Miracle-dz/UniFAR-FTUs huggingface dataset:
A Network Analysis of Depressive Symptoms in Individuals Seeking Treatment for Chronic Pain

Objectives: Major depression in the context of chronic pain has been conceptualized implicitly as a latent variable, in which symptoms are viewed as manifestations of an underlying disorder. A network approach provides an alternative model and posits that symptoms are causally connected, rather than merely correlated, and that disorders exist as systems, rather than as entities. The present study applied a network analysis to self-reported symptoms of major depression in patients with chronic pain. The goals of the study were to describe the network of depressive symptoms in individuals with chronic pain and to illustrate the potential of network analysis for generating new research questions and treatment strategies. Materials and Methods: Patients (N=216) admitted to an interdisciplinary chronic pain rehabilitation program provided symptom self-reports using the Patient Health Questionnaire-9. Well-established network analyses methods were used to illustrate the network of depressive symptoms and determine the centrality of each symptom (ie, the degree of connection with other symptoms in the network). Results: The most central symptoms were difficulty concentrating, loss of interest or pleasure, depressed mood, and fatigue, although the relative position of each symptom varied slightly, depending on the centrality measure considered. Discussion: Consistent with past research with patients undergoing treatment for major depression, the current findings are supportive of a model in which depressive symptoms are causally connected within a network rather than being manifestations of a common underlying disorder. The research and clinical implications of the findings, such as developing treatments targeting the most central symptoms, are discussed.
Applying Sustainable Value Methodology for Hungarian Agriculture

The Sustainable Value method is a promising approach for accessing sustainability performance of a given activity using the concept of opportunity cost and the performance of a given benchmark. In this study the performance of the Hungarian agriculture is studied. Using FADN data for the period of 2002-2006, the possible effect of the EU accession on agricultural production is examined. Structural, economic and human factors are considered in order to gain better understanding of the differences.
Wholly‐owned vs. collaborative ventures for diversifying financial services

Recent empirical work has supported the Penrose-Teece view that firms diversify to exploit fully specific assets or capabilities. Where transactions costs permit, these economies of scope may be realized via input supply contracts among producers. However, asset specificities frequently create transactions costs which discourage market contracting and leave firms with a choice between collaborative ventures and wholly-owned new entry. This research uses the natural experiment of financial services deregulation to explore the collaborative-own entry choice for 292 new entries in 13 financial product markets. The results generally support our maintained hypotheses that specificity encourages full ownership while collaboration is used to ease a resource constraint.
Classification model for test case prioritization techniques

Regression Testing is mainly done in software maintenance aiming to assure that the changes made in the software have correctly been implemented and also to achieve the confidence that the modifications have not affected the other parts of the software. It is very costly and expensive technique. There are number of techniques present in literature that focus on achieving various testing objectives early in the process and hence reduces its cost. Despite of that, testers usually prefer only few already known techniques for test case prioritization. The main reason behind is the absence of guidelines for the selection of TCP techniques. Hence, this piece of research introduces a novel approach for classification of TCP techniques using fuzzy logic to support the efficient selection of test case prioritization techniques. This work is an extension of already proposed selection schema for test case prioritization techniques. To perform the validation of proposed approach results are compared with other classification techniques using Weka tool. The analysis clearly shows the effectiveness of proposed approach as compared to others in terms of its accuracy.
Robot education peers in a situated primary school study: Personalisation promotes child learning

The benefit of social robots to support child learning in an educational context over an extended period of time is evaluated. Specifically, the effect of personalisation and adaptation of robot social behaviour is assessed. Two autonomous robots were embedded within two matched classrooms of a primary school for a continuous two week period without experimenter supervision to act as learning companions for the children for familiar and novel subjects. Results suggest that while children in both personalised and non-personalised conditions learned, there was increased child learning of a novel subject exhibited when interacting with a robot that personalised its behaviours, with indications that this benefit extended to other class-based performance. Additional evidence was obtained suggesting that there is increased acceptance of the personalised robot peer over a non-personalised version. These results provide the first evidence in support of peer-robot behavioural personalisation having a positive influence on learning when embedded in a learning environment for an extended period of time.
Innovations from the early user phase on the Jetstream Research Cloud

