Miracle-dz/UniFAR-FTUs huggingface dataset:
A discussion of cultivating undergraduate talents of tourism management based on the CDIO mode

This paper ,based on the “knowledge ,ability and quality”,establishes knowledge integration modular curriculu m system. For the first time in Henan Province ,this paper creates a professional ability standard module for tourism management ,establishes the diversified teaching method which p ossesses the characteristics of teaching process integration. To enhance the learning assessment met hod of students’self-learning ability ,and to explore the effectiveness of the change of teacher’s role from the perspective of improving teachers’ability of CD IO,it will be beneficial to improve the quality of tourism manage ment.
The fetal safety of cetirizine: An observational cohort study and meta-analysis

Abstract Cetirizine, a second-generation antihistamine, is an active metabolite of hydroxyzine used in the treatment of allergies, but the data on fetal safety are inconclusive. Pregnant women who were counselled by the ‘Motherisk Program’ regarding cetirizine exposure were enrolled in a cohort study and compared with pregnant women counselled for non-teratogenic exposures. The objective was to measure the rate of adverse pregnancy outcomes. Subsequently, we also conducted a meta-analysis of cohort studies that examined the pregnancy outcomes of women exposed to hydroxyzine or cetirizine during pregnancy. In the cohort study, there were no significant differences in the rates of major malformations between the cetirizine exposed and comparison group. In the meta-analysis, cetirizine was not associated with increased teratogenic risk. In contrast, a meta-analysis of cetirizine and hydroxyzine studies showed a marginal association with major malformations. Cetirizine is not associated with a clinically important increase in risk of adverse fetal outcomes.
VLSI Implementation of BCH Error Correction for Multilevel Cell NAND Flash Memory

Bit-error correction is crucial for realizing cost-effective and reliable NAND Flash-memory-based storage systems. In this paper, low-power and high-throughput error-correction circuits have been developed for multilevel cell (MLC) nand Flash memories. The developed circuits employ the Bose-Chaudhuri-Hocquenghem code to correct multiple random bit errors. The error-correcting codes for them are designed based on the bit-error characteristics of MLC NAND Flash memories for solid-state drives. To trade the code rate, circuit complexity, and power consumption, three error-correcting architectures, named as whole-page, sector-pipelined, and multistrip ones, are proposed. The VLSI design applies both algorithmic and architectural-level optimizations that include parallel algorithm transformation, resource sharing, and time multiplexing. The chip area, power consumption, and throughput results for these three architectures are presented.
Felix : Scaling up Global Statistical Information Extraction Using an Operator-based Approach

To support the next generation of sophisticated information extraction (IE) applications, several researchers have proposed frameworks that integrate SQL-like languages with statistical reasoning. While these frameworks demonstrate impressive quality on small IE tasks, they currently do not scale to enterprise-sized tasks. To enable the next generation of IE, a promising approach is to improve the scalability and performance of such statistical frameworks. Our technical observation is that many IE subtasks, such as coreference resolution or classification, can be solved by specialized algorithms that achieve both high quality and high performance. In contrast, current general-purpose statistical inference approaches are oblivious to these subtasks and so use a single algorithm independent of the subtask that they are performing. We present Felix, in which programs are expressed in a general statistical inference language (called Markov logic). Felix first breaks the program into a handful of subtasks, which can then be executed using predefined operators, i.e., statistical algorithms. A key challenge Felix faces is to decide whether or not to materialize intermediate results from the operators. To attack this challenge, Felix uses a cost-based approach that relies on the RDBMS optimizer. Using all of our techniques, we show that Felix efficiently processes global IE programs on large real-world datasets while prior approaches crash or take days. Felix, in turn, is able to execute programs that achieve higher quality than state-of-the-art IE approaches on three real-world datasets.
Rechtsdatenbanken und Relevanzsortierung

