Miracle-dz/UniFAR-FTUs huggingface dataset:
Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia

Aim TP53 mutation frequently occurs in solid cancers but not haematological cancers including acute promyelocytic leukaemia (APL) characterised by t(15;17). Both DAPK1 and p14ARF positively regulate p53 whereas miR-34a and -34b/c are direct transcriptional targets of p53. We studied if DNA methylation might contribute to inactivation of gene/microRNA (miRNA) in the TP53 tumour suppressor network. Methods Promoter methylation of DAPK1, p14ARF, miR-34a and -34b/c were studied in 10 normal bone marrow samples, NB4 cell line and 60 APL primary samples at diagnosis by methylation-specific PCR (MSP). Results DAPK1, p14ARF, miR-34a and -34b/c were completely unmethylated in normal bone marrow samples. DAPK1, miR-34a and -34b/c were completely methylated in NB4. Treatment of NB4 by 5′-Aza-2′-deoxyctidine resulted in promoter demethylation together with re-expression of DAPK1 and both miRNAs. In primary APL samples, methylation of miR-34b/c was detected in 43% in contrast to absence of methylation of DAPK1, p14ARF or miR-34a. Overexpression of miR-34b in NB4 resulted in inhibition of proliferation. Conclusions Methylation of DAPK1, miR-34a and -34b/c is tumour-specific, and associated with gene/miRNAs silencing. miR-34b/c is a tumour suppressor miRNA in APL. Methylation of miR-34b/c may contribute to APL leukaemogenesis.
Frequency coded chipless RFID tag localization using multiple antennas

In this paper a frequency coded chipless RFID localization algorithm is proposed. Unlike other techniques, one reader with multiple antennas is used to interrogate, identify and localize the tag. The Received Signal Strength (RSS) technique is used to detect the range of the tag, while Matrix Pencil Method (MPM) is used to calculate the Angle of Arrival (AoA). To validate both techniques a ray tracing tool was used to calculate the system link budget using tag RCS patterns exported from CST-MWS. The ray-tracing tool also calculated the interrogation zone considering all environmental factors. Moreover, a real-time testbed was created using fabricated chipless tags. The testbed was implemented using both measurement tools and Software Defined Radio (SDR). Both simulation and measurements show a great potential for the chipless tag to be used in localization and tracking application.
Complex-Network-Based Supply Chain Relationships Inference in Cloud Logistics Services

This paper tries to gain a more comprehensive understanding of the logistics discipline, supply chain optimization theory, and the complex networks. We formulate the inference problem to the cascade transmission model as the diffusion network inference problem. The inference model is also given out. In the experiment, our algorithm's performance is accepted. The precision is decreasing when the recall is increasing. The research can be used to reveal some mechanisms and the foundation of the logistics systems, supply chain system for the future cloud-based supply chain logistics service.
Deep Neural Network Based on Translation Model for Diabetes Knowledge Graph

Knowledge base completion (KBC) can predict new facts according to existed facts in knowledge base. However, most work in KBC is limited to simple neural networks and usually focuses on commonsense knowledge base where data resources are from public websites. Medical records related to diabetes from hospital showed potential advantages in both quality and quantity, which is significant to be mined for preventing or delaying diabetes and its complications. Thus, this paper designs and constructs Diabetes Knowledge Graph from electronic medical records in Shanghai Ruijing Hospital, and proposes a deep neural network based on translation model for completion in the diabetes knowledge graph. We manually evaluate our trained model's ability in accuracy, recall and F1-scores, finding that it has a good stability and performance in diabetes knowledge base completion.
Small‐Sample Estimation of Species Richness Applied to Forest Communities

Summary Many well‐known methods are available for estimating the number of species in a forest community. However, most existing methods result in considerable negative bias in applications, where field surveys typically represent only a small fraction of sampled communities. This article develops a new method based on sampling with replacement to estimate species richness via the generalized jackknife procedure. The proposed estimator yields small bias and reasonably accurate interval estimation even with small samples. The performance of the proposed estimator is compared with several typical estimators via simulation study using two complete census datasets from Panama and Malaysia.
Design of Highly Efficient Wideband RF Polar Transmitters Using the Envelope-Tracking Technique

