Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute monocytic or myelomonocytic leukemia with balanced chromosome translocations to band 11q23 after therapy with 4-epi-doxorubicin and cisplatin or cyclophosphamide for breast cancer.

PURPOSE To report five cases of acute monocytic or myelomonocytic leukemia after chemotherapy with 4-epidoxorubicin for breast cancer and to evaluate the risk of leukemia after the use of this drug. PATIENTS AND METHODS One hundred fifty-seven patients with advanced breast cancer were randomized to either 4-epi-doxorubicin plus cisplatin or 4-epi-doxorubicin alone. An additional 203 patients were treated prospectively with 4-epi-doxorubicin alone. All were observed closely for leukemic complications. RESULTS Three patients from the randomized study developed leukemia; all were in the subgroup of 74 patients who received 4-epi-doxorubicin plus cisplatin, whereas no leukemia was observed among the remaining 83 patients in the randomized study or among the additional 203 patients who were treated prospectively with 4-epi-doxorubicin alone (P = .023, log-rank test). In the subgroup of 74 patients who were treated with 4-epi-doxorubicin plus cisplatin, the cumulative risk of leukemia was 16.0% +/- 9.9% (mean +/- SE) 33 months after the start of therapy; the relative risk was 668 (95% confidence interval [Cl], 138 to 1,953). Two other cases of acute monocytic and myelomonocytic leukemia were observed after 4-epi-doxorubicin plus alkylating agents were administered for breast cancer. Three of five cases of leukemia presented balanced translocations to chromosome band 11q23 and two, loss of a whole chromosome no. 7 or its long arm. CONCLUSIONS 4-epi-doxorubicin is leukemogenic, and the leukemias are often acute monocytic or myelomonocytic with balanced chromosome translocations to band 11q23, such as in the leukemias after therapy with the epipodophyllotoxins. Furthermore, our results suggest a synergistic effect in leukemogenesis between 4-epi-doxorubicin targeting DNA-topoisomerase II and directly genotoxic drugs such as cisplatin or alkylating agents.
Efficient Operation of Wireless Packet Networks Using Network Coding

The marriage of network coding and wireless packet networks is a natural and attractive one. So, despite network coding being a still nascent field, a considerable body of work on this subject already exists. In this paper, we give a brief overview of this work and hope, thereby, to provide the reader with a firm theoretical basis from which practical implementations and theoretical extensions can be developed.
Learning Perceptually-Grounded Semantics in The L0 Project

A method is presented for acquiring perceptually-grounded semantics for spatial terms in a simple visual domain, as a part of the L0 miniature language acquisition project. Two central problems in this learning task are (a) ensuring that the terms learned generalize well, so that they can be accurately applied to new scenes, and (b) learning in the absence of explicit negative evidence. Solutions to these two problems are presented, and the results discussed.
Probability of Partially Decoding Network-Coded Messages

In the literature, there exist analytical expressions for the probability of a receiver decoding a transmitted source message that has been encoded using random linear network coding. In this letter, we look into the probability that the receiver will decode at least a fraction of the source message, and present an exact solution to this problem for both non-systematic and systematic network coding. Based on the derived expressions, we investigate the potential of these two implementations of network coding for information-theoretic secure communication and progressive recovery of data.
Job strain and psychotropic drug use among white-collar workers

The main objective of this study was to measure the association between simultaneous exposure to high psychological demand and low decision latitude at work and the use of psychotropic drugs among white-collar workers. A second objective was to determine whether social support at work modified this association. A cross-sectional study was performed that included 2786 workers from the public sector in the Greater Quebec City area. A self-administered questionnaire was used in order to evaluate psychological demand, decision latitude and social support at work. Psychotropic drug use was measured over a period of 2 days. The prevalence of psychotropic drug use among the participants was found to be 3.9%, even though 20.5% were exposed to job strain. The association between job strain and psychotropic drug use, after adjustment for social support at work, age, gender, education, family income, employment status, occupation, stressful life events, cigarette smoking, alcohol consumption and physical activity, w.
Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy

Heterozygous loss-of-function mutations in the α subunit of the type I voltage-gated sodium channel NaV1.1 cause severe myoclonic epilepsy in infancy (SMEI), an infantile-onset epileptic encephalopathy characterized by normal development followed by treatment-refractory febrile and afebrile seizures and psychomotor decline. Mice with SMEI (mSMEI), created by heterozygous deletion of NaV1.1 channels, develop seizures and ataxia. Here we investigated the temperature and age dependence of seizures and interictal epileptiform spike-and-wave activity in mSMEI. Combined video-EEG monitoring demonstrated that mSMEI had seizures induced by elevated body core temperature but wild-type mice were unaffected. In the 3 age groups tested, no postnatal day (P)17–18 mSMEI had temperature-induced seizures, but nearly all P20–22 and P30–46 mSMEI had myoclonic seizures followed by generalized seizures caused by elevated core body temperature. Spontaneous seizures were only observed in mice older than P32, suggesting that mSMEI become susceptible to temperature-induced seizures before spontaneous seizures. Interictal spike activity was seen at normal body temperature in most P30–46 mSMEI but not in P20–22 or P17–18 mSMEI, indicating that interictal epileptic activity correlates with seizure susceptibility. Most P20–22 mSMEI had interictal spike activity with elevated body temperature. Our results define a critical developmental transition for susceptibility to seizures in SMEI, demonstrate that body temperature elevation alone is sufficient to induce seizures, and reveal a close correspondence between human and mouse SMEI in the striking temperature and age dependence of seizure frequency and severity and in the temperature dependence and frequency of interictal epileptiform spike activity.
Reducing the Educational Gap: Good Results in Vulnerable Groups

Abstract We analyse the educational performance of a group of schools that serve socially vulnerable children and that have implemented distinguishable teaching and management methods. Conditioned to students, school characteristics, selection criteria and resources, robust performance measures show statistically significant economically relevant differences in favour of these schools. Whilst only a small part of this difference can be explained with simple management practices that we isolate statistically, there remain an important residual we can associate with distinctive practices identified in the qualitative literature as present in successful schools.
Bounding the effectiveness of temporal redundancy in fault-tolerant real-time scheduling under error bursts

Reliability is a key requirement in many distributed real-time systems deployed in safety and mission critical applications, and temporal redundancy is a widely employed strategy towards guaranteeing it. The temporal redundancy approach is typically based on task re-executions in form of entire tasks, task alternates or, check-pointing blocks, and each of the re-execution strategies have different impacts on the Fault Tolerance feasibility (FT-feasibility) of the system, which is traditionally defined as the existence of a schedule that guarantees timeliness of all tasks under a specified fault hypothesis. In this paper, we propose the use of resource augmentation to quantify the FT-feasibility of real-time task sets and use it to derive limits on the effectiveness of temporal redundancy in fault-tolerant real-time scheduling under error bursts of bounded lengths. We derive the limits for the general case, and then show that for the specific case when the error burst length is no longer than half the shortest deadline, the lower limit on the effectiveness of temporal redundancy is given by the resource augmentation bound 2, while, the corresponding upper-limit is 6. Our proposed approach empowers a system designer to quantify the effectiveness of a particular implementation of temporal redundancy.
Detection of fetal subchromosomal abnormalities by sequencing circulating cell-free DNA from maternal plasma.

