Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Histone Deacetylation in Developmentally Programmed DNA Rearrangements in Tetrahymena thermophila

ABSTRACT In Tetrahymena, as in other ciliates, development of the somatic macronucleus during conjugation involves extensive and reproducible rearrangements of the germ line genome, including chromosome fragmentation and excision of internal eliminated sequences (IESs). The molecular mechanisms controlling these events are poorly understood. To investigate the role that histone acetylation may play in the regulation of these processes, we treated Tetrahymena cells during conjugation with the histone deacetylase inhibitor trichostatin A (TSA). We show that TSA treatment induces developmental arrests in the early stages of conjugation but does not significantly affect the progression of conjugation once the mitotic divisions of the zygotic nucleus have occurred. Progeny produced from TSA-treated cells were examined for effects on IES excision and chromosome breakage. We found that TSA treatment caused partial inhibition of excision of five out of the six IESs analyzed but did not affect chromosome breakage at four different sites. TSA treatment greatly delayed in some cells and inhibited in most the excision events in the developing macronucleus. It also led to loss of the specialized subnuclear localization of the chromodomain protein Pdd1p that is normally associated with DNA elimination. We propose a model in which underacetylated nucleosomes mark germ line-limited sequences for excision.
Linköping: Cubic-Time Graph Parsing with a Simple Scoring Scheme

We turn the Eisner algorithm for parsing to projective dependency trees into a cubictime algorithm for parsing to a restricted class of directed graphs. To extend the algorithm into a data-driven parser, we combine it with an edge-factored feature model and online learning. We report and discuss results on the SemEval-2014 Task 8 data sets (Oepen et al., 2014).
Restricting information flow in security APIs via typing

Security APIs are designed to enable the storage and processing of confidential data without that data becoming known to individuals who are not permitted to obtain it, and are central to the operation of Automated Teller Machines (ATM) networks, Electronic Point of Sale (EPOS) terminals, set-top boxes for subscription-based TV, pre-payment utility meters, and electronic ticketing for an increasing number of public transport systems (e.g., Oyster in London). However, since the early 2000s, it has become clear that many of the security APIs in widespread use contain subtle flaws which allow malicious individuals to subvert the security restrictions and obtain confidential data that should be protected. In this thesis, we attempt to address this problem by presenting a type system in which specific security properties are guaranteed to be enforced by security APIs that are well-typed. Since type-checking is a form of static analysis, it does not suffer from the scalability issues associated with approaches that simulate interactions between a security API and one or more malicious individuals. We also show how our type system can be used to model an existing security API and provide the same guarantees of security that the API authors proved it upholds. This result follows directly from producing a well-typed implementation of the API, and demonstrates how our type system provides security guarantees without requiring additional API-specific proofs.
Prior knowledge, cognitive characteristics and opportunity recognition

Purpose – In order to answer why and how some individuals identify opportunities, the purpose of this paper is to offer a comprehensive framework of key effective factors that investigates the role of prior knowledge and cognitive characteristics of entrepreneurial alertness and learning in the entrepreneurial opportunities recognition process. Design/methodology/approach – First, the authors identified key effective factors and developed research hypotheses and conceptual model. Second, the authors considered research methodology including sampling and data collection, measurement model. The third section presents a report of the results from the analysis of the structural model and the hypotheses tests. Findings – The findings show that all the three factors had positive impact on opportunity recognition. It is also confirmed that prior knowledge has significant impact on entrepreneurial alertness and learning. Finally, the results demonstrate that both entrepreneurial alertness and learning partially m.
Coercion-Resistant Electronic Elections with Write-In Candidates

