Miracle-dz/UniFAR-FTUs huggingface dataset:
Qualitative research in anesthesiology: An essential practice and need of the hour

1. Feliu M, Edwards Cl, Sudhakar S, Mcdougald C, raynor r, Johnson S, et al. Neuropsychological effects and attitudes in patients following electroconvulsive therapy. Neuropsychiatr dis treat 2008;4:613-7. 2. Uppal V, dourish J, Macfarlane a. anaesthesia for electroconvulsive therapy. Contin Educ anaesth Crit Care Pain 2010;10:192-6. 3. Ding Z, White PF. Anesthesia for electroconvulsive therapy. anesth analg 2002;94:1351-64. 4. Yalcin S, Aydoğan H, Selek S, Kucuk A, Yuce HH, Karababa F, et al. Ketofol in electroconvulsive therapy anesthesia: two stones for one bird. J anesth 2012;26:562-7. 5. Dogan Z, Senoglu N, Yildiz H, Coskuner I, Ugur N, Biter E, et al. Comparison of enflurane and propofol in electroconvulsive therapy, a randomized crossover open preliminary study on seizure duration and anaesthetic recovery. rev Bras anestesiol 2011;61:582-90. 6. Geretsegger C, Nickel M, Judendorfer B, rochowanski E, Novak E, aichhorn W. Propofol and methohexital as anesthetic agents for electroconvulsive therapy: a randomized, double-blind comparison of electroconvulsive therapy seizure quality, therapeutic efficacy, and cognitive performance. J ECt 2007;23:239-43. 7. Kranaster l, Kammerer-Ciernioch J, Hoyer C, Sartorius a. Clinically favourable effects of ketamine as an anaesthetic for electroconvulsive therapy: a retrospective study. Eur arch Psychiatry Clin Neurosci 2011;261:575-82. 8. rosa Ma, rosa Mo, Belegarde iM, Bueno Cr, Fregni F. recovery after ECt: Comparison of propofol, etomidate and thiopental. rev Bras Psiquiatr 2008;30:149-51. 9. Erdogan Kayhan G, Yucel A, Colak YZ, Ozgul U, Yologlu S, Karlıdag R, et al. Ketofol (mixture of ketamine and propofol) administration in electroconvulsive therapy. anaesth intensive Care 2012;40:305-10. 10. Gregory-roberts EM, Naismith Sl, Cullen KM, Hickie iB. Electroconvulsive therapy-induced persistent retrograde amnesia: Could it be minimised by ketamine or other pharmacological approaches? J affect disord 2010;126:39-45. 11. MacPherson rd, loo CK. Cognitive impairment following electroconvulsive therapy-does the choice of anesthetic agent makes a difference? J ECt 2008;24:52-6. 12. okamoto N, Nakai t, Sakamoto K, Nagafusa Y, Higuchi t, Nishikawa t. rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: Comparing ketamine and propofol anesthesia. J ECt 2010;26:223-7. 13. Mahajan r, Swarnkar N, Ghosh a. Comparison of ketamine and fentanyl with propofol in total intravenous anesthesia: a double blind randomized clinical trial. internet J anesthesiol 2010; 23. doi: 10.5580/d50 14. Wang X, Chen Y, Zhou X, Liu F, Zhang T, Zhang C. Effects of propofol and ketamine as combined anesthesia for electroconvulsive therapy in patients with depressive disorder. J ECt 2012;28:128-32.
Collaborative Learning in a Web-mediated Environment: A study of communicative practices

New opportunities for conceptualising, designing and facilitating collaborative learning are rapidly expanding with the technological innovations and proliferation of web-mediated learning and teaching. By enabling social interactions via an electronic medium, web technologies are not only expanding but also transforming the social interaction space of collaborative learning. This paper explores collaborative learning viewed from these social interaction processes. More specifically, the paper applies a Communicative Model of Collaborative Learning to make sense of students' interactions in a management subject taught in a combined face-to-face and web-mediated mode. This model provides a methodological instrument for the analysis of communicative practices in concrete learning processes. By analysing the empirical data from linguistic interactions among students, the paper investigates not only what these interactions mean but also what they produce in a particular learning situation and how they affect learning. In particular, the paper investigates processes of knowledge co-creation that are integral to the development of capabilities for life-long learning.
Guided visibility sampling

