Miracle-dz/UniFAR-FTUs huggingface dataset:
Ensembles of Text and Time-Series Models for Automatic Generation of Financial Trading Signals from Social Media Content

Abstract Event studies in finance have focused on traditional news headlines to assess the impact an event has on a traded company. The increased proliferation of news and information produced by social media content has disrupted this trend. Although researchers have begun to identify trading opportunities from social media platforms, such as Twitter, almost all techniques use a general sentiment from large collections of tweets. Though useful, general sentiment does not provide an opportunity to indicate specific events worthy of affecting stock prices. This work presents an event clustering algorithm, utilizing natural language processing techniques to generate newsworthy events from Twitter, which have the potential to influence stock prices in the same manner as traditional news headlines. The event clustering method addresses the effects of pre-news and lagged news, two peculiarities that appear when connecting trading and news, regardless of the medium. Pre-news signifies a finding where stock prices move in advance of a news release. Lagged news refers to follow-up or late-arriving news, adding redundancy in making trading decisions. For events generated by the proposed clustering algorithm, we incorporate event studies and machine learning to produce an actionable system that can guide trading decisions. The recommended prediction algorithms provide investing strategies with profitable risk-adjusted returns. The suggested language models present annualized Sharpe ratios (risk-adjusted returns) in the 5–11 range, while time-series models produce in the 2–3 range (without transaction costs). The distribution of returns confirms the encouraging Sharpe ratios by identifying most outliers as positive gains. Additionally, machine learning metrics of precision, recall, and accuracy are discussed alongside financial metrics in hopes of bridging the gap between academia and industry in the field of computational finance.
On improving time range measurements for ISM nodes location

The paper is discussing some aspects of providing location in wireless ISM bands networks. Particularly, the focus is on precision time stamping of messages needed to compute the location based on the information about time difference of arrival of signal from a mobile node to multiple fixed nodes with known positions. After presenting the particularities of such networks that influence ranging, solutions are given to increase accuracy along with practical results. Also, the paper contains application extension to other networks regardless their protocols or carrier signal modulation.
Serum CA 125 as a Prognostic Factor in Non-Hodgkin's Lymphoma

Cancer antigen 125 (CA 125) is a glycoprotein expressed in normal tissues originally derived from coelomic epithelia such as peritoneum, pleura, pericardium, fallopian tubes and endometrium. Serum CA 125 levels are elevated in various benign and malignant conditions that involve stimulation of these tissues. Although elevated levels have been reported in patients with non-Hodgkin's lymphoma (NHL), its role as a prognostic factor remained uncertain. In this study, serum CA 125 levels were measured prospectively in 108 consecutive patients with NHL: at diagnosis in 106, in remission in 39 and at relapse in 7. Levels were elevated in 43% at diagnosis. This finding was associated with advanced disease stage, bulky tumors, bone marrow involvement, extranodal disease (in stages III and IV), occurrence of B symptoms, pleural or peritoneal effusions, high serum LDH levels, high serum β2 microglobulin (β2-M) levels, elevated International Prognostic Score, poor performance status and partial or no response to treatment. No difference in CA 125 level was found between the indolent and aggressive lymphomas. Serum CA 125 levels at diagnosis had strong association with event-free and overall survival (<formula><italic>p</italic>=0.01</formula> and 0.003, respectively), with the patients with increased levels having worse survival. Patients with high CA 125 levels at diagnosis who achieved remission showed a significant decrease in CA 125 levels in remission. In conclusion, CA 125 is not only a reliable marker for staging and assessing tumor activity in NHL, elevated levels are also predictive of decreased survival.
FDI Spillovers on Corporate Social Responsibility: The Channel of Labor Mobility

