Miracle-dz/UniFAR-FTUs huggingface dataset:
The Future of Surface Artefact Survey in Europe. John L. Bintliff, Martin Kuna, and Natalie Venclová, editors. 2001. Sheffield Academic Press, Sheffield, England, xii + 120 pp. $60.00 (cloth), ISBN 1-84127-134-9.

This volume stems from a session at the second annual meeting of the European Association of Archaeologists in Riga, 1996. For the most part, the various authors successfully attain the stated goal of providing not only glimpses of the range of surface survey methodologies in Europe, but honest assessments of the limitations and potential problems with the data generated. In chapter 2, John Bintliff reflects upon the results of approximately 20 years of "continuous landscape recording" survey in Greece. From his recent work in Boeotia, the author focuses on the limitations and potential biases in data recovered by intensive surface survey and offers possible solutions. Chief among the problems identified by Bintliff are: biased representation of temporal components; determining contemporaneity of sites within particular periods; inability to account for buried, vestigial, or obscured sites; invisibility of particular components due to temporal variability in artifact density; and lack of social and economic frameworks to interpret data derived from surface surveys. While this chapter is well illustrated, one key map (Figure 2.7) is difficult to interpret: where exactly are the rural sites, and why is site CN15 located off the map itself?
Problem Internet Overuse Behaviors in College Students: Readiness-to-Change and Receptivity to Treatment

This mixed methods study explores college students' readiness-to-change and receptivity to treatment for problem Internet overuse behaviors. Focus groups were conducted with 27 college students who self-identified as Internet over-users, and had experienced biopsychosocial problems related to Internet overuse. Participants completed standardized questionnaires assessing their Internet use and sociodemographic forms. Focus groups explored readiness to change problem Internet overuse behaviors and receptivity to treatment. Similar to college students with other addictive behaviors, students with problem Internet overuse fall along a continuum vis-à-vis readiness-to-change their behaviors. Over half of the participants were receptive to treatment for their problem Internet overuse behaviors.
DiVA: exploring the usage of pupil diameter to elicit valence and arousal

Most of the typical digital systems are not fully aware of the users' affect states. Adapting to the users' state showed great potential for enhancing user experiences. However, most approaches for sensing affective states, specifically arousal and valence, involve expensive and obtrusive technologies, such as physiological sensors attached to users' bodies. This paper present an indicator of the users' affect based on eye tracking. We use a commercial eye tracker to monitor the user's pupil size to estimate their arousal and valence in response to videos of different content. To assess the effect of different content (namely pleasant and unpleasant) influencing the arousal and valence on the pupil diameter, we conducted a user study with 25 participants. The study showed that different content of videos affect the pupil diameter, thereby giving an indicator about the user's state. We provide empirical evidence showing how to unobtrusively detect changes in users' state. Our initial investigation gives rise to eye-based user's tracking, which introduces the potential of new applications in the field of affect-aware computing.
Imaging in rheumatoid arthritis: options, uses and optimization

Recent advances in imaging technology are dramatically changing the approach to patients with inflammatory arthritis. Conventional radiography is still the major imaging modality used to evaluate patients with rheumatoid arthritis in daily clinical practice. In the last decade, several investigations have shown the diagnostic ability of MRI and ultrasound to rectify the traditional approach to early diagnosis and disease activity monitoring. This review will summarize the options, uses and optimization of these imaging modalities with a special focus on ultrasound, which is currently the most promising tool to change the paradigms in both early diagnosis and therapy monitoring of rheumatoid arthritis.
An Online Intervention for Co-Occurring Depression and Problematic Alcohol Use in Young People: Primary Outcomes From a Randomized Controlled Trial

