Miracle-dz/UniFAR-FTUs huggingface dataset:
SARCOMAS OF THE UPPER EXTREMITY IN CHILDREN

Bone and soft tissue sarcomas of the upper extremities in children are rare, but the practicing pediatric orthopaedist should be aware of their presentation, biology and treatment. This report presents a brief review of the presentation, diagnostic findings and treatment of osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, synovial sarcoma and infantile fibrosarcoma of the upper extremity in the pediatric population.
The PRP4 (RNA4) protein of Saccharomyces cerevisiae is associated with the 5' portion of the U4 small nuclear RNA

We have combined oligonucleotide-directed RNase H degradation and immunoprecipitation in a study of the association of the Saccharomyces cerevisiae PRP4 protein with the U4-U6 complex. We have found that three oligonucleotides were able to direct nearly to completion the RNase H-specific cleavage of the target RNA molecules as they exist in splicing extracts. Immunoprecipitation of the degradation products with PRP4 antibody showed that the 5' portion of U4 small nuclear RNA (snRNA) and the 3' portion of U6 snRNA coimmunoprecipitated with the PRP4 protein. Micrococcal nuclease protection experiments confirmed further that the 5' portion and 3' end of U4 snRNA were very resistant to nuclease digestion, whereas the 3' portion of U6 snRNA was protected to only a very small extent. We conclude that the PRP4 protein of S. cerevisiae is associated primarily with the 5' portion of U4 snRNA in the U4-U6 small nuclear ribonucleoprotein (snRNP).
Ethnomethodology: A Critical Review

The paper reviews recent publications in ethnomethodology (EM) from sympathetic but critical perspective. It is agreed that EM has made major contributions to sociological theory and to the empirical investigation of everyday life. A number of major reservations are made, however. The author suggests that some contemporary versions of EM—conversation analysis in particular—have an unduly restricted perspective. They give rise to a sociology which is behaviorist and empiricist, and which does not reflect the interpretative origins that inspired EM. Far from being a coherent and homogenous movement, the author suggests, EM is marked by inconsistency.
Risk Factors Associated With the Transition From Acute to Chronic Occupational Back Pain

Study Design. A prospective cohort study was conducted on workers claiming earnings-related compensation for low back pain. Information obtained at the time of the initial claim was linked to compensation status (still claiming or not claiming) 3 months later. Objective. To identify individual, psychosocial, and workplace risk factors associated with the transition from acute to chronic occupational back pain. Summary of Background Data. Despite the magnitude of the economic and social costs associated with chronic occupational back pain, few prospective studies have investigated risk factors identifiable in the acute stage. Methods. At the time of the initial compensation claim, a self-administered questionnaire was used to gather information on a wide range of risk factors. Then 3 months later, chronicity was determined from claimants’ computerized records. Results. The findings showed that 3 months after the initial assessment, 204 of the recruited 854 claimants (23.9%) still were receiving compensation payments. A combined multiple regression model of individual, psychosocial, and workplace risk factors demonstrated that severe leg pain (odds ratio [OR], 1.9), obesity (OR, 1.7), all three Oswestry Disability Index categories above minimal disability (OR, 3.1–4), a General Health Questionnaire score of at least 6 (OR, 1.9), unavailability of light duties on return to work (OR, 1.7), and a job requirement of lifting for three fourths of the day or more all were significant, independent determinants of chronicity (P < 0.05). Conclusions. Simple self-report measures of individual, psychosocial, and workplace factors administered when earnings-related compensation for back pain is claimed initially can identify individuals with increased odds for development of chronic occupational disability.
Genetic analysis of the chromosome segregation protein Spo0J of Bacillus subtilis: evidence for separate domains involved in DNA binding and interactions with Soj protein

