Miracle-dz/UniFAR-FTUs huggingface dataset:
High-Performance Work System, Work Well-Being, and Employee Creativity: Cross-Level Moderating Role of Transformational Leadership

Under the new normal, the economic development mode and growth momentum of China has brought about fundamental changes, which means that the development of enterprises has gradually shifted from being factor-and investment-driven to being innovation-and talent-driven. As the foundation of corporate innovation, employee creativity plays an important role in this process. In the field of strategic human resource management, high-performance work system is the embodiment of its core competence. Although some research has begun to try to explore the impact of high-performance work system on employee creativity, the underlying mechanism and the boundary condition is not yet fully understood. According to the Job demands-resources (JD-R) model, this study theorized and examined whether and when high-performance work system stimulate employee creativity. Using a sample of large and medium-sized enterprises in China, we collected data, which are time-lagged and multilevel, from 266 employees in 61 departments. Results of the hierarchical linear model found that (1) High-performance work system is positively related to employee creativity; (2) High-performance work system positively affects employee work well-being; (3) Work well-being positively affects employee creativity; (4) Employee work well-being partially mediates the relationship between high-performance work system and creativity; (5) Transformational leadership, which represents an important contextual variable in the workplace, moderates the relationship between work well-being and employee creativity; (6) Moreover, we have also revealed that transformational leadership can moderate the indirect effect of high-performance work system on employee creativity. We discussed the theoretical and practical implications of these findings.
Variations in Archaeal and Bacterial Diversity Associated with the Sulfate-Methane Transition Zone in Continental Margin Sediments (Santa Barbara Basin, California)

ABSTRACT The sulfate-methane transition zone (SMTZ) is a widespread feature of continental margins, representing a diffusion-controlled interface where there is enhanced microbial activity. SMTZ microbial activity is commonly associated with the anaerobic oxidation of methane (AOM), which is carried out by syntrophic associations between sulfate-reducing bacteria and methane-oxidizing archaea. While our understanding of the microorganisms catalyzing AOM has advanced, the diversity and ecological role of the greater microbial assemblage associated with the SMTZ have not been well characterized. In this study, the microbial diversity above, within, and beneath the Santa Barbara Basin SMTZ was described. ANME-1-related archaeal phylotypes appear to be the primary methane oxidizers in the Santa Barbara Basin SMTZ, which was independently supported by exclusive recovery of related methyl coenzyme M reductase genes (mcrA). Sulfate-reducing Deltaproteobacteria phylotypes affiliated with the Desulfobacterales and Desulfosarcina-Desulfococcus clades were also enriched in the SMTZ, as confirmed by analysis of dissimilatory sulfite reductase (dsr) gene diversity. Statistical methods demonstrated that there was a close relationship between the microbial assemblages recovered from the two horizons associated with the geochemically defined SMTZ, which could be distinguished from microbial diversity recovered from the sulfate-replete overlying horizons and methane-rich sediment beneath the transition zone. Comparison of the Santa Barbara Basin SMTZ microbial assemblage to microbial assemblages of methane seeps and other organic matter-rich sedimentary environments suggests that bacterial groups not typically associated with AOM, such as Planctomycetes and candidate division JS1, are additionally enriched within the SMTZ and may represent a common bacterial signature of many SMTZ environments worldwide.
Middle Managers’ Experiences and Role in Implementing an Interactive Tailored Patient Assessment eHealth Intervention in Clinical Practice

The role of nurse and physician managers is considered crucial for implementing eHealth interventions in clinical practice, but few studies have explored this. The aim of the current study was to examine the perceptions of nurse and physician managers regarding facilitators, barriers, management role, responsibility, and action taken in the implementation of an eHealth intervention called Choice into clinical practice. Individual qualitative interviews were conducted with six nurses and three physicians in management positions at five hospital units. The findings revealed that nurse managers reported conscientiously supporting the implementation, but workloads prevented them from participating in the process as closely as they wanted. Physician managers reported less contribution. The implementation process was influenced by facilitating factors such as perceptions of benefits from Choice and use of implementation strategies, along with barriers such as physician resistance, contextual factors and difficulties for front-line providers in learning a new way of communicating with the patients. The findings suggest that role descriptions for both nurse and physician managers should include implementation knowledge and implementation skills. Managers could benefit from an implementation toolkit. Implementation management should be included in management education for healthcare managers to prepare them for the constant need for implementation and improvement in clinical practice.
GOMOS ozone profile validation using ground-based and balloon sonde measurements

