Miracle-dz/UniFAR-FTUs huggingface dataset:
Adaptation and Preliminary Testing of the Developmental Coordination Disorder Questionnaire (DCDQ) for Children in India

ABSTRACT Aims: While Developmental Coordination Disorder (DCD) has gained worldwide attention, in India it is relatively unknown. The revised DCD Questionnaire (DCDQ′07) is one of the most utilized screening tools for DCD. The aim of this study was to translate the DCDQ′07 into the Hindi language (DCDQ-Hindi) and test its basic psychometric properties. Methods: The DCDQ′07 was translated following guidelines for cross cultural adaptation of instruments. Parents of 1100 children (5–15 years) completed the DCDQ-Hindi, of which 955 were considered for data analysis and 60 were retested randomly after 3 weeks for test–retest reliability. Results: The DCDQ-Hindi showed high internal consistency (α = .86) and moderate test–retest reliability (.73). Confirmatory factor analysis showed equivalence to the DCDQ′07. The% probable DCD using DCDQ′07 cutoff scores (≤57) ranged from 22% to 68%. Using more stringent cutoffs (≤36) it ranged from 5% to 9%. Significant difference was seen for gender (p < .05) in subset 1(gross-motor skills) total scores. Conclusions: The DCDQ-Hindi reveals promise for initial identification of Hindi speaking Indian children with DCD. Based on more stringent cut-off scores, the “probable prevalence” of children with risk of DCD in India appears to be around 6–7%. Research with larger sample and comparison with the MABC-2 or equivalent is needed.
Complete Genome Sequence of a γ-Hexachlorocyclohexane-Degrading Bacterium, Sphingobium sp. Strain MI1205

ABSTRACT Here, we report the complete genome sequence of a γ-hexachlorocyclohexane (γ-HCH)-degrading bacterium, Sphingobium sp. strain MI1205. The genome of MI1205 consists of two chromosomes and four plasmids with sizes of 33 to 292 kb. All the lin genes for γ-HCH metabolism are dispersed on the four plasmids.
SIC vs. JD: Uplink NOMA techniques for M2M random access

Uplink grant-free non-orthogonal multiple access (NOMA) is promising for machine-to-machine (M2M) communications to meet the requirement of sporadic short packets transmission of massive devices. In this paper, successive interference cancellation (SIC) and joint decoding (JD), as two well-known decoding techniques for NOMA, are analyzed for M2M random access. Due to the sporadic small packet transmission, a block-fading multiple access channel (BF-MAC) is considered, and the frequency-selectivity is also introduced. The achievable individual outage rate regions of SIC and JD, with deterministic active users, are first obtained based on individual outage events, then the analysis is extended to random access and the achievable individual outage rates and throughputs are derived. Numerical results show that SIC can perform as well as JD with relative low user load and transmission powers over frequency-flat BF-MAC. But with higher transmission powers or frequency-selectivity, the outage-limited maximum throughputs of JD are significantly higher than that of SIC.
Lymphocyte transformation induced by chemical modification of membrane components. II. Effect of neuraminidase treatment of responder cells on proliferation and cytotoxicity in indirect stimulation.

