Miracle-dz/UniFAR-FTUs huggingface dataset:
Lost in Translation? Meaning and Decision Making in Actual and Possible Worlds

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A Phase I study of combined modality (90)Yttrium-CC49 intraperitoneal radioimmunotherapy for ovarian cancer.

PURPOSE The purpose of this study was to determine the feasibility and maximum tolerated dose of (90)Yttrium-CC49 ((90)Y-CC49) as the radioimmunotherapy (RIT) component of an i.p. combined modality treatment for recurrent ovarian cancer. EXPERIMENTAL DESIGN A Phase I trial of (90)Y-CC49 RIT was conducted in ovarian cancer patients who had persistent or recurrent intra-abdominal disease, had failed one or two prior chemotherapy regimens, and demonstrated TAG-72 expression. Patients were treated with a previously established combined modality treatment protocol of s.c. IFN alpha2b, i.p. paclitaxel, and increasing dosages of i.p. (90)Y-CC49. Patients were monitored for toxicity, generation of human antimouse antibody response, and clinical efficacy. RESULTS Twenty eligible patients were treated per study specifications. All patients had been treated with debulking and paclitaxel/carboplatin-based chemotherapy at initial diagnosis. The patients included 11 patients with persistent disease at the time of second look laparotomy and 9 patients with delayed recurrence. Patients were treated with i.p. (90)Y-CC49 given in combination with s.c. IFN alpha2b (dose of 3 x 10(6) units for a total of four doses) and i.p. paclitaxel (dose of 100 mg/m(2)). RIT treatment was associated with primarily hematological toxicity. The maximum tolerated dose of i.p. (90)Y-CC49 was established at 24.2 mCi/m(2) in this combined regimen. Of nine patients with measurable disease, two had partial responses lasting 2 and 4 months. Of 11 patients with nonmeasurable disease, median time to progression was 6 months in 7 patients who recurred; 4 of these patients remain no evidence of disease at 9+, 18+, 19+, and 23+ months. CONCLUSIONS (90)Yttrium-CC49-based RIT in combination with IFN alpha2b and i.p. paclitaxel is feasible and well tolerated at a dose of < or =24.2 mCi/m(2).
Hashmod: A Hashing Method for Scalable 3D Object Detection

We present a scalable method for detecting objects and estimating their 3D poses in RGB-D data. To this end, we rely on an efficient representation of object views and employ hashing techniques to match these views against the input frame in a scalable way. While a similar approach already exists for 2D detection, we show how to extend it to estimate the 3D pose of the detected objects. In particular, we explore different hashing strategies and identify the one which is more suitable to our problem. We show empirically that the complexity of our method is sublinear with the number of objects and we enable detection and pose estimation of many 3D objects with high accuracy while outperforming the state-of-the-art in terms of runtime.
Siphoning Hidden-Web Data through Keyword-Based Interfaces

In this paper, we proposed the first, fully-automatic approach to crawling the Hidden Web through keyword-based interfaces. Our crawler uses an algorithm for automatically deriving a series of keyword-based queries whose goal is to obtain high coverage while minimizing the costs. In other words, our goal is to retrieve as much of the hidden contents as possible while minimizing the number of required queries. The intuition behind our algorithm is that, by obtaining samples of the hidden contents in a online database or document collection, we are able to discover keywords that have high frequency. Then, by using these high-frequency keywords we are able to construct queries that return a large number of answers.
On the Optimisation of SiGe-Base Bipolar Transistors

Extensive computer simulations of NPN SiGe-base bipolar transistors were performed to examine the effect of the Ge profile in the electrical characteristics. It is shown that extra charge storage in the emitter-base (E-B) junction, caused by the Ge profile, affects the device performance considerably. In addition, it is shown that an abrupt Ge profile in the middle of the base region is optimal for a given critical layer thickness of approximately 600A.
Assessment of Implicit Meaning in the Design of Graphic Symbols for the Control of Recycled Water Use

This article describes the empirical development and validation of graphic symbols to be affixed to sources of recycled water. The symbols are intended to encourage the use of recycled water in ways that do not endanger the environment or public health. The current identification system does not provide specific information concerning levels of quality (pollution levels) of recycled water, nor does it provide positive comparative information. In the design and validation of more effective symbols, cognitive elicitation techniques were used to assess the normative implicit meaning of stimulus values of hue and brightness with respect to five levels of water quality. Although both hue and brightness choices were systematically related to water qualities, the implicit meaning of brightness values was clearer. A validity assessment of the untrained meanings of symbols based on brightness and supplemented by hue supported both their implicit comprehensibility and the empirical strategy employed in their design.
Analysis of Security Requirements, Attacks and Vulnerabilities at Transport Layer in Wireless Sensor Networks

