Miracle-dz/UniFAR-FTUs huggingface dataset:
A review of the marriage analogy in relationship marketing

This paper offers a review of the marriage analogy in relationship marketing as used by many marketing authors. Accepting a Christian view of marriage as adopted in Levitt's seminal paper, marriage is seen as a successful, public, contractual, and monogamous relationship, freely entered into by two consenting adults of different genders, which is intended to endure a lifetime. However, while parallels do exist in relationship development, the metaphor fails to deliver on issues concerning the number of parties involved in the relationship, on the attendant costs and benefits, on the willingness of the parties involved and on the “ideal” timescale of the relationship. Parallels from the full range of relationships between the sexes, both functional and dysfunctional, suggest polygamy, prostitution, stalking, rape, and seduction may be more apposite.
Transcriptional and translational control of the genes for the mating pair formation apparatus of promiscuous IncP plasmids

The trb operon of broad-host-range plasmid RK2 encodes most of the genes required for formation of mating-pair apparatus and is thus essential for the promiscuous spread of this plasmid. Only two promoters, lying upstream of trbA and trbB, have been identified for this operon. trbB encodes a protein belonging to a large family of proteins which function in the assembly of apparatuses associated with the cell surface. trbA encodes a repressor protein, one of whose targets is the trbB promoter. trbAp is arranged as a face-to-face divergent promoter with trfAp, the strongest of the three promoters in this region. trfAp completely inhibits trbAp unless it is repressed by the KorA protein, a key regulator encoded in the plasmid's central control operon. We show that when trfAp is firing constitutively, it also appears to interfere with trbBp, but that trbBp activity increases when trfAp activity is decreased by repression or mutation. A second global regulator encoded in the central control operon, KorB, represses trbBp, trfAp, and trbAp. The results presented here show that both KorB and TrbA are necessary for full repression of trbBp. The region between trbA and trbB encodes a large inverted repeat which has been proposed to modulate translation of trbB on transcripts which are initiated at trbAp but not trbBp. Using translational fusions to lacZ, we show that translation of trbB is completely blocked when transcripts incorporate the inverted repeat upstream of trbB but proceeds with reasonable efficiency when deletions remove the sequences predicted to sequester the ribosome binding site. Results from both transcriptional fusion and direct measurement of transcript size and intensity by Northern blot analysis show that most trbA transcripts are monocistronic and serve to express only trbA, although some transcription continues into trbB. The monocistronic trbA transcript appears to be the result of transcription termination downstream of trbA. Thus, trbAp and trbA appear to form an operon distinct from the trbB-trbP operon. Consequently, trbA and the switch that controls its expression help to provide the sequential steps which allow efficient expression of transfer genes during plasmid establishment but tight repression once the plasmid is established.
A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells

Recent advances in fluorescent ligand technology have enabled the study of G protein-coupled receptors in their native environment without the need for genetic modification such as addition of N-terminal fluorescent or bioluminescent tags. Here, we have used a non-imaging plate reader (PHERAstar FS) to monitor the binding of fluorescent ligands to the human adenosine-A3 receptor (A3AR; CA200645 and AV039), stably expressed in CHO-K1 cells. To verify that this method was suitable for the study of other GPCRs, assays at the human adenosine-A1 receptor, and β1 and β2 adrenoceptors (β1AR and β2AR; BODIPY-TMR-CGP-12177) were also carried out. Affinity values determined for the binding of the fluorescent ligands CA200645 and AV039 to A3AR for a range of classical adenosine receptor antagonists were consistent with A3AR pharmacology and correlated well (R2 = 0.94) with equivalent data obtained using a confocal imaging plate reader (ImageXpress Ultra). The binding of BODIPY-TMR-CGP-12177 to the β1AR was potently inhibited by low concentrations of the β1-selective antagonist CGP 20712A (pKi 9.68) but not by the β2-selective antagonist ICI 118551(pKi 7.40). Furthermore, in experiments conducted in CHO K1 cells expressing the β2AR this affinity order was reversed with ICI 118551 showing the highest affinity (pKi 8.73) and CGP20712A (pKi 5.68) the lowest affinity. To determine whether the faster data acquisition of the non-imaging plate reader (~3 min per 96-well plate) was suitable for high throughput screening (HTS), we screened the LOPAC library for inhibitors of the binding of CA200645 to the A3AR. From the initial 1,263 compounds evaluated, 67 hits (defined as those that inhibited the total binding of 25 nM CA200645 by ≥40%) were identified. All compounds within the library that had medium to high affinity for the A3AR (pKi ≥6) were successfully identified. We found three novel compounds in the library that displayed unexpected sub-micromolar affinity for the A3AR. These were K114 (pKi 6.43), retinoic acid p-hydroxyanilide (pKi 6.13) and SU 6556 (pKi 6.17). Molecular docking of these latter three LOPAC library members provided a plausible set of binding poses within the vicinity of the established orthosteric A3AR binding pocket. A plate reader based library screening using an untagged receptor is therefore possible using fluorescent ligand opening the possibility of its use in compound screening at natively expressed receptors.
Dynamic Spectrum Management: Complexity and Duality

Consider a communication system whereby multiple users share a common frequency band and must choose their transmit power spectral densities dynamically in response to physical channel conditions. Due to co-channel interference, the achievable data rate of each user depends on not only the power spectral density of its own, but also those of others in the system. Given any channel condition and assuming Gaussian signaling, we consider the problem to jointly determine all users' power spectral densities so as to maximize a system-wide utility function (e.g., weighted sum-rate of all users), subject to individual power constraints. For the discretized version of this nonconvex problem, we characterize its computational complexity by establishing the NP-hardness under various practical settings, and identify subclasses of the problem that are solvable in polynomial time. Moreover, we consider the Lagrangian dual relaxation of this nonconvex problem. Using the Lyapunov theorem in functional analysis, we rigorously prove a result first discovered by Yu and Lui (2006) that there is a zero duality gap for the continuous (Lebesgue integral) formulation. Moreover, we show that the duality gap for the discrete formulation vanishes asymptotically as the size of discretization decreases to zero.
Age associated axonal features in HNPP with 17p11.2 deletion in Japan

Objective: To clarify age related changes in the clinicopathological features of hereditary neuropathy with liability to pressure palsy (HNPP) in Japanese patients with deletion of 17p11.2, particularly concerning axonal abnormalities. Methods: Forty eight proband patients from 48 HNPP families were assessed as to clinical, electrophysiological, and histopathological features, including age associated changes beyond those in controls. Results: Motor conduction studies showed age associated deterioration of compound muscle action potentials in nerves vulnerable to repetitive compression (median, ulnar, and peroneal nerves), but not in others such as the tibial nerve. Sensory conduction studies revealed more profound reduction of action potentials than motor studies with little age related change. Large myelinated fibre loss was seen in the sural nerve irrespective of age at examination. Conclusions: Irreversible axonal damage may occur at entrapment sites in motor nerves in HNPP patients, progressing with aging. Sensory nerves may show more profound axonal abnormality, but without age association. The electrophysiological features of HNPP are presumed to be a mixture of abnormalities occurring from early in life and acquired features caused by repetitive insults at entrapment sites. Unlike Charcot-Marie-Tooth disease type 1A, age associated axonal damage may not occur unless the nerves are subjected to compression.
Heavenly Talk: Discourse, Artifacts, and Children’s Understanding of Elementary Astronomy

