Miracle-dz/UniFAR-FTUs huggingface dataset:
A Convex Formulation for Semi-Supervised Multi-Label Feature Selection

Explosive growth of multimedia data has brought challenge of how to efficiently browse, retrieve and organize these data. Under this circumstance, different approaches have been proposed to facilitate multimedia analysis. Several semi-supervised feature selection algorithms have been proposed to exploit both labeled and unlabeled data. However, they are implemented based on graphs, such that they cannot handle large-scale datasets. How to conduct semi-supervised feature selection on large-scale datasets has become a challenging research problem. Moreover, existing multi-label feature selection algorithms rely on eigen-decomposition with heavy computational burden, which further prevent current feature selection algorithms from being applied for big data. In this paper, we propose a novel convex semi-supervised multi-label feature selection algorithm, which can be applied to large-scale datasets. We evaluate performance of the proposed algorithm over five benchmark datasets and compare the results with state-of-the-art supervised and semi-supervised feature selection algorithms as well as baseline using all features. The experimental results demonstrate that our proposed algorithm consistently achieve superiors performances.
Sulfenyl Halides as Modifying Reagents for Polypeptides and Proteins

The conversion of 2-thio-aryl-tryptophan and related derivatives to the corresponding 2-hydroxycompounds by acidic hydrolysis was investigated. The thioether function is introduced into the tryptophan residue by the selective reaction of sulfenyl halides with the indole nucleus. The substitution occurs under mild conditions only when the amino group of the tryptophan residue is free. The assistance of the amino group was confirmed using model compounds. Thus 2-thio-(2-nitrophenyl) -tryptamine is smoothly converted to 2-hydroxy-tryptamine whereas 2-thio- (2-nitrophenyl) -β-indolyl-propionic acid is completely stable under the same conditions. The conversion of 2-thio-aryl-tryptophan units linked in a polypeptide chain to the corresponding 2-hydroxy-tryptophan occurs only under conditions during which hydrolysis of the peptide bond occurs. It was also observed that the 2-nitro-thiophenols which are released during the hydrolysis of 2-thio- (2-nitrophenyl) -tryptophan and related compounds are converted under the conditions of the reaction to 2-aminobenzene sulfonic acids.
The Role of Storage Lipids in the Relation between Fecundity, Locomotor Activity, and Lifespan of Drosophila melanogaster Longevity-Selected and Control Lines

The contribution of insect fat body to multiple processes, such as development, metamorphosis, activity, and reproduction results in trade-offs between life history traits. In the present study, age-induced modulation of storage lipid composition in Drosophila melanogaster longevity-selected (L) and non-selected control (C) lines was studied and the correlation between total body fat mass and lifespan assessed. The trade-offs between fecundity, locomotor activity, and lifespan were re-evaluated from a lipid-related metabolic perspective. Fewer storage lipids in the L lines compared to the C lines supports the impact of body fat mass on extended lifespan. The higher rate of fecundity and locomotor activity in the L lines may increase the lipid metabolism and enhance the lipolysis of storage lipids, reducing fat reserves. The correlation between neutral lipid fatty acids and fecundity, as well as locomotor activity, varied across age groups and between the L and C lines. The fatty acids that correlated with egg production were different from the fatty acids that correlated with locomotor activity. The present study suggests that fecundity and locomotor activity may positively affect the lifespan of D. melanogaster through the inhibition of fat accumulation.
Positive Induction in the Acquisition and Extinction of Discrete-Trial Lever-Pressing in Rats

In two experiments, rats responding in a discrete-trial lever-pressing discrimination displayed positive induction during acquisition, i.e., shorter response latencies on S+ and Strials that immediately followed Strials. Positive induction was also observed during extinction: a group which received both Sand nonrewarded S+ trials during extinction displayed greater resistance to extinction to S+ than did a group receiving only S+ trials. This effect occurred only when subjects were required to respond on Strials during extinction. Response-noncontingent presentations of Sduring extinction failed to produce significant positive induction.
Detection of TMPRSS2:ERG fusion gene in circulating prostate cancer cells.

