Miracle-dz/UniFAR-FTUs huggingface dataset:
Ewing Tumors That Do Not Overexpress BMI-1 Are a Distinct Molecular Subclass with Variant Biology: A Report from the Children's Oncology Group

Purpose: Ewing sarcoma family tumors (ESFT) are aggressive tumors of putative stem cell origin for which prognostic biomarkers and novel treatments are needed. In several human cancers, high expression of the polycomb protein BMI-1 is associated with poor outcome. We have assessed the potential clinical significance of BMI-1 expression level in ESFT. Experimental Design: BMI-1 expression was assessed in 130 tumors by immunostaining and associations with clinical features and outcome determined. The molecular signatures of BMI-1–low and BMI-1–high tumors were compared using microarrays and differentially activated canonical pathways identified by gene-specific enrichment analysis. Automated quantitative analysis of phosphoproteins was used to assess relative levels of pathway activation. Sensitivity to IGF1-R inhibition was determined using MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] assays. Results: BMI-1 is overexpressed by the vast majority of ESFTs. However, in 20% of cases, BMI-1 levels are low to undetectable. Significantly, although clinical presentation and outcome were similar between BMI-1–high and BMI-1–low tumors, whole genome expression array analysis showed marked differences in their respective gene expression profiles. Gene-specific enrichment analysis identified that several cancer-associated canonical biological pathways, including IGF1, mTOR, and WNT, are significantly downregulated in BMI-1–low compared with BMI-1–high tumors. Consistent with these in vivo data, the response to IGF1-R inhibition in vitro was diminished in BMI-1–low compared with BMI-1–high ESFT cells. Conclusion: ESFT that do not overexpress BMI-1 represent a novel subclass with a distinct molecular profile and altered activation of and dependence on cancer-associated biological pathways. Clin Cancer Res; 17(1); 56–66. ©2010 AACR.
Brand posts on Sina Weibo: Predicting popularity

Sina Weibo has become one of the most popular sites in China. Attracted by the huge commercial potential on Sina Weibo, many companies create their own Weibo accounts to enhance their online influence. Companies deliver information and interact with customers through placing brand posts. In this paper, some features are extracted from properties of brand posts and evaluate the roles of these features in predicting the popularity of brand posts. The reposts count of a brand post is regarded as an important indicator of online popularity because it reveals both the public attention and the spread of a post. Linear regression is used to figure out the relationship between the selected features and the reposts counts. In our experiments, it is possible to predict ranges of popularity on Sina Weibo with an overall 81% accuracy.
Introduction to personality and intelligence

PART ONE: DESCRIBING PERSONALITY What Is Personality? Trait Psychology Challenges and Alternatives to Trait Psychology PART TWO: EXPLAINING PERSONALITY Biological Approaches to Personality Psychoanalytic Approaches to Personality Cognitive Approaches to Personality PART THREE: PERSONALITY IN PRACTICE Personality Change and Development The Assessment of Personality Personality and Mental Disorder Psychobiography and Life Narratives PART FOUR: INTELLIGENCE Intelligence and Cognitive Abilities
Design of a Highly Integrated and Reliable SDR Platform for Multiple RF Applications on Spacecrafts

The utilization of Software-Defined Radios (SDR) has already become state-of-the-art for terrestrial Radio Frequency (RF) and wireless applications. The almost conservative space industry also identified the benefits of reconfigurable radio systems and uses SDRs on satellites and space vehicles. The traditional definition of a software-defined radio thereby is the digital implementation of applications in Field Programmable Gate Arrays (FPGA) or Digital Signal Processors (DSP). The analog parts (e.g. RF components) of the radio are generally tailored to the application specification and are not, or only partly, configurable. With the release of programmable and reconfigurable Radio Frequency Integrated Circuits (RFIC), a new era of SDRs was declared, which allows more flexibility and higher performance into smaller dimension. Thus, making these benefits available for applications on spacecraft has been identified as a big challenge, since those technologies are not designed for the harsh environmental conditions in space. This paper presents an approach for a highly integrated and reliable Generic Software Defined-Radio (GSDR) platform design and the results of a pre-evaluation test under radiation conditions on a prototype, to investigate certain mitigation techniques and a preconceived selection of system components. Focus of this platform is the integration into a satellite system, in order to operate multiple RF and wireless communication applications, where typically specific units for each application are used.
International Journal of Nanomedicine Dovepress Open Access to Scientific and Medical Research Open Access Full Text Article Dovepress Irradiation Stability and Cytotoxicity of Gold Nanoparticles for Radiotherapy

