Miracle-dz/UniFAR-FTUs huggingface dataset:
phexin 4-mediated promotion of cell migration and anoikis resistance is regulated y serine 897 phosphorylation of EphA 2

EphA2 is activated through phosphorylation on serine 897 (S897) by Akt to promote cancer cell motility and invasion, independently of stimulation by ephrin, its ligand. Here we show that S897 phosphorylation of EphA2 strengthens the interaction between EphA2 and Ephexin4, a guanine nucleotide exchange factor for the small GTPase RhoG. S897A mutation of EphA2 abolished the EphA2/Ephexin4-mediated RhoG activation, promotion of cell migration, and resistance to anoikis. Our results suggest that S897phosphorylated EphA2 recruits Ephexin4 to promote cell migration and anoikis resistance, providing a molecular link between S897 phosphorylation of EphA2 and tumor progression. C © 2013 The Authors. Published by Elsevier B.V. on behalf of Federation of European Biochemical Societies. Open access under CC BY-NC-ND license.
Operating Region Boundary for Coordinated Two-Point Joint Diversity Transmission Under an Outage Rate Requirement

In this letter, we check the feasibility of coordinated two-point (Co2P) joint diversity transmission (JDT) under an outage rate requirement. We first derive the outage rate expression for a Co2P JDT network in Rayleigh fading channels. We then obtain the relationship for determining the exact operating region boundary. Furthermore, we present an approximate operating region boundary using a simple piecewise linear approximation and another approximate operating region boundary using a more accurate quartic approximation. Finally, we analyze the resulting outage rates. From numerical results, we validate that the outage rate curve, along with the approximate boundary using the quartic approximation, matches well with the required outage rate over the entire signal-to-noise ratio (SNR) regime. In addition, we validate that the approximate boundary can guarantee the required outage rate by introducing small margins of +0.2 dB for both the boundary-forming mean branch SNRs.
Structural and electrical properties of perovskite Ba ( Sm 1 / 2 Nb 1 / 2 ) O 3 – BaTiO 3 ceramic

The structural and electrical properties of (1-x)Ba(Sm1/2Nb1/2)O3–xBaTiO3; (0≤ x≤1) ceramics were prepared by conventional ceramic technique at 1375C/7 h in air atmosphere. The crystal symmetry, space group and unit cell dimensions were derived from the X-ray diffraction (XRD) data using FullProf software whereas crystallite size and lattice strain were estimated from Williamson-Hall approach. XRD analysis of the compound indicated the formation of a single-phase cubic structure with the space group Pm m. Dielectric study revealed that the compound 0.75Ba(Sm1/2Nb1/2)O3-0.25BaTiO3 is having low and and a low TCC (< 5%) in the working temperature range (up to + 100 C) which makes this composition suitable for capacitor application and may be designated as ‘Stable Low-K’ Class I material as per the specifications of the Electronic Industries Association. The correlated barrier hopping model was employed to successfully explain the mechanism of charge transport in the system. The ac conductivity data were used to evaluate the density of states at Fermi level, minimum hopping length and apparent activation energy of the compounds.
Mie Scattering of Electromagnetic Waves

Scattering of electromagnetic waves by spherical particles is described by the Mie solution to Maxwell’s equations. Illumination of an obstacle by an electromagnetic wave excites electric charges in the obstacle to oscillate due to interaction with the electric field of the incident wave. The oscillating charge radiates electromagnetic energy in all directions; this secondary radiation is the radiation scattered by the obstacle. In addition, the excited elementary charges may absorb radiation and transform part of the incident energy into other forms, such as thermal energy. Both scattering and absorption remove energy from a beam of light and the beam is attenuated. In this work, scattering of an incident electromagnetic wave by a spherical particle has been analyzed using COMSOL Multiphysics. The nature of the interaction has been considered for materialswith three different properties: metallic, magnetic and dielectric. The solutions provide details of the absorption, scattering, extinction, pressure cross-sections, backscattering and radiation force exerted on the particle by an incident plane wave.Results of these analyses are compared against the Mie analytical solutions.
Metabolic syndrome

