Miracle-dz/UniFAR-FTUs huggingface dataset:
A Method of View Materialization Using Genetic Algorithm

A data warehouse is a very large database system that collects, summarizes and stores data from multiple remote and heterogeneous information sources. Data warehouses are used for supporting decision making operation on an intelligent system. The decision making queries are complex in nature and take a large amount of time when they are run against a large data warehouse. To reduce the response time, materialized views can be used. Since, all possible views cannot be materialized due to space constraints, an optimal subset of views must be selected for materialization. An approach of selecting such subsets of views using Genetic Algorithms is proposed in this paper. This approach computes the top-T views from a multidimensional lattice and calculates the fitness values for each of them.
Psychiatric Morbidity and Glycemic Control in Type 2 Non Obese Diabetic Egyptian Patients

Context: Type 2 diabetes mellitus doubles the odds of suffering from depressive illness. Objectives: The present prospective randomized controlled study aimed to estimate the prevalence of anxiety and depressive disorders among a consecutive group of patients with type 2 non obese diabetes and assess its impact on glycemic control. Subjects and Methods: We selected 200 consecutive adult patients with type 2 non obese diabetes mellitus. Patients were divided into 2 groups according to HbA1c level: >7% defined group1 with poor glycemic control (n=140) and ≤7% defined group2 with good glycemic control (n=60). All patients were assessed using semi structured Sociodemographic data form, Hospital Anxiety Depression Scale, The Mini Mental State Examination and Mini international Neuropsychiatric Interview (MINI). Results: Anxiety and depressive scores (HAD) were significantly higher in group 1 patients than in group 2 . The prevalence rate of psychiatric disorders were as follow: major depressive disorders 30.7%, dysthymic disorders 15.7% generalized anxiety disorder 10.7%, panic disorder with or without agoraphobia 10%, social anxiety disorder10%, obsessive compulsive disorder 5.7%, post traumatic stress disorder 5(3.6%) in group1 patients and major depressive disorder 18.3%, dysthymic disorder 11.7%, generalized anxiety disorder 8.3%,panic disorder with or without agoraphobia 6.7% social anxiety disorder 6.7%, obsessive compulsive disorder 5%, post traumatic stress disorder 3.3% in group2 patients . Correlation coefficient were computed among hospital anxiety depressive scores (HAD) and HbA1c level, where significant positive correlation was found between these scores and HbA1c level in the diabetic patients indicating the negative impact of depressive and anxiety disorders on glycemic control among diabetics. Conclusion: Anxiety and depressive disorders were significantly more frequent in patients with poor glycemic control (more than one third) than in those with good glycemic control. There was a strong association between HbA1c and depressive and anxiety symptoms. The presence of depressive symptoms was associated with a significant worsening of glycemic control. [Tawfik El Adl, Ashraf Talaat, Osman Elsayed, Mohammed Shahda and Mostafa Neamatallah. Psychiatric Morbidity and Glycemic Control in Type 2 Non Obese Diabetic Egyptian Patients. Life Sci J 2013;10(1):10711078] (ISSN:1097-8135). http://www.lifesciencesite. com. 166
An Empirical Test of Object-Based Output Measurement Metrics in a Computer Aided Software Engineering (Case) Environment

Existing output measurement metrics for cost estimation and development productivityneed to be re-examined to determine their performance in computer aided softwareengineering (CASE) development environments. This paper critiques and empiricallyevaluates four approaches to the measurement of outputs. Two of the metrics, rawfunction counts and function points, are based on the function point analysis methodologypioneered by Albrecht and Gaffney at IBM (ALBR83). The second two, object countsand object points, are based on a new approach -- object points analysis -- that isintroduced here for the first time. The latter metrics are specialized for outputmeasurement in object-based CASE environments that include a centralized objectrepository. Estimation results for nineteen large-scale CASE projects show that the newmetrics have the potential to yield as accurate, yet easier to obtain estimates thanfunction points-based measures.
All you can eat Buffets, obesity, mindfulness, and mindful eating: An exploratory investigation

