Miracle-dz/UniFAR-FTUs huggingface dataset:
Multicomponent origin of cytomegalovirus lytic-phase DNA replication

Cytomegalovirus (CMV) lytic-phase DNA replication requires both trans-acting factors, such as the virus-coded DNA polymerase, and a previously undefined cis-acting element, the origin, within which initiation occurs. We have located a candidate origin of CMV lytic-phase DNA replication, oriLyt, in both simian and human strains by assessing the ability of cloned restriction fragments to mediate phosphonoformic acid-sensitive DNA replication after transfection into human fibroblasts when required trans-acting factors were supplied by infection. In initial experiments the simian CMV-like strain Colburn EcoRI D fragment directed DNA replication; this fragment contains all of the single-stranded DNA-binding protein gene (dbp) and about 7 kbp of upstream sequence. A larger region upstream of human CMV dbp also mediated replication in transient assays. Subsequent subcloning and deletion analyses defined a CMV strain Colburn region sufficient for origin function, spanning about 1,300 bp in the apparently noncoding region upstream of dbp. The nucleotide sequence of this region revealed four distinct domains, containing (i) a 9-bp repeated sequence, (ii) an A+T-rich segment, (iii) an 11-bp direct repeat, and (iv) a 47-bp direct repeat. At least some part of each of these domains was required for origin function. Therefore, like the Epstein-Barr virus lytic-phase origin of DNA replication, CMV oriLyt appears to be structurally complex.
Older adults, interface experience and cognitive decline

This paper describes an experiment undertaken to investigate intuitive interaction, particularly in older adults. Previous work has shown that intuitive interaction relies on past experience, and has also suggested that older people demonstrate less intuitive uses and slower times when completing set tasks with various devices. Similarly, this experiment showed that past experience with relevant products allowed people to use the interfaces of two different microwaves more quickly and intuitively. It also revealed that certain aspects of cognitive decline related to aging, such as central executive function, have more impact on time, correct uses and intuitive uses than chronological age. Implications of these results are discussed.
Convergence between SVM-based and distance-based paradigms for speaker recognition

This paper investigates the convergence between SVM-based and distance-based classiﬁers in speaker recognition. It focuses on approaches in speaker recognition where a speech utterance is represented with a ﬁxed dimension vector. We study various preprocessings to apply on the vectors before classiﬁcation, and various choices of negative samples to train SVM. We prove that in one speciﬁc conﬁguration, the SVM-based classi-ﬁer and the distance-based classiﬁer are strictly equivalent. Experiments on NIST2006 database, within the Anchor Models framework, show that this speciﬁc conﬁguration gets very good performance.
Repeat Radiosurgery for Trigeminal Neuralgia.

BACKGROUND Repeat Gamma Knife radiosurgery (GKRS) is an established option for patients whose pain has recurred after the initial procedure, with reported success rates varying from 68% to 95%. Predictive factors for response to the repeat GKRS are ill-defined. OBJECTIVE This cohort study aimed to report the outcomes and factors predictive of success for patients who have undergone repeated GKRS for trigeminal neuralgia at Wake Forest University Baptist Medical Center. METHODS Between 1999 and 2013, 152 patients underwent repeat GKRS at Wake Forest, 125 of whom were available for long-term follow-up. A retrospective chart review and telephone interviews were conducted to determine background medical history, dosimetric data, outcomes, and adverse effects of the procedure. RESULTS Eighty-four percent of patients achieved at least Barrow Neurological Institute (BNI) IIIb pain relief, with 46% achieving BNI I. The 1-, 3-, and 5-year rates of BNI I pain relief were 63%, 50%, and 37%, respectively. The 1-, 3-, and 5-year rates of BNI IIIb or better pain relief were 74%, 59%, and 46%, respectively. One patient experienced bothersome numbness and 2 patients developed anesthesia dolorosa. The dominant predictive factors for pain relief were facial numbness after the first GKRS and a positive pain response to the first GKRS. CONCLUSION Repeat GKRS is an effective method of treating recurrent trigeminal neuralgia. Patients who have facial numbness after the first treatment and a positive pain response to the first GKRS are significantly more likely to respond well to the second treatment.
Relapsing Fever–Like Spirochetes Infecting European Vector Tick of Lyme Disease Agent

