Miracle-dz/UniFAR-FTUs huggingface dataset:
The evaluation of the outcome in myelodysplastic patients by using non-cytogenetic prognostic scores

Abstract Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders; they are characterized by ineffective hematopoiesis and a predilection to the development of acute myeloid leukemia (AML). For a rapid evaluation of the outcome in myelodysplastic patients non-cytogenetic prognostic scores can be used. Aim: This study proposed to demonstrate that age and gender are important factors in the outcome of the patients diagnosed with myelodysplastic syndrome. Materials and methods: This study was conducted in the Department of Hematology of the Emergency University Hospital Bucharest during October 2008 and October 2012. Results: Male sex and age higher than 60 years are associated with high risk in the studied cases by using the Spanish prognostic score. According to Goasguen score: male sex and age, patients older than 60 years, present characteristics associated with an intermediate risk. Based on the Dusseldorf score, age over 60 years and female gender were associated with pronounced risk in the examined group. By examining the Bournemouth score in our group, we found that age > 60 years correlated with a higher frequency of risk, but no significant differences regarding the sex of patients were observed. Conclusions: We concluded that age > 60 years and male gender are important predisposing factors in the survival. Abbreviations MDS = myelodysplastic syndromes, AML = acute myeloid leukemia, LDH = lactate dehydrogenase, FAB = French-American-British, WHO = World Health Organization, IPSS = International Prognostic Scoring System, ALIP = abnormal localization of immature precursors, WPSS = WHO classification-based prognostic scoring system, FISH = fluorescence in situ hybridization, del = deletion.
Human Cdc34 and Rad6B Ubiquitin-Conjugating Enzymes Target Repressors of Cyclic AMP-Induced Transcription for Proteolysis

ABSTRACT Ubiquitin-mediated proteolysis controls diverse physiological processes in eukaryotes. However, few in vivo targets of the mammalian Cdc34 and Rad6 ubiquitin-conjugating enzymes are known. A yeast-based genetic assay to identify proteins that interact with human Cdc34 resulted in three cDNAs encoding bZIP DNA binding motifs. Two of these interactants are repressors of cyclic AMP (cAMP)-induced transcription: hICERIIγ, a product of the CREM gene, and hATF5, a novel ATF homolog. Transfection assays with mammalian cells demonstrate both hCdc34- and hRad6B-dependent ubiquitin-mediated proteolysis of hICERIIγ and hATF5. This degradation requires an active ubiquitin-conjugating enzyme and results in abrogation of ICERIIγ- and ATF5-mediated repression of cAMP-induced transcription. Consistent with these results, the endogenous ICER protein is elevated in cells which are null for murine Rad6B (mHR6B −/−) or transfected with dominant negative and antisense constructs of human CDC34. Based on the requirement for CREM/ICER and Rad6B proteins in spermatogenesis, we determined expression of Cdc34, Rad6B, CREM/ICER isoforms, and the Skp1–Cullin–F-box ubiquitin protein ligase subunits Cul-1 and Cul-2, which are associated with Cdc34 activity during murine testicular development. Cdc34, Rad6B, and the Cullin proteins are expressed in a developmentally regulated manner, with distinctly different patterns for Cdc34 and the Cullin proteins in germ cells. The Cdc34 and Rad6B proteins are significantly elevated in meiotic and postmeiotic haploid germ cells when chromatin modifications occur. Thus, the stability of specific mammalian transcription factors is the result of complex targeting by multiple ubiquitin-conjugating enzymes and may have an impact on cAMP-inducible gene regulation during both meiotic and mitotic cell cycles.
A climatological study of sea breezes in Alicante.Sea breeze fronts over the iberian mediterranean area and the isle of Mallorca

