Miracle-dz/UniFAR-FTUs huggingface dataset:
Scheduling Optimization of Home Health Care Service Considering Patients’ Priorities and Time Windows

As a new service model, home health care can provide effective health care by adopting door-to-door service. The reasonable arrangements for nurses and their routes not only can reduce medical expenses, but also can enhance patient satisfaction. This research focuses on the home health care scheduling optimization problem with known demands and service capabilities. Aimed at minimizing the total cost, an integer programming model was built in this study, which took both the priorities of patients and constraints of time windows into consideration. The genetic algorithm with local search was used to solve the proposed model. Finally, a case study of Shanghai, China, was conducted for the empirical analysis. The comparison results verify the effectiveness of the proposed model and methodology, which can provide the decision support for medical administrators of home health care.
Automated Storytelling Evaluation and Story Chain Generation

Given a beginning and ending document, automated storytelling attempts to fill in intermediary documents to form a coherent story. This is a common problem for analysts; they often have two snippets of information and want to find the other pieces that relate them. Evaluation of the quality of the created stories is difficult and has routinely involved human judgment. This work extends the state of the art by providing quantitative methods of story quality evaluation which are shown to have good agreement with human judgment. Two methods of automated storytelling evaluation, dispersion and coherence are developed. Dispersion, a measure of story flow, ascertains how well the generated story flows away from the beginning document and towards the ending document. Coherence measures how well the articles in the middle of the story provide information about the relationship of the beginning and ending document pair. Kullback-Leibler divergence (KLD) is used to measure the ability to encode the vocabulary of the beginning and ending story documents using the set of middle documents in the story. The dispersion and coherence methodologies developed here have the added benefit that they do not require parametrization or user inputs and are also easily automated. An automated storytelling algorithm is proposed as a multicriteria optimization problem that maximizes dispersion and coherence simultaneously. The developed storytelling methodologies will allow for the automated identification of information which associates disparate documents in support of literaturebased discovery and link analysis tasking. In addition, the methods provide quantitative measures of the strength of these associations.
Characterization of Chitinase Genes from an Alkaliphilic Actinomycete, Nocardiopsis prasina OPC-131

ABSTRACT An alkaliphilic actinomycete, Nocardiopsisprasina OPC-131, secretes chitinases, ChiA, ChiB, and ChiBΔ, in the presence of chitin. The genes encoding ChiA and ChiB were cloned and sequenced. The open reading frame (ORF) of chiA encoded a protein of 336 amino acids with a calculated molecular mass of 35,257 Da. ChiA consisted of only a catalytic domain and showed a significant homology with family 18 chitinases. The chiB ORF encoded a protein of 296 amino acids with a calculated molecular mass of 31,500 Da. ChiB is a modular enzyme consisting of a chitin-binding domain type 3 (ChtBD type 3) and a catalytic domain. The catalytic domain of ChiB showed significant similarity to Streptomyces family 19 chitinases. ChiBΔ was the truncated form of ChiB lacking ChtBD type 3. Expression plasmids coding for ChiA, ChiB, and ChiBΔ were constructed to investigate the biochemical properties of these recombinant proteins. These enzymes showed pHs and temperature optima similar to those of native enzymes. ChiB showed more efficient hydrolysis of chitin and stronger antifungal activity than ChiBΔ, indicating that the ChtBD type 3 of ChiB plays an important role in the efficient hydrolysis of chitin and in antifungal activity. Furthermore, the finding of family 19 chitinase in N.prasina OPC-131 suggests that family 19 chitinases are distributed widely in actinomycetes other than the genus Streptomyces.
A Case of Galactosaemia with Special Reference to Mental Development