It is often argued in the e-voting community that in the presence of write-in candidates, forced abstention attacks are always possible. Therefore, write-in candidates are often excluded in existing definitions of coercion-resistance arguing that those definitions cannot be achieved by write-in supporting schemes. This is only true if the tally is made public directly. Coercion-resistance may well be achieved if only a fuzzy version of the tally is published. This paper provides a formalization of fuzzy tally representations which enables definitions for coercion-resistance to take into account write-in candidates without being weakened. We also show how the cryptographic voting scheme Bingo Voting can be applied to write-in candidates with respect to this formalization, providing what we believe to be the first e-voting scheme that prevents forced abstention while allowing for write-in candidates. We then give a general construction of coercion-resistant schemes that provide a verifiable fuzzy tally representation from mix-based and homomorphic election schemes with trusted authority.
A Parallel NIDS Pattern Matching Engine and Its Implementation on Network Processor

At the heart of almost every modern Network Intrusion Detection System (NIDS), there is a pattern matching engine (PME). As pattern matching is the most time consuming operation in NIDS, it is highly desired to reduce the pattern matching time of each packet or flow. This paper proposed a parallel pattern matching algorithm based on Aho-Corasick (AC) algorithm and an efficient load balance policy for it. The method is implemented on Intel’s IXP2850 Network Processor (NP). Experimental results show that when using eight processors, the pattern matching time of each packet or flow can decrease to 60.44%~14.42% of using only one processor. Based on the parallel algorithm, a PME utilizing parallel processing on three levels is proposed. Experimental results on IXP2850 show that the throughput speedup of pattern matching is 13.34~55.48 times.
Andrew G Haldane: The race to zero

Stock prices can go down as well as up. Never in financial history has this adage been more apt than on 6 May 2010. Then, the so-called “Flash Crash” sent shocks waves through global equity markets. The Dow Jones experienced its largest ever intraday point fall, losing $1 trillion of market value in the space of half an hour. History is full of such fat-tailed falls in stocks. Was this just another to add to the list, perhaps compressed into a smaller time window?
Restricted gene flow between Holothuria scabra (Echinodermata: Holothuroidea) populations along the north-east coast of Australia and the Solomon Islands

To describe patterns of gene flow for the fished holothurian species Holothuria scabra 17 to 141 individuals were collected from 8 populations from north-east Australia, the Torres Strait, and the Solomon Islands. Samples were investigated by allozyme electrophoresis of 7 polymorphic loci. Cluster analyses using Rogers' genetic distance identified 3 distinct groups of populations from the north-east coast of Australia, representing samples from the 3 regions Hervey Bay, Upstart Bay and Torres Strait. Populations in the latter region were closely connected to those from the Solomon Islands. F-statistics indicated restrictions in gene flow (average genetic variation between popula- tions, FST = 0.088). Hierarchical analyses revealed that 94.7% of the variation was within sampling locations. Approximately 77% of the variance among populations was due to differences between regions, and 23% within regions (most of the latter caused by differences between the 2 Solomon Island populations). Mantel's tests indicated that a high proportion of the variation in genetic dis- tances along the north-east coast of Australia was explained by isolation by distance (Mantel's nor- malised Z = 0.88). This proportion reduced when the Solomon Islands were included (Z = 0.65). The detection of separate stocks along the north-east coast of Australia is an important finding that has significant consequences for the development of sustainable management plans for this species. Low dispersal may significantly reduce recovery of overfished areas if no local refugia are provided.
The Holocaust in Palestinian Textbooks

The article explores how the Holocaust is represented in history textbooks for Palestinian pupils in the Palestinian and Arab-Israeli curricula from a pedagogical perspective. Since no mention of the Holocaust was found in Palestinian Authority textbooks, the study seeks to explain why this is so, while examining representations of the Holocaust in the Arab (Palestinian) Israeli textbooks. It pursues four principal objectives: (1) to investigate the extent to which Israeli and Palestinian history textbooks discuss the Holocaust, (2) to examine how it is portrayed, (3) to contextualize these portrayals in relation to collective memories of other events (e.g., the Nakba), and (4) to consult with Israeli and Palestinian curriculum policy makers regarding the inclusion or omission of the Holocaust from the curriculum.
Nano-Sim: simulating electromagnetic-based nanonetworks in the network simulator 3

