Miracle-dz/UniFAR-FTUs huggingface dataset:
OKL38 is an oxidative stress response gene stimulated by oxidized phospholipids Published, JLR Papers in Press, December 27, 2006.

Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) is present in oxidative modified LDL and accumulates in lesions of many chronic inflammatory diseases, such as atherosclerosis. In a microarray study, OxPAPC has been demonstrated to modulate the expression of >700 genes in human aortic endothelial cells. We found that the levels of mRNA for OKL38 [also named Bone marrow Derived Growth Factor (BDGI)], a tumor growth inhibitor, were strongly increased by OxPAPC. Here, we report that OKL38 is regulated by an oxidative signal induced by OxPAPC and its component lipid 1-palmitoyl-2-epoxyisoprostane E2-sn-glycero-3-phosphorylcholine. The stimulation of OKL38 by OxPAPC depends on superoxide production, because the NADPH oxidase (Nox) inhibitor apocynin and the superoxide scavenger N-acetyl cysteine block this stimulation. Oxidative stress by tert-butylhydroquinone treatment also induced the expression of OKL38. The stimulation of OKL38 expression by OxPAPC is mediated via transcription factor nuclear factor E2-related factor (Nrf2), a common factor involved in the regulation of oxidative stress-stimulated genes. Activation of Nrf2 induces the expression of OKL38, whereas small interfering RNA knockdown of Nrf2 blocks the stimulation of OKL38 by OxPAPC. Our results suggest that OKL38 is regulated via the Nox/Nrf2 pathway in response to oxidative stress stimuli.
Camera-based Online Flame-Stability-Monitor for Load-Flexible Biomass Co-Combustion

With an increasing share of fluctuating wind and solar power in the future energy system conventional combustion power plants have to enable a high load-flexibility. Additionally, a partial substitution of coal by biogenic fuels is desired. Especially in low load conditions a total shut down of a combustion plant has to be prevented. Instead, a stable low load operation has to be realized, e.g. by increasing the share of biogenic fuels with a lower calorific value, and thus decreasing the total power. Unfortunately, this usually leads to a destabilization of the flame, which – if detected – can partially be circumvented by adapting fuel-, airand swirl settings of the burner system. In this paper, a new image processing system for the online flame stability monitoring based on a camera system in the visual spectral range is presented. The flame stability monitor is demonstrated at a pilot scale power plant with co-combustion of torrified coal with hard coal.
One-year course of fatigue after post-operative radiotherapy in Norwegian breast cancer patients – comparison to general population

Abstract Introduction. Fatigue after treatment for breast cancer (BC) is common, but poorly understood. We examined the fatigue levels during first year after radiotherapy (RT) according to the extent of RT (local or locoregional), hormonal therapy (HT) and chemotherapy (CT). The impact of comorbidity was also explored. Moreover, we compared fatigue levels in patients with the general population (GenPop) data. Material and methods. BC patients (n = 250) referred for post-operative RT at St. Olavs Hospital, Trondheim, Norway, were enrolled. Fatigue was measured by the EORTC QLQ-C30-fatigue subscale, ranging from 0 to 100, before RT (baseline), after RT, and at three, six, and 12 months. Clinical and treatment-related factors were recorded at baseline. GenPop data was available from a previous survey (n = 652). Linear mixed models and analysis of covariance were applied. Results. Compliance ranged from 87% to 98%. At baseline, mean value (SD) of fatigue in BC patients was 26.8 (23.4). The level increased during RT (mean change 8.3, 95% CI 5.5–11.1), but declined thereafter and did not differ significantly from pre-treatment levels at subsequent time points. In age-adjusted analyses, locoregional RT accounted for more overall fatigue than local RT (mean difference 6.6, 95% CI 1.2–12.0), but the association was weakened and not statistical significant when adjusting for CT and HT. Similar pattern was seen for CT and HT. The course of fatigue differed significantly by CT (p < 0.001, interaction test). At baseline, fatigue levels were higher in patients with than without CT, but at subsequent time points similar levels were evident, indicating a temporary adverse effect of CT. Comorbidity was significantly associated with increased level of fatigue, independent of other factors (mean difference 8.1, 95% CI 2.2–14.1). BC-patients were not significantly more fatigued than GenPop, except for immediately after ending RT, and then only among those without comorbidity (mean 35.9 vs. 25.8, p < 0.001). Conclusion. Comorbidity seems to be a more important determinant for fatigue levels than the cancer treatment.
High Pressure Processing of Fruits and Vegetable Products: A Review

