Miracle-dz/UniFAR-FTUs huggingface dataset:
YL 4073 is a potent autophagy-stimulating antitumor agent in an in vivo model of Lewis lung carcinoma

Cancer cells activate autophagy in response to anticancer therapies. Autophagy induction is a promising therapeutic approach to treat cancer. In a previous study, YL4073 inhibited the growth of liver cancer and induced liver cancer cell apoptosis. Here, we demonstrated the anticancer activity and specific mechanisms of YL4073 in Lewis lung carcinoma LL/2 cells. Our results show that YL4073-induced autophagy was followed by apoptotic cell death. The anticancer and autophagy stimulating efficacy was confirmed by several factors, including the appearance of autophagic vacuoles, formation of acidic vesicular organelles, recruitment of microtubule-associated protein 1 light chain 3 II (LC3-II) to the autophagosomes, conversion and cleavage of LC3-I to LC3-II, upregulation of Beclin 1 expression, and formation of the Atg12-Atg5 conjugate in LL/2 cells after YL4073 treatment for 24 or 48 h. Furthermore, P53 activation and p-histone H3 phosphorylation occurred after cell exposure to YL4073 for 48 h, suggesting that cell apoptosis had occurred. Pharmacological inhibition of autophagy using 3-methyladenine increased cell apoptosis. Molecular level studies revealed that YL4073 inhibited survival signalling by blocking the activation of Akt and mTOR phosphorylation and reduced the expression of p-mTOR downstream targets for phosphorylation, including p70S6K, p-TSC, p-MAPK, and p-AMPK. This suggests that the Akt/mTOR/p70S6K and TSC/MAPK/AMPK pathways are involved in the effects of YL4073 treatment in LL/2 cells. In addition, YL4073 significantly inhibited LL/2 tumor growth and induced apoptosis in vivo. These data suggest that YL4073 has a significant anticancer effect, with a pathway-specific mechanism of autophagy both in vitro and in vivo.
Towards metamodel support for variability and traceability in software product lines

In Software Product Lines (SPL), where a greater variety of products are derived from a common platform and constantly changed and evolved, it is important to manage the SPL variability and the traceability among its artifacts. This paper presents a metamodel which aims to coordinate SPL activities, by managing different SPL phases and their responsibles, and to maintain the traceability and variability among different artifacts. The metamodel was built for a SPL project in a private company working in the medical information management domain, which includes four products encompassing 102 different modules and 840 features. The metamodel is divided into five sub-models: project and risk management, scoping, requirements and testing. It is represented in the UML notation. Organizations using this metamodel as basis for their approaches, can easily understand the relationships between the SPL assets, communicate to the stakeholders, and facilitate the evolution and maintenance of the SPL. The metamodel can also be adapted to the single system development context.
On the analysis of copy‐number variations in genome‐wide association studies: a translation of the family‐based association test

Though there is an increasing support for an important contribution of copy number variation (CNV) to the genetic architecture of complex disease, few methods have been developed for the analysis of such variation in the context of genetic association studies. In this paper, we propose a generalization of family‐based association tests (FBATs) to allow for the analysis of CNVs at a genome‐wide level. We translate the popular FBAT approach so that, instead of genotypes, raw intensity values that reflect copy number are used directly in the test statistic, thereby bypassing the need for a CNV genotyping algorithm. Moreover, both inherited and de novo CNVs can be analyzed without any prior knowledge about the type of CNV, making it easily applicable to large‐scale association studies. All robustness properties of the genotype FBAT approach are maintained and all previously developed FBAT extensions, including FBATs for time‐to‐onset, multivariate FBATs, and FBAT‐testing strategies, can be directly transferred to the analysis of CNVs. Using simulation studies, we evaluate the power and the robustness of the new approach. Furthermore, for those CNVs that can be genotyped, we compare FBATs based on genotype calls with FBATs that are directly based on the intensity data. An application to one of the first CNV genome‐wide‐association studies of asthma identifies a very plausible candidate gene. A software implementation of the approach is freely available at http://www.hsph. harvard.edu/research/iuliana‐ionita/software. The approach has also been completely integrated in the PBAT software package. Genet. Epidemiol. © 2008 Wiley‐Liss, Inc.
TSTM: A two-stage tone mapper combining visual adaptation and local contrast enhancement

