Miracle-dz/UniFAR-FTUs huggingface dataset:
(η6-Benzene)(carbonato-κ2 O,O′)[dicyclohexyl(naphthalen-1-ylmethyl)phosphane-κP]ruthenium(II) chloroform trisolvate

The title compound, [Ru(CO3)(η6-C6H6){(C6H11)2P(CH2C10H7)}]·3CHCl3, was synthesized by carbonation of [RuCl2(η6-C6H6){(C6H11)2P(CH2C10H7)}] with NaHCO3 in methanol at room temperature. The RuII atom is surrounded by a benzene ligand, a chelating carbonate group and a phosphane ligand in a piano-stool configuration. The crystal packing is consolidated by C—H⋯O and C—H⋯Cl hydrogen-bonding interactions between adjacent metal complexes and between the complexes and the solvent molecules. The asymmetric unit contains one metal complex and three chloroform solvent molecules of which only one was modelled. The estimated diffraction contributions of the other two strongly disordered chloroform solvent molecules were substracted from the observed diffraction data using the SQUEEZE procedure in PLATON [Spek (2009 ▶). Acta Cryst. D65, 148–155].
Simplification of a Locus-Specific DNA Typing Method (Vir Typing) for Streptococcus pyogenes

ABSTRACT We describe a simplification of a highly discriminatory molecular typing method, called Vir typing, for Streptococcus pyogenes (D. Gardiner, J. Hartas, B. Currie, J. D. Mathews, D. J. Kemp, and K. S. Sriprakash, PCR Methods Appl. 4:288–293, 1995). The procedure can be completed within a day, is reproducible, and can be applied directly to colonies growing on primary culture plates, allowing rapid establishment of strain identity in an outbreak.
Energy-Efficient Power Allocation for Distributed Antenna Systems With Proportional Fairness

In this paper, we propose an energy-efficient power allocation scheme for the downlink multiuser distributed antenna systems. The objective is to maximize the energy efficiency (EE) under the constraints on per-antenna transmit power and proportional data rates among users. Since EE function is typically defined in fractional form, it is computationally complex to optimize the EE directly. We first convert the nonlinear fractional problem into an equivalent but better tractable problem, based on which we derive an iterative algorithm to obtain the global optimum of the considered problem. On top of being optimal, the solution is also lightweight since only a single-variable nonlinear equation needs to be solved. Furthermore, we can flexibly switch to another mode of operation which delivers relatively higher spectral efficiency (SE) at the expense of losing EE. Numerical simulations and complexity analysis validate that the proposed scheme achieves much higher SE and EE performance with stricter satisfaction of the proportional rate constraints and lower complexity, compared to the state-of-the-art scheme in literature.
Comparison of Batch Scheduling for Identical Multi-Tasks Jobs on Heterogeneous Platforms

In this paper we consider the scheduling of a batch of the same job on a heterogeneous execution platform. A job is represented by a directed acyclic graph without forks (intree) but with typed tasks. The execution resources are distributed and each resource can carry out a set of task types. The objective function is to minimize the makespan of the batch execution. Three algorithms are studied in this context: an online algorithm, a genetic algorithm and a steady-state algorithm. The contribution of this paper is on the experimental analysis of these algorithms and on their adaptation to the context. We show that their performances depend on the size of the batch and on the characteristics of the execution platform.
Cognitive Defenses and Life Stress: An Information-Processing Analysis

Lazarus proposed that defensive behaviors may be detrimental to long-term stress management to the extent that they interfere with direct stress-coping strategies. Two studies considered this proposal for four cognitive defenses—projection, repression, rationalization, and denial—as well as the role of internal scanning as a moderator variable. Projection and denial were positively related to stress level over a 1-yr. period supporting the Lazarus view, but rationalization was inversely related. More specific effects considering breadth of scanning demonstrated all three defenses that function by evasion of information (projection, repression, and denial) showed positive relations with stress for narrow scanners but not for broad scanners. Rationalization presented the opposite pattern. Subjects combining rationalization with broad scanning were uniquely free of stress. An interpretation of these findings was proposed bearing upon the amount of information available to individuals regarding stressors that might influence direct strategies for reduction of stress.
Change leaders and change managers: different or complementary?

