Miracle-dz/UniFAR-FTUs huggingface dataset:
Monitoring and Diagnostics with Intelligent Agents Using Fuzzy Logic

Intelligent Agents have originated a lot of discussion about what they are, and how they are different from general programs. We describe in this paper a new paradigm for intelligent agents. This paradigm helped us deal with failures in an independent and efficient way. We proposed three types of agents to treat the system in a hierarchical way. A new way to visualize fault tolerant systems (FTS) is proposed, with the incorporation of intelligent agents, as they grow and specialize create the Multi-Agent System (MAS). The MAS contains a diversified range of agents, which depending on the perspective will be specialized or evolutionary (from our initially proposal) they will be specialized for the detection and possible solution of errors that appear in an FTS). The initial structure of the agent is proposed in (1) and named reflected agent with an internal state and in the Method MeCSMA (2). The present work is based on the idea that with the help of the paradigm of intelligent agents, we may be able to handle fault tolerant systems, in the modality of embedded systems. The idea is to detect errors and to try to correct the failures that could happen in industrial control by monitoring and diagnosis.
Geometry of fiber distribution in Marl yarn using the computational method

Abstract In this research, the structure of a type of bi-component composite yarns so called Marl yarn was studied. Fibers packing density factors within the yarn cross section as well as the effect of twisting on the resultant yarn were investigated. Samples of Marl acrylic yarns were provided using different twisting levels. Images of the cross sections of the produced yarn were obtained using the transverse sectioning method. The images were captured using the optical microscopy. The prepared images of the yarn cross section were then analyzed using image processing methods. In the first stage, yarn central coordinates and radiuses were calculated. In order to investigate the uniformity of fibers distribution and packing density within the yarn cross section, the fiber distances from the yarn center within the small radial and polar elements were calculated and the coefficient of variations (CV %) was determined. The maximum value of the fibers packing density was determined. The results showed that the fibers were mostly concentrated within the central region of the yarn; this was followed by the decrease in the fibers packing density while moving into the yarn’s outer layers. It was also concluded that increasing the intensity of the applied twist would result in higher fibers packing as well as the decrease in the yarn radius.
Prion protein expression and the M129V polymorphism of the PRNP gene in patients with colorectal cancer

The prion protein, PrPC, is known mostly for its involvement in neurodegenerative spongiform encephalopathies. However, a role for this molecule in cancer is becoming increasingly recognized partly because it promotes cell proliferation and inhibits apoptosis. Moreover, the codon 129 polymorphism (M129V) of the PRNP gene (the PrPC‐encoding gene) has been associated with neurodegenerative disease development and severity, while no information is available regarding its role in colorectal cancer (CRC) incidence and disease progression. We have previously reported that expression levels of PRNP may have a prognostic value in CRC, suggesting a role for the prion protein in CRC. The aim of this study was to investigate retrospectively the possible role of M129V and PrPC expression in patients with CRC. The M129V single nucleotide polymorphism was genotyped by real time polymerase chain reactions in 110 patients with CRC and 124 healthy donors. Moreover, protein expression was assessed by immunohistochemistry in 68 patients with CRC. Allele frequencies were similar in patients and healthy controls indicating that the M129V polymorphism is not a risk factor for CRC. Furthermore, it did not correlate with any clinicopathological parameters. By contrast, PrPC expression was highly elevated in neoplastic compared to normal tissue and differed depending on the primary site. Interestingly, protein levels were correlated with disease recurrence (P = 0.007). Conclusively, PrPC overexpression may constitute a prognostic marker for disease recurrence and potentially a new target for anticancer therapy. However, further studies are needed to evaluate prospectively the role of PrPC expression in patients with CRC. © 2010 Wiley‐Liss, Inc.
Emergent synchrony in locally coupled neural oscillators

The discovery of long range synchronous oscillations in the visual cortex has triggered much interest in understanding the underlying neural mechanisms and in exploring possible applications of neural oscillations. Many neural models thus proposed end up relying on global connections, leading to the question of whether lateral connections alone can produce remote synchronization. With a formulation different from frequently used phase models, we find that locally coupled neural oscillators can yield global synchrony. The model employs a previously suggested mechanism that the efficacy of the connections is allowed to change on a fast time scale. Based on the known connectivity of the visual cortex, the model outputs closely resemble the experimental findings. Furthermore, we illustrate the potential of locally connected oscillator networks in perceptual grouping and pattern segmentation, which seems missing in globally connected ones.
Blastocysts derivation from somatic cell fusion with premature oocytes (prematuration somatic cell fusion)

