Miracle-dz/UniFAR-FTUs huggingface dataset:
Biologics: Targets and Therapy Dovepress Eag1 Channels as Potential Early-stage Biomarkers of Hepatocellular Carcinoma

you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms Abstract: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. HCC is usually asymptomatic at potential curative stages, and it has very poor prognosis if detected later. Thus, the identification of early biomarkers and novel therapies is essential to improve HCC patient survival. Ion channels have been proposed as potential tumor markers and therapeutic targets for several cancers including HCC. Especially, the ether à-go-go-1 (Eag1) voltage-gated potassium channel has been suggested as an early marker for HCC. Eag1 is overexpressed during HCC development from the cirrhotic and the preneoplastic lesions preceding HCC in a rat model. The channel is also overexpressed in human HCC. Astemizole has gained great interest as a potential anticancer drug because it targets several proteins involved in cancer including Eag1. Actually, in vivo studies have shown that astemizole may have clinical utility for HCC prevention and treatment. Here, we will review first some general aspects of HCC including the current biomarkers and therapies, and then we will focus on Eag1 channels as promising tools in the early diagnosis of HCC.
Orthogeriatric care: improving patient outcomes

Hip fractures are a very serious socio-economic problem in western countries. Since the 1950s, orthogeriatric units have introduced improvements in the care of geriatric patients admitted to hospital because of hip fractures. During this period, these units have reduced mean hospital stays, number of complications, and both in-hospital mortality and mortality over the middle term after hospital discharge, along with improvements in the quality of care and a reduction in costs. Likewise, a recent clinical trial has reported greater functional gains among the affected patients. Studies in this field have identified the prognostic factors present upon admission or manifesting themselves during admission and that increase the risk of patient mortality or disability. In addition, improved care afforded by orthogeriatric units has proved to reduce costs. Nevertheless, a number of management issues remain to be clarified, such as the optimum anesthetic, analgesic, and thromboprophylactic protocols; the type of diagnostic and therapeutic approach best suited to patients with cognitive problems; or the efficiency of the programs used in convalescence units or in home rehabilitation care. Randomized clinical trials are needed to consolidate the evidence in this regard.
Differential effects of hunger and satiety on insular cortex and hypothalamic functional connectivity

The insula cortex and hypothalamus are implicated in eating behaviour, and contain receptor sites for peptides and hormones controlling energy balance. The insula encompasses multi‐functional subregions, which display differential anatomical and functional connectivities with the rest of the brain. This study aimed to analyse the effect of fasting and satiation on the functional connectivity profiles of left and right anterior, middle, and posterior insula, and left and right hypothalamus. It was hypothesized that the profiles would be altered alongside changes in homeostatic energy balance. Nineteen healthy participants underwent two 7‐min resting state functional magnetic resonance imaging scans, one when fasted and one when satiated. Functional connectivity between the left posterior insula and cerebellum/superior frontal gyrus, and between left hypothalamus and inferior frontal gyrus was stronger during fasting. Functional connectivity between the right middle insula and default mode structures (left and right posterior parietal cortex, cingulate cortex), and between right hypothalamus and superior parietal cortex was stronger during satiation. Differences in blood glucose levels between the scans accounted for several of the altered functional connectivities. The insula and hypothalamus appear to form a homeostatic energy balance network related to cognitive control of eating; prompting eating and preventing overeating when energy is depleted, and ending feeding or transferring attention away from food upon satiation. This study provides evidence of a lateralized dissociation of neural responses to energy modulations.
Bondable lingual spur therapy to treat anterior open bite

