Miracle-dz/UniFAR-FTUs huggingface dataset:
Ordonnancement en temps réel d'ateliers avec temps de préparation des ressources

Ce travail presente une methode et des outils pour l'ordonnancement en temps reel d'atelier lorsque des contraintes complexes issues du terrain sont a prendre en compte. L'approche retenue vise a caracteriser non pas une solution au probleme d'ordonnancement, mais un ensemble de solutions sous la forme de groupes d'operations permutables. Dans ce contexte, on considere un ensemble d'ordres de fabrication, chacun comportant une date de livraison et une date de debut au plus tot et etant compose d'un ensemble d'operations d'execution. Chaque operation d'execution necessite simultanement pour sa realisation un ensemble de ressources cumulatives ou disjonctives, chacune d'elles devant etre selectionnee dans un ensemble predefini appele pool. Les contraintes de precedence entre les operations d'execution d'un meme ordre de fabrication sont definies par des gammes non lineaires. On propose de caracteriser l'activite de preparation necessaire sur un sous-ensemble des ressources requises pour realiser une operation d'execution, par un enchainement de trois operations elementaires de preparation : le demontage, le changement de type et le montage. Chaque activite de preparation depend de la sequence des operations d'execution et chaque operation de preparation peut necessiter egalement des ressources complementaires. Un graphe potentiels-tâches particulier est utilise pour representer une sequence de groupes. Base sur une exploration de ce graphe, un algorithme polynomial d'insertion d'une operation dans un ordonnancement visant a minimiser la consequence de cette insertion sur les dates de livraison, est defini. Cet algorithme est utilise dans les methodes proposees pour generer une sequence de groupes initiale et pour l'amelioration de type tabou de cette sequence. Ces methodes sont validees sur des problemes classiques d'ordonnancement de projet et sur des problemes d'ordonnancement d' atelier avec preparation generes aleatoirement. Un systeme interactif d'aide a la decision est propose pour l'ordonnancement en temps reel d'un atelier avec preparation, base sur l'exploitation de la sequence de groupes. La nouvelle version du logiciel d'ordonnancement en temps reel ORDO basee sur ce travail est deja installee sur plusieurs sites industriels.
Quantifying layer similarity in multiplex networks: a systematic study

Computing layer similarities is an important way of characterizing multiplex networks because various static properties and dynamic processes depend on the relationships between layers. We provide a taxonomy and experimental evaluation of approaches to compare layers in multiplex networks. Our taxonomy includes, systematizes and extends existing approaches, and is complemented by a set of practical guidelines on how to apply them.
Rethinking Home Network Security

—The continued rise in the number of managed and unmanaged devices connected to home networks has expanded the threat surface in the home. We have seen increases in the number and impact of attacks targeting network and IoT devices in the home, yet effective mitigations targeting the home are still too few. Approaches have been proposed to holistically secure the home network, but such proposals also face a number of challenges in their practical uptake. More empirical research needs to be done to understand the context of use and needs of the stakeholders involved in securing home networks in order to rigorously evaluate and inform these solutions. As a step in this direction, we conduct a Grounded Theory exploration of context aimed at 1) understanding current security practice in the home to identify the areas that need improvement or support, and 2) identifying security-related practices in the home that could be leveraged to improve network security. We found evidence that current security practices in the home are focussed on securing endpoints; home users assess risk by evaluating the impact of a successful attack, and also the value of gain for the attacker; identiﬁcation of security problems in the home is done through visibility of harm, security alerts and warnings, and intuition; incident management in the home is mostly done through social networks and often undertaken by trusted individuals as an informal duty of care. We discuss these ﬁndings and provide recommendations for improving network security in the home.
The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit

Long PCR followed by nested PCR has previously been used to determine CYP2A6 160H alleles, but the method proved unreliable. We have optimized this approach in a DNA bank of 1032 subjects (age range 59–74 years) to give reliable results, yielding indirect molecular evidence and very strong statistical evidence of hitherto unrecognized common alleles (designated O) recalcitrant to the long PCR. Coding three alleles (160L, 160H and O) and an approach to association analysis originally developed to deal with null alleles implicit in ABO blood group phenotyping, the contribution of 160H (functionally null) to reduced smoking habit has been clearly measured for the first time, unconfounded by alleles null to the long PCR. The most significant findings (p < 0.01) are that the possession of a 160H allele, compared with not possessing a 160H allele, is associated with a mean age of starting regular smoking 3 years later (95% CI±1.93 years, average start age 20–21 years rather than 17–18 years); and that the average likelihood of quitting smoking at any time is 1.75 fold (95% CI. 1.17–2.61) for those possessing an 160H allele compared with those who have no 160H allele. This suggests that a smoking subject with a genotype predicted to confer 50% of the ability to eliminate nicotine via the CYP2A6 pathway has almost twice the likelihood of quitting smoking.
Motion monitoring and classification with center-biased motion estimation