Rechtsdatenbanken ermoglichen ihren Benutzer/innen eine elektronische juristische Recherche uber eine immer grosere Menge von Normen-, Judikatur- sowie Fachliteraturdokumenten. Errungenschaften von Rechtsdatenbanken im Vergleich zu klassischen Print-Recherchen stehen dabei Herausforderungen gegenuber welche aus der steigenden abrufbaren Materialfulle, der Unterstutzungsbedurftigkeit der Benutzer/innen, Technologiedefiziten der Datenbanken sowie Eigenschaften von Volltextspeicherung und Volltextsuche resultieren. Die vorliegende Arbeit unterzieht zunachst Errungenschaften wie Herausforderungen - unter besonderer Berucksichtigung der Besonderheiten und Erfordernisse juristischer Recherchen - einer eingehenden Analyse. Nutzung und Weiterentwicklung von Relevanzsortierungen werden als zentrales Handlungsfeld fur notwendige Weiterentwicklungen von Rechtsdatenbanken identifiziert. Die Grundfrage der Arbeit lautet dann, in welcher Form Rechtsdatenbanken Technologien des Relevance Ranking, also der Trefferlistensortierung nach absteigender Relevanzwahrscheinlichkeit, einsetzen sollen. Das Ergebnis der Arbeit lautet, dass Rechtsdatenbanken Relevanzsortierungen einsetzen mussen um ihre Aufgaben auch in Zukunft bestmoglich erfullen zu konnen, und zwar in einer Fachgebiet-spezifischen Auspragung. Konkrete Ranking-Faktoren fur Rechtsdatenbanken werden evaluiert und vorgeschlagen, und Uberlegungen zur geeigneten Kombination von Ranking-Faktoren sowie begleitenden Masnahmen angestellt.
A Two-Stage Broadband Fully Integrated CMOS Linear Power Amplifier for LTE Applications

This brief presents the implementation and measurement results of a CMOS broadband linear power amplifier (PA) for long-term evolution (LTE) applications. Interstage matching considering the main's source and the driver's load impedances is analyzed for broadband linear output power. The proposed PA is fabricated in standard 0.11-μm RF CMOS technology. The PA achieves linear output power of 27.9-27.3 dBm and power-added efficiency of 33%-26.1% under an adjacent channel power ratio (ACLRE-UTRA) of -30 dBc for an LTE 16-QAM 10-MHz bandwidth signal with a carrier frequency range of 1.8-2.3 GHz.
Knockdown of long non‐coding RNA ANRIL inhibits proliferation, migration, and invasion but promotes apoptosis of human glioma cells by upregulation of miR‐34a

Gliomas are the most common types of primary central nervous system malignancy found in adults. Long non‐coding RNA antisense non‐coding RNA in the INK4 locus (ANRIL) variants are associated with glioma and miR‐34a is markedly downregulated in U251 glioma cells. The 3′‐untranslated region (3′UTR) of silent information regulator 1 (Sirt1) contains a conserved site that is targeted directly by miR‐34a. Therefore, in this study, we investigated the roles of ANRIL, miR‐34a, and Sirt1 in glioma and their potential interactions. Firstly, expression of ANRIL in normal glia cells and five glioma cell lines was measured. Then, effects of ANRIL suppression on cell proliferation, apoptosis, migration and invasion of U251 cells as well as expression of miR‐34a were assessed. Meanwhile, effects of miR‐34a on U251 cells silencing ANRIL were tested. Whether Sirt1 is a target of miR‐34a was verified, followed by estimating the role of Sirt1 overexpression in U251 cells overexpressing miR‐34a. Finally, the involved signaling pathways were assessed. ANRIL was upregulated in glioma cells and its suppression inhibited cell proliferation, migration and invasion but promoted cell apoptosis. ANRIL acted as a sponge of miR‐34a, and Sirt1 is a target of miR‐34a. Then, Sirt1 was proved to function through activation of the PI3K/AKT and mTOR signaling pathways. In conclusion, ANRIL was upregulated in glioma, and its inhibition could repress cell proliferation, migration and invasion but inhibit cell apoptosis through miR‐34a‐mediated downregulation of Sirt1, involving the inactivation of the PI3K/AKT and mTOR pathways.
Anatomical characterization of bombesin receptor subtype‐3 mRNA expression in the rodent central nervous system

