Miracle-dz/UniFAR-FTUs huggingface dataset:
Exposure to antineoplastic drugs in two UK hospital pharmacy units.

STUDY OBJECTIVES To carry out an environmental and biological monitoring study in two UK hospital pharmacy units involved in the preparation of antineoplastic drugs. PARTICIPANTS AND METHODS The two units studied used isolators for drug preparation. One used isolators operating at positive pressure relative to external atmospheric pressure, whereas the other used negative pressure isolators. Monitoring utilized the measurements of methotrexate, ifosfamide, cyclophosphamide and platinum reflecting the platino-coordinated drugs, such as cisplatin and carboplatin. Personal and static atmospheric and floor wipe samples were collected together with preshift and post-shift urine samples over a 4-day consecutive monitoring period. During the study period both units operated to their normal procedures. RESULTS Measurable amounts of cytotoxic drugs were detected on the floors of both units and on the disposable gloves worn by staff preparing the drugs. There was also evidence in both units of some very low-level drug absorption from urine measurements, using the most sensitive analytical technique of platinum analysis. The absorption of platinum containing drugs in the unit using negative-pressure isolators was significantly higher, even though less platinum containing drug was prepared per day. Urine measurements in both units were below the detection limit for the other measured drugs. Although the unit using positive-pressure isolators handled daily approximately five times the drug quantities handled with the negative pressure unit, the general levels of external contamination and urine measurements did not reflect this difference. Comparison of the relative levels of glove and floor contamination between the two units was not clear-cut and appeared to depend on the specific cytotoxic drug being monitored. CONCLUSIONS The levels of external contamination on the floor and gloves, and absorbed dose from urine measurements found in this study showed considerable improvement over many earlier, non-UK studies using comparable exposure measurements. These earlier studies were in facilities using laminar flow/microbiological safety cabinets and where staff were likely to be involved in both drug preparation and administration. Our data did not suggest that the differential pressure of the isolator to the pharmacy atmosphere was an overarching factor in the risk of operator exposure under normal operation. There remains a need to investigate the sources of the low-level drug contamination found in the pharmacies even when using isolators to prepare cytotoxic drugs. This study, and related studies of hospital oncology ward staff, appear to be the only recent UK studies of occupational cytotoxic drug exposure using environmental and biological monitoring techniques.
Low-mode averaging for baryon correlation functions

The low-mode averaging technique is a powerful tool for reducing large fluctuations in correlation functions due to low-mode eigenvalues of the Dirac operator. In this work we propose a generalization to baryons and test our method on two-point correlation functions of left-handed nucleons, computed with quenched Neuberger fermions on a lattice with extension L=1.5 fm. We show that the statistical fluctuations can be reduced and the baryon signal significantly improved.
Projection Processes in the Perception of Political Leaders

The perception of similarity between voters and politicians deeply affects political judgments. In the present work we investigated how voters may selectively attempt to increase their perceived similarity with liked political leaders by means of projection processes. In two studies, participants had to guess the month of birth of several politicians. The attribution of the personal month of birth was assessed. Data provided evidence of both positive and negative projection processes: As compared to what was expected on the basis of random attributions, one's own month of birth was more likely attributed to politicians of the ingroup but denied to politicians belonging to the disliked coalition. Overall, findings demonstrate that participants modulate their perceived distance with political leaders through selective projection processes, using the self as a judgmental anchor.
Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1*

Sphingolipid (SL) biosynthesis is negatively regulated by the highly conserved endoplasmic reticulum-localized Orm family proteins. Defective SL synthesis in Saccharomyces cerevisiae leads to increased phosphorylation and inhibition of Orm proteins by the kinase Ypk1. Here we present evidence that the yeast morphogenesis checkpoint kinase, Swe1, regulates SL biosynthesis independent of the Ypk1 pathway. Deletion of the Swe1 kinase renders mutant cells sensitive to serine palmitoyltransferase inhibition due to impaired sphingoid long-chain base synthesis. Based on these data and previous results, we suggest that Swe1 kinase perceives alterations in SL homeostasis, activates SL synthesis, and may thus represent the missing regulatory link that controls the SL rheostat during the cell cycle.
Title Testing of Snps and Snp Interactions in Case-parent Trio Studies

