Miracle-dz/UniFAR-FTUs huggingface dataset:
Genome Dissection of Traits Related to Domestication in Azuki Bean (Vigna angularis) and Comparison with other Warm-season Legumes

Background The objective of this study was to dissect into quantitative trait loci (QTLs) the large morphological and physiological differences between cultivated azuki bean (Vigna angularis) and a wild relative and to infer the commonalities of the QTLs for domestication-related traits across the Asian Vigna and with other warm-season legumes. Methods Two linkage maps, for the BC1F1 and F2 populations, respectively, from the same cross between azuki bean and V. nepalensis were developed. Using these linkage maps QTLs for 33 domestication-related traits were analysed and mapped. The location of mapped QTLs was compared with locations of similar QTLs in other warm-season legumes. Key Results QTLs were detected for seed-, pod-, stem- and leaf-related traits. Most traits were controlled by between two and nine QTLs but several traits, such as pod dehiscence, were controlled by single genes. QTLs for domestication-related traits were restricted to particular regions of the azuki bean genome, especially linkage groups 1, 2, 4, 7 and 9. Linkage groups 1 and 2 had QTLs for a suite of traits including pod size, germination, seed size and lower stem length. QTLs on linkage groups 7 and 9 were associated with upper stem length, maximum leaf size and pod and seed size. Pleiotropy or close linkage of genes for domestication-related traits is suggested in these regions. While some QTLs are common to azuki bean and other warm-season legumes, many are recorded for the first time in azuki bean. Conclusions QTLs for a large number of domestication-related traits have been mapped for the first time in azuki bean. QTLs with unexpected effect and new QTLs for traits such as seed size have been found. The results provide a foundation that will be useful for improvement of azuki bean and related legumes.
Exact and conceptual repetition dissociate conceptual memory tests: problems for transfer appropriate processing theory.

Three experiments examined whether a conceptual implicit memory test (specifically, category instance generation) would exhibit repetition effects similar to those found in free recall. The transfer appropriate processing account of dissociations among memory tests led us to predict that the tests would show parallel effects; this prediction was based upon the theory's assumption that conceptual tests will behave similarly as a function of various independent variables. In Experiment 1, conceptual repetition (i.e., following a target word [e.g., puzzles] with an associate [e.g., jigsaw]) did not enhance priming on the instance generation test relative to the condition of simply presenting the target word once, although this manipulation did affect free recall. In Experiment 2, conceptual repetition was achieved by following a picture with its corresponding word (or vice versa). In this case, there was an effect of conceptual repetition on free recall but no reliable effect on category instance generation or category cued recall. In addition, we obtained a picture superiority effect in free recall but not in category instance generation. In the third experiment, when the same study sequence was used as in Experiment 1, but with instructions that encouraged relational processing, priming on the category instance generation task was enhanced by conceptual repetition. Results demonstrate that conceptual memory tests can be dissociated and present problems for Roediger's (1990) transfer appropriate processing account of dissociations between explicit and implicit tests.
Adaptive Fuzzy Inference System for Induction Motor Slip Control

In this paper a Fuzzy Logic Controller (FLC) is proposed for slip minimization and efficiency optimization for the induction motor. Two independent fuzzy logic controllers (FLCs) are implemented using ANFIS toolbox in Matlab Simulink environment. The first FLC is used to control the speed by taking the speed and the speed dervative as input to minimize the motor slip. The second FLC is used to search the minimum power in order obtain the optimized efficiency. A comparative study of this fuzzy logic based adaptive controller with a conventional PI controller is implemented in this paper. Simulated results show that the proposed controller provides high-performance dynamic characteristics and is robust with regard to plant parameter variations and external load disturbance.
A novel hybrid electromagnetism-like algorithm for solving the inverse kinematics of robot

