Miracle-dz/UniFAR-FTUs huggingface dataset:
White matter hyperintensity progression and late-life depression outcomes.

CONTEXT White matter hyperintensities (WMHs) are bright foci seen in the parenchyma of the brain on T2-weighted cranial magnetic resonance imaging (MRI) scans and are associated with geriatric depression. Because they are associated with age, they should increase in number and size over time. To our knowledge, this is the first longitudinal, volumetric MRI study of WMHs in depression. OBJECTIVE To determine if WMH progression over 2 years influences depression outcomes. DESIGN Over 2 years, depressed subjects received antidepressant treatment according to a naturalistic somatic treatment algorithm designed to offer the best possible treatment to the individual. After the treatment period, depressed subjects were dichotomized based on whether they had reached and sustained remission during this period. PARTICIPANTS One hundred thirty-three subjects aged 60 years or older meeting DSM-IV criteria for major depressive disorder. MEASURES Cranial MRI was obtained at baseline and approximately 2 years later. White matter hyperintensity volume was measured in each hemisphere using a semiautomated segmentation process. OUTCOMES Subjects were dichotomized based on achieving or not achieving remission of depressive symptoms, defined as a Montgomery-Asberg Depression Rating Scale score of 8 or less. RESULTS The depressed subgroup that achieved and sustained remission had significantly less increases in WMH volume (11.5%) than did the group that did not achieve or sustain remission (31.6%) (P =.01). In a regression model, greater change in WMH volume was significantly associated with failure to sustain remission (P =.004) even when controlling for baseline depression severity, medical illness severity, age, sex, and race. Education was associated with achieving and sustaining remission (P =.02). CONCLUSIONS Greater progression of WMH volume is associated with poor outcomes in geriatric depression. Future work is needed to develop means of slowing the rate of WMH progression and to determine whether this will lead to improved depression outcomes in elderly persons.
School Sector Differences in Student Achievement in Australian Primary and Secondary Schools: A Longitudinal Analysis

This article examines school sector differences in student performance Years 3, 5, and 7 in numeracy, reading, writing, spelling and grammar using data from the Longitudinal Study of Australian Children and the national testing program (NAPLAN). At each of the 3 Year levels, there are sizable school sector differences with students from independent schools exhibiting the substantially higher mean scores than Catholic and government school students. However, school sector differences in Years 3 and 5 largely disappear when taking into account students’ socioeconomic position and especially prior ability. In Year 7, there is evidence of value added effects for attending an independent school in numeracy, reading and writing but the effect sizes are quite small (around 0.10). Fixed effects analyses confirm small significant value-added effects for attending independent schools for numeracy and reading.1
Compartmentation of the Golgi complex: brefeldin-A distinguishes trans- Golgi cisternae from the trans-Golgi network

The Golgi complex is composed of at least four distinct compartments, termed the cis-, medial, and trans-Golgi cisternae and the trans-Golgi network (TGN). It has recently been reported that the organization of the Golgi complex is disrupted in cells treated with the fungal metabolite, brefeldin-A. Under these conditions, it was shown that resident enzymes of the cis-, medial, and trans-Golgi return to the ER. We report here that 300-kD mannose 6-phosphate receptors, when pulse- labeled within the ER of brefeldin-A-treated cells, acquired numerous N- linked galactose residues with a half time of approximately 2 h, as measured by their ability to bind to RCA-I lectin affinity columns. In contrast, Limax flavus lectin chromatography revealed that less than 10% of these receptors acquired sialic acid after 8 h in brefeldin-A. Two lines of evidence suggested that proteins within and beyond the TGN did not return to the ER in the presence of brefeldin-A. First, the majority of 300-kD mannose 6-phosphate receptors present in the TGN and endosomes did not return to the ER after up to 6 h in brefeldin-A, as determined by their failure to contact galactosyltransferase that had relocated there. Moreover, although mannose 6-phosphate receptors did not acquire sialic acid when present in the ER of brefeldin-A-treated cells, they were readily sialylated when labeled at the cell surface and transported to the TGN. These experiments indicate that galactosyltransferase, a trans-Golgi enzyme, returns to the endoplasmic reticulum in the presence of brefeldin-A, while the bulk of sialyltransferase, a resident of the TGN, does not. Our findings support the proposal that the TGN is a distinct, fourth compartment of the Golgi apparatus that is insensitive to brefeldin-A.
The Selection of Serum-independent PC12 Cells for a More-reliable Manganese Cytotoxicity Test