Description Testing SNPs and SNP interactions with a genotypic TDT. This package furthermore contains functions for computing pairwise values of LD measures and for identifying LD blocks, as well as functions for setting up matched case pseudo-control genotype data for case-parent trios in order to run trio logic regression, for imputing missing genotypes in trios, for simulating case-parent trios with disease risk dependent on SNP interaction, and for power and sample size calculation in trio data.
Specifying and estimating multilevel models for geographical research

It is argued that multi-level models based on shrinkage estimators represent a considerable improvement over single-level models estimated by ordinary-least squares. In substantive terms, the ML models allow relationships to vary in time and space according to context. Shrinkage estimators make very efficient use of the information contained in the hierprchical data sets that are estimated by ML models. A number of ML models for house-price variation are specified in terms of fixed and random, allowed-to-vary, effects. Empirical illustrations of some of these ML models are given for house-price variation in Southampton.
Automatic Extraction of Verb Phrases from Annotated Corpora: a Linguistic Evaluation for Estonian under Consideration for Other Conferences (specify)? No

Statistically-based phrase extractors are fundamental tools for the improvement of Natural Language Processing applications designed for the new languages of the emerging countries. In this context, we will present a new architecture called SENTA (Software for the Extraction of N-ary Textual Associations) that identifies verbal phrases from lemmatized corpora. In particular, SENTA proposes a solution to the definition of ad hoc association measure thresholds and introduces a new association measure called the Mutual Expectation. In order to evaluate SENTA, an exhaustive linguistic analysis of the results has been carried out that takes advantage of a pre-existing manually created phrasal lexicon.
A Novel Colorimetric Immunoassay Utilizing the Peroxidase Mimicking Activity of Magnetic Nanoparticles

A simple colorimetric immunoassay system, based on the peroxidase mimicking activity of Fe3O4 magnetic nanoparticles (MNPs), has been developed to detect clinically important antigenic molecules. MNPs with ca. 10 nm in diameter were synthesized and conjugated with specific antibodies against target molecules, such as rotaviruses and breast cancer cells. Conjugation of the MNPs with antibodies (MNP-Abs) enabled specific recognition of the corresponding target antigenic molecules through the generation of color signals arising from the colorimetric reaction between the selected peroxidase substrate, 3,3′,5,5′-tetramethylbenzidine (TMB) and H2O2. Based on the MNP-promoted colorimetric reaction, the target molecules were detected and quantified by measuring absorbance intensities corresponding to the oxidized form of TMB. Owing to the higher stabilities and economic feasibilities of MNPs as compared to horseradish peroxidase (HRP), the new colorimetric system employing MNP-Abs has the potential of serving as a potent immunoassay that should substitute for conventional HRP-based immunoassays. The strategy employed to develop the new methodology has the potential of being extended to the construction of simple diagnostic systems for a variety of biomolecules related to human cancers and infectious diseases, particularly in the realm of point-of-care applications.
Transitive closure on the imagine stream processor

The increasing gap between processor and memory speeds is a well-known problem in modern computer architecture. The Imagine system is designed to address the processor-memory gap through streaming technology. Stream processors are best-suited for computationally intensive applications characterized by high data parallelism and producer-consumer locality with minimal data dependencies. This work examines an efficient streaming implementation of the computationally intensive Transitive Closure (TC) algorithm on the Imagine platform. We develop a tiled TC algorithm specifically for the Imagine environment, which efficiently reuses streams to minimize expensive off-chip data transfers. The implementation requires complex stream programming since the memory hierarchy and cluster organization of the underlying architecture are exposed to the Imagine programmer. Results demonstrate that limited performance of TC is achieved primarily due to the complicated data-dependencies of the blocked algorithm. This work is an ongoing effort to identify classes of scientific problems well-suited for streaming processors.
Analysis of the Complexity Entropy and Chaos Control of the Bullwhip Effect Considering Price of Evolutionary Game between Two Retailers

