Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk factors for dating violence versus cohabiting violence: Results from the third generation of the Cambridge Study in Delinquent Development.

BACKGROUND Dating violence is an important problem. Evidence suggests that women are more likely to perpetrate dating violence. AIMS The present study investigates the prevalence of dating violence compared with cohabiting violence in a community sample of men and women and assesses to what extent child and adolescent explanatory factors predict this behaviour. A secondary aim is to construct a risk score for dating violence based on the strongest risk factors. METHODS The Cambridge Study in Delinquent Development is a prospective longitudinal survey of 411 men (generation 2) born in the 1950s in an inner London area. Most recently, their sons and daughters [generation 3 (G3)] have been interviewed regarding their perpetration of dating and cohabiting violence, utilising the Conflict Tactics Scale. Risk factors were measured in four domains (family, parental, socio-economic and individual). RESULTS A larger proportion of women than men perpetrated at least one act of violence towards their dating partner (36.4 vs 21.7%). There was a similar pattern for cohabiting violence (39.6 vs 21.4%). A number of risk factors were significantly associated with the perpetration of dating violence. For G3 women, these included a convicted father, parental conflict, large family size and poor housing. For G3 men, these included having a young father or mother, separation from the father before age 16, early school leaving, frequent truancy and having a criminal conviction. A risk score for both men and women, based on 10 risk factors, significantly predicted dating violence. CONCLUSION Risk factors from four domains were important in predicting dating violence, but they were different for G3 men and women. It may be important to consider different risk factors and different risk assessments for male compared with female perpetration of dating violence. Early identification and interventions are recommended. Copyright © 2016 John Wiley & Sons, Ltd.
Cloning and Characterization of Mouse Lung-type Acyl-CoA:Lysophosphatidylcholine Acyltransferase 1 (LPCAT1)

Phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), is an important constituent of biological membranes. It is also the major component of serum lipoproteins and pulmonary surfactant. In the remodeling pathway of PC biosynthesis, 1-acyl-sn-glycero-3-phosphocholine (LPC) is converted to PC by acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT, EC 2.3.1.23). Whereas LPCAT activity has been detected in several tissues, the structure and detailed biochemical information on the enzyme have not yet been reported. Here, we present the cloning and characterization of a cDNA for mouse lung-type LPCAT (LPCAT1). The cDNA encodes an enzyme of 60 kDa, with three putative transmembrane domains. When expressed in Chinese hamster ovary cells, mouse LPCAT1 exhibited Ca2+-independent activity with a pH optimum between 7.4 and 10. LPCAT1 demonstrated a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl- or 1-palmitoyl-LPC as acyl donors and acceptors, respectively. Furthermore, the enzyme was predominantly expressed in the lung, in particular in alveolar type II cells. Thus, the enzyme might synthesize phosphatidylcholine in pulmonary surfactant and play a pivotal role in respiratory physiology.
Gyrodactylids (Gyrodactylidae, Monogenea) infecting Oreochromis niloticus niloticus (L.) and O. mossambicus (Peters) (Cichlidae): A pan-global survey

