Miracle-dz/UniFAR-FTUs huggingface dataset:
The Mediating Role of Organizational-Based Self-Esteem in Training-Commitment Relationship

i ACKNOWLEDGEMENTS I would like to express my deepest gratitude to Professor Anne Marie Francesco, the supervisor of my honors project, for her generous and valuable guidance in the research process. Her insights and supports have inspired me to carry out the project in a great success. the founders of the organizational-based self-esteem questionnaire. Their kindness of the provision of the original questionnaires has smoothed the research process. Credits should also be given to my friends and fellow classmates, who gave precious advices on my project and assisted me in collecting questionnaires. Lastly, I would like to acknowledge all respondents in completing the questionnaires. Their cooperation was critical to the success of the project. This study investigates the relationships between the provision of training by organizations and affective, continuance and normative commitment, as well as the mediating role of organizational-based self-esteem in these relationships. Based on a sample of 111 full-time employees from 10 different organizations in Hong Kong, training frequency is a significant predictor of affective and continuance commitment, and organizational-based self-esteem mediates the relationships. Training duration is not related neither to affective, nor continuance and normative commitment. The findings are discussed for their implications of practical application to organizations and for advancement of future research on this topic. Background Since the early 1990s, mergers, re-engineering, and downsizing of firms have been predominating and job security for employees has completely died out nowadays. As the traditional employment relationship in which employees exchange commitment to an organization for long-term employment has been undermined, organizations have to develop new ways of inspiring commitment among employees Problem Over the past few decades, researchers have been extensively studying antecedents of organizational commitment has focused on factors such as job satisfaction (Knights & Kennedy, 2005) and perceived organizational support (Vandenberghe, Bentein, & Stinglhamber, 2004), which cannot be controlled solely by human resources practice.
Linking Industry and Occupation Clusters in Regional Economic Development

Research to date suggests that occupation clusters may be at least as important as industry clusters in driving regional competitive advantage. A nationwide mapping of occupation clusters, with data available for every U.S. county and the capability to aggregate counties to a regional level, serves as a powerful complement to an understanding of industry clusters, the major focus of a previous EDA-funded project conducted by partners in this research team. This paper explains the importance of occupation cluster analysis, how 15 different occupation clusters were developed as part of this study, the results and products from the analysis, and the applications and implications of using occupation cluster analysis at the local and regional levels.
Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulatum

Infection with Histoplasma capsulatum results in a subclinical infection in immunocompetent hosts due to an effective cellular immune response. By contrast, immunodeficient individuals can have a severe disseminated and potentially fatal disease. In a previous study, it was demonstrated that normal mice infected intravenously with H. capsulatum and treated with interleukin-12 (IL-12) at the time of infection were protected from a fatal outcome. In this study, we examined the immunomodulatory effects of IL-12 on disseminated histoplasmosis in immunodeficient SCID mice. SCID mice infected with H. capsulatum and treated with IL-12 showed an increase in survival and a reduction in the colony counts of H. capsulatum in internal organs at 14 days after infection. The protective effect of IL-12 was abrogated if animals were also treated with a neutralizing antibody to gamma interferon (IFN-gamma). IL-12 treatment also resulted in an increase in mRNA expression and protein production for IFN-gamma, tumor necrosis factor alpha (TNF-alpha), and nitric oxide from spleen cells. When IL-12 was combined with amphotericin B (AmB) treatment, there was a significant increase in survival compared with either modality alone. Moreover, combined treatment resulted in an increase in both IFN-gamma and TNF-alpha production, as well as in a substantial reduction in H. capsulatum burden at 35 and 90 days postinfection. This study demonstrates that IL-12 modulates the protective immune response to histoplasmosis in SCID mice and also suggests that IL-12 in combination with AmB may be useful as a treatment for H. capsulatum in immunodeficient hosts.
An effect analysis of changes in the composition of the water ecological footprint in Jiangyin City, China

