Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluating patient experience in online health communities: Implications for health care organizations

Background: Online communities that focus on health-related matters have rapidly increased in number in the last several years or so. The increasing demand from health consumers for such forums have led several leading health care organizations (HCOs), including Kaiser Permanente and Johns Hopkins, to establish online communities/discussion forums as part of their patient-support services. Patients' interactions in such HCO-led online health communities potentially add another important dimension to the overall patient experience. However, there has been limited research focus on measuring or evaluating patients' experience in such online health communities. Purposes: The objective of this study was to evaluate patients' online community experience (OCE) and examine its impact on patients' attitude toward the HCO and its services. Method: The data collection was conducted using an online questionnaire sent to consumers/patients who participated in the online health communities of three large academic medical centers: the Johns Hopkins Pathology discussion board, run by the pathology department at Johns Hopkins University; the MD Anderson Cancer survivor board, run by MD Anderson Cancer Center at the University of Texas; and the Joslin Discussion Board, run by Joslin Diabetes Center affiliated with Harvard Medical School. Confirmatory factor analysis was done to validate the four dimensions of OCE. Linear regression technique was used to validate the impact of OCE on patient attitudes. Findings: The results provide support for four dimensions of patients' OCE: pragmatic, empathic, sociability, and usability. Furthermore, all these four dimensions of OCE had a positive impact on patient's attitudes toward the HCO and its services. Practice Implications: An understanding of the four dimensions of patient experience in online health communities and its implications on patient attitudes could help HCOs to design, deploy, and manage such online health communities more effectively.
Finite-Length Repeat-Accumulate Codes on the Binary Erasure Channel

This paper considers the finite-length performance of repeat-accumulate codes on the binary erasure channel. We provide lower bounds for the minimum stopping set size of RA codes and develop finite-length analysis algorithms for them. Using these results the effect of the RA accumulator and the choice of repetition rate on the decoding performance of finite length RA codes is investigated, and their performance compared to that of low-density parity-check codes
Phosphoproteomics by mass spectrometry: insights, implications, applications and limitations

Phosphorylation of proteins is a predominant, reversible post-translational modification. It is central to a wide variety of physiological responses and signaling mechanisms. Recent advances have allowed the global scope of phosphorylation to be addressed by mass spectrometry using phosphoproteomic approaches. In this perspective, we discuss four aspects of phosphoproteomics: the insights and implications from recently published phosphoproteomic studies and the applications and limitations of current phosphoproteomic strategies. Since approximately 50,000 known phosphorylation sites do not yet have any ascribed function, we present our perspectives on a major function of protein phosphorylation that may be of predictive value in hypothesis-based investigations. Finally, we discuss strategies to measure the stoichiometry of phosphorylation in a proteome-wide manner that is not provided by current phosphoproteomic approaches.
Audio transients modeling by damped & delayed sinusoids (DDS)

In this paper, we present a novel parametric model based on an important evolution of McAulay & Quatieri sinusoidal models [5]. This model takes into account a damping factor as well as a delay parameter which makes it more efficient for modeling strong audio transients such as castanets onsets without pre-echo effects'. We also develop an original algorithm to estimate the model parameters by means of a high resolution method followed by a sub-band analysis.
Automated extraction of information on protein-protein interactions from the biological literature

MOTIVATION To understand biological process, we must clarify how proteins interact with each other. However, since information about protein-protein interactions still exists primarily in the scientific literature, it is not accessible in a computer-readable format. Efficient processing of large amounts of interactions therefore needs an intelligent information extraction method. Our aim is to develop an efficient method for extracting information on protein-protein interaction from scientific literature. RESULTS We present a method for extracting information on protein-protein interactions from the scientific literature. This method, which employs only a protein name dictionary, surface clues on word patterns and simple part-of-speech rules, achieved high recall and precision rates for yeast (recall = 86.8% and precision = 94.3%) and Escherichia coli (recall = 82.5% and precision = 93.5%). The result of extraction suggests that our method should be applicable to any species for which a protein name dictionary is constructed. AVAILABILITY The program is available on request from the authors.
The China Patient-Centered Evaluative Assessment of Cardiac Events (China PEACE) Retrospective Study of Acute Myocardial Infarction: Study Design

