Miracle-dz/UniFAR-FTUs huggingface dataset:
Cancer Therapy : Clinical Phase II Study of Dasatinib in Relapsed or Refractory Chronic Lymphocytic Leukemia

Purpose:Chronic lymphocytic leukemia (CLL) cells treatedwith dasatinib in vitro undergo apoptosis via inhibition of Lyn kinase. Thus, in this study we tested the activity of dasatinib in patients with relapsed CLL. Experimental Design: Patients were eligible for this phase II trial if they had documented CLL/SLL and had failed at least 1 prior therapy with a fludarabine-containing regimen and if they required therapy according to NCI-WG criteria. The starting dose of dasatinib was 140 mg daily. Results: Fifteen patients were enrolled, with a median age of 59 and a median of 3 prior regimens. All patients had received fludarabine, and 5 were fludarabine-refractory. Eleven of the 15 (73%) had high risk del(11q) or del(17p) cytogenetics. The primary toxicity was myelosuppression, with grade 3 or 4 neutropenia and thrombocytopenia in 10 and 6 patients, respectively. Partial responses by NCI-WG criteria were achieved in 3 of the 15 patients (20%; 90%CI: 6–44). Among the remaining 12 patients, 5 had nodal responses by physical exam, and 1 patient had a nodal and lymphocyte response but with severe myelosuppression. Pharmacodynamic studies indicated apoptosis in peripheral bloodCLL cells within 3 to 6 hours after dasatinib administration, associated with downregulation of Syk (spleen tyrosine kinase)
Effect of emotional valence on episodic memory stages as indexed by event-related potentials

Several investigations have shown that emotional events show superior recall than non-emotional ones. However, the cortical mechanisms underlying the episodic recall of emotional scenes are still poorly understood. Our main aim was to compare the magnitude of the Event-Related brain Potentials (ERP) old-new effect related to emotionally unpleasant, pleasant and neutral photographic images. As expected, correct recognition of all types of images elicited three topographically distinct ERP components sensitive to the classical old-new recognition effect. The results revealed that the behavioral performances were mainly sensitive to arousal, while the ERP old/new effect over posterior regions (300 – 1000 ms) was exclusively affected by unpleasantness. A later component (1000 – 1400 ms) showed an inverted old/ new effect at parietal sites, which was also sensitive to unpleasantness. These results imply that ERP reflecting episodic conscious recollection and post-retrieval monitoring are clearly affected both by valence and arousal.
VirtualSoC

Architectural heterogeneity has proven to be an effective design paradigm to cope with an ever-increasing demand for computational power within tight energy budgets, in virtually every computing domain. Programmable manycore accelerators are currently widely used not only in high-performance computing systems, but also in embedded devices, in which they operate as coprocessors under the control of a general-purpose CPU (the host processor). Clearly, such powerful hardware architectures are paired with sophisticated and complex software ecosystems, composed of operating systems, programming models plus associated runtime engines, and increasingly complex user applications with related libraries. System modeling has always played a key role in early architectural exploration or software development when the real hardware is not available. The necessity of efficiently coping with the huge HW/SW design space provided by the described heterogeneous Systems on Chip (SoCs) calls for advanced full-system simulation methodologies and tools, capable of assessing various metrics for the functional and nonfunctional properties of the target system. In this article, we describe VirtualSoC, a simulation tool targeting the full-system simulation of massively parallel heterogeneous SoCs. We also describe how VirtualSoC has been successfully adopted in several research projects.
Treatment of Alloxan-Induced Diabetic Rats with Metformin orGlitazones is Associated with Amelioration of Hyperglycaemia andNeuroprotection

Neurobehavioural and cognitive impairments are reportedly associated with both types of diabetes mellitus; and the structural and molecular aberrations in support of these are emerging. In the present study, we report the effects of induced diabetes and its treatment with or without oral hypoglycaemic drugs on the morphology and oxidative stress status of the prefrontal cortex. Hyperglycaemia was induced in fasted Wistar rats with alloxan (150 mg/kg body weight). Hyperglycaemic rats were treated with or without oral hypoglycaemic drugs (metformin, 150 mg/kg/d; pioglitazone, 3 mg/kg/d; and rosiglitazone, 10 mg/kg/d). At 28 days of treatment, prefrontal morphology was studied by the cresyl fast violet (CFV) and luxol fast blue (LFB) techniques; and malondialdehyde (MDA) and superoxide dismutase (SOD) were assayed in prefrontal homogenate. Blood glucose was estimated by the glucose oxidase method. Prefrontal cortex neurons showed weak affinity for CFV and LFB in the untreated diabetic rats; as opposed to the relatively strong affinity for these stains in the non-diabetic control rats and diabetic rats on oral hypoglycaemic interventions. In the latter, blood glucose was not significantly different (P>0.05) from the control at 28 days of treatment. Moreover, prefrontal MDA and SOD were not significantly different between all the groups (P>0.05). These findings suggest that morphologic aberrations are provoked by untreated diabetes mellitus, even in the absence of oxidative stress; and that oral hypoglycaemic interventions are neuroprotective in alloxan-induced diabetic rats.
Visual Single Cluster of multidimensional data

