Miracle-dz/UniFAR-FTUs huggingface dataset:
Presence of metabolic syndrome in football linemen.

CONTEXT Metabolic syndrome is a clustering of symptoms associated with abdominal obesity that demonstrates a high risk for cardiovascular disease and type II diabetes mellitus. OBJECTIVE To evaluate football linemen in National Collegiate Athletic Association Divisions I, II, and III schools for the presence of metabolic syndrome according to the American Heart Association/National Heart, Lung, and Blood Institute criteria as well as to document other related biomarkers. DESIGN Cross-sectional descriptive study. SETTING Three university locations on the first full day of football camp in early morning. PATIENTS OR OTHER PARTICIPANTS Of 76 football linemen, 70 were able to provide blood samples. MAIN OUTCOME MEASURE(S) Height, mass, blood pressure, upper-body skinfolds, and waist circumference were measured at various stations. Two small venous samples of blood were collected and analyzed in a hospital laboratory for fasting insulin, glucose, high-density lipoprotein, total cholesterol, triglycerides, C-reactive protein, and glycosylated hemoglobin. The last station was a verbal family history for cardiovascular disease and diabetes; also, athletes filled out a nutrition attitudes questionnaire. RESULTS Of the 70 athletes, 34 were identified as having metabolic syndrome according to measures of blood pressure, waist circumference, fasting glucose, high-density lipoprotein, and triglycerides. The mean total cholesterol-to-high-density lipoprotein cholesterol ratio for the group was 4.95, with 32 participants displaying values higher than 5.0. Twelve volunteers had total cholesterol levels greater than 200 mmol/L, 15 had high levels of C-reactive protein, and 9 had slightly elevated levels of glycosylated hemoglobin. CONCLUSIONS Although athletes might be assumed to be protected from risks of cardiovascular disease, we found a high incidence of metabolic syndrome and other associated adverse biomarkers for heart disease in collegiate football linemen. Early screening, awareness, and intervention may have favorable effects on the overall health outcomes of football linemen.
Na+/K+/Cl− cotransporter activates MAP‐kinase cascade downstream to protein kinase C, and upstream to MEK

In this study, we demonstrated that the specific inhibitors of the Na+/K+/Cl− cotransporter (NKCC1), bumetanide and furosemide, inhibited extracellular regulated kinase (ERK) phosphorylation in Balb/c 3T3 fibroblasts, stimulated with a variety of mitogens. In addition to fibroblast growth factor (FGF) shown before, the various mitogens tested in the present study (endothelial growth factor (EGF), platelet‐derived growth factor (PDGF), insulin, thrombin, and the phorbol ester, 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA)). Enter, the Ras/Raf/MEK/ERK cascade via different growth factors receptors and through one of the two main routes. The results of the present study provide evidence that have led us to conclude that the target protein which is controlled by the Na+/K+/Cl− cotransporter, is downstream of tyrosine kinase receptors, as well as of the G‐protein‐coupled receptor (GPCR). Several additional lines of evidence supported the above conclusion: (i) furosemide inhibits phosphorylation of MAPK kinase (MEK) induced by receptor tyrosine kinase (RTK) ligands, such as PDGF, FGF, and EGF. (ii) Furosemide also inhibited ERK phosphorylation, induced by thrombin, a GPCR. (iii) Furosemide inhibited MEK and ERK phosphorylation even when ERK phosphorylation was induced by direct activation of protein kinase C (PKC) by TPA, which bypasses early steps of the mitogenic cascade. In addition, we found that furosemide did not affect PKC phosphorylation induced directly by TPA. Taken together, the results of the present study indicate that the signal transduction protein, controlled by the Na+/K+/Cl− cotransporter, must be downstream of the PKC, and at/or upstream to MEK in the Ras/Raf/MEK/ERK cascade. © 2005 Wiley‐Liss, Inc.
Evaluation of a particle swarm optimization controller for dc-dc boost converters