This study was undertaken to investigate the development of immature oocytes after their fusion with male somatic cells expressing red fluorescence protein (RFP). RFP‐expressing cells were fused with immature oocytes, matured in vitro and then parthenogenetically activated. Somatic nuclei showed spindle formation, 1st polar body extrusion after in vitro maturation and protruded the 2nd polar body after parthenogenetic activation. RFP was expressed in the resultant embryos; two‐cell stage and blastocysts. Chromosomal analysis showed aneuploidy in 81.82% of the resulting blastocysts while 18.18% of the resulting blastocysts were diploid. Among eight RFP‐expressing blastocysts, Xist mRNAs was detected in six while Sry mRNA was detected in only one blastocyst. We propose “prematuration somatic cell fusion” as an approach to generate embryos using somatic cells instead of spermatozoa. The current approach, if improved, would assist production of embryos for couples where the male partner is sterile, however, genetic and chromosomal analysis of the resultant embryos are required before transfer to the mothers.
Colonization and infection with Enterococcus faecalis in intensive care units: the role of antimicrobial agents

We studied the influences of antimicrobial agents on the colonization of the respiratory tract and infection with Enterococcus faecalis in intensive care unit (ICU) patients receiving mechanical respiration for at least 3 days. In a matched-cohort analysis, patients receiving topical antimicrobial prophylaxis (TAP) of the oropharynx and stomach with antimicrobial agents not treating E. faecalis were compared with patients not receiving TAP. Patients were matched with controls on the basis of their duration in the ICU, their use of systemic antibiotics treating and not treating E. faecalis, the administration of TAP, their APACHE II score, and surgical procedures they had undergone. In all, 276 patients were analyzed. The colonization of the oropharynx and/or trachea by E. faecalis at admission was demonstrated for 43 patients (16%). Twenty patients (9%) acquired tracheal colonization and 91 patients (40%) acquired oropharyngeal colonization with E. faecalis. In the matched-cohort analysis, 43 patients receiving TAP were matched in two controls each. TAP patients more frequently acquired tracheal colonization (15 of 43 versus 2 of 86 patients, P < 0.00001) and infections with E. faecalis (6 of 43 versus 1 of 86 patients, P < 0.01). The use of topical antibiotics and treating E. faecalis increased the risk for colonization and infection with E. faecalis.
On compacting test sets by addition and removal of test vectors

This paper presents a method of test compaction for stuck-at faults in combinational circuits, that complements previously proposed methods and allows further reduction in test set size in a cost-effective way. A given test set is compacted by generating additional test vectors. Each test vector added allows the removal of two or more test vectors from the existing test set, thus reducing its size. Experimental results for benchmark circuits demonstrate the effectiveness of the method. <<ETX>>
Nearest neighbour based social recommendation using heat diffusion

Growth of the internet has lead to information overload. Recommender systems filter this vast amount of information and outputs useful information. They are traditionally based on users rating of items. But those systems were not useful for coldstart users i.e. users who have made very few purchases. So social recommenders began to evolve which makes use of social networks to improve recommendations. In this paper we propose a nearest neighbour based top N recommendation technique using social network. We model the data sources as graph and use heat diffusion process for generating recommendations. The experimental evaluation on the epinions dataset shows that our approach outperforms the approach that combines user based collaborative filtering approach and trust based approach.
The Investigation of Nanowires Properties in the Process of Deformation

In this work, the authors attempted to consider the influence of the geometry of the crystal lattice on the properties of nanowires, which manifest themselves in the process of uni-axial stretching. This work summarizes and systematizes the results of previous studies of the authors. The first group of samples – are typical FCC metal – Ni3Al. For these nanowires, deformation processes in directions with different packing densities of atoms <100>, <110> and <111> were investigated. The second material group studied was an alloy with the non-cubic symmetry of the element cell CuAu I. Correspondingly, this sample was examined under deformation in directions corresponding to different lengths of the sides of the unit cell, <001> and <010>. All the investigations described in this paper were carried out by molecular dynamics method on three-dimensional models using the Morse's pair potentials.
Vaccinia virus strains use distinct forms of macropinocytosis for host-cell entry

