Miracle-dz/UniFAR-FTUs huggingface dataset:
Computation of Losses in HTS Under the Action of Varying Magnetic Fields and Currents

Numerical modeling of superconductors is widely recognized as a powerful tool for interpreting experimental results, understanding physical mechanisms, and predicting the performance of high-temperature-superconductor (HTS) tapes, wires, and devices. This is particularly true for ac loss calculation since a sufficiently low ac loss value is imperative to make these materials attractive for commercialization. In recent years, a large variety of numerical models, which are based on different techniques and implementations, has been proposed by researchers around the world, with the purpose of being able to estimate ac losses in HTSs quickly and accurately. This paper presents a literature review of the methods for computing ac losses in HTS tapes, wires, and devices. Technical superconductors have a relatively complex geometry (filaments, which might be twisted or transposed, or layers) and consist of different materials. As a result, different loss contributions exist. In this paper, we describe the ways of computing such loss contributions, which include hysteresis losses, eddy-current losses, coupling losses, and losses in ferromagnetic materials. We also provide an estimation of the losses occurring in a variety of power applications.
An acetylase with relaxed specificity catalyses protein N‐terminal acetylation in Sulfolobus solfataricus

N‐terminal protein acetylation is common in eukaryotes and halophilic archaea, but very rare in bacteria. We demonstrate that some of the most abundant proteins present in the crenarchaeote Sulfolobus solfataricus, including subunits of the thermosome, proteosome and ribosome, are acetylated at the N‐terminus. Modification was observed at the N‐terminal residues serine, alanine, threonine and methionine‐glutamate. A conserved archaeal protein, ssArd1, was cloned and expressed in Escherichia coli, and shown to acetylate the same N‐terminal sequences in vitro. The specific activity of ssArd1 is sensitive to protein structure in addition to sequence context. The crenarchaeota and euryarchaeota apparently differ in respect of the frequency of acetylation of Met–Glu termini, which appears much more common in S. solfataricus. This sequence is acetylated by the related Nat3 acetylase in eukarya. ssArd1 thus has a relaxed sequence specificity compared with the eukaryotic N‐acetyl transferases, and may represent an ancestral form of the enzyme. This represents another example where archaeal molecular biology resembles that in eukaryotes rather than bacteria.
Sequential changes in susceptibility to Treponema pallidum of rabbits previously infected with Treponema paraluis-cuniculi

Rabbits immunised with virulent Treponema paraluis-cuniculi were challenged intradermally with graded doses of Treponema pallidum at three, five, seven, 12, and 30 months to ascertain the level of protection to T pallidum at various intervals after immunisation. Rabbits challenged at three months after immunisation showed no protection against T pallidum and developed syphilitic lesions significantly faster than the control rabbits, which suggests that the former rabbits were immunosuppressed. Some protection was evident at five and seven months after immunisation, as fewer inoculation sites developed syphilitic lesions with challenges of 103, 102, and 10 T pallidum and lesions developed significantly slower with 106 challenge. Two rabbits showed significant protection at 12 months after immunisation but a third, presumably still immunosuppressed, developed lesions significantly faster than the control rabbits after challenge. At 30 months after immunisation one rabbit was completely protected and developed no lesions after challenge; the other rabbit showed only partial protection against challenge with 104, 103, and 102 but complete protection against challenge with 10 T pallidum. T paraluis-cuniculi appeared to induce a state of immunosuppression by three months after infection; in one rabbit this may have been 12 months. In most immunised rabbits, however, limited cross-protection to low challenge doses of T pallidum developed by five months and was also detectable at seven and 12 months. Only one rabbit was completely resistant to challenge with 104T pallidum after 30 months and another was only partly immune. Thus, T paraluis-cuniculi infection does not produce a rapid pronounced cross-immunity to T pallidum in rabbits, which may thus limit its usefulness as a vaccine against syphilis.
Botanical features for identification of Gymnosporia arenicola dried leaf