A major issue concerning the protocols of heavy metal cytotoxicity tests with PC12 cells was the hypothesis that serum in the culture medium might sequester the metal, thus altering the results obtained. However, serum withdrawal impairs the viability of PC12 cells themselves, thus impeding cytotoxicity testing in the absence of serum. In this study, we repeatedly selected undifferentiated, totally non-adherent PC12 cells in Petri dishes. Surprisingly, we discovered that these cells could survive and proliferate in serum-free medium. Moreover, features such as NGF-responsiveness, resazurin reduction potential, doubling rate, protein content, and basal caspase-3 enzyme activity, were equivalent to those exhibited by standard PC12 cultures. Further experiments aimed at fully characterising these serum-independent PC12 cells are in progress. These cells enabled cytotoxicity experiments to be conducted with manganese, both in serum-supplemented and in serum-deprived medium. The results demonstrated that serum removal decreased the LC50 of manganese from 250μM to 32μM, without affecting the internalisation of the metal. The data exclude an early competitive effect of serum on metal internalisation; rather, they suggest a late protective mechanism mediated by serum against the cytotoxic effect of the already-internalised metal.
An Efficient Code Compression Technique using Application-Aware Bitmask and Dictionary Selection Methods

Memory plays a crucial role in designing embedded systems. A larger memory can accommodate more and large applications but increases cost, area, as well as energy requirements. Code compression techniques address this problem by reducing the size of the applications. While early work on bitmask-based compression has proposed several promising ideas, many challenges remain in applying them to embedded system design. This paper makes two important contributions to address these challenges by developing application-specific bitmask selection and bitmask-aw are dictionary selection techniques. The authors applied these techniques for code compression of TI and MediaBench applications to demonstrate the usefulness of the approach
Hayabusa: Simple and Fast Full-Text Search Engine for Massive System Log Data

In this study, we introduce a simple and high-speed search engine for large-scale system logs, called Hayabusa. Hayabusa uses SQLite, standard lightweight database software with GNU Parallel and general Linux commands, such that it can run efficiently without complex components. Network administrators can use Hayabusa to accumulate and store log information at high speeds and to search the logs quickly. In our experiments, Hayabusa required only 8 seconds to convert 1.2 M log messages into a database file. Moreover, Hayabusa required only 5 seconds to search a keyword from 1.7 billion records. Hayabusa achieved high-performance search speed in a stand-alone environment without a complex distributed environment. Compared with the distributed environment, Spark, the proposed stand-alone Hayabusa was approximately 27 times faster.
CGALmesh

CGALmesh is the mesh generation software package of the Computational Geometry Algorithm Library (CGAL). It generates isotropic simplicial meshes—surface triangular meshes or volume tetrahedral meshes—from input surfaces, 3D domains, and 3D multidomains, with or without sharp features. The underlying meshing algorithm relies on restricted Delaunay triangulations to approximate domains and surfaces and on Delaunay refinement to ensure both approximation accuracy and mesh quality. CGALmesh provides guarantees on approximation quality and on the size and shape of the mesh elements. It provides four optional mesh optimization algorithms to further improve the mesh quality. A distinctive property of CGALmesh is its high flexibility with respect to the input domain representation. Such a flexibility is achieved through a careful software design, gathering into a single abstract concept, denoted by the oracle, all required interface features between the meshing engine and the input domain. We already provide oracles for domains defined by polyhedral and implicit surfaces.
A Systematic Literature Review of Crowdsourcing-Based Research in Information Security