The role of “change leaders” in initiating or sponsoring strategic change in organisations is often positively presented as the counter‐image of traditional managerial roles. Managers, and especially middle managers, are viewed as individuals lacking in the, apparently, proactive attributes of flexibility, risk‐taking and openness to new ideas essential for creating or managing change. However, there have been few attempts to clarify these counter‐images, or the extent to which the roles of leading and managing change may in fact be complementary. The research presented here uses a Delphi‐style panel of ten change agent experts to identify and rank the sets of “attributes” they perceive to characterise the roles of leading and managing change. The findings suggest that the attributes of the two roles are different, yet complementary. It is concluded that the distinction between “change leaders” and “change managers” may be useful in clarifying the nature of the relationship between leadership and management in processes of organisational change.
Biometric Evaluation on the Cloud: A Case Study with HumanID Gait Challenge

Biometric datasets are growing in size with time. Procurement of such datasets and resources for development and evaluation of biometric algorithms is expensive, time consuming and often requires expertise in systems software. Our goal in this project is to build a cloud-based evaluation system, which can host a common dataset and allow the submission of algorithms either as source code or Linux x-86 executable, to enforce a standard experimental protocol, and to provide results in a standard format. This facilitates comparing algorithms with each other and benchmarking progress. In order to efficiently service these algorithms, we need expensive computers with lot of storage and processing power. Having such systems eliminates the need for procurement of datasets and resources for experimentation, thus lowering the barrier for engaging in biometrics research. This style of cloud-based online evaluation system will encourage other biometric and research communities to build similar systems. The preferred solution to deploy this web-app is using Amazon Web Services, which provides computing power as well as storage capacity. In this paper, we share our experience with transitioning the HumanID Gait Challenge from traditional data+code type structure to a cloud based solution. It is available at http://marathon.csee. usf.edu/GaitBaseline/gaitcloud.
Platelet Thromboxane A2 Secretion in Patients With Major Depression Responsive to Electroconvulsive Therapy

Objective: To determine a) whether clinical response to electroconvulsive therapy (ECT) is associated with decreased platelet activation in patients with major depressive disorder (MDD) and b) if any medical/demographic characteristics predict response to ECT or changes in platelet activation. Increased platelet activation may underlie the increased risk of coronary artery disease (CAD) in patients with MDD. Methods: Before their first and sixth ECT treatments, study patients (n = 44) completed the Beck Depression Inventory (BDI) to assess the severity of depressive symptoms. Activity of the platelet thromboxane (TBX) A2 pathway was assessed by measuring the morning spot urinary concentrations of 11-dehydroxy-thromboxane B2 (11-D-TBX B2), a major metabolite of platelet-derived TBX A2. Results: Multivariate logistic regression analyses revealed that improvement on the BDI was significantly more likely in patients without a history of hypertension (p = .02) and in patients who were prescribed a greater number of “platelet-altering” medications (p = .03). During a course of ECT, a decrease in urinary 11-D-TBX B2 was significantly more likely to occur in ECT nonresponders (p = .01) and younger patients (p = .02). Conclusions: Clinical response to ECT coadministered may not be associated with decreases in platelet-derived TBX. Future studies will confirm which somatic “antidepression” treatments offer optimal thrombovascular benefits for depressed patients with multiple risk factors for, or clinically evident, cerebral disease or CAD. 5HT = serotonin; 11-D-TBX B2 = 11-dehydroxy-thromboxane B2; ASA = aspirin; BDI = Beck Depression Inventory; CAD = coronary artery disease; ECG = electrocardiogram; ECT = electroconvulsive therapy; ECT-1 = first ECT; ECT-6 = sixth ECT; ELISA = enzyme-linked immunosorbent assay; GPIIb/IIIa = glycoprotein IIb/IIIa; TBX = thromboxane; MDD = major depressive disorder; MI = myocardial infarction; SSRIs = selective serotonin reuptake inhibitors.
Linking Family Economic Hardship to Adolescent Distress

