Miracle-dz/UniFAR-FTUs huggingface dataset:
Successful Transvenous Embolization of Brain Arteriovenous Malformations Using Onyx in Five Consecutive Patients

BACKGROUND:There is an increasing application of endovascular treatment for brain arteriovenous malformations (BAVMs) using ethylene vinyl alcohol copolymer (Onyx). Historically, this treatment has been performed using a transarterial approach. OBJECTIVE:To report our experience with transvenous endovascular embolization with Onyx (TVEO). METHODS:Five consecutive patients with BAVMs underwent endovascular TVEO between June 2007 and March 2009 at the Interventional Neuroradiology Department of the University Hospital of Limoges. There were 3 men and 2 women with a mean age of 41.8 years (range, 19-57 years). The clinical presentation included symptoms caused by intracerebral hemorrhage (n = 4) and seizures (n = 1). According to the Spetzler-Martin classification scheme, 3 BAVMs (60%) were grade III, and 2 BAVMs (40%) were grade IV. Four BAVMs (80%) were supratentorial and 1 BAVM (20%) was infratentorial. Immediate and mid-term treatment (6 months) outcomes were angiographically and clinically analyzed according to the modified Rankin Scale. RESULTS:The transvenous approach was used in all patients (100%). The success rate of complete obliteration of the arteriovenous malformation nidus was 80% (4 of 5), confirmed by follow-up angiography performed immediately and at 6 months after TVEO. No procedure-related complications occurred during or after embolization. All patients remained unchanged (modified Rankin Scale score = 0-2) and clinically stable 6 months after TVEO. CONCLUSION:The transvenous approach using Onyx for the management of BAVMs is shown to be an efficient and safe alternative treatment in cases with no other conventional therapeutic choice and when some anatomic considerations are respected.
Spatial Categorization and Computation - Empirical Evidence from Artificial Label

It is well known that spatial perception is a basic ability in our daily life, while we compute spatial relationship between two objects universally. This study examined how people perceive spatial categories using three tasks, learning task, producing task, and rating task. Three different kinds of spatial configurations were manipulated. 27 subjects were assigned randomly to each kind of spatial configuration. The results showed that response times(RTs) for spatial category judgment were, just as we have expected, slower near the boundary and faster near prototype, in learning task. RT pattern, in rating task, also suggested that people formed the expected configurations. People’s rating patterns were well captured the spatial configurations predefined. Performances in all three tasks suggested that people can form artificial spatial categories and make spatial computation with enough practices. Implication for Bayesian analysis and application were briefly discussed.
Somatization among older primary care attenders

Background. The importance of somatization among older primary care attenders is unclear. We aimed to establish the prevalence, persistence and associations of somatization among older primary care attenders, and the associations of frequent attendance. Method. One hundred and forty primary care attenders over 65 years were rated twice, 10 months apart, on measures of somatization, psychiatric status, physical health and attendance. Results. The syndrome of GMS hypochondriacal neurosis had a prevalence of 5% but was transient. Somatized symptoms and attributions were persistent and associated with depression, physical illness and perceived poor social support. Frequent attenders (top third) had higher rates of depression, physical illness and somatic symptoms, and lower perceived support. Conclusion. Somatization is common among older primary care attenders and has similar correlates to younger primary care somatizers. Psychological distress among older primary care attenders is associated with frequent attendance. Improved recognition should result in benefits to patients and services.
The Impact of Mobile Phone Uses in the Developing World: Giving Voice to the Rural Poor in the Congo

In recent years, the rise of information and communication technologies (ICTs) contrasted with the dire living conditions of the world’s poorest has been the subject of debate among industry and academia. However, despite the amount of writings produced on mobile phones, Western bias is surprisingly unbridledly prevailing alongside the feted dissemination of mobile phones. Expansive literature tends to present the rapid adoption of mobile phones among rural individuals, with little to no indication of how local values and voices are respected or promoted. We undertook semi-structured interviews with 16 rural chiefs to inquire into ways in which mobile phones enabled socio-economic development in the rural Congo. Rather than using quantitative, large-scale, or top-down data, we sought to give voice to chiefs themselves about the role of mobile phones. We found that Western bias dominates the literature and deployment of mobile phones more than usually acknowledged. We suggested some paths forward, while bringing the African communal Utu or Ubuntu culture to the center stage.
Extracción de Opiniones sobre Características: Un Enfoque Práctico Adaptable al Dominio.

