Miracle-dz/UniFAR-FTUs huggingface dataset:
Oral ( 1 3 3 ) , ( 1 3 4 )-- D-Glucan Synergizes with Antiganglioside GD 2 Monoclonal Antibody 3 F 8 in the Therapy of Neuroblastoma 1

Purpose: In vitro -glucan can enhance tumor cytotoxicity through iC3b receptors on leukocytes. We tested if (133),(134)-D-glucan ( -glucan) can synergize with antiGD2 monoclonal antibody (MoAb) 3F8 (mouse IgG3) in therapy of human neuroblastoma xenografts. Experimental Design: Athymic nude mice with established neuroblastoma xenografts were treated with daily i.p. or p.o. -glucan, in the presence/absence of i.v. MoAb twice a week, for 22–29 days. Serial tumor volumes and body weights were monitored. Results: 3F8 plus -glucan produced near-complete tumor regression/disease stabilization, whereas 3F8 or glucan alone did not significantly affect tumor growth. For NMB7 tumors, median survival of 3F8 plus -glucan group was 5.5-fold that of control groups (P < 0.001), and for LAN-1, the survival difference was 2.6-fold. Forty-seven percent of the mice with NMB7 and 18% with LAN-1 remained progression free in contrast to <3% of controls. Antitumor effect was seen at >40 g of glucan dose, i.v. or p.o. , and in all human neuroblastoma cell lines tested. No toxicities were noted in mice treated with either -glucan alone or 3F8 plus -glucan (4–4000 g/dose). In contrast to anti-GD2 MoAb 3G6 (IgM), 3F8 F(ab )2 and MoAb 8H9 (IgG1) did not activate complement and had no synergy with -glucan. Antitumor effect of 3F8 plus p.o. -glucan persisted after antiasialo-GM1 antibody treatment, as well as in
The Crd1 gene encodes a putative di‐iron enzyme required for photosystem I accumulation in copper deficiency and hypoxia in Chlamydomonas reinhardtii

Chlamydomonas reinhardtii adapts to copper deficiency by degrading apoplastocyanin and inducing Cyc6 and Cpx1 encoding cytochrome c6 and coproporphyrinogen oxidase, respectively. To identify other components in this pathway, colonies resulting from insertional mutagenesis were screened for copper‐ conditional phenotypes. Twelve crd (copper response defect) strains were identified. In copper‐deficient conditions, the crd strains fail to accumulate photosystem I and light‐harvesting complex I, and they contain reduced amounts of light‐harvesting complex II. Cyc6, Cpx1 expression and plastocyanin accumulation remain copper responsive. The crd phenotype is rescued by a similar amount of copper as is required for repression of Cyc6 and Cpx1 and for maintenance of plastocyanin at its usual stoichiometry, suggesting that the affected gene is a target of the same signal transduction pathway. The crd strains represent alleles at a single locus, CRD1, which encodes a 47 kDa, hydrophilic protein with a consensus carboxylate‐bridged di‐iron binding site. Crd1 homologs are present in the genomes of photosynthetic organisms. In Chlamydomonas, Crd1 expression is activated in copper‐ or oxygen‐deficient cells, and Crd1 function is required for adaptation to these conditions.
L'analyse comme procédé de la métaphysique. L'opposition à la méthodologie wolffienne dans la Preisschrift de Kant en 1763 (1764) in La spécificité des Lumières allemandes.

Dans la Recherche sur l'evidence des principes de la theologie naturelle et de la morale, Kant s'oppose au monisme wolffien des methodes scientifiques. Il distingue une methode synthetique, bonne p. ex. pour les mathematiques, et une methode analytique, necessaire a la philosophie, et specialement a la metaphysique. Cela est tres important pour la Critique de la raison pure.
Hyperbaric Oxygen Therapy In Calcium Chloride Extravasation Injuries: An Experimental Animal Study

Aim: Parenteral alimentation fluids containing calcium are widely used to treat sick neonates and children. Extravasation of calcium presents with local swelling, erythema, blistering and progresses to skin necrosis and skin loss. Several treatment modalities including hyperbaric oxygen therapy have been used for extravasation injuries. The role of hyperbaric oxygen therapy on extravasation injuries was investigated in this study by an experimental rat model based on facilitating effect of hyperbaric oxygen on wound healing. Methods: After shaving the dorsal side of 16 female Wistar rats, 1 ml of calcium chloride were injected intradermally. The rats were divided into two groups as control and hyperbaric oxygen. The control group received no treatment while the hyperbaric oxygen group received hyperbaric oxygen therapy for 7 days after injection. At the end of seventh day skin biopsy including all necrotic tissue and surrounding healthy tissue were obtained and histopathologic examination was performed for control and hyperbaric oxygen groups. Results: Hyperbaric oxygen group showed a statistically significant preservation of epidermis and dermis with minimal necrosing findings of skin injury. Conclusion: Although further research is required to develop management guidelines, we concluded that in this experimental study, hyperbaric oxygen therapy prevents dermal injury and may decrease the morbidity associated with calcium chloride extravasation injury.
Effects of electrical and thermal pre-treatment on mass transport in biological tissue

