Miracle-dz/UniFAR-FTUs huggingface dataset:
Perceived haze, stress, and negative emotions: An ecological momentary assessment study of the affective responses to haze

The aim of this study was to examine the mediating role of stress in the association between people’s perceived haze and negative emotions in daily life. Using ecological momentary assessment, 95 college students reported their perceived haze, stress, and negative emotions twice a day over the course of 2 weeks. The results showed a positive relationship between perceived haze and negative emotions. More importantly, this association was significantly mediated by levels of stress. Findings suggested that people who perceived more severe haze may report higher stress levels, which in turn may lead to increases in negative emotions.
Production and characterization of a monoclonal antibody that cross-reacts with the mycotoxins nivalenol and 4-deoxynivalenol

Nivalenol is a mycotoxin produced by certain fungi that are pathogenic to important cereal crops, in particular maize, wheat, and barley. This toxin, 3α,4β,7α,15-tetrahydroxy-12,13-epoxytrichothec-9-en-8-one, is found worldwide and is closely related to 4-deoxynivalenol (DON or vomitoxin), a mycotoxin associated with outbreaks of Fusarium head blight in North America. The literature on the toxicity of nivalenol suggests it is similar, if not more toxic, than DON. Despite the development of rapid immunologically based assays for detecting DON, such assays have not existed for detecting nivalenol without chemical modification of the analyte. This paper describes the development of a monoclonal antibody using a nivalenol–glycine protein conjugate. The monoclonal antibody was most specific for an acetylated form of DON (3-Ac-DON), but it exhibited sensitivity and cross-reactivity that were useful for detecting nivalenol and DON at relevant levels without the need to modify either toxin chemically. In an competitive indirect ELISA format, the concentrations of toxins able to inhibit colour development by 50% (IC50) were 1.7, 15.8, 27.5, 68.9, and 1740 ng ml−1 for the mycotoxins 3-Ac-DON, DON, nivalenol, 15-Ac-DON, and fusarenon-X, respectively. The antibody was also used to develop a competitive direct ELISA for DON and nivalenol, with IC50's of 16.5 ng ml−1 (DON) and 33.4 ng ml−1 (nivalenol). These assays are capable of detecting both DON and nivalenol simultaneously, a property that may be useful in regions where these toxins co-occur or in formats, such as immunoaffinity columns, where co-isolation of both toxins is desirable.
Investigating the Impacts of Distributed Generation on Transmission Expansion Cost: An Australian Case Study

Distributed generation (DG) is rapidly increasing its penetration level in Australia, and is expected to play a more important role in the power industry. An important benefit of DG is its ability to defer transmission investments. In this paper, a simulation model is implemented to conduct quantitative analysis on the effect of DG on transmission investment deferral. The transmission expansion model is formulated as a multi-objective optimization problem with comprehensive technical constraints, such as AC power flow and system security. The model is then applied to study the Queensland electricity market in Australia. Simulation results show that, DG does show the ability to reduce transmission investments. This ability however is greatly influenced by a number of factors, such as the locations of DG, the network topology, and the power system technical constraints.
Cerebral Blood Flow Modulation by Basal Forebrain or Whisker Stimulation Can Occur Independently of Large Cytosolic Ca2+ Signaling in Astrocytes

We report that a brief electrical stimulation of the nucleus basalis of Meynert (NBM), the primary source of cholinergic projection to the cerebral cortex, induces a biphasic cerebral cortical blood flow (CBF) response in the somatosensory cortex of C57BL/6J mice. This CBF response, measured by laser Doppler flowmetry, was attenuated by the muscarinic type acetylcholine receptor antagonist atropine, suggesting a possible involvement of astrocytes in this type of CBF modulation. However, we find that IP3R2 knockout mice, which lack cytosolic Ca2+ surges in astrocytes, show similar CBF changes. Moreover, whisker stimulation resulted in similar degrees of CBF increase in IP3R2 knockout mice and the background strain C57BL/6J. Our results show that neural activity-driven CBF modulation could occur without large cytosolic increases of Ca2+ in astrocytes.
Axon Guidance: Stretching Gradients to the Limit

