Miracle-dz/UniFAR-FTUs huggingface dataset:
Be Conscientious, Express your Sentiment!

This paper addresses the issue of how personality recognition can be helpful for sentiment analysis. We exploited the corpus for sentiment analysis released for the SEMEVAL 2013, we automatically annotated personality labels by means of an unsupervised system for personality recognition. We validated the automatic annotation on a small set of Twitter users, whose personality types have been collected by means of an online test. Results show that hashtag position and conscientiousness are the best predictors of sentiment in Twitter.
PTGL - a web-based database application for protein topologies

Protein Topology Graph Library (PTGL) is a database application for the representation and retrieval of protein topologies. Protein topologies are based on a graph-theoretical protein model at secondary structure level. Different views on protein topology are given by four linear notations for their characterization. Protein topologies can be derived at different description levels considering alpha- and beta-structures. The on-line search tool is based on an object-relational database and provides a query browser for data interrogation by string patterns, keyword queries and sequence similarity. Protein topologies are represented both as schematic diagrams and as three-dimensional images.
An association study of a polymorphism in the heparan sulfate proteoglycan gene (perlecan, HSPG2) and Alzheimer's disease

Accumulating evidence indicates that the heparan‐sulfate‐proteoglycan (perlecan, HSPG2), as well as other specific proteoglycans, are involved in amyloidogenesis and tau aggregation in Alzheimer's disease (AD). Moreover, the HSPG2 is located on chromosome 1p36, a region of linkage to late‐onset AD (LOAD). These two criteria, pathological and positional, make the HSPG2 an interesting candidate for an association with AD. We performed a case‐control association study between the common intron 6 BamHI polymorphism at a region of putative heparan‐sulfate (HS) attachment sites in the HSPG2 gene and sporadic AD in Jews. No association was detected with AD, neither as a risk factor nor as a modifier gene affecting the age at disease onset and disease progression. In addition, no interactive effect was found with the known risk factor for AD, the apolipoprotein E (APOE) ε4. These findings show no evidence for association between HSPG2 intron 6 BamHI polymorphism and AD in our population. © 2004 Wiley‐Liss, Inc.
Uncovering information from social media hyperlinks: An investigation of twitter

Analyzing hyperlink patterns has been a major research topic since the early days of the web. Numerous studies reported uncovering rich information and methodological advances. However, very few studies thus far examined hyperlinks in the rapidly developing sphere of social media. This paper reports a study that helps fill this gap. The study analyzed links originating from tweets to the websites of 3 types of organizations (government, education, and business). Data were collected over an 8‐month period to observe the fluctuation and reliability of the individual data set. Hyperlink data from the general web (not social media sites) were also collected and compared with social media data. The study found that the 2 types of hyperlink data correlated significantly and that analyzing the 2 together can help organizations see their relative strength or weakness in the two platforms. The study also found that both types of inlink data correlated with offline measures of organizations' performance. Twitter data from a relatively short period were fairly reliable in estimating performance measures. The timelier nature of social media data as well as the date/time stamps on tweets make this type of data potentially more valuable than that from the general web.
Feedforward and feedback optimal vibration rejection for active suspension discrete-time systems under in-vehicle networks

This paper studies the vibration rejection problem of active suspension discrete-time systems under in-vehicle networks and designs a controller of feedforward and feedback optimal vibration rejection. Based on the ground displacement power spectral density, an discrete-time exosystem is employed to estimate the random road disturbances. A two degree of freedom discrete-time system is introduced to describe the active suspension under in-vehicle networks. Then, the original vibration control is formulated as the optimal control for a linear discrete-time system affected by external disturbances. The feedforward and feedback optimal vibration rejection law (FFOVRL) is designed by solving the Riccate and Stein equations, in which the feedforward term incorporates the information of the random road disturbances and the feedback loop includes the status of suspension system. The feasibility and effectiveness of the proposed approaches are validated by an active suspension structure.
REVISIÓN DE LAS MEDIDAS DEL TRASTORNO OBSESIVO-COMPULSIVO (TOC)

