Miracle-dz/UniFAR-FTUs huggingface dataset:
Design and rationale of the MyHeartMate study: a randomised controlled trial of a game-based app to promote behaviour change in patients with cardiovascular disease

Introduction Recurrence of cardiac events is common after a first event, leading to hospitalisations and increased health burden. Patients have difficulties achieving the lifestyle changes required for secondary prevention and access to secondary prevention programs is limited. This study aims to evaluate the impact of a game-based mobile app, MyHeartMate, which is designed to motivate engagement in secondary prevention behaviours for cardiovascular risk factors. Methods and analysis The MyHeartMate study is a randomised controlled trial with 6-month follow-up and blinded assessment of the primary outcome. Participants (n=394) with coronary heart disease will be recruited from hospitals in metropolitan Sydney and randomly allocated to standard care or the MyHeartMate app intervention. The intervention group will receive the app, which uses game techniques to promote engagement and lifestyle behaviour change for secondary prevention. The primary outcome is difference between the groups in physical activity (metabolic equivalent of task minutes/week) at 6 months. Secondary outcomes include change in low-density lipoprotein cholesterol, systolic blood pressure, medication adherence, body mass index, waist circumference, mood and dietary changes at 6 months. Data on app engagement, and patient perspectives of usability and acceptability, will also be analysed. Ethics and dissemination The study has received ethics approval from Northern Sydney Local Health District Human Research Ethics Committee. The study findings will be disseminated via peer-reviewed publications and presentation at international scientific meetings/conferences. Trial registration number ACTRN12617000869370; Pre-results.
Insole-Based Estimation of Vertical Ground Reaction Force Using One-Step Learning With Probabilistic Regression and Data Augmentation

An insole-based estimation of the vertical ground reaction force (vGRF) is proposed as an alternative to costly force plates for the evaluation of pathological gait. However, machine learning techniques for estimation still rely on the use of force plates. Moreover, measuring plural walking steps in order to prevent overfitting induces fall risks and physically taxes the patients. Therefore, this paper presents an accessible and efficient learning scheme for the insole-based estimation of vGRF. In this system, we employ a low-cost scale as an alternative to force plates. Then, we use Gaussian process regression (GPR) to learn a model in order to estimate vGRF without overfitting of small-sized data sets corrupted by measurement errors and noise of the devices. In addition, we propose a “one-step learning” scheme based on a probabilistic data augmentation. This approach augments actual measurements of a minimum (just one) walking step to a virtual data set for plural steps by considering their typical variability between steps. In experiments, the GPR models learned from two walking steps estimated vGRF with mean errors of 8% or under for entire/local magnitudes. Moreover, the learning from one step with probabilistic augmentation enhanced the estimation accuracy.
Metaphor Interpretation Using Word Embeddings

We suggest a model for metaphor interpretation using word embeddings trained over a relatively large corpus. Our system handles nominal metaphors, like"time is money". It generates a ranked list of potential interpretations of given metaphors. Candidate meanings are drawn from collocations of the topic ("time") and vehicle ("money") components, automatically extracted from a dependency-parsed corpus. We explore adding candidates derived from word association norms (common human responses to cues). Our ranking procedure considers similarity between candidate interpretations and metaphor components, measured in a semantic vector space. Lastly, a clustering algorithm removes semantically related duplicates, thereby allowing other candidate interpretations to attain higher rank. We evaluate using different sets of annotated metaphors, with encouraging preliminary results.
Traditional clinical training combined with high-fidelity simulation-based activities improves clinical competency and knowledge among nursing students on a maternity nursing course.

