Miracle-dz/UniFAR-FTUs huggingface dataset:
Ethanol inhibits in‐vitro metabolism of nifedipine, triazolam and testosterone in human liver microsomes

Although extended exposure to ethanol induces CYP3A metabolism in‐vivo, the acute effects of ethanol on CYP3A metabolism have not been fully evaluated in‐vitro. We assessed the effect of ethanol on CYP3A‐mediated biotransformation using human liver microsomes in‐vitro with three prototypic CYP3A‐mediated reactions: nifedipine to oxidized nifedipine, triazolam to its 1‐hydroxy (1‐OH TRZ) and 4‐hydroxy (4‐OH TRZ) metabolites, and testosterone to 6β‐hydroxytestosterone (6β‐OH TST). Ethanol inhibited metabolism of nifedipine (oxidized nifedipine IC50 3 mg dL−1, where the IC50 value is the inhibitor concentration corresponding to a 50% reduction in metabolite formation velocity), triazolam (1‐OH TRZ IC50 1.1 mg dL−1, 4‐OH TRZ IC50 2.7 mg dL−1) and testosterone (6β‐OH TST IC50 2.4 mg dL−1). The inhibitory potency of ethanol was similar for the three substrates representing the three hypothetical CYP3A substrate categories. The IC50 values obtained were lower than clinically relevant blood alcohol concentrations. In conclusion, ethanol is an inhibitor of human CYP3A metabolism and may contribute to clinically important interactions.
ECO method and object grammars : two methods for the enumeration of combinatorial objects

Cette these se situe dans le domaine de la combinatoire enumerative et bijective. La these commence par une introduction sur les structures et les methodes qui sont ensuite utilisees. Puis elle se divise en deux parties. La premiere analyse des problemes lies a ECO. En particulier, on analyse le probleme de monter des regles de succession equivalentes. Plus precisement, on introduit des classes de regles equivalentes et on demontre l’equivalence en utilisant la methode ECO. Dans le chapitre 3, on montre comment determiner des regles de succession associees a une grande classe de recurrences litteraires positives croissantes. Puis on montre comment il est possible de decrire des recurrences lineaires au moyen de regles de succession negatives. Dans la seconde partie on etudie les relations entre les grammaires d’objets et la methode ECO. En particulier, dans le chapitre 4, on montre comment on peut passer d’une grammaire d’objet a un ECO systeme associe selon un parametre lineaire. Dans le chapitre 5 ce resultat est etendu au cas des parametres q-lineaire pour les grammaires unidimensionnelles. Dans le chapitre 6 on obtient, d’une facon quasi-automatique, une grammaire pour la classe des polyominos convexes a partir d’un ECO systeme pour cette classe.
Studies on Pareto-based multi-objective competitive coevolutionary dynamics

Competitive coevolutionary algorithms are stochastic population-based search algorithms. To date, most competitive coevolution research has been carried in the domain of single-objective optimization. We propose a novel competitive coevolutionary framework to explore Pareto-based multi-objective competitive coevolution. This framework utilizes the hypervolume indicator and fitness sharing mechanism to address disengagement and over-specialisation issues. A diversity-driven evolutionary selection scheme is utilized to deal with the loss of fitness gradient problem. Several series of experiments are conducted using multi-objective two-sided competitive games. The results suggest that Pareto-optimal solutions can effectively be found using our proposed coevolutionary framework.
GENETIC ASSESSMENT OF SEA TURTLES FORAGING AGGREGATIONS OF BONAIRE , NETHERLANDS ANTILLES Final Report submitted to Sea Turtle Conservation

