Miracle-dz/UniFAR-FTUs huggingface dataset:
Numerical Simulations of HH 555

We present three-dimensional (3D) gasdynamic simulations of the Herbig Haro object HH 555. HH 555 is a bipolar jet emerging from the tip of an elephant trunk entering the Pelican Nebula from the adjacent molecular cloud. Both beams of HH 555 are curved away from the center of the H II region. This indicates that they are being deflected by a sidewind probably coming from a star located inside the nebula or by the expansion of the nebula itself. HH 555 is most likely an irradiated jet emerging from a highly embedded protostar, which has not yet been detected. In our simulations we vary the incident photon flux, which in one of our models is equal to the flux coming from a star 1 pc away emitting 5 × 1048 ionizing (i.e., with energies above the H Lyman limit) photons per second. An external, plane-parallel flow (a "sidewind") is coming from the same direction as the photoionizing flux. We have made four simulations, decreasing the photon flux by a factor of 10 in each simulation. We discuss the properties of the flow, and we compute Hα emission maps (integrated along lines of sight). We show that the level of the incident photon flux has an important influence on the shape and visibility of the jet. If the flux is very high, it causes a strong evaporation of the neutral clump, producing a photoevaporated wind traveling in the direction opposite to the incident flow. The interaction of the two flows creates a double shock "working surface" around the clump, protecting it and the jet from the external flow. The jet only starts to curve when it penetrates through the working surface.
The impact of e-marketplaces on dyadic buyer-supplier relationships: evidence from the healthcare sector

This study seeks to explore the impact of e‐marketplaces on dyadic buyer‐supplier relationships in the healthcare sector. In particular it seeks to determine if the “move to the middle” hypothesis put forward by Clemons et al. will be supported in this domain. Case studies of four buying organisations in the healthcare sector (hospitals) and two suppliers (medical device companies), representing eight dyadic buyer supplier relationships were undertaken. It was found that the adoption of e‐marketplaces is associated with a reduction in the number of suppliers used by the buying organisations; a deepening of the relationship with the remaining suppliers and an increased “blurring of the boundaries” between the two parties.
A novel neuro-fuzzy controller for autonomous underwater vehicles

Presents a neuro-fuzzy controller for autonomous underwater vehicles (AUVs) of which the dynamics are highly nonlinear, coupled, and time-varying. Modified fuzzy membership function-based neural networks (FMFNN) are used to combine advantages of fuzzy logics and neural networks, such as inference capability and adoption of human operators' fuzzy logics, and universal learning capability with neural networks. With initial fuzzy rules given by a human operator or automatically generated by a controller, the AUV can learn appropriate control parameters without human intervention, taking into account the differences in sensor characteristics in different environments. Internal learning loops and simplified derivatives of unknown systems are used for fast and simple converging algorithms. Compared to other control methods, the proposed FMFNN control algorithm never requires any information on systems, off-line learning procedures, or human intervention to adjust parameters. To show the validity of the proposed algorithm, computer simulation results are presented.
A Selective Refinement Approach for Computing the Distance Functions of Curves

We present an adaptive signed distance transform algorithm for curves in the plane. A hierarchy of bounding boxes is required for the input curves. We demonstrate the algorithm on the isocontours of a turbulence simulation. The algorithm provides guaranteed error bounds with a selective refinement approach. The domain over which the signed distance function is desired is adaptively triangulated and piecewise discontinuous linear approximations are constructed within each triangle. The resulting transform performs work only were requested and does not rely on a preset sampling rate or other constraints.
Alleles 308A and 238A in the Tumor Necrosis Factor Alpha Gene Promoter Do Not Increase the Risk of Severe Malaria in Children with Plasmodium falciparum Infection in Mali

ABSTRACT The hypothesis that tumor necrosis factor (TNF) aggravates malaria in children is supported by observations that TNF polymorphisms and high TNF levels have been associated with cerebral malaria. Nevertheless, severe malaria was not associated with polymorphisms located at positions −308A and −238A in the TNF alpha gene promoter or with a high TNF level in plasma in children from Bamako, Mali.
On-board satellite "split TCP" proxy

