Miracle-dz/UniFAR-FTUs huggingface dataset:
Six‐Month Daily Administration of Parathyroid Hormone and Parathyroid Hormone—Related Protein Peptides to Adult Ovariectomized Rats Markedly Enhances Bone Mass and Biomechanical Properties: A Comparison of Human Parathyroid Hormone 1–34, Parathyroid Hormone‐Related Protein 1–36, and SDZ‐Parathyroid 

Daily administration of parathyroid hormone (PTH) and PTH‐related protein (PTHrP) peptides has been shown to increase bone mass and strength in animals and, for PTH, to increase bone mass in humans. Long‐term direct comparison of multiple members of the PTH/PTHrP family in vivo has not been reported. We therefore selected three PTH/PTHrP molecules for direct comparison in vivo in an adult rat model of postmenopausal osteoporosis: PTH(1‐34), PTHrP(1‐36), and the PTH analog, SDZ‐PTH 893 {Leu8, Asp10, Lys11, Ala16, Gln18, Thr33, Ala34 human PTH 1–34 [hPTH(1‐34)]}. A 6‐month study was performed in which adult (6‐month‐old) vehicle‐treated ovariectomized (OVX) and sham OVX rats were compared with OVX rats receiving 40 μg/kg per day of either PTH(1‐34), PTHrP(1‐36), or PTH‐SDZ‐893. Bone mass, as assessed by ash weight and densitometry, bone histomorphometry, biomechanical properties at trabecular and cortical sites, and indices of bone formation markedly increased in all three PTH/PTHrP peptide‐treated groups as compared with controls. In general, this improvement followed a rank order of SDZ‐PTH‐893 > PTH > PTHrP. The adverse effect profile also was greatest with SDZ‐PTH‐893; these rats developed moderate hypercalcemia, marked renal calcium accumulation, and displayed a 13% mortality. These studies show that PTH(1‐34), PTHrP(1‐36), and PTH‐SDZ‐893 significantly and progressively increase bone mass and bone strength in this rat model of postmenopausal osteoporosis. The adverse effect profile correlates in general terms with efficacy. All three peptides show promise as skeletal anabolic agents. Further studies in humans will be required to define optimal efficacy‐to‐adverse effect ratios and relative efficacy for each peptide in human osteoporosis.
Evaluation of emergency department nursing services and patient satisfaction of services.

AIMS AND OBJECTIVES To identify nursing services and assess patient satisfaction in patients who present to the emergency department. BACKGROUND Emergency nursing care is a significant determinant of patient satisfaction. Patient satisfaction is often regarded as a reliable indicator of the quality of services provided in the emergency department. DESIGN This is a descriptive study. METHODS Eighty-four patients who presented to the university emergency department were included in the study. The study data were collected by the Patient Information Form and the Satisfaction Level Form. RESULTS Emergency nursing services, including history taking, assessing vital signs, preparing the patient for an emergency intervention, oxygen therapy, drug delivery and blood-serum infusion were shown to be more commonly provided compared with other services such as counselling the patients and the relatives about their care or delivering educational and psychosocial services. However, 78·6% of the patients were satisfied with their nursing services. The highest satisfaction rates were observed in the following sub-dimensions of the Satisfaction Level Form: availability of the nurse (82·1%), behaviour of the nurse towards the patient (78·6%) and the frequency of nursing rounds (77·4%). CONCLUSIONS The most common practices performed by nurses in the emergency department were physical nursing services. Patient satisfaction was mostly associated with the availability of nurses when they were needed. Our results suggest that in addition to the physical care, patients should also receive education and psychosocial care in the emergency department. RELEVANCE TO CLINICAL PRACTICE We believe that this study will contribute to the awareness and understanding of principles and concepts of emergency nursing, extend the limits of nursing knowledge and abilities, and improve and maintain the quality of clinical nursing education and practice to train specialist nurses with high levels of understanding in ethical, intellectual, administrative, investigative and professional issues.
Effect of moisture on tensile strength of bulk solids. I. Sodium chloride and effect of particle size.

