Miracle-dz/UniFAR-FTUs huggingface dataset:
Parietal Damage and Narrow Spotlight Spatial Attention

Patients with parietal volume loss showed electrophysiological and behavioral signs of abnormally narrow regions of enhancement of sensory stimulation at an attended location. On a test of focused spatial attention, when compared to normal control subjects and patients without parietal abnormality, patients with abnormalities of parietal cortex demonstrated (1) faster button press RTs to targets, (2) earlier P3b event-related potential (ERP) latencies to targets, and (3) larger than normal P1 ERP attention effects (i.e., greater than normal enhancement of sensory responses at an attended location). These data are evidence for visual attention distributed as a spotlight at the attentional focus with little surrounding processing enhancement. This dysfunctional attentional map facilitates simple responses within the attentional beam quite well, but could hinder responses outside the beam. Severely gated sensory responses outside the immediate attentional focus are likely to result in severely delayed responses to information in those locations. This would be consistent with the response delays seen in patients with parietal damage following an incorrect spatial cue (extinction-like pattern), and also with clinical observations of inattention in such patients. The patterns of sensory enhancement seen in these data suggest a mechanism that may underlie the impairments in spatial attention that follow damage to parietal cortex, and help to specify the role of parietal cortex in spatial attention.
cDNA Cloning and Molecular Characterization of Human Brain Metalloprotease MP100

Abstract : Metalloprotease MP100 was originally isolated as a β‐secretase candidate from human brain using a β‐amyloid precursor protein (β‐APP)‐derived p‐nitroanilide (pNA) peptide substrate. Peptide sequences from purified MP100 were now found to resemble sequences reported for a puromycin‐sensitive aminopeptidase (PSA) highly enriched in brain, and cDNA cloning revealed nearly complete homology of MP100 to PSA, with only a single bp difference resulting in an amino acid change at position 184. Another MP100 cDNA encoded a protein with a 36‐amino acid deletion (positions 180‐217) and a two‐amino acid insertion after Val533. Purified recombinant human MP100 cleaved the original pNA substrate as well as a free β‐site‐spanning amyloid β (Aβ) peptide (Aβ‐10/+10), generating Aβ1‐10. The latter substrate, however, remained uncleaved, if N‐ and C‐terminally blocked, and also purified β‐APP was not cleaved. Double immunoimaging revealed partial, patchy, colocalization of β‐APP and MP100 in doubly transfected human embryonic kidney cells (HEK cells) and in normal neuroblastoma cells, and both proteins could be coimmunoprecipitated from rat brain extracts, suggesting their close vicinity in vivo. Coexpression of MP100 and β‐APP695, however, did not boost Aβ levels in HEK cells, although active enzyme was produced. Thus, MP100 does not exert true β‐secretase‐like function in cells, although it may well act as a secondary exoprotease in a complex β‐APP/Aβ metabolism.
Gender representation and social justice: ideology, methodology and smoke-screens

A number of researchers have provided an overview of the progress of research focusing on gender and educational leadership/management in the twentieth and twenty-first centuries. Some cast studies of representation as an early phase overtaken by later concern with phenomenological and radical perspectives. More recently, a focus on women and equity of representation within the workplace has been attacked as inappropriately essentialising women or as redundant in the light of advances in gender equality. This paper reviews the purpose and nature of descriptions of gender representation in educational leadership and links to ideological and power flows. It also describes one international effort to make progress in understanding the experience of women school principals within the Commonwealth and explores the significance of the difficulties encountered.
A Continuous-Grain Silicon-System LCD With Optical Input Function

In this paper, we describe a continuous-grain silicon-system LCD with integrated optical input function for application in next-generation mobile devices. The optical input function, which may be used for touch input or fingerprint-recognition applications, is achieved by integrating image-sensor elements within each display pixel. By using a one-transistor (IT) active pixel sensor, we have successfully integrated a 30 Hz, 300 dpi VGA image sensor within an LCD panel with an aperture ratio of 40%. Power consumption and circuit area in the panel are minimized through the use of a source driver circuit which combines the functions of both display and sensor.
Two-dimensional nonlinear spin-dipole waves in the millimeter wave range

