Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhancement of RANKL‐induced MITF‐E expression and osteoclastogenesis by TGF‐β

Microphthalmia‐associated transcription factor (MITF) is a transcription factor that is expressed in limited types of cells, including osteoclasts, but the expression and role of MITF during osteoclastogenesis have not been fully elucidated. The expression of the MITF‐E isoform but not that of the MITF‐A isoform was induced in response to differentiation stimulation towards osteoclasts by receptor activator of NF‐κB ligand (RANKL) in both RAW264.7 cells and primary bone marrow cells. The RANKL‐induced formation of tartrate‐resistant acid phosphatase (TRAP)‐positive multinucleated cells was inhibited in RAW264.7 cells expressing siRNA for MITF‐E. Transforming growth factor‐β (TGF‐β) enhanced RANKL‐induced MITF‐E expression and ‐TRAP positive multinucleated cell formation. In particular, TGF‐β potentiated the formation of larger osteoclasts. The expression levels of NFATc1, TRAP and CtsK, genes related to osteoclast development and activity, were concurrently enhanced by TGF‐β in the presence of RANKL. Furthermore, the expression of dendritic cell‐specific transmembrane protein (DC‐STAMP), Itgav, Itga2, Itga5, Itgb1, Itgb3 and Itgb5, genes related to cell adhesion and fusion, were up‐regulated by co‐treatment with TGF‐β. In particular, the regulatory expression of Itgav and Itgb5 in response to RANKL with or without TGF‐β resembled that of MITF‐E. Because MITF is involved in cell fusion in some cell systems, these results imply a role for MITF‐E as an enhancer of osteoclastogenesis and that RANKL‐induced levels of both MITF‐E mRNA and of MITF‐dependent gene expression are enhanced by treatment with TGF‐β. Copyright © 2014 John Wiley & Sons, Ltd.
A Research on Increasing Context Perception in Online Communication

Web forum was a fully developed, cheap and popular medium to support online communication. But most of the web forums still followed the basic Table View interface inherited from the antique Bulletin Board System (BBS). The rigid interface limited context perception by users. To avoid troubles of software developing, many web service providers choose free package (such as the Discuz! ) to deploy their web sites, which furthermore enhanced the homogeneity of page views. Tree View forum was one of the possible rescues. A Tree View forum provided richer context information than traditional Table View. But there were only a few web sites successfully adopted Tree View. To answer the question why Tree View was better in conveying context information but less popular, a Web View Generator (WVG) was devised to support Table View and Tree View, as well as other potential web-page view patterns. Furthermore, research was conducted to test users’ perception and understanding of the contents of web pages in both Tree View and Table View. It was found that Tree View web pages presented the context of discussion better than Table View web pages. The barrier in preventing the popularization of the Tree View related to the inexperience with the Tree View. Tree View was also found to be more reading-time saving than Table View. KeywordsOnline communication; Context perception; Tree View; web forum; SNS; Interaction
Southeast Asian Foot-and-Mouth Disease Viruses in Eastern Asia

Foot-and-mouth disease (FMD) outbreaks recently affected 2 countries (Japan and South Korea) in eastern Asia that were free of FMD without vaccination. Analysis of viral protein 1 nucleotide sequences indicated that FMD serotype A and O viruses that caused these outbreaks originated in mainland Southeast Asia to which these viruses are endemic.
Low-Voltage AC Drive Based on Double-Sided Cooled IGBT Press-Pack Modules

We present a feasibility study of low-voltage drives based on double-sided cooled power modules. A novel press-pack module was developed, and an inverter was built up subsequently. The drive was benchmarked with a 400-kW ac industrial inverter. A significant increase in the current density and output power was achieved.
Estimation of contribution of multiple scattering into the optical coherence tomography signal from layers of different biological tissues

