Miracle-dz/UniFAR-FTUs huggingface dataset:
Sentinel lymph node detection in patients with early cervical cancer.

INTRODUCTION Lymph node status is the most important independent prognostic factor in early stage cervical cancer. Intraoperative lymphatic mapping and sentinel lymph node detection have been increasingly evaluated in the treatment of a variety of solid tumors, particularly breast cancer and cutaneous melanoma. This study evaluated the feasibility of these procedures in patients undergoing radical hysterectomy with pelvic lymphadenectomy for early cervical cancer. METHODS A total of 30 patients with histologically diagnosed FIGO stage IA to IIA cervical cancer were enrolled to this study. They were scheduled to undergo radical abdominal hysterectomy and pelvic lymphadenectomy after injecting patent blue dye in cervix. RESULTS A total of 60 SLNs (mean 2.5) were detected in 24 patients with detection rate of 80%. Bilateral SLNs were detected in 70.1% of cases. SLNs were identified in obturator and external iliac areas in 50% and 31.7%, respectively; no SLNs were discovered in the common iliac region. Seven patients (23.3%) had lymph node metastases; one of these had false negative SLN.The false negative rate and negative predictive value were 14.3% and 94.4%, respectively. CONCLUSIONS SLN detection procedure with blue dye technique is a feasible procedure in cervical cancer. Patent blue dye is cheap, safe and effective tracer to detect sentinel node in carcinoma of cervix.
Obesity and Diabetes Mellitus Adversely Affect Outcomes after Cardiac Surgery in Children's Hospitals.

OBJECTIVE To assess how obesity or diabetes mellitus impacts outcomes in patients undergoing cardiac surgery in pediatric hospitals. DESIGN A multi-institutional, matched case-control study of the Pediatric Health Information System database was performed. SETTING Tertiary children's hospitals in the United States. PATIENTS All cardiac surgical cases in patients with obesity or diabetes mellitus between 2004 and 2012 were included. Cases were matched to controls by age, sex, race, and Risk Adjustment for Congenital Heart Surgery score. OUTCOME MEASURES Mortality, surgical complications, and hospital utilization. Differences in outcome measures were assessed by chi-square and Mann-Whitney tests. P value < . 05 was significant. RESULTS Six hundred twenty-nine cardiac surgical cases (median age 17 years [IQR 12-32]) with obesity or diabetes mellitus were matched to 629 controls. Cases demonstrated lower median household income than those in the control group ($38,031 [IQR $31,900-$48,844] vs. ($41,896 [IQR $32,854-$56,020], P < .001). Mortality was similar between cases and controls (22% vs. 1.9%, P =.692). Surgical complications occurred similarly between cases and controls (13.5% vs. 12.4%, P = .535). Cases had longer intensive care unit length of stay than controls (3 vs. 2 days, P = .001), resulting in longer overall hospital length of stay (5 vs. 4 days, P < .001). Cases also had a higher odds of undergoing mechanical ventilation for >96 hours (OR 2.0, 95% CI 1.1-3.7) and higher rate of total parenteral nutrition use (7.2% vs. 4.5%, P = .040). Median hospital charges were higher in cases (clinical: $6,696 vs. $5,872; laboratory: $14,168 vs. $12,251; pharmacy: $12,971 vs. $10,426; imaging: $6,259 vs. $5,660; P ≤ .030 for all). CONCLUSIONS The presence of obesity or diabetes mellitus was associated with increased postoperative morbidity, hospital utilization, and cost in patients undergoing cardiac surgery in pediatric hospitals.
EUV light source by high power laser

In the development of an efficient, clean and high power EUV source, it is important to understand basic physics of EUV plasma and to optimize laser and target conditions. Our program aims at constructing database on EUV radiation from the laser-produced plasma by the theoretical and experimental studies, and providing technical guidelines for the practical EUV source used in the EUV lithography system. Recent progresses of our program will be presented.
The first description of oarfish ( Regalecus russellii Cuvier 1816) (Regalecidae) ageing structures

