Miracle-dz/UniFAR-FTUs huggingface dataset:
Muscle Tension Line Groups Reconstruction in Bilateral Cleft Lip Repair

Background:Bilateral cleft lip is considered to be the most difficult cleft lip to repair. More and more surgeries are concerned about the reconstruction of orbicularis muscle and the pursuit of philtrum shaping in bilateral cleft lip repair, but most have little success. Years of study on the orbicularis muscle of children with cleft lip resulted in authors’ creation of muscle tension line groups theory. Through implementation of this theory, the authors have achieved favorable results in microform cleft lip repair. The authors also applied this concept to bilateral cleft lip repair. Methods:Between January 2010 and December 2014, 31 children with bilateral cleft lip received operations in authors’ department, and underwent muscle tension line group reconstruction in accordance with the theory of muscle tension line groups. Two third-party doctors judged postoperative results using a 3-point visual analogue scale. Results:Twenty-two of the 31 children completed a follow-up 6 months to 1 year after surgery. Most postoperative and follow-up results were satisfactory. Conclusion:Fully reconstructed muscle tension line groups can not only assist with close fractures, but, for example, also help adduct the nasal alar, and elevate the nasal floor. Furthermore, the surgery can be used to reconstruct the 3-dimensional structure of the philtrum. Ultimately, surgical application of the muscle tension line groups theory proved its feasibility and potential for further development.
Etude numérique de la sédimentation d’une vésicule

Les ve sicules re sultent d’une autoorganisation des phospholipides en une bicouche ferme e. Ce syste`me permet de mode liser le comportement me canique de membranes biologiques mais aussi d’interfaces molles de liposomes utilise s dans l’industrie. Nous e tudions ici nume riquement la de formation d’une ve sicule qui se dimente. Ceci constitue un proble`me d’interaction fluide-structure, dans lequel l’interface est fortement de forme e. La me thode des e le ments finis pour la re solution des e quations du mode`le est utilise e, le suivi de l’interface e tant re alise graˆce a` la me thode ALE. L’e tude nume rique montre que les ve sicules peuvent atteindre de multiples formes stationnaires, mais peuvent e galement eˆtre instables, en fonction des parame`tres de l’e tude : syme trie, de gonflement et nombre de Bond.
Molecular systematics and biogeography of the fanged frogs of Southeast Asia.

Our analysis of parts of the mitochondrial ribosomal 12S and 16S genes from 39 populations of Southeast Asian ranid frogs confirms that the fanged frogs are a monophyletic clade. This group, properly called Limnonectes, appears to have arisen in the early Tertiary at a time when free faunal exchange was possible among Southeast Asia, Borneo, Sumatra, Java, and, probably, Sulawesi. Four species groups are tentatively identified within the clade. Part of group 1 includes species related to L. kuhlii that occur in Borneo. Another part of group 1 includes species from Malay Peninsula and Thailand that are related to L. pileata. Species group 2, L. leporina, occurs only in Borneo. Species group 3 is restricted to species distributed in Sulawesi and the Philippines. Species group 4 includes L. blythii and relatives. There is a lack of compatibility between phylogenetic hypotheses generated from molecular and morphological data sets. These differences are related, in large part, to whether some species of Limnonectes have secondarily lost fangs or whether lack of fangs represents the primitive condition.
Validation of numerical model of a liquid flow in a tundish by laboratory measurements

T. Merder, M. Saternus: Silesian University of Technology, Department of Metallurgy, Katowice, Poland M. Warzecha: Czestochowa University of Technology, Department of Metals Extraction and Recirculation, Czestochowa, Poland P. Warzecha: Czestochowa, Poland The article presents results of physical and numerical modelling of steel fl ow through a tundish of continuous casting machine. In numerical calculations the infl uence of mesh density was tested and the correctness of the fl ow description in the near-wall region was checked using Standard Wall Function model. Obtained results were verifi ed using experimental results of velocity fi eld (PIV method) coming from a water tundish model.
A fully reconfigurable low-power floating-gate transistor-capacitor filter

This paper presents a fully reconfigurable low-power filter that is composed of a cascade of floating-gate transistor-capacitor (FGT-C) biquadratic sections suitable for biomedical applications. The proposed FGT-C filter provides both the lowpass and bandpass outputs to the following stage with all filter parameters reconfigurable, including the gains, natural frequency, quality factor, DC levels for input and outputs. The filter topology exhibits good modularity so that the biquadratic sections can be cascaded and scaled up to implement high-order frequency responses easily with efficient area and power consumption. A prototype chip has been fabricated in a 0. 35μm 2P4M CMOS process and each FGT-C biquadratic filter occupies an area of 0.0313mm2. From measurement results, the filter consumes 118.4nW of power with a dynamic range of 45.5dB while operating at 1.8V power supply with a 10kHz bandwidth.
Socioeconomic status differences in recreational physical activity levels and real and perceived access to a supportive physical environment.

