Miracle-dz/UniFAR-FTUs huggingface dataset:
Design of infrared electronic-toll-collection systems with LEDs with irregular radiation pattern

Infrared light emitting diods (LEDs) with a half-intensity angle Ф1/2 ≈ 10° are suitable for electronic-toll-collection (ETC) applications due to the requirement of a definite communication area between the on-board unit (OBU) and the road side unit (RSU). However, the radiation pattern of most low-cost commercial infrared LEDs are irregular to some extent leading to the difficulty to construct an infrared ETC system with a proper communication area. According to our measurements, most low-cost infrared LEDs with a half-intensity angle Ф1/2 ≈ 10° have a common irregularity in their radiation pattern — a notch in the central direction. The unwanted influence of such irregularities can be reduced by a proper array of the constituent LEDs in the emitter. To analyze the system performance, the irregularity can be approximated by a linear combination of cosinn functions. In this paper, we present some successful designs with the aid of an optimization algorithm to adjust the mounting angle of each component LED. In spite of the aforementioned irregularity, with our design the system can still have good performance in terms of the ability to withstand high signal attenuation and an extended communication area in the vehicle-traveling direction.
Bacteria Growth Monitoring Through a Differential CMOS Capacitive Sensor

In this paper, we present a bacteria growth monitoring technique using a complementary metal-oxide semiconductor capacitive sensor. The proposed platform features a differential capacitive readout architecture with two interdigitized reference and sensing electrodes. These electrodes are exposed to pure Luria-Bertani (LB) medium and Escherichia Coli (E. Coli) bacteria suspended in the LB medium, respectively. In order to direct the solutions toward the electrodes, two microfluidic channels are implemented atop the electrodes through a direct-write assembly technique. We thereafter demonstrate and discuss the experimental results by using two different bacteria concentrations in the order of 106 and 107 per 1 mL in the LB medium.
Empirical Evidence on the Relationship between Foreign Direct Investment and Economic Growth: A Cross-Country Exploration in Asia

The issue of capital flows is considered to be the most accessible route for economic growth whereby investment is regarded as the engine of growth. The worldwide changes have recognized the importance of Foreign Direct Investment (FDI) as one of the possible options to stimulate growth momentum. Against this backdrop this paper examines the short run and long run dynamics between economic growth and foreign direct investment for selected Asian economies covering the period from 1975 to 2010. A neo-classical production function is estimated to capture the short run dynamics followed by cointegration technique to capture the long run effect. This paper provides strong evidence regarding the existence of long run equilibrium relationship between FDI and growth for majority of the countries followed by varied causality between foreign direct investment and economic growth. The policy recommendations may not be uniform for the entire Asian region due to their diversified industrialization experience.
Survivor Benefits and the Gender-Related Tax Differential in Public Pension Schemes: Observations from Germany

Summary As a result of fundamental changes in marriage behaviour and the typical division of labour between married spouses, the traditional form of providing survivor benefits within public pension schemes could now be seen as inequitable. Since these non-contributory benefits usually substitute for individual pension entitlements based on the surviving spouse’s own contributions, they can also lead to incentive effects that appear to be far from optimal. In particular, they may weaken work incentives for married women with some degree of labour-force attachment. The present paper highlights this problem referring to institutional details and empirical results related to Germany and shows how it could be resolved by jointly annuitizing a given couple’s pension entitlements. Problems of transition, with the potential for a Pareto-improvement, are neglected.
The Modelling of the Volatility of Business cycles in Romania

The latest research highlights the existence of the asymmetry of the volatility of business cycles. In this context, in this paper we firstly aim to test whether the volatility of business cycles in Romania is constant or not and then, according to the identified result we try to model it. For the determination of business cycles of Romania we use the index of the industrial production registered during the period January 2000 – May 2011. The estimation of the business cycles is conducted by means of the Hodrick-Prescot filter. The results obtained confirm that the volatility of business cycles of Romania is not constant and suggest the possibility of taking into account the heteroscedastic models. The estimation of the EGARCH model shows that Romania’s business cycles present an asymmetric volatility.
Diverse management practices— a study of clinical managers

