Miracle-dz/UniFAR-FTUs huggingface dataset:
Application of Decision-Analytic Models in Personalized Medicine for CML Treatment Decisions Made by Payers, Providers, and Patients

As personalized medicine gains momentum, patients’ perspectives and their individual responses to treatment, including their particular disposition to side effects of therapy, will play increasingly important roles in guiding treatment decisions for physicians and their patients, as well as those involved in making reimbursement decisions in oncology. Under this emerging paradigm, undertaking analyses that strive to explain, quantify, and predict variation in treatment response by individuals is essential for informing treatment decisions, designing clinical practice guidelines, and making reimbursement decisions that are aligned with a patient-centered approach to optimize outcomes and the benefit-harm balance for each individual patient. Decisionanalytic models provide an opportunity to evaluate expected outcomes of treatments and/or biomarker-guided strategies in the management of cancer. The models can be applied to existing technologies across large populations or used to predict the impact on outcomes of technologies in development.
Dimmable Visible Light Communications Based on Multilayer ACO-OFDM

This paper proposes a dimmable scheme for a visible light communication (VLC) system based on multilayer asymmetrically clipped optical orthogonal frequency-division multiplexing (ACO-OFDM), which is able to support a wide dimming range for different illumination requirements. In the proposed scheme, multiple layers of ACO-OFDM occupying different subcarriers are combined so that almost all of the subcarriers can be used for data transmission. The polarities of different layers of ACO-OFDM are varied to obtain flexible time-domain waveform, which can fully exploit the dynamic range of light-emitting diodes (LEDs) and achieve better performance. The scaling factor and modulation order for each layer, as well as the dc bias, are optimized for different dimming requirements to achieve improved spectral efficiency. Simulation results demonstrate that the proposed scheme can support communication over a wide dimming range and achieve higher spectral efficiency, compared with existing methods under different dimming requirements.
Photopatch testing: recommendations for a European photopatch test baseline series

In order to establish a consensus recommendation for performing photopatch testing, a photopatch test taskforce group was established under the joint umbrella of the European Society for Contact Dermatitis and the European Society for Photodermatology in 2000. After proposing the most adequate methodology in 2004 and completing a European multicentre photopatch test study in 2011, this taskforce is recommending a list of photoallergens that should form part of a baseline series for photopatch testing in Europe. It contains mainly ultraviolet filters and drugs, mostly non‐steroidal anti‐inflammatory drugs. The choice of chemicals was based on the results of a recent multicentre study, previous published cases of photoallergy, and use of the substances in the European market.
Prosocial Behavior, Job Complexity, and Suggestion Contribution Under Gainsharing Plans

This article reports a study of five manufacturing organizations with performance gainsharing plans, in which 100 nonmanagement employees responded to job characteristics scales from the Job Diagnostic Survey and were evaluated by their supervisors with respect to prosocial organizational behavior. The number of suggestions employees contributed to formal employee involvement systems was found to be positively related to perceptions of job complexity. A significant interaction revealed that suggestion making was also positively related to assisting behavior (a measure of extra role prosocial behavior), but only for employees reporting that they experienced relatively high levels of job complexity. Suggestion making was not found to be related to compliance (a measure of role-prescribed prosocial behavior). The authors present implications for further research on prosocial organizational behavior and the management of high-involvement gainsharing plans.
Tradition Never Goes Out of Style: The Role of Tradition in Women’s Naming Practices

The goal of this project is to explore why, given United States women’s historical struggle to gain legal and social acceptance of nontraditional naming forms, the overwhelming majority of women continue to follow tradition and adopt their husbands’ names upon marriage. To begin to explain this phenomenon, this study focused on Catholic women, who changed their names between 1940 and 1998. This article illustrates the role tradition plays in participants’ worldview and how tradition influences their behavior and attitudes toward naming practices. The naming behaviors and attitudes of the women in this study are then analyzed within a larger sociocultural and political context.
A Clinical Guide to Pediatric Sleep: Diagnosis and Management of Sleep Problems.

