Miracle-dz/UniFAR-FTUs huggingface dataset:
Designing embroidered electrodes for wearable surface electromyography

Muscle activity monitoring or Electromyography (EMG) is useful in gait analysis, injury prevention, computer or robot interfaces and assisting patients with communication difficulties. However, EMG is typically invasive or obtrusive, expensive and difficult to use for untrained users. A possible solution is textile-based surface EMG (sEMG) integrated into clothing and used as a wearable device. This is, however, challenging due to (i) uncertainties in the electrical properties of conductive threads used to construct electrodes, (ii) imprecise fabrication technologies (e.g., embroidery, sewing), and (iii) a lack of standardisation in the choice of design variables. This paper, for the first time, provides a design guide for such sensors by performing a thorough examination of the effect of design variables on sEMG quality. Electrical characterisation and sEMG measurements are performed, considering the effects of manufacturing imprecision. Results show that the imprecisions in digital embroidery lead to a trade-off between low electrode resistance and high consistency. An optimum set of variables for this trade-off is identified and tested with sEMG during a variable force isometric grip exercise with n=6 participants and compared with traditional gel-based electrodes. Results show that thread-based electrodes provide a similar level of sensitivity to force variation as gel-based electrodes with about 90% correlation with expected linear behaviour.
Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor.

AIMS The NADPH oxidase (NOX) family of enzymes catalyzes the formation of reactive oxygen species (ROS). NOX enzymes not only have a key role in a variety of physiological processes but also contribute to oxidative stress in certain disease states. To date, while numerous small molecule inhibitors have been reported (in particular for NOX2), none have demonstrated inhibitory activity in vivo. As such, there is a need for the identification of improved NOX inhibitors to enable further evaluation of the biological functions of NOX enzymes in vivo as well as the therapeutic potential of NOX inhibition. In this study, both the in vitro and in vivo pharmacological profiles of GSK2795039, a novel NOX2 inhibitor, were characterized in comparison with other published NOX inhibitors. RESULTS GSK2795039 inhibited both the formation of ROS and the utilization of the enzyme substrates, NADPH and oxygen, in a variety of semirecombinant cell-free and cell-based NOX2 assays. It inhibited NOX2 in an NADPH competitive manner and was selective over other NOX isoforms, xanthine oxidase, and endothelial nitric oxide synthase enzymes. Following systemic administration in mice, GSK2795039 abolished the production of ROS by activated NOX2 enzyme in a paw inflammation model. Furthermore, GSK2795039 showed activity in a murine model of acute pancreatitis, reducing the levels of serum amylase triggered by systemic injection of cerulein. INNOVATION AND CONCLUSIONS GSK2795039 is a novel NOX2 inhibitor that is the first small molecule to demonstrate inhibition of the NOX2 enzyme in vivo.
Cervical cancer screening among homeless women in the Greater Paris Area (France): results of the ENFAMS survey

Little is known about the prevalence of cervical cancer screening (CCS) and its correlates among homeless women in France. The objectives of this study were to determine the prevalence of women who had never been screened for cervical cancer and to identify the associated factors. This cross-sectional study was based on data collected in the ENFAMS survey, which was conducted in 2013 among 764 sheltered homeless mothers in the Greater Paris Area. Robust Poisson regression models were used to estimate the association between no lifetime CCS and certain sociodemographic and health-related factors (selected from the behavioral model of vulnerable populations). Analyses were carried out separately for women with and without a regular gynaecological follow-up (RGF). The proportion of never-screeners was 33% among the women with an RGF versus 64% among those without an RGF (P<0.001). Among the latter, never having been screened for CCS was associated mainly with socioeconomic conditions, the length of time lived in France, a history of delivery in France and the duration of homelessness. In those with an RGF, the factors were mainly poor health service utilization and language difficulties. This first quantitative study of CCS among homeless women in the Greater Paris Area points to the need for it to be proposed and performed more systematically in primary care. Every contact between this hard-to-reach population and health services should be an opportunity to check their screening status and to ensure that those in need actually undergo a Pap test.
Subjectivity Detection in Nuclear Energy Tweets

The subjectivity detection is an important binary classification task that aims at distinguishing natural language texts as opinionated (positive or negative) and non-opinionated (neutral). In this paper, we develop and apply recent subjectivity detection techniques to determine subjective and objective tweets towards the hot topic of nuclear energy. This will further help us to detect the presence or absence of social media bias towards Nuclear Energy. In particular, significant network motifs of words and concepts were learned in dynamic Gaussian Bayesian networks, while using Twitter as a source of information. We use reinforcement learning to update each weight based on a probabilistic reward function over all the weights and, hence, to regularize the sentence model. The proposed framework opens new avenues in helping government agencies manage online public opinion to decide and act according to the need of the hour.
The neuroanatomy of autism spectrum disorder: An overview of structural neuroimaging findings and their translatability to the clinical setting

