Miracle-dz/UniFAR-FTUs huggingface dataset:
Cellular compartmentation of zinc in leaves of the hyperaccumulator thlaspi caerulescens

Cellular compartmentation of Zn in the leaves of the hyperaccumulator Thlaspi caerulescens was investigated using energy-dispersive x-ray microanalysis and single-cell sap extraction. Energy-dispersive x-ray microanalysis of frozen, hydrated leaf tissues showed greatly enhanced Zn accumulation in the epidermis compared with the mesophyll cells. The relative Zn concentration in the epidermal cells correlated linearly with cell length in both young and mature leaves, suggesting that vacuolation of epidermal cells may promote the preferential Zn accumulation. The results from single-cell sap sampling showed that the Zn concentrations in the epidermal vacuolar sap were 5 to 6.5 times higher than those in the mesophyll sap and reached an average of 385 mM in plants with 20,000 &mgr;g Zn g-1 dry weight of shoots. Even when the growth medium contained no elevated Zn, preferential Zn accumulation in the epidermal vacuoles was still evident. The concentrations of K, Cl, P, and Ca in the epidermal sap generally decreased with increasing Zn. There was no evidence of association of Zn with either P or S. The present study demonstrates that Zn is sequestered in a soluble form predominantly in the epidermal vacuoles in T. caerulescens leaves and that mesophyll cells are able to tolerate up to at least 60 mM Zn in their sap.
Watermarking Digital Artworks

paper presents a digital watermarking scheme based on a new application of DWT and SVD for color artworks protection. This scheme uses the major features of the two chrominance components where the watermark bits are embedded only into one chrominance component according to the color prevalence rate. In watermark embedding process, more modifications can be done upon the selected chrominance component, while more readable information is needed during the watermark extraction process. Simulation results demonstrate that the proposed scheme yields a high level of robustness against various image processing operations without sacrificing the visual quality of watermarked artwork image.
Survey on a muilt-keyword ranked based search and privacy preservation of distributed documents in the network

In Information Networks, owner can store their data over dispersed numerous servers. It encouraging clients to store and get to their information in and from various servers by settling down anyplace and on any gadget. It is an extremely difficult to give efficient inquiry on appropriated reports additionally give the security on proprietor's data. The current framework gives one conceivable arrangement that is protection safeguarding ordering (PPI). In this framework, archives are disseminated over different private servers which are by and large controlled by cloud/open server. At the point when client needs a few archives, they inquiry to open cloud, which then returns the applicant list that is private server rundown to clients. In the wake of getting rundown, client can look the archives on particular private server however in this framework; data are put away in plain content structure on private server that is security is traded off. In any case, proposed framework improves this current framework to make it more secure and proficient. Initially reports are put away in scrambled structure on the private servers and after that utilization Key Distribution Center (KDC) for permitting unscrambling of information get from private server, at customer side. The proposed framework likewise actualizes TF-IDF, which gives the positioning of results to clients.
Interaction between DNA Gyrase and Quinolones: Effects of Alanine Mutations at GyrA Subunit Residues Ser83and Asp87

ABSTRACT DNA gyrase is a target of quinolone antibacterial agents, but the molecular details of the quinolone-gyrase interaction are not clear. Quinolone resistance mutations frequently occur at residues Ser83 and Asp87 of the gyrase A subunit, suggesting that these residues are involved in drug binding. Single and double alanine substitutions were created at these positions (Ala83, Ala87, and Ala83Ala87), and the mutant proteins were assessed for DNA supercoiling, DNA cleavage, and resistance to a number of quinolone drugs. The Ala83 mutant was fully active in supercoiling, whereas the Ala87 and the double mutant were 2.5- and 4- to 5-fold less active, respectively; this loss in activity may be partly due to an increased affinity of these mutant proteins for DNA. Supercoiling inhibition and cleavage assays revealed that the double mutant has a high level of resistance to certain quinolones while the mutants with single alanine substitutions show low-level resistance. Using a drug-binding assay we demonstrated that the double-mutant enzyme-DNA complex has a lower affinity for ciprofloxacin than the wild-type complex. Based on the pattern of resistance to a series of quinolones, an interaction between the C-8 group of the quinolone and the double-mutant gyrase in the region of residues 83 and 87 is proposed.
A Graph Grammar to Transform DAGs into Graphs Describing Multithreaded Programs

