Miracle-dz/UniFAR-FTUs huggingface dataset:
Conservative Management of Osteoradionecrosis By Debridement, Sequestrectomy and Placement of An Obturator – A Clinical Report

Osteoradionecrosis is defined as an exposed irradiated bone that fails to heal over a period of three months without a residual or recurrent tumor. The risk factors for the development of ORN includes dose or radiation(> 50-60Gy), radiation area, patients with poor oral hygiene, recent dental extraction, malnutrition, immuno compromised status. The management of osteoradionecrosis varies from more conservative approach to the aggressive treatment modalities. In this clinical report we present a case of stage I osteoradionecrosis who underwent conservative management with obturator which shows excellent results.
Positive and Negative Regulation of Poly(A) Nuclease

ABSTRACT PAN, a yeast poly(A) nuclease, plays an important nuclear role in the posttranscriptional maturation of mRNA poly(A) tails. The activity of this enzyme is dependent on its Pan2p and Pan3p subunits, as well as the presence of poly(A)-binding protein (Pab1p). We have identified and characterized the associated network of factors controlling the maturation of mRNA poly(A) tails in yeast and defined its relevant protein-protein interactions. Pan3p, a positive regulator of PAN activity, interacts with Pab1p, thus providing substrate specificity for this nuclease. Pab1p also regulates poly(A) tail trimming by interacting with Pbp1p, a factor that appears to negatively regulate PAN. Pan3p and Pbp1p both interact with themselves and with the C terminus of Pab1p. However, the domains required for Pan3p and Pbp1p binding on Pab1p are distinct. Single amino acid changes that disrupt Pan3p interaction with Pab1p have been identified and define a binding pocket in helices 2 and 3 of Pab1p's carboxy terminus. The importance of these amino acids for Pab1p-Pan3p interaction, and poly(A) tail regulation, is underscored by experiments demonstrating that strains harboring substitutions in these residues accumulate mRNAs with long poly(A) tails in vivo.
Big Data Cloud Deduplication Based on Verifiable Hash Convergent Group Signcryption

As Big Data cloud storage servers are becoming popular the shortage of disk space in the cloud becomes a problem. Data deduplication is a method to control the explosion growth of data on the cloud and most of the storage providers are finding more secure and efficient methods for their sensitive data. Recently, an interesting technique called signcryption has been proposed, in which both the properties of signature (ownership) and encryption are simultaneously implemented, with better performance than the traditional signature-then-encryption approach. According to the deduplication, we introduce a new method for a group of users that can eliminate redundant encrypted data owned by different users. Furthermore, we generate the tag which will be the key component of big data management. We propose a new primitive group signcryption for deduplication called verifiable hash convergent group signcryption (VHCGS) by adding the properties of group signcryption and the verification facilities for the storage server (third party).
Contactless sensor technology for measuring soil moisture

The autonomous self-watering flowerpot facilitates the daily routine of plant owners and works as an extended green thumb. Plants are often neglected at home, because their owners are not capable to offer them the necessary attention due to physical or mental problems or a lack of time. In consequence, the plants die and reduce the desire for a green, healthy environment. This paper examines the use of a capacitive sensor for measuring soil moisture as the basis for an optimal irrigation of plants with the aim to create a user friendly product.
TopBP 1 functions with 53 BP 1 in the G 1 DNA damage checkpoint

TopBP1 is a checkpoint protein that colocalizes with ATR at sites of DNA replication stress. In this study, we show that TopBP1 also colocalizes with 53BP1 at sites of DNA double-strand breaks (DSBs), but only in the G1-phase of the cell cycle. Recruitment of TopBP1 to sites of DNA replication stress was dependent on BRCT domains 1–2 and 7–8, whereas recruitment to sites of DNA DSBs was dependent on BRCT domains 1–2 and 4–5. The BRCT domains 4–5 interacted with 53BP1 and recruitment of TopBP1 to sites of DNA DSBs in G1 was dependent on 53BP1. As TopBP1 contains a domain important for ATR activation, we examined whether it contributes to the G1 cell cycle checkpoint. By monitoring the entry of irradiated G1 cells into S-phase, we observed a checkpoint defect after siRNA-mediated depletion of TopBP1, 53BP1 or ATM. Thus, TopBP1 may mediate the checkpoint function of 53BP1 in G1. The EMBO Journal (2010) 29, 3723–3732. doi:10.1038/ emboj.2010. 238; Published online 24 September 2010 Subject Categories: cell cycle; genome stability & dynamics
Modeling the Energy-Time Performance of MIC Architecture System