Obesity has been mostly explained through the change in our everyday environments and the increased availability of foods. All-You-Can-Eat-Buffets (AYCEB) is a typical example of the developing ‘obesogenic’ environment, but there is a paucity of research, which fails to explore both internal and external contributing aspects to eating behaviour. In two studies, the frequency of visits at AYCEB is investigated against the Body Mass Index (BMI), psychological traits (i.e., mindfulness and selfcompassion, n=210) and eating behaviors (i.e., mindful eating, n=183) which have been found to assist weight regulation. Results indicated that frequency of visits and BMI are unrelated. Significant relationships were found only with two subscales, where buffet visits negatively correlated with awareness within mindful eating, while a positive correlation was found between buffet visits and self-kindness. While results fit within the limited literature available, the generic future applicability of mindfulness-based constructs and interventions in eating behaviours is discussed. Correspondence to: Michael Mantzios, Birmingham City University, Department of Psychology, Faculty of Business, Law and Social Sciences, Birmingham, B4 7BD, UK; E-mail: michael.mantzios@bcu.ac. uk
Epidemiologic versus Genetic Relatedness to Define an Outbreak-Associated Uropathogenic Escherichia coli Group

1. Woods CW, Cheng AC, Fowler VG Jr, et al. Endocarditis caused by Staphylococcus aureus with reduced susceptibility to vancomycin. Clin Infect Dis 2004; 38:1188–91. 2. Centers for Disease Control and Prevention (CDC). Investigation and control of vancomycin-intermediate and -resistant Staphylococcus aureus: a guide for health departments and infection control personnel. Atlanta, GA: CDC, 2004. 3. Clinical and Laboratory Standards Institute/ NCCLS. Performance standards for antimicrobial susceptibility testing: 15th informational supplement. CLSI/NCCLS document M100S15. Wayne, PA: Clinical and Laboratory Standards Institute, 2005. 4. Naimi TS, Anderson D, O’Boyle C, et al. Vancomycin-intermediate Staphylococcus aureus with phenotypic susceptibility to methicillin in a patient with recurrent bacteremia. Clin Infect Dis 2003; 36:1609–12.
Pristimantis antisuyu sp. n. and Pristimantis erythroinguinis sp. n., two new species of terrestrial-breeding frogs (Anura, Strabomantidae) from the eastern slopes of the Andes in Manu National Park, Peru.

We describe two new species of Pristimantis from the Kosñipata valley in the eastern slopes of the Andes near Manu National Park, Peru. The two new species are closely related but do not overlap elevationally: P. antisuyu sp. n. occurs from 1485-1823 m a.s. l. , whereas P. erythroinguinis sp. n. occurs from 930-1255 m a.s. l. Both species are readily distinguished from all other species of Pristimantis but P. cruciocularis and P. flavobracatus by possessing an iris with a cruciform pattern, no tympanum, and red bright or yellow coloration on groin. We used a Maximum Likelihood approach to infer a molecular phylogeny on a dataset composed of 27 terminals and 903 bp of the concatenated 16S rRNA and COI mitochondrial fragments. Our phylogenetic analyses indicate that, despite differing in groin coloration from red to yellow, individuals of P. cruciocularis and P. flavobracatus form a single clade, and some specimens have identical 16S sequences. Therefore, we synonymize P. flavobracatus with P. cruciocularis. The two unnamed species are closely related to P. cruciocularis. Pristimantis antisuyu sp. n. differs from P. cruciocularis and P. erythroinguinis sp. n. by having smaller yellow spots, instead of extensive red coloration, on groin and hind limbs, by being larger with proportionally longer tibias, and by having an inner metatarsal tubercle three times the size of outer metatarsal tubercle (twice as long in the other two species). Pristimantis erythroinguinis sp. n. , despite having coloration very similar to P. cruciocularis, is the sister taxon to both P. antisuyu sp. n. and P. cruciocularis, and can be distinguished from the latter by having much darker ventral coloration, and no cream or yellow spots on flanks and surrounding the red inguinal marks.
High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis.