As a result of dispersal and migratory behavior, sea turtles establish a complex interconnection between their original natal rookeries and their developmental and foraging grounds. Elucidating this interconnection is of vital importance as it provides a regional perspective of conservation priorities and initiatives to recover and maintain their populations. In addition it provides important clues to gain a better understanding of the migratory behavior of sea turtles and the factors influencing their spatial and temporal distribution. In this study, we assessed the genetic variation of a section of the mtDNA control region to investigate the genetic diversity and origin of the green sea turtle and hawksbill sea turtle foraging aggregations (FAs) of Bonaire, Netherlands Antilles. Furthermore, we conducted a mixed stock analysis with a hierarchical Bayesian approach to estimate the most likely future contribution of the Bonaire FAs to adult recruitment of Caribbean and Atlantic nesting rookeries. After analyzing 169 individuals (hawksbills=75, greens=94) a relatively high genetic diversity characterizing both aggregations was observed, with the green aggregation exhibiting the highest genetic diversity so far observed for a foraging aggregation. Evidence was obtained that confirms the cosmopolite character of the FAs with individuals exclusively from Caribbean rookeries recruiting to the hawkbill foraging grounds. Interestingly, a contribution of rookeries from South Atlantic and probable from West Africa was suggested for the green turtle foraging ground. This confirms the migratory capabilities of the green sea turtles and provides the framework to further test hypotheses about the mechanism influencing such long-distance dispersal. Results from this study not only confirm the regional connectivity established between the Island of Bonaire and the rest of the Caribbean nesting rookeries but also reveals that recruitment from rookeries far as Africa exists and highlights the importance of a regional collaboration to conserve these areas as they represent the future of reproductive recruitment.
FACTORS INFLUENCING E-COMMERCE ADOPTION AMONG MALAY WOMEN ENTREPRENEURS IN KUCHING SARAWAK

Nowadays, women entrepreneurs have become part of the important factor in the world of entrepreneurship in terms of economic development contributions and social inclusion. Moreover, the ability of small and medium-sized enterprises (SMEs) to foster innovation, experimentation, and adaptation in the business environment is crucial for countries undergoing radical transformation. 140 respondents were involved in this survey which was conducted for two weeks and the data from the questionnaires were analysed and computed by using mean score, regression and correlation. This paper aims to investigate the factors that affect the adoption of E-Commerce by Malay women entrepreneurs in Kuching Sarawak. Variables are categorized based on different E-Commerce adoption context which include technological factors, organizational factors and environmental factors with additional of benefits and barriers of E-Commerce adoption are expected to affect the adoption of ECommerce. Quantitative approach was used for this study. The findings indicate that perceived relative advantage was the most influencing factor in the adoption of E-Commerce among Malay women entrepreneurs in Kuching Sarawak. Furthermore, the finding from this study complements several prior studies. Only perceived relative advantage, cost and competitive pressure has the ability in predicting the level of E-Commerce adoption. This study also highlights that perceived benefit from adopting ECommerce by Malay women entrepreneurs to be imminent as it provides access to new markets. This study also shows that Malay women entrepreneurs in Kuching Sarawak have yet to utilize E-Commerce technologies despite having acknowledged perceiving the benefits that can be obtained by adopting ECommerce
The influence of open innovation on domestic sales in Brazilian industry: an analysis of the Innovation Survey 2014 based on structural equation modeling

This research analyzes the influence of open innovation strategy on the participation of innovations in the context of domestic sales in the Brazilian industrial sector. To perform this analysis, available data were extracted from the PINTEC 2014 Innovation Survey. In applying structural equation modeling (SEM), we found that open innovation has a direct and positive influence on the sales of new products and services in the domestic market, albeit with a modest effect. The same analysis was applied to the relationship between open innovation and domestic sales, which was found to be mediated by the impacts caused by innovation. In other words, open innovation influences the participation of innovations in domestic sales, both directly and indirectly. Besides verifying the relationship among the concepts presented in this study, it was possible to estimate their effects and make a realistic contribution to the debate, emphasizing that innovation, despite being an essential condition, is not sufficient to generate strong impacts on domestic sales, according to PINTEC 2014 respondents. To achieve high impacts, it is necessary to continuously promote and support innovation for the generation of growth.
Simulation Analysis of Multiple BP Decoding Algorithm and FFT-BP Decoding Algorithm

