Miracle-dz/UniFAR-FTUs huggingface dataset:
A Framework to Calculate Uncertainties for Lifetime Energy Yield Predictions of PV Systems

Today, lifetime energy yield predictions should include an assessment of the uncertainties of the predicted values as a precondition for financing large PV plants in order to properly quantify risk and return. However, the approach to perform the yield prediction with attendant uncertainty estimation is not standardized which makes it difficult to compare one investment and another. Often important sources of uncertainties are not even included in the overall uncertainty assessment. A method to calculate uncertainties and P-values for year by year and lifetime energy yield predictions of PV systems is presented. The focus is on the cumulative impact of the combination of uncertainties on delivered energy going into the project pro-forma and downside financial analysis, not on estimation of uncertainties for individual modelling steps. The proposed approach is an effort to standardize the procedure of nncertaintv calculation of nrerlicted enerov vielrls of PV systems in order to properly estimate financial investment risk.
Relationship Between Cross-Polarization Discrimination (XPD) and Spatial Correlation in Indoor Small-Cell MIMO Systems

In this letter, we provide a correlated channel model for a dual-polarization antenna in indoor small-cell multiple-input multiple-output (MIMO) systems. In an indoor environment, we confirm that the cross-polarization discrimination (XPD) in the direction of angle-of-departure can be represented as the spatial correlation of the MIMO channel. We also evaluate a dual-polarization antenna-based MIMO channel model and a spatially correlated channel model using a 3-D ray-tracing simulator. Furthermore, we provide the equivalent distance between adjacent antennas according to the XPD, providing insights into designing a dual-polarization antenna and its arrays.
Towards domain adaptation for Neural Network Language Generation in Dialogue

Extending from limited domain to a new domain is crucial for Natural Language Generation in Dialogue, especially when there are sufficient annotated data in the source domain, but there is little labeled data in the target domain. This paper studies the performance and domain adaptation of two different Neural Network Language Generators in Spoken Dialogue Systems: a gating-based Recurrent Neural Network Generator and an extension of an Attentional Encoder-Decoder Generator. We found in model fine-tuning scenario that by separating slot and value parameterizations, the attention-based generators, in comparison to the gating-based generators, show ability to not only prevent semantic repetition in generated outputs and obtain better performance across all domains, but also adapt faster to a new, unseen domain by leveraging existing data. The empirical results show that the attention-based generator can adapt to an open domain when only a limited amount of target domain data is available.
Voter Turnout and Bureaucrats across Time: A Further Examination of the Bureau Voting Model in the United States

Due to questions concerning the historical application of the economic theory of voting to the bureau voting model, this study takes a longitudinal look at the relationship between government employment and voter turnout in the United States. Probit and OLS models are used to examine data from the American National Election Study covering sixteen elections from 1982 to 2012. Contrary to previous findings, government employment is not shown to have an effect on voter turnout. These results suggest that the bureau voting model may need to be refined if it is to be used in future studies.
Trapping Prion Protein in the Endoplasmic Reticulum Impairs PrPC Maturation and Prevents PrPSc Accumulation*

The conversion of the normal cellular prion protein (PrPC) into the abnormal scrapie isoform (PrPSc) is a key feature of prion diseases. The pathogenic mechanisms and the subcellular sites of the conversion are complex and not completely understood. In particular, little is known on the role of the early compartment of the secretory pathway in the processing of PrPC and in the pathogenesis of prion diseases. In order to interfere with the intracellular traffic of endogenous PrPC we have generated two anti-prion single chain antibody fragments (scFv) directed against different epitopes, each fragment tagged either with a secretory leader or with the ER retention signal KDEL. The stable expression of these constructs in PC12 cells allowed us to study their specific effects on the synthesis, maturation, and processing of endogenous PrPC and on PrPSc formation. We found that ER-targeted anti-prion scFvs retain PrPC in the ER and inhibit its translocation to the cell surface. Retention in the ER strongly affects the maturation and glycosylation state of PrPC, with the appearance of a new aberrant endo-H sensitive glycosylated species. Interestingly, ER-trapped PrPC acquires detergent insolubility and proteinase K resistance. Furthermore, we show that ER-targeted anti-prion antibodies prevent PrPSc accumulation in nerve growth factor-differentiated PC12 cells, providing a new tool to study the molecular pathology of prion diseases.
Smoking and Body Mass Index and Survival in Pancreatic Cancer Patients

