Miracle-dz/UniFAR-FTUs huggingface dataset:
Potential Role of Neuroimaging Markers for Early Diagnosis of Dementia in Primary Care.

BACKGROUND The use of imaging markers for the diagnosis of predementia and early dementia stages of Alzheimer's disease (AD) has widely been explored in research settings and specialized care. The use of these markers in primary care has yet to be established. OBJECTIVE Summarize current evidence for the usefulness of imaging markers for AD in primary compared to specialized care settings. METHOD Selective overview of the literature, and pilot data on the use of MRI-based hippocampus and basal forebrain volumetry for the discrimination of AD dementia and mild cognitive impairment (MCI) cases from healthy controls in 58 cases from a primary care cohort and 58 matched cases from a memory clinic's sample. RESULTS Molecular imaging marker of amyloid pathology, and volumetric markers of regional and whole brain atrophy support the diagnosis of AD dementia and MCI due to AD, and contribute to confidence in the differential diagnosis of AD and non-AD related dementias in specialized care. Limited evidence from the literature and our primary care cohort suggests that the diagnostic accuracy of volumetric imaging markers may be similar in the dementia stage of AD, but may be inferior for cases with MCI in primary compared with specialized care. CONCLUSION Evidence is still widely lacking on the use of imaging markers for early and differential diagnosis of AD dementia, and detection of prodromal AD in primary care. Further progress to fill this gap will depend on the availability of international multimodal data from well-defined primary care cohorts.
Identification of complex relationship between protein kinases and substrates during the cell cycle of HeLa cells by phosphoproteomic analysis

Each phase of eukaryotic cell cycle is tightly controlled by multicomponent regulatory networks based on complex relationships of protein phosphorylation. In order to better understand the relationships between kinases and their substrate proteins during the progression of cell cycle, we analyzed phosphoproteome of HeLa cells during G1, S, and G2/M phases of cell cycle using our developed quantitative phosphoproteomic approaches. A total of 4776 high‐confidence phosphorylation sites (phosphosites) in 1177 proteins were identified. Bioinformatics analysis for predicting kinase groups revealed that 46 kinase groups could be assigned to 4321 phosphosites. The majority of phosphoproteins harboring two or more phosphosites could be phosphorylated by different kinase groups, in which nine major kinase groups accounted for more than 90% phosphosites. Further analyses showed that approximately half of the examined two phosphosite combinations were correlatively regulated, regardless of whether the kinase groups were same or not. In general, the majority of proteins containing correlated phosphosites had solely co‐regulated or counter‐regulated phosphosites, and co‐regulation was significantly more frequent than counter‐regulation, suggesting that the former may be more important for regulating the cell cycle. In conclusion, our findings provide new insights into the complex regulatory mechanisms of protein phosphorylation networks during eukaryotic cell cycle.
Prone-position ventilation induces sustained improvement in oxygenation in patients with acute respiratory distress syndrome who have a large shunt*

Objectives Prone-position ventilation (PPV) induces acute improvement in oxygenation in many patients with acute respiratory distress syndrome (ARDS), with some maintaining their oxygenation even after they were returned to the supine position, but it is unclear what clinical factors determine the sustained oxygenation benefit. We hypothesized that patients with ARDS who have a larger shunt would have a better acute and sustained oxygenation response to PPV. Design Prospective, nonrandomized interventional study. Setting Medical and surgical intensive care units, university tertiary care center. Patients Twenty-two consecutive patients, with ARDS with an average Pao2/Fio2 of 94, were administered PPV for 12 hrs followed by supine-position ventilation for 2 hrs. Measurements Hemodynamic and gas exchange variables were monitored. The shunt was measured as venous admixture at an Fio2 of 1.0, and compliances of the respiratory system, lung, and chest wall were measured by the esophageal balloon technique before PPV, during PPV, and during subsequent supine-position ventilation. Main Results Fourteen patients (64%) responded to PPV, with Pao2/Fio2 increasing by ≥20. These changes were associated with a decrease in chest wall compliance. Responders had significantly shorter time from ARDS to PPV, a lower baseline Pao2/Fio2, and a higher venous admixture. All responders maintained the improvement in oxygenation and had a greater respiratory system compliance after returning to the supine position. Time from ARDS to PPV and baseline lung injury score were negatively associated, whereas chest wall compliance, heart rate, and Paco2 were positively associated with sustained improvement in oxygenation. Conclusions PPV induced acute and sustained improvement in oxygenation in many patients with ARDS. The sustained improvement is more significant if PPV is administered early to patients with a larger shunt and a more compliant chest wall. Measuring venous admixture and chest wall compliance before PPV may help select a subgroup of patients with ARDS who may benefit the most from PPV.
Self-reported versus informant-reported depressive symptoms in adults with mild intellectual disability.

