Miracle-dz/UniFAR-FTUs huggingface dataset:
Direct Blood PCR in Combination with Nucleic Acid Lateral Flow Immunoassay for Detection of Plasmodium Species in Settings Where Malaria Is Endemic

ABSTRACT Declining malaria transmission and known difficulties with current diagnostic tools for malaria, such as microscopy and rapid diagnostic tests (RDTs) in particular at low parasite densities, still warrant the search for sensitive diagnostic tests. Molecular tests need substantial simplification before implementation in clinical settings in countries where malaria is endemic. Direct blood PCR (db-PCR), circumventing DNA extraction, to detect Plasmodium was developed and adapted to be visualized by nucleic acid lateral flow immunoassay (NALFIA). The assay was evaluated in the laboratory against samples from confirmed Sudanese patients (n = 51), returning travelers (n = 214), samples from the Dutch Blood Bank (n = 100), and in the field in Burkina Faso (n = 283) and Thailand (n = 381) on suspected malaria cases and compared to RDT and microscopy. The sensitivity and specificity of db-PCR-NALFIA compared to the initial diagnosis in the laboratory were 94.4% (95% confidence interval [CI] = 0.909 to 0.969) and 97.4% (95% CI = 0.909 to 0.969), respectively. In Burkina Faso, the sensitivity was 94.8% (95% CI = 0.88.7 to 97.9%), and the specificity was 82.4% (95% CI = 75.4 to 87.7%) compared to microscopy and 93.3% (95% CI = 87.4 to 96.7%) and 91.4% (95% CI = 85.2 to 95.3%) compared to RDT. In Thailand, the sensitivity and specificity were 93.4% (CI = 86.4 to 97.1%) and 90.9 (95% CI = 86.7 to 93.9%), respectively, compared to microscopy and 95.6% (95% CI = 88.5 to 98.6%) and 87.1% (95% CI = 82.5 to 90.6) compared to RDT. db-PCR-NALFIA is highly sensitive and specific for easy and rapid detection of Plasmodium parasites and can be easily used in countries where malaria is endemic. The inability of the device to discriminate Plasmodium species requires further investigation.
The Influence of Race, Heuristics, and Information Load on Judgments of Guilt and Innocence

This study applies the heuristic-systematic model to explore the influence of race and judicial-system heuristics on jury decision-making. In a mock-jury investigation, a 3 × 2 experimental design varied a trial description's information load (high, medium, low) and defendant's race (Caucasian, African American). Two participant groups (Caucasian, African American) judged defendant characteristics and guilt. Observations demonstrate that race and legal-system heuristics alter guilt judgments. First, although Caucasian judgments were unaffected by race, an accused African American benefited from disproportionately positive judgments by African American appraisers. Second, information load moderated heuristic influence on guilt judgments. High load strengthened the negative effect of perceived judicial-system bias on verdicts of innocence.
Abnormalising minorities. The state and expert knowledge addressing the Roma in Italy

This article expands the research on abnormalisation and the construction of social deviance of minorities. It focuses on the relationships between state practices, policies and expert knowledge addressing the Roma in Italy; it does so by first contextualising recent ethnographic findings on Turin authorities’ social inclusion practices addressing Roma within the history of national and regional policies for Roma; it then contextualises those policies within the history of expert knowledge about Roma. Unlike what other studies on abnormalisation suggest, we argue that the abnormalisation of Roma in Italy is not primarily predicated upon the idea that they are at present unfit to follow the norms of the majority; rather, it stays upon a historically rooted representation of Roma oscillating between the poles of potential re-educability and potential dangerousness. In the conclusion we encourage further comparative research on abnormalisation, especially including practices and knowledge addressing other European minorities such as the Jews.
Mechanisms of object recognition: what we have learned from pigeons

Behavioral studies of object recognition in pigeons have been conducted for 50 years, yielding a large body of data. Recent work has been directed toward synthesizing this evidence and understanding the visual, associative, and cognitive mechanisms that are involved. The outcome is that pigeons are likely to be the non-primate species for which the computational mechanisms of object recognition are best understood. Here, we review this research and suggest that a core set of mechanisms for object recognition might be present in all vertebrates, including pigeons and people, making pigeons an excellent candidate model to study the neural mechanisms of object recognition. Behavioral and computational evidence suggests that error-driven learning participates in object category learning by pigeons and people, and recent neuroscientific research suggests that the basal ganglia, which are homologous in these species, may implement error-driven learning of stimulus-response associations. Furthermore, learning of abstract category representations can be observed in pigeons and other vertebrates. Finally, there is evidence that feedforward visual processing, a central mechanism in models of object recognition in the primate ventral stream, plays a role in object recognition by pigeons. We also highlight differences between pigeons and people in object recognition abilities, and propose candidate adaptive specializations which may explain them, such as holistic face processing and rule-based category learning in primates. From a modern comparative perspective, such specializations are to be expected regardless of the model species under study. The fact that we have a good idea of which aspects of object recognition differ in people and pigeons should be seen as an advantage over other animal models. From this perspective, we suggest that there is much to learn about human object recognition from studying the “simple” brains of pigeons.
A Binary Integer Programming Model for Global Optimization of Learning Path Discovery

