Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality by design approach for oral bioavailability enhancement of Irbesartan by self-nanoemulsifying tablets

Abstract The present investigation was aimed to develop self-nanoemulsifying tablets (SNETs) as novel nanosized solid oral dosage forms for Irbesartan (IRB). In the first part of the investigation, IRB-loaded self-nanoemulsifying drug delivery systems (SNEDDS) were developed using Capryol 90 – Cremophor RH40 – Transcutol P as three component (oil – surfactant – cosurfactant) SNEDDS system. On the basis of ternary phase diagram IRB-loaded SNEDDS were optimized by using Design of Experiments (DoE) and Principal component analysis (PCA) with amount of oil and surfactant: cosurfactant ratio (Km) as factors. The optimized batch of IRB-loaded SNEDDS comprised of 31.62% w/w of Capryol 90 as oil phase, 49.90% w/w Cremophor RH40 as surfactant and 18.48% w/w of Transcutol P as cosurfactant exemplified a mean globule size as 23.94 nm. Further, with an aim to provide enhanced patient compliance the optimized batch of liquid SNEDDS was transformed into SNETs by liquisolid compaction technique. Solid state characterization of IRB-loaded liquisolid mixtures revealed a decrease in the magnitude of crystallinity of IRB. The results of in vitro drug release study of optimized batch of IRB-loaded SNET illustrated a remarkable improvement in the dissolution rate as compared to marketed tablets (Avapro® 75). The results of in vivo pharmacokinetic study on Wister rats revealed 1.78-fold enhancement in oral bioavailability for IRB-loaded SNETs against marketed tablets. The present study proposed SNEDDS as one of the suitable approach for developing nanosized solid oral dosage forms of poorly water soluble drugs like Irbesartan.
Expression Level of the PPP 2 R 5 C Gene in Patients With Acute Myeloid Leukemia and Chronic Myeloid Leukemia

Background: One of the most important B-subunits of protein phosphatase 2A (PP2A) is PPP2R5C, which is involved in both the suppression and promotion of cell growth. Objectives: With regard to this vital role of PPP2R5C, we will examine whether alteration in expression of some proteins is involved in signal transduction, for example the B-subunit of protein phosphatases can be observed in patients with acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). Materials andMethods: We recruited 50 patients with AML and 31 patients with CML, together with 23 individuals in the control group. The expression levels of PPP2R5C and the reference gene B2-MG were determined by SYBR green I real-time PCR. The 2 method was used to present the data of the genes of interest relative to an internal control gene. Results: In this study, significantly higher expression of PPP2R5C was found in the AML (4.13±4.85) compared with healthy individuals. The expression level of PPP2R5C significantly decreased (0.469 ± 0.34) in CML patients compared with healthy individuals. Conclusions: With regard to the critical role of PPP2R5C B-subunit on regulation of PP2A, the change in the expression pattern of PPP2R5C may be a critical finding in AML and CML patients, because it could be a cause of abnormal cell proliferation, differentiation, and transformation in these two groups of patients.
Extent of disease burden determined with magnetic resonance imaging of the bone marrow is predictive of survival outcome in patients with multiple myeloma

Multiple myeloma (MM) remains an incurable cancer. Treatment often is initiated at the time patients experience a progressive increase in tumor burden. The authors of this report investigated magnetic resonance imaging of the bone marrow (BM‐MRI) as a novel approach to quantify disease burden and validated a staging system by correlating BM‐MRI with common clinical and laboratory parameters.
Rapid Waterborne Pathogen Detection with Mobile Electronics

