Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel Therapeutic Strategies for Malignant Salivary Gland Tumors: Lessons Learned from Breast Cancer

Malignant salivary gland tumors (MSGTs) account for 2–6% of all head and neck cancers. Despite the rarity, MSGTs have been of great interest due to a wide variety of pathological features and high metastasis rates resulting in poor prognosis. Surgical resection followed by radiation therapy represents the main treatment of this malignancy. Adjuvant therapy is reserved for the management of local recurrence, no longer amenable to additional local therapy, and for metastasis. Based on the studies from other types of tumors, particularly breast cancer, the expression and function of sex steroid hormone receptors in cancer have been extensively studied and applied to diagnosis and treatment. Although a number of studies in MSGTs have been published, the rationale for hormone therapy is still controversial due to the disparate results and insufficient number of cases. However, some recent reports have demonstrated that certain salivary gland neoplasms are similar to breast cancer, not only in terms of the pathological features, but also at the molecular level. Here, we shed light on the biological similarity between MSGTs and certain types of breast cancer, and describe the potential use of hormone and additional therapies for MSGTs.
Follow-up Study of a Creativity Scale for the Adjective Check List

An earlier study (Smith & Schaefer, 1969) reported the empirical development of a 27-item Creativity Scale for the Adjective Check List (ACL; Gough & Heilbrun, 1965). In general, this Creativity Scale proved more successful in discriminating creative and control high school students in cross-validation samples than did the ACL personality scales. The purpose of the present study was to conduct a 5-yr. follow-up investigation of the ACL responses of the same Ss to determine if the discriminatoty power of the Creativity Scale is stable over time. The 800 Ss in the initial study were sent the ACL and another questionnaire to complete and return by mail. At the time of the current study, most Ss were either completing or had just completed their fourth year of college. A total of 390 Ss returned useable ACLs which represents a 48% return. The 390 Ss were comprised, in about equal numbers, from eight criterion groups: Creative Art-Writing-Boys, Control Art-Writing-Boys, Creative Math-Science-Boys, Control Math-Science-Boys, Creative ArtGirls, Control Art-Girls, Creative Writing-Girls, Control Writing-Girls. Within each criterion group the respondents and nonrespondencs were comparable on relevant background variables, i.e., age, educational level, academic achievement, and creativity test scores. A complete description of the criterion groups is found in Smith and Schaefer (1969), while details concerning the representativeness of the follow-up sample are contained in Schaefer (1972). In the present study, the range of mean ACL Creativity Scale scores across the four creative groups was 11.36 to 13.61 (highest possible score is 26 since one item of 27 has a negative weight); the range for the control Ss was 7.61 to 9.84. The t values for the respective criterion group comparisons were as follows: for Creative Art-Writing-Boys vs Control An-Writing-Boys 4.79 (P < ,001); for Creative Math-Science-Boys vs Control Math-Science-Boys 2.30 ( P < .05); for Creative ArtGirls vs Control Art-Girls 3.59 ( P < .001); for Creative Writing-Girls vs Control Writing-Girls 6.04 ( P < .001). Thus the results indicate that as creative students move from early to late adolescence they continue to report a distinctively creative selfconcept. This self-image is characterized by such adjectives as artistic, imaginative, original, progressive, quick, resourceful, sharp-witted, and spontaneous. Related to the constancy of this creative self-perception is the finding (see Schaefer, 1972) that the creative Ss report more creative achievements than controls during this time.
Grid Task Scheduling Based on Adaptive Ant Colony Algorithm

On the basis of former work, this paper presents an improved ant colony algorithm, namely adaptive ant colony algorithm for grid task scheduling. In the proposed algorithm, the value of evaporation rate p is adaptively changed and a minimum value pmin is assigned. Thereby, the evaporation rate p is under control and will never be reduced to 0. Comparing experimental results with the original algorithm show that the proposed algorithm is more efficient both in task scheduling efficiency and resource load.
Intravital Microscopic Evaluation of the Effects of a CXCR2 Antagonist in a Model of Liver Ischemia Reperfusion Injury in Mice

