Miracle-dz/UniFAR-FTUs huggingface dataset:
Pembaharuan Pendidikan Islam Konsep Pendidikan Tinggi Islam Menurut Pemikiran Fazlur Rahman

Fazlur Rahman idea of renewal Islamic college is lead to improvement of the current Islamic education. The final conclusion of this paper is (1). the formulation of thought the concept of Islamic higher education to be developed must be built on a solid paradigm spiritually, superior intellectually, and graceful morally with the Qur'an as a first reference and foremost. (2) offer a curriculum that are open to the studies of philosophy and social-science. (3) If the Islamic college in Indonesia is willing to follow the educational Fazlur Rahman thinking, motivation Indonesian Muslims to the development of science will be stronger, the dichotomy of science will be increasingly eroded. Abstrak Gagasan Fazlur Rahman tentang pembaharuan pendidkan tinggi Islam sangat berhubungan dengan peningkatan pendidikan Islam masa kini. Kesimpulan akhir dari makalah ini adalah (1) formulasi pemikiran tentang konsep pemikiran mengenai pendidikan tinggi Islam yang akan dikembangkan harus dibangun di atas paradigma spiritual yang solid, unggul secara intelektual, dan anggun secara moral sesuai dengan Al-Qur'an sebagai rujukan pertama dan terutama. (2) kurikulum yang terbuka untuk studi filsafat dan ilmu sosial. (3) Jika perguruan tinggi Islam di Indonesia bersedia mengikuti pemikiran pendidikan Fazlur Rahman, maka keinginan umat Islam Indonesia untuk pengembangan ilmu pengetahuan akan lebih kuat, dikotomi ilmu akan semakin terkikis.
Activation of c‐Jun amino‐terminal kinase by GDNF induces G2/M cell cycle delay linked with actin reorganization

It is well known that the cell cycle is controlled by several cyclin/cyclin‐dependent kinase (Cdk) complexes whose expression and phosphorylation states vary with orderly periodicity. During the cell cycle, activity of the cyclin/Cdk complexes can be regulated directly or indirectly by a number of molecules, including protein kinases and phosphatases, p53, and Cdk inhibitors. Here, we show that the addition of glial cell line‐derived neurotrophic factor (GDNF) induced G2/M cell cycle delay in human SK‐N‐MC neuroectodermal tumor cells that express RET tyrosine kinase, accompanying actin reorganization. Cell cycle delay at G2/M was characterized by accelerated and prolonged Cdc2 phosphorylation and stabilization of cyclin B1 and Wee1 kinase expression. Interestingly, we found that phosphorylation and/or expression of Cdc2, cyclinB1, and Wee1 was controlled by the Rac1/c‐Jun NH2‐terminal kinase (JNK) pathway. Immunohistochemical analysis suggested that the G2/M cell cycle delay may be necessary to prevent the mitotic progression of SK‐N‐MC cells with perturbed actin cytoskeletons.
Psychological Capital as Mediator in Relationship among Organizational Socialization, Knowledge Integration and Sharing

this study focuses on the role of psychological capital, within the relationship among organizational socialization, knowledge integration and knowledge sharing. We developed a model in which psychological capital mediated between organizational socialization, knowledge integration and knowledge sharing. Our sample comprised 189 employees from south of China. Our research results showed that psychological capital fully mediated between organizational socialization and knowledge sharing as well as knowledge integration. Implicating for the theory and practice of results are discussed, and future research directions offered.
Highly Scalable NEMS Relays With Stress-Tuned Switching Voltage Using Piezoelectric Buckling Actuators

This paper reports the design, fabrication, characterization, and scaling analysis of novel buckling-based nanoelectromechanical relays that use, for the first time, piezoelectric actuation. The generated stress from anchored piezoelectric films is employed to buckle a clamped-clamped beam to connect suspended source and drain terminals, while the residual stress in the beam is used to control the actuation voltage. This demonstration is the first of its kind to exploit residual stress to deliver a highly scalable switching mechanism that exhibits low actuation voltage (~1.8V), very fast switching (~80 ns), and uniquely achieves an equivalent electric body bias via mechanical methods. Finite-element analysis and analytical simulations show a linear dependence of the switching voltage on the residual stress, while the voltage versus stress tuning slope is reduced linearly with scaling the piezoelectric film thickness (-16.6 mV/MPa for 10-nm thick aluminum nitride film). A scaling analysis shows that millivolt switching is possible for aggressively miniaturized relays, which highlights the great impact this technology could have on demonstrating ultralow power digital circuits and memories.
Concept formation and its relation to word learning and use in the second year

