Miracle-dz/UniFAR-FTUs huggingface dataset:
Combined covariance model for non-coding RNA gene finding

The use of covariance models in finding non-coding RNA gene members in genome sequence databases has been shown quite effective in many studies. However, it has a significant drawback, which is the very large computational burden. A combined covariance model is proposed to reduce the search complexity when a genome sequence is searched for more than one ncRNA gene family. The covariance models that are combined are selected using a hierarchical clustering algorithm. This study shows that when a small number of original covariance models are combined, the combined covariance model can find members from all original ncRNA families thus successfully reducing the search time.
Calpains Mediate Integrin Attachment Complex Maintenance of Adult Muscle in Caenorhabditis elegans

Two components of integrin containing attachment complexes, UNC-97/PINCH and UNC-112/MIG-2/Kindlin-2, were recently identified as negative regulators of muscle protein degradation and as having decreased mRNA levels in response to spaceflight. Integrin complexes transmit force between the inside and outside of muscle cells and signal changes in muscle size in response to force and, perhaps, disuse. We therefore investigated the effects of acute decreases in expression of the genes encoding these multi-protein complexes. We find that in fully developed adult Caenorhabditis elegans muscle, RNAi against genes encoding core, and peripheral, members of these complexes induces protein degradation, myofibrillar and mitochondrial dystrophies, and a movement defect. Genetic disruption of Z-line– or M-line–specific complex members is sufficient to induce these defects. We confirmed that defects occur in temperature-sensitive mutants for two of the genes: unc-52, which encodes the extra-cellular ligand Perlecan, and unc-112, which encodes the intracellular component Kindlin-2. These results demonstrate that integrin containing attachment complexes, as a whole, are required for proper maintenance of adult muscle. These defects, and collapse of arrayed attachment complexes into ball like structures, are blocked when DIM-1 levels are reduced. Degradation is also blocked by RNAi or drugs targeting calpains, implying that disruption of integrin containing complexes results in calpain activation. In wild-type animals, either during development or in adults, RNAi against calpain genes results in integrin muscle attachment disruptions and consequent sub-cellular defects. These results demonstrate that calpains are required for proper assembly and maintenance of integrin attachment complexes. Taken together our data provide in vivo evidence that a calpain-based molecular repair mechanism exists for dealing with attachment complex disruption in adult muscle. Since C. elegans lacks satellite cells, this mechanism is intrinsic to the muscles and raises the question if such a mechanism also exists in higher metazoans.
A bipartite graph model for associating images and text

The joint modeling of image and textual content is even more important now because of the the availability of large databases of image-rich web pages and the tagging phenomenon. Much of the current work focused on one-way association (image to text or tags). The association is often captured by building a model with hidden variables. In this paper, we propose a simple model based on random walks on bipartite graphs for joint modeling of image and textual content. We show its effectiveness for several tasks— automatic image annotation, tag association, tag localization, and spurious tag detection. Such random walk models are useful for other tasks such as web search.
A qualitative systematic overview of the measurement properties of functional walk tests used in the cardiorespiratory domain.

OBJECTIVE To perform a qualitative systematic overview of the measurement properties of the most commonly utilized walk tests in the cardiorespiratory domain: the 2-min walk test (2MWT), 6-min walk test (6MWT), 12-min walk test (12MWT), self-paced walk test (SPWT), and shuttle walk test (SWT). DATA SOURCES MEDLINE (1966 to January 2000) and CINAHL (1982 to December 1999) electronic databases were searched. Bibliographies of the retrieved articles were reviewed. STUDY SELECTION Clinical trials and observational studies were included if they reported data on the validity, reliability, interpretability, or responsiveness of the 2MWT, 6MWT, 12MWT, SPWT, or SWT. Only studies conducted on patients with cardiac and/or respiratory involvement were included. RESULTS Fifty-two studies examining measurement properties of the various walk tests were found: 5 studies on the 2MWT, 29 studies on the 6MWT, 13 studies on the 12MWT, 6 studies on the SPWT, and 4 studies on the SWT. Measurement properties were most strongly demonstrated for the 6MWT. Correlations of 6MWT distance and maximal oxygen consumption ranged from 0.51 to 0.90. A change in distance walked of at least 54 m was found to be clinically significant for the 6MWT. Reliability was shown to be optimized when the administration of walk tests was standardized and at least two practice walks were performed. Patients with increased likelihood of postoperative complications, hospitalization, and death were identified by analysis of distance walked. CONCLUSIONS Measurement properties of the 6MWT have been the most extensively researched and established. In addition, the 6MWT is easy to administer, better tolerated, and more reflective of activities of daily living than the other walk tests. Therefore, the 6MWT is currently the test of choice when using a functional walk test for clinical or research purposes.
Athene in academe: women mentoring women in the academy 1

