Miracle-dz/UniFAR-FTUs huggingface dataset:
Nanoparticle-imprinted polymers for size-selective recognition of nanoparticles.

Citrate-stabilized gold nanoparticles 15 nm and 33 nm in diameter were transferred concomitantly with a monolayer of positively charged polyaniline by Langmuir-Blodgett transfer at pH 5 onto a conducting indium-doped tin oxide (ITO) support. Films consisting of one to three layers of polyaniline with thicknesses of 1-3 nm were prepared and characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray photoelectron spectroscopy. After electro-oxidation of the Au nanoparticles in 0.1 M KCl, cavities were left behind in the film that could be analyzed by SEM. These cavities were able to recapture analyte nanoparticles from a solution of pH 10 and showed size-exclusion properties. The amount of nanoparticles taken up by the cavities was conveniently analyzed by measuring the charge associated with the electro-oxidation of these particles in 0.1 M KCl after the film had been rinsed with water. The size-exclusion properties improved with the number of Langmuir-Blodgett layers transferred.
Psychiatric Morbidity and Parental Substance Use Disorder

Objective: To assess psychiatric morbidity associated with having no, one, or two parents with Substance Use Disorder (SUD), among patients receiving SUD care. Design: Two measures of psychiatric morbidity included (a) current psychopathology and (b) lifetime use of psychiatric treatment. Settings: Alcohol-drug treatment programs were located in two university medical centers. Subjects: Four hundred ninety-five voluntary patients aged 18 and older and non-adopted. Results: Parental SUD was directly related to (a) more current psychiatric symptoms, both self-rated and psychiatrist-rated and (b) greater likelihood of ever having ever received psychiatric treatment. Among those who had ever received psychiatric care, the number of psychotropic medications was related to parental SUD. Number of admissions, venues, visits/days, and cost of psychiatric care were not associated with parental SUD. Conclusions: Extent of parental SUD was related to increased psychiatric morbidity.
Temporal and spatial expression of TACC1 in the mouse and human

TACC1 is the founding member of the evolutionarily conserved transforming acidic coiled coil genes. These genes play a role in normal development and tumorigenesis through interactions with multiple complexes involved in transcription, translation, and centrosomal dynamics. Despite its importance, detailed examination of the expression of TACC1 and splice variants has not previously been performed. In this study, the spatiotemporal distribution of the Tacc1 protein was examined immunohistochemically in cross‐sections of mouse embryonic tissues. We also report the distribution of currently known/predicted TACC1 splice variants in adult humans. These results indicate that Tacc1 is regulated in a dynamic manner during embryogenesis. In adult humans, ubiquitous expression of at least one TACC1 splice variant is noted, although specific combinations of variants are evident in individual differentiated tissues. An important observation is that in the in vivo three‐dimensional tissue architecture of the growing organism, both the human and mouse TACC1 protein can be localized to different subcellular compartments in a cell‐ and tissue‐specific manner. This indicates that exploration of TACC1 function must take into account the temporal expression of specific splice variants that may perform different cell‐type and tissue‐specific functions. Furthermore, this analysis will provide the groundwork from which future Tacc1 knockout strategies can be designed and properly interpreted. Developmental Dynamics 235:1638–1647, 2006. © 2006 Wiley‐Liss, Inc.
DNA damage detection and repair, and the involvement of epigenetic states

Chromatin is a highly dynamic structure that acts alternately as a substrate and a template in a number of critical biological processes. Modification of chromatin is pertinent and is responsible for a number of nuclear processes, including DNA repair, replication, transcription, and recombination. The purpose of this review is to discuss specific interactions between chromatin remodeling, DNA repair, and transcription. These areas are demonstrated to share commonality, particularly with a number of key molecules that appear to have roles in a number of pathways. The implications of pathway cross‐over and communication form a seamless continuation of genomic integrity and stability. Hum Mutat 25:101–109, 2005. © 2005 Wiley‐Liss, Inc.
AmiGO: online access to ontology and annotation data

AmiGO is a web application that allows users to query, browse and visualize ontologies and related gene product annotation (association) data. AmiGO can be used online at the Gene Ontology (GO) website to access the data provided by the GO Consortium1; it can also be downloaded and installed to browse local ontologies and annotations.2 AmiGO is free open source software developed and maintained by the GO Consortium. Availability: http://amigo.geneontology. org Download: http://sourceforge.net/projects/geneontology/ Contact: sjcarbon@berkeleybop.org
Real‐Time Multi‐View Facial Capture with Synthetic Training