Spo0J and Soj belong to the ParB/ParA family of proteins involved in chromosome and plasmid segregation in bacteria. In Bacillus subtilis, Spo0J protein binds to several specific sites, parS, located on both sides of the origin of DNA replication, oriC, and apparently self‐associates to form large discrete foci visible by fluorescence microscopy. Soj protein forms large ‘patches’ probably associated with the nucleoid, which can undergo dynamic, co‐operative jumping from nucleoid to nucleoid in the presence of Spo0J. Patches of Soj protein somehow help to bring about the condensation of Spo0J foci. Soj is also a negative regulator of transcription. In the absence of Spo0J, Soj is statically distributed on each of the nucleoids in the cell and blocks the transcription of several sporulation genes. To analyse the functional interaction between Spo0J and Soj further, we have constructed and studied a collection of spo0J mutants. Most of the mutants completely prevent Spo0J from interacting with DNA. One mutation impairs the formation of compact Spo0J foci and simultaneously results in loss of Soj movement. We also isolated one spo0J mutant, in which the frequency of Soj internucleoid oscillation is highly increased. Both mutations affecting the interaction with Soj lie in the N‐terminal coding part of spo0J, whereas the substitutions affecting DNA binding lie in the mid‐ to C‐terminal coding region.
Storage selection for DG applications containing virtual synchronous generators

The paper is presenting an algorithm for establishing the best types of electrical storages for the virtual synchronous generator (VSG), depending on the application case and desired nominal power of the VSG. The resulting application provides a description of available technologies in terms of characteristics matching the desired properties of the storage in accordance with the scenarios described by the user.
Distinct protein forms are produced from alternatively spliced bicistronic glutamic acid decarboxylase mRNAs during development

It has been shown that the enzyme glutamic acid decarboxylase (GAD; EC 4.1.1.15), which catalyzes the conversion of L-glutamate to gamma-aminobutyric acid in the central nervous system of vertebrates, can be first detected in rodents at late embryonic stages. In contrast, we have found that the gene coding for the 67-kDa form of GAD is already transcriptionally active at embryonic day E10.5 in the mouse. In addition to the 3.5-kb adult-type mRNA, we have detected two 2-kb embryonic messages that contain alternatively spliced exons of 80 (I-80) and 86 (I-86) bp, respectively. The overlapping stop-start codon TGATG, found in the embryonic exons, converts the monocistronic adult-type transcript into a bicistronic one, coding for a 25-kDa leader peptide and a 44-kDa enzymatically active truncated GAD. A second stop codon at the 3' end of the 86-bp exon abolishes the expression of truncated GAD. The products of the two embryonic mRNAs were identified in a rabbit reticulocyte in vitro translation system, COS cells, and mouse embryos. The two GAD embryonic forms represent distinct functional domains and display characteristic developmental patterns, consistent with a possible role in the formation of the gamma-aminobutyric acid-ergic inhibitory synapses.
Frequency of dividing cells and viability of Microcystis aeruginosa in sediment of a eutrophic reservoir

Blooms of Microcystis aeruginosa occurred in summer months for several years in the reservoir of Grangent (France). Disappearance of planktonic colonies in autumn does not necessarily mean the end of the life cycle for cyanobacteria, and part of them sink down to the sediment. Frequency of dividing cells (FDC) of benthic M. aeruginosa was measured under experimental hypolimnetic conditions in winter and in spring (darkness and temperature = 4 or 8°C) to show overwintering survival and difference between seasons. Enzymatic activity (viability) of benthic cyanobacteria was controlled in situ in winter and spring. Our study revealed that in winter (4°C), benthic colonies continued to divide, with low FDC (mean % = 13.49) and low enzymatic activity (mean ratio carboxyfluorescein diacetate (CFDA) fluorescence:autofluorescence = 1.27). In contrast, when temperature increased in spring (8°C), the viability values significantly increased (mean ratio = 3.78), and a rhythmic increase of FDC appeared every 8 h with maximum of ca. 27.5%. This corre- sponds to an ultradian rhythm of division, which provides strong evidence that benthic cells were under the control of an endogenous component synchronized by an internal clock. Our results suggest that hypolimnetic temperature plays an important role in the return of the active form of M. aeruginosa in spring.
False perception of visual verticality in multiple sclerosis