The nasty lifestyle of people in this fast moving world has made the people to think about their health and food. The growing concern about food born diseases and intense use of preservatives and chemicals has made the consumers to shift towards natural and healthy foods such as fruits and vegetables and high quality convenience foods in terms of natural flavor and taste, and which are free from additives and preservatives. This demand has triggered the need for the development of a number of non thermal approaches to food processing, of which high-pressure technology has proven to be very valuable. HPP is a clean non thermal processing technique applied to food materials for inactivating microorganisms and retaining quality at the highest level. HPP is the alternative to heat processing for fruit & vegetable products such as puree, coulis and sauces. It gets a significant shelf life extension, keeping fresh and home-made taste. The high pressure processing of fruit and vegetable products have their own advantages and disadvantages therefore, this paper reviews information on various fruit and vegetables products processed by HPP and its effect on various components, physical properties and microbial
Analysis of structural brain connectivity in 6 cases of hemispherectomy

Hemispherectomy is a surgical procedure for severe cases of epilepsy where an entire brain hemisphere is resected. Many patients maintain relatively normal cognitive function. Understanding how the brain's connections are organized in such cases is of interest and has not yet been explored. Using diffusion tensor imaging, we analyzed structural brain networks using various topological measures derived from brain connectivity matrices, to understand neural architecture in children with one brain hemisphere. We examined two measures derived from graph theory, global efficiency and modularity, using a k-core decomposition algorithm to compare two tractography methods and found distinctions in overall brain connectivity when comparing the two methods. While a normal control group was not available for direct comparison, this pilot study shows that it is feasible to study cortical connectivity in hemispherectomy patients.
Inter-Session Network Coding with Strategic Users: A Game-Theoretic Analysis of the Butterfly Network

We analyze inter-session network coding in a wired network using game theory. We assume that users are selfish and act as strategic players to maximize their own utility, which leads to a resource allocation game among users. In particular, we study a butterfly network, where a bottleneck link is shared by network coding and routing flows. We assume that network coding is performed using pairwise XOR operations. We prove the existence of Nash equilibrium for a wide range of utility functions. We also show that the number of Nash equilibria can be large (even infinite) for certain choices of parameters. This is in sharp contrast to a similar game setting with traditional packet forwarding, where the Nash equilibrium is always unique. We characterize the worst-case efficiency bound, i.e., the Price-of-Anarchy (PoA), compared to an optimal and cooperative network design. We show that by using a discriminatory pricing scheme which charges encoded and forwarded packets differently, we can improve the PoA in comparison with the case where a single pricing scheme is used. However, even when a discriminatory pricing scheme is used, the PoA is still worse than for the case when network coding is not applied. This implies that, although inter-session network coding can improve performance compared to routing, it is much more sensitive to users' strategic behavior.
Structural and Dynamical Features of Inteins and Implications on Protein Splicing*

Protein splicing is a posttranslational modification where intervening proteins (inteins) cleave themselves from larger precursor proteins and ligate their flanking polypeptides (exteins) through a multistep chemical reaction. First thought to be an anomaly found in only a few organisms, protein splicing by inteins has since been observed in microorganisms from all domains of life. Despite this broad phylogenetic distribution, all inteins share common structural features such as a horseshoe-like pseudo two-fold symmetric fold, several canonical sequence motifs, and similar splicing mechanisms. Intriguingly, the splicing efficiencies and substrate specificity of different inteins vary considerably, reflecting subtle changes in the chemical mechanism of splicing, linked to their local structure and dynamics. As intein chemistry has widespread use in protein chemistry, understanding the structural and dynamical aspects of inteins is crucial for intein engineering and the improvement of intein-based technologies.
Experimental evaluation of passage-based document retrieval

