Miracle-dz/UniFAR-FTUs huggingface dataset:
JIVE: Java Interactive Software Visualization Environment

JIVE (Java interactive software visualization environment) is a system for the visualization of Java coded algorithms and data structures. It supports the rapid development of interactive animations through the adoption of an object oriented approach. JIVE introduces several significant innovations such as a distributed architecture able to separate transparently the visualization activity from the underlying communication needed to support it. Therefore, it becomes possible to use JIVE in a variety of scenarios ranging from debugging algorithms to software visualization in virtual classrooms environments. Moreover, JIVE uses a zoomable user interface for representing algorithms: seamless visualization of both small and large data sets is achieved by using semantic zooming. Finally, JIVE comes with a collection of already animated data types including data structures provided by the Java standard library
A new model for persian multi-part words edition based on statistical machine translation

Multi-part words in English language are hyphenated and hyphen is used to separate different parts. Persian language consists of multi-part words as well. Based on Persian morphology, half-space character is needed to separate parts of multi-part words where in many cases people incorrectly use space character instead of half-space character. This common incorrectly use of space leads to some serious issues in Persian text processing and text readability. In order to cope with the issues, this work proposes a new model to correct spacing in multi-part words. The proposed method is based on statistical machine translation paradigm. In machine translation paradigm, text in source language is translated into a text in destination language on the basis of statistical models whose parameters are derived from the analysis of bilingual text corpora. The proposed method uses statistical machine translation techniques considering unedited multi-part words as a source language and the space-edited multi-part words as a destination language. The results show that the proposed method can edit and improve spacing correction process of Persian multi-part words with a statistically significant accuracy rate.
Beyond Janov: the Healing Touch

sought psychological asylum from contemporary America by writing a PhD for the University of London on Carl Rogers’ theory of personality growth While in private practice in London, he learned the art of body psychotherapy from Ola Raknes of Oslo, and Simeon Tropp and Alexander Lowen of New York Malcolm was in private practice in the San Francisco Bay Area until 1975 when he returned to Europe He plans to reside there indefinitely writing and training other professionals in humanistic body psychotherapy
Mind-Body Therapies in Individuals With Dementia: An Integrative Review.

Mind-body therapies frequently derive from Eastern philosophies and are becoming increasingly popular. These therapies, such as meditation, yoga, tai chi, qigong, biofield therapies, and guided imagery, have many reported benefits for improving symptoms and physiological measures associated with various chronic diseases. However, clinical research data concerning the effectiveness of these practices in individuals with dementia have not been evaluated using a synthesis approach. Thus, an integrative review was conducted to evaluate studies examining the efficacy of mind-body therapies as supportive care modalities for management of symptoms experienced by individuals with dementia. Findings from the studies reviewed support the clinical efficacy of mind-body practices in improving behavioral and psychological symptoms exhibited by individuals with dementia. [Res Gerontol Nurs. 2017; 10(6):288-296. ].
Ameliorating Patient-Caregiver Stigma in Early-Stage Parkinson's Disease using Robot co-Mediators

Facial masking in early stage Parkinson’s disease leads to a well-documented deterioration (stigmatization) in the patient-caregiver relationship. This research described in this paper is concerned with preserving dignity in that bond where otherwise it might be lost, through the use of a robot co-mediator that will be capable of monitoring the human-human relationship for lack of congruence in the perceived emotional states of the parties concerned. This paper describes the component architectural modules that are being used in support of this 5year effort, including an ethical architecture developed earlier for the military and previous research on affective companion robots for Sony and Samsung that are able to express affective state through kinesics and proxemics.
The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages

CD3γ and CD3δ are the most closely related CD3 components, both of which participate in the TCRαβ–CD3 complex expressed on mature T cells. Interestingly, however, CD3δ does not appear to participate functionally in the pre‐T‐cell receptor (TCR) complex that is expressed on immature T cells: disruption of CD3δ gene expression has no effect on the developmental steps controlled by the pre‐TCR. Here we report that in contrast with CD3δ, CD3γ is an essential component of the pre‐TCR. We generated mice selectively lacking expression of CD3γ, in which expression of CD3δ, CD3ϵ, CD3ζ, pTα and TCRβ remained undisturbed. Thus, all components for composing a pre‐TCR are available, with the exception of CD3γ. Nevertheless, T‐cell development is severely inhibited in CD3γ‐deficient mice. The number of cells in the thymus is reduced to <1% of that in normal mice, and the large majority of thymocytes lack CD4 and CD8 and are arrested at the CD44−CD25+ double negative (DN) stage of development. Peripheral lymphoid organs are also practically devoid of T cells, with absolute numbers of peripheral T cells reduced to only 2–5% of those in normal mice. Both TCRαβ and TCRγδ lineages fail to develop effectively in CD3γ‐deficient mice, although absence of CD3γ has no effect on gene rearrangements of the TCRβ, δ and γ loci. Furthermore, absence of CD3γ results in a severe reduction in the level of TCR and CD3ϵ expression at the cell surface of thymocytes and peripheral T cells. The defect in the DN to double positive transition in mice lacking CD3γ can be overcome by anti‐CD3ϵ‐mediated cross‐linking. CD3γ is thus essential for pre‐TCR function.
Steward: Scaling Byzantine Fault-Tolerant Systems to Wide Area Networks

This paper presents the first hierarchical Byzantine tolerant replication architecture suitable to systems that span multiple wide area sites. The architecture confines the effects of any malicious replica to its local site, reduces message complexity of wide area communication, and allows read-only queries to be performed locally within a site for the price of additional hardware. A prototype implementation is evaluated over several network topologies and is compared with a flat Byzantine tolerant approach.
Bcl-xL Silencing Induces Alterations in hsa-miR-608 Expression and Subsequent Cell Death in A549 and SK-LU1 Human Lung Adenocarcinoma Cells

Bcl-xL is an anti-apoptotic protein that is frequently found to be overexpressed in non-small cell lung cancer leading to an inhibition of apoptosis and poor prognosis. Recently, the role of miRNAs in regulating apoptosis and cell survival during tumorigenesis has become evident, with cancer cells showing perturbed expression of various miRNAs. In this study, we utilized miRNA microarrays to determine if miRNA dysregulation in bcl-xL silenced lung adenocarcinoma cells could be involved in regulating cell death. Short interfering RNA-based transfection of A549 and SK-LU1 lung adenocarcinoma cells was successful in inducing a reduction in bcl-xL expression levels, resulting in a decrease in cell viability. A total of 10 miRNAs were found to be significantly differentially expressed when compared between siRNA-transfected and non-transfected cells including hsa-miR-181a, hsa-miR-769-5p, hsa-miR-361-5p, hsa-miR-1304 and hsa-miR-608. When overexpression studies on hsa-miR-608 was performed via transfection of miRNA mimics, cell death was found to be induced in A549 and SK-LU1 cells in comparison to untreated cells. This effect was reversed when knockdown studies involving anti-sense inhibitors were introduced. Combination of siRNA based silencing of bcl-xL (siBcl-xL) followed by anti-sense inhibitor transfection led to a decrease in the apoptotic population of A549 and SK-LU1 cells in comparison to cells only treated with siBcl-xL, illustrating the connection between bcl-xL, hsa-miR-608 and cell death. Gene target prediction analysis implicated the PI3K/AKT, WNT, TGF-β, and ERK signaling pathways as targets of bcl-xL induced miRNA alterations. We have demonstrated that bcl-xL silencing in A549 and SK-LU1 cells leads to the occurrence of cell death through the dysregulation of specific miRNAs. This study also provides a platform for anti-sense gene therapy whereby miRNA expression can be exploited to increase the apoptotic properties in lung adenocarcinoma cells.
A hierarchical extension of manipulation primitives and its integration into a robot control architecture

Manipulation Primitives are state-of-the-art for describing and performing complex manipulation tasks - especially in industrial applications. They combine easy task specification and execution which are key components for the success of this paradigm. However, there are some flaws when describing a complex task by decomposing it into Manipulation Primitives. For instance, the relations between the individual Manipulation Primitives cannot be captured by the original definition but have to be defined in additional glue code. This contribution introduces an extended definition of Manipulation Primitives to describe manipulation tasks as hierarchical structures using Manipulation Primitives at each level of the hierarchy. Additionally, a concept for a generic control architecture is presented which is capable of meeting the requirements of the extended Manipulation Primitive concept and which can be easily plugged“ together using modular code blocks. ”
Emotional development and emotional intelligence: Educational implications.

