Miracle-dz/UniFAR-FTUs huggingface dataset:
Plato's SYMPOSIUM.

This is the first full-length study of the Symposium to be published in English, and one of the first English works on Plato to take its bearings by the dramatic form of the Platonic dialogue, a thesis that was regarded as heterodox at the time but which today is widely accepted by scholars of the most diverse standpoint. Rosen was also one of the first to study in detail the philosophical significance of the phenomenon of concrete human sexuality, as it is presented by Plato in the diverse characters of the main speakers in the dialogue. His analysis of the theoretical significance of pederasty in the dialogue was highly controversial at the time, but is today accepted as central to Plato's dramatic phenomenology of human existence.Rosen discusses a variety of topics that had previously been neglected in the secondary literature, including the problem of the hybristic nature of the philosopher, the poetical dimension of Plato's conception of philosophy, and the theoretical implication of the difference between Platonic writing and Socratic conversation.
Ultrasound guided percutaneous thrombin injection of iatrogenic femoral artery pseudoaneurysms after coronary angiography and intervention

Ultrasound guided percutaneous thrombin injection has recently been described for the treatment of iatrogenic femoral pseudoaneurysms. Patient selection and technical aspects of this technique are still evolving and safety data, particularly after coronary intervention, remains limited. The percutaneous thrombin injection of femoral artery pseudoaneurysms in 13 consecutive patients, most of whom were receiving antiplatelet/anticoagulant treatment (aspirin 11, heparin 4, clopidogrel 6), is reported. Thrombin (1000 U/ml) was injected over several seconds until Doppler colour flow within the cavity ceased. The median dose of thrombin injected was 800 U (range 200–1000 U) and the treatment was successful in all cases without complication. In one case, thrombus was visualised within the arterial lumen immediately after thrombin injection, but this dissolved spontaneously within five minutes without evidence of embolisation. In contrast to ultrasound guided compression, percutaneous thrombin injection of femoral pseudoaneurysms is a rapid, well tolerated, and successful technique even in patients receiving antiplatelet/anticoagulant treatment.
Delay analysis for optical wireless multihop networks

Visible Light Communication (VLC) is a new emerging technology, where delay is a Quality of Service (QoS) criterion for communication. This paper presents an analysis of the theoretically possible end-to-end delay and hop number for Light on Demand (LoD) and VLC-based multihop networks. Taking the human eye perception as a relevant parameter, total delay is analyzed at the Open Systems Interconnection (OSI) layers 1-3. The main goal was to determine a number of hops to achieve remote dimming when the additional harmful perceptions are simultaneously avoided. Based upon the presented simulation results, the main reasons for end-to-end delay are the data rate, the number of retransmissions, the processing time and the number of hops. Hence, employing VLC leads to the limiting number of hops for certain channel, interferer, hardware and eye sensitivity.
DroidCIA: A Novel Detection Method of Code Injection Attacks on HTML5-Based Mobile Apps

Smartphones have become more and more popular recently. There are many different smartphone systems, such as Android, iOS, etc. Based on HTML5, now developers can have a convenient framework to develop cross-platform HTML5- based mobile apps. Unfortunately, HTML5-based apps are also susceptible to cross-site scripting attacks like most web applications. Attackers can inject malicious scripts from many different injection channels. In this paper, we propose a new way to detect a known malicious script injected by using HTML5 text box input type along with "document.getElementById("TagID"). value". This new text box injection channel was not detected by other researchers so far because they only analyzed JavaScript APIs, but overlooked HTML files which captured text box input type information. Later, we applied this new method to a vulnerable app set with 8303 cases obtained from Google Play. We detected a total of 351 vulnerable apps with accuracy 99%, which included 347 detected also by other researchers as well as 4 extra vulnerable apps that belonged to this text box injection channel. We also implemented a Code Injection Attack detection tool named DroidCIA that automated the drawing of JavaScript API call graph and the combination of API with HTML information.
LawVille : a Collaborative Serious Game

SGs are (digital) games used for purposes other than mere entertainment using leaning-by-doing paradigm. Current internet technologies increase the capabilities of Web-Based Serious Games making them collaborative e-learning instruments. This paper presents LawVille, a Web-Based Collaborative Serious Game aimed at teaching citizenship and the Italian Constitution to secondary school students.
Major trends in the imaging sciences: 2007 Eugene P. Pendergrass New Horizons Lecture.

