Miracle-dz/UniFAR-FTUs huggingface dataset:
Mesenchymal Stem Cells Acquire Characteristics of Cells in the Periodontal Ligament in vitro

Mesenchymal stem cells differentiate into multiple types of cells derived from mesenchyme. Periodontal ligament cells are primarily derived from mesenchyme; thus, we expected mesenchymal stem cells to differentiate into periodontal ligament. Using a combination of immunohistochemistry and in situ hybridization on co-cultures of mesenchymal stem cells and periodontal ligament, we observed a significant increase in mesenchymal stem cells’ expression of osteocalcin and osteopontin and a significant decrease in expression of bone sialoprotein, characteristics of periodontal ligament in vivo. Increased osteopontin and osteocalcin and decreased bone sialoprotein expression was detected within 7 days and maintained through 21 days of co-culture. We conclude that contact or factors from periodontal ligament induced mesenchymal stem cells to obtain periodontal-ligament-like characteristics. Importantly, analysis of the data suggests the feasibility of utilizing mesenchymal stem cells in clinical applications for repairing and/or regenerating periodontal tissue.
The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy: a randomized controlled trial

Background High blood pressure (BP) significantly increases overall cardiovascular risk, the incidence of ischemic heart disease and stroke. One of the most important causes of insufficient BP control is low treatment compliance. Reminders and electronic compliance monitoring have been shown to be effective in improving patient compliance to some extent, but the combined effect has not been documented. Objective To assess the impact of an electronic reminder and monitoring device on patient compliance and BP control. Methods All patients received medical treatment with telmisartan once daily and were randomized to either electronic compliance monitoring with a reminder and monitoring device or standard therapy for 6 months. Both groups were crossed over after 6 months. Intervention effectiveness was assessed using self-reported compliance and BP. Results Data from 398 patients were analysed. In the first half of the study, patients using the device reported 91% compliance versus 85% in the control group. This difference diminished after crossover (88 versus 86%). BP was not affected. Electronic monitoring data on compliance revealed taking, dosing and timing compliance between 45 and 52% in study group 1, and between 32 and 38% in study group 2. Conclusion The Helping Hand reminder device was most suitable if used for newly diagnosed hypertensive patients, when it improved compliance by 6%. With the present medical treatment, the device does not have any influence on BP control, but with less forgiving medications, the device might make a significant difference. The use of the device can be an easy and effective way to improve compliance in selected patients.
Study on artificial stock market model based on heterogeneous investors

By depicting trade strategy imitation among investors and stock price forming mechanism, we establish an artificial stock market model based on heterogeneous investors with the method of mean field approximation. The model considers both behavioral heterogeneity of investors and structural heterogeneity of investor network. The simulation results reveal that in certain parameter interval, the stock return of artificial market has the same properties as that of real markets, such as volatility clustering, sharp peaks and thick tail distributions, nonlinear time correlation. The investors' trade strategy imitation tendency and the network average degree have positive relations with return fluctuation level. The trade behaviors of fundamentalists can smooth stock price fluctuations. Thus, fostering institutional investors will favor the steady development of stock market.
Accuracy of HMM-based phonetic segmentation using monophone or triphone acoustic model

The paper compares the accuracy of HMM-based automatic phonetic segmentation using various signal representation same as acoustic models of various complexity, i.e. acoustic models of monophones or word-internal triphones with various number of mixtures. The precision of automatic phonetic segmentation was measured on the basis of comparison with manually segmented speech data. The analysis showed that the segmentation with acoustic models of word-internal tri-phones yielded to a better target accuracy. The best results of automatic phonetic segmentation were attained for acoustic models of word-internal triphones with four mixtures. In this case average values of shift of phone boundaries and change of phone length was about 5.9 ms and 0.2 ms respectively.
Malnutrition is the cause of the majority of deaths in children under five years old in Ethiopia

