Miracle-dz/UniFAR-FTUs huggingface dataset:
Essential Transition Metal Homeostasis in Plants This Review Comes from a Themed Issue on Physiology and Metabolism Edited Iron Transport and Use of Iron Copper Regulation of Cu-protein Expression via the Cu-micrornas

The homeostasis of the essential transition metals copper, iron, manganese and zinc requires balanced activities of transporters that mediate import into the cell, distribution to organelles and export from the cell. Transcriptional control is important for the regulation of cellular homeostasis. In the case of Fe and Cu much progress has been made in uncovering the regulatory networks that mediate homeostasis, and key transcription factors have now been described. A master regulator of Cu homeostasis in Arabidopsis thaliana, AtSPL7, is related to the Chlamydomonas master regulator CCR1, suggesting that the key switch is conserved between the two systems even though different sets of targets are regulated in the two systems. Introduction The transition metals copper (Cu), iron (Fe), manganese (Mn) and zinc (Zn) are essential trace elements for plants as cofactors of various proteins [1]. In cells, zinc exists only in its stable Zn 2+ form; by contrast, the redox active metals Cu, Fe and Mn occur in variable redox states in cells and therefore can participate in electron transfer reactions [2]. Owing to their redox activity, Cu, Fe and Mn can catalyze the formation of undesired radicals. The redox potential of Cu and Fe is such that these elements would be especially prone to radical formation in the cells. The Irving-Williams series indicates that the relative binding affinities of the divalent forms of these metals for ligands is Mn < Fe < Zn < Cu. Thus relative to Mn and Fe, the potential for Zn and especially Cu to displace other metals in binding sites of essential proteins is relatively high [2]. To balance need and avoid potential toxic excess, the cellular concentrations of Mn, Zn, Fe and Cu are tightly controlled. For most natural soils, deficiency for Cu, Fe and Zn seems to be a far larger problem than potential excess, and much insight has been gained by comparing the physiology of plants grown under replete versus limiting conditions. Nevertheless, there are several reports in the literature where very high metal ion concentrations have been used in such excess that cellular damage is observed. While such studies may potentially give insight into general (oxidative) stress recovery mechanisms, we think that this type of approach has yielded little useful information on metal ion homeo-stasis, and such approaches are not further considered here. We aim to summarize key findings in the homeo-stasis of essential metal ions with emphasis on the …
Effects of intravenous, low-dose ketamine-diazepam sedation on the results of hematologic, plasma biochemical, and coagulation analyses in cats.

OBJECTIVE To evaluate the effects of an IV, low-dose ketamine-diazepam combination used for short-duration chemical restraint on the results of clinicopathologic testing in cats and to assess its practicality and tolerance. DESIGN Prospective case series. ANIMALS 42 client-owned cats of various breeds, ages, and health status. PROCEDURES Blood samples were obtained just prior to and just after IV injection of ketamine chlorhydrate (10 mg) and diazepam (0.5 mg). A CBC, plasma biochemistry panel, and coagulation profile were performed on each sample (ie, before and after chemical restraint). Practicality of the procedure was assessed, and cats were monitored for immediate and delayed effects. RESULTS Significant changes were observed for most of the analytes tested. However, the magnitude of the observed changes was notably low and likely not of clinical relevance. The chemical-restraint procedure appeared effective, safe, and well tolerated. CONCLUSIONS AND CLINICAL RELEVANCE The IV, low-dose ketamine-diazepam combination used for short-duration chemical restraint in the present study may be suitable to assist physical restraint for blood sampling for assessment of hematologic, serum biochemical, and coagulation parameters in cats.
Generalizing Biomedical Event Extraction

We present a system for extracting biomedical events (detailed descriptions of biomolecular interactions) from research articles. This system was developed for the BioNLP'11 Shared Task and extends our BioNLP'09 Shared Task winning Turku Event Extraction System. It uses support vector machines to first detect event-defining words, followed by detection of their relationships. The theme of the BioNLP'11 Shared Task is generalization, extending event extraction to varied biomedical domains. Our current system successfully predicts events for every domain case introduced in the BioNLP'11 Shared Task, being the only system to participate in all eight tasks and all of their subtasks, with best performance in four tasks.
CPAP promotes timely cilium disassembly to maintain neural progenitor pool

