Miracle-dz/UniFAR-FTUs huggingface dataset:
The Criminal Justice Experience of African American Cocaine Users in Arkansas

ABSTRACT Background: African Americans are incarcerated at rates much higher than other racial and ethnic groups in the United States. Objectives: We sought to qualitatively explore the relationships between ongoing involvement in the criminal justice system and continued drug use in a population of urban and rural African American cocaine users in a southern state. Methods: Semi-structured qualitative interviews were conducted among African American cocaine users in Arkansas between 2010 and 2012. Participants resided in both rural (two counties located in the eastern Arkansas Mississippi delta region) and urban (the county including the capital city of Little Rock) areas. Results: Numerous important themes emerged from participants’ narratives, including chronic involvement with the criminal justice system (being a “career criminal”), continued access to drugs while incarcerated, relapse, and reincarceration and lack of access to effective drug treatment. Conclusion/Importance: The themes which emerged from our data speak to the collective experience that many substance using populations in the United States face in dealing with the criminal justice system. Our findings highlight the need to better, more holistic ways of engaging African American substance users in community based substance use treatment and supportive services.
PAQR4 has a tumorigenic effect in human breast cancers in association with reduced CDK4 degradation

Progestin and adipoQ receptor 4 (PAQR4) is a member of the PAQR family, and the members within this family are involved in the regulation of a number of biological processes including metabolism and cancer development. The potential function of PAQR4 in human cancers is unknown. Analysis of ONCOMINE database reveals that PAQR4 is highly expressed in human breast cancers. We confirmed this finding by analyzing 82 human breast cancers samples. PAQR4 mRNA level was significantly upregulated in human breast cancer samples compared with their corresponding para-cancerous histological normal tissues (P < 0.0001). The mRNA level of PAQR4 was negatively correlated with disease-free survival (P < 0.0001) and overall survival of the patients (P = 0.001). Knockdown of PAQR4 in human breast cancer cells SUM159 and MCF7 suppressed cell proliferation. In contrast, overexpression of PAQR4 in SUM159 cells enhanced cell proliferation and colony formation. In a tumor xenograft model, overexpression of PAQR4 promoted tumor growth of SUM159 cells in vivo, while PAQR4 knockdown suppressed the tumor growth. PAQR4 was able to negatively regulate cyclin-dependent kinases 4 (CDK4) protein level in the breast cancer cells. Knockdown of PAQR4 accelerated degradation of CDK4 together with upregulation of CDK4 polyubiquitination. On the other hand, overexpression of PAQR4 slowed down CDK4 protein degradation and reduced CDK4 polyubiquitination. Collectively, these data at the cellular, animal and human levels indicate that PAQR4 has a tumorigenic effect on human breast cancers, and such effect is associated with a modulatory activity of PAQR4 on protein degradation of CDK4.
Overweight and Obesity Among Primary School Children in Misurata City-Libya: Prevalence and Associated Risk Factors

The prevalence of obesity is increasing worldwide at an alarming rate in both developed and developing countries [1]. The current lack of consistency and agreement among different studies in the classification of overweight and obesity in children and adolescents makes it difficult to give an overview of the global prevalence of overweight and obesity in young age groups. Nevertheless, irrespective of the classification system used, most studies of overweight and obesity during childhood and adolescence have reported that the prevalence of both has increased.
Swimming pool exposure is associated with autonomic changes and increased airway reactivity to a beta-2 agonist in school aged children: A cross-sectional survey

Background Endurance swimming exercises coupled to disinfection by-products exposure has been associated with increased airways dysfunction and neurogenic inflammation in elite swimmers. However, the impact of swimming pool exposure at a recreational level on autonomic activity has never been explored. Therefore, this study aimed to investigate how swimming pool attendance is influencing lung and autonomic function in school-aged children. Methods A total of 858 children enrolled a cross sectional survey. Spirometry and airway reversibility to beta-2 agonist, skin-prick-tests and exhaled nitric oxide measurements were performed. Pupillometry was used to evaluate autonomic nervous function. Children were classified as current swimmers (CS), past swimmers (PS) and non-swimmers (NS), according to the amount of swimming practice. Results Current swimmers group had significantly lower maximum and average pupil constriction velocities when compared to both PS and NS groups (3.8 and 5.1 vs 3.9 and 5.3 vs 4.0 and 5.4 mm/s, p = 0.03 and p = 0.01, respectively). Moreover, affinity to the beta-2 agonist and levels of exhaled nitric oxide were significantly higher in CS when compared to NS (70 vs 60 mL and 12 vs 10 ppb, p<0.01 and p = 0.03, respectively). A non-significant trend for a higher risk of asthma, atopic eczema and allergic rhinitis was found with more years of swimming practice, particularly in atopic individuals (β = 1.12, 1.40 and 1.31, respectively). After case-case analysis, it was possible to observe that results were not influenced by the inclusion of individuals with asthma. Conclusions Concluding, swimming pool attendance appears to be associated with autonomic changes and increased baseline airway smooth muscle constriction even in children without asthma.
Multimodal Image Super-Resolution via Joint Sparse Representations Induced by Coupled Dictionaries

