Miracle-dz/UniFAR-FTUs huggingface dataset:
High Level Event Identification in Social Media

The rapid growth of information technology along with variety of digital data generation provides an opportunity to better understand human dynamics. However, knowing and obtaining complete information about events and activities that happen, becomes a complicated task in Natural Language Processing (NLP) and location based social networks. In this research, we introduce a new approach to recognize events in social media. On the basis of the approach, we demonstrate an event explorer system which models event topics using a latent Dirichlet allocation (LDA) and classifies the events by various features. The preliminary result is introduced on certain web-sources. The study aims at improving automatic event recognition task from social media.
The Grapevine Uncharacterized Intrinsic Protein 1 (VvXIP1) Is Regulated by Drought Stress and Transports Glycerol, Hydrogen Peroxide, Heavy Metals but Not Water

A MIP (Major Intrinsic Protein) subfamily called Uncharacterized Intrinsic Proteins (XIP) was recently described in several fungi and eudicot plants. In this work, we cloned a XIP from grapevine, VvXIP1, and agrobacterium-mediated transformation studies in Nicotiana benthamiana revealed that the encoded aquaporin shows a preferential localization at the endoplasmic reticulum membrane. Stopped-flow spectrometry in vesicles from the aqy-null yeast strain YSH1172 overexpressing VvXIP1 showed that VvXIP1 is unable to transport water but is permeable to glycerol. Functional studies with the ROS sensitive probe CM-H2DCFDA in intact transformed yeasts showed that VvXIP1 is also able to permeate hydrogen peroxide (H2O2). Drop test growth assays showed that besides glycerol and H2O2, VvXIP1 also transports boric acid, copper, arsenic and nickel. Furthermore, we found that VvXIP1 transcripts were abundant in grapevine leaves from field grown plants and strongly repressed after the imposition of severe water-deficit conditions in potted vines. The observed downregulation of VvXIP1 expression in cultured grape cells in response to ABA and salt, together with the increased sensitivity to osmotic stress displayed by the aqy-null yeast overexpressing VvXIP1, corroborates the role of VvXIP1 in osmotic regulation besides its involvement in H2O2 transport and metal homeostasis.
Novel smart sensor glove for arthritis rehabiliation

Rheumatoid Arthritis (RA) is a disease which attacks the synovial tissue lubricating skeletal joints. This systemic condition affects the musculoskeletal system, including bones, joints, muscles and tendons that contribute to loss of function and Range of Motion (ROM). Traditional measurement of arthritis requires labour intensive personal examination by medical staff which through their objective measures may hinder the enactment and analysis of arthritis rehabilitation. This paper presents the development of a smart glove to facilitate this rehabilitative process through the integration of sensors, processors and wireless technology to empirically measure ROM. The Tyndall/University of Ulster glove uses a combination of 20 bend sensors, 16 tri-axial accelerometers and 11 force sensors to detect joint movement. All sensors are placed on a flexible PCB to provide high levels of flexibility and sensor stability. The system operation means that the glove does not require calibration for each glove wearer.
Transactional memory coherence and consistency

In this paper, we propose a new shared memory model: transactional memory coherence and consistency (TCC). TCC provides a model in which atomic transactions are always the basic unit of parallel work, communication, memory coherence, and memory reference consistency. TCC greatly simplifies parallel software by eliminating the need for synchronization using conventional locks and semaphores, along with their complexities. TCC hardware must combine all writes from each transaction region in a program into a single packet and broadcast this packet to the permanent shared memory state atomically as a large block. This simplifies the coherence hardware because it reduces the need for small, low-latency messages and completely eliminates the need for conventional snoopy cache coherence protocols, as multiple speculatively written versions of a cache line may safely coexist within the system. Meanwhile, automatic, hardware-controlled rollback of speculative transactions resolves any correctness violations that may occur when several processors attempt to read and write the same data simultaneously. The cost of this simplified scheme is higher interprocessor bandwidth. To explore the costs and benefits of TCC, we study the characteristics of an optimal transaction-based memory system, and examine how different design parameters could affect the performance of real systems. Across a spectrum of applications, the TCC model itself did not limit available parallelism. Most applications are easily divided into transactions requiring only small write buffers, on the order of 4-8 KB. The broadcast requirements of TCC are high, but are well within the capabilities of CMPs and small-scale SMPs with high-speed interconnects.
An LTCL Filter for Three-Phase Grid-Connected Converters