BACKGROUND The development of sequencing-based noninvasive prenatal testing (NIPT) has been largely focused on whole-chromosome aneuploidies (chromosomes 13, 18, 21, X, and Y). Collectively, they account for only 30% of all live births with a chromosome abnormality. Various structural chromosome changes, such as microdeletion/microduplication (MD) syndromes are more common but more challenging to detect. Recently, several publications have shown results on noninvasive detection of MDs by deep sequencing. These approaches demonstrated the proof of concept but are not economically feasible for large-scale clinical applications. METHODS We present a novel approach that uses low-coverage whole genome sequencing (approximately 0.2×) to detect MDs genome wide without requiring prior knowledge of the event's location. We developed a normalization method to reduce sequencing noise. We then applied a statistical method to search for consistently increased or decreased regions. A decision tree was used to differentiate whole-chromosome events from MDs. RESULTS We demonstrated via a simulation study that the sensitivity difference between our method and the theoretical limit was <5% for MDs ≥9 Mb. We tested the performance in a blinded study in which the MDs ranged from 3 to 40 Mb. In this study, our algorithm correctly identified 17 of 18 cases with MDs and 156 of 157 unaffected cases. CONCLUSIONS The limit of detection for any given MD syndrome is constrained by 4 factors: fetal fraction, MD size, coverage, and biological and technical variability of the event region. Our algorithm takes these factors into account and achieved 94.4% sensitivity and 99.4% specificity.
A Progressive Clustering Algorithm to Group the XML Data by Structural and Semantic Similarity

Since the emergence in the popularity of XML for data representation and exchange over the Web, the distribution of XML documents has rapidly increased. It has become a challenge for researchers to turn these documents into a more useful information utility. In this paper, we introduce a novel clustering algorithm PCXSS that keeps the heterogeneous XML documents into various groups according to their similar structural and semantic representations. We develop a global criterion function CPSim that progressively measures the similarity between a XML document and existing clusters, ignoring the need to compute the similarity between two individual documents. The experimental analysis shows the method to be fast and accurate.
Equivalence between Kaluza Klein modes of gravitinos and goldstinos in brane induced supersymmetry breaking

We identify the goldstino fields that give mass to the Kaluza Klein modes of five dimensional supergravity, when supersymmetry breaking is induced by brane effects. We then proof the four dimensional Equivalence Theorem that, in renormalizable gauges, allows for the replacement of Kaluza Klein modes of helicity $\pm1/2$ gravitinos in terms of goldstinos. Finally we identify the five dimensional renormalizable gauge fixing that leads to the Equivalence Theorem.
Measuring Offender Progress in Treatment Using the Client Assessment Inventory

The accurate and reliable assessment of client psychological and cognitive change during correctional substance abuse treatment has gained increasing importance during the past decade as criminal justice systems seek to evaluate and understand those treatment elements associated with long-term change. The Client Assessment Inventory (CAI) is a self-report instrument for measuring client change during treatment across 14 cognitive and behavioral domains. The reliability and internal consistency of the CAI, as adapted for use in criminal justice settings, were examined with data gathered from 1,170 offenders. The research addressed the utility of the CAI for different subpopulations of offenders (e.g., race/ethnicity, gender) across a variety of correctional treatment settings. Overall, the data support the use of the CAI as a consistent, reliable, and easily administered instrument for measuring client performance and progress in treatment in both therapeutic community (TC) and non-TC correctional treatment settings.
Industry’s Electrification and Role in the Future Electricity System

