Miracle-dz/UniFAR-FTUs huggingface dataset:
IN VITRO GROWTH OF THE BACTERIAL KIDNEY DISEASE ORGANISM RENIBACTERIUM SALMONINARUM ON A NONSERUM, NONCHARCOAL-BASED “HOMOSPECIES-METABOLITE” MEDIUM

Laboratory and field trials were conducted to evaluate in vitro growth of Renibacterium salmoninarum in media without serum or charcoal. Growth of this bacterium, the cause of bacterial kidney disease (BKD) in salmonids, is accelerated by addition of a growth enhancing “metabolite” of unknown composition to KDM2 medium, the medium commonly used for isolation of R. salmoninarum. KDM2 medium supplemented with greater than 1% (v/v) metabolite enhanced growth even without addition of either serum or charcoal. Medium containing 5% metabolite (denoted Five-M) allowed optimal growth in laboratory studies and was further evaluated as a primary plating medium for recovery of the bacterium isolated from chinook salmon (Oncorhynchus tshawytscha) exhibiting clinical BKD. Recovery rates of R. salmoninarum using Five-M medium were 4% and 36% higher, respectively, than comparable rates using a serum-based medium for the two salmon populations evaluated. Five-M medium is an effective, inexpensive alternative to serum-based or charcoal-based media.
Effects of F‐encoded components and F‐pilin domains on the synthesis and membrane insertion of TraA'‐'PhoA fusion proteins

F‐pilin, the 70‐amino‐acid F‐pilus subunit, accumulates in the cell envelope of F+strains in a process that requires interactions between its precursor (the traA gene product) and other host and F‐encoded proteins. Here, we have used a set of (traA‐phoA) genes to explore the effects of different TraA domains on the synthesis and membrane insertion of TraA‐PhoA fusion proteins, particularly in relation to other F‐encoded gene products. The 51‐amino‐acid TraA leader peptide fused directly to alkaline phosphatase was synthesized at comparable rates and incorporated rapidly and efficiently into the inner membrane in F' and F− cells. A second fusion gene encoded the TraA leader peptide and the first 51 amino acids of F‐pilin itself fused to PhoA (TraA'‐'PhoA‐102 polypeptide). Alkaline phosphatase activities and patterns of pulse‐labelled polypeptides indicated that TraA'‐'PhoA‐102 was synthesized at comparable rates in F' and F− cells, but in neither was the TraA'‐'PhoA‐102 polypeptide efficiently processed as a membrane protein. A third gene encoded the entire 121‐amino‐acid TraA polypeptide fused to PhoA (TraA‐'PhoA‐121 polypeptide). About 70% of the pulse‐labelled TraA‐'PhoA‐121 polypeptide was rapidly processed in F'cells, where it accumulated in the cell envelope as active alkaline phosphatase, whereas in F‐ cells, >5% of the pulse‐labelled polypeptide was processed. Additionally, the apparent rate of TraA‐'PhoA‐121 polypeptide synthesis was threefold higher in F'cells. The traQ gene alone could not substitute for F in restoring TraA‐'PhoA‐121 (or wild‐type F‐pilin) accumulation.
Dietary consumption of phytochemicals and breast cancer risk in Mexican women

Abstract Objective To perform an evaluation of selected phytochemicals intake and breast cancer (BC) risk in Mexican women. Design We conducted hospital-based case–control study. Setting Mexico City between 1994 and 1996. Subjects A total of 141 histologically confirmed BC cases were age-matched (±3 years) to an equal number of hospital controls. The reproductive history of each woman was obtained by direct interview. The dietary consumption of flavonols, flavones, flavan-3-ols, cinnamic acid, lariciresinol, pinoresinol, secoisolariciresinol, matairesinol and coumestrol was obtained by means of a validated FFQ. Results Among postmenopausal women, high dietary intake of flavonols and flavones was associated with a significant reduction of BC risk (high v. low tertile: OR = 0·21, 95 % CI 0·07, 0·60, P for trend = 0·004 and OR = 0·29, 95 % CI 0·10, 0·82, P for trend = 0·025, respectively); consumption of lignans (lariciresinol and pinoresinol) showed a similar effect, but only among premenopausal women (high v. low tertile: OR = 0·32, 95 % CI 0·10, 0·99, P for trend = 0·051 and OR = 0·19, 95 % CI 0·06, 0·62, P for trend = 0·006, respectively). Conclusions Our results support a protective role of specific dietary phytochemicals in BC risk by menopausal status, independent of other reproductive factors.
Longitudinal Clinicoelectrophysiologic Study of a Case of Lafora Disease Proven by Skin Biopsy

