Miracle-dz/UniFAR-FTUs huggingface dataset:
A Review of Industrial Heat Exchange Optimization

Heat exchanger is an energy exchange equipment, it transfers the heat from a working medium to another working medium, which has been wildly used in petrochemical industry, HVAC refrigeration, aerospace and so many other fields. The optimal design and efficient operation of the heat exchanger and heat transfer network are of great significance to the process industry to realize energy conservation, production cost reduction and energy consumption reduction. In this paper, the optimization of heat exchanger, optimal algorithm and heat exchanger optimization with different objective functions are discussed. Then, optimization of the heat exchanger and the heat exchanger network considering different conditions are compared and analysed. Finally, all the problems discussed are summarized and foresights are proposed.
Reshaping the Macintosh blade using biomechanical modelling#A prospective comparative study in patients

It has been demonstrated that during routine use of the Macintosh blade, great forces are exerted on the maxillary incisors. The aim of this study was, by using biomechanical modelling, to modify a standard Macintosh blade in order to reduce these forces. This resulted in a Macintosh blade with a reduced proximal flange. Five anaesthetists performed tracheal intubation in 46 patients using the modified (n =24) or the standard blade (n = 22). The mean (SD) maximal forces exerted on the maxillary incisors were 12.7 (8.8) N in patients in the modified Macintosh group compared to 25.5 (17.8) N in the standard Macintosh group (p =0.008). These results demonstrate that reducing the proximal step of the Macintosh laryngoscope results in a reduction of the forces exerted on the teeth and suggest that laryngoscope blades with a high proximal step might be more traumatic than blades in which the proximal step is reduced.
Implementation of a smart lab for teachers of novice programmers

Communication between students and their instructors in the lab is a limited commodity. With limited access to the tutor, students can sometimes spend a long time trying to fix simple errors, continually revisiting and repeating the same errors. Instructors, on the other hand, find themselves explaining the same mistakes over and over again. It is often not clear to them how well individual students are progressing toward meeting the task objectives. This paper introduces a new implementation of Smart Classroom technology for introductory programming computer laboratories. The Smart Lab is intended to make the computer lab a better educational environment for both students and instructors. In the Smart Lab instructors are provided with information about each student's progress as they perform programming tasks, enabling the instructors to readily respond to individual student's problems and assess the overall progress of the class. Two different evaluation approaches were used to test the new implementation: an expert review session and a lab study. The evaluation found that the Smart Lab improved instructors understanding of their students' problems enabling them to provide timely and appropriate feedback. It also provided instructors with better understanding of their students' programming strategies and compilation behaviours.
Laps or lengths? The effects of different exercise programs on asthma control in children

ABSTRACT Introduction: Exercise training has been shown in numerous studies to improve lung function and asthma control in children with asthma. Swimming has been shown to be of benefit in children with asthma, but which form of exercise is better for asthmatics has not been determined to date. The aim of this study was to examine if swimming improved lung function and asthma symptoms in asthmatic children when compared with different forms of exercise and a control group. Methods: Subjects with asthma were randomly assigned to either one of three different exercise training groups (swimming, football, and basketball) or a control group. Spirometry was performed before and after and the subjects were asked to keep asthma diaries and perform daily peak flow measurements. Results: 41 children and adolescents between the ages of 9 and 16 participated in the study. After completing the training, children across all three exercise programs had significantly higher forced vital capacity (FVC) percentage values when compared to the control group. The swimming group demonstrated a significant increase in the percentage peak expiratory flow (PEF) following the exercise program when compared with the control group (78.3 ± 9.3 versus 89.0 ± 14.9, p = 0.04). All children on exercise training programs reported an improvement in their asthma symptoms via asthma diaries. Conclusion: This study suggests that a swimming training program is more beneficial in terms of peak flow measurements when compared with other exercise training programs.
Breed Differences in Dopamine Receptor D4 Gene (DRD4) in Horses

Genetic polymorphisms in genes related to neurotransmitters or hormones affect personality or behavioral traits in many animal species including humans. In domestic animals, the allele frequency of such genes has been reported to be different among breeds and it may account for breed differences in behavior. In this study, we investigated breed differences in horses in the dopamine receptor D4 gene (DRD4), which has been reported to affect horse personality. We collected samples from seven horse breeds including those native to Japan and Korea, and compared the sequence of the DRD4 exon3 region among these breeds. We found that there were two types of polymorphisms (VNTR and SNPs) in the exon3 region, and some of them seemed to be breed-specific. In addition, we found that the allele frequency of G292A, reported to be associated with horse personality, differed greatly between native Japanese horses and Thoroughbred horses. The frequency of the A allele which is associated with low curiosity and high vigilance, was much lower in native Japanese horses (Hokkaido, 0.03; Taishu, 0.08) than in Thoroughbreds (0.62). This difference may account for breed differences in personality or behavioral traits. Further studies of the function of these polymorphisms and their effect on behavior are indicated.
Experimenter gender and replicability in science