We present a real‐time multi‐view facial capture system facilitated by synthetic training imagery. Our method is able to achieve high‐quality markerless facial performance capture in real‐time from multi‐view helmet camera data, employing an actor specific regressor. The regressor training is tailored to specified actor appearance and we further condition it for the expected illumination conditions and the physical capture rig by generating the training data synthetically. In order to leverage the information present in live imagery, which is typically provided by multiple cameras, we propose a novel multi‐view regression algorithm that uses multi‐dimensional random ferns. We show that higher quality can be achieved by regressing on multiple video streams than previous approaches that were designed to operate on only a single view. Furthermore, we evaluate possible camera placements and propose a novel camera configuration that allows to mount cameras outside the field of view of the actor, which is very beneficial as the cameras are then less of a distraction for the actor and allow for an unobstructed line of sight to the director and other actors. Our new real‐time facial capture approach has immediate application in on‐set virtual production, in particular with the ever‐growing demand for motion‐captured facial animation in visual effects and video games.
Managing knowledge management competency by integrating with collaborative behavior into improving hospitality innovation capability

How firms utilize collaboration on managing resource-based knowledge for innovation is a crucial question for hospitality industry. The purpose of the study is to examine the impacts of knowledge transfer and technical services learning, in enhancing search and acquisition process, on innovation. A 181 stratified hotel sample in Thailand was collected. The findings strongly indicate that knowledge search and acquisition process integrating with knowledge transfer and technical learning have a positive impact on internal innovation. Having more internal capability, firms can then improve service innovation. However, knowledge transfer and technical learning do not affect service innovation. Interestingly, internal innovation does not influence performances directly, but to performances by mediating of service innovation. This study generalizes the understanding in tourism innovation.
Simulation Platform for Opportunistic Radio Systems

Although spectrum is usually considered a scarce resource, measurements have shown that most assigned spectrum is under utilized, and considerable spectrum would be available it both dimensions: space and time are considered in the spectrum management and planning. In most cases there is a spectrum access problem rather than a spectrum shortage. The development ot policy agile terminals that can sense holes in used spectrum and adapt their transmission characteristics to use these holes will provide one tool to address and take advantage ot spectrum under-utilization. In this communication we describe the development ot a simulation tool that addresses the goal of performance evaluation and assessment ot such systems in a coexistence environment with primary cellular networks. The communication presents the main features ot the tool, discusses and proposes metrics to evaluate the capabilities ot the secondary opportunistic networks, and presents illustrative simulation results. These show that even with moderate to high loads in the primary cellular networks, a moderately number of frequencies will allow the deployment ot opportunistic radio networks with very small blocking probabilities
STRUCTURE AND STABILITY OF γ‐CRYSTALLINS‐V. COVALENT AND NONCOVALENT PROTEIN‐PROTEIN INTERACTIONS IN PHOTOSENSITIZED REACTIONS

Abstract— Irradiation of γ‐crystallins with 300 nm light or with the photosensitizers riboflavin or methylene blue (MB) leads to intermolecular cross‐linking and insolubilization. Sodium dodecyl sulfate polyacrylamide gel electrophoresis studies reveal that these cross‐links are composed of nondisulfide covalent bonds. The water‐insoluble phase is stabilized by noncovalent forces, as denaturants readily dissolve it. High‐performance liquid chromatography and electrophoresis results further indicate that the higher multimers are part of this water‐insoluble fraction only, with the exception of MB‐sensitized reactions, which are also able to produce a water‐soluble, high‐molecular‐weight protein of at least 1 million. Labeling the external sulfhydryl groups with iodoacetamide does not prevent the photoreac‐tions; however, a reducing agent such as dithiothreitol does. A mechanism involving initial oxidation and interaction of sulfhydryl groups (forming an intramolecular disulfide) buried within the protein as a necessary precursor to polymerization and precipitation has been proposed in the preceding paper. The present study provides support for this mechanism.
Decentralisation and equity of healthcare provision in Finland

