Miracle-dz/UniFAR-FTUs huggingface dataset:
Network Assisted Mobility Support for 6LoWPAN

This paper presents a network-assisted mobility support scheme for 6LoWPAN nodes, which enables multi-hop communication between the Gateway (GW) and the Mobile 6LoWPAN devices (MNs), with minimum mobility related signaling at the MN's end as compared to conventional mobility related protocols like MIPv6. The scheme provides mobility support to the MNs with the help of low cost static 6LoWPAN devices (SNs) which can be deployed in large numbers. In order to reduce the handover latency, the MN in the proposed scheme is assigned a fixed address which remains unchanged during its course of movement within the network. Moreover the scheme aims to reduce packets loss of the MN by predicting its future location and having a provision of buffering its packet at SNs when needed. The signaling overhead consumption needed to support a MN is determined through analytical modeling.
Superion Interspinous Process Spacer for Intermittent Neurogenic Claudication Secondary to Moderate Lumbar Spinal Stenosis: Two-Year Results From a Randomized Controlled FDA-IDE Pivotal Trial

Study Design. Prospective, multicenter, randomized, controlled, investigational device exemption noninferiority trial. Objective. To determine 2-year outcomes in patients with intermittent neurogenic claudication secondary to moderate lumbar spinal stenosis (LSS) who were treated with the Superion interspinous process spacer. Summary of Background Data. Interspinous spacers are a less-invasive treatment alternative compared with surgical decompression for patients with LSS unresponsive to conservative care. High-quality comparative data with these devices are lacking. Methods. Patients presenting with intermittent neurogenic claudication secondary to moderate LSS who failed at least 6 months of nonsurgical management were randomly allocated to treatment with the Superion spacer or a control spacer (X-Stop) and followed for 2 years. Results. A total of 391 randomized patients were implanted with Superion (n = 190) or control (n = 201) spacers at 29 sites in the United States between August 2008 and December 2011. Implants were successfully implanted in 99.5% of patients with Superion and 99.0% of control patients. The primary composite endpoint of this study was met, which demonstrated that the Superion spacer was noninferior to the X-Stop spacer. Leg pain, the predominant patient complaint, decreased in severity by 70% during 2 years in each group. Most (77%) patients achieved leg pain clinical success (improvement ≥20 mm) at 2 years. Back pain clinical success (improvement ≥20 mm) was 68%, with no differences between groups. Oswestry Disability Index clinical success (≥15% point improvement) was achieved in 65% of patients. The rates of complications and reoperations were similar between groups. Conclusion. The Superion interspinous process spacer relieves symptoms of intermittent neurogenic claudication secondary to moderate LSS in the majority of patients through 2 years. Level of Evidence: 2
BrpA Is Involved in Regulation of Cell Envelope Stress Responses in Streptococcus mutans

ABSTRACT Previous studies have shown that BrpA plays a major role in acid and oxidative stress tolerance and biofilm formation by Streptococcus mutans. Mutant strains lacking BrpA also display increased autolysis and decreased viability, suggesting a role for BrpA in cell envelope integrity. In this study, we examined the impact of BrpA deficiency on cell envelope stresses induced by envelope-active antimicrobials. Compared to the wild-type strain UA159, the BrpA-deficient mutant (TW14D) was significantly more susceptible to antimicrobial agents, especially lipid II inhibitors. Several genes involved in peptidoglycan synthesis were identified by DNA microarray analysis as downregulated in TW14D. Luciferase reporter gene fusion assays also revealed that expression of brpA is regulated in response to environmental conditions and stresses induced by exposure to subinhibitory concentrations of cell envelope antimicrobials. In a Galleria mellonella (wax worm) model, BrpA deficiency was shown to diminish the virulence of S. mutans OMZ175, which, unlike S. mutans UA159, efficiently kills the worms. Collectively, these results suggest that BrpA plays a role in the regulation of cell envelope integrity and that deficiency of BrpA adversely affects the fitness and diminishes the virulence of OMZ175, a highly invasive strain of S. mutans.
Emotion Regulation in Children and Adolescents

