Miracle-dz/UniFAR-FTUs huggingface dataset:
Association between duration of overall and abdominal obesity beginning in young adulthood and coronary artery calcification in middle age.

IMPORTANCE Younger individuals are experiencing a greater cumulative exposure to excess adiposity over their lifetime. However, few studies have determined the consequences of long-term obesity. OBJECTIVE To examine whether the duration of overall and abdominal obesity was associated with the presence and 10-year progression of coronary artery calcification (CAC), a subclinical predictor of coronary heart disease. DESIGN, SETTING, AND PARTICIPANTS Prospective study of 3275 white and black adults aged 18 to 30 years at baseline in 1985-1986 who did not initially have overall obesity (body mass index [BMI] ≥30) or abdominal obesity (men: waist circumference [WC] >102 cm; women: >88 cm) in the multicenter, community-based Coronary Artery Risk Development in Young Adults (CARDIA) study. Participants completed computed tomography scanning for the presence of CAC during the 15-, 20-, or 25-year follow-up examinations. Duration of overall and abdominal obesity was calculated using repeat measurements of BMI and WC, respectively, performed 2, 5, 7, 10, 15, 20, and 25 years after baseline. MAIN OUTCOMES AND MEASURES Presence of CAC was measured by computed tomography at the year 15 (2000-2001), year 20 (2005-2006), or year 25 (2010-2011) follow-up examinations. Ten-year progression of CAC (2000-2001 to 2010-2011) was defined as incident CAC in 2010-2011 or an increase in CAC score of 20 Agatston units or greater. RESULTS During follow-up, 40.4% and 41.0% developed overall and abdominal obesity, respectively. Rates of CAC per 1000 person-years were higher for those who experienced more than 20 years vs 0 years of overall obesity (16.0 vs 11.0, respectively) and abdominal obesity (16.7 vs 11.0). Approximately 25.2% and 27.7% of those with more than 20 years of overall and abdominal obesity, respectively, experienced progression of CAC vs 20.2% and 19.5% of those with 0 years. After adjustment for BMI or WC and potential confounders, the hazard ratios for CAC for each additional year of overall or abdominal obesity were 1.02 (95% CI, 1.01-1.03) and 1.03 (95% CI, 1.02-1.05), respectively. The adjusted odds ratios for CAC progression were 1.04 (95% CI, 1.01-1.06) and 1.04 (95% CI, 1.01-1.07), respectively. Associations were attenuated but largely persisted following additional adjustment for potential intermediate metabolic factors during follow-up. CONCLUSIONS AND RELEVANCE Longer duration of overall and abdominal obesity was associated with subclinical coronary heart disease and its progression through midlife independent of the degree of adiposity. Preventing or at least delaying the onset of obesity in young adulthood may lower the risk of developing atherosclerosis through middle age.
Self Exploration of Sensorimotor Spaces in Robots.

Developmental robotics has begun in the last fifteen years to study robots that havea childhood—crawling before trying to run, playing before being useful—and that are basing their decisions upon a lifelong and embodied experience of the real-world. In this context, this thesis studies sensorimotor exploration—the discovery of a robot’s own body and proximal environment—during the early developmental stages, when no prior experience of the world is available. Specifically, we investigate how to generate a diversity of effects in an unknown environment. This approach distinguishes itself by its lack of user-defined reward or fitness function, making it especially suited for integration in self-sufficient platforms. In a first part, we motivate our approach, formalize the exploration problem, define quantitative measures to assess performance, and propose an architectural framework to devise algorithms. through the extensive examination of a multi-joint arm example, we explore some of the fundamental challenges that sensorimotor exploration faces, such as high-dimensionality and sensorimotor redundancy, in particular through a comparison between motor and goal babbling exploration strategies. We propose several algorithms and empirically study their behaviour, investigating the interactions with developmental constraints, external demonstrations and biologicallyinspired motor synergies. Furthermore, because even efficient algorithms can provide disastrous performance when their learning abilities do not align with the environment’s characteristics, we propose an architecture that can dynamically discriminate among a set of exploration strategies. Even with good algorithms, sensorimotor exploration is still an expensive proposition— a problem since robots inherently face constraints on the amount of data they are able to gather; each observation takes a non-negligible time to collect. [. ] Throughout this thesis, our core contributions are algorithms description and empirical results. In order to allow unrestricted examination and reproduction of all our results, the entire code is made available. Sensorimotor exploration is a fundamental developmental mechanism of biological systems. By decoupling it from learning and studying it in its own right in this thesis, we engage in an approach that casts light on important problems facing robots developing on their own.
HOTS: A Hierarchy of Event-Based Time-Surfaces for Pattern Recognition