Editor’s Note: The video recording of Dr Zerhouni’s 2007 Eugene P. Pendergrass New Horizons Lecture, complete with audio, images, and movies, is available for viewing at http: //www.rsna. org/GeneralSessions /Zerhouni/index.html. This article is a slightly abridged version of the lecture.
Logo Detection Using Painting Based Representation and Probability Features

In this paper, a coarse-to-fine logo detection scheme for document images is proposed. At the coarse level of the proposed scheme, content of a document image is pruned utilizing a decision tree and a small number of features such as frequency probability (FP), Gaussian probability (GP), height, width, and average density computed for patches. The patches are extracted employing the piece-wise painting algorithm (PPA) used for text-line segmentation. The fine level of the proposed scheme refines the detection results by integrating shape context descriptors and a Nearest Neighbor (NN) classifier. We evaluated the proposed approach using a public and two large industrial datasets. From the experiment on Tobacco-800 dataset, the best precision and accuracy of 75.25% and 91.50% were obtained respectively.
Orchestrating Proactive and Reactive Mechanisms for Filtering Distracting Information: Brain-Behavior Relationships Revealed by a Mixed-Design fMRI Study

Given the information overload often imparted to human cognitive-processing systems, suppression of irrelevant and distracting information is essential for successful behavior. Using a hybrid block/event-related fMRI design, we characterized proactive and reactive brain mechanisms for filtering distracting stimuli. Participants performed a flanker task, discriminating the direction of a target arrow in the presence versus absence of congruent or incongruent flanking distracting arrows during either Pure blocks (distracters always absent) or Mixed blocks (distracters on 80% of trials). Each Mixed block had either 20% or 60% incongruent trials. Activations in the dorsal frontoparietal attention network during Mixed versus Pure blocks evidenced proactive (blockwise) recruitment of a distraction-filtering mechanism. Sustained activations in right middle frontal gyrus during 60% Incongruent blocks correlated positively with behavioral indices of distraction-filtering (slowing when distracters might occur) and negatively with distraction-related behavioral costs (incongruent vs congruent trials), suggesting a role in coordinating proactive filtering of potential distracters. Event-related analyses showed that incongruent trials elicited greater reactive activations in 20% (vs 60%) Incongruent blocks for counteracting distraction and conflict, including in the insula and anterior cingulate. Context-related effects in occipitoparietal cortex consisted of greater target-evoked activations for distracter-absent trials (central-target-only) in Mixed versus Pure blocks, suggesting enhanced attentional engagement. Functional-localizer analyses in V1/V2/V3 revealed less distracter-processing activity in 60% (vs 20%) Incongruent blocks, presumably reflecting tonic suppression by proactive filtering mechanisms. These results delineate brain mechanisms underlying proactive and reactive filtering of distraction and conflict, and how they are orchestrated depending on distraction probability, thereby aiding task performance. SIGNIFICANCE STATEMENT Irrelevant stimuli distract people and impair their attentional performance. Here, we studied how the brain deals with distracting stimuli using a hybrid block/event-related fMRI design and a task that varied the probability of the occurrence of such distracting stimuli. The results suggest that when distraction is likely, a region in right frontal cortex proactively implements attentional control mechanisms to help filter out any distracting stimuli that might occur. In contrast, when distracting input occurs infrequently, this region is more reactively engaged to help limit the negative consequences of the distracters on behavioral performance. Our results thus help illuminate how the brain flexibly responds under differing attentional demands to engender effective behavior.
A Multibiometric Approach in a Semi Automatic Dental Recognition Using DIFT Technique and Dental Shape Features

