Miracle-dz/UniFAR-FTUs huggingface dataset:
Authorship and Plagiarism Detection Using Binary BOW Features

Identifying writing style shifts and variations are fundamental capabilities when addressing authorship related tasks. In this work we examine a simplified approach for unsupervised authorship and plagiarism detection which is based on binary bag of words representation. We evaluate our approach using PAN-2012 Authorship Attribution challenge data, which includes both open/closed class authorship identification and intrinsic plagiarism tasks. Our approach proved to be successful achieving overall average accuracy of 84% over and a 2nd place rank in the competition.
HDW: A High Performance Large Scale Data Warehouse

As data warehouses grow in size, ensuring adequate database performance will be a big challenge. This paper presents a solution, called HDW, based on Google infrastructure such as GFS, Bigtable, MapReduce to build and manage a large scale distributed data warehouse for high performance OLAP analysis. In addition, HDW provides XMLA standard interface for front end applications. The results show that HDW achieves pretty good performance and high scalability, which has been demonstrated on at least 18 nodes with 36 cores.
Progress in Spoken Programming

The dominant paradigm for programming a computer today is text entry via keyboard and mouse, but there are many common situations where this is not ideal. For example, tablets are challenging the idea that computers should include a keyboard and mouse. The virtual keyboards available on tablets are functional in terms of entering small amounts of text, but they leave much to be desired for use as a keyboard replacement. Before tablets can can become truly viable as a standalone computing platform, we need a programming environment that supports non-keyboard programming. An introduction to this research was presented at the UNM CS Student Conference in 2011 [8]. In this paper, we describe progress and lessons learned so far.
Microglia/macrophages promote glioma progression

Gliomas are highly aggressive and accompanied by numerous microglia/macrophages (MG/MP) in and about the tumor. Little is known about what MG/MP do in this setting, or whether modulating MG/MP activation might affect glioma progression. Here, we used a glioma‐microglia in culture system to establish the effects the tumor and microglia have on each other. We assessed glioma progression in vivo after MG/MP ablation or in the setting of exaggerated MG/MP activation. We show that glioma cells activate microglia but inhibit their phagocytic activities. Local ablation of MG/MP in vivo decreased tumor size and improved survival curves. Conversely, pharmacological activation of MG/MP increased glioma size through stimulating tumor proliferation and inhibiting apoptosis. In agreement with recent reports, expression of the chemokine CCL21 is enhanced after MG/MP activation and correlates with tumor growth. Taken together, our findings demonstrate that inhibition of MG/MP activation may constitute a new and effective contribution towards suppressing glioma proliferation. © 2010 Wiley‐Liss, Inc.
Design of a radix-8 / 4 / 2 FFT processor for OFDM systems

The FFT processor is a very important component in Orthogonal Frequency Division Multi-plexing(OFDM) communication system. In this paper, we propose an eﬃcient variable-length radix-8/4/2 FFT architecture for OFDM systems. The FFT processor is based on radix-8 FFT algorithm and also supports radix-4 or radix-2 FFT computation. The pipelined radix-8/4/2 butterﬂy unit computes radix-8 FFT algorithm basically. For the limitation of FFT length, if it cannot run radix-8 FFT algorithm at the last stage then it computes radix-4 or radix-2 FFT algorithm. Furthermore, proposed FFT architecture use shared-memory to minimize and simplify hardware. We are using eﬃcient In-place memory access method to maintain conﬂict-free data access and minimize memory size. Also we replace a very large lookup table with a twiddle factor generator which consumes less area then a ROM-based lookup table. The proposed FFT processor performs variable-length FFT including 64, 256, 512, 1024, 2048, 4096 and 8192 points which cover all the required FFT lengths used in 802.11a, 802.16a, DAB, DVB-T, VDSL and ADSL.
Better, Not More Expensive, Faster? The Perceived Effects of Pair Programming in Survey Data

