Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluating dimensionality reduction techniques for visual category recognition using rényi entropy

Visual category recognition is a difficult task of significant interest to the machine learning and vision community. One of the principal hurdles is the high dimensional feature space. This paper evaluates several linear and non-linear dimensionality reduction techniques. A novel evaluation metric, the rényi entropy of the inter-vector euclidean distance distribution, is introduced. This information theoretic measure judges the techniques on their preservation of structure in lower-dimensional sub-space. The popular dataset, Caltech-101 is utilized in the experiments. The results indicate that the techniques which preserve local neighborhood structure performed best amongst the techniques evaluated in this paper.
Inscribed Strategies: Exploring the Organizational Nature of Strategic Lock-in

An organization’s ability to act strategically under conditions of path dependence relies not only on the particular form of a strategic path but also on how this path is inscribed in an organization. To achieve a better understanding of this process, we shall introduce the concept of strategic path inscription and distinguish between mechanism inscription and pattern inscription. By referring to power, and formal and informal structures, the paper explores dimensions of the organizational context and its relation to strategic path inscription. The paper draws on an empirical study contrasting two established newspaper publishing organizations based in Germany. The comparative analysis of these cases reveals that in both organizations there are different forms of strategic pattern inscription but very similar forms of mechanism inscription. It is argued that the analysis of pattern inscription reveals much about the organizational nature of strategic lock-ins and, consequently, the range of variety that remains available to an organization after a specific path has emerged.
A systematic approach to the plain radiographic evaluation of the young adult hip.

Orthopaedic evaluation of hip pain in the young adult population has undergone a rapid evolution over the past decade1,2. This is in large part due to enhanced awareness of structural hip disorders, including developmental dysplasia of the hip and femoroacetabular impingement1-5. Surgical treatment for these disorders continues to be refined6-9, and our ability to identify patients along the spectrum of disease continues to improve10-15. Yet, despite our advances, obtaining an accurate diagnosis can remain challenging, especially in the setting of mild structural abnormalities. Therefore, radiographic examination is a critical component of the diagnostic evaluation and treatment decision-making process. It is essential that physicians have common and reliable radiographic views as well as parameters for plain radiographic assessment that can serve as a foundation for accurate diagnosis, disease classification, and surgical decision-making. Many different radiographic measurements have been described as indicators of structural disease. In particular, measurements such as the lateral center-edge angle of Wiberg16, the anterior center-edge angle of Lequesne17, the ac-etabular index of depth to width described by Heyman and Herndon18, the femoral head extrusion index19, and the Tonnis angle20 have been used as markers for acetabular dysplasia. Similarly, measurements of acetabular version21, the head-neck offset (initially described by Eijer)3,22, and the alpha angle19 have been used in the diagnosis of femoroacetabular impingement. Nevertheless, there is limited literature that provides comprehensive information regarding the details of radiographic evaluation in the young patient with hip symptoms. This paper summarizes the recommendations of the ANCHOR (Academic Network for Conservational Hip Outcomes Research) study group regarding the most important aspects of radiographic technique and image interpretation to evaluate the symptomatic, skeletally mature hip.
Mellan klassrum och scen - en studie av ensembleundervisning på gymnasieskolans estetiska program

Singing and playing instruments in Swedish secondary schools follow a long tradition, where playing in orchestras or singing in choirs are common historical examples of ensemble activities. In the last decades ensemble playing and teaching have undergone different changes, both in relation to musical practices at large, and with regard to repertoire, use of instruments, technical equipment and not least the philosophical and pedagogical ideas about music education. The aim of this thesis is to get a deeper knowledge about contemporary classroom ensemble in Swedish upper secondary schools. The research questions are: What does the object of learning look like in classroom ensemble? How are objects of learning in classroom ensemble legitimated? The theoretical framework is inspired by Foucauldian discourse analysis where the concept of discourse is used in an ecclectic way in order to grasp how ways of thinking about music, music education, pedagogy and didactics inform the music teachers and by that legitimizing different objects of learning. Data has been collected by focus group interviews, where four groups of music teachers participated, and by observing and interviewing three music teachers teaching classroom ensemble. Data has been analyzed following Foucault’s concepts of the event, the series, the regularity and the condition of possibility. In the analysis, two discourses are found to permeate the practice of classroom ensemble: (i) the discourse on artistry, which articulates objects with relevance for the performance (a concert, a show), where pupils try to simulate and implement an informal music practice and, (ii) the discourse on schooling, which articulates objects relating to schooling and education. The results show that the performances play a major role in the teaching of classroom ensemble, and as a result, what pupils learn is limited to what they are playing during those performances. This leads to questions about what the pupils learn by participating in such performances (Less)
What Affects Reintegration of Female Drug Users After Prison Release? Results of a European Follow-Up Study

