Miracle-dz/UniFAR-FTUs huggingface dataset:
A novel approach to semantic annotation based on multi-ontologies

Semantic annotation is very crucial to the semantic Web. Most traditional researches just commit the Web resources to a single ontology. However, many practical semantic annotation cases need multi-ontologies. For the sake of solving the semantic annotation problem based on multi-ontologies, one prevalent approach is extending current ontology or integrating multi-ontologies, but both methods are complex problems which have no good solutions till now. Another approach used distributed description logic to denote multi-ontologies and the subsumption relations between concepts in different ontology with a simple bridge rule, but this approach could not describe more complex relations between multi-ontologies. In this paper, a novel approach is proposed to deal with the problem, and we employ a bridge ontology to express the complex relationships between multi-ontologies. The bridge ontology is a peculiar ontology, which can be created and maintained easily, but effective in semantic annotation applications based on multi-ontologies. The approach has the characteristics of low-cost, scalability, robust in the Web circumstance, avoiding the unnecessary ontology extending and integration, and promoting ontology reuse. A semantic annotation framework and an algorithm are proposed As well.
Modelling of the recent crustal movements at the territory of Croatia, Slovenia and Bosnia and Herzegovina

The paper presents the results of determining vertical displacements of the Earth’s crust at the territory of Croatia, Slovenia, and Bosnia and Herzegovina on the basis of the data obtained in the process of establishing geometric levelling networks of the highest order of accuracy. These are the networks of the Austrian precise levelling, I. levelling of high accuracy and II. levelling of high accuracy that was established successively within the period of about 100 years (1874–1973). In accordance with the hypotheses made and the selected methodology for defining the displacements, a concrete numeric quantification of displacements has been obtained, the size and the direction of Earth’s crust displacements have been determined and their characteristics and empirical parameters of behaviour indicated. It is shown that bench mark displacements are of significant amount as related to the measurement accuracy of height differences in levelling networks and that long-wave and short-wave component of their variation can be noticed in correlation with the positional distribution of bench marks. The displacements have been modelled by means of so called grid models created by the combination of the regression modelling and the minimal curvature surface modelling. Thus, on the basis of modelled vertical displacement values the speed of uniform vertical crustal movements has been determined. In spite of the fact that a very simple methodology of displacement and movement determination has been used, that is based on the absolute heights of identical bench marks positioned in various epochs – networks, the obtained results present an adequate starting point for the selection and application of more sophisticated methodologies in determining and modelling of displacements in the forthcoming research, i.e. the starting point that enables interdisciplinary explanation of geodynamic processes leading to the changes in the shape and geometry of the Earth’s crust at the observed area.
Empowering the IoT Heterogeneous Wireless Networking with Software Defined Radio

In this paper, we present a Software Defined Radio (SDR) based platform that is able to efficiently support the heterogeneous wireless standards of the IoT. We enable the concurrent transmission and reception of multiple standards and channels, within the same radio band, utilizing a single workstation with open-source software and an SDR device. Both of the two most prevalent standards, the IEEE 802.11 & 802.15. 4, are fully implemented in software, and are able to simultaneously interact with real devices. The proposed platform can serve as the basis for any heterogeneous architecture, without the need for multiple transceivers and complex integration schemes, with unique flexibility and upgradability.
Identifying the key issues for measuring loyalty

In the past researchers have chosen to measure loyalty using purely behavioural or attitudinal measures or attitude-behaviour combinations. The authors recommend that both attitudinal and behavioural loyalty should be measured to gain an appreciation of the loyalty make-up of the firm's customer base. Knowing the proportion of each type of loyalty is important as customer reactions to marketing efforts will differ depending on the factors underlying consistent purchase behaviour.
Strategic Management in the Hospitality Industry

Table of Contents 1. Leadership, Strategy and the Value Adding Manager 2. The Coalignment Model 3. General Concepts in Scanning 4. Identifying Forces Driving Change 5. Scanning the Remote Environment 6. Scanning the Task Environment 7. Investing in Competitive Methods 8. Competitive Methods and Industry Performance 9. Developing, Maintaining and Enhancing Core Competencies 10. Implementation and Execution of Strategy-Achieving and Managing Coalignment Leadership: Behavioral Aspects of Strategy
Natural mRNA is required for directing Met-tRNA(f) binding to 40S ribosomal subunits in animal cells: involvement of Co-eIF-2A in natural mRNA-directed initiation complex formation.