Particle swarm optimization has been used as a tuning algorithm for dc-dc converter controllers. In this work it is proposed a novel approach where the PSO is used as the controller itself for a dc-dc boost converter. The PSO controller uses a population of particles to achieve the necessary compensation to stabilize the output at reference voltage. The algorithm uses the gain formula to reposition the particles near the required position, to stabilize the output at reference voltage, according to the disturbances in the converter. Simulations have been carried on in order to observe the controller's response to changes in reference voltage and in load variance.
Assessment of ECG frequency and morphology parameters for automatic classification of life-threatening cardiac arrhythmias

The reliable recognition and adequate electrical shock therapy of life-threatening cardiac states depend on the electrocardiogram (ECG) descriptors which are used by the defibrillator-embedded automatic arrhythmia analysis algorithms. We propose a method for real-time ECG processing and parameter set extraction using band-pass digital filtration and ECG peak detection. Twelve parameters were derived: (i) seven parameters from the band-pass filter output—six threshold parameters and one peak counter; (ii) five parameters from the ECG peak detection branch, which assess the heart rate, the periodicity and the amplitude/slope symmetry of the ECG peaks. The statistical assessment for more than 36 h of cardiac arrhythmia episodes collected from the public AHA and MIT databases showed that some of the parameters achieved high specificity and sensitivity, but there was no parameter providing 100% separation between non-shockable and shockable rhythms. In order to estimate the influence of the wide variety of cardiac arrhythmias and the different artifacts in real recording conditions, we performed a more detailed study for eight non-shockable and four shockable rhythm categories. The combination of the six top-ranked parameters provided specificity: (i) more than 99% for rhythms with narrow supraventricular complexes, premature ventricular contractions, paced beats and bradycardias; (ii) almost 95% for supraventricular tachycardias; (iii) 91.5% for bundle branch blocks; (iv) 92.2% for slow ventricular tachycardias. The attained sensitivity was above 98% for coarse and fine ventricular fibrillations and 94% for the rapid ventricular tachycardias. The accuracy for the noise contaminated non-shockable and shockable signals exceeded 93%. The proposed parameter set guarantees an accuracy that meets the AHA performance goal for each rhythm category and could be a reliable facility for AED shock-advisory algorithms.
Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner ear

Connexin 26 (Cx26) and connexin 30 (Cx30) are encoded by two genes (GJB2 and GJB6, respectively) that are found within 50 kb in the same complex deafness locus, DFNB1. Immunocytochemistry and quantitative PCR analysis of Cx30 KO mouse cultures revealed that Cx26 is downregulated at the protein level and at the mRNA level in nonsensory cells located between outer hair cells and the stria vascularis. To explore connexin coregulation, we manipulated gene expression using the bovine adeno-associated virus. Overexpression of Cx30 in the Cx30 KO mouse by transduction with bovine adeno-associated virus restored Cx26 expression, permitted the formation of functional gap junction channels, and rescued propagating Ca2+ signals. Ablation of Cx26 by transduction of Cx26loxP/loxP cultures with a Cre recombinase vector caused concurrent downregulation of Cx30 and impaired intercellular communication. The coordinated regulation of Cx26 and Cx30 expression appears to occur as a result of signaling through PLC and the NF-κB pathway, because activation of IP3-mediated Ca2+ responses by stimulation of P2Y receptors for 20 min with 20 nM ATP increased the levels of Cx26 transcripts in Cx30 KO cultures. This effect was inhibited by expressing a stable form of the IκB repressor protein that prevents activation/translocation of NF-κB. Thus, our data reveal a Ca2+-dependent control in the expression of inner ear connexins implicated in hereditary deafness as well as insight into the hitherto unexplained observation that some deafness-associated DFNB1 alleles are characterized by hereditable reduction of both GJB2 and GJB6 expression.
Association of ADAMTS4 and ADAMTS9 levels with cardiovascular risk in patients with primary hyperparathyroidism

