Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantum Criticism: A Tagged News Corpus Analysed for Sentiment and Named Entities

In this research, we continuously collect data from the RSS feeds of traditional news sources. We apply several pre-trained implementations of named entity recognition (NER) tools, quantifying the success of each implementation. We also perform sentiment analysis of each news article at the document, paragraph and sentence level, with the goal of creating a corpus of tagged news articles that is made available to the public through a web interface. Finally, we show how the data in this corpus could be used to identify bias in news reporting.
Ursodeoxycholic acid inhibits interleukin beta 1 and deoxycholic acid‐induced activation of NF‐κB and AP‐1 in human colon cancer cells

Deoxycholic acid (DCA) has been implicated in colorectal carcinogenesis in humans with effects on proliferation and apoptosis, mediated at least in part by activation of transcription factors nuclear factor kappa B (NF‐κB), activator protein 1 (AP‐1) and protein kinase C (PKC) enzymes. Ursodeoxycholic acid (UDCA) is reported to reduce the frequency of colonic carcinogenesis in ulcerative colitis patients. Hence, we postulated that it might differ from DCA in its regulation of these transcription factors. The aim of the study was to determine effects of DCA and UDCA on NF‐κB and AP‐1 activation and explore its relationship to PKC. Human colonic tumour cell lines HCT116 were treated with DCA, UDCA, alone or pretreated with UDCA followed by DCA or IL‐1β. In other experiments, cells were pretreated with PKC inhibitors and then stimulated with DCA and IL‐1β or PMA. Gel shift assays were performed on nuclear extracts of the cells for NF‐κB and AP‐1 analysis. Western blot analyses and immunofluorescence were performed for Rel A (p65) and IκB‐α levels on the treated cells. DCA increased NF‐κB and AP‐1 DNA binding. UDCA did not increase DNA binding of NF‐κB and AP‐1 and UDCA pretreatment inhibited DCA‐induced NF‐κB and AP‐1 DNA binding. PKC inhibitors blocked DCA‐induced NF‐κB and AP‐1 activation. These results were validated by Western blot analysis for RelA and IκB‐α. In conclusion, UDCA did not induce NF‐κB and AP‐1 DNA binding but also blocked DCA‐induced NF‐κB and AP‐1 activation. These findings suggest a possible mechanistic role for UDCA in blocking pathways thought to be involved in colon carcinogenesis. © 2005 Wiley‐Liss, Inc.
GAS, STARS, AND STAR FORMATION IN ALFALFA DWARF GALAXIES

We examine the global properties of the stellar and H i components of 229 low H i mass dwarf galaxies extracted from the ALFALFA survey, including a complete sample of 176 galaxies with H i masses <107.7 M☉ and H i line widths <80 km s−1. Sloan Digital Sky Survey (SDSS) data are combined with photometric properties derived from Galaxy Evolution Explorer to derive stellar masses (M*) and star formation rates (SFRs) by fitting their UV–optical spectral energy distributions (SEDs). In optical images, many of the ALFALFA dwarfs are faint and of low surface brightness; only 56% of those within the SDSS footprint have a counterpart in the SDSS spectroscopic survey. A large fraction of the dwarfs have high specific star formation rates (SSFRs), and estimates of their SFRs and M* obtained by SED fitting are systematically smaller than ones derived via standard formulae assuming a constant SFR. The increased dispersion of the SSFR distribution at M* ≲ 108 M☉ is driven by a set of dwarf galaxies that have low gas fractions and SSFRs; some of these are dE/dSphs in the Virgo Cluster. The imposition of an upper H i mass limit yields the selection of a sample with lower gas fractions for their M* than found for the overall ALFALFA population. Many of the ALFALFA dwarfs, particularly the Virgo members, have H i depletion timescales shorter than a Hubble time. An examination of the dwarf galaxies within the full ALFALFA population in the context of global star formation (SF) laws is consistent with the general assumptions that gas-rich galaxies have lower SF efficiencies than do optically selected populations and that H i disks are more extended than stellar ones.
The Study on the Impact of Political Connection on the Performance of Cross-border Mergers and Acquisitions

