Miracle-dz/UniFAR-FTUs huggingface dataset:
Technology-driven limits on DVFS controllability of multiple voltage-frequency island designs: A system-level perspective

In this paper, we consider the case of network-on-chip (NoC) based multiple processor systems-on-chip (MPSoCs) implemented using multiple voltage and frequency islands (VFIs) that rely on fine grained dynamic voltage and frequency scaling (DVFS) for run time control of the system power dissipation. Specifically, we present a framework to compute theoretical bounds on the performance of DVFS controllers for such systems under the impact of three important technology driven constraints: reliability and temperature driven upper limits on the maximum supply voltage; inductive noise driven constraints on the maximum rate of change of voltage/frequency; and increasing manufacturing process variations. Our experimental results show that, for the benchmarks considered, any DVFS control algorithm will lose up to 87% performance, measured in terms of the number of steps required to reach a reference steady state, in the presence of maximum frequency and maximum frequency increment constraints. In addition, increasing process variations can lead to up to 60% of fabricated chips being unable to meet the specified DVFS control specifications, irrespective of the DVFS algorithm used.
Can Relationality be Distinguished from Abstractness in Noun Mutability ?

Previous studies have suggested that relational concepts are more mutable—more prone to change meaning in context— than entity concepts even when both relational and entity concepts are denoted by nouns (Asmuth & Gentner, 2005; Feist & Férez, 2007). However, relationality is a complex dimension, and is highly correlated with other factors such as imageability and abstractness. In the current research, we compared the mutability of entity nouns and relational nouns while controlling for imageability (as well as frequency). People read these nouns in a given context and then had to recognize them in either the same or different context. We found that (1) participants showed greater recognition sensitivity for entity nouns than for relational nouns; and (2) recognition of relational nouns was more impaired by a change in context than was recognition of entity nouns. We conclude that the encoding of relational nouns is more influenced by context than the encoding of entity nouns and discuss parallels with encoding patterns for verbs and nouns.
Fundamentals of Order Dependencies

Dependencies have played a significant role in database design for many years. They have also been shown to be useful in query optimization. In this paper, we discuss dependencies between lexicographically ordered sets of tuples. We introduce formally the concept of order dependency and present a set of axioms (inference rules) for them. We show how query rewrites based on these axioms can be used for query optimization. We present several interesting theorems that can be derived using the inference rules. We prove that functional dependencies are subsumed by order dependencies and that our set of axioms for order dependencies is sound and complete.
WiFi access point deployment for efficient mobile data offloading

Recently, there has been a tremendous increase in mobile data usage with the wide-spread proliferation of smartphone like devices. However, this increased demand from users has caused severe traffic overloading in cellular networks. Offloading the traffic through several other devices (femtocells, WiFi access points) have been considered to be immediate remedy for such a problem. Thus, in this paper, we study the deployment of WiFi access points (AP) in a metropolitan area for efficient offloading of mobile data traffic. We analyze a large scale real user mobility traces and propose a deployment algorithm based on the density of user data request frequency. In simulations, we present offloading ratio that our algorithm can accomplish with different number of APs. The results demonstrate that our algorithm can achieve close to optimal offloading ratio that is higher than offloading ratios that existing algorithms can achieve with the same number of APs.
Standard Making: a Critical Research Frontier for Information Systems Misq Special Issue Workshop the Adoption and Diffusion of Interorganizational System Standards and Process Innovations

Interorganizational system standards are reaching a new era in industry. When asked about interorganizational systems, invariably most people think of electronic data interchange (EDI) standards (ANSI X12). Albeit EDI still remains the preeminent type of interorganizational system, IOS solutions have been overhauled since the mid-1990s. IOS solutions are now collaboratively developed, structured around discretely defined cross-company business process standards and able to be distributed via the web. Compared with EDI technology from the past, the notions of open standards, modularity, scalability, and interorganizational business process reengineering have become embedded in modern-day IOS development. This paper is intended to examine assimilation levels of interorganizational system standards and process innovations (IOS SPI) among members of an industrial group where an IOS standards development organization (SDO) exists. A Conceptual IOS SPI Adoption and Innovation Diffusion Model is developed, defined and nine hypotheses are proposed and empirically tested based on firm-level cross-sectional surveys of 102 firms from 10 different industrial groups (encompassing 15 different SDOs). Using the organizational-technological-environmental framework (with the addition of the SDO construct), the significant determinants of IOS SPI adoption were found to be; top management support, feasibility, technology conversion, competitive pressure, SDO participation level, and SDO Architecture. Using the same framework, the significant determinants of IOS SPI deployment were found to be; feasibility, competitive pressure, SDO participation level, compatibility, shared business process attributes, SDO Architecture and SDO Governance. A rich discussion is then provided regarding findings in the areas of industrial coordination of IOS standards, consequences of IOS standards diffusion, and SDO measures of success (including governance and management practices). Numerous recommendations are provided to practitioners and researchers for future consideration in this critically important and emerging research frontier. INTRODUCTION Interorganizational system standards are reaching a new era in industry. An era that could be on the verge of immense widespread diffusion. When asked about interorganizational system standards, invariably most people think of electronic data interchange (EDI) standards (ANSI X12). Albeit EDI still remains the preeminent type of interorganizational system, IOS solutions have been overhauled since the mid-1990s. IOS solutions are now collaboratively developed, structured around discretely defined cross-company business process standards and able to be
Association between tissue miR-141, miR-200c and miR-30b and bladder cancer: a matched case-control study.

