Miracle-dz/UniFAR-FTUs huggingface dataset:
Study protocol for a randomised, controlled platform trial estimating the effect of autobiographical Memory Flexibility training (MemFlex) on relapse of recurrent major depressive disorder

Introduction Major depressive disorder (MDD) is a chronic condition. Although current treatment approaches are effective in reducing acute depressive symptoms, rates of relapse are high. Chronic and inflexible retrieval of autobiographical memories, and in particular a bias towards negative and overgeneral memories, is a reliable predictor of relapse. This randomised controlled single-blind trial will determine whether a therapist-guided self-help intervention to ameliorate autobiographical memory biases using Memory Flexibility training (MemFlex) will increase the experience of depression-free days, relative to a psychoeducation control condition, in the 12 months following intervention. Methods and analysis Individuals (aged 18 and above) with a diagnosis of recurrent MDD will be recruited when remitted from a major depressive episode. Participants will be randomly allocated to complete 4 weeks of a workbook providing either MemFlex training, or psychoeducation on factors that increase risk of relapse. Assessment of diagnostic status, self-report depressive symptoms, depression-free days and cognitive risk factors for depression will be completed post-intervention, and at 6 and 12 months follow-up. The cognitive target of MemFlex will be change in memory flexibility on the Autobiographical Memory Test- Alternating Instructions. The primary clinical endpoints will be the number of depression-free days in the 12 months following workbook completion, and time to depressive relapse. Ethics and dissemination Ethics approval has been granted by the NHS National Research Ethics Committee (East of England, 11/H0305/1). Results from this study will provide a point-estimate of the effect of MemFlex on depressive relapse, which will be used to inform a fully powered trial evaluating the potential of MemFlex as an effective, low-cost and low-intensity option for reducing relapse of MDD. Trial registration number NCT02614326.
Influence of Work Pace on Upper Extremity Kinematics and Muscle Activity in a Short-Cycle Repetitive Pick-and-Place Task

Objectives This study investigated the extent to which controlled changes in work pace in a cyclic pick-and-place task influence upper extremity kinematics and muscle activity, and whether an effect depends on working height. Methods Thirteen participants performed the task for 4 min at each of five work paces ranging from 8 to 12 cycles·min-1 in each of two experimental conditions where the hand was moved horizontally with an average upper arm elevation of 30° and 50°, respectively. For each work cycle, we calculated the average and standard deviation of the upper arm elevation angle and the activity of the trapezius and deltoid muscles, as well as the angular peak velocity. We summarized these seven variables by calculating averages across cycles and cycle-to-cycle variabilities. Results At 30° arm elevation, pace significantly influenced within-cycle angle variation, cycle-to-cycle variability of the average angle, angular peak velocity, and cycle-to-cycle variability of peak velocity. However, only angular peak velocity increased monotonically across all paces from 8 to 12 cycles·min-1). Average activity in the trapezius and the deltoid were the only muscle activity variables to increase consistently with pace. These effects of work pace did not change with working height. Conclusion The present study did not find any consistent work pace effect on upper extremity kinematics and muscle activity, in spite of a comprehensive empirical basis compared to previous literature. While our results suggest that work pace may not be of critical concern in an occupational health context, we encourage further studies verifying or disproving this notion.
Prognostic value of FOXM1 in solid tumors: a systematic review and meta-analysis

Accumulated studies have provided controversial evidences of the association between Forkhead Box M1 (FOXM1) expression and survival of human solid tumors. To address this inconsistency, we performed a meta-analysis with 23 studies identified from PubMed and Medline. We found elevated FOXM1-protein expression was significantly associated with worse 3-year overall survival (OS) (OR = 3.30, 95% CI = 2.56 to 4.25, P < 0.00001) 5-year OS (OR =3.35, 95% CI = 2.64 to 4.26, P < 0.00001) and 10-year OS (OR = 5.24, 95% CI = 2.61 to 10.52, P < 0.00001) of human solid tumors. Similar results were observed when disease free survival (DFS) were analyzed. Subgroup analysis showed that FOXM1 overexpression was associated with poor prognosis of colorectal cancer, gastric cancer, hepatic cancer, lung cancer and ovarian cancer. High expression level of FOXM1 was also associated with advanced tumor stage. In conclusion, elevated FOXM1 expression is associated with poor survival in most solid tumors. FOXM1 is a potential biomarker for prognosis prediction and a promising therapeutic target in human solid tumors.
Membrane protein recycling from the vacuole/lysosome membrane

