Miracle-dz/UniFAR-FTUs huggingface dataset:
27.8 A 4600μm2 1.5°C (3σ) 0.9kS/s thermal-diffusivity temperature sensor with VCO-based readout

Temperature sensors are widely used in microprocessors to monitor on-chip temperature gradients and hot-spots, which are known to negatively impact reliability [1-4]. Such sensors should be: 1) Small to facilitate floor planning; 2) Fast to track millisecond thermal transients and 3) Easy to trim to reduce the associated costs. Recently, it has been shown that thermal diffusivity (TD) sensors can meet these requirements [5]. TD sensors operate by digitizing the temperature-dependent delay associated with the diffusion of heat pulses through an electro-thermal filter (ETF), which, in standard CMOS, can be readily implemented as a resistive heater surrounded by a thermopile. Unlike BJT-based temperature sensors, their accuracy actually improves with CMOS scaling [6], since it is mainly limited by the accuracy of the heater/thermopile spacing, which in turn is determined by lithography. However, the readout circuitry of prior TD sensors has been based on analog phase-domain ΔΣ ADCs, which are not easily ported to low-voltage technologies, and which occupy much more area than the ETF itself [5].
EFFECTS OF TAPER ON SWIMMING FORCE AND SWIMMER PERFORMANCE AFTER AN EXPERIMENTAL TEN‐WEEK TRAINING PROGRAM

The purpose of this research was to examine how an 11-day taper after an 8.5-week experimental training cycle affected lactate levels during maximal exercise, mean force, and performance in training swimmers, independent of shaving, psychological changes, and postcompetition effects. Fourteen competition swimmers with shaved legs and torsos were recruited from the São Paulo Aquatic Federation. The training cycle consisted of a basic training period (endurance and quality phases) of 8.5 weeks, with 5,800 m·d-1 mean training volume and 6 d·wk-1 frequency; and a taper period (TP) of 1.5 weeks' duration that incorporated a 48% reduction in weekly volume without altering intensity. Attained swimming force (SF) and maximal performance over 200-m maximal swim (Pmax) before and after taper were measured. After taper, SF and Pmax improved 3.6 and 1.6%, respectively (p < 0.05). There were positive correlations (p < 0.05) between SF and Pmax before (r = 0.86) and after (r = 0.83) the taper phase. Peak lactate concentrations after SF were unaltered before (6.79 ± 1.2 mM) and after (7.15 ± 1.8 mM) TP. Results showed that TP improved mean swimming velocity, but not in the same proportion as force after taper, suggesting that there are other factors influencing performance in faster swimming.
Rad Tolerant CMOS Image Sensor Based on Hole Collection 4T Pixel Pinned Photodiode

1. 4μm pixel pitch CMOS Image sensors based on hole collection pinned photodiode (HPD) have been irradiated with 60Co source. The HPD sensors exhibit much lower dark current degradation than equivalent commercial sensors using an Electron collection Pinned Photodiode (EPD). This hardness improvement is mainly attributed to carrier accumulation near the interfaces induced by the generated positive charges in dielectrics. The pre-eminence of this image sensor based on hole collection pinned photodiode architectures in ionizing environments is demonstrated.
A new genus of trematodes from the white bass

DiiriiifT the summer of 1919, the writer was engaged in investigations for the United States Bureau of Fisheries upon worm parasites in fishes of the Mississippi River and some of its tributary streams and lakes. Collections were made in Iowa, Hlinois, and Minnesota. In the course of this w^ork some unusual trematodes were encountered in the digestive tract of the white bass, Roccus chrysops (Rafinesque). These, in some superficial respects, resemble members of the genus Acanthochasmus of Looss, but the internal organization differs so pronouncedly from that of any recognized species of Acanthoclid.wius that it becomes necessary to erect a new genus for which the name Allacanthochasmus is proposed. Looss (1899:579) has aptly shown that superficial resemblances are not sound criteria for the determination of phylogenetic relationships between trematode genera when he pointed ©ut the essential differences between the two genera Acanthochasmus and Stephanochasmus. In like manner he called attention to the fundamental differences which exist between these two genera and the genus Ech'mostomum even though all three of these genera display a pronounced crown of oral spines. The presence of conspicuous spines around the oral orifice, though a conspicuous character, is in itself of little or no phylogenetic significance. Accepting this same fundamental hypothesis, Odhner (1911:522) has maintained that the two genera Caecincola and Cryptogonimus are closely related to the genus Acanthochnsmus in spite of the fact that in them oral spines are lacking. On the other hand, in comparing the trematodes from the white bass with others having the oral crown of spines, unique conditions in the relative position of testes, ovary, and uterus and numerous other differences of fundamental im-
In vivo imaging of the cannabinoid CB1 receptor with positron emission tomography

