Miracle-dz/UniFAR-FTUs huggingface dataset:
Noise spectroscopy of traps in silicon nanowire field-effect transistors

We investigated noise spectra of strained nanowire field-effect transistors with cross-section of 42×42nm2. Analysis of the flicker noise component behavior enabled us to evaluate the volume trap density at different locations of the nanowire cross-section. The measured value is not higher than that in conventional planar transistors. As the result of the Lorentzian noise component investigation we have estimated that the position of the single active trap in gate oxide dielectric is at a depth of 0.6 nm.
Transition into an Emergency Nurse Practitioner: A Sharing of Self-Reflection

The role of the Emergency Nurse Practitioner (ENP) has been established in other countries for a few decades, such as the United Kingdom (UK) and the United States where it has developed rapidly in these countries. The concept of the nurse practitioner is to empower those nurses who have a sound clinical base and specialty skills to enable them to make autonomous judgements and decisions regarding patient care. Evidence shows that the expanded role enables greater continuity and consistency in the delivery of “holistic care”. Moreover, the ENP service also helps the accident & emergency department to be more effective in its use of available nursing and medical resources. In view of the situation in Hong Kong, because of the unsatisfactory primary health care system, health care providers in emergency care have to deal with huge numbers of patients with minor illnesses and injuries. Patients in this category have to wait for long periods to see a doctor. So the development of the role of ENP for the management of minor injury would be a good option to better utilise departmental manpower to meet patient needs. The author has finished training for minor injury in UK which prepared emergency nurses to take up the ENP role in accident & emergency departments. In this article, the author will share her ENP training experience in the whole process of learning.
Weighted averaging in spectroscopic studies improves statistical power

In vivo MRS is often characterized by a spectral signal‐to‐noise ratio (SNR) that varies highly between experiments. A common design for spectroscopic studies is to compare the ratio of two spectral peak amplitudes between groups, e.g. individual PCr/γ‐ATP ratios in 31P‐MRS. The uncertainty on this ratio is often neglected. We wished to explore this assumption.
TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog

Williams-Beuren syndrome (WBS) is a developmental disorder with multi-system manifestations caused by haploinsufficiency for contiguous genes deleted in chromosome region 7q11.23. The size of the deletion is similar in most patients due to a genomic duplication that predisposes to unequal meiotic crossover events. While hemizygosity at the elastin locus is responsible for the cardiovascular features, the contribution of other genes to the WBS phenotype remains to be demonstrated. We have identified a novel gene, TBL2, in the common WBS deletion. TBL2 is expressed as a 2.4-kb transcript predominantly in testis, skeletal muscle, heart and some endocrine tissues, with a larger ∼5-kb transcript detected ubiquitously at lower levels. TBL2 encodes a protein with four putative WD40-repeats. An alternatively spliced transcript in TBL2 introduces a novel second exon with an in frame stop codon. This mRNA encodes a 75 amino acid protein with 43 amino acids identical to TBL2 at the N-terminus and no known functional domain. The mouse homolog, Tbl2, shows 84% sequence identity at the nucleotide level and 92% similarity at the amino acid level. Comparison of the mouse and human sequences identifies a conserved region that extends upstream of the previously published sequence with an initiation codon common to both species that adds 21 amino acids at the N-terminus. The Tbl2 gene has been mapped to mouse chromosome 5 in a region of conserved synteny with human 7q11.23. Since haploinsufficiency has been shown for other WD-repeat containing proteins, hemizygosity of TBL2 may contribute to some of the aspects of the complex WBS phenotype.
Incremental String Comparison

The problem of comparing two sequences A and B to determine their longest common subsequence (LCS) or the edit distance between them has been much studied. In this paper we consider the following incremental version of these problems: given an appropriate encoding of a comparison between A and B, can one incrementally compute the answer for A and bB, and the answer for A and Bb with equal efficiency, where b is an additional symbol? Our main result is a theorem exposing a surprising relationship between the dynamic programming solutions for two such "adjacent" problems. Given a threshold k on the number of differences to be permitted in an alignment, the theorem leads directly to an O(k) algorithm for incrementally computing a new solution from an old one, as contrasts the O(k2) time required to compute a solution from scratch. We further show, with a series of applications, that this algorithm is indeed more powerful than its nonincremental counterpart. We show this by solving the applications with greater asymptotic efficiency than heretofore possible. For example, we obtain O(nk) algorithms for the longest prefix approximate match problem, the approximate overlap problem, and cyclic string comparison.
Diagnosis of urogenital Chlamydia trachomatis infection in women based on mailed samples obtained at home: multipractice comparative study