Bombesin receptor subtype‐3 (BRS‐3) is an orphan G‐protein‐coupled receptor (GPCR) involved in the regulation of energy homeostasis. Mice deficient in BRS‐3 develop late‐onset mild obesity with metabolic defects, while synthetic agonists activating BRS‐3 show antiobesity profiles by inhibiting food intake and increasing metabolic rate in rodent models. The molecular mechanisms and the neural circuits responsible for these effects, however, remain elusive and demand better characterization. We report here a comprehensive mapping of BRS‐3 mRNA in the rat and mouse brain through in situ hybridization. Furthermore, to investigate the neurochemical characteristics of the BRS‐3‐expressing neurons, double in situ hybridization was performed to determine whether BRS‐3 colocalizes with other neurotransmitters or neuropeptides. Many, but not all, of the BRS‐3‐expressing neurons were found to be glutamatergic, while few were found to be cholinergic or GABAergic. BRS‐3‐containing neurons do not express some of the well‐characterized neuropeptides, such as neuropeptide Y (NPY), proopiomelanocortin (POMC), orexin/hypocretin, melanin‐concentrating hormone (MCH), thyrotropin‐releasing hormone (TRH), gonadotropin‐releasing hormone (GnRH), and kisspeptin. Interestingly, BRS‐3 mRNA was found to partially colocalize with corticotropin‐releasing factor (CRF) and growth hormone‐releasing hormone (GHRH), suggesting novel interactions of BRS‐3 with stress‐ and growth‐related endocrine systems. Our study provides important information for evaluating BRS‐3 as a potential therapeutic target for the treatment of obesity. J. Comp. Neurol. 521:1020–1039, 2013. © 2012 Wiley Periodicals, Inc.
Accuracy evaluation of a new stereophotogrammetry-based functional method for joint kinematic analysis in biomechanics

The human joint kinematics is an interesting topic in biomechanics and turns to be useful for the analysis of human movement in several fields. A crucial issue regards the assessment of joint parameters, like axes and centers of rotation, due to the direct influence on human motion patterns. A proper accuracy in the estimation of these parameters is hence required. On the whole, stereophotogrammetry-based predictive methods and, as an alternative, functional ones can be used to this end. This article presents a new functional algorithm for the assessment of knee joint parameters, based on a polycentric hinge model for the knee flexion–extension. The proposed algorithm is discussed, identifying its fields of application and its limits. The techniques for estimating the joint parameters from the metrological point of view are analyzed, so as to lay the groundwork for enhancing and eventually replacing predictive methods, currently used in the laboratories of human movement analysis. This article also presents an assessment of the accuracy associated with the whole process of measurement and joint parameters estimation. To this end, the presented functional method is tested through both computer simulations and a series of experimental laboratory tests in which swing motions were imposed to a polycentric mechanical analogue and a stereophotogrammetric system was used to record them.
Establishment of a Functional Ovine Fetoplacental Artery Endothelial Cell Line with a Prolonged Life Span1

Abstract To study mechanisms governing fetoplacental vascular function, we have established a primary ovine fetoplacental artery endothelial (OFPAE) cell line. These OFPAE cells produce nitric oxide (NO), proliferate, and migrate in response to fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor (VEGF). To overcome the senescence crisis that this primary OFPAE cell line will eventually enter, we attempted to establish a functional OFPAE cell line with a prolonged life span by transfecting cells with plasmids containing a neomycin resistance gene and a simian virus 40 gene (SV40) expressing large T (T) and small t (t) antigens. The OFPAE cells at passage 8 were transfected. After neomycin selection, the surviving OFPAE (designated SV40 OFPAE) cells were expanded up to passage 80. Up to passage 30, these SV40 OFPAE cells maintained a morphology similar to untransfected OFPAE cells. Expression of T and t antigens in SV40 OFPAE cells was confirmed by immunocytochemistry. These SV40 OFPAE cells exhibited positive uptake of acetylated low-density lipoprotein (Ac-LDL) and positive staining for NO synthase 3 (NOS3) and formed capillary-like tube structures on Matrigel. Up to passages 20–23, these SV40 OFPAE cells proliferated (P < 0.05) and produced (P < 0.05) NO in response to both FGF2 and VEGF. Moreover, this cell proliferation stimulated by FGF2 and VEGF was dose-dependently inhibited (P < 0.05) by PD98059 (a selective mitogen-activated protein kinase 1 and 2 [MAP2K1/2, also termed MEK1/2] inhibitor) or by LY294002 (a selective phosphoinositide 3-kinase [PI3K] inhibitor). These data indicate that SV40 OFPAE cells, at least at passage 23, retain endothelial phenotypes and functions similar to their parental, untransfected OFPAE cells. Thus, a functional OFPAE cell line with an extended life span has been successfully established, potentially providing a valuable cell model for studying fetoplacental endothelial function.
Adherence to physical exercise recommendations in people over 65--the SNAC-Kungsholmen study.

