Miracle-dz/UniFAR-FTUs huggingface dataset:
The Use of Mass Spectrometry in Characterization of Bone Morphogenetic Proteins from Biological Samples

1.1 Bone morphogenetic proteins Bone morphogenetic proteins (BMPs) are family of growth factors. (Chen et al., 2004; Vukicevic & Sampath, 2008) Discovered in context of bone biology, today they are recognized as important signaling molecules in wide range of biological processes, such as vertebrate embryonic development (Hogan, 1996), mesenchymal stem cell differentiation (Vukicevic & Grgurevic, 2009), kidney fibrosis, and more. For the last years BMP-2 and BMP-7 are used as therapeutics in orthopedics, harnessing their regenerative potential as growth factors. From the onset of medicine scholars have been aware of the bone regenerative potential. In 1965. Urist was first to show that demineralized bone matrix (DBM) can induce bone growth if implanted into extraskeletal site. Active component from DBM was named bone morphogenetic protein by Urist & Strates (1971). Purification, cloning and sequencing of BMP was done almost 20 years later by Wozney et al. (1988). They showed that BMP is not a single protein but a family of growth factors. From introduction of the BMP term through cloning and sequencing of individual BMPs in late 1980s, scientific output in the field has constantly grown and has exceeded 1500 papers in 2010. (Figure 1) BMPs are part of transforming growth factor (TGF) superfamily of proteins. In humans TGFsuperfamily constitutes of 37 proteins. (Figure 2) Beside BMPs, TGFsuperfamily includes TGFproteins, inhibins (INH), growth/differentiation factors (GDF) and few others: artemin (ARTN), glial cell line-derived neurotrophic factor (GDNF), left-right determination factor 1 (LFTY1), LFTY2, muellerian-inhibiting factor (MIS), nodal homolog (NODAL), neurturin (NRTN) and persephin (PSPN). BMPs are functionally and structurally very conserved throughout animal kingdom. Their biological importance is reflected through functional and structural redundancy of different BMPs in single species. BMPs are translated as pre-propeptides. Signal peptide targets them for secretion out of cell. Prodomain is two thirds to four fifths of total peptide length and The Use of Mass Spectrometry in Characterization of Bone Morphogenetic Proteins from Biological Samples
JLK isocoumarin inhibitors: Selective γ‐secretase inhibitors that do not interfere with notch pathway in vitro or in vivo

γ‐Secretase activity is involved in the generation of Aβ and therefore likely contributes to the pathology of Alzheimer's disease. Blocking this activity was seen as a major therapeutic target to slow down or arrest Aβ‐related AD progression. This strategy seemed more doubtful when it was established that γ‐secretase also targets other substrates including Notch, a particularly important transmembrane protein involved in vital functions, at both embryonic and adulthood stages. We have described previously new non‐peptidic inhibitors able to selectively inhibit Aβ cellular production in vitro without altering Notch pathway. We show here that in vivo, these inhibitors do not alter the Notch pathway responsible for somitogenesis in the zebrafish embryo. In addition, we document further the selectivity of JLK inhibitors by showing that, unlike other described γ‐secretase inhibitors, these agents do not affect E‐cadherin processing. Finally, we establish that JLKs do not inhibit β‐site APP cleaving enzymes (BACE) 1 and BACE2, α‐secretase, the proteasome, and GSK3β kinase. Altogether, JLK inhibitors are the sole agents to date that are able to prevent Aβ production without triggering unwanted cleavages of other proteins. © 2003 Wiley‐Liss, Inc.
Mitoxantrone versus daunorubicin in induction-consolidation chemotherapy--the value of low-dose cytarabine for maintenance of remission, and an assessment of prognostic factors in acute myeloid leukemia in the elderly: final report. European Organization for the Research and Treatment of Cancer and 

