Miracle-dz/UniFAR-FTUs huggingface dataset:
Original Value and Survival Dilemma of Immaterial Cultural Tour Resources in Huizhou Area

The authors define the concept of immaterial cultural tour resources first. It means that cultural existence, in the form of immaterial,which benefits offspring, has potential economic value and can be tour products. Then the authors elaborate that cultural tour resources play the role of original value in Huizhou cultural tour development. Huizhou immaterial culture is one of Chinese traditional elite culture types. Folklore, one of Huizhou immaterial culture forms, is "the living fossil" of Chinese traditional social life. Immaterial culture is the soul of Huizhou cultural tour products and decides the length of life cycle of Huizhou cultural tour products. Based on these ideas and the reality of Huizhou cultural tour resources development, the four dilemmas of the original immaterial cultural resources are presented: the bad tour environment, the natural environment and social-cultural space that immaterial culture depends on to survive are decayed and destroyed; the crisis of cultural identification in which local people gradually lose their interests in the local culture and in their deep thoughts there is a kind of feeling of lost cultural personality and dignity as well; inadequate rules or regulations that there are no systemic rules or regulations to protect the original culture in the aspects of economy, society and the governmental behavior; the delay of study and findings in the fact that the field of the study of Huizhou culture is narrow and lack of multi-discipline participation particularly and the applied study is seriously inefficient. In the final place, the authors try to propose some strategies about Huizhou immaterial cultural tour resources development: ladder-like development, general layout and systemic development; setting rules and regulations according to the law to strengthen management and protection; decommercialization, controling the scale of commerce in the main tourist sites; fostering the sense of community to guide local people to participate in the tour development.
Decreased Susceptibility to Tigecycline Mediated by a Mutation in mlaA in Escherichia coli Strains

a mutation in mlaA 2 Fang He , Juan Xu , Jianfeng Wang, Qiong Chen, Xiaoting Hua, Ying Fu, 3 Yunsong Yu 4 5 1 Department of Infectious Diseases, Sir Run Run Shaw Hospital, School of Medicine, 6 Zhejiang University, Hangzhou, Zhejiang 310016, China. 7 2 Institute of Hygiene, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang 8 310013, China. 9 3 Department of Respiratory Diseases, The Affiliated Hospital of Hangzhou Normal 10 University, Hangzhou, Zhejiang 310015, China. 11 4 Department of Clinical Laboratory, Hangzhou First People’s Hospital, Hangzhou, 12 Zhejiang 310006, China. 13 5 Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, 14 Zhejiang University, Hangzhou, Zhejiang 310016, China. 15 16 17 † These authors contributed equally to this study. 18 19 * Corresponding author: 20 Prof. Yunsong Yu; 21 Tel: +86-571-8600-6142; 22 Fax: +86-571-8600-6142; 23 E-mail: yvys119@163.com. 24 25 Running title: mlaA mutation contributes to tigecycline resistance. 26 27
A Single-Machine Two-Agent Scheduling Problem by GA Approach

A single-machine two-agent scheduling problem with a truncation learning effect is being addressed in the study. The truncation learning effect means that the actual processing time of a job is a function of the sum of processing times of already scheduled jobs and a control parameter. The aim is to find an optimal schedule to minimize the total weighted completion time of jobs of the first agent under the circumstances that no tardy job is allowed for the second agent. A branch-and-bound and three heuristic-based genetic algorithms (GAs) are proposed to solve the problem. Also presented in the study are the computational results of all proposed algorithms.
Effect of Bifidobacteriuminfantis on Interferon- γ- Induced Keratinocyte Apoptosis: A Potential Therapeutic Approach to Skin Immune Abnormalities