AIM To investigate the existence of TMPRSS2:ERG fusion gene in circulating tumor cells (CTC) from prostate cancer patients and its potential in monitoring tumor metastasis. METHODS We analyzed the frequency of TMPRSS2:ERG and TMPRSS2:ETV1 transcripts in 27 prostate cancer biopsies from prostatectomies, and TMPRSS2:ERG transcripts in CTC isolated from 15 patients with advanced androgen independent disease using reverse transcription polymerase chain reaction (RT-PCR). Fluorescence in situ hybridization (FISH) was applied to analyze the genomic truncation of ERG, which is the result of TMPRSS2:ERG fusion in 10 of the 15 CTC samples. RESULTS TMPRSS2:ERG transcripts were found in 44% of our samples, but we did not detect expression of TMPRSS2:ETV1. Using FISH analysis we detected chromosomal rearrangements affecting the ERG gene in 6 of 10 CTC samples, including 1 case with associated TMPRSS2:ERG fusion at the primary site. However, TMPRSS2:ERG transcripts were not detected in any of the 15 CTC samples, including the 10 cases analyzed by FISH. CONCLUSION Although further study is required to address the association between TMPRSS2:ERG fusion and prostate cancer metastasis, detection of genomic truncation of the ERG gene by FISH analysis could be useful for monitoring the appearance of CTC and the potential for prostate cancer metastasis.
Exposure to Family Violence as a Predictor of Dating Violence and Child-to-Parent Aggression in Spanish Adolescents

Witnessing intimate partner violence (IPV) and child maltreatment may place children on a lifelong trajectory toward violence. The primary aim of this research was to examine the associations between exposure to violence at home and two forms of violence in close relationships in Spanish adolescents: child-to-parent violence (CPV) and dating violence. A sample of 845 adolescents (13-18 years) completed measures of direct victimization and witnessing of IPV, as well as adolescent dating violence and CPV at Time 1, and measures of adolescent dating violence and CPV 6 months later. Findings indicate that direct victimization is more relevant for later CPV than is witnessing IPV against the mother. Namely, direct victimization by the mother and father predicted an increase in child-to-mother and child-to-father violence over time. Witnessing IPV and direct victimization by the father predicted an increase in dating violence victimization in girls at Time 2.
Rab10-mediated Endocytosis of the Hyaluronan Synthase HAS3 Regulates Hyaluronan Synthesis and Cell Adhesion to Collagen*

Background: Hyaluronan synthases (HASs) require transport to plasma membrane for the activation of hyaluronan (HA) synthesis. Results: Rab10 overexpression inhibited, whereas Rab10 silencing increased, cell surface HA coat and HAS3-dependent hyaluronan synthesis. Conclusion: Rab10 reduces the steady-state abundance of HAS3 in the plasma membrane by enhancing HAS3 endocytosis. Significance: HA synthesis is controlled by HAS3 endocytosis mediated by Rab10. Hyaluronan synthases (HAS1–3) are unique in that they are active only when located in the plasma membrane, where they extrude the growing hyaluronan (HA) directly into cell surface and extracellular space. Therefore, traffic of HAS to/from the plasma membrane is crucial for the synthesis of HA. In this study, we have identified Rab10 GTPase as the first protein known to be involved in the control of this traffic. Rab10 colocalized with HAS3 in intracellular vesicular structures and was co-immunoprecipitated with HAS3 from isolated endosomal vesicles. Rab10 silencing increased the plasma membrane residence of HAS3, resulting in a significant increase of HA secretion and an enlarged cell surface HA coat, whereas Rab10 overexpression suppressed HA synthesis. Rab10 silencing blocked the retrograde traffic of HAS3 from the plasma membrane to early endosomes. The cell surface HA coat impaired cell adhesion to type I collagen, as indicated by recovery of adhesion following hyaluronidase treatment. The data indicate a novel function for Rab10 in reducing cell surface HAS3, suppressing HA synthesis, and facilitating cell adhesion to type I collagen. These are processes important in tissue injury, inflammation, and malignant growth.
Nonlinear Model-Based Control of a Semi-Industrial Batch Crystallizer Using a Population Balance Modeling Framework

