Miracle-dz/UniFAR-FTUs huggingface dataset:
Specialist Physicians’ Attitudes and Practice Patterns Regarding Disclosure of Pre-referral Medical Errors

Objective:Our objective was to determine specialist physicians’ attitudes and practices regarding disclosure of pre-referral errors. Summary Background Data:Physicians are encouraged to disclose their own errors to patients. However, no clear professional norms exist regarding disclosure when physicians discover errors in diagnosis or treatment that occurred at other institutions before referral. Methods:We conducted semistructured interviews of cancer specialists from 2 National Cancer Institute-designated Cancer Centers. We purposively sampled specialists by discipline, sex, and experience-level who self-described a >50% reliance on external referrals (n = 30). Thematic analysis of verbatim interview transcripts was performed to determine physician attitudes regarding disclosure of pre-referral medical errors; whether and how physicians disclose these errors; and barriers to providing full disclosure. Results:Participants described their experiences identifying different types of pre-referral errors including errors of diagnosis, staging and treatment resulting in adverse events ranging from decreased quality of life to premature death. The majority of specialists expressed the belief that disclosure provided no benefit to patients, and might unnecessarily add to their anxiety about their diagnoses or prognoses. Specialists had varying practices of disclosure including none, non-verbal, partial, event-dependent, and full disclosure. They identified a number of barriers to disclosure, including medicolegal implications and damage to referral relationships, the profession's reputation, and to patient–physician relationships. Conclusions:Specialist physicians identify pre-referral errors but struggle with whether and how to provide disclosure, even when clinical circumstances force disclosure. Education- or communication-based interventions that overcome barriers to disclosing pre-referral errors warrant development.
Improving color correction across camera and illumination changes by contextual sample selection

In many tasks of machine vision applications, it is important that recorded colors remain constant, in the real world scene, even under changes of the illuminants and the cameras. Contrary to the human vision system, a machine vision system exhibits inadequate adaptability to the variation of lighting conditions. Automatic white bal- ance control available in commercial cameras is not sufficient to pro- vide reproducible color classification. We address this problem of color constancy on a large image database acquired with varying digi- tal cameras and lighting conditions. A device-independent color repre- sentation may be obtained by applying a chromatic adaptation transform, from a calibrated color checker pattern included in the field of view. Instead of using the standard Macbeth color checker, we suggest selecting judicious colors to design a customized pattern from contextual information. A comparative study demonstrates that this approach ensures a stronger constancy of the colors-of- interest before vision control thus enabling a wide variety of applica- tions.
DOES REAL INTEREST PARITY HOLD? EMPIRICAL EVIDENCE FROM ASIA

This paper presents some evidence on the real interest parity (RIP) hypothesis for six Asian countries vis-a-vis Japan. Testing RIP is carried out by examining the behaviour of ex ante real interest differentials, employing conventional and more sophisticated unit root tests. The results strongly reject the null hypothesis that the ex ante real interest differential follows a random walk in all cases when less conventional tests are employed. The results are interpreted to indicate that Asian markets have become highly integrated and that capital has become potentially highly mobile over the period under consideration. Genre Journal Article URL http://koara.lib. keio.ac. jp/xoonips/modules/xoonips/detail.php? koara_id=AA00260492-19960002- 0063
A low-power, wireless, 8-channel EEG monitoring headset

Micro- and nano-technology has enabled development of smaller and smarter wearable devices for medical and lifestyle related applications. In particular, recent advances in EEG monitoring technologies pave the way for wearable, wireless EEG monitoring devices. Here, a low-power wireless EEG sensor platform that measures 8-channels of EEG, is described. The platform is integrated into a wearable headset for ambulatory monitoring of EEG. While using standard EEG electrodes without conductive gel, a first evaluation shows the wireless headset is comparable to the reference system when looking at alpha wave discrimination. This device combines low-noise, and low-power functionality into an easy-to-use wireless headset, providing a first step towards a fully integrated, fully functional wearable wireless EEG monitoring system.
Gene Copy Number Estimation from Targeted Next-Generation Sequencing of Prostate Cancer Biopsies: Analytic Validation and Clinical Qualification

