Miracle-dz/UniFAR-FTUs huggingface dataset:
Ensuring the Stability of the Genome: DNA Damage Checkpoints

The cellular response to DNA damage is vital for the cell's ability to maintain genomic integrity. Checkpoint signalling pathways, which induce a cell cycle arrest in response to DNA damage, are an essential component of this process. This is reflected by the functional conservation of these pathways in all eukaryotes from yeast to mammalian cells. This review will examine the cellular response to DNA damage throughout the cell cycle. A key component of the DNA damage response is checkpoint signalling, which monitors the state of the genome prior to DNA replication (G1/S) and chromosome segregation (G2/M). Checkpoint signalling in model systems including mice, Xenopus laevis, Drosophila melanogaster, and the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe have been useful in elucidating these pathways in mammalian cells. An examination of this research, with emphasis on the function of checkpoint proteins, their relationship to DNA repair, and their involvement in oncogenesis is undertaken here.
Business intelligence for social media interaction in the travel industry in Indonesia

Electronic ticket (eticket) provider services are growing fast in Indonesia, makingthe competition between companies increasingly intense. Moreover, most of them have the sameservice or feature for serving their customers. To get back the feedback of their customers, manycompanies use social media (Facebook and Twitter) for marketing activity or communicatingdirectly with their customers. The development of current technology allows the company totake data from social media. Thus, many companies take social media data for analyses. Thisstudy proposed developing a data warehouse to analyze data in social media such as likes,comments, and sentiment. Since the sentiment is not provided directly from social media data,this study uses lexicon based classification to categorize the sentiment of users’ comments. Thisdata warehouse provides business intelligence to see the performance of the company based ontheir social media data. The data warehouse is built using three travel companies in Indonesia.As a result, this data warehouse provides the comparison of the performance based on the socialmedia data.
Nonprofit Organizations in Mexico: A Preliminary Study on Knowledge Creation From the Beneficiaries’ Perspectives

ABSTRACT The purpose of this study is to assess knowledge-creation activities by nonprofit organizations in Mexico from the beneficiaries’ perspectives. The ontological shift Socialization, Externalization, Combination, Interiorization (SECI) model and nonparametric tests were applied to a sample of 429 beneficiaries of 89 nonprofit organizations. The results found socialization was the most important and externalization was the least important aspect of the four types of dynamic knowledge interaction, suggesting an imbalance in knowledge creation, specifically in the conversion from tacit to explicit knowledge, which implies a problem, failure, or explicit barrier between the nonprofit organizations and their beneficiaries. The results further suggest weak links between age and externalization activities, gender and combination activities, and educational attainment and socialization activities. In sum, nonprofit organizations should consider beneficiaries’ individual characteristics when developing activities, disseminating materials, and communicating with the public. The study contributes to our understanding of tacit and explicit knowledge-creation activities by nonprofit organizations in Mexico.
Does Emotional Intelligence Fluctuate within Clinical Depressive Condition?

Objective Emotional intelligence (EI) is regarded an important factor related to psychiatric disorder. Most of previous studies of EI and depression only dealt with EI in present of depressive symptoms. Our study investigated EI both before and after remission of depression and to identify which component of EI is changeable by depression condition. Methods EI was evaluated for 23 depression patients and 44 normal control participants. Adult Emotional Quotient Test (AEQT) was used as subjective EI measure and Emotional Literacy Test (ELT) was used as objective EI measure to both groups. Results During the initial evaluation of the subjective EI, patient group reported significantly lower scores than control group on all AEQT sub-domains except ‘empathy’. However, group difference on ‘utilization’ disappeared after the remission evaluation. There was no significant difference within the objective EI measure. Conclusion According to the result of the study, EI could be sub-divided into trait-dependent EI and state-dependent EI. Further implication, strength and limitation were discussed.
Développement de la iontophorèse comme axe thérapeutique des atteintes microcirculatoires dans la sclérodermie systémique

