Miracle-dz/UniFAR-FTUs huggingface dataset:
Professional Learning in the Business Curriculum: Engaging Industry, Academics and Students

Professional Learning has become a feature of business curricula in universities around the world. The term “professional learning” (PL) is often used to encapsulate dimensions of educational programs that highlight contemporary industry issues explicitly linked to industry and professional bodies. PL encompasses the skills, qualities and attributes that are required by industry and the processes through which those skills are acquired. It encourages deep learning in relation to the student’s future profession, and includes industry engagement, work-integrated learning and authentic learning environments. This paper describes a typology of approaches to PL derived from a national study of good practices in business faculties in Australian universities. It identifies the enablers and impediments to the successful adoption of PL, and discusses the challenges associated with industry engagement in PL for academics, students and business organisations.
A Memetic-Grasp Algorithm for Clustering

A quick release winch tie down assembly is mounted in the tracks of a ramp of a car hauler vehicle and includes a crank shaft extending from one end through a segmented bearing sleeve, a release shaft connected to said crank shaft in nonrotatable telescopic arrangement, and a tie down sleeve extending about both the release shaft and crank shaft in a space between the bearing sleeve segments. A spring urges lock elements of the tie down sleeve and the release shaft in locking relationship. A tie down chain is connected at one end portion to the tie down sleeve, and a rachet and pawl means limits the rotation of crank shaft to one direction, so that when the crank shaft is rotated it also rotates the release shaft and tie down sleeve and winds the tie down chain about the tie down sleeve, and when the lock elements are disengaged, the tie down sleeve is free to rotate and unreel the tie down chain.
A Note on the Variation of the Rate of Disinfection with Change in the Concentration of the Disinfectant

In a recent paper by Miss Chick on “The Laws of Disinfection”, it was pointed out that disinfection of bacteria is strictly analogous to a chemical reaction in which individual bacteria play the part of molecules. Thus, if n be the number of bacteria present at any time t during dis-infection, , where K is a constant. Also, if K1, K2 are these constants for two different temperatures is also constant, i.e. Arrhenius' formula for the temperature coefficient of chemical reactions holds good in the case of bacteria as well. In addition to this, it was found that the relation between the concentration of the disinfectant and the time of disinfection (that is, the time required to reduce the original number of bacteria by a given percentage) might abe approximately expressed by the empirical law where C is the concentration at time t.
Development of a homogeneous assay for measurement of small dense LDL cholesterol.

BACKGROUND Plasma concentrations of small dense (sd)-LDL are associated with the prevalence of cardiovascular events. However, the special equipment and long assay times required for sd-LDL measurement have hindered its clinical application. Herein, we report development of a simple homogeneous assay for sd-LDL-cholesterol (C) adaptable to autoanalyzers. MATERIALS AND METHODS We identified suitable surfactants and phospholipases by screening for those selective for the sd-LDL fraction (d 1.044-1.063 kg/L) and for the dissociation of other lipoproteins, including large buoyant LDL (lb-LDL). Principal characteristics of this assay were compared with ultracentrifugal isolation of LDL subfractions and with our previous heparin-magnesium precipitation assay for sd-LDL. We measured sd-LDL-C concentrations in 460 healthy, normolipidemic individuals. RESULTS We used a polyoxyethylene benzylphenyl ether derivative to dissociate triglyceride-rich lipoproteins and HDLs, whereas sphingomyelinase proved most effective for dissociation of lb-LDL from LDL owing to the higher sphingomyelin content in the lb-LDL subfractions. A polyoxyethylene styrenephenyl ether derivative protected sd-LDL against the dissociative actions of sphingomyelinase and cholesterol oxidase/esterase during an initial incubation step. Next, polyoxyethylene alkyl ether dissociated sd-LDL-C and the cholesterol released from sd-LDL were subsequently measured by using cholesterol oxidase/esterase. The homogeneous method correlated excellently with ultracentrifugation for sd-LDL-C (y = 0.99x-0.09, R(2) = 0.91, n = 60) and exhibited within-run precision CVs <1.1%. The distribution of sd-LDL-C was skewed, and the central 95% of sd-LDL-C concentrations ranged from 0.24 to 0.88 mmol/L (9.4-34.0 mg/dL). CONCLUSIONS The homogeneous assay allows reproducible measurement of sd-LDL-C within 10 min and appears promising in further investigations of the clinical significance of sd-LDL-C.
Estimation of source location of leakage field from transformer-type microwave oven

