Miracle-dz/UniFAR-FTUs huggingface dataset:
Blind identification of source mobile devices using VoIP calls

Sources such as speakers and environments from different communication devices produce signal variations that result in interference generated by different communication devices. Despite these convolutions, signal variations produced by different mobile devices leave intrinsic fingerprints on recorded calls, thus allowing the tracking of the models and brands of engaged mobile devices. This study aims to investigate the use of recorded Voice over Internet Protocol calls in the blind identification of source mobile devices. The proposed scheme employs a combination of entropy and mel-frequency cepstrum coefficients to extract the intrinsic features of mobile devices and analyzes these features with a multi-class support vector machine classifier. The experimental results lead to an accurate identification of 10 source mobile devices with an average accuracy of 99.72%.
An examination of signaling traffic in a super-charged mobile network

Mobility management is the highest contributor of signaling traffic in mobile networks. Messages generated by the insert subscriber data procedure during a location update are not only large but more will be required in future third generation (3G) networks to allow for the transfer of large subscriber profiles. This paper compares the mobility management protocol used in GSM and 3G networks with that proposed for super-charged networks by examining the network's performance under normal conditions and during signaling transfer point congestion.
Distance measurements to radio supernova remnants

We briefly review methods to measure the distances to Galactic radio supernova remnants (SNRs) and objects associated (pulsars and HII regions). We highlight new methods we have developed by giving results from HI and 13CO line spectra of some SNRs. The methods advance traditional methods of HI-absorption-determined-distance to an SNR due to improving background subtraction and spurious emission rejection, and resolving the near/far distance ambiguity in the inner Galaxy. New distances to several SNRs, i.e. W41, G21.5∓0.9, G54.1+0.3, Kes 67, Kes 69, Kes 73 and Kes 75, have been determined.
USAGE OF INFORMATION TECHNOLOGY AND DATA WAREHOUSES IN LARGER SLOVENIAN AND CROATIAN COMPANIES : A COMPARISON

At Faculty of Economics in Ljubljana, Institute for Business Informatics, and at the Faculty of Economics in Zagreb, Department of Business Computing, they have investigated the state of an information system in organizations, the usage of information technology (IT) and a data warehouse concept. The present study was conducted using a questionnaire survey that was given to the IT managers. Questions about Internet technologies and business process reengineering were also included in the research, but that part is not the objective of this paper.
Coal Mine Safety Evaluation with V-Fold Cross-Validation and BP Neural Network

A suit of coal mine safety evaluation indexes have been propounded under the study of current situation about coal mine safety assement. Coal mine safety evaluation system based on BP neural network has been established by employing MATLAB neural network toolbox, and the actual index data will be utilized to validate marking effect through using V-fold Cross-validation technique, and then this will be applied to coal mine safety evaluation system to provide grounds for safety production and management in coal mine.
c-Jun NH2-terminal Kinase Regulation of the Apoptotic Response of Small Cell Lung Cancer Cells to Ultraviolet Radiation*

Exposure of cultured small cell lung cancer (SCLC) cells to UV radiation induces apoptosis. We observed that the UV sensitivity of a panel of SCLC lines and the activation of c-Jun NH2-terminal kinases (JNKs) by UV in the individual SCLC lines, assessed by binding and phosphorylation of glutathione S-transferase (GST)-c-Jun fusion proteins, ranged widely. In fact, increased JNK activity in this assay was closely correlated with decreased sensitivity to apoptosis following UV irradiation. Increased JNK activity was also detected in anti-JNK1 immune complexes collected from UV-irradiated SCLC cells, although the level of activity was similar among the various SCLC lines and correlated poorly with UV sensitivity. Immunoblot analysis of JNK polypeptides that bound to GST-c-Jun revealed at least two JNK polypeptides, one of which appeared only in extracts from UV-irradiated SCLC. To test the role of JNKs in UV-induced apoptosis, nonphosphorylatable mutants of JNK1 or JNK2 in which the phosphorylation site Thr-Pro-Tyr is changed to Ala-Pro-Phe (JNK-APF) and are predicted to behave as competitive inhibitors were stably expressed in SCLC. Expression of JNK1-APF or JNK2-APF significantly reduced UV-stimulated JNK activity. However, JNK1-APF markedly increased the resistance of the cells to UV-induced apoptosis, while JNK2-APF did not influence SCLC sensitivity to UV. The findings suggest that UV-stimulated JNK1 activation promotes UV-induced SCLC apoptosis, while a JNK isoform that is variably activated among the SCLC lines may signal a UV-protective response. We hypothesize that integration of distinct JNK activities dictates the relative responsiveness of SCLC to UV and ionizing radiation.
Efficient Data and Task Co-Scheduling for Scientific Workflow in Geo-Distributed Datacenters

