Miracle-dz/UniFAR-FTUs huggingface dataset:
Conduites suicidaires chez les adolescents et les jeunes adultes avec un trouble envahissant du développement

Les troubles du spectre de l’autisme (TSA) sont caracterises par des manifestations atypiques dans la socialisation et la communication, par des interets restreints et des stereotypies, et par des difficultes affectives et adaptatives. Les conduites suicidaires sont frequemment evoquees chez les adolescents et adultes avec un TSA, sans deficience intellectuelle (SDI). Mais la recherche clinique dans ce domaine est tres limitee et le diagnostic n’est pas envisage dans les services d’urgence. Parmi les facteurs de risque individuels de suicide chez les patients TSA, on retrouve la depression, les troubles anxieux et les antecedents familiaux de troubles affectifs. L’intimidation et les difficultes d’integration socio-professionnelle sont egalement des facteurs environnementaux rapportes. Des etudes en lien avec les caracteristiques cognitives permettraient d’explorer plus rigoureusement la phenomenologie du suicide chez les patients TSA.
The Unified Modeling Language User Guide

In The Unified Modeling Language User Guide, the original developers of the UML--Grady Booch, James Rumbaugh, and Ivar Jacobson--provide a tutorial to the core aspects of the language in a two-color format designed to facilitate learning. Starting with a conceptual model of the UML, the book progressively applies the UML to a series of increasingly complex modeling problems across a variety of application domains. This example-driven approach helps readers quickly understand and apply the UML. For more advanced developers, the book includes a learning track focused on applying the UML to advanced modeling problems.With The Unified Modeling Language User Guide, readers will:Understand what the UML is, what it is not, and why it is relevant to the development of software-intensive systemsMaster the vocabulary, rules, and idioms of the UML in order to "speak" the language effectivelyLearn how to apply the UML to a number of common modeling problemsSee illustrations of the UML's use interspersed with use cases for specific UML features, andGain insight into the UML from the original creators of the UML.
Monoamine Oxidase Inhibitors—Revisiting a Therapeutic Principle

Over more than 60 years, monoamine oxidase (MAO) inhibitors are available for therapy of central nervous diseases. Although they have shown to be efficacious specifically in the treatment of major depressive disorders and treatment-resistant depression, they became less a therapeutic choice for the physicians mostly due to severe side effects, such as liver failure and hypertensive crisis associated specifically with the first generation of inhibitors. Nevertheless, this class of drugs is still being used for treatment specifically as more selective and reversible inhibitors became available and will provide clinicians with additional treatment options. The current review revisits monoamine oxidase inhibitors and their potential in the treatment of human diseases, such as anxiety, depression, mood and personality disorders, and pain and introduces current ideas and developments.
Endocarditis due to Gemella haemolysans in a newly diagnosed multiple myeloma patient

An 87-year-old Caucasian woman with hypertension, diabetes mellitus type 2, and COPD was admitted with 1-week duration of back pain and weight gain. The physical examination revealed jugular venous distention, rales in the left lower lung field, and severe pitting edema over lower extremities. As workup for leukocytosis, blood cultures grew Gemella haemolysans. Subsequently, a transthoracic echocardiogram revealed vegetation on the non-coronary aortic leaflet and mild aortic stenosis. She was treated with ampicillin and gentamicin. After further investigation, the patient was diagnosed with plasma cell myeloma, the monoclonal lambda type. This is the first reported case of G. haemolysans endocarditis in a multiple myeloma patient.
Control of a series resonant converter by pulse density modulation

This paper presents the pulse density modulation (PDM) technique to control the half-bridge series resonant DC/DC converter. The switching devices of the converter when operates, work alternately only at a constant frequency or they are kept off. The control is exercised by modulating the train of pulses applied to the resonating network. The converter is operated at the constant frequency for a definite time decided by the controller and then the gate pulses are withdrawn during the rest of the time period. The time period is set by the frequency of a saw-tooth signal generator. The converter may be smoothly controlled from no-load to full-load range that is not possible by controlling the operating frequency or by pulse width modulation (PWM) or the half-bridge series resonant converter (SRC). The closed-loop controller is simulated in PSPICE. A laboratory prototype is also fabricated. The simulated and the experimental results match well confirming the validity and usefulness of the proposed technique.
Fabrication of monolithic integrated MEMS resonator with wet-release-monitoring array

