Miracle-dz/UniFAR-FTUs huggingface dataset:
Temporal variations of herbage production and nutritive value of three grasslands at different elevation zones regarding grazing needs and welfare of ruminants

Abstract Interannual and monthly variations of herbage production and nutritive value regarding grazing ruminants' needs and welfare were evaluated in three grasslands (semi-mountainous, mountainous and sub-alpine) located at different altitudes (480–900, 901–1500 and 1501–2334 m, respectively) in northern Greece during 2015–2016. Herbage biomass was collected from 30 experimental cages (10 per grassland), weighed, dried at 65 ∘C, milled and analyzed for crude protein (CP), neutral detergent fiber (NDF), acid detergent fiber (ADF), lignin, calcium (Ca) and phosphorus (P) content and in vitro dry matter digestibility (IVDMD). The sub-alpine grassland was the most productive (1031 and 1231 kg DM ha-1) with the highest mean annual herbage CP content (93 and 87 g kg-1 dry matter; DM) for 2015 and 2016, respectively. CP content was sufficient to meet small ruminants' and beef cattle maintenance requirements until April and May in the semi-mountainous and mountainous grasslands, respectively, while it could cover the above requirements in the sub-alpine grassland until June and August, respectively. The herbage Ca concentration was higher than the grazing ruminants' needs, while the phosphorus concentration was insufficient. Protein and phosphorus supplementation should be provided to animals to cover their maintenance requirements during the whole period and to reach high levels of welfare. Even though grazing is considered as a welfare-friendly procedure, it is uncertain whether all the welfare principals are satisfied in extensive production systems due to variations of forage availability and nutritive value as well as the lack of infrastructure in grasslands.
Random X Inactivation and Extensive Mosaicism in Human Placenta Revealed by Analysis of Allele-Specific Gene Expression along the X Chromosome

Imprinted inactivation of the paternal X chromosome in marsupials is the primordial mechanism of dosage compensation for X-linked genes between females and males in Therians. In Eutherian mammals, X chromosome inactivation (XCI) evolved into a random process in cells from the embryo proper, where either the maternal or paternal X can be inactivated. However, species like mouse and bovine maintained imprinted XCI exclusively in extraembryonic tissues. The existence of imprinted XCI in humans remains controversial, with studies based on the analyses of only one or two X-linked genes in different extraembryonic tissues. Here we readdress this issue in human term placenta by performing a robust analysis of allele-specific expression of 22 X-linked genes, including XIST, using 27 SNPs in transcribed regions. We show that XCI is random in human placenta, and that this organ is arranged in relatively large patches of cells with either maternal or paternal inactive X. In addition, this analysis indicated heterogeneous maintenance of gene silencing along the inactive X, which combined with the extensive mosaicism found in placenta, can explain the lack of agreement among previous studies. Our results illustrate the differences of XCI mechanism between humans and mice, and highlight the importance of addressing the issue of imprinted XCI in other species in order to understand the evolution of dosage compensation in placental mammals.
Hierarchical neural networks for text categorization (poster abstract)

This paper presents the design and evaluation of a text categorization method based on the Hierarchical Mixture of Experts model. This model uses a divide and conquer principle to define smaller categorization problems based on a predefined hierarchical structure. The final classifier is a hierarchical array of neural networks. The method is evaluated using the UMLS Metathesaurus as the underlying hierarchical structure, and the OHSUMED test set of MEDLINE records. Comparisons with traditional Rocchio’s algorithm adapted for text categorization, as well as flat neural network classifiers are provided. The results show that the use of the hierarchical structure improves text categorization performance significantly.
Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank

A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1 possesses a β-d-xylopyranose. The structures of the new compounds were elucidated on the basis of spectroscopic analyses. The cytotoxicities of compounds 1–4 against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of these new compounds 1–4 were also evaluated by measuring their ability to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils. Compounds 2 and 3 were shown to exhibit significant cytotoxicity, and compounds 3 and 4 were also found to display attracting anti-inflammatory activities.
Morphological and genetic characterization of bloom‐forming Raphidophyceae from Brazilian coast

