Miracle-dz/UniFAR-FTUs huggingface dataset:
The Research on Regularity of Residual Stress Distribution of Engine Crankshaft Fillet Rolling

The paper sets up the Finite Element Model on the basis of crankshaft fillet rolling experiment and its mechanism. And then the paper shows the distribution of the residual stress in different depths of rolled crankshaft fillet through numerical simulation. It is found that the fatigue strength can greatly be produced by the method of the engine crankshaft fillet rolling in most of fillet areas; Simultaneously, two strips of tensile stress which is related to reduce the crankshaft fatigue strength will be generated in the peripheries. The tensile stress strips only emerge in the surface layer of the fillet, and then mainly disappear in the depths of 0.4mm below the surface layer. The paper concludes that the main reason of strips of tensile stress lies on the transition between the deformed region and the non-deformed reformed region after trolley wheel pressure is imposed on through a further research.
Interactive public ambient displays: transitioning from implicit to explicit, public to personal, interaction with multiple users

We develop design principles and an interaction framework for sharable, interactive public ambient displays that support the transition from implicit to explicit interaction with both public and personal information. A prototype system implementation that embodies these design principles is described. We use novel display and interaction techniques such as simple hand gestures and touch screen input for explicit interaction and contextual body orientation and position cues for implicit interaction. Techniques are presented for subtle notification, self-revealing help, privacy controls, and shared use by multiple people each in their own context. Initial user feedback is also presented, and future directions discussed.
Multi-set DHT for interval queries on dynamic data

Scalability is a fundamental problem for information syste ms when the amount of managed data increases. Peer to Peer systems are usually used to solve scalability proble ms as centralized approaches do not scale without large dedicated infrastructure. But most current Peer to Peer sys tems do not take into account that indexed data can be dynamic and change their values very often. Thus, we propose theMulti-set approach, which aims to find the best trade-off between DHT-based network and total replication . This approach is built over classical DHT Peer to Peer system. It can improve most of pure DHT Peer to Peer system by t aking into account the dynamism of resources. Evaluation is done by modeling, simulation and experimenta tion on PlanetLab. This approach is more efficient than DHT Peer to Peer system and total replication whichever the d ynamism of resources is.
Significant similarity and dissimilarity in homologous proteins.

Common practice emphasizes significant sequence similarities between different members of protein families. These similarities presumably reflect on evolutionary conservation of structurally and functionally essential residues. The nonconserved regions, on the other hand, may be either selectively neutral or differentiated. We propose several distributional sequence statistics (e.g., clustering of charged residues, compositional biases, and repetitive patterns) as indicators of differentiation events. These ideas are illustrated with various examples, including comparisons among G protein-coupled receptors, herpesvirus proteins, and GTPase-activating proteins.
Evolutionary crossroads in developmental biology: amphioxus

The phylogenetic position of amphioxus, together with its relatively simple and evolutionarily conserved morphology and genome structure, has led to its use as a model for studies of vertebrate evolution. In particular, the recent development of technical approaches, as well as access to the complete amphioxus genome sequence, has provided the community with tools with which to study the invertebrate-chordate to vertebrate transition. Here, we present this animal model, discussing its life cycle, the model species studied and the experimental techniques that it is amenable to. We also summarize the major findings made using amphioxus that have informed us about the evolution of vertebrate traits.
Experimental study of the through-thickness strength of laminated composites

﻿ Complicated structures made of fibre reinforced laminates will suffer the failure of delamination which is the main through-thickness failure mode and is usually caused by the combined through-thickness stress state. Three tests, namely the oblique test, the waisted C-specimen test and the notched beam test, have been developed to reveal the failure activities under the combined stress state of in-plane normal stress, through-thickness normal stress and interlaminar shear, and, as a part of the big project, to establish a 3-D failure map in the coordinates of the three stress components. All tests have been analyzed either numerically by FEM or experimentally by Moire interferometry technique. The experimental results have shown that the failure behaviours of laminates are far more complicated than and very different from the traditional metallic materials which can usually be described by phenomenological failure criteria. The phenomenological criteria attempt has been tried and further confirmed that a full experimental understanding is the most important. Moreover, fractographic analysis by SEM has also been conducted to support the test results. Finally the Weibull statistics method has been used to treat the stress gradient effect in the different test geometries while establishing the failure map. It has proved to be a very efficient instrument.
Evaluation of multimodal medical image registration based on Particle Filter