Scientific workflow usually needs to be performed in multiple collaborative datacenters for the requirement of accessing community-wide resources. However, the movements of initial input data and intermediate data across geo-distributed datacenters would hinder efficient execution of large-scale dataintensive scientific workflows. In this paper, a novel scheduling approach based on graph partition is proposed for the execution of data-intensive scientific workflow in geo-distributed datacenters, aiming at the optimization of the overall data transfer cost. Simulations show that our algorithm significantly reduces the overall geo-distributed data transfer and demonstrate its effectiveness.
Retrospective observational study of emergency admission, readmission and the ‘weekend effect’

Objectives Excess mortality following weekend hospital admission has been observed but not explained. As readmissions have greater age, comorbidity and social deprivation, outcomes following emergency index admission and readmission were examined for temporal and demographic associations to confirm whether weekend readmissions contribute towards excess mortality. Design A retrospective observational study. Individual patient Hospital Episode Statistics were linked and 2 categories created: index admissions (not within 60 days of discharge from an emergency hospitalisation) and readmissions (within 60 days of discharge from an emergency hospitalisation). Logistic regression examined associations between admission category, weekend and weekday mortality, age, gender, season, comorbidity and social deprivation. Setting A single acute National Health Service (NHS) trust serving a population of 550 000 via 3 emergency departments. Participants Emergency admissions between 1 January 2010 and 31 March 2015. Outcome measure All-cause 30-day mortality. Results Over 5 years there were 128 966 index admissions (74.7% weekday/25.3% weekend) and 20 030 readmissions (74.9% weekday/25.1% weekend). Adjusted 30-day death rates for weekday/weekend admissions were 6.93%/7.04% for index cases and 12.26%/13.27% for readmissions. Weekend readmissions had a higher mortality risk relative to weekday readmissions (OR 1.10 (95% CI 1.01 to 1.20)) without differences in comorbidity or deprivation. Weekend index admissions did not have a significantly increased mortality risk (OR 1.04 (95% CI 0.98 to 1.11)) but deaths which did occur were associated with lower deprivation (OR 1.24 (95% CI 1.11 to 1.38)) and an absence of comorbidities (OR 1.17 (1.02 to 1.34)). Conclusions Associations with emergency hospitalisation were not identical for index admissions and readmissions. Further research is needed to confirm what factors are responsible for the ‘weekend effect’.
Interactive surgical planning using context based volume visualization techniques

We present a new volume visualization scheme, context based volume visualization to assist the surgeon in surgical planning. This visualization scheme differs from ordinary surface based rendering and volume rendering by providing a framework to combine surface based rendering and volume rendering. We can achieve the powerful manipulating capability of surface based rendering and as good a rendering effect as volume rendering at the same time. Using a special data structured-segment tree to manage the visualization scene, which includes all the volume objects and graphics objects (the surgical tools) needed to be visualized, this visualization scheme provides a common context based interface for both graphics objects and volume objects, through which, we can control graphics and volume objects easily in the same way. The context based visualization scheme can greatly increase the performance of volume visualization by generating the scene much faster through selectively revisualizing the affected objects. Based on these ideas, we implement an interactive surgical planning system, Virtual Doctor based on OpenGL 1.1 on WinNT platform and VolumePro vg500 card. This system is a good 3D volume visualization tool and augmented reality system for interactive surgical planning and further research in this area.
Meta-analysis of DNA double-strand break response kinetics

