Miracle-dz/UniFAR-FTUs huggingface dataset:
Data science ethics in government

Data science can offer huge opportunities for government. With the ability to process larger and more complex datasets than ever before, it can provide better insights for policymakers and make services more tailored and efficient. As with all new technologies, there is a risk that we do not take up its opportunities and miss out on its enormous potential. We want people to feel confident to innovate with data. So, over the past 18 months, the Government Data Science Partnership has taken an open, evidence-based and user-centred approach to creating an ethical framework. It is a practical document that brings all the legal guidance together in one place, and is written in the context of new data science capabilities. As part of its development, we ran a public dialogue on data science ethics, including deliberative workshops, an experimental conjoint survey and an online engagement tool. The research supported the principles set out in the framework as well as provided useful insight into how we need to communicate about data science. It found that people had a low awareness of the term ‘data science’, but that showing data science examples can increase broad support for government exploring innovative uses of data. But people's support is highly context driven. People consider acceptability on a case-by-case basis, first thinking about the overall policy goals and likely intended outcome, and then weighing up privacy and unintended consequences. The ethical framework is a crucial start, but it does not solve all the challenges it highlights, particularly as technology is creating new challenges and opportunities every day. Continued research is needed into data minimization and anonymization, robust data models, algorithmic accountability, and transparency and data security. It also has revealed the need to set out a renewed deal between the citizen and state on data, to maintain and solidify trust in how we use people's data for social good. This article is part of the themed issue ‘The ethical impact of data science’.
TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus

Although brain-derived neurotrophic factor (BDNF) is known to regulate circuit development and synaptic plasticity, its exact role in neuronal network activity remains elusive. Using mutant mice (TrkB-PV−/−) in which the gene for the BDNF receptor, tyrosine kinase B receptor (trkB), has been specifically deleted in parvalbumin-expressing, fast-spiking GABAergic (PV+) interneurons, we show that TrkB is structurally and functionally important for the integrity of the hippocampal network. The amplitude of glutamatergic inputs to PV+ interneurons and the frequency of GABAergic inputs to excitatory pyramidal cells were reduced in the TrkB-PV−/− mice. Functionally, rhythmic network activity in the gamma-frequency band (30–80 Hz) was significantly decreased in hippocampal area CA1. This decrease was caused by a desynchronization and overall reduction in frequency of action potentials generated in PV+ interneurons of TrkB-PV−/− mice. Our results show that the integration of PV+ interneurons into the hippocampal microcircuit is impaired in TrkB-PV−/− mice, resulting in decreased rhythmic network activity in the gamma-frequency band.
Alternative splicing of human papillomavirus type-16 E6/E6* early mRNA is coupled to EGF signaling via Erk1/2 activation

Certain types of human papillomaviruses (HPVs) are etiologically linked to cervical cancer. Their transforming capacity is encoded by a polycistronic premRNA, where alternative splicing leads to the translation of functional distinct proteins such as E6, E6*, and E7. Here we show that splicing of HPV16 E6/E7 ORF cassette is regulated by the epidermal growth factor (EGF) pathway. The presence of EGF was coupled to preferential E6 expression, whereas depletion of EGF, or treatment with EGF receptor (EGFR) neutralizing antibodies or the EGFR inhibitor tyrphostin AG1478, resulted in E6 exon exclusion in favor of E6*. As a consequence, increased p53 levels and enhanced translation of E7 with a subsequent reduction of the retinoblastoma protein pRb could be discerned. E6 exon exclusion upon EGF depletion was independent from promoter usage, mRNA stability, or selective mRNA transport. Time-course experiments and incubation with cycloheximide demonstrated that E6 alternative splicing is a direct and reversible effect of EGF signal transduction, not depending on de novo protein synthesis. Within this process, Erk1/2-kinase activation was the critical event for E6 exon inclusion, mediated by the upstream MAP kinase MEK1/2. Moreover, siRNA knockdown experiments revealed an involvement of splicing factors hnRNPA1 and hnRNPA2 in E6 exon exclusion, whereas the splicing factors Brm and Sam68 were found to promote E6 exon inclusion. Because there is a natural gradient of EGF and EGF receptor expression in the stratified epithelium, it is reasonable to assume that EGF modulates E6/E7 splicing during the viral life cycle and transformation.
Novel biallelic mutations in MSH6 and PMS2 genes: gene conversion as a likely cause of PMS2 gene inactivation

