Miracle-dz/UniFAR-FTUs huggingface dataset:
Multivessel coronary revascularization and outcomes in kidney transplant recipients

Coronary artery disease is a major cause of morbidity and mortality in the kidney transplant population. We compared the long‐term outcomes of coronary artery bypass graft (CABG) surgery with percutaneous coronary intervention (PCI) for multivessel coronary disease in a contemporary cohort of US kidney transplant recipients. From the U.S. Renal Data System, we identified all adult kidney transplant patients with ≥6 months of Medicare A+B undergoing first recorded multivessel coronary revascularization from 1997 to 2009. The associations of CABG versus PCI with death and the composite of death or myocardial infarction (MI) were compared using proportional hazards regression. Of the 2272 patients included in the study, 1594 underwent CABG and 678 underwent PCI. The estimated 5‐year survival rate was 55% [95% confidence interval (CI) 53% to 57%] following coronary revascularization, with no significant association between revascularization type and death [adjusted hazard ratio (aHR) = 1.08; CI 0.94–1.23] or the composite of death or MI (aHR = 1.07; CI 0.96–1.18). Separate propensity score‐matched analyses yielded similar results. In this analysis of kidney transplant recipients undergoing multivessel coronary revascularization, we found no difference between CABG and PCI in terms of survival or the composite of death and MI.
Outcomes of Spinal Fusion in Children With Congenital Heart Disease

Background The children with congenital heart disease (CHD) have an increased risk of developing scoliosis. Many children with CHD may benefit from surgical intervention for scoliosis. However, there is uncertainty about the safety of spinal fusion in children with heart disease. The purpose of this study is to assess whether spinal fusion is safe and effective for children who have CHD. Methods We reviewed all the cases of children with CHD undergoing first-time spinal fusion for spinal deformity at Mayo Clinic between August 1976 and June 2008. Data were abstracted regarding cardiac history, major Cobb angle, type of spinal fusion (anterior, posterior, or both), intraoperative and postoperative complications, mortality, and follow-up. Results Sixty-four children under the age of 18 (64% female patients; mean age=11.5 y) were included in the study. The most common types of CHD were pulmonary atresia with ventricular septal defect and tetralogy of Fallot. Sixty-three percent of all patients had had prior cardiac surgery; 22% were cyanotic at the time of spinal fusion. Nine patients had single-ventricle physiology; 5 of whom had had Fontan palliation. Nine patients had pulmonary hypertension. Posterior fusion alone was carried out for 69% of the patients. Spinal instrumentation was used in 70% of cases. Average anesthesia time was 7.3 hours. Mean hospital stay was 9 days. Eighteen children (30%) required prolonged intubation of 1 day or longer. Prolonged intubation was more common in patients with a larger Cobb angle and in patients with pulmonary hypertension. Postoperative complications occurred in 27% of all patients and were more common in the patients with pulmonary hypertension. One child died postoperatively from a hemorrhage because of an arterial-esophageal fistula unrelated to her spinal fusion. Conclusions Spinal fusion in children with CHD is generally safe and effective. Children with pulmonary hypertension are at higher risk for complications from spinal fusion. Level of Evidence Level IV—Case Series.
Tactons: Structured Tactile Messages for Non-Visual Information Display

Tactile displays are now becoming available in a form that can be easily used in a user interface. This paper describes a new form of tactile output. Tactons, or tactile icons, are structured, abstract messages that can be used to communicate messages non-visually. A range of different parameters can be used for Tacton construction including: frequency, amplitude and duration of a tactile pulse, plus other parameters such as rhythm and location. Tactons have the potential to improve interaction in a range of different areas, particularly where the visual display is overloaded, limited in size or not available, such as interfaces for blind people or in mobile and wearable devices. This paper describes Tactons, the parameters used to construct them and some possible ways to design them. Examples of where Tactons might prove useful in user interfaces are given.
Scientific Proceedings-Panel Reports: Presentation of Clinical Experience

LuhfPNER reviewed the work of the Committee on Scientific ActivK ities that led to recommendations for ,reporting psychoanalytic cases. The impression of paucity of clinical data in our literature was confirmed in a review of the 15 most cited psychoanalytic articles from 1969 to 1982. They contain no significant primary clinical data. Most were general statements of clinical observations, experience, or reflections. The most frequent descriptions of the papers included “no clinical data,” ‘(no evidence,” “overgeneralized,” or “untestable assumptions. ” It was as if the facts were known-the issue, interpretation, not documentation. Case reports communicate clinical findings most compellingly. Details help readers understand the psychic reality of the clinical event. Retrospective analysis of events requires detailed information about patient-analyst communication which helps us resonate with the reporting analysts’ experience. In coming to its recommendations the Committee discussed many problems. Most analytic data are gathered retrospectively. Process notes seem to present primary data, but rarely-do. Even when material appears verbatim it is often unclear how much is selected or revised. The reader has little chance to make direct contact with the clinical data to reach his own conclusions. Observation is confiated with inference. Undue reliance on narrative and brief vignettes obscures analytic experience and supports received theory. Lack of detailed clinical descriptions makes alternative understanding difficult. Analysts are trained to tolerate ambiguity and generate various accounts of clinical events. Narratives sparse in detail interfere withthe reader’s use of this training to compare his thinking with the author’s.
Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments

ZO-1, a 220-kD peripheral membrane protein consisting of an amino-terminal half discs large (dlg)-like domain and a carboxyl-terminal half domain, is concentrated at the cadherin-based cell adhesion sites in non-epithelial cells. We introduced cDNAs encoding the full-length ZO-1, its amino-terminal half (N-ZO-1), and carboxyl-terminal half (C-ZO-1) into mouse L fibroblasts expressing exogenous E-cadherin (EL cells). The full-length ZO-1 as well as N-ZO-1 were concentrated at cadherin-based cell–cell adhesion sites. In good agreement with these observations, N-ZO-1 was specifically coimmunoprecipitated from EL transfectants expressing N-ZO-1 (NZ-EL cells) with the E-cadherin/α, β catenin complex. In contrast, C-ZO-1 was localized along actin stress fibers. To examine the molecular basis of the behavior of these truncated ZO-1 molecules, N-ZO-1 and C-ZO-1 were produced in insect Sf9 cells by recombinant baculovirus infection, and their direct binding ability to the cadherin/catenin complex and the actin-based cytoskeleton, respectively, were examined in vitro. Recombinant N-ZO-1 bound directly to the glutathione-S-transferase fusion protein with α catenin, but not to that with β catenin or the cytoplasmic domain of E-cadherin. The dissociation constant between N-ZO-1 and α catenin was ∼0.5 nM. On the other hand, recombinant C-ZO-1 was specifically cosedimented with actin filaments in vitro with a dissociation constant of ∼10 nM. Finally, we compared the cadherin-based cell adhesion activity of NZ-EL cells with that of parent EL cells. Cell aggregation assay revealed no significant differences among these cells, but the cadherin-dependent intercellular motility, i.e., the cell movement in a confluent monolayer, was significantly suppressed in NZ-EL cells. We conclude that in nonepithelial cells, ZO-1 works as a cross-linker between cadherin/catenin complex and the actin-based cytoskeleton through direct interaction with α catenin and actin filaments at its amino- and carboxyl-terminal halves, respectively, and that ZO-1 is a functional component in the cadherin-based cell adhesion system.
Perturbations in Action Goal Influence Bimanual Grasp Posture Planning

ABSTRACT The authors examined the effects of perturbations in action goal on bimanual grasp posture planning. Sixteen participants simultaneously reached for 2 cylinders and placed either the left or the right end of the cylinders into targets. As soon as the participants began their reaching movements, a secondary stimulus was triggered, which indicated whether the intended action goal for the left or right hand had changed. Overall, the tendency for a single hand to select end-state comfort compliant grasp postures was higher for the nonperturbed condition compared to both the perturbed left and perturbed right conditions. Furthermore, participants were more likely to plan their movements to ensure end-state comfort for both hands during nonperturbed trials, than perturbed trials, especially object end-orientation conditions that required the adoption of at least one underhand grasp posture to satisfy bimanual end-state comfort. Results indicated that when the action goal of a single object was perturbed, participants attempted to reduce the cognitive costs associated with grasp posture replanning by maintaining the original grasp posture plan, and tolerating grasp postures that result in less controllable final postures.
Exploiting the Physical Environment for Securing the Internet of Things

Using the randomness provided by the physical environment to build security solutions has received much attention recently. In particular, the shared entropy provided by measuring ambient audio, luminosity modalities or electromagnetic emanations has been used to build location-based, proximity-based, or context-based security mechanisms. The majority of those protocols is based on a standard model consisting channel probing, quantization, information reconciliation, privacy amplification, and key verification. The main problem for almost all approaches is the limited understanding of the security that is provided. For example, security analyses often only address single components and not the entire system or are based on broad abstractions of the physical source of randomness. Further, a big open question is the feasibility of such systems for low-resource platforms. Our first contribution is a detailed, optimized realization of a key establishment system. We demonstrate the feasibility of deriving a shared secret from correlated quantities on resource-constrained devices with tight power budget. Our system was realized on the popular ARM Cortex-M3 processor that reports detailed resource requirements. The second major contribution is a summary and abstraction of previous works together with a rigorous security analysis. We substantiate our investigation by presenting practical attack results.
Neuromagnetic brain activities associated with perceptual categorization and sound-content incongruency: a comparison between monosyllabic words and pitch names