ABSTRACT Developmental differences in object word learning and use were investigated. Two groups of infant speakers: Beginner (vocabularies under 50 words) and Advanced (vocabularies over 50 words), participated in a concept formation and word learning and generalization experiment. Results indicated that both speaker groups formed concepts of and learned words for the to-be-learned objects, and generalized these words. However, Advanced speakers learned more concepts and words, and engaged in broader generalization than Beginner speakers. The following variables did not account for these developmental differences: child age, object permanence development, maternal speech, child action on objects. These findings can be explained by developmental differences in both the number and kind of object concepts formed in the second year. Words were primarily acquired for object concepts by both speaker groups. However, Beginner speakers formed fewer concepts, thus having a less extensive conceptual base supporting word learning. This may account for their lower levels of vocabulary acquisition. Additionally, Beginner speakers appear to form prototype/exemplar-based object concepts, leading to limited word extension, while Advanced speakers form featurally based object concepts, leading to broader extension.
A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute

Purpose: The hazard of exposure to ionizing radiation is a serious public and military health concern that has justified substantial efforts to develop medically effective radiation countermeasure approaches, including radiation protectors, mitigators, and therapeutics. Although such efforts were initiated more than half a century ago, no safe and effective radiation countermeasure has been approved by the United States Food and Drug Administration (FDA) for the acute radiation syndrome. This situation has prompted intensified research among government laboratories, academic institutions, and pharmaceutical companies to identify a new generation of countermeasures. In this communication we discuss selected promising radiation countermeasures at advanced stages of development. Conclusion: Other than granulocyte colony-stimulating factor, which has an Emergency Use Investigational New Drug (IND) status, four countermeasures have FDA IND status and other promising countermeasures are in development. Here we review primarily the in vivo efficacy of selected countermeasures in animal models and clinical studies.
Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests.

PURPOSE To review information on performance characteristics for tests that are commonly used to identify acute and chronic hepatic injury. DATA SOURCES AND STUDY SELECTION A MEDLINE search was performed for key words related to hepatic tests, including quality specifications, aminotransferases, alkaline phosphatase, gamma-glutamyltransferase, bilirubin, albumin, ammonia, and viral markers. Abstracts were reviewed, and articles discussing performance of laboratory tests were selected for review. Additional articles were selected from the references. Guideline Preparation and Review: Drafts of the guidelines were posted on the Internet, presented at the AACC Annual Meeting in 1999, and reviewed by experts. Areas requiring further amplification or literature review were identified for further analysis. Specific recommendations were made based on analysis of published data and evaluated for strength of evidence and clinical impact. The drafts were also reviewed by the Practice Guidelines Committee of the American Association for the Study of Liver Diseases and approved by the committee and the Association's Council. RECOMMENDATIONS Although many specific recommendations are made in the guidelines, some summary recommendations are discussed here. Alanine aminotransferase is the most important test for recognition of acute and chronic hepatic injury. Performance goals should aim for total error of <10% at the upper reference limit to meet clinical needs in monitoring patients with chronic hepatic injury. Laboratories should have age-adjusted reference limits for enzymes in children, and gender-adjusted reference limits for aminotransferases, gamma-glutamyltransferase, and total bilirubin in adults. The international normalized ratio should not be the sole method for reporting results of prothrombin time in liver disease; additional research is needed to determine the reporting mechanism that best correlates with functional impairment. Harmonization is needed for alanine aminotransferase activity, and improved standardization for hepatitis C viral RNA measurements.
Kinetics of procalcitonin in cardiogenic shock and in septic shock. Preliminary data

Abstract Background: In cardiac acute patients, data on procalcitonin (PCT) are controversial and the clinical interpretation of absolute PCT values represents a major challenge since they may be influenced by several factors. No data are so far available on the dynamics of PCT levels in patients with cardiogenic shock. Aims: to evaluate the serum evolution of PCT during intensive cardiac care unit (ICCU) staying in a group of 24 patients with cardiogenic shock (CS) following ST-elevation myocardial infarction (STEMI) submitted to primary percutaneous intervention (PCI) with no laboratory or clinical sign of infection. Furthermore we assessed the kinetics of PCT in a series of 24 patients with septic shock. Results: In septic shock, no significant difference was detectable in PCT kinetics between survivors (R2 = 0.90; P = 0.051) and non-survivors (R2 = 0.63; P = 0.204). In cardiogenic shock, survivors exhibited a significant reduction in PCT values (R2 = 0.94; P = 0.032) while non survivors did not (R2 = 0.68; P = 0.178). Conclusions: differently from septic shock, cardiogenic shock following STEMI was associated with heterogeneous patterns of temporal PCT variations since only patients who survived exhibited a significant PCT reduction during ICCU stay. Our findings support the contention that the ‘dynamic’ approach may be more reliable that the static one especially in cardiogenic shock.
A Rit GTPase-p38 Mitogen-Activated Protein Kinase Survival Pathway Confers Resistance to Cellular Stress

