Miracle-dz/UniFAR-FTUs huggingface dataset:
Computational studies of LXR molecular interactions reveal an allosteric communication pathway

The liver X receptor, LXRα, is an important regulator of genes involved in metabolism and inflammation. The mechanism of communication between the cofactor peptide and the ligand in the ligand‐binding pocket is a crucial and often discussed issue for the nuclear receptors (NRs), but such allosteric signaling pathways are difficult to detect and the transmission mechanism remains elusive. Here, we apply the anisotropic thermal diffusion method to the LXRα with bound coactivator and ligand. We detected a possible communication pathway between the coactivator peptide and the ligand. The signal is transmitted both through the receptor backbone and side chains. A key signaling residue is the first leucine in the cofactor peptide recognition motif LXXLL, which is conserved within the NR cofactors, suggesting a general mechanism for allosteric signaling. Furthermore, we studied the LXR receptor and cofactor molecular interactions in detail using molecular dynamics simulations. The protein–protein interaction patterns in the complexes of nine different cofactor peptides and holo‐LXRα were characterized, revealing the importance of the receptor–cofactor charge clamp interaction. Specific, but infrequently occurring interactions were observed toward the cofactor peptide C‐terminal residues. Thus, additional specificity between LXRα and its cofactors is likely to be found in molecular interactions outside the cofactor peptide or in other biological factors. Proteins 2012;. ©2011 Wiley Periodicals, Inc.
Low-Profile and Wide-Beamwidth Dual-Polarized Distributed Microstrip Antenna

A low-profile and wide-beamwidth dual-polarized distributed microstrip antenna is presented in this paper. Four isolated micro patches are proposed as the radiation components and are excited by a compact differential-fed network. The micro patches in two diagonals determine the operating frequency bands of the two polarizations, respectively. By increasing the distances between the micro patches, the beamwidth in E plane can be broadened. Shorting poles between the patches and the ground plane are used to achieve good impedance matching. Compact dual-polarized differential-fed networks are also studied and compared with achieve the best antenna performance. To validate the proposed method, a wide-beamwith dual-polarized distributed microstrip antenna, whose dual polarizations operate at 2 and 2.2 GHz, respectively, is manufactured and measured. The external dimensions of the antenna is 70mm<inline-formula> <tex-math notation="LaTeX">$\times 10$ </tex-math></inline-formula>mm (<inline-formula> <tex-math notation="LaTeX">$0.49\lambda \times 0.07\lambda$ </tex-math></inline-formula>). The experimental results agree well with the simulated ones. The 3dB beamwidths in E planes reach 116° and 115°, and the gains are 5.15 and 5.5 dB for two polarizations, respectively. Meanwhile, the cross polarizations are less than −26.2 and −27.8 dB. In addition, the impedance bandwidths of 9.2% and 9.9% for VSWR<inline-formula> <tex-math notation="LaTeX">$\leq 2$ </tex-math></inline-formula> are achieved, and the port isolation is greater than 25.4 dB in the bands.
Learning about customers: Managing B2B alliances between small technology startups and industry leaders

Purpose – The aim of this paper is to gain a better understanding of how small technology start‐ups learn about a key customer in the context of B2B relationships, and to propose a model of interfirm learning with customers.Design/methodology/approach – Using a qualitative case‐based approach, the authors immerse themselves in the development of three learning alliances between technology startups and industry leaders, two successes and one failure, to gain an in‐depth understanding of the dynamics involved. Data were collected on both sides of the alliance dyad.Findings – The paper delineates four learning cycles: alliance inception, joint‐learning, specialization and discovery. These learning cycles constitute sequences of increasing understanding, cooperation, and higher order learning between the partners; evolving from an exchange of existing knowledge to the joint development of new knowledge.Originality/value – This study contributes to an integration of the alliance and marketing literatures by of.
Catalytic Wet-oxidation of a Mixed Liquid Waste: COD and AOX Abatement

A series of catalytic wet oxidation (CWO) reactions, at temperatures of 430-500 K and in a batch bench-top pressure vessel were carried out utilizing a strong wastewater composed of landfill leachate and heavily organic halogen polluted industrial wastewater. A CeO2-SiO2 mixed oxide catalyst with large surface area to assure optimal oxidation performance was prepared. The catalytic process was examined during batch reactions controlling Chemical Oxygen Demand (COD) and Adsorbable Organic Halogen (AOX) parameters, resulting AOX abatement to achieve better effect. Color and pH were also controlled during batch tests. A simple first order-two stage reaction behavior was supposed and verified with the considered parameters. Finally an OUR test was carried out to evaluate biodegradability changes of wastewater as a result of the catalytic reaction.
Video Motion: Finding Complete Motion Paths for Every Visible Point

