Miracle-dz/UniFAR-FTUs huggingface dataset:
Suppression of Transforming Growth Factor β Receptor 2 and Smad5 Is Associated with High Levels of MicroRNA miR-155 in the Oral Mucosa during Chronic Simian Immunodeficiency Virus Infection

ABSTRACT Chronic human immunodeficiency virus and simian immunodeficiency virus (HIV and SIV) infections are characterized by mucosal inflammation in the presence of anti-inflammatory cytokines such as transforming growth factor β (TGFβ). The mechanisms for refractiveness to TGFβ are not clear. Here we show that the expression of microRNA miR-155 was significantly upregulated in the oropharyngeal mucosa during chronic SIV infection and was coincident with downregulation of TGFβ receptor 2 (TGFβ-R2) and SMAD5, key TGFβ signaling genes that harbor putative target sites for miR-155. Ectopic expression of miR-155 in vitro was found to significantly downregulate TGFβ-R2 and Smad5 expression, suggesting a role for miR-155 in the suppression of TGFβ-R2 and SMAD5 genes in vivo. The downregulation of TGFβ signaling genes by miR-155 likely contributes to the nonresponsiveness to TGFβ during SIV infection and may inadvertently aid in increased immune activation during HIV and SIV infections.
An Authentication and Authorization Solution for a Multiplatform Cloud Environment

ABSTRACT Providing security at all levels within the multiplatform cloud-computing environment is has not been properly solved due to a variety of problems arising from technical and human-based sources. This paper presents an authentication-and-authorization solution based on the Single Sign-On (SSO) approach for cloud-service users and administrators in a multiplatform environment. The system developed enables user authentication for clouds provided as Infrastructure as a Service system built up from different OS systems. The solution enables the use of different services based on credentials that are authenticated only once and enable simple and efficient administration of the relevant data. The paper briefly presents the problem of user authentication in cloud services from the security aspect and defines the user and system administrator requirements for a secure and efficient authentication system. The implemented solution for two different platforms and the associated OS, one proprietary (WMware) and one open-source (OpenStack), is briefly described.
Design of WPT coils to minimize AC resistance and capacitor stress applied to SS-topology

The only loss in the lumped circuit model of a wireless power transfer system comes from the parasitic resistances, which usually becomes more problematic at higher frequencies. Resonant currents and voltages can also exert a large stress on the system. This paper presents a simple coil design procedure that minimizes the AC resistance and the stress of the compensating capacitors. It results in the lightest coil designs that can be chosen from commercially available Litz wires. Test setup using SS-topology achieved 98.6 % coil-to-coil efficiency with 18 cm air-gap and 0.6 kg coils.
Robbing Peter To Pay Paul: Breaking the RN "Recruitment Cycle"

As health care organizations struggle to fill their share of core vacant positions from a dwindling supply of registered nurses, there has been a focus on recruitment of nurses like never before. Investment in strategies to retain valuable and scarce nurse resources is necessary in order to create a sense of stability on the acute patient care unit (an attractive, but now seldom encountered, hospital environment characteristic). Once an atmosphere of work environment stability is established, nurses can be liberated and moved to focus on the meaning and value of the profession to the community, the nation, and the world.
Automatic Baseline Correction of Vibrational Circular Dichroism Spectra

A three-phase, computational method for the baseline correction of vibrational circular dichroism (VCD) spectra has been proposed. In the first phase the raw spectrum is subdivided into m segments (or regions) resulting in p rough estimates of the baseline. A second phase uses gradient characteristics to discriminate between baseline and band response for each baseline, in turn. In the final phase all baselines are interrogated simultaneously by assigning the median estimate of each differential response's distribution to the true baseline. Using VCD spectra of (R)-camphor as test cases, this work demonstrated that the accurate removal of baseline components is readily achievable with minimal user intervention. Baseline correction also demonstrated flexibility in that prior information, such as the symmetry of a baseline-free VCD spectrum, is readily used during the correction protocol. Although three adjustable parameters are present in the base algorithm, optimal performance and full automation were attainable following the use of analysis of variance (ANOVA) to analyze simulated bipolar spectra. These ANOVAs suggested that band point discrimination could be discarded and the remaining two default parameters adopted.
An ontology of Natural Disasters with exceptions

