Miracle-dz/UniFAR-FTUs huggingface dataset:
Understanding fundamental database operations on modern hardware

We live in an interconnected digital society, where many companies like e.g. Google, Facebook, and Twitter gather and manage tremendous amounts of data every day. The ongoing rise of mobile computing and the availability of more and more sensor data, e.g. from smart meters, increases the amount of data that is produced every day. Several different architectures have evolved to cope with these vast amount of data over the years. Traditionally, mainframes were used to handle huge amounts of data. However, the mainframe has to renew itself to allow for modern data analytics to be efficient and affordable. Advances in the main memory capacity led to the development of in-memory databases architectures, run on many-core non-uniform memory access (NUMA) machines that can handle terabytes of data on a single machine. As another architecture Google developed MapReduce, a distributed framework for data processing on hundreds or even thousands of commodity machines, to handle data that cannot be stored or processed by a single machine, even if it has a capacity in the range of terabytes. This thesis consists of three independent parts, as we investigate different fundamental database operations on three different hardware environments mentioned before in three independent projects. In the first project we look at recently published relational equi-join algorithms on modern many-core NUMA servers with large main memory capacities and introduce our own variants of those algorithms. Afterwards, in a second project we investigate how to introduce efficient static and adaptive indexing into the open source Hadoop MapReduce framework, which runs on a cluster of commodity machines. In that project we will also introduce and investigate the Adaptive Index Replacement problem, a variant of the online Index Selection problem. Finally, in the third project we investigate how to bring analytical workloads to the IBM System Z mainframe and introduce a new hardware component that allows us to accelerate filtering and aggregation on large in-memory column stores.
Degradation of the proto-oncogene product c-Fos by the ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes

The transcription factor c-Fos is a short-lived cellular protein. The levels of the protein fluctuate significantly and abruptly during changing pathophysiological conditions. Thus, it is clear that degradation of the protein plays an important role in its tightly regulated activity. We examined the involvement of the ubiquitin pathway in c-Fos breakdown. Using a mutant cell line, ts20, that harbors a thermolabile ubiquitin-activating enzyme, E1, we demonstrate that impaired function of the ubiquitin system stabilizes c-Fos in vivo. In vitro, we reconstituted a cell-free system and demonstrated that the protein is multiply ubiquitinated. The adducts serve as essential intermediates for degradation by the 26S proteasome. We show that both conjugation and degradation are significantly stimulated by c-Jun, with which c-Fos forms the active heterodimeric transcriptional activator AP-1. Analysis of the enzymatic cascade involved in the conjugation process reveals that the ubiquitin-carrier protein E2-F1 and its human homolog UbcH5, which target the tumor suppressor p53 for degradation, are also involved in c-Fos recognition. The E2 enzyme acts along with a novel species of ubiquitin-protein ligase, E3. This enzyme is distinct from other known E3s, including E3 alpha/UBR1, E3 beta, and E6-AP. We have purified the novel enzyme approximately 350-fold and demonstrated that it is a homodimer with an apparent molecular mass of approximately 280 kDa. It contains a sulfhydryl group that is essential for its activity, presumably for anchoring activated ubiquitin as an intermediate thioester prior to its transfer to the substrate. Taken together, our in vivo and in vitro studies strongly suggest that c-Fos is degraded in the cell by the ubiquitin-proteasome proteolytic pathway in a process that requires a novel recognition enzyme.
CHE-3, a cytosolic dynein heavy chain, is required for sensory cilia structure and function in Caenorhabditis elegans.