The lysosome (or vacuole in yeast) is the central organelle responsible for cellular degradation and nutrient storage. Lysosomes receive cargo from the secretory, endocytic, and autophagy pathways. Many of these proteins and lipids are delivered to the lysosome membrane, and some are degraded in the lysosome lumen, whereas others appear to be recycled through unknown pathways. In this study, we identify the transmembrane autophagy protein Atg27 as a physiological cargo recycled from the vacuole. We reveal that Atg27 is delivered to the vacuole membrane and then recycled using a two-step recycling process. First, Atg27 is recycled from the vacuole to the endosome via the Snx4 complex and then from the endosome to the Golgi via the retromer complex. During the process of vacuole-to-endosome retrograde trafficking, Snx4 complexes assemble on the vacuolar surface and recognize specific residues in the cytoplasmic tail of Atg27. This novel pathway maintains the normal composition and function of the vacuole membrane.
Chapter 6 Meta-Modelling Techniques Towards Virtual Production Intelligence

Decision making for competitive production in high-wage countries is a daily challenge where rational and irrational methods are used. The design of decision making processes is an intriguing, discipline spanning science. However, there are gaps in understanding the impact of the known mathematical and procedural methods on the usage of rational choice theory. Following Benjamin Franklin’s rule for decision making formulated in London 1772, he called “Prudential Algebra” with the meaning of prudential reasons, one of the major ingredients of Meta-Modelling can be identified finally leading to one algebraic value labelling the results (criteria settings) of alternative decisions (parameter settings). This work describes the advances in Meta-Modelling techniques applied to multidimensional and multi-criterial optimization in laser processing, e.g. sheet metal cutting, including the generation of fast and frugal Meta-Models with controlled error based on model reduction in mathematical physical or numerical model reduction. Reduced Models are derived to avoid any unnecessary complexity. The advances of the Meta-Modelling technique are based on three main concepts: (i) classification methods that decomposes the space of process parameters into feasible and non-feasible regions facilitating optimization, or monotone regions (ii) smart sampling methods for faster generation of a Meta-Model, and (iii) a method for multi-dimensional interpolation using a radial basis function network continuously mapping the discrete, multi-dimensional sampling set that contains the process parameters as well as the quality criteria. Both, model reduction and optimization on a multi-dimensional parameter space are improved by exploring the data mapping within an advancing “Cockpit” for Virtual Production Intelligence. W. Schulz (&) Fraunhofer Institute for Laser Technology ILT, Steinbachstr. 15, 52074 Aachen, Germany e-mail: wolfgang.schulz@ilt.fraunhofer. de T.A. Khawli Nonlinear Dynamics of Laser Processing of RWTH Aachen, Steinbachstr. 15, 52074 Aachen, Germany e-mail: toufik.al.khawli@ilt.fraunhofer. de © The Author(s) 2015 C. Brecher (ed.), Advances in Production Technology, Lecture Notes in Production Engineering, DOI 10.1007/978-3-319-12304-2_6 69
In-Hospital Outcomes and Long-Term Follow-Up after Percutaneous Transcatheter Closure of Postinfarction Ventricular Septal Defects

