Miracle-dz/UniFAR-FTUs huggingface dataset:
Cooperative spectrum sensing and analysis of the optimum users number based on the primary user transmission with relay

In the paper, we combine the detection model that primary users with the help of relay with multiple secondary users to perform cooperative spectrum sensing. We consider the influence of some parameters to make the overhead more efficient, and analyze the relay amplification gain can efficiently alleviate the performance loss caused by report channel fading. Moreover, we verify the existence of the optimal number of cooperative users, and explore the influences of the amplification gain and reporting error probability on the optimal number of users. The simulations show that the detection performance of our scheme is improved greatly compared to traditional scheme, and theoretical analysis matches well with simulation, which verifies the correctness of the theoretical analysis. Additionally, the optimal number of users is inversely proportional to the reporting error probability, and it is proportional to the relay amplification gain. In the case of the specific report channels, to achieve the maximum detection probability based on the desired probability of false alarm, the appropriate parameters should be identified, such as the relay amplification gain and the optimum number of cooperative users.
The Interpretation of Miracles according to Mutahhari and Golshani: Comparative and Critical Notes

In this essay, I scrutinize the interpretation of miracles advanced by Ayatollah Motahhari (1920-1979), the well-known Shi‘a scholar; and Mehdi Golshani (1939-), a physicist and philosopher of science. The essay begins with a presentation of their viewpoints on the nature of miracles in the light of the broader philosophical discourse on the nature of miracles. This is followed by a comparative analysis of their viewpoints with a consideration of relevant Qur’anic passages and their philosophical relevance. Finally, it concludes with a discussion of the challenges inherent to their interpretations.
Fully dynamic transitive closure: breaking through the O(n/sup 2/) barrier

We introduce a general framework for casting fully dynamic transitive closure into the problem of reevaluating polynomials over matrices. With this technique, we improve the best known bounds for fully dynamic transitive closure, in particular we devise a deterministic algorithm for general directed graphs that achieves O(n/sup 2/) amortized time for updates, while preserving unit worst-case cost for queries. In case of deletions only, our algorithm performs updates faster in O(n) amortized time. Our matrix-based approach yields an algorithm for directed acyclic graphs which breaks through the O(n/sup 2/) barrier on the single-operation complexity of fully dynamic transitive closure. We can answer queries in O(n/sup /spl epsiv//) time and perform updates in O(n/sup /spl omega/(1,/spl epsiv/,1)-/spl epsiv//+n/sup 1+/spl epsiv//) time, for any /spl epsiv//spl isin/[0,1], where /spl omega/(1,/spl epsiv/,1) is the exponent of the multiplication of an n/spl times/n/sup /spl epsiv// matrix by an n/sup /spl epsiv///spl times/n matrix. The current best bounds on /spl omega/(1,/spl epsiv/,1) imply an O(n/sup 0.575/) query time and an O(n/sup 1.575/) update time. Our subquadratic algorithm is randomized, and has one-side error.
Corpora Amylacea in Neurodegenerative Diseases: Cause or Effect?

The presence of corpora amylacea (CA) in the CNS is associated with both normal aging and neurodegenerative conditions including Alzheimer’s disease (AD) and vascular dementia (VaD). CA are spherical bodies ranging in diameter (10–50 μm) and whose origin has been documented to be derived from both neural and glial sources. CA are reported to be primarily composed of glucose polymers, but approximately 4% of the total weight of CA is consistently composed of protein. CA are typically localized in the subpial, periventricular and perivascular regions within the CNS. The presence of CA in VaD has recently been documented and of interest was the localization of CA within the hippocampus proper. Despite numerous efforts, the precise role of CA in normal aging or disease is not known. The purpose of this mini review is to highlight the potential function of CA in various neurodegenerative disorders with an emphasis on the potential role if any these structures may play in the etiology of these diseases.
Field prediction in urban environment using ray tracing

For wireless communication system in urban area, received signal level is important in determining the coverage of the system. This paper presents a model to predict the field strength level on streets inside a campus with steep terrain due to a UTMS base station at 949.2 MHz on rooftop using 3D ray tracing method. Measurements is conducted using isotropic antenna to calibrate the transmit power of antenna in the model. With the simulation model, the field strength around the campus is computed.
A Ser49Cys variant in the ataxia telangiectasia, mutated, gene that is more common in patients with breast carcinoma compared with population controls

Mothers of children who have ataxia telangiectasia have been reported to be at increased risk for development of breast carcinoma. To test whether sequence variants in the ataxia telangiectasia, mutated, gene (ATM) are associated with breast carcinoma, the authors compared the frequency of ATM cDNA sequence changes in patients with breast carcinoma with the corresponding frequency in control patients.
Profiling Insulin Like Factor 3 (INSL3) Signaling in Human Osteoblasts

