Miracle-dz/UniFAR-FTUs huggingface dataset:
Haemin attenuates intermittent hypoxia‐induced cardiac injury via inhibiting mitochondrial fission

Obstructive sleep apnoea (OSA) characterized by intermittent hypoxia (IH) is closely associated with cardiovascular diseases. IH confers cardiac injury via accelerating cardiomyocyte apoptosis, whereas the underlying mechanism has remained largely enigmatic. This study aimed to explore the potential mechanisms involved in the IH‐induced cardiac damage performed with the IH‐exposed cell and animal models and to investigate the protective effects of haemin, a potent haeme oxygenase‐1 (HO‐1) activator, on the cardiac injury induced by IH. Neonatal rat cardiomyocyte (NRC) was treated with or without haemin before IH exposure. Eighteen male Sprague‐Dawley (SD) rats were randomized into three groups: control group, IH group (PBS, ip) and IH + haemin group (haemin, 4 mg/kg, ip). The cardiac function was determined by echocardiography. Mitochondrial fission was evaluated by Mitotracker staining. The mitochondrial dynamics‐related proteins (mitochondrial fusion protein, Mfn2; mitochondrial fission protein, Drp1) were determined by Western blot. The apoptosis of cardiomyocytes and heart sections was examined by TUNEL. IH regulated mitochondrial dynamics‐related proteins (decreased Mfn2 and increased Drp1 expressions, respectively), thereby leading to mitochondrial fragmentation and cell apoptosis in cardiomyocytes in vitro and in vivo, while haemin‐induced HO‐1 up‐regulation attenuated IH‐induced mitochondrial fragmentation and cell apoptosis. Moreover, IH resulted in left ventricular hypertrophy and impaired contractile function in vivo, while haemin ameliorated IH‐induced cardiac dysfunction. This study demonstrates that pharmacological activation of HO‐1 pathway protects against IH‐induced cardiac dysfunction and myocardial fibrosis through the inhibition of mitochondrial fission and cell apoptosis.
Quantum simulation from the bottom up: the case of rebits

Typically, quantum mechanics is thought of as a linear theory with unitary evolution governed by the Schrödinger equation. While this is technically true and useful for a physicist, with regards to computation it is an unfortunately narrow point of view. Just as a classical computer can simulate highly nonlinear functions of classical states, so too can the more general quantum computer simulate nonlinear evolutions of quantum states. We detail one particular simulation of nonlinearity on a quantum computer, showing how the entire class of -unitary evolutions (on n qubits) can be simulated using a unitary, real-amplitude quantum computer (consisting of n + 1 qubits in total). These operators can be represented as the sum of a linear and antilinear operator, and add an intriguing new set of nonlinear quantum gates to the toolbox of the quantum algorithm designer. Furthermore, a subgroup of these nonlinear evolutions, called the -Cliffords, can be efficiently classically simulated, by making use of the fact that Clifford operators can simulate non-Clifford (in fact, non-linear) operators. This perspective of using the physical operators that we have to simulate non-physical ones that we do not is what we call bottom-up simulation, and we give some examples of its broader implications.
Physical layer security OFDM communication using phased array antenna

In this paper, a new orthogonal frequency-division multiplexing (OFDM) modulation based on phased-array is proposed for wireless physical layer security. By applying distinct initial phases for different subcarriers of the OFDM symbols, the transmitted information will be angle-range-dependent. Numerical results show that, the OFDM symbols are well preserved in the desired location, while these symbols become scrambled in the phase at undesired locations. In doing so, proposed method achieves better secure performance in both angle and range dimensions than the traditional method. Moreover, in the proposed method, the initial phases can be calculated directly from the simple equations rather than time-consuming simulations. This implies that it is easy to implement in practice.
Fuzzy Ontology Mining and Semantic Information Granulation for Effective Information Retrieval Decision Making