Neuraminidase treatment of responder cells in indirect periodate or indirect neuraminidase-galactose oxidase (NGO) stimulation of rat lymph node cells (LNC) led to proliferative responses that were substantially greater and faster than those of controls. The indirect responses followed bicellular kinetics, i.e., the number of cells that initially responded was a function of the product of the number of stimulator cells and the number of responder cells in the cultures. Indirect NGO stimulation between allogeneic stimulators and responders was very similar to that between syngeneic cells, and neuraminidase treatment of responders had similar effects in both cases. The indirect mitogenic response between allogeneic cells completely abrogated the expected mixed lymphocyte reaction (MLR). Neuraminidase treatment of stimulators had little effect on the kinetics or magnitude of the rat one-way MLR. Treatment of responders, however, led to a faster and stronger response as compared with the normal MLR response. Treatment of both stimulators and responders was essentially the same as treatment of responders alone. These results, and those for indirect stimulation, suggest that the ability of responder cells to receive a mitogenic signal from stimulator cells is modulated by the amount of sialic acid on the responder cell surface. Although more blast cells were produced in indirect NGO cultures with neuraminidase-treated responders, the cytotoxic activity of these cultures was not enhanced over that produced in normal indirect stimulation. In fact, when referred to the extent of cellular proliferation in each culture, the cytotoxic activity produced by indirect stimulation was higher than that produced either by direct NGO stimulation or by indirect stimulation with neuraminidase-treated responders. Thus indirect NGO stimulation selectively activates cytotoxic cells. The additional cells that are activated by direct NGO stimulation, or after neuraminidase treatment of indirect responders, do not appear to be cytotoxic.
Comparative Evaluation of Oxidative Stress Modulating and DNA Protective Activities of Aqueous and Methanolic Extracts of Acacia catechu

Background: Plant-derived bioactive compounds are becoming immensely important as potential drugs. Different solvents are being used for extraction of these phytochemicals. Evaluation of biological activities of aqueous plant extracts is important as water soluble compounds would be more beneficial with respect to certification, safety and commercial issues. Oxidative stress is involved in development of many diseases; therefore, antioxidants are now being looked upon as convincing therapeutics against such diseases. Natural antioxidants are in high demand because of their lesser side effects. This study aims to compare the antioxidant activity of aqueous and methanolic extracts of Acacia catechu—a traditional medicinal plant. Methods: The activity was examined using different in vitro systems including radical scavenging activity, lipid peroxidation and inhibition of •OH radical induced DNA damage using standard protocols. Results: Both aqueous and methanolic extracts of Acacia catechu show significant activities with no differences in the efficacies of water and methanol soluble bioactive compounds. Conclusions: Present study revealed that aqueous extract of A. catechu has equal potential to be used as antioxidants as compared to methanolic extract. This can contribute to increased demand of physiologically compatible bioactive compounds of natural origin.
Deterministic Replay for Multi-Core VxWorks Applications

Debugging is an important and yet expensive activity in software development. With the adoption of multi-core computing platform, the debugging of multi-core bugs on real-time platform becomes challenging. Those multi-core concurrency bugs are often called Heisenbugs, because they manifest randomly during replay. As a result, it would be difficult for a programmer to use cyclic debugging to locate the fault. In this work, we present a deterministic replay tool for multi-core real-time VxWorks applications. We combine static analysis and source code instrumentation to help record interleaved access to shared memory for multi-tasking VxWorks applications. Our experimental results show that our tool can effectively reply multi-core real-time VxWorks applications with reasonable overhead.
A Comparison Of Dynamic Branch Predictors That Use Two Levels Of Branch History

Recent attention to speculative execution as a mechanism for increasing performance of single instruction streams has demanded substantially better branch prediction than what has been previously available. We [1,2] and Pan, So, and Rahmen [4] have both proposed variations of the same aggressive dynamic branch predictor for handling those needs. We call the basic model Two-Level Adaptive Branch Prediction; Pan, So, and Rahmeh call it Correlation Branch Prediction. In this paper, we adopt the terminology of [2] and show that there are really nine variations of the same basic model. We compare the nine variations with respect to the amount of history information kept. We study the effects of different branch history lengths and pattern history table configurations. Finally, we evaluate the cost effectiveness of the nine variations.
Adaptive interference cancellation in circular arrays with radial basis function neural networks

A new neural network based approach to the problem of adaptive interference nulling using circular arrays is presented. In modern cellular, satellite mobile communications systems and in GPS systems, both desired and interfering signals change their directions continuously. This paper develops a fast tracking system to constantly track the users, and then adapt the radiation pattern of the antenna to direct multiple narrow beams to desired users and nulls to sources of interference. In the approach suggested here, the computation of the optimum weights is viewed as a mapping problem which can be modeled using a three-layer Radial Basis Function Neural Networks (RBFNN) trained with input/output pairs. The results obtained from this network are in excellent agreement with the Wiener solution. It was found that networks implementing these functions are successful in tracking mobile users as they move across the antenna's field of view.
Cholinergic control of growth hormone (GH) responses to GH‐releasing hormone in insulin dependent diabetics: evidence for attenuated hypothalamic somatostatinergic tone and decreased GH autofeedback