Ecological footprint (EF) analysis is an effective tool to assess ecosystem appropriation, but weaknesses still exist. In order to estimate a city's ecosystem appropriation, we made two modifications to EF: 1) including different types of freshwater area in the calculating framework; and 2) re-adjusting all equivalent factors in terms of different types of freshwater. The modifications are mainly concerned with changes in the composition of freshwater areas in EF analysis; that is, the proportion of aquaculture freshwater and tap freshwater. An assumption of 25% of aquaculture freshwater was used to conduct a sensitivity test. It shows that variation of the proportion leads to different equivalent and yield factors for tap freshwater areas. The variations not only change the EF of freshwater but also the total EF. The modified EF calculation served to assess ecosystem appropriation in Jiangyin city in 1998. By comparing the original and the modified EF, it was found that the ecological deficit was larger (2.19 ha per capita) in the modified calculation than in the original (2.16 ha per capita). The original calculation is an underestimate because direct consumption of freshwater was not fully included in its calculating framework. From the modified calculation, the EF for different categories of ecosystems decreased, from fossil energy land, arable land and pasture to built-up areas, which together occupy about 97.58% of the total EF. Fossil energy land occupied 68.55% of the total, while freshwater areas took only 0.62%. The main ecological deficits were from fossil energy land, arable land, pasture and marine areas. Ecological supply is lacking within Jiangyin and relies on ecosystems outside the city to survive. Ecosystem management is indispensable to optimise the efficiency of ecosystem use and to expand the biological capacity of the city. The modified EF could provide a more reasonable instrument in policy-making and implementing sustainable management of freshwater ecosystems.
Similarities and differences between male and female entrepreneurial attributes in manufacturing firms in the informal sector in the Transkei

Although South Africa has consistently registered positive economic growth rates since the democratic government took office in 1994, there has been no surge in new formal sector jobs. The public and private sectors have been shedding labour in response to economic imperatives of the domestic and global circumstances. Accordingly, more and more people are taking the route to informal sector entrepreneurship. Traditionally more men than women ventured into business; currently an increasing number of females are turning to self-employment. However, much that is known about business individuals is based on studies of male entrepreneurs. This article presents a comparative assessment of selected entrepreneurial attributes of male and female individuals engaged in informal sector manufacturing activities in the Transkei. Data were collected by means of a questionnaire administered to a sample of 80 micro-entrepreneurs in four urban centres. This study shows that the general entrepreneurial tendencies of the surveyed male and female micro-entrepreneurs are more similar than they are different. However, differences exist in value adding and job creation between the two groups.
MENTHO, a MLN64 Homologue Devoid of the START Domain*

MLN64 is a late endosomal membrane protein containing a carboxyl-terminal cholesterol binding START domain and is presumably involved in intracellular cholesterol transport. In the present study, we have cloned a human cDNA encoding a novel protein that we called MENTHO as an acronym for MLN64 N-terminal domain homologue because this protein is closely related to the amino-terminal half of MLN64. MLN64 and MENTHO share 70% identity and 83% similarity in an original protein domain encompassing 171 amino acids that we designated as the MENTAL (MLN64N-terminal) domain. By translation initiation scanning MENTHO is synthesized as two isoforms of 234 (α) and 227 (β) amino acids that can be phosphorylated. As MLN64, MENTHO is ubiquitously expressed and is located in the membrane of late endosomes, its amino and carboxyl-terminal extremities projecting toward the cytoplasm. We show that MENTHO overexpression does not rescue the Niemann-Pick type C lipid storage phenotype. However, MENTHO overexpression alters severely the endocytic compartment by leading at steady state to the accumulation of enlarged endosomes. These results indicate that in addition to its previously established function in addressing and anchoring proteins to the membrane of late endosomes, the MENTAL domain possesses an intrinsic biological function in endocytic transport.
Common elements in self-management of HIV and other chronic illnesses: an integrative framework

