Miracle-dz/UniFAR-FTUs huggingface dataset:
Abstract Attribute Exploration with Partial Object Descriptions

Attribute exploration has been investigated in several studies, with particular emphasis on the algorithmic aspects of this knowledge acquisition method. In its basic version the method itself is rather simple and transparent. But when background knowledge and partially described counter-examples are admitted, it gets more difficult. Here we discuss this case in an abstract, somewhat "axiomatic" setting, providing a terminology that clarifies the abstract strategy of the method rather than its algorithmic implementation.
AGE OF ONSET AND NATIVELIKE L2 ULTIMATE ATTAINMENT OF MORPHOSYNTACTIC AND PHONETIC INTUITION

Research has consistently shown there is a negative correlation between age of onset (AO) of acquisition and ultimate attainment (UA) of either pronunciation or grammar in a second language (L2). A few studies have indeed reported nativelike behavior in some postpuberty learners with respect to either phonetics/phonology or morphosyntax, a result that has sometimes been taken as evidence against the critical period hypothesis (CPH). However, in the few studies that have employed a wide range of linguistic tests and tasks, adult learners have not exhibited nativelike L2 proficiency across the board of measures, which, according to some, suggests that the hypothesis still holds. The present study investigated the relationship between AO and UA and the incidence of nativelikeness when measures of phonetic and grammatical intuition are combined. An additional aim was to investigate whether children and adults develop the L2 through fundamentally different brain mechanisms—namely, whether children acquire the language (more) implicitly as an interdependent whole, whereas adults learn it (more) explicitly as independent parts of a whole.
Assessing a culturally appropriate factor structure of the Center for Epidemiologic Studies Depression (CES-D) scale among Japanese Brazilians

Different cultures often express identical symptoms in different ways. The original four-factor structure of the Center for Epidemiologic Studies Depression Scale (CES-D) might not be appropriate for all cultural groups. This study aimed to investigate the factor structure of the CES-D among Japanese Brazilians and to examine relationships between the CES-D and Japanese language proficiency. Participants were Japanese Brazilians (n = 136). Exploratory and confirmatory factor analyses were conducted to determine the structure of the Portuguese CES-D. The relationships were examined using the generalized linear model. We tested the five CES-D models on Japanese Brazilians and found these models did not satisfactory meet goodness-of-fit criteria. Therefore, we performed post-hoc factor analyses on the CES-D and determined a best-fit structure composed of four factors, namely: ‘Depressed Affect/Somatic Symptoms’, ‘Loneliness/Sadness’, ‘(Absence of) Positive Affect’ and ‘Interpersonal Difficulties’. Two items functioned differently from the original model and the structure differed from models developed among Brazilian or Japanese samples. Internal reliability and construct validity were acceptable. Japanese language proficiency, a measure of culture retention, was significantly related to subscores for the absence of positive affect. This suggests a complex relationship between language and cultural background that can affect reporting on instruments such as the CES-D.
Does preference influence performance when reading different sizes of cranial computed tomography?

Abstract. Radiology practice is based on the implicit assumption that the preference for a particular presentation mode goes hand in hand with superior performance. The present experiment tests this assumption in what pertains to image size. Forty-three radiologists were asked to identify intracranial hemorrhages on 20 cranial computed tomography scans in two image sizes, 14×14 and 28×28 cm. They were asked to indicate which size they preferred and subsequently rated each size on a continuous scale in terms of how much they liked them. The results show no correlation between the jackknife free-response receiver operating characteristic figure of merit and preference rated on a continuous scale (large image: r=0.14, p=0.38; small images: r=0.14, p=0.39). Similarly, there was no significant correlation between the time a radiologist took to read a case and preference rated on the continuous scale (large image: r=−0.07, p=0.64; small images: r=−0.04, p=0.80). When dividing radiologists into two groups according to their size preference, there was no significant difference in performance between groups with regard to either large or small images. The results suggest that the preference for an image size and performance with regard to it are not related.
An integrated analysis of olanzapine/fluoxetine combination in clinical trials of treatment-resistant depression.

