Miracle-dz/UniFAR-FTUs huggingface dataset:
TC-DSA: topology control for delay sensitive applications in wireless sensor networks

Energy limitations in wireless sensor networks and the need for low latency in many applications require a unified approach in the design of network protocols. In this paper, we propose a distributed wakeup schedule to accomplish a new topology control scheme. The aim is to increase the longevity of the network for a given upper bound on the average end-to-end delay. In the proposed scheme neither localization nor synchronization is required and only local information is used. In addition to its simplicity of implementation, its energy overhead is negligible and it implicitly determines the routing paths. Our simulation results show that this protocol achieve significant improvement in the network lifetime compared to SPAN, an existing topology control mechanism.
Steroid metabolism and effects in central and peripheral glial cells.

Hormonal steroids participate in the control of a large number of functions of the central nervous system (CNS); recent data show that they may also intervene at the level of the peripheral nervous system (PNS). Both the CNS and the PNS metabolize endogenous as well as exogenous steroids; one of the major enzymatic system is represented by the 5alpha-reductase-3alpha-hydroxysteroid complex. This is a versatile system, since every steroid possessing the delta 4-3keto configuration (e.g., testosterone, progesterone, deoxycorticosterone) may be a substrate. High levels of 5alpha-reductase are found in the white matter of the CNS and in purified myelin. The observation that, in addition to neurons, glia may be a target for steroid action is an important recent finding. The effects of progesterone, testosterone, corticoids, and their respective 5alpha and 3alpha-5alpha derivatives on the expression of glial genes are presented and discussed. It has also been found that progesterone and/or its 5alpha-reduced metabolites increase the mRNA for the two major proteins of peripheral myelin, the glycoprotein Po and the peripheral myelin protein 22, in the sciatic nerve of normal and aged animals and in Schwann cells. The hypothesis has been put forward that glycoprotein Po might be under the control of progestagens acting mainly via the progesterone receptor, and that peripheral myelin protein 22 might be controlled via an interaction of steroids with the gamma-aminobutyric acid (GABA)ergic system. It is known that tetrahydroprogesterone, the 3alpha-5alpha-reduced metabolite of progesterone, interacts with the GABA(A) receptor. Our recent data show that several subunits of this receptor are present in sciatic nerve as well as in Schwann cells that reside in this nerve. These data open multiple possibilities for new therapeutic approaches to demyelinating diseases.
Is sentiment analysis an art or a science? Impact of lexical richness in training corpus on machine learning

Social Media is exploding with data - that can help you derive an optimal marketing strategy in the internet world, engage with your audience on the fly, and protect your reputation from smearing campaigns if it is processed and analyzed in a timely fashion. Digital marketing analysts and data scientists rely on social media analytics tools to deduce customer sentiment from countless opinions and reviews. While numerous attempts have been made to improve their accuracy in the past, yet we know surprisingly little about how accurate their results are. We present an unbiased study of users' tweets and the methods that leverage the available tools & technologies for opinion mining. Our prime focus is on improving the consistency of text classifiers used for linguistic analysis. We also measure the impact of lexical richness in the sample data on the trained algorithm. This paper attempts to improve the reliability of sentiment classification process by the creation of a custom vote classifier using natural language processing techniques and various machine learning algorithms.
GUIDANCE2: accurate detection of unreliable alignment regions accounting for the uncertainty of multiple parameters

Inference of multiple sequence alignments (MSAs) is a critical part of phylogenetic and comparative genomics studies. However, from the same set of sequences different MSAs are often inferred, depending on the methodologies used and the assumed parameters. Much effort has recently been devoted to improving the ability to identify unreliable alignment regions. Detecting such unreliable regions was previously shown to be important for downstream analyses relying on MSAs, such as the detection of positive selection. Here we developed GUIDANCE2, a new integrative methodology that accounts for: (i) uncertainty in the process of indel formation, (ii) uncertainty in the assumed guide tree and (iii) co-optimal solutions in the pairwise alignments, used as building blocks in progressive alignment algorithms. We compared GUIDANCE2 with seven methodologies to detect unreliable MSA regions using extensive simulations and empirical benchmarks. We show that GUIDANCE2 outperforms all previously developed methodologies. Furthermore, GUIDANCE2 also provides a set of alternative MSAs which can be useful for downstream analyses. The novel algorithm is implemented as a web-server, available at: http://guidance.tau. ac.il.
A Comparative Analysis of Industrial Escherichia coli K–12 and B Strains in High-Glucose Batch Cultivations on Process-, Transcriptome- and Proteome Level