Editorials by Leys and Diderichsen Finland has a comparatively sparse population of 5.1 million in an area of 338 145 km2. Although 66% of the population live in towns, a substantial proportion still lives in rural areas.1 The nation is divided into 452 municipalities, which have a long tradition of local democracy and local elections. The population and area of the municipalities varies from a few hundred inhabitants to large cities with over 100 000 inhabitants, the median population being 6000. Municipalities have a mandate to raise taxes and responsibilities for providing services, and they can form federations covering larger populations. Central government has traditionally guided this process through legislation and state subsidies earmarked for specific services (figure). These subsidies were particularly important when basic services were being provided in remoter and poorer areas, where the maintenance of services is expensive and resources are scarce. In 1993 an act of parliament changed the basis of state subsidies from earmarked to block grants, giving municipalities more independence in using resources. Finance and provision of public health services in Finland excluding care provided by national health insurance and employers. Adapted from Martikainen and Uusilkyla2 #### Summary points In Finland the provision of health services is decentralised and the responsibility of municipalities In practice, central government has traditionally supported these responsibilities through specially allocated funding In the 1990s central government changed to block grants and municipalities have become more independent in providing services Municipalities have tax powers, but in the 1990s they have been increasingly collecting funds through user fees In practice local governance as such may not guarantee equitable access to services or the rights of the most vulnerable groups without legal provision, supervision, and subsidies for poorer areas The Finnish healthcare system has always been comparatively decentralised. Municipalities not only …
What an anticardiovascular diet should be in 2015

Purpose of review Given scientific and public debate about optimal diet to prevent cardiovascular disease, and interest in diet and other chronic diseases, we propose that following a few simple dietary principles would reduce chronic disease incidence. Recent findings Nutrition research has been criticized for focusing on individual nutrients and foods, treated like drug therapy. With a few important exceptions, clinical trials of supplemental nutrients have not shown benefit. Although highly specific nutrition information is elusive, diet patterns have provided consistent answers, important for public health. Observational cohort studies have found that some dietary patterns are reported with high reliability over long periods and predict future cardiovascular and other inflammatory-related diseases. Two randomized clinical trials confirmed this finding. There are many common features of Mediterranean and prudent diets, particularly the plant-centered aspect, coupled with variety of foods eaten. A dietary pattern characterized by high fruit, vegetable, legume, whole grain, nut, berry, seed, and fish intakes, and possibly by intakes of dairy, coffee, tea, chocolate, and alcohol (not in excess), but low meat and detrimentally processed foods is associated with reduced incidence of cardiovascular disease and rates of noncardiovascular, noncancer chronic inflammatory-related mortality. Summary A plant-centered diet may be broadly recommended.
Interaction of the capsid protein p24 (HIV-1) with sequence-derived peptides: influence on p24 dimerization.

Protein-protein interactions of the p24 (HIV-1) capsid protein play an essential role in the production of infectious virus particles. To map the putative p24 dimerization site, a set of overlapping peptides spanning the p24 sequence was prepared using spot synthesis on a cellulose membrane and probed with recombinant p24 (rp24). Three sequence regions interacting with rp24 were identified. Peptides from each region were synthesized, but only one peptide was effectively able to inhibit rp24 dimerization in solution. Amino acids that were exposed in the corresponding p24 region were mutated in rp24, resulting in a significant decrease of rp24 dimerization. Thus, participation of this region in virus capsid assembly can be assumed.
Instrumental Variable Estimation with a Stochastic Monotonicity Assumption

The instrumental variables (IV) method provides a way to estimate the causal effect of a treatment when there are unmeasured confounding variables. The method requires a valid IV, a variable that is independent of the unmeasured confounding variables and is associated with the treatment but which has no effect on the outcome beyond its effect on the treatment. An additional assumption often made is deterministic monotonicity, which says that for each subject, the level of the treatment that a subject would take is a monotonic increasing function of the level of the IV. However, deterministic monotonicity is sometimes not realistic. We introduce a stochastic monotonicity assumption, a relaxation that only requires a monotonic increasing relationship to hold across subjects between the IV and the treatments conditionally on a set of (possibly unmeasured) covariates. We show that under stochastic monotonicity, the IV method identifies a weighted average of treatment effects with greater weight on subgroups of subjects on whom the IV has a stronger effect. We provide bounds on the global average treatment effect under stochastic monotonicity and a sensitivity analysis for violations of stochastic monotonicity.We apply the methods to a study of the effect of premature babies being delivered in a high technology neonatal intensive care unit (NICU) vs. a low technology unit.
Continuous Values of Market Games are Conic

We prove that every continuous value on a space of vector measure market games $Q$, containing the space of nonatomic measures $NA$, has the \textit{conic property}, i.e., if a game $v\in Q$ coincides with a nonatomic measure $\nu$ on a conical diagonal neighborhood then $\varphi(v)=\nu$. We deduce that every continuous value on the linear space $\mathcal M$, spanned by all vector measure market games, is determined by its values on $\mathcal{LM}$ - the space of vector measure market games which are Lipschitz functions of the measures.
Intrapleural Alteplase in a Patient with Complicated Pleural Effusion

