Miracle-dz/UniFAR-FTUs huggingface dataset:
Existing Trends and Techniques for Web Personalization

In the recent few decades the World Wide Web has become the biggest and most popular way of communication and information dissemination. World Wide Web is a huge repository of web pages and links and the volume of information available on the internet is increasing exponentially as approximately one million pages are added daily. The existence of such abundance of information, in combination with the dynamic and heterogeneous nature of the web, makes web site exploration a difficult process for the average end user. So in spite of the fact that users are provided with more information and service options, the average end users may not get the “right” information only, in what they are interested in. with the explosive growth of the number and the complexity of information resources and the advent of eservices; it has become more difficult to access relevant information from the Web. One of the recent advances throughout this decade has been the evolution of the web personalization to address the requirement of effective web navigation and now the web personalization has become an indispensable tool for both Web-based organizations and for the end users to deal with the content overload. In this paper we highlight a comprehensive overview of the personalization process and various web personalization Techniques and the significance of studying the evolving nature of the Web personalization because most major internet companies are implementing their personalization systems. Since a lot of
Brain/MINDS: brain-mapping project in Japan

There is an emerging interest in brain-mapping projects in countries across the world, including the USA, Europe, Australia and China. In 2014, Japan started a brain-mapping project called Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS). Brain/MINDS aims to map the structure and function of neuronal circuits to ultimately understand the vast complexity of the human brain, and takes advantage of a unique non-human primate animal model, the common marmoset (Callithrix jacchus). In Brain/MINDS, the RIKEN Brain Science Institute acts as a central institute. The objectives of Brain/MINDS can be categorized into the following three major subject areas: (i) structure and functional mapping of a non-human primate brain (the marmoset brain); (ii) development of innovative neurotechnologies for brain mapping; and (iii) human brain mapping; and clinical research. Brain/MINDS researchers are highly motivated to identify the neuronal circuits responsible for the phenotype of neurological and psychiatric disorders, and to understand the development of these devastating disorders through the integration of these three subject areas.
MAKING UP OR BREAKING UP: THE TORTUOUS ROLE OF PLATELET‐DERIVED GROWTH FACTOR IN VASCULAR AGEING

1 Ageing has long been recognized as an independent risk factor for the development of cardiovascular diseases, contributing to high cardiovascular morbidity and mortality. Age‐associated remodelling of the vascular wall includes luminal enlargement, intimal and medial thickening and vascular stiffness. 2 A growing body of evidence has indicated that the migration and proliferation of vascular smooth muscle cells (VSMC) play a pivotal role in the pathophysiological vascular ageing process. Both experimental and clinical evidence implicates platelet‐derived growth factor (PDGF) as having an essential role in the proliferation of VSMC, an early pathological feature of arteriosclerosis and vascular ageing. 3 In the present review, we summarize some of the recent progress made with regard to defining the role of PDGF in the proliferation of VSMC and vascular ageing, with an emphasis on the cell signalling mechanisms involved.
Continuously Produced Electrically Conducting Silk Fibers and Their Integration into Functional Fabrics

