Miracle-dz/UniFAR-FTUs huggingface dataset:
microRNA and Other Small RNA Sequence Profiling across Six Tissues of Chinese Forest Musk Deer (Moschus berezovskii)

The Chinese forest musk deer (Moschus berezovskii) is an economically important species distributed throughout southwest China and northern Vietnam. Occurrence and development of disease are aggravated by inbreeding and genetic diversity declines in captive musk deer populations. Deep transcriptomics investigation may provide a promising way to improve genetic health of captive and wild FMD population. MicroRNAs (miRNAs), which regulate gene expression by targeting and suppressing of mRNAs, play an important role in physiology and organism development control. In this study, RNA-seq technology was adopted to characterize the miRNA transcriptome signature among six tissues (heart, liver, spleen, lung, kidney, and muscle) in Chinese forest musk deer at two years of age. Deep sequencing generated a total of 103,261,451 (~87.87%) good quality small RNA reads; of them 6,622,520 were unique across all six tissues. A total of 2890 miRNAs were identified, among them 1129 were found to be expressed in all tissues. Moreover, coexpression of 20 miRNAs (>2000RPM) in all six tissues and top five highly expressed miRNAs in each tissue implied the crucial and particular function of them in FMD physiological processes. Our findings of forest musk deer miRNAs supplement the database of transcriptome information for this species and conduce to our understanding of forest musk deer biology.
Oximetry, heart rate variability, and the diagnosis of mild-to-moderate acute mountain sickness

The clinical evaluation of acute mountain sickness (AMS) is often performed in remote settings with minimal equipment. The purpose of this study was to examine the utility of heart rate variability and other cardiovascular parameters in a high-altitude clinical setting. Forty-one participants were recruited from the patient population of the clinic, and from festivalgoers [those who attended the Janai Purnima festival held at Lake Gosainkunda (4380 m) in Langtang, Nepal] in the vicinity of the clinic. Twenty-one participants were diagnosed with AMS; remaining participants were free from altitude illness. Heart rate variability (both time and frequency domain measures), arterial oxygen saturation (SpO2), blood pressure and Lake Louise Score were evaluated in all the participants. Oxygen saturation and diastolic blood pressure were negatively and positively correlated with Lake Louise Score, respectively. Receiver operating characteristic analysis indicated that an SpO2 of 86% or greater was associated with a very low likelihood of AMS at this altitude. No heart rate variability parameters were different in the AMS group as compared with the control group. In conclusion, in patients with SpO2 of 86% or more at 4380 m or higher, the likelihood of AMS is low. Diastolic blood pressure correlated with AMS severity, whereas heart rate variability was not useful in the diagnosis of AMS.
Isolation of Three Contiguous Genes, ACR1, ACR2 and ACR3, Involved in Resistance to Arsenic Compounds in the Yeast Saccharomyces cerevisiae

A 4·2 kb region from Saccharomyces cerevisiae chromosome XVI was isolated as a yeast fragment conferring resistance to 7 mM‐sodium arsenite (NaAsO2), when put on a multicopy plasmid. Homology searches revealed a cluster of three new open reading frames named ACR1, ACR2 and ACR3. The hypothetical product of the ACR1 gene is similar to the transcriptional regulatory proteins, encoded by YAP1, and YAP2 genes from S. cerevisiae. Disruption of the ACR1 gene conduces to an arsenite and arsenate hypersensitivity phenotype. The ACR2 gene is indispensable for arsenate but not for arsenite resistance. The hypothetical product of the ACR3 gene shows high similarity to the hypothetical membrane protein encoded by Bacillus subtilis ORF1 of the skin element and weak similarity to the ArsB membrane protein of the Staphylococcus aureus arsenical‐resistance operon. Overexpression of the ACR3 gene confers an arsenite‐ but not an arsenate‐resistance phenotype. The presence of ACR3 together with ACR2 on a multicopy plasmid expands the resistance phenotype into arsenate. These findings suggest that all three novel genes: ACR1, ACR2 and ACR3 are involved in the arsenical‐resistance phenomenon in S. cerevisiae. © 1997 John Wiley & Sons, Ltd.
Comparison of Infectious and Noninfectious Intracranial Caseating Granulomas

