Miracle-dz/UniFAR-FTUs huggingface dataset:
TopFIND 2.0—linking protein termini with proteolytic processing and modifications altering protein function

Protein termini provide critical insights into the functional state of individual proteins. With recent advances in specific proteomics approaches to enrich for N- and C-terminomes, the global analysis of whole terminomes at a proteome-wide scale is now possible. Information on the actual N- and C-termini of proteins in vivo and any post-translational modifications, including their generation by proteolytic processing, is rapidly accumulating. To access this information we present version 2.0 of TopFIND (http://clipserve.clip.ubc.ca/topfind), a knowledgebase for protein termini, terminus modifications and underlying proteolytic processing. Built on a protein-centric framework TopFIND covers five species: Homo sapiens, Mus musculus, Arabidopsis thaliana, Saccharomyces cerevisiae and Escherichia coli and incorporates information from curated community submissions, publications, UniProtKB and MEROPS. Emphasis is placed on the detailed description and classification of evidence supporting the reported identification of each cleavage site, terminus and modification. A suite of filters can be applied to select supporting evidence. A dynamic network representation of the relationship between proteases, their substrates and inhibitors as well as visualization of protease cleavage site specificities complements the information displayed. Hence, TopFIND supports in depth investigation of protein termini information to spark new hypotheses on protein function by correlating cleavage events and termini with protein domains and mutations.
TRPM4 Regulates Calcium Oscillations After T Cell Activation

TRPM4 has recently been described as a calcium-activated nonselective (CAN) cation channel that mediates membrane depolarization. However, the functional importance of TRPM4 in the context of calcium (Ca2+) signaling and its effect on cellular responses are not known. Here, the molecular inhibition of endogenous TRPM4 in T cells was shown to suppress TRPM4 currents, with a profound influence on receptor-mediated Ca2+ mobilization. Agonist-mediated oscillations in intracellular Ca2+ concentration ([Ca2+]i), which are driven by store-operated Ca2+ influx, were transformed into a sustained elevation in [Ca2+]i. This increase in Ca2+ influx enhanced interleukin-2 production. Thus, TRPM4-mediated depolarization modulates Ca2+ oscillations, with downstream effects on cytokine production in T lymphocytes.
Real-Time Speed Limit Sign Detection and Recognition from Image Sequences

Traffic sign, especially speed limit sign recognition is important in a driver assistance system. In this paper, a robust approach for real-time detection and recognition of speed limit sign is presented. It consists of two major steps: sign detection and sign recognition. In detection stage, Fast Radial Symmetry Transform is utilized to detect possible sign locations. Then the new method proposed, that is named “Largest Containing Circle” is used to segment characters region. In recognition stage, one fuzzy template matching method is applied to coarse recognize the sign number character, Furthermore, we conduct a similar character recognizer based on the local feature vector for fine recognition of the character. Experimental results in different conditions, including sunny, cloudy, foggy and rainy weather demonstrates that most speed limit signs can be correctly detected and recognized with a high accuracy and the average processing time is 15ms per frame on a standard PC.
Placenta as Detected by a Monoclonal Antibody Factor by a Myeloid Leukemia Cell Line ( KPB-M 15 ) and Production of Human Hematopoietic Survival and Growth

Fifty-five hematopoietic cell lines, including 19 T-, 16 B-, S pre-B-, 5 non-T non-B-, 1 erythroid, and 9 myeloid-monocytoidcells, were screened for production of human hematopoietic survival and stem cell growth factor (SCGF) by enzyme immunoassay using anti-SCGF monoclonal antibody. The KPB-M15 myeloid cell line constitutionally secreted a considerable quantity of SCGF, while other Tor myeloid-monocytoid cell lines did not secrete SCGF. Other biomaterials investigated were fetal calf, horse, and human serum; granulocyte-macrophage colonystimulating factor and erythropoietin preparations;human placental con ditioned medium; lectin (phytohemagglutinin, concanavalin A, and pokeweed mitogen); and mixed leukocyte reaction-stimulated leukocyte-con ditioned medium.SCGF was detected only in humanplacental conditioned medium. SCGF produced by the KPB-M15 cells was a protein with a molecular weight of 20,000. The molecule, highly purified by immunoadsorbent affinity chromatography, retained SCGF activity in vitro, e.g., erythroid burst-promoting activity and granulocyte-macrophage-colony potentiation. With the availability of purified SCGF, it is now possible to study in detail the mechanisms regulating hematopoietic stem cells.
A close relationship at z∼ 2: submillimetre galaxies and BzK-selected galaxies

