Miracle-dz/UniFAR-FTUs huggingface dataset:
Group Psychoeducation for Relatives of Persons With Bipolar Disorder: Perceived Benefits for Participants and Patients

Abstract Psychoeducation is a key element in the management of patients with bipolar disorders. The present study explored the perception of patients and family members with respect to group psychoeducation for relatives. Patients (n = 20) and relatives (n = 26) were assessed with questionnaires about perceived benefits and quality of life (median 4 years after participation). A large majority (>80%) of relatives acknowledged benefits with respect to easier detection of the early warning signs of relapse, improved quality of life, feeling more involved, and engaging in higher quality caregiving activities. Patients were less positive in general, but agreed that the program had helped them deal with crises, increased their feeling of being understood by relatives, and promoted positive changes in the family (>60%). Perceived positive changes in the family were associated with higher quality of life for relatives and patients. The present study highlights the importance of communication enhancement in group psychoeducation for relatives.
Preparation and properties of immobilized flavokinase

Flavokinase (ATP: riboflavin 5'‐phosphotransferase, EC 2.7.1.26) purified from rat liver by affinity chromatography, has been immobilized by amide linkage to aminoalkyl‐agarose beads. The immobilized enzyme differs from the soluble enzyme in having greater stability slightly higher Km for the substrates, riboflavin and ATP, a broader pH optimum, and a lower energy of activation. These results suggest that the immobilized enzyme is influenced by the microenvironment of the bead and is subject to some degree of internal diffusional limitation. A Small (3ml), continuous, plug‐flow reactor prepared with immobilized flavokinase effects 5% conversion of riboflavin to riboflavin 5′‐phosphate (FMN) with a flow rate of 0.16 ml/min, which corresponds to an output of 5 nmol FMN/min. Immobilized flavokinase is effective for phosphorylating riboflavin and numerous riboflavin analogs and provides a facile methods for preparing exclusively, unlike other synthetic methods, the 5′‐phosphates.
A 12-Gb/s transceiver in 32-nm bulk CMOS

A 12-Gb/s transceiver in 32-nm bulk CMOS in described. Features include an 8.8–12.4-GHz LC-PLL with 0.4-ps jitter; a full-swing DLL and phase interpolator with LSB=2.6 ps and DNL≪1.2 ps; a 4.2-mW receiver front end with de-muxing comparator and precharge removal latch; and an all-digital duty cycle correction (DCC) loop. The transceiver receives and transmits PRBS23 data at 12 Gb/s with BER≪10−12 over a 6-in FR4 channel with 10 dB of loss, while consuming 37.8 mW (3.15 pJ/bit) from a 1-V supply, not including clock generation. A chip-to-chip link transmits and receives PRBS15 data at 11.6 Gb/s with BER≪10−12 over a 12-in. FR4 channel.
Energy-performance tradeoffs in IaaS cloud with virtual machine scheduling

In the cloud data centers, how to map virtual machines (VMs) on physical machines (PMs) to reduce the energy consumption is becoming one of the major issues, and the existing VM scheduling schemes are mostly to reduce energy consumption by optimizing the utilization of physical servers or network elements. However, the aggressive consolidation of these resources may lead to network performance degradation. In view of this, this paper proposes a two-stage VM scheduling scheme: (1) We propose a static VM placement scheme to minimize the number of activating PMs and network elements to reduce the energy consumption;(2) In the premise of minimizing the migration costs, we propose a dynamic VM migration scheme to minimize the maximum link utilization to improve the network performance. This scheme makes a tradeoff between energy efficiency and network performance. We design a new two-stage heuristic algorithm for a solution, and the simulations show that our solution achieves good results.
Supplementary Materials for Dual Set Multi-Label Learning

Chong Liu, Peng Zhao, Sheng-Jun Huang, Yuan Jiang, Zhi-Hua Zhou 1 National Key Laboratory for Novel Software Technology, Nanjing University, Nanjing 210023, China 2 Collaborative Innovation Center of Novel Software Technology and Industrialization, Nanjing 210023, China 3 College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China {liuc, zhaop, jiangy, zhouzh}@lamda.nju. edu.cn, huangsj@nuaa.edu.cn
Generation and control of accelerating airy beams in nonlinear photonic crystals

