Miracle-dz/UniFAR-FTUs huggingface dataset:
Implementation strategies in software development - Case XBRL

The main objective of this study is to identify and describe the ways in which companies approach implementing inter-organizational software functionalities into their software products and services and to identify the factors that affect their choice of a software implementation strategy. The study is a descriptive multiple case study that focuses on four companies that are all doing a similar XBRL functionality implementation at the same time. The theoretical framework of the study consists of multiple factors, out of which network effect and path dependence are the most prominent theories that are used to guide the case study design. The reviewed literature categorizes software implementation strategies according to how deeply the new functionality is integrated into existing systems, categorizing software implementations into bolt-on, built-in, and deeply embedded implementation strategies. The findings from the case study indicate support for this kind of categorization in the observed cases, although the categories should be considered to be more of a continuum than set of discrete classes. The results of the case study also indicate that, in the cases that were observed, network effects and path dependence play a role in the software implementation strategy selection but a significant factor in the implementation strategy decisions is also the uncertainty of the future adoption, development, and use of the technology in question. In an inter-organizational context, companies weigh in the perceived benefits of a software implementation against their confidence in the future use of that technology, forming an estimate of the expected value of the future benefit of the software implementation. This expected value will then in turn factor into the software implementation strategy decision and partly contribute to how deeply the company is willing to integrate the functionality into their existing systems.
Apex Lake: A Framework for Enabling Smart Orchestration

The introduction of a Software-defined infrastructures brings additional challenges to the management of cloud infrastructure. With the impending convergence of telecommunications and cloud infrastructures, datacenters become an essential part of an overall integrated environment. The potential scale of such environments has significant implications as traditional orchestration approaches cannot scale appropriately. However, the combination of infrastructure topology, fine-grained operational data and advanced analytics, has the potential to deliver a scalable approach to facilitate orchestration and resource management. In this paper we introduce Apex Lake, a framework designed to address the question of "how to efficiently define and maintain a physical and logical resource and service landscape enriched by operational data, to support orchestration for optimized service delivery? " We also demonstrate with a use-case illustrating how functionalities provided by Apex Lake can be used dealing with performance anomalies.
Detecting anomalies in high-performance parallel programs

Message passing interface (MPI) is an effective programming technique for implementing parallel programs for distributed computation. As these applications run, a number of different types of irregularities can occur including those that result from intrusions, user misbehavior, corrupted data, deadlocks or failure of cluster components. We perform a comparison of different artificial intelligence (AI) techniques that can be used to implement a lightweight monitoring and detection system for parallel applications on a cluster of Linux workstations. We study the accuracy and performance of deterministic and stochastic algorithms when we observe the flow of function library and OS system calls of parallel programs written with MPI. We demonstrate that monitoring of MPI programs can be achieved with high accuracy and in some cases with a 0% false positive rate in real-time, and we show that the added computational load on each node is small. Finally we demonstrate that simple deterministic methods perform poorly when the program flow grows in size and variety, and that more complex methods are required.
Marine Low Molecular Weight Natural Products as Potential Cancer Preventive Compounds

Due to taxonomic positions and special living environments, marine organisms produce secondary metabolites that possess unique structures and biological activities. This review is devoted to recently isolated and/or earlier described marine compounds with potential or established cancer preventive activities, their biological sources, molecular mechanisms of their action, and their associations with human health and nutrition. The review covers literature published in 2003–2013 years and focuses on findings of the last 2 years.
L2 primes L1 – translation priming in LDT and semantic categorisation with unbalanced bilinguals*

ABSTRACT The aim of the study was to test whether proficient L2 users living in an L1-dominant environment would exhibit significant L2–L1 translation priming in a lexical decision task (LDT) and in a sematic categorisation task (SCT). Only a few previous studies have found significant L2–L1 priming in LDT whereas significant results have often been recorded in SCT but only for exemplars. In the present study, significant L2–L1 priming has been found in both tasks. Furthermore, in SCT L2–L1 priming was significant not only for exemplars but also for non-exemplars. However, the effect was stronger for exemplars than for non-exemplars. Such a pattern of results is discussed with respect to current models of lexical representation and language processing in bilinguals.
Stressors, coping and depression in haemodialysis patients.

