Miracle-dz/UniFAR-FTUs huggingface dataset:
Ala variant in sulphonylurea receptor gene ABCC 8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients

1. Anhui Biomedical Institute, Anhui Medical University, Hefei, China 2. Division of Endocrinology, the Second Hospital, Harbin Medical University, Harbin, China 3. Division of Endocrinology, the First Hospital, Harbin Medical University, Harbin, China 4. Tianjin Medical University Metabolic Hospital, Tianjin, China 5. Division of Endocrinology, Tongren Hospital, Capital Medical University, Beijing, China 6. Division of Endocrinology, the First Hefei People Hospital, Hefei, China 7. The Mary Ann and J. Milburn Smith Child Health Research Program, Children’s Memorial Hospital and Children’s Memorial Research Center, Chicago, IL USA;
Espectros de peligro sísmico uniforme

Los espectros de diseno basados en formas que se escalan con la aceleracion pico del suelo conducen a una distribucion no uniforme del peligro a lo largo del espectro y por tanto a un nivel de riesgo diferente entre edificaciones de distinta altura. En este trabajo se presenta una metodologia para estimar la aceleracion y las ordenadas espectrales asociados a un nivel de excedencia uniforme a lo largo del espectro. Se analizo la sismicidad del Peru, se actualizaron las fuentes sismicas propuestas en trabajo anteriores, se empleo la magnitud momento (Mw) y se uso por primera vez para todo el Pais una ley de atenuacion que distinga sismos de subduccion de interfase e intraplaca. Como resultado, se obtuvieron mapas de distribucion de aceleraciones y ordenadas espectrales para todo el Pais correspondientes a un periodo de retorno de 475 anos. Los calculos se hicieron con un programa de computo desarrollado como parte de este trabajo. Las aceleraciones obtenidas en roca presentan valores inferiores a los obtenidos en 1993 por Castillo y Alva hasta en 10%, salvo en la zona de Piura y Tumbes donde los valores son menores hasta en 30%. Se encontro que los valores del factor de amplificacion espectral para 0,2seg tienen diferencias pequenas (3%) a lo largo del territorio, mientras que para 1,0seg los valores aumentan de oeste a este de manera significativa (35% en Iquitos). Esto muestra la necesidad de desarrollar espectros de peligro uniforme propios de cada zona sismica del pais.
Structure-Function Relationships in the HAMP and Proximal Signaling Domains of the Aerotaxis Receptor Aer

ABSTRACT Aer, the Escherichia coli aerotaxis receptor, faces the cytoplasm, where the PAS (Per-ARNT-Sim)-flavin adenine dinucleotide (FAD) domain senses redox changes in the electron transport system or cytoplasm. PAS-FAD interacts with a HAMP (histidine kinase, adenylyl cyclase, methyl-accepting protein, and phosphatase) domain to form an input-output module for Aer signaling. In this study, the structure of the Aer HAMP and proximal signaling domains was probed to elucidate structure-function relationships important for signaling. Aer residues 210 to 290 were individually replaced with cysteine and then cross-linked in vivo. The results confirmed that the Aer HAMP domain is composed of two α-helices separated by a structured loop. The proximal signaling domain consisted of two α-helices separated by a short undetermined structure. The Af1503 HAMP domain from Archaeoglobus fulgidus was recently shown to be a four-helix bundle. To test whether the Af1503 HAMP domain is a prototype for the Aer HAMP domain, the latter was modeled using coordinates from Af1503. Several findings supported the hypothesis that Aer has a four-helix HAMP structure: (i) cross-linking independently identified the same residues at the dimer interface that were predicted by the model, (ii) the rate of cross-linking for residue pairs was inversely proportional to the β-carbon distances measured on the model, and (iii) clockwise lesions that were not contiguous in the linear Aer sequence were clustered in one region in the folded HAMP model, defining a potential site of PAS-HAMP interaction during signaling. In silico modeling of mutant Aer proteins indicated that the four-helix HAMP structure was important for Aer stability or maturation. The significance of the HAMP and proximal signaling domain structure for signal transduction is discussed.
A Double-Layer Transmitarray Antenna Using Malta Crosses With Vias

A novel transmitarray element consisting of only two layers of modified Malta crosses printed on a dielectric substrate is proposed, and vias are employed to augment the transmission magnitude and enhance its phase shift range. A prototype transmitarray with a circular aperture of 338 mm in diameter is then designed, fabricated, and tested to validate the proposed design. The simulation and measurement results show good radiation characteristics with measured gain of 33.0 dBi at 20 GHz and aperture efficiency of 40%. The proposed element considerably simplifies the complexity of a transmitarray, reducing its thickness, mass, and cost.
Prevalence and characteristics of OSAFED syndrome in atrial fibrillation primary care patients.

