Miracle-dz/UniFAR-FTUs huggingface dataset:
Renal allograft immunosuppression: IV. Comparison of Iipid and lipoprotein profiles in blood using double and triple immunosuppressive drug combinations

Abstract. Serum lipid and lipoprotein profiles were performed in order to investigate lipid abnormalities 2 years post‐transplantation in first cadaveric renal allograft recipients immunosuppressed with cyclosporin (CyA), azathioprine (Aza), and methylprednisolone (MP), or with any combination of two drugs. CyA was used in low doses. Total serum cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, HDL2 cholesterol, HDL3 cholesterol, apolipoprotein A1, and apolipoprotein B were determined in 88 prospectively randomized patients with functioning grafts. When considering only the patients who remained on the original randomized treatment, there were no significant differences between the four groups in any of the measured variables. Mean total cholesterol was highest in the group receiving Aza and MP (6.8 mmol/l) and lowest in the group receiving triple therapy (5.8 mmol/l; NS). Mean triglyceride level was highest in the group receiving Aza and MP (2.3 mmol/1) versus 1.8–2.2 mmol/l in the groups receiving triple therapy, Aza + CyA, and CyA + MP. For all patients mean triglyceride level was highest in the group receiving Aza and MP (2.7 mmol/1) and lowest in the group receiving triple therapy (1.7 mmol/l; P<0.05). Mean HDL cholesterol ranged from 1.5 to 1.6 mmol/l in all groups. Neither CyA concentration nor CyA or MP dose correlated with cholesterol or triglyceride concentration. However, the average MP dose was twice as high in the group receiving Aza and MP as in the other two groups employing steroids. Serum cholesterol and triglyceride concentrations were related to body mass index (r= 0.28, P= 0.045 and r= 0.30, P= 0.029, respectively). Hyperlipidemia was most common in the group receiving Aza and MP, The frequency of hypercholesterolemia (serum cholesterol level > 6.5 mmol/1) was 18%, 45%, 60%, and 35% for the patients continuing with the originally randomized treatment in the groups receiving triple therapy, Aza + CyA, Aza + MP, and CyA + MP, respectively. In a normal Finnish reference population, 35% of all males and 31% of allfemaleshaveaserumcholesterollevel above 6.5 mmol/l. Thus, only patients receiving Aza and MP had a clearly higher frequency of hypercholesterolemia than that found in a normal population. Taken together, this study shows no lipid abnormalities associated with the use of low‐dose CyA for 2 years after transplantation. Hyperlipidemia occurring after transplantation is probably multifactorial and more associated with other risk factors than with the immunosuppressive therapy.
Icarus: a caching simulator for information centric networking (ICN)

Information-Centric Networking (ICN) is a new networking paradigm proposing a shift of the main network abstraction from host identifiers to location-agnostic content identifiers. So far, several architectures have been proposed implementing this paradigm shift. A key feature, common to all proposed architectures, is the in-network caching capability, enabled by the location-agnostic, explicit naming of contents. This aspect, in particular, has recently received considerable attention by the research community. However, despite this wide interest, there is a shortage of publicly-available tools suitable for evaluating the performance of caching systems effectively. In fact, all available simulators or emulators are either bound to a specific architecture or cannot execute simulations at the scale required and within a reasonable time-frame. To address these issues, we present Icarus, a Python-based caching simulator for ICN. Icarus allows users to evaluate caching strategies for any ICN implementation and also provides modelling tools useful for caching research.
Measuring and analyzing Random Telegraph Noise in Nanoscale Devices: The case of resistive random access memories

In this paper, we discuss some of the measurement and analysis techniques for Random Telegraph Noise (RTN). Due to its detrimental impact on devices, RTN mechanism must be investigated and integrated into device models. However, RTN analysis requires a self-consistent framework in which automated measurement techniques, data analysis procedures, and physics-based modeling are blended together. Here we discuss guidelines to perform corrrect RTN measurements, and statistical techniques to perform advanced data analysis. This allows getting reliable results, which can lead to an unbiased physical interpretation of the phenomenon. The statistical analysis of RTN measured in hafnium oxide RRAM devices allows revealing the mechanism leading to the wide RTN fluctuations in high-resistive state, as well as the physical properties of the defect species involved in this phenomenon.
Field-Induced Structures in Ferrofluid Emulsions.

