Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of acute renal failure on the pharmacokinetics of DA‐7867, a new oxazolidinone, in rats

The pharmacokinetic parameters of DA‐7867 were compared after intravenous and oral administration at a dose of 10 mg/kg to control rats and rats with acute renal failure induced by uranyl nitrate (rats with U‐ARF). After intravenous administration in rats with U‐ARF, the time‐averaged total body clearance (Cl) was significantly faster (2.45 versus 0.932 ml/min/kg) than controls due to significantly faster nonrenal clearance (2.25 versus 0.855 ml/min/kg) in rats with U‐ARF. The faster nonrenal clearance could be due to significantly greater gastrointestinal (including biliary) excretion; the amount of unchanged DA‐7867 recovered from the entire gastrointestinal tract at 24 h was significantly greater (30.3% versus 9.38% of intravenous dose) in rats with U‐ARF. In rats with U‐ARF, the Vss was significantly larger (1420 ml/kg compared with 580 ml/kg), but this was not due to a difference in plasma protein binding; the values were comparable between the two groups of rats. After oral administration to rats with U‐ARF, the total area under the plasma concentration‐time from time zero to time infinity (AUC) of DA‐7867 was significantly smaller than the controls (2560 µg min/ml versus 7440 µg min/ml), and this was not due mainly to a decrease in absorption from the gastrointestinal tract in rats with U‐ARF. Copyright © 2005 John Wiley & Sons, Ltd.
Audiovestibular Factors Influencing Quality of Life in Patients With Conservatively Managed Sporadic Vestibular Schwannoma

Objectives: To measure the health-related quality of life (QoL) of patients undergoing conservative management of a vestibular schwannoma and to identify audiovestibular factors that influence health-related QoL. Study Design: Cross-sectional case-control study. Intervention: Adult patients undergoing conservative management of a sporadic vestibular schwannoma were identified from a prospectively updated database. Each patient was asked to complete a series of questionnaires, including the Short Form 36 health-related QoL instrument, the Hearing Handicap Inventory, the Tinnitus Handicap Inventory, and the Dizziness Handicap Inventory. The QoL data obtained were compared with UK normal data. Multiple linear regression was performed to identify audiovestibular factors influencing QoL. Patients: Of 241 patients still undergoing conservative management, 165 completed the questionnaires. The mean age was 66.6 years. Mean duration of follow-up was 5.7 years. Results: Physical component summary scores were significantly lower than those of the normal population. Mental component summary scores were significantly above the normal population. Regression analysis showed that dizziness handicap score and age were strong predictors of physical component summary (both p < 0.0001). Dizziness handicap score and tinnitus handicap score were significant predictors of mental component summary (p = 0.0004 and p = 0.027 respectively). However, the model only explained a small amount of the data, suggesting that there may be other factors influencing QoL. Conclusion: Dizziness is the most significant audiovestibular predictor of QoL in patients with vestibular schwannomas. Tinnitus also has an impact on mental QoL. Hearing loss does not seem to influence QoL. Other factors such as illness perception may have an important role to play in determining QoL.
Toward real-time extraction of pedestrian contexts with stereo camera

We extract the mood of disquiet on street corners in real-time with stereo video camera systems. Last year we proposed a novel stereo measurement algorithm to detect moving people, which was focusing on moving region in video data. In this paper, we report our prototype of probabilistic inference engine that can detect contexts of individual pedestrian and groups of pedestrians. We demonstrated that the real-time extraction of higher-level pedestrian contexts using the Bayesian network model was effective for extracting several pedestrianspsila context.
Timing Jitter Characterization for Mixed-Signal Production Test Using the Interpolation Algorithm

In this paper, a jitter measurement circuit for mixed-signal production test based on the interpolation algorithm is presented. By utilizing the limited sampling points per cycle, the original signal under test is reconstructed with a high accuracy. From the reconstructed signal, most timing jitter features can be characterized. To validate the design effectiveness, comparative studies have been performed between this jitter measurement method and other standard jitter characterization instruments
The Minimal Time Required to Process Visual Information in Visual Search Tasks Measured by Using Gaze-Contingent Visual Masking