A method to estimate the source location based on the MUSIC algorithm is proposed and is applied to the electromagnetic field emitted by a microwave oven of the transformer-type. Since the frequency, the phase and the amplitude of the leakage field emitted by a microwave oven change with time, a detection method using the periodicity of the field is also proposed to obtain the phase distribution. Experimental results are shown of the estimation of the source location using the proposed method.
Localisation of Nup153 and SENP1 to nuclear pore complexes is required for 53BP1-mediated DNA double-strand break repair

ABSTRACT The nuclear basket of nuclear pore complexes (NPCs) is composed of three nucleoporins: Nup153, Nup50 and Tpr. Nup153 has a role in DNA double-strand break (DSB) repair by promoting nuclear import of 53BP1 (also known as TP53BP1), a mediator of the DNA damage response. Here, we provide evidence that loss of Nup153 compromises 53BP1 sumoylation, a prerequisite for efficient accumulation of 53BP1 at DSBs. Depletion of Nup153 resulted in reduced SUMO1 modification of 53BP1 and the displacement of the SUMO protease SENP1 from NPCs. Artificial tethering of SENP1 to NPCs restored non-homologous end joining (NHEJ) in the absence of Nup153 and re-established 53BP1 sumoylation. Furthermore, Nup50 and Tpr, the two other nuclear basket nucleoporins, also contribute to proper DSB repair, in a manner distinct from Nup153. Similar to the role of Nup153, Tpr is implicated in NHEJ and homologous recombination (HR), whereas loss of Nup50 only affects NHEJ. Despite the requirement of all three nucleoporins for accurate NHEJ, only Nup153 is needed for proper nuclear import of 53BP1 and SENP1-dependent sumoylation of 53BP1. Our data support the role of Nup153 as an important regulator of 53BP1 activity and efficient NHEJ. Highlighted Article: Nup153, previously shown to be required for nuclear import of 53BP1, is also required for sumoylation of 53BP1, acting by displacing the SUMO protease SENP1, contributing to efficient DNA double-strand break repair.
Informe Mundial sobre el envejecimiento y la salud

Hoy en dia, por primera vez en la historia, la mayoria de las personas puede aspirar a vivir hasta entrados los 60 anos y mas. La mayor esperanza de vida, sumada a las caidas importantes en las tasas de fecundidad, es la causa del rapido envejecimiento de las poblaciones de todo el mundo.
Making ubicomp acceptable in the home

This thesis is concerned with the uses of ubiquitous computing (ubicomp) technologies in everyday domestic settings. In contrast to goal-oriented technology adoption (e.g. in the workplace), the integration of pervasive technology in the home faces not only social but also physical and technical constraints. We propose a design framework for the introduction of ubicomp technology into today’s homes that, firstly, considers a holistic approach to integrating pervasive technology; secondly, takes into account social factors and domestic activity when defining the nature of the system’s interaction; and thirdly, allows the user to adapt the system’s interaction and collaboration. Most of the work to date on domestic ubicomp takes the customization of domestic spaces for granted, presuming that the integration of sensing technologies can be accomplished to any required degree and usually assuming that context-aware systems have to be proactive, limiting users to the role of consumers of the system’s actions rather than allowing them a more participative or cooperative role. We have applied our framework to design a domestic ubicomp system to support parents with childcare in the home. The “Context-Aware Room” and the “The Parent-Child Companion Tool” prototypes are built to take account of the interaction between the social and physical and the social and digital contexts in order to address issues of integration of sensing technology, socially respectful collaboration and system adaptation. Two studies explore the potential social acceptance of the PChCT. The panel study considers parents’ overall perceptions of whether these kinds of ubicomp tools might help with parental tasks. The usability study considers the usefulness and usability of the PChCT. The results of the study reflect a positive attitude to the PChCT. Parents liked the collaborative resources and facilities to tailor collaboration. Further work might be done to assess how the system’s adaptation might fit within a wider context of user needs. Nevertheless, we argue that the use of our framework can lead to more socially acceptable ubicomp experiences in the home.
Evolutionary partitioning regression with function stacks

