Miracle-dz/UniFAR-FTUs huggingface dataset:
Educational Contributions Of The Nurse In The Prevention Of Sepsis In The Unit Of Intensive Therapy: Integrative Review

Sepsis is defined as a syndrome of inflammatory response, motivated by an aggressive agent, associated with systemic infection, the early approach of the infectious agent, both in the direction of diagnosis and in the control of infectious focus, are fundamental for the good evolution of the patient. This pathology has been considered a global health problem, affecting a large number of people and causing high rates of morbidity and mortality. OBJECTIVE: The study aimed to investigate how nurses contribute in an educational way in the prevention of complications caused by sepsis in an intensive care unit. METHOD: The research was carried out through an electronic search of scientific papers published in the databases LILACS, SCIELO and PUBMED, portal of the virtual library in health. Other materials were located in scientific journals available on university websites and articles related to the subject. The initial evaluation of the material occurred through the reading of the abstracts, in order to select those that met the objectives of the study, with this, 37 articles were selected. In carrying out the research it was possible to verify that the recognition of sepsis by nursing professionals is mainly identified through the changes in the signs and symptoms that are observed through the provision of care to these critical patients. RESULTS: It has been shown that even with all the advances in the production of knowledge about the pathophysiology and the treatment of sepsis, it is still possible to find several difficulties for the proper handling in the diagnosis and in the ideal treatment for each particular case. CONCLUSION: The professional nurse should always be updating and seeking new knowledge for a fast, safe and effective action, in conjunction with the entire health team to promote quality and resolutive care for the patient, especially those affected by sepsis.
Genome-wide prediction of highly specific guide RNA spacers for CRISPR-Cas9-mediated genome editing in model plants and major crops.

Dear Editor, RNA-guided genome editing (RGE) using the Streptococcus pyogenes CRISPR-Cas9 system (Jinek et al.,2012;Cong et al.,2013;Mali et al.,2013b) is emerging as a simple and highly efficient tool for genome editing in many organisms.The Cas9 nuclease can be programmed by dual or single guide RNA (gRNA) to cut target DNA at specific sites,thereby introducing precise mutations by error-prone non-homologousend-joining repairing or by incorporating foreign DNAs via homologous recombination between target site and donor DNA.The gRNA-Cas9 complex recognizes targets based on the complementarity between one strand of targeted DNA (referred as protospacer) and the 5'-end leading sequence of gRNA (referred to as gRNA spacer) that is approximately 20 base pairs (bp) long (Figure 1A). Besides gRNA-DNA pairing,a protospacer-adjacent motif (PAM) following the paired region in the DNA is also required for Cas9 cleavage.Recent studies reveal that Cas9 could cut the PAM-containing DNA sites that imperfectly match gRNA spacer sequences,resulting in genome editing at undesired positions.
On Speech Problems with Fixed Restorations on Implants in the Edentulous Maxilla: Introduction of a Novel Management Concept.

BACKGROUND Little attention has been paid to the effect of implant restorations on speech. PURPOSE The aim of this study was threefold: (1) to find out if speech problems occur after inserting a fixed provisional restoration in the edentulous maxilla; (2) to explore speech adaptation in case articulation problems arise after rehabilitation; and (3) to describe the effect of changing the shape of the restoration on improving speech. MATERIALS AND METHODS Ten patients with an edentulous maxilla were treated with fixed rehabilitation on implants. Speech evaluation was performed at four occasions: before implant surgery, immediately after restoration, and 3 weeks later before and after managing the speech problem by changing the shape of the restoration if speech problems occurred. Comparative three-dimensional-analysis of casts of the restoration before and after changing the shape of the restoration was carried out. RESULTS The majority of patients (n = 7) experienced speech problems immediately after rehabilitation. Three weeks later, none of the seven patients with deteriorated speech returned to baseline speech. Then, volumetric reduction of the palatal aspects of the (pre)molars was performed, which allowed speech to return to baseline levels in five out of seven patients. In the two remaining patients, the intervention resulted in an improvement of speech without reaching their baseline levels. Three-dimensional-analysis showed that reducing the palatal volume of the premolars was effective in correcting speech. CONCLUSIONS Speech problems may frequently occur after fixed rehabilitation of the completely edentulous maxilla. A novel speech management concept, consisting of reducing the palatal volume of the (pre)molars, is introduced, demonstrating to solve speech problems in most cases.
Optical pressure sensing for tangible user interfaces