Since the first report by our group in 1999, more than 20 unrelated biallelic mutations in DNA mismatch repair genes (MMR) have been identified. In the present report, we describe two novel cases: one carrying compound heterozygous mutations in the MSH6 gene; and the other, compound heterozygous mutations in the PMS2 gene. Interestingly, the inactivation of one PMS2 allele was likely caused by gene conversion. Although gene conversion has been suggested to be a mutation mechanism underlying PMS2 inactivation, this is the first report of its involvement in a pathogenic mutation. The clinical features of biallelic mutation carriers were similar to other previously described patients, with the presence of café‐au‐lait spots (CALS), early onset of brain tumors, and colorectal neoplasia. Our data provide further evidence of the existence, although rare, of a distinct recessively inherited syndrome on the basis of MMR constitutional inactivation. The identification of this syndrome should be useful for genetic counseling, especially in families with atypical hereditary nonpolyposis colon cancer (HNPCC) associated with childhood cancers, and for the clinical surveillance of these mutation carriers. Hum Mutat 28(11), 1084–1090, 2007. © 2007 Wiley‐Liss, Inc.
Probability-Based Resource Allocation in Cognitive Radio Networks

In this paper, we propose probability-based resource allocation in cognitive radio (CR) networks to exploit the flexibility of opportunistic spectrum access (OSA). Assisted by the statistical information acquired from spectrum sensing, the proposed approach maximizes the overall utility of CR users and ensures sufficient protection of licensed users from unacceptable interference. It also supports diverse quality-of-service (QoS) requirements of multiple CR users and allows distributed implementation. Simulation results demonstrate the effectiveness of the approach as well as its advantage over any conventional approach that ignores the statistical information.
Security of office management information system analysis

Achieving office automation through network and improving work efficiency, with the popularization of computer network technology, which has become an inevitable necessity that using computer technology in office management. But in a networked office, due tocomplicated staff structure and different levels of management, people can't guarantee the safe transmission and management of documents on the net. Besides, some people involve in information sabotage on the net, causing huge losses to the State and enterprises. Therefore, people need to find a way to enhance the network security, prevent information leakage, modifying and stealing. In this article, authors discuss the security measures of office management information system; establish an information system security model based on Lotus Notes. Using a reasonable database design, security measures by integrated use of Notes and script, authors can achieve their objective to realize the system security.
Moral Foundations of Political Discourse: Comparative Analysis of the Speech Records of the US Congress and the Japanese Diet

There has been a growing body of study on the relationship between public/political discourse and its moral-emotional foundations. Most of the studies, however, have been confined to a single country's context, lacking cross-cultural perspectives. Taking a comparative perspective, we examined the emotional and moral structures of political and public discussion observed in the U.S. and Japan by employing extensive text data that cover these two countries. Specifically, we conducted dictionary-based sentiment and moral analyses of floor debate in the U.S. Congress and the Japanese Diet over a long period of time. The analyses revealed intriguing cross-national patterns in the moral-emotional framework employed in parliamentary deliberations, which cast doubt on some of the dominant arguments in the field, including, among others, J. Haidt's moral foundation hypothesis.
Asymmetrically Altered Integrity of Cingulum Bundle in Posttraumatic Stress Disorder

Previously, our group reported the altered white matter tract integrity of the left anterior cingulate in posttraumatic stress disorder (PTSD) in whole-brain exploration. Current study intended to explore whether the alteration was more prominent in any specific regions of the cingulum bundle. Diffusion tensor images of 21 PTSD subjects and 21 healthy comparison subjects were acquired. Eight isocubic regions of interest (ROIs), i.e. bilateral rostral, subgenual, dorsal, and upper cingulum bundle, were selected. Fractional anisotropy values in each ROI, which indicate the white matter tract integrity, were measured and compared between groups. Relative to comparison subjects, PTSD subjects had significantly smaller fractional anisotropy values in the left side of rostral, subgenual and dorsal cingulum bundle (26.7, 25.0, 22.2% decrease, respectively), but not in the right side ROIs. We report an asymmetrical alteration of the cingulum bundle in PTSD.
Design of Broadband Highly Efficient Harmonic-Tuned Power Amplifier Using In-Band Continuous Class (-1 ) / F Mode Transferring

A novel methodology for designing high-frequency broadband harmonic-tuned power ampli ers (PAs) is presented in this paper. Speci cally, a hybrid PA mode, transferring between continuous inverse Class-F and continuous Class-F, is for the rst time employed to design PAs with optimal performance over more than-an-octave bandwidth. A GaN PA is designed and realized based on this mode-transferring operation using a three-stage transmission-line-based low-pass matching network. Simulation and experimental results show that an in-band PA-mode transferring between continuous Class-F and continuous Class-F is successfully performed. The implemented PA achieves a measured 87% bandwidth from 1.3 to 3.3 GHz, while exhibiting a state-of-the-art performance of 10-dB gain, 60%–84% ef ciency, and 10-W output power throughout this band. Furthermore, modulated evaluation is carried out using a 300-kHz bandwidth 16-quadrature amplitude-modulation signal. Good linearity performance is measured with adjacent channel power ratio from 20 to 35 dBc and an error vector magnitude of 4%–9% over the entire bandwidth.
Process management system analysis and design of SMT reflow soldering process

