Miracle-dz/UniFAR-FTUs huggingface dataset:
Extramedullary Relapse in RARA Rearrangement-negative Acute Promyelocytic Leukemia Successfully Treated in Combination With Chemotherapy, Local Radiotherapy, and Cord Blood Transplantation

RARA rearrangement-negative acute promyelocytic leukemia (APL) is uncommon, and its extramedullary relapse is extremely rare. We report a 5-year-old girl with RARA rearrangement-negative APL, which recurred solely at the external auditory canal and mastoid air cells. She was successfully treated with chemotherapy, local radiotherapy, and unrelated cord blood transplantation. She has maintained complete remission for 24 months after transplantation. The clinical features and our therapeutic strategy in this patient will provide valuable information for extramedullary relapse of RARA rearrangement-negative APL.
Isolation by high-performance liquid chromatography and partial characterization of a 57,000-dalton herpes simplex virus type 1 polypeptide

A Nonidet P-40 extract of HSV-1-purified virions was fractionated by reversed-phase high-performance liquid chromatography (RP-HPLC). The first peak fraction eluted at 25% organic solvent. Polyacrylamide gel electrophoresis showed that it contained a 57,000-dalton polypeptide. The polypeptide was characterized by determination of the amino acid composition and the N-terminal amino acid sequence. Adsorption of the detergent extract before RP-HPLC showed that the polypeptide reacted with monoclonal antibodies LP1 directed against herpes simplex virus polypeptide VP-16.
Donepezil for treatment of cognitive dysfunction in children with Down syndrome aged 10–17

The objective of this 10‐week, randomized, double‐blind, placebo‐controlled multicenter study was to assess the efficacy and safety of donepezil for the treatment of cognitive dysfunction exhibited by children with Down syndrome (DS). Intervention comprised donepezil (2.5–10 mg/day) in children (aged 10–17 years) with DS of mild‐to‐moderate severity. The primary measures were the Vineland‐II Adaptive Behavior Scales (VABS‐II) Parent/Caregiver Rating Form (PCRF) the sum of nine subdomain standardized scores and standard safety measures. Secondary measures included the VABS‐II/PCRF scores on the following domains and their respective individual subdomains: Communication (receptive, expressive, and written); Daily Living Skills (personal, domestic, and community); Socialization (interpersonal relationships, play and leisure time, and coping skills), and scores on the Test of Verbal Expression and Reasoning, a subject‐performance‐based measure of expressive language. At baseline, 129 participants were assigned treatment with donepezil or placebo. During the double‐blind phase, VABS II/PCRF sum of the nine subdomain standardized scores, called v‐scores, improved significantly from baseline in both groups (P < 0.0001), with no significant between‐group differences. This trial failed to demonstrate any benefit for donepezil versus placebo in children and adolescents with DS, although donepezil appeared to be well tolerated. © 2010 Wiley‐Liss, Inc.
A sustainable quality assessment model for the information delivery in E-learning systems

Purpose E-learning is becoming mainstream due to its accessibility, state-of-the-art learning, training ease and cost effectiveness. However, the poor quality of e-learning systems is one of the major causes of several failures reported. Moreover, this arena lacks well-defined quality assessment measures. Hence, it is quite difficult to measure the overall quality of an e-learning system effectively. Design/methodology/approach A pragmatic mixed-model philosophy was adopted for this study. A systematic literature review was performed to identify existing e-learning quality models and frameworks. Semi-structured interviews were conducted with e-learning experts following empirical investigations to identify the crucial quality characteristics of e-learning systems. Various statistical tests like Principal Component Analysis, Logistic Regression, Chi-square and Analysis of Means were applied to analyze the empirical data. These led to an adequate set of quality indicators that can be used by higher educatio.
J OURNAL OF I NFORMATION T ECHNOLOGY T HEORY AND A PPLICATION

