Miracle-dz/UniFAR-FTUs huggingface dataset:
Metabolism of Very Low Density Lipoproteins in Hyperlipidaemia: Studies of Apolipoprotein B Kinetics in Man

The metabolism of very low density lipoprotein‐B (VLDL‐B) peptide was studied in nineteen subjects with endogenous hypertrigylceridaemia (Types V, IV and lib), three patients with heterozygous familial hyperbetalipoproteinaemia (Type Ila) and eight healthy subjects, by reinjecting autologous radioiodinated VLDL. The kinetics of VLDL‐B peptide were followed. The mean turnover rate of VLDL‐B peptide was significantly higher in the hypertriglyceridaemic group than in the control group but a considerable overlap in turnover rate was found between these groups. The patients with heterozygous familial hyperbetalipoproteinaemia had a normal turnover rate of VLDL‐B peptide. A significant positive correlation was found between the turnover rate of VLDL‐B peptide and VLDL‐triglyceride concentration in the whole series.
Long-memory in high-frequency exchange rate volatility under temporal aggregation

This paper applies log-periodogram estimators of the fractional difference parameter to the volatility of the US dollar exchange rate returns of 11 European currencies, and under temporal aggregation from an underlying half-hourly intra-day frequency. Particular attention is paid to the sequencing of the nonlinear transformation of returns and their temporal aggregation. The results reported confirm that long-memory in absolute returns constitutes an intrinsic and empirically significant characteristic of the exchange rates considered. At the practical level, our results lend support to the proposal that nonlinear transformation prior to temporal aggregation can return meaningful long-memory parameter estimates. Our findings also illustrate the advantages of long-memory parameter estimation based on the smoothed periodogram applied to absolute returns in controlling for noise induced by temporal aggregation in the processing of high-frequency data.
Three Scenarios for the Future of Technology and Strong Democracy

Modernity may be defined politically by the institutions of democracy, and socially and culturally by the civilization of technology. The relationship between democracy and technology remains ambiguous, however. Proponents of classical participatory democracy such as Jean Jacques Rousseau have generally understood the progress of science to be corrosive to the intimacy and equality of political relations. Proponents of the liberal open society such as Sir Karl Popper and Bertrand Russell, however, have posited a close connection between the spirit of science and the success of liberal democratic institutions. About the future role of democracy in society we cannot be certain. Because it is a fragile form of social organization, its prospects are clouded. But we do know, however we organize our political world, that we shall live in a society dominated by technology. Indeed, the theme of technology and society has become sufficiently popular to make it a favorite both with academics and after dinner speakers. Notwithstanding it being in vogue, the relationship between technology and democracy is a matter of genuine urgency for modern men and women. Will technology nourish or undermine democratic institutions? Is technological growth likely to support or corrupt freedom? Are we finally to be mastered by the tools with which we aspire to master the world? The scientistic wisdom suggests that science and technology, by opening up society and creating a market of ideas, foster more open politics; the Soviet experience with copying ma-
Imports, Productivity and Origin Markets: The Role of Knowledge-Intensive Economies

We investigate the impact of international knowledge transfers on productivity at the firm level. The flow of knowledge across borders is measured through imports from different markets. Using a dynamic panel GMM estimation on Swedish manufacturing firms with 10 or more employees over the period 1997–2004, three important results emerge. First, there is an instantaneous positive effect of imports on productivity. Second, the evidence points towards a distinct role of imports from the G7 countries, which accounts for 80 per cent of global R&D. Third, sensitivity analyses show that G7 imports are also important for small and non-affiliated firms.
The Moderating Effects of Family Control on the Relation between Managerial Overconfidence and Earnings Management

This study investigates the relation between managerial overconfidence and earnings management and whether this relation is moderated by family control. Using a sample of Taiwan-listed firms, we estimate managerial overconfidence from manager dealings and determine the following: First, overconfident managers are more likely to engage in earnings management behaviors; second, family control negatively moderates the positive relation between managerial overconfidence and earnings management; and third, the negative moderating effects of family control primarily result from family chief executive officers.
Estimation of the size of the chromosome 17pll .2 duplication in Charcot-Marie-Tooth neuropathy type la (CMTla)

Wehave previously shown a duplication in 17p11.2 with probe pVAW409R3 (D17S122) in 12 families with hereditary motor and sensory neuropathy type I (HMSN I) or Charcot-Marie-Tooth disease type 1 (CMT1). In this study we aimed to estimate the size of the duplication using additional polymorphic DNA markers located in 17pll.2-p12.
Joint Resource Scheduling for Mobile Multimedia Services in Hierarchical Cloud Networks