The scheduling of tasks in a parallel program is an NP-complete problem, where scheduling tasks over multiple processing units requires an effective strategy to maximize the exploitation of the parallel hardware. Several studies focus on the scheduling of parallel programs described into DAGs (Directed Acyclic Graphs). However, this representation does not describe a multithreaded program suitably. This paper shows the structure and semantics of a DCG, an abstraction which describes a multithreaded program, and proposes standards to map structures found in DAGs into segments of a DCG. A graph grammar has been developed to perform the proposed transformation and case studies, using DAG found in the literature, validate the transformation process.
Performance Optimization of CP-PLL for SoC Applications

Phase locked loops (PLLs) are integral parts of communication devices used in various applications such as frequency synthesizer, clock recovery circuits, synchronization for digital communications, carrier phase, frequency tracking, etc. The non-ideal effects in PLL such as jitter, phase noise, reference spurs, phase error, etc. influence the PLL performance which significantly affects the overall system. For example, a 10% performance degradation of PLL leads to approximately 20% performance degradation of frequency synthesizers. In conventional CMOS charge pump circuit, phase error is caused due to leakage current, timing mismatch and current mismatch. The phase error due to current mismatch is more significant as compared to phase error due to timing mismatch and leakage current. Thus, in this work, two charge pump circuits with minimum area are designed in Matlab Simulink environment to reduce current mismatch. The designed charge pump using basic current mirror is compared with the ideal current mirror. Simulated results show that current mismatch and phase error for basic current mirror are approximately 12.19 % and 0.3480 rad. respectively. This set up can be easily utilized to design various charge pump to achieve minimum current mismatch for SoC applications.
Airway Hyperresponsiveness and Quality of Life in Western Red Cedar Asthmatics Removed from Exposure

Objectives Most western red cedar asthmatics (WRCA) continue to have symptoms even after removal from exposure. Consequently, health-related quality of life (HRQL) is often impaired. The objective of this study was to evaluate the relationship between two measures of AHR and HRQL scores in those with WRCA. Methods HRQL was determined by the short form 36 (SF-36) in 46 male, non-smoking individuals with WRCA removed from exposure to western red cedar, on average, 15 years earlier. The relationships between the SF-36 total score and its eight domains with 2 indices from methacholine-stimulated airway hyperresponsiveness (the provocative concentration of methacholine causing a 20% fall in FEV1 [PC20] and bronchial reactivity index [BRI]) were analyzed by the Pearson correlation and multiple linear regression. Results PC20 was significantly correlated with the SF-36 total score and its two domains of bodily pain and general health (r = 0.34, 0.40, 0.40, p = 0.023, 0.006, 0.006, respectively). BRI was significantly correlated with bodily pain and general health (r = −0.35, −0.42, p = 0.017, 0.004, respectively); correlations remain significant after adjusting for age, ethnicity, years since diagnosis, years since last exposure and use of inhaled corticosteroid. BRI and other measures of airway responsiveness were not associated with inhaled corticosteroids use. Conclusions In Western red cedar asthmatics removed from exposure, measures of airway responsiveness are associated with HRQL.
Exploratory and Hierarchical Factor Analysis of the WJ-IV Cognitive at School Age

