Miracle-dz/UniFAR-FTUs huggingface dataset:
Distinct roles for plasma membrane PtdIns(4)P and PtdIns(4,5)P2 during receptor-mediated endocytosis in yeast

ABSTRACT Clathrin-mediated endocytosis requires the coordinated assembly of various endocytic proteins and lipids at the plasma membrane. Accumulating evidence demonstrates a crucial role for phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] in endocytosis but specific roles for phosphatidylinositol-4-phosphate [PtdIns(4)P], other than as the biosynthetic precursor of PtdIns(4,5)P2, have not been clarified. In this study we investigated the roles of PtdIns(4)P and PtdIns(4,5)P2 in receptor-mediated endocytosis through the construction of temperature-sensitive (ts) mutants for the phosphatidylinositol 4-kinases (PI4-kinases) Stt4p and Pik1p and the 1-phosphatidylinositol-4-phosphate 5-kinase [PtdIns(4) 5-kinase] Mss4p. Quantitative analyses of endocytosis revealed that both the stt4ts pik1ts and mss4ts mutants have a severe defect in endocytic internalization. Live-cell imaging of endocytic protein dynamics in stt4ts pik1ts and mss4ts mutants revealed that PtdIns(4)P is required for the recruitment of the α-factor receptor Ste2p to clathrin-coated pits, whereas PtdIns(4,5)P2 is required for membrane internalization. We also found that the localization to endocytic sites of the ENTH/ANTH domain-bearing clathrin adaptors, Ent1p, Ent2p, Yap1801p and Yap1802p, is significantly impaired in the stt4ts pik1ts mutant but not in the mss4ts mutant. These results suggest distinct roles in successive steps for PtdIns(4)P and PtdIns(4,5)P2 during receptor-mediated endocytosis. Summary: At the plasma membrane, PtdIns(4)P does not simply serve as an immediate precursor to PtdIns(4,5)P2, but plays a role in recruiting cargo to clathrin-coated pits during receptor-mediated endocytosis.
Effect of Melissa officinalis supplementation on growth performance and meat quality characteristics in organically produced broilers

Abstract 1. A trial was conducted to study the effect of Melissa officinalis supplementation on organic broiler performance and meat chemical, microbiological, sensory and nutritional quality. 2. Male and female day-old Ross 308 chicks were fed on a standard commercial diet containing 0, 2.5, 5 or 10 g/kg feed ground M. officinalis for 84 d before slaughter. 3. Weight gain and feed conversion ratio were significantly improved in the broilers receiving either 5 or 10 mg M. officinalis/kg feed. 4. Inclusion of M. officinalis did not affect muscle chemical and fatty acid composition. 5. On the basis of microbiological and sensory experimental data and subsequent extension of meat shelf life, M. officinalis did not reduce the microbial populations of the meat, but was effective in limiting lipid oxidation.
Multipractitioner Upledger CranioSacral Therapy: descriptive outcome study 2007-2008.

OBJECTIVES This study describes patients presenting for CranioSacral treatment, the conditions they present with, and the impact of treatment on both their symptoms and lives. DESIGN The records of 157 patients treated with Upledger CranioSacral Therapy (UCST) were reviewed. Seventy-three (73) patients had been treated by 10 different practitioners working independently and 84 patients were treated by a single practitioner working within the National Health Service. RESULTS Patients' ages ranged from neonates to 68 years. Seventy-four percent (74%) of patients reported a valuable improvement in their presenting problem. Sixty-seven percent (67%) also reported a valuable improvement in their general well-being and/or a second health problem. Outcome by diagnostic groups suggested that UCST is particularly effective for patients with headaches and migraine, neck and back pain, anxiety and depression, and unsettled babies. Seventy percent (70%) of patients on medication decreased or discontinued it, and patients' average general practitioner consultation rate fell by 60% in the 6 months following treatment. CONCLUSIONS The study suggests that further research into UCST as a treatment modality would be valuable for the abovementioned problems in particular.
Deterrence and the Impact of Calculative Thinking on Business Compliance with Regulation

