Miracle-dz/UniFAR-FTUs huggingface dataset:
Genome-wide transcriptional profiling identifies potential signatures in discriminating active tuberculosis from latent infection

To better understand the host immune response involved in the progression from latent tuberculosis infection (LTBI) to active tuberculosis (TB) and identify the potential signatures for discriminating TB from LTBI, we performed a genome-wide transcriptional profile of Mycobacterium tuberculosis (M.TB)–specific antigens-stimulated peripheral blood mononuclear cells (PBMCs) from patients with TB, LTBI individuals and healthy controls (HCs). A total of 209 and 234 differentially expressed genes were detected in TB vs. LTBI and TB vs. HCs, respectively. Nineteen differentially expressed genes with top fold change between TB and the other 2 groups were validated using quantitative real-time PCR (qPCR), and showed 94.7% consistent expression pattern with microarray test. Six genes were selected for further validation in an independent sample set of 230 samples. Expression of the resistin (RETN) and kallikrein 1 (KLK1) genes showed the greatest difference between the TB and LTBI or HC groups (P < 0.0001). Receiver operating characteristic curve (ROC) analysis showed that the areas under the curve (AUC) for RETN and KLK1 were 0.844 (0.783–0.904) and 0.833 (0.769–0.897), respectively, when discriminating TB from LTBI. The combination of these two genes achieved the best discriminative capacity [AUC = 0.916 (0.872–0.961)], with a sensitivity of 71.2% (58.7%–81.7%) and a specificity of 93.6% (85.7%–97.9%). Our results provide a new potentially diagnostic signature for discriminating TB and LTBI and have important implications for better understanding the pathogenesis involved in the transition from latent infection to TB activation.
Anodyne Therapy for Recalcitrant Diabetic Foot Ulcers: A Report of Four Cases

Four patients with diabetic foot ulcers that failed to heal after one month of treatment underwent anodyne therapy. Each therapy session lasted half an hour and was conducted 3 times a week for patients at home or daily for patients in hospital, for one to 2 months. The wound sizes and depths were graded according to the Wagner classification. Pictures were taken to evaluate the effects of anodyne therapy. All 4 patients had good healing of their foot ulcers. Anodyne therapy augments the effects of conservative treatment. Proper wound care and appropriate antibiotic coverage remain the basis of treatment.
ANTIBACTERIAL ACTIVITY TEST OF SOUTH SULAWESI PROPOLIS EXTRACT AGAINST STREPTOCOCCUS MUTANS

Oral infection such as tooth caries and periodontal desease are the most commond bacterial infection in human. The main cause of periodontal disease is microorganisms that colonize and attached to the tooth surface around the gingival margin. Streptococcus mutans is the first bacteria that forms colonies and become the initiator of the other bacteriato do so. The left bacteria colonies may change to be plaque layer and causes an inflammatory reaction, may lead to tissue damage. Propolis is a natural substance, well known its benefits in dentistry. The type of propolis varies depending on the area or location and type of honey bees that produce it. Propolis is also expected to inhibit Streptococcus mutans that cause periodontal disease. : The aim of the study is determine the inhibition zone of propolis extract from South Sulawesi on Streptococcus mutans. Inhibition test was performed by the agar diffusion method using propolis test materials, provided in a concentrationof 2.5%, 5%, and 10% as well as negative control. Inhibition zone was measured after 24 hours incubation. Concentration has effect that causing significant difference in inhibition of the change in concentration of propolis (p<0.005). The use of different solvents in the extraction process also has an influence on the inhibition of propolis or there is a significant difference between the propolis extracted with hexane solution (fat-free propolis) and 70% of propolis solution (p<0.005). The interaction between the type of solvent with a concentration on its effect on the inhibition of propolis also showed a significant difference (p<0.005). South Sulawesi Propolis has inhibitory effect on Streptococcus mutans especially those was dissolved in70% ethanol solution and also influenced by the level of concentration.
ANALISIS PENERAPAN PERATURAN PEMERINTAH NO 46 TERHADAP KEPATUHAN WAJIB PAJAK PADA KANTOR PELAYANAN PAJAK PRATAMA DENPASAR TIMUR

