Miracle-dz/UniFAR-FTUs huggingface dataset:
The Design of Acoustic Horns for Ultrasonic Aided Tube Double Side Flange Making

Encapsulated O-rings are specifically designed to address the problem of sealing the most hostile chemicals and extreme temperature applications. Ultrasonic vibration hot embossing and ultrasonic welding techniques provide a fast and reliable method to fabricate encapsulated O-ring. This paper performs the design and analysis method of the acoustic horns with double extrusion to process tube double side flange simultaneously. The paper deals with study through Finite Element Method (FEM) of ultrasonic stepped horn used to process a capsulated O-ring, the theoretical dimensions of horns, and their natural frequencies and amplitudes are obtained through the simulations of COMOSOL software. Furthermore, real horns were fabricated, tested and verified to proof the practical utility of these horns. Keywords—Encapsulated O-rings, ultrasonic vibration hot embossing, flange making, acoustic horn, finite element analysis.
Synaptic Control of Glycine and GABAA Receptors and Gephyrin Expression in Cultured Motoneurons

We have evaluated the influence of the secretory phenotype of presynaptic boutons on the accumulation of postsynaptic glycine receptors (GlyRs), type A GABA receptors (GABAARs), and gephyrin clusters. The cellular distribution of these components was analyzed on motoneurons cultured either alone or with glycinergic and/or GABAergic neurons. In motoneurons cultured alone, we observed gephyrin clusters at nonsynaptic sites and in front of cholinergic boutons, whereas glycine and GABAA receptors formed nonsynaptic clusters. These receptors are functionally and pharmacologically similar to those found in cultures of all spinal neurons. Motoneurons receiving GABAergic innervation from dorsal root ganglia neurons displayed postsynaptic clusters of gephyrin and GABAARβ but not of GlyRα/β subunits. In motoneurons receiving glycinergic and GABAergic innervation from spinal interneurons, gephyrin, GlyRα/β, and GABAARβ formed mosaics at synaptic loci. These results indicate that (1) the transmitter phenotype of the presynaptic element determines the postsynaptic accumulation of specific receptors but not of gephyrin and (2) the postsynaptic accumulation of gephyrin alone cannot account for the formation of GlyR-rich microdomains.
Robust Channel Tracking in Fast Fading MIMO channels

Channel estimation for Alamouti space frequency coded (ASFC) 2 times 2 and 2 times 1 MIMO OFDM systems, employing decision directed channel tracking (DDCT) for high fade rates and long frame durations is studied here. Errors in the regression matrix (i.e. equalisation errors) have a Gaussian distribution, but due to error propagation problem of DDCT at high fade rates and long symbol durations, large deviations from the Gaussian model is observed. Hence the problem of channel estimation can be formulated as an outlier contaminated Gaussian linear regression problem. Most of the classical estimators like Least squares (LS) and Expectation Maximisation (EM) algorithm perform poorly in presence of outliers. Moreover, for a MIMO system the source of outliers are the erroneous decisions of any of the multiple input channels. Here, we propose to use the EM algorithm to partition multiple input channel into independent estimations for each transmit-receive antenna pair and provide an iterative framework for solving the multiple regression problem. EM algorithm is made robust using the Huber's M principle (for the E and the M steps) and it is shown analytically that mean square error (MSE) performance improves as compared to existing schemes which assume Gaussian noise. The simulated symbol error rate (SER) and MSE performances demonstrate the significant gains of the proposed robust EM algorithm over existing DDCT techniques at high normalised fade rates for the given system.
Towards an Analysis of Argumentation Structure and the Strength of Arguments in News Editorials

Editorials in general fall under persuasive texts.These types of texts intend to persuade the readers over a certain issue or topic.Hence persuasion involves the use of persuasive elements(opinion words and expressions)and facts presented in the form of arguments.A closer look at editorials reveals that they consist of an argumentation structure consisting of an opening statement(also known as the conclusion in argumentation theory[6,7,12,13,15]),which in turn is supported by other statements(known as the supports in argumentation theory)for or against the conclusion.These supports as well as the conclusion can be either facts or opinions.The underlying supports for or against a conclusion may be further developed,illustrated,justified,elaborated etc.by means of text fragments,also widely known as rhetoric relations[11]. The proposed work is aimed towards analyzing the argumentation structure and the strengths of arguments in news editorials thus determining the persuasiveness inherent in the texts.The result is a discourse analysis of opinions as stated in editorial texts producing a kind of dedicated semantic representation. Ultimately, the analyzed argumentation structure would be used to construct a synthesis of positive and negative arguments on a particular topic from one or several editorials(single or multiple sources)over a common date or a span of time.Such a synthesis can provide a relatively true view of how an event has been perceived by the public in general and is of much interest to journalists, public figures and political analysts.We also will be analyzing the change in opinions taking time as an evaluative factor for change as reported in [8,9]. In order to automate the analysis as well as the synthesis construction process,we would be developing a computational model that would suggest methods and appropriate techniques.The manually annotated texts and collected editorials would serve as training data and test data respectively for validating the computation model over ideal outputs[1]. Currently, the work is in its preliminary stage,primarily focused towards analyzing the different facets of supports and rhetorical relations required for an adequate semantic-pragmatic analysis of the underlying argumentation structures in editorials.In parallel with the analysis,we are also in the process of specifying tags for annotating editorials in order to establish patterns characteristic to the different facets of support.We noted that the opinions and the argumentation structure in editorials are not so apparent and structured,which makes synthesis construction a challenging task.
Comparison of different approaches for reconstruction of radiation patterns

