Miracle-dz/UniFAR-FTUs huggingface dataset:
Ensemble of model-based and data-driven prognostic approaches for reliability prediction

Accurate prediction of system reliability is of plenty of importance to engineering systems for accomplishing the designate function and system safety management. As the concerned system is getting complicated and more sufficient health monitoring measurement is available, the traditional reliability prediction schemes resorting to only one kind of prediction approaches, model-based or data-driven, begin to show their limitations. This paper proposes an ensemble prognostic method by combining traditional model-based with data-driven approaches. Initially, two member algorithms for state-of-health (SOH) prediction are weighted-sum by utilizing the historical prediction error. Then, to compare the performance of our ensemble prediction with the model-based, data-driven, kalman filter and hybrid approaches, experiments based on electrolytic capacitor capacitance degradation and lithium-ion battery capacity degradation are performed. Finally, by employing the available data as well as dynamically adjusting weights, smaller prediction error and standard deviation are derived. Based on the aforementioned analysis, the better prediction performance of the proposed method has been verified.
Mobile Robot's Map Reconstruction Based on DSmT and Fast-Hough Self-Localization

This paper presents a new tool based on DSmT (Dezert-Smarandache Theory) and fast-Hough self-localization which is applied to autonomous mobile robot's map reconstruction. Uncertainty from sonar information is fused and managed in rebuilding grid map effectively with DSmT, since fast-Hough self-localization from laser information overcomes some shortcomings of classical Hough transformation including high amount of computation and low precision of localization. When a virtual mobile robot evolves in the virtual environment with different outline features, the result can adequately testify that the new tool owns better performance to rebuild map. In general, this research provides an approach for studying autonomous navigation of mobile robot or unmanned land vehicle (ULV) in unknown environment, also provides a human- computer interactive interface to manage and manipulate the robot remotely.
Update of NUREBASE: nuclear hormone receptor functional genomics

Nuclear hormone receptors are an abundant class of ligand-activated transcriptional regulators, found in varying numbers in all animals. Based on our experience of managing the official nomenclature of nuclear receptors, we have developed NUREBASE, a database containing protein and DNA sequences, reviewed protein alignments and phylogenies, taxonomy and annotations for all nuclear receptors. New developments in NUREBASE include explicit declaration of alternative transcripts of each gene, and expression data for human and mouse nuclear receptors. The core of NUREBASE is reviewed, and it is completed by NUREBASE_DAILY, automatically updated every 24 h. All information on accessing and installing NUREBASE may be found at http://www. ens-lyon.fr/LBMC/laudet/nurebase/nurebase.html.
Complete Genome Sequence of the Broad-Host-Range Vibriophage KVP40: Comparative Genomics of a T4-Related Bacteriophage

ABSTRACT The complete genome sequence of the T4-like, broad-host-range vibriophage KVP40 has been determined. The genome sequence is 244,835 bp, with an overall G+C content of 42.6%. It encodes 386 putative protein-encoding open reading frames (CDSs), 30 tRNAs, 33 T4-like late promoters, and 57 potential rho-independent terminators. Overall, 92.1% of the KVP40 genome is coding, with an average CDS size of 587 bp. While 65% of the CDSs were unique to KVP40 and had no known function, the genome sequence and organization show specific regions of extensive conservation with phage T4. At least 99 KVP40 CDSs have homologs in the T4 genome (Blast alignments of 45 to 68% amino acid similarity). The shared CDSs represent 36% of all T4 CDSs but only 26% of those from KVP40. There is extensive representation of the DNA replication, recombination, and repair enzymes as well as the viral capsid and tail structural genes. KVP40 lacks several T4 enzymes involved in host DNA degradation, appears not to synthesize the modified cytosine (hydroxymethyl glucose) present in T-even phages, and lacks group I introns. KVP40 likely utilizes the T4-type sigma-55 late transcription apparatus, but features of early- or middle-mode transcription were not identified. There are 26 CDSs that have no viral homolog, and many did not necessarily originate from Vibrio spp. , suggesting an even broader host range for KVP40. From these latter CDSs, an NAD salvage pathway was inferred that appears to be unique among bacteriophages. Features of the KVP40 genome that distinguish it from T4 are presented, as well as those, such as the replication and virion gene clusters, that are substantially conserved.
Neoconstructivism: The New Science of Cognitive Development