Neuronal growth cones, the sensory-motile structures at the tips of developing axons, navigate to their targets over distances that can be many times greater than their diameter. They may accomplish this impressive task by following spatial gradients of axon guidance molecules in their environment (Bonhoeffer & Gierer, 1984; Tessier-Lavigne & Placzek, 1991; Baier & Bonhoeffer, 1994). We calculate the optimal shape of a gradient and the distance over which it can be detected by a growth cone for two competing mechanistic models of axon guidance. The results are surprisingly simple: Regardless of the mechanism, the maximum distance is about 1 cm. Since gradients and growth cones have coevolved, we suggest that the shape of the gradient in situ will predict the mechanism of gradient detection. In addition, we show that the experimentally determined dissociation constants for receptor-ligand complexes implicated in axon guidance are about optimal with respect to maximizing guidance distance. The relevance of these results to the retinotectal system is discussed.
Dynamical Consequences of Fast-Rising, Slow-Decaying Synapses in Neuronal Networks

Synapses that rise quickly but have long persistence are shown to have certain computational advantages. They have some unique mathematical properties as well and in some instances can make neurons behave as if they are weakly coupled oscillators. This property allows us to determine their synchronization properties. Furthermore, slowly decaying synapses allow recurrent networks to maintain excitation in the absence of inputs, whereas faster decaying synapses do not. There is an interaction between the synaptic strength and the persistence that allows recurrent networks to fire at low rates if the synapses are sufficiently slow. Waves and localized structures are constructed in spatially extended networks with slowly decaying synapses.
Semisupervised Discriminative Locally Enhanced Alignment for Hyperspectral Image Classification

This paper proposes a new semisupervised dimension reduction (DR) algorithm based on a discriminative locally enhanced alignment technique. The proposed DR method has two aims: to maximize the distance between different classes according to the separability of pairwise samples and, at the same time, to preserve the intrinsic geometric structure of the data by the use of both labeled and unlabeled samples. Furthermore, two key problems determining the performance of semisupervised methods are discussed in this paper. The first problem is the proper selection of the unlabeled sample set; the second problem is the accurate measurement of the similarity between samples. In this paper, multilevel segmentation results are employed to solve these problems. Experiments with extensive hyperspectral image data sets showed that the proposed algorithm is notably superior to other state-of-the-art dimensionality reduction methods for hyperspectral image classification.
MDM2 and CDK4 Immunostainings Are Useful Adjuncts in Diagnosing Well-Differentiated and Dedifferentiated Liposarcoma Subtypes: A Comparative Analysis of 559 Soft Tissue Neoplasms With Genetic Data

Atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) may be difficult to distinguish from benign adipose tumors and from poorly differentiated sarcomas, respectively. Genetically, they are characterized by amplification of MDM2 and CDK4 genes on chromosome 12q13-15. We examined a series of 559 soft tissue tumors (44 ALT-WDLPS, 61 DDLPS, 49 benign adipose tumors, and 405 non-ALT-WDLPS/DDLPS sarcomas) for MDM2 and CDK4 expression using immunohistochemistry. MDM2 and CDK4 immunoexpressions were compared with gene amplification status (as assessed by quantitative PCR and/or comparative genomic hybridization) in 241 neoplasms. Most ALT-WDLPS/DDLPS expressed MDM2 (97%) and CDK4 (92%) as opposed to few benign adipose tumors (MDM2, 5%; CDK4, 2%) and a limited number of non-ALT-WDLSP/DDLPS sarcomas (MDM2, 19%; CDK4, 6%). The sensitivity and specificity of MDM2 and CDK4 immunostainings in identifying ALT-WDLPS/DDLPS among other soft tissue tumors were 97% and 92%, and 83% and 95%, respectively. MDM2 and CDK4 immunostainings were particularly useful to separate ALT-WDLPS from the large group of differentiated adipose tumors, and to distinguish DDLPS from poorly differentiated sarcomas. A strong correlation was observed between MDM2 and CDK4 stainings and gene amplification status. In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas.
Model-Based Acceleration of Look-Locker T1 Mapping