In this paper we present a low cost pressure sensing method for Tangible User Interface (TUI) objects on interactive surfaces, using conventional FTIR and DI tracking. While current TUIs use optical tracking for an object's position and orientation, they rely on mechanical or electric enhancements to enable sensing of other input parameters such as pressure. Our approach uses dedicated marker pads for pressure sensing embedded into an optical marker pattern for position and orientation tracking. Two different marker designs allow different precision levels: Number of Contacts (NoC) allows click sensing and Area of Contact (AoC) enables continuous pressure sensing. We describe the working principles of the marker patterns and the construction of the corresponding tangible objects. We have tested continuous pressure sensing in a preliminary user study and will also discuss limitations of our approach.
Finite-state computational morphology - treatment of the Zulu noun

Morphological analysis is a basic enabling application for further kinds of natural language processing, including part-of-speech tagging, parsing, translation and other high-level applications. Automated morphological analyzers exist for many of the European languages, but have not been reported for any of the indigenous languages of southern Africa. Our project in computational morphological analysis/generation includes the production of an automated morphological analyzer/generator for Zulu, using finite-state methods and tools. In this paper we elaborate on the use of finite-state methods in computational morphology, and report on our treatment of the Zulu noun.
Evaluation of GPR50, hMel-1B, and ROR-&agr; Melatonin-related Receptors and the Etiology of Adolescent Idiopathic Scoliosis

Background Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity in children. Studies have shown low melatonin levels resulting from pinealectomy in chickens and mice result in the development scoliosis, whereas supplementation with melatonin after the pinealectomy prevented it. The mere characterization of low melatonin levels is not sufficient to explain the development of idiopathic scoliosis in primates and humans, but we hypothesize that a mutation in melatonin-related receptors may be involved with the development of scoliosis. Methods The coding, splice-site, and promoter regions of 3 melatonin-related receptors (hMel-1B, ROR&agr;, and GPR50) were evaluated by DNA sequencing for variants associated with the phenotype of adolescent idiopathic scoliosis. An initial screening of 50 scoliosis patients with adolescent idiopathic scoliosis was compared with 50 controls by DNA sequencing of the 3 receptors. Additional cases and controls were evaluated when genetic variants were observed (for a total of 885 individuals). Results No significant differences were found in the hMel-1B and ROR&agr; receptors. We found 2 cSNPs in GPR50 (rs561077 and rs13440581) in the initial 50 patients. To evaluate the significance of these cSNPs, an additional 356 patients and 429 controls were analyzed. When the combined groups were analyzed, no significant associations were observed. Conclusions Despite the observed relationship between melatonin and scoliosis, there is no significant association between mutations found in any known melatonin-related receptors with adolescent idiopathic scoliosis. The strong evidence of a melatonin-related cause for the development of idiopathic scoliosis still encourages research into undiscovered melatonin-related receptors, melatonin-related hormones, and the catalytic enzymes for the serotonin-melatonin pathway. Clinical Relevance This investigation is a genetic testing of the remaining currently known melatonin-related receptors that have not been analyzed earlier for association with AIS. Given the support in the literature of a relationship between melatonin and AIS, we have shown no mutations in any of the known melatonin-related receptor in patients with AIS.
Tuning the band-stop filter effect in mobile phone antennas

