Miracle-dz/UniFAR-FTUs huggingface dataset:
Changes in growth pattern of human squamous‐cell carcinomas of the head and neck during serial passages in nude mice

Six human squamous‐cell carcinomas of the head and neck heterotransplanted to nude mice were studied with respect to changes in tumour volume doubling time (DT), cell cycle phase distribution and clonal composition during serial passages. The tumours exhibited a statistically significant decrease in DT between the first and third or fourth passages towards a constant value. The changes in DT are likely to depend on a reduction of cell loss factor. Five of the original tumours and serially passed heterotransplants were analyzed with flow cytometry. Two tumours were diploid and remained so after heterotransplantation. Three tumours had one diploid and one aneuploid cell population. At heterotransplantation there was a selection of clones and only the aneuploid cell populations could be recovered from the heterotransplants in the first as well as in later passages.
Performance evaluation of tap selection based MMSE equalization for UWB systems

: In this work, the performance of a tap selection based Minimum Mean Square Error (MMSE) equalization technique for high data rate Ultra Wideband (UWB) systems is evaluated for the ﬁrst time using greedy method. This technique is shown to signiﬁcantly outperform the conventional uniformly spaced equalizer with the same number of taps. In addition, the performance of strongest paths based tap selection method is compared with the greedy method. Larger performance gap is observed in the presence of Multiple Access Interference (MAI) and with increased SNR.
Transferts de masse et de chaleur dans les milieux poreux déformables non saturés : application au pressage du papier

Le premier chapitre est consacre a la modelisation du pressage humide. Apres avoir analyse la consolidation d'une feuille de papier lors de sa fabrication, les equations de l'equilibre et de conservation de la matiere sont introduites en precisant les lois de comportement mecanique et de filtration en milieu poreux deformable non sature. La modelisation de la pression capillaire est validee par des essais de prosimetrie au mercure. Les permeabilites relatives en sont deduites. Afin de prendre en consideration la temperature, dans le deuxieme chapitre, la structure de l'equation de conservation de l'energie est obtenue par la methode des developpements asymptotiques a partir de la description physique des transferts thermiques a l'echelle des pores. Le troisieme chapitre est consacre a l'etude du changement de phase dans les milieux poreux. La structure de l'equation thermique macroscopique est decrite en fonction de parametres adimensionnels. Enfin, dans le quatrieme et dernier chapitre, des resultats de simulations numeriques concernant le pressage a chaud sont presentes. Un exemple permet de montrer comment elles peuvent conduire a des solutions techniques originales pour l'amelioration de la productivite des machines a papier au niveau des presses
Carbohydrate Utilization Patterns for the Extremely Thermophilic Bacterium Caldicellulosiruptor saccharolyticus Reveal Broad Growth Substrate Preferences

ABSTRACT Coutilization of hexoses and pentoses derived from lignocellulose is an attractive trait in microorganisms considered for consolidated biomass processing to biofuels. This issue was examined for the H2-producing, extremely thermophilic bacterium Caldicellulosiruptor saccharolyticus growing on individual monosaccharides (arabinose, fructose, galactose, glucose, mannose, and xylose), mixtures of these sugars, as well as on xylan and xylogluco-oligosacchrides. C. saccharolyticus grew at approximately the same rate (td, ∼95 min) and to the same final cell density (1 × 108 to 3 × 108 cells/ml) on all sugars and sugar mixtures tested. In the monosaccharide mixture, although simultaneous consumption of all monosaccharides was observed, not all were utilized to the same extent (fructose > xylose/arabinose > mannose/glucose/galactose). Transcriptome contrasts for monosaccharide growth revealed minimal changes in some cases (e.g., 32 open reading frames [ORFs] changed ≥2-fold for glucose versus galactose), while substantial changes occurred for cases involving mannose (e.g., 353 ORFs changed ≥2-fold for glucose versus mannose). Evidence for catabolite repression was not noted for either growth on multisugar mixtures or the corresponding transcriptomes. Based on the whole-genome transcriptional response analysis and comparative genomics, carbohydrate specificities for transport systems could be proposed for most of the 24 putative carbohydrate ATP-binding cassette transporters and single phosphotransferase system identified in C. saccharolyticus. Although most transporter genes responded to individual monosaccharides and polysaccharides, the genes Csac_0692 to Csac_0694 were upregulated only in the monosaccharide mixture. The results presented here affirm the broad growth substrate preferences of C. saccharolyticus on carbohydrates representative of lignocellulosic biomass and suggest that this bacterium holds promise for biofuel applications.
Local Anaesthesia in Dentistry- Lignocaine too Good or Articaine the Best?