In this work, a monolithic integrated MEMS resonator was fabricated and tested. Surface micromachining method was employed to fabricate the cantilever MEMS resonator after a standard 3 μm CMOS process. The wet release method with dilute HF solution was chosen and compared to the anhydrous HF vapor release process. A release-monitoring structure with polysilicon/Au cantilever array was used to determine the corrosion time of the sacrificial material. Results showed that the MOSFETs function well after proposed release process.
A 1.2 V 2.64 GS/s 8 bit 39 mW Skew-Tolerant Time-interleaved SAR ADC in 40 nm Digital LP CMOS for 60 GHz WLAN

A clock-skew tolerant 8-bit 16x time-interleaved (TI) semi-synchronous SAR ADC with switching-energy efficient hybrid resistive-capacitive DAC is presented that meets WiGig standard requirements with only background offset and gain calibrations. Skew tolerance is achieved by using a “correct-by-construction,” timing-calibration-free global bottom-plate sampling scheme. The ADC achieves a sampling rate of 2.64 GS/s while maintaining an ENOB of over 6 bits in the entire Nyquist band. The 40 nm LP CMOS design dissipates 39 mW from 1.2 V. The TI-SAR ADC characterized with an integrated receiver front-end achieves -21.44 dB EVM at sensitivity with a QAM16 signal.
Tests of Theory for Diel Variation in Salmonid Feeding Activity and Habitat Use

For many animals, selecting whether to forage during day or night is a critical fitness problem: at night, predation risks are lower but feeding is less efficient. Habitat selection is a closely related problem: the best location for nocturnal foraging could be too risky during daytime, and habitat that is safe and profitable in daytime may be unprofitable at night. We pose a theory that assumes animals select the combination of daytime and night activity (feeding vs. hiding), and habitat, that maximizes expected future fitness. Expected fitness is approximated as the predicted probability of surviving starvation and predation over a future time horizon, multiplied by a function representing the fitness benefits of growth. The theory's usefulness and generality were tested using pattern-oriented analysis of an individual-based model (IBM) of stream salmonids and the extensive literature on observed diel behavior patterns of these animals. Simulation experiments showed that the IBM reproduces eight diverse patterns observed in real populations. (1) Diel activity (whether foraging occurs during day and/or night) varies among a population's individuals, and from day to day for each individual. (2) Salmonids feed in shallower and slower water at night. (3) Individuals pack more tightly into the best habitat when feeding at night. (4) Salmonids feed relatively more at night if temperatures (and, therefore, metabolic demands) are low. (5) Daytime feeding is more common for life stages in which potential fitness increases more rapidly with growth. (6) Competition for feeding or hiding sites can shift foraging between day and night. (7) Daytime feeding is more common when food avail- ability is low. (8) Diel activity patterns are affected by the availability of good habitat for feeding or hiding. We can explain many patterns of variation in diel foraging behavior without assuming that populations or individuals vary in how inherently nocturnal or diurnal they are. Instead, these patterns can emerge from the search by individuals for good trade- offs between growth and survival under different habitat and competitive conditions.
Nutrients, Signals, and Photosynthate Release by Symbiotic Algae (The Impact of Taurine on the Dinoflagellate Alga Symbiodinium from the Sea Anemone Aiptasia pulchella)

