Miracle-dz/UniFAR-FTUs huggingface dataset:
T suppressor cell growth factor and anti-CD3 antibodies stimulate reciprocal subsets of T lymphocytes

Because of the central role of IL-2 in clonal expansion of T cells, we have postulated that lymphocyte subpopulations with opposing regulatory functions might be independently regulated by differential requirements for expression of cell-surface IL-2-R. Purified CD4+ and CD8+ cells proliferated in an IL-2-dependent manner to crosslinked anti-T cell receptor antibodies (anti-CD3-Seph). Similarly, both CD4+ and CD8+ cells became IL-2 responsive after incubation in T suppressor cell growth factor (TsGF), a newly described approximately 8,000 Mr product of activated CD4+ cells. In support of our hypothesis, however, we observed that subpopulations of CD4+ and CD8+ cells, possessing distinct cell-surface antigens, showed differential responses to these stimuli. Those cells of suppressor-inducer or suppressor-effector phenotype failed to proliferate when cultured in anti-CD3-Seph plus IL- 2, but did proliferate in an IL-2-dependent manner to TsGF. Furthermore, the suppressor-effector population was unresponsive to TsGF plus IL-2 when cocultured in anti-CD3-Seph, suggesting that functionally induced Ts may be refractory to growth stimuli. Conversely, cells with helper-inducer or cytolytic phenotype proliferated when incubated in anti-CD3-Seph and IL-2, while remaining essentially unresponsive to TsGF and IL-2. The results could not be explained by differences in the level of CD3 expression by the T cell subsets. Thus, cells within the helper and suppressor lineages appear to have distinct and reciprocal patterns for the induction of IL-2 responsiveness.
An empirical study on the existence of bubble in Chinese stock market: Based on TGARCH model

This paper collected the closing price index of Shanghai Stock Exchange from Jan. 3, 2005 to Mar. 29, 2010 as the initial data for the study, and adopted TGARCH model to analyze the volatility of financial risk within China Mainland stock market through these five years around the international financial crisis, and discussed the existence of bubble in Chinese Mainland stock market.
A lagrangian relaxation approach for a machinery location problem in forest harvesting

The correct location of harvesting machinery is an important problem for the timber industry, as these are expensive pieces of equipment. Also, access roads need to be constructed within a season of harvesting. In this paper, we present the modelling of this problem as a mixed integer linear model which, without any special technique, is very difficult to solve. Strengthening of the original linear programming formulation, and a Lagrangian Relaxation algorithm are developed to improve the solution process. We show test results in a real industry problem.
Tendinitis : An In Vivo Electromyography Study Rehabilitation Exercise Progression for the Gluteus Medius Muscle With Consideration for Iliopsoas

http://ajs.sagepub. com/content/39/8/1777 The online version of this article can be found at: DOI: 10.1177/0363546511406848 2011 39: 1777 originally published online May 12, 2011 Am J Sports Med Marc J. Philippon, Michael J. Decker, J. Erik Giphart, Michael R. Torry, Michael S. Wahoff and Robert F. LaPrade Tendinitis : An In Vivo Electromyography Study Rehabilitation Exercise Progression for the Gluteus Medius Muscle With Consideration for Iliopsoas
Correlation between epidermal growth factor receptor tyrosine kinase inhibitor efficacy and circulating tumor cell levels in patients with advanced non-small cell lung cancer