There are many different techniques used with agile software development methods. Some of these, such as common coding guidelines and test driven development, are widely adopted and there appears to be a consensus that they can be beneficial. Others, however, are more controversial, none more so perhaps than pair programming. This technique meets resistance both from developers, who do not always wish to program with another person, and from managers, who see the sharing of a workstation as a potential barrier to programmer productivity. Its supporters, however, claim that it can have many benefits, in particular improving software quality. In this paper we look at the outcomes of previous research into the effects of pair programming and analyse some survey data to see how practitioners perceive its potential benefits for project outcomes in terms of quality, productivity, stakeholder satisfaction and cost. We conclude that the survey data appears to reinforce many of the previous claims made for the benefits of pair programming, but also raises questions that need further investigation.
A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase

Centrosomes nucleate microtubules and contribute to mitotic spindle organization and function. They also participate in cytokinesis and cell cycle progression in ways that are poorly understood. Here we describe a novel human protein called centriolin that localizes to the maternal centriole and functions in both cytokinesis and cell cycle progression. Centriolin silencing induces cytokinesis failure by a novel mechanism whereby cells remain interconnected by long intercellular bridges. Most cells continue to cycle, reenter mitosis, and form multicellular syncytia. Some ultimately divide or undergo apoptosis specifically during the protracted period of cytokinesis. At later times, viable cells arrest in G1/G0. The cytokinesis activity is localized to a centriolin domain that shares homology with Nud1p and Cdc11p, budding and fission yeast proteins that anchor regulatory pathways involved in progression through the late stages of mitosis. The Nud1p-like domain of centriolin binds Bub2p, another component of the budding yeast pathway. We conclude that centriolin is required for a late stage of vertebrate cytokinesis, perhaps the final cell cleavage event, and plays a role in progression into S phase.
Suppression of Sproutys Has a Therapeutic Effect for a Mouse Model of Ischemia by Enhancing Angiogenesis

Sprouty proteins (Sproutys) inhibit receptor tyrosine kinase signaling and control various aspects of branching morphogenesis. In this study, we examined the physiological function of Sproutys in angiogenesis, using gene targeting and short-hairpin RNA (shRNA) knockdown strategies. Sprouty2 and Sprouty4 double knockout (KO) (DKO) mice were embryonic-lethal around E12.5 due to cardiovascular defects. The number of peripheral blood vessels, but not that of lymphatic vessels, was increased in Sprouty4 KO mice compared with wild-type (WT) mice. Sprouty4 KO mice were more resistant to hind limb ischemia and soft tissue ischemia than WT mice were, because Sprouty4 deficiency causes accelerated neovascularization. Moreover, suppression of Sprouty2 and Sprouty4 expression in vivo by shRNA targeting accelerated angiogenesis and has a therapeutic effect in a mouse model of hind limb ischemia. These data suggest that Sproutys are physiologically important negative regulators of angiogenesis in vivo and novel therapeutic targets for treating peripheral ischemic diseases.
Product lattice codes

Lattice-based construction of codes is of theoretical as well as practical importance in particular for communications over bandwidth-limited channels. We investigate the so called product lattice construction. Certain fundamental properties of product lattices are derived, and it is demonstrated that their performance are comparable to those of known good lattices. Practical issues concerning encoding and decoding of product lattices are discussed.
JIT-Compiler-Assisted Distributed Java Virtual Machine

There is now a strong interest in high-performance execution of multithreaded Java programs in a cluster. Previous efforts to provide for such executions have either used static compilation tools that can transform multithreaded Java programs into parallel versions, or interpreter-based cluster-aware JVMs that offer the needed support. They failed however to be fully compliant with the Java language specification or to achieve high performance due to their weaknesses in supporting thread distribution and global object sharing. We present our research experience in the design and implementation a JIT-compiler-assisted distributed Java Virtual Machine. In our system, we make use of a JIT compiler to realize and optimize dynamic thread migration and global object sharing in a distributed environment.
A Missense Mutation of the Gene Encoding Voltage-Dependent Sodium Channel (Nav1.1) Confers Susceptibility to Febrile Seizures in Rats

