Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictors of in-hospital outcomes after primary percutaneous coronary intervention for acute myocardial infarction in patients with a high Killip class.

OBJECTIVE The predictors of in-hospital outcomes after primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) complicated with heart failure or cardiogenic shock at presentation remain unclear. METHODS Using the AMI-Kyoto Multi-Center Risk Study database, the clinical background characteristics, angiographic findings, primary PCI results, and in-hospital prognoses were retrospectively compared between primary PCI-treated AMI patients with a Killip class status of ≥2 (Killip 2-4 patients, n=390) and those with a Killip class 1 status (Killip 1 patients, n=1,057). RESULTS The Killip 2-4 patients were more likely to have a higher age and proportion of women and exhibited a higher prevalence of previous myocardial infarction, diabetes mellitus and chronic kidney disease or anemia on admission, lower systolic blood pressure (SBP) values on admission, a higher rate of multivessels or left main trunk as the culprit artery, a larger number of diseased vessels, a lower Thrombolysis In Myocardial Infarction (TIMI) grade in the infarct-related artery (IRA) before/after primary PCI and a significantly higher in-hospital mortality rate than the Killip 1 patients. According to a multivariate analysis, age was found to be an independent positive predictor of in-hospital mortality, while admission SBP was an independent positive predictor of in-hospital survival in both groups. In contrast, anemia on admission was found to be an independent predictor of in-hospital death, while the TIMI 3 flow in the IRA after PCI was found to be an independent factor for survival in the Killip 2-4 patients, but not the Killip 1 patients. CONCLUSION Anemia on admission and the final TIMI 3 flow in the IRA are critical determinants of in-hospital death in AMI patients with a Killip class status of ≥2 undergoing primary PCI.
Draft Genome Sequence of a Methicillin-Resistant Sequence Type 39 Staphylococcal Isolate Obtained from Seafood

ABSTRACT The draft genome sequence of a methicillin-resistant Staphylococcus aureus (MRSA) sequence type 39 (ST 39) isolate obtained from the dried ribbonfish of Gujarat, India, is reported here. Staphylococcus-specific genes were present in this MRSA isolate. The whole-genome sequence of this strain contains 2,693 protein-coding genes and 70 RNAs within the 2.82-Mb genome.
Binding and interstitial penetration of liposomes within avascular tumor spheroids

The liposomal delivery of cancer therapeutics, including gene therapy vectors, is an area of intense study. Poor penetration of liposomes into interstitial tumor spaces remains a problem, however. In this work, the penetration of different liposomal formulations into prostate carcinoma spheroids was examined. Spheroid penetration was assessed by confocal microscopy of fluorescently labeled liposomes. The impact of liposomal surface charge, mean diameter, lipid bilayer fluidity and fusogenicity on spheroid penetration was examined. A variety of different liposome systems relevant to clinical or preclinical protocols have been studied, including classical zwitterionic (DMPC:chol) and sterically stabilized liposomes (DMPC:chol:DOPE‐PEG2000), both used clinically, and cationic liposomes (DMPC:DOPE:DC‐chol and DOTAP), forming the basis of the vast majority of nonviral gene transfer vectors tested in various cancer trials. Surface interactions between strongly cationic vesicles and the tumor cells led to an electrostatically derived binding‐site barrier effect, inhibiting further association of the delivery systems with the tumor spheroids (DMPC:DC‐chol). However, inclusion of the fusogenic lipid DOPE and use of a cationic lipid of lower surface charge density (DOTAP instead of DC‐chol) led to improvements in the observed intratumoral distribution characteristics. Sterically stabilized liposomes did not interact with the tumor spheroids, whereas small unilamellar classical liposomes exhibit extensive distribution deeper into the tumor volume. Engineering liposomal delivery systems with a relatively low charge molar ratio and enhanced fusogenicity, or electrostatically neutral liposomes with fluid bilayers, offered enhanced intratumoral penetration. This study shows that a delicate balance exists between the strong affinity of delivery systems for the tumor cells and the efficient penetration and distribution within the tumor mass, similar to previous work studying targeted delivery by ligand‐receptor interactions of monoclonal antibodies. Structure‐function relationships from the interaction of different liposome systems with 3‐dimensional tumor spheroids can lead to construction of delivery systems able to target efficiently and penetrate deeper within the tumor interstitium and act as a screening tool for a variety of therapeutics against cancer. © 2004 Wiley‐Liss, Inc.
Organic selenium enhances the antioxidative status and quality of cockerel semen under high ambient temperature

