Miracle-dz/UniFAR-FTUs huggingface dataset:
Design of a tunable high Q photonic band edge cavity on ferroelectric Barium Titanate

A band edge cavity on ferroelectric Barium Titanate is proposed. The cavity is designed by inserting a Photonic Crystal (PhC) within another PhC, so that the band edge of the core PhC falls within the band-gap of the outer PhC, which supports the slow light modes of the inner PC. The PhCs are selected based on their band diagram which is calculated by Plane Wave Expansion (PWE) method. The spectral purity, spatial and time confinement of the cavity are then studied using Finite Domain Time Difference (FDTD) method. The frequency spectrum of the designed cavity is calculated from the time response of the cavity. At the resonant wavelengths, the field profile and quality factors (Q) are calculated. The dispersive and absorptive nature of BaTiO3 is included in the calculation. It is found that the proposed cavity can sustain three high Q comparable modes. It has also been found that the tunability of the proposed band edge cavity is weaker compared to that of a photonic band-gap defect cavity.
Phase‐sensitive inversion recovery for detecting myocardial infarction using gadolinium‐delayed hyperenhancement †

After administration of gadolinium, infarcted myocardium exhibits delayed hyperenhancement and can be imaged using an inversion recovery (IR) sequence. The performance of such a method when using magnitude‐reconstructed images is highly sensitive to the inversion recovery time (TI) selected. Using phase‐sensitive reconstruction, it is possible to use a nominal value of TI, eliminate several breath‐holds otherwise needed to find the precise null time for normal myocardium, and achieve a consistent contrast. Phase‐sensitive detection is used to remove the background phase while preserving the sign of the desired magnetization during IR. Experimental results are presented which demonstrate the benefits of both phase‐sensitive IR image reconstruction and surface coil intensity normalization for detecting myocardial infarction (MI). The phase‐sensitive reconstruction method reduces the variation in apparent infarct size that is observed in the magnitude images as TI is changed. Phase‐sensitive detection also has the advantage of decreasing the sensitivity to changes in tissue T1 with increasing delay from contrast agent injection. Magn Reson Med 47:372–383, 2002. Published 2002 Wiley‐Liss, Inc.
Adherence to recommendations for the use of antifungal agents in a tertiary care hospital.

OBJECTIVES The aim of our study was to assess the adherence to labelling and international guidelines for antifungal prescribing. METHODS A retrospective study was performed in intensive care units in addition to the oncology and haematology department, which covered 70% of antifungal consumption at Hautepierre Hospital, Strasbourg, France. On reviewing medical charts, the antifungal prescription was examined in relation to the recommendations of indication, dosage, risk of drug-drug interactions and, where appropriate, antifungal susceptibility testing. Treatments were considered appropriate, inappropriate or debatable. RESULTS Between January and April 2007, 199 treatments were given for 179 different episodes in 133 adult patients. Treatments were prescribed for pre-emptive or targeted therapy (n = 90, with 60 for candidiasis, 26 for aspergillosis and 4 for other mould diseases), empirical therapy (n = 17) and primary (n = 81) or secondary (n = 11) prophylaxis. Fluconazole accounted for 67% of prescriptions, followed by voriconazole (19%), caspofungin (10%), posaconazole (2%), conventional or liposomal amphotericin B (2%), itraconazole (<1%) and terbinafine (<1%). Indication and dosage were found to be appropriate in 65% and 62% of cases, inappropriate in 22% and 21%, and debatable in 13% and 17%, respectively. The overall (by combining all assessment criteria) rate of inappropriate use was 40%. The overall survival rate at 12 weeks was highest in patients receiving appropriate therapy (81% versus 72% and 68% in the debatable and inappropriate therapy groups, respectively), with between-group differences not being significant (P = 0.49). CONCLUSIONS Our evaluation revealed a high proportion of inappropriate or debatable use of antifungal agents, while highlighting significant issues, such as inadequate dosage or indications.
Criteria for assessing theory in human resource development from an interpretive perspective

