Miracle-dz/UniFAR-FTUs huggingface dataset:
Generalization Bounds in the Predict-then-Optimize Framework

The predict-then-optimize framework is fundamental in many practical settings: predict the unknown parameters of an optimization problem and then solve the problem using the predicted values of the parameters. A natural loss function in this environment is to consider the cost of the decisions induced by the predicted parameters in contrast to the prediction error of the parameters. This loss function is referred to as the smart predict-then-optimize (SPO) loss. In this work, we seek to provide bounds on how well the performance of a prediction model fit on training data generalizes out of sample in the context of the SPO loss. Because the SPO loss is nonconvex and non-Lipschitz, standard results for deriving generalization bounds do not apply. We first derive bounds based on the Natarajan dimension that, in the case of a polyhedral feasible region, scale at most logarithmically in the number of extreme points but, in the case of a general convex feasible region, have linear dependence on the decision dimension. By exploiting the structure of the SPO loss function and a key property of the feasible region, which we denote as the strength property, we can dramatically improve the dependence on the decision and feature dimensions. Our approach and analysis rely on placing a margin around problematic predictions that do not yield unique optimal solutions and then providing generalization bounds in the context of a modified margin SPO loss function that is Lipschitz continuous. Finally, we characterize the strength property and show that the modified SPO loss can be computed efficiently for both strongly convex bodies and polytopes with an explicit extreme point representation. Funding: O. El Balghiti thanks Rayens Capital for their support. A. N. Elmachtoub acknowledges the support of the National Science Foundation (NSF) [Grant CMMI-1763000]. P. Grigas acknowledges the support of NSF [Grants CCF-1755705 and CMMI-1762744]. A. Tewari acknowledges the support of the NSF [CAREER grant IIS-1452099] and a Sloan Research Fellowship.
Poincaré constraints on the gravitational form factors for massive states with arbitrary spin

In this work we analyse the constraints imposed by Poincar\'e symmetry on the gravitational form factors appearing in the Lorentz decomposition of the energy-momentum tensor matrix elements for massive states with arbitrary spin. By adopting a distributional approach, we prove for the first time non-perturbatively that the zero momentum transfer limit of the leading two form factors in the decomposition are completely independent of the spin of the states. It turns out that these constraints arise due to the general Poincar\'e transformation and on-shell properties of the states, as opposed to the specific characteristics of the individual Poincar\'e generators themselves. By expressing these leading form factors in terms of generalised parton distributions, we subsequently derive the linear and angular momentum sum rules for states with arbitrary spin.
A Graph Theoretic Framework of Recomputation Algorithms for Memory-Efficient Backpropagation

Recomputation algorithms collectively refer to a family of methods that aims to reduce the memory consumption of the backpropagation by selectively discarding the intermediate results of the forward propagation and recomputing the discarded results as needed. In this paper, we will propose a novel and efficient recomputation method that can be applied to a wider range of neural nets than previous methods. We use the language of graph theory to formalize the general recomputation problem of minimizing the computational overhead under a fixed memory budget constraint, and provide a dynamic programming solution to the problem. Our method can reduce the peak memory consumption on various benchmark networks by 36%~81%, which outperforms the reduction achieved by other methods.
Students’ Psychological Adjustment in Normative School Transitions From Kindergarten to High School: Investigating the Role of Teacher-Student Relationship Quality

