Miracle-dz/UniFAR-FTUs huggingface dataset:
Penggunaan Sistem Informasi Akuntansi Berbasis Teknologi Informasi dengan Model TAM pada Hotel di Kabupaten Gianyar

The aim of this study was to determine factors that affect acceptance of accounting information systems based on information technology in hotel Gianyar. Model TAM (Technology Acceptance Model) are used as variables or constructs in this study. TAM model consisted of two factors: perceived of usefulness, perceived ease of use, with the added convenience of perceived of enjoyment. This research was conducted in Gianyar. Sampling was done using judgmental (purposive). The data collection is done by distributing questionnaires to employees of the hotel accounting system of accounting information which has been determined by the users who use the system as a respondent. Data were analyzed using SEM analysis and GSCA (Generalized Structure Component Analysis) as a tool of analysis. The results showed that perceived of usefulness, perceived of ease of use and perceived of enjoyment has significant effect on attitudes. The attitude significantly influence the acceptance of information technology.
STAT3 Genotypic Variation and Cellular STAT3 Activation and Colon Leukocyte Recruitment in Pediatric Crohn Disease

Objectives: Genotypic variation in signal transducer and activator of transcription 3 (STAT3) increases risk for inflammatory bowel disease (IBD), and STAT3-dependent inflammatory networks are induced in the colon in these patients. We hypothesized that STAT3 “A” risk allele carriage would be associated with increased cellular STAT3 activation and colon leukocyte recruitment. Methods: Colonic expression of genes regulating STAT3 signaling and leukocyte recruitment and function was measured in pediatric patients with Crohn disease (CD) stratified by STAT3 genotype. The frequency of colonic pSTAT3+ and CXCR2+ neutrophils was determined using immunohistochemistry. STAT3 tyrosine phosphorylation (pSTAT3) was measured in circulating leukocytes by flow cytometry, and mechanisms regulating STAT3 activation were tested in IBD Epstein-Barr virus (EBV)–transformed lymphocytes (EBL). Results: Colonic expression of interleukin 6 (IL-6), the STAT3 target gene SOCS3, the neutrophil chemoattractants IL-8, CXCL1, and CXCL3, and the neutrophil products S100A8, S100A9, and S100A12 were increased in patients carrying the STAT3 “A” risk allele. The frequency of neutrophils expressing the cognate receptor for IL-8, CXCR2, was increased in colonic biopsies from patients carrying the risk allele, and the frequency of pSTAT3+ or CXCR2+ neutrophils correlated with histologic severity. The frequency of CD4+ lymphocytes and granulocytes expressing pSTAT3 was increased in patients carrying the STAT3 “A” risk allele. EBLs from patients carrying the STAT3 “A” risk allele exhibited increased basal and IL-6–stimulated STAT3 tyrosine phosphorylation, increased transcription of STAT3 and SOCS3 after IL-6 stimulation, and increased membrane localization of the IL-6 receptor, GP130, and Janus-associated kinase 2. Conclusions: The STAT3 “A” risk allele is associated with increased cellular STAT3 activation and upregulation of pathways that promote recruitment of CXCR2+ neutrophils to the gut.
Mutations in Single Hairpin Units of Genetically Fused Subunit c Provide Support for a Rotary Catalytic Mechanism in F0F1 ATP Synthase*

Previously, we generated genetically fused dimers and trimers of subunit c of the Escherichia coli ATP synthase based upon the precedent of naturally occurring dimers in V-type H+-transporting ATPases. Thec 2 and c 3 oligomers have proven useful in testing hypothesis regarding the mechanism of energy coupling. In the first part of this paper, the uncoupling Q42E substitution has been introduced into the second loop of thec 2 dimer or the third loop of thec 3 trimer. Both mutant proteins proved to be as functional as the wild type c 2 dimer or wild type c 3 trimer. The results argue against an obligatory movement of the ε subunit between loops of monomeric subunit c in the c 12 oligomer during rotary catalysis. Rather, the results support the hypothesis that the c-ε connection remains fixed as thec-oligomer rotates. In the second section of this paper, we report on the effect of substitution of the proton translocating Asp61 in every second helical hairpin of thec 2 dimer, or in every third hairpin of thec 3 trimer. Based upon the precedent of V-type ATPases, where the c 2 dimer occurs naturally with a single proton translocating carboxyl in every second hairpin, these modified versions of the E. coli c 2 andc 3 fused proteins were predicted to have a functional H+-transporting ATPase activity, with a reduced H+/ATP stoichiometry, but to be inactive as ATP synthases. A variety of Asp61-substituted proteins proved to lack either activity indicating that the switch in function in V-type ATPases is a consequence of more than a single substitution.
An improved weighted total variation algorithm for compressive sensing