Escherichia coli K–12 and B strains are among the most frequently used bacterial hosts for production of recombinant proteins on an industrial scale. To improve existing processes and to accelerate bioprocess development, we performed a detailed host analysis. We investigated the different behaviors of the E. coli production strains BL21, RV308, and HMS174 in response to high-glucose concentrations. Tightly controlled cultivations were conducted under defined environmental conditions for the in-depth analysis of physiological behavior. In addition to acquisition of standard process parameters, we also used DNA microarray analysis and differential gel electrophoresis (EttanTM DIGE). Batch cultivations showed different yields of the distinct strains for cell dry mass and growth rate, which were highest for BL21. In addition, production of acetate, triggered by excess glucose supply, was much higher for the K–12 strains compared to the B strain. Analysis of transcriptome data showed significant alteration in 347 of 3882 genes common among all three hosts. These differentially expressed genes included, for example, those involved in transport, iron acquisition, and motility. The investigation of proteome patterns additionally revealed a high number of differentially expressed proteins among the investigated hosts. The subsequently selected 38 spots included proteins involved in transport and motility. The results of this comprehensive analysis delivered a full genomic picture of the three investigated strains. Differentially expressed groups for targeted host modification were identified like glucose transport or iron acquisition, enabling potential optimization of strains to improve yield and process quality. Dissimilar growth profiles of the strains confirm different genotypes. Furthermore, distinct transcriptome patterns support differential regulation at the genome level. The identified proteins showed high agreement with the transcriptome data and suggest similar regulation within a host at both levels for the identified groups. Such host attributes need to be considered in future process design and operation.
Definition of the Instantaneous Frequency of an Electroencephalogram Using the Hilbert Transform

Application of methods of signal processing used in radioengineering for electroencephalograms (EEG) provides to increase the information content of the analysis and medical diagnostic quality. In this paper the method of EEG analysis based on the Hilbert transform are considered. Comparing results analysis with the Fourier transform (FT) and wavelet transform (WT) is carried out. Using the Hilbert transform for calculations, the analysis data on the informative parameters of EEG of healthy persons and those of epileptic patients were obtained. The calculated time dependences of the total phase and instantaneous frequency are presented on the diagrams. It is shown that application of the Hilbert transform provides an evident and simple interpretation of EEG diagnostics results. The phase-frequency method of EEG analysis gives an opportunity to track the dynamics of EEG change, to numerically characterize the duration and variation of the basic physiological rhythms, and, also, to observe the frequency change in time within the limits of each rhythm.
Hepatoprotective Potential of Some Local Medicinal Plants against 2-Acetylaminoflourene-Induced Damage in Rat

The in vivo micronucleus assay was used to examine the anticlastogenic effects of crude extracts of Bridelia ferruginea, Vernonia amygdalina, Tridax procumbens, Ocimum gratissimum, and Lawsonia inermis in Wistar albino rats. Extracts of doses of 100 mg/kg body weight were given to rats in five groups for seven consecutive days followed by a single dose of 2-AAF (0.5 mmol/kg body weight). The rats were sacrificed after 24 hours and their bone marrow smears were prepared on glass slides stained with Giemsa. The micronucleated polychromatic erythrocyte cells (mPCEs) were thereafter recorded. The hepatoprotective effects of the plant extracts against 2-AAF-induced liver toxicity in rats were evaluated by monitoring the levels of alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and histopathological analysis. The results of the 2-AAF-induced liver toxicity experiments showed that rats treated with the plant extracts (100 mg/kg) showed a significant decrease in mPCEs as compared with the positive control. The rats treated with the plant extracts did not show any significant change in the concentration of ALP and GGT in comparison with the negative control group whereas the 2-AAF group showed a significant increase (P < 0.05) in these parameters. Some of the leaf extracts also showed protective effects against histopathological alterations. This study suggests that the leaf extracts have hepatoprotective potential, thereby justifying their ethnopharmacological uses.
The Typology of Unknown Words: An Experimental Study of Two Corpora