A mutation in the centrosomal‐P4.1‐associated protein (CPAP) causes Seckel syndrome with microcephaly, which is suggested to arise from a decline in neural progenitor cells (NPCs) during development. However, mechanisms of NPCs maintenance remain unclear. Here, we report an unexpected role for the cilium in NPCs maintenance and identify CPAP as a negative regulator of ciliary length independent of its role in centrosome biogenesis. At the onset of cilium disassembly, CPAP provides a scaffold for the cilium disassembly complex (CDC), which includes Nde1, Aurora A, and OFD1, recruited to the ciliary base for timely cilium disassembly. In contrast, mutated CPAP fails to localize at the ciliary base associated with inefficient CDC recruitment, long cilia, retarded cilium disassembly, and delayed cell cycle re‐entry leading to premature differentiation of patient iPS‐derived NPCs. Aberrant CDC function also promotes premature differentiation of NPCs in Seckel iPS‐derived organoids. Thus, our results suggest a role for cilia in microcephaly and its involvement during neurogenesis and brain size control.
Oxidative stress and male infertility: from research bench to clinical practice.

Extensive research in our center at the Cleveland Clinic indicates that the seminal oxidative stress test has diagnostic and prognostic capabilities beyond those of conventional tests of sperm quality or functions. An oxidative stress test can accurately discriminate between fertile and infertile men and identify patients with a clinical diagnosis of male-factor infertility who are likely to initiate a pregnancy if they are followed over a period of time. In addition, the test can help select subgroups of patients with infertility in which oxidative stress is a significant factor, and who may benefit from antioxidant supplementation. Incorporation of such a test into routine andrology laboratory practice may be of particular importance to the future management of male infertility. In recent years, the generation of reactive oxygen species (ROS) in the male reproductive tract has become a real concern because of their potential toxic effects at high levels on sperm quality and function. ROS are highly reactive oxidizing agents belonging to the class of free radicals (Aitken, 1994). A free radical is defined as ‘‘any atom or molecule that possesses one or more unpaired electrons’’ (Warren et al, 1987). Recent reports have indicated that high levels of ROS are detected in semen samples of 25% to 40% of infertile men (de Lamirande et al, 1995; Padron et al, 1997). However, a strong body of evidence suggests that small amounts of ROS are necessary for spermatozoa to acquire fertilizing capabilities (Aitken, 1999). Spermatozoa, like all cells living in aerobic conditions, constantly face the oxygen (O2) paradox: O2 is required to support life, but its metabolites such as ROS can modify cell functions, endanger cell survival, or both (de Lamirande and Gagnon, 1995). Hence, ROS must be continuously inactivated to keep only a small
X-Ray Observations of the Broad-Line Radio Galaxy 3C 390.3

We present the data and preliminary analysis for a series of 90 ROSAT HRI and two ASCA observations of the broad-line radio galaxy 3C 390.3. These data were obtained during the period 1995 January 2 to October 6 as part of an intensive multiwavelength monitoring campaign. The soft X-ray flux in the ROSAT band varied by nearly a factor of 4 during the campaign, and the well-resolved light curve shows several distinct features. Several large-amplitude flares were observed, including one in which the flux increased by a factor of about 3 in 12 days. Periods of reduced variability were also seen, including one nearly 30 days long. While the HRI hardness ratio decreased significantly, it is apparently consistent with that expected from the detector during the monitoring period. The two ASCA observations were made on 1995 January 15 and May 5. The 0.5-10.0 keV spectra can be described adequately by an absorbed power law. There is no evidence for a soft excess in the ASCA spectra, indicating that the ROSAT HRI is sampling variability of the X-ray power law. A broad iron line was observed in a longer 1993 ASCA observation, and while there is statistical evidence that the line is present in the 1995 spectra, it could not be resolved clearly. There is evidence, significant at greater than 90% confidence, that the photon index changed from 1.7 to 1.82 while the flux increased by 63%. The spectral change can be detected in the spectra below 5 keV, indicating that the origin cannot be a change in the ratio of reflected to power-law flux. A compilation of results from ASCA and Ginga observations show that on long timescales, the intrinsic photon index is correlated with the flux.
Pharmacological Doses of Daily Ascorbate Protect Tumors from Radiation Damage after a Single Dose of Radiation in an Intracranial Mouse Glioma Model

