Miracle-dz/UniFAR-FTUs huggingface dataset:
Physical health—a cluster randomized controlled lifestyle intervention among persons with a psychiatric disability and their staff

The objective was to explore the impact on physical health of a lifestyle programme among persons with psychiatric disabilities, and their caregivers. Their satisfaction with the intervention was also assessed. Somatic comorbidity and an increased mortality related to the lifestyle among persons with psychiatric disabilities are well known. Few randomized controlled trials have been aimed specifically at lifestyle issues among persons with a psychiatric disability. This trial includes clients with psychiatric disabilities living in supported housing and their staff. Forty-one persons with a DSM-? V diagnosis of severe mental illness from psychiatric disability from 10 supported housing facilities and 41 of their caregivers participated in this 12-month study during 2005–2006 in Sweden. The supported housing facilities with residents and staff were randomly assigned to either a health intervention programme or a control programme with an aesthetic content. The presence of metabolic syndrome and changes in the mean of physiological parameters such as Hba1c, P-glucose, P-insulin, lipids, blood pressure, physical working capacity, body mass index, Heart Score were investigated and participants’ satisfaction assessed. There was a significant reduction in the mean of metabolic syndrome criteria in the intervention group compared with the control group at the follow-up. The participants expressed satisfaction with the programme. The results indicate that health interventions on lifestyle issues when involving carers are appreciated, feasible and could be successful in reducing some health-related risk factors among persons with psychiatric disabilities.
In vivo leukocyte tropism of bovine leukemia virus in sheep and cattle

Bovine leukemia virus (BLV), an oncovirus related to human T-cell leukemia virus type I, causes a B-cell lymphoproliferative syndrome in cattle, leading to an inversion of the T-cell/B-cell ratio and, more rarely, to a B-cell lymphosarcoma. Sheep are highly sensitive to BLV experimental infection and develop B-cell pathologies similar to those in cattle in 90% of the cases. BLV tropism for B cells has been well documented, but the infection of other cell populations may also be involved in the BLV-induced lymphoproliferative syndrome. We thus looked for BLV provirus in other leukocyte populations in sheep and cattle by using PCR. We found that while B cells harbor the highest proviral load, CD8+ T cells, monocytes, and granulocytes, but not CD4+ T cells, also bear BLV provirus. As previously described, we found that persistent lymphocytosis in cows is characterized by an expansion of the CD5+ B-cell subpopulation but we did not confirm this observation in sheep in which the expanded B-cell population expressed the CD11b marker. Nevertheless, BLV could be detected both in bovine CD5+ and CD5- B cells and in sheep CD11b+ and CD11b- B cells, indicating that the restricted BLV tropism for a specific B-cell subpopulation cannot explain its expansion encountered in BLV infection. Altogether, this work shows that BLV tropism in leukocytes is wider than previously thought. These results lead the way to further studies of cellular interactions among B cells and other leukocytes that may intervene in the development of the lymphoproliferative syndrome induced by BLV infection.
The Construction of the Efficient Office: Scientific Management, Accountability, and the Neo‐Liberal State

The office has been a central site of organizational planning, accountability, and control since the 19th century. Yet it has been the subject of relatively little accounting research. Through the dual theoretical lenses of Foucaultian and Labour Process theories, this study employs historical photo‐elicitation methodology to investigate the implementation of management control and accountability in the scientifically managed office which emerged in the United States during the late 19th and early 20th centuries. Our analysis reveals the manner in which accounting records created new modes of disciplinary control and surveillance within the office and how accounting tasks were de‐skilled in a gradually feminized and mechanized office environment. We also witness the role of accounting in the physical structuring of office space through the assembly line arrangement of office furniture to facilitate paper flows and the installation of record‐keeping systems of surveillance. In addition, our visually derived historical account of these transformations in office administration allows us to reflect on some contemporary issues. The production‐line design and efficiency so promoted by scientific management served as a forerunner to today's open‐plan office, as well as influencing contemporary office management philosophies such as Activity‐Based Working. Furthermore, we seek to inform current debates on the role of accounting in contemporary neo‐liberal society. In the history of the scientific office, we gain an early glimpse of the subsequent role that accounting comes to play within a neo‐liberal agenda as a powerful technology of micro‐measurement and micro‐management.
A New Class and Order of Myxozoans to Accommodate Parasites of Bryozoans with Ultrastructural Observations on Tetracapsula bryosalmonae (PKX Organism)