A study of 451 families living in the rural Midwest examined the negative impact of financial problems on early adolescents' symptoms of psychological distress. The tested model links financial difficulties to adolescent psychological problems through the quality of marital and parent-child relationships. Results show that economic stress has a direct effect on marital quality which, in turn, disrupts or undermines the parent-child relationship. Negative feelings by parents and adolescents about their relationships tend to increase adolescent psychological distress. This general model operates similarly across four family dyads: fathers and sons, fathers and daughters, mothers and sons, and mothers and daughters. Overall, the diminished quality of marital and parent-child relationships represents one pathway by which economic hardship places adolescents at risk for psychological dysfunction.
Brief communication: a sample of pediatric skulls available for study.

Les AA. presentent brievement une collection de crânes articules juveniles modernes avec les mandibules, conservee a la Johns Hopkins University (Baltimore, Maryland, Etats-Unis), et disponible depuis peu pour la recherche. Cette collection, unique en son genre, referenciee d'apres le nom du Docteur James F. Bosma qui l'a constituee a partir des annees 1950, comprend sept crânes de nouveaux-nes et vingt-trois autres crânes d'enfants, du nourrisson a l'adolescent. Les AA. ont catalogue la dentition, les pathologies osseuses et dentaires, ainsi que les coordonnees tri-dimensionnelles de la structure des crânes.
EHadoop: Network I/O Aware Scheduler for Elastic MapReduce Cluster

Over the last few years the usage of cloud computing dramatically increased. Many data analytics platforms run on the cloud. Such systems characterized by large data transfer among VMs. The network isolation between cloud users in modern data centers is not as good as CPU and memory isolation [20]. The weak isolation leads to unpredictable performance of the inter data center network. Moreover, with the raise of popularity of cloud computing the competition between providers get tougher, which leads to prices decrease. Some users decide to perform data-analytics in a cross-cloud fashion [11], which requires data transfer over WAN. It is known that WAN provides lower than LAN performance. We show that saturated network can greatly impact MapReduce job's task completion time. It results in higher costs for the user, because according to the pay-as-you-go model the user pays for the time resources being used. In this work we present EHadoop network I/O aware scheduler for elastic MapReduce cluster which performs online job profiling and schedules tasks based on available network bandwidth. The evaluation results show that EHadoop allows to avoid network contention and does not increase MapReduce task completion time with network bandwidth degradation.
Electroporation Knows No Boundaries

The discovery of RNA interference (RNAi) has enabled several breakthrough discoveries in the area of functional genomics. The RNAi technology has emerged as one of the major tools for drug target identification and has been steadily improved to allow gene manipulation in cell lines, tissues, and whole organisms. One of the major hurdles for the use of RNAi in high-throughput screening has been delivery to cells and tissues. Some cell types are refractory to high-efficiency transfection with standard methods such as lipofection or calcium phosphate precipitation and require different means. Electroporation is a powerful and versatile method for delivery of RNA, DNA, peptides, and small molecules into cell lines and primary cells, as well as whole tissues and organisms. Of particular interest is the use of electroporation for delivery of small interfering RNA oligonucleotides and clustered regularly interspaced short palindromic repeats/Cas9 plasmid vectors in high-throughput screening and for therapeutic applications. Here, we will review the use of electroporation in high-throughput screening in cell lines and tissues.
Minimum Wage Shocks, Employment Flows, and Labor Market Frictions

We provide the first estimates of the effects of minimum wages on employment flows in the US labor market, identifying the impact by using policy discontinuities at state borders. We find that minimum wages have a sizable negative effect on employment flows but not on stocks. Separations and accessions fall among affected workers, especially those with low tenure. We do not find changes in the duration of nonemployment for separations or hires. This evidence is consistent with search models with endogenous separations.
Phytochemical and Cytotoxic Investigations of Curcuma mangga Rhizomes

