Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring Issues Related to PTSD Versus Personality Disorder Diagnoses With Military Personnel

Since the wars in Iraq and Afghanistan began, the U.S. military has sent millions of troops into battlefield operations—some without proper training, some without rigorous preservice mental health checks, and many without experience. Many were given waivers that allowed them to skirt previously rigorous recruiting standards to bolster troop numbers. A significant amount of returning soldiers have been diagnosed with posttraumatic stress disorder (PTSD), and associated benefits and lifelong payouts for these soldiers have and will continue to cost the military hundreds of millions of dollars each year. The military has been accused of purposely changing PTSD diagnoses or instead issuing diagnoses of personality disorders—which the military considers a preexisting condition—for dodging these costs and as a mechanism for forcing soldiers out of service. This article explores how and why these diagnoses, or changes to existing diagnoses, are (allegedly) made, what purpose they serve the military, and the implications of each diagnosis for veterans and active duty soldiers. After reviewing this information, the question of whether or not the military should be ethically responsible for the continued mental health care of those soldiers after service, despite their condition, is addressed.
Exploiting vector instructions with generalized stream fusion

Stream fusion is a powerful technique for automatically transforming high-level sequence-processing functions into efficient implementations. It has been used to great effect in Haskell libraries for manipulating byte arrays, Unicode text, and unboxed vectors. However, some operations, like vector append, still do not perform well within the standard stream fusion framework. Others, like SIMD computation using the SSE and AVX instructions available on modern x86 chips, do not seem to fit in the framework at all. In this paper we introduce generalized stream fusion, which solves these issues. The key insight is to bundle together multiple stream representations, each tuned for a particular class of stream consumer. We also describe a stream representation suited for efficient computation with SSE instructions. Our ideas are implemented in modified versions of the GHC compiler and vector library. Benchmarks show that high-level Haskell code written using our compiler and libraries can produce code that is faster than both compiler- and hand-vectorized C.
Development of a monoclonal antibody against deoxynivalenol for magnetic nanoparticle-based extraction and an enzyme-linked immunosorbent assay

Monoclonal antibody (mAb, NVRQS-DON) against deoxynivalenol (DON) was prepared. DON-Ag coated enzyme linked immunosorbent assay (ELISA) and DON-Ab coated ELISA were prepared by coating the DON-BSA and DON mAb. Quantitative DON calculation ranged from 50 to 4,000 ng/mL for DON-Ab coated ELISA and from 25 to 500 ng/mL for DON-Ag coated ELISA. 50% of inhibitory concentration values of DON, HT-2, 15-acetyl-DON, and nivalenol were 23.44, 22,545, 5,518 and 5,976 ng/mL based on the DON-Ab coated ELISA. Cross-reactivity levels of the mAb to HT-2, 15-acetyl-DON, and nivalenol were 0.1, 0.42, and 0.40%. The intra- and interassay precision coefficient variation (CV) were both <10%. In the mAb-coated ELISA, mean DON recovery rates in animal feed (0 to 1,000 µg/kg) ranged from 68.34 to 95.49% (CV; 4.10 to 13.38%). DON in a buffer solution (250, 500 and 1,000 ng/mL) was isolated using 300 µg of NVRQS-DON and 3 mg of magnetic nanoparticles (MNPs). The mean recovery rates of DON using this mAb-MNP system were 75.2, 96.9, and 88.1% in a buffer solution spiked with DON (250, 500, and 1,000 ng/mL). Conclusively we developed competitive ELISAs for detecting DON in animal feed and created a new tool for DON extraction using mAb-coupled MNPs.
Significant expansion of the REST/NRSF cistrome in human versus mouse embryonic stem cells: potential implications for neural development