Optical coherence tomography (OCT) signals from blood layers (thickness of 0.5 mm) for the haematocrits of 35, 10 and 5%, intralipid (thickness of 2 mm) for 10, 5 and 2% concentrations, as well as from upper skin layers (stratum corneum and epidermis) for the thicknesses of 120, 135 and 150 jim were simulated using Monte-Carlo method. For blood and intralipid simulations the wavelength was chosen equal to 820 nm and for upper skin layers simulation equal to 630 nm. The coherence length was assumed to be 15 Iim. The contribution of multiple scattering to OCT was analyzed for the models under study. It was shown that for blood the percentage ofmultiple scattering contribution in to the signal increases as haematocrit goes up: for 5%-haematocrit the contribution is less than 1%, for 10%-haematocrit about 4.5%, and for 35% - some 64%. It appears that for intralipid the major contribution to the signal for all the concentrations under consideration is made by multiple scattering: for 2%-concentration - about 44.5%, for 5%-concentration -72%, and for 10%-concentration - more than 85%. Apparently, for skin surface layers the multiple scattering contribution rises as the layer thickness increases: as the layer thickness is varied from 20 to 50 im the multiple scattering contribution varies from 14 to 74%.
A 0.5V 1KS/s 2.5nW 8.52-ENOB 6.8fJ/conversion-step SAR ADC for biomedical applications

A low-FOM SAR ADC using the leakage reduction bootstrapped switch (LRBS) to achieve a satisfactory ENOB and using a low-power approach with a low voltage, low sampling rate, and low-DAC-capacitance structure is presented for biomedical applications. LRBS is proposed to alleviate the leakage caused by the low-power approach to increase SNDR and ENOB. From the measurement results, the 0. 18µm CMOS prototype chip with the total DAC capacitance of 2.765pF consumes 2.5nW and achieves a SNDR of 53.05dB under a 0.5V supply voltage at 1KS/s with a Nyquist input. The resulting FOM is 6.8fJ/conversion-step.
Tangible design support system using RFID technology

We introduce a tangible design support system using RFID technology. This system allows users to design their houses on their own through tangible objects. Building a new house is a big project for many people, and everyone dreams about freely designing their own house. However, in general, it is difficult to realize this without architectural knowledge and a high level of computing skills. Our system employs tangible user interfaces for a user who has limited or no knowledge to design a new house and investigate the design. For example, the user can design room layout by paving the design table with special tiles and customize the room's properties such as wall, floor, or even furniture by placing miniatures on the table. Through this design process, the user can identify crucial design elements based on their preferences and make the right decision as well as allow an architect to understand the user's preferences.
Code generation for a coarse-grained reconfigurable architecture

—Good tool support is essential for computing platforms because they increase programmability. This is especially the case for reconﬁgurable architectures because applications need to be mapped on the architecture for each conﬁguration individually. This paper introduces a compiler backend for Coarse Grained Reconﬁgurable Arrays (CGRA) based on LLVM. The CGRA compiler must be retargetable to support all possible architecture conﬁgurations. Instruction scheduling is done using an operation based list scheduling algorithm which uses a resource graph. The scheduler uses an improved version of Dijkstra’s algorithm for ﬁnding operand paths. Energy efﬁciency is taken into account by using the explicit bypassing capabilities of the hardware. The number of register ﬁle operations is decreased by 23% on average.
Inria+Xerox@FGcomp: Boosting the Fisher vector for fine-grained classification

This report describes the joint submission of Inria and Xerox to their participation to the FGCOMP 2013 challenge. Although the proposed system follows most of the standard Fisher classification pipeline, we describe several key features and good practices that improve the accuracy when specifically considering fine-grained classification tasks. In particular, we consider the late fusion of two systems both based on Fisher vectors, but that employ drastically different design choices that make them very complementary. Moreover, we show that a simple yet effective filtering strategy significantly boosts the performance for several class domains.
On enhancing searching for information in an information portal by tracking users' activities