Although caseating granulomas are classically associated with infectious processes, a subgroup of intracranial caseating granulomas without identifiable infectious pathology (ICGN) is described. We aimed to identify clinical, laboratory, radiological and histological markers with potential to distinguish patients with ICGN from those with intracranial caseating granulomas with infectious etiology (ICGI) on tissue microbiological examinations. In a referral hospital setting, we identified 11 patients with ICGNs and 6 patients with ICGI over an 11‐year period. The two groups had similar demographics (other than higher infection risk factors in ICGIs), clinical presentation, serology, location of lesions and cellular composition of the inflammatory infiltrate. Significant differences were the homogenous vs. ring pattern of enhancement on neuroimaging and small (<1 mm) vs. large (>1 mm) area of necrosis on histological examination, in ICGNs and ICGIs, respectively. The dichotomy was best reflected in the response of ICGNs to immunomodulatory and not antimicrobial treatment and the reverse pattern in ICGIs. Based on these findings, we suggest a scheme for the diagnosis of ICGN: (i) caseating granulomas with areas of necrosis predominantly <1 mm in diameter; (ii) absence of an identifiable infectious agent in extensive tissue examinations; and (iii) no clinical and radiological response within 2 months of appropriate antimicrobial treatment.
Edaphic Filters and Plant Colonization in a Mine Revegetated with Sewage Sludge

We evaluated the recruitment of plant species and their relation with edaphic attributes in a mine revegetated with sewage sludge in the Brazilian Federal District. Plant species in the revegetated mine and in remaining portions of Cerrado (savanna) within the mined landscape were sampled and identified. Then, samples of revegetated substrate and soils from Cerrado portions were collected, analyzed for chemical attributes and submitted to statistical tests. Results indicated that the remaining portions of Cerrado were colonized by 91 species (22% allochthonous species), and the revegetated substrate housed 62 species (55% allochthonous species). Multivariate tests showed that the edaphic condition built from the incorporation of sewage sludge into the mining substrate acted as filter on the assemblage of plant species. Despite the two study sites shared the same landscape, the Cerrado portions and the revegetated substrate did not share similar plant communities after a decade from mine rehabilitation works.
Atmospheric water vapor content from spaceborne POLDER measurements

The POLDER instrument on board ADEOS provides the first opportunity to apply the two-channel ratio technique in the near infrared to retrieve atmospheric water vapor content at the global scale. Over land, POLDER estimates compare well with radiosonde measurements, with a 3.1-kg m/sup -2/ rms error. There is a clear negative bias of a few kg m/sup -2/ however. This bias can be explained by the spectral variation of the target reflectance between the two bands used for the estimate. Over ocean, POLDER estimates compare very well with either radiosonde measurements (6.9 kg m/sup -2/ rms error) or SSM/I estimates (4.2 kg m/sup -2/ rms error). A mapped POLDER product shows a good overall similarity with ECMWF analyzed field, with smaller synoptic structures in the POLDER field. An example of the monthly product is presented.
An Ultra Low-Voltage Low-Power Capacitance-to-Digital Converter for Wirelessly Powered Intraocular Pressure Sensor

This paper presents the design and implementation of a low-power and low-voltage capacitance-to-digital converter (CDC) for a wirelessly powered intraocular pressure (IOP) sensor. To minimize power consumption and enable operation with ultra low voltages, a CDC is designed based on a <inline-formula> <tex-math notation="LaTeX">${\Delta \Sigma }$ </tex-math></inline-formula> modulation using the inverter amplifier operating in the deep-subthreshold region as integrator amplifiers. The CDC, implemented in 0.13 <inline-formula> <tex-math notation="LaTeX">${\mu }\text{m}$ </tex-math></inline-formula> CMOS process and tested in a pressure chamber with MEMS capacitive sensors, obtains an integral non-linearity of 2.1 mmHg (corresponding to 1.25 fF) over a range of 0–70 mmHg above ambient only consuming 30 nW from a 325-mV supply. This paper presents the highest reported capacitive resolution, the lowest reported power and operating voltage for CDC used with IOP measurement, obtaining a <inline-formula> <tex-math notation="LaTeX">${4.5\times }$ </tex-math></inline-formula> reduction in operating voltage and a <inline-formula> <tex-math notation="LaTeX">${3.7\times }$ </tex-math></inline-formula> reduction in power consumption over existing state-of-the-art.
Inertia identification for speed control of PMSM servo motor