Objective The aim of this study was to investigate the correlation between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and circulating tumor cell (CTC) levels in patients with advanced non-small cell lung cancer (NSCLC). The efficacy of EGFR-TKIs in reducing CTC counts in patients with advanced NSCLC was studied. Patients and methods A total of 66 patients with advanced NSCLC were enrolled and divided into two groups (those with high CTC counts and those with low CTC counts) based on the patients’ median CTC counts. All the patients were treated with an EGFR-TKI, and the treatment efficacy and prognoses were compared. Results The treatment efficacies were 53.3% (16/30) and 27.8% (10/36) for the low CTC group and high CTC group, respectively, and this difference was statistically significant (P<0.05). The median overall survival was 22.8 months (95% confidence interval [CI]: 18.9–26.8 months) for the low CTC group and 18.3 months (95% CI: 2.9–8.2 months) for the high CTC group. The median progression-free survival was 11.5 months (95% CI: 8.1–15 months) and 5.6 months (95% CI: 2.9–8.2 months) for the low and high CTC groups, respectively, and the difference was statistically significant (P<0.05). Conclusion The CTC count can be used as an index for predicting the EGFR-TKI effect on patients with advanced NSCLC. Efficacy and prognosis of EGFR-TKI treatment and CTC count were considered important, and the CTC count could be used to predict the efficacy of EGFR-TKI treatment and prognosis of advanced NSCLC. The change in CTC expression levels can be used as an index for evaluating the prognosis of patients with advanced NSCLC.
Simultaneous wireless information and power transfer in OFDM systems based on subcarrier allocation

Energy harvesting (EH) is a prominent method to prolong the operation time of energy-constrained wireless networks. Integrating EH into wireless communications to support simultaneous wireless information and power transfer (SWIPT) allows the spectrum to be used for both purposes without compromising the quality of service (QoS). In this paper, we propose a subcarrier allocation based SWIPT scheme in orthogonal frequency division multiplexing (OFDM) systems. Specifically, the received OFDM subcarriers are partitioned into two groups. A part of the received subcarriers are allocated to form one group which are used for information decoding (ID), and the remained subcarriers form another group, which are used for energy harvesting. Thus, no splitter is needed at the receiver. We study the optimal subcarrier allocation such that the harvested energy is maximized with the ID constraint. By using the Lagrangian method, we develop efficient algorithm to solve the optimization problem.
Antiurolithiatic activity of Abelmoschus moschatus seed extracts against zinc disc implantation-induced urolithiasis in rats

Background: The commonly used techniques for removing renal calculi are associated with the risk of acute renal injury and increase in stone recurrence which indicates an urgent need for alternate therapy.Objectives: The aim was to evaluate the antiurolithiatic activity of Abelmoschus moschatus seed extracts in rats.Materials and Methods: Urolithiasis was induced by surgical implantations of zinc disc in the urinary bladders of rats. Upon postsurgical recovery, different doses of chloroform (CAM) and methanolic (MAM) extracts of A. moschatus seeds (viz., 100, 200 and 400 mg/kg body weight) were administered to disc implanted rats for the period of 7 days by the oral route. Antiurolithiatic activity was evaluated by measuring various dimensions of stones and estimating levels of various biomarkers in serum and urine samples.Results: A significant decrease in urinary output was observed in disc implanted animals, which was prevented by the treatment with extracts. Supplementation with extracts caused significant improvement in glomerular filtration rate and urinary total protein excretion. The elevated levels of serum creatinine, uric acid, and blood urea nitrogen were also prevented by the extracts. The extracts significantly reduced deposition of calculi deposition around the implanted disc. This antiurolithiatic potential is observed at all doses (100, 200, and 400 mg/kg) of MAM, whereas only higher dose (400 mg/kg) of CAM showed significant antiurolithiatic potential.Conclusion: The extracts of A. moschatus seeds possessed significant antiurolithiatic activity. The possible mechanism underlying this effect is mediated collectively through diuretic, antioxidant, and free-radical scavenging effects of the plant.
Mitogen-activated protein kinase phosphatase 2 regulates histone H3 phosphorylation via interaction with vaccinia-related kinase 1

Vaccinia-related kinase 1 (VRK1) is a histone kinase that phosphorylates histone H3 at Thr-3 and Ser-10. This study shows that mitogen-activated protein kinase phosphatase 2 regulates this phosphorylation negatively via interaction with VRK1, regardless of VRK1’s phosphatase activity.
A User Study Comparing 3D Modeling with Silhouettes and Google SketchUp