BONDABLE LINGUAL SPUR THERAPY TO TREAT ANTERIOR OPEN BITE Elissa Joy McRae, DDS Marquette University, 2010 The purpose of this study was to evaluate the effect of bondable lingual tongue spurs (BLTS; Tongue Tamers, Ortho Technology, Tampa, FL) on measures of overbite and incisor position in a sample of anterior open bite subjects who had either a digitsucking habit or an anterior tongue posture problem. Patient acceptance of the spurs was also evaluated. BLTS were placed on all maxillary and mandibular incisors of 12 subjects (mean age 13.9 years) with anterior open bite. Dental casts and lateral cephalometric radiographs were taken pre-treatment (T1) and after 6 months of lingual spur treatment alone (T2). Overbite and overjet of the anterior teeth were measured and compared on preand post-treatment study models. Differences in the cephalometric analyses between T1 and T2 were also assessed. Questionnaires were completed to evaluate the subjects’ acceptance of the spurs. A statistically significant increase in overbite was found on all 6 anterior teeth measured on the study models. This observation was corroborated by the statistically significant increase in anterior overbite (1.38 ± 0.89mm; P<0.001) and uprighting of the upper and lower incisors observed on cephalometric radiographs. Overjet was not affected by the treatment. BLTS were well tolerated by the subjects. Eleven of 12 subjects adjusted to the spurs in 2 weeks or less. Bondable lingual tongue spur treatment, in subjects with either digit-sucking habits or tongue posture problems, resulted in a significant reduction of anterior open bite and incisor proclination by successfully keeping pressure away from the anterior teeth. The spurs were placed in one appointment were well tolerated by patients.
Faceted-nonfaceted growth transition and 3-D morphological evolution of primary Al_6Mn microcrystals in directionally solidified Al-3 at.% Mn alloy

A comprehensive understanding of the growth pattern of intermetallic compounds (IMCs) during solidification is critical to both the crystal-growth theory and its property optimization. In this article, growth pattern and three-dimensional (3D) morphology of primary Al_6Mn IMC were investigated in directionally solidified Al-3 at. % Mn alloy at a wide range of growth rates. A transition from faceted (<60 µm/s) to nonfaceted growth (>100 µm/s) was observed with increasing growth rates. Correspondingly, 3D morphologies of primary Al_6Mn change from a solid polyhedron to a hollow structure, and then to a dendrite. This kind of change is associated with the competitive growths of different crystal planes determined by the crystallographic anisotropy and growth kinetics of Al_6Mn. A growth model based on atomic cluster attachment is proposed to reveal the growth transition, and a growth-rate ratio between different crystal planes is used to appropriately reveal the formation mechanism of different morphologies at low rates.
A detailed characterization of congenital defects and mortality following moderate X-ray doses during neurulation.

BACKGROUND Both epidemiological and animal studies have previously indicated a link between in utero radiation exposure and birth defects such as microphthalmos, anophthalmos, and exencephaly. However, detailed knowledge on embryonic radiosensitivity during different stages of neurulation is limited, especially in terms of neural tube defect and eye defect development. METHODS To assess the most radiosensitive stage during neurulation, pregnant C57BL6/J mice were X-irradiated (0.5 Gy or 1.0 Gy) at embryonic days (E)7, E7.5, E8, E8.5, or E9. Next, the fetuses were scored macroscopically for various defects and prenatal resorptions/deaths were counted. In addition, cranial skeletal development was ascertained using the alcian-alizarin method. Furthermore, postnatal/young adult survival was followed until 5 weeks (W5) of age, after X-irradiation at E7.5 (0.1 Gy, 0.5 Gy, or 1.0 Gy). In addition, body and brain weights were registered at adult age (W10) following X-ray exposure at E7.5 (0.1 Gy, 0.5 Gy). RESULTS Several malformations, including microphthalmos and exencephaly, were most evident after irradiation at E7.5, with significance starting respectively at 0.5 Gy and 1.0 Gy. Prenatal mortality and weight were significantly affected in all irradiated groups. Long-term follow-up of E7.5 irradiated animals revealed a reduction in survival at 5 weeks of age after high dose exposure (1.0 Gy), while lower doses (0.5 Gy, 0.1 Gy) did not affect brain and body weight at postnatal week 10. CONCLUSIONS With this study, we gained more insight in radiosensitivity throughout neurulation, and offered a better defined model to further study radiation-induced malformations and the underlying mechanisms.
When Does a Refactoring Induce Bugs? An Empirical Study

