Miracle-dz/UniFAR-FTUs huggingface dataset:
Serum Paraoxonase/Arylesterase Activity and Oxidative Stress Status in Children with Metabolic Syndrome

Objective: This study aimed to measure paraoxonase/arylesterase activities and to evaluate the total oxidant and antioxidant capacities in obese children and in children with metabolic syndrome (MetS). Methods: A total of 151 children of comparable ages (13.23±1.96 years, 13.45±1.85 years and 13.95±1.31 years) were enrolled in the study. Forty of these were children with MetS, 55 were obese and 56 were healthy controls. Diagnosis of the MetS was made according to International Diabetes Federation criteria. Paraoxonase/arylesterase activities were evaluated by using paraoxon and phenylacetate substrates. Total oxidant status (TOS) and total antioxidant status (TAS) were measured and oxidative stress index (OSI) was estimated by calculation. Results: High levels of paraoxonase were detected in the obese group, whereas high levels of arylesterase were detected in both MetS and obese groups. Higher values for TOS, TAS and OSI were found in the MetS group (p<0.05). Conclusion: Higher values of mean TOS and OSI in the MetS group than those in the control groups indicate that these parameters may be indicators of future risks such as atherosclerosis in patients with MetS.
Improving Availability of Cloud-Based Applications through Deployment Choices

Deployment choices are critical in determining the availability of applications running in a cloud. But choosing good deployment for various software application components into virtual machines is a challenging task because of potential sharing of components among applications and potential interference from multi-tenancy. This paper presents an approach for improving the availability guarantee of software applications by optimizing the availability, performance and monetary cost trade-offs of different deployment choices. Our approach explicitly considers different classes of application requests during the decision process. The results of our experimental evaluation show that the approach can effectively improve the availability guarantees with little or negligible increase in the performance and monetary cost of the deployment choice.
A reliable many-to-many multicast protocol for group communication over ATM networks

Reliable many-to-many multicasting of messages is an integral part of group communication systems. Such systems typically employ a reliable multicast protocol that operates below the causal or total ordering layer of the protocol stack. In this paper, we present ARMP, a reliable many-to-many multicast protocol for group communication over wide-area ATM networks. We describe how the ATM environment affects the design of ARMP, which differs significantly from the design of reliable multicast protocols intended for other environments.
On the Rate of Convergence of a Partially Asynchronous Gradient Projection Algorithm

Recently, Bertsekas and Tsitsiklis proposed a partially asynchronous implementation of the gradient projection algorithm of Goldstein and Levitin and Polyak for the problem of minimizing a differentiable function over a closed convex set. In this paper, the rate of convergence of this algorithm is analyzed. It is shown that if the standard assumptions hold (that is, the solution set is nonempty and the gradient of the function is Lipschitz continuous) and (i) the isocost surfaces of the objective function, restricted to the solution set, are properly separated and (ii) a certain multifunction associated with the problem is locally upper Lipschitzian, then this algorithm attains a linear rate of convergence.
A micro-constraint model of Optimality Theory: Do infants learn universal constraints?

Does Optimality Theory offer a basis for a neurologically plausible model of language? This paper examines the case for Optimality Theory as a plausible model of language, and suggests modifications to the theory that would improve the biological plausibility, learnability, and coherence of the model. The micro-constraint model which emerges from these modifications, suggests that language, and linguistic universal behaviour is learned by settling upon an arbitrary set micro-constraints, rather than acquiring or ranking innate constraints as specified by Optimality Theory. The validity of this micro-constraint model is tested using a Simple Recurrent Network model of speech syllabification, and some support is found for the claim that arbitrary micro-constraints might reproduce universal constraints. However, we suggest that further work, with fewer assumptions about the nature of the speech stream is needed in order to improve the conclusiveness of the result.
New Data on Human Macrophages Polarization by Hymenolepis diminuta Tapeworm—An In Vitro Study

