Miracle-dz/UniFAR-FTUs huggingface dataset:
Failed Cartilaginous Grafts in the Eyelid: A Retrospective Clinicopathological Analysis of 5 Cases

Purpose: To analyze the clinical and histopathologic features of 5 failed autologous cartilaginous grafts to the lower eyelids and to analyze the reasons for these failures. Methods: In this retrospective case series, the data collected included patient ages, reasons for and duration of cartilaginous graft implants, sources of cartilaginous grafts, and clinical and histopathologic findings at time of graft removal using hematoxylin and eosin, elastic, Alcian blue, and Masson trichrome staining for analysis of tissue alterations. Results: Five cartilaginous, posterior lamellar lower eyelid grafts were complicated by eyelid thickening or retraction, graft extrusion, and entropion. Histopathologic findings included segmentation of the original single implant, stripped of its perichondrium, due to “kerfing,” sometimes with overlapping of the segments and scar formation between the segments. In place of the perichondrium that had been removed during the preparation the graft implants, a fibrous pseudoperichondrial capsule had formed. Pyknotic nuclei in varying degrees were typically found in the center of the grafts, despite a high degree of preservation of the extracellular matrix (collagenous, elastic, and proteoglycan components). No evidence of inflammation, cartilaginous vascularization, or necrosis was identified in any graft. Conclusion: Despite minimal reactive processes, kerfing (partial thickness cuts made in the graft to increase its pliancy) may be partially responsible for graft migration, deformation, and surgical failure. The consequences were graft fragmentation and overlapping of the multiple fragments. Graft migration can be exacerbated if a posterior lamellar graft is used to correct an anterior lamellar deficiency. Interference with the overall architectural integrity of the graft and its extracellular matrix appears to play no role in failure, despite removal of the perichondrium. Mild to moderate degrees of chondrocytic dropout in the absence of necrosis and inflammation are probably attributable to the thick and coarsely textured collagen of the fibrous pseudoperichondrial capsule that may impede diffusion of nutrients into the center of the graft.
In Vitro Assays of Chemotaxis as a Window into Mechanisms of Toxicant‐Induced Immunomodulation

Dysregulated cell movement can lead to developmental abnormalities, neoplasia, and immune system disorders, and there are a variety of contexts in which xenobiotics (and biologic) effects on this movement are of interest. Many toxins and toxicants have been shown to disrupt controlled cell movement. Identification of compounds that affect cell movement is crucial to drug discovery. Drug components may have unexpected consequences with respect to cell motility, which would exclude these compounds in drug development. Finally, the development of drugs that target chemotactic pathways may be useful in the treatment of tumors, which often reprogram chemotactic pathways to become metastatic. The effects of these agents on cell movement can be measured using several different in vitro chemotactic assays. This review details the procedures of three in vitro measurements of chemotaxis: the Boyden chamber, the under‐agarose assay, and the automated, real‐time, ECIS/Taxis assay, and discusses the inferences that can be drawn from the results of such studies. Curr. Protoc. Toxicol. 58:18.17. 1‐18.17. 24. © 2013 by John Wiley & Sons, Inc.
International Conference Future Buildings & Districts Energy E ffi ciency from Nano to Urban Scale , CISBAT 2017 6-8 September 2017 , Lausanne , Switzerland Interactive opti ization for the planning of urban syste s

