Miracle-dz/UniFAR-FTUs huggingface dataset:
Men's Desire for Children Carrying Their Genes and Sexual Jealousy: A Test of Paternity Uncertainty as an Explanation of Male Sexual Jealousy

In a classic study, Buss, Larson, Westen, and Semmelroth found that men were more distressed by the thought of a partner's sexual infidelity (labeled sexual jealousy) and women were more distressed by the thought of a partner's emotional infidelity (labeled emotional jealousy). Buss and his associates explained the results by suggesting that men are concerned about uncertainty of paternity, that is, the possibility of raising another man's child while believing that the child is their own. To test this explanation, the Desire for Children Scale was created. Its internal consistency and test-retest reliabilities were . 86 and . 89, respectively. Scores correlate with stated Number of Children Desired (convergent validity) but none of the Big-Five traits (divergent validity). It was hypothesized that for men scores on this scale would correlate positively with scores on sexual jealousy. The Desire for Children Scale and the two Sexual vs Emotional Jealousy items of Buss and his associates were given to 49 men and 55 women college students enrolled in psychology courses. Their average age was 19.9 yr. (SD = 3.7), and average year in school was 2.0 (SD= 1.2). Subjects volunteered to participate in the study in exchange for course credit. The hypothesis was confirmed and gives support to the uncertainty of paternity explanation.
Podosome dynamics and location in vascular smooth muscle cells require CLASP‐dependent microtubule bending

Extracellular matrix (ECM) remodeling during physiological processes is mediated by invasive protrusions called podosomes. Positioning and dynamics of podosomes define the extent of ECM degradation. Microtubules are known to be involved in podosome regulation, but the role of microtubule (MT) network configuration in podosome dynamics and positioning is not well understood. Here, we show that the arrangement of the microtubule network defines the pattern of podosome formation and relocation in vascular smooth muscle cells (VSMCs). We show that microtubule plus‐end targeting facilitates de novo formation of podosomes, in addition to podosome remodeling. Moreover, specialized bent microtubules with plus ends reversed towards the cell center promote relocation of podosomes from the cell edge to the cell center, resulting in an evenly distributed podosome pattern. Microtubule bending is induced downstream of protein kinase C (PKC) activation and requires microtubule‐stabilizing proteins known as cytoplasmic linker associated proteins (CLASPs) and retrograde actin flow. Similar to microtubule depolymerization, CLASP depletion by siRNA blocks microtubule bending and eliminates centripetal relocation of podosomes. Podosome relocation also coincides with translocation of podosome‐stimulating kinesin KIF1C, which is known to move preferentially along CLASP‐associated microtubules. These findings indicate that CLASP‐dependent microtubule network configuration is critical to the cellular location and distribution of KIF1C‐dependent podosomes. © 2016 Wiley Periodicals, Inc.
Dealing with Complex Patterns in XML Processing

The handling of search patterns for data access is critical to XML processing. Most efforts to integrate XML processing into general-purpose programming languages add different features to existing languages for different kinds of patterns, or even create completely new languages. The resulting languages only work for certain kinds of patterns and are hard to extend to others in a well typed manner. This poses burdens for both language designers and programmers, and restricts XML applications. In this paper we present an alternative approach that handles many kinds of patterns within the same framework. The key idea is to express complex patterns by pattern structures in one general-purpose programming language based on the pattern calculus. With this approach, adding a new kind of patterns is just a matter of programming, not language design; programs can be highly parametric over well-typed complex patterns. Dealing with Complex Patterns in XML Processing F.Y. Huang and C.B. Jay and D.B. Skillicorn Abstract: The handling of search patterns for data access is critical to XML processing. Most efforts The handling of search patterns for data access is critical to XML processing. Most efforts to integrate XML processing into general-purpose programming languages add different features to existing languages for different kinds of patterns, or even create completely new languages. The resulting languages only work for certain kinds of patterns and are hard to extend to others in a well typed manner. This poses burdens for both language designers and programmers, and restricts XML applications. In this paper we present an alternative approach that handles many kinds of patterns within the same framework. The key idea is to express complex patterns by pattern structures in one general-purpose programming language based on the pattern calculus. With this approach, adding a new kind of patterns is just a matter of programming, not language design; programs can be highly parametric over well-typed
Grade Inflation and Labour Market Matching a

