Miracle-dz/UniFAR-FTUs huggingface dataset:
Integration of STEM Education in Malaysia and Why to STEAM

STEM education and political priorities in the US and is rated as one way to ensure global competitiveness. Integrated approach to STEM school level gaining popularity in developed countries like the United States, South Korea, China and Australia. However, much of the debate and suggested that the study of art combined with appropriate discipline of science, technology, engineering and mathematics change STEM to STEAM. STEAM paradigm also emphasizes the importance of STEM education, but also stressed that the art has the ability to open up new ways of seeing, thinking and learning. Whereas current developments in Malaysia has started to show a deep interest and efforts on behalf of the Malaysian government to implement the STEM approach. This article discusses the development of STEM to STEAM education in the United States and the efforts made in Malaysia have begun to use this approach. This study is a qualitative study using literature review. This article proposes combining elements of art into the disciplines in STEM to STEAM in order to strengthen the STEM education, also suggest that the main thing to keep in mind to implement STEM education is to increase the interest of students and teachers' awareness of STEM education. This step involves a new approach to learning and strengthen the curriculum, teacher training and discussions with all interested parties (stakeholders) in order to make STEM education comprehensive and inclusive.
Soluble CD40 Ligand and Oxidative Response Are Reciprocally Stimulated during Shiga Toxin-Associated Hemolytic Uremic Syndrome

Shiga toxin (Stx), produced by Escherichia coli, is the main pathogenic factor of diarrhea-associated hemolytic uremic syndrome (HUS), which is characterized by the obstruction of renal microvasculature by platelet-fibrin thrombi. It is well known that the oxidative imbalance generated by Stx induces platelet activation, contributing to thrombus formation. Moreover, activated platelets release soluble CD40 ligand (sCD40L), which in turn contributes to oxidative imbalance, triggering the release of reactive oxidative species (ROS) on various cellular types. The aim of this work was to determine if the interaction between the oxidative response and platelet-derived sCD40L, as consequence of Stx-induced endothelium damage, participates in the pathogenic mechanism during HUS. Activated human glomerular endothelial cells (HGEC) by Stx2 induced platelets to adhere to them. Although platelet adhesion did not contribute to endothelial damage, high levels of sCD40L were released to the medium. The release of sCD40L by activated platelets was inhibited by antioxidant treatment. Furthermore, we found increased levels of sCD40L in plasma from HUS patients, which were also able to trigger the respiratory burst in monocytes in a sCD40L-dependent manner. Thus, we concluded that platelet-derived sCD40L and the oxidative response are reciprocally stimulated during Stx2-associated HUS. This process may contribute to the evolution of glomerular occlusion and the microangiopathic lesions.
Integrated Collaborative E-Learning for the Global Management Education in the 21st Century.

Rapidly growing information and communications technology and more interconnected global world offer benefits and challenges to global business organizations. While exploring benefits from global workforce and global production, they must successfully adapt to their local market conditions and manage their multicultural resources. How can we teach these rising complex global management challenges effectively in the 21st century global management classrooms? We need to pursue a new learning paradigm to foster active learners with innovative and critical global management thinking. Global management curricula should be designed to constantly draw forth active learning feedback to facilitate innovative learner-centered interactive classrooms. We closely examined the interactive learning models at the previous AACE Conferences (Son & Goldstone, 2012; Son & Simonian, 2014; Son, 2016). At the current Conference, we will discuss how integrated collaborative e-learning should be designed to improve these models using the example of a global online MBA course at Anaheim University. Using innovation and entrepreneurship as the subject matter, we closely examine the three pillars for global management education: leadership education, responsible education, and experiential education.
Experiences with the Co-design and Evaluation of Locative Media Experiences with the National Trust