OBJECTIVE We have investigated the effects of cholinergic modulation with pirenzepine and pyridostigmine and of GH pretreatment on the subsequent GH response to a maximal stimulatory dose of GH‐releasing hormone (GHRH) in patients with insulin dependent diabetes mellitus (IDDM). We have also investigated the relationship between the differences in metabolic control and other parameters of disease state with the differences in GH responses in IDDM.
Internet-connected high-throughput and high-resolution three-dimensional tissue scanner to enable large-scale automated histology

This paper introduces a new high-throughput and high-resolution three dimensional tissue scanner with an Internet-connected 3D virtual microscope for large scale automated histology. This instrument is based on a 3D tissue imaging method called Knife Edge Scanning Microscopy (KESM). A prototype instrument was designed and built based on this technology to scan various tissue samples using mouse brain and octopus brain. The new system of our design improves on the first prototype in multiple design aspects and reduces the instrument footprint and cost. We have also improved the controller software to be scalable for multiple instruments and to have a web-based interface. This new instrument allows verified users to access the microscope from anywhere on the globe using an application authentication framework.
CFHTLenS: testing the laws of gravity with tomographic weak lensing and redshift-space distortions

Dark energy may be the first sign of new fundamental physics in the Universe, taking either a physical form or revealing a correction to Einsteinian gravity. Weak gravitational lensing and galaxy peculiar velocities provide complementary probes of general relativity, and in combination allow us to test modified theories of gravity in a unique way. We perform such an analysis by combining measurements of cosmic shear tomography from the Canada–France–Hawaii Telescope Lensing Survey (CFHTLenS) with the growth of structure from the WiggleZ Dark Energy Survey and the Six-degree-Field Galaxy Survey, producing the strongest existing joint constraints on the metric potentials that describe general theories of gravity. For scale-independent modifications to the metric potentials which evolve linearly with the effective dark energy density, we find present-day cosmological deviations in the Newtonian potential and curvature potential from the prediction of general relativity to be ΔΨ/Ψ = 0.05 ± 0.25 and ΔΦ/Φ = −0.05 ± 0.3, respectively (68 per cent confidence limits).
Problems of Protohistoric Iran as Seen from Hasanlu

THE essay which follows has been prompted by the concurrence of three circumstances. First, there is the wish to honor the memory of Erich F. Schmidt whose important excavations during the 1930's created the University Museum's Iranian collection and established its continuing interest in Iran as a field of study. Second, there is the publication of Roman Ghirshman's major book The Arts of Ancient Iran (1964), which includes chapters discussing northwestern Iran based on work done prior to 1957. Third, there is the fact that the Hasanlu Project of the University Museum and the Metropolitan Museum of Art has now completed eight seasons of excavations in Azerbaijan and Kurdistan2 and is now in a position to begin a summing up of its work at Hasanlu, Ziwiyeh, and elsewhere. The moment seems appropriate, therefore, to attempt to summarize the archeological pattern of northwestern Iran as it has emerged since 1957 in relation to the protohistoric problems of that area. The important protohistoric sites at which excavations have been carried out in the recent past include Geoy Tepe, southeast of Rezaiyeh on the west shore of Lake Urmia (Burton Brown, 1951); Hasanlu (Crawford, 1960; Dyson, 1957-1964) and Agrab Tepe (1964, unpublished) in the Solduz valley east of the Kel-i-Shin pass and southwest of Lake Urmia; Yanik Tepe on the northeast shore of Lake Urmia (Burney, 1962, 1963, 1964); Ziwiyeh in central Kurdistan (1964, unpublished); Zendan-i-Suleiman, east of Ziwiyeh (Naumann, 1960, 1964; Oehler, 1962, 1963; Von der Osten, 1961); Marlik Tepe on the route from the southwestern Caspian shore to the plateau (Negahban, 1962, 1964); and Khorvin, about forty miles west of Teheran (Vanden Berghe, 1964). In discussing the discoveries made at these sites the following archeological periods are based on the stratigraphically established sequence at Hasanlu dated by a relative chronology based in so far as possible on typological comparisons. To this basic structure radiocarbon dates have been added as independent evidence.
Essays on macroeconomic fluctuations