General Principles * What Is Emotional Intelligence? John D. Mayer and Peter Salovey * Educators Commentary Karol DeFalco * Emotional Competence and Self-Regulation in Childhood Carolyn Saarni * Educators Commentary Marianne Novak Houston * Friends, Diplomats, and Leaders in Kindergarten: Interpersonal Intelligence in Play Thomas Hatch * Educators Commentary Linda Lantieri * Brain Development and Emotional Development: The Role of Teaching in Organizing the Frontal Lobe Mark T. Greenberg and Jennie L. Snell * Educators Commentary Jo-An Vargo Social And Economic Competencies * Emotional Responding: Regulation, Social Correlates, and Socialization Nancy Eisenberg, Richard A. Fabes, and Sandra Losoya * Educators Commentary Rebecca Nellum-Williams * Emotion Regulation During Childhood: Developmental, Interpersonal, and Individual Considerations Eliot M. Brenner and Peter Salovey * Educators Commentary Patricia Moore Harbour and Jill Stewart * Promoting Childrens Social-Emotional Adjustment with Peers Stephen R. Asher and Amanda J. Rose * Educators Commentary Robert (Chip) Wood Applications * The Questions of Development in Emotion Jeannette Haviland-Jones, Janet L. Gebelt, and Janice C. Stapley * Educators Commentary Marrianne Novak Houston * Linking Research and Educational Programming to Promote Social and Emotional Learning Joseph E. Zins, Lawrence F. Travis III, and Penny A. Freppon * Educators Commentary Mickey Kavanagh
Simple peak-to-average power ratio reduction by non-regular signal constellation sets

Peak-to-average power ratio (PAPR) is a major problem for high rate communication systems, which employ e.g. quadrature amplitude modulation (QAM) with a large signal constellation set (SCS). We propose a novel and extremely simple scheme for PAPR reduction, which removes the critical channel symbols from the SCS and instead map the respective bit patterns to other existing channels symbols. This results in non-unique bit mappings for non-regular SCSs. We demonstrate the PAPR reduction by examples which achieve reductions of close to 45% with almost no impact on the performance, which is proven by simulations. The performance is further analyzed and explained using a mutual information analysis.
The Relationships Between MBO System Strength and Goal‐Climate Quality and Strength

We adopted Bowen and Ostroff's (2004) HRM system strength concept so as to test it within the context of a management by objectives (MBO) system, which was utilized by six independent firms owned by a large, diversified family business group in Turkey. For this purpose, we surveyed the middle managers to measure 10 context-specific metafeatures of the MBO system. By using aggregated scores at the functional group level (N = 47), we captured the distinctiveness, consistency, and consensus dimensions of this HRM practice. We tested and compared three alternative theoretical models of HRM strength where the three dimensions have compensatory, additive, and distinctiveness mediated effects on climate quality and strength. Results support the compensatory model and indicate that the strength of the MBO system (as a reflective latent variable representing the shared variance of the system's distinctiveness, consistency, and consensus) is positively related to business units� quality and strength of goal climate. In addition, distinctiveness�but not consistency and consensus�of the MBO system appears to be particularly critical for the emergence of a strong and high-quality goal climate. Lastly, implications and limitations of the study as well as possible future research directions are discussed. © 2014 Wiley Periodicals, Inc.
A structural transition in d(AT)n.d(AT)n inserts within superhelical DNA.

We have constructed plasmids carrying d(AT)n.d(AT)n inserts of different lengths. Two-dimensional gel electrophoresis patterns show that an increase in the negative superhelicity of these DNAs brings about a structural transition within the inserts, resulting in a reduction of the superhelical stress. However, this reduction corresponds to the expected values neither for cruciform nor the Z form. Those DNA topoisomers in which the structural transition had occurred proved to be specifically recognizable by single-strand-specific endonuclease S1, with the cleavage site situated at the centre of the insert. These data, as well as kinetic studies, suggest that the cloned d(AT)n.d(AT)n sequences adopt a cruciform rather than the Z-form structure. We discuss plausible reasons of the discrepancy between the observed superhelical stress release and that expected for the transition of the insert to the cruciform state.
Feminists and psychological practice

