Miracle-dz/UniFAR-FTUs huggingface dataset:
SELECTIVE RELEASE OF CONTENT FROM MICROSOMAL VESICLES WITHOUT MEMBRANE DISASSEMBLY

Rough and smooth microsomes were shown to have similar sets of polypeptide chains except for the proteins of ribosomes bound to the rough endoplasmic reticulum (ER). More than 50 species of polypeptides were detected by acrylamide gel electrophoresis, ranging in molecular weight from 10,000 to approximately 200,000 daltons. The content of rough and smooth microsomes was separated from the membrane vesicles using sublytic concentrations of detergents and differential centrifugation. A specific subset of proteins which consisted of approximately 25 polypeptides was characteristic of the microsomal content. Some of these proteins showed high rates of in vivo incorporation of radioactive leucine or glucosamine, but several others incorporated only low levels of radioactivity within short labeling intervals and appeared to be long-term residents of the lumen of the ER. Seven polypeptides in the content subfractions, including serum albumin, contained almost 50% of the leucine radioactivity incorporated during 5 min and cross-reacted with antiserum against rat serum. Almost all microsomal glycoproteins were at least partly released with the microsomal content. Smooth microsomes contained higher levels of albumin than rough microsomes, but after short times of labeling with [3H]leucine the specific activity of albumin in the latter was higher, supporting the notion that newly synthesized serum proteins are transferred from rough to smooth portions of the ER. On the other hand, after labeling for 30 min with [3H]glucosamine, smooth microsomes contained higher levels of radioactivity than rough microsomes. This would be expected if glycosidation of newly synthesized polypeptides proceeds during their transit through ER cisternae. The labeling pattern of membrane proteins in microsomes obtained from animals which received three daily injections of [3H]leucine, the last administered 1 day before sacrifice, followed the intensity of bands stained with Coomassie blue, with a main radioactive peak corresponding to cytochrome P 450. After the long-term labeling procedure most content proteins had low levels of radioactivity; this was especially true of serum proteins which were highly labeled after 30 min.
The familial history of hypertension influences the blood pressure response to the resistance exercise in normotensive men

Introduction: It is well known that familial or genetic heritage is closely associated to hypertension. Thus the present study aimed to investigate BP response to resistance exercise from young normotensive subjects with (WFHH) and without (WTFHH) familial history of hypertension (FHH). Material and Methods: Forty-nine healthy male, engaged in military service, were clinically examined. After anamneses volunteers were divided into two groups based on the FHH (mother and/or father). The groups were named: WFHH (n=22) and WTFHH (n=27). Volunteers performed three sets of 10 repetitions of unilateral knee extension at 50%, 75% and 100% of 10 repetition maximum (RM), with two-minute rest intervals between sets. Blood pressure measures were obtained at rest (PRE) and immediately after (POS) each exercise set. Result and Discussion: The results reveal that WFHH group exhibited greater SBP and PP response to resistance exercise at 50% of 10RM. These findings may indicate the presence of functional, and/or subclinical structural changes in young subjects with FHH, which are not clear at rest condition, but revealed during light resistance exercise.
MATRIX: Maintenance-Oriented Testing Requirements Identifier and Examiner

This paper presents a new test-suite augmentation technique for use in regression testing of software. Our technique combines dependence analysis and symbolic evaluation and uses information about the changes between two versions of a program to (1) identify parts of the program affected by the changes, (2) compute the conditions under which the effects of the changes are propagated to such parts, and (3) create a set of testing requirements based on the computed information. Testers can use these requirements to assess the effectiveness of the regression testing performed so far and to guide the selection of new test cases. The paper also presents MATRIX, a tool that partially implements our technique, and its integration into a regression-testing environment. Finally, the paper presents a preliminary empirical study performed on two small programs. The study provides initial evidence of both the effectiveness of our technique and the shortcomings of previous techniques in assessing the adequacy of a test suite with respect to exercising the effect of program changes
A systematic review of research on educational leadership and management in South Africa: mapping knowledge production in a developing society

Abstract For much of the past 60 years, the ‘visible’ knowledge base consisted almost entirely of studies that described EDLM policies and practices from a relatively small number of Anglo-American societies. Over the past five years, reviews of research have revealed abundant evidence of rapidly increasing publication output from developing societies in Asia, Africa and Latin America. A recent review of Africa’s EDLM literature identified South Africa as a ‘positive outlier’ in knowledge production. The current review examined South Africa’s published EDLM scholarship in terms of its volume, growth over time, distribution across scholarly journals and authors, citation impact, as well as types of studies, research methods, conceptual models and topics. The database of sources for the review consisted of 292 EDLM articles published in English language journals up to the end of 2016. The review employed quantitative ‘topographical analysis’ aimed at describing key features of the African knowledge base in EDLM. Patterns in the topography of the South African literature identified in this review were also benchmarked against findings reported in reviews of research conducted in other societies and regions of the world.
An efficient and scalable implementation of global EDF in Linux

