Miracle-dz/UniFAR-FTUs huggingface dataset:
The GBFM radar mosaic of the Eurasian Taiga: selected topics on geo-location and preliminary thematic products

In the context of the Global Boreal Forest Mapping project (GBFM), an initiative of the Japan Aerospace Exploration Agency (JAXA), a continental scale radar mosaic of the Eurasian Taiga was compiled. The mosaic is composed of some 520 strip-images (typically covering 80 km by 2500 km each) acquired in 1997-98 by the L-band SAR aboard the JERS-1 spacecraft. The mosaic was assembled in two phases. Coverage in the first stage included the area between the Ural Mountains in the west, Bering Strait in the east, Arctic Ocean in the north and the Korean Peninsula in the south. In the second phase an extended version was produced that comprises the European part of the Boreal ecosystems west of the Ural Mountain and up to the European Union region. Pixel spacing of the high resolution final products is 100 m and map projection is Albers equal-area conical. In this paper selected topics are presented related to a revision of the mosaic geometry. This step was called for to improve the internal consistency and assure proper absolute geo-location of the mosaics with respect to reference data sets. It consists of: i) a data representation (virtual frames) for handling the strip-images in smaller units that are more effective for dealing with local distortions; and ii) inclusion of control points derived from the Landsat GeoCover data sets. Results characterizing the mosaic geometric accuracy in terms of root mean square residuals are reported. Finally, we present, as a first thematic result, a vegetation map at coarse resolution (900 m) derived by a combination of the Global Land Cover 2000 map and the GBFM radar mosaic
Intricate Regulation of Tyrosine Hydroxylase Activity and Gene Expression

Abstract: Tyrosine hydroxylase catalyzes the rate‐limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine. Therefore, the regulation of tyrosine hydroxylase enzyme number and intrinsic enzyme activity represents the central means for controlling the synthesis of these important biogenic amines. An intricate scheme has evolved whereby tyrosine hydroxylase activity is modulated by nearly every documented form of regulation. Beginning with the genomic DNA, evidence exists for the transcriptional regulation of tyrosine hydroxylase mRNA levels, alternative RNA processing, and the regulation of RNA stability. There is also experimental support for the role of both translational control and enzyme stability in establishing steady‐state levels of active tyrosine hydroxylase protein. Finally, mechanisms have been proposed for feedback inhibition of the enzyme by catecholamine products, allosteric modulation of enzyme activity, and phosphorylation‐dependent activation of the enzyme by various different kinase systems. Given the growing literature suggesting that different tissues regulate tyrosine hydroxylase mRNA levels and activity in different ways, regulatory mechanisms provide not only redundancy but also diversity in the control of catecholamine biosynthesis.
Predictive Biomarkers and Personalized Medicine TP 53 GenomicStatusRegulates Sensitivity of GastricCancer Cells to the HistoneMethylation Inhibitor 3-Deazaneplanocin A ( DZNep )

Purpose: DZNep (3-deazaneplanocin A) depletes EZH2, a critical component of polycomb repressive complex 2 (PRC2), which is frequently deregulated in cancer. Despite exhibiting promising anticancer activity, the specific genetic determinants underlying DZNep responsiveness in cancer cells remain largely unknown. We sought to determine molecular factors influencing DZNep response in gastric cancer. Experimental Design: Phenotypic effects of DZNep were evaluated in a panel of gastric cancer cell lines. Sensitive lines were molecularly interrogated to identify potential predictors of DZNep responsiveness. The functional importance of candidate predictors was evaluated using short hairpin RNA (shRNA) and siRNA
Anomaly Detection in Business Process Runtime Behavior - Challenges and Limitations

Anomaly detection is generally acknowledged as an important problem that has already drawn attention to various domains and research areas, such as, network security. For such "classic" application domains a wide range of surveys and literature reviews exist already - which is not the case for the process domain. Hence, this systematic literature review strives to provide an organized holistic view on research related to business process runtime behavior anomaly detection. For this the unique challenges of the process domain are outlined along with the nature of the analyzed data and data sources. Moreover, existing work is identified and categorized based on the underlying fundamental technology applied by each work. Furthermore, this work describes advantages and disadvantages of each identified approach. Based on these information limitations and gaps in existing research are identified and recommendations are proposed to tackle them. This work aims to foster the understanding and development of the process anomaly detection domain.
A presentation of the REPERE challenge