Conducting yarns are of interest for different applications because of their capability to be incorporated into textiles making electronic devices that later can, for example, be used to convert waste heat into electricity. The research available at the present declared that these conducting PEDOT: PSS yarns were produced batch-wise. Therefore, it was of significance to develop a method for continuous dyeing for the production of conducting silk yarns. In this project a continuously PEDOT: PSS dyed yarn was produced with high conductivity which maintained its properties upon mechanical testing and industrial processing. To produce these dyed threads different parameters were investigated to provide an optimal conductivity. By directing the thread through a dye bath, superior results in conductivity were achieved. Prewashing a degummed silk yarn in water in combination with small amounts of detergent and ammonia proved to increase the interaction between the coating and the fibers. Further enhancement in conductivity was achieved by the addition of ethylene glycol, as a secondary dopant, to the PEDOT: PSS dye bath. The addition of post-treatment with dimethyl sulfoxide (DMSO) enhanced the conductivity of the dyed yarn by two orders of magnitude compared to a nonsecondary doped/post-treated dyed yarn. Additionally, increasing the viscosity of the dye bath in combination with multiple layers of coating improved the conductivity to a value of 74 S/cm and a Seebeck coefficient of 15 μV/K. More than 100 m dyed yarn was produced and the thread was manually woven into a keyboard with alternating conductive sections and non-conductive parts. The dyed thread was connected to a light source and a battery which showed that the thread could conduct current. Additionally, the yarn was both industrially embroidered and woven which illustrated that the thread could survive industrial processing. Washing decreased the resistance of the embroidered textile meaning that the thread could be used in wearable textiles. For future studies, the hope is to integrate the conducting yarn in thermoelectric devices.
Clinical outcome of chronic myeloid leukemia imatinib-resistant patients: do BCR–ABL kinase domain mutations affect patient survival? First multicenter Argentinean study

In imatinib-treated patients with chronic myeloid leukemia (CML), BCR–ABL mutations are the most common mechanism of resistance. Here we report the first multicenter Argentinean study investigating mutations in those patients with CML who fail or lose response to imatinib, with or without previous interferon treatment. Point mutations were detected in 36 of 154 patients by direct sequencing. In our series, the single most common mutations were G250E, E255K/V, and M351T. The presence of mutations correlated significantly with accelerated phase, lack of molecular response, and lower cytogenetic and hematological responses. While overall survival did not differ between patients with or without mutations, the probability of progression was higher in patients with mutations. Cases with non-P-loop mutations showed a significantly better overall survival from diagnosis. Multivariate analysis showed that the most significant variables related to the development of mutations were accelerated phase, duration of imatinib treatment, and time delay to starting imatinib. Our results demonstrated that mutation frequency increased with the progression of disease, and suggest that imatinib treatment should be started early.
Cardiac mechanoenergetics in silico.

The aim of this thesis is to investigate the link between biochemical intracellular processes and mechanical contraction of the cardiac muscle. First, the regulation of intracellular energy fluxes between mitochondria and myofibrils is studied. It is shown, that the experimentally observed metabolic stability of the cardiac muscle is reproducible by a simple feedback regulation mechanism, i.e., ATP consumption in myofibrils and ATP production in mitochondria are balanced by the changes of the high energy phosphate concentrations. Second, an important property of energy transformation from biochemical form to mechanical work in the cardiac muscle, the linear relationship between the oxygen consumption and the stress-strain area, is replicated by a cross-bridge model. Third, by using the developed cross-bridge model, the correlation between ejection fraction of the left ventricle and heterogeneity of sarcomere strain, developed stress and ATP consumption in the left ventricular wall is established. Fourth, an experimentally observed linear relationship between oxygen consumption and the pressure-volume area can be predicted theoretically from a linear relationship between the oxygen consumption and the stress-strain area. Summing up, it is shown how the macrovariables of a cardiac muscle are interwoven with intracellular physiological processes into a whole.
Simple and effective visual models for gene expression cancer diagnostics

In the paper we show that diagnostic classes in cancer gene expression data sets, which most often include thousands of features (genes), may be effectively separated with simple two-dimensional plots such as scatterplot and radviz graph. The principal innovation proposed in the paper is a method called VizRank, which is able to score and identify the best among possibly millions of candidate projections for visualizations. Compared to recently much applied techniques in the field of cancer genomics that include neural networks, support vector machines and various ensemble-based approaches, VizRank is fast and finds visualization models that can be easily examined and interpreted by domain experts. Our experiments on a number of gene expression data sets show that VizRank was always able to find data visualizations with a small number of (two to seven) genes and excellent class separation. In addition to providing grounds for gene expression cancer diagnosis, VizRank and its visualizations also identify small sets of relevant genes, uncover interesting gene interactions and point to outliers and potential misclassifications in cancer data sets.
Tree of Life Based on Genome Context Networks

