Miracle-dz/UniFAR-FTUs huggingface dataset:
Ecological Momentary Assessment Using a Mobile Phone

The mobile phone has become a popular tool for providing information and capturing responses from different groups of people because of its technological features and portability. EMA (Ecological Momentary Assessment) is commonly used by health researchers to contemporaneously capture information regarding human experience. The authors proposed the use of a mobile EMA system as a supportive intervention to collect real-time patient data and to give back real-time advice. In this study, a mobile EMA system has been utilized by patients with a variety of conditions, including mood disorders, behavior disorders, and physical disorders. The real-time data collection included one or more pieces of information at each moment to improve understanding the causal mechanisms of disease. The effectiveness of real-time advice has been examined by comparing a mobile EMA system with and without this function. Patient compliance was high on average, at approximately 89%, and was higher, at approximately 93%, when advice was given. In several cases, the supportive intervention was shown to help patients improve their health conditions. However, the results were dependent on the patients’ motivation, environment, and relationship with their doctor. The EMA data regarding advice given showed that symptoms tended to improve in most cases. DOI: 10.4018/978-1-4666-2196-1.ch039
Schriftenreihe der Abteilung "Organisation und Technikgenese" des Forschungsschwerpunktes Technik-Arbeit-Umwelt am WZB FS II 97-112 The Live Case: A Method for Stimulating Individual, Group, and Organizational Learning

conceptualization Based on David Kolb (1984): Experiential Learning. Englewood Cliffs: New Jersey, p. 42 Kolb found correlations between career orientations and learning styles. For example, he observed that engineers tend to prefer learning approaches based on abstract conceptualization, whereas social workers more frequently emphasize the usefulness of active experimentation (Kolb, 1984:127). 4 Kolb, in turn, based his work on Kurt Lewin' s experiential learning model. See Kolb (1984:21).
Probing the Interaction between Nanoparticles and Lipid Membranes by Quartz Crystal Microbalance with Dissipation Monitoring

There is increasing interest in using quartz crystal microbalance with dissipation monitoring (QCM-D) to investigate the interaction of nanoparticles (NPs) with model surfaces. The high sensitivity, ease of use and the ability to monitor interactions in real-time has made it a popular technique for colloid chemists, biologists, bioengineers, and biophysicists. QCM-D has been recently used to probe the interaction of NPs with supported lipid bilayers (SLBs) as model cell membranes. The interaction of NPs with SLBs is highly influenced by the quality of the lipid bilayers. Unlike many surface sensitive techniques, by using QCM-D, the quality of SLBs can be assessed in real-time, hence QCM-D studies on SLB-NP interactions are less prone to the artifacts arising from bilayers that are not well formed. The ease of use and commercial availability of a wide range of sensor surfaces also have made QCM-D a versatile tool for studying NP interactions with lipid bilayers. In this review, we summarize the state-of-the-art on QCM-D based techniques for probing the interactions of NPs with lipid bilayers.
Hand and Mind: What Gestures Reveal About Thought.

