Miracle-dz/UniFAR-FTUs huggingface dataset:
Making proteomics data accessible and reusable: Current state of proteomics databases and repositories

Compared to other data‐intensive disciplines such as genomics, public deposition and storage of MS‐based proteomics, data are still less developed due to, among other reasons, the inherent complexity of the data and the variety of data types and experimental workflows. In order to address this need, several public repositories for MS proteomics experiments have been developed, each with different purposes in mind. The most established resources are the Global Proteome Machine Database (GPMDB), PeptideAtlas, and the PRIDE database. Additionally, there are other useful (in many cases recently developed) resources such as ProteomicsDB, Mass Spectrometry Interactive Virtual Environment (MassIVE), Chorus, MaxQB, PeptideAtlas SRM Experiment Library (PASSEL), Model Organism Protein Expression Database (MOPED), and the Human Proteinpedia. In addition, the ProteomeXchange consortium has been recently developed to enable better integration of public repositories and the coordinated sharing of proteomics information, maximizing its benefit to the scientific community. Here, we will review each of the major proteomics resources independently and some tools that enable the integration, mining and reuse of the data. We will also discuss some of the major challenges and current pitfalls in the integration and sharing of the data.
Consumers' Expectations of Fair Data Collection and Usage -- A Mixed Method Analysis

Understanding consumers' expectations of fair data collection and usage (CEFD) in an online environment is critical in a time when the analysis of customer data is increasingly important for companies. Drawing on the psychological contract and justice theory, this study developed a holistic picture of customer expectations by applying a two-stage research design. In stage 1, in-depth interviews with customers and experts were conducted to gain an overview of customer expectations. In stage 2, results from an online survey among German consumers were analyzed. In general, customers expect a simplification of privacy statements and easier control options and are willing to switch to a competitor if it better fulfills expectations. Women and older respondents have higher expectations than men and younger respondents. A short field study of online retailing websites shows that companies are currently not fulfilling customer expectations. Managerial implications are derived to improve this situation.
Housing in Australia in the 2000s: On the Agenda Too Late?

During the 2000s, however, housing put itself on the agenda. Increased interest in housing was reflected in academic literature, in media commentary and in government and industry concerns. At the macroeconomic level, the start of the decade brought the chicken and egg problem of rising house prices and increasing housing debt. This raised concerns about the impact of increasing housing debt on macroeconomic stability and generated considerable analysis of wealth effects. Debates over whether policy in general, and monetary policy in particular, should respond to significant changes in asset prices followed. By the middle of the decade, the key macroeconomic debate turned to the issue of whether the unprecedented worldwide increase in house prices constituted a housing bubble. By the end of the decade, for much of the developed world the ‘bubble question’ had been answered (although not necessarily for Australia). Debates over central bank intervention, however, remained and the focus shifted to the role of housing and
Sequence Assignment Model for the Flight Conflict Resolution Problem

Each and every day, certain air route traffic control centers receive a large number of requested flight plans, each detailing the level, track, and entry time for the flight to enter the oceanic airspace. Because each airline independently optimizes its own flight plans, it is common that the requested flight plans result in an unbalanced usage of level and track capacities and a conflicting schedule that violates the Federal Aviation Administration (FAA) safety standards. In such a situation, the flight conflict resolution problem is to provide a schedule that minimizes the total penalty cost of delay, level change, and track change while maintaining the FAA separation standards. In this paper, we propose a flight sequence assignment model (FSAM) that selects an optimal set of flight sequences to minimize the total penalty cost. We develop a column generation framework with a bilinear pricing subproblem to solve the linear relaxation of the FSAM, and use a branch-and-price method to find the integer optimal solution. The proposed model is tested on 10 simulated instances randomly constructed based on a real data set. The results show that the FSAM outperforms all other methods in all test instances. We also extend the FSAM to incorporate equity of flight plans among airlines. The computational results show that the equity constraints marginally increase the overall schedule disruption.
Virus ( Mtv )-negative and Single-Mtv Mice to Evaluate the Effects o f Endogenous Viral Superantigens on the T Cell Repertoire

From the *Howard Hughes Medical Institute, l~'vision of Basic Immunology, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206; ~. Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195; and the w of lmmunolog~ and Medicine, and [IDepartment of Biochemistry, Biophysics, and Genetics, University of Colorado Health Sciences Center, Denver, Colorado 80262
A Workload Based Lookup Table for Minimal Power Operation Under Supply and Body Bias Control

