Miracle-dz/UniFAR-FTUs huggingface dataset:
Material para o ensino do cálculo diferencial e integral: referências de Tall, Gueudet e Trouche

Esta tese apresenta um material para o ensino de Calculo Diferencial e Integral composto por sete atividades que foram embasadas em referenciais teoricos da Educacao Matematica. Nelas, foram abordados os conceitos de funcao, continuidade, diferenciabilidade, solucao de uma equacao diferencial, integral e limite de sequencias. Pretendeu-se defender que uma das formas de se estabelecer o estreitamento da relacao teoria e pratica nessa area de investigacao e feita por meio de elaboracao de materiais para o ensino com essa finalidade. Foram utilizadas as nocoes de organizador generico, raiz cognitiva e Tres Mundos da Matematica de Tall e colaboradores, e a nocao de recurso da Genese Documental de Gueudet e Trouche. O uso do computador e a construcao de ferramentas no GeoGebra foram procedimentos ferteis para se obter um material com as competencias planejadas. A pesquisa, que teve por resultado o material para o ensino, seguiu orientacao metodologica de uma do tipo pesquisa fundamental, na qual se objetiva o preenchimento de lacunas no conhecimento relativo a solucao de problemas advindos da pratica. Adotou-se uma postura teorica exploratoria, a da construcao de argumentos com rigor e coerencia logica para validar os resultados obtidos. Nesse âmbito de referenciais teorico- metodologicos, foram elaboradas sete atividades para o ensino de Calculo, organizadas em tres componentes, as quais compoem um recurso (matematica, material e didatica) na concepcao da Genese Documental, incorporando nocoes cognitivistas de Tall e seus associados. A utilizacao das componentes (matematica, material e didatica) possibilita que o material possa se configurar em um elemento do conjunto de recursos, conforme a Genese Documental, de um professor de Calculo, para o desenvolvimento de uma aula. Como resultado pode-se demonstrar que o modo de elaboracao proposto para um material para o ensino, em que se incorporam teorias da Educacao Matematica e se utiliza um software adequado, pode ser um meio potente para favorecer a integracao teoria e pratica, almejada e necessaria pela Educacao Matematica, alem de contribuir com a aprendizagem
Differential Regulation of the Catalytic and Accessory Subunit Genes of Drosophila Mitochondrial DNA Polymerase*

The developmental pattern of expression of the genes encoding the catalytic (α) and accessory (β) subunits of mitochondrial DNA polymerase (pol γ) has been examined inDrosophila melanogaster. The steady-state level of pol γ-β mRNA increases during the first hours of development, reaching its maximum value at the start of mtDNA replication inDrosophila embryos. In contrast, the steady-state level of pol γ-α mRNA decreases as development proceeds and is low in stages of active mtDNA replication. This difference in mRNA abundance results at least in part from differences in the rates of mRNA synthesis. The pol γ genes are located in a compact cluster of five genes that contains three promoter regions (P1–P3). The P1 region directs divergent transcription of the pol γ-β gene and the adjacent rpII33 gene. P1 contains a DNA replication-related element (DRE) that is essential for pol γ-β promoter activity, but not for rpII33 promoter activity in Schneider's cells. A second divergent promoter region (P2) controls the expression of theorc5 and sop2 genes. The P2 region contains two DREs that are essential for orc5 promoter activity, but not for sop2 promoter activity. The expression of the pol γ-α gene is directed by P3, a weak promoter that does not contain DREs. Electrophoretic mobility shift experiments demonstrate that the DRE-binding factor (DREF) regulatory protein binds to the DREs in P1 and P2. DREF regulates the expression of several genes encoding key factors involved in nuclear DNA replication. Its role in controlling the expression of the pol γ-β and orc5genes establishes a common regulatory mechanism linking nuclear and mitochondrial DNA replication. Overall, our results suggest that the accessory subunit of mtDNA polymerase plays an important role in the control of mtDNA replication in Drosophila.
The Pseudomonas-Achromobacter group.

