Miracle-dz/UniFAR-FTUs huggingface dataset:
An evaluation of approximate network optimization methods for improving ip-level fast protection with loop-free alternates

Demand for fast failure recovery in modern IP-based networks has become compelling recently. Loop-Free Alternates (LFA) is a simple IP Fast ReRoute (IPFRR) specification proposed by the IETF that does not require profound changes to the network infrastructure before deployment. However this simplicity has a disadvantage, in that usually LFA does not provide complete protection for all possible failure cases in a general topology. The LFA graph extension problem asks for adding new links to the network in an attempt to improve the failure case coverage. Unfortunately, this problem is NP-complete. In this paper, we give a detailed graph model for this problem, for the first time formulating it both for the link and node protecting cases, and we propose several fast approximation algorithms to solve it. We compare the performance of the algorithms in extensive numerical studies and we conclude that the optimum can be approximated well in most cases relevant to practice.
Human DNA Glycosylase NEIL1’s Interactions with Downstream Repair Proteins Is Critical for Efficient Repair of Oxidized DNA Base Damage and Enhanced Cell Survival

NEIL1 is unique among the oxidatively damaged base repair-initiating DNA glycosylases in the human genome due to its S phase-specific activation and ability to excise substrate base lesions from single-stranded DNA. We recently characterized NEIL1’s specific binding to downstream canonical repair and non-canonical accessory proteins, all of which involve NEIL1’s disordered C-terminal segment as the common interaction domain (CID). This domain is dispensable for NEIL1’s base excision and abasic (AP) lyase activities, but is required for its interactions with other repair proteins. Here, we show that truncated NEIL1 lacking the CID is markedly deficient in initiating in vitro repair of 5-hydroxyuracil (an oxidative deamination product of C) in a plasmid substrate compared to the wild-type NEIL1, thus suggesting a critical role of CID in the coordination of overall repair. Furthermore, while NEIL1 downregulation significantly sensitized human embryonic kidney (HEK) 293 cells to reactive oxygen species (ROS), ectopic wild-type NEIL1, but not the truncated mutant, restored resistance to ROS. These results demonstrate that cell survival and NEIL1-dependent repair of oxidative DNA base damage require interactions among repair proteins, which could be explored as a cancer therapeutic target in order to increase the efficiency of chemo/radiation treatment.
Sensors and Control Concept of Walking “Johnnie”

One key problem to achieve a dynamically stable walking motion with biped robots is to measure and control the actual state of the robot with respect to its environment. Dynamically stable walking on unstructured terrain and fast walking can only be achieved with an orientation sensor. The control system of the biped robot “Johnnie” is designed such that the orientation of the upper body is controlled throughout all phases of the gait pattern. Furthermore, a sophisticated measurement and control of the foot torques has been implemented. In this way, the interaction forces and torques between robot and environment are controlled and tilting of the foot is avoided.
High‐risk human papillomavirus infection associated with telomere elongation in patients with esophageal squamous cell carcinoma with poor prognosis

Telomere maintenance is crucial in carcinogenesis and tumor progression. The results of a previous study from the authors indicated that infection with high‐risk human papillomavirus (HR‐HPV) types 16, 18, and 58 was a risk factor for esophageal squamous cell carcinoma (ESCC) in the Shantou region of China. In the current study, the authors explored the association between HR‐HPV infection, telomere length (TL), and DNA methylation and their significance in the prognosis of patients with ESCC.
“Love Sport, Even When It Breaks Your Heart Again”: Ritualizing Consumerism in Sports on Weibo

Social media have changed the way that social actors participate in sports events. “Prosumers” are able to directly offer different interpretations without journalists’ mediation when a social issue arises. However, social media do not fundamentally change the significance of cultural narratives in communication. This study focuses on discussions initiated by a commercial feed on a Chinese microblogging site during the 2012 London Olympic Games. Qualitative textual analysis was conducted. The study found that enduring cultural narratives create the predrafts of social-media communication; the instantaneity of microblogging referred to not simply its physical appearance but also the meaning of that appearance. In addition, social-media texts illustrate a society’s ongoing stories. Going beyond the limitations of previous control-vs.-freedom paradigms, this study explores a Chinese consumer society that is more dynamic and complex than previous studies would suggest.
The Zinc Finger Protein Zfr1p Is Localized Specifically to Conjugation Junction and Required for Sexual Development in Tetrahymena thermophila

