Miracle-dz/UniFAR-FTUs huggingface dataset:
Opposite role of infralimbic and prelimbic cortex in the tachycardiac response evoked by acute restraint stress in rats

The ventral medial prefrontal cortex (vMPFC) comprises the prelimbic cortex (PL) and the infralimbic cortex (IL). Conflicting results have been reported from studies aiming to investigate the role played by the vMPFC in behavioral and autonomic responses evoked in rodents exposed to experimental protocols that promote defense responses. Acute restraint is an unavoidable stress situation that evokes marked and sustained cardiovascular changes, which are characterized by elevated blood pressure (BP) and intense heart rate (HR) increases. We report here a comparison between the effects of pharmacological inhibition of IL and PL neurotransmission on BP and HR responses evoked by acute restraint in rats. Bilateral microinjection of 200 nl of the unspecific synaptic blocker CoCl2 (1 mM) into the PL increased HR response associated with restraint, without affecting the restraint‐induced BP response. However, when local synapses in the IL were inhibited by bilateral injection of CoCl2 into that area, the restraint‐induced HR increases were significantly reduced, without a significant effect on the concomitant BP response. No responses were observed when CoCl2 was microinjected into structures surrounding the vMPFC, such as the cingulate cortex area 1, the corpus callosum, or the tenia tecta. The present results confirm the involvement of the vMPFC in modulation of the tachycardiac response evoked by acute restraint but not of the restraint‐evoked blood pressure response. They also indicate that the IL and PL areas have opposite roles in the cardiac response, facilitating and reducing, respectively, restraint‐evoked tachycardiac responses. © 2009 Wiley‐Liss, Inc.
Maternal dietary fat intake during pregnancy is associated with infant temperament.

Research with rodents and nonhuman primates suggests that maternal prenatal dietary fat intake is associated with offspring behavioral functioning indicative of risk for psychopathology. The extent to which these findings extend to humans remains unknown. The current study administered the Automated Self-Administered 24 hr Dietary Recall Questionnaire three times in pregnancy (n = 48) to examine women's dietary fat intake in relation to infant temperament assessed using the Infant Behavior Questionnaire at 4-months old. The amount of saturated fat that the mother consumed was considered as a moderator of the association between total fat intake and child temperament. Results from a series of multiple linear regressions indicate that greater total fat intake was associated with poorer infant regulation and lower surgency. However, this second effect was moderated by maternal saturated fat intake, such that total fat intake was only related to infant surgency when mothers consumed above the daily recommended allowance of saturated fat. Under conditions of high total fat and high saturated fat, infants were rated as lower on surgency; under conditions of low total fat yet high saturated fat, infants were rated as higher on surgency. There were no associations between maternal prenatal fat intake and infant negative reactivity. These findings provide preliminary evidence that pregnant women's dietary fat intake is associated with infants' behavioral development, though future research is needed to address this report's limitations: a relatively small sample size, the use of self-report measures, and a lack of consideration of maternal and infant postnatal diet.
Employment Relationships and Firm Innovation: The Double Role of Human Capital

We examine how employment relationships and human capital influence innovation in a sample of Spanish firms. Previous research has indicated that human capital directly affects innovation, but few studies have considered human capital as a variable that mediates or moderates the effects of other variables on innovation. We tested our hypotheses using a sample of 150 innovative Spanish firms and confirmed that, while human capital favours innovations, employment relationships are not directly associated with innovation unless they take human capital into account. Specifically, our analyses suggest that human capital mediates the relationship between a mutual investment employment relationship and innovation, which is characterized by high levels of incentives and expectations. However, we also found that human capital plays a moderating role when organizations develop an employment relationship characterized by low investments in personnel but high expectations from their work (the underinvestment model). We discuss the theoretical and practical implications of these results.
Should pediatric emergency care be decentralized?: an out-of-hospital destination model for critically ill children.

