Miracle-dz/UniFAR-FTUs huggingface dataset:
Osteogenic index and changes in bone markers during a jump training program: a pilot study.

PURPOSE This study was designed as a proof-of-concept study to assess the osteogenic index (OI) and changes in bone markers during an 8-wk jump training program. On the basis of the OI, jumps were completed in one or two daily sessions with total jumps per day being equal. METHODS Seven males served as controls and participated in their normal strength training program. Fourteen males were divided into two groups, jumping once daily (J1x) or jumping twice daily (J2x), with a 6-h recovery period between sessions (J2x only). Jumping-type exercises were performed on a Plyo Press and started at 20 plyo-jumps per day, three times per week and progressed to 60 plyo-jumps per day, three times per week for the last 3 wk. Blood samples were collected at baseline and at 4 and 8 wk to determine serum concentrations of bone-specific alkaline phosphate and C-terminal telopeptides of type I collagen. RESULTS OI for each session and week were different (P < 0.05) between the two jumping groups (baseline OI per week, J1x = 28 +/- 0.9, J2x = 34 +/- 0.9). There was a significant change (P = 0.005) in bone-specific alkaline phosphate over time, with 8-wk values being significantly higher than baseline values (change from baseline: J1x = 2.7 +/- 1.4 microg.L-1, J2x = 3.5 +/- 1.3 microg.L-1). J2x had an overall mean change significantly different from zero. C-terminal telopeptides of type I collagen did not change significantly during the 8 wk. CONCLUSIONS The data demonstrate that the bone of young adult males does respond to a high-impact exercise. In addition, compared with completing all plyo-jumps in one session, the use of recovery periods between exercise sessions on the same day may result in positive changes in bone turnover, indicative of an osteogenic effect. The beneficial impact of the OI and how it can be used to design programs to influence bone turnover still remain to be determined.
Modeling and forecasting U. S. mortality

Abstract Time series methods are used to make long-run forecasts, with confidence intervals, of age-specific mortality in the United States from 1990 to 2065. First, the logs of the age-specific death rates are modeled as a linear function of an unobserved period-specific intensity index, with parameters depending on age. This model is fit to the matrix of U.S. death rates, 1933 to 1987, using the singular value decomposition (SVD) method; it accounts for almost all the variance over time in age-specific death rates as a group. Whereas e 0 has risen at a decreasing rate over the century and has decreasing variability, k(t) declines at a roughly constant rate and has roughly constant variability, facilitating forecasting. k(t), which indexes the intensity of mortality, is next modeled as a time series (specifically, a random walk with drift) and forecast. The method performs very well on within-sample forecasts, and the forecasts are insensitive to reductions in the length of the base period from 90 to 30 .
Smart-cut 6H-silicon carbide (SiC) microdisk torsional resonators with sensitive photon radiation detection

This digest paper reports experimental demonstration of a new type of microdisk torsional resonators based on a smart-cut 6H-silicon carbide (6H-SiC) technology. We carefully calibrate the thermomechanical vibrations of these torsional-mode resonators by employing highly sensitive laser interferometric readout techniques, with displacement sensitivities (i.e., limits of detection) at the levels of S<sub>x</sub><sup>1/2</sup>~0.1pmWHz and smaller. To utilize these first 6H-SiC torsional resonators, we further demonstrate sensitive detection of radiations from both blue (405nm) and infrared (IR 785nm) photons Toward force detection applications which torsional resonators are suitable, our measurements demonstrate an intrinsic force resolution of S<sub>F</sub><sup>1/2</sup>≈5 7fN√Hz and a torque resolution of S<sub>T</sub><sup>1/2</sup>≈3.7×10<sup>-20</sup> (N·m)√Hz, limited by the fundamental thermomechanical fluctuations.
Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet‐induced obesity

