Miracle-dz/UniFAR-FTUs huggingface dataset:
Pilot study of flesinoxan, a 5‐HT1A agonist, in major depression: Effects on sleep REM latency and body temperature

Flesinoxan is a highly potent and selective 5‐HT1A full agonist, active in several models of depression. In this pilot open study, flesinoxan (4 mg/d) was administered orally for 4 weeks in 16 major depressive, mostly treatment‐resistant inpatients exhibiting a score of at least 19 on the Hamilton depression sale. Weekly ratings included Hamilton depression scale, Montgomery and Asberg depression scale (MADRS), and Clinical Global Impressions (CGI). Results showed considerable improvement in depressive symptomatology with mean MADRS scores (SD) dropping from 35.7 (10–40) to 13.0 (11.9) and CGI‐illness severity from 5.69 (1.14) to 2.73 (1.62) after 4 weeks of treatment. Moreover, 13 patients were classified as much or very much improved on the CGI‐global improvement. The tolerance of flesinoxan was excellent, with only four patients exhibiting side‐effects. In contrast to acute studies with 5HT1A agonists, flesinoxan induced no significant decrease in daily oral temperature over the 4‐week period. In eight melancholic patients, the mean REM latency (SD) of respectively 35.6 (15.9) and 40.2 (17.9) min during two baseline nights significantly increased to 51.9 (20.9) min during a double‐blind challenge night with flesinoxan 1 mg as compared to 42.0 (16.1) min with placebo, and to respectively 55.6 (29.9) and 55.6 (30.2) min during the last two treatment nights. All these findings encourage further developments of flesinoxan as a promising antidepressant.
Joint symbol detection and timing estimation using particle filtering

The paper addresses joint estimation of the timing epoch and detection of the transmitted symbols in a digital communication system. Most timing recovery techniques found in the literature are either approximately or heuristically derived, since optimal estimators are analytically intractable. Our approach to the problem relies on modeling the symbol timing as an autoregressive process. In this way, the digital communication system can be mathematically represented by a dynamic system in state-space form and the sequential Monte Carlo (SMC) methodology can be applied. SMC algorithms are powerful tools for Bayesian estimation that are based on representing the posterior distribution of the system state by a discrete measure with random support. This representation can be updated recursively, as new information becomes available, allowing for optimal estimation of both the transmitted symbols and their timing.
A fine-grained reconfigurable logic array based on double gate transistors

A fine-grained reconfigurable architecture based on double gate technology is presented. The logic function operating on the first gate of a double gate (DG) transistor is reconfigured by altering the bias on its second gate. A compact reconfigurable cell is proposed that merges two stacked 3-state resonant tunneling devices and non-silicon transistors and "hides" the cost of reconfiguration by exploiting vertical integration. Each cell in the array can act as logic or interconnect, or both - contrasting with current FPGA structures in which logic and interconnect are built and configured largely as separate items. Simulation results for a SOI DG-MOSFET implementation is presented and two alternative non-silicon device technologies, metal-insulator-metal and carbon nanotube transistors, are briefly explored Of these, carbon nanotube devices appear to offer the highest current drive at the limit of scaling and will operate into the gigahertz range but then only within architectures that are locally connected.
CBR in the Health Sciences

The problem of retrieving time series similar to a specified query pattern has been recently addressed within the Case Based Reasoning (CBR) literature. Providing a flexible and efficient way of dealing with such an issue is of paramount importance in medical domains, where many patient parameters are often collected in the form of time series. In the past, we have developed a framework for retrieving cases with time series features, relying on Temporal Abstractions. With respect to more classical (mathematical) approaches, our framework provides significant advantages. In particular, multi-level abstraction mechanisms and proper indexing techniques allow for flexible query issuing, and for efficient and interactive query answering. In this paper, we present an extension to such a framework, aimed at supporting sub-series matching as well. Indeed, sub-series retrieval may be crucial in medical applications, when the whole time series evolution is sometimes not of interest, while critical patterns to be search for are only “local”. Moreover, their relative order, but not their precise location in time, may be known, and an interactive search, at different abstraction levels, may be of great help for the medical decision maker. The framework is currently being applied to the hemodialysis domain.
Potential Human Pathogenic Bacteria in a Mixed Urban Watershed as Revealed by Pyrosequencing

