Miracle-dz/UniFAR-FTUs huggingface dataset:
Automated Tube Voltage Selection for Radiation Dose Reduction in CT Angiography Using Different Contrast Media Concentrations and a Constant Iodine Delivery Rate.

OBJECTIVE The purpose of this study was to systematically investigate radiation dose reduction using automated tube voltage selection during CT angiography (CTA) and to evaluate the impact of contrast medium (CM) injection protocols on dose reduction. MATERIALS AND METHODS A circulation phantom containing the thoracic and abdominal vasculature was used. Four different concentrations of CM (iopromide 300 and 370 mg I/mL and iomeprol 350 and 400 mg I/mL) were administered while maintaining an identical iodine delivery rate (1.8 g I/s) and total iodine load (20.0 g). Three different scanning protocols for CTA of the thoracoabdominal aorta were used: protocol A, no dose modulation; protocol B, automated tube current modulation (CARE Dose4D); and protocol C, automated tube voltage selection (CARE kV). The dose-length product was recorded to calculate the effective dose. Attenuation values (in Hounsfield units), image noise levels, and signal-to-noise ratios (SNRs) in six predefined intravascular sites (three thoracic and three abdominal) were measured by two readers. All values were analyzed using the Kruskal-Wallis test and two-way ANOVA. RESULTS There was a significant reduction in the effective dose (in millisieverts) for protocols B (mean ± SD, 2.03 ± 0.1 mSv) and C (1.00 ± 0.0 mSv) compared with protocol A (4.34 ± 0.0 mSv). The dose was reduced by 53% for protocol B and by 77% for protocol C. No significant differences were found in the effective dose among the different CM injection protocols within the scanning protocols; all p values were > 0.05. The attenuation values and SNRs were comparable among all the different CM injection protocols; all p values were > 0.05. CONCLUSION A large radiation dose reduction (77%) can be achieved using automated tube voltage selection independent of the CM injection protocol.
On regreening and degradation in Sahelian watersheds

Significance For decades, the science and policy narrative relating to the West African Sahel has focused on perceptions of overgrazing and human-induced desertification. More recent reports of regional-scale recovery (“regreening”) following the severe droughts of the 1970s and 1980s are sometimes ignored. This study provides a satellite-based evaluation of changes in watershed-scale vegetation conditions in four regions of the Sahel from 1983–2012. Though the results support earlier reports of a “greening” trend, our approach identified strong regional differences in the extent and direction of change, and in the apparent role of woody and herbaceous components in driving the temporal trend. Over many decades our understanding of the impacts of intermittent drought in water-limited environments like the West African Sahel has been influenced by a narrative of overgrazing and human-induced desertification. The desertification narrative has persisted in both scientific and popular conception, such that recent regional-scale recovery (“regreening”) and local success stories (community-led conservation efforts) in the Sahel, following the severe droughts of the 1970s–1980s, are sometimes ignored. Here we report a study of watershed-scale vegetation dynamics in 260 watersheds, sampled in four regions of Senegal, Mali, and Niger from 1983–2012, using satellite-derived vegetation indices as a proxy for net primary production. In response to earlier controversy, we first examine the shape of the rainfall–net primary production relationship and how it impacts conclusions regarding greening or degradation. We conclude that the choice of functional relationship has little quantitative impact on our ability to infer greening or degradation trends. We then present an approach to analyze changes in long-term (decade-scale) average rain-use efficiency (an indicator of slowly responding vegetation structural changes) relative to changes in interannual-scale rainfall sensitivity (an indicator of landscape ability to respond rapidly to rainfall variability) to infer trends in greening/degradation of the watersheds in our sample regions. The predominance of increasing rain-use efficiency in our data supports earlier reports of a “greening” trend across the Sahel. However, there are strong regional differences in the extent and direction of change, and in the apparent role of changing woody and herbaceous components in driving those temporal trends.
Differential modulation of Bax/Bcl-2 ratio and onset of caspase-3/7 activation induced by derivatives of Justicidin B in human melanoma cells A375