Part 1 Choosing psychology: "where's your sense of humour? " - swimming against the tide in higher education, Carolyn Kagan and Sue Lewis moving out of psychology - two accounts, Sue Sharpe and Jane Jefferson choosing psychology or not throwing the baby out with the bathwater, Jane Ussher making a difference - questioning women's studies, Meg Coulson and Kum-Kum Bhavnai. Part 2 Changing definitions of psychological knowledge: feminism as antipsychology - learning and teaching in feminist psychology, Corinne Squire social research in the context of feminist psychology, Ann Phoenix fantasy or reality? the problem with psychoanalytic interpretation in psychotherapy with women, Maye Taylor resisting the discipline, Celia Kitzinger. Part 3 Struggles and change: women organizing within psychology - two accounts, Sue Wilkinson and Jan Burns steps towards silence - women in educational psychology, Anonymous at whose service? a herstory of educational psychology, Anonymous women in the shadows - women, clinical psychology and feminism, Christine Adcock and Karen Newbigging.
A System Dynamics Approach to Study Virtual Communities

In recent years, extensive studies of many interesting aspects of virtual community dynamics promoted a better understanding of this area. One of the most challenging problems facing builders of virtual communities is the design of incentive mechanisms that can ensure user participation. However, running virtual community experiments in the real world is expensive, and requires a great deal of motivation from users. In this paper we advocate a system dynamics approach to simulate the overall behaviors of participants in the communities, which can provide insights into the user motivation process, incentive mechanism evaluation and community development. A simulation model for a virtual community called Comtella is presented, and the results are very promising
Using Test Data in Clinical Practice: A Handbook for Mental Health Professionals

Preface Introduction to Testing in Clinical Practice The WAIS-III: Guidelines for Administration and Interpretation Presentation of WAIS-III Findings in Reports and to Clients The MMPI-2 and MMPI-A: Guidelines for Administration and Interpretation Effective MMPI Feedback Sessions and Written Reports The Strong Interest Inventory and the Kuder Career Search Interest Inventory Interpretation Adult Case Study Ethical and Legal Responsibilities in Testing in Clinical Situations Appendix A: MMPI-2 Practice Case of Jerome
Functional observer based higher order sliding mode control for DC-DC Buck converter

The study in this article focuses on the design of functional observer based higher order sliding mode controller for DC-DC Buck Convertor. Functional Observer is used for linear estimation of unmeasurable state variables which are required for the closed loop stability of a dynamic system without unnecessarily estimating all the individual states. The proposed method thus reduces the overall complexity, cost of the system and minimizes the number of individual sensors which are required to measure each state variable of the system. Functional Observer based higher order sliding mode controller is used to obtain chattering free control signal which assures easy practical implementation of the controller when compared to the functional observer based conventional sliding mode controller. The robustness of the proposed observer based controller is tested under input parameter variation and unknown input disturbance.
Fossils and living taxa agree on patterns of body mass evolution: a case study with Afrotheria

Most of life is extinct, so incorporating some fossil evidence into analyses of macroevolution is typically seen as necessary to understand the diversification of life and patterns of morphological evolution. Here we test the effects of inclusion of fossils in a study of the body size evolution of afrotherian mammals, a clade that includes the elephants, sea cows and elephant shrews. We find that the inclusion of fossil tips has little impact on analyses of body mass evolution; from a small ancestral size (approx. 100 g), there is a shift in rate and an increase in mass leading to the larger-bodied Paenungulata and Tubulidentata, regardless of whether fossils are included or excluded from analyses. For Afrotheria, the inclusion of fossils and morphological character data affect phylogenetic topology, but these differences have little impact upon patterns of body mass evolution and these body mass evolutionary patterns are consistent with the fossil record. The largest differences between our analyses result from the evolutionary model, not the addition of fossils. For some clades, extant-only analyses may be reliable to reconstruct body mass evolution, but the addition of fossils and careful model selection is likely to increase confidence and accuracy of reconstructed macroevolutionary patterns.
Serotyping of Streptococcus pneumoniae Isolates from Nasopharyngeal Samples: Use of an Algorithm Combining Microbiologic, Serologic, and Sequential Multiplex PCR Techniques

