Miracle-dz/UniFAR-FTUs huggingface dataset:
Spontaneous Mirror Symmetry Breaking in Nature and the Origin of Life

Theoretical and experimental studies of the problem of mirror symmetry breaking in Nature in the course of the origin of life are discussed.The interplay of three main factors—statistical fluctuations, advantage factor (AF) and racemizing processes is taken into account.The detailed analysis of existing data leads to the following scheme of main stages of the formation of life: 1. Prebiotic monomer formation, i.e., the formation and accumulation of various components of future biopolymers in racemic form (‘‘warm‘‘‐terrestrial, and ‘‘cold’’‐extraterrestrial scenarios are discussed). 2. Chiral purity formation, i.e., the cooperative bifurcation‐type chiral polarization of the prebiotic medium. The sign of such polarization at the Earth (D‐sugars and L‐amino acids) seems to be accidental rather than determined by the violation of parity in weak interactions. 3. Formation of oligomeric tracers of chiral specific activity, i.e., the formation of protobiological structures (apparently, starting with RNA) up to .
Subspace clustering with a learned dimensionality reduction projection

Subspace clustering aims to separate data from a union of low dimensional linear subspaces. Many recent subspace clustering methods based on self-representation are popular and achieve state-of-art performance. Dimensionality reduction is a common preprocessing procedure before applying these clustering methods. In this paper, we present an algorithm to segment subspaces with a learned dimensionality reduction projection instead of simply using PCA (Principal Component Analysis). We propose an objective function which simultaneously learns the dimensionality reduction projection and self-representation coefficients. We integrate SMR (Smooth Representation subspace clustering) into this framework and propose SMR_LP (Smooth Representation clustering with Learned Projection). We also propose an efficient method to optimize the cost function. A well learned projection helps preserving the data structure and improves the clustering performance. Experimental results demonstrate the effectiveness of our proposed method.
Intestinal colonization of the infant mouse model by attenuated and virulent Vibrio cholerae strains.

BACKGROUND Intestinal colonization of humans with virulent Vibrio cholerae stimulates substantial, lasting immunity against reinfection. The purpose of this study was to evaluate the colonizing capability of various Vibrio cholerae strains which are promising candidates to oral vaccine. METHODS Infant mouse model modification was used. In order to standardize the method, several parameters were tested, such as culture medium and optimal time of incubation and appropriate number of cells to be inoculated. The following were tested: Vibrio cholerae strain 81, 413, and 251A, which were obtained at the Molecular Biology Department of the National Center for Scientific Research, Havana, Cuba. Their virulence cassettes which code for the main virulence factors were deleted. RESULTS Good variance coefficient (VC) was obtained in repeated experiments. The colonizing properties of attenuated Vibrio cholerae strains evaluated by this method correlated well with those observed for parental strains. CONCLUSIONS Genetically attenuated Vibrio cholera strains have the same intestinal colonization level as their parental strains in the infant mouse model; thus, genetic manipulation does not affect genes that encode for the synthesis of colonization factors.
SER Analysis of Scheduled TAS With MRC in the Presence of Non-Identical Channel Estimation Errors

In this letter, we present a performance analysis of scheduled transmit antenna selection with maximal ratio combining (TAS-MRC) in the presence of non-identical channel estimation errors. This letter derives the probability density function (PDF) of the instantaneous effective signal-to-noise ratio for the scheduled TAS-MRC over Rayleigh fading channels with non-identical channel estimation errors. Using this PDF, we derive exact closed-form expressions for the scheduled TAS-MRC symbol error rate in the presence of non-identical channel estimation errors. The analysis results show that the order of diversity of scheduled TAS-MRC is improved in terms of transmit spatial diversity and multiuser diversity, whereas the received diversity is diminished by non-identical channel estimation errors, regardless of the modulation type.
Patients not P values