Retrieval of electronic documents is a fundamental component for intelligent access to the contents of documents. For the retrieval of long documents, a method called passage-based document retrieval has proven to be effective. In this paper we experimentally show that the passage-based retrieval is also advantageous for dealing with short queries on condition that documents are long. We employ a passage-based method based on density distributions of query terms in documents, and compare it with three conventional methods: the vector space model, pseudo-feedback and latent semantic indexing.
Internet Addiction Disorder and Its Pathogenicity to Psychological Distress and Depression among University Students: A Cross-Sectional Pilot Study in Bangladesh

Worldwide Internet addiction is a newly emerging mental health and social issue among the youths causing neurological complications, psychological disturbances and social problems. Internet addicts make the Internet urgency more vital than family, friends and work. Several studies exposed that anxiety, backache, blurred vision, dry eyes, headache, sleep disturbance, depression, poor academic performance etc. are results of Internet addiction. Therefore, the objective of this study was to determine the Internet addiction as well as its psychological distress and depression among university undergraduate students of Bangladesh. The study was conducted among 475 students selected from five universities of Bangladesh from July 2015 to September 2015. The selected universities were Southeast University, University of South Asia, Primeasia University, Northern University Bangladesh and State University of Bangladesh. Each willing participants were subject of this study and they shared their opinion. The Young’s Internet Addiction Test (IAT), the General Health Questionnaire (GHQ-12) and Beck Depression Inventory (BDI-2) were used to determine Internet addiction, psychological distress and depression respectively. Results revealed that the university students showed varying degrees of Internet addiction, psychological distress and depression with respect to sex, age, year of study and residential status. The data revealed that 47.7% (127) male and 44.5% (93) female students showed severe Internet addiction followed by 27.1% (72) male and 33.9% (71) female students showed moderate Internet addiction, while 20.7% (55) male and 7.7% (16) female students had mild Internet addiction. The linkage between Internet addiction and sex was significant at P < 0.001. Furthermore, 29.7% (79) male and 32.5% (68) female students had psychological distress. Severe psychological depression was reported among 44.7% (119) male and 41.6% (87) female students. Equally year of study and residential status showed significant (P < 0.001; P < 0.05, P < 0.001) differences in Internet addiction and psychological depression. This study observed that university undergraduate students are at very close to the danger of Internet addiction and its pathological impact on psychological distress and depression. Therefore, the new generation is at great risk. However, without Internet scientific thinking is not possible. So only the rational use of the Internet can be fruitful in the long run.
Design of emotion lighting control system on the power spectrum algorithm

Modern society is the emotional center of this design, each company has a number of factors are associated with emotions such as color and shape to fit the emotional paradigm focused to meet consumer sensibility. In this paper, the power spectrum algorithm proposed an algorithm for controlling the extracted emotional lighting a biological signal. LED lamp has been in use for emotional lighting is eco-friendly and has a high efficiency and prolonged lifetime. In particular, LED lighting has the advantage also possible that various color representation single light port. And it was used as a biological brain wave signals to determine more accurately the human emotions, analyze the collected brain waves using EEG equipment was considered an emotion.
Neurodevelopment of Amazonian Infants: Antenatal and Postnatal Exposure to Methyl- and Ethylmercury