Las brisas marinas son no de los fenomenos atmosfericos mas importantes en la costa. Esta circulacion local tiene una influencia decisiva en el tiempo y clima de la costa e interior y, por tanto, afecta directamente la vida humana. Las brisas marinas han sido estudiadas desde Aristoteles, quien fue el primer cientifico que escribio sobre el viento en su obra Meterorologica. Desde entonces, ha habido un incremento en el interes cientifico sobre las brisas marinas en todo el mundo. Esta tesis constituye un exhaustivo estudio climatologico de las brisas marinas. Nuestro objetivo es obtener un mejor conocimiento de ese fenomeno y de su capacidad para desarrollar frentes de brisa marina. Asi, se estructura en dos partes. La primera parte esta dedicada al desarrollo de metodologias para la seleccion de episodios de brisa marina. El estudio aplica una metodologia automatica y manual para crear dos bases de datos de calidad durante el periodo de estudio 2000-2005:(a) una primera con un numero elevado de eventos de brisa marina identificados mediante la seleccion manual, y (b) una segunda con los principales parametros de las brisas marinas detectadas por el procedimiento automatico. Ademas , se ha definido un primer filtro automatico basado en la diferencia regional de presion con el fin de mejorar la precision con el fin de mejorar la precision y tiempo de proceso de las tecnicas de seleccion. Estas dos bases de datos han sido utilizadas satisfactoriamente para investigar el grado de ocurrencia y persistencia, las principales caracteristicas y el efecto de los flujos de escala sinoptica sobre la evolucion de las brisas marinas por un area de estudio local: la provincia de Alicante, con especial atencion a la bahia de Alicante (sureste de la Peninsula Iberica, Espana). La segunda parte trata del estudio de los frentes de brisa marina, y su objetivo es identificar las zonas de convergencia de las brisas marinas asociadas con conveccion y actividad nubosa, utilizando un ano (2004) de datos de teledeteccion para un area de estudio regional: el area mediterranea de la Peninsula Iberica y la isla de Mallorca. En este apartado tambien se han investigado las nubes de brisa marina en la capa fronteriza interna termica y en la zona de convergencia de las brisas marinas sobre el llano costero y las montanas prebelicas de Alicante. El importante impacto humano(economico, social y sanitario) y climatico-ambiental de las brisas marinas avala el interes de la tesis y justifica el posible uso de sus resultados como un punto de partida para el diseno de politicas especificas en diferentes campos: turismo , servicios, deporte, desarrollo urbanistico y medio ambiente(problemas de calidad del aire, etc.).
Delay lines based on left-handed transmission line structure

Delay lines based on left-handed transmission line (LH-TL) structure are designed. The simulation results demonstrate that the LH-TL time delay lines possess higher delay efficiency than traditional right-handed transmission line (RH-TL) ones. The present delay line is more suitable for practical applications since it can be fabricated easily on printed circuit board (PCB) and compactable with other elements without any conversion devices. Besides, the present delay line has advantages of broad bandwidth and low insertion loss. Controllable phase constant beta of LH-TL structure is utilized to give diversity of delay lines and more time delay can be obtained provided a bigger beta is designed. Furthermore, LH-TL delay lines also provide an alternative choice to realize high temperature superconducting (HTS) delay lines
Comment on Qian et al. 2008: La Niña and El Niño composites of atmospheric CO2 change

It is well known that interannual extremes in the rate of change of atmospheric CO2 are strongly influenced by the occurrence of El Niño-Southern Oscillation (ENSO) events. Qian et al. presented ENSO composites of atmospheric CO2 changes. We show that their composites do not reflect the atmospheric changes that are most relevant to understanding the role of ENSO on atmospheric CO2 variability. We present here composites of atmospheric CO2 change that differ markedly from those of Qian et al., and reveal previously unreported asymmetries between the effects on the global carbon system of El Niño and La Niña events. The calendar-year timing differs; La Niña changes in atmospheric CO2 typically occur primarily over September–May, while El Niño changes occur primarily over December–August. And the net concentration change is quite different; La Niña changes are about half the size of El Niño changes. These results illustrate new aspects of the ENSO/global carbon budget interaction and provide useful global-scale benchmarks for the evaluation of Earth System Model studies of the carbon system.
Prevalence, Determinants, and Misclassification of Myocardial Infarction in the Elderly