1 Novara G, Chapple CR, Montorsi F. A pooled analysis of individual patient data from registrational trials of silodosin in the treatment of non-neurogenic male lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH). BJU Int 2014; 114: 427–33 2 Novara G, Chapple CR, Montorsi F. Individual patient data from registrational trials of silodosin in the treatment of non-neurogenic male lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH): subgroup analyses of efficacy and safety data. BJU Int 2015; 115: 802–4 3 Chapple CR, Montorsi F, Tammela TL et al. Silodosin therapy for lower urinary tract symptoms in men with suspected benign prostatic hyperplasia: results of an international, randomized, double-blind, placeboand active-controlled clinical trial performed in Europe. Eur Urol 2011; 59: 342–52 4 Sturch P, Woo HH, McNicholas T, Muir G. Ejaculatory dysfunction after treatment for lower urinary tract symptoms: retrograde ejaculation or retrograde thinking? BJU Int 2014. doi: 10.1111/bju.12868 5 Montorsi F. Profile of Silodosin. Eur Urol Suppl 2010; 9: 491–5 6 Novara G, Tubaro A, Sanseverino R et al. Systematic review and meta-analysis of randomized controlled trials evaluating silodosin in the treatment of non-neurogenic male lower urinary tract symptoms suggestive of benign prostatic enlargement. World J Urol 2013; 31: 997–1008
Pyrolysis- GC/MS Analysis of Biomedical Constituents in the Acetone Extractive of Osmanthus Fragrans Leaf by Ultrasonic Extraction

As the noble gardening tree growing specifically in China, Osmanthus fragrans is widely used to produce high-grade essence, special drugs and aromatic tea form its flowers. However, O. fragrans leaves are still underutilized and hence wasted. Therefore, in order to better utilize O. fragrans leaves and hence to expand its utility values and industrial scopes, we attempted to analyze the bioactive components, especially biomedical constituents from O. fragrans leaf by the way of Py-GC/MS (Pyrolysisgas chromatograph/ mass spectrometer). After acetone extraction on O. fragrans fresh leaf by ultrasonic extraction for 5 h at 90°C, and with the removal of solvent, the extractive was pyrolyzed in 590°C He atmosphere, then the pyrolysis product was analyzed by online linked GC/MS. Relative content of each component was determined by area normalization, and 64 compounds representing 97.85% of the acetone ultrasonic extractive were identified from 65 peaks (Figure 1). The main constituents were as: friedelan-3-one (38.87%), lup-20(29)-en-3-one (12.46%), Stigmasterol,22,23dihydro(6.23%), Urs-12-ene (5.45%), benzoic acid,4-hydroxy-3methoxy(2.08%), stigmasterol (1.96%), cyclotetracosane (1.92%), acetone (1.59%), beta-amyrin (1.57%), benzoic acid,4hydroxy(1.32%), 1,6-anhydro-. beta. -D-glucopyranose (1.32%), toluene,3-(2-cyano-2-phenylethenyl-) (1.22%), taraxasterol (1.20%), 1,2-propanediamine (1.07%), hexadecanoic acid (1.00%), ergosta-4,6,22-trien-3.alpha. -ol (1.00%), 1,2-benzenediol (0.91%), vitamin E (0.90%), campesterol (0.89%), etc. The results of function analyses suggested that the pyrolysis product from the acetone ultrasonic extractive of O. fragrans leaf is abundant in materials of noble natural medicines, and also contains constituents which can be developed into top valueadded materials of cosmetics, biofuel and industrial. This is the first report here that showed underutilized leaf of O. fragrans contains abundant biomedical constituents and can be developed into top value-added products. Keywords-component; Osmanthus fragrans leaf; biomedical constituents; PyrolysisGC/MS (Pyrolysisgas chromatograph/ mass spectrometer); top value added; ultrasonic extraction
Properties of adenosine deaminase from Candida albicans

Adenosine deaminase (ADA; adenosine aminohydrolase, E.C. 3.5.4.4), a purine catabolic enzyme, was studied in Candida albicans, an opportunistic yeast that causes diseases ranging from superficial infections to the deep systemic disease, candidiasis, in immunosuppressed humans. The fungus was grown as a yeast form in Lee's synthetic medium, pH 4.5, at room temperature for various growth periods. Adenosine deaminase (ADA) activity was determined from the cell free extract by measuring the change in absorbance 265 nm resulting from the deamination of adenosine. In yeast form, maximum growth and ADA activity were found at 72 and 24 hours, respectively, whereas in the mycelial form both the growth and ADA activity were maximum after 48 hours. Among the three media tested, tryptic soy broth supported maximum growth and enzyme production, compared to Lee synthetic medium or Sabouraud dextrose broth. The enzyme was active over the pH range 4–8 and the optimum temperature for ADA activity was found to be 37 °C.
On the Impact of Diversity Combining Schemes to the Performance of RAKE Receivers over GWSSUS Fading Channels