: Business process management (BPM) has developed as a research field primarily situated in the computer and information systems sciences. Recently, van der Aalst (2013) analyzed the results of these research efforts and identified a set of research topics in the form of a series of BPM research use cases. Those BPM research use cases emphasize technological and computational challenges and solutions. Ideally, however, BPM research should also address managerial and organizational challenges that the existing technically oriented research use cases do not fully reflect. We propose expanding the scope and impact of BPM research by drawing on work system theory (WST) to identify new BPM research use cases and directions. After comparing a WST perspective on basic BPM topics with the technically oriented BPM perspective expressed in van der Aalst (2013), we present new research topics that extend the technically oriented BPM research use cases in van der Aalst (2013). We also present new research directions that go beyond those use cases. Taken together, the extensions of the existing research use cases and the new use cases lead to a more balanced BPM research agenda that more fully blends technical and managerial challenges.
Anesthetic management of the patient with a bronchogenic cyst: a review of 24 cases.

ronchogenic cysts are fluidor air-filled cysts arising from the primitive foregut, lined with respiratory epithelium, and usually located adjacent to the tracheobronchial tree or within pulmonary parenchyma (1). They comprised 7.5% of all mediastinal masses in one large pediatric surgical study and literature review (2). The cyst may be an asymptomatic finding, a focus of recurrent pulmonary infection, or a cause of life-threatening airway obstruction (3-8). Patients may present a diagnostic dilemma because of these variable symptoms and the wide range in age at presentation (1,6,9-11). The anesthetic management of such patients is not well-defined. Theoretical concerns have been voiced about the possibility of tension pneumothorax with positive pressure ventilation and/or increasing cyst size with the use of nitrous oxide (12,13). A 13-yr review of 24 cases at one institution was undertaken to better delineate the perioperative outcome of these patients.
Clinicopathologic features and endoscopic treatment of superficially spreading colorectal neoplasms larger than 20 mm.

BACKGROUND A colorectal neoplasm that spreads superficially over the mucosa is known as a laterally spreading tumor. The clinicopathologic features of these large lesions and the efficacy and safety of endoscopic mucosal resection (EMR) were studied retrospectively. METHODS Surgically or endoscopically resected laterally spreading tumors larger than 20 mm in diameter were studied. Lesions were divided into 2 macroscopic subtypes: F-type, composed of superficially spreading lesions with a flat and smooth surface, and G-type, composed of superficially spreading aggregates of nodules that form relatively flat, broad-based lesions with granulonodular and uneven surfaces. RESULTS Thirty-three lesions were of the F-type and 87 the G-type. G-type (mean +/- SD, 35.3 +/- 11.4 mm) lesions were significantly larger (p < 0.01) than F-type (26.0 +/- 7.2 mm) lesions. F-type lesions had a significantly higher frequency of invasive cancer (27.2%) than G-types (10.3%)(p < 0.05). Of the 120 lesions, 81 (67.5%) were resected endoscopically. Patients with 78 of these lesions were followed postoperatively for 60.8 +/- 20.1 months. The rate of local recurrence of endoscopically treated tumors as determined at colonoscopy was 7.4% (6/78). These lesions were completely resected endoscopically. Distant metastases were not detected. Thirteen (16.0%) patients had local bleeding after EMR that was stopped endoscopically. Microperforation of the colonic wall as a result of EMR was diagnosed in 1 (1.2%) of 81 cases. CONCLUSIONS Laterally spreading tumors larger than 20 mm, especially those of the G-type, have a low rate of invasion despite their relatively large size. The F-type lesion has a higher malignant potential than the G-type. EMR is an effective and safe treatment for the large laterally spreading tumor.
Toward a standardized common M2M service layer platform: Introduction to oneM2M

At present, most M2M solutions in different industries use proprietary systems that often comprise all layers, from physical to application, to provide their specialized M2M services to customers. These proprietary systems make it difficult to extend systems to support new services, integrate new data, and interoperate with other M2M systems. This issue motivated various standard organizations to establish a new partnership project, the "oneM2M Global Initiative," to standardize a common M2M service layer platform for globally applicable and access-independent M2M services. This article presents a snapshot of the latest progress in oneM2M standardization such as the requirements, agreed architecture, candidate protocols, security aspects, and device management and abstraction technologies.
Alcohol and sexual risk behaviors as mediators of the sexual victimization-revictimization relationship.

