Miracle-dz/UniFAR-FTUs huggingface dataset:
SAWSDL Service Discovery Based on Fine-Grained Data Semantics

With the aim to improve the effectiveness of SAWSDL service discovery, this paper proposes a novel discovery method for SAWSDL services, which is based on the matchmaking of so-called fine-grained data semantics that is defined via sets of atomic elements with built-in data types. The fine-grained data semantics can be obtained by a transformation algorithm that decomposes parameters at message level into a set of atomic elements, considering the characteristics of SAWSDL service structure and semantic annotations. Then, a matchmaking algorithm is proposed for the matching of fine-grained data semantics, which avoids the complex and expensive structural matching at the message level. The fine-grained data semantics is transparent to the specific data structure of message-level parameters, therefore, it can help to match successfully similar Web services with different data structures of parameters. Moreover, a comprehensive measure is proposed by considering together several important components of SAWSDL service descriptions at the same time. Finally, this method is evaluated on SAWSDL service discovery test collection SAWSDL-TC2 and compared with other SAWSDL matchmakers. The experimental results show that our method can improve the effectiveness of SAWSDL service discovery with low average query response time. The results imply that fine-grained parameters fit to represent the data semantics of SAWSDL services, especially when data structures of parameters are not important for semantics.
Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462.

Cytochrome P450scc (P450scc) catalyzes the first step in steroid hormone synthesis, the conversion of cholesterol to pregnenolone. Human P450scc has been poorly studied due to the difficulty of purifying reasonable quantities of enzyme from human tissue. To provide a more convenient source of the human enzyme and to enable structure-function studies to be done using site-directed mutagenesis, we expressed the mature form of human P450scc in Escherichia coli. The expression system enabled us to produce larger quantities of active cytochrome than have previously been isolated from placental mitochondria. The expressed P450scc was purified to near homogeneity and shown to have catalytic properties comparable to the enzyme purified from the human placenta. The mature form of human adrenodoxin was also expressed in E. coli and supported cholesterol side chain cleavage activity with the same Vmax as that observed using bovine adrenodoxin but with a higher Km. Mutation of Ile-462 to Leu in human P450scc caused a decrease in the catalytic rate constant (kcat) with cholesterol as substrate, increased the Km for 22R-hydroxycholesterol, but did not affect the kinetic constants for 20 alpha-hydroxycholesterol. This suggests that Ile-462 lies close to the side chain binding site and that the side chains of cholesterol, 22R-hydroxycholesterol, and 20 alpha-hydroxycholesterol occupy slightly different positions in the active site.
Human Action Recognition with Attribute Regularization

Recently, attributes have been introduced to help object classification. Multi-task learning is an effective methodology to achieve this goal, which shares low-level features between attribute and object classifiers. Yet such a method neglects the constraints that attributes impose on classes which may fail to constrain the semantic relationship between the attribute and object classifiers. In this paper, we explicitly consider such attribute-object relationship, and correspondingly, we modify the multi-task learning model by adding attribute regularization. In this way, the learned model not only shares the low-level features, but also gets regularized according to the semantic constrains. Our method is verified on two challenging datasets (KTH and Olympic Sports), and the experimental results demonstrate that our method achieves better results than previous methods in human action recognition.
Extending IP-MAPS: Incorporating the Event-Driven Process Chain Methodology

This paper takes the basic constructs of the IP-Map diagram and demonstrates how they can be rearranged into a family of diagrams based on the Event-Driven Process Chain Methodology. This family of diagrams can be used to fully describe the organizational, procedural, informational, and communication structure of a business process while at the same time highlighting the information products used by that business process. The paper concludes with a review of requirements for a software package that will allow analysts to model and explore their business processes with an emphasis on improving the quality of the organization's information products.
Didactique de l’écriture, didactique du français : vers la cohérence configurationnelle

