Miracle-dz/UniFAR-FTUs huggingface dataset:
Polarization Dependent Reflectivity and Transmission for Cd1-Xznxte/GaAs(001) Epifilms in the Far-Infrared and Near-Infrared to Ultraviolet Region

The results of a comprehensive experimental and theoretical study is reported to empathize the optical properties of binary GaAs, ZnTe, CdTe and ternary Cd1-xZnxTe (CZT) alloys in the two energy regions: (i) far-infrared (FIR), and (ii) near-infrared (NIR) to ultraviolet (UV). A high resolution Fourier transform infrared spectrometer is used to assess the FIR response of GaAs, ZnTe, CdTe and CZT alloys in the entire composition 1.0 ≥ x ≥ 0 range. Accurate model dielectric functions are established appositely to extort the optical constants of the binary materials. The simulated dielectric functions ei¥(ω) and refractive indices n~(ω) are meticulously appraised in the FIR → NIR → UV energy range by comparing them against the existing spectroscopic FTIR and ellipsometry data. These outcomes are expended eloquently for evaluating the polarization dependent reflectivity R(λ) and transmission T(λ) spectra of ultrathin CZT/GaAs (001) epifilms. A reasonably accurate assessment of the CZT film thickness by reflectivity study has offered a credible testimony for characterizing any semiconducting epitaxially grown nanostructured materials of technological importance.
Pectoralis myocutaneous flap for replacement of cervical esophagus

The authors report experience with 10 cases of pharyngoesophageal replacement with tubed pectoralis major myocutaneous (PM) flap. Six patients had primary reconstruction following total pharyngolaryngectomy for cancer; the other 4 had severe pharyngoesophageal stenosis requiring resection and replacement following previous laryngectomy. Seven of the patients were octogenarians, 6 had been irradiated previously, and all were severely debilitated. Two patients died postoperatively of cardiac disease. The remaining eight regained satisfactory with lasting deglutition. Four fistulae healed spontaneously, and one postoperative stenosis responded to a single dilitation. The interval to swallowing was 10‐21 days in nonirradiated patients and 3‐13 weeks in irradiated patients. There was one local recurrence 6 months after resection; the other patients remained free of disease. The authors conclude that the tubed PM flap is a reliable technique for pharyngoesophageal reconstruction that is particularly useful in elderly and debilitated patients.
The Force of Union: Affect and Ascent in the Theology of Bonaventure

The image of love as a burning flame is so widespread in the history of Christian literature as to appear inevitable. But as this dissertation explores, the association of amor with fire played a precise and wide-ranging role in Bonaventure’s understanding of the soul’s motive power--its capacity to love and be united with God, especially as that capacity was demonstrated in an exemplary way through the spiritual ascent and death of St. Francis. In drawing out this association, Bonaventure develops a theory of the soul and its capacity for transformation in union with God that gives specificity to the Christian desire for self-abandonment in God and the annihilation of the soul in union with God. Though Bonaventure does not use the language of the soul coming to nothing, he describes a state of ecstasy or excessus mentis that is possible in this life, but which constitutes the death and transformation of the soul in union with God. In this ecstatic state, the boundaries between the soul and God--between active and passive, mover and moved, will and necessity--are effectively consumed in the fire of union. This dissertation offers a new approach to the role of affect in Bonaventure’s theology through three lenses: his elaboration of the soul’s union with God as inspired by the writings of Dionysius the Areopagite; Bonaventure’s conception of synderesis or the soul’s natural affective “weight” or inclination to God; and the ecstatic death of the soul that Bonaventure describes in iii
Combination therapy for multidrug‐resistant cytomegalovirus disease

Multidrug‐resistant (MDR) cytomegalovirus (CMV) emerged after transient responses to ganciclovir, foscarnet, and cidofovir in a CMV‐seropositive recipient who underwent allogeneic hematopoietic stem cell transplantation from a CMV‐seronegative donor. Experimental treatments using leflunomide and artesunate failed. Re‐transplantation from a CMV‐seropositive donor supported by adoptive transfer of pp65‐specific T cells and maribavir was followed by lasting suppression. This case illustrates that successful MDR CMV therapy may require individualized multidisciplinary approaches.
Exploring Disease Association from the NHANES Data: Data Mining, Pattern Summarization, and Visual Analytics