Crowdsourcing is a well-established concept in several application areas of computer science and information systems. While crowdsourcing is favored in areas such as information sharing, quality management or data acquisition, only little attention has been drawn to crowdsourcing capabilities for information security in the past. Since a few years an increase of crowdsourcing-based research in information security can be identified. To which extend remains unclear since a comprehensive overview of applied crowdsourcing techniques and related challenges is missing. In this paper we try to shed some light on this by conducting a systematic literature review based on the snowballing methodology. It delivered 23 relevant papers which we analyzed with respect to the following perspectives: (a) Bibliographic information, (b) applied research methodology, (c) addressed information security application context, (d) applied crowdsourcing approach, and (e) challenges for crowdsourcing-based research in information security. Finally, based on the described investigations, we give a comprehensive overview, and identify several challenges of crowdsourcing based research in information security.
Semi-structured document image matching and recognition

This article presents a method to recognize and to localize semi-structured documents such as ID cards, tickets, invoices, etc. Standard object recognition methods based on interest points work well on natural images but fail on document images because of repetitive patterns like text. In this article, we propose an adaptation of object recognition for image documents. The advantages of our method is that it does not use character recognition or segmentation and it is robust to rotation, scale, illumination, blur, noise and local distortions. Furthermore, tests show that an average precision of 97.2% and recall of 94.6% is obtained for matching 7 different kinds of documents in a database of 2155 documents.
A Psychological Adaptive Model For Video Analysis

Extracting key-frames is the first step for efficient content-based indexing, browsing and retrieval of the video data in commercial movies. Most of the existing research deals with "how to extract representative frames? " However the unaddressed question is "how many key-frames are required to represent a video shot properly? " Generally, the user defines this number a priori or some heuristic methods are used. In this paper, we propose a psychological model, which computes this number adaptively and online, from variation of visual features in a video-shot. We incorporate it with an iterative key-frame selection method to automatically select the key-frames. We compare the results of this method with two other well-known approaches, based on a novel effectiveness measure that scores each approach based on its representational power. Movie-clips of varying complexity are used to underscore the success of the proposed model in real-time
Wikipedia Knowledge Graph with DeepDive

Despite the tremendous amount of information on Wikipedia, only a very small amount is structured. Most of the information is embedded in unstructured text and extracting it is a non trivial challenge. In this paper, we propose a full pipeline built on top of DeepDive to successfully extract meaningful relations from the Wikipedia text corpus. We evaluated the system by extracting company-founders and family relations from the text. As a result, we extracted more than 140,000 distinct relations with an average precision above 90%.
Improved ion transmission from atmospheric pressure to high vacuum using a multicapillary inlet and electrodynamic ion funnel interface

A heated multicapillary inlet and ion funnel interface was developed to couple an electrospray ionization (ESI) source to a high-vacuum stage for obtaining improved sensitivity in mass spectrometric applications. The inlet was constructed from an array of seven thin-wall stainless steel tubes soldered into a central hole of a cylindrical heating block. An electrodynamic ion funnel was used in the interface region to more effectively capture, focus, and transmit ions from the multicapillary inlet. The interface of seven capillary inlets with the ion funnel showed more than 7 times higher transmission efficiency compared to that of a single capillary inlet with the ion funnel and a 23-fold greater transmission efficiency than could be obtained using the standard orifice-skimmer interface of a triple-quadrupole MS. The multiple-capillary inlet and ion funnel interface showed an overall 10% ion transmission efficiency and approximately 3-4% overall detection efficiency of ions from solution based (i.e., prior to electrospray). The improved performance was achieved under conditions where ESI operation is robust and results in a significant increase in dynamic range.
COLOR AND SHAPE BASED REASSEMBLY OF FRAGMENTED IMAGES