School transitions require students to adapt to new challenges and situations and can increase the risk of externalizing and internalizing psychological symptoms. The teacher-student relationship seems to be a protective factor for the risk of developing psychological symptoms during school transitions. The aim of the present study is to investigate whether the quality of the teacher-student relationship predicts the decrease of internalizing and externalizing symptoms during three school transitions, namely: from kindergarten to primary school (T1), from primary to middle school (T2), and from middle to high school (T3). We recruited 127 kindergarten students (mean age = 5.40, SD = 0.49), 113 fifth grade primary school students (mean age = 10.64, SD = 0.54), and 240 eighth grade students (mean age = 13.88, SD = 0.37) and their teachers (response rate = 95%). Data were collected from 2016 to 2018. Teachers filled out an anonymous survey, acting as informants for the students, reporting demographic details (age, gender), psychological symptoms, and quality of the teacher-student relationship. The data show that a positive teacher-student relationship quality tends to be associated with a reduction of psychological symptoms. A stable, low-conflict teacher-student relationship was confirmed as a protective factor from increased internalizing and externalizing symptoms during all normative school transitions. Furthermore, we see that an increase in teacher-student conflict during the transitions from primary to middle school, and from middle to high school is linked to an exacerbation in students’ externalizing symptoms during the first year of attendance of the new school. Our study confirms the importance of the teacher-student relationship in reducing psychological symptoms associated with school transitions, in every type of transition, favoring an improved psychological adjustment to the new environment. A positive teacher-student relationship represents a protective factor for the development of students. Study limitations are discussed.
Characterization of 15 nuclear microsatellite markers for Afzelia africana (Fabaceae) and related species

Premise Afzelia africana (Fabaceae) is a valuable, internationally vulnerable tree species in tropical Africa. The development of specific simple sequence repeat (SSR) loci is necessary for population genetic studies in this tree species and its closest relatives. Methods And Results Fifteen new polymorphic microsatellite markers were developed for A. africana using Illumina next‐generation sequencing. We tested the polymorphism of the 15 loci in three populations in Benin, West Africa. The number of expressed alleles per locus varied from one to 12. The levels of observed and expected heterozygosity ranged from 0.100 to 1.000 and from 0.095 to 0.882, respectively. Most markers successfully amplified in the closely related species A. quanzensis and A. bipindensis, but less so in A. bipindensis. Conclusions Because of their cross‐amplification ability, these newly developed loci will serve as useful tools for future molecular analyses on A. africana and related species.
Effects of Obesity on Pulmonary Inflammation and Remodeling in Experimental Moderate Acute Lung Injury

Obese patients are at higher risk of developing acute respiratory distress syndrome (ARDS); however, their survival rates are also higher compared to those of similarly ill non-obese patients. We hypothesized that obesity would not only prevent lung inflammation, but also reduce remodeling in moderate endotoxin-induced acute lung injury (ALI). Obesity was induced by early postnatal overfeeding in Wistar rats in which the litter size was reduced to 3 pups/litter (Obese, n = 18); Control animals (n = 18) were obtained from unculled litters. On postnatal day 150, Control, and Obese animals randomly received E. coli lipopolysaccharide (ALI) or saline (SAL) intratracheally. After 24 h, echocardiography, lung function and morphometry, and biological markers in lung tissue were evaluated. Additionally, mediator expression in neutrophils and macrophages obtained from blood and bronchoalveolar lavage fluid (BALF) was analyzed. Compared to Control-SAL animals, Control-ALI rats showed no changes in echocardiographic parameters, increased lung elastance and resistance, higher monocyte phagocytic capacity, collagen fiber content, myeloperoxidase (MPO) activity, and levels of interleukin (IL-6), tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, and type III (PCIII), and I (PCI) procollagen in lung tissue, as well as increased expressions of TNF-α and monocyte chemoattractant protein (MCP)-1 in blood and BALF neutrophils. Monocyte (blood) and macrophage (adipose tissue) phagocytic capacities were lower in Obese-ALI compared to Control-ALI animals, and Obese animals exhibited reduced neutrophil migration compared to Control. Obese-ALI animals, compared to Obese-SAL, exhibited increased interventricular septum thickness (p = 0.003) and posterior wall thickness (p = 0.003) and decreased pulmonary acceleration time to pulmonary ejection time ratio (p = 0.005); no changes in lung mechanics, IL-6, TNF-α, TGF-β, PCIII, and PCI in lung tissue; increased IL-10 levels in lung homogenate (p = 0.007); reduced MCP-1 expression in blood neutrophils (p = 0.009); decreased TNF-α expression in blood (p = 0.02) and BALF (p = 0.008) neutrophils; and increased IL-10 expression in monocytes (p = 0.004). In conclusion, after endotoxin challenge, obese rats showed less deterioration of lung function, secondary to anti-inflammatory and anti-fibrotic effects, as well as changes in neutrophil and monocyte/macrophage phenotype in blood and BALF compared to Control rats.
Carbon and Nitrogen Concentrations, Stocks, and Isotopic Compositions in Red Sea Seagrass and Mangrove Sediments

