Miracle-dz/UniFAR-FTUs huggingface dataset:
Spatially Resolved Chandra Imaging Spectroscopy of the Classical/Weak-Lined T Tauri System V710 Tau

We present spatially resolved X-ray observations of the binary T Tauri star system V710 Tau. Using Chandra’s Advanced CCD Imaging Spectrometer (ACIS), we imaged this 3.2″ separation binary system, consisting of a classical T Tauri star, V710 Tau N, and a weak-lined T Tauri star, V710 Tau S. The Chandra ACIS-S3 images—obtained in two 9 ks exposures separated by about 3 months (2004 December and 2005 April)—cleanly resolve the V710 Tau binary, demonstrating that both stars emit X-rays, and thereby enabling the first spectral/temporal study of the individual components of this mixed (classical and weak-lined) T Tauri star binary system. The northern component, V710 Tau N, appears to have been in a flaring state during the first (2004 December) exposure. During this flare event, the X-ray flux of the classical T Tauri star hardened significantly. Single-component plasma models with plasma temperatures in the range kTX ∼ 0.7–1.1 keV are adequate to fit the observed X-ray spectra of V710 Tau S in 2004 December and both stars in 2005 April. The 2004 December flare-state observation of V710 Tau N requires a higher temperature plasma component (kTX ∼ 2.5–3.0 keV) in addition to the soft component (kTX ∼ 0.5 keV), and is better fit by a model that includes a slightly enhanced Ne/Fe abundance ratio. These results are generally consistent with statistical contrasts between the X-ray emission properties of classical (rapidly accreting) versus weak-lined (weakly accreting or nonaccreting) T Tauri stars.
Genetic Deletion of Akt3 Induces an Endophenotype Reminiscent of Psychiatric Manifestations in Mice

The protein kinase B (PKB/Akt), found in three distinctive isoforms (PKBα/Akt1, PKBβ/Akt2, PKBγ/Akt3), is implicated in a variety of cellular processes such as cell development, growth and survival. Although Akt3 is the most expressed isoform in the brain, its role in cerebral functions is still unclear. In the present study, we investigated the behavioral, electrophysiological and biochemical consequences of Akt3 deletion in mice. Motor abilities, spatial navigation, recognition memory and LTP are intact in the Akt3 knockout (KO) mice. However, the prepulse inhibition, three-chamber social, forced swim, tail suspension, open field, elevated plus maze and light-dark transition tests revealed an endophenotype reminiscent of psychiatric manifestations such as schizophrenia, anxiety and depression. Biochemical investigations revealed that Akt3 deletion was associated with reduced levels of phosphorylated GSK3α/β at serine 21/9 in several brain regions, although Akt1 and Akt2 levels were unaffected. Notably, chronic administration of lithium, a mood stabilizer, restored the decreased phosphorylated GSK3α/β levels and rescued the depressive and anxiety-like behaviors in the Akt3 KO mice. Collectively, our data suggest that Akt3 might be a critical molecule underlying psychiatric-related behaviors in mice.
Anatomic Evidence of a Three-Dimensional Mosaic Pattern of Tonotopic Organization in the Ventral Complex of the Lateral Lemniscus in Cat

The ventral complex of the lateral lemniscus (VCLL, i.e., the ventral and intermediate nuclei) is composed of cells embedded in the fibers of the lateral lemniscus. These cells are involved in the processing of monaural information and receive input from the collaterals of the fibers ascending to the inferior colliculus. Whereas tonotopic organization is a feature of all other nuclei of the auditory system, this functional principle is debated in the VCLL. We have made focal injections of the tracer biotinylated dextran amine into different frequency band representations of the inferior colliculus in cat. Retrogradely labeled cells and terminal fibers (collaterals of efferent local axons and other ascending lemniscal fibers) were found in the ipsilateral VCLL. The spatial distribution of the labeling was analyzed using three-dimensional (3-D) reconstruction and computer graphical visualization techniques. A complex topographic organization was found. In all cases, labeled fibers and cells were distributed in multiple clusters throughout the dorsoventral extent of the VCLL. The shape, size, and location of the labeled clusters suggest an interdigitation of clusters assigned to different frequency-band representations. But an overall mediolateral distribution gradient was observed, with high frequencies represented medially and lower frequencies progressively more laterally. We conclude that the clusters may represent discontinuous frequency-band compartments as a counterpart to the continuous laminar compartments in the remaining auditory nuclei. The 3-D orderly mosaic pattern indicates that the VCLL preserves the spectral decomposition originated in the cochlea in a way that facilitates across-frequency integration.
Give2Get: Forwarding in Social Mobile Wireless Networks of Selfish Individuals

