Miracle-dz/UniFAR-FTUs huggingface dataset:
Resveratrol attenuates 1,2‐dimethylhydrazine (DMH) induced glycoconjugate abnormalities during various stages of colon carcinogenesis

Although a myriad of health promoting effects has been attributed to resveratrol (Res) (3,5,4′‐trihydroxy‐trans‐stilbene), a phytoalexin, the most interesting is its anticancer property. The aim of this work was to elucidate the effectiveness of Res against cellular transformation (glycoconjugate alterations) initiated by 1,2‐dimethylhydrazine (DMH), a colon specific carcinogen. Group 1 were control rats, group 2 were control rats that received Res (8 mg/kg body weight orally every day), rats in groups 3–6 were treated weekly with DMH (20 mg/kg body weight, subcutaneously × 15 times). In addition, groups 4–6 received Res (as in group 2) in three dietary regimens: initiation (I), post‐initiation (PI) and entire period (EP). At the end of the 30 week experimental period in DMH alone exposed rats, altered levels of glycoconjugates (total hexoses, fucose, hexosamine and sialic acid) were observed in liver, intestine and colon tissues. Of the three dietary regimens of Res, the entire period supplementation significantly (p < 0.01) modulated the levels of glycoconjugates and reduced the incidence of adenoma and adenocarcinoma. These findings suggest that Res may extend its chemopreventive effect by restoring the alteration in glycoconjugates that are thought to be involved in the colonic malignant transformation process in this experimental model. Copyright © 2009 John Wiley & Sons, Ltd.
The theoretical basis for the determination of optical pathlengths in tissue: temporal and frequency analysis

A concise theoretical treatment is developed for the calculation of mean time, differential pathlength, phase shift, modulation depth and integrated intensity of measurements of light intensity as a function of time on the surface of tissue, resulting from either the input of picosecond light pulses, or radio frequency-modulated light. The treatment uses the Green's function of the diffusion approximation to the radiative transfer equation, and develops this and its Fourier transform in a variety of geometries. Detailed comparisons are made of several of these parameters in several geometries, and their relation to experimentally measured clinical data. The limitations of the use of phase measurements is discussed.
European Clinical Laboratory, Molecular and Pathological (ECMP) criteria for prefibrotic JAK2V617F-Thrombocythemia and Polycythemia Vera versus MPL515- and CALR-Thrombocythemia and Myelofibrosis: From Dameshek to Michiels 1950-2018

The broad spectrum of heterozygous versus homozygous JAK2 V617F mutated MPN consists ET, ET with early features of PV (prodromal PV), classical PV, masked PV, advanced PV and post-PV myelofi brosis. Combined use of bone marrow histology and increased erythrocyte counts above 5.8x10 12 /L can replace increased red cell mass at time of presentation as the pathognomonic clue for the correct diagnosis of hetero/homozygous or homozygous mutated PV. Erythrocyte counts are in the normal range below 5.8x10 12 /L in heterozygous JAK2 V617F mutated ET and prodromal PV but above 5.8x10 12 /L in heterozygous-homozygous or homozygous mutated PV. The bone marrow cellularity and morphology in pre-fi brotic ET, prodromal PV and PV carrying the JAK2 V617F mutation are overlapping showing clustered increase of large mature pleomorphic megakaryocytes (M) with no increase of cellularity (<60%) in ET. The bone marrow is hypercellular (60%-80%) due to increased erythropoiesis megakaryopoiesis (EM) in prodromal and classical PV and trilinear hypercellular (80%-100% due increased megakaryopoiesis, erythropoiesis and granulopoiesis (EMG) in advanced PV and masked PV. Bone marrow cellularity ranging from normal (<60%) in ET to increased erythropoiesis (EM) in prodromal PV to hypercellular (80-100%) in advanced PV and masked PV largely depends on increasing JAK2 V617F mutation load from low to high on top of other biological MPN variables like constitutional symptoms during long-term follow-up. MPL 515 mutated ET is featured by an increase of clustered small and giant megakaryocytes with hyper-lobulated staghorn-like nuclei in a normal cellular bone marrow. The third entity of pronounced JAK2/MPL wild type ET associated with primary megakaryocytic granulocytic myeloproliferation (PMGM) without PV features proved to be caused by calreticulin (CALR) mutation. CALR mutated thrombocythemia is characterized by dual proliferation of megakaryocytic and granulocytic bone marrow proliferation of dense clustered large to giant immature dysmorphic megakaryocytes with bulky (bulbous) hyperchromatic nuclei, which are not seen in MPL 515 -mutated Thrombocythemia and JAK2 V617F -Thrombocythemia, prodromal PV and classical PV.
Appendix F GROUND-PENETRATING RADAR ( PAPER II )

