Miracle-dz/UniFAR-FTUs huggingface dataset:
Spoofing detection with DNN and one-class SVM for the ASVspoof 2015 challenge

Speaker verification systems have achieved great performance in recent times. However, we usually measure performance on a ideal scenarios with naive impostors that do not modify their voices to impersonate the target speakers. The fact of impersonating a legitimate user is known as spoofing attack. Recent works show the vulnerability of current speaker verification technology to several types of attacks. Most of these works use non-public databases and different performance measures, which makes difficult to compare approaches. The spoofing challenge (ASVspoof 2015) tries to overcome this problem by proposing a common evaluation framework. This paper describes our submission to the challenge. We proposed to use spectral log-filter-bank and relative phase shift features as input to classifiers based on deep neural networks (DNN). The first of our classifiers used DNN posteriors to decide if the trial is spoof or non-spoof. The second used a bottleneck feature from the DNN as input to a one-class SVM. The one-class SVM models the distribution of legitimate speech, not needing spoofing data for training. We fused the score of the different classifiers to produce our final submission. Our system attained very competitive results with EER<0.05% in 9 out of 10 spoofing types.
Traditional Chinese Corporations: Beyond Kinship

Emphasis on descent and kinship in analysis of traditional Chinese corporations, a legacy of structural-functional theory, mistakes the analyst's theoretical categories for native culture. In this paper, the author attempts to sort out some of the resulting conceptual muddles, and he proposes a more rigorous analytical framework for discussing the range of organizational variation in traditional Chinese corporations. Analysis of ten representative cases from Ta-ch'i, Taiwan, reveals greater flexibility of corporate form and function than structural-functional theories would predict. Close attention to the cases also reveals the absence of any compelling reason to treat the “Chinese lineage” as analytically or culturally distinct from the entire range of Chinese formal associations (hui). To understand what is uniquely Chinese in Chinese corporations, past emphasis on differences in formal group-membership requirements must be complemented by attention to the cultural values and norms of operation that transcend such differences.
HPV and Chlamydia trachomatis co‐detection in young asymptomatic women from high incidence area for cervical cancer

Chlamydia trachomatis causing chronic inflammatory diseases has investigated as possible human papillomavirus (HPV) cofactor in cervical cancer. The aim of this study is to evaluate the prevalence of Chlamydia trachomatis and HPV co‐infection in different cohorts of asymptomatic women from a Northern Italy area at high incidence for cervical cancer. Cervical samples from 441 females were collected from Cervical Cancer Screening Program, Sexually Transmitted Infectious and Assisted Reproductive Technology centres. HPV and Chlamydia trachomatis were detected simultaneously and genotyped using a highly sensitive bead based assay. The overall prevalence of Chlamydia trachomatis was estimated 9.7%, in contrast with the reported national data of 2.3%, and co‐infection with HPV was diagnosed in the 17% of the samples. In females ≤ 25 years of age, the infection reached a peak of 22% and co‐infection with HPV of 45.8% (P < 0.001). Of note, in young females diagnosed with low grade cervical lesions, no significant difference between Chlamydia trachomatis and HPV distribution was observed, while differently, HPV co‐infection was found significantly associated to the presence of intraepithelial lesions when compared to older females (20% vs. 1%; P < 0.001). In this study, the use of a high sensitive molecular technique exhibited higher analytical sensitivity than the referred assays for the diagnosis of Chlamydia trachomatis and HPV co‐infection in asymptomatic females, leading to reduction of the potential to identify incorrectly the infection status. An active screening for timely treatment of Chlamydia trachomatis infection is suggested in young females to evaluate a possible decrease in incidence of pre‐cancer intraepithelial lesions. J. Med. Virol. 86:1920–1925, 2014. © 2014 Wiley Periodicals, Inc.
Cellular responses to hypoxia in the pulmonary circulation

Abstract Welsh, David J., and Andrew J. Peacock. Cellular responses to hypoxia in the pulmonary circulation. High Alt Med Biol 14:111–116, 2013. —Hypoxia can be defined as a reduction in available oxygen, whether in a whole organism or in a tissue or cell. It is a real life cause of pulmonary hypertension in humans both in terms of patients with chronic hypoxic lung disease and people living at high altitude. The effect of hypoxia on the pulmonary vasculature can be described in two ways; Hypoxic pulmonary vasoconstriction (HPV) (resulting from smooth muscle cell contraction) and pulmonary vascular remodelling (PVR) (resulting from pulmonary vascular cell proliferation). The pulmonary artery is made up of three resident cell types, the endothelial (intima), smooth muscle (media) and fibroblast (adventitia) cells. This review will examine the effects of hypoxia on the cells of the pulmonary vasculature and give an insight into the possible underlying mechanisms.
Induction of pRb Degradation by the Human Papillomavirus Type 16 E7 Protein Is Essential To Efficiently Overcome p16INK4a-Imposed G1 Cell Cycle Arrest