Pathogen detection in water samples, without complex and time consuming procedures such as fluorescent-labeling or culture-based incubation, is essential to public safety. We propose an immunoagglutination-based protocol together with the microfluidic device to quantify pathogen levels directly from water samples. Utilizing ubiquitous complementary metal-oxide-semiconductor (CMOS) imagers from mobile electronics, a low-cost and one-step reaction detection protocol is developed to enable field detection for waterborne pathogens. 10 mL of pathogen-containing water samples was processed using the developed protocol including filtration enrichment, immune-reaction detection and imaging processing. The limit of detection of 10 E. coli O157:H7 cells/10 mL has been demonstrated within 10 min of turnaround time. The protocol can readily be integrated into a mobile electronics such as smartphones for rapid and reproducible field detection of waterborne pathogens.
Safety and efficacy of a non–pesticide‐based head lice treatment: Results of a randomised comparative trial in children

Increasing resistance to pesticide‐based head lice treatments has resulted in the need for alternative products to treat head lice infestations, but there are few clinical studies that have adequately tested these products. This multicentre, randomised, assessor‐blind, parallel‐group phase IV trial compared the safety and efficacy of a non–pesticide‐based head lice shampoo with malathion foam in children.
Pharmacologically induced calcium oscillations protect neurons from increases in cytosolic calcium after trauma

Increases in cytosolic calcium ([Ca2+]i) following mechanical injury are often considered a major contributing factor to the cellular sequelae in traumatic brain injury (TBI). However, very little is known on how developmental changes may affect the calcium signaling in mechanically injured neurons. One key feature in the developing brain that may directly impact its sensitivity to stretch is the reduced inhibition which results in spontaneous [Ca2+]i oscillations. In this study, we examined the mechanism of stretch‐induced [Ca2+]i transients in 18‐days in vitro (DIV) neurons exhibiting bicuculline‐induced [Ca2+]i oscillations. We used an in vitro model of mechanical trauma to apply a defined uniaxial strain to cultured cortical neurons and used increases in [Ca2+]i as a measure of the neuronal response to the stretch insult. We found that stretch‐induced increases in [Ca2+]i in 18‐DIV neurons were inhibited by pretreatment with either the NMDA receptor antagonist, APV [D(‐)‐2‐Amino‐5‐phosphonopentanoic acid], or by depolymerizing the actin cytoskeleton prior to stretch. Blocking synaptic NMDA receptors prior to stretch significantly attenuated most of the [Ca2+]i transient. In comparison, cultures with pharmacologically induced [Ca2+]i oscillations showed a substantially reduced [Ca2+]i peak after stretch. We provide evidence showing that a contributing factor to this mechanical desensitization from induced [Ca2+]i oscillations is the PKC‐mediated uncoupling of NMDA receptors (NMDARs) from spectrin, an actin‐associated protein, thereby rendering neurons insensitive to stretch. These results provide novel insights into how the [Ca2+]i response to stretch is initiated, and how reduced inhibition – a feature of the developing brain – may affect the sensitivity of the immature brain to trauma.
A system framework and API for run-time adaptable parallel software

A system framework supporting run-time dynamic adaptation of parallel applications is proposed. The framework consists of a run-time manager and an API. The run-time manager profiles applications and guides adaption of applications at run-time for optimization and adaptation to the changes of environment such as the number of cores to use. With the proposed API, a range of different parallelization can be provided inside of an application, and the run-time manager chooses an appropriate parallelization at run-time. With the aid of the proposed run-time manager, a program can adapt/morph itself to dynamic changes in the system resources and/or performance requirements at run-time. The proposed adaptive run-time manager monitors and guides the applications to make the system adaptable at run-time.
Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives.