Positron emission tomography (PET) can visualize and quantify receptors and other targets in the living human brain, and recent progress in radioligand development has enabled measurement of cannabinoid type‐1 (CB1) receptors. Cannabinoid CB1 receptors have been implicated in multiple human diseases, such as obesity, mood disorders, and addiction. First in vivo human studies have shown distinctive spatial and temporal alterations in cannabinoid CB1 receptor binding in addictive disorders.
Understanding Memory Dysfunction

Background:Although traditionally memory has been viewed as a simple concept, converging and complementary evidence from patient studies and more recent neuroimaging research suggest that memory is a collection of mental abilities that use different neuroanatomical systems within the brain. Neurologic injury may cause damage to one or more of these memory systems. Review Summary:In this review a number of different memory systems are discussed, including their function, neuroanatomy, and the different disorders that disrupt them. Episodic memory, the most clinically relevant memory system, depends upon the hippocampus and other medial temporal lobe structures, the limbic system, and the frontal lobes. Several other kinds of memory are contrasted with episodic memory, including semantic memory, simple classic conditioning, procedural memory, priming, and working memory. Conclusion:Improved understanding of these different types of memory will aid the clinician in the diagnosis and treatment of the memory disorders of their patients. As more specific therapeutic strategies are developed for the treatment of diseases which cause memory dysfunction, this knowledge will become increasingly important.
Clusterin/apolipoprotein J binds to aggregated LDL in human plasma and plays a protective role against LDL aggregation

Clusterin/apolipoprotein J (apoJ) is an extracellular chaperone involved in the quality control system against protein aggregation. A minor part of apoJ is transported in blood bound to LDLs, but its function is unknown. Our aim was to determine the role of apoJ bound to LDLs. Total LDL from human plasma was fractionated into native LDL [LDL(+)] and electronegative LDL [LDL(‐)]. The latter was separated into nonaggregated [nagLDL(‐)] and aggregated LDL(‐)[agLDL (‐)]. The content of apoJ was 6‐fold higher in LDL(‐) than in LDL(+) and 7‐fold higher in agLDL(‐) than in nagLDL(‐). The proportion of LDL particles containing apoJ (LDL/J+) was 3‐fold lower in LDL(+) than in LDL(‐). LDL/J+ particles shared several characteristics with agLDL(‐), including increased negative charge and aggregation. apoJ‐depleted particles (LDL/J‐) showed increased susceptibility to aggregation, whether spontaneous or induced by proteolysis or lipolysis, as was revealed by turbidimetric analysis, gel filtration chromatography, lipoprotein precipitation, native gradient gel electrophoresis, circular dichroism, and transmission electronic microscopy. The addition of purified apoJ to total LDL also prevented its aggregation induced by proteolysis or lipolysis. These findings point to apoJ as a key modulator of LDL aggregation and reveal a putative new therapeutic strategy against atherosclerosis. —Martínez‐Bujidos, M. , Rull, A. , González‐Cura, B. , Pérez‐Cuéllar, M. , Montoliu‐Gaya, L. , Villegas, S. , Ordóñez‐Llanos, J., Sénchez‐Quesada, J. L. Clusterin/apolipoprotein J binds to aggregated LDL in human plasma and plays a protective role against LDL aggregation. FASEB J. 29, 1688‐1700 (2015). www.fasebj. org
Two Homologous Agr-Like Quorum-Sensing Systems Cooperatively Control Adherence, Cell Morphology, and Cell Viability Properties in Lactobacillus plantarum WCFS1

