Miracle-dz/UniFAR-FTUs huggingface dataset:
Crystal structure of metagenomic &bgr;-xylosidase/ &agr;-L-arabinofuranosidase activated by calcium

The crystal structure of metagenomic β-xylosidase/α-l-arabinofuranosidase CoXyl43, activated by calcium ions, was determined in its apo and complexed forms with xylotriose or l-arabinose in the presence and absence of calcium. The presence of calcium ions dramatically increases the kcat of CoXyl43 for p-nitrophenyl β-d-xylopyranoside and reduces the Michaelis constant for p-nitrophenyl α-l-arabinofuranoside. CoXyl43 consists of a single catalytic domain comprised of a five-bladed β-propeller. In the presence of calcium, a single calcium ion was observed at the centre of this catalytic domain, behind the catalytic pocket. In the absence of calcium, the calcium ion was replaced with one sodium ion and one water molecule, and the positions of these cations were shifted by 1.3 Å. The histidine-319 side chain, which coordinates to the 2-hydroxyl oxygen atom of the bound xylose molecule in the catalytic pocket, also coordinates to the calcium ion, but not to the sodium ion. The calcium-dependent increase in activity appears to be caused by the structural change in the catalytic pocket induced by the tightly bound calcium ion and coordinating water molecules, and by the protonation state of glutamic acid-268, the catalytic acid of the enzyme. Our findings further elucidate the complex relationship between metal ions and glycosidases.
Determinants of Halal Cosmetics Purchase Intention on Indonesian Female Muslim Customer

The purpose of this research was to analyze partially the influence of attitude, subjective norm, perceived behavioral control, and knowledge towards customer purchase intention. Data were collected through a questionnaire of 200 respondents from Indonesian female Muslim customer. The research used a descriptive and explanatory methods which analyzed by using multiple regression analysis through SPSS software. The results showed there are partially positive and significant influence between attitude, subjective norm, and knowledge towards halal cosmetics purchase intention. Meanwhile, perceived behavioral control has no significant influence on customer purchase intention. These results will be a good recommendation for cosmetics manufacturers in producing and promoting their halal cosmetics product by considering the influence of consumers' attitude, subjective norm and knowledge. This research is expected to be useful for the development of halal cosmetics industry in the future. Research paper Keywords: Theory of planned behavior, purchase intention, knowledge, halal cosmetics Reference to this paper should be made as follows: Haro, A. (2018). Determinants of Halal Cosmetics Purchase Intention on Indonesian Female Muslim Customer, Journal of Entrepreneurship, Business and Economics , 6 (1), 78–91.
Communication with Speech and Gestures: Applications of Recurrent Neural Networks to Robot Language Learning

Recurrent neural networks have recently shown signiﬁcant potential in different language applications, ranging from natural language processing to language modelling. This paper introduces a research effort to use such networks to develop and evaluate natural language acquisition on a humanoid robot. Here, the problem is twofold. First, the focus will be put on using the gesture-word combination stage observed in infants to transition from single to multi-word utterances. Secondly, research will be carried out in the domain of connecting action learning with language learning. In the former, the long-short term memory architecture will be implemented, whilst in the latter multiple time-scale recurrent neural networks will be used. This will allow for comparison between the two architectures, whilst highlighting the strengths and shortcomings of both with respect to the language learning problem. Here, the main research efforts, challenges and expected outcomes are described.
The 2018 Power Trading Agent Competition