In this paper, we present a new algorithm to achieve faster signal reconstruction with higher quality from fewer measurements compared to the classical l1-based minimization approach. Specifically, for a given noisy signal, firstly, the algorithm detects an index set I that includes components most likely to be a jump and increases over the iterations before all jumps have been detected to update the weights. Secondly, the algorithm for the minimization problem updates all the components of signal according to the weights. We analyze this algorithm, and compare its numerical performance with total variation (TV) algorithm and basis pursuit (BP) algorithm. Our numerical simulations on recovering 1D signal indicate that the proposed algorithm has significant advantages over the classical l1-based minimization approach.
Total Ischaemic Burden European Trial (TIBET). Effects of ischaemia and treatment with atenolol, nifedipine SR and their combination on outcome in patients with chronic stable angina. The TIBET Study Group.

OBJECTIVE To study the relationship between presence or absence of ischaemic events on Holter monitoring and occurrence of a hard or hard+soft endpoint. DESIGN A randomized double-blind parallel group study of atenolol, nifedipine and their combination, with ambulatory monitoring off-treatment and after 6 weeks of randomized treatment and prospective follow-up of 2 years on average. SETTING Europe. SUBJECTS 682 men and women with a diagnosis of chronic stable angina and who were not being considered for surgery. MAIN OUTCOME Hard endpoints were cardiac death, nonfatal myocardial infarction and unstable angina; soft endpoints were coronary artery bypass surgery, coronary angioplasty and treatment failure. RESULTS The study showed no evidence of an association between the presence, frequency or total duration of ischaemic events on Holter monitoring, either on or off treatment, and the main outcome measures. There was a non-significant trend to a lower rate of hard endpoints in the group receiving combination therapy. Compliance, as measured by withdrawal from trial medication, was clearly poorest in the nifedipine group with similar withdrawal rates in the atenolol and combination therapy groups. CONCLUSION The recording of ischaemic events in 48 h Holter monitoring failed to predict hard or hard+soft endpoints in patients with chronic stable angina.
Enhanced S-cone syndrome in a Japanese family with a nonsense NR2E3 mutation (Q350X).

PURPOSE To describe the clinical characteristics of a Japanese male patient with enhanced S-cone syndrome (ESCS) and investigate the existence of mutations in the NR2E3 gene, which encodes a photoreceptor cell-specific nuclear receptor. METHODS Fundus examinations, fluorescein angiography, colour vision tests, spectral sensitivity, and full-field and spectral electroretinography were performed. Mutation screening of the NR2E3 gene was performed with polymerase chain reaction (PCR) amplification and direct sequencing. RESULTS We identified a novel homozygous mutation (c.1048C > T), that converts glutamine (CAA) to a termination codon (TAA) at amino acid position 350. The subject's unaffected parents were heterozygous for the mutation, consistent with autosomal recessive transmission. The electroretinographic findings revealed that the patient had neither rod nor 30-Hz flicker responses but did have cone responses with large a-wave and low b-wave amplitudes, similar to the rod-plus-cone responses, and also substantial short wavelength-sensitive (S) cone and extremely diminished long/middle wavelength-sensitive (L/M) cone responses. In the right eye, spectral sensitivity in the fovea revealed both functional S-cone and remarkably reduced L- and M-cone sensitivities, which was compatible with the decreased visual acuity (VA) and red/green colour vision defects noted in this eye. In contrast, the patient had good VA and normal red/green colour vision in the left eye. CONCLUSION The nonsense mutation results in a truncated NR2E3 protein lacking 61 amino acids within the ligand-binding domain (LBD) that consists of 190 amino acids of the C-terminus end. Therefore, null function of the LBD is likely to cause ESCS in the patient. The clinical findings for this patient suggest that his left eye, with its functional L/M- and S-cones, was at an earlier stage of the syndrome than his right eye.
Migration human capital formation and long-run output.