Signal-to-interference ratio (SIR) experienced by users is the major quality and capacity indicator of CDMA systems. In this paper, we analyze the impact of diversity combining schemes - maximal-ratio combining (MRC) and equal-gain combining (EGC) - on the SIRs achievable with diversity-reception RAKE receivers over GWSSUS time-variant fading uplink DS-CDMA channels based on finite-dimensional generalized random spreading performance evaluation methodology. Through the results of random matrix theory on the non-asymptotic eigenvalue distributions of finite-size random matrices, SIR statistics with linear RAKE multiuser receivers with MRC and EGC are derived in terms of the key system parameters. It turns out that MRC that is much complex than EGC in terms of channel estimation and computational complexity slightly outperforms EGC at low diversity orders and low channel specularity; however the performance of EGC converges to that with MRC as the diversity order Drarr infin and the channel specularity tends to 1 as well as at low SNRs
Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis

The pathogenesis of neuronal cell death as a consequence of mutations in copper/zinc superoxide dismutase (SOD1) associated with familial amyotrophic lateral sclerosis may involve oxidative damage and mitochondrial dysfunction. We examined whether crossing transgenic mice with the G93A SOD1 mutation with transgenic mice with a partial depletion of manganese superoxide dismutase (SOD2) would affect the disease phenotype. Compared with G93A mice alone, the mice with partial deficiency of SOD2 and the G93A SOD1 mutation showed a significant decrease in survival and an exacerbation of motor deficits detected by rotorod testing. There was a significant exacerbation of loss of motor neurons and substantia nigra dopaminergic neurons in the G93A mice with a partial deficiency of SOD2 compared with G93A mice at 110 days. Microvesiculation of large motor neurons was more prominent in the G93A mice with a partial deficiency of SOD2 compared with G93A mice at 90 days. These findings provide further evidence that both oxidative damage and mitochondrial dysfunction may play a role in the pathogenesis of motor neuron death associated with mutations in SOD1. Ann Neurol 2000;47:447–455.
Genetic Variation Analysis of Nsp2 and GP5 Amino Acids of Porcine Reproductive and Respiratory Syndrome Virus in Clinical in Central China

In order to disclose the genetic variation of PRRSV,65 materials from some areas were identified during the period from 2013 to 2014.Viruses were isolated from the suspected PRRS samples.Four isolates were isolated and identified by RT-PCR and IFA.Partial Nsp2 amino acid sequences of the isolates were obtained by sequencing,and comparison analysis showed that all of the isolates were variant strains.Then we found a discontinuous deletion of 30 amino acids in Nsp2.It shared the same feature with JXA1 and TJ.Besides,we sequenced and analyzed the GP5 amino acids of 23 currently epidemic strains with some typical strains published online earlier,the results showed that all strains were American strain,21 of which had high homology with highly pathogenic variant strains(JXA1,TJ and HUN4). Moreover,further analysis of the GP5 protein suggested that these strains exhibited variations in the primary neutralizing epitope and N-linked glycosylation sites.The other two strains had the same genetic features with RespPRRSV MLV.The results showed that the highly pathogenic PRRSV was still the dominant strain and GP5 amino acid mutations were frequently,there were some genetic differences between PRRSV in different regions.
Research on the Measurement of IT-Business Alignment

We provide a review of the measurement literature in IT-business alignment, addressing questions such as: What is IT-business alignment? How to measure and assess IT-business alignment? What benefits can reasonably be expected from IT alignment? In this article, the different fit models and capability maturity model perspectives on the measurement of IT alignment are analyzed. We propose integrating views and suggest future directions, the study is intended to be useful to faculty and practitioners seeking to assess the 'state-of-play'.
Urokinase perfusion prevents intrahepatic ischemic-type biliary lesion in donor livers.