The selective hydroxylation of benzene to phenol, without the formation of side products resulting from overoxidation, is catalyzed by cytochrome P450BM3 with the assistance of amino acid derivatives as decoy molecules. The catalytic turnover rate and the total turnover number reached 259 min-1 P450BM3-1 and 40 200 P450BM3-1 when N-heptyl-l-proline modified with l-phenylalanine (C7-l-Pro-l-Phe) was used as the decoy molecule. This work shows that amino acid derivatives with a totally different structure from fatty acids can be used as decoy molecules for aromatic hydroxylation by wild-type P450BM3. This method for non-native substrate hydroxylation by wild-type P450BM3 has the potential to expand the utility of P450BM3 for biotransformations.
A Global Simulation of Microwave Emission: Error Structures Based on Output From ECMWF's Operational Integrated Forecast System

The European Centre for Medium-range Weather Forecasts (ECMWF) brightness will use temperatures from the soil moisture and ocean salinity mission to analyze root zone soil moisture through a variational data assimilation system. The first guess is obtained from numerical weather prediction (NWP) model fields, an auxiliary database, and a land surface microwave emission model. In this paper, we present the community microwave emission model and research the first-guess errors in L-band brightness temperatures. An error propagation study is performed on errors introduced through: (1) uncertainties in the parameterizations of the radiative transfer model; (2) auxiliary geophysical quantities for the radiative transfer computations; and (3) an imperfect NWP model. It is found that the vegetation and dielectric models introduce uncertainties with a difference of up to 25 K between models. However, the biggest error in brightness temperature is likely related to the use of an auxiliary vegetation database, which results in differences of -20 to +20 K in our simulations. These potential errors are in many regions higher than the variance in brightness temperatures related to an imperfect NWP model.
RF CMOS$LC$-Oscillator With Source Damping Resistors

This letter proposes a new method to suppress the 1/f noise contribution of active devices in an oscillator using source damping resistors. The operational mechanism of the proposed source damping resistor method is analyzed through circuit simulation with a complementary LC-oscillator. The reduced 1/f noise leads to the phase noise improvement by suppressing 1/f noise up-conversion to phase noise. The measurement result shows that there is about 6.0dBc and 4.0dBc of phase noise improvement at 10kHz and 100kHz offset frequency with differential complementary LC-oscillator topology, respectively
Delay performance of MISO wireless communications

Ultra reliable, low latency communications (URLLC) are currently attracting significant attention due to the emergence of mission-critical applications and device-centric communication. URLLC will entail a fundamental paradigm shift from throughput-oriented system design towards holistic designs for guaranteed and reliable end-to-end latency. A deep understanding of the delay performance of wireless networks is essential for efficient URLLC systems. In this paper, we investigate the network layer performance of multiple-input, single-output (MISO) systems under statistical delay constraints. We provide a statistical characterization of MISO diversity-oriented service process through closed-form expressions of its Mellin transform and derive probabilistic delay bounds using tools from stochastic network calculus. In particular, we analyze transmit beamforming with perfect and imperfect channel knowledge and compare it with orthogonal space-time codes and antenna selection. The effect of transmit power and number of antennas on the delay distribution is also investigated. Our results provide useful guidelines for the design of communication systems that can guarantee the stringent URLLC latency requirements.
Effects of polysaccharides from Cordyceps sinensis mycelium on physical fatigue in mice

This study was designed to determine the effects of polysaccharides from Cordyceps sinensis mycelium (CSP) on physical fatigue in mice. The mice were randomly divided into four groups (n = 16 in each group), i.e. control group, low-dose CSP treated group, intermediate-dose CSP treated group and high-dose CSP treated group. The mice in the treated groups received CSP (100, 200 and 400 mg/kg, ig), and the mice in the control group received drinking water ig. After 28 days, a forced swimming test was performed and some biochemical parameters related to fatigue were examined. The present data suggested that CSP could extend the exhaustive swimming time of mice, as well as increase the hepatic glycogen and muscle glycogen levels, and decrease the blood lactic acid and BUN levels. These results indicated that CSP had anti-fatigue effects.
3-(Dihydroxyboryl)anilinium 6-carboxypyridine-2-carboxylate

In the anion of the title molecular salt, C6H9BNO2 +·C7H4NO4 −, the dihedral angles between the –COO2− and –CO2H groups and their attached ring are 4.02 (13) and 21.41 (10)°, respectively. The B atom in the cation adopts a syn–syn geometry and the dihedral angle between the –B(OH)2 group and its attached ring is 11.06 (5)°. In the crystal, O—H⋯O, N—H⋯O and N—H⋯N hydrogen bonds link the components into a three-dimensional network.
Breast thermography and pseudo-coloring presentation for improving gray infrared images