Airy beams [1] are beams whose transverse amplitude dependence at origin is defined by the Airy function. These beams have several unique properties: They are termed “non-diffracting” since the infinite Airy wavepacket does not spread as it propagates, and “accelerating”, since this wavepacket is centered around a parabolic trajectory in space. These unique features are still observed to a large extent with truncated Airy beams, in which the Airy function distribution is multiplied by either a Gaussian or an exponential window. Possible applications of Airy beams include optical micro-manipulation of small particles, generation of curved plasma channels in air and generation of Airy-Bessel light bullets. Moreover, the Airy beam is only one example of an accelerating beam: Accelerating parabolic beams are non-diffracting and freely accelerating beams that form an orthogonal and complete set of solutions to the paraxial wave equation.
Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis

Sialorrhoea is a socially disabling problem in bulbar amyotrophic lateral sclerosis (ALS). Botulinum toxin A (BoNT/A) was injected into the salivary glands in five patients with bulbar ALS and sialorrhoea. The effect of BoNT/A was measured by the number of paper handkerchiefs used each day and by salivary gland scintigraphy. BoNT/A ameliorated sialorrhoea and quality of life without major adverse effects. BoNT/A may be a relatively safe and effective treatment for sialorrhoea in selected patients.
A higher order curvature corrected 2 ppm/°C CMOS voltage reference circuit

A low power, low temperature coefficient and ultra-stable higher order curvature compensated CMOS voltage reference circuit has been designed for use in energy harvesting applications. The circuit can provide a stable reference of 543 mV over a wide supply voltage range from 0.69V to 2.5 V with a line sensitivity of 0.05% / V. The circuit has been designed in 65 nm DTCMOS process. The novelty is the use of a simple higher order curvature correction topology to suppress the reference voltage variation at higher temperatures without any complex circuits. The proposed circuit achieves a temperature coefficient of 2ppm/°C over a wide temperature range of -30°C to +140°C. The power supply rejection ratio is -65 dB from DC to 1kHz and the power consumption at 1V is 60 nW. A calibration methodology is also briefly discussed with optimum results to reduce the reference voltage spread across corners.
Consumer E-Health: An Overview of Research Evidence and Implications for Future Policy

Consumer e-health is rapidly becoming a fundamental component of healthcare. However, to date only provisional steps have been taken to increase our understanding of how consumers engage with e-health. This study, an interpretive review, assessed the evidence about consumer use of e-health and identified five categories that encompass consumer e-health: (i) peer-to-peer online support groups; (ii) self-management/self-monitoring applications; (iii) decision aids; (iv) the personal health record; and (v) Internet use. Our findings reveal that e-health offers consumers many possibilities and potential benefits, although there appears to be apprehension concerning the efficacy of some interventions and barriers relating to the trustworthiness of Internet-acquired information. It is imperative that policy initiatives address these issues to ensure that consumer e-health services can be effectively, efficiently, and safely accessed.
Optimization of Surfactant-Mediated, Ultrasonic-assisted Extraction of Antioxidant Polyphenols from Rattan Tea (Ampelopsis grossedentata) Using Response Surface Methodology

