Miracle-dz/UniFAR-FTUs huggingface dataset:
A Dynamic Coherency Identification Method Based on Frequency Deviation Signals

This paper presents a new method to dynamically determine coherent generators and electrical areas of an interconnected power system. The proposed method is based on dynamic frequency deviations of both generator and non-generator buses, with respect to the system nominal frequency. The proposed method 1) largely overcomes the limitations of the existing model-based and measurement-based coherency identification methods, 2) enables dynamic tracking of the coherency time-evolution, and 3) provides noise immunity which is imperative in practical implementation. The method also promises the potential for real-time coherency calculation. The proposed method is applied to the 16-machine/68-bus NPCC system based on time-domain simulation studies in the PSS/E platform and the results are compared with those of the classical slow-coherency (model-based) method and a measurement-based method.
Impact of market orientation on environmental sustainability strategy

Purpose – This study aims to assess the impact of an established market orientation on the implementation of green supply chain practices and environmental performance. Design/methodology/approach – Data collected from 225 manufacturing managers are analyzed using a partial least squares structural equation modeling methodology. Findings – Findings indicate that market orientation both directly and indirectly (through green supply chain management practices) impacts environmental performance. Research limitations/implications – The study focuses on the impact of a market orientation on environmental sustainability within the manufacturing sector, thereby limiting generalization to other sectors. Practical implications – Manufacturing practitioners are provided with information emphasizing the importance of implementing and maintaining a strong market orientation as a precursor to establishing an environmental sustainability strategy. Social implications – The results have important societal implications, .
Fiscal Fan Charts: A Tool for Assessing Member States' (Likely?) Compliance with EU Fiscal Rules

This paper sets out a methodology for constructing fan charts for the government deficit and debt ratios over the medium-term. It relies on information contained in Stability/Convergence Programme Updates, a model of the relevant stochastic process (for example, the real GDP process) or processes, and a parameter estimate of the sensitivity of the primary budget balance to the output gap for the member state under consideration. A model of the dynamic deficit-debt relationship allows the impact of random output growth to work its way through the fiscal arithmetic in a consistent and traceable way to produce fan charts over a five-year forecast horizon. The initial set of fiscal fan charts included here for Ireland use the indicative public finance projections set out in the 2011 Update for Ireland. The range of possible fiscal outcomes in the charts assumes no fiscal policy response to any change in the budgetary position over the period such as could arise from changes in growth rates. This assumption of “no policy change” is a standard one in the construction of fan charts. Governments will, however, generally be in a position to adjust fiscal policy towards meeting a specific fiscal target, such as reaching a deficit position of less than 3 percent of GDP in the medium-term. A second set of fan charts is included which indicates how the probabilistic range of fiscal outcomes could be affected by a tightening of fiscal policy in 2013-2015.
Krüppel-like factors compete for promoters and enhancers to fine-tune transcription

Abstract Krüppel-like factors (KLFs) are a family of 17 transcription factors characterized by a conserved DNA-binding domain of three zinc fingers and a variable N-terminal domain responsible for recruiting cofactors. KLFs have diverse functions in stem cell biology, embryo patterning, and tissue homoeostasis. KLF1 and related family members function as transcriptional activators via recruitment of co-activators such as EP300, whereas KLF3 and related members act as transcriptional repressors via recruitment of C-terminal Binding Proteins. KLF1 directly activates the Klf3 gene via an erythroid-specific promoter. Herein, we show KLF1 and KLF3 bind common as well as unique sites within the erythroid cell genome by ChIP-seq. We show KLF3 can displace KLF1 from key erythroid gene promoters and enhancers in vivo. Using 4sU RNA labelling and RNA-seq, we show this competition results in reciprocal transcriptional outputs for >50 important genes. Furthermore, Klf3−/− mice displayed exaggerated recovery from anemic stress and persistent cell cycling consistent with a role for KLF3 in dampening KLF1-driven proliferation. We suggest this study provides a paradigm for how KLFs work in incoherent feed-forward loops or networks to fine-tune transcription and thereby control diverse biological processes such as cell proliferation.
Structure and growth pattern of the bizarre hemispheric prominence on the rostrum of the fossil beaked whale Globicetus hiberus (Mammalia, Cetacea, Ziphiidae)

