Miracle-dz/UniFAR-FTUs huggingface dataset:
A Structured Analysis of SQL Injection Runtime Mitigation Techniques

SQL injection attacks (SQLIA) still remain one of the most commonly occurring and exploited vulnerabilities. A considerable amount of research concerning SQLIA mitigation techniques has been conducted with the primary resulting solution requiring developers to code defensively. Although, defensive coding is a valid solution, the current market demand for websites is being filled by inexperienced developers with little knowledge of secure development practices. Unlike the successful case of ASLR, no SQLIA runtime mitigation technique has moved from research to enterprise use. This paper presents an in-depth analysis and classification, based on Formal Concept Analysis, of the 10 major SQLIA runtime mitigation techniques. Based on this analysis, one technique was identified that shows the greatest potential for transition to enterprise use. This analysis also serves as an enhanced SQLIA mitigation classification system. Future work includes plans to move the selected SQLIA runtime mitigation technique closer to enterprise use.
Novel T3SS effector EseK in Edwardsiella piscicida is chaperoned by EscH and EscS to express virulence

Bacterium usually utilises type III secretion systems (T3SS) to deliver effectors directly into host cells with the aids of chaperones. Hence, it is very important to identify bacterial T3SS effectors and chaperones for better understanding of host–pathogen interactions. Edwardsiella piscicida is an invasive enteric bacterium, which infects a wide range of hosts from fish to human. Given E. piscicida encodes a functional T3SS to promote infection, very few T3SS effectors and chaperones have been identified in this bacterium so far. Here, we reported that EseK is a new T3SS effector protein translocated by E. piscicida. Bioinformatic analysis indicated that escH and escS encode two putative class I T3SS chaperones. Further investigation indicated that EscH and EscS can enhance the secretion and translocation of EseK. EscH directly binds EseK through undetermined binding domains, whereas EscS binds EseK via its N‐terminal α‐helix. We also found that EseK has an N‐terminal chaperone‐binding domain, which binds EscH and EscS to form a ternary complex. Zebrafish infection experiments showed that EseK and its chaperones EscH and EscS are necessary for bacterial colonisation in zebrafish. This work identified a new T3SS effector, EseK, and its two T3SS chaperones, EscH and EscS, in E. piscicida, which enriches our knowledge of bacterial T3SS effector–chaperone interaction and contributes to our understanding of bacterial pathogenesis.
The HIV treatment cascade in acutely infected people: informing global guidelines

Purpose of reviewAcute and early HIV (AHI) is a pivotal time during HIV infection, yet there remain major shortfalls in diagnosis, linkage to care, and antiretroviral therapy (ART) initiation during AHI. We introduce an AHI-specific cascade, review recent evidence pertaining to the unique challenges of AHI, and discuss strategies for improving individual and public health outcomes. Recent findingsPresentation during AHI is common. Expanding use of fourth-generation testing and pooled nucleic acid amplification testing has led to improved AHI detection in resource-wealthy settings. Technologies capable of AHI diagnosis are rare in resource-limited settings; further development of point-of-care devices and utilization of targeted screening is needed. Rapid ART initiation during AHI limits reservoir seeding, preserves immunity, and prevents transmission. Reporting of AHI cascade outcomes is limited, but new evidence suggests that impressive rates of diagnosis, linkage to care, rapid ART initiation, and viral suppression can be achieved. SummaryWith advancements in AHI diagnostics and strong evidence for the therapeutic and prevention benefits of ART initiated during AHI, improving AHI cascade outcomes is both crucial and feasible. HIV guidelines should recommend diagnostic algorithms capable of detecting AHI and prescribe rapid, universal ART initiation during AHI.
Virtual reality in your living room