With the development of economic globalization, more and more enterprises in China have exploited overseas markets through cross-border M&A activities and enhanced their international competitiveness. Compared with developed countries, China's distinctive political environment and policy changes in keeping pace with the times have a great impact on cross-border M&A activities. The relationship between enterprises and the government has an important impact on cross-border M&A performance. Based on the sample of 108 cross-border M&A cases of A-share listed companies from 2008 to 2014, this paper studies the impact of political connection on cross-border M&A performance, adopting the assignment method to measure the political connection. The results show that political connections have significant positive effects on cross-border M&A performance and the relationship is affected by the government intervention. The greater the degree of government intervention, the weaker the positive effect of political connections on cross-border M&A performance.
Pathophysiology of clozapine induced sialorrhea and current treatmant choices

Clozapine has been used for approximately 40 years and it is still the gold standard for treatment resistant schizophrenia even though it may cause considerable side effects. One of the common side effects during the treatment with clozapine is sialorrhea. Although clozapine has anticholinergic side effects, pathogenesis of sialorrhea is still unclear. Despite sialorrhea is quite common and might influence quality of life, treatment choices and their efficacy for this side effect is limited. Thus, in this article, pathophysiology and treatment of clozapin induced sialorrhea is reviewed.
Tissue-Specific Autoantibodies Improve Diagnosis of Primary Sjögren's Syndrome in the Early Stage and Indicate Localized Salivary Injury

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands. Due to the absence of specific clinical manifestations and biomarkers in the early stage, pSS is generally underrecognized. To elucidate the role of the tissue-specific autoantibodies (TSAs), i.e., anti-CA6, anti-SP1, and anti-PSP antibodies, we enrolled 137 pSS patients, 32 secondary Sjögren's syndrome (sSS) patients, and 127 healthy controls (HCs), whose serum and saliva samples were collected. TSA levels were detected by ELISA, and the clinical and laboratory data was reviewed from the medical records. The analysis results showed the following: (1) Compared to HCs, the serum IgA levels of anti-CA6, anti-SP1 and anti-PSP were significantly higher in pSS as well as in sSS patients, and anti-CA6 IgG was also notably higher in pSS patients. (2) The positivity of anti-CA6, anti-PSP and all the three antibodies together were significantly increased in anti-SSA-negative pSS patients. (3) The average IgM levels of anti-CA6 and anti-SP1 decreased as the disease duration extended. (4) The anti-CA6-positive patients have significantly higher levels of serum IgA, while the anti-PSP-positive group has a notably higher serum IgM level. (5) Another autoantibody specific to the salivary glands, anti-α-fodrin antibody, was elevated in TSA-positive patients, especially in the anti-CA6-positive group. (6) Preliminary detection of saliva TSAs showed that all the IgG levels of these three antibodies increased significantly in pSS patients. In conclusion, TSAs improve diagnosis of pSS in the early stage, especially in anti-SSA-negative patients, and their tissue-specific nature indicates localized salivary injury, which deserves further studies to clarify the mechanism.
KISS1 expression in colorectal cancer

Kisspeptins, the products of the KISS1 gene, are involved in cancer invasion, migration, metastasis and angiogenesis, while they induce apoptosis in various cancers. Herein, we studied KISS1 expression in colorectal cancer. We analyzed KISS1 expression using immunohistochemistry and image analysis in normal and malignant tissue samples from 60 patients with colorectal adenocarcinoma. The results correlated with various clinicopathological parameters. The expression of KISS1 was much higher in normal than in malignant colonic mucosa. However, among malignant tissues, KISS1 expression was higher in larger tumors (>4 cm) than in smaller ones (≤4 cm) and in stages III and IV than in stages I and II. In addition, it was higher in patients with lymph node metastases. Moreover, KISS1 levels in the normal mucosa and their difference from those in the malignant mucosa were higher in the right part of the large intestine than in the left one. KISS1 expression is reduced during the malignant transformation of the colonic mucosa and there is a difference in the expression pattern between the right and the left part of the large intestine. However, larger and advanced colorectal tumors express higher KISS1 levels than smaller and localized ones.
The outsider on the inside: Donald Trump’s Twitter activity and the rhetoric of separation from Washington culture

