Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors associated with medication adherence among heart failure patients and their caregivers.

BACKGROUND Reducing the rate of rehospitalization among heart failure patients is a major public health challenge; medication non-adherence is a crucial factor shown to trigger rehospitalizations. Objective: To collect pilot data to inform the design of educational interventions targeted to heart failure patients and their caregivers to improve medication adherence. METHODS Heart failure patients with an implantable cardioverter defibrillator and their family caregivers were recruited from an outpatient electrophysiology clinic at an urban university medical center (N = 10 caregiver and patient dyads, 70% race/ethnic minority, mean patient age = 63 years). Quantitative and qualitative research methods were utilized. Semi-structured individual interviews were conducted to assess patients' and caregivers' individual interest in, and access to, new medication adherence technologies. Patient adherence to medications, medication self-efficacy, and depression were assessed by validated questionnaires. Medication adherence and hospitalization rates were assessed among patients at 30-days post-clinic visit by mailed survey. RESULTS At baseline, 60% of patients reported sometimes forgetting to take their medications. The most common factors associated with non-adherence included forgetfulness (50%), having other medications to take (20%), and being symptom-free (20%). At 30-day follow-up, half of patients reported non-adherence to their medications, and 1 in 10 reported being hospitalized within the past month. Dyads reported widespread access to technology, with the majority of dyads showing interest in mobile applications and text messaging. There was less acceptance of medication-dispensing technologies; caregivers and patients were concerned about added burden. CONCLUSIONS The majority of etiologies of medication non-adherence were subject to intervention. Enthusiasm from patients and caregivers in new technologies to aid in adherence was tempered by potential burden, and should be considered when designing interventions to promote adherence.
Naphthalene-1,8-dicarboxylic anhydride: a monoclinic polymorph

A new type of naphthalene-1,8-dicarboxylic anhydride, C12H6O3, was synthesized hydrothermally. Unlike the two previously reported polymorphs, which crystallize in the orthorhombic space groups P212121 [Shok et al. (1971). Kristallografiya, 16, 500–502; Grigor’eva & Chetkina (1975). Kristallografiya, 20, 1289–1290] and Pbca [Shok & Gol’der (1970). Zh. Strukt. Khim. 11, 939–940], this present structure crystallizes in the monoclinic space group P21 /c. In this structure, the planar [total puckering amplitude Q = 0.0362 (15)] molecules lie parallel to each other along the a axis.
Rapid mass spectrometric identification of proteins from two‐dimensional polyacrylamide gels after in gel proteolytic digestion

We report a rapid method for identifying proteins resolved by two‐dimensional polyacrylamide gel electrophoresis (2‐D PAGE) using matrix‐assisted laser desorption ionization‐mass spectrometry (MALDI‐MS). In‐gel digestion was performed in a way such that the volume ratio of trypsin solution to gel plug was quantitatively controlled to promote reproducible digestion and to maximize the digestion yield. To make the digestion samples more compatible with MALDI‐MS, the volatile salt ammonium bicarbonate in the digestion buffer was largely removed prior to peptide extraction. Samples of mixed tryptic peptides from in‐gel digestion were used without purification to obtain molecular weights by MALDI‐MS with α‐cyano, 4‐hydroxy‐cinnamic acid as the matrix. Modifications of MALDI sample loading procedures improved the detetion sensitivity by one half to one order of magnitude. The peptide mass peaks in MALDI‐MS spectra were distinguished from those of impurities by using several types of controls, and masses were corrected by using trypsin autodigestion fragments as internal calibration standards. Two different peptidematching computer programs were used to interrogate sequence databases and identify proteins. Identification was enhanced by generation of orthogonal data sets (by using different proteases) and by including experimental values of isoelectric point (pI) and molecular weight to exclude false entries in the candidate lists. Approximately 1% of the material from a spot was used in each sample loading, and nine protein spots from rat liver 2‐D PAGE gels were identified correctly, as judged by comparison with identification results previously obtained from Edman sequencing. A previously identified low‐abundance spot was not identified by MALDI‐MS, presumably because there was insufficient material in a single gel. The sample handling procedure reported here should permit us to identify many 2‐D PAGE protein spots of medium abundance.
Mixed pathology is more likely in black than white decedents with Alzheimer dementia