Partitioning regression is the simultaneous fitting of multiple models to a set of data and partitioning of that data into easily modelled classes. The key to partitioning regression with evolution is minimum error assignment during fitness evaluation. Assigning a point to the model for which it has the least error while using evolution to minimize total model error encourages the evolution of models that cleanly partition data. This study demonstrates the efficacy of partitioning regression using two or three models on simple bivariate data sets. Two novel multi-model representations, a simple evolutionary parameters setting algorithm and one based on using directed acyclic graphs representations for genetic programming are used. Possible generalizations to the general case of clustering are outlined.
Angiotensin II Type 2 Receptor Inhibits Vascular Endothelial Growth Factor–Induced Migration and In Vitro Tube Formation of Human Endothelial Cells

Abstract— Endothelial cell migration and tube formation in response to vascular endothelial growth factor (VEGF) play an important role in the process of angiogenesis. Recent data indicate that angiotensin type 2 (AT2) receptor stimulation is antiangiogenic. Therefore, we studied the effect of angiotensin II (Ang II) on VEGF-induced migration and in vitro tube formation of human endothelial cells. Ang II inhibited VEGF-induced migration of EA.hy926 cells, human coronary artery (HCA) and human dermal microvascular (HDM) endothelial cells (ECs) as well as tube formation by HDMECs. The AT2 receptor antagonist PD123,319 but not the AT1 receptor antagonist losartan blocked the inhibitory effect of Ang II. The inhibitory effect of Ang II on VEGF-induced migration of endothelial cells was mimicked by the specific AT2 receptor agonist CGP-42112A. The phosphorylation of Akt and its downstream effector endothelial NO synthase (eNOS) is pivotal to VEGF-induced angiogenesis. We therefore investigated the effect of Ang II on VEGF-induced Akt and eNOS phosphorylation. Ang II diminished the VEGF-induced phosphorylation of Akt and eNOS in endothelial cells, whereas the autophosphorylation of VEGF receptors was unaffected. CGP-42112A again mimicked and PD123,319 but not losartan blocked the inhibitory effect of Ang II. Treatment of endothelial cells with pertussis toxin (PTX) totally abolished the AT2 receptor–mediated inhibition of VEGF-induced endothelial cell migration and blocked the inhibition of Akt and eNOS phosphorylation. In conclusion, this study indicates that AT2 receptor stimulation inhibits VEGF-induced endothelial cell migration and tube formation via activation of a PTX-sensitive G protein. These findings may explain the reported antiangiogenic properties of the AT2 receptor.
Multiple Regulatory Domains Control IRF-7 Activity in Response to Virus Infection*

Recent studies implicate the interferon regulatory factors (IRF), IRF-3 and IRF-7, as key activators of Type 1 interferon genes, as well as the RANTES (regulated on activation normal T cell expressed) chemokine gene. Both IRF-3 and IRF-7 are regulated in part by virus-induced C-terminal phosphorylation, leading to nuclear translocation, stimulation of DNA binding, and transcriptional activities. Structure-function studies with IRF-7 suggested a complex organization of the C-terminal region, with a constitutive activation domain located between amino acids 150–246, an accessory inducibility region at the very end of IRF-7 between amino acids 467 and 503, and an inhibitory region (amino acids 341–467) adjacent to the C-terminal end that interferes with transactivation. Furthermore, an element that increases basal and virus-inducible activity is located between amino acids 278 and 305. A transcriptionally active form of IRF-7 was also generated by substitution of Ser-477 and Ser-479 residues with the phosphomimetic Asp. IRF-7, particularly IRF-7(S477D/S479D), was a strong transactivator of type I interferon and RANTES chemokine gene expression. Unlike wild type IRF-3, IRF-7 overexpression was able to stimulate inteferon gene expression in the absence of virus infection. Using tagged versions of IRF-7 and IRF-3, the formation of homo- and heterodimers was detected by co-immunoprecipitation. These results demonstrate that IRF-3 and IRF-7 transcription factors possess distinct structural characteristics that impart complementary rather than redundant functional roles in cytokine gene activation.
The eyeless mouse mutation (ey1) removes an alternative start codon from the Rx/rax homeobox gene