The argument of this original and difficult book is that “gestures are an integral part of language as much as are words, phrases and sentences-gestures and language are one system” (p. 2) . Gestures are instantaneous, imagistic, analog, holistic expressions of the same thought that speech renders in hierarchical, linear, digital, analytic form. David McNeill credits Adam Kendon (1972, 1980) with discovering the link between, and essential unity of, speech sounds and gestural movements; his own work elaborates this insight at the higher linguistic levels of semantics and pragmatics. The topic of the book, then, is gestures that accompany speech, the left-hand end of what McNeill calls “ K e n h i ’ s coiitiiiiiiim: Gesticulation + Language-like gestures + Pantomimes 3 Emblems + Sign languages” (p. 37). The continuum ranges from the informal, spontaneous, idiosyncratic movements of the hands and arms that often accompany speech, to the socially-regulated, standardized, linguistic forms of a sign language, with its arbitrary (non-iconic) lexicon. Between these poles the obligatory presence of speech declines and the linguistic properties of gestures increase. “Language-like gestures” are grammatically integrated into an utterance, as when a speaker, asked about the weather on his vacation, replies: “Well, it was [oscillating hand gesture]”, where the “so-so” gesture replaces an adjectival predicate. “Pantomime” conveys its full meaning in silence or, at most, with inarticulate onomatopoeia; also, in pantomime, sequences of gestures can form a unit, as they can in a sign language, but cannot in gesticulation. “Emblems” conform to standards of wellformedness, a language-like property that gesticulation and pantomime lack: in England, the palm-front V-sign is Churchill’s “Victory! ”, the palm-back V-sign is a sexual insult. (For an amusing cross-class confusion in emblem dialects, see Collett, Marsh, and O’Shaughnessy, 1979, p. 229, where Margaret Thatcher appears in an Associated Press Photo, making the palm-back V-sign at a moment of electoral triumph.) The contrast between the two ends of Kendon’s continuum, between spontaneous gesture and conventional sign, epitomizes McNeill’s notion of the process by which an utterance evolves in a speaker’s mind. Spontaneous gesture reveals the primitive stage of an utterance, global, unsegmented, non-hierarchical, from which its conventional representation in speech unfolds: hierarchical, segmented, linear. The inner symbols of the primitive stage are private, idiosyncratic, closed to social influence; the end stage is public, grammatical, socially regulated. McNeill supposes that the primitive
Symplectic Floer-Donaldson theory and quantum cohomology

The goal of this paper is to give in outline a new proof of the fact that the Floer cohomology groups of the loop space of a semi-positive symplectic manifold (M; ! ) are naturally isomorphic to the ordinary cohomology of M. We shall then outline a proof that this isomorphism intertwines the quantum cup-product structure on the cohomology of M with the pair-of-pants product on Floer-homology. One of the key technical ingredients of the proof is a gluing theorem for J-holomorphic curves proved in 20]. In this paper we shall only sketch the proofs. Full details of the analysis will appear elsewhere.
Feature Selection at the Discrete Limit

Feature selection plays an important role in many machine learning and data mining applications. In this paper, we propose to use L2,p norm for feature selection with emphasis on small p. As p approaches 0, feature selection becomes discrete feature selection problem. We provide two algorithms, proximal gradient algorithm and rank one update algorithm, which is more efficient at large regularization. We provide closed form solutions of the proximal operator at p = 0, 1/2. Experiments onreal life datasets show that features selected at small p consistently outperform features selected at p = 1, the standard L2,1 approach and other popular feature selection methods.
WHUNlp at SemEval-2016 Task DiMSUM: A Pilot Study in Detecting Minimal Semantic Units and their Meanings using Supervised Models

This paper describes our approach towards the SemEval-2016 Task 10: Detecting Minimal Semantic Units and their Meanings (DiM-SUM). We consider that the two problems are similar to multiword expression detection and supersense tagging, respectively. The former problem is formalized as a sequence labeling problem solved by ﬁrst-order CRFs, and the latter one is formalized as a classiﬁcation problem solved by Maximum Entropy Algorithm. To carry out our pilot study quickly, we extract some simple features such as words or part-of-speech tags from the training set, and avoid using external resources such as Word-Net or Brown clusters which are allowed in the supervised closed condition. Experimental re-sults show that much further work on feature engineering and model optimization needs to be explored.
Jagged1 Is Altered in Alzheimer's Disease and Regulates Spatial Memory Processing

Notch signaling plays an instrumental role in hippocampus-dependent memory formation and recent evidence indicates a displacement of Notch1 and a reduction its activity in hippocampal and cortical neurons from Alzheimer's disease (AD) patients. As Notch activation depends on ligand availability, we investigated whether Jagged1 expression was altered in brain specimen of AD patients. We found that Jagged1 expression was reduced in the CA fields and that there was a gradual reduction of Jagged1 in the cerebrospinal fluid (CSF) with the progression of dementia. Given the role of Notch signaling in memory encoding, we investigated whether targeted loss of Jagged1 in neurons may be responsible for the memory loss seen in AD patients. Using a transgenic mouse model, we show that the targeted loss of Jagged1 expression during adulthood is sufficient to cause spatial memory loss and a reduction in exploration-dependent Notch activation. We also show that Jagged1 is selectively enriched at the presynaptic terminals in mice. Overall, the present data emphasizes the role of the Notch ligand, Jagged1, in memory formation and the potential deficit of the signaling ligand in AD patients.
Model Predictive Control for urban traffic networks via MILP

