Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlative microscopy - seeing at different angles

Microscopic techniques allow to investigate samples based on various contrasts such as optical, electron or magnetic. Although specialized microscopic techniques often yield convincing and sufficient information, there are many systems where just one kind of contrast does not give the whole picture and needs complementary technique. A well-known example is the combination of electron and optical microscopy especially in biological applications: Where electron microscopy gives insight into the molecular dimensions with nanometre resolution, it can not elucidate the dynamics of the biological system. This dynamic is easily visualized by optical methods, which miss the sub-wavelength resolution. The application of such two complementary methods is known as multi-modal or complementary microscopy.
A review of dentin adhesives in pediatric dentistry

Evolution of the different generations of dentin adhesives has been based on extensive clinical and laboratory research, which recognizes the problems related to bonding properties. The purpose of this paper is to provide an update on the current development in dentin adhesives. Special consideration is given to bonding to dentin in primary teeth and the clinical application of adhesives in pediatric dentistry.
Co-Curing of EPDM and Diene Rubbers by Grafting Accelerators Onto EPDM

Abstract The object of this work was to find ways to co-cure blends of EPDM and diene rubbers for improved properties. We found that by grafting accelerators onto EPDM we obtain excellent cure compatibility between EPDM and natural rubber. The modified EPDM rubbers were obtained by reacting a benzene solution of EPDM with either 4,4′-dithiobismorpholine or 2-mereaptobenzothiazole (MBT). A method which grafts MBT onto EPDM in the presence of tert-butyl hypochlorite or other halogen donors is more versatile, and can be used for various EPDM rubbers regardless of the nature of the termonomers. We have proposed possible mechanisms by which the modified EPDM rubbers co-cure with natural rubber or other diene rubbers. In these mechanisms we point out the importance of the presence or the in situ formation of reactive sites in modified EPDM rubbers.
A survey of address translation technologies for flash memories

Flash is a type of Electronically Erasable Programmable Read-Only Memory (EEPROM). Different from traditional magnetic disks, flash memories have no moving parts and are purely electronic devices, giving them unique advantages, such as lower access latency, lower power consumption, higher density, shock resistance, and lack of noise. However, existing applications cannot run directly on flash memories due to their special characteristics. Flash Translation Layer (FTL) is a software layer built on raw flash memories that emulates a normal block device like magnetic disks. Primary functionalities of the FTL include address translation, garbage collection, and wear leveling. This survey focuses on address translation technologies and provides a broad overview of existing schemes described in patents, journals, and conference proceedings.
PRESSURELESS SINTERING OF SILICON CARBIDE NANOCOMPOSITE CERAMICS

With silicon carbide (SiC) granulation powder containing 5% in mass nano-titanium nitride (TiN) particles prepared by spray drying technique as starting material,SiC nanocomposite ceramics were prepared using pressureless sintering.The effects of sintering temperature and time on the sintering behaviors and microstructure of composite ceramics were studied.The results show that the silicon carbide ceramics can achieve high densification while crystals do not grow up obviously by two-stages sintering.The SiC nanocomposite ceramic sintered at 1 850 ℃ for 1 h after at 1 950 ℃ for 15 min has higher contractiveness,lower mass loss and higher relative density.The nano-TiN particles could partly react with matrix (SiC and Al2O3) to produce TiC and AlN,which obviously enhances the sintering behaviors of SiC ceramics and obtains the silicon carbide ceramics with fine microstructure,equiaxed crystals,and predominant mechanical properties.
Cancer-associated venous thromboembolism: Burden, mechanisms, and management