This paper addresses the problem of computing the triangles visible from a region in space. The proposed aggressive visibility solution is based on stochastic ray shooting and can take any triangular model as input. We do not rely on connectivity information, volumetric occluders, or the availability of large occluders, and can therefore process any given input scene. The proposed algorithm is practically memoryless, thereby alleviating the large memory consumption problems prevalent in several previous algorithms. The strategy of our algorithm is to use ray mutations in ray space to cast rays that are likely to sample new triangles. Our algorithm improves the sampling efficiency of previous work by over two orders of magnitude.
Validación del Cuestionario de Conflicto Interpersonal en el Trabajo (CIT) en empleados españoles

Resumen El presente trabajo tiene como objetivo la validación a la población española de un instrumento de medida de conflictos interpersonales en el trabajo (CIT) en sus dos dimensiones (conflicto de tareas vs. conflicto de relaciones). Para ello, realizamos dos tipos de análisis con una muestra de 209 trabajadores provenientes de diferentes organizaciones españolas. El objetivo del primero fue la confirmación de la estructura factorial del cuestionario (AFC) y la demostración de su fiabilidad. El objetivo del segundo fue demostrar la validez predictiva de ambas dimensiones. La versión en español de conflictos interpersonales en el trabajo (CIT) mostró niveles aceptables de consistencia interna. Los resultados mostraron un mejor ajuste del modelo ante la existencia de una estructura bifactorial (conflicto de tareas y conflicto de relaciones) frente a un modelo unifactorial (conflicto interpersonal general) siendo diferente la relación entre ambos tipos de conflictos y las variables consecuentes de bienestar psicológico y clima de apoyo, respectivamente. Estos hallazgos apoyan la validez de constructo y la fiabilidad de la versión en español de conflictos interpersonales en el trabajo (CIT) para evaluar los distintos tipos de conflictos en muestras de habla hispana.
Resilience associated with mental health problems among methadone maintenance treatment patients in Guangzhou, China

ABSTRACT A considerable proportion of methadone maintenance treatment (MMT) clients have experienced mental health problems (e.g., depression and anxiety), and poor mental health status is associated with HIV-related risk behaviors and treatment drop-out. Resilience is known to be a protective factor for mental health problems but is not studied among MMT clients in China. This study aimed to explore the relationship between resilience and mental health problems (depression, anxiety and stress) among clients of community-based MMT clinics in China. A total of 208 MMT clients completed the face-to-face interview conducted at 4 of 11 MMT clinics in Guangzhou. The Chinese short version of Depression Anxiety Stress Scale (DASS-21) was used to assess the presence of depressive, anxiety and stress symptoms, and the Connor–Davidson Resilience Scale (CD-RISC) was used to measure resilience. Logistic regression models were fit in data analyses. Of all participants, 12.8%, 19.5% and 8.3% had depression, anxiety and stress, respectively. The mean resilience score was 57.6 (SD = 15.9). In the univariate analyses, resilience was negatively associated with two studied mental health problems (depression and anxiety, ORu = 0.96 and 0.96, p < .01). In multivariate models adjusting for both background and other psycho-social factors, resilience was independently associated with probable depression (ORa = 0.97, 95% CI: 0.93–0.99) and anxiety (ORa = 0.96, 95% CI: 0.94–0.99). Resilience was independently associated with depression and anxiety. As resilience is changeable, interventions targeting mental health problems of MMT users should consider resilience as an important part in the designing of such interventions.
Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1)