Recent studies have employed cross-species comparisons of transcription factor binding, reporting significant regulatory network ‘rewiring’ between species. Here, we address how a transcriptional repressor targets and regulates neural genes differentially between human and mouse embryonic stem cells (ESCs). We find that the transcription factor, Repressor Element 1 Silencing Transcription factor (REST; also called neuron restrictive silencer factor) binds to a core group of ∼1200 syntenic genomic regions in both species, with these conserved sites highly enriched with co-factors, selective histone modifications and DNA hypomethylation. Genes with conserved REST binding are enriched with neural functions and more likely to be upregulated upon REST depletion. Interestingly, we identified twice as many REST peaks in human ESCs compared to mouse ESCs. Human REST cistrome expansion involves additional peaks in genes targeted by REST in both species and human-specific gene targets. Genes with expanded REST occupancy in humans are enriched for learning or memory functions. Analysis of neurological disorder associated genes reveals that Amyotrophic Lateral Sclerosis and oxidative stress genes are particularly enriched with human-specific REST binding. Overall, our results demonstrate that there is substantial rewiring of human and mouse REST cistromes, and that REST may have human-specific roles in brain development and functions.
Rapid Identification and Characterization of Francisella by Molecular Biology and Other Techniques

Francisella tularensis is the causative pathogen of tularemia and a Tier 1 bioterror agent on the CDC list. Considering the fact that some subpopulation of the F. tularensis strains is more virulent, more significantly associated with mortality, and therefore poses more threat to humans, rapid identification and characterization of this subpopulation strains is of invaluable importance. This review summarizes the up-to-date developments of assays for mainly detecting and characterizing F. tularensis and a touch of caveats of some of the assays.
Risk Communication, Knowledge, and Attitudes: Explaining Reactions to a Technology Perceived as Risky

Several factors influence peoplesâ€™decisions about food irradiation, a technology perceived as risky. Responses to questions about three dimensions of acceptability of food irradiation provide the dependent variables. Risk message characteristics, respondent background characteristics, knowledge, and attitudes form the independent variables. Multiple regression is used to assess relative effects. Levels of acceptability of food irradiation varied somewhat as the focus of the question changed: negative reactions were more likely if the question mentioned serving it to family members than it it stressed self use. The only message manipulation that had a significant impact was information about irradiated food users (e.g., astronauts) and prestigious national and international organizations that endorse food irradiation. Support for a normative/value type of decisionâ€ making is more substantial than for a rational/technical type of decisionâ€ making. Although knowledge of food irradiation correlates with support for the technology, trust factors are much more powerful predictors. The implications for effective risk communications are discussed.
Joint Wireless Information and Energy Transfer in a Two-User MIMO Interference Channel

This paper investigates joint wireless information and energy transfer in a two-user MIMO interference channel, in which each receiver either decodes the incoming information data (information decoding, ID) or harvests the RF energy (energy harvesting, EH) to operate with a potentially perpetual energy supply. In the two-user interference channel, we have four different scenarios according to the receiver mode - (I<sub>D1</sub>, I<sub>D2</sub>), (E<sub>H1</sub>, E<sub>H2</sub>), (E<sub>H1</sub>, I<sub>D2</sub>), and (I<sub>D1</sub>, E<sub>H2</sub>). While the maximum information bit rate is unknown and finding the optimal transmission strategy is still open for (I<sub>D1</sub>, I<sub>D2</sub>), we have derived the optimal transmission strategy achieving the maximum harvested energy for (E<sub>H1</sub>, E<sub>H2</sub>). For (E<sub>H1</sub>, I<sub>D2</sub>), and (I<sub>D1</sub>, E<sub>H2</sub>), we find a necessary condition of the optimal transmission strategy and, accordingly, identify the achievable rate-energy (R-E) tradeoff region for two transmission strategies that satisfy the necessary condition - maximum energy beamforming (MEB) and minimum leakage beamforming (MLB). Furthermore, a new transmission strategy satisfying the necessary condition - signal-to-leakage-and-energy ratio (SLER) maximization beamforming - is proposed and shown to exhibit a better R-E region than the MEB and the MLB strategies. Finally, we propose a mode scheduling method to switch between (E<sub>H1</sub>, I<sub>D2</sub>) and (I<sub>D1</sub>, E<sub>H2</sub>) based on the SLER.
Vascular Targeted Nanoparticles for Imaging and Treatment of Brain Tumors

