Miracle-dz/UniFAR-FTUs huggingface dataset:
The text-image-link-editor: A tool for linking facsimiles and transcriptions, and image annotations

TextGrid’s Text-Image-Link-Editor is used to link segments of text with sections on the corresponding image. A typical application is the linking of scans of facsimiles with their transcriptions, though these texts can also be created during the linking process, which allows also for image annotations. The information on the linking between manuscript fragments and the corresponding transcription is itself stored in TEI P5. TextGrid is a virtual research environment for the humanities disciplines dealing with texts in a wide sense (philologies, epigraphy, linguistics, musicology, art history, etc.). The joint research project TextGrid is part of the D-Grid initiative and is funded by the German Federal Ministry of Education and Research (BMBF) for the period starting from 1 June 2009 to 31 May 2012 (reference number: 01UG0901A). TextGrid consists of two principal building blocks, the grid-based back-end TextGridRep that hosts both infrastructure services and the repository layer for access to research data and long-term archiving, and the user-facing TextGrid Laboratory (TextGridLab). The TextGridLab, a single point of entry to the virtual research environment, provides integrated access to both new and existing tools and services via user-friendly software based on the eclipse framework [TG]. TBLE is a key component of the TextGridLab that has been under continuous development since 2008 and is by now in practical use.
Continuous Glucose Monitoring System in a Rural Intensive Care Unit: A Pilot Study Evaluating Accuracy and Acceptance

Background: Glucose management in an intensive care unit (ICU) is labor-intensive. A continuous glucose monitoring system (CGMS) has the potential to improve efficiency and safety in this setting. The goal of this study was to determine if the Medtronic Guardian® REAL-Time CGMS was accurate and tolerated by patients in a rural hospital ICU unit. Method: Differences between individual finger stick blood glucose (FSBG) and CGMS values were compared to American Diabetes Association (ADA) and International Organization for Standardization (ISO) standards. Continuous glucose monitoring system accuracy was evaluated over four ranges: <75, 75–140, 140–200, and >200 mg/dl. Other accuracy measures [mean absolute deviation (MAD), mean absolute relative difference (MARD), and coefficient of linear regression of CGMS on FSBG] were calculated. Nursing staff and patients were surveyed regarding use of the CGMS in the ICU. Results: Twenty-nine participants had 320 FSBG and corresponding CGMS readings. Sixty-two percent of participants were admitted with diabetic ketoacidosis (DKA). Two hundred and thirteen (66.6%) were accurate within the ISO standard, whereas only 70 out of 320 (21.9%) were within the 5% ADA standard. The CGMS was most accurate in euglycemia. Technical difficulties, such as adequate time for “wetting” and calibration of electrodes, arose with the sensors. The MAD was 28.3 mg/dl, the MRAD was 17.4%, and the linear regression coefficient of CGMS on FSBG was 0.834 (p < 0.001). Conclusions: The CGMS is well tolerated by ICU patients but, at present, is not sufficiently accurate to be used for therapeutic decisions in the acute setting, particularly in patients with diabetic ketoacidosis. There is a need to find resolution to the technical issues regarding electrode “wetting” and calibration if CGMS use in the ICU setting is to provide an effective means of diabetes care and management.
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for First Relapse of Ovarian Cancer.

BACKGROUND To assess impact of surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients treated for a first relapse of ovarian cancer (FROC). PATIENTS AND METHODS Patients with a FROC treated with second-line chemotherapy, surgery and HIPEC were retrospectively included from 13 Institutions. Studied parameters were interval free between the end of initial treatment and the first relapse, second-line chemotherapy, peritoneal cancer index and completeness of surgery, HIPEC, mortality and morbidity, pathological results and survival. RESULTS From 2001 to 2010, 314 patients were included. The main strategy was secondary chemotherapy followed by surgery and HIPEC (269/314-85.6%). Mortality and morbidity rates were respectively 1% and 30.9%. Median follow-up was 50 months, 5-year overall survival was 38.0%, with no difference between platinum-sensitive or -resistant patients and 5-year disease-free survival was 14%. CONCLUSION HIPEC allows encouraging survival in the treatment of FROC, better in case of complete surgery, with acceptable mortality and morbidity rates.
Effects of Oxidative Stress and Antenatal Corticosteroids on the Pulmonary Expression of Vascular Endothelial Growth Factor (VEGF) and Alveolarization