BACKGROUND Atrial fibrillation (AF) constitutes the most prevalent arrhythmia, affecting up-to 2% of the general population. Apart from well-established risk factors that increase the odds for the development of AF, e.g. age or arterial hypertension, recent analyses indicate that obstructive sleep apnoea (OSA) may independently, negatively modify the arrhythmia occur-rence profile. Concurrently, erectile dysfunction (ED) is a commonly neglected, potent marker of cardiovascular risk, which considerably worsens men's psychological state. Unrecognised or untreated ED results in substantial deterioration of the patient's therapeutic programme adherence. Because AF, OSA, and ED share multiple risk factors and clinical consequences, in 2013 the concept of their frequent concurrence - OSAFED syndrome - was proposed. AIM The aim of the study was to evaluate the prevalence of OSAFED patients with AF in primary care practice. METHODS Retrospective analysis was carried out of data from primary care physician charts (NZOZ Esculap Gniewkowo, central Poland) including 1372 men aged 40-65 years. The primary goal was to determine the diagnosis of paroxysmal and/or perma-nent AF, which was followed by sleep apnoea screening (polygraphy) and erectile function evaluation (IIED-5 questionnaire). RESULTS Twenty-one (1.5%) patients with documented AF were identified. Based on the sleep-polygraphic studies, 14 (67%) of them had confirmation of OSA with mean apnoea-hypopnea index (AHI) equal to 27.5 ± 17.1. Furthermore, 11 (52%) patients met the OSAFED syndrome criteria. Patients with OSAFED syndrome had a mean score in IIEF-5 of 11.6 ± 3.5. The OSAFED-patients who were not diagnosed with all the of the syndrome components prior to the study-enrolment were characterised by substantially lower fat excess compared to their counterparts with already established OSAFED (body mass index: 30.1 ± 4.9 vs. 37.7 ± 3.9 kg/m², respectively, p = 0.03). CONCLUSIONS Frequently coexisting OSAFED syndrome components in all AF patients from the primary care setting should encourage a more active search for OSA and ED in patients with any documented form of AF. Most of the studied patients did not have the diagnosis of OSA nor ED done prior to participation in the study.
Nonlinear Material Based All-Optical Parallel Subtraction Scheme: an Implementation

Non-linear material based all-optical switching mechanism is utilized here to implement the all-optical paral- lel subtraction scheme. Optical tree architectures here convert analog optical signal to the corresponding digital one. A two bit all-optical binary parallel subtractor has been proposed and which may be elevated to a higher bit parallel subtractor in course using all-optical half-subtractor and a full-subtractor. These are constructed by a composite slab of linear medium (LM) and non-linear medium (NLM) and it is the building block of our proposed subtructor circuit. These circuits are all-optical and fully parallel in nature. It can also gear up to the highest ability of optical performance in high-speed all-optical computing system.
User friendly podalic interface for light weighted wearable robot arm

We previously proposed a wearable robot arm named Assist Oriented Arm, that solved weight and safety problems of the existing wearable robot arms. The previous user interface of AOA was consisted of multi-button switches. However, the previous version did not satisfy the users due to its complexity of operations. To solve this problem, in this paper, we propose two types of new interface of AOA: using foot pose and using great toe operation. From the experimental results, the user interface using foot pose is better than the one using great toe in terms of their operability.
CINTIL DependencyBank PREMIUM - A Corpus of Grammatical Dependencies for Portuguese