USP6NL, also named RN-tre, is a GTPase-activating protein involved in control of endocytosis and signal transduction. Here we report that USP6NL is overexpressed in breast cancer, mainly of the basal-like/integrative cluster 10 subtype. Increased USP6NL levels were accompanied by gene amplification and were associated with worse prognosis in the METABRIC dataset, retaining prognostic value in multivariable analysis. High levels of USP6NL in breast cancer cells delayed endocytosis and degradation of the EGFR, causing chronic AKT (protein kinase B) activation. In turn, AKT stabilized the glucose transporter GLUT1 at the plasma membrane, increasing aerobic glycolysis. In agreement, elevated USP6NL sensitized breast cancer cells to glucose deprivation, indicating that their glycolytic capacity relies on this protein. Depletion of USP6NL accelerated EGFR/AKT downregulation and GLUT1 degradation, impairing cell proliferation exclusively in breast cancer cells that harbored increased levels of USP6NL. Overall, these findings argue that USP6NL overexpression generates a metabolic rewiring that is essential to foster the glycolytic demand of breast cancer cells and promote their proliferation.Significance: USP6NL overexpression leads to glycolysis addiction of breast cancer cells and presents a point of metabolic vulnerability for therapeutic targeting in a subset of aggressive basal-like breast tumors.Graphical Abstract: http://cancerres.aacrjournals. org/content/canres/78/13/3432/F1.large. jpg Cancer Res; 78(13); 3432-44. ©2018 AACR.
Cloudlets Authentication in NFC-Based Mobile Computing

The availability of NFC capabilities on smartphones has facilitated the development of a large number of related applications. Some of these applications may be resource-intensive tasks, and Cloudlets-based mobile computing are a good candidate to offload computation while being free of WAN delays, jitter, congestion, and failures. In this context, new use cases dedicated to NFC applications based on cloudlets are presented and a security protocol is proposed to authenticate the cloudlets by the mobile devices. The secure element of the mobile device is a trust environment used to store sensitive data and to perform cryptographic calculations.
Ultra-Low-Power (1.59 mW/Gbps), 56-Gbps PAM4 Operation of Si Photonic Transmitter Integrating Segmented PIN Mach-Zehnder Modulator and 28-nm CMOS Driver

A highly-power-efficient PAM4 silicon photonic transmitter was developed by integrating segmented PIN Mach-Zehnder modulator and CMOS inverter driver. A passive RC equalizing technique successfully enabled clear eye-opening of PAM4 signal up to 56Gbps together with a record-high-efficiency of 1.59 mW/Gbps.
Changes in Stress and Appetite Responses in Male Power-Trained Athletes during Intensive Training Camp

An intensive consecutive high-volume training camp may induce appetite loss in athletes. Therefore, this study aimed to investigate the changes in stress and appetite responses in male power-trained athletes during an intensive training camp. The measurements at Day 2 and at the end of a 9-day intensive training camp (Camp1 and Camp2, respectively) were compared with those of the resting period (Rest) and the regular training period (Regular; n = 13). The stress state was assessed based on plasma cortisol level, salivary immunoglobulin A level, and a profile of mood states score. The sensation of appetite was assessed using visual analog scale scores, and fasting plasma acylated ghrelin, insulin, and glucose were measured. The cortisol concentrations were significantly higher at Camp2 (466.7 ± 60.7 nmol∙L−1) than at Rest (356.3 ± 100.9 nmol∙L−1; p = 0.002) or Regular (361.7 ± 111.4 nmol∙L−1; p = 0.003). Both prospective and actual food consumption significantly decreased at Camp2, and acylated ghrelin concentration was significantly lower at Camp1 (34.2 ± 8.0 pg∙mL−1) and Camp2 (32.0 ± 8.7 pg∙mL−1) than at Rest (47.2 ± 11.2 pg∙mL−1) or Regular (53.4 ± 12.6 pg∙mL−1). Furthermore, the change in acylated ghrelin level was negatively correlated with the change in cortisol concentration. This study’s findings suggest that an early-phase physiological stress response may decrease the acylated ghrelin level in male power-trained athletes during an intensive training camp.
Detect Rumor and Stance Jointly by Neural Multi-task Learning

