Miracle-dz/UniFAR-FTUs huggingface dataset:
CELL LINE Establishment and characterization of a novel alveolar rhabdomyosarcoma cell line, NCC‑aRMS1‑C1

Alveolar rhabdomyosarcoma (aRMS) is a histological subtype of RMS, which is the most common pediatric and adolescent soft-tissue sarcoma, accounting for 3–4% of all pediatric malignancies. Patient-derived cells are essential tools for understanding the molecular mechanisms of poor prognosis and developing novel anti-cancer drugs. However, only a limited number of well-characterized cell lines for rhabdomyosarcoma from public cell banks is available. Therefore, we aimed to establish a novel cell line of aRMS from the tumor tissue of a patient with aRMS. The cell line was established from surgically resected tumor tissue from a 4-year-old male patient diagnosed with stage III, T2bN1M0 aRMS and was named as NCC-aRMS1-C1. The cells were maintained for more than 3 months under tissue culture conditions and passaged more than 20 times. We confirmed the presence of identical fusion gene such as PAX7-FOXO1 in both the original tumor and NCC-aRMS1-C1. The cells exhibited spheroid formation and invasion. We found that docetaxel, vincristine, ifosfamide, dacarbazine, and romidepsin showed remarkable growth-suppressive effects on the NCC-aRMS1-C1 cells. In conclusion, the NCC-aRMS1-C1 cell line exhibited characteristics that may correspond to the lymph node metastasis in aRMS and mirror its less aggressive features. Thus, it may be useful for innovative seeds for novel therapeutic strategies.
Ultrawideband Strip-Loaded Circular Slot Antenna With Improved Radiation Patterns

An ultrawideband strip-loaded circular slot antenna is proposed in this Communication, which presents a measured impedance bandwidth of 144.8% , much stable radiation patterns and small dimensions. The loading strip is used for redistributing the electric field within the slot to achieve stable radiation patterns across a wide frequency band, and it is optimized to influence on the impedance bandwidth as slightly as possible. For clarity, the simulated three-dimension (3-D) radiation patterns are given and compared with those of a conventional circular slot antenna without strip loading. The measured gain of the proposed antenna in the broadside direction is over 0 dBi from 2.4 to 11 GHz. The measured and simulated return losses and radiation patterns of the proposed antenna are given, and finally, parametric studies are performed for practical applications.
Reconsidering Linearity: Evidence from CV Metathesis

(1) S1 is consistent with the precedence structure of S2, and vice versa (No Metathesis). Let x, y ∈ S1 and x′, y′ ∈ S2. If x x′ and y y′, then x precedes (<) y iff x′ precedes (<) y′. • In other words, if a segment precedes another in the input, that precedence relation should be preserved by the corresponding segments in the output.3 • How many such relations exist in a word? • For a word of length n, there are (n2 − n)/2 pairs of segments with this precedence relation. • Example: The underlying form of hypothetical salofidu / / has eight segments, and 28 precedence relations.
Apoptosis induced by preoperative oral 5'-DFUR administration in gastric adenocarcinoma and its mechanism of action.

