Miracle-dz/UniFAR-FTUs huggingface dataset:
Induction of the adaptive response by X-rays is dependent on radiation intensity.

Human lymphocytes pretreated with low (0.01 Gy) but not high (0.5 Gy) doses of X-rays become somewhat refractory to the induction of chromatid deletions by subsequent exposure to high (1.5 Gy) doses of X-rays (i.e. the yield of chromatid deletions is less than the sum of the yields induced by the pre-exposure and the subsequent challenge doses). This adaptive response can also be induced by pretreating the cells with very low, or even high, concentrations of tritiated thymidine. Because high concentrations of tritiated thymidine result in high doses of radiation that are delivered at very low dose-rates (i.e. less than 0.01 Gy/min), the lack of adaptation following high pre-treatment doses of X-rays could be attributed to their higher dose-rates. To test the effect of X-ray intensity on the induction of the adaptive response, lymphocytes were irradiated with 0.5 Gy of X-rays at 0.005-0.5 Gy/min at 28-30 h of culture, and then irradiated with 1.5 Gy at 48 h. Chromatid deletions were measured 6 h later. The results show that 0.5 Gy of X-rays given at low dose-rates (0.005 or 0.01 Gy/min), but not at high dose-rates (0.1, 0.2, or 0.5 Gy/min), are capable of inducing the adaptive response. Furthermore, experiments in which a male subject's cells exposed to 0.5 Gy given at 0.005 Gy/min were cocultivated with a female subject's cells irradiated with 0.5 Gy at 0.5 Gy/min showed that cells exposed to radiation at low and high intensity progress to metaphase equally and, therefore, that the lack of an adaptive response at high dose-rates cannot be attributed to selection of radioresistant cells. Although the induction of the adaptive response at higher X-ray doses occurs at low radiation intensity, there seems to be a minimum dose required for this effect; e.g., 0.01-Gy pretreatments induced the adaptive response when given at 0.2 Gy/min, but not at 0.005 Gy/min. Thus, the adaptive response is dependent both on the total dose of the pretreatment and on the rate at which the dose is given.
THE RELATIONSHIP OF ANTHROPOMETRY AND BODY COMPOSITION WITH RUNNING ECONOMY

The aim of this study was to investigate the relationships of anthropometry and body composition with running economy within a large heterogeneous cohort of runners. Locomotory energy cost was determined in ninety-four healthy male and female endurance runners across a range of performance standards. Various anthropometric and body composition measurements were taken manually and via DXA scans. The relationships between anthropometry and running economy were assessed using independent Pearson’s correlation and stepwise multiple linear regression. Three parameters, normalised neck and calf perimeters and normalised whole body bone mass explained 30% of the variance in locomotory energy cost. Low locomotory energy cost was related solely to parameters indicating relative slenderness of the body.
The Divide: A Brief Guide to Global Inequality and its Solutions

For decades we have been told a story about the divide between rich countries and poor countries. We have been told that development is working: that the global South is catching up to the North, that poverty has been cut in half over the past thirty years, and will be eradicated by 2030. It’s a comforting tale, and one that is endorsed by the world’s most powerful governments and corporations. But is it true? Since 1960, the income gap between the North and South has roughly tripled in size. Today 4.3 billion people, 60 per cent of the world's population, live on less than $5 per day. Some 1 billion live on less than $1 a day. The richest eight people now control the same amount of wealth as the poorest half of the world combined. What is causing this growing divide? We are told that poverty is a natural phenomenon that can be fixed with aid. But in reality it is a political problem: poverty doesn’t just exist, it has been created. Poor countries are poor because they are integrated into the global economic system on unequal terms. Aid only works to hide the deep patterns of wealth extraction that cause poverty and inequality in the first place: rigged trade deals, tax evasion, land grabs and the costs associated with climate change. The Divide tracks the evolution of this system, from the expeditions of Christopher Columbus in the 1490s to the international debt regime, which has allowed a handful of rich countries to effectively control economic policies in the rest of the world. Because poverty is a political problem, it requires political solutions. The Divide offers a range of revelatory answers, but also explains that something much more radical is needed – a revolution in our way of thinking. Drawing on pioneering research, detailed analysis and years of first-hand experience, The Divide is a provocative, urgent and ultimately uplifting account of how the world works, and how it can change.
Introduction: The multiple challenges and layers of water justice struggles

