Miracle-dz/UniFAR-FTUs huggingface dataset:
Transforming the Premier Perspective® Hospital Database into the Observational Medical Outcomes Partnership (OMOP) Common Data Model

Background: The Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) has been implemented on various claims and electronic health record (EHR) databases, but has not been applied to a hospital transactional database. This study addresses the implementation of the OMOP CDM on the U.S. Premier Hospital database. Methods: We designed and implemented an extract, transform, load (ETL) process to convert the Premier hospital database into the OMOP CDM. Standard charge codes in Premier were mapped between the OMOP version 4.0 Vocabulary and standard charge descriptions. Visit logic was added to impute the visit dates. We tested the conversion by replicating a published study using the raw and transformed databases. The Premier hospital database was compared to a claims database, in regard to prevalence of disease. Findings: The data transformed into the CDM resulted in 1% of the data being discarded due to data errors in the raw data. A total of 91.4% of Premier standard charge codes were mapped successfully to a standard vocabulary. The results of the replication study resulted in a similar distribution of patient characteristics. The comparison to the claims data yields notable similarities and differences amongst conditions represented in both databases. Discussion: The transformation of the Premier database into the OMOP CDM version 4.0 adds value in conducting analyses due to successful mapping of the drugs and procedures. The addition of visit logic gives ordinality to drugs and procedures that wasn’t present prior to the transformation. Comparing conditions in Premier against a claims database can provide an understanding about Premier’s potential use in pharmacoepidemiology studies that are traditionally conducted via claims databases. Conclusion and Next Steps: The conversion of the Premier database into the OMOP CDM 4.0 was completed successfully. The next steps include refinement of vocabularies and mappings and continual maintenance of the transformed CDM.
Fitness Effects of Spontaneous Mutations in Picoeukaryotic Marine Green Algae

Estimates of the fitness effects of spontaneous mutations are important for understanding the adaptive potential of species. Here, we present the results of mutation accumulation experiments over 265–512 sequential generations in four species of marine unicellular green algae, Ostreococcus tauri RCC4221, Ostreococcus mediterraneus RCC2590, Micromonas pusilla RCC299, and Bathycoccus prasinos RCC1105. Cell division rates, taken as a proxy for fitness, systematically decline over the course of the experiment in O. tauri, but not in the three other species where the MA experiments were carried out over a smaller number of generations. However, evidence of mutation accumulation in 24 MA lines arises when they are exposed to stressful conditions, such as changes in osmolarity or exposure to herbicides. The selection coefficients, estimated from the number of cell divisions/day, varies significantly between the different environmental conditions tested in MA lines, providing evidence for advantageous and deleterious effects of spontaneous mutations. This suggests a common environmental dependence of the fitness effects of mutations and allows the minimum mutation/genome/generation rates to be inferred at 0.0037 in these species.
An Agent-based Peer-to-Peer Grid Computing Architecture

We propose a multi-agent based peer-to-peer grid computing architecture in this paper to solves the issues that the conventional grid architecture is limited in modeling computer systems with highly dynamic and autonomous computing resources, and its super-local resource management and scheduling strategy limits the utilization of the computing resources. Besides, the new architecture provides reasonable compatibility and interoperability with the conventional grid systems and clients.
Experimental temperature compensation on drop-on-demand Inkjet printing

The paper demonstrates the interest in using temperature compensation to stabilize drop-on-demand inkjet printing process. Experiments describing the influence of inkjet printing parameters on the droplet velocity and ejection stability are discussed. Experimental results have permitted to develop a relation between the printing parameters and the kinetic property of drops where a variation of temperature is compensated by an adjustment of pulse amplitude. This method allows to obtain stable drops velocity for a variation of 15°C, while without compensation the velocity increases by 5 m/s. Thus, drop ejection is stabilized and the print quality is optimized.
Non-operative management of splenic trauma

The risk of overwhelming postsplenectomy infection (OPSI) prompted the evolution toward preservation of the injured spleen. Nonoperative management (NOM) of blunt injury to the spleen in adults has become the standard of care in hemodynamically stable patients. This modality of treatment began in the 1970’s in paediatric patients. It is highly successful with overall failures rates from 2% to 31% (average 10.8%) - with the majority of failures occurring in the first 24 hours. Current, NOM of splenic trauma includes splenic artery embolization. However, the criteria for NOM are controversial. In this study we present the current criteria, the evolution and failure rates of this type of management viewed through the general knowledge and, particularly, our experience.
Simulation and experiment of recycle micromixer with high reflux