ABSTRACT Purpose: Primary hyperparathyroidism (PHPT) has been associated with increased incidence of morbidity and mortality of the cardiovascular system. The pathogenetic mechanisms underlying this association are still not completely clear. A disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) play a critical role in atherosclerosis. This study aimed to investigate the levels of ADAMTS4 and ADAMTS9 and relationship between these proteoglycanases and cardiometabolic abnormalities in PHPT. Materials and Methods: A case-control study was performed in a training and research hospital. Fifty-six patients with PHPT and 61 healthy volunteers were recruited. The Framingham score was used to calculate cardiovascular risk (CVR). Serum ADAMTS levels were determined by a human enzyme-linked immunoassay in all subjects. Results: The ADAMTS9 concentration was significantly higher in patients with PHPT than in the control group (p < 0.05); however, there were no significant differences in ADAMTS4 levels between the groups (p > 0.05). In ROC curve analysis, PHPT can be predicted by the use of ADAMTS9 at a cut-off value of 30.7 pg/mL (69% sensitivity, 65% specificity). CVR score was significantly increased in the PHPT than controls (p < 0.05). ADAMTS4 and ADAMTS9 levels had positive correlations with CVR score (r = 0.322, p = 0.017; r = 0.275, p = 0.044 respectively). Conclusions: Based on the results of the present study, cardiovascular risk is increased in PHPT and associated with ADAMTS4 and ADAMTS9. Further efforts are needed to establish the function of ADAMTS proteases in both PHPT and atherosclerosis.
Trends in timing of initiation of chronic dialysis in the United States.

BACKGROUND During the past decade, a trend has been observed in the United States toward initiation of chronic dialysis at higher levels of estimated glomerular filtration rate. This likely reflects secular trends in the composition of the dialysis population and a tendency toward initiation of dialysis earlier in the course of kidney disease. METHODS The goal of this study was to generate model-based estimates of the magnitude of changes in the timing of dialysis initiation between 1997 and 2007. We used information from a national registry for end-stage renal disease on estimated glomerular filtration rate at initiation among patients who received their first chronic dialysis treatment in 1997 or 2007. We used information regarding predialysis estimated glomerular filtration rate slope from an integrated health care system. RESULTS After accounting for changes in the characteristics of new US dialysis patients from 1997 to 2007, we estimate that chronic dialysis was initiated a mean of 147 days earlier (95% confidence interval, 134-160) in the later compared with the earlier year. Differences in timing were consistent across a range of patient subgroups but were most pronounced for those aged 75 years or older; the mean difference in timing in that subgroup was 233 days (95% confidence interval, 206-267). CONCLUSIONS Chronic dialysis appears to have been initiated substantially earlier in the course of kidney disease in 2007 compared with 1997. In the absence of strong evidence to suggest that earlier initiation of chronic dialysis is beneficial, these findings call for careful evaluation of contemporary dialysis initiation practices in the United States.
Whole-exome sequencing confirmation of a novel heterozygous mutation in RUNX1 in a pregnant woman with platelet disorder

Abstract We describe a successful pregnancy and delivery in a patient with platelet disorder. Prophylactic platelet transfusions ensured that there were no bleeding complications during and after cesarean section. Following delivery, we performed whole exome sequencing, using next generation sequencing, to analyze the DNA samples of the patient and her family, and to identify the disease-causing mutation or variant. To identify de-novo mutations systematically, we also analyzed DNA isolated from the parents of the patient and the neonate. We successfully identified a causative novel mutation c.419 G > A (p.S140N) in RUNX1 in the patient and the neonate. Mutations of RUNX1 have been reported to be associated with familial platelet disorder and with a predisposition for myelodysplasia and/or acute myeloid leukemia. The patient and the neonate require careful long-term hematological follow-up. Identification of mutations by a through whole-exome analysis using next-generation sequencing may be useful in the determination of a long-term follow-up schedule for the patient.
Inpatient versus Outpatient Management of TIA or Minor Stroke: Clinical Outcome.