The rapid development of computer tools allows the computer system to stoke very large amount of data with many parameters such as electronic payment systems, sensors and monitoring systems and other. We talk about large data bases along both dimensions: number of recordings and number of dimensions "attribute, variable". Analysis of these data becomes very important and difficult in the same time. The visual data analysis has great potential applications because it facilitates the analysis, interpretation, validation and also increases the cognitive aspect among analysts. However, the traditional techniques of visualization of multidimensional data, such as parallel coordinates, glyphs, and scatter plot matrices, do not scale well to a very large data set. The increasing size and complexity of data sets is a new challenge and a key motivation for our works. In this article, we present our proposal approach VSCDR (Visual Single Cluster Dimension Reduction Approach) that can handle with big data.
Design and development of an embedded aeronautical router with security capabilities

Aeronautical communications are growing in complexity: avionic systems are more and more connected together through complex networks inside and outside the aircraft. This increase of connections requires highly secure systems to solve the constraints of such network topologies. In this paper, we present the IP based Secure Next Generation Router (SNG router) we have developed, providing regulation, routing, secure merging of different data sources and preserving of their segregation. During the design process we searched for a set of solutions to minimize the certification, design and development costs and maintain a high level of security. This paper is organized as follow: we first introduce the methodology we applied to the SNG router and its benefits. Then we examine the partition in charge of the security of data exchanged through the router. The paper is finished with the validation of our router's implementation and with the evaluation of our router's performances.
Removal Of Blurred And Illuminated Face Image With Different Poses

Face recognition has been researched field of computer vision for the past twenty years. This work have addressed the matter of recognizing blurred and poorly well-lighted faces. The set of all pictures obtained by blurring a given image may be a umbellate set given by the umbellate hull of shifted versions of the image. Supported this set-theoretic characterization, the work planned a blur-robust face recognition rule DRBF. This rule will simply incorporate previous information on the kind of blur as constraints. Determining the low-dimensional linear topological space model for illumination, the work showed that the set of all pictures obtained from a given image by blurring and ever-changing its illumination conditions may be a bi-convex set. Again, supported this set-theoretic characterization, this work planned a blur and illumination strong rule IRBF. The face below completely different create are often detected and normalized by mistreatment transformation parameters to align the input create image to frontal read. When finishing the said create social control method, the ensuing final image undergoes illumination social control. This is often performed mistreatment the SQI rule. Then face are often recognized mistreatment incorporating blur and illumination by classifying coaching and testing knowledge by mistreatment SVM.
A Semantic Mapping Representation and Generation Tool Using UML for System Engineers

To address the problem of semantic heterogeneity, there has been a large body of research directed to the study of semantic mapping technologies. Although various semantic mapping technologies have been investigated, facilitating the process for domain experts to perform a semantic data integration task is not an easy task. This is because one is required not only to possess domain expertise but also to have a good understanding of knowledge engineering. This work proposes an abstract semantic mapping representation using UML for undertaking ontology mapping. The aim is to enable domain experts (particularly system engineers) to undertake mappings using the proposed UML representation that they are familiar with, while ensuring accuracy and ease of use of the automatically generated mappings. The proposed UML representation is evaluated through usability experiments (undertaken by system engineers) using a developed tool that was developed to implement the propose approach. The results show that the participants could correctly undertake the mapping task using the proposed UML representation and that the tool generated correct and executable mappings.
Using Redundant Threads for Fault Tolerance of OpenMP Programs

As the wide application of multi-core processor architecture in the domain of high performance computing, fault tolerance for shared memory parallel programs becomes a hot spot of research. For years, checkpointing has been the dominant fault tolerance technology in this field, and recently, many research works have been engaged with it. However, to those programs which deal with large amount of data, checkpointing may induce massive I/O transfer, which will adversely affect scalability. To deal with such a problem, this paper proposes a fault tolerance approach, making use of redundancy, for shared memory parallel programs. Our scheme avoids saving and restoring computational state during the program's execution, hence does not involve I/O operations, so presents explicit advantage over checkpointing in scalability. In this paper, we introduce our approach and the related compiler tool in detail, and give the experimental evaluation result.
Path Following with Adaptive Path Estimation for Graph Matching

