Miracle-dz/UniFAR-FTUs huggingface dataset:
Flexible Nonlinear Periodization in a Beginner College Weight Training Class

McNamara, JM and Stearne, DJ. Flexible Nonlinear Periodization in a Beginner College Weight Training Class. J Strength Cond Res 24(8): 2012-2017, 2010-The purpose of this study was to determine the effect of a flexible nonlinear (FNL) periodized weight training program compared to a nonlinear (NL) periodized weight training program on strength and power. Sixteen beginner weight training students were randomly assigned to an FNL group (n = 8) or an NL group (n = 8). The exercise program included a combination of machines and free weights completed in 30 minutes, twice per week, for 12 consecutive weeks. Both groups were assigned the same total training volume of 3,680 repetitions and the same total training repetition maximum assignments of 10, 15, and 20. The FNL group, however, was allowed to choose which day they completed the 10, 15, or 20 repetition workout. This was the only difference between the groups. Pre- and post-test measures included chest press, leg press, and standing long jump. The FNL group significantly improved by an average increase of 62 kg (p < 0.05), whereas the NL group only increased by an average of 16 kg in the leg press. The FNL group did not significantly differ in chest press or standing long jump performance when compared to the NL group. The conclusion from this study is that an FNL periodization program may be a highly effective method of training for improving leg strength. Coaches can immediately implement an FNL program by evaluating the readiness of an athlete immediately before his or her training session, then adjusting the assigned exercise intensity accordingly.
The Physiological Role of Ferritin-Like Compounds in Bacteria

Iron, as the ferrous or ferric ion, is essential for the life processes of all eukaryotes and most prokaryotes; however, the element is toxic when in excess of that needed for cellular homeostasis. Ferrous ions can react with metabolically generated hydrogen peroxide to yield toxic hydroxyl radicals that in turn degrade lipids, DNA, and other cellular biomolecules. Mechanisms have evolved in living systems for iron detoxification and for the removal of excess ferrous ions from the cytosol. These detoxification mechanisms involve the oxidation of excess ferrous ions to the ferric state and storage of the ferric ions in ferritin-like proteins. There are at least three types of ferritin-like proteins in bacteria: bacterial ferritin, bacterioferritin, and dodecameric ferritin. These bacterial proteins are related to the ferritins found in eukaryotes. The structure and physical characteristics of the ferritin-like compounds have been elucidated in several bacteria. Unfortunately, the physiological roles of the bacterial ferritin-like compounds have been less thoroughly studied. A few studies conducted with mutants indicated that ferritin-like compounds can protect bacterial cells from iron overload, serve as an iron source when iron is limited, protect the bacterial cells against oxidative stress and/or protect DNA against enzymatic or oxidative attack. There is very little information available concerning the roles that ferritin-like compounds might play in the survival of bacteria in food, water, soil, or eukaryotic host environments.
Control strategy for open winding PMSM system supplied by the Z-source and voltage source integrated converters

In this paper, a control strategy for open winding PMSM system collaboratively supplied by the bidirectional Z-source and voltage source converters is proposed. The modified SVPWM for bidirectional Z-source inverter and the zero-sequence current circuit is analyzed in this open winding PMSM system. A strategy of zero-sequence current suppression is employed and the space vectors of converters on both sides are redistributed. The control system with a bidirectional Z-source inverter can work in both motoring and generating modes, and with a flexible dc bus voltage on one side, the phase voltage of PMSM can achieve a boost and the motor can operate in a larger range of speed. The availability of the proposed control strategy is validated by the simulation of MATLAB/Simulink based on the 10kW open winding PMSM system.
Prevalence and distribution of sensitization to foods in the European Community Respiratory Health Survey: a EuroPrevall analysis

To cite this article: Burney P, Summers C, Chinn S, Hooper R, van Ree R, Lidholm J. Prevalence and distribution of sensitization to foods in the European Community Respiratory Health Survey: a EuroPrevall analysis. Allergy 2010; 65: 1182–1188.
Cross-Provider Cooperation for Improved Network-Based Localization

