Miracle-dz/UniFAR-FTUs huggingface dataset:
Potential of support-vector regression for forecasting stream flow

Original scientific paper Stream flow is an important input for hydrology studies because it determines the water variability and magnitude of a river. Water resources engineering always deals with historical data and tries to estimate the forecasting records in order to give a better prediction for any water resources applications, such as designing the water potential of hydroelectric dams, estimating low flow, and maintaining the water supply. This paper presents three soft-computing approaches for dealing with these issues, i.e. artificial neural networks (ANNs), adaptive-neuro-fuzzy inference systems (ANFISs), and support vector machines (SVMs). Telom River, located in the Cameron Highlands district of Pahang, Malaysia, was used in making the estimation. The Telom River’s daily mean discharge records, such as rainfall and river-level data, were used for the period of March 1984 – January 2013 for training, testing, and validating the selected models. The SVM approach provided better results than ANFIS and ANNs in estimating the daily mean fluctuation of the stream’s flow.
Measures to Assess Maladaptive Variants of the Five-Factor Model

The five-factor model (FFM) is the predominant dimensional model of general personality structure. A considerable body of research supports the hypothesis that personality disorders can be conceptualized as extreme or maladaptive variants of the domains and facets of the FFM. However, existing measures of the FFM are confined largely to the normal variants. The purpose of this special section of the Journal of Personality Assessment is to provide the development and initial validation of self-report inventory scales to assess obsessive–compulsive, borderline, narcissistic, avoidant, and dependent personality traits from the perspective of the FFM, which complement the similarly constructed existing measures for psychopathic, histrionic, and schizotypal personality traits.
Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPα but not importin α

Replication protein A (RPA) is a eukaryotic single‐stranded (ss) DNA‐binding protein that is essential for general DNA metabolism. RPA consists of three subunits (70, 33 and 14 kDa). We have identified by two‐hybrid screening a novel Xenopus protein called XRIPα that interacts with the ssDNA‐binding domain of the largest subunit of RPA. XRIPα homologues are found in human and in Drosophila but not in yeast. XRIPα is complexed with RPA in Xenopus egg extracts together with another 90 kDa protein that was identified as importin β. We have demonstrated that XRIPα, but not importin α, is required for nuclear import of RPA. Immunodepletion of XRIPα from the egg extracts blocks nuclear import of RPA but not that of nucleoplasmin, a classical import substrate. RPA import can be restored by addition of recombinant XRIPα. Conversely, depletion of importin α blocks import of nucleoplasmin but not that of RPA. GST–XRIPα pull‐down assay shows that XRIPα interacts directly with recombinant importin β as well as with RPA in vitro. Finally, RPA import can be reconstituted from the recombinant proteins. We propose that XRIPα plays the role of importin α in the RPA import scheme: XRIPα serves as an adaptor to link RPA to importin β.
Corporate Governance and Innovation: a conceptual approach

This paper deals with the relationship between innovation and corporate governance. Corporate governance is relevant for innovation, because the characteristics of innovative investment strategies are dependent on the incentives and abilities of the stakeholders who are in control. The purpose of this research is to analyse the relevance and meaning of existing and new/adapted corporate governance institutions at the firm level in capturing and exploring new technological opportunities and in facilitating innovation and organizational learning. Hypotheses are formulated which relate specific innovation dimensions to corporate governance institutions on the firm level
Long-term monaural auditory deprivation and bilateral cochlear implants

Long-term binaural auditory deprivation is associated with poorer speech recognition outcomes after cochlear implantation, even for postlingual hearing loss. It is, however, unknown to what extent the outcomes of implantation are related to the peripheral changes occurring monaurally or to changes at a higher level in the auditory system related to binaural deafness. This retrospective study aimed to unravel peripheral and central contributions to cochlear implantation outcomes by comparing outcomes obtained in individual ears for adults with long-term monaural auditory deprivation (i.e. unilateral use of hearing aid) who received bilateral cochlear implants. Results showed that similar outcomes can be obtained with the implant placed in the auditory-deprived or in the aided ear. This suggests that the peripheral changes related to monaural auditory deprivation have little effect on outcomes of cochlear implantation.
User interest visualizing and analysing system using eye gaze