In this paper we present two forwarding protocols for mobile wireless networks of selfish individuals. We assume that all the nodes are selfish and show formally that both protocols are Nash equilibria, that is, no individual has an interest to deviate. Extensive simulations with real traces show that our protocols introduce an extremely small overhead in terms of delay, while the techniques we introduce to force faithful behavior have the positive side-effect to improve performance by reducing the number of message considerably (more than 20\%). We test our protocols also in the presence of a natural variation of the notion of selfishness—nodes that are selfish with outsiders and faithful with people from the same community. Even in this case, our protocols are shown to be very efficient in detecting possible misbehavior.
Nonnegative Matrix Factorization with Earth Mover's Distance Metric for Image Analysis

Nonnegative matrix factorization (NMF) approximates a given data matrix as a product of two low-rank nonnegative matrices, usually by minimizing the L2 or the KL distance between the data matrix and the matrix product. This factorization was shown to be useful for several important computer vision applications. We propose here two new NMF algorithms that minimize the Earth mover's distance (EMD) error between the data and the matrix product. The algorithms (EMD NMF and bilateral EMD NMF) are iterative and based on linear programming methods. We prove their convergence, discuss their numerical difficulties, and propose efficient approximations. Naturally, the matrices obtained with EMD NMF are different from those obtained with L2-NMF. We discuss these differences in the context of two challenging computer vision tasks, texture classification and face recognition, perform actual NMF-based image segmentation for the first time, and demonstrate the advantages of the new methods with common benchmarks.
Immunity based virus detection with process call arguments and user feedback

Detecting unknown virus is a challenging task. Most of the current virus detection approaches, such as anti-virus tools, require precognition of virus signatures for detection, but they are hard to detect unknown virus. In this paper, we present a new immunity based virus detection approach. This approach collects arguments of process calls instead of the sequence of process, which obtain more information of process, and then utilizes them to train detectors with real-valued negative selection (RVNS) algorithm. In the stage of testing, user feedback is analyzed to adjust the threshold between normal files and viruses. We took two experiments to evaluate the performance of the approach, and the detection rate achieved is 0.7, which proved this approach could cope with unknown virus.
Catalytic water dissociation by greigite Fe3S4 surfaces: density functional theory study

The iron sulfide mineral greigite, Fe3S4, has shown promising capability as a hydrogenating catalyst, in particular in the reduction of carbon dioxide to produce small organic molecules under mild conditions. We employed density functional theory calculations to investigate the {001},{011} and {111} surfaces of this iron thiospinel material, as well as the production of hydrogen ad-atoms from the dissociation of water molecules on the surfaces. We systematically analysed the adsorption geometries and the electronic structure of both bare and hydroxylated surfaces. The sulfide surfaces presented a higher flexibility than the isomorphic oxide magnetite, Fe3O4, allowing perpendicular movement of the cations above or below the top atomic sulfur layer. We considered both molecular and dissociative water adsorption processes, and have shown that molecular adsorption is the predominant state on these surfaces from both a thermodynamic and kinetic point of view. We considered a second molecule of water which stabilizes the system mainly by H-bonds, although the dissociation process remains thermodynamically unfavourable. We noted, however, synergistic adsorption effects on the Fe3S4{001} owing to the presence of hydroxyl groups. We concluded that, in contrast to Fe3O4, molecular adsorption of water is clearly preferred on greigite surfaces.
School-level correlates of physical activity intensity in 10-year-old children.

PURPOSE Little is known about school environmental factors that promote or inhibit activity, especially from studies using objective measures in large representative samples. We therefore aimed to study associations between activity intensities and physical and social school environmental factors. METHODS A population-based sample of 1 908 British children (SPEEDY study), mean age 10.3 years (Standard deviation [SD]: 0.3), recruited from 92 schools across Norfolk, UK, with valid activity data (assessed with Actigraph accelerometers). Outcome measures were school-based (8 am-4 pm on weekdays) time (in minutes) spent in sedentary (<100 counts/min), moderate (2 000-3 999 counts/min) and vigorous (≥4 000 counts/min) activity. A total of 40 school physical and social environmental factors were assessed. Multivariable multilevel linear regression analyses adjusted for children's sex and body mass index were conducted; interactions with sex were investigated. RESULTS Availability of a 'Park and Stride' scheme was negatively associated with sedentary minutes (-7.74; 95% CI: -14.8; -0.70). Minutes of moderate activity were associated with the availability of a lollypop person (1.33, 95% CI: 0.35; 2.62) and objectively-assessed walking provision (1.70, 95% CI: 0.85; 2.56). The number of sports facilities of at least medium quality (0.47, 95% CI: 0.16; 0.79), not having a policy on physical activity (-2.28, 95% CI: -3.62; -0.95), and, in boys only, provision of pedestrian training (1.89; 95% CI: 0.77; 3.01) were associated with minutes of vigorous activity. CONCLUSIONS Only a small number of school-level factors were associated with children's objectively-measured physical activity intensity, giving few pointers for potential future intervention efforts. Further research should focus on using objective measures to elucidate what factors may explain the school-level variance in activity levels.
Role of Autonomic Nervous System in the Pathogenesis of Prinzmetal's Variant Form of Angina

