Miracle-dz/UniFAR-FTUs huggingface dataset:
A modified Phase I trial of radiation dose escalation in 3D conformal radiation therapy with concurrent vinorelbine and carboplatin chemotherapy for non-small-cell lung cancer

The Radiation Therapy Oncology Group reported a maximum tolerated dose of 74 Gy for patients with non-small cell lung cancer (NSCLC); however, it was unclear whether this dose could be safely administered to Asian patients due to differences in their physique compared to Western patients. We therefore conducted a modified Phase I trial to determine whether 70 Gy could be safely delivered to Chinese patients with NSCLC undergoing 3D-conformal radiation therapy (3D-CRT) with concurrent chemotherapy. Previously untreated NSCLC patients received 3D-CRT (2 Gy/day, 5 fractions per week). Three dose levels were examined: 62, 66 and 70 Gy. Two cycles of concurrent chemotherapy (vinorelbine and carboplatin) were started on the first day of radiation therapy. Dose-limiting toxicity (DLT) was defined as severe or life-threatening side effects that altered the continued implementation of chemoradiotherapy. Among the 19 patients recruited in this study, most of the haematologic and non-haematologic toxicities were mild to moderate and clinically manageable. Only one patient, in the 70 Gy cohort, experienced a DLT of Grade 3 radiation-induced pneumonia. The overall response rate was 77.8% (14/18). The median progression-free survival (PFS) was 12 months, and the 1-year PFS was 37.6%. Our results support both the feasibility of incorporating 3D-CRT with concurrent vinorelbine and carboplatin and a dose escalation to 70 Gy for Chinese patients with NSCLC, based on the acceptable toxicity and encouraging overall response and survival rates. A further evaluation of this regimen in a prospective Phase II trial is ongoing.
Weak modules and logarithmic intertwining operators for vertex operator algebras

We consider a class of weak modules for vertex operator algebras that we call logarithmic modules. We also construct nontrivial examples of intertwining operators between certain logarithmic modules for the Virasoro vertex operator algebra. At the end we speculate about some possible logarithmic intertwiners at the level $c=0$.
Factors persuade individuals’ behavioral intention to opt for Islamic bank services

Purpose The sustainable development of Islamic banking services has motivated a significant number of depositors to choose Islamic bank services instead of the conventional bank. There are various factors that can persuade the depositors’ choice to choose an Islamic bank. This paper aims to examine the factors that persuade individuals’ behavioral intention to choose Islamic bank services. Design/methodology/approach To achieve this objective, this study uses the theory of planned behavior (TPB) as the underlying theory to measure the factors that persuade the depositors’ behavioral intention to choose Islamic bank services. A total of 300 questionnaires were distributed to the Malaysian Islamic Bank’s depositors in Peninsular Malaysia. The data from the questionnaires were analyzed using structural equation modeling (SEM). Findings The result showed the three variables that predicted behavioral intentions of the depositors, namely, attitude (ATT), subjective norms (SN) and perceived behavioral control (PBC), were found to be significant in persuading depositors’ behavioral intention to choose Islamic bank services. Furthermore, the findings of the study also confirmed the relevance of using TPB to measure the depositors’ behavioral intention. The results could advance knowledge in the area of Islamic finance and also have positive implications for practitioners. Originality/value The study offers an insight into the present environment involving Islamic banking services which was established in Malaysia 30 years ago. In the context of the current study, the present environment refers to the depositors’ intention to opt for the service and the factors that influence the depositors to choose Islamic banking services apart from the religious factor which has been well acknowledged by a significant number of previous studies.
Possibilities of Reflectance Spectroscopy to Predict Soil Arsenic

With the rapid development of economy in China, more and more toxic elements, such as As, are transferred to soils and the soil contamination is becoming more and more serious. To obtain the information of soil properties through conventional laboratory methods is time-consuming and expensive. Therefore, it is important to develop new methods of soil analysis which is fast, convenient and nondestructive. This paper used the partial least squares (PLS) regression to investigate the possibilities of reflectance spectroscopy in the VNIR ranges to predict the content of arsenic in the soil samples. The good results show that soil spectroscopy in VNIR is a promising method for prediction of As concentration in soil.
Tree Kernel-Based Semantic Relation Extraction Using Unified Dynamic Relation Tree