ABSTRACT This project examines how Donald Trump has used Twitter to separate himself rhetorically from the traditional Washington elite and maintain his outsider status while serving as president. I divide Trump’s tweets into four primary categories: “Power”, “Powerless,” “Party,” and “Partyless” tweets. “Power” tweets consist of messages in which Trump either took action or signaled his authority as head of the executive branch, while “Powerless” tweets consist of messages in which Trump spoke with frustration about issues under the purview of the executive branch that the president has the power to act upon but he did not act. “Party” tweets consist of messages in which Trump acknowledged his association with the Republican Party, while “Partyless” tweets consist of messages in which Trump spoke generically about the Republican Party as if he were not a member, framing himself as an independent figure.
hdr-CIELAB and hdr-IPT: Simple Models for Describing the Color of High-Dynamic-Range and Wide-Color-Gamut Images

Proposed method – hdr-CIELAB and hdr-IPT • Addressing HDR questions – Hard intercepts at zero luminance/lightness – Uncertain applicability for color brighter than diffuse white • Replacing the power-function nonlinearities in CILAB and IPT with a more physiologically plausible hyperbolic function – Michaelis-Menten equation
Epitope Mapping of Monoclonal Antibodies Directed to Aminopeptidase A and Their Relevance for Albuminuria in Mice

We have shown previously that injection of specific combinations of anti-aminopeptidase A monoclonal antibodies induces an acute massive albuminuria in mice. This albuminuria is neither dependent on systemic mediators of inflammation nor angiotensin II. In this study, we examined the contribution of two individual antibodies, the enzyme-inhibiting antibody ASD-37 and the non-enzyme-inhibiting antibody ASD-41, in the induction of albuminuria as well as the interactions between these two monoclonals. In addition, we have mapped the epitopes of both antibodies using in vitro coupled transcription/translation of specifically designed cDNA fragments followed by immunoprecipitation, and using peptide enzyme-linked immunosorbent assay in case of a continuous epitope. A single intravenous injection of 4 mg of either ASD-37 or ASD-41 did not induce albuminuria. This dose of ASD-37 did not completely inhibit enzyme activity. The combination of 4 mg ASD-37/41 (1:1 weight ratio) induced albuminuria and almost completely inhibited enzyme activity. Similar results were obtained with a combination of ASD-37/41 in a 1:39 or 39:1 weight ratio. Administration of 2 mg ASD-41 24 h before injection of 2 mg ASD-37 significantly enhanced albuminuria. The epitope of ASD-37 is located at the C-terminal end of aminopeptidase A, whereas the ASD-41 epitope is mapped near the enzyme active site. Our data suggest that ASD-41 modulates the binding of ASD-37 to its epitope and/or vice versa. As a consequence, ASD-37 and ASD-41 act synergistically, not only in inhibiting enzyme activity but also in inducing albuminuria.
Enhancement on capacitor-voltage-balancing capability of a modular multilevel cascade inverter for medium-voltage synchronous-motor drives

This paper discusses both dc-voltage balancing and ac-voltage minimizing of all the floating capacitors in a modular multilevel cascade inverter (MMCI-DSCC) intended for medium-voltage high-power synchronous-motor drives. It presents theoretical and numerical design considerations on both amplitude and phase of three-phase motor currents. A three-phase DSCC inverter with phase-shifted-carrier pulsewidth modulation (PWM) is designed and constructed to drive a 370-V, 15-kW, 75-Hz, six-pole, interior-permanent-magnet synchronous motor loaded with a hypothetical centrifugal compressor. Experimental results show satisfactory performance in dc-voltage balancing and ac-voltage minimizing of all the capacitors.
Vasospastic angina

