Miracle-dz/UniFAR-FTUs huggingface dataset:
Exercise adherence in breast cancer survivors training for a dragon boat race competition: a preliminary investigation

Recent research has applied the theory of planned behavior (TPB) to understanding exercise after a cancer diagnosis, but studies are few and have been limited by retrospective designs, self‐report measures of exercise and varied results. In the present study, we extended this research by using a prospective design and an objective measure of exercise adherence. Participants were a convenience sample of 24 breast cancer survivors attending a twice weekly, 12‐week training program in preparation for a dragon boat race competition. Participants completed a baseline questionnaire that assessed demographic and medical variables, past exercise, and the TPB (i.e. beliefs, subjective norm, attitude, perceived behavioral control and intention). Program attendance was monitored over a 12‐week period by the class instructor. Overall, participants attended 66% of the training sessions. Multiple regression analyses indicated that: (a) intention was the sole determinant of program attendance and explained 35% of the variance; (b) the TPB constructs explained 49% of the variance in intention with subjective norm being the most important determinant; and (c) the key underlying beliefs were support from physician, spouse, and friends, and confidence in being able to attend the training class when having limited time, no one to exercise with, fatigue, and other health problems. Based on this preliminary study, it was concluded that the TPB may provide a good framework on which to base interventions designed to promote exercise in breast cancer survivors. Copyright © 2001 John Wiley & Sons, Ltd.
Human Adipose-Derived Mesenchymal Stromal Cells Injected Systemically into GRMD Dogs without Immunosuppression are Able to Reach the Host Muscle and Express Human Dystrophin

Duchenne muscular dystrophy (DMD), a lethal X-linked disorder, is the most common and severe form of muscular dystrophies, affecting 1 in 3,500 male births. Mutations in the DMD gene lead to the absence of muscle dystrophin and a progressive degeneration of skeletal muscle. The possibility to treat DMD through cell therapy has been widely investigated. We have previously shown that human adipose-derived stromal cells (hASCs) injected systemically in SJL mice are able to reach and engraft in the host muscle, express human muscle proteins, and ameliorate the functional performance of injected animals without any immunosuppression. However, before starting clinical trials in humans many questions still need to be addressed in preclinical studies, in particular in larger animal models, when available. The best animal model to address these questions is the golden retriever muscular dystrophy (GRMD) dog that reproduces the full spectrum of human DMD. Affected animals carry a mutation that predicts a premature termination codon in exon 8 and a peptide that is 5% the size of normal dystrophin. These dogs present clinical signs within the first weeks and most of them do not survive beyond age two. Here we show the results of local and intravenous injections of hASCs into GRMD dogs, without immunosuppression. We observed that hASCs injected systemically into the dog cephalic vein are able to reach, engraft, and express human dystrophin in the host GRMD dystrophic muscle up to 6 months after transplantation. Most importantly, we demonstrated that injecting a huge quantity of human mesenchymal cells in a large-animal model, without immunosuppression, is a safe procedure, which may have important applications for future therapy in patients with different forms of muscular dystrophies.
Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis.

RATIONALE Pulmonary infection in cystic fibrosis (CF) is polymicrobial and it is possible that anaerobic bacteria, not detected by routine aerobic culture methods, reside within infected anaerobic airway mucus. OBJECTIVES To determine whether anaerobic bacteria are present in the sputum of patients with CF. METHODS Sputum samples were collected from clinically stable adults with CF and bronchoalveolar lavage fluid (BALF) samples from children with CF. Induced sputum samples were collected from healthy volunteers who did not have CF. All samples were processed using anaerobic bacteriologic techniques and bacteria within the samples were quantified and identified. MEASUREMENTS AND MAIN RESULTS Anaerobic species primarily within the genera Prevotella, Veillonella, Propionibacterium, and Actinomyces were isolated in high numbers from 42 of 66 (64%) sputum samples from adult patients with CF. Colonization with Pseudomonas aeruginosa significantly increased the likelihood that anaerobic bacteria would be present in the sputum. Similar anaerobic species were identified in BALF from pediatric patients with CF. Although anaerobes were detected in induced sputum samples from 16 of 20 volunteers, they were present in much lower numbers and were generally different species compared with those detected in CF sputum. Species-dependent differences in the susceptibility of the anaerobes to antibiotics with known activity against anaerobes were apparent with all isolates susceptible to meropenem. CONCLUSIONS A range of anaerobic species are present in large numbers in the lungs of patients with CF. If these anaerobic bacteria are contributing significantly to infection and inflammation in the CF lung, informed alterations to antibiotic treatment to target anaerobes, in addition to the primary infecting pathogens, may improve management.
Developmental expression patterns of four chemosensory protein genes from the Eastern spruce budworm, Chroistoneura fumiferana

