Miracle-dz/UniFAR-FTUs huggingface dataset:
Intrathecal Injection of Resveratrol Attenuates Burn Injury Pain by Activating Spinal Sirtuin 1

Objective: The present study sought to detect spinal sirtuin 1 (SIRT1) and acetylation of histone H3 (Ac-H3) expression in rats with burn injury pain (BIP model). Procedures and Results: A BIP model was first established. BIP rats showed lower paw withdrawal threshold (PWT) from day 1, which persisted for 21 days following the burn injury. Spinal SIRT1/Ac-H3 expression increased following burn injury. The intrathecal use of resveratrol increased PWT and SIRT1 expression but induced down-regulation of Ac-H3 expression. We first demonstrated that the inhibition of SIRT1 significantly induced mechanical allodynia in naïve rats. The preinjection of SIRT1 inhibitor partly antagonized the analgesic effects of resveratrol in BIP rats. Conclusion: Inhibition of SIRT1 produces pain facilitation in the naïve rats. The expression of spinal SIRT1 increased after burn injury in the BIP model. The activation of spinal SIRT1 might mediate the resveratrol-induced analgesic effects. SUMMARY Burn injury resulted in pain facilitation Resveratrol attenuates pain facilitation induced by burn injury Intrathecal injection of resveratrol attenuates burn injury pain by increasing spinal sirtuin 1 (SIRT1) expression Inhibition of SIRT1 by selisistat, an SIRT1 inhibitor attenuated analgesic effects of resveratrol. Abbreviations used: SIRT1: Sirtuin 1, Ac-H3: Acetylation of histone H3, SD: Sprague-Dawley, EX527: Selisistat, an SIRT1 inhibitor, BIP: Burn injury pain, DMSO: Dimethyl sulfoxide, PWTs: Paw withdrawal thresholds Zhi-Jian Fu
CED-9 and mitochondrial homeostasis in C. elegans muscle

Mitochondrial homeostasis reflects a dynamic balance between membrane fission and fusion events thought essential for mitochondrial function. We report here that altered expression of the C. elegans BCL2 homolog CED-9 affects both mitochondrial fission and fusion. Although striated muscle cells lacking CED-9 have no alteration in mitochondrial size or ultrastructure, these cells appear more sensitive to mitochondrial fragmentation. By contrast, increased CED-9 expression in these cells produces highly interconnected mitochondria. This mitochondrial phenotype is partially suppressed by increased expression of the dynamin-related GTPase DRP-1, with suppression dependent on the BH3 binding pocket of CED-9. This suppression suggests that CED-9 directly regulates DRP-1, a model supported by our finding that CED-9 activates the GTPase activity of human DRP1. Thus, CED-9 is capable of regulating the mitochondrial fission-fusion cycle but is not essential for either fission or fusion.
Retest-Reliabilität und Änderungssensitivität des ICD-10-Symptom-Rating (ISR) in verschiedenen Stichproben

Assessment of the retest-reliability and sensitivity to change of the ICD-10-Symptom-Rating (ISR) is provided. The ISR was filled out repeatedly by a non-clinical as well as different samples of psychosomatic patients. Between the two measurements either no or an integrated psychosomatic treatment took place. During the treatment free phase a high degree of stability of the test scores was expected, whereas a significant improvement of test scores was expected for the respective scales over the treatment phase. The retest-reliability for the individual scales ranges from 0.70 to 0.94. Between admission to a psychosomatic treatment and discharge significant differences were found for all scales. The retest-reliability showed satisfactory results comparable to similar, symptom-oriented instruments. Furthermore, the instruments reproduces symptomatic changes consistently and is - from our point of view - suitable for the assessment of change.
Preparation and characterization of a [14C]cellulose suitable for human metabolic studies

