Miracle-dz/UniFAR-FTUs huggingface dataset:
Incremental information gain analysis of input attribute impact on RBF-kernel SVM spam detection

The massive increase of spam is posing a very serious threat to email and SMS, which have become an important means of communication. Not only do spams annoy users, but they also become a security threat. Machine learning techniques have been widely used for spam detection. Email spams can be detected through detecting senders' behaviour, the contents of an email, subject and source address, etc, while SMS spam detection usually is based on the tokens or features of messages due to short content. However, a comprehensive analysis of email/SMS content may provide cures for users to aware of email/SMS spams. We cannot completely depend on automatic tools to identify all spams. In this paper, we propose an analysis approach based on information entropy and incremental learning to see how various features affect the performance of an RBF-based SVM spam detector, so that to increase our awareness of a spam by sensing the features of a spam. The experiments were carried out on the spambase and SMSSpemCollection databases in UCI machine learning repository. The results show that some features have significant impacts on spam detection, of which users should be aware, and there exists a feature space that achieves Pareto efficiency in True Positive Rate and True Negative Rate.
Increased Framingham Coronary Heart Disease Risk Score in Dementia Caregivers Relative to Non-Caregiving Controls

Background: Elderly individuals who provide care to a spouse suffering from dementia bear an increased risk of coronary heart disease (CHD). Objective: To test the hypothesis that the Framingham CHD Risk Score would be higher in dementia caregivers relative to non-caregiving controls. Methods: We investigated 64 caregivers providing in-home care for their spouse with Alzheimer’s disease and 41 gender-matched non-caregiving controls. All subjects (mean age 70 ± 8 years, 75% women, 93% Caucasian) had a negative history of CHD and cerebrovascular disease. The original Framingham CHD Risk Score was computed adding up categorical scores for age, blood lipids, blood pressure, diabetes, and smoking with adjustment made for sex. Results: The average CHD risk score was higher in caregivers than in controls even when co-varying for socioeconomic status, health habits, medication, and psychological distress (8.0 ± 2.9 vs. 6.3 ± 3.0 points, p = 0.013). The difference showed a medium effect size (Cohen’s d = 0.57). A relatively higher blood pressure in caregivers than in controls made the greatest contribution to this difference. The probability (area under the receiver operator curve) that a randomly selected caregiver had a greater CHD risk score than a randomly selected non-caregiver was 65.5%. Conclusions: Based on the Framingham CHD Risk Score, the potential to develop overt CHD in the following 10 years was predicted to be greater in dementia caregivers than in non-caregiving controls. The magnitude of the difference in the CHD risk between caregivers and controls appears to be clinically relevant. Clinicians may want to monitor caregiving status as a routine part of standard evaluation of their elderly patients’ cardiovascular risk.
Reopening an Abandoned Underground Mine - 3D Digital Mine Inventory Model from Historical Data and Rapid Laser Scanning

The decision to reopen a mine abandoned for 30 years is going to be complex because a significant financial commitment is going to depend on a reevaluation of both the remaining mineral resource and the surviving mine infrastructure. Historical pre-digital records will need to be assessed and new data acquired both to prove up an ore reserve and to assess the status of existing mine development and infrastructure. We describe how historic mining data were collected and compiled on the mine infrastructure (tunnels, buildings) and how mineral resource data were prepared and transferred into a 3D digital mine inventory for the Otanmaki Mine in Finland. We also demonstrate the applicability of rapid handheld laser scanning for simultaneous localization and mapping to supplement the available mine plans. Point-cloud laser scans were collected in the hoisting tower and evacuation shelter.
Gaze Holding in Healthy Subjects

