Miracle-dz/UniFAR-FTUs huggingface dataset:
Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins.

GPI lipid anchoring is an important post-translational modification of eukaryote proteins in the endoplasmic reticulum. In total, 19 genes have been directly implicated in the anchor synthesis and the substrate protein modification pathway. Here, the molecular functions of the respective proteins and their evolution are analyzed in the context of reported literature data and sequence analysis studies for the complete pathway (http://mendel.imp.univie.ac.at/SEQUENCES/gpi-biosynthesis/) and questions for future experimental investigation are discussed. Studies of two of these proteins have provided new mechanistic insights. The cytosolic part of PIG-A/GPI3 has a two-domain alpha/beta/alpha-layered structure; it is suggested that its C-terminal subsegment binds UDP-GlcNAc whereas the N-terminal domain interacts with the phosphatidylinositol moiety. The lumenal part of PIG-T/GPI16 apparently consists of a beta-propeller with a central hole that regulates the access of substrate protein C termini to the active site of the cysteine protease PIG-K/GPI8 (gating mechanism) as well as of a polypeptide hook that embraces PIG-K/GPI8. This structural proposal would explain the paradoxical properties of the GPI lipid anchor signal motif and of PIG-K/GPI8 orthologs without membrane insertion regions in some species.
Application of needle-knife in difficult biliary cannulation for endoscopic retrograde cholangiopancreatography.

BACKGROUND Getting directly into the common bile duct (CBD) is the most important step for successful therapeutic biliary endoscopy. In 5%-10% of cases, the CBD remains inaccessible, necessitating pre-cut papillotomy or fistulotomy with a needle-knife. The aim of this study was to assess the value of early application of the needle-knife in difficult biliary cannulation for endoscopic retrograde cholangiopancreatography (ERCP). METHODS Patients with failed biliary cannulation after 10 minutes or guide wire entering the pancreatic tube 3 times were randomly divided into group of needle-knife cut and group of persistent cannulation by standard techniques. The cannulation times, success rates and complication rates were compared between the two groups. RESULTS A total of 948 therapeutic biliary ERCP procedures were performed between October 2004 and February 2006. Of 91 patients with difficult biliary cannulation, 43 patients underwent needle-knife cut: the cannulation success rate was 90.7%, the mean cannulation time was 5.6 minutes, and the complication rate was 9.3%. The other 48 patients underwent persistent cannulation by standard techniques: the cannulation success rate was 75%, the mean cannulation time was 10.2 minutes, and the complication rate was 14.6%. Significant differences were observed in cannulation success rate and cannulation time but in complication rate between the two groups. CONCLUSION The early application of the needle-knife in difficult biliary cannulation is time-saving, safe and effective, with no increase in complication rate.
Emerging Economies, Productivity Growth and Trade with Resource‐Rich Economies by 2030

Rapid economic growth in some emerging economies in recent decades has significantly increased their global economic importance. If this rapid growth continues and is strongest in resource-poor Asian economies, the growth in global demand for imports of primary products also will continue, to the on-going benefit of natural resource-rich countries. This paper explores how global production, consumption and trade patterns might change over the next two decades in the course of economic development and structural changes under various scenarios. We employ the GTAP model and Version 8.1 of the GTAP database with a base year of 2007, along with supplementary data from a range of sources, to support projections of the global economy to 2030. We first project a baseline assuming trade-related policies do not change in each region but that factor endowments and real GDP grow at exogenously estimated rates. That baseline is compared with two alternative scenarios: one in which the growth rates of China and India are lower by one-quarter, and the other in which this slowdown in emerging economies leads to slower productivity growth in the primary sectors of all countries. Throughout the results, implications are drawn out for natural resource-abundant economies, including Australia and New Zealand.
Impact of Different Standardized Uptake Value Measures on PET-Based Quantification of Treatment Response

