Miracle-dz/UniFAR-FTUs huggingface dataset:
A novel sound-blocking structure based on the muffler principle for rib-sparing transcostal high-intensity focused ultrasound treatment

Abstract The main challenge in transcostal high-intensity focused ultrasound therapy is minimising heat deposition in the ribs while ensuring that a sufficient dose is delivered to the target region. Current approaches rely on expensive multichannel phased-array systems to turn the individual transducer on and off according to either geometrical arrangements or complicated wave calculations. To protect the ribs from heating, the ultrasound energy must not only not reach the ribs, but must also not accumulate in front of the ribs. The research in this paper proposes a different approach, of attaching a sound-blocking structure in front of the rib cage with similar effects to those of an engine exhaust muffler. The sound-blocking structure is based on the muffler principle to prevent ultrasound energy from reaching the ribs and reduce the amount of energy reflected back to the applicator. Finite element simulations with a 0.5-MHz transducer of the overall sound fields and temperature distribution showed that the ultrasound pressure and energy level would decrease behind the novel sound-blocking structures, thereby resulting in a lower temperature at the ribs than at the tumour. Without the protecting structure, the rib temperature reached 104.19 °C whereas with the structure it reached only 37.86 °C. An experimental set-up using porcine ribs with a phantom was also developed to validate the concept, which showed that the rib temperature reached 73 °C without protection within 1 min of ablation time whereas it reached 36.5 °C with the device. The tumour region in the tests reached 51 °C and 49 °C with and without protection, respectively.
Design and implementation of Remote Terminal Unit on Mini Monitoring Weather Station Based on Microcontroller

In the previous research, a single master-multi slave microcontroller communication method has been developed. The microcontroller is able to communicate using unicast communication, i.e. the master gave orders to one slave address via the master-slave network that has star topology. Then the slave who has the same address which is requested will respond or take action in accordance with the master command. This paper will explain the use of a single master — multi slave communication method in a Remote Terminal Unit (RTU) of Mini Monitoring Weather Station Based on Microcontroller.
Anti‐c‐MET Nanobody® – a new potential drug in multiple myeloma treatment

c‐MET is the tyrosine kinase receptor of the hepatocyte growth factor (HGF). HGF‐c‐MET signaling is involved in many human malignancies, including multiple myeloma (MM). Recently, multiple agents have been developed directed to interfere at different levels in HGF‐c‐MET signaling pathway. Nanobodies® are therapeutic proteins based on the smallest functional fragments of heavy‐chain‐only antibodies. In this study, we wanted to determine the anticancer effect of a novel anti‐c‐MET Nanobody in MM.
Beam scanning characteristics of microstrip triangular array antenna on normally biased NiAl ferrite

A conventional 4×4 planar microstrip equilateral triangular array antenna (METAA) is designed on a NiAl biased ferrite substrate in the C-band (5 GHz) region. The antenna shows tunability in resonant frequency, bandwidth, and efficiency and radiation conductance on application of an external magnetic field normal to the plane of the array geometry. The radar cross-section (RCS) characteristics, especially the resonance behavior of the array with various bias conditions, are studied and compared to the case of an unbiased ferrite. It is investigated that the RCS can be moved with respect to frequency by changing the magnetic bias field. It is also found that magnetic losses affect the RCS at resonance significantly.
Machine vision based fire flame detection using multi-features

Video fire detection has many advantages over traditional methods, such as fast response, non-contact. But most of current methods for video fire detection have high rates of false alarms. In point of general fires, the flames usually display reddish colors. And as an important physical feature of fire, the flame turbulent has a chaotic nature with abundant size and shape variation. If we consider the flame is made up of lots of spots, as a result of the turbulent movement, the spots' velocity vector will be different from each other. A novel video fire flame detection method based on color and dynamic features is presented. The method is proposed as followed, first, candidate fire regions are determined by frame differential method and a flame color model. Then, a pyramidal Lucas Kanade feature tracker is used to calculate the velocity vectors of the feature points of the fire candidate regions. Finally, examples consisting of features extracted from sequences of off-line videos are collected for the training of a discriminating model which is used to differentiate fire from some other moving objects. Experiments show that the algorithm has fast response and encouraging false alarm rate for fire flame detection.
Preliminary assessment of whole‐blood, red‐cell and platelet‐ leucodepleting filters for possible induction of prion release by leucocyte fragmentation during room temperature processing