In ten patients with Prinzmetal's variant form of angina the effects of various drugs were assessed: subcutaneous injection of methacholine (10 mg), atropine (0.7 mg), and epinephrine (0.7 mg); intravenous infusion of isoproterenol (20-25 &mgr;g/min); and in the three of the above patients who were having recurrent spontaneous attacks at the time of the examination, oral administration of atropine (0.6-1.2 mg), propranolol (30-90 mg), and phenoxybenzamine (10 mg in one patient). Master's triple two-step test and selective coronary arteriography were done on all the patients.In the three patients who were having spontaneous attacks at the time of the examination, the administration of methacholine induced the attacks and that of atropine suppressed the attacks. Epinephrine induced the attacks in two patients and propranolol was without effect in suppressing the attacks. Phenoxybenzamine (in one patient) suppressed the attacks. Neither Master's triple two-step test nor isoproterenol infusion precipitated the attacks, though heart rate increased to more than 110 beats/min and 160 beats/min respectively in all the patients. Coronary arteriograms were normal in seven of the ten patients.It is concluded that enhanced activity of the parasympathetic nervous system, which occurs at rest, is involved in the initiation of the attack by stimulating the sympathetic nerve which in turn probably induces coronary arterial spasm by way of activating alpha (vasoconstrictor) receptors present in the large coronary arteries.
Epidemiological characteristics of Chinese paediatric traumatic brain injury inpatients

ABSTRACT Primary objective: To investigate the epidemiological characteristics of paediatric inpatients with traumatic brain injury (TBI) in China. Research design: The Chinese Trauma Database (CTD), a nationwide register system based on hospital admission data, contains diagnosis and treatment information for trauma inpatients in over 200 military-managed public-service hospitals in China. Using the ICD-9 coding, the data for children with TBI aged 0–17 years between 2001 and 2007 were retrieved. Methods and procedures: The demographic characteristics, admission time, injury cause, severity and treatment outcomes of paediatric inpatients with TBI were analysed. Main outcomes and results: A total of 26,028 paediatric inpatients with TBI (69.52% male, 30.48% female) were included in the CTD. Motor vehicle traffic (MVT) accidents, falls and assaults were the primary causes of injury. Falls were the leading cause of TBI in children aged 0–4 years, and MVT was the leading cause of TBI in children aged 5–17 years. According to the abbreviated injury scale, 37.20% of the TBI cases were mild, 25.15% were moderate, 24.81% were severe and 12.84% were critically severe. Conclusion: Chinese authorities should develop targeted measures to reduce children injuries based on the leading causes of TBI in the different age groups, particularly MVT, falls and assaults.
Variable Microsatellite Markers for Genotyping Tree Shrews, Tupaia, and their Potential Use in Genetic Studies of Fragmented Populations

We describe the sequences of six primer pairs for the PCR amplification of nuclear microsatellite markers in the tree shrews, Tupaia glis and T. belangeri. Multilocus genotyping based on non-destructive DNA sampling of live-trapped animals reveals high allelic variability (A) and heterozygosity (He) at these loci. Such characteristics make these genetic markers ideal for linkage mapping and comparative genomics, and for studies of pedigree relationships, population structure, and population genetic variability in wild populations. We illustrate another use of these markers in the study of genetic erosion in small recently fragmented natural populations of tree shrews in south Thailand. This method for detecting and monitoring genetic erosion in fragmented populations can be applied to larger taxa of traditional concern to wildlife managers.
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

Endoplasmic reticulum (ER) stress sensors use a related luminal domain to monitor the unfolded protein load and convey the signal to downstream effectors, signaling an unfolded protein response (UPR) that maintains compartment-specific protein folding homeostasis. Surprisingly, perturbation of cellular lipid composition also activates the UPR, with important consequences in obesity and diabetes. However, it is unclear if direct sensing of the lipid perturbation contributes to UPR activation. We found that mutant mammalian ER stress sensors, IRE1α and PERK, lacking their luminal unfolded protein stress-sensing domain, nonetheless retained responsiveness to increased lipid saturation. Lipid saturation-mediated activation in cells required an ER-spanning transmembrane domain and was positively regulated in vitro by acyl-chain saturation in reconstituted liposomes. These observations suggest that direct sensing of the lipid composition of the ER membrane contributes to the UPR.
ANT COLONY OPTIMIZATION TO SHUNT CAPACITOR ALLOCATION IN RADIAL DISTRIBUTION SYSTEMS