Abstract HIV/AIDS is widely recognized as a chronic illness within HIV care, but is often excluded from chronic disease lists outside the field. Similar to other chronic diseases, HIV requires lifetime changes in physical health, psychological functioning, social relations, and adoption of disease-specific regimens. The shift from acute to chronic illness requires a self-management model in which patients assume an active and informed role in healthcare decision making to change behaviors and social relations to optimize health and proactively address predictable challenges of chronic diseases generally and HIV specifically. This article reviews literature on chronic disease self-management to identify factors common across chronic diseases, highlight HIV-specific challenges, and review recent developments in self-management interventions for people living with HIV (PLH) and other chronic diseases. An integrated framework of common elements or tasks in chronic disease self-management is presented that outlines 14 elements in three broad categories: physical health; psychological functioning; and social relationships. Common elements for physical health include: a framework for understanding illness and wellness; health promoting behaviors; treatment adherence; self-monitoring of physical status; accessing appropriate treatment and services; and preventing transmission. Elements related to psychological functioning include: self-efficacy and empowerment; cognitive skills; reducing negative emotional states; and managing identity shifts. Social relationship elements include: collaborative relationships with healthcare providers; social support; disclosure and stigma management; and positive social and family relationships. There is a global need to scale up chronic disease self-management services, including for HIV, but there are significant challenges related to healthcare system and provider capacities, and stigma is a significant barrier to HIV-identified service utilization. Recognizing that self-management of HIV has more in common with all chronic diseases than differences suggests that the design and delivery of HIV support services can be incorporated into combined or integrated prevention and wellness services.
Fibrin: A Natural Biodegradable Scaffold in Vascular Tissue Engineering

Arterial occlusive disease remains a major health issue in the developed world and a rapidly growing problem in the developing world. Although a growing number of patients are now being effectively treated with minimally invasive techniques, there remains a tremendous pressure on the vascular community to develop a synthetic small-diameter vascular graft with improved long-term patency rates. The field of tissue engineering offers an exciting alternative in the search for living organ replacement structures. Several methodologies have emerged for constructing blood vessel replacements with biological functionality. Common strategies include cell-seeded biodegradable synthetic scaffolds, cell self-assembly, cell-seeded gels and xenogeneic acellular materials. A wide range of materials are being investigated as potential scaffolds for vascular tissue engineering applications. Some are commercialised and others are still in development. Recently, researchers have studied the role of fibrin gel as a three-dimensional scaffold in vascular tissue engineering. This overview describes the properties of fibrin gel in vascular tissue engineering and highlights some recent progress and difficulties encountered in the development of cell fibrin scaffold technology.
The Pseudomonas aeruginosa CreBC Two-Component System Plays a Major Role in the Response to β-Lactams, Fitness, Biofilm Growth, and Global Regulation

ABSTRACT Pseudomonas aeruginosa is a ubiquitous versatile environmental microorganism with a remarkable ability to grow under diverse environmental conditions. Moreover, P. aeruginosa is responsible for life-threatening infections in immunocompromised and cystic fibrosis patients, as the extraordinary capacity of this pathogen to develop antimicrobial resistance dramatically limits our therapeutic arsenal. Its large genome carries an outstanding number of genes belonging to regulatory systems, including multiple two-component sensor-regulator systems that modulate the response to the different environmental stimuli. Here, we show that one of two systems, designated CreBC (carbon source responsive) and BlrAB (β-lactam resistance), might be of particular relevance. We first identified the stimuli triggering the activation of the CreBC system, which specifically responds to penicillin-binding protein 4 (PBP4) inhibition by certain β-lactam antibiotics. Second, through an analysis of a large comprehensive collection of mutants, we demonstrate an intricate interconnection between the CreBC system, the peptidoglycan recycling pathway, and the expression of the concerning chromosomal β-lactamase AmpC. Third, we show that the CreBC system, and particularly its effector inner membrane protein CreD, plays a major role in bacterial fitness and biofilm development, especially in the presence of subinhibitory concentrations of β-lactams. Finally, global transcriptomics reveals broad regulatory functions of CreBC in basic physiological aspects, particularly anaerobic respiration, in both the presence and absence of antibiotics. Therefore, the CreBC system is envisaged as a potentially interesting target for improving the efficacy of β-lactams against P. aeruginosa infections.
NetSecRadar: A real-time visualization system for network security: VAST 2012 Mini Challenge. Award: Honorable mention for interesting use of radial visualization technique

