Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluación de estrategias de aprendizaje con HCI KINECT en alumnos con Síndrome Down

El Sindrome de Down provoca en la persona una reduccion en sus capacidades cognitivas, siendo la viso-motora una de las mas sensibles, y desde la cual se han logrado mejores aprendizajes. La investigacion general de este informe se centra en esta habilidad, y desde ella se ha conseguido estimular un mejor aprendizaje. La propuesta se basa en la estimulacion viso-espacial de ninos con SO a traves de recursos didacticos con soporte en la plataforma de interaccion gestual Tango:H. Para esto se ha planteado como pregunta de investigacion ? el desarrollo psico-cognitivo con estimulos a traves estrategias didacticas ludicas con interaccion gestual en ninos con Sindrome Down es mayor al logrado con recursos didacticos convencionales? y para su respuesta se han planteado tres estudios independientes en cuanto a forma y metodo pero relacionado de forma continua en los objetivos y poblacion de estudio. Refieren a: a) estimulacion de ! a memoria de trabajo, validando el recuerdo de los objetos de aprendizaje b) estimulacion de habilidades lectoras y su aprendizaje, validando los errores de conocimiento especifico y los tiempos de respuesta; c) aptitudes cognitivas viso-motoras, validando la capacidad de memoria viso-motriz desde el test ITPA. En los tres casos los resultados han sido favorables a los estimulos desde la plataforma de interaccion gestual Tango:H y con recursos didacticos personalizados. Ademas, se ha establecido las relaciones existentes entre el estudio realizado y los resultados previos obtenidos por la comunidad cientifica internacional. En cada estudio tambien se comenta las limitaciones del estudio, asi como las posibles lineas futuras de trabajo que surgen de toda esta investigacion.
SAP HANA Vora: A Distributed Computing Platform for Enterprise Data Lakes

Businesses are increasingly leveraging the power of Big Data to improve their services and products. We call the infrastructure to process and manage the heterogenous kinds of data their “data lakes”. Data lakes are used to store and process massive streams of sensor data, service data, collected or generated media, archived enterprise data, and massive transactional databases, among others. Such infrastructures are often realized by Hadoop clusters and low-cost persistence layers, such as S3 or SWIFT data stores. SAP HANA Vora is a distributed computing platform that sits on top of Data Lakes and was developed to build a basis layer for upcoming Big Data applications in the enterprise. It provides high-performance in-memory data processing and management capabilities, is easily extensible by new computing engines, extends the existing Big Data software stack, and integrates with the existing enterprise IT by design. We present an architectural overview of the system. 1 SAP SE, 69190 Walldorf, c.sengstock@sap.com 2 SAP SE, 69190 Walldorf, christian.mathis@sap.com
An HIV Testing Conundrum: Balancing the Health and Privacy Considerations of Multiple Stakeholders

&NA; Legal standards for HIV testing are evolving in an attempt to achieve an ethical equilibrium between the privacy rights of infected or potentially infected individuals and public health considerations that seek to limit the spread and severity of the disease through early recognition and treatment. Although guided by US Centers for Disease Control and Prevention recommendations, these standards are determined by state law. In this case, an ethical dilemma is presented and discussed in which the privacy interests of an HIV‐infected individual come into conflict with the health considerations of an inadvertently exposed neurology resident and her unborn child, a conundrum amplified by the restricted HIV testing laws of the state in which the incident took place.
Analyzing the Cryptome: Uncovering Secret Sequences

The mammalian cryptome consists of bioactive peptides generated by the proteolysis of precursor proteins. It is speculated that the cryptide repertoire increases the complexity of the proteome by an order of magnitude. Cryptides have been found to function in a wide range of processes including neuronal signaling, antigen presentation, and the inflammatory response. Due to their potential as therapeutic agents, there has been an increasing interest in studying cryptides. In this review, we discuss different approaches for discovering these hidden peptides and how proteomic tools can be utilized to aid in their identification and characterization.
Optimizing Locality-Aware Memory Management of Key-Value Caches

