Miracle-dz/UniFAR-FTUs huggingface dataset:
Regeneration of teeth using stem cell-based tissue engineering

Tooth autotransplantation, allotransplantation and dental implants have existed for many years, but have never been totally satisfactory. Thus, the development of new methods of tooth replacement has become desirable, and with the increasing knowledge of stem cell biology becomes a realistic possibility. Stem cell-based tissue engineering involving the recapitulation of the embryonic environment demonstrates that dental, non-dental, embryonic and adult stem cells can contribute to teeth formation in the appropriate setting. Evidence that stem cell populations may be present in human teeth provides the opportunity to consider biological tooth replacement ‘new for old’.
Treatment resistance of depression after head injury: a preliminary study of amitriptyline response

Thirteen patients with depression following minor head injury were matched with 13 functional depressives. Both groups were indistinguishable psychopathologically. Five of the functional group had a family history of affective disorder and none of the head‐injury group had such a history. Both groups were treated with amitriptyline, beginning with 100 mg daily, increasing to a maximum of 250 mg/d. There were significant differences in response between the 2 groups, with only 4 of the head‐injury patients improving. Our preliminary results suggest that this condition is relatively resistant to tricyclic therapy.
FOSB INDUCTION IN NAc POSTPARTUM 1 ∆ FosB Induction in D 1 Versus D 2 Dopamine Neurons in the Nucleus Accumbens Following a Hormone-Simulated Pregnancy : An Exploratory Study

3 Postpartum Depression and Anxiety Disorders. 4 Temporal, Behavioral, and Neurological Distinctiveness of PMDs. 7 The Biology of Postpartum. 11 A Unique Neurobiological Approach for Studying PMD. 17 Summary of the Rationale for the Present Study. 30 The Present Study. 31 Methods. 33 Transgenic Mice. 33 Procedure. 34 Results. 39 Behavioral Results. 39 Neurological Results. 41 Discussion.42 Sample Limitations. 43 No Change in Anxiety Behaviors Between Hormone Conditions. 43 ∆FosB Expression in Dopamine MSNs within the NAc Core and Shell. 44 Interpreting the Behavioral and Neurological Results Together. 54 Future Directions. 56 Accounting for Limitations in the Present Study. 56 Additional Future Research Considerations. 57 Concluding Remarks. 58 References. 59 Tables and Figures. 77 ∆FOSB INDUCTION IN NAc POSTPARTUM 3 Abstract Postpartum mood disorders (PMD) are a worldwide health concern, yet the neurobiological etiology is still widely unknown. In the present study we replicated the hormone-simulated pregnancy method developed by Liisa Galea in a novel transgenic mouse model. This approach allowed us to measure long-term genomic changes in dopaminergic plasticity in medium spiny neurons (MSNs) within the nucleus accumbens (NAc) through the transcription factor ∆FosB. We used 16 ovariectomized female transgenic mice that had fluorescent reporter moleculesPostpartum mood disorders (PMD) are a worldwide health concern, yet the neurobiological etiology is still widely unknown. In the present study we replicated the hormone-simulated pregnancy method developed by Liisa Galea in a novel transgenic mouse model. This approach allowed us to measure long-term genomic changes in dopaminergic plasticity in medium spiny neurons (MSNs) within the nucleus accumbens (NAc) through the transcription factor ∆FosB. We used 16 ovariectomized female transgenic mice that had fluorescent reporter molecules coupled to either D1 or D2 receptor-containing neurons; this allowed us to differentially visualize the activity of ∆FosB in each of the neuronal subtypes following a hormone-simulated pregnancy. We found a significant increase in the expression of ∆FosB in D2-MSNs in the NAc core of hormone-withdrawn animals relative to hormone-sustained animals. These neurobiological changes did not correspond with measures of anxiety in either an Elevated Plus Maze or Open Field Test. Furthermore, we found no significant changes in ∆FosB expression in D2-MSNs in the NAc shell nor in D1-MSNs in the NAc core and shell. By further understanding the influence that hormonal changes throughout pregnancy have on neurological systems, we can identify the systems that may be involved in pathological cases to develop better and more direct treatment and diagnosis options for PMD.
Antiproliferative effect of apigenin : A flavonoid in sarcoma 180 cell line

