Miracle-dz/UniFAR-FTUs huggingface dataset:
Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells

The RNA-binding protein tristetraprolin (TTP) promotes rapid decay of mRNAs bearing 3' UTR AU-rich elements (ARE). In many cancer types, loss of TTP expression is observed allowing for stabilization of ARE-mRNAs and their pathologic overexpression. Here we demonstrate that histone deacetylase (HDAC) inhibitors (Trichostatin A, SAHA and sodium butyrate) promote TTP expression in colorectal cancer cells (HCA-7, HCT-116, Moser and SW480 cells) and cervix carcinoma cells (HeLa). We found that HDAC inhibitors-induced TTP expression, promote the decay of COX-2 mRNA, and inhibit cancer cell proliferation. HDAC inhibitors were found to promote TTP transcription through activation of the transcription factor Early Growth Response protein 1 (EGR1). Altogether, our findings indicate that loss of TTP in tumors occurs through silencing of EGR1 and suggests a therapeutic approach to rescue TTP expression in colorectal cancer.
Seasonal Solow Residuals and Christmas: A Case for Labor Hoarding and Increasing Returns

In aggregate unadjusted data, measured Solow residuals exhibit large seasonal variations. Total Factor Productivity grows rapidly in the fourth quarter at an annual rate of 16 percent and regresses sharply in the first quarter at an annual rate of -24 percent. This paper considers two potential explanations for the measured seasonal variation in the Solow residual: labor hoarding and increasing returns to scale. Using a specification that allows for no exogenous seasonal variation in technology and a single seasonal demand shift in the fourth quarter, we ask the following question: how much of the total seasonal variation in the measured Solow residual can be explained by Christmas? The answer to this question is surprising. With increasing returns and time varying labor effort, Christmas is sufficient to explain the seasonal variation in the Solow residual, consumption, average productivity, and output in all four quarters. The authors' analysis of seasonally unadjusted data uncovers important roles for labor hoarding and increasing returns which are difficult to identify in adjusted data.
Future self-appraisals and global self-esteem: Who benefits more from thinking about the future, and why?

Abstract People tend to think positively about their future selves. However, it remains unclear to what extent this tendency depends on the positivity of their current self-appraisal. To study this problem, we employed the assumptions of construal level theory, the concept of self-enhancement, and the assumptions of temporal self-appraisal theory, and we examined the role of global self-esteem in the relationship between temporal distance and future self-appraisals measured in absolute (Study 1), comparative temporal (Study 2), or comparative social (Study 3) ways. In all three studies, when assessed in terms of specific dimensions, future self-appraisals increased with temporal distance only in people with low self-esteem, but when assessed in terms of general dimensions, self-appraisals were higher in the distant compared to the near future irrespective of self-esteem level.
Survey on Multi Authority Attribute Based Encryption for Personal Health Record in Cloud Computing

-Personal Health Record (PHR) service is an emerging model for health information exchange. PHR system allows patients to create, control manage, and share their health information with other users as well as healthcare providers like Google eHealth. A PHR service is likely to be hosted by third-party cloud service providers in order to enhance its interoperability. The access control and privacy management is a complex task in the patient health record management process. Data owners update the personal data into third party cloud data centers. Issues such as risks of privacy exposure, scalability in key management, data loss, flexible access efficient user revocation and data theft, have remained the most important . To achieve fine-grained and scalable data access control for PHRs, Attribute Based Encryption (ABE) techniques to encrypt each patient’s PHR file. In Key Policy Attribute-Based Encryption (KP-ABE), a single data owner can encrypt her data and share with multiple authorized users by distributing keys to them. KP-ABE achieves low amortized overhead. Multiple data owners can access the same data values. Multi authority attribute based encryption could be further enhanced to proactive Multi authority attribute based encryption.
Emotional and Behavioral Disorders (EBD) and Achievements of Grade 1Pupils