PET-based treatment response studies typically measure the change in the standardized uptake value (SUV) to quantify response. The relative changes of different SUV measures, such as maximum, peak, mean, or total SUVs (SUVmax, SUVpeak, SUVmean, or SUVtotal, respectively), are used across the literature to classify patients into response categories, with quantitative thresholds separating the different categories. We investigated the impact of different SUV measures on the quantification and classification of PET-based treatment response. Methods: Sixteen patients with solid malignancies were treated with a multitargeted receptor tyrosine kinase inhibitor, resulting in a variety of responses. Using the cellular proliferation marker 3′-deoxy-3′-18F-fluorothymidine (18F-FLT), we acquired whole-body PET/CT scans at baseline, during treatment, and after treatment. The highest 18F-FLT uptake lesions (∼2/patient) were segmented on PET images. Tumor PET response was assessed via the relative change in SUVmax, SUVpeak, SUVmean, and SUVtotal, thereby yielding 4 different responses for each tumor at mid- and posttreatment. For each SUV measure, a population average PET response was determined over all tumors. Standard deviation (SD) and range were used to quantify variation of PET response within individual tumors and population averages. Results: Different SUV measures resulted in substantial variation of individual tumor PET response assessments (average SD, 20%; average range, 40%). The most extreme variation between 4 PET response measures was 90% in individual tumors. Classification of tumor PET response depended strongly on the SUV measure, because different SUV measures resulted in conflicting categorizations of PET response (ambiguous treatment response assessment) in more than 80% of tumors. Variation of the population average PET response was considerably smaller (average SD, 7%; average range, 16%), and this variation was not statistically significant. Differences in tumor PET response were greatest between SUVmean and SUVtotal and smallest between SUVmax and SUVpeak. Variations of tumor PET response at midtreatment and posttreatment were similar. Conclusion: Quantification and classification of PET-based treatment response in individual patients were strongly affected by the SUV measure used to assess response. This substantial uncertainty in individual patient PET response was present despite the concurrent robustness of the population average PET response. Given the ambiguity of individual patient PET responses, selection of PET-based treatment response measures and their associated thresholds should be carefully optimized.
The Asymptotic Analysis of Some Packet Radio Networks

The purpose of this paper is to present an asymptotic performance analysis of a class of multihop radio networks using the calculus of residues. The analysis provides a closed-form approximation of global performance measures, whose precision increases exponentially with the size of the system. The complexity of computing these approximations is independent of the problem size. The method is easily applicable to a variety of topologies and access protocols.
Reporting Agency Performance: Behind the SEC's Enforcement Statistics

Every October, after the end of its fiscal year, the Securities and Exchange Commission releases its annual enforcement report, detailing its activity for the year. The report boasts record enforcement activity, often showing significant increases over the prior fiscal year in the number of enforcement actions brought and monetary penalties ordered. The numbers suggest that the SEC is ever tougher on securities violators. The SEC includes these statistics in its budget requests; the figures are repeated in congressional testimony, scholarship, policy proposals, and the business press.Yet the SEC’s metrics are deeply flawed. The Article, a pilot study, reviews fifteen years of enforcement actions and demonstrates that the widely-circulated statistics are invalid because they do not measure what they purport to measure, and unreliable because they are inconsistent and can be manipulated all too easily. The SEC double and triple counts many of the enforcement actions it brings and overstates the fines it orders. Once these measures are adjusted, they reveal that enforcement remained steady between 2002 and 2014, and obscure a shift in enforcement towards easier-to-prosecute strict-liability violations. The SEC is not alone in using statistics that have a propensity to mislead to report its output. Multiple reporting statutes authorize Congress to cut agencies’ budgets for failing to meet performance targets. In response, agencies report flawed statistics to protect their ability to continue enforcing the law. The Article suggests that Congress should not threaten to reduce an agency’s budget because of year-to-year fluctuations in enforcement. In addition, to make reported numbers more reliable, non-financial performance measures should not be developed by the agency. Instead, the selection and development of performance indicators should be outsourced and possibly standardized across agencies, much like financial reporting has already been standardized. Doing so would depoliticize reporting, as well as facilitate comparisons among agencies, both domestically and internationally.
The research and design Of 3D Web guide system based On WebGL