OBJECTIVES A time-to-initial-stabilization model for out-of-hospital destinations of critically ill children (CICs) was developed. Application of this model to assess the impact of changes in different parameters of an emergency medical services for children (EMSC) system is described. METHODS A computer model created a 2,500-square-mile community containing ten community hospitals (CHs) and one pediatric critical care center (PCC). Community hospitals capable of providing initial immediate stabilization of CICs were defined as emergency departments accepting pediatrics (EDAPs). Critically ill children were randomly selected in proportion to population densities across the modeled community. Time to initial stabilization (TIS) was defined as the time to arrival at either an EDAP or a PCC or time to arrival at a non-EDAP CH + travel time for a team from the PCC to the non-EDAP CH + preparation/dispatch (P/D) time. The following parameters of the model were varied and their effect on TIS was evaluated: location of CHs, location of PCC, primary destinations for CICs, percent of CHs meeting EDAP standards, out-of-hospital compliance with designated hospitals for CICs, P/D time, and ambulance speed. RESULTS The computer model selected 1,000 CICs in accordance with the population densities of the community. The scenario with the shortest TIS was one in which every CH achieved EDAP designation (9.8 +/- 0.5 minutes). The scenario with the longest TIS involved a model in which every CIC was transported directly to the PCC (28.6 +/- 0.33 minutes). The number of EDAPs in a community and out-of-hospital compliance with use of EDAPs produced comparable effects on the TIS. Travel speeds had a direct effect on TIS but also exaggerated inefficiencies between scenarios. The P/D time had little effect on the TIS. CONCLUSIONS An out-of-hospital destination model has been developed with the ability to modify multiple EMSC system variables. Application of this model demonstrates the shortest times to stabilization of critically ill children occur in systems that maximize the number of hospitals that meet EDAP standards and decentralize pediatric emergency care.
Wishes to die in older people: a quantitative study of prevalence and associated factors.

BACKGROUND Death thoughts and wishes occur frequently among older people. In different European countries estimates of 10%-20% have been found. AIMS To determine the prevalence and associated factors of death thoughts and wishes among older people in The Netherlands. METHODS In The Netherlands 1794 people (58-98 years) were interviewed in 2005/2006 (Longitudinal Aging Study Amsterdam). RESULTS 81.3% reported never having death thoughts/wishes; 15.3% reported having had such thoughts/wishes; 3.4% reported currently having a wish to die and/or a weakened wish to continue living. Of those with a current wish to die, 67% had depressive symptoms (vs. 32% of people with death thoughts/wishes ever and 9% of people who never had had death thoughts/wishes), and 20% suffered from a depressive disorder (vs. 5% if death thoughts/wishes ever; 0.3% if never death thoughts/wishes). In a multivariate analysis, a current wish to die was associated with having depressive symptoms, a depressive disorder, lower perceived mastery, financial problems, loneliness, small network, involuntary urine loss, being divorced, and having a speech impediment. CONCLUSIONS Practical implications for health-care professionals are that they should be aware that in certain situations older people are more likely to develop a wish to die, and that a wish to die does not necessarily mean that someone has a depressive disorder. Nevertheless, it should serve as a trigger to investigate and to treat depression if present.
Utility of data from a national health survey: Do socioeconomic inequalities in morbidity exist in Serbia?

Aims: The aim of this study was to analyse the impact of demographic and socioeconomic factors on morbidity in Serbia. Additionally, knowing that there is no a gold standard for measuring morbidity we were concerned whether the results of this study depend on the choice of morbidity indicator. Methods: Data from the 2006 National Health Survey for Serbia were used. A representative sample of 14,522 persons aged ≥20 years were interviewed. The associations between demographic factors (age, gender, marital status, and type of settlement), socioeconomic indicators (education and wealth index), and health status (morbidity index derived from self-reported data) were examined using linear and logistic regression analyses. Results: Women, elderly people, those who live in urban settings, and those with lower education had higher morbidity regardless of using a morbidity index as a continuous variable (composite index ranging from 0 to 20) or a categorical variable (morbidity status tertiles). Respondents who belong to the most deprived group had higher scores of morbidity index in comparison with the respondents from the most affluent group, but no significant association was found when morbidity status was examined as the outcome. In addition, when those who belong to the middle class group were compared to the most affluent group, they had good more frequently than average morbidity status. Conclusions: This study suggests that demographic and socioeconomic inequalities in morbidity exist in Serbia. Wise and comprehensive health policies and interventions for reducing these inequalities are urgently needed which primarily focus on the most disadvantaged socioeconomic groups.
Are stock returns related toshort-term and long-term past returns? Australian evidence