1. The objective was to examine the effect of supplemental dietary organic selenium (Se) on improving semen quality and antioxidative status in male domestic fowls exposed to high ambient temperature. 2. Thirty-six Egyptian local cross males, 42 weeks old, were housed individually in cages in an open-sided building under 16 h L:8 h D and were provided with commercial feed and water ad libitum. In the house average daily temperature ranged from 33 to 36°C and relative humidity from 60 to 70%. Birds were divided into 4 experimental treatments (n = 9) and were fed the basal diet supplemented with 0 (control), 0⋅1, 0⋅2 or 0⋅3 mg organic Se/kg in the form of a yeast source (Sel-Plex®) for 8 weeks. 3. Under heat stress conditions, inclusion of organic Se in the cockerel diets enhanced the semen quality traits, including the sperm count and motility and reduced the percentage of dead sperms in a dose-dependent manner. 4. In seminal plasma, organic Se supplementation ameliorated some of the adverse effects of heat stress on lipid peroxidation and antioxidative properties. The inclusion of organic Se (0⋅3 mg/kg) in the cockerel diets doubled seminal plasma glutathione peroxidase (GSH-Px) activity, compared to controls and reduced lipid peroxidation. 5. In conclusion, supplemental dietary organic Se improved semen quality characteristics when cockerels were subjected to heat stress. It increased both sperm count and motility, reduced the percentage of dead sperm and enhanced the antioxidative status of seminal plasma.
Simultaneous interpenetrating silicone hydrogel based on radical/addition polymerization for extended release of ocular therapeutics

Hydrogels with interpenetrating network (IPN) can overcome thermodynamic incompatibility and obtain transparent materials with limited phase separation. In this report, hydroxyl-grafting polysiloxane (HPSO) was synthesized and transparent silicone hydrogels with interpenetrating network were simultaneously prepared based on radical polymerization of methacrylic monomer of 3-methacryloxypropyl tris(trimethylsiloxy)silane/N,N-dimethylacrylamide and addition polymerization of HPSO/isophorone diisocyanate. The silicone hydrogels were characterized by dehydration kinetics, tensile tester, light transmittance, ion permeability, oxygen permeability, and lysozyme deposition. The results show that increasing the proportion of hydrophobic network of HPSO in the IPN silicone hydrogel decreases equilibrium swelling ratio, ion permeability, Young’s modulus, and lysozyme deposition; on the contrary, increased tensile strength, elongation at break and oxygen permeability. Puerarin and ketoconazole were used as models to evaluate the drug loading and in vitro release behavior of the silicone hydrogels. It is revealed that the amount of loaded drugs in the hydrogel decreases with the increase of HPSO network in the hydrogels. All the silicone hydrogels exhibit extended release behavior, especially for ketoconazole, the in vitro release is divided into two phases corresponding to the rapid release at initial 24 h and relatively slow release from 125 to 360 h.
Role of Id family proteins in growth control

Id proteins (inhibitors of DNA binding/differentiation) are negative regulators of basic helix‐loop‐helix (bHLH) type transcription factors, which promote the differentiation of various cell types. In addition to their “classical” ability to inhibit cell differentiation, they are able to stimulate cell cycle progression. These facts suggest that Id proteins play a role in keeping precursor cells immature and in expanding the cell population size during development. In vitro as well as in vivo analyses in the last several years have shown that Id proteins have more complex activities; they induce apoptosis or function as survival factors, depending on the cell context. Furthermore, dysregulated expression of Id proteins has been reported in several human tumors and seems to be related to the malignant character of tumors. Here, we summarize and discuss the biological activities of Id proteins from the standpoint of cell growth control. J. Cell. Physiol. 190: 21–28, 2002. © 2002 Wiley‐Liss, Inc.
Tests and Requirements, Requirements and Tests: A Möbius Strip