environment—the living room. The project builds on an eight-year series of research projects in which the authors explore the boundaries between the virtual and the physical and I would encourage readers to read them all. A key ingredient in the authors’ approach to tackling AR/VR at home is the use of depth cameras, a type of device already available in the living room through Microsoft’s Xbox gaming console. The camera is a key component, because it allows the authors to integrate their system with the living room. Rather than shutting out the room, as head-worn VR displays would, the authors digitize the living room and integrate it into the user’s experience. They achieve all this with “living roomcompatible” components. And rather than replace what they find in the living room, the authors augment it. They appropriate the TV and use an augmented reality approach to creating what might be considered more of a VR experience. Ultimately, what impresses me about IllumiRoom is that it asks how virtual and real reality should come together. When I was a research scientist at Xerox PARC in the early 2000s, I was in the process of creating very large screens by combining flat panel displays with projection. I showed my prototype to the late Rich Gold, who liked the idea and agreed with my pitch about the productivity gains such big screens could provide. However, he was critical of my plan to simply maximize screen real estate. Bigger screens, he argued, were a trade-off: each piece allows users to access more virtuality, but at the expense of giving up a piece of the physical reality. And that is what the IllumiRoom authors excel at: creating a virtual reality while being mindful of the physical world.
TITLE : EVIDENCE OF DISTURBED SLEEP AND INCREASED ILLNESS IN 1 OVERREACHED ENDURANCE ATHLETES

30 31 Purpose: To examine whether i) objective markers of sleep quantity and quality are altered in 32 endurance athletes experiencing overreaching in response to an overload training program and ii) 33 whether potential reduced sleep quality would be accompanied with higher prevalence of upper 34 respiratory tract infections in this population. 35 Methods: Twenty seven trained male triathletes were randomly assigned to either overload (n=18) or 36 normal (CTL, n=9) training groups. Respective training programs included a 1-week moderate training 37 phase, followed by a 3-week period of overload or normal training, respectively and then a subsequent 38 2-week taper. Maximal aerobic power and oxygen uptake ( ̇O2max) from incremental cycle ergometry 39 were measured after each phase, whilst mood states and incidences of illness were determined from 40 questionnaires. Sleep was monitored every night of the 6 weeks using wristwatch actigraphy. 41 Results: Nine of the 18 overload training group subjects were diagnosed as functionally overreached 42 (F-OR) after the overload period, as based on declines in performance and ̇O2max with concomitant 43 high perceived fatigue (p<0.05), whilst the nine other overload subjects showed no decline in 44 performance (AF, p>0.05). There was a significant time × group interaction for sleep duration (SD), 45 sleep efficiency (SE) and immobile time (IT). Only the F-OR group demonstrated a decrease in these 46 three parameters (-5.4±5.3%, -2.1±2.0% and -5.7±5.0%, for SD, SE and IT, respectively, p<0.05), 47 which was reversed during the subsequent taper phase. Higher prevalence of upper respiratory tract 48 infections were also reported in F-OR (67%, 22%, 11% incidence rate, for F-OR, AF and CTL, 49 respectively). 50 Conclusion: This study confirms sleep disturbances and increased illness in endurance athletes who 51 present with symptoms of F-OR during periods of high volume training. 52 53
Hybridization between subspecies of waterbuck (Kobus ellipsiprymnus) in zones of overlap with limited introgression

Two subspecies of waterbuck (Kobus ellipsiprymnus), common (Kobus ellipsiprymnus ellipsiprymnus) and defassa (Kobus ellipsiprymnus defassa), are recognized based on differences in rump pattern, coat colour and geographical distribution. These forms are parapatrically distributed with an area of range overlap in East Africa, where phenotypically intermediate populations occur. Variation in 478 bp of the mitochondrial DNA control region and 14 polymorphic microsatellite loci were used to describe the genetic structure and phylogeographical pattern of the species, and to assess if the intermediate populations are the results of hybridization. In total, 186 individuals from 11 localities were analysed. A high degree of genetic differentiation was found between subspecies, although this was most evident from the microsatellite data. Hybridization was suggested in the phenotypically and geographically intermediate Nairobi NP population in Kenya. A neighbour‐joining (NJ) tree based on microsatellite population genetic distances grouped Nairobi between the common and defassa populations, and a Bayesian analysis clearly showed introgression. Individuals sampled in Samburu NP, Kenya, had a common waterbuck phenotype, but introgression was suggested by both markers. Although a high degree of maternal defassa input was indicated from the sequence data, the Samburu population grouped with the common waterbuck in the microsatellite population genetic distance tree, with high support. Analyses of linkage disequilibrium and maximum‐likelihood estimates of genetic drift suggested that admixture between subspecies is a recent event. The fact that introgression is limited between subspecies could be caused by chromosomal differences, hindering gene flow between common and defassa waterbuck.
Automation of summarization evaluation methods and their application to the summarization process

