Miracle-dz/UniFAR-FTUs huggingface dataset:
A dynamic magnetic shift method to increase nanoparticle concentration in cancer metastases: a feasibility study using simulations on autopsy specimens

A nanoparticle delivery system termed dynamic magnetic shift (DMS) has the potential to more effectively treat metastatic cancer by equilibrating therapeutic magnetic nanoparticles throughout tumors. To evaluate the feasibility of DMS, histological liver sections from autopsy cases of women who died from breast neoplasms were studied to measure vessel number, size, and spatial distribution in both metastatic tumors and normal tissue. Consistent with prior studies, normal tissue had a higher vascular density with a vessel-to-nuclei ratio of 0.48 ± 0.14 (n = 1000), whereas tumor tissue had a ratio of 0.13 ± 0.07 (n = 1000). For tumors, distances from cells to their nearest blood vessel were larger (average 43.8 μm, maximum 287 μm, n ≈ 5500) than normal cells (average 5.3 μm, maximum 67.8 μm, n ≈ 5500), implying that systemically delivered nanoparticles diffusing from vessels into surrounding tissue would preferentially dose healthy instead of cancerous cells. Numerical simulations of magnetically driven particle transport based on the autopsy data indicate that DMS would correct the problem by increasing nanoparticle levels in hypovascular regions of metastases to that of normal tissue, elevating the time-averaged concentration delivered to the tumor for magnetic actuation versus diffusion alone by 1.86-fold, and increasing the maximum concentration over time by 1.89-fold. Thus, DMS may prove useful in facilitating therapeutic nanoparticles to reach poorly vascularized regions of metastatic tumors that are not accessed by diffusion alone.
The 'State Tradition' in Australia: Reassessing an Earlier View

This article seeks to revive interest in an Australian 'state tradition' that has been undergoing continuous development since the first European settlements in the late 1700s and early 1800s. Recent attempts to redefine such a tradition miss many of the foundational elements. There has been a tendency to locate the beginnings in the federal 'settlement' of 1901, and to see as outdated and irrelevant anything that happened before the current mood of marketising and privatising came to dominate our notions of political and economic correctness. Major changes have of course occurred in the nature of Australian statehood over the years, and they will continue to occur. However an understanding of the tradition restated in this article remains important for several reasons: because that tradition has furnished the foundations of so many of our national institutions; because it provides a standard against which the recent changes can be assessed; and because it will continue to influence and inform challenges to today's economic-rationalist/NPM (New Public Management) paradigm. Such challenges will seek to take us further forward, not backward, but in a style that is inclusive rather than divisive.
Ectogenesis and Mother as Machine

This article addresses the oft-neglected nexus between the mother and the machine, specifically in relation to the notion of ectogenesis (that is, conception, gestation and birth outside the maternal body). After a discussion of the technologies and the discourses of ectogenesis as symptomatic of what I call an ectogenetic desire, I move on to critically consider the work of Smith-Windsor on her own maternal experience with an incubator. This is followed by an evaluation of feminist writings on reproductive technologies, leading to a discussion of why the critical dichotomy between the maternal body and the machine needs to be reevaluated, to develop the possibility of a different ethics of/for the maternal body.
Brand personality complementatity : its effects on evaluations of extremely incongruent extensions

