Miracle-dz/UniFAR-FTUs huggingface dataset:
Incorporation of Solvent Effect into Multi-Objective Evolutionary Algorithm for Improved Protein Structure Prediction

The problem of predicting the three-dimensional (3-D) structure of a protein from its one-dimensional sequence has been called the “holy grail of molecular biology”, and it has become an important part of structural genomics projects. Despite the rapid developments in computer technology and computational intelligence, it remains challenging and fascinating. In this paper, to solve it we propose a multi-objective evolutionary algorithm. We decompose the protein energy function Chemistry at HARvard Macromolecular Mechanics force fields into bond and non-bond energies as the first and second objectives. Considering the effect of solvent, we innovatively adopt a solvent-accessible surface area as the third objective. We use 66 benchmark proteins to verify the proposed method and obtain better or competitive results in comparison with the existing methods. The results suggest the necessity to incorporate the effect of solvent into a multi-objective evolutionary algorithm to improve protein structure prediction in terms of accuracy and efficiency.
Ingaasp/ingaasp multiple-quantum-well modulator with improved saturation intensity and bandwidth over 20 ghz

A single-mode modulator was realized from an AP-MOCVD grown structure. The multiple-quantum-well electroabsorptive material is made of shallow InGaAsP wells separated by InGaAsP barriers. It exhibits at 1.54 mu m (TE) a 17 dB extinction ratio for a 3 V drive voltage, a 2.7 dB on-state loss and a small-signal bandwidth over 20 GHz with 1-2 mW of coupled optical power. <<ETX>>
The Effects of Cognitive Style, Shopping Experience and Consumer Demographics on Consumer Reactions to Quantity Surcharges

ABSTRACT Quantity surcharges occur when large quantities of a product are sold at a higher unit price compared to smaller quantities. As such, quantity surcharges violate consumer beliefs that one should receive a discount for having purchased larger amounts of a product. Much of the existing research in this area has focused on the incidence of quantity surcharges, and less focus has been given to consumer reactions to quantity surcharge offers. Utilizing a national survey of 318 consumers, this paper explores the effects of quantity surcharges on consumer perceptions of sellers, and examines how these perceptions are affected by consumers' cognitive style, shopping experience and demographics.
Determining bonus in Enterprise Resource Planning at Human Resource Management module using Key Performance Indicator

Bonus is a reward from company for an employee who gave the best work to the company. Reward is important to get the employee's loyalty. Basically employee want to be appreciate what they do and Company want employee's loyalty. There must be ‘win win’ solution between them. Then this paper explain how to determine bonus in Enterprise Resource Planning at Human Resource Management module based Key Performance Indicator on. There are several ways to determine bonus. the bonus is determined by how long the employee has worked at the company. It makes some disadvantages for the company, it caused no efficient human resource. The company has to give them a bonus based on years of service, not experience and skill. There is no guarantee if an employee has more years of service, then more profit the company gained. Furthermore, it can impact customer loyalty.
Essays on derivatives and risk management on freight and commodity : an attempt to anticipate and hedge the market volatilities

This thesis investigates three unexplored areas in maritime freight and commodity markets; 1) the relationship between commodity and freight markets; 2) the interaction of freight options market with the freight futures and underlying freight rate markets; 3) improving the hedging performance of freight futures contracts by cross hedge technique. Details provided as follows: Firstly, information flows between commodity and shipping freight markets are essential for the participants of the international shipping industry for optimising ship chartering strategies, investment positioning and risk management. This study investigates the economic relationships between commodities corresponding shipping freight rate markets, along with both their futures contracts, through a comprehensive dataset of 65 variables analysed simultaneously through a dynamic factor model. In contrast, previous literature has only investigated the bi-variate framework which limits some of the crossmarket information. Commodity markets (especially the crude oil and other oil derivative products) lead the freight rates driving price movements. Secondly, the study fills the gap by investigating the economic spillovers of both returns and volatilities between time-charter rates, freight futures, and the un-investigated freight options in the international dry-bulk shipping industry. Empirical results indicate the existence of significant information transmission in both returns and volatilities between the three related markets, which we attribute to varying trading activity and market liquidity. The results also point out that, consistent with theory, the freight futures market informationally leads the freight rate market, though surprisingly, freight options lag both futures and physical freight rates. Lastly, the international shipping freight rates are susceptible to high market volatilities demanding diversifying and hedging the associated risks. This study develops a portfolio-based methodological framework aiming to improve freight rate risk management to create market stability. The study also offers, for the first time, evidence of the hedging performance of the recently developed container freight futures market. The approach utilises portfolios of the container, dry bulk and tanker freight futures along with corresponding portfolios of physical freight rates to improve the efficacy of risk diversification for shipping market practitioners. The results of this thesis provide not only commercial and financial risk management solutions but also offer valuable insights for economic development policymakers and regulators. The empirical findings uncover necessary implications for overall business, commercial, and hedging strategies in the shipping industry, while they can ultimately lead to a more liquid and efficient freight futures market.
Fault-tolerant topology control for heterogeneous wireless sensor networks using Multi-Routing Tree

