Miracle-dz/UniFAR-FTUs huggingface dataset:
A simple biophysical model emulates budding yeast chromosome condensation

Mitotic chromosomes were one of the first cell biological structures to be described, yet their molecular architecture remains poorly understood. We have devised a simple biophysical model of a 300 kb-long nucleosome chain, the size of a budding yeast chromosome, constrained by interactions between binding sites of the chromosomal condensin complex, a key component of interphase and mitotic chromosomes. Comparisons of computational and experimental (4C) interaction maps, and other biophysical features, allow us to predict a mode of condensin action. Stochastic condensin-mediated pairwise interactions along the nucleosome chain generate native-like chromosome features and recapitulate chromosome compaction and individualization during mitotic condensation. Higher order interactions between condensin binding sites explain the data less well. Our results suggest that basic assumptions about chromatin behavior go a long way to explain chromosome architecture and are able to generate a molecular model of what the inside of a chromosome is likely to look like. DOI: http://dx.doi. org/10.7554/eLife.05565. 001
Involving Corporate Functions: Who Contributes to Sustainable Development?

A large body of literature claims that corporate sustainable development is a cross-functional challenge, which requires all functional units to be involved. However, it remains uncertain to what extent and in which way different corporate functions are actually involved in corporate sustainability management. To bridge this research gap, our paper draws on a concept of involvement introduced in the field of consumer behavior. Based on this previous research, our paper distinguishes two components of involvement: first, a cognitive-affective component, incorporating being affected by sustainability issues and being supportive of corporate sustainability; and second, a behavioral component, represented by the application of sustainability management tools. We use this concept to empirically analyze the involvement of corporate functions in sustainability management and find considerable differences in large German companies. Whereas public relations and strategic management are heavily involved, finance, accounting and management control appear not to be involved. A multinomial logistic regression shows that the cognitive-affective component significantly influences the behavioral component, with a functional unit being affected influencing the application of tools the most. Building on the model proposed, the paper provides implications on how to increase a functional unit’s involvement in sustainability management.
Comparison of H-8 and Optimized-LQR Controller in Active Suspension System

The objectives of this paper are to establish the mathematical model and the robust control technique of the active suspension system for a quarter-car model. The aim of a car suspension system is to improve riding quality while handling characteristics subject remain good to uneven or rude road surface. The purpose of designing the controller for the car suspension system is to reduce the traditional design as trade-off between ride comfort and handling by directly controlling the suspension force to road and driving conditions. The H-∞ and LQR controllers are used to reject the effects of road disturbances. H-∞ controller is able to reject the uncertainty of the system and remain the system robustness while road disturbance enter to suspension system. The controller and suspension system performances are simulated to proof the effectiveness of the proposed controllers. Simulink Response Optimization toolbox in matlab is used to optimize the best gain for the controller feedback. The performance of the H-∞ controller is compared with the LQR controller, LQR optimize and the passive suspension systems.
Finding similar faces

In this paper, we propose a method to match similar faces despite photos, which are taken from different sources on Internet, could have different scenes, illumination and posing. Interest points are used to recognize faces, and some points are eliminated in order to find best matching points which pair the similar face. Difference between two matching points is used to define similarity of the faces. Inspite of physical changes due to old age, plastic surgery, make-up or clothing, experiments show that given face image can be successfully matched with a similar face within a database composed of celebrity photos.
Area-based photo-plethysmographic sensing method for the surfaces of handheld devices

Capturing the user's vital signs is an urgent goal in the HCI community. Photo-plethysmography (PPG) is one approach; it can collect data from the finger tips that indicate the user's autonomic nervous system (ANS) and offers new potentials such as mental stress measurement and drowsy state detection. Our goal is to set PPG sensors on the surfaces of ordinary devices such as mice, smartphones, and steering wheels. This will offer smart monitoring without the burden of additional wearable sensors. Unfortunately, current PPG sensors are very narrow, and even if the sensor is attached to the surface of a device, the user is forced to align and hold the finger to the sensor point, which degrades device usability. To solve this problem, we propose an area-based sensing method that relaxes the alignment requirement. The proposed method uses two thin acrylic plates, a diffuser plate and a detection plate, as an IR waveguide. The proposed method can yield very thin sensing surfaces and gentle curvatures are possible. An experiment compares the proposed method to the conventional point-sensor in terms of LF/HF discrimination performance with the participant in the resting state, and the proposed method is shown to offer comparable sensing performance with superior usability.
Identification of novel single nucleotide polymorphisms in the DGAT1 gene of buffaloes by PCR-SSCP