We recently introduced 3D Modeling with Silhouettes [1], a new sketch-based modeling approach in which models are interactively designed by drawing their 2D silhouettes from different views. The core idea behind our approach is to limit the input to 2D silhouettes, removing the need to explicitly create or position 3D elements. Arbitrarily complex models can be constructed by assembling them out of parts defined by their silhouettes, which can be combined using CSG operations. In this technical report, we describe a user study comparing 3D Modeling with Silhouettes and Google SkechUp [2]. We chose to compare to SketchUp as it is also intended for novice users, and also aimed at the creation of man-made objects.
Iterative soft-decision directed timing estimation for turbo receivers

The current paper addresses the issue of estimating the sampling instant in turbo receivers. More specifically, we focus on a transmitter made of bit interleaved coded modulation. The proposed synchronizer is based on the maximization of an approximation of the timing log-likelihood function. In particular, we approximate the a priori probabilities in the log-likelihood function from the bit a posteriori probabilities provided by the turbo receiver. The maximization is performed by means of a NewtonRaphson method based on an early-late implementation. Performance of the proposed synchronizer is illustrated by simulation results. The mean and the variance of the estimator as well as the bit error rate reached by the synchronized system are reported. I. I NTRODUCTION SINCE the discovery of turbo codes by Berrou and Glavieux [1], the so-called turbo principle has been extended to a great number of operations to be performed by a receiver: joint decoding and demodulation, joint decoding and equalization. In addition to detection and decoding, a receiver has also to estimate a number of synchronization parameters in order to work properly. In particular, timing recovery is an essential operation in digital transmission systems in order to obtain reliable decision variables [2]. Most of the classical timing synchronizers are derived from the maximum likelihood (ML) criterion and usually work in data-aided (DA), decision-directed (DD) or non data-aided (NDA) modes. However, since turbo systems operate at low SNR values, classical estimators fail to provide good estimates of the synchronization parameters. Moreover, in turbo receivers, soft information on bits or symbols is available at the decoder output. It would therefore be interesting to try using this soft information in order to help the synchronizer. The idea of using soft information to estimate parameters has already been applied in a number of contributions. References [3] and [4], for instance, propose to combine soft decisiondirected carrier phase estimation with turbo decoding. In [5] a carrier phase recovery method embedded in a maximum a posteriori (MAP) decoder and exploiting the extrinsic information generated at each iteration is reported. Papers [6] and [7] present a unifying framework for ML synchronization in turbo systems. In particular, it is shown that the approach presented in [3] is actually a particular instance of the ExpectationMaximization (EM) algorithm [8]. This work has been supported by the Interuniversity Attraction Poles Programme Belgium State Federal Office for Scientific, Technical and Cultural Affairs. Encoder Interleaver Mapper bits Channel Waveform r(t) ak
PWSSec: Process for Web Services Security

In the last few years, the field of Web services (WS) security has evolved rapidly producing an impressive number of WS-based security standards. This fact has caused that organizations are still reticent about adopting technologies based on this paradigm due to the learning curve necessary to integrate security into their practical deployments. In this paper, we present PWSSec (process for Web services security) as a process that enables the integration of a set of specific stages into the traditional phases of WS-based systems development providing them with security. PWSSec is composed of three stages, WSSecReq (Web services security requirements), WSSecArch (Web services security architecture) and WSSecTech (Web services security technologies) that allow the specification of WS-specific security requirements, the definition of the WS-based security architecture and the identification of the security standards that the security architecture must deploy, respectively
Designing cost-efficient wireless sensor/actuator networks for building control systems

