Miracle-dz/UniFAR-FTUs huggingface dataset:
Affordable LTE network benchmarking based on transport fleets

To gain competitive advantage in today's mobile market, cellular network testing, monitoring and improving customer experience is crucial. Today independent benchmarking companies are hired by mobile operators to run drive tests in a certain geographical areas. The high cost for running these tests results in a low frequency of execution, typically this benchmarking is executed no more than two or three times per year, which is not sufficient to follow the dynamics of an LTE network in a dense urban area. The majority of the drive testing costs come from the car, driver, and the in-car technician. Another approach is to take advantage of existing transportation companies to carry on network benchmarking services to Mobile Network Operators. Unattended measurement nodes can be deployed in existing transportation fleets without the need for dedicated field personnel, reducing the cost of testing up to 70%. This demo uses nodes placed in buses, available in several cities in Europe, to create and validate an automatic LTE network benchmark. The tool allows an easy comparative analyses of mobile network quality of Service and quality of experience parameters based on the operators raw data.
A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric Aβ, and Frank Neuronal Loss

Alzheimer's disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and widespread cortical neuronal loss (Selkoe, 2001). The “amyloid cascade hypothesis” posits that cerebral amyloid sets neurotoxic events into motion that precipitate Alzheimer dementia (Hardy and Allsop, 1991). Yet, faithful recapitulation of all AD features in widely used transgenic (Tg) mice engineered to overproduce Aβ peptides has been elusive. We have developed a Tg rat model (line TgF344-AD) expressing mutant human amyloid precursor protein (APPsw) and presenilin 1 (PS1ΔE9) genes, each independent causes of early-onset familial AD. TgF344-AD rats manifest age-dependent cerebral amyloidosis that precedes tauopathy, gliosis, apoptotic loss of neurons in the cerebral cortex and hippocampus, and cognitive disturbance. These results demonstrate progressive neurodegeneration of the Alzheimer type in these animals. The TgF344-AD rat fills a critical need for a next-generation animal model to enable basic and translational AD research.
Comparison between CHADS2 and CHA2DS2‐VASc score in a stroke cohort with atrial fibrillation

In patients with atrial fibrillation (AF), stroke risk stratification schemes have been developed to optimize antithrombotic treatment. The CHADS2 score is frequently used but has limitations. The CHA2DS2‐VASc score improves risk prediction. Our objectives are to describe CHADS2 and CHA2DS2‐VASc score distribution in a cohort of patients with AF and first‐ever ischaemic stroke (FIS) and to identify differences in embolic risk stratification.
Research of DPRP routing protocols in the precision-attack efficiency evaluation system

According to the particular demand of precision attack effectiveness evaluation (PAEE) system for the protocol of wireless sensor networks and on the base of the studying of robustness properties of wireless sensor networks and flooding protocol, we designed a double parents and reliable protocol (DPRP). This protocol defined level value and parent node, and limited spread scope of the data message in the broadcast networks by using the node's level and its own ID number. Thereby, it reduced energy consumption of network routing and improved real-time property and reliability of data transmission.
Social Saliency of the Cue Slows Attention Shifts

Eye gaze is a powerful cue that indicates where another person’s attention is directed in the environment. Seeing another person’s eye gaze shift spontaneously and reflexively elicits a shift of one’s own attention to the same region in space. Here, we investigated whether reallocation of attention in the direction of eye gaze is modulated by personal familiarity with faces. On the one hand, the eye gaze of a close friend should be more effective in redirecting our attention as compared to the eye gaze of a stranger. On the other hand, the social relevance of a familiar face might itself hold attention and, thereby, slow lateral shifts of attention. To distinguish between these possibilities, we measured the efficacy of the eye gaze of personally familiar and unfamiliar faces as directional attention cues using adapted versions of the Posner paradigm with saccadic and manual responses. We found that attention shifts were slower when elicited by a perceived change in the eye gaze of a familiar individual as compared to attention shifts elicited by unfamiliar faces at short latencies (100 ms). We also measured simple detection of change in direction of gaze in personally familiar and unfamiliar faces to test whether slower attention shifts were due to slower detection. Participants detected changes in eye gaze faster for familiar faces than for unfamiliar faces. Our results suggest that personally familiar faces briefly hold attention due to their social relevance, thereby slowing shifts of attention, even though the direction of eye movements are detected faster in familiar faces.
Prevalence of pathological internet use among adolescents in Europe: demographic and social factors.

