Miracle-dz/UniFAR-FTUs huggingface dataset:
Neoadjuvant human epidermal growth factor receptor-2 targeted therapy in patients with locally advanced breast cancer

Purpose We analyzed the responses of patients with locally advanced breast cancer to neoadjuvant chemotherapy (NAC) and NAC combined with neoadjuvant human epidermal growth factor receptor-2 (HER2) targeted therapy (NCHTT). Methods We retrospectively reviewed 59 patients with HER2 amplified locally advanced breast cancer among patients who were treated surgically after neoadjuvant therapy at Samsung Medical Center between 2005 and 2009. Thirty-one patients received conventional NAC and 28 patients received NCHTT. Pathologic responses were assessed according to response evaluation criteria in solid tumors (RECIST) guidelines. Results Pathologic complete response (pCR) was achieved in 13 out of 28 patients treated with NCHTT and in 6 out of 31 patients treated with NAC alone (46.4% vs. 19.4%, respectively, P = 0.049). Breast conserving surgery (BCS) was more frequently performed in the NCHTT group than in the NAC only group (71.4% vs. 19.4%, P < 0.001). The 3-year recurrence-free survival (RFS) rate was 100% in the NCHTT group and 76.4% in the NAC group (P = 0.014). Together, NCHTT, type of operation (BCS vs. mastectomy) and pathologic nodal status were significant prognostic factors for RFS in univariate analysis. Conclusion We found that NCHTT produced higher pCR rates than NAC alone in locally advanced breast cancer.
Affective well‐being and within‐day beliefs about job demands' influence on work performance: An experience sampling study

Affective well-being is influenced by individuals' momentary beliefs concerning events' impact on goals. We examined within-day beliefs concerning problem-solving demands' adverse impact on an important work goal (work performance). Participants (N = 68) provided data up to four times per day for one working week. Hourly beliefs about problem-solving demands' adverse impact on performance were associated with end-of-hour anxious affect and inversely associated with end-of-hour motivated pleasant affect. Practitioner Points Jobs cannot be treated as static entities with fixed characteristics that are interpreted in the same way by all people all of the time. In addition to environmental factors, job redesign interventions to enhance psychological well-being need to integrate information about dynamic, cognitive processes internal to the person and within-day temporal processes.
The weekend matters: Relationships between stress recovery and affective experiences

Non-work experiences during the weekend provide opportunities to recover from work demands and to replenish lost resources. This longitudinal study examined how specific recovery experiences during the weekend (relaxation, mastery, control, and detachment), as well as non-work hassles, were associated with specific positive and negative affective states during the following workweek. Participants (N 1⁄4 229) completed surveys before the week- end, during the weekend, and during the following workweek. Hierarchical regression analyses revealed that after controlling for affective states the previous week, recovery experiences during the weekend significantly explained variance in affective states at the end of the weekend and during the following workweek. Suggestions for future research include a closer examination of the role of individual differences, self-regulation, and specific work demands in employee stress recovery.
Identification of a Novel Basic Helix-Loop-Helix Gene, Heslike, and Its Role in GABAergic Neurogenesis

Neuronal subtype specification depends on multiple transcription factors such as basic helix-loop-helix (bHLH) factors. However, transcription factor codes for most neurons remain to be determined. Here, we report identification of a novel mouse bHLH factor, termed Heslike, that has Hes1-like bHLH domain and transcriptional repressor activity. Heslike is coexpressed with the bHLH factor Mash1 in brain regions that give rise to GABAergic neurons. In the mesencephalon and the caudal diencephalon, coexpression of Heslike and Mash1 is initially restricted to small regions but expanded dorsally from embryonic day 9.5 onward, and this expansion of coexpression is followed by GABAergic neurogenesis. Misexpression of Heslike in mouse embryos generates ectopic GABAergic neurons only from the Mash1+ region. In contrast, in the mesencephalon and the caudal diencephalon of Mash1-null mice, GABAergic neurons are almost completely missing and, instead, other neurons are generated, although Heslike is still expressed. Furthermore, coexpression of Heslike and Mash1 significantly promotes formation of GABAergic neurons, compared with each gene alone, in neural precursor cell culture. Thus, Heslike or Mash1 alone is not sufficient, but their coexpression may be important for generation of GABAergic neurons. These results suggest that combinations of distinct bHLH factors promote formation of distinct neuronal subtypes, thereby increasing neuronal diversity.
Neural Differences in Bilingual Children's Arithmetic Processing Depending on Language of Instruction