BACKGROUND Spatial access to recreational facilities and perceptions of the neighborhood environment and physical activity levels were examined by the socioeconomic status of area of residence (SES). METHODS A cross-sectional survey of adults (18-59 years) (n = 1,803) stratified by SES using a geographic-based index was conducted. RESULTS Respondents in low SES areas had superior spatial access to many recreational facilities, but were less likely to use them compared with those living in high SES areas. They were more likely to perceive that they had access to sidewalks and shops, but also perceived that their neighborhood was busier with traffic, less attractive, and less supportive of walking. After adjustment, respondents living in low SES areas were 36% less likely to undertake vigorous activity. While they were more likely to walk for transport, this was not statistically significant (OR, 1.27; 95% CI, 0.98-1.64), nor were other SES differences in walking for recreation and walking as recommended. Modifiable environmental factors were associated with walking and vigorous activity, especially perceived access to sidewalks and neighborhood attractiveness. Spatial access to attractive, public open space was associated with walking. CONCLUSIONS Creating supportive environments--particularly sidewalks in attractive neighborhoods--has the potential to increase walking and vigorous activity.
The New Historicism and Its Discontents: Politicizing Renaissance Drama

This essay, while referring particularly to commentary about Renaissance drama, examines the new historicism more generally as one of the most powerful and interesting forms of criticism on the contemporary scene. How do new-historicist critics characterize the text? What do they mean by history? How do they understand the relation between the two? And finally, are there other, arguably more useful kinds of answers available to us than the ones the new historicists typically provide?
Biodegradation and microbial community changes upon shrimp shell wastes amended in mangrove river sediment

Chitin, a homopolymer of N-acetyl-D-glucosamine (GlcNAc) residues linked by β 1-4 bonds, is the most abundant renewable natural resource after cellulose. It is widely distributed in nature as the integuments of crustaceans and insects and as a component of fungi and algae. This study investigated the effects of a bifunctional chitinase/lysozyme-producing strain, Pseudomonas aeruginosa K-187, on degradation of shrimp shells and the survival conditions of bacterial strains in mangrove river sediment of Tamsui River. The structures of the whole bacterial community of the samples were measured by using polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) technique. Results show that three bacterial strains (Acrobacter sp., Shewanella sp., and Marinobacterium sp.) which originated from the mangrove river sediment were found predominant in the 6 days-incubation sample of P. aeruginosa K-187 amended mangrove river sediment. Meanwhile, biomass, reducing sugar, and total sugar were found highest in the 6 weeks-incubation sample of shrimp shell powder and P. aeruginosa K-187-amended mangrove river sediment. According to the results, we assumed that the amendment of P. aeruginosa K-187 can enhance the biodegradation of shrimp shells in the seawater containing mangrove river sediment. We hope that these findings may provide some useful information for the reclamation of chitin-containing wastes in our environment.
Current treatment of chronic heart failure in primary care; still room for improvement.

UNLABELLED RATIONAL AND AIMS: In recent years, guidelines for treatment of patients with chronic heart failure (CHF) have been updated. Insight in current pharmacological and non-pharmacological treatment of CHF in primary care, which was non-optimal in earlier studies, is limited. We aim to describe current pharmacological and non-pharmacological treatment of CHF in primary care. METHODS In this cross-sectional observational study, we included a representative sample of 357 patients diagnosed with CHF from 42 primary care practices in the Netherlands. We combined medical record data with data from patient and doctor questionnaires. RESULTS Mean age of patients was 75.7 years (SD 10.2), 53% were male, and 73% of patients had mild heart failure (New York Heart Association class I or II). 76.5% of patients received diuretics. Angiotensin-converting enzyme inhibitors were prescribed in 40.6% and angiotensin-II receptor blockers in 20.7%; beta-blockers were prescribed to 54.6%, while 24.9% received spironolactone. Patients with more severe heart failure had a lower probability of being treated according to guideline recommendations. Relevant lifestyle advice was given to 40-60% of the patients, depending on the specific lifestyle advice. CONCLUSIONS Implementation of evidence-based pharmacotherapy for heart failure in primary care has improved since clinical guidelines have been updated; especially with respect to prescription of beta-blockers. However, there still seems ample room for improvement, as in the case for providing lifestyle advice.
ZnO nanorods for electronic nanodevice applications

