Miracle-dz/UniFAR-FTUs huggingface dataset:
HDGF在手术切除非小细胞肺癌中的异常表达及其在预测预后中的意义

背景与目的 在前期研究中发现肝癌衍生生长因子（hepatoma-derived growth factor, HDGF）在A549、H226等非小细胞肺癌（non-small cell lung cancer, NSCLC）细胞中明显高表达，在促进NSCLC细胞侵袭、生长、迁移过程中起重要作用。 本研究旨在进一步检测HDGF在NSCLC组织标本中的表达情况，探讨其临床意义。 方法 应用SP法，检测158例手术切除NSCLC及12例正常对照肺组织中HDGF蛋白表达情况，进行生存分析、预后判定。 结果 与12例正常对照肺组织比较，HDGF蛋白在158例NSCLC中明显高表达（P < 0.001）。 158例NSCLC中，HDGF高表达组（78例，占49. 4%）的5年生存率为38. 2%，明显低于HDGF低表达组（80例，占50. 6%）的5年生存率63. 1%（P=0.009）。 直线相关分析表明HDGF表达水平与术后生存时间呈负相关（r=-0.183, P=0.022）。 多因素生存分析表明术后病理分期和HDGF表达水平是手术切除NSCLC预后判定的独立因素。 结论 HDGF在NSCLC中呈现高表达；HDGF高表达代表预后不良，HDGF可以作为手术切除NSCLC预后判定的新的分子标志物。
Locking Range of Frequency Dividers With Dual-Resonance Tank

Closed-form expressions are derived for predicting the locking ranges and the amplitudes of the locked oscillations of injection locking frequency dividers (ILFDs) with dual-resonance tank. The stability of the predicted locked-states is also assessed, showing that these are always stable in the locking ranges. These results are obtained by a proper transformation of the circuit equations that are reduced to a quasi-normal form by a suitable change of the circuit variables and then solved by applying the method of slowly varying amplitudes and phases. The derived formulas give results significantly more accurate than that resulting from the well-known Adler’s equation, improperly applied in practice to ILFDs with dual resonance tank. Numerical results, obtained by using BSIM3 transistor models, validate the presented results.
Sequence Modelling For Analysing Student Interaction with Educational Systems

The analysis of log data generated by online educational systems is an important task for improving the systems, and furthering our knowledge of how students learn. This paper uses previously unseen log data from Edulab, the largest provider of digital learning for mathematics in Denmark, to analyse the sessions of its users, where 1.08 million student sessions are extracted from a subset of their data. We propose to model students as a distribution of different underlying student behaviours, where the sequence of actions from each session belongs to an underlying student behaviour. We model student behaviour as Markov chains, such that a student is modelled as a distribution of Markov chains, which are estimated using a modified k-means clustering algorithm. The resulting Markov chains are readily interpretable, and in a qualitative analysis around 125,000 student sessions are identified as exhibiting unproductive student behaviour. Based on our results this student representation is promising, especially for educational systems offering many different learning usages, and offers an alternative to common approaches like modelling student behaviour as a single Markov chain often done in the literature.
Nonparametric Hypothesis Testing with Parametric Rates of Convergence

Nonparametric estimators are frequently criticized for their poor performance in small samples. In this paper, the author considers using kernel methods for the estimation of the expected derivatives of a regression function. The proposed estimators are shown to be asymptotically normal and n-consistent. As a consequence, their standard errors are comparable to parametric estimates. An empirical example demonstrates the facility of the approach. Copyright 1991 by Economics Department of the University of Pennsylvania and the Osaka University Institute of Social and Economic Research Association.
Fear conditioned potentiation of the acoustic blink reflex in patients with cerebellar lesions