This paper presents a performance evaluation of a new multimodal image registration algorithm which is based on Bayesian estimation theory, specifically on Particle Filters. The results point to an efficient, easy to implement and robust to noise algorithm. The registration method showed good performance when using partial data, and it was compared with an algorithm based on maximization of mutual information and a Hyperplanes optimization method. Finally, we showed that the algorithm may be parallelizable, so that it is possible to reduce the computation time for image registration.
Motion and Color Analysis for Animat Perception

We propose novel gaze control algorithms for active perception in mobile autonomous agents with directable, foveated vision sensors. Our agents are realistic artificial animals, or animals, situated in physics-based virtual worlds. Their active perception systems continuously analyze photorealistic retinal image streams to glean information useful for controlling the animal`s eyes and body. The vision system computes optical flow and segments moving targets in the low-resolution visual periphery. It then matches segmented targets against mental models of colored objects of interest. The eyes saccade to increase acuity by foveating objects, The resulting sensorimotor control loop supports complex behaviors, such as predation.
Sexual, marital, and general life functioning in couples coping with colorectal cancer: a dyadic study across time

This study evaluated the following: (a) levels of sexual, marital, and general life functioning for both patients and partners; (b) interdependence between both members of the couple; and (c) longitudinal change in sexual, marital, and general life functioning and longitudinal stress‐spillover effects in these three domains from a dyadic perspective.
mTOR inhibitors sensitize thyroid cancer cells to cytotoxic effect of vemurafenib

Treatment options for advanced metastatic thyroid cancer patients are limited. Vemurafenib, a BRAFV600E inhibitor, has shown promise in clinical trials although cellular resistance occurs. Combination therapy that includes BRAFV600E inhibition and avoids resistance is a clinical need. We used an in vitro model to examine combination treatment with vemurafenib and mammalian target of rapamycin (mTOR) inhibitors, metformin and rapamycin. Cellular viability and apoptosis were analyzed in thyroid cell lines by trypan blue exclusion and TUNEL assays. Combination of vemurafenib and metformin decreased cell viability and increased apoptosis in both BCPAP papillary thyroid cancer cells and 8505c anaplastic thyroid cancer cells. This combination was also found to be active in vemurafenib-resistant BCPAP cells. Changes in expression of signaling molecules such as decreased mTOR expression in BCPAP and enhanced inhibition of phospho-MAPK in resistant BCPAP and 8505c were observed. The second combination of vemurafenib and rapamycin amplified cell death in BCPAP cells. We conclude that combination of BRAFV600E and mTOR inhibition forms the basis of a treatment regimen that should be further investigated in in vivo model systems. Metformin or rapamycin adjuvant treatment may provide clinical benefits with minimal side effects to BRAFV600E-positive advanced thyroid cancer patients treated with vemurafenib.
Diagnostic Value of sTREM-1 in Bronchoalveolar Lavage Fluid in ICU Patients With Bacterial Lung Infections: A Bivariate Meta-Analysis