Penerapan Peraturan Pemerintah Nomor 46 Tahun 2013 dimaksudkan untuk meningkatkan kepatuhan wajib pajak utamanya UMKM (Usaha Mikro Kecil Menengah) terhadap kewajiban perpajakan. Peningkatan kepatuhan wajib pajak berkorelasi positif terhadap peningkatan penerimaan pajak dan jumlah wajib pajak. Penelitian ini bertujuan untuk mengetahui dampak penerapan Peraturan Pemerintah Nomor 46 terhadap peningkatan penerimaan pajak di Kantor Pelayanan Pajak Pratama Denpasar Timur. Sedangkan manfaat penelitian ini diharapkan dapat digunakan sebagai dasar analisis terhadap dampak penerapan Peraturan Pemerintah Nomor 46 terhadap peningkatan penerimaan pajak. Teknik analisis yang digunakan adalah teknik kualitatif dengan menggambarkan secara sistimatis data-data yang telah dikumpulkan selanjutnya dianalisis dan diinterprestasikan. Berdasarkan deskripsi data dapat diketahui bahwa penerapan Peraturan Pemerintah Nomor 46 berdampak positif terhadap peningkatan penerimaan pajak penghasilan. Peningkatan paling signifikan terjadi pada sektor perdagangan dibandingkan dengan sektor jasa dan manufaktur. Hal ini terjadi karena wajib pajak sektor perdagangan diuntungkan dengan diterapkan peraturan pemerintah nomor 46 tersebut. Ilustrasi titik impas ( break even ) antara penerapan pajak penghasilan pasal 25 dengan peraturan pemerintah nomor 46 terjadi pada tingkat profit margin 8% (delapan persen). Artinya wajib pajak yang menetapkan profit margin diatas 8% akan diuntungkan dengan penerapan peraturan pemerintah nomor 46 ini, karena pajak terutang lebih kecil dibandingkan dengan tarif pasal 17 ayat (1). Sebaliknya wajib pajak yang profit marginnya di bawah 8% akan membayar pajak lebih besar dibandingkan dengan penerapan tariff pasal 17 ayat (1). Berdasarkan pembahasan dapat disarankan agar Direktorat Jenderal pajak dapat melakukan sosialisasi secara berkesinambungan kepada masyarakat terutama pengusaha kecil. Bagi wajib pajak dapat mempertimbangkan penetapan profit margin agar pemenuhan kewajiban perpajakannya bisa berjalan tanpa mengalami kerugian.
Continuous neuronal ensemble control of simulated arm reaching by a human with tetraplegia

Functional electrical stimulation (FES), the coordinated electrical activation of multiple muscles, has been used to restore arm and hand function in people with paralysis. User interfaces for such systems typically derive commands from mechanically unrelated parts of the body with retained volitional control, and are unnatural and unable to simultaneously command the various joints of the arm. Neural interface systems, based on spiking intracortical signals recorded from the arm area of motor cortex, have shown the ability to control computer cursors, robotic arms and individual muscles in intact non-human primates. Such neural interface systems may thus offer a more natural source of commands for restoring dexterous movements via FES. However, the ability to use decoded neural signals to control the complex mechanical dynamics of a reanimated human limb, rather than the kinematics of a computer mouse, has not been demonstrated. This study demonstrates the ability of an individual with long-standing tetraplegia to use cortical neuron recordings to command the real-time movements of a simulated dynamic arm. This virtual arm replicates the dynamics associated with arm mass and muscle contractile properties, as well as those of an FES feedback controller that converts user commands into the required muscle activation patterns. An individual with long-standing tetraplegia was thus able to control a virtual, two-joint, dynamic arm in real time using commands derived from an existing human intracortical interface technology. These results show the feasibility of combining such an intracortical interface with existing FES systems to provide a high-performance, natural system for restoring arm and hand function in individuals with extensive paralysis.
A simple current reference with low sensitivity to supply voltage and temperature