We evaluated the prevalence, determinants, and misclassification of different types of myocardial infarction in 3,272 men and women age 55 years or older. We defined self‐reported myocardial infarction with electrocardiographic evidence as “typical myocardial infarction. ” We defined self‐reported myocardial infarction without electrocardiographic evidence, but verified with additional clinical information, as “non‐Q‐wave myocardial infarction. ” Finally, we defined myocardial infarction detected by electrocardiogram that was not self‐reported as “silent myocardial infarction,” after verification of absence of symptoms. Overall, the prevalence of typical myocardial infarction was 4.1% [95% confidence interval (CI) = 3.5–4.9], of non‐Q‐wave myocardial infarction 2.8% (95% CI = 2.2–3.4), and of silent myocardial infarction 3.9% (95% CI = 3.2–4.5). Silent myocardial infarction was more prevalent in women, hypertensives, cigarette smokers, and those with higher post‐load blood glucose. Self‐reported myocardial infarction without electrocardiographic characteristics could be verified as myocardial infarction by means of additional clinical information in 56% of the cases. We conclude that myocardial infarction occurs frequently in the elderly without typical symptoms or electrocardiographic changes. As all these manifestations of myocardial infarction convey an increased risk of symptomatic heart disease or death, they require further attention. Misclassification due to limited sources of information can be considerable and should be taken into account in the design and interpretation of epidemiologic studies.
Coefficient inaccuracy effects in recursive analog sampled-data filters

The coefficient inaccuracy effects in the frequency response of discrete-time recursive transfer functions are investigated. After describing these inaccuracies as additive zero-mean Gaussian random variables, new analytic expressions for the deviation in the frequency response of recursive sampled-data filters are derived through a statistical analysis. Also obtained is an estimate of the actual magnitude of the filter frequency response. Results obtained through computer simulations using the Monte Carlo technique are compared to the proposed approach in order to give support to the developed analysis. <<ETX>>
Parallelization of Healthcare Monitoring Algorithm based on Hardware Accelerator and Wearable Sensor

This work is to design an effective monitoring algorithm for healthcare services. By collecting physiological and physical sensors data, monitoring algorithms can provide various services in healthcare area, however, most of them have to face the difficulty of large amount of sensor data and complicated computation. Regular approaches are based on sequential computing that is not suitable. We propose an approach that involves parallel computing with the advantages of hardware accelerator and by maximizing the parallelization of algorithms to achieve relatively good performance. We use GPGPUs to work as hardware accelerator and evaluate K Nearest Neighbor algorithm, which has large computational burden and relatively high accuracy. Through maximizing the parallel computational segments of algorithm and optimizing the storage strategy of processing sensor data with the advantages from memory hierarchy of GPGPUs, we provide a relative good performance improvement, both of the running speed of KNN algorithms and the size of sensor data waiting for processing. In the experiment, the proposed approach achieved 48x speed up rather than select sort based approach and at most 14x speed up rather than bitonic sort based approach when using large size of training data. With the performance improvement from the parallelization, it could help to optimize the healthcare services based on wearable devices and embedded system in the future. Keywords— Healthcare Monitoring algorithm; k nearest neighbors; Parallel computing; GPUand OpenCL based k-NN; Wearable sensors data; Parallel radix sort;
Development of a methodology to forecast time series using few input variables

This paper aims to develop a methodology for choosing the inputs of a multilayer fuzzy inference system to forecast time series power demand values in a substation feeder. The forecast is done by analyzing past time series data. On an iteration process, older data with greater correlation with the previous forecast errors are the inputs of the fuzzy system, which has as output a future demand value. It is attempted to estimate the largest possible horizon reaching the minimum forecast error. The obtained results are satisfactory, showing that the developed methodology is capable of picking a small number of inputs to forecast with accuracy different horizons. Thus, it is intended that this paper can generate contributions in the fields of intelligent systems, dynamical systems and electricity market.
North American water and energy cycles

