Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of cardiac vagal outflow on complexity and fractal correlation properties of heart rate dynamics.

1. Cardiac vagal outflow is the major factor determining the magnitude of heart rate (HR) variability analysed by traditional time and frequency domain methods. New analysis techniques, such as fractal and complexity methods, have been developed to probe non-linear features in HR behaviour that may not be detectable by traditional methods. 2. We investigated the effects of vagal blockade (glycopyrrolate i.v. 5 microg kg-1 h-1 for 2 h, n = 8 vs. unmedicated control group, n = 8) and various breathing patterns (n = 12) on two non-linear measures of HR variability--detrended fluctuation analysis (DFA) and approximate entropy (ApEn)--in healthy male volunteers. 3. Glycopyrrolate decreased the mean (+/-SD) ApEn from 1.46 +/- 0.18 to 0.85 +/- 0.24 (P = 0.001 in comparison with the control group), and increased the short-term (alpha 1) and intermediate-term (alpha 2) fractal scaling exponents of DFA, alpha 1 from 0.96 +/- 0.19 to 1.43 +/- 0.29 (P = 0.003) and alpha 2 from 1.13 +/- 0.10 to 1.34 +/- 0.14 (P < 0.001). 4. Decrease in fixed respiration rate from 15 to 6 breaths min-1 increased alpha 1 from 0.83 +/- 0.25 to 1.18 +/- 0.27 (P < 0.001), but decreased alpha 2 from 0.88 +/- 0.09 to 0.45 +/- 0.17 (P < 0.001) and ApEn from 1.26 +/- 0.12 to 1.10 +/- 0.14 (P = 0.028). Rapid breathing (24 min-1) had no influence on these non-linear measures of HR variability. Hyperventilation (15 min-1, tidal volume increased voluntarily by 0.5 l) decreased alpha 1 from 0.83 +/- 0.25 to 0.66 +/- 0.28 (P = 0.002) but did not affect alpha 2 or ApEn. 5. To conclude, vagal blockade alters the fractal scaling properties of R-R intervals (alpha 1, alpha 2) and reduces the complexity (ApEn) of HR behaviour. Both the fractal and complexity measures of HR variability can also be influenced by changes in the breathing pattern.
Lexical Disambiguation using Simulated Annealing

The resolution of lexical ambiguity is important for most natural language processing tasks, and a range of computational techniques have been proposed for its solution. None of these has yet proven effective on a large scale. In this paper, we describe a method for lexical disambiguation of text using the definitions in a machine-readable dictionary together with the technique of simulated annealing. The method operates on complete sentences and attempts to select the optimal combinations of word senses for all the words in the sentence simultaneously. The words in the sentences may be any of the 28,000 headwords in Longman's Dictionary of Contemporary English (LDOCE) and are disambiguated relative to the senses given in LDOCE. Our initial results on a sample set of 50 sentences are comparable to those of other researchers, and the fully automatic method requires no hand coding of lexical entries, or hand tagging of text.
Combining Conditional Random Fields and Word Embeddings for the CHEMDNER-patents task

This paper describes our system developed for the BioCreative V CHEMDNER-patents task. The system is based on Conditional Random Field (CRF) trained with standard features used in current Named Entity Recognition (NER) systems as well as word clusters generated by the Word2Vec tool and a lexicon feature from the DINTO ontology.
A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations

Expression of the chemokine receptor CCR4 is strongly associated with trafficking of specialized cutaneous memory T helper (Th) lymphocytes to the skin. However, it is unknown whether CCR4 itself participates in the development of cutaneous Th populations. We have addressed this issue via competitive bone marrow (BM) reconstitution assays; equal numbers of BM cells from CCR4+/+ and CCR4−/− donors were allowed to develop side-by-side within RAG-1−/− hosts. Cells from both donor types developed equally well into B cells, naive CD8 T cells, naive CD4 T cells, interferon-γ+ Th1 cells, and interleukin-4+ Th2 cells. In marked contrast, circulating cutaneous memory Th cells (i.e., E-selectin ligand+ [E-lig+]) were more than fourfold more likely to be derived from CCR4+/+ donors than from CCR4−/− donors. Most of this effect resides within the CD103+ subset of the E-lig+ Th population, in which donor CCR4+/+ cells can outnumber CCR4−/− cells by >12-fold. No similar effect was observed for α4β7+ intestinal memory Th cells or CD103+/E-lig− Th cells. We conclude that CCR4 expression provides a competitive advantage to cutaneous Th cells, either by participating in their development from naive Th cells, or by preferentially maintaining them within the memory population over time.
What the success of brain imaging implies about the neural code

The success of fMRI places constraints on the nature of the neural code. The fact that researchers can infer similarities between neural representations, despite limitations in what fMRI measures, implies that certain neural coding schemes are more likely than others. For fMRI to be successful given its low temporal and spatial resolution, the neural code must be smooth at the sub-voxel and functional level such that similar stimuli engender similar internal representations. Through proof and simulation, we evaluate a number of reasonable coding schemes and demonstrate that only a subset are plausible given both fMRI’s successes and its limitations in measuring neural activity. Deep neural network approaches, which have been forwarded as computational accounts of the ventral stream, are consistent with the success of fMRI, though functional smoothness breaks down in the later network layers. These results have implications for the nature of neural code and ventral stream, as well as what can be successfully investigated with fMRI.
Reusable Key Management Technique for Secured Wireless Computer Communication

- Wireless communication is used to transfer information over short distances that is a few meters as in television remote control or long distances for thousands or millions of kilometers for radio communications. It includes GPS units, garage door openers and or garage doors, wireless computer mice, keyboards and headsets, satellite television and cordless telephones. Wireless communication in computers is an effective approach for disseminating data to a number of users. To provide secure access to data in wireless broadcast services, symmetric-key based encryption is used. symmetric-key based encryption is used to ensure that only users who own the valid keys can decrypt the data With regard to various subscriptions as the efficient key management for distributing and changing keys is in great demand for access control in computer broadcasting services . The proposed system uses the efficient key management scheme, called key tree reuse (KTR), to handle the key distribution with regard to complex subscription options and user activities. KTR has many advantages as it is scalable, efficient and secure as it lets multiple programs to share a single tree. So that the users subscribing these programs can use only minimum number of keys
Role of heparan sulfate in mediating CXCL8-induced endothelial cell migration

CXCL8 (Interleukin-8, IL-8) plays an important role in angiogenesis and wound healing by prompting endothelial cell migration. It has been suggested that heparan sulfate (HS) could provide binding sites on endothelial cells to retain and activate highly diffusible cytokines and inflammatory chemokines. In the present study, we aimed to test the hypothesis that HS is essential for enhancement of endothelial cell migration by CXCL8, and to explore the underlying mechanism by detecting the changes in expression and activity of Rho GTPases and in the organization of actin cytoskeleton after enzymatic removal of HS on human umbilical vein endothelial cells (HUVECs) by using heparinase III. Our results revealed that the wound healing induced by CXCL8 was greatly attenuated by removal of HS. The CXCL8-upregulated Rho GTPases including Cdc42, Rac1, and RhoA, and CXCL8-increased Rac1/Rho activity were suppressed by removal of HS. The polymerization and polarization of actin cytoskeleton, and the increasing of stress fibers induced by CXCL8 were also abolished by heparinase III. Taken together, our results demonstrated an essential role of HS in mediating CXCL8-induced endothelial cell migration, and highlighted the biological importance of the interaction between CXCL8 and heparan sulfate in wound healing.
An optimized transgenesis system for Drosophila using germ-line-specific φC31 integrases