Many Integrated Core (MIC) architecture systems are becoming increasingly popular for HPC applications as they have the dual-advantage of accelerating vector processing and a general-purpose programming model. One of the key challenges for energy-efficient execution on MIC architecture systems is to determine time and energy-efficient configurations among a large system configuration space. Given a parallel program with an execution time deadline and an energy budget, we propose a measurement-based analytical modeling approach to determine these system configurations. In contrast to current approaches, we model both inter-and intra-core resource overlaps, memory contention among threads within a core and memory contention across multiple cores. The model is validated against direct measurement using six representative HPC applications on Intel Xeon Phi system. We show that a Pareto frontier consisting of optimal configurations exist for a parallel program executing on MIC architecture systems. To further understand the Pareto frontier, we use the performance-to-power ratio metric (PPR), that quantifies the amount of useful computations performed per unit energy during the execution. The proposed approach can be used to determine what thread affinity is suitable for offloading execution to accelerators such as Xeon Phi and save energy.
Association of Aortic Stiffness With Left Ventricular Remodeling and Reduced Left Ventricular Function Measured by Magnetic Resonance Imaging: The Multi-Ethnic Study of Atherosclerosis

Background—This study sought to assess cross-sectional associations of aortic stiffness assessed by magnetic resonance imaging with left ventricular (LV) remodeling and myocardial deformation in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods and Results—Aortic arch pulse wave velocity (PWV) was measured with phase contrast cine magnetic resonance imaging. LV circumferential strain (Ecc), torsion, and early diastolic strain rate were determined by tagged magnetic resonance imaging. Multivariable linear regression models were used to adjust for demographics and cardiovascular risk factors. Of 2093 participants, multivariable linear regression models demonstrated that higher arch PWV was associated with higher LV mass index (B=0.53 per 1 SD increase for log-transformed PWV, P<0.05) and LV mass to volume ratio (B=0.015, P<0.01), impaired LV ejection fraction (LVEF; B=−0.84; P<0.001), Ecc (B=0.55; P<0.001), torsion (B=−0.11; P<0.001), and early diastolic strain rate (B=−0.003; P<0.05). In sex stratified analysis, higher arch PWV was associated with higher MVR (B=0.02; P<0.05), impaired Ecc (B=0.60; P<0.001), and LVEF (B=−0.45; P<0.05), but with maintained torsion in women. Higher PWV was associated with impaired Ecc (B=0.49; P<0.001) and LVEF (B=−1.21; P<0.001), with lower torsion (B=−0.17; P<0.001) in men. Conclusions—Higher arch PWV is associated with LV remodeling, and reduced LV systolic and diastolic function in a large multiethnic population. Greater aortic arch stiffness is associated with concentric LV remodeling and relatively preserved LVEF with maintained torsion in women, whereas greater aortic arch stiffness is associated with greater LV dysfunction demonstrated as impaired Ecc, torsion, and LVEF, with less concentric LV remodeling in men.
Learning Semantic and Visual Similarity for Endomicroscopy Video Retrieval

