Miracle-dz/UniFAR-FTUs huggingface dataset:
Remission, Relapse, and Metastasis/Death of Small Hepatocellular Carcinoma Treated with Percutaneous Ethanol Injection

PURPOSEThis study aimed to quantify the full clinical courses characterized by alternating transitions between remission and relapses for small hepatocellular carcinomas treated by percutaneous ethanol injection, and to ascertain the significant predictors for the remission, relapse, and finally to metastasis or death. PATIENTS AND METHODSA three-state Markov process was used to depict full clinical course. A total of 108 patients who underwent nonsurgical therapy as the first choice of treatment were derived from consecutive clinical series of patients registered in one medical center renowned for their use of percutaneous ethanol injection. RESULTSWe found that approximately 57.19% (95% confidence interval [CI]: 39.82%, 74.56%) patients were promptly responsive to initial treatment, whereas 43.81% had delayed response or were resistant to treatment. The rate of relapse (per month) was higher than the rate of remission (19.20% [95% CI: 15.36%, 23.04%] vs. 13.82% [95% CI: 10.72%, 16.93%]). The results from the multivariate analysis indicate that the significant predictors for the full clinical courses are total bilirubin, a-fetoprotein, prothrombin time, globulin, tumor morphology, and alkaline phosphatase. CONCLUSIONSA three-state remission-relapse-death model was proposed to quantify and ascertain the predictors for the multistate disease progression of small hepatocellular carcinomas treated by percutaneous ethanol injection. This model captures the risk of recurrence of tumor as well as the primary endpoint of death.
Domestic Technology Adoption: Comparison of Innovation Adoption Models and Moderators

Domestic technologies, such as assistant robots, have the potential to provide considerable assistance to families in societies with aging populations and increasing labor costs. This study intends 1) to test a series of innovation adoption theories to examine which models may better predict consumer behavioral intention toward the use of domestic technologies and 2) to examine whether lead‐usership and global identity predict intentions. With the floor cleaning robots as target products of the survey and employing a sample of 299 potential consumers in Taiwan, a rapidly aging society, this study finds: 1) the theory of planned behavior (TPB) model accounts for 55% of the variance and better predicts purchase intention than the technology acceptance model and the theory of reasoned action. 2) In the nested TPB model, the effects of usefulness and ease of use on intentions are fully mediated by attitude. 3) When including 2 additional constructs, global identity and lead‐usership, the explanatory power of the extended TPB model rises from 55% to 66%. 4) Lead‐usership moderates the link between attitude and intentions, that is, the stronger the lead‐usership the weaker the effect of attitude on intentions. 5) As lead‐usership and global identity are included in the model, the impact of perceived behavioral control vanishes. 6) Subjective norms moderate (weakening) the effect of attitude on adoption intentions; thus, word of mouth and peer pressure could be powerful communication tools to persuade follower consumers to adopt domestic technologies, such as family robots.
The Metaphor Framing Effect: Metaphorical Reasoning About Text-Based Dilemmas

We investigated the idea that people use metaphor to help make sense of text-based vignettes about everyday dilemmas. First, we found evidence for the metaphor framing hypothesis across 6 experiments in which framing descriptions of dilemmas within various metaphor frames influenced reasoners' decisions about how to resolve the dilemmas. Second, we found evidence for the metaphor processing termination hypothesis across 3 experiments: When a metaphor was not necessary to increase understanding of a dilemma or when it actually increased ambiguity, the metaphor framing effect was attenuated. In particular, when the vignette contained or primed knowledge that could be used to understand the vignette, reasoners were less likely to make decisions consistent with the metaphor, were less likely to rate the metaphor as apt, and were less likely to choose metaphor-consistent responses on a subsequent verbal analogy test. Results are consistent with a constructivist theory of text comprehension, which specifies the conditions under which learners use metaphor to make sense of text vignettes.
Development and test-retest reliability of the Food Photograph Scale for Brazilian adults

study of food practices in Brazil faces important problems because of the nonexistence of properly tested methods and lack of a gold-standard instrument. Furthermore, only one instrument is capable of measuring food choice or knowledge in this specific population. In the present study we sought to develop a rapid assessment tool for food choice, consumption, and knowledge about healthy foods and test the reliability of the assessment tool in young adults as an initial step in the validation process. The scale was composed of 22 photographs of foods that were ready to consume, divided into "healthy" and "unhealthy" groups typically eaten as an afternoon snack in our region. To test the reliability of the instrument, 101 college students (51 males) were asked to select three items in response to three questions: "What would you like to eat as an afternoon snack? " "What do you consider healthy? " "What do you usually eat? " The procedure was repeated in the same subjects 1 month after the first application of the instrument. Results indicated a perfect reliability (κ = 1.0) among men when asked to select what they would like to eat, and perfect reliability was found among men and women when asked to select foods that they considered healthy. Excellent reliability (κ > .75) was found among women and the total sample for foods they would like to eat and among men and women for what they usually eat. As an initial step in validating the instrument, the results suggested that it was properly developed and had reliability in the present context for studies that involve eating behavior.
The effects of adult models and described alternatives on children's choice of behavior management techniques.