Two protein factors, eIF-2 as well as a high molecular weight protein complex from reticulocyte ribosomal high-salt wash which we term Co-eIF-2, promote Met-tRNA(f) binding to 40S ribosomes. This binding is dependent on the presence of an AUG codon or natural mRNAs [Roy et al. (1984) Biochem. Biophys. Res. Commun. 122, 1418-1425]. Co-eIF-2 contains two component activities, Co-eIF-2A and Co-eIF-2C. Previously, we have purified an 80-kDa polypeptide containing Co-eIF-2A activity and showed that this polypeptide is a component of Co-eIF-2 and is responsible for Co-eIF-2A activity in Co-eIF-2 [Chakravarty et al. (1985) J. Biol. Chem. 260, 6945-6949]. We now report purification of a protein complex (subunits of Mr 180K, 110K, 65K, 63K, 53K, 50K, 43K, and 40K) containing Co-eIF-2C activity and devoid of Co-eIF-2A activity. In SDS-PAGE, the purified Co-eIF-2C preparation and an eIF-3 preparation (purified in Dr. A. Wahba's laboratory) separated into seven similar major polypeptides (Mr 110K, 65K, 63K, 53K, 50K, 43K, and 40K). The 50-kDa polypeptide in Co-eIF-2C was immunoreactive with a monoclonal antibody against eIF-4A (50 kDa). We have studied the roles of purified Co-eIF-2A and Co-eIF-2C activities in ternary and Met-tRNA(f). 40S ribosome complex formation. The results are as follows: (1) At low and presumably physiological factor concentration (30 nM), eIF-2 did not form detectable levels of ternary complex. Moreover, such complex formation was totally dependent on the presence of Co-eIF-2A and/or Co-eIF-2C. (ABSTRACT TRUNCATED AT 250 WORDS)
Signaling and Regulation Constitutive Aberrant Endogenous Interleukin-1 Facilitates In fl ammation and Growth in Human Melanoma

Interleukin (IL)-1–mediated inflammation is proposed to contribute to the development and progression of some cancers. IL-1 family member proteins are known to be expressed constitutively in many melanoma tumor cells, and we hypothesize that these support molecular pathways of inflammation and facilitate tumor growth. To investigate the expression of IL-1a and IL-1b in melanoma patients, and their association with disease progression, immunohistochemical staining was carried out on tissues from 170 patients including benign nevi, primary melanomas, and metastatic melanomas. IL-1b levels were low (or zero) in benign nevi and higher in primary and metastatic melanomas (P < 0.0001). IL-1awas expressed in about 73% of nevi and 55% of metastatic melanomas, with levels significantly higher in primary tumors (P < 0.0001); most (98%) primary melanoma samples were positive for IL-1a. In vitro studies with seven humanmelanoma cell lines showed that five cell lines expressed IL-1a and IL-1b proteins and mRNA. We identified for the first time several important downstream signaling pathways affected by endogenous IL-1, including reactive oxygen and nitrogen species, COX-2, and phosphorylated NF-kB inhibitor (IkB) and stress-activated protein kinase/c-jun-NH2-kinase; all of which were decreased by siRNA to IL1s. Downregulation of IL-1a, IL-1b, or MyD88 substantially increased p21 and p53 levels. Treatment with IL-1 receptor type I neutralizing antibody or IL-1 pathway–specific siRNAs led to growth arrest in IL-1–positive melanoma cells. Furthermore, blocking the IL-1 pathway increased autophagy in IL-1–positive melanoma cells. These results indicate that the endogenous IL-1 system is functional in most humanmelanoma and interrupting its signaling inhibits the growth of IL-1–positive melanoma cells. Mol Cancer Res; 1–14. 2011 AACR.
Prevention of secondary caries by silver diamine fluoride.