OBJECTIVE To investigate whether the human cerebellum takes part in fear conditioned potentiation of the acoustic blink reflex. METHODS A group of 10 cerebellar patients (eight patients with lesions involving the medial cerebellum, two patients with circumscribed lesions of the cerebellar hemispheres) was compared with a group of 16 age and sex matched healthy control subjects. The fear conditioned potentiation paradigm consisted of three phases. During the first, habituation phase subjects received 20 successive acoustic blink stimuli. In the subsequent fear conditioning phase, subjects passed through 20 paired presentations of the unconditioned fear stimulus (US; an electric shock) and the conditioned stimulus (CS; a light). Thereafter, subjects underwent the potentiation phase, which consisted of a pseudorandom order of 12 trials of the acoustic blink stimulus alone, 12 acoustic blink stimuli paired with the conditioned stimulus, and six conditioned stimuli paired with the unconditioned stimulus. The EMG of the acoustic blink reflex was recorded at the orbicularis oculi muscles. The potentiation effect was determined as the difference in normalised peak amplitude of the blink reflex evoked by pairs of CS and acoustic blink stimuli and evoked by the acoustic stimulus alone. RESULTS In the habituation phase, short term habituation of the acoustic blink reflex was preserved in all cerebellar patients. However, in the potentiation phase, the potentiation effect of the blink reflex was significantly reduced in patients with medial cerebellar lesions compared with the controls (mean (SD) potentiation effect (%), patients: −6.4 (15.3), controls: 21.6 (35.6)), but was within normal limits in the two patients with lateral lesions. CONCLUSIONS The present findings suggest that the human medial cerebellum is involved in associative learning of non-specific aversive reactions—that is, the fear conditioned potentiation of the acoustic blink reflex.
Molecular Docking Studies of Mycobacterium tuberculosis RNA Polymerase β Subunit (rpoB) Receptor

— Tuberculosis (TB) is a bacterial infectious disease caused by the obligate human pathogen, Mycobacterium tuberculosis. Multidrug-resistant tuberculosis (MDR-TB) is a global reality that threatens tuberculosis control. Resistance to antibiotic Rifampicin, occurs in 95% of cases through nucleotide substitutions in an 81-bp core region of the rpoB i.e; beta subunit of DNA dependant RNA polymerase. In this paper, we studied the Rifampicin-rpoB receptor interactions In silico . First, homology modeling was performed to obtain the three dimensional structure of Mycobacterium rpoB. Sixty analogs of Rifampicin were prepared using Marvin sketch software. Both original Rifampicin and the analogs were docked with rpoB and energy values were obtained. Out of sixty analogs, 43 analogs had lesser energy values than conventional Rifampicin and hence are predicted to have greater binding affinity to rpoB. Thus, this study offers a route for the development of Rifampicin analogs against multi drug resistant Mycobacterium rpoB.
Examining complex unit roots in the MENA countries industrial production indices

An estimation of complex unit roots is presented based on the standardized periodogram of the Jordanian and Israeli Industrial Production indices over the period 1982–2003. Both indices are found to have six complex cyclical unit roots contents. In contrast, the propagation mechanism rather than impulse tends to drive the business cycles in those economies. Propagation consists of those forces which carry the influences of the shock forward over time and cause deviation from the steady state to be persistent. The periodogram-based cycle duration analysis reveals that both Kitchin and Juglar cycles exist in the Israeli economy. However, no investment cycles are found in the Jordanian economy.
Jointly spatial-spectral resolution enhancement of hyperspectral imagery

For hyperspectral image, low spatial and spectral resolution will cause inaccurate object detection and classification. In this paper, a novel jointly spatial-spectral resolution enhancement algorithm is proposed to promote the spatial resolution and spectral resolution simultaneously, high spatial resolution information from panchromatic image is used as constraint in spectral enhancement while the high spectral resolution details are benefited for spatial enhancement, which makes spatial SR and spectral SR promote each other. The experiments prove that our algorithm can provide joint spatial-spectral enhanced results, which can outperform the state-of-art methods both in spatial and spectral domains.
Nonlinear PI control for three-phase PWM AC-DC converter