Background The serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is a useful biomarker in differentiating bacterial infections from others. However, the diagnostic value of sTREM-1 in bronchoalveolar lavage fluid (BALF) in lung infections has not been well established. We performed a meta-analysis to assess the accuracy of sTREM-1 in BALF for diagnosis of bacterial lung infections in intensive care unit (ICU) patients. Methods We searched PUBMED, EMBASE and Web of Knowledge (from January 1966 to October 2012) databases for relevant studies that reported diagnostic accuracy data of BALF sTREM-1 in the diagnosis of bacterial lung infections in ICU patients. Pooled sensitivity, specificity, and positive and negative likelihood ratios were calculated by a bivariate regression analysis. Measures of accuracy and Q point value (Q*) were calculated using summary receiver operating characteristic (SROC) curve. The potential between-studies heterogeneity was explored by subgroup analysis. Results Nine studies were included in the present meta-analysis. Overall, the prevalence was 50.6%; the sensitivity was 0.87 (95% confidence interval (CI), 0.72–0.95); the specificity was 0.79 (95% CI, 0.56–0.92); the positive likelihood ratio (PLR) was 4.18 (95% CI, 1.78–9.86); the negative likelihood ratio (NLR) was 0.16 (95% CI, 0.07–0.36), and the diagnostic odds ratio (DOR) was 25.60 (95% CI, 7.28–89.93). The area under the SROC curve was 0.91 (95% CI, 0.88–0.93), with a Q* of 0.83. Subgroup analysis showed that the assay method and cutoff value influenced the diagnostic accuracy of sTREM-1. Conclusions BALF sTREM-1 is a useful biomarker of bacterial lung infections in ICU patients. Further studies are needed to confirm the optimized cutoff value.
Measurement-Based Modeling of Contact Forces and Textures for Haptic Rendering

Haptic texture represents the fine-grained attributes of an object's surface and is related to physical characteristics such as roughness and stiffness. We introduce an interactive and mobile scanning system for the acquisition and synthesis of haptic textures that consists of a visually tracked handheld touch probe. The most novel aspect of our work is an estimation method for the contact stiffness of an object based solely on the acceleration and forces measured during stroking of its surface with the handheld probe. We establish an experimental relationship between the estimated stiffness and the contact stiffness observed during compression. We also measure the height-displacement profile of an object's surface enabling us to generate haptic textures. We show an example of mapping the textures on to a coarse surface mesh obtained with an image-based technique, but the textures may also be combined with coarse surface meshes obtained by manual modeling.
Effect of Stage‐Specific Vital Rates on Population Growth Rates and Effective Population Sizes in an Endangered Iteroparous Plant

Abstract: Effective population size (N e ) determines the strength of genetic drift and can influence the level of genetic diversity a population can maintain. Assessing how changes in demographic rates associated with environmental variables and management actions affect N e thus can be crucial to the conservation of endangered species. Calculation of N e through demographic models makes it possible to use elasticity analyses to study this issue. The elasticity of N e to a given vital rate is the proportional change in N e associated with a proportional increase in that vital rate. In addition, demographic models can be used to study N e and population growth rate (λ) simultaneously. Simultaneous examination is important because some vital rates differ diametrically in their associations with λ and N e . For example, in some cases increasing these vital rates increases λ and decreases N e . We used elasticity analysis to study the effect of stage‐specific survival and flowering rates on N e, annual effective population size (Na), and λ in seven populations of the endangered plant Austrian dragonhead (Dracocephalum austriacum). In populations with λ≥ 1, the elasticities of Neand Na were similar to those of λ. Survival rates of adults were associated with greater elasticities than survival rates of juveniles, flowering rates, or fecundity. In populations with λ < 1, Neand Na exhibited greater elasticities to juvenile than to adult vital rates. These patterns are similar to those observed in other species with similar life histories. We did not observe contrasting effects of any vital rate on λ and Ne; thus, management actions that increase the λ of populations of Austrian dragonhead will not increase genetic drift. Our results show that elasticity analyses of Neand Na can complement elasticity analysis of λ. Moreover, such analyses do not require more data than standard matrix models of population dynamics.
DGK-α: A Checkpoint in Cancer-Mediated Immuno-Inhibition and Target for Immunotherapy

