Miracle-dz/UniFAR-FTUs huggingface dataset:
On the tip of the brain: Understanding when negative reputational events can have positive reputation spillovers, and for how long

Correspondence Srikanth Paruchuri, Management & Organizations Department, Smeal College of Business, The Pennsylvania State University, University Park, PA 16802. Email: sup28@psu.edu Abstract Research Summary: This study contributes to the reputation spillover literature by showing how a crisis caused by a firm's capability failure enhances the reputations of its rivals. We consider how the combination of rivals' characteristics that increase their associability with the focal firm and the extent to which the crisis is salient in the minds of stakeholders can lead to positive reputation spillovers, and we also explore how long the positive reputation spillover lasts. Using a natural experiment based on the Escherichia coli outbreak in Chipotle's Seattle restaurants, we find that the reputations of other restaurants in the Seattle region were enhanced when the E. coli breakout was more salient and thus cognitively available, but only for Mexican restaurants that were geographically proximal to a Chipotle. Managerial Summary: In this study we conducted a natural experiment based on Chipotle's 2015 E. coli breakout to explore how a firm's capability failure affects the reputation of its competitors. We found that failures due to firm practices that differentiate the firm from others in its industry result in positive reputation spillovers, but only for the firms that are the most similar, and only for as long as the failure is salient to stakeholders. Thus, the benefit to firms from a competitor's failure is only temporary, and will not be experienced equally.
Consciousness Reconsidered

Every word to utter from the writer involves the element of this life. The writer really shows how the simple words can maximize how the impression of this book is uttered directly for the readers. Even you have known about the content of consciousness reconsidered so much, you can easily do it for your better connection. In delivering the presence of the book concept, you can find out the boo site here.
Calcium Transients Modulate Action Potential Repolarizations in Ventricular Fibrillation

Action potential alternans has been an indicator of ischemic disease and vulnerability to ventricular fibrillation (VF). The mechanisms of alternans are linked to the anomalies in intracellular Ca <sup>2+</sup> (Ca<sub>i</sub>) handling by either spontaneous Ca<sup>2+ </sup> release or modulation of action potential duration (APD), which may promote wave breaks in VF. We investigated possible role of Ca<sup>2+</sup> in wave breaks by simultaneously measuring transmembrane potential (V<sub>m</sub>) and intracellular Ca<sup>2+</sup> concentration with voltage sensitive dye (RH237) and Ca<sup>2+</sup> (Rhod-2) fluorescence probes. VF was induced by burst stimulation and the relationship between V<sub>m</sub> and Ca<sup>2+</sup> oscillations in VF were analyzed with cross-correlation analysis. The maximum correlation occurred at 12 ms delay between V<sub>m</sub> and Ca<sub>i </sub>, suggesting V<sub>m</sub> still triggers Ca<sup>2+</sup> release in VF as in normal excitation-contraction coupling. In addition, inverse correlation was found -20 ms between V<sub>m</sub> and Ca<sub>i</sub>, suggesting the amplitude of Ca<sub>i</sub> can modulate action potential recovery in VF. In conclusion, Ca<sub>i</sub> can influence action potential durations, which may promote wave breaks in VF
Effect of finishing and polishing procedures on the gap width between a denture base resin and two long-term, resilient denture liners.

