Miracle-dz/UniFAR-FTUs huggingface dataset:
Health Promotion Attitudes and Practices of Texas Nurse Practitioners

Purpose The Purpose of this descriptive cross‐sectional survey was to examine the health promotion attitudes and practices of Texas nurse practitioners (NPs). Data Sources Original research utilizing the Health Promotion Practices of Nurse Practitioners Instrument developed by the researcher and completed 442 Texas NPs. Conclusions Overall, Texas NPs have positive attitudes toward health promotion and are supportive of health promotion practices. However, the findings this study indicate that improvement can made in the adoption of certain health promotion practices. Implications for Practice The growing number of NPs providing care patients can significantly impact public health through consistent health promotion in clinical practice.
An Overview of BPPT’s Indonesian Language Resources

This paper describes various Indonesian language resources that Agency for the Assessment and Application of Technology (BPPT) has developed and collected since mid 80’s when we joined MMTS (Multilingual Machine Translation System), an international project coordinated by CICC-Japan to develop a machine translation system for five Asian languages (Bahasa Indonesia, Malay, Thai, Japanese, and Chinese). Since then, we have been actively doing many types of research in the field of statistical machine translation, speech recognition, and speech synthesis which requires many text and speech corpus. Most recent cooperation within ASEAN-IVO is the development of Indonesian ALT (Asian Language Treebank) has added new NLP tools.
A New Approach for Dispersion Parameters

This paper presents a new approach to identify and estimate the dispersion parameters for bivariate, trivariate and multivariate correlated binary data, not only with scalar value but also with matrix values. For this direction, we present some recent studies indicating the impact of over-dispersion on the univariate data analysis and comparing a new approach with these studies. Following the property of McCullagh and Nelder [1] for identifying dispersion parameter in univariate case, we extended this property to analyze the correlated binary data in higher cases. Finally, we used these estimates to modify the correlated binary data, to decrease its over-dispersion, using the Hunua Ranges data as an ecology problem.
Detection of disk drug orientation for disk diffusion susceptibility testing

At the present, the microbiological infection is one of the most significant issues in the global. The medical laboratory diagnosis, microbiology, is the most popular way to identify a type of microbiology which is infected-source. Moreover, there are a few microbial prognoses to support a medical treatment. It is effectively controlled by antibiotic management such as Disk diffusion antimicrobial susceptibility testing, Kirby Bauer AST. This technique is well-known in all microbiological laboratories. This study was the development of interpreting system for antimicrobial susceptibility testing by the disc diffusion technique with automatically measures and interprets inhibition zone diameter. The operated system has comprised electronic part; optical devices, video capture part, and software which manages and analyses all processes. The technology of this system was uncomplicated, effective cost and potential automated test. The disk detected-process and measured process; pre-process, were operated via image processing steps such as image smoothening, edge detection, template matching. The output of this part was sent to the next sections, data correction, interpretation and report, respectively.
The potential therapeutic value for bereaved relatives participating in research: An exploratory study

Abstract Objective: Conducting research with the bereaved presents an immediate ethical challenge, as they are undoubtedly a vulnerable group, associated with high levels of distress and susceptible to both physical and mental health issues. A comprehensive understanding of the potential therapeutic benefits for bereaved relatives participating in palliative care research is limited, and therefore the ethics of engaging this group remain questionable. Method: This paper describes a secondary analysis of qualitative data collected in the Care of the Dying Evaluation (CODE) project, examining the experiences of patients who died at home. It explores the motivations and potential benefits for bereaved relatives participating in research with reference to the recently developed concepts in bereavement theory. Cognitive interviews were conducted with 15 bereaved relatives and secondary analysis using a content analysis framework was employed to classify the data. Results: The results center around six recurring concepts identified as adaptive in current bereavement theory: an opportunity to share the narrative accounts of the final hours of their relative's life; a search for sense and meaning in loss; an ongoing bond/attachment with the deceased; altruistic motivations; oscillation between loss and restorative orientations; and a sense of resilience. Overall, the participants found that taking part in the research was valuable and that it could be described as offering therapeutic benefits. Significance of results: The need for bereaved relatives to take part in research studies should be encouraged, as they provide an accurate proxy for the patient's experience of end-of-life care while also providing a valuable account of their own perspective as family member and carer. In addition, we highlight the need for ethics committees to be aware of the potential benefits for bereaved relatives participating in research of this kind.
Spatiotemporal electron dynamics in radio-frequency glow discharges: fluid versus dynamic Monte Carlo simulations