Postinfarction ventricular septal defects (VSD) represent a devastating complication of acute myocardial infarction and are associated with high mortality. Percutaneous interventional closure of postinfarction VSD has been proposed as a potential alternative to surgery. The study aimed to evaluate the therapeutic safety and efficacy of percutaneous interventional closure of postinfarction ventricular septal defects (VSD). Each patient was assigned to one of two groups, based on whether they died during hospitalization (death group) or survived (survival group) in this retrospective study. In-hospital and follow-up data were analyzed. Placement of the VSD occluder was successful in 12 procedures (80%). The mean defect size was 14.20 ± 4.89 mm. Compared to the patients who died, those who survived had higher systolic blood pressure, diastolic blood pressure, and left ventricular ejection fraction upon admission, as well as lower pulmonary/systemic flow ratio and shorter time from acute myocardial infarction to procedure. The incidence of cardiac shock and class IV heart failure was lower in the survival group than in the death group, and these factors correlated with in-hospital and 30-day mortality. Percutaneous closure of postinfarction VSD is an effective technique, which can be performed with a high procedural success rate.
A cyber-physical system based framework for motor rehabilitation after stroke

Cyber-physical system (CPS) is conveyed as a networked systems which can interact with people in a higher level through more modalities with integration of computation, communication and control. This paper presents a novel framework, based on CPS concept, for a networked interactive home based intelligent motor rehabilitation system to facilitate functional recovery post-stroke. A hierarchical architecture is proposed in this framework. Patients use proper rehabilitation appliances to conduct continuous, repetitive rehabilitation trainings while wireless sensor networks (WSN) collect data related to the patients' functional activities. Higher level devices do data processing and exchange information with networked therapists and other patients on latest available therapies, valuable experts' experiences, and experience generated in the therapy process. Within this framework, it is expected that important information and resources can be utilized in the rehabilitation stages more efficiently for an individual subject. The design, implementation and future work about this CPS-based framework are discussed in this paper.
THE EFFECTS OF STRESS RATIO ON THE GROWTH BEHAVIOUR OF SMALL FATIGUE CRACKS IN AN ALUMINUM ALLOY 7075‐T6 (WITH SPECIAL INTEREST IN STAGE I CRACK GROWTH)

— The growth behaviour of small fatigue cracks has been investigated on aluminum alloy 7075-T6 at stress ratios R of 0, −1 and −2. The effects of stress ratio are discussed with special interest in the stage I region of small crack growth. Cracks which initiated at R=−1 and −2, grew by a stage I mechanism up to a certain depth followed by stage II crack growth. The stage I to stage II transition occurred under a constant maximum stress intensity factor which was approximately consistent with the threshold effective stress intensity range, λKeff,th, for large cracks. At R= 0, on the other hand, stage I crack growth was not observed because of crack initiation at inclusions. Small cracks grew more rapidly than large cracks subjected to the same nominal stress intensity ranges at all the stress ratios, and they grew below the threshold stress intensity range, λKth, for large cracks. Stage I cracks, in particular, showed much higher growth rates than large cracks and grew even below λKeff,th. It is suggested that stage II crack growth rates should be characterized in terms of an effective stress intensity range, while a micromechanics approach will be necessary to evaluate stage I crack growth rates.
Nano-machining of highly oriented pyrolytic graphite using conductive atomic force microscope tips and carbon nanotubes

Sub-100 nm holes were made on a highly oriented pyrolytic graphite (HOPG) surface using a metal-coated atomic force microscope (AFM) tip and carbon nanotube. HOPG was used as a substrate (work piece) and a metal-coated (10 nm Cr/30 nm Au) Si AFM tip served as the other electrode. A negative voltage pulse was applied to the AFM tip to fabricate holes as small as 10 nm in diameter on the HOPG surface with a depth of 0.34 nm, which corresponds to a single layer of graphene. We also explored an individual multi-walled carbon nanotube (MWNT) attached to the AFM tip for nanoscale machining. Unlike the pyramidal shape of the AFM tip, the high aspect ratio of a carbon nanotube can make it possible to form deeper holes at even smaller surface diameter. The hole-formation mechanism is related to the chemical reaction of graphite with adsorbed water and tunneling electrons from the tip to substrate.
Towards a Formal Model for Software Tamper Resistance