La sclerodermie systemique (ScS) est une maladie qui peut engager le pronostic vital des malades de facon tres rapide. La pathogenie de la maladie reste encore obscure mais est liee aux atteintes vasculaires probablement en lien avec la fibrose cutanee. La therapeutique de cette maladie est difficile. Aucun traitement etiologique n'existe et la prise en charge est plutot axee sur les traitements des differentes atteintes. La iontophorese cutanee est un dispositif qui permet la diffusion de molecules en solution a travers la peau grâce a une stimulation electrique de maniere non invasive. Cette technique a ete utilisee initialement comme test physiologique. Notre objectif est d'evaluer et de developper la iontophorese therapeutique, notamment avec des molecules vasodilatatrices, pour pouvoir l'utiliser dans des applications therapeutiques telles que la pris en charge des ulcerations digitales (ou troubles trophiques cutanes) de la ScS. Trois parties ont ete developpees. La premiere partie consiste en l'association de deux molecules vasodilatatrices (une per os, le sildenafil, et en iontophorese, le nitroprussiate de sodium (SNP), en etudiant la tolerance de l'association et son effet sur le flux vasculaire cutane chez le volontaire sain (etude INFLUX-VS). La deuxieme partie correspond a un screening de molecules ayant une action vasodilatatrice et etant delivrees en iontophorese chez le rat : l'etude INFLUX-RAT conclue a l'obtention d'une vasodilatation cutanee chez le rat avec les analogues de la prostacycline. La troisieme partie correspond a l'evaluation chez le volontaire sain de la iontophorese des analogues de la prostacycline : l'etude INFLUX-IT-VS conclue a une dilatation du flux sanguin cutane avec le treprostinil et avec une bonne tolerance cutanee et systemique. La derniere partie correspond aux avancees paralleles des travaux tant dans le domaine de la reproductibilite des techniques d'acquisition des signaux du flux sanguin cutane que les etudes realisees avec les patients sclerodermiques a qui on pourrait esperer un jour voir proposer une iontophorese therapeutique.
Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription

Stimulation of quiescent 3T3 cells with purified growth factors or of the pheochromocytoma cell line PC12 with nerve growth factor results in the rapid transient induction of c-fos, c-myc, and actin gene transcription (M.E. Greenberg and E.B. Ziff, Nature [London] 312:711-716; M.E. Greenberg, L.A. Greene, and E.B. Ziff, J. Biol. Chem. 26:14101-14110). We used protein synthesis inhibitors to investigate whether synthesis of new proteins plays a role in the rapid induction and subsequent repression of the transcription of these genes. Pretreatment of quiescent 3T3 cells with the inhibitor anisomycin before growth factor stimulation caused a superinduction of c-fos and c-myc mRNA levels upon growth factor addition. Nuclear runoff transcription analyses of 3T3 cells indicated that anisomycin potentiated c-fos, c-myc, and also actin expression at the transcriptional level, possibly by inhibiting transcriptional repression. Somewhat different results were obtained when PC12 cells were incubated with either anisomycin or cycloheximide. In PC12 cells protein synthesis inhibitors superinduced nerve growth factor activation of c-fos mRNA production but completely abolished the activation of c-myc. The results suggest that in PC12 cells c-fos transcription is activated by a protein-synthesis-independent mechanism, whereas c-myc stimulation requires new protein synthesis. The difference in the effect of anisomycin on growth factor activation of c-myc expression in 3T3 versus PC12 cells may be due to differential stringency of protein synthesis inhibition in the two cells or could reflect cell type differences in c-myc regulation.
Sistem Pendukung Keputusan Pemilihan Supplier Terbaik Telur Bermerk Menggunakan Metode SAW Studi Kasus : PT. GIANT PONDOK KOPI