Mapping the longitudinal relaxation time T 1 has widespread applications in clinical MRI as it promises a quantitative comparison of tissue properties across subjects and scanners. Due to the long scan times of conventional methods, however, the use of quantitative MRI in clinical routine is still very limited. In this work, an acceleration of Inversion-Recovery Look-Locker (IR-LL) T 1 mapping is presented. A model-based algorithm is used to iteratively enforce an exponential relaxation model to a highly undersampled radially acquired IR-LL dataset obtained after the application of a single global inversion pulse. Using the proposed technique, a T 1 map of a single slice with 1.6mm in-plane resolution and 4mm slice thickness can be reconstructed from data acquired in only 6s. A time-consuming segmented IR experiment was used as gold standard for T 1 mapping in this work. In the subsequent validation study, the model-based reconstruction of a single-inversion IR-LL dataset exhibited a T 1 difference of less than 2.6% compared to the segmented IR-LL reference in a phantom consisting of vials with T 1 values between 200ms and 3000ms. In vivo, the T 1 difference was smaller than 5.5% in WM and GM of seven healthy volunteers. Additionally, the T 1 values are comparable to standard literature values. Despite the high acceleration, all model-based reconstructions were of a visual quality comparable to fully sampled references. Finally, the reproducibility of the T 1 mapping method was demonstrated in repeated acquisitions. In conclusion, the presented approach represents a promising way for fast and accurate T 1 mapping using radial IR-LL acquisitions without the need of any segmentation.
The Radial Artery in Reoperative Coronary Bypass Surgery:

Abstract Background: Failure of saphenous vein grafts (SVG) is a significant cause for coronary reoperation (redo CABG). The radial artery (RA) because of its availability, and versatility is well suited to use (together with internal thoracic arteries (ITA) in redo CABG, especially to replace failed SVG. We evaluated our experience where the RA was a major conduit in redo CABG over the past 5 years. Methods: From July 1996 to June 2002, 590 consecutive patients underwent redo CABG where one or both RA(s) were used, together with LITA or RITA. The mean age was 67.3 years, 82% were male, and 19% diabetic, 419 (71%) had Class III or IV angina, 135 (23%) had left main stenosis, and 210 (36%) had an LVEF < 0.50. There were a total of 877 RA conduits (303 single, 287 bilateral), 518 new LITA or RITA. A mean of 2.8 new distal anastomoses constructed 92% (2.6 per patient)of the arterial grafts. Follow‐up was at 1 month, 3 months, and then yearly. The results were compared with 6466 primary CABG performed in the same time frame, and with a prior cohort of 741 consecutive patients having redo CABG without an RA in which identical operative techniques had otherwise been used. Results: The 30‐day mortality was 3.9% (23 patients). Morbidity was low. Perioperative myocardial infarction occurred in 16 (2.7%) patients, stroke in 10 (1.7%), sternal infection in 10 (1.7%), donor site infection in 2 (0.3%), and IABP use in 23 patients (3.9%)—including 10 preoperatively. The results were better when compared to a prior cohort of 741 patients with redo CABG (1991 to 1996) without use of the RA. The results were inferior to that of the contemporary primary CABG. Operative mortality was 3.9% versus 0.9%, p = 0.002, myocardial infarction 2.7% versus 0.8%, p = 0.03. Conclusion: The use of the RA (together with ITA) in redo CABG achieved total arterial revascularization in 92% of cases and is associated with excellent results, at least equal to or superior to those achieved previously.
Reviewing Data Visualization: an Analytical Taxonomical Study

This paper presents an analytical taxonomy that can suitably describe, rather than simply classify, techniques for data presentation. Unlike previous works, we do not consider particular aspects of visualization techniques, but their mechanisms and foundational vision perception. Instead of just adjusting visualization research to a classification system, our aim is to better understand its process. For doing so, we depart from elementary concepts to reach a model that can describe how visualization techniques work and how they convey meaning
Clinical efficacy of computerised cognitive-behavioural therapy for anxiety and depression in primary care: Randomised controlled trial