Reflow soldering processes are the key processes affecting SMT product quality. First, in the paper, the essential of building SMT processes management was discussed. Then, based on the discussion, taking temperature data as the primary object, process management system analysis of reflow soldering processes was achieved from three aspects: temperature data acquisition, long-distance temperature data transmission and process management software design of reflow soldering processes. At last, general structure of system was advanced and process management system of SMT reflow soldering processes was built through hardware and software designs. The system can promote the improvement of process management ability and level of reflow soldering processes.
Finger Sequence Learning in Adults Who Stutter

Originary neurogenic, non-syndromatic stuttering has been linked to a dysfunctional sensorimotor system. Studies have demonstrated that adults who stutter (AWS) perform poorly at speech and finger motor tasks and learning (e.g., Smits-Bandstra et al., 2006b; Namasivayam and van Lieshout, 2008). The high relapse rate after stuttering treatment could be a further hint for deficient motor learning and, in particular, for the limited generalization of the learned technique in daily communication. In this study, we tested generalization of finger sequence skills in AWS using an effector-dependent transfer task after a 24-h retention period. Additionally, we wanted to corroborate previous motor learning results in AWS for practice and retention: 16 AWS and 16 age-, sex-, and education-matched controls performed the task during four test sessions. Our results indicate that generalization performance in AWS was not inferior to that of fluent controls. In addition, we found, contrary to previous results, that AWS showed a steeper learning progress after practice and consolidation compared with controls. We suggest that with sufficient practice and a 24-h consolidation phase, AWS are able to retain the learned performance of tapping a five-item finger sequence as well as fluent controls in terms of speed and accuracy.
Structural balance in fully signed networks

Node attributes play an important role in shaping network structures, but are generally ignored in transformations of structural balance. A fully signed network consisting of signs of edges and nodes expresses both properties of relationship and node attributes. In this article, we generalize the definition of structural balance in fully signed networks. We transform the unbalanced fully signed network by not only changing signs of edges but also changing the signs of nodes. We propose a memetic algorithm to transform unbalanced networks at the lowest cost. Experiments show that our algorithm can solve this problem efficiently, and different node attribute assignments may lead to different optimized structures. © 2016 Wiley Periodicals, Inc. Complexity, 2016
Comparing Treatment Relevant Etiological Explanations for Depression and Social Anxiety: Effects on Self-Stigmatizing Attitudes

This study examines the impact of three different etiological explanations on self-stigmatizing attitudes among individuals with clinical symptom levels of either major depressive disorder (MDD; n = 144) or social anxiety disorder (SAD; n = 175). Participants were randomly assigned to view an audiovisual presentation describing their symptoss as being caused by biological (BIO) or cognitive-behavioral (CB) factors, or their combination (BIO+CB). Self-blame and perceived helplessness were significantly greater in the CB condition compared to the BIO condition. There was no significant difference in prognostic pessimism, perceived dangerousness, and unpredictability between the CB and BIO conditions. All self-stigmatizing attitudes were worse in the BIO+CB condition compared to the BIO condition. The MDD group endorsed significantly higher levels of self-stigmatizing attitudes compared to the SAD group. The present findings suggest that cognitive-behavioral etiological explanations may increase self-stigma .
‘You just deal with it. You have to when you’ve got a child’: A narrative analysis of mothers’ accounts of how they coped, both during an abusive relationship and after leaving

A narrative analysis explored the accounts of eight mothers, each of whom had left an abusive relationship at least 12 months previously. Existing research investigating the strategies used by women to cope with domestic violence rarely considers women in their capacity as mothers. Furthermore, women’s lives after leaving an abusive relationship have received limited research attention. Thus, this study aimed to understand how women described coping with domestic violence and mothering their children, both during an abusive relationship and after leaving. The analysis focused on how the eight participants described their experiences (narrative form) as well as what they talked about (narrative content). Three types of narrative form were identified: (1) ‘The story told to help others’, (2) ‘The story too difficult to tell’ and (3) ‘Where’s my story going? ’ Each woman spoke about the contextual factors that influenced whether she coped with domestic violence by seeking support from others, changing her thinking or changing her behaviour. Caring for their children was a major source of support for all the women both during their relationship and after leaving. The findings indicate that mothers who have been abused by their intimate partner may come into contact with a wide range of social and emergency support services. Implications for clinical practice, service delivery and service development relate to the different ways of supporting women in talking about abuse and also the need to recognise trauma in parents.
Associative and Identity Words Promote the Speed of Visual Categorization: A Hierarchical Drift Diffusion Account