Local anaesthesia is key to painless dental surgical, endodontic and operative procedures. Lignocaine is the gold standard for pain management in dentistry since ages. But, articaine is more potent than lignocaine in attaining infiltration local anaesthesia with low toxicity. Currently, articaine is extensively utilized in dentistry however infrequently used in children. Nevertheless, for selection of local anaesthetic; potency, latency, and duration of anaesthetic effect, pharmacokinetics and toxicity of anaesthetics should be evaluated. Therefore, we will discuss whether “lignocaine is too good or articaine is the best” to accomplish complete pain control with safety and efficacy.
Direct evidence for antifreeze glycoprotein adsorption onto an ice surface

Aqueous solutions of antifreeze glycoproteins (AFGP) exhibit hysteresis between the freezing and melting temperatures. Several recent studies on the mechanism of function of this protein system suggest that a likely model is for the antifreeze molecules to be adsorbed onto the surface of the crystals. However, direct proof of the presence of adsorbed AFGP has eluded previous researchers. In the present study, enhanced surface second‐harmonic generation (SSHG) was observed in the presence of an active AFGP solution in contact with a pure single crystal of ice. The enhancement of SSHG is a positive indication that active AFGP molecules adsorb to the surface of ice crystals.
Regeneration of axons from adult rat retinal ganglion cells on cultured schwann cells is not dependent on basal lamina

The ability of sciatic nerve grafts to support in vivo regeneration of retinal ganglion cell axons in the adult rat raises the question of which peripheral nerve constituents may be required to promote this unexpected central regenerative response. Prime candidates for this role include the surface of the Schwann cell and components of extracellular matrix present in peripheral nerve trunks. To determine the relative importance of Schwann cells and their basal lamina in promoting retinal ganglion cell axon regeneration in the mammalian visual system, we have used an in vitro model. This approach allowed analysis of the abilities of defined peripheral nerve constituents to promote in vitro outgrowth of neurites from explants of adult rat retina harvested 7 to 10 days after in vivo optic nerve crush. Neurite outgrowth was assessed by neurofilament immunofluorescence after 3 to 20 days in vitro. Culture substrata, consisting of isolated Schwann cells (SC), Schwann cells with their assembled extracellular matrix (SC + ECM), or isolated extracellular matrix from which the Schwann cells had been removed (ECM), were prepared by first co‐culturing rat Schwann cells with embryonic dorsal root ganglion neurites on a layer of type I collagen, and then manipulating the cultures to produce the desired substrata. Type I collagen alone did not support neurite growth from adult rat retina. SC and SC + ECM supported regeneration of axons from retinal explants at average growth rates of 18 and 30 μm/h, respectively. Isolated ECM was a poor substrate for retinal neurite growth; the few neurites that gained access to this material grew at rates averaging less than 3 μm/h. These observations suggest that regeneration of adult mammalian retinal ganglion cell axons through peripheral nerve grafts (in vivo) is primarily dependent on neurite‐promoting factors present on the surface of Schwann cells and does not require organized extracellular matrix.
Using Word Embeddings to Translate Named Entities