Although febrile seizures (FSs) are the most common convulsive syndrome in infants and childhood, the etiology of FSs has remained unclarified. Several missense mutations of the Nav1.1 channel (SCN1A), which alter channel properties, have been reported in a familial syndrome of GEFS+ (generalized epilepsy with febrile seizures plus). Here, we generated Scn1a-targeted rats carrying a missense mutation (N1417H) in the third pore region of the sodium channel by gene-driven ENU (N-ethyl-N-nitrosourea) mutagenesis. Despite their normal appearance under ordinary circumstances, Scn1a mutant rats exhibited remarkably high susceptibility to hyperthermia-induced seizures, which involve generalized clonic and/or tonic–clonic convulsions with paroxysmal epileptiform discharges. Whole-cell patch-clamp recordings from HEK cells expressing N1417H mutant channels and from hippocampal GABAergic interneurons of N1417H mutant rats revealed a significant shift of the inactivation curve in the hyperpolarizing direction. In addition, clamp recordings clearly showed the reduction in action potential amplitude in the hippocampal interneurons of these rats. These findings suggest that a missense mutation (N1417H) of the Nav1.1 channel confers susceptibility to FS and the impaired biophysical properties of inhibitory GABAergic neurons underlie one of the mechanisms of FS.
Testing the Assumption of Uncorrelated Errors for Short Scales by Means of Structural Equation Modeling

It is shown that a minimal assumption should be added to the assumptions of Classical Test Theory (CTT) in order to have positive inter-item correlations, which are regarded as a basis for the aggregation of items. Moreover, it is shown that the assumption of zero correlations between the error score estimates is substantially violated in the population of individuals when the number of items is small. Instead, a negative correlation between error score estimates occurs. The reason for the negative correlation is that the error score estimates for different items of a scale are based on insufficient true score estimates when the number of items is small. A test of the assumption of uncorrelated error score estimates by means of structural equation modeling (SEM) is proposed that takes this effect into account. The SEM-based procedure is demonstrated by means of empirical examples based on the Edinburgh Handedness Inventory and the Eysenck Personality Questionnaire-Revised.
Side‐chain flexibility in proteins upon ligand binding

Ligand binding may involve a wide range of structural changes in the receptor protein, from hinge movement of entire domains to small side‐chain rearrangements in the binding pocket residues. The analysis of side chain flexibility gives insights valuable to improve docking algorithms and can provide an index of amino‐acid side‐chain flexibility potentially useful in molecular biology and protein engineering studies. In this study we analyzed side‐chain rearrangements upon ligand binding. We constructed two non‐redundant databases (980 and 353 entries) of “paired” protein structures in complexed (holo‐protein) and uncomplexed (apo‐protein) forms from the PDB macromolecular structural database. The number and identity of binding pocket residues that undergo side‐chain conformational changes were determined. We show that, in general, only a small number of residues in the pocket undergo such changes (e.g., ∼85% of cases show changes in three residues or less). The flexibility scale has the following order: Lys > Arg, Gln, Met > Glu, Ile, Leu > Asn, Thr, Val, Tyr, Ser, His, Asp > Cys, Trp, Phe; thus, Lys side chains in binding pockets flex 25 times more often then do the Phe side chains. Normalizing for the number of flexible dihedral bonds in each amino acid attenuates the scale somewhat, however, the clear trend of large, polar amino acids being more flexible in the pocket than aromatic ones remains. We found no correlation between backbone movement of a residue upon ligand binding and the flexibility of its side chain. These results are relevant to 1. Reduction of search space in docking algorithms by inclusion of side‐chain flexibility for a limited number of binding pocket residues; and 2. Utilization of the amino acid flexibility scale in protein engineering studies to alter the flexibility of binding pockets. Proteins 2000;39:261–268. © 2000 Wiley‐Liss, Inc.
Versatile, High-Quality Motions and Behavior Control of a Humanoid Soccer Robot