Several satellite systems currently in operation or under development claim to support broadband Internet applications. In these scenarios, transmission control protocol (TCP) plays a critical role. Unfortunately, when used with satellite links, TCP suffers from a number of well-known performance problems, especially for higher data rates and high altitude satellites with longer delays. In response to these difficulties, the satellite and Internet research communities have developed a large gamut of solutions ranging from architectural modifications to changes in the TCP protocol. Among these, one approach requiring minimal modifications involves splitting the TCP connection in two or more segments with one segment connecting terrestrial nodes across the satellite network. In this paper, we consider an evolution of this idea: placing a TCP proxy on board the satellite that further subdivides the end-to-end connection into separate TCP connections between ground and space. We focus upon the efficient use of buffer resources on board the satellite, while at the same time enhancing TCP performance. We evaluate two TCP protocol versions, TCP NewReno and TCP Westwood. We consider various geosynchronous earth orbit satellite scenarios, with and without the split proxy, and with different channel error conditions (random errors, shadowing, etc.). Using simulation, we show that an on-board proxy provides a number of distinct advantages and can enhance throughput up to threefold for both TCP New Reno and TCP Westwood, in some scenarios, with relatively modest on-board buffering requirements. The main contributions of this paper are: the on-board split proxy concept, the buffer management strategy, the use of a realistic "urban shadowing" model in the evaluation, and the extensive comparison of the recently announced TCP Westwood with the traditional TCP New Reno.
Predictive codes of interoception, emotion, and the self

Interoception is the ability to perceive and integrate physiological signals from within the body. It is closely related to the autonomic system and is a key component in the generation of affective states and abstract representations of the self (Critchley et al., 2004; Ainley and Tsakiris, 2013). Seth proposes a predictive coding (PC) model of interoception that involves a free-energy based explanation of emotion awareness and selfhood. In this model, emotions, and in turn the sense of self, rely on predictions of the causes of interoceptive signals. Within this framework, the interoceptive system minimizes free-energy, or the discrepancy between predictions and interoceptive signals. Free-energy can be minimized either by updating predictions about the causes of the sensory signals (perceptual updating), or by acting to change autonomic states such that bodily states are more predictable (active inference).
An Efficient Privacy-Preserving Outsourced Computation over Public Data

In this paper, we propose a new efficient privacy-preserving outsourced computation framework over public data, called EPOC. EPOC allows a user to outsource the computation of a function over multi-dimensional public data to the cloud while protecting the privacy of the function and its output. Specifically, we introduce three types of EPOC in order to tradeoff different levels of privacy protection and performance. We present a new cryptosystem called Switchable Homomorphic Encryption with Partially Decryption (SHED) as the core cryptographic primitive for EPOC. We introduce two coding techniques, called message pre-coding technique and message extending and coding technique respectively, for messages encrypted under a composite order group. Furthermore, we propose a Secure Exponent Calculation Protocol with Public Base (SEPB), which serves as the core sub-protocol in EPOC. Detailed security analysis shows that the proposed EPOC achieves the goal of outsourcing computation of a private function over public data without privacy leakage to unauthorized parties. In addition, performance evaluations via extensive simulations demonstrate that EPOC is efficient in both computation and communications.
In situ degradation kinetic of Andropogon gayanus grass silages harvested at three stages of maturity

Maturity is considered the primary factor affecting the nutritive value of forages. The aim of this study was to evaluate and compare dry matter (DM), crude protein (CP) and neutral detergent fiber (NDF) ruminal degradation kinetics of Andropogon gayanus grass silages harvested at three stages of maturity (56, 84 and 112 d). Dried and ground silage samples (5 mm) were incubated in nylon bags inside the rumen for 0, 6, 12, 24, 48, 72 and 96 h to estimate the kinetics of ruminal DM, CP and NDF degradation. The ruminal kinetic parameters of the silages from each treatment (56, 84 and 112 d of regrowth) in each animal (5 cows) were determined by the model: y = a + b(1 − e). The parameters generated by the model were analyzed as randomized block design, with grass regrowth age as the fixed effect and animal the as random effect (blocks). The grass silage ensiled with 56 days of regrowth had the highest (P<0.05) effective degradability of DM and NDF calculated for fractional rate of particulate passage of 2%/h. All silages had low CP soluble fraction (<25.4%) and effective degradability calculated for fractional rate of particulate passage of 2%/h (<40.1%). A greater (P<0.05) NDF lag time was observed for the silages ensiled with 84 and 112d compared to the silage produced with 56d of regrowth. The ruminal degradation kinetics of Andropogon gayanus grass silages showed that the grass ensiled with 56 days of regrowth had higher nutritional value.
Transformation of leucine and rifampin traits in Neisseria gonorrhoeae with deoxyribonucleic acid from homologous and heterologous origins