To determine whether relapsing fever–like spirochetes associated with hard ticks may infect Ixodes ricinus ticks in central Europe, we screened questing ticks for 16S rDNA similar to that of Asian and American relapsing fever–like spirochetes. We compared the prevalence of these spirochetes to that of Lyme disease spirochetes transmitted by the same vector. Relapsing fever-like spirochetes infect 3.5% of questing vector ticks in our three central European sites near the Rhein Valley. These spirochetes differ genetically from their American and Asian analogs while being relatively homogeneous in the region we sampled. The Lyme disease genospecies most commonly detected in central Europe are distributed broadly, whereas those that are less frequently found appear to be place-specific. The absence of co-infected ticks suggests that relapsing fever–like and Lyme disease spirochetes may not share hosts. Exposure risk for relapsing fever–like spirochetes is similar to that of certain Lyme disease genospecies. Although many persons may be bitten by ticks infected by relapsing fever–like spirochetes, health implications remain unknown.
The pentachlorophenol-dehalogenating Desulfitobacterium hafniense strain PCP-1

In this report, a complete description of Desulfitobacterium hafniense strain PCP-1 is presented. The D. hafniense strain PCP-1 was isolated from a methanogenic consortium for its capacity to dehalogenate pentachlorophenol (PCP) into 3-chlorophenol. This strain is also capable of dehalogenating several other chloroaromatic compounds and tetrachloroethene into trichloroethene. Four gene loci encoding putative chlorophenol-reductive dehalogenases (CprA2 to CprA5) were detected, and the products of two of these loci have been demonstrated to dechlorinate different chlorinated phenols. Strain PCP-1 was used in laboratory-scale bioprocesses to degrade PCP present in contaminated environments. Desulfitobacterium hafniense PCP-1 is an excellent candidate for the development of efficient bioprocesses to degrade organohalide compounds.
Ecologies of Inscription: Technologies of Making the Social Organization of Work and the Mass Production of Machine Parts Visible in Collaborative Activity

This article focuses on technologies for making social organization, work, and mass production mutually visible in collaborative activity. I describe how practitioners in a manufacturing factory mutually organize accountability of their own social organization, the work, and the mass-produced products through using various inscriptions and other technologies along with concretely demonstrating these presuppositions of society and work. Among them, I focus on how multilayered accountabilities are organized and on how the multilayered accountabilities or multiply-organized activities are linked up and coordinated with inscriptions and other technologies. At linking points, mutualities of various divisions of labor are organized. In addition, at a linking point, what occurs is not the transmission of invariant information, but the transformation of the information. Imaging the relations across inscriptions as a linear chain can be viewed as one of the more popular inscriptions locally utilized by management on specific occasions.
How Global Is the Global Biodiversity Information Facility?

There is a concerted global effort to digitize biodiversity occurrence data from herbarium and museum collections that together offer an unparalleled archive of life on Earth over the past few centuries. The Global Biodiversity Information Facility provides the largest single gateway to these data. Since 2004 it has provided a single point of access to specimen data from databases of biological surveys and collections. Biologists now have rapid access to more than 120 million observations, for use in many biological analyses. We investigate the quality and coverage of data digitally available, from the perspective of a biologist seeking distribution data for spatial analysis on a global scale. We present an example of automatic verification of geographic data using distributions from the International Legume Database and Information Service to test empirically, issues of geographic coverage and accuracy. There are over 1/2 million records covering 31% of all Legume species, and 84% of these records pass geographic validation. These data are not yet a global biodiversity resource for all species, or all countries. A user will encounter many biases and gaps in these data which should be understood before data are used or analyzed. The data are notably deficient in many of the world's biodiversity hotspots. The deficiencies in data coverage can be resolved by an increased application of resources to digitize and publish data throughout these most diverse regions. But in the push to provide ever more data online, we should not forget that consistent data quality is of paramount importance if the data are to be useful in capturing a meaningful picture of life on Earth.
Preschool teachers’ approaches to science: a comparison of a Chinese and a Norwegian kindergarten