Germ-line transformation via transposable elements is a powerful tool to study gene function in Drosophila melanogaster. However, some inherent characteristics of transposon-mediated transgenesis limit its use for transgene analysis. Here, we circumvent these limitations by optimizing a φC31-based integration system. We generated a collection of lines with precisely mapped attP sites that allow the insertion of transgenes into many different predetermined intergenic locations throughout the fly genome. By using regulatory elements of the nanos and vasa genes, we established endogenous sources of the φC31 integrase, eliminating the difficulties of coinjecting integrase mRNA and raising the transformation efficiency. Moreover, to discriminate between specific and rare nonspecific integration events, a white gene-based reconstitution system was generated that enables visual selection for precise attP targeting. Finally, we demonstrate that our chromosomal attP sites can be modified in situ, extending their scope while retaining their properties as landing sites. The efficiency, ease-of-use, and versatility obtained here with the φC31-based integration system represents an important advance in transgenesis and opens up the possibility of systematic, high-throughput screening of large cDNA sets and regulatory elements.
iPBA: a tool for protein structure comparison using sequence alignment strategies

With the immense growth in the number of available protein structures, fast and accurate structure comparison has been essential. We propose an efficient method for structure comparison, based on a structural alphabet. Protein Blocks (PBs) is a widely used structural alphabet with 16 pentapeptide conformations that can fairly approximate a complete protein chain. Thus a 3D structure can be translated into a 1D sequence of PBs. With a simple Needleman–Wunsch approach and a raw PB substitution matrix, PB-based structural alignments were better than many popular methods. iPBA web server presents an improved alignment approach using (i) specialized PB Substitution Matrices (SM) and (ii) anchor-based alignment methodology. With these developments, the quality of ∼88% of alignments was improved. iPBA alignments were also better than DALI, MUSTANG and GANGSTA+ in >80% of the cases. The webserver is designed to for both pairwise comparisons and database searches. Outputs are given as sequence alignment and superposed 3D structures displayed using PyMol and Jmol. A local alignment option for detecting subs-structural similarity is also embedded. As a fast and efficient ‘sequence-based’ structure comparison tool, we believe that it will be quite useful to the scientific community. iPBA can be accessed at http://www.dsimb. inserm.fr/dsimb_tools/ipba/.
A randomized controlled trial of motivational enhancement therapy (MET) for mild to moderate alcohol dependence.

OBJECTIVE This study was designed to conduct a randomized controlled trial of motivational enhancement therapy (MET) with two control conditions: nondirective reflective listening (NDRL) and no further counseling (NFC); and to conduct this study in a sample of patients with a primary diagnosis of mild to moderate alcohol dependence, in a "real-life" clinical setting. METHOD Patients with mild to moderate alcohol dependence were recruited, assessed and treated at the Community Alcohol and Drug Service of Christchurch, New Zealand. All patients received a feedback/education session before randomization to either four sessions of MET, four sessions of NDRL, or NFC. Outcome data on 122 subjects (57.4% men) were obtained 6 months following the end of treatment, by an interviewer who was blind to the treatment condition. The primary drinking outcome was unequivocal heavy drinking, defined as drinking 10 or more standard drinks six or more times in the follow-up period. Global assessment scale (GAS) measured general personal/social functioning. RESULTS Of patients treated with MET, 42.9% showed unequivocal heavy drinking compared with 62.5% of the NDRL and 65.0% of the NFC groups (p = .04). No significant differences were found for GAS score according to treatment condition. CONCLUSIONS In patients with mild to moderate alcohol dependence, MET is more effective for reducing unequivocal heavy drinking than either a feedback/education session alone or four sessions of NDRL. MET can be considered an effective "value added" counseling intervention in a real-life clinical setting. In patients with mild to moderate alcohol dependence, nondirective reflective listening provides no additional advantage over a feedback/education session alone.
Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism

The AcrA/AcrB/TolC complex spans the inner and outer membranes of Escherichia coli and serves as its major drug-resistance pump. Driven by the proton motive force, it mediates the efflux of bile salts, detergents, organic solvents, and many structurally unrelated antibiotics. Here, we report a crystallographic structure of trimeric AcrB determined at 2.9 and 3.0 angstrom resolution in space groups that allow asymmetry of the monomers. This structure reveals three different monomer conformations representing consecutive states in a transport cycle. The structural data imply an alternating access mechanism and a novel peristaltic mode of drug transport by this type of transporter.
Gaze Behavior in One-Handed Catching and Its Relation with Interceptive Performance: What the Eyes Can't Tell

In ball sports, it is usually acknowledged that expert athletes track the ball more accurately than novices. However, there is also evidence that keeping the eyes on the ball is not always necessary for interception. Here we aimed at gaining new insights on the extent to which ocular pursuit performance is related to catching performance. To this end, we analyzed eye and head movements of nine subjects catching a ball projected by an actuated launching apparatus. Four different ball flight durations and two different ball arrival heights were tested and the quality of ocular pursuit was characterized by means of several timing and accuracy parameters. Catching performance differed across subjects and depended on ball flight characteristics. All subjects showed a similar sequence of eye movement events and a similar modulation of the timing of these events in relation to the characteristics of the ball trajectory. On a trial-by-trial basis there was a significant relationship only between pursuit duration and catching performance, confirming that keeping the eyes on the ball longer increases catching success probability. Ocular pursuit parameters values and their dependence on flight conditions as well as the eye and head contributions to gaze shift differed across subjects. However, the observed average individual ocular behavior and the eye-head coordination patterns were not directly related to the individual catching performance. These results suggest that several oculomotor strategies may be used to gather information on ball motion, and that factors unrelated to eye movements may underlie the observed differences in interceptive performance.
The effect of rocket plume contamination on the optical properties of transmitting and reflecting materials.

The preliminary results of plume contamination from a 5-pound thrust single-doublet, bipropellant rocket engine on the transmittance of quartz and the reflectance of a silicon monoxide overcoated aluminum mirror have been presented. Changes in quartz transmittance were found to be significant and were due to both absorption and scattering effects. Contaminant absorption effects were predominant at the short wavelengths and scattering effects were greatest in the visible wavelengths. Measured changes in mirror reflectance were due primarily to contaminant absorption. Scattering effects were found to be as much as 9% of the total reflected energy from the mirror. There were no noticeable chemical or erosion effects on either the quartz or the front surface mirror.
Competition in the Chemostat: Some Remarks

1 Review of competition for a single substrate Paul Walt-man's chemostat-related work has had a large impact in population biology , ecology and bio-engineering. It has motivated and inspired the work of many other authors, including us. It seems appropriate to point out a major open problem which remains unresolved after more than thirty years and to touch on some other issues related to bacterial ecology in the chemostat. The basic equations for mixed culture competition in the chemostat for a single growth-limiting substrate are given by [8, 26, 29]: (1.1)
TanDEM-X DSM uncertainty measures and demonstrations

SAR interferometry is a well-known technique to produce digital surface models (DSM). In the global scale, the quality of these models significantly increased with the use of bistatic systems as for the TanDEM-X mission. DSM uncertainty can be measured in two scales: a global and a local one. A global scale analysis involves measures for the complete take, characterizing the whole correctness with a single parameter. A local scale analysis enters instead in the single elevation model cell, evaluating the quality obtained by different terrains and media present in the take. A coherence analysis is a typical measure for InSAR models. Globally, a simple average gives an overall quality measure hint. Locally, it provides a measure of the DSM pixel height error. Unfortunately, this measure lacks in several aspects as not considering unwrapping errors and not being valid for certain types of scattering. In this paper, various strategies for assessing elevation accuracy methods and demonstrate the different capabilities of the bistatic TanDEM-X system are proposed for variegated terrain types.
Analog versus Discrete Neural Networks

We show that neural networks with three-times continuously differentiable activation functions are capable of computing a certain family of n-bit Boolean functions with two gates, whereas networks composed of binary threshold functions require at least Ω(log n) gates. Thus, for a large class of activation functions, analog neural networks can be more powerful than discrete neural networks, even when computing Boolean functions.
An Agent-Based System for Sensor Cloud Management

