Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Expertise Assessment on the Quality of Task Routing in Human Computation

Human computation systems are characterized by the use of human workers to solve computationally difficult problems. Expertise profiling involves assessment and representation of a worker’s expertise, in order to route human computation tasks to appropriate workers. This paper studies the relationship between the assessment workload on workers and the quality of task routing. Three expertise assessment approaches were compared with the help of a user study, using two different groups of human workers. The first approach requests workers to provide selfassessment of their knowledge. The second approach measures the knowledge of workers through their performance against tasks with known responses. We propose a third approach based on a combination of selfassessment and task-assessment. The results suggest that the self-assessment approach requires minimum assessment workload from workers during expertise profiling. By comparison, the task-assessment approach achieved the highest response rate and accuracy. The proposed approach requires less assessment workload, while achieving the response rate and accuracy similar to the task-assessment approach. Author Keywords Human computation, expertise assessment, task routing
Cataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pig-Tailed Macaques by Using a Systems Biology Approach

ABSTRACT Our earlier studies with pig-tailed macaques demonstrated various simian-human immunodeficiency virus (SHIV) susceptibilities during the menstrual cycle, likely caused by cyclic variations in immune responses in the female genital tract. There is concern that high-dose, long-lasting, injectable progestin-based contraception could mimic the high-progesterone luteal phase and predispose women to human immunodeficiency type 1 (HIV-1) acquisition and transmission. In this study, we adopted a systems biology approach employing proteomics (tandem mass spectrometry), transcriptomics (RNA microarray hybridization), and other specific protein assays (enzyme-linked immunosorbent assays and multiplex chemokine and cytokine measurements) to characterize the effects of hormonal changes on the expression of innate factors and secreted proteins in the macaque vagina. Several antiviral factors and pathways (including acute-phase response signaling and complement system) were overexpressed in the follicular phase. Conversely, during the luteal phase there were factors overexpressed (including moesins, syndecans, and integrins, among others) that could play direct or indirect roles in enhancing HIV-1 infection. Thus, our study showed that specific pathways and proteins or genes might work in tandem to regulate innate immunity, thus fostering further investigation and future design of approaches to help counter HIV-1 acquisition in the female genital tract. IMPORTANCE HIV infection in women is poorly understood. High levels of the hormone progesterone may make women more vulnerable to infection. This could be the case during the menstrual cycle, when using hormone-based birth control, or during pregnancy. The biological basis for increased HIV vulnerability is not known. We used an animal model with high risk for infection during periods of high progesterone. Genital secretions and tissues during the menstrual cycle were studied. Our goal was to identify biological factors upregulated at high progesterone levels, and we indeed show an upregulation of genes and proteins which enhance the ability of HIV to infect when progesterone is high. In contrast, during low-progesterone periods, we found more HIV inhibitory factors. This study contributes to our understanding of mechanisms that may regulate HIV infection in females under hormonal influences. Such knowledge is needed for the development of novel prevention strategies.
The Circulating Concentration and 24-h Urine Excretion of Magnesium Dose- and Time-Dependently Respond to Oral Magnesium Supplementation in a Meta-Analysis of Randomized Controlled Trials.