Efforts in phylogenomics have greatly improved our understanding of the backbone tree of life. However, due to the systematic error in sequence data, a sequence-based phylogenomic approach leads to well-resolved but statistically significant incongruence. Thus, independent test of current phylogenetic knowledge is required. Here, we have devised a distance-based strategy to reconstruct a highly resolved backbone tree of life, on the basis of the genome context networks of 195 fully sequenced representative species. Along with strongly supporting the monophylies of three superkingdoms and most taxonomic sub-divisions, the derived tree also suggests some intriguing results, such as high G+C gram positive origin of Bacteria, classification of Symbiobacterium thermophilum and Alcanivorax borkumensis in Firmicutes. Furthermore, simulation analyses indicate that addition of more gene relationships with high accuracy can greatly improve the resolution of the phylogenetic tree. Our results demonstrate the feasibility of the reconstruction of highly resolved phylogenetic tree with extensible gene networks across all three domains of life. This strategy also implies that the relationships between the genes (gene network) can define what kind of species it is.
Carboxylated Carbon Nanotubes/Polyethersulfone Hollow Fiber Mixed Matrix Membranes: Development and Characterization for Enhanced Gas Separation Performance

Carboxylated carbon nanotubes (C or cCNTs) were incorporated in polyethersulfone hollow fiber membranes (P HFMs) to improve the gas separation performance, i.e., pure gas permeability and ideal gas selectivity. The developed CP HFMs showed the remarkable improvement in thermal stability and mechanical strength as compared to that of the pristine P HFMs. The pure gas permeability of CO_2, CH_4, O_2, and N_2 gases for the HFMs were measured at 3 bar feed pressure and room temperature. It was observed that the presence of cCNTs in HFMs significantly improved the CO_2 and O_2 permeability for CP HFMs by 10.8-and 11.7- fold, respectively, as compared to that measured for P HFMs. Furthermore, the ideal gas selectivity for CO_2/CH_4, O_2/N_2, and CO_2/N_2 gas pairs for CP HFMs was also remarkably enhanced by almost 8.6-, 10.7-and 9.9-times, respectively, as compared to that measured for P HFMs. CP HFMs exhibited gas separation performance better than or comparable to that of the literature-reported CNTs-based membranes. Remarkably, the gas separation performance of CP HFMs crossed Robeson’s 2008 upper bound curve for O_2/N_2 gas-pair and was almost closer to the upper bound curves drawn by Robeson in 2008 for CO_2/CH_4 and CO_2/N_2 gas pairs. The improved separation performance can be attributed to the presence of cCNTs in HFMs. Thus, the results obtained in this study clearly showed that the CP HFMs can potentially be used as a membrane material for the industrially relevant gas separations.
Testing Replica Selection Policies in a Pan-European Grid VO

In a typical grid environment, replicas are spread over storage hosts, so as to increase availability and reduce files transfer times. Generally, the grid middleware lets users choose the storage host that will be serving the replica. However, having users able to choose could adversely affect network conditions and increase transfer times. This paper proposes two replica selection policies that choose one among the storage hosts holding a requested replica. The selection policies try to minimise file transfer time by extracting the least loaded host or the closest among unloaded hosts. It is shown that overall performances for transferring replicas depend on network topology, latency and bandwidth of links, and load of storage hosts and links.
Vincristine and carboplatin chemotherapy for unresectable and/or recurrent low‐grade astrocytoma of the brainstem

Radiotherapy remains a widely accepted postoperative treatment modality for unresectable or recurrent low‐grade glioma (LGG). However, there is increasing evidence to suggest that chemotherapy can delay and may obviate the need for radiotherapy in progressive/recurrent LGG. The majority of the published experience is in children with hypothalamic/optic chiasmatic lesions and little information is available regarding its use in LGG of the brainstem.
Bacterial Probiotics Induce an Immune Response in the Honey Bee (Hymenoptera: Apidae)