In most servo motor drive applications, speed control is affected not only by disturbance torque but also by mechanical parameters such as inertia and friction coefficient. This paper presents a new technique for the inertia and friction identification which are based on adaptive identification. The strategy has been simulated and implemented in a drive system. The results demonstrate the high performance of the scheme.
Análisis de la heterogeneidad genética del adenocarcinoma ductal de páncreas y su relación con las características de la enfermedad

[ES]En la actualidad se conoce que el adenocarcinoma ductal de pancreas (ADCP) es una neoplasia histologica y geneticamente heterogenea. No obstante, la informacion disponible acerca de los patrones geneticos de evolucion clonal y de los mecanismos moleculares implicados en la enfermedad (ya sea en su desarrollo y progresion biologica o en su transformacion maligna) y su comportamiento clinico, sigue siendo limitado, especialmente en lo que se refiere a la identificacion de biomarcadores con utilidad diagnostica y de posibles dianas terapeuticas. Un numero creciente de estudios indica que el comportamiento clinico y biologico de una neoplasia depende en gran medida de las alteraciones geneticas subyacentes y de las interacciones entre las celulas tumorales y el micromedioambiente que las rodea, traducidas a su vez en distintos perfiles de alteracion genetica y de expresion genica, que para el ADCP, siguen sin conocerse en profundidad, especialmente en lo que se refiere a las distintas vias de evolucion clonal existentes a nivel intratumoral. En el presente trabajo doctoral nos hemos planteado como objetivo general profundizar en el conocimiento de las alteraciones geneticas y genomicas del ADCP, con especial enfasis en las vias de evolucion clonal presentes a nivel intratumoral, y su impacto en el comportamiento clinico y biologico de la enfermedad. Para esto hemos analizado tumores de 55 pacientes con ADCP mediante tecnicas que permiten el analisis de las alteraciones cromosomicas a nivel de celulas individuales (iFISH), en combinacion con tecnicas moleculares de analisis global del genoma y su perfil de expresion. Esta aproximacion nos ha permitido profundizar en el conocimiento de la heterogeneidad genetica y de las vias de evolucion clonal existentes, tanto a nivel intratumoral en cada paciente, como a nivel intertumoral entre distintos pacientes con ADCP. Nuestros resultados nos indican que el ADCP presenta perfiles de aberracion citogenetica y de expresion genica altamente complejos, asociados a la alteracion de multiples genes. A traves de estas caracteristicas, definimos subgrupos geneticos de tumores asociados a caracteristicas clinicas e histopatologicas de la enfermedad, como el estadio y el grado histologico de los tumores, asi como la supervivencia de los pacientes. En base a estos hallazgos construimos un sistema de estratificacion de los pacientes con ADCP que los clasifica en categorias con distinto pronostico, cuya aplicacion en la clinica podria ayudar a definir estrategias para el seguimiento y el tratamiento de los pacientes con esta enfermedad.
Understanding Deviations from Clinical Practice Guidelines in Adult Soft Tissue Sarcoma

In recent years we have witnessed the increasing adoption of clinical practice guidelines (CPGs) as decision support tools that guide medical treatment. As CPGs gain popularity, it has become evident that physicians frequently deviate from CPG recommendations, both erroneously and due to sound medical rationale. In this study we developed a methodology to computationally identify these deviation cases and understand their movitation. This was achieved using an integrated approach consisting of natural language processing, data modeling, and comparison methods to characterize deviations from CPG recommendations for 1431 adult soft tissue sarcoma patients. The results show that 48.9% of patient treatment programs deviate from CPG recommendations, with the largest deviation type being overtreatment, followed by differences in drug treatments. Interestingly, we identified over a dozen potential reasons for these deviations, with those directly related to the patients' cancer status being most abundant. These findings can be used to modify CPGs, increase adherence to CPG recommendations, reduce treatment cost, and potentially impact sarcoma care. Our approach can be applied to additional diseases that are subject to high deviation levels from CPGs.
IEEE Transactions on Nuclear Science, Vol. NS-32, No. 5, October 1985 POWER COMBINERS/DIVIDERS FOR LOOP PICKUP AND KICKER ARRAYS FOR FNAL STOCHASTIC COOLING RINGS*