Abstract Most proteins involved in the DNA double-strand break response (DSBR) accumulate at the damage sites, where they perform functions related to damage signaling, chromatin remodeling and repair. Over the last two decades, studying the accumulation of many DSBR proteins provided information about their functionality and underlying mechanisms of action. However, comparison and systemic interpretation of these data is challenging due to their scattered nature and differing experimental approaches. Here, we extracted, analyzed and compared the available results describing accumulation of 79 DSBR proteins at sites of DNA damage, which can be further explored using Cumulus (http://www.dna-repair.live/cumulus/)—the accompanying interactive online application. Despite large inter-study variability, our analysis revealed that the accumulation of most proteins starts immediately after damage induction, occurs in parallel and peaks within 15–20 min. Various DSBR pathways are characterized by distinct accumulation kinetics with major non-homologous end joining proteins being generally faster than those involved in homologous recombination, and signaling and chromatin remodeling factors accumulating with varying speeds. Our meta-analysis provides, for the first time, comprehensive overview of the temporal organization of the DSBR in mammalian cells and could serve as a reference for future mechanistic studies of this complex process.
The changing structure of a city: temporal changes in cubic spline urban density patterns.

"Using the basic summary of urban structure given by the population density function, this paper estimates changes which have occurred in the structure of the Detroit [Michigan] metropolitan area during the past two decades. Both overall density changes and direction-specific changes are estimated using census data and the method of cubic spline regression. The results give more revealing insight into the structural changes which have occurred in the city than has been possible with traditional models of urban population density. "
Pitch contour from formants for alaryngeal speech

People without a larynx have to communicate with a substitute voice, where all possibilities have major shortcomings. A common problem is the lack of a natural pitch contour. This is either because of a constant pitch in the case of an electro-larynx or very limited control over pitch in case of esophageal or tracheo-esophageal speech. To introduce a more natural pitch contour, we propose to use the speech formants as a source to generate an articial pitch contour. Earlier ofine methods to introduce a natural pitch contour to AL speech have shown, that this signicantly improves the speech quality. For voice modication, we use the voice pulse model which enables us to place voice pulses at arbitrary positions even when no harmonic voice source is available, while preserving the voice identity of the speaker. Informal perceptual evaluations showed that using a formant based fundamental frequency yields a reasonable pitch contour and is perceived as an improvement for alaryngeal speech.
Cross-sectional and longitudinal studies of naturally occurring antibodies to Pseudomonas aeruginosa in cystic fibrosis indicate absence of antibody-mediated protection and decline in opsonic quality after infection.

Most patients with cystic fibrosis (CF) develop chronic endobronchial infection with mucoid Pseudomonas aeruginosa. It has been suggested that opsonic antibodies to the mucoid exopolysaccharide of P. aeruginosa protect older CF patients (> 12 years of age) who have remained free of colonization by this organism. Serum antibodies from chronically infected CF patients had greater total complement-dependent opsonic activity than did those of older noncolonized patients (P < .02), but when bound antibody was equalized, opsonic quality was greater for the latter group (P < .03). In longitudinal studies, antibody titers to mucoid P. aeruginosa rose greatly after initial infection, but opsonic quality declined (P = .002). Twenty CF patients who passed age 12 free of P. aeruginosa colonization developed chronic P. aeruginosa lung infection at ages 14-35 years. Thus, naturally occurring antibodies do not protect CF patients from P. aeruginosa infection, and opsonic quality of serum antibodies deteriorates as infection becomes established.
Human salivary α‐amylase (EC.3.2.1.1) activity and periodic acid and schiff reactive (PAS) staining: A useful tool to study polysaccharides at an undergraduate level