Although some of the existing approaches forenhancing searching for information in an informationportal account for some aspects of users' behaviour in theportal, a more systematic treatment of this issue is needed,foremost the role of the content and the structure of aportal on the analysis of usage information. In this paper,we first present the analysis of the factors which theefficient searching depends on and based on it, we proposethe conceptual architecture of the management componentfor an information portal. We assume that the informationportal is built around a common taxonomy (in our case anontology), which is an emerging trend in knowledgemanagement applications we are particularly interesetedin. The management component ensures that searching forinformation will include all factors which determine therelevance of an information resource, enabling the top-rankingof the highly relevant information resources. Theapproach is mainly based on tracking users' interactionswith the portal. We have applied the approach in theinformation portal of our Institute and an evaluation studyis presented.
Intraoperative parathyroid hormone measurement in patients with secondary hyperparathyroidism.

HYPOTHESIS Secondary hyperparathyroidism decreases renal clearance of parathyroid hormone (PTH). OBJECTIVE To determine whether rapid PTH assays can be used to predict the success of a total parathyroidectomy to treat symptomatic secondary hyperparathyroidism. DESIGN Case series from August 1 to December 31, 2000. SETTING Tertiary referral center. PARTICIPANTS Patients with symptomatic secondary hyperparathyroidism (n = 24) who underwent total parathyroidectomy and autotransplantation were included in the study. INTERVENTIONS Blood samples for rapid PTH analyses were drawn from an indwelling catheter at the induction of anesthesia (baseline) and before (0 minutes), 10 minutes, and 30 minutes after the removal of the last parathyroid gland. Regular intact PTH (iPTH) assays were conducted later. MAIN OUTCOME MEASURE If a patient's regular iPTH levels were below 65 pg/mL at 1 week or 3 months postoperatively, the operation was considered successful. RESULTS All 24 patients had successful operations. Rapid PTH and regular iPTH correlated significantly at 0, 10, and 30 minutes. Rapid PTH levels decreased significantly at each time period and were 176 +/- 40.9 pg/mL (mean +/- SE) at 10 minutes. The percentage decrease in rapid PTH levels was 39.5% +/- 12.7% at 0 minutes, 75.1% +/- 6.2% at 10 minutes, and 91.0% +/- 0.1% at 30 minutes (mean +/- SE). A decrease of 60% or more from baseline PTH levels at 10 minutes and/or a decrease of 85% or more at 30 minutes predicted the successful removal of all parathyroid glands. CONCLUSIONS A drop in PTH levels is delayed until 30 minutes after total parathyroidectomy; however, a rapid PTH assay 10 minutes after the removal of the last parathyroid gland is as accurate as an assay performed at 30 minutes postoperatively. Intraoperative PTH monitoring demonstrates relevant decreases in rapid PTH levels after parathyroidectomy that are similar to those previously documented in patients with primary hyperparathyroidism.
A modified fixed sphere decoding algorithm for under-determined MIMO systems

A modified FSD algorithm is proposed for under-determined (UD) multiple-input multiple-output (MIMO) systems with N transmit antennas and M < N receive antennas. This paper focuses on the low-complexity detection of coded UD-MIMO systems with iterative turbo detection, where a soft-input soft-output (SISO) MIMO detector exchanges soft information with a SISO decoder. In the first iteration, a modified fixed complexity sphere decoding (FSD) method is developed by utilizing the structure of a UD-MIMO system. The modified FSD employs a new detection ordering scheme that has a lower complexity but a better performance compared to the conventional ordering scheme. From the second iteration and beyond, the MIMO detector is implemented with a generalized serial interference cancelation (GSIC) scheme and a block decision feedback equalizer (BDFE) to further reduce the complexity. Simulation results show that the newly proposed FSD-GSIC-BDFE structure can achieve significant performance gains over existing schemes, especially for systems with high level modulations.
Preliminary exploratory data analysis of simulated national clinical data research network for future use in annotation of a rare tumor biobanking initiative

