Miracle-dz/UniFAR-FTUs huggingface dataset:
Chemical Modification of Interleukin-10 with Mannose 6-Phosphate Groups Yields a Liver-Selective Cytokine

Cytokines are considered a promising immunotherapy for chronic diseases, because of their potency and fundamental roles in pathological processes. However, their therapeutic use is limited because of their poor pharmacokinetics and pleiotropic effects in various organs. These problems may be overcome by cell-specific delivery of the cytokine. This approach involves chemical modification of the protein with homing devices that recognize receptors on target cells. The cytokine interleukin-10 (IL10) may be valuable as a therapeutic cytokine for patients with liver cirrhosis. However, its rapid renal elimination and general immunosuppressive activities limit therapeutic use. We therefore aim to target this cytokine in the liver, in particular to fibrogenic hepatic stellate cells (HSCs). We show that IL10 is successfully modified with mannose 6-phosphate (M6P), which is a homing device for the mannose 6-phosphate/insulin-like growth factor II (M6P/IGFII) receptor expressed on activated HSCs. Chemical modification did not diminish IL10 efficacy with regard to in vitro anti-inflammatory (lipopolysaccharide-stimulated tumor necrosis factor α release) and antifibrotic (collagen deposition and degradation) activities. Biodistribution studies with radiolabeled M6P-IL10 and IL10 in rats with liver fibrosis showed that modification with M6P groups induced a shift in the distribution from the kidneys (IL10) to the liver (M6P-IL10). Hepatocellular binding of M6P-IL10 occurred via M6P/IGFII receptors and scavenger receptors, indicating that not only HSCs but also Kupffer and endothelial cells are target cells. IL10 did not bind to these receptors. We conclude that we prepared an active and liver-specific form of the cytokine IL10 that can be evaluated for its efficacy to treat liver diseases.
Behavioral Effects of Framing on Social Media Users: How Conflict, Economic, Human Interest, and Morality Frames Drive News Sharing

We hypothesize that generic frames influence what news people share on Facebook and Twitter through three different routes: emotions, motivations, and psychological engagement. Using a mixed-methods design, a content analysis of a representative sample of articles published in six Chilean outlets was combined with in-depth interviews with digital journalists. After controlling for issue, newsworthiness, informational utility, valence, and other confounds, results show that—across platforms—a morality frame increases news sharing, whereas a conflict frame decreases it. Emphasizing economic consequences also decreases sharing, but only on Facebook. Surprisingly, the human interest angle has no noticeable effects. These results show that news frames can have behavioral consequences, and confirm the existence of a gap between preferred frames of journalists and users.
Paracrine Control of Gonadotrophs by Somatolactotrophs through TRH-induced Follistatin Production

There is increasing evidence for the existence of local regulation of hormone secretion among pituitary cells. Hormone-producing pituitary cells may communicate with each other and with folliculostellate cells. Activin is one of the regulators of follicle stimulating hormone (FSH) secretion and gene expression, whereas follistatin negatively regulates FSH production by binding to and bioneutralizing the effects of activin. In prolactin-secreting GH3 cells, hypothalamic thyrotropin-releasing hormone (TRH) has been known to stimulate prolactin synthesis and secretion. Follistatin is produced in GH3 cells and is up-regulated by TRH in an ERK dependent manner. Prolactin mRNA levels in GH3 cells are not affected by increasing the dose of exogenous follistatin, and TRH-induced prolactin expression is not modulated in the presence of follistatin. Follistatin produced in somatolactotroph GH3 cells does not affect prolactin production in these cells. In pituitary gonadotroph cell line, LT2, activin increases FSHpromoter activity and mRNA expression, and follistatin completely inhibits this activin-increased FSHgene expression. On the other hand, activin reduces the basal activity of prolactin transcription and follistatin prevents these effects. When GH3 cells and LT2 cells are co-cultured, activin-induced FSHpromoter activity is completely inhibited in the presence of follistatin. In addition, FSHmRNA is not detected in LT2 cells, when co-cultured with GH3 cells. These observations using the model for somatolactotroph and gonadotroph suggest the possibility that somatolactotrophs and gonadotrophs interact with each other, and TRH might indirectly affect gonadotropin production though follistatin.
Efficient key management based on the subset difference method for secure group communication

