Miracle-dz/UniFAR-FTUs huggingface dataset:
Collaboration in Public Policy and Practice: Perspectives on Boundary Spanners

and in Chapter 5 develop the idea of the “fellow traveller”. This idea incorporates the social worker acting as a companion for a time on the service user’s spiritual journey. The notion of spiritual care is a theme running throughout the text, confronting the reader with the question of how this care is delivered to the service user in an holistic and culturally respectful way. I think the uniqueness of the book lies in its ability to take the reader beyond the individual consideration of the place of spirituality in social work to how it fits in relation to multidisciplinary teams, communities, and the global setting. The authors have managed to draw together significant pieces of work (e.g., Zapf, 2007) around the interrelatedness of person and environment, and incorporate this material successfully into an overall theme of considering spirituality in the context of social work delivery, from the micro to the macro level. The publication is well laid out with logical sequencing from one chapter to the next, but would have grabbedmy initial attentionmore firmly had the cover beenmore appealing. Given that its narrative was partly related to the diverse expressions of spirituality, it might have been useful to attract the reader’s attention with a cover that had real-life examples. I would recommend this book as an important contributor to the ongoing discussions around spirituality and social work, pushing as it does towards a wider consideration of its applicability for practitioners, students, service users, and academics.
Characterization of PcaQ, a LysR-type transcriptional activator required for catabolism of phenolic compounds, from Agrobacterium tumefaciens

Previous work demonstrated that catabolism of the phenolic compounds p-hydroxybenzoate and protocatechuate via the beta-ketoadipate pathway in Agrobacterium tumefaciens is mediated by a regulatory gene, pcaQ, that acts in trans to elicit expression of many of the enzymes encoded by the pca genes. There was evidence that five pca structural genes are organized in a polycistronic operon transcribed in the order pcaDCHGB. The pcaQ gene is upstream of this operon. The activator encoded by pcaQ was novel in having the metabolite beta-carboxy-cis,cis-muconate as a coinducer. This communication reports the nucleotide sequence of pcaQ and identifies its deduced polypeptide product as a member of the LysR family of regulatory molecules. PcaQ has a calculated molecular weight of 33,546, which is consistent with the size of LysR relatives. Like many other LysR members, PcaQ serves as an activator at the level of transcription, it has a conserved amino-terminal domain, and its gene is transcribed divergently from the operon that it regulates and is subject to negative autoregulation. Studies of coinducer specificity identified an unstable pathway metabolite, gamma-carboxymuconolactone, as a second coinducer. Analysis of expression from a pcaD::lacZ promoter probe plasmid revealed that PcaQ and the coinducer exert their effect on a 133-nucleotide region upstream of pcaD. The nucleotide sequence of this region in a mutant strain constitutive for enzymes encoded by the pcaDCHGB operon identified nucleotides likely to be involved in the pcaDCHGB promoter and substantiated the inclusion of five pca structural genes in the operon.
Learning How to Consume and Returns to Product Promotion

This paper presents the computational model of consumer behaviour. We consider two sources of product specific consumer skill acquisition, termed here as learning how to consume: learning by consuming and consumer socialization. Consumers utilize these two sources in order to derive higher valuations for products they are consuming. In this framework we discuss the behavior of returns to product promotion relative to the changes in product characteristics, such as quality and user-friendliness, as well as in case of varying intensity of consumer socialization. The main finding is that in case of duopoly the dependence of returns to advertising on product quality is not monotonic as it has been claimed by earlier studies. Additional important finding indicating the importance of the models with interacting agents is that returns to advertising exhibit qualitatively different behavior in case of zero intensity of consumer socialization.
Loop bandwidth extension technique for PWM voltage mode DC-DC switching converters