Gyrodactylus infections in intensively-reared populations of Nile tilapia, Oreochromis niloticus niloticus, have been associated world-wide with high mortalities of juvenile fish. In this study, 26 populations of Gyrodactylus parasitising either O. n. niloticus or Mozambique tilapia, Oreochromis mossambicus, were sampled from fourteen countries and compared with type material of Gyrodactylus cichlidarum Paperna, 1968, Gyrodactylus niloticus (syn. of G. cichlidarum) and Gyrodactylus shariffi Cone, Arthur et Bondad-Reantaso, 1995. Representative specimens from each population were bisected, each half being used for morphological and molecular analyses. Principal component analyses (PCA) identified five distinct clusters: (1) a cluster representing G. cichlidarum collected from O. n. niloticus from 13 countries; (2) the G. shariffi paratype; (3) three specimens with pronounced ventral bar processes collected from two populations of Mexican O. n. niloticus (Gyrodactylus sp. 1); (4) four specimens collected from an Ethiopian population nominally identified as O. n. niloticus (Gyrodactylus sp. 2); (5) nine gyrodactylids from South African O. mossambicus (Gyrodactylus sp. 3). Molecular analyses comparing the sequence of the ribosomal transcribed spacer regions (ITS 1 and 2) and the 5.8S gene from the non-hook bearing half of worms representative for each population and for each cluster of parasites, confirmed the presence of G. cichlidarum in most samples analysed. Molecular data also confirmed that the DNA sequence of Gyrodactylus sp. 2 and Gyrodactylus sp. 3 (the morphologically-cryptic group of South African specimens from O. mossambicus) differed from that of G. cichlidarum and therefore represent new species; no sequences were obtained from Gyrodactylus sp. 1. The current study demonstrates that G. cichlidarum is the dominant species infecting O. n. niloticus, being found in 13 of the 15 countries sampled.
Retinal nerve fibre layer polarimetry: histological and clinical comparison

AIMS To compare histological thickness of the retinal nerve fibre layer in the primate with retardation measurements obtained in vivo using the Mark II Nerve Fiber Analyzer (NFA, Laser Diagnostic Technologies, San Diego, USA). METHODS Scanning laser polarimetry was performed on both eyes of a healthy anaesthetised adult primate (Macaca mulatta). The retinal nerve fibre layer thickness was measured in the eye with the best polarimetry image. A nerve fibre layer thickness map was scaled and aligned to a retardation map to permit correlation of retardation and thickness measurements. RESULTS Retinal nerve fibre layer thickness measurements could be satisfactorily aligned with corresponding retardation values at 216 locations. The overall correlation coefficient for nerve fibre layer thickness and retardation wasr = 0.70 (n = 216, p <0.001). Regional comparison showed the best correlation (r = 0.76, n = 45, p <0.001) occurred inferior to the optic disc. Less positive but still highly significant correlations were seen superiorly and temporally (r = 0.52, n = 26, p = 0.007 andr = 0.49, n = 86, p = <0.001 respectively), with the lowest correlation occurring at the nasal aspect of the disc (r = 0.06, n = 67, p = 0.64). CONCLUSIONS In the primate eye, retinal nerve fibre layer thickness shows a positive correlation with retardation measurements obtained with the nerve fibre analyser. However, since the correlation coefficient varied around the optic disc, further evaluation of the device is advised before its routine clinical use.
Estimates of the Duality Gap in Nonconvex Optimization

We associate with every real-valued function a number which measures its lack of convexity. This number is used to estimate the duality gap in optimization problems where the criterion and/or the constraints are nonconvex. It is shown that when the number of variables is very great with respect to the number of constraints, this duality gap is small in relative value. Approximating in this way problems where the criterion and constraints are given as integrals, we show that the duality gap vanishes.
Support Vector Machine for Multifrequency SAR Polarimetric Data Classification

The objective of this paper is twofold: first, to assess the potential of radar data for tropical vegetation cartography and, second, to evaluate the contribution of different polarimetric indicators that can be derived from a fully polarimetric data set. Because of its ability to take numerous and heterogeneous parameters into account, such as the various polarimetric indicators under consideration, a support vector machine (SVM) algorithm is used in the classification step. The contribution of the different polarimetric indicators is estimated through a greedy forward and backward method. Results have been assessed with AIRSAR polarimetric data polarimetric data acquired over a dense tropical environment. The results are compared to those obtained with the standard Wishart approach, for single frequency and multifrequency bands. It is shown that, when radar data do not satisfy the Wishart distribution, the SVM algorithm performs much better than the Wishart approach, when applied to an optimized set of polarimetric indicators.
Stopping of multicharged ions in dense and fully ionized hydrogen.