Conjugation in Tetrahymena thermophila involves a developmental program consisting of three prezygotic nuclear divisions, pronuclear exchange and fusion, and postzygotic and exconjugant stages. The conjugation junction structure appears during the initiation of conjugation development, and disappears during the exconjugant stage. Many structural and functional proteins are involved in the establishment and maintenance of the junction structure in T. thermophila. In the present study, a zinc finger protein-encoding gene ZFR1 was found to be expressed specifically during conjugation and to localize specifically to the conjugation junction region. Truncated Zfr1p localized at the plasma membrane in ordered arrays and decorated Golgi apparatus located adjacent to basal body. The N-terminal zinc finger and C-terminal hydrophobic domains of Zfr1p were found to be required for its specific conjugation junction localization. Conjugation development of ZFR1 somatic knockout cells was aborted at the pronuclear exchange and fusion conjugation stages. Furthermore, Zfr1p was found to be important for conjugation junction stability during the prezygotic nuclear division stage. Taken together, our data reveal that Zfr1p is required for the stability and integrity of the conjugation junction structure and essential for the sexual life cycle of the Tetrahymena cell.
A Holistic Perspective on the Performance Implications of Strategic Alignment in Knowledge Management

Recently, the importance of the information technology (IT) for effective knowledge management (KM) activities has been noted. The match of IT and KM is an important concern for executives. However, their efforts do not always yield positive organizational outcome since enough exceptions indicate that knowledge management strategy and human resource management (HRM) strategy are interdependent that must be integrated with IT as a whole. Consequently, a linkage of effective IT strategy and KM strategy that are consistent with HRM strategy is the key to reduced costs, which in turn, will achieve a higher performance. Drawing on the concept of strategic alignment, this study proposes a KM strategic alignment model within which KM strategy, IT strategy, and HRM strategy, coexist. Survey research method is employed in this study. Empirical data for hypotheses testing are collected from top-ranking companies in Taiwan, yielding 161 valid samples. Performance implications of strategic alignment are examined using covariation and profile deviation approaches. The results suggest that strategic alignment among these three strategies contributes to business performance. Based on the research results, meaningful findings and conclusions are described and suggestions for future research are proposed.
Analysis and Representation of Computer Vision Systems by the Object-Process Methodology

Computer vision involves a host of problems, algorithms and techniques dealing with all aspects of capturing scenes and converting them into meaningful interpretations. A computer vision system may include a pattern recognition subsystem and be itself embedded within a more complex system. Machine vision systems feature a combination of complexity on one hand and a balance between structure and behavior on the other hand. Analysis and design of computer vision svstems calls therefore for a metKodology that represents &ually well structure and behavior within a unified frame of - --~ reference and has adequate tools for complexity management. This paper discusses the object-process analysis (OPA) as an approach to tackle this task. Following the introduction of the basic OPA principles, we use the Image Understanding Environment (IUE) Project documentation to demonstrate the principles, use and the benefits of the methodology. The result is a series of consistent, inter-related object-process diagrams that gradually expose the details of the system. Complexity is managed through visibility control, which is obtained by a host of options for scaling object process diagrams. The ease of application of object-process analysis to the case in point suggests that it can be successfully applied to analyze, understand and wmmunicate complex software systems such as the IUE Project.
Anxiety and Depression Scale. Comparison of the General Health Questionnaire and the Hospital

References http://bjp.rcpsych. org/content/157/6/860#BIBL This article cites 0 articles, 0 of which you can access for free at: permissions Reprints/ permissions@rcpsych.ac. uk to To obtain reprints or permission to reproduce material from this paper, please write to this article at You can respond http://bjp.rcpsych. org/cgi/eletter-submit/157/6/860 from Downloaded The Royal College of Psychiatrists Published by on January 13, 2012 http://bjp.rcpsych. org/
Transition of Young Children into the Elementary Education Mainstream

A major goal of early childhood special education (ECSE) programs is to promote the entry of young children with handicaps into kindergarten and the elementary school mainstream. The transition from ECSE to the kindergarten classroom and elementary school mainstream may present several challenges for the child, family, and professionals. A model for planning this transition and addressing the challenges is presented. The model, developed through Project TEEM, enables parents, ECSE, and elementary school program staff to collaboratively establish and implement procedures for planning transitions. The model insures that the procedures (a) address the strengths, needs, and characteristics of individual children, families, and school programs; (b) promote the implementation of best practices in transition planning; and (c) result in the successful transition of children and families into the elementary school mainstream.
Individual Spirituality at Work and Its Relationship with Job Satisfaction, Propensity to Leave and Job Commitment