Observational data resources based on the capture of clinical data in the electronic health record (EHR) have produced significant learning opportunities in many areas of medicine. These large data resources can span multiple hospital systems and employ common semantics, ontologies, and data models. They have uncovered critical safety issues for patients, and spurred observational research and clinical decision support. In the age of precision medicine there is also an increased need to obtain genomic and clinical data to discover novel treatments for the deadliest of diseases. With this, there are efforts to create deep-dive disease specific repositories that include tissue in biobanks. The latter require significant human annotation of biospecimens. Securing the data is especially critical in rare pediatric brain tumors. In the specific case of The Children's Brain Tumor Tissue Consortium (CBTTC) an international rare pediatric brain tumor repository, the number of patients that need to be followed prospectively is outpacing the ability of human annotation. In this preliminary study, we perform a prescribed data exploration analysis on simulation data in the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) employed by the pediatric data network PEDSNet with the intention to ascertain feasibility in automatic annotation of patient records in the CBTTC.
Mathematical Models of the Impact of IL2 Modulation Therapies on T Cell Dynamics

Several reports in the literature have drawn a complex picture of the effect of treatments aiming to modulate IL2 activity in vivo. They seem to promote either immunity or tolerance, probably depending on the specific context, dose, and timing of their application. Such complexity might derive from the pleiotropic role of IL2 in T cell dynamics. To theoretically address the latter possibility, our group has developed several mathematical models for Helper, Regulatory, and Memory T cell population dynamics, which account for most well-known facts concerning their relationship with IL2. We have simulated the effect of several types of therapies, including the injection of: IL2; antibodies anti-IL2; IL2/anti-IL2 immune-complexes; and mutant variants of IL2. We studied the qualitative and quantitative conditions of dose and timing for these treatments which allow them to potentiate either immunity or tolerance. Our results provide reasonable explanations for the existent pre-clinical and clinical data, predict some novel treatments, and further provide interesting practical guidelines to optimize the future application of these types of treatments.
Lamb Wave-Based Damage Location Detection Method of Composite Plate

To understand more about Lamb waves on composite laminates damage detection features, the Lamb wave group velocity dispersion curves are calculated and plotted by using dichotomy method in MATLAB. The signal parameters are chosen according to Group velocity dispersion curves. The dynamic response signals of the composite plate are obtained by finite element method. Damage location is calculated by the actual group velocity of Lamb wave and time of flight of the difference signal before and after damage.
Engineering and Modeling Carbon Nanofiller-Based Scaffolds for Tissue Regeneration

iii ACKNOWLEDGMENTS . vii LIST OF FIGURES . xii LIST OF TABLES . xvii LIST OF ABBREVIATIONS AND NOTATIONS . xviii CHAPTER I LITERATURE REVIEW . 1 Background . 1 1. Tissue Engineering. 1 2. Skin Grafts and Organ Transplants . 3 Introduction . 4 1. Tissue Scaffolds . 5 1.1. Hard Scaffolds . 9 1.2. Soft Scaffolds . 11 2. Materials Approach to Improved Scaffold . 12 2.1 Biopolymer and Compatible Polymers. 12 2.1.1. Compatibility . 18 2.1.2. Structural Properties . 19 3. Conductive Scaffolds . 20 3.1. Conductive Polymers Approach . 21 3.1.1. Polypyrrole (PPy) . 23 3.1.2. Polyaniline (PANI) . 25 3.1. 3. Polythiophene (PTh) . 26 3.1. 4. Blend Polymers . 27 3.2. Carbon Additives Approach . 32 3.2.1 Conductivity. 38 3.2. 2. Surface Properties . 40 3.2. 3. Cell Viability . 46 3.2. 4. Durability . 47
Notes on the Use of Plan Structures in the Creation of Interactive Plot