Fifty-three strains of nonpigmented Gram-negative rods which failed to produce acid in Kligler's iron agar were studied. Detailed examination revealed that many strains had been incorrectly identified as Alcaligenes. Sixteen strains were identified as Pseudomonas aeruginosa, and it was concluded that important identifying characteristics of this species are: (1) acid production from glucose, arabinose, and xylose, but not from lactose; (2) the ability to liquefy gelatin; (3) good motility and production of gaseous nitrogen in a motility–nitrate medium; and (4) a positive gluconate test. Thirty-seven strains appeared to be members of the genus Achromobacter and all produced acid from one or more carbohydrates. These strains were divided into three groups on the basis of (1) activity on gelatin, (2) nitrate reduction, and (3) motility. Some strains resembled Pseudomonas aeruginosa in such characteristics as reduction of nitrate to molecular nitrogen and oxidation of gluconate to 2-ketogluconate, but differe.
High-resolution imaging of lowermost mantle structure under the Cocos plate

[1] Broadband seismic shear waves are analyzed to investigate the fine-velocity structure in the lowermost mantle beneath the Cocos plate, a region where previous studies have indicated the presence of a shear velocity increase about 200–300 km above the core-mantle boundary. Data from 14 South American earthquakes recorded at California broadband networks provide dense ray path sampling of the lowermost mantle in an approximately 700 km long north-south corridor, roughly 150 km wide. Application of a simplified seismic migration method that uses a homogeneous background velocity model suggests topography of the previously imaged positive impedance jump, varying in depth from north to south by as much as 150 km, with a weakly reflecting transition zone in between. The migration approach enables examination of small-scale spatial variations and out-of-plane scattering effects. Topography of the discontinuity may account for observed variations in the amplitude of reflected arrivals or there may be lateral variations in the velocity contrast across the boundary. Lateral variations of the shear velocity structure within the D″ layer may produce some apparent topography in the discontinuity image, but any such volumetric structure is not yet well enough determined to incorporate in the migration. A localized negative impedance contrast reflector or scatterer is imaged at depths about 100 km below the positive reflector in the northern portion of the study area. Several scenarios can explain these results, including (1) a slab that reaches the lowermost mantle, (2) the birth of an upwelling beneath a recumbent slab, or (3) chemical layering in this region.
Renal-artery pseudoaneurysm after laparoscopic partial nephrectomy.

BACKGROUND AND PURPOSE Laparoscopic partial nephrectomy (LPN) has emerged as a minimally invasive treatment for small renal masses. The most common complications include hemorrhage and urinary-fistula formulation. Renal-artery pseudoaneurysm has been described after open nephron-sparing surgery. We present two cases of renal-artery aneurysm following LPN. CASE REPORTS Two patients with incidentally discovered renal masses underwent LPN with excellent hemostasis and presented in a delayed fashion with gross hematuria and flank pain. Both patients were treated with angiographic coil embolization, resulting in resolution of the pseudoaneurysms on postprocedure imaging. CONCLUSIONS Renal-artery pseudoaneurysm is a potentially life-threatening complication of LPN. Patients present in a delayed fashion with gross hematuria, flank pain, or both. The treatment of choice is angiography with selective coil embolization.
The Future of Smart Photography

The field of image and video recognition is quickly progressing, with new technology now allowing for content-based search and classification of digital media. This article introduces the area of smart photography (automatically improving or modifying an image based on visual concept detection, performed entirely on the camera in real time) and describes the Impala app, a real-world application developed by Euvision Technologies.
Text segmentation using superpixel clustering

Text segmentation is important for text image analysis and recognition; however, it is challenging due to noise and complex background in natural scenes. Superpixel-based image representation can enhance robustness to noise and local disturbances, but conventional superpixel algorithms are difficult to obtain the complete stroke regions and accurate boundaries for text images. In this study, a text segmentation method based on superpixel clustering is proposed. First, to generate accurate superpixels for text images, an adaptive simple linear iterative clustering-based text superpixel generation algorithm is proposed. The adaptive superpixel size and compactness are calculated to enhance boundary adherence. Second, to increase the complete coverage of strokes from superpixels, superpixel clustering merges homogeneous superpixels into larger regions for both strokes and the background. A modified density-based spatial clustering of applications with noise is proposed. Finally, stroke superpixel verification assigns each region to a stroke or to the background and the text segmentation result is obtained. The proposed method shows promising robustness to noise and complex background textures. Experimental results on the Korea Advanced Institute of Science and Technology (KAIST) scene text dataset, International Conference on Document Analysis and Recognition (ICDAR) 2003 natural scene text image dataset and Street View Text dataset verify that this method is effective and significantly outperforms existing methods.
Estimation des pertes dans les transistors bipolaires SiC