Interest in the effects of labor migration on the receiving economy has not produced ample insights regarding its long-run consequences.The analysis of the transition and steady-state repercussions of migration that arise even if migration has no effect at all on standard labor market variables such as wages and employment is yet to be pursued. This paper takes a step in this direction. We focus on one particular characteristic of migrants viz. the level of human capital and explore its repercussions. (EXCERPT)
Lateralized agonistic responses and hindlimb use in toads

The recent discovery of forepaw preferences (handedness) in toad species has provided some insight into the evolution of brain lateralization. We tested the prediction that, as in higher vertebrates, visual lateralization and other motor preferences (footedness) also exists in toad species. During feeding periods, South American cane toads, Bufo marinus, showed a population bias to strike with the tongue at other toads occupying their left visual field. This is the first demonstration of lateralized visual behaviour in an amphibian species. Tongue striking at an individual's eyes or head may sometimes delay its approach to prey already seen by the attacker, or may dislodge prey from its mouth. In addition, we report hindlimb preferences (footedness) for contact righting in three species of toad (B. marinus, the European green toad, B. viridis, and the European common toad, B. bufo). After being fully overturned on to their back on a horizontal surface, toads initiated and completed righting using the hindlimbs and with only perfunctory use of the forepaws. Together, the findings of visual lateralization and footedness demonstrate that in toads, as in higher vertebrates, behavioural lateralization is not restricted to handedness. The hypothesis that lateralized brain functions in birds and mammals might have arisen from a common lateralized ancestor is therefore supported. Copyright 1998 The Association for the Study of Animal Behaviour.
The spectrum of conditions mimicking polymyalgia rheumatica in Northwestern Spain.

OBJECTIVE To examine the spectrum and the main clinical data of patients presenting with polymyalgia symptoms who have conditions other than polymyalgia rheumatica (PMR) or PMR associated with giant cell arteritis (GCA) during a 10 year period in Northwestern Spain. METHODS Clinical records of patients presenting with polymyalgia symptoms diagnosed at the Hospital Xeral-Calde Lugo from 1987 to 1996 were reviewed by rheumatology staff members. Patients were considered as having a condition suggestive of PMR if they met the following criteria: (1) Age > or =50 years at the onset of symptoms; (2) severe bilateral pain associated with morning stiffness for > 1 mo in at least 2 of 3 areas: neck, shoulder, and/or pelvic girdle; (3) erythrocyte sedimentation rate at the time of diagnosis > or =40 mm/h. Patients with pure PMR or with PMR associated with GCA were excluded from study. RESULTS Twenty-three of the 208 patients (age 67.8 +/- 9.0 yrs) presenting with PMR symptoms were finally diagnosed as having conditions different from PMR and GCA. Men outnumbered women (61%). Malignancies and rheumatic diseases, especially seronegative symmetrical polyarthritis (SSP), were the most common entities. Elderly patients with solid malignancies had a poor response to low doses of prednisone. In patients with hematologic malignancies atypical symptoms of PMR such as lack of accentuation of symptoms with movement and a more diffuse continuous aching were observed. During followup 5 patients developed episodes of SSP (median duration 13 months, range 5 to 24), particularly in both hands, satisfying the American College of Rheumatology 1987 criteria for rheumatoid arthritis. However, arthritis responded promptly to corticosteroids with no disease progression. No cortical erosions or new episodes of PMR were seen in these patients after a followup of 6.8 +/- 2.6 years. With the exception of these 5 patients, duration of polymyalgia symptoms was not longer than 3 months from the onset of polymyalgia symptoms until a specific diagnosis was made. CONCLUSION Polymyalgia symptoms are not uncommon as presenting manifestations of a wide spectrum of conditions. Special concern about the presence of diseases different from PMR or GCA must be considered in patients presenting with atypical symptoms of PMR. Also, the possibility of developing a SSP has to be considered during the followup of these patients.
Entrepreneurship and Social Capital: Examining the Association in Deprived Urban Neighbourhoods