The lung is the human organ most susceptible to oxidative damage. The transition from fetal, a low-oxygen environment, to FiO2: 0.21, induces a relative degree of oxidative stress for all newborns, but especially in the case of preterm neonates whose lung development has been interrupted. A supplementary supply of oxygen (hyperoxia) is often used to treat preterm newborns and these infants may not yet be prepared to protect their lungs from oxidative injury.
Age of diagnosis of colorectal cancer in HNPCC patients is more complex than that predicted by R72P polymorphism in TP53

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominantly inherited cancer syndrome associated with germline mutations in DNA mismatch repair (MMR) genes. Recently a polymorphism at codon 72 (R72P) in the tumour suppressor gene TP53 has been implicated in the age of disease onset in HNPCC. In this report we have studied a large cohort of HNPCC patients to assess the impact of this polymorphism on disease expression and age of diagnosis of colorectal cancer (CRC). DNA samples from 218 HNPCC mutation positive patients from Australia and Poland were genotyped for the arginine to proline change at codon 72 in the TP53 gene. The association between the polymorphism and disease characteristics (mutation status, disease expression and age of diagnosis of CRC) was tested using Pearson's Chi‐square and Kaplan–Meier survival analysis. Our study of Australian and Polish HNPCC patients does not provide evidence for an association between the Arg/Pro (GC) genotype of the R72P polymorphism and age of diagnosis of CRC. The R72P polymorphism was examined in HNPCC patients and found to be not associated with disease development in either the Australian or Polish populations. When gene mutation status (hMLH1 or hMSH2) was included in the analysis some evidence of an affect was observed. The genotyping revealed in the Australian population that the R72P polymorphism was under‐represented in the hMSH2 group whereas it was over‐represented in the Polish hMSH2 group. A similar trend was observed for hMLH1 in both groups but was not significant. Age of diagnosis of CRC in HNPCC patients is therefore more complex than that predicted by the R72P TP53 polymorphism alone, suggesting an inter‐relationship with other genetic and/or environmental factors. © 2005 Wiley‐Liss, Inc.
Complement fixation reaction and agar gel double diffusion test in Tyzzer's disease of mice.

Complement fixation reaction and agar gel double diffusion test were made using as antigens, water or phosphate buffer saline extracts of liver from mice severely infected with Tyzzer's disease. The supernatant of the extract heated at 56 C for 30 minutes was highly reactive with immune mouse serum in the complement fixation test, while an intense precipitate band was observed only with unhealed extracts in agar gel double diffusion tests. Cross reactions were observed in both tests between liver extracts from mice infected with different strains of organisms originating from different sources and showing varied degrees of virulence. Such reactions were not shown between Tyzzerimmune serum and liver extracts from uninfected or murine hepatitis-infected mice, nor were they shown between the Tyzzer-antigen and normal or anti-murine hepatitis virus serum. The complement fixation test was used to test retired breeder mouse sera for disease contamination in mouse colonies. Positive reactions were observed in test sera collected from some breeding colonies that subsequently proved to be contaminated by the cortisone provocation test in young animals.
Two-Photon Intravital Imaging of Lungs during Anthrax Infection Reveals Long-Lasting Macrophage-Dendritic Cell Contacts

ABSTRACT The dynamics of the lung immune system at the microscopic level are largely unknown because of inefficient methods of restraining chest motion during image acquisition. In this study, we developed an improved intravital method for two-photon lung imaging uniquely based on a posteriori parenchymal tissue motion correction. We took advantage of the alveolar collagen pattern given by the second harmonic generation signal as a reference for frame registration. We describe here for the first time a detailed dynamic account of two major lung immune cell populations, alveolar macrophages and CD11b-positive dendritic cells, during homeostasis and infection by spores of Bacillus anthracis, the agent of anthrax. We show that after alveolar macrophages capture spores, CD11b-positive dendritic cells come in prolonged contact with infected macrophages. Dendritic cells are known to carry spores to the draining lymph nodes and elicit the immune response in pulmonary anthrax. The intimate and long-lasting contacts between these two lines of defense may therefore coordinate immune responses in the lung through an immunological synapse-like process.
Fintech Waqaf: Solusi Permodalan Perusahaan Startup Wirausaha Muda