Background— Cardiovascular diseases are rising as a cause of death and disability in China. To improve outcomes for patients with these conditions, the Chinese government, academic researchers, clinicians, and >200 hospitals have created China Patient-Centered Evaluative Assessment of Cardiac Events (China PEACE), a national network for research and performance improvement. The first study from China PEACE, the Retrospective Study of Acute Myocardial Infarction (China PEACE-Retrospective AMI Study), is designed to promote improvements in acute myocardial infarction (AMI) quality of care by generating knowledge about the characteristics, treatments, and outcomes of patients hospitalized with AMI across a representative sample of Chinese hospitals during the past decade. Methods and Results— The China PEACE-Retrospective AMI Study will examine >18 000 patient records from 162 hospitals identified using a 2-stage cluster sampling design within economic–geographic regions. Records were chosen from 2001, 2006, and 2011 to identify temporal trends. Data quality will be monitored by a central coordinating center and will, in particular, address case ascertainment, data abstraction, and data management. Analyses will examine patient characteristics, diagnostic testing patterns, in-hospital treatments, in-hospital outcomes, and variation in results by time and site of care. In addition to publications, data will be shared with participating hospitals and the Chinese government to develop strategies to promote quality improvement. Conclusions— The China PEACE-Retrospective AMI Study is the first to leverage the China PEACE platform to better understand AMI across representative sites of care and during the past decade in China. The China PEACE collaboration among government, academicians, clinicians, and hospitals is poised to translate research about trends and patterns of AMI practices and outcomes into improved care for patients. Clinical Trial Registration— URL: http://www.clinicaltrials. gov. Unique identifier: NCT01624883.
Association of Bax and Bak Homo-oligomers in Mitochondria

ATP depletion induced by hypoxia or mitochondrial inhibitors results in Bax translocation from cytosol to mitochondria and release of cytochrome c from mitochondria into cytosol in cultured rat proximal tubule cells. Translocated Bax undergoes further conformational changes to oligomerize into high molecular weight complexes (Mikhailov, V., Mikhailova, M., Pulkrabek, D. J., Dong, Z., Venkatachalam, M. A., and Saikumar, P. (2001) J. Biol. Chem. 276, 18361–18374). Here we report that following Bax translocation in ATP-depleted rat proximal tubule cells, Bak, a proapoptotic molecule that normally resides in mitochondria, also reorganizes to form homo-oligomers. Oligomerization of both Bax and Bak occurred independently of Bid cleavage and/or translocation. Western blots of chemically cross-linked membrane extracts showed nonoverlapping “ladders” of Bax and Bak complexes in multiples of ∼21 and ∼23 kDa, respectively, consistent with molecular homogeneity within each ladder. This indicated that Bax and Bak complexes were homo-oligomeric. Nevertheless, each oligomer could be co-immunoprecipitated with the other, suggesting a degree of affinity between Bax and Bak that permitted co-precipitation but not cross-linking. Furthermore, dissociation of cross-linked complexes by SDS and renaturation prior to immunoprecipitation did not prevent reassociation of the two oligomeric species. Notably, expression of Bcl-2 prevented not only the oligomerization of Bax and Bak, but also the association between these two proteins in energy-deprived cells. Using Bax-deficient HCT116 and BMK cells, we show that there is stringent Bax requirement for Bak homo-oligomerization and for cytochrome c release during energy deprivation. Using Bak-deficient BMK cells we further show that Bak deficiency is associated with delayed kinetics of Bax translocation but does not affect either the oligomerization of translocated Bax or the leakage of cytochrome c. These results suggest a degree of functional cooperation between Bax and Bak in this form of cell injury, but also demonstrate an absolute requirement of Bax for mitochondrial permeabilization.
Lightweight Security and Privacy-Preserving Scheme for V2G Connection