ABSTRACT: Hirsutism is a finding that can lead to subsequent metabolic diagnoses such as the metabolic syndrome. Metabolic syndrome describes a cluster of cardiometabolic risk factors associated with overweight and obesity. Although it has been the subject of some controversy, perhaps due to the many definitions proposed by different health organizations, metabolic syndrome is clinically relevant in that it is a predictor of vascular risk, even independent of any associated type 2 diabetes. While various definitions may differ in precise cut‐off points, they uniformly emphasize key pathophysiologic processes: visceral obesity, dyslipidemia, insulin resistance, and hypertension. Management of metabolic syndrome focuses on methods of reducing the component risk factors, and therapies thus target the above processes as well as controlling inflammation and the prothrombotic state. Treatments can include not only pharmacologic approaches but behavior modification as well.
A review on damage detection methods and stacking sequence optimization in polymer matrix composite materials under low velocity impact

Optimization is the most essential criteria in the structural design process. In the composite structure design process one must deal with many design variables such as number of layers, plate thickness and orientation of laminate. In this paper an overview on the optimization of stacking sequences in the polymer matrix composite material (PMC) from the latest literature is illustrated. Occurrence of damage by low velocity impact in polymer matrix composites are detected by using various detection methods is briefly described. In damage detection, the image segmentation techniques will be useful for the future researches. The purpose of this work is to do a literature study and finding the significant research gap by comparison of various optimization methods and damage detection methods.
Bending Analysis of Smart Composite Laminated Plates Subjected To Electro-Mechanical Loading By Using ‘ HOSDT ’ *

Abstract: The present paper involves the investigation of bending response of smart composite plates by using a new higher order shear deformation theory (HOSDT). A piezoelectric fiber reinforced composite materials are used as a distributed sensors or actuators to analyze the performance of the smart plates. A higher order shear deformation theory is proposed for piezoelectric laminated composite plates subjected to electro mechanical loading. The displacement model is considered and the equations of equilibrium are attained by using the principle of virtual work and the solutions are evaluated with Navier’s technique. The displacements and stresses due to bending are analyzed.
Mutually Compactificable Topological Spaces

Two disjoint topological spaces X, Y are (T2-) mutually compactificable if there exists a compact (T2-) topology on K=X∪Y which coincides on X, Y with their original topologies such that the points x∈X, y∈Y have open disjoint neighborhoods in K. This paper, the first one from a series, contains some initial investigations of the notion. Some key properties are the following: a topological space is mutually compactificable with some space if and only if it is θ-regular. A regular space on which every real-valued continuous function is constant is mutually compactificable with no S2-space. On the other hand, there exists a regular non-T3.5 space which is mutually compactificable with the infinite countable discrete space.
Uremic Medium Disturbs the Hemostatic Balance of Cultured Human Endothelial Cells

Summary We have investigated the ability of serum from uremic patients to modify the thrombogenic properties of the endothelium. The effects of uremic medium on the morphology of endothelial cells (ECs), and their resistance to flow was analyzed. The influence of uremic media on the reactivity of the extracellular matrix (ECM) generated by ECs towards normal platelets was evaluated in a parallel-plate perfusion chamber. Exposure of ECs to uremic medium resulted in abnormal cell morphology and signs of an accelerated growth. Detachment of ECs exposed to circulating blood was increased when cells had been grown with media supplemented with uremic serum (21% vs. 14% non exposed). Platelet deposition was significantly elevated on ECMs generated in the presence of uremic media (uremicECMs) (p<0.01 vs. control studies). Effects of uremic serum were not observed at short incubation periods (5 h) but were evident after 24 or 72 h of incubation. Northern blot analysis revealed increased expression of tissue factor (TF) mRNA in ECs exposed to uremic conditions. Immunocytochemical methods detected an augmented expression of TF antigen on uremic ECMs. Incubation of ECMs with an antibody to human tissue factor prevented the increase in platelet deposition observed in uremic ECMs, suggesting that the presence of TF in ECM could be responsible for the enhanced platelet deposition. Results from our study indicate that uremic medium impairs the antithrombotic functions of cultured endothelial cells.
Effect of vibration on pain during Injection of local anesthesia: A split-mouth randomized clinical trial