Autonomous soccer games represent an extraordinary challenge for autonomous humanoid robots which must act fast and stable while carrying all needed onboard computers, sensors and batteries. In this paper, the development and system integration of hardware and software modules of the 55-cm tall, autonomous humanoid soccer robot Bruno is described to cope with this challenge. Although based on a "minimalistic" design which only uses gyroscopes in the hip but not foot-ground contact sensors for control of balance, versatile and high-quality walking motions have been developed. Fast forward walking of about 1.5 km/h has been obtained using an efficient sequential surrogate optimization method and walking through uneven terrain with a newly designed passively compliant foot sole. Further modules of the software and control architecture which are needed for an adaptive selection of different motions and autonomous robot behavior are briefly described. Experimental results are reported, which have been obtained under the conditions of a live competition. The robot's hardware is mainly based on standard components which can therefore be easily adapted by new designers, as no comparable, standard humanoid robot platforms are available.
Building Client ’ s Risk Profile Based on Call Detail Records

Data collected from mobile phones can be used to uncover underlying social network dynamics and individual’s behavioral patterns. Based on a Call Details Records dataset, we build a weighted, directed network and analyze it’s properties. In addition to node-level network measures we extract an extensive consumption and mobility-based feature set. We show that extracted network and consumption features can be used to model individual’s risk profile.
Investigation of Glandular Trichome Proteins in Artemisia annua L. Using Comparative Proteomics

Glandular secreting trichomes (GSTs) are called biofactories because they are active in synthesizing, storing and secreting various types of plant secondary metabolites. As the most effective drug against malaria, artemisinin, a sesquiterpene lactone is derived from GSTs of Artemisia annua. However, low artemisinin content (0.001%∼1.54% of dry weight) has hindered its wide application. We investigate the GST-expressed proteins in Artemisia annua using a comparative proteomics approach, aiming for a better understanding of the trichome proteome and arteminisin metabolism. 2D-electrophoresis was employed to compare the protein profiles of GSTs and leaves. More than 700 spots were resolved for GSTs, of which ∼93 non-redundant proteins were confidently identified by searching NCBI and Artemisia EST databases. Over 70% of these proteins were highly expressed in GTSs. Functional classification of these GSTs enriched proteins revealed that many of them participate in major plant metabolic processes such as electron transport, transcription and translation.
Preliminary validation and clinical meaning of the Cutaneous Assessment Tool in juvenile dermatomyositis.

OBJECTIVE To provide preliminary validation of the Cutaneous Assessment Tool (CAT), a new tool to assess cutaneous manifestations of juvenile dermatomyositis (DM), and to explore the clinical meaning of CAT scores. METHODS Children with juvenile DM (n = 113) were assessed at baseline and 7-9 months later (n = 94). Internal consistency, redundancy, construct validity, and responsiveness of the CAT were examined. CAT scores corresponding to ordinal global assessments were determined. RESULTS Item-total correlations ranged from 0.27-0.67 for activity lesions present in > or =10% of patients; item-domain and domain-total correlations ranged from 0.25-0.99. Cronbach's alpha was 0.79 for the CAT activity score and 0.74 for the CAT damage score. As predicted, the CAT activity score correlated strongly with both global disease activity and skin disease activity and moderately with the Childhood Myositis Assessment Scale, whereas the CAT damage score correlated moderately with the physician global disease and skin disease damage scores. Median CAT activity scores of 1, 7, 13, 18, and 31 corresponded to absent, mild, moderate, severe, and extremely severe skin disease activity, respectively. Median CAT damage scores of 0, 1, 2, and 5 correlated with the same descriptions of damage (severe and extremely severe combined). CONCLUSION Preliminary validation of the CAT demonstrated good internal consistency, nonredundancy, good construct validity, and appropriate responsiveness. The CAT is a comprehensive, semiquantitative assessment tool for skin disease in juvenile DM.
Approximating Personalized PageRank with Minimal Use of Web Graph Data

In this paper, we consider the problem of calculating fast and accurate approximations to the personalized PageRank score of a webpage. We focus on techniques to improve speed by limiting the amount of web graph data we need to access. Our algorithms provide both the approximation to the personalized PageRank score as well as guidance in using only the necessary information—and therefore sensibly reduce not only the computational cost of the algorithm but also the memory and memory bandwidth requirements. We report experiments with these algorithms on web graphs of up to 118 million pages and prove a theoretical approximation bound for all. Finally, we propose a local, personalized web-search system for a future client system using our algorithms.
Role of the Vtc proteins in V-ATPase stability and membrane trafficking