Policy responses to corporate misconduct often advocate higher sanctions for better deterrence. This assumes that businesses make decisions about their regulatory compliance behaviour on the basis of self-interested calculations about the costs and gains of that behaviour. But policy-makers often assume that this automatically means higher sanctions will equal more compliance. This paper sets out a more holistic model of calculative thinking about the costs and gains of compliance and non-compliance. We go on to test this model using data about business compliance with Australian consumer protection and competition regulation. We find that enforcement probability is more important than sanction severity, and that business belief in the positive ‘business case’ for compliance is also important.
Business Strategy for Climate Change: An ASEAN Perspective

Business operations have been severely impacted by the increasing frequency and intensity of extreme weather conditions affecting economic development. Consequently, public pressure has been directed at businesses to build resilient and sustainable operations, especially in ASEAN countries, whose fragile natural environments make them among the most vulnerable to climate change. To better understand organisational responses, this study investigated the influence of internal resources and geographical regional effects on climate change business strategy. It provided empirical evidence from ASEAN countries based on the combined views of institutional and resource-based theories. Generally, ASEAN businesses were aware of climate change, and focused on strategies of fuel efficiency and greenhouse gas emissions reduction. Even though few businesses integrated climate change into their business strategy, there are several factors (board of directors with international experience, organisational slack, and country effect) that influence ASEAN climate change business strategy. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
On the star, delta and star-delta stator winding connections tolerance to voltage unbalance

When a three-phase squirrel-cage induction motor is to be started with an electronic soft-starter, the respective stator winding can be designed for nominal power with delta, star or star-delta connection. If the motor has two sets of windings sharing the same slots, which may be connected in series or parallel, more connection modes are possible. In this paper, on the basis of a theoretical approach, simulations, and some experiments, a comparative analysis of the tolerance to voltage unbalance of the delta, star and star-delta stator winding connections is presented, offering a new perspective on this issue. It is demonstrated that, under unbalanced voltage supply condition, these stator winding connection modes have a different performance in terms of phase voltage and current unbalance ratios.
Enhancing QoS of Wireless Sensor Network by detection of faulty sensor node

In nigh application, it is indispensable to discover or supervise the behavior of the surrounding situation at a fine resolution over large spatial-temporal scales therefore WSN (Wireless Sensor Network) is well-advised. Because of smaller size and low power requirement of sensor device use of WSN for watching the surrounding action is increased time to time. Numeral of sensor inside WSN is proportionate to the WSN accuracy. As WSN may be operated in unsupervised and aggressive environment because of this probability of failure of sensor node inside WSN is increased. If any of the sensor node is failed, this will lead to the change the WSN topology, also create network separation, increases the distance between a node pair and reduce secondary available shortest routes. Due to this quality of service (QoS) of WSN will be degraded, to improve QoS of WSN, we have to find out faults within the network. This paper represents the easiest way for finding the defective sensing element inside the network. This method measure Round Trip Time (RTT) and throughput of the Round Trip Path (RTP) and compare the calculated RTT and throughput with threshold values (threshold value for RTT (Th (rtt)) and throughput (Th (throughput))) based on a comparison result we will find a faulty sensor within the network.
Forensic applications of a rapid, sensitive, and precise multiplex analysis of the four short tandem repeat loci HUMVWF31/A, HUMTH01, HUMF13A1, and HUMFES/FPS