The chemokine receptor CXCR4 is expressed on adipocytes and macrophages in adipose tissue, but its role in this tissue remains unknown. We evaluated whether deficiency in either adipocyte or myeloid leukocyte CXCR4 affects body weight (BW) and adiposity in a mouse model of high‐fat‐diet (HFD)‐induced obesity. We found that ablation of adipocyte, but not myeloid leukocyte, CXCR4 exacerbated obesity. The HFD‐fed adipocyte‐specific CXCR4‐knockout (AdCXCR4ko) mice, compared to wild‐type C57BL/6 control mice, had increased BW (average: 52.0 g vs. 35.5 g), adiposity (average: 49.3 vs. 21.0% of total BW), and inflammatory leukocyte content in white adipose tissue (WAT), despite comparable food intake. As previously reported, HFD feeding increased uncoupling protein 1 (UCP1) expression (fold increase: 3.5) in brown adipose tissue (BAT) of the C57BL/6 control mice. However, no HFD‐induced increase in UCP1 expression was observed in the AdCXCR4ko mice, which were cold sensitive. Thus, our study suggests that adipocyte CXCR4 limits development of obesity by preventing excessive inflammatory cell recruitment into WAT and by supporting thermogenic activity of BAT. Since CXCR4 is conserved between mouse and human, the newfound role of CXCR4 in mouse adipose tissue may parallel the role of this chemokine receptor in human adipose tissue. —Yao, L. , Heuser‐Baker, J., Herlea‐Pana, O. , Zhang, N. , Szweda, L. I. , Griffin, T. M. , Barlic‐Dicen, J., Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet‐induced obesity. FASEB J. 28, 4534–4550 (2014). www.fasebj. org
Sucrose Efflux Mediated by SWEET Proteins as a Key Step for Phloem Transport

That Sweet Sensation Photosynthesis in the leaf generates sucrose that must be transported via the phloem to other parts of the plant in order, for example, to be incorporated into harvestable produce. Studying Arabidopsis and rice, Chen et al. (p. 207, published online 8 December; see the Perspective by Braun) identified the SWEET family of sucrose efflux transporters that are responsible for carrying sucrose out of the leaf cells. When the transporters were disabled, sucrose accumulated in the leaves. Functioning properly, the SWEET transporters carry sucrose across the plasma membrane and other transporters move it further into the phloem. Transporters hand off sucrose from production cell to transport cell. Plants transport fixed carbon predominantly as sucrose, which is produced in mesophyll cells and imported into phloem cells for translocation throughout the plant. It is not known how sucrose migrates from sites of synthesis in the mesophyll to the phloem, or which cells mediate efflux into the apoplasm as a prerequisite for phloem loading by the SUT sucrose–H+ (proton) cotransporters. Using optical sucrose sensors, we identified a subfamily of SWEET sucrose efflux transporters. AtSWEET11 and 12 localize to the plasma membrane of the phloem. Mutant plants carrying insertions in AtSWEET11 and 12 are defective in phloem loading, thus revealing a two-step mechanism of SWEET-mediated export from parenchyma cells feeding H+-coupled import into the sieve element–companion cell complex. We discuss how restriction of intercellular transport to the interface of adjacent phloem cells may be an effective mechanism to limit the availability of photosynthetic carbon in the leaf apoplasm in order to prevent pathogen infections.
Parasitism by Ixodes dammini (Acari: Ixodidae) and antibodies to spirochetes in mammals at Lyme disease foci in Connecticut, USA.

Wild and domestic mammals, collected during 1978–1982 from areas endemic for Lyme disease, were examined to determine prevalence of Ixodes dammini and were surveyed for antibodies against different strains of spirochetes. More than 66% of 656 small and medium-sized hosts had I. dammini immatures or adults; parasitism ranged from 21.4% of 28 Eastern Chipmunks to 84.2% of 38 Virginia Opossums. Indirect immunofluorescence (IF) tests detected antibodies to spirochetes in 197 (20.5%) of the 961 sera analyzed. Seropositivity for White-footed Mice, Virginia Opossums, Eastern Chipmunks, Raccoons, dogs, deer, and Gray Squirrels ranged from 10.3 to 50%. Samples of an additional 442 mammalian sera, representative of areas in western Connecticut where I. dammini is rare, were negative. Four strains of spirochetes isolated from I. dammini and feral mammals in northeastern United States reacted similarly in our indirect IF test.
Automatic difference measure between movies using dissimilarity measure fusion and rank correlation coefficients

When considering multimedia database growth, one current challenging issue is to design accurate navigation tools. End user basic needs, such as exploration, similarity search and favorite suggestions, lead to investigate how to find semantically resembling media. One way is to build numerous continuous dissimilarity measures from low-level image features. In parallel, an other way is to build discrete dissimilarities from textual information which may be available with video sequences. However, how such different measures should be selected as relevant and be fused? To this aim, the purpose of this paper is to compare all those various dissimilarities and to propose a suitable ranking fusion method for several dissimilarities. Subjective tests with human observers on the CITIA animation movie database have been carried out to validate the model.
Evaluation of maximal inspiratory and sniff nasal inspiratory pressures in pre- and postoperative myocardial revascularization.

