Miracle-dz/UniFAR-FTUs huggingface dataset:
In defence of infant observational research

This article is a reply to Steven Groarke’s ‘Psychoanalytical infant observation: a critical assessment’ which was published in this journal (10:4, 299–321, December 2008). Psychoanalytic infant observation is a method which was initiated at the Tavistock Clinic over 50 years ago. It has long been practiced there as a key element in the education and training of child psychotherapists, social workers and other professional workers (Trowell, Paton, Davids, & Miles, 1998) and has been taken up in many other institutions and countries. Infant observation takes the form of a weekly observation of an hour or so, taking place optimally over a 2-year period, of a baby and its caregivers (usually mainly mothers) from the time of birth onwards, in the infant’s normal home setting. Observations are recorded from memory in written notes, which are then discussed by a supervisor and observers of other infants, in a weekly seminar. Steven Groarke argues that the use of psychoanalytic infant observation as a form of research is a misleading and potentially harmful diversion from its primary educational purpose. He contends that parallels which have been suggested between the psychoanalytic clinical situation, and that of infant observation, are misguided. For example, the phenomena of transference and counter-transference which have a central place in psychoanalytic practice have, in his view, little relevance to infant observation, since their heuristic value depends on clinical interpretations which are precluded in the observational setting. He suggests that my interest in infant observation research may be motivated mainly by a political concern to defend the scientific credibility of psychoanalysis. As my work on the potential value of psychoanalytic infant observation as a research method is a major focus of criticism in Groarke’s article, I am taking this opportunity to respond to his arguments. The questions which he seeks to explore are certainly significant ones, on which those interested in psychoanalytic infant observation may wish to reflect.
RouteBoxer library for Google Android platform

Several Android applications such as Google Maps provides map-based location information, directions, and turn-byturn navigation to assists user while driving. The RouteBoxer algorithm to identify areas along particular route is mostly implemented as web based application whereas it quite needed in several mobile applications. This research implements the RouteBoxer algorithm as a library based on Google Maps Android API on Google Android platform using Android Studio. The compiled library file or the library project source code can be imported into an Android application project as an Android application project module. This is research also describes on how the algorithm would perform based on the amount of data provided and the results show that the RouteBoxer algorithm has exponential growth rate.
mpMoRFsDB: a database of molecular recognition features in membrane proteins

SUMMARY Molecular recognition features (MoRFs) are small, intrinsically disordered regions in proteins that undergo a disorder-to-order transition on binding to their partners. MoRFs are involved in protein-protein interactions and may function as the initial step in molecular recognition. The aim of this work was to collect, organize and store all membrane proteins that contain MoRFs. Membrane proteins constitute ∼30% of fully sequenced proteomes and are responsible for a wide variety of cellular functions. MoRFs were classified according to their secondary structure, after interacting with their partners. We identified MoRFs in transmembrane and peripheral membrane proteins. The position of transmembrane protein MoRFs was determined in relation to a protein's topology. All information was stored in a publicly available mySQL database with a user-friendly web interface. A Jmol applet is integrated for visualization of the structures. mpMoRFsDB provides valuable information related to disorder-based protein-protein interactions in membrane proteins. AVAILABILITY http://bioinformatics.biol.uoa.gr/mpMoRFsDB
Managing multiple collections, multiple languages, and multiple media in a distributed digital library

Managing the organizational and software complexity of a comprehensive digital library presents a significant challenge. Different library collections each have their own distinctive features. Different presentation languages have structural implications such as left-to-right writing order and text-only interfaces for the visually impaired. Different media involve different file formats, and—more importantly—radically different search strategies are required for non-textual media. In a distributed library, new collections can appear asynchronously on servers in different parts of the world. And as searching interfaces mature from the command-line era exemplified by current Web search engines into the age of reactive visual interfaces, experimental new interfaces must be developed, supported, and tested. This paper describes our experience, gained from operating a substantial digital library service over several years, in solving these problems by designing an appropriate software architecture.
A Natural Deduction style proof system for propositional μ-calculus and its formalization in inductive type theories

In this paper, we present a formalization of Kozen's propositional modal $\mu$-calculus, in the Calculus of Inductive Constructions. We address several problematic issues, such as the use of higher-order abstract syntax in inductive sets in presence of recursive constructors, the encoding of modal (``proof'') rules and of context sensitive grammars. The encoding can be used in the \Coq system, providing an experimental computer-aided proof environment for the interactive development of error-free proofs in the $\mu$-calculus. The techniques we adopted can be readily ported to other languages and proof systems featuring similar problematic issues.
Who's talking: drawing conclusions from focus groups—some methodological considerations