Vibration can reduce pain. This study was conducted to use this effect while injecting dental anesthesia. This splitmouth randomized clinical trial was performed on 40 injection sites from 20 patients. In the experimental sides, the turned-on device would be positioned in contact with the injection area for 5 seconds; then the anesthesia would be administered, while the device was in place; fi nally, the device would remain in place for 5 seconds after removing the needle. In the control sides, the device would be placed on the mucosa in a similar fashion but turned off. Immediately after removing the tip of Dental Vibe, patients were asked to rate their pain using Wong Baker method. Pain scores were compared statistically. Average pain levels in the experimental and control sides were 1.95 ± 1.57 (95% CI: 1.22 to 2.68) and 0.65 ± 0.81 (95% CI: 0.27 to 1.03), respectively. Their difference was signifi cant according to Wilcoxon test (P < 0.001). Age (P = 0.670), injection type (P = 0.175), and sex (P = 0.160) did not affect the response to the Dental Vibe signifi cantly, according to chi-square test. Dental Vibe is a useful and effective device in reducing pain while injecting local anesthesia. 728 ARTICLE INFORMATION: *Corresponding Author: Received 10th Oct, 2017 Accepted after revision 29th Dec, 2017 BBRC Print ISSN: 0974-6455 Online ISSN: 2321-4007 CODEN: USA BBRCBA Thomson Reuters ISI ESC and Crossref Indexed Journal NAAS Journal Score 2017: 4.31 Cosmos IF: 4.006 © A Society of Science and Nature Publication, 2017. All rights
Subject expectations of treatment effectiveness and outcome of treatment with an experimental antidepressant.

OBJECTIVE To evaluate the association between treatment expectations and response in a 9-week, single-blind experimental antidepressant treatment study. METHOD Twenty-five adult subjects meeting DSM-IV criteria for major depressive disorder with Hamilton Rating Scale for Depression (HAM-D) scores of >/= 17 completed a treatment trial using the experimental antidepressant reboxetine. Following a 1-week placebo lead-in, subjects received single-blind treatment for 8 weeks with reboxetine 8 to 10 mg/day. During the screening visit, subjects were asked to self-rate their expectations of the effectiveness of the study medication. Forced-choice responses were "not at all effective," "somewhat effective," or "very effective. " Response to treatment was defined as a final HAM-D score of </= 10 at the end of the 9-week trial. Data were collected from October 1999 to July 2001. RESULTS Subjects with a higher pretreatment expectation of medication effectiveness had a greater likelihood of response. Of the subjects who reported an expectation that the medication would be very effective, 90.0% (N = 9) responded to treatment, while only 33.3% (N = 5) of those who reported expecting medication to be somewhat effective responded to treatment (chi(2) = 7.819, p <. 005). There was no association between the level of depression severity, duration of current episode, number of prior episodes, or basic demographic factors and treatment outcome. CONCLUSIONS These findings indicate that individuals with high baseline expectations of improvement demonstrate a significantly higher level of response to reboxetine than those with lower expectations of improvement with treatment. The data in this study suggest that a subject's expectation of efficacy is associated with the outcome of experimental antidepressant treatment.
Numerical investigation of the Delft Jet in Hot-Coflow burner with EDC model and chemistry reduction in OpenFOAM

Moderate or Intense Low oxygen Dilution (MILD) combustion technology has gained increasing attention for the past few decades [1]. It is characterized by very strong mixing between the reactant and product. As a result, the fuel conversion rate is higher and the temperature field is more uniform than that in conventional combustion regime, thereby reducing the CO, soot and NOX emissions [1, 2]. Due to the intensive mixing and reduced peak temperatures, the reactivity of MILD combustion is reduced. Therefore, chemical kinetics becomes the controlling parameter in the combustion process [3]. This makes it important to include detailed chemistry in the modelling of such flames. In the present work, the Eddy Dissipation Concept (EDC) combustion model is considered, in combination with detailed chemistry. The Tabulation of Dynamic Adaptive Chemistry (TDAC) reduction method is introduced to alleviate the long calculation time associated with high number of species and reactions. Results from a validation test case of Delft Jet in Hot Co-flow (DJHC) burner are shown and discussed.
Influence of moisture on the estimation of nonlinear parameters in concrete with Nonlinear ultrasonic Coda Wave Interferometry

