Miracle-dz/UniFAR-FTUs huggingface dataset:
Does An MBA Help Women? : A Comparative Study Of The Career Progress And Labour Market Position Of Part Time Male And Female MBA Graduates

This thesis aims to assess the extent to which an MBA helps women and to ascertain whether significant barriers persist, despite their qualification to their career development. It takes as its frame of reference the sex difference approach within liberal feminism, which argues that key differences between men and women explain their differential career progress, and the organisation- structure approach within radical feminism which emphasises the detrimental effects of structural features of the organisation and of power relations. To this effect a survey of 221 male and female MBA graduates was conducted. Results suggest that the extent to which an MBA helps women depends on the type of benefit in question. The MBA is beneficial to women in terms of intrinsic career factors such as credibility and confidence. The qualification also gives them higher personal status within the context of the formal organisation. However, men appear to benefit more than women in terms of extrinsic career factors such as pay and management level in that they progress further in their careers subsequent to the MBA. In terms of the sex difference approach, differences in individual characteristics between men and women were not found to be sufficiently strong to be able to explain their differential career progress. Instead women MBAs were found to experience hidden barriers relating to attitudes and culture and to be particularly disadvantaged within the informal organisational context. The thesis argues that the way these hidden barriers located within the informal context impact on women's progress within the formal organisation (the informal externality effect) explains their slower career progress subsequent to the MBA in relation to men. The level of disadvantage within the formal context created by these hidden barriers are likely to be greater if the organisation is male dominated, if the gender imbalance occurs at senior levels and if women occupy traditionally female and non powerful roles.
The potential of proteasome inhibition in the treatment of colon cancer

Proteasome inhibition is an entirely novel approach to the treatment of malignant disease. By interfering with the ubiquitin–proteasome degradation system, proteasome inhibitors affect numerous cellular processes that are commonly deregulated in cancer cells including gene transcription, cell-cycle regulation, apoptosis, cell migration and DNA repair. This review outlines the physiology of the ubiquitin–proteasome pathway, discusses preclinical and clinical data regarding the activity of proteasome inhibitors against colon cancer and evaluates the rationale for the use of proteasome inhibitors as monotherapy or in combination with other anticancer therapies (i.e., chemotherapy, radiation therapy and other molecular-targeted therapies) in colon cancer.
Bayesian estimation with uncertain parameters of probability density functions

In this paper, we address the problem of processing imprecisely known probability density functions by means of Bayesian estimation. The imprecise knowledge about probability density functions is given as stochastic uncertainty about their parameters. The proposed processing of this special density in a Bayesian estimator is accomplished by reinterpretation of the filter and prediction equations. Here, the parameters are treated as a higher order state, which can be processed by Bayesian estimation techniques. For state estimation, this avoids the need to select specific values for unknown parameters and, thus, allows the processing of all potential parameters at once. The proposed approach further allows the use of imprecisely known model equations for measurement and state prediction by the same principle.
Crescent marketing, Muslim geographies and brand Islam: Reflections from the JIMA Senior Advisory Board

Purpose – The purpose of this paper is to bring together the thoughts and opinions of key members of the Journal of Islamic Marketing's (JIMA) Editorial Team, regarding the recently branded phenomenon of Islamic marketing – in the interests of stimulating further erudition.Design/methodology/approach – The authors adopted an “eagle eye” method to investigate this phenomenon: Where attempts were made to frame general principles and observations; alongside a swooping view of key anecdotal observations – in order to ground and enrich the study. The authors participated in an iterative process when analysing longitudinal and contemporary phenomenological data, in order to arrive at a consensus. This was grounded in: triangulating individual and collective researcher findings; critiquing relevant published material; and reflecting upon known reviewed manuscripts submitted to marketing publications – both successful and unsuccessful.Findings – The authors assert that a key milestone in the study and practice of.
Forklaringer på individuelle forskjeller i tilknytningsmønstre hos barn og voksne (Tidsskrift for Norsk Psykologforening)

