Miracle-dz/UniFAR-FTUs huggingface dataset:
Help your patient "get" what you just said: a health literacy guide.

Half of all adults are unable to understand basic health information and services needed well enough to make appropriate health decisions, according to the Institute of Medicine. Findings from the 2003 National Assessment of Adult Literacy (NAAL), the National Center for Education Statistics’ only study of Americans’ ability to understand health-related information, painted a similarly grim picture. Although 53% of US adults had “intermediate” health literacy (HL), the NAAL found that up to 90% lacked the skills needed to manage their health and prevent disease. The National Patient Safety Foundation reports that low HL is associated with an additional $106 to $238 billion in health care costs per year. Among the reasons: • Up to half of all prescription and over-the-counter medications are taken incorrectly, which helps explain why roughly 1.5 million preventable adverse drug reactions occur each year. • Chronically ill patients incur higher health care costs as a result of low HL. Consider, for instance, that patients with asthma have more frequent hospitalizations, and patients with diabetes have higher glycohemoglobin (HbA1c) and a higher incidence of nephropathy and retinopathy. • Elderly patients with low HL are more likely to use the emergency department, and have significantly worse mental health and greater all-cause mortality than their counterparts with higher HL. Clearly, this is a problem primary care physicians cannot afford to ignore. The strategies discussed in the text and tables that follow will increase your awareness of the effects of limited HL—and help you take positive steps to address them.
Lung cancer risk prediction: Prostate, Lung, Colorectal And Ovarian Cancer Screening Trial models and validation.

INTRODUCTION Identification of individuals at high risk for lung cancer should be of value to individuals, patients, clinicians, and researchers. Existing prediction models have only modest capabilities to classify persons at risk accurately. METHODS Prospective data from 70 962 control subjects in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) were used in models for the general population (model 1) and for a subcohort of ever-smokers (N = 38 254) (model 2). Both models included age, socioeconomic status (education), body mass index, family history of lung cancer, chronic obstructive pulmonary disease, recent chest x-ray, smoking status (never, former, or current), pack-years smoked, and smoking duration. Model 2 also included smoking quit-time (time in years since ever-smokers permanently quit smoking). External validation was performed with 44 223 PLCO intervention arm participants who completed a supplemental questionnaire and were subsequently followed. Known available risk factors were included in logistic regression models. Bootstrap optimism-corrected estimates of predictive performance were calculated (internal validation). Nonlinear relationships for age, pack-years smoked, smoking duration, and quit-time were modeled using restricted cubic splines. All reported P values are two-sided. RESULTS During follow-up (median 9.2 years) of the control arm subjects, 1040 lung cancers occurred. During follow-up of the external validation sample (median 3.0 years), 213 lung cancers occurred. For models 1 and 2, bootstrap optimism-corrected receiver operator characteristic area under the curves were 0.857 and 0.805, and calibration slopes (model-predicted probabilities vs observed probabilities) were 0.987 and 0.979, respectively. In the external validation sample, models 1 and 2 had area under the curves of 0.841 and 0.784, respectively. These models had high discrimination in women, men, whites, and nonwhites. CONCLUSION The PLCO lung cancer risk models demonstrate high discrimination and calibration.
Murders of Nota Roja: Truth and Justice in Mexican Crime News

EDUCATION 1997 Ph.D., History Department, University of Texas at Austin. Dissertation: “Criminals in Mexico City, 1900-1931: A Cultural History. ” Director: Jonathan C. Brown. 1993 M.A., Institute of Latin American Studies, University of Texas at Austin. Thesis: “The Discourse about Alcoholism and Criminality in Mexico City, 1890-1917. ” 1990 B.A. (Licenciado en Historia), Universidad Nacional Autónoma de México, Mexico City. Thesis: “Congreso y Revolución: El Parlamentarismo en la XXVI Legislatura. ” Director: Horacio Crespo.
ICP Public Health and Mycobacterium avium subsp . paratuberculosis in the environment 384 DEVELOPMENT AND OPTIMISATION OF A MULTIPLEX SNP GENOTYPING ASSAY FOR MYCOBACTERIUM PARATUBERCULOSIS

