Miracle-dz/UniFAR-FTUs huggingface dataset:
Gene organization around the phenylalanyl-transfer ribonucleic acid synthetase locus in Escherichia coli

The organization of seven genes located at about 38 min on the genetic map of Escherichia coli was examined; these genes included pheS and pheT, which code for the alpha and beta subunits of phenylalanyl-transfer ribonucleic acid synthetase, and thrS, the structural gene for threonyl-transfer ribonucleic acid synthetase. Deletion mutants were isolated from an F-prime-containing merodiploid strain and were characterized genetically. Seventeen different kinds of deletions extending into pheS of pheT were identified. These deletions unambiguously defined the gene order as aroD pps himA pheT pheS thrS pfkB. Mutants with deletions covering either pheS or pheT, but not both, were analyzed further by assay of phenylalanyl-transfer ribonucleic acid synthetase. The phenotype of the mutants with a deletion from pfkB through pheS was anomalous; although the pheT gene was apparently still present, its product, the beta subunit, was much reduced in activity.
Understanding of Modern Movement in Kayseri By Using Oral History Methods: A Case on Akdamar Apartment, 1960’s

In the recent history of the modernization of dwelling and housing culture, much attention has been given to oral history methodology. However, less research has been done on 1960’s houses and very little on actual homeowners’ firsthand experiences in their homes in Kayseri, Turkey. For this reason, this study attempts to use oral history as a way to critically understand how the modern home was built and how residents lived in the space in the 1960’s. In this context, the Akdamar Family Apartment is assumed to provide a large corpus of data, documenting the living, subjective, social, cultural, and dialectical experiences of a modern home during the 1960’s by utilizing oral history methods. To verify this hypothesis, interviews with Akdamar Family members have been utilized, and the physical space of the Akdamar house has been reconstructed and analyzed. In addition to this reconstruction, a floorplan and various photographs are used to demonstrate the actual family life lived within that space in those years. By using the data gathered from oral history methodology performed with the Akdamar Family, it is possible to examine how the family as individuals used their home during this period as well as the relationship between the space they inhabited and their domestic needs in order to understand the 1960’s modern house movement. This case study has also recorded stories about various aspects of historic neighborhoods, including architectural features and the alteration of Republic-era houses in Kayseri. As a result, this paper attempts to demonstrate that the way in which oral history stories are constructed tends to destabilize the notion of 1960’s architectural intention.
Market Frictions and the Efficiency of Capital Allocation

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Cellular functions during activation and damage by pathogens: Immunogold studies of the interaction of bacterial endotoxins with target cells

Bacterial endotoxins (lipopolysaccharides or LPS) are active components of Gramnegative bacteria that act on numerous cellular functions through the processes of cell activation and damage. The molecular mechanisms involved in the “endotoxic phenomenon” are not defined yet, although extensive studies have been carried out. Immunogold and electron microscopy (EM) have contributed to identify the primary target cells of endotoxins and the subcellular systems that receive the direct action of these bacterial agents. Here, we review our studies on immunogold detection of endotoxins in cellular and subcellular systems. The analysis of the interaction between endotoxins and cells was focussed on the following aspects: (1) morphological characteristics of the LPS aqueous suspensions used in experimental work; (2) binding of endotoxins to the plasma membrane of type II pneumocytes and alveolar macrophages (two of their cellular targets), and influence of the state of aggregation of the LPS; (3) movement and distribution of endotoxins inside the cell, from the plasma membrane to the nucleoplasm; and (4) interaction of LPS with microtubules and its effects on the integrity of the microtubular network. These approaches provide information at the molecular level as well as data for the establishment of physiological models of endotoxicity. © 1995 Wiley‐Liss, Inc.
New CNB measures to stimulate credit growth: problems and solutions

The paper analyses the new measure implemented by Croatian national bank (CNB). The measure is a decrease in the reserve requirement, but the actual release of funds is contingent on increase in lending to firms. This new measure is significant because for the first time in Croatia there is a measure whose purpose is to affect specifically credit policy of the banks. Although this new measure has good intentions it does not solve the problem of why highly liquid banking system in Croatia is not willing to increase lending. The reason for lack of credit growth lies in two separate problems. The first problem is the willingness of banks to have more credit risk and the second problem is the way monetary policy is conducted in Croatia.
Use of variable p(H) interface to a mass spectrometer for the measurement of dissolved volatile compounds.

