Miracle-dz/UniFAR-FTUs huggingface dataset:
Study of the sleep patterns, sleep habits, and sleep problems in Japanese elementary school children using the CSHQ-J

Objective: This study aimed to examine the sleep patterns, sleep habits, and sleep problems in Japanese elementary school children from the aspect of their developmental age. Methods: The Japanese version of the Children's Sleep Habits Questionnaire (CSHQ-J) was distributed to the parents of 330 students of which 296 (154 boys and 142 girls) questionnaires were returned. The subjects were divided into 3 groups by grade (Low-grade [1st−2nd graders], Middle-grade [3rd−4th graders], and High-grade [5th−6th graders]). Results: Bedtime was significantly later and sleep duration was significantly shorter in the older students. The total CSHQ-J score was significantly higher in the Low-grade group compared with that in the High-grade group. Regarding the sub-items of the CSHQ-J, the scores for "bedtime resistance" and "sleep anxiety" were significantly higher in the Low-grade group compared with those in the High-grade group. Conclusions: That sleep duration was significantly shorter in the older students was attributable to their later bedtimes. Differences in the total and sub-item scores of the CSHQ-J were largely attributable to the autonomy of sleep.
Refugee Camps in the Palestinian and Sahrawi National Liberation Movements: A Comparative Perspective

Drawing on ethnographic field research, this analysis compares the evolution of refugee camps as incubators of political organization and repositories of collective memory for Palestinian refugees in Jordan and Sahrawi refugees of the Western Sahara. While recognizing the significant differences between the historical and geopolitical contexts of the two groups and their national movements (the PLO and Polisario, respectively), the author examines the Palestinian and Sahrawi projects of national consciousness formation and institution-building, concluding that Palestinian camps are ““mapped”” in relation to the past, while political organization in Sahrawi camps evidences a forward-looking vision.
Analysis of Free-Storage Algorithms - Revisited

Most research in free-storage management has centered around strategies that search a linked list and strategies that partition storage into predetermined sizes. Such algorithms are analyzed in terms of CPU efficiency and storage efficiency. The subject of this study is the free-storage management in the Virtual Machine/System Product (VM/SP) system control program. As a part of this study, simulations were done of established, and proposed, dynamic storage algorithms for the VM/SP operating system. Empirical evidence is given that simplifying statistical assumptions about the distribution of interarrival times and holding times has high predictive ability. Algorithms such as first-fit, modified first-fit, and best-fit are found to be CPU-inefficient. Buddy systems are found to be very fast but suffer from a high degree of internal fragmentation. A form of extended subpooling is shown to be as fast as buddy systems with improved storage efficiency. This algorithm was implemented for VM/SP, and then measured. Results for this algorithm are given for several production VM/SP systems.
HISTO-MORPHOMETRIC AND HISTOCHEMICAL COMPARATIVE STUDY OF THE LIVER IN COLLARD DOVE (Frivaldszky), RUDDY SHELDUCK (Pallas) IN SOUTH IRAQ.

The results of present study showed that the liver of the Collard Dove and Ruddy Shelduck was covered by a thick connective tissue capsule, formed of collagen fibers and some reticular fibers. Hepatocytes were arranged as irregular anastomosing cords of two cells. The cords were separated from each other's by blood sinusoids. The hepatocytes were large polygonal cells with large rounded nuclei. The portal triads containing branches of hepatic artery, portal vein, bile duct and lymph vessels.
Resampling Dependent Concordance Correlation Coefficients

The concordance correlation coefficient (CCC) is a popular index for measuring the reproducibility of continuous variables. We examine two resampling approaches, permutation testing and the bootstrap, for conducting hypothesis tests on dependent CCCs obtained from the same sample. Resampling methods are flexible, require minimal marginal and joint distributional assumptions, and do not rely on large sample theory. However, the permutation test requires a restrictive assumption (exchangeability) which limits its applicability in this situation. Simulation results indicate that inference based on the bootstrap is valid, although type-I error rates are inflated for small sample sizes (≈30). For illustration we analyze data from a carotid stenosis screening study.
Anti-hyperalgesic effect of Mangifera indica L. extract on the sciatic chronic constriction injury model in rats