Summary A longitudinal clinicoelectrophysiologic study was undertaken of a 15‐year 2‐month‐old girl with Lafora disease who was diagnosed by skin biopsy and an immunohistochemical method with antisera against Lafora bodies. From age 10 years 5 months, 4 months after onset, EEG disclosed progressive deterioration of background activity and incremental increase in epileptic discharges. Photosensitivity was unique: Occipital spikes and diffuse spike‐wave discharges were provoked by low‐frequency repetitive photic stimuli but without elicitation of myoclonic seizures. Photosensitivity completely disappeared after age 13 years 10 months. High‐voltage somatosensory evoked potentials (SEPs) and high‐voltage flash visual evoked potentials (F‐VEPs) were seen before age 13. After age 13, progressive prolongation of I‐III and I‐V interpeak latencies of auditory brainstem responses (ABRs), progressive prolongation of latencies of photoevoked eyelid microvibrations, delayed latencies of pattern‐reversal visual evoked potentials, and a decrease in the V/I amplitude ratio of ABRs and the previously high F‐VEP amplitudes were observed.
Mining user check-in features for location classification in location-based social networks

With the increasing popularity of location-based social networks, a large number of users have been involved in the check-ins. The venues where the user frequently repeats check-ins tend to play a very important role in his daily life, as they not only dominate the user's mobility behavior but also imply the user's personal preferences. Therefore, fast discerning of such check-in venues could enable us to improve a wide range of location-based services. In this paper, we propose a new location classification problem for users of location-based social networks, in which we aim to discern, given the observation that a user makes a "new" check-in at a venue, whether he will frequently repeat check-ins at this venue. To solve the problem, we first extract 16 features attached to the user's "new" check-ins. With the publicly available check-in dataset, we then train a location classifier based on Support Vector Machine and compare it with two baselines based on majority voting. The comparison results demonstrate the practicability of the trained location classifier.
Pulmonary organs analysis method and its evaluation based on thoracic thin-section CT images

To diagnose the lung cancer as to determine if it has malignant or benign nature, it is important to understand the spatial relationship among the abnormal nodule and other pulmonary organs. But the lung field has very complicated structure, so it is difficult to understand the connectivity of the pulmonary organs using thin-section CT images. This method consists of two parts. The first is the classification of the pulmonary structure based on the anatomical information. The second is the quantitative analysis that is then applicable to differential diagnosis, such as differentiation of malignant or benign abnormal tissue.
Control of supramolecular rectangle self-assembly with a molecular template.

A facile method for controlling the self-assembly of supramolecular metallocycles on a highly oriented pyrolytic graphite (HOPG) surface is described. The process was demonstrated using 1,3,5-tris(10-carboxydecyloxy)benzene (TCDB), which self-assembles to form a stable monolayer with nanoscale cavities on HOPG, to template the deposition of supramolecular rectangles. Molecular distribution is controlled and monodispersion is achieved as the metallocycles self-organize into the cavities of the TCDB template.
Asymptomatic MERS-CoV Infection in Humans Possibly Linked to Infected Dromedaries Imported from Oman to United Arab Emirates, May 2015

In May 2015 in United Arab Emirates, asymptomatic Middle East respiratory syndrome coronavirus infection was identified through active case finding in 2 men with exposure to infected dromedaries. Epidemiologic and virologic findings suggested zoonotic transmission. Genetic sequences for viruses from the men and camels were similar to those for viruses recently detected in other countries.
Scalable Personalized Recommender System

Requirements and priorities for modern recommender systems grow and change hand in hand with the continuous growth of Internet users. In this paper we focus on aspects such as scalability, flexibility and speed of recommender systems, which nowadays play an important role. We propose novel hybrid recommender system, which utilizes user behaviour and context, items’ content and items' popularity and recency. We evaluate our approach in the domain of news articles, processing streaming data and computing recommendations online, in real-time. Conducted evaluations showed the benefits of using article trendiness as a strong component in the process of computing recommendations.
Summary Ribosomal protein L 24 defect in Belly spot and tail ( Bst ) , a mouse Minute