Many children in bilingual regions follow lessons in a language at school (school-language) that they hardly ever speak at home or in other informal settings. What are the neural effects of this phenomenon? This functional magnetic resonance imaging (fMRI) study investigates the effects of using school-language on brain activity during a high cognitive task in two groups of French/Dutch bilingual children. Participants were asked to assess the correctness of 3-operand (e.g., 5 - 2 = 3) and 4-operand (e.g., 3 - 2 = 1 + 4) equations, respectively. Instructions about the task were given either in the children's school-language or in another language that they only used at home. It was found that although both groups recruited a visuomotor occipitofrontal network in the left hemisphere, the children who performed the task in their school-language showed less activation than the children who did not, indicating the importance of language of instruction for bilingual children's arithmetic processing. © 2011 The Authors. Journal Compilation © 2011 International Mind, Brain, and Education Society and Blackwell Publishing, Inc.
Terminal values and meaning in life among university students with varied levels of altruism in the present period of socio-cultural change

Abstract The author of this paper, interested in the issues of values preference, meaning in life and altruism among university students has attempted to show a relation between them in the present period of clearly noticeable socio-cultural change. The study was conducted in 2009-2010 in Kraków among university students. The age of the respondents ranged from 21 to 25. 200 sets of correctly completed questionnaires were used for the results analysis. In order to show values preference among university students Rokeach’s ValueSurvey (RVS) was used. The level of a sense of meaning in life was measured by means of Crumbaugh and Maholick’s Purpose in Life Test (PLT). Moreover, Śliwak’s Questionnaire of Altruism (A-N) was applied to measure the level of altruism. It was found that students with a high level of altruism are accompanied by a higher level of meaning in life than students with a low level thereof. Terminal values significantly correlate with meaning in life in groups of students with a high and low level of altruism. Among terminal values, values personal in character appear to be more strongly related to meaning in life than values social in character.
Differential induction of apoptosis by fludarabine monophosphate in leukemic B and normal T cells in chronic lymphocytic leukemia.

Fludarabine (F-ara-A), an adenine nucleoside analog with efficacy in B-cell chronic lymphocytic leukemia (B-CLL), has also been shown to have a long-lasting suppressive effect on T lymphocytes. In heterogeneous clinical samples, apoptosis cannot be detected by standard methods in small cellular subsets. We developed, therefore, a combined assay of in situ end-labeling of nicked DNA by terminal deoxynucleotide transferase, with measurements of cellular DNA content and surface antigens (CD3, CD4, CD8, and CD19) by multiparametric flow cytometry. This assay was used to determine F-ara-A-induced apoptosis in different lymphocyte subsets from CLL patients and normal controls treated with F-ara-A in vitro. Apoptosis was also correlated to bcl-2 protein levels. We observed a direct effect of F-ara-A on both B-CLL and T lymphocytes. The response to F-ara-A in B-CLL lymphocytes in vitro was Rai stage-dependent, the early-stages being more responsive (P = .01). Higher levels of spontaneous apoptosis were observed in B-CLL lymphocytes from early stage patients (P = .02). No difference was observed in spontaneous apoptosis of normal T cells in B-CLL, although T lymphocytes in late-stage disease were more sensitive to F-ara-A-induced apoptosis. Incubation with cyclosporin A did not affect B-CLL and T-lymphocyte survival compared with control cultures. Results suggested a direct apoptotic effect of F-ara-A on B-CLL lymphocytes that decreases with increasing clinical stage. No correlation was found between bcl-2 and spontaneous or F-ara-A-induced apoptosis. Apoptosis occurred at all cell-cycle stages and was not restricted to cells in S phase. The mechanisms of this stage-dependent apoptosis in CLL remain to be elucidated.
A Methodology for Deriving OWL Ontologies from Products and Services Categorization Standards