The effect of moisture on the tensile strength of packed beds of a variety of particle-size fractions of sodium chloride is reported. At a constant state of packing, the tensile strength of the coarse noncohesive fractions is shown to increase to a plateau as the moisture content rises. This is attributed to an increase in the number and dimension of liquid pendular bonds. For the finer, cohesive fractions, the effect of moisture is initially to cause an increase in tensile strength due possibly to a reduction in interparticle separation as well as pendular bridging. Above a critical moisture content, the tensile strength decreases due to a disruption of the inherent forces of cohesion and the failure to produce new pendular bonds at points of near contact.
INTRACELLULAR MUCOPOLYSACCHARIDES IN THE NORMAL HUMAN BRONCHIAL TREE.

Mucus-secreting cells in the human bronchial tree have been studied by histochemical methods, using Alcian blue and periodic acid-Schiff and also aldehyde Fuchsin (AF) and Alcian blue (AB), in the order of AF/AB and AB/AF and in association with treatment by cetyl-triethyl-ammonium-bromide and methylation-saponification. By a combination of stains, the acid mucopolysaccharides have been distinguished from the neutral: neuraminic acid has been located by using consecutive sections stained as above, one of which had previously been treated with neuraminidase. Certain deductions about the nature of Alcian blue staining are made. Neutral mucopolysaccharide is mainly confined to the granular cells, acid mucopolysaccharide to distended cells. Some of the latter contain neuraminidase-susceptible acid mucopolysaccharide, while in others it is only partially susceptible; the remaining acid mucopolysaccharide is likely to be neuraminidase-resistant neuraminic acid. Surface epithelium, ducts and glands each have a characteristic distribution of the various cell types. The findings suggest a cycle of secretion.
Risks and Potentials in Beijing’s Real Estate Market

This paper analyses the ups and downs in the real estate market in Beijing, the capital city of China. As China opens its financial market to foreign investors in addition to imports and exports of goods and services, the health in China’s real estate market will also have a significant impact on its trading partners. This is especially true as more and more Chinese investors are considering US market for investment as well as permanent settlement. However, there has not been a lot of study in this area due to lack of reliable data and the strict government regulations in China’s real estate market. This paper will outline some risks and potentials in Beijing’s Real Estate Market and shed some light on whether China has had or will have a real estate bubble. The research findings tend to suggest these bubbles can hardly collapse in a short run due to strongly protective policies and government financial support. In 2010, during Warren Buffett’s business visit to China, He commented that it is not only a gamble in the Beijing (China’s capital) real estate market, but a huge gamble; many people are gambling big in this market. Seven years later, the Beijing real estate market is still showing a very strong growth. In Chinese, the word, “Crisis”, is combined of twoword roots “Risk” and “Opportunity”. Hence, this paper will analyze the risks and opportunities in Beijing’s real estate market and how government policies have influenced the real estate prices.
ML estimation of seafloor topography using multi-frequency synthetic aperture sonar

In this paper we investigate synthetic aperture sonar (SAS) broadband interferometric height estimation using multiple frequency bands. The height estimate is generated using a maximum likelihood (ML) estimate combining the data from the hydrophones. To decrease the effect of the large variance of the phase difference estimates the broadband signal is divided into smaller subbands and combined to give a height estimate with much improved accuracy, albeit at a reduced resolution due to the reduction in system bandwidth. Results are shown for a two element sonar, and the improvement obtained using multiple frequency bands subbanded to give a lower variance in the height estimate. Multiple pings are also combined as multiple looks, further reducing the height variance.
The application of Scalable Agile in Dutch government

This research looks into the possibility of implementing Scalable Agile Framework (SAFe) within Dutch government IT projects. The Large Solution configuration of SAFe is used for analysis. Besides literature research, IT professionals with experience within Dutch government IT projects have been interviewed. Required cultural changes within Dutch government have been identified and an analysis was made of different types of projects within the Dutch government. Not all Dutch government IT projects will be able to fully implement SAFe, but some features can still be implemented. Dutch government would benefit from implementing SAFe, or Agile in general.
CHALLENGES MEDICAL SOCIAL WORKERS FACE THAT LEAD TO BURNOUT