This paper examines the spillover effects of foreign direct investment on corporate social responsibility of domestic firms, with a focus on the channel of labor mobility. With a corporate social responsibility measure based on corporate responsibility toward the environment, the public, the employees, and the consumers, we test whether and how foreign direct investment affects corporate social responsibility of Chinese firms. Our results show that firms run by entrepreneurs who have work experience and, especially, management experience in multinational enterprises investing in China conduct more corporate social responsibility activities compared with firms run by entrepreneurs without such experience. We further find that multinational enterprise management experience may enhance the entrepreneurial self-assessment of social status, broaden the international vision of entrepreneurs, and reduce the level of firm family control, which help increase firms’ uptake of corporate social responsibility activities. Our results suggest that foreign direct investment can serve as a vehicle for sustainable development, through the transfer of corporate social responsibility-related managerial knowledge from foreign to local firms.
The effect of age on the response of the detrusor to intracellular mechanical stimulus: DNA replication and the cell actin matrix

Benign prostatic hypertrophy and posterior urethral valves present at both extremes of the age spectrum. Both disease processes can obstruct the urinary stream and ultimately have pathophysiological effects on detrusor structure and function. The mechanisms regulating the structural reorganization of the detrusor to a mechanical outflow obstruction are not known. In an attempt to identify maturational differences in myoctyte ultrastructure and consequent effects these might have in modifying the response of the destrusor to mechanical stimulus, we studied differences in dyanmic nuclear‐cytoskeletal interactions in detrusor tissue in an animal model. Using a drug which spcifically severs actin, cytochalasin D (CD), as an intracellular mechanical stimulus, we measured changes in nuclear area and the rate of DNA synthesis in detrusor myocytes from young (2–3 wee) and old (8–12 mon) guinea pgis. We found that there were age specific differences to intracellular mechanical stimuli in detrusor muscle. Nuclei of myocytes from young animals showed elastic recoil on severing the cell actin matrix and the tissue from young animals increased replicative DNA synthesis with an intracelluar stimulus. In contrast, nuclear shape changes in myocytes from old animals suggested less elasticity, and there was no increase in DNA synthesis with disruption of the cell actin matrix. Anti‐α‐smooth muscle actin antibody and rhodamine phalloidin staining of actin in cytochalasin D treated primary explants of detrusor mycocytes showed dose dependent disruption of the actin component of the cytoskeleton.
A Decision Aid for Women Considering Neoadjuvant Systemic Therapy for Operable Invasive Breast Cancer: Development and Protocol of a Phase II Evaluation Study (ANZ1301 DOMINO)

Background Neoadjuvant systemic therapy is offered to selected women with large and/or highly proliferative operable breast cancers. This option adds further complexity to an already complex breast cancer treatment decision tree. Patient decision aids are an established method of increasing patient involvement and knowledge while decreasing decisional conflict. There is currently no decision aid available for women considering neoadjuvant systemic therapy. Objective We aimed to develop a decision aid for women diagnosed with operable breast cancer and considered suitable for neoadjuvant systemic therapy, and the protocol for a multicenter pre-post study evaluating the acceptability and feasibility of the decision aid. Methods The decision aid was developed through literature review, expert advisory panel, adherence to the International Patient Decision Aid Standards, and iterative review. The protocol for evaluation of the decision aid consists of the following: eligible women will undertake a series of questionnaires prior to and after using the decision aid. The primary endpoint is decision aid acceptability to patients and investigators and the feasibility of use. Secondary endpoints include change in decisional conflict, participant knowledge, and information involvement preference. Feasibility is defined as the proportion of eligible participants who use the decision aid to help inform their treatment decision. Results This study has recruited 29 out of a planned 50 participants at four Australian sites. A 12-month recruitment period is expected with a further 12-months follow-up. Conclusions The decision aid has the potential to allow patients with operable breast cancer, who have been offered neoadjuvant systemic therapy, decreased decisional conflict, and greater involvement in the decision. If this study finds that an online decision aid is feasible and acceptable, it will be made widely available for routine clinical practice. Trial Registration Australian and New Zealand Clinical Trials Registry ACTRN12614001267640; http://www.anzctr. org.au/TrialSearch.aspx? searchTxt=ACTRN12614001267640&isBasic=True (Archived by WebCite at http://www.webcitation.org/6gh7BPZdG)
Etoposide‐initiated MLL rearrangements detected at high frequency in human primitive hematopoietic stem cells with in vitro and in vivo long‐term repopulating potential