-The manual execution of reassembling a fragmented image is very difficult. To overcome this difficulty a new technique was introduced in the existing system called “The novel integrated color based image fragments reassembly technique”. This technique is divided into four steps, which is based on color. Initially, the spatial adjacent image fragment is discovered. The second operation is to discovery of matching contour segments of adjacent image fragments. The next step is to find the appropriate geometrical transformation for an image fragments contour alignment. Finally the overall image assembly is done via novel based algorithms. In proposing system, the same reassembly technique is applied but additionally the shape alignment algorithm is used to utilize the shape of the fragment contours in order to perform matching. This will produce very satisfactory reassembly results and also it can lead to more efficient, significant reduction in human effort.
Children and Their Monsters

This article offers some reflections on how to work with children who bring their monsters to therapy using play therapy, drawing, and storytelling (Poda, 2011). The author draws on transactional analysis theories of trauma (Clarkson, 1988; Stuthridge, 2006) and script to conceptualize what might be happening with these children at the structural ego state level. Stressing the importance of the therapeutic relationship, an approach is outlined for restructuring ego states using transference, contracting, Berne’s therapeutic operations, and self-reparenting. Case examples illustrate how to conceptualize the child’s relationship to his or her monsters, how the therapist might meet them, and how to domesticate them.
3D multi-modal registration for assessing molecular activity changes in time-dependent geometries

An important issue for in-vivo fluorescence molecular imaging and tomography has been the robust registration of animals imaged at different time points in order to improve the accuracy of monitoring fluorophore distribution. This paper presents a novel automatic method for aligning 3D temporal data of small animals based on the robust detection of surface anatomical features. Since it is based on 3D surface landmarks the method can be used for mono-modal or multi-modal X-ray CT and/or Optical tomography data in order to account for differences in the positioning and compression of small animals. It can be further extended to other imaging modalities, as well.
Persistence of vertically transmitted parasite strains which protect against more virulent horizontally transmitted strains

The question whether a vertically and a horizontally transmitted parasite strain can coexist under complete cross protection is investigated in a host-parasite model with susceptibles and infectives only. It is shown that coexistence is possible even if the vertically transmitted strain would go extinct on its own provided that it is considerably less virulent than the horizontally transmitted strain. While the vertical transmitted strain is without benefit to the host as such, it protects the host against the more harmful horizontally transmitted strain. The coexistence is shown in the form of uniform strong persistence of the host and both parasite strains.
Influence of Plasma Glucose and Insulin Concentration on Plasma Glucose Clearance in Man

We examined the influence of plasma glucose concentration on whole-body glucose uptake and glucose clearance at two physiologic levels of hyperinsulinemia. Twelve healthy, young volunteers were divided into two groups (A and B); each subject participated in three studies. In group A, plasma insulin was raised and maintained by ∼100 μU/ml for 3 h, while plasma glucose concentration was clamped at hypoglycemic (60 ± 1 mg/dl), euglycemic (89 ± 1 mg/dl), or hyperglycemic (165 ± 3 mg/dl) levels. In group B, plasma insulin was raised by ∼50 μU/ml, while plasma glucose was clamped at 62 ± 1,86 ±2, or 143 ± 3 mg/dl for 3 h. At the higher insulin level (group A), glucose uptake rose from 5.2 ± 0.5 to 7.3 ± 0.6 to 12.2 ±1.0 mg/min· kg as plasma glucose was varied from low to high levels; glucose clearance fell slightly from 8.8 ± 1.0 to 7.8 ± 0.7 to 7.3 ± 0.6 ml/min·kg during the hypo-, eu-, and hyperglycemic clamps (P = NS). At the lower insulin level (group B), glucose uptake rose from 6.0 ± 1.2 to 8.1 ±1.7 mg/min·kg (P < 0.05) with increasing glucose levels, whereas glucose clearance fell significantly (P < 0.01) from 9.7 ± 1.8 to 5.6 ±1.1 ml/min·kg. When the data from both groups were analyzed together, insulin had a stimulatory effect on both glucose uptake and clearance. Elevation of the plasma glucose level had a similar stimulatory effect on glucose uptake (P < 0.001) but inhibited glucose clearance (P < 0.01). This inhibition, however, was modest (14% for the change from hypo- to euglycemia, and 16% for the change from eu- to hyperglycemia). We conclude that physiologic hyperglycemia exerts a modest inhibitory effect on glucose clearance, which is largely overcome at higher, yet still physiologic, plasma insulin levels (∼100 μU/ml).
Coordinating control of a two degrees of freedom universal joint structure driven by three servos