An interactive system defines a virtual space, whether the system’s interface provides access to the inhospitable planet of Stroggos or the Microsoft Windows desktop. Users of both these systems interact with a place, one created by a computer and in which users and computational agents carry out their individual and collective activities. The intuitive and often-discussed benefit of a well-designed interface metaphor is that it allows users to carry over conventions from their "real" experience when performing tasks within the interface world. Another key and often unarticulated value of an interface arises from the interface’s mimetic quality. While mimesis is often discussed by narrative theorists as a contrast to diegesis, distinguishing the concepts of showing versus telling (Aristotle), my emphasis here is to distinguish between an artifact that is intended to be an imitation of something, but is not really that thing and an artifact that is intended to be mistaken as that thing. An example of the former case would be a film of a fictional account of the D-Day landing on the beaches of Normandy. An example of the later might be a virtual reality system displaying photo-realistic graphical images of a physical space. D-Day stories like The Longest Day and Saving Private Ryan are, in some ways, imitations, and so are more mimetic than VR systems whose design is intended to ". produce synthetic images visually and measurably indistinguishable from real world images. " (Greenberg 1999)(pg. 45). The interface to a virtual space presents an abstracted, artificial representation of a world and the activities within it; it is the mimetic character of the space, together with our understanding that we are interacting with a mimetic artiflcat, that allows us as users to bring to bear all our knowledge of narrative understanding during our interaction (Brannigan 1992). When a user enters into a such a virtual space, it is as if a narrative contract is established between the user and the system’s authors. 1 The contract establishes
Influence of Heat Treatment on Structure and Properties of the Cast Magnesium Alloys

In this paper is presented the structure and proprieties of the cast magnesium alloys as cast state and after heat treatment cooled with different cooling rate, depending on the cooling medium (furnace, water, air). For investigations samples in shape of 250x150x25 mm plates were used. The presented results concern X-ray qualitative and quantitative microanalysis as well as qualitative and quantitative X-ray diffraction method, tensile tests, hardness measurement. In the analysed alloys a structure of α %solid solution and fragile phase β (Mg17Al12) occurred mainly on grain borders as well as eutectic and phase AlMnFe, Mg2Si. Investigation are carried out for the reason of chemical composition influence and precipitation processes influence to the structure and mechanical properties of the magnesium cast alloys with different chemical composition in as cast alloys and after heat treatment.
Anticachectic Effects of Formoterol

In cancer cachexia both cardiac and skeletal muscle suffer an important protein mobilization as a result of increased proteolysis. Administration of the β2-agonist formoterol to both rats and mice bearing highly cachectic tumors resulted in an important reversal of the muscle-wasting process. The anti-wasting effects of the drug were based on both an activation of the rate of protein synthesis and an inhibition of the rate of muscle proteolysis. Northern blot analysis revealed that formoterol treatment resulted in a decrease in the mRNA content of ubiquitin and proteasome subunits in gastrocnemius muscles; this, together with the decreased proteasome activity observed, suggest that the main anti-proteolytic action of the drug may be based on an inhibition of the ATP-ubiquitin-dependent proteolytic system. Interestingly, the β2-agonist was also able to diminish the increased rate of muscle apoptosis (measured as DNA laddering as well as caspase-3 activity) present in tumor-bearing animals. The present results indicate that formoterol exerted a selective, powerful protective action on heart and skeletal muscle by antagonizing the enhanced protein degradation that characterizes cancer cachexia, and it could be revealed as a potential therapeutic tool in pathologic states wherein muscle protein hypercatabolism is a critical feature such as cancer cachexia or other wasting diseases.
Compiler blockability of numerical algorithms

An attempt was made to determine whether a compiler can automatically restructure computations well enough to avoid the need for hand blocking. To that end, programs in LAPACK were studied for which it was possible to examine both the block version and the corresponding point algorithm. For each of these programs, it was determined whether a plausible compiler technology could succeed in obtaining the block version from the point algorithm. The results are encouraging: one can block triangular and trapezoidal loops, and many of the problems introduced by complex dependence patterns can be overcome by the use of the transformation known as index-set splitting. In addition, it was shown that knowledge about which operations commute can enable a compiler to succeed in blocking codes that could not be blocked by any compiler based strictly on dependence analysis. <<ETX>>