En el contexto de la Web 2.0, las opiniones volcadas por los usuarios a traves de las redes sociales, foros y otros servicios, acerca de productos, politica u otras tematicas, conforman una interesantisima informacion con un gran potencial practico de cara a l . as empresas, las administraciones y los ciudadanos. Siendo el texto libre el principal vehiculo de dicha informacion en Internet, las Tecnologias del Lenguaje y el Procesamiento del Lenguaje Natural ocupan un papel protagonista de cara al tratamiento y analisis automatico de la misma. De manera mas concreta, recientemente diversos investigadores se han venido ocupando del tratamiento computacional de las opiniones, los sentimientos y otros fenomenos subjetivos del lenguaje. Dentro de esta disciplina, en el presente trabajo de tesis abordamos el problema de la extraccion de opiniones sobre caracteristicas, tarea cercana a la extraccion de informacion y consistente en extraer representaciones estructuradas de las opiniones individuales contenidas en los textos, incluyendo la identificacion de las caracteristicas concretas del objeto sobre las que se vuelcan las opiniones, y la polaridad positiva o negativa de dichas opiniones. Los aspectos fundamentales de nuestro acercamiento son dos: la consideracion del dominio de aplicacion en cada una de las fases de la resolucion del problema, y el uso de taxonomias de caracteristicas, que permiten que el conjunto de opiniones extraidas sean facilmente agregables y visualizables.En la presente memoria, definiremos un conjunto de recursos de apoyo a la tarea de extraccion de opiniones sobre caracteristicas, adaptables al dominio; propondremos una metodologia para la generacion de los mismos, proporcionando las herramientas y algoritmos necesarios para minimizar la participacion manual en el proceso; y describiremos un sistema de extraccion de opiniones sobre caracteristicas modular y adaptable al dominio, al que hemos denominado TOES (Taxonomy-based Opinion Extraction System). Los resultados de la experimentacion que llevaremos a cabo nos permitian afirmar la importancia del dominio en el problema que nos ocupa, y la utilidad de las opiniones extraidas de cara a una aplicacion de agregacion y visualizacion de opiniones.
Delineation of nevus cell nests in inflammatory infiltrates by immunohistochemical staining for the presence of S100 protein

Fifteen halo nevi were stained for the presence of S100 protein by an unlabelled antibody peroxidase‐antiperoxidase method. SUM) protein was clearly identifiable within nevus cell nests in the inflammatory infiltrate. The presence of this substance helped to identify nevus cells in dense inflammatory infiltrates and confirm the histologic diagnosis of halo nevus.
The organizational pendulum

In recent years, there have been a number of large-scale changes in the organization of healthcare in Sweden, as in many other countries. From a longer time perspective, however, there has been a more or less permanent oscillation between centralization and decentralization, and also between competition and co-operation, in Swedish healthcare organizations. In fact, there seems to be something like a pendulum moving all the time between opposite forms of organization. The frequency of these changes has been increasing during the last fifteen years, as different organizational models have replaced each other at shorter and shorter intervals. This development is partly due to the increasing rate of change in modern society, but partly also due to an element of fashion in the area of management. There is, however, a growing change fatigue in many healthcare organizations, and also increasing demands for empirical evidence on the efficiency and effectiveness of different organizational models before they are introduced into the healthcare system.
NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