A leucine-requiring, rifampin-sensitive strain of Neisseria gonorrhoeae was transformed to a leucine-nonrequiring, rifampin-resistant phenotype with deoxyribonucleic acid (DNA) obtained from both N. meningitidis and N. gonorrhoeae. The transforming efficiency of the meningococcal DNA was about 10- to 100-fold less than that of the homologous gonococcal DNA. A chemically defined medium that would support growth of most gonococcal isolates was used as a complete medium. A minimal medium was used for selection of Leu+ transformants. N-methyl-N'-nitro-N-nitrosoguanidine was used as a mutagen for isolating leucine prototrophs from leucine-requiring isolates of N. gonorrohoeae.
510(k) SUBSTANTIAL EQUIVALENCE DETERMINATION DECISION SUMMARY ASSAY AND INSTRUMENT COM BINATION TEMPLATE

A. 510(k) Number: K080931 B. Purpose for Submission: To determine substantial equivalence of the device for the detection of C. difficile A & B in stool specimens. This an Intended Use claim extension to K072138 C. Measurand: C. difficile toxins A & B D. Type of Test: Qualitative automated test on the VIDAS instrument using the enzyme linked fluorescent assay (ELFA) technique E. Applicant: bioMerieux Inc. F. Proprietary and Established Names: VIDAS C. difficile Toxin A & B (CDAB) assay G. Regulatory Information: 1. Regulation section: 21 CFR 866.2660, reagents, Clostridium difficile toxin 2. Classification: Class 1 3. Product code: LLH 4. Panel:
High expression of follicle stimulating hormone receptor in testicular tissue of idiopathic azoospermic patients with severe spermatogenic defects

Background Follicle stimulating hormone is necessary for normal reproduction in men. The biochemical actions of follicle stimulating hormone result from binding to the follicle stimulating hormone receptor in the plasma membrane of Sertoli cells. Here, we investigated the expression of the follicle stimulating hormone receptor in different testicular histological phenotypes of patients with idiopathic azoospermia. Methods Fifty‐seven cases of idiopathic azoospermia were classified into three groups according to the results of testicular biopsy: patients with hypospermatogenesis, patients with maturation arrest, and patients with Sertoli cell‐only syndrome. Thirteen azoospermic patients identified by testicular biopsy as being capable of completing spermatogenesis acted as the control group. Immunohistochemistry and real‐time quantitative reverse‐transcriptase polymerase chain reaction were performed in each case, and the serum hormone level was also measured in all patients. Results The serum follicle stimulating hormone level in patients with Sertoli cell‐only syndrome was significantly higher than in patients with hypospermatogenesis, maturation arrest, and complete spermatogenesis (P<0.01). The serum follicle stimulating hormone level in patients with maturation arrest was significantly higher than in patients with hypospermatogenesis and complete spermatogenesis (P<0.05). There was no difference in serum follicle stimulating hormone levels in patients with hypospermatogenesis and complete spermatogenesis. The follicle stimulating hormone receptor expression level of testicular samples with Sertoli cell‐only syndrome was significantly higher than in those with hypospermatogenesis, maturation arrest, and complete spermatogenesis (P<0.05), but no significant difference was observed among hypospermatogenesis, maturation arrest, and complete spermatogenesis testicular samples. Conclusions Different serum follicle stimulating hormone levels and follicle stimulating hormone receptor expression were found in the different testicular histology phenotypes in azoospermic patients. Differential follicle stimulating hormone receptor expression in testicular tissue of patients with idiopathic azoospermia may be associated with the degree of spermatogenesis.
Antidepressant drug paroxetine blocks the open pore of Kv3.1 potassium channel

