Miracle-dz/UniFAR-FTUs huggingface dataset:
Visible Light-Cured Glycol Chitosan Hydrogel Containing a Beta-Cyclodextrin-Curcumin Inclusion Complex Improves Wound Healing In Vivo

Scarless wound healing is ideal for patients suffering from soft tissue defects. In this study, we prepared a novel wet dressing (β-CD-ic-CUR/GC) based on the visible light-cured glycol chitosan (GC) hydrogel and inclusion complex between beta-cyclodextrin (β-CD) and curcumin (CUR). We also evaluated its efficacy in the acceleration of wound healing as compared to that of CUR-loaded GC (CUR/GC). The conjugation of glycidyl methacrylate (GM) to GC for photo-curing was confirmed by 1H-NMR measurement, and the photo-cured GC hydrogel was characterized by the analyses of rheology, swelling ratio, SEM and degradation rate. After visible light irradiation, the surface/cross-sectional morphologies and storage (G′)/loss (G′′) moduli revealed the formation of hydrogel with interconnected porosity. The dressing β-CD-ic-CUR/GC exhibited a controlled release of 90% CUR in a sustained manner for 30 days. On the other hand, CUR/GC showed CUR release of 16%. β-CD acted as an excipient in improving the water-solubility of CUR and affected the release behavior of CUR. The in vivo animal tests including measurement of the remaining unhealed wound area and histological analyses showed that β-CD-ic-CUR/GC may have potential as a wet dressing agent to enhance soft tissue recovery in open fractures.
Predictable factors for dural tears in lumbar burst fractures with vertical laminar fractures.

OBJECTIVE The purpose of the present study was to determine the incidence of dural tears and predictable factors suggesting dural tears in patients who had lumbar burst fractures with vertical laminar fractures. METHODS A retrospective review was done on thirty-one patients who underwent operative treatment for lumbar burst fractures with vertical laminar fractures between January 2003 and December 2008. All patients were divided into two groups according to existence of dural tears, which were surgically confirmed; 21 patients with dural tears and 10 patients without dural tears. Clinical and radiographic findings were analyzed for their association with dural tears. RESULTS Among a total of 31 patients, dural tears were detected in 21 (67%) patients. A preoperative neurological deficits and mean separation distances of the edges in laminar fractures were found to be the reliable factors of dural tears (p=0.001 and 0.002, respectively). Decreased ratio of the central canal diameter and interpedicular distance were also the reliable factors suggesting dural tears (p=0.006 and 0.015, respectively). However, dural tears showed no significant association with age, sex, level of injury, absence of a posterior fat pad signal, the angle of retropulsed segment, or site of laminar fracture. CONCLUSION Our study of lumbar burst fracture combined laminar fracture revealed that dural tears should be ruled out in cases of a preoperative neurological deficits, wide separation of the laminar fracture, severe canal encroachment, and wider interpedicular distance.
Local Morphological Response Following a Single Subcutaneous Injection of Carrageenin in the Rat

Summary 1. A single subcutaneous injection of carrageenin in rats caused a local tissue response, which from the 1st through the 4th day could be defined as an inflammatory lesion in the form of an acute abscess, which later (5th through the 28th day) was gradually transformed into a polysaccharide-containing granuloma. 2. Weight data indicate a maximum exudative response after 24 hours.
Effects of Attention on Visible and Invisible Adapters

It has been shown that attention can modulate the processing of a stimulus, even when it is invisible (Bahrami, Carmel, Walsh, Rees, & Lavie, 2008, Perception, 37, 1520–1528). Previous studies, however, investigated the effect of spatial attention on the processing of only invisible items. Thus, it remains unclear how the effect of spatial attention is distributed over visible and invisible items when these items are simultaneously attended at the same location. In the present study we addressed this question using two types of adapters, one visible and one invisible, and compared how attention affected the processing of each adapter. Moving gratings and tilted gratings were presented to each eye; the moving ones were dominant over the tilted ones. Both types of stimuli were located on the left and right sides of a fixation cross, and the participants performed a task that modulated their attention to one side or the other. In experiment 1 they were asked to detect the contrast decrement of one of the moving gratings, and in experiment 2 they detected a dot that was presented to both eyes. We found that attention increased the amount of motion aftereffects induced by the visible adapters. However, we did not find effects of attention on tilt aftereffects from the invisible adapters. Finally, in experiment 3 we found that attention successfully increased the amount of tilt aftereffects when the adapters were not suppressed. These findings suggest that spatial attention is more likely to influence visible items than invisible items in the same location. We also found that invisible items do not interfere with the attentional modulation of the processing of visible items.
Information, social support and anxiety before gastrointestinal endoscopy.

