Miracle-dz/UniFAR-FTUs huggingface dataset:
The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34

The herpes simplex virus (HSV) virulence factor ICP34.5, the mouse myeloid differentiation protein MyD116, and the hamster growth arrest and DNA damage protein GADD34 share a 63-amino-acid carboxyl domain which has significant homologies to otherwise divergent proteins. Here we report that both ICP34.5 and its cellular homolog MyD116 complex through the conserved domain with proliferating cell nuclear antigen. In addition, HSV infection induces a novel 70-kDa cellular protein detectable by antisera to both ICP34.5 and GADD34, demonstrating that this novel protein possesses homology with the 63-amino-acid conserved domain.
Localization of brain activity by temporal anti-correlation with the posterior cingulate cortex

The default mode network of brain function hypothesis has recently attracted more attention in the neuro- science community. In this study, we addressed a new data- driven method that based on temporal anti-correlation with the posterior cingulate cortex, one node of the default mode network, to localize the brain activation related to task and spontaneous epileptic discharges. The experimental results of real fMRI data analysis show not only the task-related activation region can be robustly recognized without any prior information on the functional activation paradigm, but also the epileptogenic zone in some patients with frequent interictal epileptiform discharges can be localized reliably using resting- state fMRI without EEG.
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer.

PURPOSE To report the long-term results of the Intergroup Radiation Therapy Oncology Group 91-11 study evaluating the contribution of chemotherapy added to radiation therapy (RT) for larynx preservation. PATIENTS AND METHODS Patients with stage III or IV glottic or supraglottic squamous cell cancer were randomly assigned to induction cisplatin/fluorouracil (PF) followed by RT (control arm), concomitant cisplatin/RT, or RT alone. The composite end point of laryngectomy-free survival (LFS) was the primary end point. RESULTS Five hundred twenty patients were analyzed. Median follow-up for surviving patients is 10.8 years. Both chemotherapy regimens significantly improved LFS compared with RT alone (induction chemotherapy v RT alone: hazard ratio [HR], 0.75; 95% CI, 0.59 to 0.95; P = .02; concomitant chemotherapy v RT alone: HR, 0.78; 95% CI, 0.78 to 0.98; P = .03). Overall survival did not differ significantly, although there was a possibility of worse outcome with concomitant relative to induction chemotherapy (HR, 1.25; 95% CI, 0.98 to 1.61; P = .08). Concomitant cisplatin/RT significantly improved the larynx preservation rate over induction PF followed by RT (HR, 0.58; 95% CI, 0.37 to 0.89; P = .0050) and over RT alone (P < .001), whereas induction PF followed by RT was not better than treatment with RT alone (HR, 1.26; 95% CI, 0.88 to 1.82; P = .35). No difference in late effects was detected, but deaths not attributed to larynx cancer or treatment were higher with concomitant chemotherapy (30.8% v 20.8% with induction chemotherapy and 16.9% with RT alone). CONCLUSION These 10-year results show that induction PF followed by RT and concomitant cisplatin/RT show similar efficacy for the composite end point of LFS. Locoregional control and larynx preservation were significantly improved with concomitant cisplatin/RT compared with the induction arm or RT alone. New strategies that improve organ preservation and function with less morbidity are needed.
A hybrid metric for camera pose estimation in RGB-D reconstruction

In this paper, we propose a hybrid metric for measuring the accuracy of the estimated camera. Existing camera pose evaluation methods are mainly built upon one of the two metrics: the geometric measurement or the photometric measurement. The geometric based method inspects the relative position between source and target points, while the photometric based method utilizes the pixel intensity as assessment. The proposed hybrid metric is represented by a vector containing both the geometric measurement and the photometric measurement. The optimal transform between a pair of frames can be found by minimizing the hybrid metric between the two frames. Based on the proposed hybrid metric, we propose an outlier removal algorithm for finding the pose outliers, and a pose estimation algorithm for estimating the camera pose. Experimental results demonstrated that the proposed hybrid metric outperforms the geometric based metric and photometric based metric in terms of the accuracy of outlier identification and camera pose estimation.
Host–microbiome interactions in human type 2 diabetes following prebiotic fibre (galacto-oligosaccharide) intake