Summary Venous thromboembolism (VTE) is a significant health problem in the general population but especially in cancer patients. In this review, we discuss the epidemiology and burden of the disease, the pathophysiology of cancer-associated VTE, and the clinical treatment options for both primary prevention and acute treatment. Overall, the development of VTE in cancer patients is related to increases in morbidity, mortality, and medical costs. However, the incidence of cancer-associated VTE varies due to patient-related factors (e.g. thrombophilia, comorbidities, performance status, history of venous diseases), tumour-related factors (e.g. cancer site, stage, grade), and treatment-related factors (e.g. surgery, chemotherapy, anti-angiogenesis treatment, hormonal and supportive treatment). Furthermore, blood count parameters (e.g. platelets and leukocytes) and biomarkers (e.g. soluble P-selectin and D-dimer) are predictive markers for the risk of VTE in cancer patients and have been used to enhance risk stratification. Evidence suggests that cancer itself is associated with a state of hypercoagulability, driven in part by the release of procoagulant factors, such as tissue factor, from malignant tissue as well as by inflammation-driven activation of endothelial cells, platelets, and leukocytes. In general, low-molecular-weight heparin (LWMH) monotherapy is the standard of care for the management of cancer-associated VTE, as vitamin K antagonists are less effective in cancer patients. Direct oral anticoagulants (DOACs) offer a potentially promising treatment option for cancer patients with VTE, but recommendations concerning the routine use of DOACs should await head-to-head studies with LMWH.
How Do Relationship Maintenance Behaviors Affect Individual Well-Being?

How do relationship maintenance behaviors affect individual well-being? Given that people who invest time and effort toward achieving important goals see their outcomes as more reflective of their skills and abilities than do people who invest less time and effort, engaging in relationship maintenance behaviors may lead people to experience increased individual well-being when those behaviors appear to be successful but decreased well-being when they appear to be unsuccessful. A diary study of romantic relationships, a diary study of friendships, and a longitudinal study of newlyweds provided support for this prediction. In all three studies, relationship maintenance behaviors were negatively associated with depressive mood when followed by relatively high relationship quality, but positively associated with depressive mood when followed by relatively low relationship quality. Accordingly, relationship maintenance processes are not inherently beneficial or harmful; their intrapersonal implications depend on the context in which they occur.
A New Approach for Integrating Proactive and Reactive Routing in Mobile Ad Hoc Networks

In this article, we propose a new approach to integrate proactive and reactive routing in mobile ad hoc networks. Our work deploys a lightweight proactive algorithm that runs in the background offering a basic routing service, and a reactive algorithm that can be called on demand offering a connection-oriented routing service. The reactive algorithm relies for its working as much as possible on the routing information provided by the proactive algorithm, creating a synergy between the two parts of our system. The most interesting property of our system is that it allows the choice between proactive and reactive routing to be made for each session individually, by their source nodes. This allows to shift the load of data that is being routed proactively and reactively while the network is being deployed. Also, it gives network nodes a very fine-grained level of control over the routing process, and allows them to maximally exploit the complementary properties of proactive and reactive routing, for example by matching the choice of the routing approach to the needs of individual sessions. In a range of tests, we show the validity of our approach.
Transcranial Alternating Current Stimulation Modulates Risky Decision Making in a Frequency-Controlled Experiment

Abstract In this study, we investigated the effect of transcranial alternating current stimulation (tACS) on voluntary risky decision making and executive control in humans. Stimulation was delivered online at 5 Hz (θ), 10 Hz (α), 20 Hz (β), and 40 Hz (γ) on the left and right frontal area while participants performed a modified risky decision-making task. This task allowed participants to voluntarily select between risky and certain decisions associated with potential gains or losses, while simultaneously measuring the cognitive control component (voluntary switching) of decision making. The purpose of this experimental design was to test whether voluntary risky decision making and executive control can be modulated with tACS in a frequency-specific manner. Our results revealed a robust effect of a 20-Hz stimulation over the left prefrontal area that significantly increased voluntary risky decision making, which may suggest a possible link between risky decision making and reward processing, underlined by β-oscillatory activity.
Everybody Else Is Doing It: Exploring Social Transmission of Lying Behavior

