Miracle-dz/UniFAR-FTUs huggingface dataset:
Conceptualization and Measurement of the Spiritual and Psychological Dimensions of Wellness in a College Population

Abstract Wellness is commonly conceptualized as having many dimensions, but little effort has been made to evaluate how spiritual and psychological dimensions are related to overall wellness. To explore the relationship between measures of spiritual and psychological wellness and perceived wellness in a college student population, the authors administered a series of survey instruments to 112 undergraduate students under quiet classroom conditions. They used the Life Attitude Profile to measure spiritual wellness, the Life Orientation Test and the Sense of Coherence Scale to measure psychological wellness, and the Perceived Wellness Survey to measure overall wellness. Path analysis performed with a proposed theoretical model revealed that the effect of life purpose on perceived wellness was mediated by optimism and sense of coherence, which had independent effects on perceived wellness beyond that of life purpose. The findings suggested that an optimistic outlook and sense of coherence must be present for life purpose to enhance a sense of overall well-being.
A phase I study of a combination of anti‐CD19 and anti‐CD22 immunotoxins (Combotox) in adult patients with refractory B‐lineage acute lymphoblastic leukaemia

Novel agents are needed for patients with refractory and relapsed acute lymphoblastic leukaemia (ALL). Combotox is a 1:1 mixture of two immunotoxins (ITs), prepared by coupling deglycosylated ricin A chain (dgRTA) to monoclonal antibodies directed against CD22 (RFB4‐dgRTA) and CD19 (HD37‐dgRTA). Pre‐clinical data demonstrated that Combotox was effective in killing both pre‐B‐ALL cell lines and cells from patients with pre‐B ALL. A clinical study of paediatric patients in which 3 of 17 patients with ALL experienced complete remission, supported the preclinical work and motivated this study. This study was a Phase I, dose‐escalation trial using Combotox in adults with refractory or relapsed B‐lineage‐ALL. A cycle consisted of three doses, with one dose given every other day. Dose levels were 3, 5, 6, 7 and 8 mg/m2 per dose. Seventeen patients, aged 19–72 years, were enrolled in this multi‐institution study. The maximum tolerated dose was 7 mg/m2/dose (21 mg/m2/cycle) and vascular leak syndrome was the dose‐limiting toxicity. Two patients developed reversible grade 3 elevations in liver function tests. One patient achieved partial remission and proceeded to allogeneic stem cell transplantation. All patients with peripheral blasts experienced decreased blast counts following the administration of Combotox. Thus, Combotox can be safely administered to adults with refractory leukaemia.
Associating liver partition and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis: First case report in the literature

Alveolar echinococcosis (AE) is a zoonotic disease that is caused by Echinococcus multilocularis that affects liver and a variety of organs and tissues. It differs from other echinococcal disease because it shows tumor like behavior in the affected organ and tissues. The treatment of choice is concomitant medical therapy and resection with negative margins. Nevertheless, resection with the intent of negative margins (R0) may lead to serious complications such as liver failure. In the present case report, we used Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) procedure, which was defined in 2012 by Schnitzbauer et al, in a 28-year-old male patient to avoid complications of major liver resection in order to treat alveolar echinococcosis. Until now, we have not encountered any study using ALPPS procedure for the treatment of alveolar echinococcosis. In the present case report we aimed to show that ALPPS procedure can be safely performed for margin-negative resection of primary or recurrent AE that shows a tumor like behavior. It is our opinion that this procedure should be performed in centers that have expertise and sufficient technical capacity to perform liver transplantation and advanced liver surgery.
Factors in Social Perception: Seating Position

