Miracle-dz/UniFAR-FTUs huggingface dataset:
Author Name Disambiguation for PubMed

Log analysis shows that PubMed users frequently use author names in queries for retrieving scientific literature. However, author name ambiguity may lead to irrelevant retrieval results. To improve the PubMed user experience with author name queries, we designed an author name disambiguation system consisting of similarity estimation and agglomerative clustering. A machine‐learning method was employed to score the features for disambiguating a pair of papers with ambiguous names. These features enable the computation of pairwise similarity scores to estimate the probability of a pair of papers belonging to the same author, which drives an agglomerative clustering algorithm regulated by 2 factors: name compatibility and probability level. With transitivity violation correction, high precision author clustering is achieved by focusing on minimizing false‐positive pairing. Disambiguation performance is evaluated with manual verification of random samples of pairs from clustering results. When compared with a state‐of‐the‐art system, our evaluation shows that among all the pairs the lumping error rate drops from 10.1% to 2.2% for our system, while the splitting error rises from 1.8% to 7.7%. This results in an overall error rate of 9.9%, compared with 11.9% for the state‐of‐the‐art method. Other evaluations based on gold standard data also show the increase in accuracy of our clustering. We attribute the performance improvement to the machine‐learning method driven by a large‐scale training set and the clustering algorithm regulated by a name compatibility scheme preferring precision. With integration of the author name disambiguation system into the PubMed search engine, the overall click‐through‐rate of PubMed users on author name query results improved from 34.9% to 36.9%.
Intestinal plasma membrane calcium pump protein and its induction by 1,25(OH)2D3 decrease with age.

The plasma membrane Ca pump of intestinal absorptive cells has been proposed as a component in the vitamin D-dependent active transport of Ca. Because intestinal Ca transport declines with age, the purpose of this study was to determine if changes in Ca pump expression parallel this decline. Intestinal levels of the plasma membrane Ca pump protein were measured by Western blotting in Fischer 344 rats that were 2, 12, and 24 mo of age. Ca pump protein levels declined by 90% in the duodenum and 65% in the ileum between 2 and 12 mo of age, the time during which active Ca transport declines markedly. The effect of age on the induction of the Ca pump by 1,25-dihydroxyvitamin D3[1,25(OH)2D3], the active metabolite of vitamin D, was determined. Rats were made deficient in 1,25(OH)2D3 by feeding a high-strontium diet, and they were then dosed with 1,25(OH)2D3 or vehicle at 48, 24, and 6 h. In 12-mo-old rats 1,25(OH)2D3 induced duodenal Ca pump protein to only 39% and active Ca transport to 33% of that seen in 2-mo-old animals. These studies demonstrate that decreased expression of the plasma membrane Ca pump protein, along with calbindin protein, parallels the decline in intestinal Ca transport and its response to 1,25(OH)2D3 with age.
Cyclist exposure to the risk of car door collisions in mixed function activity centers: A study in Melbourne, Australia