Writing acceptance tests early is a requirements engineering technique that can save time and money and help businesses better respond to change. We believe that concrete requirements blend with acceptance tests in much the same way as the two sides of a strip of paper become one side in a Mobius strip. In other words, requirements and tests become indistinguishable, so you can specify system behavior by writing tests and then verify that behavior by executing the tests. In this article, we purposely avoided describing the detailed syntax of FIT to demonstrate that knowledge of that syntax isn't required to read and understand the tests as requirements. This could lead you to believe that there is no syntax and that the tests are simply ad hoc conversions of narratives to tables. Requirements written in the FIT style are also tests.
An Indoor Positioning Method using IEEE 802.11 Channel State Information

In this paper, we propose an indoor positioning system that makes use of the attenuation model for IEEE 802.11 Channel State Information (CSI) in order to determine its distance from an Access Point (AP) at a fixed position. With the use of CSI, we can mitigate the problems present in the use of Received Signal Strength Indicator (RSSI) data and increase the accuracy of the estimated mobile device’s location. For the experiments we performed, we made use of the Intel 5300 Series Network Interface Card (NIC) in order to receive the channel frequency response. The Intel 5300 NIC differs from its counterparts in that it can obtain not only the RSSI but also the CSI between an access point and a mobile device. We can obtain the signal strengths and phases from subcarriers of a system which in turn means making use of this data in the estimation of a mobile device’s position.
Multi-criteria analysis of sustainable environmental clean technologies for the treatment of winery's wastewater

The current study deals with the application advanced oxidation process (AOP), as a clean technology for the treatment of winery's wastewater. In order to find out the best available technique (BAT) amongst several AOP, a multi criteria analysis was used. As key evaluation criteria the categories of costs, benefits, opportunities and risks, were applied, each one of them included a range of economic, environmental, technical and social sub-criteria. The final results indicated that the methods of homogeneous and heterogeneous photocatalysis can be applied satisfactorily to the treatment of wineries wastewater, resulting in reduction of total organic carbon in the range of 30% to 80%. The multi-criteria analysis indicated that, the homogeneous photocatalysis photo Fenton, predominates over other photocatalytic techniques due to the high rates of degradation of the organic load (80%). The application of a hybrid system combining homogeneous photocatalysis photo Fenton as a pre-treatment step followed by biological treatment is found to be relatively the optimal solution to resolve the problem of winery's wastewater treatment, resulting in more than 90% reduction of total organic load.
Perceptual Analysis in Different Voice Samples: Agreement and Reliability

The objective of this study was to estimate the agreement and reliability of voice evaluation by a group of expert listeners using the central portion of a sustained vowel and a fragment of connected speech as voice samples. Ratings were made using Wilson's Buffalo III Voice Screening Profile. Analysis showed that intraindividual listeners' agreement presented variability in the evaluation of both voice samples. In the evaluation of the central portion of the sustained vowel, intraindividual listener agreement was moderate for breathiness, hyponasal resonance, and overall voice rating; in connected speech, agreement was moderate for most voice qualities (breathy, rough, high/low pitch, and hyponasal resonance). Finally, Wilson's Buffalo III Voice Screening Profile presented good reliability values for both voice samples, with overall voice rating achieving higher values (.90) than any other voice-quality variable.
Exploring and Visualizing the History of InfoVis

The exploration and visualization of large information spaces is a challenging task. The provided contest data set for example contains more than 1000 authors of about 600 papers. The basic idea for an effective data exploration is to include the human in the data exploration process and combine the flexibility, creativity, and general knowledge of the human with the enormous storage capacity and the computational power of today’s computers. The key concept of our visualization approach is to visualize the whole dataset to provide a first overview and to provide rapid, incremental, and reversible analysis actions. Our techniques follow the well-known Information Seeking Mantra: overviews first, zoom and filter, and details on demand. All visualizations, actions, and details are tightly coupled using the well-known linking and brushing concepts.
Fine-needle Aspiration Cytology of the Breast