Eye tracking technology is useful to provide faster and more intuitive control interface. Thus, eye tracking is popular in evaluating contents such as advertisements. It have helped researchers to analyse the user's attention and it finally makes more contents better. This paper introduced the system for visualizing and analysing user's gaze information. Detailed implementation of the proposed system and its capabilities are presented along with usage examples. This system can be applied to various fields such as analysis of driver attention, web page layout, advertisement effectiveness, product sales, and so on.
Unexplained physical symptoms: outcome, utilization of medical care and associated factors

Synopsis The aim of the study was to investigate the recovery and frequency of physician contact in patients with unexplained physical symptoms and to identify factors associated with persistent disorder. Of 100 consecutive patients who presented with medically unexplained symptoms to a general medical out-patient clinic, 81 participated in a follow-up study. The mean follow-up time was 15·2 months (S.D. 4·0). At follow-up, many of the patients with unexplained physical symptoms reported that they had recovered (30%) or improved (46%) with regard to their presenting symptoms. Female sex and a high number of symptoms predicted a bad outcome in terms of recovery. Persistence of symptoms was not related to the duration of the symptoms, type of presenting complaint or the presence of psychiatric disorder. Forty per cent of patients with unexplained symptoms did not visit their general practitioner on their own initiative in the year following the initial visit to the clinic. Medical care utilization appeared to be associated with female sex, age, number and duration of symptoms, fatigue and psychiatric disorder, especially somatoform disorders. However, the association of a high frequency of physican contact with female sex and psychiatric disorder was not sustained after controlling for possible confounding factors.
Observation of the seafloor acoustic ranging system

We developed the seafloor acoustic ranging system to monitor the seafloor crustal movement. In 2008 September we carried out an observation to monitor the active splay faults on Kumano-Nada prism slope. We deployed three PXPs with about 925 m (M1-S2 baseline) and 725 m (M1-S2 base line) spacing at the depth of 2880 m. We recovered three PXPs in 2010 August. Data set is the acoustic measurement for 6 month and the pressure measurement for 18 month In March 2009, very low frequency earthquake activity near the experiment area was observed by OBSs, which was deployed by JAMSTEC and ERI. We didn't observe the change of baselines in this system. Therefore we have a assumption that there was no crustal movement that exceeds the detection sensitivity in this event.
Expression of N‐methyl D‐aspartate receptor subunits in amoeboid microglia mediates production of nitric oxide via NF‐κB signaling pathway and oligodendrocyte cell death in hypoxic postnatal rats

The present study was focused on identifying the expression of N‐methyl D‐aspartate receptor (NMDAR) subunits on activated microglia and to determine their role in the pathogenesis of periventricular white matter damage (PWMD) in neonatal rats following hypoxia. One day old wistar rats were subjected to hypoxia (5% O2; 95% N2) and the mRNA and protein expression of NMDAR subunits (NR1, NR2A‐D, and NR3A) in the periventricular white matter (PWM) was determined at different time points (3,24 h, 3, 7, and 14 days) following hypoxic exposure. Immunoexpression of NR1 and NR2A‐D was localized in amoeboid microglial cells (AMC) suggesting the presence of functional NMDARs in them. The expression of NMDAR in primary microglial cultures was ascertained by RT‐PCR analysis and double immunofluorescence studies. The functionality of the microglial NMDAR in cultured microglial cells was examined by monitoring calcium movements in cells with fura‐2. In primary microglial cultures, hypoxia induced the nuclear translocation of NF‐κB which was suppressed by administration of MK801, an NMDAR antagonist. MK801 also down regulated the hypoxia‐induced expression of tumor necrosis factor‐α, interleukin‐1β, inducible nitric oxide synthase (iNOS), and nitric oxide (NO) production by microglia which may be mediated by the NF‐κB signaling pathway. NO produced by microglia is known to cause death of oligodendrocytes in the developing PWM. In this connection, pharmacological agents such as MK801, BAY (NF‐κB inhibitor), and 1400w (iNOS inhibitor) proved to be beneficial since they reduced the hypoxia‐induced iNOS expression, NO production, and a corresponding reduction in the death of oligodendrocytes following hypoxia. © 2011 Wiley‐Liss, Inc.
On molecular approximation algorithms for NP optimization problem

