Miracle-dz/UniFAR-FTUs huggingface dataset:
A Frame Work for Extraction , Integration and Analysis of Unified Medical Language System

A Unified Medical Language System (UML) is a huge repository of biomedical literature. It helps us to compute the analysis of diverse data collections and to predict links between genes and diseases. We mainly focus on the analysis of biomedical literature for the identification of genes encoding DNA binding transcription factors in neurological diseases. We also use the biomedical literature and organized ontologies and vocabularies for both gene and diseases . To connect these data sources, we use both manually and automatically annotated linkages, such as the reviewed user-submitted Gene Reference into Function (GeneRIF) annotations in Entrez Gene and the computationally generated Related Articles from Pub Med.
Underdiagnosis of depression in an economically deprived population in Macao, China

Previous literature revealed an association between low income and depression. Despite the availability of effective treatments, depression is often underdiagnosed and undertreated. This study was designed to evaluate the prevalence of depressive symptoms and their impact on health‐related quality of life (HRQoL) in a low‐income population in Macao.
Mechanical analysis of pimple growth and pain level characterization

Pimple is one of the most common skin diseases for humans. The mechanical modeling of pimple growth is very limited. A finite element model is developed to quantify the deformation field with the expansion of follicle, and then the mechanical stimulus is related to the sensation of pain during the development of pimple. Through these models, parametric studies show the dependence of mechanical stimulus and pain level on the pimple-surrounded structures, follicle depth and mechanical properties of the epidermis. The findings in this paper may provide useful insights on prevention or pain relief of pimples, as well as those related to cosmetics and other tissue growth.
Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor

Endocytosis and recycling of membrane proteins are key processes for nutrient uptake, receptor signaling and synaptic transmission. Different steps in these fission and fusion cycles have been proposed to be regulated by physiological changes in plasma membrane (PM) phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2] concentration. Here, we use a chemical enzyme-translocation strategy to rapidly reduce PM PtdIns(4,5)P2 levels while monitoring clathrin-mediated endocytosis and recycling. PtdIns(4,5)P2 hydrolysis blocked transferrin receptor endocytosis and led to a marked increase in the concentration of transferrin receptors in the PM, suggesting that endocytosis is more sensitive to changes in PtdIns(4,5)P2 than recycling. Reduction of PM PtdIns(4,5)P2 levels led to a near complete dissociation of Adaptor protein 2 (AP-2) from the PM but had only a small effect on clathrin assembly. This argues that receptor-mediated PtdIns(4,5)P2 reduction preferentially suppresses AP-2-mediated targeting of cargo to endocytic sites rather than the assembly of clathrin coats or recycling of endocytic vesicles.
Mathematical and Experimental Investigations of Modeling, Simulation and Experiment to Promote the Life-Cycle of Polymer Modified Asphalt

The formulation of constitutive equations for asphaltic pavement is based on rheological models which include the asphalt mixture, additives, and the bitumen. In terms of the asphalt, the rheology addresses the flow and permanent deformation in time, under different temperatures, and under different loading conditions. Currently, there are various laboratory methods used to determine the rheological parameters of the asphalt. Unfortunately, most of these tests are conducted in the linear viscoelastic region, therefore the true picture of asphalt during in-service has not been fully investigated. Furthermore there are quite few polymer-modified asphalts that have been used. The mathematical models needed to formulate and model these materials are limited. This study attempts to develop a mathematical approach to the modeling of polymer modified asphalt which is applicable in pavement design.
Urinary metals in a spontaneous canine model of calcium oxalate urolithiasis