ABSTRACT Objective: The objective of this study is to describe key risks related to dooring collisions on roads in mixed function activity centers by examining video footage recorded onboard the bicycles of cyclists riding through this road environment. The study aims to enhance our understanding of the risk associated with cyclist door collisions on these roads and to provide a focus for future studies that aim to identify measures that enhance cyclist safety. Method: The study measured 4 key risk exposures (per hour and kilometer), namely, on-street parked cars and 3 conditions associated with parked cars being accessed or egressed: door opened (a) after the cyclist passes (give-way event); (b) in the path of the cyclist without collision (obstruction event); and (c) in the path of the cyclist with collision (collision event). Exposure to the risk factors was measured using video footage recorded onboard the bicycles of adult cyclists (n = 25) as they rode through this road environment. The average speed of cyclists was also estimated from these video data and related to the measures of exposure. Results: The cycling experiences of the participants were observed over 3 h 58 min and 84.0 km. On average, the sample was exposed to 1,166 parked car events per hour (55 per kilometer), 6.9 give-way events per hour (0.3 per kilometer), 2.3 obstruction events per hour (0.1 per kilometer), and no collision events. There were 9 instances of obstruction events. In most cases, the cyclist was clearly visible (n = 7; 77.8%) and modified his or her position to avoid the door (n = 8; 88.9%). Moreover, the door was opened by the driver in nearly all cases (n = 8; 88.9%), primarily to exit the vehicle (n = 4; 44.4%) or enter the vehicle (n = 3; 33.3%). The average speed of cyclists was 22.7 km/h (SD = 4.1 km/h), and average speed tended to reduce as exposure to parked car events increased. Conclusion: Cyclists seldom interact with a vehicle occupant accessing or egressing a parked car, yet a concerning proportion of these interactions involve the occupant opening the door in the path of the cyclist, rather than waiting for the cyclist to pass. This suggests that there is still considerable need to identify measures that increase the likelihood that a vehicle occupant will look for cyclists before opening the car door, particularly in road environments where longer-term solutions such as physical separation are not readily achieved.
Complexity of middle cerebral artery blood flow velocity: effects of tilt and autonomic failure.

We examined spectral fractal characteristics of middle cerebral artery (MCA) mean blood flow velocity (MFV) and mean arterial blood pressure adjusted to the level of the brain (MAPbrain) during graded tilt (5 min supine, -10°, 10°, 30°, 60°, -10°, supine) in eight autonomic failure patients and age- and sex-matched controls. From supine to 60°, patients had a larger drop in MAPbrain (62 ± 4.7 vs. 23 ± 4.5 mmHg, P < 0.001; means ± SE) and MFV (16.4 ± 3.8 vs. 7.0 ± 2.5 cm/s, P < 0.001) than in controls. From supine to 60°, there was a trend toward a decrease in the slope of the fractal component (β) of MFV (MFV-β) in both the patients and the controls, but only the patients had a significant decrease in MFV-β (supine: patient = 2.21 ± 0.18, control = 1.99 ± 0.60; 60°: patient = 1.46 ± 0.24, control = 1.62 ± 0.19). The β value of MAPbrain(MAPbrain-β; 2.19 ± 0.05) was not significantly different between patients and controls and did not change with tilt. High and low degrees of regulatory complexity are indicated by values of β close to 1.0 and 2.0, respectively. The increase in fractal complexity of cerebral MFV in the patients with tilt suggests an increase in the degree of autoregulation in the patients. This may be related to the drop in MAPbrain. The different response of MFV-β compared with that of MAPbrain-β also indicates that MFV-β is related to the regulation of cerebral vascular resistance and not systemic blood pressure.
Cell death as a trigger for morphogenesis

The complex morphologies observed in many biofilms play a critical role in the survival of these microbial communities. Recently, the formation of wrinkles has been the focus of many studies aimed at finding fundamental information on morphogenesis during development. While the underlying genetic mechanisms of wrinkling are not well-understood, recent discoveries have led to the counterintuitive idea that wrinkle formation is triggered by localized cell death. This work examines the hypothesis that the material properties of a biofilm both power and control wrinkle formation within biofilms in response to localized cell death. Using an agent-based model and a high-performance platform (Biocellion), we built a model that qualitatively reproduced wrinkle formation in biofilms due to cell death. Through the use of computational simulations, we determined important relationships between cellular level mechanical interactions and changes in colony morphology. These simulations were also used to identify significant cellular interactions that are required for wrinkle formation. These results are a first step towards more comprehensive models that, in combination with experimental observations, will improve our understanding of the morphological development of bacterial biofilms.
FORMULATION AND EVALUATION OF TOPICAL GEL OF MELOXICAM

This study to aim the increasing the drug permeation rate used the permeation enhancers and polymers. The topical gel formulation two polymers has been used carbopol-940 and HPMC in different concentration. The formulation has been analyzed by performed a parameters pH determination, Homogeneity, Extrudability, Skin irritation study, Grittiness, viscosity. In- vitro drug release study shows that the maximum drug permeation through the cellophane membrane produced by HPMC formulation as compared to Carbopol-940.
FLOCCULATION DYNAMICS OF SYNTHETIC AND ACTIVATED SLUDGE IN WASTEWATER TREATMENT