Apigenin is a common dietary flavonoid that has been used as a traditional medicine for centuries for their promising pharmacological properties as antioxidant, antibacterial, antiviral, anti-inflammatory etc. Currently, investigation and recognition of apigenin as a cancer chemopreventive agent has increased. Hence the present study was aimed to investigate the ability of apigenin to inhibit cell proliferation in sarcoma 180 cell line. Effect on cell viability, changes in the total cellular glutathione, lipid peroxides and sialic acid levels were observed to study the antiproliferative effect of apigenin at three different dose levels with plumbagin as a positive control and DMSO as a negative control. In this study, the flavonoid apigenin significantly inhibited the cellular proliferation in a dose dependent manner. Effective inhibition of cell viability, decrease in glutathione, sialic acid levels and increase in lipid peroxides supported the antiproliferative effect of apigenin and proved that, the apigenin could be used as a natural cancer chemopreventive agent to control cancer cell proliferation.
HST STIS Observations of the Central Radio/X-Ray Source in the Compact Starburst Galaxy Henize 2-10

Abstract Based on radio and X-ray observations, it has been suggested that a black hole of mass ∼106 Mʘ resides in the dwarf starburst galaxy Henize 2-10. This unusual finding has important implications for the formation of massive black holes in the early universe since Henize 2-10 can be viewed as a low redshift analog to the first high-z galaxies. We present long-slit HST STIS spectra that include the central radio/X-ray source. While recent VLT-MUSE spectroscopic observations with 0″. 7 seeing show no change in ionization near the central source, our higher spatial resolution STIS observations identify a distinct compact region at the location of the radio/X-ray source. Initial analysis reveals broader (FWHM ∼ 380 km s-1) blue-shifted lines of low ionization. Our analysis focuses on testing two scenarios: a LINER-like AGN and a young (few decades) SNR.
SiGe HBT and BiCMOS process integration optimization within the DOTSEVEN project

This paper describes the technology development activities within the European funding project DOTSEVEN done by Infineon and IHP. After half of the project duration Infineon has developed a 130 nm SiGe BiCMOS technology with fT of 250 GHz and fmax of 370 GHz. State-of-the-art MMIC performance is demonstrated by a 77 GHz automotive radar transmitter. The suitability of IHṔs advanced SiGe HBT module with epitaxial base link for future industrial BiCMOS platforms is demonstrated by integrating it in Infineon's 130 nm process resulting in an fmax of 500 GHz, 1.8 ps gate delay and a record 161 GHz static frequency divider. IHP has achieved an fmax of 570 GHz for the first time using an HBT concept with non-selective epitaxial base deposition and an elevated extrinsic base.
Sending a Signal: The Effect of Raising Non-attendance Fees in Swedish Health Care

In this paper, we study the effect of raising the fee for non-attendance on non-attendance rates in health care from a Swedish perspective. We do this by using a difference in difference design and exploiting a natural experiment in Sweden, where one county increased non-attendance fee to the double and the other county had a constant fee. Data on individual level allows us to investigate a general effect as well as heterogeneity in treatment depending on age and tendency to miss appointments in the past. The theoretical framework departs in neoclassical theory and the deterrence hypothesis, which predict that patients will decrease their rate of non-attendance. Meanwhile, behavioral research shows that an external incentive can crowd out intrinsic motivation. The theoretical predictions of the effect of a fee are therefore ambiguous and previous research on the field is scarce. Our study can contribute with generalizable evidence from both primary and secondary care in Sweden. The results are a decrease in non-attendance rate by 39% when doubling the non-attendance fee. Skane County implemented the reform and using back of the envelope calculations indicate cost reductions estimated to at least 69.2 million SEK annually. We draw the conclusion that monetary sanctions have a large effect on non-attendance rates and signaling, through media and in the health care organization, might have enhanced the effect. (Less)
Is the disabled elderly ’ s demand for formal homecare sensitive to the out-of-pocket cost ? A multi-level analysis on French data