In this paper we investigate the usefulness of neural word embeddings in the process of translating Named Entities (NEs) from a resource-rich language to a language low on resources relevant to the task at hand, introducing a novel, yet simple way of obtaining bilingual word vectors. Inspired by observations in (Mikolov et al., 2013b), which show that training their word vector model on comparable corpora yields comparable vector space representations of those corpora, reducing the problem of translating words to finding a rotation matrix, and results in (Zou et al., 2013), which showed that bilingual word embeddings can improve Chinese Named Entity Recognition (NER) and English to Chinese phrase translation, we use the sentence-aligned English-French EuroParl corpora and show that word embeddings extracted from a merged corpus (corpus resulted from the merger of the two aligned corpora) can be used to NE translation. We extrapolate that word embeddings trained on merged parallel corpora are useful in Named Entity Recognition and Translation tasks for resource-poor languages.
Constraints on the Majoron interactions from the supernova SN1987A.

The energy release from supernovas via the emission of Majoron-like particles is considered to obtain a constraint on the Yukawa couplings with neutrinos. In view of the observed neutrino flux from the supernova SN1987A, a forbidden region of the Yukawa coupling, 2 x 10/sup -5/
Identification and characterization of a novel Tre‐2/Bub2/Cdc16 (TBC) protein that possesses Rab3A‐GAP activity

The Tre‐2/Bub2/Cdc16 (TBC) domain is a conserved protein motif that consists of approximately 200 amino acids and is thought to function as a specific Rab‐GAP domain. Although more than 40 distinct TBC domain‐containing proteins have been identified in humans, the GAP activity and specificity of most TBC proteins have never been determined. In this study we developed a novel method of screening for Rab3A‐GAP and identified two TBC proteins (FLJ13130 and RN‐tre) whose expression in PC12 cells was associated with exclusion of endogenous Rab3A molecules from dense‐core vesicles. As expression of RN‐tre caused fragmentation of the Golgi, which presumably resulted in the loss of dense‐core vesicles themselves, we further characterized FLJ13130 as a candidate Rab3A‐GAP. The results showed that expression of FLJ13130, but not of its catalytically inactive R134K mutant, greatly reduced the amount of GTP‐Rab3A in living cells and promoted the GTPase activity of Rab3A in vitro. Unexpectedly, however, FLJ13130 also promoted the GTPase activity of Rab22A, Rab27A, and Rab35, but not of Rab2A or Rab6A. Based on these results, we propose that FLJ13130 is a novel type of Rab‐GAP that exhibits broad GAP specificity and inactivates several distinct Rab isoforms, including Rab3A, just near the plasma membrane.
Le marché des obligations privées à la bourse de Paris au 19ème siècle : performance et efficience d'un marché obligataire

L’objet de cette these est d’analyser d’un point de vue financier la cotation et le comportement des obligations privees a la Bourse de Paris a partir de 1838 jusqu’a l’eclatement de la Premiere Guerre mondiale. Cette etude est divisee en deux parties : La premiere relate la creation et l’evolution des emissions obligataires (marche primaire) durant le 19eme siecle. On s’interesse aux grands emetteurs qui ont su se servir le mieux des obligations et les raisons de leur succes. Dans cette partie seront egalement traitees les caracteristiques techniques et les innovations financieres des emissions. La deuxieme partie tente d’analyser le comportement boursier des obligations(marche secondaire). Pour cela un indice general des cours d’obligations durant le 19eme siecle a ete calcule. En se basant sur cet indice nous mettons en lumiere pour la premiere fois, les caracteristiques de ce marche (rentabilite, volatilite, …). Cela permet de comparer nos resultats avec ceux des etudes anterieures sur les marches d’actions et de la rente au 19eme siecle. Cet indice permet egalement de tester les diverses hypotheses financieres relevant de la theorie financiere moderne (efficience informationnelle, cointegration avec des autres compartiments du marche,…).
Job shop scheduling based on ACO with a hybrid solution construction strategy