This comparative study examines the way in which preschool teachers support children's science learning in a Chinese and a Norwegian kindergarten. The study takes an ethnographic approach. Preschool teachers from one kindergarten in Shanghai and one in Bergen were asked to videotape educational activities that focused on science in their kindergartens. These videos, as well as videos taken by the researchers, were used as a starting point for semi-structured group interviews with the preschool teachers. Our aim was to explore the science-oriented activities, strategies and objectives; and some of the sociocultural factors that might influence the preschool teachers’ practices. Closer analysis, which took into consideration cultural values and traditions, revealed clear links between culture and practice.
The Value of Zoo Experiences for Connecting People with Nature

ABSTRACT Zoos aspire to bring people closer to nature through visitor education and by creating environments that immerse visitors into naturalistic surroundings. Yet to date, the psychological and behavioral consequences of these attempts have not been well-documented through empirical study. The present study was designed to determine if visiting a zoo had a measurable impact on visitors' relationships with nature and to test whether this effect was moderated by the zoo setting and/or type of zoo experience. Data were collected from three different types of zoos in New York City. A total of 242 zoo visitors participated in this study by completing a set of scales measuring explicit and implicit self-nature associations. Findings suggest that zoo experiences do promote an increased implicit connectedness with nature, but no changes were found for self-reported explicit connectedness with nature. The authors found no evidence that this effect was moderated by a specific design strategy or scale of institution.
A mobility management scheme based routing for hierarchical ad hoc networks

In recent years, many routing protocols and mobility management methods for hierarchical mobile ad hoc networks have been proposed, however few schemes are aimed to improve the routing performance under high node mobility. This paper presents a mobility management algorithm built upon HOLSR (Hierarchical Optimum Link State Routing) [1] routing protocol. Besides default route, temporary route between mobile node and cluster head is established to provide sustained communication. Simulation experiments are conducted, and the results show the effectiveness of the proposed scheme.
IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels

The central nervous system architecture is markedly modified by sensory experience during early life, but a decline of plasticity occurs with age. Recent studies have challenged this dogma providing evidence that both pharmacological treatments and paradigms based on the manipulation of environmental stimulation levels can be successfully employed as strategies for enhancing plasticity in the adult nervous system. Insulin-like growth factor 1 (IGF-1) is a peptide implicated in prenatal and postnatal phases of brain development such as neurogenesis, neuronal differentiation, synaptogenesis, and experience-dependent plasticity. Here, using the visual system as a paradigmatic model, we report that IGF-1 reactivates neural plasticity in the adult brain. Exogenous administration of IGF-1 in the adult visual cortex, indeed, restores the susceptibility of cortical neurons to monocular deprivation and promotes the recovery of normal visual functions in adult amblyopic animals. These effects were accompanied by a marked reduction of intracortical GABA levels. Moreover, we show that a transitory increase of IGF-1 expression is associated to the plasticity reinstatement induced by environmental enrichment (EE) and that blocking IGF-1 action by means of the IGF-1 receptor antagonist JB1 prevents EE effects on plasticity processes.
COMPARATIVE NEUROPHYSIOLOGICAL STUDY FOR THE DIAGNOSIS OF MILD POLYNEUROPATHY IN PATIENTS WITH DIABETES MELLITUS AND GLUCOSE INTOLERANCE