The REPERE Challenge aims to support research on people recognition in multimodal conditions. To assess the technology progress, annual evaluation campaigns will be organized from 2012 to 2014. In this context the REPERE corpus, a French video corpus with multimodal annotation, has been developed. The systems have to answer the following questions: Who is speaking? Who is present in the video? What names are cited? What names are displayed? The challenge is to combine the various information coming from the speech and the images.
Tests for mean vectors in high dimension

Traditional multivariate tests, Hotelling's \documentclass{article}\usepackage{amsmath}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{amsfonts}\pagestyle{empty}\begin{document}$T^2$ \end{document} or Wilks \documentclass{article}\usepackage{amsmath}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{amsfonts}\pagestyle{empty}\begin{document}$\Lambda$ \end{document}, are designed for a test of the mean vector under the condition that the number of observations is larger than the number of variables. For high‐dimensional data, where the number of features is nearly as large as or larger than the number of observations, the existing tests do not provide a satisfactory solution because of the singularity of the estimated covariance matrix. In this article, we consider a test for the mean vector of independent and identically distributed multivariate normal random vectors where the dimension is larger than or equal to the number of observations. To solve this problem, we propose a modified Hotelling statistic. Simulation results show that the proposed test is superior to other tests available in the literature. However, because we do not know the theoretical distribution of this modified statistic, Monte Carlo methods were used to reach this conclusion. Instead of using conventional Monte Carlo methods, which perform a fixed‐number of simulations, we suggest using the sequential Monte Carlo test in order to decrease the number of simulations needed to reach a decision. Simulation results show that the sequential Monte Carlo test is preferable to a fixed‐sample test, especially when using computationally intensive statistical methods. © 2013 Wiley Periodicals, Inc. Statistical Analysis and Data Mining, 2013
A dynamic load balancing policy with a central job dispatcher (LBC)

A dynamic load balancing policy with a central job dispatcher, called the LBC policy, is proposed for distributed systems. The design of this policy is motivated by the operation of a single-queue-multi-server queuing system. The average job response time of this policy is the same as that of a single-queue-multi-server system which is the best achievable performance when the communication delay is reduced to zero. Hence, this policy is expected to provide near minimum average job response time for distributed systems with high-speed communication subnets. The performance of this policy is studied for systems with non-negligible job transfer delays in the following three aspects: average job response time, overhead due to information exchanges, and sensitivity to heterogeneous load. <<ETX>>
Functional self-association of von Willebrand factor during platelet adhesion under flow

We have used recombinant wild-type human von Willebrand factor (VWF) and deletion mutants lacking the A1 and A3 domains, as well as specific function-blocking monoclonal antibodies, to demonstrate a functionally relevant self-association at the interface of soluble and surface-bound VWF. Platelets perfused at the wall shear rate of 1,500 s−1 over immobilized VWF lacking A1 domain function failed to become tethered to the surface when they were in a plasma-free suspension with erythrocytes, but adhered promptly if soluble VWF with functional A1 domain was added to the cells. The same results were observed when VWF was immobilized onto collagen through its A3 domain and soluble VWF with deleted A3 domain was added to the cells. Thus, VWF bound to glass or collagen sustains a process of homotypic self-association with soluble VWF multimers that, as a result, can mediate platelet adhesion. The latter finding demonstrates that direct immobilization on a substrate is not a strict requirement for VWF binding to platelet glycoprotein Ibα. The dynamic and reversible interaction of surface-bound and soluble VWF appears to be specifically homotypic, because immobilized BSA, human fibrinogen, and fibronectin cannot substitute for VWF in the process. Our findings highlight a newly recognized role of circulating VWF in the initiation of platelet adhesion. The self-assembly of VWF multimers on an injured vascular surface may provide a relevant contribution to the arrest of flowing platelets opposing hemodynamic forces, thus facilitating subsequent thrombus growth.
Control of and experimentation on an active dual-mode twisted string actuation mechanism