Abstract Objective: To compare urine and vaginal flush samples collected by women at home with endocervical and urethral swabs obtained by general practitioners for their efficacy in the diagnosis of urogenital Chlamydia trachomatis infection. Design: Multipractice comparative study. Setting: 33 general practices and a central department of clinical microbiology in Aarhus County, Denmark. Subjects: 222 women aged 18–25 years who for any reason had a gynaecological examination. Interventions: Endocervical and urethral swabs were obtained by the women's general practitioners. The same women when at home then collected a first void urine sample, a midstream urine sample, and a vaginal flush sample (using a vaginal pipette) and mailed them to the laboratory. Main outcome measures: C trachomatis detected by the polymerase chain reaction and the ligase chain reaction. Eight tests for C trachomatis were performed for every woman. When two of the eight yielded positive results the patient was considered infected. Results: The overall prevalence of C trachomatis infection was 11.2% (23/205 women). Test sensitivities in samples obtained by general practitioners, samples obtained at home subjected to polymerase chain reaction, and samples obtained at home subjected to ligase chain reaction were 91%, 96%, and 100% respectively. The corresponding specificities were 100%, 92.9%, and 99.5%. Conclusions: The diagnostic efficacy of samples obtained by women at home and mailed to the laboratory was as good as for samples obtained by a general practitioner when using the ligase chain reaction. This may have important implications for the practicability of screening for this common, often asymptomatic, and treatable infection. Key messages A combination of mailed samples obtained at home is necessary in order to obtain optimal diagnostic sensitivity; a single urine sample is not enough Mailed samples obtained at home may also be appropriate for diagnosis in young asymptomatic women with regular partners; these women have a high prevalence of urogenital C trachomatis infection The use of mailed self obtained samples in women might limit costs and increase the practicability of screening programmes for urogenital C trachomatis infection
BugSifter: A Generalized Accelerator for Flexible Instruction-Grain Monitoring

Software robustness is an ever-challenging problem in the face of today's evolving software and hardware that has undergone recent shifts. Instruction-grain monitoring is a powerful approach for improved software robustness that affords comprehensive runtime coverage for a wide spectrum of bugs and security exploits. Unfortunately, existing instruction-grain monitoring frameworks, such as dynamic binary instrumentation, are either prohibitively expensive (slowing down applications by an order of magnitude or more) or offer limited coverage. This work introduces BugSifter, a new design that drastically decreases monitoring overhead without sacrificing flexibility or bug coverage. The main overhead of instruction-grain monitoring lies in execution of software event handlers to monitor nearly every application instruction to check for bugs. BugSifter identifies common monitoring activities that result in redundant monitoring actions, and filters them using general, light-weight hardware, eliminating the majority of costly software event handlers. Our proposed design filters 80-98% of events while monitoring for a variety of commonly-occurring bugs, delegating the rest to flexible software handlers. BugSifter significantly reduces the overhead of instruction-grain monitoring to an average of 40% over unmonitored application time. BugSifter makes instruction-grain monitoring practical, enabling efficient and timely detection of a wide range of bugs, thus making software more robust.
Supercapacitor Module SAM for Hybrid Busses: an Advanced Energy Storage Specification based on Experiences with the TOHYCO-Rider Bus Project

In summer 2004 and 2006 the TOHYCO-Ridera bus with supercapacitors and IPTb was operated by the IIEEC for public transport services in Lucerne. A second generation version of a supercapacitor storage SAMd was implemented and tested. A very important step in industrializing hybrid vehicles with SAM became fulfilled. The quite unique combination of a drive-chain system by means of supercapacitors and IPT, the project experiences and the issue on the efficient energy use are presented in this paper. Also the specification of a new SAM is discussed in detail. The future SAM has to be designed in a way that it is open enough for different drive systems on the market. In two main topics of the paper the concept includes technical aspects of combining supercapacitors within the balancing circuitry as well as a CAN-bus interface that make it more easy to integrate an adequate energy-management. Finally, the significance for new hybrid-bus projects will be pointed-out.
Risk of first non-fatal myocardial infarction negatively associated with olive oil consumption: a case-control study in Spain.

BACKGROUND Olive oil is the main source of dietary lipids in most Mediterranean countries where mortality and incidence rates for coronary heart disease (CHD) are the lowest in Europe. Although international comparisons and mechanistic reasons support the hypothesis that a high olive oil intake may prevent CHD, limited data from studies of individuals are available. METHODS A hospital-based case-control study was conducted in Pamplona (Spain) recruiting 171 patients (81% males, age <80 years) who suffered their first acute myocardial infarction and 171 age-, gender- and hospital-matched controls (admitted to minor surgery, trauma or urology wards). A validated semi-quantitative food frequency questionnaire (136 items) was used to appraise previous long-term dietary exposures. The same physician conducted the face-to-face interview for each case patient and his/her matched control. Conditional logistic regression modelling was used to take into account potential dietary and non-dietary confounders. RESULTS The exposure to the upper quintile of energy-adjusted olive oil (median intake: 54 g/day) was associated with a statistically significant 82% relative reduction in the risk of a first myocardial infarction (OR = 0.18; 95% CI : 0.06-0.63) after adjustment for dietary and non-dietary confounders. CONCLUSIONS Our data suggest that olive oil may reduce the risk of coronary disease. These findings require confirmation in further observational studies and trials.
Conservatism and Attitudes toward Suicide: A Study of Taiwanese-American and U.S. Adults