Gold nanoparticles are promising as a kind of novel radiosensitizer in radiotherapy. If gold nanoparticles are shown to have good irradiation stability and biocompatibility, they would play an important role in radiotherapy. In this work, we investigated irradiation effects of gold nanoparticles under 2–10 kR gamma irradiation and cytotoxicity of gold nanoparticles with human K562 cells by using Cell Titre-Glo™ luminescent cell viability assay. The results revealed that gamma irradiation had not induced any obvious instability and size variations in gold nanoparticles. We found that gold nanoparticles showed excellent radiation hardness with an absorbed dose conversation factor of 9.491 rad/R. Meanwhile, the surface plasmon resonance of gold nanoparticles was enhanced obviously after 2–10 kR gamma irradiation. Subsequently, cytotoxicity tests indicated that the extremely high concentration of gold nanoparticles could cause a sharp decrease in K562 cell viability, while the low concentration of gold nanoparticles had no obvious influence on the cell viability. Our results revealed that gold nanoparticles were stable under high-energy ray irradiation and showed concentration-dependent cytotoxicity.
Identification of machine parameters of a synchronous motor

This paper presents a method for estimating the machine parameters of a synchronous motor. The presented method is equally applicable for a wound field synchronous motor, synchronous reluctance motor, or permanent magnet (PM) synchronous motor, both the interior and surface-mount types. The method works particularly well for machines having a significant amount of space harmonics, such as synchronous reluctance and interior PM (IPM) machines, where the harmonics are predominantly the slot harmonics. It is also well suited for surface PM machines operating under saturation, where the harmonics are saturation-induced. The presence of these harmonics makes the parameter identification difficult. Most of the methods presented so far in the literature have failed to properly identify machine parameters in the presence of space harmonics. In this paper, the machine parameters, identified by using a proposed algorithm, are compared with the finite element and the experimental results to demonstrate the effectiveness of the presented method. Both interior PM and surface PM machines are considered.
Assessing the Learning Needs of Adults with Acquired Physical Disability in Vocational Rehabilitation

i Chapter I : Thesis Proposal 1 Chapter 2: Literature Review 13 Chapter 3: Methodology and Data Analysis 31 Chapter 4: Findings 43 Chapter 5: Interpretations/Implications 53 Chapter 6: Conclusions and Plans for D issem ination 58 References 62 Appendixes 68 Appendix A; Screened Assessments Grouped by Type Appendix B: Alphabetic Listing of Screened Assessments Appendix C: Assessment Screening Worksheet Appendix D: List of Test Publishers
Combining Tiled and Textual Views of Code

Jigsaw puzzle programming environments manipulate programs primarily by drag-and-drop. Generally these environments are based on their own special-purpose languages, meaning students must move on to another language as their programs grow. Tiled Grace is a tile-based editor for Grace, an educational programming language with a conventional textual syntax. Using Tiled Grace, programmers can move seamlessly between visualising their programs as tiles or source code, editing their programs via tiles or text, and continue on to traditional textual environments, all within the same programming language. We conducted a user experiment with Tiled Grace, and present the results of that experiment showing that users find dual views helpful.
Perceptual learning of binocular interactions