This paper presents an output feedback nonlinear model-based control approach for optimal operation of industrial batch crystallizers. A full population balance model is utilized as the cornerstone of the control approach. The modeling framework allows us to describe the dynamics of a wide range of industrial batch crystallizers. In addition, it facilitates the use of performance objectives expressed in terms of crystal size distribution. The core component of the control approach is an optimal control problem, which is solved by the direct multiple shooting strategy. To ensure the effectiveness of the optimal operating policies in the presence of model imperfections and process uncertainties, the model predictions are adapted on the basis of online measurements using a moving horizon state estimator. The nonlinear model-based control approach is applied to a semi-industrial crystallizer. The simulation results suggest that the feasibility of real-time control of the crystallizer is largely dependent on the discretization coarseness of the population balance model. The control performance can be greatly deteriorated due to inadequate discretization of the population balance equation. This results from structural model imperfection, which is effectively compensated for by using the online measurements to confer an integrating action to the dynamic optimizer. The real-time feasibility of the output feedback control approach is experimentally corroborated for fed-batch evaporative crystallization of ammonium sulphate. It is observed that the use of the control approach leads to a substantial increase, i.e., up to 15%, in the batch crystal content as the product quality is sustained.
Exposure to Low Doses of Endosulfan and Chlorpyrifos Modifies Endogenous Antioxidants in Tissues of Rats

Two experiments were conducted in male SD rats (225–250 g) to determine changes in the activities of endogenous antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and concentrations of glutathione (GSH) in tissues after exposure to low doses of endosulfan and chlorpyrifos using a whole body exposure technique. In both experiments, 6 rats/group were exposed 3 hr/day, 5 days/week for 30 days to: 0 (control), 5, 10, 20, 40 and 60% of LD50 of either pesticide in 50% ethanol; actual concentrations were: endosulfan = 0, 0.5, 1.0, 2.0, 4.0, 6.0 mg/250 g body weight; chlorpyrifos = 0, 1.9, 3.8, 7.6, 15.2, and 22.8 mg/250 g body weight. Endosulfan decreased erythrocyte SOD by 21% in all groups and chlorpyrifos increased SOD by 18% in groups 40 and 60. Liver SOD was 12%–20% lower after endosulfan exposure; lung SOD was altered: endosulfan decreased activity by 21% and 51% and chlorpyrifos by 58 and 75% in the 40 and 60 groups, respectively (P ≤ 0.05). Both pesticides increased plasma GPX activity at lower levels and reduced it by 26% and 19% in groups 40 and 60, respectively (P ≤ 0.05). Liver GPX increased in the 60 group and lung GPX declined between 20% and 38% after endosulfan exposure. GSH in the liver and lung: endosulfan reduced GSH by about 30% at lower levels and increased by 41% or 70% at higher levels; chlorpyrifos decreased GSH by 28–40% in 20 and 60 groups, respectively (P ≤ 0.05). Exposure to low, increasing levels of endosulfan and chlorpyrifos can differentially modify endogenous antioxidants SOD, GPX and GSH, which may lead to the development of oxidative stress in some tissues.
A knowledge management application to support knowledge sharing in a design engineering community

The changing competitive landscape has brought new forces to bear on the manner in which new products are developed. These forces have put the creation and dissemination of knowledge at the centre of many firms’ new product development (NPD) strategies. Organizational models to support NPD have evolved over the years and a significant aspect of this evolution has been the emergence of organizations that are decentralized and distributed across the globe. Improvements in communication infrastructure have facilitated this trend. These new organizational forms have placed stresses and strains on firm’s ability to efficiently transfer knowledge across its organization units and it has been observed that knowledge dissemination can run aground once organization unit boundaries are encountered. A small number of empirical analyses of knowledge management systems (KMS) applications to support new product development have been done. These analyses have pointed to a dual requirement in this area – firstly, an organizational environment that promotes knowledge dissemination and secondly, an IS infrastructure to support collaboration in and across new product development teams. While some of the extant literature on KMS to support knowledge dissemination stresses the importance of “people-topeople” KMS applications and the area of knowledge discovery is starting to get attention, there appears to be a dearth of published material on the issues surrounding the actual implementation of such systems in an industrial setting. In particular, the use of such systems in the context of NPD organizations does not appear to be well understood. This research hopes to address some of these shortcomings. This paper focuses on an application that has been developed by the Technical and Marketing IS (TMIS) group in ADI’s NPD organization. The purpose of the application is to facilitate the sharing of technical knowledge in the design engineering community in ADI.
The relationship between teacher stress and burnout in Hong Kong: positive humour and gender as moderators

