Miracle-dz/UniFAR-FTUs huggingface dataset:
Drug‐induced hypersensitivity syndrome due to minocycline complicated by severe myocarditis

A 60‐year‐old woman presented with a 13‐day history of a generalized erythematous rash accompanied by fever, periorbital edema and axillary lymphadenopathy. Prior to the appearance of the rash, the patient had been treated with intermittent courses of oral minocycline for cystitis. The patient was diagnosed with drug‐induced hypersensitivity syndrome (DIHS) due to minocycline. During the admission, infectious endocarditis was suspected and the patient was treated with i.v. gammaglobulin (0.4 g/kg per day). The following day, the patient suffered from systemic deterioration and symptomatic low blood pressure that prompted repeat echocardiography which revealed an ejection fraction of 10%. DIHS‐associated myocarditis was suspected and management with circulation assistance devices and steroid pulse therapy were started, resulting in satisfactory resolution. A rise in titer of human herpesvirus‐6, cytomegalovirus and Herpes simplex virus‐1 antibodies was detected. Although minocycline‐induced myocarditis is rare, this severe drug reaction should be considered with DIHS.
Borderline personality disorder subtypes: A factor analysis of the DSM‐IV criteria

This study examined the underlying factor structure of the DSM-IV criteria to determine whether the diagnosis could be classified into subtypes. It also sought to enhance the clinical interpretation of any identified subtypes by examining their relation to comorbid axis I and II disorders. In 95 treatment-seeking adults (82 women, 13 men), attending a psychiatric outpatient clinic principle components analysis yielded support for three subtypes: ‘affect dysregulation’, ‘rejection sensitivity’ and ‘mentalization failure’. Results of logistic regression analyses indicated that the affect dysregulation subtype was associated with the comorbid diagnosis of generalized anxiety and panic disorder and other cluster B and C personality disorders. The mentalization failure subtype was found to be predictive of posttraumatic stress disorder and other cluster B personality disorders. With further research, confirmation of these subtypes may inform diagnostic revisions and appropriate treatment regimes that are individually designed to target the patients' core symptoms. Copyright © 2012 John Wiley & Sons, Ltd.
Multi-Language Neural Network Language Models

Copyright © 2016 ISCA. In recent years there has been considerable interest in neural network based language models. These models typically consist of vocabulary dependent input and output layers and one, or more, hidden layers. A standard problem with these networks is that large quantities of training data are needed to robustly estimate the model parameters. This poses a challenge when only limited data is available for the target language. One way to address this issue is to make use of overlapping vocabularies between related languages. However this is only applicable to a small set of languages, and the impact is expected to be limited for more general applications. This paper describes a general solution that allows data from any language to be used. Here, only the input and output layers are vocabulary dependent whilst hidden layers are shared, language independent. This multi-task training set-up allows the quantity of data available to train the hidden layers to be increased. This multi-language network can be used in a range of configurations, including as initialisation for previously unseen languages. As a proof of concept this paper examines multilingual recurrent neural network language models. Experiments are conducted using language packs released within the IARPA Babel program.
Molecular analysis of mutations affecting hprt mRNA splicing in human T‐lymphocytes in vivo

Molecular analysis of hypoxanthine‐guanine phosphoribosyltransferase (hprt) cDNA from 6‐thioguanine‐resistant T‐lymphocytes cloned from smoking and non‐smoking adult donors showed that 35% of these mutants were defective in splicing of hprt mRNA. Among a set of 42 hprt splice mutants, we observed i) complete loss of one or more exons, ii) partial loss of one exon, or iii) inclusion of part of an intron sequence between adjacent exons. Loss of exon 4 was significantly more frequent than of the other exons, suggesting that the sequences that regulate splicing of this exon are either larger than those of the other exons or especially prone to mutation. In order to identify the molecular nature of DNA alterations causing aberrant splicing of hprt mRNA, 17 splice mutants were analyzed in more detail by sequencing the genomic regions flanking the mis‐spliced exon. Base pair substitutions or small deletions causing defective splicing were either detected in exon sequences or in splice site consensus sequences of introns. Furthermore, genomic deletions encompassing entire exons were found. In some mutants, the alteration responsible for incorrect splicing could not be identified, suggesting that the target sequence for splice mutations is larger than merely the splice junctions. Molecular characterization of hprt splice mutations will lead to the identification of specific sequences regulating splicing of hprt mRNA and will reveal whether the mutational spectrum in splice mutants is similar to that found in the hprt coding region.
An Empirical Study of the Evolution of an Agile-Developed Software System

