Miracle-dz/UniFAR-FTUs huggingface dataset:
Economic framework for resource management in data centers

Data centers consume more energy than ever. However, recent works prove that one third of the total energy consumed is wasted by keeping servers in comatose and almost half by keeping them in comatose and idle. To address this issue, we have developed an economic framework and a model based on the servers On-Off technique and semi-Markov Decision Process. This approach provides an optimal policy that minimizes data center's power consumption and maximizes the Cloud Provider's profit. The model allows updating dynamically the number of active servers in a data center according to the traffic. In the tested scenarios the proposed approach saves up to 66% of total energy consumed.
The Functional and the Instrumental in Market Definition: a Laboratory for Natural Experiments in the Baltics.........................................................

Reforms of natural monopolies need clear delineations between the industries where market mechanisms contribute to social welfare and those where the costs of a transition to a market economy outweigh the benefits. In this article, we emphasise the difficulty of finding the optimum modes of governance within industries as a whole. Using the tools of the transaction cost economics, we show that, alongside the problem of market boundaries and the resultant position and behaviour of a company — an object of antimonopoly regulation — it is necessary to consider the hypothesis about the market being a special mechanism for coordinating interactions between economic entities. In particular, such determinants of transactions as asset specificity, uncertainty, and frequency can create a basis for abandoning the price mechanism. Williamson’s heuristic models suggest that if an activity is characterized by high specificity, uncertainty, and frequency, the very organisation of this activity precludes transaction cost minimisation through the price mechanism employed either in full or in part (hybrid institutional agreements). This can be explained by excessive risks and ensuing high transaction costs. A more efficient solution is the organisation of interactions within a group of legal entities in control (within a single economic entity). In order to compare the practical implementation of institutional alternatives, we examine the modes of governance in the gas supply industry. A major focus is the Baltic region where two interconnected pipelines — the Nord Stream and the OPAL — were constructed. Different ways to handle transactions relating to gas supply were employed at the time. We compare these ways THE FUNCTIONAL
Urinary Bactericidal Activity of Doripenem versus That of Levofloxacin in Patients with Complicated Urinary Tract Infections or Pyelonephritis

ABSTRACT The aim of this study was to investigate the urinary bactericidal titers (UBTs) and 24-h area under the UBT-versus-time curve (AUBT) of intravenous doripenem (500 mg every 8 h [q8h]), a new carbapenem, versus those of intravenous levofloxacin (250 mg q24h) in patients with complicated urinary tract infections (cUTIs) or pyelonephritis. UBTs and AUBTs are pharmacokinetic/pharmacodynamic parameters able to reflect the activity of an antimicrobial substance in the urine. Doripenem and levofloxacin show comparable urinary excretion of approximately 80% and are therefore registered for the treatment of UTIs. In order to assess and compare the urinary antimicrobial activities of the two substances, UBTs were investigated for 24 patients (10 treated with doripenem and 14 with levofloxacin) for 31 uropathogens and one control strain. Eight strains were tested for all patients and 27 only in the urine of the corresponding patient. Median UBTs (AUBTs) of doripenem for the uropathogens tested ranged between 1.5 and 65,536 (224 and 909,312) and were significantly higher than median UBTs (AUBTs) of levofloxacin, ranging between 0 and 128 (0 and 2,208). Eight microbiological failures were observed, three after doripenem treatment and five after levofloxacin treatment. For levofloxacin, microbiological failures correlated well with low UBTs and AUBTs, whereas for doripenem there was no correlation. From this study, a calculated target attainment rate for levofloxacin predicting therapeutic success in patients with UTIs approximated mean UBTs of 100 over 24 h or AUBTs of 2,240. Doripenem demonstrated excellent urinary bactericidal activity with the dose administered and appears to be a good alternative in the empirical treatment of cUTI.
A review of mild head trauma. Part I: Meta-analytic review of neuropsychological studies.

