Miracle-dz/UniFAR-FTUs huggingface dataset:
Translation of Dose Coefficients From ICRP 53 to ICRP 80

AbstractThe effective dose coefficients tabulated in Publication 80 of the International Commission on Radiological Protection (ICRP) for the radiopharmaceuticals addressed earlier in ICRP Publication 53 are based on the tissue weighting factors of ICRP Publication 60. Presumably these values are derived from the tissue dose coefficients tabulated in Publication 53; however, no details regarding their derivation are provided. The tissue weighting factors of Publication 60 explicitly address tissue for which no dose coefficients were tabulated in Publication 53; for example, esophagus and a number of tissues comprising the remainder. In the absence of guidance, the authors have defined a set of rules for the translation and have undertaken an effort to derive the effective dose coefficients of Publication 80 starting with the organ/tissue dose coefficient of Publication 53.
Crystallization and preliminary crystallographic study of human lithostathine

Crystals of human lithostathine, a pancreatic glycoprotein which inhibits the growth and nucleation of calcium carbonate crystals, were grown using PEG 4000 as the precipitating agent. The crystals belong to the hexagonal space group P61 (or its enantiomorph P65) and diffract to 1.55 Å resolution. There is one molecule in the asymmetric unit and the crystals have 39% solvent. © 1995 Wiley‐Liss, Inc.
Information, Privacy and Stability in Adaptive Data Analysis

Traditional statistical theory assumes that the analysis to be performed on a given data set is selected independently of the data themselves. This assumption breaks downs when data are re-used across analyses and the analysis to be performed at a given stage depends on the results of earlier stages. Such dependency can arise when the same data are used by several scientific studies, or when a single analysis consists of multiple stages. How can we draw statistically valid conclusions when data are re-used? This is the focus of a recent and active line of work. At a high level, these results show that limiting the information revealed by earlier stages of analysis controls the bias introduced in later stages by adaptivity. Here we review some known results in this area and highlight the role of information-theoretic concepts, notably several one-shot notions of mutual information.
Adaptive Energy-Aware Scheduling of Dynamic Event Analytics Across Edge and Cloud Resources

The growing deployment of sensors as part of Internet of Things (IoT) is generating thousands of event streams. Complex Event Processing (CEP) queries offer a useful paradigm for rapid decision-making over such data sources. While often centralized in the Cloud, the deployment of capable edge devices on the field motivates the need for cooperative event analytics that span Edge and Cloud computing. Here, we identify a novel problem of query placement on edge and Cloud resources for dynamically arriving and departing analytic dataflows. We define this as an optimization problem to minimize the total makespan for all event analytics, while meeting energy and compute constraints of the resources. We propose 4 adaptive heuristics and 3 rebalancing strategies for such dynamic dataflows, and validate them using detailed simulations for 100 - 1000 edge devices and VMs. The results show that our heuristics offer O(seconds) planning time, give a valid and high quality solution in all cases, and reduce the number of query migrations. Furthermore, rebalance strategies when applied in these heuristics have significantly reduced the makespan by around 20 - 25%.
Evolution in the Treatment of Sinonasal Inverted Papilloma: Pedicle-Oriented Endoscopic Surgery

Background In the literature, the global endoscopic sinus surgery (ESS) success in the treatment of sinonasal inverted papilloma (IP) is 95%. This study was designed to describe a conservative endoscopic approach, based on research of the tumor's pedicle and treatment concentrated on its site of attachment, and to compare the results of this technique with the outcome of standard endoscopic treatment. Methods Retrospective analysis of the patients treated in our institution for paranasal inverted papilloma (IP), between 2002 and 2011 with a minimum of 18 months follow-up was performed. Group A received a standard ESS including whole sinus demucosization (maxillary, ethmoid, frontal, or sphenoid sinus) and bony wall drilling. Group B patients instead underwent pedicle-oriented endoscopic surgery (POES); in this group, bony demucosization and drilling were selectively conducted around the site of pedicle attachment of the tumor. Results The cohort included 73 patients (median age, 60.5 years; median follow-up, 58 months). Group A/group B consisted of 37/36 patients. IP persistence—recurrence for group A/group B was 0/1 cases. Oncological success for global endoscopic/group A/group B was 98.6% (72/73)/100% (37/37)/97.2% (35/36). We noticed a significant difference in surgical operative time and postoperative complication rate among the groups, in favor of POES technique. Conclusion Our data confirm the efficacy of the endonasal endoscopic treatment for sinonasal IP. Moreover, the even more conservative endoscopic treatment proposed (POES) seems to offer good control of the disease, shorter operating times, avoidance of unnecessary surgery with respect to uninvolved structures, and permits a follow-up aimed at the site of the pedicle attachment.
Pharmacogenetic assessment of toxicity and outcome in patients with metastatic colorectal cancer treated with LV5FU2, FOLFOX, and FOLFIRI: FFCD 2000-05.