District heating networks are commonly addressed in the literature as one of the most effective solutions for decreasing the greenhouse gas emissions from the building sector. These systems require high investments which are returned through the heat sales. Due to the changed climate conditions and building renovation policies, heat demand in the future could decrease, prolonging the investment return period. The main scope of this paper is to assess the feasibility of using the heat demand – outdoor temperature function for heat demand forecast. The district of Alvalade, located in Lisbon (Portugal), was used as a case study. The district is consisted of 665 buildings that vary in both construction period and typology. Three weather scenarios (low, medium, high) and three district renovation scenarios were developed (shallow, intermediate, deep). To estimate the error, obtained heat demand values were compared with results from a dynamic heat demand model, previously developed and validated by the authors. The results showed that when only weather change is considered, the margin of error could be acceptable for some applications (the error in annual demand was lower than 20% for all weather scenarios considered). However, after introducing renovation scenarios, the error value increased up to 59.5% (depending on the weather and renovation scenarios combination considered). The value of slope coefficient increased on average within the range of 3.8% up to 8% per decade, that corresponds to the decrease in the number of heating hours of 22-139h during the heating season (depending on the combination of weather and renovation scenarios considered). On the other hand, function intercept increased for 7.8-12.7% per decade (depending on the coupled scenarios). The values suggested could be used to modify the function parameters for the scenarios considered, and improve the accuracy of heat demand estimations. © 2017 The Authors. Published by Elsevier Ltd. Peer-review under responsibility of the Scientific Committee of The 15th International Symposium on District Heating and Cooling.
Data-centric dynamic partial order reduction

We present a new dynamic partial-order reduction method for stateless model checking of concurrent programs. A common approach for exploring program behaviors relies on enumerating the traces of the program, without storing the visited states (aka stateless exploration). As the number of distinct traces grows exponentially, dynamic partial-order reduction (DPOR) techniques have been successfully used to partition the space of traces into equivalence classes (Mazurkiewicz partitioning), with the goal of exploring only few representative traces from each class. We introduce a new equivalence on traces under sequential consistency semantics, which we call the observation equivalence. Two traces are observationally equivalent if every read event observes the same write event in both traces. While the traditional Mazurkiewicz equivalence is control-centric, our new definition is data-centric. We show that our observation equivalence is coarser than the Mazurkiewicz equivalence, and in many cases even exponentially coarser. We devise a DPOR exploration of the trace space, called data-centric DPOR, based on the observation equivalence. For acyclic architectures, our algorithm is guaranteed to explore exactly one representative trace from each observation class, while spending polynomial time per class. Hence, our algorithm is optimal wrt the observation equivalence, and in several cases explores exponentially fewer traces than any enumerative method based on the Mazurkiewicz equivalence. For cyclic architectures, we consider an equivalence between traces which is finer than the observation equivalence; but coarser than the Mazurkiewicz equivalence, and in some cases is exponentially coarser. Our data-centric DPOR algorithm remains optimal under this trace equivalence. Finally, we perform a basic experimental comparison between the existing Mazurkiewicz-based DPOR and our data-centric DPOR on a set of academic benchmarks. Our results show a significant reduction in both running time and the number of explored equivalence classes.
OBSERVATIONAL TIMING STUDY ON THE SAT REASONING TEST™ FOR TEST-TAKERS WITH LEARNING DISABILITIES AND/OR AD/HD

The purpose of this study is to provide information on actual time used by students with disabilities on the new SAT®. This study observed students with learning disabilities (LD) and/or attention deficit/hyperactivity disorder (AD/HD) as they took SAT items under strict time limits and recorded the amount of time taken for each item. The study is a replication of study 2 in Bridgeman, Cahalan, and Cline (2003), which observed students without disabilities completing the same test items that are included in this study. Comparisons of the results from this study to the results of Bridgeman et al. are made and recommendations on appropriate extended-time limits for most students with disabilities are provided.
Can Composers Express Emotions through Music?