With the explosive growth of Mobile Internet applications, the massive amount of data traffic produced by the data applications, such as mobile multimedia services, will bring big challenge to the next generation (5G) mobile communication networks. Recently, hierarchical cloud service networks have been proposed to address this big challenge. By introducing distributed hierarchical cloud network architecture, mobile users can enjoy efficient high-quality and low-delay local services. However, with the limited resources in the hierarchical cloud networks, it is essential to develop efficient resource scheduling and content delivery mechanisms. In this paper, we investigate the resource allocation for hierarchical cloud networks. We propose a Joint Resource Allocation (JRA) scheme, aiming at improving resource utilization, as well as reducing the content access delay to improve user Quality of Experience (QoE). Our fundamental idea is to jointly allocate spectrum and energy resources in wireless networks, caching and processing resources in Cloudlets, to maximize overall system resource utilization. We conduct simulation experiments to validate the effectiveness of our proposed JRA scheme. Numerical results show that the performance of JRA in terms of content access delay and resource utilization can be significantly improved compared with traditional schemes.
A cloned ompR‐like gene of Streptomyces lividans 66 suppresses defective melC1, a putative copper‐transfer gene

Expression of tyrosinase in Streptomyces requires functional MelC1 protein, which is postulated to transfer copper to apotyrosinase. We have previously isolated a mutant of Streptomyces lividans, HT32, that phenotypically suppressed mutations in cloned melC1 (H.‐C. Tseng and C. W. Chen, in preparation). Plasmid pLUS132, containing an ATG to ATA transition at the initiation codon of melC1, was used for cloning the suppressor gene from HT32. A 1687bp suppressor DNA was isolated that contained two characteristic Streptomyces coding sequences: a 217‐amino‐acid open reading frame (cutR) and a truncated open reading frame (cutR) downstream. Subcloning analysis attributed the phenotypic suppression activity to the putative cutR gene from HT32. The putative CutR exhibited similarity to the response regulator OmpR of the osmoregulatory signal‐transduction system in Escherichia coli. The truncated CutS resembled, to a lesser degree, the N‐terminus of EnvZ, the histidine protein kinase counterpart of OmpR. DNA hybridizing to the cloned cutR‐cutS sequence was detected in 16 other Streptomyces species. We postulate that the putative cutR‐cutS operon regulates copper metabolism in Streptomyces.
Internal and external influences on adoption decisions in multi-unit firms: the moderating effect of experience

Facing uncertainty about whether to adopt a new technology, firms rely on both external and internal sources of information. Firms may learn vicariously about the desirability of adoption; a large body of research has demonstrated a tendency for firms to imitate rival adopters. Organizations with multiple units may also learn from their own experience once an initial unit of the firm has adopted. This article uses data on the establishment of websites by consumer magazines during the early internet era to test the hypothesis that multi-unit firms pay less attention to rivals after an initial unit of the firm has adopted. Consistent with this hypothesis, it is found that the influence of rivals drops sharply following the initial adoption. One explanation for the shift is that vicarious learning becomes less valuable once richer information becomes available from internal sources.
Capital We Must Develop: Emotional Competence Educating Pre-Licensure Nursing Students

AbstractEmotional competency is a skill commonly overlooked within the nursing curriculum. However, with the complexity of the health care environment and increased emphasis on team collaboration, nurse educators who focus on health promotion and technical, medical, and organizational competencies need to consider adding a focus on soft skills, such as emotional competency. This pilot study engaged 14 pre-licensure nursing students who were involved in an 18-month leadership program. Pre-post scores of the Emotional and Social Competency Inventory are described. Statistical significance was found with three core areas: emotional self-awareness, emotional self-control, and inspirational leadership.
Labor Unions as Shareholder Activists: Champions or Detractors?

This paper examines the impact of labor union shareholder activism through the submission of shareholder proposals during 1988-2002. We examine the effect of labor union sponsored shareholder proposals on announcement period returns, on the corporate governance environment of the firm including shareholder rights, board composition, and CEO compensation, and on long run shareholder wealth. We find that the efficacy of activism is related to union presence at targeted firms and shareholder support for proposals. Our findings, hitherto not reported elsewhere, contribute to the shareholder activism literature by implying that labor unions may be unique in their ability to spur such changes relative to other shareholder proponents.
Study on the accuracy of forward modeling in electrical impedance tomography for thorax imaging

In this paper, we study the data calibration procedure in electrical impedance tomography (EIT) for thorax imaging. Data calibration is an important procedure in EIT imaging as it bridges the gap between simulated data and measured data. Minimizing the systematic error caused by forward modeling could significantly improve the quality of reconstruction. A few factors are investigated in this study including: 1) electrode model; 2) skin impedance; 3) dimensionality of forward modeling. We observe that the dimensionality of forward modeling is the most critical factor. In fact, simulated data comparable with the experimental data can be obtained using three-dimensional forward modeling and reasonable estimation of background conductivity. It can serve as a good starting point for EIT data inversion. Finally, we perform a fully three-dimensional reconstruction using the measured data of human pulmonary ventilation. The reconstructed images further support our conclusion.
Relations between funding, equity, and efficiency of higher education