OBJECTIVE To evaluate the efficacy of olanzapine/fluoxetine combination (OFC) versus olanzapine or fluoxetine monotherapy across all clinical trials of treatment-resistant depression sponsored by Eli Lilly and Company. METHOD Efficacy and safety data from 1146 patients with a history of nonresponse during the current depressive episode who subsequently exhibited nonresponse during a 6- to 8-week antidepressant open-label lead-in phase and were randomly assigned to OFC (N = 462), fluoxetine (N = 342), or olanzapine (N = 342) for double-blind treatment were analyzed. All patients had a diagnosis of major depressive disorder as defined by DSM-III or DSM-IV criteria. The dates in which the trials were conducted ranged from May 1997 to July 2005. RESULTS After 8 weeks, OFC patients demonstrated significantly greater Montgomery-Asberg Depression Rating Scale improvement (mean change = -13.0) than fluoxetine (-8.6, p < .001) or olanzapine (-8.2, p < .001) patients, via a mixed-effects model repeated-measures analysis. Remission rates were 25.5% for OFC, 17.3% (p = .006) for fluoxetine, and 14.0% (p < .001) for olanzapine. Adverse events in >or= 10% of OFC patients were weight gain, increased appetite, dry mouth, somnolence, fatigue, headache, and peripheral edema. Random glucose mean change (mg/dL) was +7.92 for the OFC group, +1.62 for the fluoxetine group (p = .020), and +9.91 for the olanzapine group (p = .485). Random cholesterol mean change (mg/dL) was +12.4 for OFC, +2.3 for fluoxetine (p < .001), and +3.1 for olanzapine (p < .001); incidence of treatment-emergent increase from normal to high cholesterol (baseline < 200 mg/dL and >or= 240 subsequently) was significantly higher for the OFC group (10.2%) than for the fluoxetine group (3.1%, p = .017) but not the olanzapine group (8.0%, p = .569). Mean weight change (kg) was +4.42 for OFC, -0.15 for fluoxetine (p < .001), and +4.63 for olanzapine (p = .381), with 40.4% of OFC patients gaining >or= 7% body weight (vs. olanzapine: 42.9%, p = .515; fluoxetine: 2.3%, p < .001). CONCLUSION Results of this analysis showed that OFC-treated patients experienced significantly improved depressive symptoms compared with olanzapine- or fluoxetine-treated patients following failure of 2 or more antidepressants within the current depressive episode. Safety results for OFC were generally consistent with those for its component monotherapies. The total cholesterol increase associated with OFC was more pronounced than with olanzapine alone.
Alleviating Stress in Clergy Wives

Abstract The psychoeducational group Clergy Wife Wings (CWW) shows good potential in helping non-clergy women married to clergymen to move towards alleviation of ministry-related stress. Qualitative analysis of written documents from group members, leader, and observer reveals themes supporting efficacy and identifying specific strengths, weaknesses, and suggestions. Quantitative analyses of pre and post-group measures on adapted clergy-wife stress instruments do not suggest effectiveness. CWW's theoretical foundations draw from Palmer and Dryden's multimodal model of stress that utilizes A. A. Lazarus's BASIC ID modalities. Methodology consists of formative evaluation of CWW in its first implementation.
Please Scroll down for Article Journal of Homosexuality Exploring the Basis for Gender Differences in the Demand-withdraw Pattern Exploring the Basis for Gender Differences in the Demand-withdraw Pattern

This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, redistribution , reselling , loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. During marital conflict, wives tend to demand and husbands tend to withdraw. These behaviors were historically thought to stem from essential differences between men and women. An alternative explanation implicates one form of power differences—wives desire more change and, therefore, demand; husbands desire less change and withdraw to maintain status quo. Studying same-sex as well as cross-sex couples enables an evaluation of both explanations. We examined demand-withdraw behaviors in 63 heterosexual, gay, and lesbian couples. The demand-withdraw pattern was seen regardless of type of couple. Further, for all couples, differences in the amount of change desired in partners during a conflict interaction predicted differences in demand and withdraw behaviors. These results offer further evidence that an often-observed difference in heterosexual relationships may result from social conventions that afford men greater power and women less power.
Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment

Recent strategies to treat peripheral arterial disease (PAD) have focused on stem cell based therapies, which are believed to result in local secretion of vascular growth factors. Little is known, however, about the role of ischemic endogenous cells in this context. We hypothesized that ischemic muscle cells (MC) are capable of secreting growth factors that act as potent effectors of the local cellular regenerative environment. Both muscle and endothelial cells (ECs) were subjected to experimental ischemia, and conditioned medium (CM) from each was collected and analyzed to assess myogenic and/or angiogenic potential. In muscle progenitors, mRNA expression of VEGF and its cognate receptors (Nrp1, Flt, Flk) was present and decreased during myotube formation in vitro, and EC CM or VEGF increased myoblast proliferation. Angiopoietin-1 (Ang-1), Tie1, and Tie2 mRNA increased during MC differentiation in vitro. Exogenous Ang-1 enhanced myogenic (MyoD and Myogenin) mRNA in differentiating myoblasts and increased myosin heavy chain protein. Myotube formation was enhanced by MC CM and inhibited by EC CM. Ang-1 protein was present in CM from MCs isolated from both the genetically ischemia-susceptible BALB/c and ischemia-resistant C57BL/6 mouse strains, and chimeric Tie2 receptor trapping in situ ablated Ang-1's myogenic effects in vitro. Ang-1 or MC CM enhanced myotube formation in a mixed isolate of muscle progenitors as well as a myoblast co-culture with pluripotent mesenchymal cells (10T1/2) and this effect was abrogated by viral expression of the extracellular domain of Tie2 (AdsTie2). Furthermore, mesh/tube formation by HUVECs was enhanced by Ang-1 or MC CM and abrogated by Tie2 chimeric receptor trapping. Our results demonstrate the ability of muscle and endothelial cell-derived vascular growth factors, particularly Ang-1, to serve as multi-functional stimuli regulating crosstalk between blood vessels and muscle cells during regeneration from ischemic myopathy.
Polyhedral simplification preserving character lines extracted from images

