Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute Hypoglycemia Decreases Myocardial Blood Flow Reserve in Patients With Type 1 Diabetes Mellitus and in Healthy Humans

Background— Hypoglycemia is associated with increased cardiovascular mortality, but the reason for this association is poorly understood. We tested the hypothesis that the myocardial blood flow reserve (MBFR) is decreased during hypoglycemia using myocardial contrast echocardiography in patients with type 1 diabetes mellitus (DM) and in healthy control subjects. Methods and Results— Twenty-eight volunteers with DM and 19 control subjects underwent hyperinsulinemic clamps with maintained sequential hyperinsulinemic euglycemia (plasma glucose, 90 mg/dL [5.0 mmol/L]) followed by hyperinsulinemic hypoglycemia (plasma glucose, 50 mg/dL [2.8 mmol/L]) for 60 minutes each. Low-power real-time myocardial contrast echocardiography was performed with flash impulse imaging using low-dose dipyridamole stress at baseline and during hyperinsulinemic euglycemia and hyperinsulinemic hypoglycemia. In control subjects, MBFR increased during hyperinsulinemic euglycemia by 0.57 U (22%) above baseline (B coefficient, 0.57; 95% confidence interval, 0.38 to 0.75; P<0.0001) and decreased during hyperinsulinemic hypoglycemia by 0.36 U (14%) below baseline values (B coefficient, −0.36; 95% confidence interval, −0.50 to −0.23; P<0.0001). Although MBFR was lower in patients with DM at baseline by 0.37 U (14%; B coefficient, −0.37; 95% confidence interval, −0.55 to −0.19; P=0.0002) compared with control subjects at baseline, the subsequent changes in MBFR during hyperinsulinemic euglycemia and hyperinsulinemic hypoglycemia in DM patients were similar to that observed in control subjects. Finally, the presence of microvascular complications in the patients with DM was associated with a reduction in MBFR of 0.52 U (24%; B coefficient, −0.52; 95% confidence interval, −0.70 to −0.34; P<0.0001). Conclusions— Hypoglycemia decreases MBFR in both healthy humans and patients with DM. This finding may explain the association between hypoglycemia and increased cardiovascular mortality in susceptible individuals.
Sustained but not repeated acute elevation of cortisol impaired the luteinizing hormone surge, estrus, and ovulation in gilts.

We tested the hypothesis that sustained and repeated acute elevation of cortisol would impair the LH surge, estrus, and ovulation in gilts. Cortisol was injected intramuscularly, to achieve a sustained elevation of plasma concentrations of cortisol, or intravenously, to achieve an acute elevation of plasma concentrations of cortisol. Control gilts received i.m. injections of oil and i.v. injections of saline. These treatments were administered to gilts (n = 6 per treatment) at 12-h intervals from Days 7 to 11 of the estrous cycle until after estrus ceased or until Day 27 or 28 of the estrous cycle, whichever came first. The repeated acute elevation of cortisol had no effect on the LH surge, estrus, or ovulation. In contrast, when the elevation of cortisol was sustained, the LH surge, estrus, and ovulation were inhibited. We conclude that cortisol is capable of direct actions to impair reproductive processes in female pigs but that plasma concentrations of cortisol need to be elevated for a substantial period for this to occur.
Recognising Informative Web Page Blocks Using Visual Segmentation for Efficient Information Extraction

As web sites are getting more complicated, the construction of web information ex- traction systems becomes more troublesome and time-consuming. A common theme is the diffi- culty in locating the segments of a page in which the target information is contained, which we call the informative blocks. This article reports on the Recognising Informative Page Blocks al- gorithm (RIPB), which is able to identify the informative block in a web page so that information extraction algorithms can work on it more efficiently. RIPB relies on an existing algorithm for vision-based page block segmentation to analyse and partition a web page into a set of visual blocks, and then groups related blocks with similar content structures into block clusters by using a tree edit distance method. RIPB recognises the informative block cluster by using tree align- ment and tree matching. A series of experiments were performed, and the conclusions were that RIPB was more than 95% accurate in recognising informative block clusters, and improved the efficiency of information extraction by 17%.
Dialysis Requiring Acute Kidney Injury in Acute Cerebrovascular Accident Hospitalizations