Summarization is the process of creating a more compact textual representation of a document or a collection of documents. In view of the vast increase in electronically available information sources in the last decade, filters such as automatically generated summaries are becoming ever more important to facilitate the efficient acquisition and use of required information. Different methods using natural language processing (NLP) techniques are being used to this end. One of the shallowest approaches is the clustering of available documents and the representation of the resulting clusters by one of the documents; an example of this approach is the Google News website. It is also possible to augment the clustering of documents with a summarization process, which would result in a more balanced representation of the information in the cluster, NewsBlaster being an example. However, while some systems are already available on the web, summarization is still considered a difficult problem in the NLP community. One of the major problems hampering the development of proficient summarization systems is the evaluation of the (true) quality of system-generated summaries. This is exemplified by the fact that the current state-of-the-art evaluation method to assess the information content of summaries, the Pyramid evaluation scheme, is a manual procedure. In this light, this thesis has three main objectives. 1. The development of a fully automated evaluation method. The proposed scheme is rooted in the ideas underlying the Pyramid evaluation scheme and makes use of deep syntactic information and lexical semantics. Its performance improves notably on previous automated evaluation methods. 2. The development of an automatic summarization system which draws on the conceptual idea of the Pyramid evaluation scheme and the techniques developed for the proposed evaluation system. The approach features the algorithm for determining the pyramid and bases importance on the number of occurrences of the variable-sized contributors of the pyramid as opposed to word-based methods exploited elsewhere. 3. The development of a text coherence component that can be used for obtaining the best ordering of the sentences in a summary.
Character-based Bidirectional LSTM-CRF with words and characters for Japanese Named Entity Recognition

Recently, neural models have shown superior performance over conventional models in NER tasks. These models use CNN to extract sub-word information along with RNN to predict a tag for each word. However, these models have been tested almost entirely on English texts. It remains unclear whether they perform similarly in other languages. We worked on Japanese NER using neural models and discovered two obstacles of the state-of-the-art model. First, CNN is unsuitable for extracting Japanese sub-word information. Secondly, a model predicting a tag for each word cannot extract an entity when a part of a word composes an entity. The contributions of this work are (1) verifying the effectiveness of the state-of-the-art NER model for Japanese, (2) proposing a neural model for predicting a tag for each character using word and character information. Experimentally obtained results demonstrate that our model outperforms the state-of-the-art neural English NER model in Japanese.
Somatization in Primary Care: A Comparative Survey of Immigrants from Various Ethnic Groups in Rome, Italy

Objectives: Those responsible for interviewing immigrants in primary care settings often underestimate the importance of somatic symptoms arising from psychological distress. This study investigates the current prevalence of somatization in immigrants, and evaluates the comparative rates of somatic complaints in four ethnic groups (Caucasians, Asians, South/Center Americans, and Africans). Methods: We studied the 301 consecutive outpatients (aged between 16 and 70 years) attending the “Caritas” primary care unit for immigrants in Rome (Italy) from January to December 2003, all of whom completed the 21-item version of the Bradford Somatic Inventory (BSI-21). Patients scoring 14 or more on the BSI-21 were considered at risk for somatization. Results: The current prevalence of somatization was 35.2%; 62.3% of the somatizers were women. A multiple regression analysis adjusting for the possible confounding effects of sex, age, education, and months of stay in Italy showed that South/Central Americans had significantly higher somatization scores than the other three groups. Conclusions: These findings suggest a high probability of somatization syndromes in immigrant patients. South/Central Americans tend to somatize more than other ethnic groups. A psychosomatic approach may be useful for immigrants in primary care settings.
Assessment of the hepatic microvascular changes in liver cirrhosis by perfusion computed tomography.