Background Young men with mutations in the gene for the INSL3 receptor (Relaxin family peptide 2, RXFP2) are at risk of reduced bone mass and osteoporosis. Consistent with the human phenotype, bone analyses of Rxfp2 −/− mice showed decreased bone volume, alterations of the trabecular bone, reduced mineralizing surface, bone formation, and osteoclast surface. The aim of this study was to elucidate the INSL3/RXFP2 signaling pathways and targets in human osteoblasts. Methodology/Principal Findings Alkaline phosphatase (ALP) production, protein phosphorylation, intracellular calcium, gene expression, and mineralization studies have been performed. INSL3 induced a significant increase in ALP production, and Western blot and ELISA analyses of multiple intracellular signaling pathway molecules and their phosphorylation status revealed that the MAPK was the major pathway influenced by INSL3, whereas it does not modify intracellular calcium concentration. Quantitative Real Time PCR and Western blotting showed that INSL3 regulates the expression of different osteoblast markers. Alizarin red-S staining confirmed that INSL3-stimulated osteoblasts are fully differentiated and able to mineralize the extracellular matrix. Conclusions/Significance Together with previous findings, this study demonstrates that the INSL3/RXFP2 system is involved in bone metabolism by acting on the MAPK cascade and stimulating transcription of important genes of osteoblast maturation/differentiation and osteoclastogenesis.
Complete Alternative Splicing Events Are Bubbles in Splicing Graphs

Eukaryotic splicing structures are known to involve a high degree of alternative forms derived from a premature transcript by alternative splicing (AS). With the advent of new sequencing technologies, evidence for new splice forms becomes increasingly available-bit by bit revealing that the true splicing diversity of "AS events" often comprises more than two alternatives and therefore cannot be sufficiently described by pairwise comparisons as conducted in analyzes hitherto. Especially, I emphasize on "complete" AS events which include all hitherto known variants of a splicing variation. Challenges emerge from the richness of data (millions of transcripts) and artifacts introduced during the technical process of obtaining transcript sequences ("noise")-especially when dealing with single-read sequences known as expressed sequence tags (ESTs). Herein, I describe a novel method to efficiently predict AS events in different resolutions ("dimensions") from transcript annotations that allows for combination of fragmented EST data with full-length cDNAs and can cope with large datasets containing noise. At the doorstep of many new splice forms becoming available by novel high-throughput sequencing technologies, the presented method helps to dynamically update AS databases. Applying this method to estimate the real complexity of alternative splicing, I found in human and murine annotations thousands of novel AS events that either have been disregarded or mischaracterized in earlier works. The growth of evidence for such events suggests that the number still keeps climbing. When considering complete events, the majority of exons that are observed as "mutually exclusive" in pairwise comparisons in fact involves at least one other alternative splice form that disagrees with their mutual exclusion. Similar observations also hold for the alternative skipping of two subsequent exons. Results suggest that the systematical analysis of complete AS events on large scale provides subtle insights in the mechanisms that drive (alternative) splicing.
Link spam target detection using page farms

Currently, most popular Web search engines adopt some link-based ranking methods such as PageRank. Driven by the huge potential benefit of improving rankings of Web pages, many tricks have been attempted to boost page rankings. The most common way, which is known as link spam, is to make up some artificially designed link structures. Detecting link spam effectively is a big challenge. In this article, we develop novel and effective detection methods for link spam target pages using page farms. The essential idea is intuitive: whether a page is the beneficiary of link spam is reflected by how it collects its PageRank score. Technically, how a target page collects its PageRank score is modeled by a page farm, which consists of pages contributing a major portion of the PageRank score of the target page. We propose two spamicity measures based on page farms. They can be used as an effective measure to check whether the pages are link spam target pages. An empirical study using a newly available real dataset strongly suggests that our method is effective. It outperforms the state-of-the-art methods like SpamRank and SpamMass in both precision and recall.
Networks of practice in science education research: A global context

In this paper, we employ cultural sociology and Braj Kachru's model of World Englishes as theoretical and analytical tools for considering English as a form of capital necessary for widely disseminating research findings from local networks of practice to the greater science education research community. We present a brief analysis of recent authorship in top-tier science journals to demonstrate the salience of English language dominance as an issue in our field and we share narrative reflections from 11 international science education researchers offering perspectives from the field about the challenges faced by researchers in local and global contexts. Using an interpretive research stance, we discuss these narrative reflections to illuminate the role of personal and collective responsibility of individuals, organizations and institutions within local social networks of practice to recognize the relationship between capital, power, and equitable participation within a global science education research community. We conclude by discussing some existing structures within local networks of practice that relegate some members of the community to peripheral participatory roles in the global community and we suggest new structures to support individuals to more equitably contribute to the production of knowledge in the field of science education in ways that benefit not only individuals, but also the global science education community. © 2011 Wiley Periodicals, Inc., Inc. J Res Sci Teach 48: 592–623, 2011
Notch, IL-1 and Leptin Crosstalk Outcome (NILCO) Is Critical for Leptin-Induced Proliferation, Migration and VEGF/VEGFR-2 Expression in Breast Cancer