AIMS To investigate the prevalence of pathological internet use (PIU) and maladaptive internet use (MIU) among adolescents in 11 European countries in relation to demographic, social factors and internet accessibility. DESIGN Cross-sectional survey. SETTING The 7th Framework European Union (EU) funded project, Saving and Empowering Young Lives in Europe (SEYLE), is a randomized controlled trial (RCT) evaluating interventions for risk behaviours among adolescents in Austria, Estonia, France, Germany, Hungary, Ireland, Israel, Italy, Romania, Slovenia and Spain, with Sweden serving as the coordinating centre. PARTICIPANTS A total of 11 956 adolescents (female/male: 6731/5225; mean age: 14.9 ± 0.89) recruited from randomly selected schools within the 11 study sites. MEASUREMENTS Internet users were classified by gender into three categories: adaptive, maladaptive and pathological, based on their score in the Young Diagnostic Questionnaire for Internet Addiction (YDQ). FINDINGS The overall prevalence of PIU was 4.4%; it was higher among males than females (5.2% versus 3.8%) and differed between countries (χ(2) = 309.98; d.f. = 20; P < 0.001). PIU correlated significantly with mean hours online and male gender. The highest-ranked online activities were watching videos, frequenting chatrooms and social networking; significantly higher rates of playing single-user games were found in males and social networking in females. Living in metropolitan areas was associated with PIU. Students not living with a biological parent, low parental involvement and parental unemployment showed the highest relative risks of both MIU and PIU. CONCLUSIONS Across a range of countries in Europe, using the Young Diagnostic Questionnaire for Internet Addiction yields a prevalence of 'pathological internet use' of 4.4% among adolescents, but varies by country and gender; adolescents lacking emotional and psychological support are at highest risk.
Intra Nasal In situ Gelling System of Lamotrigine Using Ion Activated Mucoadhesive Polymer

Background: A novel drug delivery system for treating acute epileptic condition. Objective: To develop an intranasal mucoadhesive formulation of Lamotrigine (LTG) loaded insitu gel, for the treatment of epilepsy to avoid possible side effects and first pass metabolism associated with conventional treatment. Methods: Lamotrigine was loaded into different polymeric solutions of gellan and xanthan gum. Results: All formulations subjected to various evaluation studies were within their acceptable limits. The pH of formulation ranges between 5.8 ±. 001 to 6.8 ±. 005 indicating that no mucosal irritation is expected as pH was in acceptable range. Invitro drug release from the mucoadhesive insitu gel formulations showed immediate drug release pattern with a maximum drug release of 97.02 ±0.54% for optimized G5 formulation within 20min. Exvivo permeation studies of optimized formulation G5 and control formulation was estimated. Exvivo permeation studies of G5 insitu formulation done for a period of 12 h resulted in slow, sustained release and greater permeability significance(P <0.05) through nasal mucosa when compared to control. Histopathological studies showed that G5 formulation was safer for nasal administration without any irritation. The stability studies indicated that gels were stable over 45 days in refrigerated condition (4±2ºC). Conclusion: The intranasal insitu gelling system is a promising novel drug delivery system for an antiepileptic drug lamotrigine which could enhance nasal residence time with increased viscosity and mucoadhesive character and provided better release profile of drug for treating acute epileptic conditions.
Multivariable Control of Single-Inductor Dual-Output Buck Converters

Cross regulation is the main technical challenge of a single-inductor multiple-output (SIMO) dc-dc converter. This paper proposes a multivariable digital controller to suppress the cross regulation of a single-inductor dual-output (SIDO) buck converter in continuous conduction mode (CCM) operation. The controller design methodology originates from the open-loop shaping of the multi-input multi-output (MIMO) systems. The control design procedure includes: 1) determination of a family of nonparametric models of the SIDO converter at operating points of interest, 2) determination of the class of the controller, and 3) system open-loop shaping by the convex minimization of the summation of the square second norm of the errors between the system open-loop transfer function matrices and a desired open-loop transfer function matrix. The proposed controller minimizes the coupling between the outputs of the SIDO converter and provides satisfactory dynamic performance in CCM operation. This paper describes the theoretical aspects involved in the design procedure of the controller and evaluates the performance of the controller based on simulation studies and experiments.
Products as Agents: Metaphors for Designing the Products of the IoT Age

