Miracle-dz/UniFAR-FTUs huggingface dataset:
Transcutaneous Immunization Using Colonization Factor and Heat-Labile Enterotoxin Induces Correlates of Protective Immunity for Enterotoxigenic Escherichia coli

ABSTRACT Enterotoxigenic Escherichia coli (ETEC) diarrheal disease is a worldwide problem that may be addressed by transcutaneous delivery of a vaccine. In several human settings, protective immunity has been associated with immune responses to E. coli colonization factors and to the heat-labile toxin that induces the diarrhea. In this set of animal studies, transcutaneous immunization (TCI) using recombinant colonization factor CS6 and cholera toxin (CT) or heat-labile enterotoxin (LT) as the adjuvant induced immunoglobulin G (IgG) and IgA anti-CS6 responses in sera and stools and antibody responses that recognized CS6 antigen in its native configuration. The antitoxin immunity induced by TCI was also shown to protect against enteric toxin challenge. Although immunization with LT via the skin induced mucosal secretory IgA responses to LT, protection could also be achieved by intravenous injection of the immune sera. Finally, a malaria vaccine antigen, merzoite surface protein 142 administered with CT as the adjuvant, induced both merzoite surface protein antibodies and T-cell responses while conferring protective antitoxin immunity, suggesting that both antiparasitic activity and antidiarrheal activity can be obtained with a single vaccine formulation. Overall, our results demonstrate that relevant colonization factor and antitoxin immunity can be induced by TCI and suggest that an ETEC traveler's diarrhea vaccine could be delivered by using a patch.
Slums from Space - 15 Years of Slum Mapping Using Remote Sensing

The body of scientific literature on slum mapping employing remote sensing methods has increased since the availability of more very-high-resolution (VHR) sensors. This improves the ability to produce information for pro-poor policy development and to build methods capable of supporting systematic global slum monitoring required for international policy development such as the Sustainable Development Goals. This review provides an overview of slum mapping-related remote sensing publications over the period of 2000–2015 regarding four dimensions: contextual factors, physical slum characteristics, data and requirements, and slum extraction methods. The review has shown the following results. First, our contextual knowledge on the diversity of slums across the globe is limited, and slum dynamics are not well captured. Second, a more systematic exploration of physical slum characteristics is required for the development of robust image-based proxies. Third, although the latest commercial sensor technologies provide image data of less than 0.5 m spatial resolution, thereby improving object recognition in slums, the complex and diverse morphology of slums makes extraction through standard methods difficult. Fourth, successful approaches show diversity in terms of extracted information levels (area or object based), implemented indicator sets (single or large sets) and methods employed (e.g., object-based image analysis (OBIA) or machine learning). In the context of a global slum inventory, texture-based methods show good robustness across cities and imagery. Machine-learning algorithms have the highest reported accuracies and allow working with large indicator sets in a computationally efficient manner, while the upscaling of pixel-level information requires further research. For local slum mapping, OBIA approaches show good capabilities of extracting both area- and object-based information. Ultimately, establishing a more systematic relationship between higher-level image elements and slum characteristics is essential to train algorithms able to analyze variations in slum morphologies to facilitate global slum monitoring.
Myocardial salvage by intravenous nitroglycerin in conscious dogs: loss of beneficial effect with marked nitroglycerin-induced hypotension.