Study the remediation process. This must be done before attempting to model the process. It must also be recognized that remediation includes any measures applied to the mined area before sweeping with detection systems. For example, it is sometimes the practice to use heavy rollers in an attempt to detonate some mines before sweeping. This can be effective in preemptively disposing of many mines at relatively low cost and risk, but the aftermath can be detrimental to the function of detecting sensors if some unexploded mines are inadvertently buried to greater depths, misoriented, or tilted so that they become hazardous to probe manually, or if their soil context is changed in ways that may affect certain sensors, such as radar, acoustics, or infrared. Any attempt to draw conclusions about enhanced remediation on the basis of modeling must first ascertain that the model’s assumptions are realistic.
Combined analog-digital simulation

The inherent limitations of the analog computer and the digital computer when each is used exclusively give rise to the need for combined analog-digital techniques. The analog computer, which is ideally suited for dynamic calculations, is at a distinct disadvantage where logical decisions are required, or where demands on accuracy and resolution are stringent. In contrast, digital calculations maintain the required accuracy but can be very time consuming. This is a particular burden when many runs are needed for a statistical analysis of a system.
Miniaturized Protein Microarray with Internal Calibration as Point-of-Care Device for Diagnosis of Neonatal Sepsis

Neonatal sepsis is still a leading cause of death among newborns. Therefore a protein-microarray for point-of-care testing that simultaneously quantifies the sepsis associated serum proteins IL-6, IL-8, IL-10, TNF alpha, S-100, PCT, E-Selectin, CRP and Neopterin has been developed. The chip works with only a 4 μL patient serum sample and hence minimizes excessive blood withdrawal from newborns. The 4 μL patient samples are diluted with 36 μL assay buffer and distributed to four slides for repetitive measurements. Streptavidin coated magnetic particles that act as distinct stirring detection components are added, not only to stir the sample, but also to detect antibody antigen binding events. We demonstrate that the test is complete within 2.5 h using a single step assay. S-100 conjugated to BSA is spotted in increasing concentrations to create an internal calibration. The presented low volume protein-chip fulfills the requirements of point-of-care testing for accurate and repeatable (CV < 14%) quantification of serum proteins for the diagnosis of neonatal sepsis.
3D bioprinting technology for regenerative medicine applications

Alternative strategies that overcome existing organ transplantation methods are of increasing importance be-cause of ongoing demands and lack of adequate organ donors. Recent improvements in tissue engineering techniques offer improved solutions to this problem and will influence engineering and medicinal applications. Tissue engineering employs the synergy of cells, growth factors and scaffolds besides others with the aim to mimic the native extracellular matrix for tissue regeneration. Three-dimensional (3D) bioprinting has been explored to create organs for transplanta-tion, medical implants, prosthetics, in vitro models and 3D tissue models for drug testing. In addition, it is emerging as a powerful technology to provide patients with severe disease conditions with personalized treatments. Challenges in tis-sue engineering include the development of 3D scaffolds that closely resemble native tissues. In this review, existing printing methods such as extrusion-based, robotic dispensing, cellular inkjet, laser-assisted printing and integrated tissue organ printing (ITOP) are examined. Also, natural and synthetic polymers and their blends as well as peptides that are exploited as bioinks are discussed with emphasis on regenerative medicine applications. Furthermore, applications of 3D bioprinting in regenerative medicine, evolving strategies and future perspectives are summarized.
A fast centralized computation routing algorithm for self-configuring NoC systems