This study investigated the possibility that musical composers can reliably convey distinct and definable emotional qualities through pitch, temporal and loudness information contained in a musical score. Five musical composers were provided with a list of six terms relating to emotional states. The terms were: joy, sorrow, excitement, dullness, anger and peace. Each composer was asked to compose short melodies embodying the emotional qualities described by the six terms. Fourteen listeners were played the melodies, and were asked to provide judgments relating to their emotional quality. Melodies were judged to embody the emotional quality intended to be conveyed. Unintended emotional qualities were judged to be present in melodies in varying degrees. The notion that emotional qualities can be effectively conveyed through music is discussed.
Usefulness of ultrasound elastography in reducing the number of Breast Imaging Reporting and Data System category 3 lesions on ultrasonography

Purpose: To evaluate the negative predictive value (NPV) of ultrasound (US) elastography for non-palpable Breast Imaging Reporting and Data System (BI-RADS) category 3 lesions on ultrasonography and to determine whether US elastography is helpful in reducing the number of BI-RADS category 3 lesions on ultrasonography. Methods: Two hundred seventy-six consecutive, non-palpable BI-RADS category 3 lesions in 256 women who underwent US elastography and US-guided core biopsy, and who had at least 12 months of follow-up data, comprised our study group. The BI-RADS final assessment category and elasticity score were prospectively and independently classified. The rate of malignancy and NPV according to the elasticity score were analysed. We also investigated whether there was a subset of BI-RADS category 3 lesions that were of benign histology but negative on elastography. Results: Of the 276 non-palpable BI-RADS category 3 lesions, three lesions (1.0%) were finally confirmed as ductal carcinomas in situ. No cancers were found in the remaining 273 lesions with benign biopsy histology at a mean follow-up of 39.4 months (range, 12 to 72 months). The NPV of a negative elasticity score (elasticity score of 1) was 99.3% (165 of 166). If BI-RADS category 3 lesions showing a negative elasticity score were downgraded to BI-RADS category 2, 60.4% (165 of 273) of them with benign histology could have been safely followed without biopsy with an increased malignancy rate from 1% (3 of 276) to 1.8% (2 of 110), which is not significantly higher (P=0.626). Conclusion: US elastography has the potential to reduce the number of BI-RADS category 3 lesions on ultrasonography.
Hypercoagulability and haemodynamic abnormalities in atrial fibrillation.

Non-valvar atrial fibrillation confers a substantial risk for stroke and thromboembolism which is estimated to be between 4-5% and 12% per year depending on associated risk factors. '2 Recent studies have established the value of warfarin as thromboprophylaxis in atrial fibrillation; however, this treatment carries with it the inconvenience of regular monitoring of anticoagulation intensity and the risk of bleeding. ' 2 Attention has therefore focused on the development of alternative, safe, and convenient antithrombotic regimens, and appropriate thromboembolic risk stratification. For example, a low intensity fixed dose warfarin-aspirin regimen has certain attractions for convenience, but the recent third Stroke Prevention in Atrial Fibrillation study demonstrated the lower efficacy of this regimen compared with conventional, adjusted dose, warfarin therapy.3 Careful risk stratification has also been advocated to ensure that patients with atrial fibrillation at high risk of stroke and thromboembolism receive warfarin, while low risk patients are at least treated with aspirin. A strategy of prescribing warfarin to every patient with atrial fibrillation, irrespective of risk stratification, may increase risk of bleeding, particularly intracranial haemorrhage, and cause unnecessary inconvenience to patients.4 Most risk stratification can be performed on clinical criteria alone, with some refinement of risk stratification using echocardiography.2 However, other developments to assist thromboembolic risk stratification are needed; one area may be the study of various haemostatic and clotting indices that suggest a hypercoagulable state. As long as 150 years ago, Virchow5 postulated three components for thrombogenicity: abnormalities in the blood vessel wall, blood flow, and blood constituents. These three basic postulates appear to be fulfilled in patients with atrial fibrillation. Clinical and echocardiographic criteria may help identify the first two of Virchow's basic postulates for thrombogenesis-abnormalities of vessels and blood flow, such as heart valve disease and cardiac impairment. It is also well recognised that atrial fibrillation confers a hypercoagulable state, satisfying the third ofVirchow's postulates.6 The hypercoagulable state in chronic atrial fibrillation appears to be independent of the underlying aetiology or any structural heart disease, including left atrial size or left ventricular function.79 Patients with paroxysmal atrial fibrillation have also been shown to demonstrate abnormalities of haemostasis'"II related to the duration of a paroxysm of atrial fibrillation and whether the patient was in atrial fibrillation at the time of sampling. " l Patients who are started
Dexamethasone for ocular inflammation

