Miracle-dz/UniFAR-FTUs huggingface dataset:
Selecting a Timing Regime for On-Chip Networks

Either the presence or the absence of a global clock may be exploited in the design of an on-chip network. In the synchronous case, each router is able to consider a snapshot of global state and build a routing schedule with the knowledge that the system will proceed in a deterministic fashion. This enables a high degree of speculation to be supported, with the ability to make accurate predictions and handle any mispredictions at a low cost. In contrast, a clock-less or asynchronous approach distributes control decisions relying where possible only on local state to maximise fine-grain concurrency. Here it is the ability to generate and react to local control signals quickly that must be exploited rather than a reliance on global state. In this paper we compare and contrast the design of two on-chip networks: one exploiting delay-insensitive asynchronous control and the other implemented in a traditional synchronous design style.
Profi ling Genomes with Oligonucleotide Arrays

Th e exponential increase in available DNA sequence data, including completed genomes of plant, animal and insect model species, was accompanied by the development of a new technology that enables researchers to make full use of these data sets in their eff orts to decipher gene function. Th is DNA microarray technology can measure the relative abundance of tens of thousands of RNA transcripts in a given tissue or cell type in just one experiment. Th e resulting transcriptional profi les can then be used to elucidate how developmental processes are orchestrated as well as aid in prognosis and diagnosis of cancer and in the development of new drug targets. An Aff ymetrix GeneChip system for the analysis of oligonucleotide arrays has been installed in the Aff ymetrix Core Facility of the Instituto Gulbenkian de Ciência in Oeiras. As part of the Laboratório Associado the Core Facility functions as a service provider for gene expression analyses to the research community in Portugal. In a recent study, we have used GeneChips representing more than 8200 genes from the model plant Arabidopsis thaliana to identify genes with potential importance for pollen germination, pollen tube growth and pollen morphogenesis.
Biomarker system for studying muscle, stem cells, and cancer in vivo

Bioluminescent reporter genes are sensitive in situ tools for following disease progression in preclinical models, albeit they are subject to scattering and absorption in deep tissues. We have generated a bicistronic Cre/LoxP reporter mouse line that pairs the expression of firefly luciferase with quantifiable expression of a human placental alkaline phosphatase that is secreted into the serum (SeAP). With the use of this dual‐modality bioreporter with a novel, inducible Pax7‐ CreER line for tracking muscle satellite cells, we demonstrate the longitudinal kinetics of muscle stem cell turnover, accounting for a doubling of the signal from satellite cell and progeny every 3.93 wk in the transition from adolescence to early adulthood. We also show that this dual‐modality bioreporter can be incorporated in preclinical cancer models, whereby SeAP activity is reflective of tumor burden. Thus, this dual bioreporter permits both spatial localization and accurate quantification of biological processes in vivo even when the tissue of interest is deep within the animal. — Nishijo, K. ,Hosoyama, T. , Bjornson, C. R. R. , Schaffer, B. S. , Prajapati, S. I. , Bahadur, A. N. , Hansen, M. S. , Blandford, M. C. , McCleish, A. T. , Rubin, B. P., Epstein, J. A. , Rando, T. A. , Capecchi, M. R. , Keller, C. Biomarker system for studying muscle, stem cells, and cancer in vivo. FASEB J. 23, 2681–2690 (2009)
Technology facilitated coercive control: domestic violence and the competing roles of digital media platforms

Abstract This article describes domestic violence as a key context of online misogyny, foregrounding the role of digital media in mediating, coordinating, and regulating it; and proposing an agenda for future research. Scholars and anti-violence advocates have documented the ways digital media exacerbate existing patterns of gendered violence and introduce new modes of abuse, a trend highlighted by this special issue. We propose the term “technology facilitated coercive control” (TFCC) to encompass the technological and relational aspects of patterns of abuse against intimate partners. Our definition of TFCC is grounded in the understanding of domestic violence (DV) as coercive, controlling, and profoundly contextualised in relationship dynamics, cultural norms, and structural inequality. We situate TFCC within the multiple affordances and modes of governance of digital media platforms for amplifying and ameliorating abuse. In addition to investigating TFCC, scholars are beginning to document the ways platforms can engender counter-misogynistic discourse, and are powerful actors for positive change via the regulation and governance of online abuse. Accordingly, we propose four key directions for a TFCC research agenda that recognises and asks new questions about the role of digital media platforms as both facilitators of abuse and potential partners in TFCC prevention and intervention.
A Novel Technique for Fingerprint Classification Based on Fuzzy C-Means and Naive Bayes Classifier

