Miracle-dz/UniFAR-FTUs huggingface dataset:
Microwave radar remote sensing of surface currents in the nearshore region

We present observations of microwave radar backscattered power in the nearshore region, and results of a surface current estimation algorithm using microwave radar data. In low wind and wave conditions, patches of increased backscatter are observed in radar images. Animations of the images show these patches advected by nearshore flows such as wave induced cell circulations and longshore currents
Adrenergic receptors and sensitization of adenylyl cyclase in acute myocardial ischemia.

Acute myocardial ischemia leads to a gradual increase in beta-adrenergic receptors at the cell surface. This increase occurs rapidly after onset of global ischemia (15 minutes) and persists even after prolonged periods of global ischemia. This alteration can be observed both in vivo and in vitro in isolated perfused hearts. Several groups have previously shown that ischemia induces a local release of endogenous catecholamines. Here, we show that these endogenous catecholamines are sufficiently high to induce receptor desensitization with internalization of beta-adrenergic receptors in normal hearts. In acute myocardial ischemia, however, agonist-promoted internalization and functional uncoupling of beta-adrenergic receptors is abolished. Consequently, the balance of internalization and externalization of receptors is shifted toward an increase in functionally coupled receptors at the cell surface. Similarly, but inconsistently, the density of alpha 1-adrenergic receptors in the plasma membrane is increased in acute myocardial ischemia. In regard to function, the increase of coupled beta-adrenergic receptors leads to an augmented responsiveness of the adenylyl cyclase system to beta-adrenergic stimulation. This receptor-specific sensitization is superimposed by a transient increase of total adenylyl cyclase activity in the very early phase of global ischemia (0-20 minutes). The enhanced activity of adenylyl cyclase to direct stimulation is tightly associated with the partially purified enzyme, suggesting a covalent modification of the enzyme molecule. However, after prolonged periods (greater than 30 minutes) of global ischemia, the ischemia-induced enzyme-specific sensitization is displaced by a general reduction in enzyme activity, both in vivo and in vitro. The persistent sensitization at the receptor level then meets an unresponsive adenylyl cyclase. (ABSTRACT TRUNCATED AT 250 WORDS)
Herpes simplex virus type 1 gene products required for DNA replication: identification and overexpression

Seven herpes simplex virus (HSV) genes have been shown recently to be necessary and sufficient to support the replication of origin-containing plasmids. Two of these genes (pol and dbp) encode well-known DNA replication proteins (the DNA polymerase and the major single-stranded DNA binding protein), and a third gene (UL42) encodes a previously identified infected-cell protein which binds tightly to double-stranded DNA. The products of the four remaining genes have not previously been identified. Using the predicted amino acid sequence data (D.J. McGeoch, M.A. Dalrymple, A. Dolan, D. McNab, L.J. Perry, P. Taylor, and M.D. Challberg, J. Virol. 62:444-453; D.J. McGeoch and J.P. Quinn, Nucleic Acids Res. 13:8143-8163), we have raised rabbit antisera against the products of all seven genes. We report here the use of these reagents to identify these proteins in infected cells. All seven proteins localized to the nucleus and were expressed in a manner consistent with the idea that they are the products of early genes. Various immunological assays suggest that four of these proteins (UL5, UL8, UL9, and UL52) are made in infected cells in very low abundance relative to the other three. To improve our ability to study these proteins, we have expressed UL5, UL8, UL9, and UL52 in insect cells by using the baculovirus expression system. The HSV protein made in insect cells were immunoprecipitable with the appropriate antisera, and the size of each protein was indistinguishable from the size of the corresponding protein made in HSV-infected Vero cells. Our data offer strong support for the accuracy of open reading frames proposed by McGeoch et al. In addition, the antisera and the overproduced HSV replication proteins should be useful reagents with which to analyze the biochemistry of HSV DNA replication.
The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations

The remarkable success of immune therapies emphasizes the need for immune‐competent cancer models. Elegant genetically engineered mouse models of a variety of cancers have been established, but their effective use is limited by cost and difficulties in rapidly generating experimental data. Some mouse cancer cell lines are transplantable to immunocompetent host mice and have been utilized extensively to study cancer immunology. Here, we describe the Yale University Mouse Melanoma (YUMM) lines, a comprehensive system of mouse melanoma cell lines that are syngeneic to C57BL/6, have well‐defined human‐relevant driver mutations, and are genomically stable. This will be a useful tool for the study of tumor immunology and genotype‐specific cancer biology.
The Adaptive Stochastic Matched Filter for SAS Images denoising