Dynamic Voltage Scaling (DVS) and Adaptive body bias (ABB) techniques respectively try to reduce the dynamic and static power components of an integrated circuit. Ideally, the two techniques can be combined to find the optimal operating voltages (VDD and VBB) to minimize power consumption. A combination of the DVS and ABB may warrant the circuit to operate at voltages (supply and body bias) different from the values specified by the two methods working independently. Also, this VDD and VBB values for minimal power consumption varies with the workload of the circuit. The workload can be used as an index to select the optimal VDDNBB values to minimize the total power consumption. This paper examines the optimal voltages for minimal power operation for typical data path circuits like adders and multiply-accumulate (MAC) units across various process, voltage, and temperature conditions and under different workloads. In addition, a workload based look up table to minimize the power consumption is also proposed. Simulation results for an adder and a multiply-accumulate circuit block indicate a power saving of 12-30% over standard DVS scheme.
The Handbook of Child and Adolescent Clinical Psychology : A Contextual Approach

Frameworks for Practice. Normal Development. Influences on Problem Development. Classification, Epidemiology and Treatment Effectiveness. The Consultation Process and Intake Interviews. Report Writing. Problems of Infancy and Early Childhood. Sleep Problems. Toileting Problems. Learning and Communication Difficulties. Autism and Pervasive Developmental Disorders. Problems of Middle Childhood. Conduct Problems. Attention and Overactivity Problems. Fear and Anxiety Problems. Repetition Problems. Somatic Problems. Problems in Adolescence. Drug Abuse. Mood Problems. Anorexia and Bulimia Nervosa. Schizophrenia. Child Abuse. Physical Abuse. Emotional Abuse and Neglect. Sexual Abuse. Adjustment to Major Life Transitions. Foster Care. Separation and Divorce. Grief and Bereavement.
Study of a boost converter for PEM fuel cell

This work concerns the study and the modeling of a static converter step-up fuel cell, in order to understand the behavior of this type of energy source in power electronics. After an overview of its operation, this paper proposes a model fuel cell PEMFC supplied with pure hydrogen and oxygen. This model takes into account of the different physicochemical phenomena in a fuel cell. This paper presents a proposed model for a PEM fuel cell: the static model with undissociated electrodes which involves classical laws to describe the different phenomena in a stack. In essence, this model is directly implemented under Matlab-Simulink and can therefore be connected to the static converter model which is regulated in voltage; this model is used as a voltage source for the static converter. The type of the conversion structure is a boost, increasing the voltage delivered by the fuel cell and controlled by a PWM signal. After modeling the converter, it is connected to the fuel cell model. The control regulation system is then defined based on the use of a PID controller. Then, the system formed by the fuel cell and the converter is compared to that formed by the same converter but powered with single power-supplied with a classical generator battery.
On the Impact of Kanban on Software Project Work: An Empirical Case Study Investigation

The pertinent mission of software project management is to continuously achieve more and more successful projects. In the field of software development, the Kanban method has gained momentum recently, mostly due to its linkages to Lean thinking. However, only a few empirical studies investigate the dynamics and impacts of Kanban on projects. The aim of this study is to improve the understanding on how Kanban impacts on software project work. For the purpose of the study, a framework is developed and empirically investigated in an experimental software R&D setting called Software Factory. The impact of Kanban is evaluated from nine theoretically derived perspectives. The results highlight new findings regarding the application of Kanban in the software context. This bears managerial implications, which is addressed. The key implications of the findings suggest that Kanban and its inherent simplicity motivate the workers and control the project activities.
Unusual Integrase Gene Expression on the clc Genomic Island in Pseudomonas sp. Strain B13

ABSTRACT An unusual type of gene expression from an integrase promoter was found in cultures of the bacterium Pseudomonas sp. strain B13. The promoter controls expression of the intB13 integrase gene, which is present near the right end of a 105-kb conjugative genomic island (the clc element) encoding catabolism of aromatic compounds. The enzymatic activity of integrase IntB13 is essential for site-specific integration of the clc element into the bacterial host's chromosome. By creating transcription fusions between the intB13 promoter and the gfp gene, we showed that integrase expression in strain B13 was inducible under stationary-phase conditions but, strangely, occurred in only a small proportion of individual bacterial cells rather than equally in the whole population. Integrase expression was significantly stimulated by growing cultures on 3-chlorobenzoate. High cell density, heat shock, osmotic shock, UV irradiation, and treatment with alcohol did not result in measurable integrase expression. The occurrence of the excised form of the clc element and an increase in the rates of clc element transfer in conjugation experiments correlated with the observed induction of the intB13′-gfp fusion in stationary phase and in the presence of 3-chlorobenzoate. This suggested that activation of the intB13 promoter is the first step in stimulation of clc transfer. To our knowledge, this is the first report of a chlorinated compound's stimulating horizontal transfer of the genes encoding its very metabolism.
The Test of English as a Foreign Language