NetSecRadar is a visual analytics system to aid in monitoring the network security in real time and perceiving the overall view of the security situation using radial graph. At present, we use this tool mainly for IDS alerts to analyze the irregular behavioral patterns, and synthesize interactions, filtering and drill-down to detect the potential intrusions. In conclusion, we describe how this system was used to analyze the mini-challenges of the 2012 VAST challenge.
Corporate governance and corporate finance practices in a Kuwait Stock Exchange market listed firm: a survey to confront theory with practice

Purpose – This paper aims to explore the issue of corporate governance mechanisms by including the importance of stakeholders, primary objectives of the firm and the ownership of top financial managers of listed firms in Kuwait in the survey tool. It attempts to investigate whether theory aligns with the behaviour of financial managers in practice in an emerging market case.Design/methodology/approach – A survey was developed to focus primarily on the current corporate finance practices implemented by CFOs in listed companies in Kuwait. The target respondents are listed firms in the Kuwaiti Stock Exchange (KSE). The survey includes questions on topics that are closely related to capital budgeting, capital structure, cost of capital and dividend policy. For example, the survey asks the managers how they estimate their cost of equity (CAPM or other methods) and whether the impact of the weighted average cost of equity is taken into consideration in their capital structure choices.Findings – A surprising num.
Numerical Analysis of Mode Discrimination by Intracavity Patterning in Long-Wavelength Wafer-Fused Vertical-Cavity Surface-Emitting Lasers

This paper presents an extensive numerical analysis of 1.3-μm wavelength wafer-fused vertical-cavity surface-emitting lasers (VCSELs) incorporating intracavity patterning. Using a 3-D, self-consistent model of the physical phenomena in VCSELs, supported by experimental results used for parameter calibration, we investigate the influence of arch-and ring-shaped intracavity features with a broad range of geometrical parameters on the modal behavior of the VCSEL. To design and optimize the devices, we used intracavity patterning that provides very strong discrimination of higher order modes, pushing them out from the active region. This mechanism makes possible single mode operation under a broad range of currents and could potentially enhance the single-mode output power of these devices.
Elevation of the glycated albumin to glycated hemoglobin ratio during the progression of hepatitis C virus related liver fibrosis.