Propagation of nonlinear exchangeless spin-dipole waves in the millimeter wave range (f /spl sim/ 35-60 GHz) in ferrite films is investigated. A method for a derivation of nonlinear equation for the wave envelope based on the general theory of excitation of waveguides has been applied. This gives a possibility to obtain rigorously the nonlinear terms including the nonlinearity dispersion. A propagation of the nonlinear spin-dipole wave along the direction of the bias magnetic field is considered (backward volume waves). The range of wave numbers where the soliton propagation and of the collapse phenomena can occur has been specified. The numerical simulations have demonstrated a possibility of strong spatial-temporal compression of the input pulse.
Comparative Risk and Perceived Control: Implications for Psychological and Physical Well-Being Among Older Adults

As older adults become more susceptible to certain health crises, their preoccupation with their risk of suffering such events increases. Understanding the implications of risk perceptions is critical because they may have consequences for psychological and physical well-being in later life. In the present study of older adults living in the community, the authors examined participants' comparative risk estimates (CREs)—their perceptions of their own risk relative to a similar other's risk—of suffering a hip fracture. Using multiple regression analyses, the authors examined the role of CREs on psychological well-being (negative emotions, life satisfaction) and self-rated physical well-being (general physical health, recent physical health). The authors expected perceived control (PC) to moderate the relationship between CREs and well-being. The predicted interaction did occur: Among individuals with high PC, comparative optimism (perceiving a comparatively low risk) was associated with better psychological well-being (fewer negative emotions and greater life satisfaction) and better physical well-being (general and recent physical health) relative to comparative pessimism (perceiving a comparatively high risk). Among individuals with low PC, there were no differences in well-being between comparative optimists and comparative pessimists. These findings suggest that the protective effect of comparative optimism on well-being is limited to older adults who have a strong sense of control.
n-Butyl 2-(3-chloro-1,2-dihydropyrazin-2-ylidene)-2-cyanoacetate

The title compound, C11H12ClN3O2, is essentially planar except for the n-butoxy group [r.m.s. deviation from the least-squares plane = 0.0131 (1) Å for 11 non-H atoms]. An intramolecular N—H⋯O interaction results in the formation of an S(6) ring. The n-butoxy chain in the molecule is disordered over two sets of sites of equal occupancy.
Simultaneous White Noise Models and Optimal Recovery of Functional Data

Simultaneous White Noise Models and Optimal Recovery of Functional Data Mark Koudstaal Doctor of Philosophy Graduate Department of Statistics University of Toronto 2015 We consider i.i. d. realizations of a Gaussian process on [0, 1] satisfying prescribed regularity conditions. The data consist of discrete samplings of these realizations in i.i. d. Gaussian noise and the goal is estimation of the underlying trajectories. Further, we want our estimates to enjoy expected L2 errors, conditioned on the realized trajectories, which attain optimal rates. Under general conditions on both design and process, an asymptotic equivalence, in Le Cam’s sense, is established between an experiment which simultaneously describes these realizations and a collection of white noise models. The risk properties of our estimation goal may then be studied in an idealized setting and benchmarks established for practically implementable procedures. In this context, the white noise models are projected onto a basis satisfying general conditions in relation to the covariance kernel of the process which generated the data. This reduces the problem of initial interest to that of recovering a collection of normal means in euclidean norm, the means of interest having Gaussian structure. A variant of Stein estimation is applied for recovery of these means and a key inequality derived showing that the corresponding risks, conditioned on the underlying means, can be made arbitrarily close to those that an oracle with knowledge of the process would attain. This establishes various notions of optimality for our recovery procedure.
Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair

ABSTRACT Repair of damaged DNA is critical for maintenance of genetic information. In eukaryotes, DNA double-strand breaks (DSBs) are recognized by the Ku70-Ku80 heterodimer, which then recruits proteins that mediate repair by nonhomologous end joining (NHEJ). Prolonged retention of Ku70/80 at DSBs prevents completion of repair, however, with ubiquitylation of Ku80 having been implicated in Ku70/80 dissociation from DNA. Here, we identify RNF126 as a ubiquitin ligase that is recruited to DSBs and ubiquitylates Ku80, with UBE2D3 serving as an E2 enzyme. Knockdown of RNF126 prevented Ku70/80 dissociation from DSBs and inhibited break repair. Attenuation of Ku80 ubiquitylation by replacement of ubiquitylation site lysines with arginine residues delayed Ku70/80 release from chromatin after DSB induction by genotoxic insults. Together, our data indicate that RNF126 is a novel regulator of NHEJ that promotes completion of DNA repair by ubiquitylating Ku80 and releasing Ku70/80 from damaged DNA.
General Privacy-Preserving Verifiable Incentive Mechanism for Crowdsourcing Markets

In crowdsourcing markets, there are two different type jobs, i.e. homogeneous jobs and heterogeneous jobs, which need to be allocated to workers. Incentive mechanisms are essential to attract extensive user participating for achieving good service quality, especially under a given budget constraint condition. To this end, recently, Singer et al. propose a novel class of auction mechanisms for determining near-optimal prices of tasks for crowdsourcing markets constrained by the given budget. Their mechanisms are very useful to motivate extensive user to truthfully participate in crowdsourcing markets. Although they are so important, there still exist many security and privacy challenges in real-life environments. In this paper, we present a general privacy-preserving verifiable incentive mechanism for crowdsourcing markets with the budget constraint, not only to exploit how to protect the bids and assignments' privacy, and the chosen winners' privacy in crowdsourcing markets with homogeneous jobs and heterogeneous jobs and identity privacy from users, but also to make the verifiable payment between the platform and users for crowdsourcing applications. Results show that our general privacy-preserving verifiable incentive mechanisms achieve the same results as the generic one without privacy preservation.
Paenibacillus xylanisolvens sp. nov., a xylan-degrading bacterium from soil.

A xylan-degrading bacterium, strain X11-1(T), was isolated from soil collected in Nan province, Thailand. The strain was characterized based on its phenotypic and genotypic characteristics. Strain X11-1(T) was a Gram-stain-positive, facultatively anaerobic, spore-forming, rod-shaped bacterium. It contained meso-diaminopimelic acid in the cell-wall peptidoglycan. The major menaquinone was MK-7, anteiso-C(15 : 0) (56.6 %) and C(16 : 0) (14.0 %) were the predominant cellular fatty acids and diphosphatidylglycerol, phosphatidylmonomethylethanolamine, phosphatidylethanolamine and phosphatidylglycerol were the major phospholipids. The DNA G+C content was 51.6 mol%. Phylogenetic analysis using 16S rRNA gene sequences showed that strain X11-1(T) was affiliated to the genus Paenibacillus and was closely related to Paenibacillus naphthalenovorans KACC 11505(T) and Paenibacillus validus CCM 3894(T), with 96.5 % sequence similarity. Therefore, the strain represents a novel species of the genus Paenibacillus, for which the name Paenibacillus xylanisolvens sp. nov. is proposed. The type strain is X11-1(T) (=KCTC 13042(T) =PCU 311(T) =TISTR 1829(T)).
Assessing alcohol consumption: beverage-specific versus grouped-beverage questions.