Malnutrition is the cause of the majority of deaths in children under five years old in Ethiopia. Micronutrient deficiencies such as iron, zinc and calcium, often seen in malnourished children, are major public health problems throughout Ethiopia. These deficiencies have negative consequences on the cognitive and physical development of children, and on work productivity of adults. There is, therefore, a need for sustainable methods to address iron inadequacy in complementary feeding. Animal products are a good source of iron, zinc and calcium, but due to their high costs, their consumption by most children in Ethiopia has declined. The grain amaranth grows wild in areas of Ethiopia but is considered a weed. This study, conducted in rural Ethiopia, was initiated to prepare nutrient-rich complementary food using recipes that substituted the usual maize gruel with porridge made from amaranth and chickpea flours. Using a laboratory based experimental study design, four porridges suitable for complementary feeding, with different proportions of amaranth grains, maize and chickpeas were formulated in triplicate and analyzed in triplicate for minerals including iron, and phytate levels. Mother-child pairs were recruited for acceptability testing, at the community level. Results showed adding amaranth improved the content of iron and other nutrients as compared to control porridge (100% maize) and decreased phytate levels. The lowest phytate to iron ratio (0.24) was observed in the 70% amaranth and 30% chickpea blend, and the lowest viscosity measure was also observed in this same formulation. Soaking amaranth seeds in warm (50oC) water then germinating in lemon juice-containing water at 32oC for 72 hours resulted in the lowest phytate levels. In sensory testing, all of the formulated porridges with different proportions of amaranth flour were acceptable to mothers and their children, although the red color was disliked by mothers and their children. Flavor preference was not altered; however, overall acceptability was reduced with increasing amounts of amaranth. The study indicated that a processed 70% amaranth and 30% chickpea product can be used to produce low-cost, nutrient-rich complementary food with moderate acceptability. Increased nutritional awareness, production and consumption of grain amaranth products may be the way to address mineral deficiencies including iron, in the study area.
Multiinput Direct DC–AC Converter With High-Frequency Link for Clean Power-Generation Systems

This paper proposes a new topology for bidirectional multiinput direct dc-ac converter for clean-power-generation system, therefore, at the input port, a boost converter is used to meet the requirement of many distributed generation systems, such as photovoltaic, and fuel cell systems. The boost converter can increase the dc input voltage. This point results in a turn ratio reduction of high-frequency isolating link transformer. Furthermore, the boost inductor reduces the input current ripple, therefore, the saturation of the transformer can be avoided for higher output currents. The count of used devices has been reduced in the proposed converter. As a result, the cost, size, and the volume of the converter can be reduced. The reduced conversion steps increase the efficiency of the converter. The converter is analyzed step by step to show the principles of the operation in providing energy management based on duty-cycle variations. The system capability in different operation conditions has been simulated, and the simulation results have been compared with measurement results. Dynamic analysis and control design of the bidirectional dc-ac converter is presented based on nonlinear control by input-output feedback linearization.
Design of microstrip slot antenna for WiMAX application

In this paper, a compact microstrip patch antenna has a slit associated with the slot at the edge of the radiator which is known as slot antenna for WiMAX application is presented. Instead of semi-infinite ground plane, the proposed antenna adopts the partial ground plane. Radiating patch lies on the Rogers Duroid 5880 substrate which is having low dielectric constant, thereby provides good bandwidth. Microstrip feedline technique is used to feed the antenna with 50Ω impedance. WiMAX (Worldwide Interoperability for Microwave Access) has three frequency bands. The lower band (2.5-2.69 GHz), the middle band (3.2-3.6 GHz), and the upper band (5.2-5.8 GHz). This proposed antenna enhances the return loss to -16.5 dB at the lower and middle frequency range of WiMAX application. Computer simulated results showing the VSWR value lesser than two in the lower and middle frequency range of WiMAX enhances the adoption of this antenna for WiMAX application in both lower and middle bands.
Insight into Selectivity of Peptidomimetic Inhibitors with Modified Statine Core for Plasmepsin II of Plasmodium falciparum over Human Cathepsin D