OBJECTIVES To examine Lazarus and Folkman's (1984) stress theory regarding the effects of the stress mediators information and perceived social support on anxiety (as the stress response) regarding gastrointestinal (GI) endoscopy (as the stressor) in male and female patients of various age groups. DESIGN Non-experimental design. METHODS Structured interviews were conducted with 113 hospital out-patients about to undergo GI endoscopy. Participants indicated their perceptions of how much support and how much clear and useful information they had received from both their general practitioner (GP) and a patient information leaflet developed in collaboration with health psychologists as well as their perceptions of how much social support they had obtained from other patients, family and friends. Anxiety was measured with a population-specific trait and state adaptation of the Hospital anxiety and depression scale (HADS-A). RESULTS Psychometric exploration of the HADS-A revealed a single general anxiety factor. The reliability of this factor was high, with Cronbach's alpha=0.91. The majority of the sample experienced high anxiety levels. Gender, but not age, differences emerged, showing females to be more anxious than males, F(1, 84)=5.68, p<. 05. A regression model built on stress theory was tested, with anxiety as the dependent variable and 11 predictor variables. The model was significant with R(2)=0.452, F(11, 47)=3.522 and p=0.001. CONCLUSIONS The clarity, but not the amount, of information and social support from important others, but not GPs, were both mediating the stress experience of the patients by reducing their perceived anxiety.
HYPERSENSITIVE TO HIGH LIGHT1 Interacts with LOW QUANTUM YIELD OF PHOTOSYSTEM II1 and Functions in Protection of Photosystem II from Photodamage in Arabidopsis[C][W][OPEN]

This work identified the thylakoid protein HYPERSENSITIVE TO HIGH LIGHT1 (HHL1), specifically conserved in land plants, as an important regulator of photosynthesis and photoprotection. Together with LOW QUANTUM YIELD OF PHOTOSYSTEM II1, HHL1 regulates the repair and reassembly of photosystem II complex under high-light conditions in Arabidopsis. Under high-irradiance conditions, plants must efficiently protect photosystem II (PSII) from damage. In this study, we demonstrate that the chloroplast protein HYPERSENSITIVE TO HIGH LIGHT1 (HHL1) is expressed in response to high light and functions in protecting PSII against photodamage. Arabidopsis thaliana hhl1 mutants show hypersensitivity to high light, drastically decreased PSII photosynthetic activity, higher nonphotochemical quenching activity, a faster xanthophyll cycle, and increased accumulation of reactive oxygen species following high-light exposure. Moreover, HHL1 deficiency accelerated the degradation of PSII core subunits under high light, decreasing the accumulation of PSII core subunits and PSII–light-harvesting complex II supercomplex. HHL1 primarily localizes in the stroma-exposed thylakoid membranes and associates with the PSII core monomer complex through direct interaction with PSII core proteins CP43 and CP47. Interestingly, HHL1 also directly interacts, in vivo and in vitro, with LOW QUANTUM YIELD OF PHOTOSYSTEM II1 (LQY1), which functions in the repair and reassembly of PSII. Furthermore, the hhl1 lqy1 double mutants show increased photosensitivity compared with single mutants. Taken together, these results suggest that HHL1 forms a complex with LQY1 and participates in photodamage repair of PSII under high light.
Prevalence of Prior Cancer Among Persons Newly Diagnosed With Cancer: An Initial Report From the Surveillance, Epidemiology, and End Results Program