Objective The objective of this study was to provide further information on the role of personal characteristics and lifestyle factors, including obesity, diabetes, and tobacco smoking, on survival from pancreatic cancer. Methods We obtained follow-up data of pancreatic cancer patients enrolled in 2 Italian case-control studies. Information on characteristics and habits up to the time of diagnosis was collected by trained interviewers. Vital status was ascertained through population registers and record linkage with health system databases. Hazard ratios (HRs) of all-cause mortality and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. Results Follow-up information was retrieved for 648 cancer patients. Compared with subjects with body mass index of less than 25 kg/m2, the HRs were 1.14 (95% CI, 0.94–1.39) for overweight (ie, 25–29.9 kg/m2) and 1.32 (95% CI, 0.98–1.79) for obese (ie, ≥30 kg/m2) patients (trend P = 0.046). The HRs were 1.37 (95% CI, 1.14–1.65) for ever, 1.30 (95% CI, 1.03–1.65) for ex-smokers, and 1.42 (95% CI, 1.16–1.73) for current versus never smokers. Increasing amount and duration of smoking were associated with reduced survival after pancreatic cancer. No association emerged with diabetes, alcohol consumption, and diet. Conclusions Smoking and overweight before diagnosis may play a role in the prognosis of pancreatic cancer, besides its etiology.
Major histocompatibility complex control of immunity elicited by genetically engineered Eimeria tenella (Apicomplexa) antigen in chickens

The immunogenicity of a recombinant Eimeria tenella coccidial antigen was studied in 6(1). B congenic chickens derived from B2B2 and B5B5 parents segregating for haplotypes B2 and B5. Five-week-old chickens were immunized with 2.4 micrograms of recombinant protein (designated 5401) in Freund complete adjuvant and challenged with 75,000 oocysts at 28 days postimmunization (DPI) to determine the degree of elicited protective immunity. Serum samples were collected weekly for 5 weeks postimmunization for analysis by enzyme-linked immunosorbent assay, immunofluorescence assay, and Western blotting. Lesion scores following oocyst challenge were significantly reduced in B5B5 chickens compared with those in B2B2 chickens. Immunization induced a sporozoite-specific immunoglobulin G (IgG) titer in serum detected by the enzyme-linked immunosorbent assay that peaked at 28 DPI, the day of challenge, in B5B5 chickens and at 42 DPI in B2B2 chickens. After challenge, this titer declined for each genotype. Anti-sporozoite IgG detected by the immunofluorescence assay attained a peak titer at 21 DPI in B2B2 chickens and 28 DPI in B5B5 chickens. Serum from immunized B5B5 chickens reacted strongly in Western blots with several high-molecular-weight (greater than 100,000), soluble proteins prepared from sporozoites. Serum from B2B2 chickens reacted with similar proteins as well as with a 51- to 53-kilodalton protein that was not labeled by serum from B5B5 chickens. These results demonstrate further the role of host genetics on anticoccidial immunity and suggest that a peak anti-sporozoite IgG titer in B5B5 chickens on the day of challenge may signal a state of immunocompetence to that challenge.
Subtoxic N‐methyl‐D‐aspartate delayed neuronal death in ischemic brain injury through TrkB receptor‐ and calmodulin‐mediated PI‐3K/Akt pathway activation

