Miracle-dz/UniFAR-FTUs huggingface dataset:
Overexpression of Regulatory T Cells Type 1 (Tr1) Specific Markers in a Patient with HCV-Induced Hepatocellular Carcinoma

Hepatitis C virus (HCV) is an important causative agent of liver disease, but factors that determine the resolution or progression of infection are poorly understood. In this study, we suggested that existence of immunosuppressive mechanisms, supported by regulatory T cells and especially the regulatory T cell 1 subset (Tr1), may explain the impaired immune response during infection and thus the fibrosis aggravation to hepatocellular carcinoma (HCC). Using quantitative real-time PCR, we investigated the intra-hepatic presence of Tr1 cells in biopsies from a genotype 1b infected patient followed for an 18-year period from cirrhosis to HCC. We described a significant increase of gene expression in particular for the cytokines IL-10, TGF-β, and their receptors that were perfectly correlated with an increased expression of the Tr1 specific markers (combined expression of CD4, CD18, and CD49b). This was strongly marked since the patient evolved in the pathology and could explain the failure of the treatment. In conclusion, evidence of regulatory T cell installation in the liver of chronically infected patient with cirrhosis and HCC suggests for the first time a key role for these cells in the course of HCV infection.
MODEST: A model for energy estimation under spatio-temporal variability

Estimation of static and dynamic energy of caches is critical for high-performance low-power designs. Commercial CAD tools performing energy estimation statically are not aware of the changing operating and environmental conditions which makes the problem of energy estimation more dynamic in nature. It is worsened by process induced variations of low level parameters like threshold voltage and channel length. In this paper we present MODEST, a proposal for estimating the static and dynamic energy of caches taking into account spatial variations of physical parameters, temporal changes of supply voltage and environmental factors like temperature. It can be used to estimate the energy of different blocks of a cache based on a combination empirical data and analytical equations. The observed maximum and median error between MODEST and HSPICE energy-estimates for 22,500 samples is around 7.8% and 0.5% respectively. As a case study, using MODEST, we propose a two step iterative optimization procedure involving Dual-Vth assignment and standby supply voltage minimization for reclaiming energy-constrained caches. The observed energy reduction is around 50.8% for the most-leaky Cache. A speed-up of 750X over conventional hard-coded implementation for such optimizations is achieved.
Measuring Offender Attributes and Engagement in Treatment Using the Client Evaluation of Self and Treatment

Monitoring drug-abuse-treatment delivery and progress requires the use of validated instruments to measure client motivation, psychosocial and cognitive functioning, and other treatment-process dynamics. As part of the National Institute on Drug Abuse Criminal Justice Drug Abuse Treatment Studies project for examining client-performance indicators for treatment of correctional populations, this study examined psychometric properties of the Criminal Justice Client Evaluation of Self and Treatment (CJ CEST). The sample included 3,266 offenders from 26 corrections-based treatment programs located in six states. Overall, the client assessment demonstrated good reliabilities evaluated at the individual and program levels and in test—retest administrations. In addition, evidence for construct validity was favorable. It is concluded that the CJ CEST is a brief yet comprehensive instrument that effectively and efficiently measures client needs and functioning at intake and also is appropriate for use during treatment to monitor progress over time in corrections-based drug-treatment programs.
Analysis of shielding eficiency of a high voltage laboratory via the FDTD method by using sub-cellular conductive sheets

This work presents results regarding electromagnetic shielding structures. The simulations were performed by using the finite difference time domain method, in which a sub-cellular formulation has been implemented for modeling thin steel walls. The implementation was validated via comparison of the obtained results to those available in the literature. Then, several geometries were tested, including apertures on the structures and the space between double shielding walls. Finally, a complete high-voltage laboratory was simulated (by analyzing the shielding efficiency).
RESEARCH REPORTS Relationship of Core Self-Evaluations to Goal Setting, Motivation, and Performance

A newly developed personality taxonomy suggests that self-esteem, locus of control, generalized self-efficacy, and neuroticism form a broad personality trait termed core self-evaluations. The authors hypothesized that this broad trait is related to motivation and performance. To test this hypothesis, 3 studies were conducted. Study 1 showed that the 4 dispositions loaded on 1 higher order factor. Study 2 demonstrated that the higher order trait was related to task motivation and performance in a laboratory setting. Study 3 showed that the core trait was related to task activity, productivity as measured by sales volume, and the rated performance of insurance agents. Results also revealed that the core selfevaluations trait was related to goal-setting behavior. In addition, when the 4 core traits were investigated as 1 nomological network, they proved to be more consistent predictors of job behaviors than when used in isolation.
Pervasive Digital Monitoring and Transmission of Pre-Care Patient Biostatics with an OSGi, MOM and SOA Based Remote Health Care System