PURPOSE This study aimed to investigate the use of 38% silver diamine fluoride (SDF) as a treatment for preventing secondary caries in glass ionomer cement (GIC) and composite resin (CR) restorations. METHODS Six extracted human sound premolars were collected. Four cavities (4 × 2 × 2 mm(3) ) were prepared on each premolar and then allocated to the following restoration groups: group 1, SDF conditioning and GIC restoration; group 2, GIC restoration; group 3, SDF conditioning and CR restoration; and group 4, CR restoration. After thermal cycling and sterilisation, the teeth were soaked in a 5% sucrose solution containing Streptococcus mutans and Lactobacillus acidophilus for 28 days. Micro-computed tomography was used to study demineralisation. The outer lesion depth (OLD) and wall lesion depth (WLD) of the tooth-restoration interface were measured. The OLD and WLD were directly related to the extent of secondary caries. Two-way analysis of variance was used to analyse the effects of SDF conditioning and restorative materials on OLD. RESULTS The mean ± standard deviation OLD values were 156 ± 45 μm, 235 ± 33 μm, 153 ± 20 μm and 232 ± 24 μm for groups 1-4, respectively. The OLD was less in restorations with SDF conditioning (P < 0.001) than in those without SDF conditioning. No interaction effect on OLD was found between the restorative materials and SDF conditioning (P = 0.062). The WLD was detected only in groups 3 and 4. CLINICAL SIGNIFICANCE Conditioning with 38% SDF can increase resistance of GIC and CR restorations to secondary caries.
TITLE: Medical Management of Vestibular Disorders and Vestibular Rehabilitation SOURCE: Grand Rounds Presentation, UTMB, Dept. of Otolaryngology

"This material was prepared by resident physicians in partial fulfillment of educational requirements established for the Postgraduate Training Program of the UTMB Department of Otolaryngology/Head and Neck Surgery and was not intended for clinical use in its present form. It was prepared for the purpose of stimulating group discussion in a conference setting. No warranties, either express or implied, are made with respect to its accuracy, completeness, or timeliness. The material does not necessarily reflect the current or past opinions of members of the UTMB faculty and should not be used for purposes of diagnosis or treatment without consulting appropriate literature sources and informed professional opinion. "
The effect of different cement insertion techniques on the bone-cement interface.

Since the introduction of cemented total hip arthroplasty, the method of cement usage has evolved through several generations. These changes may have been responsible for an improvement in femoral component longevity. The nature of the bone-cement interface in first-generation cementing techniques has been described, but the bone-cement interface in more recent cementing techniques has not. This article describes the bone-cement interface after 2 different cementing techniques in a canine total hip arthroplasty model.
Integrated Antennas on HR Silicon for Single Chip Automotive Radar Applications

In this paper we will present our latest research results of integrated silicon antennas for automotive radar applications (f = 80 GHz). The design procedure as well as simulation and first measurement results will be given. Within this work two antenna designs, a 1-dimensional array (single line antenna) and a 2-dimensional antenna array (4 lines with 4 patches), will be shown. First measurement results are very promising for system application of an 80 GHz monolithically integrated automotive radar as well as for an integrated monitoring system. A simple monitoring system, using integrated MOTT Schottky diodes, is proposed as possible system application for the presented antennas.
Stabilized expression of mRNA is associated with mycobacterial resistance controlled by Nramp1

Control of innate resistance to the growth of mycobacteria is mediated by a gene termed Nramp1. Although the role of the protein product of Nramp1 in mediating resistance to mycobacterial growth is not known, the effect of the gene is pleiotropic and it has been suggested that the gene controls macrophage priming for activation. We have found that the functional capacity of macrophages from Mycobacterium bovis BCG-susceptible mice can be suppressed by corticosterone, while the function of macrophages from BCG-resistant mice remains unaffected. In this study, we show that corticosterone differentially affects the stability of mRNAs of several recombinant gamma interferon (rIFN-gamma)-induced genes. Treatment of macrophages from BCG-susceptible mice with corticosterone accelerates the decay of Nramp1 mRNA. The mRNA of IFN-gamma-induced genes of macrophages from BCG-resistant mice was more stable than the mRNA of macrophages from BCG-susceptible mice in the presence or absence of corticosterone. The results of this investigation suggest that Nramp1 acts by stabilizing the mRNA of genes associated with macrophage activation, thus accounting for the functional differences that have been attributed to these macrophage populations.
Induction of telomere-mediated chromosomal truncation and stability of truncated chromosomes in Arabidopsis thaliana.