ABSTRACT In this study, we report on the relationship between positive humour and burnout among 379 secondary school teachers in Hong Kong, and explore whether the relationship varies according to gender. The moderating effects of both affiliative and self-enhancing humour on each burnout component were then examined. High affiliative and self-enhancing humour were found to be associated with lower emotional exhaustion and depersonalisation but higher personal accomplishment. Further, the results indicated that low levels of affiliative and self-enhancing humour were related to more depersonalisation among females than among males. The results also partially supported the stress-moderating hypothesis, as affiliative humour was found to buffer the stress–depersonalisation relationship in this sample. These findings suggest that schools can design continuing education programmes based on the use of positive humour in helping teachers to cope with burnout.
Benchmarking the (1,4)-CMA-ES with mirrored sampling and sequential selection on the noiseless BBOB-2010 testbed

The well-known Covariance Matrix Adaptation Evolution Strategy (CMA-ES) is a robust stochastic search algorithm for optimizing functions defined on a continuous search space RD. Recently, mirrored samples and sequential selection have been introduced within CMA-ES to improve its local search performances. In this paper, we benchmark the (1,4ms)-CMA-ES which implements mirrored samples and sequential selection on the BBOB-2010 noiseless testbed. Independent restarts are conducted until a maximal number of 104 D function evaluations is reached. The experiments show that 11 of the 24 functions are solved in 20D (and 13 in 5D respectively). Compared to the function-wise target-wise best algorithm of the BBOB-2009 benchmarking, on 25% of the functions the (1,4ms)-CMA-ES is at most by a factor of 3.1 (and 3.8) slower in dimension 20 (and 5) for targets associated to budgets larger than 10D. Moreover, the (1,4ms)-CMA-ES slightly outperforms the best algorithm on the rotated ellipsoid function in 20D and would be ranked two on the Gallagher function with 101 peaks in 10D and 20D--being 25 times faster than the BIPOP-CMA-ES and about 3 times faster than the (1+1)-CMA-ES on this function.
Translation initiation of the replication initiator repB gene of 1 promiscuous plasmid pMV 158 is led by intrinsic non-SD 2 sequences 3

34 35 RepB is the pMV158-encoded protein that initiates rolling-circle 36 replication of this promiscuous plasmid. Availability of RepB is rate-limiting for 37 the plasmid replication process, and therefore the repB gene encoding the 38 protein is subjected to strict control. Two trans-acting plasmid elements, CopG 39 and the antisense RNAII, are involved in controlling the synthesis of the initiator 40 at the transcriptional and translational level, respectively. In addition to this dual 41 control of repB expression that senses and corrects fluctuations in plasmid copy 42 number, proper availability of RepB also relies on the adequate functionality of 43 the transcription and translation initiation regulatory signals. Translation of repB 44 has been postulated to depend on an atypical ribosome binding site that 45 precedes its start codon, although such a hypothesis has never been proved. 46 To define sequences involved in translation of repB, several mutations in the 47 translation initiation region of the repB mRNA have been characterized by using 48 an Escherichia coli in vitro expression system wherein the synthesis of RepB 49 was detected and quantified. We showed that translation of repB is not coupled 50 to that of copG and depends only on its own initiation signals. The atypical 51 ribosome binding site, as it was defined, is not involved in translation initiation. 52 However, the sequence just upstream of the repB start codon, encompassing 53 the proximal box of the atypical ribosome binding site and the four bases 54 immediately downstream of it, is indeed important for efficient translation of 55 repB. The high degree of conservation of this sequence among the rep genes of 56 plasmids of the same pMV158 family supports its relevancy as a translation 57 initiation signal in mRNAs without a recognizable Shine-Dalgarno sequence. 58
Abstraction of analytical models from cognitive models of human control of robotic swarms

