Miracle-dz/UniFAR-FTUs huggingface dataset:
Design and measurement of Band V WCDMA LNA utilizing design kit with scalable parametric cell inductors

A low-noise amplifier (LNA) integrated circuit (IC) has been designed and implemented on a 0. 13μm RF CMOS process technology. The performance of the LNA has been targeted to exceed WCDMA standard specification. This paper presents the design methodology and compares the simulated and measurement results of the cascode LNA with inductive degeneration. There were expected mismatch between simulation and measurement data, thus some of the matching elements were intentionally placed outside of the chip. Additionally, target frequency on simulation was designed at a general 850MHz frequency but later on measurement the target frequency was moved close to the center of receive frequency of Band V of WCDMA. On the simulation, at resonance frequency of 850MHz the NF is 0.54dB, 1dB input compression point is −26.67dBm and S21 is 27.86dB. On measurement where impedance matching were done exactly as in simulation with the exception in value of quality factor Q of the external passive devices, the NF about 2dB, 1dB input compression point is −25.3dB and S21 is 18dB at 875MHz. Value of LS and LG were adjusted to move peak of S21 to be at almost the new target frequency of 881.5MHz. Measurement result after impedance was matched to the band V receive center frequency, S21 has dropped to 13.37dB, NF has jumped to 2.65dB but linearity improved where 1dB input compression point has increased to −18.14dBm mainly because the drop in S21.
Alpha and Lambda Interferon Together Mediate Suppression of CD4 T Cells Induced by Respiratory Syncytial Virus

ABSTRACT The mechanism by which respiratory syncytial virus (RSV) suppresses T-cell proliferation to itself and other antigens is poorly understood. We used monocyte-derived dendritic cells (MDDC) and CD4 T cells and measured [3H]thymidine incorporation to determine the factors responsible for RSV-induced T-cell suppression. These two cell types were sufficient for RSV-induced suppression of T-cell proliferation in response to cytomegalovirus or Staphylococcus enterotoxin B. Suppressive activity was transferable with supernatants from RSV-infected MDDC and was not due to transfer of live virus or RSV F (fusion) protein. Supernatants from RSV-infected MDDC, but not MDDC exposed to UV-killed RSV or mock conditions, contained alpha interferon (IFN-α; median, 43 pg/ml) and IFN-λ (approximately 1 to 20 ng/ml). Neutralization of IFN-α with monoclonal antibody (MAb) against one of its receptor chains, IFNAR2, or of IFN-λ with MAb against either of its receptor chains, IFN-λR1 (interleukin 28R [IL-28R]) or IL-10R2, had a modest effect. In contrast, blocking the two receptors together markedly reduced or completely blocked the RSV-induced suppression of CD4 T-cell proliferation. Defining the mechanism of RSV-induced suppression may guide vaccine design and provide insight into previously uncharacterized human T-cell responses and activities of interferons.
SUMO‐1 modification activates the transcriptional response of p53

The p53 tumour suppressor protein is regulated by ubiquitin‐mediated proteasomal degradation. In normal cells p53 is constitutively ubiquitylated by the Mdm2 ubiquitin ligase. When the p53 response is activated by stress signals p53 levels rise due to inhibition of this degradative pathway. Here we show that p53 is modified by the small ubiquitin‐like protein SUMO‐1 at a single site, K386, in the C‐terminus of the protein. Modification in vitro requires only SUMO‐1, the SUMO‐1 activating enzyme and ubc9. SUMO‐1 and ubiquitin modification do not compete for the same lysine acceptor sites in p53. Overexpression of SUMO‐1 activates the transcriptional activity of wild‐type p53, but not K386R p53 where the SUMO‐1 acceptor site has been mutated. The SUMO‐1 modification pathway therefore acts as a potential regulator of the p53 response and may represent a novel target for the development of therapeutically useful modulators of the p53 response.
Automated flicker perimetry in glaucoma using Octopus 311: a comparative study with the Humphrey Matrix.