We investigated the relationship between two massive star-forming galaxy populations at redshift z ∼ 2, namely submillimetre galaxies (SMGs) and BzK-selected galaxies (BzKs). Out of 60 SMGs found in the Subaru/XMM-Newton deep field, we collected optical-near-infrared photometry of 28 radio counterparts for 24 SMGs, based on refined sky positions with a radio map for 35 SMGs. We found a correlation between their K-band magnitudes and BzK [≡(z - K) - (B - z)] colours: almost all of the K-faint (K AB > 21.3) radio-detected SMGs have BzK > -0.2, and are therefore BzKs. This result strongly supports the idea of performing direct optical identification of SMGs by searching for BzKs around SMGs. We calculated the formal significance (P' value) for each of the BzK associations around radio-undetected SMGs, and found six new robust identifications, including one double identification. From this analysis, we obtained the current best estimate of the surface density of BzK-selected SMGs, which indicates that only ∼ 1 per cent of BzKs are SMGs. If BzKs are normal disc-like galaxies at z ∼ 2, as indicated by the correlation between their star formation rate and stellar mass and also by dynamical properties, SMGs are likely to be merging BzKs. In this case, a typical enhancement of the star formation rate as a result of merging is a factor of only ∼3, which is an order of magnitude lower than that of local ultraluminous infrared galaxies (ULIRGs). This may indicate that most of the merging BzKs could be observed as SMGs. Considering a possible high fraction of mergers at z ∼ 2 (which will at least be higher than the fraction at z ≤ 1 of ∼ 10 per cent), it is puzzling to find such a low fraction of SMGs in the progenitor population (BzKs).
Context-dependent phone mapping for LVCSR of under-resourced languages

This paper presents a context-dependent phone mapping approach for acoustic modeling of large vocabulary speech recognition for under-resourced languages by leveraging on well trained models of other languages. Generally speaking, phone mapping can be considered as a hybrid HMM/MLP (Hidden Markov Model / Multilayer Perceptron) model where the input of the MLP is phone acoustic scores, e.g. likelihood or posterior scores. In this paper, we use deep neural networks trained with a lot of Malay training data to generate bottleneck and posterior features for the target English acoustic models. We extend the concept of phone mapping by using not only posteriors but also bottleneck feature as the input for phone mapping. Experiments show that the phone mapping technique outperforms the cross-lingual tandem approach signiﬁcantly. In addition, we also show that bottleneck and posterior features contain complementary information. A consistent improvement is obtained by combining these two feature streams to form the input for phone mapping.
Service composition execution optimization based on state transition matrix for cloud computing

It is difficult to select a composite service with the lowest actual executing cost using the existing methods for QoS-aware service composition in cloud computing. By analyzing the dynamic execution process of composite service with state transition matrix, this paper proposes a new QoS aware optimal service composition method. In view of the effect of composite services reliability on the composite service performance, the method regards the cost averaged for one time of successful execution of a composite as its actual executing cost, and then selects the composite services with the aim of minimizing the composite service execution cost. The simulation result shows that the proposed method is superior to other methods in execution cost.
FEEL: Forwarding Data Energy Efficiently with Load Balancing in Wireless Body Area Networks

In this paper, we propose a reliable, energy efficient and high throughput routing protocol for Wireless Body Area Networks (WBANs). In Forwarding Data Energy Efficiently with Load Balancing in Wireless Body Area Networks (FEEL), a forwarder node is incorporated which reduces the transmission distance between sender and receiver to save energy of other nodes. Nodes consume energy in an efficient manner resulting in longer stability period. Nodes measuring electrocardiography (ECG) and glucose level send their data directly to the sink in order to have minimum delay. Simulation results show that FEEL protocol achieves improved stability period and throughput. As a result it helps in continuous monitoring of patients in WBANs.
Le conflit travail-famille-loisirs et l’intention de quitter l’entreprise : une analyse dans le secteur hôtelier au Québec

Cette recherche, realisee aupres de 258 personnes dans le secteur hotelier au Quebec, vise a examiner le role mediateur de l’epuisement professionnel entre les conflits travail-famille et travail-loisirs sur l’intention de quitter, modere par la position hierarchique, le genre, le type d’hotel et le type d’horaires. Les resultats de l’analyse bootstrap et du test de Sobel confirment la mediation proposee. Egalement, les resultats demontrent que les managers percoivent differemment l’effet des conflits sur l’epuisement par rapport aux employes de service. Ils indiquent aussi que le conflit travail-famille a plus d’impact sur l’epuisement chez les hommes que chez les femmes et que le lien entre le conflit travail-loisirs et l’epuisement est plus fort dans les chaines hotelieres par rapport a d’autres types d’organisations.
Bands of Privacy Preserving Objectives: Classification of PPDM Strategies

