Miracle-dz/UniFAR-FTUs huggingface dataset:
Crescimento e mortalidade em um rebanho de conservação de caprinos Marota no Brasil.

O caprino Marota consiste em um importante recurso genetico adaptado ao Semiarido brasileiro e encontra-se em risco de extincao. A Embrapa Meio-Norte mantem um nucleo de conservacao destes caprinos no municipio de Castelo do Piaui, regiao de transicao caatinga-cerrado. O manejo deste rebanho e semi-extensivo para sobrepujar as caracteristicas de rusticidade do ecotipo Marota. Esta pesquisa foi realizada com o objetivo de monitorar o desempenho fenotipico do nucleo com relacao ao peso ao nascimento, prolificidade e mortalidade nos anos de 2004 a 2008, e relaciona-los a outros dados observados no Semiarido e obtidos na literatura especializada. As medias obtidas corrigidas foram 1,89±0,09 e 22,8±5,9 kg, respectivamente para peso ao nascer e peso ao parto. Os resultados obtidos demonstram peso ao nascer abaixo das racas exoticas no Semiarido e de ecotipos brasileiros em menor risco de extincao (p.ex. Moxoto). As taxas de mortalidade e a prolificidade obtidas sao vantajosas em relacao as apresentadas por racas exoticas presentes no Semiarido, mas nao superiores aos demais tipos naturalizados. Estudos economicos devem estabelecer se a relacao entre tais caracteristicas implicam em eficiencia para o sistema produtivo.
Long-term outcome of chronic hepatitis B in Caucasian patients: mortality after 25 years

Objective: To assess risk factors for liver-related death, we re-evaluated, after a median follow-up of 25 years, a cohort of 70 Caucasian patients with hepatitis B e antigen (HBeAg) positive chronic hepatitis (CH) at presentation. Methods: Follow-up studies included clinical and ultrasound examinations, biochemical and virological tests, and cause of death. Results: Sixty-one (87%) patients underwent spontaneous HBeAg seroconversion. During a median period of 22.8 years after HBeAg seroclearance, 40 (66%) patients became inactive carriers, whereas the remaining 21 (34%) showed alanine aminotransferase elevation: one (1%) had HBeAg reversion, nine (15%) detectable serum HBV DNA but were negative for HBeAg, eight (13%) concurrent virus(es) infection and three (5%) concurrent non-alcoholic fatty liver disease. Liver-related death occurred in 11 (15.7%) patients, caused by hepatocellular carcinoma in five and liver failure in six. The 25-year survival probability was 40% in patients persistently HBeAg positive, 50% in patients with HBeAg negative CH or HBeAg reversion and 95% in inactive carriers. Older age, male sex, cirrhosis at entry and absence of sustained remission predicted liver-related death independently. The adjusted hazard ratios (95% CI) for liver related death were 33 (3.01–363) for persistently HBeAg positive patients and 38.73 (4.65–322) for those with HBeAg negative CH or HBeAg reversion relative to inactive carriers. Conclusion: Most patients with HBeAg seroconversion became inactive carriers with very good prognosis. The risk of liver-related mortality in Caucasian adults with CH is strongly related with sustained disease activity and ongoing high level of HBV replication independently of HBeAg status.
Austrian height and body proportion references for children aged 4 to under 19 years

Abstract Background: Previous studies have demonstrated differences between national and the WHO reference curves in children older than 5 years. Moreover, reference curves for body proportions (sitting height, subischial leg length and their ratio) based on state-of-the-art statistics are not available. Aim: To develop reference curves for height and body proportions for use in Austria and compare the curves with WHO reference curves. To estimate and statistically investigate extreme percentiles. Subjects and methods: A sample of ∼14 500 children between 4–19 years of age was drawn via schooling institutions, stratified by provinces according to age- and sex-specific population proportions. GAMLSS models were used for a flexible estimation of percentile curves. Results and conclusions: After the age of 5 years national reference curves are more suitable than the WHO reference curves for clinical use in Austria. These height curves are very similar to the German reference curves published recently. Therefore, these reference curves for criteria of body proportions are recommended for use in other populations. Further validation studies are needed to establish whether the recently recommended −2.5 and −3.0 SD for height are a sensitive and specific cut-off in the diagnostic work-up for children with a suspected growth disorder using this new Austrian height chart.
Grammatica di riferimento dell'italiano contemporaneo