ABSTRACT It has previously been shown that the E7 protein from the cutaneous human papillomavirus type 1 (HPV1), which is associated with benign skin lesions, binds the product of the tumor suppressor gene retinoblastoma (pRb) with an efficiency similar to that of the E7 protein from the oncogenic HPV type 16. Despite this ability, HPV1 E7 does not display any activity in transforming primary cells. In addition, the two viral proteins differ in their mechanisms of targeting pRb. HPV16 E7 promotes pRb destabilization, while cells expressing HPV1 E7 do not show any decrease in pRb levels. In this study, we show that HPV1 E7, in contrast to HPV16 E7, has only a weak activity to neutralize the effect of cyclin-dependent kinase inhibitor p16INK4a. By generation of HPV1/16 E7 chimeric proteins, we have identified a central motif in the two E7 proteins, which determines their different abilities to overcome the p16INK4a-mediated cell cycle arrest. This motif is located downstream of the pRb-binding domain and comprises only three amino acids in HPV16 E7. Swapping this central motif in the two viral proteins causes an exchange of their activities involved in circumventing the inhibitory function of p16INK4a. Most importantly, our data show that the efficiency of the E7 proteins in neutralizing the inhibitory effect of p16INK4a correlates with their ability to promote pRb degradation.
Using Biacore to Measure the Binding Kinetics of an Antibody‐Antigen Interaction

The optical phenomenon of surface plasmon resonance (SPR) used by Biacore systems enables the detection and measurement of protein‐protein interactions in real time, without the use of labels. In this unit, the application of Biacore technology to measure a protein‐protein interaction is described using an antibody and its antigen as an example. The affinity of the antibody for its antigen is determined by measuring the binding kinetics of the interaction. The protocols are divided into three major steps that are required for measuring binding kinetics using Biacore: (1) surface preparation, (2) assay development, and (3) kinetic analysis.
PDR/fingerprinting fusion indoor location tracking using RSS recovery and clustering

Due to the received signal strength (RSS) variation, WiFi indoor positioning techniques using RSS have difficulties to provide good location estimates. To mitigate the effect of the RSS variation, this paper presents a Kalman filter-based positioning algorithm that is combined with pedestrian dead reckoning and RSS-based fingerprinting positioning. The RSS recovery and clustering methods are also introduced to enhance the accuracy of the fingerprinting positioning. Unlike other existing algorithms, the proposed algorithm estimates biases accumulated in RSS measurements based on the recursive least square estimation and removes them from the measurements. Reference points are effectively selected with clustering using the recovered RSS measurements. Hence, a more accurate location estimate can be obtained in the existence of the RSS variation. The proposed algorithm is implemented into an Android-based smartphone for test.
Design and modeling of a passive wireless SAW transponder

In this work, a finite element analysis was employed to analyze the second order effects of a passive surface acoustic wave (SAW) transponder. The second order effects, which occur due to the electrode perturbation and wave reflection, were analyzed using a two-dimensional finite element analysis method. A 31-bit Pseudo Random (PN) code sequence was implemented to demonstrate the second order effects on different configurations of the SAW transponder. Analyses of the response has shown that the second order effects on the impulse response become increasingly significant as the device operated in a high frequency (915 Mz) with high data rate (31bit). These quantitative analyses of the second order effects provide insights for designing high performance SAW transponders for high frequency applications. The result also shows that the output signal can be enhanced by increasing the number of input interdigital transducers (IDT).
1′-Acetoxychavicol Acetate Inhibits RANKL–Induced Osteoclastic Differentiation of RAW 264.7 Monocytic Cells by Suppressing Nuclear Factor-κB Activation