Diacylglycerol O-acyltransferase 1 (DGAT1) is a microsomal enzyme that catalyzes the final step of triglyceride synthesis. The DGAT1 gene is a strong functional candidate for determining milk fat content in cattle. In this work, we used PCR-SSCP (polymerase chain reaction-single-strand conformation polymorphism) and DNA sequencing to examine polymorphism in the region spanning exon 7 to exon 9 of the DGAT1 gene in Murrah and Pandharpuri buffaloes. Three alleles (A, B and C) and four novel single-nucleotide polymorphisms were identified in the buffalo DGAT1 gene. The frequencies of the alleles differed between the two buffalo breeds, with allele C being present in Murrah but not in Pandharpuri buffalo. The allele variation detected in this work may influence DGAT1 expression and function. The results described here could be useful in examining the association between the DGAT1 gene and milk traits in buffalo.
The Application of Task-Driven Teaching Method

In order to improve students' information accomplishment and computer application skill, Task-driven teaching method is applied in the computer course. By designing tasks which are close to students' life, Task-driven teaching method help students to analyze the task, instruct them to finish the task, and evaluate the task and students' work in time. The result shows that it works well and can arouse the learning interest of students and train students' ability of practice, the spirit of innovation and teamwork. It must be noticed that the difficulty of the task must be appropriate, and the design of the task should be hierarchical, the method must not be misused, enough attention must be paid to the negative effects.
Power Control-Based Multi-User Li-Fi Using a Compound Eye Transmitter

In visible light communications (VLC), the transmitted signal is non-negative and real valued, and these characteristics constrain the signal space and provide new challenges for waveform design in a multi-user system. In Light Fidelity (Li- Fi), a VLC technology, and similar to radio frequency (RF) systems, precoder designs can be used to serve multiple users. However, a signal shaping algorithm is required to address the non-negativity of the transmitted signal in Li-Fi. In this study, a power allocation algorithm is proposed to achieve a multi-user Li-Fi system. A compound eye transmitter consisting of several LEDs pointing in different directions is used. This means that the process of the obtaining the inverse of the channel matrix in precoder design is not required. Results show that when a 30^o semi-angle is used at the transmitter and the system has 4 users, the proposed transmission model can achieve 10^−5 average bit error rate (BER) performance at 1 dBm average transmission power.
Fast-Lock Dual Charge Pump Analog DLL using Improved Phase Frequency Detector

In this paper, a dual charge pump architecture for fast-lock low-jitter analog delay-locked loop (DLL) is proposed and analyzed. The proposed fast lock analog DLL takes up less area compared to other similar fast lock analog DLL due to the reduction of the number of phase frequency detector (PFD) used in the design. An improved PFD is proposed to reduce the output jitter by reducing the one-shot pulse produced when the reference signal and output signal is in phase. The proposed DLL circuit is designed based on the Silterra 0.18-mum 1P6M CMOS process with a 1.8-V supply voltage. The active area of the proposed DLL circuit is 327.46 mum x 116.16 mum. An experimental chip was implemented and measured. The measurement results show that the proposed DLL has fast locking and low jitter properties.
Multicast and unicast video streaming with rateless channel-coding over wireless broadband

Prior research on wireless multicast video streaming has addressed the risk of feedback implosion when providing adaptive forward error correction (FEC). This approach has not been adopted by providers, who may either stick to unicast streaming or use a sufficient level of application layer FEC to avoid the need for adaptation. Instead in this paper, an adaptive unicast rateless channel coding scheme is also run in multicast mode. This is accomplished simply by turning off requests for FEC repair data. The paper demonstrates the concept and provides an indication of the operating conditions for such a joint multicast/unicast service in terms of data rates and suitable video content type.
Improved multistage decoding of multilevel codes for digital radio mondiale (drm)

The new digital radio standard Digital Radio Mondiale (DRM) uses multilevel coding as channel coding. A very effective decoding algorithm is the iterative multi- stage decoder (MSD). In our paper we analyze different implementations of the MSD utilizing hard-decision with different metrics. The performance of these implementa- tions is evaluated by computer simulations. Additionally, an MSD with soft-decision (Max-Log-MAP) is investigated and serves as a benchmark for the hard-decision algorithms.
Gameplay evaluation of the trackball controller