The Minutesare an intriguing group of eukaryotic mutations that have been valuable in elucidating concepts of cell autonomy, compartmental development and cell competition (Garcia-Bellido et al., 1973; Morata and Ripoll, 1975; Moreno et al., 2002; Stern and Tokunaga, 1971). First described in Drosophila melanogaster more than 80 years ago, this dominantly inherited class of mutants comprises over 50 loci scattered across the Drosophila genome (Lambertsson, 1998; Schultz, 1929). Despite the large degree of locus heterogeneity, Minutes are remarkably similar, sharing three principal phenotypes – a 2-3 day delay in larval development, short thin bristles and recessive lethality. Variable phenotypes include small body size, female sterility, large or rough eyes, and abnormal wings. The haploinsufficiency and nonadditivity of these mutations, and their phenotypic similarity, led Schultz (Schultz, 1929) to propose that each Minute represents a unique member of a common metabolic or biochemical pathway. This prescient prediction was confirmed, as all of the molecularly cloned Minute loci to date encode ribosomal proteins (Lambertsson, 1998). Although riboprotein mutations have also been identified in Escherichia coli and Saccharomyces cerevisiae (Warner, 1999), little is known about riboprotein mutations in mammals. The mammalian ribosome comprises 79 ribosomal proteins and four rRNAs, which combine in equimolar ratios to form the small (40S) and large (60S) subunits. Each riboprotein is encoded by a single gene. Despite the large number of riboprotein genes (Uechi et al., 2001), only one is known to be mutated in mammals. RPS19, a component of the small ribosomal subunit, is mutated in a quarter of humans with Diamond–Blackfan anemia (DBA, MIM205900), a congenital red blood cell hypoplasia (Draptchinskaia et al., 1999). In addition to anemia, these patients commonly have low birth weight, small stature, and craniofacial and skeletal defects. Aside from reduced somatic growth, it is unclear how these tissue-specific phenotypes result from mutations in a gene that is universally required for protein synthesis. Belly spot and tail ( Bst) is a semidominant, homozygous lethal mutation. Heterozygotes have decreased pigmentation and a kinked tail (Southard and Eicher, 1977). Bst/+ mice also have a significant retinal abnormality, characterized by delayed closure of the choroid fissure, marked deficiency of ganglion cells and subretinal neovascularization (Rice et al., 1995; Rice et al., 1997; Smith et al., 2000; Tang et al., 1999). Accordingly, Bst has been proposed as a model for human optic nerve atrophy and age-related macular degeneration. Here, we report that the riboprotein gene Rpl24 is mutated in Bst/+ mice. The mutation impairs Rpl24 mRNA splicing and L24 production, which in turn affects ribosome biogenesis, protein synthesis and the cell cycle. Bst/+ cells have a significant growth disadvantage in chimeras that is similar to the classical cell competition effect observed in Drosophila Minute somatic mosaics. These findings establish Bst as a mouse Minute.
A safety service manipulator system: the reduction of harmful force by a controllable torque limiter

Robots working in human environment for personal service should have both safety and dexterity function. Since these two functions have characteristics that influence each other on an implementation process, it is necessary to treat them together in a system. In this paper, we propose a safety serve manipulator system (SSM) which has the potential to realize both the safety and dexterity simultaneously, and discuss on the effectiveness of slip motion that is one of the safety functions of the SSM in reduction of contact force. The SSM slip motion is realized by torque limiters located on the base. We confirm the effectiveness of the torque limiters in reduction of harmful force at various limit torque and improve the reduction efficiency by controlling the limit torque. These are confirmed through simulations and experiments.
Association between the XRCC6 Promoter rs2267437 polymorphism and cancer risk: evidence based on the current literature.