Immunotherapy is moving to the forefront of cancer treatments owing to impressive durable responses achieved with checkpoint blockade antibodies and adoptive T-cell therapy. Still, improvements are necessary since, overall, only a small percentage of patients benefit from current therapies. Here, I summarize evidence that DGK-α may represent an immunological checkpoint suppressing the activity of cytotoxic immunocytes in the tumor microenvironment. DGK-inhibitors can restore the antitumor function of tumor-suppressed adaptive and innate cytotoxic immunocytes. The activity of DGK-inhibitors lays downstream of current checkpoint blockade antibodies. Thus, synergistic effects are expected from combination strategies. Moreover, DGK-inhibitors may permit a double-strike attack on tumor cells as DGK-inhibition may not only re-instate immunological tumor attack but also may harm tumor cells directly by interfering with oncogenic survival pathways. Together, DGK-inhibitors have very promising characteristics and may be beneficially included into the armamentarium of cancer immunotherapeutics.
Complex Regulation of the DnaJ Homolog CbpA by the Global Regulators σS and Lrp, by the Specific Inhibitor CbpM, and by the Proteolytic Degradation of CbpM

ABSTRACT CbpA is a DnaJ homolog that functions as a DnaK cochaperone. Several cellular processes, including growth at low and high temperatures and septum formation during cell division, require either CbpA or DnaJ. CbpA is encoded in an operon with the gene for CbpM, which is a specific in vivo and in vitro inhibitor of CbpA. Here, we have cooverexpressed CbpA with CbpM in a ΔcbpAM ΔdnaJ strain and examined the resulting phenotypes. Under these conditions, sufficient free CbpA activity was present to support growth at low temperatures, but not at high temperatures. Defects in cell division and in λ replication were also partially complemented by CbpA when cooverexpressed with CbpM. Utilizing reporter fusions, we demonstrated that the cbpAM operon was maximally transcribed at the transition from exponential growth to stationary phase. Transcription was controlled by the σS and Lrp global regulators, and both leucine availability and growth temperature influenced transcription. CbpA and CbpM accumulated to similar levels in stationary phase, ∼2,300 monomers per cell. When not bound to CbpA, CbpM was unstable and was degraded by the Lon and ClpAP proteases. These data demonstrate that CbpA activity is controlled at multiple levels.
Automatic data environment construction for static device drivers analysis

Linux contains thousands of device drivers that are developed independently by many developers. Though each individual driver source code is relatively small---≈10k lines of code---the whole operating system contains a few million lines of code. Therefore Linux device drivers offer a useful application area for modular analysis.Our finding is that despite the precise modeling of most features of the standard systems programming language C, model checking software verification tools for C fail to provide means for modular analysis of device drivers. We inspected CBMC [2], SLAM-SDV [3], MAGIC [1], BLAST [4] and others and found that a rich additional environment model for every device driver is needed. This model must provide information on out-of-scope initialized pointers and complex data structures. We present strategies to automatically create feasible, bounded data environments for Linux device drivers instead of creating them manually. Our solution differs from general interface generation mechanisms (e.g. CUTE[5]), because is it specialised on bounded model checking of Linux device drivers written in C. Our contribution is a preprocessing step that extends the usability of CBMC for modular Linux device driver analysis.
Comparison of the Prevalence of Common Bacterial Pathogens in the Oropharynx and Nasopharynx of Gambian Infants

Background CRM- based pneumococcal conjugate vaccines generally have little impact on the overall prevalence of pneumococcal carriage because of serotype replacement. In contrast, protein vaccines could substantially reduce the overall prevalence of pneumococcal carriage with potential microbiological and clinical consequences. Therefore, trials of pneumococcal protein vaccines need to evaluate their impact on carriage of other potentially pathogenic bacteria in addition to the pneumococcus. Methods As a prelude to a trial of an investigational pneumococcal vaccine containing pneumococcal polysaccharide conjugates and pneumococcal proteins, the prevalence of carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella species and Staphylococcus aureus in the nasopharynx of 1030 Gambian infants (median age 35 weeks) was determined. An oropharyngeal swab was obtained at the same time from the first 371 infants enrolled. Standard microbiological techniques were used to evaluate the bacterial flora of the pharynx and to compare that found in the oropharynx and in the nasopharynx. Results The overall pneumococcal carriage rate was high. Isolation rates of S. pneumoniae and Moraxella species were significantly higher using nasopharyngeal rather than oropharyngeal swabs (76.1% [95% CI 73.4%,78.7%] vs. 21.3% [95% CI 17.2%,25.8%] and 48.9% [95% CI 45.8%, 52.0%] vs. 20.5% % [95% CI 16.5%,25.0%] respectively). In contrast, S. aureus and H. influenzae were isolated more frequently from oropharyngeal than from nasopharyngeal swabs (65.0% [95% CI 59.9%, 69.8%] vs. 33.6% [95% CI 30.7%, 36.5%] and 31.8% [95% CI 16.5%, 25.0%] vs. 22.4% [95% CI 19.9%, 25.1%] respectively). No group A β haemolytic streptococci were isolated. Conclusion Collection of an oropharyngeal swab in addition to a nasopharyngeal swab will provide little additional information on the impact of a novel pneumococcal vaccine on pneumococcal carriage but it might provide additional, valuable information on the impact of the vaccine on the overall microbiota of the pharynx.
Cattle demographic history modelled from autosomal sequence variation

