Miracle-dz/UniFAR-FTUs huggingface dataset:
A technology portable analytical model for DSM CMOS inverter short-circuit power estimation

In this paper, an accurate analytical model for DSM (deep sub-micron) CMOS inverter short-circuit power estimation is presented. Unlike previous works, which always require extracted or fitting parameters, the proposed model depends only on the inverter dimension and SPICE parameters. Its accuracy and portability have been validated by comparing with BSIM3v3 MOSFET model simulation results for TSMC 0.18 /spl mu/m and UMC 0.13 /spl mu/m CMOS technologies, and for a wide range of inverter sizes, input transition times, and capacitive loads. The relative error is less than 15% in most cases, showing very good agreement with Spectre simulation.
The Hierarchy of Ethical Consumption Behavior

Consumers need to move to more sustainable/ethical behavior. Previous research has explored changing consumption with most studies concentrating on specific aspects of sustainable/ethical consumption. This study uses a full range of citizen defined ethical choices. Applying Rasch modeling to consumers' reports of ethically motivated consumption choices, a hierarchy of ethical choices is created. This hierarchy of ethical consumption choices allows the application of stages of change theory to progress consumers up the hierarchy of ethical choices, with implications for public policy, pressure groups and consumers.
Mobile phone text messaging for pharmaceutical care in a hospital in China

We have developed a mobile pharmacy service system (MPSS) to deliver individualized pharmaceutical care via text messages sent to the mobile phones of patients. The text messages were: (1) reminders about medication – from the day following discharge, reminder messages were automatically sent to patients approximately 10 minutes before their medication was due to be taken. The system stopped sending messages when the prescription ran out and suggested that patients should come to hospital to renew any prescribed medicines; (2) practical information about medicines, such as information about methods of administration; (3) information about adverse drug reactions. In a 3-month trial in a general hospital, 100 patients were provided with pharmaceutical care using the MPSS for an average of 3.5 medicines per patient (range 1–9). They received pharmaceutical care for an average of 12 days per patient (range 3–19). A survey was then conducted which indicated that most patients were satisfied with the pharmaceutical care provided by MPSS through text messages, and that they had positive attitudes despite some limitations. The use of the MPSS should improve pharmaceutical care, widen the knowledge of pharmacists, reduce the burden on pharmacy staff, improve pharmacist–patient interaction, and improve the effect and safety of medication.
Ubiquitination of the Human Immunodeficiency Virus Type 1 Env Glycoprotein

ABSTRACT Expression of the human immunodeficiency virus type 1 (HIV-1) Env glycoprotein is stringently regulated in infected cells. The majority of the glycoprotein does not reach the cell surface but rather is retained in the endoplasmic reticulum or a cis-Golgi compartment and subsequently degraded. We here report that Env of various HIV-1 isolates is ubiquitinated at the extracellular domain of gp41 and that Env expression could be increased by lactacystin, a specific proteasome inhibitor, suggesting that the ubiquitin/proteasome system is involved in control of expression and degradation.
Daytime sodium airglow emission measurements over Trivandrum using a scanning monochromator: first results

Abstract. This paper presents measurement of daytime Sodium (Na) airglow emissions at 589.6 nm wavelength using a ground based 1-m scanning monochromator from Trivandrum (8.5° N, 77° E, 0.5° N dip latitude), a near-equatorial station in India. The Na emission intensity exhibits significant temporal variability within a day and from one day to another. The Na intensity has been compared with the daytime OH airglow intensity at 731.6 nm simultaneously measured using the unique Multiwavelength Dayglow Photometer (MWDPM). The temporal variabilities of the Na and OH intensities corroborate each other in most of the occasions without any appreciable time delay, although a small time delay up to ~10 min has been observed at times. It appears that the variability of daytime Na emissions is influenced too by the photo-chemical excitations. The observed similarities in the Na and OH intensities are believed to be due to the similar roles played by [O] and O 3 (in their photo-chemical excitations) and the dynamics occurring at about the same altitude region (~90 km). It has also been found that the gravity waves play significant role in producing the short-scale oscillations in these emissions.
Impact of T wave amplitude in lead aVR on predicting cardiac events in ischemic and nonischemic cardiomyopathy patients with an implantable cardioverter defibrillator

