Miracle-dz/UniFAR-FTUs huggingface dataset:
Reticulocyte and erythrocyte hypochromia markers in detection of iron deficiency in adolescent female athletes

The aim of this study was to analyse the effectiveness of new haematology parameters related to reticulocytes and mature red blood cells to differentiate pre latent and latent iron deficiency. The study included 219 female athletes (aged 15-20 years) representing volleyball, handball, cycling, canoeing, cross-country skiing, swimming and judo. To assess iron status the concentration of ferritin, soluble transferrin receptor (sTfR), iron and total iron binding capacity (TIBC) were determined in serum. In addition to blood morphology, the mean cellular haemoglobin content in erythrocytes (CH) and reticulocytes (CHr), mean cellular haemoglobin concentration in reticulocytes (CHCMr), the percentage of erythrocytes (HYPOm) and reticulocytes (HYPOr) with decreased cellular haemoglobin concentration, the percentage of erythrocytes (LowCHm) and reticulocytes (LowCHr) with decreased cellular haemoglobin content, and percentage of erythrocytes with decreased volume (MICROm) were determined. Subjects with ferritin <30 ng/ml were classified as having stage I (pre-latent) iron deficiency (ID). The second stage (latent ID) was diagnosed when low ferritin was accompanied by elevated sTfR and/or elevated TIBC values. The frequency of ID (without anaemia symptoms) was high, amounting to 60% (stage I in 45%, stage II in 15% of subjects). In subjects with stage I ID significant changes in haematological variables concerned mainly reticulocytes: CHCMr (p<.001), CHr (p<.05), LowCHr (p<.05), HYPOr (p<.001) in comparison to normal iron stores. In athletes with latent ID, there were also significant changes (p<.001) in many indices of mature red blood cells, i.e. haemoglobin concentration (Hb), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), CH, %LowCHm, as well as %MICROm (p<.01) in relation to the group without iron deficiency. The main finding of this study was that the diminished or exhausted iron stores had already caused changes in reticulocytes, and intensified iron deficiency (stage II) increased changes in both reticulocytes’ and erythrocytes’ hypochromia indices, while microcythaemia symptoms appeared later. This suggests that the markers of hypochromia relating especially to reticulocytes are useful for diagnosis of early ID in athletes with absence of an acute phase reaction.
Loss of ACE2 Exacerbates Murine Renal Ischemia-Reperfusion Injury

Ischemia-reperfusion (I/R) is a model of acute kidney injury (AKI) that is characterized by vasoconstriction, oxidative stress, apoptosis and inflammation. Previous studies have shown that activation of the renin-angiotensin system (RAS) may contribute to these processes. Angiotensin converting enzyme 2 (ACE2) metabolizes angiotensin II (Ang II) to angiotensin-(1–7), and recent studies support a beneficial role for ACE2 in models of chronic kidney disease. However, the role of ACE2 in models of AKI has not been fully elucidated. In order to test the hypothesis that ACE2 plays a protective role in AKI we assessed I/R injury in wild-type (WT) mice and ACE2 knock-out (ACE2 KO) mice. ACE2 KO and WT mice exhibited similar histologic injury scores and measures of kidney function at 48 hours after reperfusion. Loss of ACE2 was associated with increased neutrophil, macrophage, and T cell infiltration in the kidney. mRNA levels for pro-inflammatory cytokines, interleukin-1β, interleukin-6 and tumour necrosis factor-α, as well as chemokines macrophage inflammatory protein 2 and monocyte chemoattractant protein-1, were increased in ACE2 KO mice compared to WT mice. Changes in inflammatory cell infiltrates and cytokine expression were also associated with greater apoptosis and oxidative stress in ACE2 KO mice compared to WT mice. These data demonstrate a protective effect of ACE2 in I/R AKI.
Dopaminergic modulation of emotional conflict in Parkinson's disease