Exploratory and confirmatory factor analytic studies were not reported in the Technical Manual for the Woodcock-Johnson, 4th ed. Cognitive (WJ IV Cognitive; Schrank, McGrew, & Mather, 2014b) Instead, the internal structure of the WJ IV Cognitive was extrapolated from analyses based on the full WJ IV test battery (Schrank, McGrew, & Mather, 2014b). Even if the veracity of extrapolating from the WJ IV full battery were accepted, there were shortcomings in the choices of analyses used and only limited information regarding those analyses was presented in the WJ IV Technical Manual (McGrew, Laforte, & Shrank, 2014). The present study examined the structure of the WJ IV Cognitive using exploratory factor analysis procedures (principal axis factoring with oblique [promax] rotation followed by application of the Schmid–Leiman, 1957, procedure) applied to standardization sample correlation matrices for 2 school age groups (ages 9–13; 14–19). Four factors emerged for both the 9–13 and 14–19 age groups in contrast to the publisher’s proposed 7 factors. Results of these analyses indicated a robust manifestation of general intelligence (g) that exceeded the variance attributed to the lower-order factors. Model-based reliability estimates supported interpretation of the higher-order factor (i.e., g). Additional analyses were conducted by forcing extraction of the 7 theoretically posited factors; however, the resulting solution was only partially aligned (i.e., Gs, Gwm) with the theoretical structure promoted in the Technical Manual and suggested the preeminence of the higher-order factor. Results challenge the hypothesized structure of the WJ IV Cognitive and raise concerns about its alignment with Cattell-Horn-Carroll theory.
An all-digital Sigma-Delta-frequency discriminator of arbitrary order

In this paper, we propose all-digital frequency synthesizer architecture, based on an all-digital /spl Sigma//spl Delta/-frequency discriminator. The new all-digital synthesizer is compared to previously published work. The architecture of the /spl Sigma//spl Delta/-frequency discriminator is verified using behavioral simulation.
Hybrid static-dynamic attacks against software protection mechanisms

Advances in reverse engineering and program analyses have made software extremely vulnerable to malicious host attacks. These attacks typically take the form of intellectual property violations, against which the software needs to be protected. The intellectual property that needs to be protected can take on different forms. The software might, e.g., consist itself of proprietary algorithms and datastructures or it could provide controlled access to copyrighted material. Therefore, in recent years, a number of techniques have been explored to protect software. Many of these techniques provide a reasonable level of security against static-only attacks. Many of them however fail to address the problem of dynamic or hybrid static-dynamic attacks. While this type of attack is already commonly used by black-hats, this is one of the first scientific papers to discuss the potential of these attacks through which an attacker can analyze, control and modify a program extensively. The concepts are illustrated through a case study of a recently proposed algorithm for software watermarking [6].
Genome-Wide Diet-Gene Interaction Analyses for Risk of Colorectal Cancer

Dietary factors, including meat, fruits, vegetables and fiber, are associated with colorectal cancer; however, there is limited information as to whether these dietary factors interact with genetic variants to modify risk of colorectal cancer. We tested interactions between these dietary factors and approximately 2.7 million genetic variants for colorectal cancer risk among 9,287 cases and 9,117 controls from ten studies. We used logistic regression to investigate multiplicative gene-diet interactions, as well as our recently developed Cocktail method that involves a screening step based on marginal associations and gene-diet correlations and a testing step for multiplicative interactions, while correcting for multiple testing using weighted hypothesis testing. Per quartile increment in the intake of red and processed meat were associated with statistically significant increased risks of colorectal cancer and vegetable, fruit and fiber intake with lower risks. From the case-control analysis, we detected a significant interaction between rs4143094 (10p14/near GATA3) and processed meat consumption (OR = 1.17; p = 8.7E-09), which was consistently observed across studies (p heterogeneity = 0.78). The risk of colorectal cancer associated with processed meat was increased among individuals with the rs4143094-TG and -TT genotypes (OR = 1.20 and OR = 1.39, respectively) and null among those with the GG genotype (OR = 1.03). Our results identify a novel gene-diet interaction with processed meat for colorectal cancer, highlighting that diet may modify the effect of genetic variants on disease risk, which may have important implications for prevention.
Speaker diarization using normalized cross likelihood ratio