Prior research on brand extension has provided little evidence on enhancing the evaluation of extremely incongruent extension. Adopting the theoretical framework of schema congruity theory, the author posits that evaluations can be improved if brand personality impressions of both parent brand and extension are complementary. The author coins this as the brand personality complementarity (BPC) principle. Prior to examining BPC effect, cultural-specific brand personality scale was developed to identify universal and indigenous brand personality dimensions. The reason is BPC requires a reliable and valid brand personality scale in order to detect its effect. Following successful identification of the cultural-specific brand personality scale, a total of three experimental studies were done to investigate BPC effect. Specifically, one experimental study identified complementary levels amongst brand personality dimensions, whereas two experimental studies investigated the moderating effect of BPC. Findings from the scale development study reveal that Malaysian brand personality (MBP) scale is a second higher-order factor reflected by first higher-order factors of sophistication, youth, competence, and sincerity. Most importantly, findings from the experimental studies revealed; 1) different BPC levels amongst all possible pairs of MBP dimensions, 2) significant interaction effect of brand extension congruity x BPC, and 3) significant mediation effect of complementarity resolution. Specific findings indicated that when iv text-based stimuli were used to form brand personality impression, even low BPC level improves the evaluations of extremely incongruent extension. However, when visualbased stimuli were used, low BPC level worsen the extension evaluation compared those of the control condition (i.e. without brand personality impression). Implications for both academician and practitioner are discussed.
Mathematical model and computer software for EMT analysis in HV and MV grids

The paper presents a computer program, intended for calculations of electromagnetic transients, related to short-circuit and earth faults in distribution grids. Appropriate mathematical models of the main power system devices are developed with the instantaneous currents and voltages. The authors propose a universal structural approach for combining all device models into a single mathematical state-space description. This approach allows easy extension of the models library. The paper also proposes three methods for the solution of the state-space model. The presented comparative calculations prove the adequate modelling and show the advantages of the developed computer program.
A Prospective Randomized Study Comparing Division of the Pedicle of Modified Hughes Flaps at Two or Four Weeks

Purpose To compare the incidence of upper and lower eyelid malposition or other complications when the pedicle in modified Hughes flap repair of the lower eyelid is divided at 2 versus 4 weeks. Methods A prospective randomized study. Data were collected on patient age and sex, horizontal tumor dimension, upper and lower eyelid position before surgery and 3 months after division of the pedicle, and any complications. Results Complete data from 60 patients were collected, with 32 patients in the 2-week group and 28 patients in the 4-week group. The two groups were not significantly different in terms of sex, age, or tumor dimensions. In the 2-week group, the upper eyelid was within 1 mm of its preoperative position at 3 months in 25 of 32 patients (78.1%) and in 26 of 28 (92.8%) in the 4-week group. The lower eyelid was within 1 mm of its normal position in 27 of 32 patients in the 2-week group (84.4%) versus 25 of 28 (89.3%) in the 4-week group. Statistical analysis showed no significant difference between the 2- and 4-week groups for upper and lower eyelid position at 3 months. Other complications were uncommon and evenly spread between the two groups. Conclusions A modified Hughes flap pedicle may be divided at 2 weeks with no increased incidence in upper or lower eyelid malposition or other complication.
The Effect of Writing Task and Task Conditions on Colombian EFL Learners' Language Use

This classroom study examines whether English L2 writers’ language use differs depending on the writing task (operationalized as paragraph type), and task conditions (operationalized as individual or collaborative writing). The texts written by English L2 university students in Colombia (N = 26) in response to problem/ solution and cause/effect writing tasks were compared in terms of analytic ratings, use of target grammatical clauses, and accuracy. Approximately half of the students wrote individually while the other half collaborated in pairs. Results indicated that the writing task was a significant factor, with cause/effect paragraphs rated higher and having more target clauses than the problem/solution paragraphs. Task condition was also a significant factor, with collaborative texts more accurate than individual texts. Implications for L2 writing pedagogy are highlighted.
Organ Bağışına Yönelik Tutumların Planlı Davranış Kuramı Çerçevesinde İncelenmesi