BACKGROUND Increasing evidence suggests that the DNA repair gene XRCC6 (Ku70) may be critically involved in the aetiology of the human carcinogenesis. Many studies have investigated the association between the rs2267437 polymorphism and cancer susceptibility. However, the results of these studies have been controversial. This meta-analysis was conducted to quantitatively summarize the evidence for a relationship between the rs2267437 polymorphism and cancer risk. METHODS Electronic databases, including PUBMED and EMBASE, were searched for publications that met the inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between the XRCC6 promoter rs2267437 polymorphism and cancer risk in a fixed-effects model (the Mantel-Haenszel method) or a random-effects model (the DerSimonian and Laird method), as appropriate. RESULTS A total of 13 case-control studies, involving 3675 cases and 4247 controls, investigating the XRCC6 rs2267437 polymorphism and cancer susceptibility were identified for the meta-analysis. The pooled analysis showed that there is a significant relationship between the XRCC6 rs2267437 polymorphism and cancer susceptibility (GG vs. CC: OR=1.28, 95% CI=1.03-1.60). Subgroup analyses based on the cancer type, ethnicity, and source of the controls were also performed, and these results indicated that the XRCC6 promoter rs2267437 polymorphism was associated with cancer risk in breast cancer studies (GG vs. CC: OR=1.79, 95% CI=1.25-2.56; GG vs. CG+CC: OR=1.40, 95% CI=1.01-1.95), in Asian populations (GG vs. CC: OR=1.33, 95% CI=1.01-1.74) and in population-based studies (GG vs. CC: OR=1.57, 95% CI=1.12-2.22; CG vs. CC: OR=1.35, 95% CI=1.11-1.64; GG+CG vs. CC: OR=1.37, 95% CI=1.14-1.65). CONCLUSION This meta-analysis suggests that the XRCC6 rs2267437 polymorphism may affect breast cancer susceptibility and increase the risk of cancer in Asian populations and in the general population. It is critical that further large-scale and well-designed studies be conducted to confirm the association between the rs2267437 genotype and cancer risk.
Practical Fault Attack on a Cryptographic LSI with ISO/IEC 18033-3 Block Ciphers

This paper presents practical fault attack results on six kinds of block ciphers listed in ISO/IEC 18033-3 that are implemented on an LSI: AES, DES, Camellia, CAST-128, SEED, and MISTY1. We developed an experimental environment that injects faults into any desired round by supplying a clock signal with a glitch. We examined practical attack assumptions and the fault model based on experimental results. We also succeeded in recovering AES keys in the LSI using Piret's attack, which uses only one faulty cipher text obtained using the proposed experimental environment.
Implantable Cardioverter-Defibrillator Use and Benefit in Women

Women currently receive far fewer implantable cardioverter-defibrillators (ICDs) than do men. Some studies suggest bias in device utilization, with fewer women receiving ICDs despite a similar clinical profile. Other studies, however, describe differences in clinical presentation and arrhythmia risk. There may be autonomic and electrophysiological factors that suggest a lower susceptibility to arrhythmia in women. Although the data on the benefits of the ICD in women are limited by the low numbers of women enrolled in the landmark studies, most studies do suggest an efficacy in women similar to that in men. Further research is needed on the use of ICDs in women.
An Multi-Variant Relational Model for Money Laundering Identification using Time Series Data Set

-------------------------------------------------------ABSTRACT--------------------------------------------------Money laundering an unfair money transaction activity which threats the finance industries in higher rate. The illegal commercial peoples and terrorist, transfers huge amount into a single or many accounts, and it follows a big chain of accounts to reach the destination to which it has to be sent. Generally the financial banks enforce many restrictions to transfer amounts between accounts where they are done between internal or external accounts of the country. Identifying money laundering is a challenging task where the origin of transaction could not be identified easily when it follows a big chain or transferred as number of small amounts. There are methods discussed, which detects MI based on amount transferred and other factors. They suffer with the accuracy of MI detection and time complexity values. We propose a relational model which uses multiple factors and metrics to detect the money laundering. The proposed method uses time series data and identifies one-many and many-one relation between transactions to select vulnerable accounts. Identified vulnerable accounts and transactions of those accounts are split into different time frames and analyzed at each time frame to identify the presence of money laundering. The proposed method has produced higher accuracy in MI detection and has less time complexity which improves the performance of the method proposed.
Computation of monopole antenna currents using cylindrical harmonics

An eigenfunction expansion method is considered for computing the currents on a simple monopole antenna radiating into the half-space over an infinite perfect electric conductor ground plane. To apply the method, the monopole is enclosed by adding a second, parallel ground plane. The original half-space region is thus replaced by an infinite sequence of images. This approximation allows the fields to be represented using cylindrical harmonics expansions in each of two subregions between the ground planes. Coefficients of these expansions are found by enforcing E/sub z/=0 along the monopole surface as well as the continuity of the fields at the interface between the two subregions. Exhaustive computational checks were performed using the Numerical Electromagnetics Code as a benchmark. <<ETX>>
Suppression and restoration of cytotoxic T-cell activity during chemotherapy of a mouse T-cell lymphoma and a macrophage tumor.

