Miracle-dz/UniFAR-FTUs huggingface dataset:
Time-Triggered Scheduling of Mixed-Criticality Systems

Real-time and embedded systems are moving from the traditional design paradigm to integration of multiple functionalities onto a single computing platform. Some of the functionalities are safety critical and subject to certification. The rest of the functionalities are nonsafety critical and do not need to be certified. Designing efficient scheduling algorithms which can be used to meet the certification requirement is challenging. Our research considers the time-triggered approach to scheduling of mixed-criticality jobs with two criticality levels. The first proposed algorithm for the time-triggered approach is based on the OCBP scheduling algorithm which finds a fixed-priority order of jobs. Based on this priority order, the existing algorithm constructs two scheduling tables SLOoc and SHIoc. The scheduler uses these tables to find a scheduling strategy. Another time-triggered algorithm called MCEDF was proposed as an improvement over the OCBP-based algorithm. Here we propose an algorithm which directly constructs two scheduling tables without using a priority order. Furthermore, we show that our algorithm schedules a strict superset of instances which can be scheduled by the OCBP-based algorithm as well as by MCEDF. We show that our algorithm outperforms both the OCBP-based algorithm and MCEDF in terms of the number of instances scheduled in a randomly generated set of instances. We generalize our algorithm for jobs with m criticality levels. Subsequently, we extend our algorithm to find scheduling tables for periodic and dependent jobs. Finally, we show that our algorithm is also applicable to mixed-criticality synchronous programs upon uniprocessor platforms and schedules a bigger set of instances than the existing algorithm.
‘Behemoth Pulls the Peasant’s Plough’: Convergence and Resistance to Business Civilization in China

Abstract It has been widely held that China’s development was forged from a unique pathway to that of Western countries. As a result, it has been assumed that China’s historical experience of modernization contains important lessons for other developing states. However, as we show, modernization in China can be seen as sharing many of the same assumptions of development as the West. Using insights from Cox’s work on civilizations—particularly the notion of ‘Business Civilization’ (adapted from Susan Strange)—our paper examines how modernization theoretic assumptions underpin both Chinese and World Bank perspectives on agricultural development not only within China but also across their engagements, policies, and practices of development throughout Africa. We argue that development constitutes a political project historically inseparable from La mission civilisatrice of Business Civilization, extending a form of intersubjectivity and materiality, power and rationality, based on a specific civilizational worldview. This process retains a number of contradictions and points of conflict and we focus on the resistances of traditional forms of civilization in contestations around the imposition of commercialized agriculture.
Sequence to Sequence Learning for Event Prediction

This paper presents an approach to the task of predicting an event description from a preceding sentence in a text. Our approach explores sequence-to-sequence learning using a bidirectional multi-layer recurrent neural network. Our approach substantially outperforms previous work in terms of the BLEU score on two datasets derived from WikiHow and DeScript respectively. Since the BLEU score is not easy to interpret as a measure of event prediction, we complement our study with a second evaluation that exploits the rich linguistic annotation of gold paraphrase sets of events.
An application layer multi-source multicast with proactive route maintenance

Application layer multicast is an alternative to network layer multicast. The existing application layer multicast approaches are focus on single source multicast and insufficient in supporting distributed applications that require multi-source and fast recovery abilities with dynamic membership. This paper proposes a novel application layer multicast and its proactive recovery approaches for multi-source applications. The member in the proposed approach configures a partial tree structure for each source-specific data delivery tree, and then the cooperative execution of the proposed approach at each member defines an implicit multicast delivery tree for each source node. The implicit delivery tree structure can not only avoid bottleneck and single point-of-failure problems of single share-tree solution suggested in [2], but also simplify the recovery from node departures to table-lookup operations. Extensive simulations demonstrate that our proposal is effective to handle multi-source multicast delivery and reduce recovery time caused by departed nodes.
Comparative Teaching Method: Its Application into Teaching of Courses of Laws