Content-based image retrieval (CBIR) is a valuable computer vision technique which is increasingly being applied in the medical community for diagnosis support. However, traditional CBIR systems only deliver visual outputs, i.e., images having a similar appearance to the query, which is not directly interpretable by the physicians. Our objective is to provide a system for endomicroscopy video retrieval which delivers both visual and semantic outputs that are consistent with each other. In a previous study, we developed an adapted bag-of-visual-words method for endomicroscopy retrieval, called “Dense-Sift,” that computes a visual signature for each video. In this paper, we present a novel approach to complement visual similarity learning with semantic knowledge extraction, in the field of in vivo endomicroscopy. We first leverage a semantic ground truth based on eight binary concepts, in order to transform these visual signatures into semantic signatures that reflect how much the presence of each semantic concept is expressed by the visual words describing the videos. Using cross-validation, we demonstrate that, in terms of semantic detection, our intuitive Fisher-based method transforming visual-word histograms into semantic estimations outperforms support vector machine (SVM) methods with statistical significance. In a second step, we propose to improve retrieval relevance by learning an adjusted similarity distance from a perceived similarity ground truth. As a result, our distance learning method allows to statistically improve the correlation with the perceived similarity. We also demonstrate that, in terms of perceived similarity, the recall performance of the semantic signatures is close to that of visual signatures and significantly better than those of several state-of-the-art CBIR methods. The semantic signatures are thus able to communicate high-level medical knowledge while being consistent with the low-level visual signatures and much shorter than them. In our resulting retrieval system, we decide to use visual signatures for perceived similarity learning and retrieval, and semantic signatures for the output of an additional information, expressed in the endoscopist own language, which provides a relevant semantic translation of the visual retrieval outputs.
Feasibility for Measuring Transverse Area Ratios and Asymmetry of Lumbosacral Region Paraspinal Muscles in Working Dogs Using Computed Tomography

Objectives Describe computed tomographic (CT) anatomy of canine lumbosacral (LS) paraspinal muscles, a method for measuring paraspinal muscle transverse area ratios and asymmetry using CT, and application of this method in a small sample of working dogs with versus without LS pain. Methods Published anatomy references and atlases were reviewed and discrepancies were resolved by examination of anatomic specimens and multiplanar reformatted images to describe transverse CT anatomy of LS region paraspinal muscles. Sixteen Belgian malinois military working dogs were retrospectively recruited and assigned to LS pain positive versus negative groups based on medical record entries. A single observer unaware of dog group measured CT transverse areas of paraspinal muscles and adjacent vertebral bodies, in triplicate, for L5–S1 vertebral locations. A statistician compared muscle transverse area ratios and asymmetry at each vertebral location between groups. Results The relative coefficient of variation for triplicate CT area measurements averaged 2.15% (N = 16). Multifidus lumborum (L6–7), psoas/iliopsoas (L5–6, L6–7), and sacrocaudalis dorsalis lateralis (L6–7, L7–S1) transverse area ratios were significantly smaller in dogs with LS pain (n = 11) versus without LS pain (n = 5) (p ≤ 0.05). Muscle asymmetry values were not significantly greater in dogs with versus without LS pain. Clinical relevance Computed tomographic morphometry of LS region paraspinal muscles is a feasible objective method for use in future evidence-based research studies in working dogs. Potential future research applications include determining whether decreased paraspinal muscle area ratios and/or increased paraspinal muscle asymmetry could be used as markers for preclinical LS pain in stoic dogs or risk factors for other injuries in high performance canine athletes, or determining whether core muscle strengthening exercise prescriptions for dogs with LS pain have an effect on paraspinal muscle area ratios and asymmetry.
catena-Poly[[dibromidozinc(II)]-μ-4-(3-pyridyl)-4H-1,2,4-triazole]

The title complex, [ZnBr2(C7H6N4)]n, was formed under hydrothermal conditions using the ligand 4-(3-pyridyl)-4H-1,2,4-triazole (L). The unique ZnII ion is coordinated by one triazole N atom, one pyridine N atom and two Br atoms in a slightly distorted tetrahedral coordination environment. Symmetry-related ZnII ions are connected by bridging L ligands into chains parallel to [001] in which the Zn⋯Zn separation is 8.643 (7) Å. In the crystal structure, weak intermolecular C—H⋯Br hydrogen bonds link the chains into a three-dimensional network.
Effects of dopamine and epinephrine infusions on renal hemodynamics in severe malaria and severe sepsis