As technology evolves, networks-on-chip will need to survive to manufacturing faults in order to sustain yield. An effective configuration strategy implies the design of an efficient routing infrastructure, that enables a fast and efficient configuration of the NoC system to go around faulty links and switches. The strategy must minimize the overhead in resources and guarantee the entire system to be deadlock free. A centralized approach, through a monitoring controller is appealing as will get global network visibility. This paper proposes a centralized routing configuration strategy that meets the requirements by means of a fast configuration algorithm for the most common failure patterns. The strategy is designed towards the goals of reduced configuration time and high coverage support (maximum number of supported failure patterns). No extra resources (virtual channels) are needed for the effective final configuration of the system. Results show the effectiveness of the proposed configuration algorithm.
Assessment of cost/benefit of interfaces evaluation techniques

Literature presents a considerable number of techniques that may be used in the process of evaluation of interfaces. Each technique has its own features, involves the employment of different resources, and allows the obtainment of distinct results depending on the way it is conducted. The present article aims at assessing, by means of a set of experiments, the costs and benefits found specifically in the application of three techniques: heuristic evaluation, user tests, and recommendation conformity inspection.
LEF closed-loop scheduling policy for real-time control systems

Today there is a significant body of results of resource management in real-time systems. However, most of them are based on "open-loop" strategies and techniques that do not take into account application demands to dynamically adjust their behavior. To overcome this problem by focusing on control applications, we show a novel scheduling technique: large error first (LEF). This scheduling algorithm uses feedback information from each controlled plant by the application in order to assign computing resources to control tasks. The LEF is used in simulation. By comparing the performance of LEF versus classical open-loop scheduling techniques, encouraging simulation results have been obtained. There are still many issues to be addressed with regard to LEF algorithm. This paper also shows these issues, with possible approaches that should be investigated further
Drug resistance and BCR‐ABL kinase domain mutations in Philadelphia chromosome–positive acute lymphoblastic leukemia from the imatinib to the second‐generation tyrosine kinase inhibitor era: The main changes are in the type of mutations, but not in the frequency of mutation involvement

Patients with Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL) frequently relapse on imatinib with acquisition of BCR‐ABL kinase domain (KD) mutations. To analyze the changes that second‐generation tyrosine kinase inhibitors (TKIs) have brought in mutation frequency and type, a database review was undertaken of the results of all the BCR‐ABL KD mutation analyses performed in the authors' laboratory from January 2004 to January 2013.
Differential Expression of CYC2 Genes and the Elaboration of Floral Morphologies in Hiptage, an Old World Genus of Malpighiaceae

Premise of research. The primarily Neotropical Malpighiaceae exhibit an elegant suite of floral morphological characteristics associated with a specialized mutualism with oil bee pollinators, including bilaterally symmetrical flowers and paired oil glands on the calyx. One clade within the family, Hiptage Gaertn. , has migrated to the paleotropics and lost its association with oil bees. Corresponding to this transition, some members of Hiptage have evolved a highly elaborate zygomorphic corolla with strongly reflexed petals and striking dorsoventral heteranthery. Previously, we demonstrated that expression of CYCLOIDEA2-like (CYC2-like) genes is correlated with the evolution of floral symmetry in Malpighiaceae. Here, we examine CYC2 expression in relation to the evolution of elaborate floral zygomorphy in Hiptage benghalensis. Methodology. CYC2-like genes were cloned from H. benghalensis. The spatial pattern of CYC2 expression was examined with quantitative reverse-transcription PCR on the dissected floral organs. Pivotal results. While most Neotropical Malpighiaceae express two CYC2-like genes, CYC2A and CYC2B, we demonstrate that H. benghalensis has experienced further duplications yielding four copies, which are expressed in all four whorls of the flower. As in Neotropical Malpighiaceae, CYC2A homologs HbCYC2A-1 and HbCYC2A-2 are expressed broadly in the dorsal region of the flower, but unlike that in other Neotropical species, expression also extends to the dorsal stamens. The CYC2B copies HbCYC2B-1 and HbCYC2B-2 are intensely expressed in the single dorsal petal (as in Neotropical Malpighiaceae), but their expression is further detected in the other floral whorls, especially in the stamens of the dorsal region. Conclusions. The relaxation of the conserved expression of CYC2-like genes in Neotropical Malpighiaceae and the expansion to broader floral regions, including the dorsal androecium, correlate with the development of dorsoventral heteranthery in H. benghalensis. We propose that changes in the pattern of CYC2 expression may have contributed to the elaborated androecium of H. benghalensis, which was crucial for its adaptation to a novel pollination strategy.
EFL TEACHERS’ PERCEPTIONS ON ICT USE FOR CONTINUING PROFESSIONAL DEVELOPMENT