Exogenous concentrations of 10 [mu]M to 1 mM of the nonprotein amino acid taurine stimulated photosynthate release from the dinoflagellate alga Symbiodinium, which had been freshly isolated from the sea anemone Aiptasia pulchella. Photosynthate release, as induced by taurine and animal extract, was metabolically equivalent at both concentrations in that they (a) stimulated photosynthate release to the same extent and (b) induced the selective release of photosynthetically derived organic acids. A complex mixture of amino acids at 75 mM also promoted photosynthate release, but the release rate was reduced by 34% after the omission of taurine (3 mM) from the mixture, suggesting that much of the effect of amino acids was largely attributable to taurine. Exogenous 14C-labeled taurine was taken up by the cells, and more than 95% of the internalized 14C was recovered as taurine, indicating that taurine-induced photosynthate release was not dependent on taurine metabolism. Both taurine uptake and taurine-induced photosynthate release by Symbiodinium exhibited saturation kinetics, but with significantly different Km values of 68 and 21 [mu]M, respectively. The difference in Km values is compatible with the hypothesis that Symbiodinium has a taurine signal transducer that is responsible for photosynthate release and is distinct from the taurine transporter.
Substrate integrated waveguide cross-coupled filters for witeless applications

This paper presents a pseudo-elliptic substrate integrated cross-coupled filter with two finite transmission zeros based on quasi-ridged resonators. The filter was designed and simulated at central frequency of about 5.8 GHz. It has a bandwidth of 400 MHz and exhibits good stopband rejection of 25 dB.
Detection of period-3 behavior in genomic sequences using singular value decomposition

Manydigital signal processing techniques have beenusedtoautomatically distinguish theprotein coding regions (exons) fromnon-coding regions (introns) inaDNAsequence. Recently, Auto-regressive (AR) technique hasbeenused forthedetection of3periodicty present inprotein coding regions of genomic sequences. The. sequence length, average spacing between coding regions, andaverage coding region length arethemainfactors thataffect the performance ofanyprediction method Inthis paper, wepropose theuseofSingular Value Decomposition (SVD) methodfor thedetection ofperiod-3 behavior in DNA sequences. Results showthatSVDmethod outperforms theARtechnique.
Does ambient temperature interact with air pollution to alter blood pressure? A repeated-measure study in healthy adults

Objectives: Both low temperature and high air pollution have been associated with an increased risk of cardiovascular events, which could be predicted by increased arterial blood pressure (BP) within short periods. However, whether exposures to temperature and air pollution simultaneously may have interactive effects on BP has been unknown. We investigated this potential interaction during 460 repeated visits in 39 healthy university students in the context of traffic-related air pollution. Methods: Study participants in the Healthy Volunteer Natural Relocation study underwent repeated BP measurements for 12 occasions under three exposure scenarios in Beijing, China, in 2010–2011. We used generalized linear mixed-effects models to estimate exposure effects. Results: Decreasing temperature was associated with significant increases in BP. There were significant interactions between temperature and traffic-related air pollutants (particulate matter with an aerodynamic diameter ⩽2.5 &mgr;m, organic carbon, elemental carbon and nitrogen dioxide) on BP (P < 0.05 for all interaction tests). The estimated increases in SBP and DBP were 4.9 mmHg [95% confidence interval (CI) 2.9–6.8] and 3.7 mmHg (95% CI 2.3–5.1) at high elemental carbon level (≥median), and were −1.3 mmHg (95% CI −6.3 to 3.6) and 0.7 mmHg (95% CI −2.8 to 4.2) at low elemental carbon level (<median) per 10°C decrease in daily minimum temperature. We also found stronger air pollution effects on BP at low temperature levels (<median) than at high temperature levels (≥median). Conclusion: Low temperature and high air pollution may act synergistically to increase BP in healthy adults. Our findings may have potential implications for prevention of cardiovascular events associated with increased BP among high-risk individuals.
On the minimum principle and dynamic programming for hybrid systems with low dimensional switching manifolds

A class of hybrid systems with both autonomous and controlled switchings and jumps is considered where switching manifolds corresponding to autonomous switchings and jumps are allowed to be codimension k submanifolds in ℝn with 1≤k≤n. Optimal control problems associated to this class of hybrid systems are studied where in addition to running and terminal costs, costs associated to switching between discrete states are allowed. Statements of the Hybrid Minimum Principle and Hybrid Dynamic Programming as well as their relationship are presented in this general setting and an illustrative example is provided.
Design and Implementation of a Multi-Area Distributed Crawler Based on Skipnet-YL Network

