Miracle-dz/UniFAR-FTUs huggingface dataset:
A Semiotic Approach to Web Service Description

The discovery of suitable web services is a demanding challenge for organisations that plan to benefit from this technology. Strategic objectives, organisational structures, business processes and technology placed in a climate of constant change impact the normative behavioural patterns of people working in all kinds of organisations. Such dynamic conditions can have a profound influence over the discovery of appropriate web services. Advocated in this paper is a semiotic approach to web service description that configures a solution to take into account the dynamic conditions affecting web service discovery. The semiotic approach merges the articulation of dynamic conditions with web service description whilst facilitating the engagement of service providers and consumers in joint actions. Framed by affordance, joint actions capture the changeable normative behavioural patterns of people so that web service utilisation can be harmonised with organisational contexts.
Optimizing Wind Power Hosting Capacity of Distribution Systems Using Cost Benefit Analysis

The penetration of wind power into the electricity grid is growing significantly. A significant portion of this wind power is being installed in distribution systems, of which most are passively operated. Under this operating practice, wind power can only be admitted based on minimum load and maximum generation consideration. This severely limits the wind power hosting capacity of the system. Hence, the use of active-management strategies (AMSs) has been proposed to increase the hosting capacity of distribution systems. This paper incorporates AMSs into two optimization models whose objectives are to maximize the net benefit of distribution system operator and wind farm owner, respectively. The AMSs considered are wind energy curtailment, coordinated on-load tap changer voltage control, and reactive power compensation. The models development is based on a typical medium-voltage distribution system in Sweden although it can easily be adapted to other cases. The application of the model to a distribution system in Sweden shows an increase in hosting capacity of the distribution system by 78% with mere 2.6% curtailed energy. That is, the hosting capacity of the distribution system has almost been doubled by using AMSs.
Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle

The interconnected PI3K and MAPK signaling pathways are commonly perturbed in cancer. Dual inhibition of these pathways by the small-molecule PI3K inhibitor pictilisib (GDC-0941) and the MEK inhibitor cobimetinib (GDC-0973) suppresses cell proliferation and induces cell death better than either single agent in several preclinical models. Using mass spectrometry-based phosphoproteomics, we have identified the RING finger E3 ubiquitin ligase RNF157 as a target at the intersection of PI3K and MAPK signaling. We demonstrate that RNF157 phosphorylation downstream of the PI3K and MAPK pathways influences the ubiquitination and stability of RNF157 during the cell cycle in an anaphase-promoting complex/cyclosome–CDH1-dependent manner. Deletion of these phosphorylation-targeted residues on RNF157 disrupts binding to CDH1 and protects RNF157 from ubiquitination and degradation. Expression of the cyclin-dependent kinase 2 (CDK2), itself a downstream target of PI3K/MAPK signaling, leads to increased phosphorylation of RNF157 on the same residues modulated by PI3K and MAPK signaling. Inhibition of PI3K and MEK in combination or of CDK2 by their respective small-molecule inhibitors reduces RNF157 phosphorylation at these residues and attenuates RNF157 interaction with CDH1 and its subsequent degradation. Knockdown of endogenous RNF157 in melanoma cells leads to late S phase and G2/M arrest and induces apoptosis, the latter further potentiated by concurrent PI3K/MEK inhibition, consistent with a role for RNF157 in the cell cycle. We propose that RNF157 serves as a novel node integrating oncogenic signaling pathways with the cell cycle machinery and promoting optimal cell cycle progression in transformed cells.
HDAC 6 Expression Is Correlated with Better Survival in Breast Cancer