We propose a simple current reference circuit with low power supply voltage dependence and low temperature coefficient by combining output currents of conventional current mirror and Nagata current source. Detailed analysis and design procedure are presented. Preliminary test chip measurement results are also represented. Temperature dependence of the output current was compensated by synthesizing required temperature coefficient of a resistor from different types of on chip resistors. The output current indicated +200 ppm/deg temperature coefficient by circuit simulation, and is an order of improvement over without temperature compensation case. The proposed current reference circuit does not have positive feedback loop, thus, it is free from start-up problem unlike beta-multiplier. Design example indicated far better performance against power supply voltage change and temperature change than simple current mirror.
Preferences and Strategic Behavior in Public Goods Games

We analyze experimentally behavior in a finitely repeated public goods game. One of the main results of the literature is that contributions are initially high, and gradually decrease over time. Two explanations of this pattern have been developed: (i) the population is composed of free-riders, who never contribute, and conditional cooperators, who contribute if others do so as well; (ii) strategic players contribute to sustain mutually beneficial future cooperation, but reduce their contributions as the end of the game approaches. This paper contributes to bridging the gap between these views. We analyze preferences and strategic ability in one design by manipulating group composition to form homogeneous groups on both dimensions. Our results highlight the interaction between the two: groups that sustain high levels of cooperation are composed of members who share a common inclination toward cooperation and have the strategic abilities to recognize and reap the benefits of enduring cooperation.
Remyelination in multiple sclerosis

Stimulation of remyelination in multiple sclerosis lesions may be one possible therapeutic approach. However, since the pathology and pathogenesis of multiple sclerosis may be heterogeneous, it is important to analyze in what patients and at what stages of the disease such a therapy can be reasonable and feasible. Spontaneous remyelination is pronounced in some MS patients. The extent of remyelination correlates well with the presence of oligodendrocytes in the lesions. Yet, the source and origin of the remyelinating cells is still unclear. These may be derived from either undifferentiated progenitor cells or, in part from mature oligodendrocytes, that have escaped destruction during lesional activity. Complete remyelination of plaques is possible, leading to the formation of 'shadow plaques'. No reliable data are available at present on the frequency of remyelination in different forms of MS. However, most studies agree that remyelination is especially prominent at the early stages of the disease, whereas it is sparse after several years of disease duration. In addition, very little remyelination is found in cases of primary progressive MS.
Should the unemployed care for the elderly? The effect of subsidized occupational and further training in geriatric care

This study analyzes the effectiveness of subsidized training in elderly care professions for the unemployed in Germany. We find that shorter further training increases employment but hardly affects wages. Retraining, which entails a vocational degree as geriatric nurse, causes strong lock-in effects, but afterwards substantial positive wage and employment effects that exceed those of further training. Yet, large shares of the estimated employment effects are attributable to part-time employment.
Detection of digital forgeries using an image interpolation from digital images

Most of digital forgeries are created by Adobe Photoshopreg. Detecting digital forgery is one of most important emerging technology to solve digital forgery of digital images taken by a digital camera. This paper proposes a new method for detecting digital forgery using an image interpolation technique from digital images. When digital forgery is produced from digital images, it always includes the interpolated image between the images. Our approach is to compute the interpolated coefficient for the images using expectation-maximization (EM) algorithm. We demonstrate detecting the forgery images used to each filter for the tool of Adobe Photoshopreg and show a ratio of detecting the forgery images.
SELECTION DE VARIABLES POUR LA DISCRIMINATION EN GRANDE DIMENSION ET CLASSIFICATION DE DONNEES FONCTIONNELLES