In the present study, attitudes toward organ donation in transplant patients and their relatives, non-transplant patients (cancer, heart disease etc.) and healthy people were analyzed on the basis of the Theory of Planned Behavior (TPB Ajzen, 1985). Data was collected by the personal information form and the attitudes toward organ donation questionnaire based on the TPB. The questionnaire was developed by using the conceptual and methodological considerations as recommended by Ajzen (2002). Transplant patients and their relatives got higher scores compared to other two groups in the TPB’s antecedents of attitude, subjective norm, perceived behavioral control and intention. At the end of the study, participants were asked if they would agree to sign an organ donation form. Participants who accepted to fill out an organ donation form were found to have more positive attitudes toward organ donation, perceived more control over behavior, and felt more social pressure compared to the ones who did not agree to fill out the form. TPB assumes that the attitude, subjective norm, perceived behavioral control and intention are the antecedents of behavior. The contribution of these antecedents on the prediction of organ donation behavior was analyzed by structural equation modeling. In the structural analysis of the data collected on the basis of TPB, it was observed that perceived behavioral control mediated the relationships between attitude-intention, and subjective norm-intention.
HYPOXIA-INDUCED ALTERATION OF MITOCHONDRIAL GENES IN CARDIOMYOCYTES: ROLE OF Bnip3 AND Pdk1

The hypoxic conditions induced by reduced blood flow decreases oxygen availability in target tissues. Cellular hypoxia leads to mitochondrial dysfunction, decreased energy production, and increased production of reactive oxygen species. To determine the alteration in expression of mitochondrial genes after hypoxia in cardiomyocytes, we developed a rodent mitochondrial gene chip (RoMitoChip). The chip had 1088 probe sets including 46 probe sets representing 37 mouse mitochondrial DNA transcripts and the remaining probe sets representing mouse nuclear genes contributing to the mitochondrial structure and function. Mouse cardiomyocytes isolated from neonatal C57BL/6 mice that were subjected to hypoxia (1% oxygen) for different time intervals demonstrated a dichotomy in the expression profile of tRNA and mRNA transcripts. We report a total of 483 signature genes that were altered by hypoxia in the cardiac myocytes and related to mitochondrial structure and function. This includes 23 transcripts on mitochondrial DNA. Pathway analysis demonstrated predominant changes in the expression of genes involved in oxidative phosphorylation, glucose and fatty acid metabolism, and apoptosis. The most upregulated genes after 24 h of hypoxia included hypoxia-inducible factor 1, &agr; subunit, inducible genes Bnip3, Pdk1, and Aldoc. Whereas Bnip3 is important in the cardiomyocyte death pathway, Pdk1 enzyme is critical in conserving mitochondrial function by diverting metabolic intermediates to glycolysis. This study identifies the participation of two important pathways, cell death and glycolytic, and two key proteins, Bnip3 and Pdk1, playing critical roles in these pathways in cardiomyocytes after severe hypoxia.
Echinonectin: a new embryonic substrate adhesion protein

An extracellular matrix molecule has been purified from sea urchin (Lytechinus variegatus) embryos. Based on its functional properties and on its origin, this glycoprotein has been given the name "echinonectin. " Echinonectin is a 230-kD dimer with a unique bow tie shape when viewed by electron microscopy. The molecule is 12 nm long, 8 nm wide at the ends, and narrows to approximately 4 nm at the middle. It is composed of two 116-kD U-shaped subunits that are attached to each other by disulfide bonds at their respective apices. Polyclonal antibodies were used to localize echinonectin in paraffin-embedded, sectioned specimens by indirect immunofluorescence. The protein is stored in vesicles or granules in unfertilized eggs, is released after fertilization, and later becomes localized on the apical surface of ectoderm cells in the embryo. When used as a substrate in a quantitative in vitro assay, echinonectin is highly effective as an adhesive substrate for dissociated embryonic cells. Because of the quantity, pattern of appearance, distribution, and adhesive characteristics of this protein, we suggest that echinonectin serves as a substrate adhesion molecule during sea urchin development.
Stable adaptive fuzzy control of nonlinear systems

The author develops a direct adaptive fuzzy controller which does not require an accurate mathematical model of the system under control, is capable of incorporating fuzzy control rules directly into the controllers, and guarantees the global stability of the resulting closed-loop system in the sense that all signals involved are uniformly bounded. The specific formula of the bounds is provided so that controller designers can determine the bounds based on their requirements. The direct adaptive fuzzy controller is used to regulate an unstable system to the origin. Simulation results show that the direct adaptive fuzzy controller can perform successful control without using any fuzzy control rules. After incorporating some fuzzy control rules into the controllers the adaptation speed became much faster. The author also showed explicitly how the supervisory control forced the state to be within the constraint set and how the adaptive fuzzy controller learned to regain control. <<ETX>>
[Application of serum protein profiling in diagnosis, prognosis and evaluation of curative effect of pancreatic adenocarcinoma].

