Miracle-dz/UniFAR-FTUs huggingface dataset:
Flywheel Energy Storage Model, Control and Location for Improving Stability: The Chilean Case

A flywheel energy storage (FES) plant model based on permanent magnet machines is proposed for electro-mechanical analysis. The model considers parallel arrays of FES units and describes the dynamics of flywheel motion, dc-link capacitor, and controllers. Both unit and plant-level controllers are considered. A 50-MW FES plant model is tested in the Northern Chile Interconnected System (NCIS) when connected to the Argentinian Interconnected System (AIS). The FES plant provides transient support for primary frequency regulation and its impact on stability is studied using small-signal analysis and time domain simulations. To identify the best location to install the FES plant, eigenvalue sensitivity for the interarea mode is analyzed. The results are validated for different operation scenarios of wind and solar power. By installing the FES plant in the NCIS best location, the damping ratio of the interarea mode is increased from 0.53% to 13.1%. Moreover, the power transfer from the NCIS to the AIS can be augmented from 90 to 180 MW while still keeping the damping ratio above 9%. These findings are promising and may lead to useful planning criteria for energy storage deployment.
A comprehensive review on the phytochemical and pharmacological aspects of Podophyllum hexandrum: a high value medicinal plant

Podophyllum hexandrum Royle, a rhizomatous perennial herb from the Berberidaceae family, is a highly reputed medicinal plant known for its lignan, podophyllotoxin. Podophyllotoxin and its semisynthetic derivativatives are potent anticancer agents. The semisynthetic analogues of podophyllotoxin are also used in the treatment of lung cancer, testicular cancer, neuroblastoma, hepatoma and other tumor diseases. While Podophyllotoxin acts as an inhibitor of the microtubule assembly, the cytotoxic action of its derevatives is based on the inhibition of topoisomerase. Owing to the ever-increasing demand of Podophyllum hexandrum for podophyllotoxin, it has been subjected to heavy collection from the wild. The anti-cancer lignan derivative podophyllotoxin is biosynthesized at very low quantities in intact Podophyllum hexandrum plant and the whole plant is harvested to isolate the bioactive lignan adding to the threats that the plant is currently facing. Therefore, biotechnological production of podophyllotoxin has been considered essential. The present review gives a brief introduction about the phytochemistry, pharmacology and biosynthesis of podophyllotoxin and also discusses the potential of biotechnology for production of podophyllotoxin to meet the increasing demand of this highly valued plant metabolite.
Maryland Güvenli ve Destekleyici Okul İklim Ölçeği (Mgdoi)’Nin Türk Kültürüne Uyarlanması: Geçerlik ve Güvenirlik Çalışması

Bu arastirmanin amaci Maryland Guvenli ve Destekleyici Okul Iklim Olcegi (MGDOI)’nin Turkceye uyarlanmasi ve gecerlik ve guvenirliginin belirlenmesidir. Bu calismaya 395 lise ogrencisi katilmistir. MGDOI’nin yapi gecerliligini test etmek amaciyla dogrulayici faktor analizi yapilmistir. Olcegin ic tutarliligini belirlemek icin Cronbach Alpha katsayisi hesaplanmistir. Ayrica, olcegin cok duzeyli yapisi dikkate alinarak Mc Donald ω t ve Guttman λ 6 degerleri hesaplanmistir. Olcegin olcut dayanakli gecerliligini hesaplamak icin MGDOI ve Lise Yasam Kalitesi Olcegi (LYKO) arasindaki Pearson korelasyon katsayisi hesaplanmistir ve 0.65 olarak bulunmustur. Turkceye uyarlanan olcegin orijinal olcekle ayni alt boyutlara sahip oldugu bulunmustur. Ayrica veri analizi sonucunda MGDOI’nin Turk lise ogrencileri icin gecerli ve guvenilir oldugu gorulmustur.
Index compression for information retrieval systems

