Miracle-dz/UniFAR-FTUs huggingface dataset:
Aspect-aware Point-of-Interest Recommendation with Geo-Social Influence

The large volume of data available in location-based social networks (LBSNs) enables Point-of-Interest (POI) recommendation services. On another hand, the heterogeneous information (e.g., user check-in records, geographical features of POIs, social network and user reviews) imposes great challenges on effective POI recommendation. In this paper, we focus on leveraging such rich information in an integrated manner to improve POI recommendation performance. We exploit not only the geographical and social information, but also aspects extracted from user reviews to better model users' preferences. More specifically, to fully utilize various types of information, we construct a novel heterogeneous graph, Aspect-aware Geo-Social influence Graph (AGSG), by fusing various relations among the three types of nodes, i.e., users, POIs and aspects. The personalized POI recommendation task is then transformed as a graph node ranking problem in AGSG. We design a graph-based recommendation algorithm based on both personalized PageRank (PPR) and meta paths, to fully exploit the heterogeneous graph structure as well as to capture the semantic relations among the various nodes. Experiments on three real-world datasets show that our proposed approach outperforms the state-of-art methods.
Influenza A and B Virus Intertypic Reassortment through Compatible Viral Packaging Signals

ABSTRACT Influenza A and B viruses cocirculate in humans and together cause disease and seasonal epidemics. These two types of influenza viruses are evolutionarily divergent, and exchange of genetic segments inside coinfected cells occurs frequently within types but never between influenza A and B viruses. Possible mechanisms inhibiting the intertypic reassortment of genetic segments could be due to incompatible protein functions of segment homologs, a lack of processing of heterotypic segments by influenza virus RNA-dependent RNA polymerase, an inhibitory effect of viral proteins on heterotypic virus function, or an inability to specifically incorporate heterotypic segments into budding virions. Here, we demonstrate that the full-length hemagglutinin (HA) of prototype influenza B viruses can complement the function of multiple influenza A viruses. We show that viral noncoding regions were sufficient to drive gene expression for either type A or B influenza virus with its cognate or heterotypic polymerase. The native influenza B virus HA segment could not be incorporated into influenza A virus virions. However, by adding the influenza A virus packaging signals to full-length influenza B virus glycoproteins, we rescued influenza A viruses that possessed HA, NA, or both HA and NA of influenza B virus. Furthermore, we show that, similar to single-cycle infectious influenza A virus, influenza B virus cannot incorporate heterotypic transgenes due to packaging signal incompatibilities. Altogether, these results demonstrate that the lack of influenza A and B virus reassortants can be attributed at least in part to incompatibilities in the virus-specific packaging signals required for effective segment incorporation into nascent virions. IMPORTANCE Reassortment of influenza A or B viruses provides an evolutionary strategy leading to unique genotypes, which can spawn influenza A viruses with pandemic potential. However, the mechanism preventing intertypic reassortment or gene exchange between influenza A and B viruses is not well understood. Nucleotides comprising the coding termini of each influenza A virus gene segment are required for specific segment incorporation during budding. Whether influenza B virus shares a similar selective packaging strategy or if packaging signals prevent intertypic reassortment remains unknown. Here, we provide evidence suggesting a similar mechanism of influenza B virus genome packaging. Furthermore, by appending influenza A virus packaging signals onto influenza B virus segments, we rescued recombinant influenza A/B viruses that could reassort in vitro with another influenza A virus. These findings suggest that the divergent evolution of packaging signals aids with the speciation of influenza A and B viruses and is in part responsible for the lack of intertypic viral reassortment.
The â€œMigrant in the Marketâ€: Migration and Care Work Across Six Liberal Welfare Regimes