Most current state-of-the-art natural language processing (NLP) systems, when presented with real-life texts, have problems recognizing each and every word present in the input. Depending on the application, the consequences can be severe. For example, in a machine translation system the quality of the processing may suffer and sometimes further processing may even be impossible.There are two main reasons why a word might not be recograzed and thus be considered unknown by the system:
A New Realistic Evaluation Analysis Method

In attempting to use a realistic evaluation approach to explore the role of Community Parents in early parenting programs in Toronto, a novel technique was developed to analyze the links between contexts (C), mechanisms (M) and outcomes (O) directly from experienced practitioner interviews. Rather than coding the interviews into themes in terms of context, intervention elements (mechanisms) and outcomes separately and which could be assembled into CMO configurations by the analyst, they were coded as linked dyads and triads directly from the practitioner narratives. Out of all of the linked codes entered, there were a maximum of three with the same combination, presenting challenges for typical qualitative data analysis. This article examines a novel technique that was developed in an attempt to expand this method beyond the circumstances described in the realistic evaluation literature to date. The bulk of the article focuses on the linked coding and analysis procedures, the challenges faced, and the original solutions that were developed to analyze the CMO relations and generate the mid-range theories necessary to move to the next stage of a realist evaluation approach. The features that distinguish this linked coding method from other methods (e.g. Qualitative Comparative Analysis), the major benefits and drawbacks, the utility of the approach within evaluation practice, and its application to realist synthesis and research are discussed.
Discovery of Two T Dwarf Companions with the Spitzer Space Telescope

We report the discovery of T dwarf companions to the nearby stars HN Peg (G0 V, 18.4 pc, τ ~ 0.3 Gyr) and HD 3651 (K0 V, 11.1 pc, τ ~ 7 Gyr). During an ongoing survey of 5′ × 5′ fields surrounding stars in the solar neighborhood with the Infrared Array Camera aboard the Spitzer Space Telescope, we identified these companions as candidate T dwarfs based on their mid-infrared colors. Using near-infrared spectra obtained with SpeX at the NASA Infrared Telescope Facility, we confirm the presence of methane absorption that characterizes T dwarfs and measure spectral types of T2.5 ± 0.5 and T7.5 ± 0.5 for HN Peg B and HD 3651B, respectively. By comparing our Spitzer data to images from the Two Micron All Sky Survey obtained several years earlier, we find that the proper motions of HN Peg B and HD 3651B are consistent with those of the primaries, confirming their companionship. A comparison of their luminosities to the values predicted by theoretical evolutionary models implies masses of 0.021 ± 0.009 and 0.051 ± 0.014 M☉ for HN Peg B and HD 3651B, respectively. In addition, the models imply an effective temperature for HN Peg B that is significantly lower than the values derived for other T dwarfs at similar spectral types, which is the same behavior reported by Metchev & Hillenbrand for the young late L dwarf HD 203030B. Thus, the temperature of the L/T transition appears to depend on surface gravity. Meanwhile, HD 3651B is the first substellar companion directly imaged around a star that is known to harbor a close-in planet from radial velocity surveys. The discovery of this companion supports the notion that the high eccentricities of close-in planets like that near HD 3651 may be the result of perturbations by low-mass companions at wide separations.
Sensory Anatomy and Sensory Ecology of Vintana Sertichi (Mammalia, Gondwanatheria) from the Late Cretaceous of Madagascar