Neuropsychiatric fluctuations in Parkinson's disease (PD) are frequent and disabling. One way to investigate them is to assess the ability to inhibit distractive emotional information by a modified emotional Stroop (ES) task. We compared non-depressed, non-demented PD patients with healthy controls. During an acute levodopa challenge, patients performed a modified ES task during functional MRI and a neuropsychological assessment including Visual Analog Mood (VAMS) and Apathy scales. Ten patients and 12 controls completed the study. The VAMS scores were significantly improved by the acute intake of levodopa (p = 0.02), as was the apathy score (p = 0.03). Negative ES task (i.e. fearful facial expressions with the words “happy” or “fear” written across them), induced a lengthening of the mean reaction time during the incongruent trials compared with the congruent trials in controls (relative difference = 2.7%, p < 0.001) and in ON patients (relative difference = 5.9%, p < 0.001), but not in OFF patients (relative difference = 1.7%, p = 0.28). Controls and ON patients displayed greater activation than OFF patients within the right pregenual anterior cingulate cortex (pACC), an area specifically involved in emotional conflict resolution (p < 0.001 and p < 0.008 respectively, k > 5 uncorrected). No difference in the activation of the pACC was found between controls and ON patients, suggesting a normalization of the activation following levodopa administration. These results suggest that emotional conflict processes could be dopamine-dependent. Pregenual ACC hypoactivation could be directly due to the degeneration of dopaminergic mesocorticolimbic pathway. Our results propose that neuropsychiatric fluctuations in PD patients could be partially explained by pACC hypoactivation and that adjustments of dopaminergic medication might be helpful for their treatment.
Simple functional performance tests and mortality in COPD

Exercise tests are important to characterise chronic obstructive pulmonary disease patients and predict their prognosis, but are often not available outside of rehabilitation or research settings. Our aim was to assess the predictive performance of the sit-to-stand and handgrip strength tests. The prospective cohort study in Dutch and Swiss primary care settings included a broad spectrum of patients (n=409) with Global Initiative for Chronic Obstructive Lung Disease stages II to IV. To assess the association of the tests with outcomes, we used Cox proportional hazards (mortality), negative binomial (centrally adjudicated exacerbations) and mixed linear regression models (longitudinal health-related quality of life) while adjusting for age, sex and severity of disease. The sit-to-stand test was strongly (adjusted hazard ratio per five more repetitions of 0.58, 95% CI 0.40–0.85; p=0.004) and the handgrip strength test moderately strongly (0.84, 95% CI 0.72–1.00; p=0.04) associated with mortality. Both tests were also significantly associated with health-related quality of life but not with exacerbations. The sit-to-stand test alone was a stronger predictor of 2-year mortality (area under curve 0.78) than body mass index (0.52), forced expiratory volume in 1 s (0.61), dyspnoea (0.63) and handgrip strength (0.62). The sit-to-stand test may close an important gap in the evaluation of exercise capacity and prognosis of chronic obstructive pulmonary disease patients across practice settings. The 1-min sit-to-stand test predicts mortality in COPD patients and can easily be implemented across practice settings http://ow.ly/mxrPx
Learning Script Knowledge with Web Experiments

We describe a novel approach to unsupervised learning of the events that make up a script, along with constraints on their temporal ordering. We collect natural-language descriptions of script-specific event sequences from volunteers over the Internet. Then we compute a graph representation of the script's temporal structure using a multiple sequence alignment algorithm. The evaluation of our system shows that we outperform two informed baselines.
Nutritional well-being of young children in Duncan Village, East London, South Africa: accessibility of primary health care clinics