In the literature on children’s understanding of astronomical concepts, such as the shape of the earth and gravitation, the difficulties that children have in conceptualizing these phenomena have been documented in many studies. The purpose of this research is to critically scrutinize these findings by taking a situated and discursive perspective on reasoning (and cognitive development). Instead of viewing understanding as the overt expression of underlying mental models, children’s responses in interview studies should be regarded as situated and as dependent on the tools available as resources for reasoning. By modifying the interview situation through the introduction of a globe as a tool for thinking, the outcomes are radically different from those reported earlier. None of the problems that have been reported, where children, for instance, claim that people can fall off the earth, can be detected. Even among the youngest participants gravitation is often invoked as an explanatory concept. It is argued that the globe in this case serves as an efficient prosthetic device for thinking, and this illustrates the tool-dependent nature of human reasoning.
How do I use my living and lived experience to influence creative economic independence in others?

Due to the high levels of unemployment in Durban South Africa, the New Venture Creation (NVC) groups I coached/mentored were seeking to become self-employed, to find social and economic independence. I have observed that many of the people in my NVC groups seemed to lack, self-confidence and self-esteem in the start-up process of their business. These lacunae pose a problem, as they are all necessary if one wants to create a viable, sustainable and profitable business. The reason that I coach these emerging entrepreneurs is to assist in building their self-confidence and self-esteem so that they have the courage to “go for it”. The problem I have sought to address in this research is: How do I influence emerging entrepreneurs to become sufficiently self-confident to be able to design, establish and sustain their own employment and employment for others? I work on the assumption that most people have the capacity to be self-employed. I have used autoethnography with action research to describe the interventions that I initiated, report on their implementation, as well as the evolution of new perceptions and understandings that developed as a result. By using my own and the participants visual data with still images and video with visual narrative I demonstrate the evidence of my living theory and self-study to influence creative economic independence in others and reflect critically on what has been done and achieved, and critically assess the way forward. I verbally explained the ethical issue of obtaining consent to use names and photographs in my study to the participants. My explanation was followed by obtaining written consent from the five key participants and others in the pictorial data.
A categorical approach to affective gesture recognition

Studies on emotion are currently receiving a lot of attention. The importance of emotion in the development and support of intelligent and social behaviour has been highlighted by studies in psychology and neurology. Hence, the recognition of affective states has also become a critical feature in robot social development, with robots assumed to take on a role as social companion. In this paper, we address the issue of endowing robots with the ability to learn incrementally to recognize the affective state of their human partner by interpreting their gestural cues. We propose a model that can self-organize postural features into affective categories, and use contextual feedback from the partner to drive the learning process.
Heart rate reactivity and variability as psychophysiological links between stress, anxiety, depression, and cardiovascular disease: Implications for health psychology interventions

While there are some data indicating that health psychologists can assist with the rehabilitation and prevention of coronary heart disease (CHD), most “psychological” interventions are aimed at variables that aresome causal distance from the actual end-organ itself (i.e., the heart). However, medical focus is often towards physiological indices such as heart rate reactivity (HRR) and heart rate variability (HRV) while under stress, because these have been shown to predict both gradual arterial deterioration and sudden death. These cardiovascular indices of coronary health may also be used as treatment variables within psychological interventions for stress, anxiety, and depression. This paper describes the links that HRR and HRV make between common “psychological” presenting problems of stress, anxiety, and depression, and the more life-threatening CHD. In addition, some suggestions for potential health psychological interventions in everyday practice are made, based on the wider literature on stress, anx.
The dynamics of individual male earnings in Great Britain: 1991-1999

In this paper I analyse the dynamic structure of earnings in Great Britain for the period 1991-1999 by decomposing the earnings covariance structure into its permanent and transitory components. Using information on monthly earnings of male full-time employees from the first nine waves of the British Household Panel Study I find that earnings inequality increases over the Nineties. However, earnings mobility may have also increased. That is, for this period earnings persistence falls. Surprisingly, I also find that relative earnings persistence declines over the life cycle, which implies lower mobility for younger cohorts. This evidence is at odds with previous literature on earnings dynamics both for Britain and other OECD countries. Unlike recent studies, I also consider the effects of observed characteristics on the covariance structure of log earnings and find that human capital and job related characteristics account for nearly all persistent earnings differences and that the transitory component is highly persistent.
ANALISIS PENGARUH TINGKAT KANTUK TERHADAP KECEPATAN REAKSI MASINIS DAERAH OPERASI II BANDUNG