Arguments over the developmental origins of human knowledge are ancient, founded in the writings of Plato, Aristotle, Descartes, Hume, and Kant. They have also persisted long enough to become a core area of inquiry in cognitive and developmental science. Empirical contributions to these debates, however, appeared only in the last century, when Jean Piaget offered the first viable theory of knowledge acquisition that centered on the great themes discussed by Kant: object, space, time, and causality. The essence of Piaget's theory is constructivism: The building of concepts from simpler perceptual and cognitive precursors, in particular from experience gained through manual behaviors and observation. The constructivist view was disputed by a generation of researchers dedicated to the idea of the "competent infant," endowed with knowledge (say, of permanent objects) that emerged prior to facile manual behaviors. Taking this possibility further, it has been proposed that many fundamental cognitive mechanisms - reasoning, event prediction, decision-making, hypothesis testing, and deduction - operate independently of all experience, and are, in this sense, innate. The competent-infant view has an intuitive appeal, attested to by its widespread popularity, and it enjoys a kind of parsimony: It avoids the supposed philosophical pitfall posed by having to account for novel forms of knowledge in inductive learners. But this view leaves unaddressed a vital challenge: to understand the mechanisms by which new knowledge arises. This challenge has now been met. The neoconstructivist approach is rooted in Piaget's constructivist emphasis on developmental mechanisms, yet also reflects modern advances in our understanding of learning mechanisms, cortical development, and modeling. This book brings together, for the first time, theoretical views that embrace computational models and developmental neurobiology, and emphasize the interplay of time, experience, and cortical architecture to explain emergent knowledge, with an empirical line of research identifying a set of general-purpose sensory, perceptual, and learning mechanisms that guide knowledge acquisition across different domains and through development.
Novel design of a 10 dB back-off broadband sequential Doherty power amplifier for wireless applications

This paper presents the design and experimental results of a broadband sequential Doherty power amplifier (S-DPA). This new type of DPA allows large back-off (BO), highly efficient and broadband DPAs to be realised. A 10 W/10 dB BO S-DPA is designed to verify the design concept. Measurement results show obvious Doherty behaviour with 8 - 11 dB output power back-off over a 1.85 - 2.4 GHz frequency range. A drain efficiency of 65% over 300 MHz at BO and ≥ 58% over 500 MHz bandwidth at saturation is obtained. To show the state-of-the-art of the S-DPA, the drain efficiency at 2.0 GHz is selected with 74.5 % at saturation and 67.3% at 10 dB BO. Linearised measurement with a 10 MHz LTE signal having a crest factor of 7.5 dB at 2.1 GHz exhibits an average drain efficiency of 53% and an adjacent channel leakage ratio (ACLR) of -44.2/ - 48.7 dBc at an average output power of 32.7 dBm. To the best of the author's knowledge, this is the first wideband, 10 dB BO DPA with such high efficiency reported so far.
Free-Running Rhythms of Pineal Circadian Output

Circadian rhythms are self-sustaining oscillations that free-run in constant conditions with a period close to 24 h. Overt circadian rhythms have been studied mostly using onset phase as the marker for the underlying pacemaker. Using in vivo online pineal microdialysis, the authors have performed detailed analysis of free-running profiles of rat pineal secretory products, including N-acetylserotonin (NAS) and melatonin that have precisely defined onsets and offsets. When rats entrained in LD 12:12 were released into constant darkness (DD), both onset and offset phases of melatonin and NAS free-run. However, while onsets free-run with a period closer to a day (FRPon = 24-24.17 h) at the beginning, offset phases free-run with significantly larger FRPs (free-running periods) (FRPoff = 24.24-24.42 h). This asymmetric free-running of onset and offset of NAS and melatonin in DD resulted in a 60- to 120-min increase of secretion duration of both NAS and melatonin. The rate of expansion of melatonin duration was 10 to 15 min per circadian cycle. The expansion of melatonin secretion duration ended for some within 4 days, while others were still expanding by the end of 10th day in DD. These results revealed that upon release into DD, the pacemaker’s oscillation is initially driven by 2 forces, free running and decompression, before reaching a stable state of free running, and suggest that the circadian pacemaker may be an elastic structure that can decompress and compress under varying photic conditions. They also illustrate the importance of using both onset and offset of a given rhythm as phase markers, as compression/decompression, and transient disparity between FRPon and FRPoff may be a common phenomenon of the circadian pacemaker.
Adherence influences monocyte responsiveness to interleukin‐10

