Miracle-dz/UniFAR-FTUs huggingface dataset:
Purification of coagulation factor VIII by immobilized metal affinity chromatography

Factor VIII (FVIII) is a glycoprotein that plays an essential role in blood coagulation cascade. Purification of plasma‐derived coagulation FVIII by direct application of plasma to a chromatographic column is a method of choice. Anion exchange column is a very powerful method because FVIII is strongly adsorbed, resulting in good activity recovery and high purification factor. However, vitamin‐K‐dependent coagulation factors coelute with FVIII. In the present study, we report the separation of vitamin‐K‐dependent coagulation proteins from FVIII using immobilized metal affinity chromatography (IMAC) with Cu2+ as the metal ligand. Plasma was directly loaded to a Q Sepharose Big Beads column, and FVIII was recovered with 65% activity and a purification factor of approximately 50 times. Then, the Q Sepharose eluate was applied to the IMAC–Cu2+ column, and FVIII was eluted with 200 mM imidazole, with up to 85% recovery of activity. The mass recovery in this fraction was less than 10% of the applied mass of protein. Vitamin‐K‐dependent proteins elute with imidazole concentrations of lower than 60 mM. Because of the difference in affinity, FVIII could be completely separated from the vitamin‐K‐dependent proteins in the IMAC column.
Cold Powering Performance of the First 2 m Nb3Sn DS11T Twin-Aperture Model Magnet at CERN

For the upgrade of the LHC during the long shutdown 2 and for the HL-LHC upgrade during the long shutdown 3, a few 15 m 8.3 T Nb–Ti main dipole magnets are foreseen to be replaced by two 11 T Nb3Sn dipoles, 5.5 m long each. After the production and test of three single aperture models at CERN, the first 2-m-long twin-aperture model has been tested. The model was used to exploit the limits of the model in terms of quench performance and protection. The protection studies included the heater efficiency studies and hotspot temperature studies. In this paper, the performance of the magnet DP101 in terms of training behavior, detection, and protection, and other cold powering test will be presented and discussed.
A Study of Closing Adaptive Control in Electronically Controlled Intelligent Contactor

This paper presents studies into the reduction of electrical contact bounce for an electronically controlled and intelligent new-type contactor. The controlling approach is based on dynamically tracking the position trajectory of movable electromagnet and then timing coil energized periods. The applied coil voltage is modulated by means of PWM (pulse width modulation) the period of the power element driving signals. Controlling approach is verified through the new-type contactor prototype which is constructed in our laboratory and some useful results are obtained. By observing the experimental results, it proving that our proposed control approach is actually feasible
A Dual Band Belt Antenna

A novel wearable antenna for wireless communications is presented in this paper. This paper has discussed the possibility of employing a belt buckle as an antenna, bringing benefits such as removability and the ability to hand portable wireless devices from the belt itself. The antenna consists of a belt buckle, hinge, denim waist band and electrical connections. The antenna was fed by a microstrip transmission line on the denim substrate with the antenna placed on the other side of the textile band. The prototype achieves wide band, dual frequency operation and is able to cover the 2.45GHz and 5.25 GHz bands necessary for Bluetooth/WLAN and IEEE 802.11 standards.
Association of HIV, Hepatitis C Virus, and Liver Fibrosis Severity With the Enhanced Liver Fibrosis Score.