Purpose: Development of new therapeutic drug delivery systems is an area of significant research interest. The ability to directly target a therapeutic agent to a tumor site would minimize systemic drug exposure, thus providing the potential for increasing the therapeutic index. Experimental Design: Photodynamic therapy (PDT) involves the uptake of a sensitizer by the cancer cells followed by photoirradiation to activate the sensitizer. PDT using Photofrin has certain disadvantages that include prolonged cutaneous photosensitization. Delivery of nanoparticles encapsulated with photodynamic agent specifically to a tumor site could potentially overcome the drawbacks of systemic therapy. In this study, we have developed a multifunctional polymeric nanoparticle consisting of a surface-localized tumor vasculature targeting F3 peptide and encapsulated PDT and imaging agents. Results: The nanoparticles specifically bound to the surface of MDA-435 cells in vitro and were internalized conferring photosensitivity to the cells. Significant magnetic resonance imaging contrast enhancement was achieved in i.c. rat 9L gliomas following i.v. nanoparticle administration. Serial magnetic resonance imaging was used for determination of pharmacokinetics and distribution of nanoparticles within the tumor. Treatment of glioma-bearing rats with targeted nanoparticles followed by PDT showed a significant improvement in survival rate when compared with animals who received PDT after administration of nontargeted nanoparticles or systemic Photofrin. Conclusions: This study reveals the versatility and efficacy of the multifunctional nanoparticle for the targeted detection and treatment of cancer.
ENVIRONMENTAL HEALTH PHYSICS: 50 YEARS OF PROGRESS

Environmental health physics is an interdisciplinary field, involving study of the release, transport, and fate of radioactive material in the environment. Further, it addresses the interaction of humans with radioactive materials within the ambient (outdoor) environment and with the environments associated with modern technology and lifestyles. It also involves both naturally occurring and artificially produced radionuclides with the former generally being by far the highest source of exposure. In fact, doses from naturally occurring radionuclides are increasingly being used as a benchmark for the establishment of dose rate limits for people. Because of the pioneering work of early environmental health physicists, models exist today that can be used to assess the potential impacts of new nuclear facilities prior to their operation. In fact, these people represent the branch of the health physics profession who conducted environmental monitoring programs and performed the associated research studies that led to the identification of the principal radionuclides of interest, the major pathways and mechanisms through which they expose people, and the doses that may result from radioactive materials in the natural and technologically enhanced environments. One of their most important contributions was the identification and quantification of many of the key parameters that serve as input to such models. Monitoring of nuclear weapons development facilities used during and after World War II was the initial stimulus for the establishment of environmental health physics programs. Thereafter, these programs were expanded both nationally and globally, as a result of the atmospheric weapons testing programs of nations such as France, the People’s Republic of China, the former Soviet Union, the United Kingdom, and the United States. Additional stimuli were provided by the development of the commercial nuclear power industry. Current environmental programs, particularly within the U.S., focus on decontamination and decommissioning of dormant facilities from these earlier defense and commercial programs. The range of the environmental health physics aspects of these activities is the subject of this paper. Presented at the end of the paper is a summary of some of the more important lessons that have been learned. As will be noted, this is an exciting field that will present challenges to health physicists for years to come.
Robust and Efficient Multiple Alignment of Unsynchronized Meeting Recordings