A loop bandwidth extension technique for voltage mode pulsewidth modulated DC-DC switching converters operating in continuous conduction mode is proposed. The conventional fixed ramp is replaced by a ramp with a variable slope adjusted by the output voltage through a low power and area-efficient transconductance cell, pushing the complex pole pair of the LC filter to a higher frequency and hence improves the system loop bandwidth. Theoretical analysis is presented. A prototype buck converter with a maximum load current of 50mA is fabricated using a 0. 35μm CMOS process, occupying an active area of 0.095mm2. Experimental results show that the proposed converter has reduced transient overshoot and undershoot, and settling times are reduced by 50% compared to a conventional voltage mode buck converter. The results match well with the theoretical analysis.
Unsupervised Aspect Term Extraction in Online Drugs Reviews

Aspect mining in drugs reviews has focused on extracting relevant information such as adverse reactions, efficacy of a drug, symptoms and conditions of patients. In our work, a new unsupervised and knowledge-based method is proposed for extracting aspects in drug reviews. The proposed solution is based on linguistic features, more specifically dependency paths in the syntactic tree of a review. The quality of the dependency path rules was investigated in a number of experiments in review corpora associated to three different diseases. Promising results were achieved compared to previous work.
Phage display-based generation of novel internalizing antibody fragments for immunotoxin-based treatment of acute myeloid leukemia

The current standard treatment for acute myeloid leukemia (AML) is chemotherapy based on cytarabine and daunorubicine (7 + 3), but it discriminates poorly between malignant and benign cells. Dose-limiting off‑target effects and intrinsic drug resistance result in the inefficient eradication of leukemic blast cells and their survival beyond remission. This minimal residual disease is the major cause of relapse and is responsible for a 5-year survival rate of only 24%. More specific and efficient approaches are therefore required to eradicate malignant cells while leaving healthy cells unaffected. In this study, we generated scFv antibodies that bind specifically to the surface of AML blast cells and AML bone marrow biopsy specimens. We isolated the antibodies by phage display, using subtractive whole-cell panning with AML M2‑derived Kasumi‑1 cells. By selecting for internalizing scFv antibody fragments, we focused on potentially novel agents for intracellular drug delivery and tumor modulation. Two independent methods showed that 4 binders were internalized by Kasumi-1 cells. Furthermore, we observed the AML‑selective inhibition of cell proliferation and the induction of apoptosis by a recombinant immunotoxin comprising one scFv fused to a truncated form of Pseudomonas exotoxin A (ETA'). This method may therefore be useful for the selection of novel disease-specific internalizing antibody fragments, providing a novel immunotherapeutic strategy for the treatment of AML patients.
Market integration, perceived wealth and household consumption of river turtles (Podocnemis spp.) in eastern lowland Bolivia

Written records indicate that humans in the Bolivian Amazon have utilized Podocnemis river turtles in their diets since at least the 16th century, resulting in their decline. This study examines the potential effects of market pressures and the perception of wealth on human consumption patterns of Podocnemis unifilis and P. expansa. The hypotheses tested were: 1) there is greater market consumption of turtle protein closer to market and greater subsistence consumption of turtle protein farther away; 2) there is a negative relationship between wealth and turtle protein sale/trade such that as personal wealth increases, the consumption of turtle protein decreases. Findings suggest proximity to market does not lead to greater turtle consumption and the relationship between turtle consumption and perception of wealth is negative. The fi ndings also suggest that improved roads into communities may reduce pressure on the turtles; poorest households pose the greatest risks to turtle abundance; and culturally-specific attitudes must be addressed for effective turtle conservation and management.
Conversion of Interleukin-13 into a High Affinity Agonist by a Single Amino Acid Substitution*