The field-induced structure in a monodisperse ferrofluid emulsion is studied. An applied magnetic field induces a magnetic dipole moment in each droplet. When the dipole-dipole interaction energy exceeds the thermal energy, a phase transition occurs as the fluid of randomly dispersed droplets changes to a solid of nearly equally sized and spaced columns. Our results show that the column spacing follows a relation ${d\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}1.33L}^{0.37}$ for cell thickness $3\ensuremath{\le}L\ensuremath{\le}800\ensuremath{\mu}\mathrm{m}$. A new theory, which treats the column shape more realistically, is developed to account for the results.
SyDeR—System design for reusability

A fixed set of components with a fixed set of properties is often regarded as a defining characteristic of configuration design problems. In configuration design for larger and more complex systems (e.g., street cars), however, this often is not really true. The reason is that sometimes the component library offers no component that meets the actual requirements, so that a new component has to be added to the library. In general, configuration design for larger products must be interactive: interactive in the sense that the user controls the configuration process and in the sense that the phases of knowledge acquisition and configuration are partly mixed. This paper describes a method and a corresponding software tool (SyDeR, System Design for Reusability) that support the interactive configuration design of complex products, especially in the tendering phase. It combines three different technologies: [bull ] structural modeling of technical systems; [bull ] a library for technical solutions, which is based upon taxonomies and allows the reuse of the technical solutions; [bull ] constraint techniques to propagate design decisions and check designs for consistency to support interactive configuration design. This paper gives an overview of the functionality of the SyDeR tool and describes the main ideas behind the modeling language, which is especially oriented towards the requirements of system design problems. It also explains how we integrated structural modeling, taxonomies, and advanced constraint reasoning techniques into real-world applications.
Does Occupational Mobility Influence Health among Working Women? Comparing Objective and Subjective Measures of Work Trajectories

Occupational mobility is highly valued in American society, but is it consequential to women’s health? Previous studies have yielded inconsistent results, but most measured occupational mobility by identifying transitions across occupational categories. Drawing from cumulative inequality theory, this study (1) compares objective and subjective measures of work trajectories and (2) examines the contributions of each to self-rated health. With 36 years of data from the National Longitudinal Survey of Mature Women (1967-2003), growth curve models are used to estimate the effects of middle-aged work trajectories on health among 2,503 U.S. women. Work trajectories as measured by the Duncan Socioeconomic Index predict health, but not after adjustment for perceived work trajectories and status characteristics. The findings reveal that subjective measures of occupational mobility provide important information for assessing health consequences of work transitions and that downward occupational mobility in middle age is deleterious to women’s health in later life.
Emerging tools for real‐time label‐free detection of interactions on functional protein microarrays

The availability of extensive genomic information and content has spawned an era of high‐throughput screening that is generating large sets of functional genomic data. In particular, the need to understand the biochemical wiring within a cell has introduced novel approaches to map the intricate networks of biological interactions arising from the interactions of proteins. The current technologies for assaying protein interactions – yeast two‐hybrid and immunoprecipitation with mass spectrometric detection – have met with considerable success. However, the parallel use of these approaches has identified only a small fraction of physiologically relevant interactions among proteins, neglecting all nonprotein interactions, such as with metabolites, lipids, DNA and small molecules. This highlights the need for further development of proteome scale technologies that enable the study of protein function. Here we discuss recent advances in high‐throughput technologies for displaying proteins on functional protein microarrays and the real‐time label‐free detection of interactions using probes of the local index of refraction, carbon nanotubes and nanowires, or microelectromechanical systems cantilevers. The combination of these technologies will facilitate the large‐scale study of protein interactions with proteins as well as with other biomolecules.
Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies

Parkinson's disease (PD) patients progressively accumulate intracytoplasmic inclusions formed by misfolded α-synuclein known as Lewy bodies (LBs). LBs also contain other proteins that may or may not be relevant in the disease process. To identify proteins involved early in LB formation, we performed proteomic analysis of insoluble proteins in a primary neuron culture model of α-synuclein pathology. We identified proteins previously found in authentic LBs in PD as well as several novel proteins, including the microtubule affinity-regulating kinase 1 (MARK1), one of the most enriched proteins in this model of LB formation. Activated MARK proteins (MARKs) accumulated in LB-like inclusions in this cell-based model as well as in a mouse model of LB disease and in LBs of postmortem synucleinopathy brains. Inhibition of MARKs dramatically exacerbated α-synuclein pathology. These findings implicate MARKs early in synucleinopathy pathogenesis and as potential therapeutic drug targets. SIGNIFICANCE STATEMENT Neurodegenerative diseases are diagnosed definitively only in postmortem brains by the presence of key misfolded and aggregated disease proteins, but cellular processes leading to accumulation of these proteins have not been well elucidated. Parkinson's disease (PD) patients accumulate misfolded α-synuclein in LBs, the diagnostic signatures of PD. Here, unbiased mass spectrometry was used to identify the microtubule affinity-regulating kinase family (MARKs) as activated and insoluble in a neuronal culture PD model. Aberrant activation of MARKs was also found in a PD mouse model and in postmortem PD brains. Further, inhibition of MARKs led to increased pathological α-synuclein burden. We conclude that MARKs play a role in PD pathogenesis.
Two-point discrimination test. A valuable part of hand surgical rehabilitation, e.g. in tetraplegia.

In assessing the prospects for surgical and other kinds of rehabilitation in tetraplegia and stroke patients the two-point discrimination test, correctly performed by experienced examiners, is of great value. Valid and repeatable results depend on exact technique and proper tools. There is a firm correlation between the thresholds of two-point discrimination on the pulps of the fingers and the accuracy of position sense at the metacarpophalangeal and interphalangeal joints. Microneurography has shown that cutaneous receptors have proprioceptive as well as exteroceptive functions. Thus the two-point discrimination test can be used as a measure of proprioceptive function. The results can be expressed numerically. A two-point threshold less than 10 mm on the pulp is a valid measure of useful finger proprioception. It also shows tactile gnosis, necessary for precision sensory grips.
Architektur für verteilte, fehlertolerante Sensor-Aktor-Systeme

Sensor Marzullo [Mar90] zeigt in seiner Arbeit die fehlertolerante Erfassung von gleichartigen Sensordaten in einem verteilten System. Dafür werden die als Concrete Sensors bezeichneten Sensoren in ihrer individuellen Ausprägung durch einen Abstract Sensor gekapselt. Dieser übernimmt die Abbildung der realen Messung auf einem wertkontinuierlichen Fenster, wobei eine gleich verteilte Streuung des Wertes angenommen wird. Entsprechend der Darstellung in Abbildung 3.5, fasst ein nachgeordneter fehlertoleranter Abstract Sensor n Abstract Sensors mit einer gleichartigen Messgröße zusammen und schließt dabei, ausgehend von einer vordefinierten Anzahl von maximal gleichzeitig möglichen Fehlern, auf eventuell defekte Messsysteme. Diese werden dann von der eigentlichen Fusion ausgeschlossen. Marzullo weist mathematisch nach, dass es für verschiedene Fehlertypen einer genau bestimmbare Mindestanzahl an Abstract Sensors bedarf, um diese sicher zu detektieren. Verschiedene Autoren greifen zum Beispiel L. Prasad u. a. [L. +93] oder Jayasimha [Jay94] den Fehlerdetektionsansatz des Abstract Sensors auf, erweitern die Anwendbarkeit auf zweidimensionale Sensoren und stellen einen verfeinerten Algorithmus zur Fehlerdetektion vor. Qi, Iyengar und Chakrabarty [QIC01] vergleichen die Resultate dieser Ansätze anhand eines Beispiels und diskutieren die Vorund Nachteile.
A Methodology of Predicting Market Convergence Opportunity Using Machine Learning for Small and Mid-Size Enterprises