This paper presents a new high-order filter for three-phase grid-connected voltage source converters (VSCs) named the inductor-trap-capacitor-inductor (LTCL) filter, in which multiple LC trap filters are inserted in parallel with the branch of the capacitor in the traditional LCL filter to compose multiple series resonant circuits at the selected frequencies. Particularly, the LTCL filter can attenuate the harmonic currents around the multiples of switching frequencies and guarantee -60 dB/decade attenuation in the high-frequency band, leading to a decrease of the total inductance and volume. Furthermore, within half of the switching frequency range, an LTCL -filter-based grid-connected VSC has almost the same frequency-response characteristic as that with the traditional LCL filter. That is to say, the LTCL filter does not bring any extra control difficulties. The basic parameter selection criteria and the parameter design procedure of the LTCL filter are introduced. Moreover, the sensitivity analysis of the LTCL filter is analyzed and discussed in detail. The comparative analysis and discussion considering the LCL filter, the LLCL filter, the multituned traps filter, and the proposed LTCL filter, have been presented and evaluated through the experiments on a 65-kW three-phase grid-connected VSC prototype.
Collaborative Wakeup in Clustered Ad Hoc Networks

Clustering in wireless ad hoc networks has shown to be a promising technique to ensure the scalability and efficiency of various communication protocols. Since stations in these networks are usually equipped with batteries as the power source, it is critical to ensure the energy efficiency of a clustering scheme. The Quorum-based Power Saving (QPS) protocols are widely studied over the past years, as they render extensive energy conservation comparing to the IEEE 802.11 Power Saving (PS) mode. However, most existing QPS protocols adopt a symmetric design where each pair of stations in a network are guaranteed to discover each other. Observing that in clustered environments there is no need to insist on all-pair neighbor discovery, we propose an Asymmetric Cyclic Quorum (ACQ) system. The ACQ system guarantees the neighbor discovery between each member node and the clusterhead in a cluster, and between clusterheads in the network. We show that by taxing slightly more energy consumption on the clusterhead, the average energy consumption of stations in a cluster can reduce substantially than can be achieved by traditional QPS protocols. A novel construction scheme is proposed in this work, which assembles the ACQ system in O(1) time. The constructing scheme is adaptive. Stations in a cluster can adjust their awake/sleep ratio collaboratively to strike the balance between energy efficiency and delay under various cluster conditions. Simulation results show that the ACQ system outperforms the previous studies up to 52% in energy efficiency, while introducing no extra worst-case latency.
Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study.

BACKGROUND Evidence suggests that the consumption of anthocyanin-rich foods beneficially affects cardiovascular health; however, the absorption, distribution, metabolism, and elimination (ADME) of anthocyanin-rich foods are relatively unknown. OBJECTIVE We investigated the ADME of a (13)C5-labeled anthocyanin in humans. DESIGN Eight male participants consumed 500 mg isotopically labeled cyanidin-3-glucoside (6,8,10,3',5'-(13)C5-C3G). Biological samples were collected over 48 h, and (13)C and (13)C-labeled metabolite concentrations were measured by using isotope-ratio mass spectrometry and liquid chromatography-tandem mass spectrometry. RESULTS The mean ± SE percentage of (13)C recovered in urine, breath, and feces was 43.9 ± 25.9% (range: 15.1-99.3% across participants). The relative bioavailability was 12.38 ± 1.38% (5.37 ± 0.67% excreted in urine and 6.91 ± 1.59% in breath). Maximum rates of (13)C elimination were achieved 30 min after ingestion (32.53 ± 14.24 μg(13)C/h), whereas (13)C-labeled metabolites peaked (maximum serum concentration: 5.97 ± 2.14 μmol/L) at 10.25 ± 4.14 h. The half-life for (13)C-labeled metabolites ranged between 12.44 ± 4.22 and 51.62 ± 22.55 h. (13)C elimination was greatest between 0 and 1 h for urine (90.30 ± 15.28 μg/h), at 6 h for breath (132.87 ± 32.23 μg/h), and between 6 and 24 h for feces (557.28 ± 247.88 μg/h), whereas the highest concentrations of (13)C-labeled metabolites were identified in urine (10.77 ± 4.52 μmol/L) and fecal samples (43.16 ± 18.00 μmol/L) collected between 6 and 24 h. Metabolites were identified as degradation products, phenolic, hippuric, phenylacetic, and phenylpropenoic acids. CONCLUSION Anthocyanins are more bioavailable than previously perceived, and their metabolites are present in the circulation for ≤48 h after ingestion. This trial was registered at clinicaltrials.gov as NCT01106729.
Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion*