PURPOSE To evaluate the expression of microRNAs in tissue samples from patients with bladder cancer and to compare it with healthy adjacent tissue samples as controls. MATERIALS AND METHODS Thirty five tissue samples from patients with newly diagnosed untreated bladder transitional cell carcinoma and 35 adjacent normal urothelium were collected during 2013 to 2014. TRIzol reagent was used to isolate total RNA including microRNAs. RNA concentration and purity were determined using a nanodrop spectrophotometer. Also 1% agarose gel electrophoresis was used to assess integrity of RNA. Real-Time Quantitative Reverse Transcription PCR (qRT-PCR) method was performed using the PARSGENOME microRNA RT-PCR system. Data was analyzed by STATA 11. RESULTS A couple of patients were female the remainder were male. Mean age of patients were 71.06 ± 11.43 years. The expression level of miR-30b, miR-141 and miR-200c in case group were significantly higher than that of control normal tissue samples. miR-141 had higher expression rate in malignant tissue than two other miRNAs (P < .001). CONCLUSION There was a more expression rate of miR-200c, miR-141 and miR-30b in bladder cancer tissues than healthy adjacent control tissues. Further studies are needed to draw final conclusion.
A 135–170 GHz power amplifier in an advanced sige HBT technology

Summary form only given. High-power, broadband power amplifiers (PA) operating in the D-band (110-170 GHz) are essential towards implementation of broadband frequency multiplier chains at sub-mmWave frequencies. In this paper we present the design of a 3-stage power amplifier (PA) with 3-dB bandwidth of 35 GHz (135-170 GHz) and implemented in 130 nm SiGe BiCMOS technology. A staggered tuning approach where the peak gain of the individual or group of individual stages are tuned at offset frequencies is used for broadband operation. In the 135-170 GHz, the small signal gain for the PA is 14-17 dB and the saturated output power (Psat) varies from 5-8 dBm and the output referred 1 dB compression point (P1dB) varies from 1-6 dBm over this frequency range. The nominal dc power consumption of this PA is 320 mW with peak PAE of 1.6%. To our best knowledge, this is the highest bandwidth reported for silicon PAs in the D band.
Benders decomposition for local access network design with two technologies

We have worked with the local access network design problem with two cable technologies. This is an optimization problem in graphs that consists of linking an origin node to a set of terminal nodes which have a flow demand. There are also a set of Steiner or transshipment nodes which do not have demand. Each arc of the graph has two associated costs: a variable cost depending on the flow through the arc and a fixed cost associated with the installation of the arc. Moreover, in each arc we can install one of two available technologies: optical fiber or copper (we can also use radio links with any other cable technology). Each one of these technologies has different variable and fixed costs. To be more precise, the fixed cost of the optical fiber is greater than that of the copper, but its variable cost is much smaller. The problem was modeled using a multicommodity flow formulation in which we added some structural constraints. This model was used to apply the Benders decomposition method. The structural constraints have the objective of trying to guarantee that the master problem of the Benders decomposition will yield a tree. The Benders subproblems are trivial network flow problems. The dual variables have commodity meaningfull values and are evaluated in a systematic form. The algorithm was implemented in C++ with CPLEX 3.0 callable library. We have tested the algorithm with some test instances obtained by a generator of problems that we developed.
Missed or Delayed Medical Care Appointments by Older Users of Nonemergency Medical Transportation.

PURPOSE OF THE STUDY This study identified factors associated with canceling nonemergency medical transportation appointments among older adult Medicaid patients. DESIGN AND METHODS Data from 125,913 trips for 2,913 Delaware clients were examined. Mediation analyses, as well as, multivariate logistic regressions were conducted. RESULTS Over half of canceled trips were attributed to client reasons (e.g., no show, refusal). Client characteristics (e.g., race, sex, functional status) were associated with cancelations; however, these differed based on the cancelation reason. Regularly scheduled trips were less likely to be canceled. IMPLICATIONS The evolving American health care system may increase service availability. Additional policies can improve service accessibility and overcome utilization barriers.
β-Catenin has sequential roles in the survival and specification of ventral dermis

