Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of U5 snRNP in pre‐mRNA splicing

The current model for the function of the U5 small nuclear ribonucleoprotein particle (snRNP) in the spliceosome proposes that U5 carries binding sites for the 5′ and 3′ exons, allowing the spliceosome to ‘tether’ the 5′ exon intermediate produced by the first catalytic step and align it with the 3′ exon for the second step. Functional analysis of U5 snRNA in cis‐spliceosomes has provided support for this model, and data from nematode and trypanosome splicing systems suggest that U5 or a U5‐like snRNA performs a similar role in trans‐splicing.
Software solution design for application of reliability centered maintenance in preventive maintenance plan

The implementation of Reliability Centered Maintenance into Preventive Maintenance Plan scheduling is one of the possible paths towards cost reductions in the fields of diagnostics and operating personnel. There is also the assumption of maintaining acceptable reliability of individual devices within the entire network. The devices to be considered suitable for application of RCM concern network elements present in sufficient quantities, supported with enough experience relevant to maintenance and with the data obtained through operative measurements and protection available. This data set forms ideal fundamentals for analysis and status assessment of a particular device. Provided the current status of a system element is known and it future development can be expected, the maintenance interval can be adjusted — giving priority to PMP applicable to devices in unsatisfactory condition and postponement of PMP for devices in good condition. This paper describes the design of software for PMP priority assessment pursuant to the RCM method with respect to priority assigned to electric power supply and evaluation of consequences for customers.
The management of knee pain in primary care: factors associated with consulting the GP and referrals to secondary care.

OBJECTIVES To investigate the treatment of knee pain in primary care and the factors associated with consulting general practitioners (GPs) and referrals to specialist services. METHODS Individuals with knee pain were identified through postal questionnaires sent to patients aged 50 and over from two GP practices in southeast London. Patients with knee pain were then invited to the department, where demographic, clinical and service use data were collected. Participants also completed measures of pain, function, handicap and illness beliefs. RESULTS From the 2940 questionnaires that were sent out, the response rate was 34%. Of these, 49% reported experiencing knee pain in the previous 12 months. Two hundred and thirty-one patients with knee pain attended the department. One hundred and thirty-four (58%) had seen their GP about their knee pain, with 50 (37%) referred on to specialist services. Compared with non-consulters, consulters had more severe disease and higher levels of disability and handicap, and believed the condition was more severe and had major consequences on their lives. Those referred to specialist care had higher levels of handicap and also believed the condition was more severe, with major consequences on their lives, than those not referred. CONCLUSION In this sample nearly half of those who reported knee pain had not seen their GP and were self-managing their condition. A mixture of physical, social and psychological factors predicted visits to GPs and rates of referral to secondary care. Patient perceptions about knee pain were important predictors of both consultations and referrals, highlighting the need to address both physical and psychosocial factors in relation to help-seeking.
Examining the Reliability and Validity of Clinician Ratings on the Five-Factor Model Score Sheet

Despite substantial research use, measures of the five-factor model (FFM) are infrequently used in clinical settings due, in part, to issues related to administration time and a reluctance to use self-report instruments. The current study examines the reliability and validity of the Five-Factor Model Score Sheet (FFMSS), which is a 30-item clinician rating form designed to assess the five domains and 30 facets of one conceptualization of the FFM. Studied in a sample of 130 outpatients, clinical raters demonstrated reasonably good interrater reliability across personality profiles and the domains manifested good internal consistency with the exception of Neuroticism. The FFMSS ratings also evinced expected relations with self-reported personality traits (e.g., FFMSS Extraversion and Schedule for Nonadaptive and Adaptive Personality Positive Temperament) and consensus-rated personality disorder symptoms (e.g., FFMSS Agreeableness and Narcissistic Personality Disorder). Finally, on average, the FFMSS domains were able to account for approximately 50% of the variance in domains of functioning (e.g., occupational, parental) and were even able to account for variance after controlling for Axis I and Axis II pathology. Given these findings, it is believed that the FFMSS holds promise for clinical use.
HARD X-RAY EMISSION FROM SH 2‐104: A NuSTAR SEARCH FOR GAMMA-RAY COUNTERPARTS

