Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunopathology and Infectious Diseases The LTB 4-BLT 1 Axis Mediates Neutrophil Infiltration and Secondary Injury in Experimental Spinal Cord Injury

Traumatic injury in the central nervous system induces inflammation; however, the role of this inflammation is controversial. Precise analysis of the inflammatory cells is important to gain a better understanding of the inflammatory machinery in response to neural injury. Here, we demonstrated that leukotriene B4 plays a significant role in mediating leukocyte infiltration after spinal cord injury. Using flow cytometry, we revealed that neutrophil and monocyte/macrophage infiltration peaked 12 hours after injury and was significantly suppressed in leukotriene B4 receptor 1 knockout mice. Similar findings were observed in mice treated with a leukotriene B4 receptor antagonist. Further, by isolating each inflammatory cell subset with a cell sorter, and performing quantitative reverse transcription-PCR, we demonstrated the individual contributions of more highly expressed subsets, ie, interleukins 6 and 1 , tumor necrosis factor, and FasL, to the inflammatory reaction and neural apoptosis. Inhibition of leukotriene B4 suppressed leukocyte infiltration after injury, thereby attenuating the inflammatory reaction, sparing the white matter, and reducing neural apoptosis, as well as inducing better functional recovery. These findings are the first to demonstrate that leukotriene B4 is involved in the pathogenesis of spinal cord injury through the amplification of leukocyte infiltration, and provide a potential therapeutic strategy for traumatic spinal cord injury. (Am J Pathol 2010, 176:2352–2366; DOI: 10.2353/ajpath.2010.090839)
Oxidative Pathway for the Biodegradation of Nitrobenzene by Comamonas sp. Strain JS765

Previous studies have shown that the biodegradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45 proceeds by the reduction of nitrobenzene through nitrosobenzene and hydroxylaminobenzene, followed by rearrangement to 2-aminophenol, which then undergoes meta ring cleavage. We report here the isolation of a Comamonas sp. that uses an oxidative pathway for the complete mineralization of nitrobenzene. The isolate, designated strain JS765, uses nitrobenzene as a sole source of carbon, nitrogen, and energy. Nitrobenzene-grown cells oxidized nitrobenzene, with the stoichiometric release of nitrite. Extracts of nitrobenzene-grown JS765 showed high levels of catechol 2,3-dioxygenase activity that were not abolished by heating the cell extracts to 60(deg)C for 10 min. The ring cleavage product had an absorbance maximum at 375 nm, consistent with that of 2-hydroxymuconic semialdehyde. Both NAD-dependent dehydrogenase and NAD-independent hydrolase activities towards 2-hydroxymuconic semialdehyde were induced in extracts of nitrobenzene-grown cells. Catechol accumulated in the reaction mixture when cells preincubated with 3-chlorocatechol were incubated with nitrobenzene. Conversion of nitrobenzene to catechol by induced cells in the presence of 3-chlorocatechol and (sup18)O(inf2) demonstrated the simultaneous incorporation of two atoms of oxygen, which indicated that the initial reaction was dioxygenation. The results indicate that the catabolic pathway involves an initial dioxygenase attack on nitrobenzene with the release of nitrite and formation of catechol, which is subsequently degraded by a meta cleavage pathway.
Text Independent Speaker Identification with Finite Multivariate Generalized Gaussian Mixture Model with Distant Microphone Speech

An effective and efficient speaker Identification (SI) system requires a robust feature extraction module followed by a speaker modeling scheme for generalized representation of these features. In recent, years Speaker Identification has seen significant advancement, but improvements have tended to be bench marked on the near field speech, ignoring the more realistic setting of far field instrumented speaker. A novel speaker model is developed by using Finite Multivariate Generalized Gaussian Mixture Model, Minimum Variance Distortion less Response Cepstral coefficients as feature Vectors. The performance of the developed model is studied through experimental evaluation with 45 speaker‟s data base and identification accuracy.
The COX-2 Selective Blocker Etodolac Inhibits TNFα-Induced Apoptosis in Isolated Rabbit Articular Chondrocytes