Funding, equity, and efficiency of higher education are three dimensions of higher education that have been of increasing interest to scholars and policy‐makers during the past two decades in Europe and elsewhere. Analysing these phenomena and the relations between them is the main topic of this paper, considering the funding system as the basic issue. The paper presents each of three phenomena using a joint approach (definition of the phenomenon, its measurement, prevailing global world trends) and endeavours to explore the possibilities of measuring their mutual relationships.
Assurance of Australian Natural Resource Management

Abstract This article traces the challenges encountered in the development of appropriate guidance for an Australian public sector organization embarking on meeting its legislated responsibility of carrying out audits of natural resource management practices and performance, a new and challenging field of audit. The evidence suggests that the development of such guidance is complex, involving significant research development and innovation in which the current array of existing standards or guidance on sustainability and audit were of limited value.
Noise Prediction and Sound Quality Analysis of Variable-Speed Permanent Magnet Synchronous Motor

A multiphysics model is proposed to predict electromagnetic noise and analyze sound quality of permanent magnet synchronous motor with a variable speed range. First, a two-dimensional electromagnetic finite element model is built and the current during run-up is tested to serve as the input of the model for force calculation. The force is transferred to structural model and the mode superposition method is used to predict vibration. Then, based on the structural mode information and acoustic transfer vector, noise transfer function between electromagnetic force and sound pressure is established. A balanced efficiency and accuracy of noise calculation during run-up is achieved with this function. Finally, psychoacoustical indices are calculated to evaluate the sound quality with the influence of current harmonics into consideration. The calculated vibration and noise are experimentally validated and the errors of noise level in the whole speed range are all below 4 dB. It is also concluded that current harmonics greatly deteriorate the sound quality.
Does a new undergraduate curriculum based on Tomorrow's Doctors prepare house officers better for their first post? A qualitative study of the views of pre‐registration house officers using critical incidents

Introduction In 1994 Manchester University introduced an integrated undergraduate medical course using problem‐based learning (PBL) throughout. The study reported here explored whether there were any differences between the new course graduates (NCGs) and the traditional course graduates (TCGs) in the types of scenarios they recalled as ‘critical incidents’, or challenging cases, while working as pre‐registration house officers (PRHOs). The focus is on differences rather than causal links.
Conditional eco-efficiency measure from the perspective of pollution emission firms

This paper proposes a conditional eco-efficiency measure with constraints to profit and pollution goals from the perspective of pollution emission firms. The measure is obtained not only by comparing the relative performance to other decision-making units (DMUs), but also by comparing the existing level relative to expected profit and pollution goals. We use the proposed measure to appraise the eco-efficiency of 32 paper mills along the Huai River in China, and discuss the sensitivity of eco-efficiency with some varying parameters. Different from the previous eco-efficiency measures, our technique admits the selfish motives of pollution emission firms which have little motivation to minimise the pollution emission. As a result, the current approach can be accepted by pollution emission firms for providing feasible strategies in performance improvement.
An E-Strategy for Online E-Business

Abstract Both new E-business start-ups and current businesses that are investigating the possibility of migrating to an E-business system need to have an E-strategy. However, the potential E-business needs to decide on whether it will be focused on business processes or whether it will force action on the real business needs to sustain long-term longevity. To stay competitive today, businesses must realize that the customer is becoming more and more important. Hence the market has developed into a customer-driven market, with businesses becoming customer-centric, if they are not already, and not purely business-centric as in the past. This article investigates and develops a comprehensive E-strategy to enable a review of an E-business's needs. Issues that are addressed here will have an impact on how businesses achieve their desired goals. By following guidelines outlined in this article, which highlight both critical success factors and potential problems, an E-business will be able to evaluate whether it is ready to move forward and commit wholeheartedly to the new channel of business.
Chemistry and Biology of Proteins

forth effort at the proper times. Immediately following is a chapter entitled "The Psychology of Labor" in which the sensations of the different stages are described, as well as the actual mechanics of the hospital admission and the various procedures usually carried out during labor and delivery. A discussion of breast feeding and of the "rooming-in" plan is included. The concluding chapters deal with the post-partum period and contain suggestions on diet, hygiene, and exercises for the mother. The subject is treated realistically and practically. The style is informal and the language simple and straightforward. The book is adequately indexed and contains diagrams and anatomical illustrations appropriate to the text. Many questions which arise during the course of pregnancy are answered in this little book; its principle purpose is to relieve fears and tensions by preparing the mother both mentally and physically for childbirth.
Dual Control of Muscle Cell Survival by Distinct Growth Factor-Regulated Signaling Pathways