We created a novel mutated form of human interleukin-13 (IL-13) in which a positively charged arginine (R) at position 112 was substituted to a negatively charged aspartic acid (D). This mutant, termed IL-13R112D, was expressed in Escherichia coli and purified to near homogeneity. IL-13R112D was found to be a potent IL-13 agonist with 5–10-fold improved binding affinity to IL-13 receptors compared with wild-type IL-13 (wtIL-13). The conclusion of IL-13 agonist activity was drawn on the basis of approximately 10-fold improved activity over wtIL-13 in several assays: (a) inhibition of CD14 expression in primary monocytes; (b) proliferation of TF-1 and B9 cell lines; and (c) activation of STAT6 in Epstein-Barr virus-immortalized B cells, primary monocytes, and THP-1 monocytic cell line. Furthermore, mutant IL-13R112D neutralized the cytotoxic activity of a chimeric fusion protein composed of wtIL-13 and a Pseudomonasexotoxin A (IL-13-PE38) approximately 10 times better than wtIL-13. Based on these results, it was concluded that IL-13R112D interacts with much stronger affinity than wtIL-13 on all cell types tested and that Arg-112 plays an important role in the interaction with its receptors (IL-13R). Thus, these results suggest that IL-13R112D may be a useful ligand for the study of IL-13 interaction with its receptors or, alternatively, in designing specific targeted agents for IL-13R-positive malignancies.
Channel-optimized vector quantizer design for compressed sensing measurements

We consider vector-quantized (VQ) transmission of compressed sensing (CS) measurements over noisy channels. Adopting mean-square error (MSE) criterion to measure the distortion between a sparse vector and its reconstruction, we derive channel-optimized quantization principles for encoding CS measurement vector and reconstructing sparse source vector. The resulting necessary optimal conditions are used to develop an algorithm for training channel-optimized vector quantization (COVQ) of CS measurements by taking the end-to-end distortion measure into account.
The Role of Oracy in Developing Comprehension in Spanish‐Speaking English Language Learners

Components of first-grade intervention programs that addressed oral language and listening comprehension instruction within an intensive literacy intervention for native Spanish-speaking students struggling with reading difficulties are described. Findings for the intervention are based on 4 large-scale experimental studies (published elsewhere) in which the intervention was provided to struggling first-grade English language learners (ELLs) in the same language as the core reading instruction (Spanish or English). Interventions taught children the alphabetic principle with letter–sound correspondences and how to read words quickly and accurately as well as providing practices that enhanced the language skills needed to understand word and text meaning. Thus, explicit instruction was provided in oral language, phonemic awareness, alphabetic knowledge, fluency, vocabulary, and comprehension strategies. The essential features of the intervention that addressed oral language were a shared storybook reading routine in addition to enhanced language acquisition instruction. Findings indicate that students in the intervention made progress in the areas of phonological awareness, letter–sound identification, word attack, and comprehension skills. Our intervention studies empirically informs us on the instructional components of effective reading and oral language interventions for Spanish-speaking ELLs who are at risk for reading difficulties.
The spectra of wrapped butterfly digraphs

The knowledge of the spectrum of a (di)graph is relevant for estimating some of its structural properties, which provide information on the topological and communication properties of the corresponding networks. Among these properties, we have, for instance, edge‐expansion and node‐expansion, bisection width, diameter, maximum cut, connectivity, and partitions. In this paper, we determine the complete spectra (eigenvalues and multiplicities) of wrapped butterfly digraphs. © 2003 Wiley Periodicals, Inc.
MR diffusion tensor imaging documented arcuate fasciculus lesion in a patient with normal repetition performance