PURPOSE The aim was to investigate whether germline polymorphisms within candidate genes known or suspected to be involved in fluorouracil (FU), oxaliplatin, and irinotecan pathways were associated with toxicity and clinical outcome in patients with metastatic colorectal cancer (mCRC). PATIENTS AND METHODS Blood samples from 349 patients included in the Fédération Francophone de Cancérologie Digestive 2000-05 randomized trial, which compared FU plus leucovorin (LV5FU2) followed by FU, leucovorin, and oxaliplatin (FOLFOX) followed by FU, leucovorin, and irinotecan (FOLFIRI; sequential arm) with FOLFOX followed by FOLFIRI (combination arm) in terms of progression-free survival (PFS) and overall survival, were collected. Twenty polymorphisms within the DPD, TS, MTHFR, ERCC1, ERCC2, GSTP1, GSTM1, GSTT1, and UGT1A1 genes were genotyped. RESULTS The ERCC2-K751QC allele was independently associated with an increased risk of FOLFOX-induced grade 3 or 4 hematologic toxicity (P = .01). In the sequential arm, TS-5'UTR3RG and GSTT1 alleles were independently associated with response to LV5FU2 (P = .009) and FOLFOX (P = .01), respectively. The effect of oxaliplatin on tumor response increased with the number of MTHFR-1298C alleles (test for trend, P = .008). The PFS benefit from first-line FOLFOX was restricted to patients with 2R/2R (hazard ratio [HR] = 0.39; 95% CI, 0.23 to 0.68) or 2R/3R (HR = 0.59; 95% CI, 0.42 to 0.82) TS-5'UTR genotypes, respectively. Conversely, patients with the TS-5'UTR 3R/3R genotype did not seem to benefit from the adjunction of oxaliplatin (HR = 0.96; 95% CI, 0.66 to 1.40; trend between the three HRs, P = .006). CONCLUSION A pharmacogenetic approach may be a useful strategy for personalizing and optimizing chemotherapy in mCRC patients and deserves confirmation in additional prospective studies.
Influence of lipid/peptide hydrophobic mismatch on the thickness of diacylphosphatidylcholine bilayers. A 2H NMR and ESR study using designed transmembrane alpha-helical peptides and gramicidin A.

We have investigated the effect of a series of hydrophobic polypeptides (WALP peptides) on the mean hydrophobic thickness of (chain-perdeuterated) phosphatidylcholines (PCs) with different acyl chain length, using 2H NMR and ESR techniques. The WALP peptides are uncharged and consist of a sequence with variable length of alternating leucine and alanine, flanked on both sides by two tryptophans, and with the N- and C-termini blocked, e.g., FmAW2(LA)nW2AEtn. 2H NMR measurements showed that the shortest peptide with a total length of 16 amino acids (WALP16) causes an increase of 0.6 A in bilayer thickness in di-C12-PC, a smaller increase in di-C14-PC, no effect in di-C16-PC, and a decrease of 0.4 A in di-C18-PC, which was the largest decrease observed in any of the peptide/lipid systems. The longest peptide, WALP19, in di-C12-PC caused the largest increase in thickness of the series (+1.4 A), which decreased again for longer lipids toward di-C18-PC, in which no effect was noticed. WALP17 displayed an influence intermediate between that of WALP16 and WALP19. Altogether, incorporation of the WALP peptides was found to result in small but very systematic changes in bilayer thickness and area per lipid molecule, depending on the difference in hydrophobic length between the peptide and the lipid bilayer in the liquid-crystalline phase. ESR measurements with spin-labeled lipid probes confirmed this result. Because thickness is expected to be influenced most at the lipids directly adjacent to the peptides, also the maximal adaptation of these first-shell lipids was estimated. The calculation was based on the assumption that there is little or no aggregation of the WALP peptides, as was supported by ESR, and that lipid exchange is rapid on the 2H NMR time scale. It was found that even the maximal possible changes in first-shell lipid length were relatively small and represented only a partial response to mismatch. The synthetic WALP peptides are structurally related to the gramicidin channel, which was therefore used for comparison. In most lipid systems, gramicidin proved to be a stronger perturber of bilayer thickness than WALP19, although its length should approximate that of the shorter WALP16. The effects of gramicidin and WALP peptides on bilayer thickness were evaluated with respect to previous 31P NMR studies on the effects of these peptides on macroscopic lipid phase behavior. Both approaches indicate that, in addition to the effective hydrophobic length, also the physical nature of the peptide surface is a modulator of lipid order.
Discrete Binomial Splines