SAS images are highly corrupted by a granular multiplicative noise, called the speckle which reduces spatial and radiometric resolutions. The purpose of this article is to present a new adaptive processing that allows speckle noise reduction in SAS images, while keeping the spatial resolution. This processing is based on the two-dimensional stochastic matched filtering method with a signal autocorrelation function adaptation and a sub-image size adaptation. Comparison with some classical approaches on real SAS data reveal the efficiency of such an idea
Quantitative computational models of molecular self-assembly in systems biology

Molecular self-assembly is the dominant form of chemical reaction in living systems, yet efforts at systems biology modeling are only beginning to appreciate the need for and challenges to accurate quantitative modeling of self-assembly. Self-assembly reactions are essential to nearly every important process in cell and molecular biology and handling them is thus a necessary step in building comprehensive models of complex cellular systems. They present exceptional challenges, however, to standard methods for simulating complex systems. While the general systems biology world is just beginning to deal with these challenges, there is an extensive literature dealing with them for more specialized self-assembly modeling. This review will examine the challenges of self-assembly modeling, nascent efforts to deal with these challenges in the systems modeling community, and some of the solutions offered in prior work on self-assembly specifically. The review concludes with some consideration of the likely role of self-assembly in the future of complex biological system models more generally.
Dimensions of Product Brand Personality

The success of a brand relies on the extent to which it differentiates itself from the myriad of competitors. As brands seek to become distinctive, brand personality is viewed as a viable metaphor for understanding consumers’ perceptions of brands and for crafting a unique identity in their minds. Measurement and management of brand personality becomes significant in this regard. Most of the existing brand personality scales are either designed to measure the brand personality construct in general or to measure particular categories of brands. There is a lack of a scale which measures the personality of product brands as such. This research tries to fill this lacuna by creating a new product brand personality scale incorporating various advancements in the field of brand personality measurement. This study employs a mixed method approach and the important phases include construct definition, item generation, measure purification, assessment of reliability and validity, and development of a short version of the scale. Findings of this research reconfirm the consumers' tendency to attribute personality characteristics to brands. It also identifies seven dimensions of product brand personality with 26 items.
Characterizing the size and molecular weight distribution of starch: Why it is important and why it is hard

Starch is one of the most important polymers for humanity: It comprises the largest single component of our food energy, and is also an important industrial polymer, for example, it is used in papermaking, biofuels, and the food and pharmaceutical industries as an additive with diverse uses. On one level, it is simple: a polymer of ➤ Starch is the largest component of our food energy and has important industrial applications.
Obstáculos para aprender conceptos elementales de electrostática y propuestas educativas

Este trabajo se centra en los obstaculos y dificultades para aprenden los conceptos basicos de electrostatica. Se han analizado obstaculos conceptuales como dificultades relacionadas con la demanda cognitiva, con las concepciones de los alumnos y con la ensenanza en los libros de texto. De acuerdo con todo ello se proponen estrategias de ensenanza que han sido experimentadas con maestros en formacion inicial.
Cancer Biology and Signal Transduction Nedd 8-Activating Enzyme Inhibitor MLN 4924 Provides Synergy with Mitomycin C through Interactions with ATR , BRCA 1 / BRCA 2 , and Chromatin Dynamics Pathways

MLN4924 is an investigational small-molecule inhibitor of the Nedd8-activating enzyme currently in phase I clinical trials. MLN4924 induces DNA damage via rereplication in most cell lines. This distinct mechanism of DNA damage may affect its ability to combine with standard-of-care agents and may affect the clinical development of MLN4924. As such, we studied its interaction with other DNA-damaging agents. Mitomycin C, cisplatin, cytarabine, UV radiation, SN-38, and gemcitabine demonstrated synergy in combinationwithMLN4924 in vitro. The combination ofmitomycin C andMLN4924was shown to be synergistic in a mouse xenograft model. Importantly, depletion of genes within the ataxia telangiectasia and Rad3 related (ATR) and BRCA1/BRCA2 pathways, chromatin modification, and transcription-coupled repair reduced the synergy between mitomycin C and MLN4924. In addition, comet assay demonstrated increased DNA strand breaks with the combination ofMLN4924 andmitomycin C. Our data suggest that mitomycin C causes stalled replication forks, which when combined with rereplication induced by MLN4924 results in frequent replication fork collisions, leading to cell death. This study provides a straightforward approach to understand the mechanism of synergy, which may provide useful information for the clinical development of these combinations. Mol Cancer Ther; 13(6); 1625–35. 2014 AACR.
Influence of human resource management practices on employee engagement in developing economy