Dada la creciente cantidad de informacion disponible hoy en dia, existe una clara necesidad de sistemas de Recuperacion de Informacion (RI) que sean capaces de procesar esa informacion de una manera efectiva y eficiente, En este contexto, eficiente significa cantidad de tiempo y espacio requeridos para procesar datos, mientras que efectivo significa identificar de una manera precisa que informacion es relevante para el usuario y cual no lo es. Tradicionalmente, eficiencia y efectividad se encuentran en polos opuestos - lo que es beneficioso para la eficiencia, normalmente perjudica la efectividad y viceversa - asi que un reto para los sistemas de RI es encontrar un compromiso adecuado entre el procesamiento efectivo y eficiente de los datos. Esta tesis investiga el problema de la eficiencia de los sistemas de RI. Sugiere diferentes estrategias novedosas que pueden permitir la reduccion de los indices de los sistemas de RI, enmarcadas dentro da las tecnicas conocidas como compresion de indices. El indice es la estructura de datos que almacena la informacion utilizada en el proceso de recuperacion. Se presentan dos aproximaciones diferentes para la compresion de los indices, referidas como reordenacion de documentos y pruneado estatico del indice. Ambas aproximaciones explotan caracteristicas de colecciones de documentos para reducir el tamano final de los indices, mediante la reasignacion de los identificadores de los documentos de la coleccion o bien descartando selectivamente la informacion que es "menos relevante" para el proceso de recuperacion. Las estrategias de compresion propuestas en este tesis se pueden agrupar en dos categorias: (i) estrategias que extienden el estado del arte en la eficiencia de una manera novedosa y (ii) estrategias derivadas de propiedades relacionadas con los principios de la efectividad en los sistemas de RI; estas estrategias son novedosas porque son derivadas desde principios de la efectividad como contraposicion a los de la eficiencia, e porque revelan como la eficiencia y la efectividad pueden ser combinadas de una manera efectiva para la recuperacion de informacion. Las contribuciones de esta tesis abarcan la elaboracion de tecnicas del estado del arte en compresion de indices y tambien en la derivacion de tecnicas de compresion basadas en fundamentos teoricos derivados de los principios de la efectividad de los sistemas de RI. Todas estas tecnicas han sido evaluadas extensamente con numerosos experimentos que involucran conjuntos de datos y tecnicas de referencia bien establecidas en el campo, las cuales permiten una comparacion directa con el estado del arte. Finalmente, la optimalidad de las aproximaciones presentadas es tratada desde una perspectiva teorica.
On the Optimal Timing of Benefits with Heterogeneous Workers and Human Capital Depreciation

This paper studies the optimal timing of unemployment insurance subsidies in a McCall search model. Risk-averse workers sequentially sample random job opportunities. Our model distinguishes unemployment subsidies from consumption during unemployment by allowing workers to save and borrow freely. When the insurance agency faces a group of homogeneous workers solving stationary search problems, the optimal subsidies are independent of unemployment duration. In contrast, when workers are heterogeneous or when human capital depreciates during the spell, the optimal subsidy is no longer constant. We explore the main determinants of the shape of the optimal subsidy schedule, isolating forces for subsidies to optimally rise or fall with duration.
Nonlinear mitigation loop of a novel feedforward laser transmitter for radio over fiber link

The nonlinearity of a laser diode is a significant cause of limitation on the performance of every optical communication system especially in radio over fiber links considering radio frequency optically modulated signal. The amplitude and phase matching of a feedforward linearization loop is critical for optimum distortion reduction. In this paper, the influence of component parameters on the amplitude and phase matching of a novel feedforward laser transmitter design is presented employing a mathematical analysis and simulation with Optisystem 10.0. The mathematical and simulation results show that the system is influenced by fewer component parameters compared to previous works. This reduces the complexity of loop adjustment. In addition, the simulation results show that the system can reduce the third intermodulation distortion for up to 31 dB with the best achievable amplitude and phase matching.
RESeED: A secure regular‐expression search tool for storage clouds