Abstract Aberrant microbiota composition and function have been linked to several pathologies, including type 2 diabetes. In animal models, prebiotics induce favourable changes in the intestinal microbiota, intestinal permeability (IP) and endotoxaemia, which are linked to concurrent improvement in glucose tolerance. This is the first study to investigate the link between IP, glucose tolerance and intestinal bacteria in human type 2 diabetes. In all, twenty-nine men with well-controlled type 2 diabetes were randomised to a prebiotic (galacto-oligosaccharide mixture) or placebo (maltodextrin) supplement (5·5 g/d for 12 weeks). Intestinal microbial community structure, IP, endotoxaemia, inflammatory markers and glucose tolerance were assessed at baseline and post intervention. IP was estimated by the urinary recovery of oral 51Cr-EDTA and glucose tolerance by insulin-modified intravenous glucose tolerance test. Intestinal microbial community analysis was performed by high-throughput next-generation sequencing of 16S rRNA amplicons and quantitative PCR. Prebiotic fibre supplementation had no significant effects on clinical outcomes or bacterial abundances compared with placebo; however, changes in the bacterial family Veillonellaceae correlated inversely with changes in glucose response and IL-6 levels (r −0·90, P=0·042 for both) following prebiotic intake. The absence of significant changes to the microbial community structure at a prebiotic dosage/length of supplementation shown to be effective in healthy individuals is an important finding. We propose that concurrent metformin treatment and the high heterogeneity of human type 2 diabetes may have played a significant role. The current study does not provide evidence for the role of prebiotics in the treatment of type 2 diabetes.
Achieving Success in NPD Projects T

The new product development (NPD) literature emphasizes the importance of introducing new products on the market for continuing business success. New products are responsible for employment, economic growth, technological progress, and high standards of living. Therefore, the study of NPD and the processes through which they emerge is important. The goal of our research is to propose a framework of critical success factors, metrics, and tools and techniques for implementing metrics for each stage of the new product development (NPD) process. An extensive literature review was undertaken to investigate decades of studies on NPD success and how it can be achieved. These studies were scanned for common factors for firms that enjoyed success of new products on the market. The paper summarizes NPD success factors, suggests metrics that should be used to measure these factors, and proposes tools and techniques to make use of these metrics. This was done for each stage of the NPD process, and brought together in a framework that the authors propose should be followed for complex NPD projects. While many studies have been conducted on critical success factors for NPD, these studies tend to be fragmented and focus on one or a few phases of the NPD process. Keywords—New product development, performance, critical success factors, framework.
Improved multicanonical algorithm for outage probability estimation in MIMO channels

Multicanonical Monte Carlo (MMC) is an adaptive importance sampling technique which employs a blind adaptation algorithm to converge to the optimal biasing distribution. In this paper, we propose an improved MMC algorithm for fast estimation of outage probabilities in Multiple Input Multiple Output (MIMO) channels. The algorithm uses an improved estimator which can provide smooth estimates with high reliability at very low error probabilities. The proposed estimator uses moving average filtering to smooth the visits histograms at each iteration thereby reducing the stochastic fluctuations between iterations. We compare the proposed estimator with the well known Berg's update and the simulation results show that the new estimator can accurately estimate lower error probabilities with the same number of samples.
Developing indigenous knowledge databases in India

Purpose – The paper seeks to reflect the information environment with emphasis on indigenous science and technology knowledge requirement in developing countries, particularly India.Design/methodology/approach – Indigenous scientific/technical knowledge functions as a critical national resource for any developing country. Literature reflects need and provision of database services that can cater to indigenous knowledge.Findings – The paper discusses nationally developed databases, various aspects related to initiation and creation of these databases in India. The objectives behind development of such databases and some factors such as indigenous knowledge need, strategic culture, managerial capability, technological thrust and organizational interest responsible for developing databases in India are highlighted. Other features such as quality assessment control and network‐based indigenous knowledge database access and information delivery are discussed. Current indigenous knowledge database activities, e.
Delayed Osteotomy but Not Fracture Healing in Pediatric Osteogenesis Imperfecta Patients Receiving Pamidronate

This study evaluated factors influencing fracture (n = 197) and osteotomy (n = 200) healing in children with moderate to severe OI. Pamidronate treatment was associated with delayed healing after osteotomy, but not after fracture. The data suggest that both pamidronate and mechanical factors influence bone healing in this cohort.
Operating characteristics of a rank correlation test for publication bias.

An adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations. The test statistic is a direct statistical analogue of the popular "funnel-graph. " The number of component studies in the meta-analysis, the nature of the selection mechanism, the range of variances of the effect size estimates, and the true underlying effect size are all observed to be influential in determining the power of the test. The test is fairly powerful for large meta-analyses with 75 component studies, but has only moderate power for meta-analyses with 25 component studies. However, in many of the configurations in which there is low power, there is also relatively little bias in the summary effect size estimate. Nonetheless, the test must be interpreted with caution in small meta-analyses. In particular, bias cannot be ruled out if the test is not significant. The proposed technique has potential utility as an exploratory tool for meta-analysts, as a formal procedure to complement the funnel-graph.
Protection Design for a 10-T HTS Insert Magnet

The NOUGAT project is the first step toward a 30-T all-superconducting high-field magnet. It combines a 20-T resistive outsert, which is one of the test facilities in the National Laboratory for Intense Magnetic Fields (LNCMI), and a 10-T high-temperature superconductor (HTS) insert. After a brief presentation of the HTS insert, we detail the protection principle that is based on the extraction of the energy simultaneously in a discharge resistance and in copper rings located within the insert. The main role of these rings is to act as a transformer secondary and to dissipate a large fraction of the energy during the discharge. We show that this energy dissipation is not significant enough to consider the rings as passive heaters due to the large temperature margins within the HTS insert. Analytical calculations have also been led on a simple two-loop circuit, and criteria regarding the flux linkage and mutual coupling have been defined to check the efficiency of the protection principle.
Fundamental issues of implementing hardware neural networks using memristor

This paper presents critical issues of memristor degrading the performance of neuromorphic system. Among possible defects of memristor, problems of sneak path and weight retention are critical for performance of memristive neuromorphic system. To solve these inherent problems, specific methods are introduced, and consequently, it is suggested that the memristor which satisfies the specification required in system is essential.
A Phospholipase D-dependent Process Forms Lipid Droplets Containing Caveolin, Adipocyte Differentiation-related Protein, and Vimentin in a Cell-free System*

We developed a microsome-based, cell-free system that assembles newly formed triglyceride (TG) into spherical lipid droplets. These droplets were recovered in the d ≤ 1.055 g/ml fraction by gradient ultracentrifugation and were similar in size and appearance to those isolated from rat adipocytes and 3T3-L1 cells. Caveolin 1 and 2, vimentin, adipocyte differentiation-related protein, and the 78-kDa glucose regulatory protein were identified on the droplets from the cell-free system. The caveolin was soluble in 1% Triton X-100, as was the caveolin on lipid droplets from 3T3-L1 cells. The lipid droplets from the cell-free system, like those from 3T3-L1 cells, contained TG, diacylglycerol, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine. The assembly of these TG-containing structures was dependent on the rate of TG biosynthesis and required an activator present in the 160,000 × g supernatant from homogenized rat adipocytes. The activator induced phospholipase D (PLD) activity, and its effect on the release of the TG-containing structures from the microsomes was inhibited by 1-butanol (but not 2-butanol) or 2,3-diphosphoglycerate. The activator could be replaced by a constitutively active PLD or phosphatidic acid. These results indicate that PLD and the formation of phosphatidic acid are important in the assembly of the TG-containing structures.
Problems for knowledge discovery in databases and their treatment in the statistics interpreter explora

In this article we describe some goals and problems of KDD. Approaches are presented which have been implemented in the Statistics Interpreter Explora, a prototype assistant system for discovering interesting findings in recurrent datasets. We introduce patterns to identify what is interesting in data and give some examples of patterns for difference‐, change‐, and trend‐detection. Then we summarize what must be specified to define a pattern. Besides some descriptive parts, this includes a procedural verification method. Object‐oriented programming techniques can simplify the specializations of general patterns. We identify search as a constituent principle of discovery and introduce object structures as a basis to induce a graph structure on the search space. We mention several strategies for graph search and describe approaches for dealing with the aggregation, redundancy, and overlapping problems. Then we address the presentation of findings in natural language and graphical form, focusing on the methods to design good graphical presentations by knowledge‐based techniques. Finally, we discuss the paradigm of an adaptive discovery assistant, including the problem of how to reuse the discovered knowledge for further discovery. © 1992 John Wiley & Sons, Inc.
Maintenance of views

In relational databases a view definition is a query against the database, and a view materialization is the result of applying the view definition to the current database A view materialization over a database may change as relations in the database undergo modificationsIn this paper a mechanism is proposed in which the view is materialized at all times The problem which this mechanism addresses is how to quickly update the view in response to database changes A structure is maintained which provides information useful in minimizing the amount of work caused by updatesMethods are presented for handling both general databases and the much simpler tree databases (also called acyclic database) In both cases adding or deleting a tuple can be performed in polynomial time For tree databases the degree of the polynomial is independent of the schema structure while for cyclic databases the degree depends on the schema structure The cost of a sequence of tuple additions (deletions) is also analyzed
Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations inBRCA1