Current microbial source tracking (MST) methods for water depend on testing for fecal indicator bacterial counts or specific marker gene sequences to identify fecal contamination where potential human pathogenic bacteria could be present. In this study, we applied 454 high-throughput pyrosequencing to identify bacterial pathogen DNA sequences, including those not traditionally monitored by MST and correlated their abundances to specific sources of contamination such as urban runoff and agricultural runoff from concentrated animal feeding operations (CAFOs), recreation park area, waste-water treatment plants, and natural sites with little or no human activities. Samples for pyrosequencing were surface water, and sediment collected from 19 sites. A total of 12,959 16S rRNA gene sequences with average length of ≤400 bp were obtained, and were assigned to corresponding taxonomic ranks using ribosomal database project (RDP), Classifier and Greengenes databases. The percent of total potential pathogens were highest in urban runoff water (7.94%), agricultural runoff sediment (6.52%), and Prado Park sediment (6.00%), respectively. Although the numbers of DNA sequence tags from pyrosequencing were very high for the natural site, corresponding percent potential pathogens were very low (3.78–4.08%). Most of the potential pathogenic bacterial sequences identified were from three major phyla, namely, Proteobacteria, Bacteroidetes, and Firmicutes. The use of deep sequencing may provide improved and faster methods for the identification of pathogen sources in most watersheds so that better risk assessment methods may be developed to enhance public health.
Characterization of antennal sensilla, larvae morphology and olfactory genes of Melipona scutellaris stingless bee

There is growing evidence in the literature suggesting that caste differentiation in the stingless bee, Melipona scutellaris, and other bees in the genus Melipona, is triggered by environmental signals, particularly a primer pheromone. With the proper amount of food and a chemical stimulus, 25% of females emerge as queens, in agreement with a long-standing “two loci/two alleles model” proposed in the 1950s. We surmised that these larvae must be equipped with an olfactory system for reception of these chemical signals. Here we describe for the first time the diversity of antennal sensilla in adults and the morphology of larvae of M. scutellaris. Having found evidence for putative olfactory sensilla in larvae, we next asked whether olfactory proteins were expressed in larvae. Since the molecular basis of M. scutellaris is still unknown, we cloned olfactory genes encoding chemosensory proteins (CSP) and odorant-binding proteins (OBPs) using M. scutellaris cDNA template and primers designed on the basis CSPs and OBPs previously reported from the European honeybee, Apis mellifera. We cloned two CSP and two OBP genes and then attempted to express the proteins encoded by these genes. With a recombinant OBP, MscuOBP8, and a combinatorial single-chain variable fragment antibody library, we generated anti-MscuOBP8 monoclonal antibody. By immunohistochemistry we demonstrated that the anti-MscuOBP8 binds specifically to the MscuOBP8. Next, we found evidence that MscuOBP8 is expressed in M. scutellaris larvae and it is located in the mandibular region, thus further supporting the hypothesis of olfactory function in immature stages. Lastly, molecular modeling suggests that MscuOBP8 may function as a carrier of primer pheromones or other ligands.
Marital and coparenting qualities: Associations with parenting cognitions

Parenting self-efficacy is an important construct in understanding parents’ choices about their child-rearing. Associations between marital and coparenting relationships have been established in prior research. Most of these studies used global assessments of marital quality, marital satisfaction, or measures of conflict to predict to the quality of the coparenting relationship. The present study is unique in that it utilizes multiple dimensions of marital quality, including satisfaction, maintenance strategies, and conflict, to examine the associations between marriage, coparenting, and parenting self-efficacy. These associations were explored using the Family Systems framework, comparing the explanatory power of the additive and compensatory processes. Of the marital quality indices, maintenance was the strongest, most consistent predictor of parenting cognitions for mothers and fathers, predicting to both parenting self-efficacy and meta-parenting. Mothers’ reports of marital satisfaction were negatively associated with their, and their partner’s, parenting self-efficacy. Undermining coparenting was predictive of parenting self-efficacy for mothers and fathers, but only predictive of meta-parenting for mothers. There was evidence supporting positive additive effects of marriage and coparenting on parenting self-efficacy. Maintenance for mothers, and marital satisfaction for fathers, combined with supportive coparenting to predict to even greater parenting self-efficacy. There was also support for the compensatory effect of marital quality on parenting selfefficacy for fathers. Fathers reporting higher levels of maintenance in combination with higher levels of undermining coparenting maintained their levels of parenting self-
Single Nucleotide Variants in Transcription Factors Associate More Tightly with Phenotype than with Gene Expression