ABSTRACT—Living mammals are distinguished from other extant tetrapods by adaptations for improved senses of hearing, touch, and smell. These adaptations, and concomitant reductions in visual anatomy, evolved during the Mesozoic in the mammalian and therian stem lineages. Here, we present a comparative study of the sensory anatomy of the Late Cretaceous gondwanatherian mammaliaform Vintana sertichi in order to draw inferences regarding its sensory abilities and sensory ecology. Our analyses demonstrate that Vintana has relatively large orbits that may have accommodated large eyes. Vintana also possessed cochlear primary and secondary osseous laminae and a cochlear canal that was relatively longer than in non-mammaliaform cynodonts but shorter than in extant therians. These features suggest that Vintana had some capacity for high-frequency hearing (i.e., >20 kHz), but that its cochlea may have encoded a more limited range of frequencies than the cochleas of most extant therians. The semicircular canals of Vintana have large radii of curvature and are nearly orthogonal, suggesting high sensitivity to angular head accelerations. These vestibular features may have evolved in order to stabilize large eyes during rapid and/or agile locomotion. Combined with evidence for large olfactory bulbs and a large trigeminal endocast, these data reveal that Vintana possessed a unique suite of sensory adaptations that distinguish it from other Mesozoic mammaliaforms. If these inferences are correct, then Vintana was probably a large-eyed and agile species, with a keen sense of smell and better high-frequency hearing than most other Mesozoic mammaliaforms. SUPPLEMENTAL DATA—Supplemental materials are available for this article for free at www.tandfonline. com/UJVP
Mediterranean Diet: Prevention of Colorectal Cancer

Colorectal cancer (CRC) is the third most common cancer diagnosis and the second and third leading cause of cancer mortality in men and women, respectively. However, the majority of CRC cases are the result of sporadic tumorigenesis via the adenoma–carcinoma sequence. This process can take up to 20 years, suggesting an important window of opportunity exists for prevention such as switching toward healthier dietary patterns. The Mediterranean diet (MD) is a dietary pattern associated with various health benefits including protection against cardiovascular disease, diabetes, obesity, and various cancers. In this article, we review publications available in the PubMed database within the last 10 years that report on the impact of a MD eating pattern on prevention of CRC. To assist the reader with interpretation of the results and discussion, we first introduce indexes and scoring systems commonly used to experimentally determine adherence to a MD, followed by a brief introduction of the influence of the MD pattern on inflammatory bowel disease, which predisposes to CRC. Finally, we discuss key biological mechanisms through which specific bioactive food components commonly present in the MD are proposed to prevent or delay the development of CRC. We close with a discussion of future research frontiers in CRC prevention with particular reference to the role of epigenetic mechanisms and microbiome related to the MD eating pattern.
Control Strategy for Echinococcus multilocularis

Echinococcus multilocularis, the causative agent of zoonotic alveolar echinococcosis, can be controlled effectively by the experimental delivery of anthelminthic baits for urban foxes. Monthly baiting over a 45-month period was effective for long-lasting control. Trimonthly baiting intervals were far less effective and did not prevent parasite recovery.
The Economics of Organizational Ideology

sources. First, a basically economistic approach to social theory has tended recurrently to guide conceptualization, research, and policy in socialist countries professed to various forms of workers’ participation.2 2 Economistic approaches to social theory rest on assumptions that organizations designed primarily to promote social and cultural aims may be treated within the same conceptual frameworks as economic organizations, and implicit premises that values of productivity and economic efficiency are preeminent and thus lie beyond the scope of critical inquiry and reflection. Social policy rests on a
Forgive & Forget? Attitudes Towards Forgiveness in the Case of Multiple, Similar Offenses

New research has emerged detailing the potential risks of forgiveness for couples as well as its benefits (McNulty, 2008, 2010, & 2011). Given the lack of research conducted on the perspective of the offending partner within the forgiveness process, this mixed method study examines the couple’s experience of the forgiveness and reconciliation process in the face of multiple, similar offenses. Though no support was found for the risks of forgiveness as proposed by McNulty (2011), factors that influenced the satisfaction of couples and the forgiveness process include self esteem, attachment, and spirituality. These factors, as well as the results from the qualitative interviews regarding inter-partner forgiveness, are
Therapeutic effect of hybrid training of voluntary and electrical muscle contractions in middle-aged obese women with nonalcoholic fatty liver disease: a pilot trial