OBJECTIVE The objective of this study was to evaluate and correlate inspiratory muscle strength using maximal inspiratory pressure (MIP) and sniff nasal inspiratory pressure (Pnsn) in patients with coronary artery disease in pre- and postoperative of myocardial revascularization surgery. METHODS Thirty-eight men were studied, divided into a control group (CG) comprised of healthy individuals (n=18), age 55.52 ± 7.8 years and a myocardial revascularization group (MRG), comprised of patients with coronary artery disease submitted to myocardial revascularization (n=20), age 58.44 ± 9.3 years. All volunteers were submitted to MIP and Pnsn measurement, and the MRG was evaluated in the preoperative period and on the first postoperative day (PO1). RESULTS MRG presented MIP (80.60 ± 26.60 cmH2O) and Pnsn (74.70 ± 31.80 cmH2O) values inferior to CG (MIP: 112.22 ± 32.00 cmH2O; Pnsn: 103.70 ± 34.10 cmH2O), and there was significant reduction of these values on PO1 (MIP: 40.05 ± 15.70 cmH2O; Pnsn: 40.05 ± 16.60 cmH2O). There was correlation and concordance between evaluation methods in both groups studied, as well as in pre- and postoperative MRG conditions. CONCLUSIONS The results showed that the studied patients presented reduced MIP and Pnsn pre- and post-operative myocardial revascularization. Also, the Pnsn correlated with MIP and can be considered suitable for assessing inspiratory muscle strength in this population.
Social Media Domain Analysis (SoMeDoA) - A Pharmaceutical Study

Social media data is increasingly becoming a valuable asset for marketing teams, and businesses are regularly coming up with new and innovative ways to make use of this data. A social media network (SMN) is able to connect enterprises with their customers, partners and even competitors. Public trading and relations-oriented structures of social media networks (SMN) have encouraged organizations to engage more actively with other transactional partners. Organizations are seeking to tap into the relationship development potential these websites offer, especially the network effect of each individuals or organisations social graph. It is recognized that these relationships (when utilised) are able to create value for network participants. This paper discusses SMN tools and outlines a methodology and procedure that supports the identification of domain specific networks within a global business-to-business environment. Research is carried out using SMN data about firms in the pharmaceutical industry. We use our own methodology to uncover market participants, linkages and prominent issues that may help new firms to position themselves effectively in a new marketplace. SMNs provide a considerable source of information and new methods are required to fully leverage their potential value. This paper explores how SMNs can be used as an effective source of business intelligence by analysing a popular SMN platform.
Bethesda 2001

The Bethesda system (TBS) for reporting cervical/vaginal cytological diagnoses was originally developed in 1988 at a National Cancer Institute (NCI) workshop convened to consider the benefits of increased standardization in the diagnostic reports provided by cytology laboratories. 1 It rapidly gained acceptance in laboratory practice in the USA and beyond 2, 3 and three years later the NCI sponsored another workshop to assess the use of TBS in practice and consider areas for improvement. 4 Subsequently an illustrated guide was published. 5
SQuAD reading comprehension deep learning model

We introduce a neural network model for reading comprehension using the SQuAD dataset. Our model is composed of a Dynamic Coattention Network encoder (Xiong et al. [2016]) and a novel decoder designed for runtime minimization. Our model obtained an F1 score of 52.283 when tested on the SQuAD dev set, and an exact-match score of 38.723.
Beampattern synthesis for concentric circular ring array using MMSE design