Within the past two decades, an "affect revolution" [Fischer and Tangney, Self-conscious Emotions: The Psychology of Shame, Guilt, Embarrassment, and Pride 1995:3-22] in research has revolutionized the ways in which emotion processes have been conceptualized and subsequently studied. This review discusses the literature on emotion regulation (ER) in childhood and adolescence by first summarizing the trajectory of emotional development from infancy through adolescence, followed by a discussion of the biological and environmental influences on ER, and then a review of the literature linking ER to psychosocial functioning. The penultimate section offers practical suggestions for identifying ER difficulties in children and strategies for intervention efforts. Potential areas for future research conclude the review.
Status of the RIKEN RIB factory

The first outcome from a newly operational RJ beam facility called the RIKEN RIB Factory was obtained in the first test experiment conducted in the last week of May 2007. A new very neutron-rich isotope, Pd-125 was discovered in the in-flight fission of U-238 isotopes accelerated up to 345 MeV/nucleon. Since 1997, RIKEN has been constructing this facility, where three new ring cyclotrons with K-values of 570 MeV, 980 MeV and 2600 MeV, respectively, boost energies of the output beams from the existing K540-MeV ring cyclotron up to 440 MeV/nucleon for light ions and 350 MeV/nucleon for very heavy ions. The K2600-MeV ring cyclotron is the world's first ring cyclotron with superconducting sector magnets. These energetic heavy-ion beams are converted into intense RI beams via projectile fragmentation of stable isotopes or in-flight fission of uranium isotopes by a superconducting fragment separator.
Myosin-I in retinal pigment epithelial cells.

PURPOSE Myosin-I is a nonfilamentous motor protein associated with the actin cytoskeleton and cellular membranes in several cell types. The occurrence and subcellular distribution of myosin-I in mammalian and fish RPE were investigated to examine the possible role of myosin-I in retinal pigment epithelium (RPE) motility processes. METHODS Antibodies directed against myosin-I proteins from bovine adrenal medulla or chicken intestinal brush border were used to examine cultured fetal human RPE cells and freshly isolated bovine or green sunfish RPE by Western immunoblots and immunocytochemistry, using both conventional and confocal fluorescence microscopy. RESULTS The monoclonal antibody directed against bovine adrenal myosin-I identified a single strong immunoreactive band at 116 kD in Western blots of homogenates of cultured human RPE cells and 114 kD in bovine RPE sheets. An immunoreactive band of similar molecular weight was also observed in bovine and rabbit retina. Cell fractionation studies of bovine RPE cells revealed that myosin-I was present in all fractions that included cell membranes. The polyclonal antibody directed against chicken brush border myosin-I identified doublet immunoreactive bands at 115/110 kD in Western blots of homogenates of fish retina but identified a strong predominant immunoreactive band at 140 kD in fish RPE and brain homogenates; minor bands at 115/110 kD were identified in fish RPE homogenates. Immunocytochemistry of cultured human RPE cells using the bovine adrenal myosin-I antibody revealed a broad distribution of myosin-I that appeared to be most concentrated along the length of the lateral membranes; no colocalization was seen with actin-rich stress fibers. CONCLUSIONS Proteins immunoreactive with myosin-I antibodies are present in both RPE and retina of mammals and green sunfish. In confluent cultures of human RPE cells, myosin-I is concentrated along the lateral cell membranes of the cuboidal cells.
A Review of Remote Sensing Image Classification Techniques: the Role of Spatio-contextual Information

Abstract This paper reviewed major remote sensing image classification techniques, including pixel-wise, sub-pixel-wise, and object-based image classification methods, and highlighted the importance of incorporating spatio-contextual information in remote sensing image classification. Further, this paper grouped spatio-contextual analysis techniques into three major categories, including 1) texture extraction, 2) Markov random fields (MRFs) modeling, and 3) image segmentation and object-based image analysis. Finally, this paper argued the necessity of developing geographic information analysis models for spatial-contextual classifications using two case studies.
Activities of Key Enzymes in Sucrose-to-Starch Conversion in Wheat Grains Subjected to Water Deficit during Grain Filling1