Purpose – This paper aims to develop a new real‐time effective method for solving the inverse kinematics (IK) problem, especially for those manipulators with high‐dimensional nonlinear kinematic equations.Design/methodology/approach – The paper transforms the IKs problem into a minimization problem. Then, a novel meta‐heuristic algorithm, called the electromagnetism‐like method (EM), is used to solve this equivalent problem. Moreover, in order to further improve the computational efficiency and accuracy of EM, a hybrid method which combines EM with the Davidon‐Fletcher‐Powell (DFP) method is proposed.Findings – The results showed that EM is a powerful yet easy algorithm for solving the IKs problem of robot manipulators. Its complexity is independent on the characteristics of the kinematic equations involving dimensionality and the degree of nonlinearity. Moreover, EM can be used as an accompanying algorithm for DFP method to get better precision at a lower iteration number.Originality/value – The method d.
Nonenzymatic glycation of high‐density lipoprotein impairs its anti‐inflammatory effects in innate immunity

In type 2 diabetes mellitus (T2DM), the abnormal protein and lipid composition of diabetic high‐density lipoprotein (HDL) could impair its anti‐inflammatory functions. Whether nonenzymatic glycation directly impaired the anti‐inflammatory effects of HDL in innate immunity remained unclear.
The changing pattern of admissions to a London hospital of patients with HIV: 1988-1997. Royal Free Centre for HIV Medicine.

OBJECTIVE To describe the changes over time in incidence of hospital admissions among patients with HIV, reasons for hospital admission, duration of stay, relationship with CD4 T-cell count and with antiretroviral treatment. METHODS The incidence of hospital admissions during each calendar year from 1988 to 1997 inclusive was calculated using a person-years analysis. In addition the proportion of patient follow-up spent in hospital and the impact of changing treatment regimens among all patients with HIV aged > or = 14 years and with at least one CD4 T-cell count seen at the Royal Free Hospital, London was also described. RESULTS A total of 1806 patients were investigated with median follow-up of 21.1 months. Among all patients, the proportion of follow-up time spent as an in-patient decreased from 3.9% in 1988 to 1.3% in 1997 (P = 0.0015; test for trend). Hospital admissions for any cause peaked during 1989 at 72.0 per 100 patient years of follow-up (PYFU) and was 28.5 per 100 PYFU during 1997 (P < 0.0001; test for trend). There was a statistically significant decline in the proportion of follow-up time spent as an in-patient among patients with CD4 T-cell counts of < 50 x 10(6)/l from > 30% before 1990 to < 5% during 1997 (P = 0.026; test for trend). Hospital admissions varied greatly according to treatment regimen; in 1996 and 1997 just 0.1% of follow-up time of patients on triple antiretroviral treatment regimens was spent as a hospital admission. CONCLUSIONS Admissions to hospital began falling before the introduction of combination therapy and declined strikingly during 1996 and 1997 following the introduction of highly active antiretroviral therapy. These results have important implications for future allocation of resources and for patient management.
Motor impairment in PD

Objective: To analyze the relationship of specific motor impairment in idiopathic PD to incident dementia. Background: The total Unified PD Rating Scale (UPDRS) motor score at baseline has been associated with an increased risk of developing dementia in PD. Methods: A cohort of 214 nondemented community-dwelling patients with PD was followed annually with neurologic and neuropsychological evaluations. The association of baseline motor impairment with incident dementia was analyzed using Cox proportional hazards models. Facial expression, tremor, rigidity, and bradykinesia were analyzed as part of subscore A (indicative of dopaminergic deficiency); speech and axial impairment were analyzed as part of subscore B (indicative of predominantly nondopaminergic deficiency). The correlation between the six motor domains and age was also analyzed. Results: Of 173 patients followed for at least 1 year, 50 became demented according to the Diagnostic and Statistical Manual of Mental Disorders, revised 3rd edition (DSM III-R) criteria (mean follow-up, 3.6 ± 2.2 years). When both subscores A and B were entered into the Cox model, subscore B was associated with incident dementia (relative risk = 1.19; 95% CI, 1.09 to 1.30; p = 0.0001), in addition to gender, age, and education, whereas subscore A was not (relative risk = 1.03; 95% CI, 0.99 to 1.07; p = 0.19). Of the six motor domains, speech and bradykinesia were associated with incident dementia (p < 0.05), and axial impairment approached significance (p = 0.06). Only axial impairment was correlated with age (correlation coefficient = 0.32; p < 0.001). Conclusion: The findings suggest that motor impairment mediated predominantly by nondopaminergic systems is associated with incident dementia in PD. Axial impairment may be the result of a combined effect of the disease and the aging process.
Traditional studying for examination versus constructivist learning tasks: Do learning outcomes differ?