Categoria: Lingue , Sapere Tag: imparare, lingua, italiano, conoscere, consultare, grammatica, dizionario ISBN: 9788848040310 Data di uscita: 2006 Numero di Pagine: 528 Lingua: italiano Prezzo: € 19 Descrizione prodotto La Grammatica di riferimento dell’italiano contemporaneo si presenta come una sintesi dei risultati piu avanzati ottenuti dalla ricerca linguistica italiana nel campo della produzione di grammatiche scientifiche, scolastiche e per stranieri. Descrive le strutture grammaticali e sintattiche dell'italiano attuale in modo completo e scientificamente rigoroso, e al tempo stesso chiaro e accessibile a tutti. Le nozioni prettamente teoriche, infatti, sono ridotte al minimo indispensabile e i termini tecnici sono quasi del tutto abbandonati. Nell'opera si da invece largo spazio ai tanti elementi di novita e di cambiamento che si registrano nell'italiano contemporaneo, sui quali quotidianamente si appuntano i dubbi di chi parla e scrive.
Evaluation of antipyretic activity of leaf extracts of Mallotus peltatus (Geist) Muell. arg. var acuminatus: a folk medicine.

A study was carried out to evaluate the anti-pyretic potential of the methanol extract of Mallotus peltatus (Geist) Muell. Arg. var acuminatus leaf, a folk medicine of Onge tribes of Bay Islands, on normal body temperature and yeast-induced pyrexia in Wister albino rats. The leaf extract at oral doses of 100, 200 and 300 mg kg(-1), p.o. , showed significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose-dependent manner and the anti-pyretic effect was comparable to that of standard anti-pyretic agent paracetamol (150 mg kg(-1), p.o. ). The effect also extended up to 5 hours after the drug administration.
Bone mineral density and biochemical markers of bone turnover in patients with predialysis chronic renal failure.

BACKGROUND Metabolic bone disease might commence early in the course of renal failure. This study therefore examined the frequency and severity of the skeletal changes in predialysis chronic renal failure by measurements of bone mineral density (BMD), biochemical markers of bone turnover (osteocalcin, bone-specific alkaline phosphatase, carboxy terminal propeptide of type I collagen, and carboxy-terminal telopeptide of type I collagen), parathyroid hormone (PTH), ionized calcium (Ca++), phosphate (P), and vitamin D metabolites. METHODS The study was performed in 113 patients (male/female: 82/31) with chronic renal diseases [mean glomerular filtration rate (GFR) of 37 ml/min] and in 89 matched, normal control subjects. RESULTS The patients had significantly (P<0.05) reduced BMD in the spine (-6.3%), the femur (-12.1%), the forearm (-5.7%), and the total body (-4.2%) as compared with the control subjects. Dividing the patients into quartiles according to GFR revealed that BMD decreased with the gradual decline in renal function at all the measured skeletal sites, but was most pronounced in the femur: 0.63+/-0.03, 0.74+/-0.02, 0.77+/-0.02, and 0.82+/-0.03 g/cm2 in each quartile from lowest to highest GFR compared with 0.82+/-0.02 g/cm2 in the control group (P<0.0001). All of the measured bone markers showed increasing plasma levels with the more advanced stages of renal failure. Serum PTH and serum P levels increased, whereas serum Ca++ and 1,25-dihydroxyvitamin D decreased. BMD Z-scores of the femur and of the forearm correlated to the biochemical markers and to PTH (P<0.05 to P<0.0001). The biochemical markers all showed strong correlations to PTH, also when corrected for the effect of the decline in GFR (r = 0.40 to 0.92, P<0.01 to P< 0.0001). CONCLUSION Skeletal changes are initiated at an early stage of chronic renal failure, as estimated from reduced BMD and elevated levels of PTH and from the biochemical markers of both bone formation and bone resorption.
Assessing Long-Term Outcomes of Open and Endoscopic Sagittal Synostosis Reconstruction Using Three-Dimensional Photography

