Miracle-dz/UniFAR-FTUs huggingface dataset:
A Quantitative Examination of the Relationship between Age, Gender, and Burnout in Public Accounting Professionals in a United States National Firm

Scholars and practitioners agree burnout is a significant problem plaguing the public accounting industry. Burnout is a condition that results from long periods of excessive strain on personal resources, and is often found in public accounting professionals due to the high stress and deadline-driven environment. As the causes for burnout are better understood, the focus has turned to why some individuals are more likely to burnout than others. Identifying who has a tendency to burnout can only help in the quest for solutions. The purpose of this correlational quantitative study was to test the theoretical framework of Maslach and Jackson (1981) by examining the relationship between gender, age, and burnout in a large, national public accounting firm in the United States. Data was collected through anonymous surveys of the client-service professionals of one large, national public accounting firm, and analysis included multiple regression models using age and gender as the independent variables, and the three dimensions of burnout as the dependent variables. Only a weak correlation was identified between age and the dimensions of burnout, while an even weaker correlation resulted between gender and the dimensions of burnout. The results of the study indicated that young, female are more likely to experience the characteristics of burnout, but the regression models were not deemed reliable for use in predicting burnout using age and gender. The data analysis indicated that additional independent variables would be needed to reliably predict the dimensions of burnout within the surveyed population.
Health Communication as Applied Communication Inquiry

The status of individual and collective health and well-being powerfully infl uences the quality of people’s lives. Illness, disease, and infi rmity can cause signifi cant pain, suffering, and expense for those affl icted, as well as for their loved ones (who often provide needed care and support), interfering with people’s work and home life. In response, health-care and health-promotion activities have arisen as important social processes for helping people respond to and prevent illness, enabling them to reduce the problems associated with poor health and to participate as fully as possible in life. Indeed, the modern health-care system—which includes physicians, nurses, other immediate health care providers, public health agencies, health profession educational programs, hospitals, clinics, health maintenance organizations (HMOs), pharmacies, nursing homes, hospices, medical equipment and supply companies, and health insurance companies—is a massive interorganizational infrastructure designed to promote health and well-being (Starr, 1982). Promoting health, however, is a complex process, with the health-care sys-tem often proving diffi cult for people to access and negotiate. Effective communication, consequently, is essential for enabling health-care providers and consumers to access and navigate the system, share relevant information, combat signifi cant health risks, infl u-ence health behaviors, and deliver the best possible health-care. Communication, thus, is important to all aspects of health prevention, maintenance, illness, treatment, and recovery. Applied health communication research is conducted to understand and infl uence the best ways to utilize communication to promote health care and illness treatment. This chapter provides a broad overview
Hey Malware, I Can Find You!

Android smartphones are the most widespread in the world. This is the reason why attackers write code more and more aggressive in order to steal data and other important information stored in the phone. One of the most representative malware that implements the typical trojan behaviour in Android environment is the so-called Fake Installer. In this paper we use formal methods, in particular model checking, in order to identify Fake Installer malware. We specify a set of formulae and then we check these on a designed application model, built in CCS, to recognize whether an application is a malware belonging to Fake Installer family or a legitimate sample. We experiment our methodology on 1125 real world samples obtaining very promising results.
Experimental investigation on PLC signal crossing of power transformers

In this work the use of PLC in MV-LV networks is investigated, by means of experimental tests in the case of a two-ways MV/LV communication between two secondary substations. The two substations are connected by a MV overhead power line. Moreover each substation has a by-pass connection at MV bus-bars and a MV/LV power transformer. A ST7580 transceiver is used to inject the communication signal. The transceiver is embedded in a new interface device developed by the authors. In the paper the communication issues are introduced and some experimental tests are presented and discussed. Such tests have been carried out in the presence of voltage net, i.e. 24 kV, with the aim to verify the possibility of power transformer crossing.
PEDIATRIC AND CONGENITAL HEART DISEASE Original Studies Aortic Valve Morphology Is Associated With Outcomes Following Balloon Valvuloplasty for Congenital Aortic Stenosis

