Miracle-dz/UniFAR-FTUs huggingface dataset:
Phenolic composition, antioxidant capacity of Salvia verticcilata and effect on multidrug resistant bacteria by flow-cytometry.

BACKGROUND Antioxidants are of great importance for preventing oxidative stress that may cause several degenerative diseases. Studies have indicated phytochemicals have high free-radical scavenging activity, which helps to reduce the risk of chronic diseases. The aim of the present study is the determination of antioxidant properties, polyphenolic content and multidrug resistant bacteria of Salvia verticcilata L. MATERIALS AND METHODS Methanol was used as the extraction solvent. The total phenolic content was calculated using Folin-Ciocalteau method and phenolic composition was determined by HPLC. The radical scavenging activity of plant was evaluated in vitro based on the reduction of the stable DPPH free radical. The reducing capacity was identified by using the FRAP method. The ability of Salvia verticcilata L. to increase the permeability of multidrug resistant bacterial cells was conducted by flow cytometric assay on Listeria innocua and E-coli. RESULTS The amount of total phenolics was found to be 347.5 mg GA/g extract. The IC50 value and FRAP assay are 0.61, and 0.944 respectively, Free radical scavenging effect and FRAP values are less than synthetic antioxidant compounds (BHA and BHT). Eight phenolic compounds were found in Salvia verticcilata L. Intense concentration of S. verticcilata L. has destroyed 97 % of living cells for Listeria innocua and 94.86% for E-coli. CONCLUSION This study shows that methanolic extracts of Salvia verticcilata L. is a potential source of natural antioxidants and antimicrobial agent and can form the basis for pharmacological studies.
Adolescents’ Intentions to Use Relationship Interventions by Demographic Group: Before and After a Relationship Education Curriculum

Although relationship education programs have been shown to be effective in promoting healthy relationships, participants are typically not from diverse backgrounds. Adolescent attitudes towards these programs and services were examined both before and after participation in a youth relationship education curriculum, Relationship Smarts Plus (RS+). The sample consisted of 1845 adolescents aged 11–18, 58% African American, 42% European American, 54.4% female, 45.6% male, from diverse family structures. Attitudes differed significantly between demographic groups at Time 1, where females and African Americans held more favorable attitudes. After RS+, attitudes significantly improved, on average, for European American males and African American females.
ADAPTIVE FUZZY CONTROL OF DIRECT-CURRENT MOTOR DEAD-ZONE SYSTEMS

An adaptive fuzzy control scheme is studied in this paper for the directcurrent (DC) motor systems with dead-zone input. The fuzzy logic systems are used to approximate the unknown functions in DC motor and based on the information of the parameters on the dead-zone, an adaptive fuzzy control approach is developed via backstepping design technique. Compared with the existing works for DC motor, less adjustable parameters are used in the approach. So, the computation load on line is reduced. The proposed scheme guarantees that the system output follows the reference signal to a small compact set and all the signals in the closed-loop are bounded. Simulation example is given to verify the effectiveness of the design method.
PaMSA: A Parallel Algorithm for the Global Alignment of Multiple Protein Sequences

Multiple sequence alignment (MSA) is a well-known problem in bioinformatics whose main goal is the identification of evolutionary, structural or functional similarities in a set of three or more related genes or proteins. We present a parallel approach for the global alignment of multiple protein sequences that combines dynamic programming, heuristics, and parallel programming techniques in an iterative process. In the proposed algorithm, the longest common subsequence technique is used to generate a first MSA by aligning identical residues. An iterative process improves the MSA by applying a number of operators that were defined in the present work, in order to produce more accurate alignments. The accuracy of the alignment was evaluated through the application of optimization functions. In the proposed algorithm, a number of processes work independently at the same time searching for the best MSA of a set of sequences. There exists a process that acts as a coordinator, whereas the rest of the processes are considered slave processes. The resulting algorithm was called PaMSA, which stands for Parallel MSA. The MSA accuracy and response time of PaMSA were compared against those of Clustal W, T-Coffee, MUSCLE, and Parallel T-Coffee on 40 datasets of protein sequences. When run as a sequential application, PaMSA turned out to be the second fastest when compared against the nonparallel MSA methods tested (Clustal W, T-Coffee, and MUSCLE). However, PaMSA was designed to be executed in parallel. When run as a parallel application, PaMSA presented better response times than Parallel T-Cofffee under the conditions tested. Furthermore, the sum-of-pairs scores achieved by PaMSA when aligning groups of sequences with an identity percentage score from approximately 70% to 100%, were the highest in all cases. PaMSA was implemented on a cluster platform using the C++ language through the application of the standard Message Passing Interface (MPI) library.
Comparison and Analysis Data-Centric Routing Protocols in Wireless Sensor Networks