Experiments dedicated to the condition assessment of concrete under stress (1, 2), crack sizing (3, 4) and crack healing monitoring (5) have shown that Nonlinear ultrasonic Coda Wave Interferometry (NCWI) is a very sensitive technique that can be used in the lab as well as in the field (6). This technique belongs to the family of nonlinear techniques that uses pump-probe experimental set-ups. The probe wave is the coda wave (in a frequency range where the wavelengths are smaller than the average aggregate size, typically above 200 kHz, and can propagate to decimeter distances, typically below 800 kHz). The pump wave is a high amplitude low frequency sweep chosen to insonify uniformly the sample under (typically below 50 kHz). The nonlinear acoustic behavior observed in concrete is linked to the interface between aggregate and mortar, micro-cracks, porosity, etc. In this paper we try to quantify and explain the role and influence of moisture when attempting to quantify the hysteretic non classic nonlinear acoustic parameters measured by NCWI. An experiment on a slab in a controlled environment with permanent monitoring of moisture content is conducted during several hours while water propagates inside the sample. In this paper the repeatability of the experiment is demonstrated and the diminution of the value of the acoustic nonlinear parameters with water ingress is quantified.
Superoxide radical and superoxide dismutases.

O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then reduce H2O2 to OH- +OH. SODs inhibit such HO. production by scavengingO2-, but Cu, ZnSODs, by virtue of a nonspecific peroxidase activity, may peroxidize spin trapping agents and thus give the appearance of catalyzing OH. production from H2O2. There is a glycosylated, tetrameric Cu, ZnSOD in the extracellular space that binds to acidic glycosamino-glycans. It minimizes the reaction of O2- with NO. E. coli, and other gram negative microorganisms, contain a periplasmic Cu, ZnSOD that may serve to protect against extracellular O2-. Mn(III) complexes of multidentate macrocyclic nitrogenous ligands catalyze the dismutation of O2- and are being explored as potential pharmaceutical agents. SOD-null mutants have been prepared to reveal the biological effects of O2-. SodA, sodB E. coli exhibit dioxygen-dependent auxotrophies and enhanced mutagenesis, reflecting O2(-)-sensitive biosynthetic pathways and DNA damage. Yeast, lacking either Cu, ZnSOD or MnSOD, are oxygen intolerant, and the double mutant was hypermutable and defective in sporulation and exhibited requirements for methionine and lysine. A Cu, ZnSOD-null Drosophila exhibited a shortened lifespan.
FVC and FEV Reference Values for Beninese Individuals Aged 17 - 20 Years

Background: 1) To determine forced vital capacity (FVC) and forced expiratory volume in one second (FEV) for Beninese individuals of both sexes aged 17 - 20 years; 2) Compare the observed values to those calculated based on the algorithms of the spirometer used. Materials and Methods: The FVC and FEV values were first measured using a Micro Quark spirometer and then calculated from equations for the European Respiratory Society-93 (ERS-93) in 148 subjects, including 46 girls. In each age group, the measured values for the height of the subjects were considered the only variables used to calculate the equations for FVC and FEV with their 95% confidence intervals. The means of the FEV and FVC values were obtained by univariate analysis. Results: The calculated FEV and FVC values were significantly higher (p < 0.05) than those observed by spirometry. Conclusion: The correction factors incorporated in spirometers imported from Europe no longer seem appropriate to measure the physical characteristics of African subjects. The differences between the two methods of assessment should be used as new ethnic correction factors.
Clinical reviews about Overall Incidence of Adverse Effects in Amiodarone Treatment