SNARE proteins catalyze many forms of biological membrane fusion, including Ca2+-triggered exocytosis. Although fusion mediated by SNAREs generally involves proteins anchored to each fusing membrane by a transmembrane domain (TMD), the role of TMDs remains unclear, and previous studies diverge on whether SNAREs can drive fusion without a TMD. This issue is important because it relates to the question of the structure and composition of the initial fusion pore, as well as the question of whether SNAREs mediate fusion solely by creating close proximity between two membranes versus a more active role in transmitting force to the membrane to deform and reorganize lipid bilayer structure. To test the role of membrane attachment, we generated four variants of the synaptic v-SNARE synaptobrevin-2 (syb2) anchored to the membrane by lipid instead of protein. These constructs were tested for functional efficacy in three different systems as follows: Ca2+-triggered dense core vesicle exocytosis, spontaneous synaptic vesicle exocytosis, and Ca2+-synaptotagmin-enhanced SNARE-mediated liposome fusion. Lipid-anchoring motifs harboring one or two lipid acylation sites completely failed to support fusion in any of these assays. Only the lipid-anchoring motif from cysteine string protein-α, which harbors many lipid acylation sites, provided support for fusion but at levels well below that achieved with wild type syb2. Thus, lipid-anchored syb2 provides little or no support for exocytosis, and anchoring syb2 to a membrane by a TMD greatly improves its function. The low activity seen with syb2-cysteine string protein-α may reflect a slower alternative mode of SNARE-mediated membrane fusion.
Scalable Monitoring of Student Interaction Indicators in Exploratory Learning Environments

We present and evaluate a web-based architecture for monitoring student-system interaction indicators in Exploratory Learning Environments (ELEs),using as our case study a microworld for secondary school algebra. We discuss the challenging role of teachers in exploratory learning settings and motivate the need for visualisation and notification tools that can assist teachers in focusing their attention across the class and inform teachers' interventions. We present an architecture that can support such Teacher Assistance tools and demonstrate its scalability to allow concurrent usage by thousands of users (students and teachers).
Searches for HCl and HF in comets 103P/Hartley 2 and C/2009 P1 (Garradd) with the Herschel Space Observatory

Context. Hydrogen chloride (HCl) and hydrogen fluoride (HF) are expected to be the main reservoirs of fluorine and chlorine over a wide range of conditions, wherever hydrogen is predominantly molecular. They are found to be strongly depleted in dense molecular clouds, suggesting freeze-out onto grains in such cold environments. We can then expect that HCl and HF were also the major carriers of Cl and F in the gas and icy phases of the outer solar nebula, and were incorporated into comets. Aims. We aimed to measure the HCl and HF abundances in cometary ices as they can provide insights on the halogen chemistry in the early solar nebula. Methods. We searched for the J(1−0) lines of HCl and HF at 626 and 1232 GHz, respectively, using the Heterodyne Instrument for the Far-Infrared (HIFI) onboard the Herschel Space Observatory. HCl was searched for in comets 103P/ Hartley 2a nd C/2009 P1 (Garradd), whereas observations of HF were conducted in comet C/2009 P1 (Garradd). In addition, observations of H2 Oa nd H2 18 O lines were performed in C/2009 P1 (Garradd) to measure the H2O production rate at the time of the HCl and HF observations. Three lines of CH3OH were serendipitously observed in the HCl receiver setting. Results. HCl is not detected, whereas a marginal (3.6-σ) detection of HF is obtained. The upper limits for the HCl abundance relative to water are 0.011% and 0.022%, for comet 103P/ Hartley 2a nd C/2009 P1 (Garradd), respectively, showing that HCl is depleted with respect to the solar Cl/O abundance by a factor more than 6 +6 −3 in 103P/Hartley 2, where the error is related to the uncertainty in the chlorine solar abundance. The marginal HF detection obtained in C/2009 P1 (Garradd) corresponds to an HF abundance relative to water of (1.8 ± 0.5) × 10 −4 , which is approximately consistent with a solar photospheric F/O abundance. The inferred water production rate in comet C/2009 P1 (Garradd) is (1.1±0.3)×10 29 s −1 and (0.75±0.05)×10 29 s −1 on 17 and 23 February 2012, respectively. CH3OH abundances relative to water are 2.7 ± 0.3% and 3.4 ± 0.6%, for comets 103P/Hartley 2 and C/2009 P1 (Garradd), respectively. Conclusions. The observed depletion of HCl suggests that HCl was not the main reservoir of chlorine in the regions of the solar nebula where these comets formed. HF was possibly the main fluorine compound in the gas phase of the outer solar nebula. However, this needs to be confirmed by future measurements.
Aspect-Oriented Support for Modular Parallel Computing

