Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantitative Analysis of Synaptic Contacts Made between Functionally Identified Oralis Neurons and Trigeminal Motoneurons in Cats

A previous study revealed that rostrodorsomedial oralis (Vo.r) neurons synapsing on trigeminal motoneurons use GABA and/or glycine as neurotransmitters. To determine the number and spatial distribution of contacts, injections of biotinamide and horseradish peroxidase were made into a Vo.r neuron and an α-motoneuron in the jaw-closing (JC) and jaw-opening (JO) motor nucleus, respectively, in 39 cats. All Vo.r neurons responded to low-threshold mechanical stimulation of the oral tissues. Single Vo.r neurons terminating in the JC nucleus (Vo.r-dl neurons;n = 5) issued, on average, 10 times more boutons than Vo.r neurons terminating in the JO nucleus (Vo.r-vm neurons;n = 5; 4437 vs 445). The Vo.r-dl neuron–JC α-motoneuron pairs (n = 4) made contacts on either the soma–dendritic compartment or dendrites, and the Vo.r-vm neuron–JO motoneuron pairs (n = 2) made contacts on dendrites, with a range of two to seven contacts. In five of the six pairs, individual or groups of two to three terminals contacted different dendritic branches of a postsynaptic cell. The Vo.r-dl neurons innervated a greater number of counter-stained motoneuronal somata than did the Vo.r-vm neurons (216 vs 26). Total number of contacts per Vo.r neuron was higher for the Vo.r-dl than Vo.r-vm neurons (786 vs 72). The present study demonstrates that axonal branches of Vo.r neurons are divided into two types with different innervation domains on the postsynaptic neuron and that they are highly divergent. The overall effect exerted by these neurons is predicted to be much greater within the JC than JO motoneuron pool.
Subplasma membrane Ca2+ signals

Ca2+ may selectively activate various processes in part by the cell's ability to localize changes in the concentration of the ion to specific subcellular sites. Interestingly, these Ca2+ signals begin most often at the plasma membrane space so that understanding subplasma membrane signals is central to an appreciation of local signaling. Several experimental procedures have been developed to study Ca2+ signals near the plasma membrane, but probably the most prevalent involve the use of fluorescent Ca2+ indicators and fall into two general approaches. In the first, the Ca2+ indicators themselves are specifically targeted to the subplasma membrane space to measure Ca2+ only there. Alternatively, the indicators are allowed to be dispersed throughout the cytoplasm, but the fluorescence emanating from the Ca2+ signals at the subplasma membrane space is selectively measured using high resolution imaging procedures. Although the targeted indicators offer an immediate appeal because of selectivity and ease of use, their limited dynamic range and slow response to changes in Ca2+ are a shortcoming. Use of targeted indicators is also largely restricted to cultured cells. High resolution imaging applied with rapidly responding small molecule Ca2+ indicators can be used in all cells and offers significant improvements in dynamic range and speed of response of the indicator. The approach is technically difficult, however, and realistic calibration of signals is not possible. In this review, a brief overview of local subplasma membrane Ca2+ signals and methods for their measurement is provided. © 2012 IUBMB IUBMB Life, 64(7): 573–585, 2012
Similar normalized Emax and O2 consumption-pressure-volume area relation in rabbit and dog.

The end-systolic pressure-volume relation (ESPVR), a measure of ventricular contractile state, and systolic pressure-volume area (PVA), a primary determinant of cardiac oxygen consumption per beat (VO2), have been derived from the pressure-volume diagram of the cross-circulated dog left ventricle. The slope of the PVA-VO2 relation represents the efficiency of chemomechanical energy transduction of the contractile machinery. To see whether these relationships were similar in other animals, we studied the isovolumic ESPVR and the VO2-PVA relation in nine excised, cross-circulated rabbit left ventricles. The base-line ESPVR was linear (r = 0.94-0.99) with the slope (Emax) and volume-axis intercept (V0) equal to 83.4 +/- 18.3 mmHg/ml and 0.43 +/- 0.17 ml, respectively. When normalized for left ventricular weight, Emax (4.1 +/- 1.1 mmHg.ml-1.100 g) and V0 (8.9 +/- 3.7 ml/100 g) were similar to values reported for the dog left ventricle. The correlation between PVA and VO2 was linear (r = 0.93-1.00), and the slope (1.90 X 10(-5) +/- 0.44 X 10(-5) ml O2.mmHg-1.ml-1) and VO2-axis intercept (0.040 +/- 0.009 ml O2.beat-1.100 g-1) were similar to values found in the dog left ventricle. Hence, despite the greatly different heart size, the base-line contractile state and chemomechanical energy conversion efficiency of the excised, cross-circulated rabbit left ventricle are similar to those of the dog left ventricle.
Relationship of visceral and subcutaneous adiposity with renal function in people with type 2 diabetes mellitus.

