Miracle-dz/UniFAR-FTUs huggingface dataset:
Overexpression of proCOL11A1 as a stromal marker of breast cancer.

BACKGROUND Our previous studies demonstrated the expression of procollagen11A1 in fibroblasts of pancreatic cancer desmoplasia and the lack of expression in fibroblasts of pancreatitis by means of the polyclonal antibody (anti-proCOL11A1 pAb) we generated. In a similar way, we decided to compare the expression of procollagen11A1 in fibroblasts of infiltrating ductal carcinoma of the breast and fibroblasts of benign sclerosing lesions of the breast, in order to validate the anti-proCOL11A1 pAb in this setting and to study how proCOL11A1 expression relates to other prognostic and predictive factors, as well as to survival. METHODS 45 core biopsies of sclerosing adenosis and 50 core biopsies of infiltrating ductal carcinoma of the breast were stained with anti-proCOL11A1 pAb, a polyclonal antibody highly specific to the less homologous fraction of proCOL11A1 (in comparison with proCOL5A1 and proCOL11A2). In addition, the expression of the proCOL11A1 gene was measured by RT-qPCR. On the other hand, the expression of proCOL11A1 was compared to the expression of estrogenic receptors, progestagen receptors, the state of the epidermal growth factor receptor 2 (HER2), the histologic grade and the stage of the disease. We also compared the immunohistochemical expression of proCol11A1 to the disease-free interval, and to overall survival. RESULTS The immunohistochemical analysis showed that proCOL11A1 was expressed in 100% of infiltrating ductal carcinomas, but only focally expressed in 2.2% (1 case) of sclerosing adenosis, in agreement with RT-qPCR results. ProCOL11A1 expression did not prove to have a prognostic value in relation to the disease-free interval or to overall survival in infiltrating ductal carcinoma. CONCLUSION The anti-proCOL11A1 pAb is a stromal marker for breast cancer and the expression of proCOL11A1 does not seem to have a prognostic value in infiltrating ductal carcinoma of the breast.
Subband-Landau-level coupling in GaAs/Ga1-xAlxAs heterojunctions.

We study the coupling of Landau levels and electric subbands in quasi-two-dimensional electron inversion layers of modulation-doped GaAs/${\mathrm{Ga}}_{1\mathrm{\ensuremath{-}}\mathrm{x}}$${\mathrm{Al}}_{\mathrm{x}}$As heterojunctions in tilted magnetic fields. We employ far-infrared Fourier-transform spectroscopy with light polarized parallel to the layers. When the subband separation ${E}_{10}$ is much larger than the cyclotron energy \ensuremath{\Elzxh}${\ensuremath{\omega}}_{c}$, we find an enhancement of the cyclotron mass due to the parallel magnetic-field component. When the subband separation ${E}_{10}$=r\ensuremath{\Elzxh}${\ensuremath{\omega}}_{c}$ is a multiple r=1,2 of the cyclotron energy, we observe a resonant splitting of the cyclotron resonance. The mass enhancement as well as the magnitudes and energetic positions of the splittings are described by perturbation theory and by the triangular-well approximation of the space-charge potential. From the experimental data we determine intersubband energies and dipole matrix elements. Both depend on electron density, which we adjust by illumination with a light-emitting diode or by a gate voltage applied between the inversion layer and a front gate.
MAC layer cooperation analysis in cognitive wireless networks

Cognition and cooperation are two concepts closely connected in Cognitive Wireless Networks. In such distributed networks, where there is not any central node responsible for retrieving/forwarding the information from/to all the users, the monitoring of the spectrum availability must be carried out also in a distributed fashion. However, there exists a trade-off between the amount of monitoring information shared among the users and the overhead introduced to the network, particularly when users are equipped with a single antenna. As primary users may suddenly transmit on any licensed channel, all secondary users should monitor periodically alternative idle channels where to resume the ongoing communications in case such a situation occurs. In this paper we analyze the minimum spectrum monitoring frequency required for users to have a number of alternative idle channels.
Postparotidectomy facial nerve paralysis: peripheral versus proximal identification.

