Miracle-dz/UniFAR-FTUs huggingface dataset:
HISTONE DEACETYLASE19 Interacts with HSL1 and Participates in the Repression of Seed Maturation Genes in Arabidopsis Seedlings[C][W]

HDA19 interacts with HSL1 and together they negatively regulate seed maturation gene expression in vegetative organs, suggesting that epigenetic regulation is critical for seed development. This study provides insight into the molecular mechanism underlying the gene regulation in seed development. The seed maturation genes are specifically and highly expressed during late embryogenesis. In this work, yeast two-hybrid, bimolecular fluorescence complementation, and coimmunoprecipitation assays revealed that HISTONE DEACETYLASE19 (HDA19) interacted with the HIGH-LEVEL EXPRESSION OF SUGAR-INDUCIBLE GENE2-LIKE1 (HSL1), and the zinc-finger CW [conserved Cys (C) and Trp (W) residues] domain of HSL1 was responsible for the interaction. Furthermore, we found that mutations in HDA19 resulted in the ectopic expression of seed maturation genes in seedlings, which was associated with increased levels of gene activation marks, such as Histone H3 acetylation (H3ac), Histone H4 acetylation (H4ac), and Histone H3 Lys 4 tri-methylation (H3K4me3), but decreased levels of the gene repression mark Histone H3 Lys 27 tri-methylation (H3K27me3) in the promoter and/or coding regions. In addition, elevated transcription of certain seed maturation genes was also found in the hsl1 mutant seedlings, which was also accompanied by the enrichment of gene activation marks but decreased levels of the gene repression mark. Chromatin immunoprecipitation assays showed that HDA19 could directly bind to the chromatin of the seed maturation genes. These results suggest that HDA19 and HSL1 may act together to repress seed maturation gene expression during germination. Further genetic analyses revealed that the homozygous hsl1 hda19 double mutants are embryonic lethal, suggesting that HDA19 and HSL1 may play a vital role during embryogenesis.
VLSI implementation of MIMO detection using the sphere decoding algorithm

Multiple-input multiple-output (MIMO) techniques are a key enabling technology for high-rate wireless communications. This paper discusses two ASIC implementations of MIMO sphere decoders. The first ASIC attains maximum-likelihood performance with an average throughput of 73 Mb/s at a signal-to-noise ratio (SNR) of 20 dB; the second ASIC shows only a negligible bit-error-rate degradation and achieves a throughput of 170 Mb/s at the same SNR. The three key contributing factors to high throughput and low complexity are: depth-first tree traversal with radius reduction, implemented in a one-node-per-cycle architecture, the use of the /spl lscr//sup /spl infin//-instead of /spl lscr//sup 2/-norm, and, finally, the efficient implementation of the enumeration approach recently proposed in . The resulting ASICs currently rank among the fastest reported MIMO detector implementations.
Sex‐biased natal dispersal and inbreeding avoidance in American black bears as revealed by spatial genetic analyses

We tested the hypothesis that sex‐biased natal dispersal reduces close inbreeding in American black bears, a solitary species that exhibits nearly complete male dispersal and female philopatry. Using microsatellite DNA and spatial data from reproductively mature bears (≥ 4 years old), we examined the spatial genetic structure of two distinct populations in New Mexico from 1993 to 2000. As predicted, relatedness (r) and the frequency of close relationships (parent–offspring or full siblings) decreased with distance among female dyads, but little change was observed among male or opposite‐sex dyads. Neighbouring females were more closely related than neighbouring males. The potential for inbreeding was low. Most opposite‐sex pairs that lived sufficiently close to facilitate mating were unrelated, and few were close relatives. We found no evidence that bears actively avoided inbreeding in their selection of mates from this nearby pool, as mean r and relationship frequencies did not differ between potential and actual mating pairs (determined by parentage analysis). These basic patterns were apparent in both study areas despite a nearly two‐fold difference in density. However, the sex bias in dispersal was less pronounced in the lower‐density area, based on proportions of bears with male and female relatives residing nearby. This result suggests that male bears may respond to reduced competition by decreasing their rate or distance of dispersal. Evidence supports the hypothesis that inbreeding avoidance is achieved by means of male‐biased dispersal but also indicates that competition (for mates or resources) modifies dispersal patterns.
Orthodontic miniscrew failure rate and root proximity, insertion angle, bone contact length, and bone density.