Employee engagement is considered as a vital issue to the practitioners for smooth operations of their business concerns. Thus, the study is conducted to measure the influence of Human Resource Management (HRM) practices as an antecedent of employee engagement. This study collected data from 392 operational level employees through survey method who is working at different garment factories in Bangladesh. The collected data were analyzed through structural equation modeling to partial least square method. The study empirically proves that employee compensation and employee promotion opportunity have significant influence on the employees’ engagement level. This study has both theoretical and practical implications in the context of ready-made garment industry in Bangladesh since employee engagement regarded as comparatively new concept in the developing context. The practitioners and policy makers of the organization are expected to make necessary adjustments in their existing HRM practices on the basis of the results of this model in the context of developing economy like Bangladesh for enhancing the employee engagement level so that their whole-hearted efforts can be ensured for the smooth operations of business.
How Do Consumers Choose Sellers In E-Marketplaces?

ABSTRACT In e-marketplaces, consumers often have to choose a seller from which to purchase a product. The author argues that seller choice depends on both evaluations of the display price of the product, related to anchoring, and sellers' review volume, related to assimilation-contrast. Results of two studies, including an eye-tracking study, show that participants more likely would purchase at the display price from sellers with high review volume. Participants favored buying from high-display-price sellers with high review volume, versus low-display-price sellers with low review volume. This suggests that the display price should be from a seller with relatively higher review volume and emphasizes the importance of review volumes to sellers.
Fibred Computational Effects

Dependent types provide a lightweight and modular means to integrate programming and formal program verification. In particular, the types of programs written in dependently typed programming languages (Agda, Idris, F*, etc.) can be used to express specifications of program correctness. These specifications can vary from being as simple as requiring the divisor in the division function to be non-zero, to as complex as specifying the correctness of compilers of industrial-strength languages. Successful compilation of a program then guarantees that it satisfies its type-based specification. While dependent types allow many runtime errors to be eliminated by rejecting erroneous programs at compile-time, dependently typed languages are yet to gain popularity in the wider programming community. One reason for this is their limited support for computational effects, an integral part of all widely used programming languages, ranging from imperative languages, such as C, to functional languages, such as ML and Haskell. For example, in addition to simply turning their inputs to outputs, programs written in these programming languages can raise exceptions, access computer's memory, communicate over a network, render images on a screen, etc. Therefore, if dependently typed programming languages are to truly live up to their promise of seamlessly integrating programming and formal program verification, we must first understand how to properly account for computational effects in such languages. While there already exists work on this topic, ingredients needed for a comprehensive theory are generally missing. For example, foundations are often not settled; available effects may be limited; or effects may not be treated systematically. In this thesis we address these shortcomings by providing a comprehensive treatment of the combination of dependent types and general computational effects.
The Relationship Between Financial Planner Use and Holding a Retirement Saving Goal: A Propensity Score Matching Analysis

It has been well established in the literature that financial advice leads to informed decision making and improved financial outcomes. However, there is limited evidence regarding the link between financial planner use and attitudes towards retirement saving. As financial planners provide comprehensive advice for the long-term benefits of clients, their clients may become more aware of retirement saving as an important goal. We used data from the 2010 and 2013 Survey of Consumer Finances to examine the association between financial planner use and setting a retirement saving goal. We found that households who consulted a financial planner were more likely to report retirement as the motive for saving, even after we employed a propensity score matching technique to account for systematic differences between those who used and did not use financial planners. Our findings suggest that financial planners do help individuals achieve their long-term financial objectives by highlighting the importance of retirement planning. The use of other types of financial professionals was not positively associated with the likelihood of setting retirement as an important saving goal in our main model.
Influence of Different Thicknesses on Mechanical and Corrosion Properties of α-C:H Films

: The hydrogenated amorphous carbon films (a-C:H) were deposited on p-type Si (100) substrates at different thicknesses by radio frequency plasma enhanced chemical vapor deposition technique (rf-PECVD). Raman spectra display asymmetric diamond-like peaks, representative of the a-C:H films. The decrease of intensity ID/IG ratios revealed the sp3 content arise at different thicknesses of the a-C:H films. In terms of mechanical properties, the high hardness and elastic modulus values show the elastic and plastic deformation behaviors related to sp3 content in amorphous carbon films. Electro chemical properties showed that the a-C:H films exhibited excellent corrosion resistance in air-saturated 3.5 wt% NaCl solution for pH 2 at room temperature. Thickness increasing affected the small sp2 clusters in matrix, restricting the velocity transfer and exchange of electrons. The deposited a-C:H films exhibited excellent mechanical properties and corrosion resistance.
Modelling the spatial accessibility of the elderly to healthcare services in Beijing, China

