Miracle-dz/UniFAR-FTUs huggingface dataset:
Employment in the North of Russia: Microdata Analysis

In the North of Russia employment and migration are closely related. The reduction in population and employment in the northern regions of the Russian Federation for more than two decades together with the high economic potential of the Russian North seems to be paradoxical. Perhaps this situation is related to the mismatch in demand and supply of labor in the northern regions of Russia. The model of the local labor market equilibrium and the theory of compensating differentials predict higher wages in the amenity-poor regions. It means that less qualified workers can earn more in the High North compared with the other regions of the country. The hypothesis was that less qualified employees have higher probability of being employed in the High North regions of Russia than in the rest of the country. Using the binary logit models, probabilities of being employed in the North of Russia and the rest of the country were estimated at the base of microdata of the Survey of the Labour Force, provided by the Federal State Statistics Service. The results showed that the population in the High North regions of Russia is more economically active compared with the rest of the country, what is especially true for women. The working age and professional education make the highest marginal effects in the North and the rest of the Russian Federation. Secondary and tertiary education increases, while primary education reduces, the probability of being employed in the High North regions of Russia compared with the rest of the country.
Integration of Environmental Signals Controls Expression of Bordetella Heme Utilization Genes

ABSTRACT The Bordetella pertussis heme utilization gene cluster hurIR bhuRSTUV encodes regulatory and transport functions required for assimilation of iron from heme and hemoproteins. Expression of the bhu genes is iron regulated and heme inducible. The putative extracytoplasmic function (ECF) σ factor, HurI, is required for heme-responsive bhu gene expression. In this study, transcriptional activation of B. pertussis bhu genes in response to heme compounds was shown to be dose dependent and specific for heme; protoporphyrin IX and other heme structural analogs did not activate bhu gene expression. Two promoters controlling expression of the heme utilization genes were mapped by primer extension analysis. The hurI promoter showed similarity to σ70-like promoters, and its transcriptional activity was iron regulated and heme independent. A second promoter identified upstream of bhuR exhibited little similarity to previously characterized ECF σ factor-dependent promoters. Expression of bhuR was iron regulated, heme responsive, and hurI dependent in B. pertussis, as shown in a previous study with Bordetella bronchiseptica. Further analyses showed that transcription originating at a distal upstream site and reading through the hurR-bhuR intergenic region contributes to bhuR expression under iron starvation conditions in the absence of heme inducer. The pattern of regulation of the readthrough transcript was consistent with transcription from the hurI promoter. The positions and regulation of the two promoters within the hur-bhu gene cluster influence the production of heme transport machinery so that maximal expression of the bhu genes occurs under iron starvation conditions only in the presence of heme iron sources.
On the Macroeconomic Performance of the Euro Area

This paper examines whether Euro Area countries would have faced a more favorable inflation output variability tradeoff without the Euro. We provide evidence that this claim is true for the periods of the Great Recession and the European Sovereign Debt Crisis. For the Euro Area as a whole, the deterioration of the tradeoff becomes insignificant with Draghi’s ‘whatever it takes’ announcement onwards. However, our more detailed analysis shows that the detrimental effect of the Euro is more severe for peripheral Euro Area countries and that ECB policies have been less effective for these countries. These findings point to structural differences among Euro Area countries as the explanation of the detrimental effect of the Euro as ECB policies can be denoted ‘one size must fit all’ policies. We base our results on a novel empirical strategy that, consistent with monetary theory, models the joint determination of the variability of inflation and output conditional on structural supply shocks. Moreover, our findings are robust to potential endogeneity concerns related to adopting the Euro.
Simultaneous evaluation of long-lasting knee synovitis in patients undergoing arthroplasty by power Doppler ultrasonography and contrast-enhanced MRI in comparison with histopathology.

OBJECTIVES We simultaneously assessed ultrasonography (US) and magnetic resonance imaging (MRI) in comparison with histopathological changes in the knee joints of long-lasting arthritis patients. METHODS We studied 15 patients with rheumatoid arthritis and 5 patients with osteoarthritis, who underwent total knee arthroplasty. On the day before surgery, the joints were examined by US and contrast-enhanced MRI. In US, synovitis was graded with 0-3 grey scale (GSUS) and power Doppler (PDUS). In MRI, synovitis was graded according to OMERACT-RAMRIS (grade 0-3). Synovial tissue samples were obtained during arthroplasty and evaluated on the basis of inflammatory cell infiltrates (grade 0-3), synovial lining layer thickness (grade 0-3) and vascularity (grade 0-3). RESULTS Positive findings of PDUS and contrast-enhanced MRI were 45% and 85% of 20 operated joints, respectively. GSUS, PDUS and MRI synovitis were well correlated with overall histopathological grades of synovitis (Spearman correlation coefficients 0.48, 0.84 and 0.48, p<0.05, p<0.01 and p<0.05, respectively). Moreover, positive PDUS findings were closely associated with all pathological comportments of synovitis including inflammatory cell infiltrates, synovial lining layer thickness and vascularity. CONCLUSIONS The present study revealed that positive PDUS findings more faithfully illustrated active synovitis than MRI, whereas contrast-enhanced MRI was more sensitive in detecting synovitis in patients with long-lasting arthritis. It is important to understand distinct features of the both modalities for clinical assessment of chronic joint diseases.
Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease.