Fine-needle aspiration cytology (FNAC) is an established, highly accurate, and cost-effective method for diagnosing lesions in different organs, including the breast. The method is minimally invasive without unwanted side effects. FNAC forms part of the triple assessment of breast lesions. Despite some shortcomings of the reporting categories, FNAC as part of the triple assessment has proved its value in describing the findings most accurately. The diagnostic impact depends on experience of the operator, quality of preparation, and diagnostic skills of the cytopathologist. The highest accuracy is achieved at centers with a multidisciplinary approach. FNAC is often palpation guided from palpable breast masses, whereas ultrasonography guidance is more widely used on nonpalpable lesions. Inadequate sampling with FNAC is particularly seen in collagenous lesions and in submitted specimens sampled by physicians lacking experience with the FNAC procedure. A diagnostic biopsy is recommended when FNAC provides scant material. FNAC is considered to be a safe method for screening purposes, although moderately less sensitive than core needle biopsy. FNAC is most accurate when experienced cytopathologists are available to assess the adequacy of the aspirated material and advise on additional aspirations for ancillary tests when needed.
Supplementary for ECIR 2014 Paper “ Deep Learning for Character-based Information Extraction on Chinese and Protein Sequence ”

Table 1 summarizes some statistics of the datasets we used in experiments. (1) The CTB data we used for WS and POS is from Chinese Treebank 6.0 (LDC2007T36), released in 2007, encompasses 2,036 text files, containing 28,295 sentences, 781,351 words and about 1.3M Chinese characters. (2). The CITYU NER data was from SIGHAN3 [6], which includes around 1.8M NE-labeled Chinese characters. (3). The CB513 data for SS task consists of 513 unrelated proteins with known 3D structure. Totally the CB513 includes about 84k amino acid characters labeled with SS target tags [8].
The Challenge of Composition in Distributional and Formal Semantics

This is tutorial proposal. Abstract is as follows: The principle of compositionality states that the meaning of a complete sentence must be explained in terms of the meanings of its subsentential parts; in other words, each syntactic operation should have a corresponding semantic operation. In recent years, it has been increasingly evident that distributional and formal semantics are complementary in addressing composition; while the distributional/vector-based approach can naturally measure semantic similarity (Mitchell and Lapata, 2010), the formal/symbolic approach has a long tradition within logic-based semantic frameworks (Montague, 1974) and can readily be connected to theorem provers or databases to perform complicated tasks. In this tutorial, we will cover recent efforts in extending word vectors to account for composition and reasoning, the various challenging phenomena observed in composition and addressed by formal semantics, and a hybrid approach that combines merits of the two. Outline and introduction to instructors are found in the submission. Ran Tian has taught a tutorial at the Annual Meeting of the Association for Natural Language Processing in Japan, 2015. The estimated audience size was about one hundred. Only a limited part of the contents in this tutorial is drawn from the previous one. Koji Mineshima has taught a one-week course at the 28th European Summer School in Logic, Language and Information (ESSLLI2016), together with Prof. Daisuke Bekki. Only a few contents are the same with this tutorial. Tutorials on “CCG Semantic Parsing” have been given in ACL2013, EMNLP2014, and AAAI2015. A coming tutorial on “Deep Learning for Semantic Composition” will be given in ACL2017. Contents in these tutorials are somehow related to but not overlapping with our proposal.
A statistical analysis of behavioral bursts occurring in a social networking game

Computational social science is an emerging interdisciplinary field which uses computational techniques to model, simulate and analyze human behavior and social phenomena, typically by leveraging the power of big data. Some researchers in this field use the records of actions taken by players in online games, meaning that they obtain a large amount of human behavioral data without explicitly conducting experiments with human subjects. This study investigates the mechanism of a social phenomenon called behavioral bursts which occur in a social networking game with over 7 million players. We define a behavioral burst as an increase in average points obtained by players that goes over the estimated value by a threshold. The results show that the burst patterns are classified into two classes depending on their cause. One is exogenous burst, caused by external factors (e.g. end of events), and the other is endogenous burst, caused by player interaction. We then investigate the change in the behavior of players between before and during the bursts, and find that only a small number of players are involved in them in case of endogenous bursts. Furthermore, by focusing on the action sequences of players obtaining many points, we find that they communicate with other players in a modest number of times, and in the case of endogenous bursts they tend to exchange information with a fixed player.
Estudio nacional de huella hídrica Colombia sector agrícola