This study tested the hypothesis that a controlled water deficit during grain filling of wheat (Triticum aestivum) could accelerate grain-filling rate through regulating the key enzymes involved in Suc-to-starch pathway in the grains. Two high lodging-resistant wheat cultivars were field grown. Well-watered and water-deficit (WD) treatments were imposed from 9 DPA until maturity. The WD promoted the reallocation of prefixed 14C from the stems to grains, shortened the grain-filling period, and increased grain-filling rate or starch accumulation rate (SAR) in the grains. Activities of Suc synthase (SuSase), soluble starch synthase (SSS), and starch branching enzyme (SBE) in the grains were substantially enhanced by WD and positively correlated with the SAR. ADP Glc pyrophosphorylase activity was also enhanced in WD grains initially and correlated with SAR with a smaller coefficient. Activities of granule-bound starch synthase and soluble and insoluble acid invertase in the grains were less affected by WD. Abscisic acid (ABA) content in the grains was remarkably enhanced by WD and very significantly correlated with activities of SuSase, SSS, and SBE. Application of ABA on well-watered plants showed similar results as those by WD. Spraying with fluridone, an ABA synthesis inhibitor, had the opposite effect. The results suggest that increased grain-filling rate is mainly attributed to the enhanced sink activity by regulating key enzymes involved in Suc-to-starch conversion, especially SuSase, SSS, and SBE, in wheat grains when subjected to a mild water deficit during grain filling, and ABA plays a vital role in the regulation of this process.
Brazilian version of the Functional Assessment Measure: cross-cultural adaptation and reliability evaluation

The objective of this prospective study was to perform a cross-cultural adaptation of the Functional Assessment Measure (FAM) into Brazilian Portuguese, and to assess the test–retest reliability. The instrument was translated, back-translated, pretested, and reviewed by a committee. The Brazilian version was assessed in 61 brain-injury patients. Intrarater and interrater reliability was verified by a test–retest procedure (intraclass correlation). Intrarater reliability was moderate-to-excellent; interrater reliability was moderate-to-excellent, with the exception of one item. The Brazilian version of the FAM has acceptable test–retest reliability. Results suggest the use of the Brazilian version of the FAM in the Brazilian population, for disability evaluation and outcome assessment. Further research is required to evaluate the psychometric properties of the scale.
Using emotional literacy to improve pedagogical confidence: initial findings from a STEM project

This paper reports on the initial research findings from a multi-institutional STEM project (the Project: It’s Part of MY Life) focused on improving the scientific and mathematical thinking of pre-service teachers (PSTs) by enhancing their pedagogical confidence via improved emotional literacy. This report details how the Project trials have utilised enhanced emotional feedback to enable PSTs to analyse, understand and make use of emotional information to improve their teaching confidence and teaching competence. The report discusses emotional literacy and emotional regulation as aspects of self-reflective professional development, how affect measures were constructed for the project, and how these measures are conceptually related to improving competence and confidence for pre-service STEM teachers. An overview of the research methods designed to connect emotional literacy to the Project goals is also provided, and recommendations made for ongoing research within the project parametres.
Gaining Control: A New Perspective on the Parenting of Children with AD/HD

This qualitative research explored parents’ perspectives of parenting a child with AD/HD-Combined subtype (CT) who was unmedicated. Sixteen parents were interviewed twice and two parents were interviewed once. Data were analysed using grounded theory methods. Findings indicated that parents’ perspectives were primarily concerned with trying to control their child’s difficult behaviours. The substantive theory of Gaining Control that emerged explains the processes that parents used to try to control these behaviours. Two parental controlling/coping pathways were identified. An emotional pathway was associated with negative parental behaviours, poor outcomes, and high distress. The cognitive pathway was associated with surprisingly positive outcomes and low levels of distress. Important outcomes identified included achieving a positive cooperative relationship and highly elevated volitional performance. Processes and subprocesses are described and explained in detail. These findings may have significant clinical and educational implications for enhancing outcomes for the parents and their child.
The KNOTTIN website and database: a new information system dedicated to the knottin scaffold