Fingerprint classification is a key issue in automatic fingerprint identification systems. One of the main goals is to reduce the item search time within the fingerprint database without affecting the accuracy rate. In this paper, a novel technique, based on topological information, for efficient fingerprint classification is described. The proposed system is composed of two independent modules: the former module, based on Fuzzy C-Means, extracts the best set of training images, the latter module, based on Fuzzy C-Means and Naive Bayes classifier, assigns a class to each processed fingerprint using only directional image information. The proposed approach does not require any image enhancement phase. Experimental trials, conducted on a subset of the free downloadable PolyU database, show a classification rate of 91% over a 100 images test database using only 12 training examples.
Integrating Vehicle Routing and Motion Planning

There has been much interest recently in problems that com-bine high-level task planning with low-level motion planning.In this paper, we present a problem of this kind that arises inmulti-vehicle mission planning. It tightly integrates task al-location and scheduling, who will do what when, with pathplanning, how each task will actually be performed. It ex-tends classical vehicle routing in that the cost of executing aset of high-level tasks can vary significantly in time and costaccording to the low-level paths selected. It extends classi-cal motion planning in that each path must minimize costwhile also respecting temporal constraints, including thoseimposed by the agent’s other tasks and the tasks assigned toother agents. Furthermore, the problem is a subtask withinan interactive system and therefore must operate within se-vere time constraints. We present an approach to the problembased on a combination of tabu search, linear programming,and heuristic search. We evaluate our planner on represen-tative problem instances and find that its performance meetsthe demanding requirements of our application. These resultsdemonstrate how integrating multiple diverse techniques cansuccessfully solve challenging real-world planning problemsthat are beyond the reach of any single method.
Predicting subcellular localization of proteins for Gram‐negative bacteria by support vector machines based on n‐peptide compositions

Gram‐negative bacteria have five major subcellular localization sites: the cytoplasm, the periplasm, the inner membrane, the outer membrane, and the extracellular space. The subcellular location of a protein can provide valuable information about its function. With the rapid increase of sequenced genomic data, the need for an automated and accurate tool to predict subcellular localization becomes increasingly important. We present an approach to predict subcellular localization for Gram‐negative bacteria. This method uses the support vector machines trained by multiple feature vectors based on n‐peptide compositions. For a standard data set comprising 1443 proteins, the overall prediction accuracy reaches 89%, which, to the best of our knowledge, is the highest prediction rate ever reported. Our prediction is 14% higher than that of the recently developed multimodular PSORT‐B. Because of its simplicity, this approach can be easily extended to other organisms and should be a useful tool for the high‐throughput and large‐scale analysis of proteomic and genomic data.
XTC: a practical topology control algorithm for ad-hoc networks

Summary form only given. The XTC ad-hoc network topology control algorithm introduced shows three main advantages over previously proposed algorithms. First, it is extremely simple and strictly local. Second, it does not assume the network graph to be a unit disk graph; XTC proves correct also on general weighted network graphs. Third, the algorithm does not require availability of node position information. Instead, XTC operates with a general notion of order over the neighbors' link qualities. In the special case of the network graph being a unit disk graph, the resulting topology proves to have bounded degree, to be a planar graph, and - on average-case graphs - to be a good spanner.
Increased Nitric Oxide and Attenuated Diastolic Blood Pressure Variability in African Americans with Mildly Impaired Renal Function

