Miracle-dz/UniFAR-FTUs huggingface dataset:
Reconfigurable Wireless Power Transfer Systems for Distance Adaptation

High efficiency power transfer in a magnetically coupled resonant wireless power transfer (MCR-WPT) system is only happened at a specific distance. In most applications, the distance between the transmitter and the receiver could be changed. To overcome this boundary, a reconfigurable three coil wireless power transfer system is proposed in this paper to maintain high power transfer efficiency over a long distance. The repeater coil consists of switches which are used to adjust the coupling coefficient and improve the transmission quality according to the change of distance between the transmitter and receiver. The principle of this reconfigurable structure is explained with the theoretical analysis and verified with experimental measurements.
Plant-based vaccines for animals and humans: recent advances in technology and clinical trials

It has been about 30 years since the first plant engineering technology was established. Although the concept of plant-based pharmaceuticals or vaccines motivates us to develop practicable commercial products using plant engineering, there are some difficulties in reaching the final goal: to manufacture an approved product. At present, the only plant-made vaccine approved by the United States Department of Agriculture is a Newcastle disease vaccine for poultry that is produced in suspension-cultured tobacco cells. The progress toward commercialization of plant-based vaccines takes much effort and time, but several candidate vaccines for use in humans and animals are in clinical trials. This review discusses plant engineering technologies and regulations relevant to the development of plant-based vaccines and provides an overview of human and animal vaccines currently under clinical trials.
Enhanced tissue differentiation in the developing mouse brain using magnetic resonance micro‐histology

Purpose: Worldwide efforts to understand developmental processes demand new high‐resolution 3D imaging methods to detect the consequences of gene function in embryo development and diseases. Encouragingly, recent studies have shown that MRI contrast agents can highlight specific tissue structures in ex vivo adult mouse brains. MR imaging of mouse embryos is currently limited by a lack of tissue staining capabilities that would provide the flexibility and specificity offered by histological stains conventionally used for mouse embryo phenotyping.
Income Distribution on NPLs: A Panel Data Analysis for the Industrialized World

In the present paper an empirical analysis will point out that as income distribution worsens, then the NPLs go up and banks will tend to face losses. Our sample covers all industrialized world. Data are taken from World Bank and Eurostat. The elaboration of these panel data is made feasible by means of the Eviews software package.
HSV-1 Infection Modulates the Radioresponse of a HPV16-positive Head and Neck Cancer Cell Line.

BACKGROUND The combined effects of Human papillomavirus (HPV) and Herpes simplex type 1 (HSV-1) infections and their effects on cancer cell radioresistance are unexplored. MATERIALS AND METHODS An HPV16-positive hypopharyngeal carcinoma cell line (UD-SCC-2) was infected with wt-HSV-1 at low multiplicity of infection (MOI) and irradiated with 2 Gy at 24 h postinfection. Viability assays and quantitative reverse-transcriptase PCR for HPV16 E6, E7, nuclear factor kappa B1, B-cell CLL/lymphoma 2 (BCL2), and caspases 3, 8 and 9 at 24, and 72 h, as well as immunocytochemistry for BCL2, caspase 3, cyclin E, mouse double minute 2 homolog (MDM2), HSV-1 and Ki-67 were performed at 144 h postirradiation. RESULTS At 144 h, cell viability was significantly lowered by irradiation only in uninfected cells. Infection combined with irradiation resulted in increased expression of E6, E7, BCL2 and NF-κB1 at 144 h. Simultaneously, E6 and E7 were down-regulated in non-irradiated infected cells. Irradiation and infection with 0.00001 MOI separately up-regulated caspase 3 but infection with 0.0001 MOI halved its expression in irradiated cells. CONCLUSION HSV-1 infection modulates radioresistance of HPV16-positive hypopharyngeal carcinoma cells.
Finite-Width Magnetic Mirror Models of Mono and Dual Coils for Wireless Electric Vehicles