The phylogeography of cattle genetic variants has been extensively described and has informed the history of domestication. However, there remains a dearth of demographic models inferred from such data. Here, we describe sequence diversity at 37 000 bp sampled from 17 genes in cattle from Africa, Europe and India. Clearly distinct population histories are suggested between Bos indicus and Bos taurus, with the former displaying higher diversity statistics. We compare the unfolded site frequency spectra in each to those simulated using a diffusion approximation method and build a best-fitting model of past demography. This implies an earlier, possibly glaciation-induced population bottleneck in B. taurus ancestry with a later, possibly domestication-associated demographic constriction in B. indicus. Strikingly, the modelled indicine history also requires a majority secondary admixture from the South Asian aurochs, indicating a complex, more diffuse domestication process. This perhaps involved multiple domestications and/or introgression from wild oxen to domestic herds; the latter is plausible from archaeological evidence of contemporaneous wild and domestic remains across different regions of South Asia.
Model Reduction for Nonlinear Control Systems using Kernel Subspace Methods

We introduce a data-driven order reduction method for nonlinear control systems, drawing on recent progress in machine learning and statistical dimensionality reduction. The method rests on the assumption that the nonlinear system behaves linearly when lifted into a high (or infinite) dimensional feature space where balanced truncation may be carried out implicitly. This leads to a nonlinear reduction map which can be combined with a representation of the system belonging to a reproducing kernel Hilbert space to give a closed, reduced order dynamical system which captures the essential input-output characteristics of the original model. Empirical simulations illustrating the approach are also provided.
Microfluidic EBG Sensor Based on Phase-Shift Method Realized Using 3D Printing Technology

In this article, we propose a novel microfluidic microstrip electromagnetic band gap (EBG) sensor realized using cost-effective 3D printing technology. Microstrip sensor allows monitoring of the fluid properties flowing in the microchannel embedded between the microstrip line and ground plane. The sensor’s operating principle is based on the phase-shift method, which allows the characterization at a single operating frequency of 6 GHz. The defected electromagnetic band gap (EBG) structure is realized as a pattern in the microstrip ground plane to improve sensor sensitivity. The designed microfluidic channel is fabricated using a fused deposition modelling (FDM) 3D printing process without additional supporting layers, while the conductive layers are realized using sticky aluminium tape. The measurement results show that the change of permittivity of the fluid in the microfluidic channel from 1 to 80 results in the phase-shift difference of almost 90°. The potential application is demonstrated through the implementation of a proposed sensor for the detection of toluene concentration in toluene–methanol mixture where various concentrations of toluene were analysed.
Towards Classifying Third-Party Web Services at Scale

Many people are concerned about privacy in the Web. This has resulted in the emergence of various tools and suggestions for blocking tracking services. However, in order to block or analyze tracking services, these services have to be identified first. In this work we develop and evaluate a set of features for identifying tracking services in HTTP traffic. Our approach enables us to verify the effectiveness of existing blocking approaches as well as to find more candidates for blacklisting.