The notion of semantic information granulation is explored to estimate the information specificity or generality of documents. Basically, a document is considered more specific than another document if it contains more cohesive domain-specific terminologies than that of the other one. We believe that the dimension of semantic granularity is an important supplement to the existing similarity-based and popularity-based measures for building effective document ranking functions. The main contributions of this paper is the illustration of the design and development of a fuzzy ontology based granular information retrieval (IR) system to improve the effectiveness of IR decision making for various domains. Based on the notion of semantic information granulation, a novel computational model is developed to estimate the semantic granularity of documents; these documents can then be ranked according to the information seekers' specific semantic granularity requirements. One main component of the proposed computatio.
PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1

Significance Genetic alterations targeting the PI3K pathway are highly prevalent in breast cancers. Although breast cancers harboring PIK3CA mutation and HER2 amplification have enhanced sensitivity to PI3K inhibitors, the mechanism underlying this sensitivity is unknown. This study shows that PI3K inhibitors suppress MEK/ERK pathway in these cancers, and inhibition of both AKT and ERK pathways is necessary for maximal antitumoral activity. We elucidate a unique mechanistic link between PI3K and ERK via PI3K-dependent regulation of P-Rex1, which in turn regulates the Rac1/PAK/c-RAF/MEK/ERK pathway. Importantly, expression levels of the Rac-GEF, P-Rex1, correlate with sensitivity to PI3K inhibitors among these breast cancer cell lines, indicating its potential utility as a biomarker to identify cancers that will respond to PI3K inhibitors. The PI3K pathway is genetically altered in excess of 70% of breast cancers, largely through PIK3CA mutation and HER2 amplification. Preclinical studies have suggested that these subsets of breast cancers are particularly sensitive to PI3K inhibitors; however, the reasons for this heightened sensitivity are mainly unknown. We investigated the signaling effects of PI3K inhibition in PIK3CA mutant and HER2 amplified breast cancers using PI3K inhibitors currently in clinical trials. Unexpectedly, we found that in PIK3CA mutant and HER2 amplified breast cancers sensitive to PI3K inhibitors, PI3K inhibition led to a rapid suppression of Rac1/p21-activated kinase (PAK)/protein kinase C-RAF (C-RAF)/ protein kinase MEK (MEK)/ERK signaling that did not involve RAS. Furthermore, PI3K inhibition led to an ERK-dependent up-regulation of the proapoptotic protein, BIM, followed by induction of apoptosis. Expression of a constitutively active form of Rac1 in these breast cancer models blocked PI3Ki-induced down-regulation of ERK phosphorylation, apoptosis, and mitigated PI3K inhibitor sensitivity in vivo. In contrast, protein kinase AKT inhibitors failed to block MEK/ERK signaling, did not up-regulate BIM, and failed to induce apoptosis. Finally, we identified phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 (P-Rex1) as the PI(3,4,5)P3-dependent guanine exchange factor for Rac1 responsible for regulation of the Rac1/C-RAF/MEK/ERK pathway in these cells. The expression level of P-Rex1 correlates with sensitivity to PI3K inhibitors in these breast cancer cell lines. Thus, PI3K inhibitors have enhanced activity in PIK3CA mutant and HER2 amplified breast cancers in which PI3K inhibition down-regulates both the AKT and Rac1/ERK pathways. In addition, P-Rex1 may serve as a biomarker to predict response to single-agent PI3K inhibitors within this subset of breast cancers.
A qualitative study of the experience of lower extremity wounds and amputations among people with diabetes in Philadelphia