We report on fabrications and characteristics of high performance ZnO nanorod nanodevices including Schottky diodes, metal-oxide-semiconductor field-effect transistors (MOSFETs), metal-semiconductor field-effect transistors (MESFETs) and logic gate devices. In particular, after coating polymer thin films on ZnO nanorod surfaces, the nanorod MOSFETs exhibited much improved field effect transistor characteristics including field effect electron mobility as high as 3000 cm2/Vs. In addition, ZnO nanorod Schottky diodes and MESFETs were fabricated using Au/ZnO Schottky contacts without any specific oxide etching process, further resulting in realization of ZnO nanorod logic gates.
IMMUNOTHÉRAPIE ANTITUMORALE PAR TRANSFERT DE L'ARN MESSAGER DE L'ANTIGÈNE MELANA/MART-1

Une reponse antitumorale suite a l'induction de lymphocytes T cytotoxiques peut etre generee apres transfert in vitro ou directement in vivo d'ARNm d'antigenes tumoraux dans les cellules dendritiques (DCs). Cependant, peu de vecteurs permettent une introduction efficace d'ARNm dans les DCs. Nous avons elabore des nanoparticules d'ARNm avec des polymeres cationiques histidyles (polyplexes), des lipides cationiques histidyles (lipoplexes) ou un melange des deux (lipopolyplexes). Ces vecteurs deviennent fusiogenes en milieu acide et favorisent la delivrance de l'ARNm dans le cytosol lors de son endocytose. Une optimisation de l'ARNm en ajoutant en 5' une coiffe 3'-O-methyl-m75'GpppS'G (ARCA) et en 3' une queue de 100 adenosines (A 100) a permis la synthese d'un transcrit ARCA-ARNm-A 100 qui permet une bonne expression de l'antigene dans les DCs. La polyethyleneimine hisidylee a ete identifiee comme etant un bon agent de transfert de l'ARNm de l'antigene du melanome MART-1 dans les DCs matures in vitro. Pour une vaccination par injection directe de l'ARNm codant l'antigene, nous avons developpe de nouvelles nanoparticules tripartites (lipopolyplexes) correspondant a des polyplexes d'ARNm ARCA-MART1-A100 avec un derive PEGyle de la polylysine histidylee encapsules dans des liposomes histidyles. Par injection systemique, ces lipopolyplexes induisent un effet protecteur specifique et significatif contre la progression tumorale cutanee et metastatique pulmonaire du melanome murin B16F10. La mise en place d'une reponse immune de type Thl avec une forte secretion d'IFN-y et une activite T cytotoxique a pu etre mise en evidence montrant ainsi l'interet des lipopolyplexes histidyles.
A survey of routing protocols in Wireless Sensor Networks: Hierarchical routing

Wireless Sensor Networks (WSNs) is the most developing areas in many factors like environment & wildlife monitoring, security & military surveillance, healthcare and many more. Also, routing protocols play a very important part in terms of efficiency in WSNs. Due to limitations of unreliable low power links and resources between the sensor nodes; design of an efficient routing protocol is a difficult problem. This paper has surveyed about Routing Techniques and basically about Hierarchical based routing with its protocols like LEACH, TEEN, PEGASIS, SEP and DEEC. And then finally their comparative study is provided.
Elevated Plus Maze for Mice