BACKGROUND The management of patients with acute transient ischemic attack (TIA) or minor stroke is highly variable. Whether hospitalization of such patients significantly improves short-term clinical outcome is unknown. We assessed the short-term clinical outcome associated with inpatient versus outpatient management of patients with TIA or minor stroke. METHODS We evaluated a consecutive series of patients with acute TIA or minor ischemic stroke (NIH Stroke Scale score ≤ 3) presenting to a single emergency department (ED). We randomized patients to either hospital-based or outpatient-based management. All patients underwent interview and examination 7-10 days following the index event. RESULTS This study included 100 patients, 41 with TIA and 59 with minor stroke. Nineteen (46%) of the TIA patients and 29 (49%) of the minor stroke patients randomized to hospital management, and the remaining 22 TIA patients and 30 minor stroke patients randomized to outpatient-based management. In the patients with a minor stroke, neurologic worsening occurred in 6 out of 29 (21%) in the inpatient arm compared with 3 out of 30 (10%) in the outpatient arm (p = 0.3). In none of these cases was acute interventional therapy or need for urgent admission considered medically appropriate. In the patients with a TIA, recurrence of a TIA occurred in 2 out of 19 (11%) in the inpatient arm compared with 2 out of 22 (9%) in the outpatient arm (p = 1). None of the patients with a TIA randomized to the inpatient arm experienced a stroke compared with 1 out of 22 in the outpatient arm (p = 1). There were no deaths in either group. CONCLUSION Routine hospitalization of all patients with TIA or minor ischemic stroke may not positively affect short-term clinical outcome.
Foreign direct investment and air pollution in Asian countries: does institutional quality matter?

ABSTRACT This paper empirically studies how foreign direct investment (FDI) affects air pollution, and how this effect depends on institutional quality. By using a panel data for 19 developing Asian countries over the period of 2002–2015, we find that FDI inflows initially increase air pollution in Asia, and the institutional quality improvement helps reduce this effect until the institutional quality achieves a threshold, then beyond this threshold, FDI reduces air pollution. The findings indicate that the pollution haven hypothesis and the pollution halo hypothesis are not contradictory when the institutional quality is taken into consideration.
Sub-band pre-channel compensation-at RS for MC-CDMA downlink relay system

In this paper, we consider a relay system for a downlink communication of multi carrier code division multiple access (MC-CDMA) to improve the performance of cell-edge. However since different signals from the base station and the relay station affect different frequency-selective fading channels, the use of frequency-domain equalization at a receiver cannot restore the orthogonality of these signals. Therefore, bit error rate (BER) performance severely degrades due to large multiaccess interference (MAI). We have proposed a channel compensation method at the relay station for MC-CDMA to improve the performance of the downlink relay system. In this method, the channel response from the relay station to the terminal is compensated to be the same channel response from the base station to the terminal at the receiver terminal. Therefore, MAI can be reduced and BER performance is improved. However, the compensation causes the problem of reducing the effect of frequency domain diversity gain by using relay station. Therefore, in this paper, we also propose a sub-band pre-channel compensation at the relay station for MC-CDMA downlink relay system to obtain the diversity gain.
Summing nondetects: Incorporating low‐level contaminants in risk assessment

Low‐level contaminants often are present below the detection or reporting limits of a laboratory, resulting in values reported as a nondetect or less‐than. How can these values be summed along with detected concentrations to obtain a total, particularly when weighting factors such as toxic equivalence factors (TEFs) are used? The most common method employed by environmental scientists for summing nondetects along with detected values is to substitute one‐half the detection limit for each nondetect. This substitution allows the least precise measurements, data with high detection limits, to have a strong influence on the resulting total amount. Substitution methods have repeatedly been shown to provide substandard results in studies over the last 2 decades. Here an alternative, the Kaplan–Meier (KM) method used throughout the fields of medical and industrial statistics, is used to obtain the total. KM estimates are far less affected by the least precise data than are estimates computed using substitution. No assumptions about the distribution of data (whether they follow a normal or other distribution) need be made. Direct application of KM to computation of toxicity equivalence concentrations (TECs) is shown. Integr Environ Assess Manag 2010;6:361–366. © 2009 SETAC
The Political Boundaries of Ethnic Divisions