The validation of ozone profiles retrieved by satellite instruments through comparison with data from ground-based instruments is important to monitor the evolution of the satellite instrument, to assist algorithm development and to allow multi-mission trend analyses. In this study we compare ozone profiles derived from GOMOS night-time observations with measurements from lidar, microwave radiometer and balloon sonde. Collocated pairs are analysed for dependence on several geophysical and instrument observational parameters. Validation results are presented for the operational ESA level 2 data (GOMOS version 5.00) obtained during nearly seven years of observations and a comparison using a smaller dataset from the previous processor (version 4.02) is also included. The profiles obtained from dark limb measurements (solar zenith angle >107°) when the provided processing flag is properly considered match the ground-based measurements within ±2 percent over the altitude range 20 to 40 km. Outside this range, the pairs start to deviate more and there is a latitudinal dependence: in the polar region where there is a higher amount of straylight contamination, differences start to occur lower in the mesosphere than in the tropics, whereas for the lower part of the stratosphere the opposite happens: the profiles in the tropics reach less far down as the signal reduces faster because of the higher altitude at which the maximum ozone concentration is found compared to the mid and polar latitudes. Also the bias is shifting from mostly negative in the polar region to more positive in the tropics Profiles measured under "twilight" conditions are often matching the ground-based measurements very well, but care has to be taken in all cases when dealing with "straylight" contaminated profiles. For the selection criteria applied here (data within 800 km, 3 degrees in equivalent latitude, 20 h (5 h above 50 km) and a relative ozone error in the GOMOS data of 20% or less), no dependence was found on stellar magnitude, star temperature, nor the azimuth angle of the line of sight. No evidence of a temporal trend was seen either in the bias or frequency of outliers, but a comparison applying less strict data selection criteria might show differently.
Auxilin is required for formation of Golgi-derived clathrin-coated vesicles during Drosophila spermatogenesis

Clathrin has previously been implicated in Drosophila male fertility and spermatid individualization. To understand further the role of membrane transport in this process, we analyzed the phenotypes of mutations in Drosophila auxilin (aux), a regulator of clathrin function, in spermatogenesis. Like partial loss-of-function Clathrin heavy chain (Chc) mutants, aux mutant males are sterile and produce no mature sperm. The reproductive defects of aux males were rescued by male germ cell-specific expression of aux, indicating that auxilin function is required autonomously in the germ cells. Furthermore, this rescue depends on both the clathrin-binding and J domains, suggesting that the ability of Aux to bind clathrin and the Hsc70 ATPase is essential for sperm formation. aux mutant spermatids show a deficit in formation of the plasma membrane during elongation, which probably disrupts the subsequent coordinated migration of investment cones during individualization. In wild-type germ cells, GFP-tagged clathrin localized to clusters of vesicular structures near the Golgi. These structures also contained the Golgi-associated clathrin adaptor AP-1, suggesting that they were Golgi-derived. By contrast, in aux mutant cells, clathrin localized to abnormal patches surrounding the Golgi and its colocalization with AP-1 was disrupted. Based on these results, we propose that Golgi-derived clathrin-positive vesicles are normally required for sustaining the plasma membrane increase necessary for spermatid differentiation. Our data suggest that Aux participates in forming these Golgi-derived clathrin-positive vesicles and that Aux, therefore, has a role in the secretory pathway.
Physiological and Behavioural Responses of Cattle to High and Low Space, Feed and Water Allowances During Long Distance Transport in the South of Chile