The increasing popularity of multi-core architectures is pushing researchers and developers to consider multi-cores for executing soft and hard real-time applications. Real-Time schedulers for multi processor systems can be roughly categorized into partitioned and global schedulers. The first ones are more adequate for hard real-time embedded systems, in which applications are statically loaded at start-up and rarely change at run-time. Thanks to automatic load balancing, global schedulers may be useful in open systems, where applications can join and leave the system at any time, and for applications with highly varying workloads. Linux supports global and partitioned scheduling through its real-time scheduling class, which provides SCHED FIFO and SCHED RR fixed priority policies. Recently, the SCHED DEADLINE policy was proposed that provides Earliest Deadline First scheduling with budget control. In this paper we propose a new implementation for global EDF scheduling which uses a heap global data structure to speed-up scheduling decisions. We also compare the execution time of the main scheduling functions in the kernel for four different implementations of global scheduling, showing that our implementation is as scalable and efficient as SCHED FIFO. ∗The research leading to these results has received funding from the European Community’s Seventh Framework Programme n.248465 “S(o)OS – Service-oriented Operating Systems. ”
A discrete-time survival study of drug use and property offending : implications for early intervention and treatment

The nexus between drug use and criminal offending is of great interest to policy makers and researchers alike. The possibility that both illegal activities are interrelated provides promise that targeted interventions, such as drug diversion programs and drug courts, may have a tangible influence in reducing the social and economic costs of crime to the community. Although most in the academic and policy arenas agree that drugs and crime are interconnected, the nature of the relationship remains highly contested. This report contributes to this debate through an examination of drug use initiation and criminal escalation where it seeks to identify whether: drug use initiation increases the likelihood of offence escalation, and whether particular drugs play a more or less important role in increasing offending; delayed onset of drug use increases or decreases the risk of offence escalation; and, self-reported motives for the engagement in offending help to predict onset and escalation risk. This study uses data from the Australian Institute of Criminology's Drug Use Careers of Offenders Study (DUCO), an interviewer-administered self-reported survey of offending and drug use, conducted in 2001 among adult male prisoners in Queensland, Western Australia, Tasmania and the Northern Territory to examine the temporal pattern of drug use and offending. Using a survival analysis technique, this study examines the risk profile of 1,500 property offenders and their likelihood of escalating to regular offending. Drug use, including cannabis and other illicit drugs, are modelled as temporal predictors as a means of estimating their effect on increasing or decreasing escalation risk across the criminal career. The results of this study provide some important findings for the development of policies aimed at preventing crime.
Efficient linear text segmentation based on information retrieval techniques

The task of linear text segmentation is to split a large text document into shorter fragments, usually blocks of consecutive sentences. The algorithms that demonstrated the best performance for this task come at the price of high computational complexity. In our work we present an algorithm that has a computational complexity of O(n) with n being the number of sentences in a document. The performance of our approach is evaluated against algorithms of higher complexity using standard benchmark data sets and we demonstrate that our approach provides comparable accuracy.
Open loop pole location bounds for partial positive feedback gain enhancement operational amplifiers

For conventional op amps design open loop poles are usually in the left-half plane. For amplifiers with negative impedance gain enhancement, the open loop pole is adjustable and it can be in the left-half plane or in the right-half plane. In this paper, we justify that it does not require a left-half plane open loop pole for designing a stable close loop amplifier. As a matter of fact, the amplifier exhibits both faster and more accurate settling when the open-loop pole is modestly in the right-half plane. New open loop pole bounds are derived for amplifiers with adjustable open loop pole to guarantee stability and to enhance settling time performance.
Fast Learning from Non-i.i.d. Observations

We prove an oracle inequality for generic regularized empirical risk minimization algorithms learning from α-mixing processes. To illustrate this oracle inequality, we use it to derive learning rates for some learning methods including least squares SVMs. Since the proof of the oracle inequality uses recent localization ideas developed for independent and identically distributed (i.i.d.) processes, it turns out that these learning rates are close to the optimal rates known in the i.i. d. case.
Analytical thruchip inductive coupling channel design optimization