Background and Purpose— The epidemiology of dialysis requiring acute kidney injury (AKI-D) in acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH) admissions is poorly understood with previous studies being from a single center or year. Methods— We used the Nationwide Inpatient Sample to evaluate the yearly incidence trends of AKI-D in hospitalizations with AIS and ICH from 2002 to 2011. We also evaluated the trend of impact of AKI-D on in-hospital mortality and adverse discharge using adjusted odds ratios (aOR) after adjusting for demographics and comorbidity indices. Results— We extracted a total of 3 937 928 and 696 754 hospitalizations with AIS and ICH, respectively. AKI-D occurred in 1.5 and 3.5 per 1000 in AIS and ICH admissions, respectively. Incidence of admissions complicated by AKI-D doubled from 0.9/1000 to 1.7/1000 in AIS and from 2.1/1000 to 4.3/1000 in ICH admissions. In AIS admissions, AKI-D was associated with 30% higher odds of mortality (aOR, 1.30; 95% confidence interval, 1.12–1.48; P<0.001) and 18% higher odds of adverse discharge (aOR, 1.18; 95% confidence interval, 1.02–1.37; P<0.001). Similarly, in ICH admissions, AKI-D was associated with twice the odds of mortality (aOR, 1.95; 95% confidence interval, 1.61–2.36; P<0.01) and 74% higher odds of adverse discharge (aOR, 1.74; 95% confidence interval, 1.34–2.24; P<0.01). Attributable risk percent of mortality was high with AKI-D (98%–99%) and did not change significantly over the study period. Conclusions— Incidence of AKI-D complicating hospitalizations with cerebrovascular accident continues to grow and is associated with increased mortality and adverse discharge. This highlights the need for early diagnosis, better risk stratification, and preparedness for need for complex long-term care in this vulnerable population.
Experimental analysis of AODV, DSDV and OLSR routing protocol for flying adhoc networks (FANETs)

In recent years the capability and role of Mobile Adhoc Networks have rapidly evolved. Their use in emergency, natural disaster, military battle fields and UAVs is getting very popular as a result of cutting edge technologies in networking and communication. Using the concept of MANET new networking paradigms like VANET and FANET have evolved. FANET is comparably new concept of MANET and it has capabilities to tackle with situations where traditional MANET cannot do so. Due to high mobility and fast topology change in FANET, this is highly challengeable for researcher to implement routing in FANETs. Routing protocols play a dominating role in enhancing the performance of adhoc networks. In this paper, experimental analysis is carried out on AODV, DSDV and OLSR routing protocol for FANET environment using NS2 simulator.
RF ICs for commercial wireless applications

Prior to the advent of the commercial wireless communications market in the late 1980's, most RF circuit designs were destined for military applications. Since then, the size of the military market has declined, whilst the size of the wireless communications market has grown exponentially. With the move from low volume military applications to high volume commercial applications came ever increasing pressure for reduced cost, size and weight. This paper discusses the important trade-offs which must be made when designing RF ICs for use in high volume commercial wireless products and presents techniques which can be adopted to keep the costs down to the very low levels demanded by the market.
Traffic Accident Data Mining Using Machine Learning Paradigms

– Engineers and researchers in the automobile industry have tried to design and build safer automobiles, but traffic accidents are unavoidable. Patterns involved in dangerous crashes could be detected if we develop a prediction model that automatically classifies the type of injury severity of various traffic accidents. These behavioral and roadway patterns are useful in the development of traffic safety control policy. We believe that to obtain the greatest possible accident reduction effects with limited budgetary resources, it is important that measures be based on scientific and objective surveys of the causes of accidents and severity of injuries. This paper presents some models to predict the severity of injury that occurred during traffic accidents using three machine-learning approaches. We considered neural networks trained using hybrid learning approaches, decision trees and a concurrent hybrid model involving decision trees and neural networks. Experiment results reveal that among the machine learning paradigms considered the hybrid decision tree-neural network approach outperformed the individual approaches.
Reducing TLB power requirements