ABSTRACT Accumulating evidence implicates the transcription factor NF-κB as a positive mediator of cell growth, but the molecular mechanism(s) involved in this process remains largely unknown. Here we use both a skeletal muscle differentiation model and normal diploid fibroblasts to gain insight into how NF-κB regulates cell growth and differentiation. Results obtained with the C2C12 myoblast cell line demonstrate that NF-κB functions as an inhibitor of myogenic differentiation. Myoblasts generated to lack NF-κB activity displayed defects in cellular proliferation and cell cycle exit upon differentiation. An analysis of cell cycle markers revealed that NF-κB activates cyclin D1 expression, and the results showed that this regulatory pathway is one mechanism by which NF-κB inhibits myogenesis. NF-κB regulation of cyclin D1 occurs at the transcriptional level and is mediated by direct binding of NF-κB to multiple sites in the cyclin D1 promoter. Using diploid fibroblasts, we demonstrate that NF-κB is required to induce cyclin D1 expression and pRb hyperphosphorylation and promote G1-to-S progression. Consistent with results obtained with the C2C12 differentiation model, we show that NF-κB also promotes cell growth in embryonic fibroblasts, correlating with its regulation of cyclin D1. These data therefore identify cyclin D1 as an important transcriptional target of NF-κB and reveal a mechanism to explain how NF-κB is involved in the early phases of the cell cycle to regulate cell growth and differentiation.
Digital Refocusing: All-in-Focus Image Rendering Based on Holoscopic 3D Camera

This paper presents an innovative method for digital refocusing of different point in space after capturing and also extracts all-in-focus image. The proposed method extracts all-in-focus image using Michelson contrast formula hence, it helps in calculating the coordinates of the 3D object location. With light field integral camera setup the scene to capture the objects precisely positioned in a measurable distance from the camera therefore, it helps in refocusing process to return the original location where the object is focused; else it will be blurred with less contrast. The highest contrast values at different points in space can return the focused points where the objects are initially positioned as a result; all-in-focus image can also be obtained. Detailed experiments are conducted to demonstrate the credibility of proposed method with results.
Paradigm Resolution in the Life Cycle of Norse Umlaut

This paper follows on recent work (Iverson & Salmons 2004, 2007; Kiparsky 2005, 2006) seeking to resolve Kock's 1888 paradox intro-duced in his celebrated “period theory” of Old Norse i-umlaut. The basic finding is this: In paradigms where a phonological innovation has been rendered opaque by the operation of other sound changes, restructuring of the base form incorporates rather than derives the results of the innovation as it dies out; but if the innovation remains transparent in certain other paradigms, its expiration enables reversion to the antecedent phonological form. Both patterns can be subsumed under the traditional rubric of analogy, resulting in allomorphically uniform paradigms, but the former generalizes a sound change to con-texts in which it never occurred naturally, whereas the latter actually undoes, or reverses, a sound change. *
A randomized‐controlled trial comparing an educational intervention alone vs education and biofeedback in the management of faecal incontinence in women

Abstract Biofeedback (BF) training is an accepted therapy in the treatment of faecal incontinence (FI) despite a paucity of data demonstrating benefit. This study aims to determine whether BF has any specific effect above and beyond an educational intervention. Twenty‐three women with regular and frequent idiopathic FI were randomized to education and pelvic exercise vs education and BF therapy. Complete data is available for 18 women. Overall, 61% of participants demonstrated a complete response. There was no difference in response rate between treatment arms. Women with FI demonstrate a good response to treatment with education and exercise and education plus BF thus questioning the specific effect of BF.
Holistic Nurses’ Use of Energy-Based Caring Modalities

As part of a study of a larger study of self-identified holistic nurses, researchers asked nurses to describe practice situations where energy-based modalities (EBMs) were used. Four hundred and twenty-four nurses responded by writing free-text responses on an online survey tool. The participants were highly educated and very experienced with 42% holding graduate degrees and 77% having over 21 years of practice. Conventional content analysis revealed four themes: EMBs are 1) caring modalities used to treat a wide range of identified nursing concerns; 2) implemented across the life span and to facilitate life transitions; 3) support care for the treatment of specific medical conditions; and 4) Use of EBMs transcend labels of ‘conditions’ and are used within a holistic framework. The fourth theme reveals a shared vision of nursing work such that the modality becomes secondary and the need to address the ‘whole’ at an energetic level emerges as the primary focus of holistic nursing.
Modelling and analysis of coordination of a three-level supply chain with use of price discount along with delay in payment