Real-world data processing problems often involve various image modalities associated with a certain scene, including RGB images, infrared images, or multispectral images. The fact that different image modalities often share certain attributes, such as edges, textures, and other structure primitives, represents an opportunity to enhance various image processing tasks. This paper proposes a new approach to construct a high-resolution (HR) version of a low-resolution (LR) image, given another HR image modality as guidance, based on joint sparse representations induced by coupled dictionaries. The proposed approach captures complex dependency correlations, including similarities and disparities, between different image modalities in a learned sparse feature domain in lieu of the original image domain. It consists of two phases: coupled dictionary learning phase and coupled super-resolution phase. The learning phase learns a set of dictionaries from the training dataset to couple different image modalities together in the sparse feature domain. In turn, the super-resolution phase leverages such dictionaries to construct an HR version of the LR target image with another related image modality for guidance. In the advanced version of our approach, multistage strategy and neighbourhood regression concept are introduced to further improve the model capacity and performance. Extensive guided image super-resolution experiments on real multimodal images demonstrate that the proposed approach admits distinctive advantages with respect to the state-of-the-art approaches, for example, overcoming the texture copying artifacts commonly resulting from inconsistency between the guidance and target images. Of particular relevance, the proposed model demonstrates much better robustness than competing deep models in a range of noisy scenarios.
A Comparative Study of IT Outsourcing Management in Australia and Taiwan

Growth in IT outsourcing is expected to remain high in the coming years as there have been widespread market claims that IT outsourcing can re duce firms’ costs by over 30 percent. The scope and range of IT outsourcing services are also increasin g, as evidenced by the promotion of ASP (applicatio ns service providers), global outsourcing, software de velopment outsourcing, and web and e-business outsourcing. However, management of IT outsourcing evaluation is particularly under-studied, especiall y in how these firms measure their IT outsourcing con tracts and ensure that benefits expected from these contracts are delivered. The main objective of this paper is to examine and compare the current management practices in IT outsourcing evaluation a nd benefits realization by Australian and Taiwanese firms. The paper first reviews relevant literature with respect to IT outsourcing, the evaluation of I T outsourcing, and IT benefits realization. Key surve y findings from the Australian and Taiwanese firms will be presented.
Access to scientific information. A national survey of the Italian Society of Clinical Biochemistry and Laboratory Medicine (SIBioC)

Abstract Background: Digital libraries are typically used for retrieving and accessing articles in academic journals and repositories. Previous studies have been published about the performance of various biomedical research platforms, but no information is available about access preferences. Methods: A six-question survey was designed by the Italian Society of Clinical Biochemistry and Laboratory Medicine (SIBioC) using the platform Google Drive, and made available for 1 month to the members of the society. The information about the survey was published on the website of SIBioC and also disseminated by two sequential newsletters. Results: Overall, 165 replies were collected throughout the 1-month survey availability. The largest number of replies were provided by laboratory professionals working in the national healthcare system (44.2%), followed by those working in private facilities (13.9%), university professors (12.7%) and specialization training staff (12.7%). The majority of responders published zero to one articles per year (55.2%), followed by two to five articles per year (37.6%), whereas only 7.3% published more than five articles per year. A total of 34.5% of the responders consulted biomedical research platforms on weekly basis, followed by 33.9% who did so on daily basis. PubMed/Medline was the most accessed scientific database, followed by Scopus, ISI Web of Science and Google Scholar. The impact factor was the leading reason when selecting which journal to publish in. The most consulted journals in the field of laboratory medicine were Clinical Chemistry and Laboratory Medicine and Biochimica Clinica. Conclusions: This survey provides useful indications about the personal inclination towards access to scientific information in our country.
Accurate differential tanh(nx) implementation

This paper presents a novel non‐linear neural activation function architecture that approximates the tanh(nx) function accurately. The purpose of this realization is the description of a circuit that can be designed to obtain different slopes at the origin of the activation function. The special features of transistors working in the subthreshold region are combined with current mode techniques in order to minimize power consumption and occupied area. Moreover, the circuit has been designed with fully differential and balanced topologies so that the external influences, offset, and distortion of even order are reduced. The proposed activation function is thoroughly explained and it is analysed taking the body effect into account. Some modifications are applied in order to immunize it from the body effect, and simulated results for an implementation on a 0.35 µm AMI technology are presented. Copyright © 2008 John Wiley & Sons, Ltd.
Medical society engagement in contentious policy reform: the Ethiopian Society for Obstetricians and Gynecologists (ESOG) and Ethiopia’s 2005 reform of its Penal Code on abortion