Spatial approaches to examining entrepreneurship have increasingly built on theories of social capital. However, the nature and extent of local social capital in less successful deprived communities remains under researched and inadequately understood. This article examines the association between social capital and entrepreneurship in a deprived urban neighbourhood in the city of Leeds, UK as a means of contributing to an improved theoretical understanding of how space moderates this association. It is found that social capital has a strong association with patterns of entrepreneurship in deprived urban neighbourhoods, with the potential impacts being both positive and negative. The forms of social capital are found to differ from that found in more affluent localities, with a prevalence of bonding social capital as the key facilitator of entrepreneurship, which may help in the early stages of venture development, but which over time may become a constraint. Also, a lack of the bridging social capital associated with entrepreneurial success is found within the locality. From a policy perspective, it is recommended that policymakers responsible for entrepreneurship in deprived urban neighbourhoods should seek to enhance initiatives for developing social capital which incorporate local businesses, residents and local government agencies.
Ketamine decreases plasma catecholamines and improves outcome from incomplete cerebral ischemia in rats.

Central neuroexcitatory receptors (N-methyl-D-aspartate [NMDA], non-NMDA) may affect outcome from cerebral ischemia by altering sympathetic nervous system activity. We tested whether ketamine, an NMDA antagonist, and NBQX, a non-NMDA antagonist, improve outcome from incomplete cerebral ischemia in the rat and whether a change in outcome is related to changes in plasma catecholamines. There were five treatment groups: group 1 (control, n = 10) received a fentanyl infusion at a rate of 25 microgram.kg-1.h-1 and ventilation with 70% N2O in O2. Group 2 (n = 10) received the same anesthetic treatment and were given an intraperitoneal injection of 30 mg/kg NBQX 15 min prior to ischemia. Group 3 (n = 10) received a ketamine infusion of 1.0 mg.kg-1.min-1 and ventilation with room air. Group 4 (n = 10) received a ketamine infusion of 1.5 mg.kg-1.min-1. Group 5 received a ketamine infusion of 1 mg.kg-1.min-1 plus a 6 ml/kg intraperitoneal injection of 40% glucose solution 15 min before the start of ischemia. Ischemia was produced by right common carotid ligation combined with hemorrhagic hypotension to 35 mmHg for 30 min. Blood gases, pH, and skull temperature were controlled during ischemia. Plasma glucose increased during ischemia in all groups but was lower in ketamine-anesthetized rats (groups 3 and 4). Glucose-loaded ketamine-anesthetized rats (group 5) had plasma glucose concentrations similar to the control group. Plasma epinephrine and norepinephrine concentrations were significantly less in ketamine-anesthetized rats (groups 3, 4, and 5) during ischemia compared to controls (P less than 0.05). Neurologic outcome was significantly better (P less than 0.05) in all ketamine-treated rats (groups 3, 4, and 5) compared to the control group, regardless of plasma glucose concentration during ischemia. NBQX did not improve neurologic outcome. These results suggest that ketamine improves neurologic outcome from incomplete cerebral ischemia by a mechanism related to a decrease in plasma catecholamine activity.
Consistent Response of Indian Summer Monsoon to Middle East Dust in Observations and Simulations

Abstract. The response of the Indian summer monsoon (ISM) circulation and precipitation to Middle East dust aerosols on sub-seasonal timescales is studied using observations and the Weather Research and Forecasting model coupled with online chemistry (WRF-Chem). Satellite data show that the ISM rainfall in coastal southwest India, central and northern India, and Pakistan is closely associated with the Middle East dust aerosols. The physical mechanism behind this dust–ISM rainfall connection is examined through ensemble simulations with and without dust emissions. Each ensemble includes 16 members with various physical and chemical schemes to consider the model uncertainties in parameterizing short-wave radiation, the planetary boundary layer, and aerosol chemical mixing rules. Experiments show that dust aerosols increase rainfall by about 0.44 mm day−1 (~10 % of the climatology) in coastal southwest India, central and northern India, and north Pakistan, a pattern consistent with the observed relationship. The ensemble mean rainfall response over India shows a much stronger spatial correlation with the observed rainfall response than any other ensemble members. The largest modeling uncertainties are from the boundary layer schemes, followed by short-wave radiation schemes. In WRF-Chem, the dust aerosol optical depth (AOD) over the Middle East shows the strongest correlation with the ISM rainfall response when dust AOD leads rainfall response by about 11 days. Further analyses show that increased ISM rainfall is related to enhanced southwesterly monsoon flow and moisture transport from the Arabian Sea to the Indian subcontinent, which are associated with the development of an anomalous low-pressure system over the Arabian Sea, the southern Arabian Peninsula, and the Iranian Plateau due to dust-induced heating in the troposphere. The dust-induced heating in the mid-upper troposphere is mainly located in the Iranian Plateau rather than the Tibetan Plateau. This study demonstrates a thermodynamic mechanism that links remote desert dust emissions in the Middle East to ISM circulation and precipitation variability on sub-seasonal timescales, which may have implications for ISM rainfall forecasts.
‘Immigrant paid caregivers’ and primary caregivers' burden

