Miracle-dz/UniFAR-FTUs huggingface dataset:
Are metropolitan planning frameworks healthy? The case of Melbourne 2030

This paper presents preliminary findings of a project investigating the integration and application of ecological public health principles in Melboume 2030 , the Victorian Government's urban planning blueprint for Melboume for the next 30 years. The study examines the political, organisational, social, and inter-personal factors that impact on the integration and application of broad health considerations into urban planning policy in Victoria. We are testing the premise that achieving integrated planning requires a systematic integration of government activity across sectors. Using discourse analysis and key informant interviews, we examined relevant government policy and legislation and its implementation against world's best practice. Preliminary findings show that the degree of leadership in relation to deploying the mission, and implementation processes sustain or impede integrated planning at a whole-of-government and intersectoral level. These findings may inform a much-needed national agenda on promoting health through integrated planning. Findings will identify future research directions and action to bridge the gap between urban planning and health planning systems
Characteristics of Virulent, Attenuated, and Avirulent Mycoplasma pneumoniae Strains

Homologous pairs of virulent and attenuated or avirulent Mycoplasma pneumoniae strains were derived and compared in an effort to elucidate the mechanisms of virulence. These related strains were found to vary in growth, glycolysis, protein electrophoretic patterns, peroxide formation, morphology, and cytadsorption. Variations in the last two characteristics closely correlated with avirulence. This enables understanding of one stage in the pathogenic sequence and provides a convenient marker for avirulence. The derivation of infectious avirulent strains may make possible their use as live vaccines against M. pneumoniae disease.
Accelerated polarization reversal in a copolymer of vinylidene fluoride and trifluoroethylene

The ferroelectric switching time of a copolymer of vinylidene fluoride and trifluoroethylene depends on not only the applied electric field strength but also the history of the previous polarization process. Measurements using a bipolar on-off pulse field have shown that polarization reversal is accelerated as the pulse width is decreased. The rate of acceleration becomes more significant as the applied field strength is reduced. For a given pulse width, the switching time depends on the applied field according to an exponential law in that the activation field decreases with decreasing pulse width whereas the high-field-limit switching time remains constant. These results can be interpreted in terms of the nucleation probability that increases with decreasing on and/or off pulse width.
Localization of growth hormone receptor/binding protein messenger ribonucleic acid (mRNA) during rat fetal development: relationship to insulin-like growth factor-I mRNA.

Although GH plays a key role in postnatal growth, prenatal growth is thought to be GH independent. However, recent data has shown GH receptor/binding protein (GHR/BP) to be present in rat fetal tissues as early as fetal stage E12. The aim of the present study was to investigate tissue-specific production of the GHR/BP messenger RNA (mRNA) and its relationship to locally transcribed insulin-like growth factor-I (IGF-I) mRNA in the fetus. We have used in situ hybridization to localize GHR/BP and IGF-I mRNAs in 16.5-, 18.5-, and 20.5-day-old rat fetuses. Furthermore, because the two parameters of the IGF-I gene differentially respond to GH stimulation, we have also investigated the presence and localization of promoter-specific IGF-I mRNAs. We found the distribution of IGF-I and GHR/BP mRNAs to be widespread but distinct during the fetal stages examined. High levels of IGF-I mRNA were found in connective tissues or their precursors, including the dermis, perichondrium, and gut. In contrast, GHR/BP mRNA exhibited three distinct patterns of distribution. First, GHR/BP mRNA was found at epithelial sites adjacent to sites of IGF-I transcription. Second, GHR/BP and IGF-I mRNAs were found to colocalize in some connective tissues, but GHR/BP mRNA levels in these sites were often lower than at other sites (i.e. epithelial) of GHR/BP gene transcription. Third, GHR/BP mRNA was also found in regions remote from IGF-I mRNA, including the nerve ganglia and inner olfactory bulb. Using promoter-specific IGF-I RNA probes, we detected only promoter 1 transcripts in all fetal tissues examined. The only exception occurred in specialized epithelial cells of the cochlea where we detected high levels of both promoter 1- and 2-derived IGF-I transcripts. We have thus demonstrated a distinct distribution of GHR/BP and IGF-I mRNAs in the developing rat fetus with coordinate expression at some sites. These findings suggest a role of GH or a GH-like peptide, acting both directly and indirectly via IGF-I, in fetal growth and development.
Cloning of the netropsin resistance genes from Streptomyces flavopersicus NRRL 2820