Helminths and their products can suppress the host immune response to escape host defense mechanisms and establish chronic infections. Current studies indicate that macrophages play a key role in the immune response to pathogen invasion. They can be polarized into two distinct phenotypes: M1 and M2. The present paper examines the impact of the adult Hymenolepis diminuta (HD) tapeworm and its excretory/secretory products (ESP) on THP-1 macrophages. Monocytes were differentiated into macrophages and cultured with a living parasite or its ESP. Our findings indicate that HD and ESP have a considerable impact on human THP-1 macrophages. Macrophages treated with parasite ESP (with or without LPS) demonstrated reduced expression of cytokines (i.e., IL-1α, TNFα, TGFβ, IL-10) and chemokines (i.e., IL-8, MIP-1α, RANTES, and IL-1ra), while s-ICAM and CxCL10 expression rose after ESP stimulation. In addition, inflammatory factor expression rose significantly when macrophages were exposed to living parasites. Regarding induced and repressed pathways, significant differences were found between HD and ESP concerning their influence on the phosphorylation of ERK1/2, STAT2, STAT3, AMPKα1, Akt 1/2/3 S473, Hsp60, and Hck. The superior immunosuppressive properties of ESP compared to HD were demonstrated with lower levels of IL-1β, TNF-α, IL-6, IL-23, and IL-12p70 following stimulation. The presence of HD and its ESP were found to stimulate mixed M1/M2 macrophage phenotypes. Our findings indicate new molecular mechanisms involved in the response of human macrophages to tapeworm infection, this could be a valuable tool in understanding the mechanisms underlying the processes of immune regulation during cestodiasis.
Primary Tumor Characteristics Are Important Prognostic Factors for Sorafenib-Treated Patients with Metastatic Renal Cell Carcinoma: A Retrospective Multicenter Study

We aimed to identify prognostic factors associated with progression-free survival (PFS) and overall survival (OS) in metastatic renal cell carcinoma (mRCC) patients treated with sorafenib. We investigated 177 patients, including 116 who received sorafenib as first-line therapy, using the Cox regression model. During a median follow-up period of 19.2 months, the PFS and OS were 6.4 and 32.6 months among all patients and 7.4 months and undetermined for first-line sorafenib-treated patients, respectively. Clinical T3-4 stage (hazard ratio [HR] 2.56) and a primary tumor size >7 cm (HR 0.34) were significant prognostic factors for PFS among all patients, as were tumor size >7 cm (HR 0.12), collecting system invasion (HR 5.67), and tumor necrosis (HR 4.11) for OS (p < 0.05). In first-line sorafenib-treated patients, ≥4 metastatic lesions (HR 28.57), clinical T3-4 stage (HR 4.34), collecting system invasion (univariate analysis HR 2.11; multivariate analysis HR 0.07), lymphovascular invasion (HR 13.35), and tumor necrosis (HR 6.69) were significant prognosticators of PFS, as were bone metastasis (HR 5.49) and clinical T3-4 stages (HR 4.1) for OS (p < 0.05). Our study thus identified a number of primary tumor-related characteristics as important prognostic factors in sorafenib-treated mRCC patients.
A Correntropy-based voice to MIDI transcription algorithm

In this paper we describe an automatic voice-to-MIDI transcription procedure. In particular we propose a note segmentation method based on the analysis of the signal envelope and its derivative. The pitch of the segmented note is extracted with a novel generalized correlation function called correntropy function achieving high accuracy with the same computational cost of traditional correlation based methods. The performances of our transcription system have been measured on examples extracted by some repositories available on internet; they consist in sung melodies and hummed queries. Results show the ability of our transcription procedure to cope with query-by-humming systems, as well as with monophonic singing transcription. Performances can be easily evaluated by downloading from the authors web site the original PCM files and the corresponding MIDI files produced by the proposed transcription algorithm.
Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems

Neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease(AD), are a group of pathologies characterized by a progressive and specific loss of certain brain cell populations. Oxidative stress, mitochondrial dysfunction, and apoptosis play interrelated roles in these disorders. It is well documented that free radical oxidative damage, particularly on neuronal lipids, proteins, DNA, and RNA, is extensive in PD and AD brains. Moreover, alterations of glutathione (GSH) metabolism in brain have been implicated in oxidative stress and neurodegenerative diseases. As a consequence, the reduced GSH levels observed in these pathologies have stimulated a number of researchers to find new potential approaches for maintaining or restoring GSH levels. Unfortunately, GSH delivery to the central nervous system (CNS) is limited due to a poor stability and low bioavailability. Medicinal-chemistry- and technology-based approaches are commonly used to improve physicochemical, biopharmaceutical, and drug delivery properties of therapeutic agents. This paper will focus primarily on these approaches used in order to replenish intracellular GSH levels, which are reduced in neurodegenerative diseases. Here, we discuss the beneficial properties of these approaches and their potential implications for the future treatment of patients suffering from neurodegenerative diseases, and more specifically from PD and AD.
The Tasks of the Crowd: A Typology of Tasks in Geographic Information Crowdsourcing and a Case Study in Humanitarian Mapping

In the past few years, volunteers have produced geographic information of different kinds, using a variety of different crowdsourcing platforms, within a broad range of contexts. However, there is still a lack of clarity about the specific types of tasks that volunteers can perform for deriving geographic information from remotely sensed imagery, and how the quality of the produced information can be assessed for particular task types. To fill this gap, we analyse the existing literature and propose a typology of tasks in geographic information crowdsourcing, which distinguishes between classification, digitisation and conflation tasks. We then present a case study related to the “Missing Maps” project aimed at crowdsourced classification to support humanitarian aid. We use our typology to distinguish between the different types of crowdsourced tasks in the project and choose classification tasks related to identifying roads and settlements for an evaluation of the crowdsourced classification. This evaluation shows that the volunteers achieved a satisfactory overall performance (accuracy: 89%; sensitivity: 73%; and precision: 89%). We also analyse different factors that could influence the performance, concluding that volunteers were more likely to incorrectly classify tasks with small objects. Furthermore, agreement among volunteers was shown to be a very good predictor of the reliability of crowdsourced classification: tasks with the highest agreement level were 41 times more probable to be correctly classified by volunteers. The results thus show that the crowdsourced classification of remotely sensed imagery is able to generate geographic information about human settlements with a high level of quality. This study also makes clear the different sophistication levels of tasks that can be performed by volunteers and reveals some factors that may have an impact on their performance.
The transcription factor E2F-1 is a downstream target of RB action

Reintroduction of RB into SAOS2 (RB-/-) cells causes a G1 arrest and characteristic cellular swelling. Coexpression of the cellular transcription factor E2F-1 could overcome these effects. The ability of E2F-1 to bind to RB was neither necessary nor sufficient for this effect, and S-phase entry was not accompanied by RB hyperphosphorylation under these conditions. Furthermore, E2F-1 could overcome the actions of a nonphosphorylatable but otherwise intact RB mutant. These data, together with the fact that RB binds to E2F-1 in vivo, suggest that E2F-1 is a downstream target of RB action. Mutational analysis showed that the ability of E2F-1 to bind to DNA was necessary and sufficient to block the formation of large cells by RB, whereas the ability to induce S-phase entry required a functional transactivation domain as well. Thus, the induction of a G1 arrest and the formation of large cells by RB in these cells can be genetically dissociated. Furthermore, the ability of the E2F-1 DNA-binding domain alone to block one manifestation of RB action is consistent with the notion that RB-E2F complexes actively repress transcription upon binding to certain E2F-responsive promoters. In keeping with this view, we show here that coproduction of an E2F1 mutant capable of binding to DNA, yet unable to transactivate, is sufficient to block RB-mediated transcriptional repression.
Multimodal analgesic treatment in video-assisted thoracic surgery lobectomy using an intraoperative intercostal catheter.