Purpose: The structure and function of chromatin can be altered by modifications to histone. Histone acetylation in vivo is a dynamic reversible process governed by histone acetyltransferases (HATs) and histone deacetylases (HDACs). HDAC6 is a unique isoform among the HDACs, and a gene expression pattern study, with cDNA microarray in MCF-7 cells, showed the HDAC6 gene to be late responsive, estrogen induced, and up-regulated. This led us to hypothesize that there was a link between levels of HDAC6 expression and the metastatic potential of breast cancer and also, therefore, the prognosis of these patients. Experimental Design: In the present study, the level of HDAC6 mRNA expression was analyzed with quantitative real-time reverse transcription-PCR, in 135 female patients with invasive breast cancer. HDAC6 protein expression was also determined by immunohistochemistry. An association was sought between HDAC6 expression and various clinicopathologic factors. Results: HDAC6 mRNA was expressed at significantly higher levels in breast cancer patients with small tumors measuring less than 2 cm, with low histologic grade, and in estrogen receptor and progesterone receptor-positive tumors. By contrast, no relationship was found between HDAC6 mRNA expression and any of the other clinicopathologic factors, namely, age, menopausal status, and axillary lymph node involvement. Patients expressing high levels of HDAC6 mRNA and protein had a better prognosis than those expressing low levels, in terms of disease-free survival. However, multivariate analysis failed to show that HDAC6 mRNA and protein are an independent prognostic factors for disease-free survival and overall survival. Furthermore, the patients with high levels of HDAC6 mRNA tended to be more responsive to endocrine treatment than those with low levels. Specific HDAC6 staining was found in the nucleus of some normal epithelial cells and in the cytoplasm of the majority of cancer cells. Although postmenopausal patients showed higher HDAC6 protein expression, there were no relationship between protein expression and any other clinicopathologic factors. Conclusions: We conclude that the levels of HDAC6 mRNA expression may have potential both as a marker of endocrine responsiveness and also as a prognostic indicator in breast cancer. Additional investigations are warranted concerning the relationship between HDAC6 expression and response to endocrine therapy.
Quality Monitoring Traceability Platform of Agriculture Products Cold Chain Logistics Based on the Internet of Things

In order to realize quality tracing of cold-chain logistics and real time temperature and humidity data acquisition and transmission, based on analysis of the current method for cold-chain logistics data acquisition and transmission, a new method which integrating radio frequency identification (RFID) with wireless sensor network (WSN) was put forward. The system scheme design and network communication protocol was investigated. The RFID based quality traceability platform was designed. This platform can be used to monitor the quality of products and the environment in real time. It can realize all the way traceability of agriculture products and temperature and humidity monitor on cold chain from transport and storage. By comparison with the previous management system about the cold chain logistics, this quality traceability platform can reduce product loss and ensure product quality better.
INFORMED CONSENT AND THE PATIENTS OF BANGLADESH

Abstract: In medical practice, informed consent plays a vital role in making ethical decisions. In recent years, informed consent also appears to be a key issue in biomedical discussion. Several definitions of informed consent have already been proposed. However, the socio-economic conditions of different countries are not the same. Many countries differ culturally as well as in rate of literacy. So, a unified concept of informed consent might not be justified for all contexts. This paper discusses the importance of informed consent, different views regarding informed consent and the limitations of applying one single idea of informed consent in every context. It argues that the most plausible concept of informed consent which is achievable for developing countries, like Bangladesh, is based on care ethics. The paper concludes that informed consent could be a 'natural outcome' and is really not be a barrier in patient-physician relationship if the idea is seen from the perspective of care ethics.
Clinical Efficacy and Safety of Donepezil on Cognitive and Global Function in Patients with Alzheimer’s Disease

This study evaluated efficacy and safety of donepezil hydrochloride (donepezil) at 5 mg/day in patients with mild to moderately severe Alzheimer’s disease for 24 weeks in a double-blind, placebo-controlled comparative trial. In this study, 268 patients were enrolled and 39 of these (15%) were withdrawn. In the evaluable population of efficacy, Protocol-Compatible (PC) analyzed patients (n = 228), better effects than that of placebo were confirmed using two primary efficacy measures: a cognitive performance test, the Japanese version of the Alzheimer’s Disease Assessment Scale – cognitive subscale (ADAS-J cog, p = 0.003) and a clinical global assessment, the Japanese version of the Clinical Global Impression of Change (J-CGIC, p = 0.000). The superiority of donepezil was also shown by secondary measures: the Sum of the Boxes of the Clinical Dementia Rating (CDR-SB), the Mental Function Impairment Scale (MENFIS) and the caregiver-rated modified Crichton scale (CMCS). The same results were obtained in the intention-to-treat (ITT) analysis (n = 263). The incidence of drug-related adverse events was 10% (14/136) in the donepezil and 8% (10/131) in the placebo group; no significant difference was seen between the two groups. The main adverse events were gastrointestinal symptoms, and these were almost all mild, and they all disappeared with continued administration or temporary discontinuation of donepezil. These results indicate that the donepezil appears to be effective and well tolerated in patients with mild to moderately severe Alzheimer’s disease.
Data fusion applied in a back warning system