Information in this volume is organized by specific disorder and by the most frequent presenting complaints. Symptom-based algorithms will enable practitioners to evaluate sleep complaints in a stepwise manner. Other features include symptom checklists for specific disorders and chapters on sleep problems in special populations. Appendices provide practical tools for screening for sleep problems, evaluating sleep studies, and counseling families.
Indicators of Lumbar Zygapophyseal Joint Pain: Survey of an Expert Panel With the Delphi Technique

Background and Purpose: The lumbar zygapophyseal joints (LZJs) are thought to be a source of low back pain (LBP); however, no valid or reliable indicators exist. The purpose of this study was to obtain a consensus from an expert panel on the indicators of LZJ pain. Subjects: A multidisciplinary panel of 20 experts in the field of LBP participated in this study. Methods: A 3-round Delphi survey designed to obtain a consensus on the indicators of LZJ pain was completed by use of accepted protocols. Subjects also were asked to justify their selection of each indicator. Results: Following the 3 rounds, consensus was achieved, and 12 indicators were identified. Those that reached the highest levels of consensus were a positive response to facet joint injection, localized unilateral LBP, positive medial branch block, pain upon unilateral palpation of the LZJ or transverse process, lack of radicular features, pain eased by flexion, and pain, if referred, located above the knee. Justifications for the experts’ selection of the indicators, predominantly based on pathoanatomical mechanisms, also were described. Discussion and Conclusion: This Delphi survey identified 12 indicators of LZJ pain, each with an associated pathoanatomical mechanism justifying selection. This survey provides preliminary validation for these indicators, which will be of value in further research into the classification and treatment of LZJ pain.
Modelling and Enhancing the Data Capacity of Wireless Sensor Networks

Energy conservation is one of the most important design considerations for battery powered wireless sensors networks (WSNET). Energy constraint in WSNETs limits the total amount of sensed data (data capacity) received by the sink. The data capacity of WSNETs is significantly affected by deployment of sensors and the sink. A major issue, which has not been adequately addressed so far, is the question of how node deployment governs the data capacity and how to improve the total data capacity of WSNETs by using non-uniform sensor deployment strategies. In this paper, we discuss this problem by analyzing the commonly used static model of sensors networks. In the static model, we find that after the lifetime of a sensor network is over, there is a great amount of energy left unused, which can be up to 90% of the total initial energy. This energy waste implies that the potential data capacity can be much larger than the capacity achieved in the static model. To increase the total data capacity, we propose two strategies: a non-uniform energy distribution model and a new routing protocol with a mobile sink. For large and dense WSNETs, both of these strategies can increase the total data capacity by an order of magnitude.
Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression

Background The human mitochondrial genome includes only 13 coding genes while nuclear-encoded genes account for 99% of proteins responsible for mitochondrial morphology, redox regulation, and energetics. Mitochondrial pathogenesis occurs in HIV patients and genetically, mitochondrial DNA haplogroups with presumed functional differences have been associated with differential AIDS progression. Methodology/Principal Findings Here we explore whether single nucleotide polymorphisms (SNPs) within 904 of the estimated 1,500 genes that specify nuclear-encoded mitochondrial proteins (NEMPs) influence AIDS progression among HIV-1 infected patients. We examined NEMPs for association with the rate of AIDS progression using genotypes generated by an Affymetrix 6.0 genotyping array of 1,455 European American patients from five US AIDS cohorts. Successfully genotyped SNPs gave 50% or better haplotype coverage for 679 of known NEMP genes. With a Bonferroni adjustment for the number of genes and tests examined, multiple SNPs within two NEMP genes showed significant association with AIDS progression: acyl-CoA synthetase medium-chain family member 4 (ACSM4) on chromosome 12 and peroxisomal D3,D2-enoyl-CoA isomerase (PECI) on chromosome 6. Conclusions Our previous studies on mitochondrial DNA showed that European haplogroups with presumed functional differences were associated with AIDS progression and HAART mediated adverse events. The modest influences of nuclear-encoded mitochondrial genes found in the current study add support to the idea that mitochondrial function plays a role in AIDS pathogenesis.
Multi-class ADTboost