The KNOTTIN website and database organize information about knottins or inhibitor cystine knots, small disulfide-rich proteins with a knotted topology. Thanks to their small size and high stability, knottins provide appealing scaffolds for protein engineering and drug design. Static pages present the main historical and recent results about knottin discoveries, sequences, structures, folding, functions, applications and bibliography. Database searches provide dynamically generated tabular reports or sequence alignments for knottin three-dimensional structures or sequences. BLAST/HMM searches are also available. A simple nomenclature, based on loop lengths between cysteines, is proposed and is complemented by a uniform numbering scheme. This standardization is applied to all knottin structures in the database, facilitating comparisons. Renumbered and structurally fitted knottin PDB files are available for download. The standardized numbering is used for automatic drawing of two-dimensional Colliers de Perles. The KNOTTIN website and database are available at http://knottin.cbs. cnrs.fr and http://knottin.com.
GTP hydrolysis by complexes of the signal recognition particle and the signal recognition particle receptor

Translocation of proteins across the endoplasmic reticulum membrane is a GTP-dependent process. The signal recognition particle (SRP) and the SRP receptor both contain subunits with GTP binding domains. One GTP- dependent reaction during protein translocation is the SRP receptor- mediated dissociation of SRP from the signal sequence of a nascent polypeptide. Here, we have assayed the SRP and the SRP receptor for GTP binding and hydrolysis activities. GTP hydrolysis by SRP was not detected, so the maximal GTP hydrolysis rate for SRP was estimated to be < 0.002 mol GTP hydrolyzed x mol of SRP-1 x min-1. The intrinsic GTP hydrolysis activity of the SRP receptor ranged between 0.02 and 0.04 mol GTP hydrolyzed x mol of SRP receptor-1 x min-1. A 40-fold enhancement of GTP hydrolysis activity relative to that observed for the SRP receptor alone was obtained when complexes were formed between SRP and the SRP receptor. GTP hydrolysis activity was inhibited by GDP, but not by ATP. Extended incubation of the SRP or the SRP receptor with GTP resulted in substoichiometric quantities of protein-bound ribonucleotide. SRP-SRP receptor complexes engaged in GTP hydrolysis were found to contain a minimum of one bound guanine ribonucleotide per SRP-SRP receptor complex. We conclude that the GTP hydrolysis activity described here is indicative of one of the GTPase cycles that occur during protein translocation across the endoplasmic reticulum.
Intervention of Collective Exercise on the Mental Health of Elderly Hypertensive Patients

Background: Anxiety, depression, and other adverse psychological reactions are often observed in elderly hypertensive patients. Appropriate exercise is a safe form of adjuvant therapy without causing side effects among these patients, with consistent effects on patients’ mental health. In this study, a collective exercise intervention experiment was conducted to evaluate the mental health of elderly hypertensive patients and to verify the effect of the psychological intervention of collective exercise. Method: A total of 115 elderly hypertensive patients aged 60–70 years old were selected as study subjects from May 2012 to January 2015 in Fuzhou City, Fujian Province, China. A total of 57 patients were included in the control group and 58 patients were assigned in the experimental group. Patients in the experimental group participated in a 12 weeks exercise intervention, while patients in the control group didn’t participate in any regular physical exercise. Results: After intervention, the Symptom Checklist-90 (SCL-90), total score, somatization, obsessive-compulsive symptom, interpersonal sensitivity, depression, anxiety, hostility, and paranoia scores of the experimental group were significantly lower than those of the control group (P < 0.05). The positive coping style score of the experimental group was significantly higher than that of the control group (P<0.05); by contrast, the negative coping style score of the experimental group was significantly lower than that of the control group (P < 0.05). Conclusion: The mental health level and coping ability of elderly hypertensive patients can be effectively improved with the proposed treatment.
Boosting multi-kernel locality-sensitive hashing for scalable image retrieval