iii ACKNOWLEDGEMENTS . iv TABLE OF CONTENTS . v CHAPTER ONE: INTRODUCTION Problem Formulation. 1 Purpose of the Study . 3 Significance of the Project for Social Work . 4 CHAPTER TWO: LITERATURE REVIEW Introduction . 6 Challenges Health Care Providers Encounter in Practice . 6 Long Work Hours . 7 High Workload. 7 Challenges that Social Workers Encounter in Practice . 8 Insufficient Time . 8 Large Number of Cases . 8 Challenging Clients . 9 Responsibilities of Medical Social Workers and its Uniqueness from Other Social Work Fields . 9 Gaps in Literature . 10 Theories Guiding Conceptualization . 11 Summary . 12 CHAPTER THREE: METHODS Introduction . 13
Pulsed electromagnetic fields versus laser therapy on enhancing recovery of diabetic foot ulcer: A single blind randomized controlled trial

Background: The nature of chronic diabetic foot ulceration disables the normal stages of healing, inducing a state of pathological inflammation resulting in a delayed healing process which predisposes the patients to infections. Purpose: This study was performed to compare between laser therapy and pulsed electromagnetic field (PEMF) therapy in management of infected diabetic foot ulcers. Design: A prospective, randomized, single-blind, pre–post-test, controlled trial. Setting: Participants were referred from the Outpatient Clinic Kasr El-Ani hospital to be treated in the Outpatient Clinic, Faculty of physical Therapy, Cairo University. The study was conducted between June 2015 and August 2016. Participants: Thirty participants with diabetic foot ulcers, their age ranged from 45-60 years. Interventions: The first group (GA) received 0.5 Gauss PEMF and the second group (GB) received 10 J/cm2 Infra-red laser therapy. Main Outcome Measure: the primary outcome was wound surface area while the secondary outcome was colony count that were measured before the experiment and after 12 sessions of treatment. Results: Thirty participants with DFU (group A n=15; group B n=15) were randomized and analyzed. Comparing both groups post-program revealed that there was significant reduction in wound surface area in favor of (GB). However, no significant difference was found in colony count. Conclusion: 10 J/cm2 infra-red laser and 0.5 Gauss. PEMF are two effective and recommended modalities in management of infected diabetic foot ulcer. However, laser therapy is better for wound regeneration regarding the same used parameters of treatment.
DIESEL‐MP2: A new program to perform large‐scale multireference‐MP2 computations

This article presents a new MR‐MP2 code (Multi‐Reference Møller–Plesset 2nd order) suitable for the computation MR‐MP2 energies of extended systems with strong near degeneracy effects (e.g., open shell systems). It is based on the DIESEL program package developed by Hanrath and Engels. Due to improved algorithms the new code is able to handle systems with 400–500 basis functions and more than 100 electrons. The code is made for parallel computers with distributed memory, but can also be run on local machines. It possesses two integral interfaces (MOLCAS, TURBOMOLE). The algorithms are briefly introduced and timings for the Neocarzinostatin chromophore are presented. The efficiencies of the codes obtained with Intel or GNU compilers are compared. © 2006 Wiley Periodicals, Inc. J Comput Chem 27: 1055–1062, 2006
Relationship Between Bone Quantitative Ultrasound and Fractures: A Meta‐Analysis

The relationship between bone QUS and fracture risk was estimated in a systematic review of data from 14 prospective studies of 47,300 individuals and 2350 incident fractures. In older women, low QUS values were associated with overall fracture risk, low‐trauma fractures, and with hip, forearm, and humerus fractures separately.
Intégration des systèmes à absorption solaire de petites puissances aux bâtiments - approche multifonction solaire : chauffage, ECS et rafraîchissement