A major problem in video surveillance is the robust detection of intrusive motion. A widespread technique is frame differencing, initiating an alarm procedure when the difference exceeds a predefined threshold. However, background motion and conflict motion are hard to distinguish. Full-search (FS) block-based motion estimation can be made more robust with respect to the rejection of very small motions, but it is still too sensitive and it has also the disadvantage of the high computational complexity. In our proposal we suggest to use a detection technique that is based on a new center-biased search technique and an original adaptive motion classification system. The proposed approach was validated via an implementation on a very long instruction word (VLIW) processor.
Comparison of RNA amplification methods and chip platforms for microarray analysis of samples processed by laser capture microdissection

Laser capture microdissection (LCM) permits isolation of pure cell populations from which RNA can be extracted, amplified, and subjected to microarray analysis, allowing information to be obtained on the gene expression profile of defined cell types. To avoid amplification artifacts and detect genes expressed at different levels, it is important to optimize the choice of both RNA amplification step and microarray platform. We captured by LCM the same colon cancer biopsy and conducted a cross comparison of distinct RNA amplification methods and different chip platforms. We tested two RNA amplification methods with different chemistry: the one‐cycle Ovation™ system (NuGEN) and the two‐cycle Ribo OA™ method (Arcturus). We also compared two different whole genome platforms, based on Affymetrix technology: the U133 plus 2.0 and the X3P array, with probe sets closer to the 3′ end of transcripts. After RNA amplification, microarray analysis, and data normalization, we investigated reproducibility and correlation of different methods and arrays. Our results indicate that the Arcturus Ribo OA method is superior for both array choices, especially in combination with X3P arrays, showing the lowest variance and Spearman correlation of 0.986. The quicker NuGEN procedure, when coupled with X3P arrays, also yielded excellent results (correlation of 0.951). These observations will be useful for planning large‐scale analyses of LCM‐dissected clinical samples. J. Cell. Biochem. 103: 556–563, 2008. © 2007 Wiley‐Liss, Inc.
A single phase grid integration scheme for battery-supercapacitor AC line hybrid storage system

A transformerless direct single phase grid-connected battery-supercapacitor hybrid energy storage system based on a modified boost inverter configuration and its associated control strategy are proposed in this paper. The proposed control strategy comprises a double loop output voltage controller, active and reactive power droop controller, battery state of charge (SOC) management system based on the extended Kalman filter (EKF) and supercapacitor voltage controller. Simulation results confirm that the proposed system is able to deliver or absorb the required active power and reactive power to or from the grid while allocating the ripple current to the supercapacitor. Furthermore, the system maintains the supercapacitor voltage at a pre-defined value while operating the battery inside a safe operating SOC range.
Reversible neurological syndromes with atypical pneumonia

Simultaneous or sequential involvement of lungs is frequently encountered with neurological syndromes like meningoencephalitis, cerebellitis, aseptic meningitis, transverse myelitis, or multiple cranial nerve palsies. However, pulmonary involvement is frequently overlooked when all the attention of physician is diverted to neurological disorder. Prompt and early recognition of such potentially treatable association is required to improve diagnostic and therapeutic outcome. We report six patients presenting with various neurological manifestations like meningitis, meningoencephalitis, and myelits associated with atypical pneumonia. With proper clinical correlation and relevant investigations, all of them were diagnosed in time and had remarkable recovery with appropriate treatment.
A quantitative reverse transcriptase polymerase chain reaction method for the detection of leukaemic cells with t(8;21) in peripheral blood

Abstract: We evaluated the usefulness of a recently developed real‐time reverse transcriptase polymerase chain reaction (RT‐PCR) system to detect minimal residual diseases (MRD) in patients with acute myelogenous leukaemia (AML) with chromosomal translocation t(8:21). The method was simple, rapid and reproducible for the quantity of chimeric AML1‐ETO (MTG8) transcripts. The ratio of the absolute copy number of a target gene (AML1‐ETO) to a control gene (glyceraldehyde‐3‐phosphate dehydrogenase, GAPDH) was calculated by using a fluorescence curve prepared from amplicons of serially diluted standard RNA. The relative points of MRD in bone marrow (BM) of 8 patients in the acute phase of the disease was from 0.85 to 3.0, whereas those of MRD in complete remission (CR) decreased to below 6.4×10−3. This method was also applied to evaluate chimeric transcripts in peripheral blood (PB) samples. The values in patients with t(8;21) AML were from 0.97 to 2.0 in the acute phase, whereas those in CR showed less than 2.2×10−4. There was 10−5‐fold difference in AML1‐ETO mRNA expression between PB samples in the acute phase and those in CR. The results suggest that we may easily monitor MRD in patients with t(8;21) AML through quantitative analysis of AML1‐ETO transcripts in blood samples.
Influence of Polysulphone-Derived Dialysis Membranes on the Interaction of Circulating Mononuclear Cells with the Endothelium