RESEARCH Duke University, Graduate Research Assistant EXPERIENCE Project: Video Motion January 2009 – September 2013 • Recovered fully dense motion trajectories from general video that bridge temporary occlusions and extend over many frames. • Extracted occlusion surfaces using global spatial and temporal information. Project: Fingerspelling Recognition May 2007 – September 2009 • Recognized American Sign Language (ASL) fingerspelling sequences by classifying transitional motions between pairs of letters. • Improved ability to recognize gestures during high-speed, conversational signing.
An Empirical Study on the Intention of Knowledge Buyers and Sellers in a Web 2.0 Knowledge Community ─ Using Taiwan Yahoo! Kimo Knowledge + as the Example

Abstract Internet is becoming a platform for people to exchange information and knowledge, such as Wikipedia, Flickr, Del.icio. us, Yahoo! Answers.com, and Taiwan Yahoo! Kimo Knowledge + , which are identified as Web 2.0. However, little is known about the difference of intention to participate in the platform between knowledge askers and knowledge answerers. Based on TAM, social influence theory and abstraction of knowledge marketplace, we proposed two separate models for knowledge buyers (knowledge askers) and knowledge sellers (knowledge answerers), respectively. Using 403 users of Taiwan Yahoo! Kimo Knowledge + via internet surveying, the results of this paper reveal that the TAM is statistically significant for both models, but the social influence factors tend to be different between gender groups, age groups and education level groups. Finally, the managerial implications and limitations of this research are discussed. Key words: Web 2.0, Knowledge community, Knowledge sharing behavior, Knowledge buyer, Knowledge seller, Technology acceptance model, Social influence theory ____________________________________________________________________________________________1 CollECTeR Iberoamerica 2008
Building a modular YAWL engine with Cumbia

Nowadays, novel strategies to develop and adapt workflow engines in efficient ways are required in order to have BPM and workflow solutions with the capacity to support frequent changes in the corporate environment. One key strategy is to build new engines by reusing as much as possible from existing components. This requires two things. Firstly, the mechanisms and technologies to build a library of reusable, extensible and adaptable workflow components. And secondly, a platform to integrate those components and form full applications. In this paper we show that Cumbia, being a platform for the development of workflow engines based on the modularisation of workflows according to concerns, suits this task. This is illustrated with YOC, a Cumbia-based implementation of YAWL.
Electrodeposition of alginate hydrogel for spatially selective entrapment of biological cells

In this paper, an electrodeposition method was applied to construct cell patterning structures by an alginate hydrogel. The liver cells (RLC-18) were trapped selectively within alginate structures on the micro-patterning electrodes, which were fabricated by a photo-lithography process in circular, ring, and triangle structures. The living conditions of RLC-18 cells were confirmed until 3 days. These results indicate that biological cells were entrapped inside arbitrary shape hydrogel structures in living conditions. The fabricated 2D biological structures are important to be applied for 3D assembly of biological cells for tissue engineering applications.
Corticosteroid pulse the therapy for the treatment of cholesterol embolic disease.

Cholesterol embolic disease, which was initially reported by Flory in 1945 (1), has recently been prevalent. The major outcomes include end-stage renal disease and death (2). The embolization is caused by showers of atherogenic substances having cholesterol crystals when fragile atheromatous plaques in the aorta and large arteries are ruptured by radiological instrumentations, catheter manipulations, surgical treatments or the use of anticoagulant agents (2-4). The embolized vessels are distributed in various organs as well as in the upper and lower extremities. Accordingly, patients have systemic manifestations, e.g., blue toes, claudication and abdominal pain due to intestinal ischemia. The kidney is frequently involved because renal arteries are bifurcated from the abdominal aorta directly and are supplied a large amount of blood. Acute renal failure is the most unfavorable outcome in renal involvement. The main risk factors are older age, male gender, diabetes mellitus, hypertension and smoking (2-4). In addition, the association of preexisting renal impairment may result in poor prognosis. To date, there is no optimal treatment to be curable for this disease (5). In this situation, however, trials of corticosteroid therapy have been reported in several journals (5-8). Actually, it is conceivable that cholesterol crystal embolization induces inflammatory and immunological reactions and leads to vasculitis-like lesions (9, 10). This mechanism may play an important role in renal failure and other fatal organ injuries. Several clinical symptoms, e.g., eosinophilia, hypercomplementemia and increased serum C-reactive pro-
Design and Analysis of a Self-Repairing SRAM with On-Chip Monitor and Compensation Circuitry

In an SRAM array, the systematic inter-die and the random within-die variations in process parameters cause significant number of parametric failures, to degrade process yield in the nanometer technology regime. In this paper, we investigate the interaction between the inter-die and intra-die Vt variations on SRAM read and write failures. To improve robustness of SRAM cell, we propose a closed-loop compensation scheme using on-chip monitors that directly sense the global read stability and writability of the cell directly. Computer simulations based on 45nm PD/SOI technology demonstrate the viability and effectiveness of the scheme in SRAM yield enhancement.
Active Financial Intermediation and Market Efficiency: The Case of Fast-Growing Firms Financed by Venture Capitalists