The purpose of this study was to explore perceptions among people with type 2 diabetes about foot ulcers and lower extremity amputations. This was a qualitative observational study utilizing open‐ended, semistructured interviews of 39 people with diabetes who were purposively selected because they had either a foot ulcer (n = 19) or a lower extremity amputation (n = 20). Interviews were audio‐recorded, deidentified, and entered into NVivo 10.0 for coding and analysis. Our integrated analytic approach combined inductively and deductively derived codes that were applied to all transcripts. Coded data were summarized and examined for patterns. Participants' description of the relationship between diabetes and their foot ulcer or amputation revealed a limited understanding of the disease process. Disruption and loss of independence was expressed whether the person had a foot ulcer or an amputation. Treatment recommendations for foot ulcers were viewed by most as extremely difficult. Amputation was a feared outcome, but some learned to adapt and, at times felt that the amputation enhanced their quality of life. Clinicians have assumed that a focus on limb salvage is preferred over a major amputation. However, because of the complexity of care requiring frequent healthcare provider visits, the frequency of care failure, the frequency of recurrence, and mortality associated with having had a foot ulcer, it may be more appropriate for clinicians to prioritize quality‐of‐life salvage. Foot ulcer treatment failure may be due to a lack of providers' understanding of the impact of treatment on a patient's life.
Bi-scale appearance fabrication

Surfaces in the real world exhibit complex appearance due to spatial variations in both their reflectance and local shading frames (i.e. the local coordinate system defined by the normal and tangent direction). For opaque surfaces, existing fabrication solutions can reproduce well only the spatial variations of isotropic reflectance. In this paper, we present a system for fabricating surfaces with desired spatially-varying reflectance, including anisotropic ones, and local shading frames. We approximate each input reflectance, rotated by its local frame, as a small patch of oriented facets coated with isotropic glossy inks. By assigning different ink combinations to facets with different orientations, this bi-scale material can reproduce a wider variety of reflectance than the printer gamut, including anisotropic materials. By orienting the facets appropriately, we control the local shading frame. We propose an algorithm to automatically determine the optimal facets orientations and ink combinations that best approximate a given input appearance, while obeying manufacturing constraints on both geometry and ink gamut. We fabricate the resulting surface with commercially available hardware, a 3D printer to fabricate the facets and a flatbed UV printer to coat them with inks. We validate our method by fabricating a variety of isotropic and anisotropic materials with rich variations in normals and tangents.
NLRP3 expression and urinary HSP72 in relation to biomarkers of inflammation and oxidative stress in diabetic nephropathy patients

Diabetic nephropathy (DN) is one of the major causes of end‐stage renal disease. Nod‐like receptors nucleotide‐binding domain and leucine‐rich repeat pyrin‐3 domain (NLRP3) inflammasome displays a considerable role in the chronic inflammatory state observed in diabetic patients. Urinary heat shock protein 72 (uHSP72) is a sensitive and specific biomarker for the early detection of acute kidney injury. The aim of this study was to evaluate NLRP3 relative gene expression, its correlation with inflammatory and oxidative stress markers, and to assess the value of uHSP72 in the early detection of DN in type 2 diabetic patients with different degrees of DN. Forty‐five type 2 diabetic patients: 15 normoalbuminuric, 15 microalbuminuric, 15 macroalbuminuric, in addition to 15 healthy controls were enrolled in this study. Clinical examination and routine laboratory investigations were performed. NLRP3 mRNA expression was assessed by real time polymerase chain reaction. Serum 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), interleukin 1β (IL‐1β), and uHSP72 levels were estimated by enzyme‐linked immunosorbent assay. Serum chitotriosidase (CHIT1) activity was examined. NLRP3 mRNA relative expression, serum levels of 8‐OHdG, IL‐1β, and uHSP72, in addition to CHIT 1 activity were significantly increased in the macroalbuminuric patient group as compared to control and the other two diabetic groups. Also, a significant positive correlation was documented between the previously mentioned parameters and urinary albumin/creatinine ratio, serum creatinine, and HbA1c. Multiple linear regression analysis using urinary albumin/creatinine ratio as dependent variable confirmed that uHSP72 and NLRP3 mRNA relative expression were the independent predictors of DN (β were 0.432 and 0.448 respectively, P < 0.001). Receiver operating characteristic analyses revealed that both NLRP3 mRNA relative expression and uHSP72 levels were useful biomarkers discriminating DN patients from patients with type 2 diabetes mellitus (AUC were 0.957 and 0.983, respectively). uHSP72 may be considered as a novel potential diagnostic biomarker for the early detection of DN. Moreover, these data support the pivotal role of NLRP3 in the development and progression of DN. © 2017 IUBMB Life, 69(8):623–630, 2017
Fuzzy Specification in Real Estate Market Decision Making