A new algorithm for efficient key management for secure group communication in wireless ad hoc network with mobile nodes is presented. In order to address the dynamic receiver update operations such as leave or join, the subset difference (SD) method proposed by Naor et al. is introduced. The SD method allows senders to reduce drastically the size of ciphertext to be sent to 2r-1 using a pseudo random number generator, where r is the number of revoked users (who leave the group). In the SD method, the subsets of authorized users are represented by some differences of two subsets such that i covers valid users and j excludes the revoked users in i. To have all subsets (i,j) necessary to cover all valid users in a tree, a sender has to test all possible combinations of revoked users. A naive exhaustive search for the purpose takes O(r/sup 3/) time. This is a drawback of the SD method. Hence, to address the issue for finding the cover, we propose a new efficient algorithm to reduce the cost up to O(rlog r logn) by introducing the technique for indexing nodes to be dealt with in the necessary subsets. In addition, we implement the proposed algorithm and demonstrate the performance in terms of processing time in this paper.
Server selection on the World Wide Web

Significant efforts are being made to digitize rare and valuable library materials, with the goal of providing patrons and historians digital facsimiles that capture the "look and feel" of the original materials. This is often done by digitally photographing the materials and making high resolution 2D images available. The underlying assumption is that the objects are flat. However, older materials may not be flat in practice, being warped and crinkled due to decay, neglect, accident and the passing of time. In such cases, 2D imaging is insufficient to capture the "look and feel" of the original. For these materials, 3D acquisition is necessary to create a realistic facsimile. This paper outlines a technique for capturing an accurate 3D representation of library materials which can be integrated directly into current digitization setups. This will allow digitization efforts to provide patrons with more realistic digital facsimile of library materials.
DATE 2006 Special Session: DFM/DFY Design for Manufacturability and Yield - influence of process variations in digital, analog and mixed-signal circuit design

The concepts of design for manufacturability and design for yield DFM/DFY are bringing together domains that co-existed mostly separated until now $circuit design, physical design and manufacturing process. New requirements like SoC, mixed analog/digital design and deep-submicron technologies force to a mutual integration of all levels. A major challenge coming with new deep-submicron technologies is to design and verify integrated circuits for high yield. Random and systematic defects as well as parametric process variations have a large influence on quality and yield of the designed and manufactured circuits. With further shrinking of process technology, the on-chip variation is getting worse for each technology node. For technologies larger than 180nm feature sizes, variations are mostly in a range of below 10%. Here an acceptable yield range is achieved by regular but error-prone re-shifts of the drifting process. However, shrinking technologies down to 90nm, 65nm and below cause on-chip variations of more than 50%. It is understandable that tuning the technology process alone is not enough to guarantee sufficient yield and robustness levels any more. Redesigns and, therefore, respins of the whole development and manufacturing chain lead to high costs of multiple manufacturing runs. All together the risk to miss the given market window is extremely high. Thus, it becomes inevitable to have a seamless DFM/DFY concept realized for the design phase of digital, analog, and mixed-signal circuits. New DFY methodologies are coming up for parametric yield analysis and optimization and have recently been made available for the industrial design of individual analog blocks on transistor level up to 1500 transistors. The transfer of yield analysis and yield optimization techniques to other abstraction levels - both for digital as well as for analog - is a big challenge. Yield analysis and optimization is currently applied to individual circuit blocks and not to the overall chip yielding on the one hand often too pessimistic results - best/worst case and OCV (on chip variation) factor - for the digital parts. On the other hand for analog often very high efforts are spent to design individual blocks with high robustness (>6sigma). For abstraction to higher digital levels first approaches like statistical static timing analysis (SSTA) are under development. For the analog parts a strategy to develop macro models and hierarchical simulation or behavioral simulation methodologies is required that includes low-level statistical effects caused by local and global process variation of the individual devices
Stereo Tracking and Servoing for Space Applications