Gymnosporia arenicola Jordaan (Celastraceae) is a shrub or small tree, which naturally occurs in coastal sand dunes of Southern Mozambique and South Africa. Its dried leaf is often used in traditional medicine for the treatment of infectious and inflammatory diseases. Hereby, we present results of studies carried out according to the pharmacopoeia standards for the identification of herbal drugs, in the whole, fragmented, and powdered plant material. These results were complemented with scanning electron microscopy and histochemical techniques. The leaf microscopic analysis revealed a typical dorsiventral mesophyll with a corresponding spongy parenchyma–palisade parenchyma ratio of 0.60, anomocytic and paracytic stomata, papillate cells with a diameter of 4.00 ± 0.40 µm, multicellular uniseriate nonglandular trichomes with a length of 27.00 ± 4.10 µm and cristalliferous idioblasts containing calcium oxalate cluster crystals with a diameter of 23.04 ± 5.84 µm. The present findings demonstrate that the G. arenicola leaf has both nonglandular trichomes and hypoderm, features not previously described in the corresponding botanical section (Gymnosporia sect. Buxifoliae Jordaan). The establishment of these new botanical markers for the identification of G. arenicola leaf is essential for quality, safety and efficacy reasons. Microsc. Res. Tech. 78:1001–1009, 2015. © 2015 Wiley Periodicals, Inc.
Three acidic residues are at the active site of a β‐propeller architecture in glycoside hydrolase families 32, 43, 62, and 68

Multiple‐sequence alignment of glycoside hydrolase (GH) families 32, 43, 62, and 68 revealed three conserved blocks, each containing an acidic residue at an equivalent position in all the enzymes. A detailed analysis of the site‐directed mutations so far performed on invertases (GH32), arabinanases (GH43), and bacterial fructosyltransferases (GH68) indicated a direct implication of the conserved residues Asp/Glu (block I), Asp (block II), and Glu (block III) in substrate binding and hydrolysis. These residues are close in space in the 5‐bladed β‐propeller fold determined for Cellvibrio japonicus α‐L‐arabinanase Arb43A [Nurizzo et al., Nat Struct Biol 2002;9:665–668] and Bacillus subtilis endo‐1,5‐α‐L‐arabinanase. A sequence–structure compatibility search using 3D‐PSSM, mGenTHREADER, INBGU, and SAM‐T02 programs predicted indistinctly the 5‐bladed β‐propeller fold of Arb43A and the 6‐bladed β‐propeller fold of sialidase/neuraminidase (GH33, GH34, and GH83) as the most reliable topologies for GH families 32, 62, and 68. We conclude that the identified acidic residues are located at the active site of a β‐propeller architecture in GH32, GH43, GH62, and GH68, operating with a canonical reaction mechanism of either inversion (GH43 and likely GH62) or retention (GH32 and GH68) of the anomeric configuration. Also, we propose that the β‐propeller architecture accommodates distinct binding sites for the acceptor saccharide in glycosyl transfer reaction. Proteins 2004. © 2003 Wiley‐Liss, Inc.
1‐methyl‐4‐phenylpyridinium neurotoxicity is attenuated by adenoviral gene transfer of human Cu/Zn superoxide dismutase

Oxidative stress has been suggested to be an important mediator of dopaminergic cell death in Parkinson's disease (PD). We investigated the neuroprotective potential of Cu/Zn superoxide dismutase (SOD1) overexpression in the rat substantia nigra (SN) following adenovirus‐mediated gene transfer. Human dopaminergic SK‐N‐SH cells were transduced with adenoviral vectors expressing either human SOD1 (Ad‐SOD1) or β‐galactosidase (Ad‐βgal) before exposure to 1 mM of the 1‐methyl‐4‐phenylpyridinium ion (MPP+). A strong neuroprotective effect of SOD1 gene transfer was observed in the SK‐N‐SH cells exposed to MPP+ compared with controls. Adult rats were then given unilateral injections of either Ad‐SOD1 or Ad‐βgal into the striatum, and MPP+ was administered 8 days later at the same location. Strong transgene expression was detected in the SN dopaminergic neurons, a consequence of retrograde axonal transport of the adenoviral particles. The amphetamine‐induced rotational behavior of the rats was markedly lower in Ad‐SOD1‐injected rats than in control animals. Also, behavioral recovery significantly correlated with the number of tyrosine hydrolase‐expressing neurons in the SN of the treated rats. These results are consistent with oxidative stress contributing to the MPP+‐induced neurodegenerative process. They also indicate that SOD1 gene transfer into the nigrostriatal system may be a potential neuroprotective strategy for treating PD. © 2005 Wiley‐Liss, Inc.
Assessing business model relevance for business leaders in the construction industry