In this paper we present our recent research work with the English Lake District National Trust. This work has involved the co-design of a Locative Media Experience for a rural valley in the Lake District. The co-design activity has sought to create an engaging visitor experience and one that fits with the key aims/values of the National Trust. The Locative Media Experience has received both domain expert evaluation and evaluation through public field trial over the Easter vacation period
Prevalence of Extradyadic Sex in Male Couples of Mixed HIV Status and Its Relationship to Psychological Distress and Relationship Quality

Abstract This study assessed the prevalence of extradyadic sex and the relationship between such activity and psychological distress and relationship quality in male couples of mixed HIV serostatus. Sixty-three couples were interviewed and had sufficient data for inclusion in all analyses. With regard to sexual activity during the year prior to being interviewed, 19 (30%) couples were monogamous, 18 (29%) described themselves as “open,” 13 (21%) kept extradyadic sex a secret from their partners, and in 13 couples there was only partial knowledge of extradyadic sex. Though not statistically significant, monogamous and open couples consistently scored lower numerically on measures of psychological distress and higher on measures of relationship quality, compared to “partial knowledge” and “secretive” couples. When pooled, monogamous and open couples scored significantly higher on measures of dyadic consensus, affectional expression, dyadic satisfaction, and sexual satisfaction compared to the combined subgroup of partial knowledge and secretive couples.
An Assessment of Correlation between Dermatoglyphic Patterns and Sagittal Skeletal Discrepancies.

INTRODUCTION Investigators over years have been fascinated by dermatoglyphic patterns which has led to the development of dermatoglyphics as a science with numerous applications in various fields other than being the best and most widely used method for personal identification. AIM To assess the correlation between dermatoglyphic patterns and sagittal skeletal discrepancies. MATERIALS AND METHODS A total of 180 patients, aged 18-40 years, were selected from those who attended the outpatient clinic of the Deparment of Orthodontics and Dentofacial Orthopedics, Mar Baselios Dental College, Kothamangalam, Kerala, India. The fingerprints of both hands were taken by ink and stamp method after proper hand washing. The patterns of arches, loops and whorls in fingerprints were assessed. The total ridge count was also evaluated. Data was also sent to the fingerprint experts for expert evaluation. The sagittal jaw relation was determined from the patient's lateral cephalogram. The collected data was then statistically analyzed using Chi-square tests, ANOVA and Post-hoc tests and a Multinomial regression prediction was also done. RESULTS A significant association was observed between the dermatoglyphic pattern exhibited by eight fingers and the sagittal skeletal discrepancies (p<0.05). An increased distribution of whorl pattern was observed in the skeletal Class II with maxillary excess group and skeletal Class II with mandibular deficiency group while an increased distribution of loop pattern was seen in the skeletal Class III with mandibular excess group and skeletal Class III with maxillary deficiency group. Higher mean of total ridge count was also seen in the groups of skeletal Class II with maxillary excess and skeletal Class II with mandibular deficiency. Multinomial regression predicting skeletal pattern with respect to the fingerprint pattern showed that the left thumb impression fits the best model for predicting the skeletal pattern. CONCLUSION There was a significant association between dermatoglyphic patterns and sagittal skeletal discrepancies. Dermatoglyphics could serve as a cost effective screening tool of these craniofacial problems.
Truncation Error Estimates in Process Life Cycle Assessment Using Input‐Output Analysis

Process life cycle assessment (PLCA) is widely used to quantify environmental flows associated with the manufacturing of products and other processes. As PLCA always depends on defining a system boundary, its application involves truncation errors. Different methods of estimating truncation errors are proposed in the literature; most of these are based on artificially constructed system complete counterfactuals. In this article, we review the literature on truncation errors and their estimates and systematically explore factors that influence truncation error estimates. We classify estimation approaches, together with underlying factors influencing estimation results according to where in the estimation procedure they occur. By contrasting different PLCA truncation/error modeling frameworks using the same underlying input‐output (I‐O) data set and varying cut‐off criteria, we show that modeling choices can significantly influence estimates for PLCA truncation errors. In addition, we find that differences in I‐O and process inventory databases, such as missing service sector activities, can significantly affect estimates of PLCA truncation errors. Our results expose the challenges related to explicit statements on the magnitude of PLCA truncation errors. They also indicate that increasing the strictness of cut‐off criteria in PLCA has only limited influence on the resulting truncation errors. We conclude that applying an additional I‐O life cycle assessment or a path exchange hybrid life cycle assessment to identify where significant contributions are located in upstream layers could significantly reduce PLCA truncation errors.
Use of a wild-type gene fusion to determine the influence of environmental conditions on expression of the S fimbrial adhesin in an Escherichia coli pathogen

