Miracle-dz/UniFAR-FTUs huggingface dataset:
Sequential pattern mining to discover relations between genes and rare diseases

Orphanet provides an international web-based knowledge portal for rare diseases including a collection of review articles. However, reviews and literature monitoring are manual. Thus, new documentation about a rare disease is a time-consuming process and automatically discovering knowledge from a large collection of texts is a crucial issue. This context represents a strong motivation to address the problem of extracting gene-rare diseases relationships from texts. In this paper, we tackle this issue with a cross-fertilization of information extraction and data mining techniques (sequential pattern mining under constraints). Experiments show the interest of the method for the documentation of rare diseases.
Molecular fluorescence, phosphorescence, and chemiluminescence spectrometry.

This review covers the approximately two-year period since our last review (A1), roughly from January 2004 through December 2005. A computer search of Chemical Abstracts provided most of the references for this review. Other citations were found through individual searches by the various authors who wrote a particular section of this review. In an effort to more effectively accomplish this goal, we have included authors who are experts in the various subtopics of this review. Coverage is limited to articles that describe new developments in the theory and practice of molecular luminescence for chemical analysis in the ultraviolet, visible, and near-infrared region. Citations may be duplicated between sections due to articles with contents that span several topics. However, in an effort to reduce the length of this review, we have attempted to limit this kind of duplication. In general, citations are limited to journal articles and usually do not include patents, proceedings, reports, and dissertations. We have tried to focus on important advances of general interest and relevance to the field of analytical rather than extensions of previous advances. was done in an effort to continue our recent attempts to significantly reduce the length of this biennial review. In we our of individual for better clarification of
Organizational Identity and Strategy: An Empirical Study of Organizational Identity's Influence on the Strategy-Making Process

Continuous change is important for organizations' survival in a changing world, and the need for stability and continuity in the form of a clear and strong corporate identity is also acknowledged to be critical for organizational success. Organizations thus face a dilemma when they engage in strategy-making—namely, how to reconcile the perpetual tension between continuity and change. Provided in this paper are empirical insights from a longitudinal study of strategy-making that addresses this critical issue. Taking the perspective of the participants, the findings explain how their organizational cognition influenced their strategy-making action and show how a strong organizational identity guided their behavior and made it difficult for them to adapt to organizational change.
Semantic network connectivity is related to vocabulary growth rate in children

Adult semantic networks show small-world structural properties that are believed to support language processing and word retrieval. The focus of this paper is to understand when these properties emerge in lexical development. We believe that they relate to the rate of word acquisition and vocabulary size. To address this, we examine the connectivity patterns of semantic networks of individual children and compare children on faster and slower vocabulary growth trajectories. The results show that small-world properties emerge early. However, children on slower growth trajectories, who are at risk for significant language delay, do not show these properties. The differences between typical and these so-called “late-talkers” persist, even when vocabulary size is equated. Late talkers’ vocabularies are not only acquired later, but also less cohesively, a fact that may relate to future language processing difficulties for these children. In brief, the results suggest that properties of network connectivity may play a role in early lexical development.
Complex Systems Models - Engineering Simulations

As part of research towards the CoSMoS unified infrastructure for modelling and simulating complex systems, we review uses of definitional and descriptive models in natural science and computing, and existing integrated platforms. From these, we identify requirements for engineering models of complex systems, and consider how some of the requirements could be met, using state-of-the-art model management and a mobile, process-oriented computing paradigm.
Estimating the Impact of Receiving a Higher Evaluation Rating on Early-Career Teacher Turnover and Its Relationship to School Context

Teacher evaluation systems have gone through widespread changes in recent years. These new systems have the potential to influence early-career teachers’ career trajectories because of their increase in rigor and ties to formal and informal consequences. In this paper, I investigate the impact of receiving a higher evaluation rating on early-career attrition and movement among districts and schools in a medium-sized state in the United States. Using a regression discontinuity design that takes advantage of the cut scores between each pair of evaluation ratings, I find that receiving a higher rating slightly increases the probability that early-career teachers will move to different districts. I do not find any effect of receiving a higher rating on the probability of a teacher leaving teaching in the state or moving among schools within a district. I find similar effects of ratings on teacher attrition and movement among schools for early-career and experienced teachers. When I apply the regression discontinuity to three cut scores simultaneously, I find that early-career teachers who received a higher evaluation rating were more likely to move among districts than experienced teachers who received a higher rating. Additionally, I do not detect any differences in the impact of teacher evaluation ratings on early-career teacher turnover based on school context. Finally, while on average early-career teachers moved to schools that were similar to those they left, I find that teachers who received higher ratings were more likely to move to schools with slightly higher percentages of low-income and non-white students.
Parallel guiding virtual fixtures: control and stability