To estimate the minimal time required to process visual information (ie “effective acquisition time”) during a visual search task, we used a gaze-contingent visual masking method. In the experiment, an opaque mask that restricted the central vision was presented at a current gaze position. We manipulated a temporal delay from a gaze shift to mask movement. Participants were asked to search for a target letter (T) among distractor letters (L)s as quickly as possible under various delays. The results showed that the reaction times and search rate decreased when the delay was increased. When the delay was longer than 50 ms, the reaction times and search rate reached a plateau. These results indicate that the effective acquisition time during the visual search task used in the study is equal to or less than 50 ms. The present study indicates that the gaze-contingent visual masking method used is useful for revealing the effective acquisition time.
Development of a questionnaire for identifying driver's personal values in driving

The speed behavior of drivers is influenced by their personal driving values. It is assumed that these personal values may differ between drivers. In this paper, we describe the development of the Personal Driving Values (PDV) questionnaire. The questionnaire is to be used as a means of identifying personal values of drivers underlying their speed behavior. The development of the questionnaire items was inspired by other driving questionnaires, but the aim is to extract factors that represent the personally relevant values in driving. A questionnaire consisting of 49 items was distributed to 250 drivers. An exploratory factor analysis resulted in a final 25-item questionnaire addressing six different driving values: Sustainable Driving, Driving Fun, Driving Relaxed, Safe Driving, Driving Efficiency (Time) and Avoiding Fines.
Non‐linear optical microscopy of kidney tumours

The unregulated cancer cell growth leads to strong alterations in morphology and composition of the tissue. The combination of coherent anti‐Stokes Raman scattering, two‐photon excited fluorescence and second harmonic generation enables a high resolution imaging with strong information on tissue composition and can then provide useful information for tumour diagnosis. Here we present the potential of multimodal non‐linear microscopy for imaging of renal tumours. Using cryosections of human oncocytoma and carcinoma, the method gave a detailed insight in cancer morphology and composition, enabling to discern between normal kidney tissue, tumour and necrosis. Several features significant for the diagnosis were clearly visualised without use of any staining. Translation of this method in clinical pathology will greatly improve speed and quality of the analyses. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Active Surveillance for Adverse Events After a Mass Vaccination Campaign With a Group A Meningococcal Conjugate Vaccine (PsA-TT) in Mali

Background. The monovalent meningococcal A conjugate vaccine (PsA-TT, MenAfriVac) was developed for use in the “meningitis belt” of sub-Saharan Africa. Mali was 1 of 3 countries selected for early introduction. As this is a new vaccine, postlicensure surveillance is particularly important to identify and characterize possible safety issues. Methods. The national vaccination campaign was phased from September 2010 to November 2011. We conducted postlicensure safety surveillance for PsA-TT in 40 government clinics from southern Mali serving approximately 400 000 people 1–29 years of age. We conducted analyses with individual-level data and population-level data, and we calculated rates of adverse events using the conditional exact test, a modified vaccine cohort risk interval method, and a modified self-controlled case series method for each outcome of interest, including 18 prespecified adverse events and 18 syndromic categories. Results. An increased rate of clinic visits for fever within 3 days after vaccination was found using multiple methods for all age groups. Although other signals were found with some methods, complete assessment of all other prespecified outcomes and syndromic categories did not reveal that PsA-TT was consistently associated with any other health problem. Conclusions. No new safety concerns were identified in this study. These results are consistent with prelicensure data and other studies indicating that PsA-TT is safe. The approach presented could serve as a model for future active postlicensure vaccine safety monitoring associated with large-scale immunization campaigns in low-income countries.
Genetic characterization of a recombinant myxoma virus leap into the Iberian hare (Lepus granatensis)

