Miracle-dz/UniFAR-FTUs huggingface dataset:
Neural correlates of moral judgment in pedophilia

Abstract Pedophilia is a sexual preference that is often associated with child sex offending (CSO). Sexual urges towards prepubescent children and specifically acting upon those urges are universally regarded as immoral. However, up until now, it is completely unknown whether moral processing of sexual offenses is altered in pedophiles. A total of 31 pedophilic men and 19 healthy controls were assessed by using functional magnetic resonance imaging (fMRI) in combination with a moral judgment paradigm consisting of 36 scenarios describing different types of offenses. Scenarios depicting sexual offenses against children compared to those depicting adults were associated with higher pattern of activation in the left temporo-parietal-junction (TPJ) and left posterior insular cortex, the posterior cingulate gyrus as well as the precuneus in controls relative to pedophiles, and vice versa. Moreover, brain activation in these areas were positively associated with ratings of moral reprehensibility and negatively associated with decision durations, but only in controls. Brain activation, found in key areas related to the broad network of moral judgment, theory of mind and (socio-)moral disgust - point to different moral processing of sexual offenses in pedophilia in general. The lack of associations between brain activation and behavioral responses in pedophiles further suggest a biased response pattern or dissected implicit valuation processes.
Low cost angular displacement sensors for biomechanical applications - a review

In the general scientific quest for increased quality of life a natural ambition is to know more about human body kinematics. Varied knowledge can be extracted from sensors placed on human body and through associated biomechanical parameter evaluation the causal connection between different biomechanical parameters and medical conditions can be inferred. From a biomechanical point of view, one of the most important parameters within the human body is the amplitude of angular movements of joints. Although many angular sensors are used in industry, particular characteristics such as small size, flexibility and appropriate attachment methods must be taken into consideration when estimating the amplitude of movement of human joints. This paper reviews the existing low cost easy to manipulate angular sensors listed in the scientific literature, which currently are or could be used in rehabilitation engineering, physiotherapy or biomechanical evaluations in sport. The review is carried out in terms of a classification based on the sensors’ working principles and includes resistive, capacitive, magnetic and piezoresistive sensors.
Importance of apoptotic mechanisms in inflammatory infiltrate of oral lichen planus lesions.

BACKGROUND Oral lichen planus (OLP) is an autoimmune disease produced by T lymphocyte attack on basal epithelial cells. OLP can undergo malignant transformation that may be linked to an increased proliferative activity and decreased apoptosis rate of the epithelial cells, phenomena that may be influenced by the inflammatory infiltrate. The objectives of this study were to assess the quantitative importance of apoptosis in the inflammatory infiltrate of OLP and to discuss its influence on the persistence of this infiltrate and on the malignant transformation of this disease. MATERIALS AND METHODS In 32 patients with OLP and 20 controls, apoptosis was studied by TUNEL assay and caspase-3 determination, while cell cycle arrest and senescence were studied by measurement of p21 expression. RESULTS There was a low frequency of lymphocytic apoptosis according to both TUNEL (34.5% of cases negative, 65.5% with mild expression) and caspase-3 expression (42.9% of cases negative, 50% with mild expression) findings. P21 expression was also negative (9.7% of cases) or mild (80.6% of cases) in most cases. CONCLUSION The absence or low rate of apoptosis observed in inflammatory cells in OLP appears to contribute to the persistence of the inflammatory infiltrate, potentiating the onset of molecular disorders in epithelial cells and favouring cancer development.
IEEE 802.16/WiMAX-based broadband wireless access and its application for telemedicine/e-health services

In this article we investigate the application of IEEE 802.16-based broadband wireless access (BWA) technology to telemedicine services and the related protocol engineering issues. An overview of the different evolutions of the IEEE 802.16 standard is presented and some open research issues are identified. A survey on radio resource management, traffic scheduling, and admission control mechanisms proposed for IEEE 802.16/WiMAX systems is also provided. A qualitative comparison between third-generation wireless systems and the IEEE 802.16/WiMAX technology is given. A survey on telemedicine services using traditional wireless systems is presented. The advantages of using IEEE 802.16/WiMAX technology over traditional wireless systems, as well as the related design issues and approaches are discussed. To this end, we present a bandwidth allocation and admission control algorithm for IEEE 802.16-based BWA designed specifically for wireless telemedicine/e-health services. This algorithm aims at maximizing the utilization of the radio resources while considering the quality of service requirements for telemedicine traffic. Some performance evaluation results for this scheme are obtained by simulations
Correct-by-design output feedback of LTI systems