Amiodarone is a effective agent for the treatment of many cardiac rhythm disturbances, ranging from paroxysmal atrial fibril lation to intractable ventricular tachyarrhythmias. However, amiodarone causes variable adverse effects from minor to life threatening. The aim of this study was to review general incidence of and associated factors with the adverse effects of amiodarone medication. Eight hundred seventy six patients who had taken amiodarone regularly over three months or who stopped medication due to any adverse effect between November 1996 and March 2005 at Keimyung University Dongsan medical center were included. Ninty six patients (11.0%) developed the amiodarone toxicity in any type. Among them, 60 patients showed hypothyroidism and held 62.5%. 10 patients showed pulmonary toxicity and held 10.4%, 20 patients and 20.8%, 6 patients and 6.3%. Patients with toxicity were older than patients without toxicity as 65.1±12.1 and 61.9±13.4 yr (p=0.026). Total dose and duration of amiodarone medication in the toxicity group were 1615.4±1414.6 gm and 734.9±677.1 days and 565.4±668.1 gm and 1249.7±1411.6 days in non-toxicity group respectively. The incidence of amiodarone induced toxicity was generally lower than established reports. If we had done regular protocol for checking up amiodarone adverse effects, we could detect amiodarone induced toxicity more exactly. It suggests that an incidence of amiodarone induced adverse effects can be lessened and the toxicity is prevented to some degree treating patients with amiodarone more carefully and performing a regular follow up protocol during medication.
Structured Nonsense : Automatic Imitation of Writing Style

In this report we present a system designed to generate nonsense sentences in a specified style. A style is defined implicitly by providing a set of training documents (e.g. books written by a single author) and the system extracts the necessary information to mimic structural properties of the text. We quantify our success in the style mimicry task by measuring the ability of our system to fool a standard stylometric evaluation tool.
Employee Perceptions in the Workplace : Discrimination , Work Motivation , Teamwork / Citizenship , and Locus of Control

Research regarding discrimination is plentiful with a general understanding that it can induce stress, prevent access to opportunities, and affect interpersonal relationships (Jang, Chiriboga, & Small, 2008; Miller & Kaiser, 2001). However, research has not yet clarified a relationship between perceived discrimination with other constructs such as work motivation, teamwork/citizenship, and locus of control (LOC). For that reason, the purpose of this study will be to explore those relationships. A sample of 443 participants completed an online survey containing a series of demographic questions, a set of questions regarding the participant’s perception of having been discriminated against, as well as valid and reliable measures of the constructs: work motivation, teamwork/citizenship, and LOC. This was done using a convenience, snowball sampling technique, limited to employed individuals 18 years or older. The results showed that individuals who perceived discrimination had, on average, higher LOC scores (x = 44.88) than those who did not perceive discrimination (x = 39.70). This indicates a higher external LOC score for those who perceived discrimination; meaning they were more likely to see themselves as victims of circumstances beyond their control. However, no significance was found in comparing those who perceived discrimination and those who didn’t with the constructs of work motivation and teamwork/citizenship. This study will contribute to the body of knowledge on perceived discrimination by providing additional insight on its relationship with work motivation, teamwork/citizenship, and LOC.
Borderline Personality Disorder and Traits in Veterans: Psychiatric Comorbidity, Healthcare Utilization, and Quality of Life Along a Continuum of Severity

ABSTRACT Objective: To examine the presence of borderline personality disorder (BPD) traits in Gulf War veterans, and to assess psychiatric comorbidity, health status, healthcare utilization, and quality of life (QOL) along a continuum of BPD trait severity. Method: BPD and traits were evaluated using the Schedule for Non-Adaptive and Adaptive Personality in 576 veterans who were either deployed to the Persian Gulf (1990–1991) or were on active duty though not deployed to the Gulf. Demographic and military characteristics, personal and family history, psychiatric comorbidity, and QOL were also assessed. Results: One or more BPD traits were present in 247 subjects (43%), and BPD (≥5 traits) was identified in 15 subjects (3%). The number of traits was significantly associated with age and level of education. Lifetime psychiatric comorbidity was significantly associated with the number of BPD traits present, and level of functioning, health status, healthcare utilization, social functioning, self-injurious tendencies, and military/behavioral problems. Conclusion: BPD and traits identified in Gulf War veterans were associated with significant psychiatric morbidity, poorer QOL, and increased utilization of healthcare resources. Early recognition and treatment of veterans with BPD symptoms may be warranted to minimize the burden on the healthcare system.