This article focuses on the price-elasticity of demand for formal home-care received by disabled elderly. In France a public financing system of long-term care for disabled elderly aged 60 and over called APA (Allocation Personnalisée d’Autonomie) has been set up in 2001. This policy is based on a partial subsidization of demand for formal home-care so that an out-of-pocket cost remains. It rests on three variables : the department policy and the provider chosen by the recipient and the income level of the recipient. The induced heterogeneity of the out-of-pocket cost allows price-elasticity estimations but compels me to employ two databases. I use the HSM survey an individual database on disability and health that is representative of the French and the Territoire survey which provides information in each department on the APA policy parameters. The combination of these two databases enables me to approximate the out-of-pocket cost for each individual that is the one-hour formal home-care price. I estimate a multi-level model with random effects and find that the price-elasticity of demand for formal home-care has a value of -0.15 at my average point.
0 Investigating Characteristics of Internet Paths

Interactive andmultimedia applications depend on the stability of end-to-end paths for predictable performance and good quality of service. On the other hand, network providers depend on multiple paths to ensure fault tolerance and use load balancing between these paths to enhance the overall network throughput. In this study, we analyze path dynamics for both end-to-end paths and path segments within service providers’ networks using two months of measurement data from the RIPE Atlas platform, which collects path traces between a fixed set of source and destination pairs every 15 minutes. We observe that 78% of the end-to-end routes have at least two alternative Autonomous System (AS) paths with some end-to-end routes going through hundreds of different AS paths during the two months of analysis. While AS level paths are often prevalent for a day, there are considerable changes in the routing of the trace packets over the ASes for a longer duration of a month or longer. Analyzing end-to-end paths for routing anomalies, we observe that 4.4% of the path traces (involving 18% of the ASes) contain routing loops indicating mis-configuration of routers. Some of the ASes had over 100 routers involved in loops in path traces through their networks. We observe a much higher rate of anomalies in the AS level, with 45% of path traces containing an AS loop. Additionally, we discovered that few of the ASes bounce-back packets where some traces through their network traverse routers in both forward and backward directions. Determining path segments belonging to each AS, we further explore ingress to egress paths of ASes in addition to the source to destination paths within the AS. Analyzing trace segments between ingresses and egresses of an AS, we realized more than half of the ASes have the same router level path between any ingress-egress pair for the two months, but others implement load balancing. These results are different from earlier studies that indicated a high level of path dynamism. Our results indicate that the end-to-end path dynamism is due to the BGP level rather than the router level within ASes.
Contrast based circular approximation for accurate and robust optic disc segmentation in retinal images

A new method for automatic optic disc localization and segmentation is presented. The localization procedure combines vascular and brightness information to provide the best estimate of the optic disc center which is the starting point for the segmentation algorithm. A detection rate of 99.58% and 100% was achieved for the Messidor and ONHSD databases, respectively. A simple circular approximation to the optic disc boundary is proposed based on the maximum average contrast between the inner and outer ring of a circle centered on the estimated location. An average overlap coefficient of 0.890 and 0.865 was achieved for the same datasets, outperforming other state of the art methods. The results obtained confirm the advantages of using a simple circular model under non-ideal conditions as opposed to more complex deformable models.
Retina Quantitative Fundus Autofluorescence and Optical Coherence Tomography in ABCA 4 Carriers

Citation: Duncker T, Stein GE, Lee W, et al. Quantitative fundus autofluorescence and optical coherence tomography in ABCA4 carriers. Invest Ophthalmol Vis Sci. 2015;56:7274– 7285. DOI:10.1167/iovs.15-17371 PURPOSE. To assess whether carriers of ABCA4 mutations have increased RPE lipofuscin levels based on quantitative fundus autofluorescence (qAF) and whether spectral-domain optical coherence tomography (SD-OCT) reveals structural abnormalities in this cohort.
Zero interest rate policy and asymmetric price adjustment in Japan: an empirical analysis of a nonlinear DSGE model