We present a study of user performance in a First Person Shooter game comparing a prototype trackball controller, a standard game controller, and a keyboard and mouse. The prototype controller replaces the right analog stick of a standard game controller (used for pointing and camera control) with a trackball. To measure the performance of the three input devices, participants played two games. Penguin Hunt measured the number of target hits per minute, which was 28.1 with the keyboard and mouse, 22.9 with the trackball controller, and 21.7 with the standard controller. Modern Warfare measured average completion times, which were 26.8 s with the keyboard and mouse, 31.8 s with the trackball controller and 35.5 s with the standard controller. The trackball controller represents a 5.5% target hits increase over the standard controller in Penguin Hunt, and a 10.4% speed-up in trial completion time in Modern Warfare.
Robust Wireless Image Communications Using Combined SPIHT/OFDM Technique

In this paper, we propose a combined SPIHT/OFDM coding scheme for transmission of image/video over wireless fading channels. The proposed system implements a rate control algorithm as the image coding scheme and an adaptive modulation OFDM system as the communication coding scheme. We evaluate the system over uncorrelated Rayleigh fading channel. Simulation results for Peak Signal-to-Noise Ratio (PSNR) of the received image at different rates are presented which demonstrate the contribution of our algorithm over this challenging channel.
Going Beyond Instrument Interactions: Towards a More Comprehensive Policy Mix Conceptualization for Environmental Technological Change

Reaching a better understanding of the policies and politics of transitions presents a main agenda item in the emerging field of sustainability transitions. One important require- ment for these transitions, such as the move towards a decarbonized energy system, is the redirection and acceleration of technological change, for which policies play a key role. Several studies of policies supporting environmental technological change have ar- gued for the need to combine different policy instruments in so-called policy mixes. However, existing policy mix studies often fall short of reflecting the complexity and dy- namics of actual policy mixes and the underlying politics of (re)designing them. In this paper we take a first step towards a more comprehensive, interdisciplinary policy mix concept for environmental technological change based on a review of the bodies of lit- erature on innovation studies, environmental economics and policy analysis. The concept introduces a clear terminology and consists of the three building blocks elements, proc- esses and characteristics, which can be delineated by several dimensions. Throughout the paper, we illustrate the concept using the example of the policy mix for fostering the transition of the German energy system to renewable power generation technologies. We argue that the proposed concept provides an integrating analytical framework for empirical studies analyzing the impact of the policy mix on environmental technological change and sustainability transitions more broadly. Finally, we derive policy implications and suggest avenues for future research.
A New Comparative Metric for Estimating Heterothermy in Endotherms

A major focus in the study of endothermic thermoregulation has been the description of thermoregulatory patterns used by various species and/or populations. Compared with ectotherms, relatively few attempts have been made to study the thermoregulation of endotherms in an adaptive framework. We believe that one of the main factors limiting this area of research has been the lack of an appropriate metric to directly compare body temperature (Tb) variation across all endothermic species. Thus, we present a simple comparative metric, the heterothermy index (HI), to quantify the expression of heterothermy by endotherms during a given time frame. Key advantages of HI are that (1) it represents a new analytical technique that has different strengths than the metrics commonly used to describe variation in Tb, (2) it allows for evaluation of nonenergetic costs and benefits that affect the expression of heterothermy, and (3) it has the potential to unify research on homeotherms and heterotherms through quantitative comparative analyses that examine the entire continuum of thermoregulatory patterns. In short, we suggest that our metric provides a means to overcome one of the hurdles presently slowing the advancement of research on endothermic thermoregulation beyond the simple description of thermoregulatory patterns.
Modular d-q frame small-signal modelling and analysis of a microgrid

In this paper, a systematic, scalable small-signal modelling approach for microgrids is described. First, each subsystem is modelled separately, and then all are interfaced using Simulink Control Design Toolbox. The main advantage of this method is its practicality, as analytical models of whole microgrids are derived systematically and easily. A real microgrid is modelled and the presented method is applied to perform analysis both at subsystem-level (control design) and at system-level (microgrid stability). Also, experimental operation of the microgrid is illustrated.
Analysis of a slit die rheometer: Predicting product flow and dimensions through numerical simulation

Three-dimensional modelling of flow in a two channel slit die rheometer (Vergnes et al, 1993) fitted to a twin-screw extruder has been modelled with the finite element method. The twin channel design means that the rheometer can be used to study the rheological behaviour of materials that are sensitive to thermo-mechanical changes, such as starchy products, since local shear rate within the channels can be varied without changing the flow condition in the extruder. This paper presents a method of numerical simulation that provides insight into conditions within an on-line slit die (i.e. a streamline concept for obtaining die pressure and velocity profiles, local shear rate and viscosity) and also predicts the product dimension after exit from the die. Experimental data collected with the slit die rheometer was used to determine the correlation between shear rate and apparent viscosity, calculated via a power law equation, and was used as a modelling input. On-line measurements made with the slit die rheometer provide valuable rheological data about extruded products. This data can be used for rheological modelling of flow extruder dies, allowing for more efficient die design process.
Flexible and high-performance anonymization of NetFlow records using anontool