This article examines whether changes in the governance of public hospitals in Norway have affected the perceived practices of operational managers. A study involving a survey of and interviews with clinical managers in Norwegian hospitals has shown that managers considering themselves highly involved in management control practices. The managers' perception of their control activities was related to such institutional pressures as budget deficits, as well as to contextual variables such as department size. This article shows that clinical managers also use accounting information for purposes other than simply being accountable for meeting budgets.
Nucleotide sequence of the gene encoding the monocyte differentiation antigen, CD14.

We report here the nucleotide sequence of the gene encoding the monocyte cell surface differentiation antigen CD14. CD14 is expressed by monocytes, macrophages and activated granulocytes (1,2. A cDNA clone encoding CD14 was isolated from a cDNA expression library (3), seg,uenced and used to isolate the CD14 gene from a genomic phage library. The initiation codon is flanked by a sequence which shows homology to the consensus sequence C(C)6CCATGG for a translation initiation site defined by IKzak (4) and is separated from the rest of the coding region by an 88bp intron. The cDNA polyadenylation signal (ATTAAA) is overlined.
The Generalized Treynor Ratio: A Note

This paper presents a generalization of the Treynor ratio in a multi-index setup. The solution proposed in this paper is the simplest measure that keeps Treynor's original interpretation of the ratio of abnormal excess return (Jensen's alpha) to systematic risk exposure (the beta) and preserves the same key geometric and analytical properties as the original single index measure. The Generalized Treynor ratio is defined as the abnormal return of a portfolio per unit of weighted-average systematic risk, the weight of each risk loading being the value of the corresponding risk premium. Each risk premium is normalized to ensure the unit corresponding beta of the benchmark portfolio.
Overproduction of Sac7d and Sac7e Reveals Only Sac7e to Be a DNA-Binding Protein with Ribonuclease Activity from the Extremophilic Archaeon Sulfolobus acidocaldarius

Genomic DNA from Sulfolobus acidocaldarius was screened using a degenerate oligodeoxyribonucleotide, derived from the sequence of 16 N-terminal amino acids from SaRD protein. SaRD protein was previously isolated in our laboratory and identified as a protein from S. acidocaldarius exhibiting ribonuclease activity as well as DNA-binding properties. On the basis of Southern hybridization analysis two genes from S. acidocaldarius have been cloned, sequenced and overproduced in Escherichia coli. The deduced amino acid sequences revealed that one gene encodes Sac7d and the other one Sac7e; two small, previously described basic proteins from S. acidocaldarius, and furthermore the N-termini of Sac7e and SaRD are identical. Northern blot analysis demonstrated that the genes are transcribed separately. After expression of sac7d and sac7e genes in E. coli it was shown that only recombinant Sac7e protein exhibits RNase activity and is catalytically indistinguishable from SaRD protein. Western blot analysis using a polyclonal antiserum raised against purified SaRD protein further confirmed that Sac7e and SaRD are identical proteins endowed with RNase activity and DNA-binding properties. A new RNA cleavage mechanism has to be postulated for Sac7e since, in contrast to common RNases (e.g. RNase A and T1), no histidines are present in the amino acid sequence. Differences between the very closely related 7 kDa proteins from two Sulfolobus strains converting DNA-binding proteins into RNases are pointed out and discussed, whereas substitutions of Glu by Gln (S. solfataricus) or by Lys (S. acidocaldarius) seem to be crucial.
Early events of SARS coronavirus infection in vero cells