In this paper, we present the control of and experimentation on an active dual-mode twisted string actuation mechanism for automatic transmission. This mechanism has a two-stage transmission ratio and is implemented by changing the twisted radius of the string in each mode (force mode or speed mode). Control algorithms for implementing different transmission ratios are proposed and experimentally verified. Moreover, this mechanism was able to change its compliance characteristics depending on the mode and it was also experimentally confirmed by impulse testing. Since this is a compact and simple transmission mechanism, it can be simply applied to small robotic system and provide a wide operating range and variable compliance.
An Evaluation of Ketostix Strips

The usefulness of Ketostix as a semiquantitative screening procedure for the estimation of acetoacetate concentration in both plasma and urine has been established. Because of the reasonably constant relationship of β-hydroxybutyrate to acetoacetate, Ketostix also gives a good indication of the (β-hydroxybutyrate concentration. By reading the Ketostix after thirty seconds instead of the recommended fifteen seconds, the sensitivity of the reaction is increased. The use of Ketostix to examine the plasma from patients with diabetic acidosis will reliably distinguish ketotic from nonketotic cases and is strongly recommended for this purpose.
A/B testing: A promising tool for customer value evaluation

This paper aims to describe the use of A/B testing, a method used in web-development and position it in the context of the requirements engineering process and customer value evaluation. We propose that A/B testing can complement qualitative user research and offer a potential way to validate the value which system improvements bring to customers. Finally, we discuss our research plan for investigating the use of A/B testing in company contexts.
An InP-Based Monolithically Integrated Reconfigurable Optical Add–Drop Multiplexer

We demonstrate an InP-based monolithically integrated reconfigurable optical add-drop multiplexer consisting of an array waveguide grating, a semiconductor optical amplifier, four 2x2 Mach-Zehnder optical switches, and four PIN photodetectors using the asymmetric twin waveguide technology. The total chip size is 10 x 6 mm, and each of the components in the circuit exhibited performance similar to that achieved in a discrete form. The add-drop functionality of the chip is demonstrated via the routing of the signal from the add port to the drop/output port.
Connectivity guarantee during wireless sensor networks deployment

In this paper, we consider the self-deployment of wireless sensor networks. We present a mechanism which allows to preserve network connectivity during the deployment of mobile wireless sensors. Our algorithm is distributed and is based on a subset of neighbours for motion decision. Our algorithm maintains a connected topology regardless of the direction chosen by each sensor. To preserve connectivity, the distance covered by the mobile nodes is constrained by the connectivity of the node to its neighbours in a connected subgraph like the relative neighbourhood graph (RNG). We show the connectivity preservation property of our algorithm through analysis and present some simulation results for the full coverage problem.
Formal Characteristics of Thematic Apperception Test Narratives of Adult Patients with an Autism Spectrum Disorder. A Preliminary Study

This study explored the usefulness of a Thematic Apperception Test (TAT, Murray, 1943) narrative scoring system to detect signs of autistic information processing. A total of 27 patients with an Autism Spectrum Disor- der were compared to a control group (N = 67) of patients with other psychiatric disorders. As an external indi- rect measure of social functioning two dimensions of the Social Cognition and Object Relation Scale (SCORS; Westen,1985) were used: Capacity for Emotional and Moral Investment in Relationships and Understanding of Social Causality. TAT narratives were rated on the prevalence of eight phenomena, as proposed by Edrisi and Eurelings-Bontekoe (2009). Autistic patients showed a lower level of social insight and were particularly char- acterized by high scores on Weak Central Coherence, Jumping to Conclusions and Difficulty with describing/ interpreting movements. Results provide preliminary support for the usefulness of the TAT scoring system, but need to be replicated using larger samples and blind scoring.
Three-Dimensional Chemical Structure Search Using the Conformational Code for Organic Molecules (CCOM) Program.

