Miracle-dz/UniFAR-FTUs huggingface dataset:
Handling the differential evolution of software artefacts: A framework for consistency management

Modern software systems are subject to frequent changes. Different artefacts of a system, such as requirements specifications, design documents and source code, often evolve at different times and become inconsistent with one another. This differential evolution poses problems to effective software maintenance and erodes trust in artefacts as accurate representation of the system. In this paper, we propose a holistic framework for managing the consistent co-evolution of software artefacts, incorporating: traceability creation and maintenance, change detection, impact analysis, consistency checking and change propagation.
What nouns and adjectives in online game reviews can tell us about player experience?

This paper presents a study attempting to investigate player experience by examining nouns and adjectives used in online game reviews. Built on our previous lexical analysis of adjectives in online game reviews, we argue that nouns together with adjectives will likely provide richer information than adjectives alone. We adopted a revised lexical approach and analyzed nouns and adjectives from 821,122 structured reviews provided by different stakeholders in the game community (e.g., players, developers, and producer etc.) 97 factors were identified and ranked from 5,130 unique terms. Results were presented and discussed.
GPLSIUA: Combining Temporal Information and Topic Modeling for Cross-Document Event Ordering

Building unified timelines from a collection of written news articles requires cross-document event coreference resolution and temporal relation extraction. In this paper we present an approach event coreference resolution according to: a) similar temporal information, and b) similar semantic arguments. Temporal information is detected using an automatic temporal information system (TIPSem), while semantic information is represented by means of LDA Topic Modeling. The evaluation of our approach shows that it obtains the highest Micro-average F-score results in the SemEval2015 Task 4: TimeLine: Cross-Document Event Ordering (25.36\% for TrackB, 23.15\% for SubtrackB), with an improvement of up to 6\% in comparison to the other systems. However, our experiment also showed some draw-backs in the Topic Modeling approach that degrades performance of the system.
Bayesian Biclustering for Patient Stratification

The move from Empirical Medicine towards Personalized Medicine has attracted attention to Stratified Medicine (SM). Some methods are provided in the literature for patient stratification, which is the central task of SM, however, there are still significant open issues. First, it is still unclear if integrating different datatypes will help in detecting disease subtypes more accurately, and, if not, which datatype(s) are most useful for this task. Second, it is not clear how we can compare different methods of patient stratification. Third, as most of the proposed stratification methods are deterministic, there is a need for investigating the potential benefits of applying probabilistic methods. To address these issues, we introduce a novel integrative Bayesian biclustering method, called B2PS, for patient stratification and propose methods for evaluating the results. Our experimental results demonstrate the superiority of B2PS over a popular state-of-the-art method and the benefits of Bayesian approaches. Our results agree with the intuition that transcriptomic data forms a better basis for patient stratification than genomic data.
Elderly lung cancer patients: what treatment strategies?

‘Within a group of elderly patients of the same chronological age, some are fit and others are frail. Thus, in order to further individualize treatment choice in elderly patients, it is important to practice a comprehensive geriatric assessment. ’ Cesare Gridelli ‘SG Moscati’ Hospital, Division of Medical Oncology, Città Ospedaliera, Contrada Amoretta, 83100 Avellino, Italy Tel. : +39 082 520 3573 Fax: +39 082 520 3556 cgridelli@libero.it Expert Rev. Anticancer Ther. 7(10), 1331–1334 (2007)
For Durkheim: Essays in Historical and Cultural Sociology

