Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical cutoffs for adherence barriers in solid organ transplant recipients: how many is too many?

OBJECTIVE The current study used multiple statistical methods to determine empirically derived and clinically relevant cutoff scores on the Adolescent Medication Barriers Scale (AMBS) and Parent Medication Barriers Scale (PMBS) to detect adolescents and young adults with solid organ transplants who experienced medication nonadherence or negative medical outcomes. METHODS Participants included 71 patients and 80 caregivers. Cutoff scores were determined via receiver operating characteristic curve analyses, t-test analyses, and the sensitivity and specificity of using certain cutoff scores. RESULTS AMBS scores of ≥3 barriers and PMBS scores of ≥2 barriers were determined as the ideal cutoffs for identifying patients meeting criteria for the outcome variables. CONCLUSIONS Clinicians should consider using these recommended cutoff scores when assessing adherence barriers in adolescents and young adults with solid organ transplants and their families. Patients or caregivers endorsing barriers above the cutoffs may benefit from further assessment or intervention to address barriers, nonadherence, or related medical issues.
Use of Different Proteases to Obtain Flaxseed Protein Hydrolysates with Antioxidant Activity

The antioxidant activity of flaxseed protein hydrolysates obtained using five different enzymes was evaluated. Proteins were isolated from flaxseed cake and were separately treated with papain, trypsin, pancreatin, Alcalase and Flavourzyme. The degree of hydrolysis (DH) was determined as the percentage of cleaved peptide bonds using a spectrophotometric method with o-phthaldialdehyde. The distribution of the molecular weights (MW) of the hydrolysis products was profiled using Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis (Tricine-SDS-PAGE) and size exclusion-high performance liquid chromatography (SE-HPLC) separations. The antioxidant activities of the protein isolate and hydrolysates were probed for their radical scavenging activity using 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) radical cation (ABTS•+) and photochemiluminescence (PCL-ACL) assays, and for their ferric reducing antioxidant power (FRAP) and ability to bind Fe2+. The hydrolysates were more effective as antioxidants than the protein isolate in all systems. The PCL-ACL values of the hydrolysates ranged from 7.2 to 35.7 μmol Trolox/g. Both the FRAP and ABTS•+ scavenging activity differed among the hydrolysates to a lower extent, with the ranges of 0.20–0.24 mmol Fe2+/g and 0.17–0.22 mmol Trolox/g, respectively. The highest chelating activity (71.5%) was noted for the pancreatin hydrolysate. In general, the hydrolysates obtained using Alcalase and pancreatin had the highest antioxidant activity, even though their DH (15.4% and 29.3%, respectively) and the MW profiles of the peptides varied substantially. The O2•− scavenging activity and the ability to chelate Fe2+ of the Flavourzyme hydrolysate were lower than those of the Alcalase and pancreatin hydrolysates. Papain was the least effective in releasing the peptides with antioxidant activity. The study showed that the type of enzyme used for flaxseed protein hydrolysis determines the antioxidant activity of the hydrolysates.
Tuning J2EE Application Servers

Ever since the introduction of the J2EE Enterprise Application specification from SUN Microsystems, this new technology has experienced tremendous growth. This paper will discuss tuning approaches for J2EE application servers. After covering tuning options at the architectural level of a J2EE application, we discuss the impact of garbage collection and the JVM on application server performance, talk about benchmarking, load-testing and monitoring of applications servers.
MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected Mice