PURPOSE We evaluated the clinical usefulness of flicker perimetry in glaucoma and glaucoma suspect patients using the new Octopus 311 automated perimeter. METHODS A total of 52 eyes of 52 glaucoma patients, 26 eyes of 26 glaucoma suspect patients and 61 eyes of 61 normal subjects were examined using standard automated perimetry (SAP), flicker perimetry and frequency doubling technology (FDT) perimetry. Flicker perimetry was performed using the Octopus 311 and its remote software package. Suprathreshold four-zone probability strategy was used to classify the critical fusion frequency probability level. The classified levels were set at 5% and 1% of probability of normality and 5 Hz. Frequency doubling technology perimetry was performed using 24-2-5, 24-2-1, N-30-5, N-30-1 screening programs using Humphrey Matrix perimetry. Standard automated perimetry was performed using the Humphrey field analyser program 24-2 full threshold. Optical coherence tomography using Stratus OCT was used for evaluating the retinal nerve fibre layer thickness in all glaucoma and glaucoma suspect patients. RESULTS Receiver operating characteristic (ROC) curves were calculated. In the early stage of glaucoma, the areas under the ROC curve (AUCs) were 0.96 in flicker and 0.90 in Matrix perimetry. In the moderate and advanced stages of glaucoma, the AUCs were almost 1.0 in all tests. In glaucoma suspect patients, the AUC of the 5% probability level in flicker was significantly higher than in Matrix perimetry. CONCLUSION The four-zone probability strategy using the Octopus 311 is a useful method for evaluating the flicker field in early glaucoma and glaucoma suspect patients.
Stoichiometry of cellular and viral components in the polyomavirus middle-T antigen-tyrosine kinase complex

Our results indicate that only one type of tyrosine kinase is present within each middle-T antigen-tyrosine kinase complex, suggesting that middle-T antigen forms separate complexes with different tyrosine kinases. Furthermore, we determined that there is only one molecule of middle-T antigen within any one of these complexes. We interpret this to mean that in any given cell, polyomavirus transformation involves, at least in part, the simultaneous deregulation of a number of separate pathways controlling cellular proliferation. Finally, we also demonstrate that the separate middle-T:pp60c-src and middle-T:pp59c-fyn complexes are each able to interact with the same cellular p81/85-kDa phosphoprotein, a possible component of the phosphatidylinositol kinase.
Dynamic buffer overflow detection for GPGPUs

Buffer overflows are a common source of program crashes, data corruption, and security problems. In this work, we demonstrate that GPU-based workloads can also cause buffer overflows, a problem that was traditionally ignored because CPUs and GPUs had separate memory spaces. Modern GPUs share virtual, and sometimes physical, memory with CPUs, meaning that GPU-based buffer overflows are capable of producing the same program crashes, data corruption, and security problems as CPU-based overflows. While there are many tools to find buffer overflows in CPU-based applications, the shift towards GPU-enhanced programs has expanded the problem beyond their capabilities. This paper describes a tool that uses canaries to detect buffer overflows caused by GPGPU kernels. It wraps OpenCL™ API calls and alerts users to any kernel that writes outside of a memory buffer. We study a variety of optimizations, including using the GPU to perform the canary checks, which allow our tool to run at near application speeds. The resulting runtime overhead, which scales with the number of buffers used by the kernel, is 14% across 175 applications in 16 GPU benchmark suites. In these same suites, we found 13 buffer overflows in 7 benchmarks.
Rothamsted Repository Download

Sulfate uptake and distribution in plants are managed by the differential expression of a family of transporters, developmentally, spatially, and in response to sulfur nutrition. Elucidation of the signaling pathways involved requires a knowledge of the component parts and their interactions. Here, the expression patterns of the full complement of sulfate transporters in wheat, as inﬂuenced by development and sulfur nutrition, are described. The 10 wheat sulfate transporters characterized here are compared to the gene families for both rice and Brachypodium , for whom full genome information is available. Expression is reported in young seedlings with a focus on roles in uptake from nutrient solution and differential expression in relation to sulfate deprivation. In addition, patterns of expression in all organs at the grain ﬁlling stage are reported and indicate differential responses to nutritional signals of the individual transporters in speciﬁc tissues and an overall coordination of uptake, storage, and remobilization to deliver sulfur to the developing grain.
Mobile User Network Behavior Analysis Based on Improved Fuzzy C-Means Clustering

Because the traditional mobile user network behavior analysis lacks of data mining and analysis means, which leads to corporate market and user demand separated. So, we propose an integrated approach and find an effective solution based on fuzzy c-means to analyze the mobile user network behavior. Because FCM algorithm is easy to fall into local minimum value and is sensitive to the initial value, we propose a kind of improved fuzzy c-means clustering algorithm based on artificial fireflies. The artificial firefly with global optimization ability is used to obtain the optimal solution, which is taken as the initial clustering center of FCM algorithm. The experiment results show that the proposed scheme has good result.
Prospective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study.

