Miracle-dz/UniFAR-FTUs huggingface dataset:
Design of double-walled carbon nanotubes for biomedical applications

Double-walled carbon nanotubes (DWNTs) prepared by catalytic chemical vapour deposition were functionalized in such a way that they were optimally designed as a nano-vector for the delivery of small interfering RNA (siRNA), which is of great interest for biomedical research and drug development. DWNTs were initially oxidized and coated with a polypeptide (Poly(Lys:Phe)), which was then conjugated to thiol-modified siRNA using a heterobifunctional cross-linker. The obtained oxDWNT–siRNA was characterized by Raman spectroscopy inside and outside a biological environment (mammalian cells). Uptake of the custom-designed nanotubes was not associated with detectable biochemical perturbations in cultured cells, but transfection of cells with DWNTs loaded with siRNA targeting the green fluorescent protein (GFP) gene, serving as a model system, as well as with therapeutic siRNA targeting the survivin gene, led to a significant gene silencing effect, and in the latter case a resulting apoptotic effect in cancer cells.
Familial Multiple Coagulation Factor Deficiencies

significantly reduced levels of Factors IX (30-36%) and XI (1-3%). Their brother (II:1) had lesser and variable reductions of Factors IX (45-100%) and XI (35-100%). Both parents and other studied rela tives (not shown) had normal PTTs and Factor IX and XI levels. The pattern of FMFD VI in this family is consistent with autosomal inheritance. Based on the greater magnitude of deficiencies in the two sisters than in their brother, II:2 and II:3 presumably are homozygous and II:1 is heterozygous for FMFD VI. The failure to detect deficiencies in the parents (obligate heterozygotes) may be due to vari ability in the heterozygous state or partial penetrance in heterozygotes.
Single image dehazing with varying atmospheric light intensity

Images taken in bad weather conditions like haze and fog suffer from loss of contrast and color shift. The object radiance is attenuated in the atmosphere and the atmospheric light is added to the scene radiance creating a veil like semi-transparent layer called airlight. The methods proposed till now assumes that the atmospheric light is constant throughout the image domain, which may not be true always. Here we propose a method that works under the relaxed assumption that the color of atmospheric light is constant but its intensity may vary in the image. We use the color line model to estimate the contribution of airlight in each patch and interpolate at places where the estimate is not reliable. We apply reverse operation to recover the haze free image.
Diversity-Multiplexing Tradeoff via Asymptotic Analysis of Large MIMO Systems

Diversity-multiplexing tradeoff (DMT) presents a compact framework to compare various MIMO systems and channels in terms of the two main advantages they provide (i.e. high data rate and/or low error rate). This tradeoff was characterized asymptotically (SNR-> infinity) for i.i. d. Rayleigh fading channel by Zheng and Tse [1]. The asymptotic DMT overestimates the finite-SNR one [2]. In this paper, using the recent results on the asymptotic (in the number of antennas) outage capacity distribution, we derive and analyze the finite- SNR DMT for a broad class of channels (not necessarily Rayleigh fading). Based on this, we give the convergence conditions for the asymptotic DMT to be approached by the finite-SNR one. The multiplexing gain definition is shown to affect critically the convergence point: when the multiplexing gain is defined via the mean (ergodic) capacity, the convergence takes place at realistic SNR values. Furthermore, in this case the diversity gain can also be used to estimate the outage probability with reasonable accuracy. The multiplexing gain definition via the high-SNR asymptote of the mean capacity (as in [1]) results in very slow convergence for moderate to large systems (as l/ln(SNR) circ2) and, hence, the asymptotic DMT cannot be used at realistic SNR values. For this definition, the high-SNR threshold increases exponentially in the number of antennas and in the multiplexing gain. For correlated keyhole channel, the diversity gain is shown to decrease with correlation and power imbalance of the channel. While the SNR-asymptotic DMT of Zheng and Tse does not capture this effect, the size-asymptotic DMT does.
Autotuning CUDA compiler parameters for heterogeneous applications using the OpenTuner framework