Pharmacological ascorbate is currently used as an anti-cancer treatment, potentially in combination with radiation therapy, by integrative medicine practitioners. In the acidic, metal-rich tumor environment, ascorbate acts as a pro-oxidant, with a mode of action similar to that of ionizing radiation; both treatments kill cells predominantly by free radical-mediated DNA damage. The brain tumor, glioblastoma multiforme (GBM), is very resistant to radiation; radiosensitizing GBM cells will improve survival of GBM patients. Here, we demonstrate that a single fraction (6 Gy) of radiation combined with a 1 h exposure to ascorbate (5 mM) sensitized murine glioma GL261 cells to radiation in survival and colony-forming assays in vitro. In addition, we report the effect of a single fraction (4.5 Gy) of whole brain radiation combined with daily intraperitoneal injections of ascorbate (1 mg/kg) in an intracranial GL261 glioma mouse model. Tumor-bearing C57BL/6 mice were divided into four groups: one group received a single dose of 4.5 Gy to the brain 8 days after tumor implantation, a second group received daily intraperitoneal injections of ascorbate (day 8–45) after implantation, a third group received both treatments and a fourth control group received no treatment. While radiation delayed tumor progression, intraperitoneal ascorbate alone had no effect on tumor progression. Tumor progression was faster in tumor-bearing mice treated with radiation and daily ascorbate than in those treated with radiation alone. Histological analysis showed less necrosis in tumors treated with both radiation and ascorbate, consistent with a radio-protective effect of ascorbate in vivo. Discrepancies between our in vitro and in vivo results may be explained by differences in the tumor microenvironment, which determines whether ascorbate remains outside the cell, acting as a pro-oxidant, or whether it enters the cells and acts as an anti-oxidant.
Real and Image Fields of a Relativistic Bunch

We derive analytical expressions for external fields of a charged relativistic bunch with a circular cross section. At distances far from the bunch, the field reduces to the relativistic modified Coulomb form and in the near region, reproduce the external fields of a continuous beam. If the bunch is surrounded by conducting surfaces, the bunch self-fields are modified. Image fields generated by a bunch between two parallel conducting planes are studied in detail. Exact summation of image fields by the direct method invented by Laslett allows the infinite series to be represented in terms of elementary trigonometric functions.
The Role of the Educational Leadership Program Coordinator: A Distributed Leadership Perspective

This qualitative study examined the educational leadership program coordinator's role in selected research universities, through interviews of 10 coordinators. These individuals were responsible for quasi-administrative curriculum development and outreach duties. Coordinators were committed to leading their programs despite extensive time commitments and few incentives. Two issues created barriers to distributing leadership responsibilities: faculty autonomy and program faculty size. Lacking formal authority, coordinators sometimes found it difficult to enlist the assistance of faculty colleagues. Individuals in tenure-line positions viewed their responsibilities as challenging their continued scholarly productivity, whereas those non-tenure-track positions noted that their work performance was evaluated using different criteria.
Deriving Expertise Profiles from Tags

We propose a novel approach to the problem of expertise mining in an enterprise, taking advantage of online social applications deployed within the enterprise. Based on the assumption that the users’ interactions with such social software reflect to some extent their expertise, we devise a probabilistic method for identifying the main areas of expertise of users based solely on their set of tags extracted from a social bookmarking system. We base our approach on statistical language models, which we adapt to fit our unique setting. We train and validate our model on a real world dataset extracted from two IBM-internal applications. Our results show that our approach provides a viable alternative to other methods that rely on documents extracted from the enterprise corpora.
Tourism and Economic Growth : African Evidence from Panel VAR

