Miracle-dz/UniFAR-FTUs huggingface dataset:
Visual Face Perception of Adults with Unilateral Cleft Lip and Palate in Comparison to Controls—An Eye-Tracking Study

Objective To assess how faces with a cleft lip and palate are perceived and to study how faces with and without a unilateral cleft lip and palate are viewed by individuals with a unilateral cleft lip and/or palate in comparison to nonaffected controls. Design Prospective clinical study. Setting Department of Orthodontics and Department of Psychology, University of Wuerzburg. Participants Thirty-three participants (20 men and 13 women; mean age, 25.4 ± 6.6 years) with a unilateral cleft lip and/or palate and a control group of 30 participants (15 men and 15 women; mean age, 26.8 ± 3.4 years) were enrolled in this study. Main Outcome Measures Eye movements were analyzed via an eye-tracking camera while all participants looked at pictures of faces with and without a unilateral cleft lip and palate. Results The nose and the mouth area of pictures of faces with a unilateral cleft lip and palate were looked at significantly longer by both groups. Additionally, the participants with a unilateral cleft lip and/or palate looked at faces with and without a unilateral cleft lip and palate differently, taking more time to view the nose and less time to view the eyes compared with the participants without a cleft lip and palate. Conclusion When perceiving a face with a unilateral cleft lip and palate, the observer's gaze is distracted to the nose and mouth area. Moreover, participants with a unilateral cleft lip and/or palate themselves focused greater attention on those features that are anomalous on their own faces in comparison to participants without a cleft lip and palate. Specifically, this different scanpath is reflected in the cumulative duration of the eye movements as well as in the initial facial scan pattern.
Generalization and combination of Markowitz - Sharpe's theories and new efficient frontier algorithm

Sharpe's efficient frontier or “capital market line” which is based on Markowitz's nonlinear efficient frontier consists of all different combinations of risky assets and is based on several assumptions, which displays the preference of this frontier to Markowitz's mean-variance efficient frontier (Busser, 1977; Merton, 1972). Although, this theory is effective for investing companies which holds unlimited amount of resources and huge amount of funds, it does not have any application for individuals who do not tend to borrow or lend and are willing to invest in limited number of shares. The most underlying purpose of this article is to present a mathematical model and to demonstrate the methods of investment in limited number of shares in a way that the unsystematic risk which the market does not reward is minimized.
Endogenous Indexing and Monetary Policy Models

Models in which firms use rules of thumb or partial indexing in their price setting have become prominent in the recent monetary policy literature. The extent to which these firms adjust their prices to lagged inflation has been taken as fixed. We consider the implications of firms choosing the optimal degree of indexation so these simple pricing rules deliver prices as close as possible to those which would be chosen optimally. We find that the degree of indexation depends on the extent of persistence in the economy such that models with constant indexation are vulnerable to the Lucas critique. We also study the interactions between firms price setting and the macroeconomic environment finding that, for the models which appear most plausible on microeconomic grounds, the Nash equilibrium between firms and the policy maker is characterised by zero indexation and zero macroeconomic persistence.
XIAP therapy increases survival of transplanted rod precursors in a degenerating host retina.

PURPOSE To assess the survival of rod precursor cells transplanted into the Rd9 mouse, a model of X-linked retinal degeneration, and the effect of antiapoptotic therapy with X-linked inhibitor of apoptosis (XIAP) on preventing cell loss. METHODS Dissociated retinal cells from P4 Nrlp-GFP mice were transplanted into the subretinal space of 2-, 5-, and 8-month-old Rd9 mice. Histology, immunohistochemistry, and quantification of integrated cells were performed every month for up to 3 months after transplantation. XIAP delivery to donor cells was accomplished by transfection with adenoassociated virus (AAV-XIAP). Intraretinal activation of immune modulators was assessed using a quantitative real-time polymerase chain reaction-based immune response array. RESULTS GFP-positive rod precursors were able to integrate into the outer nuclear layer (ONL) of the Rd9 retina. Transplanted cells underwent morphologic differentiation with the formation of inner and outer segments and synaptic projections to bipolar cells. Integration of donor cells into the ONL increased as a function of host age at the time of transplantation. The number of integrated cells was maximal at 1 month after transplantation and then decreased with time. Survival of integrated cells was significantly increased when donor cells were pretreated with AAV-XIAP. We did not detect any donor cell-specific activation of inflammation within the host retina. CONCLUSIONS Survival of integrated cells decreases with time after transplantation but can be significantly increased with XIAP antiapoptotic therapy. Preventing programmed cell death through XIAP therapy may be an important component of future therapeutic retinal cell transplantation strategies.
Forecasting the Energy Consumption of China by the Grey Prediction Model