A slot placed between the feed and the ground connections of a single shorted microstrip antenna (PIFA) in a two antenna system can produce a band-stop filter effect in one of the frequency bands where both antennas radiate at the same frequency, but have very high isolation. The slot forms a band-stop filter, creating a large group delay at certain frequencies at a particular anti-resonance frequency. This paper analyzes methods to tune the band-stop filter effect by adjusting the slot width and additional ground connections. The antenna geometry analyzed is similar to a two antenna system inside a mobile device where the first antenna with slots has both lower band and high band resonances (quad-band GSM or dual-band LTE) and the second antenna is a wide-band single frequency antenna at LTE/3G/WiMAX.
Functional implications of oligomerization of simian virus 40 large T antigen during lytic virus infection

The formation of oligomers of simian virus 40 (SV40) large T antigen in SV40-infected and -transformed monkey cells was analyzed by sucrose density gradient centrifugation. The overall distribution of total T antigen during lytic infection showed mainly low-molecular-weight forms (monomers and dimers) in the early phase (10 h postinfection) and an increase in the number of oligomers in the late phase of the lytic cycle (36 h postinfection), indicating an accumulation of these final products. In contrast, studying the conversion of newly synthesized T antigen into oligomers by appropriate pulse-chase radiolabeling of infected cells revealed that this processing decelerates considerably during the late phase of infection. This mechanism can be reaccelerated by blocking DNA replication with aphidicolin. Since none of these results could be obtained by using synchronized SV40-transformed monkey cells (COS-1), these observations are compatible with the idea that the process of T antigen oligomerization may be involved in viral, but not in cellular, DNA synthesis.
Influence of short photoperiods on reproductive organs and estrous cycles of normal and pinealectomized female Djungarian hamsters, Phodopus sungorus.

This study was designed to analyze morphological changes in the reproductive organs and endocrine changes in the serum and pituitaries of female Djungarian hamsters during regression, the period of involution and early spontaneous recrudescence in response to short photoperiods. In addition, the involvement of the pineal gland on the inhibitory response to short photoperiods was investigated. In the first study, 63 adult female hamsters were divided into five groups, which were either pinealectomized at the time of transfer or 11 wk after transfer into short photoperiods, or exposed to different light regimens. The estrous cycles of these hamsters were recorded by vaginal smears for a period of 34 wk. In a second study, 156 adult female hamsters were divided into 14 groups and maintained under the influence of long or short photoperiods for 0-33 wk. The animals were killed by decapitation at 3-wk intervals and analyzed for changes in body weight and morphology of the vagina, ovary, and uterus. A loss of cyclic activity and complete involution of uterus and vagina were observed between Week 9 and Week 27 after transfer into short photoperiods. During this time period, no corpora lutea were observed in the ovaries. Under the influence of short photoperiods, the numbers of medium and antral follicles declined continuously until Week 15, and afterwards gradually recovered to maximal numbers in Week 27. This biphasic response to short photoperiods was not observed in the number of small follicles. These morphological changes were accompanied by changes in serum and pituitary FSH concentrations. Pinealectomy prevented the loss of estrous cyclicity after transfer into short photoperiods. (ABSTRACT TRUNCATED AT 250 WORDS)
Branch Target Buffer Energy Reduction Through Efficient Multiway Branch Translation Techniques

Branch Target Buffer (BTB) plays an important role for pipelined processors in branch prediction during the execution of loops, if-then-else, call-return, and multiway branch statements. It has been observed that 20% of instructions in a program are related to branch. Access to BTB consumes 10% of total energy consumption of a program in execution. The present work introduces the use of K–d tree and pattern matcher to generate efficient code, i.e., lesser execution time, for multiway branch. However, instead of enhancing performance, Voltage Frequency Scaling (VFS) can be applied to achieve energy efficiency without degradation in performance. The present work is evaluated on a wide range benchmark programs. The BTB energy saving in the present work lies in the range 20% to 80% with small improvement performance as well. The total energy reduction is in the range 3–12%.
Validating an Inventory for the Assessment of Egoistic Bias and Moralistic Bias as Two Separable Components of Social Desirability

