Miracle-dz/UniFAR-FTUs huggingface dataset:
Personality Correlates of Depressive Style in Autobiographies of Creative Achievers

This study compared neurotic and depressive personality characteristics in creative achievers versus eminent but non-creative achievers. Forty-eight subjects' (25 men, 23 women) autobiographies were assessed by trained raters on personality using the California Q-Set. Creative achievers included literary and visual artists whereas the control group consisted of political, military and social leaders. The Q-Set ratings were used to assess the five factors of personality (neuroticism, extroversion, openness to experience, agreeableness and conscientiousness). Neuroticism was further divided into subscales that assessed depressive style, impulsivity and anxiety. Results showed that creative achievers were rated significantly higher than controls on general neuroticism, as well as on depressive style and impulsivity. Creative achievers did not differ from controls in anxiety. It was also found that creative achievers were rated significantly higher than controls on openness to experience and agreeableness, but lower on conscientiousness. None of the effects for creativity was affected by subjects' sex.
The Value of an Allotment Group for Refugees

Introduction: Refugees experience a number of difficulties when settling in the United Kingdom and may be faced with occupational injustice due to their restricted occupational engagement. This study explores the value of an allotment group for refugees of working age, aiming to explore the role of horticulture and the social environment on health, wellbeing and social inclusion. Method: This was an exploratory study using qualitative methodology based on ethnographic principles. Data collection included observation of the group, semi-structured interviews with five participants, with four of these participants also taking part in photo-elicitation interviews. Data analysis involved using a ‘framework’ approach to produce three themes and associated sub-themes. Findings: Analysis identified firstly gardening as a meaningful activity; secondly, the importance of the social environment and, lastly, the value of occupational engagement for refugees. Further theoretical analysis led to the conclusion that these themes linked to the dimensions of occupation: doing, being, belonging and becoming. Conclusion: The findings identify how occupational engagement can have a positive impact on the health and wellbeing of refugees, specifically with the use of social and therapeutic horticulture.
Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons

Arginine vasopressin (AVP) is secreted via exocytosis; however, the precise molecular mechanism underlying the exocytosis of AVP remains to be elucidated. To better understand the mechanisms of AVP secretion, in our study we have identified proteins that bind with a 25 kDa synaptosomal-associated protein (SNAP25). SNAP25 plays a crucial role in exocytosis, in the posterior pituitary. Embryonic stem (ES) cell-derived AVP neurons were established to investigate the functions of the identified proteins. Using glutathione S-transferase (GST)-pulldown assays and proteomic analyses, we identified tomosyn-1 (syntaxin-binding protein 5) as a SNAP25-binding protein in the posterior pituitary. Coimmunoprecipitation assays indicated that tomosyn formed N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes with SNAP25 and syntaxin1. Immunohistochemistry showed that tomosyn localized to the posterior pituitary. Mouse ES cells self-differentiated into AVP neurons (mES-AVP) that expressed tomosyn and two transmembrane SNARE proteins, including SNAP25 and syntaxin1. KCl increased AVP secretion in mES-AVP, and overexpression of tomosyn-1 reduced KCl-stimulated AVP secretion. Downregulation of tomosyn-1 with siRNA increased KCl-stimulated AVP secretion. These results suggested that tomosyn-1 negatively regulated AVP secretion in mES-AVP and further suggest the possibility of using mES-AVP culture systems to evaluate the role of synaptic proteins from AVP neurons.
Visualization and Measurement of ATP Levels in Living Cells Replicating Hepatitis C Virus Genome RNA

