Miracle-dz/UniFAR-FTUs huggingface dataset:
An e-healthcare sensor network load-balancing scheme using SDN-SFC

The constant rapid growth and development of modern medical technology has resulted in an ever-growing demand for higher quality health monitoring systems. This is especially true for the development of the Internet of Things: as the Internet of Things becomes more ubiquitous in dally life, so does the possibility of, and demand for, the ability to remotely monitor the health of patients at anytime, anywhere, using a wide variety of biometrie information. Thus e-Healthcare has become a significant trend in the medical field. In addition to monitoring a patient's health remotely, data can also be relayed to doctors or hospitals in real-time, in order to assist in correct medical decision-making. Hospitals have begun to implement this technology, and patients therefore have immediate access to required diagnoses and care. However, the use of a large number of remote medical sensors requires significant bandwidth, especially when relaying real-time information. Hospital networks thus become susceptible to problems arising from network congestion. This study proposes a load-balancing mechanism based on SDN-SFC for the optimization of hospital remote-monitoring network planning, which simultaneously eliminates the need for large amounts of hardware.
Visualization-based communities discovering in commuting networks : a case study

The division of a national territory is a mandatory process to analyze socio-economic dynamics. Com- muting is then an important dimension to build such classification and weighted network analysis is adapted to study this phenomena. We present in this paper a procedure to identify groups of cities where commuters flow are relatively dense through a case study: a huge network which represents commuting in France (based on the 1999 national census). Our approach is based on a common technique improved by visual tools: highlight dense areas using a strength metric and extract clusters using the variation of a quality measure function.
The Stress signal extracellular ATP modulates antiflagellin immune responses in intestinal epithelial cells

Background: Although intestinal epithelial cells (IECs) are continually exposed to commensal microbes, under healthy conditions they contribute to intestinal homeostasis while keeping inflammatory responses in check. In response to invading pathogens, however, IECs respond vigorously by producing inflammatory mediators. To better understand the signals that regulate the inflammatory responses of IECs, we investigated whether the danger signal ATP (which is released from injured cells) could alter responses to bacterial products. Methods: We measured chemokine production from Caco‐2 cells stimulated with the Toll‐like receptor 5 agonist flagellin with or without ATP. ATP increased flagellin‐induced IL‐8 secretion but reduced CCL20 secretion via distinct signaling pathways. Results: ATP‐enhanced IL‐8 production was only partly blocked by the P2 receptor antagonist suramin and required activation of NF‐&kgr;B while ATP‐mediated reduction of CCL20 was completely blocked by suramin and required activation of ERK1/2. The effects of ATP on both chemokines required extracellular calcium but not phospholipase C, implicating P2X receptor involvement. To investigate how ATP alters IEC responses to bacterial products in vivo, mice receiving dextran sodium sulfate were given intrarectal flagellin with or without ATP. Addition of ATP to flagellin caused greater weight loss and increased antiflagellin antibody titers, as well as decreased colonic interferon gamma (IFN‐&ggr;) and higher antiflagellin IgG1/IgG2 ratios, which indicate decreased Th1 polarization. Conclusions: Together, these data indicate that stress, in the form of extracellular ATP, reshapes both the inflammatory response of flagellin‐stimulated IECs and downstream adaptive immunity, representing a possible strategy by which these cells differentiate between commensal and pathogenic bacteria. (Inflamm Bowel Dis 2011;)
Delayed sample arrival at the laboratory does not lead to more false negatives in the Danish population screening for colorectal cancer