Netflow is a protocol widely adopted by the security and performance measurements community. Nowadays, many distributed applications and architectures base their functionality on Netflow data collected at diverse environments. However, communities and administrators are reluctant to share exported Netflow data for privacy reasons. As a consequence, the effectiveness of distributed approaches is limited due to lack of input data. To overcome this limitation, anonymization on Netflow data is proposed for sharing. However, the available tools are either proprietary or of very limited functionality. Towards this direction, we propose and implement anontool, that allow administrators to anonymize Netflow data in a highly customizable way. A comparison of anontool with existing solutions is provided along two dimensions: functionality and performance. Anontool can anonymize traffic even at high bandwidth rates, outperforming most of the tools and having same performance with specialized - but very limited in functionality - approaches.
Application of a Two-Dimensional Hindmarsh-Rose Type Model for bifurcation Analysis

In this study, we examine the bifurcation scenarios of a two-dimensional Hindmarsh–Rose type model [Tsuji et al., 2007] with four parameters and simulate some resemblances of neurophysiological features for this model using spike-and-reset conditions. We present possible classifications based on the results of the following assessments: (1) the number and stability of the equilibria are analyzed in detail using a table to demonstrate the matter in which the stability of the equilibrium changes and to determine which two equilibria collapse through the saddle-node bifurcation; (2) the sufficient conditions for an Andronov–Hopf bifurcation and a saddle-node bifurcation are mathematically confirmed; and (3) we elaborately evaluate the sufficient conditions for the Bogdanov–Takens (BT) and Bautin bifurcations. Several numerical simulations for these conditions are also presented. In particular, two types of bistable behaviors are numerically demonstrated: the BT and Bautin bifurcations. Notably, all of the bifurcation curves in the domain of the remaining parameters are similar when the time scale is large. Additionally, to show the potential for a limit cycle, the existence of a trapping region is demonstrated. These results present a variety of diverse behaviors for this model. The results of this study will be helpful in assessing suitable parameters for fitting the resemblances of experimental observations.
Oncotargets and Therapy Dovepress Dovepress Materials and Methods Patients and Tissue Samples

hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms increased expression of the long noncoding rna crnDe-h indicates a poor prognosis in colorectal cancer, and is positively correlated with irX5 mrna expression Background: The long noncoding RNA (lncRNA) colorectal neoplasia differentially expressed – h (CRNDE-h) plays important roles in the early stages of human development and cancer progression. We investigated the expression and clinical significance of lncRNA CRNDE-h in colorectal cancer (CRC). Methods: The expression level of lncRNA CRNDE-h was analyzed in 142 CRC tissues and 142 paired adjacent nontumorous tissues, along with 21 inflammatory bowel diseases, 69 hyperplastic polyp, and 73 colorectal adenoma samples, using quantitative real-time poly-merase chain reaction. The association between lncRNA CRNDE-h, and Iroquois homeobox protein 5 (IRX5) mRNA was examined in the same 142 CRC tissues. Results: We found that lncRNA CRNDE-h level was elevated in the CRC and adenoma groups compared with the other groups (all at P,0.001). In CRC, upregulation of lncRNA CRNDE-h was significantly correlated with large tumor size, positive regional lymph node metastasis, and distant metastasis (all at P,0.05). Area under the curve for lncRNA CRNDE-h showed diagnostic capability for distinguishing CRC from other groups. Patients with CRC with high lncRNA CRNDE-h expression level had poorer overall survival than those with low lncRNA CRNDE-h expression (log-rank test, P,0.001). Further, multivariable Cox regression analysis suggested that increased expression of lncRNA CRNDE-h was an independent prognostic indicator for CRC (hazard ratio [HR]=2.173; 95% confidence interval [CI], 1.282–3.684, P=0.004). Furthermore, lncRNA CRNDE-h expression was positively correlated with IRX5 mRNA in CRC tissues. Conclusions: Our data offers convincing evidence for the first time that lncRNA CRNDE-h is associated with adverse clinical characteristics and poor prognosis, which suggests that it might play an important role in CRC development and progression and might have clinical potential as a useful prognostic predictor. Introduction Colorectal cancer (CRC) is one of the most common malignant tumors and the third leading cause of cancer deaths worldwide. 1 Although current detection methods, such as fecal occult blood testing and fiber-optic colonoscopy, have significantly improved outcomes for patients with CRC, more than half of those at an advanced stage of disease die of carcinoma recurrence after undergoing radical resection. …