This technical report gives a short review on boosting with alternating decision trees (ADTboost), which has been proposed by Freund & Mason (1999) and refined by De Comite et al. (2001). This approach is designed for two-class problems, and we extend it towards multiclass classification. The advantage of a multi-class boosting algorithm is its usage in scene interpretation with various kinds of objects. In these cases, two-class approaches will lead to several one class versus background (the other classes) classifications, where we must solve unappropriate results like ”always background” or ”two or more valid classes” for a sample.
Memory anxiety and memory performance in adulthood

The present study examined the contribution of general and domain-specific anxiety to the prediction of memory performance in a sample of 350 young, middle-aged and old adults. In a preliminary stage of this investigation, psychometric analyses revealed that the predictive validity of the Anxiety scale of the Metamemory in Adulthood questionnaire, used to assess memory-related anxiety, could be improved by using an abbreviated version of the scale. This Memory Anxiety subscale predicted level of state anxiety experienced by middle-aged and older subjects in anticipation of a memory-demanding task. It was superior to the general state measures in predicting actual memory performance, but only for the oldest age group. Results thus provide support for domain- and age-specificity in the assessment of anxiety performance relationships. Language: en
Explaining Sad People’s Memory Advantage for Faces

Sad people recognize faces more accurately than happy people (Hills et al., 2011). We devised four hypotheses for this finding that are tested between in the current study. The four hypotheses are: (1) sad people engage in more expert processing associated with face processing; (2) sad people are motivated to be more accurate than happy people in an attempt to repair their mood; (3) sad people have a defocused attentional strategy that allows more information about a face to be encoded; and (4) sad people scan more of the face than happy people leading to more facial features to be encoded. In Experiment 1, we found that dysphoria (sad mood often associated with depression) was not correlated with the face-inversion effect (a measure of expert processing) nor with response times but was correlated with defocused attention and recognition accuracy. Experiment 2 established that dysphoric participants detected changes made to more facial features than happy participants. In Experiment 3, using eye-tracking we found that sad-induced participants sampled more of the face whilst avoiding the eyes. Experiment 4 showed that sad-induced people demonstrated a smaller own-ethnicity bias. These results indicate that sad people show different attentional allocation to faces than happy and neutral people.
The Internet and Public Policy

This article looks at the role of the Internet in policymaking, identifying potential policy effects of widespread use of the Internet by citizens, firms, governments and voluntary organizations. It considers how the Internet and Internet-enabled social change might impact upon each of the four ‘tools’ of government policy — nodality, authority, treasure and organization — and how it might impact upon the mix of tools that policymakers select. It suggests a number of values normally associated with the Internet — innovation, trust, openness and equity — that might be expected to emerge in policy trends. It discusses the implications of Internet-driven change for public policy research, pinpointing some key methodologies that will become increasingly important; generation of large-scale transactional data; network analysis and experimental methods. The article argues that we cannot understand, analyse or make public policy without understanding the technological, social and economic shifts associated with the Internet — a task that the journal Policy & Internet is poised to undertake.
How do developers use parallel libraries?