This paper discusses the design issues of highly efficient and monolithic wideband RF polar transmitters, especially the ones that use the envelope-tracking (ET) technique. Besides first reviewing the current state-of-the-art polar transmitters in the literature, three focus topics will be discussed: 1) the system-on-a-chip (SoC) design considerations of the monolithic polar transmitter using ET versus EER (envelope elimination and restoration); 2) the design of highly efficient envelope amplifier capable of achieving the high efficiency, current, bandwidth, accuracy and noise specifications required for wideband signals; and 3) the design of high-efficiency monolithic Si-based class E power amplifiers (PAs) suitable for ET-based RF polar transmitters. A design prototype of a polar transmitter using ET and a monolithic SiGe PA that passed the stringent low-band EDGE (Enhanced Data rates for GSM Evolution) transmit mask with 45% overall transmitter system efficiency will be given; the simulated data of the entire polar transmitter system is also compared against the measurement. Further investigations on how to solve the technical challenges to successfully implement linear and high-efficiency ET-based polar transmitter for broadband wireless applications such as WiBro/WiMAX are also discussed.
Deconstructing shocks and persistence in OECD real exchange rates1)

Abstract We study the Purchasing Power Parity (PPP) hypothesis and the PPP puzzle for a sample of seventeen OECD economies when real exchange rates (RERs) are subject to multiple structural breaks. Applying recent panel econometric methods, we first show that RERs are found to be I(1) non-stationary processes when the analysis neglects structural breaks, while they are characterized as I(0) stationary stochastic processes when structural breaks are accommodated. This indicates that ignoring structural breaks can lead to model misspecification, which can bias (upward) shocks’ persistence measures. After controlling for structural breaks, our half-life point estimates appear below one year for both idiosyncratic and common measures of persistence of deviation from the changing mean.
Effects of Comparable Corpora on Cross-language Information Retrieval

This paper seeks to present an approach to learning bilingual terminology from scarce resources in order to translate and expand terms from source language to target language and possibly retrieve documents across languages. An extracted bilingual lexicon from comparable corpora will provide a valuable resource to enrich existing bilingual dictionaries and thesauri. A linear combination involving the extracted bilingual terminology from comparable corpora, readily available bilingual dictionaries and transliteration is proposed to Cross-Language Information Retrieval. An application on Japanese-English language pair of languages shows that the proposed combination yields better translations and an effectiveness of information retrieval could be achieved across languages.
In vivo 3D analysis with micro‐computed tomography of rat calvaria bone regeneration using periosteal cell sheets fabricated on temperature‐responsive culture dishes

Transplantable cell sheets containing osteoblasts were fabricated from periostea on temperature‐responsive culture dishes. This study demonstrated the time‐course of bone regeneration in living small animals. This continuous observation of bone regeneration was achieved by micro‐computed tomography (µCT), which assessed the osteogenic capability of periosteal cells without biodegradable scaffolds. Real‐time bone regeneration was non‐invasively monitored in a rat calvarial bone defect model, using µCT. Three‐dimensional (3D) images obtained over time by µCT clearly showed that two different bone regeneration modes, specific to the control and experimental groups, were observed. In the control group, bone was regenerated only from the periphery of the defect edges. In the experimental group, bone regeneration was observed in several small regions within the central portions of the defects that were covered by the transplanted cell sheets. However, bone regeneration observed after periosteal cell sheet transplantation was limited. The results of ALP staining and the time‐course observations concluded that periosteal cell sheets contained a small fraction of cells that could differentiate osteoblasts. Fibroblasts in transplanted cell sheets or from around subcutaneous tissues suppressed bone regeneration. The periosteal cell sheets had a capability to produce ectopic regenerated bones. Therefore, to increase the content of osteogenic cells in harvested cell sheets, the enrichment of cells that could produce osteoblasts was expected by the modification of the initial cell preparation and the culture conditions. With further possible improvements, scaffold‐free periosteal cell sheet fabricated on temperature‐responsive culture dishes will be a valuable method for inducing and accelerating bone regeneration. Copyright © 2010 John Wiley & Sons, Ltd.
Are ready-to-eat salads ready to eat? An outbreak of Salmonella Coeln linked to imported, mixed, pre-washed and bagged salad, Norway, November 2013