In this research, a model is established to represent a supply chain, which consists of one manufacturer and two retailers. The price-sensitive demand model is considered and the price game system is built according to the rule of bounded rationality as well as the entropy theory. With the increase of the price adjustment speed, the game system may go into chaos from the stable and periodic state. The bullwhip effect and inventory variance ratio of different stages that the system falls in are compared in real time. We also employ the delayed feedback control method to control the system and succeed in mitigating the bullwhip effect of the system. On the whole, the bullwhip effect and inventory variance ratio in the stable state are smaller than those in period-doubling and chaos. In the stable state, there is an optimal price adjustment speed to obtain both the lowest bullwhip effect and inventory variance ratio.
Carbon fiber reinforced polymer integrated antenna module

Rising demand for vehicular communication and cooperative movement have led to an increase of vehicle mounted antennas. A carbon fiber reinforced polymer cavity is presented, that can be integrated into the vehicle chassis. The concealed cavity is large enough to house the anticipated antennas for present and future vehicular communication. Influence of the cavity onto antennas is demonstrated with calibrated gain measurements on the example of a 5.9GHz monopole antenna for intelligent transportation systems. The cavities impact on antenna performance is found to be much smaller than influences of the car itself.
Protein Synthesis Is Required for Synaptic Immunity to Depotentiation

De novo protein synthesis and transcription are necessary for the expression of long-lasting synaptic potentiation [long-term potentiation (LTP)] in hippocampal area CA1 and for the consolidation of long-term memory. The stability of LTP and its longevity require macromolecular synthesis at later stages, but a specific role for early protein synthesis has not been identified. Using electrophysiological recording methods in mouse hippocampal slices, we show that multiple trains of high-frequency stimulation provide immediate synaptic immunity to depotentiation. This immunity to depotentiation is dependent on the amount of synaptic stimulation used to induce LTP, it is input specific, and it is prevented by inhibitors of protein synthesis. We propose that local translation mediates input-specific synaptic immunity against depotentiation. We also present evidence suggesting that, in addition to translation, products of transcription can provide cell-wide immunity to depotentiation via heterosynaptic transfer of synaptic immunity between distinct pathways in area CA1. Protein synthesis and transcription may importantly regulate long-term storage of information by conferring synaptic immunity to depotentiation at previously potentiated synapses.
Evaluation of a programme for increasing the effectiveness of personal problem-solving.

A programme was developed for training people to apply generic problem-solving techniques to their personal problems. These are basic problem-solving operations which, in principle, should be applicable to any specific problem. Sixty-four male student volunteers were divided into sets of internals and externals, on the basis of pre-test scores on the Rotter Internal-External (I-E) scale. They were assigned at random to a training group and a no-training control group, and subjects in the training group attended a five-week programme. Dependent measures included the standard of bachelor's degrees gained by subjects at graduation, the I-E scale, and the neuroticism scale of the Eysenck Personality Inventory. The two scales were administered one week and eight weeks after the programme. Results demonstrated that the training group achieved a higher standard in their bachelor's degrees, developed an increased belief in internal control and became more emotionally stable. There was no evidence of an interaction between locus of control and the effects of the programme.
AN INTRODUCTION TO FUNCTIONAL GRAMMAR . Michael A. K. Halliday. London: Edward Arnold, 1985. Pp. 384.

section is matter of fact and not particularly illuminating, for example, "the children used some new communication strategies, such as comparisons . and avoidance of distinctive expressions" (p. 335-336). The entire work stands best as a description of the acquisition of syntax rather than as an explanatory discussion of strategies or as a theoretical discussion on the psycholinguistics of second language acquisition. The Appendix of six pages is definitely too brief for a work of this scope and detail. If the spontaneous conversations had been listed for the three children, its value as a source for future studies would have been enhanced. However, Koike's book should still be cited along with the better-known longitudinal studies. Comparing it to others such as Taeschner's, Wong-Fillmore's, Fantim's, and Hakuta's, it is weaker in its delineation of strategies but is their equal in its description of the sheer number of patterns acquired. The first edition of this book is virtually sold out, but copies of the dissertation, which is similar in most respects, are available from University Microfilms International, Ann Arbor.
An efficient algorithm for the n-best-strings problem