BACKGROUND Although hemostatic factors contribute to acute coronary syndromes and atherogenesis, few studies have prospectively evaluated the association between multiple hemostatic factors and coronary heart disease incidence. METHODS AND RESULTS The Atherosclerosis Risk in Communities Study recruited 14,477 adults from 45 to 64 years of age who were initially free of coronary heart disease. Coronary disease risk factors and several plasma hemostatic factors were measured, and incidence of coronary heart disease was ascertained during an average follow-up of 5.2 years. Age-, race-, and field center-adjusted relative risks of coronary heart disease were significantly elevated (P < or = .05) per higher value of fibrinogen (relative risk: men, 1.76; women, 1.54), white blood cell count (men, 1.68; women, 2.23), factor VIII coagulant activity (women, 1.25), and von Willebrand factor antigen (men, 1.20; women, 1.18). Adjustment for other risk factors attenuated these associations for fibrinogen (adjusted relative risk: men, 1.48; women, 1.21), and it eliminated the white blood cell count, factor VIII, and von Willebrand factor associations, consistent with the other risk factors either confounding or partly operating through their effects on the hemostatic variables. Adjusted standardized relative risks of total mortality, ranging from 1.13 to 1.37, were also elevated (P < .05) in relation to these four factors. There was no association of coronary disease incidence with factor VII, protein C, antithrombin III, or platelet count. CONCLUSIONS Elevated levels of fibrinogen, white blood cell count, factor VIII, and von Willebrand factor are risk factors and may play causative roles in coronary heart disease. However, their measurement in healthy adults appears to add little to prediction of coronary events beyond that of more established risk factors.
An intelligent ant colony optimization for community detection in complex networks

Many systems in social world can be represented by complex networks. It is of great significance to detect the community structure and analyze the functions for networks. In recent years, plenty of research and works have been focused on this problem. In this paper, we propose an enhanced algorithm based on ant colony optimization (ACO) for the community detection problems. In order to avoid redundant computing in ACO, we divide the ant colony into two groups, original group and intelligent group, which search the solution space simultaneously. In the intelligent group, due to the locus-based adjacency representation of the solution, we let some of them have an ability of self-learning and others can learn from the optimal solutions proactively. Experiments on synthetic and real-life networks show the proposed algorithm can explore in an efficient and stable way.
Physical Activity, Hormone Replacement Therapy, and the Presence of Coronary Calcium in Midlife Women

Background: Atherosclerotic calcification is a risk factor for cardiovascular events, independent of other traditional risk factors. Studies of the relation of menopausal hormone therapy to cardiovascular events have had inconsistent results, and often have been confounded by lifestyle behaviors and the “healthy user” effect. The authors evaluated the cross-sectional association of hormone therapy use with the presence and severity of atherosclerosis in postmenopausal women, independent of lifestyle factors, including diet and physical activity levels. Methods: The authors consecutively enrolled postmenopausal asymptomatic women who were referred for coronary artery calcium scanning to measure cardiovascular risk. After consent was obtained, women were interviewed prior to their cardiac scan about cardiac risk factors, hormone therapy use, menopausal status, diet, and physical activity. Coronary artery calcium prevalence was defined as any calcification present (score >0). Results: Of the 544 enrolled women aged 50–80 years, 252 (46.3%) were hormone therapy users. Hormone therapy users had a significantly lower prevalence of any coronary artery calcium (defined as coronary artery calcium score >0; 37%), than non-users (50%, p = 0.04), as well as significantly lower mean calcium scores (p = 0.02). Multiple logistic regression models demonstrated a significantly reduced odds of coronary artery calcium in hormone therapy users compared to non-users with an adjusted odds ratio of 0.58 (p = 0.04), adjusting for traditional cardiac risk factors and body mass index. Women who reported consuming a vegetarian or a high-protein diet had almost two-fold odds of coronary artery calcium compared with women who reported regular, mixed, or low-fat, low-salt diets (OR = 1.78, p = 0.02). Severity of coronary artery calcium was less with increasing levels of physical activity, and a significant association was observed between physical activity and hormone therapy use (adjusted OR = 4.05, p = 0.03), independent of coronary artery calcium severity. Conclusion: This cross-sectional study demonstrated a protective association of hormone therapy with the presence and severity of coronary artery calcium. Although a strong relationship was observed between hormone therapy and physical activity, their complex interplay may affect mechanistic biochemical and physiological processes that have yet to be clearly delineated. Thus, physical activity and diet should be taken into account in prospective studies of the relation of hormone therapy use to coronary artery calcium.
Lys48 ubiquitination during the intraerythrocytic cycle of the rodent malaria parasite, Plasmodium chabaudi