Eccentric gaze in darkness evokes minor centripetal eye drifts in healthy subjects, as cerebellar control sufficiently compensates for the inherent deficiencies of the brainstem gaze-holding network. This behavior is commonly described using a leaky integrator model, which assumes that eye velocity grows linearly with gaze eccentricity. Results from previous studies in patients and healthy subjects suggest caution when this assumption is applied to eye eccentricities larger than 20 degrees. To obtain a detailed characterization of the centripetal gaze-evoked drift, we recorded horizontal eye position in 20 healthy subjects. With their head fixed, they were asked to fixate a flashing dot (50 ms every 2 s)that was quasi-stationary displacing(0.5 deg/s) between ±40 deg horizontally in otherwise complete darkness. Drift velocity was weak at all angles tested. Linearity was assessed by dividing the range of gaze eccentricity in four bins of 20 deg each, and comparing the slopes of a linear function fitted to the horizontal velocity in each bin. The slopes of single subjects for gaze eccentricities of ±0−20 deg were, in median,0.41 times the slopes obtained for gaze eccentricities of ±20−40 deg. By smoothing the individual subjects' eye velocity as a function of gaze eccentricity, we derived a population of position-velocity curves. We show that a tangent function provides a better fit to the mean of these curves when large eccentricities are considered. This implies that the quasi-linear behavior within the typical ocular motor range is the result of a tuning procedure, which is optimized in the most commonly used range of gaze. We hypothesize that the observed non-linearity at eccentric gaze results from a saturation of the input that each neuron in the integrating network receives from the others. As a consequence, gaze-holding performance declines more rapidly at large eccentricities.
Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice

Neuregulin 1 (NRG1) is a pleiotropic growth factor involved in diverse aspects of brain development and function. In schizophrenia, expression of the NRG1 type I isoform is selectively increased. However, virtually nothing is known about the roles of this isoform in brain. We have studied transgenic mice overexpressing type I NRG1 (NRG1type 1-tg) using a series of behavioural tests. NRG1type 1-tg mice have a tremor, are impaired on the accelerating rotarod, and have reduced prepulse inhibition in the context of an increased baseline startle response. There is no overall anxiety or activity phenotype, although female NRG1type 1-tg mice show mild increases in anxiety on some measures. The pattern of results shows both similarities and differences to those reported in hypomorphic NRG1 mice, and may be relevant for interpreting the increased NRG1 type I expression observed in schizophrenia.
Involvement of the Carboxyl-Terminal Region of the Yeast Peroxisomal Half ABC Transporter Pxa2p in Its Interaction with Pxa1p and in Transporter Function

Background The peroxisome is a single membrane-bound organelle in eukaryotic cells involved in lipid metabolism, including β-oxidation of fatty acids. The human genetic disorder X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene (encoding ALDP, a peroxisomal half ATP-binding cassette [ABC] transporter). This disease is characterized by defective peroxisomal β-oxidation and a large accumulation of very long-chain fatty acids in brain white matter, adrenal cortex, and testis. ALDP forms a homodimer proposed to be the functional transporter, whereas the peroxisomal transporter in yeast is a heterodimer comprising two half ABC transporters, Pxa1p and Pxa2p, both orthologs of human ALDP. While the carboxyl-terminal domain of ALDP is engaged in dimerization, it remains unknown whether the same region is involved in the interaction between Pxa1p and Pxa2p. Methods/Principal Findings Using a yeast two-hybrid assay, we found that the carboxyl-terminal region (CT) of Pxa2p, but not of Pxa1p, is required for their interaction. Further analysis indicated that the central part of the CT (designated CT2) of Pxa2p was indispensable for its interaction with the carboxyl terminally truncated Pxa1_NBD. An interaction between the CT of Pxa2p and Pxa1_NBD was not detected, but could be identified in the presence of Pxa2_NBD-CT1. A single mutation of two conserved residues (aligned with X-ALD-associated mutations at the same positions in ALDP) in the CT2 of the Pxa2_NBD-CT protein impaired its interaction with Pxa1_NBD or Pxa1_NBD-CT, resulting in a mutant protein that exhibited a proteinase K digestion profile different from that of the wild-type protein. Functional analysis of these mutant proteins on oleate plates indicated that they were defective in transporter function. Conclusions/Significance The CT of Pxa2p is involved in its interaction with Pxa1p and in transporter function. This concept may be applied to human ALDP studies, helping to establish the pathological mechanism for CT-related X-ALD disease.
Norm-induced Cuts: Optimization with Lipschitzian Black-box Functions

