Miracle-dz/UniFAR-FTUs huggingface dataset:
Career Selection Behavior: Individual Perceptions and Counseling Effectiveness for Career Roles

The study intends to measure the significance of the relationship between counseling and career success. Career success been measured through career outcome and taken as endogenous variable while individual, value & recognition, counseling and organization were taken as exogenous variables. Sample included 173professionals from service industry i.e. faculty of academic institutes and executive level personnel of different organizations. Questionnaire technique was used for data collection. For accurate measurement of factors used in the study model Confirmatory Factor Analysis (CFA) and Structural Equation Modeling (SEM) being applied. The conclusion of this study indicated that counseling have a greater impact on building a person’s confidence about his talents and deriving value system for professional life. Results also indicated that if mis-match exists between capabilities and professional roles then loyalty, commitment and performance can be declined. This indicates that individuals are not performing according to their interests and there may be some career problem exists. This problem can be diagnosed through counseling system and alignments of individual goals with organizational goals should be applied. Thus organizations should recognize importance of counseling phenomena and consider the career development needs of employees as it creates synergic impact on organizational performance.
Decision Making and Aggression in Forensic Psychiatric Inpatients

This study provides initial empirical support for a novel neurobiological decision-making model proposed by Nussbaum (2005), applied to an aggression typology (Nussbaum, Saint-Cyr, & Bell, 1997). The Iowa Gambling Task (IGT; Bechara, Damasio, Damasio, & Anderson, 1994) was analyzed for forensic inpatients using both the traditional method of scoring reflecting motivational decision making and a novel method developed by Yechiam, Busemeyer, Stout, and Bechara (2005) that provides scores for three cognitive decision-making components: attention, learning, and response-choice consistency. Predatory seclusions were predicted by traditional motivational scoring of the IGT but not by the cognitive scores. Conversely, Irritable seclusions were predicted only by the cognitive scoring system. Based on these findings, the utilization of the aggression typology and the inclusion of these clinical measures could enhance and refine violent risk assessment, suggest specific treatment targets for different aggression types, and monitor responses to interventions prior to release into the community.
Redox Switch of Hsp33 Has a Novel Zinc-binding Motif*

The chaperone activity of the heat shock protein Hsp33 is regulated by reversible disulfide bond formation. Oxidized Hsp33 is active, and reduced Hsp33 is inactive. We show that zinc binding is essential for the function of this redox switch. Our results reveal that Hps33 contains a new, high affinity (K a > 1017 m − 1), zinc-binding motif in the form Cys-X-Cys-X 27–32-Cys-X-X-Cys. All four conserved cysteines within this motif act to coordinate a single zinc atom. Experiments where reduced wild type Hsp33 is reconstituted with cobalt or cadmium demonstrate that the metal-coordinating cysteines are present as highly reactive thiolate anions. This ionization may allow for the fast and successful activation of the chaperone function of Hsp33 upon incubation in oxidizing agents.
[1R-(1α,2α,4α,5β,6α,7α)]-4-Benzoyloxymethyl-5,6-dihydroxy-3,8-dioxatricyclo[5.1.0.02,4]octan-5-yl acetate (3-deacetylcrotepoxide) from Kaempferia rotunda Val.

The title compound, C16H16O7, isolated from Kaempferia rotunda rhizomes, features a six-membered cyclohexane ring that adopts a twisted-boat conformation owing to the presence of two adjacent epoxide attachments that lock in four of the six axial positions. The CH3CO2– and HO– substituents occupy equatorial positions. However, the bond angles at the ring carbon connected to the C6H5CO2CH2– substituent deviate signifcantly from the idealized tetrahedral angles as the carbon atom is part of an epoxide ring. In the crystal, the molecules are linked into chains by O—H⋯O hydrogen bonds.
Different role of CD30 in the development of acute and chronic airway inflammation in a murine asthma model

CD30 is a costimulatory molecule of the TNF receptor superfamily, expressed on activated T and B cells. Previously, we have shown in a murine asthma model the crucial role of CD30 signaling for the development of this Th2‐cell‐mediated disease. In the present study, we investigated the role of CD30 in the maintenance of the immune response. In contrast to the acute model, in the chronic model CD30−/− mice developed a severe asthma‐like phenotype with eosinophilic inflammation and high serum IgE levels. Collagen content, ECM protein deposition and proliferation of smooth muscle cells as signs for airway remodeling were equally increased in both CD30−/− and WT mice. Reduced expression of the costimulatory molecule OX40 on CD3+ T cells in the acute and up‐regulation in the chronic model indirectly supported a compensatory role of OX40 for CD30 signaling. In accordance, application of agonistic OX40 antibody restored the asthma phenotype in CD30−/− mice in the acute model, whereas chronic airway inflammation was reduced in the presence of an inhibitory anti‐OX40 ligand antibody. These data demonstrate that the crucial role of CD30 signaling in the development of acute asthma may be taken over by other costimulatory molecules like OX40 after long‐term exposure to the antigen.
Gonadal mosaicism in ARID1B gene causes intellectual disability and dysmorphic features in three siblings