Coastal vegetated ecosystems are intense global carbon (C) sinks; however, seagrasses and mangroves in the Central Red Sea are depleted in organic C (Corg). Here, we tested whether Corg depletion prevails across the whole Red Sea, or if sediment Corg and nitrogen (N) stocks reflect the latitudinal productivity gradient of the Red Sea. We assessed Corg and N concentrations, stocks, isotopic compositions (δ13C and δ15N), and the potential contribution of primary producers to the organic matter accumulation in seagrass and mangrove sediments along the Eastern coast of the Red Sea. Sediment Corg concentration was higher in mangroves than seagrasses, while N concentrations were similar, resulting in higher C/N ratios in mangrove than seagrass sediments. Mangrove Corg stocks (integrated over the top 10 cm) were two-fold higher than those of seagrasses, respectively. N concentrations and stocks decreased from south to north in seagrass sediments matching the productivity gradient while Corg concentrations and stocks were uniform. The δ15N decreased from south to north in seagrass and mangrove sediments, reflecting a shift from nitrate and nitrite as N sources in the south, to N2 fixation towards the north. Stable isotope mixing models showed that seagrass leaves and macroalgae blades were the major contributors to the organic matter accumulation in seagrass sediments; while mangrove leaves were the major contributors in mangrove sediments. Overall, vegetated sediments in the Red Sea tend to be carbonate-rich and depleted in Corg and N, compared to coastal habitats elsewhere. Specifically, mean Corg stocks in Red Sea seagrass and mangrove sediments (7.2 ± 0.4 and 14.5 ± 1.4 Mg C ha-1, respectively) are lower than previously reported mean global values. This new information of Blue Carbon resources in the Red Sea provides a background for Blue Carbon programs in the region while also helping to balance global estimates.
Experiences of localization and removal of non-palpable subdermal contraceptive implants with ultrasound

Objective The aim of this study was to present experiences in localization and removal of non-palpable subdermal contraceptive implants with ultrasonography. Methods Medical records from January 1, 2016, to April 30, 2018, were retrospectively reviewed for 21 patients who were referred to a single institution and had an impalpable implant despite following the removal instruction. In all the cases, more than one attempt was made to remove the implant before referral. The rod was detected using radiography and ultrasonography. In all the cases, localization of the single implant was achieved with ultrasonography. The distal depth of the rod was measured, and skin marking was made following the echogenicity. The implants were subsequently removed under anesthesia. Results In 18 cases, the rods were localized using ultrasonography and successfully removed under local anesthesia. In the other three cases, removal with local anesthesia failed. Although the rod was detected successful with ultrasonography, the implants were removed under general anesthesia in the operating room. The depth from skin to rod, measured with ultrasonography, was >12.0 mm in all the cases and located deep in the muscular layer in the failure cases. The depth of the implants positively correlated with the time spent for removal (r=0.525; P=0.015). Conclusion High frequency ultrasonography is a highly accurate tool for localization and measurement of the skin-to-rod depth. It is also useful for removing non-palpable implants. If the depth of the implant is >12.0 mm, removal of the implant in the operating room under general anesthesia is recommended.
Increased CD14+HLA-DR−/low Myeloid-Derived Suppressor Cells Correlate With Disease Severity in Systemic Lupus Erythematosus Patients in an iNOS-Dependent Manner