—We describe the Jetstream cyberinfrastructure for research, a purpose-built system with the goal of supporting “long-tail” research by providing a ﬂexible infrastructure that can provide a set cloud services tuned for research applications, whether they be traditional HPC applications, science gateways, or desktop applications. Jetstream offers a library of virtual machines and allows the user to create their own virtual machines in order to provide an open cloud for science that allows both on-demand and persistent instances. The system is currently in early-user mode and a number of users at partner institutions are already creating and using images in the system. This paper details some of the early work being done with the system to create high performance clusters in an on-demand fashion to support scientiﬁc work directly as well as serve as capability backend to scientiﬁc gateways such as CyVerse and Galaxy.
Prognostic factors in cats with feline panleukopenia.

BACKGROUND Feline panleukopenia is a highly contagious and often lethal disease. OBJECTIVE The purpose of the study was to identify prognostic factors for survival of cats with panleukopenia. ANIMALS Between 1990 and 2007, 244 cats were diagnosed with panleukopenia in the Clinic of Small Animal Medicine, LMU University of Munich, Germany. Diagnosis was established by electron microscopy, polymerase chain reaction of feces or blood, antigen ELISA of feces, pathognomonic histopathological lesions at necropsy, or some combination of these procedures. METHODS Medical records of each cat were evaluated retrospectively. RESULTS Survival rate was 51.1%. No significant correlation was found between outcome and living conditions, age, vaccination status (unvaccinated versus one or more vaccines administered), or severity of clinical signs. However, of the vaccinated cats, none had received a vaccine later than 12 weeks of age as a kitten. Nonsurvivors had significantly lower leukocyte and thrombocyte counts at presentation compared with survivors. The relative risk of death for patients with <1,000/μL leukocytes was 1.77 times as high as in patients with a leukocyte count of 1,000-2,500/μL (P=.038), and 1.85 times as high as in patients with >2,500/μL leukocytes (P=.001). The likelihood of a fatal outcome was higher when serum albumin concentration was <30 g/L or serum potassium concentration <4 mmol/L. CONCLUSIONS AND CLINICAL IMPORTANCE Vaccination strategies that do not include vaccination of kittens beyond 12 weeks of age may not be adequate to prevent panleukopenia. Leukopenia, thrombocytopenia, hypoalbuminemia, and hypokalemia are negative prognostic factors in cats with panleukopenia.
TLR4 Signaling Augments Monocyte Chemotaxis by Regulating G Protein–Coupled Receptor Kinase 2 Translocation

Monocytes are critical effector cells of the innate immune system that protect the host by migrating to inflammatory sites, differentiating to macrophages and dendritic cells, eliciting immune responses, and killing pathogenic microbes. MCP-1, also known as CCL2, plays an important role in monocyte activation and migration. The chemotactic function of MCP-1 is mediated by binding to the CCR2 receptor, a member of the G protein–coupled receptor (GPCR) family. Desensitization of GPCR chemokine receptors is an important regulator of the intensity and duration of chemokine stimulation. GPCR kinases (GRKs) induce GPCR phosphorylation, and this leads to GPCR desensitization. Regulation of subcellular localization of GRKs is considered an important early regulatory mechanism of GRK function and subsequent GPCR desensitization. Chemokines and LPS are both present during Gram-negative bacterial infection, and LPS often synergistically exaggerates leukocyte migration in response to chemokines. In this study, we investigated the role and mechanism of LPS–TLR4 signaling on the regulation of monocyte chemotaxis. We demonstrate that LPS augments MCP-1–induced monocyte migration. We also show that LPS, through p38 MAPK signaling, induces phosphorylation of GRK2 at serine 670, which, in turn, suppresses GRK2 translocation to the membrane, thereby preventing GRK2-initiated internalization and desensitization of CCR2 in response to MCP-1. This results in enhanced monocyte migration. These findings reveal a novel function for TLR4 signaling in promoting innate immune cell migration.
Multi-sensor Tactile Perception For Object Manipulation/identification

