Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors to Adult Male Sexual Behavior in the Rat Deconstructing Early Life Experiences : Distinguishing the Contributions of Prenatal and Postnatal

In rodents, a pup’s experiences in utero and during postnatal development shape its sexual behavior as an adult and how it is perceived by potential mates. We show that the male rat’s sexuality is primarily influenced by the postnatal sex ratio of its litter, but not by the litter’s prenatal intrauterine sex ratio or the behavior of its mother. Pups from litters with differing prenatal sex ratios were divided into litters with differing postnatal sex ratios. We found that males raised in a female-biased litter exhibited less mounting than males raised in either a male-biased litter or one with an equal sex ratio, and were less attractive to sexually receptive females, eliciting fewer soliciting behaviors, such as hop-darts, and fewer lordosis behaviors. However, the number of intromissions and ejaculations did not differ across groups, which suggests that males from female-biased litters mate as efficiently as males raised in other sex ratios, but do not require as many mounts to do so. The reported differences in sexual behavior did not vary with the quality of maternal behavior or with sexual experience in adulthood.
Combining Acoustic and Pragmatic Features to Predict Recognition Performance in Spoken Dialogue Systems

We use machine learners trained on a combination of acoustic confidence and pragmatic plausibility features computed from dialogue context to predict the accuracy of incoming n-best recognition hypotheses to a spoken dialogue system. Our best results show a 25% weighted f-score improvement over a baseline system that implements a "grammar-switching" approach to context-sensitive speech recognition.
Interactive control of humanoid navigation

We present a method for interactively guiding the navigation of a humanoid robot through complex terrain via an intuitive path-drawing interface. In contrast to full autonomy or direct teleoperation of the robot, the user suggests an overall global navigation route by “drawing” a path onto the environment while the robot is walking. The path is used by a footstep planner that searches online for a sequence of suitable footstep locations that follow the indicated path as closely as possible while respecting the robot dynamics and overall navigation safety. In this way, the planner provides the robot partial autonomy in selecting precise footstep sequences while the human operator retains high-level control of the global navigation route. We present experimental results of the complete system on the biped humanoid HRP-2 navigating on and around various platforms, chairs, and stairs. We use an augmented reality system so that interactively drawing paths on the world is intuitive and natural.
Improved lower bounds for embeddings into L1

We simplify and improve upon recent lower bounds on the minimum distortion of embedding certain finite metric spaces into <i>l</i><inf>1</inf>. In particular, we show that for infinitely many values of <i>n</i> there are <i>n</i>-point metric spaces of negative type that require a distortion of Ω(log log <i>n</i>) for such an embedding, implying the same lower bound on the integrality gap of a well-known SDP relaxation for SPARSEST-CUT. This result builds upon and improves the recent lower bound of (log log <i>n</i>)<sup>1/6---o(1)</sup> due to Khot and Vishnoi [STOC 2005]. We also show that embedding the edit distance on {O, 1}<sup><i>n</i></sup> into <i>L<inf>1</inf></i> requires a distortion of Ω(log <i>n</i>). This result simplifies and improves a very recent lower bound due to Khot and Naor [FOCS 2005].
Isolation, Identification, and Pathogenicity of Neospora caninum China Yanbian strain

Background The aim of the study was to provide a point of reference to study the Neospora caninum infections in China. Methods Genome DNA was extracted from the brains of aborted fetuses and specific PCR was performed with N. caninum Nc5-targeted specific primers. Fetal bovine brain tissues were homogenized and continuously cultured in Vero cells with double antibodies. The medium was replaced at 2-d intervals and the state of cells was observed. Results A 608 bp Nc5 gene band was detected by PCR amplification. After sequencing, the sequence of the sample shared 99.5% homology with GenBank (AF061249). Brain homogenates were continuously cultured in Vero cells for 34 d and N. caninum was found. The results of IFAT and Nc5 gene-based PCR detection were N. caninum-positive, and the parasite was tentatively named N. caninum China Yanbian strain. BABL/c mice were inoculated with the separated parasites and showed clinical symptoms of ataxia and limb paralysis after 12 d. Only 3 mice survived. The blood of dying mice and the hearts, livers, spleens, lungs, kidneys, and brains of dead mice were collected aseptically. The Nc5 gene-based PCR showed that N. caninum may exist in brains, livers, and spleen. Based on immunohistochemical observations, we showed that N. caninum tachyzoites existed in the brains and livers. Conclusion We have successfully isolated bovine-specific N. caninum strain from brain tissues of aborted cattle in the China Yanbian region. This isolated strain has a strong infectious ability towards BABL/c mice.
Genome-Wide Association Study of Hepatocellular Carcinoma in Southern Chinese Patients with Chronic Hepatitis B Virus Infection