BACKGROUND Liver disease is common during human immunodeficiency virus (HIV) infection, but valid serum fibrosis markers are lacking. We hypothesize that HIV monoinfection and HIV/hepatitis C virus (HCV) coinfection is associated with an enhanced liver fibrosis (ELF) score higher than that for uninfected controls and examine whether this association is affected by factors other than liver injury. METHODS The association of HIV and HIV/HCV coinfection with the ELF score was evaluated using multivariable regression after controlling for transient elastography-measured liver stiffness and traditional and HIV-related factors in a cross-sectional analysis of 297 women. RESULTS HIV/HCV-coinfected and HIV-monoinfected women had higher median ELF scores than controls (9.6, 8.5, and 8.2, respectively). After adjustment for demographic, behavioral, and metabolic factors and for inflammatory markers, HIV/HCV coinfection remained associated with a 9% higher ELF score (95% confidence interval [CI], 5%-13%), while the association of HIV monoinfection was substantially attenuated (1% higher ELF score; 95% CI, -2% to 4%). After further adjustment for liver stiffness, HIV/HCV coinfection remained associated with 6% higher levels (95% CI, 3%-10%). In HIV/HCV-coinfected and HIV-monoinfected women, higher liver stiffness values were associated with higher ELF scores, as were older age and a nadir CD4(+) T-cell count of <200 cells/mm(3). CONCLUSIONS Our findings suggest that the ELF score can be used to assess liver fibrosis severity in HIV-infected women. However, higher ELF scores may reflect extrahepatic fibrosis in HIV-infected patients with a history of severe immunosuppression or advanced age.
Ultrastructure and histochemistry of the tegument of juvenile paramphistomes during migration in Indian ruminants

Abstract The tegument of juvenile Paramphistomum epiclitum and Fischoederius elongatus (Paramphistomidae: Digenea) resembles those of other digeneans. Seven types of papillae were observed, mostly on the oral and acetabular surfaces, and increase in number during migration. Also evident are two types of secretory body (T1 and T2) which are synthesized separately in tegumental cytons underlying the syncytium. Exocytosis of T2 bodies occurs at the apical membrane and appears to contribute to a fibrous glycocalyx. The tegumental syncytium lining the pharynx and acetabulum is thinner and has a higher capacity for vacuolation than the general tegument. These may represent important sites for osmoregulation. The absence of mitochondria from the tegument in migrating juveniles suggests limited involvement in energy demanding processes. Pigmentation of the subtegument is first evident in mature cercariae and is progressively eliminated during migration.
Propagation-based Morphometry in an ex vivo mouse embryo atlas - assessment and validation

The increasing use of genetically modified mice has highlighted the need for effective phenotyping methods. Propagation-based morphometry (PBM) is an emerging technique enabling non-invasive and rapid acquisition of volumetric data using an average population atlas for morphometric analysis. Thus, PBM shows promise for combining high-throughput µMR imaging of late-gestation embryos with high-throughput analysis. We present the first study to assess and validate the accuracy of volumes generated via PBM in an ex vivo mouse embryo atlas comprising three different groups. Preliminary results show promise towards the broad applicability of this technique for phenotyping mutant mouse models.
A method to compute reactive power margins with respect to v

A method of computing the reactive power margin-i.e. the difference between the maximum reactive load and the corresponding base case value-for a given set of load buses of a power system is proposed. This margin is aimed at assessing the system robustness with respect to voltage collapse. The corresponding collapse point is directly obtained as the solution of an optimization problem with the load increase as the objective, the nonoptimized loads as equality constraints, and the generator reactive limits as inequality constraints. The CRIC electrical decoupling yields a voltage-only problem. The latter is solved using the Newton approach and a procedure is given to deal with the inequality constraints efficiently. A simple illustrative example and simulation results obtained on the Belgian 520-bus, 41-generator system are given. >
Circulation of Coxiella burnetii in a Naturally Infected Flock of Dairy Sheep: Shedding Dynamics, Environmental Contamination, and Genotype Diversity