PERCEPTUAL LEARNING OF BINOCULAR INTERACTIONS Jingping Xu June 7,2011 This dissertation focuses on the mechanisms and implications of perceptual learning of binocular interactions. Perceptual learning is an important means of adapting to the changing environment, demonstrating the possibility of neural plasticity in adults and providing a powerful approach to investigate dynamic processes in the mature perceptual system. Most studies on perceptual learning have focused on learning mechanisms that target excitatory circuits. However, we recognize that the inhibitory circuits also playa critical role in cortical plasticity, as shown by growing evidence from neurophysiological studies, and that the inhibitory connection is more dynamic than the excitatory connection in adult visual cortex. Thus, our goal is to design a psychophysical method that exploits the contribution of the inhibitory circuits to perceptual learning. This in turn helps us to implement more efficient learning paradigms for visual training. Our study capitalizes on properties of the binocular visual system, a good system for exploring both excitatory and inhibitory mechanisms. We first measured local Sensory Eye Dominance (SED) and showed that excessive SED can impede stereopsis ability. To reduce SED, a typical perceptual training paradigm (Push-only protocol) would only
An Examination of the Association Between Student-Teacher Interactions and Academic Self- Concept Among African American Male High School Students

OF THESIS AN EXAMINATION OF THE ASSOCIATION BETWEEN STUDENT-TEACHER INTERACTIONS AND ACADEMIC SELF-CONCEPT AMONG AFRICAN AMERICAN MALE HIGH SCHOOL STUDENTS Students generally spend more than ten years interacting with teachers in a classroom and thus, such interactions can have a positive or negative impact on students’ academic self-concept and educational goals (Rosenthal, Folse, Allerman, Boudreaux, Soper, & Von Bergen, 2000). The purpose of this study is to determine whether there is a significant relationship between student-teacher interactions and academic self-concept. Participants in the study include African American male high school students in an urban school district. The independent variable is the student-teacher interactions, as measured by the StudentProfessor Interaction Scale (Cokley et al., 2004). The dependent variable is the students’ academic-self-concept, which is measured by the Academic SelfConcept Scale (Reynolds, Ramirez, Magrina, & Allen, 1980). The data was analyzed by using Pearson’s correlation and hierarchical multiple regression to determine if there was a statistically significant relationship between the two variables. Findings, study limitations, and future research directions are also discussed.
A Case Base Representation Technique to Support Case Based Reasoning Content Areas: Case Based Reasoning

A representation technique whereby Case Bases (CBs) used in Case Based Reasoning (CBR) applications can be encoded is described. The representation considers the CB in terms of a multi-dimensional space where each dimension represents a particular attribute, and the values for that dimension an enumeration for that attribute. The advantages ooered are rstly that of compression | the CB is reduced to a set of integers. Secondly, unlike other CB compression techniques, the representation supports interaction without necessitating \de-compression"; further the numeric nature of the representation ensures that this interaction is computationally eeective. Thirdly, and signiicantly in the context of CBR, the representation supports mechanisms whereby CBR queries can be relaxed/expanded to support ideas concerning \similarity" retrieval. Fourthly, within certain machine dependent limitations, the technique operates regardless of the number of \dimensions" (attributes) under consideration. Finally there is no corresponding increase in the level of complexity as the number of \dimensions" increases.
Methods for measuring audience reactions