This paper proposes a way to generate a single high-quality audio recording of a meeting using no equipment other than participants' personal devices. Each participant in the meeting uses their mobile device as a local recording node, and they begin recording whenever they arrive in an unsynchronized fashion. The main problem in generating a single summary recording is to temporally align the various audio recordings in a robust and efficient manner. We propose a way to do this using an adaptive audio fingerprint based on spectrotemporal eigenfilters, where the fingerprint design is learned on-the-fly in a totally unsupervised way to perform well on the data at hand. The adaptive fingerprints require only a few seconds of data to learn a robust design, and they require no tuning. Our method uses an iterative, greedy two-stage alignment algorithm which finds a rough alignment using indexing techniques, and then performs a more fine-grained alignment based on Hamming distance. Our proposed system achieves >99% alignment accuracy on challenging alignment scenarios extracted from the ICSI meeting corpus, and it outperforms five other well-known and state-of-the-art fingerprint designs. We conduct extensive analyses of the factors that affect the robustness of the adaptive fingerprints, and we provide a simple heuristic that can be used to adjust the fingerprint's robustness according to the amount of computation we are willing to perform.
Bone morphogenetic protein 4 signaling regulates development of the anterior visceral endoderm in the mouse embryo

The extraembryonic ectoderm (ExE) of the mouse conceptus is known to play a role in embryo patterning by signaling to the underlying epiblast and surrounding visceral endoderm. Bmp4 is one of the key ExE signaling molecules and has been recently implicated to participate in regulating development and migration of the anterior visceral endoderm (AVE). However, it remains unclear when exactly BMP4 signaling starts to regulate AVE positioning. To examine this, we have chosen to affect BMP4 function at two different time points, at embryonic day 5.25 (E5.25), thus before AVE migration, and E5.75, just after AVE migration. To this end, an RNAi technique was used, which consisted of the injection of Bmp4 dsRNA into the proamniotic cavity of the egg cylinder followed by its targeted electroporation into the ExE. This resulted in specific knockdown of Bmp4. It was found that Bmp4 RNAi at E5.25, but not at E5.75, led to an abnormal pattern of expression of the AVE marker Cerberus‐like. Thus, BMP4 signaling appears to affect the expression of Cer1 at a specific time window. This RNAi approach provides a convenient means to study spatial and temporal function of genes shortly after embryo implantation.
Adaptive coevolutionary networks: a review

Adaptive networks appear in many biological applications. They combine topological evolution of the network with dynamics in the network nodes. Recently, the dynamics of adaptive networks has been investigated in a number of parallel studies from different fields, ranging from genomics to game theory. Here we review these recent developments and show that they can be viewed from a unique angle. We demonstrate that all these studies are characterized by common themes, most prominently: complex dynamics and robust topological self-organization based on simple local rules.
Legitimating technologies: Ambiguity as a premise for negotiation in a networked institution

Discusses some issues related to the networking of an institution and presents the results of a field study. Institutions are bound not only to profit‐making but also to values and norms which shape their everyday lives; the introduction of computer technologies into institutional environments requires legitimization, not only in terms of time and money spared but also in terms of the perceived appropriateness of the new technological tools with respect to institutional goals. However, computer networks are not fixed objects, impermeable to the characteristics of the organizations in which they are introduced and used. On the contrary, they are configured by their users, to be adapted to their social environments. The field study, observed how members of an institution struggled to make sense of the introduction of a new computer network, and found that the final move in the process of legitimization was made by the institution itself, through a “committee for information technology”, which produced a normative artifact defining the official policy of the institution negotiating the new computer infrastructure.
Commentary on "Measurement of Central Aspects of Scientific Research"

This article presents a summary of recent work by the Leiden bibliometrics group, which van Raan has led so ably for more than 15 years. The group has established an excellent reputation for the thorough way in which it sets about the quantitative analysis of publications and for the new methods of working that it has pioneered. It is notable, too, for the series of Science and Technology Indicators conferences that it has run throughout Europe, beginning in Leiden in 1988. (Its eighth conference, again in Leiden, took place in September 2004.) A particular strength of the group is that its work is focused very much on practical matters—solving real problems of research evaluation for sponsors and research performers. Its work has meant that quantitative indicators are now well accepted in many quarters as an important adjunct to peer review. Indeed, they may provide an objective measure of research capability that is closer to the truth than the sometimes biased or partial views of review committees or individual referees. Nevertheless, this article has some serious shortcomings. There are four that I should like to address, of which the first two are the most important:
A brief and improper geography of queerspaces and sexpublics in Austin, Texas