We incorporate zero lower bound (ZLB) in monetary policy rule and asymmetric adjustment costs (AAC) in Rotemberg price setting mechanism and solve nonlinear New Keynesian DSGE models using projection method. And we estimate the latest Japanese economy between 1981:Q3 and 2015:Q1 from the viewpoint of Bayesian approach with particle filter. Marginal likelihood shows that both ZLB and AAC overwhelmingly contribute to explain fluctuations of his output growth, inflation and nominal interest rate. This result indicates that the adjustment costs in deflation are about 24-32% higher than those in inflation. The wide curved policy functions make the effects of monetary policy shock much more uncertain expressing as spread credible bands of the impulse responses. We also report models with only the ZLB constraint might mislead the effect of monetary policy to output and inflation over-estimated in the case of Japan.
A MicroScale Approach to Ethnic Minority Concentration in the Residential Environment and Voting for the Radical Right in

Existing empirical research on the link between ethnic minority concentration in residential environments and voting for the radical right is inconclusive, mainly due to major differences between studies in the spatial scale at which minority concentration is measured. We examined whether the presence of non-western ethnic minorities in the residential environment, measured at four spatial scales, is related to individuals’ intention to vote for the Dutch Party for Freedom (Dutch acronym PVV). We combined individual level survey data and register data, and we used multi-level structural equation models to examine possible mediation by anti-immigrant attitudes and political dissatisfaction. The models show different effects at different scales. At the micro scale (100 by 100 meter grids) we find a curvilinear effect: individuals with 30–50 per cent non-western minorities in their direct living environment are most likely to report to vote for the PVV. At higher spatial scales (up to municipal level) we find that the higher the proportion of non-western minorities, the more likely individuals are to report to vote for the PVV. These effects can however not be explained by anti-immigrant attitudes or political dissatisfaction. We even find that at the micro scale the presence of non-western minorities is related to less anti-immigrant attitudes.
An open source chimera checker for the fungal ITS region

The internal transcribed spacer (ITS) region of the nuclear ribosomal repeat unit holds a central position in the pursuit of the taxonomic affiliation of fungi recovered through environmental sampling. Newly generated fungal ITS sequences are typically compared against the International Nucleotide Sequence Databases for a species or genus name using the sequence similarity software suite blast. Such searches are not without complications however, and one of them is the presence of chimeric entries among the query or reference sequences. Chimeras are artificial sequences, generated unintentionally during the polymerase chain reaction step, that feature sequence data from two (or possibly more) distinct species. Available software solutions for chimera control do not readily target the fungal ITS region, but the present study introduces a blast‐based open source software package (available at http://www.emerencia.org/chimerachecker.html) to examine newly generated fungal ITS sequences for the presence of potentially chimeric elements in batch mode. We used the software package on a random set of 12 300 environmental fungal ITS sequences in the public sequence databases and found 1.5% of the entries to be chimeric at the ordinal level after manual verification of the results. The proportion of chimeras in the sequence databases can be hypothesized to increase as emerging sequencing technologies drawing from pooled DNA samples are becoming important tools in molecular ecology research.
SeLance: Secure Load Balancing of Virtual Machines in Cloud