ABSTRACT Students' learning outcomes on an educational psychology course which involved studying three textbooks were compared between a constructivist class without a final examination and a traditional class concluding with an examination. The constructivist group (n = 16) studied the coursebooks with the help of writing assignments, discussed their assignments in groups and wrote an essay. The control group (n = 23) read the books on their own, attended lectures and took an examination. Learning outcomes were investigated (1) as the students' subjective learning experiences; (2) as changes in the students' learning conceptions; and (3) as measured by a traditional examination in which the students had to answer two questions. Although the constructivist group students did not have to take the examination as a basis of their course grade, they were asked to answer the questions in order to provide research material. All students in both groups described their learning in terms of knowledge acquisition.
Near-capacity BICM-ID for MIMO channels

Bit-interleaved coded modulation with iterative demapping (BICM-ID) is investigated for multiple-input multiple-output (MIMO) channels. Based on the average mutual information (AMI) analysis, vertical Bell-lab layered space-time (V-BLAST) rather than space-time block code (STBC) is chosen to be combined with BICM-ID. Based on the extrinsic information transfer (EXIT) chart analysis, a novel algorithm in searching for a labeling to well match the outer code is proposed for MIMO channels, which facilitates a near-capacity V-BLAST-BICM-ID scheme. Computer simulation confirmed the near-capacity performance.
A non-linear autoregressive neural network model for forecasting Indian index of industrial production

For a developing country such as India, to have the best usage of resources, public planning requires good forecasts of future trends. India's Index of Industrial Production (IIIP) is an index which conveys the status of production in the industrial sector of the economy. In this study, an artificial neural network (ANN) was applied to forecast IIIP. Accordingly, the inputs to the ANN consisted of data spanning from F.Y. 2004–05 to F.Y. 2013–14 of Gross Domestic Product (GDP), Consumer Price Index (CPI), Wholesale Price Index (WPI) and Index of the Eight Core Industries (Electricity, Steel, Refinery Products, Crude Oil, Coal, Cement, Natural Gas and Fertilizers) to forecast IIIP. Therefore, a methodology for forecasting was developed using Nonlinear Autoregressive (NAR) and Nonlinear Autoregressive neural network with exogenous inputs (NARX) models. Several structures of the neural networks were tested for forecasting, and then the results were compared in terms of forecasting error. The NARX network with 11 hidden layers and 1 delay line provided the best results with a Mean Square Error (MSE) of 2.168. Thus, ANNs can be used for accurate forecasting of Industrial Production.
Developing a Correlation Index to Identify Coordinated Cyber-Attacks to Power Grids

Increasing reliance on Information and Communication Technology~(ICT) exposes the power grid to cyber-attacks. In particular, Coordinated Cyber-Attacks (CCAs) are considered highly threatening and difficult to defend against, because they (i) possess higher disruptiveness by integrating greater resources from multiple attack entities, and (ii) present heterogeneous traits in cyber-space and the physical grid by hitting multiple targets to achieve the attack goal. Thus, and as opposed to independent attacks, whose severity is limited by the power grid's redundancy, CCAs could inflict disastrous consequences, such as blackouts. In this paper, we propose a method to develop Correlation Indices to defend against CCAs on static control applications. These proposed indices relate the targets of CCAs with attack goals on the power grid. Compared to related works, the proposed indices present the benefits of deployment simplicity and are capable of detecting more sophisticated attacks, such as measurement attacks. We demonstrate our method using measurement attacks against Security Constrained Economic Dispatch.
Divorce, conflict and mental health: how the quality of intimate relationships is linked to post-divorce well-being