Refactorings are - as defined by Fowler - behavior preserving source code transformations. Their main purpose is to improve maintainability or comprehensibility, or also reduce the code footprint if needed. In principle, refactorings are defined as simple operations so that are "unlikely to go wrong" and introduce faults. In practice, refactoring activities could have their risks, as other changes. This paper reports an empirical study carried out on three Java software systems, namely Apache Ant, Xerces, and Ar-go UML, aimed at investigating to what extent refactoring activities induce faults. Specifically, we automatically detect (and then manually validate) 15,008 refactoring operations (of 52 different kinds) using an existing tool (Ref-Finder). Then, we use the SZZ algorithm to determine whether it is likely that refactorings induced a fault. Results indicate that, while some kinds of refactorings are unlikely to be harmful, others, such as refactorings involving hierarchies (e.g., pull up method), tend to induce faults very frequently. This suggests more accurate code inspection or testing activities when such specific refactorings are performed.
Patient dosimetry for 90Y selective internal radiation treatment based on 90Y PET imaging

Until recently, the radiation dose to patients undergoing the 90Y selective internal radiation treatment (SIRT) procedure is determined by applying the partition model to 99mTc MAA pretreatment scan. There can be great uncertainty in radiation dose calculated from this approach and we presented a method to compute the 3D dose distributions resulting from 90Y SIRT based on 90Y positron emission tomography (PET) imaging. Five 90Y SIRT treatments were retrospectively analyzed. After 90Y SIRT, patients had 90Y PET/CT imaging within 6 hours of the procedure. To obtain the 3D dose distribution of the patients, their respective 90Y PET images were convolved with a Monte Carlo generated voxel dose kernel. The sensitivity of the PET/CT scanner for 90Y was determined through phantom studies. The 3D dose distributions were then presented in DICOM RT dose format. By applying the linear quadratic model to the dose data, we derived the biologically effective dose and dose equivalent to 2 Gy/fraction delivery, taking into account the spatial and temporal dose rate variations specific for SIRT. Based on this data, we intend to infer tumor control probability and risk of radiation induced liver injury from SIRT by comparison with established dose limits. For the five cases, the mean dose to target ranged from 51.7 ± 28.6Gy to 163 ± 53.7 Gy. Due to the inhomogeneous nature of the dose distribution, the GTVs were not covered adequately, leading to very low values of tumor control probability. The mean dose to the normal liver ranged from 21.4 ± 30.7 to 36.7 ± 25.9 Gy. According to QUANTEC recommendation, a patient with primary liver cancer and a patient with metastatic liver cancer has more than 5% risk of radiotherapy‐induced liver disease (RILD). PACS number: 87.53. Bn
Effective algorithms for cache-level compression

Compression at the cache level has the potential to increase microprocessor performance by decreasing the cache miss rate and increasing the e ective bandwidth by transmitting compressed data This paper presents four compression al gorithms that would be suitable for use in a compressed cache architecture and shows the results of using them to compress SPEC benchmarks These algorithms exhibit a to improvement in compression ratio over an algorithm known to be e ective for cache compression
Reno-Protective Efficiency of Coenzyme Q 10 on Adriamycin-Induced Nephrotoxicity in Rats