Cet article traite de l'estimation des pertes dans les transistors bipolaire SiC. Deux methodes sont presentees ici. La premiere, qualifiee d'electrique, consiste a mesurer la tension et le courant commutes par le composant puis de calculer les pertes par conduction et par commutation (amorcage et blocage indifferencies). Cette methode de mesure, tres sensible, est ensuite comparee a la deuxieme methode dite methode calorimetrique. Cette derniere simplifiee ici consiste a mesurer l'elevation de temperature d'un bloc d'aluminium sur lequel le transistor est monte. Connaissant la capacite thermique du bloc d'aluminium, il est ensuite possible de calculer les pertes totales dans le transistor pourvu (les echanges thermiques avec l'exterieur sont negliges pour le calcul). La faible difference de resultats valide la methode electrique qui, combinee a la methode de la double impulsion, permet l'etude de differents parametres environnants (courant de base, courant de collecteur, diode anti-saturation, temperature de jonction.) pour une temperature de jonction quasi-constante.
Evaluation of Pulmonary Function After Radiotherapy Using Helical Tomotherapy for Breast Cancer Treatment: Prospective Study

Accessible online at: www.onkder. org 1Department of Radiation Oncology, Dicle University Faculty of Medicine, Diyarbakır-Turkey 2Department of Pulmonary Diseases, Dicle University Faculty of Medicine, Diyarbakır-Turkey 3Department of Family Medicine, Dicle University Faculty of Medicine, Diyarbakır-Turkey 4Department of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakır-Turkey 5Department of Radiology, Dicle University Faculty of Medicine, Diyarbakır-Turkey
Principles and practice of antibiotic therapy of diabetic foot infections

Foot infections are a common and serious problem in diabetic patients. They usually occur as a consequence of a skin ulceration, which initially is colonized with normal flora, and later infected with pathogens. Infection is defined clinically by evidence of inflammation, and appropriate cultures can determine the microbial etiology. Aerobic gram‐positive cocci are the most important pathogens; in chronic, complex or previously treated wounds, gram‐negative bacilli and anaerobes may join in a polymicrobial infection. In all diabetic foot infections a primary consideration is whether or not surgical intervention is required, e.g. for undrained pus, wound debridement or revascularization. Antibiotic regimens are usually selected empirically initially, then modified if needed based on results of culture and sensitivity tests and the patient's clinical response. Initial therapy, especially in serious infections, may need to be broad‐spectrum, but definitive therapy can often be more targeted. Severe infections usually require intravenous therapy initially, but milder cases can be treated with oral agents. Treatment duration ranges from 1–2 weeks (for mild soft tissue infection) to more than 6 weeks (for osteomyelitis). The choice of a specific agent should be based on the usual microbiology of these infections, data from published clinical trials, the severity of the patient's infection, and the culture results. Extension of infection into underlying bone can be difficult to diagnose and may require imaging tests, e.g. magnetic resonance scans. Cure of osteomyelitis usually requires resection of infected bone, but can be accomplished with prolonged antibiotic therapy. Various non‐antimicrobial adjunct therapies may sometimes be helpful. Published in 2000 by John Wiley & Sons, Ltd.
First Genome Sequences of Dengue Virus Strains Isolated during the First DENV-4 Outbreak in São Paulo, Brazil

ABSTRACT Dengue virus (DENV) is an arbovirus belonging to the genus Flavivirus, family Flaviviridae. In Brazil, the reemergence and spread of DENV type 4 (DENV-4) across the country were responsible for a significant outbreak in Guarujá, São Paulo, Brazil. Here, we report the first genomic sequences of DENV strains circulating in Guarujá during the 2013 outbreak.
Modélisation numérique et physique de la chaîne de récupération de l'énergie de la houle par un dispositif bord à quai