ABSTRACT We evaluated nasopharyngeal carriage of Streptococcus pneumoniae (pneumococci) in nine Alaskan communities and used an algorithm combining microbiologic, serologic, and sequential multiplex PCR (MP-PCR) techniques to serotype the isolates. After microbiological identification as pneumococci, isolates (n = 1,135) were serotyped using latex agglutination and Quellung tests (LA/Q) as well as a series of six sequential MP-PCR assays. Results from the two methods agreed for 94% (1,064/1,135) of samples. Eighty-six percent (61/71) of the discordant results were resolved. Discordant results occurred because (i) the MP-PCR gel was misread (31/61 [51%]), (ii) the LA/Q agglutination was misinterpreted (13/61 [21%]), (iii) two serotypes or sets of serotypes were identified by MP-PCR and only one of the two was identified by LA/Q (9/61 [15%]), (iv) different serotypes or sets of serotypes were identified by LA/Q and MP-PCR and both were correct (7/61 [11%]), and (v) the capsular polysaccharide locus (cps) did not amplify during the initial MP-PCR but was present upon retesting (1/61 [2%]). Overall, isolation of pneumococci followed by MP-PCR quickly and accurately identified pneumococcal serotypes in >97% of samples and made available isolates for additional tests such as antimicrobial susceptibility. Misinterpretation of the MP-PCR gel was identified as the main source of discordance. Increasing the number of MP-PCRs from six to seven and reducing the number of serotypes in each reaction may reduce this error. This method may be of use to laboratories characterizing large numbers of S. pneumoniae samples, especially when antimicrobial susceptibility data are needed.
TGFβ3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development

Epithelial mesenchymal transformation (EMT) of the medial edge epithelial (MEE) seam creates palatal confluence. This work aims to elucidate the molecular mechanisms by which TGFβ3 brings about palatal seam EMT. We collected mRNA for PCR analysis from individual transforming MEE cells by laser microdissection techniques and demonstrated that TGFβ3 stimulates lymphoid-enhancing factor 1 (LEF1) mRNA synthesis in MEE cells. We show with antisense β-catenin oligonucleotides that up-regulated LEF1 is not activated by β-catenin in palate EMT. We ruled out other TGFβ3 targets, such as RhoA and MEK1/2 pathways, and we present evidence using dominant-negative Smad4 and dominant-negative LEF1 showing that TGFβ3 uses Smads both to up-regulate synthesis of LEF1 and to activate LEF1 transcription during induction of palatal EMT. When phospho-Smad2 and Smad4 are present in the nucleus, LEF1 is activated without β-catenin. Our paper is the first to show that the Smad2,4/LEF1 complex replaces β-catenin/LEF1 during activation of EMT in vivo by TGFβ3.
Evidence-Based Practice: A Critical Appraisal

List of Contributors. 1 Introduction: The Context of Evidence--Based Practice. (Liz Trinder). 2 The Anatomy of Evidence--Based Practice: Principles and Methods. (Shirley Reynolds). 3 Evidence--Based Practice in General Practice and primary care. (Toby Lipman). 4 Evidence--Based Practice in Mental Health. (John Geddes). 5 Evidence--Based Public Health. (J.A. Muir Gray). 6 Evidence--Based Nursing Practice. (Richard Blomfield and Sally Harding). 7 Evidence--Based Practice in Social Work and Probation. (Liz Trinder). 8 Evidence--Based Practice in Education and the Contribution of Educational Research. (Martyn Hammersley). 9 Evidence--Based Human Resource Management. (Rob Briner). 10 A Critical Appraisal of Evidence--Based Practice. (Liz Trinder). Index.
Lipid interactions during virus entry and infection

For entry and infection viruses have developed numerous strategies to subjugate indispensable cellular factors and functions. Host cell lipids and cellular lipid synthesis machinery are no exception. Not only do viruses exploit existing lipid signalling and modifications for virus entry and trafficking, they also reprogram lipid synthesis, metabolism, and compartmentalization for assembly and egress. Here we review these various concepts and highlight recent progress in understanding viral interactions with host cell lipids during entry and assembly.