The nephroprotective effect of coenzyme Q10 (CoQ10) was investigated in rats with acute renal injury induced by the anthracycline antibiotic doxorubicin (Adriamycin). A total of sixty rats were allocated into four groups. Group I: the rats were given only saline throughout all thirty days experimental period (control group). Group II (CoQ10 group): the rats were daily injected intraperitoneally (i.p) with 50mg CoQ10/kg body weight all through the experimental period. Group III (Adriamycin "Acute renal failure" group): The rats were bi-daily injected (i.p) as a cumulative dose of adriamycin (10mg/Kg b.w.), which divided into 6 equal injections over a period of two weeks. Group IV (Therapeutic group): the rats were injected with adriamycin to induce acute renal failure and then treated intraperitoneally with 50mg of CoQ10/kg b.w. for 30 days. In regard to the induction of acute renal failure in rats by adriamycin administration, the obtained results showed a significant elevation in the serum levels of urea and creatinine with disturbance in the serum electrolytes (sodium, potassium, calcium and inorganic phosphorus) levels. Also, a significant increment in both parathyroid hormone (PTH) and ß2-microglobulin (ß2-MG) levels was recorded in adriamycin rats group. A considerable disturbance in the autoimmune system was pronounced in adriamycin rats group represented by depletion in the activities of superoxide dismutase (SOD) and catalase (CAT) and the level of glutathione (GSH) with elevation in the concentration of thiobarbituric acid reactive substances (TBARS) as lipid peroxidation in the kidney tissues. The results of the current study indicated that CoQ10 effectively protected the kidney tissue against adriamycin induced acute nephrotoxicity in rats. The antioxidant and anti-inflammatory activities can be considered the main factors responsible for the nephroprotective effect of CoQ10. Therefore, CoQ10 represents a potential candidate to prevent renal injury and dysfunction which is a major and dose-limiting problem during adriamycin therapy.
Irisin in Blood Increases Transiently after Single Sessions of Intense Endurance Exercise and Heavy Strength Training

Purpose Irisin is a recently identified exercise-induced hormone that increases energy expenditure, at least in rodents. The main purpose of this study was to test the hypothesis that Irisin increases acutely in blood after singular sessions of intense endurance exercise (END) and heavy strength training (STR). Secondary, we wanted to explore the relationship between body composition and exercise-induced effects on irisin, and the effect of END and STR on muscular expression of the irisin gene FNDC5. Methods Nine moderately trained healthy subjects performed three test days using a randomized and standardized crossover design: one day with 60 minutes of END, one day with 60 minutes of STR, and one day without exercise (CON). Venous blood was sampled over a period of 24h on the exercise days. Results Both END and STR led to transient increases in irisin concentrations in blood, peaking immediately after END and one hour after STR, before gradually returning to baseline. Irisin responses to STR, but not END, showed a consistently strong negative correlation with proportions of lean body mass. Neither END nor STR affected expression of FNDC5, measured 4h after training sessions, though both protocols led to pronounced increases in PGC-1α expression, which is involved in transcriptional control of FNDC5. Conclusion The results strongly suggest that single sessions of intense endurance exercise and heavy strength training lead to transient increases in irisin concentrations in blood. This was not accompanied by increased FNDC5 expression, measured 4h post-exercise. The results suggest that irisin responses to resistance exercise are higher in individuals with lower proportions of lean body mass.
Phylogenetics links monster larva to deep-sea shrimp

Mid-water plankton collections commonly include bizarre and mysterious developmental stages that differ conspicuously from their adult counterparts in morphology and habitat. Unaware of the existence of planktonic larval stages, early zoologists often misidentified these unique morphologies as independent adult lineages. Many such mistakes have since been corrected by collecting larvae, raising them in the lab, and identifying the adult forms. However, challenges arise when the larva is remarkably rare in nature and relatively inaccessible due to its changing habitats over the course of ontogeny. The mid-water marine species Cerataspis monstrosa (Gray 1828) is an armored crustacean larva whose adult identity has remained a mystery for over 180 years. Our phylogenetic analyses, based in part on recent collections from the Gulf of Mexico, provide definitive evidence that the rare, yet broadly distributed larva, C. monstrosa, is an early developmental stage of the globally distributed deepwater aristeid shrimp, Plesiopenaeus armatus. Divergence estimates and phylogenetic relationships across five genes confirm the larva and adult are the same species. Our work demonstrates the diagnostic power of molecular systematics in instances where larval rearing seldom succeeds and morphology and habitat are not indicative of identity. Larval–adult linkages not only aid in our understanding of biodiversity, they provide insights into the life history, distribution, and ecology of an organism.
Automatic detection of small lung nodules on CT utilizing a local density maximum algorithm