Coordination improves the performance of a supply chain system. Two popular coordination mechanisms are 'price discount' and 'delay in payment'. The effect of these two mechanisms individually on supply chain performance has already been reported in literature. In this work, the two mechanisms 'price discount' and 'delay in payment' are used simultaneously to coordinate a three-level supply chain system. The problem has been modelled mathematically and solved. The result obtained in the case is compared with that obtained when using 'price discount' alone. It is seen that use of 'price discount' along with 'delay in payment' enhances the supply chain profit significantly compared to the case of price discounts alone.
Terminology expansion and re-lation identification between genes and path-ways

A hand manipulated tool or implement used to open shell-fish such as oysters, clams or the like and including first and second leg means having appropriate handles arranged in corresponding position thereon wherein the second leg means is pivotally attached to the first leg means at a point intermediate a blade portion of the first handle means. A curvilinear or arcuate portion is formed on the second handle means and includes a roughened or serrated edge used to grip the object being opened wherein the cutting edge of the blade and the serrated portion are substantially co-planar with one another so as to easily separate shellfish or the like.
Sistema baseado em regras para o refinamento da segmentação automatica de fala

A demanda por uma segmentacao automatica de fala confiavel vem crescendo e exigindo pesquisas para suportar o desenvolvimento de sistemas que usam fala para uma interacao homem-maquina. Neste contexto, este trabalho relata o desenvolvimento e avaliacao de um sistema para segmentacao automatica de fala usando o algoritmo de Viterbi e refinamento das fronteiras de segmentacao baseado nas caracteristicas fonetico-acusticas das classes foneticas. As subunidades foneticas (dependentes de contexto) sao representadas com Modelos Ocultos de Markov (HMM - Hidden Markov Models). Cada fronteira estimada pelo algoritmo de Viterbi e refinada usando caracteristicas acusticas dependentes de classes de fones, uma vez que a identidade dos fones do lado direito e esquerdo da fronteira considerada e conhecida. O sistema proposto foi avaliado usando duas bases dependentes de locutor do Portugues do Brasil (uma masculina e outra feminina) e tambem uma base independente de locutor (TIMIT). A avaliacao foi realizada comparando a segmentacao automatica com a segmentacao manual. Depois do processo de refinamento, um ganho de 29% nas fronteiras com erro de segmentacao abaixo de 20 ms foi obtido para a base de fala dependente de locutor masculino do Portugues Brasileiro Abstract
Multiplex SNP‐SCALE: a cost‐effective medium‐throughput single nucleotide polymorphism genotyping method

We describe a convenient, cost‐effective and flexible medium‐throughput single nucleotide polymorphism (SNP) genotyping method, Multiplex SNP‐SCALE, which enables the simultaneous amplification by polymerase chain reaction (PCR) of up to 25 (or potentially more) loci followed by electrophoresis in an automated DNA sequencer. We extended the original SNP‐SCALE method to include (i) use of a commercial multiplex PCR kit, (ii) a four‐dye system, (iii) much‐reduced (2‐µL) reaction volumes, (iv) drying down of template DNA before PCR, (v) use of pig‐tailed primers, (vi) a PCR product weighting system, (vii) a standard optimized touchdown PCR thermocycling programme, and (viii) software (SNP‐SCALE Primer Designer) that automatically designs suitable SNP‐SCALE primers for a batch of loci. This new protocol was validated for different types of SNPs. The method is cost‐ and time‐effective for medium‐scale evolutionary and ecological projects involving 10s to 100s of loci.
Quantification of Different Transferrin Receptor Pools in Primary Cultures of Porcine Blood‐Brain Barrier Endothelial Cells

