Miracle-dz/UniFAR-FTUs huggingface dataset:
Velocity changes, long runs, and reversals in the Chromatium minus swimming response

The velocity, run time, path curvature, and reorientation angle of Chromatium minus were measured as a function of light intensity, temperature, viscosity, osmotic pressure, and hydrogen sulfide concentration. C. minus changed both velocity and run time. Velocity decreased with increasing light intensity in sulfide-depleted cultures and increased in sulfide-replete cultures. The addition of sulfide to cultures grown at low light intensity (10 microeinsteins m-2 s-1) caused mean run times to increase from 10.5 to 20.6 s. The addition of sulfide to cultures grown at high light intensity (100 microeinsteins m-2 s-1) caused mean run times to decrease from 15.3 to 7.7 s. These changes were maintained for up to an hour and indicate that at least some members of the family Chromatiaceae simultaneously modulate velocity and turning frequency for extended periods as part of normal taxis.
Dynamic expression of neurotrophin receptors during sensory neuron genesis and differentiation.

To identify potential functions for neurotrophins during sensory neuron genesis and differentiation, we determined the temporal and spatial protein expression patterns of neurotrophin receptors throughout the process of sensory neurogenesis in the dorsal root ganglia (DRG). We show that neurotrophin receptors are expressed early, being first detected on subsets of migrating neural crest cells, and that trkC is among the earliest markers of neural lineage specification. In the immature DRG, we find that both trkC and p75(NTR) are expressed on subsets of dividing progenitor cells in vivo. Furthermore, our data directly reveal distinct patterns of trk receptor expression by individual sensory neurons from the time of their inception with all early arising cells initially being trkC(+), some subsets of whom also coexpress either trkA or trkB or both. As sensory neurons innervate their targets and establish their mature identities, the spectrum of trk receptors expressed by individual neurons is altered. The stereotyped trk receptor expression profiles identified here may potentially correspond to distinct lineages of sensory neurons. These data, in conjunction with other studies, argue for multiple functions for neurotrophins during the process of sensory neuron differentiation, including effects on both neural crest and DRG mitotically active progenitor cells, in addition to possibly influencing the establishment of sensory neuron identity.
Constructive Visualization: A New Paradigm to Empower People to Author Visualization

Introduction During the past two decades, information visualization (InfoVis) research has created new techniques and methods to support data-intensive analyses in science, industry and government. These have enabled a wide range of analysis tasks to be executed, which vary in terms of the type, and volume of data involved. However, the majority of this research has focused on static datasets, and the analysis and visualization tasks tend to be carried out by experts.
Improving Self-Heating Effect and Maximum Power Density in SOI MESFETs by Using the Hole’s Well Under Channel

In this brief, we present a new silicon-on-insulator MESFET by using an SiGe region as a well for absorbing the holes which are generated in result of the impact ionization mechanism. The key idea in this brief is to improve the breakdown voltage and self-heating effect (SHE) by utilizing an SiGe region to decreasing the crowding of holes around the source. The well is located in the buried oxide under the channel region. Simulation results show two extra peaks created on the electric field distribution that improves the breakdown voltage. Also, the floating body effect improves due to absorbing the holes by the hole's well and the lattice temperature decreases, so the SHE improves, too.
Novel targets for the future development of antibacterial agents

Recent advances in DNA sequencing technology have made it possible to elucidate the entire genomes of pathogenic bacteria, and advancements in bioinformatic tools have driven comparative studies of these genome sequences. These evaluations are dramatically increasing our ability to make valid considerations of the limitations and advantages of particular targets based on their predicted spectrum and selectivity. In addition, developments in gene knockout technologies amenable to pathogenic organisms have enabled new genes and gene products critical to bacterial growth and pathogenicity to be uncovered at an unprecedented rate. Specific target examples in the areas of cell wall biosynthesis, aromatic amino acid biosynthesis, cell division, two component signal transduction, fatty acid biosynthesis, isopreniod biosynthesis and tRNA synthetases illustrate how aspects of the above capabilities are impacting on the discovery and characterization of novel antibacterial targets. An example of a novel inhibitor of bacterial fatty acid biosynthesis discovered from high throughput screening processes is described, along with its subsequent chemical optimization. Furthermore, the application and importance of technologies for tracking the mode of antibacterial action of these novel inhibitors is discussed.
Reverse engineering camouflaged sequential circuits without scan access