Improved magnetic mirror models (IM3) for mono and dual coils with a finite width and infinite permeability are proposed in this paper. By introducing a mirror current, which is located at the same distance from a source current but with a smaller magnitude than the source current, the magnetic flux density of the mono and dual coils can be determined in a closed form. The ratio of the mirror current and source current is identified as a function of the width of the core plate and the distance between the source current and core plate, as rigorously derived from finite-element method simulations. Applying the proposed IM3 to the mono and dual coils used for wireless electric vehicles, the magnetic flux density over an open core plate is analyzed and its maximum points on the plate are found, which is crucial in the design of the coils to avoid local magnetic saturation. Furthermore, the magnetic flux density when a pick-up core plate is positioned over a primary core plate is also analyzed by introducing successive mirror currents. The proposed magnetic mirror models were extensively verified by experiments as well as site tests, showing quite promising practical usefulness.
High-performance liquid chromatographic determination of tanshinones in the roots of Salvia miltiorrhiza and related traditional chinese medicinal preparations.

PURPOSE This paper describes a validated high-performance liquid chromatographic method to quantitate four tanshinones as markers; dihydrotanshinone I, cryptotanshinone, tanshinone I and tanshinone IIA for use in the quality control of the roots of Salvia miltiorrhiza and its related traditional Chinese medicinal preparations. METHODS Separation was achieved using a Zorbax Extend C18 reserved-phase column (5microm, 250*4.6mm) at 20 degrees with a gradient mixture of deionized water and acetonitrile at a flow rate of 1.2ml/min. RESULT The limits of quantitation were 0.13, 0.08, 0.06 and 0.05microg/ml for dihydrotanshinone I, cryptotanshinone, tanshinone I and tanshinone IIA, respectively. This method provided good reproducibility and sensitivity for the quantification of four tanshinones with overall RSD values for intra-day and inter-day precision and accuracy better than 3.8% and higher than 94.9%, respectively. The recovery of the method was 95.4-104.4% for all the tanshinones and showed good linearity (r>0.9998) over a relatively wide concentration range. CONCLUSIONS This assay was successfully applied to the determination of four tanshinones in the roots of Salvia miltiorrhiza and its related traditional Chinese medicinal preparations. The results indicated that the HPLC assay could be readily utilized as a quality control method for the roots of Salvia miltiorrhiza and its related traditional Chinese medicinal preparations.
Rapid Quantification of Gabapentin, Pregabalin, and Vigabatrin in Human Serum by Ultraperformance Liquid Chromatography With Mass-Spectrometric Detection

Background:Gabapentin (GBP), pregabalin (PRG), and vigabatrin (VIG) are used for the prevention and treatment of epileptic seizures. The developed method was applied to samples from subjects participating in a pharmacokinetic study of GBP. Methods:Sample pretreatment consisted of adding 20 &mgr;L of trichloroacetic acid (30%; vol/vol) and 200 &mgr;L of GBP-d4 in acetonitrile as an internal standard to 20 &mgr;L of serum. Chromatographic separation was performed on an Acquity separation module using a Kinetex RP18 column. The aqueous and organic mobile phases were 2 mM ammonium acetate supplemented with 0.1% formic acid in water and acetonitrile, respectively. The detection by a tandem quadrupole mass spectrometer, operating in the positive mode using multiple reaction monitoring, was completed within 2 minutes. Results:The method was linear over the range of 0.03–25 mg/L for GBP, 0.03–25 mg/L for PRG, and 0.06–50 mg/L for VIG. The between- and within-run accuracies ranged from 90% to 107%. The between- and within-run imprecisions of the method were <10%. Stability data show no significant decrease of the analytes. A relative matrix effect of −1%, 0.2%, and −5% was determined for GBP, PRG, and VIG, respectively. Conclusions:A simple and sensitive ultraperformance liquid chromatography–tandem mass spectrometry method was developed and validated for the simultaneous quantification of GBP, PRG, and VIG in human serum. The reported method provided the necessary linearity, precision, and accuracy to allow the determination of GBP, PRG, and VIG for therapeutic drug monitoring and clinical research purposes.
Paternal age predicts offspring chances of marriage and reproduction