The central argument of this article is that participants in focus groups may talk and interact in many capacities. As a consequence a central methodological question in analysing focus group material is who's talking—that is, in what way are the utterances of individual members of the focus group to be interpreted. This problem is discussed by using material from three focus groups discussing the phenomenon ‘burnout’. We suggest that the participants of focus groups may constitute themselves in various ways, even just as an array of individuals talking together, without being a group and that they may shift between these different modes of interacting. Two interactive problems seem to be particularly important in the establishment of a focus group. A first interactive problem for the participants is to establish a common ground; a second is to add their contributions to the common ground. This has implications in the way the researcher is able to attribute attitudes and opinions to persons in focus groups.
Attenuation of Acute and Chronic Restraint Stress-induced Perturbations in Experimental Animals by Nelumbo nucifera Gaertn

Aqueous extract of leaves of Nelumbo nucifera was investigated on acute stress (immobilization stress)-induced biochemical alterations in Swiss mice. The animals were also subjected to acute physical stress (swimming endurance test) and acute chemical stress (writhing test) to gauge the antistress potential of the extract. Further to evaluate the antistress activity of Nelumbo nucifera in chronic stress condition, fresh Wistar rats were subjected to cold restraint stress (4° for 1 h) for 7 days after 21 days of pretreatment with the extract. Stimulation of hypothalamus pituitary adrenal axis in stressful condition alters plasma glucose, triglyceride, cholesterol, total protein and corticosterone levels. Pretreatment with the extract significantly ameliorated the stress-induced variations in these biochemical levels in both acute and chronic stress models. The extract treated animals showed increase in swimming endurance time and reduced number of writhes in physical and chemical-induced stress models respectively. Treatment groups also reverted back perturbed neurotransmitter levels (norepinephrine, dopamine and 5-hydroxytryptamine) in brain as well as increase in adrenal gland weights and atrophy of spleen caused by cold chronic stress. In mice immunized with sheep red blood cells, treatment groups subjected to restraint stress prevented the humoral immune response to the antigen. Histopathological studies of adrenal gland of stress control group revealed vacuolar degeneration, loss of architecture and formation of lesions in the cortex, which was reversed by extract treatment. The results indicate that aqueous extract of Nelumbo nucifera has significant adaptogenic activity against a variety of biochemical, histological, physiological and immunological perturbations in acute and chronic stress models.
The Function of Mass Media Agenda Setting

This study, a statewide follow-up to the original 1968 Chapel Hill, N.C. , agenda-setting study published in 1972 in Public Opinion Quarterly, used poll and content analysis data to compare media use and agenda agreement for different types of reference groups: men vs. women, non-whites vs. whites, young vs. old, higher- vs. lower-formally educated and rich vs. poor. When individuals increase their newspaper reading, then agreement on important public issues within the gender, racial and age groups to which they belong increases to a point of near consensus. Those of higher vs. lower education also come close to sharing issues, although the sharing is less dramatic between rich and poor. Increased television news viewing also results in higher reference group consensus on key public issues. The study concludes: one major function of mass media is to enhance group consensus within the larger social system by providing issue agenda options more attractive than just those historically learned and expressed as an aspect of one's gender, race, age, level of education, or — to a lesser extent — level of wealth. Media public issue agendas compete with unique historical agendas of readers/viewers and often win, to the benefit of the social system if the system can agree on workable solutions to the important problems.
Competing Mechanisms of Gamma and Beta Oscillations in the Olfactory Bulb Based on Multimodal Inhibition of Mitral Cells Over a Respiratory Cycle123

Visual Abstract Gamma (∼40-90 Hz) and beta (∼15-40 Hz) oscillations and their associated neuronal assemblies are key features of neuronal sensory processing. However, the mechanisms involved in either their interaction and/or the switch between these different regimes in most sensory systems remain misunderstood. Gamma (∼40-90 Hz) and beta (∼15-40 Hz) oscillations and their associated neuronal assemblies are key features of neuronal sensory processing. However, the mechanisms involved in either their interaction and/or the switch between these different regimes in most sensory systems remain misunderstood. Based on in vivo recordings and biophysical modeling of the mammalian olfactory bulb (OB), we propose a general scheme where OB internal dynamics can sustain two distinct dynamic states, each dominated by either a gamma or a beta regime. The occurrence of each regime depends on the excitability level of granule cells, the main OB interneurons. Using this model framework, we demonstrate how the balance between sensory and centrifugal input can control the switch between the two oscillatory dynamic states. In parallel, we experimentally observed that sensory and centrifugal inputs to the rat OB could both be modulated by the respiration of the animal (2-12 Hz) and each one phase shifted with the other. Implementing this phase shift in our model resulted in the appearance of the alternation between gamma and beta rhythms within a single respiratory cycle, as in our experimental results under urethane anesthesia. Our theoretical framework can also account for the oscillatory frequency response, depending on the odor intensity, the odor valence, and the animal sniffing strategy observed under various conditions including animal freely-moving. Importantly, the results of the present model can form a basis to understand how fast rhythms could be controlled by the slower sensory and centrifugal modulations linked to the respiration. Visual Abstract: See Abstract
Activation of silent mating type information regulation 2 homolog 1 by human chorionic gonadotropin exerts a therapeutic effect on hepatic injury and inflammation