One of the most relevant risk factors for hepatocellular carcinoma (HCC) development is chronic hepatitis B virus (HBV) infection, but only a fraction of chronic HBV carriers develop HCC, indicating that complex interactions among viral, environmental and genetic factors lead to HCC in HBV-infected patients. So far, host genetic factors have incompletely been characterized. Therefore, we performed a genome-wide association (GWA) study in a Southern Chinese cohort consisting of 95 HBV-infected HCC patients (cases) and 97 HBV-infected patients without HCC (controls) using the Illumina Human610-Quad BeadChips. The top single nucleotide polymorphisms (SNPs) were then validated in an independent cohort of 500 cases and 728 controls. 4 SNPs (rs12682266, rs7821974, rs2275959, rs1573266) at chromosome 8p12 showed consistent association in both the GWA and replication phases (ORcombined = 1.31–1.39; pcombined = 2.71×10−5–5.19×10−4; PARcombined = 26–31%). We found a 2.3-kb expressed sequence tag (EST) in the region using in-silico data mining and verified the existence of the full-length EST experimentally. The expression level of the EST was significantly reduced in human HCC tumors in comparison to the corresponding non-tumorous liver tissues (P<0.001). Results from sequence analysis and in-vitro protein translation study suggest that the transcript might function as a long non-coding RNA. In summary, our study suggests that variations at chromosome 8p12 may promote HCC in patients with HBV. Further functional studies of this region may help understand HBV-associated hepatocarcinogenesis.
ENDOSCOPIC ENDONASAL PITUITARY TRANSPOSITION FOR A TRANSDORSUM SELLAE APPROACH TO THE INTERPEDUNCULAR CISTERN

OBJECTIVE The interpeduncular cistern, including the retroinfundibular area, is one of the most challenging regions to approach surgically. The pituitary gland and the infundibulum guard the region when an endonasal route is undertaken. Superior transposition of the pituitary gland and infundibulum is described as a functional means to access this complex region through a fully endoscopic, completely transnasal route. METHODs Ten consecutive patients in whom a pituitary transposition was performed during an expanded endonasal approach at the University of Pittsburgh Medical Center for resection of retroinfundibular lesions were reviewed. The series consisted of seven men and three women with a mean age of 44.4 years. Pathology consisted of four craniopharyngiomas, four chordomas, and two petroclival meningiomas. RESULTS Five patients (50%) underwent total resection of the tumor, three patients (30%) underwent near total resection (>95% removal), and two patients (20%) had partial resection of petroclival meningiomas with the goal of optic apparatus decompression. All four patients with visual deficits recovered their vision completely. There was no neurological deterioration. Eight patients had normal pituitary function preoperatively, seven of whom (87.5%) had confirmed function preservation postoperatively, with one of these patients experiencing transient diabetes insipidus. The remaining patient with a hypothalamic craniopharyngioma underwent complete resection with obligatory panhypopituitarism and diabetes insipidus. CONCLUSION Endoscopic endonasal transposition of the pituitary gland and its stalk can provide a valuable corridor to the retroinfundibular space and interpeduncular cistern with pituitary function preservation in the majority of patients. This approach should only be pursued once significant experience with endoscopic endonasal approaches has been acquired.
The effects of Class I and II sized bovids on macrofracture formation and tool displacement: Results of a trampling experiment in a southern African Stone Age context