ABSTRACT A two-component regulatory system of Lactobacillus plantarum, encoded by genes designated lamK and lamR (hpk10 and rrp10), was studied. The lamK and lamR genes encode proteins which are highly homologous to the quorum-sensing histidine kinase LamC and the response regulator LamA, respectively. Transcription analysis of the lamKR operon and the lamBDCA operon and liquid chromatography-mass spectrometry analysis of production of the LamD558 autoinducing peptide were performed for ΔlamA, ΔlamR, ΔlamA ΔlamR deletion mutants and a wild-type strain. The results suggested that lamA and lamR are cooperating genes. In addition, typical phenotypes of the ΔlamA mutant, such as reduced adherence to glass surfaces and filamentous cell morphology, were enhanced in the ΔlamA ΔlamR mutant. Microarray analysis suggested that the same cell wall polysaccharide synthesis genes, stress response-related genes, and cell wall protein-encoding genes were affected in the ΔlamA and ΔlamA ΔlamR mutants. However, the regulation ratio was more significant for the ΔlamA ΔlamR mutant, indicating the cooperative effect of LamA and LamR.
TCAD optimization of a dual N/P-LDMOS transistor

The physical behavior of the dual N/P-LDMOS device concept is reviewed and analyzed. Through a proper optimization, a scalable device with good RSP vs. VBD performance in a range of 20–150 V is identified. Further, the current expansion at high gate and drain biases is fully explained by means of TCAD simulations and nicely exploited for the design of an LDO linear voltage regulator with excellent performance in terms of both drop-out voltage and maximum load current.
Selective Intermixing of InGaAs/GaAs Quantum Dot Infrared Photodetectors

Quantum dot infrared photodetectors have generated significant interest in recent years. They have the potential to outperform quantum well detectors in terms of normal-incidence responsivity and higher operating temperatures. Here, an InGaAs/GaAs dots-in-a-well detector grown by metal-organic chemical vapor deposition is spectrally tuned by rapid thermal annealing under dielectric layers. Four films are considered: SiO2 deposited by both plasma-enhanced chemical vapor deposition and sputter deposition, as well as TiO2 deposited by electron-beam evaporation and sputter deposition. The devices fabricated after these treatments are compared with an uncapped but annealed reference, and also with an as-grown device. The photoresponse peak in the latter occurs at 7.1 μm, whereas the peak responses of the annealed devices range from 7.4 to 11.0 μm. The films themselves were characterized and their properties related to the photoluminescence and spectral photoresponse of each detector. Peak responsivity, specific detectivity, and dark current were also measured for each device to compare their performance.
Preparation and Evaluation of Inclusion Complexes of Commercial Sunscreens in Cyclodextrins and Montmorillonites: Performance and Substantivity Studies

Herein we describe inclusion complexes of commercial sunscreens in cyclodextrins and montmorillonites to generate new sunscreen derivatives with optimized functional properties such as water resistance and skin adherence. Four cyclodextrins (α-, β-, and γ-cyclodextrin, and β-dimethyl cyclodextrin) and two montmorillonites (sodium and alkylammonium) were investigated for encapsulating some commercial sunscreens. Our results reveal a good yield and inclusion products with functional properties obtained by using kneading technique on Eusolex® 2292 and Eusolex® 6007 in β-cyclodextrin and solubilization method on Eusolex® 6007 and NeoHeliopan® MA in montmorillonite. In addition, molecular modeling studies indicated flexibility as important for the intercalation of the host molecule.
A SAR-Based Index for Landscape Changes in African Savannas

Change detection is one of the main applications in earth observation but currently there are only a few approaches based on radar imagery. Available techniques strongly focus on optical data. These techniques are often limited to static analyses of image pairs and are frequently lacking results which address the requirements of the user. Some of these shortcomings include integration of user’s expertise, transparency of methods, and communication of results in a comprehensive understandable way. This study introduces an index describing changes in the savanna ecosystem around the refugee camp Djabal, Eastern Chad, based on a time-series of ALOS PALSAR data between 2007 and 2017. Texture based land-use/land cover classifications are transferred to values of natural resources which include comprehensive pertinent expert knowledge about the contributions of the classes to environmental integrity and human security. Changes between the images are analyzed, within grid cells of one kilometer diameter, according to changes of natural resources and the variability of these changes. Our results show the highest resource availability for the year of 2008 but no general decline in natural resources. Largest loss of resources occurred between 2010 and 2011 but regeneration could be observed in the following years. Neither the settlements nor the wadi areas of high ecologic importance underwent significant changes during the last decade.
Advances in Brief Isolation and Characterization of a Novel Human Gene , DRCTNNB 1 A , the Expression of Which Is Down-Regulated by b-Catenin