This article disaggregates high and low status care work, based on the degree of â€œsocial closureâ€ in a given caring occupation, across six liberal welfare regimes: Australia, Canada, Ireland, Israel, the United Kingdom, and the United States. Bolstering the argument that there is a â€œmigrant in the marketâ€ model of employment unique to liberal welfare regimes, the data demonstrate that foreign-born individuals are more likely to perform low status, precarious care work within each country than the native-born and that migrant workers experience an overall wage penalty in the labour force, as well as there being an additional penalty for those who perform service work in the realms of education and health.
Nosocomial Methicilin-Resistant Staphylococcus aureus Endocarditis with Splenic Abscess in a Pregnant Woman

A 36-year-old, 7-week-gravida patient with catheter-related nosocomial infective endocarditis due to methicillin-resistant Staphylococcus aureus (MRSA) is presented in this paper. The patient was admitted to our hospital because of carbon monoxide intoxication. After 14 days, MRSA catheter-related bacteremia developed. The central venous catheter was immediately removed, and teicoplanin therapy was started. Because of persistent fever, leukocytosis, and high C-reactive protein values, endocarditis was suspected. A transesophageal echocardiogram revealed 19-mm vegetation on her mitral valve, confirming the diagnosis of endocarditis. Gentamicin and rifampicin were added to the therapy regimen, and the dose of teicoplanin was increased to 12 mg/kg-day. After 8 days, a splenic abscess was detected by ultrasonography. Vegetation excision, mitral valve replacement by open-heart surgery and splenectomy were performed in the same operation. Antibiotherapy was continued for 6 weeks after surgery, and the patient's condition improved. The development of endocarditis could be prevented by proper clinical practices.
CORRUPTION, INSTITUTIONS AND ECONOMIC GROWTH IN SUB-

Corruption is a important trouble and social ethics has a remarkable impact on all countries. It is a fact which exists in many countries and a trouble for the economy. Economists and various researchers in recent years have shown an increasing interest in studying the phenomenon of corruption and its impact on economic growth. This study aims to investigate the causal relationship among corruption, economic freedom and economic growth in some selected Sub-Saharan African (SSA) countries with a view to making policy implications using the Granger causality test within a multivariate cointegration and error-correction framework for the 1996-2014 period. The findings indicate that economic freedom Granger-causes economic growth in the short term, while economic freedom and economic growth Granger-cause corruption in the long term. Furthermore, we employed the forecast error variance decomposition and impulse response function analyses to investigate the dynamic interaction between the variables. The results demonstrate positive unidirectional Granger causality from economic freedom to economic growth in the short term and positive unidirectional Granger causality from economic freedom and economic growth to corruption in the long term in SSA countries.
Stone-Mode Ultrasound for Determining Renal Stone Size.

PURPOSE The purpose of this study was to measure the accuracy of stone-specific algorithms (S-mode) and the posterior acoustic shadow for determining kidney stone size with ultrasound (US) in vivo. MATERIALS AND METHODS Thirty-four subjects with 115 renal stones were prospectively recruited and scanned with S-mode on a research US system. S-mode is gray-scale US adjusted to enhanced stone contrast and resolution by minimizing compression and averaging, and increasing line density and frequency. Stone and shadow width were compared with a recent CT scan and, in 5 subjects with 18 stones, S-mode was compared with a clinical US system. RESULTS Overall, 84% of stones identified on CT were detected on S-mode and 66% of these shadowed. Seventy-three percent of the stone measurements and 85% of the shadow measurements were within 2 mm of the size on CT. A posterior acoustic shadow was present in 89% of stones over 5 mm versus 53% of stones under 5 mm. S-mode visualized 78% of stones, versus 61% for the clinical system. S-mode stone and shadow measurements differed from CT by 1.6 ± 1.0 mm and 0.8 ± 0.6 mm, respectively, compared with 2.0 ± 1.5 mm and 1.6 ± 1.0 mm for the clinical system. CONCLUSIONS S-mode offers improved visualization and sizing of renal stones. With S-mode, sizing of the stone itself and the posterior acoustic shadow were similarly accurate. Stones that do not shadow are most likely <5 mm and small enough to pass spontaneously.
Factors affecting citizens' adoption of E-Government services in Libya