We conducted a meta-analytic review of neuropsychological studies of mild head trauma (MHT). Studies were included if they met these criteria: patients studied at least 3 months after MHT; patients selected because of a history of MHT rather than because they were symptomatic; and attrition rate of less than 50% for longitudinal studies. Studies of children were not considered. We found a total of 8 published papers with 11 samples that met these criteria. Using the g statistics, the overall effect size of 0.07 was nonsignificant, but the d statistic yielded an effect size of 0.12, p < . 03. Measurers of attention had the largest effect, g = 0.17. p < . 02 and d = 0.20, p < . 006. Severity of injury accounted for far more variance than did specific neuropsychological domain, however. The small effect size suggests that the maximum prevalence of persistent neuropsychological deficit is likely to be small and neuropsychological assessment is likely to have positive predictive value of less than 50%. Consequently, clinicians will more likely be correct when not diagnosing brain injury than when diagnosing a brain injury in cases with chronic disability after MHT.
Tetrabromido[4-(triphenylphosphanyloxy)butyl]tellurium acetonitrile monosolvate

In the title compound, [TeBr4(C22H23OP)]·CH3CN, the Te atom exhibits a square-pyramidal coordination with an apical Te—C bond and four basal Te—Br bonds. The conformation of the aliphatic C—C—C—C chain is gauche [torsion angle = −67.7 (8)°]. A weak C—H⋯Br interaction helps to establish the conformation. In the crystal, there is a weak secondary bonding interaction [Te⋯N = 3.456 (11) Å] between the Te atom and the N atom of the solvent molecule, which completes a distorted TeNCBr4 octahedron. Inversion dimers linked by pairs of C—H⋯Br interactions are also observed.
Spiral Propagation of Polymer Optical Fiber Fuse Accompanied by Spontaneous Burst and Its Real-Time Monitoring Using Brillouin Scattering

We study the propagation behavior of the polymer optical fiber (POF) fuse at a power density up to several tens of kW/cm2 (corresponding to subwatt power). The propagation velocity is raised in proportion to the power density, reaching 41 mm/s at 67 kW/cm2. We also observe spiral oscillation and spontaneous termination of the fuse propagation, with the latter accompanied by a burst. We then develop a new method of detecting the location of the propagating POF fuse remotely and non visually in real time using Brillouin scattering, which can be clearly observed at such a high power density. This method requires neither additional light injection nor signal integration, and it could be used to monitor the propagating fuse in glass fibers.
Treatment of PTLD with Rituximab or Chemotherapy

Information regarding treatment of post‐transplant lymphoproliferative disease (PTLD) beyond reduction in immunosuppression (RI) is limited. We retrospectively evaluated patients receiving rituximab and/or chemotherapy for PTLD for response, time to treatment failure (TTF) and overall survival (OS). Thirty‐five patients met inclusion criteria. Twenty‐two underwent rituximab treatment, with overall response rate (ORR) 68%. Median TTF was not reached at 19 months and estimated OS was 31 months. In univariable analysis, Epstein‐Barr virus (EBV) positivity predicted response and TTF. LDH elevation predicted shorter OS. No patient died of rituximab toxicity and all patients who progressed underwent further treatment with chemotherapy. Twenty‐three patients received chemotherapy. ORR was 74%, median TTF was 10.5 months and estimated OS was 42 months. Prognostic factors for response included stage, LDH and allograft involvement by tumor. These factors and lack of complete response (CR) predicted poor survival. Twenty‐six percent of the patients receiving chemotherapy died of toxicity. Rituximab and chemotherapy are effective in patients with PTLD who fail or do not tolerate RI. While rituximab is well tolerated, toxicity of chemotherapy is marked. PTLD patients requiring therapy beyond RI should be considered for rituximab, especially with EBV‐positive disease. Chemotherapy should be reserved for patients who fail rituximab, have EBV‐negative tumors or need a rapid response.
O-Acetylserine and the Regulation of Expression of Genes Encoding Components for Sulfate Uptake and Assimilation in Potato1