Background: Rattan tea is a medicinal plant that has been used for many years for the treatment of inflammation, fatty liver, tumor, diabetes, and hyperlipidemia. Objective: A green and novel approach based on surfactant-mediated, ultrasonic-assisted extraction (SM-UAE) was developed for the extraction of antioxidant polyphenols from Rattan tea. A nonionic surfactant Tween-80 was selected as extraction solvent. The antioxidant activity was measured by total phenolic content (TPC) and ferric-reducing/antioxidant capacity (FRAC) assay. Materials and Methods: Optimization of extraction parameters including concentration of solvent, ultrasonic time, and temperature were investigated by response surface methodology. The antioxidant activity was measured by TPC and FRAC assay. Results: The optimal extraction conditions were determined as 6.8% (v/v) of aqueous Tween-80, ultrasonic temperature of 54°C, and ultrasonic time of 28.8 min. Under these conditions, the highest TPC value of 360.4 mg gallic acid equivalent per gram of dry weight material (GAE/g DW) was recorded. Moreover, 6.8% (v/v) of aqueous Tween-80, ultrasonic temperature of 54.5°C, and ultrasonic time of 28.4 min were determined for the highest FRAC value of 478.2 μmol of Fe2+/g of weight material (μmol Fe2+/g DW). Compared with other methods, the TPC and FRAC values of 313.5 mg GAE/g DW and 389.6 μmol Fe2+/g DW were obtained by heat reflux extraction using ethanol as solvent, respectively, and 343.2 mg GAE/g DW and 450.1 μmol Fe2+/g DW were obtained by UAE using ethanol as solvent, respectively. Conclusion: The application of SM-UAE markedly decreased extraction time or extraction cost and improved the extraction efficiency, compared with the other methods. Abbreviations used: SM-UAE: Surfactant-mediated ultrasonic-assisted extraction; TPC: total phenolic content; FRAC: Ferric reducing antioxidant capacity; RSM: Response surface methodology; BBD: Box-Behnken design.
Ambulatory blood pressure measurement as a predictor of outcome in an Irish population: methodology for ascertaining mortality outcome

BackgroundAmbulatory blood pressure monitoring (ABPM) has proven to be a superior predictor of morbid events when compared to clinic or office blood pressure measurement (CBPM). The purpose of this study was to evaluate the predictive value of ABPM in a sample of 14 414 people referred for management of cardiovascular risk. MethodsIn this paper we describe the methodology required to examine mortality outcome in the absence of a national unique identifier. ResultsUsing a computerized database of deaths we were able to establish that 1348 people had died by the end of the follow-up period (30 September 2002). Sixty-four percent of deaths were cardiovascular and in 207 subjects who had post-mortem examinations, 78% were cardiovascular. ConclusionsThe accurate identification of the cause of death in a large population will allow comparison of the relative predictive power of APBM and CBPM in an Irish population.
Dhalion: Self-Regulating Stream Processing in Heron

In recent years, there has been an explosion of large-scale real-time analytics needs and a plethora of streaming systems have been developed to support such applications. These systems are able to continue stream processing even when faced with hardware and software failures. However, these systems do not address some crucial challenges facing their operators: the manual, time-consuming and error-prone tasks of tuning various configuration knobs to achieve service level objectives (SLO) as well as the maintenance of SLOs in the face of sudden, unpredictable load variation and hardware or software performance degradation. In this paper, we introduce the notion of self-regulating streaming systems and the key properties that they must satisfy. We then present the design and evaluation of Dhalion, a system that provides self-regulation capabilities to underlying streaming systems. We describe our implementation of the Dhalion framework on top of Twitter Heron, as well as a number of policies that automatically reconfigure Heron topologies to meet throughput SLOs, scaling resource consumption up and down as needed. We experimentally evaluate our Dhalion policies in a cloud environment and demonstrate their effectiveness. We are in the process of open-sourcing our Dhalion policies as part of the Heron project.
High Speed Focus Control MEMS Mirror With Controlled Air Damping for Vital Microscopy

A high speed focus control microelectromechanical systems (MEMS) mirror with a step response time of 100 μsec and small-displacement bandwidth of 25 kHz is reported for a 3 mm diameter, electrostatically actuated SU-8 membrane mirror. The dominant effect limiting the mirror bandwidth is viscous air damping, and the innovation we describe is the use of a perforated counter-electrode backplate that facilitates air flow underneath the membrane. We have adopted a model, originally developed for a MEMS microphone, to engineer the damping characteristics and design the air hole patterns. Cryogenic deep silicon etching creates through-wafer perforations in the backplate, and fabricated devices achieve wide-bandwidth actuation. The design approach, fabrication process, and dynamic characterization of the MEMS mirrors are shown. Finally, the focus control mirror is used in a confocal microscope for fast axial focus scanning to provide x-z cross-sectioned in vivo images.
Repaire of Large Segmental Bone Defects by Marrow Stromal Cells Transplant with Demineralized Bone Matrix

