Miracle-dz/UniFAR-FTUs huggingface dataset:
Acquired von Willebrand Syndrome in a Child Following Berlin Heart EXCOR Pediatric Ventricular Assist Device Implantation

The development of acquired von Willebrand syndrome (AVWS) after placement of a pulsatile-flow left ventricular assist device (LVAD) is rare and only recently recognized. We report the case of a young infant who was diagnosed with ventricular assist device (VAD)-related AVWS following implantation of a Berlin Heart EXCOR Pediatric Ventricular Assist Device (Berlin Heart Inc., The Woodlands, Texas, USA) for treatment of severe heart failure. Despite significant bleeding, the patient was successfully managed with von Willebrand factor-containing concentrate until VAD explantation led to definitive resolution of the AVWS. This case demonstrates that the possibility of this diagnosis should be considered in pediatric patients when extensive, nonsurgical bleeding is encountered after pulsatile-flow VAD implantation.
The Effect of Wrinkles, Presentation Mode, and Intensity on the Perception of Facial Actions and Full-Face Expressions of Laughter

This article focuses on the identification and perception of facial action units displayed alone as well as the meaning decoding and perception of full-face synthesized expressions of laughter. We argue that the adequate representation of single action units is important in the decoding and perception of full-face expressions. In particular, we focus on three factors that may influence the identification and perception of single actions and full-face expressions: their presentation mode (static vs. dynamic), their intensity, and the presence of wrinkles. For the purpose of this study, we used a hybrid approach for animation synthesis that combines data-driven and procedural animations with synthesized wrinkles generated using a bump mapping method. Using such animation technique, we created animations of single action units and full-face movements of two virtual characters. Next, we conducted two studies to evaluate the role of presentation mode, intensity, and wrinkles in single actions and full-face context-free expressions. Our evaluation results show that intensity and presentation mode influence (1) the identification of single action units and (2) the perceived quality of the animation. At the same time, wrinkles (3) are useful in the identification of a single action unit and (4) influence the perceived meaning attached to the animation of full-face expressions. Thus, all factors are important for successful communication of expressions displayed by virtual characters.
The Effect of Selenium Therapy on Mortality in Patients With Sepsis Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials*

Background:Patients with sepsis syndrome commonly have low serum selenium levels. Several randomized controlled trials have examined the efficacy of selenium supplementation on mortality in patients with sepsis. Objective:To determine the efficacy and safety of high-dose selenium supplementation compared to placebo for the reduction of mortality in patients with sepsis. Sources of Data:We searched Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, SciFinder, and Clinicaltrials.gov. Selection Criteria:Randomized controlled parallel group trials comparing selenium supplementation in doses greater than daily requirement to placebo on the outcome of mortality in patients with sepsis syndrome. Data Collection and Analysis:Two reviewers independently applied eligibility criteria, assessed quality, and extracted data. The primary outcome was mortality; secondary outcomes were ICU length of stay, nosocomial pneumonia, and adverse events. Trial authors were contacted for additional or clarifying information. Results:Nine trials enrolling a total of 792 patients were included. Selenium supplementation in comparison to placebo was associated with lower mortality (odds ratio, 0.73; 95% CI, 0.54, 0.98; p = 0.03; I2 = 0%). Among patients receiving and not receiving selenium, there was no difference in ICU length of stay (mean difference, 2.03; 95% CI, –0.51, 4.56; p = 0.12; I2 = 0%) or nosocomial pneumonia (odds ratio, 0.83; 95% CI, 0.28, 2.49; p = 0.74; I2 = 56%). Significant heterogeneity among trials in adverse event reporting precluded pooling of results. Conclusions:In patients with sepsis, selenium supplementation at doses higher than daily requirement may reduce mortality. We observed no impact of selenium on ICU length of stay or risk of nosocomial pneumonia.
Beyond risk, resilience, and dysregulation: Phenotypic plasticity and human development