Calcium oxalate urolithiasis is a common and painful condition in people. The pathogenesis of this disease is complex and poorly understood. Laboratory animal and in vitro studies have demonstrated an effect of multiple trace metals in the crystallization process, and studies in humans have reported relationships between urinary metal concentrations and stone risk. Dogs are a spontaneous model of calcium oxalate urolithiasis, and the metal content of canine calcium oxalate stones mirrors that of human stones. The aim of this study was to test for a relationship between urinary metals and calcium oxalate urolithiasis in dogs. We hypothesized that urinary metals would differ between dogs with and without calcium oxalate urolithiasis. Urine from 122 dogs (71 cases and 51 stone-free controls) was analyzed for calcium and 12 other metals. The cases had higher urinary calcium, copper, iron, and vanadium and lower urinary cobalt. Higher urinary vanadium in the cases was associated with being fed a therapeutic stone-prevention diet. Urinary calcium had a strong positive correlation with strontium and moderate positive correlations with chromium, nickel, and zinc. The results of this study complement the findings of similar human studies and suggest a potential role of trace metals in calcium oxalate urolithiasis. Further investigation into how trace metals may affect stone formation is warranted.
On the lifting problems and their connections with piecewise affine control law design

Lifting as geometric operation can be defined as a pseudo-inverse of orthogonal projection. It has received attention in different fields and applications (mechanics, geometry, control, etc). Numerous studies have been dedicated to the existence conditions of a convex lifting in a higher dimension for a given cell complex. It is worth noting that this notion can be extended for a polyhedral partition for applications in control theory, and it is recently shown to be the key step in solving the inverse parametric linear/quadratic programming problems. The present paper presents in a succinct manner the main elements of this topological problem with specific attention to the case of polyhedral partitions and their liftings. Furthermore, we are interested from the practical point of view, in the use of these concepts in control system design. Practically, a construction for the Voronoi diagram class is presented. Secondly, a methodological result is presented which leads to the modification of partitions guaranteeing a theoretically liftable result. In addition, a generic constructive procedure for the partitions based on convexity, continuity and linear (or quadratic) programming is proposed. In order to bring the discussion closer to the control related formulations, the correspondence between convex liftings of a given partition in ℝd onto (d+1)-space and n-space with n > d+1 is provided. Finally an analysis with respect to predictive control related problems will conclude our contribution.
Supporting knowledge collaboration using social networks in a large-scale online community of software development projects

The scale-free network shown in the small world phenomenon indicates that our human society consists of a small number of people who play the role of hubs linked with many nodes (persons) and a large number of people as nodes linked with few nodes. From our analysis of a large-scale online community - SourceForge.net - which has a large number of developers and projects, we have found that SourceForge also exists as a scale-free network. That is, only a minority of developers joins many projects and has rich links with other developers, while the majority joins few projects and has very limited social relations with others. The goal of our study is to build a system that supports knowledge collaboration in a large-scale online community of software development projects. In this paper, we discuss the challenges of supporting knowledge collaboration in such a large online community that is a scale-free network and then introduce the prototype system called D-SNS (dynamic social networking system).
Nuglets: a Virtual Currency to Stimulate Cooperation in Self-Organized Mobile Ad Hoc Networks

In mobile ad hoc networks, it is usually assumed that all the nodes belong to the same authority; therefore, they are expected to cooperate in order to support the basic functions of the network such as routing. In this paper, we consider the case in which each node is its own authority and tries to maximize the benefits it gets from the network. In order to stimulate cooperation, we introduce a virtual currency and detail the way it can be protected against theft and forgery. We show that this mechanism fulfills our expectations without significantly decreasing the performance of the network.
Design, synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2

Abstract In this article, the derivatives of 3-quinoline carboxylic acid were studied as inhibitors of protein kinase CK2. Forty-three new compounds were synthesized. Among them 22 compounds inhibiting CK2 with IC50 in the range from 0.65 to 18.2 μM were identified. The most active inhibitors were found among tetrazolo-quinoline-4-carboxylic acid and 2-aminoquinoline-3-carboxylic acid derivatives.
Elasticity and Strength of Nano-Fiber Reinforced Composites from First Principles