Context: The aqueous extract of Mangifera indica L. stem bark (MSBE) shows antioxidant, anti-inflammatory and analgesic properties. Aims: To test the MSBE in chronic constriction injury (CCI) of the sciatic nerve in rats, a classical model of neuropathic pain. Methods: Given the possibility that some clinical effect of MSBE can appear only after its chronic administration, we designed a long term medication protocol with 500 mg/kg, p.o. or distilled water daily during 8 days from 9 days post-CCI. Pregabalin (10 mg/kg, p.o.) was used as reference drug. Sham CCI animals received vehicle. Behavioral tests were carried out before CCI, at 9 and 16 days after injury. A section of sciatic nerve, 5 mm distal to the ligature site was dissected for histopathological studies. A single oral similar dose or vehicle was administered to mononeuropathic rats, 14 days after surgery. Mechano-hyperalgesia and thermal hyperalgesia of the ipsilateral paw were determined using a modification of pin prick method and the unilateral hot plate, respectively before CCI, 0, 30, 60, 120 and 180 min post-administration. Results: Repeated oral MSBE doses reduced nociceptive score, increased paw withdrawal latency and attenuated CCI-induced Wallerian degeneration-related changes involved in the hyperalgesic state of CCI rats. Likewise, MSBE shows significant mechanical and thermal anti-hyperalgesic effect from 1h after its single administration. Conclusions: The study of MSBE should be focused in neuropathic pain models since this natural product could have a clinical relevance in the treatment of neuropathic pain syndromes.
Study of the Influence of Stray Magnetic Fields on the Operation of the European Gyrotron for ITER

In this paper, the influence of stray magnetic fields (SMFs) in the ITER electron cyclotron resonance heating and current drive (ECRH-CD) building on the operation of the European (EU) 170 GHz, 1 MW, continuous wave gyrotrons is investigated. There are mainly two sources of SMF in the ITER ECRH-CD building: 1) the tokamak and 2) the neighboring gyrotrons which are placed in close proximity. The possible electron beam degradation caused by the influence of the SMF is numerically investigated. Furthermore, the collector operation under the influence of an SMF is also studied. A proposal to compensate the influence of the SMF is discussed.
Mutational Analysis of the Transcription Factor IIIB-DNA Target of Ty3 Retroelement Integration*

The Ty3 retrovirus-like element inserts preferentially at the transcription initiation sites of genes transcribed by RNA polymerase III. The requirements for transcription factor (TF) IIIC and TFIIIB in Ty3 integration into the two initiation sites of the U6 gene carried on pU6LboxB were previously examined. Ty3 integrates at low but detectable frequencies in the presence of TFIIIB subunits Brf1 and TATA-binding protein. Integration increases in the presence of the third subunit, Bdp1. TFIIIC is not essential, but the presence of TFIIIC specifies an orientation of TFIIIB for transcriptional initiation and directs integration to the U6 gene-proximal initiation site. In the current study, recombinant wild type TATA-binding protein, wild type and mutant Brf1, and Bdp1 proteins and highly purified TFIIIC were used to investigate the roles of specific protein domains in Ty3 integration. The amino-terminal half of Brf1, which contains a TFIIB-like repeat, contributed more strongly than the carboxyl-terminal half of Brf1 to Ty3 targeting. Each half of Bdp1 split at amino acid 352 enhanced integration. In the presence of TFIIIB and TFIIIC, the pattern of integration extended downstream by several base pairs compared with the pattern observed in vitro in the absence of TFIIIC andin vivo, suggesting that TFIIIC may not be present on genes targeted by Ty3 in vivo. Mutations in Bdp1 that affect its interaction with TFIIIC resulted in TFIIIC-independent patterns of Ty3 integration. Brf1 zinc ribbon and Bdp1 internal deletion mutants that are competent for polymerase III recruitment but defective in promoter opening were competent for Ty3 integration irrespective of the state of DNA supercoiling. These results extend the similarities between the TFIIIB domains required for transcription and Ty3 integration and also reveal requirements that are specific to transcription.
Gold sodium thiomalate treatment of pemphigus.