A Graphics Processing Unit (GPU) is a parallel computing coprocessor specialized in accelerating vector operations. The enormous heterogeneity of parallel computing platforms justifies and motivates the development of automated optimization tools and techniques. The Algorithm Selection Problem consists in finding a combination of algorithms, or a configuration of an algorithm, that optimizes the solution of a set of problem instances. An autotuner solves the Algorithm Selection Problem using search and optimization techniques.
Ablation of human nail by pulsed lasers

The hard and resistant structure of the nail plate forms a natural barrier that limits the penetration of topical drugs. To overcome this barrier, the use of pulsed laser systems has been suggested. The purpose of this study was to evaluate the effect of four laser systems on nail plate ablation rates, ablation efficiencies, and subsequent craters morphology.
Accumulation Variability in the Antarctic Peninsula: The Role of Large-Scale Atmospheric Oscillations and Their Interactions*

AbstractA new ice core drilled in 2010 to bedrock from the Bruce Plateau (BP) on the Antarctic Peninsula (AP) provides a high temporal resolution record of environmental conditions in this region. The extremely high annual accumulation rate at this site facilitates analysis of the relationships between annual net accumulation An on the BP and large-scale atmospheric oscillations. Over the last ~45 years, An on the BP has been positively correlated with both the southern annular mode (SAM) and Southern Oscillation index (SOI). Extending this analysis back to 1900 reveals that these relationships are not temporally stable, and they exhibit major shifts in the late-1940s and the mid-1970s that are contemporaneous with phase changes in the Pacific decadal oscillation (PDO). These varying multidecadal characteristics of the An–oscillation relationships are not apparent when only data from the post-1970s era are employed. Analysis of the longer ice core record reveals that the influence of the SAM on An depends.
Respiratory Sinus Arrhythmia as an Index of Vagal Activity during Stress in Infants: Respiratory Influences and Their Control

Respiratory sinus arrhythmia (RSA) is related to cardiac vagal outflow and the respiratory pattern. Prior infant studies have not systematically examined respiration rate and tidal volume influences on infant RSA or the extent to which infants' breathing is too fast to extract a valid RSA. We therefore monitored cardiac activity, respiration, and physical activity in 23 six-month old infants during a standardized laboratory stressor protocol. On average, 12.6% (range 0–58.2%) of analyzed breaths were too short for RSA extraction. Higher respiration rate was associated with lower RSA amplitude in most infants, and lower tidal volume was associated with lower RSA amplitude in some infants. RSA amplitude corrected for respiration rate and tidal volume influences showed theoretically expected strong reductions during stress, whereas performance of uncorrected RSA was less consistent. We conclude that stress-induced changes of peak-valley RSA and effects of variations in breathing patterns on RSA can be determined for a representative percentage of infant breaths. As expected, breathing substantially affects infant RSA and needs to be considered in studies of infant psychophysiology.
High-resolution satellite image classification and segmentation using Laplacian graph energy

Many segmentation algorithms describe images in terms of a hierarchy of regions. Although such hierarchies can produce state of the art segmentations and can be used in the classification, they often contain more data than is required for an efficient description which cause increased complexity and time cost. In this paper, we proposed a new hierarchical segmentation method which apply Laplacian graph energy as a generic measure to reduce the number of levels and regions in the hierarchy by an order of magnitude with little or no loss in performance. We apply our method in remote sensing image analysis.
Quantum interactive proofs with weak error bounds

