Miracle-dz/UniFAR-FTUs huggingface dataset:
Host Plant Resistance (HPR) to Insect Pests

Conventional breeding in conjunction with molecular techniques and transgenic approaches have a great promise to reduce pest associated crop losses, and accelerate the progress in developing cultivars with resistance to insects. Although, considerable progress has been made over the past two decades in manipulating genes from diverse sources to develop plants with resistance to insect pests, rapid and cost effective development and adoption of biotechnology derived products will depend on developing a full understanding on the interaction of genes within their genomic environment, and with the environment in which their conferred phenotype interact. A good beginning has been made in developing genetic linkage maps of many crops, but the accuracy and precision of phenotyping for resistance to insect pests r emains a critical constraint in many crops.
AHEad: Privacy-preserving online behavioural advertising using homomorphic encryption

Online advertising is a rapidly growing industry, forming the primary source of income for many publishers that offer free web content. The practice of serving advertisements based on individuals' interests greatly improves the expected effectiveness of advertisements, and is believed to be beneficial to publishers and users alike. However, the widespread data collection required for such behavioural advertising sparks concerns over user privacy. In this paper, we present AHEad, a privacy-preserving protocol for Online Behavioural Advertising that ensures user privacy by processing data in encrypted form. AHEad combines homomorphic encryption with a machine learning method commonly encountered in existing advertising systems. Advertisements are served based on detailed user profiles, while achieving performance linear in the size of user profiles. To the best of our knowledge, AHEad is the first protocol that preserves user privacy in behavioural advertising while allowing the use of detailed user profiles and machine learning methods.
Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein

Humans harboring missense mutations in the presenilin 1 (PS1) gene undergo progressive cerebral deposition of the 42-residue amyloid beta-protein (A beta 42) at an early age and develop severe Alzheimer's disease. A beta 42 is selectively elevated in the conditioned media of cells expressing mutant but not wild-type PS1, indicating that presenilin mutations alter APP processing. Here we analyze the effects of various PS1 mutant constructs on the cellular production of A beta 42. A construct expressing only the PS1 N-terminal endoproteolytic fragment with the mutation Y115H causes no significant increase in A beta 42, whereas a full-length PS1 construct with the same mutation does. This result suggests that the pathogenic effect of mutant presenilins is produced by the full-length molecule even though only a minor proportion of total PS1 occurs as holoprotein in tissues and cell lines. We demonstrate that the effects of two different PS1 mutations are additive when engineered into the same PS1 molecule. Therefore, two mutations alter gamma-secretase processing of APP more than one and the PS1 mutations described to date do not cause the maximum possible PS1-mediated rise in A beta 42. When a PS1 mutation was expressed in cells carrying the APPV717I mutation, A beta 42 rose dramatically to become the predominant secreted A beta species, an observation of interest for transgenic modeling of AD. Our results are consistent with the hypothesis that presenilin is a major regulator of the proteolytic processing of APP by gamma-secretases.
Paraphrasing verbal metonymy through computational methods

Verbal metonymy has received relatively scarce attention in the field of computational linguistics despite the fact that a model to accurately paraphrase metonymy has applications both in academia and the technology sector. The method described in this paper makes use of data from the British National Corpus in order to create word vectors, find instances of verbal metonymy and generate potential paraphrases. Two different ways of creating word vectors are evaluated in this study: Continuous bag of words and Skip-grams. Skip-grams are found to outperform the Continuous bag of words approach. Furthermore, the Skip-gram model is found to operate with better-than-chance accuracy and there is a strong positive relationship (phi coefficient = 0.61) between the model's classification and human judgement of the ranked paraphrases. This study lends credence to the viability of modelling verbal metonymy through computational methods based on distributional semantics.
Validating the Effects of Brand Quality on Attitude and Purchase Intention in Service–Product Alliances

ABSTRACT The purpose of this article is to replicate the findings of previous research studying the effects of brand quality on consumer attitude and purchase intentions in service–product encounters. The main contribution of the current research is to improve the generalizability of the previous findings by basing the experimental inquiry on real-world brands. Drawing on information integration and categorization theories, a set of hypotheses are presented that predict both mediating and moderating relationships between the independent and dependent variables. Results from an experimental study confirm previous findings, demonstrating that the quality of a product brand in a service–product alliance has significant effects on the attitude toward the service brand. Such effects are moderated by the quality of the service brand. Alternatively, service brand attributes do not have the same effect on component product brands included in the performance of that service. Service and product quality exhibit the same effects on purchase intentions as mediated by attitude.
First Whole-Genome Sequence of a Haemophilus influenzae Type e Strain Isolated from a Patient with Invasive Disease in Italy

