Miracle-dz/UniFAR-FTUs huggingface dataset:
Fast Specimen Boundary Tracking and Local Imaging with Scanning Probe Microscopy

An efficient and adaptive boundary tracking method is developed to confine area of interest for high-efficiency local scanning. By using a boundary point determination criterion, the scanning tip is steered with a sinusoidal waveform while estimating azimuth angle and radius ratio of each boundary point to accurately track the boundary of targets. A local scan region and path are subsequently planned based on the prior knowledge of boundary tracking to reduce the scan time. Boundary tracking and local scanning methods have great potential not only for fast dimension measurement but also for sample surface topography and physical characterization, with only scanning region of interest. The performance of the proposed methods was verified by using the alternate current mode scanning ion-conductance microscopy, tapping, and PeakForce modulation atomic force microscopy. Experimental results of single/multitarget boundary tracking and local scanning of target structures with complex boundaries demonstrate the flexibility and validity of the proposed method.
Design and Characterization of New Nano System for Delivery of Erythropoietin

Erythropoietin (EPO) can increase cell maintenance during different damages of central nervous system as a strong cell protector. However, studies displayed that brain-blood barrier prevents the entrance of large proteins similar to EPO (30.4kD) into the brain. The goal of this study was to find an alternative method for delivering of EPO to the brain to skip the blood brain barrier using design of new nanodrug delivery system. Then, anew cationic Gemini surfactant has been used in this study for preparation of EPO-loaded Gemini micelles. The physic chemical properties of nano micelles was investigated using Dynamic light scattering (DLS) and ζ-potential measurement, Morphology studies and in vitro drug release. Preparation of EPO loaded Gemini micelles results indicate that there are appropriate interactions between EPO drug and Gemini micelles and that of the EPO loaded in to the Gemini nanoparticles. DLS results display that size of the Gemini-EPO nanoparticle is smaller than 150 nm. Morphology studies results have further shown that, micelles (EPO-loaded) having smooth regular surface and the sizes of TEM micrograph were reported between 100-150 nm. Also, in vitro drug release results indicate that nanomicells (EPO-loaded) has been degraded in simulated early-time periods and released the drug into a simulated solution results also indicate decreasing stability structure of EPO-Gemini against temperature. In conclusion, the obtained results proposed that Gemini as a Nano carrier can bind to EPO with smooth surface micelles and size of 114 nm and can be considered as a candidate for drug delivery (EPO).
Bridging Practice and Theory: A Design Science Approach

Despite ambitious efforts in various fields of research over multiple decades, the goal of making academic research relevant to the practitioner remains elusive: theoretical and academic research interests do not seem to coincide with the interests of managerial practice. This challenge is more fundamental than knowledge transfer, it is one of diverging knowledge interests and means of knowledge production. In this paper, we look at this fundamental challenge through the lens of design science, which is an approach aimed primarily at discovery and problem-solving as opposed to accumulation of theoretical knowledge. We explore in particular the ways in which problem-solving research and theory-oriented academic research can complement one another. In operations management (OM) research, recognizing and building on this complementarity is especially crucial, because problem-solving-oriented research produces the very artifacts (e.g., technologies) that empirical OM research subsequently evaluates in an attempt to build explanatory theory. It is indeed the practitioner - not the academic scientist - who engages in basic research in OM. This idiosyncrasy prompts the question: how can we enhance the cross-fertilization between academic research and research practice to make novel theoretical insights and practical relevance complementary? This article proposes a design science approach to bridge practice to theory, not vice versa, theory to practice.
IIT at TREC-10

For TREC-10, we participated in the adhoc and manual web tracks and in both the site-finding and cross-lingual tracks. For the adhoc track, we did extensive calibrations and learned that combining similarity measures yields little improvement. This year, we focused on a single highperformance similarity measure. For site finding, we implemented several algorithms that did well on the data provided for calibration, but poorly on the real dataset. For the cross-lingual track, we calibrated on the monolingual collection, and developed new Arabic stemming algorithms as well as a novel dictionary-based means of cross-lingual retrieval. Our results in this track were quite promising, with seventeen of our queries performing at or above the median.
Surgery for Patients With Recalcitrant Plantar Fasciitis