We develop a general technique for constructing molecular-based approximation algorithms for NP optimization problems. Our algorithms exhibit a useful volume{ accuracy tradeoo. In particular we solve the Covering problem of Hochbaum and Maass using polynomial time and O ` 2 (log`)n 2 ? n(n? 1) ` 2 =2 volume with error ratio (1 + 1 `) 2. We also present the rst candidate for a problem that can be solved more eeciently with the Amplify operation than without.
A Study of HRM Practices and Organizational Culture in Selected Private Sector Organizations in India

This paper examined the relationship between HRM practices and organizational culture in private sector organizations operating in India. Organizational culture has developed in the Indian environment along with global work values. This study is based on a survey of 95 respondents working in two private sector organizations. Although the HRM practices in these organizations differ a lot, there is a significant relationship between HRM practices and organizational culture.
Conduction-type dependence of thermal oxidation rate on SiC(0001)

The conduction-type dependent thermal oxidation rate in SiC was discovered. The oxidation was performed for SiC(0001) with nitrogen doping (n-type) in the range from 2.0×10<sup>16</sup> cm<sup>-3</sup> to 1.0×10<sup>19</sup> cm<sup>-3</sup>, and aluminum doping (p-type) in the range from 2.0×10<sup>15</sup> cm<sup>-3</sup> to 1.0×10<sup>19</sup> cm<sup>-3</sup>, exhibiting a clear dependence. For n-type SiC the oxide thickness increases for higher doping density, and for p-type the thickness decreases. Note that in the case of Si oxidation, there exists very little difference of oxidation rate between the conduction types in such low doping density, and the dependence is peculiar to SiC. The authors speculate the difference originates from the difference in carrier (electron/hole) density during the oxidation, which can reasonably explain the difference in the oxidation rate between Si and SiC.
Adverse effect of tannery waste leachates in transgenic Drosophila melanogaster: role of ROS in modulation of Hsp70, oxidative stress and apoptosis

Leachate is a complex chemical mixture of chemicals produced as a result of leaching of solid wastes. The potential toxicity of leachates is a major environmental health concern. The present study evaluated the role of ROS in tannery leachates induced Hsp70 expression, antioxidant enzymes and apoptosis in Drosophila. Different concentrations (0.05–2.0%) of leachates prepared from tannery waste at different pH (7.00, 4.93 and 2.88) were mixed with Drosophila food and fed to the larvae for 2–48 h to examine the different stress and apoptotic markers. A concentration‐ and time‐dependent significant increase in Hsp70 expression, ROS generation, antioxidant enzymes activities and MDA content were observed in the exposed larvae. Activities of antioxidant enzymes were delayed compared with Hsp70 expression and MDA level in the exposed organisms. Apoptotic cell death was observed in the exposed larvae at higher concentrations concurrent with a significant regression in Hsp70 along with a higher level of ROS generation. A positive correlation drawn between ROS generation and apoptotic markers and a negative correlation between apoptotic markers and Hsp70 expression at these concentrations indicated the important role of ROS in the induction of cellular damage in the exposed organisms. There was a significant generation of ROS in the larvae exposed to 0.5% of leachates which did not interfere with the protection of their cells by Hsp70 and antioxidant enzymes. However, generation of significantly higher levels of ROS in the larvae exposed to 1.0% and 2.0% leachates may decrease Hsp70 expression thus leading to mitochondria‐mediated caspase‐dependent apoptotic cell death. Copyright © 2008 John Wiley & Sons, Ltd.
PTB Regulates the Processing of a 3′-Terminal Exon by Repressing both Splicing and Polyadenylation