Direktorat Keselamatan Perkeretaapian mencatat pada tahun 2009 hingga tahun 2013 diperoleh 24.73% kecelakaan kereta disebabkan oleh human error. Salah satu bentuk human error yaitu keterlambatan merespon sinyal yang diakibatkan oleh kelelahan seperti perubahan pola tidur, shift kerja, dan kuantitas istirahat. Pada penelitian ini akan dibahas mengenai pengaruh tingkat kantuk terhadap kecepatan reaksi masinis. Tingkat kantuk dilihat secara objektif dari kecepatan reaksi dan secara subjektif dari Karolinska Sleepiness Scale dan Epworth Sleepiness Scale. Berdasarkan hasil pengolahan data didapatkan tingkat kantuk masinis meningkat saat sesudah dinasan dan kecepatan reaksi semakin lambat. Kata Kunci: kecelakaan kereta, kecepatan reaksi, tingkat kantuk ABSTRACT Directorate of Railway Safety based in 2009 to 2013 gained 24.73% train crash was caused by human error. One form of human error that the delay in responding to the signals caused by fatique induced changes in sleep patterns, shift work, and quantity rest . This will be discussed on the research about the influence of the reaction time against sleepiness level machinist. Levels of sleepiness were seen objectively from the reaction time and subjectively from the Karolinska Sleepiness Scale and Epworth Sleepiness Scale . Based on the results obtained by the data processing level increased when sleepiness level machinist after duties and reaction time is getting slower. Keywords: train accident, reaction time, sleepiness level
Des crises commerciales et de leur retour périodique

Au milieu des annees 1850, l’economiste francais Clement Juglar presenta l’une des premieres expressions de l’idee de cycle economique. Il publia en 1862, Des crises et de leur retour periodique en France, en Angleterre et aux Etats-Unis. Il travailla le reste de sa vie a mieux fonder theoriquement et empiriquement ses premieres intuitions sur le cycle d’une dizaine d’annees (prosperite-crise-depression) qui lui paraissait rythmer l’evolution economique moderne. En 1889 il publiait la deuxieme edition, largement augmentee et remaniee, de son grand ouvrage sur les crises. C’est l’edition de 1889 qui est proposee dans ce volume. L’ouvrage est accompagne de deux textes courts, syntheses des analyses que presenta Juglar d’abord au tournant 1860, puis une trentaine d’annees plus tard : Les articles « crises commerciales » qu’il publia en 1863 dans le Dictionnaire general de la politique de M. Block (1863) et en 1891 dans le Nouveau dictionnaire de l’economie politique (L. Say et J. Chailley).
Plugging in and into Code Bubbles

Code Bubbles is an attempt to redefine the user interface for an integrated programming environment. As it represents a whole new user interface, implementing it as a plug-in is inherently difficult. We get around this difficulty by combining two different plug-in architectures, a standard one based on registrations and callbacks, and a message-based one that puts the plug-in at arms length and defines a narrower two-way interface. This paper describes both how we have implemented Code Bubbles as a plug-in to Eclipse and how Code Bubbles itself is implemented as a set of plug-ins representing the different aspects of the environment, using both traditional and message-based plug-in architectures as appropriate.
Differences In Dominant And Non-Dominant Handgrip Strength Of Male Golf Professionals Measured Using The Jamar Dynamometer