In six normal subjects administered 5 μCi of an oral dose of a commercially available 14C-labelled cellulose, significant amounts of 14CO2 were detected in expired air within 30 min, suggesting that other 14C-labelled non-cellulosic material was present. Chemical and microscopical examination confirmed that starch was the principal contaminant. The commercial preparation was purified using amyloglucosidase (EC 3.2.1.3) digestion following gelatinization of the starch by autoclaving. Subsequent administration of the purified cellulose to a further six normal subjects decreased the expired air 14CO2 during the subsequent 10 h from 13.0 (sd 4.0) to 4.1 (sd 1.9)%. Administration of the purified product to a further group of four normal subjects, before and after a regimen of increased dietary fibre, showed a cumulative increase in expired 14CO2 over 24 h from 7.9 (sd 1.1) to 12.1 (sd 2.6) % on fibre. In six ileostomy subjects the cumulative excretion of 14CO2 was greatly decreased compared with normal controls (3.0 (sd 1.14) and 10.5 (sd 3.9) % respectively). In constipated subjects expired 14CO2 continued beyond 48 h, in contrast to normal subjects where expired 14CO2 at this time was negligible.
High-temperature performance of GaAs-based HFET structure containing LT-AlGaAs and LT-GaAs

Using low-temperature grown layers a GaAs-based HFET structure was developed, which demonstrates for the first time high performance at high temperatures up to 540/spl deg/C, where the gate diode shunts through. The device was designed for operation in the hot electron regime using an LT-AlGaAs passivation layer. Thus, the open channel current density and gain bandwidth product are exceptionally stable (I/sub D500/spl deg/C//I/sub DR.T./=0.9; f/sup T200/spl deg/C/f/sub TR.T./=0.9). The f/sub max/ cutoff frequency is the most temperature sensitive parameter {(f/sub max//f/sub T/)/sub R.T. /=3.9 and (f/sub max//f/sub T/)/sub 200/spl deg/C/=2.8} due to the thermal activation of the buffer layer leakage, which is kept extremely small using LT-GaAs.
Redundancy Reduction for Prevalent Co-Location Patterns

Spatial co-location pattern mining is an interesting and important task in spatial data mining which discovers the subsets of spatial features frequently observed together in nearby geographic space. However, the traditional framework of mining prevalent co-location patterns produces numerous redundant co-location patterns, which makes it hard for users to understand or apply. To address this issue, in this paper, we study the problem of reducing redundancy in a collection of prevalent co-location patterns by utilizing the spatial distribution information of co-location instances. We first introduce the concept of <italic>semantic distance</italic> between a co-location pattern and its super-patterns, and then define redundant co-locations by introducing the concept of <italic> δ-covered</italic>, where <inline-formula><tex-math notation="LaTeX">$\delta \,(0\leq \delta \leq 1)$</tex-math> <alternatives><inline-graphic xlink:href="wang-ieq1-2759110.gif"/></alternatives></inline-formula> is a coverage measure. We develop two algorithms <italic>RRclosed</italic> and <italic>RRnull</italic> to perform the redundancy reduction for prevalent co-location patterns. The former adopts the <italic>post-mining</italic> framework that is commonly used by existing redundancy reduction techniques, while the latter employs the <italic>mine-and-reduce </italic> framework that pushes redundancy reduction into the co-location mining process. Our performance studies on the synthetic and real-world data sets demonstrate that our method effectively reduces the size of the original collection of closed co-location patterns by about 50 percent. Furthermore, the RRnull method runs much faster than the related closed co-location pattern mining algorithm.
Chinese Wine Classification Using BPNN through Combination of Micrographs' Shape and Structure Features

Chinese wines of different wine styles and varieties have different microstructure, and their micrograph show floccule,stick and granule of variant shape and size. Chinese wines can be classification or graded by the micrographs. Shape and structure of wines' particles in microstructure is the most important feature for recognition and classification of wines. After denoising and segment of micrographs, we describe a set of structure and shape features that can be used to characterize these micrographs. We introduce Euler distance, total number of regions and the combination of shape feature of different regions to describe the structure and region shape of micrograph. Seven kinds total 22 features are selected.Then Chinese wine classification system based on micrograph using combination of shape and structure features and BPNN have been presented. We compare classification results for different choices of features, and find that the best results could be obtained using the combination of shape and structure features.
Web page classification using firefly optimization