Introduction: Corticosteroids, administered systemically and periocularly, have long been used to treat intermediate and posterior segment noninfectious uveitis. In addition to systemic immunosuppressive medications, these therapies are used to reduce inflammation, prevent structural complications and prevent long-term visual loss in patients with uveitis. While systemic immunosuppressive therapies carry their own set of side effects, treatment with local steroids is associated with the risk of development of cataract and glaucoma. Areas covered: Intravitreal delivery of fluocinolone acetonide via a sustained-release implant (Retisert) was approved by the FDA in 2005 for the treatment of noninfectious intermediate and posterior uveitis. Recently, the FDA also approved the biodegradable dexamethasone implant (Ozurdex) for the treatment of noninfectious uveitis involving the posterior segment. Expert opinion: The single injection, 26-week data indicate that the implant is well tolerated and produces meaningful improvements in intraocular inflammation and visual acuity that persist through 6 months. The available 6-month data also indicate that this implant confers much less of a risk of ocular hypertension than other forms of intraocular steroid therapy. However, future longer-term trials are needed to evaluate the efficacy and safety data in patients who receive multiple injections. The newly approved dexamethasone implant, Ozurdex, is a useful addition to our local armamentarium in the treatment of noninfectious intermediate and posterior uveitis given its efficacy, safety, and ease of use in the outpatient setting.
A Minimal Murine Msx-1 Gene Promoter

To dissect the cis-regulatory elements of the murine Msx-1 promoter, which lacks a conventional TATA element, a putative Msx-1 promoter DNA fragment (from −1282 to +106 base pairs (bp)) or its congeners containing site-specific alterations were fused to luciferase reporter and introduced into NIH3T3 and C2C12 cells, and the expression of luciferase was assessed in transient expression assays. The functional consequences of the sequential 5′ deletions of the promotor revealed that multiple positive and negative regulatory elements participate in regulating transcription of theMsx-1 gene. Surprisingly, however, the optimal expression of Msx-1 promoter in either NIH3T3 or C2C12 cells required only 165 bp of the upstream sequence to warrant detailed examination of its structure. Therefore, the functional consequences of site-specific deletions and point mutations of the cis-acting elements of the minimalMsx-1 promoter were systematically examined. Concomitantly, potential transcriptional factor(s) interacting with thecis-acting elements of the minimal promoter were also studied by gel electrophoretic mobility shift assays and DNase I footprinting. Combined analyses of the minimal promoter by DNase I footprinting, electrophoretic mobility shift assays, and super shift assays with specific antibodies revealed that 5′-flanking regions from −161 to −154 and from −26 to −13 of the Msx-1 promoter contains an authentic E box (proximal E box), capable of binding a protein immunologically related to the upstream stimulating factor 1 (USF-1) and a GC-rich sequence motif which can bind to Sp1 (proximal Sp1), respectively. Additionally, we observed that the promoter activation was seriously hampered if the proximal E box was removed or mutated, and the promoter activity was eliminated completely if the proximal Sp1 site was similarly altered. Absolute dependence of theMsx-1 minimal promoter on Sp1 could be demonstrated by transient expression assays in the Sp1-deficient Drosophilacell line cotransfected with Msx-1-luciferase and an Sp1 expression vector pPacSp1. The transgenic mice embryos containing −165/106-bp Msx-1 promoter-LacZ DNA in their genomes abundantly expressed β-galactosidase in maxillae and mandibles and in the cellular primordia involved in the formation of the meninges and the bones of the skull. Thus, the truncated murine Msx-1promoter can target expression of a heterologous gene in the craniofacial tissues of transgenic embryos known for high level of expression of the endogenous Msx-1 gene and found to be severely defective in the Msx-1 knock-out mice.
CARDS: cluster-aware remote disks