Money waqaf in Indonesia has a huge potential. Despite the fact, this huge potential has not been organized and utilized optimally by the waqaf management agency. Another problem faced in waqaf money is the difficulties in integrate the system of funding, financing, mauquf alaih, and distribute the beneficiaries. In the present era, waqaf in Indonesia has not been digitalized and has not used the Financial Technology (FinTech) system, so it is less economically and inefficient. The expected benefits of the research are waqaf can be a solution to the capital problems that have been faced by start-up companies which mostly un-bankable. In other side, it hopefully can encourage Nadzir to be involved in growing and developing entrepreneurship for youth starting with establishing a start-up company. This research approach is qualitative descriptive. The data is primary data with data collection techniques namely focus group discussions and interviews. The objects of the research are 30 youth start-ups in Surabaya. The result of study is that money waqf can be an alternative solution of capital problems for youth start-up companies who are un-bankable. The Sharia Financial Technology (SFT) system is a system that capable of integrating nadzir with Islamic Financial Institutions Accep Cash Waqf (IFIACW), funding, financing, mauquf alaih, start-up investors, Islamic Financing Guarantee Institution (IFGI) and Islamic Banks.
Sequence and analysis of a 26·9 kb fragment from chromosome XV of the yeast Saccharomyces cerevisiae

We have determined the nucleotide sequence of a fragment of chromosome XV of Saccharomyces cerevisiae cloned into cosmid pEOA048. The analysis of the 26 857 bp sequence reveals the presence of 19 open reading frames (ORFs), and of one RNA‐coding gene (SNR17A). Six ORFs correspond to previously known genes (MKK1/SSP32, YGE1/GRPE/MGE1, KIN4/KIN31/KIN3, RPL37B, DFR1 and HES1, respectively), all others were discovered in this work.
Novel GLRA1 Missense Mutation (P250T) in Dominant Hyperekplexia Defines an Intracellular Determinant of Glycine Receptor Channel Gating

Missense mutations as well as a null allele of the human glycine receptor α1 subunit gene GLRA1 result in the neurological disorder hyperekplexia [startle disease, stiff baby syndrome, Mendelian Inheritance in Man (MIM) #149400]. In a pedigree showing dominant transmission of hyperekplexia, we identified a novel point mutation C1128A of GLRA1. This mutation encodes an amino acid substitution (P250T) in the cytoplasmic loop linking transmembrane regions M1 and M2 of the mature α1 polypeptide. After recombinant expression, homomeric α1P250T subunit channels showed a strong reduction of maximum whole-cell chloride currents and an altered desensitization, consistent with a prolonged recovery from desensitization. Apparent glycine binding was less affected, yielding an approximately fivefold increase inKi values. Topological analysis predicts that the substitution of proline 250 leads to the loss of an angular polypeptide structure, thereby destabilizing open channel conformations. Thus, the novel GLRA1 mutant allele P250T defines an intracellular determinant of glycine receptor channel gating.
Measurement-Based Investigation of 60 GHz Broadband Transmission for Wireless In-Car Communication