AIM To assess the hepatic microvascular parameters in patients with liver cirrhosis by perfusion computed tomography (CT). METHODS Perfusion CT was performed in 29 patients without liver disease (control subjects) and 39 patients with liver cirrhosis, including 22 patients with compensated cirrhosis and 17 patients with decompensated cirrhosis, proved by clinical and laboratory parameters. CT cine-scans were obtained over 50 s beginning with the injection of 50 mL of contrast agent. Hepatic microvascular parameters, mean transit time (MTT) and permeability surface area product (PS) were obtained with the Perfusion 3 software (General Electric, ADW 4.2). RESULTS The overall differences of MTT and PS between control subjects, patients with compensated cirrhosis and those with decompensated cirrhosis were statistically significant (P = 0.010 and P = 0.002, respectively). MTT values were 15.613 +/- 4.1746 s, 12.592 +/- 4.7518 s, and 11.721 +/- 4.5681 s for the three groups, respectively, while PS were 18.945 +/- 7.2347 mL/min per 100 mL, 22.767 +/- 8.3936 mL/min per 100 mL, and 28.735 +/- 13.0654 mL/min per 100 mL. MTT in decompensated cirrhotic patients were significantly decreased compared to controls (P = 0.017), whereas PS values were remarkably increased (P = 0.001). CONCLUSION The hepatic microvascular changes in patients with liver cirrhosis can be quantitatively assessed by perfusion CT. Hepatic microvascular parameters (MTT and PS), as measured by perfusion CT, were significantly altered in decompensated cirrhosis.
Mapping of ligand‐binding cavities in proteins

The complex interactions between proteins and small organic molecules (ligands) are intensively studied because they play key roles in biological processes and drug activities. Here, we present a novel approach to characterize and map the ligand‐binding cavities of proteins without direct geometric comparison of structures, based on Principal Component Analysis of cavity properties (related mainly to size, polarity, and charge). This approach can provide valuable information on the similarities and dissimilarities, of binding cavities due to mutations, between‐species differences and flexibility upon ligand‐binding. The presented results show that information on ligand‐binding cavity variations can complement information on protein similarity obtained from sequence comparisons. The predictive aspect of the method is exemplified by successful predictions of serine proteases that were not included in the model construction. The presented strategy to compare ligand‐binding cavities of related and unrelated proteins has many potential applications within protein and medicinal chemistry, for example in the characterization and mapping of “orphan structures”, selection of protein structures for docking studies in structure‐based design, and identification of proteins for selectivity screens in drug design programs. Proteins 2010. © 2009 Wiley‐Liss, Inc.
Frequency reconfigurable quasi-Yagi antenna using variable-length transmission line resonator

This paper presents a frequency reconfigurable wideband quasi-Yagi antenna. This antenna is fed by a microstrip line to slot line transition structure and two parasitic strips as directors. The transition feed consists of a microstrip circular stub and a slot circular stub, with different Radius to achieve wideband impedance matching. The reconfigurability of this antenna can be achieved by tuning the length of the transmission line resonator placed on the bottom of slot line transition. Ideal switches were used to control the length of the resonators. Simulated results of the antenna, demonstrate a good performances of the proposed designs such ass compactness, radiation patterns and diversity gain.
Quasi-2-Dimensional Compact Resistor Model for the Drift Region in High-Voltage LDMOS Devices

High-voltage (HV) metal-oxide-semiconductor field-effect transistors (MOSFETs) of the laterally diffused metal-oxide-semiconductor (LDMOS) type enable applications over a wide range of bias voltages by optimizing the combined structure of MOSFET and drift region at its drain side. We report a physically accurate compact resistor model of the LDMOS drift region, adapted to the special requirements of the combined structure with a MOSFET. In particular, the reported resistor model captures the effects of the 2-D current flow in the drift region with its complicated bias dependence. The resistor model considers two device-structure-dependent potentials, namely, the internal node potential within the highly resistive drift region and the potential underneath the gate overlap region. The consistent potential-based description over the complete LDMOS device is the key modeling technology for enabling the accurate reproduction of the bias-dependent 2-D current flow and the resulting I-V characteristics for a wide range of structure variations with a small number of only six fitting parameters. The reported quasi-2-D resistor model is implemented in the second-generation Hiroshima-university STARC IGFET Model-High Voltage (HiSIM-HV) compact models for HV MOSFETs and is expected to be useful for both, optimization of LDMOS circuits and devices.
NF 1 germline mutation differentially dictates optic glioma formation and growth in neuro fi bromatosis-1