Guiding virtual fixtures have been proposed as a method for human-robot co-manipulation. They constrain the motion of the robot to task-relevant trajectories, which enables the human to execute the task more efficiently, accurately and/or ergonomically. When sequences of different tasks must be solved, multiple guiding virtual fixtures are required, and the appropriate guide for the current task must be detected automatically. To this end, we propose a novel control scheme for multiple guiding virtual fixtures that are active in parallel. Furthermore, we determine under which conditions using multiple fixtures is stable. Finally, we perform a pilot study for a real-world application with a humanoid robot.
Youth Protests against Education Privatization Reforms in Post-Soviet States

This article examines youth protests against education privatization in the post-Soviet countries of Latvia, Russia, and Ukraine. Drawing on a sample of online sources and scholarly articles, this study uses critical discourse analysis and visual methodologies to examine why and how post-Soviet university students have organized to protest against education privatization reforms. The study also critically analyzes visual and discursive representations of youth protests by government officials, mass media, and academia in the post-Soviet education space. The study reveals that while student protesters are deeply concerned about the future of public education, the messages (and images) generated by youth protesters are reappropriated in various ways by mass media, often beyond the control of protesters themselves.
TIME-AWARE SOCIAL RECOMMENDATION BASED ON USER FEEDBACK

Context information such as time, social relationsh ip and user feedback information can be exploited t o improve the quality of recommendation. However, mos t collaborative filtering based methods ignore this kind of information in social recommendation. In th is paper, we propose a time-aware social recommendation method based on user feedback for to p-k item recommendation in social networks. Our method incorporates the temporal factors by introdu cing a time weight function, which models the decay of user interest. Moreover, our method considers the u s r positive feedback and negative feedback information, as well as the social relationship inf ormation for recommendation. Empirical analysis an d experiments are conducted in Sina Weibo, one of the most popular social network sites in China. The experimental results demonstrate that our method ou tperforms the collaborative filtering method in ter ms of MAP for top-k item recommendation.
Professor John Eggleston Memorial Lecture - Assessing design innovation: The famous five and the terrible two

Technology Education Research Unit, Goldsmiths University of London The paradigm debate [n recent months Andy Breckon our recenty departed and much missed chief executivehas provoked a debate about the current condition of design and technology. Are we doing the right things? Are we aiming at the right targets? Do we need to update and upgrade our ideas of what design and technology should be?
Death Ligand TRAIL Induces No Apoptosis but Inhibits Activation of Human (Auto)antigen-Specific T Cells1

TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily, induces apoptosis in susceptible cells, which can be both malignant and nontransformed. Despite homologies among the death ligands, there are great differences between the TRAIL system on the one hand and the TNF and CD95 systems on the other hand. In particular, TRAIL-induced apoptosis differs between rodents and man. Studies on animal models of autoimmune diseases suggested an influence of TRAIL on T cell growth and effector functions. Because we previously demonstrated that TRAIL does not induce apoptosis in human (auto)antigen-specific T cells, we now asked whether TRAIL exhibits other immunoregulatory properties in these cells. Active TRAIL inhibited calcium influx through store-operated calcium release-activated calcium channels, IFN-γ/IL-4 production, and proliferation. These effects were independent of APC, Ag specificity, and Th differentiation, and no differences were detected between healthy donors and multiple sclerosis patients. TRAIL affected neither the expression of the cell cycling inhibitor p27Kip1 nor the capacity of T cells to produce IL-2 upon Ag rechallenge, indicating that signaling via TRAIL receptor does not induce T cell anergy. Instead, the TRAIL-induced hypoproliferation could be attributed to the down-regulation of the cyclin-dependent kinase 4, indicating a G1 arrest of the cell cycle. Thus, although it does not contribute to mechanisms of peripheral T cell tolerance such as clonal anergy or deletion by apoptosis, TRAIL can directly inhibit activation of human T cells via blockade of calcium influx.
Identifying peers to form an effective team in a project-based course innovative practice

Science and Education is an elective course for all undergraduates of Universidad de los Andes, a Colombian institution. This course is designed to promote a scientific mindset while learning how to teach STEM concepts. During the third week of the course, students must identify teammates for a 3-month project. Because the team lasts almost the entire term, it is important to be able to identify complementary teammates and work effectively. To address that need, an in-class activity called Speed Grouping was designed. This study aims to analyze what are the students' reflections about the Speed Grouping activity and their process of forming teams for the project. The students' perceptions about the usefulness of the Speed Grouping activity for working effectively as a team was revised. To address this goal, a qualitative thematic analysis was conducted, using students' reflective papers based on their own diary entries about teamwork. Categories emerged from data and were linked to effective teamwork literature to analyze the level of success in forming groups for the project. The results of the thematic analysis showed that the Speed Grouping activity promoted peer selection for group effectiveness. In addition, reflections show a positive anticipation for teamwork during the project, highlighting the importance of interaction, team outcome, peers' personality and abilities, and articulation of team members.
Survey of access control models for cloud based real-time applications