The objective of the study was the systematic review of the literature on Obsessive and Compulsive Disorder (OCD) measures. Some 68 articles were selected after an exhaustive search in SCOPUS and PsycINFO. These papers were those that, as well as including OCD measures, were considered as relevant according to criteria previously established from the analysis of 1066 abstracts. Coding was carried out by means of exhaustive and mutually exclusive ad hoc category systems. Some psychometric properties as well as the neuropsychological evidence employed in the validation of the most frequently used measures were described. Results indicate that the social and emotional facets are hardly taken into account; some other limitations of OCD measures are highlighted. The use of advanced psychometric models and the consideration of affective as well as cognitive neuropsychological evidence are suggested in order to improve current OCD measurement instruments.
Inhibition of Cytochrome P450&ohgr;-Hydroxylase: A Novel Endogenous Cardioprotective Pathway

Cytochrome P450s (CYP) and their arachidonic acid (AA) metabolites have important roles in regulating vascular tone, but their function and specific pathways involved in modulating myocardial ischemia–reperfusion injury have not been clearly established. Thus, we characterized the effects of several selective CYP&ohgr;-hydroxylase inhibitors and a CYP&ohgr;-hydroxylase metabolite of AA, 20-hydroxyeicosatetraenoic acid (20-HETE), on the extent of ischemia–reperfusion injury in canine hearts. During 60 minutes of ischemia and particularly after 3 hours of reperfusion, 20-HETE was produced at high concentrations. A nonspecific CYP inhibitor, miconazole, and 2 specific CYP&ohgr;-hydroxylase inhibitors, 17-octadecanoic acid (17-ODYA) and N-methylsulfonyl-12,12-dibromododec-11-enamide (DDMS), markedly inhibited 20-HETE production during ischemia–reperfusion and produced a profound reduction in myocardial infarct size (expressed as a percent of the area at risk) (19.6±1.7% [control], 8.4±2.5% [0.96 mg/kg miconazole], 5.9±2.2% [0.28 mg/kg 17-ODYA], and 10.8±1.8% [0.40 mg/kg DDMS], P<0.05, respectively). Conversely, exogenous 20-HETE administration significantly increased infarct size (26.9±1.9%, P<0.05). Several CYP&ohgr;-hydroxylase isoforms, which are known to produce 20-HETE such as CYP4A1, CYP4A2, and CYP4F, were demonstrated to be present in canine heart tissue and their activity was markedly inhibited by incubation with 17-ODYA. These results indicate an important endogenous role for CYP&ohgr;-hydroxylases and in particular their product, 20-HETE, in exacerbating myocardial injury in canine myocardium. The full text of this article is available online at http://circres.ahajournals. org.
Egr-1 mRNA expression is a marker for the direction of mammalian ocular growth.

PURPOSE The immediate early gene Egr-1 is thought to form part of the pathway that mediates abnormal ocular growth. This study investigated whether the mRNA expression levels of Egr-1 in a mammalian retina are modulated differentially, depending on the direction of ocular growth. METHODS To induce accelerated growth and myopia, guinea pigs wore a -5 diopter (D) lens over one eye from 4 to 11 days of age. To induce inhibited growth, the lens was removed after 7 days of -5 D lens wear, and the eye allowed to recover from myopia for 3 days. Ocular parameters and Egr-1 mRNA levels were subsequently assessed, and compared to untreated fellow eyes and eyes from untreated littermates. Possible circadian changes in Egr-1 mRNA levels were also determined in 18 additional animals by taking measures every 4 hours during a 24-hour cycle. RESULTS Ocular compensation to a -5 D lens occurred after 7 days (Δ -4.8 D, Δ +147 μm growth, N = 20). In 5 highly myopic eyes (Δ -7.4 D), Egr-1 mRNA levels in the retina were significantly downregulated relative to contralateral control (51%) and age-matched untreated (47%) eyes. Three days after the -5 D lens was removed, eyes had recovered from the myopia (Δ -0.5 D, relative change of +2.9 D, N = 4) and Egr-1 mRNA levels were significantly elevated relative to contralateral (212%) and untreated (234%) eyes, respectively. Normal Egr-1 mRNA expression was higher in the middle of the day than in the middle of the night. Immunolabeling showed strong Egr-1 reactivity in cell bodies in the inner nuclear and ganglion cell layers. CONCLUSIONS Egr-1 mRNA levels in a mammalian retina show a bi-directional persistent response to opposing ocular growth stimuli. This suggests retinal Egr-1 might act as a signal for the direction of ocular growth in different species.
Den anfrätta stammen : Nils von Hofsten, eugeniken och steriliseringarna 1909-1963

