Miracle-dz/UniFAR-FTUs huggingface dataset:
One-year clinical outcomes of patients implanted with a Resolute Onyx™ zotarolimus-eluting stent

Objective To evaluate the 1-year clinical outcomes of patients who received the Resolute Onyx™ stent. Methods This was a single-centre, retrospective registry analysis that reviewed the clinical data from all patients who were implanted with a Resolute Onyx™ stent between March 2015 and February 2016. Clinical follow-up was performed at 1 year post-implantation. Results A total of 252 patients received a Resolute Onyx™ stent and two patients were lost to follow-up. The mean age of the cohort was 66.9 years and 113 (45.2%) had diabetes mellitus. Thirty-eight patients (15.2%) had left main disease and 73 (29.2%) had three-vessel disease. A total of 175 patients (70.0%) had small vessel disease (<2.75 mm) and 210 (84.0%) had long lesions (>20 mm). The 1-year target lesion failure was 4.4% (11 of 250), cardiovascular death occurred in eight patients (3.2%), ischaemia-driven target lesion revascularization was undertaken in five patients (2.0%) and stent thrombosis occurred in one patient (0.4%). Conclusion The Resolute Onyx™ stent showed a favourable 1-year clinical performance in a real-world population.
On the rôle of minimal typing derivations in type-driven program transformation

Standard inference algorithms for type systems involving ML-style polymorphism aim at reconstructing most general types for all let-bound identifiers. Using such algorithms to implement modular program optimisations by means of type-driven transformation techniques generally yields suboptimal results. We demonstrate how this defect can be made up for by using algorithms that target at obtaining so-called minimal typing derivations instead. The resulting approach retains modularity and is applicable to a large class of polyvariant program transformations.
Optimal Generation of Space–Time Trellis Codes via Coset Partitioning

Criteria for designing good space-time trellis codes (STTCs) have been developed in previous publications. However, the computation of the best STTCs is time consuming, because a long exhaustive or systematic computing search is required, particularly for a high number of states and/or transmit antennas. To reduce the search time, an efficient method must be employed to generate the STTCs with the best performance. In this paper, a technique called coset partitioning is proposed to easily and efficiently design optimal 2n-phase-shift keying (PSK) STTCs with any number of transmit antennas. Coset partitioning is an improved extension to multiple-input-multiple-output (MIMO) systems of the set partitioning proposed by Ungerboeck. This extension is based on the lattice and coset Calderbank approach. With this method, optimal blocks of the generator matrix are obtained for 4-PSK and 8-PSK codes. These optimal blocks lead to the generation of the STTCs with the best Euclidean distances between the codewords. Thus, new codes are proposed with three to six transmit antennas for 4-PSK modulation and with three and four transmit antennas for 8-PSK modulation. These new codes outperform the corresponding best known codes. In addition, the first 4-PSK STTCs with seven and eight transmit antennas and the first 8-PSK STTCs with five and six transmit antennas are given, and their performance is evaluated by simulation.
Humane non-human primate model of traumatic spinal cord injury: quantitative analysis of electromyographic data.

A valid non human primate model of traumatic spinal cord injury (TSCI) is essential to evaluate and develop new treatments. In previous experiments, it has been demonstrated that a transmitter can be implanted in the macaque fasicularis monkey that measures electromyographic data from the musculature of the tail. As well, previous experiments have demonstrated that selective lesions can be created in the lower thoracic spinal cord that does not cause limb weakness and/or bowel dysfunction. The histopathological features of these lesions appear similar to human TSCI. This paper describes a method by which the EMG data can be transformed into a quantitative metric of volitional limb movement (“Q”). This metric permits an objective assessment of injury, natural recovery as well as potential efficacy of candidate treatments.
Monitoring patients with HIV disease