A wide variety of dissolved chemicals can be measured continuously with some specificity by directly interfacing a relatively inexpensive mass spectrometer to a solution. Specifically, we describe the construction and initial use of a membrane interace to a mass spectrometer which allows the continuous measurement of the concentration of dissolved volatile compounds in buffered aqueous solution. In addition to volatile compounds that do not dissociate appreciably at p(H) 7 (e.g., ethanol, ethylene glycol), volatile acids and bases, such as acetic acid or ammonia, can be measured with the interface is operated within the range 1</=p(H)</=12. We also discuss the sensitivity of the system to variations in flow rate and describe a satisfactory method for providing sufficiently constant flow rates.
Low cost microwave oscillator using substrate integrated waveguide cavity

A topology is proposed for designing a low-cost microwave oscillator. This new feedback oscillator makes use of a substrate integrated waveguide (SIW) cavity that acts as a frequency selector as well as a feedback-coupling device. The oscillator is stabilized by using an injection-locking scheme. A 12.02-GHz oscillator prototype was designed. Experimental results for phase noise, locking range, and quality factor of the new circuit are presented. An external Q of 178 was measured.
Insulin granule recruitment and exocytosis is dependent on p 110 γ in insulinoma and human β-cells Running Title : PI 3 kinase-γ Regulates Granule Localization

1 University of Alberta, Department of Pharmacology and the Alberta Diabetes Institute, Edmonton, Alberta, Canada 2 University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Headington, Oxford, United Kingdom 3 Merck Serono, Geneva Research Center, Geneva, Switzerland 4 University of Toronto, Department of Medicine, Medical Biophysics, Institute of Medical Science, Ontario Cancer Institute, Toronto, Ontario, Canada.
Identifying the Worst Reliability Input Vectors and the Associated Critical Logic Gates

Scaling the CMOS devices deep into the nanorange reduces their reliability margins significantly. Consequently, accurately calculating the reliability of digital nanocircuits is becoming a necessity for investigating design alternatives to optimize the trade-offs between area-power-delay and reliability. However, accurate reliability calculation of large and highly connected circuits is complex and very time consuming. This paper proposes a progressive consensus-based algorithm for identifying the worst reliability input vectors and the associated critical logic gates. Improving the reliability of the critical gates helps circuit designers to effectively improve the circuit overall reliability while having a minimal impact on the traditional power-area-deal design parameters. The accuracy and efficiency of the algorithm can be tuned to fit a variety of applications. The algorithm scales well with circuit size, and is independent of the interconnect complexity and the logic depth. Extensive computational results show that the accuracy and the efficiency of the proposed algorithm are better than the most recent results reported in the literature.
In vitro expression and pharmacology of the 5‐HT7‐like receptor present in the mosquito Aedes aegypti tracheolar cells and hindgut‐associated nerves

We have previously reported the cloning of a 5‐hydroxytryptamine receptor (Aedes 5‐HT7‐like receptor) from adult Aedes aegypti. For functional expression of the Aedes 5‐HT7‐like receptor, CHO‐K1 cells were stably transfected with a receptor expression construct, pC5‐HT7. The Aedes 5‐HT7‐like receptor positively coupled to Gs protein, increasing intracellular cAMP in response to 5‐HT; adenylyl cyclase activity was induced in a concentration‐dependent, saturable manner. Only 5‐HT, and not octopamine, dopamine or tyramine, caused the induction of cAMP. At 10 nm 5‐HT a weak synergism was observed between octopamine and 5‐HT. Other known agonists of the mammalian 5‐HT7 receptor were tested. Their order of potency was: 5‐HT >> 5‐CT = 8‐OH‐DPAT >> pimozide. This is the first report on the functional expression of a mosquito neurohormone receptor.
A computational approach to reconstructing gene regulatory networks

With the rapid accumulation of gene expression data in publicly accessible databases, computational study of gene regulation has become an obtainable goal Intrinsic to this task will be data mining tools for inferring knowledge from biological data. In this project, we have developed a new data mining technique in which we adapt the connectivity of a recurrent neural network model by indexing regulatory elements and including nonlinear interaction terms. The new technique reduces the number of parameters by O(n), therefore increasing the chance of recovering the underlying regulatory network. In order to fit the model from data, we have developed a genetic fitting algorithm with O(n) time complexity and that adapts the connectivity during the fitting process until a satisfactory fit is obtained. We have implemented this fitting algorithm and applied it to two data sets: rat central nervous system development (CNS) data with 112 genes, and yeast whole genome data with 2467 genes. With multiple runs of the fitting algorithm, we were able to efficiently generate a statistical pattern of the model parameters from the data. Because of its adaptive features, this method will be especially useful for reconstructing coarse-grained gene regulatory network from large scale or genome scale gene expression data sets.
Determinants of Short-Term Institutional Trading During Tranquil and Crisis Time

