Miracle-dz/UniFAR-FTUs huggingface dataset:
Serine proteinase inhibitors in human skeletal muscle: Expression of β‐amyloid protein precursor and α1‐antichymotrypsin in vivo and during myogenesis in vitro

The balance of serine proteases and inhibitors in nerve and muscle is altered during programmed‐ and injury‐induced remodeling. A serpin, α1‐antichymotrypsin (α1‐ACT), and Kunitz‐inhibitor containing forms of the β‐amyloid precursor protein (βAPP) may be important components of this balance. In the present study, we analyzed their expression in primary cultures of human myogenic (satellite) cells that mimic myogenic differentiation using Western blotting and immunocytochemistry. In vitro results were compared to in vivo results from normal adult human skeletal muscle biopsies. Using an anti‐α1‐ACT polyclonal antibody, we detected a 62 kDa immunoreactive band both in cultured human myogenic cells (mononucleated myoblasts as well as multi‐nucleated myotubes) and in extracts of human muscle biopsies. With a polyclonal anti‐βAPP antibody we found two bands (105 and 120 kDa) in myoblasts and myotubes in culture. However, the same antibody recognized only a single band at 92 kDa in biopsies. By immunocytochemistry, both α1‐ACT and βAPP were indistinctly present on localized to the surface of myoblasts in culture. In contrast, these inhibitors were dense on myotube surfaces, where they often formed distinct aggregates and frequently co‐localized. In permeabilized muscle cells, α1‐ACT and βAPP appeared to be localized to the perikarya of both myoblasts and myotubes. Confirming previous results, both α1‐ACT and βAPP were present at the neuromuscular junction in human muscle sections. These developmental changes found during in vitro myogenesis for α1‐ACT and βAPP, both serine protease inhibitors, reinforce the hypothesis that regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation. © 1995 Wiley‐Liss Inc.
RESPONSE MEAN UPCROSSING RATE FOR LINEAR MDOF SYSTEMS SUBJECTED TO FULLY NONSTATIONARY EARTHQUAKE GROUND MOTION MODEL

New explicit closed-form solutions are derived for the mean upcrossing rate of nonstationary response quantities of linear elastic, both classically and non-classically damped, multi-degree-of-freedom (MDOF) systems subjected to a fully nonstationary earthquake ground motion process. The stochastic earthquake ground motion model used in this study captures the temporal variation of both the amplitude and frequency content typical of real earthquake ground motions. The analytical results obtained are applied to single-degree-of-freedom (SDOF) systems and a three-dimensional unsymmetrical building equipped with viscous bracings. Each of the stochastic earthquake processes used in the application examples was calibrated against an actual earthquake record.
An Adaptable Indoor Flight Test Implementation for small UAVs

In this paper, an adaptable indoor flight test implementation for small unmanned aerial vehicles (UAVs) with motion capture system (Mocap) is illustrated. By generating pulse position modulation (PPM) signals which conform to multi-protocol compatible radio control (RC) module, it enables control of commonly available commercial RC products which usually do not provide application program interface (API) to users. A PPM signal reader which receiving the exact same signal as the onboard receiver is constructed into the system to measure the signal latency, control signal loss and to retrieve the trim value for different manoeuvres of any specific aircraft. The implementation and results of commanded trajectories (circle, figure ”8” and parabolic paths) were tested to explore the viability and adaptability of the presented method.
ANTIFUNGAL ACT IVITY OF CARICA PAPAYA SEED EXTRACT AGAINST ASPERGILLUS FLAVUS AS SERIOUS MYCOTOXINS PRODUCING ORGANISM AND CAUSAL ORGANISM FOR ASPERGILLOSIS

