Miracle-dz/UniFAR-FTUs huggingface dataset:
Standardized Mortality Ratio in Patients with Schizophrenia — Findings from Thirthahalli: A Rural South Indian Community

Background: Schizophrenia is associated with excess mortality experience than the general population. Though this is one of the important outcome measures, it has not been adequately explored especially in rural community dwelling patients in India. We describe the standardized mortality ratio (SMR) of a cohort of schizophrenia patients of Thirthahalli, one such rural taluk of South India. Materials and Methods: SMRs for the years 2009-2011 were calculated. A number of patients in the cohort were 301, 317, and 325 for those consecutive years, respectively. Observed deaths among the patients were noted for these years separately. Crude death rates (CDRs) of the general population of Shimoga district were obtained from the Statistics Department of the Government of Karnataka. CDR (per 1000) was multiplied by the number of patients in each year to get the expected deaths. Then, observed deaths were divided by the expected deaths to get the SMR. Results: There were totally 12 deaths among the patients in these 3 years. SMRs for the years 2009, 2010, and 2011 were respectively 1.4, 1.8, and 2.2. Six had died out of natural (medical) causes. Four had committed suicide, and one died from an accident. Cause from one death remained unknown. There was no statistically significant difference between the alive and deceased patients in any of the demographic or clinical variables. Conclusions: Mortality among schizophrenia patients in this rural cohort is considerably lower than patients from developed countries. Nevertheless, nearly two-fold excess mortality in schizophrenia calls for attention to their medical and psychosocial needs.
The Effect of Carpal Tunnel Release on Neuropathic Pain in Carpal Tunnel Syndrome

Purpose The aim of this study was to determine the risk factors of neuropathic pain (NP) in the patient with carpal tunnel syndrome (CTS) before and after the carpal tunnel release. Materials and Methods One hundred and two CTS patients were enrolled in the study. The pain score was measured by the visual analogue score. NP was determined by the painDETECT (PD) questionnaire. All subjects were divided into 3 groups at 12 weeks after surgery: an Improved, Unchanged, and Worsened group. The risk factors of worsening NP after surgery were evaluated. Results We found that 36% and 18% of patients with CTS had neuropathic pain before and 12 weeks after surgery, respectively, and pain was significantly stronger than in those without NP. The PD score of eight hands worsened after surgery. In the “Improved group,” the average age at the surgery was younger and the pain score was lower than in the “Unchanged group. ” Conclusions. The surgery was very effective on NP of CTS; however, the PD in 7% of hands worsened after surgery. Risk factors before surgery that predicted worse NP after surgery were found to be a younger age, weaker pain, and the absence of night pain.
Error control of the vectorial nondirective stable plane wave multilevel fast multipole algorithm

Novel formulas are presented that allow the rapid estimation of the number of terms L that needs to be taken into account in the translation operator of the vectorial Nondirective Stable Plane Wave Multilevel Fast Multipole Algorithm (NSPWMLFMA). This is especially important for low frequencies, since the L needed for error- controllability can be substantially higher than the L required in the scalar case. Although these formulas were originally derived for use in the NSPWMLFMA, they are equally useful in at least three other fast matrix multiplication methods.
Precision Medicine Concepts in T-Cell Lymphoma

Modern oncology witnesses an increasing number of new effective anticancer drugs targeting specific oncogenic pathways. Despite these advances, real-world experience with targeted single agents is disappointing since drug resistance usually occurs after a short time. This is particularly true for patients with refractory or relapsed T-cell lymphoma (TCL) who so far could not benefit from novel agents and demonstrate a short survival time of only 3 months. The novel genetic information gained from genome-wide high-throughput techniques has greatly improved our understanding of TCL. However, if precision medicine strategies are based solely on genetics, it runs into two major challenges: (1) the heterogeneity within the cancer of an individual patient and (2) the incomplete understanding of the degree of con-tribution of a specific mutation to a tumor phenotype. Next-generation functional drug screening (ngFDS) aims to address these problems. Studies that proof the clinical utility of ngFDS are currently limited. The following chapter aims to discuss recent advances of ngFDS and to line out its potential for TCL patients. non-randomized and therapies. of
Exploring the effects of inclusion of dietary fresh Azolla on the performance of White Pekin broiler ducks