In this paper, the phase retrieval method exploiting global optimization is presented. This minimization approach is based on two amplitude measurements in the near-field of the AUT. Two different approaches calculating the error function are presented and compared. The first approach is classical functional method and second one is based on the principle of Fourier iterative method. In this paper, the possibility of using amplitude from only one scanning plane for reconstruction of radiation patterns is also investigated. The comparison of the one-plane algorithm with two-plane one is also done. The all verifications are made on synthesized data of the antenna array.
An informative protocol for the investigation of recurrent miscarriage: preliminary experience of 500 consecutive cases.

A total of 500 consecutive women (mean age 32.9 years; SD 5 years) presenting with a history of recurrent miscarriages (median 4; range 3-17) were investigated for the presence of antiphospholipid antibodies (APA), polycystic ovaries (PCO), hypersecretion of luteinizing hormone (LH) and chromosome abnormalities in order to detect an underlying cause of their pregnancy losses. All women had details of their previous reproductive history, investigations and treatment documented: 76% of the women had experienced only early pregnancy losses (miscarriage < 13 weeks gestation); 32% had a history of subfertility; and significant parental chromosome rearrangements were present in 3.6% of couples. An ultrasound diagnosis of PCO was made in 56% of women, 58% of whom were demonstrated to hypersecrete LH, based on early morning urinary LH analysis. Circulating APA were found in 14% of women. An underlying cause of recurrent miscarriage--genetic, endocrine or autoimmune--was found in > 50% of couples. Women in the latter two groups are being recruited to randomized treatment trials which are discussed.
Algorithmic aspects of connectivity, allocation and design problems

To those who probably will understand the least, but matter the most. iii ACKNOWLEDGEMENTS First and foremost, I thank my advisor, Vijay Vazirani, for his constant support, advice and help throughout these five years. I hope I have imbibed an of the infinite energy with which he does research. Thanks Vijay for everything! I thank Prasad Tetali for patiently listening to me ranting about my work and always advising me on how to proceed further. I will surely miss such an ideal sounding board. I thank Robin Thomas, William Cook and Adam Kalai for being on my committee. Thanks Robin for a careful reading of a paper of mine, Prof. Cook for being a careful reader of my thesis, and Adam for the chats and the margaritas! Many thanks to all the professors in Georgia Tech for their excellent lectures, both in and out of classes. The amount I have learnt in these five years is immeasurable. I am indebted to ACO, the excellent program I was in, and the College of Computing, for the excellent facilities and support it provided me throughout my stay here. Special thanks to Dani Denton for always taking care of the paperwork, which I am horrible at. Thanks to all the excellent graduate students in theory at Georgia Tech who are more friends than colleagues. Some of them are my co-authors — Nisheeth Vishnoi, Aranyak Without them none of this would have been possible. A very special thanks to Nikhil Devanur for the endless hours we spent discussing work, life and everything under the sun. for a wonderful summer in California. Many thanks to Prof. Abhiram Ranade of IIT-Bombay, my alma-mater, for starting me off on my research career. A special thanks to Viswanath Nagarajan for being a friend and colleague since my undergraduate days. My life as a graduate student would have been a million-folds more stressful, were it not for the only Indian fraternity in Atlanta — Rama Papa Kappa. Thanks to all the members for always putting things into perspective. Words cannot describe my gratitude towards the people dearest to me — Harini, Tua, my family, my mother and my father. Their belief in me, although at times irrational, has been vital for this work. I dedicate this thesis to them. SUMMARY Most combinatorial optimization problems are NP-hard, which implies that under well-believed complexity assumptions, there exist no polynomial time algorithms …
FansyRoute: adaptive fan-out for variably intermittent challenged networks

