Miracle-dz/UniFAR-FTUs huggingface dataset:
Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung

Differentiation and recruitment of alternatively activated macrophages (AAMacs) are hallmarks of several inflammatory conditions associated with infection, allergy, diabetes, and cancer. AAMacs are defined by the expression of Arginase 1, chitinase-like molecules, and resistin-like molecule (RELM) α/FIZZ1; however, the influence of these molecules on the development, progression, or resolution of inflammatory diseases is unknown. We describe the generation of RELM-α–deficient (Retnla−/−) mice and use a model of T helper type 2 (Th2) cytokine-dependent lung inflammation to identify an immunoregulatory role for RELM-α. After challenge with Schistosoma mansoni (Sm) eggs, Retnla−/− mice developed exacerbated lung inflammation compared with their wild-type counterparts, characterized by excessive pulmonary vascularization, increased size of egg-induced granulomas, and elevated fibrosis. Associated with increased disease severity, Sm egg–challenged Retnla−/− mice exhibited elevated expression of pathogen-specific CD4+ T cell–derived Th2 cytokines. Consistent with immunoregulatory properties, recombinant RELM-α could bind to macrophages and effector CD4+ Th2 cells and inhibited Th2 cytokine production in a Bruton's tyrosine kinase–dependent manner. Additionally, Retnla−/− AAMacs promoted exaggerated antigen-specific Th2 cell differentiation. Collectively, these data identify a previously unrecognized role for AAMac-derived RELM-α in limiting the pathogenesis of Th2 cytokine-mediated pulmonary inflammation, in part through the regulation of CD4+ T cell responses.
Inhaled Corticosteroids Increase the Risk of Pneumonia in Patients With Chronic Obstructive Pulmonary Disease

Abstract The association of inhaled corticosteroids (ICS) and pneumonia in patients with chronic obstructive pulmonary disease (COPD) is still controversial. From the National Health Insurance Database of Taiwan, COPD cases with history of acute exacerbation (AE) were identified (COPD cohort). Time-dependent Cox regression analysis was applied to investigate the risk factors for pneumonia with COPD severity controlled by surrogate variables. Among the COPD cohort, those who continuously used ICS for more than 360 days without interruption were selected (ICS cohort). The incidence rate of pneumonia during ICS use was compared with those before ICS use and after ICS discontinuation by using pair t test. A total of 6034 and 842 cases were identified as the COPD and ICS cohorts, respectively. In the COPD cohort, recent ICS use was independently associated with pneumonia (hazard ratio: 1.06 [1.02–1.11] for per 80 mg of budesonide). Other independent risk factors included age, male, diabetes mellitus, malignancy, low income, baseline pneumonia event, and recent use of oral corticosteroids and aminophylline. In the ICS cohort, while AE rate gradually decreased, the incidence rate of pneumonia significantly increased after ICS use (from 0.10 to 0.21 event/person-year, P = 0.001). This study demonstrates the association between ICS use and pneumonia in patients with COPD and history of AE. ICS should be judiciously used in indicated COPD patients.
MMP9 Rs3918242 Polymorphism Affects Tachycardia-Induced MMP9 Expression in Cultured Atrial-Derived Myocytes but Is Not a Risk Factor for Atrial Fibrillation among the Taiwanese