This paper proves that the computational power of quantum interactive proof systems, with a double-exponentially small gap in acceptance probability between the completeness and soundness cases, is precisely characterized by EXP, the class of problems solvable in exponential time by deterministic Turing machines. This fact, and our proof of it, has implications concerning quantum and classical interactive proof systems in the setting of unbounded error that include the following: • Quantum interactive proof systems are strictly more powerful than their classical counterparts in the unbounded-error setting unless PSPACE = EXP, as even unbounded error classical interactive proof systems can be simulated in PSPACE. • The recent proof of Jain, Ji, Upadhyay, and Watrous (STOC 2010) establishing QIP = PSPACE relies heavily on the fact that the quantum interactive proof systems defining the class QIP have bounded error. Our result implies that some nontrivial assumption on the error bounds for quantum interactive proofs is unavoidable to establish this result (unless PSPACE = EXP). • To prove our result, we give a quantum interactive proof system for EXP with perfect completeness and soundness error 1--2-2poly, for which the soundness error bound is provably tight. This establishes another respect in which quantum and classical interactive proof systems differ, because such a bound cannot hold for any classical interactive proof system: distinct acceptance probabilities for classical interactive proof systems must be separated by a gap that is at least (single-)exponentially small. We also study the computational power of a few other related unbounded-error complexity classes.
Automated X-Ray Object Recognition Using an Efficient Search Algorithm in Multiple Views

In order to reduce the security risk of a commercial aircraft, passengers are not allowed to take certain items in their carry-on baggage. For this reason, human operators are trained to detect prohibited items using a manually controlled baggage screening process. In this paper, we propose the use of an automated method based on multiple X-ray views to recognize certain regular objects with highly defined shapes and sizes. The method consists of two steps: 'monocular analysis', to obtain possible detections in each view of a sequence, and 'multiple view analysis', to recognize the objects of interest using matchings in all views. The search for matching candidates is efficiently performed using a lookup table that is computed off-line. In order to illustrate the effectiveness of the proposed method, experimental results on recognizing regular objects --clips, springs and razor blades-- in pen cases are shown achieving around 93% accuracy for 120 objects. We believe that it would be possible to design an automated aid in a target detection task using the proposed algorithm.
Technological Advances in Bifidobacterial Molecular Genetics: Application to Functional Genomics and Medical Treatments

Bifidobacteria are well known as beneficial intestinal bacteria that exert health-promoting effects in humans. In addition to physiological and immunological investigations, molecular genetic technologies have been developed and have recently started to be applied to clarify the molecular bases of host-Bifidobacterium interactions. These technologies include transformation technologies and Escherichia coli-Bifidobacterium shuttle vectors that enable heterologous gene expression. In this context, a plasmid artificial modification method that protects the introduced plasmid from the restriction system in host bifidobacteria has recently been developed to increase transformation efficiency. On the other hand, targeted gene inactivation systems, which are vital for functional genomics, seemed far from being practically applicable in bifidobacteria. However, remarkable progress in this technology has recently been achieved, enabling functional genomics in bifidobacteria. Integrated use of these molecular genetic technologies with omics-based analyses will surely boost characterization of the molecular basis underlying beneficial effects of bifidobacteria. Applications of recombinant bifidobacteria to medical treatments have also progressed.
Model Theory: Third Edition (Dover Books On Mathematics) By C.C. Chang;H. Jerome Keisler;Mathematics

If looking for a book by C.C. Chang;H. Jerome Keisler;Mathematics Model Theory: Third Edition (Dover Books on Mathematics) in pdf format, then you've come to the faithful site. We presented the full option of this ebook in PDF, ePub, txt, DjVu, doc forms. You can read by C.C. Chang;H. Jerome Keisler;Mathematics online Model Theory: Third Edition (Dover Books on Mathematics) or downloading. As well as, on our site you may reading the instructions and other artistic books online, either load theirs. We will draw consideration what our site not store the book itself, but we provide link to the website whereat you can downloading either read online. If you need to downloading by C.C. Chang;H. Jerome Keisler;Mathematics pdf Model Theory: Third Edition (Dover Books on Mathematics) , then you've come to the right site. We own Model Theory: Third Edition (Dover Books on Mathematics) doc, ePub, DjVu, PDF, txt forms. We will be happy if you get back to us afresh.
Visualization of cytosolic ribosomes on the surface of mitochondria by electron cryo‐tomography