Comparing protocols is one of the issues that had recently evaluated and its results significantly impact on choosing appropriate protocol. In this paper, wireless sensor networks will be presented and rout date-Centric protocol including Directed Diffusion, SPIN, Flooding, GBR and EAR will be evaluated and compared with each other. According to obtained results, it will be concluded that, considering that limited amount of energy of sensors in wireless sensor networks are the main limitation for planning protocol, and because EAR and GBR are better choices in the case of security, lifetime, consuming energy, then using these protocols for directing in wireless sensor networks will be advocated.
A Human REV7 Homolog That Interacts with the Polymerase ζ Catalytic Subunit hREV3 and the Spindle Assembly Checkpoint Protein hMAD2*

Widespread alteration of the genomic DNA is a hallmark of tumors, and alteration of genes involved in DNA maintenance have been shown to contribute to the tumorigenic process. The DNA polymerase ζ of Saccharomyces cerevisiae is required for error-prone repair following DNA damage and consists of a complex between three proteins, scRev1, scRev3, and scRev7. Here we describe a candidate human homolog of S. cerevisiae Rev7 (hREV7), which was identified in a yeast two-hybrid screen using the human homolog of S. cerevisiae Rev3 (hREV3). The hREV7 gene product displays 23% identity and 53% similarity with scREV7, as well as 23% identity and 54% similarity with the human mitotic checkpoint protein hMAD2. hREV7 is located on human chromosome 1p36 in a region of high loss of heterozygosity in human tumors, although no alterations of hREV3 or hREV7 were found in primary human tumors or human tumor cell lines. The interaction domain between hREV3 and hREV7 was determined and suggests that hREV7 probably functions with hREV3 in the human DNA polymerase ζ complex. In addition, we have identified an interaction between hREV7 and hMAD2 but not hMAD1. While overexpression of hREV7 does not lead to cell cycle arrest, we entertain the possibility that it may act as an adapter between DNA repair and the spindle assembly checkpoint.
Random Multi-access Algorithms - A Mean Field analysis

In this paper, using mean field techniques, we present a performance analysis of random back-off algorithms, such as the exponential back-off algorithm, in the case of a finite number of saturated sources. We prove that when the number of sources grows large, the system is decoupled, i.e., source behaviors become mutually independent. These results are applied in the specific case of exponential back-off algorithms, where the transient and stationary distributions of the back-off processes are explicitly characterized. This work provides a theoretical justification of decoupling arguments used by many authors, e.g. Bianchi [4], to analyze the performance of random algorithms in Wireless LANs.
Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1

Individuals with neurofibromatosis type 1 (NF1) frequently exhibit cognitive and motor impairments and characteristics of autism. The cerebellum plays a critical role in motor control, cognition, and social interaction, suggesting that cerebellar defects likely contribute to NF1-associated neurodevelopmental disorders. Here we show that Nf1 inactivation during early, but not late stages of cerebellar development, disrupts neuronal lamination, which is partially caused by overproduction of glia and subsequent disruption of the Bergmann glia (BG) scaffold. Specific Nf1 inactivation in glutamatergic neuronal precursors causes premature differentiation of granule cell (GC) precursors and ectopic production of unipolar brush cells (UBCs), indirectly disrupting neuronal migration. Transient MEK inhibition during a neonatal window prevents cerebellar developmental defects and improves long-term motor performance of Nf1-deficient mice. This study reveals essential roles of Nf1 in GC/UBC migration by generating correct numbers of glia and controlling GC/UBC fate-specification/differentiation, identifying a therapeutic prevention strategy for multiple NF1-associcated developmental abnormalities. DOI: http://dx.doi. org/10.7554/eLife.05151. 001
Real-time rendering of aerodynamic sound using sound textures based on computational fluid dynamics