BACKGROUND Accurate determination of Mg status is important for improving nutritional assessment and clinical risk stratification. OBJECTIVE We aimed to quantify the overall responsiveness of Mg biomarkers to oral Mg supplementation among adults without severe diseases and their dose- and time responses using available data from randomized controlled trials (RCTs). METHODS We identified 48 Mg supplementation trials (n = 2131) through searches of MEDLINE and the Cochrane Library up to November 2014. Random-effects meta-analysis was used to estimate weighted mean differences of biomarker concentrations between intervention and placebo groups. Restricted cubic splines were used to determine the dose- and time responses of Mg biomarkers to supplementation. RESULTS Among the 35 biomarkers assessed, serum, plasma, and urine Mg were most commonly measured. Elemental Mg supplementation doses ranged from 197 to 994 mg/d. Trials ranged from 3 wk to 5 y (median: 12 wk). Mg supplementation significantly elevated circulating Mg by 0.04 mmol/L (95% CI: 0.02, 0.06) and 24-h urine Mg excretion by 1.52 mmol/24 h (95% CI: 1.20, 1.83) as compared to placebo. Circulating Mg concentrations and 24-h urine Mg excretion responded to Mg supplementation in a dose- and time-dependent manner, gradually reaching a steady state at doses of 300 mg/d and 400 mg/d, or after ~20 wk and 40 wk, respectively (all P-nonlinearity ≤ 0.001). The higher the circulating Mg concentration at baseline, the lower the responsiveness of circulating Mg to supplementation, and the higher the urinary excretion (all P-linearity < 0.05). In addition, RBC Mg, fecal Mg, and urine calcium were significantly more elevated by Mg supplementation than by placebo (all P-values < 0.05), but there is insufficient evidence to determine their responses to increasing Mg doses. CONCLUSIONS This meta-analysis of RCTs demonstrated significant dose- and time responses of circulating Mg concentration and 24-h urine Mg excretion to oral Mg supplementation.
X-ray and DFT-calculated structures of bis[N-(quinolin-8-yl)benzamidato-κ(2)N,N']copper(II).

The application of transition metal chelates as chemotherapeutic agents has the advantage that they can be used as a scaffold around which ligands with DNA recognition elements can be anchored. The facile substitution of these components allows for the DNA recognition and binding properties of the metal chelates to be tuned. Copper is a particularly interesting choice for the development of novel metallodrugs as it is an endogenous metal and is therefore less toxic than other transition metals. The title compound, [Cu(C16H11N2O)2], was synthesized by reacting N-(quinolin-8-yl)benzamide and the metal in a 2:1 ratio. Ligand coordination required deprotonation of the amide N-H group and the isolated complex is therefore neutral. The metal ion adopts a flattened tetrahedral coordination geometry with the ligands in a pseudo-trans configuration. The free rotation afforded by the formal single bond between the amide group and phenyl ring allows the phenyl rings to rotate out-of-plane, thus alleviating nonbonded repulsion between the phenyl rings and the quinolyl groups within the complex. Weak C-H.O interactions stabilize a dimer in the solid state. Density functional theory (DFT) simulations at the PBE/6-311G(dp) level of theory show that the solid-state structure (C1 symmetry) is 79.33 kJ mol(-1) higher in energy than the lowest energy gas-phase structure (C2 symmetry). Natural bond orbital (NBO) analysis offers an explanation for the formation of the C-H.O interactions in electrostatic terms, but the stabilizing effect is insufficient to support the dimer in the gas phase.
Driver Hypo-vigilance Detection Based on Eyelid Behavior

Driver face monitoring system is a real-time system that can detect driver fatigue and driver distraction using machine vision approaches. In this paper, a new algorithm is proposed for driver hypo-vigilance detection based on eye-region processing and without explicit eye detection stage. In this method, horizontal projection of top half-segment of facial image is used to extract symptoms of fatigue and distraction. Percentage of eye closure (PERCLOS) and eyelid distance changes during time are used for fatigue detection; and eye closure rate is used for distraction detection. The novelty of our method is in adaptive feature extraction using spatio-temporal processing without explicit eye detection. Processing rate of proposed method is more than 5 frames per second.
Information Design: A Unified Perspective

Given a game with uncertain payoffs, information design analyzes the extent to which the provision of information alone can influence the behavior of the players. Information design has a literal interpretation, under which there is a real information designer who can commit to the choice of the best information structure (from her perspective) for a set of participants in a game. We emphasize a metaphorical interpretation, under which the information design problem is used by the analyst to characterize play in the game under many different information structures. We provide an introduction to the basic issues and insights of a rapidly growing literature in information design. We show how the literal and metaphorical interpretations of information design unify a large body of existing work, including that on communication in games (Myerson 1991), Bayesian persuasion (Kamenica and Gentzkow 2011), and some of our own recent work on robust predictions in games of incomplete information. ( JEL C70, D82, D83)
Dialogue Structure and Pronoun Resolution