Spirituality is a hot topic of research in recent times in management arena. Though the organizational researchers have intensely started exploring this area, the studies related to selling organizations are few, and fewer are the studies related to selling organizations with individual (sales professional) as the unit of theory. The present study explores the relationship between ‘individual spirituality at work’ and sales professionals’ ‘job satisfaction’, ‘propensity to leave’ and ‘job commitment’. This work focuses on sales professionals across various industries. A cross-sectional survey method is adopted. Correlation analysis is done to reveal the hypothesized relationships. The results reveal that sales professionals’ spirituality at work is positively related to job satisfaction and job commitment, and negatively related to propensity to leave. The results provide the relevance of spirituality at work to salespeople. The selling organizations can also utilize the information and promote the individual expression of spirituality at work.
Using the MAXNHANES Merged Data to Evaluate the Association of Obesity and Medicaid Costs

This brief presents the results of the first study conducted using the newly merged Medicaid Analytic eXtract (MAX) and National Health and Nutrition Examination Survey (NHANES) data. The study evaluated the association between Medicaid costs and obesity among adults in 1999â€“2004. Although the estimated costs were higher for obese adults than for non-obese adults, the combination of a small sample size for NHANES data, wide variation in costs among Medicaid enrollees, and the necessity of controlling for state variation yielded an unstable model with imprecisely estimated relationships. The results demonstrate the hazard of using a small national survey (NHANES) with a state-based data system (MAX) to perform cost analyses, particularly when the range of realistic costs is large.
Time trends in statin utilisation and coronary mortality in Western European countries

Objectives To determine whether there is a relation between statin utilisation and coronary heart disease (CHD) mortality in populations with different levels of coronary risk, and whether the relation changes over time. Design Ecological study using national databases of dispensed medicines and mortality rates. Setting Western European countries with similar public health systems. Main outcome measures Population CHD mortality rates (rate/100 000) as a proxy for population coronary risk level, and statin utilisation expressed as Defined Daily Dose per one Thousand Inhabitants per Day (DDD/TID), in each country, for each year between 2000 and 2012. Spearman's correlation coefficients between CHD mortality and statin utilisation were calculated. Linear regression analysis was used to assess the relation between changes in CHD mortality and statin utilisation over the years. Results 12 countries were included in the study. There was a wide range of CHD mortality reduction between the years 2000 and 2012 (from 25.9% in Italy to 57.9% in Denmark) and statin utilisation increase (from 121% in Belgium to 1263% in Denmark). No statistically significant relations were found between CHD mortality rates and statin utilisation, nor between changes in CHD and changes in statin utilisation in the countries over the years 2000 and 2012. Conclusions Among the Western European countries studied, the large increase in statin utilisation between 2000 and 2012 was not associated with CHD mortality, nor with its rate of change over the years. Factors different from the individual coronary risk, such as population ageing, health authority programmes, guidelines, media attention and pharmaceutical industry marketing, may have influenced the large increase in statin utilisation. These need to be re-examined with a greater emphasis on prevention strategies.
Accurate Characterization of Shielding Effectiveness of Metallic Enclosures With Thin Wires and Thin Slots

In many electrical and electronic systems, metallic enclosures are used to provide electromagnetic shielding. These enclosures normally contain thin wires, thin slots, and frequency-selective slots (FSS) that degrade the shielding effects. In this paper, integrated FDTD formulations are developed that can model both subcellular thin slots and thin wires simultaneously. The formulations are shown to be capable of accurately predicting shielding effectiveness and inner field distributions of a metallic enclosure in both the frequency- and time-domains when subject to a high-power electromagnetic pulse.
Advanced synchronisation and decoding in RFID reader receivers

This paper focuses on one of the major challenges in RFID reader receivers, namely the data synchronisation and decoding at the RFID reader. According to the most widely used RFID standards, the data rate in RFID tag to reader communications is subject to variations within more than one decade, and may deviate from its nominal frequency up to 22%. This results in strong difficulties in synchronising and decoding this data at the receiver of the RFID reader. In order to achieve synchronisation and decoding, a sophisticated algorithm based on correlations is presented. The algorithm is optimised in terms of resource consumption to be processed on an FPGA or ASIC. Implementation details are presented as well as measurements, showing the performance of the receiver.
Discriminative components of data

A simple probabilistic model is introduced to generalize classical linear discriminant analysis (LDA) in finding components that are informative of or relevant for data classes. The components maximize the predictability of the class distribution which is asymptotically equivalent to 1) maximizing mutual information with the classes, and 2) finding principal components in the so-called learning or Fisher metrics. The Fisher metric measures only distances that are relevant to the classes, that is, distances that cause changes in the class distribution. The components have applications in data exploration, visualization, and dimensionality reduction. In empirical experiments, the method outperformed, in addition to more classical methods, a Renyi entropy-based alternative while having essentially equivalent computational cost.
Distinct Effects of Ketone Bodies on Down-Regulation of Cell Surface Insulin Receptor and Insulin Receptor Substrate-1 Phosphorylation in Adrenal Chromaffin Cells