We investigated the relationship between renal function, blood pressure variability (BPV), and nitric oxide (NO) in a group of African Americans with normal or mildly impaired renal function. 24-hour ambulatory blood pressure monitoring was performed, NO measured, and glomerular filtration rate (GFR) calculated in 38 African Americans. Participants were categorized as having normal (GFR > 90 mL/min per 1.73 m2) or mildly impaired (GFR 60–89 mL/min per 1.73 m2) renal function. Diastolic BPV was significantly lower in the mildly impaired renal function group. Regression analyses revealed a significant positive association between GFR and diastolic BPV for the entire study group. Plasma NO levels were significantly higher in the mildly impaired renal function group and negatively correlated with diastolic BPV. In conclusion, diastolic BPV was reduced in African Americans with mildly impaired renal function, which may be the result of increased NO production. These results conflict with previous findings in diseased and nonblack populations and could provide rationale for studying BPV early in the disease state when BP-buffering mechanisms are still preserved.
Developing and Evaluating the S.A.F.E.R. Near Water Program: An Intervention to Enhance Beliefs Relevant to Supervision and Drowning Risk in Parents With Young Children in Swimming Lessons

DEVELOPING AND EVALUATING THE S.A. F.E. R. NEAR WATER PROGRAM: AN INTERVENTION TO ENHANCE BELIEFS RELEVANT TO SUPERVISION AND DROWNING RISK IN PARENTS WITH YOUNG CHILDREN IN SWIMMING LESSONS Megan C. Sandomierski Advisor: University of Guelph, 2017 Barbara A. Morrongiello The current study aimed to develop and evaluate the S.A. F.E. R. Near Water program, an evidence-based and theory-driven intervention targeting parent beliefs relevant to keeping children safe around water. Parents with children aged two through five years who were enrolled in lessons at both public and private swim organizations participated. Within each organization, parents were assigned to either an Intervention or Control Condition. All parents completed the same questionnaire measures at the beginning and end of their child’s swim lesson period. Parents in the Intervention Condition participated in the S.A. F.E. R. Near Water program, which comprised in-person educational seminars, informational handouts, and posters reinforcing key safety messages. Results revealed that S.A. F.E. R. Near Water successfully communicated most intended messages and was well received by parents. It significantly improved parental perceptions related to supervision, drowning risk, optimism bias, and water safety. These findings are encouraging for the use of a multifaceted, parentfocused, educational program alongside swim programming to promote closer adult supervision of children around water.
Novel frame selection methods for multi-reference motion estimation

This paper proposes two efficient frame selection methods to improve rate distortion performance and to reduce the computation complexity for frame selection. The proposed Reference Selection Pass (RSP) method can simplify early termination conditions by using the results of the previous coded blocks. The Improved Frame Selection (IFS) method controls the number of reference frames according to the accuracy of frame selection. The simulation results show the proposed methods can eliminate the overhead of early termination conditions with only 0.05 dB average Bjontegaard Delta (BD)-PSNR degradation.
Selective viral immunosuppression of the graft-versus-host reaction

Graft-vs.-host (GVH) reactivity of parental lymph node (LN) cells was assayed by measurements of 3H-thymidine incorporation in vivo in spleens of irradiated F1 recipients. Preincubation of parental LN cells with vesicular stomatitis virus (VSV) for 2 h at 37 degrees C followed by washing resulted in an 85-90% reduction in splenic radioactivity, as did injection of VSV on days 0-2 after recipients received untreated parental LN cells. In contrast, 3H-thymidine incorporation in the spleens or irradiated F1 hosts was not affected by VSV when F1 bone marrow cells were incubated with the virus. In addition, preincubation of F1 B cells with VSV still allowed these syngeneic B cells to be recruited into proliferation by mitomycin-treated parental LN cells. The inhibitory effect of VSV, thus, seems to be specific for T-cell proliferation. These observations suggest that viral immunosuppression might be capable of being developed into a useful strategy for selective deletion of lymphocytes capable of reacting against histocompatibility antigens and initiating GVH reactions.
A Novel Method for Extracting Information from Web Pages with Multiple Presentation Templates

