Miracle-dz/UniFAR-FTUs huggingface dataset:
Séville et l'Atlantique (1504-1650)

CHAUNU (Huguette e Pierre) . — Seville et l'Atlantique (1504-1650) . Tomos I, II e III. 1955. in 8. °, XV+322+603+572 pp. 12 cartas. (Segundo Paragrafo do Artigo) Uma tal apresentacao, pelo mestre da historiografia francesa dos nossos dias, tira-nos as palavras que poderiam servir-nos para dizer os nossos sentimentos diante do pedido que fez Pierre Chaunu para assinalar seu livro aos amigos da Revista de Historia e do Brasil.
Spatial Distribution Measurement of Dynamic Voltage Drop Caused by Pulse and Periodic Injection of Spot Noise

This paper presents measured results of dynamic voltage drop caused by pulse and periodic injection of spot noise. The test structure being fabricated by a 45 nm low-power process has 1024 delay probes to measure spatial distributions in response to the spot-noise generation. The test structure is the advanced version of our predecessor being fabricated by a 65-nm node, and can trace changes in the spatial distributions with time after the noise injection. The measured results are compared with SPICE simulations, in which package/socket LCR as well as power-line RC within the die is modeled. It is found that the simple model agrees well with the measured results.
Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior

Chronic inflammation and subsequent tissutal alterations may play a key role in prostate carcinogenesis. In this way, molecular alterations of the suppressor of cytokine signaling 3 (SOCS3), one of the most important inhibitory molecule of inflammatory signal transduction circuitries, could contribute to explain the pleiotropic role of interleukin‐6 (IL‐6) in this type of cancer.
Enzyme-Linked Immunosorbent Assays Using the Recombinant Dense Granule Antigens GRA6 and GRA1 of Toxoplasma gondii for Detection of Immunoglobulin G Antibodies

ABSTRACT The potential of the dense granule antigens GRA1 and GRA6 ofToxoplasma gondii to be used as diagnosis reagents in a recombinant form was evaluated. Both proteins were expressed inEscherichia coli as glutathione-S-transferase (GST) fusions. The GST-GRA1 fusion comprises the entire GRA1 sequence devoid of its N-terminal signal peptide. Separate expression of the two N- and C-terminal hydrophilic regions of GRA6 showed that only the N-terminal hydrophilic part of the protein was recognized by a pool of positive human sera in an immunoblot. One hundred T. gondii-positive and 98 negative human sera were tested in two separate immunoglobulin G (IgG)-direct enzyme-linked immunosorbent assays (ELISAs) using either GST-GRA1 or GST-GRA6-Nt recombinant protein. Whereas the sensitivity of the GST-GRA1 IgG ELISA was low (68%), the GST-GRA6-Nt IgG ELISA reached a sensitivity of 96%. The reactivity to GRA6-Nt was shown to be high even with human sera of low IgG titers. In addition, comparison of the optical density values for each serum revealed that GRA1 may complement GRA6-Nt to reach an overall sensitivity of 98%. Therefore, the GST-GRA6-Nt ELISA could be used together with another antigen like GRA1 for the development of a recombinant antigen-based test for serodiagnosis of toxoplasmosis.
Haptic Perception with Self-Organizing ANNs and an Anthropomorphic Robot Hand

We have implemented and compared four biologically motivated self-organizing haptic systems based on proprioception. All systems employ a 12-d.o. f. anthropomorphic robot hand, the LUCS Haptic Hand 3. The four systems differ in the kind of self-organizing neural network used for clustering. For the mapping of the explored objects, one system uses a Self-Organizing Map (SOM), one uses a Growing Cell Structure (GCS), one uses a Growing Cell Structure with Deletion of Neurons (GCS-DN), and one uses a Growing Grid (GG). The systems were trained and tested with 10 different objects of different sizes from two different shape categories. The generalization abilities of the systems were tested with 6 new objects. The systems showed good performance with the objects from the training set as well as in the generalization experiments. Thus the systems could discriminate individual objects, and they clustered the activities into small cylinders, large cylinders, small blocks, and large blocks. Moreover, the self-organizing ANNs were also organized according to size. The GCS-DN system also evolved disconnected networks representing the different clusters in the input space (small cylinders, large cylinders, small blocks, large blocks), and the generalization samples activated neurons in a proper subnetwork in all but one case.
Observations of Intergranular Stress Corrosion Cracking in a Grain-Mapped Polycrystal

