Miracle-dz/UniFAR-FTUs huggingface dataset:
Organizational culture in Business Process Management: The challenge of balancing disciplinary and pastoral power

Business Process Management (BPM) is a management technique which seeks to constantly innovate business processes to improve customer service while reducing costs. While much IS research has looked at the design and implementation of BPM, including its critical success factors, methodology and processes, until recently little IS research has looked at the broader organizational issues associated with BPM. This paper looks at one organizational issue in particular, that of organizational culture in BPM. Based on an action research study of one BPM project, our findings reveal that BPM’s current conceptualization of organizational culture is potentially problematic. Using Foucault’s concepts of disciplinary and pastoral power, we suggest that BPM faces a challenge in trying to balance disciplinary and pastoral power.
Hydrogen Sulfide Protects from Colitis and Restores Intestinal Microbiota Biofilm and Mucus Production

Background:Microbiota dysbiosis and impaired barrier function are among the most prominent features of inflammatory bowel disease. In the gastrointestinal tract, hydrogen sulfide (H2S) is an important regulator of mucosal homeostasis. We hypothesized that H2S promotes resolution of colonic inflammation through actions on microbiota biofilm and the mucus barrier. Methods:We used mice genetically deficient for a key enzyme for H2S production (cystathionine &ggr;-lyase) and pharmacologically inhibited that enzyme during colitis in wild-type mice. We tested the effects of administering an H2S donor (diallyl disulfide) to rodents during hapten-induced colitis. Colonic microbiota biofilm was visualized by fluorescent in situ hybridization, and mucus granules were quantified with periodic acid–alcian blue staining. We exposed human microbiota biofilms and planktonic bacteria to H2S donors ex vivo to determine changes in their growth, viability, and biomass. Results:Intestinal microbiota formed linear biofilms in the colon of healthy rodents. During colitis, microbiota biofilms were fragmented and mucus granule production decreased. Endogenous production of H2S had beneficial effects on establishment of microbiota biofilms and colonic mucus production. Therapeutic delivery of H2S into the colon reduced inflammation, restored the microbiota biofilm, and increased the production of mucus granules. In ex vivo human microbiota, H2S not only promoted biofilm formation but also reduced growth of planktonic bacteria. Conclusions:Our results suggest that H2S donors could be used therapeutically during colitis, facilitating correction of microbiota biofilm dysbiosis and mucus layer reconstitution.
Performance Measurement Of Government E-Procurement With Performance Measurement Of Government E-Procurement With Internal Stakeholder Focus Internal Stakeholder Focus

The previous literature of performance measurement of government e-procurement (or e-GP) is mainly focused on financial related performance measures and lacking of focus on overall internal stakeholders. Since objectives of public sector operation are not profitability, performance measurement of e-GP should include more extensive matters and not overlook the importance of internal stakeholders since they play important roles in success or failure in e-GP adoption and utilization. This paper aims to provide the overview of literature, the conceptual view of comprehensive e-GP performance measurement and how e-GP internal stakeholder should be addressed.
Parent Support Programs and Coping Mechanisms in NICU Parents

Background: Many neonatal intensive care unit (NICU) parents experience emotional distress leading to adverse infant outcomes. Parents may not cope positively in stressful situations, and support programs often are underutilized. Purpose: To determine coping mechanisms utilized by NICU parents, and types of support programs parents are likely to attend. To determine whether sociodemographic and length-of-stay differences impact coping mechanisms utilized, and types of support programs preferred. Methods: A correlational cross-sectional survey design was used. The 28-item Brief COPE tool, questions about demographics and preferred support program styles, was distributed to a convenience sample of NICU parents in a level IV NICU in the southeastern United States. Results: One hundred one NICU parents used coping mechanisms, with acceptance emotional support, active coping, positive reframing, religion, planning, and instrumental support being the most common. Preferred support classes were infant development and talking with other NICU parents. Caucasians more commonly coped using active coping, planning, emotional support, acceptance, instrumental support, and venting compared with other races. Women utilized self-blame coping mechanisms more often compared with men. Younger parents were more likely to use venting and denial coping mechanisms. Parents with a shorter stay utilized self-distraction coping and preferred the class of talking with other parents. Implications for Practice: Support program preference, type of coping mechanism utilized, and sociodemographic factors may be used to guide the creation of NICU support programs. Implications for Research: Additional studies are needed to determine whether support program offering according to preferences and sociodemographic characteristics increases attendance and decreases emotional distress.
Importance of Domain Closure for the Catalysis and Regulation ofEscherichia coli Aspartate Transcarbamoylase*