This paper considers the problem of network-based mobile-phone positioning when multiple providers are available. This paper proposes two cross-provider localization algorithms via a cooperative approach, which are called linear regression (LR) and locally cooperative embedding (LCE), to efficiently exploit the complementary information from each network provider. The former chooses the provider weights that minimize the mean-square positioning errors. The latter dynamically embeds the cooperation and iteratively refines the positioning process according to each provider's local accuracy surrounding the user. This paper applies the proposed cross-provider positioning algorithms to actual Global System for Mobile Communications (GSM) networks, using a dual-subscriber-identity-module (SIM) mobile phone connecting to multiple providers simultaneously. On-site experiments clearly demonstrated that the proposed cross-provider approaches provide better positioning accuracy than any individual provider, where LCE achieves the best performance.
Cytotoxic Grifolin Derivatives Isolated from the Wild Mushroom Boletus pseudocalopus (Basidiomycetes)

Activity‐guided purification of a MeOH extract of the Korean wild mushroom Boletus pseudocalopus afforded three new grifolin derivatives, 1–3, along with four known phenolic compounds 4–7. Their structures were established by a combination of 1H‐ and 13C‐NMR, NOESY, and extensive two‐dimensional NMR spectroscopic experiments such as gCOSY, gHSQC, gHMBC, and ROESY. The major metabolites 4 and 5 were subjected to reduction to provide the side chain‐reduced compounds 8 and 9 for biological testing. All of the compounds except compound 6 showed anticancer activities in the range of IC50 3.5–11.0 μg/ml against human lung carcinoma A549 and mouse melanoma B16F1 cell lines. In addition, all compounds showed moderate radical‐scavenging activities determined by DPPH assay.
A Pipelined and Scalable Dataflow Implementation of Convolutional Neural Networks on FPGA

Convolutional Neural Network (CNN) is a deep learning algorithm extended from Artificial Neural Network (ANN) and widely used for image classification and recognition, thanks to its invariance to distortions. The recent rapid growth of applications based on deep learning algorithms, especially in the context of Big Data analytics, has dramatically improved both industrial and academic research and exploration of optimized implementations of CNNs on accelerators such as GPUs, FPGAs and ASICs, as general purpose processors can hardly meet the ever increasing performance and energy-efficiency requirements. FPGAs in particular are one of the most attractive alternative, as they allow the exploitation of the implicit parallelism of the algorithm and the acceleration of the different layers of a CNN with custom optimizations, while retaining extreme flexibility thanks to their reconfigurability. In this work, we propose a methodology to implement CNNs on FPGAs in a modular, scalable way. This is done by exploiting the dataflow pattern of convolutions, using an approach derived from previous work on the acceleration of Iterative Stencil Loops (ISLs), a computational pattern that shares some characteristics with convolutions. Furthermore, this approach allows the imple- mentation of a high-level pipeline between the different network layers, resulting in an increase of the overall performance when the CNN is employed to process batches of multiple images, as it would happen in real-life scenarios.
Pathologic Diagnosis of Recurrent Glioblastoma: Morphologic, Immunohistochemical, and Molecular Analysis of 20 Paired Cases

To evaluate the prognostic value of the volume of residual viable tumor versus therapy-induced necrosis in resection material and the diagnostic value of ancillary tests in recurrent glioblastoma (GBM), we conducted a retrospective review of 20 patients whose initial and recurrent specimens were available. Recurrent GBMs were graded according to the extent of histopathologic parameters: recurrent tumor with high-grade, non–high-grade, and pure high-grade tumor components and therapy-related necrosis. We also examined MIB-1 labeling, isocitrate dehydrogenase 1R132H mutation, and epidermal growth factor receptor amplification in primary and recurrent GBMs. To evaluate patient outcomes according to clinical and pathologic parameters, a survival analysis was performed, and correlations between histopathologic parameters and each ancillary test were assessed. Among clinical parameters, age above 60 years was associated with decreased survival (P=0.022), but other clinical parameters showed no significant association with overall survival. Among the 3 histopathologic parameters, the extent of recurrent tumor, including high-grade and non–high-grade components, revealed a significant association with overall survival (P=0.042), but neither the extent of pure high-grade components nor therapy-related necrosis showed any prognostic value. MIB-1 labeling, isocitrate dehydrogenase 1R132H mutation, and epidermal growth factor receptor amplification were useful for the diagnosis of recurrent GBMs but showed no prognostic value. Our data suggest that histopathologic evaluation on the basis of tumor extent in resected recurrent GBM specimens may provide additional prognostic information on the survival of patients with recurrent GBM.
Effects of low-dose capecitabine on Samarium-153-EDTMP therapy for painful bone metastases