L’introduction des nouvelles machines frigorifiques a absorption des petites puissances ouvre des nouvelles perspectives pour les systemes solaires multifonction multi-source (SYSMFS) qui exploitent le potentiel de l’energie solaire pour le chauffage, le refroidissement et la preparation de l’eau chaude sanitaire (ECS). Les systemes solaires combines (SSC), qui ont precedes les SYSMFS, manquaient neanmoins une procedure adaptee pour le dimensionnement de leurs composants principaux : le panneau solaire et le ballon solaire de stockage thermique. De point de vue de l’energie et du cout d’investissement et d’exploitation, une methode de dimensionnement basee sur le pic de charge ne conviendrait pas si la source d’energie n’est pas garantie d’etre stable dans le temps. Une optimisation des composants principaux par la simulation peut etre alors une solution clef pour le dimensionnement optimal de SYSMFS. A partir des informations sur les SSC trouvees dans la litterature et celles de fabricant de la machine frigorifique, un schema hydraulique initial a ete elabore pour un SYSMFS. La modelisation de ce schema est complexe car des simulations et des modifications repetitives ont ete necessaires pour eliminer les problemes potentiels de convergence de la solution. A partir de cette experience, une methodologie de conception assistee par simulation a ete elaboree afin d’en profiter pour des modelisations similaires. En tant que telle, le modele devrait etre pret pour la phase l’optimisation. Une etude parametrique a ete menee sur le modele SYSMFS ; elle offre les donnes requises pour la comparaison des algorithmes d’optimisation qui sont testes par la suite. Le resultat de cette etude est une surface de reponse qui represente le cout du SYSMFS en fonction de la superficie du panneau solaire et du volume de stockage thermique du ballon solaire. Pour reduire le nombre des simulations requis par une etude parametrique complete, l’utilisation d’un algorithme d’optimisation est necessaire. Un algorithme base sur le plan d’experience (OptDOE) a ete developpe et sa performance est comparee avec celles d’un algorithme d’optimisation hybride sur une fonction de reference de Rosenbrock et sur le modele SYSMFS. Compare a l’algorithme hybride, OptDOE a montre une bonne performance. Le nombre de simulations est reduit et les valeurs optimales trouvees, par cette methode, sont porches de celles de l’etude parametrique L’OptDOE permet egalement de decrire le comportement du modele SYSMFS au voisinage de l’optimum avec une fonction cout approximee. Cette information est importante surtout au cas ou la fonction cout a la forme d’une vallee. Dans ce cas, des valeurs differentes de l’optimum donnent presque le meme cout global.
The Role of Dietary n–6 and n–3 Fatty Acids in the Developing Brain

The dietary requirements for essential fatty acids and the possibility of a specific role for the polyunsaturated fatty acid docosahexaenoic acid (DHA) is one of the most controversial areas in infant nutrition. DHA is found in unusually high concentrations in the brain and is selectively accumulated during fetal and infant brain growth. DHA can be synthesised through a complex series of chain elongation-desaturation reactions from α-linolenic acid, but the efficiency of this process in young infants is not clear. Clinical studies on the potential benefits to neural development of dietary DHA have yielded conflicting results. Recent studies have provided evidence that plasma DHA is available to developing brain and that DHA is involved in dopamine and serotonin metabolism. These findings should guide clinical studies to more sensitive measures of the functional roles of dietary n–3 fatty acids and to clinical conditions where n–3 fatty acids may have benefit.
Optimization of Dynamic Vehicle Routing Problem for Fresh Agricultural Products

The perishability of fresh agricultural products and real-time traffic information greatly reduce the customers’ satisfaction with fresh products distribution. In this paper, the vehicle distribution model for fresh agricultural products was established to maximize customers’ satisfaction with delivery time and freshness based on real-time traffic information. Genetic algorithm was adapted to get initial routes and dynamic adjusted routes. The results show that customers’ satisfaction can be improved and effect of dynamic traffic can be weakened by rational initial routing optimization and dynamic adjustment.
Data science in Sweden Exploring the state of data science use in Swedish businesses