Ss made 8-point scale ratings of 5 target individuals photographed while seated at a rectangular table. Occupancy of the head position (rather than side locations) was consistent with higher ratings on all of the following scales: (1) Talkativeness, (2) Persuasiveness, (3) Leadership, (4) Self-confidence, (5) Friendliness, and (6) Intelligence. The occupant of the head position was also considered to “contribute most” to the group's performance. Sommer's (1967) hypothesis that status and/or dominance ascribes to an individual automatically as a function of the location he occupies was supported. Results were interpreted to demonstrate a “halo effect” reflecting cultural standards and traditions regarding the organization of social space. Some suggestions for future studies were presented.
Adapting to Workload Changes Through On-The-Fly Reconfiguration

High-end servers that can be partitioned into logical subsystems and repartitioned on the fly are now becoming available. This development raises the possibility of reconfiguring distributed systems online to optimize for dynamically changing workloads. This paper presents one approach to solving this online reconfiguration problem. In particular, we learn to identify, from only low-level system statistics, which of a set of possible configurations will lead to better performance under the current unknown workload. This approach requires no instrumentation of the system’s middleware or operating systems. We introduce an agent that is able to learn this model and use it to switch configurations online as the workload varies. Our agent is fully implemented and tested on a publicly available multi-machine, multi-process distributed system (the online transaction processing benchmark TPC-W). We demonstrate that our adaptive configuration is able to outperform any single fixed configuration in the set over a variety of workloads, including gradual changes and abrupt workload spikes.
A Novel Method of Anaerobic Performance Assessment in Swimming

Abstract Smolka, L and Ochmann, B. A novel method of anaerobic performance assessment in swimming. J Strength Cond Res 27(2): 533–539, 2013—The purpose of this study was to develop a novel, anaerobic efficiency test in swimming. The concept of this test was build upon the classic Wingate anaerobic test, with the difference that the dependent variables are extracted from an instantaneous speed curve. Twelve highly trained male swimmers, 19.3 (±3.3) years of age, 1.84 (±0.08) m in height, and 77 (±12.8) kg in weight, participated in the study. The swimmers swam a 100-m race in a 25-m pool, following the instructions to attain maximal swimming speed as quickly as possible and to keep maximal speed as long as possible. The race was recorded by means of video cameras (50 samples per second). Raw data were filtered by means of standard mathematical functions: smoothing and a polynomial function fit. The following speed parameters: maximal speed (Vmax), time to reach Vmax , time at Vmax , minimal speed (Vmin), and fatigue index were extracted from the filtered speed curve. Thorough assessment of anaerobic performance in swimming requires a swimming test leading to development of a speed curve obtained during a maximal effort race and not race time alone.
Affective problems in adults with mild learning disability: the roles of social disadvantage and ill health

Summary Mild learning disability is associated with an increased risk of affective disorder. This study examines the extent to which adult socio-economic disadvantage and ill health contribute to this risk. Samples were drawn from the 1958 National Child Development Study. Relative to a comparison group, mild learning disability at age 11 was associated with elevated rates of depressive symptoms throughout adult life, and carried a six-fold risk of chronic depressed mood. The group difference in depressed mood at age 43 years was in large part mediated by variations in adult socio-economic disadvantage and ill health.
Bracoviruses Contain a Large Multigene Family Coding for Protein Tyrosine Phosphatases

ABSTRACT The relationship between parasitic wasps and bracoviruses constitutes one of the few known mutualisms between viruses and eukaryotes. The virions produced in the wasp ovaries are injected into host lepidopteran larvae, where virus genes are expressed, allowing successful development of the parasite by inducing host immune suppression and developmental arrest. Bracovirus-bearing wasps have a common phylogenetic origin, and contemporary bracoviruses are hypothesized to have been inherited by chromosomal transmission from a virus that originally integrated into the genome of the common ancestor wasp living 73.7 ± 10 million years ago. However, so far no conserved genes have been described among different braconid wasp subfamilies. Here we show that a gene family is present in bracoviruses of different braconid wasp subfamilies (Cotesia congregata, Microgastrinae, and Toxoneuron nigriceps, Cardiochilinae) which likely corresponds to an ancient component of the bracovirus genome that might have been present in the ancestral virus. The genes encode proteins belonging to the protein tyrosine phosphatase family, known to play a key role in the control of signal transduction pathways. Bracovirus protein tyrosine phosphatase genes were shown to be expressed in different tissues of parasitized hosts, and two protein tyrosine phosphatases were produced with recombinant baculoviruses and tested for their biochemical activity. One protein tyrosine phosphatase is a functional phosphatase. These results strengthen the hypothesis that protein tyrosine phosphatases are involved in virally induced alterations of host physiology during parasitism.
System output combination for improved speaker diarization