Introduction Water is a resource that triggers profound conflicts and close collaboration, a source of deep injustices, and fierce struggles for life. In many regions of the world, rising demand and declining availability of adequate-quality water foster severe competition and ferocious clashes among different water uses and users. People also suffer from flooding; contamination caused by industry and mining; privatization of public water utilities; corruption; and displacement by large dam projects. Climate change intensifies most human-made water problems. In struggles for water security, the poor tend to lose (e.g. Crow et al., 2014; Escobar, 2006; Harvey, 1996; Perreault et al., 2011). Through exemplary cases, the chapters in this book show how new competitors - including megacities, mining, forestry, and agribusiness companies - demand and usurp a mounting share of available surface and groundwater resources (e.g., Donahue and Johnston, 1998; GRAIN, 2012). Water deprivation and water insecurity affect marginalized urban households, and rural smallholder families and communities. In many regions, this poses profound threats to environmental sustainability and local and national food security (e.g., Escobar, 2008; Mehta et al., 2012; Mena et al., 2016). Such proliferating problems of material and social “water injustices” provide the backdrop for this book. Distribution of access water rights and water-related decision-making is extremely skewed. Smallholder communities’ water-based livelihoods and rights in many countries of the global South are constantly threatened by bureaucratic administrations, market-driven policies, and top-down project intervention practices. Despite the fact that water injustices have existed throughout human history, water justice problems and related policy interventions have changed rapidly over recent decades (Zwarteveen and Boelens, 2014). For instance, rather than focusing on simply enlarging water flows through new hydraulic engineering projects, new perspectives focus on water saving and conservation (Vos and Marshall, 2017; Zwarteveen, 2015). New scientific fields and water professionals have entered the water policy-making and intervention worlds to accompany (increasingly high-tech) hydraulic engineering (Buscher and Fletcher, 2015; Goldman, 2007, 2011). Also, climate change threats and water-related disasters have changed science and policy debates and water funding projects related to issues such as “mitigation and adaptation,” flood control and drought prevention (Heynen et al., 2007; Lynch, 2012; Martinez-Alier, 2002). Further, global neoliberalism has assured that water development and governance are no longer seen as the exclusive realm of the state, with water knowledge and authority concentrated in powerful public agencies (Hommes et al., 2016; Loftus, 2009; Zwarteveen, 2015).
Football and Sustainability in the Desert, Qatar 2022 Green World Cup's Stadiums: Legal Perspective

As the year 2022 approaching, Qatar preparations for the FIFA World Cup is in progress. These preparations encompass very complicated processes in many and almost every aspect of life in the state of Qatar. Qatar promised the world with unprecedented, unforgettable, and magical tournament in the history. In this complicated process, environment is not irrelevant, rather, it is presented and taken into consideration, it is the promise of the State of Qatar to organize environment friendly World Cup. Environmental and sustainability requirements are considered and monitored by Qatar’s legal and administrative frameworks, these requirements are to be observed during preparation and implementation processes and finally in the realization and organization of the tournament. From a legal and environmental perspective, this paper will explore the presence of the environment and sustainability in the Qatar 2022 bid, preparations, management, and delivery of the Stadiums constructed for the FIFA World Cup Qatar 2022.
Regulation of connexin 43 gene expression by cyclical mechanical stretch in neonatal rat cardiomyocytes.