Calculations of elastic moduli and theoretical tensile strength of unidirectionalcomposite having continuous nano-fiber reinforcements are performed using abinitio method. Results for tungsten nano-fibers in vanadium matrix are presentedas a particular example of the analysis. The dependence of the computedcomposite elastic moduli on the atomic concentration of W (nearly correspondingto the volume fraction of fibers) is compared with the rule of mixture for an idealcomposite. Results show that validity of the linear mixture rule is theoreticallyjustified for most of them. On the other hand, computed values of theoreticalstrength exhibit a higher monotonous increase only up to about 60% of W andpredict a synergy effect. The related analysis based on a creation of internalstresses at the fibre/matrix interface reveals that, in this way, the synergy effectcan be explained only partially.
Justification of Violence Beliefs and Social Problem-Solving as Mediators between Maltreatment and Behavior Problems in Adolescents

This study examined whether justification of violence beliefs and social problem solving mediated between maltreatment experiences and aggressive and delinquent behavior in adolescents. Data were collected on 191 maltreated and 546 nonmaltreated adolescents (ages 14 to 17 years), who completed measures of justification of violence beliefs, social problem-solving dimensions (problem orientation, and impulsivity/carelessness style), and psychological problems. Findings indicated that maltreated adolescents' higher levels of delinquent and aggressive behavior were partially accounted for by justification of violence beliefs, and that their higher levels of depressive symptoms were partially mediated by a more negative orientation to social problem-solving. Comparisons between boys and girls indicated that the model linking maltreatment, cognitive variables, and psychological problems was invariant. Este estudio examinó si las creencias justificadoras de la violencia y la resolución de problemas sociales mediaban entre las experiencias de maltrato y la conducta agresiva y delincuente en adolescentes. Se obtuvieron datos de 191 adolescentes que habían experimentado maltrato y 546 adolescentes no maltratados (edades entre 14 y 17 años). Completaron medidas de creencias justificadoras de la violencia, dimensiones de solución de problemas (orientación al problema, y estilo impulsivo) y problemas psicológicos. Los resultados indicaron que los mayores niveles de conducta agresiva y delincuente entre los adolescentes maltratados estaban parcialmente explicados por las creencias justificadoras de la violencia, y que sus mayores niveles de síntomas depresivos estaban mediados parcialmente por una orientación más negativa a los problemas sociales. Las comparaciones entre chicos y chicas indicaron que el modelo de asociación entre maltrato, variables cognitivas y síntomas psicológicos era invariante.
Dynamic balance optimization in biped robots: Physical modeling, implementation and tests using an innovative formula

SUMMARY In this paper, an analytical formula for the determination of the center of mass position in humanoid platforms is proposed and tested in a real humanoid robot. The formula uses the force-torque values obtained by the two force-torque sensors applied on the feet of the robot and the measured currents required from the motors to maintain balance as inputs. The proposed formula outputs the real center of mass position that minimizes the errors between real humanoid robots and virtual models. Data related to the Zero Moment Point positions and to the joint movements are compared with the target values, showing how the application of the proposed formula enables achieving better repeatability and predictability of the static and dynamic robot behaviour.
Crystal Structure of Porcine Reproductive and Respiratory Syndrome Virus Leader Protease Nsp1α

ABSTRACT Porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV), a positive-strand RNA virus that belongs to the Arteriviridae family of Nidovirales, has been identified as the causative agent of PRRS. Nsp1α is the amino (N)-terminal protein in a polyprotein encoded by the PRRSV genome and is reported to be crucial for subgenomic mRNA synthesis, presumably by serving as a transcription factor. Before functioning in transcription, nsp1α proteolytically releases itself from nsp1β. However, the structural basis for the self-releasing and biological functions of nsp1α remains elusive. Here we report the crystal structure of nsp1α of PRRSV (strain XH-GD) in its naturally self-processed form. Nsp1α contains a ZF domain (which may be required for its biological function), a papain-like cysteine protease (PCP) domain with a zinc ion unexpectedly bound at the active site (which is essential for proteolytic self-release of nsp1α), and a carboxyl-terminal extension (which occupies the substrate binding site of the PCP domain). Furthermore, we determined the exact location of the nsp1α self-processing site at Cys-Ala-Met180↓Ala-Asp-Val by use of crystallographic data and N-terminal amino acid sequencing. The crystal structure also suggested an in cis self-processing mechanism for nsp1α. Furthermore, nsp1α appears to have a dimeric architecture both in solution and as a crystal, with a hydrophilic groove on the molecular surface that may be related to nsp1α's biological function. Compared with existing structure and function data, our results suggest that PRRSV nsp1α functions differently from other reported viral leader proteases, such as that of foot-and-mouth disease.
Statistical Machine Translation Improvement based on Phrase Selection