We studied the effects of adherence on the properties of interleukin (IL)‐10 on monocyte‐enriched peripheral blood mononuclear cells. We found that the decrease of CD11b expression induced by IL‐10 was enhanced by adherence. Toll‐like receptor (TLR)2 and TLR4 mRNA, as well as TLR4 surface expression, were significantly up‐regulated by IL‐10 in adherent cells. The absence of adherence prevented the inhibitory effects of IL‐10 on lipopolysaccharide‐induced tumor necrosis factor (TNF) and granulocyte‐colony stimulating factor production and increased IL‐1β production and soluble TNF receptor II release in IL‐10‐pretreated cells. Similarly, the absence of adherence amplified the enhancement of phagocytosis induced by IL‐10. Tyk2 and signal transducer and activator of transcription 3 (STAT3) phosphorylation and suppressr of cytokine signaling 3 (SOCS3) expression were induced by IL‐10 in both conditions, but a longer activation and/or expression were observed in adherent monocytes. Finally, heme oxygenase‐1, an anti‐inflammatory molecule, was induced by IL‐10 in adherent monocytes, whereas its expression remained low in nonadherent cells. Altogether, these data illustrate that adherence modulates the properties and the anti‐inflammatory effects of IL‐10.
HETRIS: Adaptive floorplanning for heterogeneous FPGAs

Floorplanning is an approach to improve the scalability of existing CAD algorithms, facilitate team-based design, and also plays an important role in partial reconfiguration. This work introduces HETRIS, a new automated floorplanning tool for heterogeneous FPGAs. HETRIS uses an adaptive legality approach to target arbitrary FPGA architectures. It includes enhancements enabling it to run on average 15.6× faster than previous work, while producing denser floorplans than a commercial tool. Using HETRIS we perform the first evaluation of an FPGA floorplanner using real-world benchmarks, allowing us to investigate the relationship between partitioning, floorplanning and FPGA architecture.
Advances in pediatric cardiac MRI

Purpose of review Spurred by numerous recent technological advances, cardiac MRI (CMR) is now the gold standard for anatomic evaluation, quantitative assessment of chamber size and function, flow quantification, and tissue characterization. This review focuses on recent advances in pediatric and congenital CMR, highlighting recent safety data, and discussing future directions. Recent findings CMR has become an important component of risk stratification and procedural planning in numerous congenital and pediatric heart diseases. Innovative approaches to image acquisition and reconstruction are leading the way toward fast, high-resolution, three- and four-dimensional datasets for delineation of cardiac anatomy, function, and flow. In addition, techniques for assessing the composition of the myocardium may help elucidate the pathophysiology of late complications, identify patients at risk for heart failure, and assist in the evaluation of therapeutic strategies. Summary CMR provides invaluable morphologic, hemodynamic, and functional data that help guide diagnosis, assessment, and management of pediatric and adult congenital heart disease. As imaging techniques advance and data accumulate on the relative and additive value of CMR in patient care, its role in a multimodality approach to the care of this population of patients is becoming clear and is likely to continue to evolve.
Boot cAMP.