From early in the human immunodeficiency virus (HIV) pandemic it was noted that a long subclinical latent phase preceded the appearance of opportunist infections. The use of immune monitoring to prompt prophylactic agents considerably reduced morbidity caused by opportunist infection1 in the 1980s. In the past few years, as new antiretroviral treatments emerged but were threatened by resistance, viral monitoring has been used to guide such treatment. Consensus guidelines on laboratory monitoring2,3 and treatment4 in HIV have been published on both sides of the Atlantic. In this article, we discuss the natural history of HIV infections, current immunological and virological tests, and recommendations for monitoring protocols.J Clin Pathol 2000;53:266–272 Efficient infection of T helper cells, macrophages, and dendritic cells by HIV requires expression of the CD4 molecule and chemokine receptors. In early infection, HIV is characteristically trophic for the CCR5 chemokine receptor on macrophages and dendritic cells, explaining why the 1% or so of the white population with a CCR5 polymorphism are relatively protected from HIV.5 Early HIV infection is characterised by active viral replication, with high amounts of viral RNA, recoverable virus, or viral antigens such as p24 being found.6 Subsequently, viraemia falls because specific cytotoxic T cells kill infected cells, replication is inhibited by non-lytic means, or the availability of uninfected target cells is exhausted.7,8 Thus, an initial precipitous fall in CD4+ cell counts may be followed by partial recovery at this stage. Although the amounts of virus in blood fall, replication continues in lymphoid tissue9 until a new steady state of viraemia is attained. The mean half life of the virus in the plasma is approximately two days,10,11 suggesting that the continual production of virus and target cells is matched by an equivalent rate of …
Sexual Orientation Discrimination in Medical Statistics

Over the past six months a new taperecorded telephone service has been available to Wellingtonians. The message describes the symptoms of various forms of venereal diseas~and advises callers of the times that they may attend the V.D. Clinic at Wellington Hospital. The service has had a remarkable number of calls, presumably because of the way in which it provides information hitherto not readily available. In that section of the tape-recorded message dealing with syphi.lis the following sentence occurs:
Data Clustering for Improving the Selection of Donors for Data Imputation

Riassunto: Il presente lavoro si inserisce nell’ambito dell’imputazione automatica dei dati effettuata per mezzo di dati esatti, detti donatori. Per ogni record errato, occorre selezionare un numero di donatori aventi particolari caratteristiche. Quando tale selezione deve essere effettata all’interno di serbatoi di potenziali donatori molto ampi, come nel caso di un censimento della popolazione, i tempi di calcolo possono rivelarsi troppo elevati. Al fine di ridurre il numero di potenziali donatori da esaminare, è qui proposto l’innovativo utilizzo di una procedura di clustering. L’insieme dei potenziali donatori viene diviso in numerosi sottoinsiemi, in modo che elementi dello stesso sottoinsieme abbiano caratteristiche simili. È stato in particolare sviluppato un algoritmo per il clustering di dati demografici. I risultati sono molto soddisfacenti, dal punto di vista sia della qualità dei dati, sia computazionale.
Design, implementation and evaluation of SDN-based resource management model

Usage of the Internet has been changed over the past decade. Current tightly-coupled network architecture limits innovative actions. Besides, companies desire to provide better service while keeping their costs low. Software Defined Networking (SDN) is a new approach that provides abstract, programmable and open networking. It is brought up to address these issues. In this study, we present the design, implementation and evaluation of pre-established multi-path (PMP) based intradomain routing and resource management model for SDN-based networks. PMPs are established between each pair of edge nodes. Controller performs routing, admission control and resource management based on these paths. The experimental works show that the proposed model provides scalable admission control, routing and significantly improves resource utilization.
Unholy Questions About Five Central Tenets of Psychoanalysis That Need to be Empirically Verified