The psychometric properties of the German adaptation of the Balanced Inventory of Desirable Responding were investigated. This 2-factor inventory taps the egoistic bias and the moralistic bias as the 2 distinguishable components of social desirability. In 2 validation studies, both subscales showed satisfactory internal consistency and temporal stability. To examine convergent and discriminant validity, the scales were correlated with those of a measure of unrealistic optimism, various measures of self-enhancement, 1-dimensional scales of social desirability, and the tendency to overclaim in a test of general knowledge.
DOUBLEFACE: ROBUST REPUTATION RANKING BASED ON LINK ANALYSIS IN P2P NETWORKS

In this paper, we propose the DoubleFace algorithm to infer peers’ reputation rankings, which explicitly includes two phases. First is the computation of peers’ Recommendation Ability (RA) based on the following intuitive idea: Peer's RA will be reversely determined by how many peers it points to and how bad those peers have been rated, which comprise two subroutines: the badness propagation and the conversion of RA from badness. In the first subroutine, we thoroughly consider the effect of sybils’ attack on badness propagation, which has been investigated in previous work rarely; in the second subroutine, we design two methods to convert the badness into peer's RA: the disproportional way and the logistic way. The second phase is the integration of RA into adjacent matrix used to represent P2P trust graph, to reflect peer's RA in trust propagation. The simulation results show that the disproportional and logistic DoubleFace can be robust against sybils’ and front peers’ attacks to reputation ranking and can achieve significant performance improvement in comparison with Eigentrust-like algorithms, in hostile P2P environments. Moreover, we also discuss the effect of hostile and hospitable P2P environments on the performance of DoubleFace. Specifically, disproportional DoubleFace can perform slightly better than logistic DoubleFace in hostile P2P environments, but, in hospitable P2P environments, disproportional DoubleFace performs anti-intuitively poorly, and logistic DoubleFace achieves the same performance as traditional Eigentrust-like algorithms.
Matrix metalloproteinase 3 deletion preserves denervated motor endplates after traumatic nerve injury

Traumatic peripheral nerve injuries often produce permanent functional deficits despite optimal surgical and medical management. One reason for the impaired target organ reinnervation is degradation of motor endplates during prolonged denervation. Here we investigate the effect of preserving agrin on the stability of denervated endplates. Because matrix metalloproteinase 3 (MMP3) is known to degrade agrin, we examined the changes in endplate structure following traumatic nerve injury in MMP3 knockout mice.
Anti-endotoxin effects of terpenoids fraction from Hygrophila auriculata in lipopolysaccharide-induced septic shock in rats

Abstract Context: Hygrophila auriculata (K. Schum) Heine (Acanthaceae) has been traditionally used for the treatment of various ailments such as inflammation, rheumatism, jaundice and malaria. Objective: The present study aims to separate terpenoid fraction (TF) from alcohol (70%) extract of the whole plant of Hygrophila auriculata and assess its anti-inflammatory activity. Materials and methods: HPTLC analysis of TF was performed for the estimation of lupeol. Edema was induced in Wistar albino rats by subplanter injection of 0.1 ml of 1% (w/v) carrageenan into the right hind paw after 1 h of TF administration (100 and 200 mg/kg oral). Septic shock was induced by intraperitoneal administration of LPS (100 μg/kg) in rats and interleukins (IL-1β and IL-6), tumor necrosis factor (TNF-α), superoxide dismutase (SOD), lipid peroxidation (LPO), and nitric oxide (NO) were measured in serum. AutoDock 4.2 was used for molecular docking. Results: Administration of TF significantly (p < 0.005) restored the serum levels of cytokines, LPO (7.77 ± 0.034 versus 4.59 ± 0.059 nmole of TBARS), NO (9.72 ± 0.18 versus 4.15 ± 0.23 µmol nitrite/mg of wet tissue), and SOD (4.89 ± 0.036 versus 7.83 ± 0.033 Unit/mg protein) compared with the LPS-challenged rats. Analysis of in silico results revealed that TNF-α is the most appropriate target in eliciting anti-inflammatory activity. Conclusion: The present findings suggest that TF of Hygrophila auriculata possesses great promise as an anti-inflammatory agent which may be due to its antioxidant effect. Molecular docking results could be exploited for lead optimization and development of suitable treatment of inflammatory disorders.
CD31, EDNRB and TSPAN7 are promising prognostic markers in clear‐cell renal cell carcinoma revealed by genome‐wide expression analyses of primary tumors and metastases