Emotional and behavioral disorders are potential causes of disciplinary problems in the classroom. The main interest of the study is the EBD and achievements of Grade 1 pupils in public schools of South Cotabato. About 210 Grade One pupils and teachers were involved as subjects and respondents of this inquiry. A questionnaire in EBD was given to teachers for them to carefully assess the pupils' ODD, CD and ADHD level. The survey tools were modeled after the Noanxiety.com resources and the Vanderbilt Rating Scales. Records of pupils' gender, curricular and extra- curricular achievements were taken from the teachers' own class records. Gathered data were suitably tabulated and presented in tables and chart. Both descriptive and inferential statistics were applied to treat the data. Specific tools like percentages, Multiple Linear Regression Analysis, mean and t-test were employed to analyze the collected data. As found out, the Grade 1 pupils' EBD level is singly, and collectively of moderate levels. They have very good level in curricular and extra-curricular achievements alike. Male pupils have relatively higher EBD level than the females. Inversely, the female pupils have comparatively higher achievement than the males. The pupils whose schools were located in highly urbanized places have higher EBD level than those in the less urbanized areas. Also, the achievements of the pupils from schools situated in less urbanized areas were higher than those in the highly urbanized areas. This study concluded that only the pupils' attention deficit hyperactivity disorder was linked to pupils' achievement. Gender and school location also affected pupils' EBD and achievement levels.
Railroad Ballast Fouling Detection Using Ground Penetrating Radar - A New Approach Based on Scattering from Voids

Railroad ballast is the uniformly-graded aggregate between and underneath railroad ties. The purpose of ballast is to provide support for the heavy loading applied by trains. New ballast contains significant void space between the aggregate. As ballast ages it is progressively fouled by fine-grained material that fills the void space. The structural integrity of seriously fouled ballast can be compromised leading to track instability and ultimately, train derailments. For this reason it is very important to be able to detect fouled ballast. Ground penetrating radar (GPR) has been used over the past 25 years for ballast evaluation and has yielded mixed results. Traditionally, GPR data have been interpreted with strategies focusing on reflections from layer interfaces. This can be a severe handicap when obtaining data on a ballast structure which contains gradational fouling. GSSI developed a 2 GHz horn antenna in 2003 which was initially tested on ballast at the Transportation Technology Center, Inc. in Pueblo, CO in 2005 and subsequently on Amtrak Rails near Boston, MA in 2006. It was noted that the antenna is much more focused compared to the commonly used 1 GHz horn antenna and provides data that contain significant scattering energy from the void space in clean ballast. The data from fouled ballast contained minimal scattering from the remaining void space. Comparison of the data obtained using the 2 GHz antenna with available ground truth supports this interpretation. This GPR methodology shows potential for routine inspection of working railroads and is especially suited to assess the ballast fouling condition near the bottom of railroad ties.
Power Control in Multi-Layer Cellular Networks

We investigate the possible performance gains of power control in multi-layer cellular systems where microcells and picocells are distributed within macrocells. Although multilayers in cellular networks help increase system capacity and coverage, and can reduce total energy consumption; they cause interference, reducing the performance of the network. Therefore, downlink transmit power levels of multi-layer hierarchical cellular networks need to be controlled in order to fully exploit their benefits. In this work, we present an analytical derivation to determine optimum power levels for two-layer cellular networks and generalize our solution to multi-layer cellular networks. We also simulate our results in a typical multi-layer network setup and observe significant power savings compared to single-layer cellular networks.
Feature Structures as Weights in Finite State Morphology