Streptomyces flavopersicus NRRL 2820 (synonym: Streptomyces netropsis DSM40093) is resistant to the N‐methylpyrrole‐containing oligopeptide antibiotic netropsin. A 9.38 kb DNA‐fragment was isolated from a genomic library of Streptomyces flavopersicus using an Escherichia coli‐Streptomyces lividans shuttle vector which enables S. lividans to grow on netropsin‐containing agar plates. By subcloning, the resistance was conferred to a 5.9 kb Eco RV fragment. DNA sequence analysis of this Eco RV fragment revealed two open reading frames (netP1 , 1556 bp and netP2 , 1773 bp). The deduced proteins share significant similarity to each other (27% identity) and to the large family to ABC‐type multidrug resistance proteins. In each protein a conserved transmembrane and ATP binding domain was identified. Deletion analysis showed that both proteins are necessary for netropsin resistance indicating that the proteins form a heterodimeric ABC‐transporter exporting netropsin. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Incorporation of cholesterol in sphingomyelin- phosphatidylcholine vesicles has profound effects on detergent-induced phase transitions DOI 10.1194/jlr.M100355-JLR200

Vesicle ↔ micelle transitions are important phenomena during bile formation and intestinal lipid processing. The hepatocyte canalicular membrane outer leaflet contains appreciable amounts of phosphatidylcholine (PC) and sphingomyelin (SM), and both phospholipids are found in the human diet. Dietary SM enrichment inhibits intestinal cholesterol absorption. We therefore studied detergent-induced vesicle → micelle transitions in SM-PC vesicles. Phase transitions were evaluated by spectrophotometry and cryotransmission electron microscopy (cryo-TEM) after addition of taurocholate (3–7 mM) to SM-PC vesicles (4 mM phospholipid, SM/PC 40%/60%, without or with 1.6 mM cholesterol). After addition of excess (5–7 mM) taurocholate, SM-PC vesicles were more sensitive to micellization than PC vesicles. As shown by sequential cryo-TEM, addition of equimolar (4 mM) taurocholate to SM-PC vesicles induced formation of open vesicles, then (at the absorbance peak) fusion of bilayer fragments into large open structures (around 200 nm diameter) coexisting with some multilamellar or fused vesicles and thread-like micelles and, finally, transformation into an uniform picture with long thread-like micelles. Incorporation of cholesterol in the SM/PC bilayer changed initial vesicular shape from spherical into ellipsoid and profoundly increased detergent resistance. Disk-like micelles and multilamellar vesicles, and then extremely large vesicular structures, were observed by sequential cryo-TEM under these circumstances, with persistently increased absorbance values by spectrophotometry. These findings may be relevant for bile formation and intestinal lipid processing. Inhibition of intestinal cholesterol absorption by dietary SM enrichment may relate to high resistance against bile salt-induced micellization of intestinal lipids in presence of the sphingolipid.
A continuous quality improvement approach to IL-372 documentation compliance in an academic emergency department, and its impact on dictation costs, billing practices, and average patient length of stay.