Matrix metalloproteinase (MMP) plays an important role in the pathogenesis of atrial fibrillation (AF). The MMP9 promoter has a functional polymorphism rs3918242 that can regulate the level of gene transcription. This study recruited 200 AF patients and 240 controls. The MMP9 rs3918242 was examined by polymerase chain reactions. HL-1 atrial myocytes were cultured and electrically stimulated. Right atrial appendages were obtained from six patients with AF and three controls with sinus rhythm undergoing open heart surgery. The MMP9 expression and activity were determined using immunohistochemical analysis and gelatin zymography, respectively. Rapid pacing induces MMP9 secretion from HL-1 myocytes in a time- and dose-dependent manner. The responsiveness of MMP9 transcriptional activity to tachypacing was significantly enhanced by rs3918242. The expression of MMP9 was increased in fibrillating atrial tissue than in sinus rhythm. However, the distribution of rs3918242 genotypes and allele frequencies did not significantly differ between the control and AF groups. HL-1 myocyte may secrete MMP9 in response to rapid pacing, and the secretion could be modulated by rs3918242. Although the MMP9 expression of human atrial myocyte is associated with AF, our study did not support the association of susceptibility to AF among Taiwanese subjects with the MMP9 rs3918242 polymorphism.
Mobilization of CD34+-Progenitor Cells in Patients with Severe Trauma

Circulating CD34+ progenitor cells () gained importance in the field of regenerative medicine due to their potential to home in on injury sites and differentiate into cells of both endothelial and osteogenic lineages. In this study, we analyzed the mobilization kinetics and the numbers of CD34+, CD31+, CD45+, and CD133+ cells in twenty polytrauma patients (n = 13 male, n = 7 female, mean age 46.5±17.2 years, mean injury severity score (ISS) 35.8±12.5 points). In addition, the endothelial differentiation capacity of enriched CD34+cells was assessed by analyzing DiI-ac-LDL/lectin uptake, the expression of endothelial markers, and the morphological characteristics of these cells in Matrigel and spheroid cultures. We found that on days 1, 3, and 7 after a major trauma, the number of CD34+cells increased from 6- up to 12-fold (p<0.0001) over the number of CD34+cells from a control population of healthy, age-matched volunteers. The numbers of CD31+ cells were consistently higher on days 1 (1.4-fold, p<0.01) and 7 (1.3-fold, p<0.01), whereas the numbers of CD133+ cell did not change during the time course of investigation. Expression of endothelial marker molecules in CD34+cells was significantly induced in the polytrauma patients. In addition, we show that the CD34+ cell levels in severely injured patients were not correlated with clinical parameters, such as the ISS score, the acute physiology and chronic health evaluation II score (APACHE II), as well as the sequential organ failure assessment score (SOFA-2). Our results clearly indicate that pro-angiogenic cells are systemically mobilized after polytrauma and that their numbers are sufficient for the development of novel therapeutic models in regenerative medicine.
A rotating adaptive model for human tracking in Thermal Catadioptric Omnidirectional Vision

Previously, most human tracking system mainly focuses on conventional imaging system that depends on the illumination and has a limited field of view. In this paper, we propose to introduce a novel surveillance system that is Thermal Catadioptric Omnidirectional (TCO) Vision System. The proposed system is able to realize the surveillance in all-weather and big field of view conditions. For human tracking in TCO vision, the most of existing contour based feature cannot be used directly unless unwarp the distorted omnidirectional image into the traditional rectangle panoramic image for rectification. In this paper, a contour coding based rotating adaptive model is proposed, which is developed based on the characteristic of TCO vision. The proposed model not requires unwarping but only use relative angle based on location of target in the omnidirectional image to change the sequence of sampling from the proposed model. Based on this model, contour feature is extracted, which contains geometric location (r, θ) and gradient information g(r, θ) of the target. The extracted feature is fed into Support Vector Machine (SVM) for classification. For tracking purpose, we integrate the obtained classification posterior probability of SVM with the likelihood observation of particle filter to realize tracking in TCO vision. Finally, a series comparative experiments and quantitative analysis are presented to verify the feasibility and performance of proposed tracking method.
Chronicle: Capture and Analysis of NFS Workloads at Line Rate