ABSTRACT In addition to their ability to stimulate cell proliferation, polypeptide growth factors are able to maintain cell survival under conditions that otherwise lead to apoptotic death. Growth factors control cell viability through regulation of critical intracellular signal transduction pathways. We previously characterized C2 muscle cell lines that lacked endogenous expression of insulin-like growth factor II (IGF-II). These cells did not differentiate but underwent apoptotic death in low-serum differentiation medium. Death could be prevented by IGF analogues that activated the IGF-I receptor or by unrelated growth factors such as platelet-derived growth factor BB (PDGF-BB). Here we analyze the signaling pathways involved in growth factor-mediated myoblast survival. PDGF treatment caused sustained activation of extracellular-regulated kinases 1 and 2 (ERK1 and -2), while IGF-I only transiently induced these enzymes. Transient transfection of a constitutively active Mek1, a specific upstream activator of ERKs, maintained myoblast viability in the absence of growth factors, while inhibition of Mek1 by the drug UO126 blocked PDGF-mediated but not IGF-stimulated survival. Although both growth factors activated phosphatidylinositol 3-kinase (PI3-kinase) to similar extents, only IGF-I treatment led to sustained stimulation of its downstream kinase, Akt. Transient transfection of a constitutively active PI3-kinase or an inducible Akt promoted myoblast viability in the absence of growth factors, while inhibition of PI3-kinase activity by the drug LY294002 selectively blocked IGF- but not PDGF-mediated muscle cell survival. In aggregate, these observations demonstrate that distinct growth factor-regulated signaling pathways independently control myoblast survival. Since IGF action also stimulates muscle differentiation, these results suggest a means to regulate myogenesis through selective manipulation of different signal transduction pathways.
Free Trade Impacts On U.S. And Southern Agriculture

In June 1991, the United States and Mexico agreed to work toward the formation of a free trade area (FTA), in which trade barriers between the two countries will be gradually reduced and eUrninated. An FTA is expected to deepen a trade relationship that has always been important to the two countries, and which has been expanded by the unilateral trade liberalization initiated by Mexico in 1983. A U.S. Mexico FTA will be an important development for U.S. agriculture. In 1990, Mexico ranked among the top four markets for U.S. agricultural exports nd imports. Mexico's share of U.S. agricultural trade has increased since the mid-1980s, and could expand further if trade barriers are removed.
MFCC feature with optimized frequency range: An essential step for emotion recognition

One of the major challenge in human emotion recognition is extraction of features containing maximum prosodic information. The accuracy of entire emotion detection system eventually relies upon the efficiency of the selected feature. When it comes to identifying emotions from voice, ambiguity in detection can never be completely avoided due to several reasons. Exclusion of redundant information to reduce confusion in recognizing emotions is quite challenging. The primary objective of this work is to improve the accuracy of existing emotion recognition method that uses Mel frequency Cepstral Coefficient (MFCC) feature. In this work, an additional step has been introduced to the method to make it more efficient for recognizing emotions from voice. Instead of taking the whole signal frequency range for filter bank analysis in MFCC computation, it has been suggested to optimize the analysis frequency range for maximum accuracy. The proposed method has been tested on two standard speech emotion databases: Berlin Emo-DB database [1] and Assamese database [2]. The addition of this extra step has been found to be increasing speaker-independent emotion recognition accuracy by 15% for Assamese database and around 25% for Berlin database.
Calcium-Calmodulin-induced Dimerization of the Carboxyl-terminal Domain from Petunia Glutamate Decarboxylase

The acidic, bilobed protein calmodulin (CaM; molecular mass of 16.7 kDa) can activate some 40 distinct proteins in a calcium-dependent manner. The majority of the CaM-binding domain regions of the target proteins are basic and hydrophobic in nature, are devoid of multiple negatively charged residues, and have a propensity to form an α-helix. The CaM-binding domain in the C-terminal region of petunia glutamate decarboxylase (PGD) is atypical because it contains five negatively charged residues. Therefore, we chose to study the binding of calcium-CaM to a 26-residue synthetic peptide encompassing the C-terminal region of PGD. Gel band shift assays, fluorescence spectroscopy, and NMR titration studies showed that a single unique complex of calcium-CaM with two PGD peptides is formed. The formation of a 1:2 protein-peptide complex is unusual; normally, calcium-CaM forms 1:1 complexes with the majority of its target proteins. Circular dichroism spectroscopy showed that the bound PGD peptides have an α-helical structure. NMR studies of biosynthetically [methyl-13C]methionine-labeled CaM revealed that all the Met side chains in CaM are involved in the binding of the PGD peptides. Analysis of fluorescence spectra showed that the single Trp residue of the two peptides becomes bound to the N- and C-terminal lobes of CaM. These results predict that binding of calcium-CaM to PGD will give rise to dimerization of the protein, which may be necessary for activation. Possible models for the structure of the protein-peptide complex, such as a dimeric peptide structure, are discussed.