Current management of atopic dermatitis is mainly directed to the reduction of cutaneous inflammation. Since patients with atopic dermatitis show abnormalities in immunoregulation, a therapy aimed to adjust their immune function could represent an alternative approach, particularly in the severe form of the disease. Indeed, T-lymphocytes constitute a large population of cellular infiltrate in atopic/allergic inflammation and a dysregulated T-cell induced keratinocyte apoptosis appears to be an important pathogenetic factor of the eczematous disease. In recent years, attention has been focused on the interaction between host and probiotics which may have anti-inflammatory properties and immunomodulatory activities. The aim of the present work is to investigate the effect of a selected probiotic extract, the Bifidobacterium infantis extract, on a human keratinocyte cell line (HaCaT) abnormal apoptosis induced by activated-T-lymphocyte. An in vitro model of atopic dermatitis was used to assess the ability of the probiotic extract to protect HaCaT from apoptosis induced by soluble factors (IFN-γ and CD95 ligand) released by human T-lymphocytes in vitro activated with anti-CD3/CD28 mAbs or Phytohemoagglutinin. Evidence is given that the bacterial extract treatment was able to totally prevent T lymphocyte-induced HaCaT cell apoptosis in vitro. The mechanism underlying this inhibitory effect has been suggested to depend on the ability of the bacterial extract to significantly reduce anti-CD3/CD28 mAbs and mitogen-induced T-cell proliferation, IFN-γ generation and CD95 ligand release. These preliminary results may represent an experimental basis for a potential therapeutic approach mainly targeting the skin disorders-associated immune abnormalities.
Cost analysis in construction projects using fuzzy OLAP cubes

In this paper a fuzzy multidimensional structure to analyze cost data in construction projects is proposed. As we will see, the use of a fuzzy structure provides a more intuitive use of the information associated to construction domain. This way, primary evaluation criteria in assessing the success of construction projects like economic objectives can be more friendly controlled. We propose both a fuzzy cost multidimensional structure and its implementation in Linguistic F-Cube Factory, a fuzzy OLAP system.
Field Dependence of Critical Current of  $\text{YBa}_{2}\text{Cu}_{3}\text{O}_{7-\delta}$ Film in Low Magnetic Field

The dependence of magnetic moment relaxation of YBa2Cu3O7-δ films on magnetic field was studied in both partly and fully penetrated critical states. A simple approach was used to account for the influence of the demagnetizing effect on the measured moment. Field and current dependence of the activation energy for flux motion U was calculated from macroscopic electrodynamics. Field dependence of the critical current density Jc was obtained from the analysis of U. It was shown that the critical current is suppressed by field and that the suppression takes place even in partly penetrated critical state. The observed behavior contradicts the field independence of Jc expected in low fields for single vortex pinning in the collective pinning model.
Multi-model soft switching tracking control and robust least-squares weighted control allocation for near space interceptor

This paper deals with the multi-model soft switching tracking control (MMSSTC) design problem with a disturbance observer and a new robust least-squares weighted control allocation (RLSWCA) method for the near space interceptor (NSI) with aerodynamic fins and reaction jets. Initially, the flight envelop of the NSI is divided into some small subregions by the fuzzy partition method, a slow-fast loop soft switching model is constructed to represent the NSI system based on the local Takagi-Sugeno (T-S) model, and a disturbance observer is proposed to estimate the unknown disturbance. Then, based on the descriptor system method, a MMSSTC is developed to not only ensure the stability of the closed-loop NSI system, but also achieve a specified control performance. Furthermore, a new RLSWCA algorithm is employed to distribute the virtual control command among the redundant actuators. The purpose of this algorithm is to find the optimal control vector of the actuators by minimizing the worse-case residual, while taking into account of the uncertainty in the control effectiveness matrix and the actuator constraints. Finally, simulation results on the NSI demonstrate the effectiveness of the proposed control scheme.
Olmesartan medoxomil reverses left ventricle hypertrophy and reduces inflammatory cytokine IL-6 in the renovascular hypertensive rats.