Contents: Introduction: why For Durkheim? Part 1 (Re)Discovering Durkheim: Emile Durkheim's matrix On discovering Durkheim Emile Durkheim and social change Durkheim and Husserl: a comparison of the spirit of positivism and the spirit of phenomenology Durkheim, Mathiez and the French revolution: the political context of a sociological classic Situating Durkheim's sociology of work Durkheim, solidarity and September 11. Part 2 Durkheim and Cultural Change: Contextualizing the emergence of modern sociology: the Durkheimian school in search of bygone society Avant-garde art and avant-garde sociology: 'primitivism' and Durkheim ca. 1905a "1913 From Durkheim to Managua: revolutions as religious revivals Sexual anomie, social structure and societal change No laughing matter: applying Durkheim to Danish cartoons. Part 3 Durkheim and Weber: A problem for the sociology of knowledge: the mutual unawareness of Emile Durkheim and Max Weber Neither Marx nor Durkheim a | perhaps Weber Durkheim and Weber: first cousins? Collective effervescence, social change and charisma: Durkheim, Weber and 1989 On the shoulders of Weber and Durkheim: East Asia and emergent modernity Appendix Index.
Scene Representation and Object Grasping Using Active Vision

Object grasping and manipulation pose major challenges for perception and control and require rich interaction between these two fields. In this paper, we concentrate on the plethora of perceptual problems that have to be solved before a robot can be moved in a controlled way to pick up an object. A vision system is presented that integrates a number of different computational processes, e.g. attention, segmentation, recognition or reconstruction to incrementally build up a representation of the scene suitable for grasping and manipulation of objects. Our vision system is equipped with an active robotic head and a robot arm. This embodiment enables the robot to perform a number of different actions like saccading, fixating, and grasping. By applying these actions, the robot can incrementally build a scene representation and use it for interaction. We demonstrate our system in a scenario for picking up known objects from a table top. We also show the system’s extendibility towards grasping of unknown and familiar objects.
A Clinical Parameters-Based Model Predicts Anastomotic Leakage After a Laparoscopic Total Mesorectal Excision

AbstractAnastomotic leakage after colorectal surgery is a major and life-threatening complication that occurs more frequently than expected. Intraoperative judgment in predicting potential leakage has shown extremely low sensitivity and specificity. The lack of a model for predicting anastomotic leakage might explain this insufficient judgment. We aimed to propose a clinical parameters-based model to predict anastomotic leakage after laparoscopic total mesorectal excision (TME). This study was a retrospective analysis of a prospectively designed colorectal cancer dataset. In total, 1968 patients with a laparoscopic TME were enrolled from November 1, 2010, to March 20, 2014. The independent risk factors for anastomotic leakage were identified, from which the parameters-based model for leakage was developed.Anastomotic leakage was noted in 63 patients (3.2%). Male sex, a low level of anastomosis, intraoperative blood loss, diabetes, the duration time of the surgery, and low temperature were significantly associated by the bivariate analysis and the Cochran–Mantel–Haenszel test with an increased risk. From these factors, the logistic regression model identified the following 4 independent predictors: male sex (risk ratio [RR] = 1.85, 95% confidence interval [CI]: 1.13–4.87), diabetes (RR = 2.08, 95% CI: 1.19–5.8), a lower anastomosis level (RR = 3.41, 95% CI: 1.17–6.71), and a high volume of blood loss (RR = 1.03, 95% CI: 1.01–1.05). The locally weighted scatterplot smoothing regression showed an anastomosis within 5 cm from the anus and intraoperative blood loss of >100 mL as the cutoff values for a significantly increased risk of leakage. Based on these independent factors, a parameters-based model was established by the regression coefficients. The high and low-risk groups were classified according to scores of 3–5 and 0–2, with leakage rates of 8.57% and 1.66%, respectively (P < 0.001). This parameters-based model could predict the risk of anastomotic leakage following laparoscopic rectal cancer. After further validation, this model might facilitate the intraoperative recognition of high-risk patients to perform defunctional stomas.
Wisdom: The study of wise persons: integrating a personality perspective

