Miracle-dz/UniFAR-FTUs huggingface dataset:
Hierarchical bidirectional attention-based RNN in BioCreative VI precision medicine track, document triage task

In this paper, we describe our submission to the ”Document Triage Task”, of the BioCreative VI Precision Medicine Track, in which we ranked first among ten teams. The submitted system is a Hierarchical Bidirectional AttentionBased Recurrent Neural Network (RNN). Our approach utilizes the hierarchical nature of documents, which are composed of sequences of sentences, where sentences are composed of sequences of words. We propose a reusable sequence encoder architecture, which is used as sentence and document encoder. The sequence encoder, is composed of a bidirectional RNN, equipped with an attention mechanism, which identifies and captures the most important elements (words or sentences) in a sequence. Furthermore, we argue that the title of the paper itself, usually contains important information, compared to the other sentences of the abstract. For this reason, we propose a shortcut connection, which integrates the title’s vector representation, directly to the final feature representation of the document. We leverage word embeddings, trained on PubMed, for initializing the embedding layer of our network. Moreover, our system does not rely on handcrafted features. Furthermore, we train our system end-to-end using back-propagation, with stochastic gradient descent. We make the source code available to the research community. Keywords— Document Classification; Hierarchical Recurrent Neural Network; GRU; Attention Layer
Generation of High-Purity Millimeter-Wave Orbital Angular Momentum Modes Using Horn Antenna: Theory and Implementation

Twisted electromagnetic waves, of which the helical phase front is called orbital angular momentum (OAM), have been recently explored for quantum information, high speed communication and radar detections. In this context, generation of high purity waves carrying OAM is of great significance and challenge from low frequency band to optical area. Here, a novel strategy of mode combination method is proposed to generate twisted waves with arbitrary order of OAM index. The higher order mode of a circular horn antenna is used to generate the twisted waves with quite high purity. The proposed strategy is verified with theoretical analysis, numerical simulation and experiments. A circular horn antenna operating at millimeter wave band is designed, fabricated, and measured. Two twisted waves with OAM index of l=+1 and l=-1 with a mode purity as high as 87% are obtained. Compared with the other OAM antennas, the antenna proposed here owns a high antenna gain (over 12 dBi) and wide operating bandwidth (over 15%). The high mode purity, high antenna gain and wide operating band make the antenna suitable for the twisted-wave applications, not only in the microwave and millimeter wave band, but also in the terahertz band.
Photoabsorption spectra of small Na clusters: TDHF and BSE versus CI and experiment

Time-dependent Hartree-Fock (TDHF) and Bethe-Salpeter equation (BSE) methods are benchmarked against configuration interaction (CI) calculations of excitation energies and photoabsorption cross sections for small closed shell sodium clusters with up to six atoms in several low energy configurations. The mean absolute deviation of lowest excitation energies of each symmetry in these clusters for TDHF or BSE calculations from CI results is about 0.1 eV. The Thomas-Reiche-Kuhn (TRK) sum rule is satisfied to within numerical accuracy for both TDHF and BSE calculations, however, Tamm-Dancoff approximations applied to either method for these systems yield optical cross sections which grossly violate the TRK sum rule. TDHF and BSE calculations for photoabsorption cross sections of Na8 and Na20 clusters are compared to experiment and found to be in good agreement. A feature in the cross section of Na20 above 4 eV is found to be caused by a large density of optical transitions rather than an incipient volume plasmon with a short lifetime.
Channel estimation for TDS-OFDM-based DTTB systems in the presence of phase noise

As an effective technique for combating multipath fading and for high-bit-rate transmission over wireless channels, orthogonal frequency division multiplexing (OFDM) is extensively used in modern digital television terrestrial broadcasting (DTTB) systems to support high performance bandwidth-efficient multimedia services. In this paper, a robust channel estimation scheme is proposed for the time domain synchronous OFDM (TDS-OFDM) based DTTB systems in the presence of phase noise. Simulations under different channel situations verify the efficiency of the proposed scheme.
Does greater labour market freedom lead to lower new home prices in the US? An exploratory inquiry