Legal education shoulders the responsibility of "rejuvenating China through science and education" as well as "administrating the nation by laws". The new time issues a new higher requirement for legal education. The laws comparative teaching method stresses the differences and similarities among various laws and reveals the intrinsic quality of laws in an all-round way. Therefore, it plays a very important role in achieving the purpose and object of laws teaching and should be applied in the teaching practice.
Homeostasis in Human B Cells Soluble CD23 Controls IgE Synthesis and

CD23, the low-afﬁnity receptor for IgE, exists in membrane and soluble forms. Soluble CD23 (sCD23) fragments are released from membrane (m)CD23 by the endogenous metalloprotease a disintegrin and metalloprotease 10. When puriﬁed tonsil B cells are incubated with IL-4 and anti-CD40 to induce class switching to IgE in vitro, mCD23 is upregulated, and sCD23 accumulates in the medium prior to IgE synthesis. We have uncoupled the effects of mCD23 cleavage and accumulation of sCD23 on IgE synthesis in this system. We show that small interfering RNA inhibition of CD23 synthesis or inhibition of mCD23 cleavage by an a disintegrin and metalloprotease 10 inhibitor, GI254023X, suppresses IL-4 and anti-CD40–stimulated IgE synthesis. Addition of a recombinant trimeric sCD23 enhances IgE synthesis in this system. This occurs even when endogenous mCD23 is protected from cleavage by GI254023X, indicating that IgE synthesis is positively controlled by sCD23. We show that recombinant trimeric sCD23 binds to cells coexpressing mIgE and mCD21 and caps these proteins on the B cell membrane. Upregulation of IgE by sCD23 occurs after class-switch recombination, and its effects are isotype-speciﬁc. These results suggest that mIgE and mCD21 cooperate in the sCD23-mediated positive regulation of IgE synthesis on cells committed to IgE synthesis. Feedback regulation may occur when the concentration of secreted IgE becomes great enough to allow binding to mCD23, thus preventing further release of
A Lightweight Authentication Mechanism for M2M Communications in Industrial IoT Environment

In the emerging industrial Internet of Things (IIoT) era, machine-to-machine (M2M) communication technology is considered as a key underlying technology for building IIoT environments, where devices (e.g., sensors, actuators, and gateways) are enabled to exchange information with each other in an autonomous way without human intervention. However, most of the existing M2M protocols that can be also used in the IIoT domain provide security mechanisms based on asymmetric cryptography resulting in high computational cost. As a consequence, the resource-constrained IoT devices are not able to support them appropriately and thus, many security issues arise for the IIoT environment. Therefore, lightweight security mechanisms are required for M2M communications in IIoT in order to reach its full potential. As a step toward this direction, in this paper, we propose a lightweight authentication mechanism, based only on hash and XOR operations, for M2M communications in IIoT environment. The proposed mechanism is characterized by low computational cost, communication, and storage overhead, while achieving mutual authentication, session key agreement, device’s identity confidentiality, and resistance against the following attacks: replay attack, man-in-the-middle attack, impersonation attack, and modification attack.
Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.

Trypanosoma and Leishmania, pathogens responsible for diseases such as African sleeping sickness, Chagas' heart disease, or Oriental sore, are two of the very few genera that do not use the ubiquitous glutathione/glutathione reductase system to keep a stable cellular redox balance. Instead, they rely on trypanothione and trypanothione reductase to protect them from oxidative stress. Trypanothione reductase (TR) and the corresponding host enzyme, human red blood cell glutathione reductase (GR), belong to the same flavoprotein family. Despite their closely related three-dimensional structures and although their natural substrates share the common structural glutathione core, the two enzymes are mutually exclusive with respect to their disulfide substrates. This makes the parasite enzyme a potential target for antitrypanosomal drug design. While a large body of structural data on GR complexes is available, information on TR-ligand interactions is very limited. When the two amino acid changes Ala34Glu and Arg37Trp are introduced into human GR, the resulting mutant enzyme (GRTR) prefers trypanothione 700-fold over its original substrate, effectively converting a GR into a TR [Bradley, M. , Bücheler, U. S. , & Walsh, C. T. (1991) Biochemistry 30, 6124-6127]. The crystal structure of GRTR has been determined at 2.3 A resolution and refined to a crystallographic R factor of 20.9%. We have taken advantage of the ease with which ligand complexes can be produced in GR crystals, a property that extends to the isomorphous GRTR crystals, and have produced and analyzed crystals of GRTR complexes with glutathione, trypanothione, glutathionylspermidine and of a true catalytic intermediate, the mixed disulfide between trypanothione and the enzyme. The corresponding molecular structures have been characterized at resolutions between 2.3 and 2.8 A with R factors ranging from 17.1 to 19.7%. The results indicate that the Ala34Glu mutation causes steric hindrance leading to a large displacement of the side chain of Arg347. This movement combined with the change in charge introduced by the mutations modifies the binding cavity, forcing glutathione to adopt a nonproductive binding mode and permitting trypanothione and to a certain degree also the weak substrate glutathionylspermidine to assume a productive mode.
Maternal childhood abuse and offspring adjustment over time