Visualisation, assembling/disassembling simulation, reverse engineering, or finite element analyses are so many applications where a polyhedral simplification can be mandatory. In most of the configurations, such an operation must preserve the significant shapes of the original model. This paper addresses the way these simplifications can be performed while preserving character lines, i.e. those lines which affect significantly the object visual appearance. The proposed simplification process is based on a vertex removal algorithm that uses a heterogeneous map of sizes computed with information extracted from 2D images of the object. The farther the vertices are from the character lines, the more the simplification is important. The geodesic distances are estimated while using a new algorithm based on the analysis of multiple filtering of the images. This method might reduce the computational time since there is no need to compute either the curvature or the saliency. Thus, a first attempt to enrich a polyhedral model with semantic information extracted from images is proposed.
CATALYST: Planning layer directives for effective design closure

For the last several technology generations, VLSI designs in new technology nodes have had to confront the challenges associated with reduced scaling in wire delays. The solution from industrial back-end-of-line process has been to add more and more thick metal layers to the wiring stacks. However, existing physical synthesis tools are usually not effective in handling these new thick layers for design closure. To fully leverage these degrees of freedom, it is essential for the design flow to provide better communication among the timer, the router, and different optimization engines. This work proposes a new algorithm, CATALYST, to perform congestion- and timing-aware layer directive assignment. Our flow balances routing resources among metal stacks so that designs benefit from the availability of thick metal layers by achieving improved timing and buffer usage reduction while maintaining routability. Experiments demonstrate the effectiveness of the proposed algorithm.
Long-Term Weight Change after Initiating Second-Generation Antidepressants

(1) Objective: To examine the relationship between the choice of second-generation antidepressant drug treatment and long-term weight change; (2) Methods: We conducted a retrospective cohort study to investigate the relationship between choice of antidepressant medication and weight change at two years among adult patients with a new antidepressant treatment episode between January, 2006 and October, 2009 in a large health system in Washington State. Medication use, encounters, diagnoses, height, and weight were collected from electronic databases. We modeled change in weight and BMI at two years after initiation of treatment using inverse probability weighted linear regression models that adjusted for potential confounders. Fluoxetine was the reference treatment; (3) Results: In intent-to-treat analyses, non-smokers who initiated bupropion treatment on average lost 7.1 lbs compared to fluoxetine users who were non-smokers (95% CI: −11.3, −2.8; p-value < 0.01); smokers who initiated bupropion treatment gained on average 2.2 lbs compared to fluoxetine users who were smokers (95% CI: −2.3, 6.8; p-value = 0.33). Changes in weight associated with all other antidepressant medications were not significantly different than fluoxetine, except for sertraline users, who gained an average of 5.9 lbs compared to fluoxetine users (95% CI: 0.8, 10.9; p-value = 0.02); (4) Conclusion: Antidepressant drug therapy is significantly associated with long-term weight change at two years. Bupropion may be considered as the first-line drug of choice for overweight and obese patients unless there are other existing contraindications.
The effect of therapeutic drug monitoring on safety and efficacy of voriconazole in invasive fungal infections: a randomized controlled trial.

BACKGROUND Blood levels of voriconazole, a first line therapy for invasive aspergillosis, may correlate with adverse events and treatment response. However, no randomized controlled studies have been conducted to evaluate the clinical utility of routine therapeutic drug monitoring (TDM) of voriconazole. This study aimed to determine whether routine TDM of voriconazole reduces drug adverse events or improves treatment response in invasive fungal infections. METHODS This was a randomized, assessor-blinded, controlled, single center trial. One hundred ten adult patients were randomly assigned to TDM or non-TDM groups. In the TDM group, voriconazole dosage was adjusted (target range, 1.0-5.5 mg/L) according to the serum trough level measured on the fourth day after initiation of voriconazole. The non-TDM group received a fixed, standard dosage. Voriconazole-related adverse events were monitored, and treatment response was assessed three months after the initiation of therapy. RESULTS Baseline characteristics including the CYP2C19 genotype were comparable between the two groups. While the incidence of adverse events was not different between the TDM group and the non-TDM group (both 42%; P = .97), the proportion of voriconazole discontinuation due to adverse events was significantly lower in the TDM group than in the non-TDM group (4% vs 17%; P = .02). A complete or partial response was observed in 81% (30 of 37) of patients in the TDM group compared to 57% (20 of 34) in the non-TDM group (P = .04). CONCLUSIONS Routine TDM of voriconazole may reduce drug discontinuation due to adverse events and improve the treatment response in invasive fungal infections. CLINICAL TRIAL REGISTRATION NCT00890708.
Social Capital and Ethno-Cultural Diverse Immigrants: A Canadian Study on Settlement House and Social Integration