A particle-in cell/dynamic Monte Carlo simulation technique was developed to study the spatiotemporal electron dynamics in radio-frequency glow discharges. The electric field profile in a parallel plate one-dimensional geometry was obtained from a self-consistent fluid simulation. Using this profile, the particle-in-cell/dynamic Monte Carlo simulation yielded the spatiotemporal electron velocity distribution function between the electrodes. A strongly electronegative chlorine discharge and an electropositive argon discharge were considered. At a pressure of 100 mTorr, the distribution function was non-Maxwellian except at the midgap of the chlorine discharge. The tail of the distribution was strongly modulated inside the sheath. Electron 'pile-ups' near the walls, charge double layers and negative plasma potential during part of the cycle were observed in the electronegative discharge at 13.56 MHz. Time-average results from the particle-in-cell/dynamic Monte Carlo simulation matched the fluid simulation favourably, even at a local Knudsen number Kn approximately=1, with differences confined mainly to the volume around the plasma/sheath interface.
Declarative and Procedural Learning in Individuals With Subclinical Obsessive-Compulsive Symptoms

Previous neuropsychological research suggests that psychometrically defined subclinical obsessive-compulsive (OC) individuals perform worse than non-OC controls on specific tests of executive functioning. This study aimed to extend these findings by comparing the performance of 25 subclinical OC and 28 non-OC control subjects on measures of declarative learning (Rey Auditory Verbal Learning Test), motor procedural learning (star maze), spatial problem solving (single administration of the 3-disk version of the Tower of Hanoi; TH3), and “cognitive” procedural learning (repeated administrations of the 4-disk version of the Tower of Hanoi; TH4). In addition, the subjects were administered measures of general intelligence, anxiety and depression. No between-group differences were observed on measures of declarative and motor procedural learning. Subclinical OC subjects needed significantly more moves than controls to solve TH3, suggesting poorer spatial problem solving ability. A significant group × trial interaction on the TH4 suggested reduced cognitive skill acquisition in the subclinical OC group. However, performance on TH3 and TH4 was significantly correlated in the OC group but not in the control group, suggesting that the suboptimal acquisition of cognitive skills among subclinical OC subjects is more likely to be related to inefficient spatial problem solving strategies than to a cognitive procedural learning deficit per se. These results replicate and expand upon previous findings and support a dimensional model of Obsessive-Compulsive Disorder.
Application of audio fingerprinting to Neonatal EEG

A clinical neurophysiologist must recognize patterns in EEG signals to evaluate the health of a patient's brain activity. Rare or unusual patterns may take time to correctly identify. The ability to automatically assist this recall would be beneficial in ensuring that appropriate measures could be taken in a timely fashion. Audio fingerprinting is a method used to identify songs using only a snippet of the song. Fingerprints are extracted from a sub-section of the song and matched against a database of previously computed fingerprints. In this paper, a fingerprint quantization technique is implemented on neonatal EEG data to attempt to identify sections of EEG data when only seeing a sub-section of the data. The impact of signal distortions is investigated and results from a database of one hour recordings from 40 newborns are presented.
Comercio y mercado en Mesoamérica: apuntes metodológicos para su análisis arqueológico

Mesoamerica fue uno de los nucleos autonomos del nacimiento de la agricultura, desarrollo de sociedades complejas de tipo estatal y maduracion de instituciones comerciales en el mundo de la Antiguedad. Aunque tanto el comercio como el mercado han sido considerados importantes mecanismos de integracion socioeconomica en la Mesoamerica Posclasica (1150 – 1521), no disponemos de un corpus adecuado de recursos metodologicos ni teoricos con los que afrontar su investigacion en etapas culturales anteriores. El presente trabajo contribuye con una sistematizacion de las actuales tendencias en torno a la exploracion arqueologica del comercio mesoamericano focalizando la atencion en tres niveles: produccion y adquisicion, grados de distribucion y patrones de consumo.
Epstein-Barr Virus Nuclear Antigen 3 C Augments Mdm 2-Mediated p 53 Ubiquitination and Degradation by Deubiquitinating Mdm 2

Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA3C) is one of the essential latent antigens for primary B-cell transformation. Previous studies established that EBNA3C facilitates degradation of several vital cell cycle regulators, including the retinoblastoma (pRb) and p27 proteins, by recruitment of the SCF E3 ubiquitin ligase complex. EBNA3C was also shown to be ubiquitinated at its N-terminal residues. Furthermore, EBNA3C can bind to and be degraded in vitro by purified 20S proteasomes. Surprisingly, in lymphoblastoid cell lines, EBNA3C is extremely stable, and the mechanism for this stability is unknown. In this report we show that EBNA3C can function as a deubiquitination enzyme capable of deubiquitinating itself in vitro as well as in vivo. Functional mapping using deletion and point mutational analysis showed that both the Nand C-terminal domains of EBNA3C contribute to the deubiquitination activity. We also show that EBNA3C efficiently deubiquitinates Mdm2, an important cellular proto-oncogene, which is known to be overexpressed in several human cancers. The data presented here further demonstrate that the N-terminal domain of EBNA3C can bind to the acidic domain of Mdm2. Additionally, the N-terminal domain of EBNA3C strongly stabilizes Mdm2. Importantly, EBNA3C simultaneously binds to both Mdm2 and p53 and can form a stable ternary complex; however, in the presence of p53 the binding affinity of Mdm2 toward EBNA3C was significantly reduced, suggesting that p53 and Mdm2 might share a common overlapping domain of EBNA3C. We also showed that EBNA3C enhances the intrinsic ubiquitin ligase activity of Mdm2 toward p53, which in turn facilitated p53 ubiquitination and degradation. Thus, manipulation of the oncoprotein Mdm2 by EBNA3C potentially provides a favorable environment for transformation and proliferation of EBV-infected cells.
Investigations on the effect of the ruminal N-balance on rumen metabolism, urea content in blood serum and milk as well as some liver parameters of lactating cows

Abstract Seven dairy cows fitted with ruminal and duodenal cannulae were used to investigate the influence of the amount of ruminally available N (Ruminal N-Balance, RNB) on the rumen metabolism and to answer the question on the lowest N-amount in the rumen, without negative effects on the fermentation. Animals were fed a ration on the basis of 7.9 kg corn silage and 7.2 kg concentrates related to dry matter, intended to meet the animals mean NEL and protein requirements. RNB amounted to −0.6 g/MJ ME in the basis ration. The other 3 rations were adjusted to RNB-values of −0.3, 0 and +0.3 g/MJ ME by urea supplements in the concentrates. The increase in RNB resulted in higher NH3-N concentrations in the rumen fluid and in the duodenal digesta and higher urea concentrations in the blood and milk. The significantly highest amount of protein at the duodenum was detected when RNB showed an equilibrium (RNB = 0). The efficiency of microbial protein (MP) synthesis (g MP/kg fermented organic matter) was the same, g MP/d and g MP/MJ ME were significantly lower with RNB = −0.6 g/MJ ME as compared to RNB = 0. The group with the lowest RNB showed the highest level of feed protein degradation as well as the lowest organic matter, NDF and ADF fermentation. An effect on cholesterol, total bilirubin and γGT due to different RNB was not detected. The activities of GLDH and AST were highest when the RNB was −0.6 g/MJ ME. From the results, it can be concluded that significantly negative effects on rumen fermentation occur when RNB-values are below −0.3 g/MJ ME. However, a positive RNB did not increase the degradation and synthesis capacity of the rumen micro-organisms as compared to RNB = 0.
A Computational Study to Find an Optimal RRR Value for a 1.5-T Persistent-Mode Conduction-Cooled MgB 2 MRI Magnet From a Quench Protection Point of View