Aqueous Carica papaya seed extract was investigated for its ant ifungal activi ty against Aspergillus f lavus using cut plug method. C. papaya seed extract has inhibi tory activi ty against A. f lavus with inhibition zones ranging between 11 to 16 mm. A. f lavus cell s surviving ratio was decreased with increasing the C. papaya seed extract concentrations from 25 to 200 mg/ml. Treating the organism with C. papaya seed ext ract led to an external changes, i rregular cel l shape and disintegration of fungus cell wal l under transmission electron microscope. On other hand, studying the effect of the aqueous C. papaya seed extract on mice lung has showed safe effect which might explore in lung disease treatment. Furthermore C. papaya had antioxidant characters. Analysis by GCMS showed at least 15 components, esters were the most abundant group of compounds.
IMPROVED COATING PROPERTIES AND OPTIMIZED SUBSTRATE DATA , ESSENTIAL CONDITIONS FOR HIGH PERFORMANCE CUTTING TOOLS

S u m m a r y The fatigue and the wear behavior of coatings with various mechanical strength and thickness, on cemented carbide substrates are investigated experimentally in milling and analytically using a Finite Elements Method (FEM) simulation. The hereby-required coatings and substrates mechanical properties are determined by means of FEM supported evaluation procedure of nanoindentation test results. The initiation and progress of the coating and tool wear, for all the investigated cases, were studied using scanning electron microscopy and energy dispersive X-ray spectroscopy. Further investigations using a novel (Ti,Al)N based Supernitride PVD coating, with an AlN content close to the conductivity limit of 65-67mol-% AlN, were conducted and the results extracted are compared to the corresponding ones of an effective state of the art (Ti46Al54)N coating, thus demonstrating a superior performance of the Supernitride coating, especially at elevated cutting temperatures. The oxidation resistance growth, as well as the deterioration of the thermal conductivity though the increasing of the AlN content was taken into account to depict enhanced cutting performance of the examined supernitride coating. Through the reconditioning of worn coated cutting tools by means of appropriate de-coating, microblasting and physical vapour deposition (PVD) recoating procedures, a production cost decreasing is intended. However, the cutting performance of recoated tools may be impaired compared to the corresponding one of new tools, due to the fact that during the reconditioning processes strength properties modifications in the substrates are induced, resulting in a potential wear behaviour deterioration. In this way, the cutting performance reliability and in general the tool cost management could be unfavourably affected. In the investigations described, the previously mentioned procedure based on nanoindentations and a finite elements method (FEM) supported evaluation of the corresponding measurement results is applied. This method enables the determination of related internal stress alterations at every stage of reconditioning procedures. The occurring surface stress modifications in cemented carbides inserts during reconditioning procedures might affect the tool cutting performance. Investigations in milling and gear hobbing showed that the inferiority of the tool wear behaviour when using reconditioning cemented carbides tools, could be drastically reduced. The methodology introduced, contributes to the achievement of this target, since it facilitates the accurate assessment of the reconditioning procedures effect on the tool mechanical properties.
Application of Torsional Vibration Measurement to Shaft Crack Monitoring in Power Plants

Abstract : The primary goal of the this project was to demonstrate the feasibility of detecting changes in shaft natural frequencies (such as those associated with a shaft crack) on rotating machinery in electric power generation plants using non-contact, non-intrusive measurement methods. During the operation of power plant equipment, torsional natural frequencies are excited by turbulence, friction, and other random forces. This paper primarily addresses the results of field application of non-intrusive torsional vibration sensing to a hydro station and to large induced-draft (ID) fan motors. Testing reaffirmed the potential of this method for diagnostics and prognostics of shafting systems. The first few shaft natural frequencies were visible, and, for the hydro station, correlated well with finite element results (finite element results are not available for the ID fan motors). In addition, several issues related to the development of the non- intrusive transducer were revealed.
Measuring the accuracy of the AMIGA muon counters at the Pierre Auger Observatory

The AMIGA enhancement of the Auger Surface Detector consist s of a 23.5 km2 infilled area where the shower particles are sampled by water Cherenkov detecto rs accompanied by 30 m 2 of scintillator counters, buried 2.3 m underground. The accuracy of the muon counting o btained by the buried detectors is a basic element in the reconstruction procedure, and must be determined usi ng experimental air shower data. To perform this measurement, twin muon counters (30+30 m 2) have been deployed in two infill locations; their mutual dis tance being about 10 m, they sample nearly the same region of the air shower. In this paper we discuss the basic properties of the modules as measured during the constructi on phase and the expected counting performances of the twin counters installed at the experimental site.
Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: A randomized controlled trial*