We consider the problem of routing in a highly and variably intermittent wireless network to support delay-intolerant as well as delay tolerant applications. Specifically, the links in such a network are too volatile to maintain a consistent topology, rendering most MANET protocols ineffective. At the same time, store-and-forward (DTN) techniques are not an option due to the need for delay intolerance, and may be unnecessary due to the likely availability of contemporaneous, albeit rapidly changing, paths. We present a novel routing mechanism called FansyRoute, aimed at this challenged region between MANETs and DTNs. FansyRoute adaptively adjusts the number of replications (fan-out) on a per-node basis, taking into account the level of intermittency along the path to the destination and a user-specified tradeoff between delivery expectation and the cost of replication. We study the performance of two FansyRoute schemes on a prime example of such variably intermittently connected networks, namely asynchronously duty-cycled sensor networks. Using ns-3, we compare FansyRoute to OLSR, AODV and Flooding. The results show that in an intermittent network, FansyRoute can deliver 50% more packets than the single path protocols, with less than 5% of the replication incurred by flooding. FansyRoute replicates only when needed and the replication is restricted to the challenged regions of the network.
Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth

In breast and certain other cancers, receptor tyrosine kinases, including the insulin-like growth factor I receptor (IGF-IR), play an important role in promoting the oncogenic process. The IGF-IR is therefore an important target for developing new anti–breast cancer therapies. An initial screening of a chemical library against the IGF-IR in breast cancer cells identified a diaryl urea compound as a potent inhibitor of IGF-IR signaling. This class of compounds has not been studied as inhibitors of the IGF-IR. We studied the effectiveness of one diaryl urea compound, PQ401, at antagonizing IGF-IR signaling and inhibiting breast cancer cell growth in culture and in vivo. PQ401 inhibited autophosphorylation of the IGF-IR in cultured human MCF-7 cells with an IC50 of 12 μmol/L and autophosphorylation of the isolated kinase domain of the IGF-IR with an IC50 <1 μmol/L. In addition, PQ401 inhibited the growth of cultured breast cancer cells in serum at 10 μmol/L. PQ401 was even more effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50, 6 μmol/L). Treatment of MCF-7 cells with PQ401 was associated with a decrease in IGF-I-mediated signaling through the Akt antiapoptotic pathway. Twenty-four hours of treatment with 15 μmol/L PQ401 induced caspase-mediated apoptosis. In vivo, treatment with PQ401 (i.p. injection thrice a week) reduced the growth rate of MCNeuA cells implanted into mice. These studies indicate that diaryl urea compounds are potential new agents to test in the treatment of breast and other IGF-I-sensitive cancers. [Mol Cancer Ther 2006;5(4):1079–86]
Satem: Trusted Service Code Execution across Transactions

Web services and service oriented architectures are becoming the de facto standard for Internet computing. A main problem faced by users of such services is how to ensure that the service code is trusted. While methods that guarantee trusted service code execution before starting a client-service transaction exist, there is no solution for extending this assurance to the entire lifetime of the transaction. This paper presents Satem, a Service-aware trusted execution monitor that guarantees the trustworthiness of the service code across a whole transaction. The Satem architecture consists of an execution monitor residing in the operating system kernel on the service provider platform, a trust evaluator on the client platform, and a service commitment protocol. During this protocol, executed before every transaction, the client requests and verifies against its local policy a commitment from the service platform that promises trusted code execution. Subsequently, the monitor enforces this commitment for the duration of the transaction. To initialize the trust on the monitor, we use the Trusted Platform Module specified by the Trusted Computing Group. We implemented Satem under the Linux 2.6. 12 kernel and tested it for a web service and DNS. The experimental results demonstrate that Satem does not incur significant overhead to the protected services and does not impact the unprotected services.
Adaptive Routing Strategies for Modern High Performance Networks

Today's scalable high-performance applications heavily depend on the bandwidth characteristics of their communication patterns. Contemporary multi-stage interconnection networks suffer from network contention which might decrease application performance. Our experiments show that the effective bisection bandwidth of a non-blocking 512-node Clos network is as low as 38% if the network is routed statically.In this paper, we propose and analyze different adaptive routing schemes for those networks. We chose Myrinet/MX to implement our proposed routing schemes. Our best adaptive routing scheme is able to increase the effective bisection bandwidth to 77% for 512 nodes and 100% for smaller node counts. Thus, we show that our proposed adaptive routing schemes are able to improve network throughput significantly.
Supporting Systematic Usage of Context in Web Applications

Context can be seen as a paradigm aiming to improve user interaction with software. For Web applications in particular, the issues of content explosion and technological constraints need to be addressed better. This paper discusses an approach for engineering contextaware, adaptive Web applications. This approach integrates context knowledge with domain ontologies, and allows adaptation to be specified for each aspect of application generation. We further describe CATWALK, our implemented framework, which makes use of the context models to enable adaptivity in applications.
Generating Network Models Using the S-Metric

The ability to create random models of real networks is useful for understanding the interactions in these systems. Several researchers have proposed modeling complex networks by using the node degree distribution, the most popular being a power-law distribution. Recent work by Li et al. introduced the S metric as a metric to characterize the structure of networks with power-law distributions. In this paper, we examine some of the practical difficulties of producing random graphs with a given degree sequence and an approximate S value. We give a solution for this problem that we have had success using in our
Throughput of TCP over Cognitive Radio Channels