Trends visible today suggest that a transformation of industrial firms’ use of electricity, and a change in their role in the electricity system, could take place as a part of a long-term transition towards a low-carbon Swedish economy. The shape of these changes remains highly uncertain, but electrification, flexible electricity use, and emerging roles in the electricity system for industrial consumers are interdependent developments and should be investigated from a holistic perspective where possible. Swedish industry is relatively energy intensive, and has stood for roughly 37% of the country’s electricity use for a decade. The Swedish Energy Agency’s Vivace scenario suggests that this share could expand, despite improved efficiency, to 49% by 2050. The increased use of electricity to reduce greenhouse gas emissions and take advantage of market conditions would play out differently in different sectors, and depending on the development of different technologies. However large-scale opportunities may exist in the long-term, such as using electrolysis to produce hydrogen for replacing coke in the iron and steel industry and as a feedstock in the petrochemical industry. Smaller-scale but still important options for electrification include electric/hybrid boilers in the pulp and paper industry and a variety of electro-thermal technologies for heating and drying. Increased use of electricity in industry is likely to go hand-in-hand with increasingly flexible use of electricity. In some cases, such as the production of hydrogen or process media, this flexibility will be in-built since the storable energy carriers create new production planning options. In other cases, new approaches to planning, process design, and the use of automation may allow firms to match electricity use to favourable market conditions. The expected high penetration of intermittent renewable electricity in the power system may create incentives for this flexibility. These incentives should appear on the wholesale market, in the form of high- and low-price periods. They may also appear via new capacity markets, or through markets for new system services needed to support stability in both transmission and distribution networks. The frameworks and regulations needed to create these markets are not yet in place, and firms will also need to develop technical and management capabilities to take advantage of them.
Diagnosis and treatment of melamine‐associated urinary calculus complicated with acute renal failure in infants and young children

Background Infants in some areas of China developed urinary lithiasis after being fed with powdered milk that was tainted with melamine in 2008 and very small proportion of the infants developed acute renal failure caused by urinary tract calculus obstruction. The aim of this article was to summarize clinical characteristics, diagnosis and treatment of infants with urinary calculus and acute renal failure developed after being fed with melamine tainted formula milk. Methods Data of infant patients with urinary calculus and acute renal failure due to melamine tainted formula milk admitted to the Beijing Children's Hospital Affiliated to the Capital Medical University and the Xuzhou Children's Hospital in 2008 were used to analyze the epidemiological characteristics, clinical manifestations, imaging features as well as effects of 4 types of therapies. Results All the 34 infants with urinary calculus were complicated with acute renal failure, their blood urea nitrogen (BUN) was (24.1±8.2) mmol/L and creatinine (Cr) was (384.2±201.2) &mgr;mol/L. The chemical analysis on the urinary calculus sampled from 15 of the infants showed that the calculus contained melamine and acidum uricum. The time needed for the four types of therapies for returning Cr to normal was (3.5±1.9) days for cystoscopy group, (2.7±1.1) days for lithotomy group, (3.8±2.3) days for dialysis group, and (2.7±1.6) days for medical treatment group, which had no statistically significant difference (P=0.508). Renal failure of all the 34 infants was relieved within 1 to 7 days, averaging (3.00±1.78) days. Conclusions Melamine tainted formula milk may cause urinary calculus and obstructive acute renal failure. It is suggested that firstly the patients with urinary calculus complicated with acute renal failure should be treated with dialysis or medication to correct electrolyte disturbance, in particular hyperkalemia, and then relieve the obstruction with available medical and surgical methods as soon as possible. It was observed that the short‐term prognosis was satisfactory.
Single-Item Vs Multiple-Item Measures of Health-Related Quality of Life

Many survey instruments measure health-related quality of life. Researchers can choose from instruments ranging in length from one to several hundred items. A small sample of 35 chronically ill adults self-administered the Short-form General Health Survey of the Medical Outcomes Study, a 20-item health-related quality-of-life measure with established reliability and validity. One specific item on the MOS questionnaire can serve as a single-item measure of health-related quality of life. This one item correlated positively and significantly with the over-all score for health-related quality of life. The results of this analysis support the use of this single-item measure of health-related quality of life when multiple-item instruments are not suitable due to limitations of resources or sample size.
Bringing it all Together: The Multiple Origins, Skills, and Environmental Supports of Early Literacy