STATEMENT OF PROBLEM The junction between a long-term, resilient denture liner and the denture base is difficult to finish and polish due to differences in the hardness of the materials. Gaps tend to form during finishing and polishing procedures. PURPOSE This study measured the junctional gap between 2 long-term, resilient denture liners and a denture base material after different finishing and polishing procedures were performed. The surface smoothness of the 2 liner materials also was evaluated. MATERIAL AND METHODS Molloplast-B and an experimental, heat-polymerized methyl siloxane-resin-based denture liner were processed (according to the manufacturer's instructions) against Lucitone 199 acrylic resin. Control specimens (n = 20) were 2 mm thick and flat. Experimental specimens (n = 64) were fabricated with a raised center section: a 3- x 5- x 15-mm half-cylindrical ridge with a junction at the top of the cylinder between the liner material and acrylic resin. The specimens were finished with 1 of 6 types of burs and polished with different combinations of rubber-impregnated acrylic polishers, pumice, and tin oxide. The finished specimens were examined and photographed with a scanning electron microscope, and the largest gap along the liner/denture base junction on each specimen was measured. Three-way analysis of variance without replication (P<.05) and post-hoc t tests were used to analyze the data and compare groups. RESULTS; Averaged across finishing and polishing techniques, a larger gap was recorded for the experimental liner material (22 microm) than for Molloplast-B (14 microm) (P<.00005). Qualitative evaluation suggested that the experimental liner material polished better than Molloplast-B. The smoothest surfaces were obtained when specimens were finished with fine-tooth cross-cut carbide burs and polished with both pumice and tin oxide. A comparison between polished and unpolished specimens, averaged over materials and finishing techniques, revealed that polishing reduced gap size (P=.015). CONCLUSION Within the limitations of this study, the 2 denture liners tested behaved similarly. The results suggest that the size of the gap at the liner/denture base junction may be affected by finishing and polishing techniques and vary among materials.
In Vivo and in Vitro Interactions of the Bombyx mori Chymotrypsin Inhibitor b1 with Escherichia coli

Various chymotrypsin inhibitors occur in the hemolymph of silkworm larvae. Interaction of chymotrypsin inhibitor b1 (CI-b1) with Escherichia coli was examined from the viewpoint of action against invading bacteria. Injection of dead E. coli cells into larva reduced the CI-b1 content of the hemolymph, suggesting in vivo binding of CI-b1 to the outer membrane of the cell. Results from incubation of E. coli in cell-free hemolymph in the presence or absence of lipopolysaccharide indicated that CI-b1 is the only CI bound to E. coli and that it interacts with lipopolysaccharide. CI-b1 formed a complex with lipopolysaccharide in vitro; the value of the dissociation constant was relatively large. Inhibitory activity of CI-b1 changed insignificantly in mixture with lipopolysaccharide. CI-b1 affected the growth of E. coli but never worked lethally. CI-b1 is speculated to be a mediator that scavenges intruding bacteria rather than a direct anti-bacterial factor. This is the first report confirming that CI-b1 is a lipopolysaccharide binding protein.
PCR amplification and restriction endonuclease analysis of a 65-kilodalton heat shock protein gene sequence for taxonomic separation of rapidly growing mycobacteria

A total of 129 reference and clinical strains of rapidly growing mycobacteria (RGM) belonging to 10 taxonomic groups were studied for restriction fragment length polymorphism patterns from a PCR-amplified 439-bp segment of the 65-kDa heat shock protein (HSP) gene. Of 24 endonucleases evaluated, restriction fragment length polymorphism patterns produced by HaeIII and BstEII and then by AciI and CfoI gave the best separation. Sixty percent of all RGM taxa studied were differentiated by HaeIII digests alone. Single unique patterns were observed with HaeIII and/or BstEII for Mycobacterium fortuitum (100%), M. chelonae (94%), M. abscessus (96%), M. smegmatis (100%), M. mucogenicum (formerly the M. chelonae-like organism) (100%), and the sorbitol-negative third biovariant of M. fortuitum (100%). Evidence is presented in support of two subgroups within M. peregrinum, M. smegmatis, and the unnamed third biovariant of M. fortuitum (sorbitol positive and sorbitol negative). PCR-based technology provides a rapid, accurate system for the identification of clinically important species of RGM which should be particularly useful for reference laboratories.
Measuring structural dynamics with smartphones

Dynamic analysis of structures plays an important role in designing civil engineering structures. Increasing population density and limited land availability have led to build taller, lighter and hence slender structures which attract high wind forces. Thus, there is an ever-growing demand for testing and monitoring dynamic responses of structures to understand performance under dynamic loading and estimate dynamic properties of structures. Since current techniques for dynamic testing are very costly, many avoid measuring dynamic responses until a problem arises. This paper presents a cost-effective method of dynamic measurements using readily available smartphones which are equipped with inbuilt accelerometers. A mobile application has been developed to acquire acceleration data from a smartphone and analyzed to estimate the dominant frequencies of a structure. Laboratory experiments has shown the potential of using smartphone as a reliable dynamic sensor.
Rearrangement of the PH‐20 protein on the surface of macaque spermatozoa following exposure to anti‐PH‐20 antibodies or binding to zona pellucida