Objective: To compare the burden of neuropathology in black and white participants with clinical Alzheimer disease (AD). Methods: Participants included 122 persons enrolled in the Rush Alzheimer's Disease Clinical Core, a prospective cohort study of AD. Forty-one black decedents were matched two-to-one to 81 white decedents according to age at death, sex, years of education, and cognition proximate to death. We examined common brain pathologies related to dementia (AD, Lewy body, and macroscopic and microinfarct pathology) and arteriolar sclerosis and atherosclerosis. We calculated the frequency of each dementia pathology both alone and in combination (mixed pathologies). Racial differences in the odds of a single pathology vs mixed pathologies, and in the odds of vessel disease and its severity, were examined using logistic regression analyses. Results: AD pathology was confirmed in >93% of both black and white decedents with AD dementia. However, black decedents were less likely to have Alzheimer pathology as a single dementia pathology than white decedents (19.5% vs 42.0%), and were more likely to have AD mixed with an additional pathology (70.7% vs 50.6%), particularly Alzheimer pathology and Lewy bodies, and Alzheimer pathology, Lewy bodies, and infarcts. Black decedents also had more severe arteriolar sclerosis and atherosclerosis. Conclusion: Black decedents with AD dementia are more likely to have mixed brain pathologies compared with age-, sex-, education-, and cognition-matched white decedents with AD dementia.
Serum levels of polychlorinated biphenyls in Mexican women and breast cancer risk

The most prevalent female cancer across the world is breast cancer. Current established breast cancer risk factors explain only a fraction of the breast cancer cases diagnosed, and for this reason, other environmental factors have been studied. Exposure to organochlorine compounds has been linked to an increased incidence of breast cancer, although not all data have been consistent. This study was designed to evaluate the relation between polychlorinated biphenyls (PCB) exposure and breast cancer risk in Mexican women. We recruited 140 women from the General Hospital. The cases were 70 newly diagnosed women. We collected environmental and reproductive information by questionnaire. Blood samples were taken for measurement of serum levels of 20 PCB congeners. Risk of breast cancer was found to be positively associated with heavy congeners, age, postmenopausal status, family history of breast cancer and living close to an industrial facility. When PCB were grouped by structure–activity relationships, the risk of breast cancer was positively associated with groups 2b (odds ratio, OR = 1.90, 95% confidence interval, CI, 1.25–2.88), 3 (OR = 1.81, 95% CI 1.08–3.04) and group 4 (OR = 1.57, 95% CI 1.20–2.07). Among postmenopausal women, PCB levels from groups 1a, 2b, and 4 and total PCB were higher in cases, and an association between risk of breast cancer with groups 1a (OR = 7.59, 95% CI 1.1–51.4), 2b (OR = 3.7, 95% CI 1.2–11.2) and 4 (OR = 1.8, 95% CI 1.1–3.1) was found in this group of women. This study showed an association between heavy and potentially estrogenic PCB congeners and breast cancer risk. Copyright © 2011 John Wiley & Sons, Ltd.
Pseudooceanicola lipolyticus sp. nov., a marine alphaproteobacterium, reclassification of Oceanicola flagellatus as Pseudooceanicola flagellatus comb. nov. and emended description of the genus Pseudooceanicola.