b-Catenin plays significant roles in cell-to-cell adhesion and the Wnt/Wg signal transduction pathway. Accumulation of this protein in the cytoplasm and nucleus as a result of mutations of theadenomatous polyposis coli tumor suppressor gene or of theb-catenin gene itself is often seen in a wide variety of tumors including carcinomas of the colon, liver, uterus, and brain. Interaction of accumulatedb-catenin with Tcf/Lef transcription factors is known to deregulate expression of some downstream genes, but the precise mechanisms whereby b-catenin contributes to carcinogenesis remain to be disclosed. Here we report isolation of a novel murine gene, Drctnnb1a (downregulated by Ctnnb1, a), the expression of which was experimentally down-regulated in response to the activated form of b-catenin. To investigate a possible role of DRCTNNB1A in cancers, we also isolated the human homologue,DRCTNNB1A, the deduced product of which was 91% identical to the murine protein. The transcript was expressed in all human tissues examined, and we assigned the genomic location of DRCTNNB1A to chromosomal band 7p15.3 byin situ hybridization. Expression ofDRCTNNB1Ain SW480 colon cancer cells was significantly increased in response to reduction of intracellular b-catenin by adenovirus-mediated transfer of theb-cateninbinding domain of the adenomatous polyposis coli gene into the cells. Furthermore, we documented reduced expression of DRCTNNB1A in 12 of 15 primary colorectal cancers examined, compared with corresponding adjacent noncancerous mucosae. Our results implied that DRCTNNB1A is one of the genes involved in theb-catenin-Tcf/Lef signaling pathway, and that reduced expression ofDRCTNNB1Amay have some role in colorectal carcinogenesis.
Calreticulin expression: Interaction with the immune infiltrate and impact on survival in patients with ovarian and non-small cell lung cancer

ABSTRACT Loss of expression of calreticulin (CALR) has been detected by immunohistochemistry in a fraction of non-small cell lung cancers (NSCLC) and has been demonstrated to have a major negative prognostic impact on overall patient survival. Here, we analyzed the impact of CALR expression levels detected by microarray finding a positive correlation between CALR and the expression of a metagene indicating the presence of cytotoxic T lymphocytes (CTL) in NSCLC and ovarian cancer. In addition, we detected a positive correlation with a metagene suggestive of activated dendritic cell (aDC) infiltration in ovarian cancer. Combination of two parameters (CALR + DC (dendritic cell) in NSCL and CALR + aDC in ovarian cancer) or three parameters (CALR + CTL + DC in NSCL and CALR + CTL + aDC in ovarian cancer) had a significant impact on overall patient survival in NSCL (Adenoconsortium) and ovarian cancer (TCGA collection), allowing the stratification of patients in high-risk and low-risk groups. In addition, CALR and aDC alone have a significant impact on overall survival in ovarian cancer. In contrast, in mammary, colorectal and prostate cancer, CALR had no impact on patient survival if analyzed alone or in combination with the immune infiltrate. In addition, CALR correlates with CTL infiltrate in three cancer types (colorectal, breast, ovarian). Altogether, these results support the contention that, at least in some cancers, loss of CALR expression may negatively affect immunosurveillance, thereby reducing patient survival.
The c‐Rel subunit of nuclear factor‐κB regulates murine liver inflammation, wound‐healing, and hepatocyte proliferation

In this study, we determined the role of the nuclear factor‐kappaB (NF‐κB) subunit c‐Rel in liver injury and regeneration. In response to toxic injury of the liver, c‐Rel null (c‐rel−/−) mice displayed a defect in the neutrophilic inflammatory response, associated with impaired induction of RANTES (Regulated upon Activation, Normal T‐cell Expressed, and Secreted; also known as CCL5). The subsequent fibrogenic/wound‐healing response to both chronic carbon tetrachloride and bile duct ligation induced injury was also impaired and this was associated with deficiencies in the expression of fibrogenic genes, collagen I and α‐smooth muscle actin, by hepatic stellate cells. We additionally report that c‐Rel is required for the normal proliferative regeneration of hepatocytes in response to toxic injury and partial hepatectomy. Absence of c‐Rel was associated with blunted and delayed induction of forkhead box M1 (FoxM1) and its downstream targets cyclin B1 and Cdc25C. Furthermore, isolated c‐rel−/− hepatocytes expressed reduced levels of FoxM1 and a reduced rate of basal and epidermal growth factor–induced DNA synthesis. Chromatin immunoprecipitation revealed that c‐Rel binding to the FoxM1 promoter is induced in the regenerating liver. Conclusion: c‐Rel has multiple functions in the control of liver homeostasis and regeneration and is a transcriptional regulator of FoxM1 and compensatory hepatocyte proliferation. (HEPATOLOGY 2010.)
Two General Branching Patterns of Xyloglucan, XXXG and XXGG