Lying is a common occurrence in social interactions, but what predicts whether an individual will tell a lie? While previous studies have focused on personality factors, here we asked whether lying tendencies might be transmitted through social networks. Using an international sample of 1,687 socially connected pairs, we investigated whether lying tendencies were related in socially connected individuals, and tested two moderators of observed relationships. Participants recruited through a massive open online course reported how likely they would be to engage in specific lies; a friend or relative responded to the same scenarios independently. We classified lies according to their beneficiary (antisocial vs. prosocial lies), and their directness (lies of commission vs. omission), resulting in four unique lying categories. Regression analyses showed that antisocial commission, antisocial omission, and prosocial commission lying tendencies were all uniquely related in connected pairs, even when the analyses were limited to pairs that were not biologically related. For antisocial lies of commission, these relationships were strongest, and were moderated by amount of time spent together. Randomly paired individuals from the same countries were also related in their antisocial commission lying tendencies, signifying country-level norms. Our results indicate that a person's lying tendencies can be predicted by the lying tendencies of his or her friends and family members.
Epoxy solder paste and its applications

Epoxy solder paste and its applications Jong-Tae Moon*, Yong-Sung Eom** and Jong-Hyun Lee***,† *Hojeonable, Inc. Daejeon 305-510, Korea **Energy Transfer Device Lab. , Electronics and Telecommunications Research Institute (ETRI), Daejeon 305-700, Korea ***Department of Materials Science and Engineering, Seoul National University of Science and Technology, Seoul 139-743, Korea †Corresponding author : pljh@snut.ac. kr (Received June 22, 2015 ; Accepted June 25, 2015)
Overlap Set Similarity Joins with Theoretical Guarantees

This paper studies the set similarity join problem with overlap constraints which, given two collections of sets and a constant c, finds all the set pairs in the datasets that share at least c common elements. This is a fundamental operation in many fields, such as information retrieval, data mining, and machine learning. The time complexity of all existing methods is O(n2) where n is the total size of all the sets. In this paper, we present a size-aware algorithm with the time complexity of O(n2-over 1 c k1 over 2c)=o(n2)+O(k), where k is the number of results. The size-aware algorithm divides all the sets into small and large ones based on their sizes and processes them separately. We can use existing methods to process the large sets and focus on the small sets in this paper. We develop several optimization heuristics for the small sets to improve the practical performance significantly. As the size boundary between the small sets and the large sets is crucial to the efficiency, we propose an effective size boundary selection algorithm to judiciously choose an appropriate size boundary, which works very well in practice. Experimental results on real-world datasets show that our methods achieve high performance and outperform the state-of-the-art approaches by up to an order of magnitude.
Simultaneous correspondence and non-rigid 3D reconstruction of the coronary tree from single X-ray images

We present a novel approach to simultaneously reconstruct the 3D structure of a non-rigid coronary tree and estimate point correspondences between an input X-ray image and a reference 3D shape. At the core of our approach lies an optimization scheme that iteratively fits a generative 3D model of increasing complexity and guides the matching process. As a result, and in contrast to existing approaches that assume rigidity or quasi-rigidity of the structure, our method is able to retrieve large non-linear deformations even when the input data is corrupted by the presence of noise and partial occlusions. We extensively evaluate our approach under synthetic and real data and demonstrate a remarkable improvement compared to state-of-the-art.
Distribution and Molecular Characterization of an Alien Fungus, Clathrus archeri, in Poland

Clathrus archeri is a saprotrophic fungus native to Australia and New Zealand and known in Europe since the beginning of the 20th century. In Poland, C. archeri was recorded for the fi rst time in 1973 and since then basidiomata of this fungus have been recorded almost 90 times, mostly in the southern part of the country. In the present study, we update the distribution of C. archeri in Poland and include the latest records from Central Poland. We show a signifi cant increase in the number of C. archeri observations in recent years (R2 = 0.400, p<0.001). Our research shows that precipitation should be regarded as an important factor in the spread of C. archeri. Additionally, intraspecifi c genetic variability of nrRNA of C. archeri from different localities in Poland has been determined. Obtained results indicate zero to low levels of diversity in the nrITS and nrLSU sequences obtained from 16 C. archeri basidiomata from different localities in Poland (evolutionary divergence between sequences up to 0.002 and 0.001 for nrITS and nrLSU, respectively). Finally we identify some limitations in this research and make suggestions for future studies of pathways of the distribution of this fungus in the new area.
The Reversal Effects of 3-Bromopyruvate on Multidrug Resistance In Vitro and In Vivo Derived from Human Breast MCF-7/ADR Cells