Plasmepsin II (PlmII), an aspartic protease expressed in the food vacuole of Plasmodium falciparum (pf), cleaves the hemoglobin of the host during the erythrocytic stage of the parasite life cycle. Various peptidomimetic inhibitors of PlmII reported so far discriminate poorly between the drug target and aspartic proteases of the host organism, e.g., human cathepsin D (hCatD). hCatD is a protein digestion enzyme and signaling molecule involved in a variety of physiological processes; therefore, inhibition of hCatD by PlmII inhibitors may lead to pathophysiological conditions. In this study, binding of PlmII inhibitors has been modeled using the crystal structures of pfPlmII and hCatD complexes to gain insight into structural requirements underlying the target selectivity. A series of 26 inhibitors were modeled in the binding clefts of the pfPlmII and hCatD to establish QSAR models of the protease inhibition. In addition, 3D‐QSAR pharmacophore models were generated for each enzyme. It was concluded that the contributions of the P2 and P3′ residues to the inhibitor’s binding affinity are responsible for the target selectivity. Based on these findings, new inhibitor candidates were designed with predicted inhibition constants reaching 0.2 nm and selectivity index (S.I.) = > 1200.
Metabolic Rate and Prehibernation Fattening in Free-Living Arctic Ground Squirrels

Hibernating mammals become sequestered and cease foraging during prolonged seasonal periods of reduced or unpredictable food availability and instead rely on cached food and/or endogenous reserves of fat and protein accumulated during the previous active season. The gain in weight is due to increased food consumption, but it also has been hypothesized that hibernators maximize rates of fattening by decreasing costs of maintenance before weight gain, reflected in reduced resting metabolic rate (RMR). We recorded repeated measures of total body, lean, and fat mass in individual adult male and female arctic ground squirrels across their active season and found that squirrels increased body mass by 42% (males) and 62% (females). This gain was achieved through a 17% increase in lean mass and a 7–8-fold increase in fat mass; however, mass gain was not linear and patterns differed between sexes. Contrary to our hypothesis, decreases in RMR were not associated with rapid mass gain. We found RMR of males increased (whole-animal RMR or lean-mass-specific RMR) or remained constant (mass-specific RMR) for most of the active season and decreased only after the majority of mass had been gained. In females, although RMR (whole-animal, mass-specific, and lean-mass RMR) generally decreased across the active season, the greatest decrease occurred late in the active season after the majority of mass had been gained. In conclusion, arctic ground squirrels do not trade off metabolism to facilitate rates of weight gain before hibernation, but they do use energy sparing strategies before hibernation that help maintain peak mass.
The protective influence of saffron and selenium on oxidant disturbances in brai

(ACR) is an industrial neurotoxic chemical that has been -rich foods cooked at high temperature. in acrylamide-induced neurotoxicity. Seven seven groups served as control group, groups treated selenium (0.04 mg/kg), saffron 30mg/kg, and Acrylamide (50 mg/kg) for 8 days, and groups before and Only weak and transient DNA damage was recorded in the brain The treatment in combination of saffron
Rotman lens recent developments 1994-2005

Accurate Rotman lens (Rotman, W. and Turner, R.F., 1962) analysis must include computing the full scattering matrix of the lens, including mutual coupling between the feed ports and internal reflections. Options to include the most common lens feed port and substrate configurations are also required for maximum utility. Because of the large electrical area of the lens (typically >100 square wavelengths), analysis using completely rigorous methods, such as MoM, FE or FDTD, may not be feasible. Three methods for solving the problem are described and results are summarized. A recent application utilizing 2D Rotman lens stack beamformers for SHF and EHF commercial SATCOM and MILSATCOM applications is summarized.
Visual Pose Estimation of Rescue Unmanned Surface Vehicle From Unmanned Aerial System