AIM To investigate the effects of Olmesartan Medoxomil (OM) on left ventricle hypertrophy (LVH) and inflammatory cytokines IL-6 and IL-10 levels in renovascular hypertensive rats. MATERIALS AND METHODS Qualified 30 male Wistar rats were randomly divided into three groups: sham-operation group (SO, n=10), model control group (MC, n=10), and Olmesartan Medoxomil group (OM, n=10). Renovascular hypertension was induced by ligating the abdominal aorta and 10 mg/kg OM was administered daily to the OM group by gastric perfusion for 7 weeks. The ratio of left ventricle mass to body weight (LVM/BW) was calculated as the index of cardiac hypertrophy, and the inflammatory cytokines IL-6 and IL-10 in serum and cardiac tissue were measured by ELISA assays. RESULTS The LVM/BW ratios in the MC group were about 50% higher than that in the SO group (p < 0.001). The OM group showed much reduced LVM/BW ratios compared with the MC group (p < 0.001) and were similar to that in the SO group (p > 0.05), indicating a complete reversal of the left ventricular hypertrophy caused by aorta ligation. The IL-6 and IL-10 levels in both the serum and cardiac tissue increased following aorta ligation (MC vs. SO, p < 0.001). While OM treatment significantly reduced IL-6 levels in the aorta-ligated rats (OM vs. MC, p < 0.001), IL-10 levels were not affected (OM vs. MC, p > 0.05). CONCLUSIONS OM completely reversed left ventricle hypertrophy and reduced IL-6 levels in renovascular hypertensive rats. Its effect on IL-10 levels in this animal model was not statistically significant.
Numerical Experiments on Hedging Cliquet Options

In this paper, we conduct pricing and hedging experiments in order to check whether simple stochastic volatility models are capable of capturing forward volatility and forward skew risks correctly. As a reference, we use the Bergomi model, which treats these risks accurately. The results of our experiments show that the cost of poor volatility modeling in the Heston model, the Barndorff-Nielsen–Shephard model and a variance-gamma model with stochastic arrival is too high when pricing and hedging cliquet options.
Global pinning synchronization of switched complex networks

Global pinning synchronization in complex networks has been extensively studied in the last decades due to its potential applications. One common assumption in most of the existing literature within this context is that the underlying network structure of the augmented network with pinning links is static. This paper aims to provide some simple yet efficient criteria for ensuring global pinning synchronization in complex directed networks with a time-varying network structure. The analytical results are derived by using a combined tool from M-matrix method and stability analysis of switched systems. It is theoretically shown that the global pinning synchronization in switched complex networks can be ensured if the augmented network contains a directed spanning tree frequently enough and some suitable conditions are satisfied. The effectiveness of the analytical analysis is verified by some numerical simulations.
Compulsive features in behavioural addictions: the case of pathological gambling.

AIMS To describe, in the context of DSM-V, how a focus on addiction and compulsion is emerging in the consideration of pathological gambling (PG). METHODS A systematic literature review of evidence for the proposed re-classification of PG as an addiction. RESULTS Findings include: (i) phenomenological models of addiction highlighting a motivational shift from impulsivity to compulsivity associated with a protracted withdrawal syndrome and blurring of the ego-syntonic/ego-dystonic dichotomy; (ii) common neurotransmitter (dopamine, serotonin) contributions to PG and substance use disorders (SUDs); (iii) neuroimaging support for shared neurocircuitries between 'behavioural' and substance addictions and differences between obsessive-compulsive disorder (OCD), impulse control disorders (ICDs) and SUDs; (iv) genetic findings more closely related to endophenotypic constructs such as compulsivity and impulsivity than to psychiatric disorders; (v) psychological measures such as harm avoidance identifying a closer association between SUDs and PG than with OCD; (vi) community and pharmacotherapeutic trials data supporting a closer association between SUDs and PG than with OCD. Adapted behavioural therapies, such as exposure therapy, appear applicable to OCD, PG or SUDs, suggesting some commonalities across disorders. CONCLUSIONS PG shares more similarities with SUDs than with OCD. Similar to the investigation of impulsivity, studies of compulsivity hold promising insights concerning the course, differential diagnosis and treatment of PG, SUDs, and OCD.
Identification of a Gene Cluster for the Formation of Extracellular Polysaccharide Precursors in the Chemolithoautotroph Acidithiobacillus ferrooxidans