Le champ electrique d'une puissance suffisante peut provoquer une augmentation de conductivite et permeabilite de la membrane cellulaire. L'effet est connu comme l'electroporation, attribuee a la creation de voies aqueuses dans la membrane. Quantifier le transport de la matiere dans le cadre d'electroporation est un objectif important. Comprendre ces processus a des ramifications dans l’extraction du jus ou l’extraction selective des composes de cellules vegetales, l'amelioration de l'administration de medicaments, et des solutions aux defis environnementaux. Il y a un manque de modeles qui pourraient etre utilises pour modeliser le transport de la matiere dans les structures complexes (tissus biologiques) par rapport a l'electroporation. Cette these presente une description mathematique theorique (un modele) pour etudier le transport de la matiere et le transfert de la chaleur dans tissu traite par l’electroporation. Le modele a ete developpe en utilisant les lois de conservation et de transport et permet le couplage des effets de l'electroporation sur la membrane des cellules individuelles au transport de la matiere ou la chaleur dans le tissu. Une solution analytique a ete trouvee par une simplification, mais le modele peut etre etendu avec des dependances fonctionnelles supplementaires et resolu numeriquement. La these comprend cinq articles sur l'electroporation dans l'industrie alimentaire, la creation de modele pour le probleme de diffusion, la traduction du modele au probleme lie a l’expression de jus, validation du modele, ainsi que des suggestions pour une elaboration future du modele. Un chapitre supplementaire est dedie au transfert de la chaleur dans tissu.
Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control

GCN4 encodes a transcriptional activator of amino acid-biosynthetic genes in Saccharomyces cerevisiae that is regulated at the translational level by upstream open reading frames (uORFs) in its mRNA leader. uORF4 (counting from the 5' end) is sufficient to repress GCN4 under nonstarvation conditions; uORF1 is required to overcome the inhibitory effect of uORF4 and stimulate GCN4 translation in amino acid-starved cells. Insertions of sequences with the potential to form secondary structure around uORF4 abolish derepression, indicating that ribosomes reach GCN4 by traversing uORF4 sequences rather than by binding internally to the GCN4 start site. By showing that wild-type regulation occurred even when uORF4 was elongated to overlap GCN4 by 130 nucleotides, we provide strong evidence that those ribosomes which translate GCN4 do so by ignoring the uORF4 AUG start codon. This conclusion is in accord with the fact that translation of a uORF4-lacZ fusion was lower in a derepressed gcd1 mutant than in a nonderepressible gcn2 strain. We also show that increasing the distance between uORF1 and uORF4 to the wild-type spacing that separates uORF1 from GCN4 specifically impaired the ability of uORF1 to derepress GCN4 translation. As expected, this alteration led to increased uORF4-lacZ translation in gcd1 cells. Our results suggest that under starvation conditions, a substantial fraction of ribosomes that translate uORF1 fail to reassemble the factors needed for reinitiation by the time they scan to uORF4, but become competent to reinitiate after scanning the additional sequences to GCN4. Under nonstarvation conditions, ribosomes would recover more rapidly from uORF1 translation, causing them all to reinitiate at uORF4 rather than at GCN4.
Shear mode A1N thin film electroacoustic resonator for biosensor applications

A thin film thickness excited shear acoustic wave resonator is presented. Utilizing a newly developed reactive sputtering process AlN thin films with inclined c-axis relative to the surface normal with a mean tilt of around 30 are successfully grown. Using the above process, a biosensor consisting of a shear mode thin film bulk acoustic resonator (TFBAR) and a microfluidic transport system was fabricated. The biosensor operation in water, glycerol and albumin was characterised. The resonator had a resonance frequency of around 1.2 GHz and a Q value in water of around 150. The results demonstrate clearly the potential of FBAR biosensors for the fabrication of highly sensitive low cost biosensors, bioanalytical tools as well as for liquid sensing in general. Keywords-component; thickness mode resonator; quasishear polarased acoustic wave; FBAR; AlN; tilted films; biosensor;
Adenosine‐Sensitive Atrial Tachycardia