Abstract Analytic B-splines are important tools in different areas of signal processing. The present work introduces the discrete binomial splines which are born from analytic B-splines by bilinear transformation. The characteristics of the discrete binomial splines are compared with the directly sampled B-splines. The discrete binomial splines have approximately Gaussian-shaped frequency characteristics. They are fast to implement since minor number of multiplications are needed. A parallel combination of discrete binomial splines can be used to construct, e.g., discrete-time filters, kernels for wavelet transform, and multiresolution decomposition algorithms applied in image coding and interpolation.
Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity

A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymphocytes, and induces a G2/M phase cell cycle shift. Structural characterization of the natural product revealed the compound to be a 40-membered macrolactone with nine hydroxyl functional groups and a rare tert-butyl carbinol residue.
The Haemophilus influenzae dprABC genes constitute a competence-inducible operon that requires the product of the tfoX (sxy) gene for transcriptional activation

We previously showed that dprA is required for efficient processing of linear DNA during cellular transformation in Haemophilus influenzae. In this study the transcriptional regulation of dprA and two downstream genes, dprB and dprC, is examined. We demonstrate by Northern blot analysis that the dprABC genes are transcriptionally coregulated and competence inducible. We used primer extension analysis to map the transcriptional start site of dprA and of rec-2, another transformation gene involved in DNA processing. Based upon these results, we were able to identify a 26-bp dyad symmetry element immediately upstream of the -35 regions of the predicted promoters of dprA, rec-2, and two other transformation genes, comA and pilA. Finally, using transcriptional fusions of dprA to the Escherichia coli lacZ gene, we show that expression of dprA::lacZ requires tfoX and that the presence of multiple copies of tfoX abolishes the temporal regulation of dprA, resulting in its constitutive expression.
Three-Dimensional Characterization of Cryogenic Target Ice Layers Using Multiple Shadowgraph Views

Abstract Backlit optical shadowgraphy is the primary diagnostic for D2 ice layer characterization of cryogenic targets for the OMEGA Laser System at the Laboratory for Laser Energetics (LLE). Reflection and refraction of light passing through the ice layer produce characteristic rings. The position of the most prominent of the shadowgraph rings, known as the bright ring, can be resolved to ∼0.1-pixel rms, corresponding to about 0.12 μm for typical LLE target shadowgraphs. Measurement of the bright ring position in conjunction with ray-trace model predictions determines the ice layer thickness and the Fourier-mode spectrum of the ice roughness for that view. The LLE target characterization stations use two camera angles and target rotation to record target shadowgraphs from many different views. Combining these views allows construction of a 3-D ice layer representation, an estimation of the global surface roughness, and a determination of a Legendre-mode spectrum suitable for implosion modeling. The standard operating procedure is to construct a 3-D ice layer representation using the analysis of 48 separate shadowgraphic views. The 3-D ice surface is then decomposed in terms of spherical harmonics, allowing the determination of low-mode number (ℓ ≤ to 10) elements of a Legendre-mode power spectrum. Higher-mode number elements of the Legendre power spectrum are determined by mapping the Fourier-mode power spectrum averaged over all views
Board Game Prototyping to Co-Design a Better Location-Based Digital Game