Increasingly, computed tomography (CT) offers higher resolution and faster acquisition times. This has resulted in the opportunity to detect small lung nodules, which may represent lung cancers at earlier and potentially more curable stages. However, in the current clinical practice, hundreds of such thin‐sectional CT images are generated for each patient and are evaluated by a radiologist in the traditional sense of looking at each image in the axial mode. This results in the potential to miss small nodules and thus potentially miss a cancer. In this paper, we present a computerized method for automated identification of small lung nodules on multislice CT (MSCT) images. The method consists of three steps: (i) separation of the lungs from the other anatomic structures, (ii) detection of nodule candidates in the extracted lungs, and (iii) reduction of false‐positives among the detected nodule candidates. A three‐dimensional lung mask can be extracted by analyzing density histogram of volumetric chest images followed by a morphological operation. Higher density structures including nodules scattered throughout the lungs can be identified by using a local density maximum algorithm. Information about nodules such as size and compact shape are then incorporated into the algorithm to reduce the detected nodule candidates which are not likely to be nodules. The method was applied to the detection of computer simulated small lung nodules (2 to 7 mm in diameter) and achieved a sensitivity of 84.2% with, on average, five false‐positive results per scan. The preliminary results demonstrate the potential of this technique for assisting the detection of small nodules from chest MSCT images. PACS number(s): 87.57. –s, 87.90. +y
Personalized and Location-based Mobile Tourism Services

Mobile users such as tourists require mobile services. Handheld devices promise access to a range of travel-related services while on tour. A number of usability issues, however, still ask for intelligent new solutions. Issues are, for example, the limited capacity of handheld devices, user interaction via small screens, mediation of heterogeneous services, as well as other issues of wireless access to internet-based services. Key features of the CRUMPET system are personalisation, location awareness, interaction facilitation and service mediation. Its realisation as a multi-agent architecture opens up additional prospects.
IMG: the integrated microbial genomes database and comparative analysis system

The Integrated Microbial Genomes (IMG) system serves as a community resource for comparative analysis of publicly available genomes in a comprehensive integrated context. IMG integrates publicly available draft and complete genomes from all three domains of life with a large number of plasmids and viruses. IMG provides tools and viewers for analyzing and reviewing the annotations of genes and genomes in a comparative context. IMG's data content and analytical capabilities have been continuously extended through regular updates since its first release in March 2005. IMG is available at http://img.jgi. doe.gov. Companion IMG systems provide support for expert review of genome annotations (IMG/ER: http://img.jgi.doe.gov/er), teaching courses and training in microbial genome analysis (IMG/EDU: http://img.jgi.doe.gov/edu) and analysis of genomes related to the Human Microbiome Project (IMG/HMP: http://www.hmpdacc-resources.org/img_hmp).
Unsupervised Segmentation of 5D Hyperpolarized Carbon-13 MRI Data Using a Fuzzy Markov Random Field Model

Hyperpolarized MRI with 13C-labelled compounds is an emerging clinical technique allowing in vivo metabolic processes to be characterized non-invasively. Accurate quantification of 13C data, both for clinical and research purposes, typically relies on the use of region-of-interest analysis to detect and compare regions of altered metabolism. However, it is not clear how this should be determined from the five-dimensional data produced and most standard methodologies are unable to exploit the multidimensional nature of the data. Here we propose a solution to the novel problem of 13C image segmentation using a hybrid Markov random field model with continuous fuzzy logic. The algorithm fully utilizes the multi-dimensional data format in order to classify each voxel into one of six distinct classes based on its metabolic characteristics. Bayesian priors fully incorporate spatial, temporal and ratiometric contextual information whilst image contrast from multiple spectral dimensions are considered concurrently by using an analogy from color image segmentation. Performance of the algorithm is demonstrated on in silico data, where the superiority of the approach over a reference thresholding method is consistently observed. Application to in vivo animal data from a pre-clinical subcutaneous tumor model illustrates the ability of the MRF algorithm to successfully detect tumor location whilst avoiding image artifacts. This work has the potential to assist the analysis of human hyperpolarized 13C data in the future.