To overcome the low mixing efficiency near the vicinity of the wall of the micromixer, a passive micromixer using the recycle flow, with the advantages of simple structure, high reflux rate and high mixing efficiency, has been designed and investigated. In this work, the influence of different structural parameters and fluid properties on the mixing performance was studied by using commercial software ANSYS CFX. The mixing effect of micromixer was also studied by the experiments. A full comparison between the experimental results and simulation results was carried out. The numerical simulation results show that as the jet intensity increases and the viscosity of fluid becomes lower, the reflux rate and mixing efficiency of the micromixer are improved continuously; when Reynolds number (Re) is >15, the maximum reflux rate of the micromixer and the mixing efficiency exceed 35 and 95%. In addition, it was also observed that the simulation results are consistent with the experiments which revealed that the numerical simulation method applied and the results obtained in this work are reliable.
Shape Extraction Framework for Similarity Search in Image Databases

The task of similarity search in image databases has been studied for decades, while there have been many feature extraction tech- niques proposed. Among the mass of low-level techniques dealing with color, texture, layout, etc., an extraction of shapes provides better se- mantic description of the content in raster image. However, even such specific task as shape extraction is very complex, so the mere knowledge of particular raster transformation and shape-extraction techniques does not give us an answer what methods should be preferred and how to combine them, in order to achieve the desired eect in similarity search. In this paper we propose a framework consisting of low-level intercon- nectable components, which allows the user to easily configure the flow of transformations leading to shape extraction. Based on experiments, we also propose typical scenarios of transformation flow, with respect to the best shape-based description of the image content.
Improvement for Consensus Performance of Multi-Agent Systems Based on Weighted Average Prediction

The weighted average prediction (WAP) is introduced into the existing consensus protocol to simultaneously improve the robustness to communication delay and the convergence speed of achieving the consensus. It is proved that for a supercritical-delay multi-agent system, introducing the WAP can improve not only the robustness against communication delay but also the convergence speed, provided that the length of the WAP is chosen properly. The implementation of the WAP-based consensus protocol is investigated and simulations are provided to demonstrate the effectiveness of the theoretical results.
Nonlinear modelling and seismic behaviour of precast concrete structures with steel shear walls

A new structural system consisting of precast concrete frames and steel shear walls (SSW's) is introduced and studied numerically in this paper. Two different models, first using ''exact'' FEM and second using approximate equivalent strip model (ESM), are utilized for analysis of such a system with nonlinear static (pushover) procedure. In the FEM model use is made of shell elements while the ESM benefits from simple links that replace the wall panels in the model and are oriented such that they work in tension. Because of good agreement observed between the results of the models in smaller structures, for taller buildings only the ESM approach is followed where computationally applying the FEM approach is impractical. The lateral behaviour of the systems under consideration is investigated with regard to parameters such as number of stories and beam-column connection type. As a result, the ductility, overstrength and response modification factors are calculated for this new structural system as quantities required for their practical design.
ELECTROCHEMICAL FABRICATION OF THIN FILM PHOTOVOLTAIC DEVICES (CIGS & CIGSS)

20 Chapter One . 22 Introduction . 22 1.1 Solar cells as renewable energy sources . 23 1.1.1 Solar cells as energy source . 23 1.1.2 Photovoltaic panel configuration . 24 1.1.3 Solar cell operation (Efficiency and fill factor) . 25 1.2. 2 Thin film solar cells . 30 1.3. 1 CIGS . 30 1.3. 2 CIGS device structure . 31 1.3. 3 Availability . 34 1.3. 4 CIGS Defect States . 35 1.4 Production Methods . 35 1.5. 1 CIGS electrodeposition literature Review . 36 1.6 CIGS device fabrication . 44
Broadband dipole on a u-shaped cross-sectional ground plane antenna

This paper presents the broadband dipole on a u-shaped cross-sectional ground plane antenna. Its element contributes from copper on FR4 material. Poles are the rectangular patch that is chamfered at the both corner near feeding point. This antenna provides an average gain of 8.0 dBi at the HPBW of 90deg. The front-to-back ratio is greater than 20 dB on the ground plane of 160 times 140 mm2 and height of 30 mm across the frequency range of 1.6 - 2.6 GHz (VSWR<1.5:1). The antenna is fed at the central between poles by a 50 Omega coaxial cable. This antenna is suitable for fabrication as a low-cost base station antenna with a linear polarization of DCS, PCS, UMTS, and ISM bands.
Calculation of the Contact Angle of Polymer Melts on Tool Surfaces from Viscosity Parameters

