Miracle-dz/UniFAR-FTUs huggingface dataset:
Element concentration changes in mitotically active and postmitotic enterocytes. An x-ray microanalysis study

Unfixed freeze-dried and uncoated tissue sections of the mouse duodenum were suspended across a hole in a carbon planchet and analyzed in a scanning electron microscope fitted with energy-dispersive x-ray analytical equipment. Computer analysis of the x-ray spectra allowed elemental microanalysis of the nucleus, cytoplasm, and late anaphase- early telophase chromatin regions in the cryptal and villus enterocytes. Elemental concentrations (mmol/kg dry wt) were measured for Na, Mg, P, S, Cl, K, and Ca. None of the elements were compartmentalized preferentially in either the nucleus or the cytoplasm of interphase enterocytes of crypts or in postmitotic enterocytes of villi. In contrast, Ca, S, and Cl are detectable in significantly higher concentrations in mitotic chromatin of dividing enterocytes of the crypt as compared to surrounding mitotic cytoplasm, but Na, Mg, and P are in lower concentrations in the mitotic chromatin as compared to mitotic cytoplasm. Interphase enterocytes of crypts have higher concentrations of Mg, P, and K, and lower concentrations of Na than do postmitotic enterocytes of villi.
Individual and Environmental Factors Influencing the Use of Transfer Strategies After Diversity Training

Change in work behavior is often the primary goal of diversity training, but few studies have examined transfer of diversity training. In this longitudinal field study, the authors measured cognitive, affective, and behavioral learning outcomes after a diversity training program as well as the subsequent use of transfer strategies on the job. They examined the influence of learning outcomes, trainee characteristics, and environmental characteristics on the use of transfer strategies. Trainee race/ethnicity and the work unit transfer climate are the best predictors of trainees' transfer strategy use. Among the learning outcomes, skill learning is the only significant predictor of transfer strategy use.
Long Time Stability of a Classical Efficient Scheme for Two-dimensional Navier-Stokes Equations

This paper considers the long-time stability property of a popular semi-implicit scheme for the two-dimensional incompressible Navier-Stokes equations in a periodic box that treats the viscous term implicitly and the nonlinear advection term explicitly. We consider both the semidiscrete (discrete in time but continuous in space) and fully discrete schemes with either Fourier Galerkin spectral or Fourier pseudospectral (collocation) methods. We prove that in all cases, the scheme is long time stable provided that the timestep is sufficiently small. The long time stability in the $L^2$ and $H^1$ norms further leads to the convergence of the global attractors and invariant measures of the scheme to those of the Navier-Stokes equations at vanishing timestep.
Organ dysfunction in patients with severe sepsis.

BACKGROUND Severe sepsis is defined as sepsis plus organ dysfunction. There is a need to quantify this dysfunction, and several scoring systems have been developed. METHOD Review of the pertinent English-language literature. RESULTS Early scoring of organ failure simply counted the number of failing organs, but the degree of dysfunction is an important variable. The first system to grade dysfunction was the multiple organ dysfunction score (MODS). The drawback of MODS is the variable used to quantify cardiovascular failure. To alleviate this limitation, the Brussels score was developed. However, it, too, was suboptimal and was replaced by the sequential or sepsis-related organ failure assessment (SOFA) score. There is a clear correlation between the total SOFA score and the mortality rate, and in certain studies, the total SOFA score was at least as good as traditional methods of predicting death. A key advantage of these simple scores is that they can be repeated to follow the course of organ dysfunction. The evolution of the SOFA score has been used to demonstrate the effects of various therapeutic interventions. CONCLUSION Quantifying organ dysfunction in patients with sepsis can assist in assessing prognosis and determining treatment effectiveness. The simplicity, reliability, and reproducibility of current scores facilitate their widespread use.
Relationship between playfulness and motor creativity in preschool children