This is the specification for the Power Trading Agent Competition for 2018 (Power TAC 2018). Power TAC is a competitive simulation that models a “liberalized” retail electrical energy market, where competing business entities or “brokers” offer energy services to customers through tariff contracts, and must then serve those customers by trading in a wholesale market. Brokers are challenged to maximize their profits by buying and selling energy in the wholesale and retail markets, subject to fixed costs and constraints; the winner of an individual “game” is the broker with the highest bank balance at the end of a simulation run. Costs include fees for publication and withdrawal of tariffs, and distribution fees for transporting energy to their contracted customers. Costs are also incurred whenever there is an imbalance between a broker’s total contracted energy supply and demand within a given time slot. The simulation environment models a wholesale market, a regulated distribution utility, and a population of energy customers, situated in a real location on Earth during a specific period for which weather data is available. The wholesale market is a relatively simple call market, similar to many existing wholesale electric power markets, such as Nord Pool in Scandinavia or FERC markets in North America, but unlike the FERC markets we are modeling a single region, and therefore we approximate locational-marginal pricing through a simple manipulation of the wholesale supply curve. Customer models include households, electric vehicles, and a variety of commercial and industrial entities, many of which have production capacity such as solar panels or wind turbines. All have “real-time” metering to support allocation of their hourly supply and demand to their subscribed brokers, and all are approximate utility maximizers with respect to tariff selection, although the factors making up their utility functions may include aversion to change and complexity that can retard uptake of marginally better tariff offers. The distribution utility models the regulated natural monopoly that owns the regional distribution network, and is responsible for maintenance of its infrastructure. Real-time balancing of supply and demand is managed by a market-based mechanism that uses economic incentives to encourage brokers to achieve balance within their portfolios of tariff subscribers and wholesale market positions, in the face of stochastic customer behaviors and weather-dependent renewable energy sources. Changes for 2018 are focused on stability, on simplifying interaction with the balancing market, and on encouraging more vigorous competition, and are highlighted by change bars in the margins. See Sections 3.1. 2, 6, and 8.5 for details.
Tidal heating and convection in

[1] The prodigious heat flux emitted from the surface of Jupiter’s moon Io is produced in the interior of the satellite by viscoelastic dissipation of tidal energy and is generally thought to be brought to the surface by convective motions. New models of Io’s equilibrium thermal state are constructed using self-consistent calculations of tidal heating and convective heat transport. These models show that while a high-temperature convective equilibrium exists, it falls an order of magnitude short of explaining the observed heat flux. Either Io is currently out of thermal equilibrium, or another heat transport mechanism such as melt segregation determines Io’s thermal state.
Do C-H...O and C-H...pi interactions help to stabilize a non-centrosymmetric structure for racemic 2,3-dibromo-1,3-diphenylpropan-1-one?

The racemic title compound, C15H12Br2O, crystallizes in a non-centrosymmetric structure and displays a significant non-linear optical response to red light. The crystal packing is influenced by C-H.O and C-H.pi interactions. One of the former bonds has a short H.O separation of 2.27 angstroms.
Dissociative role for dorsal hippocampus in mediating heroin self‐administration and relapse through CDK5 and RhoB signaling revealed by proteomic analysis

Addiction is characterized by drug craving, compulsive drug taking and relapse, which is attributed to aberrant neuroadaptation in brain regions implicated in drug addiction, induced by changes in gene and protein expression in these regions after chronic drug exposure. Accumulating evidence suggests that the dorsal hippocampus (DH) plays an important role in mediating drug‐seeking and drug‐taking behavior and relapse. However, the molecular mechanisms underlying these effects of the DH are unclear. In the present study, we employed a label‐free quantitative proteomic approach to analyze the proteins altered in the DH of heroin self‐administering rats. A total of 4015 proteins were quantified with high confidence, and 361 proteins showed significant differences compared with the saline control group. Among them, cyclin‐dependent kinase 5 (CDK5) and ras homolog family member B (RhoB) were up‐regulated in rats with a history of extended access to heroin. Functionally, inhibition of CDK5 in the DH enhanced heroin self‐administration, indicating that CDK5 signaling in the DH acts as a homeostatic compensatory mechanism to limit heroin‐taking behavior, whereas blockade of the Rho‐Rho kinase (ROCK) pathway attenuated context‐induced heroin relapse, indicating that RhoB signaling in the DH is required for the retrieval (recall) of addiction memory. Our findings suggest that manipulation of CDK5 signaling in the DH may be essential in determining vulnerability to opiate taking, whereas manipulation of RhoB signaling in the DH may be essential in determining vulnerability to relapse. Overall, the present study suggests that the DH can exert dissociative effects on heroin addiction through CDK5 and RhoB signaling.
Biopsychosocial approach to treating self-injurious behaviors: an adolescent case study.