Investigates a scientific basis for establishing the Test of English as a Foreign Language (TOEFL) cut‐off scores. Obtains data on 348 foreign students from 50 US universities. Divides students into three categories according to TOEFL score: below 550; 550‐600; and above 600. Measures academic success by first semester or quarter grade point average (GPA) score. Finds a significant difference in GPA score between international graduate students with TOEFL scores above 550 when compared with those with scores below 550. Results support the national trend towards raising foreign graduate student admission minimum TOEFL scores from 500 to 550.
Comparative comprehensive statistical modeling in different stage of blood pressure based on high density lipoprotein cholesterol level

Atherosclerosis is a condition when the arteries become narrowed and hardened due to the excessive of plaque which is made of fat, cholesterol, calcium and other substances. It is also known as arteriosclerotic vascular disease. The aims of this study were to examine the factors that are associated directly or indirectly with a triglycerides level in three distinct phases of blood pressure. We employed structural equation modeling (SEM) method in order to know the associated factors of triglycerides level in three distinct phases of blood pressure which are normal, borderline and hypertensive. The statistical analysis revealed that body mass index [(β = 0.924, p < 0.001), (β = 0.924, p < 0.001) and (β = 0.937, p < 0.001)], weight [(β = 0.962, p < 0.001), (β = 0.925, p < 0.001) and (β = 0.940, p < 0.001)] and hip circumference [(β = 0.903, p < 0.001), (β = 0.910, p < 0.001) and (β = 0.897, p < 0.001)] were statistically significant across the three distinct phases of blood pressure. This finding shows that the triglycerides might be a valuable marker of atherosclerosis in three distinct phases of blood pressure.
The AROUND project: Adapting robotic disaster response to developing countries

The global climate change induces an increase, in terms of frequency and devastating power, of natural disasters (particularly in developing countries). For facing this, there is a growing need for robotic assistance, for collecting information, managing disaster situation, rescuing victims and preserve human lives. It is one of the means recommended by the UNPD (United Nations Program for Development), which consist in the deployment of on-field automated monitoring, surveillance and reconnaissance systems. This paper outlines the research performed in the AROUND (autonomous robots for observation of urban networks after disasters) project. This project addresses the issue of developing a search and rescue multi-robot systems taking into account specific constraints of developing countries.
Replication Origins in XenopusEgg Extract Are 5–15 Kilobases Apart and Are Activated in Clusters That Fire at Different Times

When Xenopus eggs and egg extracts replicate DNA, replication origins are positioned randomly with respect to DNA sequence. However, a completely random distribution of origins would generate some unacceptably large interorigin distances. We have investigated the distribution of replication origins in Xenopus sperm nuclei replicating in Xenopus egg extract. Replicating DNA was labeled with [3H]thymidine or bromodeoxyuridine and the geometry of labeled sites on spread DNA was examined. Most origins were spaced 5–15 kb apart. This regular distribution provides an explanation for how complete chromosome replication can be ensured although origins are positioned randomly with respect to DNA sequence. Origins were grouped into small clusters (typically containing 5–10 replicons) that fired at approximately the same time, with different clusters being activated at different times in S phase. This suggests that a temporal program of origin firing similar to that seen in somatic cells also exists in the Xenopus embryo. When the quantity of origin recognition complexes (ORCs) on the chromatin was restricted, the average interorigin distance increased, and the number of origins in each cluster decreased. This suggests that the binding of ORCs to chromatin determines the regular spacing of origins in this system.
Functional pearl: implicit configurations--or, type classes reflect the values of types

The configurations problem is to propagate run-time preferences throughout a program, allowing multiple concurrent configuration sets to coexist safely under statically guaranteed separation. This problem is common in all software systems, but particularly acute in Haskell, where currently the most popular solution relies on unsafe operations and compiler pragmas.We solve the configurations problem in Haskell using only stable and widely implemented language features like the type-class system. In our approach, a term expression can refer to run-time configuration parameters as if they were compile-time constants in global scope. Besides supporting such intuitive term notation and statically guaranteeing separation, our solution also helps improve the program's performance by transparently dispatching to specialized code at run-time. We can propagate any type of configuration data-numbers, strings, IO actions, polymorphic functions, closures, and abstract data types. No previous approach to propagating configurations implicitly in any language provides the same static separation guarantees.The enabling technique behind our solution is to propagate values via types, with the help of polymorphic recursion and higher-rank polymorphism. The technique essentially emulates local type-class instance declarations while preserving coherence. Configuration parameters are propagated throughout the code implicitly as part of type inference rather than explicitly by the programmer. Our technique can be regarded as a portable, coherent, and intuitive alternative to implicit parameters. It motivates adding local instances to Haskell, with a restriction that salvages principal types.
Evaluation of Features for Sentence Extraction on Different Types of Corpora