BACKGROUND Virtually nothing is known about potential differences in the types of depression symptoms reported by adults with mild intellectual disability (ID) on self-reported questionnaires as compared with the types of symptoms reported by caregivers on informant questionnaires. Moreover, little is known about how the presentation of depression among adults with mild ID varies based on socio-demographic characteristics. METHODS We compared findings from two self-reported questionnaires, the Self-Reported Depression Questionnaire (SRDQ) and the Glasgow Depression Scale for People with a Learning Disability (GDS), to that of an informant questionnaire of depressive symptoms, the Glasgow Depression Scale--Caregiver Supplement (CGDS), in 80 adults with mild ID. We also examined the association between age, sex, IQ and the presence of a co-occurring psychiatric disorder and frequency of affective, cognitive and somatic depressive symptoms in our sample of adults with mild ID. RESULTS Adults with mild ID self-reported a higher frequency of affective and cognitive depressive symptoms than staff reported on the informant measure. Staff reported a higher frequency of somatic symptoms than adults with mild ID on one of the self-reported questionnaires (GDS) and a similar frequency on the other self-reported questionnaire (SRDQ). Important differences were found in the types of depressive symptoms based on their IQ, age and presence of a co-occurring psychiatric disorder. CONCLUSION Informant questionnaires offer valuable information, but assessment should include self-reported questionnaires as these questionnaires add unique information about internalised experiences (affective and cognitive symptoms) of adults with mild ID that may not be apparent to caregivers. Health care providers should be made aware of the important differences in the presentation of depressive based on their IQ, age and presence of a co-occurring psychiatric disorder.
Regulation of gamma-aminobutyric acid synthesis in the brain.

gamma-Aminobutyric acid (GABA) is synthesized in brain in at least two compartments, commonly called the transmitter and metabolic compartments, and because regulatory processes must serve the physiologic function of each compartment, the regulation of GABA synthesis presents a complex problem. Brain contains at least two molecular forms of glutamate decarboxylase (GAD), the principal synthetic enzyme for GABA. Two forms, termed GAD65 and GAD67, are the products of two genes and differ in sequence, molecular weight, interaction with the cofactor, pyridoxal 5'-phosphate (pyridoxal-P), and level of expression among brain regions. GAD65 appears to be localized in nerve terminals to a greater degree than GAD67, which appears to be more uniformly distributed throughout the cell. The interaction of GAD with pyridoxal-P is a major factor in the short-term regulation of GAD activity. At least 50% of GAD is present in brain as apoenzyme (GAD without bound cofactor; apoGAD), which serves as a reservoir of inactive GAD that can be drawn on when additional GABA synthesis is needed. A substantial majority of apoGAD in brain is accounted for by GAD65, but GAD67 also contributes to the pool of apoGAD. The apparent localization of GAD65 in nerve terminals and the large reserve of apoGAD65 suggest that GAD65 is specialized to respond to short-term changes in demand for transmitter GABA. (ABSTRACT TRUNCATED AT 250 WORDS)
Is France converging or not? The role of industrial relations

The European Union (EU) exhibits substantial heterogeneity across the member states in terms of employment and social outcomes, as well as labour market and social protection institutions. This heterogeneity has been analysed in the literature about social protection regimes (Esping-Andersen 1990) and varieties of capitalism (Amable 2003). Institutional and policy diversity in the fields of employment and social protection is recognised by the EU in accordance with the subsidiary principle, although some common rules and goals have been adopted progressively throughout the construction of social Europe. In such a context social convergence in Europe remains a challenge, especially within the framework of low growth and persistent unemployment in many countries. Several issues arise in relation to social convergence. First, analysing convergence requires a set of common indicators, which was recently renewed within the framework of the European Pillar of Social Rights (EPSR) adopted in November 2017. However, this set of indicators does not cover all the dimensions of social convergence and needs to be supplemented. Second, policy reforms have been numerous in Europe over the past ten years, and their consequences for social convergence are difficult to evaluate. Third, the role of industrial relations in these dynamics should not be underestimated: social dialogue and collective bargaining at different levels play an important role in the determination of wages and working and employment conditions (working time and types of contract), and may influence labour market inequalities (by gender, age and education level). In this chapter we address these issues for the French case. After putting the EPSR in the context of EU social and employment policies, we construct a framework that enables us to identify France’s particular features with regard to a large set of convergence indicators (based on an extension of the EPSR and consistent with the enlarged perspective developed in this book). We then examine the contribution of policy reforms and new trends in industrial relations to four specific policy areas, characterised by some convergence but with persistent gaps (employment of older workers, gender equality and labour market flexibilisation) or by continuing peculiarity (wage determination). The case study provides a specific focus on lifelong learning policies, which includes a comparative perspective on the heterogeneous national regimes in the EU, as well as an analysis of recent policy and institutional trends in France. Regarding industrial relations, it is important to stress that France is in the course of implementing important reforms, which have been accelerated over the past two years
Gender Dimensions of (Non)Violence in Communal Conflict: The Case of Jos, Nigeria