Chemosensory proteins (CSPs) are associated with insect sensory organs, including the sensillum lymph in some cases. However, they are also commonly expressed in nonsensory tissues that lack gustatory and olfactory neurones. We characterized the sex and development specific expression patterns of four CSP genes from the Eastern spruce budworm (ESB) using Northern blots. CfumAY426540.2 was detected at high levels in adult moths. Conversely, CfumAY426538 was expressed in all stages except adult moths, and was most abundant during late stages of the 6th instar. CfumAY701858 was expressed in all stages, while CfumAY426539 was detected less frequently, at specific developmental stages such as the 5th to 6th instar moult. During a natural moult, and a premature moult induced by the ecdysteroid agonist tebufenozide, CfumAY701858 and CfumAY426539 were up‐regulated, while CfumAY426538 appeared to be down‐regulated. Our results suggest that some members of the CSP gene family from the ESB may be involved in development, including moulting.
Top Executives' Reactions to Change

This article focuses on the role of justice and exemplarity perceptions on top executives' reactions to change. Drawing on extensive interview material from French top managers facing a requirement for change, the empirical analysis sheds light upon the importance of procedural justice and exemplarity in mitigating negative reactions to change. The empirical material suggests that procedural justice acts as a hygiene factor to prevent the change requirement being rejected as illegitimate, and that exemplarity acts as a motivator factor for top executives to enact the required change. These findings imply that special care should be dedicated to both procedural justice and exemplarity as key antecedents for change acceptance among top executives.
Investigating the Dynamics of Authentic Learning in a Project-based Engineering Course

Educational researchers and practitioners have long lamented the chasm between education and real-world experiences or issues. A popular way to mitigate this gap is through designing authentic learning experiences, and much previous work has focused on developing models for this design. The paper addresses a gap in such frameworks, namely the occurrence of tensions and negotiations between ways of working that students and teachers find authentic and meaningful. Focusing on the strategies employed by teachers in the design of an authentic learning environment and students’ reactions to these, we present a qualitative case study of a project-based engineering course in which student teams created software applications in collaboration with an external stakeholder. We find that tensions between what students and teachers deemed meaningful arose from on the one hand students’ readiness to take on self-directed learning and on the other hand differences between disciplinary views and students’ habits of mind related to software development. We illustrate how the teachers’ ability to bridge these tensions seemed hinged on their understanding of students’ prior learning experiences, and the enminding of these into learning activities. To enhance the value of contemporary models of authentic learning as practical and explanatory frameworks, we argue for adding two theoretical constructs – tensions and negotiations – and we call for more and longitudinal research on these
The Development and Performance Characterization of Turbine Prototypes for a MEMS Spirometer