Autism spectrum disorder is a complex neurodevelopmental disorder, which is accompanied by differences in brain anatomy, functioning and brain connectivity. Due to its neurodevelopmental character, and the large phenotypic heterogeneity among individuals on the autism spectrum, the neurobiology of autism spectrum disorder is inherently difficult to describe. Nevertheless, significant progress has been made in characterizing the neuroanatomical underpinnings of autism spectrum disorder across the human life span, and in identifying the molecular pathways that may be affected in autism spectrum disorder. Moreover, novel methodological frameworks for analyzing neuroimaging data are emerging that make it possible to characterize the neuroanatomy of autism spectrum disorder on the case level, and to stratify individuals based on their individual phenotypic make up. While these approaches are increasingly more often employed in the research setting, their applicability in the clinical setting remains a vision for the future. The aim of the current review is to (1) provide a general overview of recent structural neuroimaging findings examining the neuroanatomy of autism spectrum disorder across the human life span, and in males and females with the condition, (2) highlight potential neuroimaging (bio)markers that may in the future be used for the stratification of autism spectrum disorder individuals into biologically homogeneous subgroups and (3) inform treatment and intervention strategies.
Novel hybrid maximum power point tracking algorithm for PV systems under partially shaded conditions

Photovoltaic (PV) system has non-linear powervoltage (P-V) characteristic with single maximum power point (MPP) in uniform condition. The P-V curve would be more complicated during partially shaded (PS) conditions (PSCs) when multi-peak powers exist. The point with the highest value of power among the multi-peak powers is called global maximum power point (GMPP). In this paper, a novel hybrid method is proposed to obtain the GMPP in PSCs. In this method, if PS happens after reaching the MPP in uniform condition, the new operating point is specified based on modified linear function to reduce the searching zone and simultaneously the possible MPPs are recognized at the right side of the new obtained operating point. In the case where PS happens before reaching the MPP in uniform condition, the reference point is specified and then the location of GMPP is detected. Finally, after specifying the exact location of GMPP, the modified P&O is used to obtain the GMPP. To evaluate operation of the proposed method, simulation work has been carried out in MATLAB/Simulink where the GMPP is obtained in minimum time with high accuracy and minimum oscillation in power. Moreover, this method is not limited to any specific scenarios of shadowing.
Discordance in steatosis classification between liver biopsy and transient elastography for high controlled attenuation parameter (CAP) values

Abstract Objective The controlled attenuation parameter (CAP) measured by transient elastography allows for the noninvasive assessment of hepatic steatosis. However, discrepant results between CAP values and histological evaluation have been reported in particular with high CAP values. We therefore investigated the diagnostic validity of high CAP measurements. Methods Forty patients with liver disease and CAP measurements > 300 dB/m that underwent ultrasound-guided or minilaparoscopic liver biopsy were retrospectively enrolled. CAP values were compared with the respective histological and macroscopic evaluation and correlated with clinical parameters. Results CAP values > 300 dB/m had an 87.5 % specificity for detection of hepatic steatosis but failed to discriminate between steatosis grade S1 – S3. Discordant results, defined as a discrepancy of at least 2 steatosis grades between transient elastography and liver biopsy, were observed in 40 % of cases. The interquartile range (IQR) of CAP was confirmed as a predictor of discrepant findings. Macroscopic evaluation as part of minilaparoscopy detected hepatic steatosis in 74 % of patients with histological grade S2 – S3 in contrast to only 10 % classified as histological grade S0 – S1. Conclusion High CAP measurements need to be interpreted with care and with regard to clinical parameters, in particular when high IQR values are registered.
An Assessment Program for Accounting: Design, Implementation, and Reflection

This paper describes an assessment program for the undergraduate accounting degree program at a large, public university and highlights lessons learned in the application of this program. Faculty developed this program and have implemented assessment activities each year since 1993. Prior research has examined different aspects of designing and implementing accounting assessment programs. This paper adds to the literature by offering in‐depth, practical advice regarding implementation issues and by providing specific source information for several standardized tests and tools. This program and the lessons learned in implementing it should be of use to faculty who are in the early stages of assessment‐program development. This paper presents an overview of the assessment process, a full description of our assessment program, details of assessment methods, examples of the utilization of assessment results, and a recapitulation of lessons learned.
Molecular Docking in Formulation and Development.