Telemedicine applications are evolving quickly as information technologies improve. New requirements from users and changes in business processes make it necessary to frequently alter applications. Developers are responsible for redesigning the applications on both the user and server sides to meet the latest requirements. This is both time consuming and expensive. A new approach is needed to improve the support of application construction and to reduce the costs involved. In this paper, we use OSGi as a platform, on which to combine components in order to form new functionalities used pervasively in different devices on the user side. Examples include cell phones, PDAs, and home gateways. For server side applications, we divided the health care system into several layers and combined the services provided by these modules using a loose-coupling mechanism - process choreography. When the requirements or system flows of the telemedicine server are changed, the proposed system can adapt to meet new needs by replacing the bundles on the edge server and reconfiguring the business process used in the health care system.
Recommending Related Articles in Wikipedia via a Topic-Based Model

Wikipedia is currently the largest encyclopedia publicly available on the Web. In addition to keyword search and subject browsing, users may quickly access articles by following hyperlinks embedded within each article. The main drawback of this method is that some links to related articles could be missing from the current article. Also, a related article could not be inserted as a hyperlink if there is no term describing it within the current article. In this paper, we propose an approach for recommending related articles based on the Latent Dirichlet Allocation (LDA) algorithm. By applying the LDA on the anchor texts from each article, a set of diverse topics could be generated. An article can be represented as a probability distribution over this topic set. Two articles with similar topic distributions are considered conceptually related. We performed an experiment on the Wikipedia Selection for Schools which is a collection of 4,625 selected articles from the Wikipedia. Based on some initial evaluation, our proposed method could generate a set of recommended articles which are more relevant than the linked articles given on the test articles.
An assessment of patient satisfaction with nonoperative management of clavicular fractures using the disabilities of the arm, shoulder and hand outcome measure.

BACKGROUND Clavicle fractures historically have been managed without internal fixation. Current literature is raising questions regarding this management as opposed to offering operative fixation in some instances. This study addresses the use of the Disabilities of the Arm, Shoulder and Hand (DASH) outcomes measure to identify those that have the least satisfaction with nonoperative care of the clavicle fracture based upon clavicular deformity and variation in fracture location based upon Allman Classification. METHODS Patients having suffered clavicle fractures were mailed the DASH Outcomes Questionnaire to be completed and returned. A total of 113 surveys were returned completed with 92 being of value for evaluation. Patient chest or clavicle radiographs were evaluated, and measurements were made of the clavicle fractures for amount of separation or shortening and grade according to Allman Classification. Statistical evaluation compared DASH Scores (patient satisfaction as outcome measure) to the Allman Classification and the degree of separation or shortening. Comparison of categorical variables was performed using Fisher's exact test. Comparison of continuous variables was preformed using Student's t test. Statistical significance was demonstrated by a p value of less than 0.05. RESULTS Patients with clavicular shortening of greater than 2 cm were found to have the highest DASH score indicating dissatisfaction and disability with their outcome postinjury (p = 0.0001). Separation or lengthening seemed to be associated with lower DASH Scores. Patients with Allmen Classification I (midshaft clavicle) fractures had higher DASH score than other fracture locations (p = 0.0001). CONCLUSIONS Patients with midshaft clavicle fractures with shortening of greater than 2 cm may be good candidates for operative repair given the degree of dissatisfaction with nonoperative management of these fractures as assessed by long-term outcome measures of disability.
Effect of menstrual cycle on resting brain metabolism in female rhesus monkeys

Little is known about the effects of the menstrual cycle on brain activity in primates. Here, we use 18F-fluorodeoxyglucose positron emission tomography to monitor changes in resting brain glucose metabolism across the menstrual cycle in female rhesus monkeys. Results showed greater activity in right lateral orbitofrontal cortex, a region involved in processing negatively valenced emotional stimuli, in the follicular compared with luteal phase. Estradiol levels were negatively correlated with activity in cortical and brainstem regions involved in emotional processing, and positively correlated with activity in areas involved in cognitive control and emotion regulation. In summary, the data suggest that in primates, fluctuations of ovarian hormones across the menstrual cycle influence activity in brain areas involved in emotion and its regulation.
Dynamic cyber-incident response