In computer graphics, most research focuses on creating images. However, there has been much recent work on the automatic generation of sound linked to objects in motion and the relative positions of receivers and sound sources. This paper proposes a new method for creating one type of sound called aerodynamic sound. Examples of aerodynamic sound include sound generated by swinging swords or by wind blowing. A major source of aerodynamic sound is vortices generated in fluids such as air. First, we propose a method for creating sound textures for aerodynamic sound by making use of computational fluid dynamics. Next, we propose a method using the sound textures for real-time rendering of aerodynamic sound according to the motion of objects or wind velocity.
Crystal structure of 1-{(E)-[(3,4-dichlorophenyl)imino]methyl}naphthalen-2-ol

In the title compound, C17H11Cl2NO, the dihedral angle between the planes of the naphthalene ring system and the benzene ring is 28.88 (11)°. The main twist in the molecule occurs about the N—Cb (b = benzene ring) bond, as indicated by the C=N—Cb—Cb torsion angle of 31.0 (4)°. An intramolecular O—H⋯N hydrogen bond closes an S(6) ring. In the crystal, inversion dimers linked by pairs of very weak C—H⋯O interactions generate R 2 2(16) loops.
Reproducibility of cardiovascular and gas parameters in voluntary apnea related to apnea duration: A case study

The physiology and pathophysiology of voluntary apnea is an important issue not only for recreational and professional apnea diving, rescue and military diver, but also for the genesis of the involuntary sleep apnea. Numerous physiological mechanisms are involved to counteract the induced unbalance in the body's homeostasis. Even though cardiovascular effects are qualitatively similar in humans (such as diving reflex) the extent and temporal course can strongly vary from person to person. The present work discloses for the first time the behaviour of vital cardiovascular and gas parameters (in blood and air) as a novel function of the apnea duration. Blood pressure and heart rate increased for increasing apnea durations while pulsatile amplitude of the pulse wave in the finger and in the ear decreased. It is shown that carbon dioxide production per minute was quite stable independently of the voluntary apnea duration, whereas oxygen consumption per minute increased with increasing duration. The estimated respiratory quotient declined for longer apneas since the produced carbon dioxide in the lungs tended to increase slower than the consumed oxygen in the lungs. The oxygen saturation in blood exhibited a non-linear behaviour over the apnea duration, whereas the estimated partial pressure of oxygen decreased almost linearly over the duration. In addition, the reproducibility of cardiovascular parameters for apneas of different durations was quantified, given standardized conditions before apnea. Reproducibility, i.e. variation of a signal, for heart rate, systolic blood pressure and oxygen saturation was 10.6%, 8% and 1.4%, respectively, attained over different days of apnea recording. Higher variability in the heart rate and the blood pressure indicates their relevance as a regulatory parameter to counteract the physiological imbalance due to apnea.
Tracing the adoption of a management innovation labelled 'knowledge working' in a public sector agency in Scotland