GELFAND, DONNA M. ; HARTMANN, DONALD P.; LAMB, ANNE K. ; SrITH, CATHLEEN L. ; MAHAN, MARY ANN; and PAUL, STEPHEN C. The Effects of Adult Models and Described Alternatives on Children's Choice of Behavior Management Techniques. CHILD DEVELOPMENT, 1974, 45, 585-593. 3 experiments investigated the assertion that children trained with punishment and those trained with reward will subsequently use similar measures to train other children under their supervision. The 88 6-8-year-old children individually played a marble-drop game with a rewarding, fining, or unresponsive adult. When each S later trained another child to play the game, he employed techniques strikingly similar to those he had previously experienced himself. Although children were as likely to imitate a punishing model as a rewarding one, nonimitative behaviors consisted mainly either of rewarding or of failing to fine the learner, and Ss' comments to learners were positive and instructive. Verbal descriptions of nondemonstrated training techniques reduced the children's imitation of punishing or unresponsive trainer models. The results were interpreted as providing additional support for arguments against the use of punitive child management techniques.
Torre de Hanoi: datos normativos y desarrollo evolutivo de la planificación

El objetivo de este trabajo ha sido evaluar el desarrollo evolutivo de la planificacion y obtener datos normativos de la prueba de planificacion “Torre de Hanoi” en escolares de Educacion Primaria (EP). Con este proposito se ha seleccionado una muestra de 1.032 alumnos/as escolarizados desde primero hasta sexto curso de EP en la Comunidad Autonoma de Canarias, con edades comprendidas entre los 6 anos y 3 meses y los 12 anos y 4 meses. Se analizo el numero de disenos correctamente realizados por los escolares en los diferentes cursos. Los resultados encontrados ponen de manifiesto la existencia de tres momentos diferenciados en el desarrollo de la planificacion, observandose un rendimiento inferior del alumnado de primer curso frente al resto de los cursos y un rendimiento mas similar entre, por un lado, el alumnado de segundo, tercero y cuarto, y, por otro lado, entre el de quinto y sexto curso. Asimismo, se observa una mejora progresiva en la planificacion -en funcion de la edad. Por ultimo, se presenta el baremo para EP de la prueba “Torre de Hanoi”.
Occupational stress, job characteristics, coping, and the mental health of nurses.

OBJECTIVES This study investigated the relationships between job characteristics and coping in predicting levels of anxiety and depression in nurses. The study was based on current theories of occupational stress, and predictors included job demands, social support, decision authority and skill discretion control, effort, over-commitment, rewards, and ways of coping. It was predicted that job demands, extrinsic effort, over-commitment, and negative coping behaviours would be positively associated with depression and anxiety, and social support, rewards, decision authority, skill discretion control, and positive coping would be negatively associated with depression and anxiety. METHODS Participants were 870 nurses, who responded to a bulk mail sent randomly to 4,000 nurses from the south of England. RESULTS The results showed that job demands, extrinsic effort, and over-commitment were associated with higher levels of anxiety and depression. Social support, rewards, and skill discretion were negatively associated with mental health problems. Few interactions were found between the variables. Coping behaviours significantly added to the explanation of variance in anxiety and depression outcomes, over and above the use of demand-control-support, and effort-reward factors alone. CONCLUSION The results from the study demonstrated the importance of coping factors in work-stress research, in accordance with the multi-factorial premise of transactional stress models. It is argued that multi-factor research is needed to help develop effective organizational interventions.
K-means++ for mixtures of von Mises-Fisher Distributions

Von Mises-Fisher (vMF) Distribution is one of the most commonly used distributions for fitting directional data. Mixtures of vMF (MovMF) distributions have been used successfully in many applications. One of the important problems in mixture models is the problem of local minima of the objective function. Therefore, approaches to avoid local minima problem is essential in improving the performance. Recently, an algorithm called k-means++ was introduced in the literature and used successfully for finding initial parameters for mixtures of Gaussian (MoG) distributions. In this paper, we adopt this algorithm for finding good initializations for MovMF distributions. We show that MovMF distribution will lead to the same cost function as MoGs and therefore similar guarantee as the case of MoG distributions will also hold here. We also demonstrate the performance of the method on some real datasets.
From curiosity to appreciating and re-evaluating cultural diversity in physiotherapy. A self-reflective account of experiences and reactions as a Swedish physiotherapy student in India