OBJECTIVE Women who experience sexual victimization, whether in childhood, adolescence, or adulthood, are at elevated risk of sexual revictimization. The mechanism responsible for this robust association is unclear, however. The present study proposed and tested a prospective, mediated model that posited that the association between adolescent and college victimization is mediated via 2 types of risk exposure in the first semester of college: alcohol-related and sexual risk behaviors. METHOD Female adolescents (N = 469) were recruited from the community at the time of high school graduation. They completed baseline assessments as well as follow-ups at the end of the first and second semesters of college. RESULTS Consistent with hypotheses, adolescent sexual victimization was associated indirectly, via high school risk behaviors, with increased first-semester college risk behaviors (i.e., sexual partners, hookups, heavy episodic drinking, and heavy drinking contexts), which were, in turn, strongly predictive of sexual victimization experiences in the first year of college. College risk behaviors partially mediated the significant association between adolescent and first-year college victimization; however, even women without prior victimization faced elevated risk of college victimization with higher levels of college risk behaviors. CONCLUSIONS Women who have experienced adolescent sexual victimization engage in higher levels of risk taking in college, thereby increasing vulnerability to college victimization. Intervention to reduce these primarily alcohol-related risk-taking behaviors may reduce vulnerability to college sexual victimization.
An18-pulse AC-DC converter-fed 27-level inverter based vector controlled induction motor drive

This paper proposes a method to enhance the power quality of the medium voltage multilevel inverter based induction motor drive system. An 18-pulse AC-DC converter is used to feed a 27-level inverter based vector controlled induction motor drive (VCIMD). Using this configuration, the input supply current distortion decreases to meet the demand of an IEEE-519 standard. The distortion in the 27-level inverter output voltage and its switch cost are decreased impressively with an increase in the number of AC-output voltage levels. As the steps of output voltage are increased, it is switched at low switching frequency. The proposed drive system is examined in the all possible operating conditions of an induction motor. The proposed 18-pulse AC-DC converter fed 27-level inverter for VCIMD is modelled and its performance is simulated in Simulink/MATLAB environment to demonstrate its effectiveness for the medium and large rating applications.
Control of Viremia and Prevention of Simian-Human Immunodeficiency Virus-Induced Disease in Rhesus Macaques Immunized with Recombinant Vaccinia Viruses plus Inactivated Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Particles

ABSTRACT An effective vaccine against the human immunodeficiency virus type 1 (HIV-1) will very likely have to elicit both cellular and humoral immune responses to control HIV-1 strains of diverse geographic and genetic origins. We have utilized a pathogenic chimeric simian-human immunodeficiency virus (SHIV) rhesus macaque animal model system to evaluate the protective efficacy of a vaccine regimen that uses recombinant vaccinia viruses expressing simian immunodeficiency virus (SIV) and HIV-1 structural proteins in combination with intact inactivated SIV and HIV-1 particles. Following virus challenge, control animals experienced a rapid and complete loss of CD4+ T cells, sustained high viral loads, and developed clinical disease by 17 to 21 weeks. Although all of the vaccinated monkeys became infected, they displayed reduced postpeak viremia, had no significant loss of CD4+ T cells, and have remained healthy for more than 15 months postinfection. CD8+ T-cell and neutralizing antibody responses in vaccinated animals following challenge were demonstrable. Despite the control of disease, virus was readily isolated from the circulating peripheral blood mononuclear cells of all vaccinees at 22 weeks postchallenge, indicating that immunologic control was incomplete. Virus recovered from the animal with the lowest postchallenge viremia generated high virus loads and an irreversible loss of CD4+ T-cell loss following its inoculation into a naïve animal. These results indicate that despite the protection from SHIV-induced disease, the vaccinated animals still harbored replication-competent and pathogenic virus.
Bowel Content Shift during Normal Defaecation