Two hybrid versions ofEscherichia coli aspartate transcarbamoylase were studied to determine the influence of domain closure on the homotropic and heterotropic properties of the enzyme. Each hybrid holoenzyme had one wild-type and one inactive catalytic subunit. In the first case the inactive catalytic subunit had Arg-54 replaced by alanine. The holoenzyme with this mutation in all six catalytic chains exhibits a 17,000-fold reduction in activity, no loss in substrate affinity, and an R state structurally identical to that of the wild-type enzyme. In the second case, the inactive catalytic subunit had Arg-105 replaced by alanine. The holoenzyme with this mutation in all six catalytic chains exhibits a 1,100-fold reduction in activity, substantial loss in substrate affinity, and loss of the ability to be converted to the R state. Thus, the R54A substitution results in a holoenzyme that can undergo closure of the catalytic chain domains to form the high activity, high affinity active site and to undergo the allosteric transition, whereas the R105A substitution results in a holoenzyme that can neither undergo domain closure nor the allosteric transition. The hybrid holoenzyme with one wild-type and one R54A catalytic subunit exhibited the same maximal velocity per active site as the wild-type holoenzyme, reduced cooperativity, and normal heterotropic interactions. The hybrid with one wild-type and one R105A catalytic subunit exhibited significantly reduced maximal velocity per active site as compared with the wild-type holoenzyme, reduced cooperativity, and substantially reduced heterotropic interactions. Small angle x-ray scattered was used to verify that the R105A-containing hybrid could attain an R state structure. These results indicate the global nature of the conformational changes associated with the allosteric transition in the enzyme. If one catalytic subunit cannot undergo domain closure to create the active sites, then the entire molecule cannot attain the high activity, high activity R state.
Arquitecturas de comunicaciones para la computacióon algorítmica en poblaciones de bacterias multi-cepa

Esta Tesis establece su desarrollo en el area interdisciplinar de la biologia sintetica y, mas concretamente, la computacion con bacterias. La union entre la biologia y las ciencias de la computacion tiene su raiz a mediados del siglo XX, siendo la biologia una importante fuente de inspiracion para desarrollar diferentes paradigmas de computo en analogia directa a los seres vivos. Sin embargo, no ha sido hasta finales del mismo siglo y principios del XXI cuando el fujo de inspiracion cambio de rumbo y se empezaron a construir dispositivos moleculares que actuaran como rudimentarios computadores desempenando tareas de calculo logico definidas. La suma de otra disciplina, la ingenieria, ayuda a abordar el diseno de estos biosistemas como una tarea formalizada de conguracion de componentes. Al observar y entender una bacteria como un sistema cuya maquinaria esta formada por un conjunto de piezas funcionales diferentes, surge el objetivo de alterar los mecanismos naturales de las bacterias con el fin de construir sistemas vivos con funcionalidades no naturales. Los algoritmos aqui especificados estan disenados para llevarse a cabo en comunidades de bacterias formadas por mas de una cepa, para lo cual la presente Tesis propone arquitecturas de comunicaciones diversas que ayuden a la sincronizacion necesaria entre bacterias distintas, basandose para ello en las capacidades y mecanismos de comunicacion que las bacterias muestran en estado natural, como son la conjugacion bacteriana y el quorum sensing. Esta Tesis propone la modificacion y manipulacion de estos mecanismos para conseguir computaciones con rudimentarios sistemas de toma de decisiones y que, en un futuro, puedan servir al desarrollo de aplicaciones en campos cienticos tan diversos como la medicina o la ecologia. Entre los ejemplos de coomputo a los que se someten las nuevas arquitecturas disenadas caben destacar problemas complejos (TSP, SAT) y un oscilador poblacional en el que una comunidad heterogenea de bacterias muestra oscilacion unica. Es importante enfatizar que uno de los principales objetivos de la Tesis es la validacion, tanto biologica (conocimiento experto) como computacional (simulacion) de los modelos disenados. Ya que la Tesis tiene caracter eminentemente teorico, se lleva a cabo un fuerte proceso de validacion que asegure en un porcentaje muy alto el exito de la -futura- experimentacion en laboratorio con estos disenos.
Detecting misbehaviour in a complex system-of-systems environment