Technology and product innovation through fusion became essential for survival of SMEs. This paper presents a method to develop a platform to discover the opportunity of market convergence by using product databases from a global B2B marketplace. Currently, there are huge researches that focus on patent databases which are capable of detecting technology convergence. However, these methods have failed to recognize market convergence which reflects customer demands. We attempt to identify opportunity by jointly applying technology trends and market requirements. This paper presents the following three mechanisms for technology convergence platform building: item discovery for technology commercialization, recommendation for converged item, and collaborative network for inter-enterprises. The results of our study are expected to contribute to the firms that exploit new market-based convergence opportunity.
Fast Summarization of User-Generated Videos Using Semantic , Emotional and Quality Clues

This paper introduces a novel approach for fast summarization of user-generated videos (UGV). Different from other types of videos where the semantic contents may vary greatly over time, most UGVs contain only a single shot with relatively consistent high-level semantics and emotional content. Therefore, a few representative segments are generally sufficient for a summary, which can be selected based on the segment-level semantic and emotional recognition results. In addition, due to the poor shooting quality of many UGVs, factors such as camera shaking and lighting condition are also considered to achieve more pleasant summaries.
Modeling thermal conductivity and collective effects in a simple nanofluid

Molecular dynamics simulations are used to model the thermal properties of a fluid containing solid nanoparticles (nanofluid). The flexibility of molecular simulation allows us to consider the effects of particle mass, particle-particle and particle-fluid interaction and that of the spatial distribution of the particles on the thermal conductivity. We show that the heat conductivity of a well dispersed nanofluid is well described by the classical Maxwell Garnett equation model. In the case of particle clustering and strong inter particle interactions the conductivity can be again described by effective medium calculation taking into account the aspect ratio of the cluster. Heat transfer is increased when particles are aligned in the direction of the temperature gradient. This kind of collective effects could be a first step to understand the substantial increase in the conductivity observed in some experiments.
Business models for frugal innovation : the role of Resource-Constraints

Frugal Innovation is an extreme case of innovation: radically new applications are innovated for an environment of extreme resource and cost constraints. While the phenomenon of frugal innovation has been described from a product perspective, very little is known about how firms organize frugal innovation on a business model level. This study is based on a multiple case study approach investigating five business models for frugal innovation in the context of the medical equipment market in emerging economies. We find that there exists an overarching frugal business logic, based on which firms can establish different business models.
Current Differential Protection of Transmission Line Using the Moving Window Averaging Technique

We propose a new approach to current differential protection of transmission lines. In this approach, we transform the instantaneous line current(s) by using a moving window averaging technique. If the time span of moving window is equal to one-cycle time, then the steady-state value of the transformed current is zero for a periodic signal which is composed of fundamental and harmonic frequencies. Signal distortions (e.g., a fault) cause the transformed currents to deviate from the nominal zero value. This permits the development of a sensitive, secure, fast, and yet simple current differential protection scheme. The scheme can be applied in toto to series-compensated transmission lines. Results on a four-machine ten-bus system and comparative evaluation with state-of-the-art methods brings out promise of the proposed method.
The Determinant Factors of Employees' Behavioral Intention in Green Building Restaurants - Integration TRA and TAM

This study integrated with technology acceptance model (TAM) and theory of reasoned action (TRA) to construct a behavior model of green building restaurants. On the basis of TAM analysis, four constructs were identified: perceived usefulness, perceived ease of use, attitude and intention. Three constructs were identified from TRA: motivation to comply, subjective norm and intention. The results shown: first, perceived usefulness, and perceived ease of use green building restaurants in Taiwan has an indirect effect on intention through attitude; second, motivation to comply has indirect effect passes through both subjective norm and attitude sequentially, with subjective norm affecting attitude. Finally, motivation to comply has an indirect effect on intention through subjective norm.
Remembering the Forgotten: Psychotherapy Groups for the Nursing Home Resident

