Miracle-dz/UniFAR-FTUs huggingface dataset:
Maternal and Paternal Smoking During Pregnancy and Risk of ADHD Symptoms in Offspring: Testing for Intrauterine Effects

Maternal smoking during pregnancy is associated with attention deficit hyperactivity disorder (ADHD) in offspring. It is assumed by many that this association is causal. Others suggest that observed associations are due to unmeasured genetic factors or other confounding factors. The authors compared risks of maternal smoking during pregnancy with those of paternal smoking during pregnancy. With a causal intrauterine effect, no independent association should be observed between paternal smoking and offspring ADHD. If the association is due to confounding factors, risks of offspring ADHD should be of similar magnitudes regardless of which parent smokes. This hypothesis was tested in 8,324 children from a well-characterized United Kingdom prospective cohort study, the Avon Longitudinal Study of Parents and Children (data from 1991–2000). Associations between offspring ADHD and maternal and paternal smoking during pregnancy were compared using regression analyses. Offspring ADHD symptoms were associated with exposure to both maternal and paternal smoking during pregnancy (mothers: β = 0.25, 95% confidence interval: 0.18, 0.32; fathers: β = 0.21, 95% confidence interval: 0.15, 0.27). When paternal smoking was examined in the absence of maternal smoking, associations remained and did not appear to be due to passive smoking exposure in utero. These findings suggest that associations between maternal smoking during pregnancy and child ADHD may be due to genetic or household-level confounding rather than to causal intrauterine effects.
People Watcher: An App to Record and Analyzing Spatial Behavior of Ubiquitous Interaction Technologies

In this paper we argue that interfaces embedded in the world, one of the core objectives of ubiquitous computing, require interaction designers and researchers to have a stronger understanding of the environment as an aspect of the interaction process. We suggest that the interaction community needs new tools to accurately record and, as importantly, analyze interaction in space. We present one solution: People Watcher, a freely downloadable, iPad Application, specifically designed to address the `usability in space' issues. The paper reports a case study of the software's use. We go on to encourage researchers to adopt this tool as part of the wider process of understanding the effect of the spatial context in interaction design.
A Fragment-Based Approach for the Computational Prediction of the Nonspecific Binding of Drugs to Hepatic Microsomes

Correction for the nonspecific binding (NSB) of drugs to liver microsomes is essential for the accurate measurement of the kinetic parameters Km and Ki, and hence in vitro–in vivo extrapolation to predict hepatic clearance and drug–drug interaction potential. Although a number of computational approaches for the estimation of drug microsomal NSB have been published, they generally rely on compound lipophilicity and charge state at the expense of other physicochemical and chemical properties. In this work, we report the development of a fragment-based hologram quantitative structure activity relationship (HQSAR) approach for the prediction of NSB using a database of 132 compounds. The model has excellent predictivity, with a noncross-validated r2 of 0.966 and cross-validated r2 of 0.680, with a predictive r2 of 0.748 for an external test set comprising 34 drugs. The HQSAR method reliably predicted the fraction unbound in incubations of 95% of the training and test set drugs, excluding compounds with a steroid or morphinan 4,5-epoxide nucleus. Using the same data set of compounds, performance of the HQSAR method was superior to a model based on logP/D as the sole descriptor (predictive r2 for the test set compounds, 0.534). Thus, the HQSAR method provides an alternative approach to laboratory-based procedures for the prediction of the NSB of drugs to liver microsomes, irrespective of the drug charge state (acid, base, or neutral).
Is Incidental Finding the Best Term? A Study of Patients’ Preferences

Purpose— There is debate within the genetics community about the optimal term to describe genetic variants unrelated to the test indication, but potentially important for health. Given the lack of consensus and the importance of adopting terminology that promotes effective clinical communication, we sought the opinion of clinical genetics patients. Methods— Surveys and focus groups with two patient populations were conducted. Eighty-eight survey participants were asked to rank four terms according to how well each describes results unrelated to the test indication: incidental findings, secondary findings, additional findings, and ancillary findings. Participants in six focus groups were guided through a free-thought exercise to describe desired attributes of such a term, and then asked to formulate a best term to represent this concept. Results— The term additional findings had the most first choice rankings by survey participants, followed by secondary findings, incidental findings, and ancillary findings. Most focus group participants preferred the term additional findings; they also described reasons why other terms were not optimal. Conclusion— Additional findings was preferred as both more neutral and accessible than other terms currently in use. Patient perceptions and comprehension will be framed by the terminology. Thus, patient opinions should be considered by medical genetics professionals.
Template Matching, Alignment and Averaging of Sub-Tomograms in Electron Cryo-Tomography Reconstructions using Jsubtomo