Peacebuilding is more likely to succeed in countries with higher levels of gender equality, but few studies have examined the link between subnational gender relations and local peace and, more generally, peacebuilding after communal conflict. This article addresses this gap. I examine gender relations and (non)violence in ethno-religious conflict in the city of Jos in central Nigeria. Jos and its rural surroundings have repeatedly suffered communal clashes that have killed thousands, sometimes within only days. Drawing on qualitative data collected during fieldwork, I analyze the gender dimensions of violence, nonviolence, and postviolence prevention. I argue that civilian agency is gendered. Gender relations and distinct notions of masculinity can facilitate or constrain people’s mobilization for fighting. Hence, a nuanced understanding of the gender dimensions of (non)violence has important implications for conflict prevention and local peacebuilding.
κ-Same-Net: Neural-Network-Based Face Deidentification

An increasing amount of video and image data is being shared between government entities and other relevant stakeholders and requires careful handling of personal information. A popular approach for privacy protection in such data is the use of deidentification techniques, which aim at concealing the identity of individuals in the imagery while still preserving certain aspects of the data deidentification. In this work, we propose a novel approach towards face deidentification, called κ-Same-Net, which combines recent generative neural networks (GNNs) with the well-known κ-anonymity mechanism and provides formal guarantees regarding privacy protection on a closed set of identities. Our GNN is able to generate synthetic surrogate face images for idedentification by seamlessly combining features of identities used to train the GNN mode. furthermore, it allows us to guide the image-generation process with a small set of appearance-related parameters that can be used to alter specific aspects (e.g., facial expressions, age, gender) of the synthesized surrogate images. We demonstrate the feasibility of κ-Same-Net in comparative experiments with competing techniques on the XM2VTS dataset and discuss the main characteristics of our approach.
Feature selection based on fuzzy extension matrix for multi-class problem

Feature subset selection is one of the widely used and practical methods for pattern recognition and classification, which aims to reduce the number of features to be used. Optimal fuzzy-valued feature subset selection (OFFSS) method is efficient for feature subset selection of two-class problem. However, the original OFFSS is not suitable for multi-class problem. This paper gives an improved version of OFFSS. The OFFSS algorithm is extended to the multi-class problem in which information entropy is used to reduce computational complexity of the method. The feasibility and simplicity of the improved algorithm are demonstrated by applying it to fuzzy decision tree induction.
Comparison of Insall-Salvati ratios in children with an acute anterior cruciate ligament tear and a matched control population.

OBJECTIVE An anterior cruciate ligament (ACL) injury is an increasingly recognized cause of knee pain in young patients and in athletes in particular and can be detected non-invasively with MRI. Anecdotal information suggests that patella alta may be more common in the setting of this injury, but no study has documented this phenomenon. This study sought to test whether an ACL tear is associated with an increased Insall-Salvati ratio suggestive of patella alta. MATERIALS AND METHODS Measurements of patellar height, patellar tendon length, and the Insall-Salvati ratio obtained from MRI of the knee were compared for 34 children with an arthroscopically proven ACL tear (mean age ± SD, 12.4 ± 1.4 years) and 36 control subjects with normal knee examinations (12.8 ± 2.1 years); these measurements were performed independently by two observers. RESULTS Patellar tendon length (47.6 ± 6.6 mm vs 40.4 ± 5.7 mm) and patellar position calculated as the Insall-Salvati ratio (1.16 ± 0.16 vs 0.99 ± 0.14) were significantly greater in the knees with an ACL injury than in those without an internal injury, respectively, on MRI (p < 0.001). Patella length was not significantly different between the two groups (patients vs control subjects, 41.1 ± 4.2 mm vs 40.6 ± 2.7 mm, respectively; p = 0.523). There was good to excellent interobserver and intraobserver correlation for all measurements. CONCLUSION There is a significant association between an ACL tear and increased patellar tendon length with a greater Insall-Salvati ratio. The mechanism for this finding is unclear, but this association provides support to suggest relative patella alta may be a risk factor for ACL injuries in pediatric patients.
Validity and reliability of measurements obtained with an "activity monitor" in people with and without a transtibial amputation.