The design, optimization, and performance characterization of turbine prototypes for the development of a Microelectromechanical Systems spirometer is reported. Four different turbines were designed based on large-scale Savonius turbine architecture. The number of turbine blades was optimized through finite-element simulations to maximize the induced moment and rotational speed at normal breathing flow rates. The turbines were manufactured and tested for their speed performance with respect to input flow rate, pressure difference, and actuation power, showing good agreement with the simulation results. The highest rotational speed was achieved with involute-bladed turbine design with eight blades, and was measured to be 10.56 kr/min at the peak 25-lpm flow rate. Real-life testing with this design was carried out on healthy subjects to demonstrate its capability of performing respiration flow rate measurements. The turbine prototypes presented in this paper allow for the development of low-cost and portable MEMS spirometers for remote- and self-monitoring of lung malfunctions in chronic obstructive pulmonary disease and asthma diseases.
Rapid characterization of the normal and disturbed vaginal microbiota by application of 16S rRNA gene terminal RFLP fingerprinting.

Bacterial vaginosis (BV) is a prevalent infection in women of reproductive age associated with numerous sequelae, including preterm delivery, amniotic fluid infections and an increased risk of acquiring sexually transmitted diseases. The vaginal microbiota in BV patients is characterized by a shift from lactobacilli to a diverse spectrum of mostly anaerobic bacteria. In this study, terminal restriction fragment length polymorphism (T-RFLP) was used to characterize the vaginal bacterial communities from 50 women with BV and 20 healthy subjects. In the BV samples, 23 species or phylotypes from 17 genera could be identified, including Atopobium vaginae, Megasphaera sp. , Lactobacillus iners, Gardnerella vaginalis and three recently described phylotypes from the order Clostridiales. The number of detected species or phylotypes was on average 6.3 per sample (range 2-14). In contrast, in normal samples, only Lactobacillus species could be identified. In conclusion, T-RFLP provides a rapid and reliable technique to investigate the diversity of the predominant vaginal microbiota and allows differentiation of the flora of BV and healthy women. As such, T-RFLP may be helpful both in the diagnosis of BV from vaginal fluids and in a better understanding of the bacterial succession involved in the aetiology of BV.
Automated Posterior Cranial Fossa Volumetry by MRI: Applications to Chiari Malformation Type I

BACKGROUND AND PURPOSE: Quantification of PCF volume and the degree of PCF crowdedness were found beneficial for differential diagnosis of tonsillar herniation and prediction of surgical outcome in CMI. However, lack of automated methods limits the clinical use of PCF volumetry. An atlas-based method for automated PCF segmentation tailored for CMI is presented. The method performance is assessed in terms of accuracy and spatial overlap with manual segmentation. The degree of association between PCF volumes and the lengths of previously proposed linear landmarks is reported. MATERIALS AND METHODS: T1-weighted volumetric MR imaging data with 1-mm isotropic resolution obtained with the use of a 3T scanner from 14 patients with CMI and 3 healthy subjects were used for the study. Manually delineated PCF from 9 patients was used to establish a CMI-specific reference for an atlas-based automated PCF parcellation approach. Agreement between manual and automated segmentation of 5 different CMI datasets was verified by means of the t test. Measurement reproducibility was established through the use of 2 repeated scans from 3 healthy subjects. Degree of linear association between PCF volume and 6 linear landmarks was determined by means of Pearson correlation. RESULTS: PCF volumes measured by use of the automated method and with manual delineation were similar, 196.2 ± 8.7 mL versus 196.9 ± 11.0 mL, respectively. The mean relative difference of −0.3 ± 1.9% was not statistically significant. Low measurement variability, with a mean absolute percentage value of 0.6 ± 0.2%, was achieved. None of the PCF linear landmarks were significantly associated with PCF volume. CONCLUSIONS: PCF and tissue content volumes can be reliably measured in patients with CMI by use of an atlas-based automated segmentation method.
Revascularization treatment of stable coronary artery disease