We wanted to investigate to what extent patients with multiple sclerosis (MS), not complaining of dizziness or disequilibrium, may have problems with the estimation of gravidity. Therefore, we studied the static ‘subjective visual vertical’ (SVV), a test that is thought to reflect mainly otolith function. Further, we correlated SVV measures with the degree of disease disability. A group of outpatients was compared with a group of age‐ and sex‐matched healthy volunteers. The deviations of SVV in patients were significantly larger than in controls. Overall, SVV was abnormal in 48% of individual patients. There was a significant correlation between SVV and the global disability score. The same held true for correlation with the subscores of brainstem and cerebellar complaints. The SVV test proved to be a simple method that was well tolerated by the patients. It can be considered a complementary otoneurological tool for evaluating MS patients. Further, these findings suggest that misperception of the verticality parallels the disability in MS patients.
Characterization and Molecular Mapping of a Soft Glume Mutant in Diploid Wheat (Triticum monococcum L.)

Diploid wheat T. monococcum L. is a model plant for wheat functional genomics. A soft glume mutant was identified during manual screening of EMS-treated M2 progenies of a T. monococcum accession pau14087. The seeds in the mature spike of the mutant could be easily threshed manually. The soft glume mutant with high sterility, tapering and broader spikes had also tougher rachis than the wild type parent. Genetic analysis of crosses of the mutant with wild type indicated that the mutant was monogenic recessive. To map the soft glume mutant, a mapping population was developed by crossing the soft glume mutant with wild Triticum boeoticum acc. pau 5088, having tough glumes and hard threshing. The soft glume mutant was mapped between SSR markers Xgwm473 and Xbarc69 on 7AmL chromosome of T. monococcum, with a genetic distance of 1.8 cM and 8.3 cM, respectively. The soft glum mutant mapped on 7AmL, being distinct from a previously mapped soft glume mutant in wheat, has been designated as sog2. The work on fine ma.
A parallel architectural implementation of the fast three step search algorithm for block motion estimation

This paper proposes a parallel architecture for a fast three step search (FTSS) algorithm, which is used in motion estimation. FTSS algorithm involves reduced number of search points and is thus less computationally expensive compared to the standard three step search (TSS) algorithm. Degradation of performance while applying the FTSS algorithm to several standard images has been shown to be insignificant compared to the standard TSS algorithm. The proposed architecture uses only three processing elements accompanied with use of intelligent data arrangement and memory configuration. A technique for reducing external memory accesses has also been developed. The proposed architecture for FTSS provides an efficient solution for applications requiring real-time motion estimations, because it requires smaller area and power than what would be required to implement TSS. The proposed architecture provides the solution for low bit-rate video applications like video telephony and teleconferencing.
The Development of a Mobile Agent Platform

This paper describes the software engineering process used in the development of the Crossbow2 agent platform. Crossbow2 is a light-weight agent platform that enables the basic agent functionalities: agent creation, migration, detection, communication and destruction. The platform was developed with the extreme programming (XP) approach. The paper elaborates the activities included in the software development process and the XP practices used in the requirement specification, system design, implementation and testing
Error Analysis, Design and Modeling of an Improved Heterodyne Nano-Displacement Interferometer

A new heterodyne nano-displacement with error reduction is presented. The main errors affecting the displacement accuracy of the nano-displacement measurement system including intermodulation distortion error, cross-talk error, cross-polarization error and phase detection error are calculated. In the designed system, a He-Ne laser having three-longitudinal-mode is considered as the stabilized source. The free spectral range of the 35cm laser cavity is about 435-MHz at 632.8-nm wavelength, which a secondary beat frequency equal to 300-kHz is produced by combining the reference and measurement beams. The resolution of the displacement measurement resulting from intermodulation distortion, cross-talk and cross-polarization errors is limited to 18-pm. Also, the phase detection uncertainty causes an error of only 5.9-pm in the displacement measurement. Furthermore, frequency-path models of two- and three-longitudinal-mode laser interferometers are modeled as the ac interference, ac reference, dc interference and optical power terms. A comparison study between two- and three-longitudinal-mode laser interferometers confirms that the performance of the designed system is considerably improved.
Phase-only signal reconstruction

In this paper, we develop a set of conditions under which a sequence is uniquely specified by the phase or samples of the phase of its Fourier transform. These conditions are applicable to mixed-phase one-dimensional and multi-dimensional sequences. Under the specified conditions, we also present several algorithms which may be used to reconstruct a sequence from its phase.
Diagnosis of Choroidal Melanoma in Dense Asteroid Hyalosis

