Miracle-dz/UniFAR-FTUs huggingface dataset:
Research of news text with word frequency statistics and user information

This paper focuses on the news collection of a single topic, analyzes the large number of keywords and phrases in the news, uses the traditional TF-IDF algorithm based on the word frequency, adds the weight to the tags, extracts the keywords which have certain use value in the news, and uses the tag selection formula to tag the news. In addition, collect user reviews on the Internet news portal to create user comments information tags library for the news tag group to make the news tags more fit user needs. In this paper, the value of the tag is measured by the recall rate and the F1 score, and the tag based on the news content is analyzed according to the intermediate variable in the model operation. It also summarizes the general content of the topic by analyzing the tags distribution of the news collection.
Tribological behaviours of textured surfaces under conformal and non-conformal starved lubricated contact conditions

Wear tests were carried out using a pin-on-disc tester. The sliding friction experiments were made using textured and untextured discs of 50 HRC hardness, under starved lubricated conditions in unidirectional sliding. Two batches of tests were done. The special construction was made to obtain conformal contact in the first type of tests. In the second test type in non-conformal initial point contact condition, a steel disc was put in contact with a ball from bearing steel of 3.175 mm radius. Two kinds of textured discs were tested; the oil pockets were positioned in spiral and radial arrays the number of oil pockets within friction track also varied. It was found that in conformal contact conditions the presence of dimples resulted in considerable decrease of the friction force compared to untextured samples. Surface texturing caused transition from point to conformal contact during test, which resulted in decrease of friction force but increase of wear of balls. The tribological behaviour of assembly with spiral dimples layout was better than that with radial array of oil pockets.
Auditory structural connectivity in preterm and healthy term infants during the first postnatal year

Assessing language development in the first postnatal year is difficult, as receptive and expressive skills are rudimentary. Although outward manifestations of change are limited, the auditory language system is thought to undergo critical development at this age, as the foundations are laid for the rapid onset of spoken language in the second and third years. We recruited 11 infants, 7 healthy controls (gestational age = 40.69 ± 0.56; range from 40 to 41.43) and preterm babies (gestational age = 28.04 ± 0.95; range from 27.43 to 29.43) who underwent a Magnetic Resonance Imaging study during the first postnatal year (age at scan = 194.18 ± 97.98). We assessed white matter tracts using diffusion-weighted magnetic resonance imaging with probabilistic tractography. Fractional anisotropy was found to be largely mature even at one month, although there was a little further increase during the first postnatal year in both the acoustic radiation and the direct brainstem-Heschl's pathway.
Development of Helisoma trivolvis pond snails as biological samplers for biomonitoring of current‐use pesticides

Nontarget aquatic organisms residing in wetlands are commonly exposed to current‐use pesticides through spray drift and runoff. However, it is frequently challenging to measure exposure because of rapid dissipation of pesticides from water and reduced bioavailability. The authors' hypothesis is that freshwater snails can serve as bioindicators of pesticide exposure based on their capacity to passively accumulate tissue residues. Helisoma trivolvis snails were evaluated as biomonitors of pesticide exposure using a fungicide formulation that contains pyraclostrobin and metconazole and is frequently applied to crops surrounding depressional wetlands. Exposure–response studies indicate that H. trivolvis are tolerant of pyraclostrobin and metconazole at concentrations >10 times those lethal to many aquatic species, with a median lethal concentration based on pyraclostrobin of 441 μg/L (95% confidence interval of 359–555 μg/L). Bioconcentration factors ranged from 137 mL/g to 211 mL/g and from 39 mL/g to 59 mL/g for pyraclostrobin and metconazole, respectively. Elimination studies suggested one‐compartmental elimination and snail tissue half‐lives (t50) of approximately 15 h and 5 h for pyraclostrobin and metconazole, respectively. Modeling derived toxicokinetic parameters in the context of an environmentally relevant pulsed exposure suggests that residues can be measured in snails long after water concentrations fall below detection limits. With high fungicide tolerance, rapid accumulation, and slow elimination, H. trivolvis may be viable for biomonitoring of pyraclostrobin and should be investigated for other pesticides. Environ Toxicol Chem 2016;35:2320–2329. © 2016 SETAC
JSweep: A Patch-centric Data-driven Approach for Parallel Sweeps on Large-scale Meshes