OBJECTIVES To test the hypothesis that there is no significant correlation between miniscrew failure rate and root proximity, insertion angle, bone contact length, and bone density. SETTING AND SAMPLE POPULATION This study included 107 patients in whom 190 miniscrews had been placed from April 2008 to October 2009 in Tohoku University Hospital (Sendai, Japan). MATERIALS AND METHODS Cone beam computed tomography scans (CBCT) and periapical radiographs were taken before and after miniscrew placement. Differences in root proximity, screw insertion angle, bone contact length, and bone density were statistically compared; comparisons were also made between the CBCT images and periapical radiographs. RESULTS A significantly higher success rate was observed in the maxilla than in the mandible. The distance between the miniscrew and the root surface was significantly smaller in the failure group. There were no significant differences in the insertion angle, bone contact length, or bone density between the success group and the failure group. The concordance rate between the periapical dental radiographs and CBCT images was 46.5%. CONCLUSION While bone contact length, miniscrew angle, and bone density did not exert major effects on miniscrew failure, root proximity was the factor that most affected miniscrew failure, especially for miniscrews placed in the mandible. CBCT was superior to periapical dental X-rays for evaluating the proximity of miniscrews to the root. Correction of the X-ray attenuation coefficient value was necessary for measuring bone density using CBCT.
Prevalence and factors related to inappropriately high left ventricular mass in patients with rheumatoid arthritis without overt cardiac disease

Objectives: Due to the chronic inflammatory status, specific neuro-hormones and progression of arterial stiffness, patients with rheumatoid arthritis (RA) are exposed to the development of excessive left ventricular mass disproportionate to the need to compensate left ventricular load. This condition, named inappropriately high left ventricular mass (iLVM), is associated with unfavorable prognosis in patients with hypertension, aortic stenosis or diabetes. In this study, we assessed prevalence and factors associated with iLVM in a large cohort of patients with RA and tested the hypothesis that RA per se is a condition related to iLVM. Methods: We prospectively analyzed 235 RA patients without overt cardiac disease recruited between January and December 2014, who were compared with 235 controls matched for age, sex, BMI, prevalence of hypertension and diabetes. iLVM was defined as measured/predicted LVM ratio above 123%. LVM was predicted in each individual by using a simple equation considering height, sex and left ventricular work. Results: iLVM was detected in 150 RA patients (64%) and in 30 controls (15%; P < 0.001). In patients with RA, the variables independently associated with iLVM emerged by multivariate logistic regression analysis were left ventricular systolic dysfunction measured as mid-wall shortening and concentric left ventricular geometry. Considering both groups of patients with RA and matched controls, RA was the strongest variable related to iLVM (odds ratio 3.37, 95% confidence interval 1.37–8.31, P = 0.008). Conclusions: Two-thirds of patients with RA without overt cardiac disease have iLVM, which is associated with left ventricular systolic dysfunction and concentric geometry. RA per se is a condition closely related to iLVM.
Strong authentication with mobile phone as security token

The protection of digital identities is getting more and more crucial. The usage of passwords for authentication is no longer sufficient and stronger authentication schemes are necessary. Strong authentication solutions using two identification factors require often an additional device, which could be inconvenient for the user and costly for the service providers. To avoid the usage of additional device, the mobile phone is adopted as security token. This paper provides a study of the various ways the mobile phone can be used as an authentication token towards service providers on the Internet. It starts with discussing the need for a strong authentication scheme, and the motivation for using the mobile phone to improve on several aspects of the current authentication processes. Thereafter, the general architecture for authentication with mobile phones is presented. Several different authentication solutions using the mobile phone as authentication token are then described, where the solutions vary in complexity, strength and user-friendliness. The paper ends with an evaluation of the different solutions, and a discussion of the most probable attacks. A classification of the solutions is also provided, according to defined criteria.
Crucial role of the orexin‐B C‐terminus in the induction of OX1 receptor‐mediated apoptosis: analysis by alanine scanning, molecular modelling and site‐directed mutagenesis