We study TCP performance over ON-OFF channels, i.e., channels which are busy/unavailable for transmissions intermittently. The data may also be subject to random errors. Such situations arise in cognitive radio networks when secondary users opportunistically use the channel when the licensed user is not using it. We use a Markov model to evaluate the TCP throughput and probability of retransmission timeout when the ON-OFF periods are exponentially distributed and then extend it to phase-type ON and phase-type OFF periods. We then generalize the Markovian model to more general ON-OFF duration distributions and also to multiple TCP connections.
Multiwavelength Mode-Locked Fiber-Ring Laser Based on Reflective Semiconductor Optical Amplifiers

An active multiwavelength mode-locked fiber ring laser is demonstrated by exploiting cross-gain modulation in a reflective semiconductor optical amplifier. A length of dispersion-compensation fiber is incorporated in the ring cavity to enhance the multiwavelength performance. Simultaneous tunable triple-wavelength mode-locking is implemented with the pulse repetition of 10 GHz and wavelength spacing of 1.12 nm. The results provide an effective approach to fulfill all-optical clock recovery and data pattern conversion in multiwavelength for future optical communication systems.
Connecting Quorum Sensing, c-di-GMP, Pel Polysaccharide, and Biofilm Formation in Pseudomonas aeruginosa through Tyrosine Phosphatase TpbA (PA3885)

With the opportunistic pathogen Pseudomonas aeruginosa, quorum sensing based on homoserine lactones was found to influence biofilm formation. Here we discern a mechanism by which quorum sensing controls biofilm formation by screening 5850 transposon mutants of P. aeruginosa PA14 for altered biofilm formation. This screen identified the PA3885 mutant, which had 147-fold more biofilm than the wild-type strain. Loss of PA3885 decreased swimming, abolished swarming, and increased attachment, although this did not affect production of rhamnolipids. The PA3885 mutant also had a wrinkly colony phenotype, formed pronounced pellicles, had substantially more aggregation, and had 28-fold more exopolysaccharide production. Expression of PA3885 in trans reduced biofilm formation and abolished aggregation. Whole transcriptome analysis showed that loss of PA3885 activated expression of the pel locus, an operon that encodes for the synthesis of extracellular matrix polysaccharide. Genetic screening identified that loss of PelABDEG and the PA1120 protein (which contains a GGDEF-motif) suppressed the phenotypes of the PA3885 mutant, suggesting that the function of the PA3885 protein is to regulate 3,5-cyclic diguanylic acid (c-di-GMP) concentrations as a phosphatase since c-di-GMP enhances biofilm formation by activating PelD, and c-di-GMP inhibits swarming. Loss of PA3885 protein increased cellular c-di-GMP concentrations; hence, PA3885 protein is a negative regulator of c-di-GMP production. Purified PA3885 protein has phosphatase activity against phosphotyrosine peptides and is translocated to the periplasm. Las-mediated quorum sensing positively regulates expression of the PA3885 gene. These results show that the PA3885 protein responds to AHL signals and likely dephosphorylates PA1120, which leads to reduced c-di-GMP production. This inhibits matrix exopolysaccharide formation, which leads to reduced biofilm formation; hence, we provide a mechanism for quorum sensing control of biofilm formation through the pel locus and suggest PA3885 should be named TpbA for tyrosine phosphatase related to biofilm formation and PA1120 should be TpbB.
Adaptive and Iterative Multi-Branch MMSE Decision Feedback Detection Algorithms for Multi-Antenna Systems

In this work, decision feedback (DF) detection algorithms based on multiple processing branches for multi-input multi-output (MIMO) spatial multiplexing systems are proposed. The proposed detector employs multiple cancellation branches with receive filters that are obtained from a common matrix inverse and achieves a performance close to the maximum likelihood detector (MLD). Constrained minimum mean-squared error (MMSE) receive filters designed with constraints on the shape and magnitude of the feedback filters for the multi-branch MMSE DF (MB-MMSE-DF) receivers are presented. An adaptive implementation of the proposed MB-MMSE-DF detector is developed along with a recursive least squares-type algorithm for estimating the parameters of the receive filters when the channel is time-varying. A soft-output version of the MB-MMSE-DF detector is also proposed as a component of an iterative detection and decoding receiver structure. A computational complexity analysis shows that the MB-MMSE-DF detector does not require a significant additional complexity over the conventional MMSE-DF detector, whereas a diversity analysis discusses the diversity order achieved by the MB-MMSE-DF detector. Simulation results show that the MB-MMSE-DF detector achieves a performance superior to existing suboptimal detectors and close to the MLD, while requiring significantly lower complexity.