Abstract Energy consumption has important significance for every country in the world. To successfully predict the future energy consumption by a mathematical method is very important for relevant scientific study. In this article, China, the rising power of the world and one of the biggest energy consumption countries, is significantly taken as the research target for grey theory prediction. According to the actual energy consumption statistics of China from 1998 to 2006, this article established the grey model GM(1,1) for the total energy, coal energy and clean energy consumption of China, respectively, with a corresponding precision check-up thereafter. The results show the three prediction models are all in the first precision level, which is suitable for simulating and forecasting the original data sequences of the energy consumption characterized by grey type. By comparing the results of the three models, all three energy consumption types are in the trending upward, but clean energy consumption is especially getting the upper hand.
Predictors of Retention Among African American and Hispanic Older Adult Research Participants in the Well Elderly 2 Randomized Controlled Trial

The purpose of this study was to document predictors of long-term retention among minority participants in the Well Elderly 2 Study, a randomized controlled trial of a lifestyle intervention for community-dwelling older adults. The primary sample included 149 African American and 92 Hispanic men and women aged 60 to 95 years, recruited at senior activity centers and senior residences. Chi-square and logistic regression procedures were undertaken to examine study-based, psychosocial and health-related predictors of retention at 18 months following study entry. For both African Americans and Hispanics, intervention adherence was the strongest predictor. Retention was also related to high active coping and average (vs. high or low) levels of activity participation among African Americans and high social network strength among Hispanics. The results suggest that improved knowledge of the predictors of retention among minority elders can spawn new retention strategies that can be applied at individual, subgroup, and sample-wide levels.
Black-White Earnings Over the 1970s and 1980s: Gender Differences in Trends

This paper uses CPS data to analyze gender differences in black-white annual earnings trends over the 1970s and 1980s. We find that in at least two respects black women fared better than men over this period. First, due to decreasing relative annual time inputs for black males, but not black females, black women experienced increases in both annual earnings and estimated wages compared to white women, while black men gained only in terms of wages compared to white men. Second, since the gender earnings gap among whites was narrowing during this time, as black women's wages rose relative to white women's, they also made faster progress relative to white males than did black males. In other important respects, however, the experience of black men and women over the period was similar. First, for both groups, while earnings and wages relative to whites of the same sex rose during the 1970s, they stagnated or declined during the 1980s. Second, in contrast to the 1960s, younger blacks did not fare better than older blacks during the 1970s and 1980s. While in 1971, both unadjusted wage ratios and adjusted earnings ratios were highest within each sex group for labor market entrants, by 1988 these ratios were fairly similar across experience groups.
BESSEL PROCESSES, ASIAN OPTIONS, AND PERPETUITIES

Using Bessel processes, one can solve several open problems involving the integral of an exponential of Brownian motion. This point will be illustrated with three examples. The first one is a formula for the Laplace transform of an Asian option which is “out of the money. ”The second example concerns volatility misspecification in portfolio insurance strategies, when the stochastic volatility is represented by the Hull and White model. The third one is the valuation of perpetuities or annuities under stochastic interest rates within the Cox‐Ingersoll‐Ross framework. Moreover, without using time changes or Bessel processes, but only simple probabilistic methods, we obtain further results about Asian options: the computation of the moments of all orders of an arithmetic average of geometric Brownian motion; the property that, in contrast with most of what has been written so far, the Asian option may be more expensive than the standard option (e.g., options on currencies or oil spreads); and a simple, closed‐form expression of the Asian option price when the option is “in the money,” thereby illuminating the impact on the Asian option price of the revealed underlying asset price as time goes by. This formula has an interesting resemblance with the Black‐Scholes formula, even though the comparison cannot be carried too far.
ATAD2B is a phylogenetically conserved nuclear protein expressed during neuronal differentiation and tumorigenesis

ATAD2 is an E2F target gene that is highly expressed in gastrointestinal and breast carcinomas. Here we characterize a related gene product, ATAD2B. Both genes are evolutionarily conserved, with orthologues present in all eukaryotic genomes examined. Human ATAD2B shows a high degree of similarity to ATAD2. Both contain an AAA domain and a bromodomain with amino acid sequences sharing 97% and 74% identity, respectively. The expression of ATAD2B was studied in the chicken embryo using a polyclonal antibody raised against a recombinant fragment of human ATAD2B. Immunohistochemistry revealed transient nuclear expression in subpopulations of developing neurons. The transient nature of the expression was confirmed by immunoblotting homogenates of the developing telencephalon. Cell fractionation was used to confirm the nuclear localization of ATAD2B in the developing nervous system: anti‐ATAD2B recognizes a smaller band (approximately 160 kDa) in the nuclear fraction and a larger band (approximately 300 kDa) in the membrane fraction, suggesting that posttranslational processing of ATAD2B may regulate its transport to the nucleus. The expression of ATAD2B was also studied in human tumors. Oncomine and immunohistochemistry reveal ATAD2B expression in glioblastoma and oligodendroglioma; ATAD2B immunostaining was also elevated in human breast carcinoma. In tumors ATAD2B appears to be cytoplasmic or membrane bound, and not nuclear. Our observations suggest that ATAD2B may play a role in neuronal differentiation and tumor progression.
Application and Evaluation of Local and Global Analysis for Dynamic Models of Infectious Disease Spread

