Miracle-dz/UniFAR-FTUs huggingface dataset:
&agr;-DEFENSIN-LIKE PRODUCT AND ASYMMETRIC DIMETHYLARGININE INCREASE IN MESENTERIC LYMPH AFTER HEMORRHAGE IN ANESTHETIZED RAT

Mesenteric lymph contains unidentified proinflammatory mediators that increase in concentration after hemorrhage. In the search for candidate mediators, we examined mesenteric lymph for the presence of proinflammatory substances that are known to be produced in the gut: (a) antimicrobial peptides and antimicrobial proteins produced in the Paneth cells of the intestine (&agr;-defensin 4, secretory phospholipase A2 [sPLA2], and Reg 2 protein) and (b) asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NOS. Anesthetized male rats were hemorrhaged to 40 mmHg and maintained at that pressure by intermittent blood withdrawal until the pressure fell to less than 40 mmHg (decompensation) at which point they were resuscitated with three times the shed blood volume of Ringer's lactate solution administered over 1 h. Mesenteric lymph samples were analyzed for ADMA by enzyme-linked immunosorbent assay and for &agr;-defensin 4, sPLA2, and Reg2 by Western blotting. Protein concentration in lymph was unchanged by hemorrhage, but &agr;-defensin 4 increased significantly (12-fold greater than control) as did ADMA (2-fold greater than control). The sPLA2 could not be detected in lymph, and Reg 2 was unchanged during hemorrhage. During resuscitation, lymph flow tended to increase, but the concentration of ADMA and &agr;-defensin 4 by volume did not increase. Reg 2 decreased during resuscitation. The results indicate that ADMA and immunoreactive product to &agr;-defensin 4 may contribute to the increase in inflammatory activity of mesenteric lymph during hemorrhage, but they are unlikely to be the mediators responsible for the increase in the concentration of inflammatory mediators in postresuscitation lymph.
Imaging and reliability of capacitive RF MEMS switches in III-V technology

In this work, the bridge imaging and the reliability of surface-micromachined capacitive RF MEMS switches in III-V technology are presented. A low cost scanning technique allowed us to image the shape of the moveable bridge with a micrometer spatial resolution, thus quantitatively valuating its lowering as a function of the applied voltage. The reliability of the switches was tested under the application of different unipolar and bipolar voltage waveforms, showing that a significant improvement of the switch operation and lifetime can be achieved by applying high frequency bipolar square pulses with suitable durations.
Degradative capacities and 16S rRNA-targeted whole-cell hybridization of sulfate-reducing bacteria in an anaerobic enrichment culture utilizing alkylbenzenes from crude oil

A mesophilic sulfate-reducing enrichment culture growing anaerobically on crude oil was used as a model system to study which nutritional types of sulfate-reducing bacteria may develop on original petroleum constituents in oil wells, tanks, and pipelines. Chemical analysis of oil hydrocarbons during growth revealed depletion of toluene and o-xylene within 1 month and of m-xylene, o-ethyltoluene, m-ethyltoluene, m-propyltoluene, and m-isopropyltoluene within approximately 2 months. In anaerobic counting series, the highest numbers of CFU (6 x 10(6) to 8 x 10(6) CFU ml-1) were obtained with toluene and benzoate. Almost the same numbers were obtained with lactate, a substrate often used for detection of the vibrio-shaped, incompletely oxidizing Desulfovibrio sp. In the present study, however, lactate yielded mostly colonies of oval to rod-shaped, completely oxidizing, sulfate-reducing bacteria which were able to grow slowly on toluene or crude oil. Desulfovibrio species were detected only at low numbers (3 x 10(5) CFU ml-1). In agreement with this finding, a fluorescently labeled, 16S rRNA-targeted oligonucleotide probe described in the literature as specific for members of the Desulfovibrionaceae (suggested family) hybridized only with a small portion (< 5%) of the cells in the enrichment culture. These results are consistent with the observation that known Desulfovibrio species do not utilize aromatic hydrocarbons, the predominant substrates in the enrichment culture. All known sulfate-reducing bacteria which utilize aromatic compounds belong to a separate branch, the Desulfobacteriaceae (suggested family). Most members of this family are complete oxidizers. For specific hybridization with members of this branch, the probe had to be modified by a nucleotide exchange. Indeed, this modified probe hybridized with more than 95% of the cells in the enrichment culture. The results show that completely oxidizing, alkylbenzene-utilizing sulfate-reducing bacteria rather than Desulfovibrio species have to be considered in attempts to understand the microbiology of sulfide production in oil wells, tanks, and pipelines when no electron donors other than the indigenous oil constituents are available.
A user centered ubiquitous government design framework