Objective: To describe and compare the effects of dopamine and epinephrine in various doses on renal hemodynamics and oxygen transport in patients with severe malaria and severe sepsis. Design: Prospective, controlled, crossover trial. Setting: The intensive care unit of an infectious diseases hospital in Viet Nam. Patients: Fourteen patients with severe falciparum malaria and five with severe sepsis. Interventions: In an open, crossover design, we observed the effects on renal and systemic hemodynamics and oxygen transport of separate stepped infusions of epinephrine and dopamine. We measured renal blood flow (RBF) and cardiac output by the thermodilution method using fluoroscopically guided catheters. Creatinine clearance at each time point was calculated from the renal plasma flow and the renal arteriovenous difference in plasma creatinine. Measurements and Main Results: Dopamine at a "renal" dose (2.5 μg/kg/min) was associated with a mean (95% confidence interval) fractional increase in the absolute renal blood flow index (RBFI) of 37% (13% to 61%) and in RBF as a fraction of cardiac output (RBF/CO) of 35% (10% to 59%; p = .007 and p = .014, respectively). The consequent 39% (14% to 64%) increase in renal oxygen supply (p = .002) was accompanied by a 32% (20% to 44%) decrease in the renal oxygen extraction ratio (p = .0003), leading to no net change in renal oxygen consumption. At higher doses (10 μg/kg/min), both RBF and RBF/CO were not significantly different from baseline values and decreased further as the dose was reduced again. There was no obvious explanation for this hysteresis. There was no change in renal oxygen consumption throughout the study. Because lactic acidosis developed, epinephrine was only given to eight of the 19 patients, and the full stepped epinephrine infusion was given to four patients. Epinephrine infusion was associated, both in absolute terms and when compared with dopamine, with a significant increase in renal vascular resistance (p = .0008 and .0005, respectively), a decrease in RBF/CO (p = .002 and .03), and a compensatory increase in the renal oxygen extraction ratio (p = .005 and .0001). RBFI and renal oxygen consumption remained constant throughout the epinephrine infusion profile. Neither epinephrine nor dopamine significantly affected creatinine clearance or urine output. Twelve patients (63%) were in established renal failure (plasma creatinine, >3 mg/dL) at the time of the study, although the presence or absence of renal failure did not significantly influence the effects of the study drugs. However, overall, the presence of renal failure was associated with a lower mean renal oxygen consumption, a lower mean renal oxygen consumption as a fraction of systemic oxygen consumption, and a higher mean renal vascular resistance. Conclusion: Although dopamine increased and epinephrine decreased fractional renal blood flow, there was no evidence that either drug produced either a beneficial or a deleterious effect on renal oxygen metabolism or function at any of the doses investigated.
DESCRIPTIVE SENSORY ANALYSIS OF WINE VINEGAR: TASTING PROCEDURE AND RELIABILITY OF NEW ATTRIBUTES

ABSTRACT A procedure for the sensory analysis of vinegar, which provides reproducible results and minimizes the standard deviation of attributes, was developed. A new tasting protocol was proposed that leads to low dispersions of panelists' answers. The list of attributes that describe vinegars was extended to a total of 13, the importance (or discriminant utility) of which was analyzed by using Partial Least Squares Regression related techniques. The attributes selected showed a good between-run reproducibility as was shown by the Discriminant Partial Least Squares Regression analysis on replications. The proposed methodology proved to be useful for tasting very different types of wine vinegars (i.e., sherry and red and white wine vinegars). PRACTICAL APPLICATIONS As the vinegar market is now making products from different raw materials, we believed that it would be interesting to improve sensory analysis. The European Union (EU) regulates the sensory analysis of oil but not of vinegar. Our manuscript describes a tasting protocol that aims to provide more reproducible results, proposes a broader vocabulary for describing vinegars and uses statistical tools to verify the reliability of new attributes.
Social support in single parents' transition from welfare to work: Analysis of qualitative findings†

Cook KE. Social support in single parents' transition from welfare to work: Analysis of qualitative findings Since 1995, single parents have been required to participate in welfare-to-work activities. While quantitative meta-analyses have consolidated the social and economic impacts of such transitions, no attempt has yet been made to synthesise the qualitative evidence. In this article, I offer an analysis of 16 qualitative articles that explore the role of social support in the lives of single mothers making the transition from welfare to work. By focusing on the functions and reciprocal nature of social support, this study examined how welfare-to-work programmes shift women's dependence from the state onto family and friends, many of whom are in similarly impoverished situations and/or are unable to provide adequate support. Furthermore, women are often required to reciprocate the support they receive, which creates additional barriers to a successful welfare-to-work transition.
Effects of perch availability on performance, carcass characteristics, and footpad lesions in broilers

