Miracle-dz/UniFAR-FTUs huggingface dataset:
Radiation Event Medical Management (REMM): Website Guidance for Health Care Providers

Planning for andexercising the medical response to potential chemical, biological, radiological, nuclear, andexplosive (CBRNE) terrorist events are new responsibilities for most health care providers. Among potential CBRNE events, radiological and/or nuclear (rad/nuc) events are thought to have received the least attention from health care providers andplanners. To assist clinicians, the U.S. Department of Health andHuman Services (HHS) has created a new, innovative tool kit, the Radiation Event Medical Management (REMM) web portal (http://remm.nlm.gov). Goals of REMM include providing (1) algorithm-style, evidence-based, guidance about clinical diagnosis andtreatment during mass casualty rad/nuc events; (2) just-in-time, peer-reviewed, usable information supported by sufficient background material andcontext to make complex diagnosis andmanagement issues understandable to those without formal radiation medicine expertise; (3) a zip-file of complete web portal files downloadable in advance so the site would be available offline without an Internet connection; (4) a concise collection of the printable, key documents that can be taken into the field during an event; (5) a framework for medical teams andindividuals to initiate rad/nuc planning andtraining; and(6) an extensive bibliography of key, peer-reviewed, andofficial guidance documents relevant to rad/nuc responses. Since its launch, REMM has been well received by individual responders andteams across the country andinternationally. It has been accessed extensively, particularly during training exercises. Regular content updates andaddition of new features are ongoing. The article reviews the development of REMM andsome of its key content areas, features, andplans for future development.
Modelling and analysing software requirements and architecture decisions under uncertainty

Early requirements engineering and software architectural decisions are critical to the success of software development projects. However, such decisions are confronted with complexities resulting from uncertainty about the possible impacts of decision choices on objectives; conflicting stakeholder objectives; and a huge space of alternative designs. Quantitative decision modelling is a promising approach to tackling the increasing complexity of requirements and architectural decisions. It allows one to use quantitative techniques, such as stochastic simulation and multi-objective optimisation, to model and analyse the impact of alternative decisions on stakeholders' objectives. Existing requirements and architecture methods that use quantitative decision models are limited by the difficulty of elaborating quantitative decision models and/or lack of integrated tool support for automated decision analysis under uncertainty. This thesis addresses these problems by presenting a novel modelling language and automated decision analysis technique, implemented in a tool called RADAR, intended to facilitate requirements and architecture decisions under uncertainty. RADAR's modelling language has relations to quantitative AND/OR goal models used in requirements engineering and feature models used in software product lines. The language enables modelling requirements and architectural decision problems characterised by (i) single option selection similar to mutually exclusive option selection (XOR-nodes) of feature diagrams; (ii) multiple options selection similar to non-mutually exclusive options selections (OR-nodes) of feature diagrams; and (iii) constraints dependency relationships, e.g., excludes, requires and coupling, between options of decisions. RADAR's analysis technique uses multi-objective simulation optimisation technique in evaluating and shortlisting alternatives that produces the best trade-off between stakeholders' objectives. Additionally, the analysis technique employs information value analysis to estimate the financial value of reducing uncertainty before making a decision. We evaluate RADAR's applicability, usefulness and scalability on a set of real-world systems from different application domains and characterised by design space size between 6 and 2E50. Our evaluation results show that RADAR's modelling language and analysis technique is applicable on a range of real-world requirements and architecture decision problems, and that in few seconds, RADAR can analyse decision problems characterised by large design space using highly performant optimisation method through the use of evolutionary search-based optimisation algorithms.
TO BE INDEPENDENT