A model is presented where workers of differing abilities and from different social backgrounds are assigned to jobs based on grades received at school. It is examined how this matching is affected if good grades are granted to some low ability students. Such grade inflation is shown to reduce the aggregate wage of the lower class workers because employers use social origin as a signal for productivity if grades are less than fully informative. Moreover, the high-ability students from the higher class may benefit from grade inflation since this shields them from the competition on the part of able students from the lower classes.
Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells

MUC16 (CA125) is a type-I transmembrane glycoprotein that is up-regulated in multiple cancers including pancreatic cancer (PC). However, the existence and role of carboxyl-terminal MUC16 generated following its cleavage in PC is unknown. Our previous study using a systematic dual-epitope tagged domain deletion approach of carboxyl-terminal MUC16 has demonstrated the generation of a 17-kDa cleaved MUC16 (MUC16-Cter). Here, we demonstrate the functional significance of MUC16-Cter in PC using the dual-epitope tagged version (N-terminal FLAG- and C-terminal HA-tag) of 114 carboxyl-terminal residues of MUC16 (F114HA). In vitro analyses using F114HA transfected MiaPaCa-2 and T3M4 cells showed enhanced proliferation, motility and increased accumulation of cells in the G2/M phase with apoptosis resistance, a feature associated with cancer stem cells (CSCs). This was supported by enrichment of ALDH+ CSCs along with enhanced drug-resistance. Mechanistically, we demonstrate a novel function of MUC16-Cter that promotes nuclear translocation of JAK2 resulting in phosphorylation of Histone-3 up-regulating stemness-specific genes LMO2 and NANOG. Jak2 dependence was demonstrated using Jak2+/+ and Jak2−/− cells. Using eGFP-Luciferase labeled cells, we demonstrate enhanced tumorigenic and metastatic potential of MUC16-Cter in vivo. Taken together, we demonstrate that MUC16-Cter mediated enrichment of CSCs is partly responsible for tumorigenic, metastatic and drug-resistant properties of PC cells.
Non-negative Matrix Factorization Using Bregman Monotone Operator Splitting

A non-negative matrix factorization (NMF) algorithm based on Bregman monotone operator splitting (B-MOS) is proposed. Several commonly used NMF algorithms, such as the multiplicative update method, are often used in source separation for speech and image signals. To improve the convergence rate in the tail, applying the alternating direction method of multipliers (ADMM) is reported to be effective. However, a fixed step-size parameter has to be carefully chosen for fast and stable convergence. Our main idea to overcome this issue is to adaptively modify the variable space metric so that it matches the cost convexity. Besides this, selecting an appropriate MOS (e.g., Peaceman-Rachford splitting) instead of the Douglas-Rachford splitting used in the ADMM may effectively improve the convergence rate further. To realize these ideas w.r. t. adaptive metric modification and appropriate operator splitting selection, we apply B-MOS to the NMF problem and obtain a new NMF solver in this paper. Results of numerical experiments demonstrate that the proposed NMF solver with B-MOS improved the convergence rate in the tail.
Human immunodeficiency virus fitness in vivo: calculations based on a single zidovudine resistance mutation at codon 215 of reverse transcriptase

We monitored a subject newly infected with a zidovudine-resistant human immunodeficiency virus type 1 strain and found that in the absence of drug, the viral population with the resistance-conferring tyrosine (TAC) codon 215 of reverse transcriptase was gradually replaced. By using standard formulas to model the effects of selection at a single locus in an asexual haploid population, the relative fitness gain of the viral population with a single mutation at codon 215 creating a serine (TCC) was calculated. We concluded that a viral population with a serine at reverse transcriptase codon 215 conferring zidovudine sensitivity was between 0.4 and 2.3% more fit.
Electrical powered tail rotor of a helicopter