Abstract Unsafe abortion is one of the three leading causes of maternal mortality in low-income countries; however, few countries have reformed their laws to permit safer, legal abortion, and professional medical associations have not tended to spearhead this type of reform. Support from a professional association typically carries more weight than does that from an individual medical professional. However, theory predicts and the empirical record largely reveals that medical associations shy from engagement in conflictual policymaking such as on abortion, except when professional autonomy or income is at stake. Using interviews with 10 obstetrician–gynaecologists and 44 other leaders familiar with Ethiopia’s reproductive health policy context, as well as other primary and secondary sources, this research examines why, counter to theoretical expectations from the sociology of medical professions literature and experience elsewhere, the Ethiopian Society of Obstetricians & Gynecologists (ESOG) actively supported reform of national law on abortion. ESOG leadership participation was motivated by both individual and ESOG’s organizational commitments to reducing maternal mortality and also by professional training and work experience. Further, typical constraints on medical society involvement in policymaking were relaxed or removed, including those related to ESOG’s organizational structure and history, and to political environment. Findings do not contradict theory positing medical society avoidance of socially conflictual health policymaking, but rather identify how the expected restrictions were less present in Ethiopia, facilitating medical society participation. Results can inform efforts to encourage medical society participation in policy reform to improve women’s health elsewhere in sub-Saharan Africa.
Long non-coding RNA: Functional agent for disease traits

ABSTRACT In recent years, long non-coding RNAs (lncRNAs) have attracted the attention of researchers with their involvement in all facets of life. LncRNAs are transcripts of more than 200 nucleotides which lack defined protein coding potential. Although they do not code for proteins, a large number of them are involved in regulating gene expression and translation. The presence of numerous lncRNAs in the human genome has prompted us to investigate the contribution of these molecules to human biology and medicine. In this review, we present the potential role of lncRNAs interlinked to different human diseases and genetic disorders. We also describe their role in cellular differentiation and aging and discuss their potential importance as biomarkers and as therapeutic agents.
Optimal Ensemble Control of Loads in Distribution Grids with Network Constraints

Flexible loads, e.g. thermostatically controlled loads (TCLs), are technically feasible to participate in demand response (DR) programs. On the other hand, there is a number of challenges that need to be resolved before it can be implemented in practice en masse. First, individual TCLs must be aggregated and operated in sync to scale DR benefits. Second, the uncertainty of TCLs needs to be accounted for. Third, exercising the flexibility of TCLs needs to be coordinated with distribution system operations to avoid unnecessary power losses and compliance with power flow and voltage limits. This paper addresses these challenges. We propose a network-constrained, open-loop, stochastic optimal control formulation. The first part of this formulation represents ensembles of collocated TCLs modelled by an aggregated Markov Process (MP), where each MP state is associated with a given power consumption or production level. The second part extends MPs to a multi-period distribution power flow optimization. In this optimization, the control of TCL ensembles is regulated by transition probability matrices and physically enabled by local active and reactive power controls at TCL locations. The optimization is solved with a Spatio-Temporal Dual Decomposition (ST-D2) algorithm. The performance of the proposed formulation and algorithm is demonstrated on the IEEE 33-bus distribution model.
Analyzing the Composition of the Female Workforce - A Semiparametric Copula Approach

We provide a semiparametric copula approach for estimating a "classical" sample selection model. We impose that the joint distribution function of unobservables can be characterized by a specifc copula, but the marginal distribution functions are estimated semiparametrically. In contrast to existing semiparametric estimators for sample selection models, our approach provides a measure of dependence between unobservables in main and selection equation which can be used to analyze the composition of, say, the female workforce. We apply our estimation procedure to a female labor supply data set and show that those women with the best skills participate in the labor market; moreover, we find evidence for the existence of an ability threshold which involves that women with high ability are to some extent advantaged and, therefore, have also obtained the best skills.
Size-Frequency Distributions along a Latitudinal Gradient in Middle Permian Fusulinoideans