Continuing professional development is imperative. However, teachers are often constrained by the lack of availability of time and financial support in joining formal face-to-face professional development program. The development of technology such as ICT provides solutions to create a new learning environment for the teachers to continue their professional development. This study was intended to investigate how EFL teachers’ perceive ICT for continuing professional development, which domain competency that the teachers typically develop through the use of ICT and which ICT tools that teachers mostly used during continuing their professional development. This study employed qualitative approach with a case study design. The participant involved were 16 EFL teachers from five different schools in West Java. The data were collected by using questionnaires and interviews. This study used five dependent variables proposed by Richards & Farrell (2005) in order to describe the component of ICT and of professional development itself. The result showed that teachers do use ICT as a media to continue professional development. The study also revealed that teachers mainly use ITC tools to improve their understanding about the subject matter and also pedagogical knowledge of the subject. As the recommendation it is expected that teachers could maintain and regulate their commitment on continuing professional development.
Modeling implicates inhibitory network bistability as an underpinning of seizure initiation

A plethora of recent experimental literature implicates the abrupt, synchronous activation of GABAergic interneurons in driving the sudden change in brain activity that heralds seizure initiation. However, the mechanisms predisposing an inhibitory network toward sudden coherence specifically during ictogenesis remain unknown. We address this question by comparing simulated inhibitory networks containing control interneurons and networks containing hyper-excitable interneurons modeled to mimic treatment with 4-Aminopyridine (4-AP), an agent commonly used to model seizures in vivo and in vitro. Our in silico study demonstrates that model inhibitory networks with 4-AP interneurons are more prone than their control counterparts to exist in a bistable state in which asynchronously firing networks can abruptly transition into synchrony due to a brief perturbation. We further show that perturbations driving this transition could reasonably arise in vivo based on models of background excitatory synaptic activity in the cortex. Thus, these results propose a mechanism by which an inhibitory network can transition from incoherent to coherent dynamics in a fashion that may precipitate seizure as a downstream effect. Moreover, this mechanism specifically explains why inhibitory networks containing hyper-excitable interneurons are more vulnerable to this state change, and how such networks can undergo this transition without a permanent change in the drive to the system. This, in turn, potentially explains such networks’ increased vulnerability to seizure initiated by GABAergic activity. Author summary For decades, the study of epilepsy has focused on the hypothesis that over-excitation or dis-inhibition of pyramidal neurons underlies the transition from normal brain activity to seizure. However, a variety of recent experimental findings have implicated a sudden synchronous burst of activity amongst inhibitory interneurons in driving this transition. Given the counter-intuitive nature of these findings and the correspondingly novel hypothesis of seizure generation, the articulation of a feasible mechanism of action underlying this dynamic is of paramount importance for this theory’s viability. Here, we use computational techniques, particularly the concept of bistability in the context of dynamical systems, to propose a mechanism for the necessary first step in such a process: the sudden synchronization of a network of inhibitory interneurons. This is the first detailed proposal of a computational mechanism explaining any aspect of this hypothesis of which we are aware. By articulating a mechanism that not only underlies this transition, but does so in a fashion explaining why ictogenic networks might be more prone to this behavior, we provide critical support for this novel hypothesis of seizure generation and potential insight into the larger question of why individuals with epilepsy are particularly vulnerable to seizure.
Two Consecutive Successful Pregnancy Outcomes in a woman with Eisenmenger’s Syndrome: A Case Report