This thesis investigates the process of adoption of management innovation in an organisational setting. It is based on primary research that explores and discusses in depth the introduction of a Knowledge Management programme (labelled ‘Knowledge Working’) within a distributed public sector agency in Scotland. The author was an employee of the organisation for a period of six years between the period 1999 and 2008. She latterly held the role of Knowledge Analyst and was a member of a task force recruited to implement Knowledge Working within the organisation. The primary research that this work addresses is: What is the process of adoption of a management innovation in an organisational setting? A qualitative case study strategy generates an account of the process of adoption through three phases (initiation; implementation; and outcomes), the episodes within each phase, and decision-making across all phases. Qualitative material covering a longitudinal timeframe (1995-2008) were collected for data analysis. These derived from electronic sources and participant observations assigned to an adoption timeline. The coding of the data facilitated the identification of phases and episodes of the management innovation under scrutiny. These were then analysed with reference to the extant literature. The study makes four contributions to knowledge. Three interrelated models (a model of decision-making; a combined adoption-decision-model; and a task force adoption-decision model) are theoretically significant because, to date, no attempt has been made: (1) to model decision-making for the process of adoption of management innovation (in general), or Knowledge Management; (2) to combine two of Rogers’ (2003) separate models (an innovation-adoption model and an innovation-decision model); and (3) to model decisions to consider when adopting task forces (in general), and those for implementing Knowledge Management.
WIND1 Promotes Shoot Regeneration through Transcriptional Activation of ENHANCER OF SHOOT REGENERATION1 in Arabidopsis[OPEN]

WIND1 directly activates the expression of another AP2/ERF transcription factor, ENHANCER OF SHOOT REGENERATION1, to promote callus formation and subsequent shoot regeneration. Many plant species display remarkable developmental plasticity and regenerate new organs after injury. Local signals produced by wounding are thought to trigger organ regeneration but molecular mechanisms underlying this control remain largely unknown. We previously identified an AP2/ERF transcription factor WOUND INDUCED DEDIFFERENTIATION1 (WIND1) as a central regulator of wound-induced cellular reprogramming in plants. In this study, we demonstrate that WIND1 promotes callus formation and shoot regeneration by upregulating the expression of the ENHANCER OF SHOOT REGENERATION1 (ESR1) gene, which encodes another AP2/ERF transcription factor in Arabidopsis thaliana. The esr1 mutants are defective in callus formation and shoot regeneration; conversely, its overexpression promotes both of these processes, indicating that ESR1 functions as a critical driver of cellular reprogramming. Our data show that WIND1 directly binds the vascular system-specific and wound-responsive cis-element-like motifs within the ESR1 promoter and activates its expression. The expression of ESR1 is strongly reduced in WIND1-SRDX dominant repressors, and ectopic overexpression of ESR1 bypasses defects in callus formation and shoot regeneration in WIND1-SRDX plants, supporting the notion that ESR1 acts downstream of WIND1. Together, our findings uncover a key molecular pathway that links wound signaling to shoot regeneration in plants.
Outflowing material in the zem = 4.92 BAL QSO SDSS J160501.21 011220.0 ⋆

We present the analysis of broad absorption lines (BALs) seen in the spectrum of the zem ≃4.92 QSO SDSS J160501.21-011220.0. Our high spectral resolution UVES spectrum shows two well detached absorption line systems at zabs= 4.685 and 4.855. The system at zabs= 4.855 covers the background source completely suggesting that the gas is located outside the broad emission line region. On the contrary the system at zabs= 4.685, which covers only on the continuum source, has a covering factor of the order of 0.9. Physical conditions are investigated in the BAL system at zabs= 4.855 using detailed photoionization models. The observed H i absorption line together with the limits on C ii and Si ii absorptions suggest that 16 < log N(H i) (cm −2 ) < 17 in this system. Comparison with models show that the observed column densities of N v , Si iv and C iv in this system require that nitrogen is underabundant by more than a factor 3 compared to silicon if the ionizing radiation is similar to a typical QSO spectrum. This is contrary to what is usually derived for the emission line gas in QSOs. We show that the relative suppression in the N v column density can be explained for Solar abundance ratios or abundance ratios typical of Starburst abundances if an ionizing spectrum devoid of X-rays is used instead. Thus, if the composition of BAL is like that of the emission line regions it is most likely that the cloud sees a spectrum devoid of X-rays similar to what we observe from this QSO. This is consistent with the fact that none of our models have high Compton optical depth to remove X-rays from the QSO. Similar arguments lead to the conclusion that the system at zabs= 4.685 as well is not Compton thick. Using simple Eddington arguments we show that the mass of the central black hole is ∼ 8 × 10 8 M⊙. This suggests that the accretion onto a seed black hole must have started as early as z = 11.
Values and justice