Design-based inquiries into the networked products of the Internet of Things (IoT) lack a coherent understanding of the effect of such products on society. This paper proposes a new taxonomy for networked products, which would allow articulation on their current state and future, and provide insights to designers for creating meaningful and aesthetic products of IoT. Central to this framework is the proposition that our current product-scape should be understood as a distribution of material agencies and best analyzed through the metaphor of "agency". We identify three types of agencies, i.e., the Collector, the Actor, and the Creator, and discuss how this approach could create new design methodologies to create more meaningful networked products that would empower people in their everyday lives.
An Industry-University Partnership to Foster Interdisciplinary Education

Zahed Siddique is a Professor of Mechanical Engineering at the School of Aerospace and Mechanical Engineering of University of Oklahoma. His research interest include product family design, advanced material and engineering education. He is interested in motivation of engineering students, peer-to-peer learning, flat learning environments, technology assisted engineering education and experiential learning. He is the coordinator of the industry sponsored capstone from at his school and is the advisor of OU’s FSAE team.
Can Preference Scores for Discrete States Be Used to Derive Preference Scores for an Entire Path of Events?

The authors conducted a study exploring whether preferences for sequences of events can be approximated by preferences for component discrete states. Visual-analog- scale (VAS) and standard-gamble (SG) scores for a subset of the possible sequences of events (path states) and component temporary and chronic outcomes (discrete states) that can follow prenatal diagnostic decisions were elicited from 121 pregnant women facing a choice between chorionic villus sampling and amniocentesis. For in dividuals, preference scores for path states could not be predicted easily from discrete- state scores. Mean path-state VAS scores, however, were predicted reasonably ac curately by multiple regression models (R2 = 0.85 and 0.82 for two different anchoring schemes), with most measured scores lying within the 95% confidence intervals of the derived scores. It is concluded that, for individual patient decision making, preferences for path states should be elicited. When mean preference values for a population are sought, however, it may be reasonable to derive regression weights from a subset of respondents and then to apply those weights to preferences for discrete states elicited from a larger group. Key words: utility measurement; patient preferences; multiple re gression ; standard gamble; visual analog scaling; prenatal diagnosis. (Med Decis Mak ing 1997;17:42-55))
TRAPPC2L is a Novel, Highly Conserved TRAPP‐Interacting Protein

Mutations in the trafficking protein particle complex C2 protein (TRAPPC2), a mammalian ortholog of yeast Trs20p and a component of the trafficking protein particle (TRAPP) vesicle tethering complex, have been linked to the skeletal disorder spondyloepiphyseal dysplasia tarda (SEDT). Intriguingly, the X‐linked TRAPPC2 is just one of a complement of Trs20‐related genes in humans. Here we characterize TRAPPC2L, a novel, highly conserved TRAPP‐interacting protein related to TRAPPC2 and the uncharacterized yeast open reading frame YEL048c. TRAPPC2L and TRAPPC2 genes are found in pairs across species and show broad and overlapping expression, suggesting they are functionally distinct, a notion supported by yeast complementation studies and biochemical characterization. RNA interference‐mediated knockdown of either TRAPPC2L or TRAPPC2 in HeLa cells leads to fragmentation of the Golgi, implicating both proteins in Golgi dynamics. Gradient fractionation of cellular membranes indicates that TRAPPC2L is found with a portion of cellular TRAPP on very low‐density membranes whereas the remainder of TRAPP, but not TRAPPC2L, is found associated with Golgi markers. YEL048c displays genetic interactions with TRAPP II‐encoding genes and the gene product co‐fractionates with and interacts with yeast TRAPP II. Taken together these results indicate that TRAPPC2L and its yeast ortholog YEL048c are novel TRAPP‐interacting proteins that may modulate the function of the TRAPP II complex.
Dehydroepiandrosterone replacement in healthy men with age-related decline of DHEA-S: effects on fat distribution, insulin sensitivity and lipid metabolism