This paper proposes a unified dynamic relation tree (DRT) span for tree kernel-based semantic relation extraction between entity names. The basic idea is to apply a variety of linguistics-driven rules to dynamically prune out noisy information from a syntactic parse tree and include necessary contextual information. In addition, different kinds of entity-related semantic information are unified into the syntactic parse tree. Evaluation on the ACE RDC 2004 corpus shows that the unified DRT span outperforms other widely-used tree spans, and our system achieves comparable performance with the state-of-the-art kernel-based ones. This indicates that our method can not only well model the structured syntactic information but also effectively capture entity-related semantic information.
Thermo-mechanical transient analysis of concrete structure around the nuclear reactor

This paper deals with transient thermal — stress analysis of concrete structure around the nuclear reactor loaded by dead load and thermal loads. The FEM simulations were performed for various input materials characteristic of concrete based on experimentally obtained physical-mechanical properties and measuring of temperatures. The proposed calculation model, procedures of numerical simulation have been describing conclusions of analysis. The numerical simulation has been performed by means of the finite element method (FEM) using a commercially available ANSYS code. c © 2008 University of West Bohemia in Pilsen. All rights reserved.
Bioingenium at ImageClefmed 2010: A Latent Semantic Approach

This paper describes the participation of the Bioingenium Research Group in the ad hoc Medical Image Retrieval task for the 2010 ImageCLEF forum. The work aimed to explore semantic relationships in textual information and transfer into visual information by building a unied image searching index. The proposed strategy is based on the use of Non-Negative Matrix Factorization to decompose matrix data and build latent semantic spaces.
Effect of Arsenic Exposure during Pregnancy on Infant Development at 7 Months in Rural Matlab, Bangladesh

Background Exposure to arsenic-contaminated drinking water during pregnancy is associated with low birth weight and fetal loss, and there is concern that the infants’ development may be affected. Objective We assessed the effects of in utero arsenic exposure during pregnancy on infants’ problem-solving ability and motor development. Methods We conducted a large population-based study of nutritional supplementation with 4,436 pregnant women in Matlab, Bangladesh, an area of high-arsenic–contaminated tube wells. We measured arsenic concentration in spot urine specimens at 8 and 30 weeks of pregnancy. We assessed a subsample of 1,799 infants, born to these mothers, at 7 months of age on two problem-solving tests (PSTs), the motor scale of the Bayley Scales of Infant Development–II, and behavior ratings. Result Arsenic concentrations in maternal urine were high, with a median (interquartile range) of 81 μg/L (37–207 μg/L) at 8 weeks of gestation and of 84 μg/L (42–230 μg/L) at 30 weeks. Arsenic exposure was related to many poor socioeconomic conditions that also correlated with child development measures. Multiple regressions of children’s motor and PST scores and behavior ratings, controlling for socioeconomic background variables, age, and sex, showed no significant effect of urinary arsenic concentration on any developmental outcome. Conclusion We detected no significant effect of arsenic exposure during pregnancy on infant development. However, it is possible that other effects are as yet unmeasured or that effects will become apparent at a later age.
The truth behind the myth of the folk theorem

We study the problem of computing an ε-Nash equilibrium in repeated games. Earlier work by Borgs et al. [2010] suggests that this problem is intractable. We show that if we make a slight change to their model---modeling the players as polynomial-time Turing machines that maintain state (rather than stateless polynomial-time Turing machines)---and make some standard cryptographic hardness assumptions (the existence of public key encryption), the problem can actually be solved in polynomial time.
Renoprotective Effect of the Combination of Renin-angiotensin System Inhibitor and Calcium Channel Blocker in Patients with Hypertension and Chronic Kidney Disease