In patients with epilepsy, depression is a common comorbidity but difficult to be treated because many antidepressants cause pro-convulsive effects. Thus, it is important to identify the risk of seizures associated with antidepressants. To determine whether paroxetine, a very potent selective serotonin reuptake inhibitor (SSRI), interacts with ion channels that modulate neuronal excitability, we examined the effects of paroxetine on Kv3.1 potassium channels, which contribute to highfrequency firing of interneurons, using the whole-cell patch-clamp technique. Kv3.1 channels were cloned from rat neurons and expressed in Chinese hamster ovary cells. Paroxetine reversibly reduced the amplitude of Kv3.1 current, with an IC50 value of 9.43 µM and a Hill coefficient of 1.43, and also accelerated the decay of Kv3.1 current. The paroxetine-induced inhibition of Kv3.1 channels was voltage-dependent even when the channels were fully open. The binding (k+1) and unbinding (k−1) rate constants for the paroxetine effect were 4.5 µM−1s−1 and 35.8 s−1, respectively, yielding a calculated KD value of 7.9 µM. The analyses of Kv3.1 tail current indicated that paroxetine did not affect ion selectivity and slowed its deactivation time course, resulting in a tail crossover phenomenon. Paroxetine inhibited Kv3.1 channels in a usedependent manner. Taken together, these results suggest that paroxetine blocks the open state of Kv3.1 channels. Given the role of Kv3.1 in fast spiking of interneurons, our data imply that the blockade of Kv3.1 by paroxetine might elevate epileptic activity of neural networks by interfering with repetitive firing of inhibitory neurons.
Models of space in a mixed-reality system

In this paper we discuss the use of models of space in the building of mixed-reality systems. By model of space we mean a geometric or symbolic description associated with a physical space. We outline several types of model that exist, how they are surveyed and authored, how they are represented to the users and how they are supported by middleware and sensors. We show that systems often contain numerous models of space and we discuss the issues in maintaining or reifying assumptions about transformations between models. We illustrate these ideas by describing the implementation of a collaborative mixed-reality system that allows users to experience a museum in three modalities: physically colocated visitor with personal digital assistant guide, virtual reality visitor and Web visitor.
Control of brain patterning by Engrailed paracrine transfer: a new function of the Pbx interaction domain

Homeoproteins of the Engrailed family are involved in the patterning of mesencephalic boundaries through a mechanism classically ascribed to their transcriptional functions. In light of recent reports on the paracrine activity of homeoproteins, including Engrailed, we asked whether Engrailed intercellular transfer was also involved in brain patterning and boundary formation. Using time-controlled activation of Engrailed combined with tools that block its transfer, we show that the positioning of the diencephalic-mesencephalic boundary (DMB) requires Engrailed paracrine activity. Both zebrafish Eng2a and Eng2b are competent for intercellular transfer in vivo, but only extracellular endogenous Eng2b, and not Eng2a, participates in DMB positioning. In addition, disruption of the Pbx-interacting motif in Engrailed, known to strongly reduce the gain-of-function phenotype, also downregulates Engrailed transfer, thus revealing an unsuspected participation of the Pbx interaction domain in this pathway. SUMMARY: The paracrine activity of Engrailed, together with its PBX-interacting hexapeptide motif, is involved in boundary formation during brain development in zebrafish.
The Quest for Characterizing Exosomes: Circulating Nano-Sized Vesicles

Research on secreted membrane vesicles, in particular exosomes, is a very exciting field. Exosomes are 50-100 nm particles secreted into the extracellular environment by a wide range of normal mammalian cells. Exosomes are formed by exocytosis through an inward budding of the cell membrane [1] and possess cell type-specific lipid-bilayer membrane (containing cytosolic proteins, m-RNA, mi-RNA). Although their physiological functions are yet unclear, exosomes are known to play a role in specialized functions such as cell antigen presentation [2], intercellular communication [3], shuttling m-RNA/ mi-RNA [4] or infectious agents [5].
Five-year review of an international clinical research-training program