Vehicle-to-grid (V2G) connection allows electricity exchange between electric vehicles (EVs) and grid, i.e., EVs are used as temporary storage for extra generated power. However, V2G connections suffer from certain security threats, such as EV's privacy and authenticating it to grid. In this paper, we propose a lightweight secure and privacy-preserving V2G connection scheme, in which the power grid assures the confidentiality and integrity of exchanged information during (dis)charging electricity sessions and overcomes EVs' authentication problem. The proposed scheme guarantees the financial profits of the grid and prevents EVs from acting maliciously. Meanwhile, EVs preserve their private information by generating their own pseudonym identities. In addition, the scheme keeps the accountability for the electricity-exchange trade. The simulation results show that the proposed scheme significantly reduces the total communication and computation load for V2G connection especially for EVs.
Heterogeneity of V2‐derived interneurons in the adult mouse spinal cord

Spinal neurons and networks that generate rhythmic locomotor activity remain incompletely defined, prompting the use of molecular biological strategies to label populations of neurons in the postnatal mouse. During spinal cord development, expression of Lhx3 in the absence of Isl1 specifies a V2 interneuronal fate. In this study, postnatal V2‐derived interneurons were identified by yellow fluorescent protein (YFP) expression in the double‐transgenic offspring of Lhx3Cre/+ × thy1‐loxP‐stop‐loxP‐YFP mice. While some motoneurons were labelled, several populations of interneurons predominantly located in lamina VII could also be distinguished. Small interneurons were located throughout the spinal cord whereas larger interneurons were concentrated in the lumbar enlargement. Some V2‐derived interneurons were propriospinal, with axons that bifurcated in the lateral funiculus. V2‐derived interneurons gave rise to populations of both excitatory and inhibitory interneurons in approximately equal proportions, as demonstrated by in situ hybridization with VGLUT2 mRNA. Immunohistochemical studies revealed YFP+ boutons throughout the spinal cord. Both glutamatergic and glycinergic YFP+ boutons were observed in lamina IX where many apposed motoneuron somata. GABAergic YFP+ boutons were also observed in lamina IX, and they did not form P‐boutons. At P0, more than half of the YFP+ interneurons expressed Chx10 and thus were derived from the V2a subclass. In adult mice, there was an increase in Fos expression in V2‐derived interneurons following locomotion, indicating that these neurons are active during this behaviour. The heterogeneity of V2‐derived interneurons in adult mice indicates that physiologically distinct subpopulations, including last‐order interneurons, arise from these embryonically defined neurons.
Blood glucose and hormonal responses to small and large meals in healthy young and older women.

Blood glucose regulation in the fasting and fed states has important implications for health. In addition, the ability to maintain normal blood glucose homeostasis may be an important determinant of an individual's capacity to regulate food intake. We tested the hypothesis that aging is associated with an impairment in the ability to maintain normal blood glucose homeostasis following the consumption of large meals but not small ones, a factor that could help to explain age-related impairments in the control of food intake and energy regulation. The subjects were eight healthy younger women (25 +/- 2 years, SD) and eight healthy older women (72 +/- 2 years) with normal body weight and glucose tolerance. Following a 36-h period when diet and physical activity were controlled, subjects consumed test meals containing 0, 1046, 2092, and 4184 kJ (simulating extended fasting, and consumption of a snack, a small meal, and a moderately large meal), with 35% of energy from fat, 48% from carbohydrate, and 17% from protein. Each subject consumed each of the test meals on a separate occasion. Serial blood samples were collected at baseline and during 5 h after consumption of the meals. Measurements were made of circulating glucose, insulin, glucagon, free fatty acids, and triglycerides. There was no significant difference between young and older women in their hormone and metabolite responses to fasting and consumption of the 1046-kJ meal. However, following consumption of 2092 and 4148 kJ, older individuals showed exaggerated responses and a delayed return to premeal values for glucose (p = .023), insulin (p = .010), triglycerides (p = .023), and the ratio of insulin to glucagon (p = .026). In conclusion, these results suggest an impairment in the hormonal and metabolite responses to large meals in older women.
Understanding the Challenges of Improving Sanitation and Hygiene Outcomes in a Community Based Intervention: A Cross-Sectional Study in Rural Tanzania