In this paper, we consider a finite dimensional optimization problem minimizing a continuous objective on a compact domain subject to a multi-dimensional constraint function. For the latter, we only assume the availability of a Lipschitz property. In recent literature methods based on non-convex outer approximation are proposed for tackling one dimensional equality constraints on bounded polyhedral domains, which are Lipschitz with respect to the maximum norm. To the best of our knowledge, however, there exists no non-convex outer approximation method for a general problem class. We introduce a meta-level solution framework to solve such problems and tackle the underlying theoretical foundations. Considering the feasible domain without the constraint function as manageable, our method relaxes the multidimensional constraint and iteratively refines the feasible region by means of norm-induced cuts, relying on an oracle for the resulting sub-problems. We show the method's correctness and investigate the problem complexity. In order to account for discussions about functionality, limits, and extensions, we present computational examples including illustrations.
Low micromolar Ba2+ potentiates glutamate transporter current in hippocampal astrocytes

Glutamate uptake, mediated by electrogenic glutamate transporters largely localized in astrocytes, is responsible for the clearance of glutamate released during excitatory synaptic transmission. Glutamate uptake also determines the availability of glutamate for extrasynaptic glutamate receptors. The efficiency of glutamate uptake is commonly estimated from the amplitude of transporter current recorded in astrocytes. We recorded currents in voltage-clamped hippocampal CA1 stratum radiatum astrocytes in rat hippocampal slices induced by electrical stimulation of the Schaffer collaterals. A Ba2+-sensitive K+ current mediated by inward rectifying potassium channels (Kir) accompanied the transporter current. Surprisingly, Ba2+ not only suppressed the K+ current and changed holding current (presumably, mediated by Kir) but also increased the transporter current at lower concentrations. However, Ba2+ did not significantly increase the uptake of aspartate in cultured astrocytes, suggesting that increase in the amplitude of the transporter current does not always reflect changes in glutamate uptake.
Short-Term Pain, Long-Term Gain? The Effects of IMF Economic Reform Programs on Public Health Performance†

type="main"> In this study, we evaluate the effects of the International Monetary Fund's structural adjustment programs (SAPs) on the public health performance of countries. We test the claim made by proponents of SAPs that although these programs may produce short-term hardship for the countries adopting them, they will generate positive developmental effects in the long term. Our study draws on a global data set and employs a model that takes into account the potential for selection bias in the adoption of SAPs by states. The central finding of the article is that SAPs in the short term raise the exposure of populations to conditions that increase incidences of disability and death. Contrary to the assertions made by the advocates of SAPs, we also find evidence that these programs have attenuated but still harmful effect on public health performance in the long term. This study highlights the negative influences of SAPs on public health and suggests that a need exists to reevaluate the claims that have been made regarding the developmental effects of these programs.
Building secure embedded kernels with the Think architecture.

We present in this paper the security features of Think, an object-oriented architecture dedicated to build customized operating system kernels. The Think architecture is composed of an object-oriented software framework including a trader, and a library of system abstractions programmed as components. We show how to use this architecture to build secure and eﬃcient kernels for embedded systems. Policy- neutral security is achieved by providing elementary tools that can be used by the system programmer to build a system resistant to denial of service attacks and incorporating data access control. An example of such a secure system is given by detailing how to ensure component isolation with a elementary software-based memory isolation tool.
Economic evaluation of strategies for managing crying and sleeping problems