AbstractSagittal synostosis has been successfully managed with numerous surgical techniques. Nevertheless, few data on long-term outcomes exist to justify use of one surgical technique over another. In this study, we compared children with surgically corrected sagittal synostosis to their age-matched control subjects to assess the longevity of their corrections. Furthermore, the outcomes of open repairs were compared with endoscopic repairs.Following institutional review board approval, three-dimensional photographs of patients who underwent surgical reconstruction for nonsyndromic sagittal synostosis were analyzed to determine biparietal and anterior-posterior diameter, circumference, cephalic index, cranial vault volume, cranial height, and forehead inclination. Thirteen patients who had undergone open repair, including 6 total cranial vault and 7 modified-pi reconstructions, and 6 patients who had undergone endoscopic strip craniectomy with barrel-stave osteotomies and postoperative helmeting were compared with nonsynostotic age-matched control subjects. Mean follow-up was 97.5 months after open and 48.9 months after endoscopic repair. Student t tests were used for analysis. In the second arm of this study, 33 patients who had undergone endoscopic repair were compared with the 13 patients who had undergone open repair; mean follow-up was 24.8 months after endoscopic repair. Linear regression models were used to adjust for age and sex.After comparing three-dimensional photographs of children who were more than 3 years postoperative from surgical correction for sagittal synostosis with their age-matched control subjects, no statistically significant differences were found in any of the measured parameters. In addition, no differences were detected between open reconstruction versus endoscopic repair, suggesting equivalence in final results for both procedures.
Autocrine embryotropins revisited: how do embryos communicate with each other in vitro when cultured in groups?

In the absence of the maternal genital tract, preimplantation embryos can develop in vitro in culture medium where all communication with the oviduct or uterus is absent. In several mammalian species, it has been observed that embryos cultured in groups thrive better than those cultured singly. Here we argue that group‐cultured embryos are able to promote their own development in vitro by the production of autocrine embryotropins that putatively serve as a communication tool. The concept of effective communication implies an origin, a signalling agent, and finally a recipient that is able to decode the message. We illustrate this concept by demonstrating that preimplantation embryos are able to secrete autocrine factors in several ways, including active secretion, passive outflow, or as messengers bound to a molecular vehicle or transported within extracellular vesicles. Likewise, we broaden the traditional view that inter‐embryo communication is dictated mainly by growth factors, by discussing a wide range of other biochemical messengers including proteins, lipids, neurotransmitters, saccharides, and microRNAs, all of which can be exchanged among embryos cultured in a group. Finally, we describe how different classes of messenger molecules are decoded by the embryo and influence embryo development by triggering different pathways. When autocrine embryotropins such as insulin‐like growth factor‐I (IGF‐I) or platelet activating factor (PAF) bind to their appropriate receptor, the phosphatidylinositol‐4,5‐bisphosphate 3‐kinase (PI3K) pathway will be activated which is important for embryo survival. On the other hand, the mitogen‐activated protein kinase (MAPK) pathway is activated when compounds such as hyaluronic acid and serotonin bind to their respective receptors, thereby acting as growth factors. By activating the peroxisome‐proliferator‐activated receptor family (PPAR) pathway, lipophilic autocrine factors such as prostaglandins or fatty acids have both survival and anti‐apoptotic functions. In conclusion, considering different types of messenger molecules simultaneously will be crucial to understanding more comprehensively how embryos communicate with each other in group‐culture systems. This approach will assist in the development of novel media for single‐embryo culture.
A simple algorithm to predict the development of radiological erosions in patients with early rheumatoid arthritis: prospective cohort study

Abstract Objective: To produce a practical algorithm to predict which patients with early rheumatoid arthritis will develop radiological erosions. Design: Primary care based prospective cohort study. Setting: All general practices in the Norwich Health Authority, Norfolk Subjects: 175 patients notified to the Norfolk Arthritis Register were visited by a metrologist soon after they had presented to their general practitioners with inflammatory polyarthritis, and again after a further 12 months. All the patients satisfied the American Rheumatism Association's 1987 criteria for rheumatoid arthritis and were seen by a metrologist within six months of the onset of symptoms. The study population was randomly split into a prediction sample (n = 105) for generating the algorithm and a validation sample (n = 70) for testing it. Main outcome measures: Predictor variables measured at baseline included rheumatoid factor status, swelling of specific joint areas, duration of morning stiffness, nodules, disability score, age, sex, and disease duration when the patient first presented. The outcome variable was the presence of radiological erosions in the hands or feet, or both, after 12 months. Results: A simple algorithm based on a combination of three variables—a positive rheumatoid factor test, swelling of at least two large joints, and a disease duration of more than three months—was best able to predict erosions. When the accuracy of this algorithm was tested with the validation sample, the erosion status of 79% of patients was predicted correctly. Conclusions: A simple algorithm based on three easily measured items of information can predict which patients are at high risk and which are at low risk of developing radiological erosions.
Differential aggregation of the Trembler and Trembler J mutants of peripheral myelin protein 22