Previous research has noted a corresponding relationship between young children's play and divergent thinking ability. This study examined how far fluency and flexibility in movement patterns' production, as indicatory elements of divergent thinking and critical thinking, are related to a variety of psychological elements (physical spontaneity, social spontaneity, cognitive spontaneity, manifest joy, sense of humor) that compositely contribute to playfulness, an internal personality characteristic. A total of two hundred and fifty preschool‐aged children participated in this study. Their teachers completed the Greek version of Children's Playfulness Scale. The Divergent movement ability test was used to rate children's motor creativity. The data indicated a significant correlation between total playfulness and (a) motor fluency and (b) motor flexibility. This means that playfulness and motor creativity are interconnected because movement during preschool age is the primary way of action, expression, learning and development.
Central serotonin system in dystonia musculorum mutant mice: Biochemical, autoradiographic and immunocytochemical data

The autosomal recessive mutation dystonia musculorum (dtJ/dtJ) causes degenerative alterations of peripheral and central sensory pathways that lead to ataxia. To investigate possible changes in the central serotonin system of these mice, HPLC measurements of 5‐hydroxytryptophan, 5‐hydroxy‐tryptamine (serotonin; 5‐HT), and 5‐HT metabolites were obtained from 22 brain regions and the spinal cord of wild type and dtJ/dtJ mutant mice. Also, 5‐HT transporters were quantified by [3H]citalopram autoradiography in 72 brain regions, subregions, and nuclei, and the 5‐HT innervation visualized by immunocytochemistry throughout the brain and spinal cord. In all brain regions measured for indoleamine content, there were no significant differences between the two genotypes. In the spinal cord, an increased tissue concentration of 5‐HT (+34%), 5‐hydroxyindole‐3‐acetic acid (+33%), 5‐hydroxytryptophol (+21%), and 5‐hydroxytryptophan (+45%) in dtJ/dtJ actually corresponded to the same total amount of each of these indoleamines in the entire spinal cord, when taking into account its reduced size in the mutants. Quantification of the binding to 5‐HT transporters showed increases in the medial geniculate nucleus (+14%), medial (+24%) and lateral (+18%) hypothalamus, interpeduncular (+13%), vestibular (+22%), and deep cerebellar nuclei (+37%) of dtJ/dt mice, and decreases in the ventral tegmental area (−13%), median and linear raphe nuclei (−20%), as well as in the solitary complex (−35%). There were no apparent differences in the distribution of 5‐HT‐immunostained fibers in these and other regions of brain and in the spinal cord of dtJ/dtJ compared to wild type mice. The bulk of these results indicates a relative sparing of the central 5‐HT system in the dtJ/dtJ mice, even though alterations in 5‐HT transporters could justify attempts at improving the sensorimotor dysfunction by administration of serotoninergic agents in these mice. Synapse 37:179–193, 2000. © 2000 Wiley‐Liss, Inc.
The Effect of Simple Melodic Lines on Aesthetic Experience: Brain Response to Structural Manipulations

This fMRI study investigates the effect of melody on aesthetic experience in listeners naive to formal musical knowledge. Using simple melodic lines, whose syntactic structure was manipulated, we created systematic acoustic dissonance. Two stimulus categories were created: canonical (syntactically “correct,” in the Western culture) and modified (made of an altered version of the canonical melodies). The stimuli were presented under two tasks: listening and aesthetic judgment. Data were analyzed as a function of stimulus structure (canonical and modified) and stimulus aesthetics, as appraised by each participant during scanning. The critical contrast modified versus canonical stimuli produced enhanced activation of deep temporal regions, including the parahippocampus, suggesting that melody manipulation induced feelings of unpleasantness in the listeners. This was supported by our behavioral data indicating decreased aesthetic preference for the modified melodies. Medial temporal activation could also have been evoked by stimulus structural novelty determining increased memory load for the modified stimuli. The analysis of melodies judged as beautiful revealed that aesthetic judgment of simple melodies relied on a fine-structural analysis of the stimuli subserved by a left frontal activation and, possibly, on meaning attribution at the charge of right superior temporal sulcus for increasingly pleasurable stimuli.
Unions in a Globalized Environment: Changing Borders, Organizational Boundaries and Social Roles