Massive fish kills caused by bloom‐forming species of the Raphidophyceae occur in many marine coastal areas and often cause significant economic losses. The ultrastructure and phylogeny of marine raphidophytes from the Brazilian coast have not been fully analyzed. Here, we present the first combined morphological and genetic characterization of raphidophyte strains from the Brazilian coast. Ten strains of four raphidophyte species (Chattonella subsalsa, C. antiqua, Heterosigma akashiwo, and Fibrocapsa japonica) were characterized based on morphology (including ultrastructure) and LSU rDNA sequences. Chattonella subsalsa and C. antiqua formed two distinct genetic clades. We found that the cell size is the only phenotypic feature separating C. subsalsa and C. antiqua strains from Brazil, whereas traditional characteristics used for species separation in the genus Chattonella (i.e., tail size, chloroplast presence in the tail, ‘oboe‐shaped’ mucocysts, and presence of thylakoids in the pyrenoid matrix) were not sufficiently discriminative, due to their overlapping in the two taxa. The phylogenetic analysis indicated intra‐specific geographic differences among C. subsalsa sequences, with two subclades: one formed by isolates from Brazil, USA, and Iran, and another by a sequence from the Adriatic Sea (Italy). Fibrocapsa japonica also showed intra‐specific geographic differences, with a sequence from a Brazilian strain grouped with strains from Japan, Australia, and Germany, all of them distinct from the Italian isolates. This is the first combined morphological and phylogenetic analysis of raphidophytes from the South Atlantic. Our findings broaden knowledge of the biodiversity of this important bloom‐forming algal group.
Synergistic Computational and Experimental Proteomics Approaches for More Accurate Detection of Active Serine Hydrolases in Yeast

An analysis of the structurally and catalytically diverse serine hydrolase protein family in the Saccharomyces cerevisiae proteome was undertaken using two independent but complementary, large-scale approaches. The first approach is based on computational analysis of serine hydrolase active site structures; the second utilizes the chemical reactivity of the serine hydrolase active site in complex mixtures. These proteomics approaches share the ability to fractionate the complex proteome into functional subsets. Each method identified a significant number of sequences, but 15 proteins were identified by both methods. Eight of these were unannotated in the Saccharomyces Genome Database at the time of this study and are thus novel serine hydrolase identifications. Three of the previously uncharacterized proteins are members of a eukaryotic serine hydrolase family, designated as Fsh (family of serine hydrolase), identified here for the first time. OVCA2, a potential human tumor suppressor, and DYR—SCHPO, a dihydrofolate reductase from Schizosaccharomyces pombe, are members of this family. Comparing the combined results to results of other proteomic methods showed that only four of the 15 proteins were identified in a recent large-scale, “shotgun” proteomic analysis and eight were identified using a related, but similar, approach (neither identifies function). Only 10 of the 15 were annotated using alternate motif-based computational tools. The results demonstrate the precision derived from combining complementary, function-based approaches to extract biological information from complex proteomes. The chemical proteomics technology indicates that a functional protein is being expressed in the cell, while the computational proteomics technology adds details about the specific type of function and residue that is likely being labeled. The combination of synergistic methods facilitates analysis, enriches true positive results, and increases confidence in novel identifications. This work also highlights the risks inherent in annotation transfer and the use of scoring functions for determination of correct annotations.
Quantization table design revisited for image/video coding

Quantization table design is revisited for image/video coding where soft decision quantization (SDQ) is considered. Unlike conventional approaches where quantization table design is bundled with a specific encoding method, we assume optimal SDQ encoding and design a quantization table for the purpose of reconstruction. Under this assumption, we model transform coefficients across different frequencies as independently distributed random sources and apply the Shannon lower bound to approximate the rate distortion function of each source. We then show that a quantization table can be optimized in a way that the resulting distortion complies with certain behavior. Lastly, guided by this new theoretical result, we propose an efficient statistical-model-based algorithm using the Laplacian model to design quantization tables for JPEG encoding. Compared with the state of the art, the proposed algorithm provides an average 0.5 dB gain in PSNR with computational complexity reduced by a factor of more than 2000 when SDQ is off, and a 0.1 dB performance gain with 85% of the complexity reduced when SDQ is on.
Inversion of moment tensor focal mechanisms for active stresses around the microcontinent Iberia: Tectonic implications

The Iberian microcontinent and its connected oceanic crust are affected by deformations related to the Eurasian‐African plate boundary. Active stress inversions from populations of moment tensor focal mechanisms have been performed around and inside the Iberian peninsula, using a total of 213 moment tensor estimates. Main results are as follows: (1) The tensorial solutions show better consistency and lower misfits compared to those obtained previously from first P arrival focal mechanisms. (2) Along the Eurasia‐Africa western boundary, the type of active stresses progressively changes easternward from triaxial extension to uniaxial compression along the Terceira Ridge, the Gloria Fault zone, and the Gulf of Cadiz. (3) In the Betics‐Alboran‐Rif zone, uniaxial extension predominates with Shmax N155°E trending. (4) In northern Algeria, uniaxial compression reappears. (5) The Iberian foreland is currently under strike‐slip to uniaxial extension tensorial conditions.
Application delay modelling for variable length packets in single cell IEEE 802.11 WLANs