Previous studies based on whole genome sequencing have demonstrated limited genetic diversity within Mycobacterium avium subsp. paratuberculosis (MAP) strains isolated from human hosts [1]. In contrast, animal derived MAP stains are genetically more diverse. In order to understand the possible zoonotic transmission of MAP a robust genotyping platform that discriminates different strain types is required. A total of 15 SNPs located in 12 loci that have previously been shown to discriminate different MAP strain types were selected for this assay [1]. This paper describes the development and optimisation of this platform based on Luminex xTAG technology. This assay can be used to examine the geographical distribution and host specificity of different MAP strains.
Principles of power management in a smart microgrid based on Std. IEC 61850

In recent years, the structure of the electrical power system has changed, and all aspects of power generation have shifted towards bidirectional and smart methodology. The Microgrid (MG) as a popular concept for the modern grid and advanced communication techniques play major role in future smart grids. In this regard, this paper presents the principles of MG power management from communication point of view. Moreover, there have been recent efforts to standardize MGs, and it is in terms of these advances that the current paper present the investigation based on IEC 61850 standards. Finally, the hierarchical levels of both the power and communications sides are discussed, and the responsibility of each level is summarized based on the standards.
Decentralized detection of violations of Service Level Agreements using Peer-to-Peer technology

Critical networked services established between service providers and customers are expected to operate respecting Service Level Agreements (SLAs). An interesting possibility to monitor such SLAs is using active measurement mechanisms. However, these mechanisms are expensive in terms of network devices resource consumption and also increase the network load because of the injected traffic. In addition, if the number of SLA violations in a given time is higher than the number of available measurement sessions (common place in large and complex network infrastructures), certainly some violations will be missed. The current best practice, the observation of just a subset of network destinations driven by human administrators expertise, is error prone, does not scale well, and is ineffective on dynamic network conditions. This practice can lead to SLA violations being missed, which invariably affects the performance of several applications. In the present thesis, we advocate the use of Peer-to-Peer (P2P) technology to improve the detection of SLA violations. Such use is described using principles to control active measurement mechanisms. These principles are accomplished through strategies to activate measurement sessions. In this context, the thesis contains several contributions towards SLA monitoring, conceptually as well pragmatically. The findings show properties which improve the detection of SLA violations in terms of the number of detected violations and the adaptivity to network dynamics. We expect that such findings can lead to better SLA monitoring tools and methods.
Matrix Eigenproblem Approach for A Class of Positive Dimensional Multivariate Polynomial System Solving 1)

The matrix eigenproblem approach for zero-dimensional multivariate polynomial system solving has been studied. The purpose of this paper is to apply the approach to a class of positive dimensional multivariate polynomial system which is called pseudo zero-dimensional system. In this case we can decide its reducibility, and when it is reducible, a set of polynomial can be determined from the eigenvec- tor of matrix constructed. The union of this set and the given system will yield a representation of a component of the given system.
Integrated Transcriptomic and Proteomic Analysis of the Bile Stress Response in a Centenarian-originated Probiotic Bifidobacterium longum BBMN68*

Bifidobacteria are natural inhabitants of the human gastrointestinal tract and well known for their health-promoting effects. Tolerance to bile stress is crucial for bifidobacteria to survive in the colon and to exert their beneficial actions. In this work, RNA-Seq transcriptomic analysis complemented with proteomic analysis was used to investigate the cellular response to bile in Bifidobacterium longum BBMN68. The transcript levels of 236 genes were significantly changed (≥ threefold, p < 0.001) and 44 proteins were differentially abundant (≥1.6-fold, p < 0.01) in B. longum BBMN68 when exposed to 0.75 g l−1 ox-bile. The hemolysin-like protein and bile efflux systems were significantly over produced, which might prevent bile adsorption and exclude bile, respectively. The cell membrane composition was modified probably by an increase of cyclopropane fatty acid and a decrease of transmembrane proteins, resulting in a cell membrane more impermeable to bile salts. Our hypothesis was later confirmed by surface hydrophobicity assay. The transcription of genes related to xylose utilization and bifid shunt were up-regulated, which increased the production of ATP and reducing equivalents to cope with bile-induced damages in a xylan-rich colon environment. Bile salts signal the B. longum BBMN68 to gut entrance and enhance the expression of esterase and sortase associated with adhesion and colonization in intestinal tract, which was supported by a fivefold increased adhesion ability to HT-29 cells by BBMN68 upon bile exposure. Notably, bacterial one-hybrid and EMSA assay revealed that the two-component system senX3-regX3 controlled the expression of pstS in bifidobacteria and the role of this target gene in bile resistance was further verified by heterologous expression in Lactococcus lactis. Taken altogether, this study established a model for global response mechanisms in B. longum to bile.
Siglec-9, a Novel Sialic Acid Binding Member of the Immunoglobulin Superfamily Expressed Broadly on Human Blood Leukocytes*