Experimenter gender influences results and may degrade replicability in many fields of scientific inquiry. There is a replication crisis spreading through the annals of scientific inquiry. Although some work has been carried out to uncover the roots of this issue, much remains unanswered. With this in mind, this paper investigates how the gender of the experimenter may affect experimental findings. Clinical trials are regularly carried out without any report of the experimenter’s gender and with dubious knowledge of its influence. Consequently, significant biases caused by the experimenter’s gender may lead researchers to conclude that therapeutics or other interventions are either overtreating or undertreating a variety of conditions. Bearing this in mind, this policy paper emphasizes the importance of reporting and controlling for experimenter gender in future research. As backdrop, it explores what we know about the role of experimenter gender in influencing laboratory results, suggests possible mechanisms, and suggests future areas of inquiry.
A novel instruction scratchpad memory optimization method based on concomitance metric

Scratchpad memory has been introduced as a replacement for cache memory as it improves the performance of certain embedded systems. Additionally, it has also been demonstrated that scratchpad memory can significantly reduce the energy consumption of the memory hierarchy of embedded systems. This is significant, as the memory hierarchy consumes a substantial proportion of the total energy of an embedded system. This paper deals with optimization of the instruction memory scratchpad based on a methodology that uses a metric which we call the concomitance. This metric is used to find basic blocks which are executed frequently and in close proximity in time. Once such blocks are found, they are copied into the scratchpad memory at appropriate times; this is achieved using a special instruction inserted into the code at appropriate places. For a set of benchmarks taken from Mediabench, our scratchpad system consumed just 59% (avg) of the energy of the cache system, and 73% (avg) of the energy of the state of the art scratchpad system, while improving the overall performance. Compared to the state of the art method, the number of instructions copied into the scratchpad memory from the main memory is reduced by 88%.
How to link call rate and p‐values for Hardy–Weinberg equilibrium as measures of genome‐wide SNP data quality

We study the link between two quality measures of SNP (single nucleotide polymorphism) data in genome‐wide association (GWA) studies, that is, per SNP call rates (CR) and p‐values for testing Hardy–Weinberg equilibrium (HWE). The aim is to improve these measures by applying methods based on realized randomized p‐values, the false discovery rate and estimates for the proportion of false hypotheses. While exact non‐randomized conditional p‐values for testing HWE cannot be recommended for estimating the proportion of false hypotheses, their realized randomized counterparts should be used. P‐values corresponding to the asymptotic unconditional chi‐square test lead to reasonable estimates only if SNPs with low minor allele frequency are excluded. We provide an algorithm to compute the probability that SNPs violate HWE given the observed CR, which yields an improved measure of data quality. The proposed methods are applied to SNP data from the KORA (Cooperative Health Research in the Region of Augsburg, Southern Germany) 500 K project, a GWA study in a population‐based sample genotyped by Affymetrix GeneChip 500 K arrays using the calling algorithm BRLMM 1.4. 0. We show that all SNPs with CR = 100 per cent are nearly in perfect HWE which militates in favor of the population to meet the conditions required for HWE at least for these SNPs. Moreover, we show that the proportion of SNPs not being in HWE increases with decreasing CR. We conclude that using a single threshold for judging HWE p‐values without taking the CR into account is problematic. Instead we recommend a stratified analysis with respect to CR. Copyright © 2010 John Wiley & Sons, Ltd.
Differentiation lineage‐specific expression of human heat shock transcription factor 2