Pemphigus is a disease associated with a high death rate if untreated and a high morbidity rate when treated with corticosteroids administered systemically for a prolonged period. Parenterally administered gold sodium thiomalate was evaluated in 18 patients as an alternate means of therapy. Fourteen of these patients (three of whom had never received systemic corticosteroids for this condition) have been successfully managed for variable periods with this drug.
Naturally Occurring Major and Minor Capsid Protein Variants of Human Papillomavirus 45 (HPV45): Differential Recognition by Cross-Neutralizing Antibodies Generated by HPV Vaccines

ABSTRACT We investigated naturally occurring variation within the major (L1) and minor (L2) capsid proteins of human papillomavirus genotype 45 (HPV45). Pseudoviruses (PsVs) representing HPV45 sublineages A1, A2, A3, B1, and B2 exhibited comparable particle-to-infectivity ratios and morphologies but demonstrated both increased (A2, A3, and B1) and decreased (B2) sensitivities to cross-neutralization by HPV vaccine antibodies compared to that of the A1 sublineage. Mutant PsVs identified HI loop residue 357 as being critical for conferring this differential sensitivity.
Microsatellite multiplexes for the genetic analyses of northern pike (Esox lucius) populations

Abstract The northern pike (Esox lucius L.) is a commercially important fish that forms freshwater and brackish populations. While the first ecotype is still quite abundant, the second has suffered rapid declines in recent years. Populations inhabiting the Baltic coastal waters of Poland have been supported by stocking programs since the late 1990s. This study describes a multiplex microsatellite (msDNA) assay consisting of 12 loci divided conveniently into two amplification sets (Elu78, Elu87, B451, Elu37, B457, B16, B25, and Elu19, Elu76, B422, Elu2, Elu7). The assay was optimized for genetic analyses of freshwater and brackish populations. These multiplexes were successfully executed to obtain the genetic profiles of 668 individuals from 16 populations (Poland and Germany). The average number of alleles was equal to 10.4, whereas the observed heterozygosity per locus ranged from 0.18 to 0.89, with the average value of 0.64. The probability of the identity of the marker sets indicated the high power of identification of unique genotypes. Therefore, this molecular tool can be used to describe the genetic variability of populations, select the proper source of breeding material, and monitor the progress of stocking efforts in genetic conservation projects of this species.
WiSE – a satellite‐based system for remote monitoring

Recent technological advancements in sensors, processors and communications technology make it viable to perform digital acquisition of environmental data from remote locations. Declining costs and miniaturisation of electronics and sensors have enabled design of systems for intelligent remote monitoring. These advances pave the way for new tools to support field work by virtually extending researchers' reach to the field study area from the comfort of their offices. The Wireless Internet Sensing Environment project developed an architecture providing control and retrieval of data from networked sensors and cameras at a remote location using Internet backhaul. Satellite connectivity enabled this equipment to be deployed to remote locations to support an ecological application. This paper describes architecture and innovative design features for this challenging problem space, including motion event detection, power management and a method to upload collected data. © 2016 The Authors. International Journal of Satellite Communications and Networking published by John Wiley & Sons Ltd.
miRNA-145 Targets v-ets Erythroblastosis Virus E26 Oncogene Homolog 1 to Suppress the Invasion, Metastasis, and Angiogenesis of Gastric Cancer Cells

Recent evidence shows that v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) is implicated in tumor development and progression. However, the clinical potentials and underlying mechanisms of Ets1 in gastric cancer progression and metastasis remain largely unknown. In this study, Ets1 immunostaining was identified in 56 of 84 (66.7%) gastric cancer tissues, which was correlated with tumor invasion and metastasis. In gastric cancer specimens and cell lines, miRNA-145 (miR-145) was downregulated and inversely correlated with Ets1 expression. Bioinformatics analysis and luciferase reporter assay revealed that miR-145 directly targeted the 3′-untranslated region (3′-UTR) of Ets1 mRNA. Overexpression or knockdown of miR-145 responsively altered both the mRNA and protein levels of Ets1 and its downstream genes, matrix metalloproteinase (MMP-1)-1 and -9, in gastric cancer cell lines SGC-7901 and MKN-45. Ectopic expression of miR-145 suppressed the invasion, metastasis, and angiogenesis of SGC-7901 and MKN-45 cells in vitro and in vivo. In addition, the effects of miR-145 on Ets1 expression, migration, invasion, and angiogenesis were rescued by restoration of Ets1 expression in these cells. Furthermore, anti-miR-145 inhibitor promoted the migration, invasion, and angiogenesis, whereas siRNA-mediated Ets1 knockdown phenocopied the effects of miR-145 overexpression in gastric cancer cells. These results show that miR-145 suppresses Ets1 expression via the binding site in the 3′-UTR, thus inhibiting the invasion, metastasis, and angiogenesis of gastric cancer cells. Mol Cancer Res; 11(2); 182–93. ©2012 AACR.
Endogenous lithium clearance: a diagnostic method of assessing sodium sensitivity in hypertension. Methodological and clinical implications.