ABSTRACT Purpose: To demonstrate the utility of Optos ultra-wide field imaging in the diagnosis and management of choroidal melanoma in the setting of asteroid hyalosis. Design: Observational case report. Method: A 52-year-old female was referred for evaluation of floaters, photopsias, and blurry vision in the right eye. Clinical examination revealed dense asteroid hyalosis obscuring the fundus, and a limited view of a pigmented choroidal lesion in the nasal periphery. Optos ultra-wide field fluorescein angiography and ultrasonography facilitated the diagnosis of a choroidal melanoma. Results: The patient underwent Iodine-125 brachytherapy for local tumor control and excellent tumor response was confirmed with serial follow-up Optos imaging and ultrasonography. Conclusion: Ultra-wide field fundus fluorescein angiography facilitated the diagnosis of a choroidal melanoma, which was obscured by dense asteroid hyalosis, allowing for local tumor control with brachytherapy. Optos wide-field imaging may be a valuable tool for detecting potentially life-threatening lesions in the setting of asteroid hyalosis.
Radio and gamma-ray properties of extragalactic jets from the TANAMI sample

The TANAMI program has been observing parsec-scale radio jets of southern (declination south of − 30°) γ -ray bright AGN, simultaneously with Fermi /LAT monitoring of their γ -ray emission, via high-resolution radio imaging with Very Long Baseline Interferometry techniques. We present the radio and γ -rayproperties of the TANAMI sources based on one year of contemporaneous TANAMI and Fermi /LAT data. A large fraction (72%) of the TANAMI sample can be associated with bright γ -ray sources for this time range. Association rates differ for different optical classes with all BL Lacs, 76% of quasars, and just 17% of galaxies detected by the LAT. Upper limits were established on the γ -ray flux from TANAMI sources not detected by LAT. This analysis led to the identification of three new Fermi sources whose detection was later confirmed. The γ -ray and radio luminosities are related by L γ ∝ L r 0.89±0.04 . The brightness temperatures of the radio cores increase with the average γ -ray luminosity and the presence of brightness temperatures above the inverse Compton limit implies strong Doppler boosting in those sources. The undetected sources have lower γ /radio luminosity ratios and lower contemporaneous brightness temperatures. Unless the Fermi /LAT-undetected blazars are much γ -ray-fainter than the Fermi /LAT-detected sources, their γ -ray luminosity should not be significantly lower than the upper limits calculated here.
Model Predictive Control of a Nonlinear 2-Body Point Absorber Wave Energy Converter With Estimated State Feedback

Ocean wave energy has the potential to significantly contribute to sustainable power generation in coastal regions. Much of the research effort has gone into developing time domain state space models of point absorber wave energy converters (WECs) and subsequently into model-based optimal control to efficiently harvest the maximum possible amount of energy. The resulting controllers require knowledge of the states of the WEC in order to achieve the design goals. The purpose of this paper is to design and apply an extended Kalman filter-based estimation algorithm to a nonlinear two-body WEC model and to evaluate its performance in conjunction with a model predictive controller (MPC), which maximizes energy yield while satisfying operational constraints.
Bisphenol A and Chronic Disease Risk Factors in US Children

OBJECTIVE: To evaluate the relationship between urinary bisphenol A (BPA) levels and measures of adiposity and chronic disease risk factors for a nationally representative US pediatric sample. METHODS: We used the NHANES 2003–2010 to evaluate cross-sectional associations between urinary BPA and multiple measures of adiposity, cholesterol, insulin, and glucose for children aged 6 to 18 years, adjusting for relevant covariates (eg, demographics, urine creatinine, tobacco exposure, and soda consumption). RESULTS: We found a higher odds of obesity (BMI ≥95th percentile) with increasing quartiles of BPA for quartiles 2 vs 1 (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.17–2.60, P = .008), 3 vs 1 (OR 1.64, 95% CI 1.09–2.47, P = .02), and 4 vs 1 (OR 2.01, 95% CI 1.36–2.98, P = .001). We also found a higher odds of having an abnormal waist circumference–to–height ratio (quartiles 2 vs 1 [OR 1.37, 95% CI 0.98–1.93, P = .07], 3 vs 1 [OR 1.41, 95% CI 1.07–1.87, P = .02], and 4 vs 1 [OR 1.55, 95% CI 1.12–2.15, P = .01]). We did not find significant associations of BPA with any other chronic disease risk factors. CONCLUSIONS: Higher levels of urinary BPA were associated with a higher odds of obesity (BMI >95%) and abnormal waist circumference–to–height ratio. Longitudinal analyses are needed to elucidate temporal relationships between BPA exposure and the development of obesity and chronic disease risk factors in children.
Generic antiepileptic drugs and associated medical resource utilization in the United States