Tres riche, la didactique de l'ecrit (DDE) est composite, voire heteroclite. La DDE actuelle est le point d'aboutissement du mouvement de renovation, dans ses aspects didactique et pedagogique. En l'etat, elle fournit au mieux des savoirs a l'usage d'enseignants bien formes susceptibles de « bricoler » avec efficacite. La pedagogie de l'ecrit, les mises en oeuvre de projets et de situations de production, ont semble-t-il plus d'effets positifs sur les performances ecrites que les savoirs didactiques proprement dits. Multidimensionnelle, la didactique de l'ecrit designe un champ de preoccupations heterogenes et n'atteint pas les resultats escomptes en termes de savoir faire. L'echec en ecrit (lecture / ecriture) est toujours l'echec majeur en enseignement du francais. Au moment ou la matiere francais se reconfigure, cf. les recentes I. O. pour l'elementaire, la DDE gagnerait a cerner ses savoirs et a les organiser en enseignables-programmables dans le fil langue, texte, discours. En meme temps, la DDE devrait se re equilibrer fondamentalement et prendre paradigmatiquement en compte le fait que l'ecrit (litteraire) de fiction – horizon determinant jusqu'ici – ne peut plus etre la seule reference de la pratique de l'ecrit.
Capitalisation pérenne de connaissances industrielles : vers des méthodes de conception incrémentales et itératives centrées sur l'activité . (Long-term capitalization of corporate knowledge : towards incremental and iterative activity centered design methods)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Capitalisation pérenne de connaissances industrielles : Vers des méthodes de conception incrémentales et itératives centrées sur l’activité Carine Toure
Use of the Child Health Questionnaire in a Sample of Moderate and Low‐Income Inner‐City Children with Asthma.

The Child Health Questionnaire (CHQ-PF50) is one of several recent efforts to gauge pediatric, health-related quality of life from the patient's (or parent's) perspective. Although tested extensively with healthy children, more information is needed about CHQ performance among children with chronic conditions such as asthma. The current study extends previous work by examining the CHQ's psychometric performance in a sample of children with asthma, overrepresenting those at high risk for poor outcomes. Seventy-four adult caregivers of children with asthma completed the CHQ. Internal consistency reliability was consistently high for all but one scale. Intraclass correlation coefficients ranged from a low of 0.37 to a high of 0.84. Tests of validity found CHQ scales better at distinguishing levels of disease severity as defined by symptom activity than medication use or pulmonary function tests. Performance of the CHQ-PF50 in a sample of low-income to moderate income inner-city parents of children with asthma presented mixed results. The instrument addresses a broad range of concepts but some scales may be more salient than others in assessing health status of children at highest risk for asthma morbidity. Future efforts must compare condition-specific and generic instruments to evaluate their relative strengths and weakness, as well as potential links between them.
The complete mitochondrial genome of Cervus elaphus kansuensis (Artiodactyla: Cervidae) and its phylogenetic analysis

Abstract Gansu wapiti (Cervus elaphus kansuensis) is one of eight subspecies of wapiti in China, which has been placed under the second-ranked protected animals by Chinese government. No complete mitochondrial genomes of Gansu wapiti was determined until now, so the phylogenetic relationships among the subspecies of wapiti and other species of the genus Cervus have not been well studied. In this study, the complete mitochondrial genome of C. e. kansuensis was first sequenced and characterized. The genome is 16,430 bp in length, containing 13 protein-coding genes (PCGs), 22 transfer RNA (tRNA) genes, two ribosomal RNA (rRNA) genes, and one noncoding control region (CR). Maximum-Likelihood (ML) and Bayesian Inference (BI) trees based on the 13 PCGs show that C. e. kansuensis is clustered with other wapiti subspecies in China except for C. e. yarkandensis. It is also shown that Cervus elaphus is not a monophyletic group. This study provides important molecular evidence for the phylogenetic relationship among species in the genus Cervus.
Impact of Radial defect clustering on 3D stacked IC yield from wafer to wafer stacking