An embedded sensor network is a network of embedded computers deployed in the physical world that interacts with the environment. Each embedded computer, commonly referred to as a sensor node, is a physically small and relatively inexpensive computer that has one or more sensors. These sensor nodes are often networked, allowing them to communicate and cooperate with each other to monitor the environment[1]. In recent years, embedded sensor networks have been gaining increasing attention, both from the academia and industry, because of their potential to be a novel and practical solution across multiple areas such as industrial automation, asset management, environmental monitoring, transportation business, and healthcare. Typically, an embedded sensor network is controlled by its own applications that can access the sensor nodes within the network. On the other hand, the sensor nodes cannot be easily accessed by applications outside of the network. Moreover, even within the same network, different applications might encounter a race condition when they are trying to access a sensor node simultaneously. Existing research works of embedded sensor networks focus on data processing[2], routing[3, 4], power management[5], clock synchronization[6-8], localization[9, 10], operating system[11, 12], and programming[13, 14]. However, not much research has been done with a focus on the management of sensor nodes.
Implicit test generation for behavioral VHDL models

This paper proposes a behavioral-level test pattern generation algorithm for behavioral VHDL descriptions. The proposed approach is based on the comparison between the implicit description of the fault-free behavior and the faulty behavior, obtained through a new behavioral fault model. The paper will experimentally show that the test patterns generated at the behavioral level provide a very high stuck-at fault coverage when applied to different gate-level implementations of the given VHDL behavioral specification. Gate-level ATPGs applied on these same circuits obtain lower fault coverage, in particular when considering circuits with hard to detect faults.
Experiences with USAR mobile interfaces: The need for persistent geo-localized information

Urban search and rescue (USAR) missions are unique and unpredictable. Communication and coordination is difficult, with high-level actors (e.g. mission commander) lacking local terrain knowledge while low-level actors (e.g. robot operators, in-field rescuers) lack global situation awareness (SA). In-field actors have high mobility and a direct view of the field, but so far they could communicate this SA almost exclusively through radio. Unfortunately, words are imprecise and unorganized, and thus not easily analyzable and retrievable. As part of the NIFTi1 project, we developed mobile applications to help in-field actors share their SA with the rescue team. We also performed high-fidelity USAR simulations and missions at fire fighting training sites and disaster areas. We discovered a need for persistent geo-localized information and propose a novel system architecture that integrates pictures taken from robots and from in-field rescuers into the existing systems at the command post.
A Theory of Macroprudential Policies in the Presence of Nominal Rigidities

We propose a theory of monetary policy and macroprudential interventions in financial markets. We focus on economies with nominal rigidities in goods and labor markets and subject to constraints on monetary policy, such as the zero lower bound or fixed exchange rates. We identify an aggregate demand externality that can be corrected by macroprudential interventions in financial markets. Ex post, the distribution of wealth across agents affects aggregate demand and output. Ex ante, however, these effects are not internalized in private financial decisions. We provide a simple formula for the required financial interventions that depends on a small number of measurable sufficient statistics. We also characterize optimal monetary policy. We extend our framework to incorporate pecuniary externalities, providing a unified approach to both externalities. Finally, we provide a number of applications which illustrate the relevance of our theory.
On applying variable error correction technique to the design of bounded distance routing protocol for underwater wireless sensors networks

Variable channel conditions in underwater channels have great effects on total energy consumption. This variability in channel conditions is ignored in many networking protocols. In this paper we have investigated the effects of variable channel conditions in calculating the optimum per hop distance (i.e. optimum number of relays between sender and receiver) in bounded distance routing protocols. Based on this investigation we have applied adaptive variable error correction technique to minimize the effect of variable channel conditions in calculating the optimum number of relays between sender and receiver. The result shows less deviations from the optimum number of relays when we use variable error correction technique.