T wave amplitudes during ventricular repolarization in the lead aVR (TAaVR) are shown to be associated with adverse cardiac events in patients with several cardiovascular diseases, such as postmyocardial infarction. However, the utility of TAaVR has not been previously evaluated in patients with cardiomyopathy who have received implantable cardioverter defibrillators (ICD). Patients with ischemic or nonischemic cardiomyopathy (ICM or NICM, respectively) and who received an ICD may experience worsening of their condition due to the introduction of electric shock during treatment. This study aimed to investigate the utility of TAaVR in the prediction of cardiac events in ICM or NICM patients with ICD.
The potential of virtual reality in social skills training for people with autistic spectrum disorders.

BACKGROUND People with autism experience profound and pervasive difficulties in the social domain. Attempts to teach social behaviours tend to adopt either a behavioural or a 'theory of mind' (ToM) approach. The beneficial aspects and limitations of both paradigms are summarized before an examination of how virtual reality technology may offer a way to combine the strengths from both approaches. METHODS This is not an exhaustive review of the literature; rather, the papers are chosen as representative of the current understanding within each broad topic. Web of Science ISI, EMBASE and PsycInfo were searched for relevant articles. RESULTS Behavioural and ToM approaches to social skills training achieve some success in improving specific skills or understanding. However, the failure to generalize learned behaviours to novel environments, and the unwieldy nature of some behavioural methodologies, means that there is a need for a training package that is easy to administer and successful in promoting learning across contexts. CONCLUSIONS Virtual reality technology may be an ideal tool for allowing participants to practise behaviours in role-play situations, whilst also providing a safe environment for rule learning and repetition of tasks. Role-play within virtual environments could promote the mental simulation of social events, potentially allowing a greater insight into minds. Practice of behaviours, both within and across contexts, could also encourage a more flexible approach to social problem solving. Virtual environments offer a new and exciting perspective on social skills training for people with autistic spectrum disorders.
In vitro Selection and Interaction Studies of a DNA Aptamer Targeting Protein A

A new DNA aptamer targeting Protein A is presented. The aptamer was selected by use of the FluMag-SELEX procedure. The SELEX technology (Systematic Evolution of Ligands by EXponential enrichment) is widely applied as an in vitro selection and amplification method to generate target-specific aptamers and exists in various modified variants. FluMag-SELEX is one of them and is characterized by the use of magnetic beads for target immobilization and fluorescently labeled oligonucleotides for monitoring the aptamer selection progress. Structural investigations and sequence truncation experiments of the selected aptamer for Protein A led to the conclusion, that a stem-loop structure at its 5’-end including the 5’-primer binding site is essential for aptamer-target binding. Extensive interaction analyses between aptamer and Protein A were performed by methods like surface plasmon resonance, MicroScale Thermophoresis and bead-based binding assays using fluorescence measurements. The binding of the aptamer to its target was thus investigated in assays with immobilization of one of the binding partners each, and with both binding partners in solution. Affinity constants were determined in the low micromolar to submicromolar range, increasing to the nanomolar range under the assumption of avidity. Protein A provides more than one binding site for the aptamer, which may overlap with the known binding sites for immunoglobulins. The aptamer binds specifically to both native and recombinant Protein A, but not to other immunoglobulin-binding proteins like Protein G and L. Cross specificity to other proteins was not found. The application of the aptamer is directed to Protein A detection or affinity purification. Moreover, whole cells of Staphylococcus aureus, presenting Protein A on the cell surface, could also be bound by the aptamer.
Diabetes dose titration identification model