Galactosaemia was originally described by von Reuss in 1908 and since then a number of cases have been reported. From a study of these a fairly characteristic picture is presented, the most constant features being failure to thrive, hepatomegaly, galactosua and albuminuria. Other less constant features are mental retardation, jaundice, vomiting, cataract, pyrexia, diarrhoea and a tendency to bleed. From a description of reported cases the disease appears to vary considerably in its severity. Some patients die in early infancy and, judging from retrospective studies, perhaps some die undiagnosed. Other cases appear to be kss severe and may not be diagnosed for several months. One patient reported by Donnell and Lann (1951) was not diagnosed for 13 months though he had had 'nutramigen' for a period. Bray, Isaac and Watkins (1952) report a case diagnosed at 7 years. With treatment by excluding lactose from the diet many of the clinical features, such as galactosuria and hepatomegaly, disappear and the patients show rapid improvement in physical development. Fox, Fyfe and Mollison (1954) suggest that if therapy is begun early the manifestations of the disease may be reversible, but if delayed, prognosis is poor. The purpose of this paper is to record the clinical picture and development of a severe case diagnosed in early infancy and kept on a lactose-free diet except for the first month, at which time the diagnosis was presumed, and a period of 14 days when the child was transferred to University Colkge Hospital under Dr. C. E. Dent for confirmation of the diagnosis and for reassessment of his tolerance to galactose. During this latter period the mechanism of amino-aciduria was investigated, and the results of this investigation are presented by Cusworth, Dent and Flynn in the following paper.
The genetic diversity of Mycobacterium tuberculosis strains in Thailand studied by amplification of DNA segments containing direct repetitive sequences.

OBJECTIVE To develop and use a polymerase chain reaction (PCR) method for studying the genetic diversity of Mycobacterium tuberculosis. DESIGN Two polymorphic DNA segments of M. tuberculosis H37Rv were identified and sequenced. Primers were then designed for simultaneous amplification of both polymorphic segments. The method was used for studying 179 clinical isolates of M. tuberculosis that had been previously characterized by Southern hybridization with IS6110. RESULTS Both polymorphic segments contained direct repetitive sequences. In one segment the direct repetitive sequences were within the putative coding sequence of alpha-isopropylmalate synthase gene. After amplifying both segments of the 179 isolates, 40 patterns of PCR products could be identified. The method was able to differentiate 38 IS6110-single-banded isolates into 23 types. Most of the isolates belonging to the Beijing family had PCR products identical to the H37Rv strain. The PCR products of the members of the Nonthaburi group were similar to each other. CONCLUSION These results agree with the hypothesis that the members of the Beijing family and the Nonthaburi group descended from two common ancestors. The PCR method might be useful for differentiating strains of M. tuberculosis that contain a single copy of IS6110.
ACOUSTIC SPEECH RECOGNITION FOR MARATHI LANGUAGE USING SPHINX

Speech recognition or speech to text processing, is a process of recognizing human speech by the computer and converting into text. In speech recognition, transcripts are created by taking recordings of speech as audio and their text transcriptions. Speech based applications which include Natural Language Processing (NLP) techniques are popular and an active area of research. Input to such applications is in natural language and output is obtained in natural language. Speech recognition mostly revolves around three approaches namely Acoustic phonetic approach, Pattern recognition approach and Artificial intelligence approach. Creation of acoustic model requires a large database of speech and training algorithms. The output of an ASR system is recognition and translation of spoken language into text by computers and computerized devices. ASR today finds enormous application in tasks that require human machine interfaces like, voice dialing, and etc. Our key contribution in this paper is to create corpora for Marathi language and explore the use of Sphinx engine for automatic speech recognition.
Datos, técnicas y resultados del moderno análisis económico regional: Proyecto Hispalink : Jornadas Hispalink (8ª. 1992. Valencia)

El Proyecto HISPALINK constituye una linea de investigacion en economia aplicada de un conjunto de universidades espanolas. Su objetivo es la revision y mejora permanente del analisis de la situacion actual y perspectivas economicas de las regiones espanolas. Para alcanzar tales objetivos, cada equipo ha desarrollado un modelo econometrico que trata de describir aproximadamente el comportamiento de la region correspondiente. El conjunto de equipos dispone de una base de datos comun Hispadat que se elabora a partir de la informacion de la Contabilidad Regional de Espana, utiliza las mismas predicciones iniciales para el conjunto de la economia espanola y coordina las predicciones regionales a traves de un Modelo de congruencia. Los resultados del Proyecto HISPALINK se ponen a disposicion de la sociedad espanola a traves de las instituciones nacionales y regionales que patrocinan el proyecto Un resumen del analisis realizado se presenta publicamente dos veces al ano en las Jornadas Hispalink correspondientes.
The Web-based Subjective Quality Assessment of an Adaptive Image Compression Plug-in