Myeloid-derived suppressor cells (MDSCs) comprise of a population of cells, which suppress the innate and adaptive immune system via different mechanisms. MDSCs are accumulated under pathological conditions. The present study aimed to clarify the pathological role of MDSCs in systemic lupus erythematosus (SLE) patients. Consequently, the level of circulating M-MDSCs was significantly increased in newly diagnosed SLE patients as compared to healthy controls. An elevated level of M-MDSCs was positively correlated with the disease severity in SLE patients and an immunosuppressive role was exerted in an iNOS-dependent manner. The decrease in the number of M-MDSCs after therapy rendered them as an indicator for the efficacy of treatment. These results demonstrated that M-MDSCs participated in the pathological progress in SLE patients. Thus, MDSCs are attractive biomarkers and therapeutic targets for SLE patients.
Learning of Proto-object Representations via Fixations on Low Resolution

While previous researches in eye fixation prediction typically rely on integrating low-level features (e.g. color, edge) to form a saliency map, recently it has been found that the structural organization of these features into a proto-object representation can play a more significant role. In this work, we present a computational framework based on deep network to demonstrate that proto-object representations can be learned from low-resolution image patches from fixation regions. We advocate the use of low-resolution inputs in this work due to the following reasons: (1) Proto-objects are computed in parallel over an entire visual field (2) People can perceive or recognize objects well even it is in low resolution. (3) Fixations from lower resolution images can predict fixations on higher resolution images. In the proposed computational model, we extract multi-scale image patches on fixation regions from eye fixation datasets, resize them to low resolution and feed them into a hierarchical. With layer-wise unsupervised feature learning, we find that many proto-objects like features responsive to different shapes of object blobs are learned out. Visualizations also show that these features are selective to potential objects in the scene and the responses of these features work well in predicting eye fixations on the images when combined with learned weights.
Better Than Its Reputation? Gossip and the Reasons Why We and Individuals With “Dark” Personalities Talk About Others

Gossip is an ubiquitous phenomenon. Hearing information about others serves important social functions such as learning without direct interaction and observation. Despite important social functions gossip has a rather negative reputation. Therefore, the present online study focuses on the reasons why people gossip and how these reasons are related to personality (i.e., dark triad) and situational settings. Six distinct motives were identified that underlie gossip behavior: information validation, information gathering, relationship building, protection, social enjoyment, and negative influence. The most important motive was validating information about the gossip target followed by the motive to acquire new information about the gossip target. The least important motive was harming the gossip target. The motivational pattern was highly similar between private and work context. Interestingly, the importance of motives mainly depends on the gossiper's narcissism both in work and in private settings. The findings suggest that the negative reputation of gossip is not justified. In fact, even “dark” personalities appear to use gossip to tune their picture of other humans and themselves and not to harm others.
First report on extended distance between tumor lesion and adjacent organs at risk using interventionally applied balloon catheters: a simple procedure to optimize clinical target volume covering effective isodose in interstitial high-dose-rate brachytherapy of liver malignomas

Purpose Organs at risk (OARs), which are very close to a clinical target volume (CTV), can compromise effective tumor irradiation. The present study investigated the feasibility and safety of a novel approach, in particular, the extent of the dosimetric effect of distancing CTV from adjacent OARs by means of interventionally applied balloon catheters. Material and methods Patients with peripheral hepatic malignancies, in whom the critical proximity of an OAR to the CTV in the assessment by contrast-enhanced magnetic resonance imaging (MRI) scans and the preplanning process were included. Additionally, patients underwent placement of an interventional balloon catheter during computed tomography (CT)-guided application of interstitial brachytherapy (iBT) catheters inserted into the tissue between hepatic capsule and adjacent OAR. The virtual position of an OAR without balloon catheter was anticipated and contoured in addition to contouring of CTV and OAR. The calculated dose values for CTV as well as 1 cc of the relevant OAR (D1cc) with and without balloon were recorded. The D1cc of the realized irradiation plan was statistically compared to the D1cc of the virtually contoured OARs. Results In 31 cases, at least one balloon catheter was administered. The mean D1cc of the OAR in the group with balloon(s) was 12.6 Gy compared with 16 Gy in the virtual cohort without the device, therefore significantly lower (p < 0.001). Overall, there were no acute complications. Severe (> 2 CTCAEv4.03) late complications observed in 3/31 (9.6%) patients during follow-up period after brachytherapy were most certainly not due to the balloon application. Side effects were probably associated with pre-existing serious diseases and potentially additional local late effects of the irradiation in general rather than with the balloon catheters. Conclusions The distancing of the adjacent OARs allows a higher D100 value of CTV, therefore allowing for more efficient local control.
The Wnt/β-Catenin/LEF1 Pathway Promotes Cell Proliferation at Least in Part Through Direct Upregulation of miR-17-92 Cluster