A modern Building Automation System (BAS) aims to enhance the functionality of interactive control strategies leading towards energy efficiency and enhanced user comfort. Typically, it is cheaper to embed the BAS within a Wireless Sensor/Actuator Network (WSAN) rather than rewire legacy. However, the cost of a WSAN deployment is a critical factor for the new buildings. In this context, we develop a co-design approach for assessing the cost of a WSAN deployment while achieving particular control performance. We apply the developed co-design strategy to a distributed control for building lighting systems. We empirically compare our developed system for building lighting control strategy with a standard PI control method to demonstrate an average of 45% reduction in energy use while maintaining the user comfort and 23% saving in the network cost.
Ecological genomics of local adaptation in Cornus florida L. by genotyping by sequencing

Abstract Discovering local adaptation, its genetic underpinnings, and environmental drivers is important for conserving forest species. Ecological genomic approaches coupled with next‐generation sequencing are useful means to detect local adaptation and uncover its underlying genetic basis in nonmodel species. We report results from a study on flowering dogwood trees (Cornus florida L.) using genotyping by sequencing (GBS). This species is ecologically important to eastern US forests but is severely threatened by fungal diseases. We analyzed subpopulations in divergent ecological habitats within North Carolina to uncover loci under local selection and associated with environmental–functional traits or disease infection. At this scale, we tested the effect of incorporating additional sequencing before scaling for a broader examination of the entire range. To test for biases of GBS, we sequenced two similarly sampled libraries independently from six populations of three ecological habitats. We obtained environmental–functional traits for each subpopulation to identify associations with genotypes via latent factor mixed modeling (LFMM) and gradient forests analysis. To test whether heterogeneity of abiotic pressures resulted in genetic differentiation indicative of local adaptation, we evaluated F st per locus while accounting for genetic differentiation between coastal subpopulations and Piedmont‐Mountain subpopulations. Of the 54 candidate loci with sufficient evidence of being under selection among both libraries, 28–39 were Arlequin–BayeScan F st outliers. For LFMM, 45 candidates were associated with climate (of 54), 30 were associated with soil properties, and four were associated with plant health. Reanalysis of combined libraries showed that 42 candidate loci still showed evidence of being under selection. We conclude environment‐driven selection on specific loci has resulted in local adaptation in response to potassium deficiencies, temperature, precipitation, and (to a marginal extent) disease. High allele turnover along ecological gradients further supports the adaptive significance of loci speculated to be under selection.
Performance analysis of adaptive interaction control laws for rehabilitation robotics

In this work a comparative analysis is carried out of adaptive compliance control laws developed by the authors for biomedical applications of human-robot interaction. They are the self-regulated compliance control in the joint space in [1], the coactivation-based compliance control in the joint space in [2] and the torque-dependent compliance control in the joint space in [3]. The control laws try to overcome limitations of the traditional interaction control by making the control gains adaptable to the interacting environment. To this purpose, inspiration from biological motor control is taken, with particular attention to the mechanisms of visco-elastic regulation of the human arm. A specific performance metrics is developed which allows measuring control performance especially in the interaction with the environment through the analysis of impact dynamics. Experimental trials of motion in the free space and impact against an obstacle are arranged with the MIT-Manus robot available in our lab, and a comparison with state-of-the-art traditional compliance controls is carried out.
Sox10 Is an Active Nucleocytoplasmic Shuttle Protein, and Shuttling Is Crucial for Sox10-Mediated Transactivation

ABSTRACT Sox10 belongs to a family of transcription regulators characterized by a DNA-binding domain known as the HMG box. It plays fundamental roles in neural crest development, peripheral gliogenesis, and terminal differentiation of oligodendrocytes. In accord with its function as transcription factor, Sox10 contains two nuclear localization signals and is most frequently detected in the nucleus. In this study, we report that Sox10 is an active nucleocytoplasmic shuttle protein, competent of both entering and exiting the nucleus. We identified a functional Rev-type nuclear export signal within the DNA-binding domain of Sox10. Mutational inactivation of this nuclear export signal or treatment of cells with the CRM1-specific export inhibitor leptomycin B inhibited nuclear export and consequently nucleocytoplasmic shuttling of Sox10. Importantly, the inhibition of the nuclear export of Sox10 led to decreased transactivation of transfected reporters and endogenous target genes, arguing that continuous nucleocytoplasmic shuttling is essential for the function of Sox10. To our knowledge this is the first time that nuclear export has been reported and shown to be functionally relevant for any Sox protein.
Gazing estimation and correction from elliptical features of one iris