Er det mulig a skille tilknytningsatferd fra temperament og personlighet? Ikke hvis tilknytning males med sporreskjemametoden i stedet for med intervju eller observasjon. Nar de ulike malene overlapper hverandre, avslores en tydeligere tendens til at tilknytning er pavirket av arv.
Enabling context-aware HTTP with mobile edge hint

Due to dynamic wireless network conditions and heterogeneous mobile web content complexities, web-based content services in mobile network environments always suffer from long loading time. The new HTTP/2.0 protocol only adopts one single TCP connection, but recent research reveals that in real mobile environments, web downloading using single connection will experience long idle time and low bandwidth utilization, in particular with dynamic network conditions and web page characteristics. In this paper, by leveraging the Mobile Edge Computing (MEC) technique, we present the framework of Mobile Edge Hint (MEH), in order to enhance mobile web downloading performances. Specifically, the mobile edge collects and caches the meta-data of frequently visited web pages and also keeps monitoring the network conditions. Upon receiving requests on these popular webpages, the MEC server is able to hint back to the HTTP/2.0 clients on the optimized number of TCP connections that should be established for downloading the content. From the test results on real LTE testbed equipped with MEH, we observed up to 34.5% time reduction and in the median case the improvement is 20.5% compared to the plain over-the-top (OTT) HTTP/2.0 protocol.
Multiflash Stereopsis: Depth-Edge-Preserving Stereo with Small Baseline Illumination

Traditional stereo matching algorithms are limited in their ability to produce accurate results near depth discontinuities, due to partial occlusions and violation of smoothness constraints. In this paper, we use small baseline multiflash illumination to produce a rich set of feature maps that enable the acquisition of discontinuity preserving point correspondences. First, from a single multiflash camera, we formulate a qualitative depth map using a gradient domain method that encodes object relative distances. Then, in a multiview setup, we exploit shadows created by light sources to compute an occlusion map. Finally, we demonstrate the usefulness of these feature maps by incorporating them into two different dense stereo correspondence algorithms, the first based on local search and the second based on belief propagation. Experimental results show that our enhanced stereo algorithms are able to extract high-quality discontinuity preserving correspondence maps from scenes that are extremely challenging for conventional stereo methods. We also demonstrate that small baseline illumination can be useful to handle specular reflections in stereo imagery. Different from most existing active illumination techniques, our method is simple, inexpensive, and compact and requires no calibration of light sources.
Recruitment of live donors by candidates for kidney transplantation.

BACKGROUND Little is known about efforts that renal transplant candidates make to recruit live donors. It was hypothesized that preference for live donor kidney transplantation and greater knowledge about live donor transplantation are associated with candidates' initiating conversations about donation with potential donors. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS A cross-sectional study of renal transplant candidates was performed at initial transplant evaluation. Candidates completed a questionnaire that specified whether they had initiated conversations about donation with any potential donors. The questionnaire also measured preference for live donor transplantation, knowledge about transplantation, concern about donor harm, willingness to ask for help in coping with kidney disease, and social support. RESULTS Ninety-six candidates participated. Forty-nine (51%) reported initiating a conversation with at least one potential donor. In multivariable logistic regression, domains associated with initiating a conversation included: preference for live donor transplantation, willingness to ask for help, and female gender. Older age was associated with a lower odds of initiating a conversation. Knowledge, concern about donor harm, social support, and ethnicity were not associated with initiating a conversation with a donor. CONCLUSIONS Attempts at donor recruitment by kidney transplant candidates are common. These findings suggest that interventions that influence preferences about transplantation and willingness to ask others for help are logical targets to enhance access to live donor transplantation.
Optimisation du Primal pour les SVM

L'apprentissage de SVM par optimisation directe du primal est tres etudie depuis quelques temps car il ouvre de nouvelles perspectives notamment pour le traitement de donnees structurees. Nous proposons un nouvel algorithme de ce type qui combine de facon originale un certain nombre de techniques et idees comme la methode du sous-gradient, l'optimisation de fonctions continues non partout differentiables, et une heuristique de shrinking.
Influence of Postactivation Potentiation on Sprinting Performance in Professional Rugby Players