This paper studies the business model (BM) relevance for business leaders in the construction industry. Specifically, we address the question of the comprehension and utility of the generation, remuneration, participation (GRP) model, a BM representation, for leaders within an established sector. Using an action research methodology, our findings empirically prove that the BM can be taken out of its original context of start-ups, and used within existing organisations. Our results also suggest that in traditional small-sized companies, where strategic tools are rarely mobilised, the BM might be appropriate for leaders to address the question of business growth. Interaction between leaders and researchers also contributed to the advancement of the GRP model and the homogenisation of its visual representation.
Battery Health Prognosis for Electric Vehicles Using Sample Entropy and Sparse Bayesian Predictive Modeling

Battery health monitoring and management is of extreme importance for the performance and cost of electric vehicles. This paper is concerned with machine-learning-enabled battery state-of-health (SOH) indication and prognosis. The sample entropy of short voltage sequence is used as an effective signature of capacity loss. Advanced sparse Bayesian predictive modeling (SBPM) methodology is employed to capture the underlying correspondence between the capacity loss and sample entropy. The SBPM-based SOH monitor is compared with a polynomial model developed in our prior work. The proposed approach allows for an analytical integration of temperature effects such that an explicitly temperature-perspective SOH estimator is established, whose performance and complexity is contrasted to the support vector machine (SVM) scheme. The forecast of remaining useful life is also performed via a combination of SBPM and bootstrap sampling concepts. Large amounts of experimental data from multiple lithium-ion battery cells at three different temperatures are deployed for model construction, verification, and comparison. Such a multi-cell setting is more useful and valuable than only considering a single cell (a common scenario). This is the first known application of combined sample entropy and SBPM to battery health prognosis.
Tutorial on LTE/LTE-A Cellular Network Dimensioning Using Iterative Statistical Analysis

LTE is the fastest growing cellular technology and is expected to increase its footprint in the coming years, as well as progress toward LTE-A. The race among operators to deliver the expected quality of experience to their users is tight and demands sophisticated skills in network planning. Radio network dimensioning (RND) is an essential step in the process of network planning and has been used as a fast, but indicative, approximation of radio site count. RND is a prerequisite to the lengthy process of thorough planning. Moreover, results from RND are used by players in the industry to estimate preplanning costs of deploying and running a network; thus, RND is, as well, a key tool in cellular business modelling. In this work, we present a tutorial on radio network dimensioning, focused on LTE/LTE-A, using an iterative approach to find a balanced design that mediates among the three design requirements: coverage, capacity, and quality. This approach uses a statistical link budget analysis methodology, which jointly accounts for small and large scale fading in the channel, as well as loading due to traffic demand, in the interference calculation. A complete RND manual is thus presented, which is of key importance to operators deploying or upgrading LTE/LTE-A networks for two reasons. It is purely analytical, hence it enables fast results, a prime factor in the race undertaken. Moreover, it captures essential variables affecting network dimensions and manages conflicting targets to ensure user quality of experience, another major criterion in the competition. The described approach is compared to the traditional RND using a commercial LTE network planning tool. The outcome further dismisses the traditional RND for LTE due to unjustified increase in number of radio sites and related cost, and motivates further research in developing more effective and novel RND procedures.
Mental Health Symptoms Among Student Service Members/Veterans and Civilian College Students