Chondrocyte apoptosis contributes to the disruption of cartilage integrity in osteoarthritis (OA). Recently, we reported that activation of volume-sensitive Cl− current (ICl,vol) mediates cell shrinkage, triggering apoptosis in rabbit articular chondrocytes. A cyclooxygenase (COX) blocker is frequently used for the treatment of OA. In the present study, we examined in vitro effects of selective blockers of COX on the TNFα-induced activation of ICl,vol in rabbit chondrocytes using the patch-clamp technique. Exposure of isolated chondrocytes to TNFα resulted in an obvious increase in membrane Cl− conductance. The TNFα-evoked Cl− current exhibited electrophysiological and pharmacological properties similar to those of ICl,vol. Pretreatment of cells with selective COX-2 blocker etodolac markedly inhibited ICl,vol activation by TNFα as well as subsequent apoptotic events such as apoptotic cell volume decrease (AVD) and elevation of caspase-3/7 activity. In contrast, a COX-1 blocker had no effect on the decrease in cell volume or the increase in caspase-3/7 activity induced by TNFα. Thus, the COX-2-selective blocker had an inhibitory effect on TNFα-induced apoptotic events, which suggests that this drug would have efficacy for the treatment of OA.
The Relationship Among Personality, Cognitive Anxiety, Somatic Anxiety, Physiological Arousal, and Performance in Male Athletes

The present study examined the association between personality, competitive anxiety, somatic anxiety and physiological arousal in athletes with high and low anxiety levels. Anxiety was manipulated by means of an incentive. Fifty male participants, first, completed the Five Factor Personality Inventory and their resting electro dermal activity (EDA) was recorded. In the second stage, participants were randomly assigned to high or low anxiety groups. Individual EDAs were recorded again to determine precompetition physiological arousal. Participants also completed the Competitive State Anxiety Inventory-2 (CSAI-2) and played a computer-simulated soccer match. Results showed that neuroticism was related to both CSAI-2 components and physiological arousal only in the group receiving the incentive. Winners had higher levels of cognitive anxiety and lower levels of physiological arousal than losers. On the basis of these findings, we concluded that an athlete’s neurotic personality may influence his cognitive an.
Annotating a corpus of clinical text records for learning to recognize symptoms automatically

We report on a research effort to create a corpus of clinical free text records enriched with annotation for symptoms of a particular disease (ovarian cancer). We describe the original data, the annotation procedure and the resulting corpus. The data (approximately 192K words) was annotated by three clinicians and a procedure was devised to resolve disagreements. We are using the corpus to investigate the amount of symptom-related information in clinical records that is not coded, and to develop techniques for recognizing these symptoms automatically in unseen text.
Looks familiar, appears more valid? The moderating role of computer-supported warnings between information repetition and decision outcome

The purpose of this study is to understand whether warning messages help decision-makers recognise redundancy bias and reduce the effects of such bias during exposure to redundant information. We proposed a mechanism to reduce the effect of redundancy bias by presenting computer-supported warning messages during the decision process as a debiasing method, and tested this method via a longitudinal experiment with 108 subjects. Warnings could serve as an effective reminder of the presence of redundancy bias and reduce irrational increases in confidence. Further, these warnings could encourage people to carefully consider and adjust their decisions. The results showed that redundancy leads to repeated statements being rated as more valid than non-repeated statements. As predicted, with the help of the warnings, the participants were able to carefully reconsider and adjust their decisions, and they were somewhat satisfied with this feature.
Adaptive local tone mapping of color images