Effects of therapy with antineoplastic chemicals on the growth of tumors and the induction of cytotoxic T-cells in the spleens of treated hosts were studied in mice bearing syngeneic tumors, J774 macrophage tumor or EL-4 T-cell lymphoma. Progressively growing tumors suppressed the capacity for in vitro inducibility of spleen T-cells cytotoxic to allogeneic target cells. Doses of nitrogen mustard, mitomycin C, and polyinosinic-polycytidylic acid, which decreased the growth of J774, counteracted the tumor-induced suppression of in vitro cytotoxic T-cell induction in spleen cells from BALB/c mice. Higher doses of nitrogen mustard and polyinosinic-polycytidylic acid inhibited the ability of spleen T-cells to become cytotoxic even in tumor-free mice. 1-β-d-Arabinofuranosylcytosine and nitrogen mustard decreased the growth of EL-4 ascites tumor and simultaneously restored the cytotoxic T-cell function of spleen cells in C57BL/6J mice. Polyinosinic-polycytidylic acid inhibited the growth of EL-4 only weakly and did not relieve the tumor-induced suppression of cytotoxic T-cell response. The highest levels of nitrogen mustard and polyinosinic-polycytidylic acid decreased cytotoxic T-cell activity in normal C57BL/6J mice. These results demonstrate the inhibitory effects of several chemotherapeutic drugs on tumor growth and simultaneously correlate with restoration of cell-mediated immunological reactivity.
Quantitative analysis of intonation patterns produced by Cantonese speakers with Parkinson's disease: a preliminary study

This preliminary study aimed to apply the command-response model to the analysis of disrupted intonation patterns in speakers with Parkinson’s disease (PD). Three Cantonese PD speakers with mild prosodic impairment participated. The speech stimuli were 36 utterances (questions and statements). Productions were analyzed using the model parameters (base frequency, magnitude and onset time of each phrase command, and amplitude and duration of each tone command). The results showed that Cantonese PD speakers marked the question-statement contrast only by adding a question boundary tone command and contrasting the duration of the tone command at the final position, but not by differences in base frequency, as previously reported for nondysarthric speakers. This study showed promising results for using the command-response model to analyze intonation patterns in Cantonese dysarthric speech. Additional modelling issues for this group of speakers are discussed.
Algorithm for formant tracking, modification and synthesis

During the production of voiced speech sounds thevocal folds vibrate in a quasi-periodic manner. The exci-tation signal produced by this oscillation is modulatedby the resonator system of the vocal tract (pharyngeal,nasal and oral cavity): while harmonics near the reso-nant frequency are boosted, other harmonics are at-tenuated. These vocal tract resonances are referred toas
A Novel Graph-Based Estimation of the Distribution Algorithm and its Extension Using Reinforcement Learning

In recent years, numerous studies have drawn the success of estimation of distribution algorithms (EDAs) to avoid the frequent breakage of building blocks of the conventional stochastic genetic operators-based evolutionary algorithms (EAs). In this paper, a novel graph-based EDA called probabilistic model building genetic network programming (PMBGNP) is proposed. Using the distinguished graph (network) structure of a graph-based EA called genetic network programming (GNP), PMBGNP ensures higher expression ability than the conventional EDAs to solve some specific problems. Furthermore, an extended algorithm called reinforced PMBGNP is proposed to combine PMBGNP and reinforcement learning to enhance the performance in terms of fitness values, search speed, and reliability. The proposed algorithms are applied to solve the problems of controlling the agents' behavior. Two problems are selected to demonstrate the effectiveness of the proposed algorithms, including the benchmark one, i.e., the Tileworld system, and a real mobile robot control.