S fimbrial adhesins (Sfa) enable pathogenic Escherichia coli strains to bind to sialic acid-containing eucaryotic receptor molecules. In order to determine the influence of culture conditions on the expression of the sfa determinant in a wild-type strain, we fused the gene lacZ, coding for the enzyme beta-galactosidase, to the sfaA gene, responsible for the major protein subunit of S fimbriae. By using a plasmid which carries an R6K origin, the sfaA-lac hybrid construct was site-specifically integrated into the chromosome of the uropathogenic E. coli strain 536WT. The expression of lacZ, which was under the control of the sfa wild-type promoters, was now equivalent to the sfa expression of strain 536WT. With the help of this particular wild-type construct, it was demonstrated that the sfa determinant is better expressed on solid media than in liquid broth. The growth rate had a strong influence on Sfa expression under aerobic but not under anaerobic conditions. Production of Sfa was further regulated by catabolite repression, osmolarity, and temperature.
Description of the finger mechanical load of climbers of different levels during different hand grips in sport climbing

Abstract Currently, direct empirical evidence exists about the amount of mechanical load that climbers apply to each finger during several hand grips specific to sport climbing, but not yet in a specific hanging position. The objectives of this study are a) to draw and build a solid and rigid support that simulates the real action of a hand grip in a hanging position in sport climbing, to enable the measurement of the mechanical load endured by the fingers in a hanging position and in addition, b) to describe the distribution of mechanical load among fingers as a function of the level of climbing during different hand grips in a hanging position. Thirty young male participants took part in the initial phase of reliability of the measurements, while another 64 male climbers participated in the subsequent study phase to check the relations between independent and dependent variables. The level of on sight climbing and the total practice experience were used to define the groups. The research task consisted of performing hanging positions on the created support in order to measure the mechanical load endured by the fingers in the three most characteristic hand grips in climbing (crimp, half crimp and slope). It has been concluded that the performance level of the climbers had no influence on the production of a pattern of differentiated finger mechanical load during the research task.
The Impact of Remittance on Trade Balance: The Case of Malaysia

The paper aims to examines impact of remittance on Malaysia’s trade balance in last over two decades. Using Ordinary Least Squares (OLS) regression model based on the annual data for twenty five years period from 1990 to 2015 to test the impact of remittance on the trade balance. The results showed the remittance influence on the trade balance positively. Our findings indicate that Malaysia did not face a symptom of Dutch disease impacted by the remittance. This is not surprised due to a small remittance to Malaysia, however, the interesting is that the remittance’s fluctuation is semilar to trade balance’s one.
Detection of Receptor Heteromerization Using In Situ Proximity Ligation Assay

Although G protein‐coupled receptor (GPCR) heteromerization has been extensively demonstrated in vitro using heterologous cells that overexpress epitope‐tagged receptors, their presence in endogenous systems is less well established. This is because a criterion to identify receptor heteromerization is the demonstration that the two interacting receptors are present not only in the same cell but also in the same subcellular compartment in close enough proximity to allow for direct receptor‐receptor interaction. This has been difficult to study in native tissues due to a lack of sensitive and selective tools not only capable of detecting low‐abundance proteins but also of demonstrating that they are in sufficiently close proximity to interact. The latter can be achieved using a proximity ligation assay (PLA). Detailed in this unit are protocols for demonstrating the presence of GPCR heteromers in endogenous cells as well as animal and human tissues, the controls required for these assays, and troubleshooting tips. © 2016 by John Wiley & Sons, Inc.
The European Bioinformatics Institute (EBI) databases

