Miracle-dz/UniFAR-FTUs huggingface dataset:
Playing Games with Deep Reinforcement Learning

Recently, Google Deepmind showcased how Deep learning can be used in conjunction with existing Reinforcement Learning (RL) techniques to play Atari games[10], beat a world-class player [13] in the game of Go and solve complicated riddles [3]. Deep learning has been shown to be successful in extracting useful, nonlinear features from high-dimensional media such as images, text, video and audio [11]. For control tasks like playing games, researchers have traditionally used handcrafted-features which require a lot of human effort. Convolutional neural networks (CNN) can be used to extract useful visual features from the highdimensional input, such as a video game screen, to learn near-optimal value function in such control tasks. We chose the Arcade Learning environment as our testbed to examine how deep learning can be applied to a reinforcement learning setting and analyze performance of various modern algorithms. The learning is performed end-to-end with no game knowledge included in the architecture or during training. We also show how the architecture of the deep network used, can be modified to achieve superior performances and compare performances on the task of playing a complicated game Seaquest.
Physical layer security in two-path successive relaying

This paper proposes a bandwidth-efficient transmission protocol with one source, one destination and two assisting half-duplex relays. The two relays operate alternately in a time-division-duplex mode to forward messages from source to destination in the presence of an eavesdropper. Therefore, the source transmits new information continuously and the bandwidth efficiency of ideal full-duplex relay network can be achieved. The two relays provide higher diversity gain compared to the existing schemes assisted by one relay. By considering the achievable secrecy rate as the minimum between the secrecy rate of the S-R and R-D links, the achievable secrecy capacity can be improved. We investigate the performance of the protocol in terms of ergodic secrecy capacity and secrecy outage probability and compared to the existing half-duplex relaying, full-duplex relaying and full-duplex jamming schemes. The proposed protocol achieves the highest ergodic secrecy capacity and the lowest probability of secrecy outage compared to the existing schemes.
Is there a place for external mesh wrapping of abdominal aortic aneurysms in the modern endovascular era?

Introduction due to unacceptably high operative risk. Comorbidities and factors that influenced our decision to consider External mesh wrapping is an old idea practised long mesh-wrapping are shown in Table 1. All operations were performed by a single surgeon using a transverse before the first successful abdominal aortic aneurysm (AAA) repair. In recent years, with the advent of abdominal incision. The aorta was exposed proximally, distally, and on both sides, but no attempt was made endovascular surgery, this technique is mainly of historical interest. However, not all aneurysms are suitto mobilise the posterior aspect of the aneurysm from its attachment to the anterior longitudinal ligament of able for endovascular repair. Occasionally, vascular surgeons are faced with the dilemma of a patient the spine. The lumbar and inferior mesenteric arteries were left undisturbed. A sheath of Marlex mesh was deemed unfit for open repair and an aneurysm unsuitable for endovascular repair. The option they have used to wrap the anterior and lateral aspects of the aneurysm and stitched down on the sides of the anthen is to opt for no operation at all, or consider less invasive alternatives. In this report we present a single terior longitudinal ligament with interrupted sutures. The peritoneum was then closed over the top of the surgeon’s experience with external mesh wrapping of AAAs. mesh. Postoperatively, patients were followed up in the outpatients department.
Electron-Ion Recombination of Fe V