In human cultures, the perceptual categorization of musical pitches relies on pitch-naming systems. A sung pitch name concurrently holds the information of fundamental frequency and pitch name. These two aspects may be either congruent or incongruent with regard to pitch categorization. The present study aimed to compare the neuromagnetic responses to musical and verbal stimuli for congruency judgments, for example a congruent pair for the pitch C4 sung with the pitch name do in a C-major context (the pitch-semantic task) or for the meaning of a word to match the speaker’s identity (the voice-semantic task). Both the behavioral data and neuromagnetic data showed that congruency detection of the speaker’s identity and word meaning was slower than that of the pitch and pitch name. Congruency effects of musical stimuli revealed that pitch categorization and semantic processing of pitch information were associated with P2m and N400m, respectively. For verbal stimuli, P2m and N400m did not show any congruency effect. In both the pitch-semantic task and the voice-semantic task, we found that incongruent stimuli evoked stronger slow waves with the latency of 500–600 ms than congruent stimuli. These findings shed new light on the neural mechanisms underlying pitch-naming processes.
Frontiers in Computational Neuroscience Enabling Functional Neural Circuit Simulations with Distributed Computing of Neuromodulated Plasticity

many brain areas through long range connections (for a review see Cooper et al., 2002). The functional consequences of the long-range neuromodulatory projections are very diverse and depend strongly on the specific neuromodulator, the target area and the neuromodulatory concentration. For example, the release of ace-tylcholine from the basal forebrain into the cortex is involved in the and noradrenaline, mainly originating from the locus coeruleus, is released throughout the central nervous system facilitating the processing of relevant, or salient, information (Berridge and Waterhouse, 2003). One neuromodula-tory function which has evoked high interest in the experimental as well as the theoretical neuroscience communities is reward learning on the basis of dopamine released in the striatum from midbrain areas (Schultz et al., 1997; Reynolds et al., 2001). An influential hypothesis on the mechanism of neuromodu-lation is that neuromodulators can be released extrasynaptically from en passant boutons on neuromodulatory axons and modulate the plasticity of synapses that are remote from release sites, a concept known as volume transmission (Agnati et al., 1995; 1 IntroductIon It is generally assumed that mammalian learning is implemented by changes in synaptic efficacy, as it is the case in simpler organisms (see e.g., Antonov et al., 2003). Historically, attempts to provide a theoretical explanation of learning have mainly been influenced by Hebb's postulate (Hebb, 1949) that the sequential activation of two neurons strengthens the synapse connecting them. Thus, theoretical " Hebbian " plasticity rules depend on the pre-and post-synaptic activity and sometimes also on the weight itself. Although these rules have been shown to solve some interesting problems it is not clear that such " two factor " rules can be the mechanism that enables animals to learn complicated tasks, such as those to find sparse rewards in complex environments. However, experiments have shown that in some preparations, synaptic plasticity depends not only on the activity of the pre-and post-synaptic neurons but also on the presence of neuromodulators such as acetylcholine, norepinephrine, serotonin, and dopamine. Neuromodulators are released from neurons that are primarily located in the brainstem and basal forebrain, but that innervate A major puzzle in the field of computational neuroscience is how to relate system-level learning in higher organisms to synaptic plasticity. Recently, plasticity rules depending not only on pre-and post-synaptic activity but also on a third, non-local neuromodulatory signal have emerged as key candidates to bridge the gap between the macroscopic and the microscopic level …
Constructing good learners using evolved pattern generators

Self-organization of brain areas in animals begins prenatally, evidently driven by spontaneously generated internal patterns. The neural structures continue to develop postnatally when the sensory systems are exposed to stimuli from the environment. In this process, prenatal training may give the neural system the appropriate bias so that it can learn reliably under changing environmental stimuli. This paper evaluates the hypothesis that an artificial learning system can benefit from a similar approach, consisting of initial training with patterns from an evolved generator followed by training with the actual training set. Competitive learning networks were trained in recognizing handwritten digits in three ways: through environmental learning only, through evolution only, and through prenatal training with evolved pattern generators followed by environmental learning. The results demonstrate that the evolved pattern generator approach leads to better learning performance, suggesting that complex systems can be constructed effectively in this way.
Immunization of Cattle with Tick Salivary Gland Extracts