Simple Summary Regarding the topography of Chile, livestock have to travel for long distances (1240 km), including road and sea transport. During this journey food and water deprivation, overstocking and handling issues have been reported as common problems. The lack of adequate conditions onboard can produce adverse consequences for the welfare of livestock in transit. In the current study the physiological and behavioural implications of two different space allowances and the lack of food and water during the long-distance transport has been studied. The current space provided in Chile to the cattle onboard (1 m2/500 kg) appears to be detrimental to their welfare. Lack of room to allow postural adjustment in combination with limited access to food and water resulted in poor nutrition and dehydration. Behavioural responses to the low space were also affected. Cattle increased the time spend eating and ruminating when 30% extra space and more feed was provided. We conclude that, under the current Chilean standards for the long-distance transport, the welfare of the livestock is adversely affected. This research can provide valuable information for the reform of welfare standards for the transport of livestock in Chile. Abstract Long distance transport of livestock from Patagonia to central Chile involves both road and sea transport and has a potential impact on the welfare of animals. Fifty Bos taurus cattle of approximate age six months were exposed to a journey of four days, with both the sea and road components undertaken in a truck (roll-off roll-on system) with two pens of different dimensions. Thirty-two and eighteen cattle were randomly allocated to two treatment groups: Low and High welfare standards, which were provided 0.66 m2/head and 0.86 m2/head, respectively, and a fixed amount of feed and water daily to each pen, 1.25 kg hay/head and 3.1 L water/head in the Low welfare treatment and 2.22 kg/head and 5.6 L/head in the High welfare treatment, respectively. Low welfare animals had increased plasma total protein and albumin, which is suggested to be due to limited water availability, and also haptoglobin, suggesting inflammatory responses. Cattle in the High welfare treatment spent more time eating and ruminating than those in the Low space allowance, but they had increased cortisol at the end of the journey, perhaps reflecting increased fighting with more space. Cattle welfare in both treatments was adversely affected by the limited feed and water supplies, with increased beta-hydroxybutyrate at the end of the voyage; total protein was increased in just the low welfare standard group where low space allowance and less food and water was provided. Creatine phosphokinase also increased after the journey, compared with before, indicating bruising. Limiting feed and water availability to cattle in the low welfare treatment resulted in physiological evidence of undernutrition and low hydration status, but it also reduced the stress response, probably because there was less fighting.
Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases

The aim of this study was to assess the effect of leucine supplementation on elements of the ubiquitin–proteasome system (UPS) in rat skeletal muscle during immobilization. This effect was evaluated by submitting the animals to a leucine supplementation protocol during hindlimb immobilization, after which different parameters were determined, including: muscle mass; cross‐sectional area (CSA); gene expression of E3 ligases/deubiquitinating enzymes; content of ubiquitinated proteins; and rate of protein synthesis. Our results show that leucine supplementation attenuates soleus muscle mass loss driven by immobilization. In addition, the marked decrease in the CSA in soleus muscle type I fibers, but not type II fibers, induced by immobilization was minimized by leucine feeding. Interestingly, leucine supplementation severely minimized the early transient increase in E3 ligase [muscle ring finger 1 (MuRF1) and muscle atrophy F‐box (MAFbx)/atrogin‐1] gene expression observed during immobilization. The reduced peak of E3 ligase gene expression was paralleled by a decreased content of ubiquitinated proteins during leucine feeding. The protein synthesis rate decreased by immobilization and was not affected by leucine supplementation. Our results strongly suggest that leucine supplementation attenuates muscle wasting induced by immobilization via minimizing gene expression of E3 ligases, which consequently could downregulate UPS‐driven protein degradation. It is notable that leucine supplementation does not restore decreased protein synthesis driven by immobilization. Muscle Nerve, 2010
Relationship between efficacy of sunitinib and KIT mutation of patients with advanced gastrointestinal stromal tumors after failure of imatinib