Abstract The mental health needs of the long–term nursing home resident receive little attention. It is especially difficult for the more cognitively intact resident to obtain psychological help. An integrated group psychotherapy model that incorporates developmental, cognitive–behavioral, and psychodynamic approaches is described, based on the author’s clinical experience in developing and co–leading four groups in three long–term care facilities over a period of ten years. The technical and countertransference challenges of working with this unique population and in this format are described, along with clinical material to illustrate common themes. The success of the groups in improving the morale, sense of community, and quality of life for group members is demonstrated.
Optimizing internal logistic flows in hospitals by dynamic pick-up and delivery models

In the present contribution, the application of a dynamic pick-up and delivery model for hospital internal logistics is investigated. Two scheduling policies are developed: the first applies a cheapest insertion heuristic targeting optimization of the problem’s objective function, while the second employs local search to improve the current schedule. A computational study is presented in which the two policies are applied on a range of generated problem instances that have been made available to the research community. The benefit of the two policies is demonstrated by comparing them with a common and intuitive earliest first, by due date policy. Secondly, the benefit of allowing to combine transports is also investigated, and it is shown that this may lead to further increased performance.
Leukemia inhibitory factor, LIF receptor, and gp130 in the mouse uterus during early pregnancy

Leukemia inhibitory factor (LIF) has been shown to play an important role in the implantation of mouse blastocysts. The present study was designed to investigate the changes of LIF protein, LIF receptor, and gp 130 in the mouse uterus during the early pregnancy. LIF protein and LIF receptor were at high levels in the mouse uterus near the time of ovulation and on day 4 of pregnancy. gp 130 was highest on days 3 and 4 of pregnancy. Both LIF receptor and gp 130 showed strong staining in the stroma of the day 5 uterus, at a time when LIF protein was low. The presence of LIF receptor and gp 130 in the luminal epithelium on day 4 and in the stroma on day 5 may indicate the site of the high affinity LIF receptor. The coexistence of a high level of LIF protein, LIF receptor, and gp 130 in the day 4 uterus is consistent with the previously observed high level of uterine LIF mRNA on the same day and the importance of LIF for the blastocyst implantation in mouse. © 1995 wiley‐Liss, Inc.
How Risk-Mitigating Are the ECB's Unconventional Monetary Policy Announcements? Evidence from Risk-Neutral Densities

In the aftermath of the financial crisis in 2008 and over the course of the European debt crisis, the ECB announced a number of unconventional monetary policy implementations with the aim of restoring confidence in the functioning of the European financial system. This paper studies the effect of financial turmoil and unconventional monetary policy announcements on the risk perception of market participants. Using a large data set covering the time period from pre-crisis 2006 until the end of 2013, I provide empirical evidence that the deteriorated market conditions cause the shape of the risk-neutral density to significantly differ from that in more stable market environments. Furthermore, the results suggest that direct purchase programs such as the Covered Bond Purchase Program (CBPP) and the Securities Market Program (SMP) have a risk-mitigating effect on the risk assessment of the market whereas instruments that indirectly intervene in the financial market through improved lending operations further increase the tail risk.
A polynomial phase parameter estimation-phase unwrapping algorithm

This paper describes a new approach for estimating the polynomial phase coefficients of an unknown signal with constant amplitude. Our approach uses linear regression on the unwrapped signal phase, a technique introduced by Tretter (1981) and further developed by Djuric and Kay (see IEEE Trans. on Signal Processing, vol.38, no.12, p.2118-2126, 1990). The proposed technique expands upon the previous work by developing a recursion for conducting the phase unwrapping concurrently with the coefficient estimation. The unwrapping performance is improved because of the use of current coefficient estimates. A secondary result provided by the new algorithm is an instantaneous phase estimate. Simulations show improvements in mean-squared error threshold level of the coefficient estimates over the method of Djuric and Kay. <<ETX>>