A Gram-stain-negative, rod-shaped bacterium, designated 157T, was isolated from seawater collected from the Philippine Sea. Cells of strain 157T grew in medium containing 0.5-10.0 % NaCl (w/v, optimum 3 %), at pH 6.0-8.5 (optimum 7.0) and at 15-40 °C (optimum 30 °C). Tweens 20, 40 and 80 as well as urea were hydrolysed. The 16S rRNA gene sequence of strain 157T had a high sequence similarity with respect to Pseudooceanicola marinus AZO-CT (97.2 %), and exhibited less than 97.0 % sequence similarity to other type strains of the species with validly published names. Phylogenetic analyses revealed that strain 157T fell within a cluster comprising the Pseudooceanicola species and formed a coherent clade with P. marinus AZO-CT and Pseudooceanicola antarcticus Ar-45T. Strain 157T exhibited average nucleotide identity values of 74.5 and 74.9 % to P. marinus LMG 23705T and P. antarcticus Ar-45T, respectively. In silico DNA-DNA hybridization analysis revealed that strain 157T shared 20.2 % DNA relatedness with P. marinus LMG 23705T and 20.6 % with P. antarcticus Ar-45T, respectively. The sole isoprenoid quinone was ubiquinone 10. The major fatty acids were summed feature 8 (C18 : 1ω7c and/or C18 : 1ω6c), C19 : 0 cyclo ω8c, C16 : 0 2-OH and C16 : 0. The major polar lipids were phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, one unidentified aminolipid and one unidentified glycolipid. The DNA G+C content was 64.6 mol%. According to the phylogenetic, chemotaxonomic and phenotypic data, it represents a novel species of the genus Pseudooceanicola, for which the name Pseudooceanicolalipolyticus is proposed. The type strain is 157T (=KCTC 52654T=MCCC 1K03317T). In addition, the description of the genus Pseudooceanicola is emended and Oceanicola flagellatus is reclassified as Pseudooceanicola flagellatus comb. nov., with the type strain DY470T (=CGMCC 1.12664T=LMG 27871T) proposed.
The Impact of Economic Growth on the Environment: Evidence from Environmental Kuznet Curve Analysis in 7 ASEAN Countries

Environmental degradation is one of the issues resulted from the economic development. ASEAN countries are no exception. As a new economic market', economic growth has affected environmental degradation. The basic theory of the relationship between economic growth and environmental degradation was introduced by Grossman and Krueger in 1991 by adapting the Kuznet Curve inequality theory published by Simon Kuznet in 1955. This theory, Environmental Curve Kuznet theory (EKC), posited that there is possibility of economic growth which could pose a positive impact on ecosystem and environmental improvement. This study tries to prove that EKC theory can occur in ASEAN countries. In addition, this study also aims to illustrate the position of turning point of inverted U-curve in ASEAN region and compare the real and estimated value of EKC theory of each country. Several variables used in the study are Gross Domestic Product per capita, added value of industrial sector, and percentage of urban population growth. These variables are used as a reference to prove the influence between economic growth and environmental degradation, as reflected by Carbon Dioxide (CO2) pollution variables. The results of this study shows that all economic variables have a significant impact on CO2 pollution levels. Furthermore, this study proves that there is a turning point where ASEAN countries will enjoy positive results from economic growth on the environment. Nevertheless, not all ASEAN countries are able to pass the point due to the close distance between the real and estimated value of EKC theory that rise annually. Keywords: environmental economics, Kuznet Kurve, Environmental Kuznet Curve, industrialization, urbanization, panel data regression, fixed effect model
Innovation in small-scale aquaculture in Chile

ABSTRACT In light of the current depletion of extractive marine resources and the sustainability issues that have arisen in the aquaculture industry, the small-scale aquaculture sector has emerged as a viable and sustainable alternative for generating income. To integrate the small-scale aquaculture sector into the food value chain, understanding the decision-making process to innovate becomes essential. This paper explores the factors underlying both innovation choices and intensity among small-scale aquaculture producers by utilizing exclusive census data from the small-scale aquaculture sector in Chile. The results indicate that education, secure property rights, internet access, participation in organizations, commercialization methods, government instruments, understanding of credit, and social learning promote innovation decisions. We also find that largest producers innovate in more areas, suggesting a role of size for both technological and non-technological innovations.
Inhibition of DNA-Dependent Protein Kinase Induces Accelerated Senescence in Irradiated Human Cancer Cells

