Miracle-dz/UniFAR-FTUs huggingface dataset:
A Graph-Based Random Access Protocol for Crowded Massive MIMO Systems

To resolve intra-cell pilot collision in crowded massive multiple-input multiple-output systems, a new pilot random access protocol, called strongest-user collision resolution combined graph-based pilots access (SUCR-GBPA), is proposed. This protocol allows all failed user equipments (UEs) to randomly select a pilot from the pilots that are not selected by any UE in the initial step. By exploiting the characteristic that the channel responses between UEs and the base station are invariant within the coherence time, a bipartite graph is established where active UEs and selected pilots are considered variable nodes and factor nodes, respectively. Based on this bipartite graph, the successive interference cancellation algorithm is employed to estimate the channel response of each UE. Finally, utilizing the and-or tree principle, we analyze the performance of the proposed SUCR-GBPA protocol, including the maximum number of the tolerable active UEs, the minimum number of the required pilots, uplink throughput, and the mean-square-error performance of the SUCR-GBPA channel estimation. Simulation results demonstrate that, compared with the SUCR protocol, the proposed SUCR-GBPA protocol significantly improves the uplink throughput and provides accurate estimation on the channel response at the same time.
Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme

Macrophage‐generated oxygen‐ and nitrogen‐reactive species control the development of Mycobacterium tuberculosis infection in the host. Mycobacterium tuberculosis ‘truncated hemoglobin’ N (trHbN) has been related to nitric oxide (NO) detoxification, in response to macrophage nitrosative stress, during the bacterium latent infection stage. The three‐dimensional structure of oxygenated trHbN, solved at 1.9 Å resolution, displays the two‐over‐two α‐helical sandwich fold recently characterized in two homologous truncated hemoglobins, featuring an extra N‐terminal α‐helix and homodimeric assembly. In the absence of a polar distal E7 residue, the O2 heme ligand is stabilized by two hydrogen bonds to TyrB10(33). Strikingly, ligand diffusion to the heme in trHbN may occur via an apolar tunnel/cavity system extending for ∼28 Å through the protein matrix, connecting the heme distal cavity to two distinct protein surface sites. This unique structural feature appears to be conserved in several homologous truncated hemoglobins. It is proposed that in trHbN, heme Fe/O2 stereochemistry and the protein matrix tunnel may promote O2/NO chemistry in vivo, as a M.tuberculosis defense mechanism against macrophage nitrosative stress.
Sustainability, Resource Efficiency and Competitiveness. An Assessment of Resource Efficiency Policies in the European Union. Bruges European Economic Research Papers (BEER) 32/2015.

Addressing high and volatile natural resource prices, uncertain supply prospects, reindustrialization attempts and environmental damages related to resource use, resource efficiency has evolved into a highly debated proposal among academia, policy makers, firms and international financial institutions (IFIs). In 2011, the European Union (EU) declared resource efficiency as one of its seven flagship initiatives in its Europe 2020 strategy. This paper contributes to the discussions by assessing its key initiative, the Roadmap to a Resource Efficient Europe (EC 2011 571), following two streams of evaluation. In a first step, resource efficiency is linked to two theoretical frameworks regarding sustainability, (i) the sustainability triangle (consisting of economic, social and ecological dimensions) and (ii) balanced sustainability (combining weak and strong sustainability). Subsequently, both sustainability frameworks are used to assess to which degree the Roadmap follows the concept of sustainability. It can be concluded that it partially respects the sustainability triangle as well as balanced sustainability, primarily lacking a social dimension. In a second step, following Steger and Bleischwitz (2009), the impact of resource efficiency on competitiveness as advocated in the Roadmap is empirically evaluated. Using an Arellano–Bond dynamic panel data model reveals no robust impact of resource efficiency on competiveness in the EU between 2004 and 2009 – a puzzling result. Further empirical research and enhanced data availability are needed to better understand the impacts of resource efficiency on competitiveness on the macroeconomic, microeconomic and industry level. In that regard, strengthening the methodologies of resource indicators seem essential. Last but certainly not least, political will is required to achieve the transition of the EU-economy into a resource efficient future.
Anti-Cancer Properties of Heterotrigona itama sp. Honey Via Induction of Apoptosis in Malignant Glioma Cells