Fault-tolerant topology control is a critical problem in WSNs. It is important for improving network lifetime and reliability. In this paper, we present a novel algorithm FTMRT, which ensures Fault Tolerance by constructing a Multi-Routing Tree. We firstly construct a multi-routing tree of the initial topology, which ensures there are at least k-disjoint paths from each sensor to the set of supernodes. And then each sensor adjusts its transmission power according to the multi-routing tree to form the fault-tolerant network topology. In the topology maintenance phase, topology reconstruction is invoked each time there are some node fail and the supernode connectivity is broken. The effectiveness of the proposed algorithm is validated through simulation experiments.
p38 Mitogen-Activated Protein Kinase Can Be Involved in Transforming Growth Factor β Superfamily Signal Transduction in Drosophila Wing Morphogenesis

ABSTRACT p38 mitogen-activated protein kinase (p38) has been extensively studied as a stress-responsive kinase, but its role in development remains unknown. The fruit fly, Drosophila melanogaster, has two p38 genes, D-p38a and D-p38b. To elucidate the developmental function of the Drosophilap38’s, we used various genetic and pharmacological manipulations to interfere with their functions: expression of a dominant-negative form of D-p38b, expression of antisense D-p38b RNA, reduction of theD-p38 gene dosage, and treatment with the p38 inhibitor SB203580. Expression of a dominant-negative D-p38b in the wing imaginal disc caused a decapentaplegic (dpp)-like phenotype and enhanced the phenotype of a dpp mutant. Dpp is a secretory ligand belonging to the transforming growth factor β superfamily which triggers various morphogenetic processes through interaction with the receptor Thick veins (Tkv). Inhibition of D-p38b function also caused the suppression of the wing phenotype induced by constitutively active Tkv (TkvCA). Mosaic analysis revealed that D-p38b regulates the Tkv-dependent transcription of theoptomotor-blind (omb) gene in non-Dpp-producing cells, indicating that the site of D-p38b action is downstream of Tkv. Furthermore, forced expression of TkvCA induced an increase in the phosphorylated active form(s) of D-p38(s). These results demonstrate that p38, in addition to its role as a transducer of emergency stress signaling, may function to modulate Dpp signaling.
DECISION TO PURCHASE ONLINE AIRLINE TICKETS OF HO CHI MINH CITY CUSTOMERS

Abstract. The study aimed to identify and measure the factors affecting the decision to purchase online airline tickets in Ho Chi Minh City, Vietnam (HCMC) by surveying 536 customers aged 18 and over who bought airline tickets online and live in Ho Chi Minh City. The SPSS 20 tool was used to analyze the reliability of the scale through the Cronbach's Alpha coefficient, EFA exploratory factor analysis, AMOS 22 software to calibrate the scale by CFA confirmatory factor analysis, and evaluated by linear SEM analysis. Research results show that positive impact factors, decreasing by their strength, include: Perceived benefit, Perceived ease of use, Reputation of the airline, Subjective norm, Reliability. Meanwhile, Risk perception has a negative impact on the intention to buy airline tickets of customers. Research also indicates that the intention to purchase airline tickets online has an impact on purchase decisions. The results also help managers recognize the importance of the factors that affect the buying behavior of the consumers, and consequently make appropriate strategic adjustments and actions in the competitive process for online airline tickets presently. Keywords: online airline ticket, HCMC consumers, purchase intention, purchase decision
Current Concepts Review: Peroneal Tendon Subluxation and Dislocation

Peroneal tendon subluxation or dislocation often is misdiagnosed as an ankle sprain.1,15,18,33 Chronic dislocation can cause chronic pain or a sense of instability. Although both conservative and operative methods have been advocated for treatment of acute injuries, currently surgical management is generally recommended for both acute and chronic injuries. Numerous operative techniques have been described, including rerouting procedures, soft-tissue repair and reconstruction, and bony procedures. Results usually are excellent after correct diagnosis and appropriate treatment.4
The geometry of taking flight: Limb morphometrics in Mesozoic theropods