An isolate from a patient in the recent severe acute respiratory syndrome (SARS) outbreak in Singapore was used to infect Vero E6 cells. This study concentrated on the first 30 min of infection. It was discovered that the SARS coronavirus attached, entered, and uncoated the nucleocapsids, all within a 30‐min period. At 5 min after infection, several virus particles lined the Vero cell plasma membrane. Virus particles were at various stages of fusion at the cell surface, since entry was not a synchronised process. After entry (10 and 15 min), spherical core particles moved into the cytoplasm within large vacuoles. Quite surprising at such early stages of infection (20 min), a virus‐induced change in the infected cells was evident. The induction of myelin‐like membrane whorls was obvious within the same vacuoles as the core particles. The significance of this virus‐induced change is unknown at this stage. By 25–30 min postinfection (p.i.), the spherical core particles appeared to be disassociating and, in their place, doughnut‐shaped electron‐dense structures were observed. These could be the virus genomes together with the helical nucleocapsids. They were no longer in large vacuoles but packaged into smaller vacuoles in the cytoplasm, and occasionally in small groups. J. Med. Virol. 71:323–331, 2003. © 2003 Wiley‐Liss, Inc.
Brand personality and its outcomes in the Chinese automobile industry

The purpose of this study is to understand the relationship between ‘brand personality’ and key outcomes in the Chinese automobile industry. A secondary aim of the study is to look at whether or not these relationships hold across purchasers and non-purchasers. The major conclusion is that while brand personality dimensions are somewhat consistent across both purchasers and non-purchasers, the brand personality outcomes differ somewhat between the groups. First, brand personality plays a critical role in improving perceived quality and creating brand trust, a key finding given the intensely competitive nature of the Chinese automobile industry. Second, perceived quality plays an important role in mediating the relationship between brand personality and brand commitment for both groups. Third, perceived quality does not affect brand trust for the purchaser group. In the context of Chinese automobile industry, increasing the level of perceived quality of a particular brand requires convincing non-purchasers that the brand is valuable, and that the information being provided is useful. Fourth, since the relationship between perceived quality and brand trust was found to be non-significant, future research studies may wish to focus on obtaining a better understanding of Chinese cultural perspectives to shed further light on why perceived quality and brand trust are not related for the automobile purchaser group.
Urinary levels of vascular endothelial growth factor in patients with prostate cancer as a predictor of disease progression.

BACKGROUND The objectives of this study were to investigate the association between urinary levels of vascular endothelial growth factor (VEGF) and the progression of prostate cancer, and to evaluate changes in urinary VEGF levels before and after initial treatment. MATERIALS AND METHODS A total of 97 patients with prostate cancer were included in this study. Of these 97, 52 underwent radical prostatectomy and the remaining 45 received hormonal therapy as initial treatment. Urinary VEGF levels were measured using a sandwich enzyme immunoassay, and the results were analyzed with respect to several clinicopathological factors. RESULTS The mean urinary level of VEGF in patients with prostate cancer was significantly higher than that in healthy controls. The urinary level of VEGF in prostate cancer patients with metastasis was significantly elevated compared with that in those without metastasis. Among 52 patients who underwent radical prostatectomy, the urinary levels of VEGF in patients with pathologically organ-confined disease were significantly lower than that in those with extraprostatic disease. Furthermore, the urinary VEGF level in 52 patients after radical prostatectomy was significantly lower than that before radical prostatectomy, while there was no significant difference in urinary VEGF level in 45 patients before and after hormonal therapy. CONCLUSION These findings suggest that the elevation of urinary VEGF could be a useful predictor of disease progression in prostate cancer, and that the urinary levels of VEGF reflect the therapeutic effect of radical prostatectomy, but not that of hormonal therapy.
Perceptual Grouping Affects Haptic Enumeration Over the Fingers

Spatial arrangement is known to influence enumeration times in vision. In haptic enumeration, it has been shown that dividing the total number of items over the two hands can speed up enumeration. Here we investigated how spatial arrangement of items and non-items presented to the individual fingers impacts enumeration times. More specifically, we tested whether grouping by proximity facilitates haptic serial enumeration (counting). Participants were asked to report the number of tangible items, amongst non-items, presented to the finger pads of both hands. In the first experiment, we divided the tangible items in one, two, or three groups that were defined by proximity (i.e., one nonitem in between two groups) and found that number of groups and not number of items were the critical factor in enumeration times. In a second experiment, we found that this grouping even takes place when groups extend across fingers of both hands. These results suggest that grouping by proximity affects haptic serial enumeration and that this grouping takes place on a spatial level possibly in addition to the somatotopic level. Our results support the idea that grouping by proximity, a principle introduced in vision, also greatly affects haptic processing of spatial information.
Comparing outcomes of donation after cardiac death versus donation after brain death in liver transplant recipients with hepatitis C: a systematic review and meta-analysis.