La ultima recesion economica global y la actual crisis de endeudamiento en la Union Europea han incrementado notablemente el interes por entender los origenes y los mecanismos subyacentes liderando la propagacion de recesiones. Dado que esta informacion puede ser util para mitigar los efectos adversos de los episodios contractivos a traves de apropiadas politicas de estabilizacion, investigadores academicos y responsables de la politica economica han empezado a observar atentamente la desagregacion del ciclo economico con el objetivo de explorar los tipos de interconexiones predominantes entre sub-economias, a nivel regional. Esta tesis doctoral se enfoca en analizar algunos aspectos de las fluctuaciones macroeconomicas, tales como los origenes, la propagacion y el pronostico de las recesiones economicas, junto con la interaccion entre ciclos economicos reales y nominales, ademas del pronostico en tiempo real de la produccion en una economia en terminos nominales. Los enfoques metodologicos usados para evaluar dichas cuestiones se basan fundamentalmente en la unificacion entre dos conceptos fundamentales. Primero, las dos caracteristicas que definen a los ciclos economicos, comovimientos y no-linealidades. Segundo, el grado y tipo de interconexion entre un conjunto de sub-economias que pertenecen a un ciclo economico desagregado por medio del analisis de redes.
Runtime failure rate targeting for energy‐efficient reliability in chip microprocessors

Technology scaling is having an increasingly detrimental effect on microprocessor reliability, with increased variability and higher susceptibility to errors. At the same time, as integration of chip multiprocessors increases, power consumption is becoming a significant bottleneck. To ensure continued performance, growth of microprocessors requires development of powerful and energy‐efficient solutions to reliability challenges. This paper presents a reliable multicore architecture that provides targeted error protection by adapting to the characteristics of individual cores and workloads, with the goal of providing reliability with minimum energy. The user can specify an acceptable reliability target for each chip, core, or application. The system then adjusts a range of parameters, including replication and supply voltage, to meet that reliability goal. In this multicore architecture, each core consists of a pair of pipelines that can run independently (running separate threads) or in concert (running the same thread and verifying results). Redundancy is enabled selectively, at functional unit granularity. The architecture also employs timing speculation for mitigation of variation‐induced timing errors and to reduce the power overhead of error protection. On‐line control based on machine learning dynamically adjusts multiple parameters to minimize energy consumption. Evaluation shows that dynamic adaptation of voltage and redundancy can reduce the energy delay product of a chip multiprocessor by 30 − 60% compared with static dual modular redundancy. Copyright © 2012 John Wiley & Sons, Ltd.
Using SPM normalization for lesion analysis in spatial neglect.

