Miracle-dz/UniFAR-FTUs huggingface dataset:
Natural Killer Cell Sensing of Infected Cells Compensates for MyD88 Deficiency but Not IFN-I Activity in Resistance to Mouse Cytomegalovirus

In mice, plasmacytoid dendritic cells (pDC) and natural killer (NK) cells both contribute to resistance to systemic infections with herpes viruses including mouse Cytomegalovirus (MCMV). pDCs are the major source of type I IFN (IFN-I) during MCMV infection. This response requires pDC-intrinsic MyD88-dependent signaling by Toll-Like Receptors 7 and 9. Provided that they express appropriate recognition receptors such as Ly49H, NK cells can directly sense and kill MCMV-infected cells. The loss of any one of these responses increases susceptibility to infection. However, the relative importance of these antiviral immune responses and how they are related remain unclear. In humans, while IFN-I responses are essential, MyD88 is dispensable for antiviral immunity. Hence, a higher redundancy has been proposed in the mechanisms promoting protective immune responses against systemic infections by herpes viruses during natural infections in humans. It has been assumed, but not proven, that mice fail to mount protective MyD88-independent IFN-I responses. In humans, the mechanism that compensates MyD88 deficiency has not been elucidated. To address these issues, we compared resistance to MCMV infection and immune responses between mouse strains deficient for MyD88, the IFN-I receptor and/or Ly49H. We show that selective depletion of pDC or genetic deficiencies for MyD88 or TLR9 drastically decreased production of IFN-I, but not the protective antiviral responses. Moreover, MyD88, but not IFN-I receptor, deficiency could largely be compensated by Ly49H-mediated antiviral NK cell responses. Thus, contrary to the current dogma but consistent with the situation in humans, we conclude that, in mice, in our experimental settings, MyD88 is redundant for IFN-I responses and overall defense against a systemic herpes virus infection. Moreover, we identified direct NK cell sensing of infected cells as one mechanism able to compensate for MyD88 deficiency in mice. Similar mechanisms likely contribute to protect MyD88- or IRAK4-deficient patients from viral infections.
Molecular characterization of the first leptospires isolated from goats in Brazil

Two Leptospira sp. isolates were obtained by the first time from goats in Brazil and characterized by sequencing rrs, rpoB and secY genes, PFGE and typing with monoclonal antibodies. Both isolates are identical and belong to Leptospira santarosai. Analysis of the rrs and the rpoB genes sequences revealed 100% identity between the goat isolates and the Bananal reference strain. When secY sequences of the two isolates were compared to each other, it was observed that they had identical sequences. However, when compared to that of the Bananal reference strain, there were 15 mismatches along the 549 bp secY sequence. In conclusion, molecular methods are increasingly useful for the characterization of leptospires and allowed to identify those isolates of caprine origin as closely related but not identical to serovar Bananal, and constitute a new type named Carioca.
An Extensible Framework for Provenance in Human Terrain Visual Analytics

We describe and demonstrate an extensible framework that supports data exploration and provenance in the context of Human Terrain Analysis (HTA). Working closely with defence analysts we extract requirements and a list of features that characterise data analysed at the end of the HTA chain. From these, we select an appropriate non-classified data source with analogous features, and model it as a set of facets. We develop ProveML, an XML-based extension of the Open Provenance Model, using these facets and augment it with the structures necessary to record the provenance of data, analytical process and interpretations. Through an iterative process, we develop and refine a prototype system for Human Terrain Visual Analytics (HTVA), and demonstrate means of storing, browsing and recalling analytical provenance and process through analytic bookmarks in ProveML. We show how these bookmarks can be combined to form narratives that link back to the live data. Throughout the process, we demonstrate that through structured workshops, rapid prototyping and structured communication with intelligence analysts we are able to establish requirements, and design schema, techniques and tools that meet the requirements of the intelligence community. We use the needs and reactions of defence analysts in defining and steering the methods to validate the framework.
Polarization profiles of southern pulsars at 3.1 GHz

We present polarization profiles for 48 southern pulsars observed with the new 10-cm receiver at the Parkes telescope. We have exploited the low system temperature and high bandwidth of the receiver to obtain profiles which have good signal-to-noise for most of our sample at this relatively high frequency. Although, as expected, a number of profiles are less linearly polarized at 3.1 GHz than at lower frequencies, we identify some pulsars and particular components of profiles in other pulsars which have increased linear polarization at this frequency. We discuss the dependence of linear polarization with frequency in the context of a model in which emission consists of the superposition of two, orthogonally polarized modes. We show that a simple model, in which the orthogonal modes have different spectral indices, can explain many of the observed properties of the frequency evolution of both the linear polarization and the total power, such as the high degree of linear polarization seen at all frequencies in some high spin-down, young pulsars. Nearly all the position angle profiles show deviations from the rotating vector model; this appears to be a general feature of high-frequency polarization observations.
Pseudomonas aeruginosa Enhances Production of an Antimicrobial in Response to N-Acetylglucosamine and Peptidoglycan

ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen often associated with chronic lung infections in individuals with the genetic disease cystic fibrosis (CF). Previous work from our laboratory revealed that five genes predicted to be important for catabolism of N-acetylglucosamine (GlcNAc) are induced during in vitro growth in CF lung secretions (sputum). Here, we demonstrate that these genes comprise an operon (referred to as the nag operon) and that NagE, a putative component of the GlcNAc phosphotransferase system, is required for growth on and uptake of GlcNAc. Using primer extension analysis, the promoter of the nag operon was mapped and shown to be inducible by GlcNAc and regulated by the transcriptional regulator NagR. Transcriptome analysis revealed that in addition to induction of the nag operon, several P. aeruginosa genes encoding factors critical for extracellular antimicrobial production are also induced by GlcNAc. Finally, we show that the GlcNAc-containing polymer peptidoglycan induces production of the antimicrobial pyocyanin. Based on this data, we propose a model in which P. aeruginosa senses surrounding bacteria by monitoring exogenous peptidoglycan and responds to this cue through enhanced production of an antimicrobial.
Pertes d'eau et de solutés durant l'irrigation de laitues romaines en sols organiques : comparaison de méthodes d'évaluation et impacts sur les rendements

Irrigation has to be optimised because of its impact on yield and solute leaching to groundwater. The first objective of this project was thus to compare four methods of estimating water flux: a lysimeter pan (reference method), a flux based on daily evapotranspirative demand, a water balance computed from changes in water storage and évapotranspiration demand and finally, an estimation based on Darcy's law. The second objective was to evaluate the impact of irrigation on lettuce yield and on nitrate, phosphate and bromide leaching in organic soil. Our data suggest that the estimation methods overestimate the drainage, compared to the one calculated with the lysimeter pan. Also, no effect on leaching and on yield was observed from irrigation treatments, and solute losses toward groundwater were small.
On the equivalence of idealised DVFS and thermally constrained DPM in real-time systems

Modern real-time embedded systems have increasingly penetrated our daily life and are also often constrained in terms of temperature and energy. In this paper, a thesis is defended that from a real-time systems perspective, thermally constrained dynamic power management approaches behave very similar to idealised dynamic voltage and frequency scaling. Hence, existing dynamic voltage and frequency scaling solutions proposed for periodic/sporadic task models can be applied to thermally constrained dynamic power management systems with moderate effort. This work presents the similarities along with the distinctive elements between two approaches. Within the case study, the porting of a dynamic voltage and frequency scaling algorithm of the literature to thermally constrained dynamic power management system is demonstrated.
Chapter 6 Evaluation of Photocatalytic Activity of the TiO 2 Layer Formed on Ti by Thermal Oxidation

Two-step thermal oxidation was proposed for Ti and Ti alloys as a surface-treatment process for preparing an anatase-containing TiO2 layer. This process consisted of treatment in a CO-containing atmosphere (first step) and subsequent treatment in air (second step). In this chapter, first, the current status of TiO2 coating onto Ti and Ti alloys for biomedical applications is reviewed; then our recent work on the phase and microstructure of TiO2 layers prepared on commercially pure (CP) Ti, Ti-25mass%Mo alloy, and Ti-25mass%Nb alloy by two-step thermal oxidation is described. The anatase fraction in the TiO2 layer was controlled through process parameters such as the second-step temperature. Finally, photocatalytic activity of TiO2 layers formed on the Ti and Ti alloys is evaluated, including: results of water contact angle, decomposition of methylene blue, and antibacterial effects.
Performance Analysis of WiMAX Networks with Relay Station

IEEE 802.16 is a Broadband Wireless Access (BWA) network and thus it is considered to be an alternative solution to wired broadband technologies. Relay station plays a promising role of extending the range of Base station for long distances in WiMAX networks. Relay station is suitable to areas with limited infrastructure such as rural, hilly and lakes, where it is difficult to install many Base stations with each having wired connections and it is also suitable to those phases where obstacles made the coverage limited. The Relay station is placed in the network connectivity from Base stations and extends the coverage of a single Base station. In this paper the performance analysis of WiMAX technology including Relay station has been done. This paper also focuses on increasing number of nodes and distance from base station to the performance of WiMAX networks.
Myosin II Is Involved in the Production of Constitutive Transport Vesicles from the TGN