AIMS To estimate the financial cost to the NHS of infant crying and sleeping problems in the first 12 weeks of age and to assess the cost effectiveness of behavioural and educational interventions aimed at reducing infant crying and sleeping problems relative to usual services. METHODS A cost burden analysis and cost effectiveness analysis were conducted using data from the Crying Or Sleeping Infants (COSI) Study, a three armed prospective randomised controlled trial that randomly allocated 610 mothers to a behavioural intervention (n = 205), an educational intervention (n = 202), or existing services (control, n = 203). Main outcome measures were annual total cost to the NHS of infant crying and sleeping problems in the first 12 weeks, and incremental cost per interruption free night gained for behavioural and educational interventions relative to control. RESULTS The annual total cost to the NHS of infant crying and sleeping problems in the first 12 weeks was £65 million (US$104 million). Incremental costs per interruption free night gained for the behavioural intervention relative to control were £0.56 (US$0.92). For the educational intervention relative to control they were £4.13 (US$6.80). CONCLUSIONS The annual total cost to the NHS of infant crying and sleeping problems is substantial. In the cost effectiveness analysis, the behavioural intervention incurred a small additional cost and produced a small significant benefit at 11 and 12 weeks of age. The educational intervention incurred a small additional cost without producing a significant benefit.
A Computerized Information System for Pathology

This paper describes a Computerized Information System for Pathology (CISP) capable of storing, retrieving and correlating essential information in pathology reports. Reports are entered in text form using established diagnostic terms recognizable in the system’s dictionary. Although some pre-editing of the report may be necessary, the comprehensive dictionary minimizes this effort. Dictionaries provide the vocabulary for a language which enables an economic storage of essential information in a compact and easily retrievable form. Reports and dictionaries stored on disk form the system’s data base. CISP consists of a set of modules shared by a, number of specific load module programs which store reports, retrieve them, and process requests. The system was programmed in PL/I on the IBM 360/75 OS computer system. CISP is operated from terminals situated in hospitals.
An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants

To better understand the signaling pathways which lead to DNA synthesis in mammalian cells, we have studied the transcriptional activation of genes needed during the S phase of the cell cycle. Transcription of the gene encoding a pyrimidine biosynthetic enzyme, carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase (cad), increases at the G1/S-phase boundary. We have mapped the growth-dependent response element in the hamster cad gene to the extended palindromic E-box sequence, CCACGTGG, which is centered at +65 in the 5' untranslated sequence. Mutation of the E box abolished growth-dependent transcription, and an oligonucleotide corresponding to the cad sequence at +55 to +75 (+55/+75) restored growth-dependent regulation to nonresponsive cad promoter mutants when placed down-stream of the transcription start site. The same oligonucleotide conferred less G1/S-phase induction when placed upstream of basal promoter elements. An analogous oligonucleotide containing the mutant E box had no effect in either location. Nuclear proteins bound the cad +55/+75 element in a cell cycle-dependent manner in electromobility shift assays; antibodies specific to USF and Max blocked the DNA-binding activity of different growth-regulated protein-DNA complexes. Expression of c-Myc mutants which have been shown to dominantly interfere with the function of c-Myc and Max significantly inhibited cad transcription during S phase but had no effect on transcription from another G1/S-phase-activated promoter, dhfr. These data support a model whereby E-box-binding proteins activate serum-induced transcription from the cad promoter at the G1/S-phase boundary and suggest that a Max-associated protein complex contributes to the serum response.
An achievability scheme for downlink multicell processing with finite backhaul capacity: The general case

In the general scenario of downlink multicell processing, we propose an achievability scheme for the case where the capacity of the backhaul links are limited. The achievability scheme proposed generalizes our earlier work of 2 base stations and 2 mobile users to an arbitrary number of base stations and users. Through numerical results, we demonstrate through example that in the medium range of finite backhaul capacity, our scheme outperforms other known achievability schemes.
Affect, Cognition and Change: Re-Modelling Depressive Thought

