Miracle-dz/UniFAR-FTUs huggingface dataset:
Wave functions and two-electron probability distributions of the Hooke's-law atom and helium

The Hooke's-law atom (hookium) provides an exactly soluble model for a two-electron atom in which the nuclear-electron Coulombic attraction has been replaced by a harmonic one. Starting from the known exact position-space wave function for the ground state of hookium, we present the momentum-space wave function. We also look at the intracules, two-electron probability distributions, for hookium in position, momentum, and phase space. These are compared with the Hartree-Fock results and the Coulomb holes (the difference between the exact and Hartree-Fock intracules) in position, momentum, and phase space are examined. We then compare these results with analogous results for the ground state of helium using a simple, explicitly correlated wave function.
Direct adaptive NN control of a class of nonlinear systems

In this paper, direct adaptive neural-network (NN) control is presented for a class of affine nonlinear systems in the strict-feedback form with unknown nonlinearities. By utilizing a special property of the affine term, the developed scheme,avoids the controller singularity problem completely. All the signals in the closed loop are guaranteed to be semiglobally uniformly ultimately bounded and the output of the system is proven to converge to a small neighborhood of the desired trajectory. The control performance of the closed-loop system is guaranteed by suitably choosing the design parameters. Simulation results are presented to show the effectiveness of the approach.
Stem cell factor stimulates chicken osteoclast activity in vitro

Stem cell factor (SCF) is a polypeptide growth factor active on multiple cell types, mainly of hematopoietic origin. We studied the effects of avian SCF on the differentiation of chicken osteoclasts from their putative progenitors as well as on the bone‐resorbing activity of terminally differentiated osteoclasts. Osteoclast formation was analyzed in long‐term cocultures of osteoblasts and nonadherent, osteoclast‐depleted bone marrow cells. Osteoclast activity was studied in short‐term (48 h) cultures of bone marrow cell populations enriched for osteoclasts, on dentine slices. SCF strongly enhanced osteoclast differentiation. The IL‐6‐related chicken myelomonocytic growth factor (cMGF) had a similar effect, and the effects of SCF and cMGF were additive. SCF, but not cMGF, also stimulated the bone‐resorbing activity of existing osteoclasts. As osteoblasts have been found to regulate osteoclast activity and formation, chicken osteoblasts were tested for their ability to express and secrete SCF. Reverse transcriptase‐polymerase chain reaction (RT‐PCR) analysis showed that osteoblasts express SCF mRNA and that parathyroid hormone increases expression levels about fourfold. SCF did not accumulate in the culture medium, but remained cell (osteoblasts) surface associated. —van't Hof, R. J., von Lindern, M. , Nijweide, P. J., Beug, H. Stem cell factor stimulates chicken osteoclast activity in vitro. FASEB J. 11, 287‐293 (1997)
Global Inhibition of Lef1/Tcf-dependent Wnt Signaling at Its Nuclear End Point Abrogates Development in Transgenic Xenopus Embryos*

Analysis of canonical Wnt signaling during vertebrate development by means of knock-out or transgenic approaches is often hampered by functional redundancy as well as pathway bifurcations downstream of the manipulated components. We report the design of an optimized chimera capable of blocking transcriptional activation of Lef1/Tcf-β-catenin target genes, thus enabling intervention with the canonical Wnt pathway at its nuclear end point. This construct was made hormone-inducible, both functionally and transcriptionally, and was transgenically integrated in Xenopus embryos. Down-regulation of target genes was clearly observed upon treatment of these embryos with dexamethasone. In addition, exposure of variously aged transgenic embryos to dexamethasone caused complex phenotypes with many new but also several recognizable features stemming from inhibition of canonical Wnt signaling. At least in some tissues, a significant reduction in cell proliferation and an increase in programmed cell death appeared to underlie these phenotypes. Our inducible transgenic system can serve a broad range of experimental settings designed to unveil new functional aspects of Lef1/Tcf-β-catenin signaling during vertebrate embryogenesis.
Improved technique for automated classification of protein Subcellular Location patterns in fluorescence microscope images

The genomic revolution promises a complete understanding of the mechanisms by which cells and tissues carry out their functions. As proteins are integral components of cell function, it is critical to understand their properties such as structure and localization. Knowledge of a protein's subcellular distribution can contribute to a complete understanding of its function. Processing of subcellular image sets is still mostly manual and it causes the process inefficient and error-prone. But in recent years, try to perform high-resolution; high-throughput analysis for ten thousands of expressed proteins in the many cell types and cellular conditions under which they may be found creates. In this review, we describe a systematic approach for interpreting protein subcellular distributions using modified threshold adjacency statistics (MTAS) set of Subcellular Location Features (SLF). Previous work that uses threshold adjacency statistics (TAS), introduces a set of Subcellular Location Features which are computed by counting the number of threshold pixels adjacent. But here a novel method has been used that determines a modified features set, to improve the recognition of protein subcellular location patterns in 2D fluorescence microscope images with high accuracy and high speed.
Clinical Significance of First-Trimester Screening of the Retronasal Triangle for Identification of Primary Cleft Palate

Objective: To investigate the use of the retronasal triangle (RNT) for identification of orofacial cleft (OC) in the first trimester and the clinical application of three-dimensional (3D) ultrasound techniques for confirming the diagnosis of OC. Methods: A total of 5,054 women with singleton pregnancies underwent first-trimester screening for Down syndrome at 11-13+6 weeks. The RNT was scanned in each fetus, and 3D volumetric images of cases with abnormal or indeterminate RNT were obtained. Results: Satisfactory images were obtained from all cases. Seven cases (1.4‰) of abnormal RNT were diagnosed as OC in the first trimester, which were confirmed at a 16 weeks scan or at a postmortem examination. One case that was considered a normal RNT was diagnosed with OC at 22+2 weeks and after term delivery. Six cases of indeterminate RNT were diagnosed as normal by 3D ultrasound. Identification of OC by visualization of the RNT in the first trimester had a sensitivity of 87.5% and a specificity of 99.9%. Conclusion: The RNT is an important sonographic landmark that has a high sensitivity and specificity for the detection of OC in the first trimester. 3D ultrasound is an important tool that aids in confirming diagnosis of OC in the first and second trimesters.
Genetic admixture and asthma‐related phenotypes in Mexican American and Puerto Rican asthmatics

Genetic association studies in admixed populations may be biased if individual ancestry varies within the population and the phenotype of interest is associated with ancestry. However, recently admixed populations also offer potential benefits in association studies since markers informative for ancestry may be in linkage disequilibrium across large distances. In particular, the enhanced LD in admixed populations may be used to identify alleles that underlie a genetically determined difference in a phenotype between two ancestral populations. Asthma is known to have different prevalence and severity among ancestrally distinct populations. We investigated several asthma‐related phenotypes in two ancestrally admixed populations: Mexican Americans and Puerto Ricans. We used ancestry informative markers to estimate the individual ancestry of 181 Mexican American asthmatics and 181 Puerto Rican asthmatics and tested whether individual ancestry is associated with any of these phenotypes independently of known environmental factors. We found an association between higher European ancestry and more severe asthma as measured by both forced expiratory volume at 1 second (r=−0.21, p=0.005) and by a clinical assessment of severity among Mexican Americans (OR: 1.55; 95% CI 1.25 to 1.93). We found no significant associations between ancestry and severity or drug responsiveness among Puerto Ricans. These results suggest that asthma severity may be influenced by genetic factors differentiating Europeans and Native Americans in Mexican Americans, although differing results for Puerto Ricans require further investigation. Genet. Epidemiol. 2005. © 2005 Wiley‐Liss, Inc.
SOFTWARE DEFINED RADIO CONCEPT IN DIFFERENT SYSTEMS

Nowadays we are facing a continuous development of different technical systems using the frequency spectrum. People have more and more devices in their hands, the same ones used by the Defence Forces, as well. While developing them experts have to take into consideration not only the use of advanced technology, but also the ability to offer their products at low cost. In connection with the systems that are dependent on the frequency spectrum, the Software Defined Radio (SDR) concept offers a suitable solution. Napjainkban a frekvenciaspektrumot használó különböző technikai eszközök folyamatos fejlődésének vagyunk tanúi. Az embereknek egyre több és több eszköz van a kezükben és természetesen a rendvédelmi erők is alkalmazzák azokat. Ezen eszközök fejlesztése során a fejlesztőknek nemcsak a fejlett technológiát kell figyelembe venni, de az alacsony költségszintet is. Ezen, a frekvenciatartomány alkalmazhatóságától függő eszközökkel kapcsolatban a szoftverrádiós koncepció megfelelő megoldást nyújt.
Learning Gene Network Using Time-delayed Bayesian Network

Exact determination of a gene network is required to discover the higher-order structures of an organism and to interpret its behavior. Most research work in learning gene networks either assumes that there is no time delay in gene expression or that there is a constant time delay. This paper shows how Bayesian Networks can be applied to represent multi-time delay relationships as well as directed loops. The intractability of the network learning algorithm is handled by using an improved mutual information criterion. Also, a new structure learning algorithm, "Learning By Modification", is proposed to learn the sparse structure of a gene network. The experimental results on synthetic data and real data show that our method is more accurate in determining the gene structure as compared to the traditional methods. Even transcriptional loops spanning over the whole cell can be detected by our algorithm.
Productivity in Soviet Agriculture

The slowdown of growth in the Soviet economy has renewed interest in the agricultural productivity of the Soviet Union. The failure of agriculture to grow at the pace of industry has hampered overall expansion, and domestic crop failure has induced grain purchases abroad. The bottlenecks to Soviet agricultural growth and development are diverse. On the one hand, they may be inevitable, for the resource endowment of the Soviet Union, where the range of temperature is great and the level of precipitation is unpredictable, does not favor agriculture. On the other hand, they may be systemic, for Soviet agriculture has been criticized for weak labor incentives, stifling bureaucratic controls, and overly large farms.
DFT model errors for finite length observations with spatially distributed sensors

The use of sensor systems, with multiple, spatially separated receivers, is ever growing. it is assumed that the propagation delays, from transmitter to receivers, are translated to phase expressions in the frequency domain. We investigate this property and demonstrate the addition of an edge effect. We use signal-to-interference ratio (SIR) notation to quantify this effect and analyze its influence. We demonstrate our work by estimating the influence of the edge effect on localization accuracy of direct position determination (DPD) method using small error analysis, compared with Monte-Carlo simulations. To conclude our work we discuss some ways of mitigating the error hereby introduced.
Bioinspired Tracking Control of High Speed Nonholonomic Ground Vehicles

The behavior of nature's predators is considered for designing a high speed tracking controller for nonholonomic vehicles, whose dynamics are represented using a unicycle model. To ensure that the vehicle behaves intuitively and mimics the biologically inspired predator-prey interaction, saturation constraints based on Ackermann steering kinematics are added. A new strategy for mapping commands back into a viable envelope is introduced, and the restrictions are accounted for using Lyapunov stability criteria. Following verification of the saturation constraints, the proposed algorithm was implemented on a testing platform. Stable trajectories of up to 9m/s were achieved. The results presented show that the algorithm demonstrates significant promise in high speed trajectory tracking with obstacle avoidance.
Nonlinear subsidence rate estimation using permanent scatterers in differential SAR interferometry

Discrete and temporarily stable natural reflectors or permanent scatterers (PS) can be identified from long temporal series of interferometric SAR images even with baselines larger than the so-called critical baseline. This subset of image pixels can be exploited successfully for high accuracy differential measurements. We discuss the use of PS in urban areas, like Pomona, CA, showing subsidence and absidence effects. A new approach to the estimation of the atmospheric phase contributions, and the local displacement field is proposed based on simple statistical assumptions. New solutions are presented in order to cope with nonlinear motion of the targets.
Expression of the heat-modifiable major outer membrane protein of Haemophilus influenzae type b is unrelated to virulence

The heat-modifiable major outer membrane protein (P1) of Haemophilus influenzae type b (Hib) has been shown to be both exposed on the cell surface and capable of inducing the synthesis of antibodies protective against experimental Hib disease. Chemical mutagenesis of a recombinant plasmid containing the Hib gene encoding P1 resulted in inactivation of P1 expression by this plasmid. The mutated P1 gene was transformed into Hib to obtain an isogenic mutant lacking only the ability to synthesize this surface protein. In addition, the P1 gene was inserted into a plasmid shuttle vector and used to construct a recombinant Hib strain that overexpressed the P1 protein. Lack of P1 expression did not affect the ability of Hib to grow in vitro. Neither the absence nor the overproduction of P1 affected expression of capsular polysaccharide and lipooligosaccharide by Hib. The P1-negative mutant and the P1-overexpressing strain were both as susceptible to the bactericidal activity of pooled normal human serum as was the wild-type parent strain, while the P1-negative mutant was as resistant to the bactericidal activity of normal infant rat serum as was the wild-type parent strain. The P1-negative mutant was no less virulent than was the wild-type parent strain in an animal model system, such that both the numbers of animals infected by this mutant and the mean magnitudes of the resultant bacteremias were essentially identical to those obtained with challenge by the wild-type parent strain. Similarly, overexpression of P1 did not detectably affect the virulence of Hib. These data indicate that this protective protein antigen plays no detectable role in the expression of virulence by Hib, as assessed in an animal model system.
Evidence for an expression of blood group A antigen on platelet glycoproteins IV and V

Summary. Blood group ABO antigens are known to be carried by several platelet glycoproteins (GP), e. g. GPIb, GPIIa, GPIIb, GPIIIa and PECAM. Beside these proteins, we recently observed that blood group A antigen was also expressed on some other uncharacterized platelet proteins (70–90 kDa) having electrophoretic mobilities closely resembling those of GPIV and GPV. These findings prompted us further to characterize these latter ABO‐expressing platelet proteins. By antigen capture ELISA, wherein the monoclonal antibodies (mAbs) CLB‐IVC7 and CLB‐SW16 were used to hold the corresponding antigens GPIV and GPV, human anti‐A specifically bound to these proteins derived from A1‐platelets; neither GPIV nor GPV derived from A2‐, B‐ or O‐platelets bound anti‐A. In a Western blot assay using immunoprecipitated GPIV and GPV as antigens, mAb anti‐A immunostained GPIV and GPV precipitated from A1, but not from A2 and O platelets. These results conclusively demonstrate that blood group A antigen is expressed on platelet GPIV and GPV.
Online location data : Analysis of publicly available trajectory data sources

With the availability of consumer GPS devices the amount of online location data publicly accessible are growing fast. Creating annotated photos or other resources with single location data is very common today. Moreover sharing of moving history data in the form of GPS tracks is becoming popular now. In this paper we analyze three leading services which provide GPS tracks for uploading, downloading and sharing. Besides comparing the growth of these services with other location databases like Flickr our results show that the data fits the requirements needed for doing location data recommendation.
Surgical Staging in Endometrial Cancer: Clinical—Pathologic Findings of a Prospective Study

The pathologic features of a prospective study of FIGO stage I endometrial cancer is presented. The uterus, tubes, ovaries, and pelvic lymph nodes of 222 cases and aortic nodes of 157 cases have been analyzed. The surgical–pathologic specimen would suggest a negligible risk for lymph node metastasis if: cancer is confined to the endometrium irrespective of grade, invasion is superficial for grades 1 and 2 tumor, the intermediate third of the myometrium is invaded for grade 1 tumor only, and occult disease is not present in the cervix and/or adnexa. Conversely, a substantial risk for lymph node metastasis exists if the surgical-pathologic study identifies superficial myometrial invasion by grade 3 cancer, intermediate myometrial invasion by grade 2 or 3 cancer, deep myometrial invasion by cancer of any grade, vascular space involvement, and extension of tumor to the cervix and/or adnexa.
GOFCOX : a computer program for the goodness-offit analysis of the Cox proportional hazards model

GOFCOX is a user-friendly FORTRAN program for assessing the adequacy of the Cox proportional hazards model. The underlying methodology is based on the comparison of the maximum partial likelihood estimator and a weighted parameter estimator. The latter is the root to an estimation equation that assigns varying weights to the individual contributions to the partial likelihood score function. The weighted and unweighted parameter estimators have the same expectation under the Cox model, but tend to differ when the model is inappropriate. The GOFCOX program computes a rich class of weighted parameter estimators and corresponding goodness-of-fit test statistics. The program runs on both mainframe computers and microcomputers. The running time is minimal even for large data sets. A simple example is provided to illustrate the features of the program.
Improving the bar-coded medication administration system at the Department of Veterans Affairs.