Abstract To explore immune system activation in the honey bee, Apis mellifera L. , larvae of four ages were exposed through feeding to spores of a natural pathogen, Paenibacillus larvae larvae, to cells of a diverse set of related nonpathogenic bacteria, and to bacterial coat components. These larvae were then assayed for RNA levels of genes encoding two antibacterial peptides, abaecin and defensin. Larvae exposed to either P. l. larvae or a mix of nonpathogenic bacteria showed high RNA levels for the abaecin gene relative to controls. First instars responded significantly to the presence of the nonpathogenic mix within 12 h after exposure, a time when they remain highly susceptible to bacterial invasion. This response was sustained for two successive instars, eventually becoming 21-fold higher in larvae exposed to probiotic spores versus control larvae. The mixture of nonpathogenic bacteria is therefore presented as a potential surrogate for assaying the immune responses of different honey bee lineages. It also is proposed that nonpathogenic bacteria can be used as a probiotic to enhance honey bee immunity, helping bee larvae, and other life stages, survive attacks from pathogens in the field.
Lymphocyte sensitization to nervous tissues and muscle in patients with the Guillain-Barré syndrome

By means of an electrophoretic method lymphocytes from patients with the Guillain-Barré syndrome (`acute idiopathic polyneuritis') have been shown to be sensitized to both encephalitogenic factor (EF) and a similar basic protein prepared from human sciatic nerve (SNBP). Sensitization was more marked in the acute stage of the disorder during which there also appeared to be a degree of sensitization to muscle. The results are consistent with the view that lymphocytic infiltration of peripheral nerves in the condition is of pathogenetic significance.
TCMP-a modulation and coding strategy for Rician fading channels

The authors describe TCMP, a novel modulation strategy for Rician fading channels that multiplexes a time domain pilot sequence with trellis-coded data to permit coherent detection. This technique is shown to provide remarkably robust performance in the presence of fading. It is also shown that, when choosing trellis codes for fading channels, time diversity is of greater important than asymptotic coding gain. The motivation for studying this strategy is to find signaling schemes for transmitting data at a 4.8 kb/s rate over a mobile satellite channel with 5-kHz channel spacing. >
CHARACTERISTICS OF LIQUID SMOKE FROM THE PYROLYSIS OF DURIAN PEEL WASTE AT MODERATE TEMPERATURES

As a tropical country, Indonesia possesses abundant natural resources including a variety of plants. One of these interesting plants is durian (Durio zibethinus), which produces a large amount of biomass waste. High durian consumption results in a significant amount of peel waste. Similar to other biomass waste, durian peel contains cellulose, hemicellulose, and lignin, which are the main components that form liquid smoke. Durian peel pyrolysis is one method that can be used to produce liquid smoke, which can be used as a natural preservative, latex coagulant, and biopesticide. This research aimed to characterize liquid smoke generated from durian peel waste at moderate temperatures using the slow pyrolysis method. The batch reactor that was used has a 5 kg capacity and was run at temperatures of 300C, 340C, and 380C. The chemical compounds contained in the liquid smoke were tested quantitatively using gas chromatography-mass spectrometry (GC-MS). The acetic acid and phenol were tested, qualitatively, using high performance liquid chromatography (HPLC). GC-MS results showed that more than 15 chemical compounds were detected in the liquid smoke, including phenolic acid, carbonyl, carboxylate, furan, and acid compounds, among others. The pyrolysis temperature greatly influences the resulting liquid smoke components, especially the composition of phenol and acetate. The highest phenol content (2%) was found in the liquid smoke that resulted from pyrolysis at 300C; while the highest acetic acid content (8%) was found in the liquid smoke that resulted from pyrolysis at 380C.
Probabilistic analysis of anonymity