Images are a key element for conveying information about visual systems. However, image-based representation and communication require large information bandwidth. Image compression is currently the leading methodology for reducing bandwidth/load problems thus improving User Experience. Synthetic objective metrics are often used to assess the quality of image compression models, but they often do not reliably predict subjective ratings. This work shows the end-users’ quality evaluation of a new compression plug-in fully compliant with all on-going image formats. The subjective quality assessment of jpeg pictures compressed by the plug-in followed a new Web-based Single Stimulus Continuous Quality Scale method, whose validity and reliability have been described in a previously published study. The results of this study show that pictures compressed by the proposed adaptive image compression plug-in have a 55% compression gain compared to jpeg images compressed by Facebook Mobile, with no loss in perceived
Effects of Metoclopramide on Healing of Colonic Anastomoses in a Rat Model of Abdominal Sepsis

ABSTRACT Introduction: Metoclopramide is often used in the treatment of postoperative nausea and vomiting, but a literature review failed to find reports on the influence of this drug on the healing of bowel anastomoses in the setting of abdominal sepsis. The aim of this study was to evaluate the effects of metoclopramide on the healing of left colonic anastomoses in rats with induced abdominal sepsis. Materials and Methods: Forty rats were divided into two groups of 20 animals each to receive either metoclopramide (experimental group: E) or saline (control group: C). Each group was further divided into subgroups of 10 animals each to be killed on the third (E3 and C3) or seventh postoperative day (E7 and C7). A segmental resection of the left colon was performed, followed by end-to-end anastomosis. Sepsis was induced by cecal ligation and puncture. On the day of reoperation, the total number of adhesions was assessed and the anastomosed bowel segment was removed for tensile strength testing, histopathological analysis, measurement of hydroxyproline levels, and histomorphometric evaluation of collagen. Results: Intraoperative findings, number of intra-abdominal adhesions in the anastomosed area, and tensile strength before anastomosis rupture were similar among all subgroups at all assessments. On the third postoperative day, the anastomoses of animals treated with metoclopramide showed significantly lower hydroxyproline levels (p = 0.01) when compared with controls. Collagen content was similar among all subgroups. Conclusions: Metoclopramide does not have deleterious effects on the healing of bowel anastomoses in rats subjected to experimental abdominal sepsis.
A New Acycloguanosine-Specific Supermutant of Herpes Simplex Virus Type 1 Thymidine Kinase Suitable for PET Imaging and Suicide Gene Therapy for Potential Use in Patients Treated with Pyrimidine-Based Cytotoxic Drugs

The herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene is widely used as a suicide gene in combination with ganciclovir (GCV) and as a nuclear imaging reporter gene with an appropriate reporter probe. Wild-type HSV1-tk recognizes a variety of pyrimidine and acycloguanosine nucleoside analogs, including clinically used antiviral drugs. PET of HSV1-tk reporter gene expression will be compromised in patients receiving nucleoside-based antiviral treatment. With the use of an acycloguanosine-specific mutant of the enzyme, PET of HSV1-tk reporter gene expression can be successfully performed with acycloguanosine-based radiotracers without interference from pyrimidine-based antiviral drugs. Methods: The levels of expression of wild-type HSV1-tk and HSV1-A167Ytk, HSV1-sr39tk, and HSV1-A167Ysr39tk mutants fused with green fluorescent protein (GFP) and transduced into U87 cells were normalized to the mean fluorescence of GFP measured by fluorescence-activated cell sorting. The levels of enzymatic activities of wild-type HSV1-tk and its mutants were compared by 2-h in vitro radiotracer uptake assays with 3H-2′-fluoro-2′-deoxy-1-β-d-arabinofuranosyl-5-ethyluracil (3H-FEAU), 3H-pencyclovir (3H-PCV), and 3H-GCV and by drug sensitivity assays. PET with 18F-FEAU and 18F-9-[4-fluoro-3-(hydroxymethyl)butyl]guanine (18F-FHBG) was performed in mice with established subcutaneous tumors, expressing wild-type HSV1-tk and its mutants, followed by tissue sampling. Results: FEAU accumulation was not detected in HSV1-A167Ysr39tk–expressing cells and xenografts. Lack of conversion of pyrimidine derivatives by the HSV1-A167Ysr39tk supermutant was also confirmed by a drug sensitivity assay, in which the 50% inhibitory concentrations for thymine 1-β-d-arabinofuranoside and bromovinyldeoxyuridine were found to be similar to those in nontransduced cells. In contrast, we found that HSV1-A167Ysr39tk could readily phosphorylate 3H-GCV at levels similar to those of wild-type HSV1-tk and HSV1-A167Ytk but showed enhanced activity with 3H-PCV in vitro and with 18F-FHBG in vivo. Conclusion: We developed a new reporter gene, HSV1-A167Ysr39tk, which exhibits specificity and high phosphorylation activity for acycloguanosine derivatives. The resulting supermutant can be used for PET with 18F-FHBG and suicidal gene therapy protocols with GCV in patients treated with pyrimidine-based cytotoxic drugs.
XAS speciation of arsenic in a hyper-accumulating fern.