ThruChip interface (TCI) is an emerging 3-D integrated circuit stacking technology. TCI utilizes on-chip inductor to build vertical communication channel in near field distance and has been proved to stand comparison with through-siliconvia (TSV) in data rate, power, and reliability. Moreover, it is also cost-effective in manufacturing due to its wireless nature. In this paper, an analytical method is proposed to find near-optimal TCI inductive coupling channel solution. The experiment results show an average 16.8% transmitting current reduction and shrink design time from days to a few minutes.
Central suboptimal mean-square H∞ controller design for linear stochastic systems

This paper designs the central finite-dimensional H∞ controller for linear stochastic time-varying systems with integral-quadratically bounded deterministic disturbances, that is suboptimal for a given threshold γ with respect to a modified Bolza-Meyer quadratic criterion including the attenuation control term with the opposite sign. In contrast to the previously obtained results, the paper reduces the original H∞ controller problem to the corresponding optimal H2 controller problem, using the technique proposed in [1]. Numerical simulations are conducted to verify performance of the designed controller for a linear stochastic system against the central suboptimal H∞ controller available for the corresponding deterministic system.
DIVERSITY ANTENNA LOADED WITH REACTANCE CONTROL CIRCUITS CONFIGURED WITH VARIABLE CAPACITORS FOR EFFECTIVE COMBINING

Diversity antenna loaded with the reactance control circuits configured with variable capacitors was proposed. Advantages of this proposed configuration are that signals are detected only by one receiver and that the hardware architecture is simple. However, effective combining has not been achieved due to a mismatch between the combiner and the receiver. In order to improve this problem, we considered the resistance of the output load. Finally, we show that the performance of the proposed system is close to selection combining.
Prosody-based sentence boundary detection in Chinese broadcast news

In this paper, we explore the use of prosodic features in sentence boundary detection in Chinese broadcast news. The prosodic features include speaker turn, music, pause duration, pitch, energy and speaking rate. Specifically, considering the Chinese tonal effects in pitch trajectory, we propose to use tone-normalized pitch features. Experiments using decision trees demonstrate that the tone-normalized pitch features show superior performance in sentence boundary detection in Chinese broadcast news. Furthermore, feature combination is able to achieve apparent performance improvement by intuitive feature interactive rules formed in the decision tree. Pause duration and a tone-normalized pitch feature contribute the most part of the feature usage in the best-performing decision tree.
Formulation Over Diverse Information Sources in TAMBIS

Biologists increasingly need to ask complex questions over th large number of data and analysis tools that are available on the Internet. To do this, the individua l resources need to be made to work together. The knowledge needed to accomplish this, for example about the l ocations of the sources and their capabilities, places barriers between biologists and the questions they w ould like to ask. The TAMBIS project (Transparent Access to Multiple Bioinformatics Information Sources) ha s sought to remove some of these barriers, thereby making the process of asking questions against multiple sou rces more straightforward. Central to the TAMBIS system is an ontology of bioinformatics and biological term s. Users express retrieval requests in terms of the concepts and relationships described in the ontology, rath e than by making direct reference to individual sources. This allows TAMBIS to be used to formulate rich, dec larative queries over multiple sources. The ontology is constructed in a manner that ensures only biolog ically meaningful queries can be posed. User’s queries are constructed using an interactive ontology brow sing and query construction tool, and are rewritten by a query planner for evaluation using a wrapper layer. This paper provides an overview of the TAMBIS approach to source integration, focusing on the way the onto l gy is used to support query formulation and refinement.
The Advantages of Bilingualism Debate

Bilingualism was once thought to result in cognitive disadvantages, but research in recent decades has demonstrated that experience with two (or more) languages confers a bilingual advantage in executive functions and may delay the incidence of Alzheimer's disease. However, conflicting evidence has emerged leading to questions concerning the robustness of the bilingual advantage for both executive functions and dementia incidence. Some investigators have failed to find evidence of a bilingual advantage; others have suggested that bilingual advantages may be entirely spurious, while proponents of the advantage case have continued to defend it. A heated debate has ensued, and the field has now reached an impasse. This review critically examines evidence for and against the bilingual advantage in executive functions, cognitive aging, and brain plasticity, before outlining how future research could shed light on this debate and advance knowledge of how experience with multiple languages affects cognition and the brain.
Handover supporting MPLS — COS based tunnel selection forwarding in HMIPV6 networks

Proposed here is a handover scheme based on MPLS-COS forwarding and MPLS-TE in Hierarchical Mobile IPv6 networks designed to meet seamless handover requirements. This proposal takes advantage of hierarchical mobile ipv6 that uses hierarchical network structure to localize registration in one domain [1]. It uses Multiprotocol Label Switching (MPLS) class of service (COS) under IP Layer to provide fast packet forwarding by means of preferential treatment of packets by examining traffic class bits (DSCP) of IPv6 header. Class Based Tunnel Selection Forwarding (CBTF) has the many benefits like segregates tunnel traffic, Controls tunnel bandwidth, Customizes CoS policies, Prioritizes traffic before it enters a tunnel. By using this mechanism, we can ensure that better resource utilization and throughput can be achieved during handoff in HMIPv6 networks.
Prefrontal cortical deficits and impaired cognition-emotion interactions in schizophrenia.