The purpose of this article is to identify whether there is a short-term continuation of returns and a long-term reversal of returns in an Australian setting and to subsequently investigate if the Capital Asset Pricing Model (hereafter CAPM) and the Fama and French (1993) three factor model (hereafter FFM) are capable of explaining these anomalies. We find a short-term continuation of returns but not a long-term reversal of returns. We also find that both models fail to explain the short-term continuation in returns. However, the FFM yields higher explanatory power than the CAPM.
Inflammatory breast cancer: dynamic contrast-enhanced MR in patients receiving bevacizumab--initial experience.

PURPOSE To retrospectively compare three dynamic contrast material-enhanced magnetic resonance (MR) imaging (dynamic MR imaging) analytic methods to determine the parameter or combination of parameters most strongly associated with changes in tumor microvasculature during treatment with bevacizumab alone and bevacizumab plus chemotherapy in patients with inflammatory or locally advanced breast cancer. MATERIALS AND METHODS This study was conducted in accordance with the institutional review board of the National Cancer Institute and was compliant with the Privacy Act of 1974. Informed consent was obtained from all patients. Patients with inflammatory or locally advanced breast cancer were treated with one cycle of bevacizumab alone (cycle 1) followed by six cycles of combination bevacizumab and chemotherapy (cycles 2-7). Serial dynamic MR images were obtained, and the kinetic parameters measured by using three dynamic analytic MR methods (heuristic, Brix, and general kinetic models) and two region-of-interest strategies were compared by using two-sided statistical tests. A P value of . 01 was required for significance. RESULTS In 19 patients, with use of a whole-tumor region of interest, the authors observed a significant decrease in the median values of three parameters measured from baseline to cycle 1: forward transfer rate constant (Ktrans) (-34% relative change, P=.003), backflow compartmental rate constant extravascular and extracellular to plasma (Kep) (-15% relative change, P<.001), and integrated area under the gadolinium concentration curve (IAUGC) at 180 seconds (-23% relative change, P=.009). A trend toward differences in the heuristic slope of the washout curve between responders and nonresponders to therapy was observed after cycle 1 (bevacizumab alone, P=.02). The median relative change in slope of the wash-in curve from baseline to cycle 4 was significantly different between responders and nonresponders (P=.009). CONCLUSION The dynamic contrast-enhanced MR parameters Ktrans, Kep, and IAUGC at 180 seconds appear to have the strongest association with early physiologic response to bevacizumab. Clinical trial registration no. NCT00016549
Interpreting and Answering Keyword Queries using Web Knowledge Bases

Many keyword queries issued to Web search engines target information about real world entities, and interpreting these queries over Web knowledge bases can allow a search system to provide exact answers to keyword queries. Such an ability provides a useful service to end users, as their information need can be directly addressed and they need not scour textual results for the desired information. However, not all keyword queries can be addressed by even the most comprehensive knowledge base, and therefore equally important is the problem of recognizing when a reference knowledge base is not capable of modelling the keyword query’s intention. This may be due to lack of coverage of the knowledge base or lack of expressiveness in the underlying query representation formalism. This thesis presents an approach to computing structured representations of keyword queries over a reference knowledge base. Keyword queries are annotated with occurrences of semantic constructs by learning a sequential labelling model from an annotated Web query log. Frequent query structures are then mined from the query log and are used along with the annotations to map keyword queries into a structured representation over the vocabulary of a reference knowledge base. The proposed approach exploits coarse linguistic structure in keyword queries, and combines it with rich structured query representations of information needs. As an intermediate representation formalism, a novel query language is proposed that blends keyword search with structured query processing over large Web knowledge bases. The formalism for structured keyword queries combines the flexibility of keyword search with the expressiveness of structures queries. A solution to the resulting disambiguation problem caused by introducing keywords as primitives in a structured query language is presented. Expressions in our proposed language are rewritten using the vocabulary of the knowledge base, and different possible rewritings are ranked based on their syntactic relationship to the keywords in the query as well as their semantic coherence in the underlying knowledge base. The problem of ranking knowledge base entities returned as a query result is also explored from the perspective of personalized result ranking. User interest models based on entity types are learned from a Web search session by cross referencing clicks on URLs with known entity homepages. The user interest model is then used to effectively rerank answer lists for a given user. A methodology for evaluating entity-based search engines is also proposed and empirically evaluated.
DNA gyrase, CS7.4, and the cold shock response in Escherichia coli

