Miracle-dz/UniFAR-FTUs huggingface dataset:
Congestion-Aware Dynamic Elevator Assignment for Partially Connected 3D-NoCs

The combination of Network-on-Chips (NoCs) and 3D IC technology, 3D NoCs, has been proven to be able to achieve a great improvement in both network performance and power consumption compared to 2D NoCs. In the traditional 3D NoC, all routers are vertically connected. Due to the large overhead of Through-Silicon-Via (TSV, e.g., low fabrication yield and the occupied silicon area), the partially connected 3D NoC has emerged. The assignment method determines the traffic loads of the vertical links (elevators), thus has a great impact on 3D-NoCs' performance. In this paper, we propose a congestion-aware dynamic elevator assignment (CDA) scheme, which takes both the distance factors and network congestion information into account. Experiments show that the performance of the proposed CDA scheme is improved by 67% to 87% compared to the random selection scheme, 8% to 25% compared to SelByDis-1, and 13% to 18% compared to SelByDis-2.
[Lateral spinal curvature measured among children and teenagers as a health problem of future employees].

BACKGROUND The aim of this study was to evaluate the location of primary lateral curvatures of the spine among children aged 12 to 15. MATERIALS AND METHODS A study group comprised 503 children aged 12 to 15, including 247 (49.11%) girls and 256 (50.89%) boys selected from Primary School No.13 and Secondary School No. 4 in Starachowice. The following parameters were recorded: average height--161.45 cm (girls) and 165.41 (boys); body mass--50.84 kg (girls) and 52.74 kg (boys); and BMI--19.43 (girls) and 19.08 (boys). The spatial photogrammetric method with use of projection chamber effect was applied in the study. RESULTS In the whole group, there were only 3 children (0.60%) with correct body posture. The majority of children showed thoracic curvatures (TH)--234 (46.80%), this was followed by lumbar curvatures (L)--170 (34.00%), and thoracic-lumbar curvatures (THL)--96 (19.20%). CONCLUSIONS Lateral spinal curvatures appear frequently. The study showed a strong relation between the location of primary curvature, gender (p < 0.001) and age (p < 0.001) of the examined children.
Biexponential model for predicting weight loss after gastric surgery for obesity.

BACKGROUND Following gastric restrictive surgery, morbidly obese patients rarely achieve their ideal body weight defined by Metropolitan Life tables. The final body weight will depend on the initial body composition because there will be greater weight loss from fat than lean body mass. The purpose of this study was to develop a mathematical model that accurately estimates the rate and extent of weight loss following gastric bypass surgery. METHODS Patients underwent gastric bypass followed by intensive medical therapy and serial bioelectrical impedance analysis (BIA) body composition measurements. Differential equations were derived to model weight loss. RESULTS Weight loss in the fat and lean body compartments followed monoexponential decay kinetics with differing rate constants. Total body weight loss (W(T)) at time t was W(T) = k(f)(k(f) - k(l)) (W(f(o))e(-k(f)t) + W(l(o))e(-k(l)t)), where W(fo) and W(lo) are the initial fat and lean body masses determined by BIA and k(f) and k(l) are the rate constants for the fat and lean compartments, respectively. Following surgically induced weight loss, k(f) = 7.61 +/- 1.27 x 10(-2), and k(l) = -0.93 +/- 0.13 x 10(-2), with the ratio of residual sum of the squares to the total sum of the squares of 98.8%. CONCLUSION Accurate prediction of weight loss depends on the initial fat and lean compartment mass since each of these loses weight at a different rate and to a different extent. When these effects are accounted for, the total body weight loss can be accurately predicted for any given time following surgery.
Texture segmentation using filters with optimized energy separation

The design of filters for texture feature extraction is addressed. Based on a new feature extraction model, optimization approaches utilizing various feature (energy) separation criteria are developed. Both two- and multiple-texture problems are addressed. The approaches are assessed by supervised segmentation experiments. The experiments also include results from alternative filter optimization approaches.
A computational simulation approach for optimising process parameters in cutting operations