Graph matching plays an important role in many fields in computer vision. It is a well-known general NP-hard problem and has been investigated for decades. Among the large amount of algorithms for graph matching, the algorithms utilizing the path following strategy exhibited state-of-art performances. However, the main drawback of this category of algorithms lies in their high computational burden. In this paper, we propose a novel path following strategy for graph matching aiming to improve its computation efficiency. We first propose a path estimation method to reduce the computational cost at each iteration, and subsequently a method of adaptive step length to accelerate the convergence. The proposed approach is able to be integrated into all the algorithms that utilize the path following strategy. To validate our approach, we compare our approach with several recently proposed graph matching algorithms on three benchmark image datasets. Experimental results show that, our approach improves significantly the computation efficiency of the original algorithms, and offers similar or better matching results.
Making SME greedy and pragmatic

The Structure-Mapping Engine (SME) has successfully modeled several aspects of human analogical processing. However, it has two significant drawbacks : (1) SME constructs all structurally consistent interpretations of an analogy . While useful for theoretical explorations, this aspect of the algorithm is both psychologically implausible and computationally inefficient . (2) SME contains no mechanism for focusing on interpretations relevant to an analogizer's goals . This paper describes modifications to SME which overcome these flaws . We describe a greedy merge algorithm which efficiently computes an approximate "best" interpretation, and can generate alternate interpretations when necessary. We describe pragmatic marking, a technique which focuses the mapping to produce relevant, yet novel, inferences . We illustrate these techniques via example and evaluate their performance using empirical data and theoretical analysis.
An outbreak of occupational asthma due to chromium and cobalt.

BACKGROUND Five metal turners employed by an aerospace manufacturer presented to the Birmingham Chest Clinic occupational lung disease unit. Four cases of occupational asthma (OA) due to chromium salt (3) and cobalt (1) were diagnosed by serial peak-expiratory flow measurements and specific inhalation challenge testing. AIMS To measure the extent of the outbreak and to provide epidemiological data to ascertain the aetiology. METHODS Participants answered a detailed, self-administered questionnaire, designed to detect occupational lung disease. Urine chromium and cobalt excretion, spirometry and exhaled nitric oxide measurements were taken. Those with possible, probable or definite non-OA or OA, after questionnaire, were invited to undertake two-hourly peak flow measurements and received specialist follow-up. RESULTS A total of 62 workers (95% of workforce) participated. Sixty-one per cent of employees were working in higher metalworking fluid (MWF) exposure areas. Ninety per cent of workers had urinary chromium excretion indicating occupational exposure. Sixty-six per cent of workers reported active respiratory symptoms, although there were no significant differences between exposure groups. Two further workers with probable OA were identified and had significantly higher urinary chromium and cobalt concentration than asymptomatic controls. Eighteen cases of occupational rhinitis (OR) were identified, with significantly raised urinary chromium concentration compared with asymptomatic controls. CONCLUSIONS Chromium salt and cobalt can be responsible for OA and OR in workers exposed to MWF aerosols. Onset of symptoms in those with positive specific challenges followed change in MWF brand. Workers with OA had increased urinary concentrations of chromium and cobalt, and those with OR had increased urinary concentrations of chromium.
Resource discovery and intelligent image retrieval in a distributed environment

Remote sensing satellites are generating large amounts of (image) data at different levels of temporal, spatial and spectral resolution, with varying levels of detail, and at various stages of processing with a variety of algorithms. This bewildering array of data sources is going to mandate a new class of information retrieval systems to help end-users access the networked information resources effectively. We propose intelligent agent based mechanisms to locate the appropriate sources of satellite data, processing algorithms, and ancillary data that may be required at various levels of processing to answer different types of temporal and spatial queries.
Cortical Activation during Perception of a Rotating Wide-Field Acoustic Stimulus

We describe sound stimuli that produce the perception of complete rotation around the head. Such stimuli are analogous to wide-field motion stimuli used in visual research, though auditory stimuli, unlike visual stimuli, can be perceived at any point around the head; they are the only cues for spatial perception behind the subject. Using PET on six subjects, we have compared regional brain activity during the perception of such motion stimuli, with the perception of a control stimulus producing equivalent amplitude changes without rotation. Rotation produced activation of the premotor cortex bilaterally and the right superior parietal cortex. The premotor activation involved the frontal eye fields and ventral premotor areas. The bifrontal and right parietal activation is consistent with previous demonstrations of activation within a frontoparietal network of areas during perception of a linear motion stimulus. The inferior premotor activation in this experiment may reflect preparation for head turning in response to auditory targets that cannot be tracked visually.
HRD Practices and Philosophy of Management in Indian Organizations