We present TSTM, a Two-Stage Tone Mapping model for high dynamic range (HDR) images inspired by two basic human visual f eatures: visual adaptation and local contrast enhancement. T he first property is usually implemented with the so-called Naka-Ru shton equation, a rational transformation which permits to prope ly compress the range of the input HDR image. We provide a fundamental extension of this formula, emphasizing the role played b y contrast perception. The second stage consists in a variationa l method able to perform local contrast enhancement consistent with human vision phenomenology. TSTM has computational complexi ty O(N log N), beingN the number of input pixels, and it is free from halos and artifacts. Tests and comparisons with other t one mapping algorithms are also provided and commented. CR Categories: I.4. 3 [Image Processing]: Enhancement—; I.4. 8 [Scene Analysis]: Range Data— [I.2. 10]: Vision and Sc ene Understanding—Intensity, color, photometry and threshol ding
Developmental Verbal Dyspraxia: A Clinical Perspective

The charts of 40 children ages 4;0 through 9;11 who had articulation disorders were reviewed for symptoms of developmental verbal dyspraxia (DVD). Abnormalities of syllable production such as inaccuracy, reduced rate and poor sequencing were considered necessary to diagnose DVD. Four of the other eight symptoms needed to be present to be sufficient for DVD diagnosis. Three groups of children were identified. Group 1 had little or no syllable production problems; Group 2 had moderate syallable production problems; Group 3 had severe syllable production problems. The 15 children with severe abnormalities in syllable production (group 3) were much more likely to have DVD symptoms than children with little or no syllable production problems (group 1). Non-verbal oral motor problems were present in only 9% of group 1 children and in 60% of group 3 children. For delayed onset of sentence formulation the percents were 9% and 47%; for severe articulation disorders 9% and 40%; for soft neurological signs 18% and 3.
Reconciling Inconsistencies Between Package-extended Ontology Modules

Construction of ontologies in specific domains (e.g., molecular biology, electronic commerce), is invariably a collaborative activity that requires incorporation of independently generated ontology fragments or ontology modules, and hence reconciliation of inconsistencies among ontology modules. We investigate an approch to reconciling the inconsistencies among ontologies using defeasible axioms. In this framework, each ontology module can be viewed as an internally consistent unit (called a package) with well-specified access interfaces. Multiple ontology modules or packages can be combined to obtain larger ontologies. Inconsistencies between ontology modules are handled using defeasible axioms (an axiom in one package can defeat one or more axioms from other packages), thereby making the resulting composite ontology internally consistent. The resulting framework supports collaborative ontology construction as well as integration of preexisting ontologies.
Science funding and science policy: Big data as a tool for supporting the research funding process

UberResearch pursues a comprehensive approach to big and small data to aid science funders in operations and analysis. We seek to consolidate global award data and funders’ internal data, with a focus on data harmonization, natural language processing and disambiguation. In this article, firstly, I give a definition and some examples of big data. Next, I look at the relevance of big data in science funding. Third, I look at important challenges in the science funding process. Finally, I turn to big data solutions and the UberResearch approach in implementing them.
Who Gets Hired? The Importance of Finding an Open Slot

A model of hiring into posted job slots suggests hiring is based on comparative advantage: being hired depends not only on one’s own skill but also on the skills of other applicants. The model has numerous implications. First, bumping of applicants occurs when one job-seeker is slotted into a lower paying job by another applicant who is more skilled. Second, less able workers are more likely to be unemployed because they are bumped. Third, vacancies are higher for harder to fill skilled jobs. Fourth, some workers are over-qualified for their jobs whereas others are under-qualified. These implications are borne out using four different data sets.
Postgraduate students learning about research: exploring the attitudes of social work and mental health students in an English university setting.

We discuss an ongoing pedagogic initiative and research project exploring how postgraduates undertaking social work or mental health educational programmes in one UK university since 2007 responded to learning about research methods during a year-long module. Few studies have looked specifically at postgraduate students’ attitudes towards research / research methods although previous work considered undergraduate students’ attitudes or research methods training for social work or health studies students. We note from previous research that students may express anxiety when learning about research, particularly quantitative methods. Using an existing validated rating scale with 5 subscales (Papanastasiou, 2005), we explored student attitudes prior to taking a research module and the possible significance of gender, professional group and status on course (college or employment based). We report initial findings from two student cohorts (2007-8 & 2008-9) comprising 105 social work + dual diagnosis (mental health) masters students. Project data was then used by students to complete a quantitative assignment as part of module assessment. Results showed these students had a ‘positive’ attitude towards research pre-module; this was generally maintained but did not increase post-module. Student cohorts were rated as having overall research ‘anxiety’ pre-module; this lessened post-module although the change was not statistically significant. A significant change (decrease) in ‘usefulness to career’ subscale was recorded post-module. We consider the factors that could have impacted on these research findings such as reduced follow up sample sizes ; but report how combining a pedagogic initiative with a research project offers opportunities to explore this complex area in more depth and with positive outcomes for student learning.
Lamotrigine Treatment for Affective Instability in Adolescents With Borderline Personality Disorder