Modern systems are becoming increasingly complex, integrated and distributed, in order to meet the escalating demands for functionality. This has given rise to concepts such as system-of-systems (SoS), which organise a myriad of independent component systems into a collaborative super-system, capable of achieving unmatchable levels of functionality. Despite its advantages, SoS is still an infantile concept with many outstanding security concerns, including the lack of effective behavioural monitoring. This can be largely attributed to its distributed, decentralised and heterogeneous nature, which poses many significant challenges. The uncertainty and dynamics of both the SoS’s structure and function poses further challenges to overcome. Due to the unconventional nature of a SoS, existing behavioural monitoring solutions are often inadequate as they are unable to overcome these challenges. This monitoring deficiency can result in the occurrence of misbehaviour, which is one of the most serious yet underestimated security threats facing SoSs and their components. This thesis presents a novel misbehaviour detection framework specifically developed for operation in a SoS environment. By combining the use of uniquely calculated behavioural threshold profiles and periodic threshold adaptation, the framework is able to cope with monitoring the dynamic behaviour and suddenly occurring changes that affect threshold reliability. The framework improves SoS contribution and monitoring efficiency by controlling monitoring observations using statecharts, which react to the level of behavioural threat perceived by the system. The accuracy of behavioural analysis is improved by using a novel algorithm to quantify detected behavioural abnormalities, in terms of their level of irregularity. The framework utilises collaborative behavioural monitoring to increase the accuracy of the behavioural analysis, and to combat the threat posed by training based attacks to the threshold adaptation process. The validity of the collaborative behavioural monitoring is assured by using the novel behavioural similarity assessment algorithm, which selects the most behaviourally appropriate SoS components to collaborate with. The proposed framework and its subsequent techniques are evaluated via numerous experiments. These examine both the limitations and relative merits when compared to monitoring solutions and techniques from similar research areas. The results of these conclude that the framework is able to offer misbehaviour monitoring in a SoS environment, with increased efficiency and reduced false positive rates, false negative rates, resource usage and run-time requirements.
UV-extending ghost inflation

We present a setup that provides a partial UV-completion of the ghost inflation model up to a scale which can be almost as high as the Planck mass. This is achieved by coupling the inflaton to the Lorentz-violating sector described by the Einstein-aether theory or its khronometric version. Compared to previous works on ghost inflation our setup allows to go beyond the study of small perturbations and include the background dynamics in a unified framework. In the specific regime when the expansion of the Universe is dominated by the kinetic energy of the inflaton we find that the model predicts rather high tensor-to-scalar ratio r ∼ 0.02÷0.2 and non-Gaussianity of equilateral type with fNL in the range from -50 to -5.
Comparison of fat oxidation during exercise in lean and obese pubertal boys: clinical implications

