Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonmuscle myosin IIA facilitates vesicle trafficking for MG53‐mediated cell membrane repair

Repair of injury to the plasma membrane is an essential mechanism for maintenance of cellular homeostasis and integrity that involves coordinated movement of intracellular vesicles to membrane injury sites to facilitate patch formation. We have previously identified MG53 as an essential component of the cell membrane repair machinery. In order for MG53 and intracellular vesicles to translocate to membrane injury sites, motor proteins must be involved. Here, we show that nonmuscle myosin type IIA (NM‐IIA) interacts with MG53 to regulate vesicle trafficking during cell membrane repair. In cells that are deficient for NM‐IIA expression, MG53 cannot translocate to acute injury sites, whereas rescue of NM‐IIA expression in these cells can restore MG53‐mediated membrane repair. Compromised cell membrane repair is observed in cells with RNAi‐mediated knockdown of NM‐IIA expression, or following pharmacological alteration of NM‐IIA motor function. Together, our data reveal NM‐IIA as a key cytoskeleton motor protein that facilitates vesicle trafficking during MG53‐mediated cell membrane repair. —Lin, P., Zhu, H. , Cai, C. , Wang, X. , Cao, C. , Xiao, R. , Pan, Z. , Weisleder, N. , Takeshima, H. , Ma, J. Nonmuscle myosin IIA facilitates vesicle trafficking for MG53‐mediated cell membrane repair. FASEB J. 26, 1875‐1883 (2012). www.fasebj. org
A true fundic diverticulum of the gallbladder

Journal of Gastroenterology and Hepatology 21 (2006) 1221–1226 © 2006 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd Letters to the Editor Blackwell Publishing AsiaMelbourne, AustraliaJGHJournal of Gastroenterology and Hepatology0815-93192006 Blackwell Publishing Asia Pty Ltd July 200621712211226Letter to the Editor Letters to the EditorLetters to the Editor LETTERS TO THE EDITOR
Electric field effects on human spinal injury: Is there a basis in the in vitro studies?

An important basis for the clinical application of small DC electric current to mammalian spinal injury is the responses of neurons in culture to applied electric fields. Our recent finding that zebrafish neurons were unresponsive to applied fields prompted us to critically examine previous results. We conclude that compelling evidence for neuronal guidance and directional stimulation of growth toward either the cathode or anode in an electric field exists only for cultured Xenopus neurons, and not for any mammalian neurons. No basis for the reported success in treating spinal injury exists in the in vitro studies, and considerable research will be required if the conditions of field application in mammalian spinal injury are to be optimized. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2008
Cooperative spin crossover behavior in cyanide-bridged Fe(II)-M(II) bimetallic 3D Hofmann-like networks (M = Ni, Pd, and Pt).

The three-dimensional polymeric compounds [Fe(pz)M(CN)4]·nH2O (pz = pyrazine; M = Ni(II), Pd(II), and Pt(II)) have been synthesized and characterized. They undergo strong cooperative spin transitions, large hysteresis loops, and dramatic color changes upon spin conversion. The two-dimensional homologues [Fe(py)2M(CN)4] (py = pyridine; M = Ni(II), Pd(II), and Pt(II)) also have been synthesized and characterized. In the latter case cooperativity is smaller than in the tri-dimensional derivatives, and consequently narrower hysteresis loops were observed.
Cyclin A in Predicting Cervical Intraepithelial Neoplasia, High-Risk Human Papillomavirus Infections and Their Outcome inWomenScreened inThree New Independent States of the Former Soviet Union