The aim of this study was to determine the optimal parameters of cutting operations in order to obtain a minimised cost per unit time, with an acceptable quality level. The cost per unit for cutting operations is partly related to cutting time and tool life. The acceptable quality level is measured mainly in regard to surface roughness. The cutting time, tool life and surface roughness are all functions of cutting parameters. For cost and quality optimisation, in cutting parameter determination, an integration of three elements in problem formulation is necessary. However, with recent developments in computer hardware and software, the computer experimental approach consisting of both a computer simulation and a statistical method has become possible. With removal geometry configuration being specified, the computer simulation is performed by existing computer-aided engineering software, such as CATIA and Computer Cutting Data Service. The simulated outputs are analysed by statistical methods, such as response surface methodology, to obtain the predicted cutting time and tool life functions. These two functions will be further plugged into a unit cost model as the objective function, along with quality level as constraints. Then, the problem is formulated with mathematical programming to determine optimal cutting parameters for both quality and cost.
Expression levels of genes for ATP‐binding cassette transporters and sterol 27‐hydroxylase in liver and intestine of baboons with high and low cholesterolemic responses to dietary lipids

Abstract: Baboons with high and low lipemic responses to dietary lipids differ in intestinal cholesterol absorption and hepatic cholesterol metabolism. ATP‐binding cassette (ABC) transporters play an important role in cholesterol absorption and hepatic cholesterol metabolism. Using frozen tissues from high‐ and low‐responding baboons maintained on the cholesterol and fat‐enriched diet, we determined the relative expression of ABCA1, ABCG5, ABCG8, and 27‐hydroxylase genes in the liver and intestine using TaqMan® real‐time polymerase chain reaction. There was no consistent difference in the expression of ABC‐transporters and 27‐hydroxylase in the intestine between high‐ and low‐responding baboons. However, hepatic expression of sterol 27‐hydroxylase, ABCG5, and ABCG8 was higher in low‐responding baboons than in high‐responding baboons. There was also a significant correlation between the expression of sterol 27‐hydroxylase and ABCG5, and ABCG8 in both the liver and the intestine. These results suggest that differences in hepatic lipid metabolism but not in cholesterol absorption between high‐ and low‐responding baboons observed previously may be mediated by the differences in the expression levels of 27‐hydroxylase, ABCG5, and ABCG8.
Calculating Cooking Recipe's Difficulty based on Cooking Activities

In recent years, there have been plenty of cooking recipes on the internet. Because it has caused difficulty in searching for a cooking recipe that suites one's needs, many studies have researched on how to make these recipes easily accessible. Existing studies have focused on the components of cooking recipes, such as ingredients, nutrients, and condiments. However, if the recipe contains difficult cooking activities for the user, the user may not be able to cook the dish according to the recipe. Consequently, it is necessary to match the searched recipe's cooking skills. Therefore, in this work, we define four-levels of difficulty of cooking activities, and we propose a method for calculating a cooking recipe's difficulty level when searching for one that matches a user's cooking skills. Then, our approach was evaluated using a questionnaire survey on a crowdsourcing site. The results of our experiment showed that our approach can reduce the burden on users when searching for appropriate cooking recipes.
Prediction model based on improved particle swarm optimization algorithm analysis and its application scenario building

Aimed at the very nonlinear and vulnerability of differing cost of building changes, another technique for differing cost of building destruction in view of Enhanced Particle Swarm Optimization (EPSO) back propagation has been proposed. By presenting transformation operation and versatile modify of dormancy weight, the issue of simple to fall into neighborhood ideal, untimely, low exactness and low later interation effectiveness of Particle Swarm Optimization are comprehended. By utilizing the Enhanced Particle Swarm Optimization to streamline Back Propagation neural network's parameters, the learning rate and optimization capacity of traditional Back Propagation are adequately moved forward. At that point the versatile molecule swarm optimization calculation taking into account cloud hypothesis was utilized to improve the weights and edges of wavelet Back propagation neural network, Instead of customary inclination drop strategy. The reproduction aftereffects of differing cost of building expectation demonstrate that the anticipate exactness of the new strategy is altogether higher than that of ordinary Back Propagation neural network and wavelet neural network technique. What's more, the technique is viable and attainable.
The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control