We present a formal analysis technique for probabilistic security properties of peer-to-peer communication systems based on random message routing among members. The behavior of group members and the adversary is modeled as a discrete-time Markov chain, and security properties are expressed as PCTL formulas. To illustrate feasibility of the approach, we model the Crowds system for anonymous Web browsing, and use a probabilistic model checker, PRISM, to perform automated analysis of the system and verify anonymity guarantees it provides. The main result of the Crowds analysis is a demonstration of how certain forms of anonymity degrade with the increase in group size and the number of random routing paths.
Structural damages disturb functional improvement in patients with rheumatoid arthritis treated with etanercept

Tumor necrosis factor (TNF) inhibitors have produced improvements in clinical, radiographic, and functional outcomes in rheumatoid arthritis (RA) patients. However, it remains unclear whether factors affecting physical functions remain following TNF therapy. The objective of our study was to assess factors affecting improvement of physical functions and to shed light on relations to disease activity and structural changes in patients with RA treated with etanercept. The study enrolled 208 patients, all of whose composite measures regarding clinical, radiographic, and functional estimation both at 0 and 52 weeks after etanercept therapy were completed. Mean disease duration of 208 patients was 9.6 years, mean Disease Activity Score for 28 joints (DAS28) was 5.4, and mean van der Heijde modified total Sharp score (mTSS) was 94.6. Mean Health Assessment Questionnaire Disability Index (HAQ-DI) improved from 1.4 at 0 weeks to 1.0 at 52 weeks after etanercept therapy, a 31% reduction, which was much less than changes in DAS28 and mTSS. By multivariate analysis, HAQ-DI and mTSS at baseline were significantly correlated HAQ remission. Median HAQ-DI improved in 100 versus 20% of the HAQ-DI ≤0.6 versus ≥2.0 groups, respectively. The mTSS cutoff point at baseline to obtain HAQ remission was 55.5. During etanercept treatment in the mTSS <55.5 versus >55.5 groups, median HAQ-DI improved in 70 versus 39%; remission was achieved in 59 versus 33%; and there was no improvement in14 versus 30%, respectively. HAQ-DI improvement was significantly correlated with that of DAS28 but not of mTSS. In conclusion, higher HAQ and mTSS at baseline inhibits HAQ-DI improvement within 1 year of etanercept treatment, and the cutoff point necessary for mTSS to improve physical functions in patients with RA was 55.5.
Plasmonic responses of metallic/dielectric core-shell nanoparticles on a dielectric substrate

The effect of material selection on the plasmonic response and local absorption are evaluated for core–shell nanoparticles placed over a BK7 glass substrate. Eight different core–shell pairs are studied using the vectorized version of discrete dipole approximation with surface interactions (DDA-SI). Two classes of dielectric core-metallic shell and metallic core-dielectric shell particles are considered. It is shown that core–shell structures with dielectric materials can have absorption enhancement compared to the bare metallic nanoparticles. Moreover, it is observed that core–shell pairs yield multipeak localized surface plasmon resonance (LSPR) response due to their hybrid structure. Absorption enhancement and LSPR tuning ranges are shown with different dielectric materials that can be used in localized heating of designated core–shell NPs placed over a surface for nanomanufacturing purposes. In order to determine the optimum size configurations, a number of core–shell pairs are explored with specified volumetric filling ratio of core materials.
Verification of the flexion and shear behavior in masonry panels accordance to ABNT NBR 15961-1 (2011), EN 1996-1-1 (2005) and ACI TMS 530 (2013)

Abstract This paper presents a numerical analysis of the mechanical behavior of structural masonry panels submitted to horizontal and vertical stresses. To evaluate the design process of these structures, the results obtained by the computer simulations were compared with the results determined by the design criteria of ABNT NBR 15961-1 (2011), ACI TMS 530 (2013) and EN 1996-1-1 (2005). The finite element software DIANA v.9. 3 was used to simulate two-dimensional models with the simplified micro modelling procedure. The results obtained by the normative standards were more conservative than the results of the numerical model, as expected. With the increase of the pre-compression level, the computer simulation has demonstrated the increasing trend of the values of resistant forces, besides the change of the way of rupture of the panels. Among the three standards evaluated, the American Standard was the most conservative.