Myxomatosis is a lethal disease of wild European and domestic rabbits (Oryctolagus cuniculus) caused by a Myxoma virus (MYXV) infection, a leporipoxvirus that is found naturally in some Sylvilagus rabbit species in South America and California. The introduction of MYXV in the early 1950s into feral European rabbit populations in Australia and Europe demonstrate the best documented field example of host-virus coevolution following a cross-species transmission. Recently, a new cross-species jump of MYXV has been suggested in both Great Britain and Spain, where European brown hares (Lepus europaeus) and Iberian hares (Lepus granatensis) were found dead with lesions consistent with those observed in myxomatosis. To investigate the possibility of a new cross-species transmission event by MYXV, tissue samples collected from a wild Iberian hare found dead in Spain (Toledo region) were analyzed and deep sequenced. Our results report a new MYXV strain (MYXV Toledo) in the tissues of this species. The genome of this new strain encodes three disrupted genes (M009L, M036L and M152R) and a novel 2.8 KB recombinant region that resulted from an insertion of four novel poxviral genes towards the 5’ end of its genome. From the open reading frames inserted into the MYXV Toledo strain, a new orthologue of a poxvirus host range gene family member was identified which is related to the MYXV gene M064R. Overall, we confirmed the identity of a new MYXV strain in Iberian hares that we hypothesize was able to more effectively counteract the host defenses in hares and start an infectious process in this new host.
An Event-Driven Demand Response Scheme for Power System Security Enhancement

Demand response has become a key feature of the future smart grid. In addition to having advanced communication and computing infrastructures, a successful demand response program must respond to the needs of a power system. In other words, the efficiency and security of a power system dictate the locations, amounts and speeds of the load reductions of a demand response program. In this paper, we propose an event-driven emergency demand response scheme to prevent a power system from experiencing voltage collapse. A technique to design such a scheme is presented. This technique is able to provide key setting parameters such as the amount of demand reductions at various locations to arm the demand response infrastructure. The validity of the proposed technique has been verified by using several test power systems.
Androgen receptor CAG repeat length correlates with semen PSA levels in adolescence

Androgens exert their action through the androgen receptor (AR). The length of the AR CAG repeat is inversely correlated to receptor function and short CAG length might be a risk factor for development of prostate cancer. Our aim was to investigate whether CAG repeat number might have an impact on prostate function in adolescence.
Assessment of potential hazards during the process of house building in Estonia

Abstract The aim of this study was to evaluate new working conditions in the construction industry in Estonia. Three construction sites were investigated: a dwelling house at the stage of renovation, a warehouse at the stage of excavation and preparation work, and a hotel, where we examined the working conditions of the finishers. Microclimate: air temperature, relative humidity and air velocity were determined at every workplace. Full-shift personal exposure measurements of dust and gas exposure were performed among 97 construction workers in breathing zone air. The concentration of lead in the air was analysed by AAS. Vapours of benzene, styrene and toluene concentrations were determined by gas chromatography. The noise level was measured with the help of the sound-level meter at every workplace. All microclimatic indices were sometimes below or above exposure standards for indoor work. High levels of airborne dust and increased concentrations of lead were observed during repair work. Low concentrations of organic solvents in the air were determined when using paints and some synthetic substances. The noise level exceeded the permitted limit when an excavator and powerful electric appliances were used. A questionnaire determined the prevalence of subjectively experienced musculoskeletal strain in 30% of workers. The working conditions in the construction industry in Estonia are approaching European level. However, it is necessary to improve working conditions permanently by the use of new harmless materials, personal protective equipment, and through influencing worker health by permanent education and medical watch. We consider that questionnaires are very important in the control of the work environment, in subjective health assessments, and as a source of useful proposals to improve working conditions.
ESTUDO FITOQUÍMICO E POTENCIAL ANTIBACTERIANO DO LÁTEX DE Himatanthus drasticus (MART.) PLUMEL