OBJECTIVES No golden standard for analgesia in video-assisted thoracic surgery (VATS) lobectomy exists. A simple multimodal approach using an intercostal catheter (ICC) may be of benefit since acute post-operative pain following VATS lobectomy primarily originates from the chest drain area. METHODS Prospective observational cohort. Forty-eight consecutive patients received a standardized regimen consisting of paracetamol, non-steroidal anti-inflammatory drug and gabapentin. Further, surgeons performed a single-shot paravertebral block (PVB) at five levels (15 ml of 0.5% bupivacaine) and inserted an ICC at the drain site level for continuous delivery of 6 ml of 0.25% bupivacaine h(-1). Pain scores at rest, mobilization and with the extended arms were followed until discharge or for 4 days. RESULTS Forty-eight patients, mean age 64 years (CI: 61-68), were included. The mean time for the PVB and ICC placement was 5 min (CI: 4.7-5.9). The mean pain score at rest using a numerical rating scale (NRS, 0-10) was <3 for 1-16 h and decreased from 4.7 to 1.7 (NRS day 1-4, getting out of bed). The ICC was removed with the drain in 48/73/92% on day 1/2/3 after surgery. The median day of discharge was 3 (interquartile range 2-4) with >85% of patients reporting satisfactory or very satisfactory pain treatment all days. CONCLUSIONS Acute pain after VATS lobectomy may be adequately controlled using a multimodal non-opioid regime including PVB and an ICC. The low pain scores and reduced time used inserting the ICC may present an alternative to continuous epidural analgesia or conventional PVB.
Mechanisms controlling primary and new production in a global ecosystem model Part II: The role of the upper ocean short-term periodic and episodic mixing events

The use of 6 h, daily, weekly and monthly atmospheric forcing resulted in dramatically different predictions of plankton productivity in a global 3-D coupled physicalbiogeochemical model. Resolving the diurnal cycle of atmospheric variability by use of 6 h forcing, and hence also diurnal variability in UML depth, produced the largest difference, reducing predicted global primary and new production by 25% and 10% respectively relative to that predicted with daily and weekly forcing. This decrease varied regionally, being a 30% reduction in equatorial areas primarily because of increased light limitation resulting from deepening of the mixed layer overnight as well as enhanced storm activity, and 25% at moderate and high latitudes primarily due to increased grazing pressure resulting from late winter stratification events. Mini-blooms of phytoplankton and zooplankton occur in the model during these events, leading to zooplankton populations being sufficiently well developed to suppress the progress of phytoplankton blooms. A 10% increase in primary production was predicted in the peripheries of the oligotrophic gyres due to increased storm-induced nutrient supply end enhanced winter production during the short term stratification events that are resolved in the run forced by 6 h meteorological fields. By resolving the diurnal cycle, model performance was significantly improved with respect to several common problems: underestimated primary production in the oligotrophic gyres; overestimated primary production in the Southern Ocean; overestimated magnitude of the spring bloom in the subarctic Pacific Ocean, and overestimated primary production in equatorial areas. The result of using 6 h forcing on predicted ecosystem dynamics was profound, the effects persisting far beyond the hourly timescale, and having major consequences for predicted global and new production on an annual basis.
Speed of eating and 3-year BMI change: a nationwide prospective study of mid-age women

Abstract Objective To conduct the first nationwide population survey to examine the associations between changes in speed of eating and weight gain over 3 years. The study also explored whether faster eating at baseline was related to healthy-weight women becoming overweight after 3 years. Design Longitudinal. At baseline, participants were randomly selected from a nationally representative sampling frame to participate in a prospective study. Women completed self-administered baseline questionnaires on demographic and health measures. Self-reported speed of eating, smoking status, physical activity, menopause status, and height and weight were collected at baseline and again 3 years later. Setting Nationwide study, New Zealand. Subjects Women (n 1601) aged 40–50 years were recruited at baseline from New Zealand electoral rolls. Results There was no evidence of associations between 3-year BMI adjusting for baseline BMI and either baseline speed of eating (slower and faster; P=0·524) or change in speed of eating (consistently faster eating, consistently slower eating, slower eating at baseline but not at 3 years, faster eating at baseline but not at 3 years; P=0·845). Of the 488 women with healthy BMI (18·5 to <25·0 kg/m2) at baseline, seventy-seven (15·8 %) became overweight (BMI≥25·0 kg/m2) after 3 years. Compared with those who were slower eaters at baseline, faster eating at baseline did not increase the risk of becoming overweight 3 years later (P=0·958) nor did change in speed of eating (P=0·236). Conclusions Results suggest that once women have reached mid-life, faster eating does not predict further weight gain.
Relationship dissolution following marital infidelity: comparing European Americans and Asian Americans