Aim: The objective of this study was to investigate the dietary advantages of inclusion of unconventional nutrient source, i.e., Azolla in the basal diet of White Pekin broilers. Materials and Methods: All ducklings were randomly distributed into three treatment groups with three replicates each and each replicate having 12 ducklings and were reared in deep litter system. Groups were subjected to three dietary treatments such as G1: Basal diet, G2: Basal diet + 5% fresh Azolla of basal diet, G3: Basal diet + 10% fresh Azolla of basal diet. During experimental period, parameters, such as bodyweight, bodyweight gain, feed consumption,feed conversion ratio(FCR), and economic of production,wererecorded. Results: The result showed that body weights in every week, except the 5th week, did not differ significantly between groups. However, no significant difference was observed between the groups in any week in terms of absolute body weight gain and feed consumption. As regard to FCR, the 10% Azolla group (G3) showed the best feed efficiency followed by the 5% Azolla group (G2) and the control group (G1). On the basis of profit/bird or profit/kg live weight, each of the Azolla-fed group showed a higher economic efficiency than the control. Conclusion: From the experiment, it was concluded that Azollaat 5 or 10% level can be included in the diet to economize the White Pekin broiler farming, and it can be great impetus to poultry farming to include unconventional nutrient source as a dietary supplement.
Overview of TASS 2017 Resumen de TASS 2017

This paper describes TASS 2017, the sixth edition of the Workshop on Semantic Analysis at SEPLN 2017. The main aim is to encourage the research and development of new resources, algorithms and techniques for different tasks of semantic analysis in Spanish. In this paper, we present the proposed tasks, the generated datasets, and a summary of the submitted systems.
Pretreatment blood–brain barrier disruption and post-endovascular intracranial hemorrhage

Objective: This study sought to confirm the relationship between the degree of blood–brain barrier (BBB) damage and the severity of intracranial hemorrhage (ICH) in a population of patients who received endovascular therapy. Methods: The degree of BBB disruption on pretreatment MRI scans was analyzed, blinded to follow-up data, in the DEFUSE 2 cohort in which patients had endovascular therapy within 12 hours of stroke onset. BBB disruption was compared with ICH grade previously established by the DEFUSE 2 core lab. A prespecified threshold for predicting parenchymal hematoma (PH) was tested. Results: Of the 108 patients in the DEFUSE 2 trial, 100 had adequate imaging and outcome data and were included in this study; 24 developed PH. Increasing amounts of BBB disruption on pretreatment MRIs was associated with increasing severity of ICH grade (p = 0.004). BBB disruption on the pretreatment scan was associated with PH (p = 0.020) with an odds ratio for developing PH of 1.69 for each 10% increase in BBB disruption (95% confidence interval 1.09–2.64), although a reliably predictive threshold was not identified. Conclusions: The amount of BBB disruption on pretreatment MRI is associated with the severity of ICH after acute intervention. This relationship has now been identified in patients receiving IV, endovascular, and combined therapies. Further study is needed to determine its role in guiding treatment.
A real-time database architecture for motion capture data

Due to the popularity of motion capture data in many applications, such as games, movies and virtual environments, huge collections of motion capture data are now available. It is becoming important to store these data in compressed form while being able to retrieve them without much overhead. However, there is little work that addresses both issues together. In this paper, we address these two issues by proposing a novel database architecture. First, we propose a lossless compression algorithm to compress the motion clips, which is based on a novel Alpha Parallelogram Predictor (APP) to estimate the degree of freedom (DOF) of each child joint from its immediate neighbors and parents that have already been processed. Second, we propose to store selected eigenvalues and eigenvectors of each motion clip, which only require a very small amount of memory overheads, for faster filtering of irrelevant motions. Based on this architecture, real-time queries become a three-step process. In the first two steps, we perform a quick filtering to identify relevant motion clips in the database through a two-level indexing structure. In the third step, only a small number of candidate clips are uncompressed and accurately matched with a Dynamic Time Warping algorithm. Our results show that users can efficiently search clips from this losslessly compressed motion database.
VeilMe: An Interactive Visualization Tool for Privacy Configuration of Using Personality Traits

