Miracle-dz/UniFAR-FTUs huggingface dataset:
Syntaxin4 Interacting Protein (Synip) Binds Phosphatidylinositol (3,4,5) Triphosphate

The insulin responsive Glut4 transport vesicles contain the v-SNARE protein Vamp2 that associate with the plasma membrane t-SNARE protein Syntaxin 4 to drive insulin-stimulated Glut4 translocation in skeletal muscle and adipocytes. The syntaxin 4 interacting protein (Synip) binds to syntaxin 4 in the basal state and dissociates in the insulin-stimulated state allowing for the subsequent binding of Vamp2 containing Glut4 vesicles and fusion with the plasma membrane. In this study, we have found that Synip binds phosphatidylinositol 3,4,5-triphosphate (PIP3), but not phosphatidylinositol 3 phosphate (PIP) or phosphatidylinositol 3,4-biphosphate (PIP2) through the Synip WW domain as deletion of this domain (Synip ΔWW) failed to bind PIP3. Over-expressed Synip ΔWW in 3T3L1 adipocytes reduced the basal levels of Glut4 at the plasma membrane with no effect on the binding to syntaxin 4 in vitro. Subcellular fractionation demonstrated that the amount of Synip ΔWW at the PM was decreased in response to insulin in 3T3L1 adipocytes whereas the amount of Synip WT increased. These data suggest that in the presence of insulin, the dissociated Synip remains anchored to the plasma membrane by binding to PIP3.
ABO blood group and secretor status in relation to clinical characteristics of peptic ulcers

EDITORIAL SYNOPSIS A large series of peptic ulcer patients divided into groups according to those who bled, those who required operation, and those who had neither bleeding nor operation showed a dissociation between ABO blood group and secretor status. Patients who had undergone operation showed a higher proportion of non-secretors for both gastric and duodenal ulcers than others. Ulcer patients who bled showed an increased frequency of blood group 0 compared with the others, but there was no difference as between the operation and non-operation groups. A careful statistical analysis of results and review of previous work on this subject makes the findings in this paper important, particularly as a possible guide to prognosis. Possible relationships between genetic factors and ulcer prognosis
Hope and Despair: Southern Black Women Educators Across Pre- and Post-Civil Rights Cohorts Theorize about Their Activism

Framed by theoretical perspectives on Black Feminist Thought, the life course, and the Generation X/Hip-Hop generation, I present findings from a subset of 10 Black women educators in Birmingham, Alabama who participated in a larger life story project. The participants, who came of age professionally across the pre- and post-civil rights movement (CRM), describe divergent and convergent social and historical contexts that shaped their professionalization, as well as their relationships with and perceptions of Black students and parents. Participants across generation theorize that teaching and leading are activist practices in their own right, which entail clandestine support and silent protest, intergenerational bridge-building, and debunking the myth of Black inferiority. Post-CRM educators, in particular, expressed ambivalence about their urban students’ futures. I conclude that multigenerational perspectives should figure more prominently in the scholarship on Black education in the US South. This emphasis could spark new directions and strategies for linking successive generations of Black educators, thereby maximizing opportunities for intergenerational dialogue and collaboration for transformative change in urban education.
A Functioning Adrenocortical Oncocytoma

Woo Seok Oh, Jae Wook Chung, Joon Beom Kwon, Tae Gyun Kwon, Jeong Sik Kim, Gil Sook Yoon From the Departments of Urology and Pathology, School of Medicine, Kyungpook National University, Daegu, Korea Adrenocortical oncocytomas are exceptionally rare and most are benign and nonfunctioning. Only 3 cases of adrenal oncocytomas have been reported in the Korean literature and all of them were nonfunctioning. Herein, we report a case of a functioning adrenocortical oncocytoma in a 49-year-old man who presented with Cushing syndrome. (Korean J Urol 2009;50:401-403) 󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏
Mineralogy of a Mudstone at Yellowknife Bay, Gale Crater, Mars