AIM To analyze the relationship between the glycated albumin (GA) to glycated hemoglobin (HbA1c) ratio and the histological grading of liver fibrosis. METHODS The study retrospectively included consecutive hepatitis C virus positive chronic liver disease patients (n = 142) who had undergone percutaneous liver biopsy between January 2008 and March 2010 at our institution. The ratios of GA/HbA1c were calculated in all patients to investigate the relationship with the degree of the liver fibrosis. The values of the aspartate aminotransferase-to-platelet ratio index (APRI), an excellent marker for the evaluation of liver fibrosis, were also calculated. In addition, we combined the ratio of GA/HbA1c and the APRI in order to improve our ability to detect the presence of significant liver fibrosis. RESULTS Sixty-one (43%) patients had either no fibrosis or minimal fibrosis (METAVIR score: F0-F1), while 25 (17%) had intermediate fibrosis (F2). Fifty-six (39%) patients had severe fibrosis (F3-F4) and 27 of them had cirrhosis (F4). The mean values of the GA/HbA1c increased with the progression of the fibrosis (F0-1: 2.83 ± 0.24, F2: 2.85 ± 0.24, F3: 2.92 ± 0.35, F4: 3.14 ± 0.54). There was a significant difference between the F0-F1 vs F4, F2 vs F4, and F3 vs F4 groups (P < 0.01, P < 0.01, P < 0.01 and P < 0.05, respectively). The GA/HbA1c ratio was significantly higher in the patients with cirrhosis (F4) than in those without cirrhosis (F0-F3) (3.14 ± 0.54 vs 2.85 ± 0.28, P < 0.0001). The GA/HbA1c ratio was also significantly higher in the patients with severe fibrosis (F3-F4) than in those without severe liver fibrosis (F0-F2) (3.03 ± 0.41 vs 2.84 ± 0.24, P < 0.001). Furthermore, the GA/HbA1c ratio was also significantly higher in the patients with significant fibrosis (F2-F4) than in those without significant liver fibrosis (F0-F1) (2.98 ± 0.41 vs 2.83 ± 0.24, P < 0.001). The diagnostic performance of the increased GA/HbA1c ratio (> 3.0) was as follows: its sensitivity and specificity for the detection of liver cirrhosis (F4) were 59.3% and 70.4%, respectively and its sensitivity and specificity for the detection of severe liver fibrosis (F3-F4) were 50.0% and 74.4%, respectively. With regard to the detection of significant fibrosis (F2-F4), its sensitivity was 44.4% and its specificity was 77.0%. Although even the excellent marker APRI shows low sensitivity (25.9%) for distinguishing patients with or without significant fibrosis, the combination of the APRI and GA/HbA1c ratio increased the sensitivity up to 42.0%, with only a modest decrease in the specificity (from 90.2% to 83.6%). CONCLUSION The GA/HbA1c ratio increased in line with the histological severity of liver fibrosis, thus suggesting that this ratio is useful as a supportive index of liver fibrosis.
Demethylation of somatic and testis-specific histone H2A and H2B genes in F9 embryonal carcinoma cells

In contrast to many other genes containing a CpG island, the testis-specific H2B (TH2B) histone gene exhibits tissue-specific methylation patterns in correlation with gene activity. Characterization of the methylation patterns within a 20-kb segment containing the TH2A and TH2B genes in comparison with that in a somatic histone cluster revealed that: (i) the germ cell-specific unmethylated domain of the TH2A and TH2B genes is defined as a small region surrounding the CpG islands of the TH2A and TH2B genes and (ii) somatic histone genes are unmethylated in both liver and germ cells, like other genes containing CpG islands, whereas flanking sequences are methylated. Transfection of in vitro-methylated TH2B, somatic H2B, and mouse metallothionein I constructs into F9 embryonal carcinoma cells revealed that the CpG islands of the TH2A and TH2B genes were demethylated like those of the somatic H2A and H2B genes and the metallothionein I gene. The demethylation of those CpG islands became significantly inefficient at a high number of integrated copies and a high density of methylated CpG dinucleotides. In contrast, three sites in the somatic histone cluster, of which two sites are located in the long terminal repeat of an endogenous retrovirus-like sequence, were efficiently demethylated even at a high copy number and a high density of methylated CpG dinucleotides. These results suggest two possible mechanisms for demethylation in F9 cells and methylation of CpG islands of the TH2A and TH2B genes at the postblastula stage during embryogenesis.
Audit Firm Tenure and Fraudulent Financial Reporting

The Sarbanes‐Oxley Act (2002) required the U.S. Comptroller General to study the potential effects of requiring mandatory audit firm rotation. The General Accounting Office (GAO) concludes in its recently released study of mandatory audit firm rotation that “mandatory audit firm rotation may not be the most efficient way to strengthen auditor independence” (GAO 2003, Highlights). However, the GAO also suggests that mandatory audit firm rotation could be necessary if the Sarbanes‐Oxley Act's requirements do not lead to improved audit quality (GAO 2003, 5). We examine the relation between audit firm tenure and fraudulent financial reporting. Comparing firms cited for fraudulent reporting from 1990 through 2001 with both a matched set of non‐fraud firms and with the available population of non‐fraud firms, we find that fraudulent financial reporting is more likely to occur in the first three years of the auditor‐client relationship. We fail to find any evidence that fraudulent financial reporting is more lik.