Abstract Tetracapsula bryosalmonae, formerly PKX organism, is a myxozoan parasite that causes proliferative kidney disease in salmonid fish. Its primary hosts, in which it undergoes a sexual phase, are phylactolaemate bryozoans. It develops in the bryozoan coelomic cavity as freely floating sacs which contain two types of cells, stellate cells and sporoplasmogenic cells, which become organised as spores. Eight stellate cells differentiate as four capsulogenic cells and four valve cells which surround a single sporoplasmogenic cell. The sporoplasmogenic cell undergoes meiosis and cytoplasmic fission to produce two sporoplasms with haploid nuclei. Sporoplasms contain secondary cells. The unusual development supports previously obtained data from 18S rDNA sequences, indicating that species of Tetracapsula form a clade. It diverged early in the evolution of the Myxozoa, before the radiation that gave rise to the better known genera belonging to the two orders in the single class Myxosporea. The genus Tetracapsula as seen in bryozoans shares some of the characters unique to the myxosporean phase and others typical of the actinosporean phase of genera belonging to the class Myxosporea. However, it exhibits other features which are not found in either phase. A new class Malacosporea and order Malacovalvulida are proposed to accommodate the family Saccosporidae and genus Tetracapsula. Special features of the new class are the sac-like proliferative body, valve cells not covering the exit point of the polar filament, lack of a stopper-like structure sealing the exit, maintenance of valve cell integrity even at spore maturity, absence of hardened spore walls and unique structure of sporoplasmosomes in the sporoplasms.
Spatial Pattern of Residential Carbon Dioxide Emissions in a Rapidly Urbanizing Chinese City and Its Mismatch Effect

Cities undergoing rapid urbanization are characterized by quick successions of spatiotemporal patterns, meaning that traditional methods cannot adequately assess carbon emissions from urban residential areas, which prevents the study of spatial mismatch. Therefore, this study utilizes night-time lights to construct a spatial emissions model that enables the analysis of the evolution of emissions patterns in China. The results indicate that, compared to the traditional method, the spatial modeling based on night-time lights reflects the spatial emissions trajectories in a more timely and accurate manner in rapidly urbanizing cities. Additionally, we found a relatively low degree of spatial match between emissions and economic activities, with the former, which are greatly affected by urbanization, having a larger dynamism and instability than the latter. Such spatial mismatch effect illustrates that policy makers should focus on factors beyond economics in order to reduce residential carbon emissions during China’s rapid urbanization process.
Superparamagnetic Perfluorooctylbromide Nanoparticles as a Multimodal Contrast Agent for Us, Mr, and Ct Imaging

Background Multimodal contrast agents usually containing two or more signal components can be used for several imaging modalities. Thus, complimentary information can be obtained by using just one kind of contrast agents. Purpose To investigate the potential of superparamagnetic perfluorooctylbromide nanoparticles (M-PFOBNP) as a multimodal contrast agent for ultrasonography (US)/magnetic resonance (MR)/computed tomography (CT) multimodality imaging. Material and Methods The composite agent M-PFOBNP was developed by introducing superparamagnetic Fe3O4 nanoparticles into perfluorooctylbromide nanoparticles (PFOBNP). Several analytical tools were employed to characterize the agent. The potential of M-PFOBNP for US/MR/CT multimodality imaging were assessed in vivo. The cellular uptake and cytotoxicity of the agent were studied in vitro. Results M-PFOBNP with well-defined spherical morphology and homogeneous size of 200-250 nm was obtained. Fe3O4 nanoparticles were successfully integrated into PFOBNP and preserved their superparamagnetic characteristics after encapsulation. The in vivo studies showed that M-PFOBNP produced higher echogenicity than PFOBNP and possessed strong magnetic susceptibility and radiopacity for multimodality imaging. Macrophages incubated with different concentrations of M-PFOBNP resulted in a dose-dependent cellular uptake, which did not affect the viability of the cells. Conclusion M-PFOBNP may potentially serve as a multimodal contrast agent for enhanced US, MR, and CT imaging.
Hormonal and nutritional effects on cardiovascular risk markers in young women.