Prognosis: The overall mortality rate, estimated as recently as 1961 (Lillington & Bernatz 1961), when the condition is untreated, is about 25% at twelve hours and 70% at twenty-four hours. Up to 1946 (Eliason & Welty 1946) the mortality rate was almost 100%. Thoracotomy with direct suture of the tear has a mortality rate of 10-33% according to different observers, with a low morbidity rate of 13-22 days, whereas in surgical drainage without suture of the tear the mortality rate varies from 46% to 66% with a morbidity lasting from six weeks to one and a half years.
and collective action ' ' We ' re mad as hell and we ' re not going to take it anymore ' ' : Anger self-stereotyping

What can motivate members of disadvantaged groups to take action on behalf of their group? This research assessed a model in which measured perceptions of (study 1) and manipulated information about (study 2) other women’s anger influenced female participants’ group-based anger, their subsequent appraisals of instances of possible discrimination, and finally their collective action tendencies. Consistent with Intergroup Emotions Theory, the results suggested that emotional self-stereotyping is one mechanism by which group members can become motivated to respond to possible discrimination, a process supported by group-based anger-driven appraisals about specific discrimination events.
Prognostic value of ovarian carcinoma grading methods—a method comparison study

The prognostic value of subjective histological and morphometric grading was studied in 75 primary ovarian carcinomas. Histological grading methods recommended by Czernobilsky and by Russell and the morphometric method of Baak and co‐workers were compared in a two‐observer system. The 5‐year survival could be correctly predicted in about two‐thirds of the patients with all three methods. When mitotic counting (volume corrected mitotic index, M/V‐index) was compared with the above grading methods by using a receiver operating characteristic curve) the M/V‐index was generally superior in its prognostic power regardless of the sensitivity/specificity level chosen. The morphometric grading method and the grading method based on the M/V index were also shown to be readily reproducible.
Real Time and Recall Measures of Mobile Phone Use: Some Methodological Concerns and Empirical Applications

This article discusses the development, reliability, and validity of real-time measures of mobile phone use by means of Interactive Voice Response (IVR) technology, in comparison with traditional questionnaire-generated recall measures. The sample consisted of 211 Israeli adult mobile phone subscribers subdivided by gender and by the amount of airtime that they normally use. The measurements were applied to three questions to which the participants responded via IVR following their incoming and outgoing mobile phone calls during a five-day period: the identity of the person with whom they spoke; their location during the call; and the urgency of the call. These data were compared with recall measures obtained earlier from questionnaires. The article discusses the merits of the IVR real-time data versus those obtained from traditional recall questions asking for past or habitual behaviors.
Forms of P in Different Manures and Their Impact on P Runoff and Leaching Losses from Manure Amended Soils: Summary and Implications

Continuous application of manure P at rates that exceed the rate of P removal by crops results in a buildup of soil phosphorus (P). High concentrations of soil P increase the risk of P runoff loss from agricultural land and lead to problems with surface water quality, such as excess algae growth. However, there is little or no information about the effect of applying different sources or types of manure P on the risk of P loss after manure interacts with soil, especially for Prairie soils. Therefore, the objectives of this study were to quantify and compare P losses from soil treated with four sources of liquid swine manure and four sources of solid cattle manure and to relate P runoff and leaching losses to manure P forms and soil test P measurements.
Effects and applicability of rotation gain in CAVE-like environments

In this work, we report on a pilot study we conducted, and on a study design, to examine the effects and applicability of rotation gain in CAVE-like virtual environments. The results of the study will give recommendations for the maximum levels of rotation gain that are reasonable in algorithms for enlarging the virtual field of regard or redirected walking.
Translating GWAS Findings Into Therapies For Depression And Anxiety Disorders: Drug Repositioning Using Gene-Set Analyses Reveals Enrichment Of Psychiatric Drug Classes