Current state-of-the-art correct-by-design controllers are designed for full-state measurable systems. This work extends the applicability of correct-by-design controllers to partially observable linear, time-invariant (LTI) models. Towards the certification of the synthesised controllers, approximate simulation relations are leveraged to attain a quantification for the accuracy of introduced approximations. Additionally, the robustness of the approach allows the extension to models with the presence of probabilistic disturbances on state transitions and on output measurements. In a case study from smart buildings we evaluate the new output-based correct-by-design controller on a physical system with limited sensor information.
Subepidermal blistering disease in a 5-month-old Alaskan Malamute dog with concurrent megaesophagus

Subepidermal blistering disease in a 5-month-old Alaskan Malamute dog with concurrent megaesophagus Min-Hee Kang, Ju-Hun Seung, Jong-Hwan Lee and Hee-Myung Park* BK21 Basic & Diagnostic Veterinary Specialist Program for Animal Diseases, Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, South Korea; Department of Veterinary Anatomy, College of Veterinary Medicine, Konkuk University, Seoul, South Korea
An inverse tone mapping operation with two integer data for HDR images

An inverse tone mapping operation (ITMO) for HDR images with low memory and low computational cost is proposed in this paper. An ITMO generates a high dynamic range (HDR) image from a low dynamic range (LDR) image. It is performed by floating-point operation because HDR images are represented by floating-point data in general. As a result, conventional ITMOs require high computational cost. There are many research works to perform the TMOs with low computational cost. However, most of them are not for inverse TMO, but for forward TMO which converts an HDR image into an LDR image. In order to reduce calculation cost, treat floating-point data as two integer values corresponding to exponent part and mantissa part, and performs ITMO for these integer values separately. In addition, all processes in the method can be performed with fixed-point operation. The experimental results show the proposed method using fixed-point operation is 6.86 times faster compared to the conventional method using floating-point operation.
Matrix support and integral care networks in mental health

Objetivo: Apresentar os conceitos, percepcoes e vivencias trazidas pelos profissionais de Saude Mental sobre seus cotidianos nos servicos. Metodos: Trata-se de uma pesquisa de abordagem qualitativa e Analise Institucional sobre Apoio Matricial e Redes de Cuidado Integral em Saude Mental realizada com tres servicos no municipio de Uruguaiana, os dados foram agrupados em categorias e a analise procedeu pela interpretacao e reflexao do conteudo emergido. Resultados: Os resultados apontam para o desvelamento de novos olhares sobre o assunto na perspectiva dos profissionais em saude, visando o debate, a critica e as construcoes coletivas de conceitos e resolucoes de situacoes problemas que mostraram as vivencias e as realidades destas equipes. Conclusao: Por fim, busca-se contribuir com a ampliacao do debate a cerca da tematica, considerando sua necessidade de viabilizacao nas praticas nos servicos.
Enablingy the DC solutions characterization using a fuzzy approach

This paper presents a method for characterizing the DC operating points of analog circuits. We construct fuzzy DC equations that model circuit parameter variations and apply a global optimization algorithm to estimate the location of DC points. We applied our method to analyze the stability of a ring oscillator and the influence of the input voltage offset on the DC characteristic of a differential pair. Our results prove the effectiveness of our method in describing circuits DC performance parameters and predicting possibilities of undesired circuit operations.
Introducing an experimental cognitive robotics curriculum at historically black colleges and universities