In this case study we describe the iterative process of paper prototyping, using a board game, to co-design a location-based mobile application. The end goal of the application is to motivate reflection on historical topics about migration. The board game serves to capture the core concerns of this application by simulating movement through the city. Three play tests highlighted the users' interest and issues with the historical content, the way this content is represented, and the players' responses to the interactions and motivating mechanisms of the application. Results show that the board game helped capture important design preferences and problems, ensuring the improvement of our scenario. This feedback can help reduce development effort and implement a future technology prototype closer to the needs of our end users.
[Factor analysis of health related quality of life in patients admitted to a short stay medical unit].

BACKGROUND Disease and hospital admission have a great impact on the quality of life of an individual. AIM To identify the factors associated with health related quality of life (HRQL) in patients admitted to a Short Stay Medical Unit (SSMU). PATIENTS AND METHODS Prospective cohort study of 335 patients aged 15 to 99 years (196 males) consecutively admitted to the SSMU. In all we recorded sociodemographic data, number of previous hospital admissions, admission type, main diagnosis, lenght of stay, comorbidities, the Goldberg Depression and Anxiety Scale, the Karnofsky Perfomance Scale, the Barthel Index and quality of life with the EuroQol-5D instrument. After studying the associations between variables, we carried out a factor analysis of those that were significantly related to HRQL. RESULTS Mean body mass index was 27.7 Kg/m(2) and 83% were emergency admissions. Heart failure, chronic obstructive pulmonary disease exacerbation, acute coronary syndromes and cardiac arrhythmias, constituted 56% of all admissions. HRQL was statistically related to age, gender, educational status, caregiving situation, number of previous admissions, main diagnosis, length of stay, Goldberg scale and Karnofsky, Barthel and Charlson indexes. Factor analysis reduced the original variables to five, which explained 67.8% of the variance, as follows: Factor 1- Karnofsky and Barthel indexes (27.8%); Factor 2- age, educational status, caregiving situation (12.3%); Factor 3- the Goldberg scale (10.4%); Factor 4- admission type (8.8%); Factor 5- main diagnosis (8.4%). CONCLUSIONS HRQL in patients admitted to Short Stay Medical Unit is partially related to perfomance status, age, social and psychological status, admission type an the main diagnosis.
Medication supply in closed loop medication - conceptual understanding and prerequisites

Closed loop medication (CLM) is an electronic supported medication management process. In addition to reducing errors, the approach provides better documentation, better traceability and better support for evaluating efficacy. Commonly today, medication information is registered in many standalone systems and manual transfer between these represents a risk of human error. To be able to discuss the CLM concept, a shared understanding is needed. In this paper, a definition of CLM is suggested and the concept is elaborated regarding prerequisites and dependencies. The definition of CLM was discussed in meetings with stakeholders regionally. Sales data from the hospital pharmacy in Trondheim (July–December 2016) were reviewed with respect to possible inclusion in a CLM. Dependencies, e.g. pharmaceutical formulation and suitability regarding repackaging into identifiable unit doses, was considered. The following definition of CLM is suggested: ‘CLM is an electronically supported process for medication management where information from ordering to the point of administration is transferred seamlessly between different systems. Documentation during the process is done electronically and traceable. The CLM follows the single medication unit’. At St. Olav’s hospital in the city of Trondheim, Norway, the local unit dose system repackages tablets, capsules, suppositories, ampoules, vials and more. The weekly output is about 45 000 units. Approximately 60% of total sales may be identifiable at the point of administration. For tablets and capsules, the number is about 80%. Only 14% of the medications are available as identifiable unit doses from the industry. These numbers strongly indicate that in order to reach the CLM ambitions, systems for repackaging of medications are needed.
APPLICATILITY OF THE VISCERAL ADIPOSITY INDEX (VAI) IN THE PREDICTION OF THE COMPONENTS OF THE METABOLIC SYNDROME IN ELDERLY.