The first description of oarfish (Regalecus russellii Cuvier 1816) (Regalecidae) ageing structures By S. R. Midway and T. Wagner Pennsylvania Cooperative Fish and Wildlife Research Unit, Pennsylvania State University, University Park, Pennsylvania, USA; U.S. Geological Survey, Pennsylvania Cooperative Fish and Wildlife Research Unit, Pennsylvania State University, University Park, Pennsylvania, USA
Effect of diesel leakage in circulating cooling water system on preponderant bacteria diversity and bactericidal effect of biocides

Petroleum products leakage results in adverse effect on the normal operation of a circulating cooling water system. However, relatively little research has been done to explore the effect of petroleum products leakage on circulating cooling water quality and biofilm preponderant bacteria diversity. Also, normal biocides application modes cannot fulfil the need for biofilm control. In this study, diesel oil was used as the experimental subject representing leaking petroleum products; the effect of diesel addition on biofilm preponderant bacteria diversity and the bactericidal effect of chlorine dioxide and tetradecyl dimethyl benzyl ammonium chloride (1427) was investigated. Bacterial community structures were examined by PCR-denaturing gradient gel electrophoresis and PCR cloning of 16S rDNA genes. Except for 100 mg/L diesel, increasing diesel concentration enhanced the biofilm detachment ratio compared with the control test. The microstructure of biofilm samples with 0, 300 and 900 mg/L diesel addition was observed. The species of preponderant bacteria in the biofilm sample with 300 mg/L diesel addition were more and the bacterial distribution was more uniform than those in the biofilm sample with 900 mg/L diesel addition. With ClO2 and 1427 addition, chemical oxygen demand increased, lipid phosphorus and bacterial count first decreased and then remained stable, and the bactericidal ratio first increased and then remained stable. Diesel addition variation has more obvious effect on ClO2 than 1427.
Optimal enrichment time for isolation of Vibrio parahaemolyticus from seafood

The growth of Vibrio parahaemolyticus in a liquid medium was compared with that of human fecal flora and estuarine flora. No marked differences were noted between growth at 25 and 37 degrees C for V. parahaemolyticus. However, the marine organisms were strongly inhibited when incubated at 37 degrees C. Incubation for 8 h in an enrichment broth yielded V. parahaemolyticus growth, even with a small inoculum, whereas the marine and fecal floras were inhibited. Therefore, enrichment for 8 h at 37 degrees C appears to be optimal for isolation of V. parahaemolyticus, permitting more rapid results in seafood analysis.
Municipality attraction and commuter mobility in urban Sweden: An analysis based on longitudinal population data

At the individual level, commuting can be seen as part of a search process that may lead to adjustments in terms of migration or change of workplace. The behaviour of commuters is affected by individual characteristics and factors related to housing, labour and transport markets. It can provide insight into factors related to different municipalities’ levels of attraction. In our study, we provide a longitudinal analysis of individual commuting behaviour during a one-year study period: we simultaneously address the dynamics of ending commuting by a migration event, a change of workplace, or both. Our study is situated in the urban region that surrounds lake Mälaren of Sweden, including its capital Stockholm. We draw on unique register data on the entire commuter population of that region and linked contextual data on the characteristics of the municipalities where the commuters live and work. Migration rates are strongly related to demographic variables, whereas the propensity to change workplace mainly varies with economic variables. We demonstrate that the attraction of a municipality in terms of residence increases with the general accessibility to workplaces and decreases with its level of housing prices. An increased supply of new dwellings in a municipality has a greater impact on the capacity to increase its population than has an increased supply of workplaces.
The relationships of Odontotrema (Odontotremataceae) and the resurrected Sphaeropezia (Stictidaceae)—new combinations and three new Sphaeropezia species