Myocardial cells respond to changes in the mechanical forces imposed on them with changes in myocardial tension in the short term and with structural remodeling in the long term. Since these responses involve intercellular communication, we have investigated regulation of the gap junction proteins, connexin 43 (Cx43), connexin 40 (Cx40) and connexin 37 (Cx37), by cyclical mechanical stretch. Results were compared with parallel experiments on c-fos and GAPDH. Twenty percent stretch of cultured rat cardiomyocytes caused a 3-fold increase in Cx43 mRNA levels by 2 h. c-fos mRNA levels increased after 30 min of stretch, whereas Cx40, Cx37, and GADPH mRNA did not change. Protein levels of Cx43 increased by 4 h and remained elevated for 16 h. New protein synthesis was not a requirement for the stretch-induced rise in Cx43 expression, since mRNA levels were unaffected by treatment with cycloheximide. In addition, mechanical stretch induced alkalization of cardiomyocytes that was antagonized by inhibiting Na-H exchanger (NHE). Gap junction potential (Gj) was concomitantly elevated. Chemical closure of Cx channels by insulin was followed by inhibition of NHE. In conclusion, cyclical mechanical stretch caused increased expression of the gap junction protein Cx43 in cardiomyocytes and also the Gj. The augmentation of Cx43 mRNA expression and its functional status were associated with activation of NHE.
On the relation between analysis and synthesis conditions for discrete-time systems with saturation nonlinearities

This paper considers linear time-invariant (LTI) discrete-time systems with saturation and/or dead-zone nonlinearities, and proposes analysis and synthesis methods of a regional l2performance and/or a pole placement based on a quadratic Lyapunov function via a generalized sector and a polytopic approach. In particular, a new domain of l2performance is defined by a region of initial states of the system considering the l2performance and/or the pole placement. For analysis, the problems based on the two approaches can be recast as linear matrix inequality (LMI) optimization ones respectively, and in the special case of single saturation or single dead-zone nonlinearity, it is proved that the generalized sector approach is exactly the same as the polytopic approach. Similarly, for synthesis, the problem based on the generalized sector approach can be recast as an LMI optimization problem where the outputs of the nonlinearities are assumed to be available for control. Next, the relation is clarified that the analysis and synthesis conditions can be reduced to the corresponding conditions for the continuous-time systems as the sampling period goes to zero. Finally, it is pointed out that our LMI-based approach is helpful through a numerical example designing anti-windup control systems.
Need Analysis Mapping of Entrepreneurship Training of University Student

The purposes of this research are: (1) describing the need of entrepreneurship training of university student, and (2) understanding the different need of entrepreneurship training of university students based on their sexes. This research uses quantitative approach with comparative descriptive design. The objects of research are students from Department of Educational Administration, State University of Malang, 2013 and 2014 generation. The results are as follows: (1) almost a half of respondents has entrepreneurship experience and idea which is dominated by fashion and culinary sector; and (2) there are some steps in conducting entrepreneurship training of university students, including: planning (need analysis), implementation, evaluation. The expected output and outcome are that the students are able to settle business. Each step has certain criteria. There are not any differences on the need of joining entrepreneurship training for university students.
Validity of the Brief Pain Inventory for Use in Documenting the Outcomes of Patients With Noncancer Pain

Objectives:The Brief Pain Inventory (BPI) is a short, self-administered questionnaire that was developed for use in cancer patients. While most empirical research with the BPI has been in pain of that etiology, the questionnaire is increasingly evident in published studies of patients with non-cancer pain. The current research addresses the need for formal evaluation of the reliability and validity of the BPI for use in non-cancer pain patients. Methods:Approximately 250 patients with arthritis or low back pain (LBP) self-administered a number of generic and condition-specific health status measures (including the BPI) in the clinic of their primary care provider at 2 time points: the initial clinic visit and the first visit following treatment. Results:The reliability of BPI data collected from non-cancer pain patients was comparable to that reported in the literature for cancer patients and sufficient for group-level analyses (coefficient alphas were greater than 0.70). The factor structure of the BPI was replicated in this sample and the relationship of the BPI to generic measures of pain was strong. The BPI exhibited similar relationships to general and condition-specific measures of health as did a generic pain scale (SF-36 Bodily Pain). Finally, the BPI discriminated among levels of condition severity and was sensitive to change in condition over time in arthritis and LBP patients. Discussion:Results support the validity of the BPI as a measure of pain in patients without cancer and, in particular, as a measure of pain for arthritis and LBP patients.
Neuronal nitric oxide synthase-immunoreactivity. A neuromodulating system independent of peripheral nasal gland denervation in guinea pig nasal mucosal tissue after treatment with botulinum toxin type A.

