Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterizing the Connectivity of Railway Networks

How well stations are connected with each other is a critical performance assessment of railway systems. Network analysis is a highly intuitive and interpretable approach to characterizing the physical connectivity of railway systems. However, the physical connectivity is often limited in depicting transportation network dynamics due to the lack of traffic flow information. This paper first comprehensively reviews the physical connectivity metrics and applies these metrics to evaluate the connectivity of China’s high-speed railway system. Then, through integrating the real-world network topology and travel demand data, we conduct the first data-driven research on comparing the physical connectivity with the logical connectivity of railway systems. The experiments demonstrate that the physical connectivity metrics cannot well represent the connectivity of railway systems, due to the neglect of the heterogeneous distribution and temporal patterns of the passenger flows.
Capillary evaporation in pores

We combine a density functional theory (DFT) treatment of capillary evaporation in a cylindrical pore with the morphometric approach in order to study the formation and breaking of bubbles in a hydrophobically lined part of a cone. The morphometric approach, in which the grand potential of a system is described in four geometrical terms with corresponding thermodynamical coefficients, allows extrapolation or scaling from macroscopic system sizes to nanoscales. Since only a small number of fluid particles are involved in bubble formation, it is a pseudo phase transition, and the system is subjected to fluctuations between states with and without a bubble. Fluctuations are not included in a DFT treatment, which makes it possible to explore both states of the system in great detail, in contrast to computer simulations, in which averages might be obscured by fluctuations.
DMT analysis and optimization for cooperative multiuser OFDMA systems

In this paper, we adopt the DMT framework to study a cooperative downlink OFDMA system with multiple relays. We derive the closed-form expression of the DMT curve for the cooperative OFDMA system employing linear constellation precoding at the base station, and linear detection at the mobile users, and develop the optimal symbol loading, relay selection and subcarrier allocation strategy. Simulation results are presented to verify the theoretical analysis and show that our proposed resource allocation strategy can improve the system performance significantly.
SenCity – Evaluating Users’ Experiences of Intelligent Lighting for Well-Being in Smart Cities

1 This paper presents the evaluation of users’ experiences in three intelligent lighting pilots in Finland. Two of the case studies are related to the use of intelligent lighting in different kinds of traffic areas, having emphasis on aspects of visibility, traffic and movement safety, and sense of security. The last case study presents a more complex view to the experience of intelligent lighting in smart city contexts. The evaluation methods, tailored to each pilot context, include questionnaires, an urban dashboard, in-situ interviews and observations, evaluation probes, and system data analyses. The applicability of the selected and tested methods is discussed reflecting the process and achieved results.
Comparative in vitro release and clinical pharmacokinetics of leuprolide from Luphere 3M Depot, a 3-month release formulation of leuprolide acetate

Abstract A 3-month depot formulation of leuprolide acetate (Luphere 3M Depot) with a mean microsphere diameter of 22.3 μm was prepared aseptically by spray-drying glacial acetic acid solution of the drug and polylactic acid, and lyophilization in a d-mannitol solution. The encapsulation efficiency and loading content of the drug in the Luphere 3M Depot were 94.7% and 9.92% (w/w), respectively. The in vitro release of leuprolide from the depot was substantially delayed and the release profile was similar to that of Lucrin Depot (Abbott Korea, Korea). The safety and pharmacokinetics of leuprolide were investigated over a period of 42 days in 20 prostate cancer patients following a subcutaneous injection of Luphere 3M or Lucrin Depot suspensions (leuprolide acetate dose of 11.25 mg) in a multi-center, randomized, single dose, parallel study. Both formulations were well tolerated by the patients and no serious adverse effects were observed during and after the study. No significant differences were observed in the maximum serum concentration (Cmax) and area under the curve (AUClast) of leuprolide between the two formulations. The results suggest comparable safety and efficacy profiles of Luphere 3M Depot and Lucrin Depot in clinical situations.
Semantics driven adjoints of the message passing interface