cDNAs encoding a high-affinity sulfate transporter and an adenosine 5′-phosphosulfate reductase from potato (Solanum tuberosum L. cv Désirée) have been cloned and used to examine the hypothesis that sulfate uptake and assimilation is transcriptionally regulated and that this is mediated via intracellular O-acetylserine (OAS) pools. Gas chromotography coupled to mass spectrometry was used to quantify OAS and its derivative, N-acetylserine. Treatment with external OAS increased sulfate transporter and adenosine 5′-phosphosulfate reductase gene expression consistent with a model of transcriptional induction by OAS. To investigate this further, the Escherichia coli gene cysE (serine acetyltransferase EC 2.3.1.30), which synthesizes OAS, has been expressed in potato to modify internal metabolite pools. Transgenic lines, with increased cysteine and glutathione pools, particularly in the leaves, had increased sulfate transporter expression in the roots. However, the small increases in the OAS pools were not supportive of the hypothesis that this molecule is the signal of sulfur (S) nutritional status. In addition, although during S starvation the content of S-containing compounds decreased (consistent with derepression as a mechanism of regulation), OAS pools increased only following extended starvation, probably as a consequence of the S starvation. Taken together, expression of these genes may be induced by a demand-driven model, via a signal from the shoots, which is not OAS. Rather, the signal may be the depletion of intermediates of the sulfate assimilation pathway, such as sulfide, in the roots. Finally, sulfate transporter activity did not increase in parallel with transcript and protein abundance, indicating additional posttranslational regulatory mechanisms.
Pulp Healing and Regeneration

Differences between pulp repair and regeneration guide different strategic options. After mild carious dentin lesions, odontoblasts and Hoehl’s cells are implicated in the formation of reactionary dentin. Reparative dentin formation and/or pulp regeneration after partial degradation is under the control of pulp progenitors. A series of questions arise from recent researches on tissue engineering. In this series of questions, we compare the therapeutic potential of pluripotent embryonic and adult stem cells, both being used in cell-based dental therapies. Crucial questions arise on the origin of stem cells and the localization of niches of progenitors in adult teeth. Circulating progenitor cells may also be candidate for promoting pulp regeneration. Then, we focus on strategies allowing efficient progenitors recruitment. Along this line, we compare the potential of embryonic stem cells versus adult stem cells. Re-programming adult pulp cells to become induced pluripotent stem cells constitute another option. Genes, transcription factors and growth factors may be used to stimulate the differentiation cascade. Extracellular matrix molecules or some bioactive specific domains after enzymatic cleavage may also contribute to the formation of an artificial pulp and ultimately to its mineralization.
Wideband, Wide-Scan Planar Array of Connected Slots Loaded With Artificial Dielectric Superstrates

Microwave broadband wide-scan antenna arrays are typically implemented resorting to vertical arrangements of printed circuit boards (PCBs). Here, we propose a planar solution realized with a single multi-layer PCB, with consequent reduction in cost and complexity of the array. It consists of an array of connected slots backed by a metallic reflector and loaded with superstrates. Artificial dielectric layers (ADLs) are used in place of real dielectrics to realize the superstrates, as they are characterized by very low surface-wave losses. For the unit-cell design, we developed an analysis tool based on closed-form expressions and thus requiring minimal computational resources. Finite-array simulations are also performed by generalizing the analysis method to account for the truncation effects. The presence of the ADL superstrate allows reducing the distance between the array plane and the backing reflector while maintaining good matching performance. A realistic feed structure is also proposed, which consists of a microstrip line connected to a coaxial feed. Such a solution does not require balanced-to-unbalanced transitions, which often limit the achievable bandwidth. The proposed structure achieves in simulations more than an octave bandwidth (6.5-14.5 GHz), within a scanning range of ±50° in all azimuth planes.
Transparent $\hbox{SnO}_{2}$ Nanowire Electric-Double-Layer Transistors With Different Antimony Doping Levels

Transparent SnO<sub>2</sub> nanowire electric-double-layer (EDL) transistors with different antimony (Sb) doping levels are fabricated on transparent conducting glass substrates. The threshold voltage (<i>V</i><sub>th</sub>) can be effectively modulated by in situ Sb doping. Both enhancement mode and depletion mode are realized, and the <i>V</i><sub>th</sub> shift of the nanowire EDL transistors is estimated to be 0.41 V. All nanowire EDL transistors show good electrical characteristics with a high field-effect mobility (>; 100 cm<sup>2</sup>/V · s), a high drain-current on/off ratio (>; 8 × 10<sup>4</sup>), and a small subthreshold slope (<; 200 mV/dec). These transparent nanowire EDL transistors are promising for “see- through” nanoscale sensors.
Acute phase response and oxidative stress status in familial Mediterranean fever (FMF)