Finding associations among different diseases is an important task in medical data mining. The NHANES data is a valuable source in exploring disease associations. However, existing studies analyzing the NHANES data focus on using statistical techniques to test a small number of hypotheses. This NHANES data has not been systematically explored for mining disease association patterns. In this regard, this paper proposes a direct disease pattern mining method and an interactive disease pattern mining method to explore the NHANES data. The results on the latest NHANES data demonstrate that these methods can mine meaningful disease associations consistent with the existing knowledge and literatures. Furthermore, this study provides summarization of the data set via a disease influence graph and a disease hierarchical tree.
Quantum search by local adiabatic evolution

The adiabatic theorem has been recently used to design quantum algorithms of a new kind, where the quantum computer evolves slowly enough so that it remains near its instantaneous ground state, which tends to the solution. We apply this time-dependent Hamiltonian approach to Grover’s problem, i.e., searching a marked item in an unstructured database. We find that by adjusting the evolution rate of the Hamiltonian so as to keep the evolution adiabatic on each infinitesimal time interval, the total running time is of order AN, where N is the number of items in the database. We thus recover the advantage of Grover’s standard algorithm as compared to a classical search, scaling as N. This is in contrast with the constant-rate adiabatic approach of Farhi et al. ~e-print quant-ph/0001106! , where the requirement of adiabaticity is expressed only globally, resulting in a time of order N.
ORIGINAL INVESTIGATIONS Pathogenesis and Treatment of Kidney Disease Low Medication Adherence and Hypertension Control Among Adults With CKD: Data From the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study

Background: Low adherence to antihypertensive medication is an important barrier to achieving blood pressure control. Few data are available for medication adherence in adults with chronic kidney disease (CKD). Study Design: Cross-sectional. Setting & Participants: 3,936 and 9,129 participants with and without CKD using antihypertensive medication in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study, respectively. CKD was defined as albuminuria with albumin excretion 30 mg/g or estimated glomerular filtration rate 60 mL/min/1.73 m 2 . Outcomes: Medication adherence and uncontrolled hypertension. Measurements: Medication adherence was assessed using a validated 4-item scale. Blood pressure was measured 2 times by trained staff. Results: In REGARDS participants with and without CKD, 1,426 (36.2%) and 2,421 (26.5%) had uncontrolled hypertension with blood pressure 140/90 mm Hg, and 2,656 (67.5%) and 5,627 (61.6%), 130/80 mm Hg. Also, 27.7% of those with CKD and 27.9% of those without CKD responded “yes” to ever forgetting to take their medication and 4.4% and 4.2%, respectively, responded yes to being careless about taking their medication. Also, 5.7% and 5.3% responded yes to missing taking medication when they felt better, and 4.2% and 3.6%, to missing it when they felt sick. Overall, 23.3% and 23.7% of participants with and without CKD responded yes to 1 adherence question, whereas 7.7% and 7.2%, respectively, responded yes to 2 or more adherence questions. In those with CKD, the multivariable adjusted ORs for uncontrolled hypertension (blood pressure 140/90 mm Hg) for individuals answering yes to 1 and 2 or more versus 0 adherence questions were 1.26 (95% CI, 1.05-1.51) and 1.49 (95% CI, 1.12-1.98), respectively. Analogous ORs for systolic/diastolic blood pressure 130/80 mm Hg were 1.06 (95% CI, 0.78-1.45) and 1.20 (95% CI, 0.88-1.64). Limitations: Pharmacy fill data were not available. Conclusions: Individuals with CKD had similarly poor medication-taking behaviors as those without CKD. Am J Kidney Dis 56:447-457. ©2010 by the National Kidney Foundation, Inc.
Optimizing Air-Core Permanent-Magnet-Based Energy Harvest in Free-Rotating Devices