With the recent advances in using data analytics to automatically infer one's personality traits from their social media data, users are facing a growing tension between the use of the technology to aid self development in workplace and the privacy concerns of such use. Given the richness of personality data that can be derived today and the varied sensitivity of revealing such data, it is a non-trivial task for users to configure their privacy settings for sharing and protecting their derived personality data. Here we present the design, development, and evaluation of an interactive visualization tool, VeilMe, which helps users configure the privacy settings for the use of their personality portraits derived from social media. Unlike other privacy configuration tools, our tool offers two distinct advantages. First, it presents a novel and intuitive visual interface that aids users in understanding and exploring their own personality traits derived from their social media data, and configuring their privacy preferences. Second, our tool helps users to jump start their privacy settings by suggesting initial sharing strategies based on a set of factors, including the users' personality and target audience. We have evaluated the use of our tool with 124 participants in an enterprise context. Our results show that VeilMe effectively supports various user privacy configuration tasks, and also suggest several design implications, including the approaches to personalized privacy configurations.
In vivo T cell tumor therapy with monoclonal antibody directed to the V beta chain of T cell antigen receptor

To test whether antibodies directed to TCR affect T cell tumor growth in vivo, mice were inoculated intravenously with C6VL tumor cells expressing V beta 6 TCR and then treated intraperitoneally with mAb specific for V beta 6 TCR. Administration of anti-V beta 6 antibody prolonged survival of mice bearing V beta 6-expressing tumor cells and it led to the induction of host immunity to the tumor cells in surviving animals. This treatment eliminated not only tumor cells bearing V beta 6 TCR but also normal host T cells expressing V beta 6 T cells receptors. However, the lack of V beta 6-expressing T cells in such treated mice did not result in generalized immune disfunction. These data demonstrate the utility of anti-TCR V segment antibody in the treatment of T cell tumors. Most importantly, since the number of V genes for the T cell antigen receptor is limited, both in man and in mouse, it should be possible to establish a panel of mAbs directed to each V gene product and use such antibodies in the treatment of T cell neoplasms.
Upstream analyses create problems with DNA-based species delimitation.

MELISA OLAVE1, EDUARD SOLA2, AND L. LACEY KNOWLES3 1Centro Nacional Patagonico – Consejo Nacional de Investigaciones Cientificas y Tecnicas (CENPAT-CONICET), Puerto Madryn, Chubut U 9120 ACD, Argentina, 2Department de Genetica, Facultat de Biologia and Institut de Recerca de la Biodiversitat (IRBio), Universitat de Barcelona, Av. Diagonal, 643, 08028, Barcelona, Catalonia, Spain and 3Department of Ecology and Evolutionary Biology, The University of Michigan, Ann Arbor, MI 41809-1029, USA ∗Correspondence to be sent to: Department of Ecology and Evolutionary Biology, The University of Michigan, Ann Arbor, MI 41809-1029, USA; E-mail: knowlesl@umich.edu.
Enzyme Relational Network Reveals Target Enzymes within Metabolic Submodules

Identification of enzyme targets for metabolic engineering requires a global view of the functional relationship among enzymes within metabolic network. In this paper, we propose a method to construct an enzyme relational network based on the significant effect of the rate change of one reaction on the rate of another reaction. We illustrate the method by using a kinetic model to formulate the enzyme relational network of the sucrose-to-starch conversion process. The network obtained shows two separate submodules, one of which possesses the enzymes located in cytosol; the other, in amyloplast. The network reveals that ADP-glucose pyrophosphorylase and inorganic pyrophosphatase are potential target enzymes for metabolic engineering to improve starch yield.
Magnetic resonance imaging tracking and assessing repair function of the bone marrow mesenchymal stem cells transplantation in a rat model of spinal cord injury