OBJECTIVE To determine whether continuous quality improvement (CQI) methodology could improve and maintain IL-372 documentation compliance in an academic emergency department (ED). The impact on transcription costs, billing practices, and average patient length of stay was also analyzed. METHODS Baseline IL-372 compliance data were collected and shared with staff during a multidisciplinary educational session. Faculty dictation became mandatory. Pocket-sized dictation templates were provided. A Documentation Improvement Committee monitored outcomes. Each month of the study period, a compliance officer reviewed approximately 100 records. The following indicators were monitored: IL-372 compliance rates, dictation rates, transcription costs, down-coding rates, percentage of billable records, and average patient length of stay. Individualized results were provided to faculty. RESULTS During the ten-month study period, compliance rates increased from 60% to 100% (p-trend < 0.001), while dictation rates increased from 69% to 100% (p < 0.001). Rates of down-coding adjustments improved from 54% to 2% (p-trend < 0.001). The percentage of billable records increased from 65% to 100% (p-trend < 0.001). Transcription costs increased a modest 16%. The average patient length of stay remained unchanged. CONCLUSION The application of CQI methodology, combined with the availability of dictation, resulted in sustained improvement in IL-372 compliance. This was associated with a parallel increase in dictation rates, although concurrent transcription costs increased only modestly. The percentage of billable records increased, while the number of charts requiring down-coding decreased, both beneficial outcomes. Average length of stay was not adversely impacted by this added documentation requirement.
An analysis of media literacy skills among chinese sina weibo users

The purpose of this survey research is to examine the Chinese users’ media literacy skills gained before and after using Sina Weibo, and to examine the effect of their before-and-after usage of Sina Weibo on their media literacy skills. Two hundred Chinese Social Networking Service users of Sina Weibo were being selected by using random sampling to participant in the survey research. The mean and standard deviation were being analyzed by Paired Sample T-Test to examine the difference of media literacy skills before and after the usage of Sina Weibo. The findings revealed that Chinese Social Networking Service users gained significantly higher media literacy skills after using Sina Weibo than media literacy skills before using Sina Weibo. The respondents gained significantly access skills, analytical skills, evaluative skills, creative skills, and participative skills after using Sina Weibo.
An improved high level test synthesis algorithm

Genetic algorithm based high level test synthesis (HLTS) method is proposed, which can give consideration to testability in the course of various resource allocation. Its main feature lies in that it puts forward a novel chromosome coding method and designs corresponding genetic operation, thereby avoiding the generation of infeasible solution. Experimental results show the effectiveness of this method on testability.
Changes in proteomics profile during maturation of marrow‐derived dendritic cells treated with oxidized low‐density lipoprotein

Increasing evidence suggests that dendritic cells (DCs) and oxidized low‐density lipoprotein (ox‐LDL) participate in atherosclerosis. However, few data on the molecular mechanisms of this process are available. To address this question, we used iTRAQ labeling followed by LC‐MS/MS analysis to identify many proteins that changed markedly during the maturation of dendritic cells stimulated with ox‐LDL. Among a total of 781 identified proteins, 93 were upregulated and 100 were downregulated. The major and significant changes in upregulated proteins were that ox‐LDL not only affected the levels of intracellular cathepsins G, Z, D and S, but also significantly enhanced cathepsin S secretion by the treated cells. Our results may provide clues for a more comprehensive understanding the pathogenesis of atherosclerosis.
Adaptive architecture development for Smart Grids based on integrated building blocks

The development of ICT-Architectures for Smart Grids needs to regard requirements from multiple sources. These sources outline architectural viewpoints regarding domains, functionalities, and cross cutting issues like interoperability or security. A reference architecture is developed in context of the European Smart Grid Mandate M/490 which proposes a structure of interoperability layers, domains and zones, called the Smart Grid Architectural Model (SGAM). Such high-level reference architectures are not directly applicable within enterprises due to the differences in focus. Yet, the SGAM-structure may be used to transfer the concepts of the architecture into the enterprise context. For this purpose the methodological framework proposed in this contribution integrates the authors' research approaches. These provide integrated building blocks for enterprise-specific Smart Grid ICT-Architecture development, using the SGAM as the underlying structure.
Multicycle-aware At-speed Test Methodology

Multicycle paths are commonly seen in today's high performance designs with multi-frequency clock domains. Previous methods either treat the multicycle paths as false paths and masking the transition on the paths, or slow down the clocks in order to test the multicycle paths. Both approaches would compromise the at-speed test quality. In this paper, we present an at-speed test methodology to target the faults on the multicycle paths using the same clock scheme as regular faults at the single cycle paths. The methodology takes SDC files which defines all timing exceptions and the clock frequency information and create at-speed pattern set that detects faults on both single and multicycle paths. The approach also handles all of the timing exceptions and constraints defined in SDC to prevent simulation mismatches. The experiment results on couple industrial designs demonstrate the effectiveness and efficiency of the proposed methodology to handle complex designs with large timing exception paths.
Exercise aids, neighborhood safety, and physical activity in adolescents and parents.

