Miracle-dz/UniFAR-FTUs huggingface dataset:
Advances in Asphaltene Science and the Yen–Mullins Model

The Yen–Mullins model, also known as the modified Yen model, specifies the predominant molecular and colloidal structure of asphaltenes in crude oils and laboratory solvents and consists of the following: The most probable asphaltene molecular weight is ∼750 g/mol, with the island molecular architecture dominant. At sufficient concentration, asphaltene molecules form nanoaggregates with an aggregation number less than 10. At higher concentrations, nanoaggregates form clusters again with small aggregation numbers. The Yen–Mullins model is consistent with numerous molecular and colloidal studies employing a broad array of methodologies. Moreover, the Yen–Mullins model provides a foundation for the development of the first asphaltene equation of state for predicting asphaltene gradients in oil reservoirs, the Flory–Huggins–Zuo equation of state (FHZ EoS). In turn, the FHZ EoS has proven applicability in oil reservoirs containing condensates, black oils, and heavy oils. While the development of the Yen–Mullin.
Draft Genome Sequence of the Actinomycete Rhodococcus sp. Strain AW25M09, Isolated from the Hadsel Fjord, Northern Norway

ABSTRACT The cold-adapted Rhodococcus sp. strain AW25M09 was isolated from an Atlantic hagfish caught off the shore of northern Norway as part of an ongoing bioprospecting project that aims to identify novel bacteria with biotechnological potential. Here, we present the 5.8-Mb draft genome sequence, together with details regarding the origin of the strain and its sequence assembly.
The Spiral of Silence Ten Years Later: An Examination and Evaluation.

ABSTRACT In her model of opinion formation, Elizabeth Noelle-Neumann postulates a spiral of silence:,to avoid isolation, people holding minority views either alter their ideas to conform to the majority's stance or remain silent, thus increasing the impression of the majority view's dominance. While providing,a helpful integration of disparate ideas in public opinion formation, Noelle-Neumann's framework has been questioned at a number of poipts. Is it reasonable to assume that since people fear isolation, most fear being in the minority? Research suggests, in fact, that many people can, oppose majority views as long as they have individual or group support and that interpersonal relationships have a greater impact on opinion formation than impersonal public opinion presented via the media. Recent studies have also offered an alternative to Noelle-Neumann's view of people as simply 'reacting to their perception of public opinion, suggesting that instead, people use their own opinions to form their perceptions of public attitudes. Whether people's behavior resembles the reaction or projection model may depend on a numben of conditions, including their familiaritywith the issue. Further research is needed on the many factors influencing opinion formation. (MM)
Network Configuration Protocol (NETCONF)

The Network Configuration Protocol (NETCONF) defined in this document provides mechanisms to install, manipulate, and delete the configuration of network devices. It uses an Extensible Markup Language (XML)-based data encoding for the configuration data as well as the protocol messages. The NETCONF protocol operations are realized as remote procedure calls (RPCs). This document obsoletes RFC 4741. [STANDARDS-TRACK]
The acute versus the chronic response to exercise.

PURPOSE There is strong and consistent evidence that a single exercise session can acutely reduce triglycerides and increase high-density lipoprotein (HDL) cholesterol (HDL-C), reduce blood pressure, and improve insulin sensitivity and glucose homeostasis. Such observations suggest that at least some of the effects on atherosclerotic cardiovascular disease (ASCVD) risk factors attributed to exercise training may be the result of recent exercise. RESULTS These acute and chronic exercise effects cannot be considered in isolation. Exercise training increases the capacity for exercise, thereby permitting more vigorous and/or more prolonged individual exercise sessions and a more significant acute effect. The intensity, duration, and energy expenditure required to produce these acute exercise effects are not clearly defined. The acute effect of exercise on triglycerides and HDL-C appears to increase with overall energy expenditure possibly because the effect maybe mediated by reductions in intramuscular triglycerides. Prolonged exercise appears necessary for an acute effect of exercise on low-density lipoprotein (LDL) cholesterol (LDL-C) levels. The acute effect of exercise on blood pressure is a low threshold phenomenon and has been observed after energy expenditures requiring only 40% maximal capacity. The acute effect of exercise on glucose metabolism appears to require exercise near 70% maximal, but this issue has not been carefully examined. CONCLUSIONS Exercise has definite acute effects on blood lipids, blood pressure, and glucose homeostasis. Exercise also has acute effects on other factors related to atherosclerosis such as immunological function, vascular reactivity, and hemostasis. Considerable additional research is required to define the threshold of exercise required to produce these putatively beneficial effects.
A practical study of neural network-based image classification model trained with transfer learning method