Integrated circuit (IC) camouflaging is a promising technique to protect the design of a chip from reverse engineering. However, recent work has shown that even camouflaged ICs can be reverse engineered from the observed input/output behaviour of a chip using SAT solvers. However, these so-called SAT attacks have so far targeted only camouflaged combinational circuits. For camouflaged sequential circuits, the SAT attack requires that the internal state of the circuit is controllable and observable via the scan chain. It has been implicitly assumed that restricting scan chain access increases the security of camouflaged ICs from reverse engineering attacks. In this paper, we develop a new attack methodology to decamouflage sequential circuits without scan access. Our attack uses a model checker (a more powerful reasoning tool than a SAT solver) to find a discriminating set of input sequences, i.e., one that is sufficient to determine the functionality of camouflaged gates. We propose several refinements, including the use of a bounded model checker, and sufficient conditions for determining when a set of input sequences is discriminating to improve the run-time and scalabilty of our attack. Our attack is able to decamouflage a large sequential benchmark circuit that implements a subset of the VIPER processor.
Language-Agnostic Event Detection Across Sports from Twitter Using Temporal Features

A significant body of work focuses on detecting events in social media, much of which relies on restrictive assumptions like prior event-centric filtering or known language models. Rather than build these expensive pre-processing and filtering pipelines, we explore language-agnostic techniques using only temporal features like token frequency. We construct temporal features for tokens in an unfiltered Twitter stream, build a classifier to recognize tokens experiencing bursts in usage, and relate those bursts back to known occurrences within sports. Our results demonstrate preliminary feasibility in rapidly detecting tokens that correspond to highimpact occurrences within sporting events. We also successfully transfer a model trained on American football and hockey data to previously unseen types of sports like the 2014 World Cup and the 2014 Kentucky Derby/Belmont Stakes horse races. This model has less success at identifying events in regular-season Major League Baseball, so more research is required to enhance these capabilities.
Measuring through the microscope: Development and evolution of stereological methods

Obtaining, by means of microscopy, meaningful measurements pertaining to spatial structures requires methods which allow three‐dimensional quantitative information to be derived from the reduced information available on the two‐dimensional flat sections of the structure. The most powerful methods to that effect are those of stereology which are based on mathematical principles. This paper reviews the early invention of these methods, which sought to solve practical problems, and their further evolution as more rigorous mathematical foundations were developed. It is demonstrated that stereological methods are essentially sampling methods and that newer trends provide new and sound solutions to old and elusive problems, such as anisotropy or particle number and size.
Haksoon Kim Does Corporate Governance or Transparency Affect Foreign Direct Investment ?

The paper investigates the relationship between the foreign direct investment (FDI) and the corporate governance or transparency by investigating the country-level FDI flows, FDI inward performance, corporate governance and transparency variables. From the regression analysis with Newey-West estimator of 28 country panel data from 19902002, we find strong positive relationships between corporate governance or transparency level of hosting countries and FDI inward performance within hosting countries. A strong positive relationship is found between anti-director rights level or number of analysts of hosting countries and FDI inward performance within hosting countries. Also, we find a positive relationship between the number of analysts of hosting countries and FDI inflows. The empirical results are consistent with stock market liberalizations and corporate governance explanations of reasons for FDI. Keywords—corporate governance, corporate transparency, FDI flows, FDI inward performance
Hypermutability and error catastrophe due to defects in ribonucleotide reductase

Significance The accuracy by which cells are able to replicate their chromosomal DNA is critical for the rate by which they produce mutations. To keep the mutation rate low, cells have developed several mechanisms including accurate base selection by DNA polymerase, exonucleolytic proofreading that can excise incorrectly inserted bases, and postreplicative DNA mismatch repair. Also important are the concentrations of the deoxynucleoside-5′-triphosphates (dNTPs) that serve as direct substrates for the DNA synthesis reaction. Here, we describe a case in which certain changes in the relative levels of the four dNTPs (dATP, dTTP, dGTP, dCTP) can profoundly disturb the overall replication fidelity by impairing the efficiency of each of the three main fidelity systems, leading to a case of extreme hypermutability. The enzyme ribonucleotide reductase (RNR) plays a critical role in the production of deoxynucleoside-5′-triphosphates (dNTPs), the building blocks for DNA synthesis and replication. The levels of the cellular dNTPs are tightly controlled, in large part through allosteric control of RNR. One important reason for controlling the dNTPs relates to their ability to affect the fidelity of DNA replication and, hence, the cellular mutation rate. We have previously isolated a set of mutants of Escherichia coli RNR that are characterized by altered dNTP pools and increased mutation rates (mutator mutants). Here, we show that one particular set of RNR mutants, carrying alterations at the enzyme's allosteric specificity site, is characterized by relatively modest dNTP pool deviations but exceptionally strong mutator phenotypes, when measured in a mutational forward assay (>1,000-fold increases). We provide evidence indicating that this high mutability is due to a saturation of the DNA mismatch repair system, leading to hypermutability and error catastrophe. The results indicate that, surprisingly, even modest deviations of the cellular dNTP pools, particularly when the pool deviations promote particular types of replication errors, can have dramatic consequences for mutation rates.
IMPROVING THE CLASSIFICATION ACCURACY USING SUPPORT VECTOR MACHINES (SVMS) WITH NEW KERNEL