The development of virtual reality technology made it possible to run 3D program on the Web. This 3D guide system used three. Js class library based on WebGL to import 3D model into this system to build 3D scenes, then controlled the scene through the Javascript, and calculated the optimal path between scenes and scenes in the system by combining A* algorithm with the breadth-first search algorithm to enrich the function of the application system. This system can be applied to guide in the large amusement parks and large shopping malls. It is a new kind of advertising for enterprises and also a new attempt of 3D Web application.
Systematics of the Neotropical genus Catharylla Zeller (Lepidoptera, Pyralidae s. l., Crambinae)

Abstract The Neotropical genus Catharylla Zeller, 1863 (type species: Crambus tenellus Zeller, 1839) is redescribed. Catharylla contiguella Zeller, 1872, C. interrupta Zeller, 1866 and Myelois sericina Zeller, 1881, included by Munroe (1995) in Catharylla, are moved to Argyria Hübner. Catharylla paulella Schaus, 1922 and C. tenellus (Zeller, 1839) are redescribed. Six new species are described by Léger and Landry: C. bijuga, C. chelicerata, C. coronata, C. gigantea, C. mayrabonillae and C. serrabonita. The phylogenetic relationships were investigated using morphological as well as molecular data (COI, wingless, EF-1α genes). The median and subterminal transverse lines of the forewing as well as the short anterior and posterior apophyses of the female genitalia are characteristic of the genus. The monophyly of Catharylla was recovered in all phylogenetic analyses of the molecular and the combined datasets, with three morphological apomorphies highlighted. Phylogenetic analyses of the morphology of the two sexes recovered three separate species groups within Catharylla: the chelicerata, the mayrabonillae, and the tenellus species groups. The possible position of Micrelephas Schaus, 1922 as sister to Catharylla, based on both morphological and molecular data, and the status of tribe Argyriini are discussed. The biogeographical data indicate that the chelicerata species group is restricted to the Guyanas and the Amazonian regions whereas the tenellus group is restricted to the Atlantic Forest in the South-Eastern part of Brazil. The mayrabonillae group is widespread from Costa Rica to South Bolivia with an allopatric distribution of the two species. COI barcode sequences indicate relatively strong divergence within C. bijuga, C. mayrabonillae, C. serrabonita and C. tenellus.
The safety and serious adverse events of approved ALK inhibitors in malignancies: a meta-analysis

Background: A total of 2%–7% of non-small cell lung cancer (NSCLC) patients have anaplastic lymphoma kinase (ALK) mutations. At present, three or more generations of ALK inhibitors have been used for ALK-positive NSCLC treatment, including crizotinib, alectinib, ceritinib, and brigatinib. Although most adverse events (AEs) of ALK inhibitors are grades 1 to 2 and generally can be well tolerated, serious adverse events (SAEs) of ALK inhibitors lack data analysis, and the lung toxicity of ALK inhibitors needs attention. Thus, we performed this meta-analysis to evaluate the safety of ALK inhibitors, especially in terms of drug-related SAEs. Methods: A total of 19 studies from 4 databases (PubMed, Science Direct, ClinicalTrials.gov and Cochrane Library) were included in this meta-analysis. All statistical analyses in this meta-analysis were performed with the STATA 14.0 software. We analyzed the incidences of total AEs, total SAEs and SAEs for different ALK inhibitors. Results: AEs of the ALK inhibitors occurred in almost all participants, and SAEs occurred in more than 20% of the participants. For ceritinib and brigatinib, SAEs occurred in more than 40% of the participants. Alectinib is most likely the safest of the two generations of ALK inhibitors. Generally, the ALK inhibitors showed significant lung toxicity. Conclusion: In conclusion, attention should be focused on ALK inhibitor-related SAEs, especially lung toxicity. According to this meta-analysis, alxectinib seems to be the safest ALK inhibitor. Physicians should focus on the related SAEs when prescribing ALK inhibitors.
Co-RAM: combinational logic synthesis applied to software partitions for mapping to a novel memory device