Mutation‐selection balance theory proposes that a balance of forces between constantly arising mildly harmful mutations and selection causes variation in genetic configuration and phenotypic condition. As mutations are predominantly deleterious, the entry of variation due to mutations is kept at low frequencies by selection. It has recently been demonstrated that nearly all de novo mutation are caused by paternal age.
Responsible innovation among academic spin-offs: How responsible practices help developing absorptive capacity

Responsible innovation (RI) among technology-based start-ups has received little attention, while these firms are known to operate on the edges of what is socially desirable or ethically acceptable. In this paper we develop a conceptual model that captures the RI practices among 61 academic spin-offs and investigate how it affects the capacity of the firm to absorb external knowledge to better the exploitation of the innovation. The findings indicate that potential absorptive capacity is increased by both stakeholder engagement and social responsiveness, while realized absorptive capacity is moderately increased through social responsiveness. Remarkable is the finding that the extent that sustainability practices resonate in the start-ups operations does have a negative effect on the potential absorptive capacity. These results provide insight in the way in which start-ups adopt a RI philosophy to their innovation process and help to better understand how they learn and acquire external knowledge to increase the acceptance of their innovations. The findings provide clear recommendations for entrepreneurs and policymakers in the field of entrepreneurship and innovation.
Optimal Speed of Transition under Shrinking Labor Force and Uncertainty

After the start of transition, in Central European Economies the restructuring process of large state enterprizes was accompanied by high unemployment all through the ’90s. Social policy expenditures, particularly targeted to the non-employed, grew faster than expected due to the need to flnance the out-of-labor categories. The reallocation of workers from the state to the private sector called for the establishment of an adequate social safety net. In this paper, unemployment dynamics, speed of transition and non-employment policies are modelled based on the assumption that the labor force is shrinking over time. Dismissed workers have the opportunity to choose an outsideoption, i.e. an alternative to the labor force participation. Individual uncertainty is assumed in a flrst phase of the model, while aggregate uncertainty generating opposition to restructuring is modelled in a second phase. The model predicts a slow down of the speed of transition. Starting from 1992, after the reforms concerning Passive Labor ⁄ A previous version of this paper was circulated under the title ’Speed of Transition, Un
Wnt/β‐Catenin Signaling Pathway Upregulates c‐Myc Expression to Promote Cell Proliferation of P19 Teratocarcinoma Cells

Aberrant activation of the Wnt/β‐catenin signaling pathway is a common event in human tumor progression. Wnt signaling has also been implicated in maintaining a variety of adult and embryonic stem cells by imposing a restraint to differentiation. To understand the function and mechanism of Wnt/β‐catenin signaling on the pathogenesis of teratocarcinoma, we used the mouse teratocarcinoma P19 cell line as a model in vitro. Gsk3β specific inhibitor (SB216763) was used to activate Wnt/β‐catenin signaling. All trans‐retinoic acid (RA) was used to induce P19 cell differentiation. At different culture times, gene expression was examined by immunofluorescence staining, quantitative real‐time PCR, and Western‐blotting; BrdU incorporation assays were performed to measure P19 cell proliferation. Small interference RNA technology was used to downregulate c‐myc expression. The results showed that SB216763 induced the nuclear translocation of β‐catenin, upregulated the expression of c‐myc and pluripotency related genes, oct4, sox2 and nanog, and blocked cell differentiation induced by all trans‐RA. The proliferation of P19 cells was significantly enhanced by SB216763, as well as c‐myc overexpression. C‐myc downregulation inhibited P19 cell proliferation caused by activation of Wnt/β‐catenin signaling and induced P19 cell differentiation. In conclusion, activation of the Wnt/β‐catenin pathway could promote the proliferation and inhibit the differentiation of mouse teratocarcinoma cells by upregulation of c‐myc expression. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
An innovative beacon-assisted bi-mode positioning method in wireless sensor networks