Adenosine 5′-triphosphate (ATP) is the primary energy currency of all living organisms and participates in a variety of cellular processes. Although ATP requirements during viral lifecycles have been examined in a number of studies, a method by which ATP production can be monitored in real-time, and by which ATP can be quantified in individual cells and subcellular compartments, is lacking, thereby hindering studies aimed at elucidating the precise mechanisms by which viral replication energized by ATP is controlled. In this study, we investigated the fluctuation and distribution of ATP in cells during RNA replication of the hepatitis C virus (HCV), a member of the Flaviviridae family. We demonstrated that cells involved in viral RNA replication actively consumed ATP, thereby reducing cytoplasmic ATP levels. Subsequently, a method to measure ATP levels at putative subcellular sites of HCV RNA replication in living cells was developed by introducing a recently-established Förster resonance energy transfer (FRET)-based ATP indicator, called ATeam, into the NS5A coding region of the HCV replicon. Using this method, we were able to observe the formation of ATP-enriched dot-like structures, which co-localize with non-structural viral proteins, within the cytoplasm of HCV-replicating cells but not in non-replicating cells. The obtained FRET signals allowed us to estimate ATP concentrations within HCV replicating cells as ∼5 mM at possible replicating sites and ∼1 mM at peripheral sites that did not appear to be involved in HCV replication. In contrast, cytoplasmic ATP levels in non-replicating Huh-7 cells were estimated as ∼2 mM. To our knowledge, this is the first study to demonstrate changes in ATP concentration within cells during replication of the HCV genome and increased ATP levels at distinct sites within replicating cells. ATeam may be a powerful tool for the study of energy metabolism during replication of the viral genome.
Tolerance for Pain, Extraversion and Neuroticism

It may be deduced from Eysenck's (1957, 1960a) theory of personality that pain tolerance should be positively related to extraversion (E) and negdtively to neuroticism (N). Extraverted Ss are postulated to develop inhibition/ satiation more quickly, and dissipate it more slowly; prolonged pain sensations should thus be inhibited more quickly and strongly in extraverts, leading to diminished pain sensations. Furthermore, as Beecher (1959) has pointed out, physiological pain sensations are always accompanied by the app7ehe? zsion of fatare pain, which may be conceived as a conditioned fear (anxiety) response which sumrnates with the physiological pain. Extraverts are posited to condition less well, and would therefore not develop this component of the total pain to the same extent as introverts. The prediction relating to N is perhaps less secure; it rests on the assumption that the strength of the autonomic reaction to pain stimulation would be likely to be related directly to N, which is conceived of in terms of autonomic lability (Eysenck, 1960b). This autonomic reaction would be expected to summate with the physiological pain due to the stimulus. Thirry volunteer university students, the experimental group, were given the Maudsley Personality Inventory as a measure of E and N (Eysenck, 1959), as well as the Rotating Spiral After-effect test which is an objective measure of E (Eysenck, 1960a). Ss' foreheads were blackened with India ink, and they were then subjected to heat stimulation by a thermo-stimulator modelled after the description given by Hardy, Wolff, and Goodell ( 1952 ). The radiation intensity was set at 166 w, and Ss were instructed to report the onset of pain, which is usually characterized by a sharp prick following a sensation of warmth. They were then to try to tolerate the pain for as long as they could. Pain tolerance was the number of seconds from the first report of pain to the final withdrawal. All Ss reported pain within 3 to 5 sec. after exposure. There appears to be a habituation effect after about 12 sec. of pain, such that, if pain could be tolerated for this long, Ss reported that they felt it could be endured indefinitely. Five Ss tolerated the pain for 60 sec. , after which the trial was terminated. A time limit of 20 sec. was finally set because of blisters which began to develop after about 8 sec. exposure. When Ss are divided into three groups of 10 according to their E scores, their pain tolerance decreases from 17.2 (high E) through 9.3 to 5.6 (low E); 'We are indebted to the Society for Research in Human Ecology for a grant which made this study possible.
Politics, research and the natural environment: the lifeworlds of water-based sport and recreation in Wales