We studied the effect of nitroglycerin-induced decreases in mean arterial pressure (MAP) on myocardial salvage. Two hours after occlusion of the left anterior descending coronary artery, 65 conscious dogs were randomly allocated to receive 4 hr intravenous infusions of saline (group 1, 19 dogs), or nitroglycerin in doses to decrease MAP by 10% (group 2, 18 dogs), 25% (group 3, 14 dogs), and 50% (group 4, 14 dogs), respectively. At 7 days, 41 dogs were killed for measurement of infarct size; 24 dogs, given 7 to 10 micron radioactive microspheres for flow calculations, were killed 6 hr after occlusion. Boundaries of the occluded bed were defined by postmortem coronary arteriography. Infarct and occluded bed masses were measured by planimetry of weighed transverse sections of the left ventricle. Compared with saline infusions in group 1, nitroglycerin infusions produced sustained reductions (p less than .001) in mean left atrial pressure and MAP in all dogs, but heart rate was unchanged. The decreases in MAP achieved in groups 2, 3, and 4 were 10% (range, 5% to 19%), 23%, and 39%, respectively, with average levels of 96 (range, 83 to 113), 83, and 64 mm Hg, respectively. Despite similar masses of the occluded bed and left ventricle among the four groups, infarct size was significantly smaller (p less than .025) in group 2 compared with groups 1, 3, or 4, expressed both as percent of the left ventricle (6% vs 14% vs 13% vs 15%) and as percent of the occluded bed (13% vs 37% vs 34% vs 44%). Myocardial salvage (expressed as percent of the occluded bed) with nitroglycerin correlated inversely with the percent of decrease in MAP (r = -.77, p less than .001). Collateral blood flow increased (p less than .005) throughout the occluded bed in group 2 compared with group 1 but was unchanged in groups 3 and 4. In contrast, coronary vascular resistance decreased (p less than .025) in all nitroglycerin groups. These results suggest that perfusion pressure is an important determinant of myocardial salvage during nitroglycerin therapy. An increase in the dose of nitroglycerin to decrease MAP by more than 10%, and to levels below 96 mm Hg, might offset its potential for myocardial salvage in the conscious dog.
Nanoparticles as Drug Delivery Systems in Cancer Medicine: Emphasis on RNAi-Containing Nanoliposomes

Nanomedicine is a growing research field dealing with the creation and manipulation of materials at a nanometer scale for the better treatment, diagnosis and imaging of diseases. In cancer medicine, the use of nanoparticles as drug delivery systems has advanced the bioavailability, in vivo stability, intestinal absorption, solubility, sustained and targeted delivery, and therapeutic effectiveness of several anticancer agents. The expansion of novel nanoparticles for drug delivery is an exciting and challenging research filed, in particular for the delivery of emerging cancer therapies, including small interference RNA (siRNA) and microRNA (miRNAs)-based molecules. In this review, we focus on the currently available drug delivery systems for anticancer agents. In addition, we will discuss the promising use of nanoparticles for novel cancer treatment strategies.
Selection of Suitable Features for Modeling the Durations of Syllables

Acoustic analysis and synthesis experiments have shown that duration and intonation patterns are the two most important prosodic features responsible for the quality of synthesized speech. In this paper a set of features are proposed which will influence the duration patterns of the sequence of the sound units. These features are derived from the results of the duration analysis. Duration analysis provides a rough estimate of features, which affect the duration patterns of the sequence of the sound units. But, the prediction of durations from these features using either linear models or with a fixed rulebase is not accurate. From the analysis it is observed that there exists a gross trend in durations of syllables with respect to syllable position in the phrase, syllable position in the word, word position in the phrase, syllable identity and the context of the syllable (preceding and the following syllables). These features can be further used to predict the durations of the syllables more accurately by exploring various nonlinear models. For analying the durations of sound units, broadcast news data in Telugu is used as the speech corpus. The prediction accuracy of the duration models developed using rulebases and neural networks is evaluated using the objective measures such as percentage of syllables predicted within the specified deviation, average prediction error (µ), standard deviation (σ) and correlation coefficient (γ).
Adaptive backstepping control for a class of uncertain MIMO systems with unknown control gain sign

In this paper an adaptive backstepping controller is proposed for a class of uncertain multi-input multi-output (MIMO) nonlinear systems. The system states are assumed to be immeasurable, so K-filters are employed as observers. Moreover, to relax the need for a priori knowledge of the control direction, Nussbaum-type technique is used. Neural networks are also employed to approximate the unknown nonlinearities in the system dynamics. The Lyapunov theorem is applied to prove that the overall closed loop control scheme is semi-globally uniformly ultimately bounded (SGUUB). Finally, the designed controller's performance is numerically examined against a two-link robot manipulator model.
Influence of sample shape and size on the shielding effectiveness of EMI when characterized with the stripline test method