In mesh-based numerical simulations, sweep is an important computation pattern. During sweep on meshes, computations on cells are strictly ordered by data dependencies in given directions. Due to this order constraint, parallelizing sweep is challenging, especially for unstructured and deforming meshes. Meanwhile, recent high-fidelity multi-physics simulations of particle transport, including nuclear reactor and inertial confinement fusion, require sweeps on large scale meshes with billions of cells and hundreds of directions. In this paper, we present JSweep, a parallel data-driven framework integrated in the JAxMIN infrastructures. The essential of JSweep is a general patch-centric data-driven abstraction, coupled with a high performance runtime system leveraging hybrid parallelism of MPI+threads and achieving dynamic communication on contemporary multi-core clusters. Built on JSweep, we implement a representative data-driven algorithm, Sn transport, featuring optimizations of vertex clustering, multi-level priority strategy and patch-angle parallelism. Experimental evaluation with two real-world applications on structured and unstructured meshes respectively, demonstrates that JSweep can scale to tens of thousands of processor cores with reasonable parallel efficiency.
Enabling SIMT Execution Model on Homogeneous Multi-Core System

Single-instruction multiple-thread (SIMT) machine emerges as a primary computing device in high-perfor-mance computing, since the SIMT execution paradigm can exploit data-level parallelism effectively. This article explores the SIMT execution potential on homogeneous multi-core processors, which generally run in multiple-instruction multiple-data (MIMD) mode when utilizing the multi-core resources. We address three architecture issues in enabling SIMT execution model on multi-core processor, including multithreading execution model, kernel thread context placement, and thread divergence. For the SIMT execution model, we propose a fine-grained multithreading mechanism on an ARM-based multi-core system. Each of the processor cores stores the kernel thread contexts in its L1 data cache for per-cycle thread-switching requirement. For divergence-intensive kernels, an Inner Conditional Statement First (ICS-First) mechanism helps early re-convergence to occur and significantly improves the performance. The experiment results show that effectiveness in data-parallel processing reduces on average 36% dynamic instructions, and boosts the SIMT executions to achieve on average 1.52× and up to 5× speedups over the MIMD counterpart for OpenCL benchmarks for single issue in-order processor cores. By using the explicit vectorization optimization on the kernels, the SIMT model gains further benefits from the SIMD extension and achieves 1.71× speedup over the MIMD approach. The SIMT model using in-order superscalar processor cores outperforms the MIMD model that uses superscalar out-of-order processor cores by 40%. The results show that, to exploit data-level parallelism, enabling the SIMT model on homogeneous multi-core processors is important.
Rank selection of CP-decomposed convolutional layers with variational Bayesian matrix factorization

Convolutional Neural Networks (CNNs) is one of successful method in many areas such as image classification tasks. However, the amount of memory and computational cost needed for CNNs inference obstructs them to run efficiently in mobile devices because of memory and computational ability limitation. One of the method to compress CNNs is compressing the layers iteratively, i.e. by layer-by-layer compression and fine-tuning, with CP-decomposition in convolutional layers. To compress with CP-decomposition, rank selection is important. In the previous approach rank selection that is based on sensitivity of each layer, the average rank of the network was still arbitrarily selected. Additionally, the rank of all layers were decided before whole process of iterative compression, while the rank of a layer can be changed after fine-tuning. Therefore, this paper proposes selecting rank of each layer using Variational Bayesian Matrix Factorization (VBMF) which is more systematic than arbitrary approach. Furthermore, to consider the change of each layer's rank after fine-tuning of previous iteration, the method is applied just before compressing the target layer, i.e. after fine-tuning of the previous iteration. The results show better accuracy while also having more compression rate in AlexNet's convolutional layers compression.
Finding the Sweet Spot(s)