OBJECTIVES Facial nerve palsy is a distressing complication of parotid surgery. We determined to analyse parotid surgery outcomes in a district general hospital in order to identify our own risk factors leading to increased incidence of facial nerve palsy. Primarily, we aimed to determine the efficacy of peripheral versus proximal facial nerve identification in preventing facial nerve damage. METHODS This was a retrospective study of hospital records. The records of sixty-four patients aged between 32 and 84 years who had attended our Otolaryngology department over a six-year period were analysed, with notes made of operative procedure, identification of the facial nerve and post-operative facial nerve palsy. The Neurosign400 facial nerve monitor was used and the degree of facial nerve paralysis was assessed using the House Brackmann (HB) classification of facial nerve paralysis. RESULTS Sixty-four patients underwent parotidectomy. Thirty-two patients had the peripheral branch of the facial nerve identified while another thirty-two patients had proximal nerve identification. Six patients had HB 2 facial nerve palsy, but all completely recovered within six months. Four out of the six patients had peripheral identification of the facial nerve. CONCLUSIONS Although peripheral versus proximal identification of the facial nerve was associated with greater incidence of temporary facial nerve paralysis, all the patients recovered within six months. This study may indicate that exposing a peripheral branch of the facial nerve with the help of Neurosign400 is a useful way of performing parotidectomy where proximal identification of a nerve is not possible.
2-{[4-(Pyridin-2-yl)pyrimidin-2-yl]sulfanyl}acetic acid

In the title molecule, C11H9N3O2S, the pyridine and pyrimidine rings are almost parallel [dihedral angle = 6.7 (1)°]. In the crystal, adjacent molecules are joined by O—H⋯N and C—H⋯O hydrogen bonds, leading to the formation of a sheet parallel to (10).
A Novel Putrescine Importer Required for Type 1 Pili-driven Surface Motility Induced by Extracellular Putrescine in Escherichia coli K-12*

Recently, many studies have reported that polyamines play a role in bacterial cell-to-cell signaling processes. The present study describes a novel putrescine importer required for induction of type 1 pili-driven surface motility. The surface motility of the Escherichia coli ΔspeAB ΔspeC ΔpotABCD strain, which cannot produce putrescine and cannot import spermidine from the medium, was induced by extracellular putrescine. Introduction of the gene deletions for known polyamine importers (ΔpotE, ΔpotFGHI, and ΔpuuP) or a putative polyamine importer (ΔydcSTUV) into the ΔspeAB ΔspeC ΔpotABCD strain did not affect putrescine-induced surface motility. The deletion of yeeF, an annotated putative putrescine importer, in the ΔspeAB ΔspeC ΔpotABCD ΔydcSTUV strain abolished surface motility in putrescine-supplemented medium. Complementation of yeeF by a plasmid vector restored surface motility. The surface motility observed in the present study was abolished by the deletion of fimA, suggesting that the surface motility is type 1 pili-driven. A transport assay using the yeeF+ or ΔyeeF strains revealed that YeeF is a novel putrescine importer. The Km of YeeF (155 μm) is 40 to 300 times higher than that of other importers reported previously. On the other hand, the Vmax of YeeF (9.3 nmol/min/mg) is comparable to that of PotABCD, PotFGHI, and PuuP. The low affinity of YeeF for putrescine may allow E. coli to sense the cell density depending on the concentration of extracellular putrescine.
Characterization of the Infectious Salmon Anemia Virus Genomic Segment That Encodes the Putative Hemagglutinin

ABSTRACT The genomic segment encoding the putative hemagglutinin of infectious salmon anemia virus (ISAV) is described. Expression of the putative hemagglutinin in a salmon cell line demonstrated hemadsorptive properties of the protein for salmon erythrocytes. The polypeptide was recognized by an ISAV-specific monoclonal antibody. Nucleotide sequencing indicated the occurrence of a variable region in the hemagglutinin gene.
Studies on the assembly of adenovirus in vitro.