In the final three decades of the 20th century one of the exciting developments in the field of educational research was the emergence of theoretically grounded empirical research into the origins of literacy in the preschool years. This work has led to a growing relationship between two fields that previously had existed in relative isolation from each other: reading research and early childhood education. The result of this research has been the investigation of the emergence of literacy, and environmental factors that support its emergence, and a new awareness of the relevance of literacy for early childhood educators. A manifestation of the potential of these converging efforts was the release of a joint position statement on early literacy by the National Association of Educators of Young Children and the International Reading Association in 1998. The investigation of early literacy has resulted in findings of considerable importance for social policy because it made evident that, even before children commence formal instruction in reading and writing, they display differences that mirror some of the divisions in our society, with children from less economically advantaged and non-English speaking homes being at a disadvantage (Zill, Collins, West, & Hausken, 1995). These early differences are remarkably stable as they have consistently been found in cross-sectional examinations of children aged 9, 13, and 17 on national assessments of literacy (Campbell, Hombo, & Mazzeo, 2000, p. 33). Longitudinal studies also provide evidence of considerable consistency within individual children from first grade to the later elemen-
Stakeholder Perspectives About Marine Oil Spill Response Objectives: A Comparative Q Study of Four Regions

Marine oil spills can cause major social, economic, and ecological disruptions. Spill response managers must weigh different options and objectives when deciding what to do. We investigated the ways in which preferences for spill response objectives vary among those who are responsible for oil spill contingency planning and response in Buzzards Bay, Delaware Bay, San Francisco Bay, and Washington State regions. We begin this paper with a discussion of the research method used in the study: the Q method. In Buzzards Bay, Delaware Bay, and San Francisco Bay three perspectives were identified in each case. In Washington State, two perspectives were identified. An analysis of the 11 case-specific perspectives reveals that they can be described by four ‘composite’ perspectives that describe how different stakeholders prioritize spill response objectives. These four perspectives are compared on several themes, including the emphasis they placed on mitigating economic impacts, protecting health and safety, mitigating ecological impacts, implementing a coordinated and timely response, addressing the needs and concerns of the affected public/communities, gaining public support for the response, mitigating cultural impacts, and mitigating social nuisance impacts. The implications for spill response planning and spill response evaluation are discussed.
Holland Codes and 16PF Global Factors: Sixty-Nine Samples

Global Factor scores from Cattell's Sixteen Personality Factor Questionnaire (16PF) were correlated with Holland codes using mean 16PF profiles from 69 occupational groups as data. Unlike prior studies, this study features occupational groups as the unit of analysis. Two analyses were done to test expectations, (a) 16PF scores would significantly discriminate among Holland types and (b) 16PF mean scores for each type would differ from the population mean in a direction consistent with prior research. Results met expectations on each analysis. Findings for two of the Global Factors (Anxiety and Self-control) warranted special comment. Interpretations were offered and implications discussed.
Mapping of Ice Motion in Antarctica Using Synthetic-Aperture Radar Data

Ice velocity is a fundamental parameter in studying the dynamics of ice sheets. Until recently, no complete mapping of Antarctic ice motion had been available due to calibration uncertainties and lack of basic data. Here, we present a method for calibrating and mosaicking an ensemble of InSAR satellite measurements of ice motion from six sensors: the Japanese ALOS PALSAR, the European Envisat ASAR, ERS-1 and ERS-2, and the Canadian RADARSAT-1 and RADARSAT-2. Ice motion calibration is made difficult by the sparsity of in-situ reference points and the shear size of the study area. A sensor-dependent data stacking scheme is applied to reduce measurement uncertainties. The resulting ice velocity mosaic has errors in magnitude ranging from 1 m/yr in the interior regions to 17 m/yr in coastal sectors and errors in flow direction ranging from less than 0.5 in areas of fast flow to unconstrained direction in sectors of slow motion. It is important to understand how these mosaics are calibrated to understand the inner characteristics of the velocity products as well as to plan future InSAR acquisitions in the Antarctic. As an example, we show that in broad sectors devoid of ice-motion control, it is critical to operate ice motion mapping on a large scale to avoid pitfalls of calibration uncertainties that would make it difficult to obtain quality products and especially construct reliable time series of ice motion needed to detect temporal changes.