Increasingly, adult educators are expressing interest in the activity of mentoring in the academy. The literature discusses it as primarily a positive adult learner/adult teacher connection. This is evident in its discussion of the structural and personal relationships and of the multiple outcomes associated with the process. A feminist critique of mentoring, however, reveals that these analyses are androcentric. They ignore women academics’ unique location as both ‘same’ and ‘other’ within patriarchal academe. Theoretical consideration of this location yields new understandings of the potentials and problematics of the role of women as mentors. 1Selected portions of this paper were presented at a joint conference of the Australian Association for Research in Education and the New Zealand Association for Research in Education, 22‐26 November, 1992, Geelong, Australia.
Pancreatic cancer treatment and research: an international expert panel discussion.

BACKGROUND Pancreatic cancer has proven extremely challenging to treat. A collaborative effort is needed to advance research and improve treatment. An expert conference was conducted to elicit perspectives regarding the current treatment and future research of pancreatic cancer. METHODS The conference comprised an international panel of experts representing five European countries and the United States. RESULTS Adjuvant radiotherapy is used more frequently in the United States than in Europe. In locally advanced disease, there is now more emphasis on early chemotherapy in both Europe and the United States. In metastatic disease, combination chemotherapy is commonly used in Europe and the United States. This varies by country. Advancing pancreatic research will require improving biorepositories and developing a roadmap to prioritize therapeutic targets in different models. Small randomized phase II trials of both non-selected and enriched patient populations will help identify activity of new agents. Phase III trials should only be initiated in appropriate patients based on strong clinical and biological signals. Developing drugs in the adjuvant setting may be preferable to eliminate some of the challenges of drug development in the advanced disease setting. CONCLUSION Progress in research combined with encouraging improvements from the past offer hope for the future of pancreatic cancer patients.
Aging in a Foreign Country: Voices of Iranian Women Aging in Canada

ABSTRACT Older Iranian women, who immigrated to Canada in later adulthood, experience unique issues as they age. In order to better understand this experience, in-depth, personal and semi-structured interviews were conducted with five immigrant/refugee Iranian women who immigrated to Canada in their later life. Analysis revealed that although each woman's story conveyed individual differences and idiosyncrasies, all the stories highlighted the critical interweaving of the aging experience and the immigration experience: neither experience could be understood in isolation of the other; each aspect gave meaning to the other experience. Two interrelated messages dominated the women's stories: first was the importance of each woman's immigration story for grounding her experience of the aging process in Canada. Second, each woman's personal story suggested that the immigration experiences were accorded priority for accounting for her experiences in Canada. Specifically, cultural identity (i.e., social class, education, religious affiliation and immigration status) offered a valuable cloak for overshadowing the force of the aging process and the aging process emerged as an elusive force that lurked in the background without ever being fully acknowledged or given power in their lives. The implications of these findings in relation to theory development on intersectionality and professional practice are discussed.
Impact of the isolation medium for detection of carbapenemase-producing Enterobacteriaceae using an updated version of the Carba NP test.

Carbapenem resistance in Enterobacteriaceae is now emerging worldwide at an alarming rate, causing both nosocomial and now communityacquired infections (Nordmann et al., 2012a). A variety of carbapenemases have been reported in Enterobacteriaceae such as KPC (Ambler class A), metallo-blactamases of VIM-, IMPand NDM-type (Ambler class B), and OXA-48-types (Ambler class D). Thus, an efficient strategy for detection of carbapenemase producers is becoming critical for the determination of appropriate therapeutic schemes and the implementation of infection control measures (Nordmann & Poirel, 2013). Recently, the Carba NP test has been developed for rapid identification of carbapenemase production in Enterobacteriaceae (Nordmann et al., 2012b). Here, we further improve and evaluate the ability of the Carba NP test to detect carbapenemase producers among Enterobacteriaceae recovered from various commercial media (selective, non-selective and screening media) used in clinical situations.
The numerical simulation of internal three-dimensional flow in the axial-flow fire-fighting fan

Axial-flow axial fan is used as fire fighting parts in the axial-flow pneumatic extinguisher. The shape of axial impeller is the key factor affecting the internal flow field structure of fire-fighting fan, outlet Total pressure and flow velocity. In order to understand the flow pattern of axial-flow fire-fighting fan thoroughly, according to N-S equations and k-ɛ turbulence model, the internal three-dimensional viscous flow field of axial-flow fire-fighting fan was numerically simulated and many internal flow details, rules and performance parameters of axial-flow fan under the design working conditions was obtained. Numerical analysis shows that under the design working conditions, gas takes parallel flow from inlet and helically outflows from outlet as a whole, vortex generates at the blade tip area, some gas have reversed flow and lead to loss. The simulation results provide a theoretical basis for performance improvements of axial-flow fire-fighting fan.
Software Reconfigurable State-of-the-Art Communication Suite for Fighter Aircraft