The gene encoding the AT‐rich interaction domain‐containing protein 1B (ARID1B) has recently been shown to be one of the most frequently mutated genes in patients with intellectual disability (ID). The phenotypic spectrums associated with variants in this gene vary widely ranging for mild to severe non‐specific ID to Coffin–Siris syndrome. In this study, we evaluated three children from a consanguineous Emirati family affected with ID and dysmorphic features. Genomic DNA from all affected siblings was analyzed using CGH array and whole‐exome sequencing (WES). Based on a recessive mode of inheritance, homozygous or compound heterozygous variants shared among all three affected children could not be identified. However, further analysis revealed a heterozygous variant (c.4318C>T; p.Q1440*) in the three affected children in an autosomal dominant ID causing gene, ARID1B. This variant was absent in peripheral blood samples obtained from both parents and unaffected siblings. Therefore, we propose that the most likely explanation for this situation is that one of the parents is a gonadal mosaic for the variant. To the best of our knowledge, this is the first report of a gonadal mosaicism inheritance of an ARID1B variant leading to familial ID recurrence. © 2015 Wiley Periodicals, Inc.
An investigation of subspace modeling for phonetic and speaker variability in automatic speech recognition

This paper investigates the impact of subspace based techniques for acoustic modeling in automatic speech recognition (ASR). There are many well known approaches to subspace based speaker adaptation which represent sources of variability as a projection within a low dimensional subspace. A new approach to acoustic modeling in ASR, referred to as the subspace based Gaussian mixture model (SGMM), represents phonetic variability as a set of projections applied at the state level in a hidden Markov model (HMM) based acoustic model. The impact of the SGMM in modeling these intrinsic sources of variability is evaluated for a continuous speech recognition (CSR) task. The SGMM is shown to provide an 18% reduction in word error rate (WER) for speaker independent (SI) ASR relative to the continuous density HMM(CDHMM) in the resource management CSR domain. The SI performance obtained from SGMM also represents a 5% reduction in WER relative to subspace based speaker adaption in an unsupervised speaker adaptation scenario.
The Development of a Framework to Capture Perceptions of Sport Organizations Legitimacy

In this manuscript, we use Bitektine’s (2011) theory of organizational social judgments to develop a framework to Capture Perceptions of Organizational Legitimacy (CPOL). We outline a three-stage framework as a method to measure the perceived dimensions on which constituents scrutinize a sport organization’s legitimacy. In stage one of the framework, we defined the organizational context of a nonprofit sport organization in Sydney, Australia to establish the classification, purpose, and relationship of the focal entity to its constituents. In stage two, we distributed a qualitative questionnaire (N = 279) to identify the perceived dimensions on which constituents scrutinized organizational action. In stage 3 we distributed a quantitative questionnaire (N = 860) to test six perceived dimensions, which emerged during stage two of the CPOL framework. The six dimensions explained 63% of respondents’ overall organizational judgment, providing support for the CPOL framework as a context-driven process to measure constituent perceptions of the legitimacy of sport organizations.
Age‐related change in the number of neurons in the human vestibular ganglion

Dysequilibrium of aging in humans has been speculated to arise from progressive deterioration within anatomical components of the vestibular system. An integral part of this system is vestibular ganglions, which are bipolar neurons that relay peripheral vestibular information to the central nervous system. To assess the effect of aging on the number of human vestibular ganglion neurons, assumption‐free stereology in the form of the optical fractionator was used on 20 serially sectioned archival human temporal bone specimens. Donors had no history of vestibular pathology and ranged in age from 2 to 88 years. An average of 25,812 (coefficient of variation = 0.13) vestibular ganglion neurons was found throughout this age range, a significant departure from the results of past studies. Logistics‐based regression analysis pointed to a nonlinear pattern of decline in the neuronal population: the number of cells remained roughly constant at about 28,952 cells in youth and then declined gradually between 30 and 60 years of age before leveling off at approximately 23,349 cells in older individuals. This study confirmed the existence of an age‐related decline in the primary neurons of the human vestibular system, thus providing one anatomical basis for the increased incidence of imbalance seen with age. J. Comp. Neurol. 431:437–443, 2001. © 2001 Wiley‐Liss, Inc.
Enhanced Interactive Spiral Display