BACKGROUND Providing adequate and quality clinical training to student nurses is a major issue in nursing education. In the Middle East, this issue is more prominent because providing intimate healthcare to women in maternity nursing, especially by male nursing students, remains a challenge. PURPOSE This study compared the effects of a combination of traditional clinical training with high-fidelity simulation (TCT+HFS) activities vs TCT alone on the clinical competency and knowledge among students enrolled in a maternity nursing course in a Middle Eastern public university. METHOD A quasi-experimental research design was adopted in the study. The sample consisted of 74 students (40 in the TCT group and 34 in the TCT+HFS group) from a cohort of nursing students in a Middle Eastern university. The Creighton Competency Evaluation Instrument and a 29-item, researcher-designed knowledge scale was used to measure the relevant outcomes. RESULTS No significant difference was observed in the knowledge (F = 1.064, P = 0.306) or clinical competency scores (F = 0.168, P = 0.683) between the TCT+HFS group and the TCT group. CONCLUSION Substituting 25% of the clinical hours with HFS may yield similar learning outcomes (knowledge and clinical competency) as TCT.
Effects of an anesthetic mixture of medetomidine, midazolam, and butorphanol and antagonism by atipamezole in rabbits

Medetomidine (MED), midazolam (MID), and butorphanol (BUT) mixed anesthetic (MMB) has been used in laboratory animals since ketamine (KET) was designated as a narcotic in Japan in 2007. We previously reported that MMB produced anesthetic effects in mice and rats. We also demonstrated the efficacy of atipamezole (ATI), an antagonist of MED produced a quick recovery from anesthesia. Anesthetics have various anesthetic effects among different animal species. However, there is little information regarding its effects in rabbits. In the present study, we examined anesthetic effects of MMB compared to KET and xylazine mixed anesthetic (KX). We examined the antagonistic effects of ATI by intramuscular (IM) or intravenous (IV) injection in rabbits. We used the anesthetic score to measure surgical anesthetic duration and recovery time from anesthesia. During the experiments, we measured heart rate, respiratory rate, O2-saturation, and blood pressure. We found there were no significant differences in anesthetic duration and recovery time between MMB and KX. There were no significant differences in heart rate after administration of MMB or KX. Systolic blood pressure at 10 min after administration of MMB was higher than that of KX. The antagonistic effect of ATI by IV injection worked faster than that by IM injection. Overall, MMB is a useful drug that can induce similar anesthetic effects to KX and has an antagonist of ATI that makes rabbits quickly recover from anesthesia. These results may contribute to the welfare of laboratory animals, especially rabbits.
A Non-Dicer RNase III and Four Other Novel Factors Required for RNAi-Mediated Transposon Suppression in the Human Pathogenic Yeast Cryptococcus neoformans

The human pathogenic yeast Cryptococcus neoformans silences transposable elements using endo-siRNAs and an Argonaute, Ago1. Endo-siRNAs production requires the RNA-dependent RNA polymerase, Rdp1, and two partially redundant Dicer enzymes, Dcr1 and Dcr2, but is independent of histone H3 lysine 9 methylation. We describe here an insertional mutagenesis screen for factors required to suppress the mobilization of the C. neoformans HARBINGER family DNA transposon HAR1. Validation experiments uncovered five novel genes (RDE1-5) required for HAR1 suppression and global production of suppressive endo-siRNAs. The RDE genes do not impact transcript levels, suggesting the endo-siRNAs do not act by impacting target transcript synthesis or turnover. RDE3 encodes a non-Dicer RNase III related to S. cerevisiae Rnt1, RDE4 encodes a predicted terminal nucleotidyltransferase, while RDE5 has no strongly predicted encoded domains. Affinity purification-mass spectrometry studies suggest that Rde3 and Rde5 are physically associated. RDE1 encodes a G-patch protein homologous to the S. cerevisiae Sqs1/Pfa1, a nucleolar protein that directly activates the essential helicase Prp43 during rRNA biogenesis. Rde1 copurifies Rde2, another novel protein obtained in the screen, as well as Ago1, a homolog of Prp43, and numerous predicted nucleolar proteins. We also describe the isolation of conditional alleles of PRP43, which are defective in RNAi. This work reveals unanticipated requirements for a non-Dicer RNase III and presumptive nucleolar factors for endo-siRNA biogenesis and transposon mobilization suppression in C. neoformans.
Opioid-induced constipation: a narrative review of therapeutic options in clinical management