We aimed to determine acute phase response (APR) and oxidative stress in patients with familial Mediterranean fever (FMF) and compare these characteristics with those in healthy controls; 20 patients with FMF and 15 healthy controls were enrolled in the study. The erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), fibrinogen, and leukocyte levels were determined as markers of APR. Thiobarbituric acid reactive substances (TBARS), conjugated diene, and lipid hydroperoxide levels were measured as markers of lipid peroxidation. Carbonyl group and thiol (T-SH) levels were analyzed to determine the oxidative damage to proteins, and 8-hydroxy-2-deoxyguanosine (8-OHdG) was measured to reflect DNA oxidation. The erythrocyte glutathione (GSH) level, and glutathione peroxidase (GSH-Px), CuZn superoxide dismutase (CuZn SOD), and catalase activities were measured as markers of antioxidant status. Conjugated diene (p < 0.001) and carbonyl group (p < 0.05) levels were significantly higher and GSH-Px activity (p < 0.01) was significantly lower in FMF patients compared with controls. FMF patients in the attack period (n = 8) had significantly higher CRP, ESR, fibrinogen, and leukocyte levels (p < 0.001) than patients in the attack-free period (n = 12). The T-SH level (p < 0.05) was significantly higher and CuZn SOD activity was significantly lower (p < 0.05) in FMF patients in the attack period. The findings revealed upregulated APR during the attack period in FMF patients and enhanced oxidative stress in the FMF patients as compared to controls.
Expression of G Protein-Coupled Receptor 19 in Human Lung Cancer Cells Is Triggered by Entry into S-Phase and Supports G2–M Cell-Cycle Progression

It has long been known that G protein-coupled receptors (GPCR) are subject to illegitimate expression in tumor cells. Presumably, hijacking the normal physiologic functions of GPCRs contributes to all biologic capabilities acquired during tumorigenesis. Here, we searched for GPCRs that were expressed in lung cancer: the mRNA encoding orphan G protein-coupled receptor 19 (GPR19) was found frequently overexpressed in tissue samples obtained from patients with small cell lung cancer. Several observations indicate that overexpression of Gpr19 confers a specific advantage to lung cancer cells by accelerating transition through the cell-cycle. (i) Knockdown of Gpr19 mRNA by RNA interference reduced cell growth of human lung cancer cell lines. (ii) Cell-cycle progression through G2–M-phase was impaired in cells transfected with siRNAs directed against Gpr19 and this was associated with increased protein levels of cyclin B1 and phosphorylated histone H3. (iii) The expression levels of Gpr19 mRNA varied along the cell-cycle with a peak observed in S-phase. (iv) The putative control of Gpr19 expression by E2F transcription factors was verified by chromatin immunoprecipitation: antibodies directed against E2F-1 to -4 allowed for the recovery of the Gpr19 promoter. (v) Removal of E2F binding sites in the Gpr19 promoter diminished the expression of a luciferase reporter. (vi) E2f and Gpr19 expression correlated in lung cancer patient samples. To the best of knowledge, this is the first example of a GPCR showing cell-cycle-specific mRNA expression. Our data also validate GPR19 as a candidate target when overexpressed in lung cancer. Mol Cancer Res; 10(10); 1343–58. ©2012 AACR.
Gene expression and immune response kinetics using electroporation‐mediated DNA delivery to muscle

Injection of DNA encoding exogenic proteins into muscle tissue combined with electroporation often results in a transient increase of the encoded protein concentration in the muscle and the blood. The reduction is normally due to an immune response against the exogenic protein but other factors may also be involved. How various electroporation parameters affect the concentration kinetics of syngenic and exogenic proteins is studied in relation to immune response and muscle damage after electroporation‐mediated DNA transfer to muscle.
The 1990s Trade and Wages Debate in Retrospect