Incidence and prevalence of inflammatory liver diseases has increased over the last years, but therapeutic options are limited. Pregnancy induces a state of immune tolerance, which can result in spontaneous improvement of clinical symptoms of certain autoimmune diseases including autoimmune hepatitis (AIH). We investigated the immune‐suppressive mechanisms of the human pregnancy hormone, chorionic gonadotropin (hCG), in the liver. hCG signaling activates silent mating type information regulation 2 homolog 1 (SIRT1), which deacetylates forkhead box o3 (FOXO3a), leading to repression of proapoptotic gene expression, because the immunosuppressive consequence attributed to the absence of caspase‐3 activity of hepatocellular interleukin 16 (IL‐16) is no longer processed and released. Thus, serum levels of IL‐16, a key chemotactic factor for CD4+ lymphocytes, were reduced and migration to injured hepatocytes prevented. Furthermore, elevated IL‐16 levels are found in the sera from patients with AIH, hepatitis B virus, hepatitis C virus, and nonalcoholic steatohepatitis. Conclusion: Here, we report that hCG regulates the SIRT1/FOXO3a axis in hepatocytes, resulting in immune suppression by attenuating caspase‐3–dependent IL‐16 processing and release, which concomitantly prevents autoaggressive T‐cell infiltration of the liver. Considering the low toxicity profile of hCG in humans, interrupting the inflammatory cycle by hCG opens new perspectives for therapeutic intervention of inflammatory liver diseases. (Hepatology 2017;65:2074‐2089).
Decision Making, Self-Efficacy, and the Place of Career Education in Elementary School Social Studies

I n 1960, Shirley Engle identified the primary purposes or "heart of social studies instruction" as educating citizens living in a democracy and teaching them the process of decision making based on values formulation through genuine problem solving. Subsequent research underscored the construct that effective social studies education must emphasize an understanding of democratic principles and social justice through meaningful student engagement that is relevant to students' sociocultural context. Engle and Ochoa advocated that teachers give students guided practice in identifying the techniques of observation, open inquiry, critical thinking, problem solving, values formulation, and intellectual justification to empower all students to become active participants, mindful of the many controversial and complex issues that they encounter each day. That suggested structure supports the framework established by the National Council for the Social Studies (NCSS). In 1992, NCSS adopted a program whose primary purpose is "to help
Contrôle des évolutions d'un système d'information pour la recherche clinique

In order to face evolutions of software systems, model-driven engineering (MDE) uses model transformations for software development. This paper focuses on issues that are essential in the context of information systems that process data from clinical trials. Indeed, such software systems should adapt to recurrent evolutions of their contexts. This way, by defining model structures and model components behaviours, definition of extension points allows to describe model evolutions, and thus makes it possible to manage them. In this paper we propose to define a framework for applied models transformations in order to master evolution requirements of an information retrieval system. MOTS-CLÉS : ingénierie dirigée par les modèles, évolution, système d’information scientifique.
Phoneme-Discriminative Features for Dysarthric Speech Conversion

We present in this paper a Voice Conversion (VC) method for a person with dysarthria resulting from athetoid cerebral palsy. VC is being widely researched in the field of speech processing because of increased interest in using such processing in applications such as personalized Text-To-Speech systems. A Gaussian Mixture Model (GMM)-based VC method has been widely researched and Partial Least Square (PLS)-based VC has been proposed to prevent the over-fitting problems associated with the GMM-based VC method. In this paper, we present phoneme-discriminative features, which are associated with PLS-based VC. Conventional VC methods do not consider the phonetic structure of spectral features although phonetic structures are important for speech analysis. Especially for dysarthric speech, their phonetic structures are difficult to discriminate and discriminative learning will improve the conversion accuracy. This paper employs discriminative manifold learning. Spectral features are projected into a subspace in which a near point with the same phoneme label is close to another and a near point with a different phoneme label is apart. Our proposed method was evaluated on dysarthric speaker conversion task which converts dysarthric voice into non-dysarthric speech.
An E-Supervision Model

In this article, the authors describe the implementation and use of two-way interactive videoconferencing for supervising student clinicians. They provide a rationale for and describe the e-supervision model as it has been implemented within a public school setting. A description of the technical and equipment needs is included for individuals interested in implementing a similar program. The authors also discuss the identified strengths and weakness of the model and implications for clinical training. This information may be of interest to professionals engaged in supervision and members of graduate training programs, especially persons who are developing a distance learning component.
Radiofrequency Ablation Combined with Transcatheter Arterial Chemoembolization for the Treatment of Single Hepatocellular Carcinoma of 2 to 5 cm in Diameter: Comparison with Surgical Resection