This paper deals with algorithms for image classification, which aim to guess “what is on the picture” using human-readable labels or categories. A supervised learning approach with Convolutional Neural Networks (CNNs) is studied as an effective solution to different computer vision problems, including image classification. Main contribution of this paper is a set of practical guidelines to tackle the image classification problem using publicly available tools and typical hardware platforms.
Dynamic output feedback control of a flexible air-breathing hypersonic vehicle via T–S fuzzy approach

By utilising Takagi–Sugeno (T–S) fuzzy set approach, this paper addresses the robust H∞ dynamic output feedback control for the non-linear longitudinal model of flexible air-breathing hypersonic vehicles (FAHVs). The flight control of FAHVs is highly challenging due to the unique dynamic characteristics, and the intricate couplings between the engine and fight dynamics and external disturbance. Because of the dynamics’ enormous complexity, currently, only the longitudinal dynamics models of FAHVs have been used for controller design. In this work, T–S fuzzy modelling technique is utilised to approach the non-linear dynamics of FAHVs, then a fuzzy model is developed for the output tracking problem of FAHVs. The fuzzy model contains parameter uncertainties and disturbance, which can approach the non-linear dynamics of FAHVs more exactly. The flexible models of FAHVs are difficult to measure because of the complex dynamics and the strong couplings, thus a full-order dynamic output feedback controller is designed for the fuzzy model. A robust H∞ controller is designed for the obtained closed-loop system. By utilising the Lyapunov functional approach, sufficient solvability conditions for such controllers are established in terms of linear matrix inequalities. Finally, the effectiveness of the proposed T–S fuzzy dynamic output feedback control method is demonstrated by numerical simulations.
Evidence for cardiac safety and antiarrhythmic potential of chloroquine in systemic lupus erythematosus.

AIMS To perform a comprehensive evaluation of heart rhythm disorders and the influence of disease/therapy factors in a large systemic lupus erythematosus (SLE) cohort. METHODS AND RESULTS Three hundred and seventeen consecutive patients of an ongoing electronic database protocol were evaluated by resting electrocardiogram and 142 were randomly selected for 24 h Holter monitoring for arrhythmia and conduction disturbances. The mean age was 40.2 ± 12.1 years and disease duration was 11.4 ± 8.1 years. Chloroquine (CQ) therapy was identified in 69.7% with a mean use of 8.5 ± 6.7 years. Electrocardiogram abnormalities were detected in 66 patients (20.8%): prolonged QTc/QTd (14.2%); bundle-branch block (2.5%); and atrioventricular block (AVB) (1.6%). Age was associated with AVB (P = 0.029) and prolonged QTc/QTd (P = 0.039) whereas anti-Ro/SS-A and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores were not (P > 0.05). Chloroquine was negatively associated with AVB (P = 0.01) as was its longer use (6.1 ± 6.9 vs. 1.0 ± 2.5 years, P = 0.018). Time of CQ use was related with the absence of AVB [odds ratio (OR) = 0.103; 95% confidence interval (CI) = 0.011-0.934, P = 0.043] in multiple logistic regression. Holter monitoring revealed abnormalities in 121 patients (85.2%): supraventricular ectopies (63.4%) and tachyarrhythmia (18.3%); ventricular ectopies (45.8%). Atrial tachycardia/fibrillation (AT/AF) were associated with shorter CQ duration (7.05 ± 7.99 vs. 3.63 ± 5.02 years, P = 0.043) with a trend to less CQ use (P = 0.054), and older age (P < 0.001). Predictors of AT/AF in multiple logistic regression were age (OR = 1.115; 95% CI = 1.059-1.174, P < 0.001) and anti-Ro/SS-A (OR = 0.172; 95% CI = 0.047-0.629, P = 0.008). CONCLUSIONS Chloroquine seems to play a protective role in the unexpected high rate of cardiac arrhythmias and conduction disturbances observed in SLE. Further studies are necessary to determine if this antiarrhythmic effect is due to the disease control or a direct effect of the drug.
Two new species of betatorqueviruses identified in a human melanoma that metastasized to the brain