Background: Plantar fasciitis is a common cause of foot pain, and although many episodes are self-limiting with short duration, 10% leave chronic symptoms. Recalcitrant cases can be managed surgically, with studies demonstrating good results in the short term but uncertainties over longer term outcomes. Purpose: To assess the outcome following surgical intervention for patients with plantar fasciitis. Study Design: Case series; Level of evidence, 4. Methods: Seventy-nine patients were identified from operative diaries undergoing plantar fasciotomy surgery between 1993 and 2009. They were contacted to investigate long-term results using self-reported outcome measures. Results: Sixty-eight responses were received (86% response rate), with an average of 7 years (range, 1-15 years) of follow-up. Patients reported an average reduction in pain by visual analog scale of 79%, and 84% of patients were happy with the surgical results. Greater success was achieved in patients with shorter duration of symptoms preoperatively. No deterioration in success was seen over time. Conclusion: Plantar fasciotomy surgery for plantar fasciitis remains controversial, with biomechanical arguments against surgery; however, this article reports good success following surgery over a long follow-up period. The results of current operative techniques need to be fully investigated for longer term success, as do the outcomes of newer nonoperative management strategies.
Intelligent computer-based systems for anaesthesia control in hospital operating rooms

Anaesthetists have a “triad” of responsibilities in hospital operating rooms,being that of muscle relaxation,unconsciousness and pain relief.Computer-based control systems for these applications are described in this lecture.The simpler aspect of muscle relaxation is described first,using Self Organising Fuzzy Logic Control (SOFLC). In contrast,the monitoring and control of unconsciousness under surgical conditions in operating theatre is a major challenge to both anaesthetists and machines. An intelligent system has been developed for the assessment of depth of anaesthesia which utilises auditory evoked brain potentials, heart rate and blood pressure measurements. Using wavelets analysis the features within the auditory evoked signals are extracted and then fed to a learning neuro-fuzzy system which in turn classifies the depth of anaesthesia. In addition, the heart rate and blood pressure signals are used as a second measure based on a rule-based fuzzy logic system. The two measures are then fused to give a final indication of anaesthetic depth. This is then fed back to a Target Controlled Infusion (TCI) system for regulating the infusion of the drug propofol for the maintenance of anaesthetic state. The architecture has been validated via extensive simulation and in clinical trials. The system has also been developed as a computer-based training device.
Predictors of newly diagnosed atrial fibrillation in cryptogenic stroke: a cohort study

A significant proportion of cryptogenic ischaemic strokes are due to paroxysmal atrial fibrillation (AF). As paroxysmal AF appears to inexorably progress to persistent or permanent AF, this study with long‐term follow‐up was designed to establish the profile of patients who developed AF after hospital discharge.
Extra scrutiny for industry funded trials

JAMA's demand for an additional hurdle is unfair—and absurd S uppose that a biomedical journal invoked a new policy requiring that all authors based in western Europe or North America would receive ordinary peer review, but authors from other countries would receive a peer review with additional hurdles. This policy may seem unfair, but suppose the journal claimed that research has shown that there is a greater prevalence of fraud, bias, and sloppy work among papers coming from these other countries. If these events actually transpired, we hope that other biomedical journals would rapidly point out that adopting such a policy would be unfair to authors from non-western countries, even if the premises for it were valid. Indeed, we hope that other editors would decide that it would be unethical to create any hierarchical system for submissions of papers to a biomedical journal. Peer review ought to rest …
Monitoring of plexiform neurofibroma in children and adolescents with neurofibromatosis type 1 by [18F]FDG‐PET imaging. Is it of value in asymptomatic patients?

