Miracle-dz/UniFAR-FTUs huggingface dataset:
The landscape of alternative splicing in cervical squamous cell carcinoma

Background Alternative splicing (AS) is a key regulatory mechanism in protein synthesis and proteome diversity. In this study, we identified alternative splicing events in four pairs of cervical squamous cell carcinoma (CSCC) and adjacent nontumor tissues using RNA sequencing. Methods The transcripts of the four paired samples were thoroughly analyzed by RNA sequencing. SpliceMap software was used to detect the splicing junctions. Kyoto Encyclopedia of Genes and Genomes pathway analysis was conducted to detect the alternative spliced genes-related signal pathways. The alternative spliced genes were validated by reverse transcription-polymerase chain reaction (RT-PCR). Results There were 35 common alternative spliced genes in the four CSCC samples; they were novel and CSCC specific. Sixteen pathways were significantly enriched (P<0.05). One novel 5′AS site in the KLHDC7B gene, encoding kelch domain-containing 7B, and an exon-skipping site in the SYCP2 gene, encoding synaptonemal complex 2, were validated by RT-PCR. The KLHDC7B gene with 5′AS was found in 67.5% (27/40) of CSCC samples and was significantly related with cellular differentiation and tumor size. The exon-skipping site of the SYCP2 gene was found in 35.0% (14/40) of CSCC samples and was significantly related with depth of cervical invasion. Conclusion The KLHDC7B and the SYCP2 genes with alternative spliced events might be involved in the development and progression of CSCC and could be used as biomarkers in the diagnosis and prognosis of CSCC.
A fractal-based printed slot antenna for multi-band wireless applications

Fractal geometries have shown to be attractive for antenna designers because of the unique features they ofier. In this paper, a printed fractal based slot antenna has been introduced to be used in multi-band wireless applications. The slot structure of the proposed antenna is of an octagonal shape with a Koch fractal curve of the second iteration is applied on each of its sides. The slot structure has been etched on the ground plane of a substrate with relative permittivity of 4.4 and 1.6mm thickness. On the reverse side of the substrate, a 50ohm microstrip line feed has been etched. To enhance the coupling with the slot, the feed line has been loaded with a circular stub with embedded complementary circular split ring resonator. Based on the lowest resonant frequency, it has been found that the largest dimension of the proposed antenna slot structure is less than half the guided wavelength. Parametric study shows that the resulting antenna ofiers a multi-band behavior with enhanced gain and fractional bandwidths, besides the reasonable radiation characteristics throughout the resonating bands. With appropriate dimension scaling, the proposed antenna could be a suitable candidate for use in a wide variety of multi functions wireless applications.
Changes in physical activity and related functional and disability levels in the first six months after stroke: a longitudinal follow-up study.

OBJECTIVE To investigate how physical activity changes over the first 6 months after stroke, and how activity is related to function. DESIGN A longitudinal study with an initial assessment within 14 days after stroke (in hospital) and follow-up assessments 1, 3 and 6 months later (in-patient rehabilitation or at home). SUBJECTS Patients with acute stroke. METHODS An accelerometer with a switch tilt was used to measure activity over a period of 24 h on each occasion. The Barthel Index (BI) and Berg Balance Scale (BBS) were applied as functional measures. RESULTS A total of 28 out of 44 recruited patients were included in the analysis (15 men (53.6%), mean age 79 years). The median time in the upright position increased from 92 min at baseline to 144 min 6 months later. A generalized least-square regression models showed that time in the upright position increased by 2.0 min for every day from baseline to 1 month later (p = 0.003). A single point increase on the BBS was associated with an extra 4.3 min in the upright position (p < 0.001), while a single point increase on the BI was associated with an extra 2.1 min in the upright position (p < 0.001). CONCLUSION Activity levels are very low during the first 6 months after stroke. However, time in the upright position was found to increase as function improved.
Automatic Summarization of Corporate Disclosures

Managers often provide summaries of key disclosures, such as earnings releases and MD&A. Manager-provided summaries may, however, be prone to bias in tone and content. In contrast, automatic, algorithm-based summaries have the potential to provide useful summary information with less bias than management summaries. This paper investigates characteristics of management and automatic summaries for corporate disclosures and the effect of summaries on investors’ judgments. Specifically, we conduct three experiments to investigate how automatic summaries compare to management summaries on several dimensions (e.g., usefulness, bias), and how summaries affect investor information processing, beliefs about firm fundamentals (e.g., performance, risk), and valuation judgments. Our results suggest that automatic summaries compare favorably to management summaries for earnings releases, but fare less well for MD&A. Further, investors who receive an earnings release accompanied by an automatic summary arrive at lower valuation judgments, and are more confident in those judgments, compared to investors who receive the same earnings release with a management summary. Our findings provide input to recent discussions by policy makers on the use of summaries for corporate disclosures.
Defining and Computing Least Common Subsumers in RDF

Several application scenarios in the Web of Data share the need to identify the commonalities between a pair of RDF źresources. Motivated by such needs, we propose the definition and the computation of Least Common Subsumers (LCSs) in RDF. To this aim, we provide some original and fundamental reformulations, to deal with the peculiarities of RDF. First, we adapt a few definitions from Graph Theory to paths and connectedness in RDF-graphs. Second, we define rootedRDF-graphs ( r -graphs), in order to focus on a particular resource inside an RDF-graph. Third, we change the definitions of LCSs originally set up for Description Logics to r -graphs. According to the above reformulations, we investigate the computational properties of LCS in RDF, and find a polynomial-time characterization using a form of graph composition. This result remarkably distinguishes LCSs from Entailment in RDF, which is an NP-complete graph matching problem. We then devise algorithms for computing an LCS. A prototypical implementation works as a proof-of-concept for the whole approach in three application scenarios, and shows usefulness and feasibility of our proposal. Most of our examples are taken directly from real datasets, and are fully replicable thanks to the fact that the choice about which triples are selected for the computation is made explicit and flexible.
Characterization of Interrogative Sentences in Filipino Speech

This paper presents an attempt to experimentally find the general characteristics of interrogatives in Filipino speech in terms of pitch, duration and intensity patterns. The speech corpus developed in this study consisted of recordings of 275 interrogative sentences of different types uttered by 88 individuals. Analysis showed that out of the 5 different types of interrogatives considered, only the yes-no type exhibits a rising intonation towards the end of the sentence. Another important observation from the experiments was the existence of duration lengthening pattern on either the penultimate or the final syllable of the sentence. Although intensity patterns do not show a strongly generalizable result, a minor finding was that the interrogative particle ‘ba’ often receives the highest intensity throughout the construction.
Dynamic Herding Behavior in Pacific-Basin Markets: Evidence and Implications

This study examines investor herding behavior in Pacific-Basin equity markets. Results indicate that the level of herding is time-varying, and is present in both rising and falling markets. It is positively related to stock market performance, but negatively related to market volatility. Herding estimates across markets are positively correlated, signifying comovement of herding behavior in the region. The findings suggest that tests for herding should consider its dynamic behavior.
Retargetable automatic generation of compound instructions for CGRA based reconfigurable processor applications

Reconfigurable processors such as SRP (Samsung Reconfigurable Processors) have become increasingly important, which enables just enough flexibility of accepting software solutions and providing application specific hardware configurability for faster time-to-market, lower development cost and higher performance while maintaining lower energy consumption and area. The reconfigurable processor compilation framework supports wide range of architectures through architecture description template for different domains of applications such as image processing, multimedia, video, and graphics. These architectures support several domain specific compound instructions (also called as intrinsics), which are computationally efficient when compared to the set of general instructions in the processor. Application developers have to use these intrinsics in their programs according to the architecture, which can result very inefficient usage, tedious and more error-prone. More-over, the intrinsics provided by the architecture need constant reference to the intrinsics file during development. In this paper, we propose a retargetable novel methodology for the automatic generation of compound instructions for a given architecture and application source code at compile time. Our approach is able to consider ~75% of total intrinsics in the architectures with the success rate of > 90% in identifying the intrinsics in the benchmarks such as AVC OpenGL Full Engine and OpenGL Vector benchmarks.
ELiRF: A SVM Approach for SA tasks in Twitter at SemEval-2015

This paper describes our participation at tasks 10 (sub-task B, Message Polarity Classiﬁca-tion) and 11 task (Sentiment Analysis of Fig-urative Language in Twitter) of Semeval2015. We describe the Support Vector Machine sys-tem we used in this competition. We also present the relevant feature set that we take into account in our models. Finally, we show the results we obtained in this competition and some conclusions.
2D cubic spline implementation for concurrent dual-band system

This paper presents a 2D cubic-spline (2D C-spline) implementation of digital predistortion (DPD) for the linearization of power amplifier (PA) used in dual band transmitters. The implementation uses a 2D look up table (2D-LUT) for storing the coefficients of the 2D C-spline. The transmitted signals are assumed to be sufficiently spaced wide apart so that only the in-band distortion in both the channels need to be accounted for. The frequency selective technique is used to implement the DPD in each band as it reduces the sampling frequency requirement for the analog to digital converters (ADC) and digital to analog converters (DAC) used in the transmit and feedback paths. An FPGA testbench integrating the concurrent dual band RF system is utilized to verify the linearization performance of the 2D C-spline predistorter. The linearization of two wideband code division multiple access (WCDMA) signals which are 310 MHz apart is investigated. The experimental results shows that the intermodulation distortion products are reduced by 25 dBc for a 10 W dual-band PA.
Effects of Peroxide-Based Contact Lens–Disinfecting Systems on Human Corneal Epithelial Cells In Vitro

Objective: To evaluate the effects of residual hydrogen peroxide (H2O2) in neutralized H2O2-based contact lens-disinfecting solutions on morphology, viability, and barrier function of monolayer and stratified human corneal-limbal epithelial (HCLE) cells. Methods: Cells were exposed to contact lens formulations containing 0.01% H2O2 for 10, 20, or 60 minutes. The morphology of monolayer or stratified cells was observed by microscopy. Monolayer or stratified cell viability was determined using a live/dead assay, and monolayer cell viability was quantified using flow cytometry. Effects of formulations on barrier function of stratified HCLE cells were evaluated by measuring fluorescein permeability and transepithelial resistance of cultures grown on membrane inserts. To determine the sensitivity of the tests to peroxide damage, stratified cells were also exposed to 0.01% to 0.3% H2O2 in culture medium. Results: All formulations caused swelling of monolayer cells. Formulations with or without H2O2 at pH 7.9 caused mild decreases in monolayer cell viability but did not affect viability or barrier function of stratified HCLE cells. H2O2 (≥0.1%) in culture medium caused damage without recovery to stratified HCLE cells. Conclusions: Although tests on stratified cells are capable of detecting damage caused by H2O2 in culture medium, residual H2O2 in neutralized ophthalmic formulations had no effect on stratified cells in vitro. These data suggest that H2O2, used appropriately, is a safe disinfectant. Data comparing monolayer and stratified cultures suggest that monolayers are more sensitive to peroxide damage and that the effects of neutralized formulations on stratified cells may better predict the intact corneal epithelial response.
Acetic Acid Production from Ethanol by Fluorescent Pseudomonads

Apart from the observation by Alsberg (1911) that gluconic acid is produced from glucose by Phytomonas savastanoi, the oxidative metabolism of fluorescent pseudomonads has received little attention until very recently. For the most part it has been tacitly assumed that these org Ims, by virtue of their obligately aerobic nature, carry out a complete mineralization of organic substrates (den Dooren de Jong, 1926). However, the researches of Pervozvanski (1939a, 1939b), followed by those of Lockwood et al. (1941, 1946), have established the unexpected fact that the dissimilation of monosaccharides by the majority of fluorescent pseudomonads is accompanied by the production and accumulation of the corresponding hexonic or pentonic acids in large amounts. Some strains when acting on glucose also carry the oxidation further to 2-ketogluconic acid (Pervozvanski 1939a, Lockwood et al. 1941) and a-ketoglutaric acid (Lockwood and Stodola, 1946). The failure of all previous investigators except Alsberg to observe these phenomena may be ascribed to the use of weakly buffered and insufficiently aerated media (e.g., the customary tubes of carbohydrate broth), since acidity and poor oxygen supply are both limiting factors for the transformations in question. The oxidation of monosaccharides to the corresponding -onic acids is a pattern of biochemical behavior that occurs elsewhere among bacteria, so far as is at present known, only in the Acetobacter group. Coupled with the frequently overlooked morphological similarities, it serves, as Vaughn (1942) has pointed out, to indicate a close relationship between the genera Acetobacter and Pseudomonas. Consequently it seemed of interest to find out whether the primary biochemical characteristic of the acetic acid bacteria, namely the oxidation of ethanol to acetic acid, might not also exist in the genus Pseudomonas.
User Perceptions of Security Risks in Multiple Authentications

Authentication is an everyday practice in the information economy. When people use Facebook, Google, or Twitter to log in a third-party app they perform tertiary authentications. Authentication is often the only protection users have for personal information held by platforms and third parties. This personal information and the metadata produced by people has an exchange value for platform operators. This dissertation explores people's perceptions of security and confidentiality as they perform tertiary authentications and how platform operators benefit from data generated in the process. The research design consisted of a 20-participants experiment and a policy analysis reviewing privacy and security policies of Facebook, Google, and Twitter answered these questions. What is the extent of the interplay between security and usability for platform operators that are commodifying from users' personal data through tertiary authentication; how are people managing and controlling their security and confidentiality as they perform tertiary authentications and what are the implications of those actions for users’ perception of identity and privacy, and; which conditions and variables create a perception of false security in users performing tertiary authentications, and what factors of tertiary authentication affect users’ sense of security? Through diagrammatic representations of their mental models and a questionnaire, the experiment measured how the test and control groups rated the value of their personal information after reviewing platform policies and how they managed their data when offered the chance to adjust their security and privacy settings before performing tertiary authentications. Results show that while participants tried to secure their data, they were not as aware of commodification processes. Guided by the transactional token framework used to theorize the
Text Mining to Facilitate Domain Knowledge Discovery

The high-precision observation and measurement techniques have accelerated the rapid development of geoscience research in the past decades and have pro-duced large amounts of research outputs. Many findings and discoveries were recorded in the geological literature, which is regarded as unstructured data. For these data, traditional research methods have limited functions for integrating and mining them to make knowledge discovery. Text mining based on natural language processing (NLP) provides the necessary method and technology to analyze unstructured geological literature. In this book chapter, we will review the latest researches of text mining in the domain of geoscience and present results from a few case studies. The research includes three major parts: (1) structuralization of geological literature, (2) information extraction and visualization for geological literature, and (3) geological text mining to assist database construction and knowledge discovery.
Higher-dimensional voronoi diagrams in linear expected time

A general method is presented for determining the mathematical expectation of the combinatorial complexity and other properties of the Voronoi diagram ofn independent and identically distributed points. The method is applied to derive exact asymptotic bounds on the expected number of vertices of the Voronoi diagram of points chosen from the uniform distribution on the interior of ad-dimensional ball; it is shown that in this case, the complexity of the diagram is ∵(n) for fixedd. An algorithm for constructing the Voronoid diagram is presented and analyzed. The algorithm is shown to require only ∵(n) time on average for random points from ad-ball assuming a real-RAM model of computation with a constant-time floor function. This algorithm is asymptotically faster than any previously known and optimal in the average-case sense.
Minority stressors, rumination, and psychological distress in monozygotic twins discordant for sexual minority status

Abstract Background Lesbian, gay, and bisexual (LGB) individuals report higher levels of depression and anxiety than heterosexual people. Genetic factors may be a ‘common cause’ of sexual minority status and psychological distress. Alternatively, these may be correlated because of non-genetic environmental factors (e.g. minority stressors). This study investigated minority stressors and distress in monozygotic twins discordant for sexual minority status. This design provides a test of the role of non-shared environmental factors while minimizing differences due to genetics. Methods Thirty-eight twin pairs in which one was heterosexual and the other was LGB completed a survey. Differences between twin pairs in minority stressors, rumination, psychological distress, and gender non-conformity were examined. Associations between these variables were also tested. Results Although there were no significant group differences for distress, LGB twins had higher rumination, a vulnerability factor for distress, than heterosexual co-twins. LGB twins also had higher scores than heterosexual co-twins on expectations of rejection, active concealment, self-stigma, prejudice events, childhood gender non-conformity, and lower scores on sexual orientation disclosure. Differences between twin pairs in rumination were positively associated with differences in acceptance concerns and self-stigma. Finally, self-stigma was positively associated with rumination in the full sample of heterosexual co-twins and microaggressions were positively associated with rumination when looking at exclusively heterosexual co-twins. Conclusions These results support environmental factors as a causal explanation for disparities in rumination between LGB and heterosexual individuals. These factors likely include minority stressors. Rumination may also be associated with minority stressors in heterosexual MZ co-twins of LGB individuals.
1D to 3D dimensional crossover in the superconducting transition of the quasi-one-dimensional carbide superconductor Sc3CoC4

The transition metal carbide superconductor Sc3CoC4 may represent a new benchmark system of quasi-one-dimensional (quasi-1D) superconducting behavior. We investigate the superconducting transition of a high-quality single crystalline sample by electrical transport experiments. Our data show that the superconductor goes through a complex dimensional crossover below the onset Tc of 4.5 K. First, a quasi-1D fluctuating superconducting state with finite resistance forms in the [CoC4]∞ ribbons which are embedded in a Sc matrix in this material. At lower temperature, the transversal Josephson or proximity coupling of neighboring ribbons establishes a 3D bulk superconducting state. This dimensional crossover is very similar to Tl2Mo6Se6, which for a long time has been regarded as the most appropriate model system of a quasi-1D superconductor. Sc3CoC4 appears to be even more in the 1D limit than Tl2Mo6Se6.
IL-3 and Oncogenic Abl Regulate the Myeloblast Transcriptome by Altering mRNA Stability

The growth factor interleukin-3 (IL-3) promotes the survival and growth of multipotent hematopoietic progenitors and stimulates myelopoiesis. It has also been reported to oppose terminal granulopoiesis and to support leukemic cell growth through autocrine or paracrine mechanisms. The degree to which IL-3 acts at the posttranscriptional level is largely unknown. We have conducted global mRNA decay profiling and bioinformatic analyses in 32Dcl3 myeloblasts indicating that IL-3 caused immediate early stabilization of hundreds of transcripts in pathways relevant to myeloblast function. Stabilized transcripts were enriched for AU-Response elements (AREs), and an ARE-containing domain from the interleukin-6 (IL-6) 3′-UTR rendered a heterologous gene responsive to IL-3-mediated transcript stabilization. Many IL-3-stabilized transcripts had been associated with leukemic transformation. Deregulated Abl kinase shared with IL-3 the ability to delay turnover of transcripts involved in proliferation or differentiation blockade, relying, in part, on signaling through the Mek/Erk pathway. These findings support a model of IL-3 action through mRNA stability control and suggest that aberrant stabilization of an mRNA network linked to IL-3 contributes to leukemic cell growth.