This paper describes recent developments in our investigations into psychological reactions of audience members as they watch live performance, specifically contemporary dance. The first method, developed by Glass [5,6], is a new psychometric instrument ‐ the Audience Response Tool (ART) ‐ that records emotional and cognitive responses in the form of qualitative open-ended descriptions and quantitative ratings to live performance. The second method ‐ the portable Audience Response Facility (pARF) ‐ is a programmable, hand-held PC that samples one- or two-dimensional data continuously as a performance unfolds. A third method records eye movements of novice and expert observers as they watch a pre-recorded performance. The ART was developed in the context of an experimental design that investigated the effect of pre-performance information sessions (generic, specific, no information-control group) on cognitive and emotional responses to two new Australian dance works, Anna Smith's Red Rain and Sue Healey's Fine Line Terrain. The pARF has been used to record continuous responses from 19 audience members in the Playhouse Theatre in Canberra as they watched the Quantum Leap Youth Choreographic Ensemble perform Albert David’s Silent Heartbeat. Judged emotional expression in the 30 minute work was captured in two orthogonal dimensions, valence and arousal [13]. The pARF revealed an increase in arousal as the work progressed, explicable in terms of music and movement intensity and tempo. The eye movement experiment investigated effects of observer expertise on fixation duration and saccadic amplitude while four dance experts and four novices watched a five-minute dance film, Sue Healey's 13 and 32. Expert observers relative to novices recorded shorter fixations and larger saccades. This effect has been interpreted in light of organizational strategies and expectancies acquired by experts through experience with a particular art form. The qualitative and quantitative methods have wide application across the performing arts, film, and digital media.
LaasNetExp: a generic polymorphic platform for network emulation and experiments

Network experiments are essential for assessing and validating new networking technologies, architectures and protocols. These assessments have long been performed using network simulators. But it clearly appeared that the results got in simulations cannot be reproduced in real environment. Emulators can hardly integrate accurate models of all networking components, end host operating systems and applications what leads to unrealistic simulations very often. Therefore, some work has been issued for developing real experiment platform and network emulators. This paper addresses the motivations that raised the design and development of such an experimental platform at LAAS - laasnetexp - and describes its constituting features and components. It is in particular detailed how experimental conditions can be fully controlled for reproducible and easy to analyze experiments. Last, this paper describes how realistic conditions can be set-up in experiments by using the results of actual Internet and Internet traffic characterization, analysis and modeling. Such information helps to realistically configure emulators as well as define realistic traffic generators. The realism of such experiments is illustrated as a demonstration of the interest of laasnetexp for networking research.
Affect Decoding Measures and Human-Computer Interaction

Affect measurement has been identified as a critical issue for Human-Computer Interaction (HCI) [4]. There is an established body of work in the communication science and psychology literature considering an individual’s ability to decode affect. However, this area has not yet been applied to HCI. Decoding affect is defined as “the ability to sense, perceive accurately, and respond appropriately to one’s personal, interpersonal, and social environment” [2]. Objective measurement of affect decoding is relevant for a variety of HCI applications, such as designing and selecting distance collaboration tools, analysis of behavioral video, and explicitly describing observed nonverbal behavior during dyad and group interaction studies. We are used to adapting interfaces for users with disabilities [6]; it is equally important that systems that support cooperative work should adapt to their users' difficulties with decoding affect. It is therefore necessary to be able to measure an individual’s affective decoding abilities.
Low-dimensional superpixel descriptor for visual correspondence estimation in video

Estimating local visual correspondence between video frames is an important and essential challenge in many visual applications. Keypoint based sparse matching is a common way to address the problem of local visual correspondence estimation. This paper proposes a local visual correspondence estimation method based on extracting discriminative features from superpixels. In the proposed approach, superpixels are generated by over segmentation at first. Then the superpixels are described by orientated center-boundary distance (OCB-D) and gray-level co-occurrence matrix (GLCM) which extract shape feature and texture feature, respectively. Experimental results on the widely used Middlebury dataset prove that the proposed superpixel descriptor achieves much higher accuracy than the compact ORB descriptor when same dimensions of features are used. In addition, benefited from its low-dimension character, the proposed descriptor is memory-efficient and hardware friendly.
Physiologically Based Pharmacokinetic Modeling Using Microsoft Excel and Visual Basic for Applications