Lack of trust has become one of the main concerns of users who tend to utilize one or multiple Cloud providers. Trustworthy Cloud‐based computing and data storage require secure and efficient solutions which allow clients to remotely store and process their data in the Cloud. User‐side encryption is an established method to secure the user data on the Cloud. However, using encryption, we lose processing capabilities, such as searching, over the Cloud data. In this paper, we present RESeED, a tool that provides user‐transparent and Cloud‐agnostic regular‐expression search functionality over encrypted data across multiple Clouds. Upon a client's intent to upload a new document to the Cloud, RESeED analyzes the document's content and updates its data structures accordingly. Then, it encrypts and transfers the document to the Cloud. RESeED provides the regular‐expression search functionality over encrypted data by translating the search queries on‐the‐fly to finite automata and analyzing concise and secure representations of the data before asking the Cloud to download the encrypted documents. RESeED's parallel architecture enables efficient search over large‐scale (and potentially big data scale) data‐sets. We evaluate the performance of RESeED experimentally and demonstrate its scalability and correctness using real‐world data‐sets from arXiv.org and Internet Engineering Task Force (IETF). Our results show that RESeED produces accurate query responses with a reasonable (≃6%) storage overhead. The results also demonstrate that for many search queries, RESeED performs faster in compare with the grep utility that functions on unencrypted data. Copyright © 2017 John Wiley & Sons, Ltd.
ENHANCED SECURITY IN PERSONALISED WEB SEARCH

 Abstract— Web search engine (WSE) provides massive amount of information . The aim of the WSE is to provide the relevant search result to the right user with the behavior of the queries they have given . Here the user privacy is under risk and also no securities were providing to their data. Personalized web search is done by adopting the Meta search approach which applies on one of the commercial search engine yahoo to execute a definite search. In order to derive personal favorite, the client is responsible for receiving the user's requests, submitting the requests to the web server, displaying the returned results and collecting profile details and search history. The server which is responsible for managing important tasks such as forwarding the requests to a commercial search engine, preparation and reranking of explore results before they returned to the client. The user's privacy is preserved by storing the user profiles for particular user on client's side. The server-client model is adopted in which user queries are forwarded to a server for making the training and reranking quickly. Privacy is preserved for both click-log based method and profile-based method. User's positive and negative feedback to improve the privacy is also considered. Here a working prototype of the clients on the yahoo platform is implemented
Association of p 53 Arg 72 Pro and MDM 2 SNP 309 polymorphisms with glioma

Epidemiological studies of the association of variants p53 Arg72Pro and MDM2 single-nucleotide polymorphism 309 (SNP309) with glioma risk have produced inconsistent results. The aim of the current study was to evaluate the association of these 2 variants with glioma susceptibility using a meta-analysis approach. For p53 Arg72Pro, 10 case-control studies including 2587 glioma patients and 4061 unrelated controls were identified. The pooled odds ratios (ORs) for Arg/Pro heterozygotes and Pro/Pro homozygotes were 1.08 [95% confidence interval (95%CI) = 0.85-1.37] and 1.08 (95%CI = 0.85-1.36), respectively, when compared to Arg/Arg carriers. Under the dominant effect model, Pro allele carriers also showed no significantly elevated glioma risk (pooled OR = 1.11, 95%CI =
The induction of atherogenic dyslipidaemia in poloxamer 407‐treated mice is not mediated through PPARα

The copolymer surfactant poloxamer 407 (P‐407) has been used to induce a dose‐controlled dyslipidaemia in both mice and rats. Human macrophages cultured with P‐407 exhibit a concentration‐dependent reduction in cholesterol efflux to apolipoprotein A1 (apoA1) due to down‐regulation of the ATP‐binding cassette transporter A1 (ABCA1). Peroxisome proliferator‐activated receptor alpha (PPARα) can increase expression of liver X receptor alpha (LXRα) in macrophages and thereby promote the expression of ABCA1, which, in turn, mediates cholesterol efflux to apoA1. This study investigated point(s) along this signalling pathway at which P‐407 might act to inhibit cholesterol efflux from macrophages. A transactivation assay was used to evaluate whether P‐407 could either activate PPARα or block the activation of PPARα by an established PPARα agonist. P‐407 was also evaluated for its potential to alter plasma lipid concentrations following its administration to both normal C57BL/6 and PPARα‐deficient mice. P‐407 was unable to modulate PPARα activity, as determined in cell‐based transactivation assays. Moreover, P‐407‐induced dyslipidaemia occurred at the same rate and to the same extent in PPARα‐deficient mice as was observed in C57BL/6 mice, suggesting no role for PPARα in P‐407‐mediated dyslipidaemia. Although PPARs are known to mediate the transcriptional regulation of the two major apolipoproteins associated with HDL (apoA1 and apoA2), P‐407 treatment resulted in a similar decrease (∼30%) in the plasma concentration of apoA1 in both control and PPARα‐deficient mice. Since our previous work demonstrated that P‐407 was unable to abrogate the capacity of a known LXRα agonist to increase cholesterol efflux from macrophages, P‐407 is likely to exert its effect, either directly or indirectly, on ABCA1, rather than on LXRα. On the basis of these findings it is concluded that PPARα does not mediate the P‐407‐dependent reduction in apoA1‐facilitated cholesterol efflux from macrophages.
Optical imaging in vitro provides evidence for the minicolumnar nature of cortical response

