Miracle-dz/UniFAR-FTUs huggingface dataset:
Muscle protein metabolism in female swimmers after a combination of resistance and endurance exercise.

There is little known about the responses of muscle protein metabolism in women to exercise. Furthermore, the effect of adding resistance training to an endurance training regimen on net protein anabolism has not been established in either men or women. The purpose of this study was to quantify the acute effects of combined swimming and resistance training on protein metabolism in female swimmers by the direct measurement of muscle protein synthesis and whole body protein degradation. Seven collegiate female swimmers were each studied on four separate occasions with a primed constant infusion of ring-[13C6]phenylalanine (Phe) to measure the fractional synthetic rate (FSR) of the posterior deltoid and whole body protein breakdown. Measurements were made over a 5-h period at rest and after each of three randomly ordered workouts: 1) 4,600 m of intense interval swimming (SW); 2) a whole body resistance-training workout with no swimming on that day (RW); and 3) swimming and resistance training combined (SR). Whole body protein breakdown was similar for all treatments (0.75 +/- 0.04, 0.69 +/- 0.03, 0.69 +/- 0.02, and 0.71 +/- 0.04 mumol.min-1.kg-1 for rest, RW, SW, and SR, respectively). The FSR of the posterior deltoid was significantly greater (P < 0.05) after SR (0.082 +/- 0.015%/h) than at rest (0.045 +/- 0.006%/h). There was no significant difference in the FSR after RW (0.048 +/- 0.004%/h) or SW (0.064 +/- 0.008%/h) from rest or from SR. These data indicate that the combination of swimming and resistance exercise stimulates net muscle protein synthesis above resting levels in female swimmers.
Gap Analysis and Conservation Network for Freshwater Wetlands in Central Yangtze Ecoregion

The Central Yangtze Ecoregion contains a large area of internationally important freshwater wetlands and supports a huge number of endangered waterbirds; however, these unique wetlands and the biodiversity they support are under the constant threats of human development pressures, and the prevailing conservation strategies generated based on the local scale cannot adequately be used as guidelines for ecoregion-based conservation initiatives for Central Yangtze at the broad scale. This paper aims at establishing and optimizing an ecological network for freshwater wetland conservation in the Central Yangtze Ecoregion based on large-scale gap analysis. A group of focal species and GIS-based extrapolation technique were employed to identify the potential habitats and conservation gaps, and the optimized conservation network was then established by combining existing protective system and identified conservation gaps. Our results show that only 23.49% of the potential habitats of the focal species have been included in the existing nature reserves in the Central Yangtze Ecoregion. To effectively conserve over 80% of the potential habitats for the focal species by optimizing the existing conservation network for the freshwater wetlands in Central Yangtze Ecoregion, it is necessary to establish new wetland nature reserves in 22 county units across Hubei, Anhui, and Jiangxi provinces.
Experiences and observations on the industrial implementation of a system to search over outsourced encrypted data

This paper presents an industrial report on the implementation of a system that supports execution of queries over encrypted data. While this idea is not new, e.g. [HILM02, AKRX04, PRZB11], the implementation in a real world large scale in-memory database is still challenging. We will provide an overview of our architecture and detail two use cases to give the reader an insight into how we technically realized the implementation. We then provide three main contributions, reporting that: a) We significantly improve functionality by intelligently splitting query execution, i.e. which parts of a query can be performed in the cloud and which on the client. b) We share some initial performance measurements with the community on basis of the TPCH benchmark. c) We present a domain-specific analysis of three data sets that shows the effects of executing queries over encrypted data and what adjustments are required with respect to the encryption of individual columns. The three made observations on query execution, execution time measurements and domain-specific query analysis will lead us to the conclusion that although searching over outsourced encrypted data is always a trade off between functionality, performance and security, it is realistic to assume that working solutions can be provided in the not too distant future to the market.
Invasive pneumococcal disease among adults: associations among serotypes, disease characteristics, and outcome.