ABSTRACT The polypyrimidine tract binding protein (PTB) has been described as a global repressor of regulated exons. To investigate PTB functions in a physiological context, we used a combination of morpholino-mediated knockdown and transgenic overexpression strategies in Xenopus laevis embryos. We show that embryonic endoderm and skin deficient in PTB displayed a switch of the α-tropomyosin pre-mRNA 3′ end processing to the somite-specific pattern that results from the utilization of an upstream 3′-terminal exon designed exon 9A9′. Conversely, somitic targeted overexpression of PTB resulted in the repression of the somite-specific exon 9A9′ and a switch towards the nonmuscle pattern. These results validate PTB as a key physiological regulator of the 3′ end processing of the α-tropomyosin pre-mRNA. Moreover, using a minigene strategy in the Xenopus oocyte, we show that in addition to repressing the splicing of exon 9A9′, PTB regulates the cleavage/polyadenylation of this 3′-terminal exon.
The relationship between the task and ego orientations & coping strategies among universities athletes.

The present study investigated the relationship between goal orientations (task and ego) and psychological coping skills among University's athletes. Participants were 85 athletes, both male (n=35) and female (n = 50) aged between 19 and 28 years old who represented one of the largest university in the central of Malaysia in various sports competitions. Participants completed the Task and Ego Orientation in Sport Questionnaire (TEOSQ) to measure goal orientation while psychological coping skills were measured using Athletic Coping Skills Inventory (ACSI) - 28. results showed that there is a moderate relationship between goal orientations and psychological coping skills, with ego orientation showing a stronger relationship than task orientation. Moreover, the results showed that the athletes have both high task (mean=3.97) and fairly high ego orientations (mean=3.71), and there was no significant differences between males and females in goal orientations (p> .05). The results found that ego orientation was significantly correlated with all the six coping skills (p< .01) but task orientation was significantly correlated with only five coping skills (p< .01) as freedom from worry was not significantly correlated with task orientation. The results on the relationship between gender and psychological coping skills found that females were more likely to use concentration and peaking under pressure, whereas male athletes used freedom from worry as their coping responses. The study also found that there is a significant relationship between the athlete's goal orientation and his/her psychological coping skills.
Nonlinear basic stability concept of the hybrid position/force control scheme for robot manipulators

The basic stability characteristics of the nonlinear hybrid control system are clarified by using Lyapunov's method in relation to autonomous systems. The fundamental stability condition of hybrid control is evaluated by using a hybrid control scheme, the friction effect, an additional phase lag (dead time), and the digital control effect. The sampling delay (dead time) causes a large additional phase lag, which in turn causes instability. Moreover, the stability results confirm that the hybrid control scheme and digital control effect adversely affect hybrid control stability even if the fundamental stability condition is satisfied. >
Greedy algorithms for prediction

In many prediction problems, it is not uncommon that the number of variables used to construct a forecast is of the same order of magnitude as the sample size, if not larger. We then face the problem of constructing a prediction in the presence of potentially large estimation error. Control of the estimation error is either achieved by selecting variables or combining all the variables in some special way. This paper considers greedy algorithms to solve this problem. It is shown that the resulting estimators are consistent under weak conditions. In particular, the derived rates of convergence are either minimax or improve on the ones given in the literature allowing for dependence and unbounded regressors. Some versions of the algorithms provide fast solution to problems such as Lasso.
N-glycoproteomic analysis of human follicular fluid during natural and stimulated cycles in patients undergoing in vitro fertilization

