Miracle-dz/UniFAR-FTUs huggingface dataset:
Social Mobility and Perceived Discrimination: Adding an Intergenerational Perspective

This article adds an intergenerational perspective to the study of perceived ethnic discrimination. It proposes the conjecture that perceived discrimination tends to increase with parental education, particularly among those children of immigrants who have attained only mediocre levels of education themselves. I discuss that this conjecture may be developed as an argument that comes in two versions: a narrow version about explicit downward (intergenerational) mobility and a wide version about unfulfilled mobility aspirations more generally. Analyses based on the six-country comparative EURISLAM survey support the argument: parental education positively predicts perceived discrimination in general, but among the less educated this relation is most pronounced whereas it is absent among those with tertiary education. A replication and falsification test based on the German IAB-SOEP Migration Sample reconfirms the main finding and provides further original pieces of evidence. The analyses suggest processes associated with unfulfilled mobility aspirations as the more plausible underlying reason.
Unconditional Asset Pricing When Betas Covary with the Riskless Rate

I show that the relevant component of beta-dynamics that influences average returns implied by any conditional asset pricing model is the component that covaries with riskless rate fluctuations. These fluctuations are sufficient to measure the asymptotic effect of conditioning information on average returns because they mirror changes in the pivotal conditioning variable: the representative investor’s expected IMRS. Implementing my riskless rate representation for average returns implied by the conditional CAPM, ICAPM, and APT, I find a remarkable improvement. For example, in striking contrast to extant evidence, the conditional CAPM explains 64% of the cross section of returns for 25 size and value portfolios and 62% for 175 anomaly-based test portfolios.
Challenges, Benefits and Best Practices of Performance Focused DevOps

Did you know that just a handful of root causes are responsible for the majority of application issues like crashes, slow performance or incorrect application behavior? Non-optimized database access, deployment mistakes, memory leaks, or inefficient coding are just some examples. Companies that think Continuous Delivery and DevOps will solve all their problems typically fail as they just run into these problems faster. In this session we take a closer look at the most common problems, how to detect them and how to incorporate performance into your DevOps culture by automatically detecting these top problems.
Can Photoperiod Predict Mortality in the 1918-1920 Influenza Pandemic?

Amplitude of the seasonal change in day length increases with distance from the equator, and changes in day length markedly alter immune function in diverse nonhuman animal models of infection. Historical records of mortality data, ambient temperature, population density, geography, and economic indicators from 42 countries during 1918-1920 were analyzed to determine relative contributions toward human mortality during the “Spanish” influenza pandemic of 1918-1920. The data identify a strong negative relation between distance from the equator and mortality during the 1918-1920 influenza pandemic, which, in a multiple regression model, manifested independent of major economic, demographic, and temperature variables. Enhanced survival was evident in populations that experienced a winter nadir day length ≤10 h light/day, relative to those that experienced lower amplitude changes in photoperiod. Numerous reports indicate that exposure to short day lengths, typical of those occurring outside the tropics during winter, yields robust and enduring reductions in the magnitude of cytokine, febrile, and behavioral responses to infection. The present results are preliminary but prompt the conjecture that, if similar mechanisms are operant in humans, then they would be predicted to mitigate symptoms of infection in proportion to an individual’s distance from the equator. Although limitations and uncertainties accompany regression-based analyses of historical epidemiological data, latitude, per se, may be an underrecognized factor in mortality during the 1918-1920 influenza pandemic. The author proposes that some proportion of the global variance in morbidity and mortality from infectious diseases may be explained by effects of day length on the innate immune response to infection.
A study of phase noise in colpitts and LC-tank CMOS oscillators

This paper presents a study of phase noise in CMOS Colpitts and LC-tank oscillators. Closed-form symbolic formulas for the 1/f/sup 2/ phase-noise region are derived for both the Colpitts oscillator (either single-ended or differential) and the LC-tank oscillator, yielding highly accurate results under very general assumptions. A comparison between the differential Colpitts and the LC-tank oscillator is also carried out, which shows that the latter is capable of a 2-dB lower phase-noise figure-of-merit (FoM) when simplified oscillator designs and ideal MOS models are adopted. Several prototypes of both Colpitts and LC-tank oscillators have been implemented in a 0.35-/spl mu/m CMOS process. The best performance of the LC-tank oscillators shows a phase noise of -142dBc/Hz at 3-MHz offset frequency from a 2.9-GHz carrier with a 16-mW power consumption, resulting in an excellent FoM of /spl sim/189 dBc/Hz. For the same oscillation frequency, the FoM displayed by the differential Colpitts oscillators is /spl sim/5 dB lower.
The nucleotide sequence of phenylalanine tRNA from the cytoplasm of Neurospora crassa.

