Miracle-dz/UniFAR-FTUs huggingface dataset:
Identifying top football players and springboard clubs from a football player collaboration and club transfer networks

We consider all players and clubs in top twenty world football leagues in the last fifteen seasons. The purpose of this paper is to reveal top football players and identify springboard clubs. To do that, we construct two separate weighted networks. Player collaboration network consists of players, that are connected to each other if they ever played together at the same club. In directed club transfer network, clubs are connected if players were ever transferred from one club to another. To get meaningful results, we perform different network analysis methods on our networks. Our approach based on PageRank reveals Christiano Ronaldo as the top player. Using a variation of betweenness centrality, we identify Standard Liege as the best springboard club.
Requirement for Donor and Recipient CD40 Expression in Cardiac Allograft Rejection: Induction of Th1 Responses and Influence of Donor-Derived Dendritic Cells1

Costimulation through the CD40-CD40 ligand (CD40L) pathway is critical to allograft rejection, in that anti-CD40L mAb therapy prolongs allograft survival. However, the majority of studies exploring CD40-CD40L interactions have targeted CD40L. Less is known about the requirement for donor- and/or host-derived CD40 during rejection. This study assessed the relative contributions of donor and recipient CD40 expression to the rejection process. As the effectiveness of costimulatory blockade may be mouse strain dependent, this study explored the requirement for donor and recipient CD40 expression in BALB/c and C57BL/6 mice. Wild-type (WT) and CD40−/− BALB/c recipients readily rejected WT and CD40−/− C57BL/6 allografts, and rejection was associated with a prominent Th1 response. In contrast, CD40−/− C57BL/6 recipients failed to reject WT or CD40−/− BALB/c allografts and did not mount Th1 or Th2 responses. However, injection of donor CD40−/− dendritic cells induced both Th1 and Th2 responses and allograft rejection in CD40−/− C57BL/6 recipients. Finally, WT C57BL/6 mice rejected CD40−/− allografts, but this rejection response was associated with muted Th1 responses. These findings demonstrate that 1) CD40 expression by the recipient or the graft may impact on the immune response following transplantation; 2) the requirement for CD40 is influenced by the mouse strain; and 3) the requirement for CD40 in rejection may be bypassed by donor DC. Further, as CD40 is not required for rejection in BALB/c recipients, but anti-CD40L mAb prolongs graft survival in these mice, these results suggest that anti-CD40L therapy functions at a level beyond disruption of CD40-CD40L interactions.
Safe Online Learning Using Barrier Functions

—We present a method for guaranteeing the safety of online learning schemes. The method uses barrier certiﬁcates and Sums-of-Squares programming to ﬁnd a safe region of state space and a controller which renders that space positively invariant. This safe set and controller are then used to create “training wheels”, which can transform unsafe controllers into safe ones. These training wheels alter the given controller only when the state nears the edge of the safe region. Thus, except for where it would otherwise lead to falling, the original controller remains unchanged. For a given learning scheme, this projection is performed for each controller rollout to generate a safety guarantee for the scheme with minimal interference. We have simulation results for a simple car model and a simple hopping model, and plan to demonstrate safe learning of a hopping controller on the robot RAM one .
Osmolarity and growth phase overlap in regulation of Salmonella typhi adherence to and invasion of human intestinal cells

The study of the effects of osmolarity and growth phase on Salmonella typhi adherence to and invasion of Henle 407 epithelial cells provides the first evidence of a clear overlap between these two environmental stimuli. High-osmolarity conditions are required in the late-log phase for optimum induction of the adherent and invasive phenotypes.
Advances in Brief PRL-3 and PRL-1 Promote Cell Migration , Invasion , and Metastasis 1 , 2

We demonstrate here that Chinese hamster ovary cells stably expressing PRL-3, a Mr 20,000 prenylated protein tyrosine phosphatase, or its relative, PRL-1, exhibit enhanced motility and invasive activity. A catalytically inactive PRL-3 mutant has significantly reduced migrationpromoting activity. We observe that PRL-3 is associated with diverse membrane structures involved in cell movement. Furthermore, we show that PRL-3and -1-expressing cells, but not control cells, induce metastatic tumor formation in mice. Thus, our results deliver the first evidence for a causative role of PRL-3 and -1 in promoting cell motility, invasion activity, and metastasis.
Successful transseptal puncture for radiofrequency ablation of left atrial tachycardia after closure of secundum atrial septal defect with Amplatzer septal occluder