The main objective of this follow-up study is to explore factors influencing the success or failure of women in reintegrating after their release from prison. Female drug users in five European cities were tracked after being released from prison. Out of 234 female prisoners contacted in prisons, 59 were included in the follow-up study. Structured questionnaires were given out and statistical group comparisons were conducted. The authors found that receiving preparation for release significantly supports a successful reintegration. On the other hand, living with a current drug user and initiating regular heroin use at an early age of less than 18 years are major barriers to successful reintegration.
Constrained discounted Markov decision processes and Hamiltonian cycles

Establishes new links between stochastic and discrete optimization. We consider the following three problems for discrete time Markov decision processes with finite states and action sets: (i) find an optimal deterministic policy for a discounted problem with constraints, (ii) find an optimal stationary policy for a weighted discounted problem with constraints, (iii) find an optimal deterministic policy for a weighted discounted problem with constraints. We show that the Hamiltonian cycle problem is a special case of each of these problems. Therefore problems (i-iii) are NP-hard in spite of the fact that a minor modification of problem (i) is polynomially solvable. We construct mathematical programs for each of these problems and formulate algorithms for the Hamiltonian cycle and traveling salesman problems that follow from the algorithms for problems (i-iii).
In Vitro Studies on the Antioxidant Property and Inhibition of α-Amylase, α-Glucosidase, and Angiotensin I-Converting Enzyme by Polyphenol-Rich Extracts from Cocoa (Theobroma cacao) Bean

Background. This study sought to investigate the antidiabetic and antihypertensive mechanisms of cocoa (Theobroma cacao) bean through inhibition of α-amylase, α-glucosidase, angiotensin-1 converting enzyme, and oxidative stress. Methodology. The total phenol and flavonoid contents of the water extractable phytochemicals from the powdered cocoa bean were determined and the effects of the extract on α-amylase, α-glucosidase, and angiotensin-1 converting enzyme activities were investigated in vitro. Furthermore, the radicals [1,1-diphenyl-2 picrylhydrazyl (DPPH), 2,2. -azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS), hydroxyl (OH), and nitric oxide (NO)] scavenging ability and ferric reducing antioxidant property of the extract were assessed. Results. The results revealed that the extract inhibited α-amylase (1.81 ± 0.22 mg/mL), α-glucosidase (1.84 ± 0.17 mg/mL), and angiotensin-1 converting enzyme (0.674 ± 0.06 mg/mL [lungs], 1.006 ± 0.08 mg/mL [heart]) activities in a dose-dependent manner and also showed dose-dependent radicals [DPPH (16.94 ± 1.34 mg/mL), NO (6.98 ± 0.886 mg/mL), OH (3.72 ± 0.26 mg/mL), and ABTS (15.7 ± 1.06 mmol/TEAC·g] scavenging ability. Conclusion. The inhibition of α-amylase, α-glucosidase, and angiotensin-1 converting enzyme activities by the cocoa bean extract could be part of the possible mechanism by which the extract could manage and/or prevent type-2 diabetes and hypertension.
Speech Duration and Dependencies in Initially Structured and Unstructured Task Groups

We examine whether speech durations and speech content vary by social structure in groups and the content of preceding speeches. When actors are structural equals in groups, an observable interaction order emerges from interaction processes. When we experimentally impose authority, skill, or sentiment structures, structural advantage is related to longer speech durations. When structures are combined such that an actor is advantaged in more than one social structure, then the actor engages in shorter speech durations, although dominance (as measured by perceived contributions to the group) remains high for the actor. In addition, the likelihood that an actor contributes a solution to a group problem or invites other contributions is highly dependent on whether the preceding speech included positive feedback. The expected interdependence between contributions and invitations to contribute was not evident in our data. Thus our research provides new insight on the sequential dependencies between speech acts in groups.
Training Married Couples in Listening Skills: Effects on Behavior, Perceptual Accuracy and Marital Adjustment.

This research is an evaluation of training in active listening skills as one part of a comprehensive marriage enrichment program. Nineteen couples were randomly assigned to three groups. Two groups used an identical program except that in one session the experimental group was taught active listening skills. The third group was assigned to a waiting list. Those trained in the skills became significantly more accurate in their perceptions of spouses' attitudes and feelings than those in the waiting list or the other treatment group. However, this greater accuracy was not found to have any significant effect on marital adjustment.
A cohort evaluation of clinical use and performance characteristics of Ambu® AuraGain™: A prospective observational study

