Miracle-dz/UniFAR-FTUs huggingface dataset:
The design of and chronic tissue response to a composite nerve electrode with patterned stiffness

Objective. As neural interfaces demonstrate success in chronic applications, a novel class of reshaping electrodes with patterned regions of stiffness will enable application to a widening range of anatomical locations. Patterning stiff regions and flexible regions of the electrode enables nerve reshaping while accommodating anatomical constraints of various implant locations ranging from peripheral nerves to spinal and autonomic plexi. Approach. Introduced is a new composite electrode enabling patterning of regions of various electrode mechanical properties. The initial demonstration of the composite’s capability is the composite flat interface nerve electrode (C-FINE). The C-FINE is constructed from a sandwich of patterned PEEK within layers of pliable silicone. The shape of the PEEK provides a desired pattern of stiffness: stiff across the width of the nerve to reshape the nerve, but flexible along its length to allow for bending with the nerve. This is particularly important in anatomical locations near joints or organs, and in constrained compartments. We tested pressure and volume design constraints in vitro to verify that the C-FINE can attain a safe cuff-to-nerve ratio (CNR) without impeding intraneural blood flow. We measured nerve function as well as nerve and axonal morphology following 3 month implantation of the C-FINE without wires on feline peripheral nerves in anatomically constrained areas near mobile joints and major blood vessels in both the hind and fore limbs. Main Results. In vitro inflation tests showed effective CNRs (1.93 ± 0.06) that exceeded the industry safety standard of 1.5 at an internal pressure of 20 mmHg. This is less than the 30 mmHg shown to induce loss of conduction or compromise blood flow. Implanted cats showed no changes in physiology or electrophysiology. Behavioral signs were normal suggesting healthy nerves. Motor nerve conduction velocity and compound motor action potential did not change significantly between implant and explant (p > 0.15 for all measures). Axonal density and myelin sheath thickness was not significantly different within the electrode compared to sections greater than 2 cm proximal to implanted cuffs (p > 0.14 for all measures). Significance. We present the design and verification of a novel nerve cuff electrode, the C-FINE. Laminar manufacturing processes allow C-FINE stiffness to be configured for specific applications. Here, the central region in the configuration tested is stiff to reshape or conform to the target nerve, while edges are highly flexible to bend along its length. The C-FINE occupies less volume than other NCEs, making it suitable for implantation in highly mobile locations near joints. Design constraints during simulated transient swelling were verified in vitro. Maintenance of nerve health in various challenging anatomical locations (sciatic and median/ulnar nerves) was verified in a chronic feline model in vivo.
Diagnostic Accuracy of Real-Time PCR Assays Targeting 16S rRNA and lipl32 Genes for Human Leptospirosis in Thailand: A Case-Control Study

Background Rapid PCR-based tests for the diagnosis of leptospirosis can provide information that contributes towards early patient management, but these have not been adopted in Thailand. Here, we compare the diagnostic sensitivity and specificity of two real-time PCR assays targeting rrs or lipL32 for the diagnosis of leptospirosis in northeast Thailand. Methods/Principal Findings A case-control study of 266 patients (133 cases of leptospirosis and 133 controls) was constructed to evaluate the diagnostic sensitivity and specificity (DSe & DSp) of both PCR assays. The median duration of illness prior to admission of cases was 4 days (IQR 2–5 days; range 1–12 days). DSe and DSp were determined using positive culture and/or microscopic agglutination test (MAT) as the gold standard. The DSe was higher for the rrs assay than the lipL32 assay (56%, (95% CI 47–64%) versus 43%, (95% CI 34–52%), p<0.001). No cases were positive for the lipL32 assay alone. There was borderline evidence to suggest that the DSp of the rrs assay was lower than the lipL32 assay (90% (95% CI 83–94%) versus 93%, (95%CI 88–97%), p = 0.06). Nine controls gave positive reactions for both assays and 5 controls gave a positive reaction for the rrs assay alone. The DSe of the rrs and lipL32 assays were high in the subgroup of 39 patients who were culture positive for Leptospira spp. (95% and 87%, respectively, p = 0.25). Conclusions/Significance Early detection of Leptospira using PCR is possible for more than half of patients presenting with leptospirosis and could contribute to individual patient care.
Magnetoelectric Response in (1−x)PbZr0.65Ti0.35O3–xBaFe12O19 Multiferroic Ceramic Composites