SUMMARY This paper presents an ant colony approach optimization to shunt capacitor placement on distribution systems under capacitor switching constraints. The optimum capacitor allocation solution is found for the system of feeders fed through their transformer and not for any individual feeder. The main advantages due to capacitor installation, such as system capacity release and reduction of overall power and energy losses are considered. The capacitor allocation constraints due to capacitor-switching transients are taken into account. These constraints are extremely important if pole-mounted capacitors are used together with a station capacitor bank. An ant colony algorithm is used as an optimization tool. An illustrative example for Algerian network is presented.
Genetic risk factors for serious infections in inflammatory bowel diseases

Abstract Introduction: Immunosuppression, the cornerstone of management of Crohn’s disease (CD) and ulcerative colitis (UC) (inflammatory bowel diseases; IBD) is associated with an increased risk of serious infections that is inadequately predicted by clinical risk factors. The role of genetics in determining susceptibility to infections is unknown. Methods: From a prospective-consented patient registry, we identified IBD patients with serious infections requiring hospitalization. Analysis was performed to identify IBD-related and non-IBD related immune response loci on the Immunochip that were associated with serious infections and a genetic risk score (GRS) representing the cumulative burden of the identified single nucleotide polymorphisms was calculated. Multivariable logistic regression used to identify effect of clinical and genetic factors. Results: The study included 1333 IBD patients (795 CD, 538 UC) with median disease duration of 13 years. A total of 133 patients (10%) had a serious infection requiring hospitalization. Patients with infections were more likely to have CD and had shorter disease duration. The most common infections were skin and soft-tissue, respiratory and urinary tract infections. Eight IBD risk loci and two other polymorphisms were significantly associations with serious infections. Each one point increase in the infection GRS was associated with a 50% increase in risk of infections (OR = 1.53, 95% CI = 1.37–1.70) (p = 1 × 10−14), confirmed on multivariable analysis. Genetic risk factors improved performance of a model predicting infections over clinical covariates alone (p < 0.001). Conclusions: Genetic risk factors may predict susceptibility to infections in patients with IBD.
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

Significance Two types of ubiquitin chain are required to switch on one of the major signaling networks of the innate immune system that triggers the production of inflammatory mediators to combat infection by pathogens. This paper reports the unexpected discovery that both types of ubiquitin chain are attached covalently to one another and that the formation of one type of ubiquitin chain is dependent on the prior formation of the other. One function of these hybrid ubiquitin chains is to permit the colocalization of two different kinase complexes, thereby facilitating the activation of one kinase complex by the other to increase the speed of the response to infection. Polyubiquitin (pUb) chains formed between the C terminus of ubiquitin and lysine 63 (K63) or methionine 1 (M1) of another ubiquitin have been implicated in the activation of the canonical IκB kinase (IKK) complex. Here, we demonstrate that nearly all of the M1-pUb chains formed in response to interleukin-1, or the Toll-Like Receptors 1/2 agonist Pam3CSK4, are covalently attached to K63-pUb chains either directly as K63-pUb/M1-pUb hybrids or indirectly by attachment to the same protein. Interleukin-1 receptor (IL-1R)-associated kinase (IRAK) 1 is modified first by K63-pUb chains to which M1-pUb linkages are added subsequently, and myeloid differentiation primary response gene 88 (MyD88) and IRAK4 are also modified by both K63-pUb and M1-pUb chains. We show that the heme-oxidized IRP2 ubiquitin ligase 1 interacting protein (HOIP) component of the linear ubiquitin assembly complex catalyzes the formation of M1-pUb chains in response to interleukin-1, that the formation of K63-pUb chains is a prerequisite for the formation of M1-pUb chains, and that HOIP interacts with K63-pUb but not M1-pUb linkages. These findings identify K63-Ub oligomers as a major substrate of HOIP in cells where the MyD88-dependent signaling network is activated. The TGF-beta–activated kinase 1 (TAK1)-binding protein (TAB) 2 and TAB3 components of the TAK1 complex and the NFκB Essential Modifier (NEMO) component of the canonical IKK complex bind to K63-pUb chains and M1-pUb chains, respectively. The formation of K63/M1-pUb hybrids may therefore provide an elegant mechanism for colocalizing both complexes to the same pUb chain, facilitating the TAK1-catalyzed activation of IKKα and IKKβ. Our study may help to resolve the debate about the relative importance of K63-pUb and M1-pUb chains in activating the canonical IKK complex.
COLLABORATION WITH TANGIBLE AUGMENTED REALITY INTERFACES

We describe a design approach, Tangible Augmented Reality, for developing interfaces for supporting face-to-face collaboration. By combining Augmented Reality techniques with Tangible User Interface elements, we can create interfaces in which users can interact with spatial data as easy as real objects. Tangible AR interfaces remove the separation between the real and virtual worlds and so enhance natural face-to-face communication. We describe several prototype applications showing how this design approach can be applied in practice.