We present NuSTAR hard X-ray observations of Sh 2–104, a compact H ii region containing several young massive stellar clusters (YMSCs). We have detected distinct hard X-ray sources coincident with localized VERITAS TeV emission recently resolved from the giant gamma-ray complex MGRO J2019+37 in the Cygnus region. Fainter, diffuse X-rays coincident with the eastern YMSC in Sh2-104 likely result from the colliding winds of a component star. Just outside the radio shell of Sh 2–104 lies 3XMM J201744.7+365045 and a nearby nebula, NuSTAR J201744.3+364812, whose properties are most consistent with extragalactic objects. The combined XMM-Newton and NuSTAR spectrum of 3XMM J201744.7+365045 is well-fit to an absorbed power-law model with cm−2 and a photon index . Based on possible long-term flux variation and the lack of detected pulsations (≤43% modulation), this object is likely a background active galactic nucleus rather than a Galactic pulsar. The spectrum of the NuSTAR nebula shows evidence of an emission line at E = 5.6 keV, suggesting an optically obscured galaxy cluster at z = 0.19 ± 0.02 (d = 800 Mpc) and LX = 1.2 × 1044 erg s−1. Follow-up Chandra observations of Sh 2–104 will help identify the nature of the X-ray sources and their relation to MGRO J2019+37. We also show that the putative VERITAS excess south of Sh 2–104, is most likely associated with the newly discovered Fermi pulsar PSR J2017+3625 and not the H ii region.
The use of unit root and Box-Jenkins in Amman Stock Exchange (ASE)

This paper aims at examining the level of the efficiency of Amman Stock Exchange (ASE) on weak form, semi-strong form and strong form levels from January 2008 to December 2014. The paper concludes that there is a significant prediction performance of all ASE indices of the Jordanian market by using Box-Jenkins estimation. This result was confirmed by unit-root test since the return series for the five Jordanian indices failed to prove unit root.
Analysis of Human Resource Management Practices and Firm Efficiency of Consumer Goods Manufacturing Firms in Kenya

Manufacturing sector is important to the Kenyan economy, employing 13% of total workforce in the formal sector and 1.4 million people in the informal sector. Despite the importance, its contribution to the regional market is low at 7% export and GDP remains stagnant at 10% since 1960s. This has raised the concerns about Kenyan manufacturing sector’s performance in relation to firm efficiency. Previous studies in Kenya have focused on strategic human resource management practices and firm performance. While the HRM practices - firm efficiency relationship may enhance improved productivity, no research has been undertaken in consumer goods manufacturing firms in Kenya. The objective was to establish the relationship between human resource management practices and firm efficiency of consumer goods manufacturing firms in Kenya. Drawing from Resource Based theory, it was conceptualized that the independent and dependent variables are HRM practices and firm efficiency respectively. A cross sectional survey design and population of 65 firms were used. It was a census study with response at 76.9%. The results revealed that there is significant association between HRM practices and firm efficiency with most significant association being on material incentives and firm efficiency with R2 of 66.9% (β=.303, p<0.01), indicating that material incentives account for 30.3% of variance in efficiency. Conclusions are that among the firms, HRM practices predict firm efficiency. It is recommended that the firms’ efforts should be directed on HRM practices in order to enhance firm efficiency. Contrary to prior research, this study has revealed that HRM practices, affect firm efficiency.
Households’ Savings Behaviour of Dindigul District, Tamilnadu – A Comprehensive Analysis (With Special Reference to Thoppampatti Block)