In recent years, an unhealthy phenomenon characterized as the massive spread of fake news or unverified information (i.e., rumors) has become increasingly a daunting issue in human society. The rumors commonly originate from social media outlets, primarily microblogging platforms, being viral afterwards by the wild, willful propagation via a large number of participants. It is observed that rumorous posts often trigger versatile, mostly controversial stances among participating users. Thus, determining the stances on the posts in question can be pertinent to the successful detection of rumors, and vice versa. Existing studies, however, mainly regard rumor detection and stance classification as separate tasks. In this paper, we argue that they should be treated as a joint, collaborative effort, considering the strong connections between the veracity of claim and the stances expressed in responsive posts. Enlightened by the multi-task learning scheme, we propose a joint framework that unifies the two highly pertinent tasks, i.e., rumor detection and stance classification. Based on deep neural networks, we train both tasks jointly using weight sharing to extract the common and task-invariant features while each task can still learn its task-specific features. Extensive experiments on real-world datasets gathered from Twitter and news portals demonstrate that our proposed framework improves both rumor detection and stance classification tasks consistently with the help of the strong inter-task connections, achieving much better performance than state-of-the-art methods.
Inquiring into the Differential Action of Interferons (IFNs): an IFN-α2 Mutant with Enhanced Affinity to IFNAR1 Is Functionally Similar to IFN-β

ABSTRACT Alpha and beta interferons (IFN-α and IFN-β) are multifunctional cytokines that exhibit differential activities through a common receptor composed of the subunits IFNAR1 and IFNAR2. Here we combined biophysical and functional studies to explore the mechanism that allows the alpha and beta IFNs to act differentially. For this purpose, we have engineered an IFN-α2 triple mutant termed the HEQ mutant that mimics the biological properties of IFN-β. Compared to wild-type (wt) IFN-α2, the HEQ mutant confers a 30-fold higher binding affinity towards IFNAR1, comparable to that measured for IFN-β, resulting in a much higher stability of the ternary complex as measured on model membranes. The HEQ mutant, like IFN-β, promotes a differentially higher antiproliferative effect than antiviral activity. Both bring on a down-regulation of the IFNAR2 receptor upon induction, confirming an increased ternary complex stability of the plasma membrane. Oligonucleotide microarray experiments showed similar gene transcription profiles induced by the HEQ mutant and IFN-β and higher levels of gene induction or repression than those for wt IFN-α2. Thus, we show that the differential activities of IFN-β are directly related to the binding affinity for IFNAR1. Conservation of the residues mutated in the HEQ mutant within IFN-α subtypes suggests that IFN-α has evolved to bind IFNAR1 weakly, apparently to sustain differential levels of biological activities compared to those induced by IFN-β.
Prior convictions, conduct and disposition: a scientific perspective

ABSTRACT The use of prior conduct and convictions in criminal proceedings has been a controversial issue for over a hundred years. Rarely does a year go by without another call from lawmakers or prominent citizens for prior convictions and ‘history’ to be made available to tribunals to resolve issues of guilt. Yet the debate seems to have reached an impasse, with the proponents of either side facing off at 20 paces, armed only with the familiar arguments that have failed to prevail in the past. The lack of resolution in the debate suggests that it needs to be reframed. The present article proposes a perspective based on broader scientific methodology, analysing factual decisions in a criminal trial as a form of probabilistic argument. The psychology of probabilistic reasoning is examined with a focus on the effect of attributional information on judgments of probability. The logical structures of factual reasoning about disposition, tendency, similar facts and coincidence are then put under the microscope to expose some new arguments, some weaknesses in old arguments, and some quantitative relations that affect probability judgments in this area.
A New Analytical Model to Estimate the Voltage Value and Position of the Pull-In Limit of a MEMS Cantilever