BACKGROUND Depression is common in persons receiving outpatient haemodialysis, but little work has been done to explore the variables associated with depression. AIMS The primary purposes of this study were to (i) examine relationships among stressors, coping and depression and (ii) test the mediating role of coping. DESIGN/METHODS Data were collected at two points in time, three months apart in 1995/1996. The final convenience sample at Time 2 was 86 participants from two United States midwestern, inner-city dialysis units. Structured interviews were conducted using the Centre for Epidemiologic Studies Depression Scale, the haemodialysis stressor scale (HSS) and the coping strategy indicator. RESULTS At Time 1 more psychosocial stressors were associated with greater use of problem-solving, social-support and avoidance coping. Both avoidance coping and more psychosocial stressors at Time 1 were related to depression at Time 2. Finally, avoidance coping was found to explain much of the relationship between psychosocial stressors and depression. CONCLUSIONS Research is now needed that explicates the causal relationships among stress, coping and depression in haemodialysis patients.
An extended interior-point method for transmit beamforming in multi-group multicasting

We address the problem of transmit beamforming to multiple cochannel multicast groups where the total transmitted power is minimized subject to quality-of-service (QoS) constraints at the receivers. The iterative second-order cone programming (SOCP) approach recently proposed in [2] is a powerful tool to solve this problem and has certain advantages over other state-of-the-art techniques like the semidefinite relaxation (SDR) approach. However, we show in this paper that its computational complexity is unnecessarily high. Therefore, we propose to eliminate the superfluous part of its computational effort by combining the concept of the iterative SOCP method with that of interior-point methods. Computer simulations show that by this means, we can substantially reduce the computational complexity of the iterative SOCP method while preserving its good performance.
From Individual Human Agents to Crowds

In this paper, we ﬁrst try to identify which mechanisms are to be simulated in order to implement truly virtualhumans or actors. Starting from a structure linking perception, emotion, behaviour, and action, we empha-size the central concept of autonomy and introduce the concept of Levels of Autonomy. Finally, we proposea new abstraction for the speciﬁcation of behaviours in complex virtual environment simulations involvinghuman agents, groups of agents, and interactive objects endowed with different levels of autonomy.
Analysis of Stainless Steel Bipolar Plates Micro-Stamping Processes

Bipolar plate is one of the key components of proton exchange membrane fuel cells (PEMFC). Since the production costs of traditional graphite bipolar plates are very expensive and need a few millimeters thickness over the space, the resulting metal bipolar plate not only reduces the cost of such a bipolar plate, the thickness can also be reduced to micron range. This study aims to explore the application of micro-stamping technology to produce thin metal bipolar plates with the relevant process parameters. Regarding the use of rigid punch on 50μm-thick stainless steel sheet (SUS 304) for micro-channel stamping process in this study, the channel design is 0.8*0.75mm. Besides, the finite element method and the experimental results are used to analyze the micro-stamping process key parameters. In this study, traditional material model and the scale-factor modified material model are used for simulation. The experimental results verified by the modified material model are more realistic to products and have better similarity, as the punch load is relatively small. The results demonstrate that the use of micro-stamping production of thin metal bipolar plates could not only reduce the production cost, but could also speed up the process. In this paper, using ULF (updated Lagrangian formulation) concept to establish an elastic-plastic deformation finite element analysis model and using scale-factor to modify the calculation could effectively simulate the micro-stamping process for metal bipolar plates. Streszczenie. Dwubiegunowa plyta jest zasadniczym skladnikiem baterii PEMFC z membranową wymianą protonową. W artykule zaproponowano zastąpienie tradycyjne plyty grafitowej przez plyte oraz opisano technologie mikro-tloczenia w celu uzyskania grubości rzedu mikronow. (Analiza procesu mikrotloczenia stosowane go do otrzymywania stalowych bipolarnych membran o ekstremalnie malych grubościach)
Intracellular localization and trafficking of fluorescein-labeled cisplatin in human ovarian carcinoma cells.

PURPOSE We sought to identify the subcellular compartments in which cisplatin [cis-diamminedichloroplatinum (DDP)] accumulates in human ovarian carcinoma cells and define its export pathways. EXPERIMENTAL DESIGN Deconvoluting digital microscopy was used to identify the subcellular location of fluorescein-labeled DDP (F-DDP) in 2008 ovarian carcinoma cells stained with organelle-specific markers. Drugs that block vesicle movement were used to map the traffic pattern. RESULTS F-DDP accumulated in vesicles and were not detectable in the cytoplasm. F-DDP accumulated in the Golgi, in vesicles belonging to the secretory export pathway, and in lysosomes but not in early endosomes. F-DDP extensively colocalized with vesicles expressing the copper efflux protein, ATP7A, whose expression modulates the cellular pharmacology of DDP. Inhibition of vesicle trafficking with brefeldin A, wortmannin, or H89 increased the F-DDP content of vesicles associated with the pre-Golgi compartments and blocked the loading of F-DDP into vesicles of the secretory pathway. The importance of the secretory pathway was confirmed by showing that wortmannin and H89 increased whole cell accumulation of native DDP. CONCLUSIONS F-DDP is extensively sequestered into vesicular structures of the lysosomal, Golgi, and secretory compartments. Much of the distribution to other compartments occurs via vesicle trafficking. F-DDP detection in the vesicles of the secretory pathway is consistent with a major role for this pathway in the efflux of F-DDP and DDP from the cell.
Improved silencing properties using small internally segmented interfering RNAs