Minichromosomes possess functional centromeres and telomeres and thus should be stably inherited. They offer an enormous opportunity to plant biotechnology as they have the potential to simultaneously transfer and stably express multiple genes. Segregating independently of host chromosomes, they provide a platform for accelerating plant breeding. Following a top-down approach, we truncated endogenous chromosomes in Arabidopsis thaliana by Agrobacterium-mediated transfer of T-DNA constructs containing telomere sequences. Blocks of A. thaliana telomeric repeats were inserted into a binary vector suitable for stable transformation. After transfer of these constructs into the natural tetraploid A. thaliana accession Wa-1, chromosome truncation by T-DNA-induced de novo formation of telomeres could be confirmed by DNA gel blot analysis, PCR (polymerase chain reaction), and fluorescence in situ hybridisation. The addition of new telomere repeats in this process could start alternatively from within the T-DNA-derived telomere repeats or from adjacent sequences close to the right border of the T-DNA. Truncated chromosomes were transmissible in sexual reproduction, but were inherited at rates lower than expected according to Mendelian rules.
Accounting and Public Accountability: A Macro and Micro Examination in Financial Accounting and Auditing

Accountability has its roots in accounting as both words’ etymology traces to the Latin word “accomptare” (to account). Financial accounting, as the field came to be known, has at its heart the rendering of an account of the financial affairs of an organization to interested parties who may have invested in, loaned money to or in other ways funded the organization. These parties are separate from the management of the organization and have limited powers to compel managers to reveal information. Hence, laws and regulations call on managers to account for their stewardship of the resources entrusted to them as well as to provide these third parties with information useful to determining whether they will invest, loan or provide more resources to the entity. Given this mandate to provide information about a financial nature, there have been increasing calls by third parties for accountants and accounting standards to be involved in a broader range of reporting such as environmental accounting and corporate social responsibility reporting. To aid in creating trustworthy financial accounts as well as other types of accounts, an entire profession of public accountants (also known as auditors) has grown to attest to the compliance of these accounts with generally accepted accounting principles so as to render a “true and fair account” of the organization’s finances or other appropriate standards. Thus, in this chapter we will outline the sources of public accountability in financial accounting practices and how public accounting (i.e., auditing) attempts to ensure that these financial accounts are trustworthy or worthy of belief by third parties who have relatively little ability to compel a further account. We also examine the call to expand this accounting and audit role beyond the financial. This review requires us to look at the “big picture” of the role of financial statements and other accountings in acts of public accountability as well as the micro roles of accountability practices and pressures on individuals involved in attesting to these accounts.
Organolead Halide Perovskite Nanocrystals: Branched Capping Ligands Control Crystal Size and Stability.

CH3 NH3 PbBr3 perovskite nanocrystals (PNCs) of different sizes (ca. 2.5-100 nm) with high photoluminescence (PL) quantum yield (QY; ca. 15-55 %) and product yield have been synthesized using the branched molecules, APTES and NH2 -POSS, as capping ligands. These ligands are sterically hindered, resulting in a uniform size of PNCs. The different capping effects resulting from branched versus straight-chain capping ligands were compared and a possible mechanism proposed to explain the dissolution-precipitation process, which affects the growth and aggregation of PNCs, and thereby their overall stability. Unlike conventional PNCs capped with straight-chain ligands, APTES-capped PNCs show high stability in protic solvents as a result of the strong steric hindrance and propensity for hydrolysis of APTES, which prevent such molecules from reaching and reacting with the core of PNCs.
Compact Triple-Band Waveguide Bandpass Filter Using Concentric Multiple Complementary Split Ring Resonators