Neurodevelopment as Gesell development scores (GDSs) in relation to mercury exposure in infants (<6 months of age) of one urban center and two rural villages, respectively, of fisherman and cassiterite miners. Mean total hair-Hg (HHg) concentrations of infants from Itapuã (3.95 ± 1.8 ppm) were statistically (P = 0.0001) different from those of infants from Porto Velho (3.84 ± 5.5 ppm) and Bom Futuro (1.85 ± 0.9 ppm). Differences in vaccine coverage among these populations resulted in significantly higher (P = 0.0001) mean ethylmercury (EtHg) exposure in urban infants (150 μg) than in infants from either village (41.67 μg, Itapuã; 42.39 μg, Bom Futuro). There was an inverse significant (Spearman r = −0.2300; P = 0.0376) correlation between HHg and GDS for infants from Porto Velho, but not for the rural infants from Bom Futuro (Spearman r = 0.1336; P = 0.0862) and Itapuã (Spearman r = 0.1666; P = 0.5182). Logistic regression applied to variables above or below the median GDS showed that EtHg exposure (estimated probability = −0.0157; P = 0.0070) and breastfeeding score (estimated probability = −0.0066; P = 0.0536) score were significantly associated with GDS. Conclusion. In nurslings whose mothers are exposed to different levels of fish-MeHg (HHg), a higher score of neurological development at six months was negatively associated with exposure to additional TCV-EtHg. Results should be interpreted with caution because of unaccounted variables.
First Report of Echinococcus equinus in a Donkey in Turkey

A 2-year-old female donkey (Equus asinus) was euthanized in the Pathology Department of Firat University, Elazig, Turkey. Necropsy disclosed the presence of 7 hydatid cysts distributed throughout the lung parenchyma. One of those cysts represented the parasite material of the present study and was molecularly identified through sequencing of a fragment of cytochrome c oxidase subunit 1 (CO1) and nicotinamide adenine dinucleotide dehydrogenase subunit 1 (NADH1) gene, as Echinococcus equinus. The generated CO1 sequence supports the presence of the dominant haplotype as has been described in Europe and Africa. The NADH1 sequence was found similar to sequences reported in equids in Egypt and the United Kingdom. The molecular identification of E. equinus in a donkey is being reported for the first time in Turkey.
Does Screw Configuration Affect Subtrochanteric Fracture after Femoral Neck Fixation?

A subtrochanteric femur fracture after cannulated screw fixation of a femoral neck fracture is a devastating complication. We hypothesized that an apex-distal screw orientation would tolerate higher loads to subtrochanteric fracture. Human cadaveric femora were instrumented with three cannulated screws in either an apex-distal or an apex-proximal configuration. Specimens were loaded along the mechanical axis to failure creating a subtrochanteric femur fracture. Ultimate load to failure and the effect of bone density on load to failure were compared between groups. There was a greater load to failure in the apex-distal group compared with the apex-proximal group. The mean force to fracture in the apex-distal group (11,330 N; standard deviation = 3151 N) was greater than the mean force to fracture in the apex-proximal group (7795 N; standard deviation = 3194 N). Previous investigations have shown improved femoral neck fixation with an apex-distal configuration, but none has examined the relationship between screw orientation and subtrochanteric fractures. Our observations support the use of an apex-distal configuration for cannulated screw fixation of femoral neck fractures.
Construction and Management of Doctor-Patient Privacy Protection System under Big Data Computing Environment

In the era of digital healthcare, protecting the privacy of doctors and patients has become an important challenge. The construction and management of privacy protection systems requires an integrated approach to ensure that the collection, storage and use of patient information both meets medical needs and maximizes the protection of physician and patient privacy. Therefore, this paper makes an in-depth analysis of the doctor-patient privacy protection system, describes and experiments the algorithms involved, and aims to improve the privacy protection system. This paper mainly uses experimental method and comparative method to design and analyze the privacy protection algorithm. The experimental results show that the information loss of the nearest far-point method is the largest when k value is 25, and the accuracy of a single algorithm in the system is difficult to meet the requirements, so it is necessary to add a transform-based mixed data micro-aggregation method to improve the performance of the system. This paper found that the privacy risk of medical data increases in the big data computing environment. Due to the large scale of data and the need for data sharing, doctor-patient privacy is even more threatened. Different privacy protection technologies, such as data desensitization, encryption and access control, can effectively reduce the risk of doctor-patient privacy leakage. There is a trade-off between privacy and data utility. Improving privacy protection may reduce the analyability and utility of data.
Nicotinamide treatment ameliorates the course of experimental colitis mediated by enhanced neutrophil-specific antibacterial clearance.