AIM To study the apoptosis induced by preoperative oral 5'-DFUR administration in gastric adenocarcinoma and its mechanism of action. METHODS Sixty gastric cancer patients were divided randomly into three groups (20 each group) before operation: group one:5'-DFUR oral administration at the dose of 800-1200 mg/d for 3 - 5 d, group two: 500 mg 5-FU + 200 mg/d CF by venous drip for 3 - 5 d,group three (control group). One or two days after chemotherapy, the patients were operated. Fas/FasL,PD-ECGF and PCNA were examined by immunohistochemistry and apoptotic tumor cells were detected by in situ TUNEL method. Fifty-four patients received gastrectomy, including 12 palliative resections and 42 radical resections. Six patients were excluded. Finally 18 cases in 5'-DFUR group, 16 cases in CF+5-FU group, and 20 cases in control group were analyzed. RESULTS There was no significant difference in patient mean age, gender, white blood cell count, haematoglobin (HB),thromboplastin, perioperative complication incidence, radical or palliation resection, invasion depth (T), lymphonode involvement (N),metastasis (M) and TNM staging among the three groups. However,the PCNA index (PI) in 5'-DFUR group (40.51+/-12.62) and 5-FU+CF group (41.12+/-15.26) was significantly lower than that in control group (58.33+/-15.69) (F=9.083, P=0.000). The apoptotic index (AI) in 5'-DFUR group (14.39+/-9.49) and 5-FU+CF group (14.11+/-9.68)was significantly higher than that in control group (6.88+/-7.37) (F=4.409, P=0.017). The expression rates of Fas and FasL in group one and group three were 66.7% (12/18) and 50% (9/18), 43.8% (7/16) and 81.3% (13/16), 45.0% (9/20) and 85% (17/20), respectively. The expression rate of FasL in 5'-DFUR group was significantly lower than that in the other two groups (chi2=6.708, P=0.035). Meanwhile, the expression rate of PD-ECGF was significantly lower in 5'-DFUR group (4/18,28.6%) than in CF+5-FU group(9/16,56.3%)and control group (13/20,65.0%) (chi2=7.542, P=0.023). The frequency of Fas expression was significantly correlated with palliative or radical resection (chi2=7.651, P=0.006), invasion depth (chi2=8.927, P=0.003), lymphatic spread (chi2=4.488, P=0.034) and UICC stages (chi2=8.063, P=0.045) respectively. By the end of March 2005,45 patients were followed up. The 0.5-, 1-, 2-, 3-year survival rates were 96%,73%,60%,48%, respectively, which were related with T, N, M and Fas expression, but not with PD-ECGF and FasL expression. CONCLUSION Preoperative oral 5'-DFUR administration may induce apoptosis of gastric carcinoma cells and decrease tumor cell proliferation index,but cannot improve the prognosis of patients with gastric cancer.Down-regulation of FasL and PD-ECGF expression mediated by 5'-DFUR may be one of its anti-cancer mechanisms.Fas expression correlates with the progression of gastric carcinoma and may be an effective prognostic factor.
The Costs and Cost-effectiveness of Collaborative Care for Adolescents With Depression in Primary Care Settings: A Randomized Clinical Trial.

Importance Depression is one of the most common adolescent chronic health conditions and can lead to increased health care use. Collaborative care models have been shown to be effective in improving adolescent depressive symptoms, but there are few data on the effect of such a model on costs. Objective To evaluate the costs and cost-effectiveness of a collaborative care model for treatment of adolescent major depressive disorder in primary care settings. Design, Setting, and Participants This randomized clinical trial was conducted between April 1, 2010, and April 30, 2013, at 9 primary care clinics in the Group Health system in Washington State. Participants were adolescents (age range, 13-17 years) with depression who participated in the Reaching Out to Adolescents in Distress (ROAD) collaborative care intervention trial. Interventions A 12-month collaborative care intervention included an initial in-person engagement session, delivery of evidence-based treatments, and regular follow-up by master's level clinicians. Youth in the usual care control condition received depression screening results and could access mental health services and obtain medications through Group Health. Main Outcomes and Measures Cost outcomes included intervention costs and per capita health plan costs, calculated from the payer perspective using administrative records. The primary effectiveness outcome was the difference in quality-adjusted life-years (QALYs) between groups from baseline to 12 months. The QALYs were calculated using Child Depression Rating Scale-Revised scores measured during the clinical trial. Cost and QALYs were used to calculate an incremental cost-effectiveness ratio. Results Of those screened, 105 youths met criteria for entry into the study, and 101 were randomized to the intervention (n = 50) and usual care (n = 51) groups. Overall health plan costs were not significantly different between the intervention ($5161; 95% CI, $3564-$7070) and usual care ($5752; 95% CI, $3814-$7952) groups. Intervention delivery cost an additional $1475 (95% CI, $1230-$1695) per person. The intervention group had a mean daily utility value of 0.78 (95% CI, 0.75-0.80) vs 0.73 (95% CI, 0.71-0.76) for the usual care group. The net mean difference in effectiveness was 0.04 (95% CI, 0.02-0.09) QALY at $883 above usual care. The mean incremental cost-effectiveness ratio was $18 239 (95% CI, dominant to $24 408) per QALY gained, with dominant indicating that the intervention resulted in both a net cost savings and a net increase in QALYs. Conclusions and Relevance Collaborative care for adolescent depression appears to be cost-effective, with 95% CIs far below the strictest willingness-to-pay thresholds. These findings support the use of collaborative care interventions to treat depression among adolescent youth. Trial Registration clinicaltrials.gov Identifier: NCT01140464.
The Small GTPase Arf6 Is Essential for the Tram/Trif Pathway in TLR4 Signaling*