In wireless sensor networks (WSN), location information is important to ensure both performance and efficiency of WSN. This paper presents a new positioning method in WSN with reasonable implementation cost and excellent performance. Given a few beacon nodes with known locations and node range estimates based on beacon signals, all nodes' location information can be derived in a passive active mode by solving a set of circle equations through data propagation. Time synchronization is not necessary for all sensor nodes. The dilution of precision for beacon nodes is also discussed. This technique is cost-efficient, scalable and easy to implement. The simulation results show that the proposed method is fast convergent and precise.
5G beam-steering 2×2 butler matrix with slotted waveguide antenna array

In this research paper, substrate integrated waveguide (SIW) was proposed as a technique by realizing bilateral edge walls to produce a compact 5G beam-steering antenna at 24 GHz. The beam forming network is produced using SIW directional coupler perform as 2×2 Butler Matrix (BM) fed with SIW slotted waveguide antenna array. The output signal is steered from -29 degrees and +29 degrees when the signal is fed to the respective input ports. If one of the input ports is fed, the signal is evenly distributed between the adjacent output ports with 90 degree constant phase shift. The compact size of directional coupler was designed by longitude slots on the surface of SIW substrate with bandwith of 16.85% at the operating frequency. The proposed antenna produce gain of 6.34 dB at operating frequency and the promising outcome of the beam steering make proposed design suitable for 5G communications especially with tracking capabilities.
Understanding Foreign Exchange Option Returns: The Information Content of Volatility

According to general asset pricing theory, options should reward their holders for the systematic risk they are bearing. In this paper, we study the returns of foreign exchange options. We find that, by sorting options according to the distance of their implied volatility from the historical volatility, we obtain portfolios with positive average monthly returns. These returns are not explained by standard aggregate risk factors, which suggest either that additional risk factors should be accounted for, or that investors behavior differs from the traditional paradigm of rational agents.
Maturation of Mouse Primordial Follicles by Combination of Graftingand In Vitro Culture1

Abstract Cryopreservation of ovarian cortical tissue and subsequent transplantation or in vitro culture of follicles are technologies under development with the aim to safeguard fertility in patients with gonadal failure. In the present study, we investigated whether primordial follicles could be triggered to full maturation by a combination of in vivo transplantation and in vitro culture in a mouse model. In a first step, newborn mouse ovaries containing only primordial follicles were allotransplanted under the renal capsule of ovariectomized recipient mice. The second step was to mechanically isolate growing preantral follicles from the graft and culture these in vitro to maturity. In our experiment, one newborn mouse ovary was transplanted under the renal capsule of each 8- to 12-wk-old F1 (C57Bl/6j × CBA/Ca) female ovariectomized recipient (n = 26). Two weeks after transplantation, all 26 grafts were recovered. Four grafts were processed for histology and showed that developmental stages of follicles in 14-day-old ovarian grafts were comparable to those in 14-day-old mouse ovaries. The 22 remaining grafts were used for mechanical isolation of preantral follicles. As a control group, preantral follicles isolated from ovaries of 14-day-old mice were used. The mean preantral follicle yield per ovary was 11 in the transplant group versus 33 in the control group. Follicles were cultured individually in 20-μl droplets of α-MEM supplemented with 100 mIU rFSH and 5% fetal bovine serum for 12 days under an atmosphere of 5% CO2 in air at 37°C. By Day 12 of culture, 66.5% of follicles retained their oocytes in the grafting group versus 97.5% in the control group (P < 0.001). Final oocyte maturation was induced by addition of 2.5 IU/ml hCG. At 14–16 h post-HCG, the percentages of oocytes showing germinal vesicle breakdown and polar body extrusion were significantly higher in the control group (90.6% and 82.8%) compared to the grafting group (60% and 45%). The mean diameter of the mature oocytes of the grafting group (69.9 ± 4.45 μm) was similar to that of oocytes from the control group (70.5 ± 2.35 μm). Our results suggest that maturation of mouse primordial follicles is feasible by combination of in vivo transplantation and in vitro culture. This two-step strategy may be an attractive model for promoting the growth and maturation of primordial follicles from other species.
The Role of Formative Research in the National HIV Behavioral Surveillance System

