Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of Advanced Chromium Steels with Respect to Microstructure and Structural Stability

The really promising way how to improve the creep resistance of chromium steels was found in the early 80 th and was based on increasing nitrogen content in the steel up to 0.07 %. Vanadium nitride precipitating especially on dislocations inside subgrains during creep exposure plays the decisive role in the excellent creep strength of modified 9%Cr-1%Mo steel of the P91 type. The beneficial effect of tungsten on solid solution strengthening as well as on the creep resistance was appreciated especially in Japan and steel P 92 has been developed. Nevertheless, high creep resistance of P 92 steel is not only the result of increased tungsten content but boron addition to steel P 92 has also the significant effect. It must be realized that the increasing of Mo and/or W content in the steel should be limited with respect to Laves phase precipitation (about 1%Mo or 2%W) with high coarsening rate and therefore limited effect on the precipitation strengthening. The precipitation strengthening of these steels is ruled by M 23 C 6 and especially by vanadium nitride. Further increasing of CRS is possible by raising nitrogen content.
Adapting support vector machines to predict translation initiation sites in the human genome

This study is concerned with predicting translation initiation sites (TIS) in the human genome that start with the nucleotide sequence ATG. This sequence occurs 104 million times in the entire genome. However, current estimates predict that there are only about 30,000 or so TIS in the human genome, giving an imbalance ratio of about 1:3500 for TIS ATG vs. non-TIS ATG sites. Algorithms that are designed using datasets that have low imbalance ratio may not be well suited to predict TIS at the genomic level. In this paper, we modified the SVM algorithm that can handle moderately high imbalance ratio. The F-measures for other approaches were: linear discriminant 0%, SVM with under-sampling 4.1%, SVM with over-sampling 8.2%, neural network 13.3%, decision tree 20%, our approach 44%. This shows how poorly standard approaches perform at the genomic level due to the high imbalance ratio. Our approach improves the performance significantly.
Improvements in Forehead Flap Design for Nasal Reconstruction

Joseph Carpue introduced us to the use of the forehead flap for nasal reconstruction in 1814 after he read an account of its use in India. The forehead flap was the first pedicled flap to be described in European literature and it set off an immediate search for similar flaps elsewhere on the body. In fact, this initial use of the forehead flap was so inspirational that it has been given credit for the rise of plastic surgery as a specialty. The forehead flap is well situated to replace missing nasal skin due to its excellent vascularity, close proximity, and similar histologic qualities. In fact, it is safe to say the forehead flap is the first choice for reconstruction of nasal defects larger than 2.0 cm in diameter. Over the last 180 years there has been considerable refinement in the under stage and standardization of forehead flap design. This short monograph is intended to provide refinements in forehead flap design which, in these authors' opinion, provide superior nasal reconstruction results while minimizing donor site morbidity. Some of these modifications are fairly subtle while others fundamentally affect the design of a forehead flap. Incorporating these modifications will advance the sophistication of the reconstructive surgeon and improve results.
A Parental Health Education Model of Children’s Food Consumption: Influence on Children’s Attitudes, Intention, and Consumption of Healthy and Unhealthy Foods

This study proposes that parental mediation of television advertising and parental guidance of food consumption differentially influence children’s attitude, intention, and behavior toward the consumption of healthy and unhealthy foods. Structural equation modeling based on a survey of 1,119 children aged 9–12 supported our model, revealing that parental education strategies influence children’s food consumption in a complex manner that is highly context-dependent. Parental guidance of food consumption enhanced children’s healthy food attitude and intention to consume, while reducing the intention to consume unhealthy food. However, parental mediation of television advertising influenced unhealthy food attitude to a greater extent than healthy food attitude. Implications for health promotion and education, as well as parents and policy makers are discussed.
Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats.

BACKGROUND In response to high salt intake, transcription factor hypoxia-inducible factor (HIF) 1α activates many antihypertensive genes, such as heme oxygenase 1 (HO-1) 1 and cyclooxygenase 2 (COX-2) in the renal medulla, which is an important molecular adaptation to promote extra sodium excretion. We recently showed that high salt inhibited the expression of HIF prolyl-hydroxylase 2 (PHD2), an enzyme that promotes the degradation of HIF-1α, thereby upregulating HIF-1α, and that high salt-induced inhibition in PHD2 and subsequent activation of HIF-1α in the renal medulla was blunted in Dahl salt-sensitive hypertensive rats. This study tested the hypothesis that silencing the PHD2 gene to increase HIF-1α levels in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats. METHODS PHD2 short hairpin RNA (shRNA) plasmids were transfected into the renal medulla in uninephrectomized Dahl S rats. Renal function and blood pressure were then measured. RESULTS PHD2 shRNA reduced PHD2 levels by >60% and significantly increased HIF-1α protein levels and the expression of HIF-1α target genes HO-1 and COX-2 by >3-fold in the renal medulla. Functionally, pressure natriuresis was remarkably enhanced, urinary sodium excretion was doubled after acute intravenous sodium loading, and chronic high salt-induced sodium retention was remarkably decreased, and as a result, salt-sensitive hypertension was significantly attenuated in PHD2 shRNA rats compared with control rats. CONCLUSIONS Impaired PHD2 response to high salt intake in the renal medulla may represent a novel mechanism for hypertension in Dahl S rats, and inhibition of PHD2 in the renal medulla could be a therapeutic approach for salt-sensitive hypertension.
Static detection of resource contention problems in server-side scripts