ABSTRACT In this study for the year 2014 for the United States, we find that the median price of new single-family homes was an increasing function of the state’s median family income, the number of miles of coastline in the state and the state’s population density. In addition, the evidence suggests that the median new home price may been a decreasing function of the crime rate. Finally, of particular interest to this study, is the finding that a higher degree of labour market freedom led to lower prices on newly constructed single-family homes.
Comparative Proximate Compositions of Watermelon Citrullus Lanatus, Squash Cucurbita Pepo'l and Rambutan Nephelium Lappaceum

The nutritional quality/contents of the pulp, seeds and rind of Citrullus lanatus, Nephelium lappaceum and Cucurbita pepo’L were evaluated. The study was carried out on both fresh and dried samples. Results of the investigation reveal that the seeds of the fruits were all rich in oil, protein. Although there was a significant changes (p< 0.05) in the nutrient contents i.e protein, carbohydrate, crud fat, crud protein, moisture and ash content in the different parts of the fruits, the nutrients in the seeds and rind which are the parts always discarded, can contribute immensely to recommended daily allowance and maintenance of good nutritional status and hence good health for both man and livestock.
AGE, WORK, AND INCOME

The insecurities and vagaries of old age, intensified by unstable employment and recurrent poverty at earlier ages, made collective economic strategies imperative for the family unit. The functions of old people in the late nineteenth and early twentieth century can be better understood within the framework of the family economy. Work careers and family organization were clearly intertwined, and reciprocity among family members along the life course was essential for survival in old age. Exchanges across generations were critical for the survival of old people, particularly in the working class, as an intensifying industrial system was gradually ousting them from their jobs without providing public-welfare mechanisms for their support [14, 21].
Clinical Outcomes and Costs Due to Staphylococcus aureus Bacteremia Among Patients Receiving Long-Term Hemodialysis

Abstract Objective: To examine the clinical outcomes and costs associated with Staphylococcus aureus bacteremia among hemodialysis-dependent patients. Design: Prospectively identified cohort study. Setting: A tertiary-care university medical center in North Carolina. Patients: Two hundred ten hemodialysis-dependent adults with end-stage renal disease hospitalized with S. aureus bacteremia. Results: The majority of the patients (117; 55.7%) underwent dialysis via tunneled catheters, and 29.5% (62) underwent dialysis via synthetic arteriovenous fistulas. Vascular access was the suspected source of bacteremia in 185 patients (88.1%). Complications occurred in 31.0% (65), and the overall 12-week mortality rate was 19.0% (40). The mean cost of treating S. aureus bacteremia, including readmissions and outpatient costs, was $24,034 per episode. The mean initial hospitalization cost was significantly greater for patients with complicated versus uncomplicated S. aureus bacteremia ($32,462 vs $17,011; P= .002). Conclusion: Interventions to decrease the rate of S. aureus bacteremia are needed in this high-risk, hemodialysis-dependent population (Infect Control Hosp Epidemiol 2005;26:534-539).
Comparative study of two forms of aro A CP 4 gene in Escherichia coli

The enzyme CP4 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS; EC 2.5.1.19) from Agrobacterium tumefaciens CP4, encoded by the aroA gene, has been used for the construction of genetically modified crops resistant to total herbicide glyphosate. During the study of possible horizontal gene transfer of aroA CP4 gene from genetically modified food in gastrointestinal tract to bacterial community living in the animal gut, we have discovered and characterized truncated form of aroA CP4 within the cloning experiments in Escherichia coli. We have compared properties of the recombinant E. coli strains with both CP4 EPSPS enzyme forms.
Biodegradable-polymer-based, sirolimus-eluting Supralimus stent: 6-month angiographic and 30-month clinical follow-up results from the series I prospective study.