Rearrangements initiating within the well‐characterized break‐point cluster region of the mixed lineage leukemia (MLL) gene on 11q23 are a hallmark of therapy‐related leukemias following treatment with topoisomerase II poisons including etoposide. Hematopoietic stem cells (HSC) are believed to be the target cell for leukemia‐initiating MLL rearrangement events. Although etoposide treatment is sufficient to induce readily detectable MLL rearrangements in primary human CD34+ cells, the majority of cells that gain translocations do not proliferate in culture possibly due to reduced proliferative capacity of most CD34+ cells during normal differentiation [Blood 2005;105:2124]. We characterized the impact of etoposide on primary human long‐term repopulating HSC that represent only a minor portion of CD34+ cells. The proliferative capacity of HSC is dramatically increased following both a single and multiple exposures to etoposide as determined by their ability to engraft bone marrow of immune‐deficient non‐obese diabetic/severe combined immunodeficient mice and to initiate hematopoiesis in long‐term initiating cultures. Similar to results in CD34+ cells, a significant proportion of etoposide‐treated HSC‐derived clones harbored stable MLL rearrangements, including duplications, inversions and translocations. These results indicate HSC are highly susceptible to etoposide‐induced and potentially oncogenic rearrangements initiating within MLL, and these HSC are particularly proficient for continued long‐term proliferation both in vivo and in vitro.
Nondisruptive detection of activity of catabolic promoters of Pseudomonas putida with an antigenic surface reporter system

A simple procedure to detect the switching on and off of catabolic promoters of Pseudomonas putida, at the level of single cells based on the immunodetection of a reporter epitope expressed on the surface of bacterial cells, has been developed. To do this, the antigenic sequence Asp-Leu-Pro-Pro-Asn-Ser-Asp-Val-Val-Asp, from a coronavirus, was inserted genetically in the permissive site around amino acid position 153 of the LamB protein (maltose and lambda phage receptor) of Escherichia coli. When the hybrid lamB gene is transcribed, the epitope becomes presented on the surface of the bacterial cells in a configuration available to specific antibodies. To validate this notion in nonenteric bacteria, the expression and correct processing of LamB were confirmed by coupling the lamB gene to the salicylate-responsive Psa1 promoter of the NAH7 (naphthalene degradation) plasmid in Pseudomonas putida. Subsequently, a hybrid lamB gene carrying the sequence of the coronavirus antigen was placed downstream of the m-toluate-responsive Pm promoter of the TOL (toluene degradation) plasmid. Exposure of the epitope on the Pseudomonas cell surface was monitored through fluorescence of whole cells treated with a monoclonal antibody against the heterologous antigen. Fluorescence emission was dependent on the presence of m-toluate in the medium, thus permitting detection of the Pm promoter switching on by simple optical inspection of individual cells, even in situations when these are a very minor component of a complex bacterial community.
Analysing the changes of employment subcentres: A comparison study of Houston and Dallas

There is only a sparse empirical literature that examines the emergence and growth of employment centres in large metropolitan areas. And only a few of the available studies analyse the determinants of the growth of centre(s) (and subcentres) over time. There are even fewer studies that compare different metropolitan regions in terms of how their employment centres grow or decay over several decades. This research aims to fill the gap by exploring changes in employment centres for two decades in two large US metropolitan areas of comparable size– Houston and Dallas. It employs 1990 and 2000 Census Transportation Planning Package (CTPP) data and American Community Survey (ACS) 2006–2010 5-year estimates to test factors suggested in the literature as possibly affecting the emergence and growth of employment centres. A revised two-stage minimum cut-off point approach is utilised to identify employment centres. We adopt an OLS model to find the driving forces for job changes in the employment centres of Houston and Dallas. A step-wise regression method is also adopted to find the major contributors to observed changes in job centres. Based on the results, it is possible to identify job changes and also a better understanding of the major factors associated with the changes. The findings are conceivably valuable for urban planners and policy makers to help them understand trends and allocate resources in an informed manner.
Soil moisture estimates on global scale from AMS-RE brightness temperatures