TOPIC Self-injurious behaviors (SIBs) are a common coping mechanism in the adolescent population. A marked increase in SIB has been seen in recent years, yet effective treatment remains elusive. PURPOSE This study aims to review current theoretical perspectives and treatment options that reflect a biopsychosocial framework. SOURCES Selected multidisciplinary literature related to SIB. CONCLUSIONS A 6-month multidisciplinary approach targeting the unique physical, emotional, and social needs of a 14-year-old girl in residential treatment led to the complete cessation of SIB.
Probabilistic approach-based wide-area damping controller for small-signal stability enhancement of wind-thermal power systems

Based on wide area measurements obtained by phasor measurement units and probabilistic eigenanalysis, this paper presents an approach to the design of a wide-area supplementary damping controller (WASDC) in order to improve the damping of inter-area oscillatory modes in wind-thermal power systems. Novel probabilistic indexes of controllability and observability are proposed to tackle the selection of proper wide-area input signals and the placement of the WASDC. Parameters of the controller are determined by solving an optimization problem that accounts for small-signal stability performance requirements. Numerical results obtained using a benchmark weak interconnected power system are used to survey the possible impact of wind power on system small-signal stability performance, especially in terms of mode controllability and observability, as well as to demonstrate the effectiveness of the proposed controller.
Competitive Array of Cities Based on the Local DevelopmentStrategy

Competitive advantage and competitiveness are the very goals that any company is subject to having to seek and overcome along the way of their productive or operational activities. With this study, we try to understand the elements of the competitive matrix of cities based on the local development strategy, taking into account an analysis of São Paulo and Rio de Janeiro in 2014. Thus, it became a case study based on a qualitative research in order to find solutions on the raised problem situation. Competitiveness is a key factor in defining the strategies of companies and the way she wants to beat the competition. Widely competitive markets recorded strong economic, social, political and environmental development. However, the matrix is not a static tool, but dynamic depending on the actions of their agents.
The Digital TV as another solution to educate in isolated areas in the Amazon State , Brazil

Several studies show that the distance education is a viable way to offer education to places that have difficulties in access to quality education. In the Amazon State, Brazil, some projects have gained notoriety for their emphasis on providing effective education at various high school and higher education levels in remote cities. We aim at providing mainstream inclusion to people who live in hard-to-reach cities. The aim of this project described in this paper is to investigate alternatives to use an e-learning management system within an interactive digital TV scenario. We plan to use the TIDIA-AE platform, which allows synchronous and asynchronous collaborative distance learning supported, integrated with the interactive digital TV platform under development in Brazil. As a result, we are providing a proof-ofconcept prototype tool to be used by institutions in their educational activities. One of the tasks is the customization of the TIDIA-AE software platform taking into account some requirements for its use in a region as the Amazon, which presents very limited good quality network access. Our proposal takes advantage from the quality of image that TV provides and investigates the advantages of interactive digital TV. The work includes: investigation of the requirements, proposal and evaluation of alternatives, development of the proof-of-concept prototype and experimentation within potential scenarios. The work will be summarized in a report discussing the feasibility of using TIDIA-AE and Interactive Digital TV as integrated platforms to support the distance education in the Amazon state. The project is work in progress, and we plan to submit it to the pilot classroom group for tests in mid-2010.
Energy Industry: Effectiveness from Innovations