ABSTRACT In the present era of conjugate vaccines against Haemophilus influenzae type b, non-vaccine-preventable strains are of concern. Here, we report the first whole-genome sequence of an invasive H. influenzae type e strain. This genomic information will enable further investigations on encapsulated non-type b H. influenzae strains.
A 5.3 pJ/pulse impulse-radio ultra-wideband pulse-generator for band group # 6

A low-power on-off-keying impulse-radio (IR) ultra-wideband (UWB) pulse generator (PG) operating at band group # 6 is presented. It is intended for IR-UWB radio applications. The IR signal is generated by utilizing the propagation delay of a delay-line and shaping its output. An on-chip inductor is used to tune out the output parasitic capacitance, hence the power consumption is reduced. Successfully implemented in a TSMC 90 nm CMOS process, measurements results show an energy consumption of 5.3 pJ/pulse with a 1.2 V supply. The pulse width and -10-dB bandwidth are 890 ps and 1.8 GHz respectively. The core area is 0.082 mm2.
Spartan 6 FPGA implementation of 2D-discrete wavelet transform in Verilog HDL

The paper gives us, a brief account of the design of 2D - discrete wavelet transform (DWT) implemented in VLSI architecture using Verilog HDL which achieves high speed computation. The main motive behind the development of the architecture is on giving efficient hardware utilization along with high operating speed and less number of clock cycles. To verify the proposed scheme, 2D DWT is applied on a grey image of size 128*128 to get all the four components (average, diagonal, horizontal and vertical), this wavelet decomposition is verified and obtained in Xilinx 14.2 version software using Verilog HDL; circuit is planned, modelled (simulated) in Verilog HDL, and finally the result is validated in FPGA Spartan 6 to get the output 2D-DWT computed image back. This is a single chip implementation where discrete wavelet transform can be used in VLSI design more efficiently than other transform. It is depicted that the operation carried out with specified processing speed of the designed architecture based on the proposed scheme is good than those of the other architectures designed using other existing schemes, and it has less hardware utilization.
Integrated Optical Systems for Laser Nanosurgery and Optical Trapping to Study Cell Structure and Function

L. Z. Shi, Q. Zhu, T. Wu, M. L. Duquette, V. Gomez, C. Chandsawangbhuwana, M. S. Harsono, N. Hyun, N. Baker, J. Nascimento, Z. You, E. B. Botvinick and M. W. Berns Institute of Engineering in Medicine, University of California, San Diego, 9500 Gilman Dr. SERF 295, MC 0435 La Jolla, CA 92093, USA Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, CA 92612, USA Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr. SERF 295, MC 0435 La Jolla, CA 92093, USA Department of Electrical Engineering, University of California, San Diego, 9500 Gilman Dr. SERF 295, MC 0435 La Jolla, California 92093, USA Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8228, St. Louis, MO 63110, USA
Isolation of two regions on rat chromosomes 5 and 18 affecting mammary cancer susceptibility

We previously mapped several quantitative trait loci (QTLs) controlling DMBA‐induced mammary tumor development in female rats derived from a SPRD‐Cu3 (susceptible strain) × WKY (resistant strain) cross. Two of these QTLs were assigned to chromosomes 5 and 18. In the present study, we generated and characterized congenic strains in which a segment of WKY chromosomes 5 or 18 was introduced in the SPRD‐Cu3 genetic background, thereby physically demonstrating that each of these two chromosomes controls mammary tumor multiplicity. The chromosome 5 QTL (Mcstm1) accounts for 7 tumors per animal (versus a total of 11 tumors per SPRD‐Cu3 rat). The chromosome 18 QTL (Mcstm2) accounts for 3 tumors per animal and is the first chemically‐induced mammary cancer susceptibility locus assigned to this chromosome. In addition, the Mcstm1 region was shown to also controls tumor latency. These loci thus play a major role in chemically‐induced mammary tumor development. QTLs controlling chemically‐induced or estrogen‐induced mammary tumor development have independently been identified on chromosomes 5 and 18, using susceptible strains others than SPRD‐Cu3. Therefore the haplotype structure of the relevant chromosome regions was analyzed in the different strains. Some chromosome regions were found to be highly mosaic (haplotype blocks < 1 Mb), while one region showed an apparently conserved haplotype block of 7.5 Mb. This analysis points to limited regions that could harbor the causative genes and also indicates that at least Mcstm2 is a novel QTL. © 2007 Wiley‐Liss, Inc.
Role of Campylobacter jejuni potential virulence genes in cecal colonization.