BACKGROUND The Streptococcus pneumoniae polysaccharide capsule may be related to invasive pneumococcal disease (IPD) course. METHODS We performed a retrospective cohort study with nationally representative surveillance data from 1075 hospitalized patients with IPD from the Netherlands from 1 June 2004 through 31 May 2006 in the prevaccination era. Serotypes were grouped according to invasive disease potential, rate of the most serious clinical syndromes of meningitis and bacteremia without focus, and case-fatality rates. Multivariable logistic regression analysis was performed to obtain odds ratios adjusted for baseline confounders for the association of serotypes and these outcomes, using the serotypes with the lowest rates as reference. RESULTS IPD caused by serogroups with low invasive disease potential concerned meningitis or bacteremia without focus in 22% of cases, and 74% of patients had an underlying comorbidity. For highly invasive serogroups these figures were 10% (P < .01) and 56% (P < .01). Individual serotypes varied in the relative rate by which they caused meningitis or bacteremia without focus. Compared with the reference group composed of serotypes 1, 5, 7F, 15B, 20, and 33F, the group of serotypes 3, 19F, 23A, 16F, 6B, 9N, and 18C was associated with increased case-fatality rates (group adjusted odds ratio, 2.6; 95% confidence interval, 1.5-4.7). CONCLUSIONS The serotype appeared to be independently associated with IPD severity in adults, which indicates that careful monitoring of IPD after implementation of conjugate vaccines is necessary.
An Approach to Detection of High Impedance Fault Using Discrete Wavelet Transform and Artificial Neural Networks

High impedance faults (HIF) are faults that are difficult to detect by conventional protection relays. In this paper, a new HIF model is introduced and a novel methodology is presented to detect HIF by means of discrete wavelet transform (DWT) and artificial neural network (ANN). The distorted waveforms (HIF, load switching, line switching, capacitor switching and non-linear loads that behave similar to HIF current) are generated using PSCAD/EMTDC, captured with a sampling rate of 20 kHz and de-noised using DWT to obtain signals with higher signal-to-noise ratio. DWT is used to decompose the distorted signal and to extract its useful information. Appropriate feature vectors are created and applied in training the ANN. The effectiveness of the proposed method was tested using a wide spectrum of disturbances. Simulations are carried out to confirm the suitability and capability of the proposed method in HIF detection.
Religious coping strategies and spiritual transcendence

People use both positive and negative religious coping strategies, and do so in the context of how they perceive their relationship with God, which means that both require individuals to acquire some degree of self transcendence. This study attempted to show that self transcendence is incorporated in both positive and negative coping strategies. The sample consisted of 190 practising Anglicans and Catholics. They completed RCOPE from which two variables measuring positive coping and negative coping were then constructed, the Self Transcendence Scale (ST) the item content of which is largely positive and the Spiritual Transcendence Scale (STS) of the Temperament and Character Inventory, which acknowledges negative as well as positive experiences. They also completed a scale, God Cares, measuring a person's perception of God as caring. In a series of hierarchical regression analyses, all three variables, the perception of God as caring, and both the positive and negative coping variables predicted ST and all of its subscales except one. The positive coping variable largely predicted STS, the perception of God as caring variable less so and the negative coping variable not at all. The findings were interpreted as suggesting that both perceiving God as caring and using positive coping strategies limit the problematic feelings associated with negative coping strategies, allowing the self transcendence implicit in them to appear.
Resilience among very old men and women

High resilience is characterised by qualities of equanimity, perseverance, self-reliance, meaningfulness and existential aloneness. The aims of the present study were both to explore how the oldest of old men and women with estimated high resilience talk about experiences of becoming and being old, and to discuss the analysis of their narratives in terms of the foundational concepts of the Resilience Scale (RS). Thematic narrative interviews collected from 24 old people were analysed using content analysis, and the following themes were identified: feeling connected, feeling independent and creating meaning. The themes can be seen as congruent with the underlying concepts of the Resilience Scale; however, the themes were markedly gendered. A combination of both quantitative and qualitative research may contribute to a new angle of approach towards our understanding of resilience. In nursing practice it is of importance to both stimulate social contacts in the present and listen to narratives from the past to increase resilience among the oldest patients.
Pragmatic Language Intervention for Children with Language and Emotional/Behavioral Disorders