Previous studies have shown that subtoxic NMDA moderated the neuronal survival in vitro and vivo. We performed this experiment to clarify the precise mechanism underlie subtoxic NMDA delayed neuronal death in ischemic brain injury. We found that pretreatment of NMDA (100 mg/kg) increased the number of the surviving CA1 pyramidal cells of hippocampus at 5 days of reperfusion. This dose of NMDA could also enhance Akt activation after ischemia/reperfusion (I/R). Here, we examined the possible mechanism that NMDA induced Akt activation. On the one hand, we found NMDA receptor‐mediated Akt activation was associated with increased expression of BDNF (brain‐derived neurotrophic factor) and activation of its high‐affinity receptor TrkB after I/R in the hippocampus CA1 region, which could be held down by TrkB receptor antagonist K252a. On the other hand, we found that NMDA enhanced the binding of Ca2+‐dependent calmodulin (CaM) to p85 (the regulation subunit of PI‐3K), which led to the activation of Akt. W‐13, an active CaM inhibitor, prevented the combination of CaM and p85 and subsequent Akt activation. Furthermore, NMDA receptor‐mediated Akt activation was reversed by combined treatment with LY294002, the specific blockade of PI‐3K. Taken together, our results suggested that subtoxic NMDA exerts the neuroprotective effect via activation of prosurvival PI‐3K/Akt pathway against ischemic brain injury, and BDNF‐TrkB signaling and Ca2+‐dependent CaM cascade might contribute to NMDA induced activation of PI‐3K/Akt pathway. © 2007 Wiley‐Liss, Inc.
Data science for hospitality and tourism

Purpose This paper aims to embrace the challenge of performing a state-of-the-art scientific literature analysis in data science for hospitality and tourism. This is important because relatively little contemporary analysis has been published. Design/methodology/approach Data on over 800 publications were collected from the Scopus database and analyzed by the differing types of publications, evolution of publications across time, top publishers and outlets, publications per area and per topic, top keywords used, most cited papers and most productive authors. Findings Conclusions are drawn and some suggestions are offered regarding topics that are likely to provide opportunities for future research. Originality/value This paper identifies the need for analysis on state-of-the-art academic research published to-date on the application of methods and techniques relating to data science in hospitality and tourism.
A smart netizen development for students as a leader inside Indonesias' universities using Honeycomb framework- Joe Edwards and Daniel Goleman concepts to create "Empathy Netizen Methodology" to give a positive impact in facing ASEAN economic community (AEC)

Social media is growing very fast in this globalization era, most of industry and society use this thing to get advantages, but there also negative impacts from using this social media. The open trade condition name ASEAN Economic Community already forces all parts of countries including organizations to concern about their capabilities as a bargaining power, to conquer the competition as a leader. Leaders should have capabilities to lead their selves and others as a team in an organization, because nowadays, the success story can not be achieved only by one person, but by team works. Universities are one of the factors that drive the wheel system that will develop competence people for this condition. Again, the information development will impact to the mindset, concept and the social interaction way. In this paper, Honeycomb-Joe Edwards-Daniel Goleman Concepts is used to develop a framework that can be used as guidance to make cyber society with high empathy. The Empathy Netizen Methodology can be used to combine knowledge, mindset, and heart by analyze information.
Growth Divergence and Income Inequality in OECD Countries: The Role of Trade and Financial Openness

This paper analyzes trade and financial openness effects on growth and income inequality in 35 OECD countries. Our model takes into account both short run and long run effects of factors explaining income divergence between and within the countries. We estimate, for the period 1995-2016, an error correction model in which per capita GDP and inequality are driven by changes over time of selected factors and by the deviation from a long run relationship. Stylised facts suggest that trade and financial openness reduce the growth gaps across the countries but not income inequality, and the effects of finance are stronger in high income countries. Nevertheless, low and middle income countries benefit more from international trade. Our contribution to the existing literature is threefold: i) we study the short and long run effects of trade and financial openness on income level and distribution, ii) we focus on developed countries (OECD) rather than on developing and iii) we provide a sensitivity analysis including in our baseline equation an institutional indicator, a trade agreement proxy and a dummy of global financial crisis. Estimates results indicate that trade openness significantly improved the conditions of OECD low income countries both in short and long run mostly, consistently with the catching up theory. It also decreased inequality, but only in low and middle income countries. Differently financial openness had a positive and significant impact only in the short run on middle income countries and increased income disparities within countries in the short term in low income countries and in the long term in high income countries.
Evaluation of a Romanian version of the Bath Ankylosing Spondylitis Functional Index (BASFI) in patients with spondylarthropathies.