At present, data mining algorithms are largely the domain of governments, large organisations and academia where they provide useful insight into the data. However, without the ability to assure privacy protection, the availability of datasets for research purposes may be impaired. Moreover, privacy-preservation is essential if data mining is to be permitted widespread use in government and commercial contexts. Indeed, as data mining algorithms become more widespread, even the datasets currently made available under limited release now may become more restricted. In addition, the ambiguous definitions currently in use hinder the assessment of the quality of the privacy preservation. This paper categorises the protection objectives during the data mining process into bands and then presents a reconceptualization of privacy-preserving data mining algorithms from the viewpoint of these bands. Existing algorithms from eight protection strategies are selected as examples to explain the six bands. Significantly, gaps are revealed in the Privacy Preserving Data Mining literature that indicate areas for future research.
Exploring Antecedent Environmental and Organizational Factors to User-Caused Information Leaks: a Qualitative Study

Sensitive company information can leak to unauthorized parties in case employees do not perform effective protective measures while using application systems for their day-to-day tasks. To reduce the risks for such information leakage incidents, many companies require their employees to follow information systems (IS) security policies and promote awareness programs to increase IS security awareness. The design of effective IS security awareness approaches is addressed by existing research. However, understanding how environmental and organizational factors influence organizations individuals’ IS security awareness is limited. Using grounded theory as qualitative research approach we collect empirical data from 22 informants. The interview data of company outsiders and company insiders is analyzed to identify contextual factors and explain associations among them. Our stated propositions help to understand why individuals in one organization are well aware of IS security threats and policies, while another organization’s individuals have a lower level of IS security awareness.
Spatial Keyword Query Processing: An Experimental Evaluation

Geo-textual indices play an important role in spatial keyword querying. The existing geo-textual indices have not been compared systematically under the same experimental framework. This makes it difficult to determine which indexing technique best supports specific functionality. We provide an all-around survey of 12 state-of-the-art geo-textual indices. We propose a benchmark that enables the comparison of the spatial keyword query performance. We also report on the findings obtained when applying the benchmark to the indices, thus uncovering new insights that may guide index selection as well as further research.
Out-of-Pocket Costs and Other Determinants of Access to Healthcare for Children with Febrile Illnesses: A Case-Control Study in Rural Tanzania

Objectives To study private costs and other determinants of access to healthcare for childhood fevers in rural Tanzania. Methods A case-control study was conducted in Tanzania to establish factors that determine access to a health facility in acute febrile illnesses in children less than 5 years of age. Carers of eligible children were interviewed in the community; cases were represented by patients who went to a facility and controls by those who did not. A Household Wealth Index was estimated using principal components analysis. A multivariable logistic regression analysis was performed to understand the factors which influenced attendance of healthcare facility including severity of the illness and household wealth/socio-demographic indicators. To complement the data on costs from community interviews, a hospital-based study obtained details of private expenditures for hospitalised children under the age of 5. Results Severe febrile illness is strongly associated with health facility attendance (OR: 35.76, 95%CI: 3.68-347.43, p = 0.002 compared with less severe febrile illness). Overall, the private costs of an illness for patients who went to a hospital were six times larger than private costs of controls ($5.68 vs. $0.90, p<0.0001). Household wealth was not significantly correlated with total costs incurred. The separate hospital based cost study indicated that private costs were three times greater for admissions at the mission versus public hospital: $13.68 mission vs. $4.47 public hospital (difference $ 9.21 (95% CI: 7.89 -10.52), p<0.0001). In both locations, approximately 50% of the cost was determined by the duration of admission, with each day in hospital increasing private costs by about 12% (95% CI: 5% - 21%). Conclusion The more severely ill a child, the higher the probability of attending hospital. We did not find association between household wealth and attending a health facility; nor was there an association between household wealth and private cost.
Smartphone Addiction and Loneliness in Adolescent

Adolescent nowadays spent most of their time online in the internet or used their smartphone. In consequence, they spent less of their time interact with their friends. It can cause a decreasing number of friends and made them experienced loneliness. Loneliness is a subjective unpleasant experience caused by the degradation of quality and quantity in social relation. Therefore this study aimed to see a correlation between smartphone addiction and loneliness in adolescent. Participants of this study are 356 freshman years students of University of Muhammadiyah Malang, aged 18-22. Data gathered using Smartphone Addiction Scale (SAS) and R-UCLA Loneliness Scale. Result showed, there is a positive correlation between smartphone addiction and loneliness in adolescent (r=0.227; p=0.000).
Prediction of diffraction effects due to irregular terrain on radio wave propagation in the VHF and UHF bands

