Miracle-dz/UniFAR-FTUs huggingface dataset:
Forkhead Box M1 Regulates Quiescence-Associated Radioresistance of Human Head and Neck Squamous Carcinoma Cells

Cellular quiescence is a reversible growth arrest in which cells retain their ability to enter into and exit from the proliferative cycle. This study investigates the hypothesis that cell growth-state specific oxidative stress response regulates radiosensitivity of cancer cells. Results showed that quiescent (low proliferative index; >75% G1 phase and lower RNA content) Cal27 and FaDu human head and neck squamous cell carcinoma (HNSCC) are radioresistant compared to proliferating cells. Quiescent cells exhibited a three to tenfold increase in mRNA levels of Mn-superoxide dismutase (MnSOD), dual oxidase 2 (DUOX2) and dual-specificity phosphatase 1 (DUSP1), while mRNA levels of catalase (CAT), peroxiredoxin 3 (PRDX3) and C-C motif ligand 5 (CCL5) were approximately two to threefold lower compared to proliferating cells. mRNA levels of forkhead box M1 (FOXM1) showed the largest decrease in quiescent cells at approximately 18-fold. Surprisingly, radiation treatment resulted in a distinct gene expression pattern that is specific to proliferating and quiescent cells. Specifically, FOXM1 expression increased two to threefold in irradiated quiescent cells, while the same treatment had no net effect on FOXM1 mRNA expression in proliferating cells. RNA interference and pharmacological-based downregulation of FOXM1 abrogated radioresistance of quiescent cells. Furthermore, radioresistance of quiescent cells was associated with an increase in glucose consumption and expression of glucose-6-phosphate dehydrogenase (G6PD). Knockdown of FOXM1 resulted in a significant decrease in G6PD expression, and pharmacological-inhibition of G6PD sensitized quiescent cells to radiation. Taken together, these results suggest that targeting FOXM1 may overcome radioresistance of quiescent HNSCC.
A planar orthomode transducer for broadband applications at 25 GHz using a stepped waveguide technique

In this contribution, a novel planar orthomode transducer is presented. It is based on a stepped waveguide technique that makes the transducer small and easy to handle. Several electromagnetic simulations were performed in order to optimize the transducer's structure and to investigate possible production tolerances, respectively. The developed orthomode transducer was built up and measured in a back to back assembly. The broadband measurement results as well as its planar structure allow different kind of feeding which make the presented orthomode transducer suitable for numerous applications.
Effects of Al on epitaxial graphene grown on 6H-SiC(0001)

Aluminum was deposited on epitaxial monolayer-grown graphene on SiC(0001). The effects of annealing up to 1200 °C on the surface and interface morphology, chemical composition, and electron band structure were analyzed in situ by synchrotron-based techniques at the MAX Laboratory. After heating at around 400 °C, Al islands or droplets are observed on the surface and the collected Si 2p, Al 2p, and C 1s core levels spectra indicate Al intercalation at the graphene SiC interface. Also, the original single π-band splits into two, indicating decoupling of the carbon buffer layer and the formation of a quasi-free-standing bilayer-like electronic structure. Further heating at higher temperatures from 700 to 900 °C yields additional chemical reactions. Broader core level spectra are then observed and clear changes in the π-bands near the Dirac point are detected. More electron doping was detected at this stage since one of the π-bands has shifted to about 1.1 eV below the Fermi level. Different ordered phases of (7 × 7), (4 × 4), (1 × 1)Al, and (1 × 1)G were also observed on the surface in this temperature range. The original single π-band was restored after heating at ~1200 °C, although an Al signal was still able to be detected.
Time Pattern of Sperm Whale Codas Recorded in the Mediterranean Sea 19851996

