Miracle-dz/UniFAR-FTUs huggingface dataset:
Utilization and Cost of Mental Health, Substance Abuse, and Medical Services among At-Risk Drinkers

The objective of this research was to examine whether users of mental health or substance abuse (MH/SA) services incurred greater costs for non-MH/SA services than nonusers of MH/SA services. Two years of health care utilization data were collected on 443 at-risk drinkers from six southern U.S. states. We then examined predictors of using MH/SA services and costs associated with non-MH/SA services. The results showed that use of MH/SA services was associated with female gender, military service, health insurance, and not being employed full-time. Unadjusted analyses indicated that non-MH/SA service costs were significantly higher among MH/SA service users than nonusers. However, this association did not endure in multivariable models. In fact, emergency department costs were significantly lower among MH/SA users. It is commonly assumed that users of MH/SA services are also heavy users of other medical services. Through multivariable models, this study found that overall costs of non-MH/SA services were similar between users and nonusers of MH/SA services.
Classification methods to detect sleep apnea in adults based on respiratory and oximetry signals: a systematic review

Objective: Sleep apnea (SA), a common sleep disorder, can significantly decrease the quality of life, and is closely associated with major health risks such as cardiovascular disease, sudden death, depression, and hypertension. The normal diagnostic process of SA using polysomnography is costly and time consuming. In addition, the accuracy of different classification methods to detect SA varies with the use of different physiological signals. If an effective, reliable, and accurate classification method is developed, then the diagnosis of SA and its associated treatment will be time-efficient and economical. This study aims to systematically review the literature and present an overview of classification methods to detect SA using respiratory and oximetry signals and address the automated detection approach. Approach: Sixty-two included studies revealed the application of single and multiple signals (respiratory and oximetry) for the diagnosis of SA. Main results: Both airflow and oxygen saturation signals alone were effective in detecting SA in the case of binary decision-making, whereas multiple signals were good for multi-class detection. In addition, some machine learning methods were superior to the other classification methods for SA detection using respiratory and oximetry signals. Significance: To deal with the respiratory and oximetry signals, a good choice of classification method as well as the consideration of associated factors would result in high accuracy in the detection of SA. An accurate classification method should provide a high detection rate with an automated (independent of human action) analysis of respiratory and oximetry signals. Future high-quality automated studies using large samples of data from multiple patient groups or record batches are recommended.
Graphene Oxide–Silver Nanocomposite Enhances Cytotoxic and Apoptotic Potential of Salinomycin in Human Ovarian Cancer Stem Cells (OvCSCs): A Novel Approach for Cancer Therapy

The use of graphene to target and eliminate cancer stem cells (CSCs) is an alternative approach to conventional chemotherapy. We show the biomolecule-mediated synthesis of reduced graphene oxide–silver nanoparticle nanocomposites (rGO–Ag) using R-phycoerythrin (RPE); the resulting RPE–rGO–Ag was evaluated in human ovarian cancer cells and ovarian cancer stem cells (OvCSCs). The synthesized RPE–rGO–Ag nanocomposite (referred to as rGO–Ag) was characterized using various analytical techniques. rGO–Ag showed significant toxicity towards both ovarian cancer cells and OvCSCs. After 3 weeks of incubating OvCSCs with rGO–Ag, the number of A2780 and ALDH+CD133+ colonies was significantly reduced. rGO–Ag was toxic to OvCSCs and reduced cell viability by mediating the generation of reactive oxygen species, leakage of lactate dehydrogenase, reduced mitochondrial membrane potential, and enhanced expression of apoptotic genes, leading to mitochondrial dysfunction and possibly triggering apoptosis. rGO–Ag showed significant cytotoxic potential towards highly tumorigenic ALDH+CD133+ cells. The combination of rGO–Ag and salinomycin induced 5-fold higher levels of apoptosis than each treatment alone. A combination of rGO–Ag and salinomycin at very low concentrations may be suitable for selectively killing OvCSCs and sensitizing tumor cells. rGO–Ag may be a novel nano-therapeutic molecule for specific targeting of highly tumorigenic ALDH+CD133+ cells and eliminating CSCs. This study highlights the potential for targeted therapy of tumor-initiating cells.
The Effects of Continuous Positive Airway Pressure on Premature Ventricular Contractions and Ventricular Wall Stress in Patients with Heart Failure and Sleep Apnea