In this paper we present a software tool designed as a decision aid system for all actors being involved when buying or selling real state, client and realtor, where a main objective for the commercial is to concentrate the client preferences into few alternatives. Since the required previous analysis implies a number of fuzzy concepts, the general procedure here presented considers fuzzy logic to deal with specifications. As a consequence, time devoted to elicitation and requirement analysis is reduced.
The strength of weight‐bearing bones is similar in amenorrheic and eumenorrheic elite long‐distance runners

Regular intense endurance exercise can lead to amenorrhea with possible adverse consequences for bone health. We compared whole body and regional bone strength and skeletal muscle characteristics between amenorrheic (AA: n = 14) and eumenorrheic (EA: n = 15) elite adult female long‐distance runners and nonathletic controls (C: n = 15). Participants completed 3‐day food diaries, dual‐energy X‐ray absorptiometry (DXA), magnetic resonance imaging (MRI), peripheral quantitative computed tomography (pQCT), and isometric maximal voluntary knee extension contraction (MVC). Both athlete groups had a higher caloric intake than controls, with no significant difference between athlete groups. DXA revealed lower bone mineral density (BMD) at the trunk, rib, pelvis, and lumbar spine in the AA than EA and C. pQCT showed greater bone size in the radius and tibia in EA and AA than C. The radius and tibia of AA had a larger endocortical circumference than C. Tibia bone mass and moments of inertia (Ix and Iy) were greater in AA and EA than C, whereas in the radius, only the proximal Iy was larger in EA than C. Knee extensor MVC did not differ significantly between groups. Amenorrheic adult female elite long‐distance runners had lower BMD in the trunk, lumbar spine, ribs, and pelvis than eumenorrheic athletes and controls. The radius and tibia bone size and strength indicators were similar in amenorrheic and eumenorrheic athletes, suggesting that long bones of the limbs differ in their response to amenorrhea from bones in the trunk.
Modeling the Intransitive Pairwise Image Preference from Multiple Angles

Among the previous studies in modeling users' preference on images, most of them assume there is a consistent ranking of images, and users' preference is transitive. That is, if a user likes image A over B and B over C, it must have A over C for this user. This condition holds when user compares images from a single angle. However, if there are multiple angles to consider, users' preference may not be transitive at all. Thus, it is interesting to know whether users' pairwise preference on images can be intransitive, and how can such personalized intransitivity be modeled. In this paper, the problem of modeling the intransitive pairwise image preference is studied, and a family of multi-angle preference models based on pairwise image comparisons are proposed to tackle this problem. These models separately consider users' most-like angles, least-like angles and the balance between two sides towards different images. This study attempts to find the angles that each user selects to evaluate images as well as the angles that each image attracts general users. The experimental results on two real-world data sets show superior performance of the proposed models.
Direct peroral cholangioscopy for diagnosis of bile duct lesions using an I-SCAN ultraslim endoscope: a pilot study

Abstract Background and study aims I-SCAN is a computed virtual chromoendoscopy (CVC) system designed to enhance surface and vascular patterns. In this study, we evaluated the usefulness of direct peroral cholangioscopy (POC) using I-SCAN compared with a conventional white-light image (WLI) to diagnose bile duct lesions. Patients and methods Patients with mucosal lesions in the bile duct detected during direct POC were enrolled prospectively. The quality of endoscopic visualization and the visual diagnosis were assessed using I-SCAN and WLI modes, respectively, during direct POC. Results A total of 20 patients (9 malignant and 11 benign lesions) underwent I-SCAN to evaluate lesions in the bile duct using direct POC. The quality of endoscopic visualization using direct POC with I-SCAN was significantly higher than that of WLI for surface structure (P = 0.04), surface microvascular architecture (P = 0.01), and margins (P = 0.02). Overall diagnostic accuracy of the visual diagnosis was not different between I-SCAN and WLI (90.0 % vs. 75.0 %; P = 0.20). Conclusion Direct POC using CVC by I-SCAN seems to be helpful for evaluating mucosal lesions of the bile duct, without the interference from bile. Clinical trial registration: UMIN000021009
SLC6A4 promoter region methylation and socio-emotional stress response in very preterm and full-term infants.