Differentiation of multipotential hematopoietic cells into lineage‐committed precursors involves the selection and maintenance of appropriate programs of gene expression, regulated by specific transcription factors. Using human K562 erythroleukemia cells capable of differentiating along erythroid and megakaryocytic lineages, we explore the differentiation‐related role of heat shock transcription factor 2 (HSF2), which belongs to a family of transcription factors generally known to regulate heat shock gene expression. We demonstrate that enhanced HSF2 expression and the acquisition of HSF2 DNA binding activity are strictly specific for erythroid characteristics of K562 cells. Our results reveal a multistep regulatory process of HSF2 gene expression. In K562 cells undergoing hemin‐mediated erythroid differentiation, the increase in HSF2 protein levels is preceded by transcriptional induction of the HSF2 gene, accompanied by increased HSF2 mRNA stability. In contrast, during megakaryocytic differentiation induced bythe phorbol ester TPA, expression of HSF2 is rapidly down‐regulated, leading to a complete loss of the HSF2 protein. These results indicate that the determination of HSF2 expression occurs at the early stages of lineage commitment. Taken together, our data suggest that HSF2 could function as a lineage‐restricted transcription factor during differentiation of K562 cells along either the erythroid or the megakaryocytic pathway. —Pirkkala, L. , Alastalo, T. ‐P., Nykanen, P., Seppa, L. , Sistonen, L. Differentiation lineage‐specific expression of human heat shock transcription factor 2. FASEB J. 13, 1089–1098 (1999)
Fermi establishes classical novae as a distinct class of gamma-ray sources

A classical nova results from runaway thermonuclear explosions on the surface of a white dwarf that accretes matter from a low-mass main-sequence stellar companion. In 2012 and 2013, three novae were detected in γ rays and stood in contrast to the first γ-ray detected nova V407 Cygni 2010, which belongs to a rare class of symbiotic binary systems. Despite likely differences in the compositions and masses of their white dwarf progenitors, the three classical novae are similarly characterized as soft spectrum transient γ-ray sources detected over 2−3 week durations. The γ-ray detections point to unexpected high-energy particle acceleration processes linked to the mass ejection from thermonuclear explosions in an unanticipated class of Galactic γ-ray sources.
The Perception of Speech and Its Relation to Telephony

The intelligibility of the speech received over a communication system is usually expressed in terms of one or another measure such as the vowel or the consonant articulation, the average speech sound articulation, the syllable articulation, the word articulation, or the sentence intelligibility. The present paper establishes relationships among several of these measures and the articulation index. Relationships based upon statistical considerations are compared with the results of observations. Functions are developed which permit the calculation of articulation index and hence of articulation for communication systems which include a wide variety of response versus frequency characteristics and of noise conditions, as well as several special types of distortion. Although the treatment is predominantly empirical, the functions and processes are closely related to various fundamental properties of speech and hearing. Four principal series of articulation tests are cited in detail, some of which have been .
Effect of adiponectin on apoptosis: Proapoptosis or antiapoptosis?

Adiponectin is a protein hormone mainly secreted by adipose tissue that regulates energy homeostasis and glucose and lipid metabolism. Compared with other adipose‐derived hormones, adiponectin is very abundant in plasma and is proposed to be a convenient biomarker for many diseases. A large number of in vitro and in vivo studies support the beneficial effects of adiponectin on metabolic syndrome, diabetes, and atherosclerosis. However, the protective actions were challenged occasionally by the controversies in its role in inflammation and in the specific functions of its different conformations. Recently, quite a few reports suggested that the antiapoptotic activity of adiponectin might contribute to its therapeutic potential during ischemia/reperfusion injury in vivo, whereas some studies demonstrated that adiponectin induced apoptosis both in vitro and in vivo. Herein, this review attempts to summarize the present consensus and divergence and to provide possible alternative and/or complementary explanations for this apparent paradox.
About the relevance of accessibility barriers in the everyday interactions of older people with the web

This paper reports key findings of a 3-year ethnographical study of the everyday interactions of older people with the web. The data consisted of in-situ observations and conversations with 388 older people while using myriads of web and computer technologies daily. The results revealed that the accessibility barriers that had a more negative effect on the daily interactions of older people with the web were due to their difficulties in remembering steps, understanding web and computer jargon and using the mouse, despite their willingness to use it. These obstacles were much more important than those caused by their difficulties perceiving visual information, understanding icons and using the keyboard. The prioritization of barriers was explained by two key aspects in ageing with new technologies, independency and inclusiveness, and a desired condition of web (user) interfaces, consistency in terminology. These results suggest that these three aspects should be considered carefully in enhancing web accessibility for older people, as well as allowing us to grasp older people's everyday web accessibility barriers. The paper discusses possible ways of making use of these findings to make the web more accessible to older people.
Mode-dependent control of human walking and running as revealed by split-belt locomotor adaptation