Summary: The eyeless inbred mouse strain ZRDCT has long served as a spontaneous model for human anophthalmia and the evolutionary reduction of eyes that has occurred in some naturally blind mammals. ZRDCT mice have orbits but lack eyes and optic tracts and have hypothalamic abnormalities. Segregation data suggest that a small number of interacting genes are responsible, including at least one major recessive locus, ey1. Although predicted since the 1940s, these loci were never identified. We mapped ey1 to chromosome 18 using an F2 genome scan and there found a Met10→Leu mutation in Rx/rax, a homeobox gene that is expressed in the anterior headfold, developing retina, pineal, and hypothalamus and is translated via a leaky scanning mechanism. The mutation affects a conserved AUG codon that functions as an alternative translation initiation site and consequently reduces the abundance of Rx protein. In contrast to a targeted Rx null allele, which causes anophthalmia, central nervous system defects, and neonatal death, the hypomorphic M10L allele is fully viable. genesis 31:43–53, 2001. © 2001 Wiley‐Liss, Inc.
A Gripping Tale of Ribosomal Frameshifting: Extragenic Suppressors of Frameshift Mutations Spotlight P-Site Realignment

SUMMARY Mutants of translation components which compensate for both −1 and +1 frameshift mutations showed the first evidence for framing malleability. Those compensatory mutants isolated in bacteria and yeast with altered tRNA or protein factors are reviewed here and are considered to primarily cause altered P-site realignment and not altered translocation. Though the first sequenced tRNA mutant which suppressed a +1 frameshift mutation had an extra base in its anticodon loop and led to a textbook “yardstick” model in which the number of anticodon bases determines codon size, this model has long been discounted, although not by all. Accordingly, the reviewed data suggest that reading frame maintenance and translocation are two distinct features of the ribosome. None of the −1 tRNA suppressors have anticodon loops with fewer than the standard seven nucleotides. Many of the tRNA mutants potentially affect tRNA bending and/or stability and can be used for functional assays, and one has the conserved C74 of the 3′ CCA substituted. The effect of tRNA modification deficiencies on framing has been particularly informative. The properties of some mutants suggest the use of alternative tRNA anticodon loop stack conformations by individual tRNAs in one translation cycle. The mutant proteins range from defective release factors with delayed decoding of A-site stop codons facilitating P-site frameshifting to altered EF-Tu/EF1α to mutant ribosomal large- and small-subunit proteins L9 and S9. Their study is revealing how mRNA slippage is restrained except where it is programmed to occur and be utilized.
H∞ control for discrete-time singular delay systems

In this paper, H<inf>∞</inf> control for discrete-time singular delay systems is addressed. Firstly, H<inf>∞</inf> performance analysis for discrete-time singular delay systems is studied. Then, by applying the skill of matrix theory, H<inf>∞</inf> controller design is given to guarantee the closed-loop discrete-time singular delay systems to be regular, casual and stable and satisfy the H<inf>∞</inf> performance. Finally, numerical example is given to demonstrate the effectiveness of the proposed method.
Controlled phase shifters model for power grid operating modes calculation

This paper presents controlled phase shifters (CPS) unified model (UM) for power grid modes calculation. Internal different topologies of CPS which affect the parameters of the UM are considered. Parameters of UM for various CPS topologies are calculated and analyzed. The influences of different topologies and control on transfer functions of CPS are investigated. The implementation of UM for calculation of operating modes of a three-phase power grid with CPS based on thyristor controlled phase angle regulator (TCPAR) is presented. CPS impacts on operation modes of power grid are analyzed.
An empirical model for estimating world-wide deposition from atmospheric nuclear detonations.