Forward genetic screens using novel assays of nematode chemotaxis to soluble compounds identified three independent transposon-insertion mutations in the gene encoding the Caenorhabditis elegans dynein heavy chain (DHC) 1b isoform. These disruptions were mapped and cloned using a newly developed PCR-based transposon display. The mutations were demonstrated to be allelic to the che-3 genetic locus. This isoform of dynein shows temporally and spatially restricted expression in ciliated sensory neurons, and mutants show progressive developmental defects of the chemosensory cilia. These results are consistent with a role for this motor protein in the process of intraflagellar transport; DHC 1b acts in concert with a number of other proteins to establish and maintain the structural integrity of the ciliated sensory endings in C. elegans.
Transesophageal Endoscopic Therapies for Gastroesophageal Reflux Disease

Medical Policy provides general guidance for applying Blue Cross of Idaho benefit plans (for purposes of Medical Policy, the terms “benefit plan” and “member contract” are used interchangeably). Coverage decisions must reference the member specific benefit plan document. The terms of the member specific benefit plan document may be different than the standard benefit plan upon which this Medical Policy is based. If there is a conflict between a member specific benefit plan and the Blue Cross of Idaho’s standard benefit plan, the member specific benefit plan supersedes this Medical Policy. Any person applying this Medical Policy must identify member eligibility, the member specific benefit plan, and any related policies or guidelines prior to applying this Medical Policy. Blue Cross of Idaho Medical Policies are designed for informational purposes only and are not an authorization, explanation of benefits or a contract. Receipt of benefits is subject to satisfaction of all terms and conditions of the member specific benefit plan coverage. Blue Cross of Idaho reserves the sole discretionary right to modify all its Policies and Guidelines at any time. This Medical Policy does not constitute medical advice.
Effect Of Liability Of Foreignness And Family Ownership On Cross-Listing Location Choice

Firms incur liability of foreignness (LOF) when they expand their businesses to foreign countries. This study examines the applicability of LOF in the context of financing in a foreign capital market. Using an alternative-specific conditional logit model, we investigate the cross-listing decisions of firms from 28 countries that select among eight target destinations from 1994 to 2008. These firms target capital markets with lower LOF, which is measured by institutional, economic, geographic, and cultural distance. Such preference is particularly stronger for firms with higher levels of family ownership, suggesting family owners’ tendency to be averse to risk is also manifested in financing context.
Paranoid (Delusional) Disorder Associated with Tuberothalamic Artery Territory Infarction

Neuropsychological, behavioral and mood disturbances are the different aspects of the thalamic lesions [1, 2], especially in circumscribed thalamic infarction [3, 4]. Delusional disorder due to a thalamic lesion has not been reported previously in detail. I report here the clinical and neuropsychological data of a patient with acute infarction in the tuberothalamic artery territory who developed acute paranoid (delusional) disorder. A 75-year-old hypertensive right-handed housewife suddenly noted transient alteration of consciousness and confusion, followed 2 days later by remarkable behavioral changes. On admission at hospital after 3 days of ictus, the patient was well oriented to place, with small errors to time. She had no history of depression or dementia. She had persecutory delusions, distrusted relatives and was suspicious about her children with perverse mood. She said that her spouse and children were unfaithful and wanted to steal her money from her pocketbook. She repeatedly attempted to call the police and obtain justice through appealing government agencies. Symptoms such as feeling of being exploited and denying trustworthiness of relatives lasted 3 months after ictus onset. Neurological examination revealed a slight emotional left-sided facial paresis. Fine motility of the fingers was slowed on the left side. There were no other neurological symptoms. Blood pressure was 180/100 mm Hg. Neuropsychologic examination revealed no language abnormality. She had tactile and visual extinction on simultaneous bilateral stimulation. Spontaneous drawing of a cube and a house was impaired. The copy of a Rey complex figure was impaired (15 points) with perseveration on the right side of the paper. The Rey auditory verbal learning test (15 words of Rey; total 25: 6-6-5-4-4) was not sufficient. The Wisconsin card sorting test (0 series realized) and Stroop test (1 min 50 s) were markedly disturbed. Standard blood and urine tests were within normal ranges. EKG showed left ventricular hypertrophy. T2-weighted MRI done 1 week after admission showed an isolated hyperintense lesion in the anterior part of the right thalamus, suggestive of an infarct in the territory of the right tuberothalamic artery (fig. 1). Magnetic resonance angiography demonstrated multifocal atheromatous disease of the carotid and basilar arteries. Cerebral SPECT ([99mTc] HMPAO) revealed hypoperfusion in the right medial frontal area suggesting a frontal metabolic dysfunction (fig. 2). She was treated by 5 mg/day haloperidol for her persecutory delusions during 3 months which resolved after this period. Misinterpretation of events is common in brain disease, especially in dementia, toxic-metabolic disturbances and closed Fig. 1. Axial T2-weighted MRI whowing an infarct in the right tuberothalamic artery territory.
Varicella Zoster Virus Immediate Early Protein ORF 61 abrogated 1 IRF 3-mediated innate immune response through degradation of activated IRF 3 2 3