The miR-17-92 cluster is involved in animal development and homeostasis, and its dysregulation leads to human diseases such as cancer. In the present study, we investigated the functional link between miR-17-92 cluster and Wnt/β-catenin signaling pathway in ICP2 and DF1 cells. We demonstrated that ectopic expression of either LEF1 or β-catenin increased the promoter activity of the miR-17-92 cluster host gene (MIR17HG) and combined ectopic expression of LEF1 and β-catenin further enhanced the promoter activity; while knockdown of either LEF1 or β-catenin reduced the MIR17HG promoter activity. Both LEF1 and β-catenin could directly bind to the MIR17HG promoter. Furthermore, we demonstrated that low doses of lithium chloride (LiCl), an activator of Wnt/β-catenin signaling pathway, increased MIR17HG promoter activity and the endogenous expression of the miR-17-92 cluster, while high doses of LiCl had the opposite effects. Treatment with XAV-939, an inactivator of the Wnt/β-catenin pathway, reduced the endogenous expression of miR-17-92 cluster. Finally, we found that low doses of LiCl promoted the proliferation of ICP2 and DF1 cells, while high doses of LiCl inhibited the proliferation of ICP2 and DF1 cells. Taken together, our results reveal that MIR17HG is a target of LEF1 and the Wnt/β-catenin pathway and suggest that the miR-17-92 cluster may, at least in part, mediate the proliferation-promoting effect of the Wnt/β-catenin pathway in cell proliferation.
Culture Modulates the Neural Correlates Underlying Risky Exploration

Most research on cultural neuroscience focuses on one dimension of culture: group membership or individual orientation. However, it is especially important to examine the intersection between the two to better understand the acculturation process. To examine the role of culture in the neural correlates of risky exploration, the current study recruited 22 American and 24 Chinese international students. Participants reported on their independent self-construal, a measure defining the self in terms of emphasizing unique attributes, and underwent an functional magnetic resonance imaging (fMRI) scan while completing a risk-taking task. At the group level, American (vs. Chinese) participants showed greater risky exploration on the task. Moreover, while independent self-construal was not related to American individuals’ behavioral performance and neural correlates of risky exploration, Chinese participants who reported greater independent self-construal recruited greater activation in regions of the cognitive control system [e.g., dorsolateral prefrontal cortex (DLPFC)] and affective system [e.g., anterior insula (AI)], which was related to greater risky exploration. Taken together, our findings suggest that culture as group membership and individual orientation may interact with each other and relate to neural systems underlying risky exploration. This study highlights the importance of studying the role of culture at both group and individual level, which is particularly critical to understand individuals as they acculturate to a new environment.
Assistive Arm-Exoskeleton Control Based on Human Muscular Manipulability

This paper introduces a novel control framework for an arm exoskeleton that takes into account force of the human arm. In contrast to the conventional exoskeleton controllers where the assistance is provided without considering the human arm biomechanical force manipulability properties, we propose a control approach based on the arm muscular manipulability. The proposed control framework essentially reshapes the anisotropic force manipulability into the endpoint force manipulability that is invariant with respect to the direction in the entire workspace of the arm. This allows users of the exoskeleton to perform tasks effectively in the whole range of the workspace, even in areas that are normally unsuitable due to the low force manipulability of the human arm. We evaluated the proposed control framework with real robot experiments where subjects wearing an arm exoskeleton were asked to move a weight between several locations. The results show that the proposed control framework does not affect the normal movement behavior of the users while effectively reduces user effort in the area of low manipulability. Particularly, the proposed approach augments the human arm force manipulability to execute tasks equally well in the entire workspace of the arm.