In this paper, we introduce a new kernel function called polynomial radial basis function (PRBF) that could improve the classification accuracy of support vector machines (SVMs). The proposed kernel function combines both Gauss (RBF) and Polynomial (POLY) kernels and is stated in general form. It is shown that the proposed kernel converges faster than the Gauss and Polynomial kernels. The accuracy of the proposed algorithm is compared to algorithms based on both Gaussian and polynomial kernels by application to a variety of non-separable data sets with several attributes. We noted that the proposed kernel gives good classification accuracy in nearly all the data sets, especially those of high dimensions.
Founder mutation in the BRCA1 gene in Malay breast cancer patients from Singapore

The mutation spectrum of the BRCA1 gene among ethnic groups from Asia has not been well studied. We investigated the frequency of mutations in the BRCA1 gene among Malay breast cancer patients from Singapore, independent of family history. By using the protein truncation test (PTT) and direct sequencing, BRCA1 mutations were detected in 6 of 49 (12.2%) unrelated patients. Four novel missense mutations in exon 11, T557A (1788A>G), T582A (1863A>G), N656S (2086A>G) and P684S (2169C>T) were identified in one patient. Two patients had missense mutations in exon 23, V1809A (5545T>C), which has been previously detected in individuals from Central and Eastern Europe. Three unrelated patients had the deleterious 2846insA frameshift mutation in exon 11. Methylation specific PCR (MSP) of the promoter region of the BRCA1 gene detected hypermethylation of tumor DNA in an additional 2 patients. Haplotype analysis using the microsatellite markers D17S855, D17S1323 and D17S1325 revealed a common haplotype for the three unrelated patients and their three relatives with the 2846insA mutation. These findings strongly suggest that the 2846insA mutation, the most common deleterious mutation in this study, may possibly be a founder mutation in breast cancer patients of Malay ethnic background. © 2003 Wiley‐Liss, Inc.
Intestinal Behçet syndrome: CT features of patients with and patients without complications.

PURPOSE To analyze the computed tomographic (CT) features of intestinal Behçet syndrome and to determine the usefulness of CT in detecting complications. MATERIALS AND METHODS The CT scans of 28 patients with intestinal Behçet syndrome were retrospectively reviewed. Five patients had bowel perforation, and two had peritonitis. Patterns of bowel involvement, patterns of contrast enhancement, and ancillary findings were compared in patients with complications (n = 7) and patients without complications (n = 21). RESULTS Ten patients had polypoid lesions, nine had a thickened bowel wall, and nine had both findings. Lesion enhancement was mild in eight patients (29%) and marked in 20 (71%). Polypoid lesions were more commonly seen in patients without complications (P = .020); a thickened bowel wall was more commonly seen in patients with complications (P = .030). Seventeen of 18 patients (94%) with minimal perienteric infiltration did not have complications (P = .0003), whereas all five patients with severe perienteric infiltration did have complications. CONCLUSION In patients with known intestinal Behçet syndrome, CT can be useful in determining the extent of the lesions and in identifying cases in which complications are likely to occur.
Helicobacter pylori Initiates the Stringent Response upon Nutrient and pH Downshift

ABSTRACT Helicobacter pylori was previously reported to lack a stringent response. In contrast, we show that after nutrient downshift, H. pylori produced abundant ppGpp and less total RNA. pH downshift also caused (p)ppGpp accumulation. Our observations indicate that nutrient deprivation and acid shock activate the stringent response in H. pylori.
Effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction: a systematic review and meta-analysis of randomized controlled trials

Background: Evidence from controlled trials encourages the intake of dietary pulses (beans, chickpeas, lentils and peas) as a method of improving dyslipidemia, but heart health guidelines have stopped short of ascribing specific benefits to this type of intervention or have graded the beneficial evidence as low. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction. Methods: We searched electronic databases and bibliographies of selected trials for relevant articles published through Feb. 5, 2014. We included RCTs of at least 3 weeks’ duration that compared a diet emphasizing dietary pulse intake with an isocaloric diet that did not include dietary pulses. The lipid targets investigated were low-density lipoprotein (LDL) cholesterol, apolipoprotein B and non–high-density lipoprotein (non-HDL) cholesterol. We pooled data using a random-effects model. Results: We identified 26 RCTs (n = 1037) that satisfied the inclusion criteria. Diets emphasizing dietary pulse intake at a median dose of 130 g/d (about 1 serving daily) significantly lowered LDL cholesterol levels compared with the control diets (mean difference −0.17 mmol/L, 95% confidence interval −0.25 to −0.09 mmol/L). Treatment effects on apolipoprotein B and non-HDL cholesterol were not observed. Interpretation: Our findings suggest that dietary pulse intake significantly reduces LDL cholesterol levels. Trials of longer duration and higher quality are needed to verify these results. Trial registration: ClinicalTrials.gov, no. NCT01594567.
Research on terminal guidance of SUAV based on strapdown image module