Abstract We report on a 37-year-old woman presenting with atrial arrhythmias after catheter closure of a secundum atrial septal defect with an Amplatzer septal occluder device. Eletrophysiological studies suggested that the arrhythmia originated from the left atrium, from an area near the device. Transseptal puncture was successfully performed under transoesophageal guidance and the arrhythmia was successfully ablated. This case showed that transseptal puncture can be safely performed in the presence of an Amplatzer septal occluder device under transoesophageal echocardiography guidance and we speculate that the device may have created the substrate for the arrhythmia.
Finite-state canonicalization techniques for historical German

Icherklarehiermit,dassichankeineranderenHochschuleeinPromotionsver-fahreneroﬀnethabe. Zudemerklareichhiermit,dassdieDissertationselb-standigundohneunzulassigeHilfeDritterverfasstwurdeundbeiderAb-fassungnurdieinderDissertationangegebenenHilfsmittelbenutztsowieallewortlichoderinhaltlichubernommenenStellenalssolchegekennzeichnetwurden.Des Weiteren erklare ich, dass die Dissertation in der gegenwartigen odereineranderenFassungbeikeineranderenFakultateinerwissenschaftlichenHochschulezurBegutachtungimRahmeneinesPromotionsverfahrensvorgele-genhat.BryanJurishBerlin,Januar2011
Fenoldopam reduces the need for renal replacement therapy and in-hospital death in cardiovascular surgery: a meta-analysis.

OBJECTIVE Acute renal failure is a common and threatening complication in patients undergoing cardiovascular surgery. To determine the efficacy of fenoldopam in the prevention of acute renal failure, the authors performed a systematic review of randomized, controlled trials and propensity-matched studies in patients undergoing cardiovascular surgery. DESIGN Meta-analysis. SETTING Hospitals. PARTICIPANTS A total of 1,059 patients from 13 randomized and case-matched studies were included in the analysis. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Google Scholar, PubMed, and scientific sessions were searched (updated November 2006). Authors and external experts were contacted. Four unblinded reviewers selected controlled trials that used fenoldopam in the prevention or treatment of acute renal failure in cardiovascular surgery. Four reviewers independently abstracted patient data, treatment characteristics, and outcomes. Pooled estimates showed that fenoldopam consistently and significantly reduced the need for renal replacement therapy (odds ratio = 0.37 [0.23-0.59], p < 0.001) and in-hospital death (odds ratio = 0.46 [0.29-0.75], p = 0.01). These benefits were associated with shorter intensive care unit stay (weighted mean difference [WMD] = -0.93 days [-1.27; -0.58], p = 0.002). Sensitivity analyses, tests for small study bias, and heterogeneity assessment further confirmed the main analysis. CONCLUSIONS This meta-analysis provides evidence that fenoldopam may confer significant benefits in preventing renal replacement therapy and reducing mortality in patients undergoing cardiovascular surgery.
Achieving Cloud Scalability with Microservices and DevOps in the Connected Car Domain

The connected car business has high demands on the exchange of data and files between the connected car on the road, and a variety of services in the backend. To solve current and upcoming challenges in the best way, a scalable and flexible architecture and team setup is needed. The paper has its background in the automotive IT industry at Elektrobit (EB) and describes our starting point, challenges and practical experiences. We have chosen microservices as an architectural paradigm in order to be able to replicate granular services for scalability, and to easily replace a deprecated service. For the development and operations of the services, we decided to have one team which is responsible for the backend infrastructure in the cloud. Also a DevOps culture was established. This allows us to deploy quickly services with increased operational efficiency and code quality.
Passification-based robust flight control system design