All other reagents were independent of Mg 2 / and not inhibited by antibodies to the from previously described sources. 13,25 integrin a 2 b 1 . This suggests that the cross-linked peptides Preparation of human platelets. Human blood was taken from are unable to bind to a 2 b 1 and implies that activation is drug-free volunteers on the day of the experiment using acidic citrate mediated through an alternative cell surface receptor. This dextrose (ACD; 120 mmol/L sodium citrate, 110 mmol/L glucose, 80 ﬁnding is consistent with the two-step, two-site model for mmol/L citric acid) as anticoagulant. Platelet-rich plasma was obtained activation of platelets by collagen proposed by Morton et al 22 by centrifugation at 200 g for 20 minutes and incubated with 10 m Ci and Santoro et al 23 based on studies with cyanogen bromide [ 3 H]5-hydroxytryptamine (5-HT) for 60 minutes as required. Platelets fragments of collagen or acetylated collagen. The model were isolated by centrifugation at 1,000 g for 10 minutes in the presence predicts the presence of distinct determinants in the collagen of prostacyclin (0.1 m g/mL) and resuspended in 25 mL of a modiﬁed Tyrodes-HEPES buffer (134 mmol/L NaCl, 0.34 mmol/L Na 2 HPO 4 , 1 12 mmol/L NaHCO 3 , 20 mmol/L mmol/ face Platelets centrifuged at 1,000 g for in platelets. The results show the existence of a cell surface receptor other than a 2 b that is coupled to of cellular proteins including and 10%) and transferred to polyvinylidene diﬂuoride 144-249 was from Wako Chemicals (Tokyo, Japan). Rabbit anti-(PVDF) membranes by semidry transfer. Membranes were incubated PLC g 2 antiserum was generated as described. A suspension of for 30 minutes at room temperature with 10% (wt/vol) bovine serum type I collagen ﬁbers from equine tendon was obtained as Horm albumin (BSA) dissolved in TBS-T (20 mmol/L Tris, 137 mmol/L collagen from Nycomed (Munich, Germany). CRP was synthesized NaCl, Tween-20, pH and secondary and cross-linked as The MoAb 6F1 were diluted TBS-T containing 2% (wt/vol) BSA. For antiphos- recognizing the integrin a 2 -subunit was kindly donated by Dr B.S. photyrosine immunoblots, membranes were incubated with MoAb Coller (Mount Sinai School of Medicine, New York, NY). The rat MoAb 13 recognizing the human integrin b 1 -subunit was purchased 4G10 (dilution 1:1,000) for 60 minutes. Membranes were washed for 30 times more potent than collagen on a basis, with threshold and maximal effects at monomers approximately 30 times greater than Densitometric analysis. Densitometric analysis of ECL exposures performed using or Intelligent Quantiﬁer that inhibits activation of phospholipase C by sine phosphorylation was similar to that induced by the CRP monomer but smaller than that to CRP (not shown). These collagen by more than 90% also substantially inhibited the increase in tyrosine phosphorylation of these proteins (not observations provide evidence for interaction at a common site and that the CRP monomer is a partial agonist at this shown).
Generalized Stability Criterion of 3-D FDTD Schemes for Doubly Lossy Media

This paper presents the generalized stability criterion of 3-D finite-difference time-domain (FDTD) schemes for doubly lossy media, where both electric and magnetic conductivities coexist. The generalized stability criterion is applicable for all 3-D FDTD schemes, such as time-average (TA), time-forward (TF), time-backward (TB) and exponential time differencing (ETD). It is reducible to either electrically lossy, magnetically lossy or lossless media. The stability criterion for perfectly matched layer (PML) matching condition can also be obtained as a special case to the doubly lossy media. It is shown that, for doubly lossy media, the stability criterion for ETD and TF becomes even more relaxed, and for TB, even more stringent compared to either electrically lossy, magnetically lossy or lossless media. On the other hand, the stability criterion for TA remains unchanged even in doubly lossy media. As numerical demonstration, the tunneling of electromagnetic wave through a very thin doubly lossy conductor is simulated. Numerical experiments further show the maximum allowed time step as dictated by the derived stability criterion for different schemes.
Third- or second-generation parathyroid hormone assays: a remaining debate in the diagnosis of primary hyperparathyroidism.

BACKGROUND Since the demonstration that the second-generation PTH assays, also called intact PTH assays, recognize a non-1-84 PTH fragment in addition to the intact 1-84 PTH, new PTH assays defined as third-generation assays have been commercialized. Two previous studies aimed at evaluating whether these third-generation PTH assays improved the diagnostic sensitivity for primary hyperparathyroidism (PHPT), but they yielded opposite results. METHODS In the present study we compared two second-generation PTH assays (the total intact PTH assay from Scantibodies Laboratory, Inc., and the intact PTH assay from Nichols Institute Diagnostics) with two third-generation assays (the cyclase-activating PTH assay also from Scantibodies Laboratory and the bio-intact PTH assay from Nichols Institute) in a series of 145 consecutive PHPT patients operated in our endocrine surgery department over a 10-month period. A group of 74 healthy subjects served as controls. RESULTS The diagnostic sensitivities for PHPT of the total intact, the intact, the cyclase-activating, and the bio-intact assays were 93.8%, 97.3%, 84.2%, and 89.0%, respectively, with 95% confidence intervals in the control groups of 10-46, 11-60, 8.4-34, and 9-41 ng/liter, respectively. CONCLUSION Our findings demonstrate that the diagnostic sensitivities of second- and third-generation PTH assays are similar. Third-generation PTH assays do not therefore improve the diagnosis of elevated serum PTH levels in PHPT, although there are numerical differences among the values.
Are older adults really that different? Some insights from gerontechnology