This article evaluates diagnostic sensitivity of minimal F-wave latency, sural/radial amplitude ratio (SRAR), dorsal sural/radial amplitude ratio (DSRAR), sympathetic skin response (SSR), and R-R interval variability (RRIV) for detecting early polyneuropathy in patients with glucose intolerance and diabetic patients. F-wave latencies were more prolonged in diabetic patients with normal and abnormal nerve conduction studies than control subjects (p < .001). SRAR was lower, SSR latency was more prolonged, and RRIV was lower in diabetic patients with abnormal nerve conduction studies than healty controls (p < .001). SSR latency was more prolonged and RRIV was lower in diabetic patients with normal nerve conduction studies than healty controls (p < .01, p < .05, respectively). DSRAR was lower in diabetic patients with normal and abnormal nerve conduction studies than control subjects (p < .001). DSRAR was also lower in patients with glucose intolerance than control subjects (p < .01). DSRAR was the most sensitive and specific test in either of diabetic patients with normal nerve conduction studies (sensitivity 66%, specificity 90%) and diabetic patients with abnormal nerve conduction studies (sensitivity 100%, specificity 90%). DSRAR is the most reliable method for detection of early nerve pathology. Patients with glucose intolerance might have subclinical neuropathy that can be demonstrated with DSRAR analysis.
On reducing classifier granularity in mining concept-drifting data streams

Many applications use classification models on streaming data to detect actionable alerts. Due to concept drifts in the underlying data, how to maintain a model's up-to-dateness has become one of the most challenging tasks in mining data streams. State of the art approaches, including both the incrementally updated classifiers and the ensemble classifiers, have proved that model update is a very costly process. In this paper, we introduce the concept of model granularity. We show that reducing model granularity will reduce model update cost. Indeed, models of fine granularity enable us to efficiently pinpoint local components in the model that are affected by the concept drift. It also enables us to derive new components that can easily integrate with the model to reflect the current data distribution, thus avoiding expensive updates on a global scale. Experiments on real and synthetic data show that our approach is able to maintain good prediction accuracy at a fraction of model updating cost of state of the art approaches.
Effects of Right Parietal Transcranial Magnetic Stimulation on Object Identification and Orientation Judgments

We investigated the role played by the right parietal lobe in object identification and the ability to interpret object orientation, using transcranial magnetic stimulation (TMS) to momentarily interfere with ongoing cortical activity. Short trains of TMS pulses (12 Hz) were applied to a site overlying the right intraparietal sulcus/inferior parietal lobe while subjects performed either object identification tasks (i.e., picture-word verification and categorizing objects as natural or manufactured) or object orientation judgment tasks (i.e., picture-arrow verification and deciding whether an object was rotated clockwise or counterclockwise). Across different tasks, right parietal TMS impaired orientation judgments, but facilitated object identification, compared to TMS applied to a brain vertex control site. These complementary findings demonstrate that the right parietal lobea region belonging to the dorsal visual streamis critical for processing the spatial attributes of objects, but not their identity. The observed improvement in object recognition, however, suggests an indirect role for the right parietal lobe in object recognition. We propose that this involves the creation of a spatial reference frame for the object, which allows interaction with the object and the individuation of specific viewing instances.
Efficient PAC Learning from the Crowd

In recent years crowdsourcing has become the method of choice for gathering labeled training data for learning algorithms. Standard approaches to crowdsourcing view the process of acquiring labeled data separately from the process of learning a classiﬁer from the gathered data. This can give rise to computational and statistical challenges. For example, in most cases there are no known computationally efﬁcient learning algorithms that are robust to the high level of noise that exists in crowdsourced data, and efforts to eliminate noise through voting often require a large number of queries per example. In this paper, we show how by interleaving the process of labeling and learning, we can attain computational efﬁciency with much less overhead in the labeling cost. In particular, we consider the realizable setting where there exists a true target function in F and consider a pool of labelers. When a noticeable fraction of the labelers are perfect, and the rest behave arbitrarily, we show that any F that can be efﬁciently learned in the traditional realizable PAC model can be learned in a computationally efﬁcient manner by querying the crowd, despite high amounts of noise in the responses. Moreover, we show that this can be done while each labeler only labels a constant number of examples and the number of labels requested per example, on average, is a constant. When no perfect labelers exist, a related task is to ﬁnd a set of the labelers which are good but not perfect. We show that we can identify all good labelers, when at least the majority of labelers are good.
Examination of the paths between personality, current mood, its evaluation, and emotion regulation