This paper presents a novel ant colony optimization (ACO) based on an efficient solution construction strategy (transition operator) for improving the quality of the end results of job shop scheduling problem (JSSP). Inspired by the observation that the quality of the end results of ACO is largely affected by their operators — especially the transition operator, a novel solution construction strategy is presented in this paper. The proposed algorithm uses two different strategies to compute the probability of solution construction to improve the end results. Our experimental results show that the proposed algorithm outperforms all state-of-the-art job shop scheduling algorithms evaluated in this paper and can significantly improve the quality of ant colony optimization for JSSP.
Acceleration of Tooth Movement during Orthodontic Treatment-A Frontier in Orthodontics

Aim: The purpose of this review is to view the successful approaches in accelerated tooth movement and to highlight the newest technique in tooth movement. Background: Orthodontics has been developing greatly in achieving the desired results both clinically and technically.Continous modification of wires and brackets as a result of bio mechanical efficiencies in orthodontics has greatly improved.However,these biomechanical systems may have reached their limit and their is a need to develop new methods to accelerate teeth movement.It is still very challenging to reduce the duration of orthodontic treatments.It is one of the common deterrents that orthodontist faces and causes irritation among adults and increasing risks of caries,gingival recession and root resorption.A lot of approaches have been done to achieve quicker results,but still there are some uncertainties towards most of the techniques.The purpose of this review is to view the successful approaches in accelerated tooth movement and to highlight the newest technique in tooth movement.
A CT sign of chronic pulmonary arterial hypertension: the ratio of main pulmonary artery to aortic diameter.

The aim of this study was to determine whether the ratio of the diameters of the main pulmonary artery and of the ascending aorta (rPA), as assessed on computed tomography (CT), is predictive of pulmonary arterial hypertension (PAH). We undertook a retrospective review of 50 patients with a wide range of pulmonary and cardiovascular diseases, who had undergone both chest CT and pulmonary arterial pressure measurements at right heart catheterization. Two independent observers made measurements of the diameter of the main pulmonary artery and of the ascending aorta on a single defined CT section. Body surface area (BSA, n = 48), pulmonary arteriolar resistance (n = 39), total lung capacity (n = 40), and aortic pressures (n = 50) were also recorded. rPA and pulmonary arterial diameter (dPA) were positively related to mean pulmonary artery pressure (Rs = 0.74, p < 0.0005 for both analyses). For patients younger than 50 years of age, mean pulmonary artery pressure correlated more strongly with rPA than dPA (Rs = 0.77, p < 0.00005, compared with Rs = 0.59, p < 0.005); and vice versa for patients older than 50 years of age (Rs = 0.63, p < 0.005, compared with Rs = 0.75, p < 0.00005). Using a mean pulmonary artery pressure greater than 20 mm Hg as indicative of PAH and a value of rPA > 1, the sensitivity, specificity, and positive and negative predictive values for determining PAH were 70% (26/37), 92% (12/13), 96% (26/27), and 52% (12/23), respectively. On multivariate analysis, rPA was positively related to mean pulmonary artery pressure (p < 0.0005), and negatively related to age (p < 0.0005), but was not related to BSA. By contrast, dPA showed some dependency on BSA (p < 0.0005), as well as on mean pulmonary arterial pressure. In patients younger than 50 years of age, we have found a strong correlation between rPA and mean pulmonary artery pressure in a heterogeneous study population, and this relationship is independent of BSA and sex. The presence of the sign "rPA > 1" is simple in practical CT reading to determine; if this is identified, there is a very high probability of pulmonary arterial hypertension, and clinicians should be alerted to this possibility.
Damping ratio estimation of Three-Phase Induction Motor

Three-Phase Induction Motors are both electrical and mechanical structures. In this paper an analysis from mechanical point of view is done. The modal parameters, natural frequencies, modal shapes, damping ratio, modal masses describe in the whole the modal behaviour of a mechanical structure. For a better design in dynamic analysis and a decreasing the vibration and noise levels it is necessary to be known the damping ratio. This internal modal parameter can be found only by experimental data. The present paper describes a possible solution of defining mathematical functions of damping ratio vs. frequencies based on experimental modal analysis.
Genome Sequence of Bacillus licheniformis CGMCC3963, a Stress-Resistant Strain Isolated in a Chinese Traditional Solid-State Liquor-Making Process