This study addressed the basis for the intergenerational transmission of psychosocial risk associated with maternal childhood abuse in relation to offspring adjustment. The study tested how far group differences in individual change in adjustment over time were explained by differences in exposure to specific environmental risk experiences. Data are drawn from the Avon Longitudinal Study of Parents and Children. Information on mothers' own experience of childhood abuse, offspring adjustment at ages 4 and 7 years, and hypothesized mediators was available for 5,619 families. A residuals scores analysis was used to track children's adjustment over time. Maternal childhood abuse was associated with poorer behavioral trajectories between ages 4 and 7 years. Children of abused mothers were more likely to experience a range of negative life events between ages 4 and 7 years, including changes in family composition, separations from parents, “shocks and frights” and physical assaults. Interim life events, together with antecedent psychosocial risk (maternal antenatal affective symptoms, age 4 parental hostility, age 4 family type) fully mediated the association between maternal childhood abuse and offspring prognosis.The authors express their gratitude to the families who participated in the study. Support for these analyses was provided by a grant from the Medical Research Council. The Avon Longitudinal Study of Parents and Children (ALSPAC) is part of the World Health Organisation initiated European Study of Pregnancy and Childhood, and is supported, among others, by the Wellcome Trust, The Department of Health, The Department of the Environment, and the Medical Research Council. The ALSPAC study team comprises interviewers, computer technicians, laboratory technicians, clerical workers, research scientists, volunteers, and managers who continue to make the study possible.
Antenna group selection based user scheduling for massive MIMO systems

Accurate transmit-side channel state information (CSI) is essential for achieving optimal performance of large-scale multiple-input multiple-output (MIMO) systems. However, due to high dimensionality of the massive MIMO systems, large overhead of the uplink CSI feedback is a big concern for frequency division duplexing (FDD) systems. In this paper, we propose antenna group scheduling (AGS) algorithm that combines antenna selection and user scheduling for pursuing further reduction in feedback overhead. The AGS method selects the antenna group with the maximum channel gain to reduce the dimension of channel vector and schedules users in the group maximizing the sum rate. Simulation results demonstrate that the proposed technique achieves significant feedback overhead reduction over the conventional beamforming techniques (33%~50%) under the same target sum rate requirement.
Measures of suicidality in phase 3 clinical trials of levomilnacipran ER in adults with major depressive disorder