This paper details the analysis and design of an air-core permanent-magnet-based energy-harvest system for use within an in-pipe mobile water-quality sensor. The sensor is a free-moving/free-rotating device of which the energy-harvest system occupies an appreciable volume. Therefore, the electrical and mechanical dynamics of the device are strongly coupled, which poses a modeling challenge. To address this challenge, a rigorous electrical/mechanical model is established to determine expected energy harvest, given the geometric/material parameters and electrical/mechanical inputs. The model was utilized within a single-objective optimization-maximizing energy harvested from impacts-to design a prototype, which was constructed and used for model validation. Subsequently, multiobjective optimizations were performed to establish the tradeoff between energy harvest versus device volume and impact-based versus rolling-based energy-harvest efficacy.
Disentangling the complex broad-band X-ray spectrum of IRAS 13197-1627 with NuSTAR, XMM-Newton and Suzaku

We present results from a coordinated XMM–Newton+NuSTAR observation of the type 1.8 Seyfert galaxy IRAS 13197−1627. This is a highly complex source, with strong contributions from relativistic reflection from the inner accretion disc, neutral absorption and further reprocessing by more distant material, and ionized absorption from an outflow. We undertake a detailed spectral analysis combining the broad-band coverage provided by XMM–Newton+NuSTAR with a multi-epoch approach incorporating archival observations performed by XMM–Newton and Suzaku. Our focus is on characterizing the reflection from the inner accretion disc, which previous works have suggested may dominate the AGN emission, and constraining the black hole spin. Using lamppost disc reflection models, we find that the results for the inner disc are largely insensitive to assumptions regarding the geometry of the distant reprocessor and the precise form of the illuminating X-ray continuum. However, these results do depend on the treatment of the iron abundance of the distant absorber/reprocessor. The multi-epoch data favour a scenario in which the AGN is chemically homogeneous, and we find that a rapidly rotating black hole is preferred, with a* ≥ 0.7, but a slowly rotating black hole is not strongly excluded. In addition to the results for the inner disc, we also find that both the neutral and ionized absorbers vary from epoch to epoch, implying that both have some degree of inhomogeneity in their structure.
Determination of solar ultraviolet dose in the Dead Sea treatment of psoriasis.

BACKGROUND An increased risk of developing cancer of the skin is the only potentially serious (albeit unproven) long-term side effect of heliotherapy and it is therefore prudent to avoid unnecessary exposure to solar ultraviolet radiation. Traditional heliotherapy for psoriasis at the Dead Sea calls for a sun exposure of 5-6 hours daily for 28 days. Studies have determined that mid-summer exposure for 3 hours is equally effective. OBJECTIVES To determine the effect of 3 hours sun exposure daily in the heliotherapy of psoriasis at the Dead Sea during the months March to December; and to monitor the associated ambient doses of solar UVB radiation. METHODS A total of 194 patients with moderate to severe psoriasis was treated in the months of March to December by 3 hours of sun exposure each day. The dose of ambient solar UVB was monitored by a Solar Model 501A UVB-Biometer. RESULTS Three hours of sun exposure daily was therapeutically efficacious in all months from March to November, but not in December. The lowest effective cumulative UVB dose was 170 SED (standard erythema dose), recorded in March and November. CONCLUSIONS Daily sun exposure for the heliotherapy of psoriasis at the Dead Sea can be reduced to at least 3 hours daily, about half the time originally recommended.
Predictions of Carbamazepine Concentrations Using a Bayesian Program (PKS System, Abbott): A Retrospective Evaluation in an Outpatient Population

This work evaluates the performance of a Bayesian program (PKS System, Abbott) for predicting carbamazepine concentrations in an outpatient population. The retrospective study involved 20 epileptic patients (12 adults and 8 children) receiving carbamazepine monotherapy orally. The program was used to predict measured serum levels after feedback of 0, 1 or 2 steady‐state concentrations.
On Latent Growth Models for Composites and Their Constituents