The progress of nanotechnology is paving the way to the emerging concept of wireless nanosensor network (WNSN). In fact, it is now possible to create integrated machines at the nano scale, which interact on cooperative basis using wireless communications. The research in this field is still in an embryonal stage and the design of the WNSN protocol suite represents a fundamental issue to address. Therefore, an open source simulation framework for WNSN would be highly beneficial to let research activities converge towards participated design methodologies. In an our recent work, we presented a new NS-3 module, namely Nano-Sim, modeling WNSNs based on electromagnetic communications in the Terahertz band. In its preliminary version, Nano-Sim provides a simple network architecture and a protocol suite for such an emerging technology. In this paper, we significantly improved our previous work in several directions. First, we have extended the tool by developing a new routing algorithm and a more efficient MAC protocol. Moreover, focusing the attention on a WNSN operating in a health monitoring scenario, we have investigated how the density of nodes, the transmission range of nanomachines, and the adoption of specific combinations of routing and MAC strategies may affect the network behavior. Finally, a study on Nano-Sim computational requirements has been also carried out, thus demonstrating how the developed module guarantees great achievements in terms of scalability.
Corneal Endothelial Cytotoxicity of Riboflavin/UVA Treatment in vitro

Recently, we have developed collagen crosslinking induced by combined riboflavin/UVA treatment, thus increasing the biomechanical rigidity of the cornea to treat progressive keratoconus. The present safety study was performed to evaluate possible cytotoxic effects of combined riboflavin/UVA treatment on the corneal endothelium in vitro. Endothelial cell cultures from porcine corneas were treated with 500 µM riboflavin solution, exposed to various endothelial UVA irradiances (370 nm) ranging from 0.1 to 1.6 mW/cm2 for 30 min and evaluated 24 h later using trypan blue staining and Yopro fluorescence staining. The effect of either treatment alone (UVA irradiation ranging from 0.2 to 6 mW/cm2) was also tested. An abrupt cytotoxic threshold irradiance level was found at 0.35 mW/cm2 after combined treatment with riboflavin plus UVA irradiation and at 4 mW/cm2 with UVA irradiation alone. Riboflavin alone was not toxic. A cytotoxic effect of the combined riboflavin/UVA treatment on corneal endothelial cells is to be expected with a corneal thickness of less than 400 µm. Therefore, pachymetry should be routinely performed before riboflavin/UVA treatment to exclude patients at risk.
Contagion and efficiency in gross and net interbank payment systems

The increased fragility of the banking industry has generated growing concern about the risks associated with the payment systems. Although in most industrial countries different interbank payment systems coexist, little is really known about their propierties in terms of risk and efficiency. We tackle this question by comparing the two main types of payment systems, gross and net, in a framework where uncertainty arises from several sources: the time of consumption, the location of consumption and the return on investment. Payments across locations can be made either by directly transferrring liquidity or by transferring claims against the bank in the other location. The two mechanism are interpreted as the gross and net settlement systems in interbank payments. We characterize the equilibria in the two systems and identify the trade-off in terms of safety and efficiency.
Modeling and simulation of a photovoltaic system: An advanced synthetic study

This paper focuses on modeling and simulation of a buck converter based on a PV standalone system. This advanced synthetic study includes PV generator modeling with parameters identification, an improved P&O (Perturb and Observe) algorithm with adaptive increment step and a detailed approach of DC-DC converter modeling. A thorough method is used to determine parameters for PI current controller. The set was used to simulate a whole photovoltaic conversion chain under Matlab/Simulink environment. A special focus has been dedicated to the influence of solar irradiation variations on converter dynamic and behavior as a range of PV current 0-8 A was considered. Simulation results confirm stability, accuracy and speed response of synthesized regulator and MPPT algorithm employed. Dynamic analyses show that the more restricting control concerns low values of current Ipv (low irradiation). This work will be useful for PhD students and researchers who need an effective and straightforward way to model and simulate photovoltaic systems.
Anomalous compressibility effects and superconductivity of EuFe2As2 under high pressures