Kegiatan yang paling penting dilakukan oleh para perusahaan adalah untuk mendapatkan keuntungan. Di sini peran pemasok / supplier sangat berpengaruh bagi pertumbuhan dan kemajuan suatu perusahaan, khususnya pada Giant Supermarket Pondok Kopi. Salah satu produk yang ada pada supermarket ini adalah Telur yang bermerk. Telur bermerk disini dalam artian telur yang ada didalam kemasan (pack), pemasok telur bermerk sangat penting untuk dilakukan penelitian, karena banyaknya barang yang tidak terjual atau tidak banyak yang diminati oleh konsumen. Sehingga perlu adanya pemilihan supplier yang terbaik untuk telur bermerk ini. Pengelolahan data pada penelitian ini menggunakan metode Simple Additive Weighting (SAW). Selain itu,model yang telah dibuat akan diimplementasikan menajdi suatu Sistem Pendukung Keputusan (SPK). Kriteria yang dapat mempengaruhi pemilihan pemasok adalah ketepatan pengirim, kualitas barang, harga barang, dan fleksibiltas. Penelitanini akan diangkat suatu kasus yaitu mencari alternatif terbaik berdasarkan kriteria-kriteria yang telah ditentukan. Guna mencari bobot untuk setiap atribut, kemudian dilakukan peroses perangkingan yang akan menentukan alternatif yang optimal yaitu supplier terbaik. Kata kunci— SAW , Pemilihan supplier, SPK
An Efficient Parallel CMM-CSD Modular Exponentiation Algorithm by Using a New Modified Modular Multiplication Algorithm

This paper presents a new modified Montgomery modular multiplication algorithm based on canonical signed-digit (CSD) representation, and sliding window method. In this modified Montgomery modular multiplication algorithm, signed-digit recoding technique is used in order to increase probability of the zero bits. Also sliding window method is used in order to reduce the multiplication steps considerably. In addition, a new efficient modular exponentiation algorithm based on this new modular multiplication algorithm, CMM method and parallel structure is presented. In this new CMM-CSD modular exponentiation algorithm, not only the common part of modular multiplication is computed once rather than several times but also the modular multiplication and modular squaring operations is performed in parallel. Using this new modular exponentiation algorithm, the security of the cryptosystem increased considerably. The results show that the average number of multiplication steps in the proposed CMM-CSD exponentiation algorithm is reduced considerably. Therefore, the efficiency of the proposed CMM-CSD modular exponentiation algorithm increased considerably in compare with Dusse-Kaliski’s Montgomery algorithm, Ha-Moon’s improved Montgomery algorithm, Wu’s CMM-MSD Montgomery algorithm, Wu et al.’s CMM-SDR Montgomery algorithm and Wu’s CMM-CSD Montgomery algorithm.
Quantized Hall conductance as a topological invariant.

Whenever the Fermi level lies in a gap (or mobility gap) the bulk Hall conductance can be expressed in a topologically invariant form showing the quantization explicitly. The new formulation generalizes the earlier result by Thouless, Kohmoto, Nightingale, and den Nijs to the situation where many-body interaction and substrate disorder are also present. When applying to the fractional quantized Hall effect, we draw the conclusion that there must be a symmetry breaking in the many-body ground state. The possibility of writing the fractionally quantized Hall conductance as a topological invariant is also discussed.
Topographic projection from the optic tectum to the auditory space map in the inferior colliculus of the barn owl