GENERIC ANTIEPILEPTIC DRUGS AND ASSOCIATED MEDICAL RESOURCE UTILIZATION IN THE UNITED STATES To the Editor: Labiner et al.1 investigated the differences in medical source utilization by patients using generic substitutions for 5 commonly prescribed antiepileptic drugs (AEDs) in the United States. Using health insurance claims information from PharMetrics database, the authors concluded that generic AED use led to significantly greater utilization of medical resources and risk of epilepsy-related adverse events compared to brand use. Their unblinded study has some design limitations, which may have affected the conclusions. Many of these limitations are mentioned in the article and the accompanying editorial by Dr. Besag.2 Many neurologists consider that the thrust to use brand-name drugs—even for conditions that have a narrow therapeutic index such as epilepsy—is predominantly industry-driven. Physicians are consistently reminded by industry representatives through studies like this that generics are somehow less potent than brandname drugs and that seizure control frequently deteriorates when a patient is switched to a generic. My experience points to the contrary. The majority of patients who are switched to a generic AED either due to treating physician or patient preference experience no change in their seizure frequency or side-effect profile. There is no change in the frequency of outpatient visits or of utilization of emergency services, including the emergency department. Generic versions have to meet the same Food and Drug Administration (FDA) standards of bioequivalence as the brand-name medication. In addition, there is no scientific evidence demonstrating that generics are inferior in quality. Generic versions play an important role by providing essential drugs at an affordable price, thus reducing overall health care costs. This article is industry-supported and the authors’ personal disclosure statements indicate a financial relationship with the study sponsor. Some of the authors published a similar study commenting on the risks and costs of multiple-generic substitutions of topiramate.3 That study also derided generics. I agree with Dr. Besag’s editorial.2 It is time for journals to stop publishing open studies sponsored by the pharmaceutical industry and concentrate on publishing rigorous scientific studies to settle this contentious debate.
The Functional Copy Number Variation-67048 in WWOX Contributes to Increased Risk of COPD in Southern and Eastern Chinese

Abstract Recent studies have recognized the genetic variants in the WW domain-containing oxidoreductase (WWOX) gene as genetic determinants of lung function, reflecting that the WWOX gene may be a susceptible factor of chronic obstructive pulmonary disease (COPD), which characters as poor lung function. We have previously showed that the copy number variation-67048 (CNV-67048) of WWOX was associated with lung cancer risk. Here, we hypothesized that the CNV-67048 affects COPD susceptibility. Based on a two-stage case-control study with a total of 1791 COPD patients and 1940 controls of southern and eastern Chinese, we found that the loss genotypes (0-copy and 1-copy) of CNV-67048 harbored a significantly increased risk of COPD, with an odds ratio (OR) as 1.29 (1.11–1.49) when compared with the common 2-copy genotype. The pre-forced expiratory volume in one second (pre-FEV1) to pre-forced vital capacity (pre-FVC) of carriers with loss genotypes (0.729 ± 0.130) was significantly lower than carriers with 2-copy genotype (0.747 ± 0.124; p = 7.93 × 10−5). However, no significant difference was observed on pre-FEV1, pre-FVC and the annual decline of pre-FEV1 between the loss genotypes and 2-copy genotype carriers. Our data suggest that the loss genotypes of CNV-67048 in WWOX predispose their carriers to COPD, which might be a genetic biomarker to predict risk of COPD in Chinese.