AIMS There have been recent concerns regarding the long-term safety of the first generation of drug-eluting stents, which utilised a permanent polymer coating for drug delivery. SERIES I is a prospective, non-randomised, first-in-man open label study with the biodegradable polymer-based Supralimus sirolimus eluting stent (Sahajanand Medical Technologies Pvt. Ltd, India) for the treatment of patients with coronary artery lesions. METHODS AND RESULTS One hundred patients were treated with 126 Supralimus stents (mean lesion length 10.5 +/- 4.3 mm, mean reference vessel diameter 2.66 +/- 0.62 mm). The pre-specified primary endpoint was angiographic binary in-stent restenosis at six months. Secondary endpoints were device-orientated major adverse clinical events (MACE; defined as a composite of cardiac death, nonfatal myocardial infarction [Q-wave and Non-Q wave], or clinically-justified target vessel revascularisation) at 30 days, nine months and 30 months. Angiographic follow-up in a pre-specified subgroup of 60 patients at six months showed binary angiographic restenosis rates of 0% (in-stent) and 1.7% (in-segment). The in-stent late loss was 0.09 +/- 0.37 mm. MACE rates were 0% after one month, 6% at 9-month follow-up and 7% after 30 months follow-up. CONCLUSIONS The biodegradable-polymer-based sirolimus-eluting stent (Supralimus) is effective in inhibiting neointimal hyperplasia.
Laboratory evaluation of the Ile1, 016 mutation-effect on several life-history parameters of Aedes aegypti

Pyrethroid insecticides were intensively applied in Mexico between 2000 and 2009. We evaluated the effect of the Ile1, 016 mutation on several life-history parameters of Ae. aegypti from Merida, Yucatan. Aedes aegypti colonies was established from larvae collected in houses between October and November 2015. Fifty adult females were analyzed for the frequency of the Ile1, 016 mutation at each collection site (n = 3). All biological parameters were evaluated by comparing the control group versus natural population of Ae. aegypti. The frequency of kdr homozygous (Val1, 016) was high in all sites studied, being 76% in Juan Pablo-II, 85% in Chuburna and 87% in Vergel-III. In Ae. aegypti with kdr homozygous were observed delay larval development, higher mortality in late stages, decrease in blood ingested and have a larger body sizes. Our results suggest that Ae. aegypti with kdr homozygous have a diminished reproductive fitness compared to susceptible group.
Gamifying Self-Management of Chronic Illnesses: A Mixed-Methods Study

Background Self-management of chronic illnesses is an ongoing issue in health care research. Gamification is a concept that arose in the field of computer science and has been borrowed by many other disciplines. It is perceived by many that gamification can improve the self-management experience of people with chronic illnesses. This paper discusses the validation of a framework (called The Wheel of Sukr) that was introduced to achieve this goal. Objective This research aims to (1) discuss a gamification framework targeting the self-management of chronic illnesses and (2) validate the framework by diabetic patients, medical professionals, and game experts. Methods A mixed-method approach was used to validate the framework. Expert interviews (N=8) were conducted in order to validate the themes of the framework. Additionally, diabetic participants completed a questionnaire (N=42) in order to measure their attitudes toward the themes of the framework. Results The results provide a validation of the framework. This indicates that gamification might improve the self-management of chronic illnesses, such as diabetes. Namely, the eight themes in the Wheel of Sukr (fun, esteem, socializing, self-management, self-representation, motivation, growth, sustainability) were perceived positively by 71% (30/42) of the participants with P value <. 001. Conclusions In this research, both the interviews and the questionnaire yielded positive results that validate the framework (The Wheel of Sukr). Generally, this study indicates an overall acceptance of the notion of gamification in the self-management of diabetes.
A High-Efficiency Switched-Capacitance HTFET Charge Pump for Low-Input-Voltage Applications

This paper presents a high-efficiency switched-capacitance charge pump in 20 nm III-V heterojunction tunnel field-effect transistor (HTFET) technology for low-input-voltage applications. The steep-slope and low-threshold HTFET device characteristics are utilized to extend the input voltage range to below 0.20 V. Meanwhile, the uni-directional current conduction is utilized to reduce the reverse energy loss and to simplify the non-overlapping phase controlling. Furthermore, with unidirectional current conduction, an improved cross-coupled charge pump topology is proposed for higher voltage output and PCE. Simulation results show that the proposed HTFET charge pump with a 1.0 kΩ resistive load achieves 90.4% and 91.4% power conversion efficiency, and 0.37 V and 0.57 V DC output voltage, when the input voltage is 0.20 V and 0.30 V, respectively.
Caspase Recruitment Domain Protein 6 Protects Against Hepatic Steatosis and Insulin Resistance by Suppressing Apoptosis Signal–Regulating Kinase 1