Background Ischemia–reperfusion (IR) is a major contributor to graft rejection after liver transplantation. During IR injury, an intense inflammatory process occurs in the liver. Neutrophils are considered central players in the events that lead to liver injury. CXC chemokines mediate hepatic inflammation following reperfusion. However, few studies have demonstrated in real-time the behavior of recruited neutrophils. We used confocal intravital microscopy (IVM) to image neutrophil migration in the liver and to analyze in real-time parameters of neutrophil recruitment in the inflamed tissue in animals treated or not with reparixin, an allosteric antagonist of CXCR1/2 receptors. Materials and methods WT and LysM-eGFP mice treated with reparixin or saline were subjected to 60 min of ischemia followed by different times of reperfusion. Mice received Sytox orange intravenously to show necrotic DNA in IVM. The effect of reparixin on parameters of local and systemic reperfusion-induced injury was also investigated. Results IR induced liver injury and inflammation, as evidenced by high levels of alanine aminotransferase and myeloperoxidase activity, chemokine and cytokine production, and histological outcome. Treatment with reparixin significantly decreased neutrophil influx. Moreover, reparixin effectively suppressed the increase in serum concentrations of TNF-α, IL-6, and CCL3, and the reperfusion-associated tissue damage. The number of neutrophils in the liver increased between 6 and 24 h of reperfusion, whereas the distance traveled, velocity, neutrophil size and shape, and cluster formation reached a maximum 6 h after reperfusion and then decreased gradually. In vivo imaging revealed that reparixin significantly decreased neutrophil infiltration and movement and displacement of recruited cells. Moreover, neutrophils had a smaller size and less elongated shape in treated mice. Conclusion Imaging of the liver by confocal IVM was successfully implemented to describe neutrophil behavior in vivo during liver injury by IR. Treatment with reparixin decreased not only the recruitment of neutrophils in tissues but also their activation state and capacity to migrate within the liver. CXCR1/2 antagonists may be a promising therapy for patients undergoing liver transplantation.
A document comparison approach using hybrid keyword and structured full text vocabulary searches

This paper proposes a systematic full text search on document using a combined keyword and structural similarity of documents under consideration. The approach operates in two steps. The first step uses a set of designated keywords to acquire potential desired documents by means of an open source tool. The second step builds a suffix tree of frequently used vocabulary to retrieve the most similar documents from the acquired documents. In so doing, variations on contextual matching of full text search can be mitigated, wherein the resulting performance turns out to be quite acceptable. The ultimate goal is to arrive at a platform independent full text search technique that can be realized. The benefits for this scheme are two folds. On the one hand, relevant document can be retrieved as close to the desired document as possible. On the other hand, suspect plagiarism can be identified to some extent, which is dependent on the effectiveness of the proposed approach with plenty of rooms for future improvement. The proposed work will eventually be put to real use for database retrieval in a small business enterprise.
sCD44 overexpression increases intraocular pressure and aqueous outflow resistance

Purpose CD44 plays major roles in multiple physiologic processes. The ectodomain concentration of the CD44 receptor, soluble CD44 (sCD44), is significantly increased in the aqueous humor of primary open-angle glaucoma (POAG). The purpose of this study was to determine if adenoviral constructs of CD44 and isolated 32-kDa sCD44 change intraocular pressure (IOP) in vivo and aqueous outflow resistance in vitro. Methods Adenoviral constructs of human standard CD44 (Ad-CD44S), soluble CD44 (Ad-sCD44), and empty viral cDNA were injected into the vitreous of BALB/cJ mice, followed by serial IOP measurements. Overexpression of CD44S and sCD44 was verified in vitro by enzyme-linked immunosorbent assay (ELISA) and western blot analysis. Anterior segments of porcine eyes were perfused with the isolated sCD44. sCD44-treated human trabecular meshwork (TM) cells and microdissected porcine TM were examined by confocal microscopy and Optiprep density gradient with western blot analysis to determine changes in lipid raft components. Results Intravitreous injection of adenoviral constructs with either Ad-CD44S or Ad-sCD44 vectors caused prolonged ocular hypertension in mice. Eight days after vector injection, Ad-CD44S significantly elevated IOP to 28.3±1.2 mmHg (mean±SEM, n=8; p<0.001); Ad-sCD44 increased IOP to 18.5±2.6 mmHg (n=8; p<0.01), whereas the IOP of uninjected eyes was 12.7±0.2 mmHg (n=16). The IOP elevation lasted more than 50 days. Topical administration of a γ-secretase inhibitor normalized Ad-sCD44-induced elevated IOP. sCD44 levels were significantly elevated in the aqueous humor of Ad-CD44S and Ad-sCD44 eyes versus contralateral uninjected eyes (p<0.01). Anterior segment perfusion of isolated 32-kDa sCD44 significantly decreased aqueous outflow rates. Co-administration of isolated sCD44 and CD44 neutralizing antibody or of γ-secretase inhibitor significantly enhanced flow rates. sCD44-treated human TM cells displayed cross-linked actin network formation. Optiprep density gradient and western blot analysis of human TM cells treated with sCD44 showed decreased annexin 2 expression and increased phosphorylated annexin 2 and caveolin 1 expression. Conclusions Our data suggest that sCD44 increases outflow resistance in vivo and in vitro. Viral overexpression of both CD44S and sCD44 is sufficient to cause ocular hypertension. Infusion of sCD44 in porcine anterior segment eyes significantly decreased flow rates. Notably, sCD44 enhanced cross-linked actin network formation. The elevated sCD44 levels seen in POAG aqueous humor may play an important causative role in POAG pathogenesis.
Eurofit test battery for the assessment of physical abilities and health fitness in children