The role of viral infections in the etiology of brain cancer remains uncertain. Prior studies mostly focused on transcriptome or viral DNA integrated in tumor cells. To investigate for the presence of viral particles, we performed metagenomics sequencing on viral capsid-protected nucleic acids from 12 primary and 8 metastatic human brain tumors. One brain tumor metastasized from a skin melanoma harbored two new human anellovirus species, Torque teno mini virus Emory1 (TTMV Emory1) and Emory2 (TTMV Emory2), while the remaining 19 samples did not reveal any exogenous viral sequences. Their genomes share 63-67% identity with other TTMVs, and phylogenetic clustering supports their classification within the Betatorquevirus genus. This is the first identification of betatorqueviruses in brain tumors. The viral DNA was in its expected non-integrated circular form, and it is unclear if the viruses contributed to tumor formation. Whether the viruses originated from blood, or the primary skin tumor could not be ascertained. Overall, our results demonstrate the usefulness of viral metagenomics to detect previously unknown exogenous virus in human brain tumors. They further suggest that active viral infections are rare events in brain tumors, but support a follow-up larger scale study to quantify their frequency in different brain tumor subtypes.
Adaptive Transmission Rate With a Fixed Threshold Decoder for Diffusion-Based Molecular Communication

In this paper, a simple memory limited transmitter for molecular communication is proposed, in which information is encoded in the emission rate of the molecules. Taking advantage of memory, the proposed transmitter reduces the ISI problem by properly adjusting its emission rate, which can be interpreted as water-filling on the expected interference. The error probability of the proposed scheme is derived and the result is compared with the error probability of the optimal transmitter obtained by dynamic programming methods. Furthermore, for the special case of channel with one symbol memory, a tight lower bound on error probability is derived. Numerical results show that the performance of introduced transmitter is near optimal. Simplicity is the key feature of the presented communication system: the transmitter follows a simple rule, the receiver is a simple threshold decoder, and only one type of molecule is used to convey the information.
Persistent angina pectoris in a 17‐year‐old patient

Remarkable symptoms of angina pectoris during exercise in a young girl were first treated with diltiazem 60 mg t.i. d. The history of the patient showed an operation on coarctatcio aortae 11 months after birth. Seven years later, she underwent a second operation for a re‐implantation of the left main track (LMT) into the aortic root in the presence of Bland‐White‐Garland‐Syndrome. In order to elucidate morphological aspects a heart catheterization was performed because of persistent and increasing symptoms. Figure Figure 1 illustrates an unusual high re‐implantation site of the LMT and in accordance with this; a LMT‐bending of nearly 90° could be demonstrated. Intravascular ultrasound (IVUS) clearly visualized an additional compression of the LMT during every heart cycle at the bended site (Figures Figure 2 and Figure 3). After implantation of a paclitaxel eluting stent (DES; 3.0/8 mm), a normal angiographic aspect occurred (Figure Figure 4). Three months later the patient was free of symptoms at rest and under stress echo conditions. A six months angiographic follow‐up confirmed a perfect long‐term result (Figure Figure 5). Figure 1 Aortic root with re-implanted LMT. Bending of LMT at the origin. Figure 2 IVUS at the bent site of LMT, diastole. Figure 3 IVUS at the bent site of LMT, systole. Figure 4 After stent implantation. Figure 5 Six months angiographic follow‐up. We suggest that the longitudinal growing of our patient was the main reason for the development of the bending at the origin of LMT. Those patients with symptoms of angina pectoris and with re‐implanted coronary arteries should undergo angiographic evaluation along with IVUS. In the era of DES, a satisfying option for treatment is available with very promising long‐term results.
You Just Don T Understand Women And Men In Conversation