The transplantation of bone marrow mesenchymal stem cells (BMSCs) to repair spinal cord injury (SCI) has become a promising therapy. However, there is still a lack of visual evidence directly implicating the transplanted cells as the source of the improvement of spinal cord function. In this study, BMSCs were labeled with NF-200 promoter and lipase-activated gadolinium-containing nanoparticles (Gd-DTPA-FA). Double labeled BMSCs were implanted into spinal cord transaction injury in rat models in situ, the function recovery was evaluated on 1st, 7th, 14th, 28 th days by MRI, Diffusion Tensor Imaing, CT imaging and post-processing, and histological observations. BBB scores were used for assessing function recovery. After transplantation of BMSCs, the hypersignal emerged in spinal cord in T1WI starting at day 7 that was focused at the injection site, which then increased and extended until day 14. Subsequently, the increased signal intensity area rapidly spread from the injection site to entire injured segment lasting four weeks. The diffusion tensor tractography and histological analysis both showed the nerve fibre from dividing to connecting partly. Immunofluorescence showed higher expression of NF-200 in Repaired group than Injury group. Electron microscopy showed detachment and loose of myelin lamellar getting better in Repaired group compared with the Injury group. BBB scores in Repaired group were significantly higher than those of injury animals. Our study suggests that the migration and distribution of Gd-DTPA-FA labeled BMSCs can be tracked using MRI. Transplantation of BMSCs represents a promising potential strategy for the repair of SCI.
Vehicle detection and tracking at intersections by fusing multiple camera views

Intersections are challenging locations for drivers. Complex situations are common due to the variety of road users and intersection layouts. This contribution describes a real time method for detecting and tracking vehicles at intersections using images captured by a static camera network. After background subtraction, the foreground segments are projected on a common fusion map. Using this fusion map, the pose, width, and height of the vehicles can be determined. After that, the detected objects are tracked by a Gaussian-Mixture approximation of the Probability Hypothesis Density filter. Results of the intersection perception can further be communicated to equipped vehicles by wireless communication.
An improvement technique for the test compression ratio and application time of multiple expansion scan chain based SoC using new cost function

The importance of an efficient methodology for testing defects generated during IC manufacturing process is more than ever significant as the complexity of system on a chip (SoC) increases. Scan test is the most prevalent method for detecting stuck-at faults of digital integrated circuits. There are great demands for more efficient and lossless improvement techniques to reduce test cost growth caused by increase in chip density. In this paper, we propose a new multiple expansion scan chain (MESC) based technique by exploiting novel cost function considering additional variables for the total chain length of concatenated chains and sophisticated dependency analysis between each pair of chains. This proposed method is applied to two digital IP blocks of state-of-the-art mobile SoC fabricated in 14nm CMOS process. Experimental results show that the test data volume (TDV) is reduced by 10.4% and the longest chain length (LCL) decreases by 47.1% in maximum respectively when compared to existing works.
Chromosomal imbalances detected by array comparative genomic hybridization in human oligodendrogliomas and mixed oligoastrocytomas