Sedimentary rocks at Yellowknife Bay (Gale crater) on Mars include mudstone sampled by the Curiosity rover. The samples, John Klein and Cumberland, contain detrital basaltic minerals, calcium sulfates, iron oxide or hydroxides, iron sulfides, amorphous material, and trioctahedral smectites. The John Klein smectite has basal spacing of ~10 angstroms, indicating little interlayer hydration. The Cumberland smectite has basal spacing at both ~13.2 and ~10 angstroms. The larger spacing suggests a partially chloritized interlayer or interlayer magnesium or calcium facilitating H2O retention. Basaltic minerals in the mudstone are similar to those in nearby eolian deposits. However, the mudstone has far less Fe-forsterite, possibly lost with formation of smectite plus magnetite. Late Noachian/Early Hesperian or younger age indicates that clay mineral formation on Mars extended beyond Noachian time.
Through the wardrobe: Women’s relationship with their clothes

Relating to clothes is a fundamental experience in the lives of most Western women. Even when choice is fraught with ambivalence, clothing matters. From considerations about dressing for success, to worries about weight, through to investing particular articles of clothing with meaning bordering on the sacred, what we wear speaks volumes about personal identity - what is revealed, what is concealed, what is created. This book fills a gap in the existing literature on the ambivalence of fashion and dress by drawing on a wide range of women's experiences with their wardrobes and providing empirical data noticeably absent from other studies of women and dress. Navigating what is clearly a contested realm in feminist scholarship, contributors provide rich case studies of the reality of women's relationships with clothing. While on the surface concerns about fashion or dress may appear to reflect gendered patterns, in fact clothing may be used to challenge ascribed meanings about femininity.
Nuclear Angiocardiography in the Diagnosis of Congenital Heart Disease in Infants

Nuclear angiocardiography with a gamma camera, a pinhole collimator, and 99mTc pertechnetate was performed on 43 children aged 3 years or less, including 10 neonates. Twenty-six children had congenital heart disease, which was confirmed at cardiac catheterization; the rest had no structural cardiac anomaly. Use of the pinhole collimator allowed magnification of cardiac images, with enhancement of resolution. Sensitivity was improved by positioning the pinhole 14 cm rather than 19 cm from the crystal of the gamma camera. Anterior and left lateral angiocardiograms were obtained with both 35-mm images at 0.3-sec intervals and cine-images at 18 frames/sec.Abnormalities in origin, size, and position of the great arteries, in chamber configurations, and in the time and course of activity in right and left heart, lungs, and great vessels were used to assist in identification of anomalies such as transposition of the great arteries, pulmonary atresia with intact ventricular septum, truncus arteriosus, and aortic atresia. 99mTc in a dose of 18.5 mCi/M2 of body area was used and produced whole-body and gonadal radiation doses less than 1 rad. The low risk and simplicity of the technic make it promising as a screening procedure and as an adjunct to cardiac catheterization for cyanosed infants.
Shades of brown and green: Party effects in proportional election systems

Small parties play an important role in proportional election systems. For example, the emergence and electoral success of environmental and anti-immigration parties have constituted one of the central changes in the political landscape in Europe over the last three decades. But we do not know if this has actually had any implications for policy, since no methods exist for credibly estimating the effect of legislative representation in proportional election systems. Because party representation is not randomly assigned, both observable and unobservable factors influence policy outcomes as well as party representation. Using a part of the legislative seat allocation that is as good as random, I estimate the causal effect of party representation on immigration policy, environmental policy and tax policy in Swedish municipalities. The results show that party representation has a large effect on the first two policies, but not on the tax policy.
An Approach towards Securing Data in Cloud Computing

Users store vast amounts of sensitive data on a cloud. Sharing sensitive data will help enterprises reduce the cost of providing users with personalized services and provide value-added data services. However, secure data sharing is problematic. Security is one of the most difficult task to implement in cloud computing. Different forms of attacks in the application side and in the hardware components. This paper proposes a framework for secure sensitive data sharing in cloud, including secure data delivery, storage, usage, and destruction on a semi-trusted in cloud environment. We present Kerberos protocol over the network and a user process protection method based on a virtual machine monitor, which provides support for the realization of system functions.
Exploratory analysis of point proximity in subspaces