Objectives: To assess the early results of conversion from atriopulmonary to total cavopulmonary connection in patients with failing Fontan operation. Design: Early clinical and instrumental evaluation of patients undergoing conversion from atriopulmonary to total cavopulmonary connection from April 1999 to November 2000. Setting: Tertiary referral centre for congenital heart disease. Patients: 11 Fontan patients (mean (SD) age 20.9 (6.7) years) with refractory arrhythmias or ventricular dysfunction. Interventions: Total cavopulmonary connection, intraoperative ablation, and AAIR pacemaker implantation. Main outcome measures: Holter monitoring, transoesophageal atrial stimulation, ergometric test, and myocardial scintigraphy at a mean (SD) follow up of 16.8 (5.6) months. Results: One early postoperative death occurred. During follow up three patients had relapse of atrial tachycardia, controlled by medical treatment, and two were pacemaker dependent. Transoesophageal stimulation did not induce atrial tachycardia in any patient. Ergometric test showed a diminished exercise tolerance in all but one patient. Mean minute ventilation and maximum oxygen consumption were 62% and 40% of their respective predicted values. Myocardial scintigraphy showed reversal of rest or exercise dysfunction in five patients and improved systemic ventricular function in seven. Mean basal ejection fraction increased from 39.4% (95% confidence interval (CI) 32% to 46%) to 46.5% (95% CI 41.7% to 51.2%) and ejection fraction on effort from 42.3% (95% CI 33.9% to 50.7%) to 50.2% (95% CI 44.5% to 55.9%). Conclusions: Our data show that total cavopulmonary connection associated with intraoperative ablation and pacemaker implantation allows for better control of arrhythmias and improves ventricular function in the majority of patients with failing Fontan.
Going Beyond Integer Programming with the Omega Test to Eliminate False Data Dependences

Array data dependence analysis methods currently in use generate false dependences that can prevent useful program transformations. These false dependences arise because the questions asked are conservative approximations to the questions we really should be asking. Unfortunately, the questions we really should be asking go beyond integer programming and require decision procedures for a subclass of Presburger formulas. In this paper, we describe how to extend the Omega test so that it can answer these queries and allow us to eliminate these false data dependences. We have implemented the techniques described here and believe they are suitable for use in production compilers. >
Extending MIPSfpga instruction set for navigation data processing

The Article concerns extension of MIPSfpga processor instruction set for acceleration of calculations related to navigation that are performed by FPGA based embedded system. Coordinate system transformation has been chosen as the reference task. Trigonometric functions calculation and multiplication operation have been chosen as acceleration targets as the most extensively used in transformation matrix calculation. UDI interface has been utilized for instruction extension with hardware accelerator. Three different approaches and instruction sets are being compared. The first instruction set is for basic CORDIC accelerator, the second is for CORDIC with integer multiplication unit and the third is for advanced accelerator with multiplication unit and two CORDIC units. It is demonstrated that suggested instruction sets and corresponding hardware accelerators can speed up calculation of transformation matrix up to 624% compared to software implementation with 10.5% increase on overall hardware resources consumption.
Activation of Apolipoprotein AI Gene Expression by Protein Kinase A and Kinase C through Transcription Factor, Sp1*

Our previous finding that insulin induces apolipoprotein AI (apoAI) transcription points to the participation of intracellular signaling. This finding prompted us to ask whether two classical G-protein-coupled signaling pathways requiring activated protein kinase A (PKA) or kinase C (PKC) may also regulate apoAI. Therefore, human hepatoma, Hep G2 cells stably transfected with pAI.474-CAT, a reporter construct spanning −474 to −7 of apoAI DNA fused to chloramphenicol acetyltransferase (CAT) were treated with 10 μm forskolin (FSK) or 50 nm phorbol dibutyrate (PDBu) to activate PKA and PKC, respectively. Results showed that the apoAI promoter activity increased 4–5-fold following 24 h of treatment with either FSK or PDBu. Induction by either agent was blocked with actinomycin D but not the protein synthesis inhibitor, cycloheximide. The PKA inhibitor, PKI 14–22 amide, abrogated induction by FSK, 100 μm8-bromo-cAMP, or 100 ng/ml cholera toxin, but it had no effect on activation via PKC. Similarly, PDBu induction was attenuated by 2 μm of the PKC inhibitor, GF109203X, but it did not affect FSK activity. Next we used deletional constructs to show that the actions of FSK and PDBu required the insulin-responsive core element (IRCE). This motif matched the consensus binding site for the transcription factor, Sp1. The binding of Sp1 to the IRCE was confirmed by gel-retardation and supershift analysis. Site-directed mutagenesis of the IRCE eliminated Sp1 action and induction by FSK or PDBu. Whereas overexpression of Sp1 enhanced basal and FSK or PDBu induced promoter activity, transfection of an antisense oligomer against Sp1 mRNA attenuated both parameters. In summary, activation of PKA or PKC increases apoAI promoter activity. The activity of both signaling pathways is mediated by the IRCE, a motif that binds the transcription factor, Sp1.
Underground Sewage Monitoring System using Internet of Things