PURPOSE AND METHODS Optimization of remission-induction and postremission therapy in elderly individuals with acute myeloid leukemia (AML) was the subject of a randomized study in patients older than 60 years. Remission-induction chemotherapy was compared between daunomycin (DNR) 30 mg/m2 on days 1, 2, and 3 versus mitoxantrone (MTZ) 8 mg/m2 on days 1, 2, and 3, both plus cytarabine (Ara-C) 100 mg/m2 on days 1 to 7. Following complete remission (CR), patients received one additional cycle of DNR or MTZ chemotherapy and were then eligible for a second randomization between eight cycles of low-dose (LD)-Ara-C 10 mg/m2 subcutaneously every 12 hours for 1 2 days every 6 weeks or no further treatment. RESULTS A total of 242 patients was randomized to DNR and 247 to MTZ. Median age of both study groups was 68 years. Secondary AML was documented in 26% and 25% of patients in either arm. The probability of attaining CR was greater (P = .069) with MTZ (47%) than with DNR (38%). Median duration of neutropenia was 19 (DNR) and 22 days (MTZ). The greater response rate to MTZ therapy correlated with reduced occurrence of chemotherapy resistance (32% v 47%, P = .001). With a median follow-up of 6 years, 5-year disease-free survival (DFS) is 8% in each arm. Overall survival estimates are not different between the groups (6% v 9% at 5 yrs). Poor performance status at diagnosis, high WBC count, older age, secondary AML, and presence of cytogenetic abnormalities all had an adverse impact on survival. Secondary AML and abnormal cytogenetics predicted for shorter duration of CR. Among complete responders, 74 assessable patients were assigned to Ara-C and 73 to no further therapy. Actuarial DFS was significantly longer (P = .006) for Ara-C-treated (13% [SE = 4.0%] at 5 years) versus nontreated patients (7% [SE = 3%]), but overall survival was similar (P = .29): 18% (SE = 4.6%) versus 15% (SE = 4.3%). Meta-analysis on the value of Ara-C postremission therapy confirms these results. CONCLUSION In previously untreated elderly patients with AML, MTZ induction therapy produces a slightly better CR rate than does a DNR-containing regimen, but it has no significant effect on remission duration and survival. Ara-C in maintenance may prolong DFS, but it did not improve survival.
Shiva Temple ? Mahadevi Varma Ganges Penis History of India Vedas Meera General knowledge Sex positions World War II Vishnu Mohammed Rafi Global warming Sexual intercourse Mohandas Karamchand Gandhi Pollution Vagina Mother Teresa Solar energy Navbharat Times Terrorism Table

Recent work has established the efficacy of Amazon’s Mechanical Turk for constructing parallel corpora for machine translation research. We apply this to building a collection of parallel corpora between English and six languages from the Indian subcontinent: Bengali, Hindi, Malayalam, Tamil, Telugu, and Urdu. These languages are low-resource, under-studied, and exhibit linguistic phenomena that are difficult for machine translation. We conduct a variety of baseline experiments and analysis, and release the data to the community.
Implications of a health lifestyle and medication analysis for improving hypertension control.

BACKGROUND National Health and Nutritional Examination surveys have documented poor rates of hypertension treatment and control, leading to preventable morbidity and mortality. OBJECTIVES To examine covariation in the medication and health lifestyle beliefs and behaviors of persons with hypertension to identify and profile distinct subgroups of patients. METHODS A sample of 727 patients with hypertension, weighted to match the 1992 National Health Interview Survey age and sex distribution of patients with hypertension, was interviewed by telephone about their beliefs and behaviors regarding hypertension and its management. Cluster analysis of key variables was used to identify 4 patient types. RESULTS Subgroups differed significantly. Group A members use an effective mix of medication and health lifestyle regimens to control blood pressure. Group B members are most likely to depend on medication and have high adherence rates. Yet they also have high rates of smoking (29%) and alcohol use (average, 104 times per year) and are less likely to exercise regularly. Group C members are most likely to forget to take medication, are likely to be obese, and find it most difficult to comply with lifestyle changes (except for very low rates of smoking and alcohol use). Group D members are least likely to take medication, most likely to change or stop medication without consulting their physician (20%), most likely to smoke (40%), and least likely to control diet (29%). Group A and B members have better health outcomes than group C and D members. CONCLUSIONS Optimal management strategies are likely to differ for the 4 patient types. Further research should be conducted to validate these findings on a separate sample and to devise and test tailored management algorithms for hypertension compliance and control.
Towards co-evolution of fitness predictors and Deep Neural Networks

Deep neural networks proved to be a very useful and powerful tool with many practical applications. They especially excel at learning from large data sets with labeled samples. However, in order to achieve good learning results, the network architecture has to be carefully designed. Creating an optimal topology requires a lot of experience and knowledge. Unfortunately there are no practically applicable algorithms which could help in this situation. Using an evolutionary process to develop new network topologies might solve this problem. The limiting factor in this case is the speed of evaluation of a single specimen (a single network architecture), which includes learning based on the whole large dataset. In this paper we propose to overcome this problem by using a fitness prediction technique: use subsets of the original training set to conduct the training process and use its results as an approximation of specimen's fitness. We discuss the feasibility of this approach in context of the desired fitness predictor features and analyze whether subsets obtained in an evolutionary process can be used to estimate the fitness of the network topology. Finally we draw conclusions from our experiments and outline plans for future work.
Dream reflecting cultural contexts: comparing Brazilian and German diary dreams and most recent dreams