Limited data suggest that adenosine termination of atrial tachycardia is uncommon. To investigate further the effect of adenosine on atrial tachycardia, adenosine (6–12 mg) was administered during sustained atrial tachycardia in 17 patients. All patients underwent electrophysiological study to exclude other mechanisms of supraventricular tachycardia. Mean patient age was 51 ± 20 years (range 18–82 years). Seven patients had no structural heart disease. The mean atrial tachycardia cycle length was 390 ± 80 msecs (range 260–580). Sustained atrial tachycardia was induced with atrial extrastimuli in 8 patients, and was either incessant at baseline or developed spontaneously during isoproterenol infusion in 9 patients. Adenosine terminated atrial tachycardia in 3 patients (18%), transiently suppressed atrial tachycardia in 4 patients (23%), and produced AV block without affecting tachycardia cycle length in the remaining 10 patients. Adenosine sensitivity was observed in 3 of 8 patients with tachycardias initiated and terminated by atrial extrastimuli, and in 4 of 9 patients with spontaneous, but not inducible tachycardias including 3 of 4 patients with isoproterenol facilitated tachycardias. Of multiple clinical and electrophysiological variables examined as potential predictors of adenosine sensitivity, only isoproterenol facilitation of spontaneous or inducible sustained tachycardia predicted adenosine sensitivity (P = 0.02). These observations suggest that adenosine‐sensitive atrial tachycardia may be more common than previously recognized. Adenosine sensitivity does not appear to be specific for tachycardia mechanism and cannot be predicted by response to pacing. Atrial tachycardias dependent on β‐adrenergic stimulation are most likely to be terminated by adenosine.
Novel Gate-All-Around Poly-Si TFTs With Multiple Nanowire Channels

The novel gate-all-around (GAA) poly-Si thin-film transistors (TFTs) with multiple nanowire channels (MNCs) have been, for the first time, fabricated using a simple process to demonstrate high-performance electrical characteristics and high immunity to short-channel effects (SCEs). The nanowire channel with high body-thickness-to-width ratio (TFin/WFin), which is approximately equal to one, was realized only with a sidewall-spacer formation. Moreover, the unique suspending MNCs were also achieved to build the GAA structure. The resultant GAA-MNC TFTs showed outstanding three-dimensional (3-D) gate controllability and excellent electrical characteristics, which revealed a high on/off current ratio ( > 108), a low threshold voltage, a steep subthreshold swing, a near-free drain-induced barrier lowering, as well as an excellent SCE suppression. Therefore, such high-performance GAA-MNC TFTs are very suitable for applications in system-on-panel and 3-D circuits.
Development of coaxial-to-waveguide antenna attached outer GIS for detecting partial discharge

We have developed a coaxial-to-waveguide antenna that is capable of being attached to outer insulators in GIS. We firstly obtained the sensitivity line between output of the antenna (mV) and magnitude of partial discharge (pC) that is obtained based on IEC 60270. We also compared spectra measured by the coaxial-to-waveguide antenna from those measured by both spiral antenna and disc coupler so as to clarify frequency response and attenuation characteristics of the coaxial-to-waveguide antenna.
The Geoweb for community-based organizations: Tool development, implementation, and sustainability in an era of Google Maps

Recent advances in web-based geospatial tools (the Geoweb) show promise as low-cost and easy-to-use methods to support citizen participation. This research presents two case studies of Geoweb implementation set in community-based organizations in rural Quebec, Canada. When comparing the development and sustainability of each Geoweb tool, the implementation time frame plays a key role. Two implementation time frames are defined; a discrete, or ‘one-off’ time frame associated with lower resource requirements, and a continuous, or ongoing time frame, that has a higher total resource cost, but can fulfill a different set of goals than a discrete implementation.
Molecular Biology of von Willebrand Disease (vWD): A Study among Unrelated Pakistani Patients

2 Abstract: Von Willebrand Disease (vWD) is an autosomal dominant hereditary blood coagulation disorder that is highly variable in expression. Although the frequency of vWD is low in Pakistan but since the disease has similar manifestations as that of hemophilia A, some of the vWD patients are misdiagnosed. The molecular basis of vWD in Pakistan is also unknown. The main objective of this study is to identify the mutation that produces vWD in Pakistani patients and compare the ethnic differences. For this purpose the blood samples were collected from 11 unrelated vWD patients from southern Pakistan. DNA was extracted by using standard techniques. The DNA for only 15 exons was amplified. The reason for the selection of these exons was that most of mutations in these exons have been reported in South East Asian population. Sequencing results showed two point mutations were present within a same exon 28 in one vWD Sindhi patient, at codon 1229 and 1231 with changes GTT GGT and AAC ACC which results in the Asn Thr and Val Gly substitution respectively. These mutations have been previously reported in two separate individuals of different ethnic backgrounds. Four known SNPs in eight vWD patients were observed in exon 18, 20, 42. These SNPs are already been documented in other world populations. These results of mutational analysis on vWD patients are significant for the reason that this is the first study that has been carried out in Pakistan and it has provided some insight to molecular pathology of vWD in Pakistan which can be useful in conducting further studies. Also it can be helpful in the molecular diagnosis of vWD.
Comparison of information processing technologies.