Introduction: Coronary artery disease (CAD) is the leading cause of mortality in developed countries. Angina, myocardial infarction, heart failure and other clinical manifestations of coronary atherosclerosis lead to considerable patient morbidity and constitute an increasingly heavy burden on health systems worldwide. Areas covered: This article reviews the recent major developments in the treatment of CAD, which can be achieved using medical therapy either in isolation or in combination with revascularization, performed via coronary artery bypass surgery (CABG) or percutaneous coronary intervention (PCI). There is no dispute that optimal medical treatment is the cornerstone of CAD management; however, timely revascularization offers superior symptom control in patients with severe symptoms and may also offer a survival advantage in some patients with diffuse disease and diabetes. Importantly, the advances in PCI technology, especially with the introduction of drug-eluting stents has narrowed the gap between CABG and PCI for the treatment of CAD. Expert opinion: The continuous developments in diagnosis and treatment of CAD call for contemporary trials with detailed analysis to provide evidence that will help in the choice of the best and most cost-effective treatment strategy.
At‐risk mental state (ARMS) detection in a community service center for early attention to psychosis in Barcelona

Aim: To describe the strategy and some results in at‐risk mental state (ARMS) patient detection as well as some of the ARMS clinical and socio‐demographical characteristics. The subjects were selected among the patients visited by an Early Care Equipment for patients at high risk of psychoses, in Barcelona (Spain) during its first year in operation.
Leadership Style and Organizational Citizenship Behavior in Community-Based Mental Health Facilities

Leadership Style and Organizational Citizenship Behavior in Community-Based Mental Health Facilities by Paula Ann Lucey MS, Marquette University, 1988 BS, University of Wisconsin-Milwaukee, 1976 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Management August 2017 Abstract A dramatic and historic evolution has occurred as mental health care has shifted from institutional-based care to community-based care. Framed by the social exchange theory,A dramatic and historic evolution has occurred as mental health care has shifted from institutional-based care to community-based care. Framed by the social exchange theory, the purpose of this study was to identify the correlation of the leadership style of supervisors in residential care facilities with the organizational citizenship behavior of the residential care workers. The research questions focused on the correlation between the leadership styles and organizational citizenship behavior (OCB) with a secondary focus specifically on transformational leadership. Residential care workers in 3 states working in 65 facilities within a single organization completed 2 surveys: the Multifactor Leadership Questionnaire and the Organizational Citizenship Behavior Checklist. Fortynine completed surveys were returned. The transactional leadership style was correlated to OCB in 2 defining subfactors: contingency reward r(42)=. 424, p < . 001 and management by exception/active r(42)=. 417, p <. 001. The transformational leadership style was correlated to OCB in 4 defining subfactors: idealized behaviors r(42)=. 388, p <. 001, instrumental motivation r(42)=. 417, p <. 001, idealized influence r(42)=. 395, p <. 001, and individual consideration r(42)=. 371, p <. 005. These findings have not been previously reported in mental health residential care settings. The generalizability of this study is limited by sample size and scope, because the employees come from facilities within a single corporate organization. Residential care is part of the overall positive social change in care of the mentally ill, by offering the mentally ill the opportunity of an enhanced, community-based life. This study begins the process of ensuring that sufficient evidence-based knowledge and scholarly practitioners are available to lead work that benefits this vulnerable population; additional study is recommended. Leadership Style and Organizational Citizenship Behavior in Community-Based Mental Health Facilities by Paula Ann Lucey MS, Marquette University, 1988 BS, University of Wisconsin-Milwaukee, 1976 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Management
Towards an Understanding of Side-Lining Environmental Sustainability in Formula E: Traditional Values and the Emergence of eSports

The electric racing series of Formula E is the motor sport‟s governing body‟s latest initiative to promote and generate more sustainable transport. The question remains however if its attempt to go “green” is simply a smokescreen for yet another commodity spectacle. By means of a mixed method approach, this study investigates the selfrepresentation of Formula E in relation to environmental sustainability and factors of commodification. Results suggest that Formula E makes use of marketing and educational advantages that come with adopting an environmentally sustainable approach to motor sport. Although this means Formula E does not escape the grasp of commodification, much like Formula One, it also implies that, probably for the first time ever, motor sport has taken a significant initiative to become more environmentally and socially sustainable.
An accurate measurement method for optical radiation loss of silicon-on-insulator curved waveguides