While the politics of recreational access to the natural environment has long been associated with walking, there is growing recognition that other forms of access can, in political terms, be more problematic. One such case is recreational access to inland waters in England and Wales, which has long been dominated by the oppositional politics of anglers and canoeists. Recognising the limitations of conventional evidence-based approaches to policy-making, this paper offers a phenomenological perspective on the politics of water related recreation, suggesting that approaches to the ‘solution’ of access problems may be found by understanding better the lifeworlds of those involved in the debates. This is illustrated by reference to a recent official inquiry into access along inland waters in Wales.
Frozen on ice: rendering frost and ice on Frozen

classroom use is granted without fee provided that copies are not made or distributed for commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for third-party components of this work must be honored. For all other uses, contact the Owner/Author. SIGGRAPH 2014, August 10 – 14, 2014, Vancouver, British Columbia, Canada. 2014 Copyright held by the Owner/Author. ACM 978-1-4503-2960-6/14/08 Frozen on Ice: Rendering Frost and Ice on Frozen
Performance Evaluation of III–V Nanowire Transistors

III–V nanowire (NW) transistors are an emerging technology with the prospect of high performance and low power dissipation. Performance evaluations of these devices, however, have focused mostly on the intrinsic properties of the NW, excluding any parasitic elements. In this paper, a III–V NW transistor architecture is investigated, based on a NW array with a realistic footprint. Based on scaling rules for the structural parameters, 3-D representations of the transistor are generated, and the parasitic capacitances are calculated. A complete optimization of the structure is performed based on the RF performance metrics <formula formulatype="inline"><tex Notation="TeX"> $f_{T}$</tex></formula> and <formula formulatype="inline"><tex Notation="TeX">$f_{\max}$</tex></formula>, employing intrinsic transistor data combined with calculated parasitic capacitances and resistances. The result is a roadmap of optimized transistor structures for a set of technology nodes, with gate lengths down to the 10-nm-length scale. For each technology node, the performance is predicted, promising operation in the terahertz regime. The resulting roadmap has implications as a reference both for benchmarking and for device fabrication.
Is Oprah Contagious? The Depth of Diffusion of Demand Shocks in a Product Network

Table A1 depicts comparison statistics on the matched sample versus the treatment groups for each distance. Similarly, Table A2 depicts comparison statistics on the network-based group used as a control versus the treatment groups. The variable Total25 is used to control for Amazon’s $25 shipping policy, capturing whether the sum of the price of the reviewed book and any of the books in the local network passes the $25 free shipping threshold; indegree captures the number of books directed to a focal book in the product network; local clustering measures the degree to which books in the product network tend to cluster together to create groups characterized by a their density of ties; same binding indicates whether a purchased book is of the same binding type (e.g., hardcover, paperback) as the reviewed book; sale price controls for the sales price of a purchased book; average rating captures the subjective evaluation of a book as reported by consumers; and sales rank measuring a book’s demand relative to other products.
Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8+ T cells sensitizing them to apoptotic cell death

The life‐long homeostasis of memory CD8+ T cells as well as persistent viral infections have been shown to facilitate the accumulation of highly differentiated CD8+CD28− T cells, a phenomenon that has been associated with an impaired immune function in humans. However, the molecular mechanisms regulating homeostasis of CD8+CD28− T cells have not yet been elucidated. In this study, we demonstrate that the miR‐23∼24∼27 cluster is up‐regulated during post‐thymic CD8+ T‐cell differentiation in humans. The increased expression of miR‐24 in CD8+CD28− T cells is associated with decreased expression of the histone variant H2AX, a protein that plays a key role in the DNA damage response (DDR). Following treatment with the classic chemotherapeutic agent etoposide, a topoisomerase II inhibitor, apoptosis was increased in CD8+CD28− when compared to CD8+CD28+ T cells and correlated with an impaired DDR in this cell type. The reduced capacity of CD8+CD28− T cell to repair DNA was characterized by the automated fluorimetric analysis of DNA unwinding (FADU) assay as well as by decreased phosphorylation of H2AX at Ser139, of ATM at Ser1981, and of p53 at Ser15. Interleukin (IL)‐15 could prevent etoposide‐mediated apoptosis of CD8+CD28− T cells, suggesting a role for IL‐15 in the survival and the age‐dependent accumulation of CD8+CD28− T cells in humans.
Fault Localization Based on Dynamic Slicing and Hitting-Set Computation