Abstract A robust autopilot for attitude control of the flexible aircraft under parametric uncertainty is designed. The high gain controller with forced sliding motions is used to secure adaptability in the wide region of the aircraft model parameters. The shunting method is applied to ensure the closed-loop system stability in the face of the lack of the aircraft state information. The sequential reference model is used to assign the desired closed-loop system performance. An example illustrating a typical design procedure for aircraft attitude control in the horizontal plane for different flight conditions is given. The system robustness with respect to uncertain plant parameters is studied. The simulation results demonstrate efficiency and high robustness of the suggested control method.
PI-FLAME: A parallel immune system simulator using the FLAME graphic processing unit environment

Agent-based models (ABMs) are increasingly being used to study population dynamics in complex systems, such as the human immune system. Previously, Folcik et al. (The basic immune simulator: an agent-based model to study the interactions between innate and adaptive immunity. Theor Biol Med Model 2007; 4: 39) developed a Basic Immune Simulator (BIS) and implemented it using the Recursive Porous Agent Simulation Toolkit (RePast) ABM simulation framework. However, frameworks such as RePast are designed to execute serially on central processing units and therefore cannot efficiently handle large model sizes. In this paper, we report on our implementation of the BIS using FLAME GPU, a parallel computing ABM simulator designed to execute on graphics processing units. To benchmark our implementation, we simulate the response of the immune system to a viral infection of generic tissue cells. We compared our results with those obtained from the original RePast implementation for statistical accuracy. We observe that our implementation has a 13× performance advantage over the original RePast implementation.
Molecular identification of some Haemaphysalis species (Acari: Ixodidae) using mitochondrial and nuclear evidences in parts of Iran

Abstract Haemaphysalis is the second largest ixodid tick genus. We decided to identify the Iranian Haemaphysalis species with the analysis of mitochondrial (COI & 16S rRNA) and nuclear (ITS2) gene sequences. Finally, 21 PCR products were sequenced, successfully. Phylogenetic trees were analyzed using BEAST software and Bayesian Inference method. Ha. sulcata and Ha. punctata were well differentiated using the 16S rRNA, COI and ITS2 genes. According to 16S rRNA and COI phylogenetic trees Ha. inermis is situated as an ancestral clade.
Phase 1 dose‐escalation trial evaluating the combination of the selective MET (mesenchymal‐epithelial transition factor) inhibitor tivantinib (ARQ 197) plus erlotinib

Amplification of the mesenchymal‐epithelial transition factor (MET) gene can promote tumor resistance to epidermal growth factor receptor (EGFR) inhibition. Dual EGFR‐MET inhibition may overcome this resistance. Tivantinib (ARQ 197) is a selective, oral, non–ATP‐competitive, small‐molecule inhibitor of the MET receptor tyrosine kinase. This phase 1 trial assessed the safety, pharmacokinetics, and preliminary antitumor activity of tivantinib combined with the EGFR inhibitor erlotinib.
Molecular cloning and expression analysis of MAT 1 gene in black tiger shrimp ( Penaeus monodon )

MAT1 (ménage à trois 1), an assembly factor and targeting subunit of the CDK-dependent kinase (CAK), can regulate the cell cycle, transcription, and DNA repair. This study was intended to investigate the role of MAT1 in the reproductive maturation of black tiger shrimp (Penaeus monodon). In this study, the P. monodon MAT1 (PmMAT1) gene was identified and characterized. The full-length cDNA of PmMAT1 was 1490 bp in length with an open-reading frame of 993 bp corresponding to 330 amino acids. The temporal expression of PmMAT1 in various tissues was measured by quantitative real-time PCR with the highest expression
Phosphorylation of retinoblastoma protein in rat brain after transient middle cerebral artery occlusion

Although mature neurones do not replicate genomic DNA, some cell cycle‐related kinases are aberrantly activated in neurones after ischaemia. As hyper‐phosphorylation of retinoblastoma (Rb) protein is the common pathway in mitotic signal cascade, this study investigated the phosphorylation state of the Rb protein as well as its mRNA level in rat brain after transient middle cerebral artery (MCA) occlusion. Immunohisto‐chemical analysis revealed that neurones in the sham‐operated brain expressed Rb protein without the hyperphosphorylated form. Immunoreactivity for the hyperphosphorylated form of Rb protein progressively increased from 1 h to 3 days after ischaemia in neurones in the MCA territory. Western blot analysis demonstrated a similar change. However, reverse transcription‐polymerase chain reaction study revealed that Rb showed no definite change at the mRNA level. These results suggest that Rb protein is progressively hyper‐phosphorylated in the brain after ischaemia, which may activate apoptotic mechanisms in neuronal cells of the brain after ischaemia.
Involvement of the Wnt signaling pathway and cell apoptosis in the rat hippocampus following cerebral ischemia/reperfusion injury