A major challenge in software protection is the problem of tampering where an adversary modifies a program and uses it in a way that was not intended or desired. Several ad hoc techniques for software tamper resistance have been proposed, some of which provide a significant level of resilience against tampering. However, the literature lacks a formal definition of tampering that takes into account a model of the attacker’s goals. One effect of this lack is the inability of easily comparing the actual efficacy of proposed tamper resistance mechanisms and evaluating the practical limits of tamper resistance. This paper is a step towards addressing this shortcoming. We consider the two players: the defender who wishes to protect the program, and an adversary who wishes to modify the program as well as the assets embedded within the program to his advantage. We propose a way of expressing the intent of the defender and the attacker based on predicates defined over program traces. Based on these expressions, we present formal definitions for software tamper resistance, and software tamper verification. With a practical tamper verification scheme, we show how this formal model can be used in a reactive protection setting.
Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.

BACKGROUND DNA methylation is influenced by diet and single nucleotide polymorphisms (SNPs), and methylation modulates gene expression. OBJECTIVE We aimed to explore whether the gene-by-diet interactions on blood lipids act through DNA methylation. DESIGN We selected 7 SNPs on the basis of predicted relations in fatty acids, methylation, and lipids. We conducted a meta-analysis and a methylation and mediation analysis with the use of data from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium and the ENCODE (Encyclopedia of DNA Elements) consortium. RESULTS On the basis of the meta-analysis of 7 cohorts in the CHARGE consortium, higher plasma HDL cholesterol was associated with fewer C alleles at ATP-binding cassette subfamily A member 1 (ABCA1) rs2246293 (β = -0.6 mg/dL, P = 0.015) and higher circulating eicosapentaenoic acid (EPA) (β = 3.87 mg/dL, P = 5.62 × 10(21)). The difference in HDL cholesterol associated with higher circulating EPA was dependent on genotypes at rs2246293, and it was greater for each additional C allele (β = 1.69 mg/dL, P = 0.006). In the GOLDN (Genetics of Lipid Lowering Drugs and Diet Network) study, higher ABCA1 promoter cg14019050 methylation was associated with more C alleles at rs2246293 (β = 8.84%, P = 3.51 × 10(18)) and lower circulating EPA (β = -1.46%, P = 0.009), and the mean difference in methylation of cg14019050 that was associated with higher EPA was smaller with each additional C allele of rs2246293 (β = -2.83%, P = 0.007). Higher ABCA1 cg14019050 methylation was correlated with lower ABCA1 expression (r = -0.61, P = 0.009) in the ENCODE consortium and lower plasma HDL cholesterol in the GOLDN study (r = -0.12, P = 0.0002). An additional mediation analysis was meta-analyzed across the GOLDN study, Cardiovascular Health Study, and the Multi-Ethnic Study of Atherosclerosis. Compared with the model without the adjustment of cg14019050 methylation, the model with such adjustment provided smaller estimates of the mean plasma HDL cholesterol concentration in association with both the rs2246293 C allele and EPA and a smaller difference by rs2246293 genotypes in the EPA-associated HDL cholesterol. However, the differences between 2 nested models were NS (P > 0.05). CONCLUSION We obtained little evidence that the gene-by-fatty acid interactions on blood lipids act through DNA methylation.
Effect of diazoxide on Friedreich ataxia models

Friedreich ataxia (FRDA) is an inherited recessive disorder caused by a deficiency in the mitochondrial protein frataxin. There is currently no effective treatment for FRDA available, especially for neurological deficits. In this study, we tested diazoxide, a drug commonly used as vasodilator in the treatment of acute hypertension, on cellular and animal models of FRDA. We first showed that diazoxide increases frataxin protein levels in FRDA lymphoblastoid cell lines, via the mammalian target of rapamycin (mTOR) pathway. We then explored the potential therapeutic effect of diazoxide in frataxin-deficient transgenic YG8sR mice and we found that prolonged oral administration of 3 mpk/d diazoxide was found to be safe, but produced variable effects concerning efficacy. YG8sR mice showed improved beam walk coordination abilities and footprint stride patterns, but a generally reduced locomotor activity. Moreover, they showed significantly increased frataxin expression, improved aconitase activity, and decreased protein oxidation in cerebellum and brain mitochondrial tissue extracts. Further studies are needed before this drug should be considered for FRDA clinical trials.
Towards high performance continuous Mandarin digit string recognition