DNA-dependent protein kinase (DNA-PK) plays a pivotal role in the repair of DNA double-strand breaks (DSB) and is centrally involved in regulating cellular radiosensitivity. Here, we identify DNA-PK as a key therapeutic target for augmenting accelerated senescence in irradiated human cancer cells. We find that BEZ235, a novel inhibitor of DNA-PK and phosphoinositide 3-kinase (PI3K)/mTOR, abrogates radiation-induced DSB repair resulting in cellular radiosensitization and growth delay of irradiated tumor xenografts. Importantly, radiation enhancement by BEZ235 coincides with a prominent p53-dependent accelerated senescence phenotype characterized by positive β-galactosidase staining, G2–M cell-cycle arrest, enlarged and flattened cellular morphology, and increased p21 expression and senescence-associated cytokine secretion. Because this senescence response to BEZ235 is accompanied by unrepaired DNA DSBs, we examined whether selective targeting of DNA-PK also induces accelerated senescence in irradiated cells. Significantly, we show that specific pharmacologic inhibition of DNA-PK, but not PI3K or mTORC1, delays DSB repair leading to accelerated senescence after radiation. We additionally show that PRKDC knockdown using siRNA promotes a striking accelerated senescence phenotype in irradiated cells comparable with that of BEZ235. Thus, in the context of radiation treatment, our data indicate that inhibition of DNA-PK is sufficient for the induction of accelerated senescence. These results validate DNA-PK as an important therapeutic target in irradiated cancer cells and establish accelerated senescence as a novel mechanism of radiosensitization induced by DNA-PK blockade. Mol Cancer Res; 9(12); 1696–707. ©2011 AACR.
Self-Synchronized Synchronverters: Inverters Without a Dedicated Synchronization Unit

A synchronverter is an inverter that mimics synchronous generators, which offers a mechanism for power systems to control grid-connected renewable energy and facilitates smart grid integration. Similar to other grid-connected inverters, it needs a dedicated synchronization unit, e.g., a phase-locked loop (PLL), to provide the phase, frequency, and amplitude of the grid voltage as references. In this paper, a radical step is taken to improve the synchronverter as a self-synchronized synchronverter by removing the dedicated synchronization unit. It can automatically synchronize itself with the grid before connection and track the grid frequency after connection. This considerably improves the performance, reduces the complexity, and computational burden of the controller. All the functions of the original synchronverter, such as frequency and voltage regulation, real power, and reactive power control, are maintained. Both simulation and experimental results are presented to validate the control strategy. Experimental results have shown that the proposed control strategy can improve the performance of frequency tracking by more than 65%, the performance of real power control by 83%, and the performance of reactive power control by about 70%.
Cyclic Voltammetry Peaks Due to Deep Level Traps in Si Nanowire Array Electrodes

When metal-assisted chemical etching (MACE) is used to increase the effective surface area of Si electrodes for electrochemical capacitors, it is often found that the cyclic voltammetry characteristics contain anodic and cathodic peaks. We link these peaks to the charging–discharging dynamics of deep level traps within the nanowire system. The trap levels are associated with the use of Ag in the MACE process that can leave minute amounts of Ag residue within the nanowire system to interact with the H2O layer surrounding the nanowires in a room temperature ionic liquid. The influence of the traps can be removed by shifting the Fermi level away from the trap levels via spin-on doping. These results in lower capacitance values but improved charge–discharge cycling behavior. Low-frequency noise measurements proof the presence or absence of these deep level traps.
Complete Plastome Sequence of Ludwigia octovalvis (Onagraceae), a Globally Distributed Wetland Plant

ABSTRACT Here, we present the first plastome of Ludwigia octovalvis (Onagraceae, Myrtales) as well as the first plastome in the subfamily Ludwigioideae. This genome is notable for its contracted inverted repeat regions and an expanded small single-copy region compared to other species in the orders Myrtales and Geraniales.
Wafer scale fabrication of carbon nanotube FETs with embedded poly-gates

One critical factor that determines the feasibility of employing carbon nanotubes as channel materials for post-silicon logic devices is the process compatibility to the current CMOS process flow. We show a wafer-scale integration scheme of carbon nanotube field-effect transistor (CNFET) that is performed by 8″ production tools. High density CNT arrays were transferred on the processed wafer, and high performance CNFET with an excellent subthreshold slope (88 mV /decade) is demonstrated. We further show that the work-function tuning enabled by the conventional gate doping can be achieved in our novel embedded poly-Si gate structure. Approximate Vt change of 0.6V, from n-gate to p-gate, is observed. The Vt shift being smaller than the gate work function difference can be attributed to the Fermi level pinning between poly-Si and high-k interface.
Bioenergetic consequences of catabolic shifts by Lactobacillus plantarum in response to shifts in environmental oxygen and pH in chemostat cultures