THE response of rat neocortical slices to electrical stimulation at the layer VI/white matter border was recorded using intrinsic signal optical imaging. The optical response of the slice is column-shaped, extends from layer VI to the pial surface, and is strongly correlated with the amplitude of simultaneously recorded evoked potentials. Spectral analysis revealed radially oriented spatial variations in the intensity of the optical signal with a period of 30–60 μm/cycle. Nissl-stained sections of slices also exhibited a radially oriented periodicity in optical density with the same period. We conclude that the periodic variations in the intrinsic optical signal correspond to stimulus-activated minicolumns.
Disparities in the Intensity of End-of-Life Care for Children With Cancer

This study reveals rates of and disparities in intense end-of-life care in pediatric oncology patients at the population level. BACKGROUND: Many adult patients with cancer who know they are dying choose less intense care; additionally, high-intensity care is associated with worse caregiver outcomes. Little is known about intensity of end-of-life care in children with cancer. METHODS: By using the California Office of Statewide Health Planning and Development administrative database, we performed a population-based analysis of patients with cancer aged 0 to 21 who died between 2000 and 2011. Rates of and sociodemographic and clinical factors associated with previously-defined end-of-life intensity indicators were determined. The intensity indicators included an intense medical intervention (cardiopulmonary resuscitation, intubation, ICU admission, or hemodialysis) within 30 days of death, intravenous chemotherapy within 14 days of death, and hospital death. RESULTS: The 3732 patients were 34% non-Hispanic white, and 41% had hematologic malignancies. The most prevalent intensity indicators were hospital death (63%) and ICU admission (20%). Sixty-five percent had ≥1 intensity indicator, 23% ≥2, and 22% ≥1 intense medical intervention. There was a bimodal association between age and intensity: ages <5 years and 15 to 21 years was associated with intense care. Patients with hematologic malignancies were more likely to have high-intensity end-of-life care, as were patients from underrepresented minorities, those who lived closer to the hospital, those who received care at a nonspecialty center (neither Children’s Oncology Group nor National Cancer Institute Designated Cancer Center), and those receiving care after 2008. CONCLUSIONS: Nearly two-thirds of children who died of cancer experienced intense end-of-life care. Further research needs to determine if these rates and disparities are consistent with patient and/or family goals.
Improving Energy Efficiency of Cooperative Femtocell Networks via Base Station Switching Off

Recently, energy efficiency (EE) of cellular networks has become an important performance metric, and several techniques have been proposed to increase the EE. Among them, turning off base stations (BSs) when not needed is considered as one of the most powerful techniques due to its simple operation and effectiveness. Herein, we propose a novel BS switching-off technique for cooperative femtocell networks where multiple femtocell BSs (FBSs) simultaneously send packets to the same mobile station (MS). Unlike conventional schemes, cooperative operation of FBSs, also known as coordinated multipoint (CoMP) transmission, is considered to determine which BSs are turned off in the proposed technique. We first formulate the optimization problem to find the optimal set of FBSs to be turned off. Then, we propose a suboptimal scheme operating in a distributed manner in order to reduce the computational complexity of the optimal scheme. The suboptimal scheme is based on throughput ratio (TR) which specifies the importance of a particular FBS for the cooperative transmission. Through simulations, we show that the energy consumption can be greatly reduced with the proposed technique, compared with conventional schemes. Moreover, we show that the suboptimal scheme also achieves the near-optimal performance even without the excessive computations.
Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model