Breast cancer is the most common cancer in women (about 30% of all cancers). And is also the second common cancer after lung cancer. One woman out of eight develops breast cancer during lifetime. Breast thermography has a unique role in early detection of breast cancer and in this regards none of the other method such as mammography. The role of infrared imaging in early detection of breast cancer as an adjunct tool to mammography has been proved. Thermograms are usually provided in gray level images but Findings show gray images are not appropriate for human interpretation. Human beings can only discern a few dozen gray level values while they can distinguish thousands of colors. So In order to help thermologists to find abnormal regions in the thermograms, it's better to color thermograms. So pseudo-coloring of thermogram is one of the important factors for accurate diagnosis. In this research we offer comparing some common pseudo-coloring algorithm. Also a nonlinear function transform for pseudo-coloring of infrared breast images based on physiological properties of human eye is proposed, and it's efficiency is shown by experience.
Fuzzy logic based harmonic elimination in single phase inverters

A fuzzy system for the elimination of specific low order harmonics in the output voltage of single phase inverters is proposed. The proposed system does not need look up tables which require much memory as in traditional methods and no need for training which takes much time as in neural networks. Here, modulation index is used as input to fuzzy system and switching signals are generated. Predetermined low order harmonics are successfully eliminated.
Decontamination of Liquid Radioactive Wastes Using Clay Minerals

Nukleer enerji ve radyoizotoplarin kullanimindaki hizli artis, radyoaktif atiklarin aktiviteden aritilmasi icin etkili ve ekonomik yontemler gelistirilmesini gerektirmektedir. Bu calismada, 137 Cs izotopunu iceren dusuk aktiviteli radyoaktif atiklarin, killer yardimiyla aktiviteden arindirilmasi incelenmistir. Aktivite tutucu materyal olarak kullanilan kil ornekleri Turkiye’nin cesitli yorelerindeki (Adana, Konya, Diyarbakir) kil yataklarindan saglanmistir. Kolon giris ve cikis derisimleri, gama ( g ) spektrometresi kullanilarak radyometrik yontemle saptanmistir. Bu arastirma sonuclarina gore “smektit” turundeki Turkiye killer radyosezyum iceren radyoaktif atiklarin aritilmasi icin elverisli oldugu bulunmustur.
The prognostic value of routinely performed minor salivary gland assessments in primary Sjögren's syndrome

Objectives To investigate the prognostic value of the lymphocytic focus score (LFS) and the percentages of IgA+, IgM+ and IgG+ plasma cells for disease severity of primary Sjögren syndrome (pSS). Methods Medical charts of 174 pSS patients were retrospectively analysed, comparing histology results (LFS and percentages of IgA+, IgM+ and IgG+ plasma cells) with disease outcomes as non-Hodgkin lymphoma (NHL) and clinical scores including cumulative EULAR (European League against Rheumatism) Sjögren syndrome disease activity index (ESSDAI) and the total number of extraglandular manifestations. Results The mean LFS was significantly higher in patients developing NHL (3.0±0.894 vs 2.25±1.086; p=0.021). The threshold of ≥3 foci has a positive predictive value of 16% for lymphoma, and a negative predictive value of 98%. Only LFS ≥3 contributed significantly and independently to NHL development in a standard multiple regression model. Ig class distribution of plasma cells did not help to identify patients developing lymphoma. Patients with LFS ≥3, ≤40% IgA+ or ≥25% IgM+ plasma cells in salivary gland biopsy specimens had significantly enhanced systemic disease. Conclusions Routine histopathological minor salivary gland assessment has important prognostic value. The LFS might help to identify patients with an increased risk for lymphoma.
Engaged Problem Formulation in IS Research