Vtc proteins have genetic and physical relations with the vacuolar H+-ATPase (V-ATPase), influence vacuolar H+ uptake and, like the V-ATPase V0 sectors, are important factors in vacuolar membrane fusion. Vacuoles from vtc1Δ and vtc4Δ mutants had slightly reduced H+-uptake activity. These defects could be separated from Vtc function in vacuole fusion, demonstrating that Vtc proteins have a direct role in membrane fusion. We analyzed their involvement in other membrane trafficking steps and in VATPase dynamics. Deletion of VTC genes did not impede endocytic trafficking to the vacuole. However, ER to Golgi trafficking and further transport to the vacuole was delayed in Δvtc3 cells. In accordance with that,Δ vtc3 cells showed a reduced growth rate. Vtc mutations did not interfere with regulated assembly and disassembly of the V-ATPase, but they affected the number of peripheral V1 subunits associated with the vacuoles. Δvtc3 vacuoles carried significantly more V1 subunits, whereas Δvtc1, Δvtc2 andΔ vtc4 had significantly less. The proteolytic sensitivity of the V0 subunit Vph1p was different in Δvtc and wild-type cells in vivo, corroborating the physical interaction of Vtc proteins with the V-ATPase observed in vitro. We suggest that Vtc proteins affect the conformation of V0. They might thereby influence the stability of the VATPase holoenzyme and support the function of its V0 sector in vacuolar membrane fusion.
Theater-system Technique and Model-based Attention Prediction for the Early Automotive HMI Design Evaluation

Automotive HMI design evaluation methods, such as usability assessments, attention and reaction time measurements require full working HMI prototypes to assess the usability and the subjects' performances in realistic situations. The theater-system technique and model-based prediction methods do not depend on functional HMI implementations and therefore promise HMI evaluation already in an early design phase. We applied both methods to evaluate three HMI designs for an Urban Adaptive Cruise Control (ACC) System. In a qualitative study with twelve participants, we used a theater-system-based technique to let them experience the HMIs in realistic situations. Subjects clearly preferred the HMI variant, which offers the best understanding of the vehicle's automation. By following a model-based approach, we evaluated the impacts to the driver's visual attention distribution of the three HMI variants with six human factor experts and found significant attention changes for the front window and for the Urban ACC HMI.
COPING E SOBRECARGA NOS CUIDADORES INFORMAIS DE PESSOAS COM DOENÇA DE ALZHEIMER

The objective of this study is to know the relationships between the coping strategies the informal caregivers of people with Alzheimer's Disease use and the level of burden they experience. A sample of 62 caregivers was questioned, 32 were females and 30 were males. The average of ages is 49.89 and SD is 20.25. A social demographic questionnaire was used, the Barthel Index )Mahoney & Barthel, 1965) was also used to establish the degree of independence of the person with AD, the Questionario de Avaliacao da Sobrecarga do Cuidador Informal (Martins, Ribeiro & Garrett, 2003) was used to measure the level of burden, and the Brief COPE (Carver, 1997) to measure the coping strategies more frequently used. As for the results, there is a direct correlation between the scale Behavioural Disengagement and the scale Financial Burden, and also with the scale Implications on Personal Life. The coping strategy that the questioned caregivers use more often is Positive Reframing (M= 3.56) and the one used less frequently is Substance Use (M= 1.19). The caregivers that use Positive Reframing more often are the ones that have been caregivers for less time. There are no high levels of burden among the questioned caregivers. In conclusion, the caregivers that have more financial difficulties are the ones that more often give up on trying to improve their situation, and also, the ones whose lives and plans were more altered by the caregiving situation are more prone to giving up on their plans and goals. The caregivers that are so more recently, have less difficulty in coping with the situation, therefore the duration of the caregiving seems to have an important role on the experienced burden.