Theropoda was one of the most successful dinosaurian clades during the Mesozoic and has remained a dominant component of faunas throughout the Cenozoic, with nearly 10,000 extant representatives. The discovery of Archaeopteryx provides evidence that avian theropods evolved at least 155 million years ago and that more than half of the tenure of avian theropods on Earth was during the Mesozoic. Considering the major changes in niche occupation for theropods resulting from the evolution of arboreal and flight capabilities, we have analyzed forelimb and hindlimb proportions among nonmaniraptoriform theropods, nonavian maniraptoriforms, and basal avialans using reduced major axis regressions, principal components analysis, canonical variates analysis, and discriminant function analysis. Our study is the first analysis on theropod limb proportions to apply phylogenetic independent contrasts and size corrections to the data to ensure that all the data are statistically independent and amenable to statistical analyses. The three ordination analyses we performed did not show any significant groupings or deviations between nonavian theropods and Mesozoic avian forms when including all limb elements. However, the bivariate regression analyses did show some significant trends between individual elements that suggested evolutionary trends of increased forelimb length relative to hindlimb length from nonmaniraptoriform theropods to nonavian maniraptoriforms to basal avialans. The increase in disparity and divergence away from the nonavian theropod body plan is well documented within Cenozoic forms. The lack of significant groupings among Mesozoic forms when examining the entire theropod body plan concurrently suggests that nonavian theropods and avian theropods did not substantially diverge in limb proportions until the Cenozoic. J. Morphol. 276:152–166, 2015. © 2014 Wiley Periodicals, Inc.
Comparison of Maitland Thoracic Spine Manipulation Versus Maitland Cervical Spine Mobilization in Chronic Unilateral C6 â€“ C7 Cervical Radiculopathy

Background:Â Â Radicular pains are very common in cervical region due to C 6 â€“ C 7 nerve root involvement which results discomfort and restriction of mobility of upper and lower segments of cervical and thoracic spine. A lot of evidences about non-operative treatments have been derived for managing cervical radiculopathies with a little documentation of manual the rapy. So, in this study, Maitland concept of manipulation and mobilization at two different regions of spine (thoracic and cervical) respectively, was used to see the change in pain reduction and restoration of normal functional abilities. Methodology:Â Â A study design of Comparative single blinded, randomized control clinical trials was used. 100 patients having chronic unilateral C 6 â€“ C 7 cervical radiculopathyâ€™s symptoms due to disc prolapsed, divided into two groups with simple random sampling as guided per-consolidated standards of reporting trials (CONSORT) guidelines were used. First group was managed with Maitland thoracic spine manipulation (MTSM), mechanical intermittent cervical traction (MICT) for 10 minutes and regime of strengthening exercises (SE) and second group was managed with Maitland cervical spine mobilization (MCSM), MICT and SE. The duration of treatment was four weeks at the rate of three times in one week. Two outcome measures numeric pain rating scale (NPRS) and Neck disability index (NDI) questionnaire were used for evaluation and investigation. Data was collected at start, after two and after four Weeksâ€™s treatment. Independent T test with extension of Leveneâ€™s test was used with 0.05% level of confidence. Results:Â Â The calculated p value for NPRS and NDI for group A (MTSM) was P = 0.000which was less than 0.05 having validation of significant changes. So, we reject our Null hypothesis that MTSM is more effective than MCSM. Conclusion:Â Â The result shows that MTSM and MC-SM were effective techniques for pain reduction and functional abilities restoration. However, the subjects of first group with MTSM, MICT and SE presented better progress in reduction of neck ache and refining functional status during comparison.
An Approach of Adaptive Fuzzy Modeling and Application to Inverted Pendulum Control

An approach of adaptive fuzzy modeling based parameter optimization fuzzy tree for a class of nonlinear time-invariant systems is proposed, fuzzy state equation model based on the adaptive fuzzy tree algorithm is created, which is used to partition the workspace of nonlinear system adaptively. The model obtained by this new method is more accuracy and lower computational cost. The new method is applied to model and control the inverted pendulum system; the numerical simulation shows that the method is effective
L'approche PST comme outil de rationalisation de la démarche de conception innovante

Le sujet traite concerne le processus d'innovation, si important aujourd'hui pour la competitivite des entreprises. Apres une relecture des travaux de la litterature sur la conception pour innover, les travaux de these se centrent precisement sur les prises methodologiques du processus de conception en innovation. D'abord, apres une precision sur la definition du livrable de ce processus, nommee innovation potentielle, sont identifies deux indicateurs de resultat relatifs au potentiel de nouvelle proposition de valeur et a la faisabilite technologique ainsi que l'interet majeur de considerer un raisonnement de conception exploratoire. Pour pouvoir initier ce dernier, par l'enonce d'une nouvelle intention, le modele "multi-entrees" PST propose au travers des trois dimensions, Potentiel (P) - Systeme (S) - Techno (T), de nombreux angles d'attaque possibles. Ensuite, la these s'attache a preciser plus particulierement le raisonnement de conception exploratoire en le presentant comme un jeu de questions "logique" au travers la aussi des trois dimensions P, S et T (modele "multi-questions" PST). Le role majeur de l'activite de modelisation dans ce type de raisonnement (PST) et plus globalement en innovation est alors mis en exergue. Enfin, il est montre comment exploiter et affiner les resultats d'un raisonnement PST pour obtenir un livrable de conception satisfaisant au mieux les indicateurs de resultat identifies, d'abord en utilisant des outils de comparaison permettant de preciser la definition de l'objet a concevoir tant en termes d'objectifs a satisfaire que de caracteristiques de solution, et ensuite en presentant differentes voies amenant a ameliorer la nouvelle proposition de valeur du produit, afin que l'innovation potentielle devienne reelle. Les travaux se concluent sur leur apport (prises methodologiques) dans la pratique de la conception pour innover et sur des perspectives portant sur l'interet d'un outil logiciel et sur la forme de l'organisation supportant le processus propose.
Cross-Cultural and Psychometric Properties Assessment of the Exercise Self-Efficacy Scale in Individuals with Spinal Cord Injury.