Objectives: Evaluate the incidence of various morphologic types of congenital AS, and the association between valve morphology and long-term outcomes, including repeat BAV, AVR, and death/transplant. Background: Reports on long-term outcomes have low agreement on the influence of morphologic type. Methods: We queried our institutional database and hospital billing records to identify all patients who underwent balloon aortic valvuloplasty (BAV) from 1992 through 2009. We excluded cases where morphology was not clear based on the description in the pre-BAV echocardiogram report and patients who underwent single ventricle palliation. The primary outcome of the study was the occurrence of any of the following events: repeat valvuloplasty, AVR, heart transplant, or death. Results: There were 147 patients in our study cohort. The most common morphology was functionally bicuspid (n 5 92, 63%), followed by functionally unicuspid (n 5 20, 14%), dysplastic (n 5 16, 11%), true bicuspid (n 5 13, 9%), and true unicuspid (n 5 6, 4%). The primary endpoint was less likely to occur in patients with functionally bicuspid valves (P < 0.01) and patients with true bicuspid valves (P 5 0.03), whereas it was more likely to occur in patients with functionally unicuspid valves (P 5 0.02) and patients with true unicuspid valves (P 5 0.05). Multivariate Cox regression analysis demonstrated that valve type other than functionally bicuspid was associated with diminished freedom from repeat intervention, death or transplant (HR 3.3, CI 1.2 – 8.6, P 5 0.02). Conclusions: In our cohort, patients with functionally bicuspid aortic valves, the most common type, had improved outcomes as compared with all other morphologic types. VC 2012 Wiley Periodicals, Inc.
DSSR-enhanced visualization of nucleic acid structures in Jmol

Abstract Sophisticated and interactive visualizations are essential for making sense of the intricate 3D structures of macromolecules. For proteins, secondary structural components are routinely featured in molecular graphics visualizations. However, the field of RNA structural bioinformatics is still lagging behind; for example, current molecular graphics tools lack built-in support even for base pairs, double helices, or hairpin loops. DSSR (Dissecting the Spatial Structure of RNA) is an integrated and automated command-line tool for the analysis and annotation of RNA tertiary structures. It calculates a comprehensive and unique set of features for characterizing RNA, as well as DNA structures. Jmol is a widely used, open-source Java viewer for 3D structures, with a powerful scripting language. JSmol, its reincarnation based on native JavaScript, has a predominant position in the post Java-applet era for web-based visualization of molecular structures. The DSSR-Jmol integration presented here makes salient features of DSSR readily accessible, either via the Java-based Jmol application itself, or its HTML5-based equivalent, JSmol. The DSSR web service accepts 3D coordinate files (in mmCIF or PDB format) initiated from a Jmol or JSmol session and returns DSSR-derived structural features in JSON format. This seamless combination of DSSR and Jmol/JSmol brings the molecular graphics of 3D RNA structures to a similar level as that for proteins, and enables a much deeper analysis of structural characteristics. It fills a gap in RNA structural bioinformatics, and is freely accessible (via the Jmol application or the JSmol-based website http://jmol.x3dna.org).
An Omega Ratio Analysis Of Global Hedge Fund Returns

Hedge funds are notorious for being opaque investment vehicles, operating beyond regulation and out of reach of the average investor. In the past decade, however, they have become increasingly accessible to industry and investors. Hedge fund investment vehicles have become more complex with disparate strategies employed to obtain hedged returns. With this added complexity and impenetrability of managerial tactics, investors need a robust means of distinguishing 'good' funds from 'bad'. The most commonly used ratio to do this is the Sharpe ratio, but hedge funds exhibit non-normal returns because of their use of derivatives, short selling and leverage. The Omega ratio accounts for all moments of the return distribution and in this article, it is used to rank fund returns and compare results obtained with those obtained from the Sharpe ratio over an expansionary period (2001 to 2007) and a period of economic difficulty (2008 to 2013). The Omega ratio is found to provide far superior rankings.
Probing glycine receptor stoichiometry in superficial dorsal horn neurones using the spasmodic mouse

Non‐technical summary Glycine receptors (GlyRs) play an important role in inhibiting neurone activity in the spinal cord. Until recently adult GlyRs were thought to comprise α1 and β subunits. A new form of the receptor containing α3 subunits has been discovered in the superficial dorsal horn (SDH), a region of the spinal cord important for pain. This raises questions about the precise subunit composition of GlyRs and glycinergic synapses in the SDH. We used the spasmodic mouse, where α1 subunit containing GlyRs have altered agonist sensitivity and electrophysiological properties, to ask how α1 and α3 subunits are assembled to form GlyRs on SDH neurones. We found most (∼75%) GlyRs and glycinergic synapses in the SDH contain α1 subunits and few are composed exclusively of α3 subunits. Therefore, future efforts to design pain drugs that target the α3 subunit must consider the potential interaction between α1 and α3 subunits in the GlyR.
Expression of three genes for elongation factor 1 alpha during morphogenesis of Mucor racemosus