The dermis promotes the development and maintains the functional components of skin, such as hair follicles, sweat glands, nerves and blood vessels. The dermis is also crucial for wound healing and homeostasis of the skin. The dermis originates from the somites, the lateral plate mesoderm and the cranial neural crest. Despite the importance of the dermis in the structural and functional integrity of the skin, genetic analysis of dermal development in different parts of the embryo is incomplete. The signaling requirements for ventral dermal cell development have not been established in either the chick or the mammalian embryo. We have shown previously that Wnt signaling specifies the dorsal dermis from the somites. In this study, we demonstrate that Wnt/β-catenin signaling is necessary for the survival of early ventral dermal progenitors. In addition, we show that, at later stages, Wnt/β-catenin signaling is sufficient for ventral dermal cell specification. Consistent with the different origins of dorsal and ventral dermal cells, our results demonstrate both conserved and divergent roles ofβ -catenin/Wnt signaling in dermal development.
Mouse Oocyte Methylomes at Base Resolution Reveal Genome-Wide Accumulation of Non-CpG Methylation and Role of DNA Methyltransferases

DNA methylation is an epigenetic modification that plays a crucial role in normal mammalian development, retrotransposon silencing, and cellular reprogramming. Although methylation mainly occurs on the cytosine in a CG site, non-CG methylation is prevalent in pluripotent stem cells, brain, and oocytes. We previously identified non-CG methylation in several CG-rich regions in mouse germinal vesicle oocytes (GVOs), but the overall distribution of non-CG methylation and the enzymes responsible for this modification are unknown. Using amplification-free whole-genome bisulfite sequencing, which can be used with minute amounts of DNA, we constructed the base-resolution methylome maps of GVOs, non-growing oocytes (NGOs), and mutant GVOs lacking the DNA methyltransferase Dnmt1, Dnmt3a, Dnmt3b, or Dnmt3L. We found that nearly two-thirds of all methylcytosines occur in a non-CG context in GVOs. The distribution of non-CG methylation closely resembled that of CG methylation throughout the genome and showed clear enrichment in gene bodies. Compared to NGOs, GVOs were over four times more methylated at non-CG sites, indicating that non-CG methylation accumulates during oocyte growth. Lack of Dnmt3a or Dnmt3L resulted in a global reduction in both CG and non-CG methylation, showing that non-CG methylation depends on the Dnmt3a-Dnmt3L complex. Dnmt3b was dispensable. Of note, lack of Dnmt1 resulted in a slight decrease in CG methylation, suggesting that this maintenance enzyme plays a role in non-dividing oocytes. Dnmt1 may act on CG sites that remain hemimethylated in the de novo methylation process. Our results provide a basis for understanding the mechanisms and significance of non-CG methylation in mammalian oocytes.
A threat based approach to computational offloading for collaborative cruise control

The interaction between discrete components of Internet of Things (IoT) and Intelligent Transportation Systems (ITS) is vital for a collaborative system. The secure and reliable use of Cruise Control (CC) with Cloud and Edge Cloud to achieve complete autonomy for a vehicle is a key component and a major challenge for ITS. This research unravels the complications that arise when Adaptive Cruise Control (ACC) is incorporated into a collaborative environment. It mainly answers the question of where to securely compute Collaborative Cruise Control's (CCC) data in a connected environment. To address this, the paper initially reviews previous research in the domain of Vehicular Cloud, ITS architecture, related threat modelling approaches, and secure implementations of ACC. An overview application model for CCC is developed for performing a threat analysis with the purpose of investigating the reasons why a vehicle suffers collision. Through the use of interviews, the research analyses and suggests the location of computational data by creating a taxonomy between the Edge Cloud, Cloud and the On-board Unit (OBU) while validating the model.
Path-guided indoor navigation for the visually impaired using minimal building retrofitting

One of the common problems faced by visually impaired people is of independent path-based mobility in an unfamiliar indoor environment. Existing systems do not provide active guidance or are bulky, expensive and hence are not socially apt. In this paper, we present the design of an omnipresent cellphone based active indoor wayfinding system for the visually impaired. Our system provides step-by-step directions to the destination from any location in the building using minimal additional infrastructure. The carefully calibrated audio, vibration instructions and the small wearable device helps the user to navigate efficiently and unobtrusively. Results from a formative study with five visually impaired individuals informed the design of the system. We then deployed the system in a building and field tested it with ten visually impaired users. The comparison of the quantitative and qualitative results demonstrated that the system is useful and usable, but can still be improved.
Realization of bilateral haptic communication between different DOF systems based on Clarke transformation

This paper proposes a new bilateral motion control method with coordinate transformation for different degrees of freedom (DOF) systems. The proposed method is based on the Clarke transformation which is one of the most basic principles in power electronics. The Clarke transformation can achieve the information conversion between three-phase system and two-phase system. The proposed method based on this principle realizes the haptic communication between three DOF system and two DOF system. The validity of the proposed method is verified by simulation results.
Gesture recognition based on arm tracking for human-robot interaction