Sperm whales, Physeter macrocephalus (= P. car&on), emit short click sequences, referred to as codas,’ with typical time patterns. Since codas recorded in different geographical areas have different and stable patterns, they possibly serve to convey regional information. More than 120 codas were recorded in the central Mediterranean Sea in the years 1985-1996. Nearly all of the recorded codas share the same “3+1” (/// /) time pattern with an overall duration ranging from 456 to 1280 ms and an average duration of 910 ms. Even if the coda duration varies, the click pattern remains significantly stable. In the present work, we characterize the repetition rate and time pattern of Mediterranean codas, also taking into consideration their possible biological and geographical role. INTRODUCTION Sperm whales, Physeter macrocephalus Linnaeus 1758, are well known to produce short click sequences, referred to as codas,’ with typical time patterns. Throughout the world’s oceans, several different temporal patterns of codas have been recorded and, although their function remains unclear, it has been suggested that they might be considered regional or group markers. ‘” Within a wide research project on the acoustic behaviors of cetaceans in the Mediterranean Sea, a large number of recordings of sperm whale sounds, now archived in a Cetacean Sound Library,’ were collected from multiple sources and analyzed. A total of 127 codas have been found and analyzed to characterize a pattern that may be typical of the Mediterranean Sea. MATERIALS AND METHODS The recordings were made in the central Mediterranean Sea by five research groups in the years 19851996 using a numberofdifferent detection instruments, including stationary and towed hydrophones as well as sonobuoys and passive sonars of the Italian Navy. Figure I (a) shows the recording sites. Inter-click interval (ICI) measurements, performedon the Digital Signal Processing Workstation (DSPW) developed at CIBRA, have an accuracyof ti ms. When possible, the lengths of the vocalizing whales were estimated by means of inter-pulse interval (IPI) measurements. ’
Delayed reaction urticaria due to trimebutine

1. Reinalter SC, Jeck N, Brochhausen C, Watzer B, Nusing RM, Seyberth HW et al. Role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome. Kidney Int 2002;62:253–260. 2. Patriarca G, Rossi M, Schiavino D, Schinco G, Fais G, Varano C et al. Rush desensitization in heparin hypersensitivity: a case report. Allergy 1994;49:292–294. 3. Nucera E, Schiavino D, Buonomo A, Del Ninno M, Sun JY, Patriarca G. Tolerance induction to cotrimoxazole. Allergy 2000;55:681–682. 4. Nucera E, Roncallo C, Masini L, Buonomo A, De Pasquale T, Pollastrini E et al. Successful tolerance induction to spiramycin in pregnancy. Scand J Infect Dis 2002;34:550–551.
Qualitative results of a structured group program for carers of people with frontotemporal dementia

Carer burden in frontotemporal dementia (FTD) is even higher than in Alzheimer’s Disease, with obvious implications for carer health and well-being. Although support groups are commonly recommended for carers, they target memory symptoms and may not meet the needs of FTD carers (Nicolaou et al., 2010). Research to date provides conflicting evidence of the efficacy for reducing burden in carers using provision of information, advice and support (Diehl et al., 2003). We report qualitative results on a structured program adapted specifically for FTD carers.
Site-specific Phosphorylation of Synapsin I by Mitogen-activated Protein Kinase and Cdk5 and Its Effects on Physiological Functions*

Posttranslational modifications of synapsin I, a major phosphoprotein in synaptic terminals, were studied by mass spectrometry. In addition to a well known phosphorylation site by calmodulin-dependent protein kinase II (CaM kinase II), a hitherto unrecognized site (Ser553) was found phosphorylated in vivo. The phosphorylation site is immediately followed by a proline, suggesting that the protein is an in vivo substrate of so-called proline-directed protein kinase(s). To identify the kinase involved, three proline-directed protein kinases expressed highly in the brain, i.e. mitogen-activated protein (MAP) kinase, Cdk5-p23, and glycogen synthase kinase 3β, were tested for the in vitro phosphorylation of synapsin I. Only MAP kinase and Cdk5-p23 phosphorylated synapsin I stoichiometrically. The phosphorylation sites were determined to be Ser551 and Ser553 with Cdk5-p23, and Ser62, Ser67, and Ser551 with MAP kinase. Upon phosphorylation with MAP kinase, synapsin I showed reduced F-actin bundling activity, while no significant effect on the interaction was observed with the protein phosphorylated with Cdk5-p23. These results raise the possibility that the so-called proline-directed protein kinases together with CaM kinase II and cAMP-dependent protein kinase play an important role in the regulation of synapsin I function.
Functionalization of BN nanotubes with dichlorocarbenes