Patients with BPD are characterized by a pervasive pattern of instability in affect regulation, impulse control, interpersonal relationships, and self-image. The efficacy of fluvoxamine and lamotrigine for affective instability in patients with BPD has been shown in controlled studies. However, no study has evaluated the effectiveness and safety of lamotrigine for treating irritability in adolescent patients with BPD in Japan. Here, we report the case of a patient with BPD whose condition improved after lamotrigine administration. Lamotrigine could be effective and safe for treating BPD-associated affective instability. However, large-scale controlled studies are needed to confirm our findings.
Control information description model and processing mechanism in the trustworthy and controllable network

Traditional networks are surprisingly fragile and difficult to manage. The problem can partly be attributed to the exposition of too many details of the controlled objects leading to the deluge of complexity in control plane, and the absence of network-wide views leading to the blindness of network management. With these problems, this paper decomposes the necessary network management information into three parts: the basic information, the cross-layer association, and global information. And a new controlled object description model is presented in the trustworthy and controllable network control architecture which separates the functionality of control and management of network form the data plane of IP network, and constructs the formal control and management plane of IP network. The new model identifies and abstracts the controlled objects with object-oriented approach. Based on this model, a cross-layer database is built to store the different layer control objects and to present cross-layer association view, a processing mechanism to process the original information is presented for global network state view, and a control plane is constructed to realize network control. The control information description model restricts the complexity of the controlled objects to their own implementation by abstraction, and alleviates the difficulty of network management. The cross-layer association view and the global network state view composes the network-wide views. The network-wide views realize the visibility and improve the manageability of network. Finally, we present 3 examples to indicate that the model alleviates the complexity of configuration management.
Human mitochondrial transfer RNAs: Role of pathogenic mutation in disease

The human mitochondrial genome encodes 13 proteins. All are subunits of the respiratory chain complexes involved in energy metabolism. These proteins are translated by a set of 22 mitochondrial transfer RNAs (tRNAs) that are required for codon reading. Human mitochondrial tRNA genes are hotspots for pathogenic mutations and have attracted interest over the last two decades with the rapid discovery of point mutations associated with a vast array of neuromuscular disorders and diverse clinical phenotypes. In this review, we use a scoring system to determine the pathogenicity of the mutations and summarize the current knowledge of structure–function relationships of these mutant tRNAs. We also provide readers with an overview of a large variety of mechanisms by which mutations may affect the mitochondrial translation machinery and cause disease. Muscle Nerve, 2007
A New Query Suggestion Algorithm for Taxonomy-based Search Engines

The objective of this work is the realization of an algorithm to provide a query suggestion feature in order to support the search engine of a commercial web site. Starting from web server logs, our solution creates a model analyzing the queries submitted by the users. Given a submitted query, the system searches the most adequate queries to suggest. Our method implements an already known session based proposal enriching it by exploiting specific information available in the current context: the category the user is browsing on the web site and a solution to overcome the limits of a pure session based approach considering also similarity between queries. Quantitative and qualitative experiments show that the proposed model is suitable in terms of resources employed and user’s satisfaction degree.
Languaged and non-languaged ways of knowing in counselling and psychotherapy

Examining the extent to which the lived, embodied experience can be worded, a study integrating artistic research methodologies of narrating and perceptual practices was designed. The combined use of writing and moving showed the importance of non-languaged ways of knowing, building on the idea of an embodied cognition and the embodied mind, as recently proposed by philosophy. Artistic research methodologies that include embodied perceptual practices are suggested to be used more widely in counselling and psychotherapy research. Crossing over modalities and thus brain hemispheres, they allow access to valuable – at times unconscious – material from the clinical work, accessing the knowledge of the body, beyond words.
Navigating change into the new millennium: themes and issues for the learning organization

Suggests that the end of the twentieth century may witness the end of modernity and that the post‐modern world of organizations will be driven by a new set of expectations. On the one hand certain trends are discernible as a result of globalization and on the other internal debates within Organizational Development will reshape intervention strategies through organizational learning and Human Resource Development.
Overview of Audio Watermarking Techniques

— With the increasing usage of digital multimedia, the protection of intellectual property rights problem has become a very important issue. Digital watermarking is now drawing attention as a new method of protecting multimedia content from unauthorized copying. In this paper, need for audio watermarking along with its important properties is explained. The paper also brings to view works done by various on digital audio watermarking.
On : Home Automation System For Disabled People Using BCI