Diphyllin and its derivatives are well known cytotoxic natural products structurally related to the anti-cancer drug podophyllotoxin. We here study their structure-activity relationship upon human melanoma cells for first time. To this end, human melanoma A375 cells were incubated with Justicidin B and its 4-methoxylated or 4-glycosylated derivatives to evaluate their selective cytotoxicity and study their effects on cell cycle distribution, caspase activation, apoptosis induction using Annexin V-FITC/PI staining, cell morphology and western blot analysis. Diphyllin methyl ether (GI50 = 3.66 μM) and Justicidin B (GI50 = 1.70 μM) caused an elevation of both early and late apoptosis populations whereas Diphyllin apioside (GI50 = 0.84 μM) and its acetate (GI50= 0.39 μM) enhanced late apoptosis population only (Annexin V-positive/PI-positive). All induced cell cycle arrest at S phase and classic morphological indicators of apoptosis (blebbing, apoptotic bodies, and nuclear fragmentation) accompanied with an elevation of cells with low DNA content (sub-G1). All compounds increased the Bax/Bcl-2 ratio by enhancing Bax expression which evidences the involvement of the mitochondria (intrinsic pathway) in the apoptotic process. These caspase-3/7 results evidence that 4-methoxylation or 4-O-glycosylation of Justicidin B -a caspase independent mitochondrial apoptosis-inducer- triggers caspase-3/7 activation at different times (24h vs. 48h, respectively). Interestingly, the methoxylation causes attenuation of Bcl-2 protein expression contrarily to Diphyllin methyl ether or the O-glycosylated derivatives. Finally, the compounds exhibited significantly less toxicity when tested in adult human dermal fibroblasts and their GI50 in melanoma Sk-Mel-5 cells was not influenced by MDR1/Pgp inhibitors. This study may inform the synthesis of future Diphyllin derivatives with different apoptosis mechanism of action towards human melanoma cells.
Impact of hepatitis C on HIV progression in adults with alcohol problems.

BACKGROUND Coinfection of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is a substantial medical and public health concern due to its increasing prevalence and complex patient management. Alcohol use may worsen HCV-related liver disease and interfere with adherence to antiretroviral therapy (ART) and medical care. We therefore studied the association between HCV infection and markers of HIV disease progression in adults with alcohol problems. METHODS This is a longitudinal study of 396 HIV-infected persons with alcohol problems, 199 (50%) of whom were coinfected with HCV (positive HCV RNA test). CD4 cell counts and HIV RNA levels were assessed at baseline and then every 6 months for up to 42 months. Hepatitis C virus RNA status was determined at study enrollment. We examined the relationship between HCV infection and laboratory markers of HIV progression (CD4 cell count and log10 HIV RNA) by fitting multivariable longitudinal regression models for each outcome. RESULTS Among subjects who were adherent to ART, the presence of HCV infection was associated with a lower CD4 cell count (adjusted mean difference -46.0 cells/microL, p=0.03). There was no association observed between HCV infection and CD4 cell count among those not adherent to ART or those not taking ART. No significant association was observed between HCV infection and HIV RNA regardless of ART status. CONCLUSIONS Hepatitis C virus infection has an adverse effect on CD4 cell count in patients with alcohol problems who are adherent to ART. Addressing HCV coinfection among these patients may confer additional immunologic benefit for this patient population.
A built-in self-adjustment scheme with adaptive body bias using P/N-sensitive digital monitor circuits

This paper proposes a built-in self-adjustment scheme to adjust pMOSFET and nMOSFET performances to their target values. Independent control of MOSFET performances can boost circuit performance without large leakage overhead. All-digital monitor circuits have been developed to detect pMOSFET and nMOSFET variations. The scheme has been fabricated in a 65 nm process. Measurement results from corner chips confirm the validity of the scheme. At 0.7 V operation, more than 50% of circuit speed degradation has been recovered. The proposed scheme achieves 2.6 times leakage saving than the conventional critical path delay based scheme. The scheme is suitable for typical-case design and yield enhancement.
RAD IN DE NOVO RENAL TRANSPLANTATION: COMPARISON OF THREE DOSES ON THE INCIDENCE AND SEVERITY OF ACUTE REJECTION 1