The magnetoelectric (ME) properties of PbZr0.65Ti0. 35O3-BaFe12O19 (PZT-BaM) multiferroic ceramic composites have been investigated in this work. These materials, containing both the ferroelectric PZT and ferrimagnetic BaM phases, were prepared from the conventional solid-state reaction method, and their main (micro) structural characteristics are provided. The ME measurements were performed over wide frequency and temperature ranges, and the influence of the BaM content was appraised. An enhanced ME coefficient (alpha) was obtained for the applied magnetic field of 0.8 kOe, at 97 kHz. In addition, the results reveal a high thermal stability of alpha in the whole analyzed temperature range, showing that the studied PZT-based ceramic composites have great potential for practical applications.
Application of functional magnetic resonance imaging in psychiatric clinical evaluation: Controversies and avenues

RATIONALE, AIMS, AND OBJECTIVES In this study, we have attempted to replicate the findings of altered emotional processing in depressed patients compared with healthy controls by means of functional magnetic resonance imaging during passive viewing of positive, negative, and neutral pictures from the International Affective Pictures System. METHODS Nineteen medicated depressed patients and 19 sex and age-matched healthy controls underwent functional magnetic resonance imaging during presentation of affective pictures in a block design. The differences between the blood oxygen level dependent signal elicited in the tree conditions were compared. Within-group and between-group analyses were performed with stringent criteria for statistical inference (P < .05 with family-wise error correction). RESULTS In medicated depressed patients, positive pictures compared with neutral pictures activated predominantly the posterior cingulate cortex and precuneus, as well as occipital and middle temporal areas mainly on the left side, while in healthy controls, only the occipito-temporal areas demonstrated significant activation. The negative pictures elicited stronger activation of occipital and temporal regions in both groups and of inferior frontal gyrus only in control subjects. The difference between the groups did not reach statistical significance. Positive correlation was demonstrated between activation levels of clusters located in left precuneus/posterior cingulate cortex and left inferior/middle occipital gyrus and Montgomery-Asberg Depression Rating Scale scores in patients while viewing positive compared with neutral pictures. CONCLUSIONS Although the within-group analysis demonstrated significant activations in both groups with apparent discrepancies, the between-group analysis did not reach statistical significance under the stringent criteria for statistical inference. These results are further contextualized in the critical debate on the methodological issues of clinical evaluation in psychiatry, more specifically the validity and consistency of the applied methods and the limitations existing in the attempts to provide sound cross-disciplinary validation of the diagnostic tools by means of neuroscience.
[Factors affecting the maintenance of occupational activity over a 2-3-year period after total hip replacement].

BACKGROUND The purpose of this paper was to assess the occupational activity in patients after hip replacement over a 2-3-year post operational period and to analyze the effect of selected factors (age, gender, body mass index (BMI), functional state and self-assessed health status) on this activity. MATERIAL AND METHODS In the research 107 people (56 women and 51 men) participated. The average age of the subject's was 55.1 years. A standardized author's survey questionnaire, including questions about personal and clinical data, occupational activity and self-assessment of health status, was applied. The body mass and height were measured and the BMI index was calculated. The 100 points Harris Hip Score (HHS) was used to assess the functional state in the respondents. RESULTS After the operation about 60% of the patients were not occupationally active; 44 (41.1%) respondents received the state health benefit, 18 (16,8%) respondents were eligible for pension benefit, and 2 (1.9%) respondents were unemployed with benefit. No one unemployed before the operation undertook work afterwards. Neither gender nor the character of the job or BMI exerted statistically significant effect on the occupational activity after the operation. Significant differences were noted in undertaking the occupational activity after the operation in patients with different level of functional efficiency assessed with the use of HHS (p = 0.0350) and different level of self-assessed health statuse (p = 0.0057). CONCLUSIONS More than half of the respondents have not returned to work after total hip replacement, while people doing intellectual work most frequently returned to occupation after surgery. Age, functional efficiency, and self-assessed health status of the patient had a significant influence on their return to work. Med Pr 2018;69(2):191-198.
MAP-Based Perceptual Modeling for Noisy Speech Recognition

This study presents a maximum a posteriori (MAP) based perceptual modeling approach to deal with the issue of recognition degradation in noisy environment. In this approach, MAP-based noise detection is first applied to identify the noise segment in an utterance. Subtractive-type enhancement algorithm with masking properties of the human auditory system is then used to reduce the noise effect. Finally, MAP-based incremental noise model adaptation is developed to overcome the model inconsistencies between training and testing environments. For performance evaluation of the proposed approach, a Mandarin keyword recognition system was constructed. The experimental results show that the proposed approach achieves a better recognition rate compared to the audible noise suppression (ANS) and parallel model combination (PMC) methods.
Real-time image detail enhancement implementing on multi-core DSP platform