Mutations in the gene encoding the peripheral myelin protein 22 (PMP22), a tetraspan protein in compact peripheral myelin, are one of the causes of inherited demyelinating peripheral neuropathy. Most PMP22 mutations alter the trafficking of the PMP22 protein in Schwann cells, and this different trafficking has been proposed as the underlying mechanism of the disease. To explore this problem further, we compared the aggregation of wild-type Pmp22 with those of the two Pmp22 mutations found in Trembler (Tr) and Trembler J (TrJ) mice. All three Pmp22s can be crosslinked readily as homodimers in transfected cells. Wild-type Pmp22 also forms heterodimers with Tr and TrJ Pmp22, and these heterodimers traffic with their respective mutant Pmp22 homodimers. All three Pmp22s form complexes larger than dimers with Tr Pmp22 especially prone to aggregate into high molecular weight complexes. Despite the differences in aggregation of Tr and TrJ Pmp22, these two mutant Pmp22s sequester the same amount of wild-type Pmp22 in heterodimers and heterooligomers. Thus, the differences in the phenotypes of Tr and TrJ mice may depend more on the ability of the mutant protein to aggregate than on the dominant-negative effect of the mutant Pmp22 on wild-type Pmp22 trafficking.
ICP with Bounded Scale for Registration of M-D Point Sets

The iterative closest point (ICP) algorithm is an accurate and fast approach for registration between two point sets in a same scale, but it doesn't handle the case with different scales. This paper instead introduces a novel approach named the iterative closest point with bounded scale (ICPBS) algorithm which integrates a scale with boundaries into the traditional ICP algorithm. This proposed technique uses the singular value decomposition algorithm and the properties of parabola to compute the similar transformation at each iterative step, and yields more satisfying robust results than the traditional ICP method in registration between two m-D point sets with different scales. Experimental results demonstrate the presented method is robust and fast for practical use.
Anesthesia-related Cardiac Arrest in Children: Initial Findings of the Pediatric Perioperative Cardiac Arrest (POCA) Registry

Background The Pediatric Perioperative Cardiac Arrest (POCA) Registry was formed in 1994 in an attempt to determine the clinical factors and outcomes associated with cardiac arrest in anesthetized children. Methods Institutions that provide anesthesia for children are voluntarily enrolled in the POCA Registry. A representative from each institution provides annual institutional demographic information and submits anonymously a standardized data form for each cardiac arrest (defined as the need for chest compressions or as death) in anesthetized children 18 yr of age or younger. Causes and factors associated with cardiac arrest are analyzed. Results In the first 4 yr of the POCA Registry, 63 institutions enrolled and submitted 289 cases of cardiac arrest. Of these, 150 arrests were judged to be related to anesthesia. Cardiac arrest related to anesthesia had an incidence of 1.4 ± 0.45 (mean ± SD) per 10,000 instances of anesthesia and a mortality rate of 26%. Medication-related (37%) and cardiovascular (32%) causes of cardiac arrest were most common, together accounting for 69% of all arrests. Cardiovascular depression from halothane, alone or in combination with other drugs, was responsible for two thirds of all medication-related arrests. Thirty-three percent of the patients were American Society of Anesthesiologists physical status 1–2; in this group, 64% of arrests were medication-related, compared with 23% in American Society of Anesthesiologists physical status 3–5 patients (P < 0.01). Infants younger than 1 yr of age accounted for 55% of all anesthesia-related arrests. Multivariate analysis demonstrated two predictors of mortality: American Society of Anesthesiologists physical status 3–5 (odds ratio, 12.99; 95% confidence interval, 2.9–57.7), and emergency status (odds ratio, 3.88; 95% confidence interval, 1.6–9.6). Conclusions Anesthesia-related cardiac arrest occurred most often in patients younger than 1 yr of age and in patients with severe underlying disease. Patients in the latter group, as well as patients having emergency surgery, were most likely to have a fatal outcome. The identification of medication-related problems as the most frequent cause of anesthesia-related cardiac arrest has important implications for preventive strategies.
Two Siblings with Homozygous Pathogenic Splice‐Site Variant in Mitochondrial Asparaginyl–tRNA Synthetase (NARS2)