We investigated the role of the Wnt signaling pathway in cerebral ischemia/reperfusion injury by examining β-catenin and glycogen synthase kinase-3β protein expression in the rat hippocampal CA1 region following acute cerebral ischemia/reperfusion. Our results demonstrate that cell apoptosis increases in the CA1 region following ischemia/reperfusion. In addition, β-catenin and glycogen synthase kinase-3β protein expression gradually increases, peaking at 48 hours following reperfusion. Dickkopf-1 administration, after cerebral ischemia/reperfusion injury, results in decreased cell apoptosis, and β-catenin and glycogen synthase kinase-3β expression, in the CA1 region. This suggests that β-catenin and glycogen synthase kinase-3β, both components of the Wnt signaling pathway, participate in cell apoptosis following cerebral ischemia/reperfusion injury.
Frequency resource allocation strategy with QoS support in hybrid cellular and Device‐to‐Device networks

Hybrid networks, comprising a conventional cellular network overlaid with Device‐to‐Device (D2D), offer efficient way to improve system throughput. In this paper, a novel orthogonal frequency‐division multiple access channel‐assignment method is proposed for hybrid network. The proposed approach is optimal in terms of throughput and is subjected to a sensible QoS requirement, which guarantees that macrocell and D2D achieve a prescribed data rate and outage probability, respectively. Our solution consists of two phases. In the first phase, the minimum sub‐channels are allocated to the macrocell to satisfy their data rate requirements. This problem is mapped to the 0‐1 Knapsack Problem and solved by integer programming based Lagrange dual approach. In the second phase, the redundant sub‐channels are allocated to D2D pairs to maximize the throughput of D2D networks. An interference management scheme is proposed to guarantee the outage probability of D2D communications. A cluster is taken as the unit for frequency reuse among D2D pairs. The problem of clustering is mapped to the MAX k‐CUT problem in graph theory and is solved by graph‐based heuristic algorithm. Extensive simulations demonstrate the superior performance of the proposed solution compared with the existing scheme. Copyright © 2014 John Wiley & Sons, Ltd.
Effects of human apolipoprotein E isoforms on the amyloid β‐protein concentration and lipid composition in brain low‐density membrane domains

Apolipoprotein E4 (apoE4) encoded by ε4 allele is a strong genetic risk factor for Alzheimer’s disease (AD). ApoE4 carriers have accelerated amyloid β‐protein (Aβ) deposition in their brains, which may account for their unusual susceptibility to AD. We hypothesized that the accelerated Aβ deposition in the brain of apoE4 carriers is mediated through cholesterol‐enriched low‐density membrane (LDM) domains. Thus, the concentrations of Aβ and various lipids in LDM domains were quantified in the brains of homozygous apoE3 and apoE4 knock‐in (KI) mice, and in the brains of those mice bred with β‐amyloid precursor protein (APP) transgenic mice (Tg2576). The Aβ40 and Aβ42 concentrations and the Aβ42 proportions in LDM domains did not differ between apoE3 and apoE4 KI mice up to 18 months of age. The Aβ40 concentration in the LDM domains was slightly, but significantly higher in apoE3/APP mice than in apoE4/APP mice. The lipid composition of LDM domains was modulated in an apoE isoform‐specific manner, but its significance for Aβ deposition remains unknown. These data show that the apoE isoform‐specific effects on the Aβ concentration in LDM domains do not occur in KI mouse models.
Language and the prehistory of North America

Abstract This paper addresses some of the problems involved in correlating a language spoken in the past with a particular archaeological site or geographical location, within the context of North America. It discusses both the values and limitations of linguistic data in attempting to assign a language to a particular location in prehistoric times or arrive at archaeological site/language correlations. Speculations regarding the area in which the ancestral forms of specific languages or language families were spoken, and procedures available to linguists and archaeologists in determining earlier residence of a linguistic group, are presented and discussed. The presentation and analysis of evidence bearing on the language group inhabiting a specific North American archaeological site, the Cape Alava or Ozette site in the state of Washington, concludes the paper.
Plasticity of mandibular biomineralization in myostatin‐deficient mice