Diabetes is a chronic disease that requires continuous treatment throughout lifespan and increased risk opportunity of developing a number of serious health problems, which are high treatment cost. Admitted diabetes inpatients should receive the appropriate treatment in order to reduce rating of severe complications and premature death. This paper aims to develop the classification model for diabetic medication adjustment based on historical medical record of diabetic inpatients by applying three algorithms; Decision Tree, Naive Bayes and Artificial neural network By comparison of the results of each method, Decision Tree is outperformed than others for Independent Dose Titration Model (IDT) dataset and Artificial Neural Network algorithm generated model with high accuracy and ROC Curve for Historical Dose Titration Model (HDT) dataset. The results of this paper could support the decision making in medication adjustment of diabetes inpatients, particularly type-2 diabetes inpatients.
Sterol Intermediates from Cholesterol Biosynthetic Pathway as Liver X Receptor Ligands*

The liver X receptors (LXRs) are ligand-activated transcription factors that regulate the expression of genes controlling lipid metabolism. Oxysterols bind LXRs with high affinity in vitro and are implicated as ligands for the receptor. We showed previously that accumulation of selected dietary sterols, in particular stigmasterol, is associated with activation of LXR in vivo. In the course of the defining of structural features of stigmasterol that confer LXR agonist activity, we determined that the presence of an unsaturated bond in the side chain of the sterol was necessary and sufficient for activity, with the C-24 unsaturated cholesterol precursor sterols desmosterol and zymosterol exerting the largest effects. Desmosterol failed to increase expression of the LXR target gene, ABCA1, in LXRα/β-deficient mouse fibroblasts, but was fully active in cells lacking cholesterol 24-, 25-, and 27-hydroxylase; thus, the effect of desmosterol was LXR-dependent and did not require conversion to a side chain oxysterol. Desmosterol bound to purified LXRα and LXRβ in vitro and supported the recruitment of steroid receptor coactivator 1. Desmosterol also inhibited processing of the sterol response element-binding protein-2 and reduced expression of hydroxymethylglutaryl-CoA reductase. These observations are consistent with specific intermediates in the cholesterol biosynthetic pathway regulating lipid homeostasis through both the LXR and sterol response element-binding protein pathways.
Office quality classification theoretical and empirical issues

Office quality classification literature recognises identification of office classes through division of office market rent distribution into intervals but failed to provide sound theoretical framework and comprehensive empirical approach to this method. This paper theorised that as office rental levels are a function of office quality; high quality office classes should have their mean rents greater than average market rent and mean rents of low quality classes. Also that heterogeneous nature of property coupled with lack of perfect information to market participants could result into differential evaluation of rent and quality of the same property by different market participants. The behaviour of participants normally reflects in distribution of market rent by depicting natural breaks in the distribution that could be captured by univariate data exploration. Frequency and histograms of rent distributions that were assumed to depict the behaviour of market participants were used to divide rent distribution to intervals to identify office quality classes. The results of this classification were validated by discriminant analysis. 67% and 59% accuracies were achieved for estimation and holdout subsamples respectively. This paper extended theoretical and empirical approaches in office quality classification. The proposed empirical approach could be used in future classification research.
Innovation height, spillovers and tfp growth at the firm level: Evidence from French manufacturing

The author examines the contribution of incremental and radical innovations to total factor productivity (TFP) growth at the firm level. The first part of our analysis is dedicated to the determinants of innovation and reveals two different innovation regimes. On the one hand, radical innovations rely strongly on firm-level spillovers, including property rights, and formal internal research, whereas on the other hand, incremental innovations rely mostly on the adoption of equipment goods accompanied by informal research. It is found that radical innovations are the only significant contributors to TFP growth, so that innovation height matters. Evidences show that TFP growth is better represented by an upward shift of the production function than by a continuous innovation measure. Overall, the growth gains found are comparable to the ones of the previous studies.
A novel core-shell lipid nanoparticle for improving oral administration of water soluble chemotherapeutic agents: inhibited intestinal hydrolysis and enhanced lymphatic absorption