Zoologen Nils von Hofsten (1881-1967) var en av de mest inflytelserika personerna i Sverige pa omradena eugenik och steriliseringar. I denna avhandling belyses detta inflytande, som strackte sig ov .
Multipoint analysis of quantitative traits

Complete multipoint analysis as implemented by MAPMAKER/SIBS was used to identify the chromosomal regions with the strongest evidence of linkage. Three different quantitative sib‐pair methods were compared. For each trait the maximum lod/Z score was used to implicate a chromosomal region. For trait Q5, chromosome 5, the analysis was repeated in a second data set to test for replication of the result from the first data set. The initial screen was carried out using complete parental information and the first sibling pair from each nuclear family. The effect of removing the parental genotypes and the use of multiple independent sibs was examined in the second data set for Q5, chromosome 5. © 1997 Wiley‐Liss, Inc.
Forty years of genetics with Streptomyces: from in vivo through in vitro to in silico.

As an undergraduate at Cambridge in the early 1950s, I had found genetics the most exciting part of my courses. This was the main motivation for choosing Botany as my Part II (final year) option in the academic year 1953}54. Granted, there was the Department of Genetics at Cambridge, headed by none other than Ronald Fisher, the father of biological statistics and a true genius, but an advanced qualification in mathematics was a de facto entry ticket to Part II Genetics, reflecting the strong mathematical basis of research in that Department. In the Botany School, ‘biochemical genetics ’ was being studied – using Neurospora crassa – by Harold Whitehouse and Lewis Frost. During the Part II course in Botany, they far-sightedly emphasized the power and promise of microbial genetics for the future understanding of gene structure and function. In choosing a PhD project to start in October 1954 I heeded their advice. One of the topics on offer was Streptomyces. Here was a group of microbes apparently ‘ intermediate between bacteria and fungi ’, and so they could not fail to be interesting from a genetic point of view, given the clear differences that were emerging between the genetics of the few bacteria so far studied and the genetics of fungi and higher organisms. In the Pneumococcus, Escherichia coli and Salmonella typhimurium, incomplete genomes were transferred from donor to recipient strains, by any of three bizarre processes (transformation, conjugation and transduction), to yield incomplete zygotes, whereas in fungi and higher organisms (except those that were asexual) life cycles, including a complete diploid stage and meiosis, were the rule.
A FEM for an Optimal Control Problem of Fractional Powers of Elliptic Operators

We study solution techniques for a linear-quadratic optimal control problem involving fractional powers of elliptic operators. These fractional operators can be realized as the Dirichlet-to-Neumann map for a nonuniformly elliptic problem posed on a semi-infinite cylinder in one more spatial dimension. Thus, we consider an equivalent formulation with a nonuniformly elliptic operator as state equation. The rapid decay of the solution to this problem suggests a truncation that is suitable for numerical approximation. We discretize the proposed truncated state equation using first degree tensor product finite elements on anisotropic meshes. For the control problem we analyze two approaches: one that is semi-discrete based on the so-called variational approach, where the control is not discretized, and the other one is fully discrete via the discretization of the control by piecewise constant functions. For both approaches, we derive a priori error estimates with respect to the degrees of freedom. Numerical experiments validate the derived error estimates and reveal a competitive performance of anisotropic over quasi-uniform refinement.
Diagnosis of DIC in Very Low Birth Weight Infants