Image detail enhancement is of wide application in image processing fields. In order to gain a better performance for detail enhancement, the computing cost is normally very large. Thus, it's unacceptable in real-time applications, such as video enhancement. In this paper, we propose a novel parallel framework for reliable real-time image detail enhancement based on recent proposed Gradient Domain Bilateral Filter (GDBF) which is realized on a multicore DSP platform: TMS320C6678. With the implement of parallel enhancement method, not only image base layer and detail layer are rapidly separated, but also the detail layer is further enhanced. Furthermore, the implementation of the parallel framework employs fix point programming instead of float point. With a bit-shift strategy for input image data, the computing precision is well satisfied. Experimental results show that our proposed framework outperform available state-of-the-art one, the processing time for 1080p image is less than 30ms. It is a good candidate for real-time image detail enhancement based on the multi-core DSP.
Is Aquatic Life Correlated with an Increased Hematocrit in Snakes?

Background Physiological adaptations that allow air-breathing vertebrates to remain underwater for long periods mainly involve modifications of the respiratory system, essentially through increased oxygen reserves. Physiological constraints on dive duration tend to be less critical for ectotherms than for endotherms because the former have lower mass-specific metabolic rates. Moreover, comparative studies between marine and terrestrial ectotherms have yet to show overall distinct physiological differences specifically associated with oxygen reserves. Methodology/Principal Findings We used phylogenetically informed statistical models to test if habitat affects hematocrit (an indicator of blood oxygen stores) in snakes, a lineage that varies widely in habitat use. Our results indicate that both phylogenetic position (clade) and especially habitat are significant predictors of hematocrit. Our analysis also confirms the peculiar respiratory physiology of the marine Acrochordus granulatus. Conclusion/Significance Contrary to previous findings, marine snakes have significantly–albeit slightly–elevated hematocrit, which should facilitate increased aerobic dive times. Longer dives could have consequences for foraging, mate searching, and predation risks. Alternatively, but not exclusively, increased Hct in marine species might also help to fuel other oxygen-demanding physiological adaptations, such as those involved in osmoregulation.
The Use of Phonetic Motor Invariants Can Improve Automatic Phoneme Discrimination

We investigate the use of phonetic motor invariants (MIs), that is, recurring kinematic patterns of the human phonetic articulators, to improve automatic phoneme discrimination. Using a multi-subject database of synchronized speech and lips/tongue trajectories, we first identify MIs commonly associated with bilabial and dental consonants, and use them to simultaneously segment speech and motor signals. We then build a simple neural network-based regression schema (called Audio-Motor Map, AMM) mapping audio features of these segments to the corresponding MIs. Extensive experimental results show that a small set of features extracted from the MIs, as originally gathered from articulatory sensors, are dramatically more effective than a large, state-of-the-art set of audio features, in automatically discriminating bilabials from dentals; the same features, extracted from AMM-reconstructed MIs, are as effective as or better than the audio features, when testing across speakers and coarticulating phonemes; and dramatically better as noise is added to the speech signal. These results seem to support some of the claims of the motor theory of speech perception and add experimental evidence of the actual usefulness of MIs in the more general framework of automated speech recognition.
A back-illuminated global-shutter CMOS image sensor with pixel-parallel 14b subthreshold ADC

Rolling-shutter CMOS image sensors (CISs) are widely used [1,2]. However, the distortion of moving subjects remains an unresolved problem, regardless of the speed at which these sensors are operated. It has been reported that by adopting in-pixel analog memory (MEM) in pixels, a global shutter (GS) can be achieved by saving all pixels simultaneously as stored charges [3,4]. However, as signals from a storage unit are read in a column-wise sequence, a light-shielding structure is required for the MEM to suppress the influence of parasitic light during the reading period. Pixel-parallel ADCs have been reported as methods of implementing GS on a circuit [5,6]. However, these techniques have not been successful in operations on megapixels because they do not address issues such as the timing constraint for reading and writing a digital signal to and from an ADC in a pixel owing to increase in the number of pixels and the increase in the total power consumption of massively parallel comparators (CMs).
Fatigue and Insufficient Leisure Opportunities in Older Employees

Objective: The aim of this study was to investigate the impact of age on fatigue prevalence and the potential recovery effect of leisure opportunities. Methods: The study was based on the Austrian Health Interview Survey 2006/2007. We investigated data of a subsample of working adults, which consisted of 5018 subjects (51.8% males) aged 35 to 59 years. A logistic regression analysis stratified by gender explored whether age and leisure opportunities predicted prolonged fatigue. Results: Age was not associated with fatigue in females, but older male employees (55 to 59 years) were at a greater risk for fatigue than the reference group (35 to 39 years). Insufficient leisure opportunities increased the odds for fatigue in both genders and all age groups. However, this effect was especially pronounced in male employees aged 55 to 59 years. Conclusions: These results suggest that older male employees may be in need of more leisure opportunities to recover from work.
GISentinel: a software platform for automatic ulcer detection on capsule endoscopy videos