Utilizing Patterson's (Patterson, C.H. 1983. Theories of counseling and psychotherapy 4th edn. San Francisco, CA: Harper & Row) eight criteria for assessing theory in applied disciplines from a conventional perspective, these criteria are evaluated and where applicable reconstructed, reformulated and renamed from an interpretive perspective of theory building research and assessment. Five additional criteria are proposed and described: compellingness, saturation, prompt to action, fittingness and transferability/transportability. The task of developing such criteria from different paradigms of inquiry while ensuring paradigmatic congruence holds particular challenges, a number of which are discussed. Conclusions and preliminary implications for undertaking this task are presented and summarized.
ReSense

To utilize the full potential of modern chip multiprocessors and obtain scalable performance improvements, it is critical to mitigate resource contention created by multithreaded workloads. In this article, we describe ReSense, the first runtime system that uses application characteristics to dynamically map multithreaded applications from dynamic workloads—workloads where multithreaded applications arrive, execute, and terminate continuously in unpredictable ways. ReSense mitigates contention for the shared resources in the memory hierarchy by applying a novel thread-mapping algorithm that dynamically adjusts the mapping of threads from dynamic workloads using a precalculated sensitivity score. The sensitivity score quantifies an application's sensitivity to sharing a particular memory resource and is calculated by an efficient characterization process that involves running the multithreaded application by itself on the target platform. To measure ReSense's effectiveness, sensitivity scores were determined for 21 benchmarks from PARSEC-2.1 and NPB-OMP-3.3 for the shared resources in the memory hierarchy on four different platforms. Using three different-sized dynamic workloads composed of randomly selected two, four, and eight corunning benchmarks with randomly selected start times, ReSense was able to improve the average response time of the three workloads by up to 27.03%, 20.89%, and 29.34% and throughput by up to 19.97%, 46.56%, and 29.86%, respectively, over the native OS on real hardware. By estimating and comparing ReSense's effectiveness with the optimal thread mapping for two different workloads, we found that the maximum average difference with the experimentally determined optimal performance was 1.49% for average response time and 2.08% for throughput.
Multiscale coupling of compliant and rigid walls blood flow models

Numerical methods based on geometrical multiscale models of blood flows solve for averaged flow statistics on a network of vessels while providing more detailed information about fluid dynamics in a specific region of interest. In such an approach, a 3D model based on the Navier–Stokes equations posed in a domain with rigid walls is often used to describe blood flow dynamics in the refined region. While ignoring elasticity effects in 3D models is plausible in certain applications and saves computational time significantly, coupling such models with 1D flow models may result in non‐physiological phenomena in the computed solutions. Thus, the immediate coupling conditions based on continuity of normal stresses, flow rate, pressure, or a combination of thereof do not account for the inconsistency between elasticity effects in the 1D model and the non‐compliance of the 3D model. In this paper, we introduce and study an auxiliary absorbing 0D model, which is placed at the interface between 1D and 3D models. A virtual device mimics the effect of the 3D model compliance and hence reduces pressure wave reflection and instabilities caused by the inconsistency. The absorbing model is developed from basic mechanical principles. As a result, parameters of the 0D model can be designed based on hemodynamic data. We analyze the stability of the geometrical multiscale model and perform several numerical experiments to assess its computational efficiency. Copyright © 2016 John Wiley & Sons, Ltd.
Antigenic and structural properties of the hemagglutinin-neuraminidase glycoprotein of human parainfluenza virus type 3: sequence analysis of variants selected with monoclonal antibodies which inhibit infectivity, hemagglutination, and neuraminidase activities