Richard Feins, MD (program director) University of North Carolina Jon Nesbitt, MD (course director) Vanderbilt University Mark Ferguson, MD University of Chicago William Lynch, MD University of Iowa Varun Puri, MD Washington University Julian Guitron, MD University of Cincinnati Darryl Weinman, MD MD Anderson Harmik J. Soukiasian, MD Cedars-Sinai Medical Center Tom Daniel, MD Senior Tour/University of Virginia Carolyn Jones, MD University of Rochester Joe Miller, MD Senior Tour/Emory University Alberto de Hoyos, MD Northwestern University Paul Schipper, MD Northwestern University Mark Allen, MD Mayo Clinic
Pre-P Is a Secreted Glycoprotein Encoded as an N-Terminal Extension of the Duck Hepatitis B Virus Polymerase Gene

ABSTRACT The duck hepatitis B virus (DHBV) pregenomic RNA is a bicistronic mRNA encoding the core and polymerase proteins. Thirteen AUGs (C2 to C14) and 10 stop codons (S1 to S10) are located between the C1 AUG for the core protein and the P1 AUG that initiates polymerase translation. We previously found that the translation of the DHBV polymerase is initiated by ribosomal shunting. Here, we assessed the biosynthetic events after shunting. Translation of the polymerase open reading frame was found to initiate at the C13, C14, and P1 AUGs. Initiation at the C13 AUG occurred through ribosomal shunting because translation from this codon was cap dependent but was insensitive to blocking ribosomal scanning internally in the message. C13 and C14 are in frame with P1, and translation from these upstream start codons led to the production of larger isoforms of P. We named these isoforms “pre-P” by analogy to the pre-C and pre-S regions of the core and surface antigen open reading frames. Pre-P was produced in DHBV16 and AusDHBV-infected duck liver and was predicted to exist in 80% of avian hepadnavirus strains. Pre-P was not encapsidated into DHBV core particles, and the viable strain DHBV3 cannot make pre-P, so it is not essential for viral replication. Surprisingly, we found that pre-P is an N-linked glycoprotein that is secreted into the medium of cultured cells. These data indicate that DHBV produces an additional protein that has not been previously reported. Identifying the role of pre-P may improve our understanding of the biology of DHBV infection.
Unconscious processing at the subjective threshold : semantic comprehension?

Our thoughts and behaviours can sometimes be influenced by stimuli that we are not consciously aware of having seen. For example, the presentation of a word that is blocked from entering conscious visual perception through masking can subsequently influence the cognitive processing of a further target word. However, the idea that unconscious cognition is sophisticated enough to process the semantic meaning of subliminal stimuli is controversial. This thesis attempts to explore the extent of subliminal priming. Empirical research centering on subjective methods of measuring conscious knowledge is presented in a series of three articles. The first article investigates the subliminal priming of negation. A series of experiments demonstrates that unconscious processing can accurately discriminate between two nouns beyond chance performance when subliminally instructed to either pick or not pick a given noun. This article demonstrates not only semantic processing of the instructional word, but also unconscious cognitive control by following a two-word subliminal instruction to not choose the primed noun. The second article investigates subliminal priming of active versus passive verb voice by presenting a prime sentence denoting one of two characters as either active or passive and asking which of two pictorial representations best matches the prime. The series of experiments demonstrates that overall, participants were able to identify the correct image for both active and passive conditions beyond chance expectations. This article suggests that individuals are able to process the meaning of word combinations that they are not aware of seeing. The third article attempts to determine whether subliminal processing is sophisticated enough to allow for the activation of specific anxieties relating to relationships. Whilst the findings reveal a small subliminal priming effect on generalised anxiety, the evidence regarding the subliminal priming of very specific anxieties is insensitive. The unconscious is shown in these experiments to be more powerful than previously supposed in terms of the fine grained processing of the semantics of word combinations, though not yet in terms of the fine grained resolution of emotional priming.
A Partitioning Method of Cooperative Caching with Hit Frequency Counters for Many-Core Processors

The number of processor cores on a chip tends to increase because of the limitation of single thread performance. For many-core architectures, efficient use of last-level cache (LLC) is important. Recent techniques which have been proposed are core-divided LLC and forward an evicted line from one cache to another cache. In this paper, we propose a new cache partitioning scheme of HFC (Hit Frequency Counters), which is inspired by RFF (Reference Frequency Filter), to detect a rarely used cache region. We apply HFC partitioning to a core-divided LLC scheme to have such regions being shared with other cores. Our evaluation shows that the reduction of the number of off chip access over the base partitioning scheme is 5.0% on average and 25.8% at a maximum.
Human Brain Imaging and Radiation Dosimetry of 11C-N-Desmethyl-Loperamide, a PET Radiotracer to Measure the Function of P-Glycoprotein