Abstract In this paper we follow from previous experiments that assessed the formation of macrofractures on hunting weapons and trampled tools, and present the results of a new trampling experiment. This new experiment examined the relationship between small bovid trampling and the formation of macrofracture types on replicated stone and bone tools. We also recorded the resulting displacement of the tools in order to assess the relationship between tool morphology and displacement. Three tool types with dimensions similar to southern African archaeological tools were used. The results suggest that small frequencies of certain impact macrofractures occur on tools subject to trampling forces. These frequencies are, however, lower than those generally recorded during hunting experiments. Tool morphologies and fracture combinations are also shown to be important variables in macrofracture analyses. These results contribute to a growing body of experimental data dealing with the relationship between postdepositional processes and macrofracture formation on artifacts.
On Modeling Conformance for Flexible Transformation over Data Models

Many useful and commonly used data models exist for structured information. Such models often use only a limited number of basic structures to represent information such as sets, bags, lists, attribute-value pairs, and scalars. They differ, however, in whether or not they permit the specification of schema (or DTD or template), whether they permit more than one schema, and whether they require schema. Some even allow multiple levels of schema-instance conformance (e.g., RDF and Topic Maps) where the type of an instance is an instance, and so on. Support for transforming between such varying representation schemes remains a significant challenge. We extend our earlier work on generic representation and transformation of model-based information by introducing a richer metamodel and abstract framework for representation. We also introduce several steps toward our vision of high-level transformations where complex mapping rules are defined using transformation patterns and by exploiting inherent constraints.
Indications for Spine Surgery: Validation of an Administrative Coding Algorithm to Classify Degenerative Diagnoses

Study Design. Retrospective analysis of Medicare claims linked to a multicenter clinical trial. Objective. The Spine Patient Outcomes Research Trial (SPORT) provided a unique opportunity to examine the validity of a claims-based algorithm for grouping patients by surgical indication. SPORT enrolled patients for lumbar disc herniation, spinal stenosis, and degenerative spondylolisthesis. We compared the surgical indication derived from Medicare claims with that provided by SPORT surgeons, the “gold standard. ” Summary of Background Data. Administrative data are frequently used to report procedure rates, surgical safety outcomes, and costs in the management of spinal surgery. However, the accuracy of using diagnosis codes to classify patients by surgical indication has not been examined. Methods. Medicare claims were link to beneficiaries enrolled in SPORT. The sensitivity and specificity of 3 claims-based approaches to group patients on the basis of surgical indications were examined: (1) using the first listed diagnosis; (2) using all diagnoses independently; and (3) using a diagnosis hierarchy on the basis of the support for fusion surgery. Results. Medicare claims were obtained from 376 SPORT participants, including 21 with disc herniation, 183 with spinal stenosis, and 172 with degenerative spondylolisthesis. The hierarchical coding algorithm was the most accurate approach for classifying patients by surgical indication, with sensitivities of 76.2%, 88.1%, and 84.3% for disc herniation, spinal stenosis, and degenerative spondylolisthesis cohorts, respectively. The specificity was 98.3% for disc herniation, 83.2% for spinal stenosis, and 90.7% for degenerative spondylolisthesis. Misclassifications were primarily due to codes attributing more complex pathology to the case. Conclusion. Standardized approaches for using claims data to group patients accurately by surgical indications have widespread interest. We found that a hierarchical coding approach correctly classified more than 90% of spine patients into their respective SPORT cohorts. Therefore, claims data seem to be a reasonably valid approach to classifying patients by surgical indication. Level of Evidence: 3
Association Between Hospital and Surgeon Procedure Volume and Outcomes of Total Hip Replacement in the United States Medicare Population*