Abstract In Denmark, biennial population screening for colorectal cancer was introduced in 2014 for all aged 50–74 years. Five laboratories representative for the regional division of Denmark perform the immunochemical testing of faecal occult blood in the screening samples (iFOBT, OC-Sensor (Eiken Chemical, cut-off 100 µg/L)). In July 2016, a new agreement on the public post-delivery entailed an increased lag time (five days) from the screening participant drops the screening sample into a mail-box until sample arrival at the laboratories. Previous work had reported that a lag time above five days led to more false negative iFOBT tests. We investigated if this was true also under Danish conditions. We performed two stability tests; one with sample storage at 30 °C for 14 days (N = 60), and another with sample storage at room temperature for 13 days (N = 10). We extracted data from our laboratory information system (LABKA) on all iFOBT tests performed in the entire Central Denmark Region (N = 104,328 patients) during the last six months for each calendar year 2014–16. For each year, we computed the distribution of iFOBT tests below and above cut-off. Our stability tests showed no positive samples switching to false negative after storage; however, some negative samples turned false positive, especially at 30 °C. The data showed no change in the distribution of iFOBT tests below and above cut-off after July 2016. We found no evidence that an enhanced lag time increased the number of false negative iFOBT tests in the Danish screening program for colorectal cancer.
Relative differences in aryl hydrocarbon receptor‐mediated response for 18 polybrominated and mixed halogenated dibenzo‐P‐dioxins and ‐furans in cell lines from four different species

As a consequence of ubiquitous use of brominated organic chemicals, there is a concern for persistent or increasing environmental levels of polybrominated dibenzo‐p‐dioxins/furans (PBDD/Fs) and mixed polychlorinated and polybrominated di‐benzo‐p‐dioxins/furans (PXDD/Fs). Hence, there is a need to broaden the toxicological and environmental knowledge about these compounds, as a basis for risk assessment. In the study presented here, the relative potencies (REPs) for 18 PBDD/F and PXDD/F congeners were determined in four dioxin‐specific bioassays from different species: dioxin receptor chemically activated luciferase expression assay (DR‐CALUX, rat hepatoma cells), TV101L (human hepatoma cells), and GPC.2D (guinea pig adenoma cells), as well as ethoxyresorufin‐O‐deethylase induction in the fish cell line RTL‐W1 (rainbow trout liver cells). The bioassay specific REP factors presented here enable the assessment of the contribution from PBDD/Fs and PXDD/Fs to total 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) equivalents (TEQs: toxic equivalents), using bioassay analysis. The PBDD/Fs were found to be equally potent as their chlorinated analogues in the three mammalian assays, whereas the PXDD/Fs showed relatively higher potencies. Of special concern were the 2,3,7,8‐substituted penta‐ and tetrahalogenated congeners, for which mean REPs were >1. The 2‐B‐1,3,7,8‐CDD (2‐bromo‐1,3,7,8‐tetrachlorodibenzo‐p‐dioxin) was up to three times more potent than TCDD in individual experiments (on weight basis). The RTL‐W1 was less sensitive to the tested compounds with overall 10‐fold lower REPs than the mammalian cell lines. Although the REP factors exhibited species‐specific differences, overall resembling rank orders of dioxin‐like potency were obtained.
An efficient solution to the socialist millionaires' problem

We present a two-round protocol to solve the socialist millionaire problem based on the homomorphic property of the Goldwasser-Micali (GM) cryptosystem. We require the proposed protocol to be secure against active and passive attacks. However, homomorphic encryption schemes are malleable by design [14][1]. To tackle this problem we apply an authenticated encryption scheme, called Encrypt-then-MAC, to our protocol [3]. We analyze the security of the proposed protocol, and we show that an active adversary, who has access to the ciphertext on the communication channel and the decryption oracle, cannot forge another ciphertext which leads him to guess the plaintext (IND-CCA2 security). Moreover, the active adversary cannot modify the ciphertext which leads to a desired modification of the plaintext to affect the outcome of the protocol (NM-CCA2 security). Note that our solution can be applied to other problems which are solvable with an exclusive- or homomorphic property.
Effects of fenugreek (Trigonella foenum-graecum L.) seed powder on growth performance, visceral organ Weight, serum cholesterol levels and the Nitrogen retention of broiler or chicken

Fenugreek (Trigonella foenum-graecum L.) is a medicinal plant having a range of therapeutic, anti-microbial and growth promoting effects. Objective of this study was to evaluate the effects of fenugreek seed powder on growth performance, visceral organ weight, serum cholesterol levels and the nitrogen (N) retention of broiler chicken. In a Complete Randomized Design with six replicates, 108 chicks in 36 pens received one of the six experimental diets containing either 0, 1, 2, 3, 4, 5% fenugreek powder from day 21-38. The weight gain of the birds that were fed with 4 and 5% fenugreek was significantly lower (p 0.05) altered by dietary fenugreek. It was concluded that 1 % dietary fenugreek has some growth promoting effects in broiler chicken. Tropical Agricultural Research Vol.24 (3): 289-295 (2013)
The moderating effect of employees' personality on the relationship between charismatic leadership and organizational citizenship behavior: Analysis of the high-tech firms in Southern Taiwan