This paper introduces a method based on graph theory and operations research techniques to optimize learning path discovery. In this method, learning objects are considered as nodes and competencies as vertices of a learning graph. A first step consists in reducing the solution space by obtaining an induced subgraph H. In a second step, the search of an optimal learning path in H is considered as a binary integer programming problem which we propose to solve using an exact method based on the well-known branch-and-bound algorithm. The method detailed in the paper takes into account the prerequisite and gained competencies as constraints of the optimization problem by minimizing the total competencies needed to reach the learning objective.
The development of a decisional balance scale for anorexia nervosa

The purpose of this study was to develop a Decisional Balance (DB) measure of readiness for change in anorexia nervosa. A total of 246 women with anorexia nervosa completed a 60-item DB scale. A 3-factor solution provided the best fit for the DB data, which reduced the scale to 30 items. Two of these, namely Burdens and Benefits, resembled the pro and con factors found in previous research. The third factor, Functional Avoidance, was unique to the decisional balance literature; it included items reflecting the ways that anorexia nervosa provides a way to avoid dealing with aversive emotions, challenges, and responsibilities. The DB demonstrated good internal consistency and acceptable test–retest reliability. This measure could be used to help us better understand the shifts that occur as individuals with anorexia nervosa develop a desire to change. Copyright © 2002 John Wiley & Sons, Ltd and Eating Disorders Association.
Low Power Schedule Algorithm for Embedded Multimedia Applications Basing on Imagine-L Processor

The increasing high performance requirement of multimedia applications makes stream processors widely used for multimedia processing acceleration due to the powerful computation. Low power then becomes a critical challenge confronted by stream processors, especially in embedded and realtime situations. In this paper, a low power scheduling algorithm for embedded multimedia applications is proposed, and the H.264 encoding with intra-frame luma prediction is illustrated to demonstrate the schedule efficiency. As the fundamental of the scheduling algorithm, a multi-issued low power processor (Imagine-L) is first introduced which enables both DVFS, DPM techniques and multi-task parallelism. Then, a scheme which contains task mapping, V/F scaling and shutdown assignment is proposed for low power schedule. Task dependency, record dependency, task computation intensity and shutdown breakeven point are all considered in the proposed algorithm to reduce power dissipation. For experimentation a power model is built for Imagine-L processor. The H.264 encoding application is implemented by the proposed algorithm, where 66% power consumption is reduced compared with the Imagine processor.
Living alone, marital status, gender and health

Non-married people have generally been found to be less healthy than the married. It has been suggested that this difference may be brought about by the greater lack of social integration of those living alone. This hypothesis was tested by comparing the health of those living alone with those living with another person in the four non-married categories of never married, separated, divorced and widowed for women and men separately, initially controlling for age, education and income and subsequently adding five proximate indices of social integration. The person lived with was further categorized as an adult, cohabitee, child aged 4 or under, child aged 5 to 17, adult child, parent, relative or non-relative. The three indices of health were the 30-item General Health Questionnaire of psychological distress. a 15-item checklist of common physical symptoms and alcohol intake. The main differences obtained were that women living alone drank more alcohol than those cohabiting or living with a child aged 4 or under, and that widowers living alone were more psychologically distressed than those living with an adult child, even when social integration was controlled. The results suggested that living alone was not generally associated with poor health and so could not account for the difference between the married and non-married.
Simulating the physical properties of dark matter and gas inside the cosmic web

Using the results of a high-resolution, cosmological hydrodynamical re-simulation of a supercluster-like region, we investigate the physical properties of the gas located along the filaments and bridges which constitute the so-called cosmic web. First, we analyse the main characteristics of the density, temperature and velocity fields, which have quite different distributions, reflecting the complex dynamics of the structure-formation process. Then we quantify the signals which originate from the matter in the filaments by considering different observables. Inside the cosmic web, we find that the halo density is about 10-14 times larger than cosmic mean; the bremsstrahlung X-ray surface brightness reaches at most 10 -16 erg s -1 cm -2 arcmin -2 ; the Compton-y parameter due to the thermal Sunyaev-Zel'dovich effect is about 10 -6 ; the reduced shear produced by the weak lensing effect is ∼0.01-0.02. These results confirm the difficulty of an observational detection of the cosmic web. Finally, we find that projection effects of the filamentary network can affect the estimates of the properties of single clusters, increasing their X-ray luminosity by less than 10 per cent and their central Compton-y parameter by up to 30 per cent.
A Cloud of Things (CoT) Based Security for Home Area Network (HAN) in the Smart Grid