Background: The small GTPase Arf6 affects LPS-induced cytokine secretion. Results: Arf6 regulates transport of the TLR4 adaptor protein Tram and internalization of LPS. Conclusion: Arf6 plays an essential role in regulating the Tram/Trif-dependent TLR4 pathway. Significance: Knowing how TLR4 is modulated is crucial for understanding innate immunity. Recognition of lipopolysaccharides (LPS) by Toll-like receptor 4 (TLR4) at the plasma membrane triggers NF-κB activation through recruitment of the adaptor proteins Mal and MyD88. Endocytosis of the activated TLR4 allows recruitment of the adaptors Tram and Trif, leading to activation of the transcription factor IRF3 and interferon production. The small GTPase ADP-ribosylation factor 6 (Arf6) was shown to regulate the plasma membrane association of Mal. Here we demonstrate that inhibition of Arf6 also markedly reduced LPS-induced cytokine production in Mal−/− mouse macrophages. In this article, we focus on a novel role for Arf6 in the MyD88-independent TLR4 pathway. MyD88-independent IRF3 activation and IRF3-dependent gene transcription were strictly dependent on Arf6. Arf6 was involved in transport of Tram to the endocytic recycling compartment and internalization of LPS, possibly explaining its requirement for LPS-induced IRF3 activation. Together, these results show a critical role for Arf6 in regulating Tram/Trif-dependent TLR4 signaling.
Performance Comparison of Cyclo-stationary Detectors with Matched Filter and Energy Detector

Cognitive Radio (CR) is a promising technology that can be used to alleviate the spectrum shortage problem or the barrier to communication in various application domains. CR has been proposed as a key solution for the problem of efficient usage of spectrum band. Spectrum sensing is one of the most important issues in cognitive radio system. Spectrum sensing involves in obtaining the usage characteristics across multiple dimensions such as time, space, frequency, code and what type of signal occupying the spectrum. In spectrum sensing, different method are proposed for identifying the presence of signal transmission all of which are in early development stage. They are Energy detection based spectrum sensing, Matched filter based and cyclostationary based spectrum sensing. This paper presents the calculation of probability of false alarm and probability detection verses SNR for three detectors, Comparison has been made in terms of receiver operating characteristic curves, Miss Detection probability Versus SNR and PSNR for three detectors.
Der Paradox-of-Choice-Effekt: Wenn individuelle Entscheidungsstile eine Auswahl ins Negative verkehren

KURZFASSUNG/ABSTRACT: Im okonomischen Kontext wird grosere Auswahl im Allgemeinen intuitiv bevorzugt. Diametral dazu postuliert das Paradox-of-Choice, dass extensive Sortimente negative Emotionen hervorrufen und Entscheidungen verhindern. Das Phanomen ist jedoch nicht konsistent und von vielerlei Antezedenzien determiniert. Ein allgemein gultiges Verstandnis zugrunde liegender Mechanismen ist nicht vorhanden. Diese Studie untersucht die Moderatoreigenschaften individuellen Entscheidungsverhaltens. Der Fokus liegt auf dem Ausmas kognitiver Anstrengungen, sowie konsumorientierter Entscheidungsstile. Mittels Online-Befragung wurden 482 verwertbare Datensatze generiert, ein Auftritt des Paradox-of-Choice wurde jedoch nicht belegt. Da multiple Faktoren und deren Wechselwirkungen beeinflussend wirken, ist dies keinesfalls als Falsifikation misszuverstehen. Vielmehr lasst die statistische Analyse nach wie vor einen Zusammenhang individueller Entscheidungsstrategien mit dem Paradox-of-Choice vermuten.
Non-volatile memories in FPGAs: Exploiting logic similarity to accelerate reconfiguration and increase programming cycles