BACKGROUND Obesity and diabetes mellitus (DM) are established risk factors for the development of chronic kidney disease. Visceral adiposity (VAT) and subcutaneous adiposity (SAT) may be associated with the differential metabolic risk. Our study was performed to determine whether VAT or SAT was associated with the decrease of renal function in people with type 2 DM. METHODS Nine hundred and twenty-nine people with type 2 DM and who had undergone abdominal computed tomography assessment of the SAT and VAT areas were included. The estimated glomerular filtration rate (eGFR) was calculated using the Cockcroft-Gault equation and the Modification of Diet in Renal Disease (MDRD) four-variable equation at the time of the assessment of the SAT and VAT areas. RESULTS VAT was negatively associated with eGFR using the MDRD equation after adjustment for the clinical variables (β-coefficient = - 0.075, P = 0.034), while SAT was not significantly associated with eGFR. There was no significant association between the abdominal adiposity measurements and the eGFR using the Cockcroft-Gault formula. When stratifying the individuals by the body mass index groups, VAT was negatively associated with eGFR by the MDRD equation and the Cockcroft-Gault formula in the overweight and obese subjects after adjustment for the clinical variables, while there was no significant association between the VAT and the eGFR in the normal weight subjects. SAT was not significantly associated with eGFR in the normal weight, overweight and obese subjects. CONCLUSIONS Our data suggest that VAT may be an additional prognostic factor for the decrease of renal function especially in the overweight or obese subjects with type 2 DM.
Conjugate Mixture Models for the Modeling of Visual and Auditory Perception. (Modèles de Mélanges Conjugués pour la Modélisation de la Perception Visuelle et Auditive)

In this thesis, the modelling of audio-visual perception with a head-like device is considered. The related problems, namely audio-visual calibration, audio-visual object detection, localization and tracking are addressed. A spatio-temporal approach to the head-like device calibration is proposed based on probabilistic multimodal trajectory matching. The formalism of conjugate mixture models is introduced along with a family of efficient optimization algorithms to perform multimodal clustering. One instance of this algorithm family, namely the conjugate expectation maximization (ConjEM) algorithm is further improved to gain attractive theoretical properties. The multimodal object detection and object number estimation methods are developed, their theoretical properties are discussed. Finally, the proposed multimodal clustering method is combined with the object detection and object number estimation strategies and known tracking techniques to perform multimodal multiobject tracking. The performance is demonstrated on simulated data and the database of realistic audio-visual scenarios (CAVA database).
COMPUTATION OF REGIONAL TRAVEL TIMES AND STATION CORRECTIONS FROM THREE-DIMENSIONAL VELOCITY MODELS

We have investigated the performance of a variety of methods to compute travel times at regional distances for heterogeneous three-dimensional velocity models of the Earth’s crust and upper mantle. Ray-shooting and finite-difference methods give good results for the type of 3-D models analyzed. For S waves, the differences between methods are on the order of 0.5 seconds, which is sufficient for the generation of model-predicted station correction surfaces. The differences in travel times are mostly caused by the diversity in internal model representation between the travel time codes. For the models analyzed, the influence of offgreat-circle propagation is small, particularly when compared to the differences in travel times between methods. Therefore, computations can be carried out in 2-D. For the purpose of calculating model-predicted stations corrections, the reference model of the 3-D model should be as close as possible to the 1-D reference model of the correction surface to avoid significant artifacts.
Consistent estimation of the fixed effects ordered logit model