Summary In vitro assembly of human adenovirus type 5 was studied using virus precursor materials from extracts of HeLa cells infected in Eagle's complete and arginine-free medium. Radioisotope studies suggested that factors having assembly activities in vitro were present only in extracts of cells infected in complete medium. Extracts containing these assembly factors were added to extracts of cells infected in arginine-free medium and the mixtures, after incubation in the presence of stabilizing buffer solutions, contained particles of the same density as complete virus particles formed in vivo. The newly assembled products were DNase-resistant and had 1.5 to 2 log. greater infectivity in plaque assays than either of the two extracts alone or in unassembled mixtures. The factor(s) responsible for the assembly activity were found to be associated predominantly with the nuclear fraction of the infected cells and they were produced in greatest amounts in extracts taken at 12 to 16 hr after infection. Assembly activity of the extracts was lost when they were subjected to temperatures above 32°, trypsin treatment and fluorocarbon extraction before adding them to experimental assembly mixtures.
Lightweight Directory Access Protocol (LDAP) and X.500 Component Matching Rules

The syntaxes of attributes in a Lightweight Directory Access Protocol (LDAP) or X.500 directory range from simple data types, such as text string, integer, or boolean, to complex structured data types, such as the syntaxes of the directory schema operational attributes. Matching rules defined for the complex syntaxes usually only provide the most immediately useful matching capability. This document defines generic matching rules that can match any user selected component parts in an attribute value of any arbitrarily complex attribute syntax.
Construction of SEU Tolerant Flip-Flops Allowing Enhanced Scan Delay Fault Testing

In recent high-density VLSIs, soft errors, particularly single event upsets (SEUs), frequently occur during system operation. In addition, the occurrence of delay faults caused by manufacturing defects is a significant problem. Thus, SEU tolerant design and delay fault testing are of increasing significance. This paper presents two types of SEU tolerant flip-flops (FFs). The proposed FFs tolerate SEUs caused by particles striking feedback loops in the FFs. Moreover, the proposed FFs allow enhanced scan delay fault testing. The proposed FFs are master-slave FFs, and the slave latches are constructed by modifying existing SEU tolerant latches, namely, SEH latches. The two proposed FFs tolerate particles with charges of 370 fC and of 369 fC or lower, whereas an existing SEU tolerant enhanced scan FF, called an ESFF-SEC, tolerates those of 431 fC or lower. Furthermore, the areas of the proposed FFs are 23.1% and 20.5% smaller than that of the ESFF-SEC. The CK-Q delay times are 44.4% and 41.1% shorter than that of the ESFF-SEC. Moreover, the average power consumptions of the proposed FFs during system operations are 55.6% and 53.3% lower than that of the ESFF-SEC.
The impact of obesity on cardiovascular disease risk factors and subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis.

BACKGROUND To assess the importance of the obesity epidemic on cardiovascular disease (CVD) risk, we determined the prevalence of obesity and the relationship of obesity to CVD risk factors and subclinical vascular disease. METHODS The Multi-Ethnic Study of Atherosclerosis is an observational cohort study involving 6814 persons aged 45 to 84 years who were free of clinical CVD at baseline (2000-2002). The study assessed the association between body size and CVD risk factors, medication use, and subclinical vascular disease (coronary artery calcium, carotid artery intimal medial thickness, and left ventricular mass). RESULTS A large proportion of white, African American, and Hispanic participants were overweight (60% to 85%) and obese (30% to 50%), while fewer Chinese American participants were overweight (33%) or obese (5%). Hypertension and diabetes were more prevalent in obese participants despite a much higher use of antihypertensive and/or antidiabetic medications. Obesity was associated with a greater risk of coronary artery calcium (17%), internal carotid artery intimal medial thickness greater than 80th percentile (32%), common carotid artery intimal medial thickness greater than 80th percentile (45%), and left ventricular mass greater than 80th percentile (2.7-fold greater) compared with normal body size. These associations persisted after adjustment for traditional CVD risk factors. CONCLUSIONS These data confirm the epidemic of obesity in most but not all racial and ethnic groups. The observed low prevalence of obesity in Chinese American participants indicates that high rates of obesity should not be considered inevitable. These findings may be viewed as indicators of potential future increases in vascular disease burden and health care costs associated with the obesity epidemic.
Using deep learning to enhance event geometry reconstruction for the telescope array surface detector