As our globalized world entails meetings between health care givers and patients from diverse cultures, cultural factors must be considered in physiotherapy practice. Yet there is insufficient research regarding physiotherapists’ experiences when meeting different cultures. This paper aims to describe my experiences and reactions when meeting a different physiotherapy culture than my own. An autoethnographic study was conducted in India at four different physiotherapy clinical settings during seven weeks. Participant observation and field notes were used to document experiences. The data were analyzed with a qualitative content analysis to find recurring categories and themes. The analysis of field notes resulted in a overreaching category ‘From curiosity to appreciating and re-evaluating cultural diversity in physiotherapy’, divided into three different subcategories and themes: reflecting on hierarchies and the working structure in the context of physiotherapy practice, on the Indian physiotherapy students’ knowledgebase compared with my earlier experiences from Sweden and on the emotions emerging from being a student in the field with minor experience and knowledge in a different context. This reflective process over my experiences has taught me that my own culture is something I can only understand and re-evaluate when I have met a different one, and has helped me to start appreciate and develop further insight of the importance and the complexity of cultural diversity in physiotherapy.
Writing for a Living

This article seeks to explore the influence of the knowledge economy on the status of writing and literacy. It inquires into what happens to writers and their writing when texts serve as the chief commercial products of an organization—when such high-stakes factors as corporate reputation, client base, licensing, competitive advantage, growth, and profit rely on what and how people write. Drawing on in-depth interviews with 12 individuals employed in writing-intensive positions, it examines the organization of workplaces for the production of texts, the work of writers as mediational means within the workplace, the growing presence of regulatory controls on the production of writing, and the ways that demands for innovation and change affect writers and their writing. This is an exploratory installment in a larger project that seeks to situate the rise of mass writing in the United States, since about 1960, not only as an economic phenomenon but as a new development in the history of literacy with serious cultural, political, social, and personal implications.
Caspase-mediated Cleavage of RNA-binding Protein HuR Regulates c-Myc Protein Expression after Hypoxic Stress*

Altered expression of RNA-binding proteins modulates gene expression in association with mRNAs encoding many proto-oncogenes, cytokines, chemokines, and proinflammatory factors. Hu antigen R (HuR), a ubiquitously expressed protein, controls a range of cellular functions such as tumor progression, apoptosis, invasion, and metastasis by stabilizing the AU-rich element located at the 3′-untranslated region (UTR) of target mRNAs. Although significant progress has been made in understanding HuR regulation in gene expression, little is known about how HuR undergoes post-translational modifications and recruits target mRNAs during hypoxic stress. Here, we report that during CoCl2-induced hypoxic stress, HuR is significantly overexpressed and undergoes caspase-dependent cleavage in head and neck squamous cell carcinoma cells. Unexpectedly, the HuR-cleavage product 1 (HuR-CP1) was found to strongly associate with the 3′-UTR of c-myc mRNA and block mRNA translation. The binding efficiency of HuR to the 3′-UTR of c-myc mRNA was confirmed using ribonucleoprotein immunoprecipitation and site-directed mutagenesis at the AU-rich element sequences of the c-myc mRNA. Overexpression of a non-cleavable isoform, HuR-D226A, revealed a potent dominant-negative effect, repressing cleavage of endogenous HuR and promoting cell viability. Surprisingly, under hypoxia, siRNA knockdown of HuR elevated c-Myc protein expression. These findings suggest an important role for HuR in hypoxia, and we may have revealed a novel post-transcriptional mechanism that controls c-Myc expression in oral cancer progression.
The pancreatic &bgr;-cell transcriptome and integrated-omics

Purpose of review&bgr; Cells represent one of many cell types in heterogeneous pancreatic islets and play the central role in maintaining glucose homeostasis, such that disrupting &bgr;-cell function leads to diabetes. This review summarizes the methods for isolating and characterizing &bgr; cells, and describes integrated ‘omics’ approaches used to define the &bgr; cell by its transcriptome and proteome. Recent findingsRNA sequencing and mass spectrometry-based protein identification have now identified RNA and protein profiles for mouse and human pancreatic islets and &bgr; cells, and for &bgr;-cell lines. Recent publications have outlined these profiles and, more importantly, have begun to assign the presence or absence of specific genes and regulatory molecules to &bgr;-cell function and dysfunction. Overall, researchers have focused on understanding the pathophysiology of diabetes by connecting genome, transcriptome, proteome, and regulatory RNA profiles with findings from genome-wide association studies. SummaryStudies employing these relatively new techniques promise to identify specific genes or regulatory RNAs with altered expression as &bgr;-cell function begins to deteriorate in the spiral toward the development of diabetes. The ultimate goal is to identify the potential therapeutic targets to prevent &bgr;-cell dysfunction and thereby better treat the individual with diabetes. Video abstracthttp://links.lww. com/COE/A5.
Parent–offspring similarity in personality and adolescents' problem behaviour