Translation look-aside buffers (TLBs) are small caches to speed-up address translation in processors with virtual memory. This paper considers two issues: (1) a comparison of the power consumption of fully-associative, set-associative, and direct mapped TLBs for the same miss rate and (2) the proposal of modifications of the basic cells and of the structure of set-associative TLBs to reduce the power. The power evaluation is done using a model and the miss rates are obtained from simulations of the SPEC92 benchmark. With respect to (1) we conclude that for small TLBs (high miss rates) fully-associative TLBs consume less power but for larger TLBs (low miss rates) set-associative TLBs are better. Moreover, the proposed modifications produce significant reductions in power consumption. Our evaluations show a reduction of 40 to 60% compared to the best traditional TLB. The proposed TLB implementation produces an increase in delay and in area. However, these increases are tolerable because the cycle time is determined by the slower cache and because the TLB area corresponds to only a small portion of the chip area.
Quantifying Memory Bandwidth Limitations of Current and Future Microprocessors

This paper makes the case that pin bandwidth will be a critical consideration for future microprocessors. We show that many of the techniques used to tolerate growing memory latencies do so at the expense of increased bandwidth requirements. Using a decomposition of execution time, we show that for modern processors that employ aggressive memory latency tolerance techniques, wasted cycles due to insufficient bandwidth generally exceed those due to raw memory latencies. Given the importance of maximizing memory bandwidth, we calculate effective pin bandwidth, then estimate optimal effective pin bandwidth. We measure these quantities by determining the amount by which both caches and minimal-traffic caches filter accesses to the lower levels of the memory hierarchy. We see that there is a gap that can exceed two orders of magnitude between the total memory traffic generated by caches and the minimal-traffic caches—implying that the potential exists to increase effective pin bandwidth substantially. We decompose this traffic gap into four factors, and show they contribute quite differently to traffic reduction for different benchmarks. We conclude that, in the short term, pin bandwidth limitations will make more complex on-chip caches cost-effective. For example, flexible caches may allow individual applications to choose from a range of caching policies. In the long term, we predict that off-chip accesses will be so expensive that all system memory will reside on one or more processor chips.
The diagnostic accuracy of Neuropad® for assessing large and small fibre diabetic neuropathy

Neuropad® is a simple visual indicator test, with moderate diagnostic performance for diabetic peripheral neuropathy. As it assesses sweating, which is a measure of cholinergic small nerve fibre function, we compared its diagnostic performance against established measures of both large and, more specifically, small fibre damage in patients with diabetes.
In situ evaluation of a low fluoride concentration gel with sodium trimetaphosphate in enamel remineralization.

PURPOSE To evaluate the capability of gels with low fluoride (F) concentration and supplemented with sodium trimetaphosphate (TMP) to promote in situ enamel remineralization. METHODS Bovine enamel blocks were selected on the basis of their surface hardness after demineralization, and divided into five groups: gel without F or TMP (placebo); gel with 4,500 ppm F (4,500); gel with 4,500 ppm F + 5% TMP (4,500 5% TMP); gel with 9,000 ppm F (9,000) and gel with 12,300 ppm F (12,300). The study design was blind and cross-over: 12 subjects used palatal devices with four demineralized enamel blocks for 3 days, after topical fluoride application (TFA). Two blocks were removed immediately for analysis of the loosely bound fluoride (CaF2) and firmly bound fluoride (F) after TFA in enamel. In the remaining blocks, the percentage of surface hardness recovery (% SH), cross-sectional hardness (deltaKHN) and CaF2 and F were determined after remineralization. The results were subjected to ANOVA and Bonferroni tests (P < 0.05). RESULTS The groups 4,500 5% TMP, 9,000, and 12,300 showed the best results with regard to % SH (P < 0.05). Lower deltaKHN values were observed in the 4,500 5% TMP and 12,300 gel groups (P < 0.05). Higher concentrations of CaF2 and F were observed in the 12,300 group, followed by the 4,500 5% TMP and 9,000 groups (P > 0.05). It was concluded that it is possible to promote enamel remineralization using gels with low fluoride concentration supplemented with TMP.
Mutual Authentication and Trust Bootstrapping towards Secure Disk Encryption