Partner relationships, including new relationships after divorce, are found to be beneficial for mental health. However, the impact of their quality remains unclear; this uncertainty applies to past and ongoing relationships between ex-spouses as well. We study the relationship between conflict—in the prior marriage, with the ex-partner, with a new partner—and both positive and negative mental health. Multilevel linear models are carried out on a subsample of 892 divorcees from the dataset “Divorce in Flanders. ” Living together with a new partner, either in marriage or cohabitation, seems beneficial for mental health, even in cases of (high) conflict. Nevertheless, conflict places a burden on well-being, especially for women in non-marital relationships. Ongoing conflict with the ex-spouse is also damaging for mental health. In contrast, prior marital conflict does not relate to lower, but to slightly higher, levels of life satisfaction after divorce.
Specification of Drosophila Corpora Cardiaca Neuroendocrine Cells from Mesoderm Is Regulated by Notch Signaling

Drosophila neuroendocrine cells comprising the corpora cardiaca (CC) are essential for systemic glucose regulation and represent functional orthologues of vertebrate pancreatic α-cells. Although Drosophila CC cells have been regarded as developmental orthologues of pituitary gland, the genetic regulation of CC development is poorly understood. From a genetic screen, we identified multiple novel regulators of CC development, including Notch signaling factors. Our studies demonstrate that the disruption of Notch signaling can lead to the expansion of CC cells. Live imaging demonstrates localized emergence of extra precursor cells as the basis of CC expansion in Notch mutants. Contrary to a recent report, we unexpectedly found that CC cells originate from head mesoderm. We show that Tinman expression in head mesoderm is regulated by Notch signaling and that the combination of Daughterless and Tinman is sufficient for ectopic CC specification in mesoderm. Understanding the cellular, genetic, signaling, and transcriptional basis of CC cell specification and expansion should accelerate discovery of molecular mechanisms regulating ontogeny of organs that control metabolism.
Computing Pareto‐Optimal Predictor Composites for Complex Selection Decisions

A complex selection situation encompasses vacancies for several different positions and applicants that apply simultaneously for one or several of these positions. This article presents an analytic method for estimating the expected selection quality, as well as the adverse impact ratio of these complex selections, when the decisions are based on a single predictor composite score. In addition, the method is integrated within a broader decision-making framework for designing complex selection decisions that show a Pareto-optimal balance between the selection quality and diversity goals. Finally, the decision aid is used to demonstrate the importance of applying the appropriate selection format (either the simple or the complex format) when exploring the front of Pareto-optimal outcomes of planned selections.
Clinicopathological Characteristics and Prognosis-Related Factors of Resectable Pancreatic Neuroendocrine Tumors

Objective The purpose was to describe the clinicopathological characteristics of pancreatic neuroendocrine tumors (pNETs) and evaluate prognosis-related factors in potentially resectable pNETs. Methods The clinical data of 104 patients with pNETs who underwent surgery were retrospectively analyzed. Results The mean (SD) age was 49.8 (14.6) years. The percentages of TNM stages I, II, III, and IV tumors were 25.0%, 44.2%, 22.1%, and 8.7%, respectively. Twenty-seven cases were functional. Nonfunctional pNETs were more common in patients with large tumors, advanced age, higher mitotic count, neural invasion, extrapancreatic organ invasion, liver metastases, and advanced staging (P < 0.05). The 5-year overall survival rate was 93%. The relapse rate was 28.6% (28/98), and the mean (SD) relapse time was 38.7 (31.7) months. Reduced survival rate was associated with older patients (>60 years) (P = 0.026), patients with a higher Ki-67 index (>2%) (P = 0.024), regional lymph node metastases (P = 0.033), liver metastases (P = 0.015), neural invasion (P = 0.017), necrosis (P = 0.042), and major vascular invasion (P = 0.023). Age of more than 60 years (P = 0.047; hazard ratio [HR], 5.2), major vascular invasion (P = 0.030; HR, 5.8), and a Ki-67 index greater than 2% (P = 0.008; HR, 10.3) were independent predictors. Conclusions Nonfunctional pNETs were more common with aggressive clinical presentation. Age of more than 60 years, major vascular invasion, and a Ki-67 index greater than 2% were independent predictive factors. Patients who underwent a potentially curative resection seemed to achieve long-term survival.
Effective Employee Performance through Enhanced Agreeableness and Self-image