SUMMARY We investigated a nationwide outbreak of Salmonella Coeln in Norway, including 26 cases identified between 20 October 2013 and 4 January 2014. We performed a matched case-control study, environmental investigation and detailed traceback of food purchases to identify the source of the outbreak. In the case-control study, cases were found to be more likely than controls to have consumed a ready-to-eat salad mix (matched odds ratio 20, 95% confidence interval 2·7–∞). By traceback of purchases one brand of ready-to-eat salad was indicated, but all environmental samples were negative for Salmonella. This outbreak underlines that pre-washed and bagged salads carry a risk of infection despite thorough cleaning procedures by the importer. To further reduce the risk of infection by consumption of ready-to-eat salads product quality should be ensured by importers. Outbreaks linked to salads reinforce the importance of implementation of appropriate food safety management systems, including good practices in lettuce production.
Interleukin-12 secretion by Mycobacterium tuberculosis-infected macrophages

Infection with Mycobacterium tuberculosis or phagocytosis of large latex beads induced interleukin-12 (IL-12) production in macrophages. In contrast, tumor necrosis factor (TNF) was produced only in response to M. tuberculosis infection, not after phagocytosis of latex beads. Comparable results were obtained with cells from immunocompetent C57BL/6 and gamma interferon receptor-deficient mutant mice. Thus, phagocytosis by mechanisms not specific for M. tuberculosis was a sufficient trigger for IL-12 secretion, emphasizing the central role of this cytokine in the initiation of anti-infective immunity.
Gender-Specific Association Between the Metabolic Syndrome and Arterial Stiffness in 8,300 Subjects

Background:The objective of this study was to determine the sex-specific association between the metabolic syndrome (MetS) and arterial stiffness. Methods:In this cross-sectional study, 3981 women and 4319 men aged 20 to 79 years were analyzed. All participants underwent the measurement of waist circumference, blood pressure (BP), brachial-ankle pulse wave velocity (baPWV) and blood chemistry. baPWV levels were compared between men and women using the Mann-Whitney's U test. Subjects with or without MetS and its components or specific clusters of MetS components in the different sexes were compared by the Kruskal-Wallis test. Binary logistic regression analysis was performed to evaluate the relationship between baPWV and the MetS components. Results:Women had lower baPWV than men in young and middle-aged subjects (P < 0.001), but there was no difference in the elderly subjects. baPWV levels in women were higher than in men with MetS and its components except for high-density lipoprotein cholesterol (HDL-C; P < 0.01). The combination of elevated triglycerides, elevated BP and elevated fasting glucose (with obesity or low HDL-C) had a greater baPWV than the other clusters. All the metabolic variables were positively correlated with baPWV except for HDL-C negatively correlating in women (P < 0.001), whereas age, BP and fasting glucose were moderately associated with baPWV in men (P < 0.001). Among the MetS components, BP had the strongest association with baPWV. Conclusions:The MetS and its components affect arterial stiffness more severely in women than in men. More importance to women with MetS should be given.
Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro

Purpose: The aim of the study was to examine the effects of resveratrol upon hepatic endoplasmic reticulum stress (ERS) and insulin sensitivity in vivo and in vitro. Material and methods: C57BL/6J mice were fed a high-fat diet (HFD) for 8 weeks, and insulin resistance was evaluated by the intraperitoneal glucose tolerance test (IPGTT). Mice were then treated with resveratrol for 12 weeks and blood and liver samples collected. Blood biochemical indicators were determined by kits, liver protein expression was determined by western blot, and morphological changes were observed by histological staining. Palmitic acid (PA)-induced insulin-resistant HepG2 cells were established. Cells were exposed to 100, 50 or 20 μM resveratrol for 24 hrs, and proliferation/cytotoxicity was determined. Cells were divided into five groups: control, PA, PA + Rev (100 μM), PA + Rev (50 μM) and PA + Rev (20 μM) groups. After 24 hrs of treatment, cellular proteins were analyzed the same way as animal tissues. Results: The IPGTT confirmed that the insulin resistance model was established successfully. After resveratrol treatment, fasting blood glucose and cholesterol levels declined and the quantitative insulin sensitivity check index increased. Western-blot results showed that resveratrol-treated HFD mice had reduced hepatic levels of p-PERK, ATF-4 and TRIB3, and increased the levels of ATF-6, p-AKT and p-GSK3β. In the cell model, resveratrol with 100 and 50 μM enhanced ERS and insulin resistance, whereas 20 μM had beneficial effects, similar to the animal model. Conclusion: Resveratrol reduced hepatic ERS, thereby improving insulin sensitivity and glucose levels. However, high doses of resveratrol had harmful effects on cells, elevating ERS and insulin resistance. The safe dose of resveratrol needs further investigation.
Endogenous Legal Change: How Organizations Re-Shaped Glass-Steagall

This article develops a strategic and interest-based framework to describe how organizations shape the content, meaning, and effects of the laws that govern their actions. Prior work has demonstrated the endogenous nature of legal change by examining how organizational responses to ambiguous legislative mandates can become institutionalized and accepted by courts as legitimate indicators of compliance. Although these studies have generated insights about how organizations influence the law, the institutional pathways examined in this literature represent only one of many sources of legal endogeneity. This article offers a substantial reconceptualization of legal endogeneity that includes a broader set of both strategic and institutional processes. The authors identify three strategies by which organizations actively seek to alter stable legal environments and produce endogenous change. First, organizations take advantage of the flexibility inherent in any system of rules to reinterpret the law. Second, organizations engage in new activities not covered by existing rules, and thus innovate around the law. Third, organizations engage legislatures to change existing laws or propose new ones. We identify and explore these strategies through an analysis of the slow demise of the separation of commercial and investment banking established in the Glass-Steagall Act of 1933.
Molecular mechanisms of low dose ionizing radiation-induced hormesis, adaptive responses, radioresistance, bystander effects, and genomic instability

Abstract Purposes: To review research progress on the molecular mechanisms of low dose ionizing radiation (LDIR)-induced hormesis, adaptive responses, radioresistance, bystander effects, and genomic instability in order to provide clues for therapeutic approaches to enhance biopositive effects (defined as radiation-induced beneficial effects to the organism), and control bionegative effects (defined as radiation-induced harmful effects to the organism) and related human diseases. Conclusions: Experimental studies have indicated that Ataxia telangiectasia-mutated (ATM), extracellular signal-related kinase (ERK), mitogen-activated protein kinase (MAPK), phospho-c-Jun NH2-terminal kinase (JNK) and protein 53 (P53)-related signal transduction pathways may be involved in LDIR-induced hormesis; MAPK, P53 may be important for adaptive response; ATM, cyclooxygenase-2 (COX-2), ERK, JNK, reactive oxygen species (ROS), P53 for radioresistance; COX-2, ERK, MAPK, ROS, tumor necrosis factor receptor alpha (TNFα) for LDIR-induced bystander effect; whereas ATM, ERK, MAPK, P53, ROS, TNFα-related signal transduction pathways are involved in LDIR-induced genomic instability. These results suggest that different manifestations of LDIR-induced cellular responses may have different signal transduction pathways. On the other hand, LDIR-induced different responses may also share the same signal transduction pathways. For instance, P53 has been involved in LDIR-induced hormesis, adaptive response, radioresistance and genomic instability. Current data therefore suggest that caution should be taken when designing therapeutic approaches using LDIR to induce beneficial effects in humans.
A review of literature on training transfer motivation and psychological capital