Capacitated cynomolgus macaque sperm have a surface hyaluronidase (PH‐20) that is evenly distributed over the entire head and can be visualized at the ultrastructural level using a secondary antibody labeled with colloidal gold . Exposure of sperm to mono‐specific, bivalent polyclonal antibodies to PH‐20 causes a rapid clustering of PH‐20 . The predominant morphological consequence of PH‐20 redistribution is its aggregation along the lateral edge of the sperm head. Monovalent Fab fragments of the anti‐PH‐20 antibody bound to the sperm head but did not induce a change in PH‐20 distribution. PH‐20 aggregation was observed in almost all sperm following treatment with the polyclonal antibody, but only about 20% of the sperm had morphological acrosome reactions, regardless of the time of exposure or the concentration of antibody. There was morphological evidence of swelling of the acrosomal matrix in over 50% of the sperm following exposure to anti‐PH‐20 antibodies. Anti‐PH‐20 Fab fragments did not induce the acrosome reaction or acrosomal matrix swelling. Sperm bound to macaque zona pellucida also showed aggregation of the PH‐20 protein as soon as 30 sec after sperm‐zona interaction. This aggregation was not observed when macaque sperm were bound to hamster zona pellucida.
Fetal outcome after prenatal exposure to chemotherapy and mechanisms of teratogenicity compared to alcohol and smoking

Introduction: The treatment of cancer during pregnancy is challenging because of the involvement of two individuals and the necessity of a multidisciplinary approach. An important concern is the potential impact of chemotherapy on the developing fetus. Areas covered: The authors review the available literature on neonatal and long-term outcome of children prenatally exposed to chemotherapy. Chemotherapy administered during first trimester of pregnancy results in increased congenital malformations (7.5 – 17% compared to 4.1 – 6.9% background risk), whereas normal rates are found during second or third trimester. Intrauterine growth restriction is seen in 7 – 21% (compared to 10%), but children develop normal weight and height on the long term. Children are born preterm in 67.1%, compared to 4% in general population. Normal intelligence, attention, memory and behavior are reported, although intelligence tends to decrease with prematurity. Global heart function remains normal, although small differences are seen in ejection fraction, fractional shortening and some diastolic parameters. No secondary cancers or fertility problems are encountered, but follow up periods are limited. Expert opinion: Most evidence is based on retrospective studies with small samples and limited follow up periods, methodology and lack of control groups. A large prospective case–control study with long-term follow up is needed in which confounding factors are well considered.
The influence of mechanical function on the development and remodeling of the tibia. An experimental study in sheep.

Femoroacetabular impingement is recognized as a major cause of hip pain and early hip joint osteoarthritis in young adults. The dynamic conflict between the femoral neck and the acetabular rim has been shown to result in labral tears, cartilage lesions, and early osteoarthritis. To be successful, the treatment strategy should address the underlying pathomorphology at the femoral neck, the acetabulum, or both. An overview of the various pathomorphologies leading to femoroacetabular impingement and a treatment algorithm intended to preserve the native hip joint should be helpful to the orthopaedic surgeon treating patients with this condition.
The Current Situation and Sustainable Development of Water Resources in Bangladesh

Water is critical for human endurance, socio-economic improvement of the state and protection of its natural environment. This paper analyzes the present day state of affairs and problems of water resources in Bangladesh. The goal of this study is aimed on sustainable development of water assets in Bangladesh. The information is collected from the secondary sources and statistics available such as books and internet.
Ligands for EPH‐related tyrosine kinase receptors are developmentally regulated in the CNS