Closure of the water and energy cycles for North America has been improved by combining several new data sets to provide an integrated view from 1979 to 2010. We use new global atmospheric reanalyses, top‐of‐atmosphere radiation, surface fluxes including evaporation E and precipitation P, streamflow and river discharge, and Gravity Recovery and Climate Experiment estimates of water storage and its tendency. The atmospheric moisture budget provides more reliable estimates and reproducible time series of E‐P than separate estimates of E and P. The excess of P over E is greatest in winter largely because of changing evapotranspiration, whereas precipitation is largest in summer. The annual mean loss of energy to space of 33 W m‐2 is compensated for nearly equally by transports of dry static energy and latent energy onto land. The annual cycle (amplitude of ~20 W m‐2) of implied downward surface flux corresponds to changes in surface and soil temperatures and seasonal snowmelt.
Kinematic feedback control laws for generating natural arm movements

We propose a stochastic optimal feedback control law for generating natural robot arm motions. Our approach, inspired by the minimum variance principle of Harris and Wolpert (1998 Nature 394 780–4) and the optimal feedback control principles put forth by Todorov and Jordan (2002 Nature Neurosci. 5 1226–35) for explaining human movements, differs in two crucial respects: (i) the endpoint variance is minimized in joint space rather than Cartesian hand space, and (ii) we ignore the dynamics and instead consider only the second-order differential kinematics. The feedback control law generating the motions can be straightforwardly obtained by backward integration of a set of ordinary differential equations; these equations are obtained exactly, without any linear–quadratic approximations. The only parameters to be determined a priori are the variance scale factors, and for both the two-DOF planar arm and the seven-DOF spatial arm, a table of values is constructed based on the given initial and final arm configurations; these values are determined via an optimal fitting procedure, and consistent with existing findings about neuromuscular motor noise levels of human arm muscles. Experiments conducted with a two-link planar arm and a seven-DOF spatial arm verify that the trajectories generated by our feedback control law closely resemble human arm motions, in the sense of producing nearly straight-line hand trajectories, having bell-shaped velocity profiles, and satisfying Fitts Law.
The complete chloroplast genome of the essential medicinal herb, Amomum Villosum (Zingiberaceae)

Abstract Amomum villosum Lour. is a medicinal herb of high economic value, which is endemic to southern China. The size of A. villosum chloroplast (cp) genome was 163,733 bp long, which consisted of long (LSC; 88,798 bp) and short (SSC; 15,353 bp) single-copy regions, separated by a pair of inverted repeats (IRs; 29,791 bp for each unit). Totally, 126 genes are annotated in the cp genome, including 88 protein-coding genes (PCGs), 30 transfer RNA genes (tRNAs), and 8 ribosomal RNA genes (rRNAs). The overall GC content is 36.1%. The phylogenetic analysis based on 43 conserved protein-coding genes from 32 plant species recovered a consistent phylogeny on most of the nodes with previous results and indicated A. villosum as the sister species of the common ancestor of A. compactum and A. krervanh, and suggested that the cp genome data can effectively resolve the phylogenetic relationships. Our study provides a valuable resource for further study on its genetic diversification, evolution and germplasm conservation of this valued medicinal plant.
Barthel Index in a Middle-East Country: Translation, Validity and Reliability