This paper describes novel event-based spatio-temporal features called time-surfaces and how they can be used to create a hierarchical event-based pattern recognition architecture. Unlike existing hierarchical architectures for pattern recognition, the presented model relies on a time oriented approach to extract spatio-temporal features from the asynchronously acquired dynamics of a visual scene. These dynamics are acquired using biologically inspired frameless asynchronous event-driven vision sensors. Similarly to cortical structures, subsequent layers in our hierarchy extract increasingly abstract features using increasingly large spatio-temporal windows. The central concept is to use the rich temporal information provided by events to create contexts in the form of time-surfaces which represent the recent temporal activity within a local spatial neighborhood. We demonstrate that this concept can robustly be used at all stages of an event-based hierarchical model. First layer feature units operate on groups of pixels, while subsequent layer feature units operate on the output of lower level feature units. We report results on a previously published 36 class character recognition task and a four class canonical dynamic card pip task, achieving near 100 percent accuracy on each. We introduce a new seven class moving face recognition task, achieving 79 percent accuracy.
Analysis of the Petunia TM 6 MADS Box Gene Reveals Functional Divergence within the DEF / AP 3 Lineage

Antirrhinum majus DEFICIENS (DEF) and Arabidopsis thaliana APETALA3 (AP3) MADS box proteins are required to specify petal and stamen identity. Sampling of DEF/AP3 homologs revealed two types of DEF/AP3 proteins, euAP3 and TOMATO MADS BOX GENE6 (TM6), within core eudicots, and we show functional divergence in Petunia hybrida euAP3 and TM6 proteins. Petunia DEF (also known as GREEN PETALS [GP]) is expressed mainly in whorls 2 and 3, and its expression pattern remains unchanged in a blind (bl) mutant background, in which the cadastral C-repression function in the perianth is impaired. Petunia TM6 functions as a B-class organ identity protein only in the determination of stamen identity. Atypically, Petunia TM6 is regulated like a C-class rather than a B-class gene, is expressed mainly in whorls 3 and 4, and is repressed by BL in the perianth, thereby preventing involvement in petal development. A promoter comparison between DEF and TM6 indicates an important change in regulatory elements during or after the duplication that resulted in euAP3and TM6-type genes. Surprisingly, although TM6 normally is not involved in petal development, 35S-driven TM6 expression can restore petal development in a def (gp) mutant background. Finally, we isolated both euAP3 and TM6 genes from seven solanaceous species, suggesting that a dual euAP3/TM6 B-function system might be the rule in the Solanaceae.
Classification of remote sensing image data fusion considering spatial information

Classification is an important application in remote sensing image process, but classification accuracy about non-normal distribution of samples is lower when using traditional methods of probability and statistical. Evidence theory can combine certain and uncertain information of multi-source remote sensing images to achieve effective identification of the images. Taking the results which go through training of neural network as evidence can combine the neural network with the evidence theory, and then integrate their advantages to get better classification results. In the paper, we proposed the classification of remote sensing image decision-level data fusion considering spatial information, and took the panchromatic image with plentiful spatial information into classification decision to reduce uncertainty, and to improve the classification accuracy.
Human Action Recognition in Still Images using Bag of Latent Poselets

In this paper we proposed a new method for the prob lem of structural human action recognition in single image s. In this work, we first extract all Poselets in the images f or using as the descriptor of human’s activity. Then, we model th latent topics of human poses by using extracted vectors an d P-LSA. Finally recognize human’s action in a query image b y using the trained SVM on the extracted bag of latent Pose let . We tested our method on PASCAL VOC2010 action classifi cation dataset and the results show the significant improv ements in some action classes such as Walking and Running.
The mechanical behavior of the lungs in healthy elderly persons.