The Suicide Opinion Questionnaire and the Conservatism scale were administered to two samples of respondents: Eighty-two Taiwanese-Americans and eighty-two United States adults, of comparable gender, age, and geographical location. The results indicated significant differences on seven of the eight SOQ scales, as well as significant differences in conservatism. In both samples, the pattern of correlations between conservatism and attitudes toward suicide was highly similar, with more conservative individuals perceiving suicide as related to mental illness, religion, and moral evil, and less so as a right to die. In both samples, significant differences in attitudes toward suicide were reflected between those self-identified as suicide ideators and those not so identified.
Two-level regression of body mass distribution from X-ray image database

In this paper, we propose a novel two-level regression method for computing body mass distribution from a database of X-ray images, without scanning the new subject. Our approach first selects a suitable sample from the image database by minimizing a distance function based on the relationships between the new subject's body measurements and those of sample subjects. The X-ray image of the new subject is then predicted from the sample image using a feature-based transformation. Body mass distribution is computed directly from the predicted X-ray image. Our results surpass the accuracy of commonly used mass distribution regression methods in biomechanics literatures. In addition, by not scanning the new subject, we avoid all the radiation and cost involved in X-ray absorptiometry.
Repression-sensitization, gender, and discrepancies in psychobiological reactions to examination stress

Psychobiological responses to examination stress in repressors and sensitizers have rarely been investigated with respect to intraindividual response discrepancies. Furthermore, possible sex differences have rarely been taken into consideration. Therefore the present study investigated if repressors and sensitizers differ in their psychobiological responses to stress and if gender plays a modulating role. 30 and 29 students of both sexes selected from a total group of 96 students were classified as repressors or sensitizers each according to the repression-sensitization-coping-inventory (RSCI, Huwe et al.). State anxiety, heart rate, and cortisol in saliva served as indicators of stress. Sensitizers reported higher state anxiety and showed higher physiological stress responses than repressors. On the intraindividual level sensitizers reported high anxiety as compared to their low cortisol responses whereas repressors reported low anxiety as compared to their high cortisol increases. Gender had no modulating influence on stress responses in repressors and sensitizers.
Role of human chromosome 11 in determining surface antigenic phenotype of normal and malignant cells. Somatic cell genetic analysis of eight antigens, including putative human Thy-1

The expression of eight serologically and biochemically distinct human cell surface antigens defined by monoclonal antibodies was examined on a panel of rodent-human somatic cell hybrids. Cosegregation was observed for human chromosome 11, and surface expression of all eight antigens was studied. Serological analysis of hybrids containing defined segments of human chromosome 11 permitted the regional assignment of genes controlling antigens JF23 (90 kD glycoprotein), G344 (25 kD), T43 (85 kD), A124, and NP13 to chromosome 11pter-q13, and of genes controlling Q14 (130 kD), MC139 (35 kD), and K117 (25 kD) to chromosome 11q13-qter. K117, the putative human Thy-1 antigen, was expressed at high levels in chromosome 11-containing hybrids constructed with mouse neuroblastoma cells, but showed little or no expression in hybrids constructed with mouse L cells. A similar pattern of expression in hybrids was found for MC139, an antigen shared by neuroectoderm-derived cells and normal and malignant T lymphocytes. T43 is a marker of malignant tumors (but not benign tumors) derived from a number of T43- epithelia, and the regional assignment of the T43 locus on chromosome 11 raises questions about its possible involvement in the specific rearrangements of this chromosome seen in human malignancies.
Maximum-likelihood parameter estimation of bilinear systems

This paper addresses the problem of estimating the parameters in a multivariable bilinear model on the basis of observed input-output data. The main contribution is to develop, analyze, and empirically study new techniques for computing a maximum-likelihood based solution. In particular, the emphasis here is on developing practical methods that are illustrated to be numerically reliable, robust to choice of initialization point, and numerically efficient in terms of how computation and memory requirements scale relative to problem size. This results in new methods that can be reliably deployed on systems of nontrivial state, input and output dimension. Underlying these developments is a new approach (in this context) of employing the expectation-maximization method as a means for robust and gradient free computation of the maximum-likelihood solution.
Newborn Screening: What Does the Emergency Physician Need to Know?