The research work undertaken on the Households savings behaviour of Dindigul District, TamilNadu- A comprehensive Analysis. The main objective of the research is to examine savings behaviour of the rural Households and factors influencing savings behaviour. The research study conducted is descriptive in nature. Interview schedule method is used as an instrument. The Multistage stratified random sampling is used and the sample size is 99.The tools used are percentage analysis, chi square analysis, cross tabulation correlation and regression. The study revealed that the savings behaviour in Thoppampatti block is satisfactory because most of the households are saving in various banks and their borrowings are less. The researcher suggests that the various organisations should create the awareness about various sectors.
Inspiration des sondages d'opinion pour réduire la latence en filtrage collaboratif

Le filtrage collaboratif est l'une des approches les plus populaires des systemes de recommandation. En filtrage collaboratif, le systeme cherche a estimer les preferences de l'utilisateur actif en exploitant les preferences (les notes) des utilisateurs similaires a cet utilisateur actif : ses voisins. Le filtrage collaboratif fait face au probleme de latence : il ne peut recommander un nouvel item a des utilisateurs tant que cet item n'a pas ete note un nombre suffisant de fois. Pour diminuer ce probleme de latence, nous proposons une approche a base de mentors s'inspirant des sondages d'opinion. Un mentor est un utilisateur fiable et representatif, sur qui l'on peut compter. La connaissance des notes (opinions) des mentors sur les nouveaux items permet d'estimer les notes de la population entiere. Nous montrons que, sur le corpus que nous avons utilise, certaines methodes de selection des mentors requierent les notes de seulement 6 mentors pour estimer les notes de la population entiere, avec une erreur faible. Ainsi, lorsqu'un nouvel item est integre dans le systeme, seules 6 notes sont requises pour faire des recommandations de bonne qualite a l'ensemble de la population.
The interactional basis of hypnotic experience: on the relational dimensions of hypnosis.

Abstract The ubiquitous interactional basis of hypnosis remains neglected and poorly understood. Vignettes from clinical practice and research are presented to illustrate the significance of hypnotic relational factors and their internal representations. A descriptive theoretical framework is formulated enumerating 4 relational dimensions: (a) transference phenomena in which previous object relationships are enacted; (b) a goal-oriented working alliance comprised of “rational” and “irrational” expectations about the efficacy of hypnotic procedure and its participants; (c) a symbiotic or fusional alliance in which the hypnotist is experienced as a purely internal figure; and (d) a realistic contemporary relationship. Each dimension is considered as it subjectively operates within hypnosis, and a case example is employed to compare the psychotherapeutic operation of these diinensions in waking and hypnotic contexts. Implications of the interactional framework are discussed and further empirical and clinical.
Habitual physical activity in children and adolescents during school and free days.

PURPOSE The purpose of this study was to analyze habitual physical activity (HPA) of boys and girls from primary school to high school. METHODS One hundred eighty-two schoolchildren and teenagers (6-20 yr) were studied at primary school (PS, N= 64), junior high school (JHS, N= 67), and senior high school (SHS, N= 51). HR was continuously monitored during the whole week to assess HPA during school days and free days. Total physical activity (TPA), low physical activity (LPA), moderate physical activity (MPA), and vigorous physical activity (VPA) were evaluated from the time spent each day above 50%HR reserve (HRR), below 50%HRR, between 50% and 70%HRR, and above 70%HRR, respectively. RESULTS During school days, TPA decreased by 69% in male subjects (P< 0.05) and by 36% in female subjects (N= 0.058) from PS to SHS. In contrast, TPA did not vary significantly during free days (male subjects, PS: 62 +/- 37 min x d, SHS: 63 +/- 67 min x d; female subjects, PS: 75 +/- 59 min x d, SHS: 62 +/- 44 min x d ). Gender differences were only observed during school days at PS for TPA (male subjects: 121 +/- 37 min x d vs female subjects: 92 +/- 44 min x d, P< 0.05) and VPA (male subjects: 38 +/- 21 min x d vs female subjects: 18 +/- 12 min x d, P< 0.05). Male and female subjects were more inactive during free days than during school days at PS (P< 0.05). No effect of the type of day and gender was observed for all indices of HPA at high schools. CONCLUSIONS Our results highlight the importance of taking into account the type of day (school day vs free day) in the analysis of children and adolescents' HPA.
The synthetic polyphenol tert-butyl-bisphenol inhibits myoglobin-induced dysfunction in cultured kidney epithelial cells