An empirical model is presented for estimating the surface deposition of “worldwide’’ radioactivity from atmospheric nuclear detonations given the yield, latitude, season and type of each burst. The procedure is readily adaptable to computer calculation. The model is based primarily on injection-deposition experience gained from the U.S. and U.S.S.R. nuclear tests in 1958. Use of the technique to estimate %r deposition from the 1961-62 tests shows the predictions are usually within a factor of two of the observed deposition.
Rejoinder: Remaining Challenges in Investigating Grade-Retention Effectiveness

ABSTRACT This rejoinder, in response to the commentaries of Steiner, Park, and Kim (this issue) and Reshetnyak, Cham, and Hughes (this issue), discusses remaining challenges in grade retention research. First, a same-age comparison assumes that the instruments used in different grades measure ability equally well. We discuss the importance of evaluating the properties of the scaling process to address whether this assumption has been met. Second, we discuss issues in the selection of covariates to be included in the weights. Third, we discuss the unconfoundedness assumption and the problem of remaining imbalance. Finally, we provide an empirical illustration showing that studying grade-retention effectiveness comes with multiple methodological decisions that are rooted in a bias–variance trade-off.
A novel method for modeling semiconductor by neuro space mapping

The drift-diffusion (DD) model is not accurate for simulation of submicrometer semiconductor devices. Using RBF NN, a neuro space mapping is proposed to DD model parameters. The DD model with mapped parameters can produce accurate simulation results of the hydrodynamic model. Simulations of a n-i-n diode confirm the ability of the proposed method for submicron device simulation.
Adaptive dynamics, game theory and evolutionary population genetics

The most important question that one can ask about a method for scientifically investigating a natural phenomenon is whether that method is of any use. Does it tell us something we did not previously know? Does it lead us to ask novel questions, or better understand the observations under study? It seems to us that, although some of the examples provided by Waxman & Gavrilets (2004) suggest that adaptive dynamics has been a productive tool, many of the studies they cite could have been carried out using existing alternative approaches, which, in some cases, might have led to different – or at least more complete – answers. Thus, we argue that adaptive dynamics fails the utility test on two grounds. Firstly, well-established methods can deal with the problems that the adaptive dynamics approach purports to solve, sometimes by using exactly the same mathematical techniques. And secondly, by avoiding the mathematical simplifications entailed by adaptive dynamics, some of these alternative analyses lead to a better understanding of the underlying biology.
Trends in dengue diagnosis

The conventional diagnosis of dengue virus infections includes the detection of the virus in serum or tissue samples, both by isolation in culture or through detection of specific viral molecules (genome RNA or dengue antigens) and detection of specific anti‐dengue antibodies (serology). Isolation of dengue virus provides the most direct and conclusive approach to diagnosis, despite the demand for high‐level equipment, technical skills and manpower. However, it is useless in early diagnosis because several days are required to isolate and classify the virus. Serology, despite being simpler, is not able to afford an accurate early diagnosis in primary infections because 4–5 days are required for the immune system to produce a sufficient amount of antibodies. Moreover, it leads to misleading results in secondary infections owing to cross‐reactivity among serotype‐specific antibodies and with other flavivirus antibodies. The RT‐PCR and other PCR‐based techniques are fast, serotype‐discriminating, more sensitive and easier to carry out than conventional nucleic‐acid hybridisation, but are handicapped by easy sample contamination and high technological demands. Recently, advances in bioelectronics have generated commercial kits and new techniques for detection of dengue antibodies and RNA, based on biosensor technology. Most of them are rapid, easy to operate, reusable, cheap, sensitive and serotype‐specific. Nevertheless, their accuracy is still questionable because most still lack validation and standardisation. This review summarises and describes the techniques currently employed and anticipated in the near future for diagnosis of dengue disease. Copyright © 2005 John Wiley & Sons, Ltd.