Although the mouse genome is now completely sequenced, the functions of most of the genes expressed in the brain are not known. The influence of a given gene on a specific behavior can be determined by behavioral analysis of mutant mice. If a target gene is expressed in the brain, behavioral phenotype of the mutant mice could elucidate the genetic mechanism of normal behaviors. The elevated plus maze test is one of the most widely used tests for measuring anxiety-like behavior. The test is based on the natural aversion of mice for open and elevated areas, as well as on their natural spontaneous exploratory behavior in novel environments. The apparatus consists of open arms and closed arms, crossed in the middle perpendicularly to each other, and a center area. Mice are given access to all of the arms and are allowed to move freely between them. The number of entries into the open arms and the time spent in the open arms are used as indices of open space-induced anxiety in mice. Unfortunately, the procedural differences that exist between laboratories make it difficult to duplicate and compare results among laboratories. Here, we present a detailed movie demonstrating our protocol for the elevated plus maze test. In our laboratory, we have assessed more than 90 strains of mutant mice using the protocol shown in the movie. These data will be disclosed as a part of a public database that we are now constructing. Visualization of the protocol will promote better understanding of the details of the entire experimental procedure, allowing for standardization of the protocols used in different laboratories and comparisons of the behavioral phenotypes of various strains of mutant mice assessed using this test.
Ubiquitin Lys 63 is involved in ubiquitination of a yeast plasma membrane protein Ub / proteasome pathway is involved in the degradation of

Ub/proteasome pathway is involved in the degradation of J.-M.Galan and R.Haguenauer-Tsapis1 abnormal proteins, and regulatory proteins with short halfInstitut Jacques Monod CNRS-UMRC9922 Université Paris VII, lives (Hochstrasser, 1996b). 2 place Jussieu, 75251 Paris, Cedex 05, France It has long been known that ubiquitination does more 1Corresponding author than simply signal degradation by the proteasome. Histone e-mail: haguenauer@ijm.jussieu. fr H2A is a stable protein, despite being conjugated to Ub
Distinct regulatory mechanisms control integrin adhesive processes during tissue morphogenesis

Cell adhesion must be precisely regulated to enable both dynamic morphogenetic processes and the subsequent transition to stable tissue maintenance. Integrins link the intracellular cytoskeleton and extracellular matrix, relaying bidirectional signals across the plasma membrane. In vitro studies have demonstrated that multiple mechanisms control integrin‐mediated adhesion; however, their roles during development are poorly understood. We used mutations that activate or deactivate specific functions of vertebrate β‐integrins in vitro to investigate how perturbing Drosophila βPS‐integrin regulation in developing embryos regulation affects tissue morphogenesis and maintenance. We found that morphogenetic processes use various β‐integrin regulatory mechanisms to differing degrees and that conformational changes associated with outside‐in activation are essential for developmental integrin functions. Long‐term adhesion is also sensitive to integrin dysregulation, suggesting integrins must be continuously regulated to support stable tissue maintenance. Altogether, in vivo phenotypic analyses allowed us to identify the importance of various β‐integrin regulatory mechanisms during different morphogenetic processes. Developmental Dynamics 240:36–51, 2011. © 2010 Wiley‐Liss, Inc.
Spiral microdisk resonator-based channel filters on a silicon chip: probing the out-of-plane scattering spectra

We report our latest experimental results in spectrally characterizing silicon-based spiral microdisk resonators as 3-port channel filters, with one waveguide non-evanescently coupled to the spiral notch. We also show initial measurements of the resonance modes out-of-plane scattering that are probed using a lensed singlemode fiber scanning at a micrometer-distance above the microdisk.
Un inédit de Maurice Merleau-Ponty

Le texte publie ci-apres est celui (Tun expose que me remit son auteur au moment ou f 'etablissais , pour sa candidature au College de France, le rapport destine a presenter ses titres devant V Assemblee des professeurs. Merleau-Ponty joint la, d'un trait continu, son passe et son avenir de philosophe, esquisse les perspectives de ses recherches futures depuis /'Origine de la Verite jusqu'a /'Homme transcendantal. En lisant ces lignes inedites, d'un si haut interet, le regret s'avive d'une mort qui a brutalement interrompu l'elan d'une pensee profonde, en pleine possession d'elle-meme, et sur le point de s'accomplir dans une serie d' œuvres originales qui eussent fait date dans la philosophie francaise contemporaine. Martial Gueroult.
Reelin, radial fibers and cortical evolution: Insights from comparative analysis of the mammalian and avian telencephalon