The in-memory cache system is a performance-critical layer in today’s web server architectures. Memcached is one of the most effective, representative, and prevalent among such systems. An important problem is on its memory allocation. The default design does not make the best use of the memory. It is unable to adapt when the demand changes, a problem known as slab calcification. This paper introduces locality-aware memory allocation (LAMA), which addresses the problem by first analyzing the locality of Memcached’s requests and then reassigning slabs to minimize the miss ratio or the average response time. By evaluating LAMA using various industry and academic workloads, the paper shows that LAMA outperforms existing techniques in the steady-state performance, the speed of convergence, and the ability to adapt to request pattern changes, and overcome slab calcification. The new solution is close to optimal, achieving over 98 percent of the theoretical potential. Furthermore, LAMA can also be adopted in resource partitioning to guarantee quality-of-service (QoS).
Lebensverdienste nach Qualifikation: Bildung lohnt sich ein Leben lang

 Die durchschnittlichen Bildungsprämien sind für alle untersuchten Personengruppen deutlich positiv. Dies gilt unabhängig von Geschlecht und Region. Insgesamt sind die Bildungsprämien für Männer und Westdeutsche stärker ausgeprägt. Bildung zahlt sich aus. Berechnungen des IAB zeigen, dass Hochschulabsolventen durchschnittlich bis zum 2,7-Fachen dessen verdienen, was Personen ohne beruflichen Abschluss erhalten. Aber auch eine Berufsausbildung ist ihr Geld wert. Über das ganze Erwerbsleben hinweg addieren sich die Bildungsprämien zu beachtlichen Summen – für alle Berufsabschlüsse, für Männer wie Frauen und in Ost wie West. Allerdings unterscheiden sich die Bildungsprämien zwischen den betrachteten Gruppen durchaus erheblich.
Chapter 8 Practical Exercise Algorithmic Composition of Contrapuntal Music

For this project, your goal is to implement a program that writes music in contrapuntal style, since this form is so fundamentally algorithmic. Contrapuntal music, also called counterpoint, is a structure of musical composition that originated in the Renaissance and was developed extensively in Baroque and Classical music, particularly in canons and fugues written by Bach and Mozart. Many species of counterpoint exist, but we will focus here on the fundamental rules common to all of them [1] [2].
Multiphase wall-bounded turbulence

In many geophysical situations and in all industrial applications, turbulent flows are wall-bounded. Many of these flows are multi-phase, i.e. flows consisting of one or multiple inclusions. The current understanding of these flows is still limited and this makes it important to study them. In this thesis we study these wall-bounded multi-phase flows in two canonical systems: Taylor-Couette flow (TC) and Rayleigh-Benard convection (RBC). In this work we used spherical and cylindrical particles to investigate if we have reduced skin friction similar to bubbly drag reduction. The global torque measurements showed that these particles barely alter the drag, even at very large particle volume fractions. Surprisingly, we found a preferential alignment for the cylindrical particles with respect to the inner cylinder wall. Using oil and water we are able to create deformable inclusions. Increasing the oil volume fraction over a critical point results in phase inversion with water droplets in oil. In this regime we found drag reduction due to the large water droplets in the flow. This is confirmed with in-situ microscopic imaging. In the last two chapters of this thesis we study the effect of non-homogeneous boundaries in both TC and RBC. Using bands of sandgrain roughness we were able to control the secondary flows in TC. This means that for example roughness like barnacles on the hull of a ship can induce secondary flows that push air bubbles away and thereby, reducing the drag reducing effect.
Techniques of new application for acquisition foreign languages: development stages and modern trend