INTRODUCTION The Exercise Self-Efficacy scale (ESES) is a reliable measure, in the English language, of exercise self-efficacy in individuals with spinal cord injury. The aim of this study was to culturally adjust and validate the Exercise Self-Efficacy scale in the Portuguese language. MATERIAL AND METHODS The Exercise Self-Efficacy scale was applied to 76 subjects, with three-month intervals (three applications in total). The reliability was appraised using the intra-class correlation coefficient and Bland-Altman methods, and the internal consistency was evaluated using Cronbach´s alpha. The Exercise Self-Efficacy scale was correlated with the domains of the Quality of life Questionnaire SF-36 and Functional Independence Measure and tested using the Spearman rho coefficient. RESULTS The Exercise Self-Efficacy scale-Brazil presented good internal consistency (alpha 1 = 0.856; alpha 2 = 0.855; alpha 3 = 0.822) and high reliability in the test-retest (intra-class correlation coefficient = 0.97). There was a strong correlation between the Exercise Self-Efficacy scale-Brazil and the SF-36 only in the functional capacity domain (rho = 0.708). There were no changes in Exercise Self-Efficacy scale-Brazil scores between the three applications (p = 0.796). DISCUSSION The validation of the Exercise Self-Efficacy scale questionnaire permits the assessor to use it reliably in Portuguese speaking countries, since it is the first instrument measuring self-efficacy specifically during exercises in individuals with spinal cord injury. Furthermore, the questionnaire can be used as an instrument to verify the effectiveness of interventions that use exercise as an outcome. CONCLUSION The results of the Brazilian version of the Exercise Self-Efficacy scale support its use as a reliable and valid measurement of exercise self-efficacy for this population.
Infragravity waves and bore merging

The phenomenon of bore merging is investigated using two high-resolution laboratory experiments including bichromatic and irregular wave conditions. The locations at which waves start merging are identified and the hydrodynamic conditions in the vicinity of the merging points are examined. Bore merging takes place in the inner surf zone for all conditions considered. The infragravity- to short-wave height ratio is close to or larger than one at the merging point, indicating that bore merging occurs in a part of the surf zone that is already dominated by the infragravity waves. Our data analysis is supplemented by numerical simulations that confirms the importance of infragravity waves in the occurrence bore merging. Moreover, our simulations suggest that bore merging has a very limited effect on the infragravity wave field. This casts doubts on the importance of bore merging as an infragravity wave generation mechanism.
Detection and Mapping of Latent Fingerprints by Laser-Induced Breakdown Spectroscopy

Detection of latent fingerprints on a Si wafer by laser-induced breakdown spectroscopy (LIBS) is demonstrated using approximately 120 fs pulses at 400 nm with energies of 84 ± 7 μJ. The presence of a fingerprint ridge is found by observing the Na emission lines from the transferred skin oil. The presence of the thin layer of transferred oil was also found to be sufficient to suppress the LIBS signal from the Si substrate, giving an alternative method of mapping the latent fingerprint using the Si emission. A two-dimensional image of a latent fingerprint can be successfully collected using these techniques.
Disrupted lives and threats to identity: The experiences of people with colorectal cancer within the first year following diagnosis

In this article we focus on the experiences of 18 people with colorectal cancer, involved in a large longitudinal qualitative study to explore people’s experiences of cancer within the first year following diagnosis. Three depth interviews over the course of the year were carried out. During analysis, we drew on biographically informed approaches of understanding chronic illness, particularly the work of Bury and Charmaz, to explore the extent to which people within the first year following diagnosis experience cancer as biographically disruptive. We explore the biographical work that individuals carry out in the context of an assault on their identity and discuss the relevance of the concept biographical disruption for people who experience cancer as an acute, chronic and/or life-threatening condition. We also discuss the concept’s relevance for people who have lived a hard life and, hence, may anticipate these types of disruptions in their lives and experience their impact differently. We conclude that universal application of the concept biographical disruption to the experience of cancer within the first year of diagnosis is not appropriate. This study has implications for cancer services, in particular, the findings call for the development of interventions to support those people who experience cancer as an assault on their identity.