Background: The growth-controlling functions of the highrisk human papillomaviruses (HPV) depend on their ability to interact with several cellular proteins, including the key regulatory proteins of the cell cycle. We have examined the value of cell cycle regulatory proteins as predictors of the intermediate end point markers in cervical carcinogenesis: (a) grade of cervical intraepithelial neoplasia (CIN), (b) highrisk HPV type, (c) clearance/persistence of high-risk HPV, and (d) disease outcome in women participating in a multicenter follow-up study in three New Independent States countries. Methods: Totally, 232 biopsy samples tested high-risk HPVpositive and/or Papanicolaou smear – positive women were immunohistochemically stained for the following cell cycle markers: p105, p107, p130, E2F4, p21 CIP1/WAF1/SDI1 , cyclin A, and Ki-67. In addition, apoptotic index (AI) and mitotic index (MI) were determined in HE 95% confidence interval, 1.01-1.18; P = 0.021), exceeding the predictive power of CIN grade and high-grade squamous intraepithelial lesion Papanicolaou smears. None of these markers provided any useful predictive information as to the clinical and virological outcomes during the follow-up. Highly significant correlations (P = 0.0001) were found between AI and MI as well as between MI and cyclin A, Ki-67 and p21 CIP1/WAF1/SDI1 , Ki-67 and cyclin A, and p21 CIP1/WAF1/SDI1 and cyclin A followed by that between p105 and cyclin A (P = 0.001) and p105 and p130 (P = 0.002). Conclusions: All tested factors related to cell cycle were increased, but only MI and cyclin A was an independent predictor of CIN3 and high-risk HPV carriage, respectively. (Cancer Epidemiol Biomarkers Prev 2006;15(7):1250– 6)
Organizational Innovation and Human Resource Practice: A View of Strategic Human Resource Bundling

There are many literatures focusing on relationships between human resource practices and organizational performance improvement and competitive advantages, but there are few on relationships between human resource practices and organizational innovation. Based on 74 samples, we find though organizations pay many attentions to human resource practices, but individual human resource practice has no significant effect on organizational innovation, while systematical, strategic, human resource bundling practices has significant effect on organizational innovation.
Thread Assignment in Multicore/Multithreaded Processors: A Statistical Approach

The introduction of multicore/multithreaded processors, comprised of a large number of hardware contexts (virtual CPUs) that share resources at multiple levels, has made process scheduling, in particular assignment of running threads to available hardware contexts, an important aspect of system performance. Nevertheless, thread assignment of applications running on state-of-the art processors is an NP-complete problem. Over the years, numerous studies have proposed heuristic-based algorithms for thread assignment. Since the thread assignment problem is intractable, it is in general impossible to know the performance of the optimal assignment, so the room for improvement of a given algorithm is also unknown. It is therefore hard to decide whether to invest more effort and time to improve an algorithm that may already be close to optimal. In this paper, we present a statistical approach to the thread assignment problem. First, we present a method that predicts the performance of the optimal thread assignment, based on the observed performance of each thread assignment in a random sample. The method is based on Extreme Value Theory (EVT), a branch of statistics that analyses extreme deviations from the population mean. We also propose sample pruning, a method that significantly reduces the time required to apply the statistical method by reducing the number of candidate solutions that need to be measured. Finally, we show that, if no suitable heuristic-based algorithm is available, a sample of several thousand random thread assignments is enough to obtain, with high confidence, an assignment with performance close to optimal. The presented approach is architecture and application independent, and it can be used to address the thread assignment problem in various domains. It is especially well suited for systems in which the workload seldom changes. An example is network systems, which typically provide a constant set of services that are known in advance, with network applications performing a similar processing algorithm for each packet in the system. In this paper, we validate our methods with an industrial case study for a set of multithreaded network applications on an UltraSPARC T2 processor. This article is an extension of our previous work [44], which was published in Proceedings of 17th International Conference on Architectural Support for Programming Languages and Operating Systems (ASPLOS-2012).
Psychological Characteristics of Adults With IDDM: Comparison of Patients in Poor and Good Glycemic Control