Good sanitation and clean water are basic human rights yet they remain elusive to many rural communities in Sub-Saharan Africa (SSA). We carried out a cross sectional study to examine the impact of a four-year intervention aimed at improving access to water and sanitation and reducing waterborne disease, especially diarrhea in children under five years old. The study was carried out in April and May 2015 in Busangi, Chela and Ntobo wards of Kahama District of Tanzania. The interventions included education campaigns and improved water supply, and sanitation. The percentage of households (HHs) with access to water within 30 min increased from 19.2 to 48.9 and 17.6 to 27.3 in the wet and dry seasons, respectively. The percentage of HHs with hand washing facilities at the latrine increased from 0% to 13.2%. However, the incidence of diarrhea among children under five years increased over the intervention period, RR 2.91 95% CI 2.71–3.11, p < 0.0001. Availability of water alone may not influence the incidence of waterborne diseases. Factors such as water storage and usage, safe excreta disposal and other hygiene practices are critical for interventions negating the spread of water borne diseases. A model that articulates the extent to which these factors are helpful for such interventions should be explored.
LOCAL ECONOMIC VOTING AND RESIDENCE-BASED REGIONALISM IN SOUTH KOREA: EVIDENCE FROM THE 2007 PRESIDENTIAL ELECTION

Abstract Regional bloc voting in South Korea has been ascribed to voters’ psychological attachments to birthplace. This article seeks to expand the existing discussion of regionalism by showing that economic conditions in voters’ places of residence affect vote choices at the individual level and produce clustering of votes at the aggregate level in South Korea. While the idea of residence-based regionalism has previously been suggested, empirical scrutiny of the idea has been limited. Exploiting a Bayesian multilevel strategy, this article provides evidence that short-term economic changes at the province level affected voters’ choices in the 2007 presidential election in South Korea, independent of the long-term political affiliation between regional parties and their constituents. The positive association between local economic conditions and vote choices remains significant, controlling for perceptions of national economic conditions and other individual level covariates such as age and political attitudes.
Does the Short Rate Revert to its Mean in the Risk-Neutral World?

We propose a methodology to calibrate the non-linear and non-affine short rate models under physical and risk-neutral probability measures, based on the U.S treasury yield curve data. For this purpose, we price the default-free bond using the Markov chain approximation method built on the well-established idea of local consistency. Integrating the standard recursive filtering algorithm and the Markov chain approximation bond price formula, we propose a Markov chain filter in which the transition equation is a general stochastic differential equation for the short rate dynamics, and the measurement equation can be based on observations of any interest rate derivatives. Our simulation experiments show that popular parameter estimators can generate spurious non-linear drift estimates. However, the proposed Markov chain filter does not. In contrast to the existing literature, through our empirical findings we argue that the short rate does not revert to its mean under the risk-neutral probability measure. Our findings corroborate the observations that yields on the short end term structure have remained near 0% for more than 30 months since the implementation of Quantitative Easing monetary policy.
Evolution of limb bone loading and body size in varanid lizards

SUMMARY Geometric scaling predicts that stresses on limb bones and muscles should increase with body size. Mammals counter this size-related increase in stress partially through changes in bone geometry, but largely through changes in posture, with larger species having a more erect stance. However, the ability to counter size-related stresses in this fashion may be limited to those taxa that have a parasagittal gait (such as mammals), where legs are swung underneath the body. We examined locomotor kinematics for 11 species of varanid lizards (from 0.04 to 8 kg body mass) that have a sprawling gait, to determine how they moderate size-related stresses. Posture, as indicated by femur adduction and hip heights, did not change significantly with body size, beyond that expected from geometrical scaling. Instead, lizards mitigated size-related increases in stress by increasing duty factor and possibly reducing femur rotation. Incorporating these factors in biomechanical models predicted that both bending (∝M0.016, where M is mass) and torsional (∝M–0.049) stresses should be nearly independent of body size over the size range examined. However, increasing duty factor and reducing femur rotation probably have deleterious effects on speed, and this difference in kinematics with size may explain why speed scales lower for sprawling lizards than for parasagittal mammals (∝M0.17 and ∝M0.24, respectively). Further, paralleling conclusions for the synapsid lineage, these findings suggest that evolution from sprawling to upright posture did not occur in archosaurs as a response to larger size; rather, these archosaurs likely became upright first and larger later.
[Evaluation of dental plaque by quantitative digital image analysis system].