Here, we show that the budding yeast proteins Ndc80p, Nuf2p, Spc24p and Spc25p interact at the kinetochore. Consistently, Ndc80p, Nuf2p, Spc24p and Spc25p associate with centromere DNA in chromatin immunoprecipitation experiments, and SPC24 interacts genetically with MCM21 encoding a kinetochore component. Moreover, although conditional lethal spc24‐2 and spc25‐7 cells form a mitotic spindle, the kinetochores remain in the mother cell body and fail to segregate the chromosomes. Despite this defect in chromosome segregation, spc24‐2 and spc25‐7 cells do not arrest in metaphase in response to checkpoint control. Furthermore, spc24‐2 cells showed a mitotic checkpoint defect when microtubules were depolymerized with nocodazole, indicating that Spc24p has a function in checkpoint control. Since Ndc80p, Nuf2p and Spc24p are conserved proteins, it is likely that similar complexes are part of the kinetochore in other organisms.
Effect of ketoconazole on the pharmacokinetics and safety of telithromycin and clarithromycin in older subjects with renal impairment.

OBJECTIVE The objective of this study was to determine the effect of multiple impairments in drug elimination on the pharmacokinetics and pharmacodynamics (effect on QTc interval), using clarithromycin as a comparator. METHODS Thirty-two subjects aged > or = 60 years with renal impairment who were otherwise medically stable were recruited into this parallel-group study. Following stratification according to creatinine clearance (CL(CR)), subjects were randomized to a five-day treatment with ketoconazole (400 mg once daily) alone, or a five-day treatment with ketoconazole (400 mg once daily) and telithromycin (800 mg once daily) given concomitantly or a five-day treatment with ketoconazole (400 mg once daily) and clarithromycin (500 mg twice daily) given concomitantly. Steady-state pharmacokinetics and safety, including serial electrocardiograms, were assessed. RESULTS In subjects with CL(CR) 30 - 80 ml/min, the mean maximal telithromycin concentration at steady state (C(max),ss) was 3.6 mg/l and the steady state area under the plasma concentration-time curve from time zero to 24 hours (AUC(0-24 h) ss) was 33.4 mg x h/l. The mean C(max), ss and AUC(0-12 h)ss for clarithromycin were 6.2 mg/l and 56.1 mg x h/l, respectively. The increases in telithromycin C(max) ss and AUC(0-24 h) ss compared to corresponding data for healthy young subjects were 1.6- and 2.7-fold, respectively, whereas corresponding increases for clarithromycin were 2.2- and 3.3-fold, respectively. In the telithromycin plus ketoconazole group deltaQTc values were equal or < 60 ms. All QTc values were equal or < 450 ms in males and equal or < 470 ms in females. CONCLUSIONS The increase in telithromycin plasma concentrations during ketoconazole-mediated inhibition of CYP3A4 in subjects aged 60 years or older with renal impairment was similar to that for clarithromycin under the same conditions. Telithromycin was well tolerated and produced no clinically significant prolongations in the QTc interval.
The utility of fractal analysis in clinical neuroscience

Abstract Physicians and scientists can use fractal analysis as a tool to objectively quantify complex patterns found in neuroscience and neurology. Fractal analysis has the potential to allow physicians to make predictions about clinical outcomes, categorize pathological states, and eventually generate diagnoses. In this review, we categorize and analyze the applications of fractal theory in neuroscience found in the literature. We discuss how fractals are applied and what evidence exists for fractal analysis in neurodegeneration, neoplasm, neurodevelopment, neurophysiology, epilepsy, neuropharmacology, and cell morphology. The goal of this review is to introduce the medical community to the utility of applying fractal theory in clinical neuroscience.
Recommended Approach to a NASPInet Architecture

NASPI is a collaborative effort between the U.S. Department of Energy (DOE), the North American Electric Reliability Corporation (NERC), and North American electric utilities, vendors, consultants, federal and private researchers and academics. NASPInet is an effort to develop an "industrial grade", secure, standardized, distributed, and scalable data communications infrastructure to support synchrophasor applications in North America. This paper will present a recommended approach to a NASPInet architecture that leverages commonly available network features and industry standards.
Toll-like receptor homolog RP 105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis

Introduction RP105 is a Toll-like receptor homolog expressed on B cells, dendritic cells (DCs), and macrophages. We investigated the role of RP105 in the development of collageninduced arthritis (CIA). Methods CIA was induced in RP105-deficient DBA/1 mice and the incidence and arthritis index were analyzed. The cytokine production by spleen cells was determined. The functions of the DCs and regulatory T cells (Tregs) from RP105-deficient or control mice were determined by adding these cells to the lymph node cell culture. Arthritis was also induced by incomplete Freund's adjuvant (IFA) plus collagen or by injecting anticollagen antibody and lipopolysaccharide. Results RP105-deficient mice showed accelerated onset of arthritis and increased severity. Interferon-gamma (IFN-γ) and tumor necrosis factor-alpha production by spleen cells from RP105-deficient mice was increased in comparison with that from wild-type mice. The DCs from RP105-deficient mice induced more IFN-γ production, whereas Tregs from those mice showed less inhibitory effect against IFN-γ production. RP105deficient mice also showed more severe arthritis induced by collagen with IFA. Conclusions These results indicate that RP105 regulates the antigen-presenting cell function and Treg development, which induced the attenuation of the cell-mediated immune responses and, as a result, suppressed the development of CIA. Introduction The Toll-like receptor (TLR) family is composed of pattern recognition receptors that recognize the pathogen-associated molecular patterns of microorganisms and trigger an innate immune response [1]. The TLRs are expressed mainly on macrophages and dendritic cells (DCs) and activate these cells after binding to their ligands. The activation of TLRs has been shown to induce proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1), and also to cause the upregulation of costimulatory molecules which activates the adaptive immune system [2,3]. Whereas the TLRs play a key role for host defense, they also play important roles in inflammatory diseases [4]. Rheumatoid arthritis (RA) is a chronic autoimmune and inflammatory disease characterized by synovial inflammation and destruction of cartilage and bone. Recently, TLRs have been shown to play an important role in arthritis both in humans and in experimental animal models. In RA, it has been shown that TLR2, TLR3, TLR4, and TLR7 are upregulated in the synovium and synovial macrophages [5-9]. Some of these TLRs are upregulated by proinflammatory cytokines and, in turn, have a costimulatory function [7,8]. The endogenous ligands of TLRs, such as heat shock proteins [10-12], hyaluronan [13,14], or degradation product of fibrinogen [15], are expressed in joints, and it is
A Power Sharing Control Scheme with Fast-Dynamic Response for Input-Series Output-Parallel DAB dc-dc Converter

With some advantages such as electric isolation, high efficiency and fast dynamic response, the input-series output-parallel (ISOP) DAB dc-dc converter has been regarded as one of the most promising candidates for connecting the medium voltage terminal and the low voltage terminal. In this paper, the average model of the ISOP DAB dc-dc converter is presented firstly, which can be employed to analyze the power distributions of this modular topology clearly. Then, the inherent coupling between the adjustment of input voltages for different power sharing performance and the adjustment of output voltages for fast-dynamic response is discussed. Moreover, for the ISOP DAB dc-dc converter system, a power sharing control scheme with fast-dynamic response is proposed for ensuring the power sharing ability and the fast-dynamic performance. Compared with existing methods, this proposed scheme can also significantly reduce the coupling between the power sharing control and the output voltage regulation. Finally, experiment results are provided to verify the effectiveness of the proposed power sharing control with fast-dynamic response for the ISOP DAB dc-dc converter system.
Cloning and expression of beta1,4-galactosyltransferase gene from Helicobacter pylori.