Spiral displays have been developed to visualize the cyclic character of a data set. They are particularly useful for spotting seasonal patterns in time series data. This, however, requires expressive visual encoding and efficient interaction. In this paper, we improve existing spiral displays by applying the expressive two-tone pseudo coloring. This allows users to read off data values more precisely. More importantly, we enhance our twotone spiral display with efficient interaction facilities. These allow for easy exploration of the data space and easy adjustment of a variety of visualization parameters. Our tool is fully implemented and freely available for experimentation. CR Categories: H.5. 2 [Information Interfaces and Presentation]: User Interfaces—Graphical User Interfaces, Interaction Styles; I.3. 6 [Computer Graphics]: Methodology and Techniques— Interaction Techniques
Salting Public Traces with Attack Traffic to Test Flow Classifiers

We consider the problem of using flow-level data for detection of botnet command and control (C&C) activity. We find that current approaches do not consider timing-based calibration of the C&C traffic traces prior to using this traffic to salt a background traffic trace. Thus, timing-based features of the C&C traffic may be artificially distinctive, potentially leading to (unrealistically) optimistic flow classification results. In this paper, we show that round-trip times (RTT) of the C&C traffic are significantly smaller than that of the background traffic. We present a method to calibrate the timing-based features of the simulated botnet traffic by estimating eligible RTT samples from the background traffic. We then salt C&C traffic, and design flow classifiers under four scenarios: with and without calibrating timing-based features of C&C traffic, without using timing-based features, and calibrating C&C traffic only in the test set. In the flow classifier, we strive to use features that are not readily susceptible to obfuscation or tampering such as port numbers or protocol-specific information in the payload header. We discuss the results for several supervised classifiers, evaluating botnet C&C traffic precision, recall, and overall classification accuracy. Our experiments reveal to what extent the presence of timing artifacts in botnet traces leads to changes in classifier results.
A large family of genes that share homology with CLAVATA3.

The receptor kinase superfamily in plants includes a large number of genes, but very little is known about the ligands that bind to these receptors. In the Arabidopsis genome, for example, 340 receptor kinase genes have been identified ([The Arabidopsis Genome Initiative, 2000][1]). The proteins
A robust speaker clustering algorithm

In this paper, we present a novel speaker segmentation and clustering algorithm. The algorithm automatically performs both speaker segmentation and clustering without any prior knowledge of the identities or the number of speakers. Our algorithm uses "standard" speech processing components and techniques such as HMM, agglomerative clustering, and the Bayesian information criterion. However, we have combined and modified these so as to produce an algorithm with the following advantages: no threshold adjustment requirements; no need for training/development data; and robustness to different data conditions. This paper also reports the performance of this algorithm on different datasets released by the USA National Institute of Standards and Technology (NIST) with different initial conditions and parameter settings. The consistently low speaker-diarization error rate clearly indicates the robustness and utility of the algorithm.
Xyloside-primed Chondroitin Sulfate/Dermatan Sulfate from Breast Carcinoma Cells with a Defined Disaccharide Composition Has Cytotoxic Effects in Vitro*

We previously reported that the xyloside 2-(6-hydroxynaphthyl) β-d-xylopyranoside (XylNapOH), in contrast to 2-naphthyl β-d-xylopyranoside (XylNap), specifically reduces tumor growth both in vitro and in vivo. Although there are indications that this could be mediated by the xyloside-primed glycosaminoglycans (GAGs) and that these differ in composition depending on xyloside and cell type, detailed knowledge regarding a structure-function relationship is lacking. In this study we isolated XylNapOH- and XylNap-primed GAGs from a breast carcinoma cell line, HCC70, and a breast fibroblast cell line, CCD-1095Sk, and demonstrated that both XylNapOH- and XylNap-primed chondroitin sulfate/dermatan sulfate GAGs derived from HCC70 cells had a cytotoxic effect on HCC70 cells and CCD-1095Sk cells. The cytotoxic effect appeared to be mediated by induction of apoptosis and was inhibited in a concentration-dependent manner by the XylNap-primed heparan sulfate GAGs. In contrast, neither the chondroitin sulfate/dermatan sulfate nor the heparan sulfate derived from CCD-1095Sk cells primed on XylNapOH or XylNap had any effect on the growth of HCC70 cells or CCD-105Sk cells. These observations were related to the disaccharide composition of the XylNapOH- and XylNap-primed GAGs, which differed between the two cell lines but was similar when the GAGs were derived from the same cell line. To our knowledge this is the first report on cytotoxic effects mediated by chondroitin sulfate/dermatan sulfate.
Brain regions and functional interactions supporting early word recognition in the face of input variability