Background There has been increasing evidence showing that stingless bee honey exhibits anti-oxidant, anti-inflammatory and anti-cancer properties. Pharmacologically-active components in honey such as flavonoids and phenolic constituents are known to contribute to its medicinal benefits. To the best of our knowledge, this is the first study on evaluating anti-cancer effects of locally-produced Malaysian stingless bee honey from Heterotrigona itama sp. on malignant glioma cells. Methods Proliferation and apoptosis studies of U-87 MG cells following stingless bee honey treatment were carried out using MTS assay and acridine orange/propidium iodide dual staining, respectively. Results Results demonstrated time and dose-dependent cytotoxicity using 0.625%, 1.25% and 10% stingless bee honey (P < 0.05). IC50 values were calculated using cells treated with 10% stingless bee honey. It was also observed that 10% stingless bee honey induced nuclear shrinkage, chromatin condensation and nucleus fragmentation, indicating that cellular changes were consistent with the apoptotic characteristics of the cells. Conclusion These data provide a good basis for further evaluation of the medicinal properties of stingless bee honey from Heterotrigona itama sp. This source of honey may serve as a potential therapy for malignant glioma.
Distinct functions for Bmp signaling in lip and palate fusion in mice

Previous work suggested that cleft lip with or without cleft palate (CL/P) is genetically distinct from isolated cleft secondary palate (CP). Mutations in the Bmp target gene Msx1 in families with both forms of orofacial clefting has implicated Bmp signaling in both pathways. To dissect the function of Bmp signaling in orofacial clefting, we conditionally inactivated the type 1 Bmp receptor Bmpr1a in the facial primordia, using the Nestin cre transgenic line. Nestin cre; Bmpr1a mutants had completely penetrant, bilateral CL/P with arrested tooth formation. The cleft secondary palate of Nestin cre; Bmpr1a mutant embryos was associated with diminished cell proliferation in maxillary process mesenchyme and defective anterior posterior patterning. By contrast, we observed elevated apoptosis in the fusing region of the Nestin cre; Bmpr1a mutant medial nasal process. Moreover, conditional inactivation of the Bmp4 gene using the Nestin cre transgenic line resulted in isolated cleft lip. Our data uncover a Bmp4-Bmpr1a genetic pathway that functions in lip fusion, and reveal that Bmp signaling has distinct roles in lip and palate fusion.
Complex Admittance Detection of Horizontal Oil-Water Two-Phase Flows Using a Capacitance Sensor

Capacitance sensors have been widely used in the measurement of two-phase flows encountered in industrial processes due to their advantages of non-intrusiveness and quick response. In this paper, an equivalent circuit model of a concave capacitance sensor for stratified oil-water flow is established. Based on this model, the effects of the excitation signal frequency on the fluid admittance are investigated to optimize the geometric structure of the concave capacitance sensor. A capacitance sensor system is designed to simultaneously detect the real (Re) and the imaginary (Im) parts of the oil-water complex admittance. The Re and Im response signals of the capacitance sensor are collected in the dynamic experiment of horizontal oil-water flows. The influences of the flow pattern and the excitation frequency on the measurement of fluid complex admittance are experimentally explored.
A Programmable Load/Store Unit on C-based Hardware Design for FPGA

This paper proposes to introduce a programmable load/store unit (LSU) to C-based hardware design for an FPGA. The LSU provides flexible memory access methods that can hide memory access latency for hardware modules generated by a high-level synthesis tool. The hardware module with the LSU can treat efficiently not only simple streaming accesses but also sophisticated accesses such as image processing. The LSU is evaluated using two case studies. The result shows that the LSU can significantly reduce the burden of designing the dedicated memory access circuits and the hardware modules with the LSU achieve a speedup of 16.5 and 27.3 times compared with an embedded processor.
Seasonal variation of leaf wax n-alkane production and δ2H values from the evergreen oak tree, Quercus agrifolia