It is of great importance for polymer processing whether and how viscosity influences the wettability of tool surfaces. We demonstrate the existence of a distinct relationship between the contact angle of molten polymers and zero shear viscosity in this paper. The contact angle of molten polypropylene and polymethylmethacrylate on polished steel was studied in a high temperature chamber using the sessile drop method. A high pressure capillary rheometer with a slit die was employed to determine the shear viscosity curves in a low shear rate range. A linear relation between the contact angle and zero shear viscosity was obtained. Furthermore, the contact angle and the zero shear viscosity values of the different polymers were combined to one function. It is revealed that, for the wetting of tool surfaces by molten polymers, a lower viscosity is advantageous. Furthermore, a model based on the temperature shift concept is proposed which allows the calculation of the contact angle of molten polymers on steel for different temperatures directly from shear viscosity data.
A high performance privacy-oriented location system

Many mobile applications can be greatly enhanced when provided with the locations of people and devices. Ultrasonic location systems have been shown to supply location information with centimeter accuracy at high update rates. Such high-performance systems, however, have relied upon a centralized or coordinated architecture, preventing the user from being in control of how their location information is handled and thus giving rise to privacy concerns. In this paper we present a privacy-oriented location system allowing users with mobile ultrasonic receivers to ascertain their position autonomously. We formulate a method of operation for the system, detail its implementation in a small office, and characterize the performance of the system. The utilization of broadband ultrasound makes it possible for the privacy-oriented location system to have competitive accuracy and high update rates, while allowing the user to be in direct control of their location information.
Molecular Systems Biology Peer Review Process File a Multi-scale Approach Reveals That Nf B Enforces Enforces a B-cell Decision to Divide Transaction Report

(Note: With the exception of the correction of typographical or spelling errors that could be a source of ambiguity, letters and reports are not edited. The original formatting of letters and referee reports may not be reflected in this compilation.) Thank you again for submitting your work to Molecular Systems Biology. We have now heard back from the three referees who agreed to evaluate your manuscript. As you will see from the reports below, the referees find the topic of your study and your approach of potential interest. They raise, however, several issues that should be convincingly addressed in a revision of the present study. Without repeating all the points noted by the reviewers, some of the major issues refer to the following:-the way model parameters were estimated/chosen should be clarified and the impact of these choices should be analyzed. -model fits and predictions should be analyzed and tested more rigorously with appropriate statistics. Literature points NF B as a regulator for coordinating cell growth, death and division in B cells. Whether the B cell fate decision of division versus death is a stochastic event or determined during the growth phase was unclear. Shokhirev et al. combined experimental and computational approaches, and demonstrated predetermined B cell fate during the growth phase. Furthermore, the multi-scale mathematical model allowed simulation of cellular phenotypes in response to various perturbations such as reduced exogeneous stimulation, gene knockout, increase protein abundance
The Prognostic Impact of p53 Expression on Sporadic Colorectal Cancer Is Dependent on p21 Status

The prognostic value of p53 and p21 expression in colorectal cancer is still under debate. We hypothesize that the prognostic impact of p53 expression is dependent on p21 status. The expression of p53 and p21 was immunohistochemically investigated in a prospective cohort of 116 patients with UICC stage II and III sporadic colorectal cancer. The results were correlated with overall and recurrence-free survival. The mean observation period was 51.8 ± 2.5 months. Expression of p53 was observed in 72 tumors (63%). Overall survival was significantly better in patients with p53-positive carcinomas than in those without p53 expression (p = 0.048). No differences were found in recurrence-free survival (p = 0.161). The p53+/p21− combination was seen in 68% (n = 49), the p53+/p21+ combination in 32% (n = 23). Patients with p53+/p21− carcinomas had significantly better overall and recurrence-free survival than those with p53+/p21+ (p < 0.0001 resp. p = 0.003). Our data suggest that the prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status.
Psychometric properties, factorial structure, and measurement invariance of the English and French versions of the Medical Outcomes Study social support scale.

BACKGROUND The Medical Outcomes Study (MOS) social support scale is a 19-item survey that measures four dimensions of functional support. The current study reports on the psychometric properties, factorial structure, and measurement invariance of the scale for a sample of English- and French-speaking Canadians aged 55 or older. DATA AND METHODS The internal consistency and composite reliability for a congeneric measurement model of the dimensions of functional social support were examined. A confirmatory factor analysis and test of invariance across language (English = 2,642; French = 489) were also performed. RESULTS Across both English- and French-speaking respondents, results indicated good internal consistency (Cronbach's alpha ranged from .90 to .97) and composite reliability (ranging from .93 to .97) for all dimensions of functional social support. The confirmatory factor analysis revealed acceptable fit indices for the 4-factor structure similar to the original one. The scale appears to function uniformly across both language groups. INTERPRETATION The MOS social support scale appears to be a psychometrically sound instrument for use in research on social support with samples of English- and French-speaking older adults.
Effect of Graphene Oxide on Non-Isothermal Melt Crystallization Kinetics of Poly(Trimethylene Terephthalate)