This study analyzed the impact of employees' personality on the relationship between charismatic leadership and organizational citizenship behavior (OCB). This research revised the measuring scales constructed by previous scholars. Survey data were collected from 375 supervisor-subordinate dyads of the high-tech firms in Southern Taiwan Science Park (STSP), and 81 dyads of questionnaires were effectively returned. Reliability analysis, correlation analysis, and hierarchical regression analysis were adopted to test the hypotheses of this research. The results showed that charismatic leadership had a significant positive effect on OCB. Besides, employees' personality traits had moderating effect on the relationship between charismatic leadership and OCB. Some discussions on the conclusion and implications were made, and this research also offers several suggestions on management practices and directions of future research to academia and practice.
Use of a Real‐Time Three‐Dimensional Magnetic Navigation System for Radiofrequency Ablation of Accessory Pathways

Using conventional technology, accessory pathway abiation often requires prolonged exposure of the team and patient to ionizing radiation. Further, although the primary success rate (approximately 90%) and the rate of recurrence (approximately 10%) are acceptable, there is room for improvement. Finally, inadvertent ablation of the compact node and A V/His‐Purkinje system still occurs particularly with septal accessory pathways. The Biosense CAHTO Nonfluoroscopic Mapping and Navigation System (CARTO® System) when used to locate the accessory pathway and guide delivery of radio frequency energy lo the accessory pathway, has the potential to reduce radiation exposure, improve primary ablation success, and reduce the rate of recurrence and improve safety. This article describes our experience with the CARTO Biosense System relating to setting up the CARTO System specifically for WPW mapping/ablation, and features of the CARTO System, which are particularly advantageous for mapping and ablation of accessory pathways.
lazar: a modular predictive toxicology framework

lazar (lazy structure–activity relationships) is a modular framework for predictive toxicology. Similar to the read across procedure in toxicological risk assessment, lazar creates local QSAR (quantitative structure–activity relationship) models for each compound to be predicted. Model developers can choose between a large variety of algorithms for descriptor calculation and selection, chemical similarity indices, and model building. This paper presents a high level description of the lazar framework and discusses the performance of example classification and regression models.
Towards utilising one-handed multi-digit pressure input

This paper explores the potential uses of pressure input from multiple digits (i.e., all 4 fingers and the thumb) of one hand squeezing a mobile device: multiple digits may provide multiple inputs. The potential advantages for mobile interaction include freeing the second hand for other tasks, and providing access to multiple functions simultaneously. A range of possible interactions is discussed including the benefits and challenges posed by complex pressure-based input on mobile devices. An example usage scenario is described and tested: pressure-based input for simultaneous zooming and rotating in a map task. Results suggest multi-digit pressure input may be a useful means of interaction with mobile devices.
Control of the effective P/O ratio of oxidative phosphorylation in liver mitochondria and hepatocytes.

The control exerted by substrate oxidation reactions, by ATP turnover and by the proton leak over the oxygen consumption rate, the phosphorylation rate, the proton leak rate and the protonmotive force (delta p) in isolated rat liver mitochondria under a range of conditions between non-phosphorylating (State 4) and maximum phosphorylation (State 3) was investigated by using the top-down approach of metabolic control analysis. The experiments were carried out with saturating concentrations of the substrates succinate, glutamate with malate, or pyruvate with malate. The distribution of control was very similar with each of the three substrates. The effective P/O ratio (i.e. not corrected for leak reactions) was also measured; it varied from zero in State 4 to 80-90% of the maximum theoretical P/O ratio in State 3. Under most conditions control over the effective P/O ratio was shared between proton leak (which had negative control) and the phosphorylating subsystem (which had roughly equal positive control); near State 4, substrate oxidation reactions also acquired some control over this ratio. In resting hepatocytes the effective P/O ratio was only 50% of its maximum theoretical value, corresponding to an effective P/O ratio of only 1.3 for complete oxidation of glucose. The effective P/O ratio for intracellular mitochondrial oxygen consumption was 64% of the maximum value. The control coefficient of the mitochondrial proton leak over the effective P/O ratio in cells was -0.34; the control coefficient of phosphorylation reactions over this ratio was 0.31 and the control coefficient of substrate oxidation reactions over the ratio was 0.03, showing how the coupling efficiency in cells can respond sensitively to agents that change the proton leak or the ATP demand, but not to those that change substrate oxidation.
The Blueprint of a Minimal Cell: MiniBacillus