System combination or fusion is a popular, successful and sometimes straightforward means of improving performance in many fields of statistical pattern classification, including speech and speaker recognition. Whilst there is significant work in the literature which aims to improve speaker diarization performance by combining multiple feature streams, there is little work which aims to combine the outputs of multiple systems. This paper reports our first attempts to combine the outputs of two state-of-the-art speaker diarization systems, namely ICSI’s bottom-up and LIA-EURECOM’s top-down systems. We show that a cluster matching procedure reliably identifies corresponding speaker clusters in the two system outputs and that, when they are used in a new realignment and resegmentation stage, the combination leads to relative improvements of 13% and 7% DER on independent development and evaluation sets. Index Terms: speaker diarization, system combination, fusion
Quantitative Selection Constants

The study of the genetics of human tumors produces numerical data concerning the frequencies of mutation of individual genes. These frequencies are dependent on a number of processes that act individually and differentially upon genes, and can in turn be conceptualized in quantitative terms to encompass the rates of random mutations within cells, the efficiencies of the evolution of initial mutations to produce the functional inactivation of genes, and selective pressures that act upon cellular populations. Some intuitive mathematical models can be used to organize and formalize our interpretation of the mutation rates of tumor-suppressor genes.
Combined caffeine and ephedrine ingestion improves run times of Canadian Forces Warrior Test.

The ingestion of a combination of caffeine (C) and ephedrine (E) has been reported to prolong exercise time to exhaustion during cycle ergometry at 85% VO2max. The present study was undertaken to investigate whether this enhancement would occur in a field setting and if drug ingestion on 1 d would affect performance 1 d later. Two hours after ingesting either a combination of 375 mg of C and 75 mg E (C+E), or a placebo (P), 9 healthy male recreational runners completed six balanced and double-blind trials of the Canadian Forces Warrior Test (WT), a 3.2 km run wearing "fighting order" which weighed about 11 kg. The trials were performed in sets of two runs, i.e., two runs were done 24 h apart, and these sets were separated by a minimum of 7 d. The sets were: C+E trial on day 1 (D1), placebo on day 2 (P2); placebo first (P1), C+E second (D2); and placebo first (P3), placebo second (P4). In addition, 1 wk before the treatment trials the subjects performed a control trial WT. During the WT, heart rates (HR) were recorded every minute. Plasma C and E levels immediately before the WT were similar for both C+E trials, but were undetectable for all P trials. Run times (mean+/-SD) were 15.3+/-0.6, 15.4+/-0.9, 15.5+/-1.2, 15.4+/-0.9, 15.4+/-0.9, 14.8+/-0.7, and 14.6+/-0.8 min for control, P1, P2, P3, P4, D1, D2 trials, respectively. The two C+E trial run times were similar and both were significantly faster (p < 0.05) than control and all placebo trials. HR during the WT was significantly higher (p < 0.05) for the C+E trials compared with the other trials. WT performance was not impaired by C+E ingestion 24 h earlier. In conclusion, performance of the WT was improved by ingestion of C+E.
Effects of Flexible Dry Electrode Design on Electrodermal Activity Stimulus Response Detection