Investigations on the cytotoxic effects of the crude methanol and fractionated extracts (hexane, ethyl acetate) C. mangga against six human cancer cell lines, namely the hormone-dependent breast cell line (MCF-7), nasopharyngeal epidermoid cell line (KB), lung cell line (A549), cervical cell line (Ca Ski), colon cell lines (HCT 116 and HT-29), and one non-cancer human fibroblast cell line (MRC-5) were conducted using an in-vitro neutral red cytotoxicity assay. The crude methanol and fractionated extracts (hexane and ethyl acetate) displayed good cytotoxic effects against MCF-7, KB, A549, Ca Ski and HT-29 cell lines, but exerted no damage on the MRC-5 line. Chemical investigation from the hexane and ethyl acetate fractions resulted in the isolation of seven pure compounds, namely (E)-labda-8(17),12-dien-15,16-dial (1), (E)-15,16-bisnor-labda-8(17),11-dien-13-on (2), zerumin A (3), β-sitosterol, curcumin, demethoxycurcumin and bis-demethoxycurcumin. Compounds 1 and 3 exhibited high cytotoxic effects against all six selected cancer cell lines, while compounds 2 showed no anti-proliferative activity on the tested cell lines. Compound 1 also demonstrated strong cytotoxicity against the normal cell line MRC-5. This paper reports for the first time the cytotoxic activities of C. mangga extracts on KB, A549, Ca Ski, HT-29 and MRC-5, and the occurrence of compound 2 and 3 in C. mangga.
Transcriptional Profiling of Whole Blood Identifies a Unique 5-Gene Signature for Myelofibrosis and Imminent Myelofibrosis Transformation

Identifying a distinct gene signature for myelofibrosis may yield novel information of the genes, which are responsible for progression of essential thrombocythemia and polycythemia vera towards myelofibrosis. We aimed at identifying a simple gene signature – composed of a few genes - which were selectively and highly deregulated in myelofibrosis patients. Gene expression microarray studies have been performed on whole blood from 69 patients with myeloproliferative neoplasms. Amongst the top-20 of the most upregulated genes in PMF compared to controls, we identified 5 genes (DEFA4, ELA2, OLFM4, CTSG, and AZU1), which were highly significantly deregulated in PMF only. None of these genes were significantly regulated in ET and PV patients. However, hierarchical cluster analysis showed that these genes were also highly expressed in a subset of patients with ET (n = 1) and PV (n = 4) transforming towards myelofibrosis and/or being featured by an aggressive phenotype. We have identified a simple 5-gene signature, which is uniquely and highly significantly deregulated in patients in transitional stages of ET and PV towards myelofibrosis and in patients with PMF only. Some of these genes are considered to be responsible for the derangement of bone marrow stroma in myelofibrosis. Accordingly, this gene-signature may reflect key processes in the pathogenesis and pathophysiology of myelofibrosis development.
Using Incomplete Information for Complete Weight Annotation of Road Networks

We are witnessing increasing interests in the effective use of road networks. For example, to enable effective vehicle routing, weighted-graph models of transportation networks are used, where the weight of an edge captures some cost associated with traversing the edge, e.g., greenhouse gas (GHG) emissions or travel time. It is a precondition to using a graph model for routing that all edges have weights. Weights that capture travel times and GHG emissions can be extracted from GPS trajectory data collected from the network. However, GPS trajectory data typically lack the coverage needed to assign weights to all edges. This paper formulates and addresses the problem of annotating all edges in a road network with travel cost based weights from a set of trips in the network that cover only a small fraction of the edges, each with an associated ground-truth travel cost. A general framework is proposed to solve the problem. Specifically, the problem is modeled as a regression problem and solved by minimizing a judiciously designed objective function that takes into account the topology of the road network. In particular, the use of weighted PageRank values of edges is explored for assigning appropriate weights to all edges, and the property of directional adjacency of edges is also taken into account to assign weights. Empirical studies with weights capturing travel time and GHG emissions on two road networks (Skagen, Denmark, and North Jutland, Denmark) offer insight into the design properties of the proposed techniques and offer evidence that the techniques are effective.
Lymphokine and nonlymphokine mRNA levels in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A