Abstract : This paper presents an empirical evaluation of a pronoun resolution algorithm augmented with discourse segmentation information. Past work has shown that segmenting discourse can aid in pronoun resolution by making potentially erroneous candidates inaccessible to a pronoun's search. However, implementing this in practice has been difficult given the complexities associated with deciding on a useful scheme and then generating the segmentation reliably. In our study, we investigate whether or not shallow schemes that are easy to generate will improve pronoun resolution in a task-oriented corpus of dialogues. Our results show that incorporating this shallow segmentation at best marginally improves pronoun resolution performance.
Recombinant Phospholipase Cζ Has High Ca2+ Sensitivity and Induces Ca2+ Oscillations in Mouse Eggs*

Sperm-specific phospholipase Cζ (PLCζ) is known to induce intracellular Ca2+ oscillations and subsequent early embryonic development when expressed in mouse eggs by injection of RNA encoding PLCζ (Saunders, C. M., Larman, M. G., Parrington, J., Cox, L. J., Royse, J., Blayney, L. M., Swann, K., and Lai, F. A. (2002) Development 129, 3533-3544). The present study addressed characteristics of purified mouse PLCζ protein that was synthesized using the baculovirus/Sf9 cell expression system. Microinjection of recombinant PLCζ protein into mouse eggs induced serial Ca2+ spikes quite similar to those produced by the injection of sperm extract, probably because of repetitive Ca2+ release from the endoplasmic reticulum caused by continuously produced inositol 1,4,5-trisphosphate. Recombinant PLCδ1 also induced Ca2+ oscillations, but a 20-fold higher concentration was required compared with PLCζ. In the enzymatic assay of phosphatidylinositol 4,5-bisphosphate hydrolyzing activity in vitro at various calcium ion concentrations ([Ca2+]), PLCζ exhibited a significant activity at [Ca2+] as low as 10 nm and had 70% maximal activity at 100 nm [Ca2+] that is usually the basal intracellular calcium ion concentration level of cells. On the other hand, the activity of PLCδ1 increased at a [Ca2+] between 1 and 30 μm. EC50 was 52 nm for PLCζ and 5.7 μm for PLCδ1. Thus, PLCζ has an ∼100-fold higher Ca2+ sensitivity than PLCδ1. The ability of purified PLCζ protein to induce Ca2+ oscillations qualifies PLCζ as a proper candidate of the mammalian egg-activating sperm factor. Furthermore, such a high Ca2+ sensitivity of PLC activity as PLCζ that can be active in cells at the resting state is thought to be an appropriate characteristic of the sperm factor, which is introduced into the ooplasm upon sperm-egg fusion, triggers Ca2+ release first, and maintains Ca2+ oscillations.
Development of IgG Mediated Antibody Dependent Cell-mediated Cytotoxicity (ADCC) in the Serum and Genital Mucosa of HIV Seroconverters

Background We measured antibody-dependent cell mediated cytotoxicity (ADCC) activity in serum and genital fluids of heterosexually exposed women during HIV seroconversion. Methods Plasma and cervico-vaginal lavage (CVL) fluid from 11 seroconverters (SC) were analyzed biannually from one year pre- to 6 year post-seroconversion using a 51Cr-release assay to measure HIV-1 gp120 specific ADCC. Results No SC had significant HIV specific CVL ADCC activity before seroconversion or until 1.5 yr after seroconversion. One individual had a %Specific Release (SR) of 25.4 at 2 years, 26.7 at 3 years and 21.0 at 4 years after seroconversion in CVL. Another sample had 4.7% SR at 2 years, 5.3 at 3 years, 10.9 at 4 years, and 8.4 at 5 years after seroconversion in CVL. A third had no activity until 17% SR 5 years after seroconversion in CVL. A fourth showed activity of 36.5% SR at 6.5 years after seroconversion. Seven women had no ADCC activity in their CVL. Paired serum samples showed HIV specific ADCC activity prior to the appearance of CVL ADCC activity. Conclusions HIV specific ADCC activity in CVL rose 2 years after seroconversion; ADCC was present in the serum prior to this time. These data suggest that genital tract ADCC activity is not present until well after acute infection.
TO A CONCEPTUAL FRAMEWORK FOR AUTOMATION KNOWLEDGE ACQUISITION IN SUPPLY CHAIN MANAGEMENT