Campylobacter jejuni, a common commensal in chickens, is one of the leading causes of bacterial gastroenteritis in humans worldwide. The aims of this investigation were twofold. First, we sought to determine whether mutations in the C. jejuni ciaB and pldA virulence-associated genes impaired the organism's ability to colonize chickens. Second, we sought to determine if inoculation of chicks with C. jejuni mutants could confer protection from subsequent challenge with the C. jejuni wild-type strain. The C. jejuni ciaB gene encodes a secreted protein necessary for the maximal invasion of C. jejuni into cultured epithelial cells, and the pldA gene encodes a protein with phospholipase activity. Also included in this study were two additional C. jejuni mutants, one harboring a mutation in cadF and the other in dnaJ, with which we have previously performed colonization studies. In contrast to results with the parental C. jejuni strain, viable organisms were not recovered from any of the chicks inoculated with the C. jejuni mutants. To determine if chicks inoculated with the C. jejuni mutants become resistant to colonization by the C. jejuni parental strain upon subsequent challenge, chicks were inoculated either intraperitoneally (i.p.) or both orally and i.p. with the C. jejuni mutants. Inoculated birds were then orally challenged with the parental strain. Inoculation with the C. jejuni mutants did not provide protection from subsequent challenge with the wild-type strain. In addition, neither the C. jejuni parental nor the mutant strains caused any apparent morbidity or mortality of the chicks. We conclude that mutations in genes cadF, dnaJ, pldA, and ciaB impair the ability of C. jejuni to colonize the cecum, that chicks tolerate massive inoculation with these mutant strains, and that such inoculations do not provide biologically significant protection against colonization by the parental strain.
Cushing syndrome related to leukemic infiltration of the central nervous system

Abstract Background: Cushing syndrome (CS) due to central nervous system (CNS) infiltration of hematological malignancy is a rare finding. Case: A 6.5-year-old boy with B cell acute lymphoblastic leukemia (ALL) came with excessive weight gain, headache, and irritability over last 2 months. CNS was not involved at diagnosis of ALL. On examination, the child had central obesity, moon facies, and buffalo hump. His height was at 3rd–25th percentile, weight was at >97th percentile, and blood pressure was >99th percentile. Serum cortisol was high in morning (25 μg/dL), at 12 a.m. (19.3 μg/dL) and remained elevated (7.5 μg/dL) after overnight dexamethasone test. Examination of cerebrospinal fluid (CSF) revealed blast cells suggestive of CNS relapse. Our second case was a 2.5-year-old girl with precursor B cell ALL, came with complaints of excessive weight gain, and increased appetite over last 3 months. On examination, the child had Cushingoid facies with trunkal obesity. Blood pressure was normal. Serum cortisol at 8 a.m. (40.4 μg/dL), midnight (13.8 μg/dL), and after dexamethasone suppression test (22 μg/dL) was high. CSF examination showed blast cells. We diagnosed both cases with adrenocorticotropic hormone-dependent CS due to CNS relapse based on the above findings. Conclusion: We have reported two cases of CS due to CNS relapse of ALL. CS is a very rare manifestation of CNS relapse in patients with leukemia, and the exact pathogenesis is not clear.
The Role of Counterparty Risk and Asymmetric Information in the Interbank Market

We study the effect of counterparty risk on the ability of Italian banks to access the foreign unsecured interbank market during the sovereign debt crisis in the second half of 2011. With the onset of the crisis, interest rates in the Italian interbank market soared and foreign lending decreased significantly. To isolate the effect of the rise in counterparty risk, we compare the funding of Italian banks with that of foreign banks’ branches and subsidiaries in Italy, which were presumably unaffected by the sovereign crisis insofar as they could count on the actual or potential support of their parent bank. We find that the rise in counterparty risk substantially decreased the probability of obtaining funds from foreign banks. When the analysis is restricted to Italian and foreign banks with relatively comparable asset compositions, the result holds. In addition, where safer banks or more stable lending relationships are involved the effect is attenuated. JEL Classification: G21, G28, C23, C24
The Impact of Intellectual capital on Financial Reporting Quality: An Evidence from Tehran Stock Exchange

This study investigates the effect of different intellectual capital components on the financial reporting quality. In order to conduct this study, a sample including 184 accepted companies in Tehran Stock Exchange that work in deference industries between 2004 and 2009 have been selected. The methodology of the present study is co relational research and has an applied purpose. Co relational analysis and multiple linear regressions are the statistical methods are used in this study. The results from hypothesis testing demonstrated among the different components of intellectual capital, two components of capital employed efficiency and human capital efficiency have significant positive effect on the dependent variable of financial reporting quality and structural capital efficiency has a significant negative effect on the financial reporting quality. Among these three components of intellectual capital, the effect of human capital efficiency on the financial reporting quality is stronger with than the other two factors.
Greater disorderliness of ACTH and cortisol release accompanies pituitary-dependent Cushing's disease.