OBJECTIVE To develop a Romanian version of the Bath Ankylosing Spondylitis Functional Index (BASFI) and to determine its metric properties in patients with spondylarthropathies (SpA). METHODS A Romanian version of BASFI was obtained after translation, back-translation and pretesting. Altogether 41 SpA patients fulfilling the ESSG criteria were included, 34 of them satisfying the modified New York criteria for ankylosing spondylitis. BASFI was completed by the patients along with assessment of clinical and disease activity variables by both the patient and physician. Scalability, internal consistency, reliability and construct validity of the Romanian BASFI were assessed. RESULTS Mean time to complete the questionnaire was 2 minutes. Scalability (0.2-9.7, 95% of the scale), internal consistency (Cronbach's alpha = 0.93), reliability (intraclass correlation coefficient = 0.82) and construct validity (correlations (absolute value(r) = 0.37-0.59) with spinal pain, nocturnal pain, patient's and physician's global assessment, fingers-to-floor distance, occiput-to-wall distance, modified Schober test, intermalleolar distance, and Dougados articular index) were all very satisfactory. CONCLUSIONS Translation and cultural differences did not alter the well-known value of BASFI. Therefore, the Romanian version of BASFI is reproducible and valid for the assessment of patients with spondylarthropathies.
Heritability analysis of IgG4 antibodies in autoimmune thyroid disease

Abstract A study of IgG4 autoantibody levels in juvenile thyroid disease patients showed evidence of heritability using the ROMP screening method. These levels increased with time despite the fact that total IgG antibody decreased with time. Evidence of heritability was demonstrated only in patients with high titers of autoantibodies to both thyroglobulin (Tg) and thyroperoxidase (TPO) unlike family members who may show high titers of one or the other and be asymptomatic at the time of sampling. Since high and low IgG4 levels give different heritability plots, these findings may represent a more severe fibrotic form of thyroiditis with a distinct genetic background. Hence a simple predictive approach is offered by this screening tool for the disease in patients and family members which may be helpful in the future to identify IgG4-related thyroiditis early in the course of disease without the requirement for biopsy.
Conservation implications for dingoes from the maternal and paternal genome: Multiple populations, dog introgression, and demography

Abstract It is increasingly common for apex predators to face a multitude of complex conservation issues. In Australia, dingoes are the mainland apex predator and play an important role in ecological functioning. Currently, however, they are threatened by hybridization with modern domestic dogs in the wild. As a consequence, we explore how increasing our understanding of the evolutionary history of dingoes can inform management and conservation decisions. Previous research on whole mitochondrial genome and nuclear data from five geographical populations showed evidence of two distinct lineages of dingo. Here, we present data from a broader survey of dingoes around Australia using both mitochondrial and Y chromosome markers and investigate the timing of demographic expansions. Biogeographic data corroborate the presence of at least two geographically subdivided genetic populations, southeastern and northwestern. Demographic modeling suggests that dingoes have undergone population expansion in the last 5,000 years. It is not clear whether this stems from expansion into vacant niches after the extinction of thylacines on the mainland or indicates the arrival date of dingoes. Male dispersal is much more common than female, evidenced by more diffuse Y haplogroup distributions. There is also evidence of likely historical male biased introgression from domestic dogs into dingoes, predominately within southeastern Australia. These findings have critical practical implications for the management and conservation of dingoes in Australia; particularly a focus must be placed upon the threatened southeastern dingo population.
Pilot Feasibility Study of a Telephone-Based Couples Intervention for Physical Intimacy and Sexual Concerns in Colorectal Cancer