With modern multi-core architectures, web applications are usually configured to serve multiple requests simultaneously by spawning multiple instances. These instances may access the same external resources such as database tables and files. Such contentions may become severe during peak time, leading to violations of atomic business logic. In this paper, we propose a novel static analysis that detects atomicity violations of external operations for server side scripts. The analysis differs from traditional atomicity violation detection techniques by focusing on external resources instead of shared memory. It consists of three components. The first one is an interprocedural and path-sensitive resource identity analysis that determines whether multiple operations access the same external resource, which is critical to identifying contentions. The second component infers pairs of external operations that should be executed atomically. Finally, violations are detected by reasoning about serializability of interleaved atomic pairs. Experimental results show that the analysis is highly effective in detecting atomicity violations in real-world web apps.
Fluorescence Microscopy Visualization of Single-Walled Carbon Nanotubes Using Semiconductor Nanocrystals

Carbon nanotube (CNT) based electronic, optical, chemical, and biological devices are in dire need of simple optical microscopy solutions, which can be utilized to image and manipulate CNTs in solution state, many times in biologically relevant aqueous environments. Here, we demonstrate fluorescence visualization of single-walled carbon nanotubes (SWNT) in aqueous solutions using simple light microscopes. For this purpose, stable SWNT dispersions of sodium-dodecyl-sulfonate (SDS) were prepared and mixed with CdSe−ZnS core−shell nanocrystals (quantum-dots (QDs)) functionalized by mercaptoacetic acid. QDs arrange themselves on the sidewalls of SWNTs by virtue of electrostatic interaction between zinc ions in their shell and electronegative oxygen atoms/anions in the sulfonate group of the surfactant, embodying the fluorescence visualization of SWNTs. Transmitted brightfield, SEM, and TEM images also provide clear indication of SWNT sidewalls decorated with these QDs. This visualization technique will facili.
Micro and nano structuring and texturing of polymers using plasma processes: potential manufacturing applications

We review our recent work on the deterministic (top down) micro/nano structuring and stochastic (random) micro/nano texturing of polymeric materials for a variety of applications. We create polymeric microfludics/microsystems using plasma processing as well as 'smart' polymer surfaces with controlled wetting and optical properties. First, fabrication of polymeric micro-nanosystems and microfluidics using standard photolithography followed by plasma etching is proposed as an alternative method for polymer microfabrication. Second, plasma induced polymer nanoroughening (nanotexturing) is proposed as an extremely attractive methodology to control the wetting properties of polymers and create superhydrophilic or hydrophobic or robust superhydrophobic polymer surfaces. These surfaces may in addition possess controlled optical properties, such as antireflectance combined with good transmittance. Third, ordered spontaneously formed structures are created on plasma processed polymers. Potential applications are discussed.
The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population.

OBJECTIVES A missense SNP, C1858T, in PTPN22 has been identified as a genetic risk factor for rheumatoid arthritis (RA). Subsequent work has suggested that other variants in this gene, in particular a haplotype marked by the minor allele of rs3789604, are associated with RA in white North Americans independent of C1858T. We tested this hypothesis in an independent white Dutch study. METHODS A total of 667 RA patients and 286 controls were genotyped for 13 PTPN22 single nucleotide polymorphisms (SNPs) by allele-specific kinetic polymerase chain reaction. rs3789604 was genotyped in an additional 410 RA and 270 UA patients participating in the Leiden early arthritis inception cohort. We conducted single-marker and haplotype association tests. RESULTS The sole haplotype strongly associated with RA in our Dutch population carries the PTPN22 1858T allele. A second haplotype identical at all other SNPs tested except 1858 was not associated with disease. No significant association of the haplotype tagged by the 3' PTPN22 SNP, rs3789604, with RA susceptibility (P = 0.134) was observed in our sample set. CONCLUSION We conclude that C1858T is the sole PTPN22 variant predisposing to RA in our white Dutch sample set.
Micromoulding: process characteristics and product properties