In the conditions of scientific and technical progress and more developing international contacts in the field of science, technology, and culture, the practical knowledge of a foreign language becomes one of the most important characteristics of a highly qualified specialist of any profile. One of the important factors in the development of the system to accelerating learning is the demands of adults themselves. Therefore, we need to create an automated system fast and effective teaching another language that uses the mini-max criterion, which provides the maximum possible result to the minimum required amount of effort on the part of the student. The essence of the approach is to replace the description in our native language with visual objects using the latest technology for implementing this approach. This means that an intermediate language is introduced, not tied to any of the known languages. The Purpose of the research is to develop a methodology (technique) for applying the Visual Approach in the educational environment created on the basis of a distributed management system to accelerate the acquisition of foreign language skills by adults. The system provides the process of controlling the formation of speech skills to a threshold level, allowing the transition from language learning to its improvement and acceleration. On the basis of this new generation using continuous evaluation of the competency level of the trainee, visual models, and information technology, got them a new incarnation, opens a new direction in construction a new version of Learning Management System - E-AMS.
VMTP as the transport layer for high-performance distributed systems

The authors identify and discuss three major categories of deficiencies in current transport protocols: performance, naming, and functionality. They describe the design of the Versatile Message Transaction Protocol (VMTP) and some performance measurements of the protocol used in the V-Distributed System. They show that VMTP addresses all of the above issues within a single protocol without significant compromise. <<ETX>>
Sketch-based face alignment for thermal face recognition

In this paper, we present a novel face alignment approach in thermal infrared face recognition. The alignment procedure is based on closest point set matching between sketch faces. Linear combination of positional and local pattern features is embedded in the pointwise distance to solve the local minimum problem for ICP due to edge noise in sketch faces. The comprehensive experiments, including intra-class, inter-class and variable expressions, show the alignment accuracy and face recognition performance results of our algorithm compared to manual labelling, ICP and congealing methods.
Strengthening the understanding of the relationship between survival designs and test statistics

In the planning of randomized survival trials, the role of follow‐up time of trial participants introduces a level of complexity not encountered in non‐survival trials. Of the two commonly used survival designs, one design fixes the follow‐up time whereas the other allows it to vary. When the follow‐up time is fixed the number of events varies. Conversely, when the number of events is fixed, the follow‐up time varies. These two designs influence test statistics in ways that have not been fully explored resulting in a misunderstanding of the design–test statistic relationship. We use examples from the literature to strengthen the understanding of this relationship. Group sequential trials are briefly discussed. When the number of events is fixed, we demonstrate why a two‐sample risk difference test statistic reduces to a one‐sample test statistic which is nearly equal to the risk ratio test statistic. Some aspects of fixed event designs that need further consideration are also discussed. Copyright © 2009 John Wiley & Sons, Ltd.
A Bayesian Design and Analysis for Dose-Response Using Informative Prior Information

We wish to use prior information on an existing drug in the design and analysis of a dose-response study for a new drug candidate within the same pharmacological class. Using the Bayesian methodology, this prior information can be used quantitatively and the randomization can be weighted in favor of the new compound, where there is less information. An E max model is used to describe the dose-response of the existing drug. The estimates from this model are used to provide informative prior information used for the design and analysis of the new study to establish the relative potency between the new compound and the existing drug therapy. The assumption is made that the data from previous trials and the new study are exchangeable. The impact of departures from this assumption can be quantified through simulations and by assessing the operating characteristics of various scenarios. Simulations show that relatively modest sample sizes can yield informative results about the magnitude of the relative potency using this approach. The operating characteristics are good when assessing model estimates against clinically important changes in relative potency.
Sports Participation and Positive Correlates in African American, Latino, and White Girls

The purpose of the study was to examine relations among sports participation and positive correlates across African American, Latino, and White girls. Positive correlate variables were self-perceptions (self-worth, body attractiveness, athletic competence), less depression, and participation in extracurricular activities. The sample comprised 372 girls (mean age = 12.03 years). Data were analyzed using multiple-sample structural equation models, controlling for age and income. Across all ethnic groups, greater sports participation was significantly related to higher self-worth, body attractiveness, and athletic competence, and to more extracurricular activity. Among Latino and White girls only, greater sports participation also was related to less depression. There were significant age and income influences on the positive correlates. Findings confirm the existence of significant relationships between organized sports participation and positive correlates among early adolescent African American, Latino, and White girls. Despite a few ethnic differences in relationships, the current study revealed more similarities than differences.
Lineal energy-based evaluation of oxidative DNA damage induced by proton beams and X-rays