Background and Aims: Ambu® AuraGain™ (AG) (Ambu, Ballerup, Denmark) is a supraglottic device which has a design facilitating its use as a conduit for intubation. We designed this prospective observational study to assess the ease of AG placement in paralysed patients, determine its position and alignment to the glottis and assess its utility as a conduit for intubation. Methods: One hundred patients, aged 18–60 years, American Society of Anesthesiologists physical status I–II, undergoing elective surgery under general anaesthesia were included in the study. The ease and number of attempts for successful insertion, ease of gastric tube insertion, leak pressures, fibre-optic grade of view, number of attempts and time for tracheal intubation, time for AG removal and complications were recorded. The mean, standard deviation (SD), interquartile range (IQR) and range were calculated. The upper limit of confidence interval for overall failure rate was calculated using Wilson's score method. Results: AG was successfully inserted in all patients. The mean (SD) time taken for insertion was 17.32 (8.48) s. The median [IQR] leak pressures were 24 [20–28] cm of H2O. Optimal laryngeal view for intubation was obtained in 68 patients. Eighty-eight patients could be intubated in the first attempt. Five patients could not be intubated. The overall failure rate of device was 9%. Conclusion: AMBU® AuraGain™ serves as an effective ventilating aid, but caution is suggested before using it as a conduit for endotracheal intubation.
Sensitivity of Cancer Cells to Plk1 Inhibitor GSK461364A Is Associated with Loss of p53 Function and Chromosome Instability

Polo-like kinases are a family of serine threonine kinases that are critical regulators of cell cycle progression and DNA damage response. Predictive biomarkers for the Plk1-selective inhibitor GSK461364A were identified by comparing the genomics and genetics of a panel of human cancer cell lines with their response to a drug washout followed by an outgrowth assay. In this assay, cell lines that have lost p53 expression or carry mutations in the TP53 gene tended to be more sensitive to GSK461364A. These more sensitive cell lines also had increased levels of chromosome instability, a characteristic associated with loss of p53 function. Further mechanistic studies showed that p53 wild-type (WT) and not mutant cells can activate a postmitotic tetraploidy checkpoint and arrest at pseudo-G1 state after GSK461364A treatment. RNA silencing of WT p53 increased the antiproliferative activity of GSK461364A. Furthermore, silencing of p53 or p21/CDKN1A weakened the tetraploidy checkpoint in cells that survived mitotic arrest and mitotic slippage. As many cancer therapies tend to be more effective in p53 WT patients, the higher sensitivity of p53-deficient tumors toward GSK461364A could potentially offer an opportunity to treat tumors that are refractory to other chemotherapies as well as early line therapy for these genotypes. Mol Cancer Ther; 9(7); 2079–89. ©2010 AACR.
Activity systems, information sharing and the development of organizational knowledge in two Finnish firms: an exploratory study using Activity Theory

Introduction.In this paper, we discuss the link between information sharing and organizational knowledge production in two very different organizations; a company that handles insurance claims and a small, entrepreneurial hi-tech company. We suggest that this link has not been adequately addressed by studies of information behaviour, though a number of recent papers have proposed that human information behaviour research should appropriate methods from workplace studies and computer-supported cooperative work to provide a richer account of organizational information and knowledge work. Method. Two case studies of sharing practices in Finnish firms were carried out. Analysis. The version of activity theory that has been developed by Engestrom and other Finnish researchers was used to analyse the data. This has provided highly specific accounts of information sharing as a constituent of the varied processes that contribute to the development of organizational knowledge. Results. The overall analysis has allowed us to explain how and why organizational information sharing happens in terms that go beyond the cognitive and descriptive accounts of our earlier studies. Conclusions. Information behaviour is a repertoire of actions and operations and judgements about timing and ethics that are brought into play across work cycles and routines. From this perspective, the duality of organizational knowledge becomes clear: it is both individual and collective judgements about how to behave, and the incremental outcome of these judgements, embedded in decisions that support the objects of activity systems.
Prophylactic effect of IL-10 gene transfer on induced autoimmune dacryoadenitis.

PURPOSE To evaluate the effect of viral IL-10 on the lacrimal gland immunopathologic response in the ocular surface disease, induced autoimmune dacryoadenitis. METHODS Disease was induced in rabbits by injecting inferior lacrimal glands with peripheral blood lymphocytes activated by 5 days of coculture with autologous acinar cells in a mixed-cell reaction. In the treated group, an adenoviral vector carrying the vIL-10 gene was concurrently injected with activated lymphocytes. Tears were collected periodically for quantitation of IL-10 by ELISA. Two weeks after disease induction, tear production, tear film breakup time, and rose bengal staining score were determined. Sectioned glands were immunostained for expression of CD4, CD8, rabbit thymic lymphocyte antigen (RTLA), CD18 and major histocompatibility complex class II. RESULTS The titer of vIL-10 in tears was at its maximum on day 3, started to decline by day 7, and was undetectable by day 14. In the diseased group, the tear production rate and tear film breakup time were significantly decreased, and rose bengal staining was significantly increased. Diseased glands had immune cell infiltrates containing CD4+, RTLA+, and CD18+ cells, and major histocompatibility complex class II expression was increased. These changes were significantly ameliorated by expression of vIL-10. CONCLUSIONS In vivo transduction of the lacrimal gland with AdvIL-10 resulted in the transient appearance of vIL-10 in tears. The presence of vIL-10 partially suppressed the appearance of Sjögren-syndrome-like features of reduced tear production, accelerated tear breakup, ocular surface disease, and immunopathologic response. Anti-inflammatory cytokine gene expression may offer a therapeutic modality for the treatment of autoimmune dacryoadenitis, once suitable vectors become available.
Affect dysregulation & disorders of the self