Increase in the amount of information on the Web has caused the need for accurate automated classifiers for Web pages to maintain Web directories and to increase search engines' performance. As every (HTML/XML) tag and every term on each Web page can be considered as a feature, we need efficient methods to select best features to reduce feature space of the Web page classification problem. In this study, our aim is to apply a recent optimization technique namely the firefly algorithm (FA), to select best features for Web page classification problem. The firefly algorithm (FA) is a metaheuristic algorithm, inspired by the flashing behavior of fireflies. In this study, we use FA to select a subset of features, and to evaluate the fitness of the selected features J48 classifier of the Weka data mining tool is employed. WebKB and Conference datasets were used to evaluate the effectiveness of the proposed feature selection system. We observed that when a subset of features are selected by using FA, WebKB and Conference datasets were classified without loss of accuracy, even more, time needed to classify new Web pages reduced sharply as the number of features were decreased.
Effects of Additional Administration of Low-Dose Indapamide on Patients With Hypertension Treated With Angiotensin II Receptor Blocker

Background: Low-dose thiazide or thiazide-like diuretics have proven useful for the management of blood pressure in patients older than 65 years (elderly group). However, there are few reports about the antihypertensive effects of antihypertensive diuretic agents in patients younger than 65 years (middle-aged group). So, we evaluated the efficacy of low-dose indapamide on blood pressure. Methods: Indapamide(1 mg) was given daily for 3 months and was then given every other day for 3 months to patients whose hypertension was poorly controlled with angiotensin II receptor blocker (ARB)-based treatment. Results: After daily administration of indapamide, blood pressure was significantly decreased in both the middle-aged and elderly groups. Blood pressure was not significantly changed by every-other-day administration compared with that observed after daily administration in either group. The rate of attainment of the target blood pressure was 90.3% and 85.7% in the middle-aged and elderly groups, respectively. The serum uric acid levels were reduced after every-other-day administration compared to daily administration but tended to be higher than the levels at the baseline in both groups. Conclusions: The addition of low-dose indapamide is a useful strategy for the management of hypertension, as it reduced blood pressure without marked side effects.
Survivors of acute respiratory distress syndrome: Relationship between pulmonary dysfunction and long-term health-related quality of life*

Background:Patients who survive acute respiratory distress syndrome (ARDS) often report decreased general health-related quality of life (HRQOL) following hospital discharge. The extent to which this impairment is due to pulmonary or nonpulmonary causes is unclear. We describe the pattern of recovery of patients surviving ARDS to illuminate any relationships between lung spirometry values, pulmonary symptoms, and overall HRQOL. Methods:Seventy-three survivors of ARDS were enrolled in a 12-month follow-up study as part of a phase III randomized, multicenter trial. Patients were contacted at 3, 6, and 12 months after enrollment to complete generic and disease-specific HRQOL questionnaires and have lung spirometry tests performed. Results:For all domains of the Medical Outcomes Study Short Form-36 (SF-36) and the St. George’s Respiratory Questionnaire (SGRQ) at all time intervals, survivors of ARDS had significantly lower scores than age- and sex-matched population values. Over the 12-month follow-up period, we observed significant improvements to the overall Physical Component Score, but the Mental Component Score of the SF-36 and the SGRQ scores were not statistically different. Physical performance measures suggested that by 12 months, 57% had not returned to “normal activity. ” At 12 months, lung spirometry tests demonstrated mild abnormalities that were stable over time (64% and 49% had <80% predicted forced expiratory volume in 1 sec [Fev1] and forced vital capacity [Fvc], respectively). At 12 months, the forced expiratory volume in 1 sec correlated strongly with the physical function domain of the SF-36 (correlation coefficient = 0.601; p < .01) and moderately with all domains of the SGRQ (correlation coefficient = −0.36, −50; p < .01 in all cases). In addition, there were several strong to moderate correlations between the various domains of the SF-36 and SGRQ. Conclusions:Survivors of ARDS have considerable respiratory symptoms and reduced HRQOL that is still prevalent at 12 mos following onset of injury. There are significant correlations between lung spirometry, pulmonary symptoms, and overall HRQOL, thus suggesting the acute lung injury/ARDS is causally contributing to the observed long-term outcome.
Validation of a Decisional Conflict Scale