Compared with the normal or wild‐type condition, knockout mice lacking myostatin (Mstn), a negative regulator of skeletal muscle growth, develop significant increases in relative masticatory muscle mass as well as the ability to generate higher maximal muscle forces. Wild‐type and myostatin‐deficient mice were compared to assess the postweaning influence of elevated masticatory loads because of increased jaw‐adductor muscle and bite forces on the biomineralization of mandibular cortical bone and dental tissues. Microcomputed tomography (microCT) was used to quantify bone density at a series of equidistant external and internal sites in coronal sections for two symphysis and two corpus locations. Discriminant function analyses and nonparametric ANOVAs were used to characterize variation in biomineralization within and between loading cohorts. Multivariate analyses indicated that 95% of the myostatin‐deficient mice and 95% of the normal mice could be distinguished based on biomineralization values at both symphysis and corpus sections. At the corpus, ANOVAs suggest that between‐group differences are due to the tendency for cortical bone mineralization to be higher in myostatin‐deficient mice, coupled with higher levels of dental biomineralization in normal mice. At the symphysis, ANOVAs indicate that between‐group differences are related to significantly elevated bone‐density levels along the articular surface and external cortical bone in the knockout mice. Both patterns, especially those for the symphysis, appear because of the postweaning effects of increased masticatory stresses in the knockout mice versus normal mice. The greater number of symphyseal differences suggest that bone along this jaw joint may be characterized by elevated plasticity. Significant differences in bone‐density levels between normal and myostatin‐deficient mice, coupled with the multivariate differences in patterns of plasticity between the corpus and symphysis, underscore the need for a comprehensive analysis of the plasticity of masticatory tissues vis‐à‐vis altered mechanical loads. J. Morphol. , 2007. © 2007 Wiley‐Liss, Inc.
The Development of Highly Reliable and Efficient Scroll Compressors

In the air conditioning and refrigerant systems, there is a demand for compressor that endure any external variables and save the energy for the earth environment. The newly developed scroll compressor that mainly used for commercial and industrial air conditioners can handle the liquid returning and dilution of lubricant. As for the improvement in efficiency we detected a new asymmetric scroll shape, low distortion fixed scroll and suitable radial compliance mechanism. We succeeded to develop the highly reliable and efficient scroll compressor that is available for R22 and R407C only by exchanging the lubricant, mineral oil and polyvinyl ether. This paper presents the problems encountered during the development of these new compressors and solutions employed to deal with them. L INTRODUCTION Rarely air conditioning and refrigerant compressors will be used under a unusual conditions, such as liquid compression caused by liquid returning, much diluted of lubricating oil, and oilless running. In addition, there are also two problems, associated with the use of new environmentally safe refrigerants HFC. The one is a decrease in the theoretical COP. At the normal condition, the input power of R407C is about 7% larger than that ofR22 though the capacity of them is much the same. The other one is a decline in the reliability of the sliding parts. It has been widely reported that the condition of lubricating can be severed since HFC does not contain chlorine in its molecular structure.l21 The purpose of the development is to solve the fore-mentioned problems.
Using bug report as a software quality measure: an empirical study

Bug reporting systems, such as Bugzilla are online tools used in software development and maintenance to store and track the status of a bug report. They are widely used by both open-source software projects and commercial software companies and have become a major source to study software evolution, software project management, and software quality control. In some research studies, the number of bug reports has been used as an indicator of software quality. This paper examines this representation. We investigate whether the number of bug reports of a specific version of a software product is correlated with its quality. Our study is performed on six branches of three open-source software systems. Our results do not support using the number of bug reports as a quality indicator of a specific version of an evolving software product. Instead, the study reveals that the number of bug reports is in some ways correlated with the time duration between product releases. Finally, the paper suggests a future research to study whether accumulated bug reports can be used as a means to represent the quality of a software branch.