We introduce the application of current techniques for hardware synthesis of combinational logic blocks to large-scale software partitions for eventual implementation of these partitions in a novel memory device called "Co-RAM. " The novelty of our approach is based upon the observation that a wide variety of largescale software functionality can be considered "stateless" by conventional hardware synthesis tools and so may be realized as combinational logic. By limiting the functions placed in memory to combinational functions, we eliminate conventional synchronization overhead associated with coprocessors. A significant aspect of Co-RAM is that it is a system design concept that inherently merges hardware and software design styles at the system level, impacting programming styles, system build approaches, and the programmer's view of the underlying machine. A direct consequence of viewing the functionality as combinational is that the system state is not partitioned with the tasks. By Considering Co-RAM functionality to be stateless with respect to system state, Co-RAM functionality is inlined around the advancement of effectively unpartitioned system state. The rules for procedural combinational logic synthesis are shown to apply to a wide variety of software partitions. Results of our investigation project speedups of 8/spl times/ to 1000/spl times/ for a range of algorithms of varying problem size and for projected devices ranging from conventional field programmable gate arrays (FPGAs) to highly specific combinational logic devices.
A Solar Decathlon Materials Selection Study

A team of students from the Lucerne University of Applied Sciences and Arts (HSLU) is competing at the 2014 Solar Decathlon competition in Versailles, France. Using WPI’s 2013 Solatrium House as a benchmark, the purpose of this project was to observe, evaluate and document the HSLU team’s material selection process for their your+ house. We provided recommendations to improve the entirety of the dynamic decision-making processes. In addition, we created a manual for the Life Cycle Assessment software, SimaPro®, which can be used to assist inexperienced users. The recommendations we made will help improve team strategies for future competitions.
Streptidinium sulfate monohydrate.

In streptidinium sulfate monohydrate {systematic name: 1,1'-[(1S,3R,4S,6R)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl]diguanidinium sulfate monohydrate}, C(8)H(20)N(6)O(4)(2+). SO(4)(2-). H(2)O, at 100 (2) K, the components are arranged in double helices based on hydrogen bonds. One helix contains streptidinium cations and the other contains disordered sulfate anions and solvent water molecules. The helices are linked into a three-dimensional hydrogen-bonded network by O-H.O and N-H.O hydrogen bonds.
Effects of repeated petting sessions on leukocyte counts, intestinal parasite prevalence, and plasma cortisol concentration of dogs housed in a county animal shelter.

OBJECTIVE To describe changes in WBC counts, plasma cortisol concentration, and fecal parasite shedding of dogs housed in an animal shelter and determine the effects of daily petting sessions on these variables. DESIGN Hybrid prospective observational and experimental study. ANIMALS 92 healthy dogs newly arrived to an animal shelter and 15 healthy privately owned dogs (control group). PROCEDURES Blood and fecal samples were collected from shelter dogs 1, 3, and 10 days after arrival and from control dogs once. A subset of shelter dogs (n = 15) was assigned to receive 30 minutes of petting daily. Plasma cortisol concentration was measured, CBCs were performed, and fecal samples were evaluated for parasite ova. RESULTS For shelter dogs, total leukocyte, neutrophil, and lymphocyte counts increased significantly between days 1 and 10, with less consistent increases in monocyte count and neutrophil-to-lymphocyte count ratio. Parasite shedding was unaffected by duration of shelter stay but was greater for shelter versus control dogs. For shelter dogs, plasma cortisol concentration decreased with time and was higher than that of control dogs on each day. Total leukocyte, neutrophil, and monocyte counts and neutrophil-to-lymphocyte count ratios were also higher for shelter versus control dogs. Petting sessions resulted in a decrease in plasma cortisol concentration but in no other variables. CONCLUSIONS AND CLINICAL RELEVANCE Large increasing immunologic responses, heavy parasite shedding, and high but decreasing plasma cortisol concentration were identified in shelter dogs. Daily 30-minute petting sessions affected only cortisol values, so the clinical importance of petting for immunologic and other health outcomes remains unclear.
Liquidity and Equity Short Term Fragility: Stress Tests for the European Banking System