The enhanced plasma stopping of energetic (MeV/amu) multicharged ions is experimentally confirmed by inserting a fully ionized hydrogen column on a tandem accelerator ion beam line. Relevance to heavy ion driven inertial compression is emphasized. Measured energy losses are quantitatively matched by a theoretical extension of the cold matter stopping formula (Bethe).
Characterization of operating systems behavior in the presence of faulty drivers through software fault emulation

This paper proposes a practical way to evaluate the behavior of commercial-off-the-shelf (COTS) operating systems in the presence of faulty device drivers. The proposed method is based on the emulation of software faults in target device drivers and the observation of the behavior of the system and of a workload regarding a comprehensive set of failure modes analyzed according to different dimensions. The emulation of software faults itself is done through the injection at machine-code level of selected mutations that represent the code produced when typical programming errors are made in the high-level language code. An important aspect of the proposed methodology is the use of simple and established practices to evaluate operating systems failure modes, thus allowing its use as a dependability benchmarking technique. The generalization of the methodology to any software system built of discrete and identifiable components is also discussed.
Quality of service management in IP networks

Quality of Service (QoS) in Internet Protocol (IF) Networks has been the subject of active research over the past two decades. Integrated Services (IntServ) and Differentiated Services (DiffServ) QoS architectures have emerged as proposed standards for resource allocation in IF Networks. These two QoS architectures support the need for multiple traffic queuing systems to allow for resource partitioning for heterogeneous applications making use of the networks. There have been a number of specifications or proposals for the number of traffic queuing classes (Class of Service (CoS)) that will support integrated services in IF Networks, but none has provided verification in the form of analytical or empirical investigation to prove that its specification or proposal will be optimum. Despite the existence of the two standard QoS architectures and the large volume of research work that has been carried out on IF QoS, its deployment still remains elusive in the Internet. This is not unconnected with the complexities associated with some aspects of the standard QoS architectures. [Continues. ]
Myocardial metabolism in diabetic cardiomyopathy: potential therapeutic targets.

SIGNIFICANCE Cardiovascular complications in diabetes are particularly serious and represent the primary cause of morbidity and mortality in diabetic patients. Despite early observations of cardiac dysfunction in diabetic humans, cardiomyopathy unique to diabetes has only recently been recognized. RECENT ADVANCES Research has focused on understanding the pathogenic mechanisms underlying the initiation and development of diabetic cardiomyopathy. Emerging data highlight the importance of altered mitochondrial function as a major contributor to cardiac dysfunction in diabetes. Mitochondrial dysfunction occurs by several mechanisms involving altered cardiac substrate metabolism, lipotoxicity, impaired cardiac insulin and glucose homeostasis, impaired cellular and mitochondrial calcium handling, oxidative stress, and mitochondrial uncoupling. CRITICAL ISSUES Currently, treatment is not specifically tailored for diabetic patients with cardiac dysfunction. Given the multifactorial development and progression of diabetic cardiomyopathy, traditional treatments such as anti-diabetic agents, as well as cellular and mitochondrial fatty acid uptake inhibitors aimed at shifting the balance of cardiac metabolism from utilizing fat to glucose may not adequately target all aspects of this condition. Thus, an alternative treatment such as resveratrol, which targets multiple facets of diabetes, may represent a safe and promising supplement to currently recommended clinical therapy and lifestyle changes. FUTURE DIRECTIONS Elucidation of the mechanisms underlying the initiation and progression of diabetic cardiomyopathy is essential for development of effective and targeted treatment strategies. Of particular interest is the investigation of alternative therapies such as resveratrol, which can function as both preventative and mitigating agents in the management of diabetic cardiomyopathy.
Test setup for accelerated test of high power IGBT modules with online monitoring of Vce and Vf voltage during converter operation

Several accelerated test methods exist in order to study the failures mechanisms of the high power IGBT modules like temperature cycling test or power cycles based on DC current pulses. The main drawback is that the test conditions do not represent the real performance and stress conditions of the device in real application. The hypothesis is that ageing of power modules closer to real environment including cooling system, full dc-link voltage and continuous PWM operation could lead to more accurate study of failure mechanism. A new type of test setup is proposed, which can create different real load conditions like in the field. Furthermore, collector-emitter voltage (Vce) has been used as indicator of the wear-out of the high power IGBT module. The innovative monitoring system implemented in the test setup is capable of measure the Vce and forward voltage of the antiparallel diode (Vf) during converter operation, which is also demonstrated.
Control of HLA‐A,B,C synthesis and expression in interferon‐treated cells.