This paper presents a new linguistic resource for the study and computational processing of Portuguese. CINTIL DependencyBank PREMIUM is a corpus of Portuguese news text, accurately manually annotated with a wide range of linguistic information (morpho-syntax, named-entities, syntactic function and semantic roles), making it an invaluable resource specially for the development and evaluation of data-driven natural language processing tools. The corpus is under active development, reaching 4,000 sentences in its current version. The paper also reports on the training and evaluation of a dependency parser over this corpus. CINTIL DependencyBank PREMIUM is freely-available for research purposes through META-SHARE.
Feature Extraction and Classification of Electric Power Equipment Images Based on Corner Invariant Moments

Feature extraction and accurate classification of electric power equipment, help to improve the automation and intelligent level of power system management. Aiming at the problems that applying Hu invariant moments to extract image feature computes large and applying corner vector to match has too dimensions, this paper presented Harris corner invariant moments algorithm. This algorithm only calculates corner coordinates other than the entire image coordinates, so can change the point feature into feature vectors, and reduce the corner matching dimensions. Combined with the SVM (Support Vector Machine) classification method, we conducted a classification for a large number of electrical equipment images, and the result shows that using Harris corner invariant moments algorithm to extract invariant moments, and classifying by these invariant moments can achieve better classification accuracy.
Chemical de‐O‐glycosylation of glycoproteins for application in LC‐based proteomics

We describe a cyclic on‐column procedure for the sequential degradation of complex O‐glycans on proteins or peptides by periodate oxidation of sugars and cleavage of oxidation products by elimination. Desialylated glycoproteins were immobilized to alkali‐stable, reversed‐phase Poros 20 beads followed by two degradation cycles and the eluted apoproteins were either separated by SDS gel electrophoresis or digested with trypsin prior to LC/ESI‐MS. We demonstrate on the peptide and protein level that even complex glycan moieties are removed under mild conditions with only minimal effects on structural integrity of the peptide core by fragmentation, dehydration or by racemization of the Lys/Arg residues. The protocol is applicable on gel‐immobilized glycoproteins after SDS gel electrophoresis. Conversion of O‐glycoproteins into their corresponding apoproteins should result in facilitated accessibility of tryptic cleavage sites, increase the numbers of peptide fragments, and accordingly enhance protein coverage and identification rates within the subproteome of mucin‐type O‐glycoproteins.
Hypertension in relation to nitric oxide, asymmetric dimethylarginine, and inflammation: different patterns in heart transplant recipients and individuals with essential hypertension

Background. Most heart transplant (HTx) recipients develop hypertension, characterized by increased peripheral vascular tone and endothelial dysfunction. Reduced levels of nitric oxide (NO) have been found in essential hypertension, and herein we investigated the possible role of altered concentrations of NO in posttransplant hypertension. Methods. Plasma levels of the NO-derived end products NO2-+NO3-, the endogenous inhibitor of NO synthase asymmetric dimethylarginine (ADMA), and the inflammatory cytokine tumor necrosis factor (TNF)-&agr; were examined in 65 stable hypertensive long-term (6 years [range 1–13]) survivors of HTx. HTx recipients were compared with 39 individuals with essential hypertension and 25 normotensive controls. Results. Hypertensive HTx recipients had raised NO2-+NO3- levels in plasma, positively correlated with 24-hour mean blood pressure (BP). In contrast, individuals with essential hypertension had decreased NO2-+NO3- concentration comparing controls, inversely correlated with 24-hour mean BP. Moreover, although TNF-&agr; levels were significantly raised in HTx recipients compared with both healthy controls and individuals with essential hypertension, it was positively correlated to 24-hour BP and NO2-+NO3-. Although only a slight increase was found in essential hypertension, no correlations were found in these nontransplant individuals. Finally, although asymmetric dimethylarginine (ADMA) tended to be raised in essential hypertension, this endogenous nitric oxide synthase (NOS) inhibitor was significantly decreased in HTx recipients compared with normotensive controls. Conclusion. Our findings suggest that different mechanisms may be operating in the pathogenesis of posttransplant compared with essential hypertension, with persistent inflammation, raised NO2-+NO3-, and decreased ADMA levels characterizing the former group.
A Study of Annoyance Due to Low Frequency Noise in the Home

A survey of complaints of low frequency noise was followed by noise measurements in complainants' homes. The survey showed that annoyance was greatest in the late evening and early morning, leading to health problems in some cases. Measurements in the home indicated that the low frequencies at about the I.S. O. threshold level were capable of causing annoyance, especially when the noise fluctuated in level. This sometimes occurred due to a beat between two nearby components. Conventional, dB(A) based, methods of assessing annoyance fail when applied to low frequency noise.
Adenovirus vector-mediated perforin expression driven by a glucocorticoid-inducible promoter inhibits tumor growth in vivo.