Proton motive force (PMF), intracellular end product concentrations, and ATP levels were determined when a steady-state Lactobacillus plantarum 8014 anaerobic chemostat culture was shifted to an aerobic condition or was shifted from pH 5.5 to 7.5. The PMF and intracellular ATP levels increased immediately after the culture was shifted from anaerobic to aerobic conditions. The concentrations of intracellular lactate and acetate, which exported protons that contributed to the proton gradient, changed in the same fashion. The H+/lactate stoichiometry, n, varied from 0.8 to 1.2, and the H+/acetate n value changed from 0.8 to 1.6 at 2 h after the shift to aerobic conditions. The n value for acetate excretion remained elevated at aerobic steady state. When the anaerobic culture was shifted from pH 5.5 to 7.5, intracellular ATP increased 20% immediately even though the PMF decreased 50% as a result of the depletion of the transmembrane proton gradient. The H+/lactate n value changed from 0.7 to 1.8, and n for H+/acetate increased from 0.9 to 1.9 at pH 7.5 steady state. In addition, the H+/acetate stoichiometry was always higher than the n value for H+/lactate; both were higher in alkaline than aerobic conditions, demonstrating that L. plantarum 8014 coexcreted more protons with end products to maintain intracellular pH homeostasis and generate proton gradients under aerobic and alkaline conditions. During the transient to pH 7.5, the n value for H+/acetate approached 3, which would spare one ATP.
The Politics Of A Religious Enclave: Orthodox Jews In Interwar Transylvania, Romania

History in general and the study of religious fundamentalism in particular, as well as the ongoing conflicts between various Muslim groups in the Middle East, teach us not only the importance of religious identity but also about the lengths that those who seek to hold on to a specific identity are prepared to go. This article addresses one minor manifestation of this vast phenomenon. From the mid-nineteenth century onward, Hungarian Jews began to acquire a unique religious and social identity that set them apart from other European Jews. Its single most distinctive feature was the formal separation between Orthodox and Non-Orthodox Jews, almost as if they belonged to two different “Jewish churches. ” For the first and only time in Jewish history, Orthodox Jews were able to administer their own communities in accordance with halachic laws and were no longer forced to compromise with non-Orthodox Jews. Following World War I, Transylvania, formerly a Hungarian district, was annexed to Romania. Consequently, its Jews were cut-off from their Hungarian homeland, which had previously enabled them to establish their own Jewish identity. Reluctant to lose their distinct characteristics, they sought and received governmental permission to establish communities and institutions in accordance with their former lifestyle. This led to the establishment of a religiously and culturally autonomous enclave within which the Jews of Transylvania, many of whom were Orthodox, led their public life differently from all the other Romanian Jews. This article focuses on the development of the separate Orthodox institutions and communities in Transylvania. It surveys the characteristics and inner conflicts of Transylvanian Orthodoxy. It then proceeds to demonstrate how the unique set of circumstances that evolved during the interwar period facilitated the strengthening of Orthodoxy’s
A second monoclinic polymorph of 4-(2-hydroxy-4-methoxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one

The title compound, C19H19N3O3, prepared by condensing 4-aminoantipyrine and 4-methoxy-2-hydroxybenzaldehyde in methanol, is the second monoclinic polymorph of this compound which crystallizes in the space group C2/c. The structure was previously reported [Wang, Zhang, Yan, Zheng & Yang (2007 ▶). Acta Cryst. E63, o1245–o1246] in the space group P21/c. The hydroxyl group is disordered over two positions with occupancies of 0.787 (4) and 0.213 (4). The triply substituted benzene ring and the phenyl ring form dihedral angles of 12.2 (2) and 53.7 (2)°, respectively, with the pyrazolone ring; the corresponding values in the P21/c polymorph are 7.5 (2) and 42.6 (2)°. Intramolecular O—H⋯N and C—H⋯O hydrogen bonds are observed in the major disorder component. Adjacent molecules are linked through intermolecular O—H⋯O hydrogen bonds, forming dimers.