Traditionally, the neglect syndrome has been associated with damage to the right inferior parietal lobule (IPL) and the right temporoparietal junction (Heilman et al ., 1983; Vallar and Perani, 1986). Thus, it was surprising when a recent study found that the centre of lesion overlap covered the right superior temporal gyrus and planum temporale, suggesting that the superior temporal cortex rather than the inferior parietal lobule is the critical substrate for spatial neglect in humans (Karnath et al ., 2001). In that study, the authors used a new tool for lesion analysis (MRIcro; www.mricro.com), which allows more precise lesion localization than ever before. Lesions are mapped manually on a T1‐weighted template MRI that is aligned with stereotaxic space (Rorden and Brett, 2000). The template scan provides various anatomical landmarks for precisely plotting the size and localization of the lesion. Moreover, automatic three‐dimensional rendering of the lesion data derived from the transverse slices is available (Rorden and Brett, 2000). This reduces significantly the uncertainty brought in by the paper‐and‐pencil procedures used in previous anatomical studies on spatial neglect (Heilman et al ., 1983; Vallar and Perani, 1986). In a recent article by Mort et al . (2003), the authors noted that the lesions in the study of Karnath et al . (2001) were still demarcated by hand onto standard template images. To overcome this limitation, Mort et al . (2003) used a lesion analysis method that did not rely on the manual transfer of lesions to standard template slices, employing a technique in which the location of the lesion is drawn directly onto the patient’s own MRI scan, and both the scan and the lesion shape are then mapped into stereotaxic space using an automated normalization process (Brett et al ., 2001). This procedure avoids the need for …
Using Mobile Knowledge Management on WirelessNetwork: Perceived Self-Efficacy

Through the wireless network, the important knowledge management is quickly acquired the right knowledge using mobile devices. It can be increased self belief and work efficiency. The recent years study show that perceived ease of use and perceived usefulness constructs of technology acceptance model have been considered important in determining the individuals' acceptance and use of IT. In this study, we will introduce the self-efficacy as a new factor that reflects the characteristic of the mobile knowledge management. This paper addresses why users can be used mobile knowledge management and how user's using is affected by the self-efficacy. The results showed that the research model mediated the usage behavior intentions even in the mobile knowledge management through the wireless network environment.
Chapter 2 Cellular electrophysiology : modeling and simulation

All cells have a difference in voltage across the cell membrane. This is the so-called membrane potential. Some cells, such as neurons and muscle cells, use the membrane potential as a signal. In that case, a cell may be stimulated by application of a small current during a short time period. If the current is sufficiently strong, the membrane potential goes through a large excursion, which is called an action potential, before returning to its resting value. Action potentials are used as signaling mechanism in the brain and to initiate muscular contraction. Cells that are able to generate an action potential are excitable. Examples of excitable cells are neurons, cardiac cells, and smooth and skeletal muscle cells. By establishing electrical connections between the cells, action potentials can propagate through a network of connected cells. Electrical connections between neurons are usually established via synapses, while cardiac muscle cells are electrically connected through so-called gap junctions [5].
Cav1.2 and Cav1.3 L‐type calcium channels independently control short‐ and long‐term sensitization to pain

L‐type calcium channels in the CNS exist as two subunit forming channels, Cav1.2 and Cav1.3, which are involved in short‐ and long‐term plasticity. We demonstrate that Cav1.3 but not Cav1.2 is essential for wind‐up. These results identify Cav1.3 as a key conductance responsible for short‐term sensitization in physiological pain transmission. We confirm the role of Cav1.2 in a model of long‐term plasticity associated with neuropathic pain. Up‐regulation of Cav1.2 and down‐regultation of Cav1.3 in neuropathic pain underlies the switch from physiology to pathology. Finally, the results of the present study reveal that therapeutic targeting molecular pathways involved in wind‐up may be not relevant in the treatment of neuropathy.
Influence of overanxious disorder of childhood on the expression of anorexia nervosa.

OBJECTIVE Childhood anxiety often precedes the onset of anorexia nervosa (AN) and may mark a liability to the emergence of an eating disorder for some women. This study investigates the prevalence of overanxious disorder (OAD) among women with AN and explores how OAD impacts AN symptoms and personality traits. METHOD Participants were 637 women with AN who completed an eating disorders history, the Structured Clinical Interview for DSM-IV Axis I Disorders, and assessments for childhood anxiety, eating disorder attitudes, and associated personality traits. RESULTS Of 249 women (39.1%) reporting a history of OAD, 235 (94.4%) met criteria for OAD before meeting criteria for AN. In comparison to those without OAD, women with AN and OAD self-reported more extreme personality traits and attitudes and they engaged in more compensatory behaviors. CONCLUSION Among individuals with AN, those entering AN on a pathway via OAD present with more severe eating disorder pathology.