Background Preliminary results have demonstrated the clinical efficacy of computerised cognitive-behavioural therapy (CBT) in the treatment of anxiety and depression in primary care. Aims To determine, in an expanded sample, the dependence of the efficacy of this therapy upon clinical and demographic variables. Method A sample of 274 patients with anxiety and/or depression were randomly allocated to receive, with or without medication, computerised CBTor treatment as usual, with follow-up assessment at 6 months. Results The computerised therapy improved depression, negative attributional style, work and social adjustment, without interaction with drug treatment, duration of preexisting illness or severity of existing illness. For anxiety and positive attributional style, treatment interacted with severity such that computerised therapy did better than usual treatment for more disturbed patients. Computerised therapy also led to greater satisfaction with treatment. Conclusions Computer-delivered CBT is a widely applicable treatment for anxiety and/or depression in general practice.
Retrospective analysis of opioid medication incidents requiring administration of naloxone.

BACKGROUND Opioid analgesics are high-alert medications known to cause adverse drug events. OBJECTIVES The purpose of this study was to determine the cause of opioid incidents requiring administration of naloxone, an opioid reversal agent. The specific objectives were to determine the number of opioid incidents and the proportion of incidents documented through occurrence reporting and to characterize the incidents by phase in the medication-use process, by type of incident, and by drug responsible for toxic effects. METHODS A retrospective chart analysis was conducted using records from 2 acute care centres in the Regina Qu'Appelle Health Region. The study included inpatients who received naloxone for reversal of opioid toxicity resulting from licit, in-hospital opioid use. Cases were classified as preventable or nonpreventable. Preventable cases were analyzed to determine the phase of the medication-use process during which the incident occurred. These cases were also grouped thematically by the type of incident. The drug most likely responsible for opioid toxicity was determined for each case. The proportion of cases documented by occurrence reporting was also noted. RESULTS Thirty-six cases involving administration of naloxone were identified, of which 29 (81%) were deemed preventable. Of these 29 preventable cases, the primary medication incident occurred most frequently in the prescribing phase (23 [79%]), but multiple phases were often involved. The cases were grouped into 6 themes according to the type of incident. Morphine was the drug that most frequently resulted in toxic effects (18 cases [50%]). Only two of the cases (5.6%) were documented by occurrence reports. CONCLUSION Preventable opioid incidents occurred in the acute care centres under study. A combination of medication safety initiatives involving multiple disciplines may be required to decrease the incidence of these events and to better document their occurrence.
Singular solutions of a nonlinear elliptic equation in a punctured domain

We consider the following semilinear problem  −∆u(x) = a(x)uσ(x), x ∈ Ω\{0} (in the distributional sense), u > 0, in Ω\{0}, lim |x|→0 |x|n−2 u(x) = 0, u(x) = 0, x ∈ ∂Ω, where σ < 1, Ω is a bounded regular domain in Rn (n ≥ 3) containing 0 and a is a positive continuous function in Ω\{0}, which may be singular at x = 0 and/or at the boundary ∂Ω. When the weight function a(x) satisfies suitable assumption related to Karamata class, we prove the existence of a positive continuous solution on Ω\{0}, which could blow-up at the origin. The global asymptotic behavior of this solution is also obtained.
Collective cell durotaxis emerges from long-range intercellular force transmission

The ability of cells to follow gradients of extracellular matrix stiffness—durotaxis—has been implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that exhibited durotaxis even if isolated constituent cells did not. This emergent mode of directed collective cell migration applied to a variety of epithelial cell types, required the action of myosin motors, and originated from supracellular transmission of contractile physical forces. To explain the observed phenomenology, we developed a generalized clutch model in which local stick-slip dynamics of cell-matrix adhesions was integrated to the tissue level through cell-cell junctions. Collective durotaxis is far more efficient than single-cell durotaxis; it thus emerges as a robust mechanism to direct cell migration during development, wound healing, and collective cancer cell invasion.
TussleOS: managing privacy versus functionality trade-offs on IoT devices