Access to correct derivative information is crucial in numerical simulations and optimization. While finite differences easily provide derivative approximations through perturbing a function’s inputs, the adjoint derivative model is the only way of acquiring a function’s gradient both at machine precision and at the same time complexity as the initial function evaluation. However, the adjoint model implies a complete data flow reversal of an executed program. The same implication holds for the Message Passing Interface (MPI) of a parallel implementation. Every communication pattern has to be reversed when the adjoint model is applied. This work establishes a framework for the semantic analysis of MPI communication patterns. It formulates a semantic driven generation of adjoint patterns of the corresponding original patterns. The MPI standard defines the semantics of every MPI communication in English language. A more abstract representation of the MPI semantics is extracted and used in order to apply the logic of Algorithmic Differentiation (AD). Based on these adjoint pattern representations a generic adjoint MPI library is implemented that may be used semi-automatically with any AD tool. Moreover, the runtime expectation of such an implementation on current cluster systems is analyzed. The outcome is tested with two software packages used in numerical science. One is the Portable Extensible Toolkit for Scientific computation (PETSc). It is currently one of the most robust frameworks for parallel linear and nonlinear solvers that exist. The other one is Sisyphe, a sediment transport simulation software used in the context of the fluid solver OpenTELEMAC.
The role of physician recommendation in women's mammography use: is it a 2-stage process?

OBJECTIVE To explore the use of a 2-stage model in explaining the role of physician recommendation in women's use of mammography screening and to provide an integrated framework for understanding the mammography-use process. METHODS Data on 1,301 women aged > or =52 years from the North Carolina Breast Cancer Screening Program (NC-BCSP) questionnaire were combined with information from 91 of their physicians from the North Carolina Medical Board. A 2-stage system of equations using women's characteristics (demographic, health, access), physicians' characteristics (demographic, practice), women's beliefs, and women's report of a physician recommendation was created and statistically tested. The model was estimated using 2-stage logistic and probit estimation. RESULTS The 2-stage approach produced different results compared with the single pooled model. In the second-stage mammography-use model, younger age, family history of breast cancer, and a woman's having ever requested a mammogram retained significance (P < or = 0.05) in addition to the predicted value of physician recommendation obtained from the first stage. Women's characteristics significantly associated with physician recommendation in the first stage included some access, health risk, and demographic variables as well as physician age and race (P < or = 0.05). CONCLUSIONS A 2-stage model for estimating mammography use among women with regular physicians may be more informative than a single model. These results imply that programs designed to increase mammography rates should focus on ensuring appropriate physician recommendations in addition to encouraging women to request screening. Future research should consider using an integrated framework for evaluating utilization of mammography and other preventive services.
Postcollection Rise in Methemoglobin Level in Frozen Blood Specimens

A patient with nonspecific complaints had four previous venous blood samples showing elevated methemoglobin fractions of 15.6–20.1%. Cooximetry on a fresh specimen revealed a methemoglobin fraction of 0.8%, while that reported by the original laboratory on the simultaneously collected specimen was 14.9%. The laboratory assayed the specimen after holding it in frozen storage. Venous blood from a healthy volunteer was assayed by cooximetry after storage under conditions of room temperature (22–24°C), refrigeration (1–4°C), and freezing (−14 to −12°C). Methemoglobin level in frozen-thawed specimens rose over time from 1.8% (0.29 g/dL) at 6 hour to 10.9% (1.71 g/dL) after 6 days. With the exception of a single specimen stored in an EDTA-containing tube at room temperature for 6 days, methemoglobin in nonfrozen specimens never exceeded 0.8% (0.12 g/dL).
Assessing the content and quality of information on the treatment of postmenopausal osteoporosis on the World Wide Web