Abstract The oral administration of water-soluble chemotherapeutical agents is limited by their serious gastrointestinal side effects, instability at intestinal pH, and poor absorption. Aiming to solve these problems, we chose topotecan (TPT) as a model drug and developed a novel lipid formulation containing core-shell lipid nanoparticle (CLN) that makes the water-soluble drug to ‘dissolve’ in oil. TPT molecules can be encapsulated into nanoparticles surrounded by oil barrier while avoiding the direct contact with intestinal environment, thus easing the intestinal hydrolytic degradation and gastrointestinal (GI) irritation. Microstructure and mean particle size of TPT-CLN were characterized by Transmission Electron Microscope (TEM) and Dynamic Light Scattering (DLS), respectively. The average size of nanoparticles was approximately 60 nm with a homogeneous distribution in shapes of spheres or ellipsoid. According to in vitro stability studies, more initial form of TPT was observed in presence of lipid nanoparticle compared with free topotecan solution in artificial intestinal juice (pH 6.5). After oral administration of TPT-CLN in rats, AUC and Cmax of TPT were all increased compared with free TPT, indicating significant enhancement of oral absorption. Intestinal lymphatic transport was confirmed as the major way for CLN to enhance oral absorption of TPT by the treatment of blocking chylomicron flow. Lower GI irritation of TPT-CLN was observed in the gastrointestinal damage studies. The in vivo antitumor activity of TPT-CLN showed an improved antitumor efficacy by oral treatment of TPT-CLN compared to free TPT. From the obtained data, the systems appear an attractive progress in oral administration of topotecan.
Stock-market efficiency in thin-trading markets: the case of the Vietnamese stock market

This article reviews developments in the Stock Trading Centre (STC) in Ho Chi Minh City, Vietnam, the main stock market in the country, since its start in 2000. It presents information about developments in the number of stocks traded, trading activity and stock-price developments. This article focuses on the question whether the market is weak-form efficient. An important element of the investigation concerns the possible bias of the results caused by the thin trading that characterizes the STC. Stock-market returns are corrected for this. The main conclusion is that the STC is not efficient in the weak form.
Ownership Structure and Accounting Conservatism: A Literature Review

With the rapid development of modern corporate theory, the divergence of interests of shareholders and management began to increase, leading to more and more conflicts between the shareholders and managers. The agency problem hindered the company and shareholders to maximize their value. A reasonable ownership structure and sound accounting information can alleviate the problems caused by the agency conflict. Therefore, many scholars began to research the relationship between ownership structure and accounting conservatism. This article summarizes the relevant literature mainly from the ownership concentration, the degree of equity checks and balances, institutional ownership and state ownership of these four aspects, in order to provide theoretical support for the follow-up study.
Employment, Politics, and Economic Recovery during the Great Depression

In earlier studies, economic historians found that political goals, rather than social or humanitarian objectives, motivated much of New Deal spending. Using new information on annual, state level employment for the 1930s, this paper shows that, while politics are still important, responding to the needs of the unemployed was an important determinant of New Deal spending.
Differential Impact of Intracellular Carboxyl Terminal Domains on Lipid Raft Localization of the Murine Gonadotropin-Releasing Hormone Receptor