Introduction: Samarium-153 (Sm-153)-EDTMP is routinely used for pain palliation in skeletal metastasis, however most patients report partial response. Many strategies have been contemplated to make radiation therapy for pain more effective, one of them being the use of radiosensitizers. Capecitabine is a chemotherapeutic drug and is routinely combined with external beam radiation to make the target more radio-sensitive. Aim of the study was to evaluate whether combining capecitabine in radiosensitizing dose with Sm-153-EDTMP produces superior analgesia compared to Sm alone. Materials and Methods: Forty-four patients with skeletal metastases from various primaries were randomized into two groups: The study group received 1 mCi/kg Sm-153-EDTMP plus capecitabine (1,650 mg/m2) orally for 8 days (equivalent to four t½ of 153Sm-EDTMP) and the control arm received 1 mCi/kg Sm-153-EDTMP plus placebo for the 8 days. After treatment, the patients were followed up for 12 weeks to evaluate the degree and duration of pain palliation and hematologic toxicity. Results: All 44 patients reported different degrees of pain relief with none reporting complete pain relief for the entire duration of 12 weeks posttherapy observation period. However the level of pain relief obtained in study arm was significantly better than the control arm with mean posttherapy pain score being 1.29 ± 1.05 and 3.59 ± 2.77 respectively with P of 0.001. Transient and mild hematologic toxicity, as determined by World Health Organization criteria, was apparent in both arms without significant differences. Conclusion: The addition of a low-dose of capecitabine significantly enhances the analgesic effect of Sm-153 without any additional side effects.
Oxide-confined monolithic, multiple-wavelength vertical-cavity surface-emitting laser arrays with a 40-nm wavelength span

Monolithic, multiple-wavelength, vertical-cavity surface-emitting laser arrays grown by controlling the metal-organic chemical vapor deposition epitaxial growth rate on a patterned substrate, and using selective oxidation for current confinement, have been demonstrated with a periodic, graded wavelength span of 40 nm, Near room-temperature, electrically pumped continuous-wave lasing is achieved over the entire 40-nm range, with uniform threshold currents of 4.5 mA/spl plusmn/1.0 mA, and with output powers ranging from 0.4-1.3 mW.
Transdermal delivery of estradiol-loaded PLGA nanoparticles using iontophoresis for treatment of osteoporosis.

BACKGROUND Estradiol is one of the therapeutic agents for osteoporosis. We have reported transdermal permeability of estradiol-loaded nanoparticles, and permeability effect of estradiol was enhanced by using nanoparticle system and iontophoresis [Colloids and Surfaces B: Biointerfaces97 (2012), 84-89]. OBJECTIVE This study was conducted in vivo to evaluate therapeutic efficacy of the estradiol-loaded PLGA nanoparticles for osteoporosis. METHODS Prior to the in vivo study, we have determined the surface charge density of the particles and found they have negatively charged polyelectrolyte layers on the surfaces. Ovariectomized female Sprague-Dawley rats were used as an animal model of osteoporosis. They were separated into three groups by administration route of estradiol-loaded PLGA nanoparticles, passive diffusion group, iontophoresis group and control. After treatment, we have measured bone mineral density of spine using an X-ray computed tomography system. RESULTS Bone mineral density after iontophoresis was significantly higher than that of passive diffusion and control group. By usage of iontophoresis, the nanoparticles were permeated through follicles and migrated into capillary vessel around follicles, and the loaded drug reached effective blood concentration in plasma of rat. CONCLUSIONS From this study, we found that the combination with charged nanoparticle system and iontophoresis is useful to osteoporosis treatment.
A modified hybrid multi-level converter for high-power high-frequency IPT systems