This paper proposes a nonlinear PI control strategy for three-phase PWM AC-DC voltage source converter. The nonlinear controller, consisting of the special nonlinear function of the error and the traditional PI regulator, improves the DC voltage response as well as the robustness against the load uncertainty. In addition, the sinusoidal AC current and unity power factor is achieved. This controller is also easy to be realized. The simulation and experimental results are provided to verify the validity of the proposed control algorithm
BEING A CORPORATE CITIZEN IN INDIA: HISTORY AND SITUATION TODAY

The aim of this paper is to explore the current situation of corporate citizenship in India and its evolution over time, comparing it with industrialised countries. It attempts to compare and contrast two systems of Corporate Citizenship (CC), one in the U.S. and the other in India, each in a different phase of maturity. Observing the definition of CC in its westernised context, there is a literature gap regarding the behaviour of corporates, including local and multi-national corporations. This paper highlights the fact such entities in India are actually practising CSR and not CC.
Splice, Insertion‐Deletion and Nonsense Mutations that Perturb the Phenylalanine Hydroxylase Transcript Cause Phenylketonuria in India

Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by mutational inactivation of the phenylalanine hydroxylase (PAH) gene. Missense mutations are the most common PAH mutation type detected in PKU patients worldwide. We performed PAH mutation analysis in 27 suspected Indian PKU families (including 7 from our previous study) followed by structure and function analysis of specific missense and splice/insertion–deletion/nonsense mutations, respectively. Of the 27 families, disease‐causing mutations were detected in 25. A total of 20 different mutations were identified of which 7 “unique” mutations accounted for 13 of 25 mutation positive families. The unique mutations detected exclusively in Indian PKU patients included three recurrent mutations detected in three families each. The 20 mutations included only 5 missense mutations in addition to 5 splice, 4 each nonsense and insertion–deletion mutations, a silent variant in coding region and a 3′UTR mutation. One deletion and two nonsense mutations were characterized to confirm significant reduction in mutant transcript levels possibly through activation of nonsense mediated decay. All missense mutations affected conserved amino acid residues and sequence and structure analysis suggested significant perturbations in the enzyme activity of respective mutant proteins. This is probably the first report of identification of a significantly low proportion of missense PAH mutations from PKU families and together with the presence of a high proportion of splice, insertion–deletion, and nonsense mutations, points to a unique PAH mutation profile in Indian PKU patients. J. Cell. Biochem. 115: 566–574, 2014. © 2013 Wiley Periodicals, Inc.
The Status of Daily Physical Activity in Northern Ontario’s Elementary Public Schools

The importance of daily physical activity (DPA) for children and youth is highlighted in Canada’s Active Healthy Kids annual report on fitness. Since 2005, this report has revealed that elementary-aged students are spending most of their waking hours stationary, in front of screens (phones, televisions, computers). To counteract this trend, the Ministry of Education in Ontario introduced policy that ensured elementary schools deliver 20 minutes of DPA beyond Physical Education classes. However, 9 years later, students remain relatively inactive during school hours. This study examined the barriers believed by Northern Ontario elementary teachers and administrators to influence their abilities to include DPA into their daily timetables. Results showed that the depleting priority of DPA in elementary schools, the absence of student and teacher mentorship, and fewer leisure time minutes during the school day were key variables in the exclusion of school-based DPA. Interestingly, many of these challenges were overcome in schools governed by school-based practices and policies that supported DPA. In these particular schools, participants expressed that their internal resources were the best defense against detractive forces that marginalized school-based physical activity.
18F-FDG-PET/CT in Initiation and Progression of Inflammation and Infection