The modern way of life has led to the fact that hypokinesia and obesity are not just a problem of adults but also the growing number of children. In the prevention and elimination of the problem focused physical activity, which is carried out within the framework of physical education plays an important role. To be able to assess the physical and health fitness of children, there is a need for their testing and the establishment of reference parameters. For this purpose, in Europe, is set aside Eurofit test battery (EUROFIT), consisting of simple and inexpensive tests that can be run in regular physical education classes or additional training, as well as medical centers. Besides their role in assessing the effectiveness of the curriculum of physical education, a modified version of EUROFIT can be used to monitor the physical and psychological status of children with disabilities, including children with mental disabilities. Eurofit test battery has its own place in areas related to analytics and diagnostics in training (identification and selection of talent, training control). Although primarily designed for testing children aged 6 to 18 years, can be successfully applied in older age groups.
Network Exchange Theory: Recent Developments and New Directions

The new millennium opens the third decade of work on network exchange theory. During two decades of continuous growth, the program has been tested as intensively and extensively as any in sociology. This article summarizes existing research and describes new directions. First, we describe basic network connections and recently discovered structural power conditions that sharply affect exchange ratios. Then we show how game theory enhances understanding of collective action in exchange networks. Two new research programs link network exchange theory to status characteristics theory: the first demonstrates that power produces status, and the second shows how status value produces power. Finally, we discuss how questions about network dynamics, complexity, and legitimation define paths for future theory growth.
Endometrial Receptivity: A Revisit to Functional Genomics Studies on Human Endometrium and Creation of HGEx-ERdb

Background Endometrium acquires structural and functional competence for embryo implantation only during the receptive phase of menstrual cycle in fertile women. Sizeable data are available to indicate that this ability is acquired by modulation in the expression of several genes/gene products. However, there exists little consensus on the identity, number of expressed/not-detected genes and their pattern of expression (up or down regulation). Methods Literature search was carried out to retrieve the data on endometrial expression of genes/proteins in various conditions. Data were compiled to generate a comprehensive database, Human Gene Expression Endometrial Receptivity database (HGEx-ERdb). The database was used to identify the Receptivity Associated Genes (RAGs) which display the similar pattern of expression across different investigations. Transcript levels of select RAGs encoding cell adhesion proteins were compared between two human endometrial epithelial cell lines; RL95-2 and HEC-1-A by quantitative real time polymerase chain reaction (q-RT-PCR). Further select RAGs were investigated for their expression in pre-receptive (n = 4) and receptive phase (n = 4) human endometrial tissues by immunohistochemical studies. JAr spheroid attachment assays were carried out to assess the functional significance of two RAGs. Results HGEx-ERdb (http://resource.ibab.ac.in/HGEx-ERdb/) helped identification of 179 RAGs, of which 151 genes were consistently expressed and upregulated and 28 consistently not-detected and downregulated in receptive phase as compared to pre-receptive phase. q-RT-PCR confirmed significantly higher (p<0.005) expression of Thrombospondin1 (THBS1), CD36 and Mucin 16 transcripts, in RL95-2 as compared to HEC-1-A. Further, the pretreatment with antibodies against CD36 and COMP led to a reduction in the percentage of JAr spheroids attached to RL95-2. Immunohistochemical studies demonstrated significantly higher (p<0.05) expression of endometrial THBS1, Cartilage Oligomeric Matrix Protein (COMP) and CD36 in the receptive phase as compared to pre-receptive phase human endometrial tissues. Conclusion HGEx-ERdb is a catalogue of 19,285 genes, reported for their expression in human endometrium. Further 179 genes were identified as the RAGs. Expression analysis of some RAGs validated the utility of approach employed in creation of HGEx-ERdb. Studies aimed towards defining the specific functions of RAGs and their potential networks may yield relevant information about the major ‘nodes’ which regulate endometrial receptivity.
Construction of a Screening Test for Gustatory Function in Four Basic Tastes