Resistance to insulin-mediated glucose disposal has been postulated to predispose individuals to a cluster of associated abnormalities (Syndrome X) known to increase risk of cardiovascular disease (CVD). Although several abnormalities subsumed under the rubric of Syndrome X have been shown to predict CVD, there has been no prospective study evaluating the power of insulin resistance, the putative fundamental defect in the syndrome, in this context. Therefore, this study was initiated to evaluate the hypothesis that resistance to insulin-mediated glucose disposal would predict the development of CVD in healthy volunteers. To accomplish this goal, 147 normal, healthy, nonobese, volunteers were evaluated [4.7 +/- 0.1 yr (mean +/- SEM)] after baseline measurements of steady state plasma glucose concentration (an estimate of insulin-mediated glucose disposal), as well as other CVD risk factors. Clinical end points developed in 13 subjects during the follow-up period; hypertension in 5, coronary artery disease in 4, cerebrovascular accident in 3, and peripheral vascular disease in 1. There was a significant univariate relationship between SSPG and CVD (P < 0.002), with the majority of the events taking place in the tertile of subjects with the highest SSPG concentration, i.e. the greatest degree of insulin resistance. In contrast, no CVD events were observed in the tertile with the lowest SSPG concentrations; the most insulin sensitive. SSPG was also related significantly to diastolic blood pressure, triglyceride, and low-density lipoprotein and high-density lipoprotein cholesterol concentrations, and the glucose and insulin responses to oral glucose. All of these relationships were independent of age, gender, body mass index, estimates of physical activity, and smoking history. When SSPG was paired with each of the other variables in a series of multiple regression models, only SSPG, or insulin response, were independent predictors of CVD events. In conclusion, approximately one of every five healthy, nonobese subjects in the most insulin-resistant tertile, followed for approximately 5 yr, had a serious clinical event. These data highlight the importance of insulin resistance as a predictor of CVD.
A new robust control based on active disturbance rejection controller for speed sensorless induction motor

This paper aims to present a new robust command called active disturbance rejection controller (ADRC) applied to the sensorless induction motor and introduces the problem of the parameters, which significantly deteriorate the performance of the control, this variation introduces an important role in the loss of dynamic performance in an undesirable coupling between flux and torque of the machine. This paper offers a new scheme for estimation of induction motor speed using αβ representation of the model in the stationary reference frame and measurements of accessible motor variables only (currents, voltages and speed). A second-order of MRAS based sliding mode estimator is designed for speed estimation. The proposed schemes are implemented using MATLAB simulation, improve the system robustness against motor parameter variations and increase the performance of the speed loop controller.
Inquiries that matter: How social studies teachers employ historical inquiry practices to support social justice civic goals

This paper reports findings of one case of a larger multi-case study. The paper highlights the opportunities and constraints present in the activity system of one exemplary elementary teacher who uses historical inquiry practices to support the social justice-oriented civic goals she holds for her students. Her work offers insight into promising connections between disciplinary inquiry practices and social justice education particular to elementary teaching and but it also reveals important constraints to consider that are prevalent enough to limit even an exemplary elementary social studies teacher’s social justice practice. Paper Two: Economics education through a historian’s task and not the master’s tools Abstract: This paper highlights the opportunities and constraints present in the activity system of a 7 grade social studies teacher with social justice oriented civic goals who uses historical inquiry practices to support a critical inquiry of economic systems. His work offers insight into promising opportunities into the uses of historical inquiry practices in This paper highlights the opportunities and constraints present in the activity system of a 7 grade social studies teacher with social justice oriented civic goals who uses historical inquiry practices to support a critical inquiry of economic systems. His work offers insight into promising opportunities into the uses of historical inquiry practices in
Pairing of P1 plasmid partition sites by ParB

The mechanisms by which bacterial plasmids and chromosomes are partitioned are largely obscure, but it has long been assumed that the molecules to be separated are initially paired, as are sister chromatids in mitosis. We offer in vivo evidence that the partition protein ParB encoded by the bacterial plasmid P1 can pair cis‐acting partition sites of P1 inserted in a small, multicopy plasmid. ParB was shown previously to be capable of extensive spreading along DNA flanking the partition sites. Experiments in which ParB spreading was constrained by physical roadblocks suggest that extensive spreading is not required for the pairing process.
Towards learning domain-independent planning heuristics