Many models have been proposed to represent diffraction effects on the propagation of radio waves over irregular terrain in the VHF and UHF bands. Predictions from these models have been compared with results from associated field-strength measurements available in extensive databases that also incorporate the technical parameters of thousands of VHF and UHF links. Some possible sources of the still high values of the standard deviations of errors between predictions and measurements will be identified and discussed, with particular attention to uncertainties on digital elevation models and on the effective Earth's radius, as well as to effects from lateral propagation.
Stochastic Model for Direction Changes of Swimming Bacteria

In this work we introduce a stochastic model to describe directional changes in the movement of swimming bacteria. We use the probability density function (PDF) of turn angles, measured on tumbling E. coli wild-type, to build a Langevin equation for the deflection of the bacterial body swimming in isotropic media. We solved analytically this equation by means of the Green function method and show that three parameters are sufficient to describe the movement: a characteristic time, the steady-state solution and a control parameter. We conclude that the tumble motion, which is manifested as abrupt turns, is primarily caused by the rotational boost generated by the flagellar motor and complementarily by the rotational diffusion introduced by noise. We show that, in the tumble motion, the deflection is a non-stationary stochastic processes during times where the tumble occurs. By tuning the control parameter our model is able to explain small turns of the bacteria around their centers of mass along the run. We show that the deflection during the run is an Ornstein-Uhlenbeck process, which for typical run times is stationary. We conclude that, along the run, the rotational boosts do not exist or are neglectable and that only the rotational diffusion remains. Thus we have a single model to explain the turns of the bacterium during the run or tumble movements, through a control parameter that can be tuned through a critical value that can explain the transition between the two turn behaviours. This model is also able to explain very satisfactory all available statistical experimental data, such as PDFs and average values of turning angles and times, of both run and tumble motions.
Context-dependent JPEG backward-compatible high-dynamic range image compression

Abstract. High-dynamic range (HDR) imaging is expected, together with ultrahigh definition and high-frame rate video, to become a technology that may change photo, TV, and film industries. Many cameras and displays capable of capturing and rendering both HDR images and video are already available in the market. The popularity and full-public adoption of HDR content is, however, hindered by the lack of standards in evaluation of quality, file formats, and compression, as well as large legacy base of low-dynamic range (LDR) displays that are unable to render HDR. To facilitate the wide spread of HDR usage, the backward compatibility of HDR with commonly used legacy technologies for storage, rendering, and compression of video and images are necessary. Although many tone-mapping algorithms are developed for generating viewable LDR content from HDR, there is no consensus of which algorithm to use and under which conditions. We, via a series of subjective evaluations, demonstrate the dependency of the perceptual quality of the tone-mapped LDR images on the context: environmental factors, display parameters, and image content itself. Based on the results of subjective tests, it proposes to extend JPEG file format, the most popular image format, in a backward compatible manner to deal with HDR images also. An architecture to achieve such backward compatibility with JPEG is proposed. A simple implementation of lossy compression demonstrates the efficiency of the proposed architecture compared with the state-of-the-art HDR image compression.
Age-Dependent Neurodegeneration and Alzheimer-Amyloid Plaque Formation in Transgenic Drosophila

β-Amyloid peptides that are cleaved from the amyloid precursor protein (APP) play a critical role in Alzheimer's disease (AD) pathophysiology. Here, we show that in Drosophila, the targeted expression of the key genes of AD, APP, theβ-site APP-cleaving enzyme BACE, and the presenilins led to the generation of β-amyloid plaques and age-dependent neurodegeneration as well as to semilethality, a shortened life span, and defects in wing vein development. Genetic manipulations or pharmacological treatments with secretase inhibitors influenced the activity of the APP-processing proteases and modulated the severity of the phenotypes. This invertebrate model of amyloid plaque pathology demonstrates Aβ-induced neurodegeneration as a basic biological principle and may allow additional genetic analyses of the underlying molecular pathways.
Relationships of Moral Distress among Interprofessional ICU Teams

iv SUMMARY OF STUDY . 1 PROPOSAL . 2 Introduction . 2 Specific Aims . 3 Background and Significance . 3 Approach . 9 Human Subjects . 17 References . 18 MANUSCRIPT . 22 Vincent, H. , Ulrich, E. , Jones, D. , & Engebretson, J. (2018). Relationships of Moral Distress Among Interprofessional ICU Teams.