In an ongoing longitudinal study, a Big Five Personality Inventory was completed by 122 men and 126 women at age 33. At age 36, the Brief Mood Introspection Scale, the Meta‐Evaluation Scale, and the Meta‐Regulation Scale were administered to 140 men and 127 women. The results, based on path analyses, lent support to a hypothesized model, according to which current mood (Negative, Positive, Active, Calm) and mood evaluation (Mood Influence, Typicality and Acceptance, Clarity) mediate the relationship between the Big Five personality traits and emotion regulation strategies (Repair, Dampening, Maintenance). For both sexes, Neuroticism was the most significant trait in terms of emotion regulation. A sex difference emerged: in general, personality traits and mood variables explained emotion regulation more significantly in men. Copyright © 2001 John Wiley & Sons, Ltd.
Improving Sales Performance through Commitment to Superior Customer Value: The Role of Psychological Ethical Climate

Given the potential importance of ethics in shaping business relationships, this paper explores the impact of salespeople’s psychological ethical climate on their commitment to providing superior customer value, and its ensuing affect on salesperson performance. The results suggest that ethical climate negatively affects ethical ambiguity and salespeople’s commitment to providing superior customer value, while ethical ambiguity negatively affects commitment to providing superior customer value. Salespeople who are committed to providing superior customer value report greater sales performance. Based on these findings, both theoretical and managerial implications are provided.
Thermal dose fractionation affects tumour physiological response

Purpose: It is unknown whether a thermal dose should be administered using a few large fractions with higher temperatures or a larger number of fractions with lower temperatures. To evaluate this we assessed the effect of administering the same total thermal dose, approximately 30 CEM43T90, in one versus three to four fractions per week, over 5 weeks. Materials and methods: Canine sarcomas were randomised to receive one of the hyperthermia fractionation schemes along with fractionated radiotherapy. Tumour response was based on changes in tumour volume, oxygenation, water diffusion quantified using MRI, and a panel of histological and immunohistochemical end points. Results: There was a greater reduction in tumour volume and water diffusion at the end of therapy in tumours receiving one hyperthermia fraction per week. There was a weak but significant association between improved tumour oxygenation 24 h after the first hyperthermia treatment and extent of volume reduction at the end of therapy. Finally, the direction of change of HIF-1α and CA-IX immunoreactivity after the first hyperthermia fraction was similar and there was an inverse relationship between temperature and the direction of change of CA-IX. There were no significant changes in interstitial fluid pressure, VEGF, vWF, apoptosis or necrosis as a function of treatment group or temperature. Conclusions: We did not identify an advantage to a three to four per week hyperthermia prescription, and response data pointed to a one per week prescription being superior.
Exceptions to the Rule: Exceptional Health Among the Disadvantaged

Countless studies show that socioeconomic status (SES) is strongly related to morbidity and mortality. However, few studies consider the substantial variability in health within socioeconomic strata. In this article, the authors examine the incompatibility between stratification-based theories of health inequality and empirical patterns of exceptional health among the socially disadvantaged. Using panel data from the Health and Retirement Survey (1992-2008), the authors test the mediating and moderating effects of various predictors of exceptional health (no chronic diseases or physical limitations) for middle-aged and older adults with and without a high school education. Results suggest that a combination of demographic characteristics, family and religious factors, socioeconomic resources, health behaviors, psychological makeup, and biological attributes play differing roles in protecting the health of disadvantaged men and women. The findings underscore the complex associations among SES, protective mechanisms, and health and offer new insight into how disadvantaged adults defy their odds of poor health.