In this thesis, we applied local analysis tools (eigenvalue and eigenvalue elasticity analysis, global function elasticity/sensitivity analysis), and global analysis tools (deriving the location and stability of fixed points) to both aggregate and individuallevel dynamic models of infectious diseases. We sought to use these methods to gain insight into the models and to evaluate the use of these methods to study their short-term and long-term dynamics and the influences of parameters on the models. We found that eigenvalues are effective for understanding short-term behaviours of a nonlinear system, but less effective in providing insights of the long-term impacts of a parameter change on its behaviours. In term of disease control, local changes of behaviours, yielded from the changes of parameters based on eigenvalue elasticity, are able to alter behaviours in a short-term, especially in the period of a disease outbreak. While eigenvalue elasticity analysis can be helpful for understanding the impact of parameter changes for simple aggregate models, such analyses prove unwieldy and complicated, particularly for models with large number of state variables; and easily fall prey to eigenvalue multiplicity problems for large individual-based models, and distracting artifacts associated with small denominators. In response to these concerns, we introduced other local methods (global function elasticity/sensitivity analyses) that capture many of the advantages of eigenvalue elasticity methods with much greater simplicity. Unfortunately, parameter changes guided by these local analysis techniques are often insufficient to alter behaviours in the longer-term, such as when system behaviours approach stable endemic equilibria. By contrast, the global analytic tools, such as fixed point location and stability analysis, are effective for providing insights into the global behaviours of disease spread in the long-term, as well as their dependence on parameters. Using all of the above analysis as a toolset, we gained some possible insights into combination of local and global approaches. Choice of applying local or global analysis tools to infectious disease models is dependent on the specific target of policy makers as well as model type.
Fire and Fuel Management Communication Strategies: Citizen Evaluations of Agency Outreach Activities

ABSTRACT Wildfire impacts have increased in recent years. In response, public agencies have undertaken measures to reduce forest fuels and improve forest health conditions. To be successful these programs require a supportive local constituency. Research has identified a relationship between public understanding of, and support for, fuel and fire management activities. Correspondingly, in many areas federal agencies have focused their communication strategies on fuel management programs. This article draws on research in adult learning to develop a framework to evaluate citizen reactions to 11 different outreach programs at study locations in Arizona, Colorado, Oregon, and Utah. Few differences in citizen reactions were found among study locations, but results suggest interactive formats were more effective than unidirectional methods and are also more consistent with principles of adult learning. However, people were less likely to have participated in interactive activities. Contributions of learning theory principles and the efficacy of individual formats are discussed.
Belief-Based Storage Systems

Motivation: The current data growth and consequent increase in complexity of its usage patterns indicate that intelligent management of data storage is becoming ever more crucial [7, 20, 23]. We rely on the claim that efficient pattern discovery and description, coupled with the observed predictability of complex patterns within many high-performance applications, offers significant potential to enable many I/O optimizations [11]. We developed a compact flexible caching and pre-fetching framework [17] that could, potentially address any imposed reliability, performance, energy efficiency requirement and have the ability to add any relevant information. Here, we discuss possible ways to extend this framework towards belief based storage systems.
A White Spruce Gene Catalog for Conifer Genome Analyses1[W][OA]

Several angiosperm plant genomes, including Arabidopsis (Arabidopsis thaliana), rice (Oryza sativa), poplar (Populus trichocarpa), and grapevine (Vitis vinifera), have been sequenced, but the lack of reference genomes in gymnosperm phyla reduces our understanding of plant evolution and restricts the potential impacts of genomics research. A gene catalog was developed for the conifer tree Picea glauca (white spruce) through large-scale expressed sequence tag sequencing and full-length cDNA sequencing to facilitate genome characterizations, comparative genomics, and gene mapping. The resource incorporates new and publicly available sequences into 27,720 cDNA clusters, 23,589 of which are represented by full-length insert cDNAs. Expressed sequence tags, mate-pair cDNA clone analysis, and custom sequencing were integrated through an iterative process to improve the accuracy of clustering outcomes. The entire catalog spans 30 Mb of unique transcribed sequence. We estimated that the P. glauca nuclear genome contains up to 32,520 transcribed genes owing to incomplete, partially sequenced, and unsampled transcripts and that its transcriptome could span up to 47 Mb. These estimates are in the same range as the Arabidopsis and rice transcriptomes. Next-generation methods confirmed and enhanced the catalog by providing deeper coverage for rare transcripts, by extending many incomplete clusters, and by augmenting the overall transcriptome coverage to 38 Mb of unique sequence. Genomic sample sequencing at 8.5% of the 19.8-Gb P. glauca genome identified 1,495 clusters representing highly repeated sequences among the cDNA clusters. With a conifer transcriptome in full view, functional and protein domain annotations clearly highlighted the divergences between conifers and angiosperms, likely reflecting their respective evolutionary paths.
Portfolio optimization with non-constant volatility and partial information