Products and services categorization standards (PSCS), like UNSPSC, eCl@ss, eOTD, or the RosettaNet Technical Dictionary (RNTD) form a valuable set of concepts from the product and services domain and reflect some degree of consensus. They are thus a promising foundation for the creation of products and services ontologies. Existing approaches for this task, however, do neither properly reflect the specific semantics of the respective categorization standards, nor do they sufficiently address the high versioning dynamics due to product innovation. This paper presents a comprehensive approach for the proper reuse of such standards in product ontologies
Comparison of Freelite™ and N Latex serum free light chain assays in subjects with end stage kidney disease on haemodialysis

Abstract Background: Quantification of serum free light chains (FLC) is important in the diagnosis of plasma cell diseases where an abnormal kappa:lambda ratio infers a population of monoclonal plasma cells. The Freelite™ and N Latex assays have been validated in populations without kidney disease but there is a paucity of data relating to the use of these assays in end stage kidney disease (ESKD). The aim of the study was to compare FLC assay performance in ESKD patients on haemodialysis. Methods: Cross-sectional multi-centre study comparing the performance of the two assays on 112 haemodialysis patients without known paraproteinaemia. We quantified FLC pre- and post-dialysis using both the N Latex and the Freelite assays. Results: FLC levels were elevated by both assays. Lambda FLC levels were considerably higher by the N Latex assay. Using the proposed renal reference range for Freelite (0.37–3.1) all but one patient had normal kappa:lambda FLC ratios. In contrast, there were no abnormal FLC ratios pre-dialysis using the N Latex assay. This was due to lambda FLC reading significantly higher by the N Latex assay. Kappa and lambda FLC levels decreased with dialysis but remained elevated above the normal range. The excess of lambda FLC by N Latex persisted post-dialysis but was somewhat attenuated. Dialysis adequacy and dialysis modality predicted clearance of kappa and lambda FLC by both assays. Conclusions: The N Latex assay reported significantly higher pre-dialysis lambda FLC concentrations compared with the Freelite assays. Clinicians should be aware of the need for a separate renal reference range for interpreting FLC ratio using the Freelite assay but not for the N Latex assay in ESKD patients.
Investigations on error minimizing training criteria for discriminative training in automatic speech recognition

Discriminative training criteria have been shown to consistently outperform maximum likelihood trained speech recognition systems. In this paper we employ the Minimum Classification Error (MCE) criterion to optimize the parameters of the acoustic model of a large scale speech recognition system. The statistics for both the correct and the competing model are solely collected on word lattices without the use of N -best lists. Thus, particularly for long utterances, the number of sentence alternatives taken into account is significantly larger compared to N -best lists. The MCE criterion is embedded in an extended unifying approach for a class of discriminative training criteria which allows for direct comparison of the performance gain obtained with the improvements of other commonly used criteria such as Maximum Mutual Information (MMI) and Minimum Word Error (MWE). Experiments conducted on large vocabulary tasks show a consistent performance gain for MCE over MMI. Moreover, the improvements obtained with MCE turn out to be in the same order of magnitude as the performance gains obtained with the MWE criterion.
Locomotor Performance in Highly-Trained Young Soccer Players: Does Body Size Always Matter?