Slicing is an effective method for focusing on relevant parts of a program in case of a detected misbehavior. Its application to fault localization alone and in combination with other methods has been reported. In this paper we combine dynamic slicing with model-based diagnosis, a method for fault localization, which originates from Artificial Intelligence. In particular, we show how diagnosis, i.e., root causes, can be extracted from the slices for erroneous variables detected when executing a program on a test suite. We use these diagnoses for computing fault probabilities of statements that give additional information to the user. Moreover, we present an empirical study based on our implementation JSDiagnosis and a set of Java programs of various size from 40 to more than 1,000 lines of code.
Goal-Directed Pedestrian Prediction

Recent advances in road safety have lead to a constant decline of injured traffic participants in Europe per year. Still, the number of injured pedestrians remains nearly constant. As a countermeasure, active pedestrian safety is the focus of current research, for which accurate pedestrian prediction is a prerequisite. In this scope, we propose a method for dynamics-and environment-based pedestrian prediction. We introduce the pedestrian's destination as a latent variable and thus convert the prediction problem into a planning problem. The planning is executed based on the current dynamics of the pedestrian. The distribution over the destinations is modeled using a Particle Filter. Experimental results show a significant improvement over existing approaches such as Kalman Filters.
Significance of grunting respirations in infants admitted to a well-baby nursery.

OBJECTIVES (1) To determine the frequency and duration of grunting in term and near-term newborns; (2) to determine the peripartum characteristics associated with grunting; and (3) to compare the short-term outcomes of newborns with and without grunting. DESIGN Medical record review of all newborns admitted to a well-baby nursery during a 2-month period. SETTING University well-baby nursery for term infants, with more than 2700 deliveries annually. MAIN OUTCOME MEASURES Frequency and duration of grunting, maternal and newborn clinical characteristics, clinical course, and length of stay. RESULTS Grunting respirations beginning during the first 4 hours of life were recorded for 81 (17.4%) of 466 newborns. Fifty-five (68%) stopped grunting within 30 minutes of birth, 69 (85%) by 1 hour, and 75 (93%) by 2 hours. More mothers of grunting infants received intrapartum antibiotics than mothers of nongrunters (33% vs 20%; P =.03). More grunting infants than nongrunters received bag and mask resuscitation (15% vs 5%; P =.01). More chest radiographs, blood cell counts, and blood cultures were ordered for grunting infants, and antibiotics were more often given to grunting than nongrunting infants (11.1% vs 4.6%; P =.04). Grunters' length of stay exceeded that of nongrunters (72 vs 55 hours; P =.01), but only 3 were transferred to a neonatal intensive care unit. CONCLUSIONS All grunting infants should be carefully observed, but because nearly all otherwise healthy term or near-term infants will stop grunting and have a benign course, other interventions can be postponed for 1 or 2 hours to give the newborn a chance to stop grunting or show other signs of respiratory illness.
Perchlorate in Martian Soil: Evidence and Implications

K. Gospodinova, J. Kapit, S. P. Kounaves , D. W. Ming, R. C. Quinn, S. J. West , S.M. M Young, and the Phoenix Team. Jet Propulsion Laboratory, California Institute of Technology (michael.h.hecht@jpl.nasa.gov), Department of Earth Sciences, University of Bristol , UK, 3 Lockheed Martin, Denver, CO (ret.), Department of Chemistry, Tufts University, Medford, MA , NASA Johnson Space Center, Houston, TX, SETI Institute, Mountain View, CA, Invensys Process Systems, Foxboro, MA
Parental attachment and romantic relationships in emerging adults: The role of emotional regulation processes