Abstract We provide a theoretical and empirical basis for the claim that individual differences exist in developmental plasticity and that phenotypic plasticity should be a subject of study in its own right. To advance this argument, we begin by highlighting challenges that evolutionary thinking poses for a science of development and psychopathology, including for the diathesis–stress framework that has (fruitfully) guided so much empirical inquiry on developmental risk, resilience, and dysregulation. With this foundation laid, we raise a series of issues that the differential-susceptibility hypothesis calls attention to, while highlighting findings that have emerged over just the past several years and are pertinent to some of the questions posed. Even though it is clear that this new perspective on Person × Environment interaction is stimulating research and influencing how hypotheses are framed and data interpreted, a great many topics remain that need empirical attention. Our intention is to encourage students of development and psychopathology to treat phenotypic plasticity as an individual-difference construct while exploring unknowns in the differential-susceptibility equation.
Toward "Third Wave" Information Systems Research: Linking Sociomaterial Practice with Broader Institutional Logics

The sociomaterial movement has done much to strengthen the theorizing of IT artifacts in practice. This “second wave” information systems research, which focuses on theorizing of the interpenetration of IT artifacts and human activity, is a response to the positivistic, reductive accounts that overly simplified human activity around the development and adoption of IT in the name of generalizability. However, with their focus on local ideographic interpretation, sociomaterial views have abandoned the search for regularities across contexts and across time. In this paper, we take a step toward a “third wave” approach as we look to theoretically account for both idiosyncrasies in sociomaterial practice in situ, and the regularities across these practices. Drawing on institutional logics and the concept of sociomaterial practice, we develop a conceptualization that highlights how technologies afford the enactment of different practice scripts as users draw on different institutional logics.
Approches technico-économiques d’optimisation des systèmes énergétiques décentralisés

Le developpement des systemes energetiques renouvelables et/ou conventionnels pour l’alimentation des zones decentralisees est confronte a de multiples barrieres techniques, institutionnelles, socioculturelles et surtout financieres. La solution defendue dans cette these est de rechercher des approches pour concevoir des systemes durables et rentables, conditions requises pour le developpement de l’electrification rurale par le secteur prive. L’analyse des differents criteres economiques permet tout d’abord de definir plusieurs types d’equivalence entre criteres economiques : equivalence decisionnelle, equivalence pour le dimensionnement optimal et equivalence pour le classement des solutions techniques. Cette premiere etude permet de demontrer que les 3 criteres economiques habituellement utilises (le LCOE, le taux de rentabilite interne, et le temps de retour sur investissement) aboutiront a des solutions techniques optimales differentes. Un modele technico-economique est alors developpe pour les systemes hybrides PV/Diesel sans batteries de stockage en site isole. Une application au site 2iE-K1 (Ouagadougou) permet de valider la conformite des modeles par comparaison au logiciel HOMER. On montre que les criteres de taux de rentabilite interne maximum ou de temps de retour sur investissement minimum limitent l’investissement et le montant de la dette maximale. Plusieurs solutions optimales, dependant du critere economique considere, sont alors proposees pour un cas d’application reel : l’electrification de la localite rurale de Bilgo. Le travail realise au cours de cette these se situe donc dans la branche des outils de dimensionnement optimal et d’optimisation technico-economique des systemes de production decentralisee d’energie.
Quantum dot‐based protein micro‐ and nanoarrays for detection of prostate cancer biomarkers