Background We aimed to investigate the effects of continuous positive airway pressure (CPAP) treatment on electrocardiography (ECG), premature ventricular contraction load on 24-hour Holter recordings, and implantable cardioverter defibrillator (ICD) shocks in patients with obstructive sleep apnea syndrome (OSAS) and heart failure. Methods Patients with heart failure and ICD and patients with newly diagnosed OSAS were divided into two groups according to CPAP treatment. To compare the impact of CPAP on ECG parameters, both baseline and 6-month ECG, 24-hour Holter ECG, ambulatory blood pressure monitoring, echocardiography, polysomnography, and laboratory parameters were collected. Results CPAP treatment significantly reduced the frequency of premature ventricular contractions, T-peak to T-end, corrected QT, corrected QT dispersion, and T-peak to T-end/corrected QT ratio in the study group (p < 0.001 for all). Although the baseline NT-pro-BNP levels were similar between study and control groups, after six months, the NT-pro-BNP levels of the study group were significantly lower than that of the control group (39.18 ± 7.57 versus 46.11 ± 7.65; p < 0.001). Conclusions CPAP treatment in patients with heart failure and ICD and in patients with newly diagnosed OSAS may have beneficial effects on premature ventricular contractions and electrocardiographic arrhythmia indices and NT-pro-BNP levels. However, these results are needed to be clarified with further studies.
Revertant mosaicism repairs skin lesions in a patient with keratitis-ichthyosis-deafness syndrome by second-site mutations in connexin 26

Abstract Revertant mosaicism (RM) is a naturally occurring phenomenon where the pathogenic effect of a germline mutation is corrected by a second somatic event. Development of healthy-looking skin due to RM has been observed in patients with various inherited skin disorders, but not in connexin-related disease. We aimed to clarify the underlying molecular mechanisms of suspected RM in the skin of a patient with keratitis-ichthyosis-deafness (KID) syndrome. The patient was diagnosed with KID syndrome due to characteristic skin lesions, hearing deficiency and keratitis. Investigation of GJB2 encoding connexin (Cx) 26 revealed heterozygosity for the recurrent de novo germline mutation, c.148G > A, p.Asp50Asn. At age 20, the patient developed spots of healthy-looking skin that grew in size and number within widespread erythrokeratodermic lesions. Ultra-deep sequencing of two healthy-looking skin biopsies identified five somatic nonsynonymous mutations, independently present in cis with the p.Asp50Asn mutation. Functional studies of Cx26 in HeLa cells revealed co-expression of Cx26-Asp50Asn and wild-type Cx26 in gap junction channel plaques. However, Cx26-Asp50Asn with the second-site mutations identified in the patient displayed no formation of gap junction channel plaques. We argue that the second-site mutations independently inhibit Cx26-Asp50Asn expression in gap junction channels, reverting the dominant negative effect of the p.Asp50Asn mutation. To our knowledge, this is the first time RM has been reported to result in the development of healthy-looking skin in a patient with KID syndrome.
Patients’ and physicians’ preferences for type 2 diabetes mellitus treatments in Spain and Portugal: a discrete choice experiment