Health science education is presently in discussion throughout Europe due to the Bologna Declaration. Teaching basic sciences such as biochemistry in a health sciences context, namely in allied heath education, can be a challenging task since the students of preclinical health sciences are not often convinced that basic sciences are clinically valuable (J. R. Rudland, S. C. Rennie (2003) The determination of the relevance of basic sciences learning objectives to clinical practice using a questionnaire survey, Med. Educ. (Oxf.) 37, 962–965; E. C. Wragg (2003) How can we determine the relevance of basic sciences learning objectives to clinical practice? , Med. Educ. (Oxf.) 37, 948–949). Thus, nowadays teachers are compelled to use their imagination to be able to elaborate laboratory sessions aiming for the understanding of theoretical concepts that are also clinically related: in other words, basic concepts and skills that underlie the competencies demanded of the future health professional. In the present work, we describe a set of laboratory sessions implemented in the discipline of biochemistry, belonging to the first year of several courses of allied health professionals, which can also be implemented in other health sciences courses. These sessions focus on the characteristics and properties of carbohydrates. The exercises we propose include two different laboratory practical sessions based on a histopathological routine technique known as periodic acid and Schiff reactive that is currently used to detect sugar metabolic and tumor diseases (J. M. T. Rivera, C. T. López, B. C. Segui (2001) Bioquímica Estructural: Conceptos y Tests, Tebar Flores, Madrid). The methodology described enables the demonstration of some biochemical properties of polysaccharides, namely animal and vegetable, and the catalytic activity of the human salivary α‐amylase (EC.3.2.1.1) enzyme. A further comparison between α‐amylase activity in vitro and in situ is also possible by the proposed methodology. Additionally, to this extent, a comparison between the results of the learning improvement that occurred after the implementation of this tool is presented.
Reduction of monocyte‐macrophage activation markers upon anti‐CD4 treatment. Decreased levels of IL‐1, IL‐6, neopterin and soluble CD14 in patients with rheumatoid arthritis

Anti‐CD4MoAbs have been successfully used in initial treatment trials of rheumatoid arthritis. One remarkable feature of this therapy was the early reduction of synovitis along with a decrease of the erythrocyte sedimentation rate (ESR) and the C‐reactive protein (CRP). Since not only T helper celis. but also monocytes‐maerophages bear the CD4 antigen, the question was raised whether the immediate elTects observed may have been in part due to an influence on the mononuclear phagocyte system. Inimediately after MoAb infusions, a significant reduction of the absolute peripheral blood monocyte count down to 30%(P < 0·001) was noted within the firsl hour of injection. In contrast to strikingly elevated levels of soluble CD4 after treatment which was indicative of T cell lysis, soluble CD14 levels did not rise, but rather decreased from previously elevated levels. Before treatment, aetivation of the monocyte‐macrophage system had been signified by elevated serum levels of IL‐1, IL‐6. CRP and neopterin as well as a marked in vitro production of IL‐1. tumour necrosis faetor‐alpha (TNF‐α)and IL‐6. Subsequent anti‐CD4 treatment resulted in a rapid and significant reduction of monocyte‐derived circulating cytokines and mediators concordant with a reduced capacity to produce IL‐1. TNF‐α, and IL‐6 in those paiients who demonstrated clinical benefits. Therefore, studies of monocyte aetivation markers may be useful in identifying subsequent responders to anti‐CD4 therapy.
Functional and clinical significance of skeletal muscle architecture

Skeletal muscle architecture is the structural property of whole muscles that dominates their function. This review describes the basic architectural properties of human upper and lower extremity muscles. The designs of various muscle groups in humans and other species are analyzed from the point of view of optimizing function. Muscle fiber arrangement and motor unit arrangement is discussed in terms of the control of movement. Finally, the ability of muscles to change their architecture in response to immobilization, eccentric exercise, and surgical tendon transfer is reviewed. Future integrative physiological studies will provide insights into the mechanisms by which such adaptations occur. It is likely that muscle fibers transduce both stress and strain and respond by modifying sarcomere number in a way more suited to the new biomechanical environment. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 1647–1666, 2000
Studies on the structure and stabilizing factor of the CUUCGG hairpin RNA using chemically synthesized oligonucleotides