The hemagglutinin-neuraminidase (HN) gene sequence was determined for 16 antigenic variants of human parainfluenza virus type 3 (PIV3). The variants were selected by using monoclonal antibodies (MAbs) to the HN protein which inhibit neuraminidase, hemagglutination, or both activities. Each variant had a single-point mutation in the HN gene, coding for a single amino acid substitution in the HN protein. Operational and topographic maps of the HN protein correlated well with the relative positions of the substitutions. There was little correlation between the cross-reactivity of a MAb with the bovine PIV3 HN and the amount of amino acid homology between the human and bovine PIV3 HN proteins in the regions of the epitopes, suggesting that many of the epitopes are conformational in nature. Computer-assisted analysis of the HN protein predicted a secondary structure composed primarily of hydrophobic beta sheets interconnected by random hydrophilic coil structures. The HN epitopes were located in predicted coil regions. Epitopes recognized by MAbs which inhibit neuraminidase activity of the virus were located in a region which appears to be structurally conserved among several paramyxovirus HN proteins and which may represent the sialic cid-binding site of the HN molecule.
Properties of the Extremal Infinite Smooth Words

Smooth words are connected to the Kolakoski sequence. We construct the maximal and the minimal in nite smooth words, with respect to the lexicographical order. The naive algorithm generating them is improved by using a reduction of the De Bruijn graph of their factors. We also study their Lyndon factorizations. Finally, we show that the minimal smooth word over the alphabet f1; 3g belongs to the orbit of the Fibonacci word.
The UL8 subunit of the herpes simplex virus helicase-primase complex is required for efficient primer utilization

The herpes simplex virus (HSV) type 1 helicase-primase is a three-protein complex, consisting of a 1:1:1 association of UL5, UL8, and UL52 gene products (J.J. Crute, T. Tsurumi, L. Zhu, S. K. Weller, P. D. Olivo, M. D. Challberg, E. S. Mocarski, and I. R. Lehman, Proc. Natl. Acad. Sci. USA 86:2186-2189, 1989). We have purified this complex, as well as a subcomplex consisting of UL5 and UL52 proteins, from insect cells infected with baculovirus recombinants expressing the appropriate gene products. In confirmation of previous reports, we find that whereas UL5 alone has greatly reduced DNA-dependent ATPase activity, the UL5/UL52 subcomplex retains the activities characteristic of the heterotrimer: DNA-dependent ATPase activity, DNA helicase activity, and the ability to prime DNA synthesis on a poly(dT) template. We also found that the primers made by the subcomplex are equal in length to those synthesized by the UL5/UL8/UL52 complex. In an effort to uncover a role for UL8 in HSV DNA replication, we have developed a model system for lagging-strand synthesis in which the primase activity of the helicase-primase complex is coupled to the activity of the HSV DNA polymerase on ICP8-coated single-stranded M13 DNA. Using this assay, we found that the UL8 subunit of the helicase-primase is critical for the efficient utilization of primers; in the absence of UL8, we detected essentially no elongation of primers despite the fact that the rate of primer synthesis on the same template is undiminished. Reconstitution of lagging-strand synthesis in the presence of UL5/UL52 was achieved by the addition of partially purified UL8. Essentially identical results were obtained when Escherichia coli DNA polymerase I was substituted for the HSV polymerase/UL42 complex. On the basis of these findings, we propose that UL8 acts to increase the efficiency of primer utilization by stabilizing the association between nascent oligoribonucleotide primers and template DNA.
Meiosis in Mice without a Synaptonemal Complex

The synaptonemal complex (SC) promotes fusion of the homologous chromosomes (synapsis) and crossover recombination events during meiosis. The SC displays an extensive structural conservation between species; however, a few organisms lack SC and execute meiotic process in a SC-independent manner. To clarify the SC function in mammals, we have generated a mutant mouse strain (Sycp1 −/− Sycp3 −/−, here called SC-null) in which all known SC proteins have been displaced from meiotic chromosomes. While transmission electron microscopy failed to identify any remnants of the SC in SC-null spermatocytes, neither formation of the cohesion axes nor attachment of the chromosomes to the nuclear membrane was perturbed. Furthermore, the meiotic chromosomes in SC-null meiocytes achieved pre-synaptic pairing, underwent early homologous recombination events and sustained a residual crossover formation. In contrast, in SC-null meiocytes synapsis and MLH1-MLH3-dependent crossovers maturation were abolished, whereas the structural integrity of chromosomes was drastically impaired. The variable consequences that SC inactivation has on the meiotic process in different organisms, together with the absence of SC in some unrelated species, imply that the SC could have originated independently in different taxonomic groups.
The gendering of global citizenship: findings from a large-scale quantitative study on global citizenship education experiences