Background: Rhipicephalus (Boophilus) annulatus tick is one of the most important ectoparasite of cattle. Recently, several laboratories in the world have been concentrated on immunizing cattle against tick using various types of tissue extracts of ticks. The aim of this study was to evaluate the effect of immunization of cattle with tick salivary gland extract on biological parameters of ticks and humoral immune responses of cattle. Methods: Fourteen more dominant protein bands identified as immunogenic by Western-blot analysis were eluted from polyacrylamide gel. Test and control groups were injected three times with eluted proteins and sterile PBS (pH= 7.2) respectively with equivalent amount of adjuvant. After four weeks a tick challenge was performed. Finally, biological parameters of collected engorged female ticks were recorded and humoral immune responses to immunization measured by ELISA. Results: The results indicated immunization of cattle resulted in reduction in mean tick counts, attachment, engorgement weights, feeding index, egg mass weight, hatchability and fertility index (respectively 63.1%, 62.6%, 30.2%, 36.4%, 40%, 78.7% and 13.3%) and increased duration of feeding, preoviposition and incubation period of eggs (respectively 8.6%, 45 and 31.34%). All changes were statistically significant (P< 0.05). Results showed an increase in antibody production of test group from the first week after immunization. The antibody level was boosted following tick infestation. Conclusion: This investigation indicates that immunization of cattle with these antigens could induce a protective immune response against Rh. (B.) annulatus tick that would be expected to provide a safe non-chemical means of tick control.
Business rules design method for Business Process Management

The paper deals with the problem of designing business rules (BR) for the business process modeling (BPM). It shows the role of knowledge in BPMand points out the issues that arise from the link between knowledge and the BPM. It presents the challenges of BR modeling, shows some disadvantages of existing and commonly used methods. As a solution, a method based on the XTT approach is outlined and discussed.
Skin lesion analysis system for melanoma detection with an effective hair segmentation method

Skin cancer is one of the most challenging disease among various cancer type. According to the studies, there are different types of skin cancers like melanoma, basal cell carcinoma (BCC), and squamous cell carci- noma (SCC). Melanoma is a condition where the production of melanin is significantly reduced because of the dysfunctionality of melanocyte cells. One of the major factor that affects the melanocyte cell is sunburn due to the ultraviolet rays from the sun. The disorder can be identified by the shape, color and texture of skin lesion. The skin lesion can be normally separated into three as benign, atypical and melanoma. A benign skin lesion is a normal skin, atypical skin lesion may or may not be cancerous and melanoma is surely a cancerous one. This paper proposes a non invasive automated skin lesion analysis system for the early detection of melanoma using image processing techniques and mobile technologies. Hair detection and removal is performed for effective classification and extraction features of the skin wound. A fast marching in painting algorithm is used for the hair removal.
Structure and transcription analysis of the gene encoding a cellobiase from Agrobacterium sp. strain ATCC 21400

The DNA sequence was determined for the cloned Agrobacterium sp. strain ATCC 21400 beta-glucosidase gene, abg. High-resolution nuclease S1 protection studies were used to map the abg mRNA 5' and 3' termini. A putative abg promoter was identified whose sequence shows similarities to the consensus promoter of Escherichia coli and with the nif promoter regions of Klebsiella. The abg coding sequence was 1,374 nucleotides long. The molecular weight of the enzyme, based on the predicted amino acid sequence, was 51,000. The observed Mr was 50,000 to 52,000. A region of deduced protein sequence was homologous to a region from two other beta-glucosidase sequences. This region of homology contained a putative active site by analogy with the active site of hen egg white lysozyme.
ADOLESCENTS' COMPREHENSION AND CONTENT AREA EDUCATION STUDENTS' PERCEPTIONS: BENEFITS FROM ONE-ON-ONE TUTORING

In this research study the authors analyzed the effectiveness of content-area education students tutoring adolescents and documented changes in the attitudes of the education students over time. Tutors tested the reading comprehension of both the students they tutored (treatment group) and students they did not (comparison group). The authors used a repeated measures ANOVA to evaluate the effects of the tutorial program on reading for the two groups. The dependent variable was pre- and post-reading scores as measured by the Bader Reading & Language Inventory for both groups. The main effect was significant for the tutored group. In addition, the authors utilized the “preservice teachers' perception/attitude survey” using a Likert scale to document changes in the attitudes of the education students toward implementing literacy strategies within their content areas. To test the effects of the semester-long experience, the authors employed a repeated measures ANOVA to determine significance between the pre/post means. The authors' findings revealed that the semester's experience had a significant impact on the tutors' attitude mean; however, no significant differences pre to post were found among the various content majors.
Social networks and identity negotiations of religious minority youth in diverse social contexts

Abstract This study is looking at how youth growing up in families affiliated with a religious minority negotiate their religious values and social identity in the social contexts of minority and majority. Although these youth belong to the ethnic majority in Finland, the religious and lifestyle values of their home and religious community differ from the Lutheran mainstream, which causes discrepancies between the values of their socialization background and those of their peer group. The negotiations of values and identities are here examined through two case examples of the teenagers' interview data. These examples illustrate the varied strategies for negotiation, positive versus negative experiences on the acquired negotiation outcomes, as well as the diversity within a minority community and the different ways of being a member of a religious minority.