ABSTRACT The worst known H1N1 influenza pandemic in history resulted in more than 20 million deaths in 1918 and 1919. Although the underlying mechanism causing the extreme virulence of the 1918 influenza virus is still obscure, our previous functional genomics analyses revealed a correlation between the lethality of the reconstructed 1918 influenza virus (r1918) in mice and a unique gene expression pattern associated with severe immune responses in the lungs. Lately, microRNAs have emerged as a class of crucial regulators for gene expression. To determine whether differential expression of cellular microRNAs plays a role in the host response to r1918 infection, we compared the lung cellular “microRNAome” of mice infected by r1918 virus with that of mice infected by a nonlethal seasonal influenza virus, A/Texas/36/91. We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. Moreover, we observed significant enrichment in the number of predicted cellular target mRNAs whose expression was inversely correlated with the expression of these microRNAs. Intriguingly, gene ontology analysis revealed that many of these mRNAs play roles in immune response and cell death pathways, which are known to be associated with the extreme virulence of r1918. This is the first demonstration that cellular gene expression patterns in influenza virus-infected mice may be attributed in part to microRNA regulation and that such regulation may be a contributing factor to the extreme virulence of the r1918.
Landslide tsunami case studies using a Boussinesq model and a fully nonlinear tsunami generation model

Case studies of landslide tsunamis require integration of marine geology data and interpretations into numerical simulations of tsunami attack. Many landslide tsunami generation and propagation models have been proposed in recent time, further motivated by the 1998 Papua New Guinea event. However, few of these models have proven capable of integrating the best available marine geology data and interpretations into successful case studies that reproduce all available tsunami observations and records. We show that nonlinear and dispersive tsunami propagation models may be necessary for many landslide tsunami case studies. GEOWAVE is a comprehensive tsunami simulation model formed in part by combining the Tsunami Open and Progressive Initial Conditions System (TOPICS) with the fully non-linear Boussinesq water wave model FUNWAVE. TOPICS uses curve fits of numerical results from a fully nonlinear potential flow model to provide approximate landslide tsunami sources for tsunami propagation models, based on marine geology data and interpretations. In this work, we validate GEOWAVE with successful case studies of the 1946 Unimak, Alaska, the 1994 Skagway, Alaska, and the 1998 Papua New Guinea events. GEOWAVE simulates accurate runup and inundation at the same time, with no additional user interference or effort, using a slot technique. Wave breaking, if it occurs during shoaling or runup, is also accounted for with a dissipative breaking model acting on the wave front. The success of our case studies depends on the combination of accurate tsunami sources and an advanced tsunami propagation and inundation model.
Cardiovascular Disorders and Obstructive Sleep Apnea Syndrome

The first polysomnographic recordings with concomitant monitoring of cardiocirculatory parameters demonstrated that obstructive apneas arising during sleep are accompanied by a marked increase in pulmonary and systemic arterial pressure and severe alveolar hypoventilation. Apneas also may give rise to cardiac arrhythmias, namely potentially life-threatening bradyarrhythmias. The long-term repercussions of these nocturnal cardiocirculatory changes on subsequent cardiovascular diseases and the patient's life expectancy are more controversial. There is little doubt that patients with obstructive sleep apnea syndrome (OSAS) have systemic arterial hypertension, ischemic heart disease, transient ischemic attacks, or stroke more often than control populations and have a shorter life expectancy. However, these clinical manifestations may be at least partly due to myriad other risk factors almost always present in OSAS patients (in particular obesity, diabetes, alcoholism, and cigarette smoking). Few multivariate epidemiological surveys have addressed all these confounding factors. The effectiveness of continuous positive airway pressure treatment in reducing the incidence of cardiovascular comorbidity in OSAS patients is not disputed, even though controlled epidemiological surveys on large populations are scant. This overview of cardiovascular disorders and OSAS examines the latest literature findings aimed at establishing the true impact of nocturnal apneas on cardiocirculatory disease (systemic arterial hypertension, ischemic heart disease, stroke, pulmonary hypertension and right heart failure and mortality).
Cyber-Physical System Security With Deceptive Virtual Hosts for Industrial Control Networks