Communication systems are considered as one of the major requirements for the current and next generation fighter aircrafts to complete a mission successfully. Efficient net-centric warfare and situational awareness can be achieved with modernized communication system and high-end sensors. The conventional communication systems available consist of individual systems for each functionality. In such cases, the failure of one system leads to failure of the functionality of that system and the mission has to be completed without that system. Hence there is an urge to develop a state-of-the-art on-flight software reconfigurable communication system to provide better redundancy, successful completion of mission and efficient utilization of systems on-board for fighter aircraft. In this paper, the functionality of all the on-board communication systems is explained and the design of a state-of-the-art software re-configurable communication suite is proposed for fighter aircrafts. The highlight of this architecture is that the hardware resources are shared between the systems and incase of failure of one system, the other system shall be reconfigured on-flight to take up the functionality of the failed system. The software architecture employs software code reusability for easy debugging and code verification. The proposed system is based on the concept of Software Defined Radio (SDR) and the functionality is extended from hand-held radio to entire communication system of the aircraft.
A physical layer secure wireless communication scheme with partial CSI for high speed railway

The high speed railway wireless communication system is quite different from public wireless communication system, because the service is train control message, which are closely related to the safety of train transportation. Thus it has much higher requirements for the safety and reliability. In this paper, secrecy capacity and outage probability at the high speed railway scenario with traditional MIMO and beamforming schemes are analyzed. The analytic results show that MIMO scheme can not meet the safety requirements and the beamforming scheme is also helpless while the eavesdropper is close to eNodeB. In order to guarantee the transmission safety of train control messages, a physical layer secure scheme with artificial noise (AN) is proposed for high speed railway communication system. In this proposed scheme, beamforming and AN transmitting directions are adjusted accordingly with the onboard legitimate receiver's channel state information (CSI) and eavesdropper's partial CSI to degrade the eavesdropper while maximize the system secrecy capacity. Simulation results demonstrate the proposed scheme decreases the outage probability under the secrecy capacity constraint, and can meet the safety communication requirements.
Observer based adaptive output feedback tracking control of robot manipulators

In this paper, we propose an observer based adaptive output feedback (OFB) tracking controller for rigid-link robot manipulators. Specifically, we used a model independent observer in conjuction with a desired compensation adaptation law (DCAL) to remove the link velocity dependency of the controller and achieved asymptotic stability of the observer-controller couple despite the uncertainties associated with the system dynamics. Lyapunov based arguments are utilized to illustrate the stability of the proposed controller. Simulation results are included to demonstrate the performance of observer-controller couple.
The Russian Press in the Post-Soviet Era: a case study of Izvestia

The progress of the Russian press in the late Soviet and post-Soviet eras can be described (with apologies to Vladimir Lenin) as "two steps forward, one step back". The flowering of glasnost (openness) under Mikhail Gorbachev led to a "golden age" of Soviet journalism, including an explosion of new publications and a lifting of nearly all state restrictions on journalists' professional activities. However, the collapse of the USSR and the onset of material crisis in 1991/92 quickly produced a winnowing of the press and a retrenchment on the part of surviving publications. At the same time, powerful new forces--especially oligarchs and regional and leaders--arose to vie with the state for influence over post-Soviet media. This paper explores the trajectory of one of the leading newspapers of the Soviet and post-Soviet period, Izvestia , in the light of these broader trends. While Izvestia emerged from the ashes of Soviet communism with formal control over its material plant and journalistic collective, it was soon subjected to a tug-of-war between powerful actors determined to control its destiny--first the communist-dominated Duma (parliament), and then large corporations and business oligarchs. The struggle led, in 1997, to the dismissal of the paper's editor, Oleg Golembiovsky, and the departure of many staff to form Novye Izvestia ( New Izvestia )--though this publication, too, was also unwilling or unable to avoid the temptations of a close alliance with one of the leading oligarchs, Boris Berezovsky. In the conclusion, the findings are placed in the broader comparative context of Russian and (briefly) global media in transition, based on the author's research into the process of media liberalization and transition worldwide.
Semantics directed program execution monitoring