The phenylalanine tRNA from the cytoplasm of Neurospora crassa has been purified and sequenced. The sequence is: pGCGGGUUUAm2GCUCA (N) GDDGGGAGAGCm22GpsiCAGACmUGmAAYApsim5CUGAAGm7GDm5CGUGUGTpsiCGm1AUCCACACAAACCGCACCAOH. Both in the nature of modified nucleotides which are present in this tRNA and in the overall sequence, this tRNA resembles more closely phenylalanine tRNAs of eukaryotic cytoplasm than those of prokaryotes. The sequence of this tRNA differs from those of the corresponding tRNAs of wheat germ and yeast by only 6 and 7 nucleotides respectively out of 76 nucleotides.U
Undergraduate Students’ Perceptions of the Impact of Pre-College Computing Activities on Choices of Major

A lack of diversity in the computing field has existed for several decades, and although female participation in computing remains low, outreach programs attempting to address the situation are now quite numerous. To begin to understand whether or not these past activities have had long-term impact, we conducted a systematic literature review. Upon discovering that longitudinal studies were lacking, we investigated whether undergraduate students believed that their participation in computing activities prior to college contributed to their decision to major in a computing field. From the 770 participants in the study, we discovered that approximately 20% of males and 24% of females who were required to participate in computing activities chose a computing or related major, but that males perceived that the activity had a greater affect on their decision (20%) than females (6.9%). Females who participated in an outreach activity were more likely to major in computing. Compared with females who chose to major in computing, females who did not were less likely to indicate that the majority of students participating in activities were boys and that they were a welcome part of the groups. Results also showed that female participants who do not ultimately major in computing have a much stronger negative perception of the outreach activities than male participants who also chose a non-computing major. Although many computing outreach activities are designed to diversify computing, it may be the case that, overall, boys receive these activities more favorably than girls, although requiring participation yields approximately the same net positive impact.
Innovations in workplace accessibility and accommodation for persons with hearing loss: using social networking and community of practice theory to promote knowledge exchange and change.

BACKGROUND Despite widespread availability of assistive technology and the role of occupational therapists and audiologists in workplace health, little is known about how these groups influence the health of workers with hearing loss. OBJECTIVE Based on a previously conducted study, this paper explores the need for networking and community of practice theory to promote knowledge sharing and use between occupational therapists, audiologists, educators, regulators, workers, and employers. METHODS Five occupational therapists and five audiologists participated in in-depth interviews. Grounded theory was used to investigate the processes that hinder or support these professionals in addressing the accommodation needs of and workplace accessibility for workers with hearing loss. RESULTS Constraints to addressing the needs of workers with hearing loss included: lack of knowledge about professional practice processes, lack of networking, lack of knowledge on current research, and lack of knowledge on the realm of expertise of audiologists by occupational therapists and of occupational therapists by audiologists. CONCLUSIONS Innovations in workplace practice in hearing loss require engagement of occupational therapists, audiologists, and employers in knowledge transfer, networking, and learning. This column introduces two theories that may guide the use and development of evidence, knowledge, and expertise toward innovations in hearing work practice.
Cisplatin Sensitizes Cancer Cells to Ionizing Radiation via Inhibition of Nonhomologous End Joining

The combination of cisplatin and ionizing radiation (IR) treatment represents a common modality for treating a variety of cancers. These two agents provide considerable synergy during treatment, although the mechanism of this synergy remains largely undefined. We have investigated the mechanism of cisplatin sensitization to IR using a combination of in vitro and in vivo experiments. A clear synergistic interaction between cisplatin and IR is observed in cells proficient in nonhomologous end joining (NHEJ) catalyzed repair of DNA double-strand breaks (DSB). In contrast, no interaction between cisplatin and IR is observed in NHEJ-deficient cells. Reconstituted in vitro NHEJ assays revealed that a site-specific cisplatin-DNA lesion near the terminus results in complete abrogation of NHEJ catalyzed repair of the DSB. These data show that the cisplatin-IR synergistic interaction requires the DNA-dependent protein kinase–dependent NHEJ pathway for joining of DNA DSBs, and the presence of a cisplatin lesion on the DNA blocks this pathway. In the absence of a functional NHEJ pathway, although the cells are hypersensitive to IR, there is no synergistic interaction with cisplatin.
Effect of input data variability on estimations of the equivalent constant temperature time for microbial inactivation by HTST and retort thermal processing.