CONTEXT Cardiovascular (CV) risk markers, including high-sensitivity C-reactive protein (hsCRP), are increasingly important in predicting cardiac events. A favorable CV risk profile might be expected in anorexia nervosa (AN) due to low body weight and dietary fat intake. However, women with AN have decreased IGF-I levels reflecting decreased GH action, and IGF-I deficiency is associated with elevated hsCRP. Moreover, oral estrogens, known to increase hsCRP in other populations, are commonly prescribed in AN. To date, hsCRP levels and their physiological determinants have not been reported in women with AN. OBJECTIVE We examined the relationship between CV risk markers, undernutrition, IGF-I, and oral estrogens, specifically hypothesizing that in the setting of undernutrition, AN would be associated with low hsCRP despite low IGF-I levels and that those women taking oral contraceptive pills (OCPs) would have higher hsCRP and lower IGF-I levels. DESIGN AND SETTING We conducted a cross-sectional study at a clinical research center. STUDY PARTICIPANTS Subjects included 181 women: 140 women with AN [85 not receiving OCPs (AN-E) and 55 receiving OCPs (AN+E)] and 41 healthy controls [28 not receiving OCPs (HC-E) and 13 receiving OCPs (HC+E)]. MAIN OUTCOME MEASURES We assessed hsCRP, IL-6, IGF-I, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). RESULTS Despite low weight, more than 20% of AN+E had high-risk hsCRP levels. AN+E had higher hsCRP than AN-E. AN-E had lower mean hsCRP levels than healthy controls (HC+E and HC-E). IL-6 levels were higher in AN+E with elevated hsCRP (>3 mg/liter) than in AN+E with normal hsCRP levels. IGF-I was inversely associated with hsCRP in healthy women, suggesting a protective effect of GH on CV risk. However, this was not seen in AN. Few patients in any group had high-risk LDL or HDL levels. CONCLUSIONS Although hsCRP levels are lower in AN than healthy controls, OCP use puts such women at a greater than 20% chance of having hsCRP in the high-CV-risk (>3 mg/liter) category. The elevated mean IL-6 in women with AN and high-risk hsCRP levels suggests that increased systemic inflammation may underlie the hsCRP elevation in these patients. Although OCP use in AN was associated with slightly lower mean LDL and higher mean HDL, means were within the normal range, and few patients in any group had high-risk LDL or HDL levels. IGF-I levels appear to be important determinants of hsCRP in healthy young women. In contrast, IGF-I does not appear to mediate hsCRP levels in AN.
N4-Acyl-Modified D-2′,3′-Dideoxy-5-Fluorocytidine Nucleoside Analogues with Improved Antiviral Activity

A series of 2,3-dideoxy (D2) and 2,3-didehydro-2,3-dideoxy (D4) 5-fluorocytosine nucleosides modified with substituted benzoyl, heteroaromatic carbonyl, cycloalkylcarbonyl and alkanoyl at the N4-position were synthesized and evaluated for anti-human immunodeficiency virus type 1 (HIV-1) and anti-hepatitis B virus (HBV) activity in vitro. For most D2-nucleosides, N4-substitutions improved the anti-HIV-1 activity markedly without increasing the cytotoxicity. In the D4-nucleosides series, some of the substituents at the N4-position enhanced the anti-HIV-1 activity with a modest increase in the cytotoxicity. The most potent and selective N4-modified nucleoside for the D2-series was N4-p-iodobenzoyl-D2FC, which had a 46-fold increase in anti-HIV-1 potency in MT-2 cells compared to the parent nucleoside D-D2FC. In the D4-series, N4-p-bromobenzoyl-D4FC was 12-fold more potent in MT-2 cells compared to the parent nucleoside D-D4FC. All eight N4-p-halobenzoyl-substituted D2- and D4-nucleosides evaluated against HBV in HepAD38 cells demonstrated equal or greater potency than the two parental compounds, D-D2FC and D-D4FC. The N4-modification especially in the D2-nucleoside series containing the N4-nicotinoyl, o-nitrobenzoyl and n-butyryl showed a significant reduction in mitochondrial toxicity relative to the parent nucleoside analogue. Although the 5′-triphosphate of the parent compound (D-D4FC-TP) was formed from the N4-acyl-D4FC analogues in different cells, the levels of the 5′-triphosphate nucleotide did not correlate with the cell-derived 90% effective antiviral concentrations (EC90), suggesting that a direct interaction of the triphosphates of these N4-acyl nucleosides was involved in the antiviral activity.
Chronic kidney disease and automatic reporting of estimated glomerular filtration rate: a position statement