In a recent paper by Li et al. (2003), we proposed a method to achieve desired sidelobe level for broadband 3D beamforming using a discrete concentric circular ring array. To achieve an ideal sidelobe level using the previously proposed method, a sufficiently large number of array elements are required. If there are not enough array elements, sidelobe level is increased and uncontrollable. This paper proposes a pattern synthesis method based on the minimum mean-squared error (MMSE) criteria to achieve a better design when only insufficient array elements are available. The proposed method finds the optimal beamforming solution by minimizing the mismatched error between the synthesized and desired beampattern, which includes the error introduced by insufficient number of array elements. Experiments confirm the improvement on sidelobe control using the proposed design method.
A Hardware-Oblivious Optimizer for Data Stream Processing

High throughput and low latency are key requirements for data stream processing. This is achieved typically through different optimizations on software and hardware level, like multithreading and distributed computing. While any concept can be applied to particular systems, their impact on performance and their configuration can differ greatly depending on underlying hardware. Our goal is an optimizer for a stream processing engine (SPE) that can improve performance based on given hardware and query operators, supporting UDFs. In this paper, we consider different forms of parallelism and show measurements exemplarily with our SPE PipeFabric. We use a multicore and a manycore processor with Intel’s AVX/ AVX512 instruction set, leading to performance improvements through vectorization when some adaptations like microbatching are taken into account. In addition, the increased number of cores on a manycore CPU allows an intense exploitation of multithreading effects.
Comparison of the safety and efficacy of conventional monopolar and 2-micron laser transurethral resection in the management of multiple nonmuscle-invasive bladder cancer

Objectives To compare the safety and efficacy of conventional monopolar transurethral resection of bladder tumour (TURBT) and 2-micron continuous-wave laser resection (2-µm laser) techniques in the management of multiple nonmuscle-invasive bladder cancer (NMIBC), and to investigate long-term effects on tumour recurrence. Methods Patients with multiple NMIBC were randomized to receive TURBT or 2-µm laser in a nonblinded manner. All patients received intravesical chemotherapy with epirubicin (40 mg/40 ml) for 8 weeks, beginning 1 week after surgery, followed with monthly maintenance therapy for 12 months. Three-year follow-up data of preoperative, operative and postoperative management were recorded. Results In total, 120 patients were included: 56 in the TURBT group and 64 in the 2-µm laser group. Intra- and postoperative complications (including bladder perforation, bleeding and irritation) were less frequently observed in the 2-µm laser group compared with the TURBT group. There were no significant differences in first time to recurrence, overall recurrence or occurrence of urethral strictures. Conclusions The 2-µm laser resection method was more effective than TURBT in reducing rates of intra- and postoperative complications, but offered no additional benefit regarding tumour recurrence.
Characterization of HRV by Poincare Plot Analysis among the Female Tea Garden Workers of Northern Hilly Regions of West Bengal

Recent research on Heart Rate Variability HRV has proven that Poincare Plot is a powerful tool to mark Short Term and Long Term Heart Rate Variability. This study focuses a comprehensive characterization of HRV among the Tea Garden Workers of the Northern Hilly Regions of West Bengal. The characterization, as available from the data sets, projects the average values of SD1 characteristics, that is, Short Term HRV in females as 58.265ms and SD2 as 149.474. The SDRR shows a mean value of 87.298 with a standard deviation of 119.669 and the S Characterization as 16505.99 ms and Standard deviation of 45882.31 ms. The SDRR shows a mean value of 87.298 with a standard deviation of 119.669 and the S Characterization as 16505.99 ms and Standard deviation of 45882.31 ms. ApEn Characterization showed mean value of 0.961 and standard deviation of 0.274.
Nanoscale imaging of domain dynamics and retention in ferroelectric thin films

We report results on the direct observation of the microscopic origins of backswitching in ferroelectric thin films. The piezoelectric response generated in the film by a biased atomic force microscope tip was used to obtain static and dynamic piezoelectric images of individual grains in a polycrystalline material. We demonstrate that polarization reversal occurs under no external field (i.e., loss of remanent polarization) via a dispersive continuous-time random walk process, identified by a stretched exponential decay of the remanent polarization.
Neutrophil priming state predicts capillary leak after gut ischemia in rats.