Here we characterize the properties and expression pattern of Siglec-9 (sialic acid-bindingIg-like lectin-9), a new member of the Siglec subgroup of the immunoglobulin superfamily. A full-length cDNA encoding Siglec-9 was isolated from a dibutyryl cAMP-treated HL-60 cell cDNA library. Siglec-9 is predicted to contain three extracellular immunoglobulin-like domains that comprise an N-terminal V-set domain and two C2-set domains, a transmembrane region and a cytoplasmic tail containing two putative tyrosine-based signaling motifs. Overall, Siglec-9 is ∼80% identical in amino acid sequence to Siglec-7, suggesting that the genes encoding these two proteins arose relatively recently by gene duplication. Binding assays showed that, similar to Siglec-7, Siglec-9 recognized sialic acid in either the α2,3- or α2,6-glycosidic linkage to galactose. Using a specific mAb, Siglec-9 was found to be expressed at high or intermediate levels by monocytes, neutrophils, and a minor population of CD16+, CD56− cells. Weaker expression was observed on ∼50% of B cells and NK cells and minor subsets of CD8+ T cells and CD4+ T cells. These results show that despite their high degree of sequence similarity, Siglec-7 and Siglec-9 have distinct expression profiles.
N-acetyltransferase (NAT2) genotype and susceptibility of sporadic Alzheimer's disease.

The importance of environmental aggression and individual susceptibility to develop Alzheimer's Disease (AD) has been suggested by epidemiological studies on both typical familial and sporadic AD cases. In order to elucidate functions that can influence the susceptibility to AD pathogenesis, we genotyped a group of 53 sporadic late-onset AD patients, matched control individuals and a larger randomly selected non-demented population for the N-acetyltransferase (NAT2). We determined the relative frequencies of individual allele combinations that define a broad range of acetylator phenotypes. Inter-individual variability in the cytotoxic and genotoxic responses to a wide diversity of environmental chemicals is known to result from the polymorphism of NAT2 as well as other drug-metabolizing-enzyme genes. The results presented are the first to demonstrate a significant difference in the NAT2 genotype profiles of sporadic AD patients compared with the healthy population. A lower frequency of the recessive alleles NAT2*6 (chi-squared 1 d.f. = 12.56, P < 0.0004) and NAT2*5B (chi-squared 1 d.f. = 6.72, P < 0.01) was found among the AD population compared with control individuals, which was concomitant with a significantly higher number of NAT2*4 fully active allele homozygotes and heterozygotes (chi-squared 1 d.f. = 5.69, P = 0.017). The most notable observation was the absence of NAT2*5B/NAT2*6 heterozygotes among cases while being present in 22.5% of control individuals (chi-squared 1 d.f. = 13.08, P = 0.0003). These observations indicate that NAT2 is a potential low-penetrance gene in AD pathogenesis, determining an individual susceptibility trait predisposing to this degenerative disease.
Taxes and Quality: A Market-Level Analysis

Aconventional assumption of product homogeneity when the commodity of interest is actually heterogeneous will lead to errors in an analysis of the incidence of policies, such as taxes. In this article, an equilibrium displacement model is used to derive analytical solutions for price, quantity, and quality effects of ad valorem and per unit taxes. The results show how parameters determine the effects of tax policies on quality. The potential for tax-induced distortions in quality, and the distributive consequences of those distortions, are illustrated in a case study of the market for Australian wine.
Ultra-low-power RF transceivers for WBANs in medical applications