Abstract To examine the effects of body size on locomotor performance, 807 15-year-old French and 64 Qatari soccer players participated in the present study. They performed a 40-m sprint and an incremental running test to assess maximal sprinting (MSS) and aerobic speeds, respectively. French players were advanced in maturity, taller, heavier, faster and fitter than their Qatari counterparts (e.g., Cohen’s d=+1.3 and + 0.5 for body mass and MSS). However, when adjusted for body mass (BM), Qatari players had possibly greater MSS than French players (d=+0.2). A relative age effect was observed within both countries, with the players born in the first quarter of the year being taller, heavier and faster that those born during the fourth quarter (e.g., d=+0.2 for MSS in French players). When directly adjusted for BM, these MSS differences remained (d=+0.2). Finally, in both countries, players selected in National teams were taller, heavier, faster and fitter than their non-selected counterparts (e.g., d=+0.6 for MSS in French players), even after adjustments for body size (d=+0.5). Differences in locomotor performances between players with different phenotypes are likely mediated by differences in body size. However, when considering more homogeneous player groups, body dimensions are unlikely to substantially explain the superior locomotor performances of older and/or international players.
Continuous-Wave Operation of Semiconductor Optical Amplifier-Based Multiwavelength Tunable Fiber Lasers With 25-GHz Spacing

We demonstrate wide bandwidth operation in a semiconductor optical amplifier (SOA)-based fiber laser with a wavelength spacing of 25 GHz. A broadband multiwavelength filter based on superimposed and chirped fiber Bragg gratings is used for wavelength selection. Three different cavity configurations are presented and compared: 1) a single-SOA standing-wave cavity; 2) a single-SOA ring cavity; and 3) a double-SOA ring cavity. Up to 41 wavelengths are obtained with a signal-to-noise ratio of 35 dB and a wavelength tunability of 10 nm.
Relationship-aware code search for JavaScript frameworks

JavaScript frameworks, such as jQuery, are widely used for developing web applications. To facilitate using these JavaScript frameworks to implement a feature (e.g., functionality), a large number of programmers often search for code snippets that implement the same or similar feature. However, existing code search approaches tend to be ineffective, without taking into account the fact that JavaScript code snippets often implement a feature based on various relationships (e.g., sequencing, condition, and callback relationships) among the invoked framework API methods. To address this issue, we present a novel Relationship-Aware Code Search (RACS) approach for finding code snippets that use JavaScript frameworks to implement a specific feature. In advance, RACS collects a large number of code snippets that use some JavaScript frameworks, mines API usage patterns from the collected code snippets, and represents the mined patterns with method call relationship (MCR) graphs, which capture framework API methods’ signatures and their relationships. Given a natural language (NL) search query issued by a programmer, RACS conducts NL processing to automatically extract an action relationship (AR) graph, which consists of actions and their relationships inferred from the query. In this way, RACS reduces code search to the problem of graph search: finding similar MCR graphs for a given AR graph. We conduct evaluations against representative real-world jQuery questions posted on Stack Overflow, based on 308,294 code snippets collected from over 81,540 files on the Internet. The evaluation results show the effectiveness of RACS: the top 1 snippet produced by RACS matches the target code snippet for 46% questions, compared to only 4% achieved by a relationship-oblivious approach.
VISUALIZATION ON A BULLETIN BOARD SYSTEM

It is important for a collaborative community to decide its next action. The leader of a collaborative community must choose an action that increases rewards and reduces risks. When a leader cannot make this decision, action will be determined through community member discussion. However, this decision cannot be made in blind discussions, so systematic discussion is necessary to choose effective action in a limited time. In this paper, we propose a bulletin board system framework in which effective discussion is established through visualized discussion logs.
Object permanence in 3½- and 4½-month-old infants.