The paper considers panel data methods for estimating ordered logit models with individual‐specific correlated unobserved heterogeneity. We show that a popular approach is inconsistent, whereas some consistent and efficient estimators are available, including minimum distance and generalized method‐of‐moment estimators. A Monte Carlo study reveals the good properties of an alternative estimator that has not been considered in econometric applications before, is simple to implement and almost as efficient. An illustrative application based on data from the German Socio‐Economic Panel confirms the large negative effect of unemployment on life satisfaction that has been found in the previous literature.
Identification of a non‐basic domain in the histone H4 N‐terminus required for repression of the yeast silent mating loci.

We have shown previously that a stretch of four charged residues (16–19) at the histone H4 N‐terminus is involved in repression of the yeast silent mating loci. One of these residues, Lys16, is a site for acetylation, which may prevent repression of the silent mating loci. In this paper we ask whether other sequences in histone H4, possibly in conjunction with H3 residues, are required for repression. We find that even in combination, the other seven acetylatable lysines in H3 and H4 do not function in repression. In contrast, we have found that an adjacent relatively uncharged domain (residues 21–29) is required for repression and that single amino acid insertions and deletions in this region are extremely detrimental. We propose that the basic and non‐basic domains together form a DNA (or protein) induced amphipathic alpha‐helix required in the formation of a repressive chromatin structure.
Stellar Sources for Heavy r-Process Nuclei

The stellar sites and the complete mechanism of r-process nucleosynthesis are still unresolved issues. From consideration of the observed abundances in metal-poor stars, it is proposed that the production of heavy r-process nuclei (r-nuclei with mass numbers A > 130) is not related to the production of Fe group elements or of elements with lower atomic numbers: Na, Mg, Al, Si, Ca, Sc, and Ti. This requires that the production of heavy r-nuclei not occur in supernovae with extended shell structure but be associated with either bare neutron stars or Type II supernovae (SNe II) in the mass range 8 M☉ < M < 10 M☉. From the observations of stars with [Fe/H] ~ -3 but with high abundances of r-elements, it is clear that these r-process enrichments cannot represent the composition of the interstellar medium from which the stars were formed but must represent very local contamination from binary companions. Further evidence for very high enrichments of s-process elements in metal-poor stars also requires binary systems for explanation. We propose that the accretion-induced collapse (AIC) of a white dwarf into a neutron star in a binary system may be associated with the production of heavy r-nuclei and may provide occasional coupling of high r-process and high s-process enrichments in the envelopes of low-mass stars with low [Fe/H]. If we assume that the bulk of the heavy r-nuclei are produced in AIC events, then these events would have produced ~1.6 × 109 neutron stars in the Galaxy. A much larger number of white dwarf binaries would have resulted from the evolution of other binary systems. The AIC scenario removes the assignment in our earlier model that SNe II provide the bulk of heavy r-nuclei and relegates r-process production in SNe II to light r-nuclei with A ≲ 130. This new assignment gives Fe yields that are in accord with the observed values for most SNe II.
Transport and stirring induced by vortex formation

The purpose of this study is to analyse the transport and stirring of fluid that occurs owing to the formation and growth of a laminar vortex ring. Experimental data was collected upstream and downstream of the exit plane of a piston-cylinder apparatus by particle-image velocimetry. This data was used to compute Lagrangian coherent structures to demonstrate how fluid is advected during the transient process of vortex ring formation. Similar computations were performed from computational fluid dynamics (CFD) data, which showed qualitative agreement with the experimental results, although the CFD data provides better resolution in the boundary layer of the cylinder. A parametric study is performed to demonstrate how varying the piston-stroke length-to-diameter ratio affects fluid entrainment during formation. Additionally, we study how regions of fluid are stirred together during vortex formation to help establish a quantitative understanding of the role of vortical flows in mixing. We show that identification of the flow geometry during vortex formation can aid in the determination of efficient stirring. We compare this framework with a traditional stirring metric and show that the framework presented in this paper is better suited for understanding stirring/mixing in transient flow problems. A movie is available with the online version of the paper.
Navigation in hybrid metric-topological maps