Psychoanalysis is about asking the hard questions. This article applies this basic assumption of the clinical practice of psychoanalysis to the science of psychoanalysis. I focus on a number of key assumptions of psychoanalytic approaches and their epistemological status: (a) the theoretical language of psychoanalysis, (b) psychoanalytic technique and training, (c) psychoanalytic developmental theories, (d) object relational and attachment approaches within psychoanalysis, and (e) the nature of general explanatory models in psychoanalysis. These examples are far from exhaustive, but cover a broad set of historical and contemporary theoretical approaches within psychoanalysis. In asking “hard” questions about the epistemological status of these key assumptions, I emphasize the importance of the re-introduction of playfulness and the cherishment of novelty and innovation, so important for psychological development, in psychoanalytic thinking. Psychoanalysis, as any other scientific discipline, should not shy away from asking these hard questions. It should do so with frank openness and a playful attitude. If not, orthodoxy and rigidity, already widespread in some quarters within psychoanalysis, will lead to a degenerative program of research that will herald the downfall of psychoanalysis as an intellectual and clinical movement.
A STUDY ON THE MECHANISM OF INTERCELLULAR ADHESION

Aggregation of suspended HeLa cells is increased on removal of cell surface sialic acid. Calcium ions promote aggregation whereas magnesium ions have no effect. The calcium effect is abolished by previous treatment of the cells with neuraminidase. Trypsinization of the HeLa cells followed by thorough washing diminishes the rate of mutual cell aggregation. Subsequent incubation with neuraminidase restores the aggregation rate to the original value before trypsin treatment. Cells which had acquired a greater tendency for aggregation after removal of peripheral sialic acid lose this property when subsequently treated with trypsin. Calcium ions have no aggregative effect on trypsinized cells. In contrast to HeLa cells, aggregation of human erythrocytes was not increased after treatment with neuraminidase or on addition of calcium. The results with HeLa cells are interpreted as follows: (a) Trypsin-releasable material confers adhesiveness upon the cells. (b) The adhesive property of this material is counteracted by the presence of cell surface sialic acids. (c) Calcium ions exert their effect by attenuating the adverse effect of sialic acid.
K-band differential and quadrature digitally-controlled oscillator designs in SiGe BiCMOS technology

This paper presents the design of differential and phase-tunable quadrature K-band digitally-controlled oscillators (DCOs) utilizing a tunable-dielectric resonator structure, and preliminary measured results for the differential DCO. The prototype differential oscillator exhibits ~1 GHz of tuning range with eight digitally controlled states. The quadrature oscillator design has 256-state (8-bit) frequency control and a simulated phase tuning authority of > 30 degrees to correct for wide process and operating temperature variability.
A phylogenetic networks approach to the classification of English-based Atlantic creoles

This paper deals with the issue of genetic relationships between English-based Atlantic creoles. A method borrowed from biology will be applied to a set of lexical and structural features found in the sample presented in Hancock (1987) in order to assess the degrees of affinity between these languages and their evolutionary histories. We will argue that the phylogenetic networks approach proposed here is the most suitable for the classification of creole languages. At the same time, we will show that this tool can also be used to assess the degree of radicalness of a creole, another issue which has been at the heart of creole studies.
How have global shocks impacted the real effective exchange rates of individual euro area countries since the euro’s creation?

Abstract This paper uncovers the response pattern to global shocks of euro area countries’ real effective exchange rates before and after the start of Economic and Monetary Union (EMU), a largely open ended question when the euro was created. We apply to that end a newly developed methodology based on high dimensional VAR theory. This approach features a dominant unit to a large set of over 60 countries’ real effective exchange rates and is based on the comparison of two estimated systems: one before and one after EMU. We find strong evidence that the pattern of responses depends crucially on the nature of global shocks. In particular, post-EMU responses to global US dollar shocks have become similar to Germany’s response before EMU, i.e., to that of the economy that used to issue Europe’s most credible legacy currency. By contrast, post-EMU responses of euro area countries to global risk aversion shocks have become similar to those of Italy, Portugal or Spain before EMU, i.e., of economies of the euro area’s periphery. Our findings also suggest that the divergence in external competitiveness among euro area countries over the last decade, which is at the core of today’s debate on the future of the euro area, is more likely due to country-specific shocks than to global shocks.
Hoopl: Dataflow Optimization Made Simple