We present a finite state morphology system augmented with typed feature structures as weights on transitions. Using a semiring interpretation, the weight of a result represents the possible linguistic interpretations of an input word, while the resulting character string itself represents the lemma of the input. Long-distance phenomena and infixation can be handled in an easy and elegant manner, simultaneously providing a seamless interface to subsequent linguistic processing modules.
Nonlinear oscillations and rotations of a liquid droplet

are simulated numerically by solving the Navier-Stokes equations using the level set method. Mass conservation of droplet is especially taken into consideration for calculations of the level set function. The nonlinear effects of oscillation amplitude and rotation rate on oscillation frequency, which are known as the frequency shift, are shown quantitatively by comparing with theoretical predictions. It is shown for the normalized amplitude and the rotation rate smaller than 0.2 that the simulated frequency shifts are in good agreement with the theoretical predictions and the effects of viscosity and surface tension on the frequency shift are negligibly small.
Can’t stop scrolling!: pathological use of social networking sites in emerging adulthood

Abstract The use of social networking websites (SNS’s) among emerging adults is very common. While evidence suggests that the use of SNS’s can be positive, some research indicates that SNS use may lead to negative outcomes. Research shows that social networking websites have the potential to be used pathologically, and that the pathological use of SNS’s may be associated with negative outcomes. Emerging adulthood has been described as a time to explore independence in a variety of ways. As such, emerging adults may be especially likely to experience pathological SNS use and the associated negative outcomes as they explore many facets of young adult life. The current study examined the mediating role of self-regulation in the associations between pathological SNS use and relational aggression and depression. Participants included 442 emerging adults who were currently registered for social networking websites. Results revealed that self-regulation mediated associations between pathological SNS use and relational aggression and depression, but not the associations between high social media use and the same negative outcomes. The discussion focuses on explanations as to why pathological SNS use is associated with negative outcomes, as mediated by self-regulation, including discussion of upward social comparison, jealousy, and a lack of self-control in online behaviors.
Selection of Lactic Acid Bacteria Isolated from San Simón da Costa Cheese (PDO) in Order to Develop an Autochthonous Starter Culture

Traditional cheeses are an important reservoir of microbial diversity that can have important biotechnological applications, especially with a view to improving the characteristics unique to each type of cheese, and in this respect, starter cultures consisting of autochthonous lactic acid bacteria strains are of particular interest. In the present study, we investigated lactic acid bacteria population diversity in San Simon da Costa cheese (PDO, Galicia, Spain) and found a predominance of the genus Lactobacillus, which by the end of ripening accounted for 78% of the strains isolated in Rogosa agar, around 40% of those in M17 agar and about 10% of those in MSE agar. The main species of lactic acid bacteria identified were Lactococcus lactis subsp. lactis, Lactobacillus casei subsp. casei, Lb. paracasei subsp. paracasei, Leuconostoc mesenteroides and Enterococcus faecalis. Virtually all the strains studied from a technological point of view yielded more than or equal to 0.24 g 100 mL-1 lactic acid. Lactococcus lactis subsp. lactis (SS 194), Lactobacillus paracasei (SS 1695 and SS 1689) and Enterococcus faecalis (SS 1378 and SS 1449) strains exhibited the greatest proteolytic capacity. Based on the overall technological aptitude of the tested strains, we can propose starter cultures and co-cultures that include different combinations of previous strains with a view to manufacturing San Simon da Costa cheese from pasteurised milk.
Adrenomedullin in cultured human retinal pigment epithelial cells.

PURPOSE To determine whether adrenomedullin (ADM), a vasorelaxant peptide is produced and secreted by human retinal pigment epithelial (RPE) cells, whether ADM expression is regulated by inflammatory cytokines and a growth factor, and whether ADM has proliferative effects on these cells. METHODS Production and secretion of ADM by cultured human RPE cells were examined by Northern blot analysis and radioimmunoassay. Regulation of the ADM expression by basic fibroblast growth factor, interferon (IFN)-gamma, tumor necrosis factor-alpha, interleukin (IL)1beta, or all-trans-retinoic acid was studied. In addition, proliferative effects of ADM on human RPE cells were examined by modified 3-(4,5-dimetylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) assay. RESULTS ADM mRNA was expressed constitutively in all three human RPE cell lines (F-0202, D407, and ARPE-19) examined. Immunoreactive ADM was detected in the cultured media by radioimmunoassay. Sephadex G-50 column chromatography of the cultured medium showed a single peak eluting in the position of ADM-(1-52). Treatment with IFN-gamma or IL-beta increased ADM mRNA levels and immunoreactive-ADM levels in the medium in dose- and time-dependent manners in ARPE-19 cells. Exogenously added ADM increased the number of F-0202 cells and ARPE-19 cells, and the treatment with ADM antibody or ADM-(22-52) (an ADM antagonist) decreased it. CONCLUSIONS Human RPE cells produced and secreted ADM. IFN-gamma and IL-1beta induced ADM expression in ARPE-19 cells. Furthermore, ADM stimulated proliferation of RPE cells. These results raise the possibility that ADM is related to the pathophysiology of some inflammatory and proliferative ocular diseases.
Compact Radio Sources in Orion: New Detections, Time Variability, and Objects in OMC-1S