Abstract Rhabdomyolysis caused by severe burn releases extracellular myoglobin (Mb) that accumulates in the kidney and urine (maximum [Mb] ∼ 50 μM) (termed myoglobinuria). Extracellular Mb can be a pro-oxidant. This study cultured Madin-Darby-canine-kidney-Type-II (MDCK II) cells in the presence of Mb and tested whether supplementation with a synthetic tert-butyl-polyphenol (tert-butyl-bisphenol; t-BP) protects these renal cells from dysfunction. In the absence of t-BP, cells exposed to 0–100 μM Mb for 24 h showed a dose-dependent decrease in ATP and the total thiol (TSH) redox status without loss of viability. Gene expression of superoxide dismutases-1/2, haemoxygenase-1 and tumour necrosis factor increased and receptor-mediated endocytosis of transferrin and monolayer permeability decreased significantly. Supplementation with t-BP before Mb-insult maintained ATP and the TSH redox status, diminished antioxidant/pro-inflammatory gene responses, enhanced monolayer permissiveness and restored transferrin uptake. Overall, bolstering the total antioxidant capacity of the kidney may protect against oxidative stress induced by experimental myoglobinuria.
Perceptions Concerning The Inclusion Of Public Policy Materials In Engineering Curriculum

In previous research, we surveyed approximately seventy undergraduate and graduate engineering students in order to understand their perspectives on the inclusion of public policy coursework within their curriculum. We sought to determine whether these students thought that it was of value to gain an understanding of public policy as it related to their discipline. We found that many of these students did value such knowledge. We also found that the more senior students and the students with work experience overwhelmingly valued such material. As a follow-up to this research, we surveyed approximately one hundred engineers in a variety of hiring positions in industry to determine their view on the inclusion of public policy in an engineering curriculum. Among the questions included in the survey, we asked, “Do you believe that engineering students should be exposed to public policy issues as part of their education? ” We also addressed a number of other issues, including: 1) How do these engineers define public policy? 2) Should the inclusion of such policy issues be part of a standalone course or integrated into existing courses? 3) Who should teach this material? 4) Could such knowledge help a student advance in their career? and 5) Would you favor hiring students with educational background in public policy? In this paper, we report on the findings of this survey. Of note, we found statistically significant differences based on the engineering discipline and on the job title of the survey participant.
Analysis of the dynamical behaviour of the EEG rhythms during a test of sustained attention

In clinical routine, the evaluation of sustained attention is often performed analyzing behavioral data collected during specific tests. It is not common to match such analyses with a detailed examination of the subject's simultaneous electroencephalographic (EEG) activity, and particularly its frequency content. In this study, 9 healthy volunteers underwent a modified Conners' CPT test, while their EEG was contemporarily recorded. Spectral power was calculated for each of the recorded EEG signals, with particular attention to frequency bands that are traditionally reported in literature. Then compressed spectral array (CSA) sequence of spectra was plotted, and the analysis of the variability of the rhythms was carried out. Evaluation of the obtained results shows that the nine subjects shared a progressive backshift of alpha rhythm during the accomplishment of the CPT test. Moreover, beta and gamma activities were stronger in the right than in the left hemisphere. An intense and widespread decrease in EEG spectral power during test performing became visible in many subjects. Statistical analysis provided evidence that EEG activity correlates with the test behavioral results in many cerebral areas. For this reason, we encourage further investigations of the combined employment of tests and EEG recording during the clinical assessment of sustained attention performance.
Market-Orientation and Its Impact on the Performance of Asia Insurance Company in Kerman Province