The influence of botulinum toxin type A (BTA) on cellular mechanisms has not been studied in much detail. Since nitric oxide (NO) is of increasing interest as a neuromodulator in the innervation of the nose, its localization was examined in the nasal mucosa of guinea pigs treated with BTA or saline. Neuronal nitric oxide synthase-immunoreactivity (nNOS-IR) was found around vessels and nasal glands. Immunoreactivity was seen in the respiratory epithelium, in the periost and the osteocytes of the turbinate bone. A distinct interindividual difference in the strength of nNOS-IR was obvious among the animals, but there was no difference in the strength of immunoreactivity between the animals treated with BTA or saline. NO might therefore contribute to the regulation of vascular tone, glandular function, respiratory epithelial cell function and bone metabolism. BTA does not seem to influence the processes regulated and modulated by NO. This may represent a benefit for the application of BTA.
Integrating QFD for product-service systems with the Kano model and fuzzy AHP

The paper proposes a systematic procedure for the development of Product-Service Systems (PSSs) by focusing on the analysis of customer requirements, and the selection of those that can practically enhance the offerings’ value. With this goal in mind, the Quality Function Deployment for Product Service Systems (QFDforPSS) method was augmented by means of the Kano model to filter the customers’ needs and transform the attractive ones into Receiver State Parameters (RSPs), as the cornerstone of QFDforPSS. Then, to properly assess these parameters and their inherent uncertainty, the Fuzzy Analytical Hierarchy Process (FAHP) method was also integrated into the procedure. To validate the proposed procedure, it was implemented in a case study in the medical devices sector, in collaboration with a haemodialysis equipment manufacturer, which operates in a regulated market of product-oriented services.
Improved high-k/metal gate lifetime via improved SILC understanding and mitigation

For the first time, we identify key factors impacting SILC through a comprehensive reliability study for high-k/metal gate nMOSFET with several mitigating process changes. SILC is increasingly important because higher SILC can distort time-dependent dielectric breakdown (TDDB) lifetime extraction. We find that high-k bulk layer and interfacial layer both contribute to SILC characteristics. We propose a direction to SILC reduction, thereby improving device lifetime.
Long-term outcome of open or endovascular repair of abdominal aortic aneurysm.

BACKGROUND For patients with large abdominal aortic aneurysms, randomized trials have shown an initial overall survival benefit for elective endovascular repair over conventional open repair. This survival difference, however, was no longer significant in the second year after the procedure. Information regarding the comparative outcome more than 2 years after surgery is important for clinical decision making. METHODS We conducted a long-term, multicenter, randomized, controlled trial comparing open repair with endovascular repair in 351 patients with an abdominal aortic aneurysm of at least 5 cm in diameter who were considered suitable candidates for both techniques. The primary outcomes were rates of death from any cause and reintervention. Survival was calculated with the use of Kaplan-Meier methods on an intention-to-treat basis. RESULTS We randomly assigned 178 patients to undergo open repair and 173 to undergo endovascular repair. Six years after randomization, the cumulative survival rates were 69.9% for open repair and 68.9% for endovascular repair (difference, 1.0 percentage point; 95% confidence interval [CI], -8.8 to 10.8; P=0.97). The cumulative rates of freedom from secondary interventions were 81.9% for open repair and 70.4% for endovascular repair (difference, 11.5 percentage points; 95% CI, 2.0 to 21.0; P=0.03). CONCLUSIONS Six years after randomization, endovascular and open repair of abdominal aortic aneurysm resulted in similar rates of survival. The rate of secondary interventions was significantly higher for endovascular repair. (ClinicalTrials.gov number, NCT00421330.)
Thermal stability of proteins in the presence of aprotic ionic liquids