Abstract Purpose: To determine the oxidative capabilities of proton beams compared to X-rays based on lineal energy (y). Materials and methods: Microdosimetry was used to determine y-values of 155 MeV protons. Salmon testes deoxyribonucleic acid (ST-DNA) in solution and human tumor cells (MOLT-4) were irradiated with 200 kV X-rays (X) or 155 MeV protons at their plateau (P) and near their Bragg-peak (B). 8-Hydroxydeoxyguanosine (8-OHdG) production was determined by high performance liquid chromatography. Double-strand breaks (DSB) in ST-DNA were evaluated by agarose gel electrophoresis and DSB in cell nuclei were evaluated by immunocytochemical analysis of phosphorylated histone H2AX (γH2AX) foci. Edaravone was used as a radical scavenger. Results: 8-OHdG yields in ST-DNA were significantly higher with X than with P or B, and they were significantly higher with P than with B. DSB yields in ST-DNA were higher with P than with B or X, although not statistically significant, and were nearly equal with B and X. Although γH2AX foci formation in MOLT-4 cells after each irradiation type was nearly identical, the addition of edaravone significantly inhibited foci formation only with X. Conclusions: Our results indicated that radical-induced indirect DNA damage was significantly lower with proton beams than with X-rays.
Paediatric sickle cell disease: pulmonary hypertension but normal vascular resistance

Background Adults with sickle cell disease (SCD) and pulmonary hypertension have high mortality but death in SCD children with pulmonary hypertension is rare. The authors hypothesised that pulmonary hypertension in SCD children may be secondary to anaemia-induced high cardiac output rather than pulmonary vascular disease. Methods Two independent, validated techniques were used to estimate pulmonary vascular resistance (PVR) in 50 SCD children and 50 matched controls. Tricuspid regurgitant jet velocity (TRV) and right ventricular outflow tract velocity time integral were measured using Doppler echocardiography; PVR was calculated from their ratio. Acetylene rebreathing technique using respiratory mass spectrometry was also performed to calculate pulmonary blood flow and stroke index, an estimate of PVR. Results TRV was higher in SCD children compared with controls (2.28 vs 2.14 m/s, p=0.02). Fifteen of 34 (44%) children with haemoglobin of the SS genotype (HbSS) versus 1/16 (6%) children with haemoglobin of the SC genotype (HbSC) had pulmonary hypertension (TRV≥2.5 m/s) (p=0.009). Right ventricular stroke volume was higher (p<0.05) and Doppler PVR lower (1.20 (0.19) vs 1.31 (0.20) Wood units, p=0.04) in SCD children with pulmonary hypertension compared with controls. Qpeff and stroke index were higher in SCD children compared with controls (p<0.001 for both) and correlated with anaemia (p<0.001) and TRV (p=0.03). There was no correlation between TRV and history of asthma or acute chest syndrome. Conclusions Pulmonary hypertension due to raised cardiac output is common in HbSS SCD children and is associated with normal PVR. PVR should be measured before therapy with agents such as sildenafil or bosentan is contemplated.
Post‐clearcut dynamics of carbon, water and energy exchanges in a midlatitude temperate, deciduous broadleaf forest environment