As training and development, along with continuous learning has become an important aspect of work, the effectiveness of the transfer of knowledge, skills and behaviours to the workplace have been called into question. A meta-analysis of training transfer has called to move beyond contextual constraints to evaluate the psychological traits and states that impact training transfer motivation. The recent field of positive organisational behaviour, specifically the positive higher order state, Psychological Capital, is reviewed in relation to its potential to meet calls to evaluate psychological traits and states in relation to training transfer motivation. Research questions are posed for future research incorporating pre-training motivation and trainee’s positive psychological states, through Psychological Capital.
Under Consideration for Publication in J. Functional Programming F U N C T I O N a L P E a R L Linear, Bounded, Functional Pretty-printing

We present two implementations of Oppen's pretty-printing algorithm in Haskell that meet the efficiency of Oppen's imperative solution but have a simpler, clear structure. We start with an implementation that uses lazy evaluation to simulate two cooperating processes. Then we present an implementation that uses higher-order functions for delimited continuations to simulate co-routines with explicit scheduling.
Crocodylian Head Width Allometry and Phylogenetic Prediction of Body Size in Extinct Crocodyliforms

Synopsis Body size and body-size shifts broadly impact life-history parameters of all animals, which has made accurate body-size estimates for extinct taxa an important component of understanding their paleobiology. Among extinct crocodylians and their precursors (e.g., suchians), several methods have been developed to predict body size from suites of hard-tissue proxies. Nevertheless, many have limited applications due to the disparity of some major suchian groups and biases in the fossil record. Here, we test the utility of head width (HW) as a broadly applicable body-size estimator in living and fossil suchians. We use a dataset of sexually mature male and female individuals (n = 76) from a comprehensive sample of extant suchian species encompassing nearly all known taxa (n = 22) to develop a Bayesian phylogenetic model for predicting three conventional metrics for size: body mass, snout–vent length, and total length. We then use the model to estimate size parameters for a select series of extinct suchians with known phylogenetic affinity (Montsechosuchus, Diplocynodon, and Sarcosuchus). We then compare our results to sizes reported in the literature to exemplify the utility of our approach for a broad array of fossil suchians. Our results show that HW is highly correlated with all other metrics (all R2≥0.85) and is commensurate with femoral dimensions for its reliably as a body-size predictor. We provide the R code in order to enable other researchers to employ the model in their own research.
Comparing Slicing Technologies for Digital Light Processing Printing

In additive manufacturing (AM), slicing is a crucial step in process planning to convert a computer-aided design (CAD) model to a machine-specific format. Digital light processing (DLP) printing is an important AM process that has a good surface finish, high accuracy, and fabrication speed and is widely applied in many dental and engineering industries. However, as DLP uses images for fabrication different from other toolpath-based processes, its process planning is understudied. Therefore, the main goal of this paper is to study and compare the slicing technologies for DLP printing. Three slicing technologies are compared: contour, voxelization, and ray-tracing.
A Method to Start Rotating Induction Motor Based on Speed Sensorless Model-Predictive Control

In some cases, such as restarting after power interruption or starting a motor rotated by external load, the motor may be rotating before being powered by the inverter. For speed-sensorless operation, as both the initial rotational direction and speed is unknown, it would be difficult to achieve smooth and fast resumption of normal operation if the starting scheme is not deliberately designed. In this paper, a method based on adaptive full order observer (AFO) is proposed to address this problem. For AFO without a properly designed feedback gain matrix, the estimated speed cannot converge to the actual speed if initial estimated speed is significantly lower than the actual speed. Through analyzing the transfer function of stator current error, the convergence condition of speed estimation is deduced. A feedback gain matrix and the condition for shifting to normal operation are subsequently proposed to improve restarting performance. The detailed design and implementation of the proposed method combined with finite control set model-predictive flux control is illustrated. Simulation and experimental results validate the effectiveness of the developed schemes.