Abstract Physiologically based pharmacokinetic (PBPK) models are mathematical descriptions depicting the relationship between external exposure and internal dose. These models have found great utility for interspecies extrapolation. However, specialized computer software packages, which are not widely distributed, have typically been used for model development and utilization. A few physiological models have been reported using more widely available software packages (e.g., Microsoft Excel), but these tend to include less complex processes and dose metrics. To ascertain the capability of Microsoft Excel and Visual Basis for Applications (VBA) for PBPK modeling, models for styrene, vinyl chloride, and methylene chloride were coded in Advanced Continuous Simulation Language (ACSL), Excel, and VBA, and simulation results were compared. For styrene, differences between ACSL and Excel or VBA compartment concentrations and rates of change were less than ±7.5E−10 using the same numerical integration technique and time step. Differences using VBA fixed step or ACSL Gear's methods were generally <1.00E−03, although larger differences involving very small values were noted after exposure transitions. For vinyl chloride and methylene chloride, Excel and VBA PBPK model dose metrics differed by no more than −0.013% or −0.23%, respectively, from ACSL results. These differences are likely attributable to different step sizes rather than different numerical integration techniques. These results indicate that Microsoft Excel and VBA can be useful tools for utilizing PBPK models, and given the availability of these software programs, it is hoped that this effort will help facilitate the use and investigation of PBPK modeling.
Cell design and continuous improvement

This paper describes methods for the practical implementation of the following three stages of cell design: Determining cell configurations, identifying a layout and carrying out capability analysis. Although emphasis is placed on how these stages were implemented within a cell design software package called Cellect, in order to ensure that the methods are suitable for use within small manufacturing firms, an attempt is also made to describe how cell design might be performed using office desktop software. In this respect, it has been shown that for the design of small cellular systems, a non-proprietary system can be used to implement the algorithms outlined herein, but for more advanced analysis, particularly that involving integration with external elements such as discrete event simulation, a requirement exists for a dedicated database driven system such as Cellect.
Cross-linguistic annotation of modality: a data-driven hierarchical model

We present an annotation model of modality which is (i) cross-linguistic, relying on a wide, strongly typologically motivated approach, and (ii) hierarchical and layered, accounting for both factuality and speaker’s attitude, while modelling these two aspects through separate annotation schemes. Modality is defined through cross-linguistic categories, but the classification of actual linguistic expressions is language-specific. This makes our annotation model a powerful tool for investigating linguistic diversity in the field of modality on the basis of real language data, being thus also useful from the perspective of machine translation systems.
Affective Trust as a Predictor of Successful Collaboration in Distributed Software Projects

Building trust among remote developers is challenging because trust typically grows through close face-to-face interaction. In this paper, we present the preparatory design of an empirical study aimed to assess whether affective trust, established through social communication between developers, is a predictor of successful collaboration in distributed projects. Specifically, we intend to measure affective trust through sentiment analysis of pull-request comments.
Spontaneous Thrombosis in Giant Aneurysm of the Anterior Communicating Artery Complex in Pediatric Age: Five-Year Follow-Up

Intracranial aneurysms are rare in the pediatric population, especially in infancy, representing less than 1% of all aneurysms. In this age group, they are more frequent at the carotid bifurcation and in the posterior circulation, with a greater number of giant aneurysms and spontaneous aneurysm thrombosis when compared with the adults. They are life-threatening, and, therefore, early investigation, characterization of the lesion, and treatment are essential. The appropriate management depends on the child's condition, aneurysm characteristics, and the experience of a multidisciplinary team. Noninvasive and radiation-free imagiological studies play an important role in the diagnosis and follow-up of these young patients. We present the case of a 3-month-old boy with an intracranial hemorrhage secondary to the rupture of a giant aneurysm of the anterior communicating artery complex, with spontaneous thrombosis, which is a rare situation due to its location. A conservative approach was assumed and noninvasive evolutive imagiological studies revealed a reduction in the thrombosed aneurysm size and no signs of recanalization. The child recovered to his baseline neurological condition and has had no rehemorrhage until 5 years of follow-up.