About 10% of patients with neurofibromatosis type 1 (NF‐1) develop malignant peripheral nerve sheath tumours (MPNST) mostly arising in plexiform neurofibroma (PN); 15% of MPNST arise in children and adolescents. 2‐[18F]fluoro‐2‐deoxy‐d‐glucose ([18F]FDG)‐PET (where PET is positron emission tomography) is a sensitive method in differentiating PN and MPNST in symptomatic patients with NF‐1. This study assesses the value of [18F]FDG‐PET imaging in detecting malignant transformation in symptomatic and asymptomatic children with PN.
T-Cell detector maturation algorithm based on cooperative co-evolution GA

Efficient T-cell detector maturation algorithm is one of the most important problems of anomaly detection. Aiming at solving problems of current algorithms, such as low TP value, fixed matching threshold value and large detector set size. A novel T-detector maturation algorithm based on cooperative co-evolution genetic algorithm is put forward in this paper. According to morphologic analysis of intrusion detection system and covering problem algorithm. And then each population evolves according to each self partition and their best population would be combined as the final matured detector set, which decreases redundancy of detectors and maintains diversity of detectors. The efficiency is proved by theoretical foundation and tests.
a nonlinear generalization of cointegration: a note on hidden cointegration

In this paper, we stress the nonstandard properties characterizing the peculiar form of cointegration recently suggested by Granger and Yoon (2002). We show that although being linear in the cumulative positive and negative changes of the data, the nonlinear stochastic structure of the relation calls for specific estimation and testing procedures. This can be done straightforwardly by augmenting the cointegration relation with the complement to the first dierence of the dependent variable. The theory is applied to the exchange rate dynamics.
Fault detection for nonlinear systems - a standard problem approach

The paper describes a general method for designing (nonlinear) fault detection and isolation (FDI) systems for nonlinear processes. For a rich class of nonlinear systems, a nonlinear FDI system can be designed using convex optimization procedures. The proposed method is a natural extension of methods based on the extended Kalman filter.
Rethinking Interaction: From Instrumental Interaction to Human-Computer Partnerships

The extraordinary advances in hardware and networking technology over the past 50 years have not been matched by equivalent advances in software. Today's interactive systems are fraught with limitations and incompatibilities: they lack interoperability and flexibility for end users. The goal of this workshop is to rethink interaction by identifying frameworks, principles and approaches that break these limitations and create true human-computer partnerships.
The vertical profiles of H2O, O2 and CO in the martian atmosphere derived from Herschel/HIFI observations

Mars has been observed by the Heterodyne Instrument for the Far Infrared (HIFI) [1] on the Herschel Space Observatory [2] as part of our solar system key programme HssO [3] during two periods. They cover parts of the late martian Northern spring (April 11-16, 2010, Ls= 76-78) and early Northern summer (June 23 - July 6, 2010, Ls= 108-114). A number of dedicated line observations have been performed [4,5] as well as line surveys in the HIFI bands 1 to 6. This presentation will focus on the determination of the vertical profiles of water vapour, molecular oxygen and carbon monoxide derived from the resolved molecular line shapes. Furthermore, the upper limits of some selected atmospheric trace gases will be presented.
Extract Enriched in Flavan-3-ols and Mainly Procyanidin Dimers Improves Metabolic Alterations in a Mouse Model of Obesity-Related Disorders Partially via Estrogen Receptor Alpha

Red wine polyphenol extracts improve cardiovascular and metabolic disorders linked to obesity. Their vascular protection is mediated by the activation of the alpha isoform of the estrogen receptor (ERα). In the present study, we explored the effects of a grape seed extract (GSE) enriched in the flavan-3-ols procyanidin dimers on obesity-related cardiovascular and metabolic disorders; with a particular interest in the role/contribution of ERα. Ovariectomized wild type or ERα knockout (KO) mice were fed with standard or western diet, supplemented or not with GSE, for 12 weeks. Their body weight was monitored throughout the study, and an echocardiography was performed at the end of the treatment. Blood and tissues were collected for biochemical and functional analysis, including nitric oxide and oxidative stress measurement. Vascular reactivity and liver mitochondrial complexes activity were also analyzed. In western diet-fed mice, GSE reduced adiposity, plasma triglycerides, and oxidative stress in the heart, liver, adipose and skeletal tissues; but did not improve the vascular dysfunction. In western diet-fed mice, ERα deletion prevented or reduced the beneficial effects of GSE on plasma triglycerides and visceral adiposity. ERα deletion also prevented/reduced the anti-oxidant effect of GSE in the liver, but did not affect its capacity to reduce oxidative stress in the heart and adipose tissue. In conclusion, dietary supplementation of GSE attenuated features of metabolic syndrome partially through ERα-dependent mechanisms. This report highlights the therapeutic potential of polyphenols, and especially extract enriched in procyanidin dimers, against the metabolic disorders associated with excessive energy intake.
Video frame alignment in multiple views