Protein kinase Cι (PKCι) is activated by oncogenic Ras proteins and is required for K-Ras–induced transformation and colonic carcinogenesis in vivo. However, the role of PKCι in signal transduction and oncogenesis is not clear. We recently identified a small molecule, designated 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1), that can selectively kill K-Ras mutant cancer cells and induce abnormal nuclear aggregation of PKCι in sensitive cells but not in resistant cells. To determine the causes and biological consequences of PKCι aggregates in the nucleus, we analyzed the effect of oncrasin-1 on proteins involved in DNA repair and RNA processing. Our results showed that oncrasin-1 treatment led to coaggregation of PKCι and splicing factors into megaspliceosomes but had no obvious effects on the DNA repair molecule Rad51. Moreover, oncrasin-1 treatment suppressed the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells but not in resistant cells, suggesting that suppression of RNA transcription is a major effect of oncrasin-1 treatment. Studies with cultured cells or with recombinant proteins showed that oncrasin-1 can disrupt the interaction of PKCι and cyclin-dependent protein kinase 9/cyclin T1 complex, which is known to phosphorylate the largest subunit of RNA polymerase II and is required for RNA transcription. Together, our results suggest that oncrasin-1 suppresses the function of RNA processing machinery and that PKCι might be involved in the biological function of RNA processing complexes. [Mol Cancer Ther 2009;8(2):441–8]
Incorporation and Mechanical Solidarity in an Underground Coal Mine

In this article we illustrate the concern with mechanical solidarity exhibited by work groups within a dangerous work setting. Building upon the notions of Ralph Turner and Louis Zurcher, the argument is made that groups which must continually deal with potential disaster will manifest mechanical solidarity as the dominant form of social integration. In the underground coal mine, games and dramatic performances which subvert outside behavioral expectations are utilized to emphasize the "different world" context of the work setting. Deviant from dominant cultural norms, these games serve as powerful mechanisms for the direct bonding of individual and group.
Follow‐up insights on rapid educational acceleration

Too little is known about what happens, when they grow up, to youths who reason extremely well mathematically. Few tell their story to specialists in education of the gifted, either in writing or orally. Julian Stanley brought two successful former “radical accelerants” to the November 1993 annual meeting of the National Association for Gifted Children in Atlanta and also provided some information about 12 other mathematically precocious youths. Jane C. Charlton and Donald M. Marolf, the two young adults featured, told the symposium audience about themselves and answered questions. They were amazingly frank, insightful, and humorous about their lives thus far. Both are convinced, and are convincing, that rapid progress through school grades all the way to the Ph.D. degree is the nearly optimal way for persons like themselves to enrich their education and prepare for adulthood. All three speakers agreed, however, that extremely fast educational advancement might not be the ideal curriculum path for some other equally capable boys and girls.
Evaluating Executive Leadership Programs

As executive leadership development programs become more informal and experiential, traditional evaluation models of learning transfer based on fixed objectives do not capture emerging program outcomes. What is needed is a more robust approach for increasingly complex environments that looks at open objectives and changes that have occurred that affect both the individual and the organization. This article presents an evaluation model based on a Theory of Change approach that identifies critical incidents of new behavior and explores changes at individual and organizational levels. This evaluation model relies on repositioning management learning in leadership development programs and incorporates theories of action, workplace, and organizational learning. Two case studies of executive leadership development in the United States and Europe demonstrate the model’s usefulness. Both studies explore emerging program outcomes using in-depth interviews with participants in the leadership programs. Key stakeholders include individuals who design and deliver leadership development programs as well as the leaders who must make difficult decision regarding where to invest limited development dollars. In addition, evaluators of those programs as well as scholars of both evaluation and of leadership development will find this approach of interest. The approach is useful both for guiding practice and for developing knowledge about what types of learning occur in these programs and what persists.
Code Layout Optimization for Defensiveness and Politeness in Shared Cache

Code layout optimization seeks to reorganize the instructions of a program to better utilize the cache. On multicore, parallel executions improve the throughput but may significantly increase the cache contention, because the co-run programs share the cache and in the case of hyper-threading, the instruction cache. In this paper, we extend the reference affinity model for use in whole-program code layout optimization. We also implement the temporal relation graph (TRG) model used in prior work for comparison. For code reorganization, we have developed both function reordering and inter-procedural basic-block reordering. We implement the two models and the two transformations in the LLVM compiler. Experimental results on a set of benchmarks show frequently 20% to 50% reduction in instruction cache misses. By better utilizing the shared cache, the new techniques magnify the throughput improvement of hyper-threading by 8%.
Smoothing profiles with sliding windows: better to wear a hat!