The rostrum of most ziphiids (beaked whales) displays bizarre swollen regions, accompanied with extreme hypermineralisation and an alteration of the collagenous mesh of the bone. The functional significance of this specialization remains obscure. With the voluminous and dense hemispheric excrescence protruding from the premaxillae, the recently described fossil ziphiid Globicetus hiberus is the most spectacular case. This study describes the histological structure and interprets the growth pattern of this unique feature. Histologically, the prominence in Globicetus is made up of an atypical fibro‐lamellar complex displaying an irregular laminar organization and extreme compactness (osteosclerosis). Its development is suggested to have resulted from a protraction of periosteal accretion over the premaxillae, long after the end of somatic growth. Complex shifts in the geometry of this tissue are likely to have occurred during its accretion and no indication of Haversian remodeling could be found. X‐ray diffraction and Raman spectroscopy indicate that the bone matrix in the premaxillary prominence of Globicetus closely resembles that of the rostrum of the extant beaked whale Mesoplodon densirostris: apatite crystals are of common size and strongly oriented, but the collagenous meshwork within bone matrix seems to be extremely sparse. These morphological and structural data are discussed in the light of functional interpretations proposed for the highly unusual and diverse ziphiid rostrum. J. Morphol. 277:1292–1308, 2016. © 2016 Wiley Periodicals, Inc.
The effects of government financial support on business innovation in South Korea

This paper briefly explains the evolution of the Korean government's financial support for business innovation and then presents an economic analysis of the effects of the government's research and development (R&D) investment on innovation output at the firm level. The empirical analysis is based on the Korean Innovation Survey 2005 and uses probit regression models and matching estimators. It found that government funding generally has a positive effect on innovation output at the firm level. When it comes to the level of innovativeness, however, it is revealed that government financial support has a positive, but statistically insignificant, effect on achieving high innovativeness. This finding is especially noteworthy considering how hard the government has tried to level up the novelty of its national innovation system, promoting enterprises to being developers and not just adopters in the innovation process. South Korea has successfully caught up with advanced economies by adopting and adapting imported technologies at a rapid rate.
qqmbr and indentml: Extensible Mathematical Publishing for Web and Paper

We present qqmbr, novel publishing system aimed at preparation of high-quality mathematical publications. One source can be converted to a single interactive webpage, multi-page website or PDF (via LaTeX). The markup language behind qqmbr entitled indentml is designed to be both human-readable and machine-readable (easily parsable). It is possible to extend basic qqmbr markup with custom tags that enrich its semantics and build plugins and applications that query qqmbr documents, extract information from them and process it in an arbitrary way without much effort.
Teaching Redistricting: Letting the People Draw the Lines for the People's House

Abstract The 2012 congressional redistricting was the first for which census data and mapmaking software were available to and easily useable by undergraduate students. We discuss our experience teaching the redistricting process to undergraduates and having our students draw constitutionally and statutorily valid congressional districts for Massachusetts. Bringing students into the process is a valuable teaching tool, and it also provides unbiased redistricting scenarios to state legislators and makes the redistricting process more open and transparent. Perhaps contrary to the fears of some legislators, our students placed substantial value on incumbency and the preservation of existing district lines, along with a respect for the traditional redistricting concerns of communities of interest and compactness.
Cytokeratin-18 Is a Useful Serum Biomarker for Early Determination of Response of Breast Carcinomas to Chemotherapy