Background: Renin-angiotensin system inhibitor and calcium channel blocker (CCB) are widely used in controlling blood pressure (BP) in patients with chronic kidney disease (CKD). We carried out a meta-analysis to compare the renoprotective effect of the combination of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) and CCB (i.e., ACEI/ARB + CCB) with ACEI/ARB monotherapy in patients with hypertension and CKD. Methods: Publications were identified from PubMed, Embase, Medline, and Cochrane databases. Only randomized controlled trials (RCTs) of BP lowering treatment for patients with hypertension and CKD were considered. The outcomes of end-stage renal disease (ESRD), cardiovascular events, BP, urinary protein measures, estimated glomerular filtration rate (GFR), and adverse events were extracted. Results: Based on seven RCTs with 628 patients, ACEI/ARB + CCB did not show additional benefit for the incidence of ESRD (risk ratio [RR] = 0.84; 95% confidence interval [CI]: 0.52–1.33) and cardiovascular events (RR = 0.58; 95% CI: 0.21–1.63) significantly, compared with ACEI/ARB monotherapy. There were no significant differences in change from baseline to the end points in diastolic BP (weighted mean difference [WMD] = −1.28 mmHg; 95% CI: −3.18 to −0.62), proteinuria (standard mean difference = −0.55; 95% CI: −1.41 to −0.30), GFR (WMD = −0.32 ml/min; 95% CI: −1.53 to −0.89), and occurrence of adverse events (RR = 1.05; 95% CI: 0.72–1.53). However, ACEI/ARB + CCB showed a greater reduction in systolic BP (WMD = −4.46 mmHg; 95% CI: −6.95 to −1.97), compared with ACEI/ARB monotherapy. Conclusion: ACEI/ARB + CCB had no additional renoprotective benefit beyond than what could be achieved with ACEI/ARB monotherapy.
Injury in the Hearts of Transgenic Mice With a Tamoxifen-Regulated Form of ATF 6 Endoplasmic Reticulum Stress Gene Induction and Protection From Ischemia / Reperfusion

Ischemia/reperfusion (I/R) affects the integrity of the endoplasmic reticulum (ER), the site of synthesis and folding of numerous proteins. Therefore, I/R may activate the unfolded protein response (UPR), resulting in the induction of a collection of ER stress proteins, many of which are protective and function to resolve the ER stress. In this study, we showed that when mouse hearts were subjected to ex vivo I/R, the levels of 2 ER stress-inducible markers of the UPR, the ER-targeted cytoprotective chaperones glucose-regulated proteins 78 and 94 (GRP78 and GRP94), were increased, consistent with I/R-mediated UPR activation in the heart. The UPR-mediated activation of ATF6 (Activation of Transcription Factor 6) induces cytoprotective ER stress proteins, including GRP78 and GRP94. To examine whether ATF6 protects the myocardium from I/R injury in the heart, we generated transgenic (TG) mice featuring cardiac-restricted expression of a novel tamoxifen-activated form of ATF6, ATF6-MER. When NTG and ATF6-MER TG mice were treated with or without tamoxifen for 5 days, only the hearts from the tamoxifen-treated TG mice exhibited increased levels of many ER stress–inducible mRNAs and proteins; for example, GRP78 and GRP94 transcript levels were increased by 8and 15-fold, respectively. The tamoxifen-treated TG mouse hearts also exhibited better functional recovery from ex vivo I/R, as well as significantly reduced necrosis and apoptosis. These results suggest that the UPR is activated in the heart during I/R and that, as a result, the ATF6 branch of the UPR may induce expression of proteins that can function to reduce I/R injury. (Circ Res. 2006;98:1186-1193.)
The Conserved Candida albicans CA3427 Gene Product Defines a New Family of Proteins Exhibiting the Generic Periplasmic Binding Protein Structural Fold