Automated planning remains one of the most general paradigms in Artificial Intelligence, providing means of solving problems coming from a wide variety of domains. One of the key factors restricting the applicability of planning is its computational complexity resulting from exponentially large search spaces. Heuristic approaches are necessary to solve all but the simplest problems. In this work, we explore the possibility of obtaining domain-independent heuristic functions using machine learning. This is a part of a wider research program whose objective is to improve practical applicability of planning in systems for which the planning domains evolve at run time. The challenge is therefore the learning of (corrections of) domain-independent heuristics that can be reused across different planning domains.
Carotid angioplasty and stent placement: comparison of transcranial Doppler US data and clinical outcome with and without filtering cerebral protection devices in 509 patients.

PURPOSE To prospectively evaluate emboli detected at transcranial Doppler ultrasonography (US) and outcome of carotid angioplasty and stent placement and compare these findings in patients treated with the use of filtering cerebral protection devices (CPDs) with the findings in patients treated without the use of filtering CPDs. MATERIALS AND METHODS This study was approved by the institutional human research committee. Written informed consent was obtained for all patients. Patients were divided into three groups: 161 patients treated before filtering CPDs had become available (group 1), 151 patients treated with filtering CPDs (group 2), and 197 patients treated without CPDs after CPDs had become available (group 3). Clinical end points were cerebral ischemic events and death. Transcranial Doppler US end points included isolated microemboli, microembolic showers, macroemboli, and distal thrombus. The procedure was divided into five phases: wiring, predilation, stent deployment, postdilation, and CPD handling. Data not distributed normally were analyzed with the Mann-Whitney U statistic. For binomial data, the chi(2) test was used. P < . 05 indicated statistical significance. RESULTS For each phase, median and interquartile range (IQR) for isolated microemboli in group 2 versus group 3 were as follows: wiring, 51 (IQR, 31-69) versus 27 (IQR, 15-48); predilation, 19 (IQR, 13-33) versus 13 (IQR, 8-19); stent deployment, 64 (IQR, 46-82) versus 48.5 (IQR, 33.25-66); and postdilation, 24 (IQR, 14-39) versus 16 (IQR, 11-27.5) (P < .001 for each phase). Median and IQR for microembolic showers were as follows: wiring, 0 (IQR, 0-3) versus 0 (IQR, 0-0); predilation, 1.5 (IQR, 0-4) versus 0 (IQR, 0-2); stent deployment, 22 (IQR, 11-36) versus 11 (IQR, 6-17); postdilation, three (IQR, 0-9) versus one (IQR, 0-4); (postdilation phase, P = .001; all other phases, P < .001). Median for isolated microemboli in group 1 versus groups 2 and 3 combined were as follows: predilation, 10 (IQR, 5-22.75) versus 16 (IQR, 9-25) (P = .001); stent deployment, 32 (IQR, 15-58) versus 54 (IQR, 40.5-74) (P < .001); and postdilation, 11 (IQR, 6-19) versus 18 (IQR, 12-33) (P < .001). Median for microembolic showers during stent deployment were six (IQR, 1-14) versus 13 (IQR, 7-26) (P < .001). Five patients died, and five major strokes and 14 minor strokes occurred. Eight macroemboli occurred in unprotected procedures; six distal thrombi occurred in protected procedures. CONCLUSION Carotid angioplasty and stent placement yielded more microemboli in patients treated with filtering CPDs than in unprotected procedures. The infrequent occurrence of cerebral sequelae did not allow comprehensive statistical comparison between groups.
Integral Representation of Probability Density of Stochastic Volatility Models and Timer Options

This paper contributes a generic probabilistic method to derive explicit exact probability densities for stochastic volatility models. Our method is based on a novel application of the exponential measure change in [Z. Palmowski & T. Rolski (2002) A technique for exponential change of measure for Markov processes, Bernoulli 8(6), 767–785]. With this generic approach, we first derive explicit probability densities in terms of model parameters for several stochastic volatility models with nonzero correlations, namely the Heston 1993, 3/2, and a special case of the α-Hypergeometric stochastic volatility models recently proposed by [J. Da Fonseca & C. Martini (2016) The α-Hypergeometric stochastic volatility model, Stochastic Processes and their Applications 126(5), 1472–1502]. Then, we combine our method with a stochastic time change technique to develop explicit formulae for prices of timer options in the Heston model, the 3/2 model and a special case of the α-Hypergeometric model.
The development of effective oral production through the use of technological resources on students from seventh grade at Santo Domingo de Guzman, school year 2016-2017