A structure of 3 servos driving a 2 d.o. f, universal joint through wire is introduced. A lower level coordinate transformation set is developed and includes positional, velocity and force transformations. Inverse transformations are included. Special attention is given to the inverse force transformation which is obtained using linear optimization. As an example a joint control system including servos under force control is outlined.
Is St George Enough? Considering the importance of displaying local identity while supporting the England national soccer team

Abstract Anthony King (2006) suggests that soccer provides an increasingly important arena to express an emergent English (over British) national identity. This paper uses data from pub‐based participant observation and an online survey conducted during the 2006 World Cup Finals to explore the complexities of contemporary English identities among ‘everyday’ soccer fans. We discuss the relevance of local identities by focusing on contemporary displays of support for the England team, particularly by supporters of clubs situated below the English Premier League that have been neglected in previous studies. We make reference to the ways in which local identities have often become interchangeable with the English nation, before suggesting that the nation can empower local identities when on an international stage. As such we regard support for the English national team as a site for expressing both national and local layers of identity that are informed in different ways by processes of globalisation.
Affect Regulation and the Origin of the Self: The Neurobiology of Emotional Development

Contents: J.S. Grotstein, Foreword. Preface. Part I:Background and Overview. Introduction. General Principles of Growth of the Developing Brain. Recent Advances in the Multidisciplinary Study of Emotional Development. Structure-Function Relationships of the Orbitofrontal Cortex. Overview. Part II:Early Infancy. Visual Experiences and Socioemotional Development. The Practicing Period. The Psychobiology of Affective Reunions. Early Imprinting. Imprinting Neuroendocrinology. Socioaffective Influences on Orbitofrontal Morphological Development. The Emotionally Expressive Face. The Neurochemical Circuitry of Imprinted Interactive Representations. The Regulatory Function of Early Internal Working Models. Part III:Late Infancy. The Onset of Socialization Procedures and the Emergence of Shame. Late Orbitofrontal Development. Orbitofrontal Versus Dorsolateral Prefrontal Ontogeny. The Dyadic Origin of Internal Shame Regulation. Socialization and Experience-Dependent Parcellation. The Origins of Infantile Sexuality and Psychological Gender. The Onset of Dual Component Orbitofrontal Mature Structure and Adaptive Function. Part IV:Applications to Affect Regulatory Phenomena. A Psychoneurobiological Model of the Dual Circuit Processing of Socioemotional Information. Cross-Modal Transfer and Abstract Representations. The Development of Increasingly Complex Interactive Representations. Orbitofrontal Influences on the Autonomic Nervous System. The Regulation of Infantile Rage Reactions. Affect Regulation and Early Moral Development. The Emergence of Self-Regulation. Part V:Clinical Issues. The Neurobiology of Insecure Attachments. The Clinical Psychiatry of Affect Dysregulation. The Developmental Psychopathology of Personality Disorders. Vulnerability to Psychosomatic Disease. Psychotherapy of Developmental Disorders. Part VI:Integrations. Right Hemispheric Language and Self-Regulation. The Dialogical Self and the Emergence of Consciousness. Further Directions of Multidisciplinary Study. A Proposed Rapprochement Between Psychoanalysis and Neurobiology.