The varied range of components that must be detected makes tactile Sensors the most sophisticated set of sensing organs in the human body. Unfortunately this complexity also means that there is no effective robotic equivalent to the nerves in skin. This paper reports on the development of a multi-functional tactile sensor capable of collecting data on an broad range of tactile parameters such as contact pressurefforce, texture, hardness, shear, surface profile and slip. This extensive range provides an excellent vehicle for sensor fusion development both at the primary detection level and at the higher perceptual level where data from the sensory sets are fused by an expert identification system. This information has been combined to form an expert identifier for object classification (metal, glass, stone, wood, plastic, paper, and fabric) using only touch.
Low loss Si-SiO2-Si 8nm slot waveguides

Quasi-TM-mode propagation loss of 1.83 dB/cm at lambda = 1.565 mum is achieved in horizontal Si(amorphous)-SiO2-Si(crystalline) slot waveguides with 8.3 nm slots fabricated on silicon-on-insulator. Waveguide loss is measured using a ring resonator with Q ~ 3x105.
ℌ2 pseudo-optimality in model order reduction by Krylov subspace methods

New sufficient conditions for ℌ2 pseudo-optimality in Krylov-based model reduction of linear dynamical systems are presented. The conditions are easy to evaluate and permit first applications: a new algorithm to generate ℌ2 pseudo-optimal reduced models with respect to the projecting subspace and a procedure to generate superior local optima in iterative methods. Numerical examples illustrate the contributions.
Exposure-Response Analyses for Tafenoquine after Administration to Patients with Plasmodium vivax Malaria

ABSTRACT Tafenoquine (TQ), a new 8-aminoquinoline with activity against all stages of the Plasmodium vivax life cycle, is being developed for the radical cure of acute P. vivax malaria in combination with chloroquine. The efficacy and exposure data from a pivotal phase 2b dose-ranging study were used to conduct exposure-response analyses for TQ after administration to subjects with P. vivax malaria. TQ exposure (i.e., area under the concentration-time curve [AUC]) and region (Thailand compared to Peru and Brazil) were found to be statistically significant predictors of clinical response based on multivariate logistic regression analyses. After accounting for region/country, the odds of being relapse free at 6 months increased by approximately 51% (95% confidence intervals [CI], 25%, 82%) for each 25-U increase in AUC above the median value of 54.5 μg · h/ml. TQ exposure was also a significant predictor of the time to relapse of the infection. The final parametric, time-to-event model for the time to relapse, included a Weibull distribution hazard function, AUC, and country as covariates. Based on the model, the risk of relapse decreased by 30% (95% CI, 17% to 42%) for every 25-U increase in AUC. Monte Carlo simulations indicated that the 300-mg dose of TQ would provide an AUC greater than the clinically relevant breakpoint obtained in a classification and regression tree (CART) analysis (56.4 μg · h/ml) in more than 90% of subjects and consequently result in a high probability of being relapse free at 6 months. This model-based approach was critical in selecting an appropriate phase 3 dose. (This study has been registered at ClinicalTrials.gov under registration no. NCT01376167.)
Brands: The asset test

This paper has the implicit theme that there are changes afoot in both the marketing and accounting professions. Explicitly, how changes in the accounting area may affect marketing people is explored. The particular focus is brands, especially their capitalization in the balance sheet of some companies. The controversy around this practice is discussed, and suggestions for the possible impact on marketing outlined. Many companies are already reviewing the way that they manage their brands, and some are. restructuring accordingly. This may be the beginning of many such changes. The brand valuation and capitalization debate is reviewed from the late 1980s to date. The Accounting Standards Board (ASB) has now released Financial Reporting Standards that relate to the discussion, but do not, as one might hope, conclude it. The standards deal with intangible assets generally, rather than brands specifically. Hence the treatment of brands remains ambiguous and open to interpretation. Financial reporting systems,.
Future Cast System