Thank you for reading you just don t understand women and men in conversation. As you may know, people have search numerous times for their chosen readings like this you just don t understand women and men in conversation, but end up in infectious downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they juggled with some harmful virus inside their desktop computer.
Resident Cell Chemokine Expression Serves as the Major Mechanism for Leukocyte Recruitment During Local Inflammation

The mechanistic relationships between initiating stimulus, cellular source and sequence of chemokine expression, and leukocyte recruitment during inflammation are not clear. To study these relationships in an acute inflammatory process, we challenged a murine air pouch with carrageenan. A time-dependent increase in TNF-α, monocyte chemottractant protein-1 (MCP-1), macrophage-inflammatory protein-1α (MIP-1α), RANTES, KC, and MIP-2 was found in the exudates preceding cell recruitment, but displaying different kinetic profiles. Air pouches generated for 2, 6, or 9 days before initiating inflammation demonstrated a proportional increase in the number of cells lining the cavities. Two hours after carrageenan stimulation, the synthesis of TNF-α and all chemokines but RANTES increased in proportion to the lining cellularity, although no differences in infiltrating leukocytes were found, suggesting that the early source of these mediators is resident cells. To assess the contribution of neutrophils to chemokine synthesis at later time points, we used neutropenic animals. Neutrophil depletion caused a decrease in TNF-α (51%), KC (37%), MIP-1α (30%), and RANTES (57%) levels and a 2-fold increase in monocytes 4 h after challenge. No effect on MIP-2 and MCP-1 levels was observed. The selective blockade of CXCR2 or CCR1 inhibited neutrophil recruitment by 74% and 54%, respectively, without a significant inhibition of monocytes. A differential effect on TNF-α and MCP-1 levels was observed after these treatments, indicating that the two receptors did not subserve a mere redundant chemotactic role. Overall, our results suggest that chemokines synthesized by resident cells play an important role in the evolution of the inflammatory response.
Collaboration with joint supply contracts in a two-stage textile-apparel supply chain

Textile and apparel industries are a typical seasonal business involving unpredictable variation in market. In order to get survived, forming supply chain and utilizing the emerged technology to establish a coordinated system become as an important common practice for enterprises in terms of cost reduction and efficiency improvement. Fundamental to this coordination is the management of the incentives of disparate supply chain participants including fabric suppliers, garments manufacturers, and apparel retailers, and others. This paper presents how contractual agreements between firms can impact their ability to efficiently coordinate operational decisions. A collaboration mechanism in a two-stage textile-apparel supply chain was discussed with two kinds of contracts: revenue sharing contracts and buy back contracts. The fabric supplier and the manufacturer enter a revenue sharing contract, and the retailer and manufacturer adopts the buy back contracts. Under the revenue sharing, the manufacturer shares a portion of the selling price to the supplier in return for a lower wholesale price. Under the buy-back contract, the garment manufacturer agrees to buy back unsold goods from the retailer for some agree-upon price.
STRATEGY AND STRATEGIC MANAGEMENT ACCOUNTING: AN INVESTIGATION OF ORGANIZATIONAL CONFIGURATIONS Authors:

The study examines the alignment and effectiveness of strategic choice and strategic management accounting (SMA) system design configurations. Six configurations were derived empirically deploying a cluster analysis of data collected from a sample of 193 large Slovenian companies. The first four clusters appear to provide some support for the central configurational proposition that higher levels of vertical and horizontal configurational alignments are associated with higher levels of performance. Evidence that contradicts the theory is also apparent, however, as the remaining two clusters exhibit high degrees of SMA vertical and horizontal alignment, but low performance levels. A discussion is provided suggesting that this latter observation might result from the final two clusters failing to develop strategic postures that are compatible to the radically changed business context that has arisen since the replacement of the centrally controlled economy with a market economy in Slovenia. STRATEGY AND STRATEGIC MANAGEMENT ACCOUNTING: AN INVESTIGATION OF ORGANIZATIONAL CONFIGURATIONS
Growth inhibitory effect of the human NIT2 gene and its allelic imbalance in cancers