OBJECTIVE To establish decision tree and logistic regression classification models for diagnosing pancreatic adenocarcinoma (PaCa) and for screening serum biomarkers related to evaluation of different stages and curative effects. METHODS Serum samples obtained from subjects with pancreatic adenocarcinoma (n = 58) and normal pancreas (n = 51) were applied to strong anion exchange chromatography (SAX2) chips for protein profiling by SELDI-TOF-MS to screen multiple serum biomarkers. Biomarker Wizard software and several statistical methods including algorithm of decision tree, logistic regression and ROC curves were used to construct the decision tree or logistic regression classification models. RESULTS Average of 61 mass peaks were detected at the molecular range of 2000-30,000, ten decision trees with the highest cross validation rate were chosen to construct the classification models, which can differentiate PaCa from normal pancreas with a sensitivity of 83.3% and a specificity of 100%. Logistic regression was used to achieve the AUC (0.976 +/- 0.011, P < 0.001) with a sensitivity of 77.6% - 91.4% and a specificity of 92.2% - 100%. Six mass peaks were combined by logistic regression to achieve the AUC 0.897 +/- 0.054, 0.978 +/- 0.021 and 0.792 +/- 0.107 (P < 0.05) in the three groups (patients at stage I and II, stage II and III, stage III and IV). One mass peak (M/Z 4,016) was screened (P < 0.05) significantly between the preoperative and postoperative PaCa samples and the intensity decreased weeks after operation. CONCLUSION Decision tree and logistic regression classification models of the mass peaks screened by SELDI-TOF-MS serum profiling can be used to differentiate pancreatic adenocarcinoma from normal pancreas, and is superior to CA 199. The detected mass peaks are helpful for the evaluation of curative effect and prognosis of pancreatic adenocarcinoma.
Investigation on visible light communication system using OLED with dimming support

In this paper, a visible light communications (VLC) system prototype using organic light emitting diode (OLED) with dimming support was realized and tested. Frequency response and driving range of OLED were measured and discussed. Considering practical applications of OLED, variable pulse position modulation (VPPM) signal was used to support data transmission under dimming condition. Our prototype was able to transmit up to 85 kbps data rate using an OLED with only 7 kHz 3 dB modulation bandwidth. For the target BER=10-3 with FEC, the luminous flux could be varied within 5-8 lm.
Impact of Informing Overweight Individuals about the Role of Genetics in Obesity: An Online Experimental Study

Background/Aims: Increasing public awareness of obesity genetics could have beneficial or harmful effects on overweight individuals. This study examined the impact of genetic information on weight-related cognitions as well as interest in personalized genetic information about obesity among overweight individuals. Methods: Online survey respondents (n = 655) were randomly assigned to read either genetic, gene-environment, or nongenetic obesity causal information. Fifty-two percent of the participants were female, 82.4% were White, 45% had an annual income of USD <40,000, and the mean BMI was 32.5. Internalized weight stigma was measured using the Weight Bias Internalization Scale. Results: Participants in the genetic and gene-environment conditions were more likely to believe genetics increase obesity risk than participants in the nongenetic condition (both p < 0.05); however, they did not differ regarding internalized weight stigma. Sixty-four percent of the participants expressed interest in receiving personalized genetic information about their obesity risk. Conclusion: Dissemination of information about obesity genetics may have neither a beneficial nor a harmful impact on how overweight individuals perceive themselves. Some overweight individuals may be interested in receiving personalized genetic information. The actual effects of obesity genetic information being incorporated into public health messages and of personalized genetic information on obesity prevention and treatment interventions remain to be seen.
Fab forms