Putting the energy industry on the way of innovations is a task of utmost importance, whose success will shape up future development and competitiveness of emerging economies to a great extent. Research of the main trends of innovative development of distributed generation demonstrated that they are characterized by high spending both on installation of innovative power equipment and on its creation. Our research of financing in the Russian distributed energy and power engineering demonstrated that the bulk of capital investment is done from companies’ own funds, which points to the unaffordability of other funding instruments, credit included. Consequently, the process of creating and using innovations in distributed energy is accompanied by significant investment risks. This scientific research offers an approach to innovations in distributed energy based on coordination of economic interests of innovation process subjects with the aim of optimizing the task of looking for a threshold price through defining and comparing the effectiveness of a novelty for its creators, consumers and the state with the help of an internal rate of return. The use of a business approach to the introduction of innovations in the distributed energy will coordinate the interests of the producer of innovative equipment and the energy company. Such an approach will ensure co-financing of innovation research and development of all subjects of the relations.
The propagation constant of coaxial offset shorts with rough surfaces

Offset short calibration schemes for vector network analyzers require the exact knowledge of the propagation constant of the offsetting lines. The propagation constant is difficult to compute from first principles and thus a method to indirectly determine the propagation constant is presented. At 50 GHz, the method achieves improvements of accuracy of at least 0.013 in linear S-parameters for a 2.4mm offset short with length 13 mm.
Upper limb nerve injuries in developmental age

Our series includes 105 children with peripheral nerve injuries of the upper limb due to trauma. The aim of this study is to validate our therapeutic approach to peripheral nerve injuries of the upper limb in children and to identify the suitable waiting time before surgical exploration. Case series examination included evaluation of (1) type of lesion; (2) topographical site of nerve injury; (3) motor and sensory outcome; (4) recovery time; (5) results after surgery. Open injuries (Sunderland V) received immediate treatment with direct suturing or nerve grafts or biological tubules in case of loss of nerve substance. After closed nerve injury, a waiting period of variable duration should precede surgery. Most of the cases had peripheral nerve injuries associated to fracture and cutting lesions followed by injuries due to other causes. Open or closed injuries of the median and radial nerves had a generally favorable prognosis, whereas ulnar nerve injuries (both isolated and associated) had a poor prognosis. Stable skeletal fixation is essential in fractures at risk of nerve involvement. During nerve exploration, secondary surgery interventions were never associated. In the absence of adequate clinical and instrumental response, the authors suggest to resort to nerve surgery at 6 months from injury to accelerate recovery time. Secondary surgery should be delayed as patient's recovery time can be very long. © 2009 Wiley‐Liss, Inc. Microsurgery, 2009.
Radiologic and clinical outcomes with special reference to tumor involvement pattern after stent placement for malignant bronchial obstructions

Background: Location of tumor within the tracheobronchial tree as well as its severity can affect the clinical outcome of patients who undergo airway stent placement. Purpose: To evaluate radiologic and clinical outcome, including survival data, with special reference to proposed tumor involvement pattern, in patients with malignant bronchial strictures. Material and Methods: A total of 35 patients who underwent stent placement for malignant bronchial strictures were enrolled over a 9-year period. Tumor involvement pattern was divided into three types based on computed tomography (CT) scans and selective bronchography. Type I was defined as tumor involving only the main stem bronchus; type II, tumor involving the bronchus intermedius and/or the lower lobar bronchus without involvement of the lower-lobe segmental bronchus; and type III, tumor involving the lower lobar bronchus with involvement of the lower-lobe segmental bronchus. Tumor stage, lung collapse/infiltration, radiologic improvement, clinical improvement, and survival were compared according to the tumor involvement pattern. Results: Tumor involvement pattern was of type I, II, and III in 14, 13, and eight patients, respectively. When comparisons were made between types I/II and type III to evaluate the influence of lower-lobe segmental bronchial involvement, radiologic and clinical improvement was significantly lower in type III than in types I/II, while advanced stage, lung collapse/infiltration, and median overall survival were not significantly different between types I/II and type III. Conclusion: In patients with malignant bronchial obstructions involving the lower-lobe segmental bronchus, clinicians must be aware of the possibility of less radiologic and clinical improvement following stent placement.
Integration of Software Measurement Supporting Tools: A Mapping Study