Objective To evaluate the effects of levomilnacipran extended-release (ER) on suicidal ideation and behavior in adults with major depressive disorder (MDD). Methods Post hoc analyses were conducted in patients from 4 randomized, double-blind, placebo-controlled trials and a long-term, open-label extension study of levomilnacipran ER (40-120 mg/d) in adults with MDD. Analyses included incidence of suicide-related treatment-emergent adverse events (TEAEs); incidence of Columbia–Suicide Severity Rating Scale (C-SSRS) suicidal ideation (score=1–5) and behavior (score=6-10); percent of patients who shifted from no C-SSRS suicidal ideation/behavior at baseline to suicidal ideation during treatment (worsened from score=0 to score=1–5), or vice-versa (improved from score=1-5 to score=0). Results Suicide-related TEAEs occurred in<1% of patients in the levomilnacipran ER studies. The incidence of C-SSRS suicidal ideation was 22.2%, 23.9%, and 21.7% for placebo, short-term levomilnacipran ER, and long-term levomilnacipran ER, respectively; C-SSRS suicidal behavior was<1% in all of these groups. In the short-term studies, the percentage of patients with C-SSRS shifts were as follows: worsening from score=0 to score=1–5 (placebo, 8.6%; levomilnacipran ER, 11.0%); improvement from score=1–5 to score=0 (placebo, 24.0%; levomilnacipran ER, 27.7%). Conclusion In adult MDD patients, the incidence of suicidal ideation and behavior was similar between placebo and short-term levomilnacipran ER as indicated by TEAE reports and C-SSRS scores. Worsening in C-SSRS scores was also similar between placebo and levomilnacipran ER. There was no indication of increased suicidality during longer courses of continued therapy. Together, these findings suggest that this medication is not associated with increased risks of suicidal ideation or behavior.
Characterization of two genes required for the position‐effect control of yeast mating‐type genes.

The mating type of haploid yeast (a or alpha) is determined by information present at the MAT locus. Identical copies of a and alpha information are present at distal loci (HMR and HML), but transcription of these copies is repressed by the action, in trans, of four unlinked genes called SIR (silent information regulator). Repression by SIR also requires, in cis, DNA sequences called E which are found to the left of HML and HMR (but not MAT) and are greater than 1 kb from the mating‐type gene promoters. SIR control can act on other promoters when they are brought near the E sequence, and thus the SIR gene products act in some general manner to repress transcription. We have determined the DNA sequence of two fragments which complement mutations in the SIR2 and SIR3 genes and show that these contain the structural genes by mapping the cloned sequences onto the yeast chromosome. The SIR2 and SIR3 coding sequences were identified by constructing gene disruptions and using these mutations to replace the normal chromosomal copies. Such null mutants of both SIR2 and SIR3 are defective in the position‐effect control of the silent loci but have no other detectable phenotype. We have mapped the 5′ and 3′ ends of the SIR2 and SIR3 mRNAs and show that their level is unaffected by mutations in any of the four known SIR complementation groups.
Receptor-Ligand Interactions Studied with Homogeneous Fluorescence-Based Assays Suitable for Miniaturized Screening

Cell membrane receptors play a central role in controlling cellular functions, making them the target of drugs for a wide variety of diseases. This report describes how a recently developed method, fluorescence intensity distribution analysis (FIDA), can be used to develop homogeneous, nonradioactive high throughput screening assays for membrane receptors. With FIDA, free ligand and ligand accumulated on receptor-bearing membrane vesicles can be distinguished on the basis of their particle brightness. This allows the concentration of both bound and free ligand to be determined reliably from a single measurement, without any separation. We demonstrate that ligand affinity, receptor expression level, and potency of inhibitors can be determined using the epidermal growth factor and β2-adrenergic receptors as model systems. Highly focused confocal optics enable single-molecule sensitivity, and sample volumes can thus be reduced to 1,IL without affecting the quality of the fluorescence signal. Our results demonstrate that FIDA is an ideal method for membrane receptor assays offering substantial benefits for assay development and high throughput pharmaceutical screening.
Portable dynamometer anchoring station for measuring strength of the hip extensors and abductors.