This study has investigated in a comparative fashion the effect of cation, polysaccharide, and Polyelectrolyte on the flocculation dynamics and final properties of both synthetic and activated sludge. The results from experiments indicate that cation, polysaccharide, and Polyelectrolyte could influence sludge floc characteristics as they relate to sludge conditioning. The relationship between polysaccharide and cation concentration was examined at laboratory scale during flocculation with both synthetic and activated sludge; an increase in feed cation concentration led to a decrease in final polysaccharide concentration of the supernatant. The effects of a polyelectrolyte conditioner on sludge conditioning were determined. The results indicated that the cationic Polyelectrolyte had the critical effect on sludge dewatering, and made the improvement of the final properties of sludge. A qualitative link exists between polyelectrolyte conditioner dosage and sludge conditioning for both types of sludge. The two types of sludge also have very similar sludge conditioning. Thus synthetic and activated sludge behave very similarly in terms of their characteristics and sludge conditioning, and synthetic sludge can be used as a surrogate in activated sludge studies. Keywords: Activated sludge; Synthetic sludge; Calcium ions; Polysaccharide; Polyelectrolyte; Sludge properties.
Transaction management in an object-oriented database system

In this paper, we describe transaction management in ORION, an object-oriented database system. The application environments for which ORION is intended led us to implement the notions of sessions of transactions, and hypothetical transactions (transactions which always abort). The object-oriented data model which ORION implements complicates locking requirements. ORION supports a concurrency control mechanism based on extensions to the current theory of locking, and a transaction recovery mechanism based on conventional logging.
Attrition from Web-Based Cognitive Testing: A Repeated Measures Comparison of Gamification Techniques

Background The prospect of assessing cognition longitudinally and remotely is attractive to researchers, health practitioners, and pharmaceutical companies alike. However, such repeated testing regimes place a considerable burden on participants, and with cognitive tasks typically being regarded as effortful and unengaging, these studies may experience high levels of participant attrition. One potential solution is to gamify these tasks to make them more engaging: increasing participant willingness to take part and reducing attrition. However, such an approach must balance task validity with the introduction of entertaining gamelike elements. Objective This study aims to investigate the effects of gamelike features on participant attrition using a between-subjects, longitudinal Web-based testing study. Methods We used three variants of a common cognitive task, the Stop Signal Task (SST), with a single gamelike feature in each: one variant where points were rewarded for performing optimally; another where the task was given a graphical theme; and a third variant, which was a standard SST and served as a control condition. Participants completed four compulsory test sessions over 4 consecutive days before entering a 6-day voluntary testing period where they faced a daily decision to either drop out or continue taking part. Participants were paid for each session they completed. Results A total of 482 participants signed up to take part in the study, with 265 completing the requisite four consecutive test sessions. No evidence of an effect of gamification on attrition was observed. A log-rank test showed no evidence of a difference in dropout rates between task variants (χ22=3.0, P=.22), and a one-way analysis of variance of the mean number of sessions completed per participant in each variant also showed no evidence of a difference (F2,262=1.534, P=.21, partial η2=0.012). Conclusions Our findings raise doubts about the ability of gamification to reduce attrition from longitudinal cognitive testing studies.
Human kidney and liver gluconeogenesis: evidence for organ substrate selectivity.