The primacy of cognitive explanations of wisdom in recent research has failed to incorporate personality prerequisites. Fundamental links between wisdom and adult personality development, elucidated by several personality theorists, are summarized in the first part of this chapter. We identify two key indicators of personality-based wisdom: advanced self-development and selftranscendence. Wisdom depends on an unusually integrated personality structure that enables people to transcend personalistic perspectives and embrace collective and universal concerns. We assume, however, that these personality attributes presuppose complementary cognitive development and that wisdom is rare precisely because it entails both exceptional personality and cognitive growth. In the second part of this chapter, we propose an empirical approach to the study of wisdom that capitalizes on the integration of personality and cognition by intensively studying adults who are considered wise. In this approach, subject selection is guided by nominations of wise people and measure selection is guided by both cognitive and personality theories. We elaborate how this approach can be applied to the study of wisdom by discussing useful ingredients from several other research traditions. Finally, we provide an empirical foundation for the study of wise people by summarizing current research. Personality conceptualization of wisdom Hypotheses about a personality dimension of wisdom can be drawn from three personality theorists who have dealt explicitly with wisdom: Erikson, Jung, and Kohut. Although these theorists have different orientations to personality (i.e., Erikson's psychosocial, Jung's analytical, and Kohut's object relations), each discussed self-development and self-transcendence as key attributes of the wise personality.
Concise and Expressive Mappings with +Spicy

We introduce the +Spicy mapping system. The system is based on a number of novel algorithms that contribute to increase the quality and expressiveness of mappings. +Spicy integrates the computation of core solutions in the mapping generation process in a highly efficient way, based on a natural rewriting of the given mappings. This allows for an efficient implementation of core computations using common runtime languages like SQL or XQuery and guarantees very good performances, orders of magnitude better than those of previous algorithms. The rewriting algorithm can be applied both to mappings generated by the system, or to pre-defined mappings provided as part of the input. To do this, the system was enriched with a set of expressive primitives, so that +Spicy is the first mapping system that brings together a sophisticate and expressive mapping generation algorithm with an efficient strategy to compute core solutions.
Sequential electron microscopical study of experimental mouse skin carcinogenesis

Electron microscopical study of experimentally induced skin tumours was undertaken. The investigation was designed to determine the sequence of morphological changes between first painting with a carcinogen (methylcholanthrene) and the development of invasive neoplasms. It was found that changes occurred in both the epidermis and the dermis but that the most profound disturbances affected the region of the dermoepidermal junction.
Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells

Single channel and whole cell recordings were used to study ion permeation through Ca channels in isolated ventricular heart cells of guinea pigs. We evaluated the permeability to various divalent and monovalent cations in two ways, by measuring either unitary current amplitude or reversal potential (Erev). According to whole cell measurements of Erev, the relative permeability sequence is Ca2+ greater than Sr2+ greater than Ba2+ for divalent ions; Mg2+ is not measurably permeant. Monovalent ions follow the sequence Li+ greater than Na+ greater than K+ greater than Cs+, and are much less permeant than the divalents. These whole cell measurements were supported by single channel recordings, which showed clear outward currents through single Ca channels at strong depolarizations, similar values of Erev, and similar inflections in the current-voltage relation near Erev. Information from Erev measurements stands in contrast to estimates of open channel flux or single channel conductance, which give the sequence Na+ (85 pS) greater than Li+ (45 pS) greater than Ba2+ (20 pS) greater than Ca2+ (9 pS) near 0 mV with 110-150 mM charge carrier. Thus, ions with a higher permeability, judged by Erev, have lower ion transfer rates. In another comparison, whole cell Na currents through Ca channels are halved by less than 2 microM [Ca]o, but greater than 10 mM [Ca]o is required to produce half-maximal unitary Ca current. All of these observations seem consistent with a recent hypothesis for the mechanism of Ca channel permeation, which proposes that: ions pass through the pore in single file, interacting with multiple binding sites along the way; selectivity is largely determined by ion affinity to the binding sites rather than by exclusion by a selectivity filter; occupancy by only one Ca ion is sufficient to block the pore's high conductance for monovalent ions like Na+; rapid permeation by Ca ions depends upon double occupancy, which only becomes significant at millimolar [Ca]o, because of electrostatic repulsion or some other interaction between ions; and once double occupancy occurs, the ion-ion interaction helps promote a quick exit of Ca ions from the pore into the cell.
Electrophysiological Measures of Time Processing in Infant and Adult Brains: Weber's Law Holds