Objective: Detection/localization of infection and inflammation is important for the initiation of correct treatment as well as its maintenance. Nuclear medicine imaging methods play an important role in determining infection and inflammation. 18F-2’-deoxy-2-fluoro-d-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is highly sensitive in such cases when used with tomographic cross-sections. In this study, the development and progression of infection and inflammation were monitored on rats by using 18F-FDG via PET/CT. Methods: Sterile and infected abscesses were formed on rats using turpentine and S. aureus, respectively. For evaluation of the formation and progression of the abscess, 18F-FDG was injected into the rats and they were imaged by PET/CT at intervals of twenty-four hours for five days. Maximum standard uptake value (SUVmax) of 18F-FDG was calculated. Results: The highest activity involvement was seen on the first day of abscess formation. On the first day, SUVmax of the S. aureus abscess was 3.9±0.9 while in the sterile abscess SUVmax in the first day was 2.2±0.8. 18F-FDG uptake decreased day by day and it reached the background level on the fourth and fifth days. There were statistically significant differences between S. aureus and sterile abscess, and between sterile abscess and background activity in terms of SUVmax values during the first three days (p<0.05). On the fourth and fifth days, there was no statistically significant difference between S. aureus and sterile abscess, and between sterile abscess and background activity (p>0.05). Conclusion: The results demonstrated that the SUVmax value for 18F-FDG can be useful in the early differentiation of sterile and infected abscess. In addition, 18F-FDG-PET imaging has the advantage of local availability of equipment and labeled agents leading rapid diagnosis of differentiation of infection and inflammation.
The Brazilian version of the 20-item rapid estimate of adult literacy in medicine and dentistry

Background The misunderstanding of specific vocabulary may hamper the patient-health provider communication. The 20-item Rapid Estimate Adult Literacy in Medicine and Dentistry (REALMD-20) was constructed to screen patients by their ability in reading medical/dental terminologies in a simple and rapid way. This study aimed to perform the cross-cultural adaptation and validation of this instrument for its application in Brazilian dental patients. Methods The cross-cultural adaptation was performed through conceptual equivalence, verbatim translation, semantic, item and operational equivalence, and back-translation. After that, 200 participants responded the adapted version of the REALMD-20, the Brazilian version of the Rapid Estimate of Adult Literacy in Dentistry (BREALD-30), ten questions of the Brazilian National Functional Literacy Index (BNFLI), and a questionnaire with socio-demographic and oral health-related questions. Statistical analysis was conducted to assess the reliability and validity of the REALMD-20 (P < 0.05). Results The sample was composed predominantly by women (55.5%) and white/brown (76%) individuals, with an average age of 39.02 years old (±15.28). The average REALMD-20 score was 17.48 (±2.59, range 8–20). It displayed a good internal consistency (Cronbach’s alpha = 0.789) and test-retest reliability (ICC = 0.73; 95% CI [0.66 − 0.79]). In the exploratory factor analysis, six factors were extracted according to Kaiser’s criterion. The factor I (eigenvalue = 4.53) comprised four terms— “Jaundice”, “Amalgam”, “Periodontitis” and “Abscess”—accounted for 25.18% of total variance, while the factor II (eigenvalue = 1.88) comprised other four terms—“Gingivitis”, “Instruction”, “Osteoporosis” and “Constipation”—accounted for 10.46% of total variance. The first four factors accounted for 52.1% of total variance. The REALMD-20 was positively correlated with the BREALD-30 (Rs = 0.73, P < 0.001) and BNFLI (Rs = 0.60, P < 0.001). The scores were significantly higher among health professionals, more educated people, and individuals who reported good/excellent oral health conditions, and who sought preventive dental services. Distinctly, REALMD-20 scores were similar between both participants who visited a dentist <1 year ago and ≥1 year. Also, REALMD-20 was a significant predictor of self-reported oral health status in a multivariate logistic regression model, considering socio-demographic and oral health-related confounding variables. Conclusion The Brazilian version of the REALMD-20 demonstrated adequate psychometric properties for screening dental patients in relation to their recognition of health specific terms. This instrument can contribute to identify individuals with important dental/medical vocabulary limitations in order to improve the health education and outcomes in a person-centered care model.
Core self-evaluations and salary attainment: the moderating role of the developmental network