Bevan, HR, Cunningham, DJ, Tooley, EP, Owen, NJ, Cook, CJ, and Kilduff, LP. Influence of postactivation potentiation on sprinting performance in professional rugby players. J Strength Cond Res 24(3): 701-705, 2010-After a bout of high-intensity exercise of short duration (preload stimulus), the muscle is in both a fatigued and potentiated (referred to as postactivation potentiation [PAP]) state. Consequently, subsequent muscle performance depends on the balance of these 2 factors. Although research has shown PAP to be an effective method of increasing power during both the squat jumps, little data exist on its effect on more functional activities such as sprinting. The present study aimed to determine the effect of PAP on sprint performance in professional rugby players. Sixteen professional male rugby players performed 5 10-m sprints (with a 5-m split): baseline, 4, 8, 12, and 16 minutes after the preload stimulus (1 set of 3 repetitions of the back squat at 91% 1 Repetition Maximum [RM]). There was no significant time effect over the duration of the study with regard to 5-m (p = 0.175) and 10-m sprint times (p = 0.401). However, when individual responses to PAP were taken into account, a significant improvement in sprint performance was observed over both 5 (Baseline: 1.09 ± 0.06s vs. Best time: 1.05 ± 0.05s, p = 0.002) and 10 m (Baseline: 1.83 ± 0.08s vs. Best time: 1.79 ± 0.08s, p = 0.003) compared with the baseline sprint. We conclude that sprinting performance is enhanced after a preload stimulus providing adequate and individualized recovery is given between the 2 activities, and this may have important implications for training speed.
A new alcohol dehydrogenase, reactive towards methanol, from Bacillus stearothermophilus.

An NAD+-dependent alcohol dehydrogenase (ADH) was purified to homogeneity from an aerobic strain of Bacillus stearothermophilus, DSM 2334 (ADH 2334), and compared with the ADH from B. stearothermophilus NCA 1503 (ADH 1503). When an antibody raised against ADH 2334 was used, no cross-reactivity with ADH 1503 was observed on Western blots; by means of an enzyme-linked-immunoabsorbent-assay ('e.l.i.s.a.') procedure, it was found that ADH 1503 had less than 6% of the antigenic activity of ADH 2334. Amino acid analyses detected very small differences in composition, equivalent to about 40 sequence changes, between the two enzymes. The new enzyme has the same six-amino-acid N-terminal sequence as ADH 1503. ADH 2334, but not ADH 1503, is reactive towards methanol; both enzymes can oxidize ethanol, propan-1-ol, butan-1-ol and butan-2-ol. The new enzyme has a distinctive pH optimum at pH 5.5-6 and has significantly lower KEthanolm and kEthanolcat. values than those of ADH 1503. From steady-state kinetic parameters of the reaction with ethanol, propan-1-ol and butan-1-ol, it was shown that ADH 2334 has an ordered mechanism in both directions, with NAD+ being the compulsory first substrate in alcohol oxidation and NADH release being the rate-limiting step. ADH 1503 has an ordered addition of NAD+ and alcohol, but NADH release is not rate-limiting.
Regulation of the muscle fiber micro environment by activated satellite cells during hypertrophy

Our aim in the current study was to determine the necessity of satellite cells for long‐term muscle growth and maintenance. We utilized a transgenic Pax7‐DTA mouse model, allowing for the conditional depletion of > 90% of satellite cells with tamoxifen treatment. Synergist ablation surgery, where removal of synergist muscles places functional overload on the plantaris, was used to stimulate robust hypertrophy. Following 8 wk of overload, satellite cell‐depleted muscle demonstrated an accumulation of extracellular matrix (ECM) and fibroblast expansion that resulted in reduced specific force of the plantaris. Although the early growth response was normal, an attenuation of hypertrophy measured by both muscle wet weight and fiber cross‐sectional area occurred in satellite cell‐depleted muscle. Isolated primary myogenic progenitor cells (MPCs) negatively regulated fibroblast ECM mRNA expression in vitro, suggesting a novel role for activated satellite cells/MPCs in muscle adaptation. These results provide evidence that satellite cells regulate the muscle environment during growth. —Fry, C. S. , Lee, J. D. , Jackson, J. R. , Kirby, T. J., Stasko, S. A, Liu, H. , Dupont‐Versteegden, E. E. , McCarthy, J. J., Peterson, C. A. Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophy. FASEB J. 28, 28–1654 (1665). www.fasebj. org
Broad New OS Research: Challenges and Opportunities