For about last two decades research and development processes in area of Electronics and Sensors have resulted as significant advancements in electronics and technology, small size, cost effectiveness have resulted sensor nodes as crucial part of real world problem solution applications. The wireless sensor nodes are spread over an area to record the facts of situations like fire, flood and then forward same to meaningful data to the a node, which is generally cluster head node for calculations, resulting an alert to take necessary measures to control the situation. In last few years, WSN have increased significantly in variety of areas and applications, resulted the contemporary demand of high, consistent security mechanism. Also, there is variety of attacks on WSN at their different layers. These tiny, low processing sensor nodes are not strong enough in terms of power, handling attack issues etc. On other hand, applications based on these sensors demand on-time streamed data or information is to be collected and then to send same on a reliable, secure delivery mechanism. Tiny sensors with limited hardware, processing are not able to afford old and in practice security protocols or algorithms to face or sustain the attacks. Many attacks impact WSNs. at their different layers an affect sensor’s roles like signaling, framing, transmission etc. Many attacks have been identified at each layer of WSN which are intended, pre-planned attacks to obstacle the availability of service, restricting the sensor node’s utilization in solution of a for problem. This paper is mainly focused on WSN structure, threats, attacks and security requirements and security measures against attacks; especially various types of attacks starting from physical layer and data link, network layers, subsequently and particularly variety of attacks at transport layer in details with some effective suggestions as prevention or protection against those attacks.
Prospecting for Unannotated Enzymes: Discovery of a 3′,5′-Nucleotide Bisphosphate Phosphatase within the Amidohydrolase Superfamily

In bacteria, 3′,5′-adenosine bisphosphate (pAp) is generated from 3′-phosphoadenosine 5′-phosphosulfate in the sulfate assimilation pathway, and from coenzyme A by the transfer of the phosphopantetheine group to the acyl-carrier protein. pAp is subsequently hydrolyzed to 5′-AMP and orthophosphate, and this reaction has been shown to be important for superoxide stress tolerance. Herein, we report the discovery of the first instance of an enzyme from the amidohydrolase superfamily that is capable of hydrolyzing pAp. Crystal structures of Cv1693 from Chromobacterium violaceum have been determined to a resolution of 1.9 Å with AMP and orthophosphate bound in the active site. The enzyme has a trinuclear metal center in the active site with three Mn2+ ions. This enzyme (Cv1693) belongs to the Cluster of Orthologous Groups cog0613 from the polymerase and histidinol phosphatase family of enzymes. The values of kcat and kcat/Km for the hydrolysis of pAp are 22 s–1 and 1.4 × 106 M–1 s–1, respectively. The enzyme is promiscuous and is able to hydrolyze other 3′,5′-bisphosphonucleotides (pGp, pCp, pUp, and pIp) and 2′-deoxynucleotides with comparable catalytic efficiency. The enzyme is capable of hydrolyzing short oligonucleotides (pdA)5, albeit at rates much lower than that of pAp. Enzymes from two other enzyme families have previously been found to hydrolyze pAp at physiologically significant rates. These enzymes include CysQ from Escherichia coli (cog1218) and YtqI/NrnA from Bacillus subtilis (cog0618). Identification of the functional homologues to the experimentally verified pAp phosphatases from cog0613, cog1218, and cog0618 suggests that there is relatively little overlap of enzymes with this function in sequenced bacterial genomes.
The emperor and research on women in school leadership: A response to Julie Laible?s loving epistemology

Reflecting on the epistemologies framing research on women school leaders, this article shows how the hegemonic controls of the question-framing now is laid bare. The question-framing once focused on individual women, as unique and strange, then evolved to recognize their institutional context, and the barriers. But, without the activist and values stance for research, the embedded institutional power could control such research and policy implications were weak. However, researchers now expose exclusionary power moves and devise research that incorporates women? s truths.
Measurement Scheme Improving for State Estimation Using Stochastic Tabu Search

This paper proposes the stochastic tabu search (STS) for improving the measurement scheme for power system state estimation. If the original measured scheme is not observable, the additional measurements with minimum number of measurements are added into the system by STS so that there is no critical measurement pair. The random bit flipping and bit exchanging perturbations are used for generating the neighborhood solutions in STS. The Pδ observable concept is used to determine the network observability. Test results of 10 bus, IEEE 14 and 30 bus systems are shown that STS can improve the original measured scheme to be observable without critical measurement pair. Moreover, the results of STS are superior to deterministic tabu search (DTS) in terms of the best solution hit. Keywords—Measurement Scheme, Power System State Estimation, Network Observability, Stochastic Tabu Search (STS).
Prenatal Tobacco, Marijuana, Stimulant, and Opiate Exposure: Outcomes and Practice Implications