Abstract The present study examined how attitudes toward divorce as well as the Investment Model relate to the decision to divorce following a spouse's infidelity among European Americans and Asian/Asian Americans. Participants were 325 participants (155 male, 170 female) who completed a survey. Structural Equation Modeling was employed to test the hypotheses. Overall, the model showed that gender, personal income, infidelity type, quality of alternative, commitment, and divorce attitudes are associated with the stay/leave decision. Ethnicity moderated these relationships as the investment model variables are associated with European American participants' decision-making whereas for Asian Americans, only attitude toward divorce was a strong predictor. These findings suggest European Americans and Asian Americans weigh different factors when making the decision to divorce or remain together. Understanding the variables associated with stay/leave decisions, particularly with a cross-cultural lens, provides insight into why some individuals remain together following an infidelity.
Compact frequency multiplier using an artificial left-handed transmission line

This paper presents a compact size frequency doubler using an artificial transmission line design approach. The multiplier features conversion gain and high fundamental signal rejection. The frequency multiplying is employing the current combining push-push technique. Two GaAs FETs are driven by 900 MHz anti-phase signals from a simple LHM-TL phase shifter instead of the conventional balun/power divider. The transistor can be loaded directly onto the input and output port of the LHM-TL phase shifter since FETs virtually need no input power. The experimental results show the excellent agreements between the design and ADS® simulations. The frequency doubler has a conversion gain of 5 dB and 30 % of size reduction compare to the conventional transmission line/hybrid circuit implementation.
Grammar Viewed as a Functional Part of a Cognitive System

How can grammar be viewed as a functional part of a cognitive system? Given a neural basis for the processing control paradigm of language performance, what roles does "grammar" play? Is there evidence to suggest that grammatical processing can be independent from other aspects of language processing? This paper will focus on these issues and suggest answers within the context of one computational solution. The example model of sentence comprehension, HOPE, is intended to demonstrate both representational considerations for a grammar within such a system as well as to illustrate that by interpreting a grammar as a feedback control mechanism of a "neural-like" process, additional insights into language processing can be obtained.
Effects of Prenatal Testosterone Exposure on Sexually Dimorphic Gene Expression in the Neonatal Mouse Cortex and Hippocampus.

OBJECTIVE Using gene expression microarrays and reverse transcription with quantitative polymerase chain reaction (RT-qPCR), we have recently identified several novel genes that are differentially expressed in the neonatal male versus female mouse cortex/hippocampus (Armoskus et al.). Since perinatal testosterone (T) secreted by the developing testes masculinizes cortical and hippocampal structures and the behaviors regulated by these brain regions, we hypothesized that sexually dimorphic expression of specific selected genes in these areas might be regulated by T during early development. METHODS To test our hypothesis, we treated timed pregnant female mice daily with vehicle or testosterone propionate (TP) starting on embryonic day 16 until the day of birth. The cortex/hippocampus was collected from vehicle- and TP-treated, male and female neonatal pups. Total RNA was extracted from these brain tissues, followed by RT-qPCR to measure relative mRNA levels of seven sex chromosome genes and three autosomal genes that have previously showed sex differences. RESULTS The effect of prenatal TP was confirmed as it stimulated Dhcr24 expression in the neonatal mouse cortex/hippocampus and increased the anogenital distance in females. We found a significant effect of sex, but not TP, on expression of three Y-linked (Ddx3y, Eif2s3y, and Kdm5d), four X-linked (Eif2s3x, Kdm6a, Mid1, and Xist), and one autosomal (Klk8) genes in the neonatal mouse cortex/hippocampus. CONCLUSION Although most of the selected genes are not directly regulated by prenatal T, their sexually dimorphic expression might play an important role in the control of sexually differentiated cognitive and social behaviors as well as in the etiology of sex-biased neurological disorders and mental illnesses.