SCOPE In previous studies, we could show that the B vitamin nicotinamide (NAM) enhanced antimicrobial activity of neutrophils. Here, we assessed the effects of NAM in two models of experimental colitis. METHODS AND RESULTS Colitis was induced in C57BL/6 mice either by oral infection with Citrobacter rodentium or by DSS (dextran sodium sulphate) administration, and animals were systemically treated with NAM. Ex vivo bacterial clearance was assessed in murine and human whole blood, as well as isolated human neutrophils. In C. rodentium-induced colitis, NAM treatment resulted in markedly decreased systemic bacterial invasion, histological damage and increased fecal clearance of C. rodentium by up to 600-fold. In contrast, NAM had no effect when administered to neutrophil-depleted mice. Ex vivo stimulation of isolated human neutrophils, as well as murine and human whole blood with NAM led to increased clearance of C. rodentium and enhanced expression of antimicrobial peptides in neutrophils. Moreover, NAM treatment significantly ameliorated the course of DSS colitis, as assessed by body weight, histological damage and myeloperoxidase activity. CONCLUSION Pharmacological application of NAM mediates beneficial effects in bacterial and chemically induced colitis. Future studies are needed to explore the clinical potential of NAM in the context of intestinal bacterial infections and human inflammatory bowel disease (IBD).
Inter-procedural stacked register allocation for itanium® like architecture

A hardware managed register stack, Register Stack Engine (RSE), is implemented in Itanium® architecture to provide a unified and flexible register structure to software. The compiler allocates each procedure a register stack frame with its size explicitly specified using an alloc instruction. When the total number of registers used by the procedures on the call stack exceeds the number of physical registers, RSE performs automatically register overflows and fills to ensure that the current procedure has its requested registers available. The virtual register stack frames and RSE alleviate the need of explicit spills by the compiler, but our experimental results indicate that a trade-off exists between using stacked registers and explicit spills under high register pressure due to the uneven cost between them. In this work, we introduce the stacked register quota assignment problem based on the observation that reducing stacked register usage in some procedures could reduce the total memory access time of spilling registers, which includes the time caused by the loads/stores due to explicit register spills and RSE overflows/fills. We propose a new inter-procedural algorithm to solve the problem by allocating stacked registers across procedures based on a quantitative cost model. The results show that our approach can improve performance significantly for the programs with high RSE overflow cost, e.g. perlbmk and crafty, improved by 14% and 3.7%, respectively.
New Paradigms in Type 2 Immunity

Insights into Type 2 Immunity Different pathogens trigger characteristic immune responses. Although the immune responses against many bacteria, viruses, and fungi are relatively well understood, those against parasitic worms—termed type 2 responses—are much less so. Intriguingly, type 2 responses also mediate responses to allergens and allergic asthma. Pulendran and Artis (p. 431) review progress in understanding the signals that trigger type 2 immunity and the cellular responses that these responses initiate. Nearly half of the world’s population harbors helminth infections or suffers from allergic disorders. A common feature of this population is the so-called “type 2 immune response,” which confers protection against helminths, but also promotes pathologic responses associated with allergic inflammation. However, the mechanisms that initiate and control type 2 responses remain enigmatic. Recent advances have revealed a role for the innate immune system in orchestrating type 2 responses against a bewildering array of stimuli, from nanometer-sized allergens to 20-meter-long helminth parasites. Here, we review these advances and suggest that the human immune system has evolved multiple mechanisms of sensing such stimuli, from recognition of molecular patterns via innate immune receptors to detecting metabolic changes and tissue damage caused by these stimuli.
WISDOM2013: A Large-scale Web Information Analysis System

We demonstrate our large-scale web information analysis system called WISDOM2013, which consists of several deep semantic analysis systems such as a factoid QA, a non-factoid QA and a sentiment analyzer, and a software platform on which its semantic analysis systems can be applied to a billion-page-scale web archive. The software platform has an extendable architecture, and we are planning to enhance WISDOM2013 in the future by adding more semantic analysis systems and inference mechanisms.