Abstract Objective: The aim of this study was to investigate if and to what extent student service members/veterans differ from civilian college students in the prevalence of self-reported symptoms of poor mental health. Participants: The Fall 2011 implementation of the American College Health Association–National College Health Assessment included 27,774 respondents from 44 colleges and universities. Methods: Participants were matched using propensity scores, and the prevalence of symptoms was compared using logistic regression and zero-inflated negative binomial regression models. Results: The odds of feeling overwhelmed in the last 12 months were significantly lower among student service members/veterans with a history of hazardous duty (odd ratio [OR] = 0.46, adjusted p value <.05) compared with civilian students. Military service, with and without hazardous duty deployment, was not a significant predictor of the total number of symptoms of poor mental health. Conclusions: Current student service members/veterans may not be disproportionately affected by poor psychological functioning.
Public Policy, Innovation and Economic Growth: An Economic and Technological Perspective on Pakistan’s Telecom Industry

At a time of rapid technological advancements in every field, Pakistan must develop a comprehensive strategy for harnessing science and technology to promote economic growth on a sustained basis. In recent decades, successful economies have moved away from factor accumulation models of economic growth to productivity led growth that is underpinned by technological advancements and innovations. Using the endogenous growth theory as a framework of analysis, the paper will provide a macroeconomic perspective on the importance of technology and innovation for sustainable economic growth. We argue that public policy must be geared to generate robust growth by encouraging investment in research and development (R&D) and human capital. The paper will conceptualize the role of technology in the process of economic growth and identify policy areas that can be instrumental in promoting technological modernization and innovations.
An Analysis on the Factors Affecting the Social Security

The transition from strong centralized economy to the free market economy was one of major movements which include radical changes in the politics, economics, administration and structural field. So, it was necessary to conduct a series of increasing reforms. In this context, the pension (retirement) reform is a very important one. Many insurance schemes directed by the state, based on 'pay-as-you-go' principle, such as the current Albanian social insurance system. This scheme does not promote the interests of employees being included in the current social insurance scheme. The best practices prove the fact that mandatory social insurance should not be the only option. So, parallel with mandatory social insurance is better to have the private insurance pension scheme, as well. The paper focuses on some issues of social insurance.
Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells.

WNT, Notch, FGF, and Hedgehog signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. Association of Notch ligands with Notch receptors on neighboring cells leads to cleavage of Notch receptors by metalloprotease and gamma-secretase to induce nuclear translocation of Notch intracellular domain (NICD). Nuclear complex, consisting of CSL (RBPSUH), NICD, Mastermind (MAML), p300 and histone acetyltransferase (HAT), then induces transcriptional activation of Notch target genes, such as HES1, HES5, HES7, HEY1, HEY2 and HEYL. Here, we searched for TCF/LEF-binding site within the promoter region of Notch ligand genes, including DLL1, DLL3, DLL4, JAG1 and JAG2. Because TCF/LEF-binding sites were identified within human JAG1 promoter based on bioinformatics and human intelligence, comparative genomics analyses on JAG1 orthologs were further performed. Chimpanzee JAG1 gene, consisting of 26 exons, was identified within NW_120319. 1 genome sequence. XM_525264. 1 and XM_514517. 1 were not the correct coding sequences for chimpanzee JAG1. Chimpanzee JAG1 gene was found to encode a 1218-amino-acid protein showing 99.5% and 96.2% total-amino-acid identity with human JAG1 and mouse Jag1, respectively. Phylogenetic analysis revealed that JAG1 orthologs were more conserved than those of other Notch ligands. JAG1 gene was identified as evolutionarily conserved target of WNT/beta-catenin signaling pathway based on the conservation of double TCF/LEF-binding sites within 5'-promoter region of mammalian JAG1 orthologs. Human JAG1 mRNA was expressed in embryonic stem (ES) cells, neural tissues, lung carcinoid, gastric cancer, pancreatic cancer, colon cancer, and also in squamous cell carcinoma (SCC) of skin, oral cavity, esophagus, head and neck. JAG1 expression on progenitor cells due to canonical WNT signaling activation induces self-renewal of stem cells due to Notch signaling activation. JAG1, functioning as WNT-dependent Notch signaling activator, is the key molecule maintaining the homeostasis of stem and progenitor cells.
Relationships Between Inhalable, Thoracic, and Respirable Aerosols of Metalworking Fluids