The continuity hypothesis states that waking life experiences, e.g., personal concerns and cultural environment, are reflected in dreams. The present study’s goal was to compare written dream reports from Brazilian and German samples. Overall, 97 Brazilian participants were included; two German samples from previous studies (N=89 and N=4197) were selected for comparison. The Brazilian participants reported 328 and the German participants 348 diary dreams. In addition, 86 Brazilian to 2893 German most recent dreams were compared. For both types of collected dreams, we found more bizarreness in German reports, and more depression-related topics in Brazilian reports. Germans reported more aggression in diary dreams and both more problems and more extreme emotions in most recent dreams. Brazilians reported more work- and leisure-related topics in diary dreams. Several similarities in dream content, e.g., no differences in verbal and physical interaction, number of male and female characters, and death-related themes, hint at universal characteristics of dreaming across cultures. We consider the clear group differences in dream content to reflect basic patterns of Brazilian and German cultures, which is exemplified through some core topics of the respective cultural sets. Concerning Brazil, the themes of miscegenation, emotional culture, and “saudade” (“longing”) are discussed. For German culture, the area of conflict between long-standing high-performance in science and arts and the contrasting twentieth century history is addressed. Future research should study the relation between dream content and culture in representative samples; to this purpose dream diaries, sampling daily average dreams, seem preferable to most recent dreams.
In situ shortening of CAG repeat length within the androgen receptor gene in prostatic cancer and its possible precursors

The amino‐terminal transcriptional activation domain of the androgen receptor (AR) gene contains two polymorphic trinucleotide repeat segments that encode polyglutamine (CAG)n and polyglycine (GGC)n tracts. Shorter CAG repeat lengths are associated with higher transcriptional activity. The previous studies using peripheral blood leukocytes showed the relationship between shorter CAG repeat length and risk for prostate cancer (PCA).
Biological variation of high sensitivity cardiac troponin-T in stable dialysis patients: implications for clinical practice

Background: Changes in high sensitivity cardiac troponin-T ( hs-cTnT) concentrations may reflect either acute myocardial injury or biological variation. Distinguishing between these entities is essential to accurate diagnosis, however, the biological variation of hs-cTnT in dialysis population is currently unknown. We sought to estimate the within- and between-person coefficients of variation of hs-cTnT in stable dialysis patients, and derive the critical difference between measurements needed to exclude biological variation with 99% confidence.
Allergic contact dermatitis from propyl gallate in desonide cream (Locapred®)

Case Report A 59-year-old man presented with an acute lesion of his penis, with swelling, erythema and edema, after using Locapred® cream (desonide) for 2 days. He had previously used the same cream without adverse effects and had no personal history of atopy or contact dermatitis. Patch tests produced positive reactions to neomycin and nickel in the European standard series, and to Locapred® cream and PG. Corticosteroids, preservatives and emulsifiers series were negative (Table I).
Sensorless control of surface permanent magnet synchronous motor using a structured adaptive flux observer

A new method of speed sensorless control and estimation for initial rotor position in the surface permanent magnet synchronous motor (SPMSM) drive is presented. At a rotating condition, speed and rotor position estimation of SPMSM drive is obtained through a self-adaptive flux observer (SAO) by only measuring three-phase voltages and currents. The initial rotor position is acquired by using the nonlinear magnetization characteristics of the stator core caused by the rotor magnets. Experimental results show that in both steady and transient states, the system can achieve expected performances.
A formal software verification concept based on automated theorem proving and reverse engineering

Formal software verification typically involves some levels of static theorem proving which is a mathematical process of proving that the function computed by a program match the function specified. A theorem prover, such as THEO, automates this process. On the other hand, reverse engineering is a process inverse to traditional engineering. An example extracts the software specification from its source code. In this paper we present a formal software verification concept, which is based on automated theorem proving and reverse engineering. We are mainly concerned with communications software and with software for families of communication protocols in particular. In the paper we describe how to: (1) model a group of finite state machines using predicate calculus; (2) extract axiomatic software specification from the source code and log files; and (3) formally verify software for a given operational profile (set of test cases). The concept has been successfully applied to a call processing software for systems, which are installed and fully operational in Moscow and Saint Petersburg, Russia.
Thermal storage capacity to enhance network flexibility in Dual Demand Side Management

The global concern for the environment and greater increase in the demand for electricity justifies integration of electrical and thermal units in the future smart grids to improve the system efficiency and reduce costs and emissions. In the distribution networks, micro-Combined Heat and Power unit equipped with a thermal storage system is an excellent candidate to meet the electrical and thermal demands. The aim of this paper is to present agent-based optimal control methodology to obtain higher flexibility for supplier to match the generations and demands. The market-based stochastic model for reducing the overall cost of generation and increasing the financial gain as long as supplying sufficient power to consumers in distribution level is described. The proposed algorithm is able to reach the optimum cost dispatching values according to different user behaviors and statistical data for switching micro-Combined Heat and Power units which are equipped with a thermal storage.
Drive Cycle Prediction and Energy Management Optimization for Hybrid Hydraulic Vehicles