A challenge facing industrial control network administrators is protecting the typically large number of connected assets for which they are responsible. These cyber devices may be tightly coupled with the physical processes they control and human induced failures risk dire real-world consequences. Dynamic virtual honeypots are effective tools for observing and attracting network intruder activity. This paper presents a design and implementation for self-configuring honeypots that passively examine control system network traffic and actively adapt to the observed environment. In contrast to prior work in the field, six tools were analyzed for suitability of network entity information gathering. Ettercap, an established network security tool not commonly used in this capacity, outperformed the other tools and was chosen for implementation. Utilizing Ettercap XML output, a novel four-step algorithm was developed for autonomous creation and update of a Honeyd configuration. This algorithm was tested on an existing small campus grid and sensor network by execution of a collaborative usage scenario. Automatically created virtual hosts were deployed in concert with an anomaly behavior (AB) system in an attack scenario. Virtual hosts were automatically configured with unique emulated network stack behaviors for 92% of the targeted devices. The AB system alerted on 100% of the monitored emulated devices.
Motor Neurone Disease (MND) and Amyotrophic Lateral Sclerosis (ALS): Social Media Communication on Selected #MND and #ALS Tagged Tweets

In March-April 2016, 3288 original tweets tagged with #MND #ALS and other minor related tags (e.g., #cureALS #cureMND) were analysed using mixed quantitative and qualitative methods on tweet data and content. In this paper we outline the technical methods used in gathering and selecting relevant tweets for analysis, and present the results including inductive coding of content themes. The findings will inform (a) future social media research in relation to MND/ALS, (b) improved supports for people with MND/ALS and their families to use Twitter for information exchange, advocacy, and as a non-verbal form of communication, and (c) knowledge for MND/ALS service providers and philanthropic organisations on ways to engage with adults with MND/ALS in Twitter.
Are we there yet? Are we there yet? An exploratory study of baby boomers travelling with their grandchildren

[Abstract]: This paper is designed as an exploratory study to ascertain if ‘baby boomers’ who are grandparents want to travel with their grandchild/ren and what they are seeking when they do. It is anticipated that a typology of the ‘gran’ (either gender) who is a ‘baby boomer’ will be developed. Questionnaires will be used to research the level of service, facilities, choices, safety, convenience, security, destination, travel arrangements comfort and guest room facilities both they and their grandchildren will require. Thus developing a profile of this exciting market for the tourism industry to be better equipped to develop and deliver products which will meet or hopefully exceed the expectation of the ‘baby boomer’ cohort.
Perfect Simulation of Point Processes Given Noisy Observations

The paper is concerned with the Bayesian analysis of point processes which are observed with noise. It is shown how to produce exact samples from the posterior distribution of the unobserved true point process given a noisy observation. The algorithm is a perfect simulation method which applies dominated coupling from the past to a spatial birth-and-death process. Dominated coupling from the past is made amenable by augmenting the state space of the target chain. We discuss how to optimize this perfect simulation algorithm and how to use it in a statistical inference problem of pratical importance. We further describe the merits and the limitations of the method.
Optimization of All-to-All Communication on the Blue Gene/L Supercomputer

All-to-all communication is a well known performance bottleneck for many applications, such as the ones that use the Fast-Fourier-transform (FFT) algorithm. We analyze the performance of all-to-all communication on the BlueGene/L torus interconnect that has link contention even for all-to-all operations with short messages. We observed that the performance of all-to-all depends on the shape of the processor partition. We present a performance analysis of all-to-all on partitions of various shapes. We then present optimization schemes that substantially improve the performance of all-to-all with short and large messages.In particular, throughput improved from 64% to over 99% of peak on the 65,536 (64 times 32 times 32) node Blue Gene/L machine at the Lawrence Livermore National Lab. We show the impact of the all-to-all performance optimizations in 1-D and 3-D FFT benchmarks. We achieved a performance of over 2.8 TF for the HPC Challenge 1D FFT benchmark with our optimized all-to-all.
A METHOD FOR COMPUTING ALL MAXIMALLY GENERAL RULES IN ATTRIBUTE‐VALUE SYSTEMS