Importance The US cancer survivor population is rapidly growing. Cancer survivors are frequently excluded from cancer clinical trials and observational research. Objective To examine prevalence of prior cancer among individuals newly diagnosed with cancer. Design, Setting, and Participants Linked observations across the population-based Surveillance, Epidemiology, and End Results (SEER) program of cancer registries (1975-2013) for 740 990 persons newly diagnosed with cancer from January 2009 through December 2013. Prevalence of prior cancer was estimated by age (<65 years vs ≥65 years) and incident cancer type. Main Outcomes and Measures Prevalence of prior cancer was derived from SEER sequence numbers, which represent the order of all primary reportable tumors diagnosed in a lifetime. Incident cancers were categorized as: (1) first or only primary; (2) second order or higher primary in the same cancer site; and (3) second order or higher primary in a different cancer site. Results Of 765 843 incident cancers diagnosed between 2009 and 2013, 141 021 (18.4%) represented a second order or higher primary cancer. Overall, approximately one-fourth (25.2%) of older (≥65 years) and 11% of younger adults newly diagnosed with cancer had a history of prior cancer. Prevalence of prior cancer ranged from 3.5% to 36.9% according to incident cancer type and age, with most prior cancers diagnosed in a different cancer site. Conclusions and Relevance A substantial proportion of patients diagnosed with incident cancer in the United States have survived a prior cancer. These patients may be excluded from clinical trials and underrepresented in observational research, and little is known about their treatment and survivorship needs. Understanding the nature and impact of prior cancer is critical to improving clinical trial accrual and generalizability, disease outcomes, and patient experience.
Effect of Ferroelectric Damping on Dynamic Characteristics of Negative Capacitance Ferroelectric MOSFET

Static Landau theory has been widely used to confirm negative capacitance ferroelectric MOSFET (FeFET) as a low power switch with sub-60-mV/decade subthreshold swing. However, dynamic switching considering damping effect in ferroelectrics is rarely evaluated. Based on Landau-Khalatnikov theory, dynamic FeFET characteristics are obtained. For experimentally extracted Pb(Zr0.2Ti0.8)O3 (PZT) damping constant ξFE = 75 Ω · m, the amplified gate capacitance induced by negative capacitance occurs when frequency is below a few MHz for large ξFE. For transient simulation, IDS exhibits a slow response to the rapid change of VG so that the hysteretic IDS-VG curve is generated. Furthermore, inverter prediction with complementary FeFETs shows that the dynamic short circuit switching power is much higher than the static one. These results are attributed to the large PZT response time in comparison with the operation period. For a guidance on ferroelectric selection and improvement, a wide range of damping constants are used to predict the corresponding maximum operation frequency, within which the dynamic and static responses of FeFETs are the same. It indicates that the ferroelectrics with low damping constant are essential to utilize FeFET advantages in high-frequency circuit applications.
A Unique Heparin-Binding Domain in the Envelope Protein of the Neuropathogenic PVC-211 Murine Leukemia Virus May Contribute to Its Brain Capillary Endothelial Cell Tropism

ABSTRACT Previous studies from our laboratory demonstrated that PVC-211 murine leukemia virus (MuLV), a neuropathogenic variant of Friend MuLV (F-MuLV), had undergone genetic changes which allowed it to efficiently infect rat brain capillary endothelial cells (BCEC) in vivo and in vitro. Two amino acid changes from F-MuLV in the putative receptor binding domain (RBD) of the envelope surface protein of PVC-211 MuLV (Glu-116 to Gly and Glu-129 to Lys) were shown to be sufficient for conferring BCEC tropism on PVC-211 MuLV. Recent examination of the unique RBD of PVC-211 MuLV revealed that the substitution of Lys for Glu at position 129 created a new heparin-binding domain that overlapped a heparin-binding domain common to ecotropic MuLVs. In this study we used heparin-Sepharose columns to demonstrate that PVC-211 MuLV, but not F-MuLV, can bind efficiently to heparin and that one or both of the amino acids in the RBD of PVC-211 MuLV that are associated with BCEC tropism are responsible. We further showed that heparin can enhance or inhibit MuLV infection and that the mode of action is dependent on heparin concentration, sulfation of heparin, and the affinity of the virus for heparin. Our results suggest that the amino acid changes that occurred in the envelope surface protein of PVC-211 MuLV may allow the virus to bind strongly to the surface of BCEC via heparin-like molecules, increasing the probability that the virus will bind to its cell surface receptor and efficiently infect these cells.
Okazaki fragment processing: Modulation of the strand displacement activity of DNA polymerase δ by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1