The study objective was to evaluate the psychometric properties of a decisional conflict scale (DCS) that elicits: 1) health-care consumers' uncertainty in making a health-related decision; 2) the factors contributing to the uncertainty; and 3) health-care consumers' perceived ef fective decision making. The DCS was developed in response to the lack of instruments available to evaluate health-care-consumer decision aids and to tailor decision-supporting interventions to particular consumer needs. The scale was evaluated with 909 individuals deciding about influenza immunization or breast cancer screening. A subsample of respon dents was retested two weeks later. The test-retest reliability coefficient was 0.81. Internal consistency coefficients ranged from 0.78 to 0.92. The DCS discriminated significantly (p < 0.0002) between those who had strong intentions either to accept or to decline invitations to receive influenza vaccine or breast cancer screening and those whose intentions were uncertain. The scale also discriminated significantly (p < 0.0002) between those who ac cepted or rejected immunization and those who delayed their decisions to be immunized. There was a weak inverse correlation (r = - 0.16, p < 0.05) between the DCS and knowledge test scores. The psychometric properties of the scale are acceptable. It is feasible and easy to administer. Evaluations of responsiveness to change and validation with more difficult decisions are warranted. Key words: measurement; decision making; immunization; breast cancer screening. (Med Decis Making 1995;15:25-30)
Restaurant foods, sugar-sweetened soft drinks, and obesity risk among young African American women.

BACKGROUND The prevalence of obesity is disproportionately high in African American women, and consumption of fast foods and sugar-sweetened soft drinks is also especially high among African Americans. OBJECTIVE We investigated the relation of intakes of sugar-sweetened soft drinks and specific types of restaurant foods to obesity in the Black Women's Health Study. DESIGN In this prospective cohort study, 19,479 non-obese women aged 21-39 years at baseline were followed for 14 years (1995-2009). Dietary intake was assessed by validated food frequency questionnaire in 1995 and 2001. MAIN OUTCOME MEASURES Cox regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of intakes of restaurant foods and sugar-sweetened soft drinks with incident obesity. RESULTS Higher intakes of burgers from restaurants and sugar-sweetened soft drinks were associated with greater risk of becoming obese. The associations were present in models that included both factors and adjusted for overall dietary pattern. The HR of obesity in relation to restaurant burger consumption of > or = 2 times/week compared with < 5 times/year was 1.26 (95% CI: 1.14-1.40; P-trend<.001). For sugar-sweetened soft drink intake, the HR was 1.10 (95% CI: .99-1.23; P-trend = .14) for > or = 2 drinks/day compared with < 1 drink/month. The associations were stronger among women younger than age 30 with normal weight at baseline. CONCLUSIONS Frequent consumption of burgers from restaurants and sugar-sweetened soft drinks contribute to obesity among young African American women.
Performance of phasor measurement units for wide area real-time control

Phasor Measurement Units (PMU) are becoming a basic building block of modern wide area power system protection, monitoring and control schemes. Such systems rely on accurate time synchronized measurements. PMU operation is governed by the IEEE C37.118 standard. The standard sets out the performance requirements for valid phasor measurements under steady state conditions, but does not specify the response of PMUs under transient system conditions. Since most events requiring action by protection and control systems arise from transients it is important that PMUs report these anomalies in an understood and universal manner. This paper discusses the problem of determining phase during a transition from one cyclic state to another.
Dual Active Resonator for Dispersion Coefficient Measurement of Asphaltene Nano-Particles