In order to solve the problem that the original decoding algorithm of multi-band LDPC codes is high and is not conducive to hardware implementation, two simplified decoding algorithms for multi-band LDPC codes are studied: the reliability propagation based on fast Fourier transform Code algorithm (FFT-BP) and log-BP decoding algorithm based on logarithmic operations. The simulation results show that the FFT-BP decoding algorithm is more convenient and efficient.
Correlation between esterase electrophoretic types and capsular polysaccharide types 5 and 8 among methicillin-susceptible and methicillin-resistant strains of Staphylococcus aureus

The relationship between capsular polysaccharide types 5 and 8 and esterase electrophoretic types (zymotypes) in 160 French clinical isolates of Staphylococcus aureus was studied. Methicillin-susceptible strains of capsular types 5 and 8 were represented by 11 zymotypes, indicating a high polymorphism. Methicillin-resistant strains were mainly distributed in only two distinct populations. The predominant population was represented by strains of zymotype 6 and capsular type 5, and the second population was represented by strains of zymotype 14 and capsular type 8.
Some Correlates of Conceptual Complexity

Scores on 3 measures of conceptual complexity were related to a number of biographic and demographic variables. Age, sex, GPA, and birth order were generally unrelated to complexity as were differences among formal religious denominations and Canadian political party preferences. However, complexity scores were generally lower for (1) Ss reporting religious affiliations vs non-affiliates, (2) Ss voting for a party rather than the man, (3) Ss enrolled in the Faculty of Education vs those in Arts and Science, and (4) Ss enrolled in pre-professional training programs vs those working towards the B.A. degree.
Characterization of the single-subunit oligosaccharyltransferase STT3A from Trypanosoma brucei using synthetic peptides and lipid-linked oligosaccharide analogs

Abstract The initial transfer of a complex glycan in protein N-glycosylation is catalyzed by oligosaccharyltransferase (OST), which is generally a multisubunit membrane protein complex in the endoplasmic reticulum but a single-subunit enzyme (ssOST) in some protists. To investigate the reaction mechanism of ssOST, we recombinantly expressed, purified and characterized the STT3A protein from Trypanosoma brucei (TbSTT3A). We analyzed the in vitro activity of TbSTT3A by synthesizing fluorescently labeled acceptor peptides as well as lipid-linked oligosaccharide (LLO) analogs containing a chitobiose moiety coupled to oligoprenyl carriers of distinct lengths (C10, C15, C20 and C25) and with different double bond stereochemistry. We found that in addition to proline, charged residues at the +1 position of the sequon inhibited glycan transfer. An acidic residue at the −2 position significantly increased catalytic turnover but was not essential, in contrast to the bacterial OST. While all synthetic LLO analogs were processed by TbSTT3A, the length of the polyprenyl tail, but not the stereochemistry of the double bonds, determined their apparent affinity. We also synthesized phosphonate analogs of the LLOs, which were found to be competitive inhibitors of the reaction, although with lower apparent affinity to TbSTT3A than the active pyrophosphate analogs.
THE DEFENSIBLE SPACE CONCEPT IN NEIGHBOURHOOD PARK CASE STUDY: TAMAN TASIK PUCHONG PERDANA, SELANGOR, MALAYSIA

Open space can contribute to the overall wellbeing of life by providing social and recreational focal points. However, open space may also be associated with undesirable qualities of a place such as crime activities that affect negatively its quality and the surrounding. Thus, to create a safe and comfort open space area, the defensible space concept is seen as an important approach to deter crime from occurring and to sustain the safety environment. Therefore, this research objective is to investigate whether the elements of the defensible space concept; territoriality, surveillance, and image, may be used in the planning of neighbourhood park. A study was carried out at Taman Tasik Puchong Perdana, Selangor by using a questionnaire survey to collect information from the visitors. The findings show that the defensible space concept with all the three elements was not implemented, which further may lead to the crime activities in the neighborhood park.
In Vitro Antimicrobial Activity and Chemical Composition of Two Essential Oils and Eugenol from Flower Buds of Eugenia caryophyllata