The ability to estimate the soil moisture content on a global scale from dual-frequency (C- and X-bands) microwave AMSR-E data is investigated in this paper. The C-band AMSR-E data were calibrated by comparing AMSR-E data with past measurements of SSM/I and SMMR sensors over some reference targets as the Amazon forest and the Ocean. An algorithm for the retrieval of soil moisture, based on a simplified form of the radiative transfer theory, was tested and subsequently inverted by using the Nelder-Mead method. The algorithm, which used both the brightness temperature at C-band and the polarization index at X-band, was successfully validated on data collected on two areas in Italy and US, during the MASMEx02 and the SMEX02 experiments, respectively
Global enhancement of nuclear localization‐dependent nuclear transport in transformed cells

Fundamental to eukaryotic cell function, nucleocytoplasmic transport can be regulated at many levels, including through modulation of the importin/exportin (Imp/Exp) nuclear transport machinery itself. Although Imps/Exps are overexpressed in a number of transformed cell lines and patient tumor tissues, the efficiency of nucleocytoplasmic transport in transformed cell types compared with nontransformed cells has not been investigated. Here we use quantitative live cell imaging of 3 isogenic nontransformed/transformed cell pairs to show that nuclear accumulation of nuclear localization signal (NLS)‐containing proteins, but not their NLS‐mutated derivatives, is increased up to 7‐fold in MCF10CA1h human epithelial breast carcinoma cells and in simian virus 40 (SV40)‐transformed fibroblasts of human and monkey origin, compared with their nontransformed counterparts. The basis for this appears to be a significantly faster rate of nuclear import in transformed cell types, as revealed by analysis using fluorescence recovery after photobleaching for the human MCF10A/ MCF10CA1h cell pair. Nuclear accumulation of NLS/ nuclear export signal‐containing (shuttling) proteins was also enhanced in transformed cell types, experiments using the nuclear export inhibitor leptomycin B demonstrating that efficient Exp‐1‐mediated nuclear export was not impaired in transformed compared with nontransformed cells. Enhanced nuclear import and export efficiencies were found to correlate with 2‐ to 4‐fold higher expression of specific Imps/Exps in transformed cells, as indicated by quantitative Western blot analysis, with ectopic expression of Imps able to enhance NLS nuclear accumulation levels up to 5‐fold in nontransformed MCF10A cells. The findings indicate that transformed cells possess altered nuclear transport properties, most likely due to the overexpression of Imps/Exps. The findings have important implications for the development of tumor‐specific drug nanocarriers in anticancer therapy. — Kuusisto, H. V. , Wagstaff, K. M. , Alvisi, G. , Roth, D. M. , Jans, D. A. Global enhancement of nuclear localization‐dependent nuclear transport in transformed cells. FASEB J. 26, 1181‐1193 (2012). www.fasebj. org
The VRIO characteristics of corporate strategic human capital at business level

Strategic human capital as the unique resources brings competitive advantages for enterprises, which is unquestionable. Because of different strategies at business level, strategic human capital characteristics are different. This paper, firstly, through exploratory factor analysis surveys the strategies at the business layer of 435 enterprises, two different types of enterprises under the cost leading strategy and product differentiate strategy are implemented respectively; secondly, based on the structural equation theory for two kinds of enterprises it establishes structural equation to analyze and compare the V (value), R (rarity), I (inimitability) and O (organization), the four areas of strategic human capital characteristics; finally, adopting the analysis findings that on the base of not ignoring the value (V) of employees, when take the measure of cost leadership strategy, the corporate strategic human capital better equipped with the rarity (R) and the inimitability (I) characteristics; however with the product differentiation strategy, the corporate strategic human capital characteristics of the rarity(R), the inimitability(1) and the organization(O) are more important.
Engineering Saccharomyces cerevisiae for improvement in ethanol tolerance by accumulation of trehalose