We have analyzed evolution patterns over two and a half years for a system developed using extreme programming. We find that the system shows a smooth pattern of growth overall, that (McCabe) code complexity is low, and that the relative amount of complexity control work (e.g. refactoring) is higher than in other systems we have studied. To interpret these results, we have drawn on qualitative data including the results of an observational study, records of progress and productivity, and comments on our findings from team members.
Structural study on the architecture of the bacterial ATP synthase Fo motor

We purified the Fo complex from the Ilyobacter tartaricus Na+-translocating F1Fo-ATP synthase and performed a biochemical and structural study. Laser-induced liquid bead ion desorption MS analysis demonstrates that all three subunits of the isolated Fo complex were present and in native stoichiometry (ab2c11). Cryoelectron microscopy of 2D crystals yielded a projection map at a resolution of 7.0 Å showing electron densities from the c11 rotor ring and up to seven adjacent helices. A bundle of four helices belongs to the stator a-subunit and is in contact with c11. A fifth helix adjacent to the four-helix bundle interacts very closely with a c-subunit helix, which slightly shifts its position toward the ring center. Atomic force microscopy confirms the presence of the Fo stator, and a height profile reveals that it protrudes less from the membrane than c11. The data limit the dimensions of the subunit a/c-ring interface: Three helices from the stator region are in contact with three c11 helices. The location and distances of the stator helices impose spatial restrictions on the bacterial Fo complex.
Are you what you eat? Experimental evidence on risk preferences and health habits

We run an experiment to assess whether preferences for risk significantly differ for individuals with different health habits and not extreme health conditions. We administrate a questionnaire followed by an experimental test to a sample of 120 young subjects in the UK population. The questionnaire measures health characteristics and life style, and assesses details about individual nutritional balance, drinking, smoking and physical exercise. We construct a number of individual health and nutritional indexes, including the Healthy Eating Index (HEI) based on the USDA guidelines. We use HEI as a measure to complement the Body Mass Index (BMI), that has been criticised from many parts as a poor indicator of the overall nutritional and health quality of diet, especially for subjects with not extreme health conditions. We elicit preferences for risk using variants of the Holt and Laury (2002a) paired lotteries incentive-compatible test. Using Maximum Likelihood methods, we estimate risk preferences for the subjects in our sample, allowing risk aversion to vary with individual health and life style variables. We observe that risk preferences significantly differ between young male and female subjects with different health habits. In particular, male smokers do not appear to be characterized by significantly different preferences towards risk when compared to male non smokers. Moreover, while there is no significant association for females, male subjects with higher BMI tend to be more risk-seeking. The association of BMI with risk preferences, however, disappears when the analysis directly controls for the quality of individual diet with the inclusion of the HEI, or of other related sub-indexes: subjects with better nutritional habits tend to be more risk averse. We also find association between drinking habits and risk preferences for young female subjects. We relate our experimental evidence to the discussion of how to inform the design of health policies targeting risky behaviour in the early phases of adult life, when prevention campaigns are more likely to succeed.
Honors and awards

One of SEG's great traditions is the special recognition of individuals and organizations for their contributions to geophysics and to the Society. The following individuals and groups were honored during a ceremony at the 2019 SEG Annual Meeting in San Antonio, Texas. Their names, as well as the names of past awardees, are listed at https://seg.org/about-seg/governance/honors-and-awards .
“Unidirectional” Atrioventricular Conduction Studied by Microelectrodes

By applying microelectrode technic in isolated dog hearts, the nature of the so-called unidirectional conduction of the atrioventricular conduction was investigated. Retrograde conduction, i.e., conduction from the ventricle, occurred frequently in the isolated whole heart from which the sinus node was removed, or in a preparation composed of the interatrial septum, right atrium, right ventricle, interventricular septum, and atrioventricular conduction system. Retrograde conduction was blocked just as frequently. In such cases, this unidirectional block was found not to be ascribed solely to the refractory period of the atrioventricular node or of the atrial muscle fibers. The site of unidirectional block was found to be located in the domain of the ventricle, i.e., in the region adjacent to the postero-inferior margin of the membranous portion of the interventricular septum. This site is of a very limited extension. This point responded to ventricular stimuli, frequently by localized depolarization only, or in the manner of decremental conduction, whereas following atrial stimuli, it responded with full-sized action potential. By histologic examination, it was found that this point is situated in the ventricular portion of the bundle of His, just above the bifurcating point to the right and left branches.
The cartoon guide to genetics

Have you ever asked yourself: Are spliced genes the same as mended Levis? Watson and Crick? Aren't they a team of British detectives? Plant sex? Can they do that? Is Genetic Mutation the name of one of those heavy metal bands? Asparagine? Which of the four food groups is that in? Then you need The Cartoon Guide to Genetics to explain the important concepts of classical and modern genetics-it's not only educational, it's funny too!
Concurrent vowel identification. I. Effects of relative amplitude and F0 difference