Universal leucodepletion is being introduced in the U.K. to reduce a theoretical risk of Creutzfeldt‐Jakob disease (CJD) transmission. If CJD infectivity is associated with leucocytes, any cell fragmentation associated with filtration could reduce the potential benefit. Four types each of whole blood, red cell and platelet leucodepletion filters were assessed after holding of blood units for at least 4 h at 22°C. In all cases the mean residual leucocyte content was <1 000 000 per unit, with only two individual filtered whole blood units having a leucocyte content exceeding this. Evidence of leucocyte fragmentation during filtration was sought but not found by assay of soluble elastase, beta‐thromboglobulin and normal prion protein, as well as by isotopic labelling of leucocyte external membrane. These preliminary studies indicate that it was possible to prepare leucodepleted blood components by filtration at room temperature, and that this appeared not to be associated with overt cell fragmentation. Definitive demonstration that fragmentation does not occur requires the development of improved general (non‐specific) assays for cell membrane fragments.
Location Aware Computing

Location aware computing are the ability to find the geographical location of the mobile device and provide services based on this location i information, and now many researchers consider location aware to be the key concept of mobile computing environment. In this paper, we discuss about the basic concept of location aware computing, its technical methods and architectures, case study, brief outlook, and challenges and issues.
GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis

Tumour cell migration and adhesion constitute essential features of metastasis. G‐protein coupled receptor 55 (GPR55), a lysophospholipid receptor, has been shown to play an important role in carcinogenesis. Here, we investigated the involvement of GPR55 in migration and metastasis of colon cancer cells.
OPC: A Distributed Computing and Memory Computing-Based Effective Solution of Big Data

The Big Data computing is one of hot spots of the internet of things and cloud computing. How to compute efficiently on the Big Data is the key of improving performance. By means of distributed computing or memory computing, many companies and institutions provide some technologies and produces. But they are invalid in the scene in which there are real-time demands in the low-configure cluster. To deal with the problem, this paper provides a distributed computing and memory computing-based effective solution (Objectification Parallel Computing, OPC). In the solution, the data can be formatted into object. Then the objects are distributed stored in the computer memories and parallel compute to complete tasks. The OPC is applied to the Electric Asset Quality Supervision Manage System (EAQSMS) of State Grid of China, the result shows that with PCs the system is efficiently available, reliable, and flexible expansible.
Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent.

Silver nanoparticles (AgNPs) are incorporated into medical and consumer products to exploit their excellent antimicrobial properties; however, potential mechanisms of toxicity of AgNPs in mammalian cells are not fully understood. The objective of this study was to determine the mechanism of size- and concentration-dependent cytotoxicity of AgNPs in human liver-derived hepatoma (HepG2) cells. Mechanisms of toxicity were explored at subcytotoxic concentrations (≤10 µg/ml AgNPs) and autophagy induction, lysosomal activity, inflammasome-dependent caspase-1 activation, and apoptosis were examined. Using enhanced dark-field light microscopy, hyperspectral imaging, electron microscopy, and energy dispersive X-ray spectroscopy, AgNPs were shown to rapidly accumulate in cytoplasmic vesicles for up to 24 h and 10-nm AgNPs exhibited the highest uptake and accumulation. Autophagy and enhanced lysosomal activity were induced at noncytotoxic concentrations (1 µg/ml; primary particle size:10 > 50 >100 nm), whereas increased caspase-3 activity (associated with apoptosis) was observed at cytotoxic concentrations (10, 25, and 50 µg/ml). Subcytotoxic concentrations of AgNPs enhanced expression of LC3B, a pro-autophagic protein, and CHOP, an apoptosis inducing ER-stress protein, and activation of NLRP3-inflammasome (caspase-1, IL-1β). Disrupting the autophagy-lysosomal pathway through chloroquine or ATG5-siRNA exacerbated AgNPs-induced caspase-1 activation and lactate dehydrogenase release, suggesting that NLRP3-inflammasome plays an important role in AgNPs-induced cytotoxicity. Overall, 10-nm AgNPs showed the highest cellular responses compared with 50- and 100-nm AgNPs based on equal mass dosimetry. The results indicate the potential of vesicle-engulfed 10-nm AgNPs to induce cytotoxicity by a mechanism involving perturbations in the autophagy-lysosomal system and inflammasome activation.
A Location Estimation Algorithm Based on RSSI Vector Similarity Degree