In this study, a new analytical model is developed for an electrostatic Microelectromechanical System (MEMS) cantilever actuator to establish a relation between the displacement of its tip and the applied voltage. The proposed model defines the micro-cantilever as a rigid beam supported by a hinge at the fixed-end with a spring point force balancing the structure. The approach of the model is based on calculation of the electrostatic pressure centroid on the cantilever beam to localize the equivalent electrostatic point load. Principle outcome of the model is just one formula valid for all displacements ranging from the initial to the pull-in limit position. Our model also shows that the pull-in limit position of a cantilever is approximately 44% of the initial gap. This result agrees well with both simulation results and experimental measurements reported previously. The formula has been validated by comparing the results with former empirical studies. For displacements close to the pull-in limit, the percentage errors of the formula are within 1% when compared with real measurements carried out by previous studies. The formula also gives close results (less than 4%) when compared to simulation outcomes obtained by finite element analysis. In addition, the proposed formula measures up to numerical solutions obtained from several distributed models which demand recursive solutions in structural and electrostatic domains.
Oxygen Limitation at the Larval Stage and the Evolution of Maternal Investment per Offspring in Aquatic Environments

Oxygen limitation and surface area to volume relationships of the egg were long thought to constrain egg size in aquatic environments, but more recent evidence indicates that egg size per se does not influence oxygen availability to embryos. Here, we suggest that investment per offspring is nevertheless constrained in aquatic anamniotes by virtue of oxygen transport in free-living larvae. Drawing on the well-supported assumption that oxygen limitation is relatively pronounced in aquatic versus terrestrial environments and that oxygen limitation is particularly severe in warm aquatic environments, we employ comparative methods in the Amphibia to investigate this problem. Across hundreds of species and two major amphibian clades, the slope of species mean egg diameter over habitat temperature is negative for species with aquatic larvae but is positive or neutral for species featuring terrestrial eggs and no larvae. Yet across species with aquatic larvae, the negative slope of egg diameter over temperature is similar whether eggs are laid terrestrially or aquatically, consistent with an oxygen constraint arising at the larval stage. Finally, egg size declines more strongly with temperature for species that cannot breathe aerially before metamorphosis compared with those that can. Our results suggest that oxygen transport in larvae (not eggs) constrains investment per offspring. This study further extends the generality of temperature-dependent oxygen limitation as a mechanism driving the temperature-size rule in aquatic systems.
PHARMACOGNOSTICAL AND PHYTOCHEMICAL STUDIES OF OXALIS CORNICULATA

The present study aimed to perform pharmacognostic, physicochemical and phytochemical investigations on crude powders and different types of extracts of various parts of Oxalis corniculata (Family: Oxalidaceae). The sections of different parts of the plant were stained and examined using a light microscope. Powders of different parts were also examined under light microscope. The behavior of the powders under ultraviolet light was also investigated, before and after treating with certain reagents. The powders were analyzed for the determination of proximate parameters, primary metabolites and Fourier Transform Infrared (FTIR) spectra. The extracts of different parts were investigated for primary and secondary metabolites. FTIR spectra of leaves stem and fruit showed bands at 3435–3400 cm-1 , 2918 cm1 , 1654–1651 cm-1 and 1052–1049 cm-1 , however, the fingerprint region of the spectrum indicated the difference in chemical constituents. The stained cross-sections of different parts and their powder’s microscopy, TLC profiles and primary and secondary metabolites showed distinct pharmacogostic features that could be used for identification. The observed moisture content values of leaves and stems were 5.5% and 6.0%, respectively which showed less quantity of moisture in the crude powders. The results of the present study may be used for the identification of the plant.