Background: The mortality and complication rates of many surgical procedures are inversely related to hospital procedure volume. The objective of this study was to determine whether the volumes of primary and revision total hip replacements performed at hospitals and by surgeons are associated with rates of mortality and complications. Methods: We analyzed claims data of Medicare recipients who underwent elective primary total hip replacement (58,521 procedures) or revision total hip replacement (12,956 procedures) between July 1995 and June 1996. We assessed the relationship between surgeon and hospital procedure volume and mortality, dislocation, deep infection, and pulmonary embolus in the first ninety days postoperatively. Analyses were adjusted for age, gender, arthritis diagnosis, comorbid conditions, and income. Analyses of hospital volume were adjusted for surgeon volume, and analyses of surgeon volume were adjusted for hospital volume. Results: Twelve percent of all primary total hip replacements and 49% of all revisions were performed in centers in which ten or fewer of these procedures were carried out in the Medicare population annually. In addition, 52% of the primary total hip replacements and 77% of the revisions were performed by surgeons who carried out ten or fewer of these procedures annually. Patients treated with primary total hip replacement in hospitals in which more than 100 of the procedures were performed per year had a lower risk of death than those treated with primary replacement in hospitals in which ten or fewer procedures were performed per year (mortality rate, 0.7% compared with 1.3%; adjusted odds ratio, 0.58; 95% confidence interval, 0.38, 0.89). Patients treated with primary total hip replacement by surgeons who performed more than fifty of those procedures in Medicare beneficiaries per year had a lower risk of dislocation than those who were treated by surgeons who performed five or fewer of the procedures per year (dislocation rate, 1.5% compared with 4.2%; adjusted odds ratio, 0.49; 95% confidence interval, 0.34, 0.69). Patients who had revision total hip replacement done by surgeons who performed more than ten such procedures per year had a lower rate of mortality than patients who were treated by surgeons who performed three or fewer of the procedures per year (mortality rate, 1.5% compared with 3.1%; adjusted odds ratio, 0.65; 95% confidence interval, 0.44, 0.96). Conclusions: Patients treated at hospitals and by surgeons with higher annual caseloads of primary and revision total hip replacement had lower rates of mortality and of selected complications. These analyses of Medicare claims are limited by a lack of key clinical information such as operative details and preoperative functional status.
Dynamic Testing of ADC: A Review

Analog to digital converters are Mixed signal devices. With the increasing popularity of these devices , it is important to get more faster and accurate device. Along with design, testing of ADC plays major role . Static and Dynamic methods are available for ADC testing. Ideal ADC itself has quantization error. A NonIdeal ADC consists many other errors like offset error, Gain error, DNL, INL,ENOB,SNR,THD,SINAD etc. In this paper various methods of dynamic testing of ADC are discussed.
Temporally tuned neuronal differentiation supports the functional remodeling of a neuronal network in Drosophila

During insect metamorphosis, neuronal networks undergo extensive remodeling by restructuring their connectivity and recruiting newborn neurons from postembryonic lineages. The neuronal network that directs the essential behavior, ecdysis, generates a distinct behavioral sequence at each developmental transition. Larval ecdysis replaces the cuticle between larval stages, and pupal ecdysis externalizes and expands the head and appendages to their adult position. However, the network changes that support these differences are unknown. Crustacean cardioactive peptide (CCAP) neurons and the peptide hormones they secrete are critical for ecdysis; their targeted ablation alters larval ecdysis progression and results in a failure of pupal ecdysis. In this study, we demonstrate that the CCAP neuron network is remodeled immediately before pupal ecdysis by the emergence of 12 late CCAP neurons. All 12 are CCAP efferents that exit the central nervous system. Importantly, these late CCAP neurons were found to be entirely sufficient for wild-type pupal ecdysis, even after targeted ablation of all other 42 CCAP neurons. Our evidence indicates that late CCAP neurons are derived from early, likely embryonic, lineages. However, they do not differentiate to express their peptide hormone battery, nor do they project an axon via lateral nerve trunks until pupariation, both of which are believed to be critical for the function of CCAP efferent neurons in ecdysis. Further analysis implicated ecdysone signaling via ecdysone receptors A/B1 and the nuclear receptor ftz-f1 as the differentiation trigger. These results demonstrate the utility of temporally tuned neuronal differentiation as a hard-wired developmental mechanism to remodel a neuronal network to generate a scheduled change in behavior.
Can we select health professionals who provide safer care

