Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of the Revised International Staging System in an independent cohort of unselected patients with multiple myeloma

The Revised International Staging System (R-ISS) was recently introduced in order to improve risk stratification over that provided by the widely used standard International Staging System. In addition to the parameters of the standard system, the R-ISS incorporates the presence of chromosomal abnormalities detected by interphase fluorescence in situ hybridization [t(4;14), t(14;16) and del17p] and elevated serum lactate dehydrogenase. The R-ISS was formulated on the basis of a large dataset of selected patients who had participated in clinical trials and has not been validated in an independent cohort of unselected patients. Thus, we evaluated the R-ISS in 475 consecutive, unselected patients, treated in a single center. Our patients were older and more often had severe renal dysfunction than those in the original publication on the R-ISS. As regards distribution by group, 18% had R-ISS-1, 64.5% R-ISS-2 and 18% R-ISS-3. According to R-ISS group, the 5-year survival rate was 77%, 53% and 19% for R-ISS-1, -2 and -3, respectively (P<0.001). The R-ISS could identify three groups with distinct outcomes among patients treated with or without autologous stem cell transplantation, among those treated with either bortezomib-based or immunomodulatory drug-based primary therapy and in patients ≤65, 66–75 or >75 years. However, in patients with severe renal dysfunction the distinction between groups was less clear. In conclusion, our data in consecutive, unselected patients, with differences in the characteristics and treatment approaches compared to the original International Myeloma Working Group cohort, verified that R-ISS is a robust tool for risk stratification of newly diagnosed patients with symptomatic myeloma.
Symmetry and hierarchy in social mobility: a methodological analysis of the CASMIN model of class mobility.

The CASMIN model of class mobility proposed by Erikson and Goldthorpe advances our understanding of cross-national differences in social mobility in a number of important ways most notably by showing how differences in the association between social origins and destinations reflect consequences of public policies that enhance or restrict opportunities. We respecify the CASMIN model in ways that clarify (a) the role of socioeconomic differences among classes in mobility processes and (b) the extent of cross-national variation. In particular the problems with the CASMIN model are its application to highly aggregated occupational classes its suppression of hierarchical or vertical differences among classes and its asymmetric classification of origin and destination classes. Our alternative specification is based on greater occupational detail incorporates continuous covariates in linear-by-linear expressions that are analogous to regression models and imposes symmetry on the association between origins and destinations. We find that the CASMIN model understates the importance of hierarchy relative to sector and inheritance in the determination of mobility patterns generally as well as in cross-national differences. Furthermore the symmetry of our model facilitates the analysis of structural mobility as a factor that contributes to cross-national differences in overall mobility rates. (authors)
Renal Medullary Carcinoma: Molecular, Immunohistochemistry, and Morphologic Correlation

Renal medullary carcinoma, a highly aggressive tumor mainly occurring in patients with sickle cell hemoglobinopathy, is characterized by advanced stage at the time of presentation and poor response to treatment. Currently, the pathogenesis of this tumor is not well understood. In this study, the clinicopathologic features and molecular changes of 15 renal medullary carcinoma cases were evaluated. These cases demonstrated male predominance (M:F=2:1) with a median age of 26 years. The tumors occurred predominantly in the right kidney with an average size of 5.9 cm. Immunohistochemistry analysis showed that the neoplastic cells were positive for CEA (7/8), AE1/3 (8/8), CAM5.2 (7/7), CK7 (5/5), CK20 (4/6), and vimentin (6/6). Absence of SMARCB1 protein expression in tumor cells was demonstrated in all of the 7 cases analyzed. By polymerase chain reaction–based microsatellite analysis, loss of heterozygosity of SMARCB1 was identified in 9 of 10 cases. These data suggest that inactivation of SMARCB1 may play a role in the pathogenesis of renal medullary carcinoma.
Antioxidant and antimicrobial activity of ethanol and water extracts of Cymbopogon jwarancusa (Jones.) leaves