Himatanthus drasticus (Mart.) Plumel, popularly known as janaguba, is a latex medicinal plant widely used in the region of Cariri (CE) and used as an alternative source for the treatment of numerous diseases. The objective of the present work was to test the antibacterial and modulatory potential of the latex in natura (LIHD) and ethyl acetate extract of H. drasticus latex (EAEHD) alone and in combination with aminoglycoside antibiotics (amikacin and gentamicin) against standard and multiresistant strains, following the method of microdilution in Brain Heart Infusion (BHI) broth. In the evaluation of the minimum inhibitory concentration (MIC) results were obtained ≥ 1024 μg / mL against the standard strains of Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa and Klebsiella pneumoniae for both LIHD and EAEHD. The natural products presented synergism in the activity of the aminoglycosides to strains of multiresistant bacteria Escherichia coli (EC 27), Staphylococcus aureus (SA 358) and Klebsiella pneumoniae (KP 10031), however they presented antagonism to Pseudomonas aeruginosa (PA 03). In the quantification of phenols, LIHD had 62.6 mg / g and EAEHD 51.8 mg / g gallic acid / g extract, and for total flavonoids, LIHD had 16.5 and EAEHD had 13.4 mg / g of flavonoids. Further research is needed for a possible use of these natural products combined with antimicrobials tested (aminoglycosides) against pathogenic strains. Through the results it was concluded that the natural products represent promising sources in the fight against bacterial resistance. Keywords: Aminoglycosides; Antimicrobian activity; Inhibitory Minimum Concentration; Himatanthus drasticus .
Precisionof DeterminatIonof PlasmaProteInsin Urineby Use of A . I . P . with Interfaceand Desk-topCalculator , by Manual and AutomatIc Peak-heightMeasurementandAutomaticIntegratIon

CLINICAL CHEMISTRY, Vol. 23, No. 6, 1977 1189 +2.73% (Table 1). However, the “forward” technique manifested both constant (non-zero intercept; t = -4.0, P < 0.05) and pipette-size related (slope significantly <1.0; t = 5.27, P <0.01) inaccuracies. Deviations ranged from -6.31% to -12.0% of the intended value. Precision was similar using either technique (coefficients of variation, Table 1). We routinely use this method in our laboratories to pipette blood and blood products and find that it improves our accuracy.
Stability and bifurcation analysis for a congestion control model with caputo fractional derivative and time delay

This paper proposes a delayed fractional-order model which is more accurate than the original integer-order model when depicting dual congestion control algorithms. Some sufficient conditions for the local stability are derived for the delayed fractional-order model of congestion control algorithms. Hopf bifurcation conditions are put forward for general delayed fractional-order systems. Then the existence of Hopf bifurcations is established for the delayed fractional-order congestion control model. The critical values of the delay are determined, where the Hopf bifurcations occur and a family of oscillations bifurcate from the equilibrium. Finally, numerical simulations are carried out to illustrate the main results.
A web-based platform of nucleotide sequence alignments of plants

In recent years, a large number of nucleotide sequences have become available for plant species by the advent of massive parallel sequencing. The use of genomic data has been important for agriculture, food science, medicine or ecology. Despite the increasing amount of data, nucleotide sequences are usually available in public databases as isolated records with some descriptive information. Researchers interested in studying a wide range of specific plant families are forced to do multiple searches, sequence downloads, data curation and sequence alignments. In order to help researches overcoming these problems, we have built a comprehensive on-line resource of curated nucleotide sequence alignments for plant research, named PlantAligDB (available at http://plantaligdb.portugene.com). The latest release incorporates 514 alignments with a total of 66,052 sequences from six important genomic regions: atpF-atpH, psbA-trnH, trnL, rbcL, matK and ITS. The alignments represent 223 plant families from a variety of taxonomic groups. The users can quickly search the database, download and visualize the curated alignments and phylogenetic trees using dynamic browser-based applications. Different measures of genetic diversity are also available for each plant family. We also provide the workflow script that allows the user to do the curation process, explaining the steps involved. Overall, the PlantAligDB provides a complete, quality checked and regularly updated collection of alignments that can be used in taxonomic, DNA barcoding, molecular genetics, phylogenetic and evolutionary studies.
Restructuring in Place: Japanese Investment, Production Organization, and the Geography of Steel