Background: In Iran, a Middle-East country, no disability scale has been translated and validated for use in stroke clinical trials. This study was designed to translate the Barthel Index and make its Persian translated form valid and reliable. Methods: All items of the Barthel Index were translated into Persian. Also, the Modified Rankin Scale (MRS) was also translated to Persian. Telephone interview was used as the method of data acquisition. Two interviewers were chosen for this means in order to accelerate data gathering and measure interrater agreement. Samples were selected from Isfahan Cardiovascular Research Center’s Stroke Registry Unit, a WHO collaborating center in the center of Iran. All the patients were registered as stroke or intracerebral hemorrhage (ICH). These patients were inhabitants of Isfahan Province who had suffered from stroke or ICH between 12 and 24 months before data acquisition. Chronbach’s alpha, test-retest reliability, concurrent validity with MRS, interrater agreement and item analysis were done for the translated questionnaire. Results: Translated questionnaires were filled by interview from 459 stroke patients. Their mean age was 68.11 ± 11.59 years. 243 of them were male (52.9%). Cronbach’s alpha was 0.9354. Spearman’s correlation coefficient between translated Barthel Index scores and MRS scores was –0.912. Spearman’s correlation coefficient between 2 scores, to determine test-retest reliability was 0.989. Concordance correlation to determine interrater agreement was 0.994. All corrected item–total correlations were greater than 0.5. Conclusions: The Persian translated version of the Barthel Index is a reliable and valid questionnaire for use in stroke clinical trials.
An examination on RFID innovation diffusions in Chinese public intelligent transportation services

Radio frequency identification RFID has been widely used in not only industries but also public services. As a typical application of RFID, the electronic toll collection ETC has great contributes to public transportation services, especially in the developing countries. This study developed a research model based on innovation diffusion theory to identify critical factors impacting the RFID adoption intention in public services. Specifically, it investigated the correlations of perceived characteristics of innovation PCI, communication channels and government polices with adoption intentions. In total, 180 valid survey datasets of ETC users in China were obtained. The partial least squares structural equation modelling SEM was used to analyse the model. The results indicated that the PCI were significant in impacting RFID adoptions. Communication channels had a strong influence on people's perceived relative advantages. A moderate effect of government policies was also found. The theoretical and practical implications were presented later.
Cascaded three-level inverter based shunt active filter for power conditioning application

In past few years, multilevel inverters have shown considerable advantages over traditional two-level inverters in a majority of the high power high voltage and medium voltage industrial applications. As a consequence, the cascaded multilevel inverter (CMI) configuration has grabbed tremendous interest in the power industry. Now-a-days, with the increasing usage of power electronic devices by industrial, commercial and domestic consumers, power quality is deteriorating at a rigorous pace. In this paper, a cascaded three-level inverter based shunt active power filter (APF) has been modeled in order to handle large compensation currents and reduce the power loss occurring due to switching of semiconductor devices. Current harmonics produced due to a non-linear diode rectifier load is compensated using the three-level inverter based APF. An evaluation is carried out with MATLAB/Simulink based simulations to investigate its current harmonic compensation capability under ideal, distorted and unbalanced supply conditions.
Widening clinical applications of the SYNTAX Score

The SYNTAX Score (http://www.syntaxscore.com) has established itself as an anatomical based tool for objectively determining the complexity of coronary artery disease and guiding decision-making between coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI). Since the landmark SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) Trial comparing CABG with PCI in patients with complex coronary artery disease (unprotected left main or de novo three vessel disease), numerous validation studies have confirmed the clinical validity of the SYNTAX Score for identifying higher-risk subjects and aiding decision-making between CABG and PCI in a broad range of patient types. The SYNTAX Score is now advocated in both the European and US revascularisation guidelines for decision-making between CABG and PCI as part of a SYNTAX-pioneered heart team approach. Since establishment of the SYNTAX Score, widening clinical applications of this clinical tool have emerged. The purpose of this review is to systematically examine the widening applications of tools based on the SYNTAX Score: (1) by improving the diagnostic accuracy of the SYNTAX Score by adding a functional assessment of lesions; (2) through amalgamation of the anatomical SYNTAX Score with clinical variables to enhance decision-making between CABG and PCI, culminating in the development and validation of the SYNTAX Score II, in which objective and tailored decisions can be made for the individual patient; (3) through assessment of completeness of revascularisation using the residual and post-CABG SYNTAX Scores for PCI and CABG patients, respectively. Finally, the future direction of the SYNTAX Score is covered through discussion of the ongoing development of a non-invasive, functional SYNTAX Score and review of current and planned clinical trials.