AIM The present study is part of a prospective micro-longitudinal research project and reports on the association between SLC6A4 methylation and socio-emotional stress response in very preterm (VPT) and full-term (FT) infants. MATERIALS & METHODS SLC6A4 methylation was assessed at birth and discharge in 32 VPT infants, and at birth in 27 FT infants. Socio-emotional stress response (i.e., negative emotionality) was assessed at 3 months (corrected age). RESULTS Negative emotionality was higher in VPTs compared with FT counterpart. In VPT infants only, stress response was associated with SLC6A4 methylation status at discharge, which was predictive of greater negative emotionality. CONCLUSION The present study extends previous reports, suggesting that altered SLC6A4 methylation associates with greater socio-emotional stress sensitivity in 3-month-old VPT infants.
Long-term Carriage of Extended-Spectrum &bgr;-Lactamase–Producing Escherichia coli and Klebsiella pneumoniae in the General Population in The Netherlands

Background This longitudinal study aimed to investigate (risk factors for) persistence of carriage and molecular characteristics of extended-spectrum and plasmid-encoded AmpC β-lactamase-producing (ESBL/pAmpC) Escherichia coli and Klebsiella pneumoniae (ESBL-E/K) in adults in the Dutch community. Methods Following a cross-sectional study (ESBL-E/K prevalence, 4.5%), a subset of ESBL-E/K-positive (n = 76) and -negative (n = 249) individuals volunteered to provide 5 monthly fecal samples and questionnaires. ESBL-E/K was cultured using selective enrichment/culture, and multilocus sequence types (MLSTs) were determined. ESBL/pAmpC-genes were analyzed using polymerase chain reaction (PCR) and sequencing. Plasmids were characterized and subtyped by plasmid MLST. Risk factors for persistent carriage were analyzed using logistic regression. Results Of the initially ESBL-E/K-positive participants, 25 of 76 (32.9%) remained positive in all subsequent samples; 51 of 76 persons (67.1%) tested ESBL-E/K negative at some time point during follow-up, of which 31 (40.8%) stayed negative throughout the longitudinal study. Carriers often carried the same ESBL gene and plasmid, but sometimes in different ESBL-E/K strains, indicative for horizontal transfer of plasmids. Of the 249 initially ESBL-E/K-negative participants, the majority (n = 218 [87.6%]) tested negative during 8 months of follow-up, whereas 31 of 249 (12.4%) participants acquired an ESBL-E/K. Escherichia coli phylogenetic group B2 and D and travel to ESBL high-prevalence countries were associated with prolonged carriage. Conclusions ESBL-E/K carriage persisted for >8 months in 32.9% of the initially ESBL-positive individuals, while 12.4% of initially negative individuals acquired ESBL-E/K during the study. A single positive test result provides no accurate prediction for prolonged carriage. Acquisition/loss of ESBL-E/K does not seem to be a random process, but differs between bacterial genotypes.
Compact Roving for Improved Quality of Ring Spunyarn

This article is concerned with the development of a compact system suitable for producing compact roving. The objective is to reduce twist and improve the performance of roving in the subsequent processes. Combed compact cotton yarn with a linear density of 9.84tex was spun from compact and conventional roving. In order to conclude that compactness had been formed in roving, two special tests, namely the minimum twist of cohesion and roving cohesion strength were determined. Yarns produced from conventional and compact roving were compared for their strength, evenness and hairiness. The results show that there was an improvement in the strength and hairiness of the compact yarns produced from compact roving when compared to conventional yarns.