Purpose P-glycoprotein mediated efflux is one of the main mechanisms for multidrug resistance in cancers, and 3-Bromopyruvate acts as a promising multidrug resistance reversal compound in our study. To test the ability of 3-Bromopyruvate to overcome P-glycoprotein-mediated multidrug resistance and to explore its mechanisms of multidrug resistance reversal in MCF-7/ADR cells, we evaluate the in vitro and in vivo modulatory activity of this compound. Methods The in vitro and in vivo activity was determined using the MTT assay and human breast cancer xenograft models. The gene and protein expression of P-glycoprotein were determined using real-time polymerase chain reaction and the Western blotting technique, respectively. ABCB-1 bioactivity was tested by fluorescence microscopy, multi-mode microplate reader, and flow cytometry. The intracellular levels of ATP, HK-II, and ATPase activity were based on an assay kit according to the manufacturer’s instructions. Results 3-Bromopyruvate treatment led to marked decreases in the IC50 values of selected chemotherapeutic drugs [e.g., doxorubicin (283 folds), paclitaxel (85 folds), daunorubicin (201 folds), and epirubicin (171 folds)] in MCF-7/ADR cells. 3-Bromopyruvate was found also to potentiate significantly the antitumor activity of epirubicin against MCF-7/ADR xenografts. The intracellular level of ATP decreased 44%, 46% in the presence of 12.5. 25 µM 3-Bromopyruvate, whereas the accumulation of rhodamine 123 and epirubicin (two typical P-glycoprotein substrates) in cells was significantly increased. Furthermore, we found that the mRNA and the total protein level of P-glycoprotein were slightly altered by 3-Bromopyruvate. Moreover, the ATPase activity was significantly inhibited when 3-Bromopyruvate was applied. Conclusion We demonstrated that 3-Bromopyruvate can reverse P-glycoprotein-mediated efflux in MCF-7/ADR cells. Multidrug resistance reversal by 3-Bromopyruvate occurred through at least three approaches, namely, a decrease in the intracellular level of ATP and HK-II bioactivity, the inhibition of ATPase activity, and the slight decrease in P-glycoprotein expression in MCF-7/ADR cells.
Review of Newtonian and non-Newtonian fluids behaviour in the context of grouts

The objective of this review is to elucidate the rheological behavior of cement based grout. Rheology of grouts is a way of describing its properties without paying any attention to whether it is a homogenous grout or a mixture of grains in a grout. Cement grout based rheology is characterized by at least two parameters; yield stress and plastic viscosity. The rheological models are used to describe the relationship between shear stress and shear rate. The Newtonian fluids are true fluids that tend to exhibit constant viscosity at all shear rates. A non-Newtonian fluid is a fluid for which the relationship τ/γ′ is not a constant. Pseudo-plasticity or shear thinning is the most common type of time-independent and non-Newtonian fluid behavior observed. It is characterized by an apparent viscosity which decreases with an increasing shear rate. Many mathematical models for fluids behavior have been proposed to model the shear thinning characteristics. These models are based on curve fitting method that gives empirical relationships for the shear stress vs. shear rate curves. Some models are based on the statistical mechanics. The Bingham model does not give an exact description of the behavior of a cement based grout even if the geometry is defined, but there are other models and the selection of model should be done carefully based on the requirement. eters of fluids much useful behavioral and predictive information can be obtained. These include quality control, chemical, mechanical, and thermal treatments, effects of additives on the curing reaction, and direct assessment of the process ability. Furthermore, the rheological measurements may also be used as an indicator of micro structural changes occurring in hydration of the cementbased grout or the investigation of the effect of admixtures, and the development of cementitious systems that are easily pumped or placed (Struble and Ji, 2001). Hånsson (1993) stated that the rheological behavior of a cement-based grout is difficult to define because of the concentration and characteristics of the particles as well as the suspension medium. The rheological behavior is influenced by the chemical reactions in progress during the hydration of the cement and the thixotropy is dominant at short cycle times. The rheological models are used to describe the relationship between shear stress and shear rate. Syrjålå (1996) stated that there was no general rheological constitutive model
Genetic Diversity, Molecular Phylogeny, and Selection Evidence of Jinchuan Yak Revealed by Whole-Genome Resequencing