The Semantic Web is web of data and recognized as an effective infrastructure to elevate the visibility of knowledge on the Web. Ontology is the core of Semantic Web, which place a important role in conceptualizations Phase. Ontology development in the Semantic Web is supported by that various languages such as RDF, RDFS and OWL. We present a comparison of these languages. In this paper OWL is used to create the Knowledge Base in the domain of Natural Disasters including Exceptions by using Unless property. Unless property is defined in OWL as an Exclusive-OR operator.
Multiband planar inverted-F car antenna for mobile phone and GPS

With the rapid growth of new cellular communication systems on different frequency ranges and the introduction of satellite navigation systems (i.e. GPS) in modern cars a multitude of car antennas is required, which all have to be mounted on the car body. In the paper a multiband car antenna is presented, designed as a dual band planar inverted-F antenna (PIFA) with integrated additional GPS antenna.
Original Design of an Unmanned Ground Vehicle for Exploration in Rough Terrain

This paper introduces an originally designed tracked robot. This robot belongs to the variable geometry single-tracked vehicle (VGSTV) category. Two active joints are used to control the shape of the vehicle and the tension of the tracks. Thus, it becomes possible to adapt the shape of the robot and the ground/robot contact points to the obstacle by controlling the joints. This paper presents some unmanned ground vehicle architectures followed by an analysis of the prototype performance (in comparison with other VGSTVs). A description of its dynamic model is also presented in order to introduce the computation of two balance criteria: center of gravity and zero moment point. Finally, the relevance of these criteria is compared by discussing experimental results in the case of staircase clearing.
Foot and mouth disease seroprevalence in cattle in Kenya

A cross sectional study was conducted on serum from 39 counties in Kenya in order to determine the prevalence of foot and mouth disease in bovine species. The study utilized serum samples at Foot-andMouth Disease (FMD) laboratory including Somali Ecosystem Rinderpest Eradication Coordination Unit (SERECU) project collected in the year 2010. From the serology results, the national prevalence of foot and mouth disease in bovines was 52.5% (CI = 95). Of the 3709 samples subjected to Nonstructural protein (NSP) enzyme linked immunosorbent assay (ELISA) screening test, 1,947 of those were interpreted as positive representing 52.5% (1947/3709) while the other 1,762 samples turned negative representing 47.5% (n = 1,762). There was significant association between seropositivity and age groups (p = 0.002) and vaccination status (p = 0.048) but no association between the seropositivity and sex (p = 0.063).
Simple and rapid human papillomavirus genotyping method by restriction fragment length polymorphism analysis with two restriction enzymes

Cervical cancer, the third most common cancer that affects women worldwide, is caused by the human papillomavirus (HPV) and is treatable when detected at an early stage. To date, more than 100 different HPV types have been described, and the development of simple, low‐cost, and accurate methods to distinguish HPV genotypes is highly warranted. In this study, an HPV genotyping assay based on polymerase chain reaction (PCR) was evaluated. This method involved the use of MY09/11 primers followed by restriction fragment length polymorphism (RFLP) analysis with the restriction enzymes HpyCH4V and NlaIII. Cervical specimens preserved using CytoRich Blue fluid were collected from 1,134 female volunteers for HPV detection, and 1,111 valid samples were amplified using PCR. The PCR method was sensitive enough to detect 25 copies of HPV18, and three copies of HPV16. Out of 202 PCR‐positive samples, HPV genotypes were determined in 189 samples (93.6%) by this RFLP method. Results were then evaluated further by capillary sequencing method. Concordant results between the two tests were as high as 96.0%. Thirteen samples, which tested negative with RFLP, were verified as non‐specific amplifications with PCR. In conclusion, this PCR‐RFLP method using restriction enzymes HpyCH4V and NlaIII is simple, non‐labor intensive, and is applicable for the inexpensive determination of HPV genotypes in clinical samples. J. Med. Virol. 85:1229–1234, 2013. © 2013 Wiley Periodicals, Inc.
Real-time transposable element activity in individual live cells