This article addresses the problem of how to visually estimate the pose of a rescue unmanned surface vehicle (USV) using an unmanned aerial system (UAS) in marine mass casualty events. A UAS visually navigating the USV can help solve problems with teleoperation and manpower requirements. The solution has to estimate full pose (both position and orientation) and has to work in an outdoor environment from oblique view angle (up to 85° from nadir) at large distances (180 m) in real-time (5 Hz) and assume both moving UAS (up to 22 m s−1) and moving object (up to 10 m s−1). None of the 58 reviewed studies satisfied all those requirements. This article presents two algorithms for visual position estimation using the object's hue (thresholding and histogramming) and four techniques for visual orientation estimation using the object's shape while satisfying those requirements. Four physical experiments were performed to validate the feasibility and compare the thresholding and histogramming algorithms. The histogramming had statistically significantly lower position estimation error compared to thresholding for all four trials (p-value ranged from ~0 to 8.23263 × 10−29), but it only had statistically significantly lower orientation estimation error for two of the trials (p-values 3.51852 × 10−39 and 1.32762 × 10−46). The mean position estimation error ranged from 7 to 43 px while the mean orientation estimation error ranged from 0.134 to 0.480 rad. The histogramming algorithm demonstrated feasibility for variations in environmental conditions and physical settings while requiring fewer parameters than thresholding. However, three problems were identified. The orientation estimation error was quite large for both algorithms, both algorithms required manual tuning before each trial, and both algorithms were not robust enough to recover from significant changes in illumination conditions. To reduce the orientation estimation error, inverse perspective warping will be necessary to reduce the perspective distortion. To eliminate the necessity for tuning and increase the robustness, a machine learning approach to pose estimation might ultimately be a better solution.
cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects

We have identified unique chemical and biological properties of a cationic monofunctional platinum(II) complex, cis-diammine(pyridine)chloroplatinum(II), cis-[Pt(NH3)2(py)Cl]+ or cDPCP, a coordination compound previously identified to have significant anticancer activity in a mouse tumor model. This compound is an excellent substrate for organic cation transporters 1 and 2, also designated SLC22A1 and SLC22A2, respectively. These transporters are abundantly expressed in human colorectal cancers, where they mediate uptake of oxaliplatin, cis-[Pt(DACH)(oxalate)] (DACH = trans-R,R-1,2-diaminocyclohexane), an FDA-approved first-line therapy for colorectal cancer. Unlike oxaliplatin, however, cDPCP binds DNA monofunctionally, as revealed by an x-ray crystal structure of cis-{Pt(NH3)2(py)}2+ bound to the N7 atom of a single guanosine residue in a DNA dodecamer duplex. Although the quaternary structure resembles that of B-form DNA, there is a base-pair step to the 5′ side of the Pt adduct with abnormally large shift and slide values, features characteristic of cisplatin intrastrand cross-links. cDPCP effectively blocks transcription from DNA templates carrying adducts of the complex, unlike DNA lesions of other monofunctional platinum(II) compounds like {Pt(dien)}2+. cDPCP–DNA adducts are removed by the nucleotide excision repair apparatus, albeit much less efficiently than bifunctional platinum–DNA intrastrand cross-links. These exceptional characteristics indicate that cDPCP and related complexes merit consideration as therapeutic options for treating colorectal and other cancers bearing appropriate cation transporters.
Effect of coherent crosstalk on optical OFDM transmission

We investigate the effect of reflection-generated coherent crosstalk on the performance of optical OFDM transmission. From simulation, allowable total crosstalk at a given OSNR was found to be independent of the number of subcarriers. Experimental comparison is provided, showing a similar crosstalk-generated variance for optical OFDM and NRZ-OOK format.
Study on main magnetic field of ultra-high voltage magnetically controlled saturated reactor