This study was conducted to evaluate selected psychosocial characteristics of contrasting groups of patients with insulin-dependent diabetes mellitus (IDDM), i.e., patients with persistently poor versus good glycemic control. Patients with chronic poor control reported feeling physically best at higher blood glucose levels than patients with good control. They also reported a higher threshold for physical symptoms caused by hyperglycemia without any difference in threshold for hypoglycemic symptoms. No differences between groups were found in level of diabetes knowledge, self-esteem, or psychiatric symptomatology. This study suggests that poorly controlled adult patients have underlying perceptions of hyperglycemic symptoms and physical well-being that distinguish them from patients with well-controlled diabetes. The design of this study does not allow for determination of the causal direction in this relationship. Although these patient reports about glycemic and physical symptoms may be post hoc justifications or unreliable beliefs, they also may be accurate perceptions of physical symptom experiences and therefore could influence their self-care activities with resulting chronic problems in glycemic control. Further research is needed to assess the validity of these observations and their possible role in long-term regulation of glycemia.
Active Idleness Scheduler with Simulated Annealing

Abstract In this paper we address the problem of optimizing the Time Window Controller (TW-Controller). This controller was first introduced in 2001 as a supervising mechanism for distributed scheduling of multiclass queuing networks with the objective of stabilizing those networks. It was then also shown that the TW-Controller possesses the ability to improve performance of stable networks. We revise the controller and present a series of formal results concerning its main properties and features. Then, we propose to use Simulated Annealing on a simulation-based optimization approach and present numerical results that demonstrate the controller's ability to improve performance over any given scheduling policy.
X-DART: Blending Dropout and Pruning for Efficient Learning to Rank

In this paper we propose X-DART, a new Learning to Rank algorithm focusing on the training of robust and compact ranking models. Motivated from the observation that the last trees of MART models impact the prediction of only a few instances of the training set, we borrow from the DART algorithm the dropout strategy consisting in temporarily dropping some of the trees from the ensemble while new weak learners are trained. However, differently from this algorithm we drop permanently these trees on the basis of smart choices driven by accuracy measured on the validation set. Experiments conducted on publicly available datasets shows that X-DART outperforms DART in training models providing the same effectiveness by employing up to 40% less trees.
Clinical Severity Scores in Gastrointestinal Graft-Versus-Host Disease

Background The clinical prognosis of gastrointestinal (GI) graft-versus-host disease (GvHD) is based on either a clinical staging system or histological or endoscopic findings. How these different scores correlate with each other and which have the greater impact on transplantation outcomes is, however, not clear. Methods Clinical, pathological, and endoscopic findings of the upper GI tract on 201 patients who underwent allogeneic hematopoietic stem cell transplantation were reviewed. The association between clinical, histological, and endoscopy grading was assessed by Kendall correlation coefficient. The agreement between grading systems was evaluated by kappa statistics. Factors associated with survival or steroid resistance were analyzed by proportional hazard models. Results At disease onset, no strong association was found between pathological and clinical grade at disease onset (&tgr;=0.034, P=0.6). In contrast, endoscopy score and clinical grades were strongly associated (&tgr;=0.37, P<0.001). The Kappa concordance coefficient (0.20) between histological and endoscopy scores was poor. However, by multivariate analysis all three scores significantly predicted survival rates Conclusions Clinical, histological, and endoscopic scores poorly correlated with each other when estimated at the GI-GvHD onset. However, all three severe initial scores independently predict poor outcome. Of interest, clinical and endoscopic scores predict resistance to steroids while pathological does not.
Formation of Atomically Flat Silver Films on GaAs with a "Silver Mean" Quasi Periodicity

A flat epitaxial silver film on a gallium arsenide [GaAs(110)] surface was synthesized in a two-step process. Deposition of a critical thickness of silver at low temperature led to the formation of a dense nanocluster film. Upon annealing, all atoms rearranged themselves into an atomically flat film. This silver film has a close-packed (111) structure modulated by a “silver mean” quasi-periodic sequence. The ability to grow such epitaxial overlayers of metals on semiconductors enables the testing of theoretical models and provides a connection between metal and semiconductor technologies.
Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor.