Cytofluorimetric analyses with monoclonal antibodies were used to follow the specific effect of highly purified human leucocyte interferon (IFN‐alpha) on the expression of transplantation antigens (HLA)1 in Molt 4, a thymus leukaemia cell line. After a lag period of approximately 10 h the amount of HLA steadily increases to reach a maximum at day six of approximately 10 times its original. The effect is reversible and due to an increase in the rate of synthesis of HLA and beta 2m molecules as demonstrated by analysis of [35S]methionine incorporation into specific proteins after a 3‐h pulse of Molt 4 cells treated with IFN‐alpha for one or six days. A dramatic increase in the amount of mRNA that hybridised with a [32P]cDNA probe containing HLA sequences has also been demonstrated. Surface iodination of IFN‐treated Molt 4 cells showed an increase in the iodinated HLA and beta 2m chains and in addition another, apparently unrelated, component with an apparent mol. wt. of 16 000. This component, which appears after incubations with IFN‐alpha for longer than 1 h at 37 degrees C, was also detected in the B lymphoid cell lines RAJI and DAUDI.
Tracheal dilatation followed by stenosis in Mounier–Kuhn syndrome

A patient with previously undiagnosed Mounier–Kuhn syndrome (tracheobronchomegaly) was admitted with a head injury after a fall. The trachea was intubated with an oral tracheal tube with high‐volume low‐pressure cuff. The intracuff pressure was within the normal safe range recommended by the manufacturer. However, the patient developed tracheal dilatation on the second day after intubation. The trachea was extubated on the 15th day, and it was noticed 48 hours later that the patient was developing a tracheal stenosis at the site of the previous dilatation. The stenosis was so severe that the patient underwent resection‐anastomosis surgery of his stenotic tracheal segment 2 months after extubation. It may be preferable in patients with Mounier–Kuhn syndrome who require mechanical ventilation to intubate the trachea with an uncuffed tube and to pack the throat to decrease the chances of gas leak and inhalation.
Structured Literature Review of Electricity Consumption Classification Using Smart Meter Data

Smart meters for measuring electricity consumption are fast becoming prevalent in households. The meters measure consumption on a very fine scale, usually on a 15 min basis, and the data give unprecedented granularity of consumption patterns at household level. A multitude of papers have emerged utilizing smart meter data for deepening our knowledge of consumption patterns. This paper applies a modification of Okoli’s method for conducting structured literature reviews to generate an overview of research in electricity customer classification using smart meter data. The process assessed 2099 papers before identifying 34 significant papers, and highlights three key points: prominent methods, datasets and application. Three important findings are outlined. First, only a few papers contemplate future applications of the classification, rendering papers relevant only in a classification setting. Second; the encountered classification methods do not consider correlation or time series analysis when classifying. The identified papers fail to thoroughly analyze the statistical properties of the data, investigations that could potentially improve classification performance. Third, the description of the data utilized is of varying quality, with only 50% acknowledging missing values impact on the final sample size. A data description score for assessing the quality in data description has been developed and applied to all papers reviewed.
Transcriptional Basis for Hepatic Fibrosis in Cystic Fibrosis–associated Liver Disease