Geographic gradients in body size within and among living species are commonly used to identify controls on the long-term evolution of organism size. However, the persistence of these gradients over evolutionary time remains largely unknown because ancient biogeographic variation in organism size is poorly documented. Middle Permian fusulinoidean foraminifera are ideal for investigating the temporal persistence of geographic gradients in organism size because they were diverse and abundant along a broad range of paleo-latitudes during this interval (∼275–260 million years ago). In this study, we determined the sizes of Middle Permian fusulinoidean fossils from three different paleo-latitudinal zones in order to examine the relationship between the size of foraminifers and regional environment. We recovered the following results: keriothecal fusulinoideans are substantially larger than nonkeriothecal fusulinoideans; fusulinoideans from the equatorial zone are typically larger than those from the north and south transitional zones; neoschwagerinid specimens within a single species are generally larger in the equatorial zone than those in both transitional zones; and the nonkeriothecal fusulinoideans Staffellidae and Schubertellidae have smaller size in the north transitional zone. Fusulinoidean foraminifers differ from most other marine taxa in exhibiting larger sizes closer to the equator, contrary to Bergmann's rule. Meridional variation in seasonality, water temperature, nutrient availability, and carbonate saturation level are all likely to have favored or enabled larger sizes in equatorial regions. Temporal variation in atmospheric oxygen concentrations have been shown to account for temporal variation in fusulinoidean size during Carboniferous and Permian time, but oxygen availability appears unlikely to explain biogeographic variation in fusulinoidean sizes, because dissolved oxygen concentrations in seawater typically increase away from the equator due to declining seawater temperatures. Consequently, our findings highlight the fact that spatial gradients in organism size are not always controlled by the same factors that govern temporal trends within the same clade.
Gravitational Shear, Flexion, and Strong Lensing in Abell 1689

We present a gravitational lensing analysis of the galaxy cluster Abell 1689, incorporating measurements of the weak shear, flexion, and strong lensing induced in background galaxies. This is the first time that a shapelet technique has been used to reconstruct the distribution of mass in this cluster and the first time that a flexion signal has been measured using cluster members as lenses. From weak shear measurements alone, we generate a nonparametric mass reconstruction, which shows significant substructure corresponding to groups of galaxies within the cluster. In addition, our galaxy-galaxy flexion signal demonstrates that the cluster galaxies can be well fit by a singular isothermal sphere model with a characteristic velocity dispersion of σv = (295 ± 40) km s-1. We identify a major, distinct dark matter clump, offset by 40 h-1 kpc from the central cluster members, which was not apparent from shear measurements alone. This secondary clump is present in a parametric mass reconstruction using flexion data alone, and its existence is suggested in a nonparametric reconstruction of the cluster using a combination of strong and weak lensing. As found in previous studies, the mass profile obtained by combining weak and strong lensing data shows a much steeper profile than that obtained from only weak lensing data.
Large-Scale Turnover of Functional Transcription Factor Binding Sites in Drosophila

The gain and loss of functional transcription factor binding sites has been proposed as a major source of evolutionary change in cis-regulatory DNA and gene expression. We have developed an evolutionary model to study binding-site turnover that uses multiple sequence alignments to assess the evolutionary constraint on individual binding sites, and to map gain and loss events along a phylogenetic tree. We apply this model to study the evolutionary dynamics of binding sites of the Drosophila melanogaster transcription factor Zeste, using genome-wide in vivo (ChIP–chip) binding data to identify functional Zeste binding sites, and the genome sequences of D. melanogaster, D. simulans, D. erecta, and D. yakuba to study their evolution. We estimate that more than 5% of functional Zeste binding sites in D. melanogaster were gained along the D. melanogaster lineage or lost along one of the other lineages. We find that Zeste-bound regions have a reduced rate of binding-site loss and an increased rate of binding-site gain relative to flanking sequences. Finally, we show that binding-site gains and losses are asymmetrically distributed with respect to D. melanogaster, consistent with lineage-specific acquisition and loss of Zeste-responsive regulatory elements.
A Role for Glutamate Transporters in the Regulation of Insulin Secretion

In the brain, glutamate is an extracellular transmitter that mediates cell-to-cell communication. Prior to synaptic release it is pumped into vesicles by vesicular glutamate transporters (VGLUTs). To inactivate glutamate receptor responses after release, glutamate is taken up into glial cells or neurons by excitatory amino acid transporters (EAATs). In the pancreatic islets of Langerhans, glutamate is proposed to act as an intracellular messenger, regulating insulin secretion from β-cells, but the mechanisms involved are unknown. By immunogold cytochemistry we show that insulin containing secretory granules express VGLUT3. Despite the fact that they have a VGLUT, the levels of glutamate in these granules are low, indicating the presence of a protein that can transport glutamate out of the granules. Surprisingly, in β-cells the glutamate transporter EAAT2 is located, not in the plasma membrane as it is in brain cells, but exclusively in insulin-containing secretory granules, together with VGLUT3. In EAAT2 knock out mice, the content of glutamate in secretory granules is higher than in wild type mice. These data imply a glutamate cycle in which glutamate is carried into the granules by VGLUT3 and carried out by EAAT2. Perturbing this cycle by knocking down EAAT2 expression with a small interfering RNA, or by over-expressing EAAT2 or a VGLUT in insulin granules, significantly reduced the rate of granule exocytosis. Simulations of granule energetics suggest that VGLUT3 and EAAT2 may regulate the pH and membrane potential of the granules and thereby regulate insulin secretion. These data suggest that insulin secretion from β-cells is modulated by the flux of glutamate through the secretory granules.