Abstract Monitoring semantics is a formal model of program execution which captures ‘monitoring activity’ as found in profilers, tracers, debuggers, etc. Beyond its theoretical interest, this formalism provides a new methodology for implementing a large family of source-level monitoring activities for sequential deterministic programming languages. In this article we explore the use of monitoring semantics in the specification and implementation of a variety of monitors: profilers, tracers, collecting interpreters, and, most importantly, interactive source-level debuggers. Although we consider such monitors only for (both strict and non-strict) functional languages, the methodology extends easily to imperative languages, since it begins with a continuation semantics specification. In addition, using standard partial evaluation techniques as an optimization strategy, we show that the methodology forms a practical basis for building real monitors. Our system can be optimized at two levels of specialization: specializing the interpreter with respect to a monitor specification automatically yields an instrumented interpreter; further specializing this instrumented interpreter with respect to a source program yields an instrumented program, i.e. one in which the extra code to perform monitoring has been automatically embedded into the program.
An Interactive Care System Based on a Depth Image and EEG for Aged Patients with Dementia

Due to the limitations of the body movement and functional decline of the aged with dementia, they can hardly make an efficient communication with nurses by language and gesture language like a normal person. In order to improve the efficiency in the healthcare communication, an intelligent interactive care system is proposed in this paper based on a multimodal deep neural network (DNN). The input vector of the DNN includes motion and mental features and was extracted from a depth image and electroencephalogram that were acquired by Kinect and OpenBCI, respectively. Experimental results show that the proposed algorithm simplified the process of the recognition and achieved 96.5% and 96.4%, respectively, for the shuffled dataset and 90.9% and 92.6%, respectively, for the continuous dataset in terms of accuracy and recall rate.
Soccer specific aerobic endurance training

Background: In professional soccer, a significant amount of training time is used to improve players' aerobic capacity. However, it is not known whether soccer specific training fulfils the criterion of effective endurance training to improve maximal oxygen uptake, namely an exercise intensity of 90–95% of maximal heart rate in periods of three to eight minutes. Objective: To determine whether ball dribbling and small group play are appropriate activities for interval training, and whether heart rate in soccer specific training is a valid measure of actual work intensity. Methods: Six well trained first division soccer players took part in the study. To test whether soccer specific training was effective interval training, players ran in a specially designed dribbling track, as well as participating in small group play (five a side). Laboratory tests were carried out to establish the relation between heart rate and oxygen uptake while running on a treadmill. Corresponding measurements were made on the soccer field using a portable system for measuring oxygen uptake. Results: Exercise intensity during small group play was 91.3% of maximal heart rate or 84.5% of maximal oxygen uptake. Corresponding values using a dribbling track were 93.5% and 91.7%. No higher heart rate was observed during soccer training. Conclusions: Soccer specific exercise using ball dribbling or small group play may be performed as aerobic interval training. Heart rate monitoring during soccer specific exercise is a valid indicator of actual exercise intensity.
Frequency Domain Real Time Digital Image Watermarking

The present paper puts forward real time implementation of an algorithm for Watermarking and the results obtained using a Frequency domain approach. The paper emphasizes an Adaptive Frequency domain watermarking approach in real time, demonstrating robustness against intentional or unintentional attacks on the watermarked image. This is achieved by modifying the middle frequency coefficients. Since the image is analyzed and modified in the frequency domain the changes made are difficult to perceive. The algorithm steps and special consideration regarding the real-time implementation on TI’s TMS320C6711 DSP are presented. Applications of watermarking process in real time are also described.
A History of the Surrey Institution

The Surrey Institution, Blackfriars, founded in 1808, was, after the Royal Institution and London Institution, the third establishment in London aimed at fostering and disseminating scientific, technical, and literary knowledge and understanding among a wider public. The Institution offered its proprietors and subscribers the use of an extensive reference library and reading rooms and, most importantly, the opportunity to attend courses of lectures on scientific, technological, and other subjects. Though popular in approach, the lectures conformed to high educational standards and were delivered by recognized authorities in their fields. In the Surrey Institution's celebrated auditorium, the 'Rotunda', there appeared over the years such notable scientists as Accum, Thomson, and Gurney on chemistry, Millington, Mason Good, and Woodward on natural philosophy, Bakewell on geology, and Shaw on natural history; literature was brilliantlyrepresented by Coleridge and Hazlitt. During its relatively brief life-span (1808-23)-cut short by financial stringencies-the Surrey Institution provided access to scientific knowledge and thinking to a wide and appreciative audience. As a meeting place fo scientists and men of business with mercantile and manufacturing interests, it performed an important function in cross-fertilizing and reinforcing ideas on innovation and enterprise against the background of the ongoing Industrial Revolution. The present article attempts to supply a historical account, so far lacking, of the foundation, activities and achievements of this significant Institution of the metropolis.