In this paper, we discuss the benefits of using aspect-oriented programming to develop parallel applications. We use aspects to separate parallelisation concerns into three categories: partition, concurrency and distribution. The achieved modularisation enables us to assemble a variety of platform specific parallel applications, by composing combinations of (reusable) aspect modules into domain-specific core functionality. The approach makes it feasible to develop parallel applications of a higher complexity than that achieved with traditional concurrent object oriented languages.
Making SQL Queries Correct on Incomplete Databases: A Feasibility Study

Multiple issues with SQL's handling of nulls have been well documented. Having efficiency as its key goal, evaluation of SQL queries disregards the standard notion of correctness on incomplete databases - certain answers - due to its high complexity. As a result, it may produce answers that are just plain wrong. It was recently shown that SQL evaluation can be modified, at least for first-order queries, to return only correct answers. But while these modifications came with good theoretical complexity bounds, they have not been tested in practice. The goals of this proof-of-concept paper are to understand whether wrong answers can be produced by SQL queries in real-world scenarios, and whether proposed techniques for avoiding them can be made practically feasible. We use the TPC-H benchmark, and show that for some typical queries involving negation, wrong answers are very common. On the other hand, existing solutions for fixing the problem do not work in practice at all. By analyzing the reasons for this, we come up with a new modified way of rewriting SQL queries that restores correctness. We conduct experiments which show the feasibility of our solution: the small price tag it imposes can be often tolerated to ensure correct results, and we do not miss correct answers that the usual SQL evaluation produces. The overall conclusion is that correct evaluation can be realistically achieved in the presence of nulls, at least for the SQL fragment that corresponds to first-order queries.
Overview of epidemiology, genetics, birth defects, and chromosome abnormalities associated with CDH

Congenital diaphragmatic hernia (CDH) is a common and well‐studied birth defect. The etiology of most cases remains unknown but increasing evidence points to genetic causation. The data supporting genetic etiologies which are detailed below include the association of CDH with recurring chromosome abnormalities, the existence of CDH‐multiplex families, and the co‐occurrence of CDH with additional congenital malformations. © 2007 Wiley‐Liss, Inc.
Costs of Control in Groups

This paper explores the role of social groups in explaining the reaction to control. We propose a simple model with a principal using control devices and a controlled agent, which incorporates the existence of social groups. Testing experimentally the conjectures derived from the model and related literature, we find that agents in social groups (i) perform more than other (no-group) agents; (ii) expect less control than no-group agents; (iii) decrease their performance substantially when actual control exceeds their expectation, while no-group agents do not react; (iv) do not reciprocate when facing less control than expected, while no-group agents do.
Differential Effects of Dual and Unihemispheric Motor Cortex Stimulation in Older Adults