This paper investigates the impact of extreme shocks on stock and bond markets on listed European banks. The originality of our approach consists in dealing jointly with stock and bond markets and taking into account their interdependencies in case of extreme events by using a specific CVRF (CVine Risk Factor) model which combines copulas and a factorial structure. Moreover, contrary to what is generally done in the literature, we do not focus only on the responses of the stock returns but we also examine the response of the balance sheets of the banks and particularly of their short term assets in order to assess their fragility in terms of liquidity. Our main findings are the following: 1) the nature of the banks' fragility has changed: today, the interest rate risk should be the first concern before the equity risk, as the banks have extensively increased their exposition to bond market due to flight-to-quality reactions and to large investments in governments bonds after the rescue operations the banks have benefited; 2) in case of a surge in the interest rate and in the links between stock and bond returns, the portfolios of the biggest banks in Europe would experience very severe shortfalls for both equity and liquidity buffers. Accordingly regulators should monitor the evolution of dependencies between assets and should pay utmost attention to the positive links between stock and bond returns.
Multi-label classification with meta-label-specific features

Multi-label classification has attracted many attentions in various fields, such as text categorization and semantic image annotation. Aiming to classify an instance into multiple labels, various multi-label classification methods have been proposed. However, the existing methods typically build models in the identical feature (sub)space for all labels, possibly inconsistent with real-world problems. In this paper, we develop a novel method based on the assumption that meta-labels with specific features exist in the scenario of multi-label classification. The proposed method consists of meta-label learning and specific feature selection. Experiments on twelve benchmark multi-label datasets show the efficiency of the proposed method compared with several state-of-the-art methods.
Therapy with efavirenz plus indinavir in patients with extensive prior nucleoside reverse-transcriptase inhibitor experience: a randomized, double-blind, placebo-controlled trial.

A randomized, double-blind, placebo-controlled trial compared efavirenz (600 mg every 24 h) plus indinavir (1000 mg every 8 h) with placebo (every 24 h) plus indinavir (800 mg every 8 h) among 327 nucleoside analogue reverse-transcriptase inhibitor (NRTI)-experienced human immunodeficiency virus (HIV)-infected adults. Patients received </=2 concomitant NRTIs. Eligible patients had CD4 cell counts >50 cells/mm(3), >10,000 plasma HIV-1 RNA copies/mL, and no prior protease inhibitor or non-NRTI therapy. Patients had a mean of 2.8 years of prior NRTI therapy. At 24 weeks, plasma HIV-1 RNA level was <400 copies/mL in 68.2% of efavirenz versus 52.4% of placebo recipients (P=.004). CD4 cell count increases were 104+/-9 cells/mm(3) and 77+/-10 cells/mm(3) in efavirenz and placebo recipients, respectively (P=.023). Responses in efavirenz recipients were sustained at 48 weeks. Thus, efavirenz plus indinavir with concomitant NRTIs is effective therapy for NRTI-experienced patients.
Speeding Up Homomorpic Hashing Using GPUs

Homomorphic hash functions (HHFs) have been applied into peer-to-peer networks with erasure coding or network coding to defend against pollution attacks. Unfortunately HHFs are computationally expensive for contemporary CPUs, This paper to exploit the computing power of graphic processing units (GPUs) for homomorphic hashing. Specifically, we demonstrate how to use NVIDIA GPUs and the computer unified device architecture (CUDA) programming model to achieve 38 times of speedup over the CPU counterpart. We also develop a multi-precision modular arithmetic library on CUDA platform, which is not only key to our specific application, but also very useful for a large number of cryptographic applications.