Financial market dynamics have recently given rise to intermediation in venture capitalism. Today, this is one of the paradigms of finance theories in relation to fastgrowing companies. It is in this framework that we examined how venture capitalists’ active intermediation contributes to enhanced efficiency between capital markets and fast-growing companies. More specifically, we developed an empirical model of the valuation of initial public offerings based on information produced by the company and by venture capitalists. Our findings indicate that venture capitalists fulfil an intermediation role in information production by providing expertise and validating information produced by the company. Moreover, it appears that companies financed by active venture capitalists are less under-valued than companies financed by handsoff venture capitalists.
State Capacity and the Quality of Policies: Revisiting the Relationship between Openness and the Size of Government

The literature has identified that countries with higher levels of openness tend to present a larger government sector as a way to reduce the risks to the economy that openness entails. This paper argues that there are a number of policies that can mitigate trade-induced risks, many of which do not have the necessary implication of increasing public spending. Yet, many such policies require governmental capabilities not available to any country. For that reason, the relationship between openness and the size of government might be mediated by the quality of its public sector. While countries with weak government capabilities will tend to rely on spending expansions to deal with trade-induced volatility, countries with stronger governmental capabilities might address such challenges by more efficient and less costly means. The empirical analysis in this paper shows that the effect of openness on government consumption is mediated by the quality of government institutions.
Early and late nuclei in yes-no questions: tails or high rises?

In this paper we analyze the placement of the nucleus in yesno questions and its significance in American English. We show that the vast majority of positive yes-no questions are expressed through a low rise, often with at least one word as a tail. High rise is the second most common yes-no question nucleus; and so we are interested in the question of why a high-rise instead of a low rise contour is sometimes selected by the speaker. It can be difficult to tell whether a question should end in a late high rise, or whether an early low-rise should be postulated with a tail that is part of the rise. We bring phonetic criteria to bear on this question, and also show that post-nuclear tails tend to consist of function words or else of information that is in some sense given in the discourse. Finally, we present evidence that the discourse function of high rises overlaps with the function of tails to such an extent that it is economical to consider the high pitch accent of a high rise nuclear tune as simply an accented part of what otherwise could be analyzed as a tail.
Conceptualising managerial and leadership wisdom - how many wise managers and leaders do you know?

The term ‘wisdom’ is used frequently in terms of managerial and leadership functioning and development. However, when asked ‘How many wise managers and leaders do you know? ’ most people struggle to firstly name people and secondly, to explain what ‘wise or wisdom’ means because they tend to consider wisdom from a particular paradigm – philosophical, spiritual, cultural, psychological or ethical. This conceptual paper raises different perceptions of the meaning of ‘wisdom’ before broadly critiquing literature that deals with wisdom in terms of philosophical, spiritual, cultural, psychological and ethical constructs. This leads to summations that wisdom is largely contextual –someone might be considered wise in one context but not in another – and that a knowledgeable person is not necessarily a wise person. However, wisdom appears to comprise elements of knowledge, integrity and compassion. The paper then discusses wisdom as an ethical construct in management and leadership and concludes with a conceptual discussion of the vexed question ‘can wisdom be developed? ’
Analysis and Design of Annular Microstrip-Based Planar Periodic Leaky-Wave Antennas

A low-cost leaky-wave antenna using cylindrical surface waves propagating on a grounded dielectric slab is proposed. The excited surface waves are then perturbed into a leaky-wave regime, by the addition of annular microstrip-based (“bull-eye”) gratings. Various surface-wave modes may be considered, however, we desire to achieve radiation from the fundamental TM0 mode due to its zero cutoff frequency and possibility for efficient excitation. A comprehensive design strategy is detailed in the paper. It is based on both an accurate knowledge of the modal spectrum, obtained with the method of moments, and an analysis of the resonant modes supported by the constituent microstrip rings. To further support our methodology, numerical calculations, full-wave simulations, and antenna measurements are reported for the basic structure. Also, additional designs for enhanced gain at broadside, reduced cross-polarization levels, and improved wide-angle frequency beam scanning are presented.
Recommending An Insurance Policy Using Association Rule Mining

Improving the efficiency of ascertaining the frequent itemsets is a crucial issue in association rule mining algorithms. This paper illustrates the use of Apriori algorithm for Life Insurance Corporation for recommending a policy to a customer who is interested in taking a policy. For recommending a policy to a customer, the information about existing policy holders is taken into consideration. This paper also analyzes the performance of “An Improved Apriori Algorithm based on Matrix” [1].
Healthcare ICT and personal data protection: The applicable legal framework