Teeth are one of the most important and popular biometric characteristic used in Forensic Dentistry. The development of automatic or semiautomatic, robust and precise forensic human identification systems are crucial for forensic, principally in mass disasters, like tsunamis and airplanes crashes. In this work we propose the use of the Differential Image Foresting Transform (DIFT) to extract the teeth and dental work contours from panoramic dental radiographs that are used as dental features. The shape descriptors based on the Shape Context method and Beam Angle Statistics (BAS) were implemented and evaluated for the teeth recognition. The Dental Code technique was used to evaluate all dental works, including the restorations. The experiments were carry out using a database of 1126 teeth images, obtained from 40 panoramic dental radiograph images from 20 individuals. The multibiometric approach improved the system performance generating, in the best case, an EER of 9%. KeywordsMultibiometrics; Forensic Dentistry; Dental Recognition; Image Forest Transform; Shape Context, Beam Angle Statistics, Edit Distance.
An NPPB Promoter Polymorphism Associated With Elevated N‐Terminal pro–B‐Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality

Background Elevated B‐type natriuretic peptide (BNP) levels are associated with heart failure and increased mortality in the general population. We investigated rs198389, a functional variant in the promoter region of the BNP gene (NPPB), in patients from the Atherosclerosis Risk in Communities Study to investigate associations with N‐terminal pro‐BNP (NT‐proBNP) levels and outcomes. Methods and Results A total of 11 361 black and white patients with rs198389 genotyping attended visit 1 (aged 45–64 years; 1987–1989), with follow‐up visits occurring every 3 years (visit 2–visit 4, 1990–1999), followed by visit 5 (2011–2013). NT‐proBNP levels were measured at visits 2, 4, and 5. At visit 2, the GG genotype (frequency 18%) was associated with a 41% higher mean plasma level of NT‐proBNP compared with the AA genotype (frequency 34%), with intermediate values observed in AGs (P=4.2×10−52). The GG genotype was associated with reduced systolic blood pressure (−1.6 mm Hg, P=0.006), diastolic blood pressure (−1 mm Hg, P=0.003), antihypertension medication use (odds ratio, 0.85; 95% CI, 0.74–0.97 [P=0.02]), and hypertension (odds ratio, 0.81; 95% CI, 0.72–0.92 [P=0.002]) compared with the AA genotype with intermediate values in AGs. These relationships persisted throughout subsequent visits. After a median follow‐up of 23 years, there were 4031 deaths. With and without covariate adjustment, the GG genotype was associated with modestly lower mortality (hazard ratio, 0.86; 95% CI, 0.78–0.95), primarily reflective of cardiovascular death (hazard ratio, 0.75; 95% CI, 0.61–0.92), and increased residual lifespan of 8 months from 50 years of age (P=0.02) versus AAs. Conclusions The rs198389 G allele in the NPPB promoter is associated with elevated levels of NT‐proBNP throughout adult life, reduced blood pressure, hypertension and cardiovascular mortality, and increased lifespan.
The fate of HDL particles in vivo after SR-BI-mediated selective lipid uptake Published, JLR Papers in Press, August 16, 2002. DOI 10.1194/jlr.M200173-JLR200

Scavenger receptor class B type I (SR-BI) delivers cholesterol ester from HDL to cells via a selective uptake mechanism, whereby lipid is transferred from the core of the particle without concomitant degradation of the protein moiety. The precise metabolic fate of HDL particles after selective lipid uptake is not known. To characterize SR-BI-mediated HDL processing in vivo, we expressed high levels of this receptor in livers of apoA-I−/− mice by adenoviral vector gene transfer, and then injected the mice with a bolus of human HDL2 traced with 125I-dilactitol tyramine. HDL recovered from apoA-I−/− mice over-expressing SR-BI was significantly smaller than HDL recovered from control mice as measured by non-denaturing gel electrophoresis. When injected into C57BL/6 mice, these HDL “remnants” were rapidly converted to HDL2-sized lipoprotein particles, and were cleared from the plasma at a rate similar to HDL2. In assays in cultured cells, HDL remnants did not stimulate ATP-binding cassette transporter A1-dependent cholesterol efflux. When mixed with mouse plasma ex vivo, HDL remnants rapidly converted to larger HDL particles. These studies identify a previously ill-defined pathway in HDL metabolism, whereby SR-BI generates small, dense HDL particles that are rapidly remodeled in plasma. This remodeling pathway may represent a process that is important in determining the rate of apoA-I catabolism and HDL-mediated reverse cholesterol transport.
Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3