A system of four short tandem repeat loci (HUMVWF31A, HUMTH01, HUMF13A1, and HUMFES/FPS) has been tested in co‐amplification with forensic (post‐mortem and post‐coital) DNA samples. Semiautomated DNA typing was employed to analyze polymerase chain reaction (PCR) products formed by extension of primers labeled with a fluorescent dye at the 5′‐terminus. Most DNA extracts could be typed, although a few required the addition of bovine serum albumin or a pretreatment by ultrafiltration in order to obtain sufficient signal for typing. Balanced signals for the alleles were obtained frequently across the loci, although preferential amplification of HUMTH01 was observed often with the forensic samples. Band splitting due to nontemplate nucleotide addition to the blunt ends of the amplimers was frequently detected for the DNA extracted from the forensic samples. A database was constructed for the African‐American population and compared with a Caucasian database. Few differences were observed across the two populations, except at the locus HUMTH01. The fluorescence‐based system facilitates large‐scale databasing, because the PCR products run off the gel, allowing more than one set of samples to be analyzed per run. Polyacrylamide gel reuse did not diminish genotyping accuracy.
A signal processing framework for the analysis and application of chaotic systems

Abstract : One contribution of chaos theory to the engineering research community is the notion that complex, erratic behavior in physical systems need not be the result of stochastic phenomena-such phenomena may result from deterministic mechanisms. This idea has been used in the analyses of several engineering systems. Perhaps more interesting are the several proposed engineering applications that take advantage of the structure of signals generated by chaotic systems. In order to take full advantage of the unique properties of chaotic signals in future applications, this structure must be well characterized. This thesis explores two aspects of this issue-the statistical structure of chaotic signals and the to linear distortion of chaotic signals. In the first portion of the thesis, we concentrate on the time-average behavior of signals generated by chaotic systems with one state variable. Using an analogy between such signals and stationary stochastic processes, we present a framework for analyzing the statistical properties of these chaotic signals. In particular, we provide readily computable analytic expressions for a broad class of statistics of a large class of chaotic signals. We also present a technique for approximating the statistics of certain chaotic signals for which exact results are unavailable. As an example of the utility of these results, we use them to determine the power spectra of chaotic signals and to analyze a model of a switching DC-DC power converter operating in a chaotic regime. In the second portion of the thesis, we concentrate on chaotic signals that have been linearly filtered. Such signals may arise, for example, when chaotic phenomena are measured through sensors with linear dynamics. We present results relating certain parameters of the original and distorted signals.
a novel approach

Purpose:We present a new approach for urine drainage in pediatric patients following laparoscopic pyeloplasty, the trans-ureterocystic external urethral stent (TEUS). Methods: We retrospectively identified 85 children who underwent laparoscopic pyeloplasty from July 2015 to June 2017. The included children were assigned to group A (double-J stent) or group B (TEUS). In group A, the double-J stent was removed by a cystoscopy under anesthesia after 1 month, while in group B, the external stent was removed after 5 to 7 days. We examined the durations of operation, hospital stay and the frequency of stent-related complications including urinary leakage, stent dislocation, stent occlusion, and urinary tract infection. Results: The operation time was significantly longer for patients in group B than for those in group A. No significant difference was observed between the groups regarding stent-related complications. In group A, 4 patients need auxiliary stent re-insertion for the management of complications, 2 developed urinary tract infection, and 2 had stent occlusion. In group B, none needed auxiliary stent re-insertion for complications and avoided re-operation. Conclusions: In children, the outcome of external stent implantation was similar to that using double-J stent, and the use of the former approach may be beneficial for younger children. Abbreviations: APRPD = anterior-posterior renal pelvic diameter, CT = computed tomography, FDA = Food and Drug Administration, IVU = intravenous urogram, TEUS = trans-uretero-cystic external urethral stent, UPJO = ureteropelvic junction obstruction.
Kinodynamic Planning for Humanoid Robots Walking on Uneven Terrain

For the purpose of realizing the humanoid robot walking on uneven terrain, this paper proposes the kinodynamic gait planning method where both kinematics and dynamics of the system are considered. We can simultaneously plan both the foot-place and the wholebody motion taking the dynamical balance of the robot into consideration. As a dynamic constraint, we consider the differential equation of the robot’s CoG. To solve this constraint, we use a walking pattern generator. We randomly sample the configuration space to search for the path connecting the start and the goal configurations. To show the effectiveness of the proposed methods, we show simulation and experimental results where the humanoid robot HRP-2 walks on rocky cliff with hands contacting the environment.
Complements or Substitutes? Internal Technological Strength, Competitor Alliance Participation, and Innovation Development