In the 21st century, many countries are providing services to their citizens using the Internet. In countries such as Libya, where the population is spread over a large geographical area, the need to deploy services via the Internet is very evident. This research employs the Technology Acceptance Model integrated with the Diffusion of Innovations Theory to identify and assess factors that could influence Libyan citizens to adopt e-government services in Libya. The main benefit of this research is that it is the first study to tackle this issue in Libya. A quantitative research methodology via a paper-based self-administered questionnaire was used to collect data. All the variables considered in this research were statistically significant except in the case of Trust of the Internet on Perceived Ease Of Use. Perceived Ease Of Use and Perceived Usefulness are significant antecedents of Intention To Use. Computer Self-Efficacy and Facilitating Conditions have a significant relationship with Perceived Ease Of Use. Moreover, Subjective Norms, Image, Beliefs, and Perceived Ease Of Use were empirically observed to influence Perceived Usefulness. Second, the moderating role of citizen characteristics which include gender, age, education, and Internet experience was supported by the data. Analysis of the empirical data indicates the following actions from Libyan government will have implications for successful adoption of e-government services in Libya: launched its services in ease to use manner, provide services that are centred around the need for the users, identify to its citezens the advantages of using e-government services as an alternative to other means of interacting with its government agencies, launch efforts to increase Information Technology literacy, provide people with required resources to use e-government, and give special concerns to aspects that can have relation to prevalent beliefs in the Libyan society.
Transcriptional potentiation of the vitellogenin B1 promoter by a combination of both nucleosome assembly and transcription factors: an in vitro dissection

The Xenopus laevis vitellogenin B1 promoter was assembled into nucleosomes in an oocyte extract. Subsequent RNA polymerase II-dependent transcription from these DNA templates fully reconstituted in chromatin in a HeLa nuclear extract was increased 50-fold compared with naked DNA. Remarkably, under specific conditions, production of a high level of transcripts occurred at very low DNA (1 ng/microliter) and HeLa nuclear protein (1.6 micrograms/microliters) concentrations. When partially reconstituted templates were used, transcription efficiency was intermediate between that of fully reconstituted and naked DNA. These results implicate chromatin in the process of the transcriptional activation observed. Depletion from the oocyte assembly extract of an NF-I-like factor which binds in the promoter region upstream of the TATA box (-114 to -101) or deletion from the promoter of the region interacting with this factor reduced the transcriptional efficiency of the assembled templates by a factor of 5, but transcription of these templates was still 10 times higher than that of naked DNA. Together, these results indicate that the NF-I-like factor participates in the very efficient transcriptional potentiation of the vitellogenin B1 promoter which occurs during nucleosome assembly.
Job quality in Britain

The aim of Praxis is to stimulate discussion and debate on employment and skills policy issues. This edition raises a number of critical issues that have significant implications for employment and skills policy development. In the last decade job quality has been a prominent issue in policy circles. The vision of ‘more and better jobs’ has been advanced by the British government, and separately by both the Organisation for Economic Cooperation and Development and the European Commission. Business leaders, at the same time, have called for more skilled workers, while trade unions have been drawing attention to the increasingly demanding and stressful nature of modern workplaces and the need to improve the quality of work life (European Commission, 2008).
Temporomandibular disorders in children and adolescents: reliability of a questionnaire, clinical examination, and diagnosis.

Recently developed Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) have been shown to be reliable for diagnosing and assessing TMD in U.S. and Swedish adult populations; however, few studies have focused on clinical examination methods and diagnostic criteria for use with children and adolescents. The present study used a sample of 50 Swedish children and adolescents, aged 12 to 18 years, to evaluate usefulness and reliability of existing and specially developed measures and methods for assessing and diagnosing TMD in youth. Subjects underwent repeated clinical exams by two calibrated examiners to assess signs and symptoms per the RDC/TMD, and they responded to a specially developed self-administered questionnaire that addressed location and frequency of TMD-related pain and symptoms, jaw function, effect of pain on daily activities, and use of pain medications. Interexaminer and intraexaminer reliability was assessed for clinical examination, questionnaire items, and diagnosis. Reliability values ranged from acceptable to excellent for the RDC/TMD clinical exam and questionnaire, and from good to excellent reliability for measuring virtually all modified clinical parameters of TMD assessed in these young patients.
Application of Vine Copula in Multi-market Dependence Research