The Cymbopogon jwarancusa (Jones.) leaves extracts were explored for their antioxidant and antimicrobial activity. The ethanol extract showed highest antioxidant activity in DPPH (31.99 ± 0.50 % inhibition) and FRAP (38.79 ± 0.54 Fe (II) micromole per litre) assay while water extract showed highest antioxidant activity in βCL (54.76 ± 1.37 %) at 1mg/10ml concentration. BHT and ascorbic acid were used as standards. During antimicrobial assay, the ethanol extract found was very effective against Fusarium oxyporium f.sp-lini (85.31 ± 0.25 mm) and Staphylococcus aureus (94.37 ± 0.28 mm) at 500 ppm while water extract was found less effective against Aspergillus flavus (03.72 ± 0.19 mm) at 100 ppm concentration. The ethanol extract can be used for the applications such as food preservation as a remedy and against dental diseases.
On Porting iperf to Windows Mobile and Adding BlueTooth Support

This paper presents high-level details of two contributions to iperf, a modern tool for testing network performance. The flrst contribution is a port of the tool to the Windows Mobile operating system, while the second one is the extension of the tool to support BlueTooth communication. The paper also includes results of experiments carried out by the modifled tool in various conflgurations of real networks created by laptops and mobile phones.
Clonal patterns of cell proliferation, migration, and dispersal in the brainstem of the chicken embryo

Retroviral-mediated gene transfer was used to study clonal patterns of proliferation, migration, and dispersal in the brainstem of the chicken embryo. Clones were generated at stages 13–17 (Hamburger and Hamilton, 1951), a period of neurogenesis in the brainstem neural tube subsequent to the formation of rhombomeres. Clones were examined in separate experiments at stages 24–27, when many neurons migrate and differentiate; at stages 28–29, when brainstem nuclei begin to form; and at stages 34–35, when brainstem nuclei are fully formed. Stages 24– 29 are characterized by a general variability in proliferative kinetics and migratory behavior. Clone sizes range from 1 to 29 cells, and migration patterns range from strictly radial (i.e., normal to the ventricular surface) to combined radial and tangential (i.e., perpendicular to the radial component). There is, however, an underlying systematic variation: (1) clones exhibiting tangential migration contain on average more cells than clones exhibiting only radial migration, and (2) the proportion of tangentially migrating clones increases from medial to lateral. By stages 34–35 some individual clones have apparently dispersed to disparate neuronal groups. The regional diversity observed among clones suggests that position along the mediolateral axis may determine the proliferative potential of progenitors and the migratory behavior and subsequent dispersal of their descendants.
Concurrent Volume Visualization of Real-Time fMRI

We present a novel approach to interactive and concurrent volume visualization of functional Magnetic Resonance Imaging (fMRI). While the patient is in the scanner, data is extracted in real-time using state-of-the-art signal processing techniques. The fMRI signal is treated as light emission when rendering a patient-specific high resolution reference MRI volume, obtained at the beginning of the experiment. As a result, the brain glows and emits light from active regions. The low resolution fMRI signal is thus effectively fused with the reference brain with the current transfer function settings yielding an effective focus and context visualization. The delay from a change in the fMRI signal to the visualization is approximately 2 seconds. The advantage of our method over standard 2D slice based methods is shown in a user study. We demonstrate our technique through experiments providing interactive visualization to the fMRI operator and also to the test subject in the scanner through a head mounted display.
Comparative phylogeographic study of Hosta sieboldiana and Hosta albomarginata (Asparagaceae) in Japan