This paper studies the influence of a gasket's shape and size on its high-frequency shielding-effectiveness as measured with the stripline test method. Based on full-wave simulations it is shown that the main influencing parameter for the shielding-effectiveness is the gasket's conductivity. Through a comparison with the reverberation room method, it is shown that differences due to shape and size of the gasket are not related to the stripline set-up, but are a reflection of the true shielding effectiveness of the gasket.
N-terminal and Central Segments of the Type 1 Ryanodine Receptor Mediate Its Interaction with FK506-binding Proteins*

Background: The 12-kDa binding protein for the immunosuppressant, FK506 (FKBP), modulates type 1 ryanodine receptor (RyR1) activity via unknown RyR1 sequence determinants. Results: Polyhistidine tags inserted in N-terminal and central RyR1 domains abolish FKBP binding, whereas high fluorescence resonance energy transfer is observed between FKBP and both domains. Conclusion: FKBP binds to determinants within both domains. Significance: Results support domain-switch malignant hyperthermia model. We used site-directed labeling of the type 1 ryanodine receptor (RyR1) and fluorescence resonance energy transfer (FRET) measurements to map RyR1 sequence elements forming the binding site of the 12-kDa binding protein for the immunosuppressant drug, FK506. This protein, FKBP12, promotes the RyR1 closed state, thereby inhibiting Ca2+ leakage in resting muscle. Although FKBP12 function is well established, its binding determinants within the RyR1 protein sequence remain unresolved. To identify these sequence determinants using FRET, we created five single-Cys FKBP variants labeled with Alexa Fluor 488 (denoted D-FKBP) and then targeted these D-FKBPs to full-length RyR1 constructs containing decahistidine (His10) “tags” placed within N-terminal (amino acid residues 76–619) or central (residues 2157–2777) regions of RyR1. The FRET acceptor Cy3NTA bound specifically and saturably to these His tags, allowing distance analysis of FRET measured from each D-FKBP variant to Cy3NTA bound to each His tag. Results indicate that D-FKBP binds proximal to both N-terminal and central domains of RyR1, thus suggesting that the FKBP binding site is composed of determinants from both regions. These findings further imply that the RyR1 N-terminal and central domains are proximal to one another, a core premise of the domain-switch hypothesis of RyR function. We observed FRET from GFP fused at position 620 within the N-terminal domain to central domain His-tagged sites, thus further supporting this hypothesis. Taken together, these results support the conclusion that N-terminal and central domain elements are closely apposed near the FKBP binding site within the RyR1 three-dimensional structure.
Patent based analysis of innovative rehabilitation technologies

Many factors point to the strategic role that can be played by technology information. Across a variety of institutions and fields of research, an increased sense of urgency to acquire useful knowledge has emerged. Patent information and relative analysis represent a wealth of information suitable to identify the state of the art of developments in specific technological fields. In this paper, a specific case study related to robotic and virtual systems for rehabilitation is analyzed and discussed. Data obtained from a patents database have been analyzed in order to better understand the interest and the evolution which characterize this specific sector, identifying applications and technologies.
Severe Exercise and Exercise Training Exert Opposite Effects on Human Neutrophil Apoptosis via Altering the Redox Status