Purpose: With a widening arsenal of cancer therapies available, it is important to develop therapy-specific predictive markers and methods to rapidly assess treatment efficacy. We here evaluated the use of cytokeratin-18 (CK18) as a serum biomarker for monitoring chemotherapy-induced cell death in breast cancer. Experimental Design: Different molecular forms of CK18 (caspase cleaved and total) were assessed by specific ELISA assays. Drug-induced release of CK18 was examined from breast carcinoma cells and tissue. CK18 protein composition was examined in serum. CK18 levels were determined in serum from 61 breast cancer patients during docetaxel or cyclophosphamide/epirubicin/5-fluorouracil (CEF) therapy. Results: Caspase-cleaved CK18 molecules were released from monolayer cultures and tumor organ cultures to the extracellular compartment. CK18 was present in complexes with other cytokeratins in serum. Such CK18 protein complexes are remarkably stable, leading to favorable performance of CK18 biomarker assays for clinical investigations. Docetaxel induced increased levels of caspase-cleaved CK18 in serum from breast cancer patients, indicating apoptosis. CEF therapy led to increases predominantly in uncleaved CK18, indicating induction of necrotic cell death in many tumors. The increase in total CK18 at 24 h of the first treatment cycle correlated to the clinical response to CEF therapy (P < 0.0001). Conclusions: Induction of necrotic cell death may explain the clinical efficacy of anthracycline-based therapy for breast carcinomas with defective apoptosis pathways. We suggest that CK18 biomarkers are useful for early prediction of the response to CEF therapy in breast cancer and may be useful biomarkers for clinical trials.
The Relevance to Investors of Greenhouse Gas Emission Disclosures

This study documents that investors care about companies’ greenhouse gas (GHG) emission disclosures. Three kinds of evidence support this finding. First, using companies that disclose GHG emissions voluntarily through the Carbon Disclosure Project (CDP), we show that investors act as if they use GHG emission information to assess company value. Second, our evidence finds that investors view estimates of non-disclosed GHG emission amounts as value relevant, suggesting that stock prices reflect GHG information from channels other than CDP disclosure. Third, we conduct an event study and observe a significant stock market response when companies disclose climate change information in an 8-K filing. Our results strengthen for GHG-intensive industries such as utilities, energy, and materials companies, whose valuation effects are more negative. Economically, our results suggest that for every ton of GHG emitted by the median company in our sample at an assumed cost of $20 per ton, the stock market recognizes about 20-50 percent of that amount as an off-balance sheet liability.
The economic effect of the Canadian BSE outbreak on the US economy

Before the discovery of the first Bovine Spongiform Encephalopathy (BSE) cow in May 2003, Canada was the most important exporter of live cattle into the US with a share of 74% of US total live cattle imports. With the outbreak of BSE in Canada, the US ceased imports of Canadian cattle and beef products. This study analyses the short to medium-term effect of the import trade ban for the US economy using a 20 sector, economy wide Computable General Equilibrium (CGE) model. Uncertainty about exogenous elasticity values was addressed using Monte Carlo techniques. Beneficiaries of the trade ban are the cattle industry and related sectors, such as feed production and agricultural service providers. The US economy as a whole, however, is negatively affected with a loss of ∼$-1.7 billion in gross domestic product and –11000 jobs. The model shows how the restriction on Canadian cattle imports generates income losses for both rich and poor households in the US.
Managing the Appropriability of R&D Collaboration

Research and development (R&D) collaboration with various types of external stakeholders is becoming increasingly important for firms pursuing innovation‐related goals. However, collaborating with actors such as customers, suppliers, competitors, and research organisations involves risks related to knowledge leakage and the possible misappropriation of the created value. It is therefore logical to employ mechanisms that safeguard effective knowledge protection and innovation appropriability. In order to shed light on this issue, we conduct an empirical investigation of appropriability mechanisms in R&D collaboration based on a multi‐industry sample from Finland. The results of the study provide novel evidence concerning the relationship between different appropriability mechanisms (intellectual property rights, contracts, labour legislation, human resource management practices, lead time, secrecy, and tacitness) and the firm's propensity to engage in R&D collaboration with various stakeholders.
Cerebrospinal fluid cachectin/tumor necrosis factor-alpha and platelet-activating factor concentrations and severity of bacterial meningitis in children.