Nosocomial diseases due to Candida albicans infections are in constant rise in hospitals, where they cause serious complications to already fragile intensive care patients. Antifungal drug resistance is fast becoming a serious issue due to the emergence of strains resistant to currently available antifungal agents. Thus the urgency to identify new potential protein targets, the function and structure of which may guide the development of new antifungal drugs. In this context, we initiated a comparative genomics study in search of promising protein coding genes among the most conserved ones in reference fungal genomes. The CA3427 gene was selected on the basis of its presence among pathogenic fungi contrasting with its absence in the non pathogenic Saccharomyces cerevisiae. We report the crystal 3D-structure of the Candida albicans CA3427 protein at 2.1 Å resolution. The combined analysis of its sequence and structure reveals a structural fold originally associated with periplasmic binding proteins. The CA3427 structure highlights a binding site located between the two protein domains, corresponding to a sequence segment conserved among fungi. Two crystal forms of CA3427 were found, suggesting that the presence or absence of a ligand at the proposed binding site might trigger a “Venus flytrap” motion, coupled to the previously described activity of bacterial periplasmic binding proteins. The conserved binding site defines a new subfamily of periplasmic binding proteins also found in many bacteria of the bacteroidetes division, in a choanoflagellate (a free-living unicellular and colonial flagellate eukaryote) and in a placozoan (the closest multicellular relative of animals). A phylogenetic analysis suggests that this gene family originated in bacteria before its horizontal transfer to an ancestral eukaryote prior to the radiation of fungi. It was then lost by the Saccharomycetales which include Saccharomyces cerevisiae.
Long-term results of autologous cultivated oral mucosal epithelial transplantation in the scar phase of severe ocular surface disorders

Purpose To investigate the long-term outcome of autologous cultivated oral mucosal epithelial transplantation (COMET) for the treatment of the scar phase of severe ocular surface disorders. Participants This study involved 19 eyes of 17 patients who received autologous COMET for total limbal stem-cell deficiency. Methods Autologous cultivated oral mucosal epithelial sheets were created using amniotic membrane as a substrate. Clinical efficacy was evaluated by best-corrected visual acuity and visual acuity at the postoperative 36th month. The clinical results (clinical conjunctivalisation, corneal opacification, corneal neovascularisation and symblepharon formation) were evaluated and graded on a scale from 0 to 3 according to their severity. Clinical safety was evaluated by the presence of persistent epithelial defects, ocular hypertension and infections. Results Autologous cultivated oral mucosal epithelial sheets were successfully generated for all 17 patients. All patients were followed up for more than 36 months; the mean follow-up period was 55 months and the longest follow-up period was 90 months. During the long-term follow-up period, postoperative conjunctivalisation and symblepharon were significantly inhibited. All eyes manifested various degrees of postoperative corneal neovascularisation, but it gradually abated and its activity was stable at 6 months after surgery. Best-corrected visual acuity was improved in 18 eyes (95%) during the follow-up periods, and visual acuity at the postoperative 36th month was improved in 10 eyes (53%). Conclusions These long-term clinical results strongly support the conclusion that tissue-engineered cultivated oral mucosal epithelial sheets are useful in reconstructing the ocular surface of the scar phase of severe ocular surface disorders.
A Layer Architecture for the Integration of Rules, Inheritance, and Constraints

We informally introduce TaxLog, a close integration of logic programming and terminological reasoning. Terminological systems are handling declarative logic-based descriptions of conceptual knowledge. Most of them restrict their expressiveness and focus on (eecient) reasoning algorithms for certain services. This imposes principal restrictions on the expressivity of such a formalism. To get maximal beneet of terminological reasoning, while being able to overcome these expressiveness deeciencies, the terminological system Taxon has been integrated with logic programming by applying a CLP scheme to its assertional formalism. Because Taxon itself is an amalgamation of an abstract concept language by concrete domains (such as predicates over rational numbers) we have a three-layered system architecture: 1) rules on the basis of a tuned vocabulary which is formulated in 2) a concept language that is grounded by 3) concrete domains. We will discuss this layered architecture as a main prerequisite of several advantages in software/knowledge engineering, thus promoting a new discussion about principles of hybrid systems design (which is necessary when trying to gain practical relevance for declarative programming). 1 Motivation Newer results in knowledge representation (KR) and expert system technology suggest to turn our attention away from the idea of a uniform general-purpose language of declar-ativity towards heterogeneous hybrid systems. These ooer several distinct representation formalisms, each of them especially tailored for natural description (and eecient processing) of certain aspects of the domain knowledge.
English to Tamil statistical machine translation and alignment using HMM