BACKGROUND Liver transplantation (LT) using organs donated after cardiac death (DCD) is increasing due, in large part, to a shortage of organs. The outcome of using DCD organs in recipients with hepatits C virus (HCV) infection remains unclear due to the limited experience and number of publications addressing this issue. OBJECTIVE To evaluate the clinical outcomes of DCD versus donation after brain death (DBD) in HCV-positive patients undergoing LT. METHODS Studies comparing DCD versus DBD LT in HCV-positive patients were identified based on systematic searches of seven electronic databases and multiple sources of gray literature. RESULTS The search identified 58 citations, including three studies, with 324 patients meeting eligibility criteria. The use of DCD livers was associated with a significantly higher risk of primary nonfunction (RR 5.49 [95% CI 1.53 to 19.64]; P=0.009; I2=0%), while not associated with a significantly different patient survival (RR 0.89 [95% CI 0.37 to 2.11]; P=0.79; I2=51%), graft survival (RR 0.40 [95% CI 0.14 to 1.11]; P=0.08; I2=34%), rate of recurrence of severe HCV infection (RR 2.74 [95% CI 0.36 to 20.92]; P=0.33; I2=84%), retransplantation or liver disease-related death (RR 1.79 [95% CI 0.66 to 4.84]; P=0.25; I2=44%), and biliary complications. CONCLUSIONS While the literature and quality of studies assessing DCD versus DBD grafts are limited, there was significantly more primary nonfunction and a trend toward decreased graft survival, but no significant difference in biliary complications or recipient mortality rates between DCD and DBD LT in patients with HCV infection. There is insufficient literature on the topic to draw any definitive conclusions.
Differential aversive learning enhances orientation discrimination

ABSTRACT A number of recent studies have documented rapid changes in behavioural sensory acuity induced by aversive learning in the olfactory and auditory modalities. The effect of aversive learning on the discrimination of low-level features in the visual system of humans remains unclear. Here, we used a psychophysical staircase procedure to estimate discrimination thresholds for oriented grating stimuli, before and after differential aversive learning. We discovered that when a target grating orientation was conditioned with an aversive loud noise, it subsequently led to an improvement of discrimination acuity in nearly all subjects. However, no such change was observed in a control group conditioned to an orientation shifted by ±90° from the target. Our findings cannot be explained by contextual learning or sensitisation factors. The results converge with those reported in the olfactory modality and provide further evidence that early sensory systems can be rapidly modified by recently experienced reinforcement histories.
On the cytoadhesion of Plasmodium vivax-infected erythrocytes.

BACKGROUND Plasmodium falciparum and Plasmodium vivax are responsible for most of the global burden of malaria. Although the accentuated pathogenicity of P. falciparum occurs because of sequestration of the mature erythrocytic forms in the microvasculature, this phenomenon has not yet been noted in P. vivax. The increasing number of severe manifestations of P. vivax infections, similar to those observed for severe falciparum malaria, suggests that key pathogenic mechanisms (eg, cytoadherence) might be shared by the 2 parasites. METHODS Mature P. vivax-infected erythrocytes (Pv-iEs) were isolated from blood samples collected from 34 infected patients. Pv-iEs enriched on Percoll gradients were used in cytoadhesion assays with human lung endothelial cells, Saimiri brain endothelial cells, and placental cryosections. RESULTS Pv-iEs were able to cytoadhere under static and flow conditions to cells expressing endothelial receptors known to mediate the cytoadhesion of P. falciparum. Although Pv-iE cytoadhesion levels were 10-fold lower than those observed for P. falciparum-infected erythrocytes, the strength of the interaction was similar. Cytoadhesion of Pv-iEs was in part mediated by VIR proteins, encoded by P. vivax variant genes (vir), given that specific antisera inhibited the Pv-iE-endothelial cell interaction. CONCLUSIONS These observations prompt a modification of the current paradigms of the pathogenesis of malaria and clear the way to investigate the pathophysiology of P. vivax infections.
Uptake of l‐Glutamate into Rat Brain Synaptic Vesicles: Effect of Inhibitors that Bind Specifically to the Glutamate Transporter