Objective. To evaluate the content and quality of currently available Internet-based information on the treatment of postmenopausal osteoporosis. Design. A sample was obtained comprising the 75 top sites retrieved with the Google search engine using ‘treatment of postmenopausal osteoporosis’ and then evaluated according to predefined general and specific criteria, content type, language and quality. Using a systematic scoring tool, each site was assessed for factual information provided and site quality. Results. The sites studied were heterogeneous in content and quality. The most frequent type of website corresponded to non-profit organizations (n = 40), followed by commercial sites (n = 19), professional sites (n = 8) and government sites (n = 8). There were no significant differences in the popularity index, medical content score or quality score among the four groups of sites. Twelve websites were papers published in peer-reviewed medical journals. Few sites provided comprehensive medical and complete information on the treatment of postmenopausal osteoporosis oriented towards consumers. The consumer-oriented webpage with the most balanced and complete information was that of the National Osteoporosis Foundation which, at the same time, had the highest popularity index of all the resources studied. Conclusion. The content and quality of websites concerning the treatment of postmenopausal osteoporosis are highly varied and sometimes biased. The most frequent high-quality information corresponds to peer-reviewed medical journals. It is necessary to increase the number of resources, with rigorous language that is understandable for consumers, in relation to the treatment of postmenopausal osteoporosis.
Cell-specific differential expression of Na(+)-channel beta 1-subunit mRNA in the olfactory system during postnatal development and after denervation

Activity-dependent mechanisms have been implicated in olfactory system development but, although such activity requires ion channels, few reports have described their expression in the olfactory system. We investigated the developmental and denervation-induced regulation of the Na(+)-channel beta 1 subunit (Na beta 1) in rat olfactory bulb (OB) and piriform cortex (PC). In situ hybridization shows that Na beta 1 mRNA expression is upregulated developmentally, but with different time courses in mitral, tufted, and pyramidal cells. In mitral cells, label was detected at postnatal day 4 (P4) and gradually increased to P14. Tufted cells were devoid of Na beta 1 mRNA before P14, when most cells expressed adult levels. In pyramidal cells of PC, Na beta 1 expression was not detectable clearly until P14, with maximal expression at P28. To examine the regulation of Na beta 1 mRNA, we surgically deafferented the OB at P30 and compared the effects on Na beta 1 with those for Na(+)-channel alpha-subunit (Na alpha) mRNAs. Within 5 d of surgery, the Na beta 1 and Na alpha II signals within tufted cells disappeared almost completely. Na beta 1 and Na alpha II expression was decreased in mitral cells to low-to-moderate levels. In pyramidal cells, Na beta 1 mRNA expression was decreased moderately without significant changes in Na alpha II mRNA. Deafferentation had no detectable effects on Na alpha I or III mRNAs in either OB or PC. These data indicate that Na beta 1 mRNA is expressed differentially in subpopulations of cells in the olfactory system during development and after deafferentation and suggest that the expression of Na beta 1 is regulated independently of Na alpha mRNAs via cell-specific and pathway-specific mechanisms.
Pragmatic differentiation in early trilingual development*

ABSTRACT This study examines pragmatic differentiation in early trilingual development through a longitudinal analysis of language choice in a developing Tagalog–Spanish–English trilingual child. The child's patterns of language choice with different language users are analyzed at age 1 ; 10 and 2 ; 4 to examine: (1) whether evidence for pragmatic differentiation can be found even before age two and in simultaneous interactions with distinct language users; (2) whether lexical gaps determine the child's choice of one language over another; and (3) whether her patterns of language choice are affected by the interlocutors language use and their responses to mixing. The results indicate that the child was capable of selecting the appropriate language according to the interlocutors' language from the earliest sessions. However, switches to inappropriate languages were common due to vocabulary gaps, the interlocutors' acceptance of mixing and the possibilities determined by the existence of multiple lexical resources and multiple language users.
Global functioning among middle-aged patients with chronic schizophrenia: the role of medication, working memory and verbal comprehension