IPT technology has been increasingly used in EV charging systems. However, fast charging using IPT technology is still a concern due to high-power high-frequency operation. This paper presents a low cost modified MOSFET-IGBT multi-level converter that is suitable for high power and high frequency IPT systems. The proposed converter with a reduced number of switches can be employed on both sides of IPT systems to generate high track currents that are necessary for high power applications. The performance of the converter is investigated through comparison of the simulated model under various operating conditions. The simulate results, compared with a conventional hybrid multi-level topology, clearly show that the conduction losses and the cost of materials are reduced in the proposed converter.
Delaying the onset of M phase in NIH 3T3 cells blocked in early S phase occurs via accumulating cyclin B1 and tyrosine‐phosphorylated p34cdc2 in the nucleus

An affinity‐purified antibody (anti‐Cdc2C) raised against the carboxy terminal sequence LDNQIKKM of p34cdc2 uncovered in NIH 3T3 cells a protein subpopulation, the location and the level of accumulation of which evolve during progression through the cell cycle: it first emerges inside the nucleus in late G1/early S phase and continues to build up principally in this location throughout S phase; a cytoplasmic expression then becomes apparent near the end of S phase, develops during G2 and sometimes prevails over the nuclear expression; it finally relocates to the nucleus in early prophase. We propose that a major part of this subpopulation would represent p34cdc2 molecules existing inside a complex with cyclin B1. NIH 3T3 cells arrested in early S phase with aphidicolin do not commit prematurely to mitosis which indicates that the regulatory pathway involved in preserving the temporal order of S and M phases is functioning in these conditions. Conjugated Western blot analysis and immunofluorescence microscopy showed that cyclin A, cyclin B1 and tyrosine‐phosphorylated p34cdc2 continue to build up predominantly in the nucleus of the arrested cells. After release from the block, the cells rapidly reenter S and G2 phases and, concomitantly, cyclin B1 and tyrosine‐phosphorylated p34cdc2 relocate to the cytoplasm before redistributing again in the nucleus in early prophase. These data would suggest that delaying the onset of M phase in NIH 3T3 cells in which the rate of DNA replication is reduced, is first ensured by a mechanism that prevents the cytoplasmic relocation of inactive p34cdc2/cyclin B1 complexes continually forming in the nucleus once the G1 period of mitotic cyclin instability is over.
Lipid hydroperoxide stimulates subretinal choroidal neovascularization in the rabbit.

The authors sought to evaluate the effect of linoleic acid hydroperoxide (18:2/LHP) in promoting choroidal neovascularization (CNV). Albino male rabbits received a subretinal injection of various amounts of LHP (ranging from 5 to 200 microg) dissolved in 50 microl of sodium borate buffer. Control eyes received the buffer only. Eyes were examined up to 4 weeks later with indirect ophthalmoscopy, fundus photography and fluorescein angiography. Animals were killed on days 3, 7, 14 or 28, and eyes examined by light and transmission electron microscopy. In eyes injected with LHP of 150-200 microg, exposed areas turned white as observed ophthalmoscopically and showed both severe retinal and choroidal atrophy histologically. Neither fluorescein leakage nor CNV was found in these eyes or in controls. In 33 eyes injected with LHP of 100 microg or less, prominent fluorescein leakage was seen in three (9%) and less prominent focal leakage in five (15%). In 11 (46%) of the 24 eyes injected with 12.5-50 microg LHP, CNV was found histologically. Subretinal injection of LHP is capable of inducing CNV.
A Transitional Gundi (Rodentia: Ctenodactylidae) from the Miocene of Israel

We describe a new species of gundi (Rodentia: Ctenodactylidae: Ctenodactylinae), Sayimys negevensis, on the basis of cheek teeth from the Early Miocene of the Rotem Basin, southern Israel. The Rotem ctenodactylid differs from all known ctenodactylid species, including Sayimys intermedius, which was first described from the Middle Miocene of Saudi Arabia. Instead, it most resembles Sayimys baskini from the Early Miocene of Pakistan in characters of the m1-2 (e.g., the mesoflexid shorter than the metaflexid, the obliquely orientated hypolophid, and the presence of a strong posterolabial ledge) and the upper molars (e.g., the paraflexus that is longer than the metaflexus). However, morphological (e.g., presence of a well-developed paraflexus on unworn upper molars) and dimensional (regarding, in particular, the DP4 and M1 or M2) differences between the Rotem gundi and Sayimys baskini distinguish them and testify to the novelty and endemicity of the former. In its dental morphology, Sayimys negevensis sp. nov. shows a combination of both the ultimate apparition of key-characters and incipient features that would be maintained and strengthened in latter ctenodactylines. Thus, it is a pivotal species that bridges the gap between an array of primitive ctenodactylines and the most derived, Early Miocene and later, gundis.
Smoking initiation and cessation by gender and educational level in Catalonia, Spain.