These experiments tested object permanence in 3 1/2and 4 l/2-month-old infants. The method used in the experiments was similar to that used by Baillargeon, Spelke, and Wasserman (1985). The infants were habituated to a solid screen that rotated back and forth through a 180* arc, in the manner of a drawbridge. Following habituation, a box was placed behind the screen and the infants were shown two test events. In one (possible event), the screen rotated until it reached the occluded box; in the other (impossible event), the screen rotated through a full 180" arc, as though the box were no longer behind it. The 4 l/2-month-olds, and the 3 V2-month-olds who were fast habituators, looked reliably longer at the impossible than at the possible event, suggesting that they understood that (a) the box continued to exist after it was occluded by the screen and (b) the screen could not rotate through the space occupied by the occluded box. Control experiments conducted without the box supported this interpretation. The results of these experiments call into serious question Piaget's (1954) claims about the age at which object permanence emerges and about the processes responsible for its emergence.
Using Testlet Response Theory to Examine Local Dependence in C-Tests

C-tests are gap-filling tests widely used to assess general language proficiency for purposes of placement, screening, or provision of feedback to language learners. C-tests consist of several short texts in which parts of words are missing. We addressed the issue of local dependence in C-tests using an explicit modeling approach based on testlet response theory. Data were provided by a total sample of 4,708 participants working on eight C-test texts with 20 gaps each. The resulting parameter estimates were compared to those obtained from (a) a polytomous item response theory (IRT) model and (b) a standard IRT model that ignored the dependence structure. Testlet effects proved to be very small and correspondence between parameters obtained from the different modeling approaches was high. When local dependence was ignored reliability of the C-test was slightly overestimated. Implications for the analysis of testlets in general, and C-tests in particular are discussed.
Person re-Identification over distributed spaces and time

Replicating the human visual system and cognitive abilities that the brain uses to process the information it receives is an area of substantial scientific interest. With the prevalence of video surveillance cameras a portion of this scientific drive has been into providing useful automated counterparts to human operators. A prominent task in visual surveillance is that of matching people between disjoint camera views, or re-identification. This allows operators to locate people of interest, to track people across cameras and can be used as a precursory step to multi-camera activity analysis. However, due to the contrasting conditions between camera views and their effects on the appearance of people re-identification is a non-trivial task. This thesis proposes solutions for reducing the visual ambiguity in observations of people between camera views This thesis first looks at a method for mitigating the effects on the appearance of people under differing lighting conditions between camera views. This thesis builds on work modelling inter-camera illumination based on known pairs of images. A Cumulative Brightness Transfer Function (CBTF) is proposed to estimate the mapping of colour brightness values based on limited training samples. Unlike previous methods that use a mean-based representation for a set of training samples, the cumulative nature of the CBTF retains colour information from underrepresented samples in the training set. Additionally, the bi-directionality of the mapping function is explored to try and maximise re-identification accuracy by ensuring samples are accurately mapped between cameras. Secondly, an extension is proposed to the CBTF framework that addresses the issue of changing lighting conditions within a single camera. As the CBTF requires manually labelled training samples it is limited to static lighting conditions and is less effective if the lighting changes. This Adaptive CBTF (A-CBTF) differs from previous approaches that either do not consider lighting change over time, or rely on camera transition time information to update. By utilising contextual information drawn from the background in each camera view, an estimation of the lighting change within a single camera can be made. This background lighting model allows the mapping of colour information back to the original training conditions and thus remove the need for
Cortical Thickness in Fusiform Face Area Predicts Face and Object Recognition Performance

The fusiform face area (FFA) is defined by its selectivity for faces. Several studies have shown that the response of FFA to nonface objects can predict behavioral performance for these objects. However, one possible account is that experts pay more attention to objects in their domain of expertise, driving signals up. Here, we show an effect of expertise with nonface objects in FFA that cannot be explained by differential attention to objects of expertise. We explore the relationship between cortical thickness of FFA and face and object recognition using the Cambridge Face Memory Test and Vanderbilt Expertise Test, respectively. We measured cortical thickness in functionally defined regions in a group of men who evidenced functional expertise effects for cars in FFA. Performance with faces and objects together accounted for approximately 40% of the variance in cortical thickness of several FFA patches. Whereas participants with a thicker FFA cortex performed better with vehicles, those with a thinner FFA cortex performed better with faces and living objects. The results point to a domain-general role of FFA in object perception and reveal an interesting double dissociation that does not contrast faces and objects but rather living and nonliving objects.