This paper proposes a real-time, robust and efficient three-dimensional (3-D) model-based tracking algorithm for visual servoing. A virtual visual servoing approach is used for 3-D tracking. This method is similar to more classical nonlinear pose computation techniques. Robustness is obtained by integrating an M-estimator into the virtual visual control law via an iteratively reweighted least-squares implementation. The presented approach is also extended to the use of multiple cameras. Results show the method to be robust to occlusion, changes in illumination and mistracking.
PhiGARo: Automatic Phishing Detection and Incident Response Framework

We present a comprehensive framework for automatic phishing incident processing and work in progress concerning automatic phishing detection and reporting. Our work is based upon the automatic phishing incident processing tool PhiGARo which locates users responding to phishing attack attempts and prevents access to phishing sites from the protected network. Although PhiGARo processes the phishing incidents automatically, it depends on reports of phishing incidents from users. We propose a framework which introduces honey pots into the process in order to eliminate the reliance on user input. The honey pots are used to capture e-mails, automatically detect messages containing phishing and immediately transfer them to PhiGARo. There is a need to propagate e-mail addresses of a honey pot to attract phishers. We discuss approaches to the honey pot e-mail propagation and propose a further enhancement to using honey pots in response to phishing incidents. We propose providing phishers with false credentials, accounts and documents that will grant them access to other honey pot services. Tracing these honey tokens may lead us to the originators of the phishing attacks and help investigations into phishing incidents.
A Data Fusion Architecture for the Dynamic Follow-up of Vehicles

This article concerns road safety and driving assistance. To solve this problem, we propose a data fusion architecture based on the Dempster-Shafer theory. This multilevel approach allows the management of complementary and redundant data which come from two perception systems: an omnidirectional vision sensor and a laser telemeter. The originality of this architecture is its ability to manage and propagate uncertainties from low level data until a high level information of danger given to the driver. The first part concerns the data sensor. The second part deals with the quantification of the uncertainties of the detected vehicles, followed by a determination of situations of danger and the evaluation of their level of dangerousness with the aim of supplying the driver with an indicator of global danger around the vehicle.
Virus-Like Particle Vaccination Protects Nonhuman Primates from Lethal Aerosol Exposure with Marburgvirus (VLP Vaccination Protects Macaques against Aerosol Challenges)

Marburg virus (MARV) was the first filovirus to be identified following an outbreak of viral hemorrhagic fever disease in Marburg, Germany in 1967. Due to several factors inherent to filoviruses, they are considered a potential bioweapon that could be disseminated via an aerosol route. Previous studies demonstrated that MARV virus-like particles (VLPs) containing the glycoprotein (GP), matrix protein VP40 and nucleoprotein (NP) generated using a baculovirus/insect cell expression system could protect macaques from subcutaneous (SQ) challenge with multiple species of marburgviruses. In the current study, the protective efficacy of the MARV VLPs in conjunction with two different adjuvants: QS-21, a saponin derivative, and poly I:C against homologous aerosol challenge was assessed in cynomolgus macaques. Antibody responses against the GP antigen were equivalent in all groups receiving MARV VLPs irrespective of the adjuvant; adjuvant only-vaccinated macaques did not demonstrate appreciable antibody responses. All macaques were subsequently challenged with lethal doses of MARV via aerosol or SQ as a positive control. All MARV VLP-vaccinated macaques survived either aerosol or SQ challenge while animals administered adjuvant only exhibited clinical signs and lesions consistent with MARV disease and were euthanized after meeting the predetermined criteria. Therefore, MARV VLPs induce IgG antibodies recognizing MARV GP and VP40 and protect cynomolgus macaques from an otherwise lethal aerosol exposure with MARV.
The Well-Founded Semantics Coincides with the Three-Valued Stable Semantics