Contemporary software systems are beset by problems that create challenges and opportunities for broad new OS research. To illustrate, we describe five areas where broad OS research could significantly improve the current user experience. These areas are dependability, security, system configuration, system extension, and multi-processor programming. In each area we explore how contemporary systems fall short. Where we have thought of possible solutions, we offer directions for future research. To prove our point that opportunities for new OS research exist, we describe Singularity, a research project at Microsoft Research. Singularity is a new operating system designed to explore solutions to four of the challenges we have identified. Singularity incorporates three specific design decisions in order to increase system dependability and improve system security, configuration, and extension. These design decisions include the adoption of an abstract instruction set as part of the system binary interface, a unified extension architecture for both the OS and applications, and a first-class application abstraction.
Interpreting the structural mechanism of action for MT7 and human muscarinic acetylcholine receptor 1 complex by modeling protein–protein interaction

MT7 is a selective human muscarinic acetylcholine receptor 1 (hM1) allosteric binder with subnanomolar affinity. Understanding the binding mode of hM1–MT7 will give insights to discover small molecular ligand for hM1. MT7 is a peptide, and hM1 is a G-protein-coupled membrane receptor. Therefore, we have employed homology modeling, protein–protein docking, explicit membrane molecular dynamics (MD) simulations, and molecular mechanic/Poisson-Boltzmann surface area energy decomposition analysis approaches to reveal the hM1–MT7 binding mode. The binding mode is consistent with the experimental data. We have discovered that the binding mode consists of three interaction regions in five residue interaction clusters. By analyzing the cluster representative structures, the cluster residues form an interaction network, which shows a multiple-point-to-site binding mode. Hydrogen binding statistical analysis reveals that E170 (hM1) and R34 (MT7) are both locked in electrostatic cages with counter charges, respectively. This is confirmed by the dynamic distances calculation between these residues, and biological mutant experiments.
Human Regulatory Factor X 4 (RFX4) Is a Testis-specific Dimeric DNA-binding Protein That Cooperates with Other Human RFX Members*

Regulatory factor X (RFX) members are evolutionarily conserved transcription factors that share a highly conserved winged helix DNA-binding domain. Human RFX4 has been isolated from breast cancer as a partial cDNA encoding a short RFX-type DNA-binding domain fused to the estrogen receptor, but the entire structure of RFX4 has been unknown. Here, we report the molecular cloning and characterization of human RFX4. RFX4 contains evolutionarily conserved regions, including a RFX-type DNA-binding domain, a dimerization domain, and other conserved regions, and is closely related to RFX1, RFX2, and RFX3 in structure. The expression of RFX4 is restricted to testis. In vitro synthesized RFX4 protein bound to typical RFX binding sites in a sequence-dependent manner. Immunoprecipitation analyses showed that RFX4 interacts physically with RFX2, RFX3, and RFX4 itself but not with RFX1. In contrast to other mammalian RFX members that form dimers, RFX4 is revealed to have no distinct transcriptional activation domains. By using a chimeric protein of RFX1 and RFX4, the C-terminal domain of RFX4 was shown to be a possible transcriptional repression domain. Taken together, these results indicate that RFX4 is the first mammalian member of RFX family without transcriptional activation capacity and might function through selective interactions with other RFX members in transcriptional regulation.
Bullwhip Effect and the Value of Information Sharing in Supply Chain -- Illustrated by a Shipbuilding Supply Chain

The bullwhip effect in a supply chain seriously decreases the operation efficiency of the supply chain. Information sharing has been used as an important tool to resolve the challenges of supply chain management faced. Firstly, this paper analyzes the causes of bullwhip effect systemically, and then this paper analyzes the value of the information sharing in the a-supplier-multiretailers model. We find some useful conclusions between exist of information and absence of information. At last we use the shipbuilding supply chain to illustrate plenitudinous information sharing will decrease the bullwhip effect.
Evaluación preliminar de un programa para parejas no casadas que han presentado malos tratos