The extremely low flux of ultra-high energy cosmic rays (UHECR) makes their direct observation by orbital experiments practically impossible. For this reason all current and planned UHECR experiments detect cosmic rays indirectly by observing the extensive air showers (EAS) initiated by cosmic ray particles in the atmosphere. The world largest statistics of the ultra-high energy EAS events is recorded by the networks of surface stations. In this paper we consider a novel approach for reconstruction of the arrival direction of the primary particle based on the deep convolutional neural network. The latter is using raw time-resolved signals of the set of the adjacent trigger stations as an input. The Telescope Array (TA) Surface Detector (SD) is an array of 507 stations, each containing two layers plastic scintillator with an area of 3 m2. The training of the model is performed with the Monte-Carlo dataset. It is shown that within the Monte-Carlo simulations, the new approach yields better resolution than the traditional reconstruction method based on the fitting of the EAS front. The details of the network architecture and its optimization for this particular task are discussed.
Grid file declustering, an implementation of a multidimensional indexing strategy

The paper describes work on the implementation of a grid file based declustering strategy on a prototype multiprocessor database machine, MEDUSA. The paper discusses the implementation techniques used by the authors and reviews the effectiveness of a grid file indexing system within a multiprocessor environment. The MEDUSA prototype is based on a shared nothing architecture, each transaction node comprising a IMMOS T805 transputer and a T222 SCSI interface to a 180 Mb disk drive.
A Riemannian-Geometry Approach for Modeling and Control of Dynamics of Object Manipulation under Constraints

A Riemannian-geometry approach for modeling and control of dynamics of object manipulation under holonomic or non-holonomic constraints is presented. First, position/force hybrid control of an endeffector of a multijoint redundant (or nonredundant) robot under a holonomic constraint is reinterpreted in terms of “submersion” in Riemannian geometry. A force control signal constructed in the image space of the constraint gradient is regarded as a lifting (or pressing) in the direction orthogonal to the kernel space. By means of the Riemannian distance on the constraint submanifold, stability of position control under holonomic constraints is discussed. Second, modeling and control of two-dimensional object grasping by a pair of multijoint robot fingers are challenged, when the object is of arbitrary shape. It is shown that rolling contact constraints induce the Euler equation of motion, in which constraint forces appear as wrench vectors affecting the object. The Riemannian metric is introduced on a constraint submanifold characterized with arclength parameters. An explicit form of the quotient dynamics is expressed in the kernel space with accompaniment of a pair of first-order differential equations concerning the arclength parameters. An extension of Dirichlet-Lagrange's stability theorem to redundant systems under constraints is suggested by introducing a Morse-Lyapunov function.
Optimizing fiber coupling with a quasi-passive microoptical bench

While the silicon microoptical bench with purely passive locational features was an attempt at breadboard-like integration for photonic applications, it failed to provide the high-precision alignment required for efficient light coupling between devices and/or fibers. To optimize the final alignment without the introduction of on-board active actuators or external high-precision manipulators, we have developed and demonstrated a low-cost, micromachined optical bench with quasipassive locational features capable of submicron alignment optimization. The concept capitalizes on inherent residual tensile stresses produced during the stoichiometric Si/sub 3/N/sub 4/ thin-film deposition process. By selectively trimming stress element on either side of a suspended platform, the equilibrium position can be biased to one side or another, enabling high-resolution relative motion between the suspended platform and the base. We have demonstrated, as a first attempt, high-efficiency fiber-to-fiber alignment using this concept. [1556].
Physical Human-Robot Interaction With a Tethered Aerial Vehicle: Application to a Force-Based Human Guiding Problem