Children diagnosed with emotional/behavioral disorders experience expressive and pragmatic language disorders that can negatively affect educational success. This article describes a classroom-based pragmatic language intervention program that was conducted with children diagnosed as having an emotional/ behavioral disorder. Results of the program suggested that the classroom-based pragmatic language intervention may have positively influenced the ability of the participants to employ pragmatic skills, such as providing sufficient and detailed information, stating opinions, and using verbal language to negotiate with others.
The people make the process: commitment to employees, decision making, and performance

This study argues that a well designed decision making process will have its most positive impact on company financial performance when it is carried out by a capable, motivated and dedicated workforce. Prior research has determined that such a workforce can be developed via an organization’s commitment to its employees (OCE) in the form of ample training and compensation, fairness, and meaningful personal consideration. We argue that OCE will enhance financial performance where it is able to improve the quality of a decision making process that emphasizes ample information processing, collaboration, and initiative. Conversely, these three dimensions of decision making are expected to be of little value where OCE—and hence a capable and motivated workforce—are lacking. These expectations were borne out in our study of Korean companies. Specifically, we found positive associations between return on assets and the interactions between OCE and information processing, collaboration, and initiative, respectively. We found also that these interactions contributed the most to return on assets in uncertain environments, where effective information processing, collaboration and initiative were especially important.
English Light Verb Construction Identification Using Lexical Knowledge

This research describes the development of a supervised classifier of English light verb constructions, for example, "take a walk" and "make a speech. " This classifier relies on features from dependency parses, OntoNotes sense tags, WordNet hypernyms and WordNet lexical file information. Evaluation shows that this system achieves an 89% F1 score (four points above the state of the art) on the BNC test set used by Tu & Roth (2011), and an F1 score of 80.68 on the OntoNotes test set, which is significantly more challenging. We attribute the superior F1 score to the use of our rich linguistic features, including the use of WordNet synset and hypernym relations for the detection of previously unattested light verb constructions. We describe the classifier and its features, as well as the characteristics of the OntoNotes light verb construction test set, which relies on linguistically motivated PropBank annotation.
The Acute Antihyperalgesic Action of Nonsteroidal, Anti-Inflammatory Drugs and Release of Spinal Prostaglandin E2 Is Mediated by the Inhibition of Constitutive Spinal Cyclooxygenase-2 (COX-2) but not COX-1

Western blots show the constitutive expression of COX-1 and COX-2 in the rat spinal dorsal and ventral horns and in the dorsal root ganglia. Using selective inhibitors of cyclooxygenase (COX) isozymes, we show that in rats with chronic indwelling intrathecal catheters the acute thermal hyperalgesia evoked by the spinal delivery of substance P (SP; 20 nmol) or NMDA (2 nmol) and the thermal hyperalgesia induced by the injection of carrageenan into the paw are suppressed by intrathecal and systemic COX-2 inhibitors. The intrathecal effects are dose-dependent and stereospecific. In contrast, a COX-1 inhibitor given systemically, but not spinally, reduced carrageenan-evoked thermal hyperalgesia but had no effect by any route with spinal SP hyperalgesia. Using intrathecal loop dialysis catheters, we showed that intrathecal SP would enhance the release of prostaglandin E2 (PGE2). This intrathecally evoked release of spinal PGE2 was diminished by systemic delivery of nonspecific COX and COX-2-selective inhibitors, but not a COX-1-selective inhibitor. Given at systemic doses that block SP- and carrageenan-evoked hyperalgesia, COX-2, but not COX-1, inhibitors reduced spinal SP-evoked PGE2 release. Thus, constitutive spinal COX-2, but not COX-1, is an important contributor to the acute antihyperalgesic effects of spinal as well as systemic COX-2 inhibitors.
Online, GA based mixture of experts: a probabilistic model of ucs