This article offers ethnographic and autoethnographic vignettes from my research on cultures of public sex in Austin, Texas. It also tracks some of the ways my own racialization as a black queer man shaped the research project. My approach, which includes an experimental – ‘reparative’ – textual style, offers several interlocking registers of analysis. I bring together my informants' nostalgic remembrances of public sex in Austin; the legal and media circulation of queer sex in general, and public sex in particular, as specifically ‘public’ problems requiring surveillance, administration, and management; the impacts of HIV/AIDS; and the rise of the Internet as a means to connect. In this way, I not only aim to archive sites of desire and their transformation, but to also archive the everyday and intimate affects that animate, make sense of, and give meaning to queerspaces and sexpublics in Austin as elsewhere. In its eclectic mixes of voices and styles, as well as reality and fiction, my ethnography does not simply describe material geographies (men have sex in parks and hook up online) or linear timelines (first there was public sex and then there was AIDS), rather, gesturing as it does toward a psychic geography of intensities, remembrances, and longings, it tries to conjure an expansive affective archive into brief life.
Foundations of Cyclopean Perception

This classic work on cyclopean perception has influenced a generation of vision researchers, cognitive scientists, and neuroscientists and has inspired artists, designers, and computer graphics pioneers. In Foundations of Cyclopean Perception (first published in 1971 and unavailable for years), Bela Julesz traced the visual information flow in the brain, analyzing how the brain combines separate images received from the two eyes to produce depth perception. Julesz developed novel tools to do this: random-dot stereograms and cinematograms, generated by early digital computers at Bell Labs. These images, when viewed with the special glasses that came with the book, revealed complex, three-dimensional surfaces; this mode of visual stimulus became a paradigm for research in vision and perception. This reprint edition includes all 48 color random-dot designs from the original, as well as the special 3-D glasses required to view them.Foundations of Cyclopean Perception has had a profound impact on the vision studies community. It was chosen as one of the one hundred most influential works in cognitive science in a poll conducted by the University of Minnesota's Center for Cognitive Sciences. Many copies are "permanently borrowed" from college libraries; used copies are sought after online. Now, with this facsimile of the 1971 edition, the book is available again to cognitive scientists, neuroscientists, vision researchers, artists, and designers.
Stereotype Internalization, Math Perceptions, and Occupational Choices of Women With Counter-Stereotypical University Majors

Based on Eccles’ (1987) model of academic achievement-related decisions, we tested whether women, who are engaged in mathematical fields at university, have internalized, to some extent, the stereotype about women’s inferiority in math. The results indicate that men and women do not assess their ability self-concept, subjective value of math, or performance expectancies differently. However, women’s degree of stereotype endorsement has a negative impact on their ability self-concept and their performance expectancies, but does not affect their value of the math domain. Moreover, members of both genders envisage stereotypical careers after university graduation.
Named Entity Recognition in Albanian Based on CRFs Approach

Named Entity Recognition (NER) refers to the process of extracting named entities (people, locations, organizations, sport teams, etc.) from text documents. In this work we describe our NER approach for documents written in Albanian. We explore the use of Conditional Random Fields (CRFs) for this purpose. Adequate annotated training corpora are not yet publicly available for Albanian. We have created our own corpus annotated manually by humans. The domain of this corpus is based on Albanian news documents published in 2015 and 2016. We have tested our trained model with two test sets. Overall precision, recall and F-score are 83.2%, 60.1% and 69.7% respectively.