We consider clustering as computation of a structure of proximity relationships within a data set in a feature space or its subspaces. We propose a data structure to represent such relationships, and show that, despite unavoidable arbitrariness in the clustering algorithms, constructive uses of their results can be made by studying correlations between multiple proximity structures computed from the same data. We describe a software tool that facilitates such explorations and example applications.
Dual feed planar inverted-F antenna for MIMO application

This paper presents a dual port planar inverted F antenna. This antenna consists of a radiating patch with two isolated feed which are perpendicular to each other to save the space and cost. Slot has been introduced in the ground plane to achieve the isolation between the two ports. The height of the antenna is taken as 3mm which makes it suitable for the handheld devices. From the simulated results it can be seen that antenna covers the frequency band from 2.1 to 2.9 GHz for S11 > −10db. This antenna can be used for wireless LAN, long term evolution (LTE) and for worldwide interoperability for Microwave Access (WiMAX) frequency ranging from 2.5 to 2.7 GHz. It can also be used in mobile handsets as diversity and multiple-input-multiple-output(MIMO) antenna for different applications.
[POSTER] Rubix: Dynamic Spatial Augmented Reality by Extraction of Plane Regions with a RGB-D Camera

Dynamic spatial augmented reality requires accurate real-time 3D pose information of the physical objects that are to be projected onto. Previous depth-based methods for tracking objects required strong features to enable recognition; making it difficult to estimate an accurate 6DOF pose for physical objects with a small set of recognizable features (such as a non-textured cube). We propose a more accurate method with fewer limitations for the pose estimation of a tangible object that has known planar faces and using depth data from an RGB-D camera only. In this paper, the physical object's shape is limited to cubes of different sizes. We apply this new tracking method to achieve dynamic projections onto these cubes. In our method, 3D points from an RGB-D camera are divided into a cluster of planar regions, and the point cloud inside each face of the object is fitted to an already-known geometric model of a cube. With the 6DOF pose of the physical object, SAR generated imagery is then projected correctly onto the physical object. The 6DOF tracking is designed to support tangible interactions with the physical object. We implemented example interactive applications with one or multiple cubes to show the capability of our method.
The integration of STS into science education

While classroom teachers will always be the key to achieving the educational goal expressed by Rubba above, teachers will be helped significantly by the availability of supportive classroom materials. The current paucity of STS science textbooks is, however, a serious hindrance to the successful integration of STS into science education (Bybee, 1991). Few science teachers have the time, energy, and resources to develop their own STS materials. As Bybee (1991) suggests, science teachers need an STS science textbook that translates STS theory into practical classroom practice. Most needed is an STS science textbook general enough to be relevant to all communities, but flexible enough to encourage teachers to integrate supplementary STS materials that deal with local or global issues of interest to their students.
Association of Klotho single nucleotide polymorphisms with cardiovascular diseases : a systematic review and meta-analysis

Objectives: A systematic review and meta-analysis was performed to confirm the relationship between the Klotho single nucleotide polymorphisms (SNPs) and the risk of cardiovascular disease (CVD). Methods: Electronic databases of PubMed, EMBASE, the Cochrane Library and China National Knowledge Infrastructure were searched. Case-control studies or observational studies were included. Data synthesis and analysis were performed using the statistical software STATA. Results: Sixteen studies including 9585 participants provided the valid data for exploring the correlation between the 4 Klotho SNPs and the risk of 3 kinds of CVDs. Overall results showed that the significant correlation was observed between the risk of CVDs and G-395A SNP under the additive genetic models (OR=1.23, 95% CI=1.08-1.40, P=0.001), dominant model (OR=1.24, 95% CI=1.05-1.45, P=0.009) and recessive model (OR=1.61, 95% CI=1.30-2.00, P<0.001). No significant associations were found between the risk of CVDs and C1818T, F352V and C370S SNPs (all P>0.05). Conclusion: This meta-analysis can indicate the G-395A, C1818T SNPs could be a risk factor for coronary heart disease, while the G-395A and F352V SNPs might be a risk for hypertension. No association between the risk of ischemic stroke and the G-395A, F352V and C1818T SNPs could be established from our meta-analysis.
From Light to Rich ERE: Annotation of Entities, Relations, and Events