We consider a stock market model where prices satisfy a stochastic differential equation. The instantaneous rates of return are modeled as a continuous time Markov chain with finitely many states. For the volatility we consider the Hobson-Rogers model and one of its modifications. On one hand these allow to work within a complete market, on the other hand they are well motivated since they can account for realistic volatility smiles. The investor's objective is to maximize the expected utility of the terminal wealth under partial information; the latter meaning that investment decisions are based on the knowledge of the stock prices only. We derive an explicit representation of the optimal trading strategy using Malliavin calculus and estimate the model parameters using Markov chain Monte Carlo methods. We apply the theoretical results to simulated and market data.
Indoor exposures and recurrent wheezing in infants: a study in the BAMSE cohort

Aim: The aim of this study was to examine the relationship between indoor exposures and the home environment, and the development of recurrent wheezing during infancy. Methods: A birth cohort, comprising 4089 children, was followed. Information on exposures was obtained shortly after birth, and episodes of wheezing were recorded when the infants were 1 and 2 y of age. In a nested case‐control study, 181 infants were enrolled, who had three or more reported episodes of wheezing after 3 mo of age combined with either use of inhaled steroids or symptoms of bronchial hyper‐reactivity, and 359 age‐matched controls. Home inspections were performed during the winter following enrolment, and indoor conditions were measured. Results: Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated. The OR for recurrent infant wheezing associated with signs of dampness reported prospectively by parents was 1.4 (0.9–2.2), and the OR for observed signs of dampness at home inspections was 1.6 (1.0–2.5). A trend was found in the risk of recurrent wheezing in relation to the number of indicators of dampness: OR 1.3 (0.8–2.2) for one sign of dampness and OR 2.7 (1.3–5.4) for three or more signs of dampness. Newly painted surfaces in the child's bedroom was associated with an increased OR for recurrent wheezing: 1.7 (1.3–2.6).
Waste recovery using packaging waste recovery notes: a cost-effective way of meeting targets?

To comply with EU recycling targets for packaging waste, the UK relies on an industry run and market based eco-tax levied by reprocessors on obligated businesses. After examining the details of this approach, the use of Packaging Waste Recovery Notes is assessed in terms of its allocative impact and the contribution made to eco-efficiency. The evidence indicates the UK system has minimized the cost of delivering current EU targets, but has not been able to deliver allocative efficiency or to demonstrate dynamic improvements in resource use. Its effectiveness in meeting impending higher targets remains open to question.
Role of farm real estate in a globally diversified asset portfolio

Purpose - This paper seeks to examine the benefits of further diversifying a global portfolio of financial assets with New Zealand farm real estate (FRE). Design/methodology/approach - The paper compares efficient sets generated with and without FRE using portfolio theory. Findings - The results show that given the predominantly negative correlation between FRE and financial assets, the risk-return tradeoffs of portfolios of financial assets can be improved significantly. The diversification benefits measured in terms of risk reduction, return enhancement, and improvement in the Sharpe performance ratios are robust under a number of FRE risk-return scenarios as well as under high and low inflationary periods. Using five and ten-year rolling periods it also finds that FRE is a consistent part of risk efficient portfolios. Consistent with the results reported in Lee and Stevenson, for the UK real estate the risk reduction benefits of diversifying with FRE are larger than the risk enhancement benefits. Practical implications - The results suggest that FRE takes on a consistent role of risk-reducer rather than a return-enhancer in a globally diversified portfolio. FRE appears to deserve more serious consideration by investment practitioners that it has been accorded in the past. Originality/value - The study examines the role of direct real estate in a globally diversified portfolio of financial assets.
The Value Premium and the CAPM

We examine (1) how value premiums vary with firm size, (2) whether the CAPM explains value premiums, and (3) whether, in general, average returns compensate β in the way predicted by the CAPM. Loughran's (1997) evidence for a weak value premium among large firms is special to 1963 to 1995, U.S. stocks, and the book‐to‐market value‐growth indicator. Ang and Chen's (2005) evidence that the CAPM can explain U.S. value premiums is special to 1926 to 1963. The CAPM's more general problem is that variation in β unrelated to size and the value‐growth characteristic goes unrewarded throughout 1926 to 2004.