Reactive power compensation using controlled reactor in Ultra-High Voltage Transmission Lines not only can smoothly regulate system reactive power and realize flexible power transmission, but also can restrain power frequency operating over-voltage, reduce line losses, and improve system stability and safety greatly. According to the principle of controlled reactor, the controlled reactor works under the interaction of alternating current and direct current, so the calculation of main magnetic field is extremely complicated. Now, we don't know the distribution of main magnetic field under different conditions very well. So the article greatly researches and simulates the distribution of main magnetic field. The article provides the control characteristic curve, which can describe the continuous and smooth regulation scheme of the controlled reactor. We can know the Ultra-High Voltage Magnetically Controlled Saturated Reactor meet the design requirements and verify the rationality of the design by the study on the control characteristic curve and the distribution of main magnetic field. So we can make a prototype for further study.
Identification of magnetic deposits in 2-D axisymmetric eddy current models via shape optimization

The non-destructive control of steam generators is an essential task for the safe and failure-free operation of nuclear power plants. Due to magnetite particles in the cooling water of the plants, a frequent source for failures are magnetic deposits in the cooling loop of steam generators. From eddy current signals measured inside a U-tube in the steam generator, we propose and analyze a regularized shap optimization algorithm to identify magnetic deposits outside the U-tube with either known or unknown physical properties. Motivated by the cylindrical geometry of the U-tubes we assume an axisymmetric problem setting, reducing Maxwell’s equations to a 2-D elliptic eddy current problem. The feasibility of the proposed algorithms is illustrated via numerical examples demonstrating in particular the stability of the method under noise.
Arm Paralysis After Routine Childhood Vaccinations: Application of Advanced Molecular Methods to the Causality Assessment of an Adverse Event After Immunization

Post-licensure surveillance for adverse events following immunizations (AEFI) can identify rare complications of vaccinations and rigorous vaccine adverse event causality assessments can help to identify possible causal relationships. We report the development of arm paralysis after varicella vaccination in a 1-year-old child. Paralysis was initially presumed to be due to vOka because of the temporal relationship between vaccination and onset of arm weakness; however, molecular studies identified wild-type varicella zoster virus VZV (WT-VZV) in the CSF, leading the authors to conclude that WT-VZV was the probable cause. This case illustrates the complexity of assessing AEFI causality, and the importance of careful and complete evaluations when determining the most likely cause of an AEFI.
Did the Pleistocene glaciations promote divergence? Tests of explicit refugial models in montane grasshopprers

There is a long‐standing debate over whether or not the Pleistocene glaciations promoted speciation. While some models predict that extensive mixing of populations during interglacial expansion would have inhibited divergence, others postulate that divergence among allopatric glacial refuges or founder events during recolonization of previously glaciated areas would have promoted differentiation. Using a combination of traditional and coalescent based population genetic approaches, this study finds that the glaciations did not inhibit divergence among populations of the grasshopper Melanoplus oregonensis. Instead, drift associated with recolonization of previously glaciated areas, as well as divergence among multiple allopatric glacial refugia, have both contributed to differentiation in this montane grasshopper from the ‘sky islands’ of the northern Rocky Mountains. Significant population structure was detected by phylogenetic and FST analyses, including significant FST values among individual pairs of sky‐island populations. In addition to clustering of haplotypes within populations, there is some evidence of regional phylogeographic structure, although none of the ‘regional groups’ form a monophyletic clade and there is a lack of concordance between the genealogical and geographical positions of some haplotypes. However, coalescent simulations confirm there is significant regional phylogeographic structure that most likely reflects divergence among multiple ancestral refugial populations, and indicate that it is very unlikely that the observed gene tree could have been produced by the fragmentation of a single widespread ancestral population. Thus, rather than inhibiting differentiation, the glaciations appear to have promoted population divergence in M. oregonensis, suggesting that they may have contributed to the radiation of Melanoplus species during the Pleistocene.