The paper presents two ultra-low-power ISM band RF transceivers for wireless body area networks (WBANs) in medical applications. Two RF transceivers with an asymmetric architecture are proposed to achieve high energy efficiency according to the asymmetric communication in WBANs. The 2.4 GHz transceiver consists of an OOK receiver (RX) with wake-up circuit (WuRx) and a BFSK/4FSK high speed transmitter (TX) with fast lock-in PLL. The 400 MHz transceiver consists of an OOK RX and a QPSK/8PSK/16QAM TX with a current-reused PLL. Different frequency bands and modulation schemes are adopted in the transceivers to fit different energy-efficient applications. Some novel circuit techniques: asymmetric transceiver architecture, phase-locked loop (PLL) synthesizer with a direct frequency presetting, passive wake-up circuit, and CMOS non-volatile memory (NVM) are used to reduce the power consumption and increase the performance. The transceivers are implemented in 0.18 um RF CMOS process. The max date rate of the TX is 7.5 Mbps with energy efficiency of less than 1 nJ/bit. The RX achieves a sensitivity of -55 dBm at a 100 kbps OOK data rate while consuming just 210 uW power.
Deregulation of RB1 expression by loss of imprinting in human hepatocellular carcinoma

The tumour suppressor gene RB1 is frequently silenced in many different types of human cancer, including hepatocellular carcinoma (HCC). However, mutations of the RB1 gene are relatively rare in HCC. A systematic screen for the identification of imprinted genes deregulated in human HCC revealed that RB1 shows imprint abnormalities in a high proportion of primary patient samples. Altogether, 40% of the HCC specimens (16/40) showed hyper‐ or hypomethylation at the CpG island in intron 2 of the RB1 gene. Re‐analysis of publicly available genome‐wide DNA methylation data confirmed these findings in two independent HCC cohorts. Loss of correct DNA methylation patterns at the RB1 locus leads to the aberrant expression of an alternative RB1–E2B transcript, as measured by quantitative real‐time PCR. Demethylation at the intron 2 CpG island by DNMT1 knock‐down or aza‐deoxycytidine (DAC) treatment stimulated expression of the RB1–E2B transcript, accompanied by diminished RB1 main transcript expression. No aberrant DNA methylation was found at the RB1 locus in hepatocellular adenoma (HCA, n = 10), focal nodular hyperplasia (FNH, n = 5) and their corresponding adjacent liver tissue specimens. Deregulated RB1 expression due to hyper‐ or hypomethylation in intron 2 of the RB1 gene is found in tumours without loss of heterozygosity and is associated with a decrease in overall survival (p = 0.032) if caused by hypermethylation of CpG85. This unequivocally demonstrates that loss of imprinting represents an important additional mechanism for RB1 pathway inactivation in human HCC, complementing well‐described molecular defects. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
A framework for autonomic workload management in DBMSs

Abstract In today's database server environments, multiple types of workloads can be present in a system simultaneously. Workload types may include on-line transaction processing and business intelligence. Workloads may also have different levels of business importance and distinct performance objectives, which are typically derived from service level agreements. An autonomic workload management system for database management systems (DBMSs) dynamically monitors and controls the flow of the workloads to help DBMSs achieve the desired performance objectives. In this paper, we present a framework and a prototype implementation for autonomic workload management in DBMSs. The framework and the prototype provide the ability to achieve performance objectives of workloads with diverse characteristics, different levels of business importance and varying resource demands while protecting DBMSs against performance failure. The prototype system is implemented on top of IBM® DB2® Workload Manager. Initial experiments using the prototype system are presented to demonstrate the effectiveness of the framework.
Starvation Time and Successive Collection Effects on Leeches Saliva Collection Quantity and Proteins Quality and Quantity in Wet Season