A successful collaboration between Spelman College and Carnegie Mellon University led to an NSF-funded Broadening Participation in Computing project to set up robotics education laboratories and introduce undergraduate instruction in cognitive robotics at three other Historically Black Colleges and Universities (HBCUs). We give a brief overview of cognitive robotics and the Tekkotsu software architecture, and describe our experiences teaching computer science students with no previous robotics exposure to program sophisticated mobile robots.
IMPROVED SPAMBASE DATASET PREDICTION USING SVM RBF KERNEL WITH ADAPTIVE BOOST

Spam is no more garbage but risk as it includes virus attachments and spyware agents which make the recipients’ system ruined, therefore, there is an emerging need for spam detection. Many spam detection techniques based on machine learning algorithms have been proposed. As the amount of spam has been increased tremendously using bulk mailing tools, spam detection techniques should deal with it. In this paper we have proposed Hybrid classifier Adaptive boost with support vector machine RBF kernel on Spambase dataset. We have also extracted the features first by Principal component analysis. General Terms: Email Spam classification.
Sorafenib controls the epithelial-mesenchymal transition of ovarian cancer cells via EGF and the CD44-HA signaling pathway in a cell type-dependent manner

Cluster of differentiation (CD) 44 and epidermal growth factor (EGF) are closely involved in cellular migration and have been used as stem cell markers. Although the hyaluronan (HA)-binding CD44 is responsible for enhanced cellular motility, the mechanism underlying its actions in various cell types and clinical conditions have yet to be elucidated. In the present study, the multikinase inhibitor sorafenib was used to investigate the diverse effects of EGF stimulation on epithelial-mesenchymal transition (EMT) in ovarian cancer cells using immunoblotting and reverse transcription-polymerase chain reaction. In addition, the association between EGF and CD44/HA signaling pathways in the control of mesenchymal phenotype was determined by gene silencing with small interfering RNA transfection. EGF stimulation of ovarian cancer cells increased cellular migration, mesenchymal transition, CD44 expression and the activation of matrix metalloproteinase (MMP)-2 and MMP-9. Sorafenib effectively suppressed the loss of epithelial characteristics in EGF-treated SK-OV-3 ovarian cancer cells, via targeting the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway. Although treatment of Caov-3 ovarian cancer cells with sorafenib blocked the expression of mesenchymal phenotypes following EGF stimulation, EGF-activated Caov-3 cells exhibited reduced MAPK/ERK signaling. Furthermore, EGF-activated Caov-3 cells increased the expression of hyaluronan synthase 2 and HA-CD44 ligation in EGF-exposed Caov-3 cells, which resulted in the activation of the Ras/Raf/MEK signaling pathway, amplification of migratory activity and the expression of mesenchymal markers, including N-cadherin and vimentin. Furthermore, silencing EGFR in SK-OV-3 cells and CD44 in Caov-3 cells suppressed their migratory activity, through inhibition of the MAPK/ERK pathway. The present results suggested that EGF-mediated signaling may regulate metastasis and invasion of ovarian cancer cells, in a cancer cell type-dependent manner.
Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α

Rationale: Hepatic stellate cells (HSCs) are liver-specific pericytes regulating vascular remodeling during hepatic fibrosis. Here, we investigated how ligustrazine affects HSC pericyte functions. Methods: Rat HSC-T6 and human HSC-LX2 cells were cultured, and multiple molecular experiments including real-time PCR, Western blot, flow cytometry, immunofluorescence, electrophoretic mobility shift assay and co-immunoprecipitation were used to elucidate the underlying mechanisms. Molecular simulation and site-directed mutagenesis were performed to uncover the target molecule of ligustrazine. Rats were intoxicated with CCl4 for evaluating ligustrazine's effects in vivo. Results: Ligustrazine inhibited angiogenic cytokine production, migration, adhesion and contraction in HSCs, and activated PPARγ. Selective PPARγ inhibitor GW9662 potently abrogated ligustrazine suppression of HSC pericyte functions. Additionally, HIF-1α inhibitor PX-478 repressed HSC pericyte functions, and ligustrazine inhibited the transcription of HIF-1α, which was diminished by GW9662. Moreover, ligustrazine downregulation of HIF-1α was rescued by knockdown of SMRT, and ligustrazine increased PPARγ physical interaction with SMRT, which was abolished by GW9662. These findings collectively indicated that activation of PPARγ by ligustrazine led to transrepression of HIF-1α via a SMRT-dependent mechanism. Furthermore, molecular docking evidence revealed that ligustrazine bound to PPARγ in a unique double-molecule manner via hydrogen bonding with the residues Ser289 and Ser342. Site-directed mutation of Ser289 and/or Ser342 resulted in the loss of ligustrazine transrepression of HIF-1α in HSCs, indicating that interactions with both the residues were indispensable for ligustrazine effects. Finally, ligustrazine improved hepatic injury, angiogenesis and vascular remodeling in CCl4-induced liver fibrosis in rats. Conclusions: We discovered a novel ligand activation pattern for PPARγ transrepression of the target gene with therapeutic implications in HSC pericyte biology and liver fibrosis.
Neural basis of fear conditioning induced by video clip: Positron emission tomography study