We investigated the episodicity of 24-h ACTH and cortisol secretory profiles in 16 patients with Cushing's disease and 25 healthy matched controls, with a recently introduced scale- and model-independent regularity statistic, approximate entropy (ApEn). The mean (+/-S.E.M.) ApEn value for plasma ACTH concentrations in Cushing's disease was 1.3817 +/- 0.033, and in controls 0.8394 +/- 0.049 (P < 10(-10)); for plasma cortisol concentrations the values were 1.4575 +/- 0.052 and 0.8637 +/- 0.020 respectively (P < 10(-10)), implying greater irregularity of release for both hormones in Cushing's subjects. The calculated sensitivity and specificity of ApEn for ACTH profiles were 94% and 100% respectively. For cortisol the sensitivity and specificity were both 100%. ApEn was not correlated with sex, age, or the total 24-h secretion rate of ACTH and cortisol in patients and controls. The increased ApEn in patients with Cushing's disease points to an increased disorderliness of ACTH and cortisol secretion compared with healthy controls. In conjunction with the available literature, we hypothesize more generally that autonomous endocrine tumors may be typified by reduced regularity, orderliness, or synchrony of the time structure of hormone release.
DISENTANGLING PRECOPULATORY AND POSTCOPULATORY SEXUAL SELECTION IN POLYANDROUS SPECIES

Sexual selection operates on a sequence of events, from mating to offspring production. Which stages in this sequence undergo stronger selection, especially the relative importance of pre‐ versus postcopulatory processes, are intensely debated issues. Unequal siring success among mates of polyandrous females is classically taken as evidence for a large contribution of postcopulatory processes to the variance in male reproductive success (var(RSm)). However, paternity skews also depend on the timing and number of copulations, a source of variation that should be considered precopulatory rather than postcopulatory. We develop a method for decomposing var(RSm) accounting for copulatory activity and apply it to experimental mating groups of the snail Physa acuta. In our experiment, 40% of var(RSm) emerges at the precopulatory stage, only half of which depends on variation in mating success (number of partners). Ignoring copulation characteristics can therefore lead to severe underestimation of precopulatory sexual selection. Moreover, although only 36% of var(RSm) arises at the postcopulatory stage, this is when sexual selection on body weight mostly occurs. Finally, trade‐offs were detected between different components of precopulatory success, whereas pre‐ and postcopulatory success appear independent. Our study opens the way to a detailed quantitative understanding of sexual selection in polyandrous species.
Business pluralism of electronic prescriptions: state of development in Europe and the USA

In this paper, we analyse the current state of the development of electronic prescriptions in Europe and the USA. These two places have different approaches to the healthcare sector, since in the former one national social insurance usually provides treatment for all of the people (most often only with friction from total costs), but in the latter one the healthcare sector is under free market forces. As our analysis shows in this paper, electronic prescriptions in both of the places have developed in recent years quite favourably, but this development has not produced consistent results, whether electronic prescriptions should be provided by for-profit companies or should they be under strict control of governmental authorities. We base this finding in two empirical observations: (1) in Europe saving potential from electronic prescriptions is estimated to be high, and contains many abstract national economy accounts and (2) leading US companies (providing electronic prescription services) have went been able to increase their revenues significantly, but still their profitability is questionable. We argue that the situation of electronic prescriptions is similar with airline or credit card industry. Both of these are vital for international and local economies, but the business models have developed well after the initial idea.
Extending OAuth2 to Join Local Services into a Federative SOA

New approaches to teaching and research require machine readable interfaces as provided by service oriented architectures. Many scenarios in teaching as well as in research demand cooperation between members of universities. Identity federations and federated applications provide some means for collaboration. Current federation services for single sign on however are not compatible with common applications arising from service oriented architectures. The OAuth2 workflow allows personalized access to service oriented architectures for applications but lacks a definition for federated deployment. The presented extensions are based on the current implementation of OAuth2 They allow establishing a federation of OAuth2 token services that builds on top of the existing federated infrastructures in higher education.