Insights from workloads have been instrumental in hardware and software design, problem diagnosis, and performance optimization. The recent emergence of software-defined data centers and application-centric computing has further increased the interest in studying workloads. Despite the ever-increasing interest, the lack of general frameworks for trace capture and workload analysis at line rate has impeded characterizing many storage workloads and systems. This is in part due to complexities associated with engineering a solution that is tailored enough to use computational resources efficiently yet is general enough to handle different types of analyses or workloads. This paper presents Chronicle, a high-throughput framework for capturing and analyzing Network File System (NFS) workloads at line rate. More specifically, we designed Chronicle to characterize NFS network traffic at rates above 10Gb/s for days to weeks. By leveraging the actor programming model and a pluggable, pipelined architecture, Chronicle facilitates a highly portable and scalable framework that imposes little burden on application programmers. In this paper, we demonstrate that Chronicle can reconstruct, process, and record storage-level semantics at the rate of 14Gb/s using general-purpose CPUs, disks, and NICs.
Validation of Adjustable Autonomous Control Systems for Production Plants

This paper describes a hybrid simulation environment, interfaced to an adjustable autonomous oftware architecture, for validation and evaluation of advanced designs using dynamic nteractive scenarios. The simulator provides upport for "real-time" evaluation of adjustable autonomy strategies. In such evaluations, control actions by the operator interact with hardware vents, including device failures, in the simulation and with the control actions of the adjustable autonomy software. The paper describes an application of the simulator for validation of advanced control software for gas transfer between chambers during a 90-day manned test of technology for Lunar-Mars life support.
Defocusing digital particle image velocimetry and the three-dimensional characterization of two-phase flows

Defocusing digital particle image velocimetry (DDPIV) is the natural extension of planar PIV techniques to the third spatial dimension. In this paper we give details of the defocusing optical concept by which scalar and vector information can be retrieved within large volumes. The optical model and computational procedures are presented with the specific purpose of mapping the number density, the size distribution, the associated local void fraction and the velocity of bubbles or particles in two-phase flows. Every particle or bubble is characterized in terms of size and of spatial coordinates, used to compute a true three-component velocity field by spatial three-dimensional cross-correlation. The spatial resolution and uncertainty limits are established through numerical simulations. The performance of the DDPIV technique is established in terms of number density and void fraction. Finally, the velocity evaluation methodology, using the spatial cross-correlation technique, is described and discussed in terms of velocity accuracy.
Bilateral interactions during contractions of intrinsic hand muscles.

During demanding voluntary contractions (e.g., high force or fatigue), activation is not restricted to the target muscle but extends to other ipsilateral muscles; even contralateral muscles become activated. The contralateral "irradiation" of activity was measured in five subjects during submaximal and maximal voluntary contractions (MVCs) of the first dorsal interosseous (FDI) (index finger abduction) and during unfatigued and fatigued conditions. All subjects were tested five times with at least one week between tests. Unilateral MVCs were associated with a substantial amount of contralateral FDI activation [mean = 7.9 +/- 6.7% (SD) MVC prior to fatigue]. The amount of such contralateral irradiation was significantly different between different individuals and was positively correlated between dominant and nondominant hands. During fatigue tests, the contractile activity of the contralateral "nontarget" index finger showed progressive increase (force, electromyogram) as was measured during both the submaximal task and interspersed MVCs of the target finger. In addition, a superimposed saw-tooth pattern of intermittently waxing and waning contractions commonly appeared contralaterally. The expression of contralateral irradiation force was itself fatigue-sensitive: less irradiation was seen in a recently fatigued muscle than was seen before the fatigue test. These fatigue effects could not be explained as having been caused by changes in muscle properties. Possible anatomical sites of contralateral irradiation are briefly discussed.
Prevention of acute rejection with antithymocyte globulin, avoiding corticosteroids, and delaying cyclosporin after renal transplantation.