Web information extraction is the key part of web data integration. With the need of e-commerce website and the development of web design, web pages with multiple presentation templates arise. The current web information extraction systems are usually based on single presentation template, so web pages with multiple presentation templates can’t be extracted efficiently. This paper focuses on the extraction problem about web pages with multiple presentation templates. Four different kinds of this problem have been considered, and a novel method based on path entropy, presentation regularity and ontology knowledge is presented. The experiment indicates that this method is very promising and it achieves excellent recall and precision.
Calculating scattering amplitudes efficiently

We review techniques for more efficient computation of perturbative scattering amplitudes in gauge theory, in particular tree and one- loop multi-parton amplitudes in QCD. We emphasize the advantages of (1) using color and helicity information to decompose amplitudes into smaller gauge-invariant pieces, and (2) exploiting the analytic properties of these pieces, namely their cuts and poles. Other useful tools include recursion relations, special gauges and supersymmetric rearrangements. 46 refs., 11 figs.
The Effects of Amino Acid Nutritional Deficiency on the Expression of Protein Metabolism-Related Genes in the Mammary Gland and Muscle Tissues of Lactating Mice

The mammary gland tissue exhibits a series of responses that are different from those of muscle and other peripheral tissues under amino acid deficiency. So, this present study was designed to investigate the effects of amino acid nutritional deficiency on the expression of protein metabolism-related genes in the mammary gland and muscle tissues of lactating mice. A total of 60 postpartum, lactating Kunming white mice were selected and randomly divided into 5 groups; each group contained 12 mice. Group A was the control group. The mice in group A were maintained on a normal diet after the initiation of lactation. Group B (starved) was given normal saline via intragastric administration. Group C (energy) was given glucose solution via intragastric administration. Groups D and E received a sodium caseinate solution via intragastric administration, which provided 0.5 g protein/d and 1.5 g protein/d, respectively. The results showed the following. 1) When the mice were exposed to nutritional stress caused by dietary amino acid deficiency, the β-casein mRNA expression level was increased in the mammary gland tissue. The increase in β-casein expression was the most significant in the energy-supplemented group, followed by the starved group (P P 14k and C2 (P P P < 0.05). 5) The phosphorylation level of p70S6K was elevated in the muscle tissues collected from the treatment groups. However, the magnitude of the increase was far smaller compared to that in the mammary gland tissues.
Temperature sensor placement including routing overhead and sampling inaccuracies

Dynamic thermal management techniques require a collection of on-chip thermal sensors that imply a significant area and power overhead. Finding the optimum number of temperature monitors and their location on the chip surface to optimize accuracy is an NP-hard problem. In this work we improve the modeling of the problem by including area, power and networking constraints along with the consideration of three inaccuracy terms: spatial errors, sampling rate errors and monitor-inherent errors. The problem is solved by the simulated annealing algorithm. We apply the algorithm to a test case employing three different types of monitors to highlight the importance of the different metrics. Finally we present a case study of the Alpha 21364 processor under two different constraint scenarios.
Laminin receptors in the retina: sequence analysis of the chick integrin alpha 6 subunit. Evidence for transcriptional and posttranslational regulation

The integrin alpha 6 beta 1 is a prominent laminin receptor used by many cell types. In the present work, we isolate clones and determine the primary sequence of the chick integrin alpha 6 subunit. We show that alpha 6 beta 1 is a prominent integrin expressed by cells in the developing chick retina. Between embryonic days 6 and 12, both retinal ganglion cells and other retinal neurons lose selected integrin functions, including the ability to attach and extend neurites on laminin. In retinal ganglion cells, we show that this is correlated with a dramatic decrease in alpha 6 mRNA and protein, suggesting that changes in gene expression account for the developmental regulation of the interactions of these neurons with laminin. In other retinal neurons the expression of alpha 6 mRNA and protein remains high while function is lost, suggesting that the function of the alpha 6 beta 1 heterodimer in these cells is regulated by posttranslational mechanisms.
Solid-state nuclear magnetic resonance study of sepiolite and partially dehydrated sepiolite