To enter host cells, vaccinia virus, a prototype poxvirus, can induce transient macropinocytosis followed by endocytic internalization and penetration through the limiting membrane of pinosomes by membrane fusion. Although mature virions (MVs) of the Western reserve (WR) strain do this in HeLa cells by activating transient plasma membrane blebbing, MVs from the International Health Department-J strain were found to induce rapid formation (and lengthening) of filopodia. When the signaling pathways underlying these responses were compared, differences were observed at the level of Rho GTPases. Key to the filopodial formation was the virus-induced activation of Cdc42, and for the blebbing response the activation of Rac1. In addition, unlike WR, International Health Department-J MVs did not rely on genistein-sensitive tyrosine kinase and PI(3)K activities. Only WR MVs had membrane fusion activity at low pH. Inhibitor profiling showed that MVs from both strains entered cells by macropinocytosis and that this was induced by virion-exposed phosphatidylserine. Both MVs relied on the activation of epidermal growth factor receptor, on serine/threonine kinases, protein kinase C, and p21-activated kinase 1. The results showed that different strains of the same virus can elicit dramatically different responses in host cells during entry, and that different macropinocytic mechanisms are possible in the same cell line through subtle differences in the activating ligand.
Resistance heating forming process based on carbon fiber veil for continuous glass fiber reinforced polypropylene

This paper successfully developed a resistance heating method based on carbon fiber thin veil for molding continuous glass fiber reinforced polypropylene composite. Electrical resistance, temperature distribution, and heating response of carbon fiber veil were investigated to evaluate its resistance heating behavior. One layer of carbon fiber veil with about 0.1 mm thickness was sandwiched by prepreg stacks with about 2 mm thickness and composite plate was fabricated through resistance heating and forming process. Void content, glass fiber distribution, and thickness of composite plate were obtained to evaluate forming quality. Flexural test was employed for mechanical assessment. The results shows that carbon fiber veil coupled with copper foil is an effective heating element with uniform temperature distribution and quick heating response, and the processing quality of composite plate is comparable to that using oven heating process. The feasibility of secondary resistance heating of composite plate based on carbon fiber veil was also demonstrated and the results indicate that composite plate containing carbon fiber veil can be molded into composite product using resistance self-heating process.
Reliability, repeatability and reproducibility: analysis of measurement errors in continuous variables

Clinical practice involves measuring quantities for a variety of purposes, such as aiding diagnosis, predicting future patient outcomes, and serving as endpoints in studies or randomized trials. Measurements are almost always prone to various sorts of errors, which cause the measured value to differ from the true value; accordingly, studies investigating measurement error frequently appear in this and other journals. The importance of measurement error depends upon the context in which the measurements in question are to be used. For example, a certain degree of measurement error may be acceptable if measurements are to be used as an outcome in a comparative study such as a clinical trial, but the same measurement errors may be unacceptably large to make measurements usable in individual patient management, such as screening or risk prediction. In the past 20 years many papers have been published advocating how studies of measurement error should be analyzed, with a paper by Bland and Altman1 being one of the most cited and well known examples. There has been much controversy concerning the choice of parameter to be estimated and reported, and consequently confusion surrounding the meaning and interpretation of results from studies investigating measurement error. In this paper we first distinguish between the general concepts of agreement and reliability to aid researchers in considering which are relevant for their particular application. We then review the statistical methods that can be used to investigate and quantify agreement and reliability, dealing separately with the different types of measurement error study, while emphasizing the largely common techniques that should be used for data analysis. We reiterate that the judgment of whether agreement or reliability are acceptable must be related to the clinical application, and cannot be proven by a statistical test. We highlight the fact that reliability depends on the population in which measurements are made, and not just on the measurement errors of the measurement method. We discuss the advantages of method comparison studies making at least two measurements with each measurement method on each subject. A key advantage is that the cause of a correlation between paired differences and means in the so-called Bland–Altman plot can be determined, in contrast to when only a single measurement is made with each method. Throughout the paper, we try to emphasize that calculated values of agreement and reliability from measurement error studies are estimates of parameters, and as such we should report such estimates with CIs to indicate the uncertainty with which they have been estimated. We restrict our attention to measurements of a continuous quantity; alternative methods are required for categorical data2.
Effects of External Potassium and Strophanthidin on Sodium Fluxes in Frog Striated Muscle

Unidirectional Na fluxes in isolated fibers from the frog's semitendinosus muscle were measured in the presence of strophanthidin and increased external potassium ion concentrations. Strophanthidin at a concentration of 10-5 M inhibited about 80 per cent of the resting Na efflux without having any detectable effect on the resting Na influx. From this it is concluded that the major portion of the resting Na efflux is caused by active transport processes. External potassium concentrations from 2.5 to 7.5 mM had little effect on resting Na efflux. Above 7.5 mM and up to 15 mM external K, the Na efflux was markedly stimulated; with 15 mM K the Na influx was 250 to 300 per cent greater than normal. On the other hand, Na influx was unchanged with 15 mM K. The stimulated Na efflux with the higher concentrations was not appreciably reduced when choline or Li was substituted for external Na, but was completely inhibited by 10-5 M strophanthidin. From these findings it is concluded that the active transport of Na is stimulated by the higher concentrations of K. It is postulated that this effect on the Na "pump" is produced as a result of the depolarization of the muscle membranes and is related to the increased metabolism and heat production found under conditions of high external K.
Graphene: promises, facts, opportunities, and challenges in nanomedicine.