We present the analysis of four 3.6 cm radio continuum archival observations of Orion obtained using the Very Large Array in its A configuration, with 0. ″3 angular resolution. The observations were made during the period 1994–1997. In a region of 4′ × 4′, we detect 77 compact radio sources. Of these sources, 54 are detected in one or more of the individual observations, and 36 of these show time variability (by more than 30%) between the observed epochs. A deep image made from averaging all data shows an additional 23 faint sources, in the range of 0.1 to 0.3 mJy. Of the 77 sources, 39 are new centimeter detections. However, only 9 of the 77 sources do not have a previously reported counterpart at near-infrared, optical, or X-ray wavelengths. In particular, we detect three faint sources in the OMC-1S region that may be related to the sources that power the multiple outflows that emanate from this part of the Orion Nebula.
Genetic variation in aldosterone synthase predicts plasma glucose levels

The mineralocorticoid hormone, aldosterone, is known to play a role in sodium homeostasis. We serendipitously found, however, highly significant association between single-nucleotide polymorphisms in the aldosterone synthase gene and plasma glucose levels in a large population of Chinese and Japanese origin. Two polymorphisms—one in the putative promoter (T-344C) and another resulting in a lysine/arginine substitution at amino acid 173, which are in complete linkage disequilibrium in this population—were associated with fasting plasma glucose levels (P = 0.000017) and those 60 (P = 0.017) and 120 (P = 0.0019) min after an oral glucose challenge. A C/T variant in intron 1, between these polymorphisms, was not associated with glucose levels. Arg-173 and -344C homozygotes were most likely to be diabetic [odds ratio 2.51; 95% confidence interval (C.I.) 1.39–3.92; P = 0.0015] and have impaired fasting glucose levels (odds ratio 3.53; 95% C.I. 2.02–5.5; P = 0.0000036). These results suggest a new role for aldosterone in glucose homeostasis.
The dynamics of the min proteins of Escherichia coli under the constant external fields

In E. coli the determination of the middle of the cell and the proper placement of the septum is essential to the division of the cell. This step depends on the proteins MinC, MinD, and MinE. Exposure to a constant external field e.g., an electric field or magnetic field may cause the bacteria cell division mechanism to change resulting in an abnormal cytokinesis. To have insight into the effects of an external field on this process, we model the process using a set of the deterministic reaction diffusion equations, which incorporate the influence of an external field, min protein reactions, and diffusion of all species. Using the numerical method, we have found some changes in the dynamics of the oscillations of the min proteins from pole to pole when compared that of without the external field. The results show some interesting effects, which are qualitatively in good agreement with some experimental results.
What Can and Can't Crowding Theories Tell Us about Farmers’ ‘Environmental’ Intentions in Post‐Agri‐Environment Scheme Contexts?