The growing literature on the gendering of citizenship and citizenship education highlights that western notions of ‘citizenship’ have often been framed in a way that implicitly excludes women. At the same time, insofar as feminist writers have addressed citizenship, they have tended to see it in largely local and national terms. While feminist literature has laid the groundwork for understanding how schools have shaped and structured a gendered citizenry, there is a lack of large-scale quantitative data which might allow us to explore the intersection between gender and global citizenship education. Drawing on a large-scale quantitative study on development education/global citizenship education in second-level schools, the data presented here suggest that emergent notions of global citizenship are being gendered in schools. The data suggest that girls’ schools are more likely than other types of schools to emphasise a sense of responsibility for, and an analysis of, global inequalities, while differences also emerge between boys’ schools and co-educational schools.
Reforming the Law: Impact of Child Development Research

When does social science research reach the legal system? What determines whether and how it is used when it gets there? To answer these questions, REFORMING THE LAW assesses the impact of research on children's competence in decision making and also looks more generally at the effectiveness of social scientists in reaching legal decision makers. The authors give practical guidance to social scientists who wish to influence the legal system. They also provide new insights into the sociology of the law and the social sciences. Drawn from both academia and policy centers, the authors apply their backgrounds in law, psychology, and policy analysis for a rich interdisciplinary discussion of the process of legal policy making. A product of a study group sponsored by the Society for Research in Child Development, REFORMING THE LAW has special significance for child development researchers, legal policy makers, and practitioners. Readers interested in the development of child legal policy, social scientists who seek to inform the law, and anyone wishing to understand the interaction between law and social science will also find this volume an invaluable resource.
Exploring the Role of Value in the Technology Sourcing Decision

New product development is a process that involves the combination and configuration of a multitude of individual technologies. Research and experience show that all firms, even those that are very large, have resource limitations that prevent them from maintaining and developing all of the necessary technologies in-house. The question for firms concerning the management of individual technologies is a complex one. This research adds to our present knowledge of the technology sourcing decision by exploring how the value of a technology is related to whether a firm develops a technology internally or sources it through some external means. This research is set in the medical devices industry, and the conceptual model linking value to technology sourcing is based on previous literature and on exploratory interviews conducted in Finland and the United States. The model is tested with survey data gathered from American firms on 162 individual technologies. The results indicate that the relationship between value and internal sourcing is strongest when value is defined operationally (reduces costs) than when it is defined strategically (increases differentiation). Additionally, the uniqueness of a technology is antecedent to its value
Quantitative Comparison of Long-wavelength Alexa Fluor Dyes to Cy Dyes: Fluorescence of the Dyes and Their Bioconjugates

Amine-reactive N-hydroxysuccinimidyl esters of Alexa Fluor fluorescent dyes with principal absorption maxima at about 555 nm, 633 nm, 647 nm, 660 nm, 680 nm, 700 nm, and 750 nm were conjugated to antibodies and other selected proteins. These conjugates were compared with spectrally similar protein conjugates of the Cy3, Cy5, Cy5.5, Cy7, DY-630, DY-635, DY-680, and Atto 565 dyes. As N-hydroxysuccinimidyl ester dyes, the Alexa Fluor 555 dye was similar to the Cy3 dye, and the Alexa Fluor 647 dye was similar to the Cy5 dye with respect to absorption maxima, emission maxima, Stokes shifts, and extinction coefficients. However, both Alexa Fluor dyes were significantly more resistant to photobleaching than were their Cy dye counterparts. Absorption spectra of protein conjugates prepared from these dyes showed prominent blue-shifted shoulder peaks for conjugates of the Cy dyes but only minor shoulder peaks for conjugates of the Alexa Fluor dyes. The anomalous peaks, previously observed for protein conjugates of the Cy5 dye, are presumably due to the formation of dye aggregates. Absorption of light by the dye aggregates does not result in fluorescence, thereby diminishing the fluorescence of the conjugates. The Alexa Fluor 555 and the Alexa Fluor 647 dyes in protein conjugates exhibited significantly less of this self-quenching, and therefore the protein conjugates of Alexa Fluor dyes were significantly more fluorescent than those of the Cy dyes, especially at high degrees of labeling. The results from our flow cytometry, immunocytochemistry, and immunohistochemistry experiments demonstrate that protein-conjugated, long-wavelength Alexa Fluor dyes have advantages compared to the Cy dyes and other long-wavelength dyes in typical fluorescence-based cell labeling applications.
The Embedded Acquis Communautaire: Transmission Belt and Prism of New Governance