In recent years there have been efforts to develop a probabilistic framework to explain the workings of a Learning Classifier System. This direction of research has met with limited success due to the intractability of complicated heuristic training rules used by the learning classifier systems. In this paper, we derive a learning classifier system from a mixture of experts that is similar to a sUpervised Classifier System (UCS) in terms of its training and prediction routines. We start by framing the learning model as a mixture of experts which uses an Expectation Maximisation (EM) procedure to learn its parameters. The batch updates of the EM is then converted into online updates and finally into a GA based sampled online update thus ending up with a classifier system similar to a sUpervised Classifier System. In this paper, we show the effectiveness of such a system as compared to UCS through a series of comparative studies on test datasets.
Communication Complexity of Combinatorial Auctions with Submodular Valuations

We prove the first communication complexity lower bound for constant-factor approximation of the submodular welfare problem. More precisely, we show that a (1−1/2e+e)-approximation (b 0.816) for welfare maximization in combinatorial auctions with submodular valuations would require exponential communication. We also show NP-hardness of (1−1/2e+e)-approximation in a computational model where each valuation is given explicitly by a table of constant size. Both results rule out better than (1−1/2e)-approximations in every oracle model with a separate oracle for each player, such as the demand oracle model. Our main tool is a new construction of monotone submodular functions that we call multi-peak submodular functions. Roughly speaking, given a family of sets F, we construct a monotone submodular function f with a high value f(S) for every set S e F (a "peak"), and a low value on every set that does not intersect significantly any set in F. We also study two other related problems: max-min allocation (for which we also get hardness of (1-1/2e+e)-approximation, in both models), and combinatorial public projects (for which we prove hardness of (3/4 + e)-approximation in the communication model, and hardness of (1−1 + e)-approximation in the computational model, using constant size valuations).
Spatio-temporal variation in the preservation of ancient faunal remains

Palaeodemographic studies of animals using frequency distributions of radiocarbon dates are increasingly used in studies of Quaternary extinction but are complicated by taphonomic bias, or the loss of material through time. Current taphonomic models are based on the temporal frequency distributions of sediments, but bone is potentially lost at greater rates because not all sedimentary contexts preserve bone. We test the hypotheses that (i) the loss of bone over time is greater than that of sediment and (ii) this rate of loss varies geographically at large scales. We compiled radiocarbon dates on Pleistocene-aged bone from eastern Beringia (EB), the contiguous United States (CUSA) and South America (SA), from which we developed models of taphonomic loss. We find that bone is lost at greater rates than terrestrial sediment in general, but only for CUSA and SA. Bone in EB is lost at approximately the same rate as terrestrial sediments, which demonstrates the excellent preservation environments of arctic regions, presumably due to preservative effects of permafrost. These differences between bone and sediment preservation as well as between arctic and non-arctic regions should be taken into account by any research addressing past faunal population dynamics based on temporal frequency distributions.
The evolution of type 1 active galactic nuclei in the infrared (15 μm): the view from ELAIS‐S1

We present the 15-mum luminosity function of type 1 active galactic nuclei (AGN1; quasi-stellar object+Seyfert 1) . Our sample of 21 high-redshift sources is selected from the Preliminary Analysis catalogue in the S1 field of the European Large Area ISO Survey (ELAIS). To study the cosmological evolution of the AGN1 luminosity function, our sample has been combined with a local sample of 41 sources observed by IRAS . We find that the luminosity function of AGN1 at 15mum is fairly well represented by a double-power-law-function. There is evidence for significant cosmological evolution consistent with a pure luminosity evolution (PLE) model L (z )~(1+z ) k L , with k L =3.0-3.3. The value of k L depends on the existence or non-existence of an evolution cut-off at redshift ~2, and on the adopted cosmology. From the luminosity function and its evolution we estimate a contribution of AGN1 to the cosmic infrared background (CIRB) of nuI nu ~6×10-11 Wm-2 sr-1 at 15mum. This corresponds to ~2-3 per cent of the total observed CIRB at this wavelength. Under the usual assumptions of unified models for AGN, the expected contribution of the whole AGN population to the CIRB at 15mum is 10-15 per cent.
Coupling of antibodies via protein Z on modified polyoma virus‐like particles