Cette these s'inscrit dans le cadre de la statistique non parametrique et porte sur la classification et la discrimination en grande dimension, et plus particulierement sur la selection de variables. Une premiere partie traite de la selection de variables a travers cart, dans un cadre de regression et de classification binaire. La procedure exhaustive developpee s'appuie sur le principe de la selection de modele qui permet d'obtenir des inegalites " oracle " et de realiser une selection de variables par contraste penalise. Une seconde partie est motivee par un probleme industriel. Il s'agit de determiner parmi les signaux temporels, mesures au cours d'essais, ceux capables d'expliquer le ressenti de confort du conducteur, puis de definir les plages temporelles responsables de cette pertinence. La demarche adoptee s'articule autour du pretraitement des signaux, de la reduction de la dimension par compression dans une base d'ondelettes et de l'extraction de variables en melant cart a une strategie pas a pas. Une derniere partie aborde le theme de la classification de donnees fonctionnelles au moyen des k-plus proches voisins. La procedure consiste a appliquer les k-plus proches voisins sur les coordonnees de la projection des donnees fonctionnelles sur un espace fini-dimensionnel. Cette procedure implique de determiner simultanement la dimension de l'espace de projection et le nombre de voisins. La version usuelle des k-plus proches voisins et une version legerement penalisee sont considerees theoriquement. Un travail sur donnees reelles et simulees semble montrer que l'introduction d'un faible terme de penalite stabilise la selection en conservant de bonnes performances.
Ownership and utilization of insecticide-treated nets (ITNs) for malaria control in Harari National Regional State, Eastern Ethiopia

This erratum corrects "Ownership and utilization of insecticide-treated nets (ITNs) for malaria control in Harari National Regional State, Eastern Ethiopia". The Pan African Medical Journal. 2015; 21: 52. doi:10.11604/pamj.2015. 21.52. 5380
Intrathymic proliferation wave essential for Vα14+ natural killer T cell development depends on c-Myc

The molecular requirements for invariant Vα14-bearing natural killer T cells (iNKT) in the thymus are poorly understood. A minute population of ≈500 newly selected CD69+CD24+ stage 0 (ST0) iNKT cells gives rise to ≈100 times more CD44neg/loCD24− stage 1 (ST1) cells, which then generate similar frequencies of CD44hiCD24− stage 2 (ST2) and mature iNKT cells. Although the increased number of ST1 compared with ST0 cells indicates the initiation of a proliferation wave in the very early stages of iNKT cell development, details about the controlling mechanism are currently lacking. Here, we show that the transcription factor c-Myc is required for iNKT cell development. Conditional ablation of c-Myc in double-positive thymocytes specifically impacted iNKT but not conventional T cell development. Within the iNKT population, a progressive reduction of iNKT cells was observed starting at ST1 (≈50-fold) and ST2 (≈350-fold), with a complete lack of mature cells in thymus, spleen, and liver. ST0/ST1 c-Myc-deficient iNKT cells showed reduced proliferation. In contrast, annexin V staining did not reveal increased apoptosis, and transgenic overexpression of BCL-2 did not rescue iNKT cell development in c-Myc-deficient mice. Moreover, expression of known iNKT differentiation factors such as Plzf and Gata3 was not dramatically altered. These, findings provide compelling evidence that c-Myc mediates an intrathymic proliferation wave immediately after agonist selection of iNKT cells and illustrate the importance of this expansion for the generation of mature iNKT cells in vivo.
Metacognitive aspects influence subjective well‐being in parents of children with cancer

OBJECTIVE Research suggests that metacognitive beliefs may be involved in psychological distress and even in the pathogenesis of emotional disorders. The present research is a first attempt to investigate how certain metacognitive aspects operate as favorable or adverse factors influencing subjective wellbeing (SWB) in the parents of children with cancer. METHOD Thirty parents of children being treated for cancer completed questionnaires on their metacognitive beliefs (Metacognition Questionnaire), sensitivity to autobiographical memory, and self-reported measures of positive and negative affect (Positive and Negative Affect Schedule). Results in the study group were compared with those obtained from 36 control parents of children being treated for acute, not life-threatening illnesses (hospitalized control group) and from 30 control parents of healthy children (healthy control group). RESULTS Parents in both the study group and the hospitalized control group reported less SWB than the healthy control group. Most important, metacognitive aspects explained up to 77% of the variance in SWB in parents of children with cancer, as opposed to only 23% in hospitalized control group and 33% in the healthy control group. CONCLUSION Differentmetacognitive aspects have a crucial role—both negative and positive—inSWB of parents of children with cancer. It is suggested that the psychological support for parents copingwith a child suffering from oncological disease should assess such aspects and try to address them in clinical practice.
THE INFLUENCE OF PERCEIVED SERVICE PERFORMANCE ON GENERATION Z’S EWOM INTENTIONS IN THE FOOD SERVICE SECTOR