The crystal structure and electrical resistance of structurally layered EuFe2As2 have been studied up to 70 GPa and down to a temperature of 10 K, using a synchrotron x-ray source and designer diamond anvils. The room temperature compression of the tetragonal phase of EuFe2As2 (I4/mmm) results in an increase in the a-axis length and a rapid decrease in the c-axis length with increasing pressure. This anomalous compression reaches a maximum at 8 GPa and the tetragonal lattice behaves normally above 10 GPa, with a nearly constant c/a axial ratio. The rapid rise in the superconducting transition temperature (Tc) to 41 K with increasing pressure is correlated with this anomalous compression, and a decrease in Tc is observed above 10 GPa. We present P–V data or the equation of state for EuFe2As2 both in the ambient tetragonal phase and in the high pressure collapsed tetragonal phase up to 70 GPa.
RCA: experiences with an IDE annotation tool

Ink annotation is a common method for recording feedback on a paper document. However, reviewing code on paper is difficult due to its non-linear nature. This project extends existing research ideas to develop a digital ink annotation tool within an Integrated Development Environment (IDE). The aim is to provide code reviewers with an effective tool for directly commenting on code within the IDE. We describe scenarios where ink annotation would provide benefits, along with requirements and our implementation of the Rich Code Annotation Tool (RCA).
A distributed joint scheduling and power control algorithm for multicasting in wireless ad hoc networks

This paper addresses the problem of power control in ad hoc networks supporting multicast traffic. First, we present a distributed algorithm which, given the set of multicast transmitters and their corresponding receivers, provides an optimal solution to the power control problem, if there is any. The transmit power levels obtained by solving the optimization problem minimize the network power expenditure while meeting the requirements of the SNR at the receivers. Whenever no optimal solution can be found for the given set multicast transmitters, we introduce a joint scheduling and power control algorithm, which eliminates the strong interferers thus allowing the other transmitters to solve the power control problem. The algorithm can be implemented in a distributed manner; however, it provides a sub-optimal solution since it is based on local information. Simulation results show that the obtained solution is close to the global optimum, when it exists. When there is no optimal solution, the proposed algorithm tries to maximize the number of successful multicast transmission.
Data Mining Methods for Discovering Interesting Exceptions from an Unsupervised Table

In this paper, we survey efforts devoted to discovering interesting excep- tions from data in data mining. An exception differs from the rest of data and thus is interesting and can be a clue for further discoveries. We classify methods into exception instance discovery, exception rule discovery, and exception structured-rules discovery and give a condensed and comprehensive introduction.
The Effect of Field-Dependency and Seductive Augmentation on Achievement and Computer Self-Efficacy in a Virtual World

The Effect of Field-Dependency and Seductive Augmentation on Achievement and Computer Self-Efficacy in a Virtual World. (December 2011) Zahra Moghadasian Rad, B.A., Tehran University; M.A., Tehran University; M.S., Texas A&M University Co-chairs of Advisory Committee: Dr. Ronald Zellner Dr. B. Stephen Carpenter, II Keeping a learner interested—and therefore engaged—in content to be mastered generally improves learning. One way to keep a learner interested is using seductive augmentation, which refers to the addition of entertaining text, graphics, sound, music, video or animation that is either irrelevant or only tangentially relevant to the learning objectives. Learner cognitive styles impact how individuals approach learning and problemsolving situations. With recent advances in technology, there has been an increased interest in the way such individual differences influence performance while learning. Research on the effects of cognitive styles has mainly focused on the role of fielddependence/independence. One of the recent advances in technology is the availability of virtual worlds as learning environments. This study investigated whether seductive augmentation in Second Life, a commonly used virtual world, affects the learning performance of field-
Postsuburban California: The Transformation of Orange County since World War II.