Odontotremataceae is polyphyletic and constitutes two distantly related clades, the true Odontotremataceae and a segregate group within Stictidaceae including “Odontotrema” cassiopes, “O. ” diffindens, lichenicolous “Odontotrema” species and “Bryodiscus” arctoalpinus. Sphaeropezia here is accepted as the name for this latter group. An updated phylogeny of the Stictidaceae based on mtSSU, nuLSU and the protein coding gene RPB2 is presented together with a taxonomic revision of Swedish taxa of Odontotrema and Sphaeropezia. Bryodiscus and Lethariicola are synonymized under Sphaeropezia, and three new Sphaeropezia species are described: the lignicolous S. capreae, the fungicolous S. lyckselensis and the lichenicolous S. mycoblasti. The new species are distinguished from other species by molecular and morphological characters, and substrate preferences. The new combinations Sphaeropezia arctoalpina, S. cassiopes, S. grimmiae, S. hepaticarum, S. melaneliae, S. ochrolechiae and S. thamnoliae are proposed. The morphology of these species was studied in detail. We further propose to combine the remaining lichenicolous Odontotrema species, exept O. stereocaulicola, in Sphaeropezia based on their close relationship to the studied lichenicolous taxa. These additional new combinations include Sphaeropezia bryoriae, S. cucularis, S. figulina, S. intermedia, S. japewiae, S. lecanorae, S. navarinoi, S. pertusariae, S. rhizocarpicola, S. santessonii, and S. sipei. A lectotype is designated for the name Odontotrema diffindens Nyl.
VR4D: An Immersive and Collaborative Experience to Improve the Interior Design Process

Ergonomics and spatial constraints are important issues to consider during the design process of limited spaces. In this paper, we present a user-centered methodology for designing a new VR tool for collaborative design and evaluation of limited spaces. The system is composed of two communicating tools: a sketch-based application, and a 3D immersive application. Using this tool, two collaborating users can perform simultaneously two steps of the design process: the sketching phase, and the organization and evaluation of the 3D space. A preliminary evaluation session, conducted with expert designers to assess the usability and the utility of the system, shows its value.
Combinatorial Therapy With Tamoxifen and Trifluoperazine Effectively Inhibits Malignant Peripheral Nerve Sheath Tumor Growth by Targeting Complementary Signaling Cascades

Abstract Chemotherapeutic agents effective against malignant peripheral nerve sheath tumors (MPNSTs) are urgently needed. We recently found that tamoxifen potently impedes xenograft growth. In vitro, tamoxifen inhibits MPNST proliferation and survival in an estrogen receptor–independent manner; these effects are phenocopied by the calmodulin inhibitor trifluoperazine. The present study was performed to establish the mechanism of action of tamoxifen in vivo and optimize its therapeutic effectiveness. To determine if tamoxifen has estrogen receptor–dependent effects in vivo, we grafted MPNST cells in castrated and ovariectomized mice; xenograft growth was unaffected by reductions in sex hormones. To establish whether tamoxifen and trifluoperazine additively or synergistically impede MPNST growth, mice xenografted with neurofibromatosis type 1–associated or sporadic MPNST cells were treated with tamoxifen, trifluoperazine, or both drugs for 30 days. Both monotherapies inhibited graft growth by 50%, whereas combinatorial treatment maximally reduced graft mass by 90% and enhanced decreases in proliferation and survival. Kinomic analyses showed that tamoxifen and trifluoperazine have both shared and distinct targets in MPNSTs. In addition, trifluoperazine prevented tamoxifen-induced increases in serum/glucocorticoid regulated kinase 1, a protein linked to tamoxifen resistance. These findings suggest that combinatorial therapy with tamoxifen and trifluoperazine is effective against MPNSTs because these agents target complementary pathways that are essential for MPNST pathogenesis.
Axonal Regeneration across Long Gaps in Silicone Chambers Filled with Schwann Cells Overexpressing High Molecular Weight FGF-2