Osteoclastogenesis is commonly associated with various age-related diseases, including cancer. A member of the tumor necrosis factor superfamily, receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL), has been shown to play a critical role in osteoclast formation and bone resorption. Thus, agents that suppress RANKL signaling have a potential to suppress bone loss. In this report, we investigated the effect of 1′-acetoxychavicol acetate (ACA), a component of Alpina galanga, on RANKL signaling and consequent osteoclastogenesis in RAW 264.7 cells, a murine monocytic cell line. Treatment of these cells with RANKL activated NF-κB, and coexposure of the cells to ACA completely suppressed RANKL-induced NF-κB activation in a time- and concentration-dependent manner. The suppression of NF-κB by ACA was mediated through suppression of RANKL-induced activation of IκBα kinase, IκBα phosphorylation, and IκBα degradation. Furthermore, incubation of monocytic cells with RANKL induced osteoclastogenesis, and ACA suppressed it. Inhibition of osteoclastogenesis was maximal when cells were simultaneously exposed to ACA and RANKL and minimum when ACA was added 2 days after RANKL. ACA also inhibited the osteoclastogenesis induced by human breast cancer MCF-7 cells, multiple myeloma MM1 cells, and head and neck squamous cell carcinoma LICR-LON-HN5 cells. These results indicate that ACA is an effective blocker of RANKL-induced NF-κB activation and of osteoclastogenesis induced by RANKL and tumor cells, suggesting its potential as a therapeutic agent for osteoporosis and cancer-associated bone loss. (Mol Cancer Res 2006;4(4):275–81)
Experimental investigation of the LLC-type parallel resonant converter

Based on the theoretical analysis of R. Liu et al. (see Proc. High Freq. Power Conv. Conf., p.486-96 (1989)), a complete set of design curves for the LLC-type parallel resonant converter is derived. Using these curves, a design procedure for the converter operating in the continuous conduction mode and with natural commutation is formulated. As an example, a 150 W, 150 kHz, multioutput LLC-type parallel resonant converter power supply was designed and tested. Various test waveforms for the output load variation from 10% load to full load and the input voltage variation from 90 VAC to 130 VAC line voltages are presented. The experimental results and the theoretical values are in good agreement. <<ETX>>
Variable impedance matching network based on varactor diodes

in this paper a varactor-based variable impedance matching network intended to be integrated in an automatic impedance matching system is designed. The operating frequency is fixed at 2.4 GHz, suitable for Industrial, Scientific and Medical applications. The proposed design features broad impedance coverage with a low reflection loss. The simulation results demonstrated the efficiency of the proposed design for narrow band applications.
A web-based toolkit for remote direct manipulation interaction with public displays via smartphones

Public displays are becoming increasingly interactive but we still need better programming tools that take the burden of adding interaction features to display applications. In this paper, we present a toolkit for web-based, remote, direct manipulation interaction with public display applications. Our toolkit provides high-level controls such as joystick, text input, and multi-touch cursor events, allowing programmers to focus on the interaction experience of the application.
Using air photos to interpret quality of Marbled Murrelet nesting habitat in south coastal British Columbia

Reliable habitat assessment methods are needed to ensure the adequate management of Marbled Murrelet (Brachyramphus marmoratus) habitat in British Columbia. In two south coastal study regions, the Sunshine Coast and Clayoquot Sound, we evaluated the effectiveness of a qualitative habitat classification that uses air photo-interpreted forest structural characteristics for identifying and ranking habitat quality. Using a sample of 118 nest sites and 157 random sites within forests greater than 140 years old, we found that murrelets selected nest patches non-randomly with respect to forest characteristics. While selectivity varied between study regions, generally nest patches had taller and larger trees, exhibited more complex forest structure, and were located at lower meso-slope positions near large gaps or nearby edges. In addition, these patches were more often ranked higher in terms of habitat quality. However, we found that probable breeding success was greater in habitats classified as lower quality. Thus, further research is needed to understand our findings relative to other influences on breeding productivity, such as predators and hierarchal habitat selection. In summary, while our study supports the use of the current air photo habitat classification standards to improve identification and selection of murrelet nesting habitat for management, some modifications to these standards may be needed.
Stephen Biesty's Incredible Explosions

Thank you for downloading stephen biestys incredible explosions. Maybe you have knowledge that, people have search hundreds times for their chosen books like this stephen biestys incredible explosions, but end up in harmful downloads. Rather than reading a good book with a cup of tea in the afternoon, instead they cope with some harmful virus inside their computer. stephen biestys incredible explosions is available in our book collection an online access to it is set as public so you can download it instantly. Our digital library spans in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the stephen biestys incredible explosions is universally compatible with any devices to read.
Bandgap separation and optical switching in nonlinear chiral photonic crystal with layered structure

The chiral photonic crystal (PC) with layered structure is investigated by using the finite-difference time-domain method. The bandgap separation for right-hand/left-hand circularly polarized light in chiral PC is demonstrated by comparing to the achiral case. The effect of layer number and the optical nonlinearity on bandgap structure is analyzed. Optical switching with the help of the change in bandgap structure is discussed. A novel scheme of an all-optical switch based on sideband improved by apodization is proposed
Analytical inverse kinematic solution using the D-H method for a 6-DOF robot

