Miracle-dz/UniFAR-FTUs huggingface dataset:
Leveraging Binary Translation for Heterogeneous Profiling

Heterogeneous systems, such as those including a graphics processor for general computation, are becoming increasingly common. While this increases the potential computing power that can be leveraged, it also increases the complexity of the system. This in turn increases the complexity of understanding behavior of the system, which is important when developing new software as well as when designing a new heterogeneous platform. Most current approaches profile individual computational resources in isolation, making it difficult to understand the characteristics of the full system. In this paper, we present an approach based on binary instrumentation that simplifies the task of profiling the behavior of heterogeneous systems by enabling a user to easily combine profiling data from multiple resources. We accomplish this by using communication and computation functions as markers to align the profiles. By using a lightweight method, we can achieve an average overhead of 35% overall and only 1% overhead on the compute kernels.
Putative role for EPC‐1/PEDF in the G0 growth arrest of human diploid fibroblasts

EPC‐1/PEDF expression is closely associated with reversible growth arrest in normal human diploid fibroblast‐like (HDF) cells and is diminished with proliferative senescence in vitro. EPC‐1 expression in HDF cells is induced under conditions of density‐dependent contact inhibition and growth factor deprivation. Antiserum generated against EPC‐1 recognizes a secreted protein of approximately 50 kDa from medium conditioned by early passage HDF cells, but not from senescent cells. The addition of EPC‐1 antiserum to early population doubling level (PDL) cultures near the plateau phase of growth significantly increases the number of cells entering DNA synthesis. Affinity purified EPC‐1 antibodies alone enhance the ability of near plateau‐phase early PDL WI‐38 cells to synthesize DNA by as much as threefold. Further, the addition of recombinant EPC‐1 (rEPC‐1) to logarithmically growing cells resulted in a marked decrease in the ability of these cells to enter DNA synthesis. We also demonstrate the loss of EPC‐1 expression in WI‐38 and IMR‐90 HDF cell lines with both senescence and simian virus 40 (SV40) transformation. The loss of EPC‐1 expression with SV40 transformation occurs at the level of steady‐state mRNA and protein accumulation with genomic EPC‐1 sequences grossly intact. Taken together, these results suggest that EPC‐1 may play a role in the entry of early passage fibroblasts into a G0 state or the maintenance of such a state once reached. © 2003 Wiley‐Liss, Inc.
Genetic algorithm using independent component analysis in x-ray reflectivity curve fitting of periodic layer structures

A novel genetic algorithm (GA) utilizing independent component analysis (ICA) was developed for x-ray reflectivity (XRR) curve fitting. EFICA was used to reduce mutual information, or interparameter dependences, during the combinatorial phase. The performance of the new algorithm was studied by fitting trial XRR curves to target curves which were computed using realistic multilayer models. The median convergence properties of conventional GA, GA using principal component analysis and the novel GA were compared. GA using ICA was found to outperform the other methods with problems having 41 parameters or more to be fitted without additional XRR curve calculations. The computational complexity of the conventional methods was linear but the novel method had a quadratic computational complexity due to the applied ICA method which sets a practical limit for the dimensionality of the problem to be solved. However, the novel algorithm had the best capability to extend the fitting analysis based on Parratt's formalism to multiperiodic layer structures.
Changing Kidney Allocation Policy in France: the Value of Simulation

This paper advocates the value of simulation to promote changes in kidney allocation. Due to the scarcity of organs and to the competition between transplantation centers to obtain the best organs for their patients, any change in organ allocation policy remains a sensitive issue in public health decision-making. Organ allocation is not easily available for prospective experimental study. Observational stud-ies only support limited changes. A simulation tool in this context permits the comparison of observed results against simulated ones. In our experience in France, it has shown to be a helpful tool during the allocation design phase providing objective facts for the debates and increasing the potential for change.
Draft Genome Sequence of Kocuria rhizophila P7-4

ABSTRACT We report the draft genome sequence of Kocuria rhizophila P7-4, which was isolated from the intestine of Siganus doliatus caught in the Pacific Ocean. The 2.83-Mb genome sequence consists of 75 large contigs (>100 bp in size) and contains 2,462 predicted protein-coding genes.
Expression of Vascular Endothelial Growth Factor in Human Umbilical Vein Endothelial Cells Stimulated with Interleukin-1α