Ce memoire presente l’etude du comportement d’un flotteur bord a quai. Ce flotteur est constitued’une bouee de section rectangulaire situee a proximite d’une digue verticale. Un modele analytique lineaire base sur la theorie de l’ecoulement potentiel est realise en profondeur d’eau intermediaire. Un modele numerique resolvant les equations de Navier-Stockes est developpe. Des essais experimentaux sont egalement mis au point pour des flotteurs de differentes dimensions et servent de references aux deux autres modeles. La comparaison de ces trois modeles permet de deduire le domaine de validite du modele analytique, ainsi que la presence d’effets non-lineaires agissant sur le comportement du flotteur.Dans un premier temps, l’impact des dimensions du systeme sur le comportement du flotteur est quantifie. Les effets non-lineaires sont quantifies en fonction des grandeurs du systeme puis une correction du modele analytique est proposee. Par la suite, la correction du modele est appliquee au comportement du systeme incluant un recuperateur d’energie.Dans un second temps, l’effet du flotteur sur les franchissements de digue est etudie. Les franchissements de digue sont exprimes grâce a la hauteur de houle entre la digue et le flotteur (exprimee par le modele analytique) et a la formule de Van Der Meer (2002). Ces franchissements sont egalement estimes de maniere experimentale. Il est montre que lorsque la longueur d’onde de la houle est importante et que le degagement entre la digue et le flotteur est faible, les franchissements de digue sont reduits par la presence du flotteur.
Two classes of region III flagellar genes in Escherichia coli

We infected various nonflagellated mutants of Escherichia coli with fla-transducing phages and followed the kinetics of the appearance of motility. Our analysis revealed two distinct classes of region III fla genes. Class II fla genes (hag, flaD) functioned 15 min later than class I fla genes (flaN, flaB, flaC, flaO, flaA, flbD, flaQ, flaP) in flagellar morphogenesis. We suggest that the two classes of fla genes are involved in two different stages, initiation (class I) and completion (class II), of flagellar formation.
Thermal Activation of CuBTC MOF for CO Oxidation: The Effect of Activation Atmosphere

High performance catalysts for carbon monoxide (CO) oxidation were obtained through thermal activation of a CuBTC (BTC: 1,3,5-benzenetricarboxylic acid) metal–organic framework (MOF) in various atmospheres. X-ray diffraction (XRD), X-ray photonelectron spectroscopy (XPS), N2 adsorption–desorption measurement, and field emission scanning electron microscopy (FESEM) were adopted to characterize the catalysts. The results show that thermal activation by reductive H2 may greatly destroy the structure of CuBTC. Inert Ar gas has a weak influence on the structure of CuBTC. Therefore, these two catalysts exhibit low CO oxidation activity. Activating with O2 is effective for CuBTC catalysts, since active CuO species may be obtained due to the slight collapse of CuBTC structure. The highest activity is obtained when activating with CO reaction gas, since many pores and more effective Cu2O is formed during the thermal activation process. These results show that the structure and chemical state of coordinated metallic ions in MOFs are adjustable by controlling the activation conditions. This work provides an effective method for designing and fabricating high performance catalysts for CO oxidation based on MOFs.
Emerging directions in predictive text mining

In recent years, Text Mining has seen a tremendous spurt of growth as data scientists focus their attention on analyzing unstructured data. The main drivers for this growth have been big data as well as complex applications where the information in the text is often combined with other kinds of information in building predictive models. These applications require highly efficient and scalable algorithms to meet the overall performance demands. In this context, six main directions are identified where research in text mining is heading: Deep Learning, Topic Models, Graphical Modeling, Summarization, Sentiment Analysis, Learning from Unlabeled Text. Each direction has its own motivations and goals. There is some overlap of concepts because of the common themes of text and prediction. The predictive models involved are typically ones that involve meta‐information or tags that could be added to the text. These tags can then be used in other text processing tasks such as information extraction. While the boundary between the fields of Text Mining and Natural Language Processing is becoming increasingly blurry, the importance of predictive models for various applications involving text means there is still substantial growth potential within the traditional sub‐fields of text mining. These data‐centric directions are also likely to influence future research in Natural Language Processing, especially in resource‐poor languages and in multilingual texts. WIREs Data Mining Knowl Discov 2015, 5:155–164. doi: 10.1002/widm.1154
Psychological Distress and Coping Strategies among Parents of Beta-Thalassemia Major Patients

β-Thalassemia major is a disorder characterized by defective production of hemoglobin and excessive destruction of red blood cells. The usual treatment consists of periodic blood transfusions that can cause iron overload within tissues. Parents of thalassemic patients not only have concerns regarding their children’s goal, expectation and standard of life but, also the impact of diagnosis and treatment on family stability and family dynamics. The present study focuses on psychological well being of parents of thalassemic patients.
Association of HIV-1 Replication Capacity With Treatment Outcomes in Patients With Virologic Treatment Failure