P-glycoprotein (P-gp) is a membrane-bound efflux pump that limits the distribution of drugs to several organs of the body. At the blood–brain barrier, P-gp blocks the entry of both loperamide and its metabolite, N-desmethyl-loperamide (N-dLop), and thereby prevents central opiate effects. Animal studies have shown that 11C-dLop, compared with 11C-loperamide, is an especially promising radiotracer because it generates negligible radiometabolites that enter the brain. The purposes of this study were to determine whether 11C-dLop is a substrate for P-gp at the blood–brain barrier in humans and to measure the distribution of radioactivity in the entire body to estimate radiation exposure. Methods: Brain PET scans were acquired in 4 healthy subjects for 90 min and included concurrent measurements of the plasma concentration of unchanged radiotracer. Time–activity data from the whole brain were quantified using a 1-tissue-compartment model to estimate the rate of entry (K1) of radiotracer into the brain. Whole-body PET scans were acquired in 8 healthy subjects for 120 min. Results: For brain imaging, after the injection of 11C-dLop the concentration of radioactivity in the brain was low (standardized uptake value, ∼15%) and stable after approximately 20 min. In contrast, uptake of radioactivity in the pituitary was about 50-fold higher than that in the brain. The plasma concentration of 11C-dLop declined rapidly, but the percentage composition of plasma was unusually stable, with the parent radiotracer constituting 85% of total radioactivity after approximately 5 min. The rate of brain entry was low (K1 = 0.009 ± 0.002 mL·cm−3·min−1; n = 4). For whole-body imaging, as a measure of radiation exposure to the entire body the effective dose of 11C-dLop was 7.8 ± 0.6 μSv/MBq (n = 8). Conclusion: The low brain uptake of radioactivity is consistent with 11C-dLop being a substrate for P-gp in humans and confirms that this radiotracer generates negligible quantities of brain-penetrant radiometabolites. In addition, the low rate of K1 is consistent with P-gp rapidly effluxing substrates while they transit through the lipid bilayer. The radiation exposure of 11C-dLop is similar to that of many other 11C-radiotracers. Thus, 11C-dLop is a promising radiotracer to study the function of P-gp at the blood–brain barrier, at which impaired function would allow increased uptake into the brain.
Modality of fear cues affects acoustic startle potentiation but not heart-rate response in patients with dental phobia

The acoustic startle response (SR) has consistently been shown to be enhanced by fear-arousing cross-modal background stimuli in phobics. Intra-modal fear-potentiation of acoustic SR was rarely investigated and generated inconsistent results. The present study compared the acoustic SR to phobia-related sounds with that to phobia-related pictures in 104 dental phobic patients and 22 controls. Acoustic background stimuli were dental treatment noises and birdsong and visual stimuli were dental treatment and neutral control pictures. Background stimuli were presented for 4 s, randomly followed by the administration of the startle stimulus. In addition to SR, heart-rate (HR) was recorded throughout the trials. Irrespective of their content, background pictures elicited greater SR than noises in both groups with a trend for phobic participants to show startle potentiation to phobia-related pictures but not noises. Unlike controls, phobics showed HR acceleration to both dental pictures and noises. HR acceleration of the phobia group was significantly positively correlated with SR in the noise condition only. The acoustic SR to phobia-related noises is likely to be inhibited by prolonged sensorimotor gating.
HoVerTable: Dual-sided Vertical Mid-air Images on Horizontal Tabletop Display

Tabletop displays have been used to share information among multiple users. However, there are two problems with current tabletop displays: The display area is limited to horizontal surfaces, and there is a lack of view-dependent appearance regarding displayed images. The aim of this paper is to overcome these limitations by adding dual-sided vertical mid-air images to a horizontal surface for a richer and more impressive visual presentation. For this purpose, we introduce a plate-shaped mid-air imaging optics as a tabletop surface and a diffusion control film for the projection of horizontal images. The proposed system, "HoVerTable," can display a combination of horizontal and vertical images for users facing each other. We have developed interactive applications on HoVerTable, including a card battle game and an application for the augmentation of physical objects.