Summary Vascular endothelial growth factor (VEGF) is a specific mitogen for endothelial cells. We studied the production of VEGF by human umbilical vein endothelial cells (HUVEC) and smooth muscle cells (SMC) in response to the stimulation with interleukin-1α (IL-1α). HUVEC expressed VEGF mRNA in response to IL-1α in doseand time-dependent manners. In HUVEC VEGF protein was detected only in cell lysates whereas in SMC most of the VEGF protein was detected in the conditioned medium. Immunofluorescent staining also confirmed the cell-associated VEGF in HUVEC. IL-1α also induced the expression of mRNA for IL-1α itself in HUVEC. Cycloheximide treatment of HUVEC slightly inhibited the IL-1α-induced expression of VEGF mRNA, and IL-1α may mediate, at least in part, VEGF expression in response to IL-1α. The growth of HUVEC stimulated with IL-1α was inhibited by a neutralizing antibody against VEGF. We conclude that IL-1α and VEGF may play an important role in autocrine growth regulation of HUVEC.
Obscured and Unobscured Active Galactic Nuclei in the Spitzer Space Telescope First Look Survey

Selection of active galactic nuclei (AGNs) in the infrared facilitates the discovery of AGNs whose optical emission is extinguished by dust. In this paper, we use the Spitzer Space Telescope First Look Survey (FLS) to assess the fraction of AGNs with mid-infrared (MIR) luminosities that are comparable to quasars and that are missed in optical quasar surveys because of dust obscuration. We begin by using the Sloan Digital Sky Survey (SDSS) database to identify 54 quasars within the 4 deg2 extragalactic FLS. These quasars occupy a distinct region in MIR color space by virtue of their strong, red continua. This has allowed us to define an MIR color criterion for selecting AGN candidates. About 2000 FLS objects have colors that are consistent with them being AGNs, but most are much fainter in the MIR than the SDSS quasars, which typically have 8 μm flux densities S8.0 ∼ 1 mJy. We have investigated the properties of 43 objects with S8.0 ≥ 1 mJy that satisfy our AGN color selection. This sample should contain both unobscured quasars as well as AGNs that are absent from the SDSS survey because of extinction in the optical. After removing 16 known quasars, three probable normal quasars, and eight spurious or confused objects from the initial sample of 43, we are left with 16 objects that are likely to be obscured quasars or luminous Seyfert 2 galaxies. This suggests that the numbers of obscured and unobscured AGNs are similar in samples selected in the MIR at S8.0 ∼ 1 mJy.
Applying Mobile and Pervasive Computer Technology to Enhance Coordination of Work in a Surgical Ward

Collaboration, coordination, and communication are crucial in maintaining an efficient and smooth flow of work in an operating ward. This coordination, however, often comes at a high price in terms of unsuccessfully trying to get hold of people, disturbing telephone calls, looking for people, and unnecessary stress. To accommodate this situation and to increase the quality of work in operating wards, we have designed a set of pervasive computer systems which supports what we call context-mediated communication and awareness. These systems use large interactive displays, video streaming from key locations, tracking systems, and mobile devices to support social awareness and different types of communication modalities relevant to the current context. In this paper we report qualitative data from a one-year deployment of the system in a local hospital. Overall, this study shows that 75% of the participants strongly agreed that these systems had made their work easier.
Creativity in Three Samples of Photographers: A Validation of the Adjective Check List Creativity Scale

The creativity of photographers was investigated in three samples: photography students (n = 17), neophyte photographers (n = 46), and experienced photographers (n = 49). All participants completed the Adjective Check List (ACL), scored for Domino's creativity (Cr) scale; these scores were correlated with various indexes of creativity, including self- and peer-ratings, ratings of portfolios, and course grades. The findings support the validity of the ACL Cr scale as a measure of creativity.
A Four Dimension Graph Model for Automatic Text Summarization

Text summarization is the process of automatically creating a shorter version of one or more text documents. In this context, word-based, sentence-based and graph-based methods approaches are largely used. Among these, graph based methods for automatic text summarization produce summaries based on the relationships between sentences. These relationships may also support the creation of several text processing applications such as extractive and abstractive summaries, question-answering and information retrieval systems, among others. A new graph model for text processing applications is proposed in this paper. It relies on four dimensions (similarity, semantic similarity, co reference, discourse information) to create the graph. The rationale behind the proposal presented here is resorting to more dimensions than previous works, and taking into account co reference resolution, taking into account to the role of pronouns in connecting the sentences. Co reference was not used in any previous graph based summarization technique. An experiment was performed using the Text Rank algorithm with the presented approach, on the CNN corpus. The results show that the model proposed here outperforms the current approaches both quantitatively and qualitatively.
MSM2013 IE Challenge: Annotowatch

In this paper, we describe our approach taken in the MSM2013 IE Challenge, which was aimed at concept extraction from microposts. The goal of the approach was to combine several existing NER tools which use different classification methods and benefit from their combination. Several NER tools have been chosen and individually evaluated on the challenge training set. We observed that some of these tools performed better on different entity types than other tools. In addition, different tools produced diverse results which brought a higher recall when combined than that of the best individual tool. As expected, the precision significantly decreased. The main challenge was in combining annotations extracted by diverse tools. Our approach was to exploit machine-learning methods. We have constructed feature vectors from the annotations yielded by different extraction tools and various text characteristics, and we have used several supervised classifiers to train the classification models. The results showed that several classification models have achieved better results than the best individual extractor.
Study on soft phase locked method to solving the synchronization problem of active power filter in stand-alone power grid