Model Predictive Control (MPC) is an advanced control strategy that can easily coordinate urban traffic networks. But, due to the nonlinearity of the traffic model, the optimization problem of the MPC controller will become intractable in practice when the scale of the controlled traffic network grows larger. To solve this problem, the nonlinear traffic model is reformulated into a model with only linear equations and inequalities. Mixed-Integer Linear Programming (MILP) algorithms can efficiently solve the reformulated optimization problem, and guarantee the global optimum at the same time. Moreover, the MILP optimization problem is further relaxed by model reduction and adding upper bound constraints.
Finding hidden Borel subgroups of the general linear group

We present a quantum algorithm for solving the hidden subgroup problem in the general linear group over a finite field where the hidden subgroup is promised to be a conjugate of the group of the invertible lower triangular matrices. The complexity of the algorithm is polynomial when size of the base field is not much smaller than the degree.
ACUTE RESPIRATORY DISTRESS INDUCED BY REPEATED SALINE LAVAGE PROVIDES STABLE EXPERIMENTAL CONDITIONS FOR 24 HOURS IN PIGS

Surfactant depletion is most often used to study acute respiratory failure in animal models. Because model stability is often criticized, the authors tested the following hypotheses: Repeated pulmonary lavage with normal saline provides stable experimental conditions for 24 hours with a PaO2/FiO2 ratio < 300 mm Hg. Lung injury was induced by bilateral pulmonary lavages in 8 female pigs (51.5 ± 4.8 kg). The animals were ventilated for 24 hours (PEEP: 5 cm H2O; tidal volume: 6 mL/kg; respiratory rate: 30/min). After 24 hours the animals were euthanized. For histopathology slides from all pulmonary lobes were obtained. Supernatant of the bronchoalveolar fluid collected before induction of acute respiratory distress syndrome (ARDS) and after 24 hours was analyzed. A total of 19 ± 6 lavages were needed to induce ARDS. PaO2/FiO2 ratio and pulmonary shunt fraction remained significantly deteriorated compared to baseline values after 24 hours (P <. 01). Slight to moderate histopathologic changes were detected. Significant increases of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 were observed after 24 hours (P <. 01). The presented surfactant depletion–based lung injury model was associated with increased pulmonary inflammation and fulfilled the criteria of acute ling injury (ALI) for 24 hours.
Aberrant methylation of LINE-1, SLIT2, MAL and IGFBP7 in non-small cell lung cancer

Genome-wide DNA hypomethylation and gene hypermethylation play important roles in instability and carcinogenesis. Methylation in long interspersed nucleotide element 1 (LINE-1) is a good indicator of the global DNA methylation level within a cell. Slit homolog 2 (SLIT2), myelin and lymphocyte protein gene (MAL) and insulin-like growth factor binding protein 7 (IGFBP7) are known to be hypermethylated in various malignancies. The aim of the present study was to assess the precise methylation levels of LINE-1, SLIT2, MAL and IGFBP7 in non-small cell lung cancer (NSCLC) using a pyrosequencing assay. Methylation of all regions was examined in 56 primary NSCLCs using a pyrosequencing assay. Changes in mRNA expression levels of SLIT2, MAL and IGFBP7 were measured before and after treatment with a demethylating agent. Methylation of these genes was also examined in 9 lung cancer cell lines using RT-PCR and a pyrosequencing assay. Frequencies of hypomethylation of LINE-1 and hypermethylation of SLIT2, MAL and IGFBP7, defined by predetermined cut off values, were 55, 64, 46 and 54% in NSCLCs, respectively and exhibited tumor-specific features. The hypermethylation of all genes was well correlated with changes in expression. The methylation level and frequency of MAL were significantly higher in smokers and in patients without EGFR mutations. Through accurate measurement of methylation levels using pyrosequencing, hypomethylation of LINE-1 and hypermethylation of SLIT2, MAL and IGFBP7 were frequently detected in NSCLCs and associated with various clinical features. Analysis of the methylation profiles of these genes may, therefore, provide novel opportunities for the therapy of NSCLCs.
Secret key generation in correlated multi-dimensional Gaussian channels