Background Depression and problematic alcohol use represent two of the major causes of disease burden in young adults. These conditions frequently co-occur and this is associated with increased harm and poorer outcomes than either disorder in isolation. Integrated treatments have been shown to be effective; however, there remains a significant gap between those in need of treatment and those receiving it. The increased availability of eHealth programs presents a unique opportunity to treat these conditions. Objective This study aimed to evaluate the feasibility and preliminary efficacy of an automated Web-based self-help intervention (DEAL Project) in treating co-occurring depressive symptoms and problematic alcohol use in young people. Methods Young people (aged 18 to 25 years) with moderate depression symptoms and drinking at hazardous levels (recruited largely via social media) were randomly allocated to the DEAL Project (n=60) or a Web-based attention-control condition (HealthWatch; n=44). The trial consisted of a 4-week intervention phase with follow-up assessment at posttreatment and at 3 and 6 months postbaseline. The primary outcomes were change in depression severity according to the Patient Health Questionnaire-9 as well as quantity and frequency of alcohol use (TOT-AL). Results The DEAL Project was associated with statistically significant improvement in depression symptom severity (d=0.71) and reductions in alcohol use quantity (d=0.99) and frequency (d=0.76) in the short term compared to the control group. At 6-month follow-up, the improvements in the intervention group were maintained; however, the differences between the intervention and control groups were no longer statistically significant, such that between-group effects were in the small to moderate range at 6 months (depression symptoms: d=0.39; alcohol quantity: d=–0.09; alcohol frequency: d=0.24). Conclusions Overall, the DEAL Project was associated with more rapid improvement in both depression symptoms and alcohol use outcomes in young people with these co-occurring conditions relative to an attention-control condition. However, long-term outcomes are less clear. Trial Registration Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12613000033741; https://www.anzctr. org.au/Trial/Registration/TrialReview.aspx? id=363461 (Archived by WebCite at http://www.webcitation.org/6fpsLEGOy)
Genome Diversity of Pseudomonas aeruginosa PAO1 Laboratory Strains

ABSTRACT Pseudomonas aeruginosa PAO1 is the most commonly used strain for research on this ubiquitous and metabolically versatile opportunistic pathogen. Strain PAO1, a derivative of the original Australian PAO isolate, has been distributed worldwide to laboratories and strain collections. Over decades discordant phenotypes of PAO1 sublines have emerged. Taking the existing PAO1-UW genome sequence (named after the University of Washington, which led the sequencing project) as a blueprint, the genome sequences of reference strains MPAO1 and PAO1-DSM (stored at the German Collection for Microorganisms and Cell Cultures [DSMZ]) were resolved by physical mapping and deep short read sequencing-by-synthesis. MPAO1 has been the source of near-saturation libraries of transposon insertion mutants, and PAO1-DSM is identical in its SpeI-DpnI restriction map with the original isolate. The major genomic differences of MPAO1 and PAO1-DSM in comparison to PAO1-UW are the lack of a large inversion, a duplication of a mobile 12-kb prophage region carrying a distinct integrase and protein phosphatases or kinases, deletions of 3 to 1,006 bp in size, and at least 39 single-nucleotide substitutions, 17 of which affect protein sequences. The PAO1 sublines differed in their ability to cope with nutrient limitation and their virulence in an acute murine airway infection model. Subline PAO1-DSM outnumbered the two other sublines in late stationary growth phase. In conclusion, P. aeruginosa PAO1 shows an ongoing microevolution of genotype and phenotype that jeopardizes the reproducibility of research. High-throughput genome resequencing will resolve more cases and could become a proper quality control for strain collections.
Ultra-wideband design of a magneto-optical isolator operating in 1.31μm and 1.5 μm

An ultra-wideband magneto-optical isolator operating in 1.31 μm and 1.55 μm is designed. This isolator provides isolation ratio of more than 30 dB and forward loss of less than 0.9 dB at the wavelength range from 1.25 μm to 1. 59μm.
Clinical implications of vancomycin-resistant Enterococcus faecium (VRE) with VanD phenotype and vanA genotype.