The weakest link in software-based full disk encryption is the authentication procedure. Since the master boot record must be present unencrypted in order to launch the decryption of remaining system parts, it can easily be manipulated and infiltrated by bootkits that perform keystroke logging; consequently, password-based authentication schemes become attackable. The current technological response, as enforced by BitLocker, verifies the integrity of the boot process by use of the trusted platform module. But, as we show, this countermeasure is insufficient in practice. We present STARK, the first tamperproof authentication scheme that mutually authenticates the computer and the user in order to resist keylogging during boot. To achieve this, STARK implements trust bootstrapping from a secure token to the whole PC. The secure token is an active USB drive that verifies the integrity of the PC and indicates the verification status by an LED to the user. This way, users can ensure the authenticity of the PC before entering their passwords.
A role for glutathione peroxidase in protecting pancreatic β cells against oxidative stress in a model of glucose toxicity

Antioxidant drugs have been reported to protect pancreatic islets from the adverse effects of chronic exposure to supraphysiological glucose concentrations. However, glucose has not been shown to increase intracellular oxidant load in islets, nor have the effects of increasing or inhibiting glutathione peroxidase (GPx) activity on islet resistance to sugar-induced oxidant stress been studied. We observed that high glucose concentrations increased intracellular peroxide levels in human islets and the pancreatic β cell line, HIT-T15. Inhibition of γ-glutamylcysteine synthetase (γGCS) by buthionine sulfoximine augmented the increase in islet peroxide and decrease in insulin mRNA levels, content, and secretion in islets and HIT-T15 cells induced by ribose. Adenoviral overexpression of GPx increased GPx activity and protected islets against adverse effects of ribose. These results demonstrate that glucose and ribose increase islet peroxide accumulation and that the adverse consequences of ribose-induced oxidative stress on insulin mRNA, content, and secretion can be augmented by a glutathione synthesis inhibitor and prevented by increasing islet GPx activity. These observations support the hypothesis that oxidative stress is one mechanism for glucose toxicity in pancreatic islets.
Toward Understanding the Catalytic Mechanism of Human Paraoxonase 1: Site-Specific Mutagenesis at Position 192

Human paraoxonase 1 (h-PON1) is a serum enzyme that can hydrolyze a variety of substrates. The enzyme exhibits anti-inflammatory, anti-oxidative, anti-atherogenic, anti-diabetic, anti-microbial and organophosphate-hydrolyzing activities. Thus, h-PON1 is a strong candidate for the development of therapeutic intervention against a variety conditions in human. However, the crystal structure of h-PON1 is not solved and the molecular details of how the enzyme hydrolyzes different substrates are not clear yet. Understanding the catalytic mechanism(s) of h-PON1 is important in developing the enzyme for therapeutic use. Literature suggests that R/Q polymorphism at position 192 in h-PON1 dramatically modulates the substrate specificity of the enzyme. In order to understand the role of the amino acid residue at position 192 of h-PON1 in its various hydrolytic activities, site-specific mutagenesis at position 192 was done in this study. The mutant enzymes were produced using Escherichia coli expression system and their hydrolytic activities were compared against a panel of substrates. Molecular dynamics simulation studies were employed on selected recombinant h-PON1 (rh-PON1) mutants to understand the effect of amino acid substitutions at position 192 on the structural features of the active site of the enzyme. Our results suggest that, depending on the type of substrate, presence of a particular amino acid residue at position 192 differentially alters the micro-environment of the active site of the enzyme resulting in the engagement of different subsets of amino acid residues in the binding and the processing of substrates. The result advances our understanding of the catalytic mechanism of h-PON1.
Prehypertension Is Not Associated with All-Cause Mortality: A Systematic Review and Meta-Analysis of Prospective Studies