While a firm can choose to develop an innovation internally or externally, the internal knowledge development and external knowledge acquisition tend to interact with each other in the innovation process. The present study examines whether internal technological strength and external competitor alliance participation serve as complements or substitutes in innovation development. Built on the knowledge-based view, this study offers a contingency perspective on the nature of knowledge integration between internal technological strength and external alliance relationships, and how they jointly influence radical and incremental innovation differently. Adopting a random effect negative binomial model specification, a panel data set of 64 pharmaceutical firms over a 15-year period were used to test the hypothesized effects. The findings indicate that internal technological knowledge strength has an inverted U-shaped relationship with radical and incremental innovation. More importantly, the findings also demonstrate that the combined effect of internal and external sources of innovation can have differential effects on radical and incremental innovation development. Specifically, competitor alliance participation strengthens the effect of internal technological strength on incremental product innovation while it weakens the above effect on radical product innovation. This suggests that internal and external sources of innovation may complement each other for incremental innovation while they may represent trade-offs for radical innovation development. The above findings provide empirical evidence for the complexity of pursuing organizational ambidexterity in innovation generation and highlight the importance of balancing the internal and external knowledge sources in pursuing innovation.
Trading Activity and Exchange Rates in High-Frequency EBS Data

The absence of data has, until now, precluded virtually all research on trading volume in the foreign exchange market. This paper introduces a new high-frequency foreign exchange dataset from EBS (Electronic Broking Service) that includes trading volume in the global interdealer spot market. The dataset gives volumes and prices at the one-minute frequency over a five-year time period in the euro-dollar and dollar-yen currency pairs. We first document intraday volume patterns in euro-dollar and dollar-yen trading, noting the effects of macroeconomic news announcements but also purely institutional factors. We study the effects of UK-specific holidays on euro-dollar and dollar-yen trading volume and find that these holidays cause a sharp decline in trading volume even among dealers outside the UK, a natural experiment that we interpret as further evidence that trading activity is not driven solely by the flow of news about fundamentals. Studying the reaction to U.S. macroeconomic announcements, we show that a sharp pickup in trading volume generally occurs in the minutes following news announcements. This rise in trading volume happens even if the data release is entirely in line with market expectations, and it is often negatively related to the dispersion of ex-ante market expectations. Finally, focusing on one particular data release at the one-second frequency, we document a two-stage reaction whereby the price jumps immediately after the announcement without much trading volume, while trading volume and volatility then surge about 15 seconds after the data release.
Challenges and Opportunities in Managing the Dizzy Older Adult

Balance disorders are common in elderly people, not only resulting in distressing sensations but also leading to reduced activity levels and quality of life. It has been estimated that 30% of elderly patients experience a balance disorder. Managing these disorders is a substantial challenge for patients and their caregivers and physicians. Moreover, abnormalities in balance are associated with falls, a major cause of morbidity and mortality for elderly people. Management is complicated by the inherent difficulties in assessing the generic complaint of dizziness, as well as the likelihood of multiple, often nonvestibular causes. The authors of this mini-seminar review both vestibular and nonvestibular causes of balance disorders in elderly people, emphasizing practical therapeutic maneuvers that can be used.
A model for the formation of orientation columns