1. The Labor Movement in a New Globalized Environment: An Introduction, Bruce Nissen Part I: Cross-Border Organizing and Solidarity 2. Free Trade and Worker Solidarity in the North American Auto Industry, Steve Babson 3. Four Models of Cross-Border Maquila Organizing, Henry Frundt 4. Union Global Alliances at Multinational Corporations: A Case Study of the Ameritech Alliance, Jeff Rechenbach and Larry Cohen Part II: Responding to Immigration 5. New Workers, New Labor, and the New Los Angeles, Ruth Milkman 6. Unions and Immigrants in South Florida: A Comparison, Bruce Nissen and Guillermo Grenier Part III: Internal Transformation: Moving Toward Social Movement Unionism? 7. The Strategic Challenge of Organizing Manufacturing Workers in Global/Flexible Capitalism, Fernando Gapasin and Edna Bonacich 8. Does Neoliberal Restructuring Promote Movement Unionism? U.S. Developments in Comparative Perspective, Ian Robinson 9. Citizenship Movement Unionism: For the Defense of Local Communities in the Global Age, Paul Johnston 10. Concluding Thoughts: Internal Transformation? Bruce Nissen
Semi-Supervised Collective Matrix Factorization for Topic Detection and Document Clustering

Topic detection and tracking (TDT) under modern media circumstances has been dramatically innovated with the ever-changing social network and inconspicuous connections among participants in the internet communities. Apart from the inherent word features of analysing materials, such as news articles and personal or professional comments, incidental information attracts increasing attention from the research community. Meanwhile, numerous interrelations hiding in the propagated articles and network participants also promote the transfer and evolvement of topics, not only apparent connections, for example having the same tags and belonging to the same party, but also weak connections which are complicated and with little causal relations. Therefore, answering the question how to exploit and use this hidden information in the social network will extend the landscape of research on TDT. In this paper, we employ the followers' groups extracted from Twitter as the social context that accompanied the corresponding news articles and explore the interior links among them to develop a non-negative factorization methods with semi-supervised information derived from the original data. Furthermore, experiments are conducted on real and semi-synthetic data sets to test the performance of topic detection and documents clustering. The results demonstrate that the proposed method outperforms several state-of-the-art methods.
Working memory and emotion: Detecting the hedonic detector

In an attempt to account for the impact of emotion on cognition, Baddeley (2007) proposed the existence of a hedonic detection system. Malfunctioning of this system was assumed to play a crucial role in depression. Exploring this hypothesis requires a simple and rapid way of assessing the neutral point of proposed hedonic detector. We describe two experiments that aim to develop such a method of investigating this system. Both are based on the assumption that the hedonic judgement of simple stimuli will be influenced by the valence of an induced mood. Experiment 1 showed that a negative mood leads to the more negative evaluation of words than the positive mood. Experiment 2 also includes a neutral condition and the evaluation of words, pictures, and faces. In each case the negative mood led to lower hedonic ratings, whereas no difference was found between neutral and positive moods. Implications for further investigating the hypothetical hedonic detector are discussed.
Identification of LPV models for spatially varying interconnected systems

This paper presents a method for system identification of two dimensional parameter varying systems. The idea of linear parameter varying (LPV) identification for one dimensional causal systems in input-output form is extended to identify two dimensional (2-D) parameter varying systems in input-output form which may be causal, semi-causal or non-causal. The identification method is general in the sense that it can be used to identify systems which may be separable or non-separable. Furthermore, the algorithm explicitly takes boundary conditions into consideration. The effectiveness of the approach is demonstrated by applying it to identify a spatially varying model for a non-uniform beam.
CDKL5/STK9 is mutated in Rett syndrome variant with infantile spasms