Electron cryo-tomography has emerged as a widely used method for imaging different biological specimens and elucidating their three-dimensional structures. Suitable specimens range from macromolecular complexes, filamentous structures, coated vesicles and pleomorphic membrane viruses to procaryotic cells and thin areas eukaryotic cells. After sample preparation for electron cryo-microscopy, a tomographic tilt series is collected from the sample area of interest, from which a three-dimensional density map (a tomogram) can be calculated. Two complications limit the usefulness of these data: first, low signal-to-noise ratio, inherent to all electron cryo-microscopy data, and second, the missing wedge problem, inherent to all tomographic reconstructions with limited tilting range. However, if the tomogram contains several identical structures (particles), such as macromolecular complexes, these complications can be overcome by averaging several sub-tomograms, each containing a single particle.
Hydrogen Induced Crack and Phase Transformation in Hydrogen Pressured Tensile Test of 316L Stainless Steel

The aim of this investigation is to prove the mechanism of hydrogen induced crack (HIC) of 316L stainless steels in hydrogen pressured tensile test. Microstructures like twin, planar slip, and abnormal phase transformation around the HIC were analyzed by transmission electron microscopy. Deformation twin accompanied by planar slip could be related to the main cause of HIC in the hydrogen pressured tensile condition, because intragranular HICs were mainly observed along the boundaries of twins and planar slip lines. An abnormal forbidden diffraction was also accompanied by HIC in the hydrogen attacked area. Examination of the HIC mechanism in austenitic stainless steel can be applied to the fitness of use for alloys with the possibility of various susceptible cracks in a hydrogen and stress atmosphere. †(Received February 16, 2014)
Small Scale Plasticity With Confinement and Interfacial Effects

The mechanical properties of crystalline metals are strongly affected when the sample size is limited to the micron or sub-micron scale. At these scales, the mechanical properties are enhanced far beyond classical predictions. Besides, the surface to volume ratio significantly increases. Therefore surfaces and interfaces play a big role in the mechanical properties of these micro-samples. The effect of different interfaces on the mechanical properties of micro-samples is not yet well understood. The aim of this project is to characterize, understand, and predict the effect of confinement on deformation mechanisms at micro-scale. In this study, micro-pillars were fabricated by Focused Ion Beam (FIB). Micro-pillars were homogeneously coated with thin films by magnetron sputtering and cathodic arc deposition. The mechanical properties of carbon-coated-, chromium coated-, naked-, annealed- and non-annealed micro-pillars were measured. Afterwards, the results of micro-compression tests and Automated Crystal Orientation Mapping on Transmission electron microscopy (ACOM TEM) were compared and led to some surprising new findings.Dislocations are blocked by amorphous- and even crystalline coating in the deformed samples. Parallel slip systems were detected in the chromium layer and the copper micro-pillar. Even though the chromium layer has parallel slip systems, dislocation pile-up at the interface was found after deformation. The most significant finding in this study concerns the back stress of the dislocation pile-up, which affects the dislocation sources and causes an increase of the flow stress to generate new dislocations from these sources. Thermal annealing increases the strength and flow stress of FIB fabricated micro samples. The annealing treatment restores the lattice that was damaged by the FIB fabrication process. A higher stress is required to initiate the dislocation nucleation in a pristine lattice. Techniques of fabrication and investigation were developed to study the role of confinement and interfaces on the mechanical properties of materials at micro scale. Mechanisms of deformation were unraveled and a better understanding of the key parameters was reached.
Relationship between Exposure to Vector Bites and Antibody Responses to Mosquito Salivary Gland Extracts