Abuse of drugs by pregnant women both in the United States and worldwide has raised many questions regarding the effects of prenatal drug exposure on the developing fetus and subsequent child outcomes. Studies using the neurobehavioral teratology model have been undertaken to determine specific prenatal drug effects on cognitive and behavioral development. Here we summarize the findings of studies that have investigated the developmental effects of prenatal exposure to tobacco, marijuana, stimulants, and opiates. These studies consider the timing and amount of prenatal exposure; other drug exposures; maternal characteristics; and other health, nutritional, and environmental factors. We review treatment options for pregnant, substance-dependent women and therapeutic interventions for exposed children.
Brownian Motion on a Smash Line

Abstract Brownian motion on a smash line algebra (a smash or braided version of the algebra resulting by tensoring the real line and the generalized paragrassmann line algebras), is constructed by means of its Hopf algebraic structure. Further, statistical moments, non stationary generalizations and its diffusion limit are also studied. The ensuing diffusion equation possesses triangular matrix realizations.
The Effect of IT Capabilities on Crossfunctional Capabilities

Research in both the strategy and information systems (IS) areas has identified capabilities as key to competing effectively in dynamic and turbulent environments. Firms realize benefits by adopting complementary combinations of capabilities. We draw on Grant’s hierarchy of capabilities to develop a model that explains how a firm’s information technology (IT) capabilities can enhance the intangible value of the firm through their effect on a set of cross-functional capabilities. Using a sample of 394 firms drawn from industry ranking surveys, our preliminary results suggest that some cross-functional capabilities have a positive impact on the long term, intangible performance of a firm as measured by Tobin’s q.
Presence of Endothelium in an Axillary‐femoral Graft of Knitted Dacron With an External Velour Surface

An axillary-bilateral common femoral graft of knitted Dacron with an external velour surface was examined within one hour after the patient's death from non-graft-related causes. The prothesis, implanted for 20 months, was patent and was completely healed over 32% of the flow surface—that is, full wall fibrous tissue encapsulation of the graft had occurred, and 32% of the flow surface was endothelialized. The remaining flow surface was formed of fibrin, but fibrous tissue healing had reached the inner surface of the graft material, and the fibrin overlay was very thin. The healed portions of the graft included not only the areas adjacent to the anastomoses, but were scattered throughout the 45 cm length of the prosthesis. To our knowledge, this is the first report of complete healing (fibrous tissue encapsulation and endothelialization) documented at points beyond the pannus ingrowth at the prosthesis-artery anastomosis.
Magnesium Excretion in C. elegans Requires the Activity of the GTL-2 TRPM Channel

Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. elegans excretory cell to mediate the excretion of excess magnesium. Thus, the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1.
Teachers' Controversial Issue Decisions Related to Race, Gender, and Religion During the 2008 Presidential Election

Using the 2008 Presidential Election as a case of curricular controversy, the author describes how six high school government teachers responded to the racial, gender, and religious diversity included on the presidential tickets of the two major political parties. Teachers had to decide whether the issue of Americans challenging the tradition of electing White males to the federal executive branch would be deemed “open” or “closed” in their classes, and if they were deemed open, whether they would disclose their own opinions on the issue. The findings suggest that Obama's race was a closed issue in each of the classes in terms of his eligibility for the presidency; however, the teachers and their students implicitly recognized the openness of the issue within both a broader societal context as well as their own political decision-making. Similarly, Palin's gender was also a closed issue in terms of her eligibility for the vice presidency, but the sexist comments made by students and teachers at each school suggest that although they may not have found Palin's candidacy controversial, her gender was an open issue with respect to how they judged female politicians in comparison to their male counterparts. Finally, Obama's religious background was a largely closed issue, although individual teachers positioned it as an open issue in their classes and used it to justify their belief that non-Christians should not be elected president. These findings offer implications for the teaching of controversial issues that are contextualized within traditionally taboo topics of race, gender, and religion.
Evaluation of the performance of the novel PapilloCheck® HPV genotyping test by comparison with two other genotyping systems and the HC2 test