Depression and anxiety disorders are the first and sixth leading cause of disability worldwide according to latest reports from the World Health Organization. Despite their high prevalence and the significant disability resulted, there are limited advances in new drug development. On the other hand, the advent of genome-wide association studies (GWAS) has greatly improved our understanding of the genetic basis underlying psychiatric disorders. In this work we employed gene-set analyses of GWAS summary statistics for drug repositioning. We explored five related GWAS datasets, including two on major depressive disorder (MDD-PGC and MDD-CONVERGE, with the latter focusing on severe melancholic depression), one on anxiety disorders, and two on depressive symptoms and neuroticism in the population. We extracted gene-sets associated with each drug from DSigDB and examined their association with each GWAS phenotype. We also performed repositioning analyses on meta-analyzed GWAS data, integrating evidence from all related phenotypes. Importantly, we showed that the repositioning hits are generally enriched for known psychiatric medications or those considered in clinical trials, except for MDD-PGC. Enrichment was seen for antidepressants and anxiolytics but also for antipsychotics. We also revealed new candidates or drug classes for repositioning, some of which were supported by experimental or clinical studies. For example, the top repositioning hit using meta-analyzed p-values was fendiline, which was shown to produce antidepressant-like effects in mouse models by inhibition of acid sphingomyelinase and reducing ceramide levels. Taken together, our findings suggest that human genomic data such as GWAS are useful in guiding drug discoveries for depression and anxiety disorders.
New World Monkeys

New World monkeys are the nonhuman primates of South and Central America. Because almost all of their evolutionary history took place on the island continent of South America without competition from other primates, and most likely in a strictly arboreal setting, the character of their adaptation is unique. Fossils and molecules indicate the major lineages are long enduring, having attained diverse, stable ecological conditions quite early. Today, platyrrhine (wide-nosed) monkeys comprise the most diversified taxonomic group among anthropoids. More primitive anatomically than Old World monkeys or apes, some forms resemble early fossil anthropoids from Egypt and serve well as models for reconstructing their behaviour. Others are more like the specialised apes in their locomotor adaptations, or the modified, folivorous leaf monkeys, whereas some evoke the big-brained, extractive foraging strategies of African apes. Highly varied in their outward appearance as well, the range of social behaviours and mating strategies exhibited by platyrrhines is without equal among the primates.
Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II+ Cells in the Mouse Cornea1

Membrane nanotubes are a recently discovered form of cellular protrusion between two or more cells whose functions include cell communication, environmental sampling, and protein transfer. Although clearly demonstrated in vitro, evidence of the existence of membrane nanotubes in mammalian tissues in vivo has until now been lacking. Confocal microscopy of whole-mount corneas from wild-type, enhanced GFP chimeric mice, and Cx3cr1gfp transgenic mice revealed long (>300 μm) and fine (<0.8 μm diameter) membrane nanotube-like structures on bone marrow-derived MHC class II+ cells in the corneal stroma, some of which formed distinct intercellular bridges between these putative dendritic cells. The frequency of these nanotubes was significantly increased in corneas subjected to trauma and LPS, which suggests that nanotubes have an important role in vivo in cell-cell communication between widely spaced dendritic cells during inflammation. Identification of these novel cellular processes in the mammalian cornea provides the first evidence of membrane nanotubes in vivo.
Isolation and characterization of cDNAs coding for the j3 subunit of the high-affinity receptor for immunoglobulin E

Among receptors that bind the Fc region of immunoglobulins ("Fc receptors"), only the one with high affinity for immunoglobulin E (IgE) is known to consist of more than a single polypeptide. In addition to the IgE-binding a chain, the receptor contains a single 13 chain and two, disulfide-linked, y chains. From a cDNA library of a rat mucosal mast cell tumor, from which we recently cloned cDNAs coding for the a chain, we have now isolated cDNAs coding for the 13 subunit. In vitro transcription-translation ofthe cDNA directed the synthesis of a polypeptide reactive with two distinctive anti-. 8 monoclonal antibodies and whose molecular weight was identical to that of authentic 13 chains. Polyclonal antibodies to . 3 peptides expressed in Escherichia coli reacted with intact receptors and isolated 13 chains. The gene encodes a protein of 243 residues with no leader sequence. A hydropathicity plot suggests that the polypeptide crosses the plasma membrane four times. The epitope recognized by one of the monoclonal antibodies was localized to the NH2 terminus; that by the other was localized to the COOH terminus. Since those antibodies react with membranes and not with intact cells, we suggest that both ends of the 13 subunit are cytoplasmic. RNA transfer blots at high