OBJECTIVES To investigate the clinical implications of vancomycin-resistant Enterococcus faecium (VRE) with VanD phenotype and vanA genotype (VanD-vanA VRE). METHODS We tested in vitro and in vivo efficacies of teicoplanin against VanD-vanA VRE strains. Change in teicoplanin MICs was monitored during incubation with teicoplanin. In vitro and in vivo time-kill assay and survival analysis using a mouse peritonitis model were performed. RESULTS Teicoplanin MICs of VanD-vanA VRE strains increased to 128 mg/L within 48 h when they were cultured with 120 mg/L teicoplanin. In vitro and in vivo time-kill assay showed that VanD-vanA VRE strains were not eliminated by 120 mg/L teicoplanin in contrast to vancomycin-susceptible E. faecium and VanD-vanB strains. The survival rate of mice infected with VanD-vanA VRE strains treated with teicoplanin was comparable with that of untreated mice. CONCLUSION Data suggest that teicoplanin would fail in the treatment of VanD type VRE infections if the strains contained the vanA gene, which cannot be detected in the clinical microbiology laboratory.
Design and optimisation of grid compliant variable-flux PM synchronous generator for wind turbine applications

In this paper a grid compliant variable-flux PM generator topology for wind turbine applications is proposed. An analytical comparative study of a series-double excited synchronous generator and an electrically excited synchronous generator (SG) is carried out with particular focus on the amount of MMF required to satisfy grid codes. A finite element based design optimization of the proposed generator is described in detail. The optimisation process has been explored on the basis of dq steady state currents, rated torque, no-load voltage, variable-flux and minimum rotor-copper-mass. The results show amongst other things that a relatively low amount of rotor field winding copper is necessary for a variable-flux PMSG to be grid compliant.
Splenectomy for patients with myelofibrosis with myeloid metaplasia: pretreatment variables and outcome prediction.

Since according to the early studies, the outcome after splenectomy in the individual patient with myelofibrosis with myeloid metaplasia (MMM) is unpredictable, we assessed retrospectively the pre-intervention characteristics that best predicted adverse events, hematological consequences, and survival in 71 splenectomized MMM patients. The findings indicate that the operative risk of splenectomy for both mortality (8.4%) and morbidity (39.3%) was unpredictable. New hemorrhagic or thrombotic complications occurred in 16.9% of surviving patients and were predicted by age < 50 years, a normal to high platelet count (> 200 x 10(9)/l) and huge splenomegaly (> 16 cm from the costal margin). Massive liver enlargement occurred in 24% of patients and has to be expected in patients splenectomized for transfusion-dependent anemia. Anemia improved substantially in 45% and 52% of patients at 3 months and at 1 year, respectively, and was predicted by severe anemia, low platelet count (< 100 x 10(9)/l) or normal to high white blood cell (WBC) count (> 4 x 10(9)/l). Survival from splenectomy was superior in patients < 45 years with WBC < 10 x 10(9)/l count. An unexpectedly high rate of blastic transformation was observed. It accounted for 42.8% of the deaths. The results suggest trials for prophylactic cytoreductive treatment in young patients and when platelet count is normal to increased. Further study is needed for elucidating the possible role played by splenectomy in inducing blastic transformation.
Application of mixed methods for exploration of the association of job stress and hypertension among software professionals in Bengaluru, India

Context: Quantitative and Qualitative studies have been widely used in isolation to estimate several associations in developing countries, but little is known about combining both methods in a given study and ascertains validity. Aims: The objective of the following study was to accurately measure the constructs and to check for the internal consistency whereas measuring occupational stress among software professionals. We compared contextual stressors developed from the qualitative study with occupational stress index (OSI) among Information Technology/Information Technology Enabled Service (IT/ITES) professionals in India. Settings and Design: We employed mixed methods sampling strategy for selecting the IT/ITES professionals for the study. The first stage involved a qualitative study followed by a cross-sectional study among 1071 workers in the IT and ITES sector in Bengaluru. Materials and Methods: There were two types of stress domains used in the questionnaire. First, contextual stress domains, which were constructed based on the results of the qualitative study. Second, we used OSI for computer workers. Statistical Analysis Used: Data from the cross sectional survey was analyzed using SAS 9.1. (SAS Institute Inc., Cary, NC, USA). We used Cronbach's coefficient alpha for analyzing latent constructs of OSI and contextual stress domains. Results: The results indicate that OSI doesn’t correlate well with contextual stressors. Conclusions: OSI is a generic questionnaire designed for a computer worker and using the contextual stressors based on the results from the qualitative study might capture the occupational stressors more reliably.
Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice

To develop specific conditional gene ablation in the hematopoietic myeloid‐osteoclast lineage, transgenic mice expressing Cre recombinase under the control of the CD11b promotor were generated on the C57BL/6 background. The cellular specificity of Cre activity following recombination was quantified in the Z/EG reporter transgenic mice by FACS analysis with lineage‐specific markers and EGFP coexpression. A high degree of recombination, as evidenced by EGFP‐positive cells, was demonstrated in macrophages and granulocytes of bone marrow and spleen by the presence of double‐positive cells CD11b/EGFP and Gr1/EGFP, respectively. Interestingly, the peritoneal macrophage population showed almost complete DNA recombination at large. Most important, mature osteoclast cells derived from the double transgenic bone marrow and spleen progenitors were EGFP‐positive. Hence, these CD11b‐Cre mice will provide a unique tool to unravel novel gene function and activities involved during osteoclast and macrophage differentiation and maturation processes. genesis 41:138–145, 2005. © 2005 Wiley‐Liss, Inc.
Calculation of parameters in model Hamiltonians.

The ab initio calculation of parameters of the Anderson model is illustrated within the framework of a simple, exactly solvable, model of a 3d compound. It is shown how the latter model can be mapped onto a simpler model, by projecting out degrees of freedom, and by including these degrees of freedom implicitly as a renormalization of parameters. For the model studied this approach is shown to be exact in the limit when the projected degrees of freedom correspond to very delocalized electrons.
Immune response to Japanese rabies vaccine in domestic dogs.

To evaluate the immune response induced by Japanese rabies vaccine for veterinary use as international units (IU), we measured levels of rabies antibody in serum samples from dogs by the rapid fluorescent focus inhibition test (RFFIT). In dogs immunized with a reference vaccine (potency level of 3.1 IU/ml), prepared by the same method as that used to produce commercial vaccine, and its dilutions (1 : 2 or 1 : 4), neutralizing-antibody levels increased to 1.0-2.0 IU/ml over a period of 1 month and then decreased to 0.2-1.5 IU/ml over a period of 1 year after the first vaccination and showed a remarkable increase to 12-47 IU/ml after the second vaccination. Sixty-five (74.7%) of the 87 serum samples from domestic dogs that were tested were seropositive (> or =0.1 IU/ml). However, the seropositive rate in dogs less than 1-year old at the time of vaccination was low (57.1%), and the antibody levels in these dogs were not sufficiently high for the rabies antibody titre in serum to be maintained for 1-year. Levels of rabies antibody in all serum samples were also measured by the virus neutralizing test (VNT), and a strong correlation (r > 0.95) was found between the results of the RFFIT and those of the VNT.
Solving pressure vessel design problems by an effective global harmony search algorithm

We use an effective global harmony search algorithm (EGHS) to solve two kinds of pressure vessel design problems. In general, the two problems are formulated as mixed-integer non-linear programming problems with several constraints. The EGHS combines harmony search algorithm (HS) with concepts from the swarm intelligence of particle swarm optimization algorithm (PSO) to solve the two optimization problems. The EGHS algorithm has been applied to two typical problems with results better than previously reported. The results have demonstrated that the EGHS has strong convergence and capacity of space exploration on solving pressure vessel design problems.
Paraphrasing and translation