본 발명은 테일로터(1) 주위의 하우징(2), 및 극(9)의 개수가 증가된 스테이터(6, 7)를 구비한 적어도 하나의 영구자석 작동 동기모터를 포함하는 헬리콥터의 전동 테일로터(1)에 관한 것이다. 상기 적어도 하나의 동기모터는 테일로터(1)를 둘러싸는 하우징(2)의 개구 주위에 원환체로서 통합된다. 테일로터(1)의 블레이드(4)는 상기 적어도 하나의 동기모터의 적어도 하나의 회전 구성요소(10, 11)에 고정된다. 공급 수단은 상기 적어도 하나의 동기모터에 전기 에너지를 제공한다. 원환체(8)에는 블레이드 피치 제어 수단이 마련된다.
Binding Properties of the C‐terminal Domain of VIAF

The protein X‐linked inhibitor of apoptosis (XIAP) plays an important role in caspase inactivation and as a consequence in the inhibition of apoptosis. It is known that IAP antagonists are able to specifically bind XIAP and reactivate caspase activity stimulating apoptosis. The viral IAP‐associated factor (VIAF) protein is a novel IAP‐interacting factor able to modulate caspase activation during apoptosis. We show that the C‐terminal domain of VIAF (c‐VIAF) is not able in vitro to behave as a direct IAP antagonist. By [15N–1H] HSQC NMR studies we revealed that c‐VIAF binds to the RING domain of XIAP and characterized the important residues involved in the binding. Through 1D 1H‐NMR screening of 1000 compounds from an in‐house collection, we found that compound BI‐86‐E10 is able to bind to c‐VIAF in a region adjacent to that interacting with the RING domain of XIAP, as supported by homology modeling and computational docking studies. After an initial round of SAR, the compound analog BI‐86‐E6 was found to bind with a Kd value of 16.5 μm. These initial compounds may serve as chemical probes for further functional studies, possibly aimed at validating c‐VIAF as a novel target for antiviral drug development.
Natural history of cognitive decline in the old old

Objective: To prospectively examine the occurrence and outcome of cognitive decline in healthy, community-dwelling elders. Methods: Ninety-five elders (mean age 84 years) who at entry had no cognitive impairment were followed for up to 13 years. Cognitive decline was defined as obtaining either a Clinical Dementia Rating (CDR) = 0.5 or Mini-Mental State Examination (MMSE) score < 24 on two examinations. Results: Three outcomes of aging were determined: intact cognition, persistent cognitive decline without progression to dementia, and dementia. Whereas 49% remained cognitively intact, 51% developed cognitive decline. Mean follow-up to first CDR 0.5 was 3.8 years and age at conversion was 90.0 years. Those who remained cognitively intact had better memory at entry and were less likely to have APOE4 than those who developed cognitive decline. Of the 48 participants with cognitive decline, 27 (56%) developed dementia (CDR ≥1) a mean of 2.8 years later. Participants with cognitive decline who progressed to dementia had poorer confrontation naming at the time of their first CDR 0.5 than those with persistent cognitive decline who did not progress during follow-up. Conclusion: The old old are at high risk for developing cognitive decline but many will not progress to dementia in the next 2 to 3 years or even beyond. These findings are important for understanding the prognosis of cognitive decline and for the design of treatment trials for AD. APOE genotype is a risk factor for cognitive decline.
NONLINEAR ADAPTIVE IMAGE PROCESSING IN TRANSFORM DOMAIN

A family of local adaptive filters for image restoration and enhancement is described. The filters work in a moving window in the domain of an orbhogonal transform and, in each position of the window, produce an estimation of the central pixel of the window by nonlinear transformations of the window spectra1 coefficients. The filter synthesis on the base of local mean squared error restoration criterion is outlined, the use of Discrete Fourier and Discrete Cosine Transforms as orthogonal transforms is justified and recursive algorithm of multicomponent local DCT spectra1 analysis is described. Performance of filtering is illustrated by examples of edge preserving noise suppression and blind restoration of color images
Collision-free visual servoing of an eye-in-hand manipulator via constraint-aware planning and control