DNA polymerase (pol) δ is essential for both leading and lagging strand DNA synthesis during chromosomal replication in eukaryotes. Pol δ has been implicated in the Okazaki fragment maturation process for the extension of the newly synthesized fragment and for the displacement of the RNA/DNA segment of the preexisting downstream fragment generating an intermediate flap structure that is the target for the Dna2 and flap endonuclease-1 (Fen 1) endonucleases. Using a single-stranded minicircular template with an annealed RNA/DNA primer, we could measure strand displacement by pol δ coupled to DNA synthesis. Our results suggested that pol δ alone can displace up to 72 nucleotides while synthesizing through a double-stranded DNA region in a distributive manner. Proliferating cell nuclear antigen (PCNA) reduced the template dissociation rate of pol δ, thus increasing the processivity of both synthesis and strand displacement, whereas replication protein A (RP-A) limited the size of the displaced fragment down to 20–30 nucleotides, by generating a “locked” flap DNA structure, which was a substrate for processing of the displaced fragment by Fen 1 into a ligatable product. Our data support a model for Okazaki fragment processing where the strand displacement activity of DNA polymerase δ is modulated by the concerted action of PCNA, RP-A and Fen 1.
Microarray Data Analysis of Mouse Neoplasia

Microarray gene expression analysis offers great promise to help us understand the molecular events of experimental carcinogenesis, but have such promises been fulfilled? Studies of gene expression profiles of rodent are being published and demonstrate that yes, indeed, gene array data is furthering our understanding of tumor biology. Recent studies have identified differentially expressed genes in rodent mammary, colon, lung, and liver tumors. Although relatively few genes on the rodent arrays have been fully characterized, information has been generated to better identify signatures of histologic type and grade, understand invasion and metastasis, identify candidate biomarkers of early development, identify gene networks in carcinogenesis, understand responses to therapy, and decifer overlap with molecular events in human cancers. Data from mouse lung, mammary gland, and liver tumor studies are reviewed as examples of how to approach and interpret gene array data. Methods of gene array data analysis were also applied for discovery of genes involved in the regression of mouse liver tumors induced by chlordane, a nongenotoxic murine hepatocarcinogen. Promises are beginning to be fulfilled and it is clear that pathologists and toxicologists, in collaboration with molecular biologists, bioinformatists, and other scientists are making great strides in the design, analysis, and interpretation of microarray data for cancer studies.
Cost of Hospital-Acquired Infection

Abstract The authors assessed the costs of hospital-acquired infections using rigorous econometric methods on publicly available data, controlling for the interdependency of length of stay and the incidence of hospital acquired infection, and estimated the cost shares of different payers. They developed a system of equations involving length of stay, incidence of infection, and the total hospital care cost to be estimated using simultaneous equations system. The main data came from the State of New Jersey UB 92 for 2004, complimented with data from the Annual Survey of Hospitals by the American Hospital Association and the Medicare Cost Report of 2004. The authors estimated that an incidence of hospital acquired infection increases the hospital care cost of a patient by $10,375 and it increases the length of stay by 3.30 days, and that a disproportionately higher portion of the cost is attributable to Medicare. They conclude that reliable cost estimates of hospital-acquired infections can be made using publicly available data. Their estimate shows a much larger aggregate cost of $16.6 billion as opposed to $5 billion reported by the Centers for Disease Control and Prevention but much less than $29 billion as reported elsewhere in the literature.
Study and simulation of an intelligent electrical power subsystem for ERPSat-1 cube satellite