During the last decades, many accidents occurred when reversing vehicles, our objective is to find a system that reduces the damages in case of backtrack (reducing accidents child injuries, avoiding hitting poles or walls, improving the appreciation of distance). Also this application aims at increasing the vigilance of the driver on the presence an object mostly nearby. The interest of this application is to combine several sources, since the sensor give us different kind of information, so with merging these data with the belief function theory we should decide which objects represent a danger for the vehicle in reverse.
Composition of Bacillus Species in Aerosols from 11 U.S. Cities

ABSTRACT: A PCR‐based heteroduplex assay was used to determine the presence and composition of Bacillus species in 11,059 Environmental Protection Agency PM2.5 aerosol samples from 11 U.S. cities. The assay differentiated three groups: Type A containing Bacillus anthracis and very closely related, often pathogenic, Bacillus cereus and Bacillus thuringiensis strains; Type B containing other B. cereus and B. thuringiensis strains; and a third group of more‐distantly related Bacillus species. Eight of the 11 cities were positive for Bacillus species in 50% or more of the samples, and the percent of aerosol samples that contained the HD Type A group ranged from 3% to 32%. Cities from the eastern half of the United States generally contained a higher frequency and broader diversity of Bacillus species than the western half of the United States. Positive samples were detected throughout the year. These results have implications for pathogen detection in environmental samples, understanding the natural evolution of new pathogenic strains, and incidence of infection caused by strains of the B. cereus subgroup.
The Outer Halos of Very Massive Galaxies: BCGs and their DSC in the Magneticum Simulations

Recent hydrodynamic cosmological simulations cover volumes up to Gpc^3 and resolve halos across a wide range of masses and environments, from massive galaxy clusters down to normal galaxies, while following a large variety of physical processes (star formation, chemical enrichment, AGN feedback) to allow a self-consistent comparison to observations at multiple wavelengths. Using the Magneticum simulations, we investigate the buildup of the diffuse stellar component (DSC) around massive galaxies within group and cluster environments. The DSC in our simulations reproduces the spatial distribution of the observed intracluster light (ICL) as well as its kinematic properties remarkably well. For galaxy clusters and groups we find that, although the DSC in almost all cases shows a clear separation from the brightest cluster galaxy (BCG) with regard to its dynamic state, the radial stellar density distribution in many halos is often characterized by a single Sersic profile, representing both the BCG component and the DSC, very much in agreement with current observational results. Interestingly, even in those halos that clearly show two components in both the dynamics and the spatial distribution of the stellar component, no correlation between them is evident.
Chronic Antigen Stimulation In Vivo Induces a Distinct Population of Antigen-Specific Foxp3−CD25− Regulatory T Cells1

The concept of immune regulation/suppression has been well-established and, besides thymus-derived CD4+CD25+ regulatory T (TR) cells, it became clear that a variety of additional peripherally induced TR cells play vital roles in protection from many harmful immune responses including intestinal inflammation. In the present study, we have analyzed in vivo-induced Ag-specific CD4+ TR cells with respect to their molecular and functional phenotype. By comparative genomics we could show that these Ag-specific TR cells induced by chronic Ag stimulation in vivo clearly differ in their genetic program from naturally occurring thymus-derived CD4+CD25+ TR cells. This distinct population of induced TR cells express neither CD25 nor the TR-associated transcription factor Foxp3. Strikingly, CD25 is not even up-regulated upon stimulation. Despite the lack in Foxp3 expression, these in vivo-induced CD25− TR cells are able to interfere with an Ag-specific CD8+ T cell-mediated intestinal inflammation without significant increase in CD25 and Foxp3 expression. Thus, our results demonstrate that in vivo-induced Ag-specific TR cells represent a distinct population of Foxp3−CD25− TR cells with regulatory capacity both in vitro and in vivo.
Relationships between Volumetric Block Proportions and Overall UCS of a Volcanic Bimrock