Creating actionable plans has been shown to be helpful in promoting physical activity. However, little rèsearch has been done on how best to support the creation and execution of plans. In this paper, we interviewed 16 participants to study the role that context plays in the formulation and execution of plans for physical activity. Our findings highlight nuanced ways that contextual factors interact with each other and with individual differences to impact planning. We propose the notion of sweet spots to encapsulate how particular contextual factors converge to create optimal states for performing physical activities. The concept of sweet spots helped us to better understand the creation and execution of plans made by our participants. We present design guidelines to show how sweet spots can help support physical activity planning and guide the design of context-based tools for planning support.
Biomimetic implants for pelvic floor repair

Polypropylene implants are used for the reconstructive surgery of urogynaecological disorders like pelvic organ prolapse, but severe complications associated with their use have been reported. There is evidence that surface properties and a difference in mechanical stiffness between the implant and the host tissue contribute to these adverse events. Electrospinning is an innovative engineering alternative that provides a biomimetic microstructure for implants, resulting in a different mechano‐biological performance.
Evolution of optic nerve photography for glaucoma screening: a review

Visual evaluation of the optic nerve has been one of the earliest and most widely used methods to evaluate patients for glaucoma. Photography has proven very useful for documentation of the nerve's appearance at a given time, allowing more detailed scrutiny then, and later comparison for change. Photography serves as the basis for real‐time or non‐simultaneous review in telemedicine and screening events allowing fundus and optic nerve evaluation by experts elsewhere. Expert evaluation of disc photographs has shown diagnostic performance similar to other methods of optic nerve evaluation for glaucoma. Newer technology has made optic nerve photography simpler, cheaper and more portable creating opportunities for broader utilization in screening in underserved populations by non‐physicians. Recent investigations suggest that non‐physicians or software algorithms for disc photograph evaluation have promise to allow more screening to be done with fewer experts.
Novel, nano-sized, liposome-encapsulated polyamidoamine dendrimer derivatives facilitate tumour targeting by overcoming the polyethylene glycol dilemma and integrin saturation obstacle

Abstract Drug delivery systems (DDSs) commonly employ arginine–glycine–aspartic acid (RGD) peptides with polyethylene glycol (PEG)-dependent enhanced permeability and retention (EPR) effect to optimise tumour-targeting. However, the PEG dilemma and integrin saturation obstacle are major challenges. To address these issues, we constructed a novel, nano-sized DDS by encapsulating doxorubicin (DOX)-loaded folic acid derivatives of polyamidoamine dendrimer (PAMAM G5.0) in cyclic RGD-tyrosine-lysine pentapeptide (c[RGDyK])-modified liposomes (RGD-SL[FND/DOX]), prepared using thin-film hydration, film-dispersion and hydration-sonication. The liposomes were PEGylated, sterically stabilised and pH-sensitive. In vitro, RGD-SL[FND/DOX] showed pH-sensitive holistic FND/DOX release, and pH-dependent uptake and cytotoxicity in human cancer KB cells. At pH 7.4, RGD-SL[FND/DOX] demonstrated greater cellular uptake and cytotoxicity than relevant control formulations (except FND/DOX) did, although this advantage disappeared at pH 6.5. In vivo, RGD-SL[FND/DOX] inhibited S180 sarcoma xenografted tumour growth in Kunming mice more effectively than FND/DOX did. These findings demonstrate the feasibility of constructing double-stage tumour-targeting nano-sized DDSs such as RGD-SL[FND/DOX]. c[RGDyK] and the EPR effect, facilitated by the particle size (about 110 nm) and PEGylation, helped to target the DDS to the tumour tissue, while the subsequent pH-dependent release of FND/DOX and folic acid-mediated endocytosis specifically targeted the tumour cells, thereby overcoming the PEG dilemma and integrin saturation obstacle.
Kudingcha and Fuzhuan Brick Tea Prevent Obesity and Modulate Gut Microbiota in High‐Fat Diet Fed Mice