In supply chain management, both academic and corporate interest concerning knowledge acquisition has shown an increasing trend in the past few years. This is evidenced by the significant amount of research written and published in journal special issues. In response to this trend, the present study has two objectives – first, it offers to provide an overview of literature concerning knowledge types and knowledge acquisition in the context of supply chain management discussed in 47 papers from the years 2001 to 2013. Second, it develops a conceptual framework that summarizes this field of research into four parts. Initially, knowledge types and AI techniques are highlighted, which leads to two specific perspectives: (1) supply chain knowledge, and (2) automation of knowledge acquisition for supply chain management. Companies’ practitioners and academics may avail of the review as it provides an overview of the fundamental research streams in the area. It then explains certain features of knowledge acquisition in the context of supply chains and the existing research limitations which could lead to future studies.
Numerical Simulation Research for CFST Columns under Blast Load

The impact of blast load is always taken into consideration in significant pillar bearing component and protective construction. The LS-DYNA software was employed to simulate three typical concrete filled steel tubular (CFST) columns under blast load. The JHC model was used for concrete material and the MAT_PLASTIC_KINEMATIC model which accounted for the strain rate used for steel. Three section concrete-filled steel tube columns are analyzed in different proportion of distance and get the damage form of pillars and displacement of key points. The results show: In proportion to the same distance, the antiknock ability of circular cross section is better than the other two sections. Although in filled concrete damage is serious, but the steel tube columns improve the ductility of the columns. With the increase of proportion of distance, pillar deformation gradually decrease.
Resolution in electron microscope autoradiography. III. Iodine-125, the effect of heavy metal staining, and a reassessment of critical parameters

Resolution for 125I-labeled specimens under electron microscope (EM) autoradiographic conditions was assessed experimentally. With this isotope the size of the silver halide crystal was the most important resolution-limiting factor. Heavy metal staining such as is routinely used in preparing animal tissues for EM autoradiography produced an improvement in resolution of approximately 15-20%. For a 500-1,000-A biological tissue section fixed with OsO4 and stained with uranyl acetate, we obtained resolution (half distance, HD) values of approximately 800 +/- 120 A using Ilford L4 emulsion and 500 +/- 70 A using a Kodak NTE-type emulsion. General aspects of resolution-limiting factors and comparison with 3H and 14C values are discussed.
Proofs that yield nothing but their validity or all languages in NP have zero-knowledge proof systems

In this paper the generality and wide applicability of Zero-knowledge proofs, a notion introduced by Goldwasser, Micali, and Rackoff is demonstrated. These are probabilistic and interactive proofs that, for the members of a language, efficiently demonstrate membership in the language without conveying any additional knowledge. All previously known zero-knowledge proofs were only for number-theoretic languages in NP fl CONP. Under the assumption that secure encryption functions exist or by using "physical means for hiding information, '' it is shown that all languages in NP have zero-knowledge proofs. Loosely speaking, it is possible to demonstrate that a CNF formula is satisfiable without revealing any other property of the formula, in particular, without yielding neither a satis@ing assignment nor properties such as whether there is a satisfying assignment in which xl = X3 etc. It is also demonstrated that zero-knowledge proofs exist "outside the domain of cryptography and number theory. " Using no assumptions. it is shown that both graph isomorphism and graph nonisomor- phism have zero-knowledge interactive proofs. The mere existence of an interactive proof for graph nonisomorphism is interesting, since graph nonisomorphism is not known to be in NP and hence no efficient proofs were known before for demonstrating that two graphs are not isomorphic.
FAMP, a Novel ApoA‐I Mimetic Peptide, Suppresses Aortic Plaque Formation Through Promotion of Biological HDL Function in ApoE‐Deficient Mice