We present and evaluate a simulation methodology to model the impact of the radial clustering of defects on wafers on the yield of 3D ICs manufactured using wafer to wafer stacking. Our simulations draw on an extensively validated model for radial yield degradation on wafers from the literature to incorporate the effect of this key contributor to the widely observed clustering of defects on semiconductor wafers. Current 3D-SIC yield estimation methods ignore defect clustering and assume a uniform distribution of defective dies on each wafer. Our results show that the radial clustering of defective dies causes stacked die yields to be significantly higher than that projected by current models. For 4-5 layer stacks the difference can be 50% or more. Our simulation studies are further validated by comparison with actual silicon data, which suggests that even the more accurate yield estimates from our improved methodology may be somewhat pessimistic. Thus the results presented here show that in practice degradation in stacked die yield from compounding may not be as severe as commonly estimated. This has significant implications in evaluating cost trade-offs associated with 3D-SIC manufacturing.
Click here Terms of use : Click here Self-perception but not peer reputation of bullying victimization is associated with non-clinical psychotic experiences in adolescents

Psychological Medicine / Volume null / Issue 04 / April 2013, pp 781 787 DOI: 10.1017/S003329171200178X, Published online: 16 August 2012 Link to this article: http://journals.cambridge. org/abstract_S003329171200178X How to cite this article: P. M. Gromann, F. A. Goossens, T. Olthof, J. Pronk and L. Krabbendam (2013). Self-perception but not peer reputation of bullying victimization is associated with non-clinical psychotic experiences in adolescents. Psychological Medicine, null, pp 781-787 doi:10.1017/S003329171200178X Request Permissions : Click here
Reducing the complexity of visual navigation: Optical track controller for long‐range unmanned aerial vehicles

Using vision for navigation of airborne systems provides an opportunity for motion relative to the ground to be controlled in the absence of other supporting sensors including global navigation satellite systems. Rather than relying on computationally intensive localization techniques such as online map construction, identification and tracking of landmarks, or otherwise producing an explicit quantitative estimate of position, we propose and have experimentally demonstrated a closed‐loop visual navigation reflex which we term the optical ground course controller. The behavior is applicable to fixed wing aircraft traversing long ranges, and reduces the online computation and sensors required compared to other visual methods. This method combines the kinematics of fixed wing aircraft flight, the direction of apparent motion of an image sequence, and a magnetic compass to create a bioinspired optomotor reflex similar to those observed in insects. This behavior accurately controls track in the inertial reference frame (path taken over the ground) with only limited dependence on altitude, speed, and wind. We show that the proposed behavior is naturally convergent and stable, and present experimental results from simulation and real‐world flight demonstrating that the method performs robustly, producing improvement over both magnetic‐referenced and visual odometry‐based navigation within the limits of the sensor.
Inhibition of Bacterial Multidrug Resistance by Celecoxib, a Cyclooxygenase-2 Inhibitor

ABSTRACT Multidrug resistance (MDR) is a major problem in the treatment of infectious diseases and cancer. Accumulating evidence suggests that the cyclooxygenase-2 (COX-2)-specific inhibitor celecoxib would not only inhibit COX-2 but also help in the reversal of drug resistance in cancers by inhibiting the MDR1 efflux pump. Here, we demonstrate that celecoxib increases the sensitivity of bacteria to the antibiotics ampicillin, kanamycin, chloramphenicol, and ciprofloxacin by accumulating the drugs inside the cell, thus reversing MDR in bacteria.
High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells.