Objective: To examine fat oxidation rates during exercise in lean and obese pubescent children. Design: A graded leg cycle ergometry test was performed by two groups of pubescent boys (13 lean: mean (SD) age 12.0 (0.5) years, body mass index (BMI) 18.56 (1.12) kg/m2; 17 obese: mean (SD) age 12.1 (0.1) years, BMI 26.68 (3.37) kg/m2; p<0.001). The first step of the test was fixed at 30 W and power was gradually increased by 20 W every 3.5 min. The mean ventilatory gas measurement was obtained during the last 30 s of each step for calculation of fat oxidation rate vs exercise intensity. Results: At low intensity (0–30% of peak oxygen consumption) when fat-free mass is considered, the fat oxidation rate was identical for the two groups. At higher intensities (40%, 50% and 60% of peak oxygen consumption) the fat oxidation rate was significantly higher in lean boys than in obese boys. Conclusion: These results confirm that obese pubertal boys have fat-free mass decreased capacities to use fat during moderate exercise. The findings suggest that obese boys need to practise physical activity at a lower intensity than healthy boys to enhance lipolysis and diminish adipose tissue and the consequences of obesity.
Genetic Parameters for Milk Somatic Cell Score and Relationships with Production Traits in Primiparous Dairy Sheep

A total of 13,066 first-lactation test-day records of 2,277 Valle del Belice ewes from 17 flocks were used to estimate genetic parameters for somatic cell scores (SCS) and milk production traits, using a repeatability test-day animal model. Heritability estimates were low and ranged from 0.09 to 0.14 for milk, fat, and protein yields, and contents. For SCS, the heritability of 0.14 was relatively high. The repeatabilities were moderate and ranged from 0.29 to 0.47 for milk production traits. The repeatability for SCS was 0.36. Flock-test-day explained a large proportion of the variation for milk production traits, but it did not have a big effect on SCS. The genetic correlations of fat and protein yields with fat and protein percentages were positive and high, indicating a strong association between these traits. The genetic correlations of milk production traits with SCS were positive and ranged from 0.16 to 0.31. The results showed that SCS is a heritable trait in Valle del Belice sheep and that single-trait selection for increased milk production will also increase SCS.
Evaluation of the “Lose Your Excuse” Public Service Advertising Campaign for Tweens to Save Energy

This study evaluates the 2008–2009 “Lose your Excuse” public service advertising (PSA) campaign on energy efficiency targeting 8- to 12-year-olds, intended to increase knowledge, foster proactive attitudes, and change energy usage behaviors. Baseline and two follow-up surveys were conducted with online samples representative of the national population of households with kids with online access. Almost half (47%) of the tweens recognized at least one ad from the campaign. Ad recognition was positively associated with knowledge, proactive attitudes, and energy-saving behavior. Propensity score analysis confirmed a small but measurable and statistically significant effect on energy-saving behavior. The discussion section compares these results to public health campaigns in terms of ghost awareness, reach, and effect size.
Segond fracture combined with tibial plateau fracture.

OBJECTIVE The objective of our study was to examine the coexistence of Segond fracture in tibial plateau fractures and to assess the prevalence of anterior cruciate ligament (ACL) rupture and meniscal tear when those fractures coexist. MATERIALS AND METHODS This retrospective study was conducted at a level 1 trauma center. A total of 1203 emergency department knee trauma MDCT examinations were evaluated. Surgical findings served as the reference standard for intraarticular injuries. RESULTS A total of 33 patients with a Segond fracture were found. Of these patients, 10 had isolated Segond fractures (surgery, n = 7) and 23 patients (surgery, n = 20) had a Segond fracture associated with a tibial plateau fracture. Patients with both fractures had significantly fewer anterior cruciate ligament (ACL) ruptures (20% vs 71%, p = 0.023) and more avulsion fractures of the ACL (50% vs 0%, p = 0.026) than patients with isolated Segond fractures. For meniscal injuries, the corresponding numbers were 25% and 57% (p = 0.175), respectively. In approximately one of every 32 tibial plateau fractures, a Segond fracture also coexists. CONCLUSION Patients with a Segond fracture combined with a tibial plateau fracture have a high risk of avulsion fracture of the ACL.
Quantification of short-chain fatty acids in cecal material by gas chromatography-mass spectrometry

v INTRODUCTION 1 1. Gastrointestinal tract (GI) 1 2. Microbiota in Humans 2 3. Health benefits of short chained fatty acids 3 4. Sources of SCFA production 5 5. Analysis of SCFA of gas chromatography/mass spectrometry 7 6. Gas chromatography mass spectrometric detection of analytes 8 7. Use of mouse model system 9 EXPERIMENTAL PROCEDURES 10 1. Preparation of standards 10 2. Preparation of pentaflouro benzyl bromide esters of fatty acids 10 3. Hydroxyl fatty acid analysis 11 4. Conversion of hydroxyl fatty acids to their (bis)-TMS ester derivatives by use of BSTFA 11
Diverse Economies of Collective Value Co-creation: The Open Monuments Event