Mapping the polymorphisms responsible for variation in gene expression, known as Expression Quantitative Trait Loci (eQTL), is a common strategy for investigating the molecular basis of disease. Despite numerous eQTL studies, the relationship between the explanatory power of variants on gene expression versus their power to explain ultimate phenotypes remains to be clarified. We addressed this question using four naturally occurring Quantitative Trait Nucleotides (QTN) in three transcription factors that affect sporulation efficiency in wild strains of the yeast, Saccharomyces cerevisiae. We compared the ability of these QTN to explain the variation in both gene expression and sporulation efficiency. We find that the amount of gene expression variation explained by the sporulation QTN is not predictive of the amount of phenotypic variation explained. The QTN are responsible for 98% of the phenotypic variation in our strains but the median gene expression variation explained is only 49%. The alleles that are responsible for most of the variation in sporulation efficiency do not explain most of the variation in gene expression. The balance between the main effects and gene-gene interactions on gene expression variation is not the same as on sporulation efficiency. Finally, we show that nucleotide variants in the same transcription factor explain the expression variation of different sets of target genes depending on whether the variant alters the level or activity of the transcription factor. Our results suggest that a subset of gene expression changes may be more predictive of ultimate phenotypes than the number of genes affected or the total fraction of variation in gene expression variation explained by causative variants, and that the downstream phenotype is buffered against variation in the gene expression network.
Governance As a Catalyst for Policy Change

Policymakers and leaders have been calling for changes in the Academy for nontenure-track faculty. This study focuses on the role of governance in creating that policy change, and the practices facilitating their role in changing the institution through governance. Findings include: governance facilitating day-to-day changes, establishing nontenure-track credibility, and dismantling stereotypes; and policies that define faculty roles and enable participation.
Immersed in literacy learning: One staff shifts its thinking and lives to tell about it

Abstract Using Cambourne's model of Natural Learning and Literacy Acquisition (1985), this paper examines one staffs professional development as they are immersed in literacy learning. This year‐long qualitative study examined the changes in teachers’ understanding of literacy concepts, as well as factors that contributed to or inhibited these changes. Data were gathered from multiple sources, including lessons plans and focus group interviews. Two conditions from Cambourne's model, immersion and approximation, are discussed. As teachers were immersed in learning, they connected the reading to their teaching in significant ways, they asked specific questions and they developed a common language. As they approximated in their classrooms, they were initially hesitant, then more willing to “have a go. ” Finally, they described changes in their literacy thinking and teaching.
Talent identification and development in youth rugby players: A research review

Several South African studies were conducted during the past twelve years (1995 to 2007) as part of a research project on Talent Identification and Development. The main objective of this project was to compile the profile of a potential talented and elite youth rugby player, primarily within the conceptual research model proposed by Salmela and Regnier (1983). Hundreds of elite youth rugby players, within the age range 10 to 19 years old, were tested on several anthropometric, physical and motor abilities, game specific skills, and injury epidemiology. The research project was extended to England and New Zealand, and the data compared with that of South African teams. Other possible variables of talent identification, including proprioception, balance, plyometric strength, injuries, and ethical behaviour, were also investigated. The aim of this research review is to provide scientific evidence concerning the profile of an elite youth rugby player, thereby providing variables, assessment tools, and recommendations to coaches, selectors, administrators, and scouts, which may be used in the identification, selection, and development of future elite rugby players. Hopefully, this research review will furthermore stimulate future research on talent identification and development within youth team sport.
Body politicking and the phenomenon of ‘passing’

The author takes a transdisciplinary approach to the study of body politics. She careens through topics of feminism, religion, social capital, stigma, heteronormativity, whiteness, colorblind racism in her discussion of access and acceptance granted or denied. This access and acceptance are based upon how the female bodies of two women are perceived differently in the same setting, although neither woman is part of mainstream society. Using a journey with a colleague to juxtapose visible otherness from hidden otherness, the author discusses the phenomenon of ‘‘passing. ’’
The Open University ’ s repository of research publications and other research outputs What characteristics of the gamers ’ profile should be taken into account in player-centred game design ? Conference Item

In this paper, we introduce the theory of trait Emotional Intelligence (‘trait EI’) as a personality theory that could assist in exemplifying the gamers’ profile and contribute to the design of player-center game experiences. Data from two studies (a game-specific and a game-general one) led to a number of playercentered playability principles that could inform the design of adaptable games and games targeting specific gaming audiences. The gamers’ emotional characteristics were found to be of prominent importance to the design of good games.
S tat CC : Design and Evaluation

This work presents StatCC, a simple and efficient model for estimating the shared cache miss ratios of co-scheduled applications on architectures with a hierarchy of private and shared caches. StatCC leverages the StatStack cache model to estimate the co-scheduled applications’ cache miss ratios from their individual memory reuse distance distributions, and a simple performance model that estimates their CPIs based on the shared cache miss ratios. These methods are combined into a system of equations that explicitly models the CPIs in terms of the shared miss ratios and can be solved to determine both. The result is a fast algorithm with a 2% error across the SPEC CPU2006 benchmark suite compared to a simulated in-order processor and a hierarchy of private and shared caches.
A common mechanism for antenna-to-Leg transformation in Drosophila: suppression of homothorax transcription by four HOM-C genes.