The mammalian cerebral cortex has a remarkable laminated structure, which is derived from the pallium, the dorsal part of the embryonic telencephalon. Recent studies indicate that the pallium is developed as a homologous structure in all vertebrate species. However, the cellular and molecular mechanism for making architectural diversity of the pallium is not fully understood. Here we introduce recent progress in comparative analysis of pallial development, and our data on the role of Reelin protein in the developing avian pallium. These experimental approaches to pallial development in non‐mammalian species will provide a new insight into evolution of the cerebral cortex.
In Vitro Antiparasitic Activity and Chemical Composition of the Essential Oil Obtained from the Fruits of Piper cubeba

Abstract Protozoans of the trypanosomatid family cause the neglected tropical diseases leishmaniasis and trypanosomiasis, for which few drugs are available. In this context our group has recently reported that the essential oil obtained by steam distillation of the fruits of Piper cubeba is active against Schistosoma mansoni. Therefore, we have investigated the in vitro effects of the essential oil against the trypomastigote and amastigote forms of Trypanosoma cruzi isolated from an LLCMK2 cell line culture and the promastigote forms of Leishmania amazonensis. The in vitro activity of the essential oil against trypomastigotes of T. cruzi increased upon rising concentrations, giving IC50 values of 45.5 and 87.9 µg · mL−1 against trypomastigotes and amastigotes, respectively. The essential oil was not active against L. amazonensis, since it displayed lyses of only 24 % at 400 µg · mL−1, and an IC50 of 326.5 µg · mL−1. Therefore, the essential oil should be further investigated to determine the compounds responsible for the observed activities, as well as its mechanism of action.
A promotion analysis of restrictive relative clauses

Face a l'impuissance de l'analyse des relatives restrictives complexes - proposee par Chomsky dans le cadre de la grammaire generative - a elucider certains problemes (les possibilites de liage et de co-reference des anaphores et des pronoms dans differents types de relatives par exemple), l'article propose une analyse de promotion non standard, qui promeut ou deplace l'antecedent. Cette methode s'avere particulierement adaptee aux structures syntaxiques norvegiennes.
Silibinin inhibits UVB- and epidermal growth factor–induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-κB in mouse epidermal JB6 cells

UVB radiation is the major etiologic factor in the development of nonmelanoma skin cancer. In addition to tumor-initiating effect, UVB also causes tumor promotion via mitogenic and survival signaling. Studies have shown strong preventive effects of silibinin against both UVB-induced and chemically induced tumor promotion in mouse skin models; however, mechanisms are not understood completely. Here, we used tumor promoter–sensitive JB6 mouse epithelial cell model and studied the effect of silibinin on two different mitogens [UVB and epidermal growth factor (EGF)] that induce mitogenic and cell survival signaling pathways. UVB (50–800 mJ/cm2) dose-dependently induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun-NH2-kinase 1/2 (JNK1/2), and p38 kinase (p38K) as well as Akt, with an optimum response at 400 mJ/cm2 UVB dose. UVB caused a biphasic phosphorylation of ERK1/2 in a time kinetics study. Silibinin treatment before or immediately after UVB exposure, or both, resulted in a strong decrease in UVB-caused phosphorylation of ERK1/2 and Akt in both dose- and time-dependent manner, without any substantial response on JNK1/2 and p38K. Silibinin also suppressed UVB-induced activator protein-1 (AP-1) and nuclear factor-κB (NF-κB) activation, which are activated by ERK1/2 and Akt. Silibinin treatment under similar conditions also strongly inhibited EGF-induced ERK1/2, JNK1/2, and p38K as well as Akt phosphorylation, and also suppressed EGF-induced AP-1 and NF-κB activation. Because AP-1 and NF-κB are important nuclear transcription factors for tumor promotion, these results suggest that silibinin possibly prevents skin tumor promotion by inhibiting UVB- and EGF-induced mitogenic and cell survival signaling involving both AP-1 and NF-κB. [Mol Cancer Ther 2006;5(5):1145–53]
Influence of weight initialization on multilayer perceptron performance

This paper presents a new algorithm for initializing the weights in multilayer perceptrons. This method is based on the use of feature vectors extracted by discriminant analysis. Simulations carried out with real-world and synthetic data sets show that the proposed algorithm allows to obtain a better initial state, as compared to random initialization. As a result, training time is reduced and lower generalization error can be achieved. Additionally, it is shown through numerical simulations that the generalization performance of networks initialized with the proposed method becomes less sensitive to network size and input dimension.