The geometric and electronic structures of dichlorocarbene (CCl2) functionalized BN nanotubes (BNNTs) were studied using density functional theory within the generalized gradient approximation. We found that the CCl2 addition favors slanted B–N bonds in zigzag tubes, and the CCl2-attached BNNTs prefer open rather than closed three-membered-ring (3MR) structures in all the zigzag (n,0) BNNTs studied, whereas closed 3MR structure occurs in the CCl2-attached BN graphene layer. The binding energies decrease with increase of the CCl2 coverage, but the electronic properties of BNNTs do not change significantly, irrespective of the CCl2 coverage.
A novel online clustering-based object localization strategy using learnings and human interest priors

Moving object localization is a popular study in contemporary computer vision, provided the fact that many challenging problems, such as illumination changes, obstacles, object shape transformation, etc, are still to be deeply investigated and properly tackled in moving object localization for the time being. In this study, a new clustering-based strategy is introduced to realize the moving object localization task for the first time. The strategy is divided into two steps. First, a spatially-weighted isotropically-scaled Gaussian measure is adopted to reveal the pixel-wise similarity in each individual frame of a video clip or image sequence. This similarity measure aims to differentiate pixels belonging to the group of moving target object and others. A supervised spectral clustering technique is incorporated to determine the parametric form of the similarity measure, which is associated with the idea of incremental learning. Second, an unsupervised out-of-sample extension is incorporated to finalize the differentiation of pixels, in order to obtain localization outcomes, for the consideration of efficiency boosting. Our strategy has been evaluated based on a database composed of nearly 1000 frames, and compared with several well-known approaches in this moving object localization task. Promising results are demonstrated based on a series of statistical tests. It is suggested that the newly introduced strategy is superior towards other compared methods in this study.
Up and down frequency conversion of a QPSK signal by an all-optical radiofrequency sampling mixer based on a semiconductor optical amplifier Mach-Zehnder interferometer

An all-optical sampling mixer based on a Semiconductor Optical Amplifier Mach-Zehnder Interferometer is performed. The frequency properties of a sampled signal are exploited to obtain both up and down frequency conversion of QPSK data. The optical pulse source, generating 10-ps width pulses at the repetition rate of 7.8 GHz as a sampling signal, allows operation in the 0.5-39.5 GHz range. The conversion gain of the all-optical sampling mixer is measured over all the frequency range. It varies over this range from 20.4 to 0 dB for frequency down-conversion and from 15.5 to -13.4 dB for frequency up-conversion. QPSK data at symbol rates between 8 MSymb/s to 128 MSymb/s are frequency converted. The Error Vector Magnitude is used to evaluate the quality of the frequency conversion. Exploitable EVMs in the range 14 to 27.4% are reached for up-conversion operation to the higher frequency for all the symbol rates. For down-conversion the EVM varies from 6.7 to 29.2% at the symbol rate of 64 MSymb/s for all the frequency range.
High Performance Computing: CUDA as a Supporting Technology for Next Generation Augmented Reality Applications

The main purpose of this survey is presenting the potential of GPGPU technology for real time markerless augmented reality related processing. CUDA is a GPGPU technology developed by NVIDIA that allows programmers to use the C programming language to code algorithms for execution on the GPU. Applications that require mathematically intensive computation of large amounts of data are ideal targets for GPU computing. In this survey, CUDA architecture will be depicted, together with an optimized programming model for obtaining better results using the parallel approach. A case study, mainly related to tracking algorithms, will also be shown in order to demonstrate the performance improvement in comparison to sequential approaches.
Toxicokinetics of sulfur mustard and its DNA-adducts in the hairless guinea pig.