The chronic phase of schizophrenia is characterized by illness progression and patients encountering difficulties to return to premorbid level of functioning. The objective of this study was to describe the characteristics of a sample of patients with chronic schizophrenia, as well to assess differences between patients under and over 45 years of age. In a clinical sample of 77 chronic schizophrenia patients, we assessed basic symptoms, cognitive performance, social functioning and quality of life. All participants obtained very high scores in residual symptoms, and no differences in sociodemographic or clinical characteristics between the age groups were found. Younger patients had better cognitive performance and older patients obtained better scores for social functioning and quality of life. Number of psychotropic drugs, verbal learning delayed of SCIP, errors in WCST, Similarities and Digit Symbol Coding of WAIS were the most important variables to predict global functioning of patients over 45 years old. Increasing our understanding of differences in characteristics of the chronic phase of the illness and the profile of functioning at different ages, may help us design intervention strategies to improve adaptation in young and middle-aged patients with chronic schizophrenia.
Ultrahigh-energy pulsed emission from Hercules X-1 with anomalous air-shower muon production.

A search for bursts of air-shower events from Hercules X-1 at energies above 50 TeV during the calendar period 2 April 1986 to 5 July 1987 yielded two significant bursts, both occurring on UT 24 July 1986. The events during these bursts were pulsed with a period of 1.235 68 s, significantly different from estimates of the contemporaneous x-ray period. The probability that this represents random statistical fluctuations of the background is estimated to be 2 \ifmmode\times\else\texttimes\fi{} ${10}^{\ensuremath{-}5}$. The muon content of the burst events is anomalous when compared with expectations from $\ensuremath{\gamma}$-ray showers.
Haemodynamic and metabolic effects of timolol (Blocadren) on ischaemic myocardium.

The effects of timolol (2.5 mg i.v.) on coronary haemodynamics and myocardial metabolism were studied in 26 patients with angina pectoris. Cardiac venous flow (CVF) was measured by thermodilution technique. Blood was sampled for metabolic studies. Angina pectoris was induced by atrial pacing and the same heart rate was regained after timolol. Metabolic ischaemia was defined as reduction in myocardial lactate extraction ratio (MLE) by at least 50% and to a ratio below 0.15. The study was completed in 22 patients, 9 of whom fulfilled the metabolic criteria for ischaemia. This subgroup did not differ from the total group in any other respect than in lactate metabolism. Beta-adrenergic blockade reduced myocardial oxygen consumption (MVO2) and CVF significantly at rest, but MVO2, CVF, myocardial glucose uptake and MLE were unchanged during pacing despite a decrease in systolic aortic pressure, ejection time and reduced myocardial free fatty acid uptake. Conclusively, timolol did not reduce MVO2 and metabolic ischaemia during pacing-induced angina.
CSCD: a database for cancer-specific circular RNAs

Abstract Circular RNA (circRNA) is a large group of RNA family extensively existed in cells and tissues. High-throughput sequencing provides a way to view circRNAs across different samples, especially in various diseases. However, there is still no comprehensive database for exploring the cancer-specific circRNAs. We collected 228 total RNA or polyA(-) RNA-seq samples from both cancer and normal cell lines, and identified 272 152 cancer-specific circRNAs. A total of 950 962 circRNAs were identified in normal samples only, and 170 909 circRNAs were identified in both tumor and normal samples, which could be further used as non-tumor background. We constructed a cancer-specific circRNA database (CSCD, http://gb.whu.edu.cn/CSCD). To understand the functional effects of circRNAs, we predicted the microRNA response element sites and RNA binding protein sites for each circRNA. We further predicted potential open reading frames to highlight translatable circRNAs. To understand the association between the linear splicing and the back-splicing, we also predicted the splicing events in linear transcripts of each circRNA. As the first comprehensive cancer-specific circRNA database, we believe CSCD could significantly contribute to the research for the function and regulation of cancer-associated circRNAs.
An Essential Role of the Nuclear Factor of Activated T Cells in the Regulation of the Expression of the Cyclooxygenase-2 Gene in Human T Lymphocytes*