This cross-sectional study involving a sample of Portuguese college students examined whether parental attachment bonds are related to quality of romantic attachment and whether emotional regulation processes mediate these links. One hundred and seventy college undergraduates completed measures of parental attachment bonds, emotional regulation and a measure of romantic attachment at the beginning of their freshman year. Structural Equations Modeling analyses demonstrated that the quality of parental attachment predicted different patterns of emotional regulation, which in turn predicted significant variability in the representations of students' relationships with intimate peers. The implications of our findings on counseling college students in distressed relationships are discussed.
Changing the Nature and Conditions of Employment: Stimulating Critical Reflection

Building on the liberatory aspirations for management education promoted by Boyce, the authors have devised a classroom exercise to illustrate our unconscious participation in the reorganization of employment. The exercise is designed to interest students in critical theory as an approach to learning that encourages asking challenging questions of our organizations and of ourselves. It may be used as a precursor to wider discussions about what responsibilities we each have for the well-being of other human beings and how various life circumstances influence our decisions and our emotions.
Decision-making coordination in collaborative product configuration

In Software Product Lines (SPLs), product configuration is a decision-making process in which a group of stakeholders choose features for a product. Unfortunately, current configuration technology is essentially single-user-based in which user requirements are interpreted and translated into configuration decisions by a single role commonly referred to as the product manager. This process can be error-prone and time-consuming as it commonly requires back-and-forth interactions between the product manager and the stakeholders to cope with decision conflicts. In this paper, we propose an approach to Collaborative Product Configuration (CPC) that aims at providing effective support for coordinating teamwork decision-making in the context of product configuration. The approach builds on well-known concepts in the SPL arena such as feature models. The contributions of the paper include the CPC approach and the illustration of its application in a real-world product line.
Is Ignorance Bliss? Pre-service Teachers' Attitudes Toward Multicultural Education

In the United States, the number of school-aged students from diverse backgrounds is increasing, yet, according to research, the majority of teachers and those in teacher education programs continue to be predominantly Caucasian, middle class and English monolingual speakers. Studies have shown that many of those entering the field of teaching have a lack of knowledge of the experiences, needs, and resources of culturally and linguistically diverse student populations. As such, teacher preparation programs have developed and required that pre-service teachers complete a multicultural education course. This study explored the effect a multicultural education course has on pre-service teachers' attitudes about the experiences, needs, and resources of culturally and linguistically diverse student populations as well as the value they place on multicultural education. Using anonymous pre and post test surveys, we began by examining the initial attitudes of pre-service teachers' prior to taking a multicultural education course. We then studied the extent to which their attitudes changed subsequent to the instruction. The findings showed pre-service teachers' attitudes improved as they developed an increased awareness of and appreciation toward other cultures. Even with this increased awareness and appreciation of students' diverse cultures, the pre-service teachers expressed a sense of being ill equipped to teach students from diverse backgrounds. This sentiment also included a fear of being rejected by parents of minority students. Based upon the findings, implications and recommendations for program and curriculum revisions are discussed.
Analysing and enhancing the performance of associative memory architectures

This thesis investigates the way in which information about the structure of a set of training data with `natural' characteristics may be used to positively influence the design of associative memory neural network models of the Hopfield type. This is done with a view to reducing the level of connectivity in models of this type. There are three strands to this work. Firstly, an empirical evaluation of the implementation of existing theory is given. Secondly, a number of existing theories are combined to produce novel network models and training regimes. Thirdly, new strategies for constructing and training associative memories based on knowledge of the structure of the training data are proposed. The first conclusion of this work is that, under certain circumstances, performance benefits may be gained by establishing the connectivity in a non-random fashion, guided by the knowledge gained from the structure of the training data. These performance improvements exist in relation to networks in which sparse connectivity is established in a purely random manner. This dilution occurs prior to the training of the network. Secondly, it is verified that, as predicted by existing theory, targeted post-training dilution of network connectivity provides greater performance when compared with networks in which connections are removed at random. Finally, an existing tool for the analysis of the attractor performance of neural networks of this type has been modified and improved. Furthermore, a novel, comprehensive performance analysis tool is proposed.