BACKGROUND AND AIMS Mutations in either adenosine triphosphate- binding cassette (ABC) half-transporter G5 or G8 cause sitosterolemia. It has been proposed that ABCG5/ABCG8 heterodimers mediate secretion of plant sterols and cholesterol by hepatocytes into bile and their efflux from enterocytes into the intestinal lumen. METHODS To test whether deficiency of ABCG5 alone is sufficient to induce sitosterolemia, Abcg5-null mice were generated and characterized with respect to sterol metabolism. RESULTS Abcg5 deficiency was associated with strongly elevated plasma levels of beta-sitosterol (37-fold) and campesterol (7.7-fold) as well as reduced plasma cholesterol concentrations (-40%). Retention of orally administered [(3)H]beta-sitosterol in the intestinal wall (+550%) and plasma (+640%) was higher in Abcg5-null mice than in wild-type controls. Surprisingly, high plasma beta-sitosterol and campesterol concentrations were even further elevated in Abcg5-null mice on treatment with the synthetic LXR agonist T0901317 (0.015% dietary supplementation, 10 days), whereas these concentrations were reduced by approximately 75% in wild-type mice. Both cholesterol and phospholipid concentrations in gallbladder bile were decreased, but, unexpectedly, cholesterol/phospholipid ratios were unchanged in the absence of Abcg5 and increased in both genotypes on LXR activation. Hepatic expression of Abcg8 was reduced by about 35% in Abcg5-deficient mice when compared with controls. No compensatory overexpression of other ABC transporters potentially involved in hepatic cholesterol trafficking was observed on messenger RNA level. CONCLUSIONS Our data show that disruption of the Abcg5 gene alone is sufficient to cause hyperabsorption of dietary plant sterols and sitosterolemia in mice, whereas the ability to secrete cholesterol into bile is maintained.
Performance Analysis of a MIMO Indoor Infrared Communication System under Ambient Light Noise

Based on a Bell Laboratories layered space-time (BLAST) technique, a room configuration model of the indoor multiple-input multiple-output (MIMO) infrared diffuse channels is established, and all the surface elements in the room are assumed to act as ambient light noise sources. The performance of two transmitters and two receivers MIMO system is compared against single-input single-output (SISO) system with the same total transmitter power. Numerical results show that different position leads to different bit error rate (BER) due to the variety of received ambient optical power. We also show that the MIMO system can achieve better bit error rate (BER) performance than the SISO system in the proposed diffuse channels model.
Analysis of Electrode Shift Effects on Wavelet Features Embedded in a Myoelectric Pattern Recognition System

Myoelectric pattern recognition systems can translate muscle contractions into prosthesis commands; however, the lack of long-term robustness of such systems has resulted in low acceptability. Specifically, socket misalignment may cause disturbances related to electrodes shifting from their original recording location, which affects the myoelectric signals (MES) and produce degradation of the classification performance. In this work, the impact of such disturbances on wavelet features extracted from MES was evaluated in terms of classification accuracy. Additionally, two principal component analysis frameworks were studied to reduce the wavelet feature set. MES from seven able-body subjects and one subject with congenital transradial limb loss were studied. The electrode shifts were artificially introduced by recording signals during six sessions for each subject. A small drop in classification accuracy from 93.8% (no disturbances) to 88.3% (with disturbances) indicated that wavelet features were able to adapt to the variability introduced by electrode shift disturbances. The classification performance of the reduced feature set was significantly lower than the performance of the full wavelet feature set. The results observed in this study suggest that the effect of electrode shift disturbances on the MES can potentially be mitigated by using wavelet features embedded in a pattern recognition system.
First‐trimester fetal cardiac examination using spatiotemporal image correlation, tomographic ultrasound and color Doppler imaging for the diagnosis of complex congenital heart disease in high‐risk patients

A four‐dimensional (4D) fetal echocardiographic technique utilizing spatiotemporal image correlation, tomographic ultrasound imaging display (STIC‐TUI echo) and color Doppler has previously been shown to be effective in displaying the examination planes constituting the extended cardiac examination. The aim of this study was to evaluate the performance of this first‐trimester STIC‐TUI echo technique in identifying complex congenital heart disease (CHD) in high‐risk pregnancies.
Are Movement Artifacts in Magnetic Resonance Imaging a Real Problem?—A Narrative Review