Der Beitrag befasst sich mit dem Zusammenhang zwischen Gesteinsblockvolumen und Druckfestigkeit von Ankara Agglomerat. Dieser Fels besteht aus uberwiegend vulkanischem Gestein gemischt mit Tuffmatrix; rosafarbene und schwarze Andesitbblocke mit harter bis sehr harter Konsistenz werden von einer Tuffmatrix mit relativ geringer Festigkeit umgeben. Das Blockvolumen wurde mithilfe eines Bildanalyseverfahrens naherungsweise ermittelt. Die rosafarbenen und schwarzen Andesitblocke des sogenannten Bimrock (Block-in-Matrix Gestein) wiesen erhebliche Farbunterschiede zur Tuffmatrix auf, was die Bildanalyse von schwarz-weis und RGB Farbfotoaufnahmen von Aufschlussen wesentlich erleichterte. Die mithilfe des Bildanalyseverfahrens ermittelten Gesteinsblockabmessungen wurde mit den Schatzungen verglichen, die durch Anwendung der nulldimensionalen „Knotenzahlmethode“ ermittelt wurden. Aufgrund der annahernden Gleichformigkeit der Vulkangesteinsblocke kann angenommen werden, dass die zweidimensionalen Abmessungen des Gesteinsblocks, ermittelt durch die Messung anhand von Fotoaufnahmen, dem Blockvolumen entsprechen. Das gemessene Gesteinsblockvolumen wurde zur annaherungsweisen Bestimmung der einachsigen Druckfestigkeit von Ankara Agglomerat als Funktion des Volumengehalts eines Gesteinsblock verwendet. Hierzu wurden auf Regression basierende Gleichungen entwickelt. Das Verhaltnis zwischen dem Blockvolumen und der Druckfestigkeit von Ankara Agglomerat hat einen nicht linearen Verlauf, was darauf schliesen lasst, dass die Gesamtfestigkeit des Bimrock von der Festigkeit der einzelnen Gesteinblocktypen abhangt. Diese Abhangigkeit mag bedingt sein durch die underschiedlichen Festigkeitseigenschaften zwischen Gesteinsblocken und Felsmatrix und erfordert weiterreichende Untersuchungen.
Callus induction and plantlet regeneration in Withania somnifera (L.) dunal

SummaryCallus induction was observed from hypocotyl, root, and cotyledonary leaf segments, grown on Murashige and Skoog (MS) medium supplemented with various concentrations and combinations of 2,4-dichlorophenoxyacetic acid (2,4-D) and kinetin (KN). Maximum callusing (100%) was obtained from root and cotyledonary leaf segments grown on MS medium supplemented with a combination of 2 mg l−1 (9.1 μM) 2,4-D and 0.2 mg l−1 (0.9 μM) KN. The calluses, when subcultured in the same medium, showed profuse callusing. However, these calluses remained recalcitrant to regenerate regardless of the quality and combinations of plant growth regulators in the nutrient pool. When hypocotyl segments were used as explants, callus induction was noticed in 91% of cultures which showed shoot regeneration on MS medium supplemented with 2 mg l−1 2,4-D and 0.2 mg l−1 KN. These shoots were transferred to fresh medium containing various concentrations and combinations of 6-benzyladenine (BA) and N6-(2-isopentenyl)adenosine (2-iP). Maximum shoot multiplication was observed after 60 d of the second subculture on MS medium containing 2 mg l−1 (8.9 μM) BA. These shoots were rooted best (87%) on MS medium containing 2 mg l−1 (9.9 μM) indole-3-butyric acid (IBA). The plantlets were transferred to the field after acclimatization and showed 60% survival.
A Generalized Model for Predicting Postcompletion Errors