A constraint-aware eye-in-hand visual servoing control law is proposed. The control law is designed for a robot manipulator with an uncalibrated camera mounted on its end-effector. The method uses an image-based command to describe the desired end-effector position with respect to an object with an unknown position. When starting from an unknown position, the control law uses feedback from the camera to move the robot towards the reference image while satisfying a set of system constraints. The visual servoing control law is implemented via a nonlinear model predictive control framework to generate feasible and realistic robot trajectories that respect the robot's joint limits and velocity limits. The control law explicitly keeps the target object within the camera's field of view and avoids potential collisions with workspace obstacles. An appropriate representation of the robot's whole-arm collision constraints is extracted from well-known path planning methods, such as probabilistic road maps and dynamic collision checking algorithms. Experiments using an uncalibrated eye in-hand platform demonstrate the ability of the visual servoing control law to achieve closed-loop positioning via collision-free trajectories, even when the initial object location is uncertain.
Atmospheric Chemistry and Physics Global Multi-year O 3 -co Correlation Patterns from Models and Tes Satellite Observations

The correlation between measured tropospheric ozone (O 3) and carbon monoxide (CO) has been used extensively in tropospheric chemistry studies to explore the photochemical characteristics of different regions and to evaluate the ability of models to capture these characteristics. Here, we present the first study that uses multi-year, global, vertically resolved, simultaneous and collocated O 3 and CO satellite (Tropospheric Emission Spectrometer) measurements , to determine this correlation in the middle/lower free troposphere for two different seasons, and to evaluate two chemistry-climate models. We find results that are fairly robust across different years, altitudes and timescales considered , which indicates that the correlation maps presented here could be used in future model evaluations. The highest positive correlations (around 0.8) are found in the northern Pacific during summer, which is a common feature in the observations and the G-PUCCINI model. We make quantitative comparisons between the models using a single-figure metric (C), which we define as the correlation coefficient between the modeled and the observed O 3-CO correlations for different regions of the globe. On a global scale, the G-PUCCINI model shows a good performance in the summer (C = 0.71) and a satisfactory performance in the winter (C = 0.52). It captures midlatitude features very well, especially in the summer, whereas the performance in regions like South America or Central Africa is weaker. The UKCA model (C = 0.46/0.15 for July–August/December–January on a global scale) performs better in certain regions, such as the tropics in winter, and it captures some of the broad characteristics of summer extratropical correlations, but it systematically underestimates the O 3-CO correlations over much of the globe. It is noteworthy that the correlations look very different in the two models, even though the ozone distributions are similar. This demonstrates that this technique provides a powerful global constraint for understanding mod-eled tropospheric chemical processes. We investigated the sources of the correlations by performing a series of sensitivity experiments. In these, the sign of the correlation is, in most cases, insensitive to removing different individual emissions, but its magnitude changes downwind of emission regions when applying such perturbations. Interestingly, we find that the O 3-CO correlation does not solely reflect the strength of O 3 photochemical production, as often assumed by earlier studies, but is more complicated and may reflect a mixture of different processes such as transport.
A model for navigating interview processes in requirements elicitation

Experts in requirements elicitation interview stakeholders using various levels of knowledge to grasp and elicit users' requirements. This paper analyzes expert interview processes and explores a computation model for simulating them. This model can be used to navigate a novice analyst's interview processes. It consists of a blackboard model and a state transition model in order to narrow the candidates for questions that an expert analyst will ask stakeholders next in the interview process. The candidates are selected based on information that has been elicited from stakeholders, and the blackboard model is for holding this information in the form of IEEE 830, a standard form of requirements specification documents. We have analyzed experts' interview processes and constructed a computation model in the sales management domain. We also recorded novice processes and showed that we could improve them by means of the model.
A novel method for capsule endoscopy video automatic segmentation