Objective: The focus of this research is to evaluate the effects of design parameters including surface area, distance between and geometry of dry flexible electrodes on electrodermal activity (EDA) stimulus response detection. Methods: EDA is a result of the autonomic nervous system being stimulated, which causes sweat and changes the electrical characteristics of the skin. Standard silver/silver chloride (Ag/AgCl) EDA electrodes are rigid and lack conformability in contact with skin. In this study, flexible dry Ag/AgCl EDA electrodes were fabricated on a compliant substrate, used to monitor EDA stimulus responses and compared to results simultaneously collected by rigid dry Ag/AgCl electrodes. Results: A repeatable fabrication process for flexible Ag/AgCl electrodes has been established. Surface area, distance between and geometry of electrodes are shown to affect the detectability of the EDA response and the minimum number of sweat glands to be covered by the electrodes has been estimated at 140, or more, in order to maintain functionality. The optimal flexible EDA electrode is a serpentine design with a 0.15 cm2 surface area and a 0.20 cm distance with an average Pearson correlation coefficient of $\text{0.979} \pm \text{0.015}$ . Conclusion: Fabrication of flexible electrodes is described and an understanding of the effects of electrode designs on the EDA stimulus response detection has been established and is potentially related to the coverage of sweat glands. Significance: This work presents a novel systematic approach to understand the effects of electrode designs on monitoring EDA which is of importance for the design of wearable EDA monitoring devices.
Crystal structure of 1,1′-bis[1,7-dicarba-closo-dodecaborane(11)]

In 1,1′-bis[1,7-dicarba-closo-dodecaborane(11)], the two {1,7-closo-C2B10H11} cages are linked across a centre of inversion. The position of the second non-linking cage C atom was established unambiguously by geometric and crystallographic methods and there is no evidence of C/B disorder.
Entangled agencies, material networks and repair in a building assemblage: the mutable stone of St Ann’s Church, Manchester1

This article explores the fluidities and stabilities of urban materiality by looking at the ongoing emergence of a 300-year-old church in central Manchester. The notion of assemblages is utilised to investigate how places, such as the building featured here, are simultaneously destroyed and altered by numerous agencies, and stabilised by repair and replacement building material. By examining the vital properties of stone and the particular non-human agents that act upon the stony fabric of the building, I explore some of the processes that render matter continuously emergent. I subsequently consider the consequences of these material transformations by looking at how they promote the enrolment of two human processes of spatial (re)ordering, the forging of connections between the city and sites of stone supply, and the changing and contested process of repair and maintenance. I argue that by acknowledging complexity, historical depth and geographical scale, non-human and human entanglements, and ambiguity, we might write accounts that do justice to the emergence, contingency and unpredictability in a world of innumerable agencies.
Malicious-Client Security in Blind Seer: A Scalable Private DBMS

The Blind Seer system (Oakland 2014) is an efficient and scalable DBMS that affords both client query privacy and server data protection. It also provides the ability to enforce authorization policies on the system, restricting client's queries while maintaining the privacy of both query and policy. Blind Seer supports a rich query set, including arbitrary boolean formulas, and is provably secure with respect to a controlled amount of search pattern leakage. No other system to date achieves this tradeoff of performance, generality, and provable privacy. A major shortcoming of Blind Seer is its reliance on semi-honest security, particularly for access control and data protection. A malicious client could easily cheat the query authorization policy and obtain any database records satisfying any query of its choice, thus violating basic security features of any standard DBMS. In sum, Blind Seer offers additional privacy to a client, but sacrifices a basic security tenet of DBMS. In the present work, we completely resolve the issue of a malicious client. We show how to achieve robust access control and data protection in Blind Seer with virtually no added cost to performance or privacy. Our approach also involves a novel technique for a semi-private function secure function evaluation (SPF-SFE) that may have independent applications. We fully implement our solution and report on its performance.
Staphylococcus aureus infection induced redox signaling and DNA fragmentation in T-lymphocytes: possible ameliorative role of nanoconjugated vancomycin