Eisenmenger’s syndrome is a very rare condition in pregnant women. The incidence of ES is about 3% of the pregnant patients with congenital heart defects; however, it can be accompanied with high incidence of maternal and neonatal morbidity and mortality. Therefore, these patients should have efficient contraception or termination of pregnancy in the first trimester. We present two poorly-controlled consecutive pregnancies with good outcomes in a woman with ES to clarify the appropriate function of teamwork in the management of emergency situations in similar cases. Alongside teamwork, good prenatal care is also important because it can result in elective termination in higher gestational age of pregnancy. A 21-year old woman, Repeat II cesarean belonging to a very low socioeconomic class, with ES was admitted to the emergency ward of Imam Hossein teaching hospital affiliated to Shahid Beheshti University of Medical Sciences with labor pain and severe dyspnea in 28 weeks of pregnancy. Echocardiography indicated a PAP of 120 mmHg. The patient had supportive treatment in intensive care unit until she was discharged. Despite previous reports of poor pregnancy outcomes in women with ES, high quality and significant treatment through labor and postpartum period lead to good outcomes in both mother and neonate.
B-type natriuretic peptide is not a volume marker among patients on hemodialysis.

BACKGROUND Although the cardiac biomarker B-type natriuretic peptide (BNP) is strongly related to mortality in end-stage renal disease (ESRD), whether it is a predictor of weight change or blood pressure (BP) response upon probing dry weight among hypertensive hemodialysis patients remains unknown. The purpose of this study was to examine among people with hypertension on hemodialysis whether BNP is a biomarker of excess volume. METHODS Hypertensive hemodialysis patients (n = 150) were randomized to a control group (n = 50) or an ultrafiltration group (n = 100) and followed up for 30 dialysis treatments. After a baseline run-in of six treatments, those assigned to the ultrafiltration group had dry weight probed over 8 weeks. Forty-four-hour interdialytic ambulatory BP and predialysis BNP were measured at the end of run-in period, at 4 weeks and at 8 weeks. RESULTS The median BNP concentration was 93 pg/mL (interquartile range 31-257 pg/mL). The magnitude of decline in the BNP depended on the baseline concentration of BNP, but did not require probing dry weight or weight loss. No relationship existed between decline in postdialysis weight upon probing dry weight and baseline BNP. Furthermore, reduction in the BNP was not required for decline in postdialysis weight. Predialysis log BNP modestly predicted ambulatory systolic and pulse pressure independently of other risk factors. No relationship was found between decline in BP upon probing dry weight and baseline BNP. Upon probing dry weight, reduction in BNP was not required for decline in systolic ambulatory BP. CONCLUSION Taken together, these data suggest that among hypertensive patients on hemodialysis BNP is not a volume marker.
TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast

Target of rapamycin complex 1 (TORC1) is implicated in growth control and aging from yeast to humans. Fission yeast is emerging as a popular model organism to study TOR signaling, although rapamycin has been thought to not affect cell growth in this organism. Here, we analyzed the effects of rapamycin and caffeine, singly and combined, on multiple cellular processes in fission yeast. The two drugs led to diverse and specific phenotypes that depended on TORC1 inhibition, including prolonged chronological lifespan, inhibition of global translation, inhibition of cell growth and division, and reprograming of global gene expression mimicking nitrogen starvation. Rapamycin and caffeine differentially affected these various TORC1‐dependent processes. Combined drug treatment augmented most phenotypes and effectively blocked cell growth. Rapamycin showed a much more subtle effect on global translation than did caffeine, while both drugs were effective in prolonging chronological lifespan. Rapamycin and caffeine did not affect the lifespan via the pH of the growth media. Rapamycin prolonged the lifespan of nongrowing cells only when applied during the growth phase but not when applied after cells had stopped proliferation. The doses of rapamycin and caffeine strongly correlated with growth inhibition and with lifespan extension. This comprehensive analysis will inform future studies into TORC1 function and cellular aging in fission yeast and beyond.