This paper forecasted VaR for multi-market assets (serval kinds of energy assets, stock, gold and US Dollars) by using Vine-copula model. The findings of the research showed that the Vine Copula model displayed more flexibilities and efficiencies than the traditional Bivariate Copula model in characterizing dependencies between multi assets, and R-Vine Copula model proved the best accuracy compared with the C-Vine and D-Vine Copula model. Introduction Energy plays an important role in the national economy. With the oil crisis and market turmoil, the price of ri hment of a risk management model to capture the characteristics is very important for risk managers. This study of interdependence between different markets is the focus for recent domestic and foreign scholars. Krehbiel and Adkins (2005) applied McNeil and Frey’s two-stage method to construct model of futures market risk, and pointed out that the conditional extreme value theory has obvious advantages in the assessment of the energy market’s price risk. But they couldn’t make comparison between conditional extreme model and fat-tailed model (such as the distribution of student t) and make backward inspection for empirical results. Marimoutou, Raggad,and Trabelsi (2009) applied the same method to model VaR of oil futures market and conducted a backward test. It is pointed out that conditional extreme frame should be superior to conventional risk management methods. Jia Liu (2011) analyzed and discussed the conventional risk management, value ant risk, the expected loss and replaceable relevant risk management methods in the research of risk management on energy market. McNeil and Frey’s two-stage method was used to analyze investment portfolio of energy futures and stock (S & P) and dollars, based on historical data. The dependence of multi-market assets (including energy assets, stock, dollar and gold) will be studied in this research, in order to provide theoretical suggestions for policy makers and financial investors. Research methods Edge distribution model. The financial assets return rate data would generally show asymmetric volatility aggregation and leverage effect and features such as peak, fat tail and skewness. The application of AR (1)-GJR-GARCH (1, 1)-Skew-t model could effectively describe such features of return rate data of assets in stock types, 1 0 1 i it it i it r c c r ε − = + + , (1.1) it it it z ε σ = (1.2) 2 2 2 2 1 1 1 1 it i i it i it i it it I σ μ α ε β σ γ ε − − − − = + + + (1.3) ~ . ( , ) it z i i d ST η λ (1.4) 2nd International Conference on Materials Science, Machinery and Energy Engineering (MSMEE 2017) Copyright © 2017, the Authors. Published by Atlantis Press. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/). Advances in Engineering Research, volume 123
Sex drives intracellular conflict in yeast

Theory predicts that sex can drive the evolution of conflict within the cell. During asexual reproduction, genetic material within the cell is inherited as a single unit, selecting for cooperation both within the genome as well as between the extra‐genomic elements within the cell (e.g. plasmids and endosymbionts). Under sexual reproduction, this unity is broken down as parental genomes are distributed between meiotic progeny. Genetic elements able to transmit to more than 50% of meiotic progeny have a transmission advantage over the rest of the genome and are able to spread, even where they reduce the fitness of the individual as a whole. Sexual reproduction is therefore expected to drive the evolution of selfish genetic elements (SGEs). Here, we directly test this hypothesis by studying the evolution of two independent SGEs, the 2‐μm plasmid and selfish mitochondria, in populations of Saccharomyces cerevisiae. Following 22 rounds of sexual reproduction, 2‐μm copy number increased by approximately 13.2 (± 5.6) copies per cell, whereas in asexual populations copy number decreased by approximately 5.1 (± 1.5) copies per cell. Given that the burden imposed by this parasite increases with copy number, these results support the idea that sex drives the evolution of increased SGE virulence. Moreover, we found that mitochondria that are respiratory‐deficient rapidly invaded sexual but not asexual populations, demonstrating that frequent outcrossed sex can drive the de novo evolution of genetic parasites. Our study highlights the genomic perils of sex and suggests that SGEs may play a key role in driving major evolutionary transitions, such as uniparental inheritance.
Comments on “Comparative Study With New Accuracy Metrics for Target Volume Contouring in PET Image Guided Radiation Therapy”