Poly (trimethylene terephthalate) (PTT)/graphene oxide (GO) nanocomposites were prepared by melt mixing. The effect of GO on non-isothermal melt crystallization kinetics of PTT with different amounts of GO were investigated by differential scanning calorimetry (DSC). The Avrami, Ozawa and Mo were used to analyze the non-isothermal crystallization process. The results of Avrami analysis showed that adding GO into PTT matrix changed the crystallization nucleation of PTT. Ozawa analysis could not be used for the non-isothermal crystallization of PTT/GO nanocomposites. According to the results of Mo analysis, a higher cooling rate would be needed in order to obtain a higher degree of crystallinity at unit crystallization time.
An Anatomy of Pairs Trading: The Role of Idiosyncratic News, Common Information and Liquidity

"Pairs trading" involves taking a bet that the price paths of two stocks that have historically moved together will converge again after any divergence. Consistent with the view that profits to pairs trading comes through market making, i.e., short term liquidity provision and price discovery; we find that pairs trading profits are higher when the initial divergence is due to (a) news that temporarily reduces the liquidity of one of the stocks in the pair, or (b) news that affects both stocks in the pair, and there are a priori reasons to believe that one stock reacts faster to such news. Profits are lower when the initial divergence in prices is associated with value relevant news specific to a stock in the pair. Pairs involving smaller, less liquid and more volatile stocks tend to converge faster after initial divergence. When one of the stocks in the pair is more likely to have sluggish response to common information as evidenced by less common sell side coverage and institutional holdings, the risk of a margin call due to further divergence is lower. Closing out positions that do not converge within 10 days leads to higher risk adjusted returns ignoring transactions costs when compared to holding positions for 6 months.
Development and characterization of microsatellite loci for Lindera glauca (Lauraceae)1

Premise of the study: Microsatellite primers were developed to investigate population genetic structure in Lindera glauca (Lauraceae). Methods and Results: Twenty-five microsatellite primers were developed and optimized for L. glauca using Illumina's Solexa sequencing technology. These novel primers were found to be polymorphic in nine wild L. glauca populations with 81 total alleles confirmed and genotyped via capillary gel electrophoresis. The total number of alleles, observed heterozygosity, and expected heterozygosity for each population ranged from one to four, from 0.00 to 0.90, and from 0.00 to 0.79, respectively. In addition, the 25 primers were tested in 10 additional individuals of the related species L. communis, and all but four markers showed good amplification results. Conclusions: This set of microsatellite primers is the first specifically developed for L. glauca and will facilitate studies of genetic diversity and evolution among populations of this species.
As-exact-as-possible repair of unprintable STL files

Purpose The class of models that can be represented by STL files is larger than the class of models that can be printed using additive manufacturing technologies. Stated differently, there exist well-formed STL files that cannot be printed. This paper aims to formalize such a gap and describe a fully automatic procedure to turn any such file into a printable model. Design/methodology/approach Based on well-established concepts from combinatorial topology, this paper provide an unambiguous description of all the mathematical entities involved in the modeling-printing pipeline. Specifically, this paper formally defines the conditions that an STL file must satisfy to be printable, and, based on these, an as-exact-as-possible repairing algorithm is designed. Findings It has been found that, to cope with all the possible triangle configurations, the algorithm must distinguish between triangles that bind solid parts and triangles that constitute zero-thickness sheets. Only the former set can be fixed without distortion. Research limitations/implications Owing to the specific approach used that tracks the so-called “outer hull,” models with inner cavities cannot be treated. Practical implications Thanks to this new method, the shift from a 3D model to a printed prototype is faster, easier and more reliable. Social implications The availability of this easily accessible model preparation tool has the potential to foster a wider diffusion of home-made 3D printing in non-professional communities. Originality/value Previous methods that are guaranteed to fix all the possible configurations provide only approximate solutions with an unnecessary distortion. Conversely, this procedure is as exact as possible, meaning that no visible distortion is introduced unless it is strictly imposed by limitations of the printing device. Thanks to such unprecedented flexibility and accuracy, this algorithm is expected to significantly simplify the modeling-printing process, in particular within the continuously emerging non-professional “maker” communities.
Peripheral Administration of a Humanized Anti-PrP Antibody Blocks Alzheimer's Disease Aβ Synaptotoxicity

Alzheimer's disease (AD) is associated with pathological assembly states of amyloid-β protein (Aβ). Aβ-related synaptotoxicity can be blocked by anti-prion protein (PrP) antibodies, potentially allowing therapeutic targeting of this aspect of AD neuropathogenesis. Here, we show that intravascular administration of a high-affinity humanized anti-PrP antibody to rats can prevent the plasticity-disrupting effects induced by exposure to soluble AD brain extract. These results provide an in vivo proof of principle for such a therapeutic strategy.