ABSTRACT A genetic recombinant Saccharomyces cerevisiae starter with high ethanol tolerance capacities was constructed. In this study, the gene of trehalose-6-phosphate synthase (encoded by tps1), which catalyzes the first step in trehalose synthesis, was cloned and overexpressed in S. cerevisiae. Moreover, the gene of neutral trehalase (encoded by nth1, trehalose degrading enzyme) was deleted by using a disruption cassette, which contained long flanking homology regions of nth1 gene (the upstream 0.26 kb and downstream 0.4 kb). The engineered strain increased its tolerance against ethanol and glucose stress. The growth of the wild strain was inhibited when the medium contained 6 % or more ethanol, whereas growth of the engineered strain was affected when the medium contained 10 % or more ethanol. There was no significant difference in the ethanol yield between the wild strain and the engineered strain when the fermentation broth contained 10 % glucose (p > 0.05). The engineered strain showed greater ethanol yield than the wild type strain when the medium contained more than 15 % glucose (p < 0.05). Higher intracellular trehalose accumulation by overexpression of tps1 and deletion of nth1 might provide the ability for yeast to protect against environmental stress.
Emissivity Calculation for a Finite Circular Array of Pyramidal Absorbers Based on Kirchhoff's Law of Thermal Radiation

Internal calibration source provides reference data for remote sensing system. Realistic calibration source is constructed by finite periodic structure, and hence, the emissivity calculation is different from the infinite periodic array case. In this paper, conventional indirect method based on the scattering field is modified first, so that it can be used to calculate the emissivities of finite homogeneous objects. Subsequently, a new method based on antenna concept is proposed for calculating the differential scattering coefficients and emissivities of the inhomogeneous finite objects. The methods are then applied to finite circular pyramid arrays covered with an absorbing material, and the results are analyzed. Furthermore, the effect of the illuminating scope of incident wave on the emissivity and differential scattering coefficient of circular finite pyramid array is studied.
Stealth Dicing Challenges for MEMS Wafer Applications

In our digital world, microelectromechanical system (MEMS) are here to stay and will open the doors for the next exciting wave in the advancement of technology such as the Internet of Things (IoT). The MEMS devices in wafer forms are fabricated in minute details and eventually singulated into individual units to act as sensing or actuation elements in various applications such as accelerometer and gyroscopes for navigation, in wireless mobile and smart car applications. Handling of such MEMS device requires overcoming many challenges in both fabrication and assembly. Singulation of MEMS device with fragile and sensitive structures is one of the many assembly challenges. In fact, most devices are capped to protect its active moving components that maybe damaged when using conventional singulation method that is by mechanical dicing wherein water splashes or pressure is unavoidable. With the introduction of stealth laser dicing, where micro damage is created internally and through several layers of this damages creates a propagation to eventually separate the wafer upon forced expansion through tape, it became possible for a dry process singulation without damaging the fragile components. However, stealth dicing leverages on infrared waves being transparent only and able to penetrate through smooth surface silicon wafers and at certain resistivity or level of doping to create internal damage on the work piece. As such, stealth dicing process may have difficulty to handle saw street with metallization, heavily doped or high resistivity wafer as in the case of SOI wafer and deep trenches that may surface in some MEMS devices. This created limitations for MEMS designs, processes and materials selection that may not be limited to the active region alone but as well as on the dicing saw street. In this paper we will conduct stealth dicing study on various types of wafer configuration and thus making a clearer assembly process for next generation of mobile applications and the fast growing market of IoT.