Ubiquitination tags proteins for different functions within the cell. One of the most abundant and studied ubiquitin modification is the Lys48 polyubiquitin chain that modifies proteins for their destruction by proteasome. In Plasmodium is proposed that post-translational regulation is fundamental for parasite development during its complex life-cycle; thus, the objective of this work was to analyze the ubiquitination during Plasmodium chabaudi intraerythrocytic stages. Ubiquitinated proteins were detected during intraerythrocytic stages of Plasmodium chabaudi by immunofluorescent microscopy, bidimensional electrophoresis (2-DE) combined with immunoblotting and mass spectrometry. All the studied stages presented protein ubiquitination and Lys48 polyubiquitination with more abundance during the schizont stage. Three ubiquitinated proteins were identified for rings, five for trophozoites and twenty for schizonts. Only proteins detected with a specific anti- Lys48 polyubiquitin antibody were selected for Mass Spectrometry analysis and two of these identified proteins were selected in order to detect the specific amino acid residues where ubiquitin is placed. Ubiquitinated proteins during the ring and trophozoite stages were related with the invasion process and in schizont proteins were related with nucleic acid metabolism, glycolysis and protein biosynthesis. Most of the ubiquitin detection was during the schizont stage and the Lys48 polyubiquitination during this stage was related to proteins that are expected to be abundant during the trophozoite stage. The evidence that these Lys48 polyubiquitinated proteins are tagged for destruction by the proteasome complex suggests that this type of post-translational modification is important in the regulation of protein abundance during the life-cycle and may also contribute to the parasite cell-cycle progression.
THE IMPACT OF FARM MECHANIZATION ON SMALL-SCALE RICE PRODUCTION

TAN, YOLANDA L . , U n i v e r s i t y of t h e P h i l i p p i n e s a t Los Bafios, March 1981. The Impact of Farm Mechanizat ion on Smalls c a l e Rice Produc t ion . T h e s i s a d v i s e r : D r . B a r t Duff . The o b j e c t i v e of t h i s s t u d y i s t o q u a n t i t a t i v e l y a s s e s s t h e impact of farm mechanizat ion on o u t p u t . P roduc t ion e f f e c t s of mechanizat ion were e v a l u a t e d through t h e u s e of decomposi t ion a n a l y s e s . F i r s t , an a r i t h m e t i c decomposi t ion a n a l y s i s was employed t o d i s a g g r e g a t e o u t p u t d i f f e r e n c e s between mechanized and non-mechanized farms i n t o i t s component e l e m e n t s , i . e . , , . y i e l d , p r i c e , a r e a and c ropp ing i n t e n s i t y component p l u s t h e i n t e r a c t i o n s of t h e s e components. R e s u l t s of t h e a n a l y s i s showed t h a t t h e most impor tan t f a c t o r s t h a t brought abou t o u t p u t d i f f e r e n c e s between t h e mechar~ized and non-mechanized farms were c ropp ing i n t e n s i t y and y i e l d . Secondly, y i e l d e f f e c t of mechanizat ion was i n v e s t i g a t e d by u s i n g a n o t h e r decomposi t ion t echn ique employing a p roduc t ion f u n c t i o n framework. The model decomposed t o t a l y i e l d d i f f e r e n c e s between t h e mechanized and nan-mechanized farms i n t o t h e technol o g i c a l change component and change i n t h e u s e of i n p u t s component . The r e s u l t s of t h e a n a l y s i s showed t h a t t h e major s o u r c e of y i e l d d i f f e r e n c e s between t h e e . 7 0 farm t y p e s WAS brought about by non-neutral technical change, i . e . , s h i f t i n the slope coef f i c i ents of the production functions, which means differences in the a l locat ion of resources of the two farms.
The Topographic Organization and Axis of Projection within the Visual Sector of the Rabbit's Thalamic Reticular Nucleus