Rational drug design is predicated on knowledge of the three-dimensional structure of the protein−ligand complex and the thermodynamics of ligand binding. Despite the fundamental importance of both enthalpy and entropy in driving ligand binding, the role of conformational entropy is rarely addressed in drug design. In this work, we have probed the conformational entropy and its relative contribution to the free energy of ligand binding to the carbohydrate recognition domain of galectin-3. Using a combination of NMR spectroscopy, isothermal titration calorimetry, and X-ray crystallography, we characterized the binding of three ligands with dissociation constants ranging over 2 orders of magnitude. 15N and 2H spin relaxation measurements showed that the protein backbone and side chains respond to ligand binding by increased conformational fluctuations, on average, that differ among the three ligand-bound states. Variability in the response to ligand binding is prominent in the hydrophobic core, where a distal cluster of methyl groups becomes more rigid, whereas methyl groups closer to the binding site become more flexible. The results reveal an intricate interplay between structure and conformational fluctuations in the different complexes that fine-tunes the affinity. The estimated change in conformational entropy is comparable in magnitude to the binding enthalpy, demonstrating that it contributes favorably and significantly to ligand binding. We speculate that the relatively weak inherent protein−carbohydrate interactions and limited hydrophobic effect associated with oligosaccharide binding might have exerted evolutionary pressure on carbohydrate-binding proteins to increase the affinity by means of conformational entropy.
Computer-Assisted Composition at IRCAM: From PatchWork to OpenMusic

In recent years, IRCAM has been exploring and developing software for computer-assisted composition (CAC). These software packages allow composers and musicologists to formalize and experiment with the structures and dynamics of musical languages. The Formes program (Rodet and Cointe 1984), although primarily devoted to the control of sound synthesis, was really a compositional environment with a high-level object-oriented architecture. The Crime environment (Assayag, Castellengo, and Malherbe 1985; Amiot, Assayag, Malherbe, and Riotte 1986) was the first attempt at IRCAM to realize a general CAC environment where the user could define and control abstract musical formalisms. Francis Courtot developed CARLA as an attempt to use a visual programming interface to a Prolog-based logic-programming system (Balaban, Ebcioglu, and Laske 1992). The development of the PatchWork environment, by M. Laurson, J. Duthen, and C. Rueda (Laurson and Duthen 1989; Laurson 1996), was the next stage in the development of CAC programs at IRCAM. The combination of programming simplicity and a highly visual interface in a personal computing concept created an infatuation with PatchWork among European composers with highly diverse musical and aesthetic backgrounds, including Antoine Bonnet, Michel Fano, Brian Ferneyhough, Gerard Grisey, Paavo Heininen, Magnus Lindberg, Claudy Malherbe, Tristan Murail, Kaija Saariaho, and many others. OpenMusic, designed by G. Assayag and C. Agon (Assayag, Agon, Fineberg, and Hanappe 1997; Agon, Assayag, Delerue, and Rueda 1998), is the most recent IRCAM CAC environment. It is a visual interface to CLOS, the Common Lisp Object System (Steele 1990). Aside from being a superset of PatchWork, it opens new territories by allowing the composer to visually design sophisticated musical object classes. It introduces the maquette concept, which enables high-level control of musical material over time, and it revises the PatchWork visual language in a modern way.
Duality Between Prefetching and Queued Writingwith Applications to Integrated Caching and Prefetchingand to External

Parallel disks promise to be a cost eeective means for achieving high bandwidth in applications involving massive data sets, but algorithms for parallel disks can be diicult to devise. To combat this problem, we deene a useful and natural duality between writing to parallel disks and the seemingly more diicult problem of prefetching. We explore this duality for applications involving read-once accesses using parallel disks. We get a simple linear time algorithm for computing optimal prefetch schedules and analyze the eeciency of the resulting schedules for randomly placed data and for arbitrary interleaved accesses to striped sequences. Duality also provides an optimal schedule for the integrated caching and prefetching problem, in which blocks can be accessed multiple times. Another application of this duality gives us the rst external sorting sorting algorithms that are provably optimal in an asymptotic sense, in which we take into consideration the constant factors. One of these algorithms is a simple and practical variant of multiway merge sort, addressing a question that has been open for some time.
Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi

Significance The WOPR-domain family of transcriptional regulators is deeply conserved in the fungal kingdom where the members function as master transcriptional regulators of cell morphology and pathogenesis. Despite the critical biological roles of WOPR-domain proteins, previous bioinformatic and structural prediction did not provide any significant matches between these proteins and any other type of protein. We describe a 2.6-Å–resolution structure of a WOPR domain in complex with its preferred DNA sequence. We also describe a set of biochemical experiments that confirms and rationalizes the importance of the protein–DNA contacts observed in the structure. Based on the structure, we conclude that the WOPR domain represents a new family of DNA-binding proteins, one with key roles for fungal morphogenesis and pathogenesis. WOPR-domain proteins are found throughout the fungal kingdom where they function as master regulators of cell morphology and pathogenesis. Genetic and biochemical experiments previously demonstrated that these proteins bind to specific DNA sequences and thereby regulate transcription. However, their primary sequence showed no relationship to any known DNA-binding domain, and the basis for their ability to recognize DNA sequences remained unknown. Here, we describe the 2.6-Å crystal structure of a WOPR domain in complex with its preferred DNA sequence. The structure reveals that two highly conserved regions, separated by an unconserved linker, form an interdigitated β-sheet that is tilted into the major groove of DNA. Although the main interaction surface is in the major groove, the highest-affinity interactions occur in the minor groove, primarily through a deeply penetrating arginine residue. The structure reveals a new, unanticipated mechanism by which proteins can recognize specific sequences of DNA.
Trends in Citations to Books on Epidemiological and Statistical Methods in the Biomedical Literature

Background There are no analyses of citations to books on epidemiological and statistical methods in the biomedical literature. Such analyses may shed light on how concepts and methods changed while biomedical research evolved. Our aim was to analyze the number and time trends of citations received from biomedical articles by books on epidemiological and statistical methods, and related disciplines. Methods and Findings The data source was the Web of Science. The study books were published between 1957 and 2010. The first year of publication of the citing articles was 1945. We identified 125 books that received at least 25 citations. Books first published in 1980–1989 had the highest total and median number of citations per year. Nine of the 10 most cited texts focused on statistical methods. Hosmer & Lemeshow's Applied logistic regression received the highest number of citations and highest average annual rate. It was followed by books by Fleiss, Armitage, et al., Rothman, et al., and Kalbfleisch and Prentice. Fifth in citations per year was Sackett, et al., Evidence-based medicine. The rise of multivariate methods, clinical epidemiology, or nutritional epidemiology was reflected in the citation trends. Educational textbooks, practice-oriented books, books on epidemiological substantive knowledge, and on theory and health policies were much less cited. None of the 25 top-cited books had the theoretical or sociopolitical scope of works by Cochrane, McKeown, Rose, or Morris. Conclusions Books were mainly cited to reference methods. Books first published in the 1980s continue to be most influential. Older books on theory and policies were rooted in societal and general medical concerns, while the most modern books are almost purely on methods.
International Journal of Information Management

Recently, profound technological changes and greater customer demand have triggered a sudden increase in e-service innovations. However, little research so far has explored the capabilities needed in order to innovate and implement e-service solutions. The purpose of this study is to investigate the antecedents of e-service innovation and its impact on a ﬁrm’s performance outcomes of value cocreation and ﬁrm value. The main research method of this study is a quantitative survey and analysis. Our analysis of 119 ﬁnancial service ﬁrms in Taiwan shows that the impact of e-service innovation on ﬁrm outcomes begins with e-service and cooperation capabilities, and that the complementarity between these factors positively inﬂuences e-service innovation. Furthermore, e-service innovation exerts a positive effect on value cocreation, thereby improving ﬁrm value.