Objective To assess Spanish and Portuguese patients’ and physicians’ preferences regarding type 2 diabetes mellitus (T2DM) treatments and the monthly willingness to pay (WTP) to gain benefits or avoid side effects. Methods An observational, multicenter, exploratory study focused on routine clinical practice in Spain and Portugal. Physicians were recruited from multiple hospitals and outpatient clinics, while patients were recruited from eleven centers operating in the public health care system in different autonomous communities in Spain and Portugal. Preferences were measured via a discrete choice experiment by rating multiple T2DM medication attributes. Data were analyzed using the conditional logit model. Results Three-hundred and thirty (n=330) patients (49.7% female; mean age 62.4 [SD: 10.3] years, mean T2DM duration 13.9 [8.2] years, mean body mass index 32.5 [6.8] kg/m2, 41.8% received oral + injected medication, 40.3% received oral, and 17.6% injected treatments) and 221 physicians from Spain and Portugal (62% female; mean age 41.9 [SD: 10.5] years, 33.5% endocrinologists, 66.5% primary-care doctors) participated. Patients valued avoiding a gain in bodyweight of 3 kg/6 months (WTP: €68.14 [95% confidence interval: 54.55–85.08]) the most, followed by avoiding one hypoglycemic event/month (WTP: €54.80 [23.29–82.26]). Physicians valued avoiding one hypoglycemia/week (WTP: €287.18 [95% confidence interval: 160.31–1,387.21]) the most, followed by avoiding a 3 kg/6 months gain in bodyweight and decreasing cardiovascular risk (WTP: €166.87 [88.63–843.09] and €154.30 [98.13–434.19], respectively). Physicians and patients were willing to pay €125.92 (73.30–622.75) and €24.28 (18.41–30.31), respectively, to avoid a 1% increase in glycated hemoglobin, and €143.30 (73.39–543.62) and €42.74 (23.89–61.77) to avoid nausea. Conclusion Both patients and physicians in Spain and Portugal are willing to pay for the health benefits associated with improved diabetes treatment, the most important being to avoid hypoglycemia and gaining weight. Decreased cardiovascular risk and weight reduction became the third most valued attributes for physicians and patients, respectively.
High-Precision Measurement of Sine and Pulse Reference Signals Using Software-Defined Radio

This paper addresses simultaneous high-precision measurement and analysis of generic reference signals by using inexpensive commercial off-the-shelf software-defined radio hardware. Sine reference signals are digitally downconverted to baseband for the analysis of phase deviations. Hereby, we compare the precision of the fixed-point hardware digital signal processing chain with a custom single instruction multiple data x86 floating-point implementation. Pulse reference signals are analyzed by a software trigger that precisely locates the time where the slope passes a certain threshold. The measurement system is implemented and verified using the Universal Software Radio Peripheral (USRP) N210 by Ettus Research LLC. Applying standard 10 MHz and 1 PPS reference signals for testing, a measurement precision (standard deviation) of 0.36 and 16.6 ps is obtained, respectively. In connection with standard PC hardware, the system allows long-term acquisition and storage of measurement data over several weeks. A comparison is given to the dual-mixer time difference and time interval counter, which are state-of-the-art measurement methods for sine and pulse signal analysis, respectively. Furthermore, we show that our proposed USRP-based approach outperforms measurements with a high-grade digital sampling oscilloscope.
Analytical and T-CAD modeling of pentacene thin-film transistors

Many researches report that the mobility in organic material is dependent on not only the gate field but also the grain size. There is also some evidence to prove that the gate length is strongly related to the carrier mobility. We construct both the analytical model of organic thin film transistor and the large signal circuit model designed by T-CAD to fit the measured I DS - V DS curves. We first apply basic I DS - V DS equations in both triode and saturation regions with mobility μ best fitted to measured I-V curves. The "best-fitted" μ increases with the gate length, and is related to the increase of total channel resistance due to the presence of small grains size of pentacene next to source/drain electrodes. We then use the Advanced Design System software to design the large signal circuit model. Similar to the MOSFET, we add the additional parameters to fit the I DS - V DS curves, ex: Rgd, Rgs, and Rp. Here, Rgd. With the circuit simulation, we find that Rgd presents the leakage current from gate to source, and it affects the slope of curves in the saturation region in the I DS - V DS curves. The equivalent circuit can fit the I DS - V DS curves very well with the proper parameter set.
Interactive Revision Exploration using Small Multiples of Software Maps