Pain therapy often entails gastrointestinal adverse events. While opioids are effective drugs for pain relief, the incidence of opioid-induced constipation (OIC) varies greatly from 15% to as high as 81%. This can lead to a significant impairment in quality of life, often resulting in discontinuation of opioid therapy. In this regard, a good doctor-patient relationship is especially pivotal when initiating opioid therapy. In addition to a detailed history of bowel habits, patient education regarding the possible gastrointestinal side effects of the drugs is crucial. In addition, the bowel function must be regularly evaluated for the entire duration of treatment with opioids. Furthermore, if the patient has preexisting constipation that is well under control, continuation of that treatment is important. In the absence of such history, general recommendations should include sufficient fluid intake, physical activity, and regular intake of dietary fiber. In patients of OIC with ongoing opioid therapy, the necessity of opioid use should be critically reevaluated in terms of an with acceptable quality of life, particularly in cases of non-cancer pain. If opioids must be continued, lowering the dose may help, as well as changing the type of opioid. If these measures do not suffice, the next step for persistent OIC is the administration of laxatives. If these are ineffective as well, treatment with peripherally active μ-opioid receptor antagonists should be considered. Enemas and irrigation are emergency measures, often used as a last resort.
PREhabilitation for improving QUality of recovery after ELective cardiac surgery (PREQUEL) study: protocol of a randomised controlled trial

Introduction Frailty is a multidimensional syndrome in which multiple small physiological deficits accumulate gradually, resulting in a loss of physiological reserve and adaptability, putting a patient that is exposed to a stressor at a higher risk of adverse outcomes. Both pre-frailty and frailty are associated with poor patient outcomes and higher healthcare costs. The effect of a prehabilitation programme and standard care on the quality of recovery in pre-frail and frail patients undergoing elective cardiac surgery will be compared. Method and analysis A single-centre, superiority, stratified randomised controlled trial with a blinded outcome assessment and intention-to-treat analysis. Pre-frail and frail patients awaiting elective coronary artery bypass graft, with or without valvular repair/replacement, will be recruited. 164 participants will be randomly assigned to either prehabilitation (intervention) or standard care (no intervention) groups. The prehabilitation group will attend two sessions/week of structured exercise (aerobic and resistance) training, supervised by a physiotherapist, for 6–10 weeks before surgery with early health promotion advice in addition to standard care. The standard care group will receive the usual routine care (no prehabilitation). Frailty will be assessed at baseline, hospital admission and at 1 and 3 months after surgery. The primary outcomes will be participants' perceived quality of recovery (15-item Quality of Recovery questionnaire) after surgery (day 3), days at home within 30 days of surgery and the changes in WHO Disability Assessment Schedule 2.0 score between baseline and at 1 and 3 months after surgery. Secondary outcomes will include major adverse cardiac and cerebrovascular events, psychological distress levels, health-related quality of life and healthcare costs. Ethics and dissemination The Joint CUHK-NTEC Clinical Research Ethics Committee approved the study protocol (CREC Ref. No. 2017.696 T). The findings will be presented at scientific meetings, in peer-reviewed journals and to study participants. Trial registration number ChiCTR1800016098; Pre-results.
A low cost open droplet-based microfluidic devices on printed circuit board

Microfluidics technology dominates laboratory facilities as microscale devices where large scale of laboratories equipment no longer needed. These microfluidic devices are very useful in many applications including clinical diagnostics and cell based analysis, where micro to nano liter range of samples can be used to run the bioassays. Recently, various study of digital microfluidic devices have been done and the fabrication techniques used have shown to be expensive. In this paper, a low cost open plate droplet-based digital microfluidic devices using Electrowetting on Dielectrics (EWOD) technique is fabricated and experimentally demonstrated. The proposed system features a 2×4 electrodes array on a standard FR4 printed circuit board (PCB) technology. In this method, open droplet-based microfluidic device is formed from copper substrates with a gap width of 203.2 μm between the inter-electrode. By replacing the expensive dielectric and hydrophobic coatings materials such as parylene-C and Teflon-AF, saran wrap (polyethylene film) and cooking oil has been used, respectively. Additionally, the system has been tested for open EWOD configuration by dispensing 2.5 μL of distilled water. Thus, a low cost of fabrication method enables the system setup of digital microfluidics without the need of clean room facilities.
Synthesis of 68Ga-Labeled Biopolymer-based Nanoparticle Imaging Agents for Positron-emission Tomography