Words can either boost or hinder the processing of visual information, which can lead to facilitation or interference of the behavioral response. We investigated the stage (response execution or target processing) of verbal interference/facilitation in the response priming paradigm with a gender categorization task. Participants in our study were asked to judge whether the presented stimulus was a female or male face that was briefly preceded by a gender word either congruent (prime: “man,” target: “man”), incongruent (prime: “woman,” target: “man”) or neutral (prime: “day,” target: “man”) with respect to the face stimulus. We investigated whether related word-picture pairs resulted in faster reaction times in comparison to the neutral word-picture pairs (facilitation) and whether unrelated word-picture pairs resulted in slower reaction times in comparison to neutral word-picture pairs (interference). We further examined whether these effects (if any) map onto response conflict or aspects of target processing. In addition, identity (“man,” “woman”) and associative (“tie,” “dress”) primes were introduced to investigate the cognitive mechanisms of semantic and Stroop-like effects in response priming (introduced respectively by associations and identity words). We analyzed responses and reaction times using the drift diffusion model to examine the effect of facilitation and/or interference as a function of the prime type. We found that regardless of prime type words introduce a facilitatory effect, which maps to the processes of visual attention and response execution.
Effects of BDNF Signaling on Anxiety-Related Behavior and Spatial Memory of Adolescent Rats in Different Length of Maternal Separation

As an adverse form of early-life stress (ELS), maternal separation (MS) can interfere with the development of cognition and behaviors of adolescent rodents. Brain-derived neurotrophic factor (BDNF) is involved in the regulation of brain development and function, but the molecular mechanisms by which BDNF regulates brain function and behavior in MS with different stressor strengths remain unclear. This descriptive study characterized the levels of BDNF in the prefrontal cortex (PFC) and plasma corticosterone (CORT) from the offspring of rats exposed to early handling (EH, 15-min separation per day) and prolonged MS (PMS, 180-min separation per day), during postnatal days (PND) 1‑21. The behavioral and biochemical analyses were performed during adolescence (PND 42‑56). PMS resulted in reduced weight and decreased locomotor activity in the open field test and Y-maze task compared to control (CON) group, with EH showing an intermediate phenotype. BDNF protein levels in the PFC were lower in PMS compared to EH and further reduced in CON male rats. Plasma CORT levels were higher in PMS compared to CON with EH again showing intermediate levels. Neither PMS or EH affected spatial learning in the Y-maze task. These findings indicate that longer periods of maternal separation are necessary to increase anxiety-like behavior, elevate CORT levels, and further suppress BDNF levels in the PFC, providing a possible mechanism to explain why more severe forms of ELS lead to more significant psychiatric and medical consequences later in life.
ESTRO : Design and Development of Intelligent Autonomous Vehicle for Shuttle Service in the ETRI

 Road Recognition and Obstacle Detection • The extrinsic calibration is based on observing a planar checkerboard pattern. • On-road markers such as lane, speed bump, crosswalk, and stop line are detected in image using Hough transformation. • Curb is detected with laser sensor on the top of the vehicle using particle filter algorithm. • Both size and distance of obstacles on the road are simply detected by laser sensor at the front of the vehicle.  Rule-based Behavior Planning • ESTRO can select proper behaviors corresponding to road environment for driving safely and efficiently. • Five driving modes : normal road, crosswalk, speed bump, intersection, and obstacle avoidance driving mode.
Induction of CD4+ T cell-dependent CD8+ type 1 responses in humans by a malaria DNA vaccine

We assessed immunogenicity of a malaria DNA vaccine administered by needle i.m. or needleless jet injection [i.m. or i.m. /intradermally (i.d.)] in 14 volunteers. Antigen-specific IFN-γ responses were detected by enzyme-linked immunospot (ELISPOT) assays in all subjects to multiple 9- to 23-aa peptides containing class I and/or class II restricted epitopes, and were dependent on both CD8+ and CD4+ T cells. Overall, frequency of response was significantly greater after i.m. jet injection. CD8+-dependent cytotoxic T lymphocytes (CTL) were detected in 8/14 volunteers. Demonstration in humans of elicitation of the class I restricted IFN-γ responses we believe necessary for protection against the liver stage of malaria parasites brings us closer to an effective malaria vaccine.