RESEARCH ARTICLE In Vitro Antimicrobial Activity and Chemical Composition of Two Essential Oils and Eugenol from Flower Buds of Eugenia caryophyllata Natalija Atanasova-Pancevska, Jane Bogdanov and Dzoko Kungulovski Department of Microbiology and Microbial Biotechnology, Institute of Biology, Faculty of Natural Sciences and Mathematics, University “Ss. Cyril and Methodius”, Arhimedova 3, 1000 Skopje, Macedonia Institute of Chemistry, Faculty of Natural Sciences and Mathematics, University “Ss. Cyril and Methodius”, Arhimedova 3, 1000 Skopje, Macedonia
Impact of external and internal factors on management accounting practices: a study of Pakistan

Purpose The accounting system plays an important role in the company’s organizational structure. The purpose of this paper is to demonstrate that the integration of management accounting practices is subject to coordination between external and internal factors and accounting management practices. Design/methodology/approach Therefore, the authors move to the contingency model to determine the most significant external “unexpected factors” that explain the introduction of management practices for the management of the various stages of development. The exploratory study examines a sample of Pakistani companies from various sectors. Findings This study reveals that the main factors of uncertainty that affect the organizational structure, environmental uncertainty, advanced production technology, just-in-time method strategy, integrated management of quality and structure findings reveal that MAP affected all process and changes all system in simple to complex system in Pakistani’s industries. Practical implications This study is to acquisition the impact of external factors on management accounting practices, to find the impact of internal factors on management accounting practices, to establish the management accounting practices undertaken by the companies in Pakistan. Originality/value The study contributes to the literature by enhancing our understanding for the impact of external and internal factors on management accounting practices in Pakistan.
A self-learning approach for pan-sharpening of multispectral images

Due to the importance of high-resolution multi-spectral (HRM) images in many remote sensing applications, pan-sharpening techniques have been proposed to increase the spatial resolution of a low-resolution multi-spectral (LRM) image using a high-resolution panchromatic (HRP) image. In this paper, we propose a self-learning approach to pan-sharpen the LRM images. Many structures in a natural image redundantly tend to repeat in the same scale as well as different scales. These similar structures in different levels can be used to reconstruct the HRM bands with more details; in this perspective, we can construct the HRM data from the available HRP and LRM data by using self-similarity in a multi-scale procedure. The proposed method has been applied on GeoEye-1 data and DEIMOS-2 data, and then fused images compared with some popular and state-of-the-art methods in terms of several assessment indexes. The experimental results demonstrate that the proposed method can retain spectral and spatial information of the source images efficiently.
Construcción de índices ponderados multicriterio con información ordinal

El objetivo de este trabajo es establecer una metodologia que permita construir indices para la evaluacion de un conjunto de unidades, cuando se dispone de las valoraciones de estas con respecto a varios criterios medidos en una escala ordinal. Con objeto de reflejar lo mas fielmente posible los aspectos evaluados, en los indices compuestos que proponemos se incorpora la informacion disponible sobre la importancia relativa de los distintos criterios y sobre la importancia de las distintas categorias ordinales. Se ilustra el procedimiento con un analisis de valoraciones realizadas por los alumnos de las distintas Titulaciones de la Universidad Pablo de Olavide de Sevilla.
Sculpting an organisational field

Organisational fields in the aggregate constitute a recognized area of institutional life. In Turkey, Sabanci University (SU) has shaped the emerging organisational field of “technology-based academic entrepreneurship” significantly. SU has founded the second technology transfer office, Research and Graduate Policy Directorate (RGP), in Turkey. In essence, RGP acts as an interface between academic and the business world according the demands of the business world with the research of the academic world. However, RGP goes further and founds the first technology commercialisation company, Inovent, providing business view to researchers and help them get patents, found companies, and transfer their knowledge to business world. Furthermore, Golden Horn Ventures, second venture capital firm spins-out from Inovent. Subsequently, other universities started founding technology transfer offices and companies like Inovent. Overall, this paper is an explorative research, which will provide the detailed case of the shaping of an organisational field in a developing country by a dominant actor. In other words, the role of SU in creating technology-based academic entrepreneurship in Turkey.
Evaluation of the State-Wide Implementation of an Allied Health Workforce Redesign System: Utilisation of the Calderdale Framework