The development in home automation is moving forward towards the future in creating the ideal smart homes environment. Optionally, home automation system design also been develop for certain situation which for those who need a special attention such as old age person, sick patients, and handicapped person. A brain–computer interface (BCI), often called a mind-machine interface (MMI), or sometimes called a brain–machine interface (BMI), it is a direct communication pathway between the brain and an external device. A brain–computer interface (BCI) is a device that enables severely disabled people to communicate and interact with their environments using their brain waves. Most research investigating BCI in humans has used scalp-recorded electroencephalography or intracranial electrocorticography. The use of brain signals obtained directly from stereotactic depth electrodes to control a BCI has not previously been explored. In this paper, we present a smart home automation system using brain–computer interface. The scope of this research work will include the control and monitoring system for home appliances from Graphical User Interface (GUI) using brain–computer interface that use an input source and being control wirelessly. The research methodology involved is application of knowledge in the field of radio frequency communication, microcontroller and computer programming. Finally, the result will be observed and analyze to obtain better solution in the future.
Adaptive multi-model CMAC-based supervisory control for uncertain MIMO systems

In this paper, an adaptive multi-model CMAC-based controller (AMCBC) in conjunction with a supervisory controller is developed for uncertain nonlinear MIMO systems. AMCBC is a kind of adaptive feedback linearizing controller where nonlinearity terms are approximated with multiple CMAC neural networks. With the help of a supervisory controller, the resulting close-loop system is globally stable. The proposed control system is applied to control a robotic manipulators, where some varying tasks are repeated but information on the load is not defined; it is unknown and varying. It is shown how the proposed controller is effective because of its capability to memorize the control skill for each task using CMAC neural network. Simulation results demonstrate the effectiveness of the proposed control scheme for the robotic manipulators
On modal subspaces of extended Alamouti space-time block codes

In this paper, two fundamental subspace invariances of quasiorthogonal space-time block codes recursively derived from the Alamouti code (Jafarkhani codes, extended Alamouti codes) are proven: (i) an eigenbasis of the code word distance matrices can be found which is invariant with respect to the chosen modulation alphabet and (ii) the eigenspaces of the virtual channel matrices are invariant with respect to the channel state realization. These subspace invariances lead to important conclusions: The subspace invariance (i) enables efficient transmission schemes with very small amount of channel state feedback. As a corollary of (ii), an extremely tight analytical bound for the bit error rate can be obtained.
Craving the Scoop: An Examination of Highly Identified Fans’ Utilization of Subscription-Based College-Recruiting Networks

The growing popularity of specialized college-recruiting networks has provided a unique venue for sport consumers to promote and sustain their fandom. With a distinctive subscription-based offering, fans can develop camaraderie in addition to immersing themselves in information on current and future aspects of their favorite team. The purpose of this study is to examine the peculiar indulgences sought and obtained by highly identified fans through the paid use of college-recruiting networks. The current study follows up on previous quantitative explorations into the topic, employing uses and gratifications theory as a framework to analyze the underlying motivations of membership. Fifteen highly identified fans of several fbs teams were interviewed. Findings demonstrate the value of segmented information; recruiting’s impact on collective self-identity; and how utilization of interactive features of these sites provides a strong sense of community, while also allowing for vicarious participation within the scope of new media.
Rho inhibits cAMP-induced translocation of aquaporin-2 into the apical membrane of renal cells.

First published August 8, 2001; 10.1152/ajprenal.00091. 2001. -We have recently demonstrated that actin depolymerization is a prerequisite for cAMP-dependent translocation of the water channel aquaporin-2 (AQP2) into the apical membrane in AQP2-transfected renal CD8 cells (29). The Rho family of small GTPases, including Cdc42, Rac, and Rho, regulates the actin cytoskeleton. In AQP2-transfected CD8 cells, inhibition of Rho GTPases with Clostridium difficile toxin B or with C. limosum C3 fusion toxin, as well as incubation with the Rho kinase inhibitor, Y-27632, caused actin depolymerization and translocation of AQP2 in the absence of the cAMP-elevating agent forskolin. Both forskolin and C3 fusion toxin-induced AQP2 translocation were associated with a similar increase in the osmotic water permeability coefficient. Expression of constitutively active RhoA induced formation of stress fibers and abolished AQP2 translocation in response to forskolin. Cytochalasin D induced both depolymerization of F-actin and AQP2 translocation, suggesting that depolymerization of F-actin is sufficient to induce AQP2 translocation. Together, these data indicate that Rho inhibits cAMP-dependent translocation of AQP2 into the apical membrane of renal principal cells by controlling the organization of the actin cytoskeleton.
Psychotherapy Transcription Standards

Although use of psychotherapy transcripts is becoming increasingly important in psychotherapy research, large-scale collaborative work is hindered by lack of suitable transcription standards. Guidelines are presented for the transcription of discourse, such as psychotherapy sessions, for research and educational purposes. Transcripts generated by following these standards will be readable by human judges; they will also be easily submitted for computer-aided text analysis, such as formal concordance.