BACKGROUND Despite their well-known side-effects, corticosteroids (Cs) are currently used after kidney transplantation. Avoidance of Cs may improve patient quality of life and eventual long-term survival. We report on a regimen using antithymocyte globulin (ATG) and mycophenolate mofetil (MMF) for induction, and cyclosporin (CsA) plus MMF for maintenance treatment of recipients of primary kidney transplantation. METHODS We studied 11 consecutive, non-sensitized renal transplant patients (nine cadaver and two living donors). Initial immunosuppression consisted of ATG (1.5 mg/kg/day, i.v.) given for 10 days and MMF (1.0 g/b.i.d.). CsA (8 mg/kg, in two divided doses) was started on post-operative day 11. Cs were only allowed in the case of MMF discontinuation, for the treatment of acute rejection, and in the event of recurrence of the primary glomerulonephritis. RESULTS All patients completed the entire 10-day ATG course. Main side-effects included fever (>38 degrees C) and serum sickness, observed in 73 and 27% of the patients respectively. The incidence of acute rejection was 27% (three of 11 patients). In two patients with acute rejection, serum sickness was concomitantly diagnosed and renal histology was partially compatible with immune-complex disease. The remaining patient had two episodes of low-grade rejection. All rejection episodes were rapidly reversed. Two patients (18%) were treated with ganciclovir for cytomegalovirus (CMV) infection. Two patients (18%) are currently receiving Cs for recurrence of the native glomerulonephritis and two rejection episodes respectively. All patients are currently alive with functioning kidneys (average follow-up of 8.4 months; average creatinine level of 128 micromol/l). CONCLUSION This pilot study suggests that ATG induction in combination with MMF and delayed introduction of CsA, in the absence of Cs, is not well tolerated in recipients of kidney transplants. An earlier introduction of calcineurin inhibitors and/or a shorter course of ATG may reduce the incidence of fever and serum sickness secondary to ATG.
Gene Signatures of Progression and Metastasis in Renal Cell Cancer

Purpose: To address the progression, metastasis, and clinical heterogeneity of renal cell cancer (RCC). Experimental Design: Transcriptional profiling with oligonucleotide microarrays (22,283 genes) was done on 49 RCC tumors, 20 non-RCC renal tumors, and 23 normal kidney samples. Samples were clustered based on gene expression profiles and specific gene sets for each renal tumor type were identified. Gene expression was correlated to disease progression and a metastasis gene signature was derived. Results: Gene signatures were identified for each tumor type with 100% accuracy. Differentially expressed genes during early tumor formation and tumor progression to metastatic RCC were found. Subsets of these genes code for secreted proteins and membrane receptors and are both potential therapeutic or diagnostic targets. A gene pattern (“metastatic signature”) derived from primary tumor was very accurate in classifying tumors with and without metastases at the time of surgery. A previously described “global” metastatic signature derived by another group from various non-RCC tumors was validated in RCC. Conclusion: Unlike previous studies, we describe highly accurate and externally validated gene signatures for RCC subtypes and other renal tumors. Interestingly, the gene expression of primary tumors provides us information about the metastatic status in the respective patients and has the potential, if prospectively validated, to enrich the armamentarium of diagnostic tests in RCC. We validated in RCC, for the first time, a previously described metastatic signature and further showed the feasibility of applying a gene signature across different microarray platforms. Transcriptional profiling allows a better appreciation of the molecular and clinical heterogeneity in RCC.
Single-Cell Elastography: Probing for Disease with the Atomic Force Microscope

The atomic force microscope (AFM) is emerging as a powerful tool in cell biology. Originally developed for high-resolution imaging purposes, the AFM also has unique capabilities as a nano-indenter to probe the dynamic viscoelastic material properties of living cells in culture. In particular, AFM elastography combines imaging and indentation modalities to map the spatial distribution of cell mechanical properties, which in turn reflect the structure and function of the underlying cytoskeleton. Such measurements have contributed to our understanding of cell mechanics and cell biology and appear to be sensitive to the presence of disease in individual cells. This chapter provides a background on the principles and practice of AFM elastography and reviews the literature comparing cell mechanics in normal and diseased states, making a case for the use of such measurements as disease markers. Emphasis is placed on the need for more comprehensive and detailed quantification of cell biomechanical properties beyond the current standard methods of analysis. A number of technical and practical hurdles have yet to be overcome before the method can be of clinical use. However, the future holds great promise for AFM elastography of living cells to provide novel biomechanical markers that will enhance the detection, diagnosis, and treatment of disease.
Literacy, Skills, and Welfare: Effects of Participation in Adult Literacy Programs