Gerontechnology is a promising area of research. This study aims to extend knowledge in the area by providing an effective targeting strategy for gerontechnologies. Using near field communication (NFC)-enabled technology in the form of NFC light system (NLS), the study exposes a sample of older adults to this form of gerontechnology and examines their ease-of-use and usefulness evaluations of NLS and the subsequent impacts of these evaluations on their intentions to use NLS. Given a resulting scenario in which older adults considered NLS easy to use and useful, the study investigates whether demographic, psychographic, and behavioral characteristics produce any differences in their intentions to use NLS. The results reveal that older adults do not differ in their intentions to use NLS when demographics and psychographics are considered. Instead, older adults with positive attitudes toward NLS are more likely to use NLS than those with negative attitudes toward NLS. Thus, these findings suggest that an undifferentiated targeting strategy should be used for gerontechnologies, especially NFC-enabled technology, such as NLS, and that further research should concentrate on eliciting positive attitudes among older adults to persuade desired behaviors, such as greater intention to use and actual use of gerontechnologies.
Unleashing the Potential of CNNs for Interpretable Few-Shot Learning

Convolutional neural networks (CNNs) have been generally acknowledged as one of the driving forces for the advancement of computer vision. Despite their promising performances on many tasks, CNNs still face major obstacles on the road to achieving ideal machine intelligence. One is that CNNs are complex and hard to interpret. Another is that standard CNNs require large amounts of annotated data, which is sometimes very hard to obtain, and it is desirable to be able to learn them from few examples. In this work, we address these limitations of CNNs by developing novel, simple, and interpretable models for few-shot learn- ing. Our models are based on the idea of encoding objects in terms of visual concepts, which are interpretable visual cues represented by the feature vectors within CNNs. We first adapt the learning of visual concepts to the few-shot setting, and then uncover two key properties of feature encoding using visual concepts, which we call category sensitivity and spatial pattern. Motivated by these properties, we present two intuitive models for the problem of few-shot learning. Experiments show that our models achieve competitive performances, while being much more flexible and interpretable than alternative state-of-the-art few-shot learning methods. We conclude that using visual concepts helps expose the natural capability of CNNs for few-shot learning.
An integrated 200W class D audio amplifier

An integrated stereo class D audio power amplifier realized in an SOI based BCD technology is presented. The limiting factor in the performance of class D amplifiers is the quality of the switching power stage. In this paper a new high-speed, low-current levelshifter and a robust deadtime control arrangement are presented that are essential for a high quality switching power stage.
Repetitive Stresses Generate Osteochondral Lesions in Skeletally Immature Rabbits

Background: The origin of juvenile osteochondritis dissecans (OCD) is unknown. Existing experimental animal models of OCD most frequently involve surgically created lesions but do not examine repetitive stress as a possible cause of OCD. Hypothesis: Repetitive stresses can cause OCD-like lesions in immature animals. Study Design: Controlled laboratory study. Methods: Six juvenile rabbits were subjected to repetitive loading forces of approximately 160% body weight to the right hindlimb during five 45-minute sessions per week for 5 weeks. The contralateral limb was the unloaded control. After 5 weeks, rabbits were euthanized and examined with radiographs, micro–computed tomography, and gross and histopathologic analysis. Results: All 6 rabbits developed osteochondral lesions in loaded limbs on the medial and lateral femoral condyles, while contralateral unloaded limbs did not demonstrate lesions. Loaded limbs developed relative osteopenia in the femoral epiphysis and tibial metaphysis with associated decreased trabecular density. Loaded limbs also demonstrated increased femoral subchondral bone thickness near the lesions. Lesions did not have grossly apparent extensive articular cartilage damage; however, cartilage thickness increased on histology with reduced ossification. Loaded knees demonstrated abundant chondrocyte cloning, limited cartilage fissuring, and a focal loss of cellularity at the articular surface. Conclusion: Low-grade lesions in human OCD have little gross articular cartilage involvement despite substantial changes to the subchondral bone as shown on magnetic resonance imaging and radiographs. Histopathology findings in this study included cartilage thickening and chondrocyte cloning resembling those of recently published human OCD biopsy studies. Our animal model supports the hypothesis that repetitive stress to immature knees may contribute to the development of human OCD. This model may be useful in understanding the pathophysiology and healing of human OCD. Clinical Relevance: Repetitive physiologic stress generated changes to the subchondral bone in immature animals without causing extensive articular damage. The similarities of these lesions in gross and histologic appearance with human OCD support repetitive stress as the likely the cause for human OCD.
Isolation and characterization of induced genes under drought stress at the flowering stage in maize (Zea mays)