We present a detailed study on the RSS-based location techniques in wireless sensor networks (WSN). There are two aspects in this paper. On the one hand, the accurate RSSI received from nodes is the premise of accurate location. Firstly, the distribution trend of RSSI is analyzed in this experiment and determined the loss model of signal propagation by processing experimental data. Secondly, in order to determine the distance between receiving nodes and sending nodes, Gaussian fitting is used to process specific RSSI at different distance. Moreover, the piecewise linear interpolation is introduced to calculate the distance of any RSSI. On the other hand, firstly, the RSSI vector similarity degree (R-VSD) is used to choose anchor nodes. Secondly, we designed a new localization algorithm which is based on the quadrilateral location unit by using more accurate RSSI and range. Particularly, there are two localization mechanisms in our study. In addition, the generalized inverse is introduced to solve the coordinates of nodes. At last, location error of the new algorithm is about 17.6% by simulation experiment.
The semantics of the Vilamovicean verbal system ? Part 1 (empirical study)

The present study – divided into two papers – provides an analysis of the semantics of the Vilamovicean verbal system within a cognitive and grammaticalization framework. On the one hand, the author offers a detailed description of the entire semantic potential of all the verbal constructions available in the language and, on the other, provides an explanation for the senses conveyed by each one of these forms – more specifically, it is demonstrated that the semantic sphere of every gram can be explained and, hence, unified by making use of typologically common evolutionary scenarios, viz. paths. Consequently, the author shows that the entire Vilamovicean verbal system can be modeled as a recursive process of grammaticalisation “waves” whereby older and newer forms evolve along a set of identical paths. This article constitutes the first part of the series. It includes a discussion of methodological issues and an empirical study in which the semantic potentials of all the Vilamovicean verbal grams are determined.
Cloning and expression of the ltf gene of bacteriophage T5

The unique 5-kilobase BamHI fragment of bacteriophage T5 was cloned into plasmid pBR322. Location of the intact ltf gene on the cloned fragment was demonstrated by complementation of the ltf mutation of phage T5hd-2, identification of a plasmid-coded polypeptide of the same molecular weight as the polypeptide forming the L-shaped tail fibers, which binds to anti-T5 antibodies; and analyses of transposon Tn1000 insertions.
A Fast Algorithm for Multiprocessor Scheduling of Unit-Length Jobs

An efficient polynomial time algorithm for the problem of scheduling n unit length jobs with rational release times and deadlines on m identical parallel machines is presented. By using preprocessing, a running time of $O(mn^2 )$ is obtained that is an improvement over the previous best running time of $O(n^3 \log \log n)$. The authors also present new NP-completeness results for two closely related problems.
A novel method for comparing 3D target volume delineations in radiotherapy

When comparing delineations it is often useful to obtain a local measure of distance between the volume surfaces. Commonly used methods for analysing local distance exhibit fundamental drawbacks which may cause overestimation of the distance or lead to asymmetry in the measure. This paper describes a new method that aims to solve these problems. The new method finds corresponding points between two delineations by traversing a vector field based on the combined gradient of the distance transforms. The proposed method provides a fundamentally more reliable, symmetric measure of distance. This is supported by an illustrative example of observer variation in prostate delineation. An implementation of the method is available on request to the author.
Calcium Accretion in Girls and Boys During Puberty: A Longitudinal Analysis