This paper examines the effect of adult literacy program participation on household consumption in Ghana. The adult literacy programs in Ghana are of special interest because they are more comprehensive than standard literacy programs and incorporate many additional topics. We use community fixed effects combined with instrumental variables to account for possible endogenous program placement and self-selection into program participation. For households where none of the adults have completed any formal education we find a substantial, positive, and statistically significant effect on household consumption. Our preferred estimate of the effect of participation for households without education is equivalent to a 10% increase in consumption per adult equivalent. The effects of participation on welfare for other households are smaller, not statistically significant, and become smaller the more educated the household is. We find positive and statistically significant effects of participation on literacy and numeracy rates, although the increases are too small to be the only explanation for the welfare effects. There is also evidence that participants are more likely to engage in market activities and to sell a variety of agricultural goods. Taking account of both direct cost and opportunity cost, we argue that the social returns of adult literacy programs are substantial.
Multilevel image segmentation using hybrid Darwinian swarm Optimization

DPSO-FOHA I and DPSO-FOHA II algorithms, based on multilevel thresholding are proposed in this paper. Optimal multilevel thresholds for colored images are maximized by using Otsu's between class variance functions. The Darwinian principle has been used to improve the value of fitness function along with the concept of fractional calculus, which optimizes it in lesser number of search iterations. Comparative analysis is presented between existing and proposed algorithms for performance assessment using standard deviation, PSNR, SSIM and computational search time of CPU. Experimental results depict that DPSO-FOHA II outperforms DPSO-FOHA I and another state of art methods in terms of PSNR, SSIM, fitness function and computational time.
Social Inequalities and International Trade

In this paper we study the role of social inequalities in development of international trade using the generalized gravity model. Many previous empirical studies, that explored the determinants of trade flows, concentrated only on traditional gravity variables such as the size of trading partners, factor abundance, technology differences or distance. In our study, in addition to the standard set of gravity variables we examine the role of aggregate social development indicators such as HDI, HPI, GDI, as well as detailed measures reflecting various forms of social inequalities. Our results show that measures of social inequalities significantly affect the volume of international trade flows.
Letter-level shape description by skeletonization in faded documents

We present a method for determining the skeletal shape description for letters in texts faded due to ageing and/or poor ink quality. The proposed algorithm is interesting in that it neither involves assumptions about demarcation of object regions from the background, nor does it require pixel connectivity in the text regions. Consequently, it may be applied for obtaining the shape descriptions of "sparse" regions, which are characteristic of letters in faded documents. Given the pixel distribution for a letter or a word from a faded document, the method involves an iterative evolution of a piecewise-linear approximation of the principal curve of this pixel distribution. By constraining the principal curve to lie on the edges of the Delaunay triangulation of the shape distribution, the adjacency relationships between regions in the shape can be detected and used in evolving the skeleton. The approximation of the principal curve, on convergence, gives the final skeletal shape. The skeletonization is invariant to Euclidean transformations and is adaptive in terms of the topology of the underlying shape distribution as well as in the number of units needed for the piece-wise approximation of the principal curve.
A Survey of Technologies for Climbing Robots Adhesion to Surfaces

Climbing robots are being developed for applications ranging from cleaning to inspection of difficult to reach constructions. These machines should be capable of travelling on different types of surfaces (such as floors, walls, ceilings) and to walk between such surfaces. Furthermore, these machines should adapt and reconfigure for various environment conditions and should be self-contained. Regarding the adhesion to the surface, they should be able to produce a secure gripping force using a light-weight mechanism. Bearing these facts in mind, this paper presents a survey of different technologies used for climbing robots adhesion to surfaces.