Background: The pathophysiology of the syndrome of conduction aphasia has been thought to involve a disconnection between posterior and anterior language areas. The arcuate fasciculus has been one of the principal candidates for an anatomical link between Wernicke's and Broca's area, but direct evidence for its involvement in conduction aphasia has been difficult to obtain. Aims: The purpose of this study was to examine white matter tract integrity, using the novel magnetic resonance imaging technique of diffusion tensor imaging, in a patient with transcortical aphasia. Methods & Procedures: A case study of a 55-year-old, right-handed man with aphasia following a left hemisphere stroke is reported. The patient's language performance was assessed with the Boston Diagnostic Aphasia Examination twice: at 10 days and at 2 years after his stroke. An MR diffusion tensor imaging study was obtained approximately 2 years after his stroke using the 1.5 T Phillips Gyroscan NT system. White matter fibre tracts maps were reconstructed using the “FACT” algorithm. Outcomes and Results: Ten days after his stroke, the patient had a non-fluent aphasia with marked impairment of both auditory comprehension and spontaneous speech. However, repetition was relatively intact. By 2 years, when the MR diffusion tensor imaging study was performed, repetition was completely normal and the patient had only subtle deficits in areas of naming and auditory comprehension. The MR diffusion tensor imaging study revealed a lesion of the dominant hemisphere arcuate fasciculus. Conclusions: This study documents normal repetition performance in a patient who on subsequent MR diffusion tensor imaging was found to have a lesion involving the dominant hemisphere arcuate fasciculus lesion. This case adds to previously published cases of normal repetition performance despite a documented lesion of the arcuate fasciculus, and thus further challenges the traditional model of conduction aphasia invoking a critical role of this white matter tract. Our case also suggests that MR diffusion tensor imaging may be a potentially useful technique to evaluate regional involvement of specific white matter tract projections in patients with aphasia.
Incidental Non-Cardiac Findings of a Coronary Angiography with a 128-Slice Multi-Detector CT Scanner: Should We Only Concentrate on the Heart?

Objective To evaluate the spectrum, prevalence, and significance of incidental non-cardiac findings (INCF) in patients referred for a non-invasive coronary angiography using a 128-slice multi-detector CT (MDCT). Materials and Methods The study subjects included 1,044 patients; 774 males (mean age, 59.9 years) and 270 females (mean age, 63 years), referred for a coronary CT angiography on a 128-slice MDCT scanner. The scans were acquired from the level of the carina to just below the diaphragm. To evaluate INCFs, images were reconstructed with a large field of view (> 300 mm) covering the entire thorax. Images were reviewed in the axial, coronal, and sagittal planes, using the mediastinal, lung, and bone windows. The INCFs were classified as severe, indeterminate, and mild, based on their clinical importance, and as thoracic or abdominal based on their locations. Results Incidental non-cardiac findings were detected in 56% of patients (588 of 1,044), including 435 males (mean age, 65.6 years) and 153 females (mean age, 67.9 years). A total of 729 INCFs were observed: 459 (63%) mild (58% thoracic, 43% abdominal), 96 (13%) indeterminate (95% thoracic, 5% abdominal), and 174 (24%) severe (87% thoracic, 13% abdominal). The prevalence of severe INCFs was 15%. Two severe INCFs were histologically verified as lung cancers. Conclusion The 128-slice MDCT coronary angiography, in addition to cardiac imaging, can provide important information on the pathology of the chest and upper abdomen. The presence of severe INCFs is not rare, especially in the thorax. Therefore, all organs in the scan should be thoroughly evaluated in daily clinical practice.
A Low-Power Process-Scalable Super-Heterodyne Receiver With Integrated High-$Q$  Filters

A super-heterodyne receiver utilizing integrated high-Q filters to condition the desired signal to be digitized by a bandpass ADC at an IF of 110 MHz achieves a NF of 2.8 dB and an IIP3 of -8.4 dBm. The conventional M-phase filter is developed to a new form of high-Q filter that is centered at sum or difference of two clocks. The M-phase filter is also evolved to take two quadrature inputs to perform image rejection, while exhibiting a high-Q bandpass response with desired signal located in the center. Built of inverters, switches, and MOS capacitors, the receiver follows technology scaling and is reconfigurable through a clock. The receiver including the dividers and LO path draws 12 mA of battery current and occupies 0.76 mm2 in 65-nm CMOS.
British Trials of Irish Nationalist Defendants: The Quality of Justice Strained