Wireless capsule endoscopy (WCE) is a recently developed revolutionary medical technology which records the video of human's digestive tract noninvasively. However, reviewing a WCE video is a tired and time-consuming task for clinicians. Thus, WCE video automatic segmentation methods are emerging to reduce the review time for clinicians. In our previous work, a two-level WCE video segmentation approach has been proposed, which provides a novel approach to localize the boundaries more exactly and efficiently. However, it has an unsatisfactory performance in the small intestine/large intestine boundary detection. In this paper, we propose new features and an improved classifier to improve the previous two-level segmentation algorithm. In the rough level, color feature is utilized to draw a dissimilarity curve and an approximate boundary has been obtained. At the same time, training data for fine level can be directly labeled and collected between the two approximate boundaries of organs to overcome the difficulty of training data acquisition. In the fine level, a novel color uniform local binary pattern (CULBP) algorithm is proposed, which includes two kinds of patterns, color norm patterns and color angle patterns. The CULBP feature is more robust to variation of illumination and more discriminative for classification. Moreover, in order to elevate the performance of SVM classifier we proposed the Ada-SVM classifier which using RBFSVMs as component of Adaboost classifier. At last, an analysis of classification results of the Ada-SVM classifier is carried out to segment the WCE video into several meaningful parts, stomach, small intestine and large intestine. The experiments demonstrate a promising performance of the proposed method. The average precision and recall are as high as 91.37% and 88.50% in stomach/small intestine classification, 90.35% and 97.28% in small intestine/ large intestine classification.
A research on flexible enterprise WLAN system based web of place access points

Open Source Hardware is widely used as enterprise standard device because it has high performance for its price. Traditional enterprise Wireless Local Area Network has the limitation of functionality and scalability by the deployed network equipment. To solve this problem, we propose `Web of Place Access Point' using raspberry pi that enable to manage the scale of the network and to provide enterprise suitable network function.
Two-Photon Compatibility and Single-Voxel, Single-Trial Detection of Subthreshold Neuronal Activity by a Two-Component Optical Voltage Sensor

Minimally invasive measurements of neuronal activity are essential for understanding how signal processing is performed by neuronal networks. While optical strategies for making such measurements hold great promise, optical sensors generally lack the speed and sensitivity necessary to record neuronal activity on a single-trial, single-neuron basis. Here we present additional biophysical characterization and practical improvements of a two-component optical voltage sensor (2cVoS), comprised of the neuronal tracer dye, DiO, and dipicrylamine (DiO/DPA). Using laser spot illumination we demonstrate that membrane potential-dependent fluorescence changes can be obtained in a wide variety of cell types within brain slices. We show a correlation between membrane labeling and the sensitivity of the magnitude of fluorescence signal, such that neurons with the brightest membrane labeling yield the largest ΔF/F values per action potential (AP; ∼40%). By substituting a blue-shifted donor for DiO we confirm that DiO/DPA works, at least in part, via a Förster resonance energy transfer (FRET) mechanism. We also describe a straightforward iontophoretic method for labeling multiple neurons with DiO and show that DiO/DPA is compatible with two-photon (2P) imaging. Finally, exploiting the high sensitivity of DiO/DPA, we demonstrate AP-induced fluorescence transients (fAPs) recorded from single spines of hippocampal pyramidal neurons and single-trial measurements of subthreshold synaptic inputs to granule cell dendrites. Our findings suggest that the 2cVoS, DiO/DPA, enables optical measurements of trial-to-trial voltage fluctuations with very high spatial and temporal resolution, properties well suited for monitoring electrical signals from multiple neurons within intact neuronal networks.
Ensuring Efficient and Robust Offshore Storage – The Role of Marine System Modelling

This paper describes the utility of developing marine system models to aid the efficient and regulatory compliant development of offshore carbon storage, maximising containment assurance by well-planned monitoring strategies. Using examples from several model systems, we show that marine models allow us to characterize the chemical perturbations arising from hypothetical release scenarios whilst concurrently quantifying the natural variability of the system with respect to the same chemical signatures. Consequently models can identify a range of potential leakage anomaly detection criteria, identifying the most sensitive discriminators applicable to a given site or season. Further, using models as in-silico testbeds we can devise the most cost-efficient deployment of sensors to maximise detection of CO2 leakage. Modelling studies can also contribute to the required risk assessments, by quantifying potential impact from hypothetical release scenarios. Finally, given this demonstrable potential we discuss the challenges to ensuring model systems are available, fit for purpose and transferable to CCS operations across the globe.