A smart grid is a power system that consists of communication infrastructure, IT systems, advanced actuators, and advanced monitoring building blocks for a smart city. The devices powered in smart homes have embedded systems in appliances. They are sensor-based and network-enabled and commonly referred to as Internet of Things (IoT). A Cloud of Things (CoT) virtualizes the IoT and provides monitoring and control. The CoT services in the home area network will enable a collection of applications that will use real-time data from these appliances. As always, security and privacy issues are prime since it involves private data from the home. In this paper, we propose a secure scheme for Home Area Network (HAN) based on CoT. The security scheme discusses how a device that is connected at a home is serviced from the CoT. Specifically, it illustrates how the security requirements are administered from the CoT and discusses a specific scheme for key management for the HAN.
Morphosyntactic and phonological constraints on negative particle variation in French-language chat discourse

ABSTRACT This study investigates the variable presence or absence of the negative morpheme ne in online French-language chat environments. The data indicate an overwhelming preference for the omission of ne in most instances of verbal negation, which corroborates previous studies of ne in everyday conversational French. VARBRUL analyses revealed four principal results: (i) subject type (i.e., noun phrase [NP], pronoun, or inferred subject) is the most influential factor; (ii) NPs favor ne presence irrespective of the conditioning factors considered in this study; (iii) the variable presence of ne is conditioned by phonological factors within the subject pronoun category; (iv) the type of second-negative present (i.e., pas vs. second-negative other than pas) influences ne retention in inferred subject environments.
Measurement of eye lens dose for Varian On-Board Imaging with different cone-beam computed tomography acquisition techniques

The objective of this work was to measure patient eye lens dose for different cone-beam computed tomography (CBCT) acquisition protocols of Varian′s On-Board Imaging (OBI) system using optically stimulated luminescence dosimeter (OSLD) and to study the variation in eye lens dose with patient geometry and distance of isocenter to the eye lens. During the experimental measurements, OSLD was placed on the patient between the eyebrows of both eyes in line of nose during CBCT image acquisition to measure eye lens doses. The eye lens dose measurements were carried out for three different cone-beam acquisition protocols (standard dose head, low-dose head [LDH], and high-quality head [HQH]) of Varian OBI. Measured doses were correlated with patient geometry and distance between isocenter and eye lens. Measured eye lens doses for standard head and HQH protocols were in the range of 1.8-3.2 mGy and 4.5-9.9 mGy, respectively. However, the measured eye lens dose for the LDH protocol was in the range of 0.3-0.7 mGy. The measured data indicate that eye lens dose to patient depends on the selected imaging protocol. It was also observed that eye lens dose does not depend on patient geometry but strongly depends on distance between eye lens and treatment field isocenter. However, undoubted advantages of imaging system should not be counterbalanced by inappropriate selection of imaging protocol, especially for very intense imaging protocol.
Site-Specific Recombination System Encoded by Toluene Catabolic Transposon Tn4651

ABSTRACT The 56-kb class II toluene catabolic transposon Tn4651 from Pseudomonas putida plasmid pWW0 is unique in that (i) its efficient resolution requires, in addition to the 0.2-kb resolution (res) site, the two gene products TnpS and TnpT and (ii) the 2.4-kb tnpT-res-tnpS region is 48 kb apart from the tnpA gene (M. Tsuda, K.-I. Minegishi, and T. Iino, J. Bacteriol. 171:1386-1393, 1989). Detailed analysis of the 2.4-kb region revealed that the tnpS and tnpT genes encoding the putative 323- and 332-amino-acid proteins, respectively, were transcribed divergently with an overlapping 59-bp sequence in the 203-bp res site. The motifs (the R-H-R-Y tetrad in domains I and II with proper spacing) commonly conserved in the integrase family of site-specific recombinases were found in TnpS. In contrast, TnpT did not show any significant amino acid sequence homology to the other proteins that are directly or indirectly involved in recombination. Analysis of site-specific recombination under the Escherichia coli recA cells indicated that (i) the site-specific resolution between the two copies of the res site on a single molecule was catalyzed by TnpS, (ii) the functional res site was located within a 95-bp segment, and (iii) TnpT appeared to have the role of enhancing the site-specific resolution. It was also found that TnpS catalyzed the site-specific recombination between the res sites located at two different molecules to form a cointegrate molecule. Site-specific mutagenesis of the conserved tyrosine residue in TnpS led to the loss of both the resolution and the integration activities, indicating that such a residue took part in both types of recombination.
Location-based burst detection algorithm for georeferenced document streams based on user's moving direction