1Department of Internal Medicine and Gerontology, Medical College, Jagiellonian University, Krakow, Poland 2Department of Nephrology, Hypertension and Internal Diseases, Chair of Internal Diseases, Faculty of Medicine, University of Warmia and Mazury, Olsztyn, Poland 3Trace Element Research Laboratory, Department of Food Chemistry and Nutrition, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, Poland
The effect of the Slow-Stroke back massage on fatigue of dialyzed patients

Fatigue is the most common side effect that is known as one of the most stressful factors, and it is expressed as a debilitating factor, aim of this study was to study the effect of back massage on fatigue in hemodialysis patients by Slow-Stroke method. This study is available as clinical trial with 60 simple examples; it was done in the city of Ardabil in BuAli hospital in dialysis ward on hemodialysis patients. The Piper Fatigue Scale questionnaire in three times (starting days 15th and thirtieth) was completed by both groups. Finally, the results were analyzed spss 13 software. Descriptive statistics and analysis of variance tests, Repeat Measures ,Independent Samples T Test were used to analyze data and to communicate results. The results showed that there is significantly different between the different groups tested at baseline and end of study (P =003/0), and there was not observed significant differences the start up time of 15 days to 15 days of the end of the study. The analysis of variance showed that among the groups at the end of the study there was a significant difference (0/ 05>P). This study showed that massage therapy for 30 days resulted in a reduction in fatigue and to feel comfort by patients.
Idiopathic Lumbosacral Neuropathy Syndrome: Case Report

Idiopathic lumbosacral plexitis or lumbosacral radiculoplexus neuropathy is a disease characterized by nerve damage in lumbar and/or sacral plexus without trauma, mass effect or diabetic complications. A 47-year-old male patient with right groin pain and loss of right leg muscle strength is presented in this case report. Neuropathy was detected in the L4 nerve root by electromyography and magnetic resonance neurrographic imaging. The underlying cause was investigated; however, it is linked to the idiopathic outcome. Idiopathic lumbosacral neuropathy is a lumbosacral plexus disease in which no underlying pathology plays a role in causing severe pain and muscle weakness. Patients should be avoided urgently operation because of the sudden onset symptoms.
Accelerating Norm Emergence Through Hierarchical Heuristic Learning

Social norms serve as an important mechanism to regulate the behaviours of agents and to facilitate coordination among them in multiagent systems. One important research question is how a norm can rapidly emerge through repeated local interaction within agent societies under different environments when their coordination space becomes large. To address this problem, we propose a hierarchically heuristic learning strategy (HHLS) under the hierarchical social learning framework. Subordinate agents report their information to their supervisors, while supervisors can generate instructions (rules and suggestions) based on the information collected from their subordinates. Subordinate agents heuristically update their strategies based on both their own experience and the instructions from their supervisors. Extensive experiment evaluations show that HHLS can support the emergence of desirable social norms more efficiently and can be applicable in a much wider range of multiagent interaction scenarios compared with previous work. The influence of key related factors (e.g., different topologies, population, neighbourhood and action space size, cluster size) are also investigated and new insights are obtained as well.
The complete chloroplast genome of Malania oleifera (Olacaceae), an endangered species in China

Abstract Malania oleifera is a rare and threatened medicinal plant in China. In this study, the complete chloroplast genome (cp) of M. oleifera was sequenced, assembled, and analyzed. The circular complete cp genome of M. oleifera was 158,163 bp in length and contained a large single copy region (LSC, 87,212 bp), a small single copy region (SSC, 439 bp), and 2 short inverted repeat (IRa and IRb) regions (35,256 bp). The cp genome encodes 97 unique genes, including 62 protein-coding genes, 30 transfer RNA genes, 4 ribosomal RNA genes, and a pseudogene. Phylogenetic analysis of M. oleifera showed that M. oleifera was the sister group with Champereia manillana from Opiliaceae and Osyris alba from Santalaceae.
Molecular Typing of Mycobacterium tuberculosis Based on Variable Number of Tandem DNA Repeats Used Alone and in Association with Spoligotyping