To assess the contribution of the human kidney to gluconeogenesis (GN) and its role in conversion of glutamine and alanine to glucose, we used a combination of isotopic and organ balance techniques in nine normal postabsorptive volunteers and measured both overall and renal incorporation of these precursors into glucose before and after infusion of epinephrine. In the postabsorptive basal state, renal incorporation of glutamine (27 ± 2 μmol/min) and alanine (2.1 ± 0.5 μmol/min) into glucose accounted for 72.8 ± 3.3 and 3.9 ± 0.5% of their overall incorporation into glucose (37 ± 2 and 51 ± 6 μmol/min, respectively) and 19.0 ± 3.5 and 1.4 ± 0.2%, respectively, of overall renal glucose release. Infusion of epinephrine, which increased systemic and renal glucose release more than twofold ( P< 0.001), increased overall glutamine and alanine incorporation into glucose (both P < 0.001) and increased renal GN from glutamine ( P< 0.001) but not from alanine ( P = 0.15). Renal glutamine GN now accounted for 90.3 ± 4.0% of overall glutamine GN ( P = 0.01 vs. basal), whereas renal alanine GN still accounted for only 4.8 ± 1.7% of overall alanine GN ( P = 0.36 vs. basal). With the assumption that kidney and liver are the only gluconeogenic organs in humans, these results indicate that glutamine GN occurs primarily in kidney, whereas alanine GN occurs almost exclusively in liver. Isotopic studies of glutamine and alanine incorporation into plasma glucose may provide a selective, noninvasive method to assess hepatic and renal GN.
A lifting wavelet based lossless and lossy ECG compression processor for wireless sensors

This work presents an electrocardiogram (ECG) compression processor for wireless sensors with configurable data lossless and lossy compression. Lifting wavelet transforms of 9/7-M and 5/3 are employed for signal decomposition instead of traditional wavelet. A hybrid encoding scheme improves compression efficiency by encoding the higher scales of decomposed coefficients with modified embedded zero-tree wavelet (EZW) and the lowest scale with Huffman encoding. Besides, a transposable register matrix for coefficients buffering during EZW encoding lowers the processing frequency without extra register resource. Implemented in SMIC 40nm CMOS process, the processor only takes a total gate count of 10.8K with 92nW power consumption under 0.5V voltage and achieves a compression ratio of 2.71 for lossless compression and 14.9 for lossy compression with PRD of 0.39%.
Evolution in functional complexity of heart rate dynamics: a measure of cardiac allograft adaptability.

The capacity of self-organized systems to adapt is embodied in the functional organization of intrinsic control mechanisms. Evolution in functional complexity of heart rate variability (HRV) was used as measure of the capacity of the transplanted heart to express newly emergent regulatory order. In a cross-sectional study of 100 patients after (0-10 yr) heart transplantation (HTX), heart rate dynamics were assessed using pointwise correlation dimension (PD2) analysis. A new observation is that, commencing with the acute event of allograft transplantation, the dynamics of rhythm formation proceed through complex phase transitions. At implantation, the donor heart manifested metronome-like chronotropic behavior (PD2 ∼1.0). At 11-100 days, dimensional complexity of HRV reached a peak (PD2 ∼2.0) associated with resurgence in the high-frequency component (0.15-0.5 Hz) of the power spectral density. Subsequent dimensional loss to PD2 ∼1.0 at 20-30 mo after HTX was followed by a progressive near-linear gain in system complexity, reaching PD2 ∼3.0 7-10 yr after HTX. The "dynamic reorganization" in the allograft rhythm-generating system, seen in the first 100 days, is a manifestation of the adaptive capacity of intrinsic control mechanisms. The loss of HRV 2 yr after HTX implies a withdrawal of intrinsic autonomic control and/or development of an entrained dynamic pattern characteristic of extrinsic sympathetic input. The subsequent long-term progressive rise in dimensional complexity of HRV can be attributed to the restoration of a functional order patterning parasympathetic control. The recognition that the decentralized heart can restitute the multidimensional state space of HR generator dynamics independent of external autonomic signaling may provide a new perspective on principles that constitute homeodynamic regulation.
Auricular acupuncture for spinal cord injury related neuropathic pain: a pilot controlled clinical trial