ABSTRACT Cells mobilize diverse signaling cascades to protect against stress-mediated injury. Ras family GTPases play a pivotal role in cell fate determination, serving as molecular switches to control the integration of multiple signaling pathways. p38 mitogen-activated protein kinase (MAPK) signaling serves as a critical fulcrum in this process, regulating networks that stimulate cellular apoptosis but also have the capacity to promote cell survival. However, relatively little is known concerning this functional dichotomy, particularly the regulation of p38-dependent survival pathways. Here, we demonstrate that the Rit GTPase promotes cell survival by directing an unexpected p38 MAPK-dependent AKT survival pathway. Following stress exposure, Rit small hairpin RNA interference (shRNAi)-treated cells display increased apoptosis and selective disruption of p38 MAPK signaling, while expression of constitutively activated Rit promotes p38-AKT-dependent cell survival. Rit, but not Ras or Rap GTPases, can associate with, and is critical for, stress-mediated activation of the scaffolded p38-MK2-HSP27-AKT prosurvival signaling complex. Together, our studies establish Rit as a central regulator of a p38 MAPK-dependent signaling cascade that functions as a critical cellular survival mechanism in response to stress.
Evaluation of pseudo adaptive XY routing using an object oriented model for NOC

In this paper we propose a pseudo adaptive routing which is an extension of classic XY routing. We consider mesh topology for evaluating proposed routing. Our switches use pseudo adaptive XY routing algorithm. The load in the center of a network in ordinary XY routing is much higher rather than total average. This extra load on the center of mesh can cause spot hot. The main objective of our routing algorithm is to distribute network load. One of the advantages of distributing network load is balanced temperature on the mesh. Our routing algorithm has two deterministic and adaptive modes that status of neighbors of each switch is used to decide on which mode must be selected. Packets are routed with classic XY routing (deterministic mode), when congestion in the network is low. When congestion is high, packets are routed through less congested route adaptively (adaptive mode). We developed a NOC environment using SystemC and applied two multimedia applications and a random traffic to proposed routing and compared with classic XY routing. Experimental results show better latency while average load is unchanged.
The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis

Linear ubiquitination is a key posttranslational modification that regulates immune signaling and cell death pathways, notably tumor necrosis factor receptor 1 (TNFR1) signaling. The only known enzyme complex capable of forming linear ubiquitin chains under native conditions to date is the linear ubiquitin chain assembly complex, of which the catalytic core component is heme‐oxidized iron regulatory protein 2 ubiquitin ligase‐1–interacting protein (HOIP). To understand the underlying mechanisms of maintenance of liver homeostasis and the role of linear ubiquitination specifically in liver parenchymal cells, we investigated the physiological role of HOIP in the liver parenchyma. To do so, we created mice harboring liver parenchymal cell–specific deletion of HOIP (HoipΔhep mice) by crossing Hoip‐floxed mice with albumin–Cre mice. HOIP deficiency in liver parenchymal cells triggered tumorigenesis at 18 months of age preceded by spontaneous hepatocyte apoptosis and liver inflammation within the first month of life. In line with the emergence of inflammation, HoipΔhep mice displayed enhanced liver regeneration and DNA damage. In addition, consistent with increased apoptosis, HOIP‐deficient hepatocytes showed enhanced caspase activation and endogenous formation of a death‐inducing signaling complex which activated caspase‐8. Unexpectedly, exacerbated caspase activation and apoptosis were not dependent on TNFR1, whereas ensuing liver inflammation and tumorigenesis were promoted by TNFR1 signaling. Conclusion: The linear ubiquitin chain assembly complex serves as a previously undescribed tumor suppressor in the liver, restraining TNFR1‐independent apoptosis in hepatocytes which, in its absence, is causative of TNFR1‐mediated inflammation, resulting in hepatocarcinogenesis. (Hepatology 2017;65:1963‐1978).
Reuse of mathematical problems and answers with e-learning system

For a class of “Exercises in Mathematics”, handouts which consist of mathematical problems from basic to advanced exercises are prepared and distributed every week. In the class, a teacher demonstrates the problem solving process of a sample basic problem with some comments on the crucial points. After his demonstration, students try to solve problems on the handouts. However, many students make logical mistakes which can be avoided easily if they understand the demonstration. In this paper, in order to increase the opportunities of making sensitive for the logical thinking in mathematics, we propose a method of reusing these handouts and answers with an e-Learning system.
IMMUNOPATHOLOGY AND INFECTIOUS DISEASES LAG 3 Expression in Active Mycobacterium tuberculosis Infections

From the Divisions of Bacteriology* and Microbiology,x Tulane National Primate Research Center, Covington, Louisiana; the Biomedical Sciences Graduate Student Program,y New Orleans, Louisiana; the National Institute of Respiratory Diseases,z Mexico City, Mexico; the Training in Lung Molecular and Cell Pathobiology Program,{ New Orleans, Louisiana; the Department of Molecular Microbiology and Immunology,k Washington University of St. Louis, St. Louis, Missouri; and the Department of Microbiology and Immunology,** Tulane University School of Medicine, New Orleans, Louisiana
Polymeric micelles for drug delivery