Background. The effects of three doses of RAD(40-O-[2-hydroxyethyl]-rapamycin), a novel macrolide with potentimmunosuppressive and antiproliferative properties, on the incidence andseverity of acute rejection episodes as well as its tolerability wereevaluated in a dose-ranging study in de novo renal transplantrecipients. Methods. In this double-blind, parallel group, multicenter study,recipients were randomized to receive 1 mg, 2 mg, or 4 mg/day of RAD incombination with Neoral® (cyclosporine, USP MODIFIED) and corticosteroids.The incidence and severity of biopsy-proven acute rejection episodes, graftsurvival, patient survival, infection rates, laboratory measurements, andadverse events were compared across groups after 6 months oftherapy. Results. Among the 103 recipients, patients receiving 1, 2, or 4mg/day experienced a 32.4%, 14.7%, or 25.7% incidence of biopsy-proven acuterejection episodes within the first 6 months posttransplantation,respectively. Even though the study was not powered to demonstrate efficacy,the incidence of moderate and severe acute rejection episodes was found to besignificantly lower among patients in the 2 mg and 4 mg/day groups than in the1 mg/day group (P =0.002 and P =0.006, respectively). Overallgraft and patient survival rates were excellent. RAD was generally welltolerated. Although blood lipid levels increased in all groups, changes weremanageable with lipid-lowering agents and did not warrant discontinuation ofstudy medication. The incidence of viral and fungal infections was low;however, it was higher among recipients treated with 4mg/day. Conclusions. In combination with Neoral® and corticosteroids, RADdoses of 2 mg and 4 mg/day resulted in lower rates of acute rejection episodesand efficacy failure than the 1 mg/day dose and were significantly moreeffective in reducing the severity of rejection. Large-scale, controlled,follow-up studies are currently in progress to confirm these initialfindings.
Intrinsic circuitry in the deep layers of the cat superior colliculus

Abstract The mammalian superior colliculus is involved in the transformation of sensory signals into orienting behaviors. Sensory and motor signals are integrated in the colliculus to produce movements of the eyes, head, and neck. While there is a considerable amount of information available on the afferent and efferent connections of the colliculus, almost nothing is known about its intrinsic circuitry, particularly that of its deepest layers. It is likely that intrinsic connections in these deeper layers of the colliculus participate in the sensory-motor transformations leading to orienting movements. In this study, we used the neuroanatomical tracer biocytin to label small groups of neurons in the deeper layers of the cat superior colliculus and examine the distribution of their axons and terminals. We found a broadly distributed network of intrinsic projections throughout the deep layers of the superior colliculus. While the majority of terminals were found in a 1–2 mm radius around the injection site, labeled terminals were found throughout the deep layers of the colliculus up to 5 mm from the injection site. In addition, these injections sometimes labeled terminals in the superficial tectum. Extensive projections were demonstrated by the more superficial injections, but few terminals were found when injections were confined to the deepest layers of the colliculus. There was no evidence of anisotropy in the distribution of terminals from injections made at different rostrocaudal or mediolateral locations; neurons located in any one region in the colliculus could potentially influence any other region. This network of intrinsic connections in the cat superior colliculus could provide a means for deeper-layer efferent neurons to associate, and to modulate or coordinate their output. Interneurons could also provide a substrate for mutual inhibition between neurons at the rostral pole of the colliculus that are active during fixation, and more caudally located neurons whose activity is associated with saccadic eye movements.
Depression in patients with hidradenitis suppurativa

Background Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory skin disease with abscess formation and scarring predominantly in the inverse areas. The disease is often difficult to treat and patients experience a decreased quality of life (QoL). It is hypothesized that depression is more common in HS patients than among other dermatological patients.
The Impact of Arterial Input Function Determination Variations on Prostate Dynamic Contrast-Enhanced Magnetic Resonance Imaging Pharmacokinetic Modeling: A Multicenter Data Analysis Challenge