Abstract In patients with post‐traumatic stress disorder (PTSD), re‐experiencing the trauma is often induced by external cues in the environment. The cues, which were emotionally neutral for the patients before the traumatic event, become fearful ones after the event. This phenomenon is considered to be associated with fear conditioning. The paradigm was set up so that the emotionality changes in the patients with PTSD would be reproduced, and the regional cerebral blood flow (rCBF) measured with positron emission tomography (PET) was compared during exposure to the same stimuli before and after acquisition of fear conditioning. Ten healthy male subjects were asked to look at some emotionally neutral photos, then to watch a video with fearful content that also contained images similar to that presented in the photos, and afterwards to look at the photos again. Five of the 10 subjects felt that the object in the photos was more fearful after watching the video than before, and they were considered to have acquired fear conditioning. In those five subjects, the rCBF in the right amygdala and the left posterior cingulate gyrus after acquisition of fear conditioning significantly increased relative to the rCBF before conditioning. Thus, these regions seem to have a critical role in fear conditioning.
Ginzburg–Landau Theory of Phase Transitions in Compactified Spaces

are considering a space which has a topology of the type ΓD = ( S1 d × RD−d, with d (≤ D) being the number of compactified dimensions, each with the topology of a circle. This is the type of topology that emerges, for instance, in quantum field theory at finite temperature: the Matsubara formalism imposes that the time direction is compactified in a circle with length β = 1/T , where T is the temperature; its topology is then Γ4 = S 1 × R3 in the notation introduced above. Another important example involves spacetimes of dimensions D larger than four, with the “extra” or “hidden” dimensions being compactified and assumed to be very small, as in Kaluza–Klein and string theories. In any case, the topology ΓD mentioned above corresponds to a generalized Matsubara formalism, in which imaginary-time and spatial coordinates may be simultaneously compactified.
Modified adaptive controller for linear plants with improved parametric robustness and transient performance

The paper proposes a simple modification of adaptive controller of Krstic et al. (1994a) leading to a further improvement of its parametric robustness and transient performance. This improvement is achieved with the use of a new form of the plant parametrization. The theoretical results are illustrated by a simulation comparison.
Functional Analysis of Cotton Leaf Curl Kokhran Virus/Cotton Leaf Curl Multan Betasatellite RNA Silencing Suppressors

In South Asia, Cotton leaf curl disease (CLCuD) is caused by a complex of phylogenetically-related begomovirus species and a specific betasatellite, Cotton leaf curl Multan betasatellite (CLCuMuB). The post-transcriptional gene silencing (PTGS) suppression activities of the transcriptional activator protein (TrAP), C4, V2 and βC1 proteins encoded by Cotton leaf curl Kokhran virus (CLCuKoV)/CLCuMuB were assessed in Nicotiana benthamiana. A variable degree of local silencing suppression was observed for each viral protein tested, with V2 protein exhibiting the strongest suppression activity and only the C4 protein preventing the spread of systemic silencing. The CLCuKoV-encoded TrAP, C4, V2 and CLCuMuB-encoded βC1 proteins were expressed in Escherichia coli and purified. TrAP was shown to bind various small and long nucleic acids including single-stranded (ss) and double-stranded (ds) RNA and DNA molecules. C4, V2, and βC1 bound ssDNA and dsDNA with varying affinities. Transgenic expression of C4 under the constitutive 35S Cauliflower mosaic virus promoter and βC1 under a dexamethasone inducible promoter induced severe developmental abnormalities in N. benthamiana. The results indicate that homologous proteins from even quite closely related begomoviruses may differ in their suppressor activity and mechanism of action. The significance of these findings is discussed.
A New Second-Order All-Pass Filter in 130-nm CMOS