The mammalian nitrilase (Nit) protein is a member of the nitrilase superfamily whose function remains to be characterized. We now show that the nitrilase family member 2 gene (NIT2) is ubiquitously expressed in multiple tissues and encodes protein mainly distributed in the cytosol. Ectopic expression of Nit2 in HeLa cells was found to inhibit cell growth through G2 arrest rather than by apoptosis. Consistent with this, proteomic and RT‐PCR analyses showed that Nit2 up‐regulated the protein and mRNA levels of 14‐3‐3σ, an inhibitor of both G2/M progression and protein kinase B (Akt)‐activated cell growth, and down‐regulated 14‐3‐3β, a potential oncogenic protein. Genotype analysis in four types of primary tumor tissues showed 12.5–38.5% allelic imbalance surrounding the NIT2 locus. The results demonstrated that NIT2 plays an important role in cell growth inhibition and links to human malignancies, suggesting that Nit2 may be a potential tumor suppressor candidate.
Measurement of the de Sitter precession of the Moon: A relativistic three-body effect.

Lunar laser-ranging data, accumulated between 1970 and 1986, are analyzed to estimate the deviation of the precession of the moon's orbit from the predictions of general relativity. No deviation from this predicted de Sitter precession rate of nearly 2 angular sec per century (sec/cy) is found, to within an estimated standard error of 0.04 sec/cy. This standard error, 2 percent of the predicted effect, incorporates an assessment of the likely contributions of systematic errors, and is about threefold larger than the statistical standard error.
Expression of Arabidopsis TOL genes

A strict control of abundance and localization of plasma membrane proteins is essential for plants to be able to respond quickly and accurately to a changing environment. The proteins responsible for the initial recognition and concentration of ubiquitinated plasma membrane proteins destined for degradation, are well characterized in mammals and yeast,1 yet no clear orthologs were found in plants.2 Recently, we have identified a family of proteins in higher plants, which function in vacuolar targeting and subsequent degradation of ubiquitinated plasma membrane proteins3,4 termed TOM1-like (TOL) proteins.
Combinatorial gene therapy for bone regeneration: Cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7

Bone morphogenetic proteins (BMPs) have demonstrated effectiveness as bone regeneration agents whether delivered as recombinant proteins or via gene therapy. Current gene therapy approaches use vectors expressing single BMPs. In contrast, multiple BMPs are coordinately expressed during bone development and fracture healing. Furthermore, BMPs likely exist in vivo as heterodimeric molecules having enhanced biological activity. In the present study, we test the hypothesis that gene therapy‐based bone regeneration can be enhanced by expressing combinations of BMPs. For in vitro studies, mesenchymal cell lines were transduced with individual adenoviruses containing BMP2, 4, or 7 cDNA under control of a CMV promoter (AdBMP2, 4, 7) or virus combinations. Significantly, combined transduction with AdBMP2 plus AdBMP7 or AdBMP4 plus AdBMP7 resulted in a synergistic stimulation of osteoblast differentiation. This synergy is best explained by formation of BMP2/7 and 4/7 heterodimers. To test in vivo biological activity, fibroblasts were transduced with specific virus combinations and implanted into C57BL6 mice. Consistent with in vitro results, strong synergy was observed using combined AdBMP2/BMP7 treatment, which induced twofold to threefold more bone than would be predicted based on the activity of individual AdBMPs. These studies show that dramatic enhancement of osteogenesis can be achieved using gene therapy to express specific combinations of interacting regenerative molecules. © 2005 Wiley‐Liss, Inc.