Over the last decade and a half, latent growth modeling has become an extremely popular and versatile technique for evaluating longitudinal change and its determinants. Most common among the models applied are those for a single measured variable over time. This model has been extended in a variety of ways, most relevant for the current work being the multidomain and the second-order latent growth models. Whereas the former allows for growth function characteristics to be modeled for multiple outcomes simultaneously, with the degree of growth characteristics' relations assessed within the model (e.g., cross-domain slope factor correlations), the latter models growth in latent outcomes, each of which has effect indicators repeated over time. But what if one has an outcome that is believed to be formative relative to its indicator variables rather than latent? In this case, where the outcome is a composite of multiple constituents, modeling change over time is less straightforward. This article provides analytical and applied details for simultaneously modeling growth in composites and their constituent elements, including a real data example using a general computer self-efficacy questionnaire.
p150 Overexpression in gastric carcinoma: The association with p53, apoptosis and cell proliferation

To clarify the significance of p150 expression, 102 gastric carcinomas were immunohistochemically investigated and 14 fresh samples of the cancer were analyzed with the immunoblot method. Tumor cell apoptosis was assessed by terminal deoxynucleotidyl transferase (TdT)‐mediated dUTP‐digoxigenin nick end labeling (TUNEL). Both Ki‐67 antigen and p53 expression were analyzed immunohistochemically. Eighty‐six out of 102 (85%) gastric cancers stained positively for p150. All 14 tumors analyzed by Western blotting overexpressed p150. Statistical analysis revealed a close association between p150 overexpression and the clinicopathologic parameters of gastric cancer. All well‐differentiated cancers showed high p150 expression (p < 0.005). Furthermore, high p150 expression was more frequently seen in tumors at early invasive stages (p < 0.005), in tumors without metastases (both local and distant, p < 0.005) and in early TNM stages (p < 0.005) in general. As we have found for cervix and esophagus carcinoma, when tumors progress to high malignancy and metastasis, p150 begins to regress and then breaks down. A good correlation of p150 expression, but not p53 expression, with tumor cell apoptosis could be demonstrated (p < 0.01). The Ki‐67 labeling index, i.e., the index for a proliferative marker, showed no correlation with either p150 or p53 expression. The results suggest that p150 may be a new early tumor marker for gastric carcinoma similar to that for esophagus and cervix carcinoma. © 2004 Wiley‐Liss, Inc.
Crime analytics: Analysis of crimes through newspaper articles

Crime analysis is one of the most important activities of the majority of the intelligent and law enforcement organizations all over the world. Generally they collect domestic and foreign crime related data (intelligence) to prevent future attacks and utilize a limited number of law enforcement resources in an optimum manner. A major challenge faced by most of the law enforcement and intelligence organizations is efficiently and accurately analyzing the growing volumes of crime related data. The vast geographical diversity and the complexity of crime patterns have made the analyzing and recording of crime data more difficult. Data mining is a powerful tool that can be used effectively for analyzing large databases and deriving important analytical results. This paper presents an intelligent crime analysis system which is designed to overcome the above mentioned problems. The proposed system is a web-based system which comprises of crime analysis techniques such as hotspot detection, crime comparison and crime pattern visualization. The proposed system consists of a rich and simplified environment that can be used effectively for processes of crime analysis.
A functional genomics approach to the study of alkaloid biosynthesis and metabolism in

The aim of this work was to improve understanding of the regulation of alkaloid biosynthesis in two Solanaceae plants, Nicotiana tabacum (tobacco) and Hyoscyamus muticus (Egyptian henbane). In order to map the biosynthetic genes involved in the tobacco alkaloid pathway, a functional genomics-based technology was established by combining genome-based transcript profiling (cDNA-AFLP) with targeted metabolite analysis. Altogether 459 genes were found to be differentially expressed in methyl jasmonate-elicited N. tabacum BY-2 cells. Homology searches performed with these genes revealed that 58 % of the genes displayed similarity with genes having known functions, whereas no sequence similarity was found with 26 % of the genes, suggesting that some of them may take part in unknown steps in tobacco alkaloid biosynthesis. Alkaloids accumulated 12 hours after methyl jasmonate application, with varying kinetic patterns. For the first time the alkaloid anatalline was shown to accumulate in Nicotiana cell cultures, and together with anatabine they formed the main alkaloid pool. Anatalline was further characterized structurally as being present in two isomeric forms, anatalline and trans-2,4-di(3-pyridyl)piperidine. Contrary to the case in whole tobacco plants, nicotine was only a minor alkaloid accumulating in elicited cells, whereas the production of a precursor methylputrescine was highly induced. Based on these results, it was suggested that the limiting step in nicotine biosynthesis occurred between methylputrescine and nicotine. Altogether 34 methyl jasmonate-modulated genes were selected for further functional testing in BY-2 cell cultures using Agrobacterium-mediated gene transformation. Six genes caused a lower alkaloid accumulation compared to the control when assayed in cell cultures, whereas three genes elevated the production of one or several alkaloids. One of the genes causing enhanced
Sirtuin 7 Plays a Role in Ribosome Biogenesis and Protein Synthesis*