This paper presents Cluster-Aware Remote Disks (CARDs), a Single System I/O architecture for cluster computing. CARDs virtualize accesses to remote cluster disks over a System Area Network. Their operation is driven by cooperative caching policies that implement a joint management of the cluster caches. All the CARDS of a given disk employ a common policy, independently of other CARD sets. CARD drivers have been implemented as Linux kernel modules which can flexibly accommodate various cooperative caching algorithms. We designed and implemented a decentralized policy called Home-based Serverless Cooperative Caching (HSCC). HSCC showed cache hit ratios over 50% for workloads that go beyond the limit of the global cache. The best speedup of a CARD over a remote disk interface was 1.54.
The spirituality of young Australians

A research project conducted in 2003–2006, the Spirit of Generation Y, using both extended interviews and a nationwide survey, revealed three main strands in the spirituality of young Australians: traditional, alternative and humanist. Their involvement in traditional religions was declining, like that of their parents, and although some adopted alternative spiritualities, the stronger trends were toward indifference or humanism. Eclecticism in worldviews and cautiously relativistic values seem to be responses to an uncertain world, in which isolated individuals have only fragile support structures for their identity.
Endurance of Multiplication Fact Fluency for Students With Attention Deficit Hyperactivity Disorder

This study examines the relationship between a critical learning outcome of behavioral fluency and endurance, by comparing the effects of two practice procedures on multiplication facts two through nine. The first procedure, called whole time practice trial, consisted of an uninterrupted 1 minute practice time. The second procedure, endurance building practice trials, had three 20 second practice trials. A total of 3 students with attention deficit hyperactivity disorder participated. Results indicated that multiplication facts with the endurance building practice trials produced more efficient learning when compared to the whole time practice trial procedure for all 3 participants. Additionally, results show that even with the amount of practice time being equal, 1 minute in both conditions, on average participants practiced 30% more problems with the endurance building practice trials procedure than they did with the whole time practice trial procedure.
Applying Kinect on the Development of a Customized 3D Mannequin

— In the field of fashion design, 3D Mannequin is a kind of assisting tool which could rapidly realize the design concepts. While the concept of 3D Mannequin is applied to the computer added fashion design, it will connect with the development and the application of design platform and system. Thus, the situation mentioned above revealed a truth that it is very critical to develop a module of 3D Mannequin which would correspond with the necessity of fashion design. This research proposes a concrete plan that developing and constructing a system of 3D Mannequin with Kinect. In the content, ergonomic measurements of objective human features could be attained real-time through the implement with depth camera of Kinect, and then the mesh morphing can be implemented through transformed the locations of the control-points on the model by inputting those ergonomic data to get an exclusive 3D mannequin model. In the proposed methodology, after the scanned points from the Kinect are revised for accuracy and smoothening, a complete human feature would be reconstructed by the ICP algorithm with the method of image processing. Also, the objective human feature could be recognized to analyze and get real measurements. Furthermore, the data of ergonomic measurements could be applied to shape morphing for the division of 3D Mannequin reconstructed by feature curves. Due to a standardized and customer-oriented 3D Mannequin would be generated by the implement of subdivision, the research could be applied to the fashion design or the presentation and display of 3D virtual clothes. In order to examine the practicality of research structure, a system of 3D Mannequin would be constructed with JAVA program in this study. Through the revision of experiments the practicability-contained research result would come out.
General intellectual capacity of young men with cleft lip with or without cleft palate and cleft palate alone

We report on the general intellectual capacity of men around 17–19 years of age and with cleft lip either with or without cleft palate (CLP) or cleft palate alone. Data were obtained from the Swedish National Service enrolment register for the years 1991–1997, about 335 individuals with CLP and 88 with cleft palate alone, who were compared with a control group consisting of 272 879 people. Those with CLP showed no significant differences compared with the control group. The group with cleft palate alone had significantly lower general intellectual scores than the control group.