The key of successes by service providers can be found in their market-orientation. These are organizations which pay more attention to customers and rivals and attempt to provide services with the highest quality. Present paper has studied experimentally the relationship between market-orientation and performance of agencies and brokers of Asia Insurance Company in Kerman province. Here, the scale of market-orientation in service sector is applied. The methodology is field study and the tool to gather information is questionnaire. Factors analysis shows that there are four hidden aspects in the title of market-orientation: customer-orientation, rival-orientation, organizational responsiveness, propensity to customer satisfaction. Findings suggest that customer–orientation and propensity to customer satisfaction have remarkable impacts on performance relative to other aspects. Rival-orientation has lower impact on performance and organizational responsive has an inconsistency relationship with performance.
Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer†

Abstract Background: Frequently, subjects offered colonoscopy due to symptoms of colorectal neoplasia are diagnosed with diverticula. The symptoms may, however, also be related to extra-colonic neoplasia. The present retrospective study evaluated a possible association between increased levels of predefined biomarkers in subjects diagnosed with diverticula and risk of developing a primary malignant disease. Methods: During 2004/2005, about 4509 subjects were included in a multicenter study with collection of blood samples before bowel endoscopy. The aim was to evaluate a relation between the protein biomarkers CEA, TIMP-1, CA19-9 and YKL-40 and findings at endoscopy. Diverticula were diagnosed in 1021 subjects. By 31 December 2012, subjects who had developed primary malignancy were identified retrospectively and relation between biomarker levels at endoscopy and risk of developing primary malignancy was calculated. The relation with the four biomarkers was divided into three groups: 0 = none increased; 1 = one increased and 2 = two or more increased. Results: In the observation period, 148 subjects developed a primary malignant disease. Univariable analyzes of the biomarker levels showed that CEA, TIMP-1 and CA19-9 were significantly associated with development of primary malignancy. A multivariable analysis showed that increased levels were associated with development of malignancy (p < 0.0001). The 1- and 5-year cumulative risks of being diagnosed with a primary malignancy were: group 0: 1.1%/5.5%; group 1: 4.2%/10.1% and group 2: 11.4%/18.8%, respectively. Conclusion: Increased levels of CEA, TIMP-1 and CA19-9 at endoscopy with findings of diverticula were associated with a significantly increased risk of being diagnosed with a subsequent primary malignant disease.
A parking lot induction method based on Dijkstra algorithm

By analyzing the drivers' main consideration about how to choose a parking space, this paper is committed to path optimization of parking lot by modified Dijkstra algorithm. The main factors that impact drivers choosing optimal parking lot are driving distance, the number of vehicle moved along motorway, and the occupancy situations of free parking space. Finally, an example would be analyzed to verify the feasibility of the method.
Prevention, Detection and Management of Coronary Artery Disease in Minority Females.

BACKGROUND AND SIGNIFICANCE Heart disease is the leading cause of death for women living in the United States; this disease claims more female lives than all cancers combined. Additionally, according to the Centers of Disease Control data between the years 1979 and 2006, while cardiac-related mortality among men decreased significantly, only a modest decline was found among women. This disparity is greatest among minority females including Blacks and Hispanics who have an even greater prevalence of CVD and its risk factors. PREVENTION There are several risk factors for coronary artery disease (CAD). Modifiable risk factors include: tobacco smoking, hypertension, diabetes, hyperlipidemia, obesity and physical inactivity. The prevention of CAD is grounded in decreasing or removing these modifiable risk factors. DETECTION Accurately diagnosing CAD is dependent on an accurate assessment of the patient's pre-test probability to determine the best diagnostic approach to pursue. The patient's functional status, resting EKG and cardiac risk factors also assist in determining the best non-invasive cardiac test to pursue. MANAGEMENT The goals and mainstay in the management of minority females with stable CAD includes surveillance for CAD symptoms, management of hypertension, diabetes mellitus and hyperlipidemia, as well as encouraging healthy habits. CONCLUSION Heart disease remains the leading cause of death in minority females. Providers must be diligent to aggressively decrease patients' cardiovascular risk and, when patients do present with cardiovascular symptoms, providers must be aggressive in accurately diagnosing and treating these patients to decrease cardiac morbidity and mortality.