Similarity search is a key challenge for multimedia retrieval applications where data are usually represented in high-dimensional space. Among various algorithms proposed for similarity search in high-dimensional space, Locality-Sensitive Hashing (LSH) is the most popular one, which recently has been extended to Kernelized Locality-Sensitive Hashing (KLSH) by exploiting kernel similarity for better retrieval efficacy. Typically, KLSH works only with a single kernel, which is often limited in real-world multimedia applications, where data may originate from multiple resources or can be represented in several different forms. For example, in content-based multimedia retrieval, a variety of features can be extracted to represent contents of an image. To overcome the limitation of regular KLSH, we propose a novel Boosting Multi-Kernel Locality-Sensitive Hashing (BMKLSH) scheme that significantly boosts the retrieval performance of KLSH by making use of multiple kernels. We conduct extensive experiments for large-scale content-based image retrieval, in which encouraging results show that the proposed method outperforms the state-of-the-art techniques.
Improving The Mathematic Critical And Creative Thinking Skills In Grade 10th SMA Negeri 1 Kasihan Bantul On Mathematics Learning Through Problem-Based Learning

This research aims to describe: (1) implementation of the PBL that improve the mathematic critical and creative thinking skills and (2) improvement the mathematic critical and creative thinking skills of students with PBL. The research is Classroom Action-Research, which is consisted of two cycles. The research was conducted in SMA Negeri 1 Kasihan Bantul in August until December 2010. The subjects were all of the students in class X D which consist of 33 students. The data was obtained from observation sheet, field notes, documentation, interviews, and tests of critical and creative thinking skills in mathematics learning. The data validation has done by triangulation. The results shows that the implementation of the PBL which can improve the students’ mathematics critical and creative thinking skills consist of four steps: (1) engagement, (2) inquiry and investigation, (3) performance, and (4) debriefing. Keyword: critical thinking, creative thinking, problem based learning
Interactive Rendering of Dynamic Geometry

Fluid simulations typically produce complex three-dimensional (3D) isosurfaces whose geometry and topology change over time. The standard way of representing such "dynamic geometry" is by a set of isosurfaces that are extracted individually at certain time steps. An alternative strategy is to represent the whole sequence as a four-dimensional (4D) tetrahedral mesh. The isosurface at a specific time step can then be computed by intersecting the tetrahedral mesh with a 3D hyperplane. This not only allows the animation of the surface continuously over time without having to worry about the topological changes, but also enables simplification algorithms to exploit temporal coherence. We show how to interactively render such 4D tetrahedral meshes by improving previous GPU-accelerated techniques and building an out-of-core multiresolution structure based on quadric error simplification. As a second application, we apply our framework to time-varying surfaces that result from morphing one triangle mesh into another.
Automatic Text Analysis by Artificial Intelligence

Text is one of the traditional ways of communication between people. With the growing availability of text data in electronic form, handling and analysis of text by means of computers gained popularity. Handling text data with machine learning methods brought interesting challenges to the area that got further extended by incorporation of some natural language specifics. As the methods were capable of addressing more complex problems related to text data, the expectations become bigger calling for more sophisticated methods, in particular a combination of methods from different research areas including information retrieval, machine learning, statistical data analysis, data mining, natural language processing, semantic technologies. Automatic text analysis become an integral part of many systems, pushing boundaries of research capabilities towards what one can refer to as an artificial intelligence dream never ending learning from text aiming at mimicking ways of human learning. The paper presents development of text analysis research in Slovenian that we have been personally involved in, pointing out interesting research problems that have been and are still addressed by the research, example tasks that have been addressed and some challenges on the way.