Ionization balance in the low-ionization stages of iron is important in a variety of astrophysical plasmas. Accurate recombination rates are needed but are difficult to compute in a detailed quantum mechanical treatment. The main difficulty lies in the complexity of strong electron-electron correlation arising due to the open 3d shell. We present the total electron-ion recombination rate coefficients for the process, e+Fe VI → Fe V, obtained in an ab initio manner. Large-scale computations are carried out in the close coupling (CC) approximation using the R-matrix method employing a unified treatment that considers the infinite number of states of the recombined ion and incorporates both the radiative recombiantion (RR) and the dielectronic recombination (DR) processes in a self-consistent manner. It involves calculations of detailed photoionization cross sections, σPI, with autoionizing resonances of a large number of bound states with n≤nmax, such as 1054 bound states for the present case of Fe V. The number also equals the total number of state-specific recombination rates obtained for the ion. The high-n states are treated through the DR theory by Bell & Seaton. The same wavefunction expansion is employed in all photoionization/recombination calculations, thereby ensuring self-consistency. Rates are presented at a wide range of temperature for all practical applications. Present rates for total recombination differ considerably from currently used values obtained using simpler approximations. Application of the new recombination rate coefficients and photoionization cross sections for the ionization structure of iron in planetary nebulae show that under typical conditions the relative fractions of Fe V and Fe VI change by nearly a factor of 2.
Underemployment and relative deprivation among re‐employed executives

Using a sample of 517 executives who lost their jobs as a result of downsizing, this study examined underemployment among managers in replacement jobs taken after their layoffs. Laid-off executives who were re-employed in jobs which paid less, were at lower levels of organizational hierarchies and which did not fully utilize their skills had consistently lower job attitudes. In addition, the results suggest that relative deprivation is an important mediator in explaining how underemployment leads to poorer psychological well-being in those replacement jobs. The article concludes with directions for future research on underemployment and relative deprivation in the aftermath of layoffs.
Macrophage-restricted and Interferon γ-inducible Expression of the Allograft Inflammatory Factor-1 Gene Requires Pu.1*

Expression of allograft inflammatory factor-1 (Aif-1), a 17-kDa protein bearing an EF-hand Ca2+ binding motif, increases markedly in monocytes and macrophages participating in allo- and autoimmune reactions, including the perivascular inflammation in transplanted hearts, microglial infiltrates in experimental autoimmune neuritis, and the inflamed pancreas of prediabetic BB rats. To investigate the mechanism of this regulation, we isolated the mouse aif-1 gene and determined its genomic organization. The gene has six exons distributed over 1.6 kilobases, an interferon γ-inducible DNase I-hypersensitive site near −900, and flanking sequences on either side predicted to associate with nuclear matrix. Reporter gene analyses identified sequences between −902 and −789, including consensus Ets and interferon regulatory factor elements, required for macrophage-specific and interferon γ-inducible transcriptional activity. Pu.1 bound to the Ets site in electromobility shift assay and forced expression of Pu.1 activated the aif-1 promoter in 3T3 fibroblasts, in which it is normally inactive. However, the transcriptional activity of a concatamer of the Ets site alone did not increase with interferon γ treatment. Cooperation between Pu.1 and proteins binding to the interferon regulatory factor element appears to be necessary for both macrophage-specific and interferon γ-inducible expression of theaif-1 gene.
Technological analysis via dielectric spectroscopy of materials containing recycled PET and wood derivates

Focused on broadband dielectric analysis of recycled PET base / wood derivates composites, the article tries to emphasize the influence of mass additives and modifying reagents content (herein wood powder, natron-lignin and maleic anhydride derivates), and, based on specific dielectric parameters, to account for the optimum materials structure and technology.
Techniques for designing a classifier for multimedia indexing

This paper addresses the issues involved in designing a classifier for multimedia indexing, a representative of domain of tasks involving high dimensionality of feature space and large dissimilarity between features in range and variation, and requiring a strong inference mechanisms. We consider decision trees, Bayesian network, neural network and support vector approaches. The Modified Bayesian Network (MBN), as designed by us offers significant advantages over other approaches. The application of Bayesian network has generally been restricted to domains having discrete variable values, or to the domain with continuos variable values which approximate to Gaussian distribution. However, MBN can form sound representation of non-Gaussian Multimodal continuous distribution, as is the case with feature space in multimedia indexing. This can be accomplished by intelligent partitioning and data clique association. The structure of MBN and its functionality on real video is also presented in the paper.
Early Cannulation Graft: Acuseal