Abstract: In this study we have described a series of new and potent inhibitors of the vesicular uptake of glutamate. The two most efficient inhibitors were the dyes Evans blue and Chicago Skye Blue 6B, which are structurally related to glutamate and were competitive inhibitors in the nanomolar range. The anion channel blocker 4,4′‐diisothiocyanostilbene‐2,2′‐disulfonic acid (SITS) and the diuretics furosemide and bumetanide are inhibitors of chloride transport in other organs but were competitive inhibitors of glutamate and noncompetitive with respect to chloride ions. Evans blue, Chicago Skye Blue 6B, SITS, furosemide, and bumetanide are all large organic acids with two centers of negative charge and an electron‐donating group at close vicinity of the negative charge at physiological pH. The inhibition of the glutamate uptake with these inhibitors was noncompetitive with respect to Cl−. The inhibitors, therefore, probably interact directly with the glutamate carrier. Bafilomycin A1, which is a specific vacuolar ATPase inhibitor, was used as a control and inhibited the vesicular dopamine, glutamate, and GABA uptake to the same extent. None of the inhibitors had any effect on the plasma membrane carrier, which is therefore clearly different from the vesicular carrier.
A performance measurement system for academic entrepreneurship: a case study

Purpose – This paper aims at proposing a performance measurement system (PMS) for academic entrepreneurship. Design/methodology/approach – The PMS has been developed through action research carried out within an Italian higher education and research centre on the basis of the literature background, focus groups and interviews. Findings – The study presents a new PMS based on an input–output model for academic entrepreneurship. As a result, a multidimensional framework for measuring technology entrepreneurship is proposed together with a set of key performance indicators (KPIs) to assess the “third mission” of universities. The application of the framework allows demonstration of its validity in public settings. Research limitations/implications – Because the research was conducted in a specific organisation, the possibility of generalizing the results to similar institutions is a key issue. Hence, it is important to distinguish between what is general in scope and what is case-specific. Practical implicat.
Finding prokaryotic genes by the 'frame-by-frame' algorithm: targeting gene starts and overlapping genes

MOTIVATION Tightly packed prokaryotic genes frequently overlap with each other. This feature, rarely seen in eukaryotic DNA, makes detection of translation initiation sites and, therefore, exact predictions of prokaryotic genes notoriously difficult. Improving the accuracy of precise gene prediction in prokaryotic genomic DNA remains an important open problem. RESULTS A software program implementing a new algorithm utilizing a uniform Hidden Markov Model for prokaryotic gene prediction was developed. The algorithm analyzes a given DNA sequence in each of six possible global reading frames independently. Twelve complete prokaryotic genomes were analyzed using the new tool. The accuracy of gene finding, predicting locations of protein-coding ORFs, as well as the accuracy of precise gene prediction, and detecting the whole gene including translation initiation codon were assessed by comparison with existing annotation. It was shown that in terms of gene finding, the program performs at least as well as the previously developed tools, such as GeneMark and GLIMMER. In terms of precise gene prediction the new program was shown to be more accurate, by several percentage points, than earlier developed tools, such as GeneMark.hmm, ECOPARSE and ORPHEUS. The results of testing the program indicated the possibility of systematic bias in start codon annotation in several early sequenced prokaryotic genomes. AVAILABILITY The new gene-finding program can be accessed through the Web site: http:@dixie.biology. gatech.edu/GeneMark/fbf.cgi CONTACT mark@amber.gatech.edu.