In the barn owl (Tyto alba), the external nucleus of the inferior colliculus (ICX) contains a map of auditory space that is calibrated by visual experience. The source of the visually based instructive signal to the ICX is unknown. Injections of biotinylated dextran amine and Fluoro‐Gold in the ICX retrogradely labelled neurons in layers 8‐15 of the ipsilateral optic tectum (OT) that could carry this instructive signal. This projection was point‐to‐point and in register with the feed‐forward, auditory projection from the ICX to the OT. Most labelled neurons were in layers 10‐11, and most were bipolar. Tripolar, multipolar, and unipolar neurons were also observed. Multipolar neurons had dendrites that were oriented parallel to the tectal laminae. In contrast, most labelled bipolar and tripolar neurons had dendrites oriented perpendicular to the tectal laminae, extending superficially into the retino‐recipient laminae and deep into the auditory recipient laminae. Therefore, these neurons were positioned to receive both visual and auditory information from particular locations in space. Biocytin injected into the superficial layers of the OT labelled bouton‐laden axons in the ICX. These axons were generally finer than, but had similar bouton densities as, feed‐forward auditory fibers in the ICX, labelled by injections of biocytin into the central nucleus of the inferior colliculus (ICC). These data demonstrate a point‐to‐point projection from the OT to the ICX that could provide a spatial template for calibrating the auditory space map in the ICX. J. Comp. Neurol. 421:146–160, 2000. © 2000 Wiley‐Liss, Inc.
Effective Remote Communication for Cloud Backup

: Today we live in a world where tons of data is been generated, so in order to store all these data, we need many numbers of servers and networking which are more expensive in buying and maintaining them which creates more complexity. In order to resolve this problem we had implemented cloud computing i.e it provides IT resources as the service to the user and charge as per their usage. Generally public cloud lacks security and there is a loss of control over the data center so we implement a private cloud in an organization as it has proper security and also there is a complete control over the data center, this private cloud provides us the system and the services like SAAS, PAAS and IAAS limited to an organization. This paper tells us how to establish a private cloud in an organization. When we establish a private cloud there should be a proper backup i.e copying the data for limiting the loss in case of a corruption or failure, 90% of the companies who did not have a backup did not come back to business after 9/11 incident in the Twin Tower disaster in the USA. This is why we need to backup for protection and generally, we use the progressive incremental backup. Generally logs are been used to have a long-term storage and there is a need to have storage efficiency by using compression algorithms like log specific and tradition lossless compression algorithms, the main drawback is that it ignores the semantics of logs so there is no satisfactory compression ratio mainly in the well-structured composition and the similarity between the both. To make better compression ratio of the cloud backup system this paper explains about multi level log compression method. In order to prevent the data being lost due to natural calamities and also few network problem issues, we do remote-backup. In the present society many of the large data centers generally use remote backups for the improvement of system function, it includes heavy communication overhead and potential errors because of the more distance and costly network transmission. To solve this problem we invented a remote communication service called Neptune. It is a cost-effective time-saver method, it transfers huge data even to the far distance data centers. The time saver method in Neptune is deleting the mistakes making a group for similar files. To remove the space between them it uses chunk level duplication and delta compression, the chunk level duplication eliminate wrong files where as the delta compression makes a group of similar files to control the overheads and difficulty, it uses hashing for grouping same files and time-saver method is for quick remote recovery and examine the Neptune by making use of the present world applications linked HP, GOOGLE, MSN when in comparison with state of the art work.
Energy Efficiency and Secure Communication with Power Splitting Energy Harvesting Technique for Single Relay Network

This paper investigates the secrecy performance of a single hop wireless relay network employing power splitting (PS) energy harvesting (EH) technique, using the term secrecy rate. In this network, a relay is present between source and destination to forward signal to the destination and a power beacon provides power to relay and source using EH technique to perform their respective roles. The secrecy rate of this system is analyzed for two cooperative schemes i.e. decode-and-forward (DF) and amplify-and-forward (AF).
EVENT RISK COVENANTS, DESIGN PARAMETERS AND AGENCY ISSUES: A COMPARATIVE STUDY OF HIGH YIELD VERSUS INVESTMENT GRADE BONDS

We analyse security design parameters of 1,115 high yield (HY) and investment grade (IG) event risk covenants (ERC) protected issues between 1986 and 2012 from the agency conflict perspective. We find positive and significant stock price reaction to the issuance of HY but not the IG issues. Although, majority of these issues carry a call provision, we find significant design differences in the call provision between HY and IG issues. We find that HY issues provide strong call protection to mitigate the risk of a call due to ratings upgrade, compromising firm’s financial flexibility; resulting financial distress is mitigated by the ERC. IG issues provide weak call protection to fully exploit growth options however, role of ERC is not apparent. We also find evidence of increase in managerial entrenchment due to the presence of ERC in HY firms however, reduction in agency cost of debt supersedes cost of managerial entrenchment.
Clinical impact of GB virus C viremia on patients with HIV type 1 infection in the era of highly active antiretroviral therapy.