A homozygous missense mutation (c.822G>C) was found in the gene encoding the mitochondrial asparaginyl–tRNA synthetase (NARS2) in two siblings born to consanguineous parents. These siblings presented with different phenotypes: one had mild intellectual disability and epilepsy in childhood, whereas the other had severe myopathy. Biochemical analysis of the oxidative phosphorylation (OXPHOS) complexes in both siblings revealed a combined complex I and IV deficiency in skeletal muscle. In‐gel activity staining after blue native‐polyacrylamide gel electrophoresis confirmed the decreased activity of complex I and IV, and, in addition, showed the presence of complex V subcomplexes. Considering the consanguineous descent, homozygosity mapping and whole‐exome sequencing were combined revealing the presence of one single missense mutation in the shared homozygous region. The c.822G>C variant affects the 3′ splice site of exon 7, leading to skipping of the whole exon 7 and a part of exon 8 in the NARS2 mRNA. In EBV‐transformed lymphoblasts, a specific decrease in the amount of charged mt‐tRNAAsn was demonstrated as compared with controls. This confirmed the pathogenic nature of the variant. To conclude, the reported variant in NARS2 results in a combined OXPHOS complex deficiency involving complex I and IV, making NARS2 a new member of disease‐associated aaRS2.
Towards decoding of functional movements from the same limb using EEG

In recent years, there has been an increasing interest in using electroencephalographic (EEG) activity to close the loop between brain oscillations and movement to induce functional motor rehabilitation. Rehabilitation robots or exoskeletons have been controlled using EEG activity. However, all studies have used a 2-class or one-dimensional decoding scheme. In this study we investigated EEG decoding of 5 functional movements of the same limb towards an online scenario. Six healthy participants performed a three-dimensional center-out reaching task based on direction movements (four directions and rest) wearing a 32-channel EEG cap. A BCI design based on multiclass extensions of Spectrally Weighted Common Spatial Patterns (Spec-CSP) and a linear discriminant analysis (LDA) classifier was developed and tested offline. The decoding accuracy was 5-fold cross-validated. A decoding accuracy of 39.5% on average for all the six subjects was obtained (chance level being 20%). The results of the current study demonstrate multiple functional movements decoding (significantly higher than chance level) from the same limb using EEG data. This study represents first steps towards a same limb multi degree of freedom (DOF) online EEG based BCI for motor restoration.
Strong Coordination Over Multi-Hop Line Networks Using Channel Resolvability Codebooks

We analyze the problem of strong coordination over a multi-hop line network in which the node initiating the coordination is a terminal network node. We assume that each node has access to a certain amount of randomness that is local to the node, and that the nodes also have shared common randomness, which are used together with explicit hop-by-hop communication to achieve information-theoretic strong coordination. We derive the trade-offs among the required rates of communication on the network links, the rates of local randomness available at network nodes, and the rate of common randomness to realize strong coordination. We present an achievable coding scheme built using multiple layers of channel resolvability codes, and establish several settings in which this scheme offers the best possible trade-offs among network resources.
A Calibration-Free Low-Cost Process-Compensated Temperature Sensor in 130 nm CMOS

A calibration-free low-cost CMOS integrated smart temperature sensor is presented that requires significantly less die area than previously published designs through the use of novel circuit technique and the 130 nm CMOS process. Uncalibrated sensor operation is achieved through the extensive use of analog dynamic element matching and chopper stabilization circuitry. A novel process-compensation circuit is presented that uses the correlation between pinch-base resistance and substrate bipolar VBE temperature gradient. Accuracy mostly within the range of ±1°C was achieved using a die area of only 0.21 sq. mm. Prototype sensor performance was found to be limited by the low β characteristics of the substrate bipolar transistors implemented in the 130 nm CMOS process.