The exponential increase in clinical research has profoundly changed medical sciences. Evidence that has accumulated in the past three decades from clinical trials has led to the proposal that clinical care should not be based solely on clinical expertise and patient values, and should integrate robust data from systematic research. As a consequence, clinical research has become more complex and methods have become more rigorous, and evidence is usually not easily translated into clinical practice. Therefore, the instruction of clinical research methods for scientists and clinicians must adapt to this new reality. To address this challenge, a global distance-learning clinical research-training program was developed, based on collaborative learning, the pedagogical goal of which was to develop critical thinking skills in clinical research. We describe and analyze the challenges and possible solutions of this course after 5 years of experience (2008–2012) with this program. Through evaluation by students and faculty, we identified and reviewed the following challenges of our program: 1) student engagement and motivation, 2) impact of heterogeneous audience on learning, 3) learning in large groups, 4) enhancing group learning, 5) enhancing social presence, 6) dropouts, 7) quality control, and 8) course management. We discuss these issues and potential alternatives with regard to our research and background.
Tracking of extended objects and group targets using random matrices — a new approach

The task of tracking extended objects or (partly) unresolvable group targets raises new challenges for both data association and track maintenance. Extended objects may give rise to more than one detection per opportunity where the scattering centers may vary from scan to scan. On the other end, group targets (i. e., a number of closely spaced targets moving in a coordinated fashion) often will not cause as many detections as there are individual targets in the group due to limited sensor resolution capabilities. In both cases, tracking and data association under the one target-one detection assumption are no longer applicable. This paper deals with the problem of maintaining a track for an extended object or group target with varying number of detections. Herein, object extension is represented by a random symmetric positive definite matrix. A recently published Bayesian approach to tackling this problem is analyzed and discussed. From there, a new approach is derived that is expected to overcome some of the weaknesses the Bayesian approach suffers from in certain applications.
Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls.

OBJECTIVE To study the occurrence of bronchial obstructive symptoms and immunoglobulin (Ig) E antibodies after respiratory syncytial virus (RSV) bronchiolitis in infancy. Previous studies of this subject have mostly been retrospective or without controls, or the controls have not been followed prospectively. DESIGN This was a prospective cohort study with matched controls. PARTICIPANTS Forty-seven infants had experienced RSV bronchiolitis severe enough to cause hospitalization at a mean age of 3 1/2 months. For each child with RSV infection, two controls were acquired from the local Child Health Center and matched for date of birth, sex, and residence. Only one control was obtained for one RSV child, and the control group thus contained 93 children. METHODS All the children underwent two follow-up examinations, the first one at a mean age of 1 year and the second at a mean age of 3 years. At the first follow-up, a skin-prick test against egg white was performed, and serum IgG antibodies against RSV were measured. At the second follow-up, serum IgE antibodies were measured using screening tests for common food and inhalant antibodies, and skin-prick tests against egg white, cat, birch, and mite allergen were performed. Hereditary and environmental factors (passive smoking, indoor furred animals) and duration of breast-feeding were recorded. RESULTS At the first follow-up, 89% in the RSV group and 27% in the control group had IgG antibodies against RSV (P < .001). At the second follow-up, asthma, defined as three episodes of bronchial obstruction verified by a physician, was found in 11 of 47 children (23%) in the RSV group and in 1 of 93 children (1%) in the control group (P < .001). A positive test for IgE antibodies was noted in 14 of 44 (32%) RSV children and in 8 of 92 (9%) children in the control group (P = .002). An analysis of risk factors for the development of asthma and IgE antibodies on the whole group of 140 children showed that RSV bronchiolitis was the most important risk factor, and a family history of atopy or asthma further increased the risk. CONCLUSIONS Respiratory syncytial virus bronchiolitis during the first year of life apparently is an important risk factor for the development of asthma and sensitization to common allergens during the subsequent 2 years, particularly in children with hereditary for atopy/asthma.