A terminal guidance control method based on strapdown image is proposed and implemented on a SUAV (Small Unmanned Aerial Vehicle) equipped with a strapdown image processing module and a redeveloped commercial autopilot. When compared to image stabilization platform, strapdown image module which includes a highly integrated image processing board and a micro electro-optic camera is significantly smaller, lighter and less costly. We measure the vertical line-of-sight angle 0c and the horizontal line-of-sight angle θc as angles of deviation and actually do an angle tracking. Besides, Median-Flow tracking algorithm which is good at tracking a stationary target with obvious features and a designed terminal guidance controller on the basis of STT are adopted. This method is tested and verified repeatedly by using a commercial foam aircraft on spot landing and SUAV recycling. The performance is beyond expectation with a relatively high precision.
Physical Analysis of Autographa californica Nuclear Polyhedrosis Virus Transcripts for Polyhedrin and 10,000-Molecular-Weight Protein

In Autographa californica nuclear polyhedrosis virus-infected cells, polyhedrin, the major structural polypeptide of the viral occlusions, and a low-molecular-weight viral protein with a molecular weight of approximately 10,000 (10K) accumulated to high levels late in infection. Two polyadenylated RNAs 1,200 and 630 bases in size were the most abundant viral transcripts present in the cytoplasm at 48 h postinfection. Evidence is presented that these RNAs were the transcripts for polyhedrin and 10K proteins. The 630-base RNA and five other major polyadenylated RNAs present at 48 h postinfection mapped within or near A. californica nuclear polyhedrosis virus EcoRI-P. The DNA sequences that code for polyhedrin mRNA were examined by S1 nuclease analysis. The polyhedrin gene contained no detectable introns and mapped at 3,990 to 5,200 base pairs to the right of the origin of the circular A. californica nuclear polyhedrosis virus physical map. Heterogeneity at the 5′ end of polyhedrin mRNA was observed by using S1 nuclease analysis with 5′ end-labeled DNA probes.
GPS-based message broadcasting for inter-vehicle communication

Intelligent Transportation Systems (ITS) have become a focus for many countries. To achieve ITS, Inter Vehicle Communication (IVC) is required for the exchange and distribution of data such as congestion or emergency information. If this communication can be done without fixed infrastructure, the systems can be deployed quickly and on a larger scale. Ad hoc networking technologies are one such technology to achieve IVC. However, if generic ad hoc network solutions are applied directly to IVC, performance can degrade quickly as the system scales particularly for broadcast type messages. In this paper we propose two new broadcast protocols that reduce bandwidth required for broadcast communication by taking advantage of a vehicle's highly directional movement and Global Positioning Information. To show the performance of our new protocols, we compare our approach with generic ad hoc broadcasting techniques. Our results show that it is possible to achieve several hundred percent improvement of bandwidth utilization with very slight sacrifice of reachability.
Repair of congenital tracheal stenosis.

We have used six different techniques in 61 operations performed at Children's Memorial Hospital (Chicago, IL) between 1982 and 2001 on 54 infants with complete tracheal rings and primary or recurrent tracheal stenosis. Short-term and long-term outcomes are reviewed for all techniques including pericardial tracheoplasty, tracheal autograft, tracheal resection, cartilage tracheoplasty, slide tracheoplasty, and aortic homograft patch tracheoplasty. Patients' ages ranged from 7 days to 72 months; mean age at operation was 6 months. There were 33 boys and 21 girls. Associated pulmonary artery sling was present in 19 of 54 patients (35%). Significant associated intracardiac anomaly was present in 13 of 54 patients (24%). The number of complete tracheal rings involved ranged from two to 18 rings (mean, 14+/-5). All procedures were performed with the use of cardiopulmonary bypass. Simultaneous repair of pulmonary artery sling and cardiac abnormalities was undertaken. There were three early deaths, two after pericardial tracheoplasty and one after tracheal autograft. There were eight late deaths, five after pericardial tracheoplasty, one after tracheal autograft, one after slide tracheoplasty, and one after tracheal resection. Median length of hospital stay was 60 days for pericardial tracheoplasty, 28 days for tracheal autograft, 14 days for tracheal resection, and 18 days for the slide tracheoplasty. Follow-up is complete in all patients. Tracheal autograft is currently our procedure of choice for patients with long-segment tracheal stenosis because of its use of all-autologous material, technical ease of performance, already-present epithelial lining of the autograft, intrinsic maintenance of the cartilage contour, potential for growth, and ready availability. We limit the use of tracheal resections to patients with eight or less rings of tracheal stenosis.