Abstract Objective The aim was to contribute to the nutritional well-being of young children living in Duncan Village by investigating factors that influence clinic attendance of mothers and to formulate recommendations for optimisation of accessibility of primary health care (PHC) clinics in the area. Design PHC clinic accessibility was evaluated by assessing the experiences of mothers who attended clinics in the area as well as the experiences of health care workers (HCWs) in these clinics of service delivery and its recipients (mothers/children), using the focus group technique. The ATLAS/ti program was used to analyse the data in the following steps: preparation and importing of the data, getting to know and coding the data, retrieval and examination of codes and quotations, creation of families and creation of networks. Setting Duncan Village, a low socio-economic urban settlement in East London, South Africa. Subjects Focus group discussions (four to seven participants per group) were conducted with four groups of mothers who do not attend PHC clinics, six with mothers who do attend the clinics (including pregnant women) and four groups of HCWs. Results Four networks that provide a summary of all the major trends in the data were created. The results clearly indicate that mothers in Duncan Village perceive and/or experience serious problems that make it difficult for them to attend clinic and even prevent them from doing so. These problems include both the way they are treated at the clinics (especially the problem of verbal abuse) as well as the actual services delivered (no medicines, no help, disorganised, long waiting periods, being turned away). The main problem experienced by the HCWs with service delivery seems to be a heavy workload, as well as the fact that many mothers do not come for follow-up visits. Conclusion Efforts to increase the accessibility of PHC clinics in Duncan Village should focus on improving the relationship between mothers and HCWs and the heavy workload experienced by these workers.
Contributions to conceptual growth: The elaboration of Ellis's model for information‐seeking behavior

Using Ellis's seminal model of information seeking as an example, this study demonstrates how the elaborations made to the original framework since the late 1980s have contributed to conceptual growth in information‐seeking studies. To this end, nine key studies elaborating Ellis's model were scrutinized by conceptual analysis. The findings indicate that the elaborations are based on two main approaches: adding novel, context‐specific components in the model and redefining and restructuring the components. The elaborations have contributed to conceptual growth in three major ways. First, integrating formerly separate parts of knowledge; second, generalizing and explaining lower abstraction‐level knowledge through higher‐level constructs; and third, expanding knowledge by identifying new characteristics of the object of study, that is, information‐seeking behavior. Further elaboration of Ellis's model toward a theory would require more focused attempts to test hypotheses in work‐related environments in particular.
Accelerating motor adaptation by virtual reality based modulation of error memories

When exposed to visual perturbations, the motor system rapidly learns to reduce errors through adaptation of future motor commands. However, in cerebellar and stroke patients with proprioceptive impairments, motor adaptation rates are significantly slower. A recent study suggests that adaptation rates may be modulated by the stability of perturbations and the history of errors. We hypothesize that reducing the visual magnitude of directional error in a reaching task should increase the speed of motor adaptation to a perturbation. We developed a method for the modulation of error magnitudes in virtual reality (VR), and we conducted two experiments exploring its effects on adaptation. 34 healthy subjects used a chair-mounted arm support to perform reaching movements towards a target while learning to compensate for visuomotor rotations. We observed that diminishing the visually perceived variability of visual directional error through VR accelerates adaptation. This effect showed persistence into trials when virtual error reduction was no longer present confirming the modulatory role of error memory. These findings support the hypothesis that the brain may keep a history of recent errors and differentially adjusts learning rates relative to the frequency of occurrence of errors. We predict that exposure to a distribution of visual motor errors with low variability and centered around task-relevant error values accelerates motor adaptation in patients with cerebellar degeneration.
Role of Vacancies in Zigzag Graphene Nanoribbons: An Ab Initio Study

We have studied the effects of vacancies on the structural, electronic and magnetic properties of zigzag-edged graphene nanoribbons (ZGNRs). Our calculations were carried out using an abinitio density functional pseudopotential computational method combined with the generalized gradient approximation for the exchange-correlation functional. The equilibrium geometries, electronic charge spin density distributions, electronic band structures, and magnetic moments were examined in the presence of single vacancy and double vacancies. Structural optimization showed that vacancies induce substantial structural changes in ZGNRs. We found that introducing vacancies into ZGNR changes the spatial distribution of neighbor atoms, particularly those located around the vacancies. Our calculations showed that the vacancies have significant effect on the magnetization of ZGNR. The calculations showed that the changes in the structural geometry, the electronic structure and the magnetization of ZGNR depend on the location of the vacancies with respect to the ribbon edges. These results suggest that vacancy defects can be used to modify the electronic and the magnetic properties of ZGNR.
Complex quantum dot arrays formed by combination of self-organized anisotropic strain engineering and step engineering on shallow patterned substrates