ABSTRACT A cluster of five genes, proposed to be involved in the formation of extracellular polysaccharide (EPS) precursors via the Leloir pathway, have been identified in the acidophilic autotroph Acidithiobacillus ferrooxidans. The order of the genes is luxA-galE-galK-pgm-galM, encoding a LuxA-like protein, UDP-glucose 4-epimerase, galactokinase, phosphoglucomutase, and galactose mutarotase, respectively. The gal cluster forms a single transcriptional unit and is therefore an operon. Two other putative genes of the Leloir pathway, galU, potentially encoding UDP-glucose pyrophosphorylase, and a gene designated galT-like, which may encode a galactose-1-phosphate uridylyltransferase-like activity, were found unlinked in the genome. Using semiquantitative reverse transcription-PCR, the genes of the gal operon were shown to be expressed more during growth in iron medium than in growth in sulfur medium. The functions of galE, pgm, galU, and the galT-like gene were validated by complementation of Escherichia coli mutants and by in vitro enzyme assays. The data suggest that A. ferrooxidans is capable of synthesizing the EPS precursors UDP-glucose and UDP-galactose. In addition, genes rfbA, -B, -C, and -D were identified in the genome of A. ferrooxidans, suggesting that it can also synthesize the EPS precursor dTDP-rhamnose. Since EPSs constitute the major bulk of biofilms, this study may provide an initial model for the metabolic pathways involved in biofilm formation in A. ferrooxidans and aid in understanding the role of biofilms in mineral leaching and the formation of acid mine drainage.
Improving Execution Time of Parallel Programs on Large Scale Chip Multiprocessors with Constant Average Power Processing

In this paper we propose a microarchitectural technique called Constant Average Power Processing (CAPP) that reduces the execution time of parallel programs by dynamically detecting the power slack at runtime and directing it to specific core(s) that are the bottleneck at any given time. The key insight of this work is that by sensing the current, communicating it to the global controller and adjusting the cores' frequencies, it is possible to maintain a constant power level in a distributed and scalable manner. We evaluate the potential benefits and scalability of the proposed technique on a set of synthetic benchmarks and compare the results with related work such as Running Average Power Limit (RAPL).
Evolving organizational relationships in the era of accountability : a case study of a senior leadership group in a lower secondary school in Greater Manchester

5 Acknowledgements 6 List of tables and figures 7 1.0 Introduction 8 1.1 Why accountabilty and evolving organizational relationships? 8 1.2 Research question and problem 9 1.3 Outline of thesis 10 2.0 Theoretical framework 11 2.1 Brief outline of theoretical concepts 11 2.2 Weberian Bureaucracy, New Public Management and Networks 11 2.2.1 Bureaucracy according to Weber 11 2.2.2 New Public Management 13 2.2.3 Post New Public Management: Rediscovering Bureaucracy or Networks 14 2.2.4 Governance in networks according to Kjaer 15 2.3 Accountability 17 2.3.1 School effectiveness and school improvement 17 2.3.2 Accountability and responsibility 18 2.3. 3 Defining accountability: according to Sinclair 20 2.3. 4 Internal and external accountability 21 2.3. 5 Professional and hierarchical accountability 21 2.3. 6 Accountability and governance: according to Burke 22 2.4 Distributed leadership 23 2.5 Leadership practice and accountability in Middletown College 26 3.0 Case study: Middletown College 27 3.1 General description of Middletown College 27 3.2 Organizational structure 27
FDTD Formulation for Graphene Modeling Based on Piecewise Linear Recursive Convolution and Thin Material Sheets Techniques

A finite-difference time-domain formulation based on piecewise linear recursive convolution method and on thin material sheets technique is developed for modeling terahertz graphene antennas and some other photonic components. The graphene sheets are modeled by specific recursive equations obtained for tangential electric field components, allowing one to easily apply voltage or current sources between the sheets. The effective conductivity of graphene sheets in Yee's three-dimensional lattice is calculated and used in simulations. A bow-tie-like geometry is investigated, aiming at resonance tuning. The developed numerical formulation is validated by comparison of results to data published in literature.
Article Commentary: The X-gal Caution in Neural Transplantation Studies