A general way to analyze sequences is to turn them into lists of position-dependent numerical values, the graphical representation of which provides a sequence profile suitable for visual inspection and «pattern recognition». We examine here the merit of the «triangular» window, which consists of associating linearly decreasing weights with the positions starting from the center («hat» average)
Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease

Kidneys are enlarged by aberrant proliferation of tubule epithelial cells leading to the formation of numerous cysts, nephron loss, and interstitial fibrosis in polycystic kidney disease (PKD). Pioglitazone (PIO), a PPAR-γ agonist, decreased cell proliferation, interstitial fibrosis, and inflammation, and ameliorated PKD progression in PCK rats (Am. J. Physiol.-Renal, 2011). To explore genetic mechanisms involved, changes in global gene expression were analyzed. By Gene Set Enrichment Analysis of 30655 genes, 13 of the top 20 downregulated gene ontology biological process gene sets and six of the top 20 curated gene set canonical pathways identified to be downregulated by PIOtreatment were related to cell cycle and proliferation, including EGF, PDGF and JNK pathways. Their relevant pathways were identified using the Kyoto Encyclopedia of Gene and Genomes database. Stearoyl-coenzyme A desaturase 1 is a key enzyme in fatty acid metabolism found in the top 5 genes downregulated by PIO treatment. Immunohistochemical analysis revealed that the gene product of this enzyme was highly expressed in PCK kidneys and decreased by PIO. These data show that PIO alters the expression of genes involved in cell cycle progression, cell proliferation, and fatty acid metabolism.
Bayesian multisensory perception

We investigate a solution to the problem of multi-sensor perception by formulating it in the framework of Bayesian model selection. Humans robustly integrate and segregate multi-sensory data as appropriate, but previous theoretical work has focused largely on purely integrative cases, leaving segregation unaccounted for and unexploited by machine perception systems. We illustrate a unifying, principled Bayesian solution which accounts for both integration and segregation by reasoning explicitly about data association in a probabilistic framework. Unsupervised learning of such a model with EM is illustrated for a real world audio-visual application.
Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan

Alterations in cellular cholesterol synthesis or content in cultured neurons affect the cleavage of amyloid precursor protein to amyloidogenic Aβ40 and Aβ42 peptides characteristic of Alzheimer's disease. To determine whether a decrease in cholesterol synthesis affects amyloid precursor protein processing in vivo, we crossed cholesterol 24-hydroxylase knockout mice, which exhibit a 50% reduction in brain sterol synthesis, with transgenic mice [B6.Cg-Tg(APPswe, PSEN1E9)85Dbo/J] that develop Alzheimer's disease-like pathology. Amyloid precursor protein expression and amyloid plaque deposition in the cortex and hippocampus of male and female Alzheimer's disease mice between the ages of 3 to 15 months were similar in the presence and absence of cholesterol 24-hydroxylase. A modest but statistically significant decline in insoluble Aβ42 peptide levels was detected in the hippocampus of 12-month-old knockout/Alzheimer's disease males. The levels of insoluble Aβ40 and Aβ42 peptides in 15-month-old knockout/Alzheimer's disease females were also reduced slightly. Although amyloid plaque accumulation did not affect brain sterol or fatty acid synthesis rates in 24-hydroxylase WT or knockout mice, loss of one or both cholesterol 24-hydroxylase alleles increased longevity in Alzheimer's disease mice. These studies suggest that reducing de novo cholesterol synthesis in the brain will not substantially alter the course of Alzheimer's disease, but may confer a survival advantage.
Sequence, Structural and Expression Divergence of Duplicate Genes in the Bovine Genome