As we see the world around us, it is difficult not to be moved by the thought that there are huge injustices in the world in which we live. The difficult question that has to be addressed is how justice and injustice can be diagnosed and scrutinized. Even though we may be moved by an immediate sense of injustice, and that sense may well be very strong and even overpowering, it would be hard to deny that ultimately the diagnosis of justice and injustice must depend on our values – and in particular our examined and scrutinized values. This is where we need political philosophy in general and a theory of justice in particular. And that leads to the next question: what kind of a theory should a theory of justice be? What do we need from a theory of justice? I have tried to address these issues in a recent book, called The Idea of Justice, and I shall take the liberty of discussing some of the arguments presented there, before I go on to consider their implications for the relationship between values and justice. Mainstream theories of justice in contemporary political philosophy differ from each other in many respects, but they have a general approach in common – the approach of ‘social contract’ theory. The social contract approach was pioneered by Thomas Hobbes in the seventeenth century, and it has been the strongest influence in the analysis of justice from the eighteenth century to our own time. The distinguishing features of the approach include taking the characterization of ‘just institutions’ to be the principal – and often the only identified – task of the theory of justice. This way of seeing justice is woven in different ways around the idea of an imagined ‘social contract’ – a hypothetical contract about social organization that the people of a sovereign state can be imagined to have endorsed and accepted. Initiated by Thomas Hobbes, major contributions were made in this line of thinking in the period of European Enlightenment by John Locke, Jean-Jacques Rousseau and Immanuel Kant (even though the reach of Kant’s philosophical analysis is immensely larger than the rather limited domain of social contract theory). The contractarian approach has remained the dominant influence in contemporary political philosophy, led by the most prominent political philosopher of our time, John Rawls, whose classic book, A Theory of Justice published in 1971, presents a far-reaching statement of a particular version of the social contract approach to justice. The principal theories of justice in contemporary political philosophy, coming not only from Rawls but also from Robert Nozick, Ronald Dworkin, David Gauthier and others, share in common, explicitly or by implication, the idea of a social contract that identifies ideal social institutions (even though the substantive contents of their respective theories are different
A Model of Service Selection Based on Semantic and Collaboration

It is very important to select the service based on semantic and collaboration, collaboration will be the bridge between request and resource, by which we can get more useful relations and it is the foundation to select the service user satisfied. Using ontology to organize the resource and request, and by applying the description logic to descript the semantic, we propose a service selection model based on semantic and collaboration. In the model, we discuss the importance of the collaboration, and we research an algorithm to do collaboration between request ontology and resource ontology, by which we get new relations, and also, we discuss the service selection algorithm based on the semantic and collaboration. Finally, an example shows the processing of collaboration and service selection, which proved that our method is accessible.
Linkage disequilibrium between single nucleotide polymorphisms and hypermutable loci

Some diseases are caused by genetic loci with a high rate of change, and heritability in complex traits is likely to be partially caused by variation at these loci. These hypermutable elements, such as tandem repeats, change at rates that are orders of magnitude higher than the rates at which most single nucleotides mutate. However, single nucleotide polymorphisms, or SNPs, are currently the primary focus of genetic studies of human disease. Here we quantify the degree to which SNPs are correlated with hypermutable loci by examining a range of mutation rates. We use established population genetics theory to relate mutation rates to recombination rates and compare the theoretical predictions to simulations. Both simulations and theory agree that, at the highest mutation rates, almost all correlation is lost between a hypermutable locus and surrounding SNPs. The theoretical predictions break down as the mutation rate increases, and consequently differ widely from the simulated results. The simulation results suggest that some correlation remains between SNPs and hypermutable loci when mutation rates are on the lower end of the mutation spectrum. Consequently, in some cases SNPs can tag variation caused by some hypermutable loci. We also examine the linkage between SNPs and other SNPs and uncover ways in which the linkage disequilibrium of rare SNPs differs from that of hypermutable loci.