Three genes, TEF-1, -2, and -3, encode elongation factor 1 alpha in Mucor racemosus. Neutral and alkaline S1 nuclease analyses revealed that the genetic organization is unique for each of the genes. The number and size of the intervening sequences vary in these closely related genes, which suggests that complex genetic rearrangements gave rise to the elongation factor 1 alpha gene family. Nucleotide sequence data from restriction fragments isolated from the 5' and 3' ends of TEF-2 and -3 confirmed the presence of a second intervening sequence in these genes. These data along with S1 nuclease mapping revealed a region at the 3' end of the three genes which was predicted to be transcribed but untranslated. Unique oligonucleotides containing 19 bases were synthesized to hybridize to this unique trailer region in the elongation factor 1 alpha transcripts. These oligonucleotides were used as probes in standard Northern analysis of RNA purified from M. racemosus cells of several morphological types. It was determined that all three genes were expressed in the cell morphological types studied. However, the accumulated level of transcript derived from each gene varied considerably, with TEF-1 mRNA present in approximately twofold greater quantity than the TEF-3 transcript and up to sixfold greater quantity than TEF-2. The level of TEF-1 and -2 mRNA varied little among the cell morphological types studied, whereas TEF-3 mRNA was present in twofold greater quantity in sporangiospores than in either germlings or yeast cells which had been induced to undergo morphogenesis to hyphae. These data suggest that there is differential expression of the genes encoding elongation factor 1 alpha in M. racemosus. At least one gene, TEF-3, shows a morphology-specific pattern of transcript accumulation.
Expansion of CD133‐Expressing Liver Cancer Stem Cells in Liver‐Specific Phosphatase and Tensin Homolog Deleted on Chromosome 10‐Deleted Mice

PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a lipid phosphatase that regulates mitogenic signaling pathways, and deficiency of PTEN results in cell proliferation, survival, and malignancy. Murine liver‐specific Pten deletion models develop liver malignancy by 12 months of age. Using this model, we describe a population of CD133+ liver cancer stem cells isolated during the chronic injury phase of disease progression and before primary carcinoma formation. We performed immunohistochemistry and flow cytometry isolation using livers from 3‐ and 6‐month‐old PtenloxP/loxP; Alb−Cre+ mice (mutants) and controls. CD133+CD45− nonparenchymal (NP) cells were analyzed for gene expression profile and protein levels. Single CD133+CD45− oval cells were isolated for clonal expansion and tumor analysis. Cultured and freshly isolated liver CD133+CD45− and CD133−CD45− NP cells were injected into immune‐deficient and immune‐competent mice. In mutant mice, the NP fraction increased in CD133+CD45− cells in 3‐ and 6‐month‐old Pten‐deleted animals compared with controls. Clone lines expanded from single CD133+CD45− cells demonstrated consistent liver progenitor cell phenotype, with bilineage gene expression of hepatocyte and cholangiocyte markers. CD133+ cells from expanded clone lines formed robust tumors in immune‐deficient and immune‐competent mice. Furthermore, freshly isolated CD133+CD45− NP liver cells from 6‐month‐old mutants formed tumors in vivo, and CD133−CD45− NP cells did not. Consistent with a cancer stem cell phenotype, CD133+ cells demonstrate resistance to chemotherapy agents compared with CD133− cells. CD133+CD45− nonparenchymal cells from chronic injury PtenloxP/loxP; Alb−Cre+ mice represent a bipotent liver progenitor cell population with cancer stem cell phenotype. STEM CELLS 2009;27:290–299
Recurrent epithelial ovarian cancer: pharmacotherapy and novel therapeutics

Epithelial ovarian cancer will strike between 1 – 2% of women in developed countries and, unfortunately, it largely remains a lethal disease due to late-stage at diagnosis and the eventual development of chemotherapy resistance. Ovarian cancer is initially treated with surgical resection and chemotherapy (primarily platinum/taxane combinations) and remission can be attained for the majority of patients. Despite this, most women will recur and require multiple further therapies. The purpose of this paper is to review the existing treatment options, including surgery, traditional chemotherapy as well as upcoming novel and targeted therapies that may one day improve outcomes in this disease.
Structure-Function Analysis of SUV39H1 Reveals a Dominant Role in Heterochromatin Organization, Chromosome Segregation, and Mitotic Progression

ABSTRACT SUV39H1, a human homologue of theDrosophila position effect variegation modifierSu(var)3-9 and of theSchizosaccharomyces pombe silencing factorclr4, encodes a novel heterochromatic protein that transiently accumulates at centromeric positions during mitosis. Using a detailed structure-function analysis of SUV39H1 mutant proteins in transfected cells, we now show that deregulated SUV39H1 interferes at multiple levels with mammalian higher-order chromatin organization. First, forced expression of full-length SUV39H1 (412 amino acids) redistributes endogenous M31 (HP1β) and induces abundant associations with inter- and metaphase chromatin. These properties depend on the C-terminal SET domain, although the major portion of the SUV39H1 protein (amino acids 89 to 412) does not display affinity for nuclear chromatin. By contrast, the M31 interaction surface, which was mapped to the first 44 N-terminal amino acids, together with the immediately adjacent chromo domain, directs specific accumulation at heterochromatin. Second, cells overexpressing full-length SUV39H1 display severe defects in mitotic progression and chromosome segregation. Surprisingly, whereas localization of centromere proteins is unaltered, the focal, G2-specific distribution of phosphorylated histone H3 at serine 10 (phosH3) is dispersed in these cells. This phosH3 shift is not observed with C-terminally truncated mutant SUV39H1 proteins or with deregulated M31. Together, our data reveal a dominant role(s) for the SET domain of SUV39H1 in the distribution of prominent heterochromatic proteins and suggest a possible link between a chromosomal SU(VAR) protein and histone H3.
Negotiating the Gender Wage Gap