Background:The extent to which HIV-1 replication capacity (RC) influences the response to therapy remains to be established. Methods:Phenotypic susceptibility and RC of baseline isolates (n = 139) from patients enrolled in the ARGENTA trial were measured and correlated to treatment outcomes over 36 months. Results:RC in baseline isolates correlated with the number of phenotypically active drugs (R = 0.34, P < 0.001). Crude viral RC did not predict treatment outcomes. When viral RC was adjusted by baseline CD4 cell counts, HIV-1 RNA levels, and phenotypic susceptibility to the rescue regimen, it showed significant association with the immunologic outcome (per log10 RC higher, mean difference in 36 months' time-averaged change from baseline CD4 count = −68 cells/μL; P = 0.020). In the subgroup of patients with 3 or more phenotypically active drugs in the salvage regimen (n = 35, median RC = 65%), subjects carrying isolates with RC ≤65% as compared to those with RC >65% had better time-averaged HIV-1 RNA responses (mean: −1.04 vs. −0.32 log10 copies/mL; P = 0.012) and CD4 cell responses (mean: 132 vs. −7 cells/μL; P = 0.006). Among patients with HIV-1 RNA levels persistently >500 copies/mL (n = 61), RC, on a log10 basis, was inversely associated with time-averaged 36-month CD4 cell responses (β = −0.26; P = 0.046). Conclusion:After normalizing for viral susceptibility to the employed regimen or in patient subsets with suboptimal virologic response, higher viral RC may predict worse subsequent treatment outcomes.
On The Syntax of Subjects in Brazilian Portuguese: Using the ‘SPLIT' Pronominal Sytem as the Basis for an Alternative Analysis

O objetivo deste artigo e investigar a sintaxe do Portugues Brasileiro (PB), desenvolvendo uma proposta unifcada para os casos de oracoes com sujeitos referenciais e nao-referenciais, por um lado, e de oracoes do tipo topico-sujeito, com ordem VS, com sujeito de terceira pessoa e interpretacao generica sem o pronome ‘se', com verbos existenciais e meteorologicos, em que, por hipotese, a posicao de sujeito e preenchida por um sintagma locativo (temporal/ espacial) manifesto ou nulo. Por hipotese, nesses contextos, o sujeito e preenchido por um DP/ pronome (nulo ou manifesto) com interpretacao locativa (espacial/ temporal). Argumentamos que e possivel entender os fatos relevantes se analisarmos o sistema pronominal/i¬‚exional do PB como sendo cindido em dois subsistemas: um, composto pela primeira e segunda pessoas, que sao inerentemente defnidas/referenciais; e o outro, constituido pela terceira pessoa, que e subespecifcada para o traco defnido/referencial. A proposta que defendemos e que a divisao desse sistema pronominal/i¬‚exional constitui a chave para explicar a distribuicao de sujeitos locativos (espaciais/temporais) manifestos e de sujeitos nulos de terceira pessoa em PB, tanto em oracao matriz como em oracao encaixada. Na discussao, apresentamos uma retrospectiva das analises mais representativas sobre a sintaxe do sujeito (manifesto e nulo) no PB, ressaltando que a falta de consenso em sua implementacao teorica decorre dos recortes teoricos adotados (os quais sao muitas vezes complementares), embora as contribuicoes sejam convergentes em relacao as propriedades da terceira pessoa e ao papel da orientacao para o discurso, o que respalda a unifcacao presentemente proposta.
Inhibition of in vitro enzymatic DNA amplification reaction by ultra-violet light irradiation.

Ultra-violet light irradiation of containers and components used in in vitro DNA amplification reactions catalyse by Taq DNA polymerase is a simple and effective method to reduce carry-over contamination and can reduce false-positive results. However, we found that prolonged exposure of water in polypropylene microcentrifuge tubes to u.v. light can result in reduction of amplification efficiency by at least two orders of magnitude when these water specimens are used in amplification reaction mixtures. Although the mechanism that causes this inhibition of DNA amplification is unclear now, the results seem to suggest that u.v. irradiation for routine anti-contamination purposes should be used with caution.