AIM To evaluate whether urokinase perfusion of non-heart-beating cadaveric donor livers reduces the incidence of intrahepatic ischemic-type biliary lesions (IITBLs). METHODS A prospective study was conducted to investigate potential microthrombosis in biliary microcirculation when non-heart-beating cadaveric livers were under warm or cold ischemic conditions. The experimental group included 140 patients who underwent liver transplantation during the period of January 2006 to December 2007, and survived for more than 1 year. The control group included 220 patients who received liver transplantation between July 1999 and December 2005 and survived for more than 1 year. In the experimental group, the arterial system of the donor liver was perfused twice with urokinase during cold perfusion and after trimming of the donor liver. The incidence of IITBLs was compared between the two groups. RESULTS In the control group, the incidence of IITBLs was 5.9% (13/220 cases) after 3-11 mo of transplantation. In the experimental group, two recipients (1.4%) developed IITBLs at 3 and 6 mo after transplantation, respectively. The difference in the incidence between the two groups was statistically significant (P < 0.05). CONCLUSION Double perfusion of cadaveric livers from non-heart-beating donors with urokinase may reduce the incidence of IITBLs.
Megakaryocyte Features and bcr/abl Translocation in Chronic Myeloid Leukemia following Imatinib Mesylate (STI571) Therapy—a Fluorescence in-situ Hybridization Study

Following therapy with imatinib (STI571) hematologic and cytogenetic response in chronic myeloid leukemia (CML) is associated with conspicuous alterations of bone marrow (BM) morphology. Besides reduction of cellularity and fibrosis, small megakaryocytes characteristic for this disorder were replaced by large, normally appearing cells of this lineage. However, it is not known whether and to which extent these changes are accompanied by a loss of the bcr/abl translocation. Therefore an immunohistochemical (CD61) and fluorescence in-situ hybridization (FISH) study was performed on sequential BM biopsies in 5 patients with CML receiving STI571 without any pretreatment. Morphometric analysis revealed that the prevalent population of 47% micromegakaryocytes (size < or = 150 microm2) was significantly reduced (15%) during therapy and that a conspicuous shift to medium-sized and large megakaryocytes occurred. According to FISH analysis in the initial BM biopsy sections 71% of all myeloid cells exhibited the bcr/abl gene and concerning megakaryopoiesis about 65% of the prominent micromegakaryocytes displayed positive signals. After treatment this peculiar cell population decreased significantly while the emerging large megakaryocytes (52%) totally lacked a bcr/abl labeling. Because cytogenetic response and reduction of micromegakaryocytes seem to be linked, this feature may be useful to monitor therapeutic efficacy by evaluating BM morphology.
Predictors of course in obsessive–compulsive disorder: logistic regression versus Cox regression for recurrent events

Objective: Two methods for predicting remissions in obsessive–compulsive disorder (OCD) treatment are evaluated. Y‐BOCS measurements of 88 patients with a primary OCD (DSM‐III‐R) diagnosis were performed over a 16‐week treatment period, and during three follow‐ups.
An Adaptive Heterogeneous Multiple Ant Colonies Algorithm

This paper proposes an Adaptive Heterogeneous Multiple Ant Colonies System (AHMACS) Algorithm to solve the Traveling Salesman Problem (TSP). In this algorithm, heterogeneous multiple ant colonies with different pheromone updating mechanism had different searching traits. To leverage this feature, we designed a set of adaptive rules to facilitate the collaboration between these colonies. An evolution coefficient was defined to adaptively determine ant sub-colonies ' information exchange partners and information exchange strategies. This approach can balance the diversity and convergence of solutions generated by different ant colonies. We used a set of TSP experiments to show that this algorithm can generate solutions with better quality and faster speed.
Maneuvering through Hostile Environments: How Firms Leverage Product and Process Innovativeness