In order to provide a quantitative basis for pretreatment and therapy of intoxications with sulfur mustard (SM) the toxicokinetics of this agent as well as its major DNA-adduct were studied in male hairless guinea pigs for the intravenous, respiratory and percutaneous routes. The study comprised measurement of the concentration-time course of SM in blood and measurement of the concentrations of intact SM and its adduct to guanine in various tissues at several time points after administration of, or exposure to SM. SM was analyzed in blood and tissues by gas chromatography with automated thermodesorption injection and mass-spectrometric detection. DNA-adducts were measured via an immuno-slot-blot method. In contrast with nerve agents of the phosphofluoridate type, SM partitions strongly to various organs, especially the lung, spleen, liver and bone marrow. The respiratory toxicity of SM appears to be local, rather than systemic. Surprisingly, the maximum concentration of SM in blood upon percutaneous exposure to 1 LCt50 (10,000 mg.min.m-3, estimated) is approximately 6-fold higher than that for nose--only exposure to 3 LCt50 (2,400 mg.min.m-3). Pretreatment of hairless guinea pigs with the potential scavengers N-acetyl cysteine or cysteine isopropyl ester did not significantly increase the LCt50-value for nose--only exposure to SM vapor.
Microstructure characterization of erosion resistant coatings on carbon‐bonded carbon fibre composites

The microstructure of as received and surface treated carbon‐bonded carbon fibre composites has been examined by light microscopy, scanning and transmission electron microscopy. The microstructure of the as received material consists of a bonded together layered carbon fiber network, identified as graphitic carbon (hexagonal close packed). To improve the erosion resistance of the carbon‐bonded carbon fibre composites composite, the SiC and silicate glass–ceramic coatings from the system SiO2–Al2O3–Y2O3 were produced on carbon‐bonded carbon fibre composites composites by a low‐cost slurry technique. Transmission electron microscopy investigations of cross‐section thin foils allowed for detailed analysis of the coatings microstructure. It was found that the SiC coating was consisting mainly of a nanocrystalline SiC (fcc). The multilayered glass–ceramic coating showed a complex microstructure consisting of an external SiO2–Al2O3–Y2O3 layer and an intermediate nanocrystalline SiC layer. The SiO2–Al2O3–Y2O3 layer was composed of SiO2 (fcc), Y2Si2O7 (op) and Al4.644Si1. 357O9.68 (op).
Planning and SAT

The planning problem in Artificial Intelligence was the first application of SAT to reasoning about transition systems and a direct precursor to the use of SAT in a number of other applications, including bounded model-checking in computer-aided verification. This chapter presents the main ideas about encoding goal reachability problems as a SAT problem, including parallel plans and different forms of constraints for speeding up SAT solving, as well as algorithms for solving the AI planning problem with a SAT solver. Finally, more general planning problems that require the use of QBF or other generalizations of SAT are discussed.
BALANCED BUDGETS AND BUSINESS CYCLES: EVIDENCE FROM THE STATES

This paper presents evidence that stringent balanced budget requirements enforced in some U.S. states have exacerbated business cycles in those states. The effect is not apparent directly. However, among states where fiscal policy may have more macroeconomic consequences (large states), the difference in volatility between states with lenient and strict balanced budget rules is larger (more negative or less positive) than among states where fiscal policy may be less relevant (small states). Two implications are suggested: (1) states' fiscal policies have real macroeconomic consequences, and (2) strict balanced budget requirements increase business cycle volatility.
An improved multicast routing algorithm in sparse splitting optical networks

The construction of multicast light-trees in WDM network with sparse splitting has been proved to be an NP-complete problem. To reduce the diameter of the tree and average delay, an improved algorithm called Nearest Connector First Heuristic (NCFH) is proposed. The simulation results show that the proposed algorithm performs well.
Network Science @ Recommender Systems

We present a conceptual approach in the field of r ecommender systems, which is intended to model human consumpti on by maintaining a network of heterogeneous nodes and relationships. W e think of this model as the reflection of the corresponding cognitive funct ionality of human thinking, as we maintain a structure which is similar to the structures established by neural networks. To explain our motivation and the proposed structure we are combining the results of recommender systems and ne twork science. We propose a generalized approach that intends to invo lve concepts from social networks, semantic distance, association rule minin g, o tological modeling and expert systems. Our approach will access and integr at different information sources, modeling also additional information types . We expect that our approach will find the importance factors of the af orementioned information sources for the generation of high quality recommen dations.
A leakage reduced HVIC with coarse-fine UVLO