In this paper, we consider the problem of modelling the average delay experienced by an application packets of variable length in a single cell IEEE 802.11 DCF wireless local area network. The packet arrival process at each node i is assumed to be a stationary and independent increment random process with mean ai and second moment ai(2). The packet lengths at node i are assumed to be i.i. d random variables Pi with finite mean and second moment. A closed form expression has been derived for the same. We assume the input arrival process across queues to be uncorrelated Poison processes. As the nodes share a single channel, they have to contend with one another for a successful transmission. The mean delay for a packet has been approximated by modelling the system as a 1-limited Random Polling system with zero switchover times. Extensive simulations are conducted to verify the analytical results.
Synthesis and Biological Evaluations of a Novel Oxidovanadium(IV) Adenosine Monophosphate Complex as Anti-Diabetic Agent

In the present study, a novel [(AMP)(VO)(H2O)2] complex was formed through chemical reactions between oxidovanadium(IV)sulfate and adenosine monophosphate. This complex was characterized using various analyses, including microanalytical, molar conductivity, spectroscopic (solid reflectance and FTIR), magnetic susceptibility, thermogravimetric (TGA), X-ray powder diffraction (XRD), and scanning (SEM) and transmission (TEM) electron microscopy. The in vivo antidiabetic activity of the oxidovanadium(IV) complex was determined using streptozotocin-induced rats. The results suggested that the synthesized complex can be used as an antidiabetic agent based on the observed biochemical effects.
Commentary on Gruhn et al.'s "How Stable is Pitch Labeling Accuracy in Absolute Pitch Possessors?"

In this commentary, I discuss the results and implications of "How stable is pitch labeling accuracy in absolute pitch possessors? " by Gruhn, Ristmägi, Schneider, D'Souza, and Kiilu (2018). Their work provides some new insights on the accuracy of single tone labeling by absolute pitch (AP) possessors as a function of the spectral content of the presented tones. Previous findings on the effects of the familiarity of timbre and pitch chroma and early training in music are replicated and confirmed, indicating a role of learning and exposure in AP development. Prospects for future research are discussed, including the necessity of a validated psychometric instrument for measuring AP ability, and the need for longitudinal developmental research to more precisely isolate the factors that contribute to AP acquisition.
Is Reperfusion Useful in Ischaemic Stroke Patients Presenting with a Low National Institutes of Health Stroke Scale and a Proximal Large Vessel Occlusion of the Anterior Circulation?

Background: In population-based studies, patients presenting with minor or mild stroke symptoms represent about two-thirds of stroke patients, and almost one-third of these patients are unable to ambulate independently at the time of discharge. Although mechanical thrombectomy (MT) has become the standard of care for acute ischaemic stroke with proximal large vessel occlusion (LVO) in the anterior circulation, the management of patients harbouring proximal occlusion and minor-to-mild stroke symptoms has not yet been determined by recent trials. The purpose of this study was to evaluate the impact of reperfusion on clinical outcome in low National Institutes of Health Stroke Scale (NIHSS) patients treated with MT. Methods: We analysed 138 consecutive patients with acute LVO of the anterior circulation (middle cerebral artery M1 or M2 segment, internal carotid artery or tandem occlusion) with NIHSS <8, having undergone MT in 3 different centres. Reperfusion was graded using the modified thrombolysis in cerebral infarction (TICI) score and 3 grades were defined, ranging from failed or poor reperfusion (TICI 0, 1, 2A) to complete reperfusion (TICI 3). The primary clinical endpoint was an excellent outcome defined as a modified Rankin score (mRs) 0-1 at 3-months. The impact of reperfusion grade was assessed in univariate and multivariate analyses. The secondary endpoints included favourable functional outcome (90-day mRS 0-2), death and safety concerns. Results: Successful reperfusion was achieved in 81.2% of patients (TICI 2B, n = 47; TICI 3, n = 65). Excellent outcome (mRs 0-1) was achieved in 69 patients (65.0%) and favourable outcome (mRs ≤2) in 108 (78.3%). Death occurred in 7 (5.1%). Excellent outcome increased with reperfusion grades, with a rate of 34.6% in patients with failed/poor reperfusion, 61.7% in patients with TICI 2B reperfusion, and 78.5% in patients with TICI 3 reperfusion (p < 0.001). In multivariate analysis adjusted for patient characteristics associated with excellent outcome, the reperfusion grade remained significantly associated with an increase in excellent outcome; the OR (95% CI) was 3.09 (1.06-9.03) for TICI 2B and 6.66 (2.27-19.48) for TICI 3, using the failed/poor reperfusion grade as reference. Similar results were found regarding favourable outcome (90-day mRs 0-2) or overall mRS distribution (shift analysis). Conclusion: Successful reperfusion is strongly associated with better functional outcome among patients with proximal LVO in the anterior circulation and minor-to-mild stroke symptoms. Randomized controlled studies are mandatory to assess the benefit of MT compared with optimal medical management in this subset of patients.
Automatic Detection of Lung and Liver Lesions in 3-D Positron Emission Tomography Images: A Pilot Study