Data science brings with it vast opportunities. New technology enables advanced analytics to an increased extent and organizations seek to extract business value by becoming increasingly data driven. On behalf of the Technology Management and Economics department at Chalmers University of Technology this thesis seeks to explore the current adoption of data science and its implications among Swedish businesses. The focus of the study lies on mapping the current state, aiming to understand what the future holds and which challenges rms will have to deal with in the process of adopting data science into their organizations. Drawing upon data from interviews with representatives from a diverse set of Swedish rms, along with current research in the eld of data science, opportunities and challenges within the three areas competence, organization, and business impact are identi ed. With regard to business impact, there is a substantial gap between potential and actual value extracted from data science among Swedish businesses. And while it is clear that Swedish rms seek to develop their capabilities within the eld, the gap between potential and real value extracted is deemed to grow unless considerable action is taken within two areas: (1) develop the right managerial competence to bridge between technology and management, and (2) address the organizational challenges related to integrating data science to the operations of the rm. Drawing upon literature on data science and change management, the study provides clarity in what competencies should be focused on in order to foster 'data translators', and it also conceptualizes a seven step organization process which should be leveraged as a source of orientation for rms under the process of transition from 'no data science operations' to 'full-scale data science operations'.
Suppression of microRNAs by dual-targeting and clustered Tough Decoy inhibitors

MicroRNAs (miRNAs) are ubiquitous regulators of gene expression that contribute to almost any cellular process. Methods for managing of miRNA activity are attracting increasing attention in relation to diverse experimental and therapeutic applications. DNA-encoded miRNA inhibitors expressed from plasmid or virus-based vectors provide persistent miRNA suppression and options of tissue-directed micromanaging. In this report, we explore the potential of exploiting short, hairpin-shaped RNAs for simultaneous suppression of two or more miRNAs. Based on the “Tough Decoy” (TuD) design, we create dual-targeting hairpins carrying two miRNA recognition sites and demonstrate potent co-suppression of different pairs of unrelated miRNAs by a single DNA-encoded inhibitor RNA. In addition, enhanced miRNA suppression is achieved by expression of RNA polymerase II-transcribed inhibitors carrying clustered TuD hairpins with up to a total of eight miRNA recognition sites. Notably, by expressing clustered TuD inhibitors harboring a single recognition site for each of a total of six miRNAs, we document robust parallel suppression of multiple miRNAs by inhibitor RNA molecules encoded by a single expression cassette. These findings unveil a new potential of TuD-based miRNA inhibitors and pave the way for standardizing synchronized suppression of families or clusters of miRNAs.
MRFP: Discovery Frequent Patterns Using MapReduce Frequent Pattern Growth

In this paper, a novelty of a new method has been presented. MRFP-Growth is implementing to solve the problem of discovering frequent patterns with massive datasets. Most of the frequent patterns algorithms are unable to manipulate with the large datasets, our scheme implement FP-Growth method under MapReduce framework in Hadoop platform to decrease the massive datasets. The efficiency and performance of a new method has been increased compare with other mining algorithms.
A comparison between epidural Butorphanol and Tramadol for postoperative analgesia, sedation and side effects using CSEA technique for surgeries below the level of umbilicus

Background and Aims: Epidural analgesia using low doses of local anesthetic agent with or without adjuvants like opioids is a popular, simple, effective and economical way of providing postoperative analgesia. We proposed to evaluate and compare the efficacy of epidural opioids, Butorphanol and Tramadol using Combined Spinal Epidural Analgesia (CSEA) technique for surgeries below the level of umbilicus for postoperative analgesia, sedation and side effects.Methods: In this prospective, double blind, randomized controlled clinical trial, 60 patients aged 18 to 60 years, ASA grade 1 or 2 posted for planned elective surgery below the level of umbilicus were selected.Study Design: The patients were randomly allocated into 2 groups to receive postoperatively either 1 mg of inj. Butorphanol (dissolved in 10 ml of normal saline) (Group B) or 50 mg of inj. Tramadol (dissolved in 10 ml of normal saline) (Group T) epidurally as a bolus dose when the VAS score for pain was more than 4 after the conclusion of surgical procedure as the effect of spinal anaesthesia started wearing off.Statistics and Results: The mean duration of analgesia with tramadol (group T) 6.481 ( 0.86842) hrs. was significantly higher than with butorphanol (group B) i.e., 5.352 (0.33258) hrs with a p value of 0.0001. Pain scores were also significantly lower statistically in group B as compared to group T. Sedation scores were significantly higher in group B than group T, which was statistically highly significant (p= 0.0001). Conclusion: Both epidural, butorphanol and tramadol provided good postoperative analgesia. The duration of analgesia was longer with tramadol, quality of analgesia was better with butorphanol, sedation more with butorphanol as compared to tramadol and other side effects were comparable.