Basic fibroblast growth factor (FGF-2) has been shown to enhance the survival and neurite extension of various types of neurons including spinal ganglion neurons. In addition, endogenous FGF-2 and FGF receptors are upregulated following peripheral nerve lesion in ganglia and at the lesion site. FGF-2 protein is expressed in different isoforms (18 kDa, 21 kDa, 23 kDa) and differentially regulated after nerve injury. In the rat we analyzed the regenerative capacity of the high molecular weight (HMW) FGF-2 isoforms (21/23 kDa) to support the regeneration of the axotomized adult sciatic nerve across long gaps. The nerve stumps were inserted into the opposite ends of a silicone chamber resulting in an interstump gap of 15 mm. Silicone tubes were filled with Matrigel or a mixture of Schwann cells (SC) and Matrigel. SC were prepared from newborn rats and transfected to overexpress HMW FGF-2. Four weeks after the operation procedure, channels were analyzed with regard to tissue cables bridging both nerve stumps and myelinated axons distal to the original proximal nerve stump. Peripheral nerves interposed with HMW Schwann cells displayed significantly enhanced nerve regeneration, with the greatest number of tissue cables containing myelinated axons and the highest number of myelinated axons. These results suggest that a cellular substrate together with a source of a trophic factor could be a promising tool to promote nerve regeneration and, therefore, become useful also for a clinical approach to repair long gaps.
Interest Rates And Consumption Volatility: Any Implications For Consumption Smoothing?

The roles of market interest rates in consumption smoothing have been fairly examined; their effects on consumption volatility however in various country groups have received limited attention. This study aims to estimate the effects of these rates on consumption volatility based on data from developed and developing country samples. The General Method of Moments (GMM) and the Two Stage Leas t Squares (2SLS) estimation techniques employed, due to the endogeneity property of the specified model, yield interesting results. Lending rates reduced consumption volatility in developed countries while saving rates did not worsen it. The rates had no effect in developing countries and mixed effects in the whole sample. The rates are relatively lower in developed countries and this partially explains why consumption volatility is lower in developed economies than in developing counterparts. As a result, the developing countries need to implement policies to reduce interest rates as a means of reducing consumption volatility and thus enhance consumption smoothing and maximize their welfare.
An Integrated Control Strategy for a Fast Start-Up and Wide Range Input Frequency Operation of a Three-Phase Boost-Type PFC Converter for More Electric Aircraft

This paper presents an integrated control strategy to achieve fast start-up and enable wide input frequency operation in a three-phase six-switch power factor correction (PFC) converter. Limiting the inrush current with simultaneously minimizing the start-up time is achieved by implementing a nonlinear compensator in the voltage control loop. In addition, the concerning issues regarding unity PFC operation with an accurate reference tracking in a system with wide input frequency variation (typical for more-electric-aircraft) are resolved by a second-order compensator integrated with a state-feedback controller in the current loop. For a proof-of-concept verification, a hardware prototype of 6 kW, three-phase six-switch PFC is developed and tested with the proposed integrated control strategy in a wide source frequency range (360–800 Hz) ac input that shows perfect unity power factor operation throughout. Both the start-up time and inrush current are reduced to $< {\text{50}}\% $ of their values in conventional PI compensation.
RNAseq-based transcriptome analysis of Lactuca sativa infected by the fungal necrotroph Botrytis cinerea.

The fungal pathogen Botrytis cinerea establishes a necrotrophic interaction with its host plants, including lettuce (Lactuca sativa), causing it to wilt, collapse and eventually dry up and die, which results in serious economic losses. Global expression profiling using RNAseq and the newly sequenced lettuce genome identified a complex network of genes involved in the lettuce-B. cinerea interaction. The observed high number of differentially expressed genes allowed us to classify them according to the biological pathways in which they are implicated, generating a holistic picture. Most pronounced were the induction of the phenylpropanoid pathway and terpenoid biosynthesis, whereas photosynthesis was globally down-regulated at 48 h post-inoculation. Large-scale comparison with data available on the interaction of B. cinerea with the model plant Arabidopsis thaliana revealed both general and species-specific responses to infection with this pathogen. Surprisingly, expression analysis of selected genes could not detect significant systemic transcriptional alterations in lettuce leaves distant from the inoculation site. Additionally, we assessed the response of these lettuce genes to a biotrophic pathogen, Bremia lactucae, revealing that similar pathways are induced during compatible interactions of lettuce with necrotrophic and biotrophic pathogens.
New Market Access in Fresh Fruit and Vegetable Imports to the United States