The National Human Immunodeficiency Virus (HIV) Behavioral Surveillance System (NHBS) is the Centers for Disease Control and Prevention's (CDC's) newest system for measuring HIV risk behaviors among three adult populations at highest risk for HIV infection in the U.S.: men who have sex with men, injecting drug users, and heterosexuals at risk of HIV infection. The system is implemented by state and local health departments in designated metropolitan statistical areas with the highest HIV/acquired immunodeficiency syndrome (AIDS) prevalence in the U.S. Prior to implementing the behavioral surveillance survey, project sites conduct a series of formative research activities. The data collected during this preparatory phase provide contextual information about HIV risk behaviors within the study population of interest and help project sites make decisions about field operations and other logistical issues. This article describes the activities undertaken in preparation for the first round of NHBS (2003–2007) and how those activities enhanced data collection for each behavioral surveillance cycle.
The thesaurus in syntax and semantics

The recent work of the Unit has been primarily concerned with the employment of thesauri in machine translation. Limited success has been achieved, in punched-card tests, in improving the idiomatic quality and so the intelligibility of an initially unsatisfactory translation, by word-for-word procedures, from Italian into English, by using a program which permitted selection of final equivalents from "heads" in Roget's Thesaurus, i
Effect of different levels of saturated solution of calcium chloride in the preparation of calcium salt of fatty acid and its effect on rumen protozoa, pH and ammonia nitrogen

Calcium salt of fatty acid was prepared by adding 3 different levels of saturated solution of calcium chloride (CaCl 2 ) to soybean oil. It was found that fat content was not significantly affected by calcium chloride. However, calcium chloride had significant effect on other parameters like dry matter, fat, ash and sodium. The highest calcium and fat was obtained when 3.5 parts CaCl 2 were added (p<0.01). It was also observed that “sun drying” and “drying at room temperature” had no significant effect on any parameter except dry matter content. Calcium salt of fatty acid had significant anti-protozoal effect (p<0.01) in sheep. Treated group showed reduced protozoal number without affecting the rumen pH and rumen ammonia nitrogen. It was also found that the number of rumen protozoa in rumen liquor was less at 12:00 p.m. than that at 3:30 p.m. when sheep were fed 3% calcium salt. Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:. 0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} DOI: http://dx.doi. org/ 10.3329/bjas.v42i2. 18489 Bang. J. Anim. Sci. 2013. 42 (2): 109-113 Normal 0 false false false EN-US X-NONE X-NONE
Oxytocin Receptor Distribution Reflects Social Organization in Monogamous and Polygamous Voles

The neuropeptide oxytocin has been implicated in the mediation of several forms of affiliative behavior including parental care, grooming, and sex behavior. Here we demonstrate that species from the genus Microtus (voles) selected for differences in social affiliation show contrasting patterns of oxytocin receptor expression in brain. By in vitro receptor autoradiography with an iodinated oxytocin analogue, specific binding to brain oxytocin receptors was observed in both the monogamous prairie vole (Microtus ochrogaster) and the polygamous montane vole (Microtus montanus). In the prairie vole, oxytocin receptor density was highest in the prelimbic cortex, bed nucleus of the stria terminalis, nucleus accumbens, midline nuclei of the thalamus, and the lateral aspects of the amygdala. These brain areas showed little binding in the montane vole, in which oxytocin receptors were localized to the lateral septum, ventromedial nucleus of the hypothalamus, and cortical nucleus of the amygdala. Similar differences in brain oxytocin receptor distribution were observed in two additional species, the monogamous pine vole (Microtus pinetorum) and the polygamous meadow vole (Microtus pennsylvanicus). Receptor distributions for two other neurotransmitter systems implicated in the mediation of social behavior, benzodiazepines, and mu opioids did not show comparable species differences. Furthermore, in the montane vole, which shows little affiliative behavior except during the postpartum period, brain oxytocin receptor distribution changed within 24 hr of parturition, concurrent with the onset of maternal behavior. We suggest that variable expression of the oxytocin receptor in brain may be an important mechanism in evolution of species-typical differences in social bonding and affiliative behavior.