The effect of magnetoresistance, magnetothermal conductivity (MTC), and RRR value on the active quench protection of a persistent-mode conduction-cooled 1.5 T MgB<sub>2</sub> superconducting magnet is studied using numerical simulation. It is found that inclusion of magnetoresistance in the simulation can significantly decrease the calculated maximum temperature reached in this magnet during a quench, e.g., by 9 K for <italic>RRR</italic> = 100. The inclusion of both magnetoresistance and MTC similarly decreases the peak temperature, but by a smaller amount, e.g., by 7 K for <italic>RRR</italic> = 100. Using copper with a lower RRR value can also significantly decrease the peak temperature reached in this magnet, e.g., by 16 K for <italic>RRR</italic> = 50 as compared to <italic>RRR</italic> = 200. However, decreasing the RRR value to much less than 50 results in a significantly higher voltage, e.g., decreasing the RRR value from 50 to 10 results in a 1000 V increase. A RRR value between 50 and 100 may provide a good balance.
SOCIAL AND STYLISTIC VARIATION IN THE ORDER OF AUXILIARY AND NONFINITE VERB IN DEPENDENT CLAUSES IN EARLY NEW HIGH GERMAN

Syntagms consisting of three or more verbal forms pattern quite dififerently at this time than do these two-part constructions and consequently are not considered here. »Dependent clause«, another controversial category, is used here äs a cover term for clauses of the following form: »subordinating conjunction« or relative pronoun + * ° more constituents + finite verb (+ one or more constituents). Truncated dependent clauses without introductory morpheme, such äs Die neühen hayratt, du mir nacheinander geschrieben hast (Balthasar Paumgartner, p. 24), are used by a few writers and are included in these data. To be included in the data base the auxiliary and nonfinite form must be contiguous, äs in examplee (5)a. -f. below:
Do Web-based Mental Health Literacy Interventions Improve the Mental Health Literacy of Adult Consumers? Results From a Systematic Review

Background Low levels of mental health literacy (MHL) have been identified as an important contributor to the mental health treatment gap. Interventions to improve MHL have used traditional media (eg, community talks, print media) and new platforms (eg, the Internet). Evaluations of interventions using conventional media show improvements in MHL improve community recognition of mental illness as well as knowledge, attitude, and intended behaviors toward people having mental illness. However, the potential of new media, such as the Internet, to enhance MHL has yet to be systematically evaluated. Objective Study aims were twofold: (1) To systematically appraise the efficacy of Web-based interventions in improving MHL. (2) To establish if increases in MHL translated into improvement in individual health seeking and health outcomes as well as reductions in stigma toward people with mental illness. Methods We conducted a systematic search and appraisal of all original research published between 2000 and 2015 that evaluated Web-based interventions to improve MHL. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were used to report findings. Results Fourteen studies were included: 10 randomized controlled trials and 4 quasi-experimental studies. Seven studies were conducted in Australia. A variety of Web-based interventions were identified ranging from linear, static websites to highly interactive interventions such as social media games. Some Web-based interventions were specifically designed for people living with mental illness whereas others were applicable to the general population. Interventions were more likely to be successful if they included “active ingredients” such as a structured program, were tailored to specific populations, delivered evidenced-based content, and promoted interactivity and experiential learning. Conclusions Web-based interventions targeting MHL are more likely to be successful if they include active ingredients. Improvements in MHL see concomitant improvements in health outcomes, especially for individuals with mild to moderate depression. The most promising interventions suited to this cohort appear to be MoodGYM and BluePages, 2 interventions from Australia. However, the relationship between MHL and formal and informal help seeking is less clear; self-stigma appears to be an important mediator with results showing that despite improvements in MHL and community attitudes to mental illness, individuals with mental illness still seek help at relatively low rates. Overall, the Internet is a viable method to improve MHL. Future studies could explore how new technology interfaces (eg, mobile phones vs computers) can help improve MHL, mental health outcomes, and reduce stigma.
Bovine Viral Diarrhea Virus Entry Is Dependent on Clathrin-Mediated Endocytosis