Core self-evaluation (CSE) has been shown to be robust as a predictor of employees' salary attainment. Although the developmental network is suggested to have a positive impact on salary, do all high-CSE individuals benefit from their developmental networks similarly? We incorporate both personality research and developmental network research to explore this question in two studies. In Study 1, we investigated whether developmental network size moderates the positive CSE–salary relationship. In Study 2, we explored whether the organizational status and the strength of ties of one's developers moderate the positive CSE–salary relationship. Results indicated that high-CSE individuals with developmental networks characterized by fewer developers and by strong ties reported higher salaries than others. Overall, our findings demonstrate that the positive CSE–salary link may vary depending on the structural characteristics of the developmental network.
Local health policy development processes : health promotion and network perspectives on local health policy-making in the Netherlands

This thesis reports on a study into developnlent processes of local health policy in four municipaliQes in Central Limburg, the Netherlands. Health policy is used here lur the sense of an integrated pol~cy acAhowled@ng the multi-dimensionality and multiple determinants of health. The aim of the study was to identify the factors and actors influencing these processes. It also examined the relation between the community-based Hartslag I(A/Pidden) Limburg cardiovascular prevention project and local health policy-making. The study focused on health promo'clon asld network perspectives.
Dynamic sensitivity analysis in Levy process driven option models

Option prices in the Black-Scholes model can usually be expressed as solutions of partial differential equations (PDE). In general exponential Levy models an additional integral term has to be added and the prices can be expressed as solutions of partial integro-differential equations (PIDE). The sensitivity of a price function to changes in its arguments is given by its derivatives, in finance known as greeks. The greeks can be obtained as a solution to a PDE or PIDE which is obtained by differentiating the equation and side conditions of the price function. We call the method of simultaneously solving the equations for the price function and the greeks the dynamic partial (-integro) differential approach. So far this approach has been analysed for a few contracts in the Black-Scholes model and in a Markov Chain model. In this thesis, we extend the use of the dynamic approach in the Black-Scholes model and apply it to a financial market where the underlying stock prices are driven by Levy processes. We derive and solve systems of equations that determine the price and the greeks both for vanilla and for exotic options. In particular we are interested in options whose prices depend only on time and one state variable. Furthermore, we calculate sensitivities of option prices with respect to changes in the stochastic model of the underlying price process. Such sensitivities can again be expressed as solutions to PIDE. The occurring systems of PIDE are solved numerically via a finite difference approach and the results are compared with simulation and numerical integration methods to compute prices and sensitivities. We show that the dynamic approach in many cases outperforms its competitors. Finally, we investigate the smoothness of the price functions and give conditions for the existence of solutions of the PIDE.
Multiagent System Simulations of Sealed-Bid Auctions with Two-Dimensional Value Signals

This study uses a multiagent system to investigate how sealed-bid auction results vary across twodimensional value signals from pure private to pure common value. I find that several auction outcomes are significantly nonlinear across the two-dimensional value signals. As the common value percent increases, profit, revenue, and efficiency all decrease monotonically, but they decrease in different ways. Finally, I find that forcing revelation by the auction winner of the true common value may have beneficial revenue effects when the common-value percent is high and there is a high degree of uncertainty about the common value.
Schalkwijk and Kailath feedback coding with sequential decision-making

Low latency and high energy-efficiency will be key features of many future communication systems. It is known that feedback coding like the well known Schalkwijk and Kailath (SK) coding scheme outperforms feedforward coding in terms of the decoding error probability. In the present paper, the additional gain by combining the capacity-achieving feedback coding scheme by SK with sequential decision-making based on the multiple hypotheses test by Baum et al. is studied. An analytical approximation for the minimum Eb /No to transmit k bits is derived under a given constraint on the decoding error probability. The theoretical results are compared to Monte Carlo simulations. With this approach a significant reduction in blocklength or latency and a further reduction of the required Eb /No w.r. t. the original SK scheme can be achieved. For evaluation the results are compared to the analytical results of Polyanskiy et al. for the additive white Gaussian noise channel with and without feedback.