Currently used clinicopathological parameters are insufficient for a reliable prediction of metastatic risk and disease‐free survival (DFS) of patients with clear‐cell renal cell carcinoma (ccRCC). To identify prognostic genes, the expression profiles of primary ccRCC obtained from patients with different DFS — eight synchronously, nine metachronously and seven not metastasized tumors — were determined by genome‐wide expression analyses. Synchronously and metachronously metastasized primary ccRCC differed in the expression of 167 genes. Thirty‐six of these genes were also differentially expressed in synchronously vs. metachronously developed pulmonary metastases analyzed in a previous study. Because of their DFS‐associated deregulation that is concordant in metastases and primary ccRCC, these genes are potentially functionally involved in metastatic tumor growth and are also prognostically useful. A prognostic impact was confirmed for the genes CD31, EDNRB and TSPAN7 at the mRNA level (n = 86), and for TSPAN7 at the protein level (n = 106). Patients with a higher gene expression of EDNRB or TSPAN7, or with TSPAN7‐positive vessels in both cores investigated on tissue microarrays had a significantly longer DFS and tumor‐specific survival (TSS). Patients with a higher CD31 gene expression showed a significantly longer TSS. EDNRB was an independent prognostic marker for the DFS. CD31, EDNRB and TSPAN7 had an independent impact on the TSS. In summary, comparative analysis of primary tumors and metastases is appropriate to identify independent prognostic markers in ccRCC. Gene expression of CD31 and EDNRB, and endothelial TSPAN7 protein level are potentially useful to improve outcome prediction because of their independent prognostic impact.
Novel technique for generating macrophage foam cells for in vitro reverse cholesterol transport studies[S]

Generation of foam cells, an essential step for reverse cholesterol transport studies, uses the technique of receptor-dependent macrophage loading with radiolabeled acetylated LDL. In this study, we used the ability of a biologically relevant detergent molecule, lysophosphatidylcholine (lyso-PtdCho), to form mixed micelles with cholesterol or cholesteryl ester (CE) to generate macrophage foam cells. Fluorescent or radiolabeled cholesterol/lyso-PtdCho mixed micelles were prepared and incubated with RAW 264.7 or mouse peritoneal macrophages. Results showed that such micelles were quite stable at 4°C and retained the solubilized cholesterol during one month of storage. Macrophages incubated with cholesterol or CE (unlabeled, fluorescently labeled, or radiolabeled)/lyso-PtdCho mixed micelles accumulated CE as documented by microscopy, lipid staining, labeled oleate incorporation, and by TLC. Such foam cells unloaded cholesterol when incubated with HDL but not with oxidized HDL. We propose that stable cholesterol or CE/lyso-PtdCho micelles would offer advantages over existing methods.
Neuro-inspired quantum associative memory using adiabatic hamiltonian evolution

It is widely believed that the real parallel computation achieved by quantum computers has an enormous computing potential. In order to expand its applicable field, we have investigated the fusion of quantum and neural computations. As a first step of implementing learning function on quantum computers, we have proposed a novel quantum associative memory (QuAM) by considering an analogy between neural associative network and qubit network. The memorizing procedure of the QuAM is realized with a Hamiltonian derived from qubit-qubit interactions, and the retrieving procedure is based on the adiabatic Hamiltonian evolution. The memory capacity of the QuAM has been nominally estimated as 2N−1 where N is a number of qubits, but its retrieve property has not been discussed in our previous study. This paper proposes a retrieving process for the QuAM and evaluates its performance in detail. The results indicate that the average of the retrieving probability is over 50% even when the qubit network memorizes 2N−1 patterns and thus the QuAM is successfully implemented.