BACKGROUND The role of gender and socioeconomic status in smoking has been characterized in the United States and Northern European countries. However, there is scarce information of the dynamic of the tobacco epidemic in Southern European countries. The aim of this study was to analyze smoking initiation and cessation according to level of education and gender in Catalonia, Spain. METHODS Data from the Catalan Health Survey (1994), a cross-sectional study based in a representative sample of the noninstitutionalized population of Catalonia, was used. The relative risks and 95% confidence interval of smoking initiation were computed by means of Cox's regression. The odds ratios and 95% confidence intervals of quitting smoking were derived from logistic regression models. Direct responses from 4,370 men and 5,213 women ages 25 years or over were included for analysis. RESULTS Ever smoking was inversely related to level of education in men. Males with the highest educational level tended to have a lower probability of being a smoker at a given age than those with less than primary school (relative risk = 0.6; 95% confidence interval: 0.5-0.7). This pattern appeared with small variation across age groups. In women, a reverse trend was present: the higher the level of education the higher the relative risk of starting smoking (relative risk = 4.6; 95% confidence interval: 3.1-6.7). Quitting smoking was more likely among men and women with higher education as compared to men and women with less than primary school (men: odds ratio = 1.5; 95% confidence interval 1.1-2.1; women: odds ratio = 4.6; 95% confidence interval: 2.1-10.4). CONCLUSIONS The differential effect of education according to gender may reflect different phases of the smoking epidemic. In Catalonia, the transition of smoking from upper and lower socioeconomic groups occurred recently among men, and women have currently begun to experience this transition.
Osteoblastic γ-Aminobutyric Acid, Type B Receptors Negatively Regulate Osteoblastogenesis toward Disturbance of Osteoclastogenesis Mediated by Receptor Activator of Nuclear Factor κB Ligand in Mouse Bone*

The prevailing view is that signaling machineries for the neurotransmitter GABA are also expressed by cells outside the CNS. In cultured murine calvarial osteoblasts, mRNA was constitutively expressed for both subunits 1 and 2 of metabotropic GABAB receptor (GABABR), along with inhibition by the GABABR agonist baclofen of cAMP formation, alkaline phosphatase (ALP) activity, and Ca2+ accumulation. Moreover, baclofen significantly inhibited the transactivation of receptor activator of nuclear factor-κB ligand (RANKL) gene in a manner sensitive to a GABABR antagonist, in addition to decreasing mRNA expression of bone morphogenetic protein-2 (BMP2), osteocalcin, and osterix. In osteoblastic MC3T3-E1 cells stably transfected with GABABR1 subunit, significant reductions were seen in ALP activity and Ca2+ accumulation, as well as mRNA expression of osteocalcin, osteopontin, and osterix. In cultured calvarial osteoblasts from GABABR1-null mice exhibiting low bone mineral density in tibia and femur, by contrast, both ALP activity and Ca2+ accumulation were significantly increased together with promoted expression of both mRNA and proteins for BMP2 and osterix. No significant change was seen in the number of multinucleated cells stained for tartrate-resistant acid phosphatase during the culture of osteoclasts prepared from GABABR1-null mice, whereas a significant increase was seen in the number of tartrate-resistant acid phosphatase-positive multinucleated cells in co-culture of osteoclasts with osteoblasts isolated from GABABR1-null mice. These results suggest that GABABR is predominantly expressed by osteoblasts to negatively regulate osteoblastogenesis through down-regulation of BMP2 expression toward disturbance of osteoclastogenesis after down-regulation of RANKL expression in mouse bone.