Behavioral studies have demonstrated that time perception in adults, children, and nonhuman animals is subject to Weber's Law. More specifically, as with discriminations of other features, it has been found that it is the ratio between two durations rather than their absolute difference that controls the ability of an animal to discriminate them. Here, we show that scalp-recorded event-related electrical brain potentials (ERPs) in both adults and 10-month-old human infants, in response to changes in interstimulus interval (ISI), appear to obey the scalar property found in time perception in adults, children, and nonhuman animals. Using a timing-interval oddball paradigm, we tested adults and infants in conditions where the ratio between the standard and deviant interval in a train of homogeneous auditory stimuli varied such that there was a 1:4 (only for the infants), 1:3, 1:2, and 2:3 ratio between the standard and deviant intervals. We found that the amplitude of the deviant-triggered mismatch negativity ERP component (deviant-ISI ERP minus standard-ISI ERP) varied as a function of the ratio of the standard to deviant interval. Moreover, when absolute values were varied and ratio was held constant, the mismatch negativity did not vary.
Stat1-Dependent, p53-Independent Expression of p21waf1 Modulates Oxysterol-Induced Apoptosis

ABSTRACT 7-Ketocholesterol (7kchol) is prominent in atherosclerotic lesions where apoptosis occurs. Using mouse fibroblasts lacking p53, p21waf1, or Stat1, we found that optimal 7kchol-induced apoptosis requires p21waf1 and Stat1 but not p53. Findings were analogous in a human cell system. Apoptosis was restored in Stat1-null human cells when wild-type Stat1 was restored. Phosphorylation of Stat1 on Ser727 but not Tyr701 was essential for optimum apoptosis. A neutralizing antibody against beta interferon (IFN-β) blunted Ser727 phosphorylation and apoptosis after 7kchol treatment; cells deficient in an IFN-β receptor subunit exhibited blunted apoptosis. IFN-β alone did not induce apoptosis; thus, 7kchol-induced release of IFN-β was necessary but not sufficient for optimal apoptosis. In Stat1-null cells, expression of p21waf1 was much less than in wild-type cells; introducing transient expression of p21waf1 restored apoptosis. Stat1 and p21waf1 were essential for downstream apoptotic events, including cytochrome c release from mitochondria and activation of caspases 9 and 3. Our data reveal key elements of the cellular pathway through which an important oxysterol induces apoptosis. Identification of the essential signaling events that may pertain in vivo could suggest targets for therapeutic intervention.
Engineering a Ca++-Sensitive (Bio)Sensor from the Pore-Module of a Potassium Channel

Signals recorded at the cell membrane are meaningful indicators of the physiological vs. pathological state of a cell and will become useful diagnostic elements in nanomedicine. In this project we present a coherent strategy for the design and fabrication of a bio-nano-sensor that monitors changes in intracellular cell calcium concentration and allows an easy read out by converting the calcium signal into an electrical current in the range of microampere that can be easily measured by conventional cell electrophysiology apparatus.
Guanine sulphinate is a major stable product of photochemical oxidation of DNA 6-thioguanine by UVA irradiation

The DNA of patients taking the immunosuppressant and anticancer drugs azathioprine or 6-mercaptopurine contains 6-thioguanine (6-TG). The skin of these patients is selectively sensitive to ultraviolet A radiation (UVA) and they suffer an extremely high incidence of sunlight-induced skin cancer with long-term treatment. DNA 6-TG interacts with UVA to generate reactive oxygen species, which oxidize 6-TG to guanine sulphonate (GSO3). We suggested that GSO3 is formed via the reactive electrophilic intermediates, guanine sulphenate (GSO) and guanine sulphinate (GSO2). Here, GSO2 is identified as a significant and stable UVA photoproduct of free 6-TG, its 2′-deoxyribonucleoside, and DNA 6-TG. Mild chemical oxidation converts 6-TG into GSO2, which can be further oxidized to GSO3—a stable product that resists further reaction. In contrast, GSO2 is converted back to 6-TG under mild conditions. This suggests that cellular antioxidant defences might counteract the UVA-mediated photooxidation of DNA 6-TG at this intermediate step and ameliorate its biological effects. In agreement with this possibility, the antioxidant ascorbate protected DNA 6-TG against UVA oxidation and prevented the formation of GSO3.
Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field