Therapeutic application of virus‐based delivery systems often implies a change of the tropism of these vectors. This can be achieved by insertion of polypeptides (e.g., antibody fragments) in viral coat proteins. Such fusion proteins have only been used in viral vectors so far and, as part of a virus, they have not been available for a detailed biophysical characterization. We analyzed a fusion protein called VP1‐Z, which is based on the polyoma virus coat protein VP1 and protein Z. Protein Z is an engineered antibody‐binding domain derived from protein A from Staphylococcus aureus. The fusion VP1‐Z was constructed by insertion of protein Z in the HI‐loop of VP1. As wild‐type VP1, VP1‐Z formed pentameric capsomers and assembled to VLPs in vitro. The stability of these particles was very similar compared to that of VLPs of wild‐type VP1. Protein Z was fully structured in the fusion protein and was still capable of binding antibodies on the surface of VLPs of VP1‐Z. Using this fusion protein, we could change the tropism of polyoma VLPs toward cells presenting on their surface the antigen of the coupled antibody.
Evaluation of Moxifloxacin, a New 8-Methoxyquinolone, for Treatment of Meningitis Caused by a PenicillinResistant Pneumococcus in Rabbits

ABSTRACT Moxifloxacin is a new 8-methoxyquinolone with high activity against gram-positive bacteria, including penicillin-resistant pneumococci. In an experimental meningitis model, we studied the pharmacokinetics of moxifloxacin in infected and uninfected rabbits and evaluated the antibiotic efficacies of moxifloxacin, ceftriaxone, and vancomycin against a penicillin-resistantStreptococcus pneumoniae strain (penicillin, ceftriaxone, vancomycin, and moxifloxacin MICs were 1, 0.5, 0.5, and 0.125 μg/ml, respectively). Moxifloxacin entered cerebrospinal fluid (CSF) readily, with peak values within 15 to 30 min after bolus intravenous infusion and with a mean percent penetration into normal and purulent CSF of approximately 50 and 80%, respectively. The bactericidal effect of moxifloxacin was concentration dependent, and regrowth was seen only when the concentration of moxifloxacin in CSF was below the minimal bactericidal concentration. All antibiotic-treated groups (moxifloxacin given in two doses of 40 mg/kg of body weight, moxifloxacin in two 20-mg/kg doses, ceftriaxone in one 125-mg/kg dose, and vancomycin in two 20-mg/kg doses) had significantly higher reductions in CSF bacterial concentration than the untreated group (P < 0.05). Moxifloxacin was as effective as vancomycin and ceftriaxone in reducing bacterial counts at all time points tested (3, 5, 10, and 24 h). Moreover, moxifloxacin given in two 40-mg/kg doses resulted in a significantly higher reduction in CSF bacterial concentration (in log10 CFU per milliliter) than vancomycin within 3 h after the start of antibiotic treatment (3.49 [2.94 to 4.78] versus 2.50 [0.30 to 3.05]; P < 0.05). These results indicate that moxifloxacin could be useful in the treatment of meningitis, including penicillin-resistant pneumococcal meningitis.
On the performance of randomized communication topologies for rendezvous control of multiple vehicles

—In this paper we analyze randomized coordination control strategies for the rendezvous problem of multiple agents with unknown initial positions. The performance of these control strategies is measured in terms of three important metrics: average relative agents’ distance, total input energy consumption, and number of packets per unit time that each agent can receive from the other agents. By adopting an LQ-like optimal control approach, we show how to numerically compute optimal feedback gains for randomized communication topologies. In particular we show that there is a trade off between these three metrics and that the optimal feedback is a sum of two terms: one that depends only the on agents own positions and the other that depends only on relative distances between agents.