Background Exercise training is an effective therapy for nonalcoholic fatty liver disease (NAFLD). Hybrid training (HYB) of voluntary and electrical muscle contractions was developed to prevent disuse atrophy during space flight. HYB can be applied to obtain a strength training effect accompanying articular movement. In this pilot study, we aimed to investigate the therapeutic efficacy of HYB in NAFLD. Methods A total of 15 middle-aged obese women with NAFLD who had no improvement in serum alanine aminotransferase levels and/or liver fat deposition after 12 weeks of lifestyle counseling participated in an HYB program. HYB of the quadriceps and hamstrings was conducted for 20 minutes twice a week for 24 weeks. Results NAFLD patients showed attenuated intramyocellular lipid levels in the quadriceps after the HYB intervention (−15.5%). Levels of leptin (−17.4%), tumor necrosis factor-α (−23.2%), and interleukin-6 (−30.5%) were also decreased after the intervention. HYB led to a significant body weight reduction (−4.7%), which in turn was associated with a significant decrease in serum alanine aminotransferase (−35.8%), gamma-glutamyl transpeptidase (−21.6%), ferritin (−16.0%), oxidative stress (−17.8%) levels, and insulin resistance values (−2.7%). Conclusion In NAFLD, HYB exerts an antiobesity effect and attenuates liver dysfunction and insulin resistance in association with an increase in muscle strength and a decrease in ectopic muscle fat. Therefore, HYB has great potential as a new type of exercise therapy for liver disease in patients with NAFLD.
Perceptions and Memories of the Free School Meal in Sweden

Abstract The aim of the present article was to gain a deeper understanding of the free school meal as an embedded phenomenon in the Swedish culture. This was achieved by studying perceptions and memories of the Swedish school meal. One hundred and ninety-two informants took part in the study by responding to an ethnological questionnaire. The results showed that the school meal was seen as a second-class meal with regard to the staff, environment and to some extent the food. The school meal was also seen as part of the Swedish welfare state, as it represents universal and equal social benefits for everyone. One interpretation of this is that the informants liked the idea of having a free public school meal, but that the meal does not live up to their expectations, that is, a meal with the same values as one served at home.
Power and Organizational Transformation through Technology: Hybrids of Electronic Government

This paper considers the UK Government's major modernization programme for local government and its aim to use technology to bring about a radical transformation in the delivery of public services by joining up hitherto separate service departments and focusing the organization of services around the citizen. Drawing upon empirical fieldwork in the North of England, the paper seeks to shed light on the realization and operation of modernization and considers the issues of power and hybridity involved in the emplacement of new organizational configurations (`front office' contact centres and `back office' service departments) to handle citizen inquiries.
The syntax of English genitive constructions

As is well known, English has two genitive or possessive constructions, the ‘proposed’ and the ‘postposed’, exemplified in (1). In each case we have an NP, with a head N (book, office, dog, house, plants) modified by a possessive expression (John's, a man's, mine, etc.). This expression is itself an NP in the genitive Case, and I shall refer to it as the ‘genitive phrase’. By contrast with other familiar languages more highly inflected than English, genitive Case is hot marked by an inflection on the head of a genitive phrase, but by the clitic ’s, which is attached right at the end of the phrase. The exception is where the genitive phrase is not a full NP but a personal pronoun, in which case we get an inflected form (irregular in pattern) as in these other languages: I - my/mine, he - his, etc. These possessive forms of pronouns have almost identical distribution to that of full NPs in the genitive (there are some differences which I shall point to below), and so it seems clear that they are genitives, despite the morphological difference; personal pronouns are highly irregular morphologically anyway, and not only in English. This is assumed in all recent work I know of, and I shall take it to be uncontroversial.