Phantom measurements with glass inserts in a hot background are still used frequently for calibration and performance assessment of volume delineation algorithms in positron emission tomography (PET). Taking as an example the recent paper “Comparative study with new accuracy metrics for target volume contouring in PET image guided radiation therapy” (Shepherd, 2012), we demonstrate that this is not a valid approach due to the discontinuity introduced in the background by the cold walls of the glass inserts. We, moreover, emphasize that in order to define a sensible ground truth for performance assessment of contouring algorithms in patient data it is necessary to average over a sizable number of experienced observers and lesions in order to compensate for the substantial inter-observer variability.
Capsular Polysaccharide Surrounds Smooth and Rugose Types of Salmonella enterica serovar Typhimurium DT104

ABSTRACT The biofilms and rugose colony morphology of Salmonella enterica serovar Typhimurium strains are usually associated with at least two different exopolymeric substances (EPS), curli and cellulose. In this study, another EPS, a capsular polysaccharide (CP) synthesized constitutively in S. enterica serovar Typhimurium strain DT104 at 25 and 37°C, has been recognized as a biofilm matrix component as well. Fluorophore-assisted carbohydrate electrophoresis (FACE) analysis indicated that the CP is comprised principally of glucose and mannose, with galactose as a minor constituent. The composition differs from that of known colanic acid-containing CP that is isolated from cells of Escherichia coli and other enteric bacteria grown at 37°C. The reactivity of carbohydrate-specific lectins conjugated to fluorescein isothiocyanate or gold particles with cellular carbohydrates demonstrated the cell surface localization of CP. Further, lectin binding also correlated with the FACE analysis of CP. Immunoelectron microscopy, using specific antibodies against CP, confirmed that CP surrounds the cells. Confocal microscopy of antibody-labeled cells showed greater biofilm formation at 25°C than at 37°C. Since the CP was shown to be produced at both 37°C and 25°C, it does not appear to be significantly involved in attachment during the early formation of the biofilm matrix. Although the attachment of S. enterica serovar Typhimurium DT104 does not appear to be mediated by its CP, the capsule does contribute to the biofilm matrix and may have a role in other features of this organism, such as virulence, as has been shown previously for the capsules of other gram-negative and gram-positive bacteria.
Recurrent laryngeal nerve regeneration using an oriented collagen scaffold containing Schwann cells

Regeneration of the recurrent laryngeal nerve (RLN), which innervates the intrinsic laryngeal muscles such that they can perform complex functions, is particularly difficult to achieve. Synkinesis after RLN neogenesis leads to uncoordinated movement of laryngeal muscles. Recently, some basic research studies have used cultured Schwann cells (SCs) to repair peripheral nerve injuries. This study aimed to regenerate the RLN using an oriented collagen scaffold containing cultured SCs.
Changing mental models and developing global mind-sets of business students through international study modules

The fast-changing interdependent global context and the accompanying need to teach capabilities required in the global marketplace led to the implementation of international global modules for business management students. The study explored students' perceptions about their learning experiences on international modules to BRIC (Brazil, Russia, India, China) countries abroad. The findings suggest that a module abroad encouraged a broader vision outside of their own mental representations and contributed to the development of students' mental models and global mind-sets. The module exposed them to foreign ways of thinking and behaving in diverse contexts and in so-doing disturbed current thinking. The global educational experience enhanced experiential learning, stimulated reflection, and contributed to the development and transfer of deep knowledge. This article provides insight into the experienced value of international global modules, and it proposes a reflection framework on improving the learning outcomes of such modules abroad.