3 Huifang Zhu 1, , Chunfu Zheng 1, #, *, Junji Xing , Shuai Wang , Shuping Li , Rongtuan 4 Lin , and Karen L. Mossman 4 5 6 1 Molecular Virology and Viral Immunology Research Group, State Key Laboratory of 7 Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071 China. 8 2 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First 9 Affiliated Hospital, School of Medicine, Zhejiang University and Key Laboratory of 10 Infectious Diseases, Zhejiang 310058 China. 11 3 The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, 12 Department of Medicine, McGill University, Montreal, Quebec, H3T 1E2 Canada. 13 4 The Department of Pathology and Molecular Medicine, Institute for Infectious Disease 14 Research, McMaster University, Hamilton, Ontario, L8N 3Z5 Canada 15 # These two authors contributed equally to the work. 16 * Corresponding author: 17 Chunfu Zheng, Ph. D. 18 Wuhan Institute of Virology, Chinese Academy of Sciences, 19 44 Xiaohongshan Wuchang, Wuhan 430071 China 20 Tel/Fax: +86-27-8719-8676 21 E-mail: zheng.alan@hotmail.com 22 Running title: VZV ORF61 as an antagonism of the IFN-β pathway 23 Abstract word count: 249 24 Text word count: 4490 25 Number of Figures: 9 26
Meta-Analysis of Differentiating Mouse Embryonic Stem Cell Gene Expression Kinetics Reveals Early Change of a Small Gene Set

Stem cell differentiation involves critical changes in gene expression. Identification of these should provide endpoints useful for optimizing stem cell propagation as well as potential clues about mechanisms governing stem cell maintenance. Here we describe the results of a new meta-analysis methodology applied to multiple gene expression datasets from three mouse embryonic stem cell (ESC) lines obtained at specific time points during the course of their differentiation into various lineages. We developed methods to identify genes with expression changes that correlated with the altered frequency of functionally defined, undifferentiated ESC in culture. In each dataset, we computed a novel statistical confidence measure for every gene which captured the certainty that a particular gene exhibited an expression pattern of interest within that dataset. This permitted a joint analysis of the datasets, despite the different experimental designs. Using a ranking scheme that favored genes exhibiting patterns of interest, we focused on the top 88 genes whose expression was consistently changed when ESC were induced to differentiate. Seven of these (103728_at, 8430410A17Rik, Klf2, Nr0b1, Sox2, Tcl1, and Zfp42) showed a rapid decrease in expression concurrent with a decrease in frequency of undifferentiated cells and remained predictive when evaluated in additional maintenance and differentiating protocols. Through a novel meta-analysis, this study identifies a small set of genes whose expression is useful for identifying changes in stem cell frequencies in cultures of mouse ESC. The methods and findings have broader applicability to understanding the regulation of self-renewal of other stem cell types.
Building social CRM framework on enterprise architecture framework using value chain process approach