Northern and dot blotting with a panel of DNA probes were used to monitor the levels of specific mRNAs in mitogen-stimulated human T cells. The induction of IL-2 and IFN mRNAs required the synergistic action of PMA and either PHA or OKT3 mAb. In contrast, several nonlymphokine genes, the protooncogenes c-fos and c-myc, and the IL-2-R gene, were induced by either PHA or PMA alone. PHA increased the background levels of a 70 kD heat shock protein mRNA, but did not affect the observed background of c-myb mRNA. For all mRNAs that were induced, isolated CD4 and CD8 T cell subsets behaved similarly. Exogenous IL-2 had little (IFN) or no (IL-2) effect on lymphokine mRNAs, but significantly increased c-myc, IL-2-R and heat shock protein mRNAs. Therefore, the stimuli for lymphokine mRNAs differed from those required for several inducible nonlymphokine genes. IL-2 and IFN mRNAs exhibited some important similarities with c-myc, however. The levels of IL-2, IFN, and c-myc mRNA followed similar kinetics, peaking at 3 h in restimulated blasts and at 12 h in unstimulated T cells. The subsequent downregulation of lymphokine and c-myc mRNAs was retarded by cycloheximide. The induction of IL-2, IFN, and c-myc mRNAs was blocked by the immunosuppressive drug CsA, but not by the inactive analog CsH, and this block occurred at the level of nuclear transcription. Since the exogenous stimuli for lymphokine and c-myc gene expression differ, we suggest that intracellular controls must be shared to account for the similarities in their kinetics of expression and CsA sensitivity.
Computerized retrieval and classification: An application to reasons for late filings with the securities and exchange commission

This study explores a system to retrieve and classify the reasons for late mandatory SEC (Securities and Exchange Commission) filings. From the source documents, the system identifies the reasons for the late filing and classifies them into one or more of seven categories. The system can be used by potential investors who have to track a large number of filings concentrated within a day or two. Our results indicate that the SEC filings may be quite ambiguous, with experienced raters disagreeing on one category for a training sample of 600 filings in about 30% of the cases. However, allowing classifications into more than one category using document level information yields accuracy of about 90% in a test sample of 200 filings. We also show that the stock market reactions to over 9,000 late filings vary in an intuitive way according to the classified reasons.
Restless legs syndrome in pregnancy is a frequent disorder with a good prognosis

The aim of this study was to assess the prevalence of restless legs syndrome in pregnancy. We distributed a questionnaire to 541 consecutive postpartum patients and received answers from 251 (46%) women. Of the participants, 34% reported restless legs syndrome in pregnancy. In 97% of the women in whom restless legs syndrome had started during the pregnancy, the symptoms disappeared within two to three days after delivery. There was no correlation between pregnancy‐related restless legs syndrome and low hemoglobin levels in the first trimester, and the incidence of restless legs syndrome was not affected by use of iron supplementation. We conclude that in our population, restless legs syndrome in pregnancy is both frequent and transient, occurring in approximately one in three pregnancies and typically resolving within a few days after delivery.
Decoding Three-Dimensional Trajectory of Executed and Imagined Arm Movements From Electroencephalogram Signals

Decoding motor commands from noninvasively measured neural signals has become important in brain-computer interface (BCI) research. Applications of BCI include neurorehabilitation after stroke and control of limb prostheses. Until now, most studies have tested simple movement trajectories in two dimensions by using constant velocity profiles. However, most real-world scenarios require much more complex movement trajectories and velocity profiles. In this study, we decoded motor commands in three dimensions from electroencephalography (EEG) recordings while the subjects either executed or observed/imagined complex upper limb movement trajectories. We compared the accuracy of simple linear methods and nonlinear methods. In line with previous studies our results showed that linear decoders are an efficient and robust method for decoding motor commands. However, while we took the same precautions as previous studies to suppress eye-movement related EEG contamination, we found that subtracting residual electro-oculogram activity from the EEG data resulted in substantially lower motor decoding accuracy for linear decoders. This effect severely limits the transfer of previous results to practical applications in which neural activation is targeted. We observed that nonlinear methods showed no such drop in decoding performance. Our results demonstrate that eye-movement related contamination of brain signals constitutes a severe problem for decoding motor signals from EEG data. These results are important for developing accurate decoders of motor signal from neural signals for use with BCI-based neural prostheses and neurorehabilitation in real-world scenarios.