We present an approach for navigation in hybrid maps consisting of a topological graph overlaid with local occupancy grids. The topological graph is built on top of a graph SLAM system, which can be efficiently optimized even for very large environments. The novel feature of our system is that it navigates locally using local metric maps, while the overall plan is formed on the topological graph. Unlike many current SLAM methods, we never reconstruct a full occupancy grid of the environment for localization or path planning. We show that our method generates near-optimal plans, and deals gracefully with changes to the map.
A pattern recognition system for handoff algorithms

In wireless cellular systems, handoff algorithms decide when and to which base station to handoff. Traditional handoff algorithms generally cannot keep both the average number of unnecessary handoffs and the handoff decision delay low. They do not exploit the relative constancy of path loss and shadow fading effects at any given location around a base station. This information can in fact be used to improve the efficiency of handoff algorithms, as we do in our new handoff algorithms using statistical pattern recognition. Handoff algorithms with both a negligible number of unnecessary handoffs and a negligible decision delay can therefore be realized.
High Density Asynchronous LUT Based on Non-volatile MRAM Technology

In this article, we present the architecture design of high-performance Asynchronous Look Up Table (LUT) embedded with a non-volatile Magnetic RAM (MRAM) as the configuration memory, called MALUT. It promises a number of advantages over the traditional FPGA circuits such as “free” standby power, high operating frequency and instant on/off etc. Thanks to the 3D integration and high density of MRAM, fine-grain run-time reconfiguration and multi-context configuration can be achieved. An automatic design flow has been developed for the design of complex hybrid CMOS/MRAM circuits. Based on CMOS 130nm and MRAM 120nm technology, mixed simulations and layout implementation have been done to demonstrate the expected operation and configuration performances. At last, we discuss and conclude.
An enhanced 3DCNN‐ConvLSTM for spatiotemporal multimedia data analysis

At present, human action recognition is a challenging and complex task in the field of computer vision. The combination of CNN and RNN is a common and effective network structure for this task. Especially, we use 3DCNN in CNN part and ConvLSTM in RNN part. We divide the video into multiple temporal segments by average and compress each segment into one feature map by pooling layer. Adding the pooling layer, dropout layer, and batch normalization layer into ConvLSTM is our groundbreaking work. We test our model on KTH, UCF‐11, and HMDB51 datasets and achieve a high accuracy of action recognition.
What Is the Optimal Network Deployment for a Fixed Density of Antennas?

In this paper, we answer a fundamental question: when the total number of antennas per square kilometer is fixed, what is the optimal network deployment? A denser network with a less number of antennas per base station (BS) or the opposite case. To evaluate network performance, we consider a practical network scenario with a fixed antennas density and multiuser multiple-input-multiple- output (MU-MIMO) operations for single-antenna users. The number of antennas in each BS is calculated by dividing the antenna density by the BS density. With the consideration of several practical network models, i.e., pilot contamination, a limited user equipment (UE) density and probabilistic line-of-sight (LoS)/non- line-of-sight (NLoS) path loss model, we evaluate the area spectral efficiency (ASE) performance. From our simulation results, we conclude that there exists an optimal BS density for a certain UE density to maximize the ASE performance when the antenna density is fixed. The intuition is that (i) by densifying the network with more BSs, we can achieve a receive power gain due to the smaller distance between the typical UE and its serving BS; (ii) by installing more antennas in each BS, we can achieve a beamforming gain for UEs using MU-MIMO, although such beamforming gain is degraded by pilot contamination; (iii) thus, a trade-off exists between the receive power gain and the beamforming gain, if we fix the antenna density in the network.
An artificial neural network based approach for online string matching/filtering of large databases