Neutrophil spontaneous apoptosis, a process crucial for immune regulation, is mainly controlled by alterations in reactive oxygen species (ROS) and mitochondria integrity. Exercise has been proposed to be a physiological way to modulate immunity; while acute severe exercise (ASE) usually impedes immunity, chronic moderate exercise (CME) improves it. This study aimed to investigate whether and how ASE and CME oppositely regulate human neutrophil apoptosis. Thirteen sedentary young males underwent an initial ASE and were subsequently divided into exercise and control groups. The exercise group (n = 8) underwent 2 months of CME followed by 2 months of detraining. Additional ASE paradigms were performed at the end of each month. Neutrophils were isolated from blood specimens drawn at rest and immediately after each ASE for assaying neutrophil spontaneous apoptosis (annexin-V binding on the outer surface) along with redox-related parameters and mitochondria-related parameters. Our results showed that i) the initial ASE immediately increased the oxidative stress (cytosolic ROS and glutathione oxidation), and sequentially accelerated the reduction of mitochondrial membrane potential, the surface binding of annexin-V, and the generation of mitochondrial ROS; ii) CME upregulated glutathione level, retarded spontaneous apoptosis and delayed mitochondria deterioration; iii) most effects of CME were unchanged after detraining; and iv) CME blocked ASE effects and this capability remained intact even after detraining. Furthermore, the ASE effects on neutrophil spontaneous apoptosis were mimicked by adding exogenous H2O2, but not by suppressing mitochondrial membrane potential. In conclusion, while ASE induced an oxidative state and resulted in acceleration of human neutrophil apoptosis, CME delayed neutrophil apoptosis by maintaining a reduced state for long periods of time even after detraining.
Left-invariant extended Kalman filter and attitude estimation

We consider a left-invariant dynamics on a Lie group. One way to define driving and observation noises is to make them preserve the symmetries. We propose a left- invariant (i.e, intrinsic and thus symmetry-preserving) extended Kalman filter such that the left-invariant estimation error obeys a stochastic differential equation independent of the system trajectory. The theory is illustrated by an attitude estimation example.
Tactile Display of Vibratory Information in Teleoperation and Virtual Environments

This paper investigates the use of tactile displays for conveying task-related vibrations in teleoperation and virtual environments. Vibration displays can be implemented with inexpensive, open loop devices that can be added to many existing systems to improve performance. We describe the design of our prototype vibration sensing and display system, and experimentally demonstrate the utility of this type of tactile feedback. We also delineate the kinds of tasks where high-frequency vibratory feedback is important. In inspection and exploration tasks the detection of vibrations can be the fundamental goal of the task, while in some manipulation tasks vibrations can enhance performance by reducing reaction times or permitting minimization of ferees. Design guidelines for implementation of vibration displays, based on simple mechanical models, are also presented.
PENGEMBANGAN BAHAN AJAR BERBASIS MULTIMEDIA INTERAKTIFMATA KULIAH KOMPUTERISASI AKUNTANSI(STUDI KASUS : MYOB ACCOUNTING 17 PADA MODUL BANKING)

Dalam perkuliahan, proses pembelajaran menggunakan teknologi informasi dan komunikasi. Penggunaan tekhnologi informasi dan komunikasi dimaksudkan untuk membantu dosen dalam penyampaian materi dan juga membantu mahasiswa dalam memahami materi yang diajarkan. Selain itu muatan materi pelajaran dapat dimodifikasi menjadi lebih menarik dan mudah dipahami, tujuan materi yang sulit akan menjadi mudah, suasana belajar yang menegangkan menjadi menyenangkan. Dengan menggunakan TIK yang memadukan media-media dalam proses pembelajaran, maka proses pembelajaran akan berkembang dengan baik, sehingga membantu dosen menciptakan pola penyajian yang interaktif. Tujuan dari penelitian dan pengembangan bahan ajar ini adalah 1). Untuk mengembangkan Bahan Ajar Berbasis Multimedia Interaktif terhadap MYOB Accounting khususnya pada modul banking. 2). Untuk mengevaluasi efektivitas dan efisiensi penggunaan program bahan ajar berbasis multimedia interaktif MYOB dalam proses pembelajaran Mahasiswa Universitas Gunadarma Jurusan Akuntansi. Selain itu, dari penelitian yang telah dilakukan sebelumnya mengenai pengembangan teknologi informasi dan komunikasi untuk meningkatkan mutu pendidikan didapatkan hasil bahwa mahasiswa membutuhkan suatu bahan ajar lain yang dapat membantu proses belajar mahasiswa. Media pembelajaran ini berupa media berbasis TIK( Tekhnologi Informasi dan Komunikasi) seperti multimedia interaktif. Diharapkan dengan adanya website ini dapat memudahkan dan meningkatkan kualitas proses belajar mengajar serta memberikan kemudahan bagi dosen atau pengajar dan mahasiswa dalam melaksanakan kegiatan belajar mengajar.
Wrinkle Rendering of Terrain Models in Chinese Landscape Painting