Fast and frequent change in technology has put the present day employee under pressure. This pressure has impact on employeeâ€™s personality dimensions and consequently on employeeâ€™s performance. So, one of the most critical issue of modern era is to study the impact of changing psychological dimensions on employeeâ€™s performance. This research was aimed to study effects of improved psychological traits like self image and agreeableness on employee performance. Statistical universe for this study was the employees having experience of more than three years from governmental and non-governmental organizations. Employee Performance, Agreeableness and self image among managers were assessed by using the employee performance inventory developed by researchers, Agreeableness Measuring Scale (AMS) (Rishipal and Jain, N., 2012) and The State Self-Esteem scale (SSES) (Heatherton and Policy, 1991) respectively. A cross-sectional and longitudinal study was conducted by using the before and after with control group research design to compare the performance of treatment group consisting of the low performer employees having lower tendency of agreeableness and self-image and control group consisting of the high performer employees having higher tendency of agreeableness and self-image. Control and treatment group were formed by adopting the sampling technique of randomization on availability basis. Before treatment both the control and treatment group were tested. The mean scores for employee performance (EP), agreeableness (Ag.) and self-image (SI) for control group were 24.27, 213.76 and 79.69 respectively whereas the mean scores of test group before treatment for employee performance (EP), agreeableness (Ag.) and self-image (SI) were 10.28, 90.23 and 33.98 respectively. There was significant difference between the pre and post treatment mean scores values of Employee Performance (Meanpre-treatment = 10.28 and Meanpost-treatment = 23.57), Agreeableness (Meanpre-treatment = 90.23
Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro

Benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) are added to bodycare cosmetics used around the human breast. We report here that all three compounds possess oestrogenic activity in assays using the oestrogen‐responsive MCF7 human breast cancer cell line. At 3 000 000‐fold molar excess, they were able to partially displace [3H]oestradiol from recombinant human oestrogen receptors ERα and ERβ, and from cytosolic ER of MCF7 cells. At concentrations in the range of 5 × 10−5 to 5 × 10−4 m, they were able to increase the expression of a stably integrated oestrogen‐responsive reporter gene (ERE‐CAT) and of the endogenous oestrogen‐responsive pS2 gene in MCF7 cells, albeit to a lesser extent than with 10−8 m 17β‐oestradiol. They increased the proliferation of oestrogen‐dependent MCF7 cells over 7 days, which could be inhibited by the antioestrogen fulvestrant, suggesting an ER‐mediated mechanism. Although the extent of stimulation of proliferation over 7 days was lower with these compounds than with 10−8 m 17β‐oestradiol, given a longer time period of 35 days the extent of proliferation with 10−4 m benzyl salicylate, benzyl benzoate or butylphenylmethylpropional increased to the same magnitude as observed with 10−8 m 17β‐oestradiol over 14 days. This demonstrates that benzyl salicylate, benzyl benzoate and butylphenylmethylpropional are further chemical components of cosmetic products which give oestrogenic responses in a human breast cancer cell line in culture. Further research is now needed to investigate whether oestrogenic responses are detectable using in vivo models and the extent to which these compounds might be absorbed through human skin and might enter human breast tissues. Copyright © 2009 John Wiley & Sons, Ltd.
Wage Floors, Imperfect Performance Measures, and Optimal Job Design

We analyze the effects of wage floors on optimal job design in a moral-hazard model with asymmetric tasks and imperfect aggregate performance measurement. Due to cost advantages of specialization, assigning the tasks to different agents is efficient. A sufficiently high wage floor, however, induces the principal to dismiss one agent or to even exclude tasks from the production process. Imperfect performance measurement always lowers profit under multitasking, but may increase profit under specialization. We further show that variations in the wage floor and the agents' reservation utility have significantly different effects on welfare and optimal job design.