ABSTRACT Diverse economies research provides understanding and action about the coexistence of dominant forms of capitalism and economic organisation with non-capitalist spaces, where organisations and society can create value beyond a monetised economy. This study explores the collective value generated by the interactions of multiple actors who perform a cultural tourism event in Sardinia, Italy, through which alternative spaces of value creation and value appropriation have emerged. By adopting an interpretive stance, and community case study research strategies, a panel of 26 key informants were involved in the investigation in-situ. We found that conflict and negotiation reshaped actors’ roles and brings innovation and social change. Due to the direct stakeholders’ engagement by symmetric interactions and collaborative practices, actors co-create value through a mix of social, cultural, economic, and environmental mechanisms, and generate outcomes such as the enhancement of social capital, and local resilience.
Apprentissage de grammaires catégorielles : transducteurs d’arbres et clustering pour induction de grammaires catégorielles

De nos jours, il n’est pas rare d’utiliser des logiciels capables d’avoir une conversation, d’interagir avec nous (systemes questions/reponses pour les SAV, gestion d’interface ou simplement Intelligence Artificielle - IA - de discussion). Ceux-ci doivent comprendre le contexte ou reagir par mot-clefs, mais generer ensuite des reponses coherentes, aussi bien au niveau du sens de la phrase (semantique) que de la forme (syntaxe). Si les premieres IA se contentaient de phrases toutes faites et reagissaient en fonction de mots-clefs, le processus s’est complexifie avec le temps. Pour ameliorer celui-ci, il faut comprendre et etudier la construction des phrases. Nous nous focalisons sur la syntaxe et sa modelisation avec des grammaires categorielles. L’idee est de pouvoir aussi bien generer des squelettes de phrases syntaxiquement correctes que verifier l’appartenance d’une phrase a un langage, ici le francais (il manque l’aspect semantique). On note que les grammaires AB peuvent, a l’exception de certains phenomenes comme la quantification et l’extraction, servir de base pour la semantique en extrayant des λ-termes. Nous couvrons aussi bien l’aspect d’extraction de grammaire a partir de corpus arbores que l’analyse de phrases. Pour ce faire, nous presentons deux methodes d’extraction et une methode d’analyse de phrases permettant de tester nos grammaires. La premiere methode consiste en la creation d’un transducteur d’arbres generalise, qui transforme les arbres syntaxiques en arbres de derivation d’une grammaire AB. Applique sur les corpus francais que nous avons a notre disposition, il permet d’avoir une grammaire assez complete de la langue francaise, ainsi qu’un vaste lexique. Le transducteur, meme s’il s’eloigne peu de la definition usuelle d’un transducteur descendant, a pour particularite d’offrir une nouvelle methode d’ecriture des regles de transduction, permettant une definition compacte de celles-ci. Nous transformons actuellement 92,5% des corpus en arbres de derivation. Pour notre seconde methode, nous utilisons un algorithme d’unification en guidant celui-ci avec une etape preliminaire de clustering, qui rassemble les mots en fonction de leur contexte dans la phrase. La comparaison avec les arbres extraits du transducteur donne des resultats encourageants avec 91,3% de similarite. Enfin, nous mettons en place une version probabiliste de l’algorithme CYK pour tester l’efficacite de nos grammaires en analyse de phrases. La couverture obtenue est entre 84,6% et 92,6%, en fonction de l’ensemble de phrases pris en entree. Les probabilites, appliquees aussi bien sur le type des mots lorsque ceux-ci en ont plusieurs que sur les regles, permettent de selectionner uniquement le “meilleur” arbre de derivation.Tous nos logiciels sont disponibles au telechargement sous licence GNU GPL.