ICT technology and solutions are always more deployed in the healthcare sector, both in the private and in the public sectors. Health related information is sensitive data, which under the law has to be collected and processed in compliance with strict privacy and security requirements. Implementation of ICT technology in the Healthcare sector has therefore to take into careful consideration the applicable privacy and data security legal framework.
Signaling Environment for Service Level Negotiation and QoS management in Mobile IP Networks

This paper describes a signaling environment for service level negotiation and advance resource reservation in mobile IP networks. This environment is built in conformance with the generic signaling environment, which is standardized by the NSIS IETF working group. The service level negotiation protocol, called SLN NSLP, integrates the NSIS architecture to assure, thanks to the negotiation of an SLS, the availability of the resources needed by applications. The advance resource reservation protocol, called MQoS NSLP, is based on the QoS NSLP signaling application. It provides to mobile terminals the QoS required by taken into account the user's mobility and QoS profile. The advance resource reservation is based on an object MSpec (Mobility Specification) which determines the future location of the mobile terminal. The MSpec object which is a part of a mobility and QoS profile, is determined by the mobile terminal.
Control and Value in Mobile Communications: A Political Economy of the Reconfiguration of Business Models in the European Mobile Industry

The emergence of software platforms and internet-like end-to-end architectures in mobile communications systems, as well as the expected breakthrough of a range of alternative wireless network technologies, are causing intense pressure on the dominant technological and business set-up in the mobile industry. A strong current in business and academic literature is arguing that the 'open and modular' internet architectures will (or should) wipe away the current 'closed and integrated' telecommunications architectures. It is often implied that, as a result, (mainly US-based) internet and IT firms are bound to make significant inroads into the telecommunications market. By contrast, others anticipate that the advantages in terms of quality and security offered by integrated telecommunications architectures will allow mobile operators to dominate the mobile internet and to capture a major share of all service revenues in this context. In this PhD thesis, it is hypothesised that there is no automatic mirroring between technical modularity and market unbundling, and that, instead of relying on any outright 'open' or 'closed' strategy, the mobile industry is increasingly bound to employ 'open but not open' platform business models, in order to combine advantages of diversity and complementarity with advantages of control and coordination. A business model is redefined as the 'architecture' of a specific business, i.e. the way in which control and value parameters are balanced within a network of collaborating firms. This approach aims to contribute to the revitalisation of the political economy of ICT (re)design, which stresses that control configurations, power relationships and different forms of bias pervade technological architectures, and that they profoundly influence the individual, societal and economic value generated through these architectures. On the basis of a range of real-life cases as well as two series of in-depth interviews with decision makers and strategists in the European mobile industry, a number of strategically viable business models are identified, and the implications for the set-up of mobile communications are outlined.
A Sub-0.2$^{\circ}/$ hr Bias Drift Micromechanical Silicon Gyroscope With Automatic CMOS Mode-Matching

This paper describes a system architecture and CMOS implementation that leverages the inherently high mechanical quality factor (Q) of a MEMS gyroscope to improve performance. The proposed time domain scheme utilizes the often-ignored residual quadrature error in a gyroscope to achieve, and maintain, perfect mode-matching (i.e., ~ 0 Hz split between the high-Q drive and sense mode frequencies), as well as electronically control the sensor bandwidth. A CMOS IC and control algorithm have been interfaced with a 60 mum thick silicon mode-matched tuning fork gyroscope (M2-mathchar TFG) to implement an angular rate sensing microsystem with a bias drift of 0.16deg/hr. The proposed technique allows microsystem reconfigurability-the sensor can be operated in a conventional low-pass mode for larger bandwidth, or in matched mode for low-noise. The maximum achieved sensor Q is 36,000 and the bandwidth of the microsensor can be varied between 1 to 10 Hz by electronic control of the mechanical frequencies. The maximum scale factor of the gyroscope is 88 mV/deg/s . The 3 V IC is fabricated in a standard 0.6 mum CMOS process and consumes 6 mW of power with a die area of 2.25 mm2.
Contribution of cell culture additives to the two‐dimensional protein patterns of mouse macrophages

Low levels of fetal calf serum (FCS), used as protein supplement in cell culture medium, were traced in preparations of primary murine macrophages (bone‐marrow‐derived macrophages (BMM) and peritoneal macrophages (PM)). Main components of this common additive were mapped in 2‐DE by means of differential image gel electrophoresis and immunoblotting. Additional washing steps in cell preparation helped to decrease the levels of the four highest abundance foetal serum proteins (serum albumin (SA), α1‐fetoprotein (AFP), α1‐antitrypsin (α1AT) and transferrin (Tf)) to less than 1% of total protein. Macrophage spot pattern was recorded in parallel and showed little variation. Results presented are supposed to be of general interest for cell preparations with similar background.