Individuals with 22q11 deletion syndrome (22q11DS; DiGeorge/velo-cardio-facial syndrome) have multiple congenital malformations, including cardiovascular defects. Most individuals with this syndrome possess 1.5-3.0 Mb hemizygous 22q11.2 deletions. The T-box transcription factor TBX1, lies within the nested 1.5 Mb interval and is a strong candidate for its etiology. Inactivation of Tbx1 in the mouse results in neonatal lethality owing to the presence of a single cardiac outflow tract. One important goal is to understand the molecular pathogenesis of cardiovascular defects in this syndrome. However, the molecular pathways of Tbx1 are still largely unexplored. Here, we show that Tbx1 is co-expressed with the bicoid-like homeodomain transcription factor Pitx2 in secondary heart field cells in the pharyngeal mesenchyme. In situ hybridization studies in Tbx1-/- mouse embryos revealed downregulation of Pitx2 in these cells. To test for a possible genetic interaction, we intercrossed Tbx1+/- and Pitx2+/- mice. Tbx1+/-; Pitx2+/- mice died perinatally with cardiac defects, including double outlet right ventricle, and atrial and ventricular septal defects, all occurring with variable penetrance. An enhancer located between exons 4 and 5 in which a putative T-half site was identified near an Nkx2.5-binding site regulates asymmetric expression of Pitx2. We show using in vitro studies that Tbx1 binds to this site and activates the Pitx2 enhancer with the synergistic action of Nkx2.5. The results presented in this study unravel a novel Tbx1-Pitx2 pathway linking Tbx1 to asymmetric cardiac morphogenesis.
Using observation of teaching to improve quality

This paper begins by reviewing some of the different models of third-party observation of university teaching that can be found in the literature. Having analysed these, it argues that if ‘peer’ is taken to indicate equality of status only one is genuinely a model of peer-observation. It proposes an alternative categorisation of third-party observations of teaching dependant on who controls the information generated by the process. A preferred six-dimensional model based on control by the person being observed of the data-flow, and other procedural aspects, is presented and explored. Evaluative comments, by university teachers who have undertaken the process, are presented to illustrate the benefits of adopting this model.
Optimal Configuration of 802.11e EDCA for Real-Time and Data Traffic

The enhanced distributed channel access (EDCA) mechanism of the IEEE 802.11e standard provides quality-of-service (QoS) support through service differentiation by using different medium-access-control (MAC) parameters for different stations. The configuration of these parameters, however, is still an open research challenge, as the standard provides only a set of fixed recommended values that do not take into account the current wireless local area network (WLAN) conditions and, therefore, lead to suboptimal performance. In this paper, we propose a novel algorithm for EDCA that, given the throughput and delay requirements of the stations that are present in the WLAN, computes the optimal configuration of the EDCA parameters. We first present a throughput and delay analysis that provides the mathematical foundation upon which our algorithm is based. This analysis is validated through simulations of different traffic sources (both data and real time) and EDCA configurations. We then propose a mechanism to derive the optimal configuration of the EDCA parameters, given a set of performance criteria for throughput and delay. We assess the effectiveness of the configuration provided by our algorithm by comparing it against 1) the recommended values by the standard, 2) the results from an exhaustive search over the parameter space, and 3) previous configuration proposals, which are both standard and nonstandard compliant. Results show that our configuration outperforms all other approaches.
Extended web services for remote collaborative manipulation in distributed augmented reality

In this paper we present an extended formalism of web services for developing a Remote Collaborative Manipulation system in Augmented Reality Environment. This system is an Internet-based virtual 3D environment that provides users a shared space and a collaborative platform for publishing, simulating and analyzing multidimensional data. In this paper, we have constructed our collaborative system using web services technology. The architecture and the system's working mechanisms based on the extended web services were elaborated. To demonstrate Remote Collaborative Manipulation system, we have examined a case study of automotive design.