In this paper we investigate the 60 GHz in-car wide- band radio channel to assess the feasibility of 60 GHz high bit rate radio communication inside a car. The investigations are based on a measurement campaign comprising different application- oriented transmission scenarios and propagation conditions. We analyze the channel gain, time dispersion and frequency selec- tivity. Finally, we derive the achievable signal-to-noise ratio and cover interference aspects. I. INTRODUCTION Today, premium class cars are equipped with a multitude of electronic entertainment and infotainment devices like DVD players, in-car-TV, navigation systems, cameras etc. Those devices are typically connected to each other via the automo- tive cable harness consisting of wires for various bus systems and point-to-point links. The cable harness in current vehicles has a significant weight that may exceed 30 kg. In particular, when utilizing higher bit rates for the data communication, this figure would even grow further due to necessary cable shielding and bulkier connectors. It becomes evident that a reduction of CO2 emissions in cars can also be achieved by utilizing alternative ways of data communication within the vehicle. Future broadband 60 GHz systems are supposed to operate in the unlicensed band from 57 to 64 GHz and are a can- didate for wireless indoor (1) and in-cabin (2) high speed internet access as well as real-time video streaming. It is well known that the channel characteristics strongly depend on the propagation environment (3). Results in the literature mostly refer to 60 GHz indoor channels (4). Very few results are available for more specific scenarios like aircraft cabins (2). To the authors' knowledge the millimeter wave in-car channel has not been considered yet. In this paper we thoroughly investigate the 60 GHz in-car wideband radio channel on the basis of measurement results for a Sport Utility Vehicle (SUV) to assess the feasibility of 60 GHz high bit rate radio communication inside a car.
[Follow-up study on patients with vernal keratoconjunctivitis undergoing topical 0.1% tacrolimus treatment].

PURPOSE A retrospective study for evaluating the clinical course of patients with vernal keratoconjunctivitis (VKC) treated with topical tacrolimus ophthalmic suspension 0.1% (Tacrolimus). SUBJECTS AND METHODS Subjects were 30 patients (24 men and 6 women) with VKC who were treated with a combined therapy of Tacrolimus and antiallergic ophthalmic solution, and could be followed up for six months. The subjects were divided into two groups: 1. A conversion treatment group in which Tacrolimus was substituted for a steroid ophthalmic solution [21 patients; average age 14.7 +/- 9.44 years (mean +/- SD)] and 2. An additional treatment group receiving Tacrolimus and anti-allergic ophthalmic solution [9 patients; average age 28.2 +/- 7.31 years (mean +/- SD)]. The therapeutic effects of the patients were evaluated chronologically using the ocular clinical score according to the papillae-limbus-cornea grading score and eosinophil cationic protein (ECP) levels in tears. RESULTS Papillae-limbus-cornea grading scores were significantly decreased from 8 (median) points at instillation initiation to 5 points at the first month after initiation of Tacrolimus treatment (p < 0.01, Steel test). Tear ECP levels were significantly decreased from 3493.6 (median) ng/ml at instillation initiation to 205.6 ng/ml at the first month after initiation of Tacrolimus treatment (p < 0.05, Steel test). During the course, four cases of exacerbation were found among the 30 cases, but no infections of the anterior segment were found. CONCLUSION The therapeutic effect of Tacrolimus eye drops for vernal keratoconjunctivitis was remarkable at one month after instillation initiation. For evaluating the effect of treatment and diagnosing exacerbation in VKC treated with Tacrolimus, a follow-up examination using clinical indexes such as the papillae-limbus-cornea grading score and ECP levels in tears is beneficial.
Boosting for Multiclass Semi-Supervised Learning

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Computational characterization of proteins

Computational characterization of proteins is a necessary first step in understanding the biologic role of a protein. The composite architecture of mammalian proteins makes the prediction of the biologic role rather difficult. Nevertheless, integration of many different prediction methods allows for a more accurate representation. Information on the 3D structure of a protein improves the reliability of predictions of many features. This article reviews existing methods used to characterize proteins and several tools that provide an integrated access to different types of information. The authors point out the increasing importance of structural constraints and an increasing need to integrate different approaches.
Trk Activation of the ERK1/2 Kinase Pathway Stimulates Intermediate Chain Phosphorylation and Recruits Cytoplasmic Dynein to Signaling Endosomes for Retrograde Axonal Transport