BACKGROUND In response to chronic hyperglycemia, microvascular cells undergo stress and injury, which can lead to cell death. We characterized a proapoptotic signaling pathway whereby high glucose evokes an intrinsic, caspase-9-dependent mechanism of cell death in human mesangial cells. METHODS Biochemical (caspase activity, cytochrome-c release, etc.) and morphologic (chromatin condensation and nuclear segmentation) features of apoptotic cell death were assessed in cultured human mesangial cells exposed to high glucose, a risk factor for mesangial cell injury and diabetic glomerulosclerosis. Proapoptotic signaling was also analyzed in the db/db murine model of kidney injury in diabetes. RESULTS Incubation in high glucose caused cytotoxicity and apoptosis in mesangial cells. High glucose stimulated mitochondrial release of cytochrome-c, cleavage of procaspase-9, and caspase-9 enzyme activity, suggesting an intrinsic pathway of proapoptotic signaling. In contrast, caspase-8 was unaffected by high glucose. A cell-permeable, caspase-9-selective inhibitor blocked caspase-3 activation and prevented chromatin condensation and nuclear segmentation in cells treated with high glucose. To determine whether an intrinsic signaling pathway occurs in the diabetic kidney in vivo, apoptosis was investigated in diabetic 8- and 16-week db/db murine kidneys. Effector caspases-3 and -7 were activated in diabetic db/db kidneys but not in age-matched nondiabetic db/m controls. At 16 weeks, apoptotic cells in db/db glomeruli were identified on the basis of nuclear segmentation and DNA fragmentation. Apoptosis of glomerular cells correlated with expansion of the mesangial matrix and with worsening of albuminuria. Consistent with an intrinsic signaling pathway, caspase-9 cleavage was elevated only in db/db kidneys, whereas activation of caspase-8 and caspase-12 was undetectable. CONCLUSION These findings support the hypothesis that hyperglycemia evokes an intrinsic pathway of proapoptotic signaling in mesangial cells. In addition, these results point to an important role for the intrinsic pathway in microvascular injury in the diabetic kidney in vivo.
Nonlinear pseudo-measurement filtering for in-orbit bearings-only navigation

In-orbit rendezvous is a key enabling technology for many space missions that already enjoys significant heritage. However, complex hardware is generally required in order to measure the relative range. Achieving rendezvous employing only bearing/angle measurements would simplify the relative navigation hardware currently required, increasing robustness and reliability by reducing complexity, launch mass, and cost. The problem of bearings-only navigation has been intensively studied by the naval and military communities. Several authors have discussed the robustness and stability advantages of pseudomeasurement filters in two dimensions, where the nonlinear measurement equation is recast in a linear form with respect to the states. Motivated by these potentials, this work explores its extension into three-dimensional space, when the complexity of the measurement equations makes it impossible to directly apply existing formulations. In this paper, the three-dimensional measurement equation is recast using pseudomeasurements with a multiplicative noise term, and an optimal filter suited for this pseudomeasurement structure is developed. Finally, the resulting bearings-only pseudomeasurement filter is implemented for the case of in-orbit relative navigation. Monte Carlo simulations show this filter exhibits far superior performance and robustness when initialization errors are significant, compared to a traditional extended Kalman filter implementation.
Rhinovirus and the initiation of asthma

Purpose of reviewVirus-induced wheezing in infancy is a risk factor for asthma, and recent studies have highlighted the role of rhinoviruses in causing acute illnesses and as a possible contributing factor to chronic asthma. Recent findingsHuman rhinoviruses (HRVs) have long been known as the most common cause of common cold in infants and children. Recent developments in molecular diagnostics have led to the discovery of new viruses and have also provided data to implicate HRV as an important cause of lower respiratory infections and acute virus-induced wheezing in preschool children. In addition, HRV-induced wheezing episodes appear to identify children who are at increased risk for the subsequent development of childhood asthma. SummaryCollectively, these findings raise the possibility that lower respiratory infections with pathogens such as HRV and respiratory syncytial virus could participate in the causation of asthma, especially in children with suboptimal antiviral defenses. A variety of experimental models and clinical studies have been used to identify possible mechanisms related to the infection and the ensuing host response that could disturb normal lung and immunologic development to promote asthma. Defining these relationships could lead to new therapeutic and preventive approaches to common forms of childhood asthma.
Distribuição da renda agrícola e sua contribuição para a desigualdade de renda no Brasil