In the context of rapid population aging, Beijing is facing great challenges in providing healthcare services for the elderly. The objective of this study is to measure the spatial accessibility of the elderly to healthcare services in Beijing. A major challenge is that healthcare services are not exclusive for the elderly, so the elderly must compete with the non-elderly for access to healthcare services. In this study, we have developed a multi-mode and variable-demand two-step floating catchment area model for measuring spatial accessibility of the elderly to healthcare services, taking into account the competition between the elderly and non-elderly. This is modeled by differences in demand intensity and mobility. The elderly have a higher demand intensity and are disadvantaged in mobility due to their higher dependence on public transportation than the non-elderly. To improve the elderly’s healthcare accessibility, more healthcare resources should be allocated and the public transportation to hospitals should be improved, especially in peripheral areas. The proposed model can also be applied in other scenarios considering multiple population groups with different demand intensity for public services and mobility.
Green Halal Supply Chain in Malaysian Halal Food Companies: A Conceptual Framework

The aim of becoming a global Halal hub has been outlined in the Third Industrial Master Plan 2006–2020 (IMP3) and Malaysia now is on target to attain the status by 2020. However, the progression needs to be geared with a holistic ecosystem that enable closing compliance loop within Halal supply chain. Thus, calling for sustainable development to strengthen the Halal definition. Despite the urge, the degree of readiness to employ green practices in Halal food industry is still vague and the issues are still new and developing. Food industry is one of the major contributors to environmental problems, large amount of waste is generated from food industry, by promoting sustainability in producing Halal food can reduce their environmental footprint and will benefit Malaysia where other countries can recognize Malaysian Halal standards not only for hygiene and safety but also as a symbol of eco-friendly practices. Therefore, green Halal supply chain is now seen to be central towards global Halal hub. Responding to these needs, this study is expected; (1) to identify what are the green practices implemented in collaboration with supplier and customer in managing Halal food supply chain (2) to assess what is sustainable performance achieved from green practices implemented (3) to determine if supplier-customer collaboration moderates the impact of green practices on sustainable performance. This study will employ mixed methods of qualitative and quantitative to answer the study’s objectives. Overall, this study is expected to present a model that provides a comprehensive view on Green Halal supply chain concerning supplier-customer collaboration in green practices. The model can help the industry and policy maker to identify what green practices are feasible to collaborate with and what are the related benefits and barriers. Engaging Green Halal Supply Chain can further improve Malaysian reputation as the world’s leading Halal hub.
Grassroots Market Research on Grass: Predicting Cannabis Brand Performance Using Social Media Scraping

Social media listening has become a useful tool to marketers in studying behavior for a wide variety of consumer applications, from political leanings and drug abuse to common product choices. Although most cannabis products are illegal at the U.S. Federal level, it is legal in 30 states for medical use and 8 states and the District of Columbia for recreational use. Despite the legal issues, cannabis is projected to reach over $31 billion in sales world-wide by 2021. The industry is both rapidly evolving and highly fragmented, making it challenging for companies operating in the space to access the insights and the data to help design communications, product development and branding strategies. The research presented here will show that the application of social media listening can be helpful for cannabis brand marketers to gauge size, scope and nuances of these markets and tailored social media mining can accurately predict a brand’s future performance. Later research will show that social media scraping will help identify and segment consumers at a fraction the cost of traditional consumer research methods.
Epidemiology and Molecular Analysis of Intestinal Colonization by Vancomycin-Resistant Enterococci in Greek Hospitals

ABSTRACT From 1,246 specimens collected from 13 Greek hospitals, 266 vancomycin-resistant enterococci strains were isolated from 255 patients (20.5%). The VanA phenotype was present in 82 (30.8%) strains, the VanB phenotype in 17 (6.4%) strains, the VanC1 phenotype in 152 (57.1%) strains, and the VanC2/C3 phenotypes in 15 (5.6%) strains. When only VanA and VanB phenotypes were considered, the overall prevalence was 7.5%. Eighty-six isolates exhibiting the VanA or VanB phenotype were analyzed by pulsed-field gel electrophoresis (PFGE), and 46 PFGE groups were found.
A Mutual Information Approach for Comparing LLR Metrics for Iterative Decoders

We develop an approach to compare different log-likelihood ratio (LLR) metrics for iterative soft decoding. We show that an LLR metric for a function of the received signals is a sufficient statistic to this function about the binary channel input. We also prove that when the function belongs to a set of specific mappings, the corresponding LLR metric can feed the maximal mutual information to the decoder. For decoding low density parity check codes with the belief-propagation decoder, we develop a method to estimate the minimal average number of iterations. The results are applied to compare the Gaussian metric in [1] and the two-symbol-observation-interval LLR metric in [2]. The latter is shown to be superior.