Significance We have followed in real time how transposable elements, or “jumping genes,” move around in the genome of a living organism. Using a simple plasmid-borne transposable element, we have measured directly and precisely how frequently cells are affected by transposable elements and what factors contribute to their activity. We find the activity of this simple transposable element to be surprisingly rich, depending upon the host cell’s growth and environmental factors. Application of this system to more complex natural transposable elements will enable a quantitative understanding of these fundamental dynamical elements of all genomes, informing our understanding of genome plasticity and the mutations that can give rise to disease and drive evolution. The excision and reintegration of transposable elements (TEs) restructure their host genomes, generating cellular diversity involved in evolution, development, and the etiology of human diseases. Our current knowledge of TE behavior primarily results from bulk techniques that generate time and cell ensemble averages, but cannot capture cell-to-cell variation or local environmental and temporal variability. We have developed an experimental system based on the bacterial TE IS608 that uses fluorescent reporters to directly observe single TE excision events in individual cells in real time. We find that TE activity depends upon the TE’s orientation in the genome and the amount of transposase protein in the cell. We also find that TE activity is highly variable throughout the lifetime of the cell. Upon entering stationary phase, TE activity increases in cells hereditarily predisposed to TE activity. These direct observations demonstrate that real-time live-cell imaging of evolution at the molecular and individual event level is a powerful tool for the exploration of genome plasticity in stressed cells.
Determination of Hexanal as an Oxidative Marker in Vegetable Oils Using an Automated Dynamic Headspace Sampler Coupled to a Gas Chromatograph/Mass Spectrometer

An automated dynamic headspace sampler coupled to a gas chromatograph/mass spectrometer was evaluated as an oxidative marker to determine hexanal content in vegetable oils. For the effective analysis, a cooled injection system (CIS) was used to focus and to introduce the hexanal desorbed from the Tenax TA. The temperature of the CIS was maintained at −60°C for 12 min before desorbing the hexanal. Hexanal was separated on a capillary column (DB-5, 0.25 mm × 60 m, 0.25 µm in film thickness) from 50 to 230°C, followed by mass spectrometer-selected ion monitoring analysis at m/z 56. The instrumental response to hexanal was highly linear from 10 ng mL^−1 to 1 µg mL^−1 ( r ^2 = 0.9999). The relative standard deviation (RSD) of intra- and inter-day repeatability was acceptable, with values of less than 3.88 and 4.25%, respectively. The LOD and LOQ of hexanal were determined by gas chromatograph/mass spectrometer-selected ion monitoring to be 3.3 and 9.8 ng mL^−1, respectively. The acid value, peroxide value and fatty acid composition revealed a good correlation with the hexanal concentration.
$W$ -Band MMIC Amplifiers Based on AlInN/GaN HEMTs Grown on Silicon

We demonstrate W-band monolithic microwave integrated circuit (MMIC) amplifiers based on AlInN/GaN high electron mobility transistors (HEMTs) grown on Silicon. Our MMIC process was fully characterized to 110 GHz and a design kit generated to enable circuit design. A fabricated two-stage amplifier with an output device width of 100 μm shows a saturated output power of 18.3 dBm and a gain of 8.2 dB at 94 GHz with input/output return losses of -10 dB or better from 90 to 100 GHz. A model confirmed by experimental data revealed that the performance is limited by current collapse and that a doubling of output power could be possible by resolving collapse limitations, showing the considerable potential of GaN-on-Si HEMT technology for low-cost millimeter-wave power electronic applications.
Development of Mobile Robot SLAM Based on ROS