One-dimensional (In,Ga)As quantum dot (QD) arrays are created on planar singular, vicinal, and shallow mesa-patterned GaAs (100) substrates by self-organized anisotropic strain engineering of an (In,Ga)As∕GaAs quantum wire (QWR) superlattice template in molecular beam epitaxy. On planar singular substrates, highly uniform single QD arrays along [0−11] are formed. On shallow [0−11] and [011] stripe-patterned substrates, the generated type-A and -B steps distinctly affect the surface migration processes which are crucial for QWR template development, i.e., strain-gradient-driven In adatom migration along [011] and surface-reconstruction-induced Ga∕In adatom migration along [0−11]. In the presence of both type-A and -B steps on vicinal substrates misoriented towards [101], the direction of adatom migration is altered to rotate the QD arrays. This establishes the relationship between self-organized anisotropic strain and step engineering, which is exploited on shallow zigzag-patterned substrates for the reali.
Abnormal synchrony of resting state networks in premanifest and symptomatic Huntington disease: the IMAGE-HD study.

BACKGROUND Functional neural impairments have been documented in people with symptomatic Huntington disease (symp-HD) and in premanifest gene carriers (pre-HD). This study aimed to characterize synchrony in resting state cerebral networks in both pre-HD and symp-HD populations and to determine its association with disease burden and neurocognitive functions. METHODS We acquired functional magnetic resonance imaging (fMRI) data from pre-HD, symp-HD and healthy control participants. The fMRI data were analyzed using multisubject independent component analysis and dual regression. We compared networks of interest among the groups using a nonparametric permutation method and correcting for multiple comparisons. RESULTS Our study included 25 people in the pre-HD, 23 in the symp-HD and 18 in the healthy control groups. Compared with the control group, the pre-HD group showed decreased synchrony in the sensorimotor and dorsal attention networks; decreased level of synchrony in the sensorimotor network was associated with poorer motor performance. Compared with the control group, the symp-HD group showed widespread reduction in synchrony in the dorsal attention network, which was associated with poorer cognitive performance. The posterior putamen and superior parietal cortex were functionally disconnected from the frontal executive network in the symp-HD compared with control and pre-HD groups. Furthermore, the left frontoparietal network showed areas of increased synchrony in the symp-HD compared with the pre-HD group. LIMITATIONS We could not directly correct for influence of autonomic changes (e.g., heart rate) and respiration on resting state synchronization. CONCLUSION Our findings suggest that aberrant synchrony in the sensorimotor and dorsal attention networks may serve as an early signature of neural change in pre-HD individuals. The altered synchrony in dorsal attention, frontoparietal and corticostriatal networks may contribute to the development of clinical symptoms in people with Huntington disease.
PASSIVE WI-FI: Bringing Low Power to Wi-Fi Transmissions

Wi-Fi has traditionally been considered a power-consuming communication system and has not been widely adopted in the sensor network and Internet of Things (IoT) space. We introduce Passive Wi-Fi that demonstrates that one can generate 802.11b transmissions using backscatter communication, while consuming 3-4 orders of magnitude lower power than existing Wi-Fi chipsets. Passive Wi-Fi transmissions can be decoded on any Wi-Fi device including routers, mobile phones and tablets. Our experimental evaluation shows that passive Wi-Fi transmissions can be decoded on off-the-shelf smartphones and Wi-Fi chipsets over distances of up to 100 feet. We also design a passive Wi-Fi IC that shows that 1 and 11 Mbps transmissions consume 14.5 and 59.2 ? W respectively. This translates to 10000x lower power than existing Wi-Fi chipsets and 1000x lower power than Bluetooth LE and ZigBee.
Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein

The transcription factor Gli3 is expressed throughout developing telencephalon. Previous studies have focused on Gli3's role in dorsal telencephalon, which is greatly reduced in size in Gli3Xt/Xt mutants. We examined the effects of loss of Gli3 on early development of ventral telencephalon. Ventral telencephalon was defined in both wildtypes and Gli3Xt/Xt mutants on the basis of its expression of Olig2, Nkx2.1, Mash1, and Foxg1 and its lack of expression of Pax6. We found that at embryonic day (E)10.5 the volume of the ventral telencephalon is about 50% greater in Gli3Xt/Xt mutants than in wildtypes. By E12.5, however, the volume of the ventral telencephalon is about 20% lower in Gli3Xt/Xt mutants than in wildtypes. We observed a significant increase in the number of both apoptotic cells and newly differentiated neurons in the E10.5 Gli3Xt/Xt ventral telencephalon, suggesting that increased cell death and withdrawal of cells from the cell cycle might account for the failure of the Gli3Xt/Xt ventral telencephalon to grow normally by E12.5. We found no changes in the lengths of the cell cycles of proliferating ventral telencephalic cells at E10.5. We used marker analysis and optical projection tomography to assess the Gli3Xt/Xt forebrain in three dimensions and found that the Gli3Xt/Xt diencephalon is shifted relatively rostrally. We conclude that in the absence of Gli3 an abnormally large portion of the newly formed telencephalon is specified to a ventral fate but this then suffers impaired growth, due to defects of cell differentiation and death, contributing to severe distortion of the forebrain. J. Comp. Neurol. 512:613–627, 2009. © 2008 Wiley‐Liss, Inc.
Attenuation by genistein of sodium‐chloride‐enhanced gastric carcinogenesis induced by N‐methyl‐N′‐nitro‐N‐nitrosoguanidine in Wistar rats

The effects of prolonged administration of genistein, a tyrosine‐kinase inhibitor, on sodium‐chloride‐enhanced induction of gastric carcinogenesis induced by N‐methyl‐N′‐nitro‐N‐nitrosoguanidine, and the labeling and apoptotic indices and vessel counts in the gastric mucosa and gastric cancers, were investigated in Wistar rats. After 25 weeks of the carcinogen treatment, rats were fed chow pellets containing 10% sodium chloride and were given s.c. injections of genistein at dosages of 15 mg/kg or 30 mg/kg body weight every other day. In week 52, the incidence of gastric cancers was significantly greater in rats fed sodium chloride than in untreated control rats. Prolonged administration of genistein at a dosage of 30 mg/kg, but not 15 mg/kg, body weight significantly reduced the incidence of gastric cancers, which was increased by oral treatment with sodium chloride. Genistein at the higher dose significantly decreased the labeling index and vessel counts of the antral mucosa and the gastric cancers (which were increased by treatment with sodium chloride) and significantly increased the apoptotic index of the antral mucosa and the cancers (which was lowered by the treatment with sodium chloride). These findings suggest that genistein attenuates gastric carcinogenesis promoted by sodium chloride, by inducing increased apoptosis and lower cell proliferation and angiogenesis of antral mucosa and gastric cancers. Int. J. Cancer 80:396–399, 1999. © 1999 Wiley‐Liss, Inc.
Solution Representations and Local Search for the bi-objective Inventory Routing Problem

The solution of the biobjective IRP is rather challenging, even for metaheuristics. We are still lacking a profound understanding of appropriate solution representations and effective neighborhood structures. Clearly, both the delivery volumes and the routing aspects of the alternatives need to be reflected in an encoding, and must be modified when searching by means of local search. Our work contributes to the better understanding of such solution representations. On the basis of an experimental investigation, the advantages and drawbacks of two encodings are studied and compared.
Playing games as a way to improve automatic image annotation

Image annotation is hard to do in an automatic way. In this paper, we propose a framework for image annotation that combines the benefits of three paradigms: automatic annotation, human intervention and entertainment activities. We also describe our proposal inside this framework, the ASAA (application for semi-automatic annotation) interface, a new computer game for image tagging. The application has a 3D game interface, and is supported by a game engine that uses a system for automatic image classification and gestural input to play the game. We present results of the performance of semantic models obtained with a training set enlarged by images annotated during the game activity as well as usability tests of the application.