Non-volatile memory (NVM) technologies have been known for their advantages of large capacity, low energy consumption, high error-resistance, and near-zero power-on delay. It is expected that they will replace traditional SRAM as FPGA reconfigurable blocks. While NVMs promise FPGAs with more reconfigurable resources, lower power consumption, and higher resilience to power interruptions, they also impose two new design challenges: the slow write performance of NVMs may degrade FPGA reconfiguration speed, while their limited write endurance constrains FPGA programming cycles. To overcome these challenges, we propose a similarity driven approach to reduce reconfiguration cost in NVM-based FPGAs. When synthesizing a new design, its similarity to the design currently on the FPGA is characterized by taking both LUT contents and CLB-level topology into consideration. The reconfiguration cost minimization problem is formulated as a bipartite graph matching problem and solved optimally. Experiments on standard circuit benchmarks show that the proposed algorithms eliminate more than 57.4% of NVM writes during the reconfiguration process, thus effectively improving performance and endurance of NVM-based FPGAs.
NUCLEOSIDE DIPHOSPHATASE AND THIAMINE PYROPHOSPHATASE ACTIVITIES IN THE ENDOPLASMIC RETICULUM AND GOLGI APPARATUS

The effects of pH, fixatives and divalent ions on nucleoside diphosphatase (NDPase) and thiamine pyrophosphatase (TPPase) activities in the endoplasmic reticulum (ER) and Golgi apparatus (GA) were examined in adult and neonatal hepatocytes and other cell types in the rat. In liver cells TPPase and NDPase both have a similar localization in the rough ER, nuclear envelope and smooth ER but differ in their pH optima; TPPase is most active at pH 8, NDPase at pH 7. TPPase in the GA, unlike its counterpart in the ER, is most active at neutral pH. High levels of NDPase activity are present in the GA of neurons, epididymis and other cells, but not in hepatocytes. TPPase in the ER, but not the GA, is stimulated by the addition of adenosine triphosphate to the medium. These observations show that different conditions are required to demonstrate ER and GA diphosphatase activities. Whether separate enzymes or multiple configurations of a single protein are responsible for these activities cannot be determined by staining procedures.
PERFORMANCE EVALUATION OF MEMORY BASED CLASSIFIERS WITH CORRELATION BASED FEATURE SELECTION SUBSET EVALUATOR FOR SMART HEART DISEASE PREDICTION

Healthcare industries collect voluminous clinical data which are not able to process manually. Advancements in Technology played a vital role in storing and processing such huge collection of clinical data. Medical decision support systems are intended to support doctors in their diagnosis. This provides effort to widen knowledge and understanding of frequent specialists and facilitates the diagnosis process, using patients’ data from clinical databases. Identification of heart disease is a momentous and difficult task in medicine. It is crucial to find the best fit classification algorithm that has greater accuracy on classification in heart disease prediction. This research work compares the competence of Memory based classifiers for prediction of heart diseases by taking several measures using open access machine learning tool.
Success Rates for Functional MR Imaging in Children

BACKGROUND AND PURPOSE: Functional MR imaging is widely used for research in functional brain development in healthy children. However, obtaining high-quality brain imaging data from pediatric research participants requires cooperation that is challenging for young children. In this study, we examined success rates for fMRI in typically developing children in both longitudinal and cross-sectional research study designs to inform the recruitment needs of future pediatric brain imaging studies. MATERIALS AND METHODS: In the cross-sectional study, 459 healthy children (5–18 years of age, 215 girls) were recruited. A subset of 30 healthy children 5–7 years of age from the cross-sectional cohort were selected and scanned for 10 consecutive years in the longitudinal arm of the study. Following anatomic scans, each participant attempted 4 functional MR imaging tasks. Success rate was defined as the proportion of fMRI tasks completed. Differences in success rates across sexes and in cross-sectional-versus-longitudinal cohorts were evaluated by using the Fischer exact test. RESULTS: In the cross-sectional study, 74% of the children completed all tasks. Success rates for individual tasks ranged from 34% to 67% for children 5–7 years of age and 76%–100% for those 8–18 years of age. In the longitudinal study, 89% of children completed all tasks in all 10 years. We established significance (P < .0001) between the cross-sectional and longitudinal cohorts for both 0% and 100% task completion rates. There was no significance between sexes. CONCLUSIONS: When designing pediatric fMRI studies in children, the sample sizes indicated by power analysis should be scaled up according to age (ie, 33% for ages 8–18 years, 50% for ages 5–7 years).
Nonlinear speed estimation of a GPS-free UAV