Purpose: Precise detection of copy number aberrations (CNA) from tumor biopsies is critically important to the treatment of metastatic prostate cancer. The use of targeted panel next-generation sequencing (NGS) is inexpensive, high throughput, and easily feasible, allowing single-nucleotide variant calls, but CNA estimation from this remains challenging. Experimental Design: We evaluated CNVkit for CNA identification from amplicon-based targeted NGS in a cohort of 110 fresh castration-resistant prostate cancer biopsies and used capture-based whole-exome sequencing (WES), array comparative genomic hybridization (aCGH), and FISH to explore the viability of this approach. Results: We showed that this method produced highly reproducible CNA results (r = 0.92), with the use of pooled germline DNA as a coverage reference supporting precise CNA estimation. CNA estimates from targeted NGS were comparable with WES (r = 0.86) and aCGH (r = 0.7); for key selected genes (BRCA2, MYC, PIK3CA, PTEN, and RB1), CNA estimation correlated well with WES (r = 0.91) and aCGH (r = 0.84) results. The frequency of CNAs in our population was comparable with that previously described (i.e., deep deletions: BRCA2 4.5%; RB1 8.2%; PTEN 15.5%; amplification: AR 45.5%; gain: MYC 31.8%). We also showed, utilizing FISH, that CNA estimation can be impacted by intratumor heterogeneity and demonstrated that tumor microdissection allows NGS to provide more precise CNA estimates. Conclusions: Targeted NGS and CNVkit-based analyses provide a robust, precise, high-throughput, and cost-effective method for CNA estimation for the delivery of more precise patient care. Clin Cancer Res; 23(20); 6070–7. ©2017 AACR.
Redox-modulated phenomena and radiation therapy: the central role of superoxide dismutases.

SIGNIFICANCE Ionizing radiation is a vital component in the oncologist's arsenal for the treatment of cancer. Approximately 50% of all cancer patients will receive some form of radiation therapy as part of their treatment regimen. DNA is considered the major cellular target of ionizing radiation and can be damaged directly by radiation or indirectly through reactive oxygen species (ROS) formed from the radiolysis of water, enzyme-mediated ROS production, and ROS resulting from altered aerobic metabolism. RECENT ADVANCES ROS are produced as a byproduct of oxygen metabolism, and superoxide dismutases (SODs) are the chief scavengers. ROS contribute to the radioresponsiveness of normal and tumor tissues, and SODs modulate the radioresponsiveness of tissues, thus affecting the efficacy of radiotherapy. CRITICAL ISSUES Despite its prevalent use, radiation therapy suffers from certain limitations that diminish its effectiveness, including tumor hypoxia and normal tissue damage. Oxygen is important for the stabilization of radiation-induced DNA damage, and tumor hypoxia dramatically decreases radiation efficacy. Therefore, auxiliary therapies are needed to increase the effectiveness of radiation therapy against tumor tissues while minimizing normal tissue injury. FUTURE DIRECTIONS Because of the importance of ROS in the response of normal and cancer tissues to ionizing radiation, methods that differentially modulate the ROS scavenging ability of cells may prove to be an important method to increase the radiation response in cancer tissues and simultaneously mitigate the damaging effects of ionizing radiation on normal tissues. Altering the expression or activity of SODs may prove valuable in maximizing the overall effectiveness of ionizing radiation.
Nephrogenic systemic fibrosis.

OBJECTIVE The purpose of this article is to discuss nephrogenic systemic fibrosis (NSF) in detail regarding its history, possible pathophysiology, clinical and pathologic presentations, diagnosis, and implications for the radiology community. CONCLUSION NSF is a potentially lethal disorder that occurs in patients with reduced kidney function. Current evidence suggests a strong association with gadolinium-based contrast agents--mostly used in MRI--in this patient group. This has urged the radiology community to emphasize careful screening for the presence of renal dysfunction among patients for whom gadolinium-enhanced MRI is contemplated. Appropriate selection of gadolinium-based contrast agent type, avoidance of nonstandard dosage, patient education, and informed consent have been recommended by authorities.
Thirteen-week study of toxicity of fiber-like multi-walled carbon nanotubes with whole-body inhalation exposure in rats