The systematic staging of chronic kidney disease (CKD) by glomerular filtration measurement and proteinuria has allowed the development of rational and appropriate management plans. One of the barriers to early detection of CKD is the lack of a precise, reliable and consistent measure of kidney function. The most common measure of kidney function is currently serum creatinine concentration. It varies with age, sex, muscle mass and diet, and interlaboratory variation between measurements is as high as 20%. The reference interval for serum creatinine concentration includes up to 25% of people (particularly thin, elderly women) who have an estimated glomerular filtration rate (eGFR) that is significantly reduced (< 60 mL/min/1.73m2). The recent publication of a validated formula (MDRD) to estimate GFR from age, sex, race and serum creatinine concentration, without any requirement for measures of body mass, allows pathology laboratories to “automatically” generate eGFR from data already acquired. Automatic laboratory reporting of eGFR calculated from serum creatinine measurements would help to identify asymptomatic kidney dysfunction at an earlier stage. eGFR correlates well with complications of CKD and an increased risk of adverse outcomes such as cardiovascular morbidity and mortality. We recommend that pathology laboratories automatically report eGFR each time a serum creatinine test is ordered in adults. As the accuracy of eGFR is suboptimal in patients with normal or near‐normal renal function, we recommend that calculated eGFRs above 60 mL/min/1.73m2 be reported by laboratories as “> 60 mL/min/1.73m2”, rather than as a precise figure.
History of demand side management and classification of demand response control schemes

The scope of this paper is to provide a review on the topic of demand side management. A historical overview provides a critical insight to applied cases, while the discovery of new evidence calls for reconsideration of the design of demand response control schemes. The developments at the demand side are analyzed, and philosophical considerations are made with respect to envisioned energy management systems. Finally, the authors classify demand response control schemes based on the formulation of the rate structures and the employed technology. This classification follows a historical order, and addresses both applied cases and research developments.
Skills needed by engineers in the platinum mining industry in South Africa

The South African platinum mining industry faces continuous challenges in terms of increased global competition, demand for productivity, skills shortages, loss of scarce technical skills due to emigration, strikes and high turnover rates. Hence, the lack of engineering skills (technical and management skills) may seriously hamper the capacity of the mining industry to ensure that productivity and safety standards are maintained. A quantitative study was conducted on skills needed by platinum mining engineers in three provinces in South Africa. A four-point Likert-type scale questionnaire ranging from strongly agree to strongly disagree was developed. The Cronbach's alpha coefficient was above 0.8, indicating high internal reliability. The population consisted of 300 engineers in platinum mines in three provinces in South Africa. A convenience sample was used; 79 engineers volunteered to complete the questionnaire. The response rate was 26.3%. A factor analysis was conducted to determine which skills of the engineers were the main concerns. The results of the study indicated that theoretical knowledge, technical skills, management skills and engineering principles were skills needed for technology-based engineering in the platinum mines under study.
Refined Mapping of a Hypertension Susceptibility Locus on Rat Chromosome 12