These Safety plays a major role in today’s world and it is necessary thatgood safety systems are to be implemented in places of educationand work. This proposed system modifies the existing safety modelinstalled in industries and this system can also be used in homes, villages, cities and offices. Most of the drainage and unused wells are forming toxic gases. The main objective of this system is designing microcontroller based toxic gas detecting, alerting system and gas purification. The hazardous gases like H2S, CO and Methane willbe sensed and displayed each and every second in the web based application. If these gases exceed the normal level then an alarm is generated immediately and also an alert message (SMS) is sent tothe authorized person through the wifi.The advantage of this automated detection and alerting system over the manual method is that it offers quick response time and accurate detection of an emergency and in turn leading faster diffusion of the critical situation using gas purification process convert a toxic gases into pure air. The garbage alerting system is used to control the air pollution. All the gas sensor values are continuously monitoring through the mobile application using wifi module. This system is very much useful to make a city smart as well as reduce the human death.
On the Effectiveness of Regularization Against Membership Inference Attacks

Deep learning models often raise privacy concerns as they leak information about their training data. This enables an adversary to determine whether a data point was in a model's training set by conducting a membership inference attack (MIA). Prior work has conjectured that regularization techniques, which combat overfitting, may also mitigate the leakage. While many regularization mechanisms exist, their effectiveness against MIAs has not been studied systematically, and the resulting privacy properties are not well understood. We explore the lower bound for information leakage that practical attacks can achieve. First, we evaluate the effectiveness of 8 mechanisms in mitigating two recent MIAs, on three standard image classification tasks. We find that certain mechanisms, such as label smoothing, may inadvertently help MIAs. Second, we investigate the potential of improving the resilience to MIAs by combining complementary mechanisms. Finally, we quantify the opportunity of future MIAs to compromise privacy by designing a white-box `distance-to-confident' (DtC) metric, based on adversarial sample crafting. Our metric reveals that, even when existing MIAs fail, the training samples may remain distinguishable from test samples. This suggests that regularization mechanisms can provide a false sense of privacy, even when they appear effective against existing MIAs.
Determination and Quantification of Schistosoma mansoni Cercarial Emergence from Biomphalaria glabrata Snails

Abstract: Living and fixed samples of Schistosoma mansoni–infected Biomphalaria glabrata snails were used to determine the relative contributions of different snail tissues to cercarial emergence (shedding). Three methods of observations were employed: (1) direct microscopical observations of shedding snails; (2) microscopic analysis of 5 μm serial sections (H&E stained) of actively shedding snails; and (3) scanning electron microscopic (SEM) observations of snails that were fixed while actively shedding. For this investigation, there were advantages and disadvantages to using each method. We confirmed the results of others that there were 3 tissues of the snail that contributed most prominently to cercarial release (mantle collar, pseudobranch, and headfoot). Based on histological analysis of cercarial accumulations in presumed shedding sites in these 3 tissues, 57% of the cercariae could be seen in the mantle collar, 30.6% in the pseudobranch, and 12.5% in the headfoot. Other anterior structures were involved to a much lesser extent. SEM observations clearly showed cercariae emerging either body first, tail first, or likely emerging en masse from blebs, especially from the mantle collar. These studies provide a more quantitative appraisal of the role the different anterior snail tissues play in cercarial emergence.