This paper presents a compact tri-band waveguide bandpass filter using concentric multiple complementary split ring resonators (CSRRs). Two symmetrical concentric multiple CSRRs are placed on the transverse plane of a standard WR-90 rectangular waveguide at 8.41mm distance to achieve dual-pole, tri-band response. The proposed filter has been simulated using Ansoft High Frequency Simulation Software (version 14). Based on the simulated result the filter has been fabricated and tested. The measured result shows a dual-pole, tri-band, bandpass response with passbands at 8.04–8.2675GHz, 9.45–9.84925GHz and 11.35–12.005GHz, which is in good agreement with the simulated responses. The total length of the filter is 10mm, which makes it compact and light weight. An approximate equivalent circuit of the filter also has been provided.
R&D Investment, Market Structure, and Industry Growth

We study how alternative market structures influence market supply and R&D investment decisions of firms operating in dynamic imperfectly competitive environments. Firms can reduce their future production cost through R&D investment today, which is the engine of endogenous industry growth. Our framework enables us to identify key strategic ingredients in firms dynamic competitive behavior through analytical characterizations. These ingredients are a static market externality, stemming from the standard oligopolistic Cournot competition, a dynamic externality that arises due to knowledge spillovers, and a dynamic market externality that comes from the interaction of knowledge spillovers with future market oligopolistic competition that firms internalize while making decisions. We isolate the impact of each strategic ingredient by comparing four alternative market structures.
Pharmacologic Optimization of Protease Inhibitors and Nonnucleoside Reverse Transcriptase Inhibitors (POPIN)-A Randomized Controlled Trial of Therapeutic Drug Monitoring and Adherence Support

Summary: We evaluated the feasibility and effectiveness of therapeutic drug monitoring (TDM) and adherence support (collectively, AT) vs standard of care (SOC) in patients receiving HIV protease inhibitors (PIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) within a nurse-led clinic. Primary end points were failure to achieve viral load of <50 copies/mL at 24 weeks, viral rebound, or development of treatment limiting toxicity. One hundred twenty-two patients (AT 63 and SOC 59) were followed-up every 12 weeks, for a median of 72 weeks. No difference was observed between arms in risk of reaching a study end point or between groups of patients with abnormal vs "therapeutic" drug concentrations. Interindividual variabilities (coefficient of variation) were the following: efavirenz, 77.5%; nevirapine, 74.5%; lopinavir, 73.4%; nelfinavir, 83.7%; indinavir, 80.8%; saquinavir, 112.4%. Intraindividual variabilities (median coefficient of variation) were the following: NNRTIs, approximately 25%; PIs, 48.4%. Despite persistently abnormal results in 26 of patients in the AT arm (38%), dosage adjustment was only undertaken in 9 patients (35%). A significant proportion of patients had drug concentrations outside the therapeutic range. The Pharmacologic Optimization of PIs and NNRTIs (POPIN) study confirms that TDM trials are complex to interpret and statistically underpowered, with effectiveness better assessed through the clinical utility of a TDM result, whether normal or abnormal. Although TDM of PIs and NNRTIs may be useful in selected patients, routine and unselected use is not supported by current evidence.
Optimal sequencing of antiretroviral drug cocktails under uncertainty and irreversibility

This paper develops a real options approach to the optimal sequencing of antiretroviral drug cocktails for HIV/AIDS patients in resource-poor settings. The analysis focuses on the implications of endogenous resistance mutations in the virus that reduce or eliminate the effectiveness of individual drugs within a cocktail when lack of laboratory equipment prevents these from being identified. Using a model with two drug cocktails, we show that the first-line therapy should be introduced later than in the case without resistance mutations and that the second-line therapy should be introduced earlier. We go on to discuss implications for comparative cost-effectiveness analyses.
Effect of ownership structure on firm performance

In this study, I examine the relation between ownership structure and firm performance. The sample consists of 80 Dutch listed firms. Ownership structure is divided into inside ownership and outside ownership. Inside ownership is divided in family ownership and managerial ownership. The results show a significant positive relation for family ownership and firm performance, this indicates that family ownership does improve firm performance. Outside ownership is divided in corporate ownership, institutional ownership and governmental ownership. The results show a significant relation between governmental ownership and firm performance, this indicates that governmental ownership does improve firm performance.