Cell transplantation into host brain requires a reliable cell marker to trace lineage and location of grafted cells in host tissue. The lacZ gene encodes the bacterial (E. coli) enzyme β-galactosidase (β-gal) and is commonly visualized as a blue intracellular precipitate following its incubation with a substrate, “X-gal,” in an oxidation reaction. LacZ is the “reporter gene” most commonly employed to follow gene expression in neural tissue or to track the fate of transplanted exogenous cells. If the reaction is not performed carefully—with adequate optimization and individualization of various parameters (e.g., pH, concentration of reagents, addition of chelators, composition of fixatives) and the establishment of various controls—then misleading nonspecific background X-gal positivity can result, leading to the misidentification of cells. Some of this background results from endogenous nonbacterial β-gal activity in discrete populations of neurons in the mammalian brain; some results from an excessive oxidation reaction. Surprisingly, few articles have emphasized how to recognize and to eliminate these potential confounding artifacts in order to maximize the utility and credibility of this histochemical technique as a cell marker. We briefly review the phenomenon in general, discuss a specific case that illustrates how an insufficiently scrutinized X-gal positivity can be a pitfall in cell transplantation studies, and then provide recommendations for optimizing the specificity and reliability of this histochemical reaction for discerning E. coli β-gal activity.
Wave-front curvature as a cause of slow conduction and block in isolated cardiac muscle.

We have investigated the role of wave-front curvature on propagation by following the wave front that was diffracted through a narrow isthmus created in a two-dimensional ionic model (Luo-Rudy) of ventricular muscle and in a thin (0.5-mm) sheet of sheep ventricular epicardial muscle. The electrical activity in the experimental preparations was imaged by using a high-resolution video camera that monitored the changes in fluorescence of the potentiometric dye di-4-ANEPPS on the surface of the tissue. Isthmuses were created both parallel and perpendicular to the fiber orientation. In both numerical and biological experiments, when a planar wave front reached the isthmus, it was diffracted to an elliptical wave front whose pronounced curvature was very similar to that of a wave front initiated by point stimulation. In addition, the velocity of propagation was reduced in relation to that of the original planar wave. Furthermore, as shown by the numerical results, wave-front curvature changed as a function of the distance from the isthmus. Such changes in local curvature were accompanied by corresponding changes in velocity of propagation. In the model, the critical isthmus width was 200 microns for longitudinal propagation and 600 microns for transverse propagation of a single planar wave initiated proximal to the isthmus. In the experiments, propagation depended on the width of the isthmus for a fixed stimulation frequency. Propagation through an isthmus of fixed width was rate dependent both along and across fibers. Thus, the critical isthmus width for propagation was estimated in both directions for different frequencies of stimulation. In the longitudinal direction, for cycle lengths between 200 and 500 milliseconds, the critical width was < 1 mm; for 150 milliseconds, it was estimated to be between 1.3 and 2 mm; and for the maximum frequency of stimulation (117 +/- 15 milliseconds), it was > 2.5 mm. In the transverse direction, critical width was between 1.78 and 2.32 mm for a basic cycle length of 200 milliseconds. It increased to values between 2.46 and 3.53 mm for a basic cycle length of 150 milliseconds. The overall results demonstrate that the curvature of the wave front plays an important role in propagation in two-dimensional cardiac muscle and that changes in curvature may cause slow conduction or block.
Game Analysis of Mechanisms Safeguarding against Opportunism in Learning Alliances

The value creation and governance mechanisms safeguarding against opportunistic behavior are studied separately in most literature on learning alliances.By the method of dynamic game,this paper finds that there exists a type of self-(enforcing) governance mechanism inherent in the value creation activities,which is characteristically based on the role of the commitments contained in the relationship among the complementarity of the partners' resources and two types of learning capacities,and by which the potential opportunistic behavior of alliance partners can be effectively safeguarded against,and thus the coincidence of the value creation and safeguards against opportunistic behavior can be realized.
Molecular cloning of the penicillin G acylase gene from Arthrobacter viscosus

Penicillin G acylase was purified from the cultured filtrate of Arthrobacter viscosus 8895GU and was found to consist of two distinct subunits with apparent molecular weights of 24,000 (alpha) and 60,000 (beta). The partial N-terminal amino acid sequences of the alpha and beta subunits were determined with a protein gas phase sequencer, and a 29-base oligonucleotide corresponding to the partial amino acid sequence of the alpha subunit was synthesized. An Escherichia coli transformant having the penicillin G acylase gene was isolated from an A. viscosus gene library by hybridization with the 29-base probe. The resulting positive clone was further screened by the Serratia marcescens overlay technique. E. coli carrying a plasmid designated pHYM-1 was found to produce penicillin G acylase in the cells. This plasmid had an 8.0-kilobase pair DNA fragment inserted in the EcoRI site of pACYC184.