Objectives Quantitative associations between prehypertension or its two separate blood pressure (BP) ranges and cardiovascular disease (CVD) or all-cause mortality have not been reliably documented. In this study, we performed a comprehensive systematic review and meta-analysis to assess these relationships from prospective cohort studies. Methods We conducted a comprehensive search of PubMed (1966-June 2012) and the Cochrane Library (1988-June 2012) without language restrictions. This was supplemented by review of the references in the included studies and relevant reviews identified in the search. Prospective studies were included if they reported multivariate-adjusted relative risks (RRs) and corresponding 95% confidence intervals (CIs) of CVD or all-cause mortality with respect to prehypertension or its two BP ranges (low range: 120–129/80–84 mmHg; high range: 130–139/85–89 mmHg) at baseline. Pooled RRs were estimated using a random-effects model or a fixed-effects model depending on the between-study heterogeneity. Results Thirteen studies met our inclusion criteria, with 870,678 participants. Prehypertension was not associated with an increased risk of all-cause mortality either in the whole prehypertension group (RR: 1.03; 95% CI: 0.91 to 1.15, P = 0.667) or in its two separate BP ranges (low-range: RR: 0.91; 95% CI: 0.81 to 1.02, P = 0.107; high range: RR: 1.00; 95% CI: 0.95 to 1.06, P = 0.951). Prehypertension was significantly associated with a greater risk of CVD mortality (RR: 1.32; 95% CI: 1.16 to 1.50, P<0.001). When analyzed separately by two BP ranges, only high range prehypertension was related to an increased risk of CVD mortality (low-range: RR: 1.10; 95% CI: 0.92 to 1.30, P = 0.287; high range: RR: 1.26; 95% CI: 1.13 to 1.41, P<0.001). Conclusions From the best available prospective data, prehypertension was not associated with all-cause mortality. More high quality cohort studies stratified by BP range are needed.
A Cocktail of Extracurricular Activities (ECAs): Different ECA Combinations and Their Association With Heavy Drinking in Two College Cohorts

The activities that students participate in are important to college life and outcomes. With regard to the problem outcome of heavy drinking, some activities pose risks (e.g., fraternity/sorority life) and others are protective (e.g., religious groups), yet students often participate in multiple activities. We estimated the odds of frequent heavy drinking as a function of all 2-, 3-, and 4-activity combinations (out of 10 total activities) in 2 separate college cohorts of 1,005 and 592 students. Findings showed that activities indeed combine to form informative high- and low-risk groups for intervention and advising, adding additional insight into the theory of college involvement.
Relation of growth of Streptococcus lactis and Streptococcus cremoris to amino acid transport

The maximum specific growth rate of Streptococcus lactis and Streptococcus cremoris on synthetic medium containing glutamate but no glutamine decreases rapidly above pH 7. Growth of these organisms is extended to pH values in excess of 8 in the presence of glutamine. These results can be explained by the kinetic properties of glutamate and glutamine transport (B. Poolman, E. J. Smid, and W. N. Konings, J. Bacteriol. 169:2755-2761, 1987). At alkaline pH the rate of growth in the absence of glutamine is limited by the capacity to accumulate glutamate due to the decreased availability of glutamic acid, the transported species of the glutamate-glutamine transport system. Kinetic analysis of leucine and valine transport shows that the maximal rate of uptake of these amino acids by the branched-chain amino acid transport system is 10 times higher in S. lactis cells grown on synthetic medium containing amino acids than in cells grown in complex broth. For cells grown on synthetic medium, the maximal rate of transport exceeds by about 5 times the requirements at maximum specific growth rates for leucine, isoleucine, and valine (on the basis of the amino acid composition of the cell). The maximal rate of phenylalanine uptake by the aromatic amino acid transport system is in small excess of the requirement for this amino acid at maximum specific growth rates. Analysis of the internal amino acid pools of chemostat-grown cells indicates that passive influx of (some) aromatic amino acids may contribute to the net uptake at high dilution rates.
A Practical Nonlinear Adaptive Control of Hydraulic Servomechanisms With Periodic-Like Disturbances

When performing periodic tasks, the modeling uncertainties will also present some periodicity. In this paper, by appropriately applying Fourier series approximation, a practical nonlinear adaptive repetitive controller is proposed for motion control of hydraulic servomechanisms to learn and compensate the periodic modeling uncertainties. Robust control term is also constructed to effectively attenuate the effect of approximation errors, and thus asymptotic tracking performance is achieved. In addition, robustness is also discussed with respect to other nonperiodic disturbances, which reveals a guaranteed transient performance and steady-state tracking accuracy can be achieved by the proposed controller with a practical assumption. Compared to the traditional repetitive controllers, the major advantage of this controller is that it not only requires little exact knowledge of the system dynamic structure or its parameters, but also greatly reduces the noise sensitivity and heavy memory requirements. Comparative experimental results are obtained to verify the high accuracy tracking performance of the proposed control strategy.