Elk is a member of the eph family of receptor‐like tyrosine kinases. Although its function is unknown, elk is postulated to play a role in nervous system development. Using Northern analysis, we examined the developmental regulation of RNAs encoding elk, and several ligands for the eph family of RTKs, the LERKs. Expression of elk, LERK‐1, and LERK‐2 RNAs is high in all regions examined in the embryonic and postnatal rat brain and decreases to low levels with age. One exception is the adult olfactory bulb which continues to express a moderate level of LERK‐2. In contrast, moderate LERK‐4 expression was limited to the developing hippocampus and cerebral cortex. These data indicate that elk and some of the LERKs may play a role in nervous system development, maintenance, and/or regeneration. © 1995 Wiley‐Liss, Inc.
ABSTRACTION FOR DATA INTEGRATION: FUSING MAMMALIAN MOLECULAR, CELLULAR AND PHENOTYPE BIG DATASETS FOR BETTER KNOWLEDGE EXTRACTION

With advances in genomics, transcriptomics, metabolomics and proteomics, and more expansive electronic clinical record monitoring, as well as advances in computation, we have entered the Big Data era in biomedical research. Data gathering is growing rapidly while only a small fraction of this data is converted to useful knowledge or reused in future studies. To improve this, an important concept that is often overlooked is data abstraction. To fuse and reuse biomedical datasets from diverse resources, data abstraction is frequently required. Here we summarize some of the major Big Data biomedical research resources for genomics, proteomics and phenotype data, collected from mammalian cells, tissues and organisms. We then suggest simple data abstraction methods for fusing this diverse but related data. Finally, we demonstrate examples of the potential utility of such data integration efforts, while warning about the inherit biases that exist within such data.
Contribution à la méthodologie de conception système : application à la réalisation d'un microsystème multicapteurs communicant pour le génie civil

Ce travail de these porte sur la problematique de conception et de realisation d'un microsysteme multicapteur communicant pour une application Genie Civil. Ces travaux ont associe le LAAS-CNRS et EDF R&D. Il presente et definit la problematique de recherche et de developpement de nouvelles generations d'outils pour la conception systeme et traite conjointement un exemple d'application proposant notamment une solution de mesure de microdeplacement sur site. Ce manuscrit fait d'abord le point sur la dynamique de developpement microsysteme et rappelle les methodes de conception et d'integration de systemes a base de composants COTS. Le projet qui nous concerne est ensuite presente et analyse par la methode de l'analyse du besoin pour etablir un cahier des charges, porte d'entree de la demarche generale de conception. Il montre, sur l'exemple propose, les etapes que nous avons conduites pour atteindre le stade des specifications validees. La methodologie de conception amont proposee associe la demarche Top-Down et SysML pour reduire au maximum le lien entre le cahier des charges et la premiere representation modelisee du systeme. Cette modelisation amont, independante de l'implementation, est effectuee sous l'outil HiLeS et ouvre la voie de la premiere verification du systeme, par le biais de la logique temporelle. Ensuite, les choix d'agregation, de selection et d'implementation des composants sont decrits et permettent d'aboutir a la modelisation fonctionnelle sous VHDL-AMS et au prototypage virtuel. Enfin, ce travail presente les etapes d'integration et les choix de composants qui menent au prototype reel. Une premiere validation de ce prototype realise est effectuee par des mesures sur site.
A comparison of three treatment strategies for locally advanced and borderline resectable pancreatic cancer.

BACKGROUND The optimal treatment strategy for locally advanced and borderline resectable pancreatic cancer is not known. We compared overall survival (OS), local control (LC), metastasis free survival (MFS), and percent of patients who were able to undergo successful surgical resection for three treatment strategies. METHODS We retrospectively reviewed 115 sequentially treated cases of locally advanced (T4) or borderline resectable (T3 but unresectable) pancreatic cancer. Patients were treated with either chemotherapy alone (C), concurrent chemoradiation therapy (CRT), or chemotherapy followed by chemoradiation therapy (CCRT). We compared survival between groups using Kaplan-Meier analysis and Cox-proportional hazards models. RESULTS Median follow-up was 18.7 months. Fifty-six (49%) patients had locally advanced disease. Of the patients who received chemotherapy up-front, 82/92 (89%) received gemcitabine-based chemotherapy. Of the patients receiving C alone, 11/65 (17%) were diagnosed with distant metastases or died before 3 months. The rate of successful surgical resection was 6/50 (12%) in patients treated with radiation therapy (CRT or CCRT). Median survival times for patients undergoing C, CRT, and CCRT were 13.9, 12.5, and 21.5 months respectively. Patients treated with CCRT experienced statistically significant improved OS and MFS compared to C alone (P=0.003 and P=0.012 respectively). There was no difference in LC between treatment groups. On multivariable analysis younger age (P=0.009), borderline resectable disease (P=0.035), successful surgery (P=0.002), and receiving chemotherapy followed by chemoradiation therapy (P=0.035) were all associated with improved OS. CONCLUSIONS Treatment with CCRT is associated with improved median OS and MFS compared with C alone. This strategy may select for patients who are less likely to develop early metastases and therefore have a better prognosis.
Cultural Audits: Multiple Mixed Methods in Action