In this article, the problem of robust state observer design for a class of unmanned aerial vehicles (UAVs) is addressed. A prototype four-rotors helicopter robot for indoors and outdoors applications is considered: the drone is not equipped with GPS related devices, so we describe a strategy to estimate its translational velocity vector based on acceleration, angles and angular speeds measurements only. Since the linearised system is non-observable at the equilibrium point, a nonlinear observability verification is performed for persistently exciting trajectories. A global exponential solution to this open problem is provided in the framework of adaptive observation theory when exact measurements are available. A modified observer is presented to enhance velocity estimation robustness in the realistic case of noisy measurements. The results are compared with a classical estimation strategy based on the extended Kalman filter to test the algorithm's performance.
Improving the quality of randomized controlled trials in Chinese herbal medicine, part IV: applying a revised CONSORT checklist to measure reporting quality.

OBJECTIVE To discuss the quality of reporting in randomized controlled trials (RCTs) of Chinese herbal medicine (CHM), and to provide suggestions for improving the reporting of future clinical studies in this therapeutic area. METHODS A search of the Cochrane Library was conducted to identify RCTs of CHM. A revised CONSORT checklist designed for CHM clinical studies was implemented. The revised CONSORT checklist contained 63 items, including the following new items added specifically for CHM: (1) "syndrome of disease" based on Chinese medicine theories; (2) rationale of CHM formula; (3) formula composition; (4) preparation form of CHM; (5) quality control of CHM. RESULTS The overall reporting quality of the RCTs as assessed with the revised CONSORT checklist varied between 19% and 44%, with a median score of 32% (standard deviation 8%). CONCLUSION The overall quality of reporting of RCTs of CHM evaluated with a revised CONSORT checklist was poor, reflecting the need for improvements in reporting future clinical trials in this area. RECOMMENDATIONS To improve the quality of reporting of RCTs of CHM, we recommend adopting a revised CONSORT checklist that includes items specific to CHM. We also recommend that editors of CHM journals require authors to use a structured approach to presenting their trials as a condition of publication.
The distance discordance metric—a novel approach to quantifying spatial uncertainties in intra- and inter-patient deformable image registration

Previous methods to estimate the inherent accuracy of deformable image registration (DIR) have typically been performed relative to a known ground truth, such as tracking of anatomic landmarks or known deformations in a physical or virtual phantom. In this study, we propose a new approach to estimate the spatial geometric uncertainty of DIR using statistical sampling techniques that can be applied to the resulting deformation vector fields (DVFs) for a given registration. The proposed DIR performance metric, the distance discordance metric (DDM), is based on the variability in the distance between corresponding voxels from different images, which are co-registered to the same voxel at location (X) in an arbitrarily chosen ‘reference’ image. The DDM value, at location (X) in the reference image, represents the mean dispersion between voxels, when these images are registered to other images in the image set. The method requires at least four registered images to estimate the uncertainty of the DIRs, both for inter- and intra-patient DIR. To validate the proposed method, we generated an image set by deforming a software phantom with known DVFs. The registration error was computed at each voxel in the ‘reference’ phantom and then compared to DDM, inverse consistency error (ICE), and transitivity error (TE) over the entire phantom. The DDM showed a higher Pearson correlation (Rp) with the actual error (Rp ranged from 0.6 to 0.9) in comparison with ICE and TE (Rp ranged from 0.2 to 0.8). In the resulting spatial DDM map, regions with distinct intensity gradients had a lower discordance and therefore, less variability relative to regions with uniform intensity. Subsequently, we applied DDM for intra-patient DIR in an image set of ten longitudinal computed tomography (CT) scans of one prostate cancer patient and for inter-patient DIR in an image set of ten planning CT scans of different head and neck cancer patients. For both intra- and inter-patient DIR, the spatial DDM map showed large variation over the volume of interest (the pelvis for the prostate patient and the head for the head and neck patients). The highest discordance was observed in the soft tissues, such as the brain, bladder, and rectum, due to higher variability in the registration. The smallest DDM values were observed in the bony structures in the pelvis and the base of the skull. The proposed metric, DDM, provides a quantitative tool to evaluate the performance of DIR when a set of images is available. Therefore, DDM can be used to estimate and visualize the uncertainty of intra- and/or inter-patient DIR based on the variability of the registration rather than the absolute registration error.