ABSTRACT Fingerprinting based on variable numbers of tandem DNA repeats (VNTR), a recently described methodology, was evaluated for molecular typing of Mycobacterium tuberculosis in an insular setting. In this study, VNTR fingerprinting was used alone or as a second-line test in association with spoligotyping, double-repetitive-element PCR (DRE-PCR), and IS6110restriction fragment length polymorphism (RFLP) analysis, and the discriminatory power for each method or the combination of methods was compared by calculating the Hunter-Gaston discriminative index (HGI). The results obtained showed that in 6 out of 12 (50%) cases, VNTR-defined clusters were further subdivided by spoligotyping, compared to 7 out of 18 (39%) cases where spoligotyping-defined clusters were further subdivided by VNTR. When used alone, VNTR was the least discriminatory method (HGI = 0.863). Although VNTR was significantly more discriminatory when used in association with spoligotyping (HGI = 0.982), the combination of spoligotyping and DRE-PCR (HGI = 0.992) was still the most efficient among rapid, PCR-based methodologies, giving results comparable to IS6110 RFLP analysis. Nonetheless, VNTR typing may provide additional phylogenetical information that may be helpful to trace the molecular evolution of tubercle bacilli.
Genetic Diversity of Introduced (Pomacea canaliculata) and Native (PILA) Apple Snails in Thailand Revealed by Randomly Amplified Polymorphic DNA (RAPD) Analysis

Genetic diversity of the introduced golden apple snail, Pomacea canaliculata (Lamarck, 1822) and four native apple snails; Pila ampullacea (Linneaus, 1758), P. angelica (Annandale, 1920), P. pesmei (Morelet, 1889) and P. polita (Deshayes, 1830) in Thailand were studied by RAPD analysis. Two hundred and two polymorphic fragments (180-1500 bp in length) were generated across overall investigated samples (N = 254) using three informative primers (OPA07, OPB10 and UBC122). The percentages of polymorphic bands were 98.86%, 94.56%, 90.91%, 96.94% and 95.51% for Pomacea canaliculata, P. ampullacea, P. angelica, P. pesmei and P. polita, respectively. This indicated high genetic polymorphism of these taxa. A neighbor-joining tree between pairs of geographic samples within Pomacea canaliculata suggested a lack of phylogeography in this species. Moreover, candidate species-specific RAPD markers (pKUSCARPILA-F/R) found in Pomacea canaliculata (340 bp, OPB10), P. ampullcea (640 bp, OPA07), P. angelica (380 bp, UBC122) and Pila snails (430 bp, OPA07) were cloned and sequenced. Locus-specific primers were designed and tested against the target and nontarget species. A 259 bp SCAR marker was found in 95.0% of Pila apple snails (N = 163) but not in Pomacea canaliculata (N = 30). Therefore, this SCAR marker could be used in coupling with a Pomacea canaliculata-specific RAPD marker to unambiguously differentiate the introduced and native apple snails in Thailand.
Polymorphisms in CYP2A13 and UGT1A7 genes and head and neck cancer susceptibility in North Indians.

OBJECTIVES To examine role of genetic variants of CYP2A13 and UGT1A7 genes, involved in activation and detoxification of tobacco carcinogens, with risk of head and neck cancer as well as to assess the potential modifying role of gene-gene and gene-environment interactions. METHODS 203 head and neck cancer patients and 201 healthy controls were genotyped for functional polymorphisms of CYP2A13 and UGT1A7 genes using polymerase chain reaction-restriction fragment length polymorphism, denaturing high-performance liquid chromatography and sequencing. RESULTS We identified two novel polymorphisms T478C and T494C in CYP2A13 gene which were associated with significantly reduced risk of cancer (OR 0.37; 95% CI 0.19-0.71; P < 0.05). A CYP2A13 haplotype carrying variant alleles of T478C/T494C was found to be associated with reduced risk of head and neck cancer (OR 0.42; 95% CI 0.22-0.78; P = 0. 005). Mutant 'T' allele of CYP2A13 C578T polymorphism was found to be present in cancer patients only. A sevenfold increased risk of cancer was observed in smokers with UGT1A7 low activity genotypes (OR 7.01; 95% CI 1.02-48.37; P < 0.05). UGT1A7 haplotype carrying C allele (T622C) showed 10-fold increased risk of cancer (OR 10.12; 95% CI 1.29-79.4; P < 0.05). CONCLUSION Interplay between genetic variants of CYP2A13 and UGT1A7 genes and smoking may modulate susceptibility to head and neck cancer.