Cloud computing is one of the prominent technologies in this century. Due to its various features and capabilities, it attracted a large population towards it. Cloud is a huge pool of resources which is owned and managed by the third parties collectively called as Cloud Service Provider (CSP). The users enjoy the freedom in using the resources at their ease that has been deployed in the cloud. Irrespective of the place, the computing resources could be accessed by the user via internet services. It also provides the advantage of using the cloud services as per end user's demand. As each coin has two faces, the cloud computing strategy also has an evil face. The major drawback lies in securing the sensitive information and preserving the privacy details. To throw light upon this fact and to overcome this, a new terminology has been emerged in the cloud environment called "Access Control". This Access Control has travelled a long way in recent times. Among many techniques of access control, DAC, MAC, RBAC and ABAC prove to clear the security issues prevailed in cloud storage environment. Today's business market is totally depends on real-time applications and E-shopping applications as the country's major economy is derived from it. Many eminent researches have been carried out by the scientists to apply the access control in application scenario. In this paper, we have analysed the major business applications, the security issues currently faced by them and we have suggested which of the access control models would be efficient to make them more secure and enjoyable to use.
Dialectological, Computational and Interpretative Aspects

1 Description of the project and personal reminiscences This project – the first computer developed linguistic atlas of England – has been a rather long time in the making. Its database is that provided by the Survey of English Dialects (SED), a nationwide survey conducted in England in the 1950s and 1960s and published in narrow phonetic transcriptions in four regional volumes, each in three parts (cf Orton et al 1962–1971; for a description of the survey see Viereck 1988). Our intentions had been overly ambitious in the beginning as we wanted to include phonetics, too. At that time the scanner had not yet been invented with which even today the error rate is quite high when narrow phonetic transcriptions and diacritics are involved. In those days it would have been necessary to devise a key for coding even minute phonetic differences. While this would surely have been possible, the task of using the phonetic key correctly and of putting the enormous amount of information on endless sheets of paper to be then punched on cards was too formidable to be attempted. The computer stone age is pretty recent; progress in computational dialectology has been unbelievably fast. As a quantification of the data and a dictionary had originally also been envisaged, phonetic transcriptions had to be transformed into normal orthography, too 1. This transformation of pronunciations into spellings proved very difficult indeed 2. In addition, even without phonetics, coding is a rather monotonous business and one has to reckon with the human factor. In the course of our work I was often reminded of Roger Shuy's remark that he had been given a handsome sum of money for coding syntactic data. One should think that this is not too difficult a task, but when the work had been completed, Shuy had to throw everything 79
CRACK: A CRITIQUING APPROACH TO COOPERATIVE KITCHEN DESIGN

Human problem-domain communication and cooperative problem solving are two enabling con­ ditions that allow users, who are not computer experts, to use computers for their own purposes. Computer-based critics, a specific class of intelligent support systems, are most effective if they are embedded in a framework defmed by human problem-domain communication and coopera­ tive problem solving.
Proteome Analysis of Grain Filling and Seed Maturation in Barley1

In monocotyledonous plants, the process of seed development involves the deposition of reserves in the starchy endosperm and development of the embryo and aleurone layer. The final stages of seed development are accompanied by an increase in desiccation tolerance and drying out of the mature seed. We have used two-dimensional gel electrophoresis for a time-resolved study of the changes in proteins that occur during seed development in barley (Hordeum vulgare). About 1,000 low-salt extractable protein spots could be resolved on the two-dimensional gels. Protein spots were divided into six categories according to the timing of appearance or disappearance during the 5-week period of comparison. Nineteen different proteins or protein fragments in 36 selected spots were identified by matrix-assisted laser-desorption ionization time of flight mass spectrometry (MS) or nano-electrospray tandem MS/MS. Some proteins were present throughout development (for example, cytosolic malate dehydrogenase), whereas others were associated with the early grain filling (ascorbate peroxidase) or desiccation (Cor14b) stages. Most noticeably, the development process is characterized by an accumulation of low-M r α-amylase/trypsin inhibitors, serine protease inhibitors, and enzymes involved in protection against oxidative stress. We present examples of proteins not previously experimentally observed, differential extractability of thiol-bound proteins, and possible allele-specific spot variation. Our results both confirm and expand on knowledge gained from previous analyses of individual proteins involved in grain filling and maturation.
Sample-based Zero-Gradient-Sum distributed consensus optimization of multi-agent systems