Customer Relationship Management in this social media era (which is known as Social CRM or CRM 2.0) requires a quite different treatment compared to the previous one (or often referred to as Traditional CRM or CRM 1.0). The use of social media in the Social CRM has changed the role of the company and the customer, which was originally a corporate centric to currently a customer centric. Universities and colleges are a different service company compared to other kind of service companies in general term. Social CRM Framework is needed in this higher education sector because their customers (students) are very expertise in the use of technology. It makes this generation very familiar in utilizing social media. This Social CRM Framework is built on the Enterprise Architecture (EA) framework, results an information system outcome since Enterprise Architecture 672 Meyliana and Eko K. Budiardjo can bridge the speed gap between business changes with the information technology change. The EA used is the Zachman Framework and Architecture of Integrated Information System (ARIS) Framework. The mapping results between Social CRM Frameworks and EA has produces 6 cells, namely the data, time, network, people, function and motivation. This paper discuss how to fill in the function cell and people cell using the Value Chain Process (is called the Higher Education Value Chain) and the APQC Process Classification FrameworkSM approach which is made into business process outcome, then this business process will be described to be business process model and workflow model (organization unit and work product).
A STUDY ON CUSTOMER ATTITUDE TOWARDS SERVICE QUALITY OF PRIVATE SECTOR BANKS IN KRISHNAGIRI DISTRICT

Banking sector is the backbone of any financial system of the economy. Public sector banks play an important role in the development of developing economies by mobilization of resources and their better allocation. The service quality has gained importance in last decade due to its unique characteristics of services involving intangibility, inseparability, variability and perishability. A larger option for the customer is getting translated into a larger demand for financial products, and customization of services is fast becoming the norm than a competitive advantage. Public sector banks in India have fast emerged as one of the major drivers of the banking industry and have witnessed enormous growth in the recent past. In this chapter the researcher has reviewed the various services offered by the select public sector banks in Krishnagiri District.
Leucocyte Variation, an Insight of Host Defenses During Hymenolepiasis and Restoration with Praziquantel

Haematological studies in helminthiasis reveal drastic alterations in the white blood cells (leucocytes), and its various components like neutrophils, lymphocytes, monocytes and eosinophils. The use of proper anthelmintic agent, restores normalcy in the infected host. These variations during helminth infections reflect the host defense status in combating the parasitic attack. The present study involves the evaluation of these total and differential haematological alterations, induced in the laboratory mouse Mus musculus, infested with the intestinal helminth, Hymenolepis nana (dwarf tapeworm), and treated with the praziquantel, using an automatic Coulter Counter.
Linear detection schemes for MIMO UW-OFDM

A new signaling concept, known as unique word — orthogonal frequency division multiplexing (UW-OFDM), has been introduced recently. It has been shown that UW-OFDM has better spectral properties and also a superior bit error ratio (BER) performance over conventional cyclic prefix (CP) based OFDM. In UW-OFDM, the CPs are replaced by deterministic sequences, the so-called unique words (UWs). This is achieved by adding redundancy in the frequency domain with the help of a code generator matrix at the transmitter which introduces correlation between the data symbols. A superior BER performance is achieved if the code generator matrix is utilized efficiently in the detection procedure. In wireless communication systems multiple-input multiple-output (MIMO) techniques are widely used to improve the overall spectral and energy efficiency by exploiting the multiple antennas. So far, the performance of UW-OFDM has been well investigated for single-input single-output (SISO) systems. In this work, we expand our investigation of UW-OFDM to MIMO systems and propose two detection approaches. We show that similar to CP-OFDM, a subcarrier wise detection is also possible for UW-OFDM. But in addition an efficient code generator demodulator is required to take advantage of the correlation introduced in the data symbols. The results show that UW-OFDM outperforms CP-OFDM significantly but requires a higher computational complexity.
Risk on The Johannesburg Stock Exchange

AbstractThe Capital Asset Pricing Model (CAPM) provides a parsimonious method for estimating security returns. However, the strong influence of mining shares on the Johannesburg Stock Exchange (JSE) has complicated the use of the CAPM in South Africa and some researchers have suggested that broad sectoral indices should be used as market proxies in place of the JSE Actuaries All Share Index. This calls for the use of more complex, multi-parameter models, such as those derived from Arbitrage Pricing Theory (APT). This paper uses a multivariate graphical technique, correspondence analysis, to view the underlying structure of risk in the sectors of the JSE, It identifies three main groupings of the sectors; (1) precious metals and minerals, (2) other metals and minerals, and (3) industrial and financial shares. The CAPM, using the All Share Index as market proxy, is found to be an acceptable model for both mining and industrial shares. The Industrial and Financial index as market proxy does not define the maj.
Spinal cord compression studies. II. Time limits for recovery after acute compression in dogs.