BACKGROUND There is limited knowledge regarding to what extent the older population meet the recommendations of physical exercise, especially fitness-enhancing exercise. This study assessed participation in health- and fitness-enhancing exercises in people aged >65, and explored to what extent the possible differences in meeting current recommendations differs by age, gender and education. METHODS The study population was derived from the Swedish National study on Aging and Care, and consisted of a random sample of 2593 subjects, aged 65+ years. Participation in health- and fitness-enhancing exercise according to the WHO and the American College of Sports Medicine's recommendations in relation to age, gender and education was evaluated using multinomial logistic regression adjusted for health indicators and physical performance. RESULTS According to the recommendations, 46% of the participants fulfilled the criteria for health-enhancing and 16% for fitness-enhancing exercises. Independent of health indicators and physical performance, women <80 years of age were less likely than men to participate in fitness-enhancing exercise, but they participated more in health-enhancing exercise. In the advanced age group (80+ years), women were less likely to participate both in fitness- and health-enhancing exercise. Advanced age and low education were negatively related to participation in both health- and fitness-enhancing exercise independent of health indicators, but the association was not observed among people with fast walking speed. CONCLUSION Promoting physical exercise and encouraging participation among older adults with lower education, especially among those with initial functional decline, may help to reduce adverse health outcomes.
Ianus : Guaranteeing High Performance in Solid-State Drives

Solid-state drives are becoming increasingly popular in enterprise storage systems, playing the role of large caches and permanent storage. Although SSDs provide faster random access than hard-drives, their performance under read/write workloads is highly variable to the point that it becomes worse than that of hard-drives (e.g., taking 100ms for a single read). Many systems with read/write workloads have low latency requirements, or require predictable performance and guarantees. In such cases SSD performance variability becomes a problem for both predictability and raw performance. First, we show how to provide tight throughput guarantees to multiple clients sharing the same solid-state drive storage. Second, we introduce and evaluate Ianus, a design based on redundancy, which achieves high performance, low latency and stable read throughput, as well as fault-tolerance, making it an alternative RAID-like design for solid-state drives. Finally, by combining the two solutions we provide QoS while maintaining high performance.
Teaching and Learning Auslan via Immersion Methods: A Report for the Queensland Department of Education, Training and the Arts

Teaching and Learning Auslan via Immersion Methods: A Report for the Queensland Department of Education, Training and the Arts Summary The following issues are canvassed in the Report: 剗hat is bilingualism and how are immersion approaches to learning a second language embedded within such a context? 剆eatures of effective immersion programs within the context of DETA requirements 剔he nature of sign languages (especially Auslan) and their role in the Deaf community 剔ypes and uses of signed communication in education 剓ome assumptions about the context of DETA participants: including limited transfers from other language learning experiences, use of immersion opportunities, curriculum and pedagogical adaptations 剁ssessment of Auslan proficiency 剐rograms offered by Griffith University and their methods of delivery 剒ecommended content of DETA program/s 剓ources of information used, references and resources identified
Prolonged food deprivation increases mRNA expression of deiodinase 1 and 2, and thyroid hormone receptor β-1 in a fasting-adapted mammal

SUMMARY Food deprivation in mammals is typically associated with reduced thyroid hormone (TH) concentrations and deiodinase content and activity to suppress metabolism. However, in prolonged-fasted, metabolically active elephant seal pups, TH levels are maintained, if not elevated. The functional relevance of this apparent paradox is unknown and demonstrates variability in the regulation of TH levels, metabolism and function in food-deprived mammals. To address our hypothesis that cellular TH-mediated activity is upregulated with fasting duration, we quantified the mRNA expression and protein content of adipose and muscle deiodinase type I (DI1) and type II (DI2), and TH receptor beta-1 (THrβ-1) after 1, 3 and 7 weeks of fasting in northern elephant seal pups (N=5–7 per week). Fasting did not decrease the concentrations of plasma thyroid stimulating hormone, total triiodothyronine (tT3), free T3, total thyroxine (tT4) or free T4, suggesting that the hypothalamic–pituitary–thyroid axis is not suppressed, but rather maintained during fasting. Mean mRNA expression of adipose DI1 and DI2 increased threefold and fourfold, respectively, and 20- and 30-fold, respectively, in muscle. With the exception of adipose DI1, protein expression of adipose DI2 and muscle DI1 and DI2 increased twofold to fourfold. Fasting also increased adipose (fivefold) and muscle (fourfold) THrβ-1 mRNA expression, suggesting that the mechanisms mediating cellular TH activity are upregulated with prolonged fasting. The data demonstrate a unique, atypical mechanism of TH activity and regulation in mammals adapted to prolonged food deprivation in which the potential responsiveness of peripheral tissues and cellular TH activity are increased, which may contribute to their lipid-based metabolism.
A Snapshot of Functional Genetic Studies in Medicago truncatula