In a previous study it was found that the elastic properties of lungs appeared to be unaffected by age in healthy adults 17 to 39 years old (1). The slope of the static volume-pressure curve of lungs in the resting tidal range of breathing was used as a measure of pulmonary compliance. The present study extends observations to adults 50 years and older. To obtain a more complete description of the elastic behavior of lungs, static transpulmonary pressure has been related to the total volume of gas in the lungs, and the range of volume change has been extended from that of tidal volume to inspiratory capacity. In addition, measurement has also been made of pulmonary compliance at various rates of breathing, and of pulmonary flow resistance. Finally, these data have been compared with findings in young adults.
Non-invasive neural stem cells become invasive in vitro by combined FGF2 and BMP4 signaling

Summary Neural stem cells (NSCs) typically show efficient self-renewal and selective differentiation. Their invasion potential, however, is not well studied. In this study, Sox2-positive NSCs from the E14.5 rat cortex were found to be non-invasive and showed only limited migration in vitro. By contrast, FGF2-expanded NSCs showed a strong migratory and invasive phenotype in response to the combination of FGF2 and BMP4. Invasive NSCs expressed Podoplanin (PDPN) and p75NGFR (Ngfr) at the plasma membrane after exposure to FGF2 and BMP4. FGF2 and BMP4 together upregulated the expression of Msx1, Snail1, Snail2, Ngfr, which are all found in neural crest (NC) cells during or after epithelial–mesenchymal transition (EMT), but not in forebrain stem cells. Invasive cells downregulated the expression of Olig2, Sox10, Egfr, Pdgfra, Gsh1/Gsx1 and Gsh2/Gsx2. Migrating and invasive NSCs had elevated expression of mRNA encoding Pax6, Tenascin C (TNC), PDPN, Hey1, SPARC, p75NGFR and Gli3. On the basis of the strongest upregulation in invasion-induced NSCs, we defined a group of five key invasion-related genes: Ngfr, Sparc, Snail1, Pdpn and Tnc. These genes were co-expressed and upregulated in seven samples of glioblastoma multiforme (GBM) compared with normal human brain controls. Induction of invasion and migration led to low expression of differentiation markers and repressed proliferation in NSCs. Our results indicate that normal forebrain stem cells have the inherent ability to adopt a glioma-like invasiveness. The results provide a novel in vitro system to study stem cell invasion and a novel glioma invasion model: tumoral abuse of the developmental dorsoventral identity regulation.
Augmentation of Clozapine with Aripiprazole in Severe Psychotic Bipolar and Schizoaffective Disorders: A Pilot Study

Aim: To evaluate the efficacy and safety of the augmentation of clozapine with aripiprazole in patients with treatment-resistant schizoaffective and psychotic bipolar disorders in a retrospective manner. Pharmacodynamic and pharmacokinetic interactions between the two drugs were also investigated. Patients: Three men and 4 women (median age 36 and 40 years, respectively) who had mean scores at BPRS and CGI-Severity of 59.1±12.0 and 5.4±0.5, respectively, were treated with clozapine (mean dose 292.9±220.7 mg/day). Patients received an adjunctive treatment with aripiprazole (mean dose 6.8 ± 3.7 mg/day). Clozapine, norclozapine and aripiprazole plasma levels were measured by means of a high performance liquid chromatograpy with UV detection. Results: Total scores at BPRS decreased significantly (from 59.1±12.0 to 51.1±15.6, p=0.007) after aripirazole augmentation. In particular, the factors “thought disorder” (from 10.4±4.4 to 9.0±4.5, p=.047) and “anergia” (from 10.0±2.7 to 8.0±2.4, p=.018) significantly improved. Concomitant administration of aripiprazole and clozapine did not result in an increase in side effects over the period of treatment. Dose-normalized plasma levels of both clozapine and norclozapine and the clozapine/norclozapine metabolic ratio in all patients did not vary as well. Conclusion: The augmentation of clozapine with aripirazole was safe and effective in severe psychotic schizoaffective and bipolar disorders which failed to respond to atypical antipsychotics. A possible pharmacokinetic interaction between clozapine and aripiprazole does not account for the improved clinical benefit obtained after aripiprazole augmentation.
The Cover Time of Random Regular Graphs