Abstract The mammalian type I GNRH receptor (GNRHR) is unique among G protein-coupled receptors (GPCRs) because of the absence of an intracellular C-terminus. Previously, we have found that the murine GNRHR is constitutively localized to low-density membrane microdomains termed lipid rafts. As such, association of the GNRHR with lipid rafts may reflect both a loss (C-terminus) and a gain (raft association address) of structural characteristics. To address this, we fused either the full-length C-terminus from the nonraft-associated LH receptor (LHCGR; GNRHR-LF) or a truncated (t631) LHCGR C-terminus to the GNRHR. These chimeric receptors are trafficked to the plasma membrane, bind ligand, and display increased agonist-induced receptor internalization, but they do not partition into lipid rafts. Thus, a heterologous C-terminus from a nonraft-associated GPCR redirects localization of the GNRHR to nonraft domains. In contrast to the murine GNRHR, the catfish GNRHR (cfGNRHR) possesses an intracellular C-terminus. We found that the cfGNRHR was localized to lipid rafts and that the cfGNRHR C-terminus did not alter raft localization of the mammalian receptor. Consistent with placement in different lipid microenvironments within the plasma membrane, fluorescence recovery after photobleaching revealed different lateral diffusion phenotypes of the raft-associated GNRHR and cfGNRHR versus the nonraft-associated GNRHR-LF fusion protein. We conclude that whereas an intracellular C-terminus is capable of redirecting the GNRHR to nonraft compartments, this is not a generalized feature of GPCR C-terminal tails. Thus, constitutive raft localization of the GNRHR is not simply a result of the loss of an intracellular C-terminus.
Australia's Image as a Holiday Destination-Perceptions of Backpacker Visitors

Abstract Destination image has been identified as a pivotal aspect of promotion strategy (Eastlack, 1982; Hunt, 1975; Goodrich, 1978; Reilly, 1990; Woodside, 1982; and Woodside and Jacobs, 1985). According to Echtner and Ritchie (1991, 1993) destination image is comprised of three dimensions; attribute vs. holistic, functional vs. psychological, and unique vs. common, and is best measured using a combination of structured and unstructured methodologies. The aim of this study was to employ both methodologies in the measurement of Australia's destination image as perceived by backpacker travellers. The results indicated that Australia's major strengths are its natural attractions and its friendly people, as well as safety, climate and language spoken. The two areas of most concern were its lower ratings on interesting culture and travel cost. Some of the unique elements of Australia's image included kangaroos, the Great Barrier Reef, the Outback, Aboriginal culture, and Ayers Rock/ Uluru. Holistic components included its vastness, diversity and stunning natural wonders. These findings have practical and theoretical implications for destination image management.
Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor

CB1 cannabinoid receptors (CB1Rs) are attractive therapeutic targets for numerous central nervous system disorders. However, clinical application of cannabinoid ligands has been hampered owing to their adverse on-target effects. Ligand-biased signaling from, and allosteric modulation of, CB1Rs offer pharmacological approaches that may enable the development of improved CB1R drugs, through modulation of only therapeutically desirable CB1R signaling pathways. There is growing evidence that CB1Rs are subject to ligand-biased signaling and allosterism. Therefore, in the present study, we quantified ligand-biased signaling and allosteric modulation at CB1Rs. Cannabinoid agonists displayed distinct biased signaling profiles at CB1Rs. For instance, whereas 2-arachidonylglycerol and WIN55,212-2 [(R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-napthalenylmethanone] showed little preference for inhibition of cAMP and phosphorylation of extracellular signal-regulated kinase 1/2 (pERK1/2), N-arachidonoylethanolamine (anandamide), methanandamide, CP55940 [2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol], and HU-210 [11-hydroxy-Δ8-THC-dimethylheptyl] were biased toward cAMP inhibition. The small-molecule allosteric modulator Org27569 [5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)ethyl]amide] displayed biased allosteric effects by blocking cAMP inhibition mediated by all cannabinoid ligands tested, at the same time having little or no effect on ERK1/2 phosphorylation mediated by a subset of these ligands. Org27569 also displayed negative binding cooperativity with [3H]SR141716A [5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide]; however, it had minimal effects on binding of cannabinoid agonists. Furthermore, we highlight the need to validate the reported allosteric effects of the endogenous ligands lipoxin A4 and pregnenolone at CB1Rs. Pregnenolone but not lipoxin A4 displaced [3H]SR141716A, but there was no functional interaction between either of these ligands and cannabinoid agonists. This study demonstrates an approach to validating and quantifying ligand-biased signaling and allosteric modulation at CB1Rs, revealing ligand-biased “fingerprints” that may ultimately allow the development of improved CB1R-targeted therapies.