Most likely, everyone has gone through dreaming of acting a hero in the movie. The system called “Future Case System”(FCS) is a new entertainment system that is easily able to accomplish that dream. FCS has been implemented in MITSUI TOSHIBA pavilion at Expo 2005 Aichi Japan first in the world. This attraction is to allow 240 theater attendances to have a role of the movie they are watching. Comparing FCS with Previous Attraction Systems (PASs), PASs provide the visual information to visitors one-sidedly. On the other hand, since attendances’ faces come out on the screen, they can feel as if they are acting in the movie. This is the main idea of FCS and makes attendances’ feeling of immersion increase.
Insider Sentiment and Market Returns around the World

In this study I exploit recent regulatory initiatives requiring the timely disclosure of corporate insider trades to investigate the predictive content of aggregate equity purchases and sales by senior corporate officers and directors around the world. Consistent with evidence in the U.S., aggregate net purchases by corporate insiders are positively associated with future country-level market returns. More importantly, the predictive content of aggregate insider trades is driven by countries with less transparent information environments and, to a lesser extent, lower investor protection. Collectively, the evidence is consistent with corporate insiders around the world trading upon domestic macroeconomic news, and their aggregate trading behavior having greater predictive content in countries where the quality of capital market institutions is relatively lower.
Targeting mitochondrial transcription in fission yeast with ETB, an inhibitor of HSP60, the chaperone that binds to the mitochondrial transcription factor Mtf1

Mtf1 has been characterized as a mitochondrial transcription factor and is shown to regulate mitochondrial transcription. Mtf1 has an additional function as a transcription factor for the nuclear gene srk1 in fission yeast. Hsp60 has been linked to a variety of important cellular functions such as apoptosis and the immune response. It functions mainly as a molecular chaperone that assists correct protein folding in the mitochondrion. Epolactaene tertiary butyl ester (ETB) is an inhibitor of human Hsp60 that can inhibit Hsp60 chaperone activity. In this study, we report that in fission yeast, Mtf1 binds to Hsp60 in vivo and in vitro, ETB inhibits the binding of Mtf1 and Hsp60, and inhibits mitochondrial transcription but not nuclear transcription of srk1. We propose that Hsp60 may act as a molecular chaperone that folds mitochondrial Mtf1 into a functional form and that ETB inhibits this Hsp60 chaperone activity by disrupting Mtf1 binding to Hsp60 and thus inhibits mitochondrial transcription in fission yeast.
Navigation system of mobile robot in an uncertain environment using type-2 fuzzy modelling

A navigation system of a mobile robot in an uncertain environment is one of a popular research area. There are both static and dynamic obstacles in an uncertain environment. If a robot finds a static obstacle, it can select a safe path very easily. However, a dynamic obstacle can move very randomly in the global map. Hence, in this paper, we propose a navigation system in an uncertain environment focusing on dynamic obstacles for a mobile robot. The future position of a dynamic obstacle is modeled using a fuzzy vector. The dangerous region of that obstacle is then computed. Then the free road candidates are computed based on those dangerous regions found. Then the best free road is selected. Finally, the interval type-2 fuzzy logic system is utilized to compute the velocity and angular velocity of a mobile robot. The experiment results show that our navigation system worked in an uncertain environment, i.e., an environment with an obstacle with stable velocity and angular velocity, an environment with an obstacle with random velocity, and an environment with several obstacles with both condition.
Improvement of the governance and management of Icelandic public projects

In the context of the public sector, there will always be more demand for projects than available resources. The portfolio of possible projects is restricted since investment capital is limited. To ensure the optimal use of investment capital, it is essential to select the most promising projects only. In order to support this goal the correct procedures must be in place and applied consistently. The subject of the study presented here is the preparation of feasibility studies for public projects in Iceland. Since the collapse of the country’s financial system in 2008, a reform program has been enacted in several areas of governance resulting in, among other things, the draft of a new constitution. Even so, it seems that reform has not reached as far as capital projects since they continue to be a subject of debate and a challenge for managers. In this study, six projects were screened from the perspective of how the initial feasibility is determined in relation to notional best practice. The findings show that there is a disparity between best practice and current practice in Iceland to an extent that should be of concern to all stakeholders, not least taxpayers. Selection and peer-review under responsibility of the IPMA.
EFFECTS OF TECHNOLOGY READINESS ON TECHNOLOGY ACCEPTANCE IN E-HRM: MEDIATING ROLE OF PERCEIVED USEFULNES