OBJECTIVE The quantity-frequency method is commonly used to measure alcohol intake in large surveys. Because of time and space constraints, questionnaires are often shortened by combining questions on all types of alcohol into a single question. We investigated the effect of this practice using data from the Behavioral Risk Factor Surveillance System. METHOD We examined data collected from 213,842 respondents to surveys conducted by 32 states and the District of Columbia participating in the years 1987, 1988, 1989 and 1990. The 1987 and 1988 surveys asked questions about respondents' frequency and level of intake of specific alcohol-containing beverages. The 1989 and 1990 surveys asked about the frequency and quantity of intake of alcohol-containing beverages by combining all beverages into a single group. RESULTS Among drinkers, the mean number of drinks per month was higher for those who were asked beverage-specific questions than for those who were asked grouped-beverage questions (men: 37.0 vs 29.6; women: 17.0 vs 13.9). CONCLUSION Caution must be used in comparing level of alcohol intake from surveys in which beverages are not grouped identically.
EFFECT OF STORAGE CONDITIONS OF SPORES OF PENICILLIUM DIGITATUM ON ITS PARAMETERS OF GROWTH

espanolEl objetivo de este trabajo fue determinar el efecto el efecto de la temperatura (0 y -9°C) y tiempo (0, 7, 14 y 21 dias) de almacenamiento, sobre los parametros del crecimiento (tiempo de latencia y velocidad de crecimiento) de una suspension de esporas de Penicillium digitatum. Las condiciones experimentales fueron establecidas por un diseno factorial completo. El crecimiento fue realizado en agar dextrosa Sabouraud y el diametro de las colonias fue medido diariamente. Los parametros de crecimiento fueron calculados por el ajuste de las curvas del crecimiento con la ecuacion de Baranyi usando el programa DMFit. Los resultados demostraron que el tiempo de latencia inicialmente aumenta con la duracion del almacenamiento en baja temperatura y posteriormente disminuye conforme aumenta el tiempo de almacenamiento (p EnglishThe objective of this work was determine the effect of temperature (0 and -9°C) and time (0, 7, 14 and 21 days) of storage, on the parameters of growth, (lag time and growth rate) of one spore suspension of Penicillium digitatum. Experimental conditions were established by one factorial full design. The growth was realized in dextrose Sabouraud agar and the diameter of the colony was measured daily. The parameters of growth were calculated by fit of the growth curves with the Baranyi equation using the DMFit software. The results showed that the lag time first increased with the duration of storage in low temperature and then decreased as the duration of storage (p
10 years after NHANES I: mortality experience at initial followup, 1982-84.

The NHANES I Epidemiologic Followup Study (NHEFS) was initiated jointly by the National Center for Health Statistics and the National Institute on Aging in collaboration with other National Institutes of Health and Public Health Service agencies. The goal of NHEFS is to examine the relationship of baseline clinical, nutritional, and behavioral factors assessed in the first National Health and Nutrition Examination Survey (NHANES I-1971-75) to subsequent morbidity and mortality. Tracing for the initial followup began in 1981 and ended in 1984. This article compares the mortality experience of the NHEFS cohort with survival probabilities and cause-of-death distributions derived from U.S. vital statistics data. The analysis was done for 28 age-race-sex specific subgroups. The survival of each group of the NHEFS cohort corresponds quite closely to that expected on the basis of the U.S. life table survival probabilities. Mortality differentials by age, race, and sex are also quite similar between NHEFS and U.S. vital statistics. In addition, the cause-of-death distributions among NHEFS participants are quite similar to those expected based on national vital statistics. Thus, there do not seem to be any serious biases in the mortality data. The NHEFS, therefore, provides a unique resource for assessing the effects of baseline sociodemographic, health, and nutritional factors on future mortality in a large, heterogeneous sample that is representative of the nation's population.
Child survivorship estimation: methods and data analysis.