Pharmacokinetic analysis of dynamic contrast-enhanced (DCE) MRI data allows estimation of quantitative imaging biomarkers such as Ktrans (rate constant for plasma/interstitium contrast reagent (CR) transfer) and ve (extravascular and extracellular volume fraction). However, the use of quantitative DCE-MRI in clinical practice is limited with uncertainty in arterial input function (AIF) determination being one of the primary reasons. In this multicenter study to assess the effects of AIF variations on pharmacokinetic parameter estimation, DCE-MRI data acquired at one center from 11 prostate cancer patients were shared among nine centers. Individual AIF from each data set was determined by each center and submitted to the managing center. These AIFs, along with a literature population averaged AIF, and their reference-tissue-adjusted variants were used by the managing center to perform pharmacokinetic data analysis using the Tofts model (TM). All other variables, including tumor region of interest (ROI) definition and pre-contrast T1, were kept constant to evaluate parameter variations caused solely by AIF discrepancies. Considerable parameter variations were observed with the within-subject coefficient of variation (wCV) of Ktrans obtained with unadjusted AIFs being as high as 0.74. AIF-caused variations were larger in Ktrans than ve and both were reduced when reference-tissue-adjusted AIFs were used. These variations were largely systematic, resulting in nearly unchanged parametric map patterns. The intravasation rate constant, kep (= Ktrans/ve), was less sensitive to AIF variation than Ktrans (wCV for unadjusted AIFs: 0.45 vs. 0.74), suggesting that it might be a more robust imaging biomarker of prostate microvasculature than Ktrans.
Variants in Follicle-Stimulating Hormone Receptor Gene in Infertile Brazilian Men and the Correlation to FSH Serum Levels and Sperm Count

The aim of the study was to analyze the distribution of the follicle-stimulating hormone (FSH) receptor (FSHR) Ala307Thr and Asn680Ser polymorphisms in infertile Brazilian men and evaluate the possible role of these polymorphisms on the serum levels of FSH and in sperm count. A case–control study was performed comprising138 infertile men with nonobstructive azoospermia (n = 53) or severe oligozoospermia (n = 85), and 217 fertile men as controls. Genotyping of FSHR polymorphisms was performed by real-time polymerase chain reaction (PCR). The results were analyzed statistically and a P value <. 05 was considered significant. According to the sperm count, relatively similar FSHR polymorphisms genotype and allele frequencies were found among the groups, and combined genotypes of 2 polymorphisms did not identify a haplotype associated with sperm count. Considering FSH serum level according to genotypes of the Ala307Thr and Asn680Ser polymorphisms individually, statistical analysis showed no difference among the groups. When the combined genotypes of the FSHR polymorphisms were compared to FSH serum levels, no difference was also found among the groups. In conclusion, the findings demonstrate that, in Brazilian population studied, genetic variations, Asn680Ser and Thr307Ala, of the FSHR gene are not correlated with serum FSH levels or sperm count in male infertility.
High-LET Radiation Induces Inflammation and Persistent Changes in Markers of Hippocampal Neurogenesis

Abstract Rola, R. , Sarkissian, V. , Obenaus, A. , Nelson, G. A. , Otsuka, S. , Limoli, C. L. and Fike, J. R. High-LET Radiation Induces Inflammation and Persistent Changes in Markers of Hippocampal Neurogenesis. Radiat. Res. 164, 556–560 (2005). Exposure to heavy-ion radiation is considered a potential health risk in long-term space travel. It may result in the loss of critical cellular components in complex systems like the central nervous system (CNS), which could lead to performance decrements that ultimately could compromise mission goals and long-term quality of life. Specific hippocampal-dependent cognitive impairment occurs after whole-body 56Fe-particle irradiation, and while the pathogenesis of this effect is not yet clear, it may involve damage to neural precursor cells in the hippocampal dentate gyrus. We irradiated mice with 1–3 Gy of 12C or 56Fe ions and 9 months later quantified proliferating cells and immature neurons in the dentate subgranular zone (SGZ). Our results showed that reductions in these cells were dependent on the dose and LET. When compared with data for mice that were studied 3 months after 56Fe-particle irradiation, our current data suggest that these changes are not only persistent but may worsen with time. Loss of precursor cells was also associated with altered neurogenesis and a robust inflammatory response. These results indicate that high-LET radiation has a significant and long-lasting effect on the neurogenic population in the hippocampus that involves cell loss and changes in the microenvironment.
Determinants of Automated Teller Machine Usage in Lagos State, Nigeria