This paper describes the importance of introducing a phrase-based language model in the process of machine translation. In fact, nowadays SMT are based on phrases for translation but their language models are based on classical ngrams. In this paper we introduce a phrase-based language model (PBLM) in the decoding process to try to match the phrases of a translation table with those predicted by a language model. Furthermore, we propose a new way to retrieve phrases and their corresponding translation by using the principle of conditional mutual information. The SMT developed will be compared to the baseline one in terms of BLEU, TER and METEOR. The experimental results show that the introduction of PBLM in the translation decoding improve the results.
Sentiment Classification Considering Negation and Contrast Transition

Negation and contrast transition are two kinds of linguistic phenomena which are popularly used to reverse the sentiment polarity of some words and sentences. In this paper, we propose an approach to incorporate their classification information into our sentiment classification system: First, we classify sentences into sentiment reversed and non-reversed parts. Then, represent them as two different bags-of-words. Third, present three general strategies to do classification with two-bag-of-words modeling. We collect a large-scale product reviews involving five domains and conduct our experiments on them. The experimental results show that incorporating both negation and contrast transition information is effective and performs robustly better than traditional machine learning approach (based on one-bag-of-words modeling) across five different domains.
[2-(Dimethylamino)ethanol-κ2 N,O][2-(dimethylamino)ethanolato-κ2 N,O]iodidocopper(II)

The title compound, [Cu(C4H10NO)I(C4H11NO)], was obtained unintentionally as the product of an attempted synthesis of a Cu/Zn mixed-metal complex using zerovalent copper, zinc(II) oxide and ammonium iodide in pure 2-(dimethylamino)ethanol, in air. The molecular complex has no crystallographically imposed symmetry. The coordination geometry around the metal atom is distorted square-pyramidal. The equatorial coordination around copper involves donor atoms of the bidentate chelating 2-(dimethylamino)ethanol ligand and the 2-(dimethylamino)ethanolate group, which are mutually trans to each other, with four approximately equal short Cu—O/N bond distances. The axial Cu—I bond is substantially elongated. Intermolecular hydrogen-bonding interactions involving the –OH group of the neutral 2-(dimethylamino)ethanol ligand to the O atom of the monodeprotonated 2-(dimethylamino)ethanolate group of the molecule related by the n-glide plane, as indicated by the O⋯O distance of 2.482 (12) Å, form chains of molecules propagating along [101].
Imaging of intramembranous particles in frozen‐hydrated cells (Saccharomyces cerevisiae) by high resolution cryo SEM

In order to investigate the potential of high-resolution cryoscanning electron microscopy (SEM), frozen-hydrated bulk specimens were compared with transmission electron microscopy (TEM) freeze-fracture replicas. For this purpose a field emission SEM was equipped with a cryo unit consisting of a cold stage in the electron microscopical column and a dedicated cryo preparation chamber. Baker's yeast, Saccharomyces cerevisiae, was the chosen test specimen. The hexagonally arranged intramembranous particles of the plasmic fracture face of the plasmalemma are well known from TEM freeze-fracture studies and can be clearly discerned from structures deriving from preparation artifacts. After freezing, fracturing, sputter-coating with 3 nm of platinum, and vacuum transfer to the cold goniometer stage, the 16.5 nm periodic structure was resolved in the cryo-SEM. Also, intramembranous particles in the nuclear envelope are preserved. Typical artifacts of cryo-SEM are water vapour contaminations and mass loss due to electron irradiation of ice. However, these artifacts are easily recognized and discerned from biological information. Specific advantages of cryo-SEM of frozen-hydrated specimens are: (1) In comparison to SEM of dried material, dehydration artifacts such as shrinkage can be excluded. (2) Compared with freeze-fracture replicas, larger specimens are obtained because no replica cleaning is necessary.
Characterization of henequen fibers and the henequen fiber/poly(hydroxybutyrate-co-hydroxyvalerate) interface