Parallel programming is hard. The industry leaders hope to convert the hard problem of using parallelism into the easier problem of using a parallel library. Yet, we know little about how programmers adopt these libraries in practice. Without such knowledge, other programmers cannot educate themselves about the state of the practice, library designers are unaware of API misusage, researchers make wrong assumptions, and tool vendors do not support common usage of library constructs. We present the first study that analyzes the usage of parallel libraries in a large scale experiment. We analyzed 655 open-source applications that adopted Microsoft's new parallel libraries -- Task Parallel Library (TPL) and Parallel Language Integrated Query (PLINQ) -- comprising 17.6M lines of code written in C#. These applications are developed by 1609 programmers. Using this data, we answer 8 research question and we uncover some interesting facts. For example, (i) for two of the fundamental parallel constructs, in at least 10% of the cases developers misuse them so that the code runs sequentially instead of concurrently, (ii) developers make their parallel code unnecessarily complex, (iii) applications of different size have different adoption trends. The library designers confirmed that our finding are useful and will influence the future development of the libraries.
On Bisimilarities Induced by Relations on Actions

In this paper, we give a straightforward generalization of bisimulations to "bisimulations induced by a pair of relations" on the underlying action set. We establish that many of the nice properties of bisimulations and bisimilarities may be thought of as actually being inherited from properties of the underlying relations on actions. We show that many bisimulation-based orderings (including strong and weak bisimilarity) defined in the literature are instances of this generalization. We also show by an example that there are instances where the equivalence of two systems (which intuitively have the same functionality), cannot be established directly by observational equivalence, but requires a more general notion. We finally give an adaptation of the "on-the-fly algorithm " of Fernandez and Mourner for computing generalized bisimilarities
Molecular dynamics simulations reveal the disparity in specific recognition of GCC‐box by AtERFs transcription factors super family in Arabidopsis

Arabidopsis ethylene responsive element binding factors (AtERFs) form a transcription factor super family. While the functions of most AtERFs are unknown, a number of AtERFs appear to be involved in regulation of stress‐related genes through their DNA binding domains (DBD), namely ERF domains, which recognize a consensus motif GCC‐box at the regulatory region. In this study, molecular dynamics simulations were performed on the four ERF domain‐GCC‐box complexes, AtERF1, AtERF4, AtEBP and CFBF1, to determine disparity in specific binding to the GCC‐box by the AtERFs. Our results suggested that three amino acid residues Arg29, Glu39 and Arg41, played a vital role in direct readout of DNA. The position of the consensus sequence GCCGCC has an intrinsic disparity on binding with ERF domains. The third C, fourth G and the last C in the GCC motif was compulsory for recognition by ERF domains. Our results provide structural evidence for a sequence‐dependent recognition mechanism for AtERFs. Copyright © 2009 John Wiley & Sons, Ltd.
Energy-Efficient Hierarchical Routing Protocol for Wireless Sensor Networks

Hierarchical routing protocols are critical for the wireless sensor networks (WSN) to maximize its lifetime, but the existing protocols are prone to lead nodes in clusters to die early due to ignoring the state of neighbors in the cluster head decision. In this paper, a new cluster-based optimization algorithm is set up which optimizes clustering process, to effectively avoid the low-energy and long-distance nodes as the cluster head. Considering sink node, The object cluster head routing protocol is proposed, it ensure that only the object cluster head send overall data to sink node, which can balance energy depletion among the cluster heads in WSN. The simulation results show that the optimization strategy significantly prolongs survival time of the network, the object cluster head routing protocol reduces the unbalance of cluster heads energy dissipation caused by different distance from Sink node and maximizes the network lifetime.
Being there: ethnographic research and autobiography

Qualitative research offers a unique insight into the behaviour and beliefs and meanings of the organisations, situations and people studied. Often these meanings express themselves in narrative forms. The researcher’s own experience of research itself takes a narrative form, and has similarities with autobiography. The reflexive elements of autobiography can make for more self‐aware research, above all when the researchers are researching organisations, situations and groups of which they themselves are a part.
Hardware verification of a hyper-efficient (98%) and super-compact (2.2kW/dm3) isolated AC/DC telecom power supply module based on multi-cell converter approach

Due to the increasing electricity demand of data centers driven by the emergence of cloud computing and big data, the focus on the development of telecom and data center power supplies is shifted towards high efficiencies. In this paper, a multi-cell converter approach for a telecom rectifier module breaking through the efficiency and power density barriers of traditional single-cell converter systems is shown. The comprehensive optimization of the entire system with respect to efficiency and volume is described and the applied component loss models are explained. Furthermore, the design of a hardware demonstrator based on the optimization results is presented and several important design aspects are explained in detail.
Changes in Responsiveness to Babies during Adolescence.