The immense progress in information and communication technologies especially in the last two decades that boosted mobile technology and enhanced its infrastructures added to the exceptional success achieved through electronic government projects in most occasions, raised citizens' demands for government services access to be provided any where any time by any means possible and to be aware of their contexts, in what researchers calls ubiquitous access, To achieve this kind of services a new design paradigm that goes from requirements elicitation to services delivery is needed, a paradigm that makes use of the new contextual data that defines the services' use the issue we will be treating in this paper where we will be presenting a user centered design approach to ubiquitous e-government services design since ubiquitous technology is highly attached and affected by its users.
Biomedical image visualization research using the Visible Human Datasets

The practice of medicine and conduct of research in major segments of the biologic sciences have always relied on visualizations to study the relationship of anatomic structure to biologic function. Traditionally, these visualizations have either been direct, via vivisection and postmortem examination, or have required extensive mental reconstruction. The revolutionary capabilities of 3‐D and 4‐D medical imaging modalities, together with computer reconstruction and rendering of multidimensional medical and histological volume image data, obviate the need for physical dissection or abstract assembly. The availability of the Visible Human Datasets from the National Library of Medicine, coupled with the development of advanced computer algorithms to accurately and rapidly process, segment, register, measure, and display high resolution 3‐D images, has provided a rich opportunity to help advance these important new imaging, visualization, and analysis methodologies from scientific theory to clinical practice. Clin. Anat. 19:240–253, 2006. © 2006 Wiley‐Liss, Inc.
Measuring bias in international news: a large-scale analysis of news agency coverage of the Ukraine crisis

I present a new methodological approach to measuring news bias, aiming to settle the disagreement on how to define and measure bias in media and communication studies in this thesis. Unlike earlier research on TV news or newspapers, I choose international news agencies’ coverage of the Ukraine crisis in this study as a case to highlight the strength of the new approach. Utilizing newly-developed geographical news classification and sentiment analysis techniques, I analyse news coverage of the Ukraine crisis by Russia’s official news agency, ITAR-TASS, along with the independent news agency, Interfax, over two years to estimate partisan news bias resulting from stateownership. In this longitudinal content analysis, I focus on the change in sentiment of ITAR-TASS’s news coverage of Ukraine relative to Interfax’s coverage during periods following six key events in the crisis. The analysis shows that the sentiment of ITAR-TASS’s news on Ukraine’s democracy and sovereignty changed significantly after key events, reflecting the desirability of these events to the Russian government. ITAR-TASS’s news coverage became the most negative when the new Ukraine government launched military operations against pro-Russian separatists in east Ukraine, claiming that the revolution was instigated by Ukrainian fascists, who threatened the safety of ethnic Russians. This result indicates that the Russian government utilized the news agency for international propaganda to justify its actions. Further, an additional content analysis including western news agencies revealed that Reuters’s news coverage of the Ukraine crisis during this period was strongly correlated with ITAR-TASS, being influenced by the Russian government’s false statements on Ukraine. Reuters news stories were circulated internationally, and published in the most popular news sites in the United States without context. I argue that the publication of the Russian government’s false narratives by American online news sites through Reuters indicates the vulnerability of today’s international news gathering and distribution system, and the rapidly changing relationship between states and corporations in the global news industry. This suggests that western news agencies’ use of temporary correspondents in covering rapidly developing international crises increases the risk of spreading false information globally. In this case, western news agencies are, in effect, supporting international propaganda by non-western states.
Selective translocation of annexins during intracellular redistribution of Chlamydia trachomatis in HeLa and McCoy cells