We address the problem of allowing casual users to customize parametric models while maintaining their valid state as 3D-printable functional objects. We define Fab Form as any design representation that lends itself to interactive customization by a novice user, while remaining valid and manufacturable. We propose a method to achieve these Fab Form requirements for general parametric designs tagged with a general set of automated validity tests and a small number of parameters exposed to the casual user. Our solution separates Fab Form evaluation into a precomputation stage and a runtime stage. Parts of the geometry and design validity (such as manufacturability) are evaluated and stored in the precomputation stage by adaptively sampling the design space. At runtime the remainder of the evaluation is performed. This allows interactive navigation in the valid regions of the design space using an automatically generated Web user interface (UI). We evaluate our approach by converting several parametric models into corresponding Fab Forms.
Torcetrapib Does Not Reduce Atherosclerosis Beyond Atorvastatin and Induces More Proinflammatory Lesions Than Atorvastatin

Background— Although cholesteryl ester transfer protein (CETP) inhibition is regarded as a promising strategy to reduce atherosclerosis by increasing high-density lipoprotein cholesterol, the CETP inhibitor torcetrapib given in addition to atorvastatin had no effect on atherosclerosis and even increased cardiovascular death in the recent Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events trial. Therefore, we evaluated the antiatherogenic potential and adverse effects of torcetrapib in humanized APOE*3-Leiden.CETP (E3L.CETP) mice. Methods and Results— E3L.CETP mice were fed a cholesterol-rich diet without drugs or with torcetrapib (12 mg · kg−1 · d−1), atorvastatin (2.8 mg · kg−1 · d−1), or both for 14 weeks. Torcetrapib decreased CETP activity in both the absence and presence of atorvastatin (−74% and −73%, respectively; P<0.001). Torcetrapib decreased plasma cholesterol (−20%; P<0.01), albeit to a lesser extent than atorvastatin (−42%; P<0.001) or the combination of torcetrapib and atorvastatin (−40%; P<0.001). Torcetrapib increased high-density lipoprotein cholesterol in the absence (30%) and presence (34%) of atorvastatin. Torcetrapib and atorvastatin alone reduced atherosclerotic lesion size (−43% and −46%; P<0.05), but combination therapy did not reduce atherosclerosis compared with atorvastatin alone. Remarkably, compared with atorvastatin, torcetrapib enhanced monocyte recruitment and expression of monocyte chemoattractant protein-1 and resulted in lesions of a more inflammatory phenotype, as reflected by an increased macrophage content and reduced collagen content. Conclusions— CETP inhibition by torcetrapib per se reduces atherosclerotic lesion size but does not enhance the antiatherogenic potential of atorvastatin. However, compared with atorvastatin, torcetrapib introduces lesions of a less stable phenotype.
Inventaire abrégé de la dépression de Beck (13 items). Etude de la validité concurrente avec les échelles de Hamilton et de ralentissement de Widlöcher.

: The present study on 50 depressed subjects (Research Diagnostic Criteria of Feighner) has shown on the one hand a weak correlation between the shortened Beck Depression Inventory (BDI) and the Hamilton Depression Rating Scale and on the other hand of the shortened Beck Depression Inventory and the Widlocher Retardation Rating Scale. Both correlations do not differ significantly.
The Transition to Adulthood among Japanese Youths

This study examines courtship and activities leading to courtship among Japanese youths. Courtship is an important topic because it influences the chances of eventual marriage. The analyses of the Japanese Life Course Panel Survey show 42 percent of young unmarried people without a partner actively sought a dating partner during the past year. The most popular activity among both men and women was asking friends for introductions. Men tended to engage in partner-search activities when they were highly educated, had a full-time job, intended to get married, and had opportunities to meet the opposite sex. Among women, the intention to marry was the key factor in predicting the likelihood of partner-search activities, in addition to family assets. The effect of the partner search on the chances of finding a partner appears to be greatest for the men and women least likely to engage in partner searches.