FELDMAN, S. SHIRLEY, and NASH, SHARON CHURNIN. Changes in Responsiveness to Babies during Adolescence. CHILD DEVELOPMENT, 1979, 50, 942-949. Interest in babies was assessed in 30 high school seniors (16-17 years old) and 32 college freshmen (18-19 years old) by means of measures which varied from passive perceptual responses to pictures, to more active-instrumental behavioral reactivity to an actual baby in the presence, and finally in the absence of an adult. Trait theory and sociobiology predict stable sex differences across adolescence, whereas role theory anticipates sex differences during early to mid-adolescence which phase out by late adolescence. In line with role theory, there was an absence of sex differences among college students in their responses to pictures of babies and to a live baby. It was the low level of interest exhibited by high school males (e.g., physical contact, touches baby, talks to infant, disinterest in baby) that accounted for the sex differences found among high school students and the age differences apparent among males. Findings were discussed in terms of role demands for males and females at different junctures of adolescence as a function of the development and consolidation of sex-role identity.
Clustering of K-band selected local galaxies

We present a detailed clustering analysis of a large K -band selected local galaxy sample, which is constructed from the 2MASS and the SDSS and consists of 82 486 galaxies with 10 13 . 5 and 0 . 01 0 . 1 . The two-point correlation function of the magnitude-limited sample in real space at small scales is well described by the power law ξ ( r ) = ( r/ 6 . 44 ± 0 . 23) − 1 . 81 ± 0 . 02 . The pairwise velocity dispersion is derived from the anisotropic two-point correlation function and we find the dispersion σ 12 = 685 ± 17 kms -1 if scale invariance is assumed, which is larger than values measured in the optical bands of the selected galaxy samples. We further investigate the dependence of the two-point correlation function and the σ 12 on the g − r color and the K band luminosity, and obtain similar results to previous works in optical bands. Comparing a mock galaxy sample with our real data indicates that the semi-analytical model cannot mimic the σ 12 in observation, although it can approximate the two-point correlation function within measurement uncertainties.
Interpersonal Self-Perception and Memories on Parental Rearing in Alcohol Dependent Patients and Outpatient Controls

The aim of the present study is to explore the relation between interpersonal self-perceptions and memories on parental rearing taking into account the influence of alcohol dependence. Based on interpersonal and object relation theories, the existence and the directions of this relation are hypothesized. A comparative, cross-sectional study was conducted including 126 alcohol dependent inpatients (87 males, 39 females) and 119 healthy control subjects without alcohol-related problems or psychopathology (64 males, 49 females). The interpersonal self-perception was measured with the ICL-R and memories on parental rearing with the EMBU. Results show that memories on parental rearing significantly contribute to interpersonal self-perceptions especially in healthy male subjects and alcohol dependent females. Memories of rearing styles by father are most influential in female and those of mother in male. Limitations of the study are discussed, as well as some clinical implications.
Qualitative Analysis of Post-Editing for High Quality Machine Translation

In the context of massive adoption of Machine Translation (MT) by human localization services in Post-Editing (PE) workflows, we analyze the activity of post-editing high quality translations through a novel PE analysis methodology. We define and introduce a new unit for evaluating post-editing effort based on Post-Editing Action (PEA) for which we provide human evaluation guidelines and propose a process to automatically evaluate these PEAs. We applied this methodology on data sets from two technologically different MT systems. In that context, we could show that more than 35% of the remaining effort can be saved by introducing of global PEA and edit propagation.