The assignment of the 29Si CP/MAS-NMR spectrum of naturally-occurring sepiolite clay was re-examined using Si COSY and 1H-29Si HETCOR pulse sequences. Each of the three main resonances at −92.1, −94.6 and −98.4 ppm has been attributed to one of the three pairs of equivalent Si nuclei in the basal plane, and the resonance at −85 ppm to Q2(Si-OH) Si nuclei. On the basis of the COSY experiment, the resonance at −92.1 ppm is unambiguously assigned to the intermediate, near-edge Si sites. The HETCOR experiment revealed that the resonance at −94.6 ppm cross-polarizes almost entirely from the Mg-OH protons, and therefore is assigned to the central Si position. The remaining resonance at −98.4 ppm correlates strongly to the protons of the structural water molecules and therefore is assigned to the edge Si sites. Nearly complete rehydration was achieved at room temperature by exposing sepiolite samples that had been partially dehydrated at 120°C to water vapor or to D2O vapor. The rehydration results support the 29Si NMR peak assignments that were made on the basis of the COSY and HETCOR experiments.The 29Si CP/MAS-NMR spectrum corresponding to the folded sepiolite structure in which approximately one half of the structural water has been removed by heating to 350°C is reported for the first time. The chemical shift values and relative intensities are significantly different compared to the resonances that are observed in the corresponding spectrum of the true sepiolite anhydride. These observations support the earlier claim that sepiolite heated to ∼350°C exists as a distinct phase to be differentiated from that of the completely dehydrated state.
RIPPS: Rogue Identifying Packet Payload Slicer Detecting Unauthorized Wireless Hosts Through Network Traffic Conditioning

Wireless network access has become an integral part of computing both at home and at the workplace. The convenience of wireless network access at work may be extremely beneficial to employees, but can be a burden to network security personnel. This burden is magnified by the threat of inexpensive wireless access points being installed in a network without the knowledge of network administrators. These devices, termed <it>Rogue Wireless Access Points</it>, may allow a malicious outsider to access valuable network resources, including confidential communication and other stored data. For this reason, wireless connectivity detection is an essential capability, but remains a difficult problem. We present a method of detecting wireless hosts using a local RTT metric and a novel packet payload slicing technique. The local RTT metric provides the means to identify physical transmission media while packet payload slicing conditions network traffic to enhance the accuracy of the detections. Most importantly, the packet payload slicing method is transparent to both clients and servers and does not require direct communication between the monitoring system and monitored hosts.
Loss of proliferative potential during terminal differentiation coincides with the decreased abundance of a subset of heterogeneous ribonuclear proteins

The decrease in abundance of a subset of highly conserved basic nuclear proteins is established to correlate with the loss of proliferative potential in association with the process of terminal differentiation in murine mesenchymal stem cells and human keratinocytes. These proteins, designated P2Ps for proliferation potential proteins, have apparent molecular masses of 30-40 kD, are associated with the 30-40S substructures of nuclear hnRNP complexes, and are recognized by antibodies made against core proteins of hnRNP particles. They also share an epitope in common with heat shock protein-90 (hsp90) and are recognized by two mAbs against hsp90. Two-dimensional electrophoretic Western blots furthermore show that P2Ps make up a subset of hnRNP proteins. Cells that possess these proteins express the potential to proliferate whether or not they are traversing the cell cycle. These include rapidly growing cells, reversibly growth-arrested cells, and nonterminally differentiated cells. In contrast, cells that have irreversibly lost their proliferative potential, such as terminally differentiated cells, show a marked reduction in the abundance of P2Ps as determined by immunodetection on Western blots. A correlation, therefore, exists between the presence of this subset of nuclear proteins and the proliferative potential in two cell types. These results raise the possibility that as a subset of hnRNP proteins, P2Ps may mediate posttranscriptional control of the processing of specific RNAs required for cell proliferation.