Abstract Research has shown that ATMs provide an extremely useful service to customers but the machine is characterized by several service quality inadequacies, and at times it can be very frustrating to use. Consequently, this study investigated socio-demographic factors and service quality dimensions as determinants of ATM usage in Lagos State, Nigeria. A questionnaire was used to collect data from bank customers who use ATM and the data were analysed using General Linear Model (GLM) and multiple regression. The results from the analyses reveal that socio-demographic factors, such as age, education, and income, influence ATM usage, while gender and occupation do not influence ATM usage. The study also revealed that all the service quality dimensions identified in the study have a significant positive influence on ATM usage. When the joint effect of socio-demographic factors and service quality dimensions on ATM usage was assessed, it was found that service quality had a greater influence on ATM usage than socio-demographic factors.
Alcohol Intoxicated Witnesses: Perception of Aggression and Guilt in Intimate Partner Violence

Many witnesses to violent crimes are alcohol intoxicated, but research is lacking regarding how alcohol affects their perception of aggression and guilt. This study investigated to what extent alcohol intoxicated eyewitnesses differed from sober witnesses regarding how aggressive and guilty they perceived the involved parts in an intimate partner violence (IPV) situation. Eighty-seven healthy men (n = 44) and women (n = 43) were randomized to an alcohol group (0.7 g/kg) or a non-alcohol group. In a laboratory setting, alcoholic/non-alcoholic drinks were consumed before viewing a film depicting IPV between a man and a woman. Ten min after viewing, in an interview, the participants rated how aggressive and guilty they perceived the involved parts to be. Alcohol intoxicated participants perceived both parts’ physically aggressive behavior as comparatively less severe, but their neutral behavior as more hostile. Sober witnesses perceived the man to be the most guilty part, whereas intoxicated witnesses distributed guilt more evenly. Alcohol had a strong but complex impact on the perception of aggression in IPV (i.e., heightened during the neutral interaction and lowered during physical aggression). These results may be explained by the cognitive consequences of alcohol’s anxiety-dampening effects. Regarding the asymmetric difference in perceived guilt, stereotypical expectations of gender-appropriate behavior in an IPV situation may need to be considered.
Modeling American Household Fluid Milk Consumption and their Resulting Greenhouse Gas Emissions

U.S. consumers are the largest contributors to food waste generation (FWG), but few models have explained how households waste food. This study examines how discrete-event simulation (DES) can identify areas for reducing FWG through packaging and consumer milk consumption behavioral changes. Household model parameters included: amount and type of consumption, type and number of containers bought, buying behavior, and shelf life of milk. Simulations comparing the purchase of quart, half gallon, and gallon milk containers were run for 10,000 days to identify which package type reduced waste for 50 1, 2 and 4-person households. Based on consumption averages from the U.S. National Dairy Council, results suggest that if 1 and 4-person households change their purchasing behavior from 1 half-gallon to 1 quart and 2 gallons to 3 half-gallons, they can reduce their greenhouse gas (GHG) emissions from milk consumption by 33% and 12%, respectively, without reducing their total milk consumption. Purchasing enough smaller containers to be equivalent to a larger size decreased spoilage, but not enough to reduce a consumer’s total milk consumption GHG emissions. Results showed that packaging accounts for 5% of the total milk consumption GHG emissions; most of a consumer’s impact comes from milk spoilage and consumption.
MODEL ESTIMATION OF THE WHOLE LIFE COST OF A BUILDING WITH RESPECT TO RISK FACTORS

The paper deals with estimating the life cycle cost and the whole life cost of a building. An original model for estimating the life cycle cost and the whole life cost of a building which allows the quantification of the increase in costs resulting from the incurred and assessed risk is presented. The proposed model consists of two basic parts: module I evaluating the impact of identified risk factors on individual element of the life cycle cost, and module II allowing to assess life cycle cost including the risk factors selected in module I. In module I the model of fuzzy inference of Mamdani was used. The structure of module II is based on the theory of possibilities and fuzzy sets. The operation of the model is presented on the example of an office building.