SCOPE Kudingcha (KDC) from Ilex kudingcha and Fuzhuan brick tea (FBT) are popular beverages in China, and their preventive and therapeutic roles in metabolic disorders have been reported. However, the relationship between the gut microbiota modulatory effects of KDC and FBT and prevention of obesity is still not clearly understood. METHODS AND RESULTS KDC and FBT are tested individually for their capacities to prevent obesity and modulate the gut microbiota in high-fat diet (HFD) fed C57BL/6J mice. The results show that both KDC and FBT supplementation could modulate oxidative injury, inflammation, lipid metabolism, and reduce HFD induced obesity significantly. Both KDC and FBT could enhance the diversity of gut microbiota. KDC could reduce the relative abundance of Erysipelotrichaceae, while FBT could reduce the ratio of Firmicutes to Bacteroidetes and enhance the relative abundance of Bifidobacteriaceae. CONCLUSION These findings suggest that KDC and FBT could attenuate features of the metabolic syndrome in HFD-fed mice, which might be due to the modulation of gut microbiota by KDC and FBT.
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

In contrast to mouse epidermal cells, human skin keratinocytes are rather resistant to transformation in vitro. Immortalization has been achieved by SV40 but has resulted in cell lines with altered differentiation. We have established a spontaneously transformed human epithelial cell line from adult skin, which maintains full epidermal differentiation capacity. This HaCaT cell line is obviously immortal (greater than 140 passages), has a transformed phenotype in vitro (clonogenic on plastic and in agar) but remains nontumorigenic. Despite the altered and unlimited growth potential, HaCaT cells, similar to normal keratinocytes, reform an orderly structured and differentiated epidermal tissue when transplanted onto nude mice. Differentiation- specific keratins (Nos. 1 and 10) and other markers (involucrin and filaggrin) are expressed and regularly located. Thus, HaCaT is the first permanent epithelial cell line from adult human skin that exhibits normal differentiation and provides a promising tool for studying regulation of keratinization in human cells. On karyotyping this line is aneuploid (initially hypodiploid) with unique stable marker chromosomes indicating monoclonal origin. The identity of the HaCaT line with the tissue of origin was proven by DNA fingerprinting using hypervariable minisatellite probes. This is the first demonstration that the DNA fingerprint pattern is unaffected by long- term cultivation, transformation, and multiple chromosomal alterations, thereby offering a unique possibility for unequivocal identification of human cell lines. The characteristics of the HaCaT cell line clearly document that spontaneous transformation of human adult keratinocytes can occur in vitro and is associated with sequential chromosomal alterations, though not obligatorily linked to major defects in differentiation.
Automatic assessment of functional suppression of the central nervous system due to propofol anesthetic infusion. From EEG phenomena to a quantitative index

The rationale for automatically monitoring anesthetic drug effects on the central nervous system (CNS) is to improve possibilities to gain objective information on a patient's state and to adjust the medication individually. Although monitors have shown their usefulness in practice, there are still a number of unclear issues, especially with respect to the scientific foundations and validity of CNS monitoring techniques, and in monitoring the light hypnotic levels. Current monitors are, for example, often based on heuristics and ad hoc solutions. However, a quantitative index for anesthetic drug effect should have a sound relationship with observations and with the selected control variable. The research objectives are: (1) to explore propofol anesthetic related neurophysiological phenomena that can be applied in the automatic assessment of CNS suppression; (2) to develop a valid control variable for this purpose; (3) by means of digital signal processing and mathematical modeling, to design and to evaluate the performance of an index that correlates with the control variable. This dissertation introduces potentially useful neurophysiological phenomena, such as changes in phase synchronization between different EEG channels due to anesthesia, and painful stimulus evoked responses during the burst suppression. Furthermore, it refines the progression of the timefrequency patterns during the induction of anesthesia and shows their relation to the instant of unresponsiveness. The presented spontaneous and evoked EEG phenomena provide complementary information about the CNS functional suppression. Most significantly, the dissertation proposes a continuous and observation based control variable (r scale) and the means to predict its values by using EEG data. The definition of the scale provides a basis for anticipating the instant of the loss of consciousness. Additionally, the phase synchronization index as an indicator of drug effect is introduced. The approximate entropy descriptor performance is evaluated and optimised with a non-stationary signal recorded during the induction of anesthesia. The results open up opportunities to improve the preciseness, scientific validity and the interpretation of information on the anesthetic effects on CNS, and therefore, to increase the reliability of the anesthesia monitoring. Further work is needed to extend and verify the results in deep anesthesia.
Seasonality of odonate‐mediated methylmercury flux from permanent and semipermanent ponds and potential risk to red‐winged blackbirds (Agelaius phoeniceus)