It has been shown that SIRT7 regulates rDNA transcription and that reduced SIRT7 levels inhibit tumor growth. This anti-tumor effect could be due to reduced Pol I activity and perturbed ribosome biogenesis. In this study, using pulse labeling with RNA and amino acid analogs, we found that SIRT7 knockdown efficiently suppressed both RNA and protein synthesis. Surprisingly, SIRT7 knockdown preferentially inhibited protein synthesis over rDNA transcription, whereas the levels of both were reduced to similar extents following Pol I knockdown. Using an affinity purification mass spectrometry approach and functional analyses of the resulting SIRT7 interactome, we identified and validated SIRT7 interactions with proteins involved in ribosomal biogenesis. Indeed, SIRT7 co-fractionated with monoribosomes within a sucrose gradient. Using reciprocal isolations, we determined that SIRT7 interacts specifically with mTOR and GTF3C1, a component of the Pol III transcription factor TFIIIC2 complex. Further studies found that SIRT7 knockdown triggered an increase in the levels of LC3B-II, an autophagosome marker, suggesting a link between SIRT7 and the mTOR pathway. Additionally, we provide several lines of evidence that SIRT7 plays a role in modulating Pol III function. Immunoaffinity purification of SIRT7-GFP from a nuclear fraction demonstrated specific SIRT7 interaction with five out of six components of the TFIIIC2 complex, but not with the TFIIIA or TFIIIB complex, the former of which is required for Pol III–dependent transcription of tRNA genes. ChIP assays showed SIRT7 localization to the Pol III targeting genes, and SIRT7 knockdown triggered a reduction in tRNA levels. Taken together, these data suggest that SIRT7 may regulate Pol III transcription through mTOR and the TFIIIC2 complex. We propose that SIRT7 is involved in multiple pathways involved in ribosome biogenesis, and we hypothesize that its down-regulation may contribute to an antitumor effect, partly through the inhibition of protein synthesis.
MMPTCP: a novel transport protocol for data centre networks

Modern data centres provide large aggregate capacity in the backbone of networks so that servers can theoretically communicate with each other at their maximum rates. However, the Transport Control Protocol (TCP) cannot efficiently use this large capacity even if Equal-Cost Multi-Path (ECMP) routing is enabled to exploit the existence of parallel paths. MultiPath TCP (MPTCP) can effectively use the network resources of such topologies by performing fast distributed load balancing. MPTCP is an appealing technique for data centres that are very dynamic in nature. However, it is ill-suited for handling short flows since it increases their flow completion time. To mitigate these problems, we propose Maximum MultiPath TCP (MMPTCP), a novel transport protocol for modern data centres. Unlike MPTCP, it provides high performance for all network flows. It also decreases the bursty nature of data centres, which is essentially rooted in traffic patterns of short flows. MMPTCP achieves these nice features by randomising a flow’s packets via all parallel paths to a destination during the initial phase of data transmission until a certain amount of data is delivered. It then switches to MPTCP with several subflows in which data transmission is governed by MPTCP congestion control. In this way, short flows are delivered very fast via the initial phase only, and long flows are delivered by MPTCP with several subflows. We evaluate MMPTCP in a FatTree topology under various network conditions. We found that MMPTCP decreases the loss rate of all the links throughout the network and helps competing flows to achieve a better performance. Unlike MPTCP with a fixed number of subflows, MMPTCP offers high burst tolerance and low-latency for short flows while it maintains high overall network utilisation. MMPTCP is incrementally deployable in existing data centres because it does not require any modification to the network and application layers.