The novel PapilloCheck® genotyping test was compared with SPF10 PCR LiPav1 and PGMY09/11 on hybrid capture 2 (HC2)‐pretested samples. From results of 826 cervical samples detection rates and kappa values for the tests were calculated using a HPV type consensus definition. With PapilloCheck® HPV types 53, 56, and 33 were found with a sensitivity of 100%. The lowest detection rate was observed for HPV 35 (72.2%). The SPF10 PCR LiPav1 was found to be 100% positive for HPV 18, 31, 53, 56, and 35 and lowest for HPV 59 (81%). The PGMY09/11 system detected only HPV 59 at 100% detection rate and showed lowest sensitivity for HPV 56 (40.5%). Multiple infection rates ranged from 25.8% (PGMY09/11 PCR‐LBA), over 39.5% (PapilloCheck®) to 55.9% (SPF10 PCR LiPav1). In samples with higher viral DNA load detection rates and concordance between the genotyping tests increases. The kappa values in comparison to the HPV consensus type ranged from k = 0.21 to k = 0.82 for comparing SPF10 PCR with the HPV consensus type, while values for PGMY09/11 PCR ranged from k = 0 to k = 0.96 and were best for the PapilloCheck® (k = 0.49–0.98). Detection rates for the identification of high‐grade cervical intraepithelial neoplasia (CIN2+) ranged from 93.7% (PGMY09/11 PCR) to 98.4% (PapilloCheck®, SPF10 PCR, HC2). In conclusion, this study shows that the PapilloCheck® give comparable results to established PCR methods. However, these results also show a necessity for the standardization of genotype‐specific HPV detection assays. J. Med. Virol. 82:605–615, 2010. © 2010 Wiley‐Liss, Inc.
Typologies of Compulsive Buying Behavior: A Constrained Clusterwise Regression Approach

We present a theoretical framework that posits compulsive buying behavior as a function of various psychological processes and personality traits. We analyze data from actual consumers using a new constrained maximum likelihood clusterwise regression procedure to examine the nature of consumer heterogeneity in compulsive buying behavior. This empirical analysis distinguishes between 2 clusters, or groups, of compulsive buyers in terms of differential drivers of their compulsive buying. A posterior regression analysis reveals additional differences in background characteristics for each cluster. A discussion of future research issues and other applications is provided.
Comparison of the detectability and annoyance value of embedded MPEG-2 artifacts of different type, size, and duration

One fundamental problem in predicating the subject5ive quality of a degraded video is that the perceived quality depends on the properties of the video itself, or the context of the degradation. In this paper, we present the result for a series of experiments designed to measure the detection thresholds and annoyance values of small regions of MPEG-2 artifacts inserted into mostly uncorrupted video sequences. In previous work, we found that the detection threshold contains much, but not all, of the information needed to remove the dependence of quality on the context. In this paper, we report the result of two experiments. In one experiment, we varied the type of MPEG-2 artifacts inserted into the test sequences. In the other experiment, we varied the location , size, and duration of the corrupted regions in the test sequences. From each set of dat, we estimated detection thresholds and fitted the parameters of a quality function. The experimental results demonstrated that, under a wide set of test conditions, the detection threshold is still very useful for the estimation of quality as context varies. In fact, the detection threshold was the only factor necessary to model the changes in the quality function parameters with artifact type. The experimental data showed that the detection threshold and the quality function parameters do depend on the size and duration of the degraded region. However, the effects of size and duration are minor relative to the effect of artifact location.
New Adaptive Mode of Operation for MEMS Gyroscopes

This paper presents a new adaptive operation strategy that can identify and, in an adaptive fashion, compensate for most fabrication defects and perturbations affecting the behavior of a MEMS z-axis gyroscope. The convergence and resolution analysis presented in the paper shows that the proposed adaptive controlled scheme offers several advantages over conventional modes of operation. These advantages include a larger operational bandwidth, absence of zero-rate output, self-calibration and a large robustness to parameter variations, which are caused by fabrication defects and ambient conditions.
Reverse Phase Ultrafast Liquid Chromatography Method for Simultaneous Estimation of Citicoline Sodium and Piracetam in Tablets

A simple, precise and accurate RP-UFLC method was developed for simultaneous determination of citicoline sodium and piracetam in tablets. Separation was carried on an Enable C18G column (250 mm × 4.6 mm i.d., 5 μm) using methanol: water (10 mM TEA) (75:25, v/v) as mobile phase at flow rate of 1 ml/min in isocratic mode. The PDA detection wavelength was 225 nm. The retention time of citicoline sodium and piracetam were 1.985 and 3.007 min, respectively. The method was validated for linearity, specificity, precision, accuracy and robustness as per ICH guidelines. The method was linear in the concentration range of 1.0 –250 μg/ml with correlation coefficients of 0.999 for both the drugs. The LOD and LOQ for citicoline sodium were 0.25 μg/ml and 0.81 μg/ml, respectively, and for piracetam 0.28 μg/ml and 0.93 μg/ml, respectively. The average recoveries for recovery study were found to be in the range of 100.24-101.09% and 100.08-101.05% for citicoline sodium and piracetam, respectively. The R.S. D. values for intraday, interday and system precision were found to be less than 2%. The method was applied successfully for simultaneous estimation of citicoline sodium and piracetam in combined tablet formulation.