Jinchuan yak, a newly discovered yak breed, not only possesses a large proportion of multi-ribs but also exhibits many good characteristics, such as high meat production, milk yield, and reproductive performance. However, there is limited information about its overall genetic structure, relationship with yaks in other areas, and possible origins and evolutionary processes. In this study, 7,693,689 high-quality single-nucleotide polymorphisms were identified by resequencing the genome of Jinchuan yak. Principal component and population genetic structure analyses showed that Jinchuan yak could be distinguished as an independent population among the domestic yak population. Linkage disequilibrium analysis showed that the decay rate of Jinchuan yak was the lowest of the domestic yak breeds, indicating that the degree of domestication and selection intensity of Jinchuan yak were higher than those of other yak breeds. Combined with archaeological data, we speculated that the origin of domestication of Jinchuan yak was ∼6000 yr ago (4000–10,000 yr ago). The quantitative dynamics of population growth history in Jinchuan yak was similar to that of other breeds of domestic and wild yaks, but was closer to that of the wild yak. No significant gene exchange between Jinchuan and other domestic yaks occurred. Compared with other domestic yaks, Jinchuan yak possessed 339 significantly and positively selected genes, several of which relate to physiological rhythm, histones, and the breed’s excellent production characteristics. Our results provide a basis for the discovery of the evolution, molecular origin, and unique traits of Jinchuan yak.
Vaccination of lambs against Haemonchus contortus with the recombinant rHc23. Effect of adjuvant and antigen dose

Haemonchus contortus is the most pathogenic gastrointestinal helminth of small ruminants. Natural or experimental repeated infections and several native antigens confer a partially protective immune response but vaccination with subunit antigens has been elusive. Promising results have been obtained with a recombinant form of a somatic antigen (rHc23). In this paper we present the results obtained in vaccination trials in lambs using two dosages of rHc23 and standard adjuvants. Six-months old Manchego females lambs were vaccinated with rHc23 (50 or 200 μg/dose) adjuvanted with 1mL aluminum hydroxide on days -42, -28 and -14 or with 200 μg/dose rHc23 and 5 mg Quil A on days -49, -28 and -7. Control lambs were kept receiving only the adjuvants the same days or no treatment. Moreover one group did not receive any treatment or infection. On day 0 vaccinated lambs, untreated animals and those receiving the adjuvant were infected per os with a monospecific single infection of 4000 L3 of H. contortus. Infection was kept for 58 days and follow-up included the determination of serum specific antibody response (ELISA, WB), hematological parameters (eosinophil counts, hematocrit) and fecal egg counts (epg). Absence of hematocrit alterations, reduction of helminth’s eggs output and abomasal parasite burden at the end of the experiment were the efficacy criteria of vaccination with the recombinant. Immunization with both adjuvants and antigen dosages elicited strong antibody responses particularly with Quil A. Vaccinated groups showed significant reduction of fecal egg excretion and abomasal helminth burdens. Highest protection of lambs against challenge was achieved with aluminum hydroxide and 200 μg/dose rHc23 with a reduction of over 70% of the abomasal burden and over 80% of fecal egg output. Results suggest that rHc23 could be a valuable recombinant candidate for vaccination against haemonchosis. No clear relationship was found between antibody levels and protection this pointing towards involvement of both humoral and cellular components in the protective response elicited by rHc23.