The organization of the visual field representation within the thalamic reticular nucleus (TRN) of the rabbit was studied. Focal injections of horseradish peroxidase (HRP) and/or [3H]proline were made into visuocortical areas V1 and V2 and the dorsal lateral geniculate nucleus (dLGN). The resultant labelling in the thalamus was analysed.
Defining student participation and empowerment in higher education

Customer participation has been studied for decades; however, it gained a postmodern perspective around the year 2000. Customers have become co-creators of personalized experiences, moving from the audience to the stage. In the educational context, students must take responsibility for their learning process and participate in the production of the service. This changing is providing opportunities and challenges for higher education institutions (HEIs) to redefine their relationship with stakeholders, especially with students. This study is based on the service dominant logic (SDL) perspective because students are assumed to take the role of co-creators of knowledge in the educational setting. The research uses adapted frameworks and concepts applied in organizational, knowledge-intensive business services (KIBS) and also medical studies to advance the understanding of value co-creation in the HEI context. The current study addresses a lack of research in the higher education context focusing on defining students’ participation and students’ empowerment in higher education context. An empirical investigation was developed with traditional schools in Brazil. This investigation allowed the description of the constructs in the specific context. The description of student participation in HEIs context reflects the relevance of three dimensions – information sharing, personal interaction and responsible behavior. In the Brazilian context, responsible behavior is the weakest dimension in the construct, because the responsibilities are unbalanced between students and professors. The main reasons identified for this unbalanced relation were cultural issues and local regulation. Student empowerment was described as composed by four dimensions – meaningfulness, competence, impact and choice; however, one of them – choice – was identified as the weakest dimension, facing cultural and bureaucratic barriers for implementation in the Brazilian educational context. Moreover, interviewees spontaneously cited the idea of trust in the faculty as an important antecedent of student participation that must be considered when analyzing student participation and empowerment mechanisms. An additional contribution was the proposal of a theory-based framework for understanding the service dominant logic perspective in the HEI context, in which student participation and student empowerment were explored as mechanisms leading to positive student behavior toward institution.
Nonsmooth Newton Method for Fischer Function Reformulation of Contact Force Problems for Interactive Rigid Body Simulation

In interactive physical simulation, contact forces are applied to prevent rigid bodies from penetrating each other. Accurate contact force determination is a computationally hard problem. Thus, in practice one trades accuracy for performance. The result is visual artifacts such as viscous or damped contact response. In this paper, we present a new approach to contact force determination. We reformulate the contact force problem as a nonlinear root search problem, using a Fischer function. We solve this problem using a generalized Newton method. Our new Fischer– Newton method shows improved qualities for speciﬁc conﬁgurations where the most widespread alternative, the Projected Gauss-Seidel method, fails. Experiments show superior convergence properties of the exact Fischer– Newton method.
Sub-0.1-eV Effective Schottky-Barrier Height for NiSi on n-Type Si (100) Using Antimony Segregation

We report a new method of forming nickel silicide (NiSi) on n-Si with low contact resistance, which achieves a Schottky barrier height of as low as 0.074 eV. Antimony (Sb) and nickel were introduced simultaneously and annealed to form NiSi on n-Si (100). Sb dopant atoms were found to segregate at the NiSi/Si interface. The devices with Sb segregation show complete nickel monosilicide formation on n-Si (100) and a close-to-unity rectification ratio. The rectification ratio Rc is defined to be the ratio of the forward current to the reverse current, where the forward and reverse currents are measured using forward and reverse bias voltages, respectively, having the same magnitude of 0.5 V. This process is also compatible and easily integrated in a CMOS fabrication process flow.