A mathematical model is proposed to describe the formation of orientation columns in mammalian visual cortex. The model is similar in concept to that proposed for ocular dominance column formation (Swindale 1980), the essential difference being that orientation is a vector rather than a scalar variable. It is assumed that initially orientation selectivity is weak and randomly distributed, and that selectivity develops in such a way that the orientation preferences of neurons less than about 200 μm apart tend to change in a similar direction, whereas the preferences of cells further apart tend to develop in opposite directions. No hypotheses are made about the anatomical or physiological basis of these interactions, and it is not necessary to assume that they are the result of environmental stimulation, as with existing models for the the development of orientation selectivity (see, for example, von der Malsburg, 1973). The model reproduces the experimental data on orientation columns: roughly linear sequences of orientation change are produced, and these alternate unpredictably between clockwise and anticlockwise directions of change. Continuous sequences may span several 180° cycles of rotation. The sequences are generally smooth, but abrupt discontinuities of up to 90° also occur. The iso-orientation domains for large orientation ranges (60–90°) are periodically spaced branching stripes that resemble those demonstrated in animals by the 2-deoxyglucose technique. The domains for narrower orientation ranges are periodically spaced but are more irregular in shape, though sometimes thin and elongated. The model makes a number of predictions that can be tested experimentally. Of particular interest are the discontinuities in the orientation sequences: these should be distributed with a spacing roughly equal to, or half, that of the iso-orientation domains. Each should be surrounded by one or two complete sets of iso-orientation domains, and each may be associated with regions where cells are not orientation selective. These regions may be more extensive in younger animals, when the columns are at an intermediate stage of formation, and less numerous where the columns run parallel and unbranched over large areas.
High gain crank line antenna for 24 GHz

We present a high gain 24 GHz crank line (CL) antenna fed by a modified Wilkinson power divider (WPD) network. The CL is formed by four parallel Rampart arrays transmitting a circularly polarized wave. With the WPD we achieve a uniform coupling of the Rampart structures and an impedance transformation from 50 Omega to the 100 Omega antenna impedance. The gain of the antenna is 20 dBi in the frequency range from 23.6 GHz to 24.6 GHz
Study on the Degree of the Network Connectivity of Expressways Operated in the Closed-type Toll Collection System

The Korea Expressway Corporation collects tolls in all expressways in its charge under the Toll Road Act establishing user pay principle, cost recovery method, and integratedprofit system as legal bases for collecting tolls. However, the act does not clearly stipulate the methodology how to measure the connectivity in terms of transportation, which is one of requirements for the adaptation of integrated-profit system, so that there have been lots of arguments on collecting tolls on the expressways. Thus, this research effort developed a transportation-connectivity index to estimate the degree of the connectivity of expressways in terms of physical linkage and actual usage. The index was validated using TCS and Hi-Pass data collected from expressways operated under the closed-type toll collection system. Conclusively, the connectivity indexes of the subject expressways in use are over 2.0 in general, which mean all the subject expressways are physically well connected and multiple expressway routes are frequently and simultaneously used.
Impaired facial and vocal emotion decoding in schizophrenia is underpinned by basic perceptivo-motor deficits*

ABSTRACT Introduction: Emotional decoding impairments have been largely demonstrated in schizophrenia for facial and prosodic stimuli, when presented separately. Nevertheless, the exploration of crossmodal integration has been far less considered, despite its omnipresence in daily social interactions. Moreover, the role played by basic visuo-motor impairments in unimodal and crossmodal decoding remains unexplored. Methods: Thirty-two patients were compared with 32 matched controls in an emotional decoding task including unimodal (visual and auditory) and crossmodal (congruent and incongruent) conditions. A control perceptive task was also conducted to take potential low-level perceptual deficits into account. Results: Schizoprenic patients presented lower performance and higher reaction times for both unimodal tasks (visual and auditory) and crossmodal conditions. Moreover, reaction times for the visuo-perceptive task were also significantly longer for patients compared to controls. Conclusions: The consistency of the results across unimodal and crossmodal tasks suggests a globalised emotional impairment in schizophrenia, independent of the sensorial modality and crossmodal nature of the stimuli. Centrally, given the results in the visuo-perceptive task, the impairments observed for emotional recognition appears at least partly explained by primary cognitive deficits, namely reduced processing speed.