To evaluate the concept that in vivo transfer of perforin complementary DNA (cDNA) will suppress tumor growth, we constructed an adenovirus vector (AdGRE.PFP) carrying perforin cDNA driven by the glucocorticoid response element (GRE) promoter. We infected A549 lung carcinoma cells with this vector in vitro and in vivo, and evaluated cell growth over time. In the presence of dexamethasone, in vitro infection of A549 cells with the AdGRE.PFP vector yielded perforin messenger RNA (mRNA) transcripts and effectively suppressed A549 cell growth. In accord with these in vitro observations, administration of dexamethasone following direct injection of AdGRE. PFP into established subcutaneous A549 tumors in nude mice resulted in a marked reduction in tumor growth as compared with AdGRE.PFP infection without dexamethasone or with dexamethasone alone. These observations suggest that regulable, adenovirus-mediated gene expression of perforin cDNA may have potential as a strategy for local control of tumor cell growth.
Health risk behaviors in family caregivers during patients' stay in intensive care units: a pilot analysis.

BACKGROUND Studies of family caregivers of the critically ill have mainly focused on the psychological impact of the patients' stay in the intensive care unit and related stress. Despite known associations between stress and physical health, limited attention has been paid to the need to promote and maintain physical health in these caregivers. OBJECTIVE To explore how family caregivers' health risk behaviors are associated with patients' preexisting care needs and the caregivers' depressive symptoms and burden. METHODS During the intensive-care-unit stay of critically ill patients (who required mechanical ventilation for ≥4 days), 50 family caregivers were surveyed to determine the caregivers' depressive symptoms, burden, and health risk behaviors. Data were also collected on patients' care needs before admission to the intensive care unit. RESULTS One or more health risk behaviors were reported by 94% of family caregivers. More than 90% of caregivers reported depressive symptoms above the score indicating risk for clinical depression. A high level of burden was reported by 36% of caregivers. More health risk behaviors were associated with higher scores of depressive symptoms and burden (P < .001 for both). Caregivers' responses did not differ according to patients' preexisting care needs. CONCLUSION Health risk behaviors of family caregivers are associated with greater perceptions of burden and/or depressive symptoms but not with patients' care needs before admission to the intensive care unit.
A 103.125-Gb/s Reverse Gearbox IC in 40-nm CMOS for Supporting Legacy 10- and 40-GbE Links

This paper presents the first 103.125-Gb/s multilink gearbox (MLG) IC, which facilitates the transport of independent 10- and 40-GbE signals to <inline-formula> <tex-math notation="LaTeX">$4 \times 25.78$ </tex-math></inline-formula> Gb/s physical layers, such as 100GBASE-xR4. The IC consumes only 1.37 W while implementing complicated reverse gearbox functionality. The measured TX jitter from 10- and 25-G lanes is 0.407 and 0.448 ps<sub>rms</sub>, respectively. The measured input sensitivities for a BER of <inline-formula> <tex-math notation="LaTeX">$10^{\mathrm {-12}}$ </tex-math></inline-formula> of the 10- and 25-G RXs are 20 and 42 mV<sub>ppd</sub>, respectively. The proposed gearbox IC, fabricated in a 40-nm CMOS process, occupies <inline-formula> <tex-math notation="LaTeX">$3.7 \times 3.4$ </tex-math></inline-formula> mm<sup>2</sup>. The power consumption of RX and TX in a 25-G interface is 50.9 and 52 mW, respectively, and those of a 10-G interface are 29 and 24.4 mW, respectively. MLG functionality is verified using embedded self-test logics.
Boosted Metric Learning for Efficient Identity-Based Face Retrieval