Increasing costs of fossil fuels and the requirement of reduced CO2 emissions for road vehicles make the development of alternative propulsion systems a top priority in automotive research. Hybrid hydraulic vehicles (HHVs) can contribute to improving the fuel efficiency of heavy vehicles such as garbage trucks and city buses. The combination of a conventional diesel engine with an additional hydraulic powertrain allows for regenerative braking. Further improvements with regard to fuel efficiency become possible through additional optimization of the energy management strategy, which decides when to apply which propulsion system. Rule-based strategies are the state of the art, but they cannot utilize the full potential because their performance is only superior on the cycles for which they have been developed. Approaches including numerical optimization are independent from the actual drive cycle and result in much higher savings. However, these techniques usually require a prediction of the driving profile. In this paper, a complete solution for predictive energy management in HHVs is presented. The fuel savings obtained through the developed algorithms used for prediction and optimization are determined in a simulation study, and the functionality of the concept is proven in a hybrid hydraulic testing vehicle.
Survey of contemporary trends in color image segmentation

Abstract. In recent years, the acquisition of image and video information for processing, analysis, understanding, and exploitation of the underlying content in various applications, ranging from remote sensing to biomedical imaging, has grown at an unprecedented rate. Analysis by human observers is quite laborious, tiresome, and time consuming, if not infeasible, given the large and continuously rising volume of data. Hence the need for systems capable of automatically and effectively analyzing the aforementioned imagery for a variety of uses that span the spectrum from homeland security to elderly care. In order to achieve the above, tools such as image segmentation provide the appropriate foundation for expediting and improving the effectiveness of subsequent high-level tasks by providing a condensed and pertinent representation of image information. We provide a comprehensive survey of color image segmentation strategies adopted over the last decade, though notable contributions in the gray scale domain will also be discussed. Our taxonomy of segmentation techniques is sampled from a wide spectrum of spatially blind (or feature-based) approaches such as clustering and histogram thresholding as well as spatially guided (or spatial domain-based) methods such as region growing/splitting/merging, energy-driven parametric/geometric active contours, supervised/unsupervised graph cuts, and watersheds, to name a few. In addition, qualitative and quantitative results of prominent algorithms on several images from the Berkeley segmentation dataset are shown in order to furnish a fair indication of the current quality of the state of the art. Finally, we provide a brief discussion on our current perspective of the field as well as its associated future trends.
Biologia Plantarum Xx (x): Xxx-xxx, 20xx Nitric Oxide Donor Snp Regulates the Ascorbate and Glutathione Metabolism in Agropyron Cristatum Leaves through Mek1/2

This study investigated the role of the protein kinase MEK1/2 in the regulation of ascorbate and glutathione metabolism by nitric oxide in Agropyron cristatum leaves. The results showed that NO donor sodium nitroprusside (SNP) induced the increases activities of ascorbate peroxidase, glutathione reductase, monodehydroascorbate reductase, dehydroascorbate reductase, L-galactono-1,4-lactone dehydrogenase, and γ-glutamylcysteine synthetase (γ-ECS), the transcription of respective genes, and the content of reduced ascorbate, reduced glutathione, total ascorbate, and total glutathione. All the above increases except the activity of γ-ECS were suppressed by pre-treatment with MEK1/2 inhibitors 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one and
Series Resistance Extraction in Poly-Si TFTs With Channel Length and Mobility Variations

A new method to extract the series resistance (Rs) of polycrystalline silicon (poly-Si) thin-film transistors (TFTs) is proposed. Different from conventional methods, this method is based on an analytical poly-Si TFT model and is insensitive to channel length and mobility variations. This method is demonstrated in both n- and p-type poly-Si TFTs.
A broadside substrate integrated horn antenna

In this paper we have discussed a substrate integrated horn antenna that uses a slot in a ground plane as an aperture to radiate broadside. The SIRC to SIW transition has been analyzed separately and then has been used to feed the horn. A peak gain of almost 13 dBi has been achieved. The broadside substrate integrated horn antenna has many potential applications because of its low profile and compact design. Future research may include the study of the use of this horn as a feed for several other potential gain enhancing designs, such as stacked dielectric layers, dielectric resonator antennas, EBG structures, or reflectors.
anti-parasitic lead compounds Yeast-based automated high-throughput screens to identify

any medium, provided the original work is properly cited. Attribution License, which permits unrestricted use, distribution, and reproduction in This is an open-access article distributed under the terms of the Creative Commons Subject collections (2 articles) synthetic biology  (31 articles) microbiology  (4 articles) biotechnology  Articles on similar topics can be found in the following collections