Background: A large number of studies have shown that KIT mutations are closely related to the prognosis of gastrointestinal stromal tumors (GISTs). At the same time, sunitinib (SU) has become the second-line recommended drug for GISTs because of its efficacy. We initiated a systematic review to compare the efficacy of SU after failure of Imatinib (IM) in different KIT mutations. Methods: We searched for SU-treated patients with advanced GISTs after failed IM treatment by using databases such as PubMed, EMBASE, and the Cochrane Library, up to March 2018. We conducted statistical analyses to calculate the odds ratio (OR), hazard ratio (HR), and 95% confidence interval (CI) using fixed-effects and random-effects models by Review Manager 5.3 software. Results: We included a total of 474 patients from 3 retrospective studies and 2 cohort studies. Patients with exon 9 mutations had higher clinical benefit (OR = 2.61, 95% CIs = 1.32–5.18, P = .006) rates and longer progression-free survival (progressive disease, HR = 0.51, 95% CIs = 0.36–0.72, P = .0001) compared with exon 11, but there was no statistically significant difference in overall survival (OS, HR = 0.93, 95% CIs = 0.34–2.55, P = .89) and there was greater heterogeneity (Tau2 = 0.72, Chi2 = 21.45, df = 3, P < .001, I2 = 86%). Subgroup analysis suggests that race may be one of the sources of heterogeneity. Conclusion: The results show that efficacy of SU is closely associated with KIT genotypes in GISTs. Moreover, racial factor also directly affects the prognosis of different KIT mutational status, so GISTs patients of different genotypes might also consider the use of targeted drugs in consideration of ethnic differences.
Comparison of Two Generations of ActiGraph Accelerometers: The CARDIA Study

PurposeThis study aimed to examine the comparability of the ActiGraph 7164 and wGT3X-BT wear time, count-based estimates, and average time per day in physical activity of different intensities. MethodsWe studied 87 Coronary Artery Risk Development in Young Adults (CARDIA) participants 48–60 yr of age who simultaneously wore the 7164 and wGT3X-BT accelerometers at the waist in 2015–2016, with wear time of ≥4 of 7 d, ≥10 h·d−1 for both monitors. Freedson cutpoints (counts per minute) were used to define sedentary (<100), light (100–1951), moderate (1952–5724), and vigorous activity (≥5725). Agreement was evaluated using paired-difference tests, intraclass correlation coefficients, and Bland–Altman plots. Given systematic differences in count-based estimates between monitors, a calibration formula applied to the wGT3X-BT values was obtained by linear regression. ResultsTotal detected wear time minutes per day was nearly identical between the 7164 and the wGT3X-BT (881.5 ± 70.9 vs 880.3 ± 78.1, P = 0.72). The wGT3X-BT values were calibrated to the 7164 values by dividing counts by 1.088. After calibration, no differences were observed between the 7164 and the wGT3X-BT in total counts per day (310,184 ± 129,189 vs 307,085 ± 135,362, P = 0.48), average counts per min per day (349.5 ± 139.5 vs 346.5 ± 147.2, P = 0.54), sedentary (513.2 ± 93.6 vs 509.6 ± 98.6, P = 0.23), light (335.3 ± 81.5 vs 338.7 ± 81.1, P = 0.22), moderate (31.0 ± 21.9 vs 30.3 ± 23.4, P = 0.31), or moderate-to-vigorous minutes per day (33.1 ± 24.6 vs 32.0 ± 26.0, P = 0.13). A significant difference was observed for vigorous minutes per day (0.2 ± 1.0 vs 0.0 ± 0.3, P < 0.01); however, the absolute difference was marginal. Intraclass correlation coefficients showed excellent agreement for all measures (0.95–0.99). ConclusionsAfter applying a calibration formula, the 7164 and wGT3X-BT were comparable for total wear time, count-based estimates, and average minutes per day in sedentary, light, moderate, and moderate-to-vigorous activity. Findings illustrate a novel methodological approach to facilitate accelerometer data harmonization.
Hypereosinophilic syndrome and mepolizumab.