UNLABELLED Consumer demand for food safety and quality improvements, combined with new regulations, requires determining the processor's confidence level that processes lowering safety risks while retaining quality will meet consumer expectations and regulatory requirements. Monte Carlo calculation procedures incorporate input data variability to obtain the statistical distribution of the output of prediction models. This advantage was used to analyze the survival risk of Mycobacterium avium subspecies paratuberculosis (M. paratuberculosis) and Clostridium botulinum spores in high-temperature short-time (HTST) milk and canned mushrooms, respectively. The results showed an estimated 68.4% probability that the 15 sec HTST process would not achieve at least 5 decimal reductions in M. paratuberculosis counts. Although estimates of the raw milk load of this pathogen are not available to estimate the probability of finding it in pasteurized milk, the wide range of the estimated decimal reductions, reflecting the variability of the experimental data available, should be a concern to dairy processors. Knowledge of the C. botulinum initial load and decimal thermal time variability was used to estimate an 8.5 min thermal process time at 110 °C for canned mushrooms reducing the risk to 10⁻⁹ spores/container with a 95% confidence. This value was substantially higher than the one estimated using average values (6.0 min) with an unacceptable 68.6% probability of missing the desired processing objective. Finally, the benefit of reducing the variability in initial load and decimal thermal time was confirmed, achieving a 26.3% reduction in processing time when standard deviation values were lowered by 90%. PRACTICAL APPLICATION In spite of novel technologies, commercialized or under development, thermal processing continues to be the most reliable and cost-effective alternative to deliver safe foods. However, the severity of the process should be assessed to avoid under- and over-processing and determine opportunities for improvement. This should include a systematic approach to consider variability in the parameters for the models used by food process engineers when designing a thermal process. The Monte Carlo procedure here presented is a tool to facilitate this task for the determination of process time at a constant lethal temperature.
The Bank Lending Channel A Time-Varying Approach

Using a cross-country panel of 925 banks from 19 advanced economies, for the period 1981-2016, I examine how the bank lending channel of monetary policy has evolved over time. I find that the sensitivity of lending to bank balance sheet liquidity declines over time, with nearly all the reduction occurring between the early 1990s and the early 2000s. Contrary to normal times, during recessions, more liquid banks reinforce the impact of monetary policy shocks on lending relative to their less liquid counterparts. The sensitivity of non-interest income to lending increases sharply from the late 1990s till the global financial crisis of 2008, and declines in the post-crisis period, indicating pro-cyclicality. Moreover, the relative ability of banks with higher non-interest income to mitigate monetary policy shocks increases sharply towards the end of the sample period, capturing the impact of the prolonged low interest rate environment on transmission process. These findings suggest that the structural changes in the banking industry and the state of the economy have a significant impact on the strength of the bank lending channel.
Managers’ Corruption Prevention Efforts in Small and Medium‐Sized Enterprises: An Exploration of Determinants

Based on an extension of the theory of planned behavior, this paper examines the determinants of managers&#8217; corruption prevention efforts in small and medium&#8208;sized enterprises (SMEs). For this, we collected survey data from 339 managers in German SMEs and conducted five supplementary in&#8208;depth interviews. Our quantitative findings show that the SMEs&#8217; managers&#8217; moral obligation, subjective norm, self&#8208;efficacy, perceived controllability, and perceived threat of employees&#8217; corrupt behavior are positively related to managers&#8217; intention to apply corruption prevention measures in their SME. This intention in turn is positively related to the application of such measures as is the managers&#8217; perceived controllability. The supplementary qualitative analysis mostly supports these results. Based on our findings, we identify starting points to reach a higher sensitization of managers in SMEs to corruption prevention.
Employment of methylene blue irradiated with laser light source in photodynamic inactivation of biofilm formed by Candida albicans strain resistant to fluconazole

Abstract A promising approach for the eradication of biofilm formed by the yeast Candida albicans seems to be photodynamic inactivation (PDI). This work presents a use of methylene blue (MB, 1 mM) irradiated with a red laser (output power 190 mW/cm2, wavelength 660 nm) for the eradication of a biofilm formed by the fluconazole‐resistant (FLC‐resistant) strain C. albicans CY 1123 compared to the standard strain C. albicans SC5314. The periods of irradiation corresponded to the fluence of 15, 23 and 57 J/cm2. Effectiveness of PDI was evident with following percentage of survived biofilm cells: 24.57, 23.46, and 22.29% for SC5314 and 40.28, 17.91, and 5.89% for CY 1123, respectively, compared to the samples without irradiation. Light and confocal laser scanning microscopy confirmed the effectiveness of PDI. However, the morphological form of C. albicans seems to play an important role as well, since prolonged duration of irradiation did not increase efficiency of PDI on C. albicans SC5314. An experiment with the yeast‐to‐hyphae transition revealed that the FLC‐resistant strain expressed a markedly reduced capacity to form hyphae compared to SC5314. We summarized that PDI was effective on biofilm formed by the FLC‐resistant strain, but resistance most likely did not play significant role in PDI. Additionally, we observed differences in susceptibility to PDI between biofilms composed of the mycelia and only of the yeasts, and finally, the employment of a laser in PDI enabled a decreasing period of irradiation while maintaining the high effectiveness of PDI.
A location algorithm based on radio propagation modeling for indoor wireless local area networks