Traditional cyber-incident response models have not changed significantly since the early days of the Computer Incident Response with even the most recent incident response life cycle model advocated by the US National Institute of Standards and Technology (Cichonski, Millar, Grance, & Scarfone, 2012) bearing a striking resemblance to the models proposed by early leaders in the field e.g. Carnegie-Mellon University (West-Brown, et al., 2003) and the SANS Institute (Northcutt, 2003). Whilst serving the purpose of producing coherent and effective response plans, these models appear to be created from the perspectives of Computer Security professionals with no referenced academic grounding. They attempt to defend against, halt and recover from a cyber-attack as quickly as possible. However, other actors inside an organisation may have priorities which conflict with these traditional approaches and may ultimately better serve the longer-term goals and objectives of an organisation.
Using the AgreementMaker to Align Ontologies for the OAEI Campaign 2007

In this paper, we present the AgreementMaker, an ontology alignment tool that incorporates the Descendants Similarity Inheritance (DSI) method. This method uses the structure of the ontology graphs for contextual information, thus providing the matching process with more semantics.We have tested our method on the ontologies included in the anatomy track of the OAEI 2007 campaign.
Fast and Accurate Interval-Based Timing Estimator for Variability-Aware FPGA Physical Synthesis Tools

Process variations of deep sub-micron technologies have created significant timing uncertainty. This generates the need for a new variability-aware physical synthesis tool for Field-Programmable Gate-Arrays (FPGAs). Ideally, variability-aware tools should be able to perform both timing variability estimation during the synthesis and timing variability analysis after the synthesis. Statistical static timing analysis (SSTA) methods are developed to perform timing variability analysis, but are computationally expensive and not fast enough. We propose a fast and accurate interval-based method for the timing variability estimation. This method uses correlation-aware affine intervals instead of probability density distributions to model timing uncertainties. Our model estimates the mean of timing variation within an accuracy of 99.9% and an average range looseness of -7.5% for the Monte Carlo (MC) model. A speed-up of about SOX and 4900X is achieved for the Correlation Aware Canonical Timing (CACT) model and MC model respectively.
Part-of-Speech Tagging of Transcribed Speech

We used four Part-of-Speech taggers, which are available for research purposes and were originally trained on text to tag a corpus of transcribed multiparty spoken dialogues. The assigned tags were then manually corrected. The correction was first used to evaluate the four taggers, then to retrain them. Despite limited resources in time, money and annotators we reached results comparable to those reported for the taggers on text. Based on our experience we present guidelines to produce reliably POS tagged corpora of new domains.
The Graded Reader Is Dead, Long Live the Electronic Reader

Many course books for learners of English as a second or foreign language now claim to contain a strong lexical component. Other practitioners meanwhile continue to advocate the use of graded readers to augment vocabulary development. This article reports the findings of vocabulary profiling and analysis of both course books and graded readers and reveals that in neither case do the approaches taken to vocabulary development fully account for recent research into vocabulary acquisition and vocabulary pedagogy. The results of this study establish principles that are used to revisit the graded reader concept and develop a series of ‘eReaders’ within a framework of corpus-based studies and Web 2.0 applications. Initial results in piloting these eReaders suggest that a principled corpus-informed approach to text construction and exploitation has strong potential to help learners develop both an in-depth and productive knowledge of the most frequently used words in English, and thereby fill the void left by traditional methods of dealing with vocabulary development.
A case-based reasoning framework for music playlist recommendations

Recommender Systems have recently become a fundamental part of various applications intending to support the users when searching for information, products and services that could be interested in at a given moment. While the majority of the current Recommender Systems generate Isolate item recommendations based on user-item interactions, mainly expressed through ratings, this paper presents a system generating recommendations of sets of items. The objective of this system is to generate accurate recommendations in domains where users are looking for a more complete experience, in terms of joint item selections, and where the complexity of the related information cannot be evaluated and treated efficiently using the actual systems, like in the music playlist recommendations. In order to identify the underlying relations between songs, their styles and the artists that perform those, a hybrid Case-Based Reasoning approach combined with a graph model is used. This framework was designed with the scope to overcome the semantic gap present in multimedia recommendations, and at the same time, to be able to perform better in cold start situations. The experimentation results presented, show that the proposed approach is able to deliver recommendations of equal and higher accuracy than some of the widely used recommendation methods.
Hydrogen ion block of the sodium pore in squid giant axons