Abstract Key aspects of the technology and challenges associated with the micromoulding process are discussed. The apparent shear and extensional viscosity behaviour of a polyacetal at high wall shear rates have been measured using inline capillary rheometry on a commercial micromoulding machine and a larger servoelectric injection moulding machine; the polymer behaved predictably at shear rates in excess of 106 s-1. Initial moulding trials indicated that a stepped plaque and 0·25 mm thick rectangular plaque mouldings filled in a satisfactory manner, but a thicker plaque cavity exhibited a jetting flow into the cavity. A data capture system capable of measuring multiple process dynamics at high sampling rates (up to 50 kHz per channel) allowed detailed process measurements taken during moulding of the stepped plaque moulding. Atomic force microscopy of the moulded products showed different surface finishes on each step of the stepped plaque moulding. Topography scans of the 0·25 mm thick rectangular plaque moulding showed that mould surface features with length scales of the order of a few micrometres were well replicated on the moulded product and the quality of the surface finish is dependent on the melt pressure during moulding.
The effect of nutrient enrichment on the growth, nucleic acid concentrations, and elemental stoichiometry of coral reef macroalgae

The growth rate hypothesis (GRH) links growth rates with organism elemental stoichiometry. Support for the GRH was found for many animal species, but less so for plants. This is the first study to test the GRH in macroalgae. Tropical coral reef macroalgae from three lineages, Caulerpa serrulata (Chlorophyta), Laurencia intricata (Rhodophyta), and Sargassum polyphyllum (Phaeophyceae) were grown enriched with nitrogen or phosphorous and under control conditions at Heron Island on the Great Barrier Reef, Australia. Growth rate, photosynthesis, nucleic acid composition, and elemental stoichiometry were measured. Nutrient enrichment had positive effects on photosynthetic rates and on investment in RNA. However, growth rate was not correlated with either photosynthetic rates or RNA content; thus, we did not find support for the GRH in tropical macroalgae. Macroalgae, especially L. intricata, accumulated P to very high levels (>0.6% of dry weight). The growth rate response to tissue P concentrations was unimodal. Above 0.21%, P accumulation had negative effects on growth. Nitrogen was not stored, but evidence of futile cycling was observed. The capacity to store large amounts of P is probably an adaptation to the low and patchy nutrient environment of the tropical oceans.
Evaluation of qualitative research.

It is necessary to subject published research to critical scrutiny, in order to evaluate the robustness of the findings. The criteria used in evaluation require to be appropriate for the research paradigm, i.e. quantitative or qualitative. Quantitative conceptualizations of reliability and validity are unsuitable for evaluation of qualitative research as they were not devised for this purpose. The use of quantitative criteria to evaluate qualitative research may create the impression that the latter is not academically rigorous. Evaluation criteria which are specific to qualitative research require identification and application, in order to provide a formalized and rigorous approach to critical appraisal. A formalized framework for evaluation will help to ensure that the contribution of qualitative studies, with specific reference to health services research, receives optimum recognition. The work of a number of writers is used in this paper to examine the features which distinguish qualitative research and the following are discussed: the need for researcher reflexivity; the use of the 'first person' in academic work; the context in which research takes place; the selection of research participants; the interpretation of participants' accounts; the active acknowledgement of 'lay' knowledge; researcher flexibility within the research process; the generalizability of findings. It is concluded that academically rigorous criteria, which are appropriate for evaluation of qualitative research, exist and are available for use by practitioners and researchers.
Ieee Transactions on Parallel and Distributed Systems 1 Resource-aware Application State Monitoring

—The increasing popularity of large-scale distributed applications in datacenters has led to the growing demand of distributed application state monitoring. These application state monitoring tasks often involve collecting values of various status attributes from a large number of nodes. One challenge in such large-scale application state monitoring is to organize nodes into a monitoring overlay that achieves monitoring scalability and cost-effectiveness at the same time. In this paper, we present REMO, a REsource-aware application state MOnitoring system, to address the challenge of monitoring overlay construction. REMO distinguishes itself from existing works in several key aspects. First, it jointly considers inter-task cost-sharing opportunities and node-level resource constraints. Furthermore, it explicitly models the per-message processing overhead which can be substantial but is often ignored by previous works. Second, REMO produces a forest of optimized monitoring trees through iterations of two phases. One phase explores cost-sharing opportunities between tasks, and the other refines the tree with resource-sensitive construction schemes. Finally, REMO also employs an adaptive algorithm that balances the benefits and costs of overlay adaptation. This is particularly useful for large systems with constantly changing monitoring tasks. Moreover, we enhance REMO in terms of both performance and applicability with a series of optimization and extension techniques. We perform extensive experiments including deploying REMO on a BlueGene/P rack running IBM's large-scale distributed streaming system-System S. Using REMO in the context of collecting over 200 monitoring tasks for an application deployed across 200 nodes results in a 35%-45% decrease in the percentage error of collected attributes compared to existing schemes.
Achievement of protein micro-crystallography at SPring-8 beamline BL32XU