Traditional LC filters can't work stably in small rating stand-alone power grid. So active power filter (APF) is becoming an important tool to solve the power quality problem in small rating stand-alone power grid. In most current detection algorithm of APF, it needs a synchronizing signal. Firstly, the influence of the synchronizing signal error on current detection of APF is analyzed in this paper. Voltage distortion, voltage unbalance and frequency fluctuation are frequent and severe in small rating stand-alone power grids, so traditional synchronizing signal obtaining method--phase locking based on zero-cross detection can't work effectively in small rating stand-alone power grid. Then a soft phase locked loop with additional filter is proposed. It can lock the phase angle on to the positive sequence of fundamental voltage accurately and rapidly. It ensures the performance of APF applied in the small rating stand-alone power grid. Moreover, the soft phase locked loop is easy to be implemented in a Digital Signal Processor (DSP). Simulation and experimental results validate that the soft phase locked loop has satisfactory performance.
Positive emotional arousal has no effect on speeding intention

The Theory of Planned Behaviour (TPB) has been used successfully in the investigation of driver behaviour. However the theory has been criticised for not accounting for emotion and this deficiency may be responsible for unaccounted for variance in behavioural intention. Prior research has suggested that speeding behaviour has an emotional component. The aim of this research was to extend the TPB by incorporating a measure of emotional arousal which was based on an intention to exceed the speed limit by more than 20 km/ph. A convenience sample of 176 drivers (43 per cent male; 57 per cent female) aged between 18 and 61 years (53 per cent aged less than 25 years; 47 per cent over 26 years) was recruited. An online questionnaire was developed based on the TPB and included measures of arousal based on Bradley and Lang (1999), and a measure of past speeding behaviour. Questionnaires were completed anonymously with respondents being directed through social networking sites to the questionnaire web link. The traditional TPB model accounted for 53.2 per cent of variance in speeding intention, with past behaviour increasing this by 6.5 per cent, and arousal accounting for an additional 0.01 per cent. Past behaviour, attitude, and perceived behavioural control were the most influential predictors of intention. There appears to be considerable challenges in finding an appropriate measurement of emotion for inclusion in TPB research for speeding intention. However the TPB variables (including past behaviour) accounted for a good proportion of the variance in intention.
The connection of observed hostile family conflict to adolescents' developing autonomy and relatedness with parents

Abstract This study examined the link between hostile conflict in families with adolescents and adolescents' efforts to establish autonomy and relatedness in interactions with parents in both normal and psychiatrically impaired groups. Longitudinal, observational data were obtained by coding family interaction tasks involving 53 adolescents and their two parents at age 14 and age 16 years. Measures were obtained for hostile adolescent-parent conflict, hostile marital conflict, and indices of adolescents' success or difficultly in establishing autonomy and relatedness in interactions with parents. Relative increases in adolescent-parent hostile conflict from age 14 to 16 years were predicted by adolescents' behaviors actively undermining autonomy in disagreements with parents at age 14 years. Hostile marital conflict observed by the adolescent at age 14 years predicted adolescent withdrawal from the hostile parent over time, a prediction that was not mediated by observed parenting behaviors. Difficulties in establishing autonomy and relatedness were linked to prior history of psychiatric difficulty. A developmental view of conflict as both reflecting and predicting difficulties in adolescents' establishing autonomy and relatedness in interactions with parents is proposed.
Change of thermal stability of colicin E7 triggered by acidic pH suggests the existence of unfolded intermediate during the membrane‐translocation phase

Purified colicin E7 was analyzed by CD spectrum and gel filtration chromatography in a mimicking membrane‐translocation phase. It was found that the CD spectra of colicin E7 at pH 7 and pH 2.5 were similar. Although the melting temperature of the protein shifted from 54.5°C to 34°C at low pH, the thermal denaturation curves of colicin E7 at different pH conditions still fit a two‐state model. These experimental results imply that a minor structural change, triggered by acidic pH, for instance, may reduce the energy required for protein melting. In contrast to the minor change in secondary structure at different pH conditions, we observed that, in vitro, all monomeric colicin E7s converted into multimer‐like conformations after recovering from the partial unfolding process. This multimeric form of colicin can only be dissociated by formamide and guanidine hydrochloride, indicating that this protein complex is indeed formed by aggregation of the monomeric colicins. Most interestingly, the aggregated colicins still perform in vivo bacteriocidal activity. We suggest that in a partial unfolding state the colicin is prepared for binding to the specific targets for translocation through the membrane. However, in the absence of specific targets in vitro these unfold intermediates may therefore aggregate into the multimeric form of colicins. Proteins 32:17–25, 1998. © 1998 Wiley‐Liss, Inc.
Automagically Encoding Adverse Drug Reactions in MedDRA