The primary purpose of this study was to estimate the magnitude and variability of peak calcium accretion rates in the skeletons of healthy white adolescents. Total‐body bone mineral content (BMC) was measured annually on six occasions by dual‐energy X‐ray absorptiometry (DXA; Hologic 2000, array mode), a BMC velocity curve was generated for each child by a cubic spline fit, and peak accretion rates were determined. Anthropometric measures were collected every 6 months and a 24‐h dietary recall was recorded two to three times per year. Of the 113 boys and 115 girls initially enrolled in the study, 60 boys and 53 girls who had peak height velocity (PHV) and peak BMC velocity values were used in this longitudinal analysis. When the individual BMC velocity curves were aligned on the age of peak bone mineral velocity, the resulting mean peak bone mineral accrual rate was 407 g/year for boys (SD, 92 g/year; range, 226–651 g/year) and 322 g/year for girls (SD, 66 g/year; range, 194–520 g/year). Using 32.2% as the fraction of calcium in bone mineral, as determined by neutron activation analysis (Ellis et al., J Bone Miner Res 1996;11:843‐848), these corresponded to peak calcium accretion rates of 359 mg/day for boys (81 mg/day; 199–574 mg/day) and 284 mg/day for girls (58 mg/day; 171–459 mg/day). These longitudinal results are 27–34% higher than our previous cross‐sectional analysis in which we reported mean values of 282 mg/day for boys and 212 mg/day for girls (Martin et al., Am J Clin Nutr 1997;66:611‐615). Mean age of peak calcium accretion was 14.0 years for the boys (1.0 years; 12.0‐15.9 years), and 12.5 years for the girls (0.9 years; 10.5‐14.6 years). Dietary calcium intake, determined as the mean of all assessments up to the age of peak accretion was 1140 mg/day (SD, 392 mg/day) for boys and 1113 mg/day (SD, 378 mg/day) for girls. We estimate that 26% of adult calcium is laid down during the 2 adolescent years of peak skeletal growth. This period of rapid growth requires high accretion rates of calcium, achieved in part by increased retention efficiency of dietary calcium.
Sentence structure-based summarization for Indonesian news articles

Automatic multi-document summarization may help news readers retrieve information from digital news media efficiently. The summarizer create a concise summary containing important information from a collection of articles, enabling readers to read only one text to gain information from multiple text sources. Reflecting on previous researches, we propose an automatic summarization system using sentence structure information (subject, object, predicate, complement). The system consists of four main components, preprocessing and feature extraction, sentence structure information extraction, sentence clustering and fusion, and sentence selection. The system will extract the necessary information using dependency tree, cluster sentences using Density Based Spatial Clustering for Application with Noise (DBSCAN), fuse sentences with sentence structure information graph, and select sentences using Maximal Marginal Relevance (MMR). The evaluation shows that the proposed system performs with 0.276 average ROUGE-2, with many chances of improvements. Sentence structure extractor has 0.75 f1-measure score.
Small vertex‐transitive and Cayley graphs of girth six and given degree: an algebraic approach

We examine the existing constructions of the smallest known vertex‐transitive graphs of a given degree and girth 6. It turns out that most of these graphs can be described in terms of regular lifts of suitable quotient graphs. A further outcome of our analysis is a precise identification of which of these graphs are Cayley. We also investigate higher level of transitivity of the smallest known vertex‐transitive graphs of a given degree and girth 6 and relate their constructions to near‐difference sets. © 2010 Wiley Periodicals, Inc. J Graph Theory 68:265‐284, 2011
Time in concentration: a simple technique for the accurate detection of resistance to insecticides in mosquito larvae.