BACKGROUND In pharmaceutical research drug discovery and development process is timeconsuming and expensive. In many cases, it produces incompetent results due to the failure of in vitro and in vivo conventional approaches. Before any new drug is placed in the market it must undergo rigorous testing to get FDA approval. Due to the several limitations imposed by the drug discovery process, in recent times in silico approaches are widely applied in this field. The purpose of this review is to highlight the current molecular docking strategies used in drug discovery and to explore various advances in the field. METHODS In this review we have compiled database after an extensive literature search on docking studies which has found its applications relevant to the field of formulation and development. The papers retrieved were further screened to appraise the quality of work. In depth strategic analysis was carried out to confirm the credibility of the findings. RESULTS The papers included in this review highlight the promising role of docking studies to overcome the challenges in formulation and development by emphasizing it's applications to predict drug excipient interactions which in turn assist to increase protein stability; to determine enzyme peptide interactions which maybe further used in drug development studies; to determine the most stable drug inclusion complex; to analyze structure at molecular level that ascertain an increase in solubility, dissolution and in turn the bioavailability of the drug; to design a dosage form that amplify the drug discovery and development process. CONCLUSION This review summarizes recent findings of critical role played by molecular docking in the process of drug discovery and development. The application of docking approach will assist to design a dosage form in the most cost effective and time saving manner.
The Antimicrobial Activity of a Carbon Monoxide Releasing Molecule (EBOR-CORM-1) Is Shaped by Intraspecific Variation within Pseudomonas aeruginosa Populations

Carbon monoxide releasing molecules (CORMs) have been suggested as a new synthetic class of antimicrobials to treat bacterial infections. Here we utilized a novel EBOR-CORM-1 ([NEt4][MnBr2(CO)4]) capable of water-triggered CO-release, and tested its efficacy against a collection of clinical Pseudomonas aeruginosa strains that differ in infection-related virulence traits. We found that while EBOR-CORM-1 was effective in clearing planktonic and biofilm cells of P. aeruginosa strain PAO1 in a concentration dependent manner, this effect was less clear and varied considerably between different P. aeruginosa cystic fibrosis (CF) lung isolates. While a reduction in cell growth was observed after 8 h of CORM application, either no effect or even a slight increase in cell densities and the amount of biofilm was observed after 24 h. This variation could be partly explained by differences in bacterial virulence traits: while CF isolates showed attenuated in vivo virulence and growth compared to strain PAO1, they formed much more biofilm, which could have potentially protected them from the CORM. Even though no clear therapeutic benefits against a subset of isolates was observed in an in vivo wax moth acute infection model, EBOR-CORM-1 was more efficient at reducing the growth of CF isolate co-culture populations harboring intraspecific variation, in comparison with efficacy against more uniform single isolate culture populations. Together these results suggest that CORMs could be effective at controlling genetically diverse P. aeruginosa populations typical for natural chronic CF infections and that the potential benefits of some antibiotics might not be observed if tested only against clonal bacterial populations.
Why do people donate to conservation? Insights from a ‘real world’ campaign

Non-governmental organisations (NGOs) play a key role in biodiversity conservation. The majority of these organisations rely on public donations to fund their activities, and therefore fundraising success is a determinant of conservation outcomes. In spite of this integral relationship, the key principals for fundraising success in conservation are still guided by expert opinion and anecdotal evidence, with very few quantitative studies in the literature. Here we assessed the behaviour of monetary donors across twenty-five different species-focused conservation campaigns organised by an NGO conservation and environmental society. The Australian Geographic Society (AGS) carried out fundraising campaigns over a five and half year period using an identical methodology in thirty-four of its country-wide network of outlet shops. AGS owns and operates these shops that sell toys and games related to science and nature. We tested how the following factors influenced monetary donations from members of the public:1) campaign duration, 2) appeal and familiarity of species, 3) species geographic distribution relative to the fundraising location, 4) level of income and education of potential donors, 5) age and gender profile of potential donors. Contrary to past research, we found most of these factors did not significantly influence the amount of donations made to each campaign by members of the public. Larger animals did elicit a significantly higher amount donated per transaction than smaller animals, as did shops located in poorer neighbourhoods. Our study findings contrast with past research that has focused largely on hypothetical donations data collected via surveys, and demonstrates the complexity and case-specific nature of relationships between donor characteristics and spending patterns. The study highlights the value of assessing real-world fundraising campaigns, and illustrates how collaboration between academia and NGOs could be used to better tailor fundraising campaigns to maximise donations from individual citizens.
Quantification of VOC emissions from paint spraying on a construction site using solid phase microextraction devices