A novel online approach to exact string matching and filtering of large databases is presented. String matching/filtering is based on artificial neural networks and operates in two stages: initially, a self‐organizing map retrieves the cluster of database strings that are most similar to the query string; subsequently, a harmony theory network compares the retrieved strings with the query string and determines whether an exact match exists. The similarity measure is configured to the specific characteristics of the database so as to expose overall string similarity rather than character coincidence at homologous string locations. The experimental results demonstrate foolproof, fast, and practically database‐size independent operation that is especially robust to database modifications. The proposed approach is put forward for general‐purpose (directory, catalogue, glossary search) as well as Internet‐oriented (e‐mail blocking, URL, username classification) applications. © 2010 Wiley Periodicals, Inc.
Lower Variability of Tacrolimus Trough Concentration After Conversion From Prograf to Advagraf in Stable Kidney Transplant Recipients

Backgrounds. Variability of blood trough concentration (C0) in immunosuppressant leads to rejection and graft loss after kidney transplantation. Methods. The aim of this study is to prospectively investigate the change of within-patient variability among stable kidney transplant recipients with conversion from twice-daily Prograf to the same milligram-for-milligram daily dose of once-daily Advagraf. Results. The mean age of 129 patients was 51.3±12.1 years. The conversion to Advagraf was administrated at 6.3±4.8 years after transplantation. The daily dose was changed from 4.7±2.0 mg to 4.9±2.1 mg after conversion. Only six patients increased daily dose by 16.7% to 25% to maintain target levels. The whole blood C0 of tacrolimus before conversion was 5.9±1.7 ng/mL. The mean C0 was significantly reduced after conversion to Advagraf; it was 4.9±1.5 ng/mL on the seventh day (P<0.001) and 5.4 to 5.5 ng/mL at 1 to 6 months (P<0.05). Forty-one (31.8%) patients have reduced C0 of more than 25% on the seventh day. The percent coefficient of variation of tacrolimus C0 more than 22.5% before conversion is associated with higher risk of reduced C0 after conversion (P<0.05). Compared with before conversion, less kidney transplant recipients have percent coefficient of variation more than 22.5% after conversion (3.1% vs. 17.4% with P<0.01). Conclusions. The results support that conversion from Prograf to Advagraf among kidney transplant recipient leads to a significantly lower C0 and within-patient variability of tacrolimus C0. The within-patient variability of C0 before conversion influences C0 on the sevent day after conversion to Advagraf.
The effectiveness of teaching and learning programming using Embedded System

Programming is undoubtedly one of the most important skills needed in the field of information technology as the use of IT requires applications that can only be developed through programming. However, the number of programmers in Malaysia is still low. Most often, Malaysia imports programmers from abroad such as Indonesia and India to serve its need in system development. This occurs because even for students who are studying IT or computer science, programming is not a career option. To overcome this problem, the government of Malaysia has taken the initiative to introduce the subject of ICT and Computer Programming courses in schools. The initiative however is still unable to attract the desired number of students to programming. Thus Embedded Systems Programming (ESP) module is developed to attract students to programming. ESP module is not much different from the existing modules for C programming, but it uses electronic components, such as LED, LCD, 7-segment display and motors as output. Testing on the effectiveness of the modules was conducted at four schools that comprise the overall participation of 71 students. Students were taught three days modules and learning outcomes were assessed based on quizzes, survey questions and observations by the instructors. The results received were positive by looking at the students' achievements and commitment in learning this subject.
Long Term Evolution and Optimization based Downlink Scheduling

necessity for high data rate mobiles is fast growing. New data steam applications, online gaming and high speed applications are very quickly evolved. The Third Generation Partnership Project (3GPP) offered a full network solution to increase the data rate. This network solution called Long Term Evolution (LTE). LTE can support high data rates up to 100 Mbps for downlink and 50 Mbps for uplink.To reach this high data rate, time and frequency shared resources must be appointed to user equipments (UEs) in right way. LTE has several downlink scheduling algorithms for assigning the resources. In this paper the analysis of "Round Robin" and Best Channel Quality Indicator (CQI) are carried . and the comparisons are applied through a MATLAB based simulator. Keywordsnetwork ,Round Robin ,CQI,simulation.