In 1994 Allan Schore published his groundbreaking book, Affect Regulation and the Origin of the Self, in which he integrated a large number of experimental and clinical studies from both the psychological and biological disciplines in order to construct an overarching model of social and emotional development. Since then he has expanded his regulation theory in more than two dozen articles and essays covering multiple disciplines, including neuroscience, psychiatry, psychoanalysis, developmental psychology, attachment, and trauma. Affect Dysregulation and Disorders of the Self contains writings on developmental affective neuroscience and developmental neuropsychiatry. It is absolutely essential reading for all clinicians, researchers, and general readers interested in normal and abnormal human development.
Molecular‐dynamics simulation of phenylalanine transfer RNA. I. Methods and general results

A 24‐ps molecular‐dynamics simulation of motions in yeast tRNAPhe has been completed. The overall structure of the molecule is well preserved, for the motions represent fluctuations about an average structure that is very much like the crystallographic structure. The four helical stems remain intact, the structures of the loop regions do not deteriorate, and even the base stacking in the single‐stranded amino acid acceptor terminus is maintained. With two exceptions, none of the sugar puckers is significantly changed. The unconstrained floppy motions of base A76 are responsible for the repuckering of ribose 76. The other sugar that repuckers is ribose, 46, and this is the result of a very small structural change in the center of the molecule that is also responsible for the breakage of one tertiary hydrogen bond. This change in local structure does not seriously distort the base‐stacking and intercalation patterns where the variable loop and the D‐stem interact.
Effects of High and Low Prior Knowledge on Construction of a Joint Problem Space

Abstract The participants were 4th-year medical students designing a clinical trial to test a new hypothetical anticancer drug. They worked with the computer simulation the Oncology Thinking Cap in facilitated groups that differed in terms of their prior knowledge. Both groups engaged in constructive activity and reached similar endpoints. The groups differed qualitatively in how they went about constructing and navigating the joint problem space. The high-prior-knowledge group used their knowledge to help them construct plans, evaluate their actions, and stay focused on the goals of the experimental design task. The low-prior-knowledge group searched through the data exhaustively and used them to generate their plans. They were unsystematic in their planning and interpretation. They used the computer representations in their reasoning and worked at mapping the connections between the representations. The computer scaffolding played an important role for both groups, but the facilitator played a greater role in the low-prior-knowledge group.
Decentralized multi-charger coordination for wireless rechargeable sensor networks

Wireless charging is a promising technology for provisioning dynamic power supply in wireless rechargeable sensor networks (WRSNs). The charging equipment can be carried by some mobile nodes to enhance the charging flexibility. With such mobile chargers (MCs), the charging process should simultaneously address the MC scheduling, the moving and charging time allocation, while saving the total energy consumption of MCs. However, the efficient solutions that jointly solve those challenges are generally lacking in the literature. First, we investigate the multi-MC coordination problem that minimizing the energy expenditure of MCs while guaranteeing the perpetual operation of WRSNs, and formulate this problem as a mixed-integer linear program (MILP). Second, to solve this problem efficiently, we propose a novel decentralized method which is based on Benders decomposition. The multi-MC coordination problem is then decomposed into a master problem (MP) and a slave problem (SP), with the MP for MC scheduling and the SP for MC moving and charging time allocation. The MP is being solved by the base station (BS), while the SP is further decomposed into several sub-SPs and being solved by the MCs in parallel. The BS and MCs coordinate themselves to decide an optimal charging strategy. The convergence of proposed method is analyzed theoretically. Simulation results demonstrate the effectiveness and scalability of the proposed method.
Phonological characteristics of young children who stutter

Reports of the prevalence of the co-occurrence of stuttering and disordered articulation/phonology are consistent in the general finding that young children who stutter are more likely to exhibit speech sound errors than children who do not stutter. The extant literature addressing studies of speech sound errors using traditional articulation and phonological process descriptions, which provide information concerning the specific types of errors exhibited by young children who stutter, is reviewed. In addition, some of the approaches that are presently available for treating children who exhibit both stuttering and disordered phonology are discussed.