Aim: The purpose of this study was to develop a folate receptor-targeted 68Ga-labeled agent for the detection of cancer cells in mouse models of ovarian cancer by dual positron-emission tomography (PET) and magnetic resonance imaging (MRI). Moreover, we aimed to develop a controlled biopolymer-based chemistry that enables linking metal-binding (here Ga-68) chelators. Materials and Methods: The nanoparticle (NP) agent was created by self-assembling of folic acid-modified polyglutamic acid and chelator-modified chitosan followed by radiolabeling with 68Ga (III) ions (68Ga-NODAGA-FA). The structure of modified biopolymers was characterized by spectroscopy. Particle size and mobility were determined. Results: Significant selective binding of NPs was established in vitro using folate receptor-positive KB and - negative MDA-MB-231 cell lines. In vivo tumor uptake of folate-targeted 68Ga3+-radiolabeled NPs was tested using subcutaneous tumor-bearing CB17 SCID mice models. PET/MR dual modalities showed high tumor uptake with 6.5 tumor-to-muscle ratio and NP localization. Conclusion: In vivo results supporting the preliminary in vitro tests demonstrated considerably higher 68Ga-NODAGA-FA nanoparticle accumulation in KB tumors than in MDA-MB-231 tumors, thereby confirming the folate receptor-mediated uptake of this novel potential PET imaging agent.
Aluminosilicate Nanotubes Embedded Polyamide Thin Film Nanocomposite Forward Osmosis Membranes with Simultaneous Enhancement of Water Permeability and Selectivity

Nanocomposite membranes are strongly desired to break a trade-off between permeability and selectivity. This work reports new thin film nanocomposite (TFN) forward osmosis (FO) membranes by embedding aluminosilicate nanotubes (ANTs) into a polyamide (PA) rejection layer. The surface morphology and structure of the TFN FO membranes were carefully characterized by FTIR, XPS, FESEM and AFM. The ANTs incorporated PA rejection layers exhibited many open and broad “leaf-like” folds with “ridge-and-valley” structures, high surface roughness and relatively low cross-linking degree. Compared with thin film composite (TFC) membrane without ANTs, the TFN membrane with only 0.2 w/v% ANTs loading presented significantly improved FO water permeability, selectivity and reduced structural parameters. This promising performance can be mainly contributed to the special ANTs embedded PA rejection layer, where water molecules preferentially transport through the nanochannels of ANTs. Molecular dynamic simulation further proved that water molecules have much larger flux through the nanotubes of ANTs than sodium and chloride ions, which are attributed to the intrinsic hydrophilicity of ANTs and low external force for water transport. This work shows that these TFN FO membranes with ANTs decorated PA layer are promising in desalination applications due to their simultaneously enhanced permeability and selectivity.
Implication of atypical supraclavicular F18-fluorodeoxyglucose uptake in patients with breast cancer: Association between brown adipose tissue and breast cancer

It has been reported that F18-fluorodeoxyglucose (FDG) uptake in the neck and supraclavicular lesions represents activated brown adipose tissue (BAT). In the present study, the association between BAT activity, detected by FDG-positron emission tomography (PET), and the clinicopathological features of patients with breast cancer was investigated. The cases of 156 consecutive patients with breast cancer who underwent FDG-PET preoperatively were analyzed. The distribution and intensity of atypical FDG uptake in the neck and/or supraclavicular region was reviewed. The intensity was graded as follows: 1, weak; 2, moderate; and 3, intense. Among the 156 patients, 70 (44.9%) exhibited grade 1 intensity, 65 (41.7%) exhibited grade 2 intensity and 21 (13.5%) exhibited grade 3 intensity. The intensity of FDG was significantly associated with human epidermal growth factor receptor 2 (HER2) expression and progesterone expression. Among the 156 patients, 6 (3.8%) had recurrent disease. Multivariate analysis revealed that showing a low grade of atypical FDG uptake was the only independent risk factor of short-term recurrence, and none of the patients with recurrent disease had atypical FDG uptake that may reflect the activation of BAT. These results indicated that the presence of BAT is associated with HER2 expression and the absence of BAT may be a prognostic factor for breast cancer.
Multi-Antenna Interference Management for Coded Caching