The retrograde transport of Trk-containing endosomes from the axon to the cell body by cytoplasmic dynein is necessary for axonal and neuronal survival. We investigated the recruitment of dynein to signaling endosomes in rat embryonic neurons and PC12 cells. We identified a novel phosphoserine on the dynein intermediate chains (ICs), and we observed a time-dependent neurotrophin-stimulated increase in intermediate chain phosphorylation on this site in both cell types. Pharmacological studies, overexpression of constitutively active MAP kinase kinase, and an in vitro assay with recombinant proteins demonstrated that the intermediate chains are phosphorylated by the MAP kinase ERK1/2, extracellular signal-regulated kinase, a major downstream effector of Trk. Live cell imaging with fluorescently tagged IC mutants demonstrated that the dephosphomimic mutants had significantly reduced colocalization with Trk and Rab7, but not a mitochondrial marker. The phosphorylated intermediate chains were enriched on immunoaffinity-purified Trk-containing organelles. Inhibition of ERK reduced the amount of phospho-IC and the total amount of dynein that copurified with the signaling endosomes. In addition, inhibition of ERK1/2 reduced the motility of Rab7- and TrkB-containing endosomes and the extent of their colocalization with dynein in axons. NGF-dependent survival of sympathetic neurons was significantly reduced by the overexpression of the dephosphomimic mutant IC-1B-S80A, but not WT IC-1B, further demonstrating the functional significance of phosphorylation on this site. These results demonstrate that neurotrophin binding to Trk initiates the recruitment of cytoplasmic dynein to signaling endosomes through ERK1/2 phosphorylation of intermediate chains for their subsequent retrograde transport in axons.
Minimal filtered channel features for pedestrian detection

This paper addresses the problem of efficient pedestrian detection using features that are extracted by convolving feature channels with a very small number of filters. The method uses as feature channels low level features such as LUV colour and HOG, and trains a boosted decision forest on top of the learned features. The feature selection is guided by a greedy search or by an exhaustive search on a few number of scaled versions of simple horizontal, vertical and uniform filters. Extensive results on the challenging Caltech dataset show that with only 3 filters we obtain state-of-the-art results achieving a 18.3% miss rate (MR). Using optical flow as an additional input, we further improve the results and obtain a 15.5% MR.
Evaluation of the effects of cocaine, heroin and naltrexone, alone and in combination, on milk drinking in rats

The effects of cocaine, alone and in combination with either heroin or naltrexone, were examined using a milk drinking procedure in rats. Rats (n = 8) were given access to a sweetened milk solution for 15 min daily until intake had stabilized (3 days with less than 10% variation across days). Rats were first administered saline or one of five doses of either cocaine (2.0–32 mg/kg, i.p.) or heroin (0.4–3.2 mg/kg, i.p.) 15 min prior to milk access. The dose-response function for cocaine was then determined in combination with either 0.8 mg/kg or 1.6 mg/kg heroin. Both cocaine and heroin administered alone produced dose-dependent decreases in milk drinking. Combination with 0.8 mg/kg and 1.6 mg/kg heroin resulted in parallel shifts to the left in the cocaine dose-response function. Isobolographic analysis of these dose-response functions using ED50 and ED75 values revealed that the combinations of cocaine and heroin were dose-additive, except at the cocaine plus 1.6 mg/kg heroin combination. , which was infra-additive. Redetermination of the cocaine-only and heroin-only dose-response functions revealed no significant difference from the first determination. To assess the effects of naltrexone on cocaine- and heroin-induced suppression of milk drinking, rats were first administered four doses of naltrexone (0.1–0.8 mg/kg, i.p., 15 min pretreatment). Then, naltrexone doses were combined with a dose of heroin or cocaine that suppressed milk drinking (3.2 and 16 mg/kg, respectively). Naltrexone alone produced modest, but not dose-related, suppression of milk drinking, and had no reliable effect on suppression of milk drinking produced by 16 mg/kg cocaine. In contrast, naltrexone dose-dependently blocked heroin-induced suppression of milk drinking and, at naltrexone doses that had no effect on milk drinking when administered alone, produced a parallel shift to the right in the heroin dose-response function. In vivo apparent pKB analyses revealed that naltrexone antagonism of heroin-induced suppression of milk drinking involved μ-opioid receptors. Taken together, these results suggest that the effects of cocaine and heroin on milk drinking are either dose-additive or infra-additive and that cocaine-induced suppression of milk drinking does not directly involve the μ-opioid receptor system.