Dispersion and diffusion of Asphaltene particles in <inline-formula> <tex-math notation="LaTeX">$n$ </tex-math></inline-formula>-Heptane is measured to investigate the solution characteristics of different concentrations in wide range of 0.000625–0.625 (%wt). Planar split ring resonator (SRR) is armed with active circuitry (active resonator) to enhance the quality factor over 3 K to achieve ultra-high resolution sensing and track minute variations in microfluidic tube. Parallel SRRs as dual active resonator are performing independently, both in sensing and resolution, at 1.03 GHz (<inline-formula> <tex-math notation="LaTeX">$f_{L}$ </tex-math></inline-formula>) and 1.149 GHz (<inline-formula> <tex-math notation="LaTeX">$f_{H}$ </tex-math></inline-formula>) as the sensing tool in non-contact mode to monitor the spread of model oil (short pulse) in <inline-formula> <tex-math notation="LaTeX">$n$ </tex-math></inline-formula>-Heptane (continuous flow). With the frequency shifts (<inline-formula> <tex-math notation="LaTeX">$\Delta f_{L}$ </tex-math></inline-formula>, <inline-formula> <tex-math notation="LaTeX">$\Delta f_{H}$ </tex-math></inline-formula>), average flow rate, and the inner diameter of the tube, the molecular diffusion coefficient, and then the dispersion coefficient can be rapidly derived according to two-window solution of Taylor-Aris dispersion analysis. Samples with higher concentration of Asphaltene are shown to have faster spread and larger dispersion in the flow. Dispersion coefficients of the samples cover the range of 5.2–<inline-formula> <tex-math notation="LaTeX">$7 \times 10^{-4}$ </tex-math></inline-formula> mm<sup>2</sup>/s in great agreement with conventional methods.
Cloning and characterization of a cluster of genes encoding polypeptides present in the insoluble fraction of the spore coat of Bacillus subtilis

The Bacillus subtilis spore coat is composed of at least 15 polypeptides plus an insoluble protein fraction arranged in three morphological layers. The insoluble fraction accounts for about 30% of the coat protein and is resistant to solubilization by a variety of reagents, implying extensive cross-linking. A dodecapeptide was purified from this fraction by formic acid hydrolysis and reverse-phase high-performance liquid chromatography. This peptide was sequenced, and a gene designated cotX was cloned by reverse genetics. The cotX gene encoding the dodecapeptide at its amino end was clustered with four other genes designated cotV, cotW, cotY, and cotZ. These genes were mapped to 107 degrees between thiB and metA on the B. subtilis chromosome. The deduced amino acid sequences of the cotY and cotZ genes are very similar. Both proteins are cysteine rich, and CotY antigen was present in spore coat extracts as disulfide cross-linked multimers. There was little CotX antigen in the spore coat soluble fraction, and deletion of this gene resulted in a 30% reduction in the spore coat insoluble fraction. Spores produced by strains with deletions of the cotX, cotYZ, or cotXYZ genes were heat and lysozyme resistant but readily clumped and responded more rapidly to germinants than did spores from the wild type. In electron micrographs, there was a less densely staining outer coat in spores produced by the cotX null mutant, and those produced by a strain with a deletion of the cotXYZ genes had an incomplete outer coat. These proteins, as part of the coat insoluble fraction, appear to be localized to the outer coat and influence spore hydrophobicity as well as the accessibility of germinants.
Development of Network Synchronization Predicts Language Abilities

Synchronization of oscillations among brain areas is understood to mediate network communication supporting cognition, perception, and language. How task-dependent synchronization during word production develops throughout childhood and adolescence, as well as how such network coherence is related to the development of language abilities, remains poorly understood. To address this, we recorded magnetoencephalography while 73 participants aged 4–18 years performed a verb generation task. Atlas-guided source reconstruction was performed, and phase synchronization among regions was calculated. Task-dependent increases in synchronization were observed in the theta, alpha, and beta frequency ranges, and network synchronization differences were observed between age groups. Task-dependent synchronization was strongest in the theta band, as were differences between age groups. Network topologies were calculated for brain regions associated with verb generation and were significantly associated with both age and language abilities. These findings establish the maturational trajectory of network synchronization underlying expressive language abilities throughout childhood and adolescence and provide the first evidence for an association between large-scale neurophysiological network synchronization and individual differences in the development of language abilities.