Using institutional trades across 36 countries for the period 2003-2008, this paper investigates the determinants of short-term institutional trading and how they differ across tranquil and crisis times at a weekly frequency. Before the financial crisis of 2007-2008, we find strong evidence of short-term momentum trading at both the stock and market levels. During the crisis, however, short-term momentum trading decreases significantly at both the stock and market levels, whereas medium-term momentum trading tends to increase. Further, during the crisis, institutions prefer to buy significantly larger, lower book-to-market, and higher turnover stocks than they did before the crisis.
Panel-Sized TFT-LCD Column Driver

Panel-sized TFT-LCD column drivers have been fabricated on a glass substrate with TF CMOS and low-resistivity copper-plated interconnections. These operate with a 16.25MHz internal clock, have 6b DACs, 6b accuracy with either 3072 or 1536 outputs, and use an offset-controlled amplifier. The operation of 15 inch XGA LCDs is demonstrated using panel-sized column drivers.
Assessment of dyeing properties and quality parameters of natural dye extracted from Lawsonia inermis

In India, traditionally some plants were used for dyeing the fabrics. According to dye yield and fastness properties the plant was chosen for fabric dyeing. Most of the synthetic dyes showed strong allergy and pollutant to the environment. So, for the current need we are chosen the plant Lawsonia inermis to colour the fabrics in this work. First, the dye was obtained through the extraction methods and studied the physicochemical properties of the dye. The dyeing properties were optimized for colouring the cotton and cotton thread. Different colour fastness parameters were also noted. In this work, we found the red dye obtained through alkaline extraction has better colour strength i.e. the maximum colour intensity at 3M NaOH. The peak at 1.907 from HPLC result confirmed the lawsone compound present in the dye. During dyeing the fabrics showed brighter colour after 24 hours. In fastness studies while washing with soap and dried under sunlight for a day and 2 days later, the colour was slightly faded in all fabrics. Still, due to its nontoxic and eco-friendly features the henna dye can be an effective natural dye for clothing.
A Content Analysis on Management Fashions in Turkish Manufacturing Companies

Recently many scholars have paid attention to the concept of management fashions as a new field in organization studies. This research aims to emphasize the awareness of organizations about management fashions and how strongly organizations adopt new management approaches. As a qualitative research a content analysis was applied. Data was obtained from web sites of 79 companies based on the first 500 businesses according to the data of Istanbul Chamber of Industry (2011) and also were listed in Exchange Istanbul’s Industrial index (XUSIN). The findings have shown that strategic management, HRM and TQM are practiced more than organizational learning, innovation and ethics/social responsibility. Theoretical and practical implications are also discussed.
Predicting Customer Churn at a Swedish CRM-system Company

This master thesis investigates if customer churn can be predicted at the Swedish CRM-system provider Lundalogik. Churn occurs when a customer leaves a company and is a relevant issue since it is cheaper to keep an existing customer than finding a new one. If churn can be predicted, the company can target their resources to those customers and hopefully keep them. Finding the customers likely to churn is done through mining Lundalogik's customer database to find patterns that results in churn. Customer attributes considered relevant for the analysis are collected and prepared for mining. In addition, new attributes are created from information in the database and added to the analysis. The data mining was performed with Microsoft SQL Server Data Tools in iterations, where the data was prepared differently in each iteration. The major conclusion from this thesis is that churn can be predicted at Lundalogik. The mining resulted in new insights regarding churn but also confirmed some of Lundalogik's existing theories regarding churn. There are many factors that needs to be taken into consideration when evaluating the results and which preparation gives the best results. To further improve the prediction there are some final recommendations, i.e. including invoice data, to Lundalogik of what can be done.
CDCR with buccal mucosal graft: comparative and histopathological study.