Movement artifacts compromise image quality and may interfere with interpretation, especially in magnetic resonance imaging (MRI) applications with low signal-to-noise ratio such as functional MRI or diffusion tensor imaging, and when imaging small lesions. High image resolution has high sensitivity to motion artifacts and often prolongs scan time that again aggravates movement artifacts. During the scan fast imaging techniques and sequences, optimal receiver coils, careful patient positioning, and instruction may minimize movement artifacts. Physiological noise sources are motion from respiration, flow and pulse coupled to cardiac cycles, from the swallowing reflex and small spontaneous head movements. Par example, in resting-state functional MRI spontaneous neuronal activity adds 1–2% of signal change, even under optimal conditions signal contributions from physiological noise remain a considerable fraction hereof. Movement tracking during imaging may allow for prospective correction or postprocessing steps separating signal and noise.
Search Based Software Testing for Android

This talk will cover some of the history of search based software testing, charting some of the milestones in the intellectual development of the subject. The talk concludes with the current work by Mao, Harman and Jia on SBST for the Android platform, which saw the three of them recruited from the start-up Majicke to Facebook, where there are now working on test automation.
Relative potencies of polychlorinated dibenzo‐p‐dioxin, dibenzofuran, and biphenyl congeners to induce cytochrome P4501A mRNA in a zebrafish liver cell line

Induction of cytochrome P4501A (CYP1A) mRNA by polychlorinated dibenzo‐ p‐dioxin (PCDD), polychlorinated dibenzofuran (PCDF), and polychlorinated biphenyl (PCB) congeners was measured in a zebrafish liver (ZF‐L) cell line. The ZF‐L cells were far less sensitive to PCDD, PCDF, and PCB congeners than were other fish cell lines. The 2,3,7,8‐PCDDs, 2,3,7,8‐PCDFs, and PCB 126 caused dose‐related induction. All other PCBs tested, including other coplanar as well as ortho‐substituted congeners, were ineffective at inducing CYP1A. The potency of each congener that gave a response, relative to 2,3,7,8‐tetrachlo‐rodibenzo‐p‐dioxin, was determined. The ZF‐L cell–derived relative potency values (REPs) are similar to other in vitro REPs in that the ZF‐L cell–derived REPs are generally higher than those derived from in vivo models. Furthermore, the ZF‐L cell–derived REPs are generally within fivefold of REPs determined in a variety of rainbow trout systems when the same endpoint in the same tissue are compared. Analysis of these data indicates that REPs based on molecular and biochemical responses in sensitive and insensitive species are similar, but overestimate relative in vivo toxicity in the rainbow trout. The ZF‐L cell–derived REPs expand the database of REPs, providing additional information that will be useful in quantifying the uncertainty associated with applying consensus fish‐specific toxic equivalency factors in ecological risk assessment.
Three Saxo-Norman Tenements in Durham City

A WELL-PRESERVED SEQUENCE of craftsmen's premises and their associated refuse was found in three tenements off Saddler Street in Durham City. The earliest occupation took place in the second half of the 10th century and a tenement area had been defined within a few decades. The destruction of the occupied tenement by fire took place sometime in the second half of the 11th century and was contemporary with the collapse of the local late Saxon pottery trade. This was followed by the development of the two adjacent properties and the fencing of the boundaries between them. The tenements were occupied by shoemakers and cobblers from their earliest days and their economic interdependence with the community is shown to be high. There was no special evidence for Scandinavian influence in a culture that otherwise resembled in many respects that of Anglo-Scandinavian York. The recorded sequence ended in the early 13th century.
Order reduction of complex systems described by TSK fuzzy models based on singular perturbations method

This article deals with the concept of order reduction of linear complex systems described by TSK fuzzy models. The use of singular perturbations technique for process modelling and the choice of Benrejeb arrow form characteristic matrix provide the decoupling of dynamics of linear systems in the continuous and discrete case. An original contribution is to apply nonconventional TSK fuzzy approach on a direct current motor in order, on one hand, to highlight the order reduction of this system presented locally in the form of linear models and, on the other hand, to show the efficiency of the proposed approaches.