Searching the 3D structural fragments of organic molecules is challenging because of structural differences between X-ray and theoretically calculated geometries and the conformational flexibility of substituents. The codification program called Conformational Code for Organic Molecules (CCOM) can be used to unambiguously convert 3D conformational data for various molecules to 1D data. Two deviations from Rule E-5.6 of the International Union of Pure and Applied Chemistry (IUPAC) Rules for Nomenclature of Organic Chemistry were introduced to the CCOM program for 3D fragment searching. First, the search for the highest priority atom was limited to a distance of two bonds from the center bond for dihedral angle determination. Second, for indistinguishable atoms in experimentally observed solution structures, the smallest number of atom index in the molecular model was chosen as the priority atom for dihedral angle determination. A search of the 3D conformational fragment mb_3a6c4c of mevastatin () in combination with the SMiles ARbitrary Target Specification (SMARTS) description suggested that a change in the conformation of this fragment may be the driving force for dissociation of mevastatin from its target protein. Chirality 28:370-375, 2016. © 2016 Wiley Periodicals, Inc.
Short-term statin administration in hypercholesterolaemic rabbits resistant to postconditioning: effects on infarct size, endothelial nitric oxide synthase, and nitro-oxidative stress.

AIMS The effectiveness of postconditioning (POC) in hypercholesterolaemia is in dispute. We investigated the effects of 3-day lipophilc (simvastatin) or hydrophilic (pravastatin) statin treatment, without or with POC in normocholesterolaemic (Norm) and hypercholesterolaemic (Chol) rabbits. METHODS AND RESULTS Norm or Chol rabbits were subjected to 30 min ischaemia and randomized in two series of 12 groups each: control, simvastatin (Sim), pravastatin (Prav), POC, Sim-POC, Prav-POC, Chol, Sim-Chol, Prav-Chol, POC-Chol, Sim-POC-Chol, Prav-POC-Chol. After ischaemia, rabbits of the first series underwent 3 h reperfusion, followed by infarct size, total cholesterol, and low density lipoprotein plasma level evaluation; animals of the second series underwent 10 min reperfusion followed by tissue sampling for nitrotyrosine (NT), malondialdehyde, endothelial nitric oxide synthase (eNOS), and Akt analyses. N-nitro-l-arginine methylester (L-NAME) was given in two additional groups (POC-L-NAME and Prav-Chol-L-NAME) for infarct size assessment. All interventions reduced infarction in Norm (24.3 ± 1.3, 25.9 ± 2.8, 27.9 ± 3.1, 23.3 ± 2.3, and 33.4 ± 2.5%, in POC, Sim, Prav, Sim-POC, and Prav-POC groups, respectively, vs. 49.3 ± 1.9% in control, P < 0.05), but only Prav did so in Chol animals (25.7 ± 3.3 and 25.3 ± 3.9% in Prav-Chol and Prav-POC-Chol vs. 50.9 ± 1.7, 44.8 ± 4.3, 41.5 ± 3.5, and 49.3 ± 5.5% in Chol, Sim-Chol, POC-Chol, and Sim-POC-Chol, respectively, P < 0.05). L-NAME abolished the infarct size-limiting effect of POC and Prav-Chol. Prav induced the greatest reduction in NT, while it was the only intervention that increased myocardial eNOS and Akt in Chol rabbits (P < 0.05 vs. all others). CONCLUSION Prav, in contrast to same-dose Sim or POC, reduces infarction in Chol rabbits independently of lipid lowering, potentially through eNOS activation and nitro-oxidative stress attenuation.
cis-Bis(azido-κN)bis(pyridine-2-carboxamide-κ2 N 1,O)nickel(II)

The title compound, [Ni(N3)2(C6H6N2O)2], was obtained as the first crystalline product from the reaction of Ni(NO3)2·6H2O, picolinamide and NaN3 in aqueous media. After a few days in the mother liquor, crystals of the cis isomer transformed into the trans isomer [Đaković & Popović (2007 ▶). Acta Cryst. C63, m507–m509]. The Ni atom exhibits a distorted octahedral environment and contains two azide ions and two planar N,O-chelating picolinamide ligands, all cis related. The dihedral angle between the two chelate rings is 82.43 (7)°. Pairs of molecules are linked by N—H⋯N hydrogen bonds into cyclic R 2 2(16) dimers, which are further packed into a three-dimensional framework by C(6) and C(8) chains by N—H⋯N hydrogen bonds.
Amelioration of High-Fat Feeding–Induced Insulin Resistance in Skeletal Muscle With the Antiglucocorticoid RU486