A method for finding all deterministic and maximally general rules for a target classification is explained in detail and illustrated with examples. Maximally general rules are rules with minimal numbers of conditions. The method has been developed within the context of the rough sets model and is based on the concepts of a decision matrix and a decision function. The problem of finding all the rules is reduced to the problem of computing prime implicants of a group of associated Boolean expressions. The method is particularly applicable to identifying all potentially interesting deterministic rules in a knowledge discovery system but can also be used to produce possible rules or nondeterministic rules with decision probabilities, by adapting the method to the definitions of the variable precision rough sets model.
Immunodetection of fungal and oomycete pathogens: Established and emerging threats to human health, animal welfare and global food security

Abstract Filamentous fungi (moulds), yeast-like fungi, and oomycetes cause life-threatening infections of humans and animals and are a major constraint to global food security, constituting a significant economic burden to both agriculture and medicine. As well as causing localized or systemic infections, certain species are potent producers of allergens and toxins that exacerbate respiratory diseases or cause cancer and organ damage. We review the pathogenic and toxigenic organisms that are etiologic agents of both animal and plant diseases or that have recently emerged as serious pathogens of immunocompromised individuals. The use of hybridoma and phage display technologies and their success in generating monoclonal antibodies for the detection and control of fungal and oomycete pathogens are explored. Monoclonal antibodies hold enormous potential for the development of rapid and specific tests for the diagnosis of human mycoses, however, unlike plant pathology, their use in medical mycology remains to be fully exploited.
Evidence that Self-Regulatory Mode Affects Retirement Savings

We examine how self-regulatory motivations of locomotion (initiation) and assessment (evaluation) are related to retirement wealth in middle-aged and older Americans. We test a hypothesis that high locomotion and some assessment levels predict high wealth levels. We use two national data sets: the 2008 Health and Retirement Study (N = 6,464) and the 2005 Midlife in the United States (N = 4,963). We found that a combination of high locomotion and moderate assessment motivation can maximize wealth accumulation. By creating this combination of locomotion and assessment motivations, policy interventions can be more effective in motivating wealth accumulation for retirement, such as a required annual review of retirement savings plans and understandable disclosure of the plans' costs.
Blood pressure management in acute intracerebral hemorrhage: current evidence and ongoing controversies

Purpose of reviewSpontaneous intracerebral hemorrhage (ICH) is associated with high rates of morbidity and mortality. Although treatment options are limited, a potential acute medical intervention is blood pressure (BP) reduction. The review will summarize the current evidence and remaining knowledge gaps with respect to acute BP management in acute ICH. Recent findingsMore than 3000 patients were enrolled in seven prospective randomized-controlled clinical trials assessing the safety and efficacy of intensive BP reduction (target <140–150 mmHg systolic) compared with current guideline-recommended BP target (<180 mmHg) in acute ICH. Overall, these trials demonstrated that intensive BP reduction is well tolerated and may be associated with a modest improvement in functional outcomes. There is still no conclusive evidence that aggressive BP reduction is associated with attenuation of hematoma growth or mortality rates. Delayed time to enrolment and difficulty in achieving intensive BP targets in a timely fashion without stringent antihypertensive protocols may partially account for the absence of proven benefit. SummaryRecent trials have shown that BP lowering (<140 mmHg systolic) is well tolerated and may improve functional outcomes. Ongoing trials will provide insight into the overall benefit of early aggressive BP reduction in acute ICH.
Algebraic Characterisation of the H ∞ and H 2 Norms for Linear Continuous-Time Periodic Systems ∗

It is well-known that linear, periodically timevarying, continuous-time systems are formally equivalent to so-called lifted representations that are shift-invariant, but have spatially infinitedimensional inputs and outputs. By shift invariance, corresponding frequency-domain representations can be constructed. Indeed, it makes sense to use the H∞ norm of the associated frequencydomain symbol as a measure of system size. In fact, this is equal to the L[0,∞) induced norm of the system. As an alternative measure of system size a generalisation of the H2 norm, which characterises the impulsive response of the system, can also be defined. The purpose of this paper is to establish finite-dimensional, algebraic characterisations of these norms, for linear continuous-time periodic systems.
Fatal Transmissible Amyloid Encephalopathy: A New Type of Prion Disease Associated with Lack of Prion Protein Membrane Anchoring