The aim of this paper is to investigate the effects of technology readiness on technology acceptance in the eHRM field. The data for this study were collected from 86 Human Resource (HR) managers representing top 500 largest private sector companies in Turkey. The research model was based on two theories: Parasuraman’s technology readiness and Davis' technology acceptance model. The results of the study showed that optimism and innovativeness of technology readiness positively influenced perceived usefulness and perceived ease of use, but discomfort and insecurity have no positive effects on them
The Effects of N2O Plasma Treatment on the Device Performance of Solution-Processed a-InMgZnO Thin-Film Transistors

In this paper, the effects of N<sub>2</sub>O plasma treatment (PT) at various temperatures on the performances of InMgZnO (IMZO) thin-film transistors (TFTs) were investigated. As a result, the TFTs with N<sub>2</sub>O plasma-treated (10 W) IMZO channel layers at 100° for 10 min showed five times higher linear field-effect mobility compared to the untreated IMZO. The N<sub>2</sub>O PT did not cause any significant changes to the crystal structure, surface roughness of the IMZO thin films. However, an X-ray photoelectron spectroscopy study confirmed that the oxygen-vacancy defect density of the channel layer decreases via the N<sub>2</sub>O PT with temperature increased, and the reduction of oxygen vacancies leads to a decrease of off-current (I<sub>OFF</sub>). It was found out that the refractivity of the channel layer increases with PT temperature increased, and the improvement of the film density makes the on-current (I<sub>ON</sub>) higher, resulting in high mobility and high <inline-formula> <tex-math notation="LaTeX">${I}_{ \mathrm{\scriptscriptstyle ON}}/{I}_{ \mathrm{\scriptscriptstyle OFF}}$ </tex-math></inline-formula> ratio. Our study suggests that moderate N<sub>2</sub>O PT temperature can be adopted to improve the device performances.
"Fair-Share" for Fair Bandwidth Allocation in Cloud Computing

Current mechanisms for controlling network resources cannot prevent users from interfering with each other in a shared cloud environment. Proposals made to rectify this, use mechanisms which require interrupts with high timing precision, and usually unevenly distribute bandwidth to TCP flows. We propose the use of an alternative mechanism to manage network resources and compare the performance of both.
Near-infrared light-triggered thermochemotherapy of cancer using a polymer–gold nanorod conjugate

A biocompatible polymer–gold nanorod (P-AuNR) conjugate was developed as a thermo-chemotherapeutic nano-sized drug carrier for cancer therapy using near-infrared (NIR) light as an external trigger. The amphiphilic polymer, poly(ethylene glycol)-block-poly(caprolactone) (PEG-b-PCL) bearing a disulfide bond, was prepared using a facile synthetic route via copper(I)-free click chemistry and covalently linked to AuNR. The chemical structures and successful conjugation of PEG-b-PCL were analyzed using 1H NMR and FT-IR. Doxorubicin (DOX), a hydrophobic anticancer drug, was effectively loaded into the hydrophobic PCL domain of P-AuNR through a simple dialysis method. P-AuNR showed longitudinal plasmon resonance absorption at the NIR region, thus generating heat under irradiation at 808 nm. Interestingly, exposure of P-AuNRs to NIR induced a structural change in the PCL block from a crystalline to an amorphous state, leading to the temporally controlled release of DOX. No significant release of DOX was observed from P-AuNRs under physiological conditions (pH 7.4), whereas the release rate of DOX was remarkably enhanced in response to NIR irradiation. In vitro cellular experiments to assess cytotoxicity and intracellular drug release behavior of DOX-P-AuNRs demonstrated that the release of DOX could be selectively regulated by NIR irradiation. Overall, DOX-P-AuNRs might have the potential to overcome the indiscriminate toxicity of free DOX.