Methylmercury (MeHg) is an aquatic contaminant that can be transferred to terrestrial predators by emergent aquatic insects such as odonates (damselflies and dragonflies). We assessed the effects of month and pond permanence on odonate‐mediated MeHg flux (calculated as emergent odonate biomass × MeHg concentration) in 10 experimental ponds and the potential risk to nestling red‐winged blackbirds (Agelaius phoeniceus) posed by consuming MeHg‐contaminated odonates. Emergent odonates were collected weekly from permanent ponds with bluegill (Lepomis macrochirus; n = 5) and semipermanent ponds without fish (n = 5) over an 8‐mo period (January–August 2015). The MeHg flux from damselflies, aeshnid dragonflies, and libellulid dragonflies began in March and peaked in April, May, and June, respectively, and then declined throughout the rest of the summer. Odonate‐mediated MeHg flux from semipermanent ponds without fish was greater than that from permanent ponds with fish. Nesting of red‐winged blackbirds overlapped with peak odonate emergence and odonate‐mediated MeHg flux. Because their diet can be dominated by damselflies and dragonflies, we tested the hypothesis that MeHg‐contaminated odonates may pose a health risk to nestling red‐winged blackbirds. Concentrations of MeHg in odonates exceeded wildlife values (the minimum odonate MeHg concentrations causing physiologically significant doses in consumers) for nestlings, suggesting that MeHg‐contaminated odonates can pose a health risk to nestling red‐winged blackbirds. Environ Toxicol Chem 2017;36:2833–2837. © 2017 SETAC
Both inorganic and organic selenium supplements can decrease brain monoamine oxidase B enzyme activity in adult rats

It has been observed that the levels of brain monoamine oxidase B (MAO-B) increase during ageing. MAO catalyses the oxidative deamination of neurotransmitters, in which the by-product H2O2 is subsequently generated. Se exists naturally in inorganic and organic forms and is considered to play a key role in antioxidation functioning. The objective of the present study was to investigate two chemical forms of Se compounds for their inhibition effect on rat brain MAO-B. The total antioxidant capacity and lipid peroxidation of rats were also examined. The rats (age 7 weeks) were divided into four groups: the control group, tocopherol group (T group, positive control), selenite group (SE group, representing the inorganic Se group) and seleno-yeast group (SY group, representing the organic Se group). The rats were fed for 11 weeks with normal diets and 12 weeks with test diets. The serum total antioxidant capacity of the SE and SY groups was significantly higher than that in the control and T groups. In rat brains and livers, the lipid peroxidation levels were significantly decreased in the T, SE and SY groups. MAO-B activity showed a significant decrease in the T, SE and SY groups in rat brains but no significant change could be noted in the rat livers. In conclusion, the present study indicates that inorganic or organic Se supplementation can decrease the brain MAO-B enzyme activity in adult rats and can be accomplished by the effect of the Se antioxidation capability.
Public Git Archive: A Big Code Dataset for All

The number of open source software projects has been growing exponentially. The major online software repository host, GitHub, has accumulated tens of millions of publicly available Git version-controlled repositories. Although the research potential enabled by the available open source code is clearly substantial, no significant large-scale open source code datasets exist. In this paper, we present the Public Git Archive – dataset of 182,014 top-bookmarked Git repositories from GitHub. We describe the novel data retrieval pipeline to reproduce it. We also elaborate on the strategy for performing dataset updates and legal issues. The Public Git Archive occupies 3.0 TB on disk and is an order of magnitude larger than the current source code datasets. The dataset is made available through HTTP and provides the source code of the projects, the related metadata, and development history. The data retrieval pipeline employs an optimized worker queue model and an optimized archive format to efficiently store forked Git repositories, reducing the amount of data to download and persist. Public Git Archive aims to open a myriad of new opportunities for "Big Code" research.