The present Project was conducted with students of seventh grade at Santo Domingo De Guzman. The project was designed for students to improve their learning speaking skills because it is one the most challenging skills that students face when learning the English language. The general objective of this project was to analyse the impact that educational portals have in the learning process. Schools face the obstacle on the daily basis with all their English learning students, but involving technology there should show progress. It has become a predictable problem among teachers, students, parents and the education system when English is mentioned, especially if technology in such language is also involved….
Valuing forest park attributes by giving consideration to the tourist satisfaction

Despite the economic valuation of forest park resources has triggered a great deal of interest to the research community and park management, up to now no attention has been paid to the effect of psychological factors such as tourist satisfaction, which could potentially play a considerable role in contributing to the park resource valuation. This article attempts to fill this niche by carrying out a study on the economic valuation of the Xian-Ren-Tai National Forest Park in China, taking consideration of the tourist satisfaction. In the process, the choice experiment survey was used for data collection. Then, both conditional logit (CL) and random parameter logit models were used in parameter estimations to examine the factors that could potentially impact on the tourists’ willingness to pay. Results indicate that the tourists attach the greatest importance to the park’s natural environment and traffic conditions, and yet the level of tourists’ satisfaction on their tourism experience plays a big part in explaining the valuation results. Tourists who uphold a high level of satisfaction tend to pay more for the park attribute improvement than those with less satisfaction ones. The estimated compensating variation of the overall current park attributes has reached ¥184.95 per person per trip, of which 12.83% shall be attributable to the tourist satisfaction.
Identifying how Visually Impaired People Explore Raised-line Diagrams to Improve the Design of Touch Interfaces

Raised-line diagrams are widely used by visually impaired (VI) people to read maps, drawings or graphs. While previous work has identified general exploration strategies for raised-line drawings, we have limited knowledge on how this exploration is performed in detail and how it extends to other types of diagrams such as maps or graphs, frequently used in specialized schools. Such information can be crucial for the design of accessible interfaces on touchscreens. We conducted a study in which participants were asked to explore five types of raised-line diagrams (common drawings, perspective drawings, mathematical graphs, neighborhood maps, and geographical maps) while tracking both hands fingers. Relying on a first set of results, we proposed a set of design guidelines for touch interfaces.
Unique topographic separation of two spectral classes of cones in the mouse retina

We have found two immunologically distinguishable cone types in the retina of the mouse, each localized to two opposite halves of the eye. One cone type was labelled by the monoclonal antibody COS‐1 specific to the middle‐to‐long wave sensitive visual pigment of the mammals, while the other type was stained by the shortwave‐specific monoclonal antibody (OS‐2). These results were confirmed with other antibodies directed against specific sequences of the visual pigments. As a result of the uneven distribution of the two cone types the mouse retina is divided into two fields separated by an oblique meridional line. The middlewave sensitive cones were present exclusively in the dorsal half of the mouse retina (M‐field). The overwhelming majority of the shortwave sensitive cones occupied the ventral half (S‐field), and only a small number was scattered among the middlewave sensitive cones in the dorsal retina. The ratio of the two cone types in the M‐field corresponds to what has been found in the retina of other mammals, including rodents such as the gerbil and the rat. The S‐field represents an entirely unique area with the unusually great number of shortwave sensitive cones and with the complete lack of the middlewave sensitive ones.
c-mos expression in mouse oocytes is controlled by initiator-related sequences immediately downstream of the transcription initiation site

We have employed transient expression assays to analyze the sequences that direct c-mos transcription in mouse oocytes. Plasmids containing the chloramphenicol acetyltransferase (CAT) gene fused to either a 2.4-kb or a 731-bp fragment from the 5'-flanking region of c-mos produced similar levels of CAT activity when injected into nuclei of growing oocytes. BAL 31 deletions revealed that sequences up to 20 bp upstream of the major transcription start site could be removed without any significant loss of CAT activity. Promoter activity only decreased when these deletions closely approached the transcription start site, which was mapped at 53 nucleotides upstream of the first ATG in the c-mos open reading frame. On the other hand, deletion of sequences within 20 nucleotides downstream of the transcription initiation site resulted in a 10-fold reduction in CAT expression. A similar decrease in promoter activity was observed as a result of point mutations in these 5' untranslated sequences. Thus, sequences immediately downstream of the transcription start site, including a consensus sequence (PyPyCAPyPyPyPyPy) present in the initiator elements of several genes, appear to regulate c-mos expression in mouse oocytes. Reverse transcription-polymerase chain reaction analysis of RNA from injected oocytes showed that this regulation is manifest at the transcriptional level. Expression of c-mos in mouse oocytes thus appears to be directed by a simple promoter consisting only of sequences immediately surrounding the transcription start site, including an initiator element in the untranslated leader.