RNA interference is mediated by small interfering RNAs (siRNAs) that upon incorporation into the RNA-induced silencing complex (RISC) can target complementary mRNA for degradation. Standard siRNA design usually feature a 19–27 base pair contiguous double-stranded region that is believed to be important for RISC incorporation. Here, we describe a novel siRNA design composed of an intact antisense strand complemented with two shorter 10–12 nt sense strands. This three-stranded construct, termed small internally segmented interfering RNA (sisiRNA), is highly functional demonstrating that an intact sense strand is not a prerequisite for RNA interference. Moreover, when using the sisiRNA design only the antisense strand is functional in activated RISC thereby completely eliminating unintended mRNA targeting by the sense strand. Interestingly, the sisiRNA design supports the function of chemically modified antisense strands, which are non-functional within the context of standard siRNA designs. This suggests that the sisiRNA design has a clear potential of improving the pharmacokinetic properties of siRNA in vivo.
Associations of Pet Ownership with Wheezing and Lung Function in Childhood: Findings from a UK Birth Cohort

Background Asthma is a heterogeneous condition and differential effects of pet ownership on non-atopic versus atopic asthma have been reported. The aim of this study was to investigate whether pet ownership during pregnancy and early childhood was associated with wheezing from birth to age 7 years and with lung function at age 8 years in a UK population-based birth cohort. Methods Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used to investigate associations of pet ownership at six time-points from pregnancy to age 7 years with concurrent episodes of wheezing, wheezing trajectories (phenotypes) and lung function at age 8 years using logistic regression models adjusted for child’s sex, maternal history of asthma/atopy, maternal smoking during pregnancy, and family adversity. Results 4,706 children had complete data on pet ownership and wheezing. From birth to age 7 years, cat ownership was associated with an overall 6% lower odds of wheezing (OR=0.94 (0.89-0.99)). Rabbit and rodent ownership was associated with 21% (OR=1.21 (1.12-1.31)) and 11% (OR=1.11 (1.02–1.21)) higher odds of wheezing, respectively, with strongest effects evident during infancy. Rabbit and rodent ownership was positively associated with a ‘persistent wheeze’ phenotype. Pet ownership was not associated with lung function at age 8 years, with the exception of positive associations of rodent and bird ownership with better lung function. Conclusions Cat ownership was associated with reduced risk, and rabbit and rodent ownership with increased risk, of wheezing during childhood. The mechanisms behind these differential effects warrant further investigation.
Postnatal ontogeny of glucose homeostasis and insulin action in sheep.

Glucose tolerance declines with maturation and aging in several species, but the time of onset and extent of changes in insulin sensitivity and insulin secretion and their contribution to changes in glucose tolerance are unclear. We therefore determined the effect of maturation on glucose tolerance, insulin secretion, and insulin sensitivity in a longitudinal study of male and female sheep from preweaning to adulthood, and whether these measures were related across age. Glucose tolerance was assessed by intravenous glucose tolerance test (IVGTT, 0.25 g glucose/kg), insulin secretion as the integrated insulin concentration during IVGTT, and insulin sensitivity by hyperinsulinemic-euglycemic clamp (2 mU insulin.kg(-1). min(-1)). Glucose tolerance, relative insulin secretion, and insulin sensitivity each decreased with age (P < 0.001). The disposition index, the product of insulin sensitivity, and various measures of insulin secretion during fasting or IVGTT also decreased with age (P < 0.001). Glucose tolerance in young adult sheep was independently predicted by insulin sensitivity (P = 0.012) and by insulin secretion relative to integrated glucose during IVGTT (P = 0.005). Relative insulin secretion before weaning was correlated positively with that in the adult (P = 0.023), whereas glucose tolerance, insulin sensitivity, and disposition indexes in the adult did not correlate with those at earlier ages. We conclude that glucose tolerance declines between the first month of life and early adulthood in the sheep, reflecting decreasing insulin sensitivity and absence of compensatory insulin secretion. Nevertheless, the capacity for insulin secretion in the adult reflects that early in life, suggesting that it is determined genetically or by persistent influences of the perinatal environment.
The increasing application of multiplex nucleic acid detection tests to the diagnosis of syndromic infections

SUMMARY On 14 January 2013, the US Food and Drug Administration (FDA) announced permission for a multiplex nucleic acid test, the xTAG® Gastrointestinal Pathogen Panel (GPP) (Luminex Corporation, USA), which simultaneously detects 11 common viral, bacterial and parasitic causes of infectious gastroenteritis, to be marketed in the USA. This announcement reflects the current move towards the development and commercialization of detection technologies based on nucleic acid amplification techniques for diagnosis of syndromic infections. We discuss the limitations and advantages of nucleic acid amplification techniques and the recent advances in Conformité Européene – in-vitro diagnostic (CE-IVD)-approved multiplex real-time PCR kits for the simultaneous detection of multiple targets within the clinical diagnostics market.
Dopamine neuron precursors within the developing human mesencephalon show radial glial characteristics