The block of squid axon sodium channels by H ions was studied using voltage-clamp and internal perfusion techniques. An increase in the concentration of internal permeant ions decreased the block produced by external H ions. The voltage dependence of the block was found to be nonmonotonic: it was reduced by both large positive and large negative potentials. The ability of internal ions to modify the block by external H+ is explained by a competition among these ions for a binding site within the pore. The nonmonotonic voltage dependence is consistent with this picture if the hydrogen ions are allowed to be permeant.
CHANGES IN BAR‐PATH KINEMATICS AND KINETICS AFTER POWER‐CLEAN TRAINING

The purpose of this study was to investigate the direction and magnitude of kinematic changes in bar path and kinetic variable changes in the power clean (PC) after 4 weeks of PC training. Eighteen healthy adult men who had a minimum of 1 year of previous experience in the PC participated as subjects in this study. The subjects were pretested for their 1 repetition maximum (1RM) and provided with visual and verbal cues during PC training sessions, which took place 3 times per week for 4 weeks. Variables measured during data collection include pre–and post–peak force, peak power, and several bar-path kinematic variables through videography at 50, 70, and 90% of the subjects' pre-1RM. Peak force was improved at 50% of 1RM from 936 ± 338 N to 1,299 ± 384 N, at 70% from 1,216 ± 315 N to 1,395 ± 331 N, and at 90% from 1,255 ± 329 N to 1,426 ± 321 N. Peak power was increased at 50% of 1RM from 3,430 ± 1,280 W to 4,230 ± 1,326 W. All variables with respect to bar-path kinematics were improved significantly. These results indicate that both kinematic and kinetic variables improve through training and feedback. It is possible that persons beginning the PC exercise or coaches who provide instruction on the PC to beginning lifters should focus on proper bar path during the movement. This may result in force and power output to develop as technique improves. However, further investigation is required to establish the link between bar-path changes and kinetic variable performance improvements.
SEXUAL DYSFUNCTIONS AND ASSOCIATED FACTORS IN WOMEN OF REPRODUCTIVE AGE

Background and aim : Sexual function is associated with emotional-physiological, cultural and personal factors. World Health Organization recently defined sexual health as "the experience of the ongoing process of physical, psychological and sociocultural well-being related to sexuality. Sexual dysfunctions are particularly prevalent among women seeking routine gynecological care. Addressing sexual problems is an essential part of health care standards. The Aim of this study was to determine sexual satisfaction, sexual function disorders and associated factors in women of reproductive age who attended to Dezful health centers , Iran in 1387 . Data were analyzed by SPSS statistical software Material and Method: A descriptive- cross-sectional design was used. The sample of the study consisted of 250 women of reproductive age who attended to Health centers in Dezful ,Iran. Data were collected by a demographic questionnaire, and sexual function questionnaire . The validity of questionnaire was determined by content validity. Reliability was confirmed by test re-test. Findings: Mean score of total sexual function was 27 / 4 ± 7 / 3. The study findings showed that 64/6% of respondents had sexual dysfunction. There was also a significant correlation between sexual satisfaction and sexual function (p<0.001). The results of this study indicated that the majority of participations (78/6%) experienced good sexual satisfaction. Domain of sexual desire and sexual function indicated significant correlation with age, marriage age and educational level (p<0.05). Conclusion: The findings of this study indicated that inability at induce a health communication and pleasure with sexual wife is followed physical, psychological and social disorder for woman and her wife. Young couple education can caused correct recognition from sexual communication at pre marriage counsels. The findings of this study indicated that prevalence of sexual dysfunction are high, hence survey both men and women is essential and important. Keyword : Sexual function, Sexual dysfunction Female sexual disorders .
Endogenous Explanation in the Sociology of Culture

This paper examines recent work in the sociology of culture devoted to providing endogenous explanations of cultural phenomena. The focus is on works that provide cultural explanations of cultural processes, as opposed to the social structural and “production of culture” explanations otherwise predominant in the literature. I examine three distinct approaches: a “post-hermeneutic” approach devoted not to the question of cultural interpretation but to the issue of subjects' manipulation of culture in the quest for meaning; a semiotic approach focused on the mechanics of symbol systems; and an ecological approach that emphasizes the role of competition and niche density in explaining both cultural stasis and change. The three approaches have in common a general lack of interest in traditional conceptions of meaning (verstehen), choosing instead to focus on issues related to the internal structure and dynamics of cultural expression. This marks a new opportunity for synthesis and exploration in a field tradi.