Mosquito-borne diseases are major health problems worldwide. Serological responses to mosquito saliva proteins may be useful in estimating individual exposure to bites from mosquitoes transmitting these diseases. However, the relationships between the levels of these IgG responses and mosquito density as well as IgG response specificity at the genus and/or species level need to be clarified prior to develop new immunological markers to assess human/vector contact. To this end, a kinetic study of antibody levels against several mosquito salivary gland extracts from southeastern French individuals living in three areas with distinct ecological environments and, by implication, distinct Aedes caspius mosquito densities were compared using ELISA. A positive association was observed between the average levels of IgG responses against Ae. caspius salivary gland extracts and spatial Ae. caspius densities. Additionally, the average level of IgG responses increased significantly during the peak exposure to Ae. caspius at each site and returned to baseline four months later, suggesting short-lived IgG responses. The species-specificity of IgG antibody responses was determined by testing antibody responses to salivary gland extracts from Cx. pipiens, a mosquito that is present at these three sites at different density levels, and from two other Aedes species not present in the study area (Ae. aegypti and Ae. albopictus). The IgG responses observed against these mosquito salivary gland extracts contrasted with those observed against Ae. caspius salivary gland extracts, supporting the existence of species-specific serological responses. By considering different populations and densities of mosquitoes linked to environmental factors, this study shows, for the first time, that specific IgG antibody responses against Ae. caspius salivary gland extracts may be related to the seasonal and geographical variations in Ae. caspius density. Characterisation of such immunological-markers may allow the evaluation of the effectiveness of vector-control strategies or estimation of the risk of vector-borne disease transmission.
Notes on stochastic processes Paul Keeler

A stochastic process is a type of mathematical object studied in mathematics, particularly in probability theory, which can be used to represent some type of random evolution or change of a system. There are many types of stochastic processes with applications in various fields outside of mathematics, including the physical sciences, social sciences, finance and economics as well as engineering and technology. This survey aims to give an accessible but detailed account of various stochastic processes by covering their history, various mathematical definitions, and key properties as well detailing various terminology and applications of the process. An emphasis is placed on non-mathematical descriptions of key concepts, with recommendations for further reading.
Psychometric properties of the Canadian Occupational Performance Measure in home-dwelling older adults

Background The Canadian Occupational Performance Measure (COPM) is an occupational therapy instrument designed to help participants identify, prioritize, and evaluate performance of important occupations. Objective To investigate the validity, responsiveness, interpretability, and feasibility of the COPM when used by various health professions in home-dwelling older adults receiving reablement. Reablement is a new form of multidisciplinary home-based rehabilitation for older adults experiencing functional decline. Participants and methods The sample of 225 participants, mean age 80.8 years, who were in need of rehabilitation for various health conditions were included in the study. Data collection was conducted at baseline and at 10 weeks follow-up. The COSMIN guidelines and recommendations for evaluating methodological quality were followed. Results Content validity, construct validity, and feasibility were found to be adequate. Responsiveness, however, was moderate. Functional mobility was the most frequently prioritized occupational category of all. Regarding interpretability, the minimal important change was 3.0 points and 3.2 points for performance and satisfaction, respectively. The older adults reported that COPM was a useful and manageable instrument. The majority of the occupational therapists, physiotherapists, and nurses reported that they had the required expertise to conduct the COPM assessments. Conclusion The results support the multidisciplinary use of the COPM in clinical practice and research in a home-dwelling, heterogeneous population of older adults. Based on the findings, 3 points are recommended as a cutoff point to distinguish between older adults who have a minimal important change in COPM performance and COPM satisfaction and those who have not.
Application of polymeric nanofibers in medical designs, part II: Neural and cardiovascular tissues

ABSTRACT Nanotechnology has wide applications in many fields, especially in the biological sciences and medicine. Nanomaterials are applied as potential materials for treatment and diagnosis. Nanofibers mimic the porous topography of natural extracellular matrix, are advantageous for tissue regeneration and also for sustained release of encapsulated drug or growth factor. The author summarizes the currently available applications of nanofibers in two soft tissues of nerve and cardiovascular tissues. Shown in the graphic are Schwann cells seeded on different nanofibers under scanning electron microscope. GRAPHICAL ABSTRACT
Molecular genomic landscapes of hepatobiliary cancer

Hepatocellular carcinoma (HCC) and biliary tract cancer are more frequent in East Asia including Japan than in Europe or North America. A compilation of 1340 multi‐ethnic HCC genomes, the largest cohort ever reported, identified a comprehensive landscape of HCC driver genes, comprised of three core drivers (TP53, TERT, and WNT signaling) and combinations of infrequent alterations in various cancer pathways. In contrast, five core driver genes (TP53, ARID1A, KRAS, SMAD4, and BAP1) with characteristic molecular alterations including fusion transcripts involving fibroblast growth factor receptor 2 and the protein kinase A pathway, and IDH1/2 mutation constituted the biliary tract cancer genomes. Consistent with their heterogeneous epidemiological backgrounds, mutational signatures and combinations of non‐core driver genes within these cancer genomes were found to be complex. Integrative analyses of multi‐omics data identified molecular classifications of these tumors that are associated with clinical outcome and enrichments of potential therapeutic targets, including immune checkpoint molecules. Translating comprehensive molecular‐genomic analysis together with further basic research and international collaborations are highly anticipated for developing precise and better treatments, diagnosis, and prevention of these tumor types.
Testing and development of an instrument for self-report of participation and related environmental factors – Your Ideas about Participation and Environment (YIPE) among adults with brain injury