PURPOSE To investigate the relationships among exercise aids available at home, physical activity, and perceived neighborhood safety. METHODS Physical activity was assessed using the 7-d recall interview for adolescents (n = 878) and the International Physical Activity Questionnaire for parents (n = 853). Parents reported exercise aids such as fitness equipment, running shoes, and dogs in their household using a 16-item checklist and perceptions of neighborhood safety using the Neighborhood Environment Walkability Scale. Physical activity scores were dichotomized to represent meeting weekly guidelines for children (300 min) and adults (150 min). Logistic regression analyses investigated the interaction between exercise equipment and neighborhood safety in relation to the two physical activity outcomes, controlling for participant demographics. RESULTS The number of home-use (OR = 1.27) and outdoor-use (OR = 1.24) exercise aids was significantly related to physical activity in adolescent girls but not boys. An interaction effect indicated that the relationship between home-use exercise equipment and physical activity levels was specific for girls in neighborhoods perceived as less-safe (OR = 4.40), rather than those perceived as safe (OR = 1.07, P < 0.01). In the parent sample, home-use (OR = 1.24) and outdoor use (OR = 1.16) exercise aids were significantly related to physical activity levels. An interaction between outdoor exercise aids and safety indicated that the effect was specific to parents who lived in neighborhoods perceived as safe (OR = 2.43) compared to those perceived as less-safe (OR = 0.91, P < 0.01). CONCLUSION Girls living in neighborhoods their parents perceive to be less-safe may benefit from having exercise equipment they can use in the home. Parents living in neighborhoods perceived to be safe may benefit from having exercise aids that they can use outside.
A compact tandem two-step laser time-of-flight mass spectrometer for in situ analysis of non-volatile organics on planetary surfaces

Two-step laser desorption mass spectrometry is a well suited technique to the analysis of high priority classes of organics, such as polycyclic aromatic hydrocarbons, present in complex samples. The use of decoupled desorption and ionization laser pulses allows for sensitive and selective detection of structurally intact organic species. We have recently demonstrated the implementation of this advancement in laser mass spectrometry in a compact, flight-compatible instrument that could feasibly be the centerpiece of an analytical science payload as part of a future spaceflight mission to a small body or icy moon.
THE POLITICAL ECONOMY OF STAYING OUTSIDE THE EUROZONE: POLAND AND SWEDEN COMPARED

This paper deals with the issue of political constraints put on economic policies that derive from the distribution of power in democratic societies. Poland and Sweden are both euro-outsiders that are obliged to adopt the euro, but recent developments within the Eurozone and related to the 2008+ crisis engendered widespread reluctance among the public to give up national currencies. Within a short time, the general support for the euro turned strongly negative, making it a grave challenge for politicians to pursue the adoption of the common currency. On this background, we reflect on the alleged correspondence between these two countries that would allow to follow similar policies toward euro introduction. We point to the idiosyncrasy of the Swedish case that makes it virtually impossible to emulate its policies by a country like Poland with very different long-term goals and starting conditions. By doing so, we highlight the context of policymaking that seems crucial to a successful art of political economy.
Parameterization of oceanic whitecap fraction based on satellite observations