The Drosophila HOM-C genes encode transcription factors containing the DNA-binding homeodomain. Mutations in the HOM-C genes can cause specific homeotic transformation, suggesting that the HOM-C genes determine segmental identities by acting on different target genes. However, misexpression of several HOM-C genes in the antenna disc causes similar antenna-to-leg transformations. Here we show that the Scr, Antp, Ubx, and abd-A HOM-C genes all exert their effects through a common mechanism: suppressing the transcription of the homothorax (hth) homeobox gene and thereby preventing the nuclear localization of the Extradenticle homeodomain protein. We also show that ectopic hth expression can cause duplication of the proximodistal axis of the antenna, suggesting that it is involved in proximodistal development of the antenna.
The measurement of personality and behavior disorders by the I. P. A. T. Music Preference Test.

On the wide research front which is roughly designated by "projective tests," but perhaps more accurately by "misperception tests" (1), few recent advances have been so promising as that connected with music perception. The powerful and immediate connection of musical stimulation with emotional experience, and the many indications that unconscious needs gain satisfaction through this medium, have long pointed to measures of musical preference as effective avenues to deeper aspects of personality. Moreover, the lack of verbal content is itself, on general principles, a promise that the verbal, cognitive defenses of the censor may be by-passed and the emotional needs probed more directly without distortion by defense elaborations.
Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX–rich basement membrane zone

Collagen XIX is an extremely rare extracellular matrix component that localizes to basement membrane zones and is transiently expressed by differentiating muscle cells. Characterization of mice harboring null and structural mutations of the collagen XIX (Col19a1) gene has revealed the critical contribution of this matrix protein to muscle physiology and differentiation. The phenotype includes smooth muscle motor dysfunction and hypertensive sphincter resulting from impaired swallowing-induced, nitric oxide–dependent relaxation of the sphincteric muscle. Muscle dysfunction was correlated with a disorganized matrix and a normal complement of enteric neurons and interstitial cells of Cajal. Mice without collagen XIX exhibit an additional defect, namely impaired smooth-to-skeletal muscle cell conversion in the abdominal segment of the esophagus. This developmental abnormality was accounted for by failed activation of myogenic regulatory factors that normally drive esophageal muscle transdifferentiation. Therefore, these findings identify collagen XIX as the first structural determinant of sphincteric muscle function, and as the first extrinsic factor of skeletal myogenesis in the murine esophagus.
Psychology of Religion and Neurobiology: Which Relationship? *

Given that (a) psychologists of religion as a scientific community so far have shown little interest in neurobiology, and (b) neurobiology may become important for our field in the not too distant future, an attempt is made to present and discuss neurobiology and its conceivable interactions with psychology of religion. The long-standing debate about the philosophical grounding of the mind-body problem is recalled, as well as the scope of neurobiology and its research methods. Psychology of religion may assist neurobiology by providing research data that could serve as material for constructing testable neurobiological hypotheses, data resulting, for instance, from studying an individual's perception of God and the numinous, the psychological characteristics of meditation, deep prayer, contemplation, etc. Psychology of religion could benefit from neurobiology, (a) for assessing differing theoretical concepts regarding, for instance, religious experiences, and (b) for constructing dynamic models of religious development. Possible roadblocks on the way to connecting psychology of religion and neurobiology are pointed out and literature for further reading is provided.
A proposed approach to study the toxicology of complex mixtures of petroleum products: the integrated use of QSAR, lumping analysis and PBPK/PD modeling.

Mixture toxicity is a topic that has become a matter of concern during the last two decades. One of the major problems with assessing the toxicity of mixtures and the associated human and environmental risk is the large number of possible mixtures, as well as the fact that the actual mixture effect for a given set of constituents might strongly depend on the actual composition of the mixture, i.e., the ratios of the constituent, as well as their nature. This paper presents a possible approach to describe and thereby better understand the pharmacokinetics and dynamics of complex mixtures by combining quantitative structure-activity relationships to predict needed parameters, lumping to reduce the complexity of the problem, and physiologically based pharmacokinetic/pharmacodynamic modeling to integrate all this information into a complete toxicological description of the mixture. It is our hope that by presenting this conceptual approach we might be able to stimulate some criticisms and discussions in the toxicology community regarding this complex and yet very important area of research.