Objectives:To evaluate the efficacy and safety of short-term low-dose intravenous haloperidol for delirium prevention in critically ill elderly patients after noncardiac surgery. Design:Prospective, randomized, double-blind, and placebo-controlled trial in two centers. Setting:Intensive care units of two large tertiary teaching hospitals. Patients:Four hundred fifty-seven patients 65 yrs or older who were admitted to the intensive care unit after noncardiac surgery. Intervention:Haloperidol (0.5 mg intravenous bolus injection followed by continuous infusion at a rate of 0.1 mg/h for 12 hrs; n = 229) or placebo (n = 228) was randomly administered from intensive care unit admission. Measures:The primary end point was the incidence of delirium within the first 7 days after surgery. Secondary end points included time to onset of delirium, number of delirium-free days, length of intensive care unit stay, all-cause 28-day mortality, and adverse events. Delirium was assessed using the confusion assessment method for the intensive care unit. Results:The incidence of delirium during the first 7 days after surgery was 15.3% (35/229) in the haloperidol group and 23.2% (53/228) in the control group (p = .031). The mean time to onset of delirium and the mean number of delirium-free days were significantly longer (6.2 days [95% confidence interval 5.9−6.4] vs. 5.7 days [95% confidence interval 5.4−6.0]; p = .021; and 6.8 ± 0.5 days vs. 6.7 ± 0.8 days; p = .027, respectively), whereas the median length of intensive care unit stay was significantly shorter (21.3 hrs [95% confidence interval 20.3−22.2] vs. 23.0 hrs [95% confidence interval 20.9–25.1]; p = .024) in the haloperidol group than in the control group. There was no significant difference with regard to all-cause 28-day mortality between the two groups (0.9% [2/229] vs. 2.6% [6/228]; p = .175). No drug-related side effects were documented. Conclusions:For elderly patients admitted to intensive care unit after noncardiac surgery, short-term prophylactic administration of low-dose intravenous haloperidol significantly decreased the incidence of postoperative delirium. The therapy was well-tolerated.
AN INVERSION METHOD TO DETERMINE STRESS DISTRIBUTION ON A FAULT PLANE USING GROUND MOTIONS

The rupture process of an earthquake has large effect on near-field ground motions. Because source-time functions are affected by the stress drop process, it is important to understand the dynamic rupture process of earthquake faults to estimate near-field ground motions. Kinematic inversion analyses have been carried out to obtain spatiotemporal slip distributions, from which the stress distributions on the fault plane have been inferred. In this study, an inversion method to infer stress drop process of an earthquake fault is developed. To express a spatiotemporal stress distribution on an earthquake fault during an earthquake, a fault is divided into subfaults and the shear stress on a subfault after the passage of the rupture front is assumed to change repeatedly to its residual stress. Stress changes of subfaults are inferred directly from the observed ground motions. Total rupture processes are composed of the stress change histories of the subfaults. To examine the performance of the method, a simulation test was conducted. A relatively simple model was used in the simulation and the computed synthetics were used as observed seismograms. The inversion was stabilized by adding smoothing constraints and ABIC was employed to objectively determine the optimal values of hyperparameters. The inferred time histories of stress changes on subfaults fit generally well with the assumed rupture process.
Microarray technology

The normal functions of the cells are based on a strict and regulated expression of various genes. If this precise hierarchy of gene actions becomes unregulated or disturbed due to different genetic or environmental effects, the result will be abnormal cellular function that eventually could lead pathological alterations, including carcinogenic transformation or apoptosis. To understand the complex mechanisms and networks involved in biological processes and diseases, it is not enough to analyze isolated pathways, single gene functions or a single genetic event. A living organism has to be studied as a complex system and all genes involved in different biological processes need to be analyzed simultaneously: a systems biology approach should be applied. In the beginning of the 1990’s years, a new, high throughput technology called microarray technology – was developed to measure the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome. Microarrays have dramatically accelerated many types of investigation since a microarray experiment can accomplish many genetic tests in parallel. This review summarizes some of aspects of the microarray technology, including sample preparations, application possibilities and data analysis. Acta Biol Szeged 59(Suppl.1):51-67 (2015) Key wordS aCGH DNA microarray functional genomics gene expression profile Submitted March 8 2015; Accepted June 9, 2015 *Corresponding author. E-mail: pusi@brc.hu
DEVELOPMENT OF AN ARTIFICIAL DYNAMIC FACE APPLIED TO AN AFFECTIVE ROBOT