Networked sensors and actuators are increasingly permeating our computing devices, and provide a variety of functions for Internet of Things (IoT) devices and applications. However, this sensor data can also be used by applications to extract private information about users. Applications and users are thus in a tussle over access to private data. Tussles occur in operating systems when stakeholders with competing interests try to access shared resources such as sensor data, CPU time, or network bandwidth. Unfortunately, existing operating systems lack a principled approach for identifying, tracking, and resolving such tussles. Moreover, users typically have little control over how tussles are resolved. Controls for sensor data tussles, for example, often fail to address trade-offs between functionality and privacy. Therefore, we propose a framework to explicitly recognize and manage tussles. Using sensor data as an example resource, we investigate the design of mechanisms for detecting and resolving privacy tussles in a cyber-physical system, enabling privacy and functionality to be negotiated between users and applications. In doing so, we identify shortcomings of existing research and present directions for future work.
Impact of inspiratory muscle training in patients with COPD: what is the evidence?

A meta-analysis including 32 randomised controlled trials on the effects of inspiratory muscle training (IMT) in chronic obstructive pulmonary disease (COPD) patients was performed. Overall and subgroup analyses with respect to training modality (strength or endurance training, added to general exercise training) and patient characteristics were performed. Significant improvements were found in maximal inspiratory muscle strength (PI,max; +13 cmH2O), endurance time (+261 s), 6- or 12-min walking distance (+32 and +85 m respectively) and quality of life (+3.8 units). Dyspnoea was significantly reduced (Borg score -0.9 point; Transitional Dyspnoea Index +2.8 units). Endurance exercise capacity tended to improve, while no effects on maximal exercise capacity were found. Respiratory muscle endurance training revealed no significant effect on PI,max, functional exercise capacity and dyspnoea. IMT added to a general exercise programme improved PI,max significantly, while functional exercise capacity tended to increase in patients with inspiratory muscle weakness (PI,max <60 cmH2O). IMT improves inspiratory muscle strength and endurance, functional exercise capacity, dyspnoea and quality of life. Inspiratory muscle endurance training was shown to be less effective than respiratory muscle strength training. In patients with inspiratory muscle weakness, the addition of IMT to a general exercise training program improved PI,max and tended to improve exercise performance.
Clarifying confusion: the confusion assessment method. A new method for detection of delirium.

OBJECTIVE To develop and validate a new standardized confusion assessment method (CAM) that enables nonpsychiatric clinicians to detect delirium quickly in high-risk settings. DESIGN Prospective validation study. SETTING Conducted in general medicine wards and in an outpatient geriatric assessment center at Yale University (site 1) and in general medicine wards at the University of Chicago (site 2). PATIENTS The study included 56 subjects, ranging in age from 65 to 98 years. At site 1, 10 patients with and 20 without delirium participated; at site 2, 16 patients with and 10 without delirium participated. MEASUREMENTS AND MAIN RESULTS An expert panel developed the CAM through a consensus building process. The CAM instrument, which can be completed in less than 5 minutes, consists of nine operationalized criteria from the Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R). An a priori hypothesis was established for the diagnostic value of four criteria: acute onset and fluctuating course, inattention, disorganized thinking, and altered level of consciousness. The CAM algorithm for diagnosis of delirium required the presence of both the first and the second criteria and of either the third or the fourth criterion. At both sites, the diagnoses made by the CAM were concurrently validated against the diagnoses made by psychiatrists. At sites 1 and 2 values for sensitivity were 100% and 94%, respectively; values for specificity were 95% and 90%; values for positive predictive accuracy were 91% and 94%; and values for negative predictive accuracy were 100% and 90%. The CAM algorithm had the highest predictive accuracy for all possible combinations of the nine features of delirium. The CAM was shown to have convergent agreement with four other mental status tests, including the Mini-Mental State Examination. The interobserver reliability of the CAM was high (kappa = 0.81 - 1.0). CONCLUSIONS The CAM is sensitive, specific, reliable, and easy to use for identification of delirium.