In this paper we propose an adaptive method for local tone mapping in which the vicinity of the current pixel is adaptively selected in order to reduce the artifacts near edges. In addition to that, the only parameter controlling the global effect of the tone mapping is adaptively computed based on the statistics of the processed image. To introduce our method, we start from a simple analysis of the tone mapping model and we validate our method by experimental results. Finally, we compare our method with an existing local tone mapping approach.
Psychosocial Treatments for Children with Autism Spectrum Disorder

Given the situation where various psychosocial treatments for autism spectrum disorder (ASD) are proposed and body of treatment outcome studies for ASD are accumulated, this study purported to review psychosocial treatments for children with ASD that currently receive empirical supports. To address these purposes, the study focused on the three types of psychosocial treatments frequently observed in ASD literature (behavioral interventions, social-communication skills interventions, and parent training interventions), and reviewed research findings pertaining to each of these interventions. Toward the end, clinically useful findings were emphasized, important clinical and research issues were discussed, and directions for future treatment outcome studies were provided.
Improving harmonic spectrum of output voltage of a wind turbine with permanent magnet synchronous generator using Cuckoo optimization algorithm

In this paper, a fuzzy logic controller (FLC) is proposed for improving performance of power electronic inverter of the wind turbine with Permanent Magnet Synchronous Generator (PMSG). Membership functions of the fuzzy controller are adjusted using Cuckoo optimization algorithm (COA). Membership functions of the conventional methods are determined using trial and error method which is time consuming and does not give desirable result. The proposed method resolves these problems. In this paper, mean squared error of the output voltage is used as the objective function of the proposed algorithm. COA adjusts membership functions such that least MSE is provided for the output voltage of the inverter and performance of the wind turbine's output is improved in terms of amplitude and frequency. The proposed scheme is simulated in MATLAB. Simulation results show that the proposed controller presents desirable output voltage in the presence of linear and nonlinear loads. In addition, inverter has small error in the stable mode and its response is faster than reference changes.
A new computational method for the detection of horizontal gene transfer events

In recent years, the increase in the amounts of available genomic data has made it easier to appreciate the extent by which organisms increase their genetic diversity through horizontally transferred genetic material. Such transfers have the potential to give rise to extremely dynamic genomes where a significant proportion of their coding DNA has been contributed by external sources. Because of the impact of these horizontal transfers on the ecological and pathogenic character of the recipient organisms, methods are continuously sought that are able to computationally determine which of the genes of a given genome are products of transfer events. In this paper, we introduce and discuss a novel computational method for identifying horizontal transfers that relies on a gene's nucleotide composition and obviates the need for knowledge of codon boundaries. In addition to being applicable to individual genes, the method can be easily extended to the case of clusters of horizontally transferred genes. With the help of an extensive and carefully designed set of experiments on 123 archaeal and bacterial genomes, we demonstrate that the new method exhibits significant improvement in sensitivity when compared to previously published approaches. In fact, it achieves an average relative improvement across genomes of between 11 and 41% compared to the Codon Adaptation Index method in distinguishing native from foreign genes. Our method's horizontal gene transfer predictions for 123 microbial genomes are available online at .
Controlling factors of feed intake and salivary secretion in goats fed on dry forage