Positron emission tomography (PET) using fluorine-18 deoxyglucose (18F-FDG) has become an increasingly recommended tool in clinical whole-body oncology imaging for the detection, diagnosis, and follow-up of many cancers. One way to improve the diagnostic utility of PET oncology imaging is to assist physicians facing difficult cases of residual or low-contrast lesions. This study aimed at evaluating different schemes of computer-aided detection (CADe) systems for the guided detection and localization of small and low-contrast lesions in PET. These systems are based on two supervised classifiers, linear discriminant analysis (LDA) and the nonlinear support vector machine (SVM). The image feature sets that serve as input data consisted of the coefficients of an undecimated wavelet transform. An optimization study was conducted to select the best combination of parameters for both the SVM and the LDA. Different false-positive reduction (FPR) methods were evaluated to reduce the number of false-positive detections per image (FPI). This includes the removal of small detected clusters and the combination of the LDA and SVM detection maps. The different CAD schemes were trained and evaluated based on a simulated whole-body PET image database containing 250 abnormal cases with 1230 lesions and 250 normal cases with no lesion. The detection performance was measured on a separate series of 25 testing images with 131 lesions. The combination of the LDA and SVM score maps was shown to produce very encouraging detection performance for both the lung lesions, with 91% sensitivity and 18 FPIs, and the liver lesions, with 94% sensitivity and 10 FPIs. Comparison with human performance indicated that the different CAD schemes significantly outperformed human detection sensitivities, especially regarding the low-contrast lesions.
Continuous shear rheometry of o/w emulsions; control of evaporation in cone/plate geometry

Volatile solvents may evaporate during cone/plate viscometry so that false rheograms develop. This surface evaporation was prevented in a cod‐liver oil‐in‐water emulsion stabilized with zanthoxylum gum by layering a film of cod‐liver oil on the exposed surface of the emulsion test sample. The oil layer effectively prevented evaporation and did not alter significantly the rheological behaviour of the test material.
A comprehensive review of blood product use in civilian mass casualty events

I recent decades, there has been a significant increase in the frequency of disasters and major emergencies. By definition, these mass casualty events (MCEs) result in large numbers of severely injured patients, which overwhelm available resources, thereby limiting the ability to deliver optimal care. In these casualties, hemorrhage is a leading cause of preventable mortality, accounting for almost 50% of deaths in the first 24 hours. Modern transfusion strategies recommend high ratios of blood components, such as fresh frozen plasma (FFP) to red blood cells (RBCs) from the outset as part of damage-control resuscitation (DCR). The timely availability and appropriate delivery of blood products in MCEs is essential to improve critical mortality in severely injured patients. Emergency preparedness for future MCEs must therefore include evidence-based transfusion strategies and blood bank planning. Predicting blood product requirements for MCEs is challenging. Previous studies of events, in both military and civilian settings, have been based on single-center experiences and quantified RBC requirements by units used per victim or per hospitalized patient. In civilian and military trauma, casualty blood requirements depend on factors such as injury severity and mechanism of injury (MOI). Some of this information may not be applicable or readily available in MCEs. Past experience of blood use in MCEs has indicated that held stocks of RBCs have been adequate for a hospitals’ capacity to deliver them to patients. Despite this, there are continued reports of emergency donation following MCEs suggesting stock availability in blood banks and demand requires further investigation. In conjunction with this, transfusion strategies in trauma have evolved in recent years with the advent of DCR using early high-dose coagulation therapy alongside RBCs to prevent and treat coagulopathy. This new approach has not been explored fully in the context of MCEs and the potential impact it may have on supply and demand during these events. The overall objective of this article was to determine if blood requirements necessary to adequately manage a civilian MCE are predictable based on historical data and events. The first aim of the study was to perform a review of the adequacy of reporting of blood product use across a full range of civilian MCEs. Second, we wished to determine whether a predictive relationship exists between blood use and available casualty profiles. The third aim was to determine whether any existing relationship is affected by the nature of the event itself. Finally, we wished to investigate the potential effect that current trauma transfusion practices would have had on blood demands during previous events. We conducted a comprehensive review of literature from 1911 to 2011 and compared findings with civilian blood use data from a major trauma center.