OBJECTIVE To examine the type of information obtainable from scientific papers, using three different methods for the extraction, organization, and preparation of literature reviews. DESIGN A set of three review papers was identified, and the ideas represented by the authors of those papers were extracted. The 161 articles referenced in those three reviews were then analyzed using 1) a formalized data extraction approach, which uses a protocol-driven manual process to extract the variables, values, and statistical significance of the stated relationships; and 2) a computerized approach known as "Idea Analysis," which uses the abstracts of the original articles and processes them through a computer software program that reads the abstracts and organizes the ideas presented by the authors. The results were then compared. The literature focused on the human papillomavirus and its relationship to cervical cancer. RESULTS Idea Analysis was able to identify 68.9 percent of the ideas considered by the authors of the three review papers to be of importance in describing the association between human papillomavirus and cervical cancer. The formalized data extraction identified 27 percent of the authors' ideas. The combination of the two approaches identified 74.3 percent of the ideas considered important in the relationship between human papillomavirus and cervical cancer, as reported by the authors of the three review articles. CONCLUSION This research demonstrated that both a technically derived and a computer derived collection, categorization, and summarization of original articles and abstracts could provide a reliable, valid, and reproducible source of ideas duplicating, to a major degree, the ideas presented by subject specialists in review articles. As such, these tools may be useful to experts preparing literature reviews by eliminating many of the clerical-mechanical features associated with present-day scientific text processing.
Digital implementation of a two-way coherent phase transfer over optical fiber for remote clocks comparisons

We performed a two-way remote optical phase comparison on optical fiber. Two optical frequency signals were launched in opposite directions in an optical fiber and their phases were simultaneously measured at the other end. In this technique, the fiber noise is passively cancelled, and we compared two optical frequencies at the ultimate 10-21 stability level. The experiment was performed on a 47km fiber that is part of the metropolitan network for Internet traffic. The technique relies on the synchronous measurement of the optical phases at the two ends of the link, that is here performed by digital electronics. This scheme offers some advantages with respect to active noise cancellation schemes, as the light travels only once in the fiber.
Exposure to respirable silica among clay brick workers in Kathmandu valley, Nepal

ABSTRACT Previous studies report high respirable silica exposures among clay brick workers globally; however, there are little data on exposures among workers in fixed chimney Bull's trench kilns, the predominant kiln type in Kathmandu valley, Nepal. We investigated respirable silica exposures among workers (N = 46) in five similar exposure groups (SEGs). Mean exposures were highest for red brick loading/carrying (331 μg/m3), followed by green brick stacking (223 μg/m3), fireman (102 μg/m3), coal crushing/carrying (92 μg/m3), and green brick molding (71 μg/m3). The average free silica content (13.8%) in the respirable dust fraction was similar to levels reported for clay brick workers employed in other types of kilns. Dust control measures and respiratory protection are recommended, with priority given to workers assigned to red brick loading and stacking and green brick stacking and carrying.
Do Men and Women Respond Differently to Percutaneous Renal Artery Interventions?

Background: Women have higher risk of contrast-induced nephropathy than men. The purpose of this study was to determine the relative impact of gender on long-term renal function after percutaneous renal interventions (PRI). Methods and Results: We included all patients undergoing PRI. Men (n = 72) and women (n = 28) had similar age, men had more diabetes, coronary and peripheral artery disease, higher serum creatinine and similar glomerular filtration rate (GFR), and prevalence of chronic kidney disease (CKD) stage ≥3 when compared with females. At follow-up, men had a significant improvement in GFR and systolic blood pressure, while females did not. The presence of severe CKD and male gender were the only predictors of long-term GFR improvement. Conclusion: Male patients and patients with poor baseline renal function showed an important benefit with PRI, suggesting that it is not too late for renal revascularization if properly indicated.
Using Peptide-Level Proteomics Data for Detecting Differentially Expressed Proteins.

The expression of proteins can be quantified in high-throughput means using different types of mass spectrometers. In recent years, there have emerged label-free methods for determining protein abundance. Although the expression is initially measured at the peptide level, a common approach is to combine the peptide-level measurements into protein-level values before differential expression analysis. However, this simple combination is prone to inconsistencies between peptides and may lose valuable information. To this end, we introduce here a method for detecting differentially expressed proteins by combining peptide-level expression-change statistics. Using controlled spike-in experiments, we show that the approach of averaging peptide-level expression changes yields more accurate lists of differentially expressed proteins than does the conventional protein-level approach. This is particularly true when there are only few replicate samples or the differences between the sample groups are small. The proposed technique is implemented in the Bioconductor package PECA, and it can be downloaded from http://www.bioconductor. org.