Inicialmente, ressalta-se a importância de nao confundir a ocupacao agricola com a residencia rural. Em seguida, analisa-se a distribuicao da posse da terra entre empreendimentos agricolas, com base na Pesquisa Nacional por Amostra de Domicilios (PNAD), de 2009. No terceiro topico, analisa-se a distribuicao do rendimento de todos os trabalhos entre pessoas com ocupacao principal na agricultura, comentando-se a evolucao das principais caracteristicas dessa distribuicao, de 1995 a 2009. No quarto topico, estimam-se as equacoes de rendimento, incluindo-se como variaveis explanatorias a area de terra do empreendimento agricola para os conta propria e os empregadores, e o fato de a pessoa ser ou nao proprietaria da terra. No ultimo topico, verifica-se como a renda agricola contribui para o elevado grau de desigualdade que caracteriza a distribuicao da renda domiciliar per capita (RDPC) no Pais. A tecnica estatistica usada e baseada no fato de que, ao se dividir a renda em parcelas, o indice de Gini da RDPC e igual a uma media ponderada das razoes de concentracao de cada parcela. Verifica-se que a renda agricola e uma parcela progressiva da RDPC, no Brasil. Finalmente, analise-se a contribuicao de varias parcelas para a mudanca na desigualdade da distribuicao da RDPC, no periodo 2002–2009.
Prepared enough to practise? Evaluating a study programme in social work

Summary Following the so-called Bologna reform in Luxembourg, 70 supervisors assessed the knowledge and skills of employees having qualified with a Bachelor’s degree under the recently introduced curriculum in social work and pedagogy. The supervisors were solicited as part of quality assurance regarding the study programme and their assessments were gathered by means of a questionnaire. The University of Luxembourg funded the study. Findings The newly qualified practitioners were evaluated as adequately trained, while the need was highlighted for a better understanding of the process through which beginner practitioners are socialised into the profession. The results furthermore suggest that practice proficiency extensively draws on generic skills of particular relevance to the social professions. Applications The findings prompt a more specific focus on generic skills and their role in developing proficiency during practice placements as well as during the first year of employment. Overall, the study serves as one example of how to evaluate the readiness to practise of newly qualified practitioners in the social professions. The output of such skills assessments could inform on any need for curriculum revision at a local level. With a cross-national and comparative approach, evaluations of this kind could potentially guide any adaptations needed in response to the increasing internationalisation of social problems.
Detection of P 16 ink 4 a in Non-Oro pharyngeal Head and Neck Squamous Cell Carcinoma

The incidence of HPV associated Head and Neck Squamous Cell Carcinoma (HNSCC) is increasing over the past 30 years. It is a growing public health concern. It has been reported that tissues of HPV associated HNSCCs over express p16 INK4a . Therefore p16 INK4a is used as a surrogate marker to detect HPV associated HNSCC. Immunohistochemical detection of p16 INK4a is an easy and simple technique than molecular detection of HPVs. Hence we investigated the presence of p16 INK4a in Non-Oropharyngeal (nasopharynx, hypopharynx and larynx)Squamous Cell Carcinoma (Non-OPSCC). Aims :The objectives of our study are (1)To study the association of p16 INK4a expression with Non-OPSCC, thus with the HPV. (2)To compare the p16 INK4a expression in different subsites of the Non-OPSCC. (3)To correlate the level of p16 INK4a expression with different grades of Non-OPSCC. Materials and methods :A total sample of 25 cases were analysed during the period of June 2014 toAugust 2015. We performed IHC in sections of formalin fixed paraffin embedded tissue of Non-OPSCC cases and correlated the various patterns of p16 INK4a positivity with respect to histopathological diagnosis. Results :In the present study, 80.00% of the Non-OPSCC cases were above 50 years of age. Non-OPSCC was more common in males with male to female ratio of 4:1 . 92.00% of Non-OPSCC cases were positive for p16 INK4a , of which the most common pattern was diffuse nuclear and cytoplasmic staining (76.00%). Conclusion :In the present study, increased number of Non-OPSCC cases was seen over expressing p16 INK4a (92.00%). Hypopharynx was the commonest site for p16 INK4a positivity (92.30%). Of the Non-OPSCC cases, most cases (76.00%) had diffuse pattern of p16 INK4a over expression. However, DNA detection based studies are needed to validate the utility of IHC detection of p16 INK4a as a surrogate marker for HPV associated HNSCC.