We employed electron cryo‐tomography to visualize cytosolic ribosomes on the surface of mitochondria. Translation‐arrested ribosomes reveal the clustered organization of the TOM complex, corroborating earlier reports of localized translation. Ribosomes are shown to interact specifically with the TOM complex, and nascent chain binding is crucial for ribosome recruitment and stabilization. Ribosomes are bound to the membrane in discrete clusters, often in the vicinity of the crista junctions. This interaction highlights how protein synthesis may be coupled with transport. Our work provides unique insights into the spatial organization of cytosolic ribosomes on mitochondria.
Ginsenoside-Rd Promotes Neurite Outgrowth of PC12 Cells through MAPK/ERK- and PI3K/AKT-Dependent Pathways

Panax ginseng is a famous herbal medicine widely used in Asia. Ginsenosides have been identified as the principle active ingredients for Panax ginseng’s biological activity, among which ginsenoside Rd (Rd) attracts extensive attention for its obvious neuroprotective activities. Here we investigated the effect of Rd on neurite outgrowth, a crucial process associated with neuronal repair. PC12 cells, which respond to nerve growth factor (NGF) and serve as a model for neuronal cells, were treated with different concentrations of Rd, and then their neurite outgrowth was evaluated. Our results showed that 10 μM Rd significantly increased the percentages of long neurite- and branching neurite-bearing cells, compared with respective controls. The length of the longest neurites and the total length of neurites in Rd-treated PC12 cells were much longer than that of respective controls. We also showed that Rd activated ERK1/2 and AKT but not PKC signalings, and inhibition of ERK1/2 by PD98059 or/and AKT by LY294002 effectively attenuated Rd-induced neurite outgrowth. Moreover, Rd upregulated the expression of GAP-43, a neuron-specific protein involved in neurite outgrowth, while PD98059 or/and LY294002 decreased Rd-induced increased GAP-43 expression. Taken together, our results provided the first evidence that Rd may promote the neurite outgrowth of PC12 cells by upregulating GAP-43 expression via ERK- and ARK-dependent signaling pathways.
Frequency Reconfigurable and Miniaturized Substrate Integrated Waveguide Interdigital Capacitor (SIW-IDC) Antenna

A novel frequency reconfigurable substrate integrated waveguide-interdigital capacitor (SIW-IDC) antenna is presented. The antenna is designed based on a composite right/left-handed (CRLH) resonator, which is realized by the SIW-IDC. Thanks to CRLH characteristics, the antenna size is reduced. Since the IDC determines the resonant frequency, a varactor diode is embedded on the interdigital slot of the short-ended SIW. Its zeroth-order resonance (ZOR) frequency is varied from 4.13 GHz to 4.50 GHz by changing the bias voltage from 0 V to 36 V while keeping good impedance matching better than 15 dB. The radiation performance is numerically and experimentally investigated. Very good agreements between the simulated and measured S-parameters and radiation patterns are observed.
A Text-Based Approach to the ImageCLEF 2010 Photo Annotation Task

The challenges of searching the increasingly large collections of digital images which are appearing in many places mean that automated annotation of images is becoming an important technology. We describe our participation in the ImageCLEF 2010 Visual Concept Detection and Annotation Task. Our approach used only the textual features (Flickr user tags and EXIF information) provided with the images to perform automatic annotation. Our method explores the use of a combination of techniques to address the annotation problem. Our results indicate that the techniques works reasonably given the limitations inherent in using only textual data for this task. We identify the drawbacks of our approach and how these might be addressed and optimized in further work.
Modeling of I-, T- and V-Shaped Microcantilevers for Environmental Monitoring

This paper describes a model of microcantilever to determine the optimal dimensions that can be used for environmental monitoring. Three types, which are usually used i.e., I-, T- and V-shaped microcantilevers, are considered. The microcantilevers work in dynamic mode in which their resonance frequencies depend on both spring constant and effective mass. It can be seen that the spring constant and effective mass of the microcantilever change when the structure is changed even the size is same. In consequent, the sensor sensitivity is also found to be different each other. The V-shaped microcantilever is more sensitive than I- and T-shaped ones. Moreover, the simulation results show that the microcantilever with sizes of length 10 µm, width 5 µm and thickness 100 nm is good enough to detect molecule gas with the mass of less than femtogram.
Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery

MOTIVATION Signaling pathways control a large variety of cellular processes. However, currently, even within the same database signaling pathways are often curated at different levels of detail. This makes comparative and cross-talk analyses difficult. RESULTS We present SignaLink, a database containing eight major signaling pathways from Caenorhabditis elegans, Drosophila melanogaster and humans. Based on 170 review and approximately 800 research articles, we have compiled pathways with semi-automatic searches and uniform, well-documented curation rules. We found that in humans any two of the eight pathways can cross-talk. We quantified the possible tissue- and cancer-specific activity of cross-talks and found pathway-specific expression profiles. In addition, we identified 327 proteins relevant for drug target discovery. CONCLUSIONS We provide a novel resource for comparative and cross-talk analyses of signaling pathways. The identified multi-pathway and tissue-specific cross-talks contribute to the understanding of the signaling complexity in health and disease, and underscore its importance in network-based drug target selection. AVAILABILITY http://SignaLink.org.
The granular jamming integrated actuator

Soft robotics have opened a new field of flexible and dexterous manipulators. However, actuators to maximize a dexterous robot's workspace remain in their infancy. For a snake-like robot, actuation is emphasized on joint bending, which is the control of the bending angle and curvature. State of the art actuators can only independently control one of the two. This paper presents a granular jamming integrated actuator (JIA) which can control both the bending angle and curvature of joint independently. The JIA achieves this with its design, which consists of a granular-filled, bellowed walled membrane wrapped in a braided fiber sleeve. When inflated with positive pressure, the JIA expands and elongates in the axial direction. When the air flow is reversed and vacuum is achieved, the granules within the actuator stiffen it. By using granular jamming, JIAs in a bundle can restrict the movement of a neighboring elongating actuator. Our tests show that a bundle of this actuator type can vary its bending curvature, while maintaining a desired angle, by modulating the pressure differential between actuators within a bundle.
The effects of horse-riding simulator exercise and Kendall exercise on the forward head posture

[Purpose] The aim of this study was to examine the effects of horse-riding simulator exercise and Kendall exercise on forward head posture. [Subjects and Methods] Thirty elderly college students with a forward head posture were randomly divided into two groups for 15 persons each, a horse-riding simulator group and Kendall exercise group, and performed exercise for eight weeks. [Results] The horse-riding simulator group and Kendall exercise group showed significant differences after the intervention in New York state posture rating, craniovertebral angle, and cranial rotation angle. The horse-riding simulator group showed a significantly smaller value than the Kendall exercise group for New York state posture rating evaluation after the intervention. [Conclusion] The results of this study indicate that horse-riding simulator exercise is more effective on forward head posture than Kendall exercise. Therefore, horse-riding simulator exercise can be used as a new simple treatment method for the ever-growing forward head posture.
The exceptional sediment load of fine-grained dispersal systems: Example of the Yellow River, China

We analyze why the sediment discharges of fine-grained rivers are an order of magnitude larger than predicted by current theory. Sedimentary dispersal systems with fine-grained beds are common, yet the physics of sediment movement within them remains poorly constrained. We analyze sediment transport data for the best-documented, fine-grained river worldwide, the Huanghe (Yellow River) of China, where sediment flux is underpredicted by an order of magnitude according to well-accepted sediment transport relations. Our theoretical framework, bolstered by field observations, demonstrates that the Huanghe tends toward upper-stage plane bed, yielding minimal form drag, thus markedly enhancing sediment transport efficiency. We present a sediment transport formulation applicable to all river systems with silt to coarse-sand beds. This formulation demonstrates a remarkably sensitive dependence on grain size within a certain narrow range and therefore has special relevance to silt-sand fluvial systems, particularly those affected by dams.
Effects of radiation on materials: 18. international symposium

The papers presented in this STP are organized in 14 sections, seven on pressure vessel steels, two on austenitic alloys, one each on other structural alloys, ferritic and ferritic-martensitic alloys, copper and copper alloys, and vanadium alloys, and one section with papers on aluminum, beryllium, zirconium, and sapphire. The organization of the sections generally reflects that of the technical sessions of the symposium. Separate abstracts were prepared for most papers in this book.