Prion diseases are fatal neurodegenerative diseases of humans and animals characterized by gray matter spongiosis and accumulation of aggregated, misfolded, protease-resistant prion protein (PrPres). PrPres can be deposited in brain in an amyloid-form and/or non-amyloid form, and is derived from host-encoded protease-sensitive PrP (PrPsen), a protein normally anchored to the plasma membrane by glycosylphosphatidylinositol (GPI). Previously, using heterozygous transgenic mice expressing only anchorless PrP, we found that PrP anchoring to the cell membrane was required for typical clinical scrapie. However, in the present experiments, using homozygous transgenic mice expressing two-fold more anchorless PrP, scrapie infection induced a new fatal disease with unique clinical signs and altered neuropathology, compared to non-transgenic mice expressing only anchored PrP. Brain tissue of transgenic mice had high amounts of infectivity, and histopathology showed dense amyloid PrPres plaque deposits without gray matter spongiosis. In contrast, infected non-transgenic mice had diffuse non-amyloid PrPres deposits with significant gray matter spongiosis. Brain graft studies suggested that anchored PrPsen expression was required for gray matter spongiosis during prion infection. Furthermore, electron and light microscopic studies in infected transgenic mice demonstrated several pathogenic processes not seen in typical prion disease, including cerebral amyloid angiopathy and ultrastructural alterations in perivascular neuropil. These findings were similar to certain human familial prion diseases as well as to non-prion human neurodegenerative diseases, such as Alzheimer's disease.
Dynamic scope of control in decentralized job scheduling

Each job scheduling agent in large decentralized load balancing systems generally has a set of remote hosts (i.e., its scope of control) to consider for offloading when the local load is too high. Typically, each agent's scope of control includes all the hosts in the system. The potential performance benefits of limiting the size of each agent's scope of control are investigated. The larger the scope of control, the less often state information can lower the quality of load balancing decisions. The smaller the scope of control, the less opportunity an agent has for finding a lightly loaded host for offloading. Agents adaptively modify their scope of control over time based on feedback regarding the success of load balancing decisions and act as a self-organizing system to efficiently share available processing power. <<ETX>>
Variation of loop sequence alters stability of cytolethal distending toxin (CDT): Crystal structure of CDT from Actinobacillus actinomycetemcomitans

Cytolethal distending toxin (CDT) secreted by Actinobacillus actinomycetemcomitans induces cell cycle arrest of cultured cells in the G2 phase. The crystal structure of the natural form of A. actinomycetemcomitans DCT (aCDT) has been determined at 2.4 Å resolution. aCDT is a heterotrimer consisting of the three subunits, aCdtA, aCdtB, and aCdtC. Two crystallographically independent aCDTs form a dimer through interactions of the aCdtB subunits. The primary structure of aCDT has 94.3% identity with that of Haemophilus ducreyi CDT (hCDT), and the structure of aCDT is quite similar to that of hCDT reconstituted from the three subunits determined recently. However, the molecular packings in the crystal structures of aCDT and hCDT are quite different. A careful analysis of molecular packing suggests that variation of the amino acid residues in a nonconserved loop (181TSSPSSPERRGY192 of aCdtB and 181NSSSSPPERRVY192 of hCdtB) is responsible for the different oligomerization of very similar CDTs. The loop of aCdtB has a conformation to form a dimer, while the loop conformation of hCdtB prevents hCDT from forming a dimer. Although dimerization of aCDT does not affect toxic activity, it changes the stability of protein. aCDT rapidly aggregates and loses toxic activity in the absence of sucrose in a buffered solution, while hCDT is stable and retains toxic activity. Another analysis of crystal structures of aCDT and hCDT suggests that the receptor contact area is in the deep groove between CdtA and CdtC, and the characteristic “aromatic patch” on CdtA.