Background: Increasing demand for allied health services is driving workforce redesign towards greater productivity within budgetary constraints. To date, there has been limited research into workforce redesign tools at an organisational level. The aim of this article was to evaluate an implementation of The Calderdale Framework for state-wide service delivery workforce redesign within allied health settings across Queensland. Method: A multi-phase methodology with mixed methods of data collection was used. This included analysis of documents, staff surveys, and semi-structured, in-depth interviews with staff from work units utilising the Framework across the state. Findings: The primary mechanisms for implementation were staff training and provision of centralised resources. Across the state, all health services engaged in training and most completed associated workforce redesign projects. However, the number and type of projects varied across the state as did the successful projects. Feedback from staff indicated the structured nature of the framework was viewed positively, but was time intensive to perform. Local contextual factors heavily influenced workforce redesign success. Conclusion: Key factors pertaining to state-wide workforce redesign include: providing coordinated and centralised systems to support staff, ensuring adequate training, prioritising the development of key local staff, and proactively managing local contextual factors.
Regulation of Phospholipase D2 by H2O2 in PC12 Cells

Abstract: Phospholipase D2 (PLD2) is expressed in brain andinhibited by synuclein, which is involved in Parkinson's and Alzheimer'sdiseases. However, the activation mechanism of PLD2 in neuronal cells has notbeen defined clearly. Hydrogen peroxide (H2O2) playsroles in the neurodegenerative diseases and also acts as a second messenger ofvarious molecules such as nerve growth factor. To study regulation mechanismsof PLD2 by H2O2 in neuronal cells, we have made stablePC12 cell lines expressing PLD2 (PLD2‐PC12 cells). H2O2treatment stimulated PLD activity in PLD2‐PC12 cells in a dose‐ andtime‐dependent manner. This activation was inhibited by the treatment withprotein kinase C (PKC) inhibitors or by depletion of PKCα, ‐δ, and‐ε. Phorbol ester markedly activated PLD2. Co‐treatment with phorbolester and H2O2 did not show an additive effect.Chelation of extracellular calcium substantially blocked theH2O2‐induced activation of PLD2. A calcium ionophoreinduced PLD2 activation in a PKC‐dependent manner. Protein‐tyrosine kinaseinhibitors inhibited H2O2‐induced PLD activationslightly. These data indicate that H2O2 can activatePLD2 in PC12 cells and that this activation is largely dependent on PKC andCa2+ ions and minimally dependent on tyrosine phosphorylation.
Inherently Lower-Power High-Performance Superscalar Architectures

In recent years, reducing power has become an important design goal for high-performance microprocessors. This work attempts to bring the power issue to the earliest phases of microprocessor development, in particular, the stage of defining a chip microarchitecture. We investigate power-optimization techniques of superscalar microprocessors at the microarchitecture level that do not compromise performance. First, major targets for power reduction are identified within microarchitecture, where power is heavily consumed or will be heavily consumed in next-generation superscalar processors. Then, a new, energy-efficient version of a multicluster microarchitecture is developed that reduces energy the identified critical design points with minimal performance impact. A methodology is developed for energy-performance optimization at the microarchitecture level that generates, for a microarchitecture, a set of energy-efficient configurations, forming a convex hull in the power-performance space. Detailed simulation of the baseline and proposed multicluster architectures has been performed using the developed optimization methodology. A comparison of the two microarchitectures, both optimized for energy efficiency, shows that the multicluster architecture is potentially up to twice as energy efficient for wide issue processors, with an advantage that Grows with the issue width. Conversely, at the same power dissipation level, the multicluster architecture supports configurations with measurably higher performance than equivalent conventional designs.