We introduce 3-valued stable models which are a natural generalization of standard (2-valued) stable models. We show that every logic program P has at least one 3-valued stable model and that the well-founded model of any program P VGRS90] coincides with the smallest 3-valued stable model of P. We conclude that the well-founded semantics of an arbitrary logic program coincides with the 3-valued stable model semantics. The 3-valued stable semantics is closely related to non-monotonic formalisms in AI. Namely, every program P can be translated into a suitable autoepistemic (resp. default) theory ^ P so that the 3-valued stable semantics of P coincides with the (3-valued) autoepistemic (resp. default) semantics of ^ P. Similar results hold for circumscrip-tion and CWA. Moreover, it can be shown that the 3-valued stable semantics has a natural extension to the class of all disjunctive logic programs and deductive databases. 1 Finally, following upon the recent approach developed by Gelfond and Lifschitz, we extend all of our results to more general logic programs which, in addition to the use of negation as failure, permit the use of classical negation.
The Force of Dispositifs *

The social sciences have much to gain by paying particular attention to the place that dispositifs occupy in social life. The utility of such a perspective is clear from an examination of the research that has made use of this notion since the end of the 1970s. Yet in addition to the wide variety of definitions and objectives relating to the concept of dispositif, a reading of these works also reveals some of the difficulties that have been encountered along the way. An effort to clarify and renew the discussion on both the conceptual and methodological levels is thus worthwhile, and this article is a contribution to that end. The first section sets out the results of our conceptual inquiry into the notion of dispositif. The second puts forward a series of propositions designed to develop a “processual” approach to dispositifs. Finally, we return to several studies that we have conducted from this perspective relating to the dispositifs of redress, looking at the doctrinal work of jurists around a criminal trial, the practices of lawyers in the courtroom, the reactions of victims of a medical scandal to a compensation fund, and the historical transformation of dispositifs of redress for medical accidents since the beginning of the nineteenth century. This enables us to clarify the approach we propose and to suggest new avenues for the future.
Anonymous folksonomies for small enterprise webs: a case study

Tags and emergent folksonomies are a potentially rich new source of document annotations, offering query independent and dependent evidence for exploitation by information retrieval systems. Previous research has shown that tags may facilitate improved web search in an environment where each tagging action generates a (user, tag, resource) triple. For websites operated by a public institution, operational or privacy concerns may prevent the recording of data capable of identifying individuals. This leads to a simpler anonymous tagging system but is likely to reduce user motivation for tagging, since the user cannot access their own set of tags. It also means that votes for tags are not counted, and a potentially useful joining attribute is not available. Using webpage, metadata, query, click, anchortext and tag data provided by a public museum, we demonstrate that, despite these limitations, tag data collected by an anonymous tagging system has the potential to improve retrieval effectiveness.
Gravitational Lensing in a Concordance ΛCDM Universe: The Importance of Secondary Matter along the Line of Sight

To date, in almost all strong gravitational lensing analyses for modeling giant arc systems and multiple quasar images, it has been assumed that all the deflecting matter is concentrated in one lens plane at a certain distance—the thin lens approximation. However, in a few observed cases, lenses at more than one redshift have been identified as contributing to the image splitting. Here we report on a quantitative investigation of the importance and frequency of significant multiple lensing agents. We use multilens plane simulations to evaluate how frequently the combination of two or more lens planes is essential for multiple imaging, as compared with the cases for which a single lens plane alone provides enough focusing to be supercritical. We find that the fraction of cases for which more than one lens plane contributes significantly to a multiimage lensing situation is a strong function of source redshift. For sources at redshift unity, 95% of lenses involve only a single mass concentration, but for a more typical scenario with, e.g., a source at a redshift of zs = 3.8, as many as 38% of the strongly lensed quasars/arcs occur because of a significant matter contribution from one or more additional lens planes. In the roughly 30% of cases when additional planes make a significant contribution, the surface mass density of the primary lens will be overestimated by about 10%-15%, if the additional contributions are not recognized.
Opportunistic spectrum scheduling for multiuser cognitive radio: a queueing analysis