In order to improve patient safety, health services are looking to other industries’ experiences and as a result are adopting a systems approach to learning from error, rather than simply focusing the blame on the individual. However, in health care the individual will remain an important contributor to safety and this paper looks at other literatures besides health to consider a number of individual characteristics and the role they might play in terms of work practices that affect patient safety. It considers the effects of a variety of personality profiles including sensation seeking, Type A, and those with high self esteem; looks at our ability to select for psychological wellbeing; and discusses the ways that psychometrics have been used in medicine to predict performance. It concludes that although rarely used, psychometrics has been shown to be useful in predicting some aspects of performance in medicine and suggests that this is an area well worth further study for the benefit of patient care. Nevertheless, we are a long way away from being able to select safer staff and should instead be developing this knowledge to enable us to recognise and address potential difficulties.
Tighter Linear and Semidefinite Relaxations for Max-Cut Based on the Lov[a-acute]sz--Schrijver Lift-and-Project Procedure

We study how the lift-and-project method introduced by Lovasz and Schrijver [SIAM J. Optim. , 1 (1991), pp. 166--190] applies to the cut polytope. We show that the cut polytope of a graph can be found in k iterations if there exist k edges whose contraction produces a graph with no K5-minor. Therefore, for a graph G with $n\ge 4$ nodes with stability number $\alpha(G)$, n-4 iterations suffice instead of the m (number of edges) iterations required in general and, under some assumption, $n-\alpha(G)-3$ iterations suffice. The exact number of needed iterations is determined for small $n\le 7$ by a detailed analysis of the new relaxations. If positive semidefiniteness is added to the construction, then one finds in one iteration a relaxation of the cut polytope which is tighter than its basic semidefinite relaxation and than another one introduced recently by Anjos and Wolkowicz [Discrete Appl. Math., to appear]. We also show how the Lovasz--Schrijver relaxations for the stable set polytope of G can be strengthened using the corresponding relaxations for the cut polytope of the graph $G^\nabla$ obtained from G by adding a node adjacent to all nodes of G.
Opposing Effects of Semantic Diversity in Lexical and Semantic Relatedness Decisions

Semantic ambiguity has often been divided into 2 forms: homonymy, referring to words with 2 unrelated interpretations (e.g., bark), and polysemy, referring to words associated with a number of varying but semantically linked uses (e.g., twist). Typically, polysemous words are thought of as having a fixed number of discrete definitions, or “senses,” with each use of the word corresponding to one of its senses. In this study, we investigated an alternative conception of polysemy, based on the idea that polysemous variation in meaning is a continuous, graded phenomenon that occurs as a function of contextual variation in word usage. We quantified this contextual variation using semantic diversity (SemD), a corpus-based measure of the degree to which a particular word is used in a diverse set of linguistic contexts. In line with other approaches to polysemy, we found a reaction time (RT) advantage for high SemD words in lexical decision, which occurred for words of both high and low imageability. When participants made semantic relatedness decisions to word pairs, however, responses were slower to high SemD pairs, irrespective of whether these were related or unrelated. Again, this result emerged irrespective of the imageability of the word. The latter result diverges from previous findings using homonyms, in which ambiguity effects have only been found for related word pairs. We argue that participants were slower to respond to high SemD words because their high contextual variability resulted in noisy, underspecified semantic representations that were more difficult to compare with one another. We demonstrated this principle in a connectionist computational model that was trained to activate distributed semantic representations from orthographic inputs. Greater variability in the orthography-to-semantic mappings of high SemD words resulted in a lower degree of similarity for related pairs of this type. At the same time, the representations of high SemD unrelated pairs were less distinct from one another. In addition, the model demonstrated more rapid semantic activation for high SemD words, thought to underpin the processing advantage in lexical decision. These results support the view that polysemous variation in word meaning can be conceptualized in terms of graded variation in distributed semantic representations.