The aim of the study described in this companion paper was to assesses relationships among inhalable, thoracic, and respirable aerosol fractions of metalworking fluids. A RespiCon sampler, which simultaneously collects all three fractions, was used at four Ontario plants to collect 37 samples of 120 to 400 min duration. The ratios of the slopes of the lines of a regression model forced through the origin between inhalable and thoracic, inhalable and respirable, and thoracic and respirable were 1.38, 1.51, and 1.13, respectively. These ratios would be useful in assessing metalworking fluid airborne exposure data based on different aerosol fractions and for interpreting occupational exposure standards based on different fractions.
Evaluation of disruption methods for the release of intracellular recombinant protein from Escherichia coli for analytical purposes

The aim of the present study was to find disruption methods that allow fast and reproducible measurement of intracellular recombinant proteins with potential for on‐line application. Production of rhSOD (recombinant human superoxide dismutase) by Escherichia coli was used as a model. Three methods of cell disruption, sonication, osmotic shock and chemical treatment using a non‐ionic surfactant, were critically compared with respect to efficiency and reproducibility of the release of rhSOD. The release of the recombinant protein was monitored by (i) measurement of the protein content in cell‐culture extracts using an SPR (surface plasmon resonance) biosensor, and (ii) assaying the enzyme activity with a colorimetric reagent using a spectrophotometer. Disruption by the non‐ionic surfactant showed the best performance in terms of simplicity, reproducibility and efficiency of sample treatment. The surfactant did not interfere with the rhSOD binding to the antibody immobilized on the SPR chip or with the rhSOD activity assay. When comparing the two detection methods during monitoring of an E. coli cultivation, comparable results were obtained.
Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A

Chromatin remodeling is essential for controlling the expression of genes during development. The histone-modifying enzyme G9a/KMT1C can act both as a coactivator and a corepressor of transcription. Here, we show that the dual function of G9a as a coactivator vs. a corepressor entails its association within two distinct protein complexes, one containing the coactivator Mediator and one containing the corepressor Jarid1a/KDM5A. Functionally, G9a is important in stabilizing the Mediator complex for gene activation, whereas its repressive function entails a coordinate action with the histone H3 lysine 4 (H3K4) demethylase Jarid1a for the maintenance of gene repression. The essential nature of cross-talk between the histone methyltransferase G9a and the demethylase Jarid1a is demonstrated on the embryonic Ey-globin gene, where the concurrent introduction of repressive histone marks (dimethylated H3K9 and dimethylated H3K27) and removal of activating histone mark (trimethylated H3K4) is required for maintenance of gene silencing. Taken together with our previous demonstration of cross-talk between UTX and MLL2 to mediate activation of the adult βmaj-globin gene, these data suggest a model where “active” and “repressive” cross-talk between histone-modifying enzymes coexist on the same multigene locus and play a crucial role in the precise control of developmentally regulated gene expression.
An Analytical Method for Calculating the Bit Error Rate Performance of Rake Reception in UWB Multipath Fading Channels

In this paper, the bit error rate performance of the Rake reception of binary signals over the IEEE 802.15. 3a ultra- wide bandwidth channel model is evaluated. Instead of using Gaussian approximation for the PDF of the total disturbance, a more accurate method is introduced by using the characteristic function of the interference and the additive white Gaussian noise. A formula for the evaluation of the bit error rate performance of ultra-wide bandwidth systems is thus derived, which can be rapidly calculated by using Gaussian Hermite quadrature with excellent accuracy.