With the continuous interest on space technologies development, small satellites especially pico satellites were the focus of universities research in order to demonstrate the use of these vehicles for communication, earth observation, space remote sensing, space exploration, cartography, forest observation, etc. Despite of the new miniaturization technologies, the electrical power subsystem still the most critical module in pico satellites which basic tasks are to ensure maximum exploitation of energy sources and optimize the distribution of the available electrical power. In this context, this paper proposes a novel architecture of an electrical power subsystem to be used for ERPSat-1 pico satellite which is under development at the Research Group of Intelligent Machines laboratory in Tunisia. This subsystem is basically composed of a Fuzzy Maximum Power Point Tracker, a power conditioner and a hierarchical fuzzy subsystems controller.
LDSScanner: Exploratory Analysis of Low-Dimensional Structures in High-Dimensional Datasets

Many approaches for analyzing a high-dimensional dataset assume that the dataset contains specific structures, e.g., clusters in linear subspaces or non-linear manifolds. This yields a trial-and-error process to verify the appropriate model and parameters. This paper contributes an exploratory interface that supports visual identification of low-dimensional structures in a high-dimensional dataset, and facilitates the optimized selection of data models and configurations. Our key idea is to abstract a set of global and local feature descriptors from the neighborhood graph-based representation of the latent low-dimensional structure, such as pairwise geodesic distance (GD) among points and pairwise local tangent space divergence (LTSD) among pointwise local tangent spaces (LTS). We propose a new LTSD-GD view, which is constructed by mapping LTSD and GD to the <inline-formula><tex-math notation="LaTeX">$x$</tex-math><alternatives><inline-graphic xlink:href="24tvcg01-xia-2744098-ieq-1-source.gif"/></alternatives></inline-formula> axis and <inline-formula><tex-math notation="LaTeX">$y$</tex-math><alternatives><inline-graphic xlink:href="24tvcg01-xia-2744098-ieq-2-source.gif"/></alternatives></inline-formula> axis using 1D multidimensional scaling, respectively. Unlike traditional dimensionality reduction methods that preserve various kinds of distances among points, the LTSD-GD view presents the distribution of pointwise LTS (<inline-formula><tex-math notation="LaTeX">$x$</tex-math><alternatives><inline-graphic xlink:href="24tvcg01-xia-2744098-ieq-3-source.gif"/></alternatives></inline-formula> axis) and the variation of LTS in structures (the combination of <inline-formula><tex-math notation="LaTeX">$x$</tex-math><alternatives><inline-graphic xlink:href="24tvcg01-xia-2744098-ieq-4-source.gif"/></alternatives></inline-formula> axis and <inline-formula><tex-math notation="LaTeX">$y$</tex-math><alternatives><inline-graphic xlink:href="24tvcg01-xia-2744098-ieq-5-source.gif"/></alternatives></inline-formula> axis). We design and implement a suite of visual tools for navigating and reasoning about intrinsic structures of a high-dimensional dataset. Three case studies verify the effectiveness of our approach.
Nucleotide sequence of the Barmah Forest virus genome.

Barmah Forest virus (BFV) is an atypical alphavirus [Dalgarno, L. , Short, N. J., Hardy, C. M. , Bell, J. R. , Strauss, J. H. , and Marshall, I. D. (1984). Virology 133, 416-426] and has been classified as the sole known member of a seventh alphavirus serocomplex. The complete nucleotide sequence of BFV genomic RNA is 11,488 nucleotides in length excluding the poly(A) tail. Two long open reading frames in the RNA encode a nonstructural polyprotein of 2411 amino acids and a structural polyprotein of 1239 amino acids, respectively. The BFV envelope protein E2 is unique among sequenced alphaviruses in having no N-linked glycosylation sites; E1 carries two glycosylation sites. From amino acid sequence comparisons with sequenced alphaviruses BFV is most closely related to Ross River and Semliki Forest viruses. Sequence homology between BFV and other alphaviruses is relatively uniform along the length of the nonstructural and structural polyproteins, providing no evidence that BFV has arisen from recombination between ancestral alphaviruses in the coding region of the genome. The BFV 3' noncoding region of 445 nucleotides has unusual features. There are two unrelated sequence blocks of 48 nucleotides (sequence I) and 47 nucleotides (sequence II) both of which are repeated once. Sequence I is closely related to a repeat in the 3' noncoding region of Ross River and Getah viruses; sequence II is unrelated to repeat blocks in other sequenced alphaviruses. Thus, recombination between ancestral viruses may have played a role in the evolution of the BFV 3' noncoding region.