Orexins (A and B) are hypothalamic peptides that interact with OX1 and OX2 receptors and are involved in the sleep/wake cycle. We previously demonstrated that OX1 receptors are highly expressed in colon cancer tumours and colonic cancer cell lines where orexins induce apoptosis and inhibit tumour growth in preclinical animal models. The present study explored the structure–function relationships of orexin‐B and OX1 receptors.
Household‐level predictors of maternal mental health and systemic inflammation among infants in Mwanza, Tanzania

Household conditions and culturally/socially variable childcare practices influence priming of the inflammatory response during infancy. Maternal mental health may partially mediate that effect. Among mother–infant dyads in Mwanza, Tanzania, we hypothesized that poorer maternal mental health would be associated with adverse household ecology, lower social capital, and greater inflammation among infants under the age of one; and that mental health would mediate any effects of household ecology/social capital on inflammation.
Checkpoint-recovery for mobile computing systems

Recent information systems consist of mobile stations and fixed stations. Mission-critical applications are required to be executed fault-tolerantly. However, mobile stations support neither enough volume of storage, processing power nor capacity of battery to support reliable communication and computation. A hybrid checkpoint protocol for mobile computing systems is proposed. In this protocol, mobile-to-mobile communication is not supported. Thus, we propose an extended hybrid checkpoint protocol for mobile-to-mobile communication in wireless LAN protocols such as IEEE 802.11 and HIPERLAN. Compared with the conventional protocol, the proposed protocol is realized by only piggy-backing some information without additional messages.
Volumetric Data Reduction in a Compressed Sensing Framework

In this paper, we investigate compressed sensing principles to devise an in‐situ data reduction framework for visualization of volumetric datasets. We exploit the universality of the compressed sensing framework and show that the proposed method offers a refinable data reduction approach for volumetric datasets. The accurate reconstruction is obtained from partial Fourier measurements of the original data that are sensed without any prior knowledge of specific feature domains for the data. Our experiments demonstrate the superiority of surfacelets for efficient representation of volumetric data. Moreover, we establish that the accuracy of reconstruction can further improve once a more effective basis for a sparser representation of the data becomes available.
Recent Results from the Study of Emittance Evolution in MICE

The Muon Ionization Cooling Experiment (MICE) was designed to demonstrate a measurable reduction in beam emittance due to ionization cooling. The emittance of a variety of muon beams was reconstructed before and after a “cooling cell”, allowing the change in the phase-space distribution due to the presence of an absorber to be measured. The core of the MICE experiment is a cooling cell that can contain a range of solid and cryogenic absorbers inside a focussing solenoid magnet. For the data described here, a single lithium hydride (LiH) absorber was installed and two different emittance beam have been analysed. Distributions that demonstrate emittance increase and equilibrium have been reconstructed, in agreement with theoretical predictions. Data taken during 2016 and 2017 is currently being analysed to evaluate the change in emittance with a range of absorber materials, different initial emittance beams and various magnetic lattice settings. The current status and the most recent results of these analyses is presented.
Building Self-Managing Web Information Systems from Generic Components

The increasing need for device independence and personalization forces organizations to automatically adapt their Web Information Systems (WISs) to individual users and their client platforms. Moreover, the Web’s evolution to a dynamic interaction medium also requires such WISs to be self-adaptive, i.e. to dynamically adjust themselves to a constantly changing reality. Still, there are no generic software components to manage this multitude of adaptation aspects. This paper presents the Self-Adapting GAC (SAG), a generic component for realizing self-managing adaptive WISs. It has the capability to perform adaptive data transformations, but it can also dynamically reconfigure itself to the current situation. For configuring the SAG an RDF-based rule language is introduced, providing rules for both content adaptation and self-configuration. Moreover, based on the modular document generation architecture of the AMACONT project an implementation of the SAG is provided. The resulting architecture is explained in detail and elucidated by a running example prototype.
Heavy drinking days and mental health: an exploration of the dynamic 10-year longitudinal relationship in a prospective cohort of untreated heavy drinkers.