Nowadays with the increasing attention being paid to social media, a huge number of georeferenced documents, which include location information, are posted on social media sites. People transmit and collect information over the Internet through these georeferenced documents, which are usually related to not only personal topics but also local topics and events. Detecting topics and events in georeferenced documents is effective in geo-location applications such as marketing, tourism informatics, and recommendation systems. Burstiness is one of the simplest and most effective criteria for extracting hot topics from a document stream. In this paper, we propose a novel method, which extends Klenberg's burst detection algorithm, for detecting location-based bursts in georeferenced documents by considering the user's moving direction. To evaluate the proposed burst detection algorithm, we used crawling tweets posted on the Twitter site. The experimental results show that our method can detect location-based bursts by considering user's moving direction.
Rigorous Treatment of Multispecies Multimode Ligand-Receptor Interactions in 3D-QSAR: CoMFA Analysis of Thyroxine Analogs Binding to Transthyretin

For a rigorous analysis of the receptor-ligand binding, speciation of the ligands caused by ionization, tautomerism, covalent hydration, and dynamic stereoisomerism needs to be considered. Each species may bind in several orientations or conformations (modes), especially for flexible ligands and receptors. A thermodynamic description of the multispecies (MS), multimode (MM) binding events shows that the overall association constant is equal to the weighted sum of the sums of microscopic association constants of individual modes for each species, with the weights given by the unbound fractions of individual species. This expression is a prerequisite for a precise quantitative characterization of the ligand-receptor interactions in both structure-based and ligand-based structure-activity analyses. We have implemented the MS-MM correlation expression into the comparative molecular field analysis (CoMFA), which deduces a map of the binding site from structures and binding affinities of a ligand set, in the absence of experimental structural information on the receptor. The MS-MM CoMFA approach was applied to published data for binding to transthyretin of 28 thyroxine analogs, each forming up to four ionization species under physiological conditions. The published X-ray structures of several analogs, exhibiting multiple binding modes, served as templates for the MS-MM superposition of thyroxine analogs. Additional modes were generated for compounds with flexible alkyl substituents, to identify bound conformations. The results demonstrate that the MS-MM modification improved predictive abilities of the CoMFA models, even for the standard procedure with MS-MM selected species and modes. The predicted prevalences of individual modes and the generated receptor site model are in reasonable agreement with the available X-ray data. The calibrated model can help in the design of inhibitors of transthyretin amyloid fibril formation.
The Aesthetics of the Internet in St. Petersburg: Why Metaphor Matters

This article proposes that the metaphors with which people imagine the Internet are more central to its political constitution than might at first be supposed. Instead of focusing on discourses of whether the Internet is a progressive force, a capitalist or anticapitalist space, digital commons or artifact of controlled interests, this article shows that metaphors of social relations themselves frame the politicization of the Internet. The way social actors are conceptualized in turn informs the senses in which a technology could be considered an object of political constitution, and the senses in which policy is a relevant mode of social engagement. An ethnographic account of uses of the Internet in St. Petersburg, Russia is presented with a view to framing Western metaphors of sociality.
Obesity and nocturnal gastro-oesophageal reflux are related to onset of asthma and respiratory symptoms

Several studies have identified obesity as a risk factor for asthma in both children and adults. An increased prevalence of asthma in subjects with gastro-oesophageal reflux (GOR) and obstructive sleep apnoea syndrome has also been reported. The aim of this investigation was to study obesity, nocturnal GOR and snoring as independent risk factors for onset of asthma and respiratory symptoms in a Nordic population. In a 5–10 yr follow-up study of the European Community Respiratory Health Survey in Iceland, Norway, Denmark, Sweden and Estonia, a postal questionnaire was sent to previous respondents. A total of 16,191 participants responded to the questionnaire. Reported onset of asthma, wheeze and night-time symptoms as well as nocturnal GOR and habitual snoring increased in prevalence along with the increase in body mass index (BMI). After adjusting for nocturnal GOR, habitual snoring and other confounders, obesity (BMI >30) remained significantly related to the onset of asthma, wheeze and night-time symptoms. Nocturnal GOR was independently related to the onset of asthma and in addition, both nocturnal GOR and habitual snoring were independently related to onset of wheeze and night-time symptoms. This study adds evidence to an independent relationship between obesity, nocturnal gastro-oesophageal reflux and habitual snoring and the onset of asthma and respiratory symptoms in adults.
The role of positive and negative affect on well-being amongst Swedish and Iranian university students

The roles of positive and negative affect in well-being were studied in two different societies, namely the Iranian and the Swedish. A total of 606 university students (296 Iranian and 310 Swedish) participated in the study. The results showed that, whereas there was no difference between Iranian and Swedish participants in their general level of life satisfaction, differences with regard to positive and negative affect were found. Swedish participants had more positive affect, whereas Iranian participants had more negative affect. In the Swedish sample, the most predictive factor of flourishing was positive affect, while there was a balance affect (between positive and negative affects) in the Iranian sample. The results are discussed from a individualistic–collectivistic perspective.