Wireless channel reciprocity can be successfully exploited as a common source of randomness for the generation of a secret key by two legitimate users willing to achieve confidential communications over a public channel. This paper presents an analytical framework to investigate the theoretical limits of secret-key generation when wireless multi-dimensional Gaussian channels are used as source of randomness. The intrinsic secrecy content of wide-sense stationary wireless channels in frequency, time and spatial domains is derived through asymptotic analysis as the number of observations in a given domain tends to infinity. Some significant case studies are presented where single and multiple antenna eavesdroppers are considered. In the numerical results, the role of signal-to-noise ratio, spatial correlation, frequency and time selectivity is investigated.
Using an Iconic Language to Improve Access to Electronic Medical Records in General Medicine

Physicians have difficulties to access and analyse information in a medical record. In a previous work on drug databanks, we have shown that with an iconic language as VCM, an icon-based presentation can help physicians to access medical information. Our objective, herein, is to study whether VCM can be used in an electronic medical record for facilitating physician access in general practice. We identify the data and the functionalities of an electronic medical record that could benefit from VCM icons representing clinical findings, patient history, etc. We also present a preliminary evaluation of this new icon-focused interface. We conclude by discussing the results like the assessment of the user's satisfaction and pointing out the importance of coding data.
FAST AXOPLASMIC TRANSPORT OF ACETYLCHOLINESTERASE IN MAMMALIAN NERVE FIBRES

Abstract— Acetylcholinesterase (acetylcholine acetyl‐hydrolase, EC 3.1.1.7) is carried down mammalian nerve fibres by the fast axoplasmic transport system. This conclusion was derived from experiments involving the ligation of cat sciatic nerves at two sites placed 83.5 mm apart. The enzyme accumulated in segments of nerve proximal to the upper ligation in a linear fashion over a period of at least 20 h. At approximately 5 h the accumulation of enzyme ceased in the nerve segment proximal to the distal ligation within the isolated length of nerve, an observation indicating that the portion of AChE free to move within the isolated nerve had been depleted during this period of time. The freely moving fraction of AChE was estimated to be 15% of the total enzyme activity present in the nerve (10% in the proximo‐distal direction and 5% in the retrograde direction). The rate of AChE downflow (as estimated from the intercept of the curve plotting accumulation with the line denoting when depletion started) was 431 mm/day within a 95% confidence interval of 357–543 mm/day. In view of the variability, our results demonstrated that AChE was being carried by the fast axoplasmic transport system, which in earlier studies was estimated to have a characteristic rate close to 410 mm/day.
MOLECULAR COMPARISON OF WILD AND COMMERCIAL CHILIES FROM TAMAULIPAS AND TABASCO, MEXICO

The genetic differences among two groups of varieties of chili (Capsicum spp.) from different geographical origins (one each from the states of Tabasco and Tamaulipas in the Mexican republic) were studied using AFLP (Amplified Fragment Length Polymorphism) molecular markers. Four Tabasco chili varieties were studied; two cultivars (Jalapeno, Habanero) that belong to Caspicum annuum L. and Capsicum chinense Jacq. , respectively and two wild varieties (Amashito, Ojo de cangrejo), that belong to Capsicum annuum var. glabriusculum. Five Tamaulipas chili varieties were studied: the Mirador, Piquin huasteco and Ozulamero varieties, which belong to Capsicum annuum L, and the Pico paloma and Chilpaya tabasco varieties, which belong to Capsicum frutescens. For the analysis of genetic differentiation, four AFLP molecular markers were used, which amplified 150 to 209 bands in the two variety groups. The AMOVA (Analysis of molecular variance) results indicated that the maximum variation was found between the regions (37.0%) and within the populations of each region (37.0%). The estimated variety differentiation was high, FST=0.373, which indicates that 62.70% from the variation is found within the varieties, and the high values of FIS=0.409 and FIT= 0.629 lead to the assumption that the varieties possess a large number of homozygotes and a substantial loss of heterozygotes. The cluster analysis separated the evaluated varieties by geographical region and by kind; for Tabasco, the wild Amashito and the Ojo de cangrejo were grouped, and the cultivated varieties formed their own group. In the Tamaulipas varieties, this grouping tendency was not observed.
A randomised controlled trial of computer-assisted interviewing in sexual health clinics