Subjects identified concurrent synthetic vowel pairs that differed in relative amplitude and fundamental frequency (F0). Subjects were allowed to report one or two vowels for each stimulus, rather than forced to report two vowels as was the case in previously reported experiments of the same type. At all relative amplitudes, identification was better at a fundamental frequency difference (ΔF0) of 6% than at 0%, but the effect was larger when the target vowel amplitude was below that of the competing vowel (−10 or −20 dB). The existence of a ΔF0 effect when the target is weak relative to the competing vowel is interpreted as evidence that segregation occurs according to a mechanism of cancellation based on the harmonic structure of the competing vowel. Enhancement of the target based on its own harmonic structure is unlikely, given the difficulty of estimating the fundamental frequency of a weak target. Details of the pattern of identification as a function of amplitude and vowel pair were found to be inco.
Diagnosing resistive bridges using adaptive techniques

A systematic procedure for locating resistive bridges is presented. Critical path tracing is used to identify a set of "suspect" bridges whose presence could explain all of the observed faulty behavior of the circuit for the original test set. The set of suspects is then reduced by adaptively applying additional tests derived from the failing vector pairs in the original test set. Unlike other approaches, the approach presented here is not based on any bridge fault modeling and does not require any fault simulation.
Ecologic studies of Japanese encephalitis virus in Japan. VI. Swine infection.

Summary At the Shinhama heronry and nearby Minamigyotoku village near Tokyo, Japan, in 1953, C. tritaeniorhynchus, the major vector of Japanese encephalitis virus in Japan, entered traps baited with Black-crowned Night Herons in numbers 3 to 15 times greater than traps containing egrets or chickens; Blue Magpies, Tree Sparrows, Dusky Thrushes, and Grey Starlings failed to attract significant numbers. In 1956, at two rural and one urban location near Tokyo, pigs attracted and were bitten by many more C. tritaeniorhynchus than BCNH or man. C. tritaeniorhynchus were found in traps as high as 50 feet above ground at the Sagiyama heronry. The behavior of the vector mosquito explained in part the different incidences of virus infection among bird species, the high incidence of swine infection in nature, and infection of nestling birds high in trees at Sagiyama. Whatever animal mechanism exists for attracting C. tritaeniorhynchus, it persisted in traps for 1 to 3 days after removal of the animal. Other mosquitoes behaved differently from C. tritaeniorhynchus. C. pipiens frequently entered traps with all seven species of birds and was attracted to BCNH in traps more than to pigs. A. sinensis was found in significant numbers only in pig-baited traps in rural areas. Other species were recovered only in small numbers. Microhabitats affected entry of mosquitoes into traps and necessitated study of multiple trap sites with duplicate traps. On one occasion C. tritaeniorhynchus collections were influenced by factors related to the individual trap per se and independent of trap design or location. These studies emphasized that predictions of virus ecology from knowledge of mosquito behavior alone may be erroneous.
Software multiplication using Gaussian normal bases

Fast algorithms for multiplication in finite fields are required for several cryptographic applications, in particular for implementing elliptic curve operations over binary fields F2m. In this paper, we present new software algorithms for efficient multiplication over F2m that use a Gaussian normal basis representation. Two approaches are presented, direct normal basis multiplication and a method that exploits a mapping to a ring where fast polynomial-based techniques can be employed. Our analysis, including experimental results on an Intel Pentium family processor, shows that the new algorithms are faster and can use memory more efficiently than previous methods. Despite significant improvements, we conclude that the penalty in multiplication is still sufficiently large to discourage the use of normal bases in software implementations of elliptic curve systems
Chronological Change of Resistance to β-Lactams in Salmonella enterica serovar Infantis Isolated from Broilers in Japan

Epidemiologic surveillance study was conducted in southern Japan to determine the antimicrobial resistance phenotypes and characterize the β-lactamase genes and the plasmids harboring these genes in Salmonella enterica serovar Infantis (S. Infantis) isolates from broilers. Between January, 2007 and December, 2008, a total of 1,472 fecal samples were collected and examined at the Laboratory of Veterinary Public Health, Kagoshima University, Japan. In 93 (6.3%) isolates recovered, 33 (35.5%) isolates showed resistance to cefotaxime, an extended-spectrum cephalosporin (ESC), conferred by TEM-20, TEM-52 and CTX-M-25 extended-spectrum β-lactamases (ESBLs). In addition to ESC-resistance, eight (8.6%) isolates exhibited resistance to cefoxitin mediated by CMY-2 AmpC β-lactamase. Plasmid analysis and polymerase chain reaction replicon typing revealed the blaTEM-20 and blaCMY-2 genes were associated with IncP plasmids, blaTEM-52 was linked with a non-typable plasmid and blaCTX-M-25 was carried by an IncA/C plasmid. Non-β-lactam resistance to streptomycin, sulfamethoxazole, and oxytetracycline encoded by the aadA1, sul1, and tet(A) genes, respectively, was found in 86 (92.5%) isolates. Resistance to kanamycin and ofloxacin was exhibited in 12 (12.9%) and 11 (11.8%) isolates, respectively, the former was mediated by aphA1-Iab. These data indicate that S. Infantis isolates producing ESBLs and AmpC β-lactamase have spread among broiler farms in Japan. These data demonstrated that the incidence of ESC-resistant S. Infantis carrying blaTEM-52 remarkably increased and S. Infantis strains harboring blaCMY-2, blaTEM-20, or blaCTX-M-25 genes emerged from broilers in Japan for the first time in 2007 and 2008.
University Graduates’ Skills Mismatches in Central Asia: Employers’ Perspectives From Post-Soviet Tajikistan