Objectives: Liver disease contributes to significant morbidity and mortality in cystic fibrosis (CF). Although all patients with CF express the defective CF transmembrane conductance regulator in cholangiocytes, many develop asymptomatic fibrosing liver disease. Only some develop cirrhosis, with pathogenesis remaining enigmatic. Available noninvasive diagnostic tools do not identify patients at risk before development of advanced fibrosis. We conducted a pilot study to identify genes associated with hepatic injury and fibrosis on liver biopsy that may help elucidate determinants of CF-associated liver disease (CFLD). Methods: Liver tissue from children with CFLD with various stages of hepatic fibrosis was compared with pediatric controls using cDNA array analysis. Differential expression of genes of interest was then assessed relative to pediatric control liver and non-CF cholestatic disease control liver from patients with biliary atresia, using both real-time reverse transcription-polymerase chain reaction and immunohistochemistry. Results: cDNA array demonstrated differential expression of numerous genes associated with hepatic fibrogenesis including collagens, matrix metalloproteinases, and chemokines in CFLD versus normal controls, particularly decreased expression in tissue remodeling genes including plasminogen activator inhibitor-1 (PAI-1, up to 25-fold) and tissue inhibitor of metalloproteinase-1 (TIMP-1); this was validated by real-time reverse transcription-polymerase chain reaction (PAI-1, P = 0.004; TIMP-1, P = 0.019). No significant decrease in PAI-1 or TIMP-1 mRNA was observed in biliary atresia versus normal control. Immunohistochemistry confirmed the decreased expression of hepatic PAI-1 and TIMP-1 protein in CFLD versus both normal and biliary atresia disease controls. Conclusions: The coordinated differential expression of these genes associated with liver fibrosis provides evidence for a transcriptional basis for the pathogenesis of CFLD and provides avenues for further study. Clarifying the pathogenesis of CFLD will facilitate techniques for early, precirrhotic detection and targeted interventions.
Compressive sensing of up-sampled model and atomic norm for super-resolution radar

Compressive sensing (CS) for radar signal processing is known to be capable of various applications. This signal processing technique shows excellent performance for detecting objects. However, the grid problem of CS is an obstacle to more precise performance. In this paper, we introduce two methods to overcome this grid problem and evaluate the performance of the methods. The first method is an up-sampled model, which is a method of dividing the grids into smaller pieces. The second method is an atomic norm minimization, which is a detectable method for continuous parameters.
Rendezvous Facilities: Concurrent C and the Ada Language

The concurrent programming facilities in both Concurrent C and the Ada language are based on the rendezvous concept. Although these facilities are similar, there are substantial differences. Facilities in Concurrent C were designed keeping in perspective the concurrent programming facilities in the Ada language and their limitations. Concurrent C facilities have also been modified as a result of experience with its initial implementations. The authors compare the concurrent programming facilities in Concurrent C and Ada and show that it is easier to write a variety of concurrent programs in Concurrent C than in Ada. >
E 1 A Deregulates the Centrosome Cycle in a Ran GTPase-dependent Manner 1

By means of the yeast two-hybrid system, we have discovered a novel physical interaction between the adenovirus E1A oncoprotein and Ran, a small GTPase which regulates nucleocytoplasmic transport, cell cycle progression, and mitotic spindle organization. Expression of E1A elicits induction of S phase and centrosome amplification in a variety of rodent cell lines. The induction of supernumerary centrosomes requires functional RCC1, the nucleotide exchange factor for Ran and, hence, a functional Ran network. The E1A portion responsible for the interaction with Ran is the extreme NH2-terminal region (amino acids 1–36), which is also required for the induction of centrosome amplification. In an in vitro assay with recombinant proteins, wild-type E1A interferes with nucleotide exchange on Ran, whereas an E1A mutant, deleted from the extreme NH2terminal region, does not. In addition, we detected an in vitro interaction between Ran and HPV-16 E7 and SV40 large T antigen, two oncoproteins functionally related to E1A. These findings suggest a common pathway of these oncoproteins in eliciting virus-induced genomic instability.
ARift Augmented Reality for the Oculus Rift DK 1

In this work we investigate the creation of an augmented reality environment using the Oculus Rift DK1 combined with two webcams, similar to what has been done by Steptoe et al. in [1]. First we recapitulate the definition of augmented reality and the general obstacles to overcome. Upon which we discuss the state of the art and move on to the specifics of this implementation of augmented reality. Finally we describe ongoing and propose future work building upon this realization.