BACKGROUND AND OBJECTIVE Conjunctivodacryocystorhinostomy (CDCR) is a procedure with a high functional success rate, on the other hand post-operative complications are frequent and tube replacement is often required. Therefore, new investigations were undertaken in order to relieve the undesired effects of the tube. Implantation of the Jones tube circumscribed with a buccal mucosal graft and subsequent removal of the tube when an epithelium lined track was formed has been reported in the literature in recent years. In this study efficacy and safety of this alternative technique was evaluated. PATIENTS AND METHODS CDCR with insertion of Jones tube surrounded with a buccal mucosal graft was performed on 14 patients (14 eyes) between September 1995 and March 1997 and results were evaluated. Results were compared with our previous series of traditional CDCR, involving 22 patients (22 eyes). RESULTS Functional success was obtained in all cases with relief of epiphora after a mean follow-up of 13.7+/-5.7 months. In 11 cases, tubes were removed at the sixth post-operative month and passage was blocked in 9 cases. Subsequent surgical tube reinsertion was performed in those patients. Biopsy specimens were obtained in two cases during tube replacement and were examined histologically. Disarrangement of the basal epithelial cells and infiltration of the surrounding connective tissue with round cells were observed. These histopathological findings suggested a significant graft degeneration threatening the continuity of the passage. Tube displacement existed in two patients, and partial mucosal graft extrusion was apparent in one case during the period with the tube still inserted. Surgical tube replacement was required in only two cases to correct lateral migration of the tube. Incidence of complications and need for surgical tube replacement were found to be less than our previous series of 22 CDCR patients without buccal mucosa grafting. CONCLUSION These findings suggest that CDCR with buccal mucosal graft is a promising new method for the treatment of epiphora because of its low incidence of complications during the period with the tube. However, tube removal at the sixth post-operative month is probably not indicated. Therefore, studies with larger series and longer follow-up should be undertaken to confirm the advantages of the technique.
Modeling of LCC HVDC system based on mass-damping-spring concept

This paper presents a linearized model of a line-commutated converter-based HVDC system based on mass-damping-spring concept. The model takes the characteristics of converters, controllers and DC transmission line into consideration and represents the dynamic behavior of LCC HVDC system in the low frequency range. The developed model not only can be easily used for stability analysis with some linear analysis tools, such as classical modal analysis or frequency domain analysis tools, but also can be used to help researchers to intuitively understand and interpret the analysis or simulation results obtained from these classical analysis tools. What's more, it is convenient for the model to adopt mass-damping-spring concept to qualitatively and quantitatively measure LCC HVDC system, which makes it suitable for large system-level stability analysis studies. The model is validated by the CIGRE HVDC benchmark time-domain model in PSCAD/EMTDC.
Optimal Trade Execution with Coherent Dynamic Risk Measures

We study the problem of optimal trade execution in an illiquid market by minimizing the coherent dynamic risk of the implementation shortfall. The prices of the assets are modeled as a discrete-time Markov process perturbed by both temporal and permanent impacts related to the trading volume. A closed-form optimal strategy is obtained for liquidating a single asset. In the case of multiple assets, we show that the optimal execution problem is equivalent to a saddle-point problem, for which efficient first-order methods are utilized to compute the optimal strategy numerically.
Combining appropriability mechanisms for innovation collaboration by knowledge-intensive services firms

We explore the relation between the choice of value appropriability strategies mechanisms and that of innovation collaboration with different external organisations for knowledge-intensive business services (KIBS) firms. Our research paves the way for a better understanding of firm choices of appropriability strategy and innovation collaboration in sectors where formal appropriability mechanisms (such as patents) play a less important role in capturing value from innovation. Multivariate analyses - using data from an original survey of UK and US publicly-traded KIBS firms - indicate that KIBS firms do not consider formal appropriability mechanisms as significant value capture mechanisms for value capture. Despite thisHowever, there iswe find a positive association between the importance accorded to formal appropriability mechanisms (e.g. patents, copyrights, trademarks) and to innovation collaboration (especially with public research organisations). Nevertheless, a high levels of emphasis on formal appropriability mechanisms are is associated with assigning less importance to collaboration with clients. Contractual appropriability mechanisms (e.g. confidentiality agreements, employment contracts) are considered the most important appropriability mechanisms, but high levels of emphasis on these are associated with assigning less importance toof innovation collaboration (especially with clients). We also uncover associations between the combination of different appropriability mechanisms and the importance of innovation collaboration with (different) external organisations. We finally find that different combinations of appropriability mechanisms are associated with an enhanced or diminished collaboration capacity.
The Influence of Continuous Improvement Practices on Learning: An Empirical Study

Note: Review of this paper was conducted by Dr. James R. Evans, editor emeritus of the Quality Management Journal. This paper examines whether continuous improvement practices (CIPs) directly affect organizational improvement, or whether their impact on improvement is mediated by learning, which then leads to improved performance. A survey instrument was developed using both prior scales and new items. The collected responses were then analyzed using structural equation modeling techniques, which suggested that the maturity of a firm's use of CIPs fully mediated the effects of CIPs and learning on organizational improvement. These findings provide evidence that it is essential for a firm to create an organizational structure to support continuous improvement and to help make continuous improvement the way the firm does its work.
Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening

It is assumed that ATP induces closure of the binding jaw of ligand‐gated P2X receptors, which eventually results in the opening of the membrane channel and the flux of cations. Immobilization by cysteine mutagenesis of the binding jaw inhibited ATP‐induced current responses, but did not allow discrimination between disturbances of binding, gating, subunit assembly or trafficking to the plasma membrane.