The case study provides an analysis of the development of exploratory sequential mixed- methods research into issues of equal opportunities in the form of a cultural audit. The research was constructed from first principles, and the various stages are presented in detail. At the cornerstone was the construction and implementation of a questionnaire given to all members of the organization. This was premised upon and complemented by a wide range of other methods. These included interviews, focus groups, and documentary research. Some of the questions used were taken from earlier national surveys, and these facilitated the triangulation of the results of the cultural audit with known national patterns of values and attitudes. The case study also outlines how the cultural audit provided powerful instruments for effective human resources management.
Proceedings of the Eighteenth Annual ACM-SIAM Symposium on Discrete Algorithms, SODA 2007, New Orleans, Louisiana, USA, January 7-9, 2007

The papers in this volume were presented at the Eighteenth Annual ACM-SIAM Symposium on Discrete Algorithms, held January 7--9, 2007, in New Orleans, Louisiana. The Symposium was jointly sponsored by the SIAM Activity Group on Discrete Mathematics and by SIGACT, the ACM Special Interest Group on Algorithms and Computation Theory. In response to the call for papers, a total of 382 papers were submitted, one of which was subsequently withdrawn. The program committee accepted 139 submissions, which included four pairs of papers that were subsequently merged. This resulted in 137 papers in the conference proceedings and 135 presentations at the conference. The decisions were based on originality, technical contribution, and relevance. In addition to the program committee members, over 400 members of the community contributed to the selection process by reviewing papers; many of these researchers reviewed a number of different submissions. The submissions were not formally refereed, although every attempt was made to verify the main claims. It is expected that most of the accepted papers will appear in more complete form in scientific journals.
The Effect of Website Age on Reported Cash Flows

Websites are one of the most debated technologies in business. After the recent dotcom bust, many argue that websites lack value in commercial environments. Cash flow, essential to a business' health, is often a reliable indicator of income opportunities. Yet the link between cash flows and website ownership has never been satisfactorily made. This paper explores the relationship between cash flows, website use and maturity by examining factors such as website age, number of IT employees, total assets and market capitalisation. The study finds that website ownership and maturity do not explain cash flows, except for companies in IT industries.
EFFECT OF THE ANTIBACTERIAL SERUM FACTOR ON STAPHYLOCOCCAL INFECTIONS

Yotis, W. W. (Loyola University Medical School, Chicago, Ill.). Effect of the antibacterial serum factor on staphylococcal infections. J. Bacteriol. 83:137–143. 1962—Intracerebral injections of mice with 1 to 5 × 106 washed viable cells previously exposed for 1 hr at 4 C to 2 mg/ml of the serum factor resulted in 0 to 30% mortality when three recent isolates of yellow, hemolytic, coagulase-positive strains of Staphylococcus aureus were used. Mice inoculated in the same manner with the above strains, but exposed to an inactive preparation of the serum factor, showed a 60 to 90% mortality. Addition of partially purified coagulase to the serum factor neutralized the protective action of the serum factor. The serum factor was found primarily in the supernatant obtained following 62% (NH4)2SO4 saturation of the water-soluble globulin portion and precipitated by one-half volume of undiluted 95% ethanol. Plate counts, manometric techniques, and animal protection studies were employed to follow purification of the serum factor. If dry weight is taken as the criterion of purification, the active substance showed a 40-fold purification over a previous preparation of this substance.