The aim of this study was to determine the healing potential of large segmental bone defects using tissue-engineered constructs in a large animal model before it can be introduced into a clinical trial. Isolated Autologous marrow stromal cells (aMSCs) were cultured in vitro, then seeded into allogenic demineralized bone matrix (aDBM) and co-cultivated for 7 days to construct DBM-MSCs complex. 24 goats were randomly divided into three groups (8 in each), on which 3 cm diaphyseal femoral defects were created unilaterally and subsequently filled with the DBM-MSCs complex, DBM alone and untreated control, respectively. A semiquantitative grading score was applied for radiological analysis after 12 weeks and 24 weeks. DBM-MSCs group increased the radiological scoring and biomechanical strength significantly and superiored over DBM only group. The animals in DBM-MSCs group total bone regeneration was observed in X-ray, whereas most of animal of DBM only group showed partial bone regeneration, while untreated showed no defect healing. Bone regeneration of DBM-MSCs group was histologically better than in DBM only controls and failed in untreated group. In summary, this study confirmed that the goat critical size defect was appropriate in size to produce large defect nonunions model, and our results strongly encourage the application of the transplantation of bone marrow stromal cells within demineralized bone matrix for bone regeneration of large segmental bone defects.
Acid‐sensing ion channels in trigeminal ganglion neurons innervating the orofacial region contribute to orofacial inflammatory pain

Orofacial pain is a common clinical symptom that is accompanied by tooth pain, migraine and gingivitis. Accumulating evidence suggests that acid‐sensing ion channels (ASICs), especially ASIC3, can profoundly affect the physiological properties of nociception in peripheral sensory neurons. The aim of this study is to examine the contribution of ASICs in trigeminal ganglion (TG) neurons to orofacial inflammatory pain. A Western blot (WB), immunofluorescence assay of labelled trigeminal ganglion neurons, orofacial formalin test, cell preparation and electrophysiological experiments are performed. This study demonstrated that ASIC1, ASIC2a and ASIC3 are highly expressed in TG neurons innervating the orofacial region of rats. The amplitude of ASIC currents in these neurons increased 119.72% (for ASIC1‐like current) and 230.59% (for ASIC3‐like current) in the formalin‐induced orofacial inflammatory pain model. In addition, WB and immunofluorescence assay demonstrated a significantly augmented expression of ASICs in orofacial TG neurons during orofacial inflammation compared with the control group. The relative protein density of ASIC1, ASIC2a and ASIC3 also increased 58.82 ± 8.92%, 45.30 ± 11.42% and 55.32 ± 14.71%, respectively, compared with the control group. Furthermore, pharmacological blockade of ASICs and genetic deletion of ASIC1 attenuated the inflammation response. These findings indicate that peripheral inflammation can induce the upregulation of ASICs in TG neurons, causing orofacial inflammatory pain. Additionally, the specific inhibitor of ASICs may have a significant analgesic effect on orofacial inflammatory pain.
CS 224 N Assignment 4 : Reading Comprehension

Building question answering systems with deep learning is a signiﬁcant application of solving the complex natural language problem of reading comprehension. In our approach, we have analyzed literature on previous work, implemented and improved on speciﬁc models described, and compared the various models to analyze the eﬀects of certain aspects of models on performance on the question answering task
WCET-Directed Dynamic Scratchpad Memory Allocation of Data

Many embedded systems feature processors coupled with a small and fast scratchpad memory. To the difference with caches, allocation of data to scratchpad memory must be handled by software. The major gain is to enhance the predictability of memory accesses latencies. A compile-time dynamic allocation approach enables eviction and placement of data to the scratchpad memory at runtime. Previous dynamic scratchpad memory allocation approaches aimed to reduce average-case program execution time or the energy consumption due to memory accesses. For real-time systems, worst-case execution time is the main metric to optimize. In this paper, we propose a WCET-directed algorithm to dynamically allocate static data and stack data of a program to scratchpad memory. The granularity of placement of memory transfers (e.g. on function, basic block boundaries) is discussed from the perspective of its computation complexity and the quality of allocation.
Investigating meaning construal in the language of the blind: a cognitive linguistic perspective