In this paper, we present the Normalized Cross Likelihood Ratio (NCLR) and the advantages of using it in a speaker diarization system. First, the NCLR is used as a dissimilarity measure between two Gaussian speaker models in the speaker change detection step and its contribution to the performance of speaker change detection is compared with those of BIC and Hostelling's T2-Statistic measures. Then, the NCLR measure is modified to deal with multi-gaussian adapted models in the cluster recombination step. This step ends the step-by-step speaker diarization process after the BIC-based hierarchical clustering and the Viterbi re-segmentation steps. By comparing the NCLR measure with the CLR (Cross Likelihood Ratio) one, more than 30% of relative diarization error is reduced in ESTER evaluation data.
Ynot: dependent types for imperative programs

We describe an axiomatic extension to the Coq proof assistant, that supports writing, reasoning about, and extracting higher-order, dependently-typed programs with side-effects. Coq already includes a powerful functional language that supports dependent types, but that language is limited to pure, total functions. The key contribution of our extension, which we call Ynot, is the added support for computations that may have effects such as non-termination, accessing a mutable store, and throwing/catching exceptions. The axioms of Ynot form a small trusted computing base which has been formally justified in our previous work on Hoare Type Theory (HTT). We show how these axioms can be combined with the powerful type and abstraction mechanisms of Coq to build higher-level reasoning mechanisms which in turn can be used to build realistic, verified software components. To substantiate this claim, we describe here a representative series of modules that implement imperative finite maps, including support for a higher-order (effectful) iterator. The implementations range from simple (e.g., association lists) to complex (e.g., hash tables) but share a common interface which abstracts the implementation details and ensures that the modules properly implement the finite map abstraction.
Novel cross-talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses

The insulin-like growth factor-I receptor (IGF-IR), plays a key role in regulating mammalian development and growth, and is frequently deregulated in cancer contributing to tumor initiation and progression. Discoidin domain receptor 1 (DDR1), a collagen receptor tyrosine-kinase, is as well frequently overexpressed in cancer and implicated in cancer progression. Thus, we investigated whether a functional cross-talk between the IGF-IR and DDR1 exists and plays any role in cancer progression. Using human breast cancer cells we found that DDR1 constitutively associated with the IGF-IR. However, this interaction was enhanced by IGF-I stimulation, which promoted rapid DDR1 tyrosine-phosphorylation and co-internalization with the IGF-IR. Significantly, DDR1 was critical for IGF-IR endocytosis and trafficking into early endosomes, IGF-IR protein expression and IGF-I intracellular signaling and biological effects, including cell proliferation, migration and colony formation. These biological responses were inhibited by DDR1 silencing and enhanced by DDR1 overexpression. Experiments in mouse fibroblasts co-transfected with the human IGF-IR and DDR1 gave similar results and indicated that, in the absence of IGF-IR, collagen-dependent phosphorylation of DDR1 is impaired. These results demonstrate a critical role of DDR1 in the regulation of IGF-IR action, and identify DDR1 as a novel important target for breast cancers that overexpress IGF-IR.
Mass segregation in young star clusters: can it be detected from the integrated properties?

We consider the effect of mass segregation on the observable integrated properties of star clusters. The measurable properties depend on a combination of the dynamical age of the cluster and the physical age of the stars in the cluster. To investigate all possible combinations of these two quantities we propose an analytical model for the mass function of segregated star clusters that agrees with the results of N-body simulations, in which any combination can be specified. For a realistic degree of mass segregation and a fixed density profile we find with increasing age an increase in the measured core radii and a central surface brightness that decreases in all filters more rapidly than what is expected from stellar evolution alone. Within a Gyr the measured core radius increases by a factor of two and the central surface density in all filters of a segregated cluster will be overestimated by a similar factor when not taking into account mass segregation in the conversion from light to mass. We find that the $V-I$ colour of mass segregated clusters decreases with radius by about 0.1-0.2 mag, which could be observable. From recent observations of partially resolved extra-galactic clusters a decreasing half-light radius with increasing wavelength was observed, which was attributed to mass segregation. These observations can not be reproduced by our models. We find that the differences between measured radii in different filters are always smaller than 5%.
Productivity and Characteristics of Firms: An application of a bootstrapped data envelopment analysis to Japanese firm-level data