Paraphrasing and translation have previously been treated as unconnected natural language processing tasks. Whereas translation represents the preservation of meaning when an idea is rendered in the words in a different language, paraphrasing represents the preservation of meaning when an idea is expressed using different words in the same language. We show that the two are intimately related. The major contributions of this thesis are as follows: • We define a novel technique for automatically generating paraphrases using bilingual parallel corpora, which are more commonly used as training data for statistical models of translation. • We show that paraphrases can be used to improve the quality of statistical machine translation by addressing the problem of coverage and introducing a degree of generalization into the models. • We explore the topic of automatic evaluation of translation quality, and show that the current standard evaluation methodology cannot be guaranteed to correlate with human judgments of translation quality. Whereas previous data-driven approaches to paraphrasing were dependent upon either data sources which were uncommon such as multiple translation of the same source text, or language specific resources such as parsers, our approach is able to harness more widely parallel corpora and can be applied to any language which has a parallel corpus. The technique was evaluated by replacing phrases with their paraphrases, and asking judges whether the meaning of the original phrase was retained and whether the resulting sentence remained grammatical. Paraphrases extracted from a parallel corpus with manual alignments are judged to be accurate (both meaningful and grammatical) 75% of the time, retaining the meaning of the original phrase 85% of the time. Using automatic alignments, meaning can be retained at a rate of 70%. Being a language independent and probabilistic approach allows our method to be easily integrated into statistical machine translation. A paraphrase model derived from parallel corpora other than the one used to train the translation model can be used to increase the coverage of statistical machine translation by adding translations of previously unseen words and phrases. If the translation of a word was not learned, but a translation of a synonymous word has been learned, then the word is paraphrased
Flux upper limits for 47 AGN observed with H.E.S.S. in 2004−2011

About 40% of the observation time of the High Energy Stereoscopic System (H.E.S.S.) is dedicated to studying active galactic nuclei (AGN), with the aim of increasing the sample of known extragalactic very-high-energy (VHE, E>100 GeV) sources and constraining the physical processes at play in potential emitters. H.E. S.S. observations of AGN, spanning a period from April 2004 to December 2011, are investigated to constrain their gamma-ray fluxes. Only the 47 sources without significant excess detected at the position of the targets are presented. Upper limits on VHE fluxes of the targets were computed and a search for variability was performed on the nightly time scale. For 41 objects, the flux upper limits we derived are the most constraining reported to date. These constraints at VHE are compared with the flux level expected from extrapolations of Fermi-LAT measurements in the two-year catalog of AGN. The H.E. S.S. upper limits are at least a factor of two lower than the extrapolated Fermi-LAT fluxes for 11 objects. Taking into account the attenuation by the extragalactic background light reduces the tension for all but two of them, suggesting intrinsic curvature in the high-energy spectra of these two AGN. Compilation efforts led by current VHE instruments are of critical importance for target-selection strategies before the advent of the Cherenkov Telescope Array, CTA.
Intrathymic Parathyroid Adenoma Presenting with Seizures

Abstract A 59-year-old diabetic patient was admitted with loss of consciousness and convulsions. Hypercalcaemia and hypoglycaemia were discovered. Computed tomographic and technetium scans revealed a retrosternal paramedian nodule. Radical thymectomy was performed by median sternotomy. Diagnosis of intrathymic parathyroid adenoma was made. One year later the patient had good diabetes control without clinical symptoms.
Secure multi-pair massive MIMO two-way amplify-and-forward relay network with power allocation scheme

Recently, security problems in massive multiple-input multiple-output (MIMO) network draw more and more attention. In this paper, a security problem for a multi-pair massive MIMO two-way amplify-and-forward (AF) relay network is considered, where multiple users exchange confidential messages via a common relay equipped with large number of antennas. We propose an optimal power allocation scheme that maximizes the secrecy sum rate (SSR) under power constraints, when the multi-pair sources act as both potential eavesdroppers who intend to wiretap the information of other pairs and conventional users who exchange their information with pairings. Simulation results show that the proposed scheme outperforms the equal power allocation especially under the circumstance of large number of relay antennas. Furthermore, the number of user-pairs, the Signal to Noise Ratio (SNR) and the number of relay antennas are all factors which influence the performance of SSR in this network.