OBJECTIVE To analyze the plaque staining image by using image analysis software, to verify the maneuverability, practicability and repeatability of this technique, and to evaluate the influence of different plaque stains. METHODS In the study, 30 volunteers were enrolled from the new dental students of Peking University Health Science Center in accordance with the inclusion criteria. The digital images of the anterior teeth were acquired after plaque stained according to filming standardization.The image analysis was performed using Image Pro Plus 7.0, and the Quigley-Hein plaque indexes of the anterior teeth were evaluated. RESULTS The plaque stain area percentage and the corresponding dental plaque index were highly correlated,and the Spearman correlation coefficient was 0.776 (P<0.01). Intraclass correlation coefficients of the tooth area and plaque area which two researchers used the software to calculate were 0.956 and 0.930 (P<0.01). The Bland-Altman analysis chart showed only a few spots outside the 95% consistency boundaries. The different plaque stains image analysis results showed that the difference of the tooth area measurements was not significant, while the difference of the plaque area measurements significant (P<0.01). CONCLUSION This method is easy in operation and control,highly related to the calculated percentage of plaque area and traditional plaque index, and has good reproducibility.The different plaque staining method has little effect on image segmentation results.The sensitive plaque stain for image analysis is suggested.
The Relationship between Oxidative Stress, Inflammation, and Atherosclerosis in Renal Transplant and End-Stage Renal Disease Patients

Objectives: Cardiovascular risk is increased in the early stages of chronic kidney disease (CKD) and is also found to be ongoing in renal transplant (Rtx) patients. As a sign of atherosclerosis, increased carotid intima–media thickness (CIMT) has been widely accepted as a strong predictor of cardiovascular disease (CVD) and mortality in the end-stage renal disease (ESRD) patients. Ischemia-modified albumin (IMA), pentraxin-3 (PTX-3), and neutrophil-to-lymphocyte ratio (NLR) were introduced as oxidative stress and inflammatory biomarkers in ESRD. The role of Rtx in terms of atherogenesis, oxidative stress, and inflammation is still unclear. We aimed to investigate the relationship between IMA, PTX-3, NLR, and CIMT in Rtx patients without overt CVD and to compare these results with those obtained from healthy subjects and ESRD patients receiving hemodialysis (HD) and peritoneal dialysis (PD). Design and methods: Cross-sectional analysis in which CIMT measurements, NLR, and serum PTX-3 and IMA levels were assessed in 18 Rtx patients (10 females; mean age: 40.0 ± 13.3 years), 16 PD patients (7 females; 40.2 ± 12.9 years), 14 HD patients (8 females; 46.6 ± 10.7 years), and 19 healthy subjects (9 females; 36.9 ± 8.9 years). Results: IMA, PTX-3, and high-sensitive C-reactive protein (hs-CRP) levels, NLR, and CIMT of Rtx patients were found to be significantly higher compared with healthy subjects ( p = 0.04, p < 0.0001, p < 0.005, p = 0.005, and p = 0.005, respectively). IMA level was positively correlated with hs-CRP and PTX-3 levels, NLR, and CIMT when all participants were included (r = 0.338, p = 0.005; r = 0.485, p < 0.0001; r = 0.304, p = 0.013; and r = 0.499, p < 0.0001, respectively). Conclusion: There has been ongoing inflammation, oxidative stress, and atherosclerosis in Rtx patients.