“Is this the problem? ”: the question that haunts many information systems (IS) researchers when they pursue work relevant to both practice and research. Nevertheless, a deliberate answer to this question requires more than simply asking the involved IS practitioners. Deliberately formulating problems requires a more substantial engagement with the different stakeholders, especially when their problems are ill structured and situated in complex organizational settings. On this basis, we present an engaged approach to formulating IS problems with, not for, IS practitioners. We have come to understand engaged problem formulation as joint researching and as the defining of contemporary and complex problems by researchers and those practitioners who experience and know these problems. We used this approach in investigating IS management in Danish municipalities. In this paper, we present the approach to formulating problems in an engaged way. We discuss it in relation to ideas and assumptions that underpin engaged scholarship, and we discuss the implications for IS action research, design science research, and mixed approaches.
Bremsstrahlung dose of therapeutic beta nuclides in bone and muscle

In the nuclear medicine, beta nuclides are released during the treatment. This beta interacts with bone and muscle and produces external Bremsstrahlung (EB) radiation. Present work formulated a new method to evaluate the EB spectrum and hence the Bremsstrahlung dose of therapeutic beta nuclides (Lu-177, Sr-90, Sm-153, I-153, Cs-137, Au-201, Dy-165, Mo-99, Sr-89, Fe-59, P-32, Ho-166, Sr-92, Re-188, Y-90, Pr-147, Co-60, K-42) in bone and muscle. The Bremsstrahlung yields of these beta nuclides are also estimated. Bremsstrahlung production is higher in bone than that of muscle. Presented data provides a quick and convenient reference for radiation protection and it can be quickly employed to give a first pass dose estimate prior to a more detailed experimental study.
Prioritizing Strategic IT Projects with Tropos Andreas Gehlert

One of the daily tasks of an enterprise architect is to prioritize strategic IT projects. To achieve a business-IT alignment, this prioritization needs to be based on business strategies and goals. Therefore, business goals and their traceability to strategic IT projects are relevant for the enterprise architect. However, surprisingly little formalisations and reasoning techniques have been developed in the enterprise architecture domain. In this paper we show that the popular goal modelling technique Tropos together with its formal reasoning techniques can support the enterprise architect when prioritizing strategic IT projects. We prove the feasibility of our work with a tool implementation of the proposed modelling language and its corresponding algorithms; and demonstrate their usefulness with the help of an example taken from the enterprise architecture literature.
Sociodemographic Predictors of Health-Related Quality of Life and Healthcare Service Utilisation among Young Refugees in South Australia

Although refugee adolescents and children are recognised as a health risk population, few studies have explored their Health-related Quality of Life (HRQOL). The present study investigated 1) the sociodemographic predictors of HRQOL such as ethnicity, trauma exposure, and length of residency in Australia in a multiethnic paediatric population with refugee experiences and 2) the relationship between mental healthcare utilisation and HRQOL. Method: Participants were 458 adolescents and children, aged 4 - 17 years, living in South Australia. Parents provided data across the sample and adolescents also completed questionnaires. Overall HRQOL and its composite functional dimensions were assessed using the Paediatric Quality of Life (PedsQL) instrument. Questions from the Child and Adolescent Component of the Australian National Survey of Mental Health and Wellbeing were used to assess service utilisation. Results: Migration region/ethnicity predicted better HRQOL as well as physical, emotional and psychosocial functioning for both children and adolescents. African youths indicated higher HRQOL than those from the former Yugoslavia and the Middle East/South Asia respectively. Pre-migration trauma exposure was associated with lower HRQOL; and longer stay in Australia was related to lower emotional functioning in children. There was a negative association between healthcare service utilisation and PedsQL scores, with participants accessing services demonstrating lower HRQOL. Conclusion: Using more rigorous methods, future research is needed to investigate additional sociodemographic predictors of HRQOL, and protective/risk factors that impact on HRQOL of young refugees.