This brief presents a novel wide-bandwidth second-order voltage-mode all-pass filter derived from a canonical single transistor bandpass filter. The core of the circuit consists of only one transistor, two resistors, and two energy storage elements. The operation of the proposed filter is validated experimentally. A filter implemented in an IBM 0.13-μm CMOS was measured to have a 55-ps group delay across a 6-GHz bandwidth while consuming 18.5 mW from a 1.5-V supply. This work experimentally demonstrates a CMOS all-pass filter that operates at multigigahertz frequencies and achieves the highest delay-bandwidth product compared to previously published CMOS all-pass filters known to the authors.
Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages*

Modification of low density lipoprotein (LDL) can result in the avid uptake of these lipoproteins via a family of macrophage transmembrane proteins referred to as scavenger receptors (SRs). The genetic inactivation of either of two SR family members, SR-A or CD36, has been shown previously to reduce oxidized LDL uptakein vitro and atherosclerotic lesions in mice. Several other SRs are reported to bind modified LDL, but their contribution to macrophage lipid accumulation is uncertain. We generated mice lacking both SR-A and CD36 to determine their combined impact on macrophage lipid uptake and to assess the contribution of other SRs to this process. We show that SR-A and CD36 account for 75–90% of degradation of LDL modified by acetylation or oxidation. Cholesteryl ester derived from modified lipoproteins fails to accumulate in macrophages taken from the double null mice, as assessed by histochemistry and gas chromatography-mass spectrometry. These results demonstrate that SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence.
Prognostic Factors and Radiographic Outcomes of Nontuberculous Mycobacterial Lung Disease in Rheumatoid Arthritis

Objective. The aims of our study were to retrospectively review patients with rheumatoid arthritis (RA) with nontuberculous mycobacterial (NTM) lung disease, to assess the prognostic factors, and to analyze the time to disease deterioration according to the antirheumatic drugs received during the NTM lung disease followup period. Methods. We retrospectively analyzed medical records of 98 HIV-negative RA patients with NTM lung disease treated at our institution, and investigated potential risk factors of mortality with Cox regression analysis. Time to radiologic deterioration was evaluated if antirheumatic drugs were not changed during observational periods and computed tomography was performed once each year. Results. Mean patient age was 67.6 years, and median followup period was 4.4 years. NTM species included Mycobacterium avium complex (83.7%), M. kansasii (6.1%), M. gordonae (6.1%), and others (4.1%). Radiographic features included nodular/bronchiectatic (NB) disease (57.1%), fibrocavitary (FC) disease (14.3%), FC+NB disease (16.3%), and other types (12.2%). Initial management included observation in 74 (75.5%) patients. Negative prognostic factors of mortality were C-reactive protein (CRP) ≥ 1.0 mg/dl and radiographic features of FC, FC+NB, or other disease types. Median time to radiologic deterioration was 3.6 years. Erythrocyte sedimentation rate (ESR) > 50 mm/h was a negative prognostic factor of radiologic deterioration. Conclusion. The most frequent NTM species was M. avium complex. CRP and radiographic features were prognostic factors for all-cause mortality, and ESR was a prognostic factor of radiologic deterioration. Further studies are warranted focusing on time to disease deterioration according to antirheumatic drug received during NTM followup.
The Research and Application of Random Sampling in Digital Storage Oscilloscope

In order to implement sampling wide band signal, the random sampling method is always taken in designing of the digital storage oscilloscope (DSO). The exact definition of equivalence sampling and random sampling is given in this article. It discusses the realization methods of random sampling and gives a new random sampling method with self calibration capability. With this method, the errors will be reduced as well as the sampling rate is improved.sigma