Using a panel Vector Autoregressive model to take into account the issue of endogeneity and causality, this paper investigated the contribution of tourism to the national income based on a sample of 40 African countries for the period 1990-2006. Results from the study confirm tourism to be an important ingredient of African development although private investment, openness and human capital remaining the main drivers. Further analysis revealed the existence of a reverse causation from national income to tourism development, thus confirming both tourism-led economic development and economicdriven tourism growth. Thus a b-icausal and reinforcing effect exist. Tourism is also observed to enhance private investment. Finally, the presence of bi-causality between private investment, education and income level is observed.
What Offers Virtual Reality to the Designer

• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
Effect of at-home bleaching with different thickeners and aging on physical properties of a nanocomposite

Objective: To evaluate the influence of 16% carbamide peroxide (CP) containing different thickeners on the physical characteristics of a nanocomposite resin submitted or not to accelerated artificial aging (AAA). Materials and Methods: One hundred samples were randomly distributed into two groups (n = 50) according to AAA. Each group was divided into 5 subgroups (n = 10) depending on the bleaching/thickener treatment: CP + carbopol, CP + natrosol, carbopol, natrosol, and no treatment (control). The physical properties tested were color (ΔE), gloss (GU), mean roughness (Ra), and Knoop microhardness (KHN). The resin surface was performed with atomic force microscopy (AFM). Statistical Analysis: The color (variable Δ E) was assessed with two-way analysis of variance (ANOVA) and additionally with Tukey's and Dunnett's tests, the roughness values were submitted to Kruskal–Wallis, Dunn's, and Mann–Whitney's tests. Data on gloss and KHN were submitted to two-way ANOVA and Tukey's test (α = 0.05). Results: Among the physical properties evaluated, CP + carbopol promoted a reduction in composite microhardness only, thus differing statistically from the controls. As for CP + natrosol, such a change was not observed. The aging process reduced all the physical properties, thus differing statistically from the nonaging group. CP + carbopol increased the roughness and decreased the gloss of aged resins, whereas natrosol reduced gloss only, which differed statistically from the controls. Conclusions: AFM showed evidence of the loss of organic matrix and exposure to load particles in the aged samples. Therefore, the replacement of carbopol with natrosol provided maintenance of the composite microhardness following bleaching. The aging process reduced the physical properties evaluated, and some changes were enhanced by the application of bleaching.
The variation in RTT of smooth TCP

Due to the way that Standard TCP is defined, it inherently provokes variation in round-trip time (RTT). A variation of TCP, referred to as Smooth TCP can, however, be configured to minimize such variations. In this paper, we review how Smooth TCP is defined and compare it with Standard TCP in an environment subject to packet errors. Such problems are very common in wireless networks, where sometimes Standard TCP considers a packet loss erroneously as a packet drop and as a consequence, large variations in RTT are introduced.
Algebras of Relations and Relevance Logic

We prove that algebras of binary relations whose similarity type includes intersection, composition, converse negation and the identity constant form a non-finitely axiomatizable quasivariety and that the equational theory is not finitely based. We apply this result to the problem of the completeness of relevant logic with respect to binary relations.
Micro Electromechanical Systems (MEMS) Based Microfluidic Devices for Biomedical Applications