We analyzed variations in chloroplast DNA (cpDNA) in the widespread herbaceous species Hosta sieboldiana and Hosta albomarginata across large portions of their geographic ranges in the Japanese archipelago. Our objective was to compare the phylogeographic histories and phylogeographic structures of the two congeneric species in the Japanese archipelago. The location of the study is Japanese archipelago. We sequenced 1380 bp of noncoding cpDNA from 45 populations of H. sieboldiana (n = 362) and 55 populations of H. albomarginata (n = 436) to assess genetic variations within and among populations across almost the entire distributions of the species in Japan. Extant patterns of geographic structure were analyzed using statistical parsimony networks and spatial analysis of molecular variance (SAMOVA). We also used Monmonier's algorithm to detect genetic barriers between regions. Relationships between the populations were examined using a neighbor-joining (NJ) method. Four haplotypes were found for H. sieboldiana, whereas eight haplotypes were identified for H. albomarginata. Total genetic haplotype diversity (hT) and within-population haplotype diversity (hS) for H. sieboldiana were 0.352 and 0.040, respectively, while the values for H. albomarginata were 0.529 and 0.085, respectively. The population differentiations (GST) for H. sieboldiana and H. albomarginata were 0.839 and 0.886, respectively. The SAMOVA analysis revealed two clusters in H. sieboldiana and four clusters in H. albomarginata. Differentiations between and among the clusters were supported by the BARRIER analysis and the NJ tree. We detected differences in the population genetic structure between the two species. We found that H. sieboldiana had lower haplotype diversity than H. albomarginata. These results may be partially explained by the difference in ecological habitats and geographic distributions between the species. Hosta albomarginata is more widely distributed than H. sieboldiana in East Asia including Russia, and this large distribution range would enable more chances to intraspecific gene flow.
The social construction of gay oppression as a determinant of gay men's health: ‘homophobia is killing us’

Where once the health sciences concentrated much of their efforts on curing homosexuality, contemporary health science is concerned largely with the mental and physical effects of oppression, which are now taken as the legitimate focus of health research and intervention. However, gay men's health has imported into its practice a fairly individualistic ideology, one that undermines efforts to address the social determinants of health and to achieve social justice goals. In this article, I explore the social construction of gay men's health in the health literature. My analysis focuses specifically on constructions of gay oppression as a determinant of health. Through an analysis of the gay men's health literature, I identify three recurring themes: (i) gay oppression is conceived as a psychological phenomenon, (ii) gay men's damaged psychologies are a determinant of gay men's health, and (iii) individual therapies are proposed as the solution to gay oppression. Like mainstream health research and practice, gay men's health focuses attention on the mental and physical functioning of the individual, ignores the social and structural determinants of health, and directs health intervention squarely on the individual. I propose an alternative (anti-oppression) research agenda; one that shifts our conceptualisation of the ‘the problem’ from the oppressed to the oppressor.
Heritable Stochastic Switching Revealed by Single-Cell Genealogy

The partitioning and subsequent inheritance of cellular factors like proteins and RNAs is a ubiquitous feature of cell division. However, direct quantitative measures of how such nongenetic inheritance affects subsequent changes in gene expression have been lacking. We tracked families of the yeast Saccharomyces cerevisiae as they switch between two semi-stable epigenetic states. We found that long after two cells have divided, they continued to switch in a synchronized manner, whereas individual cells have exponentially distributed switching times. By comparing these results to a Poisson process, we show that the time evolution of an epigenetic state depends initially on inherited factors, with stochastic processes requiring several generations to decorrelate closely related cells. Finally, a simple stochastic model demonstrates that a single fluctuating regulatory protein that is synthesized in large bursts can explain the bulk of our results.
Chemical synthesis and expression in yeast of a gene encoding connective tissue activating peptide-III. A novel approach for the facile assembly of a gene encoding a human platelet-derived mitogen.