With the continuous development of intelligent robotics, intelligent robot can realize autonomous moving. Robot simultaneous localization and mapping technology arises at the historic moment. Adaptive monte carlo localization algorithm was used for mobile robot pose estimation. Bayesian algorithm was used to building grid map. The robot moving path was computed by the path planner algorithm. The mobile robot follows the path and realizes autonomous moving function. ROS platform was used for tracked mobile robot to realize the SLAM technology. Compared with conventional software development platform, ROS have strong focus on usability and ease of installation and have the advantages of free and open source. The experimental results demonstrated that ROS platform could greatly shorten the development cycle of the robot and the SLAM could easily realize on ROS, the robot can realize autonomous moving.
Software reliability modeling: accounting for program size variation due to integration or design changes

Estimation of software reliability quantities has traditionally been based on stable programs; i.e., programs that are completely integrated and are not undergoing design changes. Also, it is ordinarily assumed that all code is being executed at one time or another and that test or operational results are being completely inspected for failures. This paper describes a method for relaxing the foregoing conditions by adjusting the lengths of the intervals between failures experienced as compensation. The resulting set of failure intervals represents the set that would have occurred for a completely inspected program that was at all times in its final configuration. The failure intervals are then processed as they would be for a stable program. The approach is developed for the execution time theory of software reliability, but the concepts could be applied to many other models as well. Many definitions are given to describe program size variation and associated phenomena. Attention is focused on the special case of sequential integration and pure growth. The adjustment method is described and its benefits in improving the estimation of quantities of interest to the software manager are illustrated.
A MEMS VOA Using Electrothermal Actuators

A comprehensive study of electrothermally driven microelectromechanical system (MEMS) variable optical attenuator (VOA) devices using an H-shaped structure is presented in this paper. Based on its unique structural design, a retroreflection-type VOA of smaller footprint is realized. The repeatability and stability of the static and transient characteristics of attenuation behavior at various ambient temperatures are characterized. The fluctuation of attenuation curves under the same driving voltage at the same ambient temperatures is less than plusmn0.1 dB. Again, comparing the attenuation curves measured at 25 degC to 75 degC and at 25 degC to 12.5 degC, the deviation of attenuation under the same driving voltage is within the 0.6-dB range. Within the 40-dB attenuation range, the measured switching time from nonattenuation state to a particular attenuation state or between two attenuation states is less than 10 ms. This electrothermally actuated MEMS VOA also demonstrates the state-of-the-art dynamic attenuation stability that complies with the Telecordia GR1221 regulations, where the dynamic fluctuation of attenuation at 20 dB is less than plusmn0.36 dB under a vibration testing condition of 20 G periodical shocks with frequency from 20 Hz to 2 kHz
Analyse spatiale, évaluation et cartographie du risque glissement de terrain