Grip strength is often used clinically as an indicator of hand function and as a quick and effective outcome measure for rehabilitation. There is little published data for normative handgrip strength for specific populations. Published bilateral grip strength values provide no insight into expected ranges or relationships for professional sportsmen and women. This study explored the range and relationship of dominant and non-dominant handgrip strength in professional golfers. A small, cross sectional study recruiting 36 professional golfers was carried out. Bilateral grip strength was measured using a JAMAR ® dynamometer and standardised measurement protocols. Results indicated that in professional golfers, non-dominant hands were significantly stronger (p=0.009, 95%CI 3.95 to 0.61) than the dominant hand by a mean of 2.28kg. Clinicians need to consider that, for this potential patient group, optimum hand rehabilitation may need to aim for the non-dominant hand to regain a stronger grip force than the dominant hand.
On Equivalence of Martingale Tail Bounds and Deterministic Regret Inequalities

We study an equivalence of (i) deterministic pathwise statements appearing in the online learning literature (termed \emph{regret bounds}), (ii) high-probability tail bounds for the supremum of a collection of martingales (of a specific form arising from uniform laws of large numbers for martingales), and (iii) in-expectation bounds for the supremum. By virtue of the equivalence, we prove exponential tail bounds for norms of Banach space valued martingales via deterministic regret bounds for the online mirror descent algorithm with an adaptive step size. We extend these results beyond the linear structure of the Banach space: we define a notion of \emph{martingale type} for general classes of real-valued functions and show its equivalence (up to a logarithmic factor) to various sequential complexities of the class (in particular, the sequential Rademacher complexity and its offset version). For classes with the general martingale type 2, we exhibit a finer notion of variation that allows partial adaptation to the function indexing the martingale. Our proof technique rests on sequential symmetrization and on certifying the \emph{existence} of regret minimization strategies for certain online prediction problems.
Preclinical Development Dual-Fluorescence Isogenic High-Content Screening for MUC 16 / CA 125 Selective Agents

Most of the currently used cancer chemotherapies are based on compounds that inhibit general cellular mechanisms, such as DNA replication or tubulin function, and lack specificity in relation to features of the cancer cell. Recent advances in genomic studies have increased our knowledge of tumor cell biology, and a panoply of new targets have been postulated. This has provided an opportunity to develop and validate drugs that specifically target cancer cells through their unique genetic characteristics. Identification of MUC16/CA125 both as a marker and a driver of transformation led us to design a target-based high-content screen to identify and classify compounds that exhibit differential effect on MUC16-expressing cells. We developed a coculture assay in 384-well plate containing isogenic ovarian cancer cells that are positive or negative for the MUC16 protein. High-throughput screening of our small molecule pilot library led to the identification of compounds preferentially cytotoxic to MUC16þ or MUC16 cells, using a Preferential Score analysis. We compared screening results in both A2780 and SK-OV-3 ovarian cancer cells in single and coculture settings. We also identified compounds that were cytotoxic for both types of ovarian cancer cells regardless of the MUC16 status. Compounds that were preferentially targeting MUC16 cells were subsequently confirmed by caspase-induction assays. The isogenic, dual-color fluorescence strategy is an innovative approach that can effectively identify novel drug candidates, selectively targeting cancer cells that have unique molecular properties. Mol Cancer Ther; 10(10); 1939–48. 2011 AACR.
Clarifying Differences Between Reading Skills and Reading Strategies

The terms reading skill and reading strategy are central to how we conceptualize and teach reading. Despite their importance and widespread use, the terms are not consistently used or understood. This article examines the current and historical uses of the terms, defines them, and describes their differences, similarities, and relationships. Implications for teaching reading skills and strategies are discussed.
An improved Hadamard measurement matrix based on Walsh code for compressive sensing

Measurement matrix design is a very significant part in the whole process of compressive sensing, the ratio of the signal compression and the receiver reconstruction accuracy of the original signal are all determined by it. An improved Hadamard measurement matrix based on Walsh code for compressive sensing is proposed in this paper. Simulation results demonstrate that the measure performance of the proposed measurement matrix is better than original Hadamard measurement matrix.