ABSTRACT Cellular mechanisms of bovine viral diarrhea virus (BVDV) entry in MDBK cells were investigated. Chloroquine, bafilomycin A1, or ammonium chloride inhibited BVDV infection, indicating that an acidic endosomal pH is required for BVDV entry. The tyrosine kinase inhibitor genistein partially inhibited BVDV infection at a postentry step, whereas BVDV entry was strongly inhibited by chlorpromazine or by the overexpression of a dominant-negative form of EPS15, a protein essential for the formation of clathrin-coated vesicles at the plasma membrane. Together, these data indicate that BVDV infection requires an active clathrin-dependent endocytic pathway.
Recurrent Tumor vs Radiation Effects after Gamma Knife Radiosurgery of Intracerebral Metastases: Diagnosis with PET‐FDG

Objective Our objective was to differentiate radiation effects from tumor progression in metastases stereotaxically irradiated with the multicobalt unit (Gamma Knife). Materials and Methods Eleven patients with stereotaxically irradiated cerebral metastases were examined with PET using [18F]fluorodeoxyglucose (FDG) to differentiate recurrent tumor from radiation effects. Results Six patients had increased uptake of FDG, and clinical, radiological, and pathological findings confirmed the diagnosis of recurrent metastases. These patients had an unfavorable prognosis and were all dead within 54 weeks after radiosurgery. Five patients had lesions without an increased accumulation of FDG. Four of these patients were alive after a total follow-up of 1.7 years, while one patient died of a peptic ulcer 56 weeks after radiosurgery. Conclusion Positron emission tomography with FDG was of obvious prognostic value in this small series of patients and was clearly superior to CT and MR in the distinction between tumor recurrence and radiation effects (verified necrosis in one case).
Acute myeloid leukemia; decided victories, disappointments, and detente: an historical perspective.

See the related ASH 50th Anniversary Review articles under the ACUTE AND CHRONIC LEUKEMIAS section of the publication ASH 50th Anniversary Reviews: A Salute to the American Society of Hematology. John Hughes Bennett (1812-1875) was only 33 years old and Rudolf Virchow (1821-1902) only 24 in 1845 when each described patients at autopsy with two common features: an enlarged spleen and a change in the color and consistency of the blood. Although Bennett believed the blood contained purulent material, Virchow was not convinced. He described the finding as white blood or “leukemia,” a term attributed to him in 1847. It was Nobel Laureate Paul Ehrlich (1854-1915) in 1891 who introduced new methods for staining blood cells and as a result confirmed that granulocytes were the predominant cell type in the myeloid form of leukemia.
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

High Mobility Group 1 protein (HMGB1) is a chromatin component that, when leaked out by necrotic cells, triggers inflammation. HMGB1 can also be secreted by activated monocytes and macrophages, and functions as a late mediator of inflammation. Secretion of a nuclear protein requires a tightly controlled relocation program. We show here that in all cells HMGB1 shuttles actively between the nucleus and cytoplasm. Monocytes and macrophages acetylate HMGB1 extensively upon activation with lipopolysaccharide; moreover, forced hyperacetylation of HMGB1 in resting macrophages causes its relocalization to the cytosol. Cytosolic HMGB1 is then concentrated by default into secretory lysosomes, and secreted when monocytic cells receive an appropriate second signal.
Intonation in the processing of contrast meaning in French: An eye-tracking study

Listeners rapidly process tonal composition and pitch accent placement within an utterance to create expectations about its pragmatic meaning and information structure. It is still unknown whether the nuclear pitch accent alone or a combination of pitch accent and the following edge tone are needed in order to process intonational meaning in French. This study investigates the online comprehension of the French (L)H*L% rise-fall “implication” contour, which evokes a contrast meaning. Twenty-nine speakers participated in an eye-tracking experiment. The critical stimuli were sentences whose interpretation could be anticipated by successfully processing the implied meaning evoked by the (L)H*L% rise-fall contour on the critical word (hereafter CW). The results showed that participants are able to associate the implication contour with a contrast meaning, and that they start doing this only after the H* peak of the rise-fall intonation movement has been processed, hence when part of the L% falling movement has been perceived.