Abstract Newborn screening programs were established in the United States in the early 1960s. Newborn screening programs were then developed by states and have continued to be the responsibility of the state. All states require a newborn screening, but what is required of these programs and screening panels has differed greatly by state. Historically, the most commonly screened disorders are the following: congenital hypothyroidism, congenital adrenal hyperplasia, sickle cell disease and associated hemoglobinopathies, biotinidase deficiency, galactosemia, cystic fibrosis and phenylketonuria, maple syrup urine disease, and homocystinuria. However, under new guidelines in 2006 and with new advances in technology, the scope of newborn screening programs has expanded to include at a minimum 9 organic acidurias, 5 fatty acid oxidation disorders, 3 hemoglobinopathies, and 6 other conditions. This CME article reviews the logistics of newborn screening and explores the effect of new technology and recent policy on state screens and what that means for providers. This article also highlights several of the disorders most relevant to emergency room physicians and discusses future considerations of newborn screening.
Quality of life in women with cervical precursor lesions and cancer: a prospective, 6-month, hospital-based study in China

The overall survival of patients with cervical cancer has improved due to detection at an early stage and availability of comprehensive treatments in China. As patients' lives prolonged, it is important to understand their health-related quality of life (QoL) during and after treatment. We used the EQ-5D questionnaire to assess QoL of 194 patients with cervical lesions at Sichuan University West China Second Hospital between May 2010 and January 2011. Patients were surveyed before primary treatment and at 1, 3, and 6 months after primary treatment. Results showed a consistent decline in EQ-5D scores in the spectrum of cervical lesions at each time point after treatment (all P < 0.05). For patients with precursor lesions, there was an increasing trend along the timeline of treatment (P < 0.01). For patients with early-stage cervical cancer, EQ-5D scores declined in the first month (P = 0.01) and gradually increased to higher levels at 6 months post-treatment than those before treatment (P < 0.01). EQ-5D scores followed a similar trend in patients with advanced cervical cancer (P = 0.04), though they did not statistically rebound after 6 months (0.84 ± 0.19 vs. 0.86 ± 0.11, P = 0.62). Regarding advanced cervical cancer, EQ-5D scores for women above 40 years of age appeared to recover more rapidly and reached higher levels than those for women below 40 years (P = 0.03). Caution and extra care are recommended in the early period of cervical cancer treatment given the slight deterioration in the QoL, and in particular, for younger cervical cancer patients. Our study implies that health care providers may need to improve the health-related QoL of cervical cancer patients.
Generation of CD20-specific TCRs for TCR gene therapy of CD20low B-cell malignancies insusceptible to CD20-targeting antibodies

Immunotherapy of B-cell leukemia and lymphoma with CD20-targeting monoclonal antibodies (mAbs) has demonstrated clinical efficacy. However, the emergence of unresponsive disease due to low or absent cell surface CD20 urges the need to develop additional strategies. In contrast to mAbs, T-cells via their T-cell receptor (TCR) can recognize not only extracellular but also intracellular antigens in the context of HLA molecules. We hypothesized that T-cells equipped with high affinity CD20-targeting TCRs would be able to recognize B-cell malignancies even in the absence of extracellular CD20. We isolated CD8+ T-cell clones binding to peptide-MHC-tetramers composed of HLA-A*02:01 and CD20-derived peptide SLFLGILSV (CD20SLF) from HLA-A*02:01neg healthy individuals to overcome tolerance towards self-antigens such as CD20. High avidity T-cell clones were identified that readily recognized and lysed primary HLA-A2pos B-cell leukemia and lymphoma in the absence of reactivity against CD20-negative but HLA-A2pos healthy hematopoietic and nonhematopoietic cells. The T-cell clone with highest avidity efficiently lysed malignant cell-lines that had insufficient extracellular CD20 to be targeted by CD20 mAbs. Transfer of this TCR installed potent CD20-specificity onto recipient T-cells and led to lysis of CD20low malignant cell-lines. Moreover, our approach facilitates the generation of an off-the-shelf TCR library with broad applicability by targeting various HLA alleles. Using the same methodology, we isolated a T-cell clone that efficiently lysed primary HLA-B*07:02pos B-cell malignancies by targeting another CD20-derived peptide. TCR gene transfer of high affinity CD20-specific TCRs can be a valuable addition to current treatment options for patients suffering from CD20low B-cell malignancies.
Concept Learning of Text Documents

Concept learning of text documents can be viewed as the problem of acquiring the definition of a general category of documents. To definite the category of a text document, the Conjunctive of keywords is usually be used. These keywords should be fewer and comprehensible. A naïve method is enumerating all combinations of keywords to extract suitable ones. However, because of the enormous number of keyword combinations, it is impossible to extract the most relevant keywords to describe the categories of documents by enumerating all possible combinations of keywords. Many heuristic methods are proposed, such as GA-base, immune based algorithm. In this work, we introduce pruning power technique and propose a robust enumeration-based concept learning algorithm. Experimental results show that the rules produce by our approach has more comprehensible and simplicity than by other methods.