ABSTRACT The objective of this study was to measure the emission of, and personal exposure to workers, volatile organic compound (VOC) during paint spraying on a construction site. Needle trap samplers (NTSs), which are a green solid phase microextraction sampling technology, were used to obtain air samples at a large music exhibition center. The standard active sampling method using charcoal tubes and a personal air pump, Method 1501, was simultaneously utilized at the sampling sites to assess the workers’ VOC exposures. Analysis of the data thus obtained showed that benzene, toluene, ethylenebenzene, and xylenes (BTEXs) were the main emission compounds. Acetone and isobutyl alcohol, which are used as thinning solvents, were detected as minor emission compounds. The emitted concentrations of most compounds were lower than the legal emission limits in Taiwan except that of benzene, for which the 2-ppm time weighted average short-term exposure limit was exceeded. The packed divinylbenzene (DVB) in the NTS was observed under an environmental scanning electron microscope, and many fine aerosols were found to be deposited on the surface of the DVB adsorbents, causing VOC extraction efficiencies after the fifth sampling in the field to decline. Workers on construction sites should be protected from emissions of VOC and fine particulates to preserve their occupational health.
Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment

The loss of dopaminergic neurons is a hallmark of Parkinson’s disease, the aetiology of which is associated with increased levels of oxidative stress. We used C. elegans to screen for genes that protect dopaminergic neurons against oxidative stress and isolated glit-1 (gliotactin (Drosophila neuroligin-like) homologue). Loss of the C. elegans neuroligin-like glit-1 causes increased dopaminergic neurodegeneration after treatment with 6-hydroxydopamine (6-OHDA), an oxidative-stress inducing drug that is specifically taken up into dopaminergic neurons. Furthermore, glit-1 mutants exhibit increased sensitivity to oxidative stress induced by H2O2 and paraquat. We provide evidence that GLIT-1 acts in the same genetic pathway as the previously identified tetraspanin TSP-17. After exposure to 6-OHDA and paraquat, glit-1 and tsp-17 mutants show almost identical, non-additive hypersensitivity phenotypes and exhibit highly increased induction of oxidative stress reporters. TSP-17 and GLIT-1 are both expressed in dopaminergic neurons. In addition, the neuroligin-like GLIT-1 is expressed in pharynx, intestine and several unidentified cells in the head. GLIT-1 is homologous, but not orthologous to neuroligins, transmembrane proteins required for the function of synapses. The Drosophila GLIT-1 homologue Gliotactin in contrast is required for epithelial junction formation. We report that GLIT-1 likely acts in multiple tissues to protect against 6-OHDA, and that the epithelial barrier of C. elegans glit-1 mutants does not appear to be compromised. We further describe that hyperactivation of the SKN-1 oxidative stress response pathway alleviates 6-OHDA-induced neurodegeneration. In addition, we find that mutations in the canonical apoptosis pathway and the calcium chaperone crt-1 cause increased 6-OHDA-induced dopaminergic neuron loss. In summary, we report that the neuroligin-like GLIT-1, the canonical apoptosis pathway and the calreticulin CRT-1 are required to prevent 6-OHDA-induced dopaminergic neurodegeneration.
User-based document ranking

The ranking of web documents is the key to present really significant results of a keyword-based search at first to users. Standard methods do not consider any user feedback so far and usually need a tremendous computation performance. The presented new approach considers access to web documents as the sole evaluation criterion and ensures that frequently accessed pages are recognised, can be found fast and are presented at the beginning of a search session. Furthermore, its locally working algorithms have been conceived to be applied in fully decentralised search systems in which no global knowledge base is available for this purpose.
A computational model of perceptuo-motor processing in speech perception: learning to imitate and categorize synthetic CV syllables

This paper presents COSMO, a Bayesian computational model, which is expressive enough to carry out syllable production, perception and imitation tasks using motor, auditory or perceptuo-motor information. An imitation algorithm enables to learn the articulatory-to-acoustic mapping and the link between syllables and correspond- ing articulatory gestures, from acoustic inputs only: syn- thetic CV syllables generated with a human vocal tract model. We compare purely auditory, purely motor and perceptuo-motor syllable categorization under various noise levels.
Differential perturbation of the interstitial cystitis-associated genes of bladder and urethra in rat model

ABSTRACT Interstitial cystitis (IC) is a chronic bladder dysfunction characterized as urinary frequency, urgency, nocturia, and pelvic pain. The changes in urethra may wind up with the bladder changes in structure and functions, however, the functions of the urethra in IC remains elusive. The aim of this study was to understand the perturbed gene expression in urethra, compared with urinary bladder, associated with the defected urodynamics. Using female IC mimic rats, a comprehensive RNA-sequencing combined with a bioinformatics analysis was performed and revealed that IC-specific genes in bladder or urethra. Gene ontology analysis suggested that the cell adhesion or extracellular matrix regulation, intracellular signaling cascade, cardiac muscle tissue development, and second messenger-mediated signaling might be the most enriched cellular processes in IC context. Further study of the effects of these bladder- or urethra-specific genes may suggest underlying mechanism of lower urinary tract function and novel therapeutic strategies against IC.