When Chlamydia trachomatis elementary bodies enter epithelial cells, they occupy membrane-bound vesicles that aggregate with each other in a calcium-dependent manner but that do not fuse with lysosomes. As members of the annexin family of calcium- and membrane-binding proteins have been implicated in mediating calcium-regulated membrane traffic during endo- and exocytosis, we examined the intracellular localization of certain annexins following invasion of HeLa and McCoy cells by C. trachomatis serovar L2. Immunofluorescence staining with a panel of polyclonal antibodies against five human annexins revealed that annexins III, IV, and V translocate within the cytoplasm to the proximity of intracellular chlamydiae whereas the distribution of annexins I and VI was unaffected. The distinct distribution of annexins I and III was further analyzed by confocal microscopy, which revealed an intimate association between chlamydial aggregates or inclusions and annexin III. Confocal microscopy also confirmed the nonassociation of annexin I with chlamydial aggregates. Depletion of intracellular Ca2+ did not prevent association of annexin III with individual elementary body-containing endosomes but did prevent formation of chlamydial aggregates and translocation of annexin III. Furthermore, chloramphenicol-treated cells also showed association between chlamydial aggregates and annexin III, indicating that the annexins are of host cell origin. These data suggest that certain cytosolic annexins may be involved in the Ca(2+)-dependent aggregation and fusion of chlamydia-containing vesicles. The fact that these Ca(2+)-binding proteins differ in their ability to associate with chlamydia-containing vesicles and inclusions implies that the factors that regulate the interaction of annexin I and annexin III with membrane are different and suggests a selective regulatory mechanism for endosome aggregation and avoiding lysosome fusion during chlamydia infection.
Between resistance and resilience: a study of flood risk management in the Don catchment area (UK)

ABSTRACT The river Don catchment area in Sheffield and Rotherham offers a good place for a case study of flood risk management, given the impact of a flooding event in 2007 and the way in which local events have become entwined with national and international policy shifts. To interpret local policy, a combination of systems-based and socio-cultural theory is used. Both the theories and the case study serve to disentangle the multiple meanings of resilience. Understood in opposition to flood resistance, resilience has only limited applicability in an area such as the case study where engineering works protect employment and infrastructure. Resilience as a policy discourse also lacks political transparency and a recognition of socio-cultural influences. Underlying the shift towards resilient styles of management is an appreciation of the importance of capacity, to learn and to act. The case study identifies blockages to the realisation of that capacity.
The comorbid relationship between migraine and epilepsy: a systematic review and meta‐analysis

A number of studies have suggested a pathophysiologic link between migraine and epilepsy. Our aim was to examine the relative lifetime prevalence of migraine in people with epilepsy (PWE) as well that of epilepsy in migraineurs. We carried out a systematic review, searching five electronic databases, specified bibliographies and conference abstracts in order to identify population‐based studies that measured the lifetime co‐prevalence of migraine and epilepsy. Two reviewers independently screened all titles and abstracts, carried out a risk of bias assessment and extracted the data. Meta‐analyses were carried out using random effects models. Of the 3640 abstracts and titles screened, we identified 10 eligible studies encompassing a total of 1 548 967 subjects. Few of the studies used validated case ascertainment tools and there were inconsistent attempts to control for confounding. There was an overall 52% increase in the prevalence of migraine among PWE versus those without epilepsy [PR: 1.52 (95% CI: 1.29, 1.79)]. There was an overall 79% increase in the prevalence of epilepsy among migraineurs versus those without migraine [PR: 1.79 (95% CI: 1.43, 2.25)]. Subgroup analyses revealed that the method of ascertaining the epilepsy or migraine status of subjects was an important source of inter‐study heterogeneity. Additional high quality primary studies are required, ones that use validated and accurate methods of case ascertainment as well as control for potential confounders.
Evaluating tradeoff between PDP and k-FDP algorithms under sharing reliable links