Significance Since birth, infants begin to learn a myriad of sounds. Yet our knowledge of their abilities to remember specific sounds is primarily based on habituation studies that presented them with massive repetitions of single sounds. The present work opens vistas on the study of language acquisition and memory development by suggesting that the presence of various sounds during encoding does not impair recognition in newborns. Results also indicate that a coordinated interplay between temporal and frontal regions of the brain supports newborns’ ability to memorize specific words in this—previously thought—disruptive context. Perception and cognition in infants have been traditionally investigated using habituation paradigms, assuming that babies’ memories in laboratory contexts are best constructed after numerous repetitions of the very same stimulus in the absence of interference. A crucial, yet open, question regards how babies deal with stimuli experienced in a fashion similar to everyday learning situations—namely, in the presence of interfering stimuli. To address this question, we used functional near-infrared spectroscopy to test 40 healthy newborns on their ability to encode words presented in concomitance with other words. The results evidenced a habituation-like hemodynamic response during encoding in the left-frontal region, which was associated with a progressive decrement of the functional connections between this region and the left-temporal, right-temporal, and right-parietal regions. In a recognition test phase, a characteristic neural signature of recognition recruited first the right-frontal region and subsequently the right-parietal ones. Connections originating from the right-temporal regions to these areas emerged when newborns listened to the familiar word in the test phase. These findings suggest a neural specialization at birth characterized by the lateralization of memory functions: the interplay between temporal and left-frontal regions during encoding and between temporo-parietal and right-frontal regions during recognition of speech sounds. Most critically, the results show that newborns are capable of retaining the sound of specific words despite hearing other stimuli during encoding. Thus, habituation designs that include various items may be as effective for studying early memory as repeated presentation of a single word.
Supporting Serendipitous and Focused Search

People with complex information needs are for example Humanities researchers, who need advanced search engines to investigate their research questions. Much can be gained by combining research datasets, reusing tools and serendipitously discovering new insights for further research. Humanities researchers have different (large-scale) research datasets and tools, which are described differently with metadata. We present a highly interactive advanced search engine for Humanities researchers that semantically converges differently structured metadata records from different collections and institutions. It has features that support serendipitous and focused search in context based on the structure of the metadata used. This single system serves Humanities researchers by allowing them to search interactively across yet unexplored (research) data, discover patterns, locate relevant data for new insights, and find existing tools that could provide novel use cases.
Mothers' early depressive symptoms predict children's low social competence in first grade: mediation by children's social cognition.

BACKGROUND This study examined whether social-cognitive processes in children mediate relations between mothers' depressive symptoms across the first 3 years and children's first-grade social competence. Three maladaptive cognitions were examined: self-perceived social inadequacy, hostile attribution, and aggressive response generation. METHOD One thousand three hundred and sixty-four mothers reported depressive symptoms across early development, first-grade children reported target social cognitions, and children's first-grade social competence was observed and reported by multiple informants. RESULTS Findings demonstrated that (a) mothers' average depressive symptoms from 6 to 36 months predicted children's maladaptive social cognition in first grade, (b) low mother-child responsiveness mediated this relation, and (c) maladaptive social cognition mediated relations between mothers' early depressive symptoms and low first-grade social competence independent of later depressive symptoms. CONCLUSION When mothers' depressive symptoms occur early in development, they may set in motion low-responsive dyadic patterns that promote children's maladaptive social cognition and, as a result, low social competence.
Predicting aggressive behavior in children with the help of measures of implicit and explicit aggression

Aggressive behavior between children in schools is a topic that receives much interest as violence and aggressive behavior cause many maladaptive social outcomes in the school setting. In the current study the Implicit Association Test (IAT) was adapted as a measure of children’s implicit aggression, by assessing the association of the self category (vs. other) with the attribute concept of aggressive (vs. peaceful). In addition to the IAT, a questionnaire measure to assess explicit aggression was utilized. The main goal of the present contribution was to examine the predictive validity of measures of implicit as well as explicit aggression in predicting the scores in a competitive computer game as an indicator of children’s aggressive behavior. Taken together, the results indicated that measures of implicit and explicit aggression could serve as reliable predictors of children’s aggressive behavior and that the IAT possesses incremental validity in addition to the self-report measure.
Where is the voice of social work in the multi disciplinary palliative care team

In the medical world, audits are frequently conducted to assess performance ideals and generate better outcomes for staff and patients. Audits are not such a common measure in social work. In order to begin to find a place to articulate the value of social work within the work of Hospice, a snapshot survey was taken of referrals within Hospice programmes within a specified three month period. The results of the audit revealed some striking commonalities as well as variations which may reflect the communities the Hospices operate within. The results of four other audits taken within the social work literature are presented. Snapshot 'quotes' taken from international researchers set a foundation for social workers to articulate the value of their role within palliative care. It is argued that unless social workers begin to articulate the value of their skills, they are in danger of becoming a forgotten voice in the multi disciplinary team caring for the needs of Hospice patients and families.