RESUME : Pour evaluer et cartographier le risque « glissement de terrain », les techniques d'analyse spatiale et les technologies SIG sont rarement utilisees. En particulier, aucune etude concerne la cartographie automatique du risque « glissement de terrain » a grande echelle (1:10,000 e), echelle de travail correspondant a la cartographie reglementaire du risque naturel en France. Cet article presente une procedure en trois etapes pour evaluer et cartographier le risque « glissement de terrain » en associant plusieurs modeles d'analyse. Dans un premier temps, la susceptibilite (composante spatiale de l'alea) aux glissements de terrain est evaluee par un modele probabiliste bivarie (theorie de l'evidence). Le modele analyse les relations mathematiques entre des facteurs environnementaux de predisposition et l'occurrence spatiale des glissements de terrains passes et presents. Dans un deuxieme temps, leurs consequences potentielles (ou dommages) sont estimees par l'identification des elements a risques (enjeux) et de leurs valeurs dans un modele d'analyse semi-empirique. Enfin, le risque « glissement de terrain » est evalue en combinant les cartes de susceptibilite et les cartes de consequences. La methode a ete elaboree dans le cadre du projet europeen ALARM (Assessment of Landslide Risk and Mitigation in Mountain Areas, 2001-2004), et a ete testee dans le bassin ABSTRACT. Spatial analysis and GIS technology are still seldom used to evaluate and map landslide risk. Especially, few studies concern the automatic mapping of landslide risk at large scales (1:10,000) corresponding to the scale of the legal regulation plans in France. Maquaire et al., Analyse spatiale du risque « glissement de terrain » 2 This paper presents a three-step procedure to map landslide risk in mountain areas. First, landslide susceptibility (e.g. the spatial component of the hazard) is evaluated with a bivariate probabilistic model. The model simulates the relationship between several environmental factors controlling landslide location and the observed past and present landslide distribution. Second, landslide potential consequences (damage) are evaluated through the identification of the elements at risk (or stakes) and their value with a semi-empirical model. Finally, landslide risk is evaluated by combining the susceptibility maps and the consequence maps. The methodology has been developed within the EU-funded project ALARM (Assessment of Landslide Risk and Mitigation in Mountain Areas, 2001-2004) and has been applied in the Barcelonnette Basin (French South Alps). MOTS-CLES : glissement de terrain, risque, susceptibilite, analyse spatiale, modelisation, SIG
Three-dimensional modeling of a non-rigid object employing a single camera

This paper proposes a technique for recovering 3-D shape of a non-rigid object employing a single camera. Normally two or more cameras are necessary for recovering 3-D shape of a non-rigid object. Shape recovery of a non-rigid object employing a single camera has recently been studied by a few researchers, but they deal only with small deformation. The technique proposed in this paper achieves the shape recovery of larger deformation by regarding a non-rigid object as a set of rigid parts. Each rigid part recovers its 3-D shape by the application of the factorization method and they are connected mutually to represent an overall deformation of the object. The present technique also considers the shape recovery of an occluded part caused by ego motion. Effectiveness of the proposed technique is shown by experiment.
Rice tablet poisoning: A major concern in Iranian population

We have read with interest the recently published article by Shadania et al, entitled ‘A retrospective 7-year study of aluminum phosphide poisoning in Tehran: Opportunities for prevention’. As this is a common poisoning in Iran, we appreciate the opportunity to read about this poisoning. There are two kinds of rice tablets which are used in Iran to protect stored grains and rice from rodents and other household pests. Aluminum phosphide (ALP), a fumigant which releases toxic phosphine when it comes into contact with moisture, is the most common type of rice tablet. It is marketed as 3-gm tablets (Phostoxin Celphos, Quickphos and Phostek). Another tablet used for this purpose is a herbal product also known as Rice Tablet (Figure 1). Although public sale of ALP tablets is banned in Iran, it is still available. Both rice tablets are indistinguishable to the lay person and are used often for suicide purpose. The points which help in differentiating the two are change in appearance of the tablet when exposed to air (Figure 2) and its garlic-like odor. The herbal rice tablet is potentially harmless as it contains only botanical products unlike ALP, which releases phosphine. When a poisoned patient is brought to the emergency room it is difficult to differentiate the two. However, from looking at the container brought by patient’s relatives and clinical features, it is possible to differentiate the two. Further a silver nitrate breath test can be performed to detect phosphine. The mortality rate in ALP poisoning is high, resulting in 55-70% mortality in different studies. The blood pH was higher in this study (mean 7.3) unlike the study by Singh et al. where of 195 patients, 180 blood pH <7.3 with 62 having pH <6.9 in the study by Shadnia et al mortality was 31%. It is quite possible that in this study mortality was lower due to ingestion of exposed tablets which have lower phosphine content. As soon as ALP comes in contact with moisture, some phosphine gets released with resultant lower phosphine content in these exposed tablets and when someone ingests these tablets, lesser phosphine will be released in gut, resulting in less severe toxicity. A recent report from India suggests that a change in formulation from tablet to granulated powder has lead