We describe the evolution of the Entities, Relations and Events (ERE) annotation task, created to support research and technology development within the DARPA DEFT program. We begin by describing the specification for Light ERE annotation, including the motivation for the task within the context of DEFT. We discuss the transition from Light ERE to a more complex Rich ERE specification, enabling more comprehensive treatment of phenomena of interest to DEFT.
A Novel cis-Element That Is Responsive to Oxidative Stress Regulates Three Antioxidant Defense Genes in Rice1

All organisms have defense systems against oxidative stress that include multiple genes of antioxidant defense. These genes are induced by reactive oxygen species under condition of oxidative stress. In this study, we found that a 28-bp motif is conserved on the promoter regions of three antioxidant defense genes in rice (Oryza sativa): cytosolic superoxide dismutase (sodCc1), cytosolic thioredoxin (trxh), and glutaredoxin (grx). We demonstrated that the 28-bp sequence acts as a cis-element responsive to oxidative stress by transient expression assay and designated it as CORE (coordinate regulatory element for antioxidant defense). The CORE was activated by methyl viologen treatment and induced a 3.1-fold increase in expression of the reporter gene, but it did not respond to hydrogen peroxide. The expressions of the sodCc1, trxh, and grx genes were coordinately induced by methyl viologen, suggesting that multiple genes involved in antioxidant defense are controlled by a common regulatory mechanism via CORE. Application of the mitogen-activated protein kinase kinase inhibitor caused the constitutive induction of the sodCc1, trxh, and grx genes and the activation of CORE without methyl viologen treatment. These results indicate that a mitogen-activated protein kinase cascade is involved in the gene regulation mediated by CORE.
Territorial governance, networks and power: cross‐sectoral partnerships in rural poland

Abstract Research on the operation of territorial governance and rural development programmes is dominated by qualitative methodologies, paying little attention heretofore to the characteristics and structures of new horizontal and vertical relationship formations that are the explicit objective of the governance and rural development model. Seeking to address this deficit in the literature, this article adds to a small number of existing contributions that use social network analysis (SNA) to examine the role of inter‐organizational networks in shaping geographic functional regions in the context of governance. Rooted in the methodological perspective of SNA, the analysis focuses on relations between local actors participating in three area‐based rural partnerships in Poland, which are conceptualized as territorially embedded institutional network clusters. The structure of inter‐sectoral relations, understood as interactions (competition, conflict, coordination, cooperation, and control) and flows (information, financial, human, or tangible resources), between the institutional partners of these partnerships is examined. Analysing in detail attributes of network relations, the article identifies structural characteristics of the area‐based partnerships, such as manifestations of how diverse local resources are engaged and how dominance by traditional powerful stakeholders can be overcome by network structures. Structural dynamics and transformations that represent expressions and manifestations of how territorially embedded governance networks are expected to operate are important areas of inquiry in political geography. In this context, the particular empirical and theoretical capacity of SNA is illuminated in this article as part of a broader presentation of primary field data on how network governance and rural development is taking shape in Central and Eastern Europe.
Injecting security as aspectable NFR into Software Architecture

Complexity of the software development process is often increased by actuality of crosscutting concerns in software requirements; moreover, software security as a particular non-functional requirement of software systems is often addressed late in the software development process. Modeling and analyzing of these concerns and especially security in the software architecture facilitate detecting architectural vulnerabilities, decrease costs of the software maintenance, and reduce finding tangled and complex components in the ultimate design. Aspect oriented ADLs have emerged to overcome this problem; however, imposing radical changes to existing architectural modeling methods is not easily acceptable by architects. In this paper, we present a method to enhance conventional software architecture description languages through utilization of aspect features with special focuses on security. To achieve the goal, aspectable NFRs have been clarified; then, for their description in the software architecture, an extension to xADL 2.0 [E.M. Dashofy, 2005] has been proposed; finally, we illustrate this material along with a case study.
Time-based query performance predictors