We identify the A subunit of DNA gyrase as a cold shock protein whose synthesis is sustained following transfer of exponentially growing cultures of Escherichia coli from 37 to 10 degrees C. After a lag period in which its synthetic rate declines, synthesis of the A subunit of DNA gyrase increases relative to that of total protein. The duration of the lag period in synthesis and the synthetic rate of the A subunit appear dependent on the synthesis of a rapidly induced cold shock protein, CS7.4. The promoter of the gyrA gene contains specific binding sites for the CS7.4 protein, suggesting that CS7.4 acts at the transcriptional level to facilitate continued A-subunit synthesis. As synthesis of the B subunit of DNA gyrase is also sustained during cold shock, we suggest that an increase in the amount of DNA gyrase per cell might occur, which would potentially adapt the cells for growth at reduced temperatures (10 degrees C).
Evidence for zoonotic transmission of group C rotaviruses among children in Belém, Brazil

The prevalence and potential zoonotic transmission of group C rotavirus (RVC) were examined by testing fecal samples collected from children during a longitudinal study that was carried out in the outskirts of Belém, Brazil, from December 1982 to March 1986. The study involved a group of 30 children who were followed from birth to 3 years. Of the 77 samples tested from 29 children, 5 (6.5%) were positive for human and 3 (4%) for porcine RVC by using nested PCR assay with primers specific for VP6 gene of human or porcine RVC and by Southern hybridization using a probe specific for VP6 gene of both human and porcine RVC. In addition, a total of 59 fecal specimens from the 30th child were tested, 1 (1.7%) and 14 (23.7%) were positive for human and porcine RVC, respectively. Partial nucleotide sequences of VP6 gene demonstrated that the six human strains detected in Brazil were homologous with other human RVC, and 14 of the 17 porcine RVC strains examined showed a complete homology among themselves but differed slightly from the porcine Cowden strain, suggesting that a single porcine RVC strain was circulating in Belém. This study is the first to provide evidence for transmission of RVC from swine to human. They also indicate that both human and porcine RVC were endemic in Belém. J. Med. Virol. 80:1666–1674, 2008. © 2008 Wiley‐Liss, Inc.
The cobY Gene of the Archaeon Halobacterium sp. Strain NRC-1 Is Required for De Novo Cobamide Synthesis

ABSTRACT Genetic and nutritional analyses of mutants of the extremely halophilic archaeon Halobacterium sp. strain NRC-1 showed that open reading frame (ORF) Vng1581C encodes a protein with nucleoside triphosphate:adenosylcobinamide-phosphate nucleotidyltransferase enzyme activity. This activity was previously associated with the cobY gene of the methanogenic archaeon Methanobacterium thermoautotrophicum strain ΔH, but no evidence was obtained to demonstrate the direct involvement of this protein in cobamide biosynthesis in archaea. Computer analysis of the Halobacterium sp. strain NRC-1 ORF Vng1581C gene and the cobY gene of M. thermoautotrophicum strain ΔH showed the primary amino acid sequence of the proteins encoded by these two genes to be 35% identical and 48% similar. A strain of Halobacterium sp. strain NRC-1 carrying a null allele of the cobY gene was auxotrophic for cobinamide-GDP, a known intermediate of the late steps of cobamide biosynthesis. The auxotrophic requirement for cobinamide-GDP was corrected when a wild-type allele of cobY was introduced into the mutant strain, demonstrating that the lack of cobY function was solely responsible for the observed block in cobamide biosynthesis in this archaeon. The data also show that Halobacterium sp. strain NRC-1 possesses a high-affinity transport system for corrinoids and that this archaeon can synthesize cobamides de novo under aerobic growth conditions. To the best of our knowledge this is the first genetic and nutritional analysis of cobalamin biosynthetic mutants in archaea.
Shoulder joint position sense improves with elevation angle in a novel, unconstrained task