Purpose Cardiovascular morbidity in hemodialysis (HD) patients may be influenced by the activation of circulating mononuclear cells (MCs) with subsequently increased endothelium interaction. The use of more biocompatible membranes would reduce this monocyte activation. We compare monocyte activation after using two different high-flux polymers, polysulphone and polyethersulphone. Methods The first part of the study was done with 10 patients who successively received dialysis for 2 weeks with polysulphone and polyethersulphone. The second part with 30 patients dialyzed for 3 months with polysulphone or polyethersulphone. Blood samples were taken before (pre-HD) and after (post-HD) the first HD session with each membrane to evaluate the effect of a single HD session. To assess acute and chronic effects of membranes, blood samples were taken pre-HD, after 2 weeks (first part of study) and after 3 months (second part of study). MCs were isolated from blood and then incubated with cultured human endothelial cells to evaluate MC adhesion, MC-dependent endothelial toxicity, and endothelial protein expressions of nitric oxide synthase and endothelin-converting enzyme-1 (ECE-1). Results One single HD session did not induce any changes. Dialysis for 2 weeks (first part of study) with polyethersulphone reduced MC adhesion to endothelium, cellular toxicity, and ECE-1 protein expression compared to polysulphone or basal conditions. Dialysis for 3 months (second part of study) increased MC adhesion to endothelium, whereas cellular toxicity was decreased with both dialyzers compared to the basal situation. Conclusions Although polyethersulphone HD decreased the interaction of MC with the endothelium in short-term experiments, both membranes were comparable in the long-term.
IMPROVED PERFORMANCE OF HYBRID ELECTRIC VEHICLES WITH NOVEL REDUCED SWITCH MULTILEVEL QUASI

Hybrid electric vehicles (HEV) have attained a remarkable significance in automotive industry and continuous research is carried on optimisation of HEV. This paper attempts to enhance the performance of HEV by employing new stepped DC link coupled Quasi Z inverter. The proposed inverter aids efficient source management and offers simplified power conditioning circuitry for HEV. The hybrid topology ensures continuous operation of the drive for varied asymmetrical inputs and the self-boost nature lessens the source requirements. The mitigated harmonics with reduced stress on components, poses improved efficiency of 4.87% and reduction in torque ripple by 1% as compared to its predecessor fed to HEV. Simulated and experimental results using the designed prototype validate the proposed theoretical model. Furthermore, this paper analyses all the operating states of the proposed module and the performance of the integrated system is evaluated for various input conditions. Loss calculation and efficiency Assessment is performed to ascertain the advantages of the proposed inverter with HEVs.
EFFECT OF REAL EARNING MANAGEMENT ON COMPANY PERFORMANCE (EMPIRICAL STUDY ON GO PUBLIC COMPANIES INDEXED ON JII)

The purpose of this study is to determine the effect of real earning management on corporate performance on companies indexed in JII period 2013-2015. The research method used is explanatory which is designed to analyze earnings management practice for 3 years. The populations in this study are companies listed on the BEI in the Jakarta Islamic Index (JII) in 2013-2015. The technique of determining the sample in this study is purposive sampling. The data source used in this study is the annual financial statements published by publicly listed indexed companies in JII and published during the year 2013 to 2015. The results of the research with F test shows that together proxies real earning management that is cash flow operational, production cost and discretionary expense affect the performance of the company proxies with ROA. From the result of t test is known proxy production cost and discretionary expense have an effect on to company performance, while proxy Cash flow operational does not have an effect on to company performance. Keywords: Real Earning Management; CFO; PROD; DISCR; ROA
Determinants and impacts of marketing channel choice among cooperatives members: Evidence from agricultural cooperative in China