"The past 20 years have seen extensive elaboration, refinement, and application of the original Brass method for estimating infant and child mortality from child survivorship data. This experience has confirmed the overall usefulness of the methods beyond question, but it has also shown that.estimates must be analyzed in relation to other relevant information before useful conclusions about the level and trend of mortality can be drawn. This article aims to illustrate the importance of data analysis through a series of examples, including data for the Eastern Malaysian state of Sarawak, Mexico, Thailand, and Indonesia. Specific maneuvers include plotting completed parity distributions and 'time-plotting' mean numbers of children ever born from successive censuses. A substantive conclusion of general interest is that data for older women are not so widely defective as generally supposed. "
A-revolve: an adaptive memory-reduced procedure for calculating adjoints; with an application to computing adjoints of the instationary Navier–Stokes system

This article presents a low-storage and low-run-time approach for calculating numerical approximations of adjoint equations for the instationary Navier–Stokes equations with adaptive evaluation of the discretization step. It utilizes adaptive checkpointing. The amounts of memory reduction due to checkpointing and of the increase in run-time caused by repeated forward integration of the Navier–Stokes equations are reported. It is one result that memory reduction of two orders of magnitude only causes a slow down factor of 2–3 in run-time. It is a further result that the adaptive checkpointing for the instationary Navier–Stokes equations causes only a slight increase of the run-time compared to the static optimal checkpointing. The amounts of run-time increase caused by the adaptive checkpoint allocations compared with the static optimal checkpointing are reported as well.
An action of adrenaline on transmission in sympathetic ganglia, which may play a part in shock

We have had two reasons for approaching this problem. One of us [Burn, 1932] showed that when the hindleg of a dog was perfused with defibrinated blood through a cannula tied in the abdominal aorta 34 cm. above the bifurcation, the vasoconstriction produced by stimulating the lumbar sympathetic chain was very small. When adrenaline was added to the perfusing blood, however, the effect of the same stimulation was greater, and this augmentation outlasted the effect of the added adrenaline on the vascular tone. The observations were taken to mean that sympathetic stimulation was effected by the liberation of adrenaline from the post-ganglionic endings, and that in the preparation used the necessary store of this adrenaline was depleted, until it was restored by addition of adrenaline to the blood. Thus, the augmentation of the effect of sympathetic stimulation was thought to be due to a change at the post-ganglionic terminations. Recently, Dr P. Glees called our attention to a paper by Stohr [1939] in which large-scale drawings of sympathetic ganglia showed the ganglion cells surrounded by what St6hr described as chromaffine tissue. Dr Glees himself obtained phlotographs showing similar small cells. Reflexion suggested that if chromaffine celLs were present in sympathetic ganglia, they presumably exerted some function. What function could adrenaline have in sympathetic ganglia? The question recalled the observations which have just been described, in which the stimulation was applied to the preganglionic fibres of the sympathetic chain. It was clear that the augmentation of the effect of stimulation produced by adrenaline might have been due to a change in the ganglion whereby transmission was improved. Our second reason for studying this question was that we have recently [Biilbring & Burn, 1941] made observations on the transmission of impulses in the spinal cord, and have observed three effects of adrenaline. We found that adrenaline facilitated the action of small doses of acetylcholine in causing
De Statisticien à Data Scientist

Selon un rapport recent de la commission europeenne, le monde genere chaque minute 1,7 millions de milliards d'octets de donnees, soit l'equivalent de 360 000 DVD, et les entreprises qui bâtissent leur processus decisionnels en exploitant ces donnees accroissent leur productivite. Le traitement et la valorisation de donnees massives a des consequence en matiere d'emploi pour les diplomes des filieres statistiques. Quelles competences nouvelles les etudiants formes en statistique doivent-ils acquerir devenir des scientifiques des donnees ? Comment faire evoluer les formations pour permettre aux futurs diplomes de s'adapter aux evolutions rapides dans ce domaine, sans pour autant negliger les metiers traditionnels et le socle fondamental et perenne de la formation? Apres nous etre interroges sur la notion de donnees massives et l'emergence d'une "nouvelle" science : la science des donnees, nous presenterons les evolutions en cours dans la formation d'ingenieurs en Genie Mathematique et Modelisation a l'INSA de Toulouse.