We report evaluation results for our summarization system and analyze the resulting summarization data for three different types of corpora. To develop a robust summarization system, we have created a system based on sentence extraction and applied it to summarize Japanese and English newspaper articles, obtained some of the top results at two evaluation workshops. We have also created sentence extraction data from Japanese lectures and evaluated our system with these data. In addition to the evaluation results, we analyze the relationships between key sentences and the features used in sentence extraction. We find that discrete combinations of features match distributions of key sentences better than sequential combinations.
Response-Time Modeling for Resource Allocation and Energy-Informed SLAs

The growth of Internet datacenters is increasingly limited by their power consumption. Powering and cooling a datacenter now rivals the cost of the hardware: each $1 spent on servers in 2005 required an additional $0.48 to power and cool it, expected to rise to $0.71 by 2010 [4]. Techniques to scale down power consumption during periods of low workload are therefore desirable. However, datacenter operators also typically require a strong guarantee on the tail of the response-time distribution called a service-level agreement (SLA), such as that the 99th percentile of response times is less than 300 ms. Power management technology built in to current microprocessors includes techniques such as dynamic voltage and frequency scaling (DVFS), which dynamically reduces the CPU frequency during periods of low utilization. In actual datacenters, however, the built-in DVFS is almost never used, because conventional wisdom holds that its use leads to unpredictable service times. Indeed, this concern is justified, because built-in power management strategies are oblivious to the desired SLA, so they cannot increase resources when the desired performance objective is not met.
Explaining Friendship Formation and Friendship Stability: The Role of Children's and Friends' Aggression and Victimization

This study examined variation in friendship formation and friendship stability as a function of children's and their friends' victimization, overt aggression, and relational aggression. Participants were 605 pre- and early adolescents in fifth through eighth grades (M age = 12.05) assessed twice over a three-month period. Scores for stability and acquisition of same-sex reciprocated friendships were derived from unlimited friendship nominations. Peer nominations provided scores for child and friend victimization and aggression. Only victimized children experienced difficulty forming new friendships, evidence of their persistent social problems. Dissimilarity between friends on relational aggression (all children) and victimization (girls only) predicted friendship termination, however; overtly aggressive children had difficulty maintaining friendships regardless of their friends' aggression. These findings point to the importance of considering the relational context (characteristics of children and their friends) and gender when assessing friendship stability.
The Open University ’ s repository of research publications and other research outputs An empirical investigation of the emergent issues around OER adoption in Sub-Saharan Africa

Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online's data policy on reuse of materials please consult the policies page. Within the past few years, Africa has joined the rest of the world as an active participant in the Open Educational Resources (OER) movement with a number of home-grown and externally driven initiatives. These have the potential to make an immense contribution to teaching and learning in Sub Saharan Africa (SSA). However, certain barriers prevent full participation. This paper reports on qualitative research that sought to investigate SSA's readiness to adopt OER. The study involves three case studies based in higher education institutions involved in OER projects and located in Kenya, Uganda, and South Africa. Findings indicate contrary to popular belief that low technology levels in Africa do not necessarily impede adoption of such educational technologies; the real challenges facing readiness to adopt OER appear to be related to socioeconomic , cultural, institutional and national issues. This paper argues for a complete mind shift in how people perceive OER. It also proposes raising awareness of OER at all levels, involving institutions and government, versioning OER for the African context and conducting more research on OER adoption. Introduction When the concept of Open Educational Resources (OER) was conceived, supporters perceived it as a way of making knowledge accessible to all, especially those in most need (Smith & Casserly, 2006). This view is also shared by the 2002 Unesco Forum 1 on the impact of open courseware for developing countries. In their declaration, the forum participants expressed " their wish to develop together a universal educational resource available for the whole of humanity " (UNESCO, 2002 p. 6). Since then, great strides have been made to make the OER dream a reality all over the world. Ground breaking initiatives such as OpenLearn 2 , MIT OpenCourseWare 3 , UCT OpenContent 4 and MERLOT 5 now exist, making quality 2 educational content freely and openly available to anyone willing and able to use it. However, the fact that this notion of OER is foreign and was conceived and framed in the main within technologically-enabled contexts raises some fundamental issues that influence their effective adoption in developing countries. This paper reports findings from a qualitative investigation that explores Sub Saharan Africa (SSA)'s readiness to adopt OER …