ABSTRACT With ethno-culturally diverse immigrants arriving in constantly increasing numbers, connecting newcomers to residents in the local community is a growing challenge. Settlement houses have traditionally been the “machinery of connection” that bridges such diverse groups. This article reports the results of a study on settlement houses in an urban center located in western Canada. The results show that by embracing bridging as their mission, promoting volunteering, and providing holistic services to meet needs, settlement houses have successfully helped newcomers build cross-group social ties and integrate into the community.
The Influence of Tone, Target, and Issue Ownership on Political Advertising Effects in Primary Versus General Elections

The conventional wisdom in the literature about political advertising effects—e.g., going negative risks backlash, stick to issues your party owns—has been derived from studies of general elections. Much less attention has been paid to primary elections, in which a partisan audience may be receptive to attacks on the opposing party and may judge most issues to be handled better by their own party. This experiment (N = 223) sets out to investigate the roles of tone (positive versus comparative), target (none, primary opponent, or general election opponent), and issue ownership (party-owned issue or unowned issue) in responses to political advertising during primary versus general elections. As predicted, partisans in primary election conditions had lower ad and sponsoring candidate evaluations for comparative ads attacking a primary opponent than for positive ads or comparative ads attacking the eventual general election opponent, but there were no differences between the latter two. Independents in the general election conditions responded more positively to positive ads than comparative ads. Issue ownership had no main effects.
A functionality fault model: feasibility and applications

This paper introduces a functionality fault model and demonstrates its feasibility and advantages. In current designs, the fanin of logic modules implemented in CMOS standard cell, mask-programmable, or field-programmable gate array technology, rarely exceeds 4 on the average. A functionality fault model, based on complete enumeration of the truth table of each logic module, is thus entirely feasible and enhances the quality of the test significantly. Tests based on this model provide complete coverage of module's behavior, interior faults as well as input stuck-at and bridging faults of any multiplicity/spl minus/reducing the need for technology and implementation-specific fault models, The paper also introducer, techniques that lead to efficient implementation of a prototype test generation system and demonstrates its application not only to generate high quality test patterns but also to generate functionality don't cares that can optimize logic and wiring even after mapping a design into a given technology. <<ETX>>
A Comparative Study of performance of Blackman Window Family for Designing Cosine-Modulated Filter Bank

In this work, an improved approach is presented for designing the nearly perfect reconstructed cosine-modulated (CM) filter banks with given stopband attenuation and channel overlapping. The method employs Blackman window family to design the prototype filter for filter banks with novelty of exploiting spline functions in the transition band of the ideal filter instead of using the conventional brick-wall filter. The cutoff frequency is optimized using linear optimization technique such that the filter coefficients values at frequency ( / 2M ω π = ) is approximately equal to 0.707. The simulation results illustrate significant reduction in amplitude distortion, aliasing error and computation time. In case of subband coding of the ECG signals, the proposed method with Blackman window family yields good fidelity performance measuring parameters.
An in silico model for identification of small RNAs in whole bacterial genomes: characterization of antisense RNAs in pathogenic Escherichia coli and Streptococcus agalactiae strains

Characterization of small non-coding ribonucleic acids (sRNA) among the large volume of data generated by high-throughput RNA-seq or tiling microarray analyses remains a challenge. Thus, there is still a need for accurate in silico prediction methods to identify sRNAs within a given bacterial species. After years of effort, dedicated software were developed based on comparative genomic analyses or mathematical/statistical models. Although these genomic analyses enabled sRNAs in intergenic regions to be efficiently identified, they all failed to predict antisense sRNA genes (asRNA), i.e. RNA genes located on the DNA strand complementary to that which encodes the protein. The statistical models enabled any genomic region to be analyzed theorically but not efficiently. We present a new model for in silico identification of sRNA and asRNA candidates within an entire bacterial genome. This model was successfully used to analyze the Gram-negative Escherichia coli and Gram-positive Streptococcus agalactiae. In both bacteria, numerous asRNAs are transcribed from the complementary strand of genes located in pathogenicity islands, strongly suggesting that these asRNAs are regulators of the virulence expression. In particular, we characterized an asRNA that acted as an enhancer-like regulator of the type 1 fimbriae production involved in the virulence of extra-intestinal pathogenic E. coli.