SUMMARY Bacillus subtilis is one of the best-studied organisms. Due to the broad knowledge and annotation and the well-developed genetic system, this bacterium is an excellent starting point for genome minimization with the aim of constructing a minimal cell. We have analyzed the genome of B. subtilis and selected all genes that are required to allow life in complex medium at 37°C. This selection is based on the known information on essential genes and functions as well as on gene and protein expression data and gene conservation. The list presented here includes 523 and 119 genes coding for proteins and RNAs, respectively. These proteins and RNAs are required for the basic functions of life in information processing (replication and chromosome maintenance, transcription, translation, protein folding, and secretion), metabolism, cell division, and the integrity of the minimal cell. The completeness of the selected metabolic pathways, reactions, and enzymes was verified by the development of a model of metabolism of the minimal cell. A comparison of the MiniBacillus genome to the recently reported designed minimal genome of Mycoplasma mycoides JCVI-syn3.0 indicates excellent agreement in the information-processing pathways, whereas each species has a metabolism that reflects specific evolution and adaptation. The blueprint of MiniBacillus presented here serves as the starting point for a successive reduction of the B. subtilis genome.
Application of ultra-thin aluminum oxide etch mask made by atomic layer deposition technique

Ultra-thin layers of aluminum oxide (less than 1 nm) were grown by atomic layer deposition (ALD) technique on hydrogen-terminated silicon substrates. A new technique, called ‘‘plasma defect etching’’, was proposed for the continuity evaluation of such a layer. The layer was examined by using it as a mask in silicon etching at cryogenic temperatures in a DRIE reactor. The etch profile was characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM) techniques. Island formation during initial cycles was confirmed. Thicker aluminum oxide layers (1-5 nm thick) were patterned by wet or dry (plasma) etching and used as a mask for deep silicon etching at cryogenic temperatures in a DRIE reactor, using SF6 and O2 gas mixture. We found aluminum oxide to be an extremely resistant mask, etched only 0.05 nm/min. The value for the Si to Al2O3 selectivity reached 70 000:1.
Anmerkungen zum Studienabbruch

An der Fernuniversitat war schon nach dem ersten Semester des ersten Studienjahres eine relativ hohe Abbruchquote von Studierenden festzustellen. Im ersten Teil der vorliegenden Untersuchung analysiert Peters mogliche Grunde fur diesen Tatbestand vor allem unter soziologischen Aspekten. Um die Abbruchraten zu verringern, wird als eine Moglichkeit ein theoretisches Konzept mit folgenden Schwerpunkten entwickelt: -Zielgerichtetheit der Studierenden (Unterstutzung im Rahmen tutorieller Betreuung und Beratung), -akademische Integration der Studierenden (durch reale und symbolische Interaktionen), -soziale Integration der Studierenden (Uberwindung von Isolation, uber die viele Studierende klagen), -corporate identity (institutionelle Loyalitat, lebendige Institution – und nicht nur burokratischer Apparat). Im zweiten Teil der Studie werden mittels Tabellen und Grafiken statistische Aussagen zum damaligen Stand von Abbruchraten gegeben. Daruber hinaus enthalt dieser Teil einige grafische Darstellungen zur Motivationshohe und ein Konzeptschema fur den Prozess des Studienabbruchs bei Fernstudenten.
Functional integrity in children with anoxic brain injury from drowning