Specification and differentiation of neural precursors into dopaminergic neurons within the ventral mesencephalon has been subject to much attention due to the implication of dopaminergic neurons in Parkinson's disease and the perspective of generating sources of therapeutically active cells to be used for cell replacement therapy for the disease. However, despite intensive research efforts, little is known about the characteristics of the dopamine neuron progenitors in human. We show that the dopamine neuron determinant LMX1a is expressed in the diencephalic and mesencephalic dopaminergic neuron domains during human development. Within the mesencephalon, LMX1a is expressed in the dopaminergic neurons and their progenitors located in the ventricular zone of the floor plate region. Furthermore, the neural progenitors in the developing human ventral mesencephalon have a radial morphology and express the radial glial markers Vimentin and BLBP. These radial glia are mitotic and act as precursors for the dopaminergic neurons. Finally, we show that progenitors isolated from the human ventral mesencephalon maintain their radial glial characteristics and neurogenic capacity after expansion in vitro, making them a promising future source of cells to be used in cell replacement therapy for Parkinson's disease. © 2009 Wiley‐Liss, Inc.
Polyamines Induce Resistance to Cationic Peptide, Aminoglycoside, and Quinolone Antibiotics in Pseudomonas aeruginosa PAO1

ABSTRACT Pseudomonas aeruginosa, a gram-negative bacterium of human pathogens, is noted for its environmental versatility, enormous metabolic capacity, and resistance to antibiotics. Overexpression of the outer membrane protein OprH and increased resistance to polycationic peptide antibiotics (e.g., polymyxin B) mediated by the PhoPQ two-component system on induction of a putative lipopolysaccharide (LPS) modification operon (PA3552-PA3559) have been reported as part of the adaptive responses to magnesium limitation in P. aeruginosa. Induction of the oprH-phoPQ operon and the LPS modification operon by exogenous spermidine was revealed from GeneChip analysis during studies of polyamine metabolism and was confirmed by the lacZ fusions of affected promoters. From the results of MIC measurements, it was found that addition of spermidine or other polyamines to the growth medium increased the MIC values of multiple antibiotics, including polycationic antibiotics, aminoglycosides, quinolones, and fluorescent dyes. MIC values of these compounds in the transposon insertion mutants of oprH, phoP, phoQ, and pmrB were also determined in the presence and absence of spermidine. The results showed that the spermidine effect on cationic peptide antibiotic and quinolone resistance was diminished in the phoP mutant only. The spermidine effect on antibiotics was not influenced by magnesium concentrations, as demonstrated by MICs and oprH::lacZ fusion studies in the presence of 20 μM or 2 mM magnesium. Furthermore, in spermidine uptake mutants, MICs of cationic peptide antibiotics and fluorescent dyes, but not of aminoglycosides and quinolones, were increased by spermidine. These results suggested the presence of a complicated molecular mechanism for polyamine-mediated resistance to multiple antibiotics in P. aeruginosa.
Measurement of Sensitivity Distribution Map of a Ferroelectret Polymer Film

Electromechanical Film (EMFi) is an electroactive ferroelectret polymer film with a special cellular structure. Sensitivity distribution maps of EMFi sensors were measured in this paper. Seven EMFi sensors with evaporated gold electrodes, a size of 55 mm × 55 mm, were measured with a measurement grid spacing of 5 mm. The sensitivity is defined here as the charge generated by the EMFi sensor divided by the force applied to excite the sensor, and this is closely related to piezoelectric d33 coefficient. The sensitivity of EMFi was found to vary in different places of the sensors and between the measured sensors. This is presumably due to the relatively large gas voids and local corona breakdowns. The maximum and minimum sensitivities were found to vary around 30% from the measured average sensitivity value. A thermally stimulated current analysis confirmed the results obtained in the sensitivity distribution map measurements.
Statistical machine translation from Slovenian to English

In this paper, we analyse three statistical models for the machine translation of Slovenian into English. All of them are based on the IBM Model~4, but differ in the type of linguistic knowledge they use. Model 4a uses only basic linguistic units of the text, i.e., words and sentences. In Model 4b, lemmatisation is used as a preprocessing step of the translation task. Lemmatisation also makes it possible to add a Slovenian-English dictionary as an additional knowledge source. Model 4c takes advantage of the morpho-syntactic descriptions (MSD) of words. In Model 4c, MSD codes replace the automatic word classes used in Models 4a and 4b. The models are experimentally evaluated using the IJS-ELAN parallel corpus.