Recent advances in chemical and physical techniques have shed considerable light on the molecular architecture of the primary cell walls of higher plants. According to current models, the primary cell wall is composed of at least two independent polysaccharide networks. The cellulose-xyloglucan network is considered to be an important load-bearing structure of the primary cell wall. Gaps in the cellulose-xyloglucan network are filled by a network of pectic polysaccharides that may control the porosity of the cell wall.
Effects of Fluid Secreted from the Uterus on Duration of Fertile Egg Production in Hens, and Survivability and Penetrability of Fowl Sperm in vitro

1 Science of Bioresource Production, The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima city, Kagoshima 890-0065, Japan 2 Faculty of Agriculture, University of the Ryukyus, Nishihara-cho, Okinawa 903-0213, Japan 3 Faculty of Medicine, University of the Ryukyus, Nishihara-cho, Okinawa 903-0213, Japan 4 Faculty of Agriculture, Kagoshima University, Kagoshima city, Kagoshima 890-0065, Japan 5 Professor Emeritus, Faculty of Agriculture, University of the Ryukyus, Nishihara-cho, Okinawa 903-0213, Japan
DNA sequence and product analysis of the virF locus responsible for congo red binding and cell invasion in Shigella flexneri 2a

The DNA sequence of virF, a locus associated with virulence and the ability to bind Congo red in Shigella flexneri 2a that is located on a 140-megadalton (230-kilobase) plasmid, was determined and analyzed. It was rich in A and T. The direction of transcription of virF was determined by using a chloramphenicol resistance cartridge. An open reading frame readable in this direction was found. Three proteins, 30, 27, and 21 kilodaltons, all corresponding to those predicted from the above sequence, were produced in minicells containing the virF locus. The three proteins were expressed only weakly in minicells with the 230-kilobase plasmid.
Market Efficiency and Price Discovery in the EU Carbon Futures Market

We examine the issues of market efficiency and price discovery in the European Union carbon futures market. Our findings suggest that none of the three carbon futures contracts examined here are priced according to the cost-of-carry model, although two of the three contracts form a stable long-run relationship with the spot price and interest rates, and hence act as adequate risk mitigation instruments. In terms of information diffusion between the futures and spot contracts, it appears that the spot and futures markets share information efficiently and contribute to price discovery jointly. However, our analysis suggests that the predominant source of information spillovers appears to be the sign or direction of price change, i.e. return spillover, rather than the magnitude of price change, i.e. volatility spillover.
Effects of High-Intensity Interval vs. Continuous Moderate Exercise on Intraocular Pressure

Abstract Our purpose was to compare the acute effects of high-intensity interval training (HIT) vs. continuous moderate exercise (CME) on intraocular pressure (IOP) in healthy subjects. Fifteen young men (age=22.1±6 years) underwent 30 min of HIT (2 min of walking at 50% of reserve heart rate (HR) alternated with 1 min of running at 80% of reserve HR) and CME sessions (30 min of jogging/running at 60% of reserve HR) in random order (2–5 days between sessions). IOP was measured before (baseline), immediately after (post-exercise), 5 min after (Rec5) and 10 min after (Rec10) each exercise session. IOP was reduced post-exercise and remained reduced at Rec5 during both HIT and CME session, with no significant difference between interventions (~16% between 23%). However, IOP remained reduced at Rec10 only after HIT intervention (~19%), whereas IOP at Rec10 returned to levels similar to the observed at baseline during CME intervention. In summary, both HIT and CME equally reduced IOP immediately and 5 min after exercise session. However, only HIT was able to remain IOP reduced 10 min after exercise. These results suggest that HIT may be more effective than CME for reducing IOP in young healthy men.