The purpose of this study was to determine the effectiveness of a screening test for gustatory function in four basic tastes using a whole-mouth test with one concentration of a taste solution together with the Visual Analogue Scale (VAS) score. In experiment1, 84 healthy subjects were recruited to determine the concentrations used for whole-mouth gustatory tests in this study. The subjective intensity of taste was scored by the VAS, to be evaluated as the sensitivity of gestation (hereinafter known as gustatory VAS score). In experiment2, four subjects were randomly pick up from the subjects of experiment 1. The diurnal variation and day-to-day variation of the gustatory threshold value of four basic tastes were investigated. In experiment3, the results from a screening test for gustatory function in four basic tastes using each of the concentration obtained in experiment 1 were investigated. The results obtained were as follows: 1. The lowest concentration that could be identified by all subjects was 0.075 M for sucrose, 0.2 M for sodium chloride, 2.0×10 M for citric acid, and 7.5×10 M for quinine hydrochloride. 2. The following observations were made using the screening test for gustatory function developed in this study, Seven of the 25 subjects (28%) were diagnosed as taste decrease. Within the limitation of research design, these results demonstrate that gustatory function in four basic tastes could be assessed using a whole-mouth test with one specific concentration of a taste solution combined with the VAS 顎機能誌20:115-129,2014 116 4基本味における味覚機能のスクリーニング検査法の構築 117 score. Therefore, this method could be used as a screening test for gustatory function in four basic tastes. 抄録 本研究の目的は,味覚機能検査の全口腔法と Visual Analogue Scale(以下,VASと略す)を併用し, 全ての被験者が認知し得る最低濃度を基本味ごとに1種類選定することにより,1味質につき1種類のみ の検査液を応用した,4基本味における味覚機能スクリーニング検査法を構築することである. 実験1では,被験者として健常有歯顎者84名を選択し,すべての被験者が認知し得る最低濃度を基本 味ごとに1種類選定するための検査濃度設定について検討を行った. また,その時に感じた味の強さに関 しては VASによりスコア化し(以下,味覚 VAS値と略す),平均値を算出した. 実験2では,被験者として実験1で選択した被験者の中から4名を無作為に抽出し,4基本味における 日内変動および日間変動について検討を行った. 実験3では,被験者として健常有歯顎者25名を選択し,実験1で求めた濃度の検査液を用いて味覚機 能検査を実施し,本研究の味覚機能スクリーニング検査法としての可能性について検討を行った. その 結果,全員が味を認識できた最低濃度は,甘味0.075 M,塩味0.2 M,酸味2.0×10 M,苦味7.5×10 M となり,すべての被験者が認知し得る最低濃度を基本味ごとに1種類選定し得ることが示された. また, 本研究の味覚機能スクリーニング検査法を用いることにより,被験者25人中7人(28%)に味覚障害が 認められた. 以上より,全口腔法に VASを併用した本法が若年者における味覚機能のスクリーニング検 査法として有用となる可能性が示唆された. キーワード:4基本味,全口腔法,味覚 VAS値,スクリーニング検査法
Protective Effect of S,β-Aminoethylisothiuronium• Br• HBr and Related Compounds Against X-Radiation Death in Mice.∗