Abstract Cancer development due to fiber-like straight type of multi-walled carbon nanotubes (MWCNTs) has raised concerns for human safety because of its shape similar to asbestos. To set concentrations of MWCNT for a rat carcinogenicity study, we conducted a 13-week whole body inhalation study. F344 male and female rats, 6-week-old at the commencement of the study, were exposed by whole-body inhalation to MWCNT at concentrations of 0, 0.2, 1 and 5 mg/m3 with a generation and exposure system utilizing the cyclone sieve method. Measured concentrations in the exposure chambers were 0.20 ± 0.02, 1.01 ± 0.11 and 5.02 ± 0.25 mg/m3 for 13 weeks. The MMAD (GSD) of MWCNT were 1.4–1.6 μm (2.3–3.0), and mean width and length were 94.1–98.0 nm and 5.53–6.19 μm, respectively, for each target concentration. Lung weights were increased 1.2-fold with 1 mg/m3 and 1.3-fold with 5 mg/m3 in both sexes compared to the controls. In the bronchoalveolar lavage fluid (BALF) analyses, inflammatory parameters were increased concentration-dependently in both sexes from 0.2 mg/m3. Granulomatous changes in the lung were induced at 1 and 5 mg/m3 in females and even at 0.2 mg/m3 in males. Focal fibrosis of the alveolar wall was observed in both sexes at 1 mg/m3 or higher. Inflammatory infiltration in the visceral pleural and subpleural areas was induced only at 5 mg/m3. In conclusion, we determined 0.2 mg/m3 as the low-observed-adverse-effect level (LOAEL) for respiratory tract toxicity in the present inhalation exposure study of rats.
Modeling and Analysis of Bandwidth-Enhanced Multilayer 1-D EBG With Bandgap Aggregation for Power Noise Suppression

A circuit model of multilayer electromagnetic bandgap (EBG) structure with application on bandgap aggregation design is investigated in this paper. A design concept for bandgap aggregation is merging the lowest two bandgaps into an equivalent wide bandgap by narrowing central passband. This goal could be achieved by optimizing pitch and arrangement of power/ground vias. The theoretical circuit model which only focuses on cutoff frequencies is proposed for efficient bandgap prediction. The accuracy of the proposed model is validated by comparison with full-wave simulation and measurement results. By using the circuit model, mechanism of bandgap aggregation can be explained well, and the influence of structural parameters can also be studied easily. Furthermore, effect on limiting excitation of propagation modes by narrowing central passband is also validated for merging adjacent bandgaps. Test boards with unit cell size 2.03 mm × 3.94 mm are fabricated and measured to validate the design concepts. Both simulation and measurement show the wide bandgap in insertion loss results, which ranges from 1.27 GHz to above 10 GHz by merging even higher bandgaps.
Effect of β-3-Thienylalanine on Antibody Synthesis IV. Suppression of the Immune Response in Mice

The analogue of phenylalanine, β-3-thienylalanine (β-3-TA), inhibits the primary and secondary immune responses to sheep red blood cells in CBA mice fed with phenylalanine-free diet. The optimal dose of β-3-TA needed to obtain maximum immunosuppression with minimal toxicity is 250 mg per kg per day. The drug is maximally effective when administered for 7 days, beginning 2 days prior to primary immunization. With these experimental conditions, the antibody titers and the numbers of direct and indirect plaque-forming cells are greatly reduced during the primary and the secondary immune response.
Nootropic activity of lipid-based extract of Bacopa monniera Linn. compared with traditional preparation and extracts.