Nondestructive three-dimensional mapping of grain shape, crystallographic orientation, and grain boundary geometry by diffraction contrast tomography (DCT) provides opportunities for the study of the interaction between intergranular stress corrosion cracking and microstructure. A stress corrosion crack was grown through a volume of sensitized austenitic stainless steel mapped with DCT and observed in situ by synchrotron tomography. Several sensitization-resistant crack-bridging boundaries were identified, and although they have special geometric properties, they are not the twin variant boundaries usually maximized during grain boundary engineering.
Health economic review of recombinant activated factor VII for treatment of bleeding episodes in hemophilia patients with inhibitors

Severe hemophilia with inhibitors is a rare disease with substantial clinical, humanistic and economic consequences. This review provides an overview of the role of recombinant activated factor VII (rFVIIa) versus plasma-derived bypassing agents for hemophilia with inhibitors and summarizes the 13 formal economic analyses (6 burden of illness and 7 comparative studies) that have been published in this indication. The findings suggest that the economic impact of rFVIIa has occurred primarily during hospitalization to manage major bleeding episodes and to allow for elective orthopedic surgeries that would not have been attempted prior to rFVIIa. Comparative analyses for on-demand treatment suggest that the total cost of treating a bleeding episode with rFVIIa may be lower than with plasma-based agents due to faster bleeding resolution, higher initial efficacy rates and avoidance of second and third lines of treatment.
Noninvasive Methods for Arterial Stiffness Measurement Systemic Determination of Arterial Stiffness

This review analyses methods and devices used worldwide to evaluate the arterial stiffness. Three main methodologies are based upon analysis of pulse transit time, of wave contour of the arterial pulse, and of direct measurement of arterial geometry and pressure, corresponding to regional, systemic and local determination of stiffness. They are used in clinical laboratory and/or in clinical departments. Particular attention is given to the reproducibility data in literature for each device. This article summarizes the discussion of the dedicated Task Force during the first Conference of Consensus on Arterial Stiffness held in June 2000 (Paris, France). Am J Hypertens 2002;15:743–753 © 2002 American Journal of Hypertension, Ltd.
Elastography of breast lesions: initial clinical results.

PURPOSE To determine the appearance of various breast lesions on elastograms and to explore the potential of elastography in the diagnosis of breast lesions. MATERIALS AND METHODS A total of 46 breast lesions were examined with elastography. Patients underwent biopsy or aspiration of all lesions, revealing 15 fibroadenomas, 12 carcinomas, six fibrocystic nodules, and 13 other lesions. The elastogram was generated from radio-frequency data collected with use of a 5-MHz linear-array transducer. The elastogram and corresponding sonogram were evaluated by a single observer for lesion visualization, relative brightness, and margin definition and regularity. The sizes of the lesions at each imaging examination and at biopsy were recorded and compared. RESULTS Softer tissues such as fat appear as bright areas on elastograms. Firm tissues, including parenchyma, cancers, and other masses, appear darker. The cancers were statistically significantly darker than fibroadenomas (P < .005) and substantially larger on the elastogram than on the sonogram. Seventy-three percent of fibroadenomas and 56% of solid benign lesions could be distinguished from cancers by using lesion brightness and size difference. Some cancers that appeared as areas of shadowing on sonograms appeared as discrete masses on elastograms. CONCLUSION Elastography has the potential to be useful in the evaluation of areas of shadowing on the sonogram. It also may be helpful in the distinction of benign from malignant masses.
Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro

The human parvovirus adeno-associated virus (AAV) is unique in its ability to target viral integration to a specific site on chromosome 19 (ch-19). Recombinant AAV (rAAV) vectors retain the ability to integrate but have apparently lost this ability to target. In this report, we characterize the terminal-repeat-mediated integration for wild-type (wt), rAAV, and in vitro systems to gain a better understanding of these differences. Cell lines latent for either wt or rAAV were characterized by a variety of techniques, including PCR, Southern hybridization, and fluorescence in situ hybridization analysis. More than 40 AAV-rAAV integration junctions were cloned, sequenced, and then subjected to comparison and analysis. In both immortalized and normal diploid human cells, wt AAV targeted integration to ch-19. Integrated provirus structures consisted of head-to-tail tandem arrays with the majority of the junction sequences involving the AAV inverted terminal repeats (ITRs). No complete viral ITRs were directly observed. In some examples, the AAV p5 promoter sequence was found to be fused at the virus-cell junction. Data from dot blot analysis of PCR products were consistent with the occurrence of inversions of genomic and/or viral DNA sequences at the wt integration site. Unlike wt provirus junctions, rAAV provirus junctions mapped to a subset of non-ch-19 sequences. Southern analysis supported the integration of proviruses from two independent cell lines at the same locus on ch-2. In addition, provirus terminal repeat sequences existed in both the flip and flop orientations, with microhomology evident at the junctions. In all cases with the exception of the ITRs, the vector integrated intact. rAAV junction sequence data were consistent with the occurrence of genomic rearrangement by deletion and/or rearrangement-translocation at the integration locus. Finally, junctions formed in an in vitro system between several AAV substrates and the ch-19 target site were isolated and characterized. Linear AAV substrates typically utilized the end of the virus DNA substrate as the point of integration, whereas products derived from AAV terminal repeat hairpin structures in the presence or absence of Rep protein resembled AAV-ch-19 junctions generated in vivo. These results describing wt AAV, rAAV, and in vitro integration junctions suggest that the viral integration event itself is mediated by terminal repeat hairpin structures via nonviral cellular recombination pathways, with specificity for ch-19 in vivo requiring additional viral components. These studies should have an important impact on the use of rAAV vectors in human gene therapy.
Human Heart Conjugate Cooling Process : Unsteady Thermo-Fluid-Stress Analysis

The main objective of this work was to demonstrate computationally that realistic human hearts can be cooled much faster by performing conjugate heat transfer consisting of pumping a cold liquid through the cardiac chambers and major veins while keeping the heart submerged in cold gelatine filling a cooling container. The human heart geometry used for simulations was obtained from three-dimensional, high resolution MRI scans. Two fluid flow domains for the right (pulmonic) and left (systemic) heart circulations, and two solid domains for the heart tissue and gelatine solution were defined for multi-domain numerical simulation. Detailed unsteady temperature fields within the heart tissue was were calculated during the conjugate cooling process. A linear stress analysis was performed to assess the stresses applied on the heart due to the coolant fluid shear and normal forces and to examine the thermal stress caused by temperature variation inside the heart. It was demonstrated that an unoptimized conjugate cooling effort with coolant temperature at +4°C is capable of reducing the average heart temperature from +37°C to +8°C in 25 minutes in for cases in which the coolant was pumped only through major heart veins and cavities. when heart vasculature is not included in the perfusion cooling scheme.
Mitigation of Non-Eliminated Harmonics of Three-Level Multipulse Three-Phase Active Front End Converters with Low Switching Frequency

A Three-Level 12 pulse Three-Phase Active Front End ensures reduced low order harmonics influence and therefore minimizes volume and amount of network side filters. This paper presents the experimental study concerning the regenerative unity-power factor operation of a 3LAFE converter, highlighting the possible reduction of non-eliminated harmonics by the introduction of slight variations of modulation index and DC-Link voltage regarding a selective harmonic distortion factor (SHD). This work opens new possibilities for avoiding or reducing harmonic filters, especially by operating within weak networks and stringent conditions to be studied in further projects
Extended Self-Critical Pipeline for Transforming Videos to Text (TRECVID-VTT Task 2021) - Team: MMCUniAugsburg