Recently, criticism has been directed at the tests recommended by the WHO Expert Committee on Insecticides for the detection of resistance to insecticides in larval populations of mosquitos-by Doby & Corbeau a and Hamon & Garrett-Jones,b for instance. These criticisms concern the reliability of the tests to detect resistance in a population, especially where the resistance is not pronounced or well developed, and question the actual validity of the results obtained by the WHO Expert Committee method. Unfortunately, the alternative techniques or modifications suggested by the above authors are complex, and require observations on mortality to be made over a considerably longer period of time than the methods currently recommended by the WHO highly efficient; ina population containing individuals homozygous for dieldrin-resistance, heterozygous, or homozygous for dieldrin-susceptibility, the phenotype ofeach individual may be accurately determined. Although the work to date has been primarily restricted to the determination of the genotypes for dieldrinand gamma-HCH-resistance, preliminary tests indicate that comparable results may be expected using DDT. The technique herein suggested consists in placing larvae in a single concentration of insecticide for a period of 24 hours. It has been determined that larvae of different genotypes will survive for differential lengths of time in a given concentration (8 ppm) of dieldrin, and that the percentages and curves of mortality reflect accurately the known genotypes
Evaluation of Docker as Edge computing platform

High latency, network congestion and network bottleneck are some of problems in cloud computing. Moving from centralized to decentralized paradigm, Edge computing could offload the processing to the edge which indirectly reduces application response time and improves overall user experience. This paper evaluate Docker, a container based technology as a platform for Edge Computing. 4 fundamental criteria were evaluated 1) deployment and termination, 2) resource & service management, 3) fault tolerance and 4) caching. Based on our evaluation and experiment Docker provides fast deployment, small footprint and good performance which make it potentially a viable Edge Computing platform.
A Comprehensive Network Security Risk Model for Process Control Networks

The risk of cyber attacks on process control networks (PCN) is receiving significant attention due to the potentially catastrophic extent to which PCN failures can damage the infrastructures and commodity flows that they support. Risk management addresses the coupled problems of (1) reducing the likelihood that cyber attacks would succeed in disrupting PCN operation and (2) reducing the severity of consequences in the event of PCN failure or manipulation. The Network Security Risk Model (NSRM) developed in this article provides a means of evaluating the efficacy of candidate risk management policies by modeling the baseline risk and assessing expectations of risk after the implementation of candidate measures. Where existing risk models fall short of providing adequate insight into the efficacy of candidate risk management policies due to shortcomings in their structure or formulation, the NSRM provides model structure and an associated modeling methodology that captures the relevant dynamics of cyber attacks on PCN for risk analysis. This article develops the NSRM in detail in the context of an illustrative example.
2-{1-[2-(Bis{2-[1-(5-chloro-2-hydroxyphenyl)ethylideneamino]ethyl}amino)ethyliminio]ethyl}-4-chlorophenolate toluene hemisolvate

In the toluene hemisolvated tripodal tris(2-aminoethyl)amine Schiff base, C30H33Cl3N4O3·0.5C7H8, one of the three imino N atoms is protonated, forming a hydrogen bond with the O atom at an adjacent benzene ring. The other two imino N atoms act as hydrogen-bond acceptors from phenolate OH groups. The toluene solvent molecule is disordered about a centre of inversion.
Genetic structure and gene flow in French populations of two Ostrinia taxa: host races or sibling species?

Most models of ecological speciation concern phytophagous insects in which speciation is thought to be driven by host shifts and subsequent adaptations of populations. Despite the ever‐increasing number of studies, the current evolutionary status of most models remains incompletely resolved, as estimates of gene flow between taxa remain extremely rare. We studied the population genetics of two taxa of the Ostrinia genus — one feeding mainly on maize and the other on mugwort and hop — occurring in sympatry throughout France. The actual level of divergence of these taxa was unknown because the genetic structure of populations had been investigated over a limited geographical area and the magnitude of gene flow between populations had not been estimated. We used 11 microsatellite markers to investigate the genetic structure of populations throughout France and the extent of gene flow between the two Ostrinia taxa at several sites at which they are sympatric. We observed clear genetic differentiation between most populations collected on the typical respective hosts of each taxon. However, populations displaying intermediate allelic frequencies were found on hop plants in southern France. Individual assignments revealed that this result could be accounted for by the presence of both taxa on the same host. Gene flow, estimated by determining the proportion of hybrids detected, was low: probably < 1% per generation, regardless of site. This indicates that the two Ostrinia taxa have reached a high level of genetic divergence and should be considered sibling species rather than host races.