Let $r \ge 3$ be constant, and let ${\cal G}_{r}$ denote the set of r-regular graphs with vertex set V = {1,2,. ,n}. Let G be chosen randomly from ${\cal G}_{r}$. We prove that with high probability (\whp) the cover time of a random walk on G is asymptotic to $\frac{r-1}{r-2}\;n\log n$.
Parent Perceptions of Children's Leisure and the Risk of Damaging Noise Exposure†

Abstract The purpose of this study was to survey the attitudes of parents of adolescent children (with, and without, hearing impairment), with the following objectives: (1) compare perceptions of the parent groups regarding the risk of leisure-noise-related hearing injury; and (2) investigate how comfortable parents felt endorsing their child's participation in a range of everyday leisure activities, some which may involve noise exposure. Cross-sectional cohort study. Experimental group — parents of adolescents (aged 13–18 years) with hearing impairment (HI group) n = 53. Control group — parents of age-matched youths with non-impaired/‘normal hearing’ (NH group) n = 70. Rasch modelling was applied to evaluate the internal validity and reliability of the leisure attitudes items. Rasch-generated interval-level data and raw ordinal-level data were used to identify systematic differences between groups. Most parents (HI and NH groups) perceived leisure-noise to be a significant health risk for young people in general, but few perceived their own child to be at high risk. Parents in the HI group were significantly less comfortable overall, and with several specific leisure activities, than parents in the NH group but, conversely, were more comfortable with two activities. Concerns related to a variety of factors. Leisure-time activities provide a major opportunity for children to socialize and they are a crucial part of healthy emotional and physical development. Parent attitudes may influence children's participation. Parents may benefit from support in identifying and managing concerns about the impact of hearing impairment on their children's leisure participation.
A fast index method for moving objects on full temporal query

Moving object index method is the key technology for moving object data base, the performance of which determines the efficiency of the whole data base system. Upon the request for temporal query, this article focuses on moving object index for full temporal query, proposes a moving object index structure FT tree for temporal query, invites theories of various versions into TPR tree, improves the TPR tree that supports future query, and keeps various versions of TPR tree effectively to realize past, present and future temporal query.
Physiotherapy after traumatic brain injury: A systematic review of the literature

Primary objectives: At present there are no standardized recommendations concerning physiotherapy of individuals with traumatic brain injury (TBI) resulting in a high variability of methods and intensity. The aim of this literature review is to develop recommendations concerning physiotherapy in the post-acute phase after TBI on the basis of scientific evidence. Method: literature review: data bases: PubMed, PEDro, OT-Seeker, Cochrane and Cinahl. Keywords: brain injury (in PEDro, OT-Seeker, Cochrane), brain injury AND physical therapy (in PubMed and Cinahl). Results: Fourteen studies met the inclusion criteria and were grouped into sub-groups: sensory stimulation, therapy intensity, casting/splinting, exercise or aerobic training and functional skill training. While for sensory stimulation evidence could not be proven, a strong evidence exists that more intensive rehabilitation programmes lead to earlier functional abilities. The recommendation due to casting for the improvement of passive range of motion is a grade B, while only a C recommendation is appropriate concerning tonus reduction. Strong evidence exists that intensive task-orientated rehabilitation programmes lead to earlier and better functional abilities. Conclusion: Although some recommendations for the effectiveness of physical therapy interventions could be expressed, there are many questions concerning the treatment of humans with TBI which have not been investigated so far. Especially on the level of activity and participation only a few studies exist.
Meta-Blocking: Taking Entity Resolutionto the Next Level