The European Union offers crucial insights into the gradual shift from a Weberian form of modern ‘government’ towards the institutionalisation of post-Weberian ‘governance’. The article argues that the emerging ‘polity of polities’ context, not only threatens the constitutional basis of democratic rule but also raises the questions of what exactly the new institutions of governance beyond the nation-state are, and what they imply for the functioning (rules of the game) and legitimacy (democratic processes) of the political order. In an effort to elaborate on these questions, the article develops two themes. First, it raises critical questions about the conceptual boundedness of ‘governance’ in the discussion of constitutional and policy studies within the field of European integration. Secondly, it advances a methodological access point for the study of the institutionalisation of governance in the Euro-polity. It suggests situating the legal concept of acquis communautaire at the boundary of legal studies and politics. The concept is then applied to a case study of citizenship policy in the EU to demonstrate how the acquis communautaire–more precisely, the ‘embedded acquis communautaire’–facilitates methodological access to the study of the institutionalisation of governance beyond the state and despite states.
The effects of Israeli use of coercive and conciliatory tactics on Palestinian's use of terrorist tactics: 2000–2006

The study investigated the effects of Israel's use of offensive, defensive and conciliatory tactics on Palestinian's use of terrorist tactics. Proportional hazard modeling assessed the effects of Israeli tactics on total terrorist activity by Palestinians, suicidal and non-suicidal acts of terror, and acts of terror attributed to Hamas, Palestinian Islamic Jihad and factions affiliated with Fatah. Palestinian acts of terror decreased following the construction of the separation fence, but increased during Operation Defensive Shield (ODS). However, the effects of various Israeli tactics differed for the different groups. Targeted assassinations increased Hamas terrorist activity, increased PIJ activity only if highly senior persons were targeted, and had no immediate effect on terrorist activity by Fatah-affiliated factions. ODS increased terrorist activity by Fatah-affiliated factions but had no effect on Hamas and PIJ. Several conciliatory measures were followed by periods of no terrorist activity at all by Hamas and Fatah-affiliated factions. The findings highlight the importance of considering the responses of different terrorist groups when evaluating effects of counterterrorist tactics.
Preprint Towards Variation-Aware Test Methods

Nanoelectronic circuits are increasingly affected by massive statistical process variations, leading to a paradigm shift in both design and test area. In circuit and system design, a broad class of methods for robustness like statistical design and self calibration has emerged and is increasingly used by the industry. The test community’s answer to the massive-variation challenge is currently adaptive test. The test stimuli are modified on the fly (during test application) based on the circuit responses observed. The collected circuit outputs undergo statistical post-processing to facilitate pass/fail classification. We will present fundamentals of adaptive and robust test techniques and their theoretical background. While adaptive test is effective, the understanding how it covers defects under different process parameter combinations is not fully established yet with respect to algorithmic foundations. For this reason, novel analytic and algorithmic approaches in the field of variation-aware testing will also be presented in the tutorial. Coverage of defects in the process parameter space is modeled and maximized by an interplay between special fault simulation and multi-constrained ATPG algorithms. These systematic approaches can complement adaptive test application schemes to form a closed-loop system that combines analytical data with measurement results for maximal test quality.