Query performance prediction is aimed at predicting the retrieval effectiveness that a query will achieve with respect to a particular ranking model. In this paper, we study query performance prediction for a ranking model that explicitly incorporates the time dimension into ranking. Different time-based predictors are proposed as analogous to existing keyword-based predictors. In order to improve predicting performance, we combine different predictors using linear regression and neural networks. Extensive experiments are conducted using queries and relevance judgments obtained by crowdsourcing.
Spatial resources optimization in distributed MIMO networks with limited data sharing

Wireless access through a large distributed network of low-complexity infrastructure nodes empowered with cooperation and coordination capabilities, is an emerging radio architecture, candidate to deal with the mobile data capacity crunch. In the 3GPP evolutionary path, this is known as the Cloud-RAN paradigm for future radio. In such a complex network, distributed MIMO resources optimization is of paramount importance, in order to achieve capacity scaling. In this paper, we investigate efficient strategies towards optimizing the pairing of access nodes with users as well as linear precoding designs for providing fair QoS experience across the whole network, when data sharing is limited due to complexity and overhead constraints. We propose a method for obtaining a spatial resources allocation optimization solution which can be applied in networks of limited scale, as well as an approximation algorithm with bounded polynomial complexity which can be used in larger networks. The particular algorithm outperforms existing user-oriented clustering techniques and achieves quite high quality-of-service levels with reasonable complexity.
Analysis of the Thinopyrum elongatum Transcriptome under Water Deficit Stress

The transcriptome of Thinopyrum elongatum under water deficit stress was analyzed using RNA-Seq technology. The results showed that genes involved in processes of amplification of stress signaling, reductions in oxidative damage, creation of protectants, and roots development were expressed differently, which played an important role in the response to water deficit. The Th. elongatum transcriptome research highlights the activation of a large set of water deficit-related genes in this species and provides a valuable resource for future functional analysis of candidate genes in the water deficit stress response.
Evaluation of indicated suicide risk prevention approaches for potential high school dropouts.

OBJECTIVES This study evaluated the efficacy of 2 indicated preventive interventions, postintervention and at 9-month follow-up. METHODS Drawn from a pool of potential high school dropouts, 460 youths were identified as being at risk for suicide and participated in 1 of 3 conditions randomly assigned by school: (1) Counselors CARE (C-CARE) (n = 150), a brief one-to-one assessment and crisis intervention; (2) Coping and Support Training (CAST) (n = 155), a small-group skills-building and social support intervention delivered with C-CARE; and (3) usual-care control (n = 155). Survey instruments were administered pre-intervention, following C-CARE (4 weeks), following CAST (10 weeks), and at a 9-month follow-up. RESULTS Growth curve analyses showed significant rates of decline in attitude toward suicide and suicidal ideation associated with the experimental interventions. C-CARE and CAST, compared with usual care, also were effective in reducing depression and hopelessness. Among females, reductions in anxiety and anger were greater in response to the experimental programs. CAST was most effective in enhancing and sustaining personal control and problem-solving coping for males and females. CONCLUSIONS School-based, indicated prevention approaches are feasible and effective for reducing suicidal behaviors and related emotional distress and for enhancing protective factors.
Attitudes of primary initial teacher training students to special educational needs and inclusion

In this article Joseph Mintz explores the importance of developing positive attitudes to SEN and Inclusion among primary teacher trainees. The research reported indicates that student attitudes towards SEN/Inclusion were generally positive, but that such views are fluid and subject to change during a course of training. The article reinforces the importance of Initial Teacher Training in developing a workforce that is attuned to the individual pupils in schools.