The participation of nonmuscle myosins in the transport of organelles and vesicular carriers along actin filaments has been documented. In contrast, there is no evidence for the involvement of myosins in the production of vesicles involved in membrane traffic. Here we show that the putative TGN coat protein p200 (Narula, N., I. McMorrow, G. Plopper, J. Doherty, K.S. Matlin, B. Burke, and J.L. Stow. 1992. J. Cell Biol. 114: 1113–1124) is myosin II. The recruitment of myosin II to Golgi membranes is dependent on actin and is regulated by G proteins. Using an assay that studies the release of transport vesicles from the TGN in vitro, we provide functional evidence that p200/myosin is involved in the assembly of basolateral transport vesicles carrying vesicular stomatitis virus G protein (VSVG) from the TGN of polarized MDCK cells. The 50% reduced efficiency in VSVG vesicle release from the TGN in vitro after depletion of p200/myosin II could be reestablished to control levels by the addition of purified nonmuscle myosin II. Several inhibitors of the actin-stimulated ATPase activity of myosin specifically inhibited the release of VSVG-containing vesicles from the TGN.
Identifying Priority Health Conditions, Environmental Data, and Infrastructure Needs: A Synopsis of the Pew Environmental Health Tracking Project

In this article we describe the methodologic approaches of the Pew Environmental Health Commission at the Johns Hopkins Bloomberg School of Public Health used to identify priority environmental health conditions and develop recommendations to establish a national environmental public health tracking network. We present the results of a survey of public health and environmental practitioners to uncover state and local health tracking needs and priorities. We describe the steps that combined the findings from the state and local health tracking survey and a review of the state of the science on environmental impacts on health to identify priority health end points. Through an examination of national health and health care databases, we then describe trends and public health effects of those diseases that may be linked to the environment. Based on this analysis, respiratory diseases and neurologic diseases are recommended as priorities for tracking. Specific end points recommended for tracking include asthma and chronic respiratory diseases, and chronic neurodegenerative diseases such as multiple sclerosis. Based on trends in reported prevalence, consideration should also be given to developmental disabilities, reproductive disorders, and endocrine/metabolic disorders. Strengthening of current efforts to track cancer and birth defects should also be included as components of a nationwide health tracking network. Finally, we present the recommendations for environmental public health tracking. These recommendations provided the groundwork for the development of the Centers for Disease Control and Prevention’s National Environmental Public Health Tracking Progam that now includes 21 states, three cities, and three academic centers throughout the nation.
Immunohistochemical Observations in the Ceca of Chickens Infected with Salmonella enteritidis Phage Type Four 1

One-day-old specific-pathogen-free White Leghorn chicks were inoculated orally with Salmonella enteritidis phage type 4 to study adhesion and invasion of the ceca by immunohistochemistry. Positive staining bacilli were associated with the epithelial surface and were present in the lumen of the cecal crypts. They were observed in the interstitial tissue and in the cytoplasm of macrophage-like cells in the lamina propria. A granulomatous nodule containing positive staining bacilli was present in the submucosa of the cecum of one bird at 14 d after inoculation. (
Algorithm of denoising based on point cloud segmentation

The undesirable noise will inevitably occur in the generation of the triangular mesh. Therefore, how to effectively remove the noise has become an important project in the computer graphics. By the point cloud segmentation approach we can denoise the data just only for the characteristic point, thereby reducing the number of point cloud processing and precision. This paper proposes an algorithm which can smooth nosing data quickly. Experimental result proves the validity of the algorithm.
What are we measuring? Convergence of leadership with interpersonal and non-interpersonal personality.

Since leadership styles have been most commonly defined in terms of interpersonal influence, one would assume that they have their main projections on the interpersonal circumplex. In this study, the relations between leadership styles from the Multifactor Leadership Questionnaire and Leader Behaviour Description Questionnaire and both interpersonal and HEXACO personality scales are investigated. As expected, charismatic leadership and leader's consideration have strong projections on the interpersonal circumplex, with main projections on the warm-agreeable octant. Transactional leadership, passive leadership, and task-oriented leadership have considerably weaker or no projections on the circumplex. Leader's consideration is most strongly related to interpersonal personality while both transactional and passive leadership are most strongly related to non-interpersonal personality. It is concluded that especially charismatic leadership and leader's consideration are captured almost fully by the HEXACO pers.
The intergenerational transmission of domestic violence: the role that gender plays in attribution and consequent intimate partner violence

The intergenerational transmission of domestic violence has received significant research attention. In this study, a sample of 194 couples in Beijing was tested on the transmission mechanism. Thus, we asked: does marital attribution play a mediated role in the transmission from family-of-origin violence to subsequent intimate partner violence? We used three questionnaires: family-of-origin violence, Revised Conflict Tactics Scale (CTS2), and Marital Attitude Survey (MAS). Results showed that: (1) in family-of-origin violence, incidence of parent-to-child violence is much higher than inter-parental violence, in which incidence of father-to-mother violence is much higher than mother-to-father violence. (2) Family-of-origin violence has an impact on intimate partner violence (IPV); however, mothers’ perpetration of violence is more likely to have stronger effects. (3) Husbands’ attributions of malicious intent to spouse, and wives’ attributions of causality to spouse’s behavior can mediate parent-to-self violence and IPV. However, other types of dysfunctional marital attributions are not mediators in the relations between family-of-origin violence and IPV.
Compensation of observability problem in a multi-robot localization scenario using CEKF