Background: Rett syndrome is a severe neurodevelopmental disorder, almost exclusively affecting females and characterised by a wide spectrum of clinical manifestations. Both the classic form and preserved speech variant of Rett syndrome are due to mutations in the MECP2 gene. Several other variants of Rett syndrome have been described. In 1985, Hanefeld described a variant with the early appearance of convulsions. In this variant, the normal perinatal period is soon followed by the appearance of seizures, usually infantile spasms. We have observed two patients with signs of Rett syndrome showing acquired microcephaly and stereotypic midline hand movements. The disease started with generalised convulsions and myoclonic fits at 1.5 months in the first patient and with spasms at 10 days in the other, suggesting a diagnosis of the Hanefeld variant. In these patients, MECP2 point mutations and gross rearrangements were excluded by denaturing high performance liquid chromatography and real time quantitative PCR. The ARX and CDKL5 genes have been associated with West syndrome (infantile spasms, hypsarrhythmia, and mental retardation). Methods: Based on the clinical overlap between the Hanefeld variant and West syndrome, we analysed ARX and CDKL5 in the two girls. Results: We found frameshift deletions in CDKL5 in both patients; one in exon 5 (c.163_166delGAAA) and the other in exon 18 (c.2635_2636delCT). CDKL5 was then analysed in 19 classic Rett and 15 preserved speech variant patients, all MECP2 negative, but no mutations were found. Conclusion: Our results show that CDKL5 is responsible for a rare variant of Rett syndrome characterised by early development of convulsions, usually of the spasm type.
High resolution EKG with USB connectivity

Every hour 8 to 10 Mexicans die because of cardiovascular diseases. The most common pathology is Myocardial Infarction, primarily responsible for deaths throughout of the country, and the leading cause of death in the Baja California state. Those who survive a myocardial infarction are highly likely to suffer Sudden Cardiac Death (SCD) due to the development of malignant ventricular tachycardia. This can be predicted with the detection of so-called Ventricular Late Potentials (VLP) located at the end of the QRS complex and/or at the beginning of the ST segment. The Health Sector in Baja California does not have diagnostic assessment devices that can predict these abnormalities. This document details the progress achieved in the development of a technological package (digital and analog interface for USB communication) capable of capturing, recording and analyzing High-Resolution Electrocardiogram (HRECG). The aim is to predict risk of SCD detecting VLP in infarcted patients in our region using the Classical Time Domain Method and the high resolution electrocardiograph device developed in our lab.
‘Here there is order, full stop!’ – radical reflexivity and teachers’ migrations from the orders of education toward the (dis)orders of (self-)relations

This article derives from a case study involving in-depth interviews of 20 Mexican and Spanish teachers. Testimonies are analysed from teachers engaged in a training programme for ‘radical reflexivity’ known as Seekers After Truth (SAT). This training is informed by theory and practices from the psychotherapeutic and spiritual traditions. Evidence discussed in this article focuses on participating teachers’ positionings within the orders of education, understood as the means through which they organize and orchestrate teaching and learning. The article presents shifts occurring in their teaching practice and frames a discussion of these within Giddens’ analysis of modernity’s simultaneous drive toward ‘abstract systems’ and ‘pure’ relations. It is argued that the SAT’s training in ‘radical reflexivity’, which focuses exclusively on the ‘personal’ rather than the ‘professional’, effectively catalyses migrations in teacher identity, agency and relations. These migrations challenge and compensate for the institutional and individual abstractions that are often experienced as problematic both for teaching and for learning.
Getting in shape: adaptation and phylogenetic inertia in morphology of Australian anuran larvae

The external morphology of frog larvae is predicted to vary among habitats, for a variety of functional reasons. I performed a phylogenetic comparative study to test whether correlations between habitat and the shape of the tadpole and its oral disc are adaptive in 82 species from south‐eastern Australia in the families Hylidae and Myobatrachidae. Habitat distributions and phylogenetic relationships were compiled from the literature and shape was quantified using geometric morphometric analysis of published drawings. Results indicate that shape evolved towards different optima in different habitats while also showing appreciable levels of phylogenetic inertia. Within myobatrachids, evolution of terrestrial tadpoles was associated with a short and shallow head/body and a shallow tail. In aquatic species, the use of benthic microhabitats was correlated with a long shallow tail, dorsal eye position, shallow head/body and ventral mouth with robust jaw sheaths. Even traits with evidence for adaptation evolved slowly in response to habitat shifts, usually requiring ≥10 million years to evolve half‐way to a new optimum. Although these findings support adaptive evolution of tadpole body form, they also highlight a strong influence of ancestral character states and indicate that phenotypes in extant species are partly maladaptive.
Scale Economies and Imperfect Competition in the GTAP Model