Disseminated intravascular coagulation (DIC) occurs most frequently during the neonatal period. We have already established criteria for the early diagnosis of DIC in newborn infants, based on the analysis of clinical and laboratory findings in neonates with and without DIC. In that study, laboratory findings for subjects without DIC were evaluated based on the results obtained from neonates whose birth weights were more than 1500 g. Accordingly, these criteria are not necessarily applicable to the diagnosis of DIC in very low birth weight infants (VLBWI) since the physiological and pathological states of coagulation and fibrinolysis in VLBWI may differ from those of term newborn infants. Therefore, we measured platelet counts, plasma fibrinogen contents and the fibrin degradation product (D-dimer) concentrations in VLBWI with and without DIC. These findings indicate that the scoring system for platelet counts in our diagnostic criteria of DIC in newborn infants is applicable to the diagnosis of DIC in VLBWI. However, our scoring systems for fibrinogen and D-dimer were not usable for the diagnostic criteria of DIC in VLBWI since fibrinogen and D-dimer concentrations in VLBWI without DIC were lower than those in non-DIC neonates whose birth weights were above 1500 g. We devised criteria for the diagnosis of DIC in VLBWI based on those findings.
Entrepreneurship, victimization and the historical legacy of war: evidence from Eastern Europe and Central Asia

We study the eect of family victimization and displacement during World War II on entrepreneurship and employment in the former communist countries of Eastern Europe and Central Asia. Using the 2010 Life in Transition Survey, we document a limited impact of war exposure on overall employment rates, employment with a formal contract, or whether the respondent works in a high-skill industry. However, our analysis points to long-term scarring eects of war on entrepreneurial behavior, possibly working through dierent attitudes toward institutions and redistribution in individuals from victimized families. Our results are robust to controlling for xed sub-national factors, a wide range of individual characteristics, as well as to using non-survey measures of war exposure.
Functional Principal Component Analysis of Vocal Tract Area Functions

This paper shows the application of a functional version of principal component analysis to build a parametrization of vocal tract area functions for vowel production. Sets of measured area values for ten vowels are expressed as smooth functional data and next decomposed into a mean area function and a basis of orthogonal eigenfunctions. Interpretations of the first four eigenfunctions are provided in terms of tongue movements and vocal tract length variations. Also, an alternative set of eigenfunctions with closer association to specific regions of the vocal tract is obtained via a varimax rotation. The general intention of the paper is to show the benefits of a functional approach to analyze vocal tract shapes and motivate further applications.
Asset Pricing with Endogenous Disasters

We develop a parsimonious model in which frictions in the labor market may turn small, continuous labor productivity declines into large drops in employment, endogenously causing disasters. Assuming one state variable and CRRA agents, we solve for prices in closed form, calibrate the model using labor market data, and show that this simple setting captures the high, countercyclical volatility and equity premium observed in the United States. Moreover, returns in our model are conditionally predicted by dividend yields. Finally, as in the data, in our setting the disasters are larger when the capital's share of income is higher. The Author 2013. Published by Oxford University Press on behalf of The Society for Financial Studies. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. , Oxford University Press.
Recommendation Based Trust Model with an Effective Defence Scheme for MANETs