© Proceedings of ICCM 2015 - 13th International Conference on Cognitive Modeling. In order to formally validate cyber-physical systems, analytically tractable models of human control are desirable. While those models can be abstracted directly from human data, limitations on the amount and reliability of data can lead to over-fitting and lack of generalization. We introduce a methodology for deriving formal models of human control of cyberphysical systems based on the use of cognitive models. Analytical models such as Markov models can be derived from an instance-based learning model of the task built using the ACT-R cognitive architecture. The approach is illustrated in the context of a robotic control task involving the choice of two options to control a robotic swarm. The cognitive model and various forms of the analytical model are validated against each other and against human performance data. The current limitations of the approach are discussed as well as its implications for the automated validation of cyber-physical systems.
Putative Prostate Cancer Risk SNP in an Androgen Receptor‐Binding Site of the Melanophilin Gene Illustrates Enrichment of Risk SNPs in Androgen Receptor Target Sites

Genome‐wide association studies have identified genomic loci, whose single‐nucleotide polymorphisms (SNPs) predispose to prostate cancer (PCa). However, the mechanisms of most of these variants are largely unknown. We integrated chromatin‐immunoprecipitation‐coupled sequencing and microarray expression profiling in TMPRSS2‐ERG gene rearrangement positive DUCaP cells with the GWAS PCa risk SNPs catalog to identify disease susceptibility SNPs localized within functional androgen receptor‐binding sites (ARBSs). Among the 48 GWAS index risk SNPs and 3,917 linked SNPs, 80 were found located in ARBSs. Of these, rs11891426:T>G in an intron of the melanophilin gene (MLPH) was within a novel putative auxiliary AR‐binding motif, which is enriched in the neighborhood of canonical androgen‐responsive elements. T→G exchange attenuated the transcriptional activity of the ARBS in an AR reporter gene assay. The expression of MLPH in primary prostate tumors was significantly lower in those with the G compared with the T allele and correlated significantly with AR protein. Higher melanophilin level in prostate tissue of patients with a favorable PCa risk profile points out a tumor‐suppressive effect. These results unravel a hidden link between AR and a functional putative PCa risk SNP, whose allele alteration affects androgen regulation of its host gene MLPH.
Transferred Flexible Three-Color Silicon Membrane Photodetector Arrays

We report the design and fabrication of transfer-printed flexible three-color multijunction 8 × 8 crystalline silicon membrane photodetector arrays. Based on the penetration-depth-dependent absorption of different wavelengths, filter-free color detection can be obtained via three junction photocurrent measurement. The optical measurements show good agreements with the optical behavior predicted by the design and simulation. No noticeable changes were observed in the device performance when it was operated in a bending state.
A Perceptuo-Motor Approach to Handwriting

The process of handwriting involves the complicated coordination of motor, perceptual and cognitive skills, which do not develop spontaneously but require considerable explanation, experimentation, demonstration and practice. This is an area in which pupil support services and occupational therapists are increasingly being asked for advice. This article describes the evaluation of a unique programme of motor and perceptual exercises, which aims to develop the control and presentation of the written word. The ‘Teodorescu’ programme has been found to be beneficial in improving the handwriting of many children, including those with mild learning difficulties and those with perceptuo-motor weaknesses.
The Impact of Childhood Psychological Abuse on Adult Interpersonal Conflict

Abstract The impact of childhood psychological abuse on adult interpersonal conflict was examined among 382 college women. Psychological abuse predicted adult interpersonal conflict above and beyond the effects of parenting behavior (i.e., parental warmth and control). The relationship between psychological abuse and conflict was mediated or partially mediated by three early maladaptive schemas: mistrust/abuse, abandonment, and defectiveness/shame. Paternal warmth had a significant, direct relationship with interpersonal conflict. The association between mistrust/ abuse schemas and interpersonal conflict was partially mediated by three patterns of interpersonal behavior: overly accommodating behavior, social isolation, and domineering/controlling behavior. Of the three patterns, domineering/controlling behavior explained the most variance in adult conflict. Findings provide support for the long-lasting impact of childhood psychological abuse and suggest that effects of psychological abuse persist via early maladaptive schemas.