Objective To compare the effectiveness of radiofrequency ablation (RFA) combined with transcatheter arterial chemoembolization (TACE) with surgical resection in patients with a single hepatocellular carcinoma (HCC) ranging from 2 to 5 cm. Materials and Methods The study participants were enrolled over a period of 29 months and were comprised of 37 patients in a combined therapy group and 47 patients in a surgical resection group. RFA was performed the day after TACE, and surgical resection was performed by open laparotomy. The two groups were compared with respect to the length of hospital stay, rates of major complication, and rates of recurrence-free and overall survival. Results Major complications occurred more frequently in the surgical resection group (14.9%) than in the combined therapy group (2.7%). However, there was no statistical significance (p = 0.059). The rates of recurrence-free survival at 1, 2, 3 and 4 years were similar between the combined therapy group (89.2%, 75.2%, 69.4% and 69.4%, respectively) and the surgical resection group (81.8%, 68.5%, 68.5% and 65%, respectively) (p = 0.7962, log-rank test). The overall survival rates at 1, 2, 3 and 4 years were also similar between groups (97.3%, 86.5%, 78.4% and 78.4%, respectively, in the combined therapy group, and 95.7%, 89.4%, 84.3% and 80.3%, respectively, in the surgical resection group) (p = 0.6321, log-rank test). Conclusion When compared with surgical resection for the treatment of a single HCC ranging from 2 to 5 cm, RFA combined with TACE shows similar results in terms of recurrence-free and overall survival rates.
Improved Perfusion and Tracer Kinetic Imaging Using Parallel Imaging

Dynamic contrast enhanced MRI is a valuable method to get functional information of the microvessel system. This article will describe the improvement in perfusion and tracer kinetic imaging by using parallel imaging techniques. The basic principles of kinetic analysis, the contrast mechanisms used and the scan techniques applied are addressed to give a better understanding of the influence of parallel imaging on dynamic contrast enhanced MRI. The effect of different parallel imaging techniques on scan efficiency and scan planning is part of the discussion. From the clinical applications shown, it can be concluded that parallel imaging is a very important contribution for improved dynamic contrast enhanced imaging.
Personalized Recommendation Based on Evolutionary Multi-Objective Optimization [Research Frontier]

Traditional recommendation techniques in recommender systems mainly focus on improving recommendation accuracy. However, personalized recommendation, which considers the multiple needs of users and can make both accurate and diverse recommendations, is more suitable for modern recommender systems. In this paper, the task of personalized recommendation is modeled as a multi-objective optimization problem. A multiobjective recommendation model is proposed. The proposed model maximizes two conflicting performance metrics termed as accuracy and diversity. The accuracy is evaluated by the probabilistic spreading method, while the diversity is measured by recommendation coverage. The proposed MOEA-based recommendation method can simultaneously provide multiple recommendations for multiple users in only one run. Our experimental results demonstrate the effectiveness of the proposed algorithm. Comparison experiments also indicate that the proposed algorithm can make more diverse yet accurate recommendations.
Mayo's older americans normative studies: Updated AVLT norms for ages 56 to 97

Abstract Data obtained in Mayo's Older Americans Normative Studies (MOANS) provide age-specific norms for Rey's Auditory-Verbal Learning Test (AVLT) on a sample of 530 cognitively normal persons age 56 to 97. The information reported here updates and revises our previously published AVLT norms for the elderly. In addition to expanding the data set on whom these AVLT norms are based, this report revises the manner in which AVLT scores are summarized. Also, the methodology of converting AVLT scores to age-corrected and normalized MOANS Scaled Scores and then converting MOANS Scaled Score Sums to summary MAYO Indices (as used in related WAIS-R and WMS-R normative reports) is applied to these AVLT data. These revisions result in AVLT MOANS Scaled Scores and MAYO Auditory-Verbal Indices that are comparable to similar indices derived for the WAIS-R and the WMS-R.
Metrology for electron-beam lithography and resist contrast at the sub-10 nm scale

Exploring the resolution limit of electron-beam lithography is of great interest both scientifically and technologically. However, when electron-beam lithography approaches its resolution limit, imaging and metrology of the fabricated structures by using standard scanning electron microscopy become difficult. In this work, the authors adopted transmission-electron and atomic-force microscopies to improve the metrological accuracy and to analyze the resolution limit of electron-beam lithography. With these metrological methods, the authors found that sub-5 nm sparse features could be readily fabricated by electron-beam lithography, but dense 16 nm pitch structures were difficult to yield. Measurements of point- and line-spread functions suggested that the resolution in fabricating sub-10 nm half-pitch structures was primarily limited by the resist-development processes, meaning that the development rates depended on pattern density and/or length scale.