El proposito de este estudio es, mediante la conceptualizacion del indicador de Huella Hidrica, ayudar a fortalecer el posicionamiento de los diferentes sectores, sociedad civil, empresas y gobierno, frente al tema de la sostenibilidad del agua, mostrando impactos asociados al desarrollo de las actividades economicas y sociales y sus implicaciones frente a la sostenibilidad y disponibilidad del recurso hidrico, el cual se identifica como motor fundamental para el desarrollo social y economico del pais. En lo referente a la cuantificacion de cada uno de los componentes de la Huella Hidrica, se pretende hacer enfasis en el analisis individual de cada una: Huella Verde, Azul y Gris; identificando el potencial de informacion que ofrecen individualmente en lo relativo a sus impactos asociados a variables economicas, sociales y ambientales de los sectores productivos y consumidores de la zona estudiada; todo fuertemente orientado al caracter geografico explicito del indicador.
Flexible Spatial and Temporal Hedonic Price Indexes for Housing in the Presence of Missing Data

We propose a flexible hedonic methodology for computing house price indexes that uses multiple imputation (MI) to account for missing data (a huge problem in housing data sets). Ours is the first study to use MI in this context. We also allow for spatial correlation, include interaction terms between characteristics, between regions and periods, and between regions and characteristics, and break the regressions up into overlapping blocks of five consecutive periods (quarters in our case). These features ensure that the shadow prices are flexible both across regions and time. This flexible structure makes the derivation of price indexes from the estimated regression equations far from straightforward. We develop innovative methods for resolving this problem and for splicing the overlapping blocks together to generate the overall panel results. We then use our methodology to construct temporal and spatial price indexes for 15 regions in Sydney, Australia on a quarterly basis from 2001 to 2006 and combine them to obtain an overall price index for Sydney. Our hedonic indexes differ quite significantly from the official index for Sydney published by the Australian Bureau of Statistics. We also find clear evidence of convergence in prices across regions from 2001-3 (while prices were rising), and divergence thereafter. We conclude by exploring some of the implications of these empirical findings.
Long-term ambient multipollutant exposures and mortality.

RATIONALE population-based studies have demonstrated associations between ambient air pollution exposures and mortality, but few have been able to adjust for occupational exposures. Additionally, two studies have observed higher risks in individuals with occupational dust, gas, or fume exposure. OBJECTIVES we examined the association of ambient residential exposure to particulate matter less than 10 microm in diameter (PM(10)), particulate matter less than 2.5 microm in diameter (PM(2.5)), NO(2), SO(2), and mortality in 53,814 men in the U.S. trucking industry. METHODS exposures for PM(10), NO(2), and SO(2) at each residential address were assigned using models combining spatial smoothing and geographic covariates. PM(2.5) exposures in 2000 were assigned from the nearest available monitor. Single and multipollutant Cox proportional hazard models were used to examine the association of an interquartile range (IQR) change (6 microg/m(3) for PM(10), 4 microg/m(3) for PM(2.5), 4ppb for SO(2), and 8ppb for NO(2)) and the risk of all-cause and cause-specific mortality. MEASUREMENTS AND MAIN RESULTS an IQR change in ambient residential exposures to PM(10) was associated with a 4.3% (95% confidence interval [CI], 1.1-7.7%) increased risk of all-cause mortality. The increase for an IQR change in SO(2) was 6.9% (95% CI, 2.3-11.6%), for NO(2) was 8.2% (95% CI, 4.5-12.1%), and for PM(2.5) was 3.9% (95% CI, 1.0-6.9%). Elevated associations with cause-specific mortality (lung cancer, cardiovascular and respiratory disease) were observed for PM(2.5), SO(2), and NO(2), but not PM(10). None of the pollutants were confounded by occupational exposures. In multipollutant models, overall, the associations were attenuated, most strongly for PM(10). In sensitivity analyses excluding long-haul drivers, who spend days away from home, larger hazard ratios were observed. CONCLUSIONS in this population of men, residential ambient air pollution exposures were associated with mortality.