This paper presents MLBoost, an efficient method for learning to compare face signatures , and shows its application to the hierarchical organization of large face databases. More precisely, the proposed metric learning (ML) algorithm is based on boosting so that the metric is learned iteratively by combining several weak metrics. Boosting allows our method to be free of any hyper-parameters (no cross-validation required) and to be robust with respect to overfitting. This MLBoost algorithm can be trained from constraints involving two pairs of vectors (quadruplets) with a quadratic complexity. The paper also shows how it can be included in a semi-supervised hierarchical clustering framework adapted to identity based face search. Our approach is validated on a benchmark relying on the Labelled Faces in the Wild (LFW) dataset supplemented with 1M face distractors.
Substance Use and Violence Among Youth: A Daily Calendar Analysis

Background: While researchers have identified factors that contribute to youth violence, less is known about the details of violent incidents. In addition, substance use has been linked to youth violence; however, little is known about actual substance use on days in which violence occurs. Objective: This study examined reasons for peer violence and the association between substance use and violence using daily calendar-based analyses among at-risk urban youth. Methods: Data were collected from Emergency Department (ED) patients (ages 14–24; n = 599; 59% male, 65% African American) who screened positive for substance use in the past 6 months. Daily data regarding past 30-day substance use and violence and reasons for violent incidents were obtained via semi-structured interviews. Multi-level multinomial regression models were conducted to test the associations between substance use and peer violence incidents (i.e., none, moderate and severe). Results: Conflict over ‘personal belongings’ was a common reason for violence among males; ‘jealousy’/‘rumors’ were common reasons among females. Moderate victimization was more likely to be reported on days in which participants reported alcohol and cocaine use. Severe victimization was more likely to be reported on days in which participants reported alcohol use. Moderate or severe aggression was more likely to be reported on days in which participants reported alcohol and non-medical sedative use. Conclusions: Results suggest that youth violence prevention that addresses differential reasons for violence among males and females as well as substance use would be beneficial.
Endolaryngeal jet ventilation: A 10‐year review

Jet ventilation for microsurgery of the larynx has been in common use at our institution since 1978. There were 942 cases performed, with ages ranging from 7 days to 90 years. A specially modified laryngoscope with multiple ports into which a 14‐ or 16‐gauge ventilation needle can be advanced just distal to the vocal cords simplifies this form of anesthesia and ventilation.
Image navigation as a means to expand the boundaries of fluorescence-guided surgery

Hybrid tracers that are both radioactive and fluorescent help extend the use of fluorescence-guided surgery to deeper structures. Such hybrid tracers facilitate preoperative surgical planning using (3D) scintigraphic images and enable synchronous intraoperative radio- and fluorescence guidance. Nevertheless, we previously found that improved orientation during laparoscopic surgery remains desirable. Here we illustrate how intraoperative navigation based on optical tracking of a fluorescence endoscope may help further improve the accuracy of hybrid surgical guidance. After feeding SPECT/CT images with an optical fiducial as a reference target to the navigation system, optical tracking could be used to position the tip of the fluorescence endoscope relative to the preoperative 3D imaging data. This hybrid navigation approach allowed us to accurately identify marker seeds in a phantom setup. The multispectral nature of the fluorescence endoscope enabled stepwise visualization of the two clinically approved fluorescent dyes, fluorescein and indocyanine green. In addition, the approach was used to navigate toward the prostate in a patient undergoing robot-assisted prostatectomy. Navigation of the tracked fluorescence endoscope toward the target identified on SPECT/CT resulted in real-time gradual visualization of the fluorescent signal in the prostate, thus providing an intraoperative confirmation of the navigation accuracy.
Understanding X.500 - the directory

From the Publisher: Understanding X.500 The Directory describes, in lay terms, the contents of both the 1988 and 1993 editions of the ISO OSI Directory Standard (CCITT Recommendation X.500). An in-depth account is given of all the features of the Standard and numerous examples of its application are provided throughout. The implications of the Standard are related to implementation details in terms of product usefulness, differentiation and ease of management. Key features of the text are that it is fully up-to-date with all the features of the 1993 edition of the X.500 Standard; it describes clearly all X.500 terminology such as DSA, DUA, DIT; it explains X.500 security features such as asymmetric encryption and access controls; and it describes the use of X.500 by other applications such as EDI and X.400.