We present an efficient algorithm for solving the n-best-strings problem in a weighted automaton. This problem arises commonly in speech recognition applications when a ranked list of unique recognizer hypotheses is desired. We believe this is the first n-best algorithm to remove redundant hypotheses before rather than after the n-best determination. We give a detailed description of the algorithm and demonstrate its correctness. We report experimental results showing its efficiency and practicality even for large n in a 40; 000-word vocabulary North American Business News (NAB) task. In particular, we show that 1000-best generation in this task requires negligible added time over recognizer lattice generation.
Genomewide scans of red cell indices suggest linkage on chromosome 6q23

Background: The red cell indices quantify the size, number and oxygen-carrying ability of erythrocytes. Although the genetic basis of many monogenic forms of anaemia is well understood, comparatively little is known about the genes responsible for variation in the red cell indices among healthy participants. Objective: To identify quantitative trait loci (QTLs) responsible for normal variation in the red cell indices of 391 pairs of dizygotic twins who were measured longitudinally at 12, 14 and 16 years of age. Results: Evidence suggesting linkage of red cell indices to haemoglobin concentration (LOD = 3.03) and haematocrit (LOD = 2.95) on chromosome 6q23, a region previously identified as possibly harbouring a QTL for haematocrit, was found. Evidence for linkage to several other regions of the genome, including chromosome 4q32 for red cell count and 7q for mean cell volume, was also found. In contrast, there was little evidence of linkage to the chromosomal regions containing the genes for erythropoietin (7q21) and its receptor (19p13.2), nor to the regions containing the genes for the haemoglobin α (16p13.3) and β chains (11p15.5). Conclusion: Findings provide additional evidence for a QTL affecting haemoglobin and haematocrit on chromosome 6q23. In contrast, polymorphisms in the genes coding for erythropoietin, its receptor and the haemoglobin α and β chains do not appear to contribute substantially to variation in the red cell indices between healthy persons.
SAR imaging with noise waveform and low sampling rate based on sparse optimization

In this paper, we apply sparse optimization method to synthetic aperture radar (SAR) imaging on the airborne data of a Ku-band SAR using noise waveforms. The SAR system transmits chaotic pulse waveforms at three carrier frequencies (13.7GHz, 13.9GHz and 14.1GHz). Each frequency channel has a same bandwidth of 220MHz and the total bandwidth covered by the three channels is 620MHz. According to the compressed sensing (CS) theory and the randomness property of noise signal, we can uniformly down sample the echo data with a rate below the Nyquist sampling rate. Effects of low-rate sampling on noise radar imaging are discussed with simulated 1-D data presented. The reconstruction of SAR image from low-rate samples is based on our recently proposed maximum a posterior (MAP) estimation method, which is developed from the sparse optimization techniques in CS. Experimental results are presented to show the effectiveness of our algorithm.
Navy Basic Test Battery Validity For Success in Naval Occupations