BACKGROUND The influence of GB virus C (GBV-C) viremia on clinical outcomes of patients with human immunodeficiency virus type 1 (HIV-1) infection remains controversial in the era of highly active antiretroviral therapy (HAART). METHODS A prospective observational study was conducted to describe the epidemiology of GBV-C viremia and assess its clinical impact on treatment responses to HAART in 385 HIV-1-infected patients during the period from January 1999 through June 2004. RESULTS A total of 59 patients (15.3%) had detectable GBV-C RNA viremia during a median observation of 3.6 years (range, 1.0-7.0 years); 47 patients (12.2%) had GBV-C viremia at enrollment, and 12 (3.1%) acquired GBV-C infection during follow-up. Thirty-two (68.1%) of the 47 patients with baseline GBV-C viremia had persistent GBV-C viremia. Compared with patients with clearance of GBV-C viremia (n=15) and patients without detectable GBV-C viremia (n=326), patients with persistent GBV-C viremia were more likely to be men who have sex with men (81.3% vs. 60.4%; P=.02), tended to have lower baseline plasma HIV RNA load (HIV RNA load > or =5 log(10) copies/mL, 31.3% vs. 49.4%; P=. 05), and had a higher proportion of isolated anti-hepatitis B core antibody (37.5% vs. 17.2%; P=.005). There was no statistically significant difference in terms of virologic, immunologic, and clinical responses to HAART; occurrence of hepatic events; and mortality among the 3 groups. CONCLUSIONS Persistent GBV-C viremia is significantly associated with male-male sex in HIV-infected patients with advanced immunodeficiency, and persistent GBV-C viremia does not confer short-term benefit in patients receiving HAART.
Toxicological profiling of sediments using in vitro bioassays, with emphasis on endocrine disruption

In vitro bioassays are valuable tools for screening environmental samples for the presence of bioactive (e.g., endocrine‐disrupting) compounds. They can be used to direct chemical analysis of active compounds in toxicity identification and evaluation (TIE) approaches. In the present study, five in vitro bioassays were used to profile toxic potencies in sediments, with emphasis on endocrine disruption. Nonpolar total and acid‐treated stable extracts of sediments from 15 locations in the Rhine Meuse estuary area in The Netherlands were assessed. Dioxin‐like and estrogenic activities (using dioxin‐responsive chemical‐activated luciferase gene expression [DR‐CALUX] and estrogen‐responsive chemical‐activated luciferase gene expression [ER‐CALUX] assays) as well as genotoxicity (UMU test) and nonspecific toxic potency (Vibrio fischeri assay) were observed in sediment extracts. For the first time, to our knowledge, in vitro displacement of thyroid hormone thyroxine (T4) from the thyroid hormone transport protein thransthyretin by sediment extracts was observed, indicating the presence of compounds potentially able to disrupt T4 plasma transport processes. Antiestrogenic activity was also observed in sediment. The present study showed the occurrence of endocrine‐disrupting potencies in sediments from the Dutch delta and the suitability of the ER‐ and DR‐CALUX bioassays to direct endocrine‐disruption TIE studies.
Polysaccharides in Lentinus edodes: Isolation, Structure, Immunomodulating Activity and Future Prospective

Lentinus edodes has been valued as edible and medical resources. Polysaccharides have been known to be the most potent antitumor and immunomodulating substance in Lentinus edodes. In this review, we summarize the current knowledge of the polysaccharides isolated from Lentinus edodes, including extraction and purification methods, chemical structure and chain conformation, the effects on innate and adaptive immunity and their mechanism, relationship between structure and function, and the future prospects.