Objectives To assess the impact of computer-assisted interview compared with pen and paper on disclosure of sexual behaviour, diagnostic testing by clinicians, infections diagnosed and referral for counselling. Methods Two-centre parallel three-arm randomised controlled open trial. Computer-generated randomisation with allocation concealment using sealed envelopes. Setting Two London teaching hospital sexual health clinics. Participants 2351 clinic attenders over the age of 16 years. Interventions Computer-assisted self-interview (CASI). Computer-assisted personal interview (CAPI). Pen and paper interview (PAPI). Main Outcome Measures Diagnostic tests ordered, sexually transmitted infections (STI). Secondary Outcomes Disclosure of sexual risk, referral for counselling. Results 801, 763 and 787 patients randomly allocated to receive CASI, CAPI and PAPI. 795, 744 and 779 were available for intention-to-treat analysis. Significantly more diagnostic testing for hepatitis B and C and rectal samples in the CAPI arm (odds for more testing relative to PAPI 1.32; 95% CI 1.09 to 1.59). This pattern was not seen among CASI patients. HIV testing was significantly lower among CASI patients (odds for less testing relative to PAPI 0.73; 95% CI 0.59 to 0.90). STI diagnoses were not significantly different by trial arm. A summary measure of seven prespecified sensitive behaviours found greater reporting with CASI (OR 1.4; 95% CI 1.2 to 1.6) and CAPI (OR 1.4; 95% CI 1.2 to 1.7) compared with PAPI. Conclusion CASI and CAPI can generate greater recording of risky behaviour than traditional PAPI. Increased disclosure did not increase STI diagnoses. Safeguards may be needed to ensure that clinicians are prompted to act upon disclosures made during self-interview. Trial registration ISRCTN: 97674664.
Different proteolipid protein mutants exhibit unique metabolic defects

PMD (Pelizaeus–Merzbacher disease), a CNS (central nervous system) disease characterized by shortened lifespan and severe neural dysfunction, is caused by mutations of the PLP1 (X-linked myelin proteolipid protein) gene. The majority of human PLP1 mutations are caused by duplications; almost all others are caused by missense mutations. The cellular events leading to the phenotype are unknown. The same mutations in non-humans make them ideal models to study the mechanisms that cause neurological sequelae. In the present study we show that mice with Plp1 duplications (Plp1tg) have major mitochondrial deficits with a 50% reduction in ATP, a drastically reduced mitochondrial membrane potential and increased numbers of mitochondria. In contrast, the jp (jimpy) mouse with a Plp1 missense mutation exhibits normal mitochondrial function. We show that PLP in the Plp1tg mice and in Plp1-transfected cells is targeted to mitochondria. PLP has motifs permissive for insertion into mitochondria and deletions near its N-terminus prevent its co-localization to mitochondria. These novel data show that Plp1 missense mutations and duplications of the native Plp1 gene initiate uniquely different cellular responses.
TAO: how facebook serves the social graph

Over 800 million people around the world share their social interactions with friends on Facebook, providing a rich body of information referred to as the social graph. In this talk, I describe how we model and serve this graph. Our model uses typed nodes (fbobjects) and edges (associations) to express the relationships and actions that happen on Facebook. We access the graph via a simple API that provides queries over the set of same-typed associations leaving an object. We have found this API to be both sufficiently expressive and amenable to a scalable implementation. In the last segment of the talk I describe the design of TAO, our graph data store. TAO is a distributed implementation of the fbobject and association API that has been serving production traffic at Facebook for more than 2 years.