In order to understand the timing of leaf wax synthesis in higher plants, we analysed the variability in leaf wax n-alkane concentration, composition (expressed as average chain length (ACL)), and δ2Hwax values as well as plant source water δ2H values (xylem and leaf water) in the evergreen tree Quercus agrifolia over a period of 9 months, beginning with leaf flush. We identified three distinct periods of leaf development with the first month following leaf flush being characterized by de novo synthesis and possibly removal of n-alkanes. During the following 3 months, n-alkane concentrations increased sevenfold and δ2Hwax and ACL values increased, suggesting this period was the major leaf wax n-alkane formation period. During the remaining 4 months of the experiment, stable values suggest cessation of leaf wax n-alkane formation. We find that n-alkane synthesis in Q. agrifolia takes place over 4 months, substantially longer than that observed for deciduous trees.
Delivery of biotinylated IGF-1 with biotinylated self-assembling peptides combined with bone marrow stem cell transplantation promotes cell therapy for myocardial infarction

Cell therapy is a promising approach for cardiac repair. The aim of the present study was to determine the feasibility of using biotinylated insulin-like growth factor 1 (IGF-1) with biotinylated self-assembling peptides (tethered IGF-1) combined with bone marrow stem cells (BMSCs) transplantation for the treatment of heart failure. Tethered IGF-1 was synthesized and its effect on H9c2 cells was analyzed. Reverse transcription-quantitative polymerase chain reaction and western blot assays demonstrated that tethered IGF-1 did not significantly affect the expression and phosphorylation of AKT, whereas it significantly increased the expression of cardiac troponin T (P<0.01). A rabbit myocardial infarction model was constructed and rabbits were divided into four groups: Control group (no treatment), group 1 (G1; BMSC transplantation), group 2 (G2; BMSCs + non-biotinylated IGF-1) and group 3 (G3; BMSCs + tethered IGF-1). At 4 weeks after modeling, cardiac tissues were obtained for analysis. In the control group, myocardial fibers were disordered, a large number of inflammatory cells infiltrated the cardiac tissues, and apoptosis occurred in ~50% of cells. However, in G1, G2 and G3, muscle cells were well ordered, and a lesser degree of myocardial degeneration and inflammatory cell infiltration was observed. Compared with the control group, the apoptosis rates of myocardial cells in G1-G3 were significantly decreased (P<0.01). Furthermore, compared with G1 and G2, tissue morphology was improved in G3and the number of apoptotic myocardial cells was significantly decreased (P<0.01). These results suggest that treatment with tethered IGF-1 + BMSCs significantly suppresses cell apoptosis and induces the expression of cardiac maturation proteins. These findings provide a novel insight into how the delivery of tethered IGF-1 with BMSCs could potentially enhance the prognosis of patients with heart failure treatment.
Advancing Alternative Analysis: Integration of Decision Science

Background: Decision analysis—a systematic approach to solving complex problems—offers tools and frameworks to support decision making that are increasingly being applied to environmental challenges. Alternatives analysis is a method used in regulation and product design to identify, compare, and evaluate the safety and viability of potential substitutes for hazardous chemicals. Objectives: We assessed whether decision science may assist the alternatives analysis decision maker in comparing alternatives across a range of metrics. Methods: A workshop was convened that included representatives from government, academia, business, and civil society and included experts in toxicology, decision science, alternatives assessment, engineering, and law and policy. Participants were divided into two groups and were prompted with targeted questions. Throughout the workshop, the groups periodically came together in plenary sessions to reflect on other groups’ findings. Results: We concluded that the further incorporation of decision science into alternatives analysis would advance the ability of companies and regulators to select alternatives to harmful ingredients and would also advance the science of decision analysis. Conclusions: We advance four recommendations: a) engaging the systematic development and evaluation of decision approaches and tools; b) using case studies to advance the integration of decision analysis into alternatives analysis; c) supporting transdisciplinary research; and d) supporting education and outreach efforts. https://doi.org/10.1289/EHP483
Epigen is induced during the interleukin-13–stimulated cell proliferation in murine primary airway epithelial cells