: To explore and to compare different revisions of complex software systems is a challenging task as it requires to constantly switch between different revisions and the corresponding information visualization. This paper proposes to combine the concept of small multiples and focus+context techniques for software maps to facilitate the comparison of multiple software map themes and revisions simultaneously on a single screen. This approach reduces the amount of switches and helps to preserve the mental map of the user. Given a software project the small multiples are based on a common dataset but are specialized by speciﬁc revisions and themes. The small multiples are arranged in a matrix where rows and columns represents different themes and revisions, respectively. To ensure scalability of the visualization technique we also discuss two rendering pipelines to ensure interactive frame-rates. The capabilities of the proposed visualization technique are demonstrated in a collaborative exploration setting using a high-resolution, multi-touch display.
Numerical Analysis of Wavy Interface Formation and Successive Temperature Change in Magnetic Pulse Welded Al/Cu Joint

Magnetic pulse welding (MPW) which is one of the impact welding methods is suitable for a wide variety of combinations of similar and dissimilar metals. The flyer plate is accelerated by electromagnetic force and collided to the parent plate. A characteristic wavy interface is formed. The impact velocity and impact angle of the flyer plate during impact are important parameters which affect the interface morphology. In the case of dissimilar metals (e.g. Al/Cu, Al/Fe), the intermediate layer (such as intermetallic compound (IMC)) is formed by wavy interface formation and local temperature increase. The intermediate layer often decreases the bonding strength. Wavy interface formation mechanism and temperature increase at the joint interface should be investigated in order to obtain the dissimilar metal joint with high bonding strength. In this study, the impact velocity and impact angle of the flyer plate were obtained by using ANSYS Emag-Mechanical. Based on the obtained impact velocity and impact angle of the flyer plate in the MPW, the wavy interface formation and temperature change were reproduced by using ANSYS Autodyn for solving non-liner dynamics problems. Al sheets and Cu sheets were joined by the MPW. The joint interface was observed by OM and SEM and compared to the simulation result.
A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea‐Predominant Irritable Bowel Syndrome

We aimed to evaluate clinical symptoms in diarrhea predominant irritable bowel syndrome (IBS‐D) receiving berberine hydrochloride in a randomized double‐blind placebo‐controlled clinical trial. Overall, 196 patients with IBS‐D were recruited for this study; consequently, 132 patients randomized to receive daily 400 mg of berberine hydrochloride, delivered twice daily or placebo for 8 weeks followed by a 4‐week washout period. After a 2‐week run‐in period, diarrhea, abdominal pain, urgent need for defecation frequency and any adverse events were recorded daily. Prior to administration of the medication and after completing the treatment, assessment of IBS symptom scores, depression and anxiety scale scores and the IBS scale for quality of life (QOL) was carried out. The effects of berberine hydrochloride on IBS‐D, defined by a reduction of diarrhea frequency (P = 0.032), abdominal pain frequency (P < 0.01) and urgent need for defecation frequency (P < 0.01), were significantly more pronounced in the berberine group than the placebo group in the 8 weeks of treatment. A trend of improvement (P < 0.05) was observed with berberine hydrochloride for IBS symptom score, depression score and anxiety score and the IBSQOL, compared with placebo. At last, berberine hydrochloride was well tolerated. So we concluded that berberine hydrochloride is well tolerated and reduces IBS‐D symptoms, which effectively improved patients QOL. Copyright © 2015 John Wiley & Sons, Ltd.
Error detection scheme of smart DDS for naval combat system

This paper proposes a scheme to detect middleware errors in Smart DDS (Data Distribution Service) in a NCS (naval combat system). NCS includes various devices such as monitoring tool, search radar based-on Smart DDS. Because of this construct, it is unable to handle rapidly problems communicating when they occur in wartime situation. To handle quickly the problems, this study can detect the problems in real-time using interface of Smart DDS layers. Previous detection schemes are unsuitable on urgent wartime situation because they has several unnecessary requests. In this paper, proposed scheme detects rapidly problems using the Smart DDS layers interface. Simulation results show that proposed scheme reduces the latency for detecting problems compared with existing debugging tools, and it is expected to improve the recovery performance of NCS.
Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir

It is discovered that sustained cytosolic drug release at a sufficient concentration is an effective mechanism to circumvent multidrug resistance and consequently enhance antitumor drug efficacy. It is showed that a simple way to enable this mechanism is to reach an intracellular kinetic balance of the drug movement between the drug released from the carrier into the cytosol and the one removed from the cell interior. By adopting nanoparticle (NP) as the drug carrier, a reservoir of drug can be maintained inside the cells upon effective cellular uptake of these NPs via endocytosis. This study shows that gradual release of the drug from the NP carrier provides a feasible scheme for sustained drug release in cells, resulting in relatively stable cytosolic drug concentration level, particularly in the drug resistant case. By implementing an “optical switch” with light irradiation on photosensitizer in the same nanoparticle carrier, cytosolic drug release is further promoted, which increases cytosolic drug concentration with good concentration retention. Enhanced drug efficacy in drug sensitive as well as resistant models is demonstrated both in vitro and in vivo. Such a mechanism is shown to efficiently circumvent multidrug resistance, and at the same time largely reduce the systemic toxicity of the anticancer drug.
Fog-Aided Wireless Networks for Content Delivery: Fundamental Latency Tradeoffs

A fog-aided wireless network architecture is studied in which edge nodes (ENs), such as base stations, are connected to a cloud processor via dedicated fronthaul links while also being endowed with caches. Cloud processing enables the centralized implementation of cooperative transmission strategies at the ENs, albeit at the cost of an increased latency due to fronthaul transfer. In contrast, the proactive caching of popular content at the ENs allows for the low-latency delivery of the cached files, but with generally limited opportunities for cooperative transmission among the ENs. The interplay between cloud processing and edge caching is addressed from an information-theoretic viewpoint by investigating the fundamental limits of a high signal-to-noise-ratio metric, termed normalized delivery time (NDT), which captures the worst case coding latency for delivering any requested content to the users. The NDT is defined under the assumptions of either serial or pipelined fronthaul-edge transmission, and is studied as a function of fronthaul and cache capacity constraints. Placement and delivery strategies across both fronthaul and wireless, or edge, segments are proposed with the aim of minimizing the NDT. Information-theoretic lower bounds on the NDT are also derived. Achievability arguments and lower bounds are leveraged to characterize the minimal NDT in a number of important special cases, including systems with no caching capabilities, as well as to prove that the proposed schemes achieve optimality within a constant multiplicative factor of 2 for all values of the problem parameters.
Postpartum family planning integration with maternal, newborn and child health services: a cross-sectional analysis of client flow patterns in India and Kenya

Objectives Maternal, newborn and child health (MNCH) services represent opportunities to integrate postpartum family planning (PPFP). Objectives were to determine levels of MNCH–family planning (FP) integration and associations between integration, client characteristics and service delivery factors in facilities that received programmatic PPFP support. Design and setting Cross-sectional client flow assessment conducted during May–July 2014, over 5 days at 10 purposively selected public sector facilities in India (4 hospitals) and Kenya (2 hospitals and 4 health centres). Participants 2158 client visits tracked (1294 India; 864 Kenya). Women aged 18 or older accessing services while pregnant and/or with a child under 2 years. Interventions PPFP/postpartum intrauterine device—Bihar, India (2012–2013); Jharkhand, India (2009–2014); Embu, Kenya (2006–2010). Maternal, infant and young child nutrition/FP integration—Bondo, Kenya (2011–2014). Primary outcome measures Proportion of visits where clients received integrated MNCH–FP services, client characteristics as predictors of MNCH–FP integration and MNCH–FP integration as predictor of length of time spent at facility. Results Levels of MNCH–FP integration varied widely across facilities (5.3% to 63.0%), as did proportion of clients receiving MNCH–FP integrated services by service area. Clients travelling 30–59 min were half as likely to receive integrated services versus those travelling under 30 min (OR 0.5, 95% CI 0.4 to 0.7, P<0.001). Clients receiving MNCH–FP services (vs MNCH services only) spent an average of 10.5 min longer at the facility (95% CI −0.1 to 21.9, not statistically significant). Conclusions Findings suggest importance of focused programmatic support for integration by MNCH service area. FP integration was highest in areas receiving specific support. Integration does not seem to impose an undue burden on clients in terms of time spent at the facility. Clients living furthest from facilities are least likely to receive integrated services.