Abstract: Distribution of iron in the brain varies with region, cell type, and age. Furthermore, some neurological diseases are accompanied by an abnormal accumulation of iron in specific areas of the CNS. These findings implicate a mobile intracerebral iron pool; however, transport of iron across the blood‐brain barrier and its regulation are largely unknown. In an extensive series of experiments in primary cultures of porcine blood‐brain barrier endothelial cells, we separately quantified surface‐bound and total cellular transferrin receptor pools. Although 90% of all transferrin receptors were located inside the cell, only 10% of these intracellular receptors actively took part in the endocytic cycle. This large “inactive” intracellular transferrin receptor pool could either function as a storage site for spare receptors or be activated by the cell to increase its capacity for iron transport. Data were corrected for nonspecific binding by a separate biochemical assessment using a 100‐fold excess of unlabeled ligand. Data were also analyzed in a nonlinear curve‐fit program. This resulted in a less elaborate and less biased estimate of nonspecific binding.
A 1-Year Study to Compare the Efficacy and Safety of Once-Daily Travoprost 0.004%/Timolol 0.5% to Once-Daily Latanoprost 0.005%/Timolol 0.5% in Patients with Open-Angle Glaucoma or Ocular Hypertension

Purpose The objective of the study was to compare the intraocular pressure (IOP)-lowering efficacy and safety of travoprost 0.004%/timolol 0.5% ophthalmic solution (Trav/Tim) to latanoprost 0.005%/timolol 0.5% ophthalmic solution (Lat/Tim), dosed once daily in the morning, in patients with open-angle glaucoma (OAG) or ocular hypertension (OH). Methods This was a randomized, double-masked, multicenter, parallel group, active-controlled study conducted at 41 sites. At the eligibility visit the patients were randomized (1:1) to the assigned masked medication if they met inclusion/exclusion criteria, and the mean IOP values in the eligible eyes were ≥24 mmHg at 9 AM and ≥21 mmHg at 11 AM and 4 PM. Patients were excluded if the mean IOP in either eye was >36 mmHg. Patients were instructed to administer the assigned medication each morning at 9 AM. During the treatment phase of the study, IOP was measured at 9 AM at week 2, week 6, month 3, and month 9. At the month 6 and month 12 visits, IOP was measured at 9 AM, 11 AM, and 4 PM. Statistical methods included a repeated measures analysis of variance (ANOVA); to test for noninferiority, a 95% confidence interval for the treatment group difference was constructed based on the ANOVA results for each time point at month 12. Results Patients (n=408) with OAG or OH were enrolled at 41 sites. One patient withdrew prior to receiving medication so 207 in the Trav/Tim group and 200 in the Lat/Tim group were evaluable for safety. Baseline demographic characteristics as well as IOP values showed no statistical differences between the two groups. Trav/Tim provided lower mean IOP values than Lat/Tim that were statistically significant at the week 2 9 AM (p=0.0081), month 6 9 AM (p=0.0056), and month 6 11 AM (p=0.0128) time points and at 9 AM time point pooled across all visits (p=0.0235) when mean IOP was 0.6 mmHg lower in the Trav/Tim group. Treatment-related adverse events were mild in both groups. Although hyperemia was reported from a higher percentage of patients in Trav/Tim group, differences in average hyperemia scores between the two groups were not considered clinically relevant. Conclusions Travoprost 0.004%/timolol 0.5% ophthalmic solution produced mean IOP levels that are statistically noninferior to latanoprost 0.005%/timolol 0.5% ophthalmic solution. Furthermore, at 9:00 AM, 24 hours after dosing, IOP was statistically lower for travoprost 0.004%/timolol 0.5% pooled across all visits. Travoprost 0.004%/timolol 0.5% fixed combination ophthalmic solution is an effective treatment for reducing IOP and it is safe and well-tolerated in patients with OAG or OH. (Eur J Ophthalmol 2007; 17: 183–90)
A comparison of two methods of estimating propensity scores after multiple imputation-online supplement

In the online supplement we present details of additional simulations and results that have been referred to in the main text of the paper. In Appendix 1 we present results of the treatment effect estimates from the Across and Within methods in the simulations of Section 3 when matching is performed with replacement. In Appendix 2 we investigate different applications of propensity scores to estimate treatment effects in the simulations of Section 3. In Appendix 3 we present the results of a logistic regression of treatment assignment on the covariates for the 1306 complete cases in the National Longitudinal Survey of Youth (NLSY) data before introduction of missing values.