Previously, we found that transferring 6.1 Mb of salt-sensitive (SS) chromosome 12 (13.4–19.5 Mb) onto the consomic SS-12BN background significantly elevated mean arterial pressure in response to an 8% NaCl diet (178±7 versus 144±2 mm Hg; P<0.001). Using congenic mapping, we have now narrowed the blood pressure locus by 86% from a 6.1-Mb region containing 133 genes to an 830-kb region (chr12:14.36–15.19 Mb) with 14 genes. Compared with the SS-12BN consomic, the 830-kb blood pressure locus was associated with a &Dgr;+15 mm Hg (P<0.01) increase in blood pressure, which coincided with elevated albuminuria (&Dgr;+32 mg/d; P<0.001), proteinuria (&Dgr;+48 mg/d; P<0.01), protein casting (&Dgr;+154%; P<0.05), and renal fibrosis (&Dgr;+79%; P<0.05). Of the 14 genes residing in the 830-kb locus, 8 were differentially expressed, and among these, Chst12 (carbohydrate chondroitin 4 sulfotransferase 12) was most consistently downregulated by 2.6- to 4.5-fold (P<0.05) in both the renal medulla and cortex under normotensive and hypertensive conditions. Moreover, whole genome sequence analysis of overlapping blood pressure loci revealed an ≈86-kb region (chr12:14 541 567–14 627 442 bp) containing single-nucleotide variants near Chst12 that are unique to the hypertensive SS strain when compared with the normotensive Brown Norway, Dahl salt-resistant, and Wistar-Kyoto strains. Finally, the 830-kb interval is syntenic to a region on human chromosome 7 that has been genetically linked to blood pressure, suggesting that insight gained from our SS-12BN congenic strain may be translated to a better understanding of human hypertension.
Vertical, Horizontal and Residual Skills Mismatch in the Australian Graduate Labour Market

Studies of the Australian graduate labour market have found a substantial incidence of, and significant earnings effects from, vertical mismatch. This study extends the literature by examining horizontal mismatch, an important dimension of mismatch in its own right and which has been less studied. Over a quarter of Australian graduates are found to be mismatched, although the incidence is reduced in the longer term. Graduates from fields of study which are more occupation‐specific were found to be less likely to be mismatched. Earnings penalties were found for all forms of mismatch, and affected both general and specific fields of study.
Innovating for a cause: the work and learning required to create a new approach to healthcare for homeless people

Abstract Innovation occupies a pivotal place in our understanding of knowledge-based economies, and this is raising questions about sources of innovation, how it originates, and the role played by employees, work practices and learning. This paper explores these issues through case study research into a new approach to providing healthcare for homeless people in England, and by bringing together conceptual insights from the employee-driven innovation literature, and more broadly from social and practice-based learning theory and organisational theory. Applying these perspectives to our case enables illumination of the innovation as a process – not an event – and as an ongoing set of organisational practices that transcend their origins. Through our analysis we argue that the notion of ‘a cause’ is helpful in elucidating the impetus and the commitment to making the innovation happen (and go on happening). Our findings are presented under three themes: ‘establishing a cause’, ‘organising for innovation’, and ‘innovative capability in practice’. Building on these, we have identified five key inter-related dimensions which help conceptualise the work and learning that it took to create and (re-)enact the innovation and that we suggest may have relevance for understanding and characterising other employee-led innovations in and perhaps beyond healthcare.
Novel Field-Support Vector Regression-Based Soft Sensor for Accurate Estimation of Solar Irradiance

An accurate measurement of the solar irradiance is of significance for evaluating and developing of solar renewable energy systems. Soft sensors are used to provide feasible and economical alternatives to costly physical measurement instruments (e.g., pyranometers and pyrheliometers). Conventional soft-sensing methods assume that input data are identically and independently distributed (i.i.d.) and calculate an estimate of the solar irradiance via a regression model. However, different ambient temperatures result in various current–voltage characteristics, meaning that the i.i. d. assumption is violated. To improve the estimation accuracy, a field-support vector regression soft sensor is proposed to estimate the irradiance levels from photovoltaic (PV) electrical characteristics. The soft sensing system groups its input data into several fields in accordance with ambient temperatures. By transforming the original data into a style-free and i.i. d. space, the soft sensing model achieves better estimation performance. The proposed soft sensor can be easily implemented through a PV module, a thermometer, a current sensor, and a DSP development board. It is validated by simulations and experimental prototyping using real outdoor measurements.