The Emergence of Postsuburbia: An Introduction, Rob Kling, Spencer Olin, and Mark Poster The Multinucleated Metropolitan Region: A Comparative Analysis, M. Gottdienerand George Kephart Designing the Model Community: The Irvine Company and Suburban Development, 1950-88, Martin Schiesl The Information Labor Force, Rob Kling and Clark Turner Changing Consumption Patterns, Alladi Venkatesh Public Ceremony in a Private Culture: Orange County Celebrates the Fourth ofJuly, Debra Gold Hansen and Mary P. Ryan Narcissism or Liberation? Child Raising inthe Affluent Middle-Class Family, Mark Poster Intraclass Conflict and the Politics of aFragmented Region, 1945-88, Spencer Olin Grass-Roots Protest and the Politics of Planning: Santa Ana, 1976-88, Lisbeth Haas The Taxpayers' Revolt, William Gayk
Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart.

AIMS Recent evidence indicates that the activity of energy-dissipating ion channels in the mitochondria can influence the susceptibility of the heart to ischaemia-reperfusion injury. In this study, we describe the effects of 4'-chlorodiazepam (4-ClDzp), a well-known ligand of the mitochondrial benzodiazepine receptor, on the physiology of both isolated cardiomyocytes and intact hearts. METHODS AND RESULTS We used current- and voltage-clamp methods to determine the effects of 4-ClDzp on excitation-contraction coupling in isolated rabbit heart cells. At the level of the whole heart, we subjected rabbit hearts to ischaemia/reperfusion in order to determine how 4-ClDzp influenced the susceptibility to arrhythmias and contractile dysfunction. In isolated rabbit cardiomyocytes, 4-ClDzp evoked a significant reduction in the cardiac action potential that was associated with a decrease in calcium currents and peak intracellular calcium transients. In intact perfused normoxic rabbit hearts, 4-ClDzp mediated a dose-dependent negative inotropic response, consistent with the observation that 4-ClDzp was reducing calcium influx. Hearts that underwent 30 min of global ischaemia and 30 min of reperfusion were protected against reperfusion arrhythmias and post-ischaemic contractile impairment when 4-ClDzp (24 microM) was administered throughout the protocol or as a single bolus dose given at the onset of reperfusion. In contrast, hearts treated with cyclosporin-A, a classical blocker of the mitochondrial permeability transition pore, were not protected against reperfusion arrhythmias. CONCLUSION The findings indicate that the effects of 4-ClDzp on both mitochondrial and sarcolemmal ion channels contribute to protection against post-ischaemic cardiac dysfunction. Of clinical relevance, the compound is effective when given upon reperfusion, unlike other pre-conditioning agents.
Congenital branchial apparatus malformation in a Haflinger colt.

OBJECTIVE To report the diagnosis and treatment of a branchial apparatus anomaly (BAA) associated with a mandibular malformation in a foal. DESIGN Clinical report. ANIMAL Haflinger foal. METHODS A 6-day-old foal had a fluctuating cystic mass in the pharyngeal (throatlatch) region, which changed in appearance after ingestion of milk. Upper airway endoscopy and diagnostic imaging (ultrasonography, radiography, computed tomography) permitted identification of the anatomic location of a communicating tract between the lumen of the cystic mass and the pharynx. The mass was surgically removed and communication with the pharynx ligated. Histologic appearance of this mass was consistent with a branchial cyst or sinus. The mandibular malformation was managed conservatively. RESULTS Surgical resection of a third branchial sinus resulted in an excellent functional and cosmetic outcome. There was no evidence of any mandibular deformity 2 years later. CONCLUSION BAA may induce secondary mandibular deformation in utero and may cause respiratory compromise postpartum. Careful surgical dissection and removal of BAA resulted in an excellent outcome. CLINICAL RELEVANCE BAAs should be included in the differential diagnosis of a throatlatch region mass in equine neonates. Complete surgical excision is recommended and full recovery of any associated mandibular deformity may be anticipated without additional treatment in very young patients.
CommonKnowledge PT Critically Appraised Topics School of Physical Therapy 2014 The Effect of Pre-operative Exercises , Education and Pain Control for Patients Undergoing a Total Hip Arthroplasty

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