One safety concern for mepolizumab’s use, beyond a clinical trial, is the importance of excluding occult parasitic infections, most importantly Strongyloides stercoralis. Suppression of eosinophilia with corticosteroids causes life-threatening strongyloides hyperinfection (1). Whether anti-interleukin-5 therapy holds this same iatrogenic mortality risk is unknown, but probable. One in 8 Americans are foreign-born and >50–75% of immigrants with asymptomatic eosinophilia will have a parasitic infection (2). Seybolt et al. found 12% of arriving refugees had eosinophilia, and although 71% had negative stool ova and parasite examinations, 39% and 22% had serologic evidence of strongyloidiasis and schistosomiasis, respectively, when tested (2). In Sudanese refugees, rates were 46% and 44% (3). We have reported that practicing U.S. physicians and physicians-in-training have poor knowledge of strongyloidiasis which places immigrants at iatrogenic risk (4). Since standard stool examination is notoriously insensitive (≤50%) for detecting strongyloides, serologic screening or presumptive treatment is often necessary (4,5). Before therapy for hypereosinophilia, all persons with previous exposure must be tested for parasites commonly causing chronic infections and eosinophilia such as strongyloidiasis, schistosomiasis, and filariasis.
A Novel Sparse Representation Classification Method for Gas Identification Using Self-Adapted Temperature Modulated Gas Sensors

A novel sparse representation classification method (SRC), namly SRC based on Method of Optimal Directions (SRC_MOD), is proposed for electronic nose system in this paper. By finding both a synthesis dictionary and a corresponding coefficient vector, the i-th class training samples are approximated as a linear combination of a few of the dictionary atoms. The optimal solutions of the synthesis dictionary and coefficient vector are found by MOD. Finally, testing samples are identified by evaluating which class causes the least reconstruction error. The proposed algorithm is evaluated on the analysis of hydrogen, methane, carbon monoxide, and benzene at self-adapted modulated operating temperature. Experimental results show that the proposed method is quite efficient and computationally inexpensive to obtain excellent identification for the target gases.
Comparative effectiveness of first-line antiretroviral therapy: results from a large real-world cohort after the implementation of Dolutegravir.

OBJECTIVE We aimed to assess the effectiveness of first-line antiretroviral therapy (ART) regimens in achieving viral suppression at 12 months, from 2014 to 2017 in Brazil. DESIGN Retrospective cohort study utilizing programmatic data from the Brazilian HIV Program. METHODS Adults (aged 15-80 years) who started ART from January/2014 to July/2017 and had a viral load 365 (±90) days after treatment initiation were included. Associations with achieving viral suppression (<50 copies/mL) at 365 (±90) days were assessed using logistic regression. Our main study variable was ART regimen, and covariates included year of ART initiation, sex/exposure group, age, education, race, region, baseline CD4 and viral load counts, and adherence measured by pharmacy refill data. We performed both intent-to-treat and per-protocol-analogous analyses. RESULTS Of 107,647 ART-naïve patients, 71.5% initiated with tenofovir/lamivudine/efavirenz (TLE) and 10.5% with tenofovir/lamivudine/dolutegravir (TLD). Median age and CD4 counts were 34 (IQR 26-46) and 379 cells/mm (IQR 190-568), respectively; 68.0% were males. Viral suppression by 12 months was 84.0% (95%CI 83.7%-84.2%) with TLE and 90.5% (95%CI 90.0%-91.0%) with TLD, and below 80% for protease-inhibitor-based-regimens. In the multivariable intent-to-treat-analogous analysis, controlling for cofactors related to viral suppression including adherence, the adjusted odds ratio (aOR) for TLD's viral suppression relative to TLE was 1.56 (95%CI 1.40-1.75). Findings were robust to secondary per-protocol-analogous and sensitivity analysis. CONCLUSION Our results showed the superiority of dolutegravir- over efavirenz- and protease-inhibitor- based regimens in suppressing viral replication in a real-word cohort of HIV-positive adults. This superiority was not driven by higher levels of adherence with dolutegravir-based regimens.