This paper examines the relationships between productivity growth and characteristics of firms using Japanese firm-level data during the period 1995-2004. Applying a bootstrapped Malmquist index approach and weighted least squares (WLS) to two retail trade industries, we estimate the firm-level productivity growth rates and the effects of firms' characteristics on those growth rates. In addition, decomposing productivity growth into technical efficiency change and technical progress, we discuss mechanisms of productivity growth in detail. Our estimation reveals that productivity growth of department stores and supermarkets was stagnant during the sample period. It also indicates that positive technical efficiency changes are usually offset by technical regress and vice versa. Furthermore, effects of firms' characteristics on both productivity components are sometimes conflicting as well. In view of these findings, industrial policies should be carefully devised, based upon their efficiency distribution.
Development of a DNA-analytical Method for the Identification of Animal Hair Fibers in Textiles

During the last several years, the demand of animal natural fibers for the production of high-quality textiles has increased worldwide, especially in Europe, Japan and North America. Due to the restricted availability and the high prices, adulteration and false declaration are common. Usually, fiber analysis is done by scanning electron microscopy, but this method is very time-consuming and expensive, and results strongly depend on processing stage and expertise of the microscopist. For these reasons, reliable methods are required to determine the composition and the proportion of distinct animal fibers in yarns, fabrics and garments, irrespective of their processing conditions. In this study, a DNA-analytical method is presented to unequivocally identify cashmere/cashgora, fine wool, yak and camel hair (Bactrian camel, dromedary) in untreated and treated (washed, bleached, dyed) fibers samples, as well as in fiber blends.
The relationship between helicobacter pylori infection and gastro-esophageal reflux disease

Background: Gastro-esophageal reflux disease is a common condition, affecting 25%-40% of the population. Increasing attention has been paid to the relationship between Helicobacter pylori infection and reflux esophagitis. Aim: The aim of this study was to investigate the association between CagA+ H. pylori and endoscopically proven gastro-esophageal reflux disease. Patients and Methods: The study group included 60 hospital patients with gastro-esophageal reflux disease between 2007 and 2009 as compared with 30 healthy patients from a control group that was age and sex matched. Helicobacter pylori CagA+ was identified by an immunological test (Immunochromatography test) (ACON, USA). Results: Helicobacter pylori CagA+ was present in 42/60 (70%) of the patients with gastro-esophageal reflux disease and in 11/30 (36.6%) patients in the control group (p=0.002). The Odds ratio = 0.8004 with 95% Confidence Interval = from 0.3188 to 2.0094. The relative risk=1.35 that indicates an association between Helicobacter pylori and disease. Conclusions: The presence of Helicobacter pylori is significantly increased in patients with gastro-esophageal reflux disease as compared with the control group.
(E)-4-[(1-Benzyl-4-benzylidene-2,5-dioxopyrrolidin-3-yl)methyl]benzaldehyde 0.25-hydrate

The crystal structure of the title compound, C26H21NO3·0.25H2O, reveals one stereogenic centre in the molecule. Nevertheless, due to the observed centrosymmetric space group, both enantiomers are present in the crystal packing. The water molecule of crystallisation is located on a crystallographic inversion center. The molecule contains one five-membered ring (A) and three six-membered rings (benzyl ring B, benzylidene ring C and formylbenzyl ring D). All four rings are not coplanar: the dihedral angles between rings A and B, A and C, and A and D are 70.35 (9), 33.8 (1) and 60.30 (9)°, respectively. In the crystal, pairs of weak C—H⋯O interactions lead to the formation of centrosymmetric dimers. Additional C—H⋯O interactions link the dimers into chains along [011].