The rapidly increasing prevalence of metabolic disorders associated with nonalcoholic fatty liver disease (NAFLD) warrants further study of the underlying mechanisms to identify key regulators as targets for the development of therapeutic interventions. Caspase recruitment domain protein 6 (Card6), as a member of the CARD family that regulates cell death and immunity, may potentially control this process. Indeed, Card6 down‐regulation was found to be closely associated with the fatty livers observed in NAFLD patients, obese mice, and a palmitate‐treated hepatocyte model. Gain‐of‐function and loss‐of‐function Card6 mouse models demonstrated that Card6 protected mice from insulin resistance, hepatic steatosis, and inflammatory responses upon high‐fat diet administration. Mechanistically, Card6 interacted with and inhibited apoptosis signal–regulating kinase 1 (Ask1) and its subsequent downstream c‐Jun N‐terminal kinase/p38 signaling. Furthermore, Ask1 was sufficient to mediate Card6 function, and the interaction between Ask1 and Card6 was absolutely required for Card6 function in vivo. Adenovirus‐mediated Card6 overexpression in the liver effectively ameliorated insulin resistance and hepatic steatosis in ob/ob mice. Therefore, we identified Card6 as an important negative regulator in NAFLD. Conclusion: Targeting Ask1 by Card6 may be a good strategy to develop a therapeutic method against NAFLD.
Silencing and trans‐activation of the mouse IL‐2 gene in Xenopus oocytes by proteins from resting and mitogen‐induced primary T‐lymphocytes.

The Xenopus oocyte system was used to test functionally, putative trans‐active elements involved in the transcriptional control of the mouse interleukin‐2 (IL‐2) gene in resting and mitogen‐induced primary T‐lymphocytes. The IL‐2 gene injected into the oocyte is active over a wide range of DNA concentrations. This basal activity is silenced by the addition of protein extracts from G0‐arrested spleen cells. Extracts from 8 h‐stimulated spleen cells do not silence but moderately increase transcription over basal level. When IL‐2 transcription is silenced first by an injection of extract from resting spleen cells, the addition of proteins from stimulated cells results in a strong increase in transcription (derepression). Use of proteins from purified splenic T‐lymphocytes shows that both silencer(s) and activator(s) are contributed by these cells. Extracts from control tissues have neither a silencing nor stimulatory effect. None of the proteins tested affects the activities of co‐injected control genes. Injections with IL‐2 promoter mutants indicate that the main target sequence of the silencing and activating factors is a purine region (Pu‐box) lying between positions −261 and −292 upstream of the IL‐2 gene. Bandshift assays show differential binding of the Pu‐box with proteins from resting or activated T‐cells.
Qualitatively Informed Propositions for Teaching Research Methods to Aeronautical Science Students

Recent changes to Embry-Riddle Aeronautical University’s Master of Aeronautical Science program have been implemented with difficulty by the faculty who teach Research Methods, and the learning objectives have not easily translated into concepts quickly grasped by the students. In this qualitative, grounded theory study, I evaluated 126 comments from 196 Aeronautical Science students through an inductive approach to identify themes for improving the administration and execution of the Research Methods course. Positive and negative themes indicate that students seek clear expectations, examples, and feedback to improve understanding of these complex concepts. Four propositions are presented: infuse an inquiry-based learning approach using templates and examples, improve student readiness, present final project options, and sequence the program.
Topographic patterns of v2 cortical connections in a prosimian primate (Galago garnetti)