We present Hoopl, a Haskell library that makes it easy for compiler writers to implement program transformations based on dataflow analyses. The compiler writer must identify (a) logical assertions on which the transformation will be based; (b) a representation of such assertions, which should form a lattice of finite height; (c) transfer functions that approximate weakest preconditions or strongest postconditions over the assertions; and (d) rewrite functions whose soundness is justified by the assertions. Hoopl uses the algorithm of Lerner, Grove, and Chambers (2002), which can compose very simple analyses and transformations in a way that achieves the same precision as complex, handwritten “superanalyses. ” Hoopl will be the workhorse of a new back end for the Glasgow Haskell Compiler (version 6.12, forthcoming). Reviewers: code examples are indexed at http://bit.ly/jkr3K
The use of scores anchored at the scale midpoint in reporting individuals' traits

Standardized scores including factor scores are insufficient indicators of individuals' positions on personality traits when mean scores deviate considerably from the scale origin. Anchored scores, that is, raw scores expressed as deviations from the scale midpoint and divided by the standard deviation, retain this discrepancy. We argue in favour of reporting in terms of anchored scores in addition to standard scores, and present a solution to the specific problem of finding anchored factor (i.e., principal‐component) scores. Such scores are obtained through dividing factor weights by the standard deviation of the variable in question, and applying the corrected weights to the matrix of raw scores, expressed as deviations from the scale midpoint (e.g. −2, −1, 0, +1, +2). © 1998 John Wiley & Sons, Ltd.
The CLEF Corpus: Semantic Annotation of Clinical Text

The Clinical E-Science Framework (CLEF) project is building a framework for the capture, integration and presentation of clinical information: for clinical research, evidence-based health care and genotype-meets-phenotype informatics. A significant portion of the information required by such a framework originates as text, even in EHR-savvy organizations. CLEF uses Information Extraction (IE) to make this unstructured information available. An important part of IE is the identification of semantic entities and relationships. Typical approaches require human annotated documents to provide both evaluation standards and material for system development. CLEF has a corpus of clinical narratives, histopathology reports and imaging reports from 20 thousand patients. We describe the selection of a subset of this corpus for manual annotation of clinical entities and relationships. We describe an annotation methodology and report encouraging initial results of inter-annotator agreement. Comparisons are made between different text sub-genres, and between annotators with different skills.
Data sieving and collective I/O in ROMIO

The I/O access patterns of parallel programs often consist of accesses to a large number of small, noncontiguous pieces of data. If an application's I/O needs are met by making many small, distinct I/O requests, however, the I/O performance degrades drastically. To avoid this problem, MPI-IO allows users to access a noncontiguous data set with a single I/O function call. This feature provides MPI-IO implementations an opportunity to optimize data access. We describe how our MPI-IO implementation, ROMIO, delivers high performance in the presence of noncontiguous requests. We explain in detail the two key optimizations ROMIO performs: data sieving for noncontiguous requests from one process and collective I/O for noncontiguous requests from multiple processes. We describe how one can implement these optimizations portably on multiple machines and file systems, control their memory requirements, and also achieve high performance. We demonstrate the performance and portability with performance results for three applications-an astrophysics-application template (DIST3D) the NAS BTIO benchmark, and an unstructured code (UNSTRUC)-on five different parallel machines: HP Exemplar IBM SP, Intel Paragon, NEC SX-4, and SGI Origin2000.
Biomechanical Comparison of a Novel C1 Posterior Locking Plate With the Harms Technique in A C1–C2 Fixation Model