Many events are captured using multiple cameras today. Frames of each video stream have to be synchronized and aligned to a common time axis before processing them. Synchronization of the video streams necessarily needs a hardware based solution that is applied while capturing. The alignment problem between the frames of multiple videos can be posed as a search using traditional measures for image similarity. Multiview relations and constraints developed in Computer Vision recently can provide more elegant solutions to this problem. In this paper, we provide two solutions for the video frame alignment problem using two view and three view constraints. We present solutions to this problem for the case when the videos are taken using affine cameras and for general projective cameras. Excellent experimental results are achieved by our algorithms.
Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor-negative breast cancer survival.

BACKGROUND Traditional prognostic factors for survival and treatment response of patients with breast cancer do not fully account for observed survival variation. We used available genotype data from a previously conducted two-stage, breast cancer susceptibility genome-wide association study (ie, Studies of Epidemiology and Risk factors in Cancer Heredity [SEARCH]) to investigate associations between variation in germline DNA and overall survival. METHODS We evaluated possible associations between overall survival after a breast cancer diagnosis and 10 621 germline single-nucleotide polymorphisms (SNPs) from up to 3761 patients with invasive breast cancer (including 647 deaths and 26 978 person-years at risk) that were genotyped previously in the SEARCH study with high-density oligonucleotide microarrays (ie, hypothesis-generating set). Associations with all-cause mortality were assessed for each SNP by use of Cox regression analysis, generating a per rare allele hazard ratio (HR). To validate putative associations, we used patient genotype information that had been obtained with 5' nuclease assay or mass spectrometry and overall survival information for up to 14 096 patients with invasive breast cancer (including 2303 deaths and 70 019 person-years at risk) from 15 international case-control studies (ie, validation set). Fixed-effects meta-analysis was used to generate an overall effect estimate in the validation dataset and in combined SEARCH and validation datasets. All statistical tests were two-sided. RESULTS In the hypothesis-generating dataset, SNP rs4778137 (C>G) of the OCA2 gene at 15q13.1 was statistically significantly associated with overall survival among patients with estrogen receptor-negative tumors, with the rare G allele being associated with increased overall survival (HR of death per rare allele carried = 0.56, 95% confidence interval [CI] = 0.41 to 0.75, P = 9.2 x 10(-5)). This association was also observed in the validation dataset (HR of death per rare allele carried = 0.88, 95% CI = 0.78 to 0.99, P = .03) and in the combined dataset (HR of death per rare allele carried = 0.82, 95% CI = 0.73 to 0.92, P = 5 x 10(-4)). CONCLUSION The rare G allele of the OCA2 polymorphism, rs4778137, may be associated with improved overall survival among patients with estrogen receptor-negative breast cancer.
From two to three dimensions: The importance of the third dimension for evaluating the limits to neuronal miniaturization in insects