In this article, we demonstrate the fabrication and detection of cancer protein biochips consisting of micro‐ and nanoarrays whereby pegylated quantum dots (QDs) conjugated to antibodies (Abs) of prostate specific antigens (PSA) were used for the detection of clinical biomarkers such as PSA. BSA which acts as an efficient blocking layer in microarrays, tends to show an interaction with QDs. In view of this fact, we investigated two series of samples which were fabricated in the presence and absence of BSA blocking layer. Variation in the incubation time required for the antigen–antibody interaction to take place, different proteins as controls and the effect of bare QDs on these microarrays, were the three main parameters which were studied in these two series. Samples fabricated in the absence of BSA blocking layer exhibited an extremely high specificity in the detection of cancer proteins and were also marked by negligible nonspecific binding effects of QDs, in stark contrast to the samples fabricated using BSA as a blocking layer. Fabrication of nanoarrays of QD‐conjugated PSA Abs having a spot size of nearly 900 nm has also been demonstrated. Thus, we show the potential offered by QDs in in vitro analysis of cancer biomarker imaging.
Multi-isotope labelling of organic matter by diffusion of 2H/18O-H2O vapour and 13C-CO2 into the leaves and its distribution within the plant

Abstract. Isotope labelling is a powerful tool to study elemental cycling within terrestrial ecosystems. Here we describe a new multi-isotope technique to label organic matter (OM). We exposed poplars (Populus deltoides × nigra) for 14 days to an atmosphere enriched in 13CO2 and depleted in 2H218O. After 1 week, the water-soluble leaf OM (δ13C = 1346 ± 162‰) and the leaf water were strongly labelled (δ18O = −63 ± 8, δ2H = −156 ± 15‰). The leaf water isotopic composition was between the atmospheric and stem water, indicating a considerable back-diffusion of vapour into the leaves (58–69%) in the opposite direction to the net transpiration flow. The atomic ratios of the labels recovered (18O/13C, 2H/13C) were 2–4 times higher in leaves than in the stems and roots. This could be an indication of the synthesis of more condensed compounds in roots and stems (e.g. lignin vs. cellulose) or might be the result of O and H exchange and fractionation processes during phloem transport and biosynthesis. We demonstrate that the three major OM elements (C, O, H) can be labelled and traced simultaneously within the plant. This approach could be of interdisciplinary interest in the fields of plant physiology, palaeoclimatic reconstruction or soil science.
A 0.57°/h bias instability 0.067°/√h angle random walk MEMS gyroscope with CMOS readout circuit

This paper demonstrates a SOI MEMS vibratory gyroscope with a fully differential CMOS readout circuit in a standard 0.35-μm process. Wafer level vacuum packaging technique and thick SOI structure layer are employed to increase the mechanical sensitivity. With ultra-low noise drive and sense front-ends, and an automatic amplitude control circuit realized with chopper stabilization technique and a transconductance boosted error amplifier, the fabricated gyroscope achieves 0.5°/h bias instability and 0.067°/√h angle random walk. Operating in split mode, the gyroscope achieves 200Hz bandwidth and a nonlinearity of 1355ppm with a full scale of ±300°/s. The overall power consumption is 2.1mW under a 1.8 V supply.
Product family testing: a survey

In this paper we discuss the current state of product family testing. Testing, unlike other areas of software development, has received only little attention in this context despite the problems directly rising from scale, reuse and variability. We present the current approaches to product family testing methodology and processes. We also evaluate the current state-of-the-art in product family testing and highlight problems that need to be addressed in the future.
Cluster Validity Through Graph-based Boundary Analysis

Gaining confidence that a clustering algorithm has produced meaningful results and not an accident of its usually heuristic optimization is central to data mining. This is the issue of cluster validity. We propose here a method by which proximity graphs are used to effectively detect border points and measure the margin between clusters. With analysis of boundary situation, we design a framework and relevant working principles to evaluate the separation and compactness in the clustering results. The method can obtain an insight into the internal structure in clustering result.
Metric embeddings with relaxed guarantees