Conclusions (a) Replacement of the sulfhydryl group of β-mercaptoethylamine with the isothiuronium group yields a compound (AET) with increased protective activity and greater chemical stability, (b) A free amino group beta or gamma to the sulfhydryl or isothiuronium group is necessary for protective activity, (c) In the aminoisothiuronium series, the carbon chain can be lengthened by one carbon atom without the loss of protective activity, (d) S,β-aminoethylisothiuronium• Br• HBr provides effective protection against radiation injury at dose levels considerably less than the dose required to produce acute toxic effects.
Helping Children with Asthma by Repairing Maternal-infant Bonding Problems

Abstract Studies about the psychology of childhood asthma have revealed that parenting difficulties are related to the development of asthma in some children. Disruptions in maternal-infant bonding are highly correlated with pediatric asthma and are presented as a cause for these parenting problems. Bonding problems are known to be caused most often by physical separation at birth or by some recent trauma in the mother's life. By using hypnosis to remove the pain of the separation or trauma in the mother, and by creating a new birth history in her imagination, some children's asthmatic symptoms have been shown to remit or greatly improve. The hypnotic method for this treatment is described.
A molecular test to identify resistance alleles at the amplified esterase locus in the mosquito Culex pipiens

A new PCR/RFLP method is presented to identify all described alleles involved in resistance at the Ester locus in the mosquito Culex pipiens. The efficiency of this method as well as its advantages compared with the traditional identification technique (starch gel electrophoresis) have been tested in four natural samples from France, Tunisia and California. This simple and fast molecular test is a very convenient tool for studies in field populations and laboratory strains. # 2000 Society of Chemical Industry
Wavelets and signal processing

A simple, nonrigorous, synthetic view of wavelet theory is presented for both review and tutorial purposes. The discussion includes nonstationary signal analysis, scale versus frequency, wavelet analysis and synthesis, scalograms, wavelet frames and orthonormal bases, the discrete-time case, and applications of wavelets in signal processing. The main definitions and properties of wavelet transforms are covered, and connections among the various fields where results have been developed are shown. <<ETX>>
Developing an Ear Prosthesis Fabricated in Polyvinylidene Fluoride by a 3D Printer with Sensory Intrinsic Properties of Pressure and Temperature

An ear prosthesis was designed in 3D computer graphics software and fabricated using a 3D printing process of polyvinylidene fluoride (PVDF) for use as a hearing aid. In addition, the prosthesis response to pressure and temperature was observed. Pyroelectric and piezoelectric properties of this ear prosthesis were investigated using an astable multivibrator circuit, as changes in PVDF permittivity were observed according to variations of pressure and temperature. The results show that this prosthesis is reliable for use under different conditions of pressure (0 Pa to 16,350 Pa) and temperature (2 °C to 90 °C). The experimental results show an almost linear and inversely proportional behavior between the stimuli of pressure and temperature with the frequency response. This 3D-printed ear prosthesis is a promising tool and has a great potentiality in the biomedical engineering field because of its ability to generate an electrical potential proportional to pressure and temperature, and it is the first time that such a device has been processed by the additive manufacturing process (3D printing). More work needs to be carried out to improve the performance, such as electrical stimulation of the nervous system, thereby extending the purpose of a prosthesis to the area of sensory perception.
Identification and Characterization of Pheromone Receptors and Interplay between Receptors and Pheromone Binding Proteins in the Diamondback Moth, Plutella xyllostella

Moths depend on olfactory cues such as sex pheromones to find and recognize mating partners. Pheromone receptors (PRs) and Pheromone binding proteins (PBPs) are thought to be associated with olfactory signal transduction of pheromonal compounds in peripheral olfactory reception. Here six candidate pheromone receptor genes in the diamondback moth, Plutella xyllostella were identified and cloned. All of the six candidate PR genes display male-biased expression, which is a typical characteristic of pheromone receptors. In the Xenopus-based functional study and in situ hybridization, PxylOR4 is defined as another pheromone receptor in addition to the previously characterized PxylOR1. In the study of interaction between PRs and PBPs, PxylPBPs could increase the sensitivity of the complex expressing oocyte cells to the ligand pheromone component while decreasing the sensitivity to pheromone analogs. We deduce that activating pheromone receptors in olfactory receptor neurons requires some role of PBPs to pheromone/PBP complex. If the chemical signal is not the pheromone component, but instead, a pheromone analog with a similar structure, the complex would have a decreased ability to activate downstream pheromone receptors.