The managerial philosophy of a company is generally based upon the top management's assumptions about people working in the organization. It reflects the attitude of the top management towards the human resources of an organization. Managerial philosophies of companies are embedded in the society. McGregor (1960) has labelled these managerial philosophies as ‘Theory X and Theory Y. ’ This paper is an attempt to identify the relationship between human resource (HR) practices and the philosophy of management of the Indian business organizations. For this, the different variables of HR practices were studied and the management's philosophy was identified by measuring beliefs of top management about employees in the organizations. The sample for the study consisted of 95 respondents from two private sector organizations and 119 respondents from two public sector organizations. The findings of the study indicate that the variables of HR practices (planning, recruitment, and selection) were highly but negatively related to the philosophy of management in the private sector organizations. This meant that the Indian organizations were practising traditional philosophy of management in such organizations. The prevalence of traditional managerial philosophy focusing on managerial control has always dominated the managerial community in the sense that it is more prevalent and is more ‘tightly’ linked to managerial practice. As new managerial ideologies evolved, the older ones “never disappeared; instead, images and practices central to each were gradually institutionalized” (Barley and Kunda, 1992). The philosophy of management showed a blurred picture in the public sector organizations. Though the top management's views and balance sheet emphasized the belief of the organization towards Theory Y, the analysed responses proved that management philosophy was not clear to managers working in these organizations. In fact, the Indian public sector organizations started as welfare organizations. However, the impact of market economy has led to a competitive environment. Though the public sector organizations have started realizing the impact of competition, it is difficult for them to understand when they lost their focus on the managerial philosophy. The following key issues emerged from the study: Organizations will have to design managerial philosophy which is sensitive to human existence. The managerial philosophy in the organization has an impact on the organizations of the future. HR concepts that get packaged along with modern managerial philosophy are likely to revolutionize the workplace. The bottom line is that people want to be cared for and respected. On their part, organizations want commitment and integrity. A successful combination of committed people and a benevolent organization could well be the way for organizations in this competitive environment in India.
Menurunkan Konsep Ontologi Mullâ Shadrâ Ke Dalam Filsafat Ketuhanan

Dalam QS.18:110 terinformasikan bahwa salah satu syarat berjumpa dengan Tuhan ialah tidak melakukan kesyirikan. Dan untuk menjamin tindakan kita masuk katagori syirik atau tidak syirik niscaya berilmu. Dan ontologi Mullâ Shadrâ (Ashâlah Al-Wujûd dan Tasykîk Al-Wujûd) dapat dijadikan landasan merumuskan Tauhid yang lurus, sehingga dengannya dapat diperoleh pengetahuan jaminan syirik dan tidak syirik. Dalam konteks inilah nilai penting menurunkan ontologi Mullâ Shadrâ (Ashâlah Al-Wujûd dan Tasykîk Al-Wujûd) ke dalam Filsafat Ketuhanan, yang dengannya dapat diturunkan konspsi Tauhid.
A New Multi-Resonant Frequency Microstrip Antenna with U-Shaped Patch for Wireless Communication

This paper presents the investigation of a new square patch antenna. In the designed antenna a U-shaped square patch has been constructed, and nelco material substrate is used in the designed antenna for multiple resonances. It is a light weight, low profile, low volume, easily mounted and low fabrication cost antenna. In this proposed antenna, we have achieved 4 resonances of -50.40db, -42db, -27.92db and -21.83db at a frequency of 5.21Ghz, 5.98Ghz, 5.55Ghz and 4.36Ghz respectively. The maximum achieved gain of the designed antenna is 7.
Creditor Control of Free Cash Flow

With free cash flows, borrowers can accumulate cash or voluntarily pay down debts. However, sometimes creditors impose a mandatory repayment covenant called "excess cash flow sweep" in loan contracts to force borrowers to repay debts ahead of schedule. About 17 percent of borrowers in the authors' sample (1995-2006) have this covenant attached to at least one of their loans. The author finds that the sweep covenant is more likely to be imposed on borrowers with higher leverage (i.e., where risk shifting by equity holders is more likely). The results are robust to including borrower fixed effects or using industry median leverage as a proxy. The covenant is more common also in borrowers where equity holders appear to have firmer control, e.g., when more shares are controlled by institutional block holders, when firms are incorporated in states with laws more favorable to hostile takeovers, or when equity holders place higher valuation on excess cash holdings. These determinants suggest that the sweep covenant may be motivated by creditor-shareholder conflicts. Finally, the author shows that the covenant has real effects: borrowers affected by the sweep covenant indeed repay more debts using excess cash flows, and they spend less in capital investment and pay out fewer dividends to shareholders.
Development of a Source Code Analysis Environment Focusing on Security

In the past years, the expressive increase in the d ev lopment of computer technologies has been follow ed by an increasing number of systems being probed, infected , ompromised and used to launch attacks on other s ystems. Successful attacks against computer systems are due to the exploitation of some kind of vulnerability. Poor programming techniques are the main cause of vulner abilities. The more common vulnerabilities are: