Miracle-dz/UniFAR-FTUs huggingface dataset:
Sinus Histiocytosis Clinically Limited to the Skin

Abstract: Sinus histiocytosis with massive lymphadenopathy is a rare clinicopalhologic entity thai affects mainly children and young adults. Although the lymph nodes are the most common sites of involvement, extranodal infiltrates may arise in the orbits, skin, upper respiratory tract, and bone, as well as other organs. Approximately 10% of patients have had cutaneous infiltrates, but very few of them have had lesions limited to the skin. We treated a 15‐year‐old female with cutaneous nodules as the sole manifestation of the disease.
Analgetic Contribution of Sufentanil during Halothane Anesthesia: A Mechanism Involving Serotonin

Catecholamine and serotonin concentrations in the cord, medulla, and hypothalamus were measured in rats after saline, after sufentanil sufficient to reduce the minimum alveolar concentration (MAC) of halothane by 30% or less, or after sufentanil sufficient to reduce the MAC of halothane by 80% or more. In the cord, high doses of sufentanil resulted in a 13.4% reduction (P < 0.05) in serotonin concentration compared to saline control and a 17.4% reduction (P < 0.05) in serotonin concentration compared to low dosages of sufentanil. A 12.8% reduction (P < 0.05) in medullary serotonin also was observed with high sufentanil compared to low sufentanil. Epinephrine decreased significantly in the hypothalamus at the high sufentanil dose. No other significant differences were found in catecholamine content. The experimental results support the hypothesis that sufentanit may contribute to an analgetic component of general anesthesia by modulating nociception via the release of 5-HT.
Acute Effects of Resistance Exercise With Continuous and Intermittent Blood Flow Restriction on Hemodynamic Measurements and Perceived Exertion

This study compared the acute effects of low-intensity resistance exercise (RE) sessions for the upper limb with continuous and intermittent blood flow restriction (BFR) and high-intensity RE with no BFR on lactate, heart rate, double product (DP; heart rate times systolic blood pressure), and perceived exertion (RPE). Ten recreationally trained men (1–5 years strength training; age mean = 19 ± 0.82 years) performed three experimental protocols in random order: (a) low-intensity RE at 20% one-repetition maximum (1RM) with intermittent BFR (LI + IBFR), (b) low-intensity RE at 20% 1RM with continuous BFR (LI + CBFR), and (c) high-intensity RE at 80% 1RM. The three RE protocols increased lactate and DP at the end of the session (p < .05) and increased heart rate at the end of each exercise (p < .05). However, greater local and general RPE was observed in the high-intensity protocol compared with LI + IBFR and LI + CBFR in the lat pull-down, triceps curl, and biceps curl exercises (p < .05). A greater percentage change in DP and lactate was observed for continuous BFR compared with intermittent BFR; however, RPE was lower for intermittent BFR. In conclusion, intermittent BFR appears to be an excellent option for physical training because it did not differ significantly from continuous BFR in any variable and promoted a lower percentage change in DP and RPE.
Channels formed by subnanomolar concentrations of the toxin aerolysin trigger apoptosis of T lymphomas

Aerolysin is a channel‐forming toxin that binds to glycosylphosphatidylinositol (GPI)‐anchored proteins, such as Thy‐1, on target cells. Here, we show that subnanomolar concentrations of aerolysin trigger apoptosis of T lymphomas. Using inactive aerolysin variants, we determined that apoptosis was not directly triggered by binding to GPI‐anchored receptors, nor was it caused by receptor clustering induced by toxin oligomerization. Apoptosis was caused by the production of a small number of channels in the cell membrane. Channel formation resulted in a rapid increase in intracellular calcium, which may have been the signal for apoptosis. Overexpression of the antiapoptotic protein bcl‐2 blocked aerolysin‐induced apoptosis, although this effect was overcome at higher toxin concentrations.
Targeting G-protein coupled receptor-related signaling pathway in a murine xenograft model of appendiceal pseudomyxoma peritonei

Cancer cells aberrantly express mucins to enhance their survival. Relative chemoresistance of appendiceal pseudomyxoma peritonei (PMP) is attributed to abundant extracellular mucin 2 (MUC2) protein production. We hypothesized that simultaneous MUC2 inhibition and apoptosis induction would be effective against mucinous tumors. In vitro studies were conducted using LS174T cells (MUC2-secreting human colorectal cancer cells), PMP explant tissue, and epithelial organoid cultures (colonoids) derived from mucinous appendix cancers. In vivo studies were conducted using murine intraperitoneal patient-derived xenograft model of PMP. We found COX-2 over-expression in PMP explant tissue, which is known to activate G-protein coupled EP4/cAMP/PKA/CREB signaling pathway. MUC2 expression was reduced in vitro by small molecule inhibitors targeting EP4/PKA/CREB molecules and celecoxib (COX-2 inhibitor), and this was mediated by reduced CREB transcription factor binding to the MUC2 promoter. While celecoxib (5–40 µM) reduced MUC2 expression in vitro in a dose-dependent fashion, only high-dose celecoxib (≥ 20 µM) decreased cell viability and induced apoptosis. Chronic oral administration of celecoxib decreased mucinous tumor growth in our in vivo PMP model via a combination of MUC2 inhibition and induction of apoptosis. We provide a preclinical rationale for using drugs that simultaneously inhibit MUC2 production and induce apoptosis to treat patients with PMP.
Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Menstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case‐control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case‐control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Of all factors analyzed, only younger age at menarche (<12 vs. 13 years) was moderately associated with an increased risk of pancreatic cancer in the full cohort; however, this result was marginally significant (HR = 1.44; 95% CI = 0.99–2.10). CYP17A1 rs619824 was associated with HRT use (p value = 0.037) in control women; however, none of the SNPs alone, in combination, or as haplotypes were associated with pancreatic cancer risk. In conclusion, with the possible exception of an early age of menarche, none of the menstrual and reproductive factors, and none of the 12 common genetic variants we evaluated at the CYP17A1 locus makes a substantial contribution to pancreatic cancer susceptibility in the EPIC cohort.
Increased hippocampal, thalamus and amygdala volume in long‐term lithium‐treated bipolar I disorder patients compared with unmedicated patients and healthy subjects

Magnetic resonance imaging (MRI) studies in bipolar I disorder (BD‐I) suggest that lithium is associated with increased volumes of cortico‐limbic structures. However, more rigorous control of confounding factors is needed to obtain further support for this hypothesis. The aim of the present study was to assess differences in brain volumes among long‐term lithium‐treated BD‐I patients, unmedicated BD‐I patients, and healthy controls.
Learning Logic Rules for the Tower of Knowledge Using Markov Logic Networks

In this paper, we propose a novel logic-rule learning approach for the Tower of Knowledge (ToK) architecture, based on Markov logic networks, for scene interpretation. This approach is in the spirit of the recently proposed Markov logic networks for machine learning. Its purpose is to learn the soft-constraint logic rules for labeling the components of a scene. In our approach, FOIL (First Order Inductive Learner) is applied to learn the logic rules for MLN and then gradient ascent search is utilized to compute weights attached to each rule for softening the rules. This approach also benefits from the architecture of ToK, in reasoning whether a component in a scene has the right characteristics in order to fulfil the functions a label implies, from the logic point of view. One significant advantage of the proposed approach, rather than the previous versions of ToK, is its automatic logic learning capability such that the manual insertion of logic rules is not necessary. Experiments of labeling the identified components in buildings, for building scene interpretation, illustrate the promise of this approach.
MADM method considering attribute aspirations with an application to selection of wastewater treatment technologies

Purpose – The purpose of this paper is to develop a method for solving the multiple attribute decision-making (MADM) problem in which the decision maker can provide the five types of attribute aspirations, namely: benefit type with requirements; cost type with requirements; interval type; benefit type; and cost type. Design/methodology/approach – First, for each type of attribute aspiration, the calculation formula of utility values of alternative concerning attributes is given. Then, using the calculation formulae, the attribute values are transformed into the corresponding utility values. On the basis of this, the overall ranking value of each alternative is calculated. Further, a ranking order of alternatives can be determined according to the obtained overall ranking values. Findings – Research shows that it is necessary to develop the method for MADM with attribute aspirations. The example shows that the proposed method is applicable. Practical implications – The proposed method can be applied to the.
Validity and reliability of a novel measure of activity performance and participation

Abstract Purpose: To develop and evaluate an innovative clinician-rated measure, which produces global numerical ratings of activity performance and participation. Method: Repeated measures study with 48 community-dwelling participants investigating clinical sensibility, comprehensiveness, practicality, inter-rater reliability, responsiveness, sensitivity and concurrent validity with Barthel Index. Results: Important clinimetric characteristics including comprehensiveness and ease of use were rated >8/10 by clinicians. Inter-rater reliability was excellent on the summary scores (intraclass correlation of 0.95–0.98). There was good evidence that the new outcome measure distinguished between known high and low functional scoring groups, including both responsiveness to change and sensitivity at the same time point in numerous tests. Concurrent validity with the Barthel Index was fair to high (Spearman Rank Order Correlation 0.32–0.85, p > 0.05). The new measure’s summary scores were nearly twice as responsive to change compared with the Barthel Index. Other more detailed data could also be generated by the new measure. Conclusions: The Activity Performance Measure is an innovative outcome instrument that showed good clinimetric qualities in this initial study. Some of the results were strong, given the sample size, and further trial and evaluation is appropriate. Implications for Rehabilitation The Activity Performance Measure is an innovative outcome measure covering activity performance and participation. In an initial evaluation, it showed good clinimetric qualities including responsiveness to change, sensitivity, practicality, clinical sensibility, item coverage, inter-rater reliability and concurrent validity with the Barthel Index. Further trial and evaluation is appropriate.
Involvement of integrin alpha V gene expression in human melanoma tumorigenicity.

Human melanoma originates in the skin and can lead to wide-spread metastatic disease. Analysis of melanoma biopsy material has shown that the vitronectin receptor, integrin alpha v beta 3, is a specific marker of the most malignant cells, i.e., vertically invasive primary lesions or distant metastases (Albelda, S. M., S. A. Mette, D. E. Elder, R. Stewart, L. Damjanovich, M. Herlyn, and C. A. Buck. 1990. Cancer Res. 50:6757-6764), suggesting a role for this adhesion receptor in the malignant growth of human melanoma tumors. A cell model was established to analyze the role of alpha v integrins on the tumorigenicity of human melanoma. From M21 human melanoma cells, stable variants were selected that lack alpha v gene expression and thus fail to express integrin alpha v beta 3 (M21-L cells). These cells not only lost the ability to attach to vitronectin but showed a dramatic reduction in tumorigenicity when transplanted into athymic nude mice, compared with M21 cells, even though both cell types showed identical beta 1 integrin expression and growth properties in vitro. M21-L cells were stably transfected with a cDNA-encoding alpha v. This resulted in the functional expression of integrin alpha v beta 3 on these cells and completely restored their tumorigenicity. Thus, integrin alpha v gene expression and the resulting adhesive phenotype are directly involved in the proliferation of human melanoma in vivo.
Experiences with steady-state PMU compliance testing using standard relay testing equipment

This paper presents the results of steady state compliance testing of phasor measurement units (PMUs) from three different vendors in a laboratory environment. Testing is performed by providing three phase voltage and current injections to the VT and CT inputs of the PMUs through Freja-300 stand-alone protection relay test set. Testing is performed according to the standard “IEEE C37.242-2013 - IEEE Guide for Synchronization, Calibration, Testing, and Installation of Phasor Measurement Units (PMUs) for Power System Protection and Control”. The paper discusses the test setup, testing process and overall test results of this project. The limitations of stand-alone testing equipment and recommendations for utilizing real-time hardware-in-the-loop simulation for thorough testing of PMUs are also presented.
Multi-sensor Gait Analysis for Gender Recognition

: Gender recognition has been adopted recently by researchers due to its beneﬁts in many applications such as recommendation systems and health care. The rise of using smart phones in everyday life made it very easy to have sensors like accelerometer and gyroscope in phones and other wearable devices. Here, we propose a robust method for gender recognition based on data from Inertial Measurement Unit (IMU) sensors. We explore the use of wavelet transform to extract features from the accelerometer and gyroscope signals along side with proper classiﬁers. Furthermore, we introduce our own collected dataset (EJUST-GINR-1) which contains samples from smart watches and IMU sensors placed at eight different parts of the human body. We investigate which sensor placements on the body best distinguish between males and females during the activity of walking. The results prove that wavelet transform can be used as a reliable feature extractor for gender recognition with high accuracy and less computations than other methods. In addition, sensors placed on the legs and waist perform better in recognizing the gender during walking than other sensors.
Critical Review: Are Simultaneous Bilateral Cochlear Implants More Effective in Promoting Normal Functioning Bilateral Auditory Pathways in Children than Sequential Bilateral Cochlear Implants?

This critical review examines the use of the P1 from cortical evoked auditory potential responses to determine whether children fitted with simultaneous bilateral cochlear implants will develop more efficient or normalized bilateral pathways in their central auditory system than children fitted with sequential bilateral implants. Study designs included: mixed (repeated measures) cohort study (2) and case studies (3). Overall, the research suggests that children fitted early in life with bilateral cochlear implants either simultaneously or sequentially after a short interimplant delay will more likely develop normalized bilateral pathways. This is clinically relevant to parents and audiologists in deciding whether there is a significant benefit to providing a child with implants simultaneously versus sequentially.
Integration of Current-Reused VCO and Frequency Tripler for 24-GHz Low-Power Phase-Locked Loop Applications

This brief presents the integration of an 8-GHz voltage-controlled oscillator (VCO) and a frequency tripler for 24-GHz local oscillator generation. By stacking the VCO and the tripler with a current-reused topology, the power consumption of this integration can be saved. The proposed circuit with a total chip area of 0.7 mm × 0.8 mm is implemented in a 0.18-μm CMOS process. As the tuning voltage increases from 0 to 2 V, the measured frequency tuning range (FTR) of the VCO is from 7.06 to 8.33 GHz. The final resulting output frequency from the tripler ranges from 21.18 to 24.98 GHz (16.5% FTR). The core circuit totally consumes 5 mA from a 1.8-V supply voltage. The measured phase noises at the VCO and frequency tripler outputs are -113.76 and -105.1 dBc/Hz at 1-MHz offset frequency, respectively, when Vtune is 0 V. The best evaluated figure of merit with tuning is -187.2 dBc/Hz. This integration of a VCO and a frequency tripler exhibits a high potential for the use in low-power 24-GHz phase-locked loops.
A maneuvering target detection in time-series Doppler spectrums with self-organizing model

This paper presents a probability of detection enhancement technique for a maneuvering target with a low radar cross section in time-series Doppler spectrums. The target signal and a noise variance are estimated by the self-organizing model applied to the particle filter and the history of the particle information is used for the detection with a constant false alarm rate. A Monte Carlo simulation is carried out for the performance investigation. The results show that the probability is enhanced, even when a target has a high angular velocity.
Improved selectivity and decreased spontaneous emission from an AR-HR coated SL-MQW DFB semiconductor laser amplifier

It is shown that the performance of a DFB filter/amplifier can be improved considerably with respect to selectivity and amplified spontaneous emission by applying a high reflective coating to the output facet. To illustrate this a strained-layer multiple quantum well DFB filter/amplifier with an output facet reflectivity of 97% is compared with a conventional, AR-coated phase adjusted DFB filter/amplifier. Peak fiber-to-fiber gains for these devices are 21 and 18 dB, respectively, when biased at 98% of their threshold current. The transmission gain of these DFB filter/amplifiers has been measured over a wavelength span of 30 nm. For the AR-HR coated SL-MQW DFB filter/amplifier the selectivity is improved with 11 dB resulting in an extinction ratio for interfering channels of better than 35 dB and the amplified spontaneous emission is reduced by 16 dB down to /spl minus/37 dBm compared to the conventional DFB filter/amplifier. <<ETX>>
Introduction: Bayesian Models and Markov Chain Monte Carlo Methods

The nine papers which follow all use snme form of Bayesian models and/or a Markov chain Monte Carlo (MCMC) implementation. Individual contributions within this group have a number of commonalities with other groups, particularly the "Haplotype Analysis" and the "Sequence Data and Population Structure" groups. Within this group of papers, there is also some substantial heterogeneity in approaches.
Analysis of dynamic changes in the proteome of a Bcl‐XL overexpressing Chinese hamster ovary cell culture during exponential and stationary phases

Mammalian cell cultures used for biopharmaceutical production undergo various dynamic biological changes over time, including the transition of cells from an exponential growth phase to a stationary phase during cell culture. To better understand the dynamic aspects of cell culture, a quantitative proteomics approach was used to identify dynamic trends in protein expression over the course of a Chinese hamster ovary (CHO) cell culture for the production of a recombinant monoclonal antibody and overexpressing the antiapoptotic gene Bcl‐xl. Samples were analyzed using a method incorporating iTRAQ labeling, two‐dimensional LC/MS, and linear regression calculations to identify significant dynamic trends in protein abundance. Using this approach, 59 proteins were identified with significant temporal changes in expression. Pathway analysis tools were used to identify a putative network of proteins associated with cell growth and apoptosis. Among the differentially expressed proteins were molecular chaperones and isomerases, such as GRP78 and PDI, and reported cell growth markers MCM2 and MCM5. In addition, two proteins with growth‐regulating properties, transglutaminase‐2 and clusterin, were identified. These proteins are associated with tumor proliferation and apoptosis and were observed to be expressed at relatively high levels during stationary phase, which was confirmed by western blotting. The proteomic methodology described here provides a dynamic view of protein expression throughout a CHO fed‐batch cell culture, which may be useful for further elucidating the biological processes driving mammalian cell culture performance. © 2012 American Institute of Chemical Engineers Biotechnol. Prog. , 2012
Variation Tolerant SRAM Cell for Low Power Applications

Static Random Access Memory (SRAM) is the important component across a wide range of microelectronics applications like high performance server processors, multimedia and System on Chip (SoC). The lower power consumption, static noise margin (SNM), read and write stability are the major design metrics for designing an SRAM cell. It is difficult to achieve that conventional 6 T SRAM cell in scaled technology, particularly in deep-subthreshold region. In this paper, impact of process parameters variations on various design metrics of the proposed cell are presented and compared with conventional 6T and 8T.The proposed 9T cell utilizes a scheme with separate read and write word lines it is shown that the 9T cell achieves improvements in power dissipation, performance and stability compared with previous designs (that require 6T and 8T) for low-power operation. The 9T scheme is amenable to small feature sizes as encountered in the deep sub-micron/nano ranges of CMOS technology. The proposed 9T SRAM cell designed in 130 nm Complementary Metal Oxide Semiconductor (CMOS) technology in the power supply voltage of 1.8 V. The simulation is done by using AARON 9.03 tool to achieve the power consumption of 91.55% lesser than existing method, Then the read and write delay of proposed 9T SRAM cell is reduced by 8.3% and 23.0% lesser than conventional 6T and 8T.
Highly Efficient $+$5-dB Parametric Gain Conversion Using Direct-Bonded PPZnLN Ridge Waveguide

We fabricated a 50-mm-long ZnO-doped quasi-phase-matched LiNbO ridge waveguide by employing the direct bonding and dry etching techniques. We obtained a second-harmonic generation conversion efficiency of 2400%/W and a second-harmonic output power of 148 mW with a pump power of 160 mW. We demonstrated 1.55-m-band wavelength conversion based on a cascade scheme. A parametric conversion gain of 5 dB was successfully achieved.