 Facial expressions are fundamental to social relationships. Thus, socially affective robots are developed to express and recognize emotions, considering six basic facial expressions: happiness, sadness, disgust, fear, anger and surprise, besides the neutral state. The objective of this work is to develop and validate an artificial dynamic face for an affective robot to interact with humans. For this, a robot face is composed of simple humanoid features, besides different colors and animations. 101 adults and 328 children and teenagers evaluated the six facial expressions of the robot. The results demonstrate that the recognition average rate is greater than 85%. Keywords Affective robot, artificially dynamic face, facial expressions
Solitons , Shockwaves and Spikes : Computational Simulation of Nonlinear Waves on Lattice

Abstract In this paper, we systematically find computational solutions to a class of differential equation systems which exhibit nonlinear wave behavior. After discretizing the nonlinear partial differential equations, we got nonlinear dynamical systems on a lattice. Using MATLAB, we utilized both an ODE and Algorithm solver method to get explicit solutions with soliton and shockwave behavior. Using a 64 particle model, we plotted and animated our results in several forms, including a linear lattice, a ring lattice (when appropriate) and phase plots. Furthermore, our use of an algorithm solver yielded three-dimensional plots of shockwave evolution. Our calculations include the Fermi-Pasta-Ulam model, the Toda Exponential Lattice, the Inviscid Burgers Equation and the Hodgkin-Huxley Model. Using previously calculated lattices, we experimented with controls and feedbacks, including the Sine-Gordon Equation and the Gabov-Shefter Rosales integro-differential equation. We concluded our research with Split Domain calculations and the introduction of a memory-less computation method.
TÜMELAKTİF DEMİYELİNİZAN LEZYONLARA SAHİP MULTİPL SKLEROZ HASTALARINDA NÖRÖNAL YÜZEY ANTİKORLARI NEURONAL SURFACE ANTIBODIES ARE NOT FOUND IN MULTİPLE SCLEROSIS PATIENTS WITH TUMEFACTIVE DEMYELINATING LESIONS

Tümefaktif demiyelinizan lezyon (TDL); 2 cm veya daha fazla çapa sahip kütlesel etki, perilezyonal ödem ve halkasal yapı ile karakterize beyin lezyonudur. TDL zaman zaman multipl skleroz (MS) ve nöromiyelitis optika (NMO) hastalarında gözlemlenmektedir. Aquaporin 4 (Aqp-4) ve nöronal yüzey antijenlerine (iyon kanalları ve diğer nöronal membran proteinleri) karşı üretilen antikorlarının TDL patogenezinde rolü olup olmadığını belirlemek için TDL'na sahip yineleyendüzelen MS (relapsing-remitting MS; RRMS) hastalarında anti-nöronal ve nöronal hücre yüzey antikorlarını taradık.
Intervention in two rhyme priming tasks

We report results from two experiments in which the effects of rhyme prime (RP) are investigated by manipulating the properties of the interveners between prime and target. Studies of visual priming report that interveners have differing effects depending on the types of processing they require; we extend this line of inquiry to the auditory domain. Results suggest that RP is affected by the types of processing required for interveners: intervening tones are less disruptive interveners than more complex nonwords. We relate this finding to the syllabic representations (or the process building them), and outline directions for further work.
Loosely Coupled Stereo Inertial Odometry on Low-cost System