The reliability of delivering packets through multi-hop intermediate nodes is a significant issue in the mobile ad hoc networks (MANETs). The distributed mobile nodes establish connections to form the MANET, which may include selfish and misbehaving nodes. Recommendation based trust management has been proposed in the literature as a mechanism to filter out the misbehaving nodes while searching for a packet delivery route. However, building a trust model that adopts recommendations by other nodes in the network is a challenging problem due to the risk of dishonest recommendations like bad-mouthing, ballot-stuffing, and collusion. This paper investigates the problems related to attacks posed by misbehaving nodes while propagating recommendations in the existing trust models. We propose a recommendation based trust model with a defence scheme, which utilises clustering technique to dynamically filter out attacks related to dishonest recommendations between certain time based on number of interactions, compatibility of information and closeness between the nodes. The model is empirically tested under several mobile and disconnected topologies in which nodes experience changes in their neighbourhood leading to frequent route changes. The empirical analysis demonstrates robustness and accuracy of the trust model in a dynamic MANET environment.
A Novel Numerical Approach for a Nonlinear Fractional Dynamical Model of Interpersonal and Romantic Relationships

In this paper, we propose a new numerical algorithm, namely q-homotopy analysis Sumudu transform method (q-HASTM), to obtain the approximate solution for the nonlinear fractional dynamical model of interpersonal and romantic relationships. The suggested algorithm examines the dynamics of love affairs between couples. The q-HASTM is a creative combination of Sumudu transform technique, q-homotopy analysis method and homotopy polynomials that makes the calculation very easy. To compare the results obtained by using q-HASTM, we solve the same nonlinear problem by Adomian’s decomposition method (ADM). The convergence of the q-HASTM series solution for the model is adapted and controlled by auxiliary parameter ℏ and asymptotic parameter n. The numerical results are demonstrated graphically and in tabular form. The result obtained by employing the proposed scheme reveals that the approach is very accurate, effective, flexible, simple to apply and computationally very nice.
The changing patient.

It is interesting to see how the person behind the ‘patient’ has changed with the development of the modern health service. Many textbooks paid little attention to the individuality and sensitivity of the patient who was the focus of many nursing procedures and functions. Even the Handbook for Ward Sisters(Scales, 1952), which devoted 16 pages to the subject, refers to ‘The Patient’ like an object that is passed around and cared for by nurses who should know what to do at various stages or steps in the busy routine of hospital life
Some Heretical Thoughts on What Our Students Are Telling Us.

What we settle down to read are the "free-style comments," where the students are encouraged to write (anonymously, of course) what they think of the book, the exams, and, of course, of the lecturer. Many, not all, universities give students the opportunity to express themselves in this way. Some of us have learned to avoid asking silly questions with predictable responses, such as "What is the best part of the course? "
Clustering Motion

Abstract Given a set of moving points in ℝd, we show how to cluster them in advance, using a small number of clusters, so that at any time this static clustering is competitive with the optimal k-center clustering at that time. The advantage of this approach is that it avoids updating the clustering as time passes. We also show how to maintain this static clustering efficiently under insertions and deletions. To implement this static clustering efficiently, we describe a simple technique for speeding up clustering algorithms and apply it to achieve faster clustering algorithms for several problems. In particular, we present a linear time algorithm for computing a 2-approximation to the k-center clustering of a set of n points in ℝd. This slightly improves the algorithm of Feder and Greene, that runs in Θ(n log k) time (which is optimal in the algebraic decision tree model).
The Cost of Negative Returns

We study the impact of negative returns on the health of a given nancial portfolio. It is often the case that a series of signicant negative returns trigger a credit event such as a downgrade in rating, or even a default of the portfolio owner. We focus our attention on a Weighted Average of Ordered Returns, which is a statistic that allows us to weight returns according to their relative adverse impact. We use an option pricing approach to derive the theoretical price and properties of a forward, a swap contract, a call and a put option written on the Weighted Average of Ordered Returns under dierent assumptions about the distribution of returns. The models of returns considered in this paper are dened by the following underlying price processes: geometric Brownian motion, Merton model with Poisson jumps, and GARCH model. We present a convergence result which states that the price of a forward on the Weighted Average of Ordered Returns converges to the theoretical law invariant coherent risk measure. Finally, we show that the forward price process itself satises the axioms of a dynamic coherent risk measures.