This paper addresses distributed convex optimization problem for continuous-time multi-agent systems via sampled control over undirected networks. A novel sampled-based Zero-Gradient-Sum (ZGS) distributed optimization algorithm is proposed which are induced from ZGS algorithm by using periodic sampling technology and zero-order hold circuit. A new Lyapunov-based approach is used to give convergence analysis of the proposed algorithm. By choosing proper sampling period and gain parameter, we prove that each agent of the system converges asymptotically to the unknown optimal value of the cost function. A simulation example is given to illustrate the effectiveness of the algorithm proposed in this paper.
Polyoma Viral DNA Replicated as a Nucleoprotein Complex in Close Association with the Host Cell Chromatin

Polyoma viral DNA is shown to be replicated in close association with the mouse cell chromatin. Two virus-specific nucleoprotein complexes, designated complex A and B, can be dissociated from the isolated chromatin by gentle homogenization in 0.5 M NaCl. Complex A contains only replicating polyoma (Py) DNA whereas complex B contains only mature Py DNA I. The results show, furthermore, that complex A, containing viral DNA in different stages of replication, and complex B are both nucleoproteins with the same buoyant density. The data presently available suggest that newly synthesized stretches of Py DNA are immediately complexed with mouse cell histones and that complex B becomes the “core” of progeny Py virions. These results suggested that Py-induced replication of the mouse cell chromatin may be necessary to provide replicating Py DNA with histones.
Consequences of Increments in Cognitive Structure for Attentional Automatization, the Experience of Boredom, and Engagement in Egocentric, Hyperdynamic, Interest-Generating Behaviors: A Developmental Psychophysiologic Approach

an obsolete set of assumptions culled from 17th century scientific and philosophical thought (2) uncritical acceptance of the orthodox Western paradigm by the majority of Westerners over the past millennia has brought man and the planet to its current state of ecological unsustainability and to crises on political, economic, social, and spiritual fronts, and (3) the trajectory of the current crises can be deflected by Western man's adherence to a more valid paradigm synthesized from core premises of perceptual-cognitive developmental psychology and psychophysiology conjoined to the core assumptions of systems, information, and control theory.
Abnormalities in the Polysomnographic, Adenosine and Metabolic Response to Sleep Deprivation in an Animal Model of Hyperammonemia

Patients with liver cirrhosis can develop hyperammonemia and hepatic encephalopathy (HE), accompanied by pronounced daytime sleepiness. Previous studies with healthy volunteers show that experimental increase in blood ammonium levels increases sleepiness and slows the waking electroencephalogram. As ammonium increases adenosine levels in vitro, and adenosine is a known regulator of sleep/wake homeostasis, we hypothesized that the sleepiness-inducing effect of ammonium is mediated by adenosine. Eight adult male Wistar rats were fed with an ammonium-enriched diet for 4 weeks; eight rats on standard diet served as controls. Each animal was implanted with electroencephalography/electromyography (EEG/EMG) electrodes and a microdialysis probe. Sleep EEG recording and cerebral microdialysis were carried out at baseline and after 6 h of sleep deprivation. Adenosine and metabolite levels were measured by high-performance liquid chromatography (HPLC) and targeted LC/MS metabolomics, respectively. Baseline adenosine and metabolite levels (12 of 16 amino acids, taurine, t4-hydroxy-proline, and acetylcarnitine) were lower in hyperammonemic animals, while putrescine was higher. After sleep deprivation, hyperammonemic animals exhibited a larger increase in adenosine levels, and a number of metabolites showed a different time-course in the two groups. In both groups the recovery period was characterized by a significant decrease in wakefulness/increase in NREM and REM sleep. However, while control animals exhibited a gradual compensatory effect, hyperammonemic animals showed a significantly shorter recovery phase. In conclusion, the adenosine/metabolite/EEG response to sleep deprivation was modulated by hyperammonemia, suggesting that ammonia affects homeostatic sleep regulation and its metabolic correlates.
A Model Selection Approach for Expression Quantitative Trait Loci (eQTL) Mapping

Identifying the genetic basis of complex traits remains an important and challenging problem with the potential to affect a broad range of biological endeavors. A number of statistical methods are available for mapping quantitative trait loci (QTL), but their application to high-throughput phenotypes has been limited as most require user input and interaction. Recently, methods have been developed specifically for expression QTL (eQTL) mapping, but they too are limited in that they do not allow for interactions and QTL of moderate effect. We here propose an automated model-selection-based approach that identifies multiple eQTL in experimental populations, allowing for eQTL of moderate effect and interactions. Output can be used to identify groups of transcripts that are likely coregulated, as demonstrated in a study of diabetes in mouse.