The purpose of this research was to determine whether or not feeding induced hypovolemia (decreases in plasma volume) and decreases in plasma bicarbonate concentration caused by loss of NaMCO 3 from the blood, act to suppress feed intake and saliva secretion volumes during the initial stages of feeding in goats fed on dry forage. The animals were fed twice a day at 10:30 and at 16:00 for 2 h each time. Prior to the morning feeding, the collected saliva (3-5 kg) was infused into the rumen. During the morning 2 h feeding period (10:30 to 12:30), the animals were fed 2-3 kg of roughly crushed alfalfa hay cubes. At 16:00, the animals were fed again with 0.8 kg of alfalfa hay cubes, 200 g of commercial ground concentrate and 20 g of sodium bicarbonate. In order to compensate for water or NaHCO 3 lost through saliva during initial stages of feeding, a 3 h intravenous infusion (17-19 ml/min) of artificial mixed saliva (ASI) or mannitol solution (MI) was begun 1 h prior to the morning feeding and continued until the conclusion of the 2 h feeding period. The physiological state of the goats in the present experiment remained unchanged after parotid gland fistulation. Circulating plasma volume decreases caused by feeding (estimated by increases in plasma total protein concentration) were significantly suppressed by the ASI and MI treatments. During the first 1 h of the 2 h feeding period, plasma osmolality in the ASI treatment was the same as the NI (non-infusion control) treatment, while plasma osmolality in the MI treatment was significantly higher. In comparison to the NI treatment, cumulative feed intake levels for the duration of the 2 h feeding period in the ASI and MI treatments increased markedly by 56.6 and 88.3%, respectively. On the other hand, unilateral cumulative parotid saliva secretion volume following the termination of the 2 h feeding period in the ASI treatment was 50.7% higher than that in the NI treatment. MI treatment showed the same level as the NI treatment. The results of the present experiment proved that the humoral factors involved in the suppression of feeding and saliva secretion during the initial stages of feeding in goats fed on dry forage, are feeding induced hypovolemia and decrease in plasma HCO 3 - concentration caused by loss of NaHCO 3 from the blood.
Modelling and control design for biped robot standing on nonstationary plane

Motion control of biped robots includes a variety of tasks, such as controlling a robot walking on a horizontal plane, climbing stairs, moving on uneven surfaces, etc. This article describes modeling and designed control system for a biped robot standing on nonstationary plane. The problem of stabilization of the balancing robot, assembled on the basis of a robotic kit Bioloid, is considered for the case, when trajectories of movable plane are assumed to be bounded and unknown in advance. In contrast to previous works [4], [8] the mathematical model of the system is completed with dynamical equations and an estimator of nonstationary plane angle and angular velocity is designed. Performance of the proposed control algorithm is confirmed by numerical simulation.
Stages of grammaticalization of causative verbs and constructions in Portuguese, Spanish, French and Italian

The article shows that analytic causative constructions are more grammaticalized in French and Italian than in Spanish and Portuguese, both in meaning (semantic bleaching of the verb ‘to make’) and in synthesis (structural event integration). It is pointed out, moreover, that Italian fare + infinitive is semantically and structurally more grammaticalized than French faire + infinitive, and that the emergence of the inflected infinitive in the clausal complements of causative and perception verbs in Portuguese has made the Portuguese causative constructions less integrated, and thus less grammaticalized, than the Spanish ones. The conclusion of this study is that there exists a decreasing continuum of grammaticalization of causative constructions in Romance languages, that starts with Italian and goes on to French, Spanish and Portuguese, in that order.
Temporal and geographical distribution of cases of foot-and-mouth disease during the early weeks of the 2001 epidemic in Great Britain

Estimates of the likely dates of infection of the early cases of the 2001 foot-and-mouth disease (FMD) epidemic indicate that at least 57 premises in 16 counties in Great Britain were infected before the first case was disclosed. Nationwide animal movement controls were imposed within three days of the first case being confirmed on February 20, when FMD was only known to be in two counties, and these controls limited its geographical spread. After the first few cases were confirmed, new cases were rapidly discovered, and the epidemic curve for the daily number of confirmed cases peaked five weeks later, 11 days later than the peak of the curve based on the estimated dates of infection. In the peak week, both curves showed an average daily number of 43 new cases. The estimated dates of infection are believed to be relatively unbiased for the early cases, for which they were derived from a known contact with infection. However, for the later cases they were estimated mainly from the age of the clinical signs of the disease, and were biased by species and other factors, a bias which would probably have made the estimated dates later than was in fact the case.
New signposts of massive star formation in the S235A-B region