UNLABELLED The nutritional assessment may detect a state of malnutrition, overweight and cardiometabolic risk in the elderly. Easy to apply instruments enable the identification of risk factors for cardiovascular diseases (CVD). OBJECTIVE to analyze the applicability of Visceral Adiposity Index (VAI) in the prediction of MS components in the elderly. METHODS cross-sectional study with 221 elderly at a mean age of 70.65 ± 7.34 years; 53.4% female and 46.4% male. Weight, height, waist circumference (WC), fasting glucose, triglycerides (TG), total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), and blood pressure (BP), data was obtained, as well as information about lifestyle. There were calculated the Body Mass Index (BMI), the Waist-Hip Ratio (WHR), and the VAI. The adiposity measures were compared with the components of MS, and for the VAI there was determined the capability of predicting the occurrence of MS components. RESULTS by analyzing the association among the biochemical and pressoric variables and MS components with the anthropometric indicators of obesity, there was a direct and significant correlation of the BMI, the weight and the VAI with blood glucose, HDL and TG (p.
Hamiltonian studies of the d =2 Ashkin-Teller model

We study a one-dimensional quantum Hamiltonian problem which is equivalent to a highly anisotropic version of the two-dimensional Ashkin-Teller model. This problem is studied by using its duality and other symmetry properties, by a consideration of its limiting cases, and by mapping it into an XXZ linear chain which is equivalent to a highly anisotropic six-vertex model. In addition eleventh-order strong-coupling series are used to derive numerical data about the Hamiltonian problem. By these means a phase diagram is obtained. The essentially new feature of this diagram is a "critical fan, " i.e., a region where a line of continuously varying criticality "fans out" and becomes an area of critical behavior.
On lossy compression of binary matrices

We consider lossy compression of random binary matrices under distortion constraints that strive to preserve the structure of the matrix. Specifically, we assume that matrix elements are statistically independent (but not necessarily identically distributed), and that the worst case row/column average distortion is to be controlled. We discuss a natural notion of matrix types termed (R, c)-type, and provide various results concerning its probability and cardinality, as well as a “Sanov-type” result, in the spirit of the method-of-types. We then derive bounds on the associated matrix ratedistortion function via a suitable matrix version of the covering lemma.
A High Quality Software after Maintenance Depend on Effectiveness measures

Providing high quality software after maintenance is one of the most important topics, especially in long-term projects or an open source projects. In this paper we measure the quality of software after maintenance based on quality in use main measure effectiveness which has three measures task completion, task effectiveness and error frequency. This paper present an approach to extract developer experience where the experience of developer is a main factor that help to improving the maintenance process We analyzed these measures to the extent of their contribution in the achievement of high quality after maintenance tasks.
Oblivious Equilibrium with Dominant Firms

In a recent paper, Weintraub, Benkard, and Van Roy (2008b) propose an approximation method for analyzing Ericson and Pakes (1995)-style dynamic models of imperfect competition. In that paper, we defined a new notion of equilibrium, oblivious equilibrium (henceforth, OE), in which each firm is assumed to make decisions based only on its own state and knowledge of the long run average industry state, but where firms ignore current information about competitors’ states. The great advantage of OE is that they are much easier to compute than are Markov perfect equilibria (henceforth, MPE). Moreover, we showed that an OE provides meaningful approximations of long-run Markov perfect dynamics of an industry with many firms if, alongside some technical requirements, the equilibrium distribution of firm states obeys a light-tail condition. To facilitate using OE in practice, in Weintraub, Benkard, and Van Roy (2008a) we provide a computational algorithm for solving for OE, and approximation bounds that can be computed to provide researchers with a numerical measure of how close OE is to MPE in their particular application. We also provided computational evidence supporting the conclusion that OE often yields good approximations of MPE behavior for industries like those that empirical researchers would like to study. While our computational results suggest that OE will be useful in many applications on its own, we believe that a major contribution of OE will be as a starting point with which to build even better approximations. As a matter of fact, in Weintraub, Benkard, and Van Roy (2008a) we extend our base model as well as algorithms for computing OE and error bounds to incorporate aggregate shocks common to all firms. Such an extension is important, for example, when analyzing the dynamic effects of industry-wide business cycles.