ABSTRACT Q fever is a worldwide zoonosis caused by Coxiella burnetii. Domestic ruminants are considered to be the main reservoir. Sheep, in particular, may frequently cause outbreaks in humans. Because within-flock circulation data are essential to implementing optimal management strategies, we performed a follow-up study of a naturally infected flock of dairy sheep. We aimed to (i) describe C. burnetii shedding dynamics by sampling vaginal mucus, feces, and milk, (ii) assess circulating strain diversity, and (iii) quantify barn environmental contamination. For 8 months, we sampled vaginal mucus and feces every 3 weeks from aborting and nonaborting ewes (n = 11 and n = 26, respectively); for lactating females, milk was obtained as well. We also sampled vaginal mucus from nine ewe lambs. Dust and air samples were collected every 3 and 6 weeks, respectively. All samples were screened using real-time PCR, and strongly positive samples were further analyzed using quantitative PCR. Vaginal and fecal samples with sufficient bacterial burdens were then genotyped by multiple-locus variable-number tandem-repeat analysis (MLVA) using 17 markers. C. burnetii burdens were higher in vaginal mucus and feces than in milk, and they peaked in the first 3 weeks postabortion or postpartum. Primiparous females and aborting females tended to shed C. burnetii longer and have higher bacterial burdens than nonaborting and multiparous females. Six genotype clusters were identified; they were independent of abortion status, and within-individual genotype diversity was observed. C. burnetii was also detected in air and dust samples. Further studies should determine whether the within-flock circulation dynamics observed here are generalizable.
A reachability-based theoretical framework for modeling and querying complex probabilistic graph data

Probabilistic graph data arise in a plethora of modern applications ranging from sensor networks to RDF query tools and IP-network monitoring systems. This is due to the fact that probabilistic graphs are able to capture and model uncertainty and imprecision that characterize datasets populating the above-mentioned scenarios. On the basis of this amenity, a large family of proposals devoted to model and query probabilistic graph data appeared, with alternate fortune. Nevertheless, few of these approaches address a challenge that is, indeed, relevant for graph data management research, i.e. the issue of modeling and querying complex probabilistic graph data, which, contrary to state-of-the-art initiatives, expose an inherently-complex nature, beyond common confidence-interval-based data models. Aimed by the goal of filling this gap, in this paper we propose a novel reachability-based theoretical framework for modeling and querying complex probabilistic graph data, by also providing the definition of some meaningful classes of graph queries that allow us to extract useful knowledge from such graphs in terms of algebra-aware (sub-)graphs, plus related (query) algorithms and semantics.
Breast Cancer in African Americans

Purpose: The purpose of this synthesis is to explore the experience of the transition from cancer patient to survivor in African Americans with breast cancer, addressing the risk/ protective factors that have an influence on successful transition using the social ecological model. Methods: The investigator searched CINAHL, PubMed, and PsycInfo databases. Articles were assessed for content addressing risk and protective factors of transition in African American breast cancer survivorship. Eleven research articles were obtained and synthesized. Results: Risk and protective factors exist at all levels of the social ecological model. Emotional issues are prevalent after the cessation of cancer treatment, enhanced by the lack of social support in this population. Spirituality was shown to be present in many levels as a protective factor during this period. Conclusions and Implications for Practice: The entrance to survivorship represents a time of increased stressors and subsequent coping. Through careful identification of influencing factors, health care providers can develop strategies to attenuate the emotional distress and negative complications of the transition specific to this vulnerable population. Illuminating the experiences of African American women during this transition period provides insight into the interventional needs during and after the cessation of breast cancer treatment.
A Human–Robot Co-Manipulation Approach Based on Human Sensorimotor Information

This paper aims to improve the interaction and coordination between the human and the robot in cooperative execution of complex, powerful, and dynamic tasks. We propose a novel approach that integrates online information about the human motor function and manipulability properties into the hybrid controller of the assistive robot. Through this human-in-the-loop framework, the robot can adapt to the human motor behavior and provide the appropriate assistive response in different phases of the cooperative task. We experimentally evaluate the proposed approach in two human–robot co-manipulation tasks that require specific complementary behavior from the two agents. Results suggest that the proposed technique, which relies on a minimum degree of task-level pre-programming, can achieve an enhanced physical human–robot interaction performance and deliver appropriate level of assistance to the human operator.
The Expression of EGFR Family Ligands in Breast Carcinomas