Bihemispheric transcranial direct current stimulation (tDCS) is thought to upregulate excitability of the primary motor cortex (M1) using anodal stimulation while concurrently downregulating contralateral M1 using cathodal stimulation. This “dual” tDCS method enhances motor learning in healthy subjects and facilitates motor recovery after stroke. However, its impact on motor system activity and connectivity remains unknown. Therefore, we assessed neural correlates of dual and unihemispheric anodal tDCS effects in 20 healthy older subjects in a randomized, sham-controlled study using a cross-over design. Participants underwent tDCS and simultaneous functional magnetic resonance imaging during a choice reaction time task and at rest. Diffusion tensor imaging (DTI) allowed us to relate potential functional changes to structural parameters. The resting-state analysis demonstrated that, compared with sham, both dual and anodal tDCS decreased connectivity of right hippocampus and M1 (contralateral to the anode position) while increasing connectivity in the left prefrontal cortex. Notably, dual but not anodal tDCS enhanced connectivity of the left dorsal posterior cingulate cortex. Furthermore, dual tDCS yielded stronger activations in bilateral M1 compared with anodal tDCS when participants used either their left or right hand during the motor task. The corresponding tDCS-induced changes in laterality of activations were related to the microstructural status of transcallosal motor fibers. In conclusion, our results suggest that the impact of bihemispheric tDCS cannot be explained by mere add-on effects of anodal and concurrent cathodal stimulation, but rather by complex network modulations involving interhemispheric interactions and areas associated with motor control in the dorsal posterior cingulate cortex.
An Erythrocyte Vesicle Protein Exported by the Malaria Parasite Promotes Tubovesicular Lipid Import from the Host Cell Surface

Plasmodium falciparum is the protozoan parasite that causes the most virulent of human malarias. The blood stage parasites export several hundred proteins into their host erythrocyte that underlie modifications linked to major pathologies of the disease and parasite survival in the blood. Unfortunately, most are ‘hypothetical’ proteins of unknown function, and those that are essential for parasitization of the erythrocyte cannot be ‘knocked out’. Here, we combined bioinformatics and genome-wide expression analyses with a new series of transgenic and cellular assays to show for the first time in malaria parasites that microarray read out from a chemical perturbation can have predictive value. We thereby identified and characterized an exported P. falciparum protein resident in a new vesicular compartment induced by the parasite in the erythrocyte. This protein, named Erythrocyte Vesicle Protein 1 (EVP1), shows novel dynamics of distribution in the parasite and intraerythrocytic membranes. Evidence is presented that its expression results in a change in TVN-mediated lipid import at the host membrane and that it is required for intracellular parasite growth, but not invasion. This exported protein appears to be needed for the maintenance of an essential tubovesicular nutrient import pathway induced by the pathogen in the host cell. Our approach may be generalized to the analysis of hundreds of ‘hypothetical’ P. falciparum proteins to understand their role in parasite entry and/or growth in erythrocytes as well as phenotypic contributions to either antigen export or tubovesicular import. By functionally validating these unknowns, one may identify new targets in host–microbial interactions for prophylaxis against this major human pathogen.
Effects of methylphenidate on basic and higher-order oculomotor functions

Eye movements are sensitive indicators of pharmacological effects on sensorimotor and cognitive processing. Methylphenidate (MPH) is one of the most prescribed medications in psychiatry. It is increasingly used as a cognitive enhancer by healthy individuals. However, little is known of its effect on healthy cognition. Here we used oculomotor tests to evaluate the effects of MPH on basic oculomotor and executive functions. Twenty-nine males were given 20mg of MPH orally in a double-blind placebo-controlled crossover design. Participants performed visually-guided saccades, sinusoidal smooth pursuit, predictive saccades and antisaccades one hour post-capsule administration. Heart rate and blood pressure were assessed prior to capsule administration, and again before and after task performance. Visually-guided saccade latency decreased with MPH (p<0.004). Smooth pursuit gain increased on MPH (p<0.001) and number of saccades during pursuit decreased (p<0.001). Proportion of predictive saccades increased on MPH (p<0.004), specifically in conditions with predictable timing. Peak velocity of predictive saccades increased with MPH (p<0.01). Antisaccade errors and latency were unaffected. Physiological variables were also unaffected. The effects on visually-guided saccade latency and peak velocity are consistent with MPH effects on dopamine in basal ganglia. The improvements in predictive saccade conditions and smooth pursuit suggest effects on timing functions.