Maize female organs are sensitive to drought stress, leading to reproductive failure and yield reduction. In the present study gene expression profiles of ears and silks of maize at the flowering stage under drought stress were investigated. From 1920 white positive clones of a forward suppression subtractive hybridization (SSH) library, 1439 available sequences of expression sequence tags (ESTs) were obtained, resulting in 361 unique ESTs after assembling. Data analysis showed that 218 of the unique ESTs had significant protein homology by BLASTX in UNIPROT database. Totally 99 uniESTs were found in TIGR maize gene indices and nr database by BLASTN, while 44 uniESTs were not found to have homologous nucleic acid sequences and putatively classified as “maize-specific” uniESTs. The 218 cDNAs with significant protein homology were sorted into 13 groups according to the functional categories of the Arabidopsis proteins. Among those genes, the genes associated with the metabolisms were the largest group (account for 27%), and the genes related to protein synthesis, protein fate, transcription, cell cycle and DNA processing accounted for 16, 10, 10 and 9%, respectively. After analysis of macroarray data and real-time quantitative polymerase chain reaction (PCR), it was found that 160 of the 218 homologous protein uniESTs were up-regulated genes in the ears, 129 in the silks, and 125 in both of the tissues. The present work provided a valuable starting point for further elucidation of the roles played by these genes/gene products in drought tolerance in maize.
Levels of oxidative stress parameters and the protective effects of melatonin in psychosis model rat testis.

AIM To evaluate the effects of melatonin on antioxidant enzyme levels and histopathologic changes in dizocilpine (MK-801)-induced psychosis model rat testis. METHODS A total of 24 adult male Wistar-Albino rats were divided into three groups with 8 in each. Group I was used as control. Rats in Group II were injected with MK-801 (0.5 mg/kg body weight i.p. for 5 days). In addition to MK-801, melatonin (50 mg/kg body weight i.p. once a day for 5 days) was injected into the rats in Group III. The testes were harvested bilaterally for biochemical and histopathological examinations. Antioxidant enzyme activities, malondialdehyde, protein carbonyl and nitric oxide (NO) levels in testicular tissues were analyzed using spectrophotometric analysis methods. Histopathological examinations of the testes were also performed. RESULTS MK-801 induced testicular damage, which resulted in significant oxidative stress (OS) by increasing the levels of antioxidant enzymes. The malondialdehyde, protein carbonyl and NO levels were increased in testicular tissues of rats. Treatment with melatonin led to significant decrease in oxidative injury. Administration of melatonin also reduced the detrimental histopathologic effects caused by MK-801. CONCLUSION The results of the present study showed that MK-801 cause OS in testicular tissues of rats and treatment with melatonin can reduce the harmful effects of MK-801.
Effectiveness of a smoking cessation program for adolescents.

PURPOSE The purpose of this study was to test the effectiveness of a comprehensive smoking cessation program for Korean adolescents. METHOD The study design was quasi-experimental with one pre and three post-tests. The three posttests were done immediately after, three months later, and six months after the completion of the program. A total of 43 high school students who smoked participated in the study with 22 in the experimental group and 21 in the control group. The smoking cessation program consisted of 9 sessions with content on enhancement of self-efficacy, stress management, correction of distorted thoughts, consciousness raising, and assertiveness training. The study variables were urine cotinine levels, self-efficacy, stress, and stages of changed behavior. RESULTS Urine cotinine levels significantly decreased in the experimental group after the program (F=3.02, p=.06) but significantly increased in the control group (F=6.32, p=.004). Self-efficacy and the degree of stress did not change in either group. The stages of smoking cessation behavior tended to change when compared with raw data for the experimental group. For most participants, the stages of change had been precontemplation and contemplation, but changed to action and maintenance stage among the experimental group. CONCLUSION The program was effective in smoking cessation and influencing stages of change but did not change psychosocial factors such as self-efficacy and stress. It is suggested a program should be developed to change psychosocial variables on a long-term basis. It is also desirable to involve peers and families of adolescents who smoke when planning programs to enhance social support.
Targeting adenosine receptors to prevent inflammatory skin diseases

Adenosine mediates its effects through activation of a family of four G‐protein‐coupled receptors, named A1, A2A, A2B and A3. This nucleoside plays an important role in immunity and inflammation, and the A2A adenosine receptor subtype has a key role in the inhibition of inflammatory processes besides promoting wound healing. In this issue of Experimental Dermatology, Arasa et al. show that the topical application of a selective A2A agonist, CGS 21680, to mouse skin reduced epidermal hyperplasia as well as skin inflammation, similarly to topical corticoids, without side effects like skin atrophy. Rigorously following up this work is important for the development of novel treatment strategies for chronic hyperproliferative inflammatory dermatoses, such as targeting the A2A adenosine receptor family.