This paper describes the databases and services of the European Bioinformatics Institute (EBI). In collaboration with DDBJ and GenBank/NCBI, the EBI maintains and distributes the EMBL Nucleotide Sequence Database, Europe's primary nucleotide sequence data resource. The EBI also maintains and distributes the SWISS-PROT Protein Sequence Database, in collaboration with Amos Bairoch of the University of Geneva. Over thirty additional specialist molecular biology databases, as well as software and documentation of interest to molecular biologists, are also available. The EBI network services include database searching, entry retrieval, and sequence similarity searching facilities.
Safety and Efficacy of Fluvastatin in Hyperlipidemic Patients With Chronic Renal Disease

Background. There are few reports on the safety and efficacy of long‐term treatment with statins in patients with chronic renal disease and hyperlipidemia. We evaluated these subjects treated with fluvastatin.Methods. After a 4‐week run‐in period, a total of 80 patients with diabetic nephropathy or chronic glomerulonephritis were randomly allocated to receive dietary therapy and fluvastatin 20 mg/day (n = 39), or dietary therapy alone (n = 41) for a period of 48 weeks. Lipid parameters, rhabdomyolysis‐related indicators, 24‐hour urinary albumin excretion and creatinine clearance were measured. The pharmacokinetics of fluvastatin was examined in 8 patients. Results. Creatinine clearance and 24‐hour urinary albumin excretion did not differ between the two groups. The peak serum fluvastatin concentration (Cmax) was 141 ± 67 µg/L and the mean AUC0–6 h was 341 ± 149 µg · h/L. Fluvastatin treatment significantly lowered serum total cholesterol, low‐density lipoprotein (LDL) cholesterol and apo‐lipoprotein B concentrations by 16%, 25%, and 22%, respectively, compared with patients receiving dietary therapy alone. There were no significant differences in serum triglyceride and high‐density lipoprotein (HDL) cholesterol concentrations between the two treatment groups. Serum creatine kinase and aldolase concentrations did not change throughout treatment in both groups. Conclusions. Fluvastatin treatment significantly improved lipid parameters in patients with chronic renal disease. Fluvastatin was well tolerated, with no adverse effects on renal function and no muscular toxicity. However, the drug showed no direct renoprotective effects.
Rethinking wife abuse: violence, resistance, and public policy in Canada

How does public policy influence wife abuse? This dissertation attempts to answer this question by using the lens of women’s resistance to analyse the Canadian anti-wife abuse policy framework. It is argued that the goal of the current anti-violence policy framework is protection, instrumental to which is departure, imposing exit on women. Resistance is narrowly defined only as departure from the household, falsely dichotomizing women who leave as resistors and women who stay as victims. In doing so, public policy benefits only a few women, those who want to and can leave. Other women, those who do not want the relationship to end and those who cannot sustain themselves without their partner, are defined away from the policy framework. In addition, the policy framework is premised on “choice” but fails to account for the context in which choice takes place. This construction of resistance places a number of barriers on women attempting to resist abuse, which are shown analytically, using a feminist bargaining approach coupled with outside options theory, and empirically, using data from the General Social Survey on Victimization 1999 to test binary logit and tobit models, as well as independent samples tests. It is demonstrated that women’s resistance is not a question of agency, but rather of public policy. Thus, by shifting the goal of policy away from protection/exit towards the broader objective of prevention/enabling women to live without violence, a much broader scope of resistance strategies is accommodated.
Effects of Topical Cova™, Tisseel® and Adcon® Gel Application on the Development of Spinal Peridural Fibrosis: An Experimental Study in Rats.