Topographic patterns of cortical connections of the second visual area (V2) were examined in a lorisiform prosimian primate (Galago garnetti). Up to five different tracers were injected into dorsal and ventral V2. Tracers included wheat germ agglutinin conjugated to horseradish peroxidase (WGA‐HRP) and up to four fluorochromes. Tracer injections consistently labeled neurons and terminals in primary visual cortex (V1), V2, the middle temporal area (MT), and the dorsolateral visual area (DL). Labeled neurons were also found in other proposed extrastriate areas such as the dorsomedial visual area (DM), dorsointermediate area (DI), middle temporal crescent (MTc), medial superior temporal area (MST), ventral posterior parietal area (VPP), and caudal inferotemporal cortex (ITc), but these connections were more variable and less dependent on the retinotopic position of injection sites in V2. Areal boundaries were identified by differences in cytochrome oxidase (CO) and myelin staining. We conclude that V2 cortical connections in prosimian galagos are similar to those in simian primates, suggesting that prosimians and other lines of primate evolution have retained several visual areas from a common ancestor that relate to V2 in similar ways. Architectural features of striate and extrastriate areas in prosimian galagos are similar to simian primates, with notable exceptions such as stripes in V2, which appear to be less differentiated in galagos. J. Comp. Neurol. 431:155–167, 2001. © 2001 Wiley‐Liss, Inc.
Reflex Testing Rules for Cell Count and Differentiation of Nucleated Elements in Pleural and Ascitic Fluids on Sysmex XE-5000

Flow cytometry is widely used in many laboratories for automated nucleated cell counts and their differentiation in body fluids. The implementation of new reflex testing rules on these automated instruments could open new frontiers in laboratory workflow, improving characterization of body fluids and clinical diagnosis and decreasing costs. Ascitic (150) and pleural (33) fluids were collected and assessed by XE-5000 and optical microscopy. Cell counts performed with the methods showed a Pearson’s correlation of 0.98 (p < 0.0001), Passing–Bablok regression y = 0.99x + 2.44, and bias of 32.3. In ascitic fluids, the best diagnostic performance was found for polymorphonuclear and neutrophil counts on XE-5000, which exhibited areas under the curve (AUCs) 0.98 (p < 0.0001) and 0.99 (p < 0.0001), respectively. In pleural fluids the best diagnostic performance was found for polymorphonuclear percent parameter, which displayed 0.97 (p < 0.0001). Specific reflex test rules based on these parameters were characterized by 92% diagnostic concordance, 1.00 sensitivity, and 0.84 specificity with optical microscopy. The application of a set of reflex testing rules may improve the diagnostic performance of XE-5000, increasing its reliability for routine automated cell count in body fluids. We acknowledge that further studies should be planned to validate our findings according to clinical data.
Efficacy and safety of dual therapy with daclatasvir and asunaprevir in elderly patients

AIM To survey the efficacy and safety of dual therapy with daclatasvir and asunaprevir in the elderly hepatitis C virus (HCV) patients multicentricity. METHODS Interferon-ineligible/intolerant patients and non-responders to previous pegylated-interferon/ribavirin therapy with chronic HCV genotype 1b infection were enrolled. Child B, C cirrhotic patients were excluded. Patients received oral direct acting antiviral treatment consisting of 60 mg daclatasvir once daily plus 200 mg asunaprevir twice daily for 24 wk. We divided the patients into two groups of 56 elderly patients (≥ 75 years-old) and 141 non-elderly patients (< 75 years old) and compared the efficacy and safety. RESULTS Ninety-one point one percent of elderly patients and 90.1% of non-elderly patients achieved sustained virological response at 24 wk (SVR24). In the former, 1.8% experienced viral breakthrough, as compared with 3.5% in the latter (not significant). Adverse events occurred in 55.4% of the former and 56.0% of the latter. In the former, 7 cases (12.5%) were discontinued due to adverse events, and in the latter 9 cases were discontinued (6.4%, not significant). CONCLUSION Dual therapy with daclatasvir and asunaprevir achieved the same high rates of SVR24 in HCV elderly patients without more adverse events than in the non-elderly patients.
3D Printed Bioreactor with Optimized Stimulations for Ex-Vivo Bone Tissue Culture

x CHAPTER 1: INTRODUCTION . 1 Ex-vivo Tissue Culture . 1 Bioreactors for Ex-vivo Bone Tissue Culture . 1 Limitations of Existing Systems . 2 Our Contribution . 3 CHAPTER 2: LITERATURE REVIEW . 5 Research Objective . 9 CHAPTER 3: METHOD AND APPROACH . 10 Device Development . 10 Bioreactor Fabrication . 11 Mechanical Loading System . 12 Sensor Calibration and Loading Profile . 14 Device Application for Ex-vivo Tissue Culture . 20 Sample Preparation . 21 Storage Conditions and Nutrient Media . 21 Tissue Analysis . 23