The rapid development of cloud computing expands the scale of modern cloud data centers, resulting in growing challenges of energy consumption. Load balancing of virtual machines(VMs), for the purposes of improving the utilization of physical resources and reducing energy consumption, has become a research focus in recent years. However, the existing researches mostly focus on how to maximize resource utilization and reduce energy consumption. Security issues in the context of load balancing of VMs were rarely addressed. In this paper, we research the key procedures of load balancing, VM selection and VM placement, we find that the existing schemes introduced several security problems. In consideration of some conclusions of recent researches and inevitable live migrations during load balancing, common tenants have sufficient reasons to worry about their VMs' security when they are migrated to strange hosts and/or co-reside with the VMs owned by strange tenants. In short, VMs' mobility introduced by load balance expands the attack surface. In this work, we classify and analyze related security threats and create an information leakage model for load balancing. We present a new security policy, SeLance, to secure the load balancing via avoiding above threats as far as possible. We develop exact implementations in CloudSim and OpenStack. We show that SeLance can effectively alleviate the threats introduced by load balancing, the security score can improve 46.90%-81.15%, while keeping the load balancer's original function to a great extent (± 2.5%).
PREPROCESSING ON FACEBOOK DATA FOR SENTIMENT ANALYSIS

In the growing digital world, people use social media to communicate each other and to express their mindset. Facebook known as the most popular social media among the others. People express their life events, day to day life, and knowledge that they have, their feelings, past, present, future and so on. Our aim is to suggest a suitable career path based on what they are sharing in the public facebook profiles. The main objective of this paper is to retrieve and pre-process the facebook data from a unique facebook profile. 200 facebook profiles were used for this survey. Most of the researches done preprocessing using the text that the facebook users shared. But in this paper especially we use spell correction and emoticon analysis. In most of the research papers uses some tools to pre-process the facebook or social media data. But I am translating and pre-processing from more than 70 languages with maximum possible accuracy. The final outcome of facebook data pre-processing will help for the better sentiment analysis.
ZC3H12A Expression in Different Stages of Colorectal Cancer

Identification of CRC patients with early-stage disease provides the opportunity for curative local resection. However, robust markers for stage I tumor prediction are yet to be developed. We analyzed RNA-sequencing data of 221 CRC samples using the TCGA dataset to identify novel biomarkers for stage I CRC. We next validated the TCGA finding in an independent GEO cohort of 290 CRC patients and in a third cohort of 110 CRC tumors and matched normal samples. We further performed correlative analysis of ZC3H12A gene expression with clinicopathologic features and disease-free survival. Expression correlation of ZC3H12A with the chemokine ligands was evaluated via Student’s t-test. In the TCGA cohort, stage I CRC patients had significantly higher ZC3H12A mRNA expression as compared with the other three stages combined and with the other individual stages in a pairwise manner (P<0.001 for all comparisons). The significant association of ZC3H12A gene expression with stages was further validated in the GEO cohort and in the additional third cohort. In support of these findings, we further found that patients with lower ZC3H12A expression had more aggressive tumor features and shorter disease-free survival. Biologically, ZC3H12A expression was significantly correlated with expression of three chemokine ligands (CXCL1, CXCL2 and CXCL3), suggesting that immune response dysregulation likely contributes to CRC development. Our results demonstrate ZC3H12A’s potential role in identification of CRC patients with early-stage disease.
A Low-Profile Dual-Band Dual-Mode and Dual-Polarized Antenna Based on AMC

A low-profile dual-band dual-mode and dual-polarized (DBDMDP) antenna based on artificial magnetic conductor (AMC) is presented in this letter. One reference antenna made of a pair of double-printed crossed dipoles employing vacant quarter-rings is originally realized with dual-band dual-polarized property but strong back radiation. Then, one square-shaped AMC layer is used instead of the metal ground with improved performance. For the lower mode (at 1.38 GHz), the AMC reflection phase of 90° is employed to change the electromagnetic field distribution and achieve monopole-like omnidirectional linear polarization (LP) radiation. Meanwhile for the higher mode (at 1.57 GHz), the AMC with reflection phase of 0° is regarded as a reflector to realize patch-like unidirectional circular polarization (CP) radiation. Thus, probe-single-feed DBDMDP antenna is realized with low-profile property of 0. 03λ0, as well as pattern and polarization diversity. One prototype is fabricated to verify the theory analysis, and the measured results reveal that the maximum gain is higher than 2 dBi and 7 dBic for the LP omnidirectional and CP unidirectional modes, respectively. With the advantages of low profile and multifunction, this method offers a good candidate for global position systems applications in the future.