Proprioception, encompassing the submodalities of kinesthesia and joint position sense, is important in the maintenance of joint stability, especially in the shoulder. The purpose of this study was to examine the effects of plane and elevation angle on unconstrained shoulder joint position sense. Twenty‐two subjects (12 male, 10 female) without a history of shoulder pathology were recruited from a university campus. Subjects attempted to replicate, with respect to plane and elevation angles, various target positions. Target positions consisted of five plane angles at 90° of arm elevation and five arm elevation angles in the scapular plane. All target positions were tested twice to assess the reliability of the measurement. Intraclass correlation coefficients were generally low across target positions, possibly owing to the novelty and demanding nature of the task. No differences in repositioning errors were observed between plane angles (p = 0.255). Repositioning errors decreased linearly as the elevation angle increased from 30° to 90° (p = 0.007) and increased again from 90° to 110° of elevation (p = 0.029). Our results suggest that unconstrained joint position sense may be enhanced with increased muscular activation levels. Further, afferent feedback from musculotendinous mechanoreceptors may dominate over that from capsuloligamentous sources in unconstrained movements. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 24:559–568, 2006
Self-Reported Gastrointestinal Symptoms in Type 2 Diabetes Improve With an Intensive Lifestyle Intervention: Results From the Action for Health in Diabetes (Look AHEAD) Clinical Trial

In Brief This article reports on an investigation of whether an intensive lifestyle intervention (ILI) would reduce gastrointestinal symptoms over 4 years of follow-up for participants in the Action for Health in Diabetes (Look AHEAD) trial compared to a diabetes support and education (DSE) group. Look AHEAD is a randomized, multicenter trial comparing overweight and obese adults with type 2 diabetes treated with ILI versus DSE. ILI, and weight loss in general, had beneficial effects on gastrointestinal (GI) symptoms, with some variability in the strength of the effect depending on the specific symptom and time course. Potential modifiers were analyzed, yet ILI retained an association with improvement in GI symptoms.
Laser collimation of a continuous beam of cold atoms using Zeeman-shift degenerate-Raman-sideband cooling

In this article we report on the use of degenerate-Raman-sideband cooling for the collimation of a continuous beam of cold cesium atoms in a fountain geometry. Thanks to this powerful cooling technique we have reduced the atomic beam transverse temperature from $60\phantom{\rule{0.3em}{0ex}}\ensuremath{\mu}\mathrm{K}\phantom{\rule{0.5em}{0ex}}\text{to}\phantom{\rule{0.5em}{0ex}}1.6\phantom{\rule{0.3em}{0ex}}\ensuremath{\mu}\mathrm{K}$ in a few milliseconds. The longitudinal temperature of $80\phantom{\rule{0.3em}{0ex}}\ensuremath{\mu}\mathrm{K}$ is not modified. The flux density, measured after a parabolic flight of $0.57\phantom{\rule{0.3em}{0ex}}\mathrm{s}$, has been increased by a factor of 4 to approximately ${10}^{7}\phantom{\rule{0.3em}{0ex}}\mathrm{at. }\phantom{\rule{0.2em}{0ex}}{\mathrm{s}}^{\ensuremath{-}1}\phantom{\rule{0.2em}{0ex}}{\mathrm{cm}}^{\ensuremath{-}2}$ and we have identified a Sisyphus-like precooling mechanism which should make it possible to increase this flux density by an order of magnitude.