AbstractJapanese investment has set in motion a restructuring of the U.S. steel industry. This restructuring is occurring on three related geographic scales. At the global scale, Japanese investment in U.S. steel reflects a more general shift in the center of steel production technology and accumulation from the U.S. and western Europe to Japan. Japanese advances are now diffusing back to the U.S. via Japanese direct investment and organizational restructuring. At the national level, within the U.S., Japanese investment reinforces a westward shift in the center of steel production from the traditional Pittsburgh region to Ohio, Michigan, and Indiana. This spatial redirection stems from the high fixed costs of integrated steel production, the importance of the automobile industry as a user of steel, and the particular requirement of supplying steel to the automotive transplants and their suppliers on a just-in-time basis. At the plant or organizational level, Japanese direct investment has set in motion a .
STATISTICAL MODELLING OF SEA CLUTTER IN AIRBORNE S-BAND FULLY POLARIMETRIC SYNTHETIC APERTURE RADAR IMAGERY

This paper presents statistical modelling of sea clutter in airborne S-band fully polarimetric synthetic aperture radar (SAR) data. The modelling was performed by using squared radius and trace statistic for singlelook and multilook fully polarimetric SAR data, respectively. Both homogeneous and texture models were investigated and evaluated quantitatively. From the obtained results, it was found that texture model showed a better agreement in sea clutter modelling compared with homogeneous model.
Brain tumor classification and segmentation using sparse coding and dictionary learning

Abstract This paper presents a novel fully automatic framework for multi-class brain tumor classification and segmentation using a sparse coding and dictionary learning method. The proposed framework consists of two steps: classification and segmentation. The classification of the brain tumors is based on brain topology and texture. The segmentation is based on voxel values of the image data. Using K-SVD, two types of dictionaries are learned from the training data and their associated ground truth segmentation: feature dictionary and voxel-wise coupled dictionaries. The feature dictionary consists of global image features (topological and texture features). The coupled dictionaries consist of coupled information: gray scale voxel values of the training image data and their associated label voxel values of the ground truth segmentation of the training data. For quantitative evaluation, the proposed framework is evaluated using different metrics. The segmentation results of the brain tumor segmentation (MICCAI-BraTS-2013) database are evaluated using five different metric scores, which are computed using the online evaluation tool provided by the BraTS-2013 challenge organizers. Experimental results demonstrate that the proposed approach achieves an accurate brain tumor classification and segmentation and outperforms the state-of-the-art methods.
Functional analysis and nucleotide sequence of the promoter region of the murine hck gene

The structure and function of the promoter region and exon 1 of the murine hck gene have been characterized in detail. RNase protection analysis has established that hck transcripts initiate from heterogeneous start sites located within the hck gene. Fusion gene constructs containing hck 5'-flanking sequences and the bacterial Neor gene have been introduced into the hematopoietic cell lines FDC-P1 and WEHI-265 by using a self-inactivating retroviral vector. The transcriptional start sites of the fusion gene are essentially identical to those of the endogenous hck gene. Analysis of infected WEHI-265 cell lines treated with bacterial lipopolysaccharide (LPS) reveals a 3- to 5-fold elevation in the levels of endogenous hck mRNA and a 1.4- to 2.6-fold increase in the level of Neor fusion gene transcripts, indicating that hck 5'-flanking sequences are capable of conferring LPS responsiveness on the Neor gene. The 5'-flanking region of the hck gene contains sequences similar to an element which is thought to be involved in the LPS responsiveness of the class II major histocompatibility gene A alpha k. A subset of these sequences are also found in the 5'-flanking regions of other LPS-responsive genes. Moreover, this motif is related to the consensus binding sequence of NF-kappa B, a transcription factor which is known to be regulated by LPS.