This paper describes English to Tamil statistical machine translation and its alignment using Hidden Markov Model (HMM). Statistical machine translation is a part of natural language processing and is based on probability distribution. Machine translation is a sub-field of computational linguistics that uses computer software to translate text in one natural language to another language. Alignment is one of the major challenges in machine translation . Hidden markov model (HMM) based alignment described in this paper is more accurate, avoids invalid alignments and improves translation quality. HMM uses bigram translation probabilities for keeping word context in the language model which produce close to error-free output that reads fluently in the target language.
Post Facto Registration Tools for Urban Modelling

Urban modelling applications require high-precision geometric models both for graphical rendering and for engineering purposes. While geometric models, photographic images and laser-scanned point clouds are ideally co-registered to national coordinate grids at the time of acquisition, the quantity and diversity of data sources means that registration must often be performed post facto. Moreover, the sheer size of urban point clouds prevents automated conversion and registration of the entire data set at once. We describe an interactive tool that manages the workflow for converting urban-scale point clouds to grid-registered geometric models. Our “user in the loop” approach lets us leverage natural human understanding of the data to bypass issues of scale.
Extending BCCNR flavored geometry to the negative coupling constant region

We extend BCCNR's flavored KW and KS geometries into the negative coupling constant region and try giving physical explanations from the dual gauge theory side. We show that, in the extended region, except the coupling constant being negative, all other fields of the super-gravity theory having good properties which can be described by the dual gauge theory.
Pkc1 Acts Through Zds1 and Gic1 to Suppress Growth and Cell Polarity Defects of a Yeast eIF5A Mutant

eIF5A is a highly conserved putative eukaryotic translation initiation factor that has been implicated in translation initiation, nucleocytoplasmic transport, mRNA decay, and cell proliferation, but with no precise function assigned so far. We have previously shown that high-copy PKC1 suppresses the phenotype of tif51A-1, a temperature-sensitive mutant of eIF5A in S. cerevisiae. Here, in an attempt to further understand how Pkc1 functionally interacts with eIF-5A, it was determined that PKC1 suppression of tif51A-1 is independent of the cell integrity MAP kinase cascade. Furthermore, two new suppressor genes, ZDS1 and GIC1, were identified. We demonstrated that ZDS1 and ZDS2 are necessary for PKC1, but not for GIC1 suppression. Moreover, high-copy GIC1 also suppresses the growth defect of a PKC1 mutant (stt1), suggesting the existence of a Pkc1-Zds1-Gic1 pathway. Consistent with the function of Gic1 in actin organization, the tif51A-1 strain shows an actin polarity defect that is partially recovered by overexpression of Pkc1 and Zds1 as well as Gic1. Additionally, PCL1 and BNI1, important regulators of yeast cell polarity, also suppress tif51A-1 temperature sensitivity. Taken together, these data strongly support the correlated involvement of Pkc1 and eIF5A in establishing actin polarity, which is essential for bud formation and G1/S transition in S. cerevisiae.
IPv6 prefix delegation-based addressing solution for a mobile personal area network

This paper provides a dynamic IPv6 prefix delegation-based addressing solution to enable Internet connectivity when a Personal Area Network (PAN) is moving between sub-networks. A PAN consists of a cluster of mobile devices, which are dynamically connected with each other and move around together. The approach is based on IPv6 stateless address auto-configuration, and Automatic Prefix Delegation Protocol for IPv6. The problems related to addressing, mobility and IPv6 prefix delegation are evaluated with the constructed prototype. The experiences indicate that the solution is quite light and enables session continuity in subnet changes for any mobile node of a PAN. In addition, the solution does not exclude application of Mobile IPv6 (MIPv6), however Mobile IPv6 is not necessarily needed when Session Initiation Protocol (SIP) based mobility is applied By using SIP, route optimization is also achieved and IPv6 encapsulation is avoided with UDP-based sessions. However, the solution is not necessarily very scalable to big mobile networks.