Many animal and human studies show that supraphysiological doses of dehydroepiandrosterone (DHEA) can influence body composition and carbohydrate and lipid metabolism. Most studies have concentrated on women and have not been randomized, thus creating controversial results. With this in mind, we designed a cross-over double-blind placebo-controlled study of 12 men aged 59.0 ± 4.8 years, who received either 50 mg/24 h DHEA or placebo for 3 months to assess the influence of DHEA on the content and distribution of fat tissue and serum insulin, glucose, total cholesterol, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol levels, as well as testosterone, estradiol, DHEA-sulfate (S), prostate-specific antigen (PSA) concentrations and indexes of insulin sensitivity and resistance. Patients were recruited from university employees attending for periodic health checks, with normal hepatic and renal function with endogenous DHEA-S level < 1500 ng/dl. Our results did not reveal any significant changes in study parameters, apart from a statistically significant increase in DHEA-S levels after therapy with active substance.
Exploring Movie Recommendation System Using Cultural Metadata

With the advent of the World Wide Web, it has captured and accumulated 'Word-of-Mouth (WoM)' such as reviews, comments, user ratings, and etc., about cultural contents including movies. We paid attention to WoMpsilas role as cultural metadata. 'Recommendation systems' are services which recommend users new items such as news articles, books, music, and movies they would like. We developed a simple and low-cost movie recommendation system harnessing vast cultural metadata, about movies, existing on the Web. Then we evaluated the system, and analyzed its strength. As a result, we could be aware of the potential of cultural metadata.
Real-Time Tracking of Athletes in Diving Training Videos

This paper presents a system for real-time tracking of athletes in diving training scenes. The system employs a cascade framework, and only certain regions of interest (ROI) where the athletes could appear are processed. First, background subtraction method is performed in current ROI to extract foreground regions; then, non-human foreground objects such as the springboards are excluded using prior information; next the ROI is modified so that in next frame the athlete would still be in it; finally, a fast curve-fitting algorithm is proposed to get the contour of the athlete. The curve-fitting algorithm is not sensitive to initial curve position and is able to overcome small gaps, which exist commonly in the foreground regions. The system runs at 25 HZ for 720 x 576 color images on a P4 3.0 GHZ PC
Generation of recombinant murine retroviral genomes containing the v-src oncogene: isolation of a virus inducing hemangiosarcomas in the brain

A series of recombinant retroviral genomes was generated by cotransformation of NIH 3T3 cells with a mixture of cloned DNAs: a proviral copy of the wild-type Moloney murine leukemia virus, and Moloney-based vectors containing defective copies of the chicken v-src and the murine v-abl oncogenes. Morphologically transformed foci, appearing at low frequencies in these cultures, released high titers of transforming viruses. Analysis of one group of these viruses showed that the genomes were recombinants containing portions of the viral gag gene juxtaposed to the v-src oncogene. Biologically active cloned DNAs of two of these viruses were obtained and mapped in detail. One of these viruses did not cause disease after inoculation into newborn mice, but the other induced rapidly fatal hemangiosarcomas located exclusively in the brain.
Backpropagation neural networks training for single trial EEG classification

EEG recordings provide an important means of brain-computer communication, but their classification accuracy is limited by unforeseeable signal variations due to artifacts or recognizer-subject feedback. A number of techniques recently have been developed to address the related problem of recognizer robustness to uncontrollable signal variation. In this paper, we propose a classification method entailing time-series EEG signals with backpropagation neural networks (BPNN). To test the improvement in the EEG classification performance with the proposed method, comparative experiments were conducted using Bayesian Linear Discriminant Analysis (BLDA).
In vitro activity of Aloe vera inner gel against Helicobacter pylori strains