This paper proposes an analytical approach to solve inverse kinematics of a 6-DOF robot. The robot discussed here is designed with 6R configuration. The D-H model of the six-axis robot is built. The forward analytical solution is deduced using the D-H method. Then, analysis of inverse kinematics for the robot is presented. And finally, the validity of the inverse kinematic equations is verified. Forward kinematic equations and inverse kinematic equations are suitable for all kinds of robots with configuration similar to those of the robot in this paper.
Mapping the world's topography using radar interferometry: the TOPSAT mission

Global-scale topographic data are of fundamental importance to many Earth science studies, and obtaining these data is a priority for the Earth science community. Several groups have considered the requirements for such a data set, and a consensus assessment is that many critical studies would be enabled by the availability of a digital global topographic model with accuracies of 2 and 30 m in the vertical and horizontal directions, respectively. Radar interferometric techniques have been used to produce digital elevation models at these accuracies and are technologically feasible as the centerpiece of a spaceborne satellite mission designed to map the world's land masses, which we denote TOPSAT. A radar interferometer is formed by combining the radar echoes received at a pair of antennas displaced across-track, and specialized data processing results in the elevation data. Two alternative implementations, one using a 2 cm-/spl lambda/ radar, and one using a 24 cm-/spl lambda/ radar, are technologically feasible. The former requires an interferometer baseline length of about 15 m to achieve the required accuracy, and this could be built on a single spacecraft with a long extendible boom. The latter necessitates a kilometers long baseline, and would thus be best implemented using two spacecraft flying in formation. Measurement errors are dominated by phase noise, due largely to signal-to-noise ratio considerations, and attitude errors in determining the baseline orientation. For the 2-m accuracy required by TOPSAT, the orientation must be known to 1 arc-second. For the single-spacecraft approach, where attitude would be determined by star tracking systems, this performance is just beyond the several arc-second range of existing instruments. For the dual-spacecraft systems, though, differential global positioning satellite measurements possess sufficient accuracy. Studies indicate that similar performance can be realized with either system. >
The expert approach: a case study

This article presents an experiment under the EC IST 34488 eXPERT project in Rila Solutions (a Bulgarian software company). The approach is a systematic combination of Extreme Programming (XP) and Personal Software Process (PSP). The Rila Solutions context of applying eXPERT approach is presented. The advantages of applying the eXPERT approach, as well as the lessons learned, are outlined.
The production of placental protein 14 and interleukin 6 by human endometrial cells in culture.

Epithelial and stromal cells prepared from endometrium taken at different times in the menstrual cycle were grown in primary culture and the production of placental protein 14 (PP14) and interleukin-6 (IL6) measured. Only the epithelial cells produced PP14. Epithelial cells from endometrium in the late secretory phase produced significantly greater amounts of PP14 (42 +/- 5.8 ng/24 h) compared with that produced by cells from early secretory and proliferative endometrium (16 +/- 1.7 and 11 +/- 1.9 ng/24 h respectively). PP14 production by cells from endometrium at all stages in the cycle was increased by progesterone, or progesterone and oestradiol together, while oestradiol alone had no effect on PP14 production. The greatest stimulation was seen during the early secretory phase when stimulated levels of PP14 reached those obtained during the late secretory phase. IL6 production by epithelial cells also varied depending on the phase of the menstrual cycle. More IL6 was produced by the cells prepared from the endometrium in the proliferative phase (10.9 +/- 0.56 ng/24 h) compared with that produced by cells from early and late secretory endometrium (2.5 +/- 0.19 and 1.45 +/- 0.09 ng/24 h respectively). Addition of steroids to the media stimulated the production of IL6 by cells from proliferative and early secretory endometrium but decreased IL6 production from cells in the late secretory phase. IL6 was also produced by stromal cells but could only be detected in supernatants of cells prepared from late secretory endometrium, and the amounts produced (0.8 +/- 0.09 ng/24 h) were less than that produced by epithelial cells. (ABSTRACT TRUNCATED AT 250 WORDS)
ART: a next-generation sequencing read simulator

UNLABELLED ART is a set of simulation tools that generate synthetic next-generation sequencing reads. This functionality is essential for testing and benchmarking tools for next-generation sequencing data analysis including read alignment, de novo assembly and genetic variation discovery. ART generates simulated sequencing reads by emulating the sequencing process with built-in, technology-specific read error models and base quality value profiles parameterized empirically in large sequencing datasets. We currently support all three major commercial next-generation sequencing platforms: Roche's 454, Illumina's Solexa and Applied Biosystems' SOLiD. ART also allows the flexibility to use customized read error model parameters and quality profiles. AVAILABILITY Both source and binary software packages are available at http://www.niehs. nih.gov/research/resources/software/art.