BACKGROUND Identifying dominant processes that underlie the development of other processes is important when evaluating the temporal sequence between disorders. Such information not only improves our understanding of etiology but also allows for effective intervention strategies to be tailored. The temporal relationship between alcohol intake and mental health remains poorly understood, particularly in nonclinical samples. The purpose of this study was to disentangle the dominant temporal sequence between mental health and frequency of heavy drinking days. METHODS We report a 10-year (1997 to 2007) prospective cohort study of 500 respondents (74% male) from the Birmingham Untreated Heavy Drinkers project. Participants were aged 25 to 55 years at baseline, drinking a minimum of 50/35 U.K. units of alcohol for men/women on a weekly basis, and were not seeking treatment for their alcohol use upon recruitment into the study. Heavy drinking days were defined as consuming 10/7+ U.K. units of alcohol in a single day for men/women. Mental health was assessed using the mental health component score of the SF-36 questionnaire. Dynamic longitudinal structural equation models were used to test competing theoretical models (frequency of heavy drinking days leading to changes in mental health scores and vice versa) and a reciprocal relationship (both mental health scores and the frequency of heavy drinking days influencing changes in each other). RESULTS A model whereby mental health scores were predictors of change in the frequency of heavy drinking days was of best fit. In this model, mental health scores were negatively related to change in heavy drinking days (β -0.80, SE 0.28) indicating that those with higher mental health scores (i.e., better functioning) made larger reductions in the number of heavy drinking days over time. CONCLUSIONS Mental health appears to be the stronger underlying process in the relationship between mental health and frequency of heavy drinking days.
Challenge-based clinical patterns of 223 Spanish patients with nonsteroidal anti-inflammatory-drug-induced-reactions.

BACKGROUND The single-blind, placebo controlled oral challenge (SBPCOC) is the definitive way to diagnosis nonsteroidal anti-inflammatory drug (NSAID)-induced reactions. OBJECTIVE To evaluate 223 NSAID-sensitive patients by means of SBPCOC, and to describe the main clinical patterns found. METHODS A prospective study was carried out, including 2 patient groups with case histories consistent with NSAID-induced reactions. Of the 223 patients, 174 were diagnosed on the basis of a positive SBPCOC. The second group consisted of 49 patients who were referred because of a documented history of anaphylaxis after taking NSAIDs, and these underwent SBPCOC with potent cyclooxygenase (COX)-1/COX-2 inhibitors, except those reported as being responsible for the reaction. The type of SBPCOC reaction, the NSAID reactivity pattern, and the associated diseases were the main classification criteria. RESULTS Two broad categories of NSAID-induced reactions were identified: the cross-reactive and selective syndromes. The 150 patients who showed cross-reactive syndromes included 3 types of diseases: type 1, patients with rhinitis and/or asthma who developed nasoocular and/or asthmatic reactions (n=40); type 2, patients with or without chronic urticaria who presented urticaria/angioedema (n=59); and type 3, atopic patients with isolated periorbital angioedema (n=51). In contrast, the selective syndromes, or type 4, included 50 patients who developed anaphylaxis, as well as 11 patients with urticaria during SBPCOC. Finally, a miscellaneous group of reactions not matching any of the above types was identified (n=1 2). CONCLUSIONS NSAID-sensitive patients can be classified into 4 different groups of reactors, each with well-defined clinical characteristics. Thus, a clinical classification of this NSAID-induced reaction complex is proposed.
Stem cell‐based cell therapy in neurological diseases: A review