The coordination environment and the redox speciation of arsenic in a newly discovered arsenic hyper-accumulating fern (Pteris vittata L) were investigated by X-ray absorption spectroscopy. This method allowed us to probe arsenic directly, i.e., with minimal sample preparation. The results indicate that arsenic is predominantly accumulated as As(III) in the leaves. XANES and EXAFS results show that As(III) in the leaves is primarily present as aqueous arsenite species. The plant actively maintains arsenic in this reduced oxidation state, because after sample collection and subsequent aging and drying of the plant material, As(III) is gradually oxidized to As(V). We think that these arsenite species are sequestered in vacuoles. At extremely high As concentrations (ca. 1% As per dry weight) arsenic in the fern leaves is coordinated to a significant degree by sulfur in addition to oxygen. This spectral signature indicates that thiol-rich compounds are implicated in the biochemical transformations of arsenic within the plant.
Close the Gaps: A Learning-While-Doing Algorithm for Single-Product Revenue Management Problems

We consider a retailer selling a single product with limited on-hand inventory over a finite selling season. Customer demand arrives according to a Poisson process, the rate of which is influenced by a single action taken by the retailer such as price adjustment, sales commission, advertisement intensity, etc. The relationship between the action and the demand rate is not known in advance. However, the retailer is able to learn the optimal action on the fly as she maximizes her total expected revenue based on the observed demand reactions. Using the pricing problem as an example, we propose a dynamic learning-while-doing algorithm that only involves function value estimation to achieve a near-optimal performance. Our algorithm employs a series of shrinking price intervals and iteratively tests prices within that interval using a set of carefully chosen parameters. We prove that the performance of our algorithm is among the best of all possible algorithms in terms of the asymptotic regret the relative loss compared to the full information optimal solution. Our result closes the performance gaps between parametric and nonparametric learning and between the post-price mechanism and the customer-bidding mechanism. Important managerial insight from this research is that the values of information on both the parametric form of the demand function as well as each customer's exact reservation price are less important than prior literature suggests. Our results also suggest that firms would be better off to perform dynamic learning and action concurrently rather than sequentially.
The Columbia anthology of modern Chinese drama

AcknowledgmentsIntroduction1. Hu Shi, The Main Event in Life (1919), translated by Edward M. Gunn2. Hong Shen, Yama Zhao (1922), translated by Carolyn T. Brown3. Tian Han, The Night the Tiger Was Caught (1922-1923), translated by Jonathan S. Noble4. Ouyang Yuqian, After Returning Home (1922), translated by Jonathan S. Noble5. Ding Xilin, A Wasp (1923), translated by John B. Weinstein and Carsey Yee6. Ding Xilin, Oppression (1925), translated by John B. Weinstein and Carsey Yee7. Bai Wei, Breaking Out of Ghost Pagoda (1928), translated by Paul B. Foster8. Cao Yu, Thunderstorm (1934), translated by Wang Tso-liang and A. C. Barnes, revised translation by Charles Qianzhi Wu, with a translation of prologue and epilogue9. Li Jianwu, It's Only Spring (1934), translated by Tony Hyder10. Xia Yan, Under Shanghai Eaves (1937), translated by George Hayden11. Wu Zuguang, Return on a Snowy Night (1942), translated by Thomas Moran12. Lao She, Teahouse (1958), translated by Ying Ruocheng, revised by Claire Conceison13. Tian Han, Guan Hanqing (1958), retranslated by Amy Dooling14. Chen Yun, The Young Generation (1965), translated by Constantine Tung and Kevin A. O'Connor15. Weng Ouhong and A Jia, revised by the China Peking Opera Troupe, The Red Lantern (1970), translated by Brenda Austin and John B. Weinstein16. Gao Xingjian, The Bus Stop (1983), translated by Shiao-Ling Yu17. Li Longyun, Wilderness and Man (1988), translated by Bai Di and Nick Kaldis18. Yang Limin, Geologists (1995), translated by Timothy C. Wong19. Huang Jisu, Zhang Guangtian, and Shen Lin, Che Guevara (2000), translated by Jonathan S. Noble20. Stan Lai (Lai Sheng-chuan), in collaboration with the cast, Secret Love in Peach Blossom Land (1986), translated by Stan Lai21. Anthony Chan, Metamorphosis Under the Star (1986), translated by Grace Liu and Julia Wan22. Joanna Chan, Crown Ourselves with Roses (1988), written and translated by Joanna ChanGlossaryContributors
Making Sense of Globalization