Today, physical human-robot interaction (pHRI) is a very popular topic in the field of ground manipulation. At the same time, aerial physical interaction is also developing very fast. Nevertheless, pHRI with aerial vehicles has not been addressed so far. In this work, we present the study of one of the first systems in which a human is physically connected to an aerial vehicle by a cable. We want the robot to be able to pull the human toward a desired position (or along a path) only using forces as an indirect communication-channel. We propose an admittance-based approach with a controller, inspired by the literature on flexible manipulators, that computes the desired interaction forces that properly guide the human. The stability of the system is formally proved with a Lyapunov-based argument. The system is also shown to be passive, and thus robust to nonidealities like model and tracking errors, additional human forces, time-varying inputs, and other external disturbances. We also design a maneuver regulation policy to simplify the path following problem. The global method has been experimentally validated on a group of four subjects, showing a reliable and safe pHRI.
Predictive encoderless control of back-to-back converter PMSG wind turbine systems with Extended Kalman Filter

This paper presents a deadbeat-like predictive encoderless control method for back-to-back power converter permanent-magnet synchronous generator (PMSG) wind turbine systems with Extended Kalman Filter (EKF). The generator state variables are estimated through an EKF observer requiring neither the knowledge of mechanical parameters nor the initial position of the rotor. The estimated speed and position are fed into a deadbeat predictive controller using SVM. The grid side control is realized by a deadbeat predictive power controller requiring little tuning efforts. Both the estimator and predictive controllers are implemented on a fully FPGA based platform, using the single-cycle-timed-loop technique, achieving very short calculating time. The effectiveness of the presented method is verified with experimental data.
Relations between Science Activities of STEAM and Job Choice on High School Students

The purpose of this study is to find out how students recognize science experiential activities of STEAM (science, technology, engineering, arts, and mathematics) in science high school and to analyze how they effect on students' choice of job and to suggest improvements of activities to have impact on students positively. The conclusions of research result are as follows. First, Students remembered science experiential activities of STEAM more than general science experiential activities. Second, science experiential activity of STEAM affected to students' choice of job path positively.
Differentially Private Matrix Completion, Revisited

We study the problem of privacy-preserving collaborative filtering where the objective is to reconstruct the entire users-items preference matrix using a few observed preferences of users for some of the items. Furthermore, the collaborative filtering algorithm should reconstruct the preference matrix while preserving the privacy of each user. We study this problem in the setting of joint differential privacy where each user computes her own preferences for all the items, without violating privacy of other users' preferences. We provide the first provably differentially private algorithm with formal utility guarantees for this problem. Our algorithm is based on the Frank-Wolfe (FW) method, and consistently estimates the underlying preference matrix as long as the number of users $m$ is $\omega(n^{5/4})$, where $n$ is the number of items, and each user provides her preference for at least $\sqrt{n}$ randomly selected items. We also empirically evaluate our FW-based algorithm on a suite of datasets, and show that our method provides nearly same accuracy as the state-of-the-art non-private algorithm, and outperforms the state-of-the-art private algorithm by as much as 30%.
A bilinear feature extraction method for rapid serial visual presentation triage

Searching for target objects in large volume imagery is a challenging problem, and the rapid serial visual presentation (RSVP) triage based on the detection of event-related potentials (ERP) is potentially a promising solution to the problem. Due to the fact that ERP elicited by targets and those by non-targets differ not only on spatial patterns but temporal patterns, this paper proposes a feature extraction method namely bilinear common spatial pattern (BCSP), which is designed to capture discriminative spatio-temporal features of ERP for triage classification. The proposed method extends common spatial pattern (CSP) by incorporating the core idea of bilinear discriminant analysis (BDA) into it. Specifically, in addition to the spatial filters which CSP also looks for, BCSP acquires the temporal filters for learning the temporal patterns of ERP. Both the spatial filters and temporal filters are obtained by using the same Ramoser's technique, but in an iterative manner. With discriminative temporal information involved, BCSP has manifested remarkable advantages in RSVP triage experiments, as demonstrated by a significant increase of 11.2% in average classification accuracy in comparison with CSP, with p < 0.001 in paired t-test.