In this paper, we present a novel and clinically valuable software platform for automatic ulcer detection on gastrointestinal (GI) tract from Capsule Endoscopy (CE) videos. Typical CE videos take about 8 hours. They have to be reviewed manually by physicians to detect and locate diseases such as ulcers and bleedings. The process is time consuming. Moreover, because of the long-time manual review, it is easy to lead to miss-finding. Working with our collaborators, we were focusing on developing a software platform called GISentinel, which can fully automated GI tract ulcer detection and classification. This software includes 3 parts: the frequency based Log-Gabor filter regions of interest (ROI) extraction, the unique feature selection and validation method (e.g. illumination invariant feature, color independent features, and symmetrical texture features), and the cascade SVM classification for handling "ulcer vs. non-ulcer" cases. After the experiments, this SW gave descent results. In frame-wise, the ulcer detection rate is 69.65% (319/458). In instance-wise, the ulcer detection rate is 82.35%(28/34). The false alarm rate is 16.43% (34/207). This work is a part of our innovative 2D/3D based GI tract disease detection software platform. The final goal of this SW is to find and classification of major GI tract diseases intelligently, such as bleeding, ulcer, and polyp from the CE videos. This paper will mainly describe the automatic ulcer detection functional module.
Acute and long‐term effects of blood flow restricted training on heat shock proteins and endogenous antioxidant systems

Blood flow restricted exercise (BFRE) with low loads has been demonstrated to induce considerable stress to exercising muscles. Muscle cells have developed a series of defensive systems against exercise‐induced stress. However, little is known about acute and long‐term effects of BFRE training on these systems. Nine previously untrained females trained low‐load BFRE and heavy load strength training (HLS) on separate legs and on separate days to investigate acute and long‐term effects on heat shock proteins (HSP) and endogenous antioxidant systems in skeletal muscles. BFRE and HLS increased muscle strength similarly by 12 ± 7% and 12 ± 6%, respectively, after 12 weeks of training. Acutely after the first BFRE and HLS exercise session, αB‐crystallin and HSP27 content increased in cytoskeletal structures, accompanied by increased expression of several HSP genes. After 12 weeks of training, this acute HSP response was absent. Basal levels of αB‐crystallin, HSP27, HSP70, mnSOD, or GPx1 remained unchanged after 12 weeks of training, but HSP27 levels increased in the cytoskeleton. Marked translocation of HSP to cytoskeletal structures at the commencement of training indicates that these structures are highly stressed from BFRE and HLS. However, as the muscle gets used to this type of exercise, this response is abolished.
Serological Markers Suggest Heterogeneity of Effectiveness of Malaria Control Interventions on Bioko Island, Equatorial Guinea

Background In order to control and eliminate malaria, areas of on-going transmission need to be identified and targeted for malaria control interventions. Immediately following intense interventions, malaria transmission can become more heterogeneous if interventions are more successful in some areas than others. Bioko Island, Equatorial Guinea, has been subject to comprehensive malaria control interventions since 2004. This has resulted in substantial reductions in the parasite burden, although this drop has not been uniform across the island. Methods/Principal Findings In 2008, filter paper blood samples were collected from 7387 people in a cross-sectional study incorporating 18 sentinel sites across Bioko, Equatorial Guinea. Antibodies were measured to P. falciparum Apical Membrane Antigen-1 (AMA-1) by Enzyme Linked Immunosorbent Assay (ELISA). Age-specific seropositivity rates were used to estimate seroconversion rates (SCR). Analysis indicated there had been at least a 60% decline in SCR in four out of five regions on the island. Changes in SCR showed a high degree of congruence with changes in parasite rate (PR) and with regional reductions in all cause child mortality. The mean age adjusted concentration of anti-AMA-1 antibodies was mapped to identify areas where individual antibody responses were higher than expected. This approach confirmed the North West of the island as a major focus of continuing infection and an area where control interventions need to be concentrated or re-evaluated. Conclusion/Interpretation Both SCR and PR revealed heterogeneity in malaria transmission and demonstrated the variable effectiveness of malaria control measures. This work confirms the utility of serological analysis as an adjunct measure for monitoring transmission. Age-specific seroprevalence based evidence of changes in transmission over time will be of particular value when no baseline data are available. Importantly, SCR data provide additional evidence to link malaria control activities to contemporaneous reductions in all-cause child mortality.