This paper evaluates tradeoff between the partial disjoint path (PDP) and the k failure-disjoint path (k-FDP) algorithms for finding k disjoint paths that share reliable links, which have no failures. Adopting a suitable algorithm for each network scenario is able to save time for network operators or save cost for network providers. We provide examined data under sharing reliable links scenario for implementing survivability of networks. The PDP algorithm finds k disjoint paths with sharing reliable links. The FDP algorithm finds disjoint paths with minimum summation of two disjoint path costs. The k-FDP algorithm is extended from the original FDP algorithm. However, k-FDP takes longer time to find the disjoint paths than PDP for same cases. In this paper, computational time and summation of path costs are considered as performance indicators. The performance of both algorithms is examined using computer simulations with various network topologies. The simulation results show that the k-FDP algorithm takes a large amount of computational time to find k disjoint paths when the number of nodes increases. The PDP algorithm is able to reduce the computational time to find k disjoint paths in the networks by 99% compared to the k-FDP algorithm. However, the summation of path costs of PDP is higher when the number of required disjoint paths increases. Our comparative results assist network operators or planners to understand the tradeoff between PDP and k-FDP which in turn helps them to make an appropriate decision in network implementations.
Producing juridical knowledge: “Rights of Nature” or the naturalization of rights?

Rights of Nature, the idea of extending legal personhood to nature, is today’s most prominent alternative to mainstream environmental governance. Proponents describe Rights of Nature as a grassroots movement of diverse actors opposing commodification of life and anthropocentric dualism of western thought. In Rights of Nature, indigenous cosmologies validate holistic models of life to overcome dualities of nature and humans. We argue this move enacts a paradoxical dichotomy between the West and the rest and, in so doing, treats rights as existing outside western history. In this article, we push against the image of Rights of Nature as a global consensus converging on the inevitability of rights. Applying decolonial, black feminist perspectives on historical mobilizations of rights, we ask how rights for nature becomes rights as natural. We trace individuals, institutions, and ideas associated with Rights of Nature, conceptualized as a Transnational Policy Network. We find tight linkages among a small number of actors, mostly from the global North, who draw on western holism and jurisprudence to present nature’s rights as an indigenous and natural alternative to western development. Rights of Nature is not just connected to the same ideas of nature and law it rejects, but through these connections Rights of Nature universalizes colonial modes of existence as natural.
Corneal Backscatters as an Objective Index for Assessing Fuchs' Endothelial Corneal Dystrophy: A Pilot Study

Purpose To provide an objective, quantitative approach for monitoring Fuchs' endothelial corneal dystrophy (FECD), with Scheimpflug imaging. Design This is a retrospective case-control pilot study. Methods The study group consisted of 53 eyes in 27 patients diagnosed with FECD, with normal subjects paired as control. Main outcome measures were corneal thickness, morphological patterns on densitograms, and indices of corneal density including the average area density (mean AD) and the average ratio of Descemet's membrane density versus area density (DM/AD) in Pentacam Scheimpflug images. Results There were no significant differences in age and corneal thickness between FECD and normal groups. Morphologically, hanging-hammock patterns were noted on the densitograms of FECD patients, which were different from the high-back chair patterns in normal subjects. Quantitatively, mean AD and DM/AD were both elevated in FECD patients as compared with normal subjects (P = 0.01 and 0.025, resp.). In addition, FECD patients with corneal edema had significantly higher mean AD (P = 0.018) than those without corneal edema. Conclusions This pilot study shows that Pentacam system provides an objective, quantitative way to approach FECD corneas. It can assist ophthalmologists in detecting the early change and in monitoring disease progression of FECD. Further studies are needed to consolidate the findings.
Assessment of Hemispheric Language Lateralization: A Comparison between fMRI and fTCD