Similarity in personality between adolescents and their parents may have considerable implications for adolescent well‐being. We studied how the similarity in personality between 288 adolescents and their parents is linked to adolescent problem behaviour, and whether this link is mediated by warmth and control in the parent–child relationship and moderated by the personality type of the adolescent. Similarity in personality between adolescents and their parents was negatively related to internalizing and externalizing problem behaviour, both concurrently and over time. This relation was not mediated by the parent–child relationship. The effects were present for overcontrolled but not for resilient or undercontrolled adolescents. Copyright © 2004 John Wiley & Sons, Ltd.
Leveraging Heterogeneous Data Sources for Relational Semantic Parsing

A number of semantic annotation efforts have produced a variety of annotated corpora, capturing various aspects of semantic knowledge in different formalisms. Due to to the cost of these annotation efforts and the relatively small amount of semantically annotated corpora, we argue it is advantageous to be able to leverage as much annotated data as possible. This work presents a preliminary exploration of the opportunities and challenges of learning semantic parsers from heterogeneous semantic annotation sources. We primarily focus on two semantic resources, FrameNet and PropBank, with the goal of improving frame-semantic parsing. Our analysis of the two data sources highlights the benefits that can be reaped by combining information across them.
Review: Business Research Methods ALAN BRYMAN and EMMA BELL. Oxford: Oxford University Press, 2007. xxxii + 786 pp. £34.99 (pbk). ISBN 9780199284986

its impact on L&D receive a cursory place at the table. In addition to andragogy, which is discussed, the fi eld has much to contribute in other ways to L&D. Most notable for L&D is Cervero and Wilson’s (2006) examination of programme planning in the context of organizational negotiation, power and politics. As an adult educator and L&D practitioner, I have two criteria in selecting a text to use in graduate classes. The fi rst is clear and comprehensive presentation of concepts and theories along with practical, innovative knowledge and examples. The second is its ability to increase and deepen my own knowledge of the fi eld as an academic and practitioner. This book met both criteria on an exemplary level and I recommend its use in the academic and professional arena.
Evaluating Community Partnerships: A Reply to Spitz and Ritter

In the February 2002 issue (JHPPL 27.1), we reported on our largely process evaluation of the Community Care Network (CCN) demonstration program (Shortell et al. 2002). Bruce Spitz and Grant Ritter, in their commentary in that issue, raise a number of objections. They charge that the primary questions of the evaluation were not addressed and point out potential problems raised by the sponsorship of the demonstration and the role of hospitals within the CCN partnership and potential biases in data collection and analysis. Also, they challenge the usefulness of the evaluation findings as a guide for community action. We address each of these points in turn.
Autonomy Infused Teleoperation with Application to BCI Manipulation

Robot teleoperation systems face a common set of challenges including latency, low-dimensional user commands, and asymmetric control inputs. User control with BrainComputer Interfaces (BCIs) exacerbates these problems through especially noisy and erratic low-dimensional motion commands due to the difficulty in decoding neural activity. We introduce a general framework to address these challenges through a combination of computer vision, user intent inference, and arbitration between the human input and autonomous control schemes. Adjustable levels of assistance allow the system to balance the operator’s capabilities and feelings of comfort and control while compensating for a task’s difficulty. We present experimental results demonstrating significant performance improvement using the shared-control assistance framework on adapted rehabilitation benchmarks with two subjects implanted with intracortical brain-computer interfaces controlling a seven degree-of-freedom robotic manipulator as a prosthetic. Our results further indicate that shared assistance mitigates perceived user difficulty and even enables successful performance on previously infeasible tasks. We showcase the extensibility of our architecture with applications to quality-of-life tasks such as opening a door, pouring liquids from containers, and manipulation with novel objects in densely cluttered environments.
Diagnostic Utility of Gene Expression Profiles

Two crucial problems arise from a microarray experiment in which the primary objective is to locate differentially expressed genes for the diagnosis of diseases such as cancer and Alzheimer’s. The first problem is the detection of a subset of genes which provides an optimum discriminatory power between diseased and normal subjects, and the second problem is the statistical estimation of discriminatory power from the optimum subset of genes between two groups of subjects. We develop a new method to select an optimum subset of discriminatory genes by searching over possible linear combinations of gene expression profiles and locating the one which provides the maximum discriminatory power between two sources of RNA as measured by the area under the receiver operating characteristic (ROC) curve. We further provide an estimate to the optimum discriminatory power between the diseased and the healthy subjects over the selected subsets of genes. The proposed stepwise approach takes in account of the gene-to-gene correlations in the estimation of discriminating power as well as the associated variability and allows the number of genes to be selected based on the increment of the discriminating power. Finally, the proposed methodology is applied to a benchmark microarray experiment and compared to the results obtained through existing approaches in the literature.