Refering to single area crawler model based on p2p-chord network, designed and implemented a multi-area crawler model based on own design Skipnet-YL network which based on Skipnet protocol. It use better performance router protocol Skipnet-YL and the idea of SuperNodes and OSPF. Sequentially, it can solve the problem of low performance and the large of communication traffic during increasing nodes. After testing and analysing this model, this paper found out its deficiency, then put forward improved solutions for shortage. Eventually, it looked forward into future work.
A clustering-based preprocessing on feeder power in presence of photovoltaic power plant

The equivalent power of feeder, as one of the inputs of chronological simulation of a power network in presence of a large scale photovoltaic power plant, needs some preprocessing in order to reduce simulation time. The Fuzzy C-means, Gustafson Kessel, K-means and K-medoid methods are applied to find a few numbers of representatives for the equivalent power of feeder. The proposed techniques are validated and optimal number of clusters is found out by means of several clustering validity indices. A comparison with a conventional technique is made on the score of invariant separation index.
Measurement of Epitaxial NbN/AlN/NbN Tunnel Junctions With a Low Critical Current Density at Low Temperature

Superconducting qubit circuits require high quality low critical current density Josephson tunnel junctions. We have developed high quality epitaxial NbN/AlN/NbN tunnel junctions with critical current density, Jc, ranging from as low as a few A/cm2 to a few tens of kA/cm2. In this work, we measured current-voltage characteristics for junctions with a Jc ~ 32 A/cm2 in the temperature range from 17 mK to above 6.7 K. All the junctions are in good quality and have a high gap voltage (>; 5.5 mV). We found that the junctions' sub-gap resistances were temperature dependent above 2.5 K and saturated at temperatures below 2.5 K. A junction sub-gap leakage current Ir of about 23 pA was measured. The voltage noise power spectral density for 3 junctions with different sizes has been measured at the base temperature of 17 mK with the junctions biased above the gap voltage. The spectral densities clearly show 1/f behavior at low frequency and are proportional to the junction's linear dimension.
ACTIVITY AND CHARACTERIZATION OF A LOW MOLECULAR FRACTION PRESENT IN HUMAN AMNIOTIC FLUID WITH BROAD SPECTRUM ANTIBACTERIAL ACTIVITY

The isolation of a low molecular weight fraction from amniotic fluid with broad spectrum antimicrobial activity is reported. This fraction consists of a family of peptides whose bactericidal activity is zinc dependent and can be inhibited by phosphate. Peptides are present in early gestation in low concentration increasing in amount from about 28 weeks gestation when antimicrobial activity becomes detectable in whole amniotic fluid. A simple bacteriological assay for this material is described. Its relation to the occurrence of perinatal infection is discussed.
Optimal spare capacity design for various protection switching methods in ATM networks

With the employment of very high capacity transmission systems in high-speed broadband networks (B-ISDN, broadband integrated services digital network), based upon the asynchronous transfer mode (ATM), the consequences of a link failure have increased, since even during a short disconnection a large volume of data is lost. These networks can be made safer against failure, if in the case of a transmission link outage the affected traffic is routed over still intact network parts. This paper describes various protection switching methods for ATM networks and presents mathematical models which can be used to determine globally optimal restoration paths and to dimension spare capacities in the network. Finally, the results are discussed and the various methods are compared.
Variation of lateral doping&#8212;A new concept to avoid high voltage breakdown of planar junctions

In this paper a new concept for high voltage planar junctions is presented. The necessary widening of the space charge region at the end of the junction is obtained by implantation through small openings in the oxide mask and subsequent drive-in, leading to a controlled smeared-out dopant distribution. Experimental results show the validity of the concept.
Design Metrics as an Aid to Software Maintenance: An Empirical Study

This paper proposes a technique for identifying areas within system designs that may be prone to future corrective or preventative maintenance activity. From that, this paper presents a set of measures that can be applied at the design stage of software development to support the production of more maintainable software. The measures are founded on the theories of coupling and control flow and have been empirically validated on a medium-sized industrial project. The results have shown that the control flow and export coupling measures are significantly good predictors of the future error rate. Copyright © 1999 John Wiley & Sons, Ltd.
Changes in Lumbar Movement in People With Low Back Pain Are Related to Compromised Balance