There is some evidence that gender differences exist in the propensity to negotiate and outcomes from negotiation. We examine the propensity to negotiate over pay with the employer, the wage outcomes resulting from negotiation, and the impact on the gender wage gap. We find evidence that females are less likely to have the opportunity to negotiate over pay. However, conditional on the opportunity to negotiate, they are no less likely to actually negotiate. The analysis does not provide strong evidence that women fare worse than men if negotiation occurs.
Commande optimale basée sur le modèle d'un bâtiment pour le chauffage intermittent

Des economies d'energie substantielles sont envisageables sur le chauffage des bâtiments a occupation intermittente. Nous proposons ici une regulation basee sur les techniques de la Commande Optimale pour la minimisation de l'energie. Une strategie unique est developpee pour les periodes d'occupation et d'inoccupation. Un parametrage variable du critere de performance permet de ponderer le rapport confort/consommation.
Assessment of anticoagulation using activated clotting times in patients receiving intravenous enoxaparin during percutaneous coronary intervention

Enoxaparin is being used more frequently in patients undergoing percutaneous coronary intervention (PCI). In this study, we determined the effect of intravenous enoxaparin on activated clotting time (ACT) measurements in the setting of PCI. In 67 consecutive patients, either 1 mg/kg intravenous enoxaparin alone was given for anticoagulation or 0.75 mg/kg given in patients receiving eptifibatide. ACT was measured before and 5 min following enoxaparin administration. After 1 mg/kg enoxaparin (n = 22), mean ACT increased from 122 ± 22 to 199 ± 20 sec. After 0.75 mg/kg enoxaparin and eptifibatide (n = 45), mean ACT increased from 125 ± 22 to 194 ± 24 sec. The mean increase in ACT was 77 ± 26 sec in the 1 mg/kg group and 69 ± 23 sec in the 0.75 mg/kg group (both P values < 0.0001). Moreover, in a subgroup of 26 patients, there was an excellent correlation (r = 0.86) between ACTs and the ENOX test, a new point‐of‐care test for assessing enoxaparin anticoagulation. None of the patients had transient abrupt closure, thrombus formation, major bleeding, or required urgent revascularization. Intravenous enoxaparin at clinically relevant doses with and without eptifibatide increases ACT levels at 5 min in patients undergoing PCI. These data suggest the ACT may be useful in the assessment of anticoagulation by enoxaparin. Catheter Cardiovasc Interv 2004;61:52–55. © 2004 Wiley‐Liss, Inc.
Improving detector performance by learning from compressed samples

Increasing data volumes coupled with bandwidth limitations in on-board data transmission paths make data compression of automotive video signals indispensable. Since traditional image compression algorithms are solely tuned for optimal human perception, this work studies their effect on a nighttime automotive pedestrian detection system. Evaluating raw-data trained detectors on compressed video streams reveals detection rate declines for strong compression factors. On the other hand, when using image compression as training data preprocessing tool an increase in detection performance can be achieved.
[Validity of self-reported body mass index in the National Health Survey].

OBJECTIVE To assess the validity of self-reported body mass index in the National Health Survey. METHODS 120 participants were selected and questioned about their weight and height with exactly the same questions that the National Health Survey uses. Afterwards, and once informed consent was obtained, participants were weighed and measured, and this data was used as the gold standard. RESULTS On average, participants underestimated their weight by 1.39 kg, overestimated their height by 0.55 cm and underestimated their body mass index by 0.71 kg/m2. The sensitivity of self-reported self reported body mass index (BMI) to detect overweight was 77%, the specificity was 97%, the positive predictive value was 0.95 and the negative predictive value was 0.86. The Kappa index was 0.76 and the quadratically weighted Kappa index was 0.85. The correlation coefficient between self-reported and measured BMI was 0.96 and the intra-class correlation coefficient was 0.97. CONCLUSIONS Self-reported data is an efficient way of obtaining information about BMI, although with limitations, because self-reported data tends to underestimate weight and overestimate height, thus underestimating BMI and the proportion of participants with elevated BMI.