A micro-focused X-ray beam with size ranging from 1 × 1 to 10 × 10 μm has been achieved at beamline BL32XU at SPring-8, Japan. Combining the available micro-beam with newly developed techniques has enabled efficient protein micro-crystallography.
BCDL: A high speed balanced DPL for FPGA with global precharge and no early evaluation

In this paper, we present BCDL (Balanced Cell-based Dual-rail Logic), a new counter-measure against Side Channel Attacks (SCA) on cryptoprocessors implementing symmetrical algorithms on FPGA. BCDL is a DPL (Dual-rail Precharge Logic), which aims at overcoming most of the usual vulnerabilities of such counter-measures, by using specific synchronization schemes, while maintaining a reasonable complexity. We compare our architecture in terms of complexity, performances and easiness to design with other DPLs (WDDL, IWDDL, MDPL, iMDPL, STTL, DRSL, SecLib). It is shown that BCDL can be optimized to achieve higher performances than any other DPLs (more than 1/2 times the nominal data rate) with an affordable complexity. Finally, we implement a BCDL AES on an FPGA and compare its robustness against DPA by using the number of Measurements To Disclosure (MTD) required to find the key with regards to unprotected AES. It is observed that the SCA on a BCDL implementation failed for 150,000 power consumption traces which represents a gain greater than 20 w.r. t. the unprotected version. Moreover the fault attack study has pointed out the natural resistance of BCDL against simple faults attacks.
Imputed Neighborhood Based Collaborative Filtering

Collaborative filtering (CF) is one of the most effective types of recommender systems. As data sparsity remains a significant challenge for CF, we consider basing predictions on imputed data, and find this often improves performance on very sparse rating data. In this paper, we propose two imputed neighborhood based collaborative filtering (INCF) algorithms: imputed nearest neighborhood CF (INN-CF) and imputed densest neighborhood CF (IDN-CF), each of which first imputes the user rating data using an imputation technique, before using a traditional Pearson correlation-based CF algorithm on the resulting imputed data of the most similar neighbors or the densest neighbors to make CF predictions for a specific user. We compared an extension of Bayesian multiple imputation (eBMI) and the mean imputation (MEI) in these INCF algorithms, with the commonly-used neighborhood based CF, Pearson correlation-based CF, as well as a densest neighborhood based CF. Our empirical results show that IDN-CF using eBMI significantly outperforms its rivals and takes less time to make its best predictions.
Normoxic cells remotely regulate the acid‐base balance of cells at the hypoxic core of connexin‐coupled tumor growths

ATP fuels the removal of metabolic end‐products, including H+ ions that profoundly modulate biological activities. Energetic resources in hypoxic tumor regions are constrained by low‐yielding glycolysis, and any means of reducing the cost of acid extrusion, without compromising pH homeostasis, would therefore be advantageous for cancer cells. Some cancers express connexin channels that allow solute exchange between cells, and we propose that, via this route, normoxic cells supply hypoxic neighbors with acid‐neutralizing HCO3_ ions. This hypothesis was tested by imaging cytoplasmic pH in spheroidal tissue growths of connexin43‐positive pancreatic cancer Colo357 cells during light‐controlled H+ uncaging at the hypoxic core. Cytoplasmic acid retention at the core was halved in the presence of CO2/HCO3−, but this process requires a restorative HCO3− flux. The effect of CO2/HCO3− was ablated by connexin43 inhibition or knockdown. In connexin‐decoupled spheroids, 4,4'‐diisothiocyano‐2,2'‐stilbenedisulfonic acid (DIDS), an inhibitor of HCO3− uptake, had no effect on cytoplasmic [H+]inthe H+‐uncaging region, indicating that DIDS‐sensitive transport is not an adequate pH‐regulatory strategy therein. With intact connexin‐coupling, acid retention at the core increased upon DIDS treatment, indicating that HCO3− ions are taken up actively by peripheral cells and then transmitted passively to cells at the hypoxic core. Thus, the energetic burden of pH regulation is offloaded from hypoxic cells onto metabolically altruistic normoxic neighbors. —Dovmark, T. H. , Hulikova, A. , Niederer, S. A. , Vaughan‐Jones, R. D. , Swietach, P. Normoxic cells remotely regulate the acid‐base balance of cells at the hypoxic core of connexin‐coupled tumor growths. FASEB J. 32,83‐96 (2018). www.fasebj. org
Dynamic superimposition of synthetic objects on rigid and simple-deformable real objects

A current challenge in augmented reality applications is the accurate superimposition of synthetic objects on real objects within the environment. This challenge is heightened when the real objects are in motion and/or are nonrigid. In this article, we present a robust method for realtime, optical superimposition of synthetic objects on dynamic rigid and simple-deformable real objects. Moreover, we illustrate this general method with the VRDA Tool, a medical education application related to the visualization of internal human knee joint anatomy on a real human knee.