Thermal stability of lysozyme dissolved in aqueous solutions was examined in the presence of water-miscible aprotic ionic liquids consisting of 1-ethyl-3-methylimidazolium cation and several kinds of anions. Addition of ionic liquids to an aqueous solution containing lysozyme prevented unfolded proteins from aggregating irreversibly at high temperatures. The thermal denaturation curve of lysozyme with ionic liquids was entirely shifted to higher temperature, compared with that without ionic liquids. The remaining activity of lysozyme after the heat treatment was markedly dependent upon the kind and concentration of ionic liquids. The remaining activi-ties of lysozyme with 1.5 M 1-ethyl-3-methylimida-zolium tetrafluoroborate ([emim][BF4]) and 0.1 M 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([emim][Tf]) exhibited 88 and 68% after the heat treatment at 90oC for 30 min, respectively, although that without ionic liquids was perfectly lost.
Biodistribution and blood metabolism of 1-11C-methyl-4-piperidinyl n-butyrate in humans: an imaging agent for in vivo assessment of butyrylcholinesterase activity with PET.

UNLABELLED 1-(11)C-Methyl-4-piperidinyl n-butyrate ((11)C-MP4B) is a new radiopharmaceutical for the in vivo assessment of butyrylcholinesterase (BuChE) activity using PET. To quantify in vivo activity of BuChE with a kinetic model, investigators must determine the time course of radioactivity associated with unchanged (11)C-MP4B. We aimed at clarifying the metabolic fate and whole-body distribution of intravenously administered (11)C-MP4B in man. METHODS High-performance liquid chromatography and thin-layer chromatography assays were performed to determine the amounts of intact (11)C-MP4B and its radioactive hydrolysis product in blood withdrawn during PET. In addition, we evaluated the distribution and kinetics of (11)C-MP4B uptake in human brain and main organs. RESULTS The analysis of plasma samples of 28 human subjects (10 patients with Alzheimer's disease [AD] and 18 healthy controls) showed that the level of unmetabolized (11)C-MP4B decreases rapidly from 28% +/- 14% (mean +/- SD) at 0.5 min to 7% +/- 6% at 15 min after injection. Large individual variation was observed in the rate of plasma (11)C-MP4B hydrolysis, but no significant differences were found in the degradation of (11)C-MP4B either between male and female or between healthy subjects and patients. The whole-body distribution of (11)C-MP4B showed the highest activities in the urinary bladder, renal pelvis, stomach, salivary glands, liver, kidneys, spleen, vertebral column, and brain. In patients with AD, (11)C-MP4B activity in the brain was highest in cerebellum, followed by striatum, pons, and thalamus. Lower (11)C-MP4B activity was seen in cortical areas. CONCLUSION Our results indicate that (11)C-MP4B is excreted rapidly through the renal system. Careful analysis of plasma metabolites is required to determine the accurate arterial input function for quantitative PET measurement. Biodistribution of (11)C-MP4B in the brains of patients with AD appears to be in accordance with the distribution of BuChE seen in postmortem studies of human brain, except for the observed higher activity in striatum than in cortex. Further studies of the cerebral distribution and regional kinetic analysis of (11)C-MP4B are in progress.
Generic Centralized Downlink Scheduler for Next Generation Wireless Cellular Networks

Future wireless cellular networks such as high speed downlink packet access (HSDPA) and 1x EVolution data optimized (1xEV-DO) promise to revolutionize the mobile user's wireless experience by offering high downlink data rates that are much more beyond what 2.5 G and 3 G cellular systems could offer. In order to support as many users as possible, these systems exploit the bursty nature of the data traffic by utilizing high speed downlink shared channels that are shared among the users according to the packet scheduling scheme being used. However, to support acceptable performance levels especially at peak loads, these systems require much more efficient downlink packet scheduling schemes than ever before. In this paper, we propose a novel generic centralized downlink (GCD) packet scheduling scheme for next generation wireless cellular networks. The proposed scheme utilizes novel utility and opportunity cost functions to satisfy the mobile users as well as the service providers. We show that our scheme converges to two well known schemes, Max CIR and PF. Simulation results are provided to show the effectiveness and strength of the GCD scheme.