We use a policy experiment in Indonesia to show how local political boundaries affect ethnic tension. Redrawing district borders along group lines reduces conflict. However, the gains in stability are undone or even reversed when new boundaries increase ethnic polarization. Greater polarization leads to more violence around majoritarian elections but has little effect around lower-stakes, proportional representation elections. These results point to distinct incentives for violence in winner-take-all settings with contestable public resources. Overall, our findings illustrate the promise and pitfalls of redrawing borders in diverse countries where it is infeasible for each group to have its own administrative unit. (JEL D72, D74, J15, O15, O17, O18)
Cognitive‐behavioral therapy for depression in Parkinson's disease: A pilot study

The present study was conducted to examine the feasibility and effect of an individual cognitive‐behavioral treatment (CBT) for depression that was modified to meet the unique needs of the PD patient and incorporated a separate social support intervention for caregivers. Fifteen PD patients with Major Depressive Disorder participated in the study with a caregiver. Patients received 10–14 sessions of modified individual CBT. Caregivers attended 3–4 psychoeducational sessions, occurring separately from the patients treatment sessions, which focused on strategies for offering appropriate support, and ways to respond to the patients' negative thoughts in a targeted manner. Patients experienced a significant reduction in depressive symptoms and negative cognitions, and an increased perception of social support over the course of treatment. Gains were maintained at 1‐month follow‐up. In conclusion, individual CBT, when modified appropriately, may be a feasible and effective option for PD depression. Larger, randomized controlled trials are needed to further evaluate the efficacy of this intervention and to identify specific mechanisms of change. © 2007 Movement Disorder Society
Asset Pricing with Random Volatility

This paper proposes to model asset price dynamics with a mixture of diffusion processes where the instantaneous volatility of the underlying diffusion process contains a random vector. The marginal probability distributions of the proposed process can match exactly the risk-neutral distributions implied by both spot vanilla options and forward start options. We can also derive the explicit pricing formula for derivatives that have a closed-form solution under Generalized Geometric Brownian Motion.
Solving optimal power flow problems subject to distributed generator failures via particle swarm intelligence

Distributed generation (DG) of power has played an ever-increasing role in a smart power system, often termed as a smart grid. Their use can, however, cause more risk to the entire system since their power outputs are often affected by uncontrollable environments, e.g., weather. Power flow problems as a nonlinear optimization one become much more challenging when one or more distributed generators fail to achieve their desired performance levels. This work formulates a particle swarm optimization method to solve them by considering controllable and uncontrollable distributed generators in a smart grid. Such a method is often sensitive to the initialization conditions and weighting factors. This work presents several typical different initialization strategies and decides the most suitable weighting factors. They are comprehensively investigated via an IEEE 14-bus system subject to the failure of uncontrollable distributed generators.
Evaluating a Deterministic Shift-Reduce Neural Parser for Constituent Parsing

Greedy transition-based parsers are appealing for their very fast speed, with reasonably high accuracies. In this paper, we build a fast shift-reduce neural constituent parser by using a neural network to make local decisions. One challenge to the parsing speed is the large hidden and output layer sizes caused by the number of constituent labels and branching options. We speed up the parser by using a hierarchical output layer, inspired by the hierarchical log-bilinear neural language model. In standard WSJ experiments, the neural parser achieves an almost 2.4 time speed up (320 sen/sec) compared to a non-hierarchical baseline without significant accuracy loss (89.06 vs 89.13 F-score).