Treatment (≧24 h) of cultured bovine adrenal chromaffin cells with ketoacidosis-related concentrations (≧3 mM) of acetoacetate (but not β-hydroxybutyrate, acetone, and acidic medium) caused a time- and concentration-dependent reduction of cell surface125I-insulin binding by ∼38%, with no change in theK d value. The reduction of125I-insulin binding returned to control nontreated level at 24 h after the washout of acetoacetate-treated cells. Acetoacetate did not increase the internalization rate of cell surface insulin receptor (IR), as measured in the presence of brefeldin A, an inhibitor of cell surface vesicular exit from thetrans-Golgi network. Acetoacetate (10 mM for 24 h) lowered cellular levels of the immunoreactive IR precursor molecule (∼190 kDa) and IR by 22 and 28%, respectively. Acetoacetate decreased IR mRNA levels by ∼23% as early as 6 h, producing their maximum plateau reduction at 12 and 24 h. The half-life of IR mRNA was shortened by acetoacetate from 13.6 to 9.5 h. Immunoprecipitation followed by immunoblot analysis revealed that insulin-induced (100 nM for 10 min) tyrosine-phosphorylation of insulin receptor substrate-1 (IRS-1) was attenuated by 56% in acetoacetate-treated cells, with no change in IRS-1 level. These results suggest that chronic treatment with acetoacetate selectively down-regulated the density of cell surface functional IR via lowering IR mRNA levels and IR synthesis, thereby retarding insulin-induced activation of IRS-1.
The Cross Entropy Method for Fast Policy Search

We present a learning framework for Markovian decision processes that is based on optimization in the policy space. Instead of using relatively slow gradient-based optimization algorithms, we use the fast Cross Entropy method. The suggested framework is described for several reward criteria and its effectiveness is demonstrated for a grid world navigation task and for an inventory control problem.
Simple and Practical FPGA Implementation of Space Vector Modulation Based on Geometrical Considerations

This paper presents a practical implementation on a field programmable gate array (FPGA) of a space vector modulator (SVM) for a three-phase voltage inverter. These schemes can be carried out using analog circuits or digital circuits, such as DSPs and microcontrollers. A more practical and faster solution is the use of FPGAs. The proposed method consists on the on-line calculation of alpha-beta vectors without trigonometric functions based on geometrical considerations. The switching pattern generation and sector identification made by the space vector modulation technique, delivers the control signals to the insulated gate bipolar transistors (IGBT) based power inverter. This implementation is very flexible, has low-cost and also very compact. If the computational load increases the cost not increases. Simulation results are presented to validate the theoretical observations
Social Inclusivity VS Analytical Acuity? A Qualitative Study of UK Researchers Regarding the Inclusion of Minority Ethnic Groups in Biobanks

This paper examines how the drive to include minority ethnic groups in biomedical research raises challenging questions for the governance of some biobanks. Using findings from a qualitative study with researchers working at 10 UK biobanks that have been designed to explore common complex diseases, our study highlights the potential discordance between the twin imperatives of ‘social inclusivity’ and ‘analytical acuity’. While the researchers interviewed were keen to include minority ethnic groups in their research, they were also concerned that this could have deleterious effects on the precision of their analyses. In our discussion of these findings we show that there remains considerable debate as to the impact of including participants from minority ethnic groups on analytical acuity. Nevertheless, a principle of justice requires that potential participants from all ethnic groups should be given the opportunity to participate in and benefit from biomedical research, and UK law requires public bodies (including research councils) to demonstrate that there is no unintentional or unjustifiable ‘racial’ discrimination in their activities. Researchers' concerns about analytical acuity could result in calls for study designs that examine every ‘different’ ethnic group, which would have consequences for the governance of some biobank studies and for efforts to challenge the discredited yet resilient idea that differences between ethnic groups are innate, essential and immutable.
How can we deﬁne intrinsic motivation

Intrinsic motivation is a crucial mechanism for open-ended cognitive development since it is the driver of spontaneous exploration and curiosity. Yet, it has so far only been conceptualized in ad hoc manners in the epigenetic robotics com- munity. After reviewing diﬀerent approaches to intrinsic motivation in psychology, this pa- per presents a uniﬁed deﬁnition of intrinsic mo- tivation, based on the theory of Daniel Berlyne. Based on this deﬁnition, we propose a landscape of types of computational approaches, making it possible to position existing and future models rel- ative to each other, and we show that important approaches are still to be explored.