High levels of pro-angiogenic factors, leptin, IL-1, Notch and VEGF (ligands and receptors), are found in breast cancer, which is commonly correlated with metastasis and lower survival of patients. We have previously reported that leptin induces the growth of breast cancer and the expression of VEGF/VEGFR-2 and IL-1 system. We hypothesized that Notch, IL-1 and leptin crosstalk outcome (NILCO) plays an essential role in the regulation of leptin-mediated induction of proliferation/migration and expression of pro-angiogenic molecules in breast cancer. To test this hypothesis, leptin's effects on the expression and activation of Notch signaling pathway and VEGF/VEGFR-2/IL-1 were determined in mouse (4T1, EMT6 and MMT) breast cancer cells. Remarkably, leptin up-regulated Notch1-4/JAG1/Dll-4, Notch target genes: Hey2 and survivin, together with IL-1 and VEGF/VEGFR-2. RNA knockdown and pharmacological inhibitors of leptin signaling significantly abrogated activity of reporter gene-luciferase CSL (RBP-Jk) promoter, showing that it was linked to leptin-activated JAK2/STAT3, MAPK, PI-3K/mTOR, p38 and JNK signaling pathways. Interestingly, leptin upregulatory effects on cell proliferation/migration and pro-angiogenic factors Notch, IL-1 and VEGF/VEGFR-2 were abrogated by a γ-secretase inhibitor, DAPT, as well as siRNA against CSL. In addition, blockade of IL-1R tI inhibited leptin-induced Notch, Hey2 and survivin as well as VEGF/VEGFR-2 expression. These data suggest leptin is an inducer of Notch (expression/activation) and IL-1 signaling modulates leptin effects on Notch and VEGF/VEGFR-2. We show for the first time that a novel unveiled crosstalk between Notch, IL-1 and leptin (NILCO) occurs in breast cancer. Leptin induction of proliferation/migration and upregulation of VEGF/VEGFR-2 in breast cancer cells were related to an intact Notch signaling axis. NILCO could represent the integration of developmental, pro-inflammatory and pro-angiogenic signals critical for leptin-induced cell proliferation/migration and regulation of VEGF/VEGFR-2 in breast cancer. Targeting NILCO might help to design new pharmacological strategies aimed at controlling breast cancer growth and angiogenesis.
A highly adaptable capacity and invisibility 3D watermarking based on four-points sets

In this paper, we propose a fine tuneable capacity and invisibility novel blind watermarking method for 3D models with arbitrary topology in spatial domain. Our atermarking approach is based on a novel four-points sets construction and selection scheme to embed watermark in the vertices of the 3D models. Experimental results show that the capacity and invisibility of the watermarked models can be monotonically adjusted. To the best of our knowledge, our novel method can provide much better watermark visibility than other state-of-the-art watermarking method, while maintain large capacity and strong robustness against various typical attacks including cropping, RST transformations and local attacks. The low computational complexity of both the embedding and the extraction processes makes it suitable for copyright protection of 3D models.
Lobe Specific Ca2+-Calmodulin Nano-Domain in Neuronal Spines: A Single Molecule Level Analysis

Calmodulin (CaM) is a ubiquitous Ca2+ buffer and second messenger that affects cellular function as diverse as cardiac excitability, synaptic plasticity, and gene transcription. In CA1 pyramidal neurons, CaM regulates two opposing Ca2+-dependent processes that underlie memory formation: long-term potentiation (LTP) and long-term depression (LTD). Induction of LTP and LTD require activation of Ca2+-CaM-dependent enzymes: Ca2+/CaM-dependent kinase II (CaMKII) and calcineurin, respectively. Yet, it remains unclear as to how Ca2+ and CaM produce these two opposing effects, LTP and LTD. CaM binds 4 Ca2+ ions: two in its N-terminal lobe and two in its C-terminal lobe. Experimental studies have shown that the N- and C-terminal lobes of CaM have different binding kinetics toward Ca2+ and its downstream targets. This may suggest that each lobe of CaM differentially responds to Ca2+ signal patterns. Here, we use a novel event-driven particle-based Monte Carlo simulation and statistical point pattern analysis to explore the spatial and temporal dynamics of lobe-specific Ca2+-CaM interaction at the single molecule level. We show that the N-lobe of CaM, but not the C-lobe, exhibits a nano-scale domain of activation that is highly sensitive to the location of Ca2+ channels, and to the microscopic injection rate of Ca2+ ions. We also demonstrate that Ca2+ saturation takes place via two different pathways depending on the Ca2+ injection rate, one dominated by the N-terminal lobe, and the other one by the C-terminal lobe. Taken together, these results suggest that the two lobes of CaM function as distinct Ca2+ sensors that can differentially transduce Ca2+ influx to downstream targets. We discuss a possible role of the N-terminal lobe-specific Ca2+-CaM nano-domain in CaMKII activation required for the induction of synaptic plasticity.
Computing Discrete Minimal Surfaces and Their Conjugates