Satellite-based whitecap fraction (W) data have been used to predict sea spray aerosol (SSA) emission rates. This allows to evaluate how an account for natural variability of whitecaps in the W parameterization would affect SSA mass flux predictions when using a sea spray source function (SSSF) based on the whitecap method. Data set containing W data for 2006 together with matching wind speed U10 and sea surface temperature (SST) T has been used. Whitecap fraction W was estimated from observations of the ocean surface brightness temperature TB by satellite-borne radiometers at two frequencies (10 and 37 GHz). A global scale assessment of the data set yielded approximately quadratic correlation between W and U10. A regional scale analysis yielded a new W(U10, T) parameterization which explicitly accounted for the effect of SST on W. The analysis of W values obtained with the new W(U10) and W(U10, T) parameterizations indicates that the influence of secondary factors on W is for the largest part embedded in the exponent of the wind speed dependence. In addition, the W(U10, T) parameterization is capable to model the spread (or variability) of the satellite-based W data. The satellite-based parameterization W(U10, T) was applied in an SSSF to estimate the global SSA emission rate. The thus obtained SSA production rate is within previously reported estimates, however with distinctly different spatial distribution.
Revision, uptake and coding issues related to the open access Orchard Sports Injury Classification System (OSICS) versions 8, 9 and 10.1

The Orchard Sports Injury Classification System (OSICS) is one of the world’s most commonly used systems for coding injury diagnoses in sports injury surveillance systems. Its major strengths are that it has wide usage, has codes specific to sports medicine and that it is free to use. Literature searches and stakeholder consultations were made to assess the uptake of OSICS and to develop new versions. OSICS was commonly used in the sports of football (soccer), Australian football, rugby union, cricket and tennis. It is referenced in international papers in three sports and used in four commercially available computerised injury management systems. Suggested injury categories for the major sports are presented. New versions OSICS 9 (three digit codes) and OSICS 10.1 (four digit codes) are presented. OSICS is a potentially helpful component of a comprehensive sports injury surveillance system, but many other components are required. Choices made in developing these components should ideally be agreed upon by groups of researchers in consensus statements.
Data Analytics for Managing Power in Commercial Buildings

Commercial buildings are significant consumers of electricity. We propose a number of methods for managing power in commercial buildings. The first step toward better energy management in commercial buildings is monitoring consumption. However, instrumenting every electrical panel in a large commercial building is an expensive proposition. In this article, we demonstrate that it is also unnecessary. Specifically, we propose a greedy meter (sensor) placement algorithm based on maximization of information gain subject to a cost constraint. The algorithm provides a near-optimal solution guarantee, and our empirical results demonstrate a 15% improvement in prediction power over conventional methods. Next, to identify power-saving opportunities, we use an unsupervised anomaly detection technique based on a low-dimensional embedding. Furthermore, to enable a building manager to effectively plan for demand response programs, we evaluate several solutions for fine-grained, short-term load forecasting. Our investigation reveals that support vector regression and an ensemble model work best overall. Finally, to better manage resources such as lighting and HVAC, we propose a semisupervised approach combining hidden Markov models (HMMs) and a standard classifier to model occupancy based on readily available port-level network statistics. We show that the proposed two-step approach simplifies the occupancy model while achieving good accuracy. The experimental results demonstrate an average occupancy estimation error of 9.3% with a potential reduction of 9.5% in lighting load using our occupancy models.
A 37.6mm2 1024-channel high-compliance-voltage SoC for epiretinal prostheses

Retinal implants elicit light perception for people blinded by photoreceptor loss. Commercialized 60-channel retinal prostheses allow patients to perform simple tasks, but several hundreds to a thousand electrodes are required for face recognition/reading [1,2], posing great challenges for the design of next-generation retinal stimulators. Aside from the higher power/data demand, the electrode impedance is also increased. Placing 1000 epiretinal electrodes in the 5mm-diameter macula region reduces the electrode size to less than 0.01mm2, leading to a 30kΩ electrode-tissue impedance [2]. To elicit light perception of various brightness levels, the stimulators for epiretinal prostheses require an output compliance voltage of ±10V [3], thus requiring area-consuming high-voltage (HV) transistors. The stimulator in [4] achieves 1600 channels, but it is designed for subretinal rather than epiretinal prostheses. It has ±2V compliance and needs a separate chip for power telemetry. For epiretinal prostheses, an HV-compliant 1024-channel stimulator in [3] is estimated to occupy 64mm2 and requires off-chip diodes for power rectification. For a space-restricted retinal implant, a small-sized fully integrated SoC with minimal number of off-chip components is preferred.