Nanomedicine Hong Ying Mao,† Sophie Laurent,‡ Wei Chen,*,†,§ Omid Akhavan, Mohammad Imani, Ali Akbar Ashkarran, and Morteza Mahmoudi* †Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore ‡Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau, 19, B-7000 Mons, Belgium Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, Singapore Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran Institute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box 14588-89694, Tehran, Iran Novel Drug Delivery Systems Department, Iran Polymer and Petrochemical Institute, Tehran, Iran Department of Physics, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
IP route lookups as string matching

An IP route lookup can be considered as a string matching problem on the destination address. Finite state automata (FSA) are a flexible and efficient way to match strings. This paper describes how a routing table can be encoded as an FSA and how, through a process of state reduction, we can obtain an optimal representation. This gives insights into the basic properties of the longest-prefix match problem.
Nano-Desorption Electrospray and Kinetic Method in Chiral Analysis of Drugs in Whole Human Blood Samples

A home-made nano-desorption electrospray ionization (nano-DESI) device and the kinetic method were tested in chiral analysis of model clinical samples containing enantiomers of one of three pharmaceutically important compounds: dihydroxyphenylalanine (DOPA), ephedrine and ibuprofen. The initial evaluation of chiral systems was carried out by direct infusion of solution mixtures (analyte/central metal/chiral reference ligand) to a standard electrospray ionization (ESI) source. Cu(II) was used as a central metal for all analytes, l-phenylalanine was applied as a chiral reference ligand for DOPA, whereas l-tryptophan was used for the other two analytes. Then, the ESI source was substituted by a nano-DESI source and dried spots of 1 μL samples of whole human blood spiked with individual drugs were successfully analyzed without any pre-treatment. Irrespective of a laborious initial nano-DESI set-up, the combination of the kinetic method with nano-desorption electrospray has, for the first time, been demonstrated as a promising tool for chiral analysis of drugs in blood samples.
Pharmacological Treatment for Overactive Bladder in Women

Urinary incontinence is a common and distressing condition that is known to adversely affect quality of life. Overactive bladder is the term used to describe the symptom complex of urinary frequency and urgency, with or without urge incontinence. Drug therapy, in addition to behavioral modification, remains integral in the management of women with overactive bladder, and the development of new drugs, treatment regimens and methods of delivery should improve patient compliance and acceptability. This article critically reviews the current pharmacological treatment of overactive bladder in addition to providing a rationale for treatment.
Characterization of Coronary Atherosclerosis by Magnetic Resonance Imaging

Coronary atherosclerosis remains the major cause of mortality in industrialized and developing nations.1 Clinical risk-scoring systems do not allow satisfactory identification of individuals with subclinical disease and at high risk for coronary events.2 Novel approaches to more reliably identify asymptomatic individuals at high risk for future cardiovascular events are therefore urgently needed. Subclinical atherosclerosis may precede the development of clinical disease by many decades, thereby offering the opportunity to target primary prevention therapies to those at highest risk.3 Because of its noninvasiveness, excellent soft-tissue contrast, and ability to visualize blood and the coronary vessel wall with and without contrast agents, magnetic resonance (MR) imaging (MRI) is a very promising imaging modality to assess coronary lumen integrity, plaque burden, and biological plaque composition. Studies investigating subclinical and clinical coronary atherosclerosis have included non–contrast-enhanced (NCE) and contrast-enhanced (CE) coronary vessel wall cardiovascular MR (CMR). Recent studies have shown that noninvasive MR angiography allows the assessment of the presence or absence of >50% coronary artery stenosis with a diagnostic accuracy comparable to that of multidetector computer tomography if performed in a head-to-head comparison and with similar pharmacological preparation.4,5 Technical improvements in coil design, image acquisition and reconstruction, and motion compensation have allowed shortening the total imaging time of whole-heart coronary MR angiography to ≈5 minutes while maintaining good diagnostic accuracy.6–8 Several single-center and multicenter trials have demonstrated the potential of this technique compared with both x-ray coronary angiography and multidetector computer tomography.4,9,10 Direct assessment of the coronary vessel wall thickness and remodeling has been demonstrated with NCE-CMR in patients with subclinical coronary artery disease, in patients with type 1 diabetes mellitus, and in a multiethnic population (Multi-Ethnic Study of Atherosclerosis [MESA]) cohort.11–13 Additionally, NCE-CMR has been …