Loss of heterozygosity and fluorescence in situ hybridization (FISH) studies have shown that deletions of 1p and 19q are highly prevalent in oligodendroglioma. However, these tumors have not been comprehensively screened for other alterations in chromosomal dosage. In this study, we used array‐based comparative genomic hybridization (CGHa) of mapped BAC DNA to screen for such alterations in 31 oligodendrogliomas (20 grade II, 9 grade III, and 2 grade IV) and 4 mixed oligoastrocytomas (1 grade I, 1 grade II, and 2 grade IV). The most frequent aberrations were loss of 1p (17 cases; 49%) and 19q (15 cases; 43%) and combined loss of 1p/19q (13 cases; 37%). In addition, deletion of 4q, 5p, 9p, 10q, 11p, and 13q was observed in 10, 4, 8, 4, 4, and 13 cases, respectively; loss of whole chromosomes 4, 9, and 13 in 4, 1, and 7 cases, respectively; gain of 7p, 8q, 10p, and 11q in 6, 6, 5, and 10 cases, respectively, and gain of whole chromosomes 7 and 11 in 2 patients each. Minimally altered regions detected by CGHa involved chromosome bands 1p36.32, 4q33, 5p15, 8q24, 11p15, and 19q13.3. Univariate analysis of all 35 cases suggested that combined deletion of 1p and 19q is associated with better survival (P = 0.03). In addition, 8q gain in the oligodendrogliomas was strongly associated with poor outcome (P = 0.002). Also associated with poor disease outcome were alterations that had low prevalence in the pure oligodendrogliomas, including loss of 3q, 9q, and 12q and gain of 1p, 8p, and 10q. In summary, in oligodendrogliomas, CGHa was able to detect novel small alterations in chromosomal dosage that had not been previously detected by other methods. In addition, our findings support the hypotheses that oligodendroglioma can be classified into several groups by CGHa analysis and that specific alterations in genetic dosage may have biologic or clinical significance. © 2004 Wiley‐Liss, Inc.
Basing Obfuscation on Simple Tamper-Proof Hardware Assumptions

Code obfuscation is one of the most powerful concepts in cryptography. It could yield functional encryption, digital rights management, and maybe even secure cloud computing. However, general code obfuscation has been proven impossible and the research then focused on obfuscating very specific functions, studying weaker security definitions for obfuscation, and using tamper-proof hardware tokens to achieve general code obfuscation. Following this last line this work presents the first scheme which bases general code obfuscation of multiple programs on one single stateless hardware token. Our construction is proven secure in the UC-framework and proceeds in three steps: 1. We construct an obfuscation scheme based on fully homomorphic encryption (FHE) and a hybrid functionality conditional decrypt, which decrypts the result of a homomorphic computation given a proof that the computation was performed as intended. One difficulty of the first step are possible decryptions errors in the FHE. These decryption errors can occur whenever the randomness for the encryption is chosen maliciously by the receiver of the obfuscated code. Such decryption errors then could make a real obfuscated computation distinguishable from a black box use of the non-obfuscated program. 2. Given two common reference strings (CRS) we construct a UC-protocol realizing the functionality conditional decrypt with a stateless hardware token. As the token is stateless it is resettable by a dishonest receiver and the proofs given to the token must be resettably sound. One additional difficulty occurs when the issuer of the token can be corrupted. A malicious token can be stateful and it cannot be prevented that it aborts after a hardwired number of invocations. To prevent adaptive behavior of a malicious token the data of the receiver has to be hidden from the token and the proofs given to the token must even hide the size of the program and the length of the computation. 3. Last we construct a protocol constructing a CRS with a stateless hardware token. Care has to be taken here to not let the token learn anything about the resulting CRS which could not be simulated, because the very same token will later be used in a protocol based on the security of this CRS.
A statistical model of the aberration structure of normal, well‐corrected eyes

Abstract A statistical model of the wavefront aberration function of the normal, well‐corrected eye was constructed based on normative data from 200 eyes which show that, apart from spherical aberration, the higher‐order aberrations of the human eye tend to be randomly distributed about a mean value of zero. The vector of Zernike aberration coefficients describing the aberration function for any individual eye was modelled as a multivariate, Gaussian, random variable with known mean, variance and covariance. The model was verified by analysing the statistical properties of 1000 virtual eyes generated by the model. Potential applications of the model include computer simulation of individual variation in aberration structure, retinal image quality, visual performance, benefit of novel designs of ophthalmic lenses, or outcome of refractive surgery.