Francois Bourguignon, DELTA, Paris Diane Coyle, Enlightenment Economics Raquel Fernandez, New York University and CEPR Francesco Giavazzi, IGIER, Universita Bocconi, Milano and CEPR Dalia Marin, Universitat Munchen and CEPR Kevin O’Rourke, Trinity College, Dublin and CEPR Richard Portes, London Business School and CEPR Paul Seabright, Universite des Sciences Sociales de Toulouse and CEPR Anthony Venables, London School of Economics and CEPR Thierry Verdier, DELTA, Paris and CEPR L. Alan Winters, University of Sussex and CEPR
A Physical-Layer Network Coding Scheme Based on Linear MIMO Detection

A physical-layer network coding (PNC) scheme based on MIMO linear detection is proposed in this paper for a two-way relay channel with a multi-antenna relay. We apply a real-valued linear combiner to the output symbols of the MIMO linear detector to obtain a superimposed constellation for which the labelling is obtained from the exclusive or operation on the two transmitted symbols. The superimposed constellation is QAM-like which can facilitate the SER (symbol error rate) analysis.
The mystery of chromosomal translocations in cancer

Chromosomal translocations in human cancer may result in products that can be suppressed by targeting drugs. An example is bcr-abl tyrosine kinase in chronic myelogenous leukemia that can be treated with imatinib mesylate. However, the mechanisms of translocations or exchanges of chromosomal segments are virtually unknown. In this summary, chromosomal translocations in human cancer are compared with ‘crossing over’ of chromosomal segments occurring during the first meiotic division. Several proposed mechanisms of the exchange of DNA between and among chromosomes are discussed. The conditions that appear essential for these events to occur are listed. Among them are proximity of the involved DNA segments, mechanisms of excising the target DNA, its transport to the new location, and integration into the pre-existing chromosome. The conclusion based on extensive review of the literature is that practically nothing is known about the mechanism of ‘crossing over’ or translocation. Based on prior work on normal human cells, it is suggested that only one of the two autosomes participates in these events that may include loss of heterozygozity, another common abnormality in human cancer.
OpenML Benchmarking Suites and the OpenML100

We advocate the use of curated, comprehensive benchmark suites of machine learning datasets, backed by standardized OpenML-based interfaces and complementary software toolkits written in Python, Java and R. Major distinguishing features of OpenML benchmark suites are (a) ease of use through standardized data formats, APIs, and existing client libraries; (b) machine-readable meta-information regarding the contents of the suite; and (c) online sharing of results, enabling large scale comparisons. As a first such suite, we propose the OpenML100, a machine learning benchmark suite of 100~classification datasets carefully curated from the thousands of datasets available on OpenML.org.
Estimation of the under-reporting rate for the surveillance of Escherichia coli O157[ratio ]H7 cases in Ontario, Canada

Two models estimating the proportion of Escherichia coli O157[ratio ]H7 cases not reported in the Ontario notifiable diseases surveillance system are described. The first model is a linear series of adjustments in which the total number of reported cases is corrected by successive under-reporting coefficients. The structure of the second model is based on a relative difference in the proportion of E. coli O157[ratio ]H7 cases which are hospitalized between the surveillance database and the underlying population. Based on this analysis, the rate of under-reporting of symptomatic cases of E. coli O157[ratio ]H7 infection in Ontario ranges from 78 to 88% corresponding to a ratio of 1 reported case for approximately 4–8 symptomatic cases missed by the surveillance system. This study highlights the need to increase awareness among public health workers of the potential biases that may exist in the interpretation of routine surveillance data.