We develop a queueing analytic framework to study the data link layer quality-of-service performance measures for cognitive radio users in an infrastructure-based dynamic spectrum access environment. In order to allocate the available spectrum white spaces among the cognitive radio users in a spectrum overlay scenario, an opportunistic scheduling scheme is considered. The queueing model considers bursty traffic arrival pattern at the cognitive radio user ends, finite buffer size, activity of primary users (i.e., dynamic channel availability), and correlated channel fading. We present a step-by-step procedure to derive the delay distribution, average throughput, and packet loss rate for the cognitive radio users. The proposed framework facilitates cross-layer design for improved QoS experience in cognitive radio networks. Usefulness of the developed analytical model is demonstrated through example applications.
FPGA TECHNOLOGY IN INSTRUMENTATION AND RELATED TOOLS

Field Programmable Gate Arrays (FPGA) have become an alternative to traditional Digital Signal Processors (DSP) in many applications. In some cases, where high throughput is the main concern, an FPGA-based system may in fact be the only solution to fulfil the requirements. In the area of particle accelerators, FPGAs are used in many contexts, ranging from digital feedback loops for power converters and RF cavities to Digital Signal Processing for beam instrumentation. These designs harness the vast amount of logic resources inside FPGA chips to deliver unprecedented performance through parallelism and pipelining. After an introduction to the internal architecture of FPGAs and the design process, including advanced issues such as floorplanning, we look at two important techniques to implement arithmetic in FPGAs: Distributed Arithmetic (DA) and the COordinate Rotation DIgital Computer (CORDIC) algorithm. The goal is not to exhaust the list of Digital Signal Processing techniques for FPGAs, but rather to illustrate ways in which FPGAs are used to maximize performance.
Session Title

results: Prevalence of pre-transplant depression among heart transplant recipients increased from 5.7% in 2003 to 9.3% in 2010 (Trend P, <0.001). In-hospital mortality occurred in 2.5% and 5.5% of heart transplant recipients with and without depression, respectively (Adj. odds ratio {OR}, 0.60; 95% confidence interval {CI}, 0.41-0.88; P<0.001). Pre-transplant depression was not associated with a prolonged hospital stay and total hospital charge (Table).
Is hypertension more strongly linked to age-related cognitive decline in executive function than in elementary speed function?: Effects of research methods on the findings@@@横断的データと縦断的データによる検討

Takeshi Hatta (Department of Health Science, Kansai University of Welfare Sciences, hatta@tamateyama.ac.jp) Akihiko Iwahara (Department of Education (Psychology Course), Kyoto Women’s University, iwahara@kyoto-wu.ac.jp) Kimiko Kato (Faculty of Psychology, Aichi Syukutoku University, kimi@asu.aasa.ac.jp) Chie Hotta (Department of Education, Kansai University of Welfare Sciences, chie_hotta@yahoo.co.jp) Taketoshi Hatta (Department of Health Science, Gifu University of Medical Sciences, hatta@u-gifu-ms.ac.jp) Junko Hatta (Faculty of Psychological Science and Physical Science, Aichi Gakuin University, hatta105@dpc.agu.ac.jp) Kazumi Fujiwara (Faculty of Nursing, Suzuka University of Medical Science, f-kazumi@suzuka-u.ac.jp) Emi Ito (Department of Occupational Therapy, School of Health, Nagoya University, emiito@met.nagoya-u.ac.jp) Nobuyuki Hamajima (Graduate School of Medicine, Nagoya University, nhamajima@med.nagoya-u.ac.jp)
From Light to Spikes: a Large-Scale Retina Simulator

The purpose of this article is to provide potential neuroscientists and computer scientists with an artificial retina model, delivering spikes to higher-level visual tasks simulations. The architecture of our retina model is based on recent physiological studies, so that each feature is related to real retina characteristics. The model includes a linear filtering process, followed by a static non-linearity, and then a spike generation process. Two series of tests were performed: firstly on single cells for which ground truth is available, secondly on realistic visual scenes. This retina model can be further extended and we describe some possible additional features. It is our conviction that building such a bio-inspired model will help in better understanding how the retina performs and also in relating observations to biological mechanisms.