The henequen fiber/poly(hydroxybutyrate-co-hydroxyvalerate) resin (PHBV) interfacial shear strength was characterized by single-fiber fragmentation (SFF) (also called the single-fiber composite test) and microbond techniques. The surface microstructure and tensile properties of henequen fibers were characterized using a scanning electron microscope (SEM) and an Instron tensile testing machine. The moisture content of the fibers was measured using a Brabender rapid moisture/volatile tester. SEM photomicrographs of the longitudinal views of the henequen fibers showed their fibrillar structure and the transverse views showed their hollow/multicellular nature and noncircular cross-section. The henequen fiber/PHBV interfacial shear strength was 6.97 MPa, as measured using the SFF test, and 5.24 MPa, as measured using the microbond test. These results are surprisingly close in spite of the different stresses experienced during the SFF and microbond tests. SEM photomicrographs showed interfacial failure. The interfacial shear strength was attributed mainly to the mechanical interlocking resulting from the fiber surface roughness, since no hydrogenbonding possibility existed for PHBV.The fiber/resin mechanical interlocking, however, may also be limited because of the high viscosity of the resin, which limits its ability to penetrate into and around the cells.
Short fibers as reinforcement of rubber compounds

The effect of aramid, glass and cellulose short fibers on the processing behavior, crosslinking density and mechanical properties of natural rubber (NR), ethylenepropylene-diene terpolymer rubber (EPDM) and styrene-butadiene rubber (SBR) has been investigated. Two fiber percentages (10 and 20 phr) were added to the rubber. The results have shown that the above-mentioned fibers, especially aramid fibers, are effective reinforcing agents for these rubbers, giving rise to a significant increase in mechanical properties, such as tensile modulus and strength, and tear and abrasion resistance. Moreover, a significant decrease in the time to reach 97% of curing, t' c (97) is observed, which indicates that the fibers tend to increase the vulcanization rate, regardless of the rubber used. Fibers give also rise to an increase in crosslinking, especially the aramid fibers.
Structure and Properties of Cotton Fibers from Controlled Growth Environments

The influences of growth environment on gross and fine structures, mechanical properties, and responses to chemical treatments were determined from cotton fibers of Rex and Texas Marker-1 varieties grown under ranges of controlled environment. Cell walls of fibers composed of cellulose deposited at constant and varying temperatures were found to differ in many of their properties. The cell wall thickens more slowly at lower than at higher temperatures and the walls are thinner even though the wall development periods are longer. Properties of fibers indicate that cellulose from the low-temperature environment is less compact and more responsive to chemical reagents than from the high temperatures. The fibers from low temperatures are weaker and more extensible. Relationships between cell wall thickness, fine structure, mechanical properties and chemical reactivities are illustrated.
NB3SN AND NbTi MULTIFILAMENTARY WIRES WITH ENHANCED HEAT CAPACITY

ITER type multifilamentary superconducting wires (0.82 mm Nb3Sn wire and 0.73 mm NbTi wire) with high heat capacity at LHe temperatures have been manufactured and tested. To increase the heat capacity the corresponding billets were doped with several volume fractions of PrB6 (for Nb3Sn) and Gd2O2S (for NbTi). The volumetric heat capacity of these substances at LHe temperatures is about two orders of magnitude larger than that for the other components of the wires. Fine powders of PrB6 and Gd2O2S were incorporated into the billets by the Powder‐in‐Tube (PIT) method. For comparison the wires without dopants were produced from the same billets using identical heat treatment for each pair of wires. First comparative tests of the wires have demonstrated a noticeable increase of critical energies in a wide range of transport currents. The ways of further increase of critical energies are considered.