Clearcutting and other forest disturbances perturb carbon, water, and energy balances in significant ways, with corresponding influences on Earth's climate system through biogeochemical and biogeophysical effects. Observations are needed to quantify the precise changes in these balances as they vary across diverse disturbances of different types, severities, and in various climate and ecosystem type settings. This study combines eddy covariance and micrometeorological measurements of surface‐atmosphere exchanges with vegetation inventories and chamber‐based estimates of soil respiration to quantify how carbon, water, and energy fluxes changed during the first 3 years following forest clearing in a temperate forest environment of the northeastern US. We observed rapid recovery with sustained increases in gross ecosystem productivity (GEP) over the first three growing seasons post‐clearing, coincident with large and relatively stable net emission of CO2 because of overwhelmingly large ecosystem respiration. The rise in GEP was attributed to vegetation changes not environmental conditions (e.g., weather), but attribution to the expansion of leaf area vs. changes in vegetation composition remains unclear. Soil respiration was estimated to contribute 44% of total ecosystem respiration during summer months and coarse woody debris accounted for another 18%. Evapotranspiration also recovered rapidly and continued to rise across years with a corresponding decrease in sensible heat flux. Gross short‐wave and long‐wave radiative fluxes were stable across years except for strong wintertime dependence on snow covered conditions and corresponding variation in albedo. Overall, these findings underscore the highly dynamic nature of carbon and water exchanges and vegetation composition during the regrowth following a severe forest disturbance, and sheds light on both the magnitude of such changes and the underlying mechanisms with a unique example from a temperate, deciduous broadleaf forest.
Clinical prediction rules. A review and suggested modifications of methodological standards.

BACKGROUND Clinical prediction rules are decision-making tools for clinicians, containing variables from the history, physical examination, or simple diagnostic tests. OBJECTIVE To review the quality of recently published clinical prediction rules and to suggest methodological standards for their development and evaluation. DATA SOURCES Four general medical journals were manually searched for clinical prediction rules published from 1991 through 1994. STUDY SELECTION Four hundred sixty potentially eligible reports were identified, of which 30 were clinical prediction rules eligible for study. Most methodological standards could only be evaluated in 29 studies. DATA ABSTRACTION Two investigators independently evaluated the quality of each report using a standard data sheet. Disagreements were resolved by consensus. DATA SYNTHESIS The mathematical technique was used to develop the rule, and the results of the rule were described in 100% (29/29) of the reports. All the rules but 1 (97% [28/29]) were felt to be clinically sensible. The outcomes and predictive variables were clearly defined in 83% (24/29) and 59% (17/29) of the reports, respectively. Blind assessment of outcomes and predictive variables occurred in 41% (12/29) and 79% (23/29) of the reports, respectively, and the rules were prospectively validated in 79% (11/14). Reproducibility of predictive variables was assessed in only 3% (1/29) of the reports, and the effect of the rule on clinical use was prospectively measured in only 3% (1/30). Forty-one percent (12/29) of the rules were felt to be easy to use. CONCLUSIONS Although clinical prediction rules comply with some methodological criteria, for other criteria, better compliance is needed.
Root Ecology for Sustainable Agroecosystems: Intraspecific Variation in a Pan-Tropical Tree Crop

Agroecosystems that rely on higher levels of biodiversity and fewer inputs to sustain both crop production and ecosystem function require a dramatic shift away from a one-size-fits-all approach to management. Notably, this means that phenotypic expression of plants on farms cannot be assumed constant, as biotic and abiotic conditions in low-input, biodiverse agroecosystems are complex. To accurately assess and predict plant and ecosystem function in these agroecosystems, we require a more robust understanding of the drivers and consequences of intraspecific variation in plants. This includes root systems, which are arguably understudied but have a critical role in resource acquisition and use. To this end, I carried out research on the root systems of an economically important and widely cultivated tree crop, Theobroma cacao L. , in different species combinations: in monoculture or in mixture with other tree species (shade trees). I used a trait-based approach to examine how intraspecific variation in root systems relate to environment, such as the composition of species, soil resource availability, soil texture, and climate. I found that 1) species combination can influence the allocation of biomass to T. cacao root systems, with a tendency for higher root to shoot ratios when in mixture with shade trees; 2) T. cacao demonstrate nutrient-specific foraging strategies through variation in root traits at finescales within the root system, and these patterns can be influenced by shade trees; 3) T. cacao