Abstract Purpose: To examine the usability of the self-report instrument, Your Ideas about Participation and Environment (YIPE), among adults with a brain injury by exploring the value and acceptability of the instrument. Methods: A qualitative descriptive research design was used for the purpose of testing and developing the YIPE for use among adults with a brain injury. The study involved administering the YIPE followed by in-depth interviewing about the experience of taking the instrument with seven adults with a brain injury, recruited through a community-based support service organization. A descriptive thematic approach was used to analyse the content of the interview data, categorize common ideas and identify areas for improvement within the instrument. Results: Participants were generally positive about the importance of the participation and environment topics and willing to engage in self report. The YIPE (2012), resulting from changes made to the language and structure, was found to be more useable, valued and accepted by these participants than the previous version, YIPE (2011). Conclusions: The YIPE was found to be a useful tool among study participants. The YIPE topics were found to have importance and relevance when considering participants’ satisfaction with areas of life and aspects of environment requiring change. More development of the tool is required in terms of the wording, format and method of administration to improve the overall usability of the instrument. Implications for Rehabilitation The preliminary results from this small sample study illustrated that people with brain injury were able to use an International Classification of Functioning, Disability and Health-based tool, and confirmed the importance of considering both participation and the environment together. People with cognitive impairments associated with brain injury reported on areas of everyday life where they were satisfied or dissatisfied. They related their satisfaction to environmental factors that were facilitators or barriers to valued everyday activities. The opportunity to choose important life areas promotes individuals’ motivation to engage and enables service providers to tailor rehabilitation. In the course of the two stages of research, it was necessary to make minor modifications to the language, structure and scoring system of the tool, to simplify the task and shorten the time to interview participants.
Baboon Feeding Ecology Informs the Dietary Niche of Paranthropus boisei

Hominins are generally considered eclectic omnivores like baboons, but recent isotope studies call into question the generalist status of some hominins. Paranthropus boisei and Australopithecus bahrelghazali derived 75%–80% of their tissues’ δ13C from C4 sources, i.e. mainly low-quality foods like grasses and sedges. Here I consider the energetics of P. boisei and the nutritional value of C4 foods, taking into account scaling issues between the volume of food consumed and body mass, and P. boisei’s food preference as inferred from dento-cranial morphology. Underlying the models are empirical data for Papio cynocephalus dietary ecology. Paranthropus boisei only needed to spend some 37%–42% of its daily feeding time (conservative estimate) on C4 sources to meet 80% of its daily requirements of calories, and all its requirements for protein. The energetic requirements of 2–4 times the basal metabolic rate (BMR) common to mammals could therefore have been met within a 6-hour feeding/foraging day. The findings highlight the high nutritional yield of many C4 foods eaten by baboons (and presumably hominins), explain the evolutionary success of P. boisei, and indicate that P. boisei was probably a generalist like other hominins. The diet proposed is consistent with the species’ derived morphology and unique microwear textures. Finally, the results highlight the importance of baboon/hominin hand in food acquisition and preparation.
Situated Cultural Differences: A Tool for Analyzing Cross-Cultural Co-Creation

Designers in the global era are increasingly challenged to design for diverse cultural context. Both ethnographic and participatory design research methods are integral for conducting cultural inquiries. Cocreation offers an interactive setting for researcher to gain meaningful insights into the tacit and latent aspects of culture. The analysis framework for this study is based on the theoretical construct of situated cultural differences. In the process of co-creation, situated cultural differences become a diagnostic tool used by researchers to categories participants’ everyday experiences into meaningful cultural categories. This paper work focused on identifying the different situated differences used by participants during the co-creation sessions and creating a typology of differences. The analysis was focused on how the research team interpreted the situated differences to establish the underlying cultural values. Four categories of situated cultural differences emerged from the data: material-observable, material-ideological, behavioral-observable and behavioral ideological. The analysis shows that participants preferred the material and behavioral-ideological type of situated differences. This study provides a methodological approach for analyzing cultural differences and integrating diverse cultural aspects into a systematic framework. The theoretical framework of cultural situated differences and the typology of differences provides a framework for designer, design researchers and corporations to identify, categorize and design for cultural differences.