Is focusing on innovativeness the appropriate organizational response in hostile environments? This study addresses four distinct forms of hostile environments: market decline, restrictiveness, competition, and resource scarcity. The research draws on contingency theory to explain how these forms of hostility affect product innovativeness, process innovativeness, and firm performance. While the extant literature has investigated the effects of hostile environments on performance, little has been done to distinguish between different forms of hostility and, in turn, their potential effect on product and process innovativeness. We argue that investments in product and process innovativeness are either fostered or hindered, contingent on the form of hostile pressures from the external operating environment. These firm responses should in turn suppress the negative effects of hostility on performance. A survey using newly developed measurement scales for hostile environments was used to collect data from 148 small and medium-sized manufacturing plants. The results provide evidence that generally supports our hypotheses. More specifically, the direct effects of the four forms of hostile environments impact product and process innovativeness differently. Likewise, the suppression and consistent mediation effects of product and process innovativeness differ depending upon the type of hostile environment, suggesting that manufacturers consider applying these capabilities contingent upon the type of hostile climate they face. Therefore, to understand how firms leverage product and process innovativeness, hostile environments are best differentiated into categories rather than being aggregated. [web URL: http://onlinelibrary.wiley. com/doi/10.1111/deci.12196/full]
Fuzzy-Approximator-Based Adaptive Controller Design for Ship Course-Keeping Steering in Strict-Feedback Forms

Along with increasing marine transportation and logistics, the ship autopilot has become much important not only to lower the seaman's operating intensions, but also to reduce the seaman's deployment. It is still a challenge to design ship course-keeping controller because of ship's uncertain dynamics and time-varying environmental disturbance. This study focuses on backstepping adaptive course-keeping controller design for ship autopilot. Takagi-Sugeno (T-S) fuzzy approximator can formulate ship motion's uncertainties. Therefore, the proposed controller has no need of a priori knowledge about ship's system dynamics. Command filter can bypass the iterative differential manipulations in conventional ship course adaptive backstepping controller. The design can guarantee the ultimate uniform boundedness of the signals in closed-loop system. Finally, simulation study verifies the efficiency of the ship course-keeping design.
Road signs recognition using a dynamic pixel aggregation technique in the HSV color space

We present a system for the whole road sign detection and recognition task. Road sign regions are detected and extracted from real-world scenes on the basis of their color and shape features. Color segmentation is performed introducing a dynamic threshold in the pixel aggregation process on the HSV color space. The dynamic threshold allows the reduction of hue instability in real scenes depending on external brightness variation. Experimental results, using real road images in different environment conditions, are also reported.
Statistical Physics of Sparse and Dense Models in Optimization and Inference

Une donnee peut avoir diverses formes et peut provenir d'un large panel d'applications. Habituellement, une donnee possede beaucoup de bruit et peut etre soumise aux effets du hasard. Les recents progres en apprentissage automatique ont relance les recherches theoriques sur les limites des differentes methodes probabilistes de traitement du signal. Dans cette these, nous nous interessons aux questions suivantes : quelle est la meilleure performance possible atteignable ? Et comment peut-elle etre atteinte, i.e., quelle est la strategie algorithmique optimale ? La reponse depend de la forme des donnees. Les sujets traites dans cette these peuvent tous etre representes par des modeles graphiques. Les proprietes des donnees determinent la structure intrinseque du modele graphique correspondant. Les structures considerees ici sont soit eparses, soit denses. Les questions precedentes peuvent etre etudiees dans un cadre probabiliste, qui permet d'apporter des reponses typiques. Un tel cadre est naturel en physique statistique et cree une analogie formelle avec la physique des systemes desordonnes. En retour, cela permet l'utilisation d'outils specifiques a ce domaine et de resoudre des problemes de satisfaction de contraintes et d'inference statistique. La problematique de performance optimale est directement reliee a la structure des extrema de la fonction d'energie libre macroscopique, tandis que les aspects algorithmiques proviennent eux de la minimisation de la fonction d'energie libre microscopique (c'est-a-dire, dans la forme de Bethe). Cette these est divisee en quatre parties. Premierement, nous aborderons par une approche de physique statistique le probleme de la coloration de graphes aleatoires et mettrons en evidence un certain nombre de caracteristiques. Dans un second temps, nous calculerons une nouvelle limite superieure de la taille de l'ensemble contagieux. Troisiemement, nous calculerons le diagramme de phase du modele de Dawid et Skene dans la region dense en modelisant le probleme par une factorisation matricielle de petit rang. Enfin, nous calculerons l'erreur optimale de Bayes pour une classe restreinte de l'estimation matricielle de rang eleve.