Study Design. A biomechanical testing protocol was used to study atlantoaxial fixation techniques in a human cadaveric model. Objective. To compare the in vitro biomechanics of locking plate fixation of the posterior arch of C1 to C2 laminar screw fixation, with that of conventional C1 lateral mass to C2 pars screw fixation. Summary of Background Data. Current methods of atlantoaxial fixation pose a risk to neurologic and vascular structures. A novel posterior locking plate for C1 was designed, that when rigidly linked to C2 translaminar screws may offer alternative C1–C2 fixation with greatly decreased surgical risk. No comparative in vitro biomechanical testing has been previously done to evaluate the feasibility of this method. Methods. Cadaveric and CT assessments of the thickness of the C1 ring were performed. Seven spines (C0–C4) were evaluated in flexion-extension, left-right bending, and left-right axial rotation in a cadaveric C1–C2 fixation model. Three conditions were evaluated: (1) intact spine, and after odontoidectomy, (2) C1 plate to C2 laminar screw fixation, (3) C1 lateral mass to C2 pars screw fixation. Flexibility and motion data were compared using a 1-way RM analysis of variance and Student-Newman-Kuels tests. Results. Anatomic data indicated that 6 mm of screw purchase was viable for C1 plate fixation. Both the Harms and C1-plated conditions significantly reduced global flexibility in flexion-extension and left-right axial rotation. Motion at the C1–C2 level was significantly reduced for all loading modes for both instrumented conditions with the exception of the C1 plate in right bending. No significant differences occurred between the 2 fixation methods. Conclusion. A novel C1 posterior locking plate was designed and tested in a C1–C2 fixation model. The C1 locking plate technique functioned in an equivalent manner to the existing Harms technique. The C1 plate may be a viable alternative that is technically less demanding with decreased surgical risk.
Personal Agents for Implicit Culture Support

We present an implementation of a multi-agent system that aims at solving the problem of tacit knowledge transfer by means of experiences sharing. In particular, we consider experiences of use of pieces of information. Each agent incorporates a system for implicit culture support (SICS) whose goal is to realize the acceptance of the suggested information. The SICS permits a transparent (implicit) sharing of the information about the use, e.g., requesting and accepting pieces of information.
Speaker verification using phoneme-adapted Gaussian Mixture Models

Despite intuitive expectation and experimental evidence that phonemes contain useful speaker discriminating information, phoneme-based speaker recognition systems reported so far were not found to perform better than phoneme-independent speaker recognition systems based on Gaussian Mixture Model (GMM). The paper proposes a new phoneme-based speaker verification technique that uses models obtained by adaptation of well-trained speaker GMMs. The new proposed system was found to consistently outperform comparable sized phoneme-independent GMM based speaker verification systems in experiments held with clean and telephone speech databases.
Additive manufacturing of scaffolds with sub-micron filaments via melt electrospinning writing

The aim of this study was to explore the lower resolution limits of an electrohydrodynamic process combined with direct writing technology of polymer melts. Termed melt electrospinning writing, filaments are deposited layer-by-layer to produce discrete three-dimensional scaffolds for in vitro research. Through optimization of the parameters (flow rate, spinneret diameter, voltage, collector distance) for poly-ϵ-caprolactone, we could direct-write coherent scaffolds with ultrafine filaments, the smallest being 817 ± 165 nm. These low diameter filaments were deposited to form box-structures with a periodicity of 100.6 ± 5.1 μm and a height of 80 μm (50 stacked filaments; 100 overlap at intersections). We also observed oriented crystalline regions within such ultrafine filaments after annealing at 55 °C. The scaffolds were printed upon NCO-sP(EO-stat-PO)-coated glass slide surfaces and withstood frequent liquid exchanges with negligible scaffold detachment for at least 10 days in vitro.
The suppression of ethical dispositions through managerial governmentality: A habitus crisis in Australian higher education

‘Fiscal’ and other so‐called ‘crises’ in Australian universities are more fundamentally, it is argued in this article, crises of government decision and ‘governmentality’. Using an illustrative ‘morality tale’ drawn from their working knowledge of the Australian university sector, the authors take a critically reflexive perspective, working from the sociological concepts of Pierre Bourdieu, to explore the significance of shifts in governance practices in the field of universities. The paper examines the crisis as it is lived and experienced at an inter‐subjective level: what Bourdieu calls ‘habitus’. It is argued that new ‘rules of the game’ are creating severe conflict within the dispositional constitution of professional identities, especially in the suppression of dispositions to be ethical agents in the everyday life of our own field of work. It is suggested that this analytical approach offers important directions for further research in the area of understanding organizational change, with implications for educational leadership.