Background Apolipoprotein (apo) A‐I is a major high‐density lipoprotein (HDL) protein that causes cholesterol efflux from peripheral cells through the ATP‐binding cassette transporter A1 (ABCA1), thus generating HDL and reversing the macrophage foam cell phenotype. Pre‐β1 HDL is the smallest subfraction of HDL, which is believed to represent newly formed HDL, and it is the most active acceptor of free cholesterol. Furthermore it has a possible protective function against cardiovascular disease (CVD). We developed a novel apoA‐I mimetic peptide without phospholipids (Fukuoka University ApoA‐I Mimetic Peptide, FAMP). Methods and Results FAMP type 5 (FAMP5) had a high capacity for cholesterol efflux from A172 cells and mouse and human macrophages in vitro, and the efflux was mainly dependent on ABCA1 transporter. Incubation of FAMP5 with human HDL or whole plasma generated small HDL particles, and charged apoA‐I‐rich particles migrated as pre‐β HDL on agarose gel electrophoresis. Sixteen weeks of treatment with FAMP5 significantly suppressed aortic plaque formation (scrambled FAMP, 31.3±8.9% versus high‐dose FAMP5, 16.2±5.0%; P<0.01) and plasma C‐reactive protein and monocyte chemoattractant protein‐1 in apoE‐deficient mice fed a high‐fat diet. In addition, it significantly enhanced HDL‐mediated cholesterol efflux capacity from the mice. Conclusions A newly developed apoA‐I mimetic peptide, FAMP, has an antiatherosclerotic effect through the enhancement of the biological function of HDL. FAMP may have significant atheroprotective potential and prove to be a new therapeutic tool for CVD.
Effect of povidone iodine on thyroid functions and urine iodine levels in caesarean operations

Abstract Objective: In the present study, the effects of povidone iodine (PI) used during Caesarean operations on maternal thyroid hormones and urine iodine levels in the infant and the mother were investigated. Design: Twenty-seven patients were allocated to the PI group I (Gr I), and 28 to the non-PI group (Group II). Maternal preoperative and 24th-h postoperative free T3 (fT3), freeT4 (fT4), TSH, and urine iodine levels were determined, as well as infant urine iodine values. Results: In both groups, fT3 levels before and after the operation were found to be reduced (p < 0.01, p = 0.01, respectively). However, the decrease in fT3 was approximately 1.5-fold higher in Gr I than in Gr II. TSH levels increased significantly in Gr I (p = 0.005). The urine iodine levels of the mothers increased 25% in Gr I, but only 2% in Gr II. Conclusions: The absorption of PI by the skin was found to lead to changes in fT3, TSH, and urine iodine excretion values in the mothers. The findings of this study of Caesarean operations, which have a short duration, might be a signal to be careful of thyroid hormone effects in operations lasting longer.
Perceptions of Health Care Provider Communication Activity Among American Cancer Survivors and Adults Without Cancer Histories: An Analysis of the 2003 Health Information Trends Survey (HINTS) Data

Provider communication is an important determinant of health outcomes. We examined the frequency with which five important communication activities were perceived by cancer survivors and adults without a history of cancer to have been performed by their primary care providers. We analyzed data on more than 5,000 adults drawn from the 2003 Health Information National Trends Survey (HINTS), a public dataset of the National Cancer Institute. We analyzed the responses to a question that asked how frequently the respondent's primary care provider had performed the following communication activities in the past 12 months: (1) listening carefully, (2) explaining things, (3) showing respect, (4) spending enough time, and (5) involving the patient in joint decision making. In addition, we compared responses among demographic subgroups. Results showed that regardless of health status or demographic characteristics, the 2003 HINTS respondents reported less than optimal rates of their providers “always” listening carefully, explaining things, showing respect, spending enough time, and involving them in joint decision making. Being Hispanic and having no usual provider or health insurance were associated with a significantly lower frequency of reporting that providers “always” performed the five communication activities (p < .05).
Rectangles algorithm for generating normal variates

We propose an algorithm for generating normal random variates that is based on the acceptance–rejection method and uses a piecewise majorizing function. The piecewise function has 2048 equal‐area pieces, 2046 of which are constant, and the two extreme pieces are curves that majorize the tails. The proposed algorithm has not only good performance from correlation induction perspective, but also works well from a speed perspective. It is faster than the inversion method by Odeh and Evans and most other methods. © 2011 Wiley Periodicals, Inc. Naval Research Logistics, 2011