ABSTRACT Here, we investigate the association of neural control between walking and running, and in particular, how these two gait modes at different velocities are controlled by the central nervous system. The subjects were fully adapted by acquiring modified motor patterns to either walk or run on a split-belt treadmill driven in split mode (asymmetry in the velocities of two belts at 1.0 and 2.0 m s−1). Subsequently, we tested how the adaptation affected walking and running at three different velocities in the tied mode (equal belt velocities). At 0.75 m s−1, we found a preference to walk, at 1.50 m s−1, there was a preference to both walk and run, and at a velocity of 2.25 m s−1 there was a preference to run. Both walking and running on the split belt resulted in the emergence of a significant aftereffect (asymmetrical movement) at all of the velocities tested when walking after adapting to walk and running after adapting to run. However, for contrasting modes (i.e. running after adapting to walk and walking after adapting to run), such aftereffects were far less evident at all velocities; thus showing only limited transfer across gait modes. The results demonstrate a clear mode dependency in the neural control of human walking and running. In addition, only for walking, was there a degree of velocity dependency. Summary: Walking and running are not simply dependent on velocity, but are controlled by the CNS as two completely distinct forms of locomotion in humans.
A flexible protection scheme for an islanded Multi-Microgrid

Multi-Microgrids (MMGs) have been proposed to connect distributed generators (DG), microgrids (MG), and medium-voltage (MV) loads with the distribution system. A flexible protection scheme that enables an islanded MMG to continue operation during fault conditions is yet to be developed. In this paper, a protection scheme for an islanded MMG that utilises MG controllers and communication links is proposed. The MMG model used includes two MGs connected to the distribution system. Each MG consists of diesel, wind, and photovoltaic (PV) microsources. The effectiveness of the proposed protection scheme is evaluated by simulation.
28.5 A 10b 1.5GS/s pipelined-SAR ADC with background second-stage common-mode regulation and offset calibration in 14nm CMOS FinFET

High-speed SAR ADCs became popular with modern CMOS technologies because of their mostly digital logic, making them highly suitable for compact and power-efficient multi-GS/s time-interleaved ADCs. As many applications cannot tolerate input swings ≥1Vppd, comparator noise limits the SNDR of SAR ADCs, making gain stages necessary for higher SNDR - either as comparator pre-amplifiers or between pipelined stages. Pre-amplifiers significantly reduce the conversion speed of the ADC, but they provide maximum SNDR because linearity of the amplifier is irrelevant. An interstage amplifier for pipelining best suits mid-resolution SAR ADCs, where the required linearity is limited. Moreover, pipelining results in higher conversion speeds and power efficiency because the gain stage is used only once per conversion [1]. This work presents a pipelined-SAR ADC architecture that exceeds the conversion speed of previous pipelined and single-stage SAR ADCs. The ADC achieves 50dB SNDR and 950MS/s at 2.26mW, and 1.5GS/s at 6.92mW on an area of 0.0016mm2.
Human Computer Interactions for Amyotrophic Lateral Sclerosis Patients

In this chapter, alternative communication and device control channels, which are helpful for Amyotrophic lateral sclerosis (ALS) patients, are introduced. In this context, human computer interactions (HCIs) will be discussed in three respects; electrical brain activities, eye movements and hemoglobin level in the blood. With technological advances, fighting or minimization side effects of the diseases is the main purpose of biomedical research. Under this motto, this chapter focuses on HCIs for individuals suffering from motor neuron diseases. ALS is a progressive neurodegenerative disease caused by the degeneration of motor neurons. ALS or other tetraplegic clinical conditions, otherwise known as the locked-in syndrome, have severe disabilities in controlling muscles and consequently have problems in moving the entire body. Some of these patients can only move their eyes. In severe conditions of the progressive motor neuron diseases, patients cannot move their eyes nor can they speak. Establishing an efficient communication channel without overt speaking and hand motions makes the patient’s life a bit easier and increases their quality of life. ALS occurs in between 4 and 8 out of every 100,000 individuals and only a small percentage of cases arise from a known genetic cause (Parker & Parker, 2007). Concerning other motor neuron diseases or speaking and muscular disabilities, there are more than 100 million potential users in need of alternative channels such as brain computer interface (BCI) for communicating with their environment or for controlling devices (Guger, 2008). Considering life span extension and increasing causes of injuries including traffic accidents and explosions, which may result in spinal cord injuries in serious cases, the need for an efficient communication or control channel has been drastically increasing. HCIs are a research field which includes interactions such as communication and device/machine control between a user and a computer. The aim of the HCI is to improve performance of the interaction, meaning a minimization of the barrier between the human and the computer. Accurate and fast interpretation of what the user wants to do as well as a correct understanding by the computer of the user's intentions or demand is the aim of this research field. Man-machine interface (MMI), brain-machine interface (BMI) and BCI can be thought of as applications of HCIs. If communication or control is established directly from the brain, it is called BCI and it is the only method of interaction for the individuals with complete
Sequential Equilibria1

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