OBJECTIVE: To report the intrapleural use of alteplase in a patient diagnosed with complicated pleural effusion (CPE). CASE SUMMARY: A 62-year-old white woman admitted with respiratory distress and hypotension developed a right-sided multi-loculated pleural effusion. Thoracentesis and chest tube drainage were not successful in resolving the effusion. In an attempt to increase the drainage of the pleural effusion, alteplase 16 mg was administered into the pleural cavity via the chest tube on 6 consecutive days. As a result, the volume drained from the patient's chest tube increased, there was improvement on the chest X-ray, and she did not require surgical intervention. DISCUSSION: While streptokinase and urokinase have been shown to be useful adjuncts to chest tube drainage in the treatment of complicated pleural effusion and empyema, there have been no reports on the use of intrapleural alteplase. This report demonstrates that intrapleural administration of alteplase is a useful adjunct to tube drainage in resolving CPE. CONCLUSIONS: This patient's CPE resolved when intrapleural alteplase was used as an adjunct to chest tube drainage and antibiotics. Controlled trials need to be conducted to investigate fully the efficacy, dosing, and safety of intrapleural alteplase in the treatment of patients with CPE and empyema.
Older patients with chronic heart failure within Swedish community health care: a record review of nursing assessments and interventions.

BACKGROUND Older patients with chronic heart failure constitute a large group within community home care that is at high risk for re-hospitalization. However, hospital readmission can be prevented if early signs of deterioration are recognized and proper interventions applied. AIMS AND OBJECTIVES The aim of the study was to audit nursing care for older chronic heart failure patients within the Swedish community health care system. DESIGN The study adopted a retrospective descriptive design. METHODS In a Swedish urban municipality nursing documentation from 161 records on patients diagnosed with chronic heart failure was collected retrospectively from community nursing home care units. Patient records were reviewed for characteristics of nursing care and assessed for comprehensiveness in recording. RESULTS The main results showed that medical care of patients with chronic heart failure was poorly recorded, making it possible only to follow fragments of the care process. The nursing notes showed poor adherence to current clinical guidelines. Only 12% of the records contained notes on patients' body weight and only 4% noted patients' knowledge about chronic heart failure. When interventions did occur, they largely consisted of drug administration. CONCLUSIONS The findings revealed flaws in the recording of specific assessment and interventions as well as poor adherence to current international clinical guidelines. RELEVANCE TO CLINICAL PRACTICE Supportive guidelines available at the point of care are needed to enhance proper community-based home health care for older patients with chronic heart failure.
Cortical Thickness: Practicalities and Comparisons

In Part I, some practical aspects of cortical thickness analysis are examined, using the software package Freesurfer. Repeatability of surface measurements and intra-subject surface alignment are tested, and optimization is discussed. In Part II, the thickness measurements generated by Freesurfer are compared with the thickness measurements generated by solving Laplace's Equation in the cortical ribbon.
Online Classification Algorithm for Data Streams Based on Fast Iterative Kernel Principal Component Analysis

Several dimensionality-reduction techniques based on component analysis (CA) have been suggested for various data stream classification tasks and allow fast approximation. The variations of CA, such as PCA, KPCA and ICA, however, have limited dimensionality-reduction ability because of their high complexity or linear transformation scheme, etc. This paper proposes a fast iterative kernel principal component analysis algorithm: FIKDR, which non-linearly, iteratively extracts the kernel principal components with only linear order computation and storage complexity per iteration. On the basis of FIKDR, this paper proposes an online classification algorithm for data stream: FIKOCFrame. The convergence analysis confirms the validity of FIKDR and extensive experiments confirm the superiority of FIKOCFrame over recent classification schemes based on CA.
Disks around O-type young stellar objects

Accretion disks are one of the key ingredients of the star formation process. They redistribute angular momentum and, in the case of high-mass stars (M > 8Msun), disks would relieve the radiation pressure on the accreting material, in particular in the equatorial direction, by beaming the radiation through the poles of the system and this would allow the accretion to proceed onto the central protostar (e.g., Tan et al. 2014 for a review on massive star formation). In fact, in recent years, all high-mass star-forming theories appear to converge to a disk-mediated accretion scenario (e.g., Krumholz et al. 2007; Kuiper et al. 2011; Bonnell & Bate 2006; Keto 2007) but do the observations of high-mass young stellar objects (YSOs) confirm the theory predictions? Or in other words, do true accretion disks around massive stars really exist?