The cerebral blood flow velocity (CBFV) in the basal arteries during a word-generation task was assessed by functional transcranial Doppler ultrasonography (fTCD) and by functional magnetic resonance imaging (fMRI). The study investigates how event-related CBFV modulations in the middle cerebral artery (MCA) relate to regional cerebral blood flow (rCBF) changes. Both fMRI and fTCD were used in 13 subjects (7 men, 6 women, aged 21 to 44 years). The maximum difference of relative CBFV changes between the left and right MCA during the word-generation task was used as the language laterality index (LIfTCD). For the fMRI examination during the nearly identical language task, the corresponding index was defined by LIfMRI = 100(NL − NR)/(NL + NR), where NL and NR refer to the numbers of voxels activated in the left and right hemisphere, respectively. The evoked CBFV changes expressed by LIfTCD and the corresponding laterality index, LIfMRI, estimated by fMRI showed a close linear relation (regression analysis: r = 0.95, p < 0.0001). The results of this study demonstrate that language-related velocity changes in the MCAs relate to rCBF increases in a linear fashion. Since the laterality indices assessed by fMRI and fTCD are in such close agreement both techniques can therefore be used in a complementary way.
Management of membranous nephropathy

SUMMARY: The Management of membranous nephropathy requires a recognition of its natural history and an ability to predict those pationts with the worst prognosis. Treatment of those at risk of progression with immunosuppressive drugs should be accompanied by additional conservative risk reduction strategies such as dietary protein restriction, blood pressure reduction, angiotensin‐converting enzyme inhibitors and lipid‐lowering agents. Anticoagulants should also be considered as well as medications to reduce drug toxicity.
Hip Muscle Strength Predicts Noncontact Anterior Cruciate Ligament Injury in Male and Female Athletes

Background: Prospective studies have reported that abnormal movement patterns at the trunk, hip, and knee are associated with noncontact anterior cruciate ligament (ACL) injuries. Impaired hip strength may underlie these abnormal movement patterns, suggesting that diminished hip strength may increase the risk of noncontact ACL injury. Purpose: To determine whether baseline hip strength predicts future noncontact ACL injury in athletes. Study Design: Case-control study; Level of evidence, 3. Methods: Before the start of the competitive season, isometric hip strength (external rotation and abduction) was measured bilaterally by use of a handheld dynamometer in 501 competitive athletes (138 female and 363 male athletes) participating in various sports. During the sport season, ACL injury status was recorded, and injured athletes were further classified based on the mechanism of injury (noncontact vs contact). After the season, logistic regression was used to determine whether baseline hip strength predicted future noncontact ACL injury. Receiver operating characteristic (ROC) curves were constructed independently for each strength measure to determine the clinical cutoff value between a high-risk and low-risk outcome. Results: A total of 15 noncontact ACL injuries were confirmed (6 females, 9 males), for an overall annual incidence of 3.0% (2.5% for males, 4.3% for females). Baseline hip strength measures (external rotation and abduction) were significantly lower in injured athletes compared with noninjured athletes (P = .003 and P < .001, respectively). Separate logistic regression models indicated that impaired hip strength increased future injury risk (external rotation: odds ratio [OR] = 1.23 [95% CI, 1.08-1.39], P = .001; abduction: OR = 1.12 [95% CI, 1.05-1.20], P = .001). Clinical cutoffs to define high risk were established as external rotation strength ≤20.3% BW (percentage of body weight) or abduction strength ≤35.4% BW. Conclusion: Measures of preseason isometric hip abduction and external rotation strength independently predicted future noncontact ACL injury status in competitive athletes. The study data suggest that screening procedures to assess ACL injury risk should include an assessment of isometric hip abduction and/or external rotation strength.