In Italy the large majority (80%) of people affected by Alzheimer’s disease (AD) and associated disorders are cared for at home by informal caregivers, mainly daughters and spouses (Schulz and Martire 2004; Zanetti et al., 1998). It is well known that Caregivers of patients with a demented illness experience years of emotional and physical distress. During the last few years a growing number of Italian families have seeked the help of immigrant females who give full time assistance to the demented patients in their homes. These immigrant paid caregivers, mainly from East European Countries, constitute a new element in the actual informal caregiver network. The purpose of the present study is to evaluated the influence of immigrant paid caregivers on caregivers’ burden.
A new degradation mechanism and its role on negative bias temperature instability in metal-oxide-semiconductor devices

For the first time, an experimental investigation of dopant passivation/depassivation in the silicon substrate of metal-oxide-semiconductor (MOS) devices is presented during and after negative bias temperature stress (NBTS). It is believed that dopant passivation/depassivation is caused by hydrogen diffusion into the substrate forming complex with the dopant during NBTS and back diffusion of hydrogen from the passivated dopant atom during relaxation phase, respectively. The source of the diffusing hydrogen species responsible for dopant passivation during NBTS is the atomic hydrogen (Ho) liberated during interface state (Nit) generation by the hot electron impact with the Si3 ≡ SiH bonds at the Si/SiO2 interface. Dopant passivation mechanism significantly contributes in the measured threshold and flatband voltage shifts ΔVT and ΔVfb, respectively during NBTS. We propose that the experimentally observed new degradation phenomena should be taken into account in evaluation of the NBTI induced oxide charge trapping and interface trap creation.
Intruders and intrusion detection systems — An overview

With rapid advancement in telecommunication sub-domains like Internet of Things (IoT), Internet of Energy (IoE), Internet of Vehicles (IoV), Next Generation Networks (5G) and Big Data, the strength, intensity and effectiveness of intruders is also evolving. Intruders are ready to challenge modern advancement in the domain of electronic warfare. The traditional TCP/IP protocol stack does not have the capability to defend against modern threats posed by intruders, therefore, major revision, from security point of view, is mandatory. In this paper a brief overview of intruders is provided with respect to each layer of TCP/IP protocol stack. Advancements in Intrusion Detection Systems (IDS) for detection of intruders are provided in chronological order. In an unending war between parallel advancements in technologies and evolutions of intruders, an intrusion detection system is always needed that works at each layer of TCP/IP protocol stack and covers entire spectrum of threats.
A 2.2 Å resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding.

A sparse-matrix screen for new crystallization conditions for the USP7 catalytic domain (USP7CD) led to the identification of a condition in which crystals grow reproducibly in 24-48 h. Variation of the halide metal, growth temperature and seed-stock concentration resulted in a shift in space group from P21 with two molecules in the asymmetric unit to C2 with one molecule in the asymmetric unit. Representative structures from each space group were determined to 2.2 Å resolution and these structures support previous findings that the catalytic triad and switching loop are likely to be in unproductive conformations in the absence of ubiquitin (Ub). Importantly, the new structures reveal previously unobserved electron density for blocking loop 1 (BL1) residues 410-419. The new structures indicate a distinct rearrangement of the USP7 BL1 compared with its position in the presence of bound Ub.