During software projects, it is necessary to collect, store and analyze data to support decision making at project and organizational levels. Software measurement is a key practice to process quality improvement and project management. Given the nature of measurement activities, supporting tools are essential. Different tools can be combined to support the measurement process and provide the necessary information for decision making. However, usually these tools are developed by different developers, at different points in time and without concern for integration. As a result, organizations have to deal with integration issues to allow tools communication and properly support the measurement process. This paper presents a study investigating in the literature initiatives involving tools integration to support software measurement. As a result, twelve proposals were analyzed and their characteristics are presented.
Do U.S. Firms Disguise Acquisitions to Avoid Taxes?

We present evidence that tax laws distort acquisition decisions for many of the largest U.S. firms. We find that tax “sophistication”, proxied by the use of Double Irish subsidiary structures, is associated with between a 7.4% and 15.1% increase in domestic acquisitions. These results are concentrated in deals less likely to trigger regulatory scrutiny, and these deals are associated with decreases in offshore earnings using difference-in-difference tests. This is consistent with sophisticated firms using complicated transactions to invest pre-tax offshore profits domestically without repatriation taxes. We control for several sources of endogeneity that potentially affect other foreign tax minimization proxies.
Short-Range Burst Mode Wireless Optical Interconnection System of Moving Object

The burst mode wireless optical interconnection system for moving object is proposed for specific situations to achieve higher transmission performance contrasting with other transmission methods. The design of optical transceivers and the process of system are described in the paper. System presented applies special frame structure and data encoding to ensure data correctness and completeness in high-speed bursting data transmission. In addition, the communication window model of the optical channel is calculated and confirmed with experiment. Experimental results show that: The communicate performance reaches the demand of system, which bit error rate achieves the value of lower than 10^(-7).
(E)-3,3′-(Diazene-1,2-diyl)bis(1-methyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-5-ium) dinitrate dihydrate

The title compound, C12H18N8 2+·2NO3 −·2H2O, was synthesized unexpectedly from 3-amino-1-methyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-5-ium chloride and cerium(IV) ammonium nitrate. The cation has a crystallographically imposed centre of symmetry. In the crystal, the ions and water molecules are linked via O—H⋯N, N—H⋯O and O—H⋯O hydrogen bonds into a three-dimensional network.
The tyrosine degradation gene hppD is transcriptionally activated by HpdA and repressed by HpdR in Streptomyces coelicolor, while hpdA is negatively autoregulated and repressed by HpdR

Streptomyces coelicolor produces a brown pigment on nutrient‐limited agar medium (Tyr‐PM) using l‐tyrosine as the sole nitrogen and carbon source. The pigment production is associated with the second step of l‐tyrosine catabolism catalysed by 4‐hydroxyphenylpyruvate dioxygenase (HppD), which converts 4‐hydroxyphenylpyruvate (4HPP) to 2, 5‐dihydroxyphenylacetate (homogentisate) to provide the carbon and energy substrates for the growth of S. coelicolor on Tyr‐PM. An hppD mutant did not produce brown pigment, and its normal growth was impaired on Tyr‐PM. hpdA and hpdR, located close to hppD, were identified as activator and repressor genes for hppD transcription in the presence of tyrosine. hpdA, divergently transcribed from hppD, is negatively autoregulated in the absence of tyrosine, whereas it is repressed by both its own protein and HpdR in the presence of tyrosine. Electrophoretic mobility shift assays and footprinting experiments showed that HpdA and HpdR each bind to an overlapping region spanning the promoters of both hppD and hpdA, and that 4HPP, instead of tyrosine, is the specific ligand modulating the binding patterns and footprints of HpdA and HpdR on the hppD–hpdA promoter region. These results suggested that the transcription of hppD is subject to coarse and fine control by a complex regulatory system.