Polymeric micelles have been the subject of many studies in the field of drug delivery for the past two decades. The interest has specifically been focused on the potential application of polymeric micelles in three major areas in drug delivery: drug solubilisation, controlled drug release and drug targeting. In this context, polymeric micelles consisting of poly(ethylene oxide)-b-poly(propylene oxide), poly(ethylene oxide)-b-poly(ester)s and poly(ethylene oxide)-b-poly(amino acid)s have shown a great promise and are in the front line of development for various applications. The purpose of this manuscript is to provide an update on the current status of polymeric micelles for each application and highlight important parameters that may lead to the development of successful polymeric micellar systems for individual delivery requirements.
Portfolio control using the linear utility and differntiable trading strategies

Two approaches to portfolio selection using the linear utility of terminal wealth are proposed. The trading strategies are constrained to be differentiable and thus of finite variation. The linear utility is extended to include a quadratic penalty on the rate of change of the number of shares held in the risky asset. This removes the risk neutrality associated with the linear utility and portfolios with a certain risk aversion are obtained. The optimization tasks are formulated as control problems and solved explicitly using the method of dynamic programming
A DPA attack on RSA in CRT mode

RSA is the dominant public key cryptographic algorithm, and used in an increasing number of smart card applications. Modern smart cards include dedicated cryptographic processors to speed up processing time and can generally perform 1024 bit RSA operations in less than a second. Typical applications are in the payment and identification area, where public key cryptography can provide strong authentication combined with flexible key management. Transaction duration is generally an important aspect as this easily becomes a bottleneck for successful deployment.
LINEARITY ENHANCEMENT OF OPERATIONAL TRANSCONDUCTANCE AMPLIFIER USING SOURCE DEGENERATION

The signal to noise ratio and resolution of an analog to digital converter is governed by the linearity constraints of the basic building block, which is the Operational Transconductance Amplifier (OTA). The OTA design is based on MOS transistors that are inherently non linear and lead to performance deterioration. To overcome the non-linearities imposed by the OTA a resistive source degeneration technique is proposed. The use of linearization techniques leads to a tradeoff between transconductance and gain of the amplifier. The proposed Source Degenerated OTA (SDOTA) achieves Third order Intermodulation (IM3) of -62dB at a high frequency range of 70 MHz with an effective Transconductance of 655.8 µA/V. The SDOTA offers a gain of 14dB at a Unity Gain Frequency of 4.7 GHz and is implemented in 180nm CMOS technology.
Mutational analysis of the N-ras,p53,p16INK4a ,CDK4, and MC1R genes in human congenital melanocytic naevi

Eighteen human congenital melanocytic naevi (CMN) from 17 patients were screened for activating point mutations in the oncogenesN-ras andCDK4 and for sequence variants in the MC1R gene by combined RFLP-PCR/SSCP analysis. In addition, all lesions were screened for deletions and point mutations in the tumour suppressor genesp53 andp16INK4a (CDKN2A) by combined multiplex PCR/SSCP analysis. Positive screening data were specified by sequencing of the corresponding PCR product. Activating point mutations in theN-ras gene (nine CAA (Gln) to AAA (Lys) transversions and one CAA (Gln) to CGA (Arg) transition at codon 61) were detected at high frequency (56%). Furthermore, three missense mutations (V92M) and two silent mutations (CGA (Arg) to CGG (Arg), codon 213, exon 6) were found in theMC1R andp53 genes, respectively. No mutations were found in p16 orCDK4. The activatedN-ras oncogene, which is also found in human cutaneous melanomas, may constitute a potential risk factor for melanoma formation within CMN.
Design of Hybridized Wireless Sensor Network using K-Means Clustering and Genetic Algorithm

Prolonging the network lifetime in wireless sensor networks (WSNs), Clustering has been recognized has one of the significant methods in achieving this, It entails grouping of sensor nodes into clusters and electing cluster heads (CHs) for all the clusters. CH’s accept data from relevant cluster’s nodes and forward the aggregate data to base station. A main challenge in WSNs is the selection of appropriate cluster heads. This work proposes a system that is efficient, scalable and load balanced. The proposed scheme combines two known algorithms namely k-means clustering and genetic algorithms based on the weaknesses identified in the two. The simulated data is obtained through the enhancement of clustering by the cluster head (base station) that helps in locating the nearest node that is important in the data transfer instead of transferring to a node that is not necessary, thereby wasting time and resources. The obtained simulation results indicate that this approach is efficient and last longer in elongating the battery life time than the conventional method by 60%.