Expression of EGF, HB-EGF, TGF-oc, HRG-oc, HRG-f1, and HRG-P3 in 100 frozen breast carcinoma materials was immunohistochemically studied. Among these tumors, 67% were positive for EGF, 53% for HB-EGF, 57% for TGF-a, 60% for HRGax, 53% for HRG-31, and 63% for HRG-f3 in the neoplastic epithelial cells. No significant associations between expression of the growth factors and clinicopathological features like tumor size, histologic grade, node status, ploidy, ER status, and c-erbB-4 expression were observed, with the exceptions that significant relations were present between EGF expression and tumor size (p = 0.01) and between HRG-P3 expression and node status (p =0.02). The expressions of these growth factors showed no associationwith cancer-specific survival by the Kaplan Meier analysis.
A neoteric method based on PWM ON PWM scheme with buck converter for torque ripple minimization in BLDC drive

In this paper a detailed analysis on torque ripples of brushless dc drives in both commutation and conduction region is given. A neoteric method for the elimination of torque ripples in BLDC motor by employing PWM_ON_PWM scheme has been introduced by the addition of a buck converter in the entrance of the inverter. PWM_ON_PWM strategy is mainly applied to compensate the commutation torque ripples during commutation period caused by commutation current and it cannot entirely remove the torque ripples that are resulted from current introducing in the turn off phase. Closed loop operation using PWM_ON_PWM scheme with buck converter is used for eliminating the ripples in both conduction and commutation region. The duty cycle of PWM is regulated by using wave function of back EMF and for speed regulation PI controller is used. Simulation results are used for revealing circuit validation.
Caractérisation et diversité des mécanismes du syndrome de mortalité affectant les juvéniles de Crassostrea gigas

Les maladies infectieuses sont souvent etudiees a l'aide d'approches reductionnistes alors qu'elles sont fortement influencees par de nombreux facteurs hotes et environnementaux en interaction. Ainsi, de nombreuses maladies d’etiologie complexe restent difficiles a caracteriser. En developpant une approche holistique pour aborder la complexite de l'interaction, (i) nous avons dechiffre les interactions complexes sous-jacentes au syndrome de mortalite des huitres du Pacifique chez les juveniles d’huitres Crassostrea gigas, la principale espece d'huitre exploitee dans le monde et (ii) nous avons valide le mecanisme de pathogenese quel que soit l’environnement infectieux et le genotype de l’huitre. En utilisant une experience d’infection ecologiquement realiste combinee a des analyses moleculaires (metabarcoding, transcriptomique, et suivi des agents pathogenes) et histologiques sur des familles d'huitres aux susceptibilites contrastees a la maladie, nous avons demontre que la maladie est causee par une infection multiple avec comme premiere etape necessaire l’infection des cellules immunocompetentes de l’huitre (les hemocytes) par OsHV-1µvar. La replication du virus induit un etat immunodeprime de l’huitre qui conduit a une septicemie par des bacteries pathogenes opportunistes entrainant la mort des huitres. En identifiant les interactions intra-hotes entre les microorganismes et l'immunite de l'hote, cette etude dechiffre le code du syndrome de mortalite des huitres du Pacifique et fournit d'importantes donnees pour la conception de mesures prophylactiques et de programmes de selection d'huitres resistantes au syndrome de mortalite. Nous pensons qu'une telle approche de la biologie des systemes pourrait etre appliquee pour dechiffrer d'autres maladies multifactorielles qui affectent des especes d'invertebres non modeles dans le monde entier.
A greedy-based oversampling approach to improve the prediction of mortality in MERS patients

Predicting mortality of Middle East respiratory syndrome (MERS) patients with identified outcomes is a core goal for hospitals in deciding whether a new patient should be hospitalized or not in the presence of limited resources of the hospitals. We present an oversampling approach that we call Greedy-Based Oversampling Approach (GBOA). We evaluate our approach and compare it against the standard oversampling approach from a classification perspective on real dataset collected from the Saudi Ministry of Health using two popular supervised classification methods, Random Forests and Support Vector Machines. Our results demonstrate that our approach outperforms the other standard approach from a classification perspective by giving the highest accuracy with statistical significance on the 20 simulations of the real dataset.
Apache Avro , etc Data Aggregation Messaging Systems Queueing Systems Publish-Subscribe Messaging Stream Processing Data Stream Processing Engines Complex Event-Processing Frameworks IoT Hubs Delivery Web Interfaces Dashboards