ABSTRACT Airway remodeling in bronchial asthma is characterized by epithelial detachment and proliferation, subepithelial fibrosis, increased smooth muscle mass, and goblet cell hyperplasia. These features are mediated by T-helper type 2 (Th2) cytokines including interleukin (IL)-13. However, the direct effects of IL-13 on the functions of airway epithelial cells are not fully understood. Murine primary airway epithelial (MPAE) cells were cultured in an air-liquid interface (ALI) culture system. AG1478, a specific inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, was used to examine whether EGFR was involved in the IL-13–stimulated proliferation of MPAE cells. The expressions of EGFR ligands were investigated by reverse transcriptase–polymerase chain reaction, Western blotting, and immunohistochemical analyses. The cell counting in cross-sections and [3H]thymidine incorporation assays revealed a significant increase in the number of MPAE cells cultured with IL-13 compared with a phosphate-buffered saline (PBS) control. AG1478 abolished the IL-13–stimulated proliferation of MPAE cells. The expression of epigen, one of the EGFR ligands, was enhanced in MPAE cells cultured with IL-13. The findings suggest that EGFR is involved in the IL-13–stimulated proliferation of MPAE cells, and that epigen is important for the proliferation process in airway remodeling.
Comparison of H.265 and VP9 coding efficiency for full HDTV and ultra HDTV applications

This paper presents a performance comparison of the two modern video coding standards H.265/HEVC and VP9. For such comparison, the latest available versions of codecs for encoding were used. Comparison is provided by set of objective quality metrics. Comparing of coding efficiency is evaluated for Full HDTV and also for Ultra HDTV. Results indicate a dominance of HEVC encoding algorithm in comparison to VP9 if bit rates are set to higher values. In low bitrates results are both codecs very balanced with small dominance of VP9.
Samp1 is a component of TAN lines and is required for nuclear movement

The position of the nucleus is regulated in different developmental stages and cellular events. During polarization, the nucleus moves away from the future leading edge and this movement is required for proper cell migration. Nuclear movement requires the LINC complex components nesprin-2G and SUN2, which form transmembrane actin-associated nuclear (TAN) lines at the nuclear envelope. Here we show that the nuclear envelope protein Samp1 (NET5) is involved in nuclear movement during fibroblast polarization and migration. Moreover, we demonstrate that Samp1 is a component of TAN lines that contain nesprin-2G and SUN2. Finally, Samp1 associates with SUN2 and lamin A/C, and the presence of Samp1 at the nuclear envelope requires lamin A/C. These results support a role for Samp1 in the association between the LINC complex and lamins during nuclear movement.
Adaptive Rule Update Method in Complex Event Process

Complex Event Process is a real-time data process technology based on the event process rule or event pattern, which was used to extract high level knowledge from a big amount of data, such as sensor data, stock data, etc. However, those rules, which are dened by the experts, are generally inaccuracy and static. And it is difcult to adapt to environmental changes. In this paper, to solve the problems, an adaptive rule updating method is proposed to adapt environment changing. Firstly, deleting error and unnecessary data in preprocess for improving the processing efciency. And detecting abnormal rule, which is produced by monitoring the changes of Page Hinckley test(PHT) value. Secondly, updating the condition value of rule by adaptive cluster-based rule constraint method, and increasing a new better attribute by computing the effective value. However, rule constraint updating and new attribute increasing is depended on a given threshold representing the data size which is related to the current rule. If the variable value of data is bigger than the given threshold, it will compute the effective value of attribute, otherwise, the cluster-based adaptive constraint updating method is employing. This paper proposed an adaptive rule updating-based complex event processing framework for verifying the feasibility of the method.
Pretreatment Liver Injury Predicts Poor Prognosis of DLBCL Patients