Silicon-on-insulator (SOI) photonic integrated circuits have recently become a research topic of great interest due to their compact confinements and compatibility with the modern micro-electronics. Low-loss SOI curved waveguides are attracting attention as they offer solutions to the dominant issue of integration density of planar lightwave circuits on a single SOI chip. Propagation loss and radiation loss rate of SOI curved waveguides are accurately measured by using Fabry-Perot interferometric method with the help of an optical vector analyzer (Luna system). The presented technique provides a universal solution for optical loss measurement of photonic integrated chips.
Common and unique gray matter correlates of episodic memory dysfunction in frontotemporal dementia and alzheimer's disease

Conflicting evidence exists regarding the integrity of episodic memory in the behavioral variant of frontotemporal dementia (bvFTD). Recent converging evidence suggests that episodic memory in progressive cases of bvFTD is compromised to the same extent as in Alzheimer's disease (AD). The underlying neural substrates of these episodic memory deficits, however, likely differ contingent on dementia type. In this study we sought to elucidate the neural substrates of episodic memory performance, across recall and recognition tasks, in both patient groups using voxel‐based morphometry (VBM) analyses. We predicted that episodic memory dysfunction would be apparent in both patient groups but would relate to divergent patterns of neural atrophy specific to each dementia type. We assessed episodic memory, across verbal and visual domains, in 19 bvFTD, 18 AD patients, and 19 age‐ and education‐matched controls. Behaviorally, patient groups were indistinguishable for immediate and delayed recall, across verbal and visual domains. Whole‐brain VBM analyses revealed regions commonly implicated in episodic retrieval across groups, namely the right temporal pole, right frontal lobe, left paracingulate gyrus, and right anterior hippocampus. Divergent neural networks specific to each group were also identified. Whereas a widespread network including posterior regions such as the posterior cingulate cortex, parietal and occipital cortices was exclusively implicated in AD, the frontal and anterior temporal lobes underpinned the episodic memory deficits in bvFTD. Our results point to distinct neural changes underlying episodic memory decline specific to each dementia syndrome. Hum Brain Mapp 35:1422–1435, 2014. © 201 Wiley Periodicals, Inc.
Modeling Virtual Laboratory of Motion Control

With the development of the Internet and the information technology, virtual laboratory may provide students and users with the vivid expression of the theory and the real performance of the physical world. Moreover, by means of the Internet, virtual lab brings the benefits of the space and time. In this paper, a virtual lab of motion control is described that a completely new system which will be shown to students and users throughout virtualization and networking. They can not only upload the software coded which can be called by the real executive system, but also understand the features of basic motion control via sending back real data by the Internet and the aim of the system is to provide an opening-up and sharing space for students' researching and learning.
Submovements during reaching movements after stroke

Neurological deficits after cerebrovascular accidents very frequently disrupt the kinematics of voluntary movements with the consequent impact in daily life activities. Robotic methodologies enable the quantitative characterization of specific control deficits needed to understand the basis of functional impairments and to design effective rehabilitation therapies. In a group of right handed chronic stroke survivors (SS) with right side hemiparesis, intact proprioception, and differing levels of motor impairment, we used a robotic manipulandum to study right arm function during discrete point-to-point reaching movements and reciprocal out-and-back movements to visual targets. We compared these movements with those of neurologically intact individuals (NI). We analyzed the presence of secondary submovements in the initial (i.e. outward) trajectory portion of the two tasks and found that the SS with severe impairment (FM <; 30) presented arm submovements that differed notably not only from NI but also from those of SS with moderate arm impairment (FM 30-50). Therefore the results of this pilot study suggest that in SS arm kinematics vary significantly across differing levels of motor impairment. Our results support the development of rehabilitation therapies carefully tailored to each individual stroke survivor.