This paper presents a location algorithm for indoor wireless local area networks (LANs) that is based on the signal-to-noise ratio (SNR) and a radio propagation model. The proposed radio propagation modeling approach reduces the number of training data points with no significant degradation in the location accuracy, as compared to the conventional empirical method. Experimental results obtained from an indoor wireless LAN are given to demonstrate its effectiveness.
Wnt Pathway Regulation in Chronic Renal Allograft Damage

The Wnt signaling pathway, linked to development, has been proposed to be recapitulated during the progressive damage associated with chronic organ failure. Chronic allograft damage following kidney transplantation is characterized by progressive fibrosis and a smoldering inflammatory infiltrate. A modified, Fischer 344 (RT1lvl) to Lewis (RT1l) rat renal allograft model that reiterates many of the major pathophysiologic processes seen in patients with chronic allograft failure was used to study the progressive disease phenotype and specific gene product expression by immunohistochemistry and transcriptomic profiling. Central components of the Tgfb, canonical Wnt and Wnt‐Ca2+ signaling pathways were significantly altered with the development of chronic damage. In the canonical Wnt pathway, Wnt3, Lef1 and Tcf1 showed differential regulation. Target genes Fn1, Cd44, Mmp7 and Nos2 were upregulated and associated with the progression of renal damage. Changes in the Wnt‐Ca2+ pathway were evidenced by increased expression of Wnt6, Wnt7a, protein kinase C, Cam Kinase II and Nfat transcription factors and the target gene vimentin. No evidence for alterations in the Wnt planar cell polarity (PCP) pathway was detected. Overall results suggest cross talk between the Wnt and Tgfb signaling pathways during allograft inflammatory damage and present potential targets for therapeutic intervention.
Altered dose‐to‐effect of propofol due to pharmacokinetics in rats with experimental diabetes mellitus

Pathology related alterations in the pharmacokinetics or the pharmacodynamics of propofol could contribute to the observed large variability in the hypnotic dose. We have tested the influence of diabetes mellitus on the induction dose and the pharmacokinetics and pharmacodynamics of propofol in rats. Diabetes was induced in rats by administration of streptozotocin (60 mg kg−1, i.p.) while control rats received vehicle intraperitoneally. All animals had glucose, cholesterol, triglycerides and albumin levels measured. In‐vitro protein binding was determined by ultrafiltration. Rats were randomly split into set 1 (dose‐concentration‐effect study) with control and streptozotocin rats, and set 2 (pharmacokinetic study), with control and streptozotocin rats. Rats in the effect set received either a variable infusion of 6 mg kg−1 min−1 propofol until onset (induction dose) of the hypnotic effect (loss of the righting reflex), or a 15 mg kg−1 bolus to assess offset time (recovery of the righting reflex). Blood (Cblood) and brain (Cbrain) propofol concentrations at onset and offset were assayed by HPLC. In the pharmacokinetic study, propofol was administered intravenously at 6 mg kg−1 min−1 for 2 min. Arterial blood samples were collected between 0.5 and 540 min and assayed for propofol. A mixed effects compartmental pharmacokinetic modelling method (NONMEM) was used to analyse the observations and variabilities. The dose necessary for onset differed between streptozotocin and controls, and so did the pharmacokinetics with two‐ and three‐compartment descriptions, respectively. Cblood and Cbrain at onset and offset were similar, possibly rejecting changes in pharmacodynamics. The total and unbound volume of distribution was significantly lower in the streptozotocin group with no differences in clearance (CL) between streptozotocin and controls, (mean (inter‐animal CV%)) CL = 0.026 (17%) and 0.025 (62%) L min−1, respectively. Individual Bayes Vdss (volume of distribution at steady state) were different, (mean (s.d.)) Vdss = 7.7 (2.67) and 1.11 (0.09) L, respectively. The pharmacokinetic model was validated by comparison with the data from set 1. Simulations of total and unbound Cblood, for both groups, at the hypnotic dose for the controls, revealed differences throughout the time course of the pharmacokinetics. The difference observed in the induction dose of propofol to streptozotocin and control rats was due to alterations in the pharmacokinetics, secondary to the pathology.