Objective: To obtain preliminary data on the effects of an auricular acupuncture protocol, Battlefield Acupuncture (BFA), on self-reported pain intensity in persons with chronic Spinal Cord Injury (SCI) and neuropathic pain. Design: Pilot randomized delayed entry single center crossover clinical trial at an outpatient rehabilitation and integrative medicine hospital center. Methods: Chronic (> one year post injury) ASIA impairment scale A through D individuals with SCI with injury level from C3 through T12 and below level neuropathic pain with at least five on the Numeric Rating Scale (NRS) were recruited. Twenty-four subjects were randomized to either an eight-week once weekly ten-needle BFA protocol (n = 13) or to a waiting list followed by the BFA protocol (n = 11). Outcome measures: The primary outcome measure was change in the pain severity NRS. Secondary outcome was the Global Impression of Change. Results: Demographically there were no significant differences between groups. Mean pain scores at baseline were higher in acupuncture than control subjects (7.75 ± 1.54 vs. 6.25 ± 1.04, P = 0.027). Although both groups reported significant reduction in pain during the trial period, the BFA group reported more pain reduction than the delayed entry group (average change in NRS at eight weeks –2.92 ± 2.11 vs. −1.13 ± 2.14, P = 0.065). There was a significant difference in groups when a group-by-time interaction in a mixed-effect repeated measures model (P = 0.014). Conclusion: This pilot study has provided proof of concept that BFA has clinically meaningful effect on the modulation of SCI neuropathic pain.
Unsupervised Learning of State Representations for Multiple Tasks

We present an approach for learning state representations in multi-task reinforcement learning. Our method learns multiple low-dimensional state representations from raw observations in an unsupervised fashion, without any knowledge of which task is executed, nor of the number of tasks involved. The method is based on a gated neural network architecture, trained with an extension of the learning with robotic priors objective. In simulated experiments, we show that our method is able to learn better state representations for reinforcement learning, and we analyze why and when it manages to do so.
What is the best measure for assessing diabetes distress? A comparison of the Problem Areas in Diabetes and Diabetes Distress Scale: results from Diabetes MILES–Australia

This study used Rasch analysis to examine the psychometric validity of the Diabetes Distress Scale and the Problem Areas in Diabetes scale to assess diabetes distress in 3338 adults with diabetes (1609 completed the Problem Areas in Diabetes scale (n = 675 type 1 diabetes; n = 934 type 2 diabetes) and 1705 completed the Diabetes Distress Scale (n = 693 type 1 diabetes; n = 1012 type 2 diabetes)). While criterion and convergent validity were good, Rasch analysis revealed suboptimal precision and targeting, and item misfit. Unresolvable multidimensionality within the Diabetes Distress Scale suggests a total score should be avoided, while suboptimal precision suggests that the Physician-related and Interpersonal distress subscales should be used cautiously.
Remarkably Enhanced Room-Temperature Hydrogen Sensing of SnO2 Nanoflowers via Vacuum Annealing Treatment

In this work, SnO2 nanoflowers synthesized by a hydrothermal method were employed as hydrogen sensing materials. The as-synthesized SnO2 nanoflowers consisted of cuboid-like SnO2 nanorods with tetragonal structures. A great increase in the relative content of surface-adsorbed oxygen was observed after the vacuum annealing treatment, and this increase could have been due to the increase in surface oxygen vacancies serving as preferential adsorption sites for oxygen species. Annealing treatment resulted in an 8% increase in the specific surface area of the samples. Moreover, the conductivity of the sensors decreased after the annealing treatment, which should be attributed to the increase in electron scattering around the defects and the compensated donor behavior of the oxygen vacancies due to the surface oxygen adsorption. The hydrogen sensors of the annealed samples, compared to those of the unannealed samples, exhibited a much higher sensitivity and faster response rate. The sensor response factor and response rate increased from 27.1% to 80.2% and 0.34%/s to 1.15%/s, respectively. This remarkable enhancement in sensing performance induced by the annealing treatment could be attributed to the larger specific surface areas and higher amount of surface-adsorbed oxygen, which provides a greater reaction space for hydrogen. Moreover, the sensors with annealed SnO2 nanoflowers also exhibited high selectivity towards hydrogen against CH4, CO, and ethanol.