Gene duplication is a widespread phenomenon in genome evolution, and it has been proposed to serve as an engine of evolutionary innovation. In the present study, we performed the first comprehensive analysis of duplicate genes in the bovine genome. A total of 3131 putative duplicated gene pairs were identified, including 712 cattle-specific duplicate gene pairs unevenly distributed across the genome, which are significantly enriched for specific biological functions including immunity, growth, digestion, reproduction, embryonic development, inflammatory response, and defense response to bacterium. Around 97.1% (87.8%) of (cattle-specific) duplicate gene pairs were found to have distinct exon-intron structures. Analysis of gene expression by RNA-Seq and sequence divergence (synonymous or non-synonymous) revealed that expression divergence is correlated with sequence divergence, as has been previously observed in other species. This analysis also led to the identification of a subset of cattle-specific duplicate gene pairs exhibiting very high expression divergence. Interestingly, further investigation revealed a significant relationship between structural and expression divergence while controlling for the effect of synonymous sequence divergence. Together these results provide further insight into duplicate gene sequence and expression divergence in cattle, and their potential contributions to phenotypic divergence.
The effects of cultural types on perceptions of justice and gender inequity in the workplace

This study uses the horizontal and vertical distinction within individualism and collectivism as a theoretical framework to predict differences in employee perceptions of organizational justice and gender inequity. In this study we survey 514 solicitors working in law firms in Hong Kong. Results of regression analysis indicated that horizontal-collectivism (HC) had a significant positive effect on procedural justice and vertical-individualism (VI) had a significant and positive effect on distributive justice. Vertical- and horizontal-individualism (VI and HI) had positive and significant effects on both perceived gender bias and perceived gender discrimination. We discuss the theoretical and practical implications of our findings and suggest future research directions.
Abnormal Behavior Detection via Sparse Reconstruction Analysis of Trajectory

This paper proposes a new method for abnormal behavior detection in surveillance videos via sparse reconstruction analysis. The motion trajectories of objects are firstly defined as fixed-length parametric vectors based on approximating cubic B-spline curves. Then the vectors are classified as behavior patterns and finally distinguished between normal and abnormal behaviors based on sparse reconstruction analysis, in which a classifier is constructed with sparse linear reconstruction coefficients by computing L1-norm minimization and sparse reconstruction residuals learning from labeled training samples. Experimental results on public dataset show the effectiveness of the proposed approach.
Eurographics/ Ieee-vgtc Symposium on Visualization 2010 Image-based Edge Bundles: Simplified Visualization of Large Graphs

We present a new approach aimed at understanding the structure of connections in edge-bundling layouts. We combine the advantages of edge bundles with a bundle-centric simplified visual representation of a graph's structure. For this, we first compute a hierarchical edge clustering of a given graph layout which groups similar edges together. Next, we render clusters at a user-selected level of detail using a new image-based technique that combines distance-based splatting and shape skeletonization. The overall result displays a given graph as a small set of overlapping shaded edge bundles. Luminance, saturation, hue, and shading encode edge density, edge types, and edge similarity. Finally, we add brushing and a new type of semantic lens to help navigation where local structures overlap. We illustrate the proposed method on several real-world graph datasets.
Isolation of the yeast nuclear pore complex

Nuclear pore complexes (NPCs) have been isolated from the yeast Saccharomyces. Negative stain electron microscopy of the isolated NPCs and subsequent image reconstruction revealed the octagonal symmetry and many of the ultrastructural features characteristic of vertebrate NPCs. The overall dimensions of the yeast NPC, both in its isolated form as well as in situ, are smaller than its vertebrate counterpart. However, the diameter of the central structures are similar. The isolated yeast NPC has a sedimentation coefficient of approximately 310 S and an M(r) of approximately 66 MD. It retains all but one of the eight known NPC proteins. In addition it contains as many as 80 uncharacterized proteins that are candidate NPC proteins.