Innate defense regulator (IDR) peptide-1002 is a synthetic host defense peptide derivative with strong anti-inflammatory properties. Extending previous data, IDR-1002 suppressed in vitro inflammatory responses in RAW 264.7 murine monocyte/macrophage cells challenged with the TLR4 agonist LPS and TLR2 agonists lipoteichoic acid and zymosan. To investigate the anti-inflammatory mechanisms of IDR-1002 in vivo, the PMA-induced mouse ear inflammation model was used. Topical IDR-1002 treatment successfully dampened PMA-induced ear edema, proinflammatory cytokine production, reactive oxygen and nitrogen species release, and neutrophil recruitment in the ears of CD1 mice. Advanced RNA transcriptomic analysis on the mouse ear transcriptome revealed that IDR-1002 reduced sterile inflammation by suppressing the expression of transmembrane G protein–coupled receptors (class A/1 rhodopsin-like), including receptors for chemokines, PGs, histamine, platelet activating factor, and anaphylatoxin. IDR-1002 also dampened the IFN-γ response and repressed the IFN regulatory factor 8–regulated network that controls central inflammatory pathways. This study demonstrates that IDR-1002 exhibits strong in vitro and in vivo anti-inflammatory activities, informs the underlying anti-inflammatory mechanisms, and reveals its potential as a novel therapeutic for inflammatory diseases.
Reliability of Au-Free AlGaN/GaN-on-Silicon Schottky Barrier Diodes Under ON-State Stress

In this paper, we report the results of an experimental analysis of the degradation induced by ON-state stress in GaN-based Schottky barrier diodes (SBDs). When a high stress current is applied to the device, turn-ON voltage (VTON), forward voltage (VF), and ON-resistance (RON) are affected by charge carrier trapping occurring at the AlGaN surface close to the anode corners and/or into the AlGaN barrier layer. We have investigated the degradation of SBDs under different stress conditions, analyzing the influence of temperature and voltage, investigating the activation energy of the traps, and hence the trapping mechanisms. In addition, thanks to this approach, the device lifetime has been evaluated, proving good device reliability.
Oral human β-defensin 2 in HIV-infected subjects with long-term use of antiretroviral therapy.

BACKGROUND The objectives of this study were to determine (i) oral hBD2 expression in HIV-infected subjects compared with non-HIV controls, (ii) the expression of oral hBD2 in HIV-infected subjects with antiretroviral therapy (ART) compared with those without ART, and (iii) factors associated with the expression of oral hBD2. METHODS Oral examination and punched biopsy on buccal mucosa were performed in HIV-infected subjects with and without ART, and non-HIV individuals. The expression of hBD2 mRNA was determined by quantitative real-time PCR. Saliva samples of both un-stimulated and stimulated saliva were collected and analyzed for hBD2 levels using ELISA. Student's t-test and nonparametric multi-way ANOVA test were used for comparison of measurements between or among groups. RESULTS One hundred and fifty-seven HIV-infected subjects were enrolled: 99 on ART (age range, 23-57 years; mean 39 years), 58 not on ART (age range, 20-59 years; mean 34 years), and 50 non-HIV controls (age range, 19-59 years; mean 36 years). The most common ART regimen was two nucleoside reverse transcriptase inhibitors + one non-nucleoside reverse transcriptase inhibitor. Salivary levels of hBD2 were significantly increased in HIV infection (P < 0.001). The levels of hBD2 in stimulated saliva were also found to be significantly different between HIV-infected subjects who were and were not on ART (P < 0.001). No significant difference was observed with the expression of hBD2 mRNA. CONCLUSION Oral innate immunity is affected by HIV infection and use of ART. Salivary hBD2 levels may be the useful biomarkers to monitor those on long-term ART who are at risk of developing oral infections and malignant transformation.
Low-Cardiac-Output Syndrome After Cardiac Surgery.

From the *Department of Anesthesiology and Intensive Care, Research Institute of Circulation Pathology, Novosibirsk, Russia; †Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, Arkhangelsk, Russia; and ‡Department of Cardiac Surgery, Research Institute of Circulation Pathology, Novosibirsk, Russia. Address reprint requests to Vladimir V. Lomivorotov, MD, PhD, Department of Anesthesiology and Intensive Care, Research Institute of Circulation Pathology, Rechkunovskaya 15 Street, 630055, Novosibirsk, Russia. E-mail: v.lomivorotov@gmail.com © 2016 Elsevier Inc. All rights reserved. 1053-0770/2601-0001$36.00/0 http://dx.doi. org/10.1053/j.jvca. 2016.05. 029