The universe of existing CGE models can be divided into 3 broad categories. The first class of models (of which the standard GTAP model is a classic example) emphasizes the static effects of policy related to general equilibrium resource reallocation. The second involves scale economics and imperfect competition and the third involves dynamic accumulation effects. Development of the second class of models has followed a long period during which many of the basic tenants of modern industrial organization theory were integrated into the core of mainstream trade theory. The resulting class of applied models emphasizes procompetitive effects. This paper presents techniques for the incorporation of several stylized representations of scale economies and imperfect competition into the GTAP modeling framework. A numerical example is also provided. Technical Paper Number 14 can be downloaded in PDF format. To print this you will need the Adobe Acrobat Reader. For those interested in replicating the results in this technical paper, an associated zip file [249K] can be downloaded. The zip file includes readme files with detailed instructions.
A delay-time-based inspection model for a two-component parallel system

The delay-time concept has been extensively applied in the field of maintenance modeling and optimization. Previous works have mainly focused on single-component systems and series systems with many components, which are restricted. In this paper, we propose a delay-time-based inspection model for a two-component parallel system and study the optimal inspection interval which minimizes the expected cost per unit time in long run. As a beginning, this paper considers an exponential distribution for the time-to-defect of the components. Numerical examples are presented to illustrate the model. This work will be extended to general parallel systems in the future.
Filtrates of Fresh Tumor Injected Prior to Transplantation of the Homologous Tumor.∗

Summary In 6 experiments involving 66 rabbits, Berkefeld “V”, “N” and Seitz filtrates of fresh Brown-Pearce tumor tissue did not contain evidence of the specific XYZ or lyophilization factor, although the factor has been uniformly present in Berkefeld “V” filtrates of tumor tissue after prolonged freezing
Identification, cDNA Cloning, and Characterization of Luteinizing Hormone Beta Subunit (lhb) Gene in Catla catla

ABSTRACT Reproductive hormones play a significant role in the gonadal development and gametogenesis process of animals. In the present study luteinizing hormone beta, (lhb) subunit gene was cloned and characterized from the brain of Catla catla. The lhb full-length of cDNA sequence is 629 bp which consists of 43bp 5'-UTR (untranslated region) 447bp, ORF(open reading frame) and 139 bp of 3'-UTR respectively. The coding region of lhb gene encoded a peptide of 148 amino acids. The coding sequence of lhb gene consist of a single N-linked glycosylation site (NET) and 12 cysteine knot residues. Phylogenetic analysis of C. catla Lhβ deduced amino acid sequence showed high similarity with Carassius auratus followed by Gobiocypris rarus. 3D structure Lhβ protein comprises of five β-sheets and six coils/loops. The qPCR results revealed lhb mRNA is mainly expressed in the pituitary, ovary while moderate expression was observed in brain and testis. To best our knowledge, this is the first report on the identification, molecular characterization and structural information regarding luteinizing hormone in Indian major carp.
The Northern Ireland Early Onset Psychosis Study: Phenomenology and Co-morbidity in the First 25 Cases

Diagnosing psychotic disorders in young people is difficult. High rates of co-morbidity may be one reason for this difficulty, but it may also be the case that current diagnostic categories are not the most useful when approaching the care of young people with psychotic symptoms. The Northern Ireland Early Onset Psychosis Study is the first study to investigate psychotic disorders in children and adolescents in this region. Young people presenting with psychotic symptoms with onset before their 18th birthday were prospectively ascertained over a three-year period (2001–2004). Those who provided informed consent were subject to a diagnostic interview using the Kiddie-Schedule for Affective Disorders and Schizophrenia—Present and Lifetime Version. Twenty-five young people have completed the full assessment process to date. Ten young people met criteria for schizophrenia, 11 for affective psychosis, two for schizoaffective disorder and two for schizophreniform disorder. Twenty-one (80%) subjects also fulfilled criteria for at least one other DSM-IV diagnosis. In conclusion, whilst all subjects met criteria for one or other psychotic disorder, co-morbidity was common in this clinical sample. Greater awareness of the difficulties encountered when trying to reach a diagnosis in this age group may help to improve treatment outcomes.