We consider the problem of embedding finite metrics with slack: we seek to produce embeddings with small dimension and distortion while allowing a (small) constant fraction of all distances to be arbitrarily distorted. This definition is motivated by recent research in the networking community, which achieved striking empirical success at embedding Internet latencies with low distortion into low-dimensional Euclidean space, provided that some small slack is allowed. Answering an open question of Kleinberg, Slivkins, and Wexler (2004), we show that provable guarantees of this type can in fact be achieved in general: any finite metric can be embedded, with constant slack and constant distortion, into constant-dimensional Euclidean space. We then show that there exist stronger embeddings into /spl lscr//sub 1/ which exhibit gracefully degrading distortion: these is a single embedding into /spl lscr//sub 1/ that achieves distortion at most O(log 1//spl epsi/) on all but at most an /spl epsi/ fraction of distances, simultaneously for all /spl epsi/ > 0. We extend this with distortion O(log 1//spl epsi/)/sup 1/p/ to maps into general /spl lscr//sub p/, p /spl ges/ 1 for several classes of metrics, including those with bounded doubling dimension and those arising from the shortest-path metric of a graph with an excluded minor. Finally, we show that many of our constructions are tight, and give a general technique to obtain lower bounds for /spl epsi/-slack embeddings from lower bounds for low-distortion embeddings.
Fundamental Studies And Applications Of Strong Field Ionization

72 Autobiographical Statement . 73
DISTRIBUTION STATEMENT A : Unlimited Distribution Computer Vision Techniques Applied to Space Object Detect , Track , ID , and Characterize

Space-based object detection and tracking represents a fundamental step necessary for detailed analysis of space objects. Initial observations of a resident space object (RSO) may result from careful sensor tasking to observe an object with well understood dynamics, or measurements-of-opportunity on an object with poorly understood dynamics. Dim and eccentric objects present a particular challenge which requires more dynamic use of imaging systems. As a result of more stressing data acquisition strategies, advanced techniques for the accurate processing of both point and streaking sources are needed. This paper will focus on two key methods in computer vision used to determine interest points within imagery. The Harris Corner method and the method of Phase Congruency can be used to effectively extract static and streaking point sources, and to indicate when apparent motion is present within an observation. The geometric inferences which can be made from the resulting detections will be discussed, including a method to evaluate the localization uncertainty of the extracted detections which is based on the computation of the Hessian of the detector response. Finally, a technique which exploits the additional information found in detected streak endpoints to provide a better centroid in the presence of curved star streaks is explained and additional applications for the presented techniques are discussed.
pH-Dependent Inhibition of Kainate Receptors by Zinc

Kainate receptors contribute to synaptic plasticity and rhythmic oscillatory firing of neurons in corticolimbic circuits including hippocampal area CA3. We use zinc chelators and mice deficient in zinc transporters to show that synaptically released zinc inhibits postsynaptic kainate receptors at mossy fiber synapses and limits frequency facilitation of kainate, but not AMPA EPSCs during theta-pattern stimulation. Exogenous zinc also inhibits the facilitatory modulation of mossy fiber axon excitability by kainate but does not suppress the depressive effect of kainate on CA3 axons. Recombinant kainate receptors are inhibited in a subunit-dependent manner by physiologically relevant concentrations of zinc, with receptors containing the KA1 subunit being sensitive to submicromolar concentrations of zinc. Zinc inhibition does not alter receptor desensitization nor apparent agonist affinity and is only weakly voltage dependent, which points to an allosteric mechanism. Zinc inhibition is reduced at acidic pH. Thus, in the presence of zinc, a fall in pH potentiates kainate receptors by relieving zinc inhibition. Acidification of the extracellular space, as occurs during repetitive activity, may therefore serve to unmask kainate receptor neurotransmission. We conclude that zinc modulation of kainate receptors serves an important role in shaping kainate neurotransmission in the CA3 region.
Utilizing Contextually Relevant Terms in Bilingual Lexicon Extraction

This paper demonstrates one efficient technique in extracting bilingual word pairs from non-parallel but comparable corpora. Instead of using the common approach of taking high frequency words to build up the initial bilingual lexicon, we show contextually relevant terms that co-occur with cognate pairs can be efficiently utilized to build a bilingual dictionary. The result shows that our models using this technique have significant improvement over baseline models especially when highest-ranked translation candidate per word is considered.
An RDF Dataset Generator for the Social Network Benchmark with Real-World Coherence