A multi-antenna broadcast channel scenario is considered where a base station delivers contents to cache-enabled user terminals. A joint design of coded caching (CC) and multigroup multicast beamforming is proposed to benefit from spatial multiplexing gain, improved interference management and the global CC gain, simultaneously. The developed general content delivery strategies utilize the multiantenna multicasting opportunities provided by the CC technique while optimally balancing the detrimental impact of both noise and inter-stream interference from coded messages transmitted in parallel. Flexible resource allocation schemes for CC are introduced where the multicast beamformer design and the receiver complexity are controlled by varying the size of the subset of users served during a given time interval, and the overlap among the multicast messages transmitted in parallel, indicated by parameters <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$\beta $ </tex-math></inline-formula>, respectively. Degrees of freedom (DoF) analysis is provided showing that the DoF only depends on <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula> while it is independent of <inline-formula> <tex-math notation="LaTeX">$\beta $ </tex-math></inline-formula>. The proposed schemes are shown to provide the same degrees-of-freedom at high signal-to-noise ratio (SNR) as the state-of-art methods and, in general, to perform significantly better, especially in the finite SNR regime, than several baseline schemes.
nCREANN: Nonlinear Causal Relationship Estimation by Artificial Neural Network; Applied for Autism Connectivity Study

Quantifying causal (effective) interactions between different brain regions are very important in neuroscience research. Many conventional methods estimate effective connectivity based on linear models. However, using linear connectivity models may oversimplify the functions and dynamics of the brain. In this paper, we propose a causal relationship estimator called nonlinear Causal Relationship Estimation by Artificial Neural Network (nCREANN) that identifies both linear and nonlinear components of effective connectivity in the brain. Furthermore, it can distinguish between these two types of connectivity components by calculating the linear and nonlinear parts of the network input-output mapping. The nCREANN performance has been verified using synthesized data and then it has been applied on EEG data collected during rest in children with autism spectrum disorder (ASD) and typically developing (TD) children. The results show that overall linear connectivity in TD subjects is higher, while the nonlinear connectivity component is more dominant in ASDs. We suggest that our findings may represent different underlying neural activation dynamics in ASD and TD subjects. The results of nCREANN may provide new insight into the connectivity between the interactive brain regions.
Early Calcification of Renal Allografts Detected by Protocol Biopsies: Causes and Clinical Implications

Interstitial calcification has been described in renal allografts, however, the etiology and significance of this finding for the graft are unclear. The aim of this study was to examine calcification in serial protocol biopsies, to test the hypothesis that calcification is related to parameters of calcium homeostasis in these patients and to analyze a possible relation between calcification and graft function at 1 year. We studied 213 patients with 586 protocol biopsies obtained 6 weeks, 3 and 6 months after transplantation. Calcifications increased over time, from 6.1% at 6 weeks to 17.8% at 6 months. Out of the 213 patients, 56 had calcification in one or more biopsies. Patients age and gender, underlying renal disease, dialysis mode and duration, previous transplantations, donor type, age and gender, HLA matches and ischemia time had no influence on calcification. Calcification was not related to rejection episodes, acute tubular lesions, calcineurin inhibitor toxicity or tubulointerstitial fibrosis and tubular atrophy. Patients with calcification had significantly higher serum parathormone and calcium levels. In patients with calcification, high PTH levels correlated with an inferior outcome of graft function at 1 year after transplantation (p < 0.05). Therefore, treatment of hyperparathyroidism should be considered earlier and more often in these patients.