OBJECTIVE To assess the reliability of a specially designed dynamometer anchoring station in the measurement of hip muscle strength. DESIGN Prospective study using test-retest design. SETTING Outpatient clinic setting. PARTICIPANTS Ten subjects, ages 25 to 35yrs. MAIN OUTCOME MEASURES Using the apparatus, three consecutive measures were recorded for hip abduction and extension by an inexperienced examiner. Two weeks later, the same subjects were retested, with the evaluator blinded to the initial results. In both the test and retest, average and maximal values of strength were calculated for each muscle. Reliability of the device was assessed by computing the intraclass correlation coefficients and coefficients of variation (CVs). RESULTS Intraclass correlation coefficients ranged from . 94 to . 98. The average CV for the maximal and average abduction strength had values of 4.77% and 4%, respectively. The maximal and average extension strength had average CV values of 8.06% and 7.83%, respectively. CONCLUSION This specially designed dynamometer anchoring station has been found to be highly reliable in the measurement of hip girdle strength and has the advantage of easy adjustability and portability for large-scale screenings. This device enhances the reliability of the dynamometer, which may be subject to considerable variability when applied by hand to the powerful hip girdle musculature.
Periodontal conditions in adolescents with cleft lip, alveolus and palate following treatment in a co-ordinated team approach.

The aim of the present investigation was to evaluate the oral hygiene habits and the periodontal conditions of a group of cleft lip, alveolus and palate patients at the end of a longitudinal multidisciplinary treatment. From a total of 120 patients who had been supervised at the University of Berne, Clinic for Pediatric Surgery for at least 18 years in a co-ordinated team approach, 80 were selected on the basis of availability. Plaque control record (PCR), calculus index (CI), gingival bleeding index (GBI), pocket probing depth (PD), loss of attachment (LA) and furcation involvement were recorded. Using the technique and the ruler described by Schei et al., the radiographic height of the alveolar crest from the cemento-enamel junction was determined. Between the different groups of deformities, no statistically significant differences were found for all the clinical parameters with the exception of the mean PD orally and the mean PD bucally which were shallower in the isolated cleft lip group. These differences were attributed to the long-term orthodontic therapy with fixed appliances. When the PD and the LA at the sites adjacent to the cleft region were compared to two "unaffected" control sites, no statistically significant differences were found, whereas the comparison with the radiographic bone loss showed a statistically significant lower bone height. These results may indicate the presence of a long connective tissue attachment without bony support in the cleft region. As a result of inadequate oral hygiene, the patients with cleft lip, alveolus and palate showed beginning periodontitis with loss of attachment and beginning furcation involvement in most of the cases. (ABSTRACT TRUNCATED AT 250 WORDS)
The contribution of intraabdominal fat to gender differences in hepatic lipase activity and low/high density lipoprotein heterogeneity.

Hepatic lipase (HL) hydrolyzes triglyceride and phospholipid in low and high density lipoprotein cholesterol (LDL-C and HDL-C, respectively), and elevated HL activity is associated with small, dense atherogenic LDL particles and reduced HDL2-C. Elevated HL activity is associated with increasing age, male gender, high amounts of intraabdominal fat (IAF), and the HL gene (LIPC) promoter polymorphism (C nucleotide at -514). We investigated the mechanisms underlying the difference in HL activity between men (n = 44) and premenopausal women (n = 63). Men had significantly more IAF (144.5 +/- 80.9 vs. 66.5 +/- 43.2 cm(2), respectively; P < 0.001), higher HL activity (220.9 +/- 94.7 vs.129.9 +/- 53.5 nmol/mL.min; P < 0.001), more dense LDL (Rf, 0.277 +/- 0.032 vs. 0.300 +/- 0.024; P = 0.01), and less HDL2-C (0.19 +/- 0.10 vs. 0.32 +/- 0.16 mmol/L; P < 0.001) than women. After adjusting for IAF and the LIPC polymorphism, men continued to have higher (but attenuated) HL activity (194.5 +/- 80.4 vs.151.0 +/- 45.2, respectively; P = 0.007) and lower HDL2-C (0.23 +/- 0.11 vs. 0.29 +/- 0.14 mmol/L; P = 0.02) than women. Using multiple regression, HL activity remained independently related to IAF (P < 0.001), gender (P < 0.001), and the LIPC genotype (P < 0.001), with these factors accounting for 50% of the variance in HL activity. These data suggest that IAF is a major component of the gender difference in HL activity, but other gender-related differences, perhaps sex steroid hormones, also contribute to the higher HL activity seen in men compared with premenopausal women. The higher HL activity in men affects both LDL and HDL heterogeneity and may contribute to the gender difference in cardiovascular risk.