Pharmacovigilance is the field of science devoted to the collection, analysis, and prevention of Adverse Drug Reactions (ADRs). Efficient strategies for the extraction of information about ADRs from free text sources are essential to support the important task of detecting and classifying unexpected pathologies, possibly related to (therapy-related) drug use. Narrative ADR descriptions may be collected in different ways, e.g., Either by monitoring social networks or through the so called "spontaneous reporting, the main method pharmacovigilance adopts in order to identify ADRs. The encoding of free-text ADR descriptions according to MedDRA standard terminology is central for report analysis. It is a complex work, which has to be manually implemented by the pharmacovigilance experts. The manual encoding is expensive (in terms of time). Moreover, a problem about the accuracy of the encoding may occur, since the number of reports is growing up day by day. In this paper, we propose Magi Coder, an efficient Natural Language Processing algorithm able to automatically derive MedDRA terminologies from free text ADR descriptions. Magi Coder is part of Vigi Work, a web application for online ADR reporting and analysis. From a practical point of view, Magi Coder reduces the encoding time of ADR reports. Pharmacologists have simply to review and validate the MedDRA terms proposed by Magi Coder, instead of choosing the right terms among the 70K terms of MedDRA. Such improvement in the efficiency of pharmacologists' work has a relevant impact also on the quality of the following data analysis. Our proposal is based on a general approach, not depending on the considered language. Indeed, we developed Magi Coder for the Italian pharmacovigilance language, but preliminarily analyses show that it is robust to language and dictionary changes.
Online Behavior Identification in Distributed Systems

The diagnosis, prediction, and understanding of unexpected behavior is crucial for long running, large scale distributed systems. However, existing works focus on the identification of faults in specific time moments preceded by significantly abnormal metric readings, or require a previous analysis of historical failure data. In this work, we propose an online behavior classification system to identify a wide range of undesired behaviors, which may appear even in healthy systems, and their evolution over time. We employ a two-step process involving two online classifiers on periodically collected system metrics to identify at runtime normal and anomalous behaviors such as deadlock, starvation and livelock, without any previous analysis of historical failure data. Our approach achieves over 80% accuracy in detecting unexpected behaviors and over 90% accuracy in identifying their type with a short delay after the anomalies appear, and with minimal expert intervention. Our experimental analysis uses system execution traces obtained from a Google cluster and from our in-house distributed system with varied behaviors, and shows the benefits of our approach as well as future research challenges.
Mitochondrial DNA and phylogeography of the grasshopper Trimerotropis pallidipennis in relation to clinal distribution of chromosome polymorphisms

Trimerotropis pallidipennis is an American grasshopper whose South American populations are polymorphic for pericentric inversions. Colonization of southern latitudes was by North American grasshoppers with basic chromosome arrangements, presumably along the Andean dry lands of South America. In Argentina, the frequencies of some of the rearrangements are correlated with geographical and climatic variables, following similar patterns among different ecological gradients, and are probably maintained by geographically variable coefficients of selection. Restriction site variation of mitochondrial DNA is used as a tool for determining the species history in relation to the formation of clines. Populations located along an altitudinal gradient, and others outside the cline, are analysed through phylogeographical studies. There is no strong geographical orientation in the unrooted tree connecting all 17 mitochondrial DNA haplotypes found. Many of them are present in most of the populations analysed, indicating high gene flow. The fact that there is no obvious differentiation in haplotype distribution between both extremes of the cline nor between chromosomally differentiated populations shows that the cline is not the result of a hybrid zone and reinforces the selection hypothesis. The estimation of the overall nucleotide divergence between the hypothetical ancestral haplotype and the other molecules shows that T. pallidipennis haplotypes started diverging from each other about 3 Myr ago. This result is in agreement with the time when the Isthmus of Panamá rose (2–3 Myr ago), probably favouring the migration of many species between both hemispheres.
Validation of malingered amnesia measures with a large clinical sample

A large sample of chronic postconcussive patients with and without overt malingering signs was compared with objectively brain-injured patients on common episodic memory and malingered amnesia measures. Probable malingerers and traumatically brain-injured subjects were not differentiated on popular episodic recall tests. In contrast, probable malingerers performed poorly on the Rey 15-Item, Rey Word Recognition List, Reliable Digit Span, Portland Digit Recognition Test, and Rey Auditory Verbal Learning Test recognition trial. These findings validated both commonly cited malingering measures and newly introduced methods of classifying malingering in real-world clinical samples. The base rate for malingering in chronically complaining mild head injury patients may be much larger than previously assumed.