Summary and Conclusions This study set out to investigate the predictive validity of the Navy Basic Test Battery in determining success of naval enlisted personnel on petty officer advancement examinations. The major hypothesis of the study was that the Battery possesses sufficient validity to warrant its use not only as a predictor of success in Navy service schools but also as a predictor of success in on-the-job training and on-the-job performance. To test this hypothesis two independent samples were taken, one year apart, from among populations of candidates for advancement in rating to petty officer, third class, in 23 naval occupations. The first sample was used to derive multiple regression equations from which criterion scores could be predicted on the basis of the Navy Basic Test Battery scores. The second sample was used to cross-validate the regression weights of these equations through an analysis of the zero-order relationship existing between predicted and actual obtained scores. For the 23 naval occupations studied, the multiple R's all proved to be both positive and significantly different from zero. Upon cross-validation, all but one also proved to be both positive and significantly different from zero. The validity coefficients (multiple R's) of this study compared quite favorably with validity coefficients reported for the prediction of school success on the basis of the Test Battery Scores for naval apprentices in these same naval occupations. The major conclusions of this study are: 1. The Navy Basic Test Battery has reasonably high predictive validity in determining success of naval apprentices in the 23 occupations studied. 2. The use of the Navy Basic Test Battery should be extended to the selection of recruits for specific shipboard training as well as for selection of recruits for formal school training.
Generating Usable Knowledge

In this study, a self-report measure of intervention usage, the Usage Rating Profile for Interventions (URP-I) is developed and empirically examined with regard to factor structure and internal consistency. Results supported that intervention usage is associated with at least 4 different constructs, and that a measure consisting of 25 items may provide a reliable index of the 4 factors. The 4 factors identified included Acceptability, Knowledge, Feasibility, and Integrity. Findings extend and integrate existing work-related items to acceptability research aimed at predicting usage. Implications, limitations, and future directions are discussed. Dans cette étude, une mesure auto-evaluative de l'application des interventions appelée « Profile de classement d'usage des interventions » (Usage Rating Profile for Interventions, URP-I) a été développée et examinée par rapport à la structure factorielle et la cohérence interne. Les résultats soutiennent l'idée selon laquelle l'emploi de l'intervention est associé à au moins quatre conceptions différentes, et qu'une mesure comprenant 25 éléments pourrait fournir un index fiable de ces quatre facteurs. Ceux-ci incluent l'acceptabilité, la connaissance, la faisabilité et l'intégrité. Les résultats élargissent et intègrent le travail existant sur l'acceptabilité visant à prévoir l'usage de ces interventions. Les implications de cette mesure, ainsi que ses limites et quelques directions futures sont élaborées dans cet article.
Hypoglycemia in Pregnant Women With Type 1 Diabetes

OBJECTIVE—In pregnancy with type 1 diabetes, we evaluated occurrence of mild and severe hypoglycemia and analyzed the influence of strict metabolic control, nausea, vomiting, and other potential predictors of occurrence of severe hypoglycemia. RESEARCH DESIGN AND METHODS—A prospective observational study of 108 consecutive pregnant women with type 1 diabetes was conducted. At 8, 14, 21, 27, and 33 weeks of gestation, patients performed self-monitored plasma glucose (SMPG) (eight/day) for 3 days and completed a questionnaire on nausea, vomiting, hypoglycemia awareness, and history of mild (managed by the patient) and severe (requiring assistance from others) hypoglycemia. RESULTS—Forty-nine (45%) women experienced 178 severe hypoglycemic events, corresponding to 5.3, 2.4, and 0.5 events/patient-year in the first, second, and third trimesters, respectively. The incidence of mild hypoglycemia was 5.5 events/patient-week in early pregnancy and decreased throughout pregnancy (P < 0.0001), regardless of presence of severe hypoglycemia. Prevalence of nausea and vomiting, mild hypoglycemia, and fraction of SMPG readings ≤3.9 mmol/l did not differ between women with and without severe hypoglycemia. A1C, median SMPG, and fluctuations in SMPG decreased during pregnancy, with no differences between women with and without severe hypoglycemia. Logistic regression analysis identified history of severe hypoglycemia the year preceding pregnancy (odds ratio 3.3 [95% CI 1.2–9.2]) and impaired awareness or unawareness (3.2 [1.2–8.2]) as independent predictors for severe hypoglycemia. CONCLUSIONS—In pregnancy with type 1 diabetes, the incidence of mild and severe hypoglycemia was highest in early pregnancy, although metabolic control was tighter in the last part of pregnancy. Predictors for severe hypoglycemia were history of severe hypoglycemia and impaired awareness.