A tridecaribonucleotide, r-UGAGCUUCGGCUC, and two analogues r(UGAGC)d(UUCG)r(GCUC) and r-UGAGCUUCIGCUC, which form a hairpin structure with a four-base-paired stem and a UUCG loop, were synthesized by the solid-phase phosphoramidite method. Properties of these three oligomers and d-TGAGCTTCGGCTC, the DNA analogue, were studied by UV, CD and NMR spectroscopy. The melting temperature (Tm) data suggest that the 2'-hydroxy1 groups and the 2-amino group of guanosine in the loop (9G) stabilize the CUUCGG hairpin which is known to have an unusually high Tm. NMR studies show that this 9G takes a syn conformation and the phosphodiester backbone has a turn at 9G-10G which is a junction of the stem and loop.
Selective biochemical modification of functional residues in recombinant human macrophage colony-stimulating factor beta (rhM-CSF beta): identification by mass spectrometry.

A rapid method combining classical chemical modification with mass spectrometry was developed to identify amino acids in the recombinant human macrophage colony-stimulating factor (rhM-CSF) protein of potential import to the ligand-receptor interaction. Diethyl pyrocarbonate modification of rhM-CSF beta (under nondenaturing conditions) results in a time- and concentration-dependent loss in receptor binding and biological activity. Peptide mapping of the reaction products by mass spectrometry showed that, with low DEP:M-CSF ratios (< 50:1), there was selective modification of histidine residues, whereas at higher ratios (> 50:1), Tyr and Lys residues were also modified. The loss in rhM-CSF beta activity was directly correlated with the extent of carbethoxylation of His9 and His15, as determined by matrix-assisted laser desorption/ionization mass spectrometric molecular weight determinations (MALDIMS). For these residues mono-modification was observed. By contrast, C-terminal histidine residues His176 and His210 showed bis-modifications, the extent of which had no correlation to losses in biological activity. These data suggest the importance of residues in the A-helix (His9 and His15) to ligand-receptor binding.
Creating cat states in one-dimensional quantum walks using delocalized initial states

Cat states are coherent quantum superpositions of macroscopically distinct states and are useful for understanding the boundary between the classical and the quantum world. Due to their macroscopic nature, cat states are difficult to prepare in physical systems. We propose a method to create cat states in one-dimensional quantum walks using delocalized initial states of the walker. Since the quantum walks can be performed on any quantum system, our proposal enables a platform-independent realization of the cat states. We further show that the linear dispersion relation of the effective quantum walk Hamiltonian, which governs the dynamics of the delocalized states, is responsible for the formation of the cat states. We analyze the robustness of these states against environmental interactions and present methods to control and manipulate the cat states in the photonic implementation of quantum walks.
Organization of the regulatory region of the yeast CYC7 gene: multiple factors are involved in regulation

Regulation of the CYC7 gene of Saccharomyces cerevisiae, encoding iso-2-cytochrome c, was studied. Expression was induced about 20-fold by heme and derepressed 4- to 8-fold by a shift from glucose medium to one containing a nonfermentable carbon source. Deletion analysis showed that induction by heme depends upon sequences between -250 and -228 (from the coding sequence) and upon the HAP1 activator gene, previously shown to be required for CYC1 expression (L. Guarente et al., Cell 36:503-511, 1984). Thus, HAP1 coordinates expression of CYC7 and CYC1, the two genes encoding isologs of cytochrome c in S. cerevisiae. HAP1-18, a mutant allele of HAP1, which increased CYC7 expression more than 10-fold, also acted through sequences between -250 and -228. In vitro binding studies showed that the HAP1 product binds to these sequences (see also K. Pfeifer, T. Prezant, and L. Guarente, Cell 49:19-28, 1987) and an additional factor binds to distal sequences that lie between -201 and -165. This latter site augmented CYC7 expression in vivo. Derepression of CYC7 expression in a medium containing nonfermentable carbon sources depended upon sequences between -354 and -295. The interplay of these multiple sites and the factors that bind to them are discussed.