This paper presents a leakage reduced HVIC using coarse-fine UVLO deploying a coarse UVLO to minimize current consumption of the fine UVLO in idling mode, which overcomes the disadvantage of conventional high side UVLO in HVIC. The proposed HVIC is implemented in 0. 5μm Fairchild HDG4D 650V CMOS process. The total current consumption of HVIC including coarse-fine UVLO at 3V power supply is 1μA, which is 10 times smaller current consumption than HVIC with conventional high side UVLO.
Icon Set Selection via Human Computation

Picking the best icons for a graphical user interface is difficult. We present a new method which, given several icon candidates representing functionality, selects a complete icon set optimized for comprehensibility and identifiability. These two properties are measured using human computation. We apply our method to a domain with a less established iconography and produce several icon sets. To evaluate our method, we conduct a user study comparing these icon sets and a designer-picked set. Our estimated comprehensibility score correlate with the percentage of correctly understood icons, and our method produces an icon set with a higher comprehensibility score than the set picked by an involved icon designer. The estimated identifiability score and related tests did not yield significant findings. Our method is easy to integrate in traditional icon design workflow and is intended for use by both icon designers, and clients of icon designers.
Extended latent class approach to the study of familial/sporadic forms of a disease: Its application to the study of the heterogeneity of schizophrenia

When no method exists for detecting genetic forms of a disorder, epidemiologists classify probands according to the presence or absence of an affected relative (familial or sporadic). Not only is this a surrogate measure but if the risk for the disorder is associated with characteristics such as age and gender, then probands with varied distributions of these characteristics among their relatives are subject to misclassification. A latent class approach is presented which explicitly models the relationship between the affected status of the relatives and the unobservable familial/sporadic status of the proband in order to adjust for these characteristics. Lastly, an approach is introduced to correct for attenuation in measures of association between familial/sporadic status and other variables that could result if probands are misclassified. This approach incorporates the latent class probabilities directly into the regression model without classifying probands. These methods are applied to a study of theheterogeneity of schizophrenia.
Probing an adhesion mutant of Dictyostelium discoideum with cDNA clones and monoclonal antibodies indicates a specific defect in the contact site A glycoprotein

Expression of developmentally regulated membrane proteins of aggregating cells of Dictyostelium discoideum is subject to several control mechanisms. One of them involves periodic cyclic‐AMP pulses as signals for gene expression. To increase the probability of selecting mutants specifically defective in the contact site A (csA) glycoprotein, one of the characteristic proteins of aggregating cells, we have bypassed the requirement for both cyclic‐AMP pulses and another control element by two runs of mutagenesis. A ‘double bypass’ mutant, HG592, was obtained which aggregated in nutrient medium where wild‐type did not develop. Mutants defective in expression of the csA‐glycoprotein were selected from HG592 by fluorescence‐activated cell sorting and colony immunoblotting using a monoclonal antibody specific for that protein. One among 51 csA‐negative mutants, HG693, specifically lacked the capability of forming EDTA‐stable intercellular contacts. It acquired chemotactic responsiveness and developed into fruiting bodies. Expression of the transcripts for eight developmentally regulated proteins was determined in HG693. Seven of the RNA species were normally expressed; they were recognized by cDNA clones which had been produced from poly(A)+ RNA isolated from membrane‐bound polysomes. The single RNA species which was not substantially expressed in HG693 was recognized by a cDNA clone that was obtained by screening a λgt11 library with an antibody specific for the csA‐glycoprotein. When probing RNA from wild‐type cells, this clone hybridized with a single developmentally regulated RNA species of 1.9 kb whose expression was strongly enhanced by cyclic‐AMP pulses. Appearance of this RNA coincided with the expression of the csA‐glycoprotein.