In this paper we present a novel approach for hand gesture recognition. The proposed system utilizes upper body part tracking in a 9-dimensional configuration space and two Multi-Layer Perceptron/Radial Basis Function (MLP/RBF) neural network classifiers, one for each arm. Classification is achieved by buffering the trajectory of each arm and feeding it to the MLP Neural Network which is trained to recognize between five gesturing states. The RBF neural network is trained as a predictor for the future gesturing state of the system. By feeding the output of the RBF back to the MLP classifier, we achieve temporal consistency and robustness to the classification results. The proposed approach has been assessed using several video sequences and the results obtained are presented in this paper.
Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis

The frontline tuberculosis drug isoniazid (INH) inhibits InhA, the NADH‐dependent fatty acid biosynthesis (FAS‐II) enoyl reductase from Mycobacterium tuberculosis (MTB), via formation of a covalent adduct with NAD+ (the INH‐NAD adduct). Resistance to INH can be correlated with many mutations in MTB, some of which are localized in the InhA cofactor binding site. While the InhA mutations cause a substantial decrease in the affinity of InhA for NADH, surprisingly the same mutations result in only a small impact on binding of the INH‐NAD adduct. Based on the knowledge that InhA interacts in vivo with other components of the FAS‐II pathway, we have initiated experiments to determine whether enzyme inhibition results in structural changes that could affect protein–protein interactions involving InhA and how these ligand‐induced conformational changes are modulated in the InhA mutants. Significantly, while NADH binding to wild‐type InhA is hyperbolic, the InhA mutants bind the cofactor with positive cooperativity, suggesting that the mutations permit access to a second conformational state of the protein. While cross‐linking studies indicate that enzyme inhibition causes dissociation of the InhA tetramer into dimers, analytical ultracentrifugation and size exclusion chromatography reveal that ligand binding causes a conformational change in the protein that prevents cross‐linking across one of the dimer–dimer interfaces in the InhA tetramer. Interestingly, a similar ligand‐induced conformational change is also observed for the InhA mutants, indicating that the mutations modulate communication between the subunits without affecting the two conformational states of the protein that are present.
Cluster based Ranking Index for Enhancing Recruitment Process using Text Mining and Machine Learning

This paper presents an effective approach for extracting relevant words from the resumes using Term Document Matrix. The role of the candidate, various skills, familiarity with various frameworks, experienced skills and operating systems have been considered. A clustering methodology has been used to find the similar resumes. The importance of each word has been calculated according to the cluster which makes this paper unique. The appropriate rank of the resumes have been calculated. The experimental results shows that Cluster Based Ranking gives the potentially best candidate for a particular job profile. The weighted importance in calculating the ranks is the very first effort in itself. Further work can be done in this area for improving the productivity in the recruitment process.
Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3−/− Mice

The pathogenesis of Crohn's disease (CD) involves defects in the innate immune system, impairing responses to microbes. Studies have revealed that mutations NLRP3 are associated with CD. We reported previously that Nlrp3−/− mice were more susceptible to colitis and exhibited reduced colonic IL-10 expression. In the current study, we sought to determine how the loss of NLRP3 might be altering the function of regulatory T cells, a major source of IL-10. Colitis was induced in wild-type (WT) and Nlrp3−/− mice by treatment with dextran sulphate sodium (DSS). Lamina propria (LP) cells were assessed by flow cytometry and cytokine expression was assessed. DSS-treated Nlrp3−/− mice exhibited increased numbers of colonic foxp3+ T cells that expressed significantly lower levels of IL-10 but increased IL-17. This was associated with increased expression of colonic IL-15 and increased surface expression of IL-15 on LP dendritic cells. Neutralizing IL-15 in Nlrp3−/− mice attenuated the severity of colitis, decreased the number of colonic foxp3+ cells, and reduced the colonic expression of IL-12p40 and IL-17. These data suggest that the NLRP3 inflammasome can regulate intestinal inflammation through noncanonical mechanisms, providing additional insight as to how NLRP3 variants may contribute to the pathogenesis of CD.
Progressive histogram reshaping for creative color transfer and tone reproduction

Image manipulation takes many forms. A powerful approach involves image adjustment by example. To make color edits more intuitive, the intelligent transfer of a user-specified target image's color palette can achieve a multitude of creative effects, provided the user is supplied with a small set of straightforward parameters. We present a novel histogram reshaping technique which allows significantly more control than previous methods. Given that the user is free to chose any image as the target, the process of steering the algorithm becomes artistic. Moreover, we show for the first time that creative tone reproduction can be achieved by matching a high dynamic range image against a low dynamic range target.