IT IS CLINICALLY important to determine how long the spinal cord may be compressed without precluding functional recovery, because it would lead to more rational and standardized treatment. One would expect the time to be short because of the vulnerability of nerve tissue to mechanical distortion and anoxia. Allen* attempted to answer this question by producing contusion of the spinal cord of dogs. His technique was to drop known weights from known heights on the spinal cord. The degree of the impact was measured in gram-centimeters. Allen believed that the edema following the impact reached its maximum about four hours after the injury. He concluded that if the spinal cord compression caused by the edema could be prevented, the spinal cord might recover some function. Accordingly, he advised midline posterior incision of the spinal cord through the contused segment to drain and release the intramedullary pressure. He made such incisions
Investigating retrospective interoperability between the accessible and mobile webs with regard to user input

The World Wide Web (Web) has become a key technology to provide access to on-line information. The Mobile Web users, who access the Web using small devices such as mobile phones and Personal Digital Assistants (PDAs), make errors on entering text and controlling cursors. These errors are caused by both the characteristics of a device and the environment in which it is used, and are called situational impairments. Disabled Web users, on the other hand, have difficulties in accessing the Web due to their impairments in visual, hearing or motor abilities. We assert that errors experienced by the Mobile Web users share similarity in scope with those hindering motor-impaired Web users with dexterity issues, and existing solutions from the motor-impaired users domain can be migrated to the Mobile Web domain to address the common errors.Results of a systematic literature survey have revealed 12 error types that affect both the Mobile Web users and disabled Web users. These errors range from unable to locate a key to unable to pin-point a cursor. User experiments have confirmed that the Mobile Web users and motor-impaired Web users share errors in scope: they both miss key presses, press additional keys, unintentionally press a key more than once or press a key too long. In addition, both small device users and motor-impaired desktop users have difficulties in performing clicking, multiple clicking and drag selecting. Furthermore, when small device users are moving, both the scope and the magnitude of the errors are shared. In order to address these errors, we have migrated existing solutions from the disabled Web users domain into the Mobile Web users domain. We have developed a typing error correction system for the Mobile Web users. Results of the user evaluation have indicated that the proposed system can significantly reduce the error rates of the Mobile Web users.This work has an important contribution to both the Web accessibility field and the Mobile Web field. By leveraging research from the Web accessibility field into the Mobile Web field, we have linked two disjoint domains together. We have migrated solutions from one domain to another, and thus have improved the usability and accessibility of the Mobile Web.
PROMOTER OWNERSHIP AND CORPORATE LEVERAGE: EVIDENCE FROM INDIAN FIRMS

A higher level of debt may help in aligning the interests of managers and shareholders; however, managers may underestimate the resulting costs of bankruptcy. Moreover, notwithstanding the tax and other benefits of debt, literature shows that firms may have more debt in their capital structure than is appropriate. A higher level of leverage becomes detrimental by increasing the chances of financial distress and, consequently, the chances of bankruptcy. This study investigated relationships between changes in promoter ownership and changes in leverage by taking a sample of 322 Indian service and manufacturing firms from Top 500 Companies listed on the Bombay Stock Exchange (BSE) for a period of five years (from 2010-2014). The results indicate that changes in promoter ownership play a role in lowering the leverage of Indian firms and, consequently, reducing the chances of bankruptcy. The findings of this study also indicate that changes in promoter ownership have more effect on the leverage of Indian service firms as compared to manufacturing firms. This study contributes to the literature on the factors that affect the leverage of the firm. The findings may be useful for financial managers, investors, financial management consultants, and other stakeholders.