Aims. We report on new aspects of the star-forming region S235AB revealed through high-resolution observations at radio and midinfrared wavelengths. Methods. Using the Very Large Array, we carried out sensitive observations of S235AB in the cm continuum (6, 3.6, 1.3, and 0.7) and in the 22 GHz water maser line. These were complemented with Spitzer Space Telescope Infrared Array Camera archive data to clarify the correspondence between radio and IR sources. We made also use of newly presented data from the Medicina water maser patrol, started in 1987, to study the variability of the water masers found in the region. Results. S235A is a classical HII region whose structure is now well resolved. To the south, no radio continuum emission is detected either from the compact molecular core or from the jet-like structure observed at 3.3 mm, suggesting emission from dust in both cases. We find two new compact radio continuum sources (VLA-1 and VLA-2) and three separate maser spots. VLA-1 coincides with one of the maser spots and with a previously identified IR source (M 1). VLA-2 lies towards S235B and represents the first radio detection from this peculiar nebula that may represent an ionized wind from a more evolved star. The two other maser spots coincide with an elongated structure previously observed within the molecular core in the C 34 S line. This structure is perpendicular to a bipolar molecular outflow observed in HCO + (1−0) and may trace the associated equatorial disk. The Spitzer images reveal a red object towards the molecular core. This is the most viable candidate for the embedded source originating the outflow and maser phenomenology. Conclusions. The picture emerging from these and previous data shows the extreme complexity of a small (≤0.5 pc) star-forming region where widely different stages of stellar evolution are present.
Microtubule-Associated Protein 1B Controls Directionality of Growth Cone Migration and Axonal Branching in Regeneration of Adult Dorsal Root Ganglia Neurons

During development, microtubule-associated protein 1B (MAP1B) is one of the earliest MAPs, preferentially localized in axons and growth cones, and plays a role in axonal outgrowth. Although generally downregulated in the adult, we have shown that MAP1B is constitutively highly expressed in adult dorsal root ganglia (DRGs) and associated with central sprouting and peripheral regeneration of these neurons. Mutant mice with a complete MAP1B null allele that survive until adulthood exhibit a reduced myelin sheath diameter and conductance velocity of peripheral axons and lack of the corpus callosum. Here, to determine the function of MAP1B in axonal regeneration, we used cultures of adult DRG explants and/or dissociated neurons derived from this map1b-/- mouse line. Whereas the overall length of regenerating neurites lacking MAP1B was similar to wild-type controls, our analysis revealed two main defects. First, map1b-/- neurites exhibited significantly (twofold) higher terminal and collateral branching. Second, the turning capacity of growth cones (i.e., “choice” of a proper orientation) was impaired. In addition, lack of MAP1B may affect the post-translational modification of tubulin polymers: quantitative analysis showed a reduced amount of acetylated microtubules within growth cones, whereas the distribution of tyrosinated or detyrosinated microtubules was normal. Both growth cone turning and axonal branch formation are known to involve local regulation of the microtubule network. Our results demonstrate that MAP1B plays a role in these processes during plastic changes in the adult. In particular, the data suggest MAP1B implication in the locally coordinated assembly of cytoskeletal components required for branching and straight directional axon growth.
The matrix has you: realizing slow motion in full-body virtual reality

While we perceive time as a constant factor in the real world, it can be manipulated in media. Being quite easy for linear media, this is used for various aspects of storytelling e.g., by applying slow motion in movies or TV. Interactive media like VR however poses additional challenges, because user interaction speed is independent from media speed. While it is still possible to change the speed of the environment, for interaction it is also necessary to deal with the emerging speed mismatch, e.g., by slowing down visual feedback of user movements. In this paper, we explore the possibility of such manipulations of visual cues, with the goal of enabling the use of slow motion also in immersive interactive media like VR. We conducted a user study to investigate the impact of limiting angular velocity of a virtual character in first person view in VR. Our findings show that it is possible to use slow motion in VR while maintaining the same levels of presence, enjoyment and susceptibility to motion sickness, while users adjust to the maximum speed quickly. Moreover, our results also show an impact of slowing down user movements on their time estimations.