Landscapes have been the main theme in Chinese painting for over one thousand years. Chinese ink painting is a form of non-photorealistic rendering. Terrain is the major subject in Chinese landscape painting, and surface wrinkles are important in conveying the orientation of mountains and contributing to the atmosphere. Over the centuries, masters of Chinese landscape painting have developed various kinds of wrinkles. This work develops a set of novel methods for rendering wrinkles in Chinese landscape painting. A three-dimensional terrain is drawn as an outline and wrinkles, using information on the shape, shade and orientation of the terrain's polygonal surface. The major contribution of this work lies in the modeling and implementation of six major types of wrinkles on the surface of terrain, using traditional Chinese brush techniques. Users can select a style of wrinkle and input parameters to control the desired effect. The proposed method then completes the painting process automatically.
Identifying fire plumes in the Arctic with tropospheric FTIR measurements and transport models

Abstract. We investigate Arctic tropospheric composition using ground-based Fourier transform infrared (FTIR) solar absorption spectra, recorded at the Polar Environment Atmospheric Research Laboratory (PEARL, Eureka, Nunavut, Canada, 80°05' N, 86°42' W) and at Thule (Greenland, 76°53' N, −68°74' W) from 2008 to 2012. The target species, carbon monoxide (CO), hydrogen cyanide (HCN), ethane (C2H6), acetylene (C2H2), formic acid (HCOOH), and formaldehyde (H2CO) are emitted by biomass burning and can be transported from mid-latitudes to the Arctic. By detecting simultaneous enhancements of three biomass burning tracers (HCN, CO, and C2H6), ten and eight fire events are identified at Eureka and Thule, respectively, within the 5-year FTIR time series. Analyses of Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) model back-trajectories coupled with Moderate Resolution Imaging Spectroradiometer (MODIS) fire hotspot data, Stochastic Time-Inverted Lagrangian Transport (STILT) model footprints, and Ozone Monitoring Instrument (OMI) UV aerosol index maps, are used to attribute burning source regions and travel time durations of the plumes. By taking into account the effect of aging of the smoke plumes, measured FTIR enhancement ratios were corrected to obtain emission ratios and equivalent emission factors. The means of emission factors for extratropical forest estimated with the two FTIR data sets are 0.40 ± 0.21 g kg−1 for HCN, 1.24 ± 0.71 g kg−1 for C2H6, 0.34 ± 0.21 g kg−1 for C2H2, and 2.92 ± 1.30 g kg−1 for HCOOH. The emission factor for CH3OH estimated at Eureka is 3.44 ± 1.68 g kg−1. To improve our knowledge concerning the dynamical and chemical processes associated with Arctic pollution from fires, the two sets of FTIR measurements were compared to the Model for OZone And Related chemical Tracers, version 4 (MOZART-4). Seasonal cycles and day-to-day variabilities were compared to assess the ability of the model to reproduce emissions from fires and their transport. Good agreement in winter confirms that transport is well implemented in the model. For C2H6, however, the lower wintertime concentration estimated by the model as compared to the FTIR observations highlights an underestimation of its emission. Results show that modeled and measured total columns are correlated (linear correlation coefficient r > 0.6 for all gases except for H2CO at Eureka and HCOOH at Thule), but suggest a general underestimation of the concentrations in the model for all seven tropospheric species in the high Arctic.
Perception of Affordances in Multi-Scale Dynamics as an Alternative Explanation for Equivalence of Analogical and Inferential Reasoning in Animals and Humans

Recent claims of equivalence of animal and human reasoning are evaluated and a study of avian cognition serves as an exemplar of weaknesses in these arguments. It is argued that current research into neurobiological cognition lacks theoretical breadth to substantiate comparative analyses of cognitive function. Evaluation of a greater range of theoretical explanations is needed to verify claims of equivalence in animal and human cognition. We conclude by exemplifying how the notion of affordances in multi-scale dynamics can capture behavior attributed to processes of analogical and inferential reasoning in animals and humans.