Objective Hyperstimulation methods are broadly used for in vitro fertilization (IVF) in patients with infertility; however, the side effects associated with these therapies, such as ovarian hyperstimulation syndrome (OHSS), have not been well studied. N-glycoproteomes are subproteomes used for the remote sensing of ovarian stimulation in follicular growth. Glycoproteomic variation in human follicular fluid (hFF) has not been evaluated. In this study, we aimed to identify and quantify the glycoproteomes and N-glycoproteins (N-GPs) in natural and stimulated hFF using label-free nano-liquid chromatography/electrospray ionization-quad time-of-flight mass spectrometry. Methods For profiling of the total proteome and glycoproteome, pooled protein samples from natural and stimulated hFF samples were selectively isolated using hydrazide chemistry to obtain the total proteomes and glycoproteomes. N-GPs were validated by the consensus sequence N-X-S/T (92.2% specificity for the N-glycomotif at p<0.05). All data were compared between natural versus hyperstimulated hFF samples. Results We detected 41 and 44 N-GPs in the natural and stimulated hFF samples, respectively. Importantly, we identified 11 N-GPs with greater than two-fold upregulation in stimulated hFF samples compared to natural hFF samples. We also validated the novel N-GPs thyroxine-binding globulin, vitamin D-binding protein, and complement proteins C3 and C9. Conclusion We identified and classified N-GPs in hFF to improve our understanding of follicular physiology in patients requiring assisted reproduction. Our results provided important insights into the prevention of hyperstimulation side effects, such as OHSS.
Scale-Free Networks

A variety of different social, natural, and technological systems can be described by the same mathematical framework. This holds from the Internet to food webs and to boards of company directors. In all these situations a graph of the elements of the system and their interconnections displays a universal feature. There are only few elements with many connections, and many elements with few connections. This book presents the experimental evidence of these 'scale-free networks' and provides students and researchers with a corpus of theoretical results and algorithms to analyse and understand these features. The content of this book and the exposition makes it a clear textbook for beginners, and a reference book for the experts.
Tanshinone Inhibits NSCLC by Downregulating AURKA Through Let-7a-5p

Lung cancer is the most deadly malignancy in the last decade, accounting for about 1.6 million deaths every year globally. Tanshinone is the constituent of Salvia miltiorrhiza; it has been found that they influence tumorigenesis. However, the role of tanshinones on lung cancer is still not clear. Let-7a-5p, a short non-coding RNA, is regarded as a suppressor gene in tumorigenesis. Herein, we verified that let-7a-5p is significantly downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Tanshinone suppressed the expression of aurora kinase A (AURKA), inhibited cell proliferation, and arrested cell cycle progression. Our results showed that tanshinones suppressed NSCLC by upregulating the expressions of let-7a-5p via directly targeting AURKA. Besides, the data reveal that the knockdown of AURKA can also inhibit cell proliferation, arrest cell cycle, and promote cell apoptosis. Furthermore, this study demonstrates that AURKA was negatively correlated with let-7a-5p in NSCLC patient tissues. Taken together, our findings suggest that tanshinone inhibits NSCLC by downregulating AURKA through let-7a-5p. Tanshinones and let-7a-5p have the potential to be candidates for drug development of NSCLC. In conclusion, this study revealed that tanshinones with miRNA linking lead to partial mechanism in NSCLC.
Incorporating risk into business process models

Although business process modeling is considered as a core activity in enterprise risk management, existing process modeling languages do not include a complete notation for documenting how processes can fail. This paper develops a conceptual framework for extending standard business process metamodels to include comprehensive information that is useful for managing and quantifying operational risk in business processes. We provide formal extensions of the Business Process Modeling Notation standard, as well as a step-by-step process for creating a risk-extended process model.
Investigating Degradation Mechanisms in 130 nm and 90 nm Commercial CMOS Technologies Under Extreme Radiation Conditions

The purpose of this paper is to study the mechanisms underlying performance degradation in 130 nm and 90 nm commercial CMOS technologies exposed to high doses of ionizing radiation. The investigation has been mainly focused on their noise properties in view of applications to the design of low-noise, low-power analog circuits to be operated in harsh environment. Experimental data support the hypothesis that charge trapping in shallow trench isolation (STI), besides degrading the static characteristics of interdigitated NMOS transistors, also affects their noise performances in a substantial fashion. The model discussed in this paper, presented in a previous work focused on CMOS devices irradiated with a 10 Mrad(SiO2) gamma -ray dose, has been applied here also to transistors exposed to much higher (up to 100 Mrad(SiO2 )) doses of X-rays. Such a model is able to account for the extent of the observed noise degradation as a function of the device polarity, dimensions and operating point.