El objetivo de esta investigacion fue efectuar una evaluacion preliminar de un programa de tratamiento dirigido a parejas jovenes no casadas que han presentado malos tratos en su relacion, el cual contemplaba el mejoramiento de las habilidades de comunicacion, empatia y manejo de la ira, entre otros componentes implementados desde el enfoque de terapia y modificacion del comportamiento. Se utilizo un diseno pretest-postest de un solo grupo, con la participacion de cuatro parejas heterosexuales entre 17 y 22 anos de edad (X = 20 anos; DX = 1,89 anos). Los efectos se evaluaron a traves del staxi ii, el aspa (Cuestionario de Asercion en la Pareja), una escala de actitudes hacia la violencia intima, un cuestionario de satisfaccion con el programa y una lista de chequeo de experiencias de maltrato en la pareja. Los resultados evidenciaron decrementos postratamiento significativos en la frecuencia de malos tratos, en la ira como estado y en las actitudes hacia la violencia, asi como una buena satisfaccion con el programa. Se proponen ajustes en los contenidos del mismo, de cara a la realizacion de un ensayo clinico controlado.
Comportamento de risco para transtorno alimentar em universitárias brasileiras

CONTEXTO: Comportamentos de risco para transtornos alimentares envolvem atitudes e praticas inadequadas para com o alimento e o peso e podem ser avaliados com base em instrumentos validados. OBJETIVOS: Avaliar comportamento de risco para transtornos alimentares em universitarias brasileiras das cinco regioes do pais. METODOS: 2.483 universitarias responderam ao Teste de Atitudes Alimentares (EAT-26) nas cinco regioes. A pontuacao no teste foi comparada entre as regioes por meio do teste qui-quadrado. Possiveis associacoes ou correlacoes com curso de graduacao, idade, estado nutricional, renda individual e escolaridade do chefe da familia foram avaliadas pelos coeficientes de Pearson e Spearman. Uma analise de covariância comparou o escore do EAT entre as regioes. RESULTADOS: A frequencia de comportamento de risco para transtornos alimentares variou de 23,7% a 30,1% nas cinco regioes e nao houve diferenca na pontuacao media do EAT e na proporcao de escores positivos para comportamento de risco entre as regioes. Nao houve forte correlacao do escore do EAT com nenhuma das variaveis. CONCLUSAO: Universitarias brasileiras apresentam alta frequencia de comportamentos de risco para TA em todas as regioes do pais. Medidas de prevencao devem ser planejadas para a populacao jovem feminina do Brasil.
Current and future molecular diagnostics in non-small-cell lung cancer

The molecular investigation of lung cancer has opened up an advanced area for the diagnosis and therapeutic management of lung cancer patients. Gene alterations in cancer initiation and progression provide not only information on molecular changes in lung cancer but also opportunities in advanced therapeutic regime by personalized targeted therapy. EGFR mutations and ALK rearrangement are important predictive biomarkers for the efficiency of tyrosine kinase inhibitor treatment in lung cancer patients. Moreover, epigenetic aberration and microRNA dysregulation are recent advances in the early detection and monitoring of lung cancer. Although a wide range of molecular tests are available, standardization and validation of assay protocols are essential for the quality of the test outcome. In this review, current and new advancements of molecular biomarkers for non-small-cell lung cancer will be discussed. Recommendations on future development of molecular diagnostic services will also be explored.
Scheduling rigid demands on continuous-time linear shift-invariant systems

We consider load scheduling on constrained continuous-time linear dynamical systems, such as automated irrigation and other distribution networks. The requested loads are rigid, i.e., the shapes cannot be changed. Hence, it is only possible to shift the order back-and-forth in time to arrive at a feasible schedule. We present a numerical algorithm based on using log-barrier functions to include the state constraints in the social cost function (i.e., an appropriate function of the scheduling delays). This algorithm requires a feasible initialization. Further, in another algorithm, we treat the state constraints as soft constraints and heavily penalize the constraint violations. This algorithm can even be initialized at an infeasible point. The applicability of both these numerical algorithms is demonstrated on an automated irrigation network with two pools and six farms.