Helicobacter pylori, which is a human pathogen associated with gastric and duodenal ulcer, has been shown to express human oncofetal antigens Lewis X and Lewis Y. Although the mammalian glycosyltransferases that synthesize these structures are well characterized, little is known about the corresponding bacterial enzymes. We report that a novel beta1,4-galactosyltransferase gene (HpgalT) involved in the biosynthesis of lipopolysaccharides in H. pylori has been cloned and expressed in Escherichia coli. The deduced amino acid sequence of the protein (HpGal-T) encoded by HpgalT consists of 274 residues with the calculated molecular mass of 31,731 Da, which does not show significant similarity to those of beta1,4-galactosyltransferases from mammalian sources and Neisseria It was confirmed that HpGal-T catalyzed the introduction of galactose from UDP-Gal in a beta1,4 linkage to accepting N-acetylglucosamine (GlcNAc) residues by means of high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD). When the E.coli cells which overexpressed HpgalT was coupled with the UDP-Gal production system, which consisted of recombinant E.coli cells overexpressing its UDP-Gal biosynthetic genes and Corynebacterium ammoniagenes, N-acetyllactosamine, a core structure of lipopolysaccharide of H.pylori, was efficiently produced from orotic acid, galactose, and GlcNAc.
Process development for the enrichment of curcuminoids in turmeric spent oleoresin and its inhibitory potential against LDL oxidation and angiotensin-converting enzyme

Turmeric (Curcuma longa) contains biologically active colouring constituents, curcuminoids, which are isolated from the turmeric rhizome by solvent extraction. The mother liquor left after the separation of curcuminoids is known as turmeric spent oleoresin (SOT). The present study developed a method for the enrichment of curcuminoids in SOT. By using this method, curcuminoids in the SOT (8.4%) were doubled (17.5%). Presence of curcuminoids in enriched fraction was confirmed by high performance liquid chromatography (HPLC) and liquid chromatography coupled with mass spectroscopy analysis. Further studies on this fraction showed that it can effectively inhibit angiotensin-converting enzyme and low-density lipoprotein oxidation with IC50 values of 19.45 μg/ml and 30.52 μg/ml, respectively. The results showed that curcuminoids enriched fraction (CEF) can reduce the risk of hypertension and cardiovascular diseases. In addition to this fraction, a turmerone-rich hexane fraction was also separated from the spent oleoresin.
Taux de change réel d’équilibre et fardeau de la dette en Afrique Subsaharienne

The main purpose of this paper is to demonstrate the effect of debt overhang on real equilibrium exchange rate. Using a panel of twenty Sub-Saharan African countries, we find a non linear effect of external public debt on real exchange rate. External public debt negatively affects the real exchange rate up to about 90% and 100% of GDP. This result is supported by panel unit root test and panel co integration test. The main surplus of this paper is to show a non linear effect of debt on real exchange rates in African countries.
A frequency diversity process for speckle reduction in real-time ultrasonic images

A pair of concurrent real-time B-mode image lines has been formed using a parallel processing system. In this system a wideband received echo is partitioned by a frequency diversity process and separate image lines are formed. Due to their differing constituent frequencies, these image lines have decorrelated speckle patterns. Upon averaging these filtered lines, the amount of speckle in the resultant displayed image is reduced. The reduction in image speckle and its accompanying improvement in perceived resolution is accomplished with no sacrifice of temporal resolution or real-time format. The effects of filter separation and filter quality factor (Q) are investigated through statistical analysis of images containing speckle-producing targets. A measurable improvement in image signal-to-noise ratio has been achieved. <<ETX>>
Measurement of fiber orientation distributions using high angular resolution diffusion imaging

High angular resolution measurements of diffusion are used to estimate the angular distribution and diffusion anisotropy of fibers in a voxel. A simple, axially symmetric model of diffusion in white matter fibers is used to relate diffusion measurements to fiber properties. The new technique is called fiber orientation estimated using continuous axially symmetric tensors (FORECAST). It is tested using both numerical simulation and in vivo measurements. The new method agrees with other methods in voxels containing single fibers, but resolves crossing fibers better, at least at the level of diffusion weighting used in this study (tr(b) = 1480 s/mm2). The simplifying assumptions of the model are tested by comparison with the “model‐free” q‐ball analysis of in vivo data and the results are shown to be in good agreement. The new method addresses the problem of partial volume averaging in diffusion tensor imaging and provides a basis for more reliable estimates of fiber orientation and fractional anisotropy. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.