Staphylococcus aureus is most frequently isolated pathogen causing bloodstream infections, skin and soft tissue infections and pneumonia. Vancomycin sensitive and resistant S. aureus infection causes oxidative stress in neutrophils and lymphocytes. Lymphocyte is an important immune cell. The immune cells use reactive oxygen species (ROS) for carrying out their normal functions while an excess amount of ROS can attack cellular components that lead to cell damage. The aim of the present study was to test the protective role of nanoconjugated vancomycin against Vancomycin Sensitive S. aureus (VSSA) and Vancomycin Resistant S. aureus (VRSA) infection induced oxidative stress in T-lymphocytes. VSSA and VRSA infection were developed in Swiss mice by intraperitoneal injection of 5 × 106 CFU/ml bacterial solutions. Nanoconjugated vancomycin was treated to VSSA and VRSA infected mice at a dose of 100 mg/kg bw/day and 500 mg/kg bw/day, respectively for successive 10 days. Vancomycin was treated to VSSA and VRSA infected mice at similar dose, respectively, for 10 days. The result of this study reveals that in vivo VSSA and VRSA infection significantly increases the level of nitrite generation, lipid peroxidation, protein oxidation, oxidized glutathione level, DNA fragmentation, and decreases the level of reduced glutathione, antioxidant enzyme status, glutathione dependent enzymes as compared to control group; which were increased or decreased significantly near to normal in T-lymphocytes of nanoconjugated vancomycin treated group. These finding suggests the potential use and beneficial protective role of nanoconjugated vancomycin against VSSA and VRSA infection induced oxidative stress in T-lymphocytes.
Finding test data with specific properties via metaheuristic search

For software testing to be effective the test data should cover a large and diverse range of the possible input domain. Boltzmann samplers were recently introduced as a systematic method to randomly generate data with a range of sizes from combinatorial classes, and there are a number of automated testing frameworks that serve a similar purpose. However, size is only one of many possible properties that data generated for software testing should exhibit. For the testing of realistic software systems we also need to trade off between multiple different properties or search for specific instances of data that combine several properties. In this paper we propose a general search-based framework for finding test data with specific properties. In particular, we use a metaheuristic, differential evolution, to search for stochastic models for the data generator. Evaluation of the framework demonstrates that it is more general and flexible than existing solutions based on random sampling.
Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat.

1. The role of serotonin (5‐HT) and excitatory amino‐acids (EAAs) in the activation of the neural networks (i.e. the central pattern generators) that organize locomotion in mammals was investigated in an isolated brainstem‐spinal cord preparation from the newborn rat. 2. The neuroactive substances were bath applied and the activity of fictive locomotion was recorded in the ventral roots. 3. Serotonin initiated an alternating pattern of right and left action potential bursts. The period of this rhythm was dose dependent, i.e. it decreased from around 10 s at 2 x 10(‐5) M to 5 s at 10(‐4) M. The effects of serotonin were blocked by a 5‐HT1 antagonist (propranolol) and by 5‐HT2 antagonists (ketanserin, cyproheptadine, mianserin). 5‐HT3 antagonists were ineffective. The effects of methoxytryptamine, a non‐selective 5‐HT agonist, mimicked the 5‐HT effects. 4. The endogenous EAAs, glutamate and aspartate, also triggered an alternating rhythmic pattern. Their effects were blocked by 2‐amino‐5‐phosphonovaleric acid (AP‐5; a N‐methyl‐D‐aspartate (NMDA) receptor blocker) and 6,7‐dinitro‐quinoxaline‐2,3‐dione (a non‐NMDA receptor blocker). 5. Several EAA agonists (N‐methyl‐D,L‐aspartate (NMA) and kainate) initiated rhythmic activity. The period of the induced rhythm (from 3 to 1 s) was similar with both of these substances but in a range of concentrations which was ten times lower in the case of kainate (10(‐6) to 5 x 10(‐6) M) than in that of NMA (10(‐5) to 4 x 10(‐5) M). alpha‐Amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate and quisqualate occasionally triggered some episodes of fictive locomotion with a threshold at 6 x 10(‐7) and 10(‐5) M, respectively.