Most studies dealing with the limits to miniaturization in insect brains have until now relied on information based on data collected in two dimensions: either histological sections imaged by light microscopy, or electron micrographs of single ultrathin sections imaged by transmission electron microscopy (TEM). To test the validity of transferring information gained from two‐dimensional images to the third dimension, we examined a 3D image stack from serial‐section TEM (ssTEM) of the optic neuropiles of the miniature parasitic wasp Trichogramma brassicae (Bezdenko, 1968). We reinvestigated the proposed lower limit of 2 µm for the diameters of neuronal somata and found average volumes of 6.5 μm3 for lamina cells and 3.8 μm3 for medulla cells. We likewise found a limiting factor for the volume of nuclei, which averages 41.9% and 49.2% of the cell body volume, respectively, but that in turn the compactness of heterochromatin was not a limiting factor in the minimal volume of the nuclei. Finally, we also found a minimum axon diameter of 98 nm that could nevertheless accommodate axoplasmic mitochondria. Incorporating the third dimension thus proves critically important in avoiding volumetric misinterpretations of these values. We discuss the limitations of analyzing the effects of miniaturization from profile data of neurons and demonstrate that miniaturization within the nervous system can lie beyond previously described limits and in some cases is already present in the optic lobe neurons of T. brassicae.
Distributed priority queues on hypercube architectures

We efficiently map a priority queue on the hypercube architecture in a load balanced manner, with no additional communication overhead. Two implementations for insert and deletemin operations are proposed on the single-port hypercube model. In a b-bandwidth, n-item priority queue in which every node contains b items in sorted order, the first implementation achieves optimal speed-up of O[min{log n, b(log n)/(log b+log log n)}] for inserting b pre-sorted items or deleting b smallest items, where b=O(n/sup 1/c/) with c>1. In particular, single insertion and deletion operations are cost-optimal and require O(log n/p+log p) time using O(log n/log log n) processors. The second implementation is more scalable since it uses a larger number of processors, and attains a 'nearly' optimal speed-up on the single-port hypercube. The insertion of log n pre-sorted items or the deletion of log n smallest items requires O(log log n)/sup 2/ time and O(log/sup 2/ n/log log n) processors. However, on the slightly more powerful pipelined hypercube model, we are able to reduce the time complexity to O(log log n) thus attaining optimal speed-up. To the best of our knowledge, our algorithms provide the first implementations of b-bandwidth distributed priority queues, which are load balanced and yet guarantee optimal speed-up.
Effect of Proximal Femoral Bone Support on the Fixation of a Press-Fit Noncemented Total Hip Replacement Femoral Component

Purpose Proximal femoral bone loss is a common challenge in revision hip arthroplasty. In this study, in vitro fixation of a non-cemented, rectangular, dual-tapered, press-fit femoral component designed to achieve metadiaphyseal fixation was analyzed using an accelerated proximal femoral bone loss model to assess the potential use in revision cases. Methods The press-fit Alloclassic™ femoral stem was implanted in ten cadaveric femurs and tested under cyclic biomechanical loading in an intact state, and then again after sequential proximal femoral bone resections, simulating increasing amounts of bone deficiency. Anterior-posterior and medial-lateral interface motions were measured at the distal stem tip throughout loading. Results Three specimens remained stable throughout testing, with initial and peak per-cycle motions of less than 50 μm. Six specimens were destabilized under loading with higher per-cycle motions, specifically at the distal stem tip during peak loading in the anterior-posterior direction, with motions of 78±69 μm, compared to 12±9 μm in the stable specimens (P<.05). Total migration of the destabilized specimens was also significantly higher, specifically at the proximal stem tip in the medial-lateral direction, with migrations of 101±34 μm (P<.05) and at the distal stem tip in the anterior-posterior direction, with migrations of 155±179 μm (P<.05), compared to 33±12 μm and 13±11 μm for the stable specimens. Conclusion The results indicate that when strong initial fixation is achieved, long-term success is possible given substantial proximal femoral bone loss.
Bankruptcy Prediction Using Multiple Classifier System with Mutual Information Feature Grouping

The prediction of bankruptcy helps an organization to choose its business partners and banks to approve or reject loan requests. So, it is essential to predict the bankruptcy of an organization. In this work, a multiple classifier system which combines decision from several different base classifiers trained using different samples with different input features is proposed for the bankruptcy prediction. The input features for each base classifier are selected using its mutual information with respect to the output. Experimental results of the proposed method using a real bankruptcy dataset from Compustat Global Dataset are promising.