Human neurological disorders such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, multiple sclerosis (MS), stroke, and spinal cord injury are caused by a loss of neurons and glial cells in the brain or spinal cord. Cell replacement therapy and gene transfer to the diseased or injured brain have provided the basis for the development of potentially powerful new therapeutic strategies for a broad spectrum of human neurological diseases. However, the paucity of suitable cell types for cell replacement therapy in patients suffering from neurological disorders has hampered the development of this promising therapeutic approach. In recent years, neurons and glial cells have successfully been generated from stem cells such as embryonic stem cells, mesenchymal stem cells, and neural stem cells, and extensive efforts by investigators to develop stem cell‐based brain transplantation therapies have been carried out. We review here notable experimental and preclinical studies previously published involving stem cell‐based cell and gene therapies for Parkinson's disease, Huntington's disease, ALS, Alzheimer's disease, MS, stroke, spinal cord injury, brain tumor, and lysosomal storage diseases and discuss the future prospects for stem cell therapy of neurological disorders in the clinical setting. There are still many obstacles to be overcome before clinical application of cell therapy in neurological disease patients is adopted: 1) it is still uncertain what kind of stem cells would be an ideal source for cellular grafts, and 2) the mechanism by which transplantation of stem cells leads to an enhanced functional recovery and structural reorganization must to be better understood. Steady and solid progress in stem cell research in both basic and preclinical settings should support the hope for development of stem cell‐based cell therapies for neurological diseases. © 2009 Wiley‐Liss, Inc.
The effectiveness of implementing an electronic health record on diabetes care and outcomes.

OBJECTIVE To assess the impact of electronic health record (EHR) implementation on primary care diabetes care. DATA SOURCES Charts were abstracted semi-annually for 14,051 diabetes patients seen in 34 primary care practices in a large, fee-for-service network from January 1, 2005 to December 31, 2010. The study sample was limited to patients aged 40 years or older. STUDY DESIGN A naturalistic experiment in which GE Centricity Physician Office-EMR 2005 was rolled out over a staggered 3-year schedule. DATA COLLECTION Chart audits were conducted using the AMA/Physician Consortium Adult Diabetes Measure set. The primary outcome was the HealthPartners' "optimal care" measure: HbA1c ≤ 8 percent; LDL cholesterol < 100 mg/dl; blood pressure < 130/80 mmHg; not smoking; and documented aspirin use in patients ≥ 40 years of age. PRINCIPAL FINDINGS After adjusting for patient age, sex, and insulin use, patients exposed to the EHR were significantly more likely to receive "optimal care" when compared with unexposed patients (p < .001), with an estimated difference of 9.20 percent (95% CI: 6.08, 12.33) in the final year between exposed patients and patients never exposed. Components of the optimal care bundle showing positive improvement after adjustment were systolic blood pressure <80 mmHg, diastolic blood pressure <130 mmHg, aspirin prescription, and smoking cessation. Among patients exposed to EHR, all process and outcome measures except HbA1c and lipid control showed significant improvement. CONCLUSION Implementation of a commercially available EHR in primary care practice may improve diabetes care and clinical outcomes.
Air pollution and cause specific mortality in Athens.

STUDY OBJECTIVE--The aim was to investigate the reported association between air pollution and cause specific mortality in the city of Athens. DESIGN--Cause specific mortality was contrasted between 199 d with high values of air pollution and 2*199 comparison days with low pollution, matched in a 1:2 ratio on the basis of various confounding factors. Statistical analysis was done, taking matching into account, using analysis of variance for randomised blocks. SETTING--The study was confined to the city of Athens, using data obtained between 1975 and 1982. PARTICIPANTS--Cause of death was assessed in all 25 138 persons dying in the 3*199 d studied. MEASUREMENTS AND MAIN RESULTS--Causes of death were evaluated blindly by two medically qualified investigators on the basis of information in the death certificates. Mortality was generally higher during the high pollution days but the difference was more pronounced and more significant for respiratory conditions, even though the number of deaths in this category was smaller than the corresponding numbers in the other two categories examined (cardiac and "other" deaths). CONCLUSION--The results show that the short term association between air pollution and overall mortality in Athens is likely to be causal, since it is particularly evident with respect to respiratory conditions, for which a biological air pollution link is more plausible.