In prospective studies, tumor necrosis factor (TNF alpha) was detected in cerebrospinal fluid (CSF) of 33 of 38 children with bacterial meningitis (BM) but in none of 15 with viral meningitis/encephalitis (P less than .001). BM CSF TNF alpha (less than 35 to greater than 25,500 pg/ml) correlated with CSF bacterial density (P less than .01), CSF protein (P less than .001), endotoxin (LPS) in gram-negative disease (P less than .01), and consecutive febrile hospital days (P less than .001); initial CSF TNF alpha greater than 1000 pg/ml was associated with seizures (P less than .05). Only 5 children with BM (13%) had detectable plasma TNF alpha activity on admission. A higher proportion who died had detectable plasma TNF alpha activity compared with survivors (3/4 vs. 2/34, P less than .005). Platelet-activating factor (PAF) in CSF was higher in 19 children with Haemophilus influenzae meningitis than in 17 controls (P less than .01) and correlated with bacterial density (P less than .01), CSF LPS (P less than .01), CSF TNF alpha levels (P less than .01), and the Herson-Todd severity score (P less than .01). Elevated CSF TNF alpha and PAF are often present in children with BM and are associated with seizures and severity of disease. Detectable CSF TNF alpha appears to distinguish BM from viral meningitis.
Suicide in the Greek penal system and the problem of various limitations in relevant studies.

Suicides in prison are not merely self-destructive acts or a "cry for help. " They reflect the inherent need for freedom and the repercussions of imprisonment. SPACE statistics on suicides in prison reveal a rate above 10 per 10,000 in 10 European countries, 4 of which have a rate above 20. Greek data do not appear in all SPACE statistics. This fact has stimulated the present paper. Unpublished data obtained from the Greek Ministry of Justice reveal that Greece belongs to the group of countries with a rate below 10 in 1995 (the year of SPACE statistics). However, the suicide rates fluctuated widely in Greece from a low rate of 3.2 per 10,000 prisoners (convicted, on remand, or hospitalized) in 1982 to the incredibly high rate of nearly 40 in the year 1979 (11 suicides, 10 of which occurred in prison hospitals). A review of the literature indicates that various limitations mentioned in relevant studies lie in the unreliability of data (doubts about the validity of official statistics, missing data in archives, missing files on the victims, suicide in juvenile institutions not always recorded separately, etc.). The research emphasizes the importance of improving suicide statistics (recording, clearing up the incidents of deaths that are recorded without specification of cause, etc.) in order to plan and enforce suicide prevention and intervention strategies that seem to "work" in a particular milieu and are not debatable (e.g., the use of "suicide proof" cells).
THE CASE OF AVIAN INFLUENZA IN TURKEY

ABSTRACT The primary concern of this paper is to inquire about the associations between socio-demographic and psychological variables related to avian influenza in Turkey. The data were collected from a survey given to a sample of 247 females and 223 males from six regions in Turkey. Statistical analysis revealed that gender, education level, and socio-economic status had significant impacts on knowledge, attitudes, and responsible behavior. Participants who were more aware of the impacts of nature made important suggestions at both the national and international level.
Optimising the duration of antibiotic therapy for ventilator-associated pneumonia

Ventilator-associated pneumonia (VAP) has traditionally been treated with a 14–21-day course of antibiotics. However, prolonged antibiotic therapy is associated with the emergence of multidrug-resistant strains, as well as higher toxicity and costs. In a large, randomised, controlled trial in patients with microbiologically confirmed VAP who received appropriate empirical antibiotic therapy, an 8-day antibiotic regimen was not associated with excess mortality or more episodes of recurrent pulmonary infection compared with a 15-day regimen. Amongst patients who developed recurrent infection, multidrug-resistant pathogens emerged less frequently in the group receiving 8 days of antibiotic therapy. The 8-day regimen was also not associated with excess mortality in the subgroup with VAP caused by nonfermentative Gram-negative bacilli, mostly Pseudomonas aeruginosa, although recurrent infections occurred more often. Pending confirmatory studies, an 8-day course of antibiotic therapy may be appropriate for many patients with ventilator-associated pneumonia, providing that initial antibiotic therapy is appropriate, the clinical course is favourable and extreme vigilance is maintained after stopping antibiotics. Patients whose initial treatment regimen was inappropriate, those infected with difficult-to-treat pathogens such as Pseudomonas aeruginosa, and immunocompromised patients and others at high risk for relapse are likely to require a longer duration of antibiotic therapy.
A big-picture look at enterprise architectures