OBJECTIVE Despite schizophrenia patients' reports of diminished experience of emotion in interviews and self-report measures, their emotional experience in the presence of emotional stimuli and in daily life ("in the moment") appears largely intact. To examine emotion-cognition interactions, the authors tested the hypothesis that schizophrenia patients have unimpaired in-the-moment emotional reactivity but have a deficit in prefrontal cortical mechanisms needed to maintain and report on experience following exposure to emotional stimuli. METHOD Using a slow event-related functional MRI paradigm, the authors examined the brain activity of 23 schizophrenia patients and 24 healthy comparison subjects during trials in which they viewed an affective picture and, after a delay, reported their emotional experience while viewing it. RESULTS The patients' self-reports of emotional experience differed from those of the healthy subjects when they rated their experience on dimensions inconsistent with the stimulus valence but not when the dimension was consistent with it. In the presence of emotional stimuli, brain activity in the patients was similar to that of the comparison subjects. During the delay, however, patients showed decreased activation in a network of brain structures, including the dorsolateral prefrontal cortex and other prefrontal, limbic, and paralimbic areas. In patients, the delay-related response of the dorsolateral prefrontal cortex to pleasant stimuli correlated negatively with an anhedonia measure. CONCLUSIONS These results suggest that schizophrenia is characterized by a failure of prefrontal circuitry supporting the link between emotion and goal-directed behavior and that the failure of this mechanism may contribute to deficits in processes related to emotion-cognition interaction.
Creation of a type IIS restriction endonuclease with a long recognition sequence

Type IIS restriction endonucleases cleave DNA outside their recognition sequences, and are therefore particularly useful in the assembly of DNA from smaller fragments. A limitation of type IIS restriction endonucleases in assembly of long DNA sequences is the relative abundance of their target sites. To facilitate ligation-based assembly of extremely long pieces of DNA, we have engineered a new type IIS restriction endonuclease that combines the specificity of the homing endonuclease I-SceI with the type IIS cleavage pattern of FokI. We linked a non-cleaving mutant of I-SceI, which conveys to the chimeric enzyme its specificity for an 18-bp DNA sequence, to the catalytic domain of FokI, which cuts DNA at a defined site outside the target site. Whereas previously described chimeric endonucleases do not produce type IIS-like precise DNA overhangs suitable for ligation, our chimeric endonuclease cleaves double-stranded DNA exactly 2 and 6 nt from the target site to generate homogeneous, 5′, four-base overhangs, which can be ligated with 90% fidelity. We anticipate that these enzymes will be particularly useful in manipulation of DNA fragments larger than a thousand bases, which are very likely to contain target sites for all natural type IIS restriction endonucleases.
The Comprehension Modes of Visual Elements: How People Know About the Contents by Product Packaging

When shoppers enter a retail store, how do they comprehend the products in front of them? What visual elements can communicate messages in an effective way that help people comprehend product contents? Design and marketing personnel should pay attention to these issues. This study aims to investigate how people perceive and comprehend a product. It is conducted in three phases: Phase One involves collecting food package samples with “Stratified Sampling”; Phase Two consists of conducting focus group interviews to seek the participants’ opinions. Phase Three includes a summary and analysis of the interview result. There are seven modes of comprehension obtained from the opinions of focus group members. The research results summarized below can be used as reference for design and marketing personnel in developing new product packages in the future: (a) Focus group members mostly comprehend the messages of packaging via more than two visual elements. (b) “Typography + illustration” is the best mode for group members to comprehend products. (c) Design elements such as brand name, product name, product image, package shape, and color association all contributed to the comprehension of products; while attached product information design, structure design, and volume design did not make such contribution.
Accelerating ATM: on-line compression of ATM streams

Since ATM switches intended to be simple and inexpensive, a significant part of the network cost is in the cost of the links. A way of increasing the traffic we can send over these expensive links is to transmit compressed ATM cells. This idea, although it seems very simple, is a new one for ATM and in this paper we show that it can significantly increase the bandwidth of a typical ATM network. We also show that the buffer size needed for accommodating the peaks introduced by the compression is not prohibitively large, the delay our compression scheme introduces is very low, and that this scheme can be very effective when used with IP traffic.