Under several emerging application scenarios, such as in smart cities, operational monitoring of large infrastructure, wearable assistance, and Internet of Things, continuous data streams must be processed under very short delays. Several solutions, including multiple software engines, have been developed for processing unbounded data streams in a scalable and efficient manner. More recently, architecture has been proposed to use edge computing for data stream processing. This paper surveys state of the art on stream processing engines and mechanisms for exploiting resource elasticity features of cloud computing in stream processing. Resource elasticity allows for an application or service to scale out/in according to fluctuating demands. Although such features have been extensively investigated for enterprise applications, stream processing poses challenges on achieving elastic systems that can make efficient resource management decisions based on current load. Elasticity becomes even more challenging in highly distributed environments comprising edge and cloud computing resources. This work examines some of these challenges and discusses solutions proposed in the literature to address them.
Notice of RetractionService Innovation Performance Evaluation in Service Enterprise - Based on Wuhan Telecom Best Tone Center

Service innovation management has only recently emerged as an academic discipline. Studies on innovation performance evaluation in the service sector, however, have received little attention from academic researchers. By reviewing relevant literature, this paper defines the service innovation performance and sets up a service innovation performance evaluation (SIPE) index system in service enterprise considering the characteristics of service innovation, with the theoretical guide of Balanced Scorecard. Then, this paper applies the performance evaluation system of service innovation to measure the service innovation performance of Wuhan Telecom Best Tone Center (WHTBTC), and proposes several management suggestions.
The Itemized NIHSS Scores Are Associated With Discharge Disposition in Patients With Minor Stroke

Background and purpose: The ability of the National Institutes of Health Stroke Scale (NIHSS) score to predict functional outcome in minor stroke is controversial. In this study, we examined the association of itemized NIHSS score with discharge outcome. Methods: We included all patients with final diagnosis of stroke with an NIHSS score of 0 to 5 untreated with thrombolysis enrolled in the “Stroke Warning Information and Faster Treatment” trial. Individual components of the NIHSS score were the primary predictors. Poor outcome was defined as not being discharged home. Logistic regression was used to identify predictors of outcome. Results: A total of 861 patients met the inclusion criteria; 162 (19%) were not discharged home. In multivariable regression, predictors of discharge other than home were age (odds ratio [OR] = 1.02 per year increase, P < .001) and total NIHSS score (OR per unit increase in the NIHSS = 1.51, P < .001). Motor (OR = 2.32, P < .001), level of consciousness (LOC; OR = 6.62, P = .004), and ataxia (OR = 3.10, P < .001) were also associated with not being discharged home. Motor (area under the curve [AUC] 0.623) appeared to be more predictive of poor outcome than ataxia (AUC 0.569) and LOC (AUC 0.517). The total NIHSS had a fair correlation with discharge outcome (AUC 0.683). Conclusion: Total and itemized NIHSS components have a fair correlation with outcome in minor stroke highlighting the importance of other measures of stroke severity for clinical trials.
The Political Economy of Exchange Rate Regime Duration : A Survival Analysis

This paper examines the role that political, institutional and economic factors played in exchange rate regime duration in 49 developing countries within the time period 1974-2000. Set in the framework of survival analysis, I characterize and model the times to exit for a fixed exchange rate regime using a Cox model. The empirical analysis shows that exchange rate regime choice is not a purely theoretical issue, but strongly depends on partisan and institutional incentives such as the political colour of the government in power, the number of veto players and the degree of central bank independence. JEL classification: E61, F31, F33
Efficient calculation of effective material parameters in metamaterials using FDTD and a modal approach

We present an efficient modal approach in combination with the Finite Integration Technique (FIT) - a generalized FDTD-like method - to analyze resonant structures. Rather than performing time-consuming time-stepping of long transients, the eigenmodes of the spatial discretization operators are utilized to extract frequency-domain parameters of the simulated devices. As an application we calculate averaged material parameters of recently proposed so-called metamaterials, which show a distinctive resonant behavior with negative permittivity and permeability in a certain frequency range.