This paper examines employers’ perspectives about university graduates’ skills and preparation for employment in post-Soviet Tajikistan. It explores the mismatch between the skills university graduates acquire and the skills required in the job market, and addresses some of the underlying reasons for the perceived skills mismatch. Thematic analysis of interviews with employers’ and secondary data suggest that the quality of higher education has declined considerably over the past two decades, widening the gap between the skills acquired by university graduates and those required by employers. The findings show that despite a rapid expansion of the higher education sector in Tajikistan, an increasing number of individuals are obtaining degrees, but fail to demonstrate a basic understanding of their field of study. I argue that while the skills mismatch derives from the challenges faced by the education system, a latent labor market and a weak economy are also contributing to the skills mismatch. The goals set by politicians and policy-makers, envisioning the internationalization of education and the preparation of the graduates to be responsive to the local and global labor market needs, seem far from being achieved in the near future. Employers’ perspectives suggest that the reform of the education sector without the creation of more decent job opportunities will likely exacerbate the current skills mismatch in Tajikistan.
Beyond stability: Predicting inter‐individual differences in intra‐individual change

Demonstration of a high longitudinal stability of inter‐individual diferences in behaviour has been one traditional goal of personality psychology. In recent years, impressively high longitudinal correlations have been reported for self‐and other‐ratings of behaviour in adulthood, indicating a high overall stability of personality differences in that period of development. However, even 5‐year correlations around 0.70 do not exclude major deviations of some of the subjects from this overall stability (i.e. differential stability in the sample). Furthermore, the younger a sample is, the lower will be the longitudinal stability observed, and the less suficient is the explanation of inter‐individual diferences by static traits. This article goes beyond the notion of stability at the sample level by asking from a developmental perspective (a) whether systematic inter‐individual differences in intra‐individual change exist, (b) how they can be assessed, and (c) whether these inter‐individual differences can be explained by characteristics of the person or of the environment.
EEX base and peak load one-year forward contracts: Stochastic volatility

The paper applies a Bayesian Estimator adapting MCMC simulation methodologies to build a general scientific stochastic volatility (SV) model for the mean and latent volatility of the base and peak load EEX one-year forward electric power contracts. The main objective is to find appropriate descriptions emphasizing schemes for portfolio management, risk management and general derivative pricing purposes. Moreover, as forecasting under the MCMC framework can be done easily for both the mean and volatility, the model building approach can produce useful and superior volatility and correlation updating schemes. The stochastic volatility model is — on a parameterized statistical model for simulation purposes and the estimation uses the MCMC simulation techniques. The methodology helps to circumvent the computational curse of dimensionality and is therefore superior to conventional derivative-based hill climbing optimizers. Our results show that the general scientific methodology from the Bayesian model parameter estimation, adequately describes the European energy market's financial contracts. The successful implementation to energy markets suggests not whether the methods can be used in financial market applications, but how efficient the methods can generally become.
Weak invariant simulation: Properties and algorithms

Large-scale networks consisting of similar similar subprocesses can conveniently be modeled as Parameterized Discrete Event Systems (PDES). This modeling is particularly useful when the number of subprocesses is arbitrary, unknown or time-varying. Unfortunately, key problems such as checking the nonblocking property in these networks are undecidable. Moreover, mathematical tools supporting analysis of these networks are very limited. In previous work, we introduced weak invariant simulation in its preliminary form as a new mathematical notion for analysis of deterministic PDES and for defining tractable subclasses of PDES. In this paper, we broaden the definition of weak invariant simulation for nondeterministic PDES and give more insight into its properties. We compare weak invariant simulation to other simulation relations in the literature. Moreover, we propose a method to check whether a process weakly invariantly simulates another process with respect to a specific subalphabet. The greatest lower bound of all weak invariant simulations between two processes is also introduced. To illustrate the significance of weak invariant simulation, we outline its application to deadlock analysis of parameterized networks.