— We present a fast and robust stereo visual inertial odometry system which is friendly for low cost sensor and single board computer (SBC). Comparing against other research which uses tightly coupled algorithms or nonlinear optimization to increase accuracy in custom powerful hardware or desktop environment, our system adopts the loosely coupled ESKF to limit the computational complexity in order to ﬁt limited CPU resources and run in real-time on an ARM based SBC. The experiments demonstrates our method could be implemented in both indoor and outdoor scenarios with competitive accuracy. Furthermore, the usage of forward facing stereo cameras also provides the ability of obstacles avoidance. The result are released as an open sourced Robot Operation System (ROS 1 ) package.
Simulation and Control of a Tandem Tiltwing RPAS Without Experimental Data

The tandem tiltwing is one of many aircraft configurations providing vertical takeoff and landing (VTOL). This configuration is expected to be especially suitable for missions requiring VTOL capability combined with high range and space for payload. In this article, an overview of the simulation process of a tandem tiltwing remotely piloted aircraft system (RPAS) without experimental data and its control is given. Contrary to custom, the flight dynamic model, especially the whole aerodynamics model, consists of theoretical equations and interpolations depending on estimated parameters. Compared to complex wind tunnel tests, this approach is less expensive. In order to stabilize the unstable flight characteristics of the tandem tiltwing, a linearquadratic regulator (LQR) is designed. As the change of operating point of this VTOL aircraft is significant, the LQR has to be gain scheduled. For that, multiple trim points during the transition are ascertained making a controlled transition possible. However, due to the lack of test data, the probability of failure caused by an inaccurate flight controller relying on the flight dynamic model is increased. Hence, a robustness analysis of the closed-loop system is conducted, where the probability of stability of the closedloop real RPAS is estimated by a Monte Carlo method. For this purpose, all uncertain model parameters are changed based on the normal distribution by defining their standard deviation.
HOMEOWNERSHIP, HOME FORECLOSURE, AND NATIVITY: EVIDENCE FROM MIAMI-DADE COUNTY, FLORIDA.

In housing research as in employment, education, or demographic research, a central theme is the identification of gaps in outcomes and a desire to understand the extent to which these gaps are due to mutable individual characteristics. A well-developed strand of housing literature, for example, addresses the gap in homeownership between white, non-Hispanics and other groups and asks how much of that gap can be attributed to discrimination and how much is actually explained by other, changeable factors such as group age structure, geographical location, or educational attainment. A key variable in explaining gaps in homeownership has been nativity— the fact that large proportions of some groups simply have not lived in the United States long enough to transition to homeownership—and nativity and homeownership has developed into a sub-branch of housing research all its own.
MAGIC reveals structures in the gamma-ray emission of the unidentified gamma-ray source HESS J 1857 + 026

HESS J1857+026 is an extended TeV gamma-ray source that was discovered by H.E. S.S. close to the Galactic plane. Given its spatial coincidence with the young energetic pulsar PSR J1856+0245, the source might represent a pulsar wind nebula (PWN). Based on data from Fermi-LAT, H.E. S.S. and MAGIC a spectral break in the gamma-ray emission is evident around 100 GeV. Earlier results show that a leptonic dominated PWN scenario implies a low magnetic field, while a hadronic scenario is also able to explain the observed emission. HESS J1857+026 was observed by MAGIC in 2010, yielding about 30 hours of good quality stereoscopic data that resulted in a highly significant detection. We present a detailed analysis of the source morphology in two different energy regimes. We find a clear structure in the source above 1 TeV, which can not be explained with a simple PWN scenario. Here we will present the results of a multiwavelength search for possible counterparts associated to the TeV morphology.
Dialogue Systems Domain Interaction Using Reinforcement Learning

This paper describes research about using a reinforcement learning approach to optimize our Domain Knowledge Manager (DKM) that is part of a mixed-initiative task based Spoken Dialogue System (SDS) architecture, namely to access an Ambient Intelligence (AmI) scenario. Assuming that practical dialogue and domain-independent hypothesis are true, we have considered a clear separation between discourse dependent and domain dependent knowledge, which allows reducing the complexity of SDS typical components, specially the Dialoguer Manager (DM). In this context, we believe that is possible to get better DM strategies optimizing the interaction between DM and DKM. For this, we propose a new feature, for the DKM, based on learning and suggest the best task-artifact pairs to satisfy a DM query using the DM feedback as reward. The proposed DKM feature has been tested in our simulator based on Portuguese language.