We have previously reported that transcriptional induction of cyclooxygenase-2 (COX-2) isoenzyme occurs early after T cell receptor triggering, suggesting functional implications of cyclooxygenase activity in this process. Here, we identify the cis-acting elements responsible for the transcriptional activation of this gene in human T lymphocytes. COX-2 promoter activity was induced upon T cell activation both in primary resting T lymphocytes and in Jurkat cells. This induction was abrogated by inhibition of calcineurin phosphatase with the immunosuppressive drug cyclosporin A, whereas expression of an active calcineurin catalytic subunit enhanced COX-2 transcriptional activation. Moreover, cotransfection of nuclear factor of activated T cells (NFAT) wild type protein transactivated COX-2 promoter activity. Conversely, dominant negative mutants of NFATc or c-Jun proteins inhibited COX-2 induction. Electrophoretic mobility shift assays and site-directed mutagenesis allowed the identification of two regions of DNA located in the positions −117 and −58 relative to the transcriptional start site that serves as NFAT recognition sequences. These results emphasize the central role that the Ca2+/calcineurin pathway plays in COX-2 transcriptional regulation in T lymphocytes pointing to NFAT/activator protein-1 transcription factors as essential for COX-2 promoter regulation in these cells.
Investigating the biology of alpha herpesviruses with MS‐based proteomics

Viruses are intracellular parasites that can only replicate and spread in cells of susceptible hosts. Alpha herpesviruses (α‐HVs) contain double‐stranded DNA genomes of at least 120 kb, encoding for 70 or more genes. The viral genome is contained in an icosahedral capsid that is surrounded by a proteinaceous tegument layer and a lipid envelope. Infection starts in epithelial cells and spreads to the peripheral nervous system. In the natural host, α‐HVs establish a chronic latent infection that can be reactivated and rarely spread to the CNS. In the nonnatural host, viral infection will in most cases spread to the CNS with often fatal outcome. The host response plays a crucial role in the outcome of viral infection. α‐HVs do not encode all the genes required for viral replication and spread. They need a variety of host gene products including RNA polymerase, ribosomes, dynein, and kinesin. As a result, the infected cell is dramatically different from the uninfected cell revealing a complex and dynamic interplay of viral and host components required to complete the virus life cycle. In this review, we describe the pivotal contribution of MS‐based proteomics studies over the past 15 years to understand the complicated life cycle and pathogenesis of four α‐HV species from the alphaherpesvirinae subfamily: Herpes simplex virus‐1, varicella zoster virus, pseudorabies virus and bovine herpes virus‐1. We describe the viral proteome dynamics during host infection and the host proteomic response to counteract such pathogens.
A Method of Hand Gesture Recognition Based on Multiple Sensors

This paper presents a new method of gesture recognition based on multiple sensors fusion technique. Three kinds of sensors, namely surface Electromyography (sEMG) sensor, 3-axis accelerometer (ACC) and camera, are used together to capture the dynamic hand gesture firstly. Then four types of features are extracted from the three kinds of sensory data to depict the static hand posture and dynamic gesture trajectory characteristics of hand gesture. Finally decision-level multi-classifier fusion method is implemented for hand gesture pattern classification. Experimental results of 4 subjects demonstrate that each kind of sensor data has its advantages and disadvantages in representing hand gestures. And the proposed method could fuse effectively the complementary information from these three types of sensors for dynamic hand gesture recognition.
Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors*

Thyroid hormone receptors (TRs) are critical regulators of growth, differentiation, and homeostasis. TRs function by regulating the expression of thyroid hormone (T3) target genes in both ligand-dependent and -independent pathways. Distinct classes of co-regulatory proteins modulate these two pathways. We show here a novel role of cyclin D1 as a T3-independent co-repressor for TRs. Cyclin D1 interacted with TR in vitro and in cells in a ligand-independent manner. Cyclin D1 acted to repress both the silencing activity of the unliganded TR and the transcriptional activity of the liganded TR. The repression was not due to the inhibition of the binding of TR to the thyroid hormone response element but by serving as a ligand-independent bridging factor to selectively recruit HDAC3 to form ternary complexes. The repression was augmented by increasing expression of HDAC3 but not by HDAC1 and was alleviated by trichostatin A. Thus, cyclin D1 is a novel ligand-independent co-repressor that opens a new paradigm to understand the molecular basis of the silencing action of TR.