Imports of fresh fruits and vegetables to the United States have grown by more than 350 percent since 1989. Factors such as rising consumer incomes, the desire for greater variety and availability of fresh produce throughout the year, and a reduction in trade barriers through multilateral and bi-lateral trade agreements have contributed to this growth in imports. In addition, since the implementation of the Agreement on Agriculture and the Agreement on the Application of Sanitary and Phytosanitary Measures from the Uruguay Round of the World Trade Organization negotiations, there have been numerous requests to export fresh fruits and vegetables to the United States. From 1996 to 2008, the United States has granted new market access to 204 exporter/commodity combinations. Given this large increase in new market access, this thesis assesses the success of the new entrants in terms of contributing to the increase in fresh fruit and vegetable imports and whether they exported on a continual basis after gaining import eligibility. In addition, this thesis estimates a gravity model to assess the differences in fresh fruit and vegetable exports from new entrants subject to phytosanitary measures relative to those with no such restrictions in place and to determine whether these effects vary by commodity sector and exporter‟s size. The major finding of this thesis is that in general, new entrants have contributed little to the growth in U.S. fresh fruit and vegetable imports. For most commodities, new entrants do not provide a significant proportion of imports potentially because new entrants are not able to compete with existing suppliers. This study finds differences in fresh fruit and vegetable exports from new entrants subject to specific phytosanitary treatments relative to entrants with no such restrictions in place.
Determinants of property rights in Poland and Ukraine: the polity or politicians?

Abstract North (1994) famously remarked that ‘it is the polity that defines and enforces property rights’. This paper traces the development of property rights in Poland and Ukraine and explores their divergence over the past three centuries using North's framework of economic calculation. In each country, the distribution of political power and political institutions had a profound impact on property rights. Indeed, while it was the Polish polity that defined the evolution of property rights from 1386 to 1795 and then from 1989 onward, due to diffusion of power, it was Ukrainian politicians that controlled the destiny of property rights for most of Ukraine's history. This situation has not changed despite the Maidan revolution in Ukraine, and recent moves in Poland show how tenuous property rights are in the face of political opposition.
A Universal operon Predictor for prokaryotic genomes

Identification of operons at the genome scale of prokaryotic organisms represents a key step in deciphering of their transcriptional regulation machinery, biological pathways, and networks. While numerous computational methods have been shown to be effective in predicting operons for well-studied organisms such as Escherichia coli K12 and Bacillus subtilis 168, these methods generally do not generalize well to genomes other than the ones used to train the methods, or closely related genomes because they rely on organism-specific information. Several methods have been explored to address this problem through utilizing only genomic structural information conserved across multiple organisms, but they all suffer from the issue of low prediction sensitivity. In this paper, we report a novel operon prediction method that is applicable to any prokaryotic genome with high prediction accuracy. The key idea of the method is to predict operons through identification of conserved gene clusters across multiple genomes and through deriving a key parameter relevant to the distribution of intergenic distances in genomes. We have implemented this method using a graph-theoretic approach, to calculate a set of maximum gene clusters in the target genome that are conserved across multiple reference genomes. Our computational results have shown that this method has higher prediction sensitivity as well as specificity than most of the published methods. We have carried out a preliminary study on operons unique to archaea and bacteria, respectively, and derived a number of interesting new insights about operons between these two kingdoms. The software and predicted operons of 365 prokaryotic genomes are available at http://csbl.bmb. uga.edu/~dongsheng/UNIPOP.
The Intergenerational Consequences of Tobacco Policy: A Review of Policy's Influence on Maternal Smoking and Child Health

The response of pregnant women to tobacco policy is of particular interest due to these women being in a unique position to pass health capital to the next generation. By comparing estimates in the literature, we highlight that while pregnant women are responsive to taxes and taxes improve child health, their responsiveness has declined over time. We show that these trends reflect a compositional change; specifically, the least addicted smokers quit in the 1990s, leaving the pool of smoking mothers to be dominated by less price elastic smokers. Reviewing the literature on other tobacco policies, we show that a state-level U.S. smoking ban has roughly three times the effect on pregnant women of a 10% increase in prices using elasticity estimates from more recent periods. Throughout this review, we identify areas for improvement in the literature and offer a number of ideas for future research projects.