As “digital natives”, Generation Z consumers are extremely active on social media by sharing their opinions and experiences via several online platforms and mobile technologies. In the restaurant setting, electronic word of mouth (eWOM) information is quite resilient and influence consumers’ decisions as food services could not be evaluated before consumption. Nevertheless, previous studies examining the effect of Generation Z consumers’ perceptions about restaurant service experiences on their eWOM intentions have been fewer addressed. Consequently, the purpose of this study is to examine the relationship between Generation Z consumers’ perceived service performance of quick service restaurants (QSRs) which become popular among Thai teenagers and their eWOM intentions. Utilizing quantitative survey of 373 young consumers, the findings reported that perceived restaurant service performance positively related to eWOM intentions. In this regard, five components of restaurant service performance included food quality, personal interaction, perceived value, reliability, and physical environment. The findings contribute to the consumer behavior and digital marketing literature in that it provides a better understanding of the link between perceived service performance and electronic word-of-mouth (eWOM) in the restaurant setting. The framework could also facilitate future empirical studies in the hospitality industry. Additionally, the study could encourage food service marketers recognize the importance of eWOM and connect with young consumers to encourage positive eWOM communications while the costs of promotions are increasing.
A simple and efficient MPPT scheme for PV module using 2-Dimensional Lookup Table

An intermediate Maximum Power Point Tracking (MPPT) control algorithm is used to extract maximum power from the photovoltaic (PV) system. Among various traditional MPPT algorithms Perturb and Observe (P&O) is widely employed because of low cost and simple implementation. In P&O scheme, fixed step size perturbation consumes much time to track Maximum Power Point (MPP). Steady state power loss associated with P&O MPPT is high due to oscillations of operating point around MPP. To overcome the demerits associated with P&O scheme, this paper proposes a simple and efficient MPPT scheme using a 2-Dimensional Lookup Table. The results show that the proposed method has better steady state performance, accuracy and efficiency. Mathematical modeling of PV module, dc-dc converter and MPPT algorithms are given in detail.
A dual band polygon shaped CPW-fed planar monopole antenna with circular polarization and isolation enhancement for MIMO aplications

In this study, design and characteristics of a circularly-polarized (CP) CPW-fed monopole antenna is presented. This antenna operates in the ISM and WLAN bands. To improve isolation, a new configuration in microstrip antenna arrays is applied. The antenna has a compact aperture size of 20 × 20 mm2 which is simulated on FR4 substrate with dielectric constant of 4.4 and thickness of 1 mm. Results indicate that the return loss of this antenna is lower than -10 dB in 2.2-8.0 GHZ band. In addition, the antenna with a 3-dB axial ratio has the bandwidths of 36% and 17% for lower (2150-3100MHz) and upper (5150-6100 MHz) bands, respectively. The results of this investigation can be used to optimize the design of multiple-input-multiple-output (MIMO) communications.
Estimating Risk Difference in Multicenter Studies Under Baseline‐Risk Heterogeneity

Summary. In this paper, we consider the case of efficient estimation of the risk difference in a multicenter study allowing for baseline heterogeneity. We consider the optimally weighted estimator for the common risk difference and show that this estimator has considerable bias when the true weights (which are inversely proportional to the variances of the center‐specific risk difference estimates) are replaced by their sample estimates. In addition, we propose a new estimator for this situation of the Mantel‐Haeiiszel type that is unbiased and, in addition, has a smaller variance for small sample sizes within the study centers. Simulations illustrate these findings.
On the Value of Formal IT Education in Early IT Careers: A Multilevel Analysis

The IT labor market's increased appetite for IT workers who hold no formal IT education has raised concerns regarding the value of formal IT education. On that account, this study draws on human capital theory and examines whether formal IT education commands a premium over non-IT education in early IT careers. Using data from the U.S. NLSY97 cohort, we examine the wage value of formal IT education by employing a hierarchical linear modeling technique. We find that early career IT professionals (i