Aim To review the published literature on the early cannulation graft, Acuseal. Methods 235 reported cases have been published and reviewed. These cases are both prospective and retrospective, from either multicenter or single centers. Patency rates and complication rates were reviewed. Economic value of early cannulation grafts were also analyzed. Results Over 135 patients were cannulated within 2.5 days after implantation. No increase in complications were noted and similar primary and secondary patency rates were observed compared to the literature. Economic evaluation both in the UK and US demonstrate benefit of this graft when compared to catheters, fistulas and other grafts. Conclusion Early stick grafts demonstrate similar patency and complication rates when compared to published literature of standard grafts. Economic benefit is also noted using this graft.
Human anti-V2 monoclonal antibody that neutralizes primary but not laboratory isolates of human immunodeficiency virus type 1

A human immunoglobulin G1 lambda monoclonal antibody (MAb), 697-D, was developed that recognizes the V2 region of human immunodeficiency virus type 1 (HIV-1) gp120. Substitutions at amino acid positions 176/177, 179/180, 183/184, and 192 to 194 in the V2 loop of gp120 each completely abolished the binding capacity of 697-D in an enzyme-linked immunosorbent assay format. Competition analysis with three different neutralizing murine anti-V2 MAbs confirmed the specificity of 697-D. The 697-D epitope is primarily conformation dependent, although there was weak reactivity of the MAb with a V2 peptide spanning residues 161 to 180. Treatment of recombinant gp120 HIVIIIB with sodium metaperiodate, which oxidizes carbohydrates, abolished the binding of the MAb, showing the dependence of the epitope on intact carbohydrates. The broad reactivity of 697-D was displayed by its binding to the gp120 molecules from four of four laboratory isolates and five of five primary isolates. The MAb 697-D neutralized three out of four primary isolates but failed to neutralize any of four laboratory strains of HIV-1. 697-D and a human anti-V3 MAb, 447-52-D, displayed similar potency in neutralizing primary isolates, indicating that the V2 region of gp120, like the V3 region and the CD4-binding domain, can induce potent neutralizing antibodies against HIV-1 in humans.
The 3′ to 5′ exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication.

In Saccharomyces cerevisiae, DNA polymerase delta (POLIII), the product of the CDC2 (POL3) gene, possesses, in its N‐terminal half, the well conserved 3‐domain 3′ to 5′ exonuclease site. Strains selectively mutagenized in this site display a mutator phenotype detected as a drastically increased spontaneous forward mutation rate to canavanine resistance or as an elevated reversion rate to lysine prototrophy. Assays on a partially purified extract of the mutant giving the largest mutator effect indicate that the 3′ to 5′ exonuclease activity is reduced below the detection limit whereas the DNA polymerizing activity has wild‐type level. Therefore, our results provide experimental support for the hypothesis that the exonucleolytic proofreading activity associated with DNA polymerase delta resides on the DNA polymerase delta subunit and enhances the fidelity of DNA replication in yeast.
The Last Pharaohs: Egypt Under the Ptolemies, 305-30 BC

List of Illustrations ix Preface xi Abbreviations xv INTRODUCTION 1 CHAPTER 1: Egypt in the First Millennium BC 19 CHAPTER 2: The Historical Understanding of the Ptolemaic State 29 CHAPTER 3: Moving beyond Despotism, Economic Planning, and State Banditry 55 Ptolemaic Egypt as a Premodern State CHAPTER 4: Shaping a New State 73 The Political Economy of the Ptolemies CHAPTER 5: Creating a New Economic Order 117 Economic Life and Economic Policy under the Ptolemies CHAPTER 6: Order and Law 165 Shaping the Law in a New State CHAPTER 7: Conclusions 202 APPENDIX 207 The Trial Record of the Property Dispute Held at the Temple of Wepwawet in Asyut, Upper Egypt, 170 BC before the Local Laokritai-judges Bibliography 217 Index 259 Index of Sources 263
Improving drug delivery to primary and metastatic brain tumors: Strategies to overcome the blood–brain barrier