In this paper, we address the problem of high performance speaker-independent continuous Mandarin digital string recognizer and focus on exploiting context information and prosody knowledge. Data-driven decision tree method to train tri-phone acoustic model was proposed. According to Chinese language property, digital specific question set was designed and the derived tri-phone model is more accurate to describe acoustic observation. For prosody cue, a novel Gaussian Mixture Density Duration Model (GMDDM) was presented. Unlike traditional normalizing or single parameter strategy, proposed duration model is context independent. The context variation is naturally embodied into multiple Gaussian distribution mixture. The number of mixture is automatically selected according maximum likelihood criteria. This simple but effective duration model’s likelihood score is combined with acoustic score as heuristic information for the backward A* decoding of word graph. Experimental results show the tri-phone acoustic model could lead to average 12.9% reduce of string error rate. When GMDDM model is applied, the string error rate is further reduced by 22.7%, which demonstrates the very usefulness of GMDDM model.
What Can We Learn about Workplace Heat Stress Management from a Safety Regulator Complaints Database?

Heat exposure can be a health hazard for many Australian workers in both outdoor and indoor situations. With many heat-related incidents left unreported, it is often difficult to determine the underlying causal factors. This study aims to provide insights into perceptions of potentially unsafe or uncomfortably hot working conditions that can affect occupational health and safety using information provided by the public and workers to the safety regulator in South Australia (SafeWork SA). Details of complaints regarding heat exposure to the regulator’s “Help Centre” were assembled in a dataset and the textual data analysed thematically. The findings showed that the majority of calls relate to indoor work environments such as kitchens, factories, and warehouses. The main themes identified were work environment, health effects, and organisational issues. Impacts of hot working conditions ranged from discomfort to serious heat-related illnesses. Poor management practices and inflexibility of supervisors featured strongly amongst callers’ concerns. With temperatures predicted to increase and energy prices escalating, this timely study, using naturalistic data, highlights accounts of hot working conditions that can compromise workers’ health and safety and the need for suitable measures to prevent heat stress. These could include risk assessments to assess the likelihood of heat stress in workplaces where excessively hot conditions prevail.
Ativação in vitro de neutrófilos expostos a stents carotídeos de nitinol e cobalto-cromo

Introduction: Carotid artery stenting (CAS) is an alternative treatment for atherosclerotic occlusive disease. In the medium term, the main complication of CAS is the in-stent restenosis (4.8% in two years), for which the main triggering factor is the foreign body inflammatory response to the carotid stent (CS). Objectives: There are different types of CS available, and they basically consist of two different alloys: cobalt-chrome (Wallstent®) and Nitinol (Protégé®). This study compared the structural characteristics and the inflammatory activation of neutrophils when exposed to both types of CS, checking the production of free radicals with the use of optical spectroscopy. Materials and methods: 20 ml of blood collected from 19 healthy volunteer patients were centrifuged using the Percoll method for neutrophil separation. Neutrophils were exposed to the stent surface for 40-minute periods in a nitroblue tetrazolium (NBT) solution. After the incubation period, the results were transmittance-measured using an optical spectrophotometer at a 550 nm wavelength. After that, a portion of each sample was sent for scanning optical microscopy and morphophysiological analysis of the CS and the adherent neutrophils. Results: The spectrophotometer reading showed that the Nitinol (NT) alloy was responsible for a statistically significant increased production of reactive species of oxygen when compared to the cobalt-chrome (CbCr) alloy (0.114 +/0.062 vs. 0.085 +/0.050 transmittance level, p = 0.02 and CI 95% 0.0052 to 0.0534). Scanning electron microscope images showed that the NT CS mesh has rectangular cross sections, and the CbCr CS mesh has cylindrical cross sections.