This paper describes and discusses issues pertaining to investigating meaning construal in the language of the blind. It introduces key problems in this largely unexplored area and proposes possible avenues of research by outlining four studies conducted over a period of eight years. The central arguments are built around the fundamental cognitive linguistic premise that language is an experiential phenomenon intimately related to general cognitive processes. The author focuses on the role of salience (or attention) and demonstrates how it is coded in the language of the blind. The main part of the paper starts with the outline of two exploratory studies the aim of which was to identify possible differences in salience and situatedness. The author discusses the contribution of the two studies and proceeds by describing a more focused study whose hypotheses were motivated by some of the questions raised in the previous two studies. The primary research question was related to the idea of the primacy of space in the blinds’ mental imagery and meaning construal. Finally, the author proposes a model integrating key language internal and language external factors affecting the process of meaning construal in this extraordinary population, and finishes by describing the fourth study whose primary aim was to double– test the research instrument used to investigate spatial (topological) elements in the language of the blind.
Evaluation in Discourse: a Corpus-Based Study

This paper describes the CASOAR corpus, the first manually annotated corpus that explores the impact of discourse structure on sentiment analysis with a study of movie reviews in French and in English as well as letters to the editor in French. While annotating opinions at the expression, the sentence or the document level is a well-established task and relatively straightforward, discourse annotation remains diffcult, especially for non experts. Therefore, combining both annotations poses several methodological problems that we address here. We propose a multi-layered annotation scheme that includes: the complete discourse structure according to the Segmented Discourse Representation Theory, the opinion orientation of elementary discourse units and opinion expressions, and their associated features. We detail each layer, explore the interactions between them and discuss our results. In particular, we examine the correlation between discourse and semantic category of opinion expressions, the impact of discourse relations on both subjectivity and polarity analysis and the impact of discourse on the determination of the overall opinion of a document. Our results demonstrate that discourse is an important cue for sentiment analysis, at least for the corpus genres we have studied.
Predictive Role of Thymidylate Synthase, Dihydropyrimidine Dehydrogenase and Thymidine Phosphorylase Expression in Colorectal Cancer Patients Receiving Adjuvant 5-Fluorouracil

Objective: The combined assessment of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) gene expressions in metastatic colorectal cancer has been reported to be able to predict the efficacy of fluoropyrimidine-based chemotherapy. In order to evaluate the prognostic role in the adjuvant setting, we investigated the TS, DPD and TP expression in primary tumors of colorectal cancer patients treated with 5-fluorouracil (5-FU). Methods: TS, DPD and TP expression levels were determined by immunohistochemistry in paraffin-embedded primary tumor tissues from 62 patients with Dukes’ stage B and C colorectal cancers who underwent surgery and received adjuvant systemic chemotherapy with 5-FU. The median follow-up was 90 months (range 17–127). Results: Dukes’ stage C cancer and high TS expression were independent markers of poor prognosis for disease-free survival (DFS; p = 0.0009 and p = 0.007, respectively) and overall survival (OS; p = 0.0005 and p = 0.011, respectively). By multivariate analysis, patients with high DPD expression had significantly shorter DFS (p = 0.007) and OS (p = 0.005) compared to patients with low DPD expression. In the combined analysis of 2 markers, patients with low TS and low DPD had the best outcome in terms of DFS (p = 0.007) and OS (p = 0.03). The analysis of all 3 proteins showed that the patients with low expression of all 3 markers had significantly longer DFS (p = 0.04) and OS (p = 0.01) than patients with a high value of any one of the protein expressions. However, the joint analysis of 3 markers (group with TS–/DPD–/TP–) could not identify a subgroup of patients with a better prognosis compared to the analysis of 2 markers (group with TS–/DPD–). The analysis of Dukes’ stage C cancer patients confirmed a significant benefit in terms of DFS and OS (p = 0.001 and p = 0.006, respectively) when all 3 markers had low expression. We also found a positive significant correlation between TS and TP protein expression (p = 0.033). Conclusions: This retrospective investigation suggests that the combined assessment of TS and DPD may be useful to evaluate the prognosis of patients with Dukes’ B and C colon carcinoma receiving 5-FU adjuvant chemotherapy. The role of TP as a predictor for 5-FU-based therapy needs further investigations.