The anti-proton accumulator and debuncher at FNAL will use stochastic methods to "cool" the beam. Pairs of quarter-wavelength directional-coupler loops [1] are used to detect and kick the beam. The loops are copper plates which are flush with the upper and lower wall of a rectangular beam pipe. The plates, when surrounded by a properly sized pocket, form a 100-ohm transmission-line directional coupler. As the beam passes, a signal which gives position and time information, is induced in the plates. But, because the signal levels are low (<.5 picowatts per pair), a power combiner (usually several primary combiners feeding a secondary combiner) is used to combine the outputs of many loops. Subsequently, the combined signal is amplified, filtered and then fed into a divider, (that is, a combiner operating in reverse). The divider distributes the signal into a different set of loops which modify (kick) the beam's position. Since the loop couplers are arranged linearly, in arrays of various lengths, see Fig. 1, combiners also provide a convenient method of reducing the number of vacuum feedthroughs and preamplifiers and their related costs in performance and dollars. In this note we describe various stripline combiner systems that add the outputs of 4, 8, 16 or 32 loops.
The Statistics of Spike Trains

The timecourse of every action potential (AP) in a cell measured at the soma might not be identical, due to differences in the open channel configuration. However, axons tend to contain only the Na and K channels needed for AP propagation, and therefore exhibit little or no timecourse variation. Further, there is no experimental evidence I am aware of to indicate that AP shape affects vesicle release. Thus, from the point of view of inter-neuron communication the only thing that matters about an AP or spike is its time of occurance. A spike train is the sequence of times at which a cell spikes: S = {t1, t2, . tN}. It is often useful to write this as a function in time using the Dirac-delta form,
Experiences in Becoming a Paramedic: The Professional Socialization of University Qualified Paramedics

In this article, the professional socialization of university educated paramedics from the United Kingdom and Australia is discussed using the anticipatory, formal and post-formal phases of so-cialization. Participants for this research were from universities and ambulance services in Aus-tralia and the United Kingdom, and the data were collected and analyzed by qualitative methods. The anticipatory, formal and post-formal phases were deemed to be relevant to the professional socialization of university paramedics. However a fourth phase, called the post-internship phase was identified which better accounted for the paramedic training and practice model. The findings from this research led to the development of a four phase model of professional socialization to describe the experiences of university educated paramedics making the transition from university students to qualified paramedics.
Malnutrition Predicts Clinical Outcome in Patients with Neuroendocrine Neoplasia

Malnutrition is a common problem in oncological diseases, influencing treatment outcomes, treatment complications, quality of life and survival. The potential role of malnutrition has not yet been studied systematically in neuroendocrine neoplasms (NEN), which, due to their growing prevalence and additional therapeutic options, provide an increasing clinical challenge to diagnosis and management. The aim of this cross-sectional observational study, which included a long-term follow-up, was therefore to define the prevalence of malnutrition in 203 patients with NEN using various methodological approaches, and to analyse the short- and long-term outcome of malnourished patients. A detailed subgroup analysis was also performed to define risk factors for poorer outcome. When applying malnutrition screening scores, 21-25% of the NEN patients were at risk of or demonstrated manifest malnutrition. This was confirmed by anthropometric measurements, by determination of serum surrogate parameters such as albumin as well as by bioelectrical impedance analysis (BIA), particularly phase angle α. The length of hospital stay was significantly longer in malnourished NEN patients, while long-term overall survival was highly significantly reduced. Patients with high-grade (G3) neuroendocrine carcinomas, progressive disease and undergoing chemotherapy were at particular risk of malnutrition associated with a poorer outcome. Multivariate analysis confirmed the important and highly significant role of malnutrition as an independent prognostic factor for NEN besides proliferative capacity (G3 NEC). Malnutrition is therefore an underrecognized problem in NEN patients which should systematically be diagnosed by widely available standard methods such as Nutritional Risk Screening (NRS), serum albumin assessment and BIA, and treated to improve both short- and long-term outcomes.
Determinants of Use of Household-level Water Chlorination Products in Rural Kenya, 2003–2005