This paper examines the impact of agricultural cooperatives working as a marketing channel, and the determinant of members’ decision to sell products through agricultural based on household-level data of agricultural cooperatives members from poor rural areas in Sichuan province, in China. Employing different treatment effect estimators, i.e. PSM and IPWRA, we find that selling products through agricultural cooperatives has a positive and statistically significant effect on both farmers’ annual total household income and farm income. It was also found that the effect on farm income (around 180%) is higher than annual total household income (around 20%). Comparing the difference between ATTs and ATEs, we could suggest that the efficiency of agricultural cooperatives can be improved by encouraging non-sellers to sell products through agricultural cooperatives, which is possible to do according to the results of a probit model. Following empirical results obtained using the probit model, we conclude that farm size, farming machine, distance to market, credit constraint, sale condition, motivation to participate in agricultural cooperatives and the knowledge of agricultural cooperatives positively and significant influence the probability of a member selling products through agricultural cooperatives, while the market information ownership shows a negative significant effect on the choice.
Characterization of a Potent and Specific Class of Antisense Oligonucleotide Inhibitor of Human Protein Kinase C-α Expression*

The use of antisense oligonucleotides to inhibit the expression of targeted mRNA sequences is becoming increasingly commonplace. Although effective, the most widely used oligonucleotide modification (phosphorothioate) has some limitations. In previous studies we have described a 20-mer phosphorothioate oligodeoxynucleotide inhibitor of human protein kinase C-α expression. In an effort to identify improved antisense inhibitors of protein kinase C expression, a series of 2′ modifications have been incorporated into the protein kinase C-α targeting oligonucleotide, and the effects on oligonucleotide biophysical characteristics and pharmacology evaluated. The incorporation of 2′-O-(2-methoxy)ethyl chemistry resulted in a number of significant improvements in oligonucleotide characteristics. These include an increase in hybridization affinity toward a complementary RNA (1.5° C per modification) and an increase in resistance toward both 3′-exonuclease and intracellular nucleases. These improvements result in a substantial increase in oligonucleotide potency (>20-fold after 72 h). The most active compound identified was used to examine the role played by protein kinase C-α in mediating the phorbol ester-induced changes in c-fos, c-jun, and junB expression in A549 lung epithelial cells. Depletion of protein kinase C-α protein expression by this oligonucleotide lead to a reduction in c-jun expression but not c-fos orjunB. These results demonstrate that 2′-O-(2-methoxy)ethyl-modified antisense oligonucleotides are 1) effective inhibitors of protein kinase C-α expression, and 2) represent a class of antisense oligonucleotide which are much more effective inhibitors of gene expression than the widely used phosphorothioate antisense oligodeoxynucleotides.
Discordant and Nondiscordant Twins: Comparative Multimethod Risk Assessment in the Neonatal Period

Full-term neonate twins from weight-discordant pairs were compared with nondiscordant pairs on perinatal variables, minor physical anomalies, developmental status, and temperament/interactive measures. For perinatal variables, twins from the top quartile of discordance were found to be at higher risk than other twins. Both the total group of discordant twins and twins with the most extreme discordance had higher weighted minor physical anomaly scores, more minor physical anomalies, and lower developmental status scores than nondiscordant twins. For temperament, twins in the extreme discordant group were more active while awake than twins in the nondiscordant group. The results are discussed in relation to expected group differences in perinatal measures, the timing during gestation of insults related to discordance and minor physical anomalies, and the significance of behavioral differences between cotwins versus between groups. implications for developmental risk for both twins from discordant pairs are discussed.
MicroRNA: Dynamic Regulators of Macrophage Polarization and Plasticity

The ability of a healthy immune system to clear the plethora of antigens it encounters incessantly relies on the enormous plasticity displayed by the comprising cell types. Macrophages (MΦs) are crucial member of the mononuclear phagocyte system (MPS) that constantly patrol the peripheral tissues and are actively recruited to the sites of injury and infection. In tissues, infiltrating monocytes replenish MΦ. Under the guidance of the local micro-milieu, MΦ can be activated to acquire specialized functional phenotypes. Similar to T cells, functional polarization of macrophage phenotype viz., inflammatory (M1) and reparative (M2) is proposed. Equipped with diverse toll-like receptors (TLRs), these cells of the innate arm of immunity recognize and phagocytize antigens and secrete cytokines that activate the adaptive arm of the immune system and perform key roles in wound repair. Dysregulation of MΦ plasticity has been associated with various diseases and infection. MicroRNAs (miRNAs) have emerged as critical regulators of transcriptome output. Their importance in maintaining health, and their contribution toward disease, encompasses virtually all aspects of human biology. Our understanding of miRNA-mediated regulation of MΦ plasticity and polarization can be utilized to modulate functional phenotypes to counter their role in the pathogenesis of numerous disease, including cancer, autoimmunity, periodontitis, etc. Here, we provide an overview of current knowledge regarding the role of miRNA in shaping MΦ polarization and plasticity through targeting of various pathways and genes. Identification of miRNA biomarkers of diagnostic/prognostic value and their therapeutic potential by delivery of miRNA mimics or inhibitors to dynamically alter gene expression profiles in vivo is highlighted.