The accuracy of eye gaze estimation by image information is affected by several objective factors, including the image resolution, anatomical structure of eye, posture change, etc. Especially, the irregular movements of head and eye are the main problem and key technology being researched. We describe an effective way of estimating the eye gazing from the elliptical features of one iris under the conditions without auxiliary source, head fixing equipment or multiple-camera. Firstly, we give the preliminary estimations of the gazing direction and then obtain the vectors describing translation and rotation of eyeball movement using central projection on the cross section passing through the line-of-sight, which avoids the complex computations involved in known methods. We also disambiguate the solution on the basis of the experimental findings. Secondly, the error correction is carried on the BP neural network trained by a sample collection of the translation and rotation vectors. In our simulations, we achieve an accuracy of 0.8° on the test images which are different from the training images. The result is found to be better than that of the existing non-intrusive method with single-camera. The performance of the algorithm proves that the proposed method has excellent generalized abilities.
Local Weight Distribution of the (256, 93) Third-Order Binary Reed-Muller Code

Local weight distribution is the weight distribution of minimal codewords in a linear code. We give the local weight distribution of the (256, 93) third-order binary Reed-Muller code. For the computation, a coset partitioning algorithm is modified by using a binary shift invariance property. This reduces the time complexity by about 1/256 for the code. A necessary and sufficient condition for minimality in Reed-Muller codes is also presented.
A non-Gaussian generalization of the Airline model for robust seasonal adjustment

In their seminal book Time Series Analysis: Forecasting and Control, Box and Jenkins (1976) introduce the Airline model, which is still routinely used for the modelling of economic seasonal time series. The Airline model is for a differenced time series (in levels and seasons) and constitutes a linear moving average of lagged Gaussian disturbances which depends on two coefficients and a fixed variance. In this paper a novel approach to seasonal adjustment is developed that is based on the Airline model and that accounts for outliers and breaks in time series. For this purpose we consider the canonical representation of the Airline model. It takes the model as a sum of trend, seasonal and irregular (unobserved) components which are uniquely identified as a result of the canonical decomposition. The resulting unobserved components time series model is extended by components that allow for outliers and breaks. When all components depend on Gaussian disturbances, the model can be cast in state space form and the Kalman filter can compute the exact log-likelihood function. Related filtering and smoothing algorithms can be used to compute minimum mean squared error estimates of the unobserved components. However, the outlier and break components typically rely on heavy-tailed densities such as the t or the mixture of normals. For this class of non-Gaussian models, Monte Carlo simulation techniques will be used for estimation, signal extraction and seasonal adjustment. This robust approach to seasonal adjustment allows outliers to be accounted for, while keeping the underlying structures that are currently used to aid reporting of economic time series data. Copyright © 2006 John Wiley & Sons, Ltd.
Firms' Technological Trajectories and the Creation of Foreign Subsidiaries

Multinational firms are traditionally considered as firms possessing some technological lead and which are exploiting this proprietary advantage in international markets, but a growing literature has been arguing that multinational firms set up foreign subsidiaries not only as a means to exploit their own technology but also to enrich it. This paper provides some empirical evidence for this. The aim of the paper is to assess the effects of the creation of foreign subsidiaries on firms' technological trajectories.The idea is that by setting up subsidiaries in foreign countries, multinational firms can achieve some form of reverse technology transfer that can be expected to affect their technological trajectories.The empirical investigation uses data from 1992 to 1996 for a sample of 2185 Italian manufacturing firms. Results support the view that the creation of manufacturing subsidiaries has a positive impact on firms' productivity trajectories and this positive impact is greater when subsidiaries are created in regions where knowledge spillovers are expected to be relatively higher, such as the US.