Part 1: The Problem, Some Evidence, Previous Answers. Negative Thinking and Depression. Effects of Depressed Mood on the Accessibility of Autobiographical Memories. Bower's Associative Network Theory of Mood and Memory and its Applications to Depression. Evaluating the Associative Network Model of Mood Memory. Part 2: The Interacting Cognitive Subsystems ICS Approach. The ICS Framework. Two Levels of Meaning and their Interaction. ICS and Emotion. Part 3: ICS and Mood-Congruous Cognition in the Laboratory. ICS, Mood and Memory. ICS and Mood-congruous Memory. Mood Effects on Evaluative Judgement. Part 4: Negative Thinking and the Maintenance of Depression. The ICS Account. Negative Thought Production and the Maintenance of Depression - The Evidence. ICS and Self-regulatory, Motivational Models of Depression. Part 5: ICS, Depression and Psychological Treatment. ICS and Beck's Cognitive Theory of Depression. Psychological Treatment for Depression - the ICS Perspective. Part 6: Afterword. Applicable Theory - A Puzzle in Three Dimensions.
On the Distribution of Bugs in the Eclipse System

The distribution of bugs in software systems has been shown to satisfy the Pareto principle, and typically shows a power-law tail when analyzed as a rank-frequency plot. In a recent paper, Zhang showed that the Weibull cumulative distribution is a very good fit for the Alberg diagram of bugs built with experimental data. In this paper, we further discuss the subject from a statistical perspective, using as case studies five versions of Eclipse, to show how log-normal, Double-Pareto, and Yule-Simon distributions may fit the bug distribution at least as well as the Weibull distribution. In particular, we show how some of these alternative distributions provide both a superior fit to empirical data and a theoretical motivation to be used for modeling the bug generation process. While our results have been obtained on Eclipse, we believe that these models, in particular the Yule-Simon one, can generalize to other software systems.
Individual differences in third-party interventions: How justice sensitivity shapes altruistic punishment

Altruistic punishment refers to the phenomenon that humans invest their own resources to redress norm violations without self-interest involved. We address the question of who will intervene in situations that allow for altruistic punishment. We suggest that individual differences in a genuine concern for justice, as reflected by the personality trait of justice sensitivity, determine the experience of moral emotions in the face of injustice, which in turn trigger altruistic punishment. Results of two studies support the proposed mediation effect for other-regarding justice sensitivity, even though an opportunity for compensation of the victim (Study 2) was offered as an alternative to punishment (Study 1). Furthermore, the mediation effect was observed when moral outrage was measured by means of quantified open statements (Study 1) and self-report scales using discrete emotions (Study 2). The findings help to explain the psychological mechanisms underlying engagement in costly social sanctioning of norm violations.
The effect of almonds on anthropometric measurements and lipid profile in overweight and obese females in a weight reduction program: A randomized controlled clinical trial

Background: Due to the wholesome benefits of nuts increased consumption of them has been recommended. However, because of nut's high energy density, the role of them in the treatment of overweight and obesity is vague. This current clinical trial study aims to investigate the effects of a balanced hypocaloric almond-enriched diet (AED) (almond group) in comparison to a balanced hypocaloric nut-free diet (NFD) (nut-free group) on body weight and cardiovascular disease risk factors in women with body mass index (BMI) >25 for 3-month. Materials and Methods: A total of 108 overweight and obese women were assigned in our 3-month randomized controlled trial. The subjects were randomly divided into two groups regarding a balanced hypocaloric diet with or without almond. The planned reduced calorie diets for both groups were identical except for the almond group who consumed 50 g of almonds daily. Anthropometric and laboratory measurements of the participants who completed the study were made prior to and at the end of the study. Results: A total of 100 subjects completed the study. Weight, BMI, waist circumference, waist to hip circumference ratio, total cholesterol, and triglyceride, total: High density lipoprotein-cholesterol (HDL-C), fasting blood sugar and diastolic blood pressure decreased significantly in the almond group compared to the nut-free group (P > 0.001). Greater reduction in low density lipoprotein-cholesterol (P > 0.002) and systolic blood pressure (P > 0.001) and greater increase in HDL-C (P = 0.001) were found in the nut-free group. Conclusion: The balanced hypocaloric AED in comparison to the balanced hypocaloric NFD led to a greater weight-loss and overall better improvements in studied cardiovascular disease risk factors.