The Multimedia and Computer Vision Lab of the University of Augsburg participated in the VTT task only. We use the VATEX and TRECVID-VTT datasets for training our VTT models. We base our model on the Transformer approach for both of our submitted runs. For our second model, we adapt the X-Linear Attention Networks for Image Captioning which does not yield the desired bump in scores. For both models, we train on the complete VATEX dataset and 90% of the TRECVID-VTT dataset for pretraining while using the remaining 10% for validation. We finetune both models with self-critical sequence training, which boosts the validation performance significantly. Overall, we find that training a Video-to-Text system on traditional Image Captioning pipelines delivers very poor performance. When switching to a Transformer-based architecture our results greatly improve and the generated captions match better with the corresponding video.
Evaluation of methods to decrease the discharge temperature of R32 scroll compressor

Recently, R32 has been considered as an important alternative in application of small to middle capacity air conditioner by many countries due to its advantages such as low global warming potential (GWP), favorable thermal properties, less refrigerant charge and low cost. However, the much increased discharge temperature of R32 compressor, as compared with the R22, becomes the main barrier affecting the wide and quick adoption. Refrigerant injection has proven to be effective in decreasing discharge temperature. In this work, three kinds of refrigerant injection technology used to decrease the discharge temperature of R32 scroll compressor are discussed, namely, two-phase suction, liquid injection and two-phase/gas injection. The detailed scroll compressor model proposed in previous work is modified and validated by experimental data of R32 scroll compressor. The potentials in decreasing discharge temperature of the three methods are investigated. The detailed performance comparisons are presented. The results indicate that the two-phase/gas injection achieves the best performance with the enhancement of cooling capacity by 14.2% and increase in COP by 8.1%.
The Problem of Synforms in Serbian Efl Learners Revisited

Abstract This paper will explore the issue of similar lexical forms (Laufer 1991) as a potential problem in vocabulary acquisition of Serbian EFL learners. Building on previous research (Kocić 2008), we collected data from two groups of undergraduate students at the Faculty of Philology and Arts in Kragujevac (lower- and upper-intermediate), and attempted to identify the factors that contribute to synform confusions.
A new two-dimensional analytical model for short-channel Tri-material gate-stack SOI MOSFET’s

Based on the exact solution of the two-dimensional Poisson equation, a new analytical behavior model consisting of the two-dimensional potential and threshold voltage for the short-channel tri-material gate-stack SOI MOSFETpsilas is developed. The model is verified by its good agreement with the numerical simulation of the device simulator MEDICI. The model not only offers physical insight into the device physics but also provides guidance for the basic design of the device.
Treatment of Heparin‐Induced Thrombocytopenia: Is There a Role for Bivalirudin?

The recognition and management of heparin‐induced thrombocytopenia (HIT) and heparin‐induced thrombocytopenia with thrombosis syndrome (HITTS) has been evolving over the past several years. Although HIT is a relatively uncommon adverse event in patients receiving heparin therapy, it bears a significant risk of thrombotic events. If patients are left untreated, 50% can develop thrombosis. Several direct thrombin inhibitors have been studied as alternative anticoagulants in patients with HIT. Lepirudin and argatroban are both approved by the United States Food and Drug Administration (FDA) for the management of HIT. Lepirudin requires dosage adjustments in patients with renal insufficiency and has potential for antibody formation. Argatroban requires dosage adjustments in patients with hepatic insufficiency. Argatroban increases the international normalized ratio when coadministered with warfarin, leading to dosage difficulties when transitioning to warfarin therapy. Bivalirudin is the most recent direct thrombin inhibitor to be introduced to the market, but it is not currently FDA approved for HIT. Controversy stills exists over which direct thrombin inhibitor to use, especially in acutely ill patients and in those requiring invasive or surgical procedures. Bivalirudin has a relatively short half‐life and a predictable response, which makes it attractive as an anticoagulant in patients requiring invasive or surgical procedures, those who are acutely ill, or patients with both renal and hepatic insufficiency. It offers promise as an additional direct thrombin inhibitor for use in patients with HIT, but additional studies need to be performed to further define its use.
GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling

Significance In this study, we identify nerve-released glial cell line-derived neurotrophic factor (GDNF) family receptor (GFR)α1 as a key factor that enhances perineural invasion (PNI) through GDNF-Ret proto-oncogene (RET) signaling. We demonstrate that GFRα1 is released from nerves in a soluble form and cooperates with secreted GDNF to activate cancer cell surface RET, activating downstream signaling, cancer cell migration, and PNI. These findings advance our understanding of the molecular mechanisms of PNI and define the specific cancer cell requirements necessary for PNI to occur. This work promotes the concept that a ligand and receptor both released by the microenvironment may cooperate together to facilitate cancer invasion. These findings highlight the key participatory role that the nerve microenvironment plays in enabling cancer perineural invasion. The ability of cancer cells to invade along nerves is associated with aggressive disease and diminished patient survival rates. Perineural invasion (PNI) may be mediated by nerve secretion of glial cell line-derived neurotrophic factor (GDNF) attracting cancer cell migration through activation of cell surface Ret proto-oncogene (RET) receptors. GDNF family receptor (GFR)α1 acts as coreceptor with RET, with both required for response to GDNF. We demonstrate that GFRα1 released by nerves enhances PNI, even in the absence of cancer cell GFRα1 expression. Cancer cell migration toward GDNF, RET phosphorylation, and MAPK pathway activity are increased with exposure to soluble GFRα1 in a dose-dependent fashion. Dorsal root ganglia (DRG) release soluble GFRα1, which potentiates RET activation and cancer cell migration. In vitro DRG coculture assays of PNI show diminished PNI with DRG from GFRα1+/− mice compared with GFRα1+/+ mice. An in vivo murine model of PNI demonstrates that cancer cells lacking GFRα1 maintain an ability to invade nerves and impair nerve function, whereas those lacking RET lose this ability. A tissue microarray of human pancreatic ductal adenocarcinomas demonstrates wide variance of cancer cell GFRα1 expression, suggesting an alternate source of GFRα1 in PNI. These findings collectively demonstrate that GFRα1 released by nerves enhances PNI through GDNF-RET signaling and that GFRα1 expression by cancer cells enhances but is not required for PNI. These results advance a mechanistic understanding of PNI and implicate the nerve itself as a key facilitator of this adverse cancer cell behavior.
[Mapping genes related to early onset major depressive disorder in Dagestan genetic isolates].

AIM The purpose of this study was to determine the molecular epidemiology of early onset major depressive disorder (MDD) in genetic isolates of the Caucasus Dagestan indigenous ethnic populations using molecular and statistical population-genetic approaches. METHODS Two multigenerational pedigrees from two diverse remote highland isolates with aggregation of early onset MDD were ascertained within our long-term research program titled 'Dagestan Genetic Heritage, DGH'. The first isolate included 48 cases of MDD (19 living) with 11 suicides committed, and the second included 60 MDD cases (30 living) with 12 suicides committed. The phenotypes of the affected family members were determined using a database containing diagnoses from a regional psychiatric hospital and through our own clinical examinations, which were based on a Russian translation of DIGS software based on the DSM-IV criteria . A 10 cM genomic scan (Weber/CHLC 9.0 STRs) of the 64 affected and non-affected members of the pedigrees was performed and the data was used for multipoint parametric linkage analyses. Following this scan, selected cases were analyzed by Affymetrix 6.0 SNP arrays in order to refine the contribution of copy number variations (CNVs) to the genetic basis of MDD. RESULTS We found a total of 18 genomic regions with nominal (LOD>1.3) linkage to MDD across the two isolates. Three genomic regions had genome-wide significant (LOD>3) linkages and were found at 2p13.2-p11.2, 14q31.12-q32.13 and 22q12.3. We also confirmed previous findings for MDD at 4q25, 11p15, 12q23-24, 13q31-32, 18q21-22 and 22q11-13. Six linkage regions were observed in both genetic isolates, while 12 other linkages demonstrated population-specific heterogeneity. We detected CNV rearrangements within 12 of the 18 linkage regions. Affected subjects had the highest rate of genomic instability within the linkage regions at 2p13.2-p11.2, 4q25-q28.2, 7p14.1, 8p23, 14q31.12-q32.13, 18q22.1 and 20p13. CONCLUSION The results obtained in this study suggest that mapping genes of complex diseases, including MDD, across genetically homogeneous isolates can help detect linkage signals and expedite the search for susceptibility genes when combined with methods that detect structural genomic variation in linkage regions.