ABSTRACT Bacillus licheniformis CGMCC3963 is an important mao-tai flavor-producing strain. It was isolated from the starter (Daqu) of a Chinese mao-tai-flavor liquor fermentation process with solid-state fermentation. We report its genome of 4,525,096 bp here. Many potential insertion genes that are responsible for the unique properties of B. licheniformis CGMCC3963 in mao-tai-flavor liquor production were identified.
Specialist palliative care in nonmalignant disease

The objective of this study was to investigate how many patients who die from causes other than cancer might benefit from specialist palliative care. This was achieved by secondary analysis of data from the Regional Study of Care for the Dying, a retrospective national population-based interview survey. The investigation involved 20 self-selected English health districts, nationally representative in terms of social deprivation and most aspects of health services provision. A total of 3696 patients were randomly selected from death registrations in the last quarter of 1990; an interview concerning the patient was completed 10 months after the death by bereaved family, friends or officials. The results show that a third (243/720) of cancer patients who were admitted to hospices or had domiciliary palliative care scored at or above the median on three measures of reported symptom experience in the last year of life. That is the number of symptoms (eight or more), the number of distressing symptoms (three or more) and the number of symptoms lasting more than six months (three or more). A total of 269 out of 1605 noncancer patients (16.8%) fulfilled these criteria. On this basis, it is estimated that 71 744 people who die from nonmalignant disease in England and Wales each year may require specialist palliative care. An increase of at least 79% in caseload would, therefore, be expected if specialist palliative care services were made fully available to noncancer patients. This is a conservative estimate, as non-cancer patients were matched to only one-third of cancer patients who had specialist palliative care. It is concluded that clinicians and patient groups caring for patients with advanced nonmalignant disease must work together with specialist palliative care services and with health commissioners to develop, fund and evaluate appropriate, cost-effective services which meet patient and family needs for symptom control and psychosocial support.
Desirable pharmacokinetic properties of 13C-uracil as a breath test probe of gastric emptying in comparison with 13C-acetate and 13C-octanoate in rats

Objective. To investigate the possible use of a 13C-uracil breath test for gastric emptying by evaluating the pharmacokinetic properties of 13C-uracil in a breath test in rats, in comparison with 13C-acetate and 13C-octanoate, traditional 13C-probes for gastric emptying. Material and methods. Absorption of the 13C-probes from different parts of the gastrointestinal tract was evaluated in fasted rats. 13C-Uracil breath tests for gastric emptying were carried out in conditions where delayed gastric emptying was induced by clonidine, quinpirole, and propantheline, and in a postoperative ileus model. Following oral administration, we measured residual 13C-uracil in the stomach and correlated the amount with the breath response. Results. All the 13C-probes employed were well absorbed from the intestine after intraduodenal administration. After intragastric administration, 13C-uracil was not absorbed from the stomach, but 13C-acetate and 13C-octanoate were partly absorbed from the stomach. The cumulative 14C-uracil recovery (%) at 168 h was 92.3, 6.3, or 0.5%, from expired gases, urine, and feces, respectively. Δ13C values in 13C-uracil breath tests were decreased in conditions characterized by delayed gastric emptying. A highly negative correlation was observed between the breath response and the residual ratio of 13C-uracil in the stomach after oral administration of 13C-uracil, indicating that 13C-uracil can be used as an in vivo probe for evaluating gastric emptying in a quantitative manner. Conclusions. This study showed that 13C-uracil has desirable pharmacokinetic properties as an in vivo probe of gastric emptying. It is thus suggested that the 13C-uracil breath test may be useful for the measurement of gastric emptying in humans.