Micro Electromechanical Systems (MEMS) based microfluidic devices have gained popularity in biomedicine field over the last few years. In this paper, a comprehensive overview of microfluidic devices such as micropumps and microneedles has been presented for biomedical applications. The aim of this paper is to present the major features and issues related to micropumps and microneedles, e.g., working principles, actuation methods, fabrication techniques, construction, performance parameters, failure analysis, testing, safety issues, applications, commercialization issues and future prospects. Based on the actuation mechanisms, the micropumps are classified into two main types, i.e., mechanical and non-mechanical micropumps. Microneedles can be categorized according to their structure, fabrication process, material, overall shape, tip shape, size, array density and application. The presented literature review on micropumps and microneedles will provide comprehensive information for researchers working on design and development of microfluidic devices for biomedical applications.
The Charge-Controlled Nonlinear Noise Modeling Approach for the Design of MMIC GaAs-pHEMT VCOs for Space Applications

In this paper, a new cyclostationary nonlinear low-frequency (LF) noise model for field-effect microwave transistors is presented based on the general theory of the technology-independent Charge-Controlled Nonlinear Noise modeling approach. The model definition, experimental extraction, and validation are described. For model parameter identification, the characterization of the device in terms of both LF noise in quiescent operation and its up-conversion into phase noise under large-signal RF oscillating conditions was performed using in-house developed measurement setups. The model is exploited in the design of a C-band monolithic microwave integrated circuit (MMIC) voltage-controlled oscillator (VCO) developed for space applications. The selected technology is a space-qualified GaAs 0.25-μm pseudomorphic HEMT (pHEMT) process. The large-signal technique adopted for the VCO design is also highlighted. Comparisons between measurements and simulations are provided, which show the validity of the design methodology and demonstrate the accuracy of the proposed cyclostationary noise modeling approach for phase-noise large-signal analyses of pHEMT-based circuits. The MMIC exhibits 350-MHz bandwidth at 7.3 GHz, with 14-dBm output power and -86-dBc/Hz single-sideband phase noise at 100 kHz from the carrier.
A new approach to retrieve video by example video clip

The similarity measure between video clips is a key issue in video retrieval. In the developing of our video retrieval system, we propose a new video similarity model. In contrast to existing algorithms, it proposes many influencing factors, such as order factor, speed factor, disturbance factor, etc, based on the subjective visual judgement of human. So this algorithm embodies the degree of similarity completely and systematically. On the other hand, it has resolution adaptation because it can be applied to every level of video structure. In the retrieval system, it can be used to process video query by example clip. This paper introduces it in detail and presents experiment results at the end of the paper.
Juvenile Lymnaea ventilate, learn and remember differently than do adult Lymnaea

SUMMARY Adult snails are capable of learning associatively not to perform aerial respiration and then to consolidate the acquired behaviour into long-term memory (LTM). Juvenile Lymnaea, however, perform aerial respiration significantly less often and the three-neuron circuit that drives this behaviour operates significantly differently than in it does in adults. We asked whether these ontogenic behavioural and neurophysiological differences are manifested as an altered ability of juveniles to learn and/or form LTM. We found that juvenile snails learn significantly less well than adults and are, as a group, incapable of forming LTM. To control for the possibility that the poor learning and inability to form memory were the result of juvenile's receiving on average fewer reinforcing stimuli because they perform aerial respiration less often than adults we subjected juveniles to an enforced period of hypoxia to `motivate' juveniles. Motivated juveniles perform aerial respiration as often as adults; yet these `motivated' juveniles continue to be poor learners and still cannot form LTM. Additionally, a small percentage of juveniles perform aerial respiration as often as adults (i.e. high responders). When these `high-responders were trained they still exhibited poorer learning ability compared with adults and could not form LTM. We conclude that juvenile snails have a more difficult time learning and remembering to suppress aerial respiratory activity than do adults.
Chiral Electromagnetic Fields Generated by Arrays of Nanoslits

Using a modal matching theory, we demonstrate the generation of short-range, chiral electromagnetic fields via the excitation of arrays of staggered nanoslits that are chiral in two dimensions. The electromagnetic near fields, which exhibit a chiral density greater than that of circularly polarized light, can enhance the chiroptical interactions in the vicinity of the nanoslits. We discuss the features of nanostructure symmetry required to obtain the chiral fields and explicitly show how these structures can give rise to detection and characterization of materials with chiral symmetry.