Fat feeding produces whole-body insulin resistance and decreased glucose uptake in muscle tissue of rats. To examine the effect of glucocorticoid blockade on the insulin resistance caused by high-fat feeding, four groups of rats were fed diets high in starch (70% of calories) or fat (59% of calories) for 4 weeks with or without the antiglucocorticoid RU486 (69.8 μmol · kg−1 · day−1) in the food. Whole-body insulin action was assessed by the euglycemic clamp technique at an upper physiological insulin level with bolus 2-[3H]deoxyglucose to determine individual tissue insulin-stimulated glucose uptake. Whole-body glucose utilization (clamp glucose infusion rate [GIR]) was decreased by high-fat feeding (GIR 68.3 ± 12.2 vs. 182.6 ± 12.8 μmol · kg−1 · min−1 for the starch-fed group; P < 0.001). Addition of RU486 to the diet significantly improved (GIR 133.9 ± 12.8 μmol · kg−1 · min−1; P < 0.01), but did not fully reverse, the insulin resistance caused by fat feeding. RU486 was without effect in the starch-fed rats. In skeletal muscles, RU486 ameliorated 62 and 68% of the insulin resistance produced by fat feeding in red quadriceps and extensor digitorum longus hindlimb muscles, respectively, but had no effect in heart or white adipose tissue. These results suggest that glucocorticoids play, in a tissue-specific manner, a role in the maintenance and/or production of insulin resistance produced by high-fat feeding.
La marque comme levier de tangibilisation des services

L’intangibilite a ete reconnue comme etant la caracteristique la plus importante parmi celles qui differencient un service d’un produit (p.ex., Zeithaml et Bitner, 2000 ; Bebko, 2000 ; Rushton et Carson, 1989 ; Flipo, 1988). Elle fait reference d’une part a l’impossibilite de voir, de toucher, de sentir, ou encore d’essayer le service avant de l’acheter (p.ex., Shostack, 1977 ; Flipo, 1988 ; Kurtz et Clow, 1998 ; Zeithaml et Bitner, 2000), et d’autre part a la difficulte de saisir mentalement le service (Bateson, 1979 ; Rushton et Carson, 1989 ; McDougall et Snetsinger, 1990) L’intangibilite des services a des consequences importantes a la fois pour le consommateur et pour le prestataire de service. Le plus souvent, ces consequences sont dommageables. Ainsi par exemple, du a son caractere intangible, le service est beaucoup plus difficile a apprehender (p.ex. Rushton et Carson, 1989) et a evaluer par le consommateur (p.ex. Levitt, 1981), ce qui augmente son incertitude et son risque percu. De meme, il est plus complexe pour le prestataire de communiquer autour de l’offre de service (Rust, Zahorik, Keiningham, 1996). De plus, le prestataire de service controle plus difficilement la qualite du service (Bebko, 2000), et la fixation du prix est plus delicate. Face a ces principales consequences, la litterature sur les services est unanime : il est imperatif de tangibiliser le service pour permettre aux consommateurs de mieux le saisir, de mieux le comprendre et d’etre ainsi rassures (Flipo, 1988). La litterature offre plusieurs pistes ou techniques pour tangibiliser le service, principalement par la mise en place d’indices peripheriques tangibles dans l’offre de service. Mais curieusement, peu - voire pas - d’etudes ont evalue la capacite de la marque a contribuer a tangibiliser le service. Nous presentons des lors une piste de recherche innovante qui cherche a evaluer si le developpement et la gestion d’une marque de service forte peut contribuer a la tangibilisation du service sur une ou plusieurs de ses dimensions.
Privacy preserving in data-mining : A survey on security of outsourced transaction databases

Database Outsourcing is a promising data management system in which Data-owner stores the confidential information at the third party service provider‟s site. The service provider manages and administers the database and avails the readymade services to the data owner and their clients to create, update, delete and access the database. Although database security is required because more service providers are not trustworthiness.The major requirements for getting security in outsourced databases are confidentiality, privacy, integrity, freshness in case of dynamic updates, access control in multi-user environment, availability and query authentication and assurance. To achieve these all requirements various security mechanisms like access control based approach, order preserving encryption based approach, hardware based encryption approach, fake tuple based approach, secret sharing approach, authenticated data structure approach, attributes based approach, combined fragmentation and encryption based approach, have been put forth till date. In this paper various security mechanisms analyzed and their significance given in this survey paper.