It makes sense to plan the growth of your information systems. But many attempts to create a road map start at the wrong level. Ensuring a consistent, coherent vision to direct the evolution of the enterprise's information systems is difficult enough with a development framework. Without one, it's impossible. The concepts we outline are just a task list in the work to establish an enterprise architecture, but they give you some idea of the breadth of the job ahead of you. However, we hope we've given you a start toward a more realistic vision of your enterprise architecture.
Assessment of the impact of malaria on CD4+ T Cells and haemoglobin levels of HIV-malaria co-infected patients.

INTRODUCTION The human immunodeficiency virus (HIV) and malaria destroy important cells required for proper immunological and haematological functioning of the body. This research therefore aimed to assess the effect of malaria on CD4+ and haemoglobin (Hb) levels of HIV-malaria co-infected patients. METHODOLOGY The study was performed by sampling 220 adult HIV patients on highly active anti retroviral therapy (HAART) who routinely visited the Tema General Hospital in Ghana. Blood samples were obtained for both blood film microscopy identification of malaria parasites and analysis using rapid diagnostic test kits. A BD Facscount Analyzer was used in the quantification of CD4+ levels. RESULTS Of the 220 patients sampled, 34 (15.5%) were HIV-malaria co-infected, all of whom (34; 100%) had CD4+ counts below the normal range, while 23 (12.9%) of the HIV mono-infected patients had normal CD4+ counts. Almost all HIV-malaria co-infected patients (33; 97.1%) had low Hb levels, whereas 79 (42.5%) of the HIV mono-infected patients had normal Hb. Malaria infection strongly correlated positively and significantly with both low CD4+ count (χ2 = 0.828, P = 0.003) and Hb (χ2 = 0.817, P = 0.004) levels. CONCLUSION Malaria co-infection with HIV decreases CD4+ T cells and Hb levels in patients. It is therefore recommended that HIV patients in malaria endemic areas should adhere to malaria preventive measures.
Modified rational function modeling for multi-port high-speed differential circuits

This paper presents a modified rational function modeling technique for multi-port high-speed differential circuit simulations. It models the differential channel and multi- aggressor crosstalk with modified rational functions extracted from the single-ended multi-port S-parameters of the circuit. The multi-port S-parameters of a high-speed circuit can be directly measured or simulated using electromagnetic simulators, and the poles and residues of the modified rational functions are determined by a vector fitting algorithm. Compared to the traditional rational function modeling, far fewer poles are needed to model a channel and crosstalk. With the modified rational function modeling technique, the output signals of the differential channel and crosstalk can be expressed in closed forms, providing a simple way to do quasi-analytic time-domain analysis of multi-port differential structures. The presented modeling technique is demonstrated for a 16-port high-speed electrical backplane.
Rollover Risk, Liquidity and Macroprudential Regulation

I study rollover risk in the wholesale funding market when intermediaries can hold liquidity ex ante and are subject to fire sales ex post. Precautionary liquidity restores multiple equilibria in a global rollover game. An intermediate liquidity level supports both the usual run equilibrium and an efficient equilibrium. I provide a uniqueness refinement to characterize the privately optimal liquidity choice. Because of fire sales, liquidity holdings are strategic substitutes. Intermediaries free ride on the liquidity of other intermediaries, causing excessive liquidation. A macroprudential authority internalizes the systemic nature of liquidity and restores constrained efficiency by imposing a macroprudential liquidity buffer.