BACKGROUND Multiple organ failure after serious injury or illness is a major determinant of mortality. An initial insult is believed to "prime" circulating neutrophils and induce systemic inflammation. Thereafter, a second insult will precipitate distant organ injury. The aim of these studies was to evaluate circulating neutrophil function after mesenteric ischemia-reperfusion to determine the neutrophil "priming state," a quantitative and clinically useful predictor of multiple organ failure. MATERIALS AND METHODS Anesthetized Sprague-Dawley rats underwent superior mesenteric artery occlusion for 30 min or sham operation and were euthanized after 2, 6, or 24 h of reperfusion. Control animals had blood taken without any intervention. To determine changes in lung capillary permeability, another group of rats received Evan's blue, a dye that binds albumin, 1 h before sacrifice. Flow cytometric analysis was performed on 5 million white blood cells after removal of red cells by lysis and centrifugation. Neutrophil number, oxidative burst, and CD18 expression were measured. RESULTS The number of circulating neutrophils was elevated similarly in rats subjected to sham operation or ischemia-reperfusion. Oxidative burst potential was increased at 2 h, maximum at 6 h, and normal at 24 h after reperfusion, but not in sham rats. CD18 expression was similar in all groups. There was a significant temporal correlation between the "priming state" of the circulating neutrophil, defined as the product of the neutrophil number times oxidative burst, and lung leak. CONCLUSIONS The neutrophil "priming state" may allow the clinician to better predict those patients at greatest risk for multiple organ failure.
Statistical Inverse Estimation in Hilbert Scales

The recovery of signals from indirect measurements, blurred by random noise, is considered under the assumption that prior knowledge regarding the smoothness of the signal is avialable. For greater flexibility the general problem is embedded in an abstract Hilbert scale. In the applications Sobolev scales are used. For the construction of estimators we employ preconditioning along with regularized operator inversion in the appropriate inner product, where the operator is bounded but not necessarily compact. A lower bound to certain minimax rates is included, and it is shown that in generic examples the proposed estimators attain the asymptotic minimax rate. Examples include errors-in-variables (deconvolution) and indirect nonparametric regression. Special instances of the latter are estimation of the source term in a differential equation and the estimation of the initial state in the heat equation.
A Cubic Framework for the Chief Data Officer: Succeeding in a World of Big Data

A new breed of executive, the Chief Data Officer (CDO), has stepped onto the stage, emerging as a key leader in the organization. To help readers understand this development, we provide a three-dimensional framework that describes the role of the CDO. The three dimensions include: (1) collaboration direction (inward vs. outward), (2) data space (traditional data vs. big data), and (3) value impact (service vs. strategy). We illustrate the framework with examples from early adopters and provide recommendations to help organizations assess and strategize the establishment of their own CDOs.
Gonadotropin receptors of the ovine ovarian follicle during follicular growth and atresia.

The binding of [125 Il-labeled human follicle stimulating hormone ([12511 -FSH) and chorionic gonadotropin ((12111 -hCG) to intact ovine follicles was studied in vitro as a function of follicular diameter and stage of morphological atresia. Histological confirmation of the atretic classification was established and the incidence of atresia in those follicles studied was variable and directly related to follicular diameter (P<0.0i). The binding of [‘251)-hFSH and (‘251)-hCG to theca was relatively constant when compared to the change in granulosa binding that was associated with increased follicular diameter or stage of atresia. When studied without regard to the stage of atresia, the binding of (12511 -hFSH to granulosa cells decreased and that of [12511 -hCG increased with increased follicular diameter. These changes were thought to reflect changes in the relative incidence of atresia within each size group rather than decreased binding per se. Subsequent analysis of [12511 -labeled gonadotropin binding to granuhosa cells as a function of both folhicular diameter and stage of atresia simultaneously indicated that the extent of (‘2511-hFSH binding was determined solely by stage of atresia rather than follicular diameter (P<0.05). Conversely, while 152511 -hCG binding was decreased by increased atresia, the overall extent of binding was determined by follicular diameter (P<0.01). It is concluded that macroscopic assessment of follicular atresia in ovarian follicular populations is directly related to follicular diameter. In addition, the ability of granulosa cells to bind (12511. labeled gonadotropins in vitro varies as a function of follicular diameter and stage of atresia.