Abstract. In the modern broiler industry, solutions are still being sought to improve conditions or eliminate problems related to issues such as animal welfare, health, and meat quality brought by intensive production systems. Therefore, this experiment was conducted to study effects of perching on growth performance, carcass characteristics, and footpad lesions (FPLs) in broiler chickens. A total of 300 broiler chicks (Ross 308) were distributed into control and perch groups with three replicates including equal numbers of males and females. The perch group contained two single perches in each pen. Analysis of camera records revealed that on average 7.36 % of the birds using perches. Perch use did not have any effect on growth performance (P > 0.05), but had a positive effect on FPLs (P 0.05). Thigh and breast meat color was less yellow (P These findings suggest that perch use has positive effect on FPLs. The reduction of redness in the breast could indicate that perch use may have a positive effect on breast inflammation. The potential positive effects of adapting perch use to intensive conditions should be further investigated.
PD-Survey: Supporting Audience-Centric Research through Surveys on Pervasive Display Networks

We present PD-Survey, a platform to conduct surveys across a network of interactive screens. Our research is motivated by the fact that obtaining and analyzing data about users of public displays requires signi cant effort; e.g., running long-term observations or post-hoc analyses of video/interaction logs. As a result, research is often constrained to a single installation within a particular context, neither accounting for a diverse audience (children, shoppers, commuters) nor for different situations (waiting vs. passing by) or times of the day. As displays become networked, one way to address this challenge is through surveys on displays, where audience feedback is collected insitu. Since current tools do not appropriately address the requirements of a display network, we implemented a tool for use on public displays and report on its design and development. Our research is complemented by two in-the-wild deployments that (a) investigate di erent channels for feedback collection, (b) showcase how the work of researchers is supported, and (c) testify that the platform can easily be extended with novel features.
Numerical Magneto Hydro Dynamic Flow Simulation of Velocity and Pressure for Electrically Conducting, Incompressible Fluids

In this paper, we report on numerical simulations of incompressible MagnetoHydroDdynamic flows by a two dimensional finite difference scheme associated to an appropriate projection method performed to characterize velocity-pressure formulations along the specified MHD duct by solving the set of differential equations of magnetohydrodynamics. In the present calculation, a working electrolytic solution is considered in order to bring up the application of the magnetohydrodynamic micropump. Numerical results show the characteristics of flow velocity, pressure distribution and their convergence tests. The computations aim to optimize the flow rate of a given MHD micropump regarding to its geometrical dimensions and the external electromagnetic excitation.
Fatty Acids and Hypoxia Stimulate the Expression and Secretion of the Adipokine ANGPTL4 (Angiopoietin-Like Protein 4/ Fasting-Induced Adipose Factor) by Human Adipocytes

Background/Aims: Hypoxia occurs in white adipose tissue in obesity, modulating the expression and release of specific inflammation-related adipokines. ANGPTL4 (angiopoietin-like protein 4/fasting-induced adipose factor), which is implicated in angiogenesis, lipid metabolism and glucose homeostasis, is a major hypoxia-sensitive gene; recent studies indicate that ANGPTL4 expression is also regulated by fatty acids. We have examined the effects of hypoxia and fatty acids, alone and together, on the expression and release of ANGPTL4 by human adipocytes. Methods: Human adipocytes were differentiated and incubated with fatty acids (250 µM) in normoxia (21% O2) or hypoxia (1% O2). ANGPTL4 mRNA was measured by real-time PCR and the protein in the medium determined by ELISA. Results: In normoxia, ANGPTL4 gene expression was upregulated by palmitic, oleic, arachidonic and eicosapentaenoic acids, and ANGPTL4 release was increased. In contrast, there was no effect of lauric or myristic acids. Hypoxia alone increased the expression and secretion of ANGPTL4, and lauric, myristic, arachidonic and eicosapentaenoic acids each further increased expression and release in hypoxic adipocytes. Conclusion: The expression and secretion of ANGPTL4 by human adipocytes is upregulated by both hypoxia and fatty acids. The stimulatory effect of fatty acids on ANGPTL4 production is augmented under hypoxic conditions.