A postcompletion error is a type of procedural error that occurs after the main goal of a task has been accomplished. There is a strong theoretical foundation accounting for postcompletion errors (Altmann & Trafton, 2002; Byrne & Bovair, 1997). This theoretical foundation has been leveraged to develop a logistic regression model of postcompletion errors based on reaction time and eye movement measures (Ratwani, McCurry, & Trafton, 2008). This study further develops and extends this predictive model by (a) validating the model and the general set of predictors on a new task to test the robustness of the model, and (b) determining which specific theoretical components are most important to postcompletion error prediction.
Increasing the security level of analog IPs by using a dedicated vulnerability analysis methodology

With the increasing diffusion of multi-purpose systems such as smart phones and set-top boxes, security requirements are becoming as important as power consumption and silicon area constraints in SoCs and ASICs conception. In the same time, the complexity of IPs and the new technology nodes make the security evaluation more difficult. Indeed, predicting how a circuit behaves when pushed beyond its specifications limits is now a harder task. While security concerns in software development and digital hardware design are very well known, analog hardware security issues are not really studied. This paper first introduces the security concerns for analog and mixed circuits and then presents a vulnerability analysis methodology dedicated to them. Using this methodology, the security level of AMS SoC and Analog IP is increased by evaluating objectively its vulnerabilities and selecting appropriated countermeasure in the earliest design steps.
Analytical Approach in Finding the Semi-Optimum Hollow-Core Bragg Fiber With Minimum Loss

Since it is quite difficult to analytically optimize hollow-core Bragg fibers to have minimum confinement loss without using the Floquet theorem, which does not hold for cylindrical structures, the cylindrical Bragg mirror is approximated by its planar counterpart. For this reason, first, the optimum planar waveguide formed by sandwiching a hollow layer between 1-D Bragg mirrors is found in this paper. The optimization for the dominant transverse-electric mode is analytically performed by using the pointwise wavenumber closely related to the wave admittance. A closed-form expression is then found to relate the propagation constant of this waveguide to the thickness of the hollow layer. This expression is then modified for the cylindrical structure, and the propagation constant is approximately related to the hollow-core diameter of the Bragg fiber to be optimized. The optimum cladding region is then found as if it were planar and a semi-optimum hollow-core Bragg fiber is proposed. Its superiority over conventional hollow-core Bragg fibers is numerically demonstrated by following a rigorous approach.
El salario mínimo : aspectos generales sobre los casos de Colombia y otros países

Este articulo presenta una revision sumaria de la literatura sobre los efectos del salario minimo y las experiencias colombiana e internacional en lo referente a instituciones y practicas de fijacion del salario minimo. El repaso de las experiencias conduce a algunas reflexiones sobre la inflexibilidad relativa de las instituciones latinoamericanas frente a lo que es usual en Estados Unidos y Europa Occidental. A pesar de la alta incidencia del salario minimo en Colombia, se hace evidente la carencia de estudios de mayor trascendencia sobre sus efectos. Se sugiere que ha habido un excesivo uso del mismo como mecanismo de indexacion de otras variables, ademas del salario.
Inter-Rater Reliability of Preprocessing EEG Data: Impact of Subjective Artifact Removal on Associative Memory Task ERP Results

The processing of EEG data routinely involves subjective removal of artifacts during a preprocessing stage. Preprocessing inter-rater reliability (IRR) and how differences in preprocessing may affect outcomes of primary event-related potential (ERP) analyses has not been previously assessed. Three raters independently preprocessed EEG data of 16 cognitively healthy adult participants (ages 18–39 years) who performed a memory task. Using intraclass correlations (ICCs), IRR was assessed for Early-frontal, Late-frontal, and Parietal Old/new memory effects contrasts across eight regions of interest (ROIs). IRR was good to excellent for all ROIs; 22 of 26 ICCs were above 0.80. Raters were highly consistent in preprocessing across ROIs, although the frontal pole ROI (ICC range 0.60–0.90) showed less consistency. Old/new parietal effects had highest ICCs with the lowest variability. Rater preprocessing differences did not alter primary ERP results. IRR for EEG preprocessing was good to excellent, and subjective rater-removal of EEG artifacts did not alter primary memory-task ERP results. Findings provide preliminary support for robustness of cognitive/memory task-related ERP results against significant inter-rater preprocessing variability and suggest reliability of EEG to assess cognitive-neurophysiological processes multiple preprocessors are involved.