This paper revisits the trade and wages debate of the 1990s in the light of widespread concern that, contrary to the consensus from that debate, the costs of globalisation to lessâ€ skilled workers in developed countries have been an important cause of the recent rise of populism. The 1990s debate stimulated a new and now large field of economic research, but in hindsight it suffered from errors of omission on both sides, and from an academic perspective it ended prematurely. Even now, the available evidence does not permit any firm conclusion about the contribution of globalisation to the rise in inequality in developed countries over the past few decades. The economic consensus at the end of the debate also fostered unwarranted political complacency about the social costs of globalisation.
Clinical features and natural history of multiple system atrophy. An analysis of 100 cases.

The clinical features and natural history of 100 patients diagnosed as probable multiple system atrophy (MSA) are described. In all 14 (of 41 deceased) cases who underwent post-mortem examination of the brain, the diagnosis was confirmed pathologically, providing some validation of the clinical diagnostic criteria used. There were 67 men and 33 women. Median age at onset (at time of first reported symptom) was 53 (range 33-76) years. Autonomic symptoms were the initial feature in 41% of the patients, but had subsequently developed in 97% at latest follow-up. The most frequent autonomic symptom in men was impotence, and in women was urinary incontinence. Symptomatic orthostatic hypotension, although present in 68%, was severe in only 15% of patients. Parkinsonism was the initial feature in 46%, but had subsequently developed in 91% of subjects at latest follow-up. It was the predominant motor disorder [striatonigral degeneration (SND) type] in 82% of the patients, and was usually asymmetric (74%). Although akinesia and rigidity predominated, tremor was present at rest in 29% of patients, but in only 9% had a classical pill-rolling parkinsonian rest tremor been recorded. Twenty-nine percent of MSA patients had a good or excellent levodopa response at some stage. However, only 13% maintained this response. Prominent orofacial dyskinesias and dystonias occurred in a quarter of treated patients with MSA. Early onset (before age 49 years) MSA patients tended to have a good levodopa response. Cerebellar symptoms or signs were the only initial feature in 5%. Although subsequently developing in a further 47% of cases, in only 18% was a cerebellar syndrome the only (9%) or predominant (9%) motor disorder [olivopontocerebellar (OPCA) type]. Pyramidal involvement at latest follow-up was noted in 61% of all cases. In a further seven patients the initial features involved more than one system, and one other had presented as a parasomnia. Multiple system atrophy of the OPCA type most commonly presented with gait ataxia. Tremor, pyramidal signs and myoclonus were less common than in MSA of the SND type. Cerebellar signs were present in 42% of patients with MSA of the SND type and parkinsonian signs in 50% of patients with MSA of the OPCA type. Disease progression was faster than in idiopathic Parkinson's disease, so that > 40% of patients were markedly disabled or wheelchair bound within 5 years of onset of motor disturbance. Median survival of the whole group as calculated by Kaplan-Meier analysis was 9.5 years. (ABSTRACT TRUNCATED AT 250 WORDS)
Compressive estimation of a stochastic process with unknown autocorrelation function

In this paper, we study the prediction of a circularly symmetric zero-mean stationary Gaussian process from a window of observations consisting of finitely many samples. This is a prevalent problem in a wide range of applications in communication theory and signal processing. Due to stationarity, when the autocorrelation function or equivalently the power spectral density (PSD) of the process is available, the Minimum Mean Squared Error (MMSE) predictor is readily obtained. In particular, it is given by a linear operator that depends on autocorrelation of the process as well as the noise power in the observed samples. The prediction becomes, however, quite challenging when the PSD of the process is unknown. In this paper, we propose a blind predictor that does not require the a priori knowledge of the PSD of the process and compare its performance with that of an MMSE predictor that has a full knowledge of the PSD. To design such a blind predictor, we use the random spectral representation of a stationary Gaussian process. We apply the well-known atomic-norm minimization technique to the observed samples to obtain a discrete quantization of the underlying random spectrum, which we use to predict the process. Our simulation results show that this estimator has a good performance comparable with that of the MMSE estimator.