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of lymphoma, with different clinical manifestation and prognosis. The International Prognostic Index (IPI), an index designed during the prerituximab era for aggressive lymphoma, showed variable values in the prediction of patient clinical outcomes. The aim of this study was to analyze the prognostic value and causes of pretreatment liver injury in 363 de novo DLBCL patients in our institution. Pretreatment liver impairment, commonly detected in lymphoma patients, showed significant association with poor outcomes and increased serum inflammatory cytokines in DLBCL patients but had no relation to hepatitis B virus replication nor lymphomatous hepatic infiltration. Multivariate analysis revealed that liver dysfunction, advanced Ann Arbor stage, and elevated lactate dehydrogenase (LDH) were independent adverse prognostic factors of both PFS and OS. Accordingly, a new liver-IPI prognostic model was designed by adding liver injury as an important factor in determining IPI score. Based on Kaplan-Meier curves for PFS and OS, the liver-IPI showed better stratification in DLBCL patients than either the IPI or the revised IPI in survival prediction.
A Reliability Allocation Method for Mechanical Product Based on Meta-Action

For a long time, the machinery's reliability allocation methods have followed the electronics', and thus all of the interactions among moving components and parts in machines are neglected. In fact, the allocated results are not reasonable for mechanical products; even the allocation granularity is not appropriate to guide the reliability design. To overcome these problems, this paper proposes an allocation method based on meta-action. By using the function-movement-action method, we decompose the mechanical product into meta-actions. An action is used as the basic unit of reliability control, and all the parts contributing to the action are treated as a whole. The interactions of the parts which contribute to the same action are treated as the internal forces of meta-actions, and others are considered as the interactions between meta-actions by the consideration of common parts in different units. An illustrative example shows the proposed method makes the results more reasonable and more convenient to guide mechanical product designs.
Protein Kinase C and Acute Respiratory Distress Syndrome

ABSTRACT The acute respiratory distress syndrome (ARDS) is a major public health problem and a leading source of morbidity in intensive care units. Lung tissue in patients with ARDS is characterized by inflammation, with exuberant neutrophil infiltration, activation, and degranulation that is thought to initiate tissue injury through the release of proteases and oxygen radicals. Treatment of ARDS is supportive primarily because the underlying pathophysiology is poorly understood. This gap in knowledge must be addressed to identify urgently needed therapies. Recent research efforts in anti-inflammatory drug development have focused on identifying common control points in multiple signaling pathways. The protein kinase C (PKC) serine-threonine kinases are master regulators of proinflammatory signaling hubs, making them attractive therapeutic targets. Pharmacological inhibition of broad-spectrum PKC activity and, more importantly, of specific PKC isoforms (as well as deletion of PKCs in mice) exerts protective effects in various experimental models of lung injury. Furthermore, PKC isoforms have been implicated in inflammatory processes that may be involved in the pathophysiologic changes that result in ARDS, including activation of innate immune and endothelial cells, neutrophil trafficking to the lung, regulation of alveolar epithelial barrier functions, and control of neutrophil proinflammatory and prosurvival signaling. This review focuses on the mechanistic involvement of PKC isoforms in the pathogenesis of ARDS and highlights the potential of developing new therapeutic paradigms based on the selective inhibition (or activation) of specific PKC isoforms.
Infection trials in pigs with a human isolate of Brucella (isolate 02/611 ‘marine mammal type’)

Abstract AIM: To determine if pigs could support infection of a human Brucella isolate (Brucella 02/611) from New Zealand, and to study seroconversion to this isolate using a competitive ELISA. METHODS: Ten weaner piglets were challenged with 4.8 × 108 cfu of organisms by the oral and ocular routes. Culture was attempted on blood samples taken prior to challenge, and 4, 7, 9, 11, 14, 21 and 28 days post-challenge, and on tissue samples taken at the termination of the trial, 1 month after challenge. Sera were analysed for antibody using an ELISA. For reference comparison, similar trials were conducted in two pigs using an isolate of Brucella suis biovar 1, and two pigs using an isolate of B. suis biovar 3. RESULTS: Brucella 02/611 organisms were re-isolated from one lymph node each from three pigs; all other samples were negative. Low and transient antibody titres were detected using a competitive ELISA in three pigs, two of which were culture-negative. Organisms of B. suis reference strains were re-isolated from multiple samples from each of the four animals. CONCLUSION: Brucella 02/611 does not seem to replicate readily in pigs. It is unlikely that pigs were the original maintenance hosts for Brucella 02/611.