In what came to be controversial cases in the 1970s, British courts convicted individuals involved with IRA bombing campaigns and sent them to prison. The Guildford Four, Maquire Seven, and Birmingham Six were all convicted with faulty evidence and/or coerced confessions. Obtaining convictions for the bombings was important for the British government and British public opinion, since the guilty persons were caught and punished. There are few indications, however, that the government as a matter of policy decided to convict and imprison innocent people in order to mollify the public and achieve other political objectives. The original convictions were miscarriages of justice but not government policy. The delay in rectifying the original convictions, however, displayed more concern about potential negative effects for the political system if judicial errors were admitted.
Health Behavior Theory in Physical Activity Game Apps: A Content Analysis

Background Physical activity games developed for a mobile phone platform are becoming increasingly popular, yet little is known about their content or inclusion of health behavior theory (HBT). Objective The objective of our study was to quantify elements of HBT in physical activity games developed for mobile phones and to assess the relationship between theoretical constructs and various app features. Methods We conducted an analysis of exercise and physical activity game apps in the Apple App Store in the fall of 2014. A total of 52 apps were identified and rated for inclusion of health behavior theoretical constructs using an established theory-based rubric. Each app was coded for 100 theoretical items, containing 5 questions for 20 different constructs. Possible total theory scores ranged from 0 to 100. Descriptive statistics and Spearman correlations were used to describe the HBT score and association with selected app features, respectively. Results The average HBT score in the sample was 14.98 out of 100. One outlier, SuperBetter, scored higher than the other apps with a score of 76. Goal setting, self-monitoring, and self-reward were the most-reported constructs found in the sample. There was no association between either app price and theory score (P=.5074), or number of gamification elements and theory score (P=.5010). However, Superbetter, with the highest HBT score, was also the most expensive app. Conclusions There are few content analyses of serious games for health, but a comparison between these findings and previous content analyses of non-game health apps indicates that physical activity mobile phone games demonstrate higher levels of behavior theory. The most common theoretical constructs found in this sample are known to be efficacious elements in physical activity interventions. It is unclear, however, whether app designers consciously design physical activity mobile phone games with specific constructs in mind; it may be that games lend themselves well to inclusion of theory and any constructs found in significant levels are coincidental. Health games developed for mobile phones could be potentially used in health interventions, but collaboration between app designers and behavioral specialists is crucial. Additionally, further research is needed to better characterize mobile phone health games and the relative importance of educational elements versus gamification elements in long-term behavior change.
PATERNITY ANALYSIS IN A NATURAL POPULATION OF ASCLEPIAS EXALTATA: MULTIPLE PATERNITY, FUNCTIONAL GENDER, AND THE “POLLEN‐DONATION HYPOTHESIS”

Recently, some evolutionary biologists have argued that selection on the male component of fitness shapes the evolution of reproductive characters in angiosperms. Floral features, such as inflorescence size, that lead to increased insect visitation without a concomitant increase in seed production are viewed as adaptations to enhance the probability of fathering seeds on other plants. In tests of this “pollen donation hypothesis,” male reproductive success has usually been measured indirectly by flower production, pollinator visitation, or pollen removal. We tested the pollen donation hypothesis directly by quantifying the number of seeds sired by individual genotypes in a natural population of poke milkweed, Asclepias exaltata, in southwestern Virginia. Multiple paternity was low within fruits, a fact which allowed us to use genotypes of progeny arrays to identify a unique pollen parent for 85% of the fruits produced in the population. Seeds sired (male success) and seeds produced (female success) were significantly correlated with flower number per plant (for male success, r = 0.32, P > 0.05; for female success, r = 0.66, P > 0.001). While the number of pollinaria removed, the usual estimator of male success in milkweeds, was highly correlated with numbers of seeds sired (r = 0.47; P > 0.001), it was even more highly correlated with numbers of seeds produced (r = 0.71, P > 0.001). Analysis of functional gender indicated that plants with many flowers did not behave primarily as males. In fact, individuals with the highest total reproductive success contributed equally as males and females. Furthermore, estimates of gender based on numbers of flowers produced or pollinaria removed overestimated the number of functional males in the population. In pollen‐limited species, such as many milkweeds, proportional increases in both male and female reproductive success indicate the potential for selection to shape the evolution of large floral displays through both male and female functions.