Neurofibromatosis type 1 (NF1) is a common neurogenetic condition characterized by significant clinical heterogeneity. A major barrier to developing precision medicine approaches for NF1 is an incomplete understanding of the factors that underlie its inherent variability. To determine the impact of the germline NF1 genemutation on the optic gliomas frequently encountered in children with NF1, we developed genetically engineered mice harboring two representative NF1-patient-derived Nf1 gene mutations (c.2542G>C;p.G848R and c.2041C>T;p.R681X). We found that each germline Nf1 gene mutation resulted in different levels ofneurofibromin expression. Importantly, onlyR681X but notG848R,mice developoptic gliomaswith increasedoptic nerve volumes, glial fibrillary acid protein immunoreactivity, proliferation and retinal ganglion cell death, similar to Nf1 conditional knockout mice harboring a neomycin insertion (neo) as the germline Nf1 gene mutation. These differences in optic glioma phenotypes reflect both cell-autonomous and stromal effects of the germline Nf1 gene mutation. In this regard, primary astrocytes harboring the R681X germline Nf1 gene mutation exhibit increased basal astrocyte proliferation (BrdU incorporation) indistinguishable fromneo astrocytes,whereas astrocyteswith theG848Rmutationhave lower levels of proliferation. Evidence for paracrine effects from the tumor microenvironment were revealed when R681X mice were compared with conventional neo mice. Relative to neo mice, the optic gliomas from R681X mice had more microglia infiltration and JNK activation,microglia-producedCcl5, and glial AKT activation. Collectively, these studies establish that the germlineNf1 gene mutation is a major determinant of optic glioma development and growth through by both tumor cell-intrinsic and stromal effects.
The Murrumbidgee soil moisture monitoring network data set

This paper describes a soil moisture data set from the 82,000 km2 Murrumbidgee River Catchment in southern New South Wales, Australia. Data have been archived from the Murrumbidgee Soil Moisture Monitoring Network (MSMMN) since its inception in September 2001. The Murrumbidgee Catchment represents a range of conditions typical of much of temperate Australia, with climate ranging from semiarid to humid and land use including dry land and irrigated agriculture, remnant native vegetation, and urban areas. There are a total of 38 soil moisture‐monitoring sites across the Murrumbidgee Catchment, with a concentration of sites in three subareas. The data set is composed of 0–5 (or 0–8), 0–30, 30–60, and 60–90 cm average soil moisture, soil temperature, precipitation, and other land surface model forcing at all sites, together with other ancillary data. These data are available on the World Wide Web at http://www.oznet. org.au.
Circulating Fractalkine Levels Predict the Development of the Metabolic Syndrome

The fractalkine/CX3CR1 axis plays an important role in regulating glucose and lipid metabolism. However, the role of fractalkine in metabolic disorders remains to be fully elucidated. We selected 887 Chinese (40–65 years old) at baseline, with a subgroup of 459 participants examined again 2 years later. The relationship of serum fractalkine levels with the metabolic syndrome (MetS) and its components was investigated. At baseline, participants with MetS had higher fractalkine concentrations than their counterparts without MetS (P < 0.001). At the 2-year follow-up, participants in the highest quartile of baseline fractalkine exhibited higher values for body mass index, waist circumference, waist-to-hip ratio, body fat percentage, glucose, insulin, total cholesterol, triglycerides (TG), and homeostasis model assessment of insulin resistance (HOMA-IR) and lower value for high density lipoprotein-cholesterol (HDL-c) (all P < 0.05). Among 390 participants without MetS at baseline, 45 developed it at year 2. Even after multiple adjustments for visceral adipose tissue area, HOMA-IR, C-reactive protein (CRP), or TG and HDL-c, baseline fractalkine predicted the development of MetS (OR = 7.18, 95%CI: 2.28–18.59). In conclusion, circulating fractalkine predicts the development of the MetS independently of central obesity, CRP, insulin resistance, and dyslipidemia.