6 The termination of the Entry Level Stewardship (ELS) Agri-Environment Scheme in England 7 provides a unique opportunity for testing and exploring the so-called crowding-out theory. The theory 8 posits that payment for the provision of public goods leads to a reduction in the intrinsic motivation 9 for their supply. Through a small qualitative case study of farmers in Southwest England we explore 10 farmers’ intentions to continue with ‘environmental behaviours’ following the cessation of ELS. 11 Contrary to the crowding-out theory we find that farmers will continue with longstanding 12 ‘environmental practices’ that were financially rewarded by the ELS, but will pick and choose 13 whether to continue with newly introduced practices depending on how they fit with farmers’ existing 14 cultural, economic and instrumental priorities. Moreover, we argue that the crowding-out theory is 15 based on a set of assumptions and simplifications that do not adequately help us interpret the 16 relationship between farmers’ motives, practices and intentions. In particular, we show that intrinsic 17 and extrinsic motives cannot straightforwardly be separated and that definitions of what constitutes an 18 ‘environmental behaviour’ are far more complex than is often assumed.
Energetic benefits of enhanced summer roosting habitat for little brown bats (Myotis lucifugus) recovering from white-nose syndrome

Enhancement of summer habitat could improve survival and reproduction by bats recovering from white-nose syndrome (WNS). We found that captive little brown bats (Myotis lucifugus) recovering from WNS preferentially selected heated bat houses and we calculated a dramatic reduction in energy costs for bats in heated roosts.
Robust observer for a class of uncertain linear systems

In this paper a novel framework for robust observer for linear systems with parametric uncertain state matrix is introduced. A new class of high gain observer which incorporates a second gain update output estimation error is developed. With lesser restrictive conditions, it is shown that the conceived high gain observer for a chosen nominal system is insensitive to non-bounded parameters variation and provides good performances. Analytical developments are detailed and adopted choices are justified. Convergence properties for the robust observer are proved through Lyapunov method. Approach validity is illustrated via a detailed numerical example with extensive simulation results.
High-speed focal modulation microscopy using acousto-optical modulators

Focal Modulation Microscopy (FMM) is a single-photon excitation fluorescence microscopy technique which effectively rejects the out-of-focus fluorescence background that arises when imaging deep inside biological tissues. Here, we report on the implementation of FMM in which laser intensity modulation at the focal plane is achieved using acousto-optic modulators (AOM). The modulation speed is greatly enhanced to the MHz range and thus enables real-time image acquisition. The capability of FMM is demonstrated by imaging fluorescence labeled vasculatures in mouse brain as well as self-made tissue phantom.
Static Analysis To Improve Compiler Sanitization

Software security problems in inherently unsafe languages (C/C++) can be addressed by compiler tools that automatically insert checks that trap execution when exploitable faults are encountered at runtime. Such checks are seldom incorporated in production code because of the performance cost they impose, as the check injection to ensure safety is applied indiscriminately to every memory access. Our lab has developed static analysis methods to eliminate runtime checks that can be proven to be unnecessary. The beneﬁt of this is to reduce overhead, improving security of running code at reasonable performance cost. In the current work we present results with benchmark programs that demonstrate the promise of this approach. Using the static analysis frameworks frama-C and CodeSurfer, variables value constraints and code dependency traces are converted to annotations inserted in the source code. Customized LLVM compiler passes incorporate these annotations into variable-attached metadata. During passes that insert runtime security checks, this metadata validates skipping check insertion in instances where the variable value has been proven to be safe. The LLVM compiler “safecode” pass which provides memory safety has so far proved only partially successful; improvements in this pass may manifest in the next iteration of our software. The LLVM compiler “integer overﬂow” pass exhibited excellent improvement in most of the benchmarks tested. In several benchmarks, over 80% of the runtime performance overhead due to these security checks was mitigated by our optimization protocol. Removal os “address sanitization” checks was also generally successful, delivering mitigation of more than 50% of the checks-imposed overhead for several benchmarks. Thesafety checks we studied can eﬀectively elimnate vulnerabilities due to buﬀer overﬂow, integer overﬂow, and use-after-free scenarios. Our protocol greatly enhances the usability of these compiler-generated runtime protections.