Synthetic datasets used in benchmarking need to mimic all characteristics of real-world datasets, in order to provide realistic benchmarking results. Synthetic RDF datasets usually show a significant discrepancy in the level of structuredness compared to real-world RDF datasets. This structural difference is important as it directly affects storage, indexing and querying. In this paper, we show that the synthetic RDF dataset used in the Social Network Benchmark is characterized with high-structuredness and therefore introduce modifications to the data generator so that it produces an RDF dataset with a real-world structuredness.
Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha‐synuclein in oligodendrocytes

Mice overexpressing human alpha‐synuclein in oligodendrocytes (MBP1‐α‐syn) recapitulate some key functional and neuropathological features of multiple system atrophy (MSA). Whether or not these mice develop severe autonomic failure, which is a key feature of human MSA, remains unknown. We explored cardiovascular autonomic regulation using long‐term blood pressure (BP) radiotelemetry and pharmacological testing. We instrumented 12 MBP1‐α‐syn mice and 11 wild‐type mice aged 9 months for radiotelemetry. Animals were tested with atropine, metoprolol, clonidine, and trimethaphan at 9 and 12 months age. We applied spectral and cross‐spectral analysis to assess heart rate (HR) and BP variability. At 9 months of age daytime BP (transgenic: 101 ± 2 vs. wild type: 99 ± 2 mmHg) and HR (497 ± 11 vs. 505 ± 16 beats/min) were similar. Circadian BP and HR rhythms were maintained. Nighttime BP (109 ± 2 vs. 108 ± 2 mmHg) and HR (575 ± 15 vs. 569 ± 14 beats/min), mean arterial BP responses to trimethaphan (−21 ± 8 vs. −10 ± 5 mmHg, P = 0.240) and to clonidine (−8 ± 3 vs. −5 ± 2 mmHg, P = 0.314) were similar. HR responses to atropine (+159 ± 24 vs. +146 ± 22 beats/min), and to clonidine (−188 ± 21 vs. −163 ± 33 beats/min) did not differ between strains. Baroreflex sensitivity (4 ± 1 vs. 4 ± 1 msec/mmHg) and HR variability (total power, 84 ± 17 vs. 65 ± 21 msec²) were similar under resting conditions and during pharmacological testing. Repeated measurements at 12 months of age provided similar results. In mice, moderate overexpression of human alpha‐synuclein in oligodendrocytes is not sufficient to induce overt autonomic failure. Additional mechanisms may be required to express the autonomic failure phenotype including higher levels of expression or more advanced age.
Efficient Cost-Based Tracking of Scheduled Vehicle Journeys

Applications in areas such as logistics, cargo delivery, and collective transport involve the management of fleets of vehicles that are expected to travel along known routes according to schedules. There is a fundamental need by the infrastructure surrounding the vehicles to know the actual status of the vehicles. Since the vehicles deviate from their schedules due to road construction, accidents, and other unexpected conditions, it is necessary for the vehicles to communicate with the infrastructure. Frequent updates introduce high communication costs, and server-side updates easily become a bottleneck. This paper presents techniques that enable the tracking of vehicle positions and arrival times at scheduled stops with little communication, while still offering the desired accuracy to the infrastructure of the status of the vehicles. Experimental results with real GPS data from buses show that the proposed techniques are capable of reducing the number of updates significantly compared to a state-of-the art approach where vehicles issue updates at pre-defined positions along their routes.
Study on Action and Attribute-Based Access Control Model for Web Services

For the fact that traditional Access Control models are mostly static, coarsely grained, and not well suited for solving the application in the security of web services. This paper extends access control models by introducing actions based on attribute-based access control. The model avoids the complex structure of multi-attribute and solves the problem that relevant dynamic authorization and permission changes. This paper structures the model by using SAML and XACML. The implementation of this model is given through examples.