Household-level water treatment products provide safe drinking water to at-risk populations, but relatively few people use them regularly; little is known about factors that influence uptake of this proven health intervention. We assessed uptake of these water treatments in Nyanza Province, Kenya, November 2003–February 2005. We interviewed users and non-user controls of a new household water treatment product regarding drinking water and socioeconomic factors. We calculated regional use-prevalence of these products based on 10 randomly selected villages in the Asembo region of Nyanza Province, Kenya. Thirty-eight percent of respondents reported ever using household-level treatment products. Initial use of a household-level product was associated with having turbid water as a source (adjusted odds ratio [AOR] = 16.6, p = 0.007), but consistent usage was more common for a less costly and more accessible product that did not address turbidity. A combination of social marketing, retail marketing, and donor subsidies may be necessary to extend the health benefits of household-level water treatment to populations most at risk.
Genetic algorithm based fast speed response induction motor drive with ANN flux estimator

This paper presents a genetic algorithm based controller for poly-phase induction motor drive. The proportional and integral gain of PI controller is optimized by genetic algorithm. An adaptive recurrent neural network (RNN) is proposed to estimate the stator and rotor fluxes. An online tuning scheme to update the weight of RNN is presented to overcome stator resistance variation problem. This tuning scheme requires current sensor to calculate the current error. Simulation tests have been performed to study the dynamic performances of the drive system for both the classical PI and the genetic algorithm based controllers
Visual Odometry with loop closing detection using Iterative Closest SURF Point

The work presented in this article is a part of a project on autonomous navigation of a mobile robot: case guide robot. It involves the study and development of a localization and 3D mapping algorithm for a mobile robot using RGB-D camera (Kinect sensor). The Kinect sensor allows the acquisition of color image with the depth of each pixel which makes the 3D construction and texture mapping easier. Two algorithms of visual odometry based Kinect using ICP-VSLAM and ICP-VSLAM-Key implemented and validated in indoor environment. This approach is based by using Kinect sensor embedded on the mobile robot B21R. The first algorithm uses all the images acquired for the location of the robot and the construction of its environment map, whereas the second, which uses the minimum number of images, which ensures a sufficient overlap between the images to avoid cumulative Error at each iteration.
Liver involvement in systemic lupus erythematosus: incidence, clinical course and outcome of lupus hepatitis.

OBJECTIVES The aims of this study were to assess the spectrum of liver disease occurring in systemic lupus erythematosus (SLE), primarily the incidence, clinical course and outcome of lupus hepatitis (LH). METHODS The records of 283 SLE out-patients referred to our Unit between 1994 and 2008 were reviewed to identify clinical or laboratory evidence of liver involvement. Liver enzyme values were considered abnormal when a sustained increase in serum transaminase levels above the normal value was observed for a period of at least three months or when the increase was confirmed in two consecutive assessments. Study inclusion criteria were a follow-up of at least 12 months and three liver function tests per year over the course of disease. RESULTS A total of 242 patients with a mean follow-up of 72.2+/-59.1 months were identified. Liver enzyme abnormalities were observed in 45 (18.6%) patients. Of these, only 14 cases (5.8%) could be attributed to LH. Clinical course and response to therapy enabled the identification of three different patterns: remitting, unremitting and relapsing forms. Acute hepatitis and liver failure were not observed. Low serum alanine transaminase levels at diagnosis and high doses of prednisone were associated to resolution of LH. Clinical course or response to therapy did not appear to be affected by liver histology or serological findings. CONCLUSIONS LH is generally sub-clinical with a fluctuating course and responds well to moderate to high doses of prednisone without progression to end-stage liver disease.