Entity Resolution is an inherently quadratic task that typically scales to large data collections through blocking. In the context of highly heterogeneous information spaces, blocking methods rely on redundancy in order to ensure high effectiveness at the cost of lower efficiency (i.e., more comparisons). This effect is partially ameliorated by coarse-grained block processing techniques that discard entire blocks either a-priori or during the resolution process. In this paper, we introduce meta-blocking as a generic procedure that intervenes between the creation and the processing of blocks, transforming an initial set of blocks into a new one with substantially fewer comparisons and equally high effectiveness. In essence, meta-blocking aims at extracting the most similar pairs of entities by leveraging the information that is encapsulated in the block-to-entity relationships. To this end, it first builds an abstract graph representation of the original set of blocks, with the nodes corresponding to entity profiles and the edges connecting the co-occurring ones. During the creation of this structure all redundant comparisons are discarded, while the superfluous ones can be removed by pruning of the edges with the lowest weight. We analytically examine both procedures, proposing a multitude of edge weighting schemes, graph pruning algorithms as well as pruning criteria. Our approaches are schema-agnostic, thus accommodating any type of blocks. We evaluate their performance through a thorough experimental study over three large-scale, real-world data sets, with the outcomes verifying significant efficiency enhancements at a negligible cost in effectiveness.
Deformation Sensitive Decimation

In computer graphics, many automatic methods for simplifying polygonal meshes have been developed. These techniques work very well for static meshes; however, they do not handle the case of deforming objects. Simplifying any single pose of a deforming object may destroy detail required to represent the shape in a different pose. We present an automatic technique for simplifying deforming character meshes that takes a set of examples as input and produces a set of simplied examples as output. The method preserves detail required for deformation and maintains connectivity information across the examples. This technique is applicable to many current skinning algorithms including example-driven techniques, tting techniques and Linear Blend Skinning.
Evidence for a Gene Influencing Blood Pressure on Chromosome 17: Genome Scan Linkage Results for Longitudinal Blood Pressure Phenotypes in Subjects From the Framingham Heart Study

Hypertension is a leading cause of morbidity and mortality. Efforts to identify hypertension genes have focused on 3 approaches: mendelian disorders, candidate genes, and genome-wide scans. Thus far, these efforts have not identified genes that contribute substantively to overall blood pressure (BP) variation in the community. A 10-centiMorgan (cM) density genome-wide scan was performed in the largest families from 2 generations of Framingham Heart Study participants. Heritability and linkage for long-term mean systolic and diastolic BP phenotypes were analyzed by use of solar software. Heritability estimates were based on BP measurements in 1593 families. Genotyping was performed on 1702 subjects from 332 large families, and BP data were available for 1585 (93%) genotyped subjects who contributed 12 588 longitudinal BP observations. The mean age was 47 years, and mean BP was 127/80 (systolic/diastolic) mm Hg. Long-term systolic and diastolic BP phenotypes had high heritability estimates, 0.57 and 0.56, respectively. For systolic BP, multipoint log-of-the-odds (LOD) scores >2.0 were located on chromosome 17 at 67 cM (LOD 4.7, P =0.0000016) and 94 cM (LOD 2.2). For diastolic BP, LOD scores >2.0 were identified on chromosome 17 (74 cM, LOD 2.1) and chromosome 18 (7 cM, LOD 2.1). Using a genome-wide scan, we found strong evidence for a BP quantitative trait locus on chromosome 17. Follow-up studies are warranted to identify the gene or genes in this quantitative trait locus that influence BP. Such knowledge could extend our understanding of the genetic basis of essential hypertension and have implications for the evaluation and treatment of patients with high BP.
PHYLETIC HOT SPOTS FOR B CHROMOSOMES IN ANGIOSPERMS

Abstract We determined whether supernumerary B chromosomes were nonrandomly distributed among major angiosperm lineages and among lineages within families, as well as the identity of lineages with unusually high B-chromosome frequencies (hot spots). The incidence of B chromosomes for each taxon was gathered from databases showing species with and without these chromosomes (among species with known chromosome numbers). Heterogeneity was found at all ranks above the species level. About 8% of monocots had B chromosomes versus 3% for eudicots; they were rare in nonmonocot basal angiosperms. Significant heterogeneity in B-chromosome frequency occurred among related orders, families within orders, and major taxa within families. There were many B-chromosome hot spots, including Liliales and Commelinales at the order level. At the family level, there was a trend suggesting that B-chromosome frequencies are positively correlated with genome size.