AIM Leptomeningeal adhesions and fibrosis in the spinal peridural space are the most common causes of post-laminectomy syndrome. Fibrin sealant agents and membrane barriers are commonly used for hemostasis and sealing purposes in spinal surgery. Peridural fibrosis may be a risk of the usage of these topical agents. In this study, we aimed to compare the effects of Cova ™, Tisseel® and Adcon ® Gel on the development of spinal peridural fibrosis in the experimental rat model. MATERIAL AND METHODS Thirty-two Sprague Dawley female rats were randomly divided into 4 groups. Groups were constituted as group 1; Cova™ group (laminectomy+Cova™), group 2; Tisseel® group (laminectomy+Tisseel®), group 3; Adcon®Gel group (laminectomy + Adcon®Gel), group 4; control group (laminectomy only). Six weeks after laminectomy, spinal columns were removed en bloc between L1 and L4 vertebrae. Peridural fibrosis was evaluated histologically and the results were compared statistically. RESULTS Statistically significant reduction of peridural fibrosis was achieved in groups 1, 2, and 3 when compared with the control group (p < 0.05). Our data revealed a statistically significant difference between group 1 and group 3 (p < 0.05). When we compared with group 2 and 3, the fibrosis grades were not different between these two groups (p > 0.05). CONCLUSION Fibrin sealant agent Tisseel® and membrane barrier Cova™ do not enhance peridural fibrosis following laminectomy. Cova™ and Tisseel® may be appropriate for hemostasis and leakage prevention during the spinal surgery and it is safe to leave these materials on the operation surface.
Disrupting Daesh: Measuring Takedown of Online Terrorist Material and Its Impacts

Abstract This article contributes to public and policy debates on the value of social media disruption activity with respect to terrorist material. In particular, it explores aggressive account and content takedown, with the aim of accurately measuring this activity and its impacts. The major emphasis of the analysis is the so-called Islamic State (IS) and disruption of their online activity, but a catchall “Other Jihadi” category is also utilized for comparison purposes. Our findings challenge the notion that Twitter remains a conducive space for pro-IS accounts and communities to flourish. However, not all jihadists on Twitter are subject to the same high levels of disruption as IS, and we show that there is differential disruption taking place. IS’s and other jihadists’ online activity was never solely restricted to Twitter; it is just one node in a wider jihadist social media ecology. This is described and some preliminary analysis of disruption trends in this area supplied too.
Two‐dimensional electrophoresis database of Listeria monocytogenes EGDe proteome and proteomic analysis of mid‐log and stationary growth phase cells

Listeria monocytogenes is the causative agent of listeriosis, one of the mo#st significant foodborne diseases in industrialized countries. The complete genome of the L. monocytogenes EGDe strain, belonging to the serogroup 1/2a, has been sequenced and is comprised of 2853 open reading frames. The objective of the current study was to construct a two‐dimensional (2‐D) database of the proteome of this strain. The soluble protein fractions of the microorganism were recovered either in the mid‐log or in the stationary phase of growth at 37°C. These fractions were analyzed by 2‐D electrophoresis (2‐DE), using immobilized pH gradient strips of various pH values (3–10, 3–6, and 5–8) for the first‐dimensional separations and 12.5% acrylamide gels for sodium dodecyl sulfate‐polyacrylamide gel electrophoresis (SDS‐PAGE). 201 protein spots corresponding to 126 different proteins were identified by matrix assisted laser desorption/ionization‐time of flight‐mass spectrometry (MALDI‐TOF‐MS). The 2‐DE maps presented here provide a first basis for further investigations of protein expression in L. monocytogenes. In this way, the comparison of proteome between cells in the exponential or stationary phase of growth at 37°C allowed us to characterize 161 variations in protein spot intensity, of which 38 were identified. Among the differentially expressed proteins were ribosomal proteins (RpsF, RplJ, and RpmE), proteins involved in cellular metabolism (GlpD, PdhD, Pgm, Lmo1372, Lmo2696, and Lmo2743) or in stress adaptation (GroES and ferritin), a fructose‐specific phosphotransferase enzyme IIB (Lmo0399) and different post‐translational modified forms of listeriolysin (LLO).