No studies have tested interventions addressing the sexual concerns of colorectal cancer patients and their partners. The authors reported findings from a pilot feasibility study of a novel telephone-based intimacy enhancement protocol that addresses the intimacy and sexual concerns of couples facing colorectal cancer. On the basis of a flexible coping model, the intervention was designed to help couples make cognitive and behavioral shifts in their intimate relationships. Participants were 18 individuals (9 dyads) who completed the intervention and measures of feasibility (frequency, ease of use, helpfulness of skills, ratings of rapport), program evaluations, and measures of sexual and relationship functioning. Most participants reported that the intervention was “quite a bit” or “extremely” helpful and that they had used the skills taught within the past week. The skills most commonly practiced and perceived as most helpful tended to be behavioral (e.g., trying a new sexual activity). The authors found the largest effect sizes (≥.60) for sexual distress, sexual function (female), and sexual communication. Findings from this pilot study suggest that the intimacy enhancement protocol is feasible and holds promise for improving sexual and intimacy outcomes in colorectal cancer patients and their partners. The authors discuss the research and clinical implications.
Systematic gene expression profiling of mouse model series reveals coexpressed genes

A major aim of the Human Brain Proteome Project (HBPP) is a better understanding of the molecular etiology and progression of neurodegenerative diseases. Transgenic and loss‐of‐function mouse mutant lines (MMLs) serve as experimental models. Transcriptome and proteome regulate each other in a complex and controlled way, and their comparative analysis is an essential aspect. As a fundamental study, we have assessed transcript profiles using a microarray containing 21 000 cDNA probes in a series of disease models within the German Mouse Clinic (GMC). Seventeen distinct organs of one adult stage were systematically collected for each submitted MML. Samples for gene expression profiling are individually selected based on conspicuous phenotypes in at least one of 14 GMC phenotype screens or on previous knowledge of the mutant phenotype. By microarray experiments expression patterns of 90 organs from 46 MMLs were analysed, identifying up to 232 differentially expressed genes in 45 organs. Here we present an overview of the results of all MMLs analysed and demonstrate the efficiency of systematic genome‐wide expression profiling for the detection of molecular phenotypes in organs of a mammalian model organism. We identify the recurring regulation of particular genes and groups of coexpressed genes in apparently unrelated MMLs.
Blurred lines: work, eldercare and HRM

Abstract Increased levels of female labour market participation have impacted on the ability of families to provide care for elderly relatives in many industrialised societies. While work–family balance has received significant academic attention, less attention has focused specifically on individuals with eldercare responsibility, a cohort which accounts for a growing segment of the labour market internationally. Taking a qualitative research approach this paper uses work/family border theory to the constraints and facilitators to reconciling care and employment for employees working full-time in Ireland. The findings highlight the significant impact that eldercare provision has on employees with regard to day-to-day work commitments. We find that while general work–life balance policies exist within organisations, that the design and functionality of such policies are of limited value to elder caregivers. Furthermore, this paper highlights how the lack of formal HR policies around eldercare within organisations results in a reliance on supervisory discretion. We make some recommendations for organisational level strategies to address the needs of a growing number of caregivers.
Identification of Bacteroides forsythus in Subgingival Dental Plaque with the Aid of a Rapid PCR Method

Bacteroides forsythus has been shown to be prevalent among patients with periodontitis. Conventional microbiological methods used to identify this bacterium, however, are laborious and time-consuming and are therefore not well-suited for screening purposes. We have developed a polymerase chain-reaction (PCR) method which is rapid, specific, and simple to perform and does not require other sample pre-treatment except a brief centrifugation. This method was applied to the detection of B. forsythus in subgingival plaque of 58 periodontitis patients. When compared with the results of conventional culturing, the PCR method always confirmed the culture-positive results, while none of the PCR negative samples was shown to be culture-positive. The PCR method appeared to give more than double the number of samples positive for B. forsythus than culturing (89.7% vs. 37.9%). The analysis requires less than 4 hrs to perform, and is specific only to B. forsythus and sensitive enough to detect fewer than 5 bacteria.