OBJECTIVES The aim was to design an alternative solvent-free extraction method using the hydrophilic lipid Gelucire (polyethylene glycol glycerides) for herbal extraction and to confirm the efficacy of extraction using biological screening. METHODS Bacopa monniera Linn. (BM) was selected for the study. Conventional methanolic extract (MEBM), Ayurvedic ghrita (AGBM) and lipid extracts (LEBM) were prepared and standardised by high-performance thin-layer chromatography (HPTLC). Nootropic activity in rats was evaluated using the two-trial Y-maze test and the anterograde amnesia induced by scopolamine (1 mg/kg i.p.) determined by the conditioned avoidance response. The extracts were administered daily at doses of 100, 200 and 400 mg/kg orally. At the end of the conditioned avoidance response test, brain monoamine levels were estimated by HPLC. KEY FINDINGS The LEBM, MEBM and AGBM contained 3.56%, 4.10% and 0.005% bacoside A, respectively. Significantly greater spatial recognition was observed with LEBM (P < 0.001 at 400 and 200 mg/kg) and MEBM (P < 0.001 at 400 mg/kg, P < 0.01 at 200 mg/kg) than AGBM. The conditioned avoidance response was significantly higher in the groups treated with high doses of LEBM and MEBM than AGBM. There were significant decreases in brain noradrenaline (P < 0.001) and 5-hydroxytryptamine (P < 0.01) levels and an increase in dopamine levels (P < 0.05) in the LEBM-treated groups compared with the stress control group. CONCLUSIONS The proposed LEBM is solvent free, does not have the shortcomings associated with conventional extraction, and had comparable nootropic activity to the MEBM.
Consumers and the economy, part II: Household debt and the weak U.S. recovery

The U.S. economic recovery has been weak, especially in employment growth. A microeconomic analysis of U.S. counties shows that this weakness is closely related to elevated levels of household debt accumulated during the housing boom. Counties where household debt grew moderately from 2002 to 2006 have seen a moderation of employment losses and a robust recovery in durable consumption and residential investment. By contrast, counties that experienced large increases in household debt during the boom have been mired in a severe recessionary environment even after the official end of the recession.
*Edgeworth Price Cycles: Evidence from the Toronto Retail Gasoline Market

In this article, I exploit a new station-level, twelve-hourly price dataset to examine the strong retail price cycles in the Toronto gasoline market. The cycles are visually similar to the theoretical Edgeworth Cycles of Maskin & Tirole [1988]: strongly asymmetric, tall, rapid, and highly synchronous across stations. I test a series of predictions made by the theory about how firm behaviors would differentially evolve over the path of a cycle. The evidence is consistent with the existence of Edgeworth Cycles and inconsistent with competing hypotheses. One finding is that smaller firms are more likely than larger firms to initiate rounds of price undercutting but the reverse is true for rounds of price increases. While the cycles are an interesting phenomenon for study in their own right, the evidence has important implications for understanding market power in both cycling and non-cycling gasoline markets.
Overcoming Consumer Biases in the Choice of Pricing Schemes: A Lab Experiment

This paper uses experimental data to investigate possible biases in consumers' choice of pricing schemes when their demand is perfectly inelastic but uncertain. I consider threepart pricing schemes (i.e. fixed fee, included units, extra-unit price). The analysis suggests a strong bias towards the pricing scheme with the number of included units equal to the expected demand. I interpret this bias as an “anchoring effect” of the expected demand on consumer decisions. Interestingly, subjects invest less effort into the choice problem when the opportunity cost of a mistake is higher. Still, the higher opportunity cost of a mistake helps subjects overcome the bias.
OrfX, a Nucleomodulin Required for Listeria monocytogenes Virulence