Medication errors account for significant patient morbidity and mortality[1][1]–[3][2] as well as legal, operational, and patient care costs. [4][3],[5][4] Common causes of these errors, such as lack of knowledge about a drug, lack of information about a patient, rule violations, and transcription
Duration of patency of laser-assisted tympanic membrane fenestration.

BACKGROUND Laser-assisted tympanic membrane fenestration (LTMF) provides intermediate-duration middle ear ventilation, which benefits selected children with acute otitis media (AOM) and otitis media with effusion (OME). OBJECTIVE To evaluate clinical and technical factors that may affect duration of LTMF patency. DESIGN Prospective clinical cohort effectiveness trial. SETTING Four tertiary care children's hospitals. PATIENTS Volunteer sample of 251 children (430 ears) followed up at 1, 2, 3, 4, 8, and 12 weeks; time to fenestration closure was evaluable in 201 ears, and assessment of cure at study conclusion was evaluable in 128 ears. INTERVENTIONS Laser-assisted tympanic membrane fenestration for prospectively defined AOM or OME. The surgeon determined spot size, wattage, and concurrent adenoidectomy based on clinical judgment. MAIN OUTCOME MEASURES Cure of AOM/OME with effusion at 90 days and duration of LTMF patency relative to spot size (1.8-2.8 mm), fenestration location on tympanic membrane, power (7-22 W), concurrent adenoidectomy, age, diagnosis (AOM vs OME), type of effusion, and preoperative tympanogram characteristics. Results are based on the number of ears that could be evaluated at each data collection interval. RESULTS Fenestrations remained patent for 2 to 4 weeks (mean = 2.52, median = 2.0, SD = 1.4, n = 201); 97.4% were closed at 6-week follow-up. Spot sizes of 2.4 and 2.6 mm had a higher rate of patency than 2.0-mm spot size at 3 weeks following LTMF. Cure at 90 days was related to duration of patency for all patients combined and for patients treated for AOM and OME, but not for those undergoing adjunctive adenoidectomy. Cure at 90 days was related to larger spot size for all patients combined and those treated for AOM. Other investigated factors did not achieve statistical significance. CONCLUSIONS Spot size of 2.4 mm or greater results in improved duration of LTMF patency, persisting for up to 3 weeks after LTMF, especially for treatment of AOM. Increased duration of LTMF patency correlates with greater incidence of cure of middle ear effusion at 90 days. Additional investigation is indicated to determine optimum spot size and optimum duration of patency for disease- severity-adjusted populations.
Comparison of CCTT-core split-winding integrated magnetic and discrete inductors for high-power DC-DC converters

This paper presents a comparison of two magnetic component topologies for use in high-power high-current dc-dc boost converters. A 97.2 kW three-phase dc-dc converter prototype is considered as the baseline design. The split-winding integrated magnetic (CCTT IM) and two-phase discrete inductor (2L) topologies are then designed to have the same worst-case phase-current ripple condition for a 72 kW prototype. The magnetic components are optimized for varying number of turns in order to achieve the minimum boxed volume. Magnetic and semiconductor power loss are investigated. High-power experimental results are presented for the baseline 3L (97.2 kW) and CCTT IM (72 kW) converters. 3.8 kW experimental results are presented which compares and validates the 2L and CCTT IM concepts under like-for-like operating conditions.
CLF Based Stabilization of Chaos in PMSM with Uncertain Parameters

The robust stabilization problem of chaos suppression for permanent magnet synchronous motors (PMSM) drive system is investigated in presence of parametric uncertainties. Based on control Lyapunov function (CLF) approach, a new state feedback controller is designed to realize the state of the system globally asymptotically stable. The stability of the proposed control scheme is verified via Lyapunov stable theory. Finally, simulation results illustrate the effectiveness of the presented method. DOI : http://dx.doi. org/10.11591/telkomnika.v12i4. 4096