A synthetic gene encoding the platelet-derived factor, connective tissue activating peptide-III (CTAP-III) (Castor, C.W., Miller, J.W., and Walz, D.A. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 765-769), has been expressed and secreted from Saccharomyces cerevisiae by using a yeast expression vector and an alpha-factor leader segment. Mitogenic activity reported for naturally derived CTAP-III has been demonstrated here for recombinant CTAP-III. Active CTAP-III has been purified to apparent homogeneity. Structural studies have confirmed its identity. A general approach for the facile synthesis of genes is presented which has permitted the assembly of the entire structural gene and flanking regions (280 base pairs) from 20 oligomers in a single annealing and ligation reaction pool.
Collaborative Web Service QoS Prediction via Neighborhood Integrated Matrix Factorization

With the increasing presence and adoption of web services on the World Wide Web, the demand of efficient web service quality evaluation approaches is becoming unprecedentedly strong. To avoid the expensive and time-consuming web service invocations, this paper proposes a collaborative quality-of-service (QoS) prediction approach for web services by taking advantages of the past web service usage experiences of service users. We first apply the concept of user-collaboration for the web service QoS information sharing. Then, based on the collected QoS data, a neighborhood-integrated approach is designed for personalized web service QoS value prediction. To validate our approach, large-scale real-world experiments are conducted, which include 1,974,675 web service invocations from 339 service users on 5,825 real-world web services. The comprehensive experimental studies show that our proposed approach achieves higher prediction accuracy than other approaches. The public release of our web service QoS data set provides valuable real-world data for future research.
catena-Poly[[(2-amino-1,3-benzothiazole-6-carboxylato-κ2 O,O′)(2,2′-bipyridyl-κ2 N,N′)cadmium]-μ-2-amino-1,3-benzothiazole-6-carboxylato-κ3 N 1:O,O′]

In the title coordination polymer, [Cd(C8H5N2O2S)2(C10H8N2)]n, the CdII ion is coordinated by a bidentate 2,2-bipyridyl ligand, two O,O′-chelating 2-amino-1,3-benzothiazole-6-carboxylate (ABTC) ligands and one N-bonded ABTC ligand. The resulting CdN3O4 coordination polyhedron approximates to a very distorted pentagonal bipramid with one O and one N atom in axial positions. One of the ABTC ligands is bridging to an adjacent metal atom, generating an infinite chain propagating in [100]. A three-dimensional network is constructed from N—H⋯O and N—H⋯N hydrogen bonds and aromatic π–π stacking interactions [centroid–centroid separations = 3.641 (2) and 3.682 (3) Å].
Accounting as a Critical Social Science

Critical theory is concerned with enhancing individual wellbeing and autonomy through societal critique that has its origins in philosophy, sociology and political economics. Critical social science is the application of a critical theoretic within a social‐science domain. Accounting is a technology but it is not ideologically sterile. Critical social science applies critical‐theory methodology in order to make evident the ideological base of manifestations in social science as they lead to alienation, oppression and emancipation. This critical social science critique is applied in order to make evident the ideological base of such manifestations in, or related to, accounting.
What At-Risk Readers Need

Few students in the United States read at a desirable level. According to National Assessment of Educational Progress (NAEP) scores, roughly one-third of U.S. students read at or above the proficient level, one-third read at the basic level, and one-third read at the below basic level (Rampey, Dion, & Donahue, 2009). In other words, two of every three students in U.S. schools have reading proficiencies below the level needed to adequately do grade-level work.
Relabelling or new Approach: theoretical insights regarding Personnel Management and Human Resource Management