Aloe barbadensis Miller (Aloe vera) is a herbal remedy widely used for a variety of illnesses; A. vera leaf extracts have been promoted for detoxification, cure constipation, help flush out toxins and wastes from the body, promote digestion and are used in the treatment of peptic ulcer for cytoprotective action. The aim of this study was to evaluate the antibacterial activity of A. vera inner gel against both susceptible and resistant Helicobacter pylori strains isolated in Abruzzo region, Italy. The inner gel of leaves of a 5‐year‐old plant of A. vera was extracted, homogenized and tested from 800 to 1·56 mg ml−1 against 14 clinical strains and one reference strain of H. pylori using the broth microdilution methodology. Furthermore, the sample of A. vera was investigated for the chemical fingerprint of anthraquinones. The inhibitory concentrations of A. vera inner gel were similar to the bactericidal ones, with values ranging from 6·25 to 800 mg ml−1. Fifty per cent of the detected strains, independently of their susceptibility profile, were inhibited in their growth at 100 mg ml−1. Aloe vera inner gel expresses antibacterial properties against H. pylori and, therefore, in combination with antibiotics, could represent a novel strategy for the treatment of the infection of H. pylori, especially in cases of multiresistance.
Neutrophil chemotaxis and superoxide production are induced by cross-linking FcgammaRII receptors.

Neutrophils express two types of receptor for the Fc region of IgG, FcgammaRII and FcgammaRIIIB. Via these receptors, neutrophils bind IgG complexes that contain more than one IgG molecule. This binding activates functional processes, such as the respiratory burst and chemotaxis. Neutrophils were treated with biotinylated anti-Fc receptor monoclonal antibodies and chemotaxis toward streptavidin, a cross-linking agent, was determined. Cross-linking FcgammaRII and not FcgammaRIIIB induced neutrophil chemotaxis. Superoxide production in response to immobilized anti-Fc receptor antibodies was also examined. Anti-FcgammaRII Fab bound to ELISA plates induced superoxide production, while anti-FcgammaRIIIB Fab did not. Pretreatment of neutrophils with anti-FcgammaRII Fab reduced superoxide generated by immobilized anti-FcgammaRII antibody. The data demonstrate that FcgammaRII and not FcgammaRIIIB are responsible for neutrophil chemotaxis and superoxide production upon Fc receptor activation.
Flexibles: Deformation-Aware 3D-Printed Tangibles for Capacitive Touchscreens

We introduce Flexibles: 3D-printed flexible tangibles that are deformation-aware and operate on capacitive touchscreens. Flexibles add expressive deformation input to interaction with on-screen tangibles. Based on different types of deformation mapping, we contribute a set of 3D-printable mechanisms that capture pressing, squeezing, and bending input with multiple levels of intensities. They can be integrated into 3D printed objects with custom geometries and on different locations. A Flexible is printed in a single pass on a consumer-level 3D printer without requiring further assembly. Through a series of interactive prototypes, example applications and a technical evaluation, we show the technical feasibility and the wide applicability of Flexibles.
Immature dendritic cells reduce proinflammatory cytokine production by a coculture of macrophages and apoptotic cells in a cell‐to‐cell contact‐dependent manner

We have demonstrated that phagocytosis of late apoptotic cells by mouse macrophages leads to the production of proinflammatory cytokines, notably macrophage‐inflammatory protein (MIP‐2), and therefore, a yet‐unknown mechanism(s) should keep our body free of inflammation. In this study, we examined the effect of the addition of immature dendritic cells (iDCs) to a coculture of macrophages and apoptotic cells on MIP‐2 production and phagocytosis by macrophages. The addition of iDCs to the coculture reduced MIP‐2 production significantly but unexpectedly enhanced the phagocytosis by macrophages. Further study revealed that the reduction of MIP‐2 production was dependent on cell‐to‐cell contact partly involving the β2 integrin family Mac‐1. In addition, anti‐inflammatory cytokines, interleukin‐10 and transforming growth factor‐β, were involved in the reduction of MIP‐2 production, as antibodies against these cytokines recovered MIP‐2 production. Both cytokines were expressed by iDCs more sigificantly than macrophages at the mRNA levels, although they were hardly detected in the supernatant at the protein levels, suggesting that minute amounts of these anti‐inflammatory cytokines were produced mainly by iDCs to block MIP‐2 production in a cell‐to‐cell contact‐dependent manner. Thus, this study reveals a new mechanism by which MIP‐2 production by macrophages phagocytosing apoptotic cells is prevented.