In the current context of food security, increase of plant protein production in a sustainable manner represents one of the major challenges of agronomic research, which could be partially resolved by increased cultivation of legume crops. Medicago truncatula is now a well-established model for legume genomic and genetic studies. With the establishment of genomics tools and mutant populations in M. truncatula, it has become an important resource to answer some of the basic biological questions related to plant development and stress tolerance. This review has an objective to overview a decade of genetic studies in this model plant from generation of mutant populations to nowadays. To date, the three biological fields, which have been extensively studied in M. truncatula, are the symbiotic nitrogen fixation, the seed development, and the abiotic stress tolerance, due to their significant agronomic impacts. In this review, we summarize functional genetic studies related to these three major biological fields. We integrated analyses of a nearly exhaustive list of genes into their biological contexts in order to provide an overview of the forefront research advances in this important legume model plant.
Streptococcus caviae sp. nov., isolated from guinea pig faecal samples.

A novel cellobiose-degrading and lactate-producing bacterium, strain Cavy grass 6T, was isolated from faecal samples of guinea pigs (Cavia porcellus). Cells of the strain were ovalshaped, non-motile, non-spore-forming, Gram-stain-positive and facultatively anaerobic. The strain gr at 25-40 °C (optimum 37 °C) and pH 4.5-9.5 (optimum 8.0). Phylogenetic analysis based on 16S rRNA gene sequences showed that strain Cavy grass 6T belongs to the genus Streptococcus with its closest relative being Streptococcus devriesei CCUG 47155T with only 96.5 % similarity. Comparing strain Cavy grass 6T and Streptococcus devriesei CCUG 47155T, average nucleotide identity and level of digital DNA-DNA hybridization dDDH were only 86.9 and 33.3 %, respectively. Housekeeping genes groEL and gyrA were different between strain Cavy grass 6T and other streptococci. The G+C content of strain Cavy grass 6T was 42.6±0.3 mol%. The major (>10 %) cellular fatty acids of strain Cavy grass 6T were C16:0, C20 : 1ω9c and summed feature 8 (C18 : 1ω7c and/or C18 : 1ω6c). Strain Cavy grass 6T ferment a range of plant mono- and disaccharides as well as polymeric carbohydrates, including cellobiose, dulcitol, d-glucose, maltose, raffinose, sucrose, l-sorbose, trehalose, inulin and dried grass extract, to lactate, formate, acetate and ethanol. Based on phylogenetic and physiological characteristics, Cavy grass 6T can be distinguished from other members of the genus Streptococcus. Therefore, a novel species of the genus Streptococcus, family Streptococcaceae, order Lactobacillales is proposed, Streptococcuscaviae sp. nov. (type strain Cavy grass 6T=TISTR 2371T=DSM 102819T).
An Approach to XML Information Retrieval in Distributed Systems

Abstract Modern search engines are quite successful in finding relevant documents by using Information Retrieval techniques. However, the centralized architecture of systems such as Google raises concerns in regard of the possibility to censure and to manipulate information. Promising alternatives are peer-to-peer search engines that organize themselves without any central index. We propose a distributed search engine that exploits XML structure of documents in order to improve effectiveness (search quality) and efficiency (resources) of the search. The developed system is based on a set of equal and autonomous peers. It is the first solution of its kind worldwide for distributed XML-Retrieval. Zusammenfassung Moderne Suchmaschinen sind sehr erfolgreich im Auffinden von relevanten Dokumenten. Die zentralisierte Architektur von Systemen wie Google bietet jedoch die Möglichkeit, Informationen zu zensieren und zu manipulieren. Selbstorganisierende Peer-to-Peer Suchsysteme dagegen kommen gänzlich ohne zentralen Index aus. Nachfolgend wird daher eine verteilte Suchmaschine präsentiert, bei der die XML-Struktur von Dokumenten ausgenutzt wird, um die Suche effektiver (Suchqualität) und effizienter (Ressourcenverbrauch) zu gestalten. Das entwickelte System basiert auf einem Zusammenschluss gleichberechtigter und autonomer Peers und ist die weltweit erste Lösung für verteiltes XML-Retrieval.