The business challenges like globalization, profitability through growth, technology integration, intellectual capital management, continuous change influence not only the way the organizations are structured and managed, but also determine the language of management. As a result some terms emerge and other terms are rejected. However, to what extent the development of the language signify the difference between old and new terms? The question concerning just relabeling or repackaging old things is relevant in the scientific literature. A debate about changing the terminology from „personnel management“ to „human resource management“ attracted huge attention among scientists (Guest, 1987; Clark, 1993; Legge, 1995; Henry and Pettigrew, 1990, Torrington, 1989; Armstrong, 2000; Cakar, Bititci & MacBryde, 2003; Boselie, Brewster & Paauwe, 2009) underlying the “rhetoric” of human resource academics and the “reality” in the organizations. The paper starts with the development of human resource management concept, emphasising that the 1980s and 1990s are the time of the significant change in the context and content of the way in which people were managed. Drawing to the prior research, the paper identifies three main stages in the process of human resource management formation. Acknowledging that human resource management concept is controversial (Storey, 1995), the paper presents two approaches as regards personnel management (PM) and human resource management (HRM): some scientists highlight the revolutionary nature of HRM (Legge, 1989, 1995; Keenoy, 1990; Storey, 1993; Guest, 1987, 1990; Hope-Hailey et al., 1997), meanwhile others (Torrington, 1989; Armstrong, 2000) deny the relevant difference in the concepts of PM and HRM. Seeking to provide the answer to the question – does HRM differ from PM? – the paper attempts to provide the definitions of HRM, however states that a widely acknowledged definition of HRM does not exits, although the definitions of HRM disclose four HRM dimensions: high commitment, high quality, flexibility and strategic integration. To better reveal the nature of HRM, the paper provides some insights on the similarities of PM and HRM highlighting that some of similarities are viewed in the literature as differences also. Finally assessing that the differences between PM and HRM can be seen as a matter of emphasis (Armstrong, 2006), the main differences of the concepts are presented in this paper. This brings to conclusion that in the scientific literature the distinction was made between PM and HRM and the term “human resource management” is now mainly used as synonyms for “personnel management”. DOI: http://dx.doi. org/10.5755/j01.ee. 24.3. 1618
Countertransference, supervision and the reflection process

This paper is concerned with the central importance of countertransference in the helping process, and with the role of supervision in helping therapeutically oriented workers to understand and make use of their own emotional responses to the client. The perils of being drawn into some kind of defensive "acting out" with the client are discussed. Case material is used to illustrate (a) the impact of the client's projections on the worker, and (b) the way in which supervision may itself become the arena for a "reflection" or re-enactment of an object-relationship from the client's internal world.
Nationwide Surveillance of Influenza during the Pandemic (2009–10) and Post-Pandemic (2010–11) Periods in Taiwan

Introduction Although WHO declared the world moving into the post-pandemic period on August 10, 2010, influenza A(H1N1) 2009 virus continued to circulate globally. Its impact was expected to continue during the 2010–11 influenza season. This study describes the nationwide surveillance findings of the pandemic and post-pandemic influenza periods in Taiwan and assesses the impact of influenza A(H1N1) 2009 during the post-pandemic period. Methods The Influenza Laboratory Surveillance Network consisted of 12 contract laboratories for collecting and testing samples with acute respiratory tract infections. Surveillance of emergency room visits and outpatient department visits for influenza-like illness (ILI) were conducted using the Real-Time Outbreak and Disease Surveillance system and the National Health Insurance program data, respectively. Hospitalized cases with severe complications and deaths were reported to the National Notifiable Disease Surveillance System. Results During the 2009–10 influenza season, pandemic A(H1N1) 2009 was the predominant circulating strain and caused 44 deaths. However, the 2010–11 influenza season began with A(H3N2) being the predominant circulating strain, changing to A(H1N1) 2009 in December 2010. Emergency room and outpatient department ILI surveillance displayed similar trends. By March 31, 2011, there were 1,751 cases of influenza with severe complications; 50.1% reported underlying diseases. Of the reported cases, 128 deaths were associated with influenza. Among these, 93 (72.6%) were influenza A(H1N1) 2009 and 30 (23.4%) A(H3N2). Compared to the pandemic period, during the immediate post-pandemic period, increased number of hospitalizations and deaths were observed, and the patients were consistently older. Conclusions Reemergence of influenza A(H1N1) 2009 during the 2010–11 influenza season had an intense activity with age distribution shift. To further mitigate the impact of future influenza epidemics, Taiwan must continue its multifaceted influenza surveillance systems, remain flexible with antiviral use policies, and revise the vaccine policies to include the population most at risk.