Many localization techniques today rely on absolute landmark measurements to efficiently track the robot's position in space. Although absolute landmarks are essential for correctly estimating its position, they might be rare in an unknown environment. This means that the robot would have to traverse long distances without any outside reference point resulting in system degradation. In case of a robot team though, each robot can rely on both absolute or relative position measurements between robots. This paper describes an approach for a multi-robot localization system, based on a single centralized extended Kalman filter (CEKF) to track the position and orientation changes of a group of robots. Moreover, it is shown that if the robots in the group collect only relative measurements the system suffers from observability problem. It is proven that an increasing number of mobile robots capable of relative measurements only, reduces the observability problem and compensates for the need of external absolute landmarks thus providing efficient localization.
New method for determination complexity using in AD HOC cloud computing

The paper present new method for determination complexity of using in new hyper-hybrid AD HOC cloud computing. A large body of research has been devoted to identifying the complexity of structures in networks. The study of complex networks is a young and active area of scientific research inspired largely by the empirical study of real-world networks such as computer networks and social networks. Networks are a ubiquitous way to represent complex systems, including those in the social and economic sciences. Understanding complexity and broad systems-level frameworks in the life, physical and social sciences has turned, in recent decades, to issues of network dynamics. It has been shown that many real complex networks share distinctive characteristic properties that differ in many ways from the random and regular networks. We present some challenges problem of AD HOC network. In this paper we introduce a new method for quantifying the complexity of a new hyper hybrid AD HOC cloud network based on presenting the nodes of the network in Cartesian coordinates, converting to polar coordinates, and calculating the fractal dimension. Our results suggest that this approach can be used to determine the complexity for any type of network.
Two-Dimensional DoA Estimation for Multipath Propagation Characterization Using the Array Response of PN-Sequences

Multipath propagation and power arrival profiles in three-dimensional (3-D) space determine the performance of the full-dimensional MIMO (FD-MIMO) systems. Field channel measurements are crucial in characterizing wireless channel properties. Nevertheless, in spatial channel measurements, estimating the direction-of-arrivals (DoAs) of multipath components (MPCs) is a challenging issue, because of the large number of propagation paths and the correlation among the multipath signals. The number of incidence angles and estimation precision in traditional methods is limited by the sensor array size and signal correlation. In this paper, we propose a scheme for measuring and estimating the 2-D DoAs of propagation paths called multipath angular estimation using the array response of PN-sequences (MAPS). By using a receiving planar antenna array (PAA), MAPS first extracts the complex path array response vector (PARV) for each propagation path and then estimates the DoAs of the paths individually and independently. The subspace-decomposition theory for MAPS is proved and extensive simulations are conducted to compare MAPS with other algorithms. Furthermore, a channel sounder using two PAAs and the probing signal of 2.6 GHz carrier modulated by PN-sequences has been developed. The simulation and field tests show that MAPS can estimate arbitrary number of resolved MPCs in a channel snapshot and effectively suppress the multipath interference.
A Program to Promote Moral Development through Elementary School Physical Education

This study examined the effectiveness of a specially designed physical education program on the moral development of elementary-age students. Two fifth-grade physical education classes (N = 32) served as control and experimental groups, and participated in identical physical activities during an 8-week program. The experimental group was exposed to special teaching strategies designed to foster moral growth whereas the control group was not. Moral reasoning data were gathered using pre- and posttest interviews. A test of homogeneity of variances on pretest scores revealed that the two intact classes were equivalent on the pretest moral measures. Consequently, a t test was appropriately employed to compare gain scores between the experimental and control groups. T test analyses on the moral reasoning gain scores showed significant differences between the groups in moral growth, with the experimental group showing greater improvement in sport, life, and overall moral reasoning. T tests conducted on within-g.
Language Planning and Language Revival

This paper explores the interface between language planning and language revival, based on current efforts to reclaim and reintroduce Kaurna, the language of the Adelaide Plains. This language probably had not been used on a daily basis for the best part of 130 years, until recent efforts in the 1990s to revive it. Using written records, efforts are now being made to piece the language together and to develop a written and spoken language that addresses contemporary needs. Micro language planning is salient in the revival context. Indeed, language planning in this context typically involves individual learners and users of the language, small groups and very small organisations. This paper extends the vision of language planners to include languages hitherto regarded as 'dead' or 'extinct'. Language planning has as much to offer in these situations as it does for major world languages.