We present a new algorithm to compute stable discrete minimal surfaces bounded by a number of fixed or free boundary curves in R 3, S 3 and H 3. The algorithm makes no restr iction on the genus and can handl e singular triangulations. Additionally, we present an algorithm that, starting from a discrete harmonic map, gives a conjugate harmonic map. This can be applied to the identity map on a minimal surface to produce its conjugate minimal surface, a procedure that often yields unstable solutions to a free boundary value problem for minimal surfaces. Symmetry properties of boundary curves are respected during conjugation.
By-Person Factor Analysis in Clinical Ethical Decision Making: Q Methodology in End-of-Life Care Decisions

Objective: To determine the usefulness of Q methodology to locate and describe shared subjective influences on clinical decision making among participant physicians using hypothetical cases containing common ethical issues. Design: Qualitative study using by-person factor analysis of subjective Q sort data matrix. Setting: University medical center. Participants: Convenience sample of internal medicine attending physicians and house staff (n = 35) at one midwestern academic health sciences center. Interventions: Presented with four hypothetical cases involving urgent decision making near the end of life, participants selected one of three specific clinical actions offered for each case. Immediately afterward and while considering their decision, each respondent sorted twenty-five subjective self-referent items in terms of the influence of each statement on their decision-making process. By-person factor analysis, where participants are defined as variates, yielded information about the attitudinal background the physicians brought to their consideration of each hypothetical case. We performed a second-order factor analysis on all of the subjective viewpoints to determine if a smaller core of shared attitudes existed across some or all of the four case vignettes. Factor scores for each item and post-sort comments from interviews conducted individually with each respondent guided the interpretation of ethical perspective used by these respondents in making clinical decisions about the cases. Measurements and Main Results: Second-order factor analysis on seventeen viewpoints used by physicians in the four hypothetical urgent decision cases revealed three moderately correlated (r 2 < 40%) subjective core attitudinal guides used broadly among all the cases and among sixteen of the seventeen original factors. Across all the cases, our participants were guided in general by: (1) patient-focused beneficence, (2) a patient- and surrogate-focused perspective that includes risk avoidance, and (3) best interest of the patient guided by ethical values. Economic impact on the physician, expediency in resolution of the situation, and the expense of medical treatment were not found to be influential determinants in this study. Conclusions: Q sorting and by-person factor analysis are useful qualitative methodological tools to study the complex structure of subjective attitudes that influence physicians in making medical decisions. This study revealed the subjective viewpoints used by our physician participants as they made ethically challenging treatment decisions. The three second-order factors identified here are grounded in current bioethical values as well as the personal traits of physicians. The participants' decision methods appear to resemble casuistry more than principle-based decision making. Generalizability of results will require further studies.
Reduced Serologic Response to Newcastle Disease Virus in Broiler Chickens Exposed to a Chinese Field Strain of Subgroup J Avian Leukosis Virus

Abstract In this study, a Chinese field strain of subgroup J avian leukosis virus (ALV-J), NX0101, was studied for its immunosuppressive effects in both commercial broilers and SPF white Leghorn chickens infected at 1 day of age. Our data demonstrated that NX0101 induced much more significant body and immune organ weight loss in the infected commercial broiler chickens in an earlier age than that in the SPF white Leghorn chickens. At the same time antibody responses to vaccinations of Newcastle disease virus (NDV) and infectious bursa disease virus (IBDV) in the NX0101-infected chickens were also evaluated and compared between the commercial broiler chickens and the SPF white Leghorn chickens. Compared with the control group of chickens, the hemagglutination inhibition (HI) antibody response to NDV vaccines was significantly reduced in the NX0101-infected commercial broiler chickens from as early as 20 days after vaccination. However, no significant difference in HI antibody response was seen when HI titers reached their peaks in the NX0101-inoculated and control SPF white Leghorn chickens, except it declined significantly faster in infected birds. Neither of these two types of chickens showed significant decrease of antibody response to IBDV vaccination. Herein, we conclude that this NX0101 strain of ALV-J could selectively suppress humoral immune reactions to NDV, especially in broilers. But challenge experiments were not conducted and, therefore, it cannot be known if decreased antibody levels correlated with decreased protection against NDV in this case.