ABSTRACT Listeria monocytogenes is a bacterial pathogen causing severe foodborne infections in humans and animals. Listeria can enter into host cells and survive and multiply therein, due to an arsenal of virulence determinants encoded in different loci on the chromosome. Several key Listeria virulence genes are clustered in Listeria pathogenicity island 1. This important locus also contains orfX (lmo0206), a gene of unknown function. Here, we found that OrfX is a small, secreted protein whose expression is positively regulated by PrfA, the major transcriptional activator of Listeria virulence genes. We provide evidence that OrfX is a virulence factor that dampens the oxidative response of infected macrophages, which contributes to intracellular survival of bacteria. OrfX is targeted to the nucleus and interacts with the regulatory protein RybP. We show that in macrophages, the expression of OrfX decreases the level of RybP, which controls cellular infection. Collectively, these data reveal that Listeria targets RybP and evades macrophage oxidative stress for efficient infection. Altogether, OrfX is after LntA, the second virulence factor acting directly in the nucleus. IMPORTANCE Listeria monocytogenes is a model bacterium that has been successfully used over the last 30 years to refine our understanding of the molecular, cellular, and tissular mechanisms of microbial pathogenesis. The major virulence factors of pathogenic Listeria species are located on a single chromosomal locus. Here, we report that the last gene of this locus encodes a small secreted nucleomodulin, OrfX, that is required for bacterial survival within macrophages and in the infected host. This work demonstrates that the production of OrfX contributes to limiting the host innate immune response by dampening the oxidative response of macrophages. We also identify a target of OrfX, RybP, which is an essential pleiotropic regulatory protein of the cell, and uncover its role in host defense. Our data reinforce the view that the secretion of nucleomodulins is an important strategy used by microbial pathogens to promote infection. IMPORTANCE Listeria monocytogenes is a model bacterium that has been successfully used over the last 30 years to refine our understanding of the molecular, cellular, and tissular mechanisms of microbial pathogenesis. The major virulence factors of pathogenic Listeria species are located on a single chromosomal locus. Here, we report that the last gene of this locus encodes a small secreted nucleomodulin, OrfX, that is required for bacterial survival within macrophages and in the infected host. This work demonstrates that the production of OrfX contributes to limiting the host innate immune response by dampening the oxidative response of macrophages. We also identify a target of OrfX, RybP, which is an essential pleiotropic regulatory protein of the cell, and uncover its role in host defense. Our data reinforce the view that the secretion of nucleomodulins is an important strategy used by microbial pathogens to promote infection.
Economic development, decoupling and urban infrastructure : the role of innovation for an urban transition in Cape Town

This thesis investigates the case of the Cape Town Central City Provincial Government Revitalisation Initiative (CCPGRI) as a means to further understanding of socio-technical transitions. The departure point for this research is the recognition that the current economic growth and development trajectory is unsustainable. Despite this, deeply institutionalised frames of reference for decision-making reinforce and perpetuate the utilisation of (incumbent) sociotechnical systems which diminish finite resources and deteriorate eco-system services. The theoretical notion of decoupling, however, offers an alternative economic development paradigm. Decoupling has been identified, within this thesis, as the guiding framework through which adaption strategies should be carried out. This was indentified through a comprehensive literature review and an assessment of Cape Town‟s critical networked infrastructure. Networked infrastructure conveys flows of resources across vast urban spaces, in a linear configuration, thus conditioning resource flows and consumption. The case of Cape Town, however, illustrates that a linear configuration of infrastructure is both financially and environmentally unsustainable. Moreover, the case provides the empirical evidence for decoupling, reinforcing the argument for the adoption of the notion as an alternative development paradigm. Networked infrastructure has furthermore been identified as a socio-technical system, and therefore is considered as the component requiring a system transition and the subsequent intervention point for decoupling economic growth from resource consumption. From an implementation perspective, socio-technical system transitions, achieved through innovation, are the necessary component for realising sustainable urban development. It is argued that innovation, necessary for socio-technical system transitions, should be the product of sustainability-orientated innovation systems (SOIS‟s). SOIS‟s are implicitly linked to decoupling through the shared goal of enabling greater sustainability. The Cape Town CCPGRI has been extrapolated onto the multi-levelled perspective (MLP) model and is used to further understanding about how socio-technical system transitions are achieved. Findings indicate that socio-technical systems transitions are possible in urban areas that have multiple niche innovations developing simultaneously. Of significance is the presence of an intermediary, who is able to facilitate and manage the development of niche innovations emerging from SOIS‟s. It is therefore argued that high quality networking is critical for achieving socio-technical transitions which emerge from SOIS‟s.
Integrins as Therapeutic Targets: Successes and Cancers

Integrins are transmembrane receptors that are central to the biology of many human pathologies. Classically mediating cell-extracellular matrix and cell-cell interaction, and with an emerging role as local activators of TGFβ, they influence cancer, fibrosis, thrombosis and inflammation. Their ligand binding and some regulatory sites are extracellular and sensitive to pharmacological intervention, as proven by the clinical success of seven drugs targeting them. The six drugs on the market in 2016 generated revenues of some US$3.5 billion, mainly from inhibitors of α4-series integrins. In this review we examine the current developments in integrin therapeutics, especially in cancer, and comment on the health economic implications of these developments.