The salivary gland secretion of the haematophagous animals, leeches, has attracted the attention of therapists since the extreme old ages due to its wide range of medical properties. Thus, many researches have been done to develop and optimize new methods to collect leech saliva with high quality and quantity. In the present study, we aimed to evaluate the effects of starvation period and repeated collection on the quality and quantity of leech saliva extract LSE and its contents of proteins during the rainy season. Protein recovery in the LSE was also studied after first collection. It was found that leeches are able to produce protein-containing saliva whenever fed during the whole study period of 18 weeks with varied protein concentrations. The results showed that the highest protein concentrations (105-91 μg/mL) were produced after 12-15 weeks of starvation. The results of successive collection showed that leeches are able to produce proteins and peptides whenever they suck the solution after first collection with some varies in the concentrations. The concentrations varied between 0 and 72% of the initial concentration. Gel electrophoresis results showed absence for some bands when the concentrations are too low. Also the results showed that leeches are able to recover about 42% of their initial proteins concentration within four weeks of starvation after first feeding. The gel electrophoresis results showed the closeness between the first and second collections. To conclude, all test factors (starvation period, successive collection and recovery test) were shown to have an important impact on protein concentration of leech saliva and therefore its medicinal affectivity. The mentioned results are reported for the first time and they open the gate for further studies.
Tactile feedback applied to computer mice

Most computer systems use a mouse as the input device for menu selection, pointing, and manipulation of screen objects. The user can get visual information from the screen only about the position of the mouse and the action that was initiated. In contrast, during the manipulation of real objects, the visual channel is only responsible for giving broader information about the action, whereas the motoric action itself is predominantly controlled by tactile information fed by interoceptive and exteroceptive sensory signals. Consequently, working with a standard computer mouse requires concentration primarily on the visual system, leading to strain reactions. Furthermore, human motor action is slower when only visual sense is used and tactile sense is ignored. In respect to this situation, it is proposed that a computer mouse be enhanced with additional tactile feedback to approximate more closely real object handling, thereby reducing strain reactions. To test this hypothesis, a standard computer mouse was e.
Variation in the iodine concentrations of foods: considerations for dietary assessment.

BACKGROUND Food-composition tables typically give measured nutrient concentrations in foods as a single summary value, often the mean, without providing information as to the shape of the distribution. OBJECTIVE Our objective was to explore how the statistical approach chosen to describe the iodine concentrations of foods affects the proportion of the population identified as having either insufficient or excessive iodine intakes. DESIGN We used food intake data reported by the 2009-2010 NHANES and measured iodine concentrations of Total Diet Study (TDS) foods from 4 US regions sampled in 2004-2011. We created 4 data sets, each by using a different summary statistic (median, mean, and 10th and 90th percentiles), to represent the iodine concentration distribution of each TDS food. We estimated the iodine concentration distribution of each food consumed by NHANES participants as the 4 iodine concentration summary statistics of a similar TDS food and used these, along with NHANES food intake data, to develop 4 estimates of each participant's iodine intake on each survey day. Using the 4 estimates in turn, we calculated 4 usual iodine intakes for each sex- and age-specific subgroup. We then compared these to guideline values and developed 4 estimates of the proportions of each subgroup with deficient and excessive usual iodine intakes. RESULTS In general, the distribution of iodine intakes was poorly characterized when food iodine concentrations were expressed as mean values. In addition, mean values predicted lower prevalences of iodine deficiency than did median values. For example, in women aged 19-50 y, the estimated prevalence of iodine deficiency was 25% when based on median food iodine concentrations but only 5.8% when based on mean values. CONCLUSION For nutrients such as iodine with highly variable concentrations in important food sources, we recommend that food-composition tables provide useful variability information, including the mean, SD, and median.
, Marko exercise training in lung transplant skeletal muscle and mitochondrial creatine kinase is enhanced after Functional coupling of adenine nucleotide translocase

289:1144-1154, 2005. First published Jul 14, 2005; Am J Physiol Regul Integr Comp Physiol Imbeaud, Valdur Saks and Christophe Pison Vendelin, Jean-Christian Borel, Rachid Hacini, Olivier Chavanon, Sandrine Karen Guerrero, Bernard Wuyam, Paulette Mezin, Isabelle Vivodtzev, Marko exercise training in lung transplant skeletal muscle and mitochondrial creatine kinase is enhanced after Functional coupling of adenine nucleotide translocase