BACKGROUND AND PURPOSE In this study, the validity and reliability of measurements obtained with an "Activity Monitor" (AM) were examined. The instrument is designed to monitor ambulatory activity by use of accelerometer signals, and it detects several activities associated with mobility (standing, sitting, lying, transitions, movement-related activities). SUBJECTS Four men with a transtibial amputation and 4 men without a transtibial amputation participated. METHODS The subjects performed normal daily activities, during which accelerations were measured and videotape recording were made (reference method). Validity was assessed by calculating agreement scores between the AM output and the videotape recordings and by comparing the number of transitions and the duration of activities determined by both methods. RESULTS The overall agreement between the AM output and the videotape recordings was 90%. Other agreement scores, in addition to the determination of the number of transitions and the duration of activities, were generally within a range of error of 0% to 10%. CONCLUSION AND DISCUSSION The reliability and validity of the AM measurements appeared to be good, which supports its potential use in rehabilitation and physical therapy. [Bussmann HBJ, Reuvekamp PJ, Veltink PH, et al. Validity and reliability of measurements obtained with an "Activity Monitor" in people with and without a transtibial amputation.
Research on Two-Way Logistics Operation with Uncertain Recycling Quality in Government Multi-Policy Environment

With the emphasis on environmental protection issues, countries have introduced a number of circular economy-related policies aimed at guiding enterprises to green development and green innovation. At the same time, they are encouraged to strengthen the combination of forward logistics and reverse logistics, providing an effective way to improve resource shortages and reduce environmental pollution. However, the quality of recycled products in reverse logistics is often uncertain, which not only increases the risk of production decisions of remanufacturers, but also affects the sales of new products in the forward logistics to a certain extent. Based on the uncertainty of recycling quality of waste products and the controllability of remanufacturing technology level, this paper studies the impact of various regulatory environments on the operation of a two-way logistics system. We solve the decision model of the system through game theory. The results show that the government’s policy can improve product recycling quality and remanufacturing technology. However, recycling rewards and punishments, remanufacturing technology subsidies, and recycling payment factors need to be within a certain range to ensure the effectiveness of the trading market. When the recycling regulation has been implemented, it is beneficial for manufacturers to choose to improve their remanufacturing technology level. This means that the combined effect of multiple policies is more conducive to the operation of a two-way logistics system.
High Penetrance of a Pan-Canina Type rDNA Family in Intersection Rosa Hybrids Suggests Strong Selection of Bivalent Chromosomes in the Section Caninae

All dogroses (Rosa sect. Caninae) are characterized by the peculiar canina meiosis in which genetic material is unevenly distributed between female and male gametes. The pan-canina rDNA family (termed beta) appears to be conserved in all dogroses analyzed so far. Here, we have studied rDNAs in experimental hybrids obtained from open pollination of F1 plants derived from 2 independent intersectional crosses between the pentaploid dogrose species (2n = 5x = 35) Rosa rubiginosa as female parent (producing 4x egg cells due to the unique asymmetrical canina meiosis) and the tetraploid (2n = 4x = 28) garden rose R. hybrida ‘André Brichet' as male parent (producing 2x pollen after normal meiosis). We analyzed the structure of rDNA units by molecular methods [CAPS and extensive sequencing of internal transcribed spacers (ITS)] and determined the number of loci on chromosomes by FISH. FISH showed that R. rubiginosa and ‘André Brichet' harbored 5 and 4 highly heteromorphic rDNA loci, respectively. In the second generation of hybrid lines, we observed a reduced number of loci (4 and 5 instead of the expected 6). In R. rubiginosa and ‘André Brichet', 2-3 major ITS types were found which is consistent with a weak homogenization pressure maintaining high diversity of ITS types in this genus. In contrast to expectation (the null hypothesis of Mendelian inheritance of ITS families), we observed reduced ITS diversity in some individuals of the second generation which might derive from self-fertilization or from a backcross to R. rubiginosa. In these individuals, the pan-canina beta family appeared to be markedly enriched, while the paternal families were lost or diminished in copies. Although the mechanism of biased meiotic transmission of certain rDNA types is currently unknown, we speculate that the bivalent-forming chromosomes carrying the beta rDNA family exhibit extraordinary pairing efficiency and/or are subjected to strong selection in Caninae polyploids.