While sequence analysis is considered by many to be the most sensitive method of detecting unknown mutations in large genes such asBRCA1, most published estimates of the prevalence of mutations in this gene have been derived from studies that have used other methods of gene analysis. In order to determine the relative sensitivity of techniques that are widely used in research on BRCA1, a set of blinded samples containing 58 distinct mutations were analysed by four separate laboratories. Each used one of the following methods: single strand conformational polymorphism analysis (SSCP), conformation sensitive gel electrophoresis (CSGE), two dimensional gene scanning (TDGS), and denaturing high performance liquid chromatography (DHPLC). Only the laboratory using DHPLC correctly identified each of the mutations. The laboratory using TDGS correctly identified 91% of the mutations but produced three apparent false positive results. The laboratories using SSCP and CSGE detected abnormal migration for 72% and 76% of the mutations, respectively, but subsequently confirmed and reported only 65% and 60% of mutations, respectively. False negatives therefore resulted not only from failure of the techniques to distinguish wild type from mutant, but also from failure to confirm the mutation by sequence analysis as well as from human errors leading to misreporting of results. These findings characterise sources of error in commonly used methods of mutation detection that should be addressed by laboratories using these methods. Based upon sources of error identified in this comparison, it is likely that mutations inBRCA1 and BRCA2are more prevalent than some studies have previously reported. The findings of this comparison provide a basis for interpreting studies of mutations in susceptibility genes across many inherited cancer syndromes.
RESEARCH ARTICLE Automatic Evaluation of Design Alternatives with Quantitative Argumentation

This paper presents a novel argumentation framework to support IBIS-style debates on design alternatives, by providing an automatic quantitative evaluation of the positions put forwards. It also identies several formal properties of the proposed quantitative argumentation frame- work and compares it with existing non-numerical abstract argumentation formalisms. Finally, the paper describes the integration of the proposed approach within the designVUE software tool along with three case studies in engineering design. The case studies show the poten- tial for a competitive advantage of the proposed approach with respect to state-of-the-art engineering design methods. Engineering design is often described as an information-processing activity based on problem solving within the constraints of bounded rationality (Simon 1996, Si- mon and Newell 1971). It consists of decomposing an initial problem into a range of sub-problems, proposing and assessing partial solutions, and integrating them as to satisfy the overall problem. This process is collaborative and often involves communication between non co-located engineers. The development and commu- nication of design solutions require engineers to form and share design rationale, i.e. the argumentation in favour or against proposed designs. These aspects of the engineering design process have led to the develop- ment (Kunz and Rittel 1970) and subsequent investigation (Buckingham Shum and Hammond 1994, Fischer et al. 1991) of the Issue Based Information System (IBIS) method, a graph-based formalisation of the decisions made during a design process along with the reasons why they were made. The IBIS method envisions a decision-making process where problems (or issues) are given solutions (or an- swers) after a thorough debate involving technical, economical, life, environmental and safety considerations. It also provides means to actively develop, communicate and record the reasons (or arguments) in favour or against the options explored during the design process. Initially, IBIS has been conceived purely as a conceptual
Gaze-shift patterns of young children with developmental disabilities who are at risk for being nonspeaking

Children with developmental disabilities often have difficulty with joint attention that can affect more advanced communication skills. This study evaluated the complexity of child engagement behaviors demonstrated by twenty-five pre-intentional children (age 9 to 25 months), who had developmental disabilities and were at risk for being nonspeaking. During free play with their parents, these children demonstrated infrequent and simple gaze shifts and focused more on individual objects or people than shared attention with parents during play. These children seldom engaged in coordinated attention behaviors such as shifting gaze back and forth between people and objects during their play with parents. Type and frequency of engagement behaviors are discussed relative to understanding the unique challenges for children with developmental disabilities that include motor and visual impairments. The quality of joint attention with adult partners has been found to influence the later communicative development in children with disabilities (Legerstee & Weintraub, 1997, Mundy & Willoughby, 1996, Yoder & Farran, 1986). Joint attention is defined as a state in which the attention of a caregiver and child are focused on the same object, typically demonstrated in early infancy through simple gaze shift patterns (Bakeman & Adamson, 1984). Joint attention allows a child to realize that meanings can be exchanged between people and suggests an understanding that social partners can serve an instrumental function. By six months of age, typically developing children begin to gaze shift between caregivers and objects (Bakeman & Adamson, 1984). Generally by thirteen months of age, children demonstrate three-point gaze shifts, coordinating their attention back and forth between a person and shared objects of attention (i.e. adult 3 toy 3 adult, or toy 3 adult 3 toy) (Bakeman & Adamson, 1984). With threepoint, “coordinated” joint attention, children can actively engage in or monitor activities jointly with partners, by sharing attention to an object or topic of interest. It is possible, but unclear, whether children engage in some two-point gaze shifts where they look only once at a person and an object at a time (i.e. adult 3 toy, or toy 3 adult) before they can engage in coordinated three-point joint atten-