Study Design: Comparing people with and without low back pain (LBP). Objectives. This study aimed to investigate lumbar spine movement and the quality of postural recovery in response to unexpected postural perturbation in people with LBP. Summary of Background Data. People with chronic LBP tend to use lumbar spine motion less frequently for postural control than pain-free individuals, and after voluntary arm movement, they need more time and a greater number of postural adjustments to regain postural equilibrium. We hypothesize that motion of the lumbar spine is altered in people with chronic LBP, and this would be associated with compromised control of postural stability in response to unexpected perturbation. Methods. The response to a sudden load imposed by a weight dropped into a box held in the hands was studied in 11 individuals with chronic LBP and matched controls. Lumbopelvic motion was recorded with an electromagnetic motion analysis system. Time to recover balance was calculated from ground reaction forces. Results. People with LBP had a delayed initiation of lumbar spine flexion (angular displacement) (Control = 44.9 [25.1] ms, LBP = 90.2 [42.3] ms, P < 0.001) and took longer to regain postural stability (Control = 460.4 [123.4] ms, LBP = 761.0 [194.2] ms, P < 0.001) after the perturbation. Conclusion. These data provide further evidence that the quality of balance control is compromised in LBP patients and that this is associated with poor use of spinal motion as a component of the postural strategy.
The kinase DYRK 1 A reciprocally regulates the differentiation of Th 17 and regulatory T cells

The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified a novel role for the dual specificity tyrosinephosphorylation-regulated kinase DYRK1A in regulating this balance. Inhibition of DYRK1A enhances Treg differentiation and impairs Th17 differentiation without affecting known pathways of Treg/Th17 differentiation. Thus, DYRK1A represents a novel mechanistic node at the branch point between commitment to either Treg or Th17 lineages. Importantly, both Treg cells generated using the DYRK1A inhibitor harmine and direct administration of harmine itself potently attenuate inflammation in multiple experimental models of systemic autoimmunity and mucosal inflammation. Our results identify DYRK1A as a physiologically relevant regulator of Treg cell differentiation and suggest a broader role for other DYRK family members in immune homeostasis. These results are discussed in the context of human diseases associated with dysregulated DYRK activity. DOI: 10.7554/eLife.05920. 00
Adaptation of Francisella tularensis to the Mammalian Environment Is Governed by Cues Which Can Be Mimicked In Vitro

ABSTRACT The intracellular bacterium Francisella tularensis survives in mammals, arthropods, and freshwater amoeba. It was previously established that the conventional media used for in vitro propagation of this microbe do not yield bacteria that mimic those harvested from infected mammals; whether these in vitro-cultivated bacteria resemble arthropod- or amoeba-adapted Francisella is unknown. As a foundation for our goal of identifying F. tularensis outer membrane proteins which are expressed during mammalian infection, we first sought to identify in vitro cultivation conditions that induce the bacterium's infection-derived phenotype. We compared Francisella LVS grown in brain heart infusion broth (BHI; a standard microbiological medium rarely used in Francisella research) to that grown in Mueller-Hinton broth (MHB; the most widely used F. tularensis medium, used here as a negative control) and macrophages (a natural host cell, used here as a positive control). BHI- and macrophage-grown F. tularensis cells showed similar expression of MglA-dependent and MglA-independent proteins; expression of the MglA-dependent proteins was repressed by the supraphysiological levels of free amino acids present in MHB. We observed that during macrophage infection, protein expression by intracellular bacteria differed from that by extracellular bacteria; BHI-grown bacteria mirrored the latter, while MHB-grown bacteria resembled neither. Naïve macrophages responding to BHI- and macrophage-grown bacteria produced markedly lower levels of proinflammatory mediators than those in cells exposed to MHB-grown bacteria. In contrast to MHB-grown bacteria, BHI-grown bacteria showed minimal delay during intracellular replication. Cumulatively, our findings provide compelling evidence that growth in BHI yields bacteria which recapitulate the phenotype of Francisella organisms that have emerged from macrophages.