Drowning is a leading cause of accidental injury and death in young children. Anoxic brain injury (ABI) is a common consequence of drowning and can cause severe neurological morbidity in survivors. Assessment of functional status and prognostication in drowning victims can be extremely challenging, both acutely and chronically. Structural neuroimaging modalities (CT and MRI) have been of limited clinical value. Here, we tested the utility of resting‐state functional MRI (rs‐fMRI) for assessing brain functional integrity in this population. Eleven children with chronic, spastic quadriplegia due to drowning‐induced ABI were investigated. All were comatose immediately after the injury and gradually regained consciousness, but with varying ability to communicate their cognitive state. Eleven neurotypical children matched for age and gender formed the control group. Resting‐state fMRI and co‐registered T1‐weighted anatomical MRI were acquired at night during drug‐aided sleep. Network integrity was quantified by independent components analysis (ICA), at both group‐ and per‐subject levels. Functional‐status assessments based on in‐home observations were provided by families and caregivers. Motor ICNs were grossly compromised in ABI patients both group‐wise and individually, concordant with their prominent motor deficits. Striking preservations of perceptual and cognitive ICNs were observed, and the degree of network preservation correlated (ρ = 0.74) with the per‐subject functional status assessments. Collectively, our findings indicate that rs‐fMRI has promise for assessing brain functional integrity in ABI and, potentially, in other disorders. Furthermore, our observations suggest that the severe motor deficits observed in this population can mask relatively intact perceptual and cognitive capabilities. Hum Brain Mapp 38:4813–4831, 2017. © 2017 Wiley Periodicals, Inc.
Evaluating Trade Polices on Intermediate goods

In this paper, we introduce a general equilibrium model of international trade that takes into account the endogenous entry and exit of intermediate goods producers and the industry linkages to quantitatively measure the countries welfare gains and losses from the export and import subsidy policies as in China. Our model extends the inter-industry trade model Eaton and Kortum (2002), intra-industry model of Krugman (1980), and firm heterogeneous model of Melitz (2003). Subsidies on intermediate good imports or export subsidies of specific industries affect welfare of countries through direct effects on wages and cost of input bundles of production (labor and intermediate goods), and indirectly through changes in term of trades, and endogenous entries and exits in many industries due to the general equilibrium adjustment of the input-output linkages which are missed in the Eaton and Kortum (2002) environment. We show that the welfare gain from trade depends on the share of domestic goods in intermediate goods. Moreover, the lower elasticities of substitution of intermediate goods than consumption goods magnifies the welfare gain from trade. JEL classification: F1, F6, F12, F13, F15, F17.
Using technology to create a medication safety net for cardiac surgery patients: a nurse-led randomized control trial.

PURPOSE Interactive voice response (IVR) technology was used to increase medication compliance and reduce adverse events (hospitalization and emergency visits) in post-cardiac surgery patients. METHOD Patients randomized to intervention received 11 automated IVR calls in the six months after discharge. A total of 331 patients (164 IVR, 167 usual care) participated. RESULTS Findings showed significant differences in the IVR group for the primary composite outcome of compliance and adverse events (relative risk (RR] and 95% confidence interval [CI]: 0.60 [0.37, 0.96), p = 0.041) and the secondary outcome of medication compliance (RR: 0.34 (0.20, 0.56), p < 0.0001). There was no significant impact on emergency room visits (RR: 1.04 (0.63, 1.73J) and hospitalization (RR: 0.77 [0.41, 1.45]). Most patients (93%) preferred IVR follow-up to no follow-up.
Complementary Role of Field and Temperature in Triggering ON/OFF Switching Mechanisms in ${\rm Hf}/{\rm HfO}_{2}$ Resistive RAM Cells

We present an investigation on the role of temperature and electric field as driving forces in the initiation of the resistive switching processes. The impact of temperature in both on- and off-states is analyzed in detail, using an electrothermal numerical model formulation. dc and pulsed temperature-dependent data, collected on scaled crossbar test structure cells, serially connected with an on-chip control transistor, are used to extract material information and are furthermore analyzed in conjunction with model outputs. With these results, further discussion is presented, suggesting points of attention for scaled cell design in the below-10-nm realm.