Brain tumor diagnosis has an extremely poor prognosis, due in part to the blood–brain barrier (BBB) that prevents both early diagnosis and effective drug delivery. The infiltrative nature of primary brain tumors and the presence of micro‐metastases lead to tumor cells that reside behind an intact BBB. Recent genomic technologies have identified many genetic mutations present in glioma and other central nervous system (CNS) tumors, and this information has been instrumental in guiding the development of molecularly targeted therapies. However, the majority of these agents are unable to penetrate an intact BBB, leading to one mechanism by which the invasive brain tumor cells effectively escape treatment. The diagnosis and treatment of a brain tumor remains a serious challenge and new therapeutic agents that either penetrate the BBB or disrupt mechanisms that limit brain penetration, such as endothelial efflux transporters or tight junctions, are required in order to improve patient outcomes in this devastating disease.
An Improved PSO Algorithm and Its Application to UWB Antenna Design

An improved particle swarm optimization (PSO) algorithm with a neighborhood-redispatch (NR) technique is presented to design an ultrawideband (UWB) antenna in this letter. Based on the conventional version of PSO algorithm, some new parameters are introduced in the NR-PSO algorithm to improve optimization performance. In order to illustrate the effectiveness of the algorithm in representative topology problems, several benchmark functions are used to test the performance of the improved PSO algorithm. The results show that it is better than the conventional PSO algorithm for multimodal and unimodal functions. Combined with the HFSS solver, one UWB antenna with a respective notched band is designed by using the proposed NR-PSO algorithm. It not only covers the UWB band (3.1-10.6 GHz) and Bluetooth passband (2.40-2.484 GHz), but also realizes a stopband (5.15-5.825 GHz) to avoid potential interferences.
High-speed bend test method and failure prediction for drop impact reliability

The objective of this study is to obtain experimental failure models governing solder joint failure during drop impact testing of board assemblies. A high-speed bend test was developed to perform displacement-controlled bend test of board assemblies at the high flexing frequencies of drop impact. These test frequencies and amplitudes are not achievable by conventional universal testers. Experimental data was obtained for various PCB strain amplitudes, flexural frequencies solder alloys and pad finishes. Results from the high-speed bend tests are used to construct constant amplitude power law fatigue curves. Solder joint reliability found to be dependent on the test frequency, and therefore strain rate. The experimental failure data from these high-speed bend tests are a required basis for a drop impact failure criterion which can take into account frequency and amplitude effects and which is general enough to be applied to product level testing
Maximizing the use of a web‐based teaching skills curriculum for community‐based volunteer faculty

Background: The University of Kansas School of Medicine in Wichita created an Internet‐based faculty development curriculum for community‐based faculty. Because relatively few physicians use Internet‐based continuing medical education (CME), the most cost‐effective methods of encouraging use need to be identified. Method: Five interventions intended to increase use of the curriculum were assessed. The number of times the CME curriculum Webpages were accessed was correlated with the interventions. Results: Demonstrating the Website to faculty at a semiannual meeting elicited the most Website “hits. ” Electronic mail and flyers also appeared to be effective in stimulating interest in the Website. Only four community‐based faculty applied for CME credit for completing the curricular modules. Findings: Multiple modalities should be used in advertising and stimulating interest in an Internet‐based faculty development curriculum. Demonstrating the Website to faculty at a meeting appeared to achieve the greatest return. Offering CME credit was not helpful in stimulating interest.
DNA Millichips as a Low-Cost Platform for Gene Expression Analysis1[W][OA]

Our goal was to create a DNA chip that is as easy, convenient, and inexpensive as an agarose gel. For a first-generation solution, we describe a low-cost, easy-to-use de novo synthesis oligonucleotide microarray technology that draws on the inherent flexibility of the maskless array synthesizer for in situ synthesis of thousands of photolithographically produced oligonucleotides covalently attached to a microscope slide. The method involves physically subdividing the slide into 1 × 1 mm millichips that are hybridized to fluorescent RNA or DNA of biological origin, in a microfuge tube at an ordinary laboratory benchtop, rather than in dedicated hybridization chambers. Fluorescence intensity is then measured with a standard microscope rather than sophisticated DNA chip scanners. For proof of principle, we measured changes in the transcriptome of Arabidopsis (Arabidopsis thaliana) plants induced by growth in the presence of three major environmental abiotic stresses (temperature, light, and water status), in all possible combinations. Validation by comparison with quantitative reverse transcription PCR showed a high correlation coefficient and analysis of variance indicated a high technical reproducibility. These experiments demonstrate that low-cost DNA millichips can be made and reliably used at the benchtop in a normal laboratory setting, without assistance of core facilities containing costly specialized instrumentation.
Etude des phénomènes de biotransformation des hydrocarbures aromatiques polycycliques (HAP) par les organismes aquatiques (poissons) : relation exposition - génotoxicité

Afin d’etudier la sante d’un ecosysteme marin et le potentiel toxique d’une contamination telle que celle liee a la presence d’hydrocarbures aromatiques polycycliques (HAP), il est necessaire, outre de connaitre les niveaux de contamination du milieu, de pouvoir acceder a la fraction toxique a laquelle les organismes aquatiques ont ete exposes et de connaitre les effets toxiques des contaminants incrimines. L’exposition et la contamination des organismes aquatiques aux HAP ont generalement ete evaluees par le dosage des HAP bioaccumules dans les tissus. Or, cette approche est critiquable si l'on tient compte des capacites de biotransformation des organismes, notamment des vertebres, et des proprietes toxiques des produits de transformation formes. Dans ce contexte, l’objectif de cette these est d’etudier les phenomenes de bioccumulation et de biotransformation des HAP chez les organismes marins via l’etude des metabolites de HAP. Un effort de validation de biomarqueurs pertinents pour evaluer la genotoxicite des HAP en lien avec la contamination chimique des tissus et la production de metabolites est necessaire. Des methodes de dosage des metabolites de HAP dans les matrices biologiques ont tout d’abord ete mises au point. Ces outils analytiques sensibles, innovants et performants ont ensuite ete appliques lors d’expositions de poissons a des HAP via differentes voies de contamination en milieu controle. Ils ont permis une meilleure connaissance des phenomenes de biotransformation des HAP. Enfin, des etudes de terrain ont ete realisees, notamment dans le cadre de l’etude de la contamination de la Baie de Seine, montrant l’applicabilite du dosage des metabolites de HAP dans l’evaluation de l’exposition des organismes aux HAP en milieu naturel. Dans le cadre d’une approche integree chimie/biologie, ces travaux ont permis d’apporter une contribution dans le transfert methodologique des biomarqueurs de genotoxicite des HAP pour des applications en surveillance de l’Atlantique Nord et notamment dans la Manche.
Modeling and simulation of loader working device based on SimMechanics

In this paper, with Pro/E and SimMechanics as tools, by the method of building solid models of loader working device in Pro/E, and then transforming CAD models into SimMechanics model, the simulation animation and bucket tooth point locus diagram under the given driver of the working device can be got. The results show that the simulation method is good at analyzing a variety of movement of mechanical system, and provides a convenient way for practical engineering application by taking advantage of convenient modeling, powerful simulation and automatic model analysis.
Diagnostic prediction of multi-class cancer using SVM and nearest neighbor classifier

Precise diagnosis of four heterogeneous childhood cancers, namely, neuroblastoma, non-Hodgkin lymphoma, rhabdomyosarcoma and Ewing sarcoma is crucial because they present a similar histology of small round blue cell tumors (SRBCTs) and frequently leads to misdiagnosis. However, due to small number of samples compared to very large number of genes in microarray gene expression data, it is hard to identify a small subset of relevant genes that can classify these four subgroups of childhood cancers with high accuracy. Therefore, in this paper, we have utilized t-test to rank all the genes according to their importance. Support vector machine (SVM) with different kernels and a simple 1-nearest neighbor (1-NN) classifier have been used to perform the classification task. Results demonstrate that the method could find very few numbers of genes for the diagnostic prediction of cancer subgroups.