression of STn has been associated with prognosis in different tumors. In this immunohistochemical study of 218 patients with invasive stage I–III breast cancer, STn was expressed in 39% of the tumors. High expression of STn correlated with estrogen and progesterone hormone receptor negativity (p = 0.0002 and p = 0.0003, respectively), and marginally with large tumor size (p = 0.04), high S-phase fraction (p = 0.04) and aneuploidy (p = 0.04), but not significantly with node status, grade or age. The patients had a median follow-up of 17 years. The breast-cancer-specific survival rate of patients with STn-negative cancers was higher than that of patients with cancers that expressed STn during the first 5 years of the follow-up (p = 0.013), but the difference between the groups decreased during the long-term follow-up. STn expression seems to be a marker for short-term, but not for long-term breast cancer outcome prediction.
The distributed generator placement and sizing test suite and analysis tool

The concept of integrating small-scale embedded generators into the distribution system has been gaining increasing traction in the research community and with it has come a growing set of contemporary works from the field of artificial intelligence. Thus far however, the studies have failed to explore a diverse set of problems, lack analytical rigour, offer scant comparison between approaches and often fail to use models based on real-world loads or generators. This work describes the new DG PAST SAT software, which is freely available, open to community input and features a rich repository of distribution system resources and a comprehensive test problem suite. When coupled with included analysis utilities, the DG PAST SAT system provides the tools and data for improved research quality in the distribution system planning phase.
High growth and rising inequality in Kerala since the 1980s

Abstract Over the last three decades, the state of Kerala in South India has witnessed fast-paced growth, with the highest recorded inequality (in 2009–2010) among all the states in India; however, its human development indicators remain the highest in India. This marks a departure from the well-known development trajectory of Kerala – famously known as the Kerala model – of low growth and moderate inequality with high human development indicators. We conduct GDP and growth decomposition, inequality decomposition and a Marxian class analysis of the National Sample Survey data from Kerala in order to understand these recent phenomena. While the notion that economic liberalization adopted by the state and central governments is the main cause of this new state of affairs is generally valid, we provide a more nuanced account of the causal structures based on class analysis and the impact of outward labour migration to the Persian Gulf.
Designing mobile augmented reality experiences using friendly markers

This paper discusses an approach for in-situ creation of augmented reality experiences using friendly markers. We introduce the notion of friendly markers and how we have empirically defined it. A mobile application is built for users to turn the physical markers into augmented reality experiences. The application enables users to recognize and interact with friendly markers. The bottleneck of marker recognition on a mobile device was overcome through a multiphase browsing experience which separates discovery and recognition of markers. A formative evaluation, conducted with 12 participants, shows the success of our approach in providing instant access to augmented reality experiences. The evaluation highlights several usability concerns when registering markers; nonetheless, it shows users' excitement about designing their own digital experiences for the real world.
SANB-- Bb-/ I 3 7 L A Graph-Based System for Network-Vulnerability Analysis C o w9 8 059 f--

O S T I This paper presents a graph-based approach to network vulnerability analysis. The method is flexible, allowing analysis of attacks from both outside and inside the network. It can analyze risks to a specific network asset, or examine the universe of possible consequences following a successful attack. The graph-based tool can identify the set of attack paths that have a high probability of success (or a low “effort” cost) for the attacker. The system could be used to test the effectiveness of making configuration changes, implementing an intrusion detection system, etc. The analysis system requires as input a database of common attacks, broken into atomic steps, specific network configuration and topology information, and an attacker profile. The attack information is “matched” with the network configuration information and an attacker profile to create a superset attack graph. Nodes identify a stage of attack, for example the class of machines the attacker has accessed and the user privilege level he or she has compromised. The arcs in the attack graph represent attacks or stages of attacks. By assigning probabilities of success on the arcs or costs representing level-of-effort for the attacker, various graph algorithms such as shortest-path algorithms can identify the attack paths with the highest probability of success. Sandia is a multipiogram laboratory opcrated by Sandia Corporation, a Lockhecd Martin Conipany, for the United States Department of Energy under contract DE-ACO4-94hL85000.
Impact of Febuxostat on Renal Function in Gout Patients With Moderate‐to‐Severe Renal Impairment

Renal impairment is a risk factor for gout and a barrier to optimal gout management. We undertook this exploratory study to obtain data that have been heretofore limited regarding the safety and efficacy of febuxostat in patients with moderate‐to‐severe renal impairment (estimated glomerular filtration rate [GFR] 15–50 ml/minute/1.73 m2).
Phadiatop Infant® detects IgE‐mediated diseases among pre‐school children: a prospective study

To cite this article: Nilsson C, Lilja L, Nordlund M, Berthold M, Borres MP. Phadiatop Infant® detects IgE‐mediated diseases among pre‐school children: a prospective study. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399‐3038.2011. 01203.x
Diagnostic Accuracy of Nasopharyngeal Swabs in Detecting Biofilm-Producing Bacteria in Chronic Adenoiditis

Objectives. Biofilms are organized bacterial communities that are playing an increasing role in otolaryngological diseases such as chronic or recurrent middle ear otitis and adenotonsillitis. Various cultural techniques are available to detect biofilm-producing bacteria (BPB), but microbiological analysis of bioptic staining is the reference diagnostic procedure. To our knowledge, the accuracy of nasopharyngeal swabs in diagnosing BPB has never been assessed. Study Design. A prospective study of diagnostic accuracy. Setting. Outpatient clinics of the Departments of Specialist Surgical Sciences and Maternal and Pediatric Sciences, University of Milan, Italy. Subjects and Methods. Forty-two pediatric subjects with chronic adenoiditis (aged 4-18 years) underwent adenoidectomy, during which multiple transoral nasopharyngeal swabs and adenoidal biopsies were performed. BPB were detected by spectrophotometry, and the accuracy of detecting BPB in nasopharyngeal swabs was compared with that of biopsy. Results. BPB were detected in 73.8% of the nasopharyngeal swabs and in 69.1% of the biopsies. The sensitivity and specificity of the nasopharyngeal swabs were, respectively, 75.9% (95% confidence interval [CI], 60.3%-91.4%) and 30.8% (95% CI, 5.7%-55.9%); positive and negative predictive values were, respectively, 71.0% (95% CI, 55.0%-86.9%) and 36.4% (95% CI, 7.9%-64.8%); and the area under the receiver-operating characteristic curve was 0.5 (95% CI, 0.4-0.7). Conclusions. In comparison with biopsy, nasopharyngeal swabs seem to be inaccurate in detecting BPB and should be cautiously used in clinical practice. As these preliminary findings may have been due to the well-known resistance of biofilm to mechanical injuries (such as swab rubbing) or the small study population, they need to be confirmed in larger patient series.
BASIC MATHEMATICAL MODELS IN ECONOMIC-ECOLOGICAL CONTROL UDC 51-7 : 33

This paper is devoted to the application of the general principles of mathematical modeling to such a specific area as economic-environmental interaction. For the description of some of these models we use results and algorithms from [5] and [6]. In [7], [8] and [9] some of these mathematical models are used in the analysis of Pareto optimality and external effects in ecology.
Children's Influence on Purchasing Tourism Products via the Internet: Parental Power Versus children's Power—the Social Power Perspective